Document:

Subordinated Convertible Note and Warrant Purchase Agreement

 Exhibit 10.1 
 NIMBLEGEN SYSTEMS INC. 
 SUBORDINATED CONVERTIBLE NOTE AND WARRANT 
 PURCHASE AGREEMENT 
 MAY 21, 2004 

 Table of Contents 
  

					
	 	  	 	  	Page
	 1.
	  	AGREEMENT TO SELL AND PURCHASE	  	1
	     1.1
	  	Subject Securities	  	1
	     1.2
	  	Additional Subject Securities	  	2
			
	 2.
	  	CLOSINGS, DELIVERY AND PAYMENT	  	2
	     2.1
	  	Closings	  	2
	     2.2
	  	Delivery	  	3
	     2.3
	  	Use of Proceeds	  	3
	     2.4
	  	Penalty for Failure to Purchase Notes at Second Closing	  	3
			
	 3.
	  	REPRESENTATIONS AND WARRANTIES OF THE COMPANY	  	4
	     3.1
	  	Organization, Good Standing and Qualification	  	4
	     3.2
	  	Subsidiaries	  	4
	     3.3
	  	Capitalization; Voting Rights	  	4
	     3.4
	  	Authorization; Binding Obligations	  	5
	     3.5
	  	Liabilities	  	5
	     3.6
	  	Agreements; Action	  	6
	     3.7
	  	Agreements with or Obligations to Related Parties	  	6
	     3.8
	  	Title to Properties and Assets; Liens, Etc	  	7
	     3.9
	  	Patents and Trademarks	  	7
	     3.10
	  	Compliance with Other Instruments	  	8
	     3.11
	  	Litigation	  	8
	     3.12
	  	Tax Returns and Payments	  	8
	     3.13
	  	Employees	  	9
	     3.14
	  	Registration Rights	  	9
	     3.15
	  	Compliance with Laws; Permits	  	9
	     3.16
	  	Voting Agreements	  	9
	     3.17
	  	Offering Valid	  	10
	     3.18
	  	Full Disclosure	  	10
	     3.19
	  	Qualified Small Business	  	10
	     3.20
	  	Real Property Holding Corporation	  	10
	     3.21
	  	Minute Books	  	10
	     3.22
	  	Financial Statements	  	10
	     3.23
	  	Absence of Material Changes	  	11
	     3.24
	  	Insurance	  	11
			
	 4.
	  	REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS	  	11
	     4.1
	  	Requisite Power and Authority	  	11
	     4.2
	  	Conflicts	  	11
	     4.3
	  	Investment Representations	  	12
			
	 5.
	  	COVENANTS	  	13
	     5.1
	  	Negative Covenants	  	13

  

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	     5.2
	  	Approval of Transactions	  	14
	     5.3
	  	Amendment of Charter/Registration Rights	  	14
			
	 6.
	  	CONDITIONS TO CLOSINGS	  	14
	     6.1
	  	Conditions to Obligations of the Purchasers at the First Closing	  	14
	     6.2
	  	Conditions to Obligations of the Purchasers at the Second Closing	  	17
	     6.3
	  	Conditions to Obligations of the Company	  	18
			
	 7.
	  	MISCELLANEOUS	  	19
	     7.1
	  	Governing Law	  	19
	     7.2
	  	Survival	  	19
	     7.3
	  	Successors and Assigns	  	19
	     7.4
	  	Entire Agreement	  	19
	     7.5
	  	Severability	  	19
	     7.6
	  	Amendment/Waiver	  	19
	     7.7
	  	Delays or Omissions	  	20
	     7.8
	  	Notices	  	20
	     7.9
	  	Expenses	  	20
	     7.10
	  	Attorneys’ Fees	  	21
	     7.11
	  	Titles and Subtitles	  	21
	     7.12
	  	Counterparts; Facsimile Signatures	  	21
	     7.13
	  	Further Assurances	  	21
	     7.14
	  	Broker’s Fees	  	21
	     7.15
	  	Confidentiality	  	21
	     7.16
	  	Pronouns	  	22
	     7.17
	  	Dispute Resolution	  	22
	     7.18
	  	References to Dollars	  	22
	     7.19
	  	Execution and Closing of the Transactions	  	22
	     7.20
	  	Waiver of Preemptive Rights	  	22

 Exhibits 
  

			
	 Exhibit A
	  	Form of Subordinated Promissory Note
		
	 Exhibit B-1
	  	Form of Warrant-First Closing
		
	 Exhibit B-2
	  	Form of Warrant-Second Closing
		
	 Exhibit C
	  	Subject Securities Purchased at First Closing
		
	 Exhibit D
	  	Subject Securities Purchased at Second Closing
		
	 Exhibit E
	  	Third Amended and Restated Certificate of Incorporation, as amended
		
	 Exhibit F
	  	Capitalization Table
		
	 Exhibit G
	  	Form of Legal Opinion

 Schedules 
 Schedule of Exceptions 
  

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 NIMBLEGEN SYSTEMS INC. 
 SUBORDINATED CONVERTIBLE NOTE AND 
 WARRANT PURCHASE AGREEMENT 

This SUBORDINATED CONVERTIBLE NOTE AND WARRANT PURCHASE AGREEMENT (the “Agreement”) is made and entered into as of May 21, 2004, by and
among NIMBLEGEN SYSTEMS INC., a Delaware corporation (the “Company”), and those purchasers (individually, a “Purchaser” and collectively, the “Purchasers”) whose signatures appear on the signature page hereto.

 RECITALS 
 WHEREAS, the
Company has authorized the sale and issuance to the Purchasers of subordinated promissory notes in the form attached hereto as Exhibit A (individually, a “Note” and collectively, the “Notes”) in an aggregate principal
amount of up to $2,500,000 and stock purchase warrants in the forms attached hereto as Exhibits B-1 and B-2 (individually, a “Warrant” and collectively, the “Warrants”). The Notes and the Warrants are referred
to herein collectively as the “Subject Securities”; 
 WHEREAS, the Purchasers desire to purchase the Subject Securities on the
terms and conditions set forth herein; and 
 WHEREAS, the Company desires to issue and sell the Subject Securities to the Purchasers on the
terms and conditions set forth herein. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing recitals and the mutual promises, representations, warranties, and covenants hereinafter set forth and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 
  

	1.	AGREEMENT TO SELL AND PURCHASE. 

 1.1 Subject
Securities. Subject to the terms and conditions hereof, the Company hereby agrees to issue and sell to each Purchaser, severally and not jointly, and each Purchaser agrees to purchase from the Company, severally and not jointly: (a) at the
First Closing (as defined below), the number and amount of Subject Securities set forth opposite such Purchaser’s name on Exhibit C attached hereto at a purchase price set forth on Exhibit C; and (b) if, but only
if, the Company elects to cause the Second Closing (as defined below) to occur, then at the Second Closing, the number and amount of the Subject Securities set forth opposite such Purchaser’s name on Exhibit D attached hereto at a
purchase price set forth on Exhibit D. 
 1.2 Additional Subject Securities. The parties acknowledge and agree that:
(i) the Company is selling at the First Closing Notes in the aggregate principal amount of $833,333 and Warrants as set forth herein and if the Company elects to cause the Second Closing 

 
to occur, will sell Notes in an additional aggregate amount of $1,666,667 and Warrants as set forth herein, and (ii) the Company has offered or intends
to offer, on the same terms and conditions as set forth herein for the Notes and Warrants purchased at the First Closing and the Second Closing, Notes in the additional aggregate amount of up to $250,000, together with additional Warrants related
thereto. The parties further acknowledge and agree that if any of such additional Notes or Warrants are sold, the following will apply: 
  

	 	(a)	all of such additional Notes and Warrants will be deemed for all purposes hereof to be “Subject Securities”; 

  

	 	(b)	The additional Notes, if any, issued pursuant to this Section 1.2 shall be in the form attached hereto as Exhibit A, but shall be dated as of the actual date of the
purchase and sale of such additional Notes; 

  

	 	(c)	The additional Warrants, if any, issued pursuant to this Section 1.2 shall be substantially in the form attached hereto as Exhibit B-1, provided, however, that the
amount of $1,250,000 in clause (i) of the first paragraph shall be replaced with an amount equal to one half of the aggregate principal amount of the additional Notes purchased under this Section 1.2; and 

  

	 	(d)	The Purchasers of such additional Notes and Warrants, if not already parties to this Agreement, shall be required to execute and deliver a joinder hereto, and this Agreement shall
be deemed amended by the addition of an Exhibit C-1, reflecting the Purchasers, number, and amount of the additional Subject Securities being purchased in the Supplemental Closing (as defined below) and by the amendment of Exhibit D,
reflecting the Purchasers, number, and amount of the additional Subject Securities being purchased in the Second Closing. 

  

	2.	CLOSINGS, DELIVERY AND PAYMENT. 

 2.1 Closings. The closing of the sale and purchase of the Subject Securities under this Agreement to the Purchasers set forth on Exhibit C (the “First Closing”) shall take place at the
offices of the Company on May 21, 2004 at 9:00 a.m. Central time, or at such other time or place as the Company and the Purchasers listed on Exhibit C may mutually agree (such closing date is hereinafter referred to as the
“First Closing Date”). The closing of the sale and purchase of the Subject Securities described in Section 1.2 (the “Supplemental Closing”), if any, shall take place at the offices of the Company at such time and place as
the Company and the Purchasers of such Subject Securities may mutually agree, but in any event not later than thirty (30) days after the First Closing Date (the date of such Supplemental Closing is hereinafter referred to as the
“Supplemental Closing Date”). The closing of the sale and purchase of the Subject Securities under this Agreement to the Purchasers set forth on Exhibit D (the “Second Closing”) shall, if it occurs, take place at the
offices of the Company at 9:00 a.m. CDT on the fifteenth (15th) day after written notice provided by the
Company to the Purchasers, which notice may not be given later than August 31, 2004, or at such earlier time and/or other place as the Company and the Purchasers listed on Exhibit D may mutually agree (the date of such closing is
hereinafter referred to as the 

  

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“Second Closing Date”). If the Company does not provide the notice referenced in the previous sentence on or before August 31, 2004, then the
Second Closing will not occur. The First Closing, the Supplemental Closing, and the Second Closing may sometimes be referred to herein individually as a “Closing” and collectively, as the “Closings.” The First Closing Date, the
Supplemental Closing Date, and the Second Closing Date may sometimes be referred to herein individually as a “Closing Date” and collectively, as the “Closing Dates.” 
 2.2 Delivery. At each Closing, subject to the terms and conditions hereof, the Company will deliver to each Purchaser Notes and Warrants
representing the Subject Securities purchased by such Purchaser at such Closing against payment of the purchase price therefor by wire transfer to such account as designated by the Company to the Purchasers. 
 2.3 Use of Proceeds. The proceeds from the sale of the Subject Securities shall be used by the Company as working capital for general corporate
purposes in accordance with the Company’s business plan. 
 2.4 Penalty for Failure to Purchase Notes at Second Closing. In the
event that any Purchaser (including, for purposes hereof, a subsequent holder of a Note) fails to purchase the full principal amount of Notes as reflected on Exhibit D (a “Defaulting Purchaser”), in addition to any remedies the
Company may have pursuant to this Agreement or applicable law, the other Purchasers (including, for purposes hereof, any subsequent holders of the Notes) who have purchased the full principal amount of their Notes as reflected on
Exhibit D (the “Complying Purchasers”) shall have the option to purchase any or all of the outstanding Notes held by the Defaulting Purchaser for a purchase price equal to one percent (1%) of the outstanding principal on
such Notes. Within ten (10) days after the Second Closing, the Company shall notify the Complying Purchasers of the aggregate principal amount of outstanding Notes held by Defaulting Purchasers, if any. Each Complying Purchaser will have twenty
(20) days after the delivery of such notice (the “Exercise Period”) to notify the Company of such Purchaser’s election to purchase a portion of such outstanding Notes. Each Complying Purchaser will be entitled to purchase a
fraction of such Notes, the numerator of which shall be equal to the principal amount of outstanding Notes held by such Complying Purchaser, and the denominator of which shall be equal to the aggregate principal amount of outstanding Notes held by
all Complying Purchasers who have elected to purchase Notes held by a Defaulting Purchaser. The closing on such purchase shall take place within twenty (20) days after the expiration of the Exercise Period. 
  

	3.	REPRESENTATIONS AND WARRANTIES OF THE COMPANY. 

 Except as
set forth on a Schedule of Exceptions delivered by the Company to the Purchasers prior to the execution and delivery of this Agreement, the Company hereby represents and warrants to the Purchasers as of the date of this Agreement as follows:

 3.1 Organization, Good Standing and Qualification. The Company is a corporation duly organized, validly existing and in good standing
under the laws of the State of Delaware. The Third Amended and Restated Certificate of Incorporation, as amended by that certain Certificate of Amendment dated as of February 4, 2004 (the “Charter”), is attached hereto as
Exhibit E and a copy of the 

  

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Bylaws of the Company have been provided to the Purchasers. The Company has all requisite corporate power and authority (a) to own and operate its
properties and assets, (b) to execute and deliver this Agreement, (c) to issue and sell the Subject Securities, (d) to carry out the provisions of this Agreement, the Stock Agreements (as defined below) and the Charter and (e) to
carry on its business as presently conducted. The Company is duly qualified and is authorized to do business and is in good standing as a foreign corporation in all jurisdictions in which the nature of its activities and of its properties (both
owned and leased) makes such qualification necessary, except for those jurisdictions in which failure to do so would not have a material adverse effect on the Company or its business, assets, financial condition or operations. 
 3.2 Subsidiaries. The Company does not own or control any equity security or other interest of any other corporation, limited partnership or other
business entity. The Company is not a participant in any joint venture, partnership or similar arrangement. 
 3.3 Capitalization; Voting
Rights. 
  

	 	(a)	The authorized capital stock of the Company consists of: (1) 10,137,627 shares of Common Stock, par value $0.001 per share (the “Common Stock”), 1,543,283 shares of
which are issued and outstanding, and 1,015,017 shares of which have been authorized for issuance to officers, directors, employees, and consultants pursuant to the Company’s 2000 Stock Option and Restricted Stock Plan; (2) 1,230,001
shares of Series A Preferred Stock, par value $0.001 per share, all of which are issued and outstanding; (3) 2,080,000 shares of Series B Preferred Stock, par value $0.001 per share, all of which are issued and outstanding;
(4) 1,075,715 shares of Series C Preferred Stock, par value $0.001 per share, all of which are issued and outstanding; and (5) 1,976,190 shares of Series D Preferred Stock, par value $.001 per share, all of which are issued and
outstanding. The outstanding capital stock of the Company is held by such persons and in such classes and numbers of shares as are reflected in the capitalization table attached hereto as Exhibit F. 

  

	 	(b)	The rights, preferences, privileges and restrictions of the shares of the Company’s capital stock are as stated in the Charter. Upon amendment of the Charter as described in
Section 5.3 of this Agreement, the shares of preferred stock or Common Stock purchasable upon conversion of the Notes and the shares of Common Stock purchasable upon exercise of the Warrants (collectively, the “Additional Shares”)
will have been duly authorized and validly reserved for issuance. Except as may be granted pursuant to the Company’s Third Amended and Restated Stockholders Agreement (the “Stockholders Agreement”), and the Company’s Third
Amended and Restated Registration Rights Agreement (the “Registration Rights Agreement”) (the Stockholders Agreement and the Registration Rights Agreement being referred to herein collectively as the “Stock Agreements”), there
are no outstanding options, warrants, rights (including conversion or preemptive rights and rights of first refusal), proxy or shareholder agreements, or agreements of any kind for the purchase or acquisition from the Company of any of its
securities. 

  

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	 	(c)	When issued in compliance with the provisions of this Agreement and the Charter (subject to the amendment referenced in Section 5.3, below), the Subject Securities and the
Additional Shares will be validly issued, fully paid and non-assessable, except as provided by Section 180.0622(2)(b) of the Wisconsin Statutes and judicial interpretations thereof. 

 3.4 Authorization; Binding Obligations. All corporate action on the part of the Company, its officers, directors and stockholders necessary for
the authorization of this Agreement, the performance of all obligations of the Company hereunder at the Closings and the authorization, sale, issuance and delivery of the Subject Securities pursuant hereto has been taken or will be taken prior to
the applicable Closing. This Agreement, when executed and delivered, will be the valid and binding obligation of the Company enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization,
fraudulent conveyance, moratorium or other laws of general application affecting enforcement of creditors’ rights, and (b) general principles of equity that restrict the availability of equitable remedies. The sale of the Subject
Securities is not subject to any preemptive rights or rights of first refusal that have not been properly waived or complied with. 
 3.5
Liabilities. Except as set forth on the Financial Statements (as defined below), the Company has no material liabilities and, to its knowledge, knows of no material contingent liabilities, except current liabilities incurred in the ordinary
course of business and liabilities which would not, under generally accepted accounting principles, be required to be disclosed on a balance sheet of the Company. 
 3.6 Agreements; Action. 
  

	 	(a)	There are no agreements, understandings, instruments, contracts, judgments, orders, writs or decrees to which the Company is a party or to its knowledge by which it is bound which
may involve (1) obligations (contingent or otherwise) of, or payments to, the Company in excess of $25,000 (other than obligations of, or payments to, the Company arising from the purchase of supplies or sale of Company products entered into in
the ordinary course of business), or (2) the transfer or license of any patent, copyright, trade secret or other proprietary right to or from the Company (other than licenses arising from the purchase of “off the shelf” or other
standard products), or (3) provisions restricting the development, manufacture or distribution of the Company’s products or services, or (4) indemnification by the Company with respect to infringements of proprietary rights (other
than indemnification obligations arising from purchase or sale or license agreements entered into in the ordinary course of business). 

  

	 	(b)	 The Company has not (1) declared or paid any dividends, or authorized or made any distribution upon or with respect to any class or series of its capital
stock, (2) incurred any indebtedness for money borrowed or any other 

  

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liabilities (other than with respect to indebtedness and other obligations incurred in the ordinary course of business or disclosed in the Financial
Statements) individually in excess of $25,000 or, in the case of indebtedness and/or liabilities individually less than $25,000, in excess of $50,000 in the aggregate, (3) made any loans or advances to any person, other than ordinary advances
for travel expenses, or (4) sold, exchanged or otherwise disposed of any of its assets or rights, other than the sale of its inventory in the ordinary course of business. 

  

	 	(c)	For the purposes of this Section 3.6, all indebtedness, liabilities, agreements, understandings, instruments, contracts and proposed transactions involving the same person or
entity (including persons or entities the Company has reason to believe are affiliated therewith) shall be aggregated for the purpose of meeting the individual minimum dollar amounts of such subsections. 

 3.7 Agreements with or Obligations to Related Parties. The Company has no agreements with or obligations to any officers, directors, stockholders,
or employees of the Company other than (a) agreements explicitly contemplated hereby or agreements set forth in the Stock Agreements, (b) agreements between the Company and its officers, directors and employees with respect to the sale of
the Company’s Common Stock, (c) obligations for payment of salary for services rendered, (d) obligations for reimbursement for reasonable expenses incurred on behalf of the Company and advances for relocation expenses, (e) other
standard employee benefits made generally available to all employees and (f) the Employment Agreements described in the Schedule of Exceptions. None of the officers, directors or stockholders of the Company, or any members of their immediate
families, are indebted to the Company or have any direct or indirect ownership interest in any firm or corporation with which the Company is affiliated (other than the Company and its subsidiaries) or with which the Company has a business
relationship, or any firm or corporation which competes with the Company, except that officers, directors and/or stockholders of the Company may own stock in publicly traded companies which may compete with the Company. No officer, director or
stockholder, or any member of their immediate families, is, directly or indirectly, interested in any material contract with the Company (other than such contracts which relate to any such person’s ownership of capital stock or other securities
of the Company and the Employment Agreement described in the Schedule of Exceptions). The Company is not a guarantor or indemnitor of any indebtedness of any other person, firm or corporation. 
 3.8 Title to Properties and Assets; Liens, Etc. The Company has good and marketable title to its properties and assets and good title to its
leasehold estates, in each case subject to no mortgage, pledge, lien, lease, encumbrance or charge, other than (a) those resulting from taxes which have not yet become delinquent, (b) minor liens and encumbrances which do not materially
detract from the value of the property subject thereto or materially impair the operations of the Company, and (c) those that have otherwise arisen in the ordinary course of business. 
  

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 3.9 Patents and Trademarks. 
  

	 	(a)	The Company has entered into an Exclusive License Agreement with the Wisconsin Alumni Research Foundation dated September 27, 1999 and amended April 24, 2000 which grants
the Company an exclusive license for certain uses of United States patents (WARF internal reference numbers P98077US, P98077WO, P99318US, P00127US and P00271US). 

  

	 	(b)	The Company is not aware that any of its employees is obligated under any contract (including licenses, covenants or commitments of any nature) or other agreement, or subject to any
judgment, decree or order of any court or administrative agency, that would interfere with such employee’s duties to the Company. 

  

	 	(c)	Neither the execution or delivery of this Agreement nor the carrying on of the Company’s business by the employees of the Company, will, to the Company’s knowledge,
conflict with or result in a breach of the terms, conditions or provisions of, or constitute a default under, any contract, covenant or instrument under which any employee is now obligated. The Company does not believe it is or will be necessary to
utilize any inventions, trade secrets or proprietary information of any of its employees made prior to their employment by the Company, except for inventions, trade secrets or proprietary information that have been assigned to the Company and which
are disclosed in the Schedule of Exceptions hereto. 

  

	 	(d)	The Disclosure Schedule lists all rights in and to all patents and patent applications, and trademarks and trademark applications, and all copyright registrations, owned, used and
licensed by the Company. 

 3.10 Compliance with Other Instruments. The Company is not in violation or default of any
term of its Charter or Bylaws, or to the Company’s knowledge, of any provision of any mortgage, indenture, contract, agreement, instrument or contract to which it is a party or by which it is bound or of any judgment, decree, order, writ,
federal or state statute, rule or regulation applicable to the Company. The execution, delivery, and performance of and compliance with this Agreement, and the issuance and sale of the Subject Securities pursuant hereto and of the Additional Shares
(subject to the amendment referenced in Section 5.3, below) pursuant to the Charter, will not, with or without the passage of time or giving of notice, result in any such material violation, or be in conflict with or constitute a default under
any such term, or result in the creation of any mortgage, pledge, lien, encumbrance or charge upon any of the properties or assets of the Company or the suspension, revocation, impairment, forfeiture or nonrenewal of any permit, license,
authorization or approval applicable to the Company, its business or operations or any of its assets or properties. 
 3.11
Litigation. There is no action, suit, proceeding or investigation pending or to the Company’s knowledge currently threatened against the Company that questions the validity of this Agreement or the Stock Agreements, or the right of the
Company to enter into any of such agreements, or to consummate the transactions contemplated hereby or thereby, or which might result, either 

  

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individually or in the aggregate, in any material adverse change in the business, assets, liabilities, financial condition, operations or prospects of the
Company, financially or otherwise, or any change in the current equity ownership of the Company. The foregoing includes, without limitation, actions, suits, proceedings or investigations pending or threatened involving the prior employment of any of
the Company’s employees, their use in connection with the Company’s business of any information or techniques allegedly proprietary to any of their former employers, or their obligations under any agreements with prior employers. The
Company is not a party or subject to the provisions of any order, writ, injunction, judgment or decree of any court or government agency or instrumentality. There is no action, suit, proceeding or investigation by the Company currently pending or
which the Company intends to initiate. 
 3.12 Tax Returns and Payments. The Company has timely filed all tax returns and reports
(federal, state and local) required to be filed by it. These returns and reports are true and correct in all material respects. All taxes shown to be due and payable on such returns, any assessments imposed with respect thereto, and to the
Company’s knowledge all other taxes due and payable by the Company on or before the date hereof, have been paid or will be paid prior to the time they become delinquent. The Company has not received any notices of deficiency nor is the Company
aware of any pending audits. The Company has no knowledge of any liability of any tax to be imposed upon its properties or assets as of the date of this Agreement for which the Company has not adequately provided. 
 3.13 Employees. The Company has no collective bargaining agreements with any of its employees. There is no labor union organizing activity pending
or, to the Company’s knowledge, threatened with respect to the Company. No employee of the Company has been granted the right to continued employment by the Company or to any material compensation following termination of employment with the
Company. The Company is not aware that any officer or key employee intends to terminate his or her employment with the Company, nor does the Company have a present intention to terminate the employment of any officer or key employee. 
 3.14 Registration Rights. Except as required pursuant to the Registration Rights Agreement, the Company is not under any obligation, and has not
granted any rights to register any of the Company’s outstanding securities or any of its securities that may hereafter be issued. 
 3.15 Compliance with Laws; Permits. The Company is not in violation of any applicable statute, rule, regulation, order or restriction of any domestic or foreign government or any instrumentality or agency thereof in respect of the
conduct of its business or the ownership of its properties which violation would materially and adversely affect the business, assets, liabilities, financial condition, operations or prospects of the Company. Subject to the accuracy of the
Purchasers’ representations in Section 4 of this Agreement, no governmental orders, permissions, consents, approvals or authorizations are required to be obtained and no registrations or declarations are required to be filed in connection
with the execution and delivery of this Agreement and the issuance of the Subject Securities or the Additional Shares, except such as have been duly and validly obtained or filed, or with respect to any filings that must be made after the Closings,
as will be filed in a timely manner. The Company has all franchises, permits, licenses and any similar authority necessary for the conduct of its business as now being conducted by it, the lack of which could materially 

  

 8 

 
and adversely affect the business, assets, liabilities, financial condition, operations or prospects of the Company and the Company believes it can obtain,
without undue burden or expense, any similar authority for the conduct of its business. The Company is not in default in any material respect under any of such franchises, permits, licenses or similar authority. 
 3.16 Voting Agreements. Except for the Stockholders Agreement, to the Company’s knowledge, no stockholders have entered into any agreement or
arrangement with respect to the voting of the Company’s securities. 
 3.17 Offering Valid. If the representations and warranties
of the Purchasers contained in Section 4.3 hereof are true and complete, the offer, sale and issuance of the Subject Securities and the Additional Shares will be exempt from the registration requirements of the Securities Act of 1933, as
amended (the “Securities Act”), and will have been registered or qualified (or are exempt from registration and qualification) under the registration, permit or qualification requirements of all applicable state securities laws. Neither
the Company nor any agent on its behalf has solicited any offers to sell or has offered to sell all or any part of the Subject Securities to any person or persons so as to bring the sale of such Subject Securities by the Company within the
registration provisions of the Securities Act or any state securities laws. Based on the representations and warranties of the Purchasers thereof, all sales of securities by the Company prior to the Closing Date have been exempt from the
registration requirements of the Securities Act, and have been registered or qualified (or are exempt from registration and qualification) under the registration, permit or qualification requirements of all applicable state securities laws.

 3.18 Full Disclosure. None of this Agreement, the exhibits hereto or any other document delivered at the Closings by the Company to
the Purchasers or their attorneys or agents in connection herewith or therewith or with the transactions contemplated hereby or thereby, contain any untrue statement of a material fact or omit to state a material fact necessary in order to make the
statements contained herein or therein not misleading. The Company is not aware of any facts which are not disclosed in this Agreement or the exhibits hereto or in other documents delivered at the Closings to the Purchasers or their attorneys or
agents in connection herewith, including without limitation, the Schedule of Exceptions, and which (individually or in the aggregate) materially adversely affect, or could be reasonably likely to materially and adversely affect, the business,
assets, liabilities, financial condition, operations or prospects of the Company. 
 3.19 Qualified Small Business. The Company is a
“qualified small business” within the meaning of Section 1202(d) of the Internal Revenue Code of 1986, as amended (the “Code”), as of the date hereof. The Company meets the “active business requirement” of
Section 1202(e) of the Code, and it has made no “significant redemptions” within the meaning of Section 1202(c)(3)(B) of the Code. 
 3.20 Real Property Holding Corporation. The Company is not a real property holding corporation within the meaning of Section 897(c)(2) of the Code and any regulations thereunder. 
  

 9 

 3.21 Minute Books. The minute books of the Company made available to the Purchasers contain a
complete summary of all meetings of directors and stockholders since the time of incorporation. 
 3.22 Financial Statements. The
Company has delivered to the Purchasers the unaudited balance sheet of the Company as of February 29, 2004 (the “Balance Sheet Date”) and the related unaudited income statements, stockholders’ equity and cash flows for the year
then ended (collectively the “Financial Statements”). The Financial Statements (a) are in accordance with the books and records of the Company and (b) present fairly in all material respects the financial position and results of
operations of the Company as of the dates and for the periods indicated and, to the knowledge of the Company, are in accordance with generally accepted accounting principles consistently applied. 
 3.23 Absence of Material Changes. Except for the fact that the Company has not been profitable and continues to incur expenses in excess of
$600,000 per month, which has resulted in a liquidity concern for the Company, since the Balance Sheet Date, there has not been any material adverse change in the business, assets, liabilities, financial condition, operations or prospects of the
Company, or any change in the accounting methods or practices followed by the Company. 
 3.24 Insurance. The Company maintains valid
policies of workers’ compensation insurance in the statutorily required amounts and valid insurance policies on its business, assets, properties and personnel of the kinds and in the amounts of not less than is customarily obtained by
corporations of established reputation engaged in the same or similar business and similarly situated, including insurance against loss, damage, fire, theft, public liability and other risks. The Company has no claims outstanding under any insurance
policy and, to the knowledge of the Company, no circumstances are threatened which could give rise to any claims. 
  

	4.	REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS. 

 Each of
the Purchasers hereby severally (but not jointly) represents and warrants to the Company as follows: 
 4.1 Requisite Power and
Authority. Such Purchaser has all necessary power and authority under all applicable provisions of law to execute and deliver this Agreement and to carry out its provisions. All action on such Purchaser’s part required for the lawful
execution, delivery and performance of this Agreement has been or will be effectively taken prior to the applicable Closing. Upon such Purchaser’s execution and delivery thereof, this Agreement will be the valid and binding obligation of such
Purchaser, enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, fraudulent conveyance, moratorium or other laws of general application affecting enforcement of creditors’
rights, and (b) general principles of equity that restrict the availability of equitable remedies. 
 4.2 Conflicts. Neither the
execution or delivery of this Agreement nor compliance with the terms and provisions hereof, on the part of such Purchaser will cause such Purchaser to breach any statute, ordinance or regulation of any governmental authority or will conflict with
or result in a breach of any of the terms, conditions or provisions of any agreement or instrument to which such Purchaser is a party or by which such Purchaser may be bound, or constitute a default thereunder. 
  

 10 

 4.3 Investment Representations. Such Purchaser understands that neither the Subject Securities nor
the Additional Shares have been registered under the Securities Act. Such Purchaser also understands that the Subject Securities are being offered and sold pursuant to an exemption from registration contained in the Securities Act based in part upon
such Purchaser’s representations contained in this Agreement. Such Purchaser hereby represents, warrants and agrees as follows: 
 (a) Purchaser Bears Economic Risk. Such Purchaser has substantial experience in evaluating and investing in private placement transactions of securities in companies similar to the Company so that such Purchaser is capable of
evaluating the merits and risks of its investment in the Company and has the capacity to protect its own interests. Such Purchaser must bear the economic risk of this investment indefinitely unless the Subject Securities (or the Additional Shares)
are registered pursuant to the Securities Act, or an exemption from registration is available. Such Purchaser understands that the Company has no present intention of registering the Subject Securities, the Additional Shares or any shares of its
stock. Such Purchaser also understands that there is no assurance that any exemption from registration under the Securities Act will be available and that, even if available, such exemption may not allow such Purchaser to transfer all or any portion
of the Subject Securities or the Additional Shares under the circumstances, in the amounts or at the times such Purchaser might propose. 
 (b) Acquisition for Own Account. Such Purchaser is acquiring the Subject Securities and will be acquiring the Additional Shares for such Purchaser’s own account for investment only, and not with a view
towards their distribution. 
 (c) Purchaser Can Protect Its Interest. By reason of its business or financial
experience, such Purchaser has the capacity to protect its own interests in connection with the transactions contemplated in this Agreement. 
 (d) Accredited Investor. Such Purchaser is an accredited investor within the meaning of Regulation D under the Securities Act. 
 (e) Company Information. Such Purchaser has had an opportunity to discuss the Company’s business, management and financial
affairs with directors, officers and management of the Company and has had the opportunity to review the Company’s operations and facilities. Such Purchaser has also had the opportunity to ask questions of and receive answers from, the Company
and its management regarding the terms and conditions of this investment. 
 (f) Resales. Such Purchaser acknowledges
and agrees that the Subject Securities, and, if issued, the Additional Shares, must be held indefinitely unless they are subsequently registered under the Securities Act or an exemption from such registration is available. 
  

 11 

	5.	COVENANTS. 

 5.1 Negative Covenants. In order to
induce the Purchasers to execute this Agreement, the Company covenants and agrees that from the First Closing Date until the Notes are repaid in full or converted into stock of the Company, unless the Purchasers purchasing (or subsequently holding)
not less than fifty percent (50%) of the aggregate principal amount of the Notes (the “Requisite Purchasers”) shall otherwise consent in writing, the Company shall not: 
 (a) Restricted Payments. Make any Restricted Payment. “Restricted Payment” shall mean: (1) any dividend or other
distribution by the Company based upon the stock of the Company (except dividends payable solely in stock of the Company); (2) any purchase, redemption or other acquisition, direct or indirect, by the Company, of stock of the Company, whether
now or hereafter outstanding; (3) any other distribution by the Company in respect of stock of the Company, whether now or hereafter outstanding, either directly or indirectly, whether in cash or property or otherwise; and (4) any payment
of management or other fees by the Company to any Affiliate, either directly or indirectly, whether in cash or property or otherwise (except for payments for services rendered by employees, directors or consultants of the Company in the ordinary
course of business). 
 (b) Investments, Loans and Advances. Make or have outstanding any loans or advances to, or
investments in (through the acquisition of securities or stock or otherwise), any person or entity except: 
 (i) advances in
the ordinary course of business to suppliers in respect to the purchase of supplies or equipment; 
 (ii) by endorsement of
negotiable instruments for deposit or collection in the ordinary course of business; 
 (iii) investments in obligations of
the United States Government or certificates of deposit of banks; 
 (iv) travel advances to employees in the ordinary course
of business; or 
 (v) investments in money market funds containing only investments rated at least A-1 or the equivalent
thereof by Standard & Poor’s Rating Group and maturing within twelve (12) months of the date of acquisition thereof. 
 (c) Additional Indebtedness. Incur any additional indebtedness, other than amounts payable to providers of goods and services in the ordinary course of business. 
 (d) Preferential Treatment. Give any preferential treatment to any Purchaser with respect to the payment of principal or interest
on the Notes, which shall be repaid to all Purchasers pari passu, according to the outstanding principal and interest due to such Purchaser. 
  

 12 

 5.2 Approval of Transactions. The Company shall use its good faith commercially reasonable efforts
to obtain any consents, permits, or waivers necessary or appropriate for the consummation of the transactions contemplated by this Agreement. 
 5.3 Amendment of Charter/Registration Rights. Upon the occurrence of an event giving rise to a conversion of the Notes and/or an exercise of the Warrants, the Company shall take all actions necessary and appropriate to:
(a) amend the Charter to authorize the Additional Shares; (b) reserve the Additional Shares for issuance and issue the Additional Shares as required pursuant hereto and to the Notes and Warrants; and (c) execute and use its good faith
commercially reasonable efforts to cause the other parties thereto to execute an amendment and restatement of the Registration Rights Agreement so as to bring the Additional Shares within the definition of Registrable Securities, and to give all of
the holders thereof the same rights and preferences as are granted to the holders of Registrable Securities thereunder, pari passu. 
  

	6.	CONDITIONS TO CLOSINGS. 

 6.1 Conditions to Obligations
of the Purchasers at the First Closing. The obligation of the Purchasers to purchase the Subject Securities hereunder at the First Closing is subject to the satisfaction, at or prior to the First Closing Date, of the following conditions:

 (a) Representations and Warranties True; Performance of Obligations. The representations and warranties made by the
Company in Section 3 hereof shall be true and correct as of the First Closing Date and the Company shall have performed and complied with all obligations and conditions herein required to be performed or complied with by the Company on or prior
to the First Closing, and there shall be no ongoing Event of Default, as defined in the form of Note. 
 (b) Consents,
Permits and Waivers. The Company shall have obtained any and all consents, permits and waivers necessary or appropriate for consummation of the transactions contemplated by this Agreement (except for such as may be properly obtained subsequent
to the First Closing). 
 (c) Compliance Certificate. The Company shall have delivered to each Purchaser a Compliance
Certificate, executed by the President of the Company, dated the First Closing Date, to the effect that the conditions specified in subsections (a) and (b) of this Section 6.1 have been satisfied. 
 (d) Schedule of Exceptions. The Company shall have delivered to each Purchaser any necessary changes to the Schedule of Exceptions
as a result of facts and circumstances arising after the date of execution and delivery of this Agreement and prior to the First Closing, which changes shall be in form and substance satisfactory to the Requisite Purchasers. 
 (e) Proceedings and Documents. All corporate and other proceedings in connection with the transactions contemplated at the First
Closing hereby and all documents and instruments incident to such transactions shall be reasonably satisfactory in substance and form to each Purchaser and its counsel, and each Purchaser and its counsel shall have received all such counterpart
originals or certified or other copies of such documents as they may reasonably request. 
  

 13 

 (f) Lien Search Results. The Company shall have delivered the results of a UCC
lien search performed within fifteen (15) days prior to the First Closing, the results of which shall be satisfactory to the Requisite Purchasers. 
 (g) Legal Opinion. The Company shall have delivered an opinion of Company counsel in the form attached hereto as Exhibit G. 
 6.2 Conditions to Obligations of the Purchasers at the Supplemental Closing. The obligation of the Purchasers to purchase the Subject Securities hereunder at the Supplemental Closing is subject to the
satisfaction, at or prior to the Supplemental Closing Date, of the following conditions: 
 (a) Representations and
Warranties True; Performance of Obligations. The representations and warranties made by the Company in Section 3 hereof shall be true and correct as of the Supplemental Closing Date and the Company shall have performed and complied with all
obligations and conditions herein required to be performed or complied with by the Company on or prior to the Supplemental Closing, and there shall be no ongoing Event of Default, as defined in the form of Note. 
 (b) Consents, Permits and Waivers. The Company shall have obtained any and all consents, permits and waivers necessary or
appropriate for consummation of the transactions contemplated by this Agreement (except for such as may be properly obtained subsequent to the Supplemental Closing). 
 (c) Compliance Certificate. The Company shall have delivered to each Purchaser a Compliance Certificate, executed by the President
of the Company, dated the Supplemental Closing Date, to the effect that the conditions specified in subsections (a) and (b) of this Section 6.2 have been satisfied. 
 (d) Schedule of Exceptions. The Company shall have delivered to each Purchaser any necessary changes to the Schedule of Exceptions
as a result of facts and circumstances arising after the date of execution and delivery of this Agreement and prior to the Supplemental Closing, which changes shall be, in form and substance, satisfactory to the Requisite Purchasers. 
 (e) Proceedings and Documents. All corporate and other proceedings in connection with the transactions contemplated at the
Supplemental Closing hereby and all documents and instruments incident to such transactions shall be reasonably satisfactory in substance and form to each Purchaser and its counsel, and each Purchaser and its counsel shall have received all such
counterpart originals or certified or other copies of such documents as they may reasonably request. 
 (f) Lien Search
Results. The Company shall have delivered the results of a UCC lien search performed within fifteen (15) days prior to the Supplemental Closing, the results of which shall be satisfactory to the Requisite Purchasers. 
  

 14 

 (g) Legal Opinion. The Company shall have delivered an opinion of Company counsel
in the form attached hereto as Exhibit G. 
 6.3 Conditions to Obligations of the Purchasers at the Second Closing. The
obligation of the Purchasers to purchase the Subject Securities hereunder at the Second Closing is subject to the satisfaction, at or prior to the Second Closing Date, of the following conditions: 
 (a) Representations and Warranties True; Performance of Obligations. Subject to the proviso in Section 6.3(c), below, the
representations and warranties made by the Company in Section 3 hereof shall be true and correct as of the Second Closing Date and the Company shall have performed and complied with all obligations and conditions herein required to be performed
or complied with by the Company on or prior to the Second Closing, and there shall be no ongoing Event of Default, as defined in the form of Note. 
 (b) Consents, Permits and Waivers. The Company shall have obtained any and all consents, permits and waivers necessary or appropriate for consummation of the transactions contemplated by this Agreement (except
for such as may be properly obtained subsequent to the Second Closing). 
 (c) Compliance Certificate. The Company
shall have delivered to each Purchaser a Compliance Certificate, executed by the President of the Company, dated the Second Closing Date, to the effect that the conditions specified in subsections (a) and (b) of this Section 6.3 have
been satisfied; provided, however, that the Company will have the right to update the Schedule of Exceptions as of the Second Closing Date for changes in facts and circumstances between the First Closing Date and the Second Closing
Date and all representations and warranties of the Company as of the Second Closing Date shall be deemed amended and supplemented by information set forth in such revised Schedule of Exceptions. 
 (d) Schedule of Exceptions. The Company shall have delivered to each Purchaser any necessary changes to the Schedule of Exceptions
as a result of facts and circumstances arising after the date of the First Closing and prior to the Second Closing, subject to the proviso set forth in Section 6.3(c), above, which changes shall be in form and substance satisfactory to the
Requisite Purchasers. 
 (e) Proceedings and Documents. All corporate and other proceedings in connection with the
transactions contemplated at the Second Closing hereby and all documents and instruments incident to such transactions shall be reasonably satisfactory in substance and form to the Requisite Purchasers and their counsel, and each Purchaser and its
counsel shall have received all such counterpart originals or certified or other copies of such documents as they may reasonably request. 
 (f) Lien Search Results. The Company shall have delivered the results of a UCC lien search performed within fifteen (15) days prior to the Second Closing, the results of which shall be satisfactory to the
Requisite Purchasers. 
  

 15 

 (g) Legal Opinion. The Company shall have delivered an opinion of Company counsel
in the form attached hereto as Exhibit G. 
 6.4 Conditions to Obligations of the Company. The Company’s obligation to
issue and sell the Subject Securities at each Closing is subject to the satisfaction, at or prior to such Closing, of the conditions set forth below: 
 (a) Representations and Warranties True. The representations and warranties in Section 4 made by each Purchaser shall be true and correct in all material respects at the applicable Closing Date, with the
same force and effect as if they had been made on and as of said date. 
 (b) Performance of Obligations. Each
Purchaser shall have performed and complied with all obligations and conditions herein required to be performed or complied with by it on or before such Closing. 
 (c) Compliance Certificate. Each Purchaser shall have delivered to the Company a Compliance Certificate, dated the applicable
Closing Date, executed by a duly authorized officer of such Purchaser, to the effect that the conditions in subsections (a) and (b) of this Section 6.4 have been satisfied. 
 (d) Consents, Permits and Waivers. The Company shall have obtained any and all consents, permits and waivers necessary or
appropriate for consummation of the transactions contemplated by this Agreement (except for such as may be properly obtained subsequent to the applicable Closing). 
  

	7.	MISCELLANEOUS. 

 7.1 Governing Law. This Agreement
shall be construed in accordance with and governed in all respects by the laws of the State of Wisconsin, without giving effect to conflict of laws principles. 
 7.2 Survival. The representations, warranties, covenants and agreements made herein shall survive any investigation made by the Purchasers or the Company and the closings of the transactions contemplated
hereby. 
 7.3 Successors and Assigns. No party may assign its rights under this Agreement without the consent of the other parties
hereto. Subject to the foregoing and except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto.

 7.4 Entire Agreement. This Agreement, the exhibits hereto, and the other documents delivered pursuant hereto constitute the full
and entire understanding and agreement among the parties with regard to the subject matter hereof and thereof and no party shall be liable or bound to any other in any manner by any representations, warranties, covenants and agreements except as
specifically set forth herein and therein. 
  

 16 

 7.5 Severability. In case any provision of this Agreement shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 7.6 Amendment/Waiver. This Agreement may be amended or modified and any event of default or obligation of the Company may be waived, only in writing signed by the Company and the Requisite Purchasers, provided that any amendment or
waiver which has a direct, materially disproportionate adverse affect on one or more Purchasers as compared to the other Purchasers must also be consented to in writing by the adversely affected Purchaser(s). 
 7.7 Delays or Omissions. It is agreed that no delay or omission to exercise any right, power or remedy accruing to any party, upon any breach,
default or noncompliance by another party under this Agreement, shall impair any such right, power or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of or in any similar
breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent or approval of any kind or character on the Purchasers’ part of any breach, default or noncompliance under this Agreement, or any
waiver on such party’s part of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies under this Agreement, or otherwise afforded to any
party, shall be cumulative and not alternative. 
 7.8 Notices. All notices required or permitted hereunder shall be in writing and
shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed facsimile if sent during normal business hours of the recipient, if not, then on the next business day, (c) five
(5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written
verification of receipt. All communications to the Purchasers shall be sent to the addresses set forth below, or to such other address as shall be designated in writing, with a copy to Foley & Lardner LLP, 150 East Gilman Street, Madison,
Wisconsin 53703, Attention: Anne E. Ross. All communications to the Company shall be sent to the addresses set forth below, or to such other address as shall be designated in writing: 
  

							
	 IF TO COMPANY:
	  	NimbleGen Systems Inc.	  		  	
		  	One Science Court	  		  	
		  	Madison, Wisconsin 53711	  		  	
		  	Attn: President	  		  	
		  	Fax: (608) 218-7601	  		  	
				
	 with a copy to:
	  	Godfrey & Kahn, S.C.	  		  	
		  	780 North Water Street	  		  	
		  	Milwaukee, Wisconsin 53202	  		  	
		  	Attn: Kenneth C. Hunt	  		  	
		  	Fax: (414) 273-5198	  		  	

 7.9 Expenses. Each party shall pay all costs and expenses that it incurs with respect to
the negotiation, execution, delivery and performance of this Agreement; provided, however, that following each Closing, the Company shall reimburse the reasonable fees and expenses of one counsel for the Purchasers incurred in connection with the
negotiation, execution, delivery and performance of this Agreement. 
  

 17 

 7.10 Attorneys’ Fees. In the event that any suit or action is instituted to enforce any
provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect to this Agreement, including
without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 
 7.11 Titles and Subtitles. The titles of the sections and subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
 7.12 Counterparts; Facsimile Signatures. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all
of which together shall constitute one instrument. This Agreement may be executed by facsimile and each facsimile signature will have the same effect as an original signature. 
 7.13 Further Assurances. The Company agrees, and shall cause its officers, to execute any other documents or take any other actions reasonably
requested by the Purchasers to fulfill the transactions described in and contemplated by this Agreement. Each Purchaser agrees, and shall cause its officers, to execute any other documents or take any other actions reasonably requested for the
Company to fulfill the transactions described in and contemplated by this Agreement. 
 7.14 Broker’s Fees. Each party hereto
represents and warrants that no agent, broker, investment banker, person or firm acting on behalf of or under the authority of such party hereto is or will be entitled to any broker’s or finder’s fee or any other commission directly or
indirectly in connection with the transactions contemplated herein. Each party hereto further agrees to indemnify each other party for any claims, losses or expenses incurred by such other party as a result of the representation in this
Section 7.14 being untrue. 
 7.15 Confidentiality. Each party hereto agrees that, except with the prior written consent of the
other parties and except as required by law, it shall at all times keep confidential and not divulge, furnish or make accessible to anyone any confidential information, knowledge or data concerning or relating to the business or financial affairs of
the other parties to which such party has been or shall become privy by reason of this Agreement, discussions or negotiations relating to this Agreement, the performance of their obligations hereunder or the ownership of the Subject Securities
purchased hereunder (collectively, the “Confidential Information”). To the extent a party is subject to state or federal law requiring disclosure of public records, such party agrees to exercise its discretionary authority, to the fullest
extent permitted under such law, to maintain the confidentiality of the parties’ Confidential Information and to notify the other parties of, and give them an opportunity to object to, any request for disclosure of any Confidential Information
relating to or provided by such other parties. The provisions of this Section 7.15 shall be in addition to, and not in substitution for, the provisions of any separate nondisclosure agreement executed by the parties hereto. 
  

 18 

 7.16 Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer
to the masculine, feminine or neutral, singular or plural, as to the identity of the parties hereto may require. 
 7.17 Dispute
Resolution. The parties shall attempt to resolve any disputes, controversies or other claims arising out of or in connection with this Agreement through negotiation. To the extent that any disputes, controversies or claims cannot be resolved as
a result of such discussions, such unresolved disputes, controversies and claims shall be settled by arbitration in accordance with the UNCITRAL Arbitration Rules in effect on the date of this Agreement. The appointing authority shall be the
International Chamber of Commerce in Chicago, Illinois. The number of arbitrators shall be three (3). The place of arbitration shall be Chicago, Illinois, United States of America. The language to be used in the arbitration shall be English. In
connection with the arbitration, the Federal Rules of Evidence in effect in the United States of America will govern evidentiary questions and the procedural and substantive rules of the State of Wisconsin, United States of America will apply.
Judgment upon the award rendered may be entered in any court having jurisdiction. Application shall be made to such court for judicial acceptance of the award and an order of enforcement as the case may be. The parties acknowledge and agree that
this Agreement and all agreements, documents, instruments and certificates delivered in connection herewith and any award rendered pursuant hereto or thereto shall be governed by the 1958 United Nations Convention on the Recognition and Enforcement
of Foreign Arbitral Awards. In the event any conflict between the UNCITRAL Arbitration Rules and this clause, this clause shall govern. 
 7.18 References to Dollars. All references herein to “$” or “Dollars” shall be to United States Dollars. 
 7.19 Execution and Closing of the Transactions. It is anticipated that this Purchase Agreement may be executed, and the transactions contemplated by this Purchase Agreement may be closed and consummated, by the transmission of
documents, signature pages of documents and funds by mail, delivery service, fax or other electronic transmission. Each party hereto agrees that the faxed delivery of a counterpart signature page to the other parties or their representatives shall
constitute such party’s execution and delivery thereof. 
 7.20 Waiver of Preemptive Rights. Each Purchaser acknowledges and
agrees that by executing this Agreement, such Purchaser hereby waives its rights under the Stockholders Agreement and the Charter to consider purchasing such Purchaser’s pro rata share of the Subject Securities and affirmatively consents to the
transactions contemplated by this Purchase Agreement, including the purchase of the Subject Securities by those Purchasers who may not have preemptive rights with respect to the transactions contemplated herein. 
 [Remainder of this page intentionally left blank.] 
  

 19 

 IN WITNESS WHEREOF, the parties hereto have executed this SUBORDINATED CONVERTIBLE NOTE AND WARRANT
PURCHASE AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	 COMPANY:

	
	 NIMBLEGEN SYSTEMS INC.

		
	 By:
	 	 /s/ David Sneider

	 Print Name:  David Sneider

	 Title:
	 	Vice President
	
	 PURCHASERS:

	
	 780 PARTNERS

		
	 By:
	 	 /s/ Richard J. Bliss

	 Print Name:  Richard J. Bliss

	 Title:
	 	Managing Partner
	
	 Address for notice:
 780 North Water Street
 Milwaukee, Wisconsin 53202
 Facsimile: (414) 273-5198

	
	 /s/ Frederick R. Blattner

	Frederick R. Blattner
	
	 Address for notice:
 Genetics Building, B10
 445 Henry Mall
 Madison, Wisconsin 53705
 Facsimile:                                     
                                        
      

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

			
	BVP I AFFILIATES FUND LIMITED PARTNERSHIP
		
	 By:
	 	 Baird Venture Partners Management
 Company I, L.L.C.,
its general partner

  

			
	By:	 	 /s/ Peter K. Shagory

	Print Name:  Peter K. Shagory
	Title:	 	Principal

  

	
	 Address for notice:

	 227 W. Monroe, Suite 2200

	 Chicago, Illinois 60606

	 Facsimile: (312) 609-4994

  

			
	BAIRD VENTURE PARTNERS I LIMITED PARTNERSHIP
		
	By:	 	 Baird Venture Partners Management
 Company I, L.L.C.,
its general partner

		
	By:	 	 /s/ Peter K. Shagory

	Print Name:  Peter K. Shagory
	Title:	 	Principal

  

	
	 Address for notice:

	 227 W. Monroe, Suite 2200

	 Chicago, Illinois 60606

	 Facsimile: (312) 609-4994

  

			
	FHF PARTNERS
		
	By:	 	 /s/ Mitchell S. Fromstein

	Print Name:  Mitchell S. Fromstein
	Title:	 	Managing Partner

  

			
	 Address for notice:

	 1501 East Fox Lane

	 Milwaukee, Wisconsin 53217

	 Facsimile: (414) 332-9213

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

			
	
	 /s/ Roland Green

	 Roland Green

	
	 Address for notice:

	 506 Ozark Trail

	 Madison, Wisconsin 53705

	 Facsimile:                                     
                                        
      

	
	ICE NINE INVESTMENTS LLC
		
	 By:
	 	 /s/ Nicholas J. Seay

	 Print Name:  Nicholas J. Seay

	 Title:
	 	Manager
	
	Address for notice:
	Nicholas Seay, Quarles & Brady
	U.S. Bank Plaza
	Madison, Wisconsin 53701
	Facsimile: (608) 251-9166
	
	 /s/ Emile Nuwaysir

	 Emile Nuwaysir

	
	Address for notice:
	2022 Madison Street
	Madison, Wisconsin 53711
	Facsimile:                                     
                                        
      
	
	  
 Frank V. Sica

	
	Address for notice:
	888 Seventh Avenue
	New York, New York 10106
	Facsimile:                                     
                                        
      

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

			
	 SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER II, L.P.

		
	By:	 	Skyline Venture Management II LLC, its General Partner
		
	By:	 	 /s/ John G. Freund

	Print Name:  John G. Freund
	Title:	 	Managing Director
	
	Address for notice:
	125 University Avenue
	Palo Alto, California 94301
	Facsimile: (650) 329-1090
	
	SKYLINE VENTURE PARTNERS II, L.P.
		
	By:	 	Skyline Venture Management II LLC, its General Partner
		
	By:	 	 /s/ John G. Freund

	Print Name:  John G. Freund
	Title:	 	Managing Director
	
	Address for notice:
	125 University Avenue
	Palo Alto, California 94301
	Facsimile: (650) 329-1090
	
	 /s/ David Sneider

	David Sneider
	
	Address for notice:
	Suite 422
	301 S. Yellowstone Drive
	Madison, Wisconsin 53705
	Facsimile: (608) 218-7601

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

			
	STATE OF WISCONSIN INVESTMENT BOARD
		
	By:	 	 /s/ Monica A. Jaehnig

	Print Name:  Monica A. Jaehnig
	Title:	 	Portfolio Manager, Wisconsin Private Equity Portfolio
	
	Address for notice:
	Lake Terrace
	121 East Wilson Street
	Madison, Wisconsin 53702
	Facsimile: (608) 266-2436
	
	TACTICS II LLC
		
	By:	 	 /s/ Robert J. Palay

	Print Name:  Robert J. Palay
	Title:	 	Managing Member
	
	Address for notice:
	5 Revere Drive
	Northbrook, Illinois 60062
	Facsimile:                                     
                                        
      
	
	 /s/ Michael Treble

	Michael Treble
	
	Address for notice:
	2820 Osmundsen Road
	Fitchburg, Wisconsin 53711
	Facsimile:                                     
                                        
      

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

			
	 VENTURE INVESTORS EARLY STAGE
 FUND III
LIMITED PARTNERSHIP

		
	By:	 	 Venture Investors Management LLC,
 its General
Partner

		
	By:	 	 /s/ John Neis

	Print Name:  John Neis
	Title:	 	Member
	
	Address for notice:
	505 South Rosa Road Suite 100
	Madison, Wisconsin 53719
	Facsimile: (608) 441-2727
	
	WISCONSIN ALUMNI RESEARCH FOUNDATION
		
	By:	 	 /s/ Martin C. Bear

	Print Name:  Martin C. Bear
	Title:	 	Director of Investments
		
	By:	 	 /s/ Kenneth G. Lutz

	Print Name:  Kenneth G. Lutz
	Title:	 	Controller
	
	Address for notice:
	614 Walnut Street, 13th Floor
	Madison, Wisconsin 53705
	Facsimile: (608) 263-1064
	
	  

	Stanley D. Rose
	
	Address for notice:
	One Science Court
	Madison, Wisconsin 53711
	Facsimile: 608-218-7601

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

	
	  

	 Rodney Wallace

	
	 Address for notice:

	  

	  

	 Facsimile:                                     
                                        
      

	
	  

	 Steven Smith

	
	 Address for notice:

	  

	  

	 Facsimile:                                     
                                        
      

	
	  

	 Daniel Clutter

	
	 Address for notice:

	  

	  

	 Facsimile:                                     
                                        
      

 [Signature Page to Subordinated Convertible Note and Warrant Purchase Agreement]

 EXHIBIT A 
 FORM OF NOTE 
 THE SECURITIES OF NIMBLEGEN SYSTEMS INC. REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 AS AMENDED (THE “SECURITIES ACT”) OR THE SECURITIES LAWS OF ANY STATE. THE HOLDER HEREOF, BY ACCEPTING THESE SECURITIES, AGREES FOR THE BENEFIT OF NIMBLEGEN SYSTEMS INC. THAT SUCH SECURITIES MAY BE RESOLD, PLEDGED,
OR OTHERWISE TRANSFERRED ONLY (I) PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OR (II) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE
SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OF AMERICA. NIMBLEGEN SYSTEMS INC. MAY REQUIRE AN OPINION OF COUNSEL SATISFACTORY TO IT THAT ANY TRANSFER IS IN COMPLIANCE WITH FEDERAL AND STATE SECURITIES LAWS AS A CONDITION TO ANY TRANSFER OF
SUCH SECURITIES. 
 THE SHARES OF STOCK OF NIMBLEGEN SYSTEMS INC. WHICH MAY BE EXERCISED UPON CONVERSION HEREOF (THE “SHARES”) WILL BE SUBJECT TO
CERTAIN RESTRICTIONS REGARDING THE RIGHT TO TRANSFER THE SHARES, CERTAIN RESTRICTIONS ON THE VOTING OF THE SHARES, AND CERTAIN OTHER PROVISIONS, ALL AS SET FORTH IN A STOCKHOLDERS AGREEMENT, AMONG NIMBLEGEN SYSTEMS INC. AND CERTAIN OF ITS
STOCKHOLDERS, AS SUCH AGREEMENT MAY BE AMENDED AND/OR RESTATED FROM TIME TO TIME. A COPY OF SUCH AGREEMENT IS AVAILABLE FOR INSPECTION AT THE PRINCIPAL OFFICE OF NIMBLEGEN SYSTEMS INC. NO TRANSFER, SALE, ASSIGNMENT, PLEDGE, HYPOTHECATION OR OTHER
DISPOSITION OF THE SHARES MAY BE MADE EXCEPT IN ACCORDANCE WITH THE PROVISIONS OF SUCH STOCKHOLDERS AGREEMENT. THE HOLDER OF THIS NOTE BY ACCEPTANCE OF THIS NOTE, AGREES TO BE BOUND BY ALL OF THE PROVISIONS OF SUCH AMENDED AND RESTATED STOCKHOLDERS
AGREEMENT. 
 NIMBLEGEN SYSTEMS INC. 
 UNSECURED SUBORDINATED CONVERTIBLE PROMISSORY NOTE 
                 , 2004 

			
	$                            	  	Madison, Wisconsin

 NIMBLEGEN SYSTEMS INC., a Delaware corporation (the “Company”), for value received,
hereby promises to pay to
                                        ,
a                                      (the
“Holder”), its successors and permitted assigns, the principal sum of
                             Dollars
($            ), together with interest calculated as set forth below. 
 1. Interest. Interest shall accrue on the unpaid principal balance from the date of this Note until the date repaid or converted in the manner provided for below, computed on the basis of a 360-day year, at a rate per annum equal to
    %. [Note: The interest  

 
rate to be completed will be the prime interest rate as quoted in The Wall Street Journal on the date of issuance, plus 2%.]
Notwithstanding the foregoing, from and after an Event of Default, as defined below, interest shall accrue at the rate of 12% per annum. 
 2. Repayment. 
 2.1 Repayment Date. All unpaid principal and interest shall be due and payable in full on the earlier
of: a) demand for repayment made by the Requisite Purchasers, as defined in the Subordinated Convertible Note and Warrant Purchase Agreement dated May     , 2004 (the “Purchase Agreement”) pursuant to which this
Note was purchased; or b) on the date of consummation of a Change in Control of the Company, as defined below. The date on which the Note is repaid pursuant to this Section 2.1 is hereinafter referred to as the “Repayment Date”. This
Note and such other Notes as are purchased under the Purchase Agreement are referred to hereinafter collectively as the “Notes”. 
 2.2 Repayment Premium. In the event the Notes are repaid in connection with a Change in Control (as defined below) of the Company prior to the consummation of a Qualified Financing (as defined below), or if the Requisite Purchasers
demand repayment in full at any time on or after August 31, 2004, in addition to all unpaid principal and interest, the Company shall pay the holder of this Note a payment equal to 150% of the original principal amount of the Note, payable at
the same time as the outstanding principal and interest. 
 2.3 “Change in Control” Defined. For purposes hereof, a
“Change in Control” shall mean the occurrence of any one of the following events: 
 (a) the date of the acquisition
by an individual, entity or group (each, a “Person”), within the meaning of Section 13(d)(2) of the Securities Exchange Act of 1934 as amended (the “Exchange Act”), of beneficial ownership, within the meaning of Rule 13d-3
of the Exchange Act, of 50% or more of either (A) the then outstanding shares of common stock of the Company (the “Outstanding Company Common Stock”) or (B) the combined voting power of the then outstanding voting securities of
the Company entitled to vote generally in the election of directors (the “Outstanding Company Voting Securities”); provided, however, that for purposes of this subsection (a), the following acquisitions shall not
constitute a Change in Control: (x) any acquisition of stock directly from the Company as part of a Financing (as defined below) or (y) a Qualified IPO, as defined in the Charter (as defined in the Purchase Agreement) giving rise to
conversion rights hereunder; or 
 (b) the date of consummation of a reorganization, merger or consolidation or sale or other
disposition of all or substantially all of the assets of the Company for which approval of the stockholders of the Company is required (each, a “Business Combination”), in each case, unless, immediately following such Business Combination,
(i) all or substantially all of the individuals and entities who were the beneficial owners, respectively, of the Outstanding Company Common Stock and Outstanding Company Voting Securities immediately prior to such Business Combination
beneficially own, directly or indirectly, more than 50% of, respectively, the then outstanding shares of common stock and the combined voting power of the 

  

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then outstanding voting securities entitled to vote generally in the election of directors, as the case may be, of the corporation resulting from such
Business Combination in substantially the same proportions as their ownership immediately prior to such Business Combination of the Outstanding Company Common Stock and Outstanding Company Voting Securities, as the case may be, and (ii) at
least a majority of the members of the Board of Directors of the corporation resulting from such Business Combination were members of the Board of Directors of the Company at the time of the execution of the initial agreement, or of the action of
the Board of Directors of the Company, providing for such Business Combination; or 
 (c) the date of approval by the
stockholders of the Company of a complete liquidation or dissolution of the Company; or 
 (d) the consummation of a sale,
lease, license, or exchange of substantially all of the operating assets of the Company to a third party. 
 3. No Collateral. The
obligations represented by the Note shall be unsecured obligations of the Company. 
 4. Prepayment. This Note may not be prepaid at
any time, in whole or in part, without the prior written consent of the Requisite Purchasers. 
 5. Events of Default. The unpaid
principal balance of this Note, together with all accrued but unpaid interest thereon, shall, at the option of the Requisite Purchasers and without presentation, demand, protest or further notice of any kind, become immediately due and payable upon
the occurrence of an Event of Default. For purposes hereof, an “Event of Default” means the occurrence of any one of the following events: 
 (a) If the Company shall fail to pay when due any principal, interest or other amounts payable under this Note and such failure shall continue for a period of 30 days after written notice from the Holder of such
failure to the Company; or 
 (b) If the Company shall (i) become insolvent or take or fail to take any action which
constitutes its admission of inability to pay its debts as they mature; (ii) make an assignment for the benefit of creditors, file a petition in bankruptcy, petition or apply to any tribunal for the appointment of a custodian, receiver or any
trustee for it or a substantial part of its assets; (iii) commence any proceeding under any bankruptcy, reorganization, arrangement, readjustment of debt, dissolution or liquidation law or statute of any jurisdiction, whether now or hereafter
in effect; (iv) have filed against it any such petition or application in which an order for relief is entered or which petition, application or order for relief remains undismissed for a period of 90 days or more; or (v) indicate its
consent to, approval of or acquiescence in any such petition, application or proceeding or order for relief or the appointment of a custodian, receiver or trustee for a substantial part of its properties, or shall suffer any custodianship,
receivership or trusteeship to continue undischarged for a period of 90 days or more; or 
  

 3 

 (c) If any representation or warranty made by the Company in this Note, that certain
Warrant to Purchase Common Stock granted by the Company to the Holder of even date herewith (the “Warrant”), the Third Amended and Restated Stockholders Agreement of the Company dated as of March 4, 2003 (the “Stockholders
Agreement”), or the Purchase Agreement proves to have been untrue, incomplete or misleading in any material respect when made or when deemed to have been made; or 
 (d) If the Company fails to observe or perform any covenant or agreement set forth in this Note, the Warrant, the Stockholders Agreement
or the Purchase Agreement and such failure shall continue for a period of 45 days after written notice from the Requisite Purchasers of such failure to the Company; or 
 (e) If the Company shall default in the performance or observance of any obligation or condition (including, without limitation, any
payment default, whether by scheduled maturity, required prepayment, acceleration, demand or otherwise) with respect to any indebtedness for borrowed money in the aggregate principal amount of $25,000 or more or any other event shall occur or
condition exist, if the effect of such default, event or condition is to accelerate the maturity of any such indebtedness for borrowed money or to permit (without regard to any required notice or lapse of time) the holder or holders thereof, or any
trustee or agent for such holders, to accelerate the maturity of any such indebtedness for borrowed money, or any such indebtedness for borrowed money shall become or be declared to be due and payable prior to its stated maturity other than as a
result of a regularly scheduled payment. 
 6. Conversion Rights. This Note shall be subject to the conversion rights and procedures
set forth below. 
 6.1 Conversion Events. 
 (a) Voluntary Conversion. In the event the Company offers and sells shares of preferred stock of the Company after the date hereof
in a transaction (a “Financing”) that is not: (i) a Qualified Financing, as defined below; or (ii) a Qualified IPO, the Requisite Purchasers may elect to have all of the outstanding Notes converted into shares of the class and
series of preferred stock being offered and sold in such Financing (the “Conversion Shares”), on the price and terms described below. In the event the Requisite Purchasers do not so elect, each Holder will have the option of converting
some or all of such Holder’s Notes to Conversion Shares on the price and terms described below. 
 (b) Automatic
Conversion. In the event the Company: (i) offers and sells shares of preferred stock in a Financing in which the Company will receive aggregate proceeds of not less than $4 million (exclusive of proceeds realized on conversion of debt
and any amounts realized on sale of preferred stock to Affymetrix or any other strategic investor which has other significant business dealings with the Company) (a “Qualified Financing”); or (ii) consummates a Qualified IPO prior to
such date as it consummates a Qualified Financing (or such earlier date on which the Note has been voluntarily converted), then all of the outstanding principal due under the Note and, at the Company’s option, any or all accrued interest, shall
be converted into: (1) in the case of a Qualified Financing, Conversion Shares; or (2) in the case of a Qualified IPO, Common Stock of the Company, at the price and on the terms set forth below. 
  

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 6.2 Manner of Exercise. If the Holder shall desire to exercise such Holder’s
conversion right, such Holder must give notice to the Company of such exercise within 20 days following receipt of notice from the Company that the Company has effectuated or intends to effect a Financing. The number of shares of Preferred Stock to
be received by the Holder upon such conversion shall be determined in accordance with Section 6.3 below. 
 6.3 Number
of Shares Issuable Upon Conversion. 
 (a) In the event the Notes are converted in a Financing, the Holder shall be
entitled to receive that number of Conversion Shares equal to the aggregate amount of outstanding principal and interest to be converted, divided by the price being paid for each Conversion Share by other investors in the Financing, rounded down to
the nearest whole number. 
 (b) In the event the Notes are converted in a Qualified IPO, the Holder shall be entitled to
receive that number of shares of Common Stock equal to the aggregate amount of outstanding principal and interest to be converted, divided by the price paid for each share of Series D Preferred Stock issued by the Company pursuant to the Series D
Preferred Stock Purchase Agreement dated March 4, 2003, rounded down to the nearest whole number. To the extent the Series D Conversion Price as provided for in then effective Certificate of Incorporation (the “Certificate”) is
adjusted pursuant to the provisions of the Certificate, then the price per share used to determine the number of shares of Common Stock issuable on conversion of the Notes will be adjusted accordingly. 
 6.4 Conversion Procedure. Prior to conversion of this Note as set forth in this Section 6, the Holder of this Note shall
surrender this Note at the principal office of the Company. Upon such surrender, the Company shall promptly issue and deliver at such office to such Holder a certificate or certificates for the number and class of shares to which such Holder shall
be entitled in accordance with Section 6.3, above. Such conversion shall be deemed to have been made immediately prior to the close of business on the date of such surrender of this Note, and the person or persons entitled to receive the shares
issuable upon such conversion shall be treated for all purposes as the record holder or holders of such Conversion Shares on such date. At the time of such conversion, the Company shall pay any unpaid interest due under this Note, together with any
remaining principal the conversion of which would have resulted in the issuance of a fractional share. 
 6.5 Issuance of
Conversion Shares. The issuance of certificates for shares upon conversion of this Note will be made without charge to the Holder for any issuance tax or other governmental charge in respect thereof or other cost incurred by the Company in
connection with such conversion and the related issuance of shares. The Company will not close its books against the transfer of this Note or of shares issued or issuable upon conversion of this Note in any manner which interferes with the timely
conversion of this Note. 
  

 5 

 6.6 Rights of Conversion Shares. Any Conversion Shares issued in connection with
the conversion of the Note under this Section 6 will be the same class and series issued by the Company in the Financing in which the Note was converted, will be subject to the rights, preferences and limitations with respect to such class and
series as are set forth in the Certificate and will be subject to the provisions of, and will be entitled, on a pari passu basis, to all the benefits accruing to other holders of Preferred Stock under the Stockholders Agreement, as such agreement
may be amended from time to time and the Company’s Third Amended and Restated Registration Rights Agreement as such agreement may be amended from time to time (the “Registration Rights Agreement”). As a condition to the receipt of any
of the Preferred Shares, the Holder agrees to execute and deliver any amendments to the Stockholders Agreement and the Registration Rights Agreement which are approved and agreed to by the Requisite Purchasers and the same class and series of
Preferred Stock issued in the Financing. 
 6.7 Reservation of Preferred Shares. Prior to effectuating a Financing, the
Company shall reserve and keep available out of its authorized but unissued Preferred Shares, solely for the purpose of effecting the conversion of this Note, such number of its Preferred Shares as shall from time to time be sufficient to effect the
conversion of this Note. 
 6.8 Rounding. All calculations under this Note shall be made to the nearest cent, as the
case may be. 
 6.9 Protection of Conversion Rights. The Company shall not amend the Certificate or participate in any
reorganization, transfer of assets, consolidation, merger, dissolution, issuance or sale of securities or any other voluntary action, for the purpose of avoiding or seeking to avoid the observance or performance of any of the terms to be observed or
performed hereunder by the Company, but will at all times in good faith assist in the carrying out of all the provisions of this Note and will take all actions that may be necessary or appropriate in order to protect the rights of the Holder of this
Note to convert the principal sum against impairment. 
 7. Notices. Any notices required or permitted to be given under this Note
shall be given and received in accordance with the provisions of Section 7.8 of the Purchase Agreement. 
 8. Assignment. Subject
to the restrictions on transfer described in Section 10, below, the rights and obligations of the Company and the Holder shall be binding upon and benefit the successors, assigns and transferees of the parties. 
 9. Waiver and Amendment. No provision of this Note may be waived, amended or modified without the prior written consent of the Holder (or, to the
extent provided for herein or in the Purchase Agreement, the Requisite Purchasers) and the Company. 
 10. Transfer of this Note. This
Note and the rights granted hereunder may not be transferred or succeeded to by any person without prior written notice to the Company describing briefly the manner of transfer, together with a written opinion of Holder’s 
  

 6 

 
counsel, or other evidence, if reasonably satisfactory to the Company, to the effect that such offer, sale or other distribution may be effected without
registration or qualification under any federal or state law then in effect, including without limitation, the Securities Act of 1933, as amended (the “Act”). Upon receiving such written notice and reasonable satisfactory opinion or other
evidence, the Company, as promptly as practicable but no later than fifteen (15) days after receipt of the written notice, shall notify the Holder that such Holder may sell or otherwise dispose of this Note, all in accordance with the terms of
the notice delivered to the Company; provided, however, that this Note may not be transferred to a person deemed by the Board of Directors of the Company, in its reasonable judgment, to be a competitor or potential competitor of the Company. If a
determination has been made pursuant to this Section 10 that the opinion of counsel for the Holder or other evidence is not reasonably satisfactory to the Company, the Company shall so notify the Holder promptly with details thereof after such
determination has been made. this Note may, as to such federal laws, be offered, sold or otherwise disposed of in accordance with Rule 144 or 144A under the Act, provided that the Company shall have been furnished with such information as the
Company may reasonably request to provide a reasonable assurance that the provisions of Rule 144 or 144A have been satisfied and subject to the proviso above limiting transfers to competitors. Notwithstanding the foregoing, the Holder may transfer
the rights granted hereunder, without the consent of the Company, to (i) any general or limited partner, member, officer or other Affiliate of the Holder or (ii) any entity or organization of which the Holder is a general or limited
partner, member, officer or other Affiliate. Subject to compliance with the foregoing sentence, this Note and all rights hereunder shall be transferable, in whole or in part, at the principal office of the Company by the Holder in person or by its
duly authorized attorney, upon surrender of this Note properly endorsed. The last holder of this Note as registered on the books of the Company may be treated by the Company and all persons dealing with this Note as the absolute owner hereof for any
purposes and as the person entitled to exercise the rights represented by this Note or to transfer hereof on the books of the Company, any notice to the contrary notwithstanding, unless and until such holder seeks to transfer registered ownership of
this Note on the books of the Company and such transfer is effected. 
 11. Treatment of Note. To the extent permitted by generally
accepted accounting principles, the Company will treat, account and report this Note as debt and not equity for accounting purposes and with respect to any returns filed with federal, state or local tax authorities. 
 12. No Stockholder Rights. Nothing contained in this Note shall be construed as conferring upon the Holder or any other person any rights as a
stockholder of the Company, including without limitation, the right to vote or to consent or to receive notice as a stockholder in respect of meetings of stockholders of the Company for the election of directors of the Company or any other matters
or any rights whatsoever as a stockholder of the Company; and no dividends or interest shall be payable or accrued in respect of this Note or the interest represented hereby or the Preferred Shares obtainable hereunder until, and only to the extent
that, this Note shall have been converted in accordance with Section 6. 
 13. Purchase Agreement. This Note is issued pursuant
to the Purchase Agreement and is subject to the terms and conditions thereof. 
  

 7 

 14. Currency. All payments on or in respect of this Note, including principal and interest, shall
be made in such coin and currency of the United States of America as at the time of payment is legal tender for the payment of public and private debts by check mailed and addressed to the registered Holder hereof at the address shown in the
register maintained by the Company for such purpose, or, at the option of the Holder hereof, in such manner and at such other place in the United States of America as the Holder hereof shall have designated to the Company in writing. Whenever a
payment to be made hereunder shall be due on a day which is not a business day, such payment shall be made on the next succeeding business day and such extension of time shall be included in the computation of the payment of interest hereunder.

 15. Waivers. The Company hereby waives diligence, presentment, demand, protest and notice of every kind whatsoever. The failure of
the Holder hereof to exercise any of its rights hereunder in any particular instance shall not constitute a waiver of the same or of any other right in that or any subsequent instance. 
 16. Governing Law. This Note is a contract made under and governed by, and shall be construed and enforced in accordance with, the laws of the
State of Wisconsin, without regard to conflict of laws principles. 
 17. Subordination. The Holder, by the Holder’s acceptance
hereof, and any subsequent holder of this Note, by acceptance hereof, acknowledges that the Company has borrowed, and may, provided it has obtained the consent of the Requisite Purchasers as required pursuant to the Purchase Agreement, from time to
time after the date hereof borrow, money from banks or other financial institutions engaged in the lending of money and/or may, in furtherance of its business, guaranty the obligations of others to such banks of financial institutions and that such
banks or financial institutions may from time to time require that the indebtedness evidenced by this Note be subordinated to notes, guaranties and other obligations of the Company to such banks or financial institutions. Accordingly, the Holder and
any subsequent holder hereof agrees, upon the request of the Company, to execute such subordination agreements and other instruments or documents as the Company may hereinafter require in order to subordinate the indebtedness evidenced by this Note,
or any portion thereof, or the payment of interest or principal hereunder, to any existing obligation of the Company to any such bank or financial institution, or to any future obligation which the Company may incur in compliance with the terms of
the Purchase Agreement. 
  

			
	NIMBLEGEN SYSTEMS INC.
		
	By:	 	  

		 	(Title)

  

			
	 Accepted and agreed to the      day of
            , 2004.

			
	 [Name of Holder]

		
	 By:
	 	  

		 	(Title)

  

 8 

 EXHIBIT B-1 
 FORM OF WARRANT—FIRST CLOSING 
 THE SECURITIES OF NIMBLEGEN SYSTEMS INC. REPRESENTED HEREBY HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED (THE “SECURITIES ACT”) OR THE SECURITIES LAWS OF ANY STATE. THE HOLDER HEREOF, BY ACCEPTING THESE SECURITIES, AGREES FOR THE BENEFIT OF NIMBLEGEN SYSTEMS INC. THAT SUCH SECURITIES MAY
BE RESOLD, PLEDGED, OR OTHERWISE TRANSFERRED ONLY (I) PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OR (II) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH CASE IN ACCORDANCE WITH ANY
APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OF AMERICA. NIMBLEGEN SYSTEMS INC. MAY REQUIRE AN OPINION OF COUNSEL SATISFACTORY TO IT THAT ANY TRANSFER IS IN COMPLIANCE WITH FEDERAL AND STATE SECURITIES LAWS AS A CONDITION TO ANY
TRANSFER OF SUCH SECURITIES. 
 THE SHARES OF STOCK OF NIMBLEGEN SYSTEMS INC. WHICH MAY BE PURCHASED UPON EXERCISE HEREOF (THE “SHARES”) WILL BE
SUBJECT TO CERTAIN RESTRICTIONS REGARDING THE RIGHT TO TRANSFER THE SHARES, CERTAIN RESTRICTIONS ON THE VOTING OF THE SHARES, AND CERTAIN OTHER PROVISIONS, ALL AS SET FORTH IN A STOCKHOLDERS AGREEMENT, AMONG NIMBLEGEN SYSTEMS INC. AND CERTAIN OF ITS
STOCKHOLDERS, AS SUCH AGREEMENT MAY BE AMENDED AND/OR RESTATED FROM TIME TO TIME. A COPY OF SUCH AGREEMENT IS AVAILABLE FOR INSPECTION AT THE PRINCIPAL OFFICE OF NIMBLEGEN SYSTEMS INC. NO TRANSFER, SALE, ASSIGNMENT, PLEDGE, HYPOTHECATION OR OTHER
DISPOSITION OF THE SHARES MAY BE MADE EXCEPT IN ACCORDANCE WITH THE PROVISIONS OF SUCH STOCKHOLDERS AGREEMENT. THE HOLDER OF THIS NOTE BY ACCEPTANCE OF THIS NOTE, AGREES TO BE BOUND BY ALL OF THE PROVISIONS OF SUCH AMENDED AND RESTATED STOCKHOLDERS
AGREEMENT. 
 NIMBLEGEN SYSTEMS INC. 
 WARRANT TO PURCHASE COMMON STOCK 
 This Warrant certifies that, for value received,
                                        
                     (the “Holder”) is entitled to subscribe for and purchase up to that number of shares (the “Warrant
Shares”) of fully paid and nonassessable Common Stock of NimbleGen Systems Inc., a Delaware corporation (the “Company”) equaling the sum of (a)     % [Note: Percentage to be inserted will be the
Holder’s pro rata share of the aggregate amount of Notes purchased at the Closing in which the Warrant is being issued] of the quotient of (i) $1,250,000 divided by (ii) the most recent price per share at which the outstanding
Subordinated Convertible Notes of the Company (the “Notes”) issued pursuant to the Purchase Agreement, as defined below, were converted into Preferred or 

 
Common Stock of the Company; or, if the Notes were not converted prior to the Repayment Date as defined in the Notes, the price paid per share of
Series D Preferred Stock of the Company pursuant to the Series D Preferred Stock Purchase Agreement dated March 4, 2003 (as applicable, the “Per Share Price”), plus (b)     % [Note: Percentage
to be inserted will be the Holder’s pro rata share of the aggregate amount of Notes purchased at the Closing in which the Warrant is being issued] of the quotient of (i) [the amount drawn under the Notes in the Closing in which the
Warrant is being issued] divided by (ii) the Per Share Price, at the Warrant Price (as defined in Section 2 hereof), subject to the provisions and upon the terms and conditions hereinafter set forth. This Warrant is issued pursuant to
the terms of the Subordinated Convertible Note and Warrant Purchase Agreement dated as of May     , 2004 among the Company, the Holder and certain other parties (the “Purchase Agreement”). Unless otherwise
indicated below, all capitalized terms used in this Warrant but not defined herein shall have the meanings set forth in the Purchase Agreement. For purposes hereof, the number of shares of Common Stock purchasable upon the exercise hereof shall be
referred to herein individually as a “Warrant Share” and collectively as the “Warrant Shares.” 
 1. Term of
Warrant. 
 (a) The purchase right represented by this warrant (hereinafter the “Warrant”) is exercisable, in
whole or in part, at any time during the term (the “Term”) commencing immediately after the closing of a Financing in which Notes are converted, or upon receipt of a notice as provided for in Section 1(b) hereof and ending upon the
earlier of (i) 5:00 p.m., Milwaukee, Wisconsin time, on April 30, 2014, or (ii) the termination of this Warrant as provided in Section 1(b) hereof. 
 (b) In the event of the consummation of a Qualified IPO or a Change in Control, as defined below, (a “Termination Event”), this
Warrant shall terminate immediately prior to such Termination Event (the “Effective Date”) and become null and void; provided, however, that if this Warrant shall not have otherwise terminated or expired, the Company shall give the Holder
notice of the Effective Date as soon as practicable and in any event not less than 20 days prior to the Effective Date and the Holder shall have the right until 5:00 p.m., Milwaukee, Wisconsin time, on the day immediately prior to the Effective Date
to exercise its rights hereunder to the extent not previously exercised. 
 2. Warrant Price. The initial exercise price of this
Warrant is $0.01 per share, subject to adjustment from time to time pursuant to the provisions of Section 5 hereof (the “Warrant Price”). 
 3. Exercise. The purchase right represented by this Warrant may be exercised by the Holder during the Term, in whole or in part, by the surrender of this Warrant (with the notice of exercise form attached
hereto as Exhibit 1 duly executed) at the principal office of the Company and by the payment to the Company, by check, wire transfer, cancellation of indebtedness or other obligations of the Company to the Holder or a combination of the
foregoing types of consideration, of an amount equal to the then applicable Warrant Price per share multiplied by the number of Warrant Shares then being purchased. The Company agrees that the Warrant Shares so purchased shall be deemed to be issued
to the Holder as the record owner of such Warrant Shares as of the close of business on the 
  

 2 

 
date on which this Warrant shall have been surrendered and payment made for such Warrant Shares as aforesaid. In the event of any exercise of this Warrant,
certificates for the Warrant Shares of stock so purchased shall be delivered to the Holder within five business days thereafter and, unless this Warrant has been fully exercised or expired, a new Warrant representing the portion of the Warrant
Shares, if any, with respect to which this Warrant shall not then have been exercised, shall also be issued to the Holder within such five business day period. 
 4. Stock Fully Paid, Reservation of Shares. All Common Stock which may be issued upon the exercise of this Warrant will, upon issuance, be fully paid and nonassessable, except as provided in
Section 180.0622(2)(b) of the Wisconsin Statutes. During the period within which the rights represented by this Warrant may be exercised, the Company will at all times have authorized, and reserved for the purpose of the issuance upon exercise
of the purchase rights evidenced by this Warrant and the Common Stock issuable upon such exercise or conversion, a sufficient number of shares of its Common Stock to provide for the exercise of the rights represented by this Warrant. 
 5. Adjustments. The kind of securities purchasable upon the exercise of this Warrant, the Warrant Price and the number of Warrant Shares
purchasable upon exercise of this Warrant shall be subject to adjustment from time to time upon the occurrence of certain events as set forth in this Section 5. Upon each adjustment of the Warrant Price under Sections 5(b) or 5(c) hereof, the
aggregate number of Warrant Shares acquirable upon exercise of this Warrant shall be adjusted to the number of shares determined by multiplying the Warrant Price in effect immediately prior to such adjustment by the number of Warrant Shares
acquirable upon exercise of this Warrant immediately prior to such adjustment, and dividing the product hereof by the Warrant Price resulting from such adjustment. 
 (a) Waiver of Adjustment to Warrant Price. Notwithstanding anything herein to the contrary, the operation of, and any adjustment of the Warrant Price or the number of Warrant Shares pursuant to, this
Section 5 may be waived by the Holder. Any waiver pursuant to this Section 5(a) shall bind all future holders of this Warrant. 
 (b) Adjustment for Subdivisions, Combinations or Consolidations of Common Stock. If the Company subdivides or combines its outstanding shares of Common Stock into a larger or smaller number of shares of Common Stock, the Warrant
Shares for which this Warrant may be exercised shall be increased or reduced, as of the record date for such subdivision or combination, in the same proportion as the increase or decrease in the outstanding shares of Common Stock, and the Warrant
Price shall remain the same so that the aggregate amount payable for the purchase of all Warrant Shares issuable hereunder immediately after the record date for such recapitalization shall equal the aggregate amount so payable immediately before
such record date. Any adjustment under this Section 5(b) shall become effective at the close of business on the date the subdivision or combination becomes effective. 
 (c) Adjustment for Certain Dividends and Distributions. If the Company declares a dividend on shares of Common Stock, or makes a distribution to
holders of shares of Common Stock, and such dividend or distribution is payable or made in shares of Common Stock or securities convertible into or exchangeable for shares of Common Stock, or rights to purchase shares of Common Stock or securities
convertible into or exchangeable for shares of Common Stock, the Warrant Shares for which this Warrant may be 

  

 3 

 
exercised shall be increased, as of the record date for determining which holders of shares of Common Shares shall be entitled to receive such dividend or
distribution, in proportion to the increase in the number of outstanding shares of Common Stock (and shares of Common Stock issuable upon conversion of all such securities convertible into shares of Common Stock) as a result of such dividend or
distribution, and the Warrant Price shall remain the same so that the aggregate amount payable for the purchase of all the Warrant Shares issuable hereunder immediately after the record date for such dividend or distribution shall equal the
aggregate amount so payable immediately before such record date. 
 (d) Adjustments for Dividends and Distributions other than Common
Stock. In the event the Company at any time or from time to time after the date of this Warrant shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Company other than shares of Common Stock (other than as otherwise adjusted in this Section 5), then and in each such event provision shall be made so that the Holder shall receive upon exercise hereof in addition
to the number of shares of Common Stock receivable thereupon, the amount of securities of the Company that the Holder would have received had this Warrant been exercised on the date of such event and had thereafter, during the period from the date
of such event to and including the date of exercise of this Warrant, retained such securities receivable by the Holder as aforesaid during such period giving application to all adjustments called for during such period (subject to all other
adjustments called for during such period under this Section 5), under this Section 5(d) with respect to the rights of the Holder. 
 (e) Adjustment for Reclassification, Exchange, or Substitution. In the event that at any time or from time to time after the date of this Warrant, the Common Stock issuable upon the exercise of this Warrant shall be changed into the
same or a different number of shares of any class or classes of stock, whether by capital reorganization, reclassification, or otherwise (other than an event provided for in Section 5(b) through Section 5(d)), above, the Warrant Price and
the number of Warrant Shares then in effect shall, concurrently with the effectiveness of such reorganization or reclassification, be proportionately adjusted such that the Warrant shall be exercisable for, in lieu of the number of shares of Common
Stock which the holder would otherwise have been entitled to receive, a number of shares of such other class or classes of stock equivalent to the number of shares of Common Stock that would have been subject to receipt by the Holder upon exercise
of this Warrant immediately before that change. 
 (f) Adjustments to Conversion Price. To the extent the Conversion Price as provided
in the Certificate with respect to: 
 (i) the series or class of Preferred Stock issued by the Company in the Next Preferred Stock Offering;
or 
 (ii) if the Notes were not converted prior to the Repayment Date as defined in the Notes, the Series D Preferred Stock,

 is adjusted pursuant to the provisions of the Certificate, then the Per Share Price used to determine the number of Warrant Shares shall be adjusted in
the same manner. 
  

 4 

 (g) Adjustment of Number of Outstanding Warrant Shares. In connection with any event which would
have the effect of increasing the number of Warrant Shares which would be issuable upon exercise of this Warrant, the Company shall issue to each holder of shares of Common Stock previously obtained upon exercise of this Warrant, the number of
shares of Common Stock which, when added to the number of shares of Common Stock previously obtained by such Holder upon exercise of this Warrant would equal the product of (i) the number of such shares of Common Stock previously obtained by
such holder upon exercise of this Warrant multiplied by (ii) the quotient of (A) the number of shares of Common Stock which would have been obtainable upon exercise of this Warrant after giving effect to such adjustment, divided by
(B) the number of shares of Common Stock which would have been obtainable upon exercise of this Warrant prior to giving effect to such adjustment. 
 (h) Closing of Books. The Company shall at no time close its transfer books against the transfer of any shares of Common Stock issued or issuable upon the exercise of this Warrant in any manner which interferes
with the timely conversion of such Warrant. 
 (i) Intent of Adjustment. If, pursuant to the provisions of this Section 5, an
event would cause an adjustment to be made to the Warrant Shares or the Warrant Price under more than one subsection of this Section 5, such event shall adjust the Warrant Shares and the Warrant Price only once and such subsections will not be
read so as to cause duplicate adjustments to the Warrant Shares or the Warrant Price, as the case may be, as a result of such event. 
 6.
Notice of Adjustments. Whenever the Warrant Price or Warrant Shares shall be adjusted pursuant to Section 5 hereof, the Company shall prepare a certificate signed by its Chief Financial Officer setting forth, in reasonable detail, the
event requiring the adjustment, the amount of the adjustment, the method by which such adjustment was calculated, the Warrant Price and number of Warrant Shares purchasable upon exercise hereof after giving effect to such adjustment and the number
of shares then purchasable upon exercise of this Warrant, and shall cause copies of such certificate to be mailed (by first class mail, postage prepaid) to the Holder at the address of the Holder on the signature page to the Purchase Agreement.

 7. Fractional Shares. No fractional shares of Common Stock will be issued in connection with any exercise or conversion hereunder,
but in lieu of such fractional shares the Company shall make a cash payment therefor upon the basis of the Warrant Price then in effect. 
 8. Rights of Shares of Common Stock. The shares of Common Stock issued in connection with the exercise of the Warrant will be subject to the rights, preferences and limitations with respect to such class and series as are set forth
in the Certificate and will be subject to the provisions of the Stockholders Agreement, as such agreement may be amended from time to time and the Company’s Third Amended and Restated Registration Rights Agreement or such agreement may be
amended from time to time (the “Registration Rights Agreement”). As a condition to the receipt of any of the shares of Common Stock upon the exercise hereof, the Holder agrees to execute and deliver any counterpart signature pages or
amendments to the Stockholders Agreement and the Registration Rights Agreement which are approved and agreed to by the other stockholders of the Company. 
  

 5 

 9. Securities Law Compliance. The Holder, by acceptance hereof, agrees that this Warrant and the
Warrant Shares to be issued upon exercise or conversion hereof are being acquired for investment pursuant to the provisions of the Purchase Agreement, including without limitation, the representations and warranties set forth in Section 4,
thereof. 
 10. Transfer of Warrant. This Warrant and the rights granted hereunder may not be transferred or succeeded to by any
person without prior written notice to the Company describing briefly the manner of transfer, together with a written opinion of Holder’s counsel, or other evidence, if reasonably satisfactory to the Company, to the effect that such offer, sale
or other distribution may be effected without registration or qualification under any federal or state law then in effect, including without limitation, the Securities Act of 1933, as amended (the “Act”). Upon receiving such written notice
and reasonable satisfactory opinion or other evidence, the Company, as promptly as practicable but no later than fifteen (15) days after receipt of the written notice, shall notify the Holder that such Holder may sell or otherwise dispose of
this Warrant, all in accordance with the terms of the notice delivered to the Company; provided, however, that this Warrant may not be transferred to a person deemed by the Board of Directors of the Company, in its reasonable judgment, to be a
competitor or potential competitor of the Company. If a determination has been made pursuant to this Section 10 that the opinion of counsel for the Holder or other evidence is not reasonably satisfactory to the Company, the Company shall so
notify the Holder promptly with details thereof after such determination has been made. Notwithstanding the foregoing, this Warrant may, as to such federal laws, be offered, sold or otherwise disposed of in accordance with Rule 144 or 144A under the
Act, provided that the Company shall have been furnished with such information as the Company may reasonably request to provide a reasonable assurance that the provisions of Rule 144 or 144A have been satisfied and subject to the proviso above
limiting transfers to competitors. Notwithstanding the foregoing, the Holder may transfer the rights granted hereunder, without the consent of the Company, to (i) any general or limited partner, member, officer or other Affiliate of the Holder
or (ii) any entity or organization of which the Holder is a general or limited partner, member, officer or other Affiliate. Subject to compliance with the foregoing sentence, this Warrant and all rights hereunder shall be transferable, in whole
or in part, at the principal office of the Company by the Holder in person or by its duly authorized attorney, upon surrender of this Warrant properly endorsed. The last holder of this Warrant as registered on the books of the Company may be treated
by the Company and all persons dealing with this Warrant as the absolute owner hereof for any purposes and as the person entitled to exercise the rights represented by this Warrant or to transfer hereof on the books of the Company, any notice to the
contrary notwithstanding, unless and until such holder seeks to transfer registered ownership of this Warrant on the books of the Company and such transfer is effected. 
 11. Definitions. The following terms are used and not otherwise defined herein: 
 (a)
Affiliate. The term “Affiliate” shall mean, as to any Person, any other Person (i) that directly or indirectly controls, is controlled by, or is under direct or indirect common control with, such Person, (ii) that directly
or indirectly owns 5% or more of the Voting Power of such Person, (iii) 5% or more of the Voting Power of which is directly or indirectly owned by such Person, or (iv) that has the power directly or indirectly to direct or cause the
direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or otherwise. 
  

 6 

 (b) Certificate. The term “Certificate” shall mean the Company’s Third Amended and
Restated Certificate of Incorporation, as amended by that certain Certificate of Amendment dated as of February 4, 2004 and as may be amended or restated from time to time. 
 (c) Change in Control. The term “Change in Control” shall have the same meaning as is ascribed to such term in the Notes. 
 (d) Common Stock. The term “Common Stock” shall mean the $.001 par value common stock of the Company. 
 (e) Person. The term “Person” shall mean any individual, corporation, limited liability company, partnership, joint venture,
association, joint stock company, trust, unincorporated organization, governmental authority or any other form of entity. 
 (f) Qualified
IPO. The term “Qualified IPO” shall have the meaning set forth in the Certificate. 
 (g) Voting Power. The term
“Voting Power” shall mean, with respect to any Person, the power to vote for or designate members of the board of directors, the manager or a similar person or group, whether exercised by virtue of the record ownership of securities, under
a close corporation or similar agreement or under an irrevocable proxy. 
 12. Miscellaneous. 
 (a) No Rights as Stockholder. Except as may be set forth in other instruments or agreements to which the Holder is a party, the Holder shall not be
entitled to vote or receive dividends or be deemed the holder of Common Stock or any other securities of the Company which may at any time be issuable on the exercise or conversion hereof for any purpose, nor shall anything contained herein be
construed to confer upon the Holder, as such, any of the rights of a stockholder of the Company or any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold consent to
any corporate action (whether upon any recapitalization, issuance of stock, reclassification of stock, change of par value or change of stock to no par value, consolidation, merger, conveyance or otherwise) or to receive notice of meetings, or to
receive dividends or subscription rights or otherwise until the Warrant shall have been exercised or converted and the shares purchasable upon the exercise or conversion hereof shall have become deliverable, as provided herein. 
 (b) Replacement. On receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and,
in the case of loss, theft or destruction, on delivery of an indemnity agreement or bond reasonably satisfactory in form and amount to the Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company, at its
expense, will execute and deliver, in lieu of this Warrant, a new Warrant of like tenor. 
 (c) No Impairment. The Company will not,
by amendment of its Certificate or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms to be observed or performed hereunder by the Company, but will at all times in good faith assist in the carrying out of all the provisions in the Warrant (including, but not limited to, Section 5 hereof). 
  

 7 

 (d) Amendment, Modification or Restatement. The parties may, by mutual agreement, amend, modify or
restate any provision or the entirety of this Warrant, provided that each such amendment, modification or restatement shall be in writing and shall be executed and delivered by each party. 
 (e) Severability. If any provision of this Warrant is held to be invalid, void or unenforceable for any reason, the remaining provisions shall
nevertheless continue in full force and effect, provided that nothing in this Section 12(e) shall be construed to limit or waive the breach of any representation with respect to enforceability of this Warrant. 
 (f) Third Party Beneficiaries. The obligations of each party under this Warrant shall inure solely to the benefit of the other parties, and no
other Person shall have any legal or equitable right, remedy, or claim under or with respect to this Warrant. 
 (g) Notice. Any
notices required or permitted to be given under this Warrant shall be given and received in accordance with the provisions of Section 7.8 of the Purchase Agreement. 
 (h) Assignment. Subject to the restrictions on transfer described in Section 10, above, the rights and obligations of the Company and the Holder shall be binding upon and benefit the successors, assigns
and transferees of the parties. 
 (i) Further Assurances. Each party hereto agrees to execute and deliver such further documents and
instruments and to do such further acts and things as may be necessary or desirable to carry out the intent and purposes of this Warrant. 
 (j) Governing Law. This Warrant shall be governed by and construed in accordance with the laws of the State of Wisconsin without regard to conflicts of law principles thereunder. 
  

 8 

 IN WITNESS WHEREOF, this Warrant is executed as of this      day of
                        , 2004. 
  

			
	NIMBLEGEN SYSTEMS INC.
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  

			
	 Accepted and agreed to the      day of
                        , 2004.

	
	 [Name of Holder]

			
	  
 By:
	 	  

		 	(Title)

  

 9 

 EXHIBIT 1 
 NOTICE OF EXERCISE 
 TO: NIMBLEGEN SYSTEMS INC. 
 1. The undersigned hereby elects to purchase shares of Common Stock of NIMBLEGEN SYSTEMS INC. pursuant to the terms of the attached Warrant, and tenders
herewith payment of the purchase price of such shares in full. 
 2. Please issue a certificate or certificates representing said shares of
Common Stock in the name of the undersigned or in such other name as is specified below: 
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Name) 
                                       
                                        
                                        
                                        
                                        
                                        
                    
                                       
                                        
                                        
                                        
                                        
                                        
                    
 (Address) 

3. The undersigned represents that the aforesaid shares of Common Stock are being acquired for the account of the undersigned for investment and not
with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares. 
  

	
	  

	Signature

  

 10 

 EXHIBIT B-2 
 FORM OF WARRANT—SECOND CLOSING 
 THE SECURITIES OF NIMBLEGEN SYSTEMS INC. REPRESENTED HEREBY HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED (THE “SECURITIES ACT”) OR THE SECURITIES LAWS OF ANY STATE. THE HOLDER HEREOF, BY ACCEPTING THESE SECURITIES, AGREES FOR THE BENEFIT OF NIMBLEGEN SYSTEMS INC. THAT SUCH SECURITIES MAY
BE RESOLD, PLEDGED, OR OTHERWISE TRANSFERRED ONLY (I) PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OR (II) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, AND IN EACH CASE IN ACCORDANCE WITH ANY
APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES OF AMERICA. NIMBLEGEN SYSTEMS INC. MAY REQUIRE AN OPINION OF COUNSEL SATISFACTORY TO IT THAT ANY TRANSFER IS IN COMPLIANCE WITH FEDERAL AND STATE SECURITIES LAWS AS A CONDITION TO ANY
TRANSFER OF SUCH SECURITIES. 
 THE SHARES OF STOCK OF NIMBLEGEN SYSTEMS INC. WHICH MAY BE PURCHASED UPON EXERCISE HEREOF (THE “SHARES”) WILL BE
SUBJECT TO CERTAIN RESTRICTIONS REGARDING THE RIGHT TO TRANSFER THE SHARES, CERTAIN RESTRICTIONS ON THE VOTING OF THE SHARES, AND CERTAIN OTHER PROVISIONS, ALL AS SET FORTH IN A STOCKHOLDERS AGREEMENT, AMONG NIMBLEGEN SYSTEMS INC. AND CERTAIN OF ITS
STOCKHOLDERS, AS SUCH AGREEMENT MAY BE AMENDED AND/OR RESTATED FROM TIME TO TIME. A COPY OF SUCH AGREEMENT IS AVAILABLE FOR INSPECTION AT THE PRINCIPAL OFFICE OF NIMBLEGEN SYSTEMS INC. NO TRANSFER, SALE, ASSIGNMENT, PLEDGE, HYPOTHECATION OR OTHER
DISPOSITION OF THE SHARES MAY BE MADE EXCEPT IN ACCORDANCE WITH THE PROVISIONS OF SUCH STOCKHOLDERS AGREEMENT. THE HOLDER OF THIS NOTE BY ACCEPTANCE OF THIS NOTE, AGREES TO BE BOUND BY ALL OF THE PROVISIONS OF SUCH AMENDED AND RESTATED STOCKHOLDERS
AGREEMENT. 
 NIMBLEGEN SYSTEMS INC. 
 WARRANT TO PURCHASE COMMON STOCK 
 This Warrant certifies that, for value received,
                                        
(the “Holder”) is entitled to subscribe for and purchase up to that number of shares (the “Warrant Shares”) of fully paid and nonassessable Common Stock of NimbleGen Systems Inc., a Delaware corporation (the “Company”)
equaling         % [Note: Percentage to be inserted will be the Holder’s pro rata share of the aggregate amount of Notes purchased at the Second Closing.] of the quotient of (i) [the
amount drawn under the Notes in the Second Closing, if any, which may not be more than the total principal amounts of the Notes purchased pursuant to the Purchase Agreement, as defined below, less the amount drawn under the Notes in the First
Closing and the Supplemental 

  

 45 

 
Closing, if any] divided by (ii) the most recent price per share at which the outstanding Subordinated Convertible Notes of the Company (the
“Notes”) issued pursuant to the Purchase Agreement, as defined below, were converted into Preferred or Common Stock of the Company; or, if the Notes were not converted prior to the Repayment Date as defined in the Notes, the price paid per
share of Series D Preferred Stock of the Company pursuant to the Series D Preferred Stock Purchase Agreement dated March 4, 2003 (as applicable, the “Per Share Price”), at the Warrant Price (as defined in Section 2 hereof),
subject to the provisions and upon the terms and conditions hereinafter set forth. This Warrant is issued pursuant to the terms of the Subordinated Convertible Note and Warrant Purchase Agreement dated as of May     , 2004
among the Company, the Holder and certain other parties (the “Purchase Agreement”). Unless otherwise indicated below, all capitalized terms used in this Warrant but not defined herein shall have the meanings set forth in the Purchase
Agreement. For purposes hereof, the number of shares of Common Stock purchasable upon the exercise hereof shall be referred to herein individually as a “Warrant Share” and collectively as the “Warrant Shares.” 
 1. Term of Warrant. 
 (a) The purchase right represented by this warrant (hereinafter the “Warrant”) is exercisable, in whole or in part, at any time during the term (the “Term”) commencing immediately after the closing of a Financing in
which Notes are converted, or upon receipt of a notice as provided for in Section 1(b) hereof and ending upon the earlier of (i) 5:00 p.m., Milwaukee, Wisconsin time, on April 30, 2014, or (ii) the termination of this Warrant as
provided in Section 1(b) hereof. 
 (b) In the event of the consummation of a Qualified IPO or a Change in Control, as
defined below, (a “Termination Event”), this Warrant shall terminate immediately prior to such Termination Event (the “Effective Date”) and become null and void; provided, however, that if this Warrant shall not have otherwise
terminated or expired, the Company shall give the Holder notice of the Effective Date as soon as practicable and in any event not less than 20 days prior to the Effective Date and the Holder shall have the right until 5:00 p.m., Milwaukee, Wisconsin
time, on the day immediately prior to the Effective Date to exercise its rights hereunder to the extent not previously exercised. 
 2.
Warrant Price. The initial exercise price of this Warrant is $0.01 per share, subject to adjustment from time to time pursuant to the provisions of Section 5 hereof (the “Warrant Price”). 
 3. Exercise. The purchase right represented by this Warrant may be exercised by the Holder during the Term, in whole or in part, by the surrender
of this Warrant (with the notice of exercise form attached hereto as Exhibit 1 duly executed) at the principal office of the Company and by the payment to the Company, by check, wire transfer, cancellation of indebtedness or other obligations
of the Company to the Holder or a combination of the foregoing types of consideration, of an amount equal to the then applicable Warrant Price per share multiplied by the number of Warrant Shares then being purchased. The Company agrees that the
Warrant Shares so purchased shall be deemed to be issued to the Holder as the record owner of such Warrant Shares as of the close of business on the 

  

 46 

 
date on which this Warrant shall have been surrendered and payment made for such Warrant Shares as aforesaid. In the event of any exercise of this Warrant,
certificates for the Warrant Shares of stock so purchased shall be delivered to the Holder within 5 business days thereafter and, unless this Warrant has been fully exercised or expired, a new Warrant representing the portion of the Warrant Shares,
if any, with respect to which this Warrant shall not then have been exercised, shall also be issued to the Holder within such 5 business day period. 
 4. Stock Fully Paid, Reservation of Shares. All Common Stock which may be issued upon the exercise of this Warrant will, upon issuance, be fully paid and nonassessable, except as provided in
Section 180.0622(2)(b) of the Wisconsin Statutes. During the period within which the rights represented by this Warrant may be exercised, the Company will at all times have authorized, and reserved for the purpose of the issuance upon exercise
of the purchase rights evidenced by this Warrant and the Common Stock issuable upon such exercise or conversion, a sufficient number of shares of its Common Stock to provide for the exercise of the rights represented by this Warrant. 
 5. Adjustments. The kind of securities purchasable upon the exercise of this Warrant, the Warrant Price and the number of Warrant Shares
purchasable upon exercise of this Warrant shall be subject to adjustment from time to time upon the occurrence of certain events as set forth in this Section 5. Upon each adjustment of the Warrant Price under Sections 5(b) or 5(c) hereof, the
aggregate number of Warrant Shares acquirable upon exercise of this Warrant shall be adjusted to the number of shares determined by multiplying the Warrant Price in effect immediately prior to such adjustment by the number of Warrant Shares
acquirable upon exercise of this Warrant immediately prior to such adjustment, and dividing the product hereof by the Warrant Price resulting from such adjustment. 
 (a) Waiver of Adjustment to Warrant Price. Notwithstanding anything herein to the contrary, the operation of, and any adjustment of the Warrant Price or the number of Warrant Shares pursuant to, this
Section 5 may be waived by the Holder. Any waiver pursuant to this Section 5(a) shall bind all future holders of this Warrant. 
 (b) Adjustment for Subdivisions, Combinations or Consolidations of Common Stock. If the Company subdivides or combines its outstanding shares of Common Stock into a larger or smaller number of shares of Common Stock, the Warrant
Shares for which this Warrant may be exercised shall be increased or reduced, as of the record date for such subdivision or combination, in the same proportion as the increase or decrease in the outstanding shares of Common Stock, and the Warrant
Price shall remain the same so that the aggregate amount payable for the purchase of all Warrant Shares issuable hereunder immediately after the record date for such recapitalization shall equal the aggregate amount so payable immediately before
such record date. Any adjustment under this Section 5(b) shall become effective at the close of business on the date the subdivision or combination becomes effective. 
 (c) Adjustment for Certain Dividends and Distributions. If the Company declares a dividend on shares of Common Stock, or makes a distribution to
holders of shares of Common Stock, and such dividend or distribution is payable or made in shares of Common Stock or securities convertible into or exchangeable for shares of Common Stock, or rights to purchase shares of Common Stock or securities
convertible into or exchangeable for shares of Common Stock, the Warrant Shares for which this Warrant may be 

  

 3 

 
exercised shall be increased, as of the record date for determining which holders of shares of Common Shares shall be entitled to receive such dividend or
distribution, in proportion to the increase in the number of outstanding shares of Common Stock (and shares of Common Stock issuable upon conversion of all such securities convertible into shares of Common Stock) as a result of such dividend or
distribution, and the Warrant Price shall remain the same so that the aggregate amount payable for the purchase of all the Warrant Shares issuable hereunder immediately after the record date for such dividend or distribution shall equal the
aggregate amount so payable immediately before such record date. 
 (d) Adjustments for Dividends and Distributions other than Common
Stock. In the event the Company at any time or from time to time after the date of this Warrant shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Company other than shares of Common Stock (other than as otherwise adjusted in this Section 5), then and in each such event provision shall be made so that the Holder shall receive upon exercise hereof in addition
to the number of shares of Common Stock receivable thereupon, the amount of securities of the Company that the Holder would have received had this Warrant been exercised on the date of such event and had thereafter, during the period from the date
of such event to and including the date of exercise of this Warrant, retained such securities receivable by the Holder as aforesaid during such period giving application to all adjustments called for during such period (subject to all other
adjustments called for during such period under this Section 5), under this Section 5(d) with respect to the rights of the Holder. 
 (e) Adjustment for Reclassification, Exchange, or Substitution. In the event that at any time or from time to time after the date of this Warrant, the Common Stock issuable upon the exercise of this Warrant shall be changed into the
same or a different number of shares of any class or classes of stock, whether by capital reorganization, reclassification, or otherwise (other than an event provided for in Section 5(b) through Section 5(d)), above, the Warrant Price and
the number of Warrant Shares then in effect shall, concurrently with the effectiveness of such reorganization or reclassification, be proportionately adjusted such that the Warrant shall be exercisable for, in lieu of the number of shares of Common
Stock which the holder would otherwise have been entitled to receive, a number of shares of such other class or classes of stock equivalent to the number of shares of Common Stock that would have been subject to receipt by the Holder upon exercise
of this Warrant immediately before that change. 
 (f) Adjustments to Conversion Price. To the extent the Conversion Price as provided
in the Certificate with respect to: 
 (iii) the series or class of Preferred Stock issued by the Company in the Next
Preferred Stock Offering; or 
 (iv) if the Notes were not converted prior to the Repayment Date as defined in the Notes, the
Series D Preferred Stock 
 is adjusted pursuant to the provisions of the Certificate, then the Per Share Price used to determine the number of Warrant
Shares shall be adjusted in the same manner. 
  

 4 

 (g) Adjustment of Number of Outstanding Warrant Shares. In connection with any event which would
have the effect of increasing the number of Warrant Shares which would be issuable upon exercise of this Warrant, the Company shall issue to each holder of shares of Common Stock previously obtained upon exercise of this Warrant, the number of
shares of Common Stock which, when added to the number of shares of Common Stock previously obtained by such Holder upon exercise of this Warrant would equal the product of (i) the number of such shares of Common Stock previously obtained by
such holder upon exercise of this Warrant multiplied by (ii) the quotient of (A) the number of shares of Common Stock which would have been obtainable upon exercise of this Warrant after giving effect to such adjustment, divided by
(B) the number of shares of Common Stock which would have been obtainable upon exercise of this Warrant prior to giving effect to such adjustment. 
 (h) Closing of Books. The Company shall at no time close its transfer books against the transfer of any shares of Common Stock issued or issuable upon the exercise of this Warrant in any manner which interferes
with the timely conversion of such Warrant. 
 (i) Intent of Adjustment. If, pursuant to the provisions of this Section 5, an
event would cause an adjustment to be made to the Warrant Shares or the Warrant Price under more than one subsection of this Section 5, such event shall adjust the Warrant Shares and the Warrant Price only once and such subsections will not be
read so as to cause duplicate adjustments to the Warrant Shares or the Warrant Price, as the case may be, as a result of such event. 
 6.
Notice of Adjustments. Whenever the Warrant Price or Warrant Shares shall be adjusted pursuant to Section 5 hereof, the Company shall prepare a certificate signed by its Chief Financial Officer setting forth, in reasonable detail, the
event requiring the adjustment, the amount of the adjustment, the method by which such adjustment was calculated, the Warrant Price and number of Warrant Shares purchasable upon exercise hereof after giving effect to such adjustment and the number
of shares then purchasable upon exercise of this Warrant, and shall cause copies of such certificate to be mailed (by first class mail, postage prepaid) to the Holder at the address of the Holder on the signature page to the Purchase Agreement.

 7. Fractional Shares. No fractional shares of Common Stock will be issued in connection with any exercise or conversion hereunder,
but in lieu of such fractional shares the Company shall make a cash payment therefor upon the basis of the Warrant Price then in effect. 
 8. Rights of Shares of Common Stock. The shares of Common Stock issued in connection with the exercise of the Warrant will be subject to the rights, preferences and limitations with respect to such class and series as are set forth
in the Certificate and will be subject to the provisions of the Stockholders Agreement, as such agreement may be amended from time to time and the Company’s Third Amended and Restated Registration Rights Agreement or such agreement may be
amended from time to time (the “Registration Rights Agreement”). As a condition to the receipt of any of the shares of Common Stock upon the exercise hereof, the Holder agrees to execute and deliver any counterpart signature pages or
amendments to the Stockholders Agreement and the Registration Rights Agreement which are approved and agreed to by the other stockholders of the Company. 

 5 

 9. Securities Law Compliance. The Holder, by acceptance hereof, agrees that this Warrant and the
Warrant Shares to be issued upon exercise or conversion hereof are being acquired for investment pursuant to the provisions of the Purchase Agreement, including without limitation, the representations and warranties set forth in Section 4,
thereof. 
 10. Transfer of Warrant. This Warrant and the rights granted hereunder may not be transferred or succeeded to by any
person without prior written notice to the Company describing briefly the manner of transfer, together with a written opinion of Holder’s counsel, or other evidence, if reasonably satisfactory to the Company, to the effect that such offer, sale
or other distribution may be effected without registration or qualification under any federal or state law then in effect, including without limitation, the Securities Act of 1933, as amended (the “Act”). Upon receiving such written notice
and reasonable satisfactory opinion or other evidence, the Company, as promptly as practicable but no later than fifteen (15) days after receipt of the written notice, shall notify the Holder that such Holder may sell or otherwise dispose of
this Warrant, all in accordance with the terms of the notice delivered to the Company; provided, however, that this Warrant may not be transferred to a person deemed by the Board of Directors of the Company, in its reasonable judgment, to be a
competitor or potential competitor of the Company. If a determination has been made pursuant to this Section 10 that the opinion of counsel for the Holder or other evidence is not reasonably satisfactory to the Company, the Company shall so
notify the Holder promptly with details thereof after such determination has been made. Notwithstanding the foregoing, this Warrant may, as to such federal laws, be offered, sold or otherwise disposed of in accordance with Rule 144 or 144A
under the Act, provided that the Company shall have been furnished with such information as the Company may reasonably request to provide a reasonable assurance that the provisions of Rule 144 or 144A have been satisfied and subject to the
proviso above limiting transfers to competitors. Notwithstanding the foregoing, the Holder may transfer the rights granted hereunder, without the consent of the Company, to (i) any general or limited partner, member, officer or other Affiliate
of the Holder or (ii) any entity or organization of which the Holder is a general or limited partner, member, officer or other Affiliate. Subject to compliance with the foregoing sentence, this Warrant and all rights hereunder shall be
transferable, in whole or in part, at the principal office of the Company by the Holder in person or by its duly authorized attorney, upon surrender of this Warrant properly endorsed. The last holder of this Warrant as registered on the books of the
Company may be treated by the Company and all persons dealing with this Warrant as the absolute owner hereof for any purposes and as the person entitled to exercise the rights represented by this Warrant or to transfer hereof on the books of the
Company, any notice to the contrary notwithstanding, unless and until such holder seeks to transfer registered ownership of this Warrant on the books of the Company and such transfer is effected. 
 11. Definitions. The following terms are used and not otherwise defined herein: 
 (a) Affiliate. The term “Affiliate” shall mean, as to any Person, any other Person (i) that directly or indirectly controls, is
controlled by, or is under direct or indirect common control with, such Person, (ii) that directly or indirectly owns 5% or more of the Voting Power of such Person, (iii) 5% or more of the Voting Power of which is directly or indirectly
owned by such Person, or (iv) that has the power directly or indirectly to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or otherwise. 
  

 6 

 (b) Certificate. The term “Certificate” shall mean the Company’s Third Amended and
Restated Certificate of Incorporation, as amended by that certain Certificate of Amendment dated as of February 4, 2004 and as may be amended or restated from time to time. 
 (c) Change in Control. The term “Change in Control” shall have the same meaning as is ascribed to such term in the Notes. 
 (d) Common Stock. The term “Common Stock” shall mean the $.001 par value common stock of the Company. 
 (e) Person. The term “Person” shall mean any individual, corporation, limited liability company, partnership, joint venture,
association, joint stock company, trust, unincorporated organization, governmental authority or any other form of entity. 
 (f) Qualified
IPO. The term “Qualified IPO” shall have the meaning set forth in the Certificate. 
 (g) Voting Power. The term
“Voting Power” shall mean, with respect to any Person, the power to vote for or designate members of the board of directors, the manager or a similar person or group, whether exercised by virtue of the record ownership of securities, under
a close corporation or similar agreement or under an irrevocable proxy. 
 12. Miscellaneous. 
 (a) No Rights as Stockholder. Except as may be set forth in other instruments or agreements to which the Holder is a party, the Holder shall not be
entitled to vote or receive dividends or be deemed the holder of Common Stock or any other securities of the Company which may at any time be issuable on the exercise or conversion hereof for any purpose, nor shall anything contained herein be
construed to confer upon the Holder, as such, any of the rights of a stockholder of the Company or any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold consent to
any corporate action (whether upon any recapitalization, issuance of stock, reclassification of stock, change of par value or change of stock to no par value, consolidation, merger, conveyance or otherwise) or to receive notice of meetings, or to
receive dividends or subscription rights or otherwise until the Warrant shall have been exercised or converted and the shares purchasable upon the exercise or conversion hereof shall have become deliverable, as provided herein. 
 (b) Replacement. On receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and,
in the case of loss, theft or destruction, on delivery of an indemnity agreement or bond reasonably satisfactory in form and amount to the Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company, at its
expense, will execute and deliver, in lieu of this Warrant, a new Warrant of like tenor. 
 (c) No Impairment. The Company will not,
by amendment of its Certificate or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms to be observed or performed hereunder by the Company, but will at all times in good faith assist in the carrying out of all the provisions in the Warrant (including, but not limited to, Section 5 hereof). 
  

 7 

 (d) Amendment, Modification or Restatement. The parties may, by mutual agreement, amend, modify or
restate any provision or the entirety of this Warrant, provided that each such amendment, modification or restatement shall be in writing and shall be executed and delivered by each party. 
 (e) Severability. If any provision of this Warrant is held to be invalid, void or unenforceable for any reason, the remaining provisions shall
nevertheless continue in full force and effect, provided that nothing in this Section 12(e) shall be construed to limit or waive the breach of any representation with respect to enforceability of this Warrant. 
 (f) Third Party Beneficiaries. The obligations of each party under this Warrant shall inure solely to the benefit of the other parties, and no
other Person shall have any legal or equitable right, remedy, or claim under or with respect to this Warrant. 
 (g) Notice. Any
notices required or permitted to be given under this Warrant shall be given and received in accordance with the provisions of Section 7.8 of the Purchase Agreement. 
 (h) Assignment. Subject to the restrictions on transfer described in Section 10, above, the rights and obligations of the Company and the Holder shall be binding upon and benefit the successors, assigns
and transferees of the parties. 
 (i) Further Assurances. Each party hereto agrees to execute and deliver such further documents and
instruments and to do such further acts and things as may be necessary or desirable to carry out the intent and purposes of this Warrant. 
 (j) Governing Law. This Warrant shall be governed by and construed in accordance with the laws of the State of Wisconsin without regard to conflicts of law principles thereunder. 
  

 8 

 IN WITNESS WHEREOF, this Warrant is executed as of this      day of
            , 2004. 
  

			
	 NIMBLEGEN SYSTEMS INC.

		
	By:	 	  

	Name:	 	  

	Title:	 	  

 Accepted and agreed to the      day of
            , 2004. 
  

			
	 [Name of Holder]

		
	 By:
	 	  

		 	(Title)

  

 9 

 EXHIBIT 1 
 NOTICE OF EXERCISE 
  

	TO:	NIMBLEGEN SYSTEMS INC. 

 1. The undersigned hereby elects
to purchase shares of Common Stock of NIMBLEGEN SYSTEMS INC. pursuant to the terms of the attached Warrant, and tenders herewith payment of the purchase price of such shares in full. 
 2. Please issue a certificate or certificates representing said shares of Common Stock in the name of the undersigned or in such other name as is
specified below: 
  

	
	  

	(Name)

  

	
	  

  

	
	  

	(Address)

 3. The undersigned represents that the aforesaid shares of Common Stock are being acquired for the
account of the undersigned for investment and not with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares. 
  

	
	  

	Signature

 EXHIBIT C 
 SUBJECT SECURITIES 
 PURCHASED AT THE FIRST CLOSING 
  

										
	 Purchaser
	  	Principal Amount of
Note Purchased	  	Percentage to be Inserted in
Warrants Issued	 	 	Aggregate Purchase
Price
	 780 Partners
	  	$	47,170	  	5.66	%	 	$	47,170
	 Frederick R. Blattner
	  	$	62,893	  	7.55	%	 	$	62,893
	 Baird Venture Partners I Limited Partnership
	  	$	55,485	  	6.66	%	 	$	55,485
	 BVP I Affiliates Fund Limited Partnership
	  	$	38,855	  	4.66	%	 	$	38,855
	 FHF Partners
	  	$	47,170	  	5.66	%	 	$	47,170
	 Roland Green
	  	$	5,660	  	0.68	%	 	$	5,660
	 Ice Nine Investments, LLC
	  	$	1,415	  	0.17	%	 	$	1,415
	 Emile Nuwaysir
	  	$	1,415	  	0.17	%	 	$	1,415
	 Frank V. Sica
	  	$	47,170	  	5.66	%	 	$	47,170
	 Skyline Venture Partners Qualified Purchaser II, L.P.
	  	$	104,258	  	12.51	%	 	$	104,258
	 Skyline Venture Partners II, L.P.
	  	$	8,950	  	1.07	%	 	$	8,950
	 David Sneider
	  	$	5,660	  	0.68	%	 	$	5,660
	 State of Wisconsin Investment Board
	  	$	125,786	  	15.09	%	 	$	125,786
	 Tactics II LLC
	  	$	47,170	  	5.66	%	 	$	47,170
	 Michael Treble
	  	$	15,723	  	1.89	%	 	$	15,723
	 Venture Investors Early Stage Fund III Limited Partnership
	  	$	157,233	  	18.87	%	 	$	157,233
	 Wisconsin Alumni Research Foundation
	  	$	61,321	  	7.36	%	 	$	61,321
	 Stanley D. Rose
	  	$	0	  	0	%	 	$	0
	 Rodney Wallace
	  	$	0	  	0	%	 	$	0
	 Steven Smith
	  	$	0	  	0	%	 	$	0
	 Dan Clutter
	  	$	0	  	0	%	 	$	0
		  	 	 	  	 	 	 	 	 
	 TOTAL
	  	$	833,333	  	100	%	 	$	833,333
		  	 	 	  	 	 	 	 	 

 EXHIBIT D 
 SUBJECT SECURITIES 
 PURCHASED AT THE SECOND CLOSING 
  

										
	 Purchaser
	  	Principal Amount of
Note Purchased	  	Percentage to be Inserted in
Warrants Issued	 	 	Aggregate Purchase
Price
	 780 Partners
	  	$	94,340	  	5.66	%	 	$	94,340
	 Frederick R. Blattner
	  	$	125,786	  	7.55	%	 	$	125,786
	 Baird Venture Partners I Limited Partnership
	  	$	110,970	  	6.66	%	 	$	110,970
	 BVP I Affiliates Fund Limited Partnership
	  	$	77,709	  	4.66	%	 	$	77,709
	 FHF Partners
	  	$	94,340	  	5.66	%	 	$	94,340
	 Roland Green
	  	$	11,321	  	0.68	%	 	$	11,321
	 Ice Nine Investments, LLC
	  	$	2,830	  	0.17	%	 	$	2,830
	 Emile Nuwaysir
	  	$	2,830	  	0.17	%	 	$	2,830
	 Frank V. Sica
	  	$	94,340	  	5.66	%	 	$	94,340
	 Skyline Venture Partners Qualified Purchaser II, L.P.
	  	$	208,515	  	12.51	%	 	$	208,515
	 Skyline Venture Partners II, L.P.
	  	$	17,900	  	1.07	%	 	$	17,900
	 David Sneider
	  	$	11,321	  	0.68	%	 	$	11,321
	 State of Wisconsin Investment Board
	  	$	251,572	  	15.09	%	 	$	251,572
	 Tactics II LLC
	  	$	94,340	  	5.66	%	 	$	94,340
	 Michael Treble
	  	$	31,447	  	1.89	%	 	$	31,447
	 Venture Investors Early Stage Fund III Limited Partnership
	  	$	314,465	  	18.87	%	 	$	314,465
	 Wisconsin Alumni Research Foundation
	  	$	122,642	  	7.36	%	 	$	122,642
	 Stanley D. Rose
	  	$	0	  	0	%	 	$	0
	 Rodney Wallace
	  	$	0	  	0	%	 	$	0
	 Steven Smith
	  	$	0	  	0	%	 	$	0
	 Dan Clutter
	  	$	0	  	0	%	 	$	0
		  	 	 	  	 	 	 	 	 
	 TOTAL
	  	$	1,666,667	  	100	%	 	$	1,666,667
		  	 	 	  	 	 	 	 	 

  

 EXHIBIT E 
 THIRD AMENDED AND RESTATED CERTIFICATE OF INCORPORATION, AS AMENDED 
 See attached. 

 THIRD AMENDED AND RESTATED 
 CERTIFICATE OF INCORPORATION 
 OF 
 NIMBLEGEN SYSTEMS INC. 
 The
undersigned officers of NimbleGen Systems Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, originally incorporated on August 25, 2000, do hereby certify as follows:

 1. Pursuant to the unanimous written consent of the Board of Directors and the holders of all of the issued and outstanding voting stock of
the corporation, the following resolutions were duly adopted approving the amendment and restatement of Article I through VIII of the Certificate of Incorporation of NimbleGen Systems Inc.: 
 ARTICLE I 
 The name of the corporation is
NimbleGen Systems Inc. 
 ARTICLE II 
 The address of the registered office of the corporation is 1209 Orange Street, Wilmington, New Castle County, Delaware. The name of its registered agent at such address is The Corporation Trust Company. 
 ARTICLE III 
 The purpose of the corporation
is to engage in any lawful act or activity for which corporations may be organized under the General Corporation Law of Delaware. 
 ARTICLE
IV 
 A. The corporation is authorized to issue two classes of stock to be designated, respectively, “Common Stock” and
“Preferred Stock.” The total number of shares of all classes of stock that the corporation is authorized to issue is 17,225,465 shares. The total number of shares of Common Stock that the corporation is authorized to issue is 9,895,821
with a par value of $0.001 per share. The total number of shares of Preferred Stock that the corporation is authorized to issue is 7,329,644 with a par value of $0.001 per share, of which 1,230,001 shares shall be designated as “Series A
Preferred Stock”, of which 2,080,000 shares shall be designated as “Series B Preferred Stock”, of which 1,035,715 shares shall be designated as “Series C Preferred Stock”, and of which 2,983,928 shares shall be
designated as “Series D Preferred Stock.” Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, and Series D Preferred Stock are referred to herein collectively as “Preferred
Stock.” 
  

 B. A statement of rights, preferences, privileges and restrictions granted to or imposed upon the Common
Stock and the Preferred Stock and the holders thereof is as follows: 
 1. Dividends. 
 (a) Series A Preferred Stock. The holders of the Series A Preferred Stock shall be entitled to receive, when, as and if
declared by the board of directors, out of any funds legally available therefor, noncumulative dividends at the rate per share of Series A Preferred Stock of $0.24 per annum (as adjusted for any stock dividends, combinations, splits,
recapitalizations and the like with respect to such shares) (the “Series A Preferred Annual Dividend”). So long as the Series A Preferred Stock shall be outstanding, no dividend shall be paid on the Common Stock, the
Series B Preferred Stock, the Series C Preferred Stock, or the Series D Preferred Stock in any year, other than dividends payable solely in capital stock, until the Series A Preferred Annual Dividend has been paid in full, except
that dividends may be declared and paid on the Series B Preferred Stock, the Series C Preferred Stock, and the Series D Preferred Stock pro rata with any dividends simultaneously declared and paid on Series A Preferred Stock.

 (b) Series B Preferred Stock. The holders of the Series B Preferred Stock shall be entitled to receive,
when, as and if declared by the board of directors, out of any funds legally available therefor, noncumulative dividends at the rate per share of Series B Preferred Stock of $0.40 per annum (as adjusted for any stock dividends, combinations,
splits, recapitalizations and the like with respect to such shares) (the “Series B Preferred Annual Dividend”). So long as the Series B Preferred Stock shall be outstanding, no dividend shall be paid on the Common Stock, the
Series A Preferred Stock, the Series C Preferred Stock, or the Series D Preferred Stock in any year, other than dividends payable solely in capital stock, until the Series B Preferred Annual Dividend has been paid in full, except
that dividends may be declared and paid on the Series A Preferred Stock , the Series C Preferred Stock, and the Series D Preferred Stock pro rata with any dividends simultaneously declared and paid on Series B Preferred Stock.

 (c) Series C Preferred Stock. The holders of the Series C Preferred Stock shall be entitled to receive,
when, as and if declared by the board of directors, out of any funds legally available therefor, noncumulative dividends at the rate per share of Series C Preferred Stock of $0.448 per annum (as adjusted for any stock dividends, combinations,
splits, recapitalizations and the like with respect to such shares) (the “Series C Preferred Annual Dividend”). So long as the Series C Preferred Stock shall be outstanding, no dividend shall be paid on the Common Stock, the
Series A Preferred Stock, the Series B Preferred Stock or the Series D Preferred Stock in any year, other than dividends payable solely in capital stock, until the Series C Preferred Annual Dividend has been paid in full, except
that dividends may be declared and paid on the Series A Preferred Stock, Series B Preferred Stock and the Series D Preferred Stock pro rata with any dividends simultaneously declared and paid on Series C Preferred Stock.

  

 (d) Series D Preferred Stock. The holders of the Series D Preferred
Stock shall be entitled to receive, when, as and if declared by the board of directors, out of any funds legally available therefor, noncumulative dividends at the rate per share of Series D Preferred Stock of $0.336 per annum (as adjusted for
any stock dividends, combinations, splits, recapitalizations and the like with respect to such shares) (the “Series D Preferred Annual Dividend”). So long as the Series D Preferred Stock shall be outstanding, no dividend shall be
paid on the Common Stock, the Series A Preferred Stock, the Series B Preferred Stock or the Series C Preferred Stock in any year, other than dividends payable solely in capital stock, until the Series D Preferred Annual Dividend
has been paid in full, except that dividends may be declared and paid on the Series A Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock pro rata with any dividends simultaneously declared and paid on
Series D Preferred Stock. 
 2. Liquidation Preference. 
 (a) Preferred Stock. In the event of any liquidation, dissolution or winding up of the corporation, prior and in preference to any
distribution of any of the assets or funds of the corporation to the holders of the Common Stock by reason of their ownership of such stock, the holders of Preferred Stock shall be entitled to receive the following: 
 (1) the holders of Series D Preferred Stock shall be entitled to receive, prior to the payment of any amounts to the holders of
Series A Preferred Stock, Series B Preferred Stock or Series C Preferred Stock for each outstanding share of Series D Preferred Stock then held an amount equal to $4.20 per share (as adjusted for any stock dividends,
combinations, splits, recapitalizations and the like with respect to such shares), plus any declared but unpaid dividends on such share, and 
 (2) after payment of any amount due to the holders of Series D Preferred Stock under subparagraph (1), above, the holders of Series A Preferred Stock shall be entitled to receive for each outstanding
share of Series A Preferred Stock then held, $3.00 per share (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like with respect to such shares), plus declared but unpaid dividends on such share, the holders
of Series B Preferred Stock shall be entitled to receive for each outstanding share of Series B Preferred Stock then held, $5.00 per share (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like with
respect to such shares), plus declared but unpaid dividends on such share, and the holders of Series C Preferred Stock shall be entitled to receive for each outstanding share of Series C Preferred Stock then held, $5.60 per share (as
adjusted for any stock dividends, combinations, splits, recapitalizations and the like with respect to such shares), plus declared but unpaid dividends on such share. If, upon the occurrence of a liquidation, dissolution or winding up, the assets
and funds of the corporation legally available for distribution to stockholders by reason of their ownership of stock of the corporation shall be insufficient to permit the payment to such holders of Series A Preferred Stock, 

 
Series B Preferred Stock, and Series C Preferred Stock of the full aforementioned preferential amount under this subparagraph (2), then the
entire assets and funds of the corporation legally available for distribution to stockholders by reason of their ownership of stock of the corporation shall be distributed ratably among the holders of Series A Preferred Stock, Series B
Preferred Stock, and Series C Preferred Stock, based upon the total preferential amount each holder would be entitled to receive if sufficient funds were legally available to pay the full preferential amounts. 
 (b) Common Stock. Upon a liquidation, dissolution or winding up of the corporation, and after payment to the holders of Preferred
Stock of the amounts to which they are entitled pursuant to Section B2(a) of this Article IV, all assets and funds of the corporation that remain legally available for distribution to stockholders by reason of their ownership of stock of the
corporation shall be distributed ratably among the holders of the Common Stock in proportion to the number of shares of Common Stock held by them. 
 (c) Other Events Considered a Liquidation. For purposes of this Section B2, the following events shall be considered a liquidation of the corporation: 
 (1) any consolidation or merger of the corporation with or into any other corporation or other entity in which the corporation is not the
surviving entity, or in which the stockholders of the corporation immediately prior to such consolidation or merger own less than fifty percent (50%) of the corporation’s voting power immediately after such consolidation or merger,
excluding any consolidation or merger effected exclusively to change the domicile of the corporation (a “Merger”); or 
 (2) a sale, lease or other disposition of all or substantially all of the assets of the corporation (an “Asset Transfer”). 
 If the consideration issued in a Merger or received by the corporation in an Asset Transfer is other than cash, its value will be deemed its fair market value as determined in good faith by the board of directors. Any securities shall be
valued as follows: 
 (A) For securities not subject to investment letter or other similar restrictions on free marketability
covered by subsection (B), below: 
 (i) if traded on a securities exchange or through the Nasdaq National Market, the value
shall be deemed to be the average of the closing prices of the securities on such quotation system over the thirty-day period ending three (3) days prior to the closing; 
 (ii) if actively traded over-the-counter, the value shall be deemed to be the average of the closing bid or sale prices (whichever is
applicable) over the thirty-day period ending three (3) days prior to the closing; and 
  

 (iii) if there is no active public market the value shall be the fair market value
thereof as determined in good faith by the board of directors. 
 (B) The method of valuation of securities subject to
investment letter or other restrictions on free marketability (other than restrictions arising solely by virtue of a shareholder’s status as an affiliate or former affiliate) shall be to make an appropriate discount from the market value
determined as provided in subsection (A), above to reflect the approximate fair market value thereof, as determined by at least sixty-six and two-thirds percent (66-2/3%) of the members of the board of directors. 
 3. Voting. 
 (a) General. Except as otherwise required by law and except as provided under Section B3(b), below, each holder of Common Stock shall have one vote for each share of Common Stock so held, and each holder of Preferred Stock shall
be entitled to the number of votes equal to the whole number of shares of Common Stock into which the shares of Preferred Stock so held could be converted at the record date for determination of the stockholders entitled to vote, or, if no such
record date is established, at the date such vote is taken or any written consent of the stockholders is solicited. With respect to such vote, except as provided under Section B3(b), below, each holder of Preferred Stock shall have full voting
rights and powers equal to the voting rights and powers of the holders of Common Stock and shall be entitled, notwithstanding any provision hereof, to notice of any stockholders’ meeting in accordance with the bylaws of the Corporation. Except
as otherwise set forth herein and except as may be required by Section 242(b)(2) of the Delaware General Corporation Law, all shares of Common Stock and Preferred Stock shall vote together as a single class on all matters. 
 (b) Protective Provisions 
 (1) Protective Provisions Applicable to Series A Preferred Stock. So long as any Series A Preferred Stock shall be outstanding, the affirmative vote or written consent of the holders of more than
sixty percent (60%) of the outstanding Series A Preferred Stock voting together as a single class shall be required: 
 (i) to increase the number of authorized shares of Series A Preferred Stock or to authorize or issue any class or series of stock (other than Series B Preferred Stock, Series C Preferred Stock or Series D Preferred
Stock) having any preference or priority as to dividends, liquidation preferences, conversion rights, or voting rights, superior to or on a parity with any preference or priority over the Series A Preferred Stock; 
  

 (ii) to authorize or issue any bonds, debentures, notes or other obligations convertible
into or exchangeable for, or having option rights to purchase, any shares of stock of the corporation (other than Series B Preferred Stock, Series C Preferred Stock or Series D Preferred Stock) having any preference or priority as to
dividends, liquidation preferences, conversion rights, or voting rights, superior to or on a parity with any preference or priority over the Series A Preferred Stock; 
 (iii) to reclassify any shares of capital stock of the corporation into shares having any preference or priority as to dividends,
liquidation preferences, conversion rights, or voting rights, superior to or on a parity with any preference or priority over the Series A Preferred Stock; or 
 (iv) to amend or repeal any provision of, or add any provision to, the corporation’s Certificate of Incorporation or Bylaws if such
action would alter or change the preferences, rights, privileges or powers of, or the restrictions provided for the benefit of, the Series A Preferred Stock. 
 (2) Protective Provisions Applicable to Series B Preferred Stock. So long as any Series B Preferred Stock shall be
outstanding, the affirmative vote or written consent of the holders of more than fifty percent (50%) of the outstanding Series B Preferred Stock voting together as a single class shall be required: 
 (i) to increase the number of authorized shares of Series B Preferred Stock or to authorize or issue any class or series of stock
(other than Series B Preferred Stock, Series C Preferred Stock or Series D Preferred Stock) having any preference or priority as to dividends, liquidation preferences, conversion rights, or voting rights, superior to or on a parity
with any preference or priority over the Series B Preferred Stock; 
 (ii) to authorize or issue any bonds, debentures,
notes or other obligations convertible into or exchangeable for, or having option rights to purchase, any shares of stock of the corporation (other than Series B Preferred Stock, Series C Preferred Stock or Series D Preferred Stock)
having any preference or priority as to dividends, liquidation preferences, conversion rights, or voting rights, superior to or on a parity with any preference or priority over the Series B Preferred Stock; 
 (iii) to reclassify any shares of capital stock of the corporation into shares having any preference or priority as to dividends,
liquidation preferences, conversion rights, or voting rights, superior to or on a parity with any preference or priority of the Series B Preferred Stock; or 
  

 (iv) to amend or repeal any provision of, or add any provision to, the
corporation’s Certificate of Incorporation or By-Laws if such action would alter or change the preferences, rights, privileges or powers of, or the restrictions provided for the benefit of, the Series B Preferred Stock. 
 (3) Protective Provisions Applicable to Series C Preferred Stock. So long as any Series C Preferred Stock shall be
outstanding, the affirmative vote or written consent of the holders of more than fifty percent (50%) of the outstanding Series C Preferred Stock voting together as a single class shall be required to amend this Certificate of Incorporation
if such amendment would (i) require class voting under Section 242(b)(2) of the Delaware General Corporation Law, as amended or modified from time to time or (ii) increase the number of authorized shares of Series C Preferred
Stock. For purposes hereof, any Merger in which all holders of Preferred Stock receive the same consideration per share or the creation of any new series or classes of capital stock will not require class voting by the holders of Series C Preferred
Stock. 
 (4) Protective Provisions Applicable to Series D Preferred Stock. So long as any Series D
Preferred Stock shall be outstanding, the affirmative vote or written consent of the holders of more than fifty-five percent (55%) of the outstanding Series D Preferred Stock voting together as a single class shall be required to amend
this Certificate of Incorporation if such amendment would (i) require class voting under Section 242(b)(2) of the Delaware General Corporation Law, as amended or modified from time to time or (ii) increase the number of authorized
shares of Series D Preferred Stock. For purposes hereof, any Merger in which all holders of Preferred Stock receive the same consideration per share or the creation of any new series or classes of capital stock will not require class voting by
the holders of Series D Preferred Stock. 
 (5) Protective Provisions Applicable to Series A Preferred Stock and
Series B Preferred Stock. So long as any Series A Preferred Stock or Series B Preferred Stock shall be outstanding, the affirmative vote or written consent of the holders of more than fifty percent (50%) of the then
outstanding Series A Preferred Stock and Series B Preferred Stock voting together as a single class shall be required: 
 (i) to increase the number of authorized shares of capital stock of the corporation; 
 (ii) to effect a Merger, an
Asset Transfer, or any transaction or series of related transactions to which the corporation is a party which results in the holders of the corporation’s capital stock prior to the transaction or transactions owning less than fifty percent
(50%) of the voting power of the corporation’s capital stock after the transaction or transactions; 
  

 (iii) to declare or pay any dividend on or make any other distribution with respect to
the corporation’s capital stock; or 
 (iv) to apply assets of the corporation to the redemption, retirement, purchase
or acquisition, directly or indirectly, through subsidiaries (as defined in Section 425 of the Internal Revenue Code of 1986) or otherwise, of any shares of any class or series of Common Stock, other than pursuant to plans or agreements with
employees, officers, directors, consultants, or other persons performing services for the corporation or its subsidiaries on terms approved by the board of directors, if the number of shares of stock so redeemed retired, purchased or acquired
exceeds five percent (5%) of the total number of the then issued and outstanding shares of Common Stock and Preferred Stock. 
 (6) Protective Provisions Applicable to Common Stock and Preferred Stock. The affirmative vote or written consent of the holders of more than fifty percent (50%) of the then outstanding Common Stock and Preferred Stock voting
together as a single class shall be required: 
 (i) to increase the number of shares of authorized capital stock of the
corporation; 
 (ii) to effect a Merger, an Asset Transfer, or any transaction or series of related transactions to which the
corporation is a party which results in the holders of the corporation’s capital stock prior to the transaction or transactions owning less than fifty percent (50%) of the voting power of the corporation’s capital stock after the
transaction or transactions; 
 (iii) to declare or pay any dividend on or make any other distribution with respect to the
corporation’s capital stock; or 
 (iv) to apply assets of the corporation to the redemption, retirement, purchase or
acquisition, directly or indirectly, through subsidiaries (as defined in Section 425 of the Internal Revenue Code of 1986) or otherwise, of any shares of any class or series of Common Stock, other than pursuant to plans or agreements with
employees, officers, directors, consultants, or other persons performing services for the corporation or its subsidiaries on terms approved by the board of directors, if the number of shares of stock so redeemed retired, purchased or acquired
exceeds five percent (5%) of the total number of then issued and outstanding shares of Common Stock and Preferred Stock. 
  

 4. Conversion Rights. The holders of the Preferred Stock shall have conversion
rights as follows: 
 (a) Optional Conversion for Series A Preferred Stock. Subject to and in compliance with the
provisions of this Section B4, any shares of Series A Preferred Stock may, at the option of the holder, be converted at any time into fully paid and nonassessable shares of Common Stock. The number of shares of Common Stock to which a
holder of Series A Preferred Stock shall be entitled upon conversion shall be the product obtained by multiplying the Series A Conversion Rate then in effect by the number of shares of Series A Preferred Stock being converted. The
“Series A Conversion Rate” shall be the quotient obtained by dividing $3.00 by the Series A Conversion Price. The “Series A Conversion Price” shall initially be $3.00, which shall be adjusted from time to time as
provided below. As of the date of this Third Amended and Restated Certificate of Incorporation, the Series A Conversion Price is $3.00. 
 (b) Optional Conversion for Series B Preferred Stock. Subject to and in compliance with the provisions of this Section B4, any shares of Series B Preferred Stock may, at the option of the holder,
be converted at any time into fully paid and nonassessable shares of Common Stock. The number of shares of Common Stock to which a holder of Series B Preferred Stock shall be entitled upon conversion shall be the product obtained by multiplying
the Series B Conversion Rate then in effect by the number of shares of Series B Preferred Stock being converted. The “Series B Conversion Rate” shall be the quotient obtained by dividing $5.00 by the Series B Conversion
Price. The “Series B Conversion Price” shall initially be $5.00, which shall be adjusted from time to time as provided below. As of the date of this Third Amended and Restated Certificate of Incorporation, the Series B Conversion
Price is $4.7391. 
 (c) Optional Conversion for Series C Preferred Stock. Subject to and in compliance with the
provisions of this Section B4, any shares of Series C Preferred Stock may, at the option of the holder, be converted at any time into fully paid and nonassessable shares of Common Stock. The number of shares of Common Stock to which a
holder of Series C Preferred Stock shall be entitled upon conversion shall be the product obtained by multiplying the Series C Conversion Rate then in effect by the number of shares of Series C Preferred Stock being converted. The
“Series C Conversion Rate” shall be the quotient obtained by dividing $5.60 by the Series C Conversion Price. The “Series C Conversion Price” shall initially be $5.60, which shall be adjusted from time to time as
provided below. As of the date of this Third Amended and Restated Certificate of Incorporation, the Series C Conversion Price is $5.1435. 
 (d) Optional Conversion for Series D Preferred Stock. Subject to and in compliance with the provisions of this Section B4, any shares of Series D Preferred Stock may, at the option of the holder,
be converted at any time into fully paid and nonassessable shares of Common Stock. The number of shares of Common Stock to which a holder of Series D Preferred Stock shall be entitled upon conversion shall be the product obtained by multiplying
the Series D Conversion Rate then in effect by the number of shares of Series D Preferred 

 
Stock being converted. The “Series D Conversion Rate” shall be the quotient obtained by dividing $4.20 by the Series D Conversion Price.
The “Series D Conversion Price” shall initially be $4.20, which shall be adjusted from time to time as provided below. As of the date of this Third Amended and Restated Certificate of Incorporation, the Series D Conversion Price
is $4.20. 
 (e) Mechanics of Conversion. Each holder of Preferred Stock who desires to convert the same into shares of
Common Stock pursuant to this Section B4 shall surrender the certificate or certificates therefor, duly endorsed, at the office of the corporation or any transfer agent for the Preferred Stock, and shall give written notice to the corporation
at such office that holder elects to convert the same. Such notice shall state the number of shares of Preferred Stock being converted. Thereupon, the corporation shall promptly issue and deliver at such office to such holder a certificate or
certificates for the number of shares of Common Stock to which such holder is entitled and shall promptly pay (1) in cash or, to the extent sufficient funds are not then legally available therefor, in Common Stock (at the Common Stock’s
fair market value determined by the board of directors as of the date of such conversion), any declared and unpaid dividends on the shares of Preferred Stock being converted and (2) in cash (at the Common Stock’s fair market value
determined by the board of directors as of the date of conversion) the value of any fractional share of Common Stock otherwise issuable to such holder. Such conversion shall be deemed to have been made at the close of business on the date of such
surrender of the certificates, duly endorsed representing the shares of Preferred Stock to be converted together with such written notice, and the person entitled to receive the shares of Common Stock issuable upon such conversion shall be treated
for all purposes as the record holder of such shares of Common Stock at such time. If the conversion is in connection with an underwritten offering of securities registered pursuant to the Securities Act of 1933, as amended, the conversion may, at
the option of any holder tendering Preferred Stock for conversion, be conditioned upon the closing with the underwriters of the sale of securities pursuant to each offering, in which event the persons entitled to receive the Common Stock upon
conversion of the Preferred Stock shall not be deemed to have converted such Preferred Stock until immediately prior to the closing of such sale of securities. 
 (f) Adjustment for Stock Splits and Combinations. If the corporation shall at any time or from time to time after the date that the
first share of Series D Preferred Stock is issued (the “Original Issue Date”) effect a subdivision of the outstanding Common Stock without a corresponding subdivision of the Series A Preferred Stock, the Series B Preferred
Stock, the Series C Preferred Stock, and the Series D Preferred Stock, the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion Price, and the Series D Conversion Price, in effect
immediately before that subdivision shall each be proportionately decreased. Conversely, if the corporation shall at any time or from time to time after the Original Issue Date combine the outstanding shares of Common Stock into a smaller number of
shares without a corresponding combination of the Series A Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock, and the Series D Preferred Stock, the Series A Conversion Price, the 

 
Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price in effect immediately before the combination shall
each be proportionately increased. Any adjustment under this Section B(4)(f) shall become effective at the time the subdivision or combination becomes effective. 
 (g) Adjustment for Common Stock Dividends and Distributions. If the corporation at any time or from time to time after the Original
Issue Date makes, or fixes a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable in additional shares of Common Stock, in each such event each of the Series A Conversion
Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price that is then in effect shall be decreased as of the time of such issuance or, in the event such record date is fixed, as of the
close of business on such record date, by multiplying each of the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price then in effect by a fraction (1) the
numerator of which is the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date, and (2) the denominator of which is the total number of shares
of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date plus the number of shares of Common Stock issuable in payment of such dividend or distribution; provided, however,
that if such record date is fixed and such dividend is not fully paid or if such distribution is not fully made on the date fixed therefor, each of the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion
Price and the Series D Conversion Price shall be recomputed accordingly as of the close of business on such record date and thereafter the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion Price
and the Series D Conversion Price shall be adjusted pursuant to this Section B4(g) to reflect the actual payment of such dividend or distribution. 
 (h) Adjustment for Reclassification, Exchange and Substitution. If at any time or from time to time after the Original Issue Date, the Common Stock is changed into the same or a different number of shares of
any class or classes of stock, whether by recapitalization, reclassification or otherwise (other than a Merger or Asset Transfer or a subdivision or combination of shares or stock dividend or a reorganization, merger, consolidation or sale of assets
provided for elsewhere in this Section B4), in any such event each holder of Preferred Stock shall have the right thereafter to convert such stock into the kind and amount of stock and other securities and property receivable upon such
recapitalization, reclassification or other change by holders of the maximum number of shares of Common Stock into which such shares of Preferred Stock could have been converted immediately prior to such recapitalization, reclassification or change,
all subject to further adjustment as provided herein or with respect to such other securities or property by the terms thereof. 
 (i) Reorganizations, Mergers, Consolidations or Sales of Assets. If at any time or from time to time after the Original Issue Date, there is a capital 

 
reorganization of the Common Stock (other than a Merger or Asset Transfer or a recapitalization, subdivision, combination, reclassification, exchange or
substitution of shares provided for elsewhere in this Section B4), as a part of such capital reorganization, provision shall be made so that the holders of the Preferred Stock shall thereafter be entitled to receive upon conversion of the
Preferred Stock the number of shares of stock or other securities or property of the corporation to which a holder of the number of shares of Common Stock deliverable upon conversion would have been entitled on such capital reorganization, subject
to adjustment in respect of such stock or securities by the terms thereof. In any such case, appropriate adjustment shall be made in the application of the provisions of this Section B4(i) with respect to the rights of the holders of Preferred Stock
after the capital reorganization to the end that the provisions of this Section B4(i) (including adjustment of the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D
Conversion Price then in effect and the number of shares issuable upon conversion of the Preferred Stock) shall be applicable after that event and be as nearly equivalent as practicable. 
 (j) Sale of Shares Below Series A Conversion Price, Series B Conversion Price, Series C Conversion Price or
Series D Conversion Price. 
 (1) If at any time or from time to time after the Original Issue Date, the corporation
issues or sells or is deemed by the express provisions of this subsection (1) to have issued or sold, Additional Shares of Common Stock (as defined below), other than as a dividend or other distribution on any class of stock and other than a
subdivision or combination of shares of Common Stock, for an Effective Price (as defined below) less than the then effective Series A Conversion Price, then and in each such case the then existing Series A Conversion Price shall be
reduced, as of the opening of business on the date of such issue or sale, to a price determined by multiplying the Series A Conversion Price by a fraction (i) the numerator of which shall be (A) the number of shares of Common Stock
deemed outstanding immediately prior to such issue or sale, plus (B) the number of shares of Common Stock which the aggregate Consideration Received (as defined below) by the corporation for the total number of Additional Shares of Common Stock
so issued would purchase at such Series A Conversion Price, and (ii) the denominator of which shall be the number of shares of Common Stock deemed outstanding immediately prior to such issue or sale plus the total number of Additional
Shares of Common Stock so issued. For the purposes of the preceding sentence, the number of shares of Common Stock deemed to be outstanding as of a given date shall be the sum of (i) the number of shares of Common Stock actually outstanding,
(ii) the number of shares of Common Stock into which the then outstanding shares of Series A Preferred Stock could be converted if fully converted on the day immediately preceding the given date, and (iii) the number of shares of
Common Stock which could be obtained through the exercise or conversion of all other rights, options and convertible securities or debt 

 
instruments of the corporation outstanding on the day immediately preceding the given date, including the shares of common stock which could be obtained upon
conversion of all other series of Preferred Stock. 
 (2) If at any time or from time to time after the Original Issue Date,
the corporation issues or sells or is deemed by the express provisions of this subsection (2) to have issued or sold, Additional Shares of Common Stock, other than as a dividend or other distribution on any class of stock and other than a
subdivision or combination of shares of Common Stock, for an Effective Price less than the then effective Series B Conversion Price, then and in each such case the then existing Series B Conversion Price shall be reduced, as of the opening
of business on the date of such issue or sale, to a price determined by multiplying the Series B Conversion Price by a fraction (i) the numerator of which shall be (A) the number of shares of Common Stock deemed outstanding
immediately prior to such issue or sale, plus (B) the number of shares of Common Stock which the aggregate Consideration Received by the corporation for the total number of Additional Shares of Common Stock so issued would purchase at such
Series B Conversion Price, and (ii) the denominator of which shall be the number of shares of Common Stock deemed outstanding immediately prior to such issue or sale plus the total number of Additional Shares of Common Stock so issued. For
the purposes of the preceding sentence, the number of shares of Common Stock deemed to be outstanding as of a given date shall be the sum of (i) the number of shares of Common Stock actually outstanding, (ii) the number of shares of Common
Stock into which the then outstanding shares of Series B Preferred Stock could be converted if fully converted on the day immediately preceding the given date, and (iii) the number of shares of Common Stock which could be obtained through
the exercise or conversion of all other rights, options and convertible securities or debt instruments of the corporation outstanding on the day immediately preceding the given date, including the shares of common stock which could be obtained upon
conversion of all other series of Preferred Stock. 
 (3) If at any time or from time to time after the Original Issue Date,
the corporation issues or sells or is deemed by the express provisions of this subsection (3) to have issued or sold, Additional Shares of Common Stock, other than as a dividend or other distribution on any class of stock and other than a
subdivision or combination of shares of Common Stock, for an Effective Price less than the then effective Series C Conversion Price, then and in each such case the then existing Series C Conversion Price shall be reduced, as of the opening
of business on the date of such issue or sale, to a price determined by multiplying the Series C Conversion Price by a fraction (i) the numerator of which shall be (A) the number of shares of Common Stock deemed outstanding
immediately prior to such issue or sale, plus (B) the number of shares of Common Stock which the aggregate Consideration Received by the corporation for the total number of Additional Shares of Common Stock 

 
so issued would purchase at such Series C Conversion Price, and (ii) the denominator of which shall be the number of shares of Common Stock deemed
outstanding immediately prior to such issue or sale plus the total number of Additional Shares of Common Stock so issued. For the purposes of the preceding sentence, the number of shares of Common Stock deemed to be outstanding as of a given date
shall be the sum of (i) the number of shares of Common Stock actually outstanding, (ii) the number of shares of Common Stock into which the then outstanding shares of Series C Preferred Stock could be converted if fully converted on
the day immediately preceding the given date, and (iii) the number of shares of Common Stock which could be obtained through the exercise or conversion of all other rights, options and convertible securities or debt instruments of the
corporation outstanding on the day immediately preceding the given date, including the shares of common stock which could be obtained upon conversion of all other series of Preferred Stock. 
 (4) If at any time or from time to time after the Original Issue Date, the corporation issues or sells or is deemed by the express
provisions of this subsection (4) to have issued or sold, Additional Shares of Common Stock, other than as a dividend or other distribution on any class of stock and other than a subdivision or combination of shares of Common Stock, for an
Effective Price less than the then effective Series D Conversion Price, then and in each such case the then existing Series D Conversion Price shall be reduced, as of the opening of business on the date of such issue or sale, to a price
determined by multiplying the Series D Conversion Price by a fraction (i) the numerator of which shall be (A) the number of shares of Common Stock deemed outstanding immediately prior to such issue or sale, plus (B) the number of
shares of Common Stock which the aggregate Consideration Received by the corporation for the total number of Additional Shares of Common Stock so issued would purchase at such Series D Conversion Price, and (ii) the denominator of which
shall be the number of shares of Common Stock deemed outstanding immediately prior to such issue or sale plus the total number of Additional Shares of Common Stock so issued. For the purposes of the preceding sentence, the number of shares of Common
Stock deemed to be outstanding as of a given date shall be the sum of (i) the number of shares of Common Stock actually outstanding, (ii) the number of shares of Common Stock into which the then outstanding shares of Series D
Preferred Stock could be converted if fully converted on the day immediately preceding the given date, and (iii) the number of shares of Common Stock which could be obtained through the exercise or conversion of all other rights, options and
convertible securities or debt instruments of the corporation outstanding on the day immediately preceding the given date, including the shares of common stock which could be obtained upon conversion of all other series of Preferred Stock.

 (5) For the purpose of making any adjustment required under this Section B4(j), the consideration received by the
corporation for any 

 
issue or sale of securities (the “Consideration Received”) shall (i) to the extent it consists of cash, be computed at the net amount of cash
received by the corporation after deduction of any underwriting or similar commissions, compensation or concessions paid or allowed by the corporation in connection with such issue or sale but without deduction of any expenses payable by the
corporation, (ii) to the extent it consists of property other than cash, be computed at the fair value of that property as determined in good faith by the board of directors, and (iii) if Additional Shares of Common Stock, Convertible
Securities (as defined below) or rights or options to purchase either Additional Shares of Common Stock or Convertible Securities are issued or sold together with other stock or securities or other assets of the corporation for a consideration which
covers both, be computed as the portion of the consideration so received that may be reasonably determined in good faith by the board of directors to be allocable to such Additional Shares of Common Stock, Convertible Securities or rights or
options. 
 (6) For the purpose of the adjustment required under this Section B4(j), if the corporation issues or sells
(i) stock or other securities convertible into Additional Shares of Common Stock (such convertible stock or securities being herein referred to as “Convertible Securities”) or (ii) rights or options for the purchase of Additional
Shares of Common Stock or Convertible Securities, and if the Effective Price of such Additional Shares of Common Stock is less than the Series A Conversion Price (with respect to the provisions of Section B4(j)(1), above), the Series B
Conversion Price (with respect to the provisions of Section B4(j)(2), above), the Series C Conversion Price (with respect to the provisions of Section B4(j)(3), above) or the Series D Conversion Price (with respect to the provisions
of Section B4(j)(4), above, in each case the corporation shall be deemed to have issued at the time of the issuance of such rights or options or Convertible Securities the maximum number of Additional Shares of Common Stock issuable upon
exercise or conversion thereof and to have received as consideration for the issuance of such shares an amount equal to the total amount of the consideration, if any, received by the corporation for the issuance of such rights or options or
Convertible Securities, plus, in the case of such rights or options, the minimum amounts of consideration, if any, payable to the corporation upon the exercise of such rights or options, plus, in the case of Convertible Securities, the minimum
amounts of consideration, if any, payable to the corporation upon the conversion thereof; provided that if in the case of Convertible Securities the minimum amounts of such consideration cannot be ascertained, but are a function of antidilution or
similar protective clauses, the corporation shall be deemed to have received the minimum amounts of consideration without reference to such clauses; provided further that if the minimum amount of consideration payable to the corporation upon the
exercise or conversion of rights, options or Convertible Securities is reduced over time or on the occurrence or nonoccurrence of specified events other than by reason of antidilution 

 
adjustments, the Effective Price shall be recalculated at that time using the figure to which such minimum amount of consideration is reduced; provided
further that if the minimum amount of consideration payable to the corporation upon the exercise or conversion of such rights, options or Convertible Securities is subsequently increased, the Effective Price shall be again recalculated using the
increased minimum amount of consideration payable to the corporation upon the exercise or conversion of such rights, options or Convertible Securities. No further adjustment of the Series A Conversion Price, the Series B Conversion Price,
the Series C Conversion Price, or the Series D Conversion Price as adjusted pursuant to the foregoing, shall be made as a result of the actual issuance of Additional Shares of Common Stock on the exercise of any such rights or options or
the conversion of any such Convertible Securities. If any such rights or options or the conversion privilege represented by any such Convertible Securities shall expire without having been exercised, the Series A Conversion Price, the
Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price as adjusted pursuant to the foregoing shall be readjusted to the Series A Conversion Price, the Series B Conversion Price, the
Series C Conversion Price and the Series D Conversion Price which would have been in effect had an adjustment been made on the basis that the only Additional Shares of Common Stock so issued were the Additional Shares of Common Stock, if
any, actually issued or sold on the exercise of such rights or options or rights of conversion of such Convertible Securities, and such Additional Shares of Common Stock, if any, were issued or sold for the consideration actually received by the
corporation upon such exercise, plus the consideration, if any, actually received by the corporation for the granting of all such rights or options, whether or not exercised, plus the consideration received for issuing or selling the Convertible
Securities actually converted, plus the consideration, if any, actually received by the corporation on the conversion of such Convertible Securities, provided that such readjustment shall not apply to prior conversions of Preferred Stock.

 (7) For purposes of this Section B4(j), “Additional Shares of Common Stock” shall mean all shares of Common
Stock issued by the corporation or deemed to be issued pursuant to this Section B4(j), other than (i) shares of Common Stock issued upon conversion of the Preferred Stock, (ii) shares of Common Stock and/or options, warrants or other
Common Stock purchase rights, and the Common Stock issued pursuant to such options, warrants or other rights (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like) to employees, officers, directors, consultants,
advisors, or other persons performing services for the corporation or any subsidiary pursuant to stock purchase or stock option plans or other arrangements that are approved by the board of directors, (iii) shares of Common Stock issued to
financial institutions or other lenders or lessors in connection with leases, equipment financings, revolving lines of credit or borrowings to support working capital, or similar borrowings in the ordinary course of business as approved by the

 
board of directors, (iv) shares of Common Stock issued in connection with bona fide acquisitions, mergers or similar transactions as approved by the
board of directors, (v) shares of Common Stock issued in connection with any future licensing of technology from third parties as approved by the board of directors, (vi) shares of Common Stock issued pursuant to the exercise of options,
warrants or convertible securities outstanding as of the Original Issue Date, and (vii) shares of Common Stock issued in connection with the transactions contemplated under Sections B4(f), (g) and (h) of this Article IV. For purposes
of this Section B4(j), the “Effective Price” of Additional Shares of Common Stock shall mean the quotient determined by dividing the total number of Additional Shares of Common Stock issued or sold, or deemed to have been issued or
sold by the corporation under this Section B4(j), into the aggregate Consideration Received, or deemed to have been received by the corporation for such issue under this Section B4(j), for such Additional Shares of Common Stock. 
 (k) Certificate of Adjustment. In each case of an adjustment or readjustment of the Series A Conversion Price, the
Series B Conversion Price or the Series C Conversion Price, if the Series A Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock or the Series D Preferred Stock is then convertible pursuant to
this Section B4(k), the corporation, at its expense, shall compute such adjustment or readjustment in accordance with the provisions hereof and prepare a certificate showing such adjustment or readjustment, and shall mail such certificate, by
first class mail, postage prepaid, to each registered holder of Preferred Stock at the holder’s address as shown in the corporation’s books. The certificate shall set forth such adjustment or readjustment, showing in detail the facts upon
which such adjustment or readjustment is based, including a statement of (i) the Consideration Received or deemed to be received by the corporation for any Additional Shares of Common Stock issued or sold or deemed to have been issued or sold,
(ii) the Series A Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price at the time in effect, (iii) the number of Additional Shares of Common Stock and
(iv) the type and amount, if any, of other property which at the time would be received upon conversion of the Preferred Stock. 
 (l) Notices of Record Date. Upon (i) any taking by the corporation of a record of the holders of any class of securities for the purpose of determining the holders thereof who are entitled to receive any dividend or other
distribution, or (ii) any Merger or other capital reorganization of the corporation, any reclassification or recapitalization of the capital stock of the corporation, any merger or consolidation of the corporation with or into any other
corporation, any Asset Transfer, or any voluntary or involuntary dissolution, liquidation or winding up of the corporation, the corporation shall mail to each holder of Preferred Stock at least twenty (20) days prior to the record date
specified therein (or such shorter period approved by a majority of the outstanding shares of the Series A Preferred Stock, a majority of the outstanding shares of the Series B Preferred Stock, a majority of the outstanding shares of the
Series C Preferred Stock and a majority 

 
of the outstanding shares of Series D Preferred Stock) a notice specifying (i) the date on which any such record is to be taken for the purpose of
such dividend or distribution and description of such dividend or distribution, (ii) the date on which any such Merger, reorganization, reclassification, transfer, consolidation, merger, Asset Transfer, dissolution, liquidation or winding up is
expected to become effective, and (iii) the date, if any, that is to be fixed as to when the holders of record of Common Stock (or other securities) shall be entitled to exchange their shares of Common Stock (or other securities) for securities
or other property deliverable upon such Merger, reorganization, reclassification, transfer, consolidation, merger, Asset Transfer, dissolution, liquidation or winding up. 
 (m) Automatic Conversion. 
 (1) Each share of Series A Preferred Stock shall automatically be converted into shares of Common Stock, based on the then effective Series A Conversion Rate (i) at any time upon the affirmative
election of the holders of at least sixty percent (60%) of the outstanding shares of the Series A Preferred Stock, or (ii) immediately upon the closing of a firm commitment underwritten public offering pursuant to an effective
registration statement under the Securities Act of 1933, as amended, covering the offer and sale of Common Stock in which (A) the per share price is at least $10.50 (as adjusted for stock splits, dividends, recapitalizations and the like), and
(B) the gross proceeds to the corporation (before underwriting discounts, commissions and fees) are at least $20,000,000 (for purposes hereof, a “Qualified IPO”). Upon such automatic conversion, any declared and unpaid dividends shall
be paid in accordance with the provisions of Section B1 of this Article IV. 
 (2) Each share of Series B Preferred
Stock shall automatically be converted into shares of Common Stock, based on the then effective Series B Conversion Rate (i) at any time upon the affirmative election of the holders of more than fifty percent (50%) of the outstanding
shares of the Series B Preferred Stock, or (ii) immediately upon the closing of a Qualified IPO. Upon such automatic conversion, any declared and unpaid dividends shall be paid in accordance with the provisions of Section B1 of this
Article IV. 
 (3) Each share of Series C Preferred Stock shall automatically be converted into shares of Common Stock,
based on the then effective Series C Conversion Rate (i) at any time upon the affirmative election of the holders of more than fifty percent (50%) of the outstanding shares of the Series C Preferred Stock, or
(ii) immediately upon the closing of a Qualified IPO. Upon such automatic conversion, any declared and unpaid dividends shall be paid in accordance with the provisions of Section B1 of this Article IV. 
 (4) Each share of Series D Preferred Stock shall automatically be converted into shares of Common Stock, based on the then effective

 
Series D Conversion Rate (i) at any time upon the affirmative election of the holders of more than fifty-five percent (55%) of the outstanding
shares of the Series D Preferred Stock, or (ii) immediately upon the closing of a Qualified IPO. Upon such automatic conversion, any declared and unpaid dividends shall be paid in accordance with the provisions of Section B1 of this
Article IV. 
 (5) Upon the occurrence of either of the events specified in Section B4(m)(1), above, the outstanding
shares of Series A Preferred Stock shall be converted automatically without any further action by the holders of such shares and whether or not the certificates representing such shares are surrendered to the corporation or its transfer agent,
upon the occurrence of either of the events specified in Section B4(m)(2), above, the outstanding shares of Series B Preferred Stock shall be converted automatically without any further action by the holders of such shares and whether or
not the certificates representing such shares are surrendered to the corporation or its transfer agent, upon the occurrence of either of the events specified in Section B4(m)(3), above, the outstanding shares of Series C Preferred Stock
shall be converted automatically without any further action by the holders of such shares and whether or not the certificates representing such shares are surrendered to the corporation or its transfer agent, and upon the occurrence of either events
specified in Section B4(m)(4), above, the outstanding shares of Series D Preferred Stock shall be converted automatically without any further action by the holders of such shares and whether or not the certificates representing such shares
are surrendered by the corporation or its transfer agent; provided, however, in each case, that the corporation shall not be obligated to issue certificates evidencing the shares of Common Stock issuable upon such conversion unless the certificates
evidencing such shares of Preferred Stock are either delivered to the corporation or its transfer agent or the holder notifies the corporation or its transfer agent that such certificates have been lost, stolen or destroyed and executes an agreement
satisfactory to the corporation to indemnify the corporation from any loss incurred by it in connection with such certificates. Upon the occurrence of such automatic conversion of the Preferred Stock, the holders thereof shall surrender the
certificates representing such shares at the office of the corporation or any transfer agent for the Preferred Stock. Thereupon, there shall be issued and delivered to such holder promptly at such office and in its name as shown on such surrendered
certificate or certificates, a certificate or certificates for the number of shares of Common Stock into which the shares of Preferred Stock surrendered were convertible on the date on which such automatic conversion occurred, and any declared and
unpaid dividends shall be paid in accordance with the provisions of Section B(1) of this Article IV. 
 (n) Fractional
Shares. No fractional shares of Common Stock shall be issued upon conversion of Preferred Stock. All shares of Common Stock (including fractions thereof) issuable upon conversion of more than one share of 

 
Preferred Stock by a holder thereof shall be aggregated for purposes of determining whether the conversion would result in the issuance of any fractional
share. If, after the aforementioned aggregation, the conversion would result in the issuance of any fractional share, the corporation shall, in lieu of issuing any fractional share, pay cash equal to the product of such fraction multiplied by the
Common Stock’s fair market value (as determined by the board of directors) on the date of conversion. 
 (o)
Reservation of Stock Issuable Upon Conversion. The corporation shall at all times reserve and keep available out of its authorized but unissued shares of Common Stock, solely for the purpose of effecting the conversion of the shares of the
Preferred Stock, such number of its shares of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares of the Preferred Stock. If at any time the number of authorized but unissued shares of Common
Stock shall not be sufficient to effect the conversion of all then outstanding shares of the Preferred Stock, the corporation will take such corporate action as may, in the opinion of its counsel, be necessary to increase its authorized but unissued
shares of Common Stock to such number of shares as shall be sufficient for such purpose. 
 (p) Notices. Any notice
required by the provisions of this Section B4 shall be in writing and shall be deemed effectively given: (i) upon personal delivery to the party to be notified, (ii) when sent by confirmed telex or facsimile if sent during normal business
hours of the recipient; if not, then on the next business day, (iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (iv) one (1) day after deposit with a
nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All notices shall be addressed to each holder of record at the address of such holder appearing on the books of the corporation. 

(q) Payment of Taxes. The corporation will pay all taxes (other than taxes based upon income) and other governmental charges
that may be imposed with respect to the issue or delivery of shares of Common Stock upon conversion of shares of Preferred Stock, excluding any tax or other charge imposed in connection with any transfer involved in the issue and delivery of shares
of Common Stock in a name other than that in which the shares of Preferred Stock so converted were registered. 
 (r) No
Dilution or Impairment. Without the consent of the holders of then outstanding Preferred Stock as required under Section B4 of this Article IV., the corporation shall not amend its Certificate of Incorporation or participate in any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or take any other voluntary action, for the purpose of avoiding or seeking to avoid the observance or performance of any of the terms to be observed
or performed hereunder by the corporation, but shall at all times in good faith assist in carrying out all such action as may be reasonably necessary or appropriate in order to protect the conversion rights of the holders of the Preferred Stock
against dilution or other impairment. 
  

 5. Waiver of Rights, Preferences or Privileges. 
 (a) Series A Preferred Stock. Any right, preference or privilege which is specific to the Series A Preferred Stock may be
waived if holders of at least sixty percent (60%) of the outstanding shares of Series A Preferred Stock approve such waiver in writing, in which event such waiver shall be binding on all holders of Series A Preferred Stock.

 (b) Series B Preferred Stock. Any right, preference or privilege which is specific to the Series B
Preferred Stock may be waived if holders of more than fifty percent (50%) of the outstanding shares of Series B Preferred Stock approve such waiver in writing, in which event such waiver shall be binding on all holders of Series B
Preferred Stock. 
 (c) Series C Preferred Stock. Any right, preference or privilege which is specific to the
Series C Preferred Stock may be waived if holders of more than fifty percent (50%) of the outstanding shares of Series C Preferred Stock approve such waiver in writing, in which event such waiver shall be binding on all holders of
Series C Preferred Stock. 
 (d) Series D Preferred Stock. Any right, preference or privilege which is
specific to the Series D Preferred Stock may be waived if holders of more than sixty percent (60%) of the outstanding shares of Series D Preferred Stock approve such waiver in writing, in which event such waiver shall be binding on
all holders of Series D Preferred Stock. 
 6. United States Dollars. All references herein to “$” or
Dollars means United States dollars. 
 ARTICLE V 
 The name and address of the incorporator is Kenneth C. Hunt, 780 North Water Street, Milwaukee, Wisconsin 53202. 
 ARTICLE VI 
 Election of directors need not be by written ballot unless the Bylaws of the corporation shall so provide. 

ARTICLE VII 
 In furtherance and not in
limitation of the powers conferred by statute, the board of directors of the corporation is expressly authorized to make, alter, amend or repeal the Bylaws of the corporation. 
 ARTICLE VIII 
 A. To the fullest extent not prohibited by the General Corporation Law
of Delaware as the same exists or as it may hereafter be amended, a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for conduct as a director. 
  

 B. The corporation shall indemnify to the fullest extent not prohibited by law any person made or
threatened to be made a party to an action or proceeding, whether criminal, civil, administrative or investigative, by reason of the fact that such person is or was a director, officer, employee benefit plan fiduciary, or employee of the corporation
or any predecessor of the corporation or serves or served at the request of the corporation or any predecessor of the corporation as a director, officer, agent, employee benefit plan fiduciary or employee of another corporation, partnership, limited
liability company, joint venture, trust or other entity or enterprise. 
 C. Neither any amendment or repeal of this Article VIII, nor the
adoption of any provision of the corporation’s Certificate of Incorporation inconsistent with this Article VIII, shall eliminate or reduce the effect of this Article VIII in respect of any matter occurring, or any action or proceeding accruing
or arising or that, but for this Article VIII, would accrue or arise, prior to such amendment, repeal or adoption of an inconsistent provision. 
 2. That this Amendment and Restatement was adopted in accordance with the provisions of Sections 242 and 245 of the General Corporation Law of the State of Delaware. 
 Executed in duplicate this 4th day of March, 2003. 
  

					
	 NIMBLEGEN SYSTEMS INC.

		
	By:	 	 /s/ David C. Sneider
 David C. Sneider, Vice President and
 Chief Financial Officer

		 
		 
			
		 	 Attest:
	 	 /s/ Kenneth C. Hunt

		 		 	Kenneth C. Hunt, Secretary

 This document was drafted by: 
 Mark T. Ehrmann 
 Godfrey & Kahn, S.C. 
 780 North Water Street 
 Milwaukee, WI 53202 
  

 CERTIFICATE OF AMENDMENT 
 OF 
 THIRD AMENDED AND RESTATED CERTIFICATE OF INCORPORATION 
 OF 
 NIMBLEGEN SYSTEMS INC.

 NimbleGen Systems Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of
Delaware (the “Corporation”), 
 DOES HEREBY CERTIFY: 
 FIRST: That at a meeting of the Board of Directors of NimbleGen Systems Inc. resolutions were duly adopted setting forth a proposed amendment to the Third Amended and Restated Certificate of Incorporation of said
corporation, declaring said amendment to be advisable and calling a meeting of the shareholders of said corporation for consideration thereof. The resolution setting forth the proposed amendment is as follows: 
 BE IT RESOLVED, that the Third Amended and Restated Certificate of Incorporation of NimbleGen Systems Inc. be amended by deleting Article IV A
thereof and inserting in its place the following: 
 ARTICLE IV 
 D. The corporation is authorized to issue two classes of stock to be designated, respectively, “Common Stock” and
“Preferred Stock.” The total number of shares of all classes of stock that the corporation is authorized to issue is 17,507,271 shares. The total number of shares of Common Stock that the corporation is authorized to issue is 10,137,627
with a par value of $0.001 per share. The total number of shares of Preferred Stock that the corporation is authorized to issue is 7,369,644 with a par value of $0.001 per share, of which 1,230,001 shares shall be designated as “Series A
Preferred Stock”, of which 2,080,000 shares shall be designated as “Series B Preferred Stock”, of which 1,075,715 shares shall be designated as “Series C Preferred Stock”, and of which 2,983,928 shares shall be
designated as “Series D Preferred Stock.” Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, and Series D Preferred Stock are referred to herein collectively as “Preferred
Stock.” 
 SECOND: That by written consent of the stockholders of the Corporation, resolutions were duly adopted setting forth said
amendment to the Third Amended and Restated Certificate of Incorporation in accordance with the By-Laws of the Corporation and Sections 242 and 228 of the General Corporation Law of the State of Delaware. 
 THIRD: That said amendment was duly adopted in accordance with the provisions of Sections 242 and 228 of the General Corporation Law of the State of
Delaware. 
  

 IN WITNESS WHEREOF, the undersigned has executed
this Certificate as of the 4th day of February, 2004. 
  

			
	NIMBLEGEN SYSTEMS INC.
		
	By:	 	 /s/ Kenneth C. Hunt

		 	Kenneth C. Hunt, Secretary

 This instrument was drafted by: 
 Jessica L. Braeger 
 Godfrey & Kahn, S.C. 
 780 North Water Street 
 Milwaukee, Wisconsin 53202 
  

 EXHIBIT F 
 NimbleGen Systems Inc. 
 Fully Diluted Capitalization Table 
  

																											
	 Name of Shareholder
	  	Common	  	Series A	  	Series B	  	Converted Series B	  	Series C	  	Converted Series C	  	Series D	  	Anti-Dil Adjustment	  	Total	  	% ownership	 
		  		  			  			  	1.0551	  			  	1.0888	  			  		  			  		
	Price Per Share	  		  	$	3.00	  	$	5.00	  		  	$	5.60	  		  	$	4.20	  		  			  		
	 Date
	  		  	 	Sept. 2000	  	 	Jun. 2001	  		  	 	Jan. 2002	  		  	 	Mar. 2003	  		  			  		
	 Dollars Raised
	  		  	$	3,690,003.00	  	$	10,400,000.00	  		  	$	5,799,998.00	  		  	$	8,300,002.00	  		  	$	28,190,003.00	  		
		  		  	 	 	  	 	 	  		  	 	 	  		  	 	 	  		  	 	 	  		
	 *780 Partners
	  	0.00	  	 	125,000.00	  	 	100,000.00	  	105,510.00	  	 	0.00	  	0.00	  	 	25,237.00	  	5,510.00	  	 	255,747.00	  	2.81	%
	 *Baird Venture Partners I L.P.
	  	0.00	  	 	0.00	  	 	117,627.00	  	124,108.25	  	 	0.00	  	0.00	  	 	13,163.00	  	6,481.25	  	 	137,271.25	  	1.51	%
	 *Blattner, Frederick
	  	0.00	  	 	85,000.00	  	 	30,000.00	  	31,653.00	  	 	0.00	  	0.00	  	 	9,524.00	  	1,653.00	  	 	126,177.00	  	1.39	%
	 *BVP I Affiliates Fund L.P.
	  	0.00	  	 	0.00	  	 	82,373.00	  	86,911.75	  	 	0.00	  	0.00	  	 	9,218.00	  	4,538.75	  	 	96,129.75	  	1.06	%
	 Chojnacki, Thomas P.
	  	10,000.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	10,000.00	  	0.11	%
	 *FHF Partners
	  	0.00	  	 	123,334.00	  	 	100,000.00	  	105,510.00	  	 	0.00	  	0.00	  	 	25,238.00	  	5,510.00	  	 	254,082.00	  	2.79	%
	 *Green, Roland
	  	67,500.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	67,500.00	  	0.74	%
	 *Ice Nine Investments, LLC
	  	0.00	  	 	16,667.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	16,667.00	  	0.18	%
	 *ITX International Equity Corporation
	  	0.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	714,286.00	  	0.00	  	 	714,286.00	  	7.85	%
	 *NimbleGen, Inc.
	  	427,500.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	427,500.00	  	4.70	%
	 *Nuwasir, Emile
	  	10,000.00	  	 	5,000.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	15,000.00	  	0.16	%
	 *Sica, Frank
	  	0.00	  	 	125,000.00	  	 	100,000.00	  	105,510.00	  	 	0.00	  	0.00	  	 	25,238.00	  	5,510.00	  	 	255,748.00	  	2.81	%
	 *Skyline Venture Partners Qualified Purchase Fund
	  	92,094.00	  	 	460,471.00	  	 	460,471.00	  	485,842.95	  	 	0.00	  	0.00	  	 	87,709.00	  	25,371.95	  	 	1,126,116.95	  	12.37	%
	 *Skyline Venture Partners II, L.P.
	  	7,906.00	  	 	39,529.00	  	 	39,529.00	  	41,707.05	  	 	0.00	  	0.00	  	 	7,529.00	  	2,178.05	  	 	96,671.05	  	1.06	%
	 *Sneider, David
	  	29,183.00	  	 	0.00	  	 	30,000.00	  	31,653.00	  	 	0.00	  	0.00	  	 	0.00	  	1,653.00	  	 	60,836.00	  	0.67	%
	 *Schott Nexterion AG
	  	0.00	  	 	0.00	  	 	300,000.00	  	316,530.00	  	 	1,035,715.00	  	1,127,686.49	  	 	952,381.00	  	108,501.49	  	 	2,396,597.49	  	26.32	%
	 *SWIB (State of WI Investment Board)
	  	0.00	  	 	0.00	  	 	200,000.00	  	211,020.00	  	 	0.00	  	0.00	  	 	22,381.00	  	11,020.00	  	 	233,401.00	  	2.56	%
	 *Tactics II Investments LLC
	  	405,000.00	  			  			  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	405,000.00	  	4.45	%
	 *Tactics II LLC
	  	0.00	  	 	125,000.00	  	 	100,000.00	  	105,510.00	  	 	0.00	  	0.00	  	 	25,238.00	  	5,510.00	  	 	255,748.00	  	2.81	%
	 *Treble, Michael**
	  	175,000.00	  	 	0.00	  	 	20,000.00	  	21,102.00	  	 	0.00	  	0.00	  	 	0.00	  	1,102.00	  	 	196,102.00	  	2.15	%
	 *Venture Investors Early Stage Fund III L.P.
	  	0.00	  	 	0.00	  	 	300,000.00	  	316,530.00	  	 	0.00	  	0.00	  	 	33,810.00	  	16,530.00	  	 	350,340.00	  	3.85	%
	 *WARF (WI Alumni)
	  	100,000.00	  	 	125,000.00	  	 	100,000.00	  	105,510.00	  	 	0.00	  	0.00	  	 	25,238.00	  	5,510.00	  	 	355,748.00	  	3.91	%
	 Thomas Gorski
	  	2,000.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	2,000.00	  	0.02	%
	 Renee Raffel
	  	300.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	300.00	  	0.00	%
	 Wei Huang
	  	375.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	375.00	  	0.00	%
	 David Cooper
	  	18,125.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	18,125.00	  	0.20	%
	 *Texas Instruments Incorporated
	  	66,000.00	  	 	0.00	  	 	0.00	  	0.00	  	 	13,333.00	  	14,516.97	  	 	0.00	  	1,183.97	  	 	80,516.97	  	0.88	%
	 *Board of Regents U of TX Systems
	  	39,667.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	39,667.00	  	0.44	%
	 *Garner, Harold
	  	39,667.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	39,667.00	  	0.44	%
	 Kelli Thole
	  	300.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	300.00	  	0.00	%
	 GATX Warrants
	  	0.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	13,095.00	  	0.00	  	 	13,095.00	  	0.14	%
	 ESO-Issued Not Exercised
	  	976,272.00	  	 	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	0.00	  	0.00	  	 	976,272.00	  	10.72	%
	 *Issued upon notice from Light Bio
	  	52,666.00	  	 	0.00	  	 	0.00	  	0.00	  	 	26,667.00	  	29,035.03	  	 	0.00	  	2,368.03	  	 	81,701.03	  	0.90	%
		  	 	  	 	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  	 	 
	 Total Shares and Options
	  	2,519,555.00	  	 	1,230,001.00	  	 	2,080,000.00	  	2,194,608.00	  	 	1,075,715.00	  	1,171,238.49	  	 	1,989,285.00	  	210,131.49	  	 	9,104,687.49	  	100.00	%
		  	 	  	 	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  	 	 
											
	 ESO Authorized Non-Issued
	  	38,445.00	  			  			  		  			  		  			  		  	 	38,445.00	  		
		  	 	  			  			  		  			  		  			  		  	 	 	  		
		  	2,558,000.00	  	 	1,230,001.00	  	 	2,080,000.00	  	2,194,608.00	  	 	1,075,715.00	  	1,171,238.49	  	 	1,989,285.00	  	210,131.49	  	 	9,143,132.49	  		
		  	 	  	 	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  	 	  	 	 	  		

	*	Have preemptive rights 

 EXHIBIT G 
                     , 2004 
 To the Purchasers listed on Exhibit A attached hereto 
 c/o Foley & Lardner, LLP 
 150 East Gilman 
 Madison, Wisconsin 53703 
 Ladies and Gentlemen: 
 We have acted as counsel for
NimbleGen Systems Inc., a Delaware corporation (the “Company”), in connection with the issuance and sale of subordinated convertible promissory notes in the maximum aggregate principal amount of
$             [insert aggregate principal amount of Notes issued as of the date opinion is issued] (the “Notes”) and related warrants to purchase the Company’s
Common Stock (the “Warrants”) (collectively, the “Securities”) to you (the “Purchaser”) and certain other purchasers pursuant to that certain Subordinated Convertible Promissory Note and Warrant Purchase Agreement dated
as of                     , 2004 (the “Agreement”) among the Company, you and certain other purchasers. We are rendering this
opinion pursuant to Section 6.1(g) and Section 6.2(g) of the Agreement. Except as otherwise defined herein, capitalized terms used but not defined herein have the respective meanings given to them in the Agreement. 
 In connection with this opinion, we have examined and relied upon the representations and warranties as to factual matters contained in and made pursuant
to the Agreement by the various parties and originals or copies, certified to our satisfaction, of such records, documents, certificates, opinions, memoranda and other instruments (including certificates of public officials) as in our judgment are
necessary or appropriate to enable us to render the opinions expressed below. Where we render an opinion “to our knowledge” or concerning an item “known to us” or our opinion otherwise refers to our knowledge, it is based solely
upon (i) an inquiry of attorneys within this firm who perform legal services for the Company; (ii) the statements made in a certificate in the form attached hereto as Exhibit B executed by an officer of the Company covering
such matters as described therein; (iii) our review of the books, records, agreements and other documents of the Company in our files (including the stock record book) or made available to us by the Company after diligent inquiry for purposes
of this opinion; and (iv) such other investigation, if any, that we specifically set forth herein. For purposes of the opinion in Paragraph 1, below, we have relied exclusively on a certificate from the Secretary of State of the State of
Delaware, and for purposes of the opinion in the second sentence of Paragraph 2, below, we have relied exclusively on a certificate from the Department of Financial Institutions of the State of Wisconsin. 
  

 
                                 
                     , 2004 
 Page 2 
  

 In rendering this opinion, we have assumed: the genuineness and authenticity of all signatures on
original documents (other than those of officers of the Company); the authenticity of all documents submitted to us as originals; the conformity to originals of all documents submitted to us as copies; the accuracy, completeness and authenticity of
certificates of public officials; and the due authorization, execution and delivery of all documents (except the due authorization, execution and delivery by the Company of the Agreement) where the authorization, execution and delivery are
prerequisites to the effectiveness of such documents. We have also assumed: that all individuals executing and delivering documents had the legal capacity to so execute and deliver; that the Purchaser has received all documents it was to receive
under the Agreement; that the Agreement constitutes obligations binding upon the parties thereto other than the Company; and that there are no extrinsic agreements or understandings among the parties to the Agreement that would modify or interpret
the terms of such agreements or the respective rights or obligations of the parties thereunder. 
 Our opinion is expressed only with respect
to the federal laws of the United States of America, the laws of the State of Wisconsin and the General Corporation Law of the State of Delaware. We express no opinion as to whether the laws of any particular jurisdiction apply, and no opinion to
the extent that the laws of any jurisdiction other than those identified above are applicable to the subject matter hereof. We are not rendering any opinion as to compliance with any antifraud law, rule or regulation relating to securities, or to
the sale or issuance thereof, or the compliance by the Company with any securities or “blue sky” laws of any state or other jurisdiction, except as set forth in Paragraph 8 below. 
 On the basis of the foregoing, in reliance thereon and with the foregoing qualifications and limitations, we are of the opinion that: 
  

	 	1.	The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. 

  

	 	2.	The Company has the requisite corporate power to own its property and assets and to conduct its business as it is currently being conducted, and to enter into and perform its
obligations under the Agreement. The Company is duly qualified to do business as a foreign corporation under the laws of the State of Wisconsin. To our knowledge, the Company is not required to qualify as a foreign corporation to do business in any
jurisdiction in the United States except Wisconsin. 

  

	 	3.	 The Agreement has been duly and validly executed and delivered by the Company, the execution and delivery of such agreement and the consummation by the Company of
the transactions contemplated thereby have been duly authorized by all requisite corporate action on the part of the Company, and such agreement constitutes a valid and binding agreement of the Company enforceable against the Company in accordance
with its terms, subject to applicable bankruptcy, 

  

 2 

 
                                 
                     , 2004 
 Page 3 
  

	 	 
receivership, fraudulent conveyance or transfer and other laws and judicially developed doctrines relating to or affecting creditors’ rights and
remedies and general equity principles and to limitations on availability of equitable relief, including specific performance. 

  

	 	4.	The Company’s authorized capital stock consists of (a) 10,137,627 shares of Common Stock, par value $0.001 per share, 1,542,983 shares of which, to our knowledge, are
issued and outstanding, and 1,035,017 shares of which, to our knowledge, have been authorized for issuance to officers, directors, employees, and consultants; (b) 1,230,001 shares of Series A Preferred Stock, par value $0.001 per share,
all of which, to our knowledge, are issued and outstanding; (c) 2,080,000 shares of Series B Preferred Stock, par value $0.001 per share, all of which, to our knowledge, are issued and outstanding; (d) 1,075,715 shares of Series C
Preferred Stock, par value $0.001 per share, all of which, to our knowledge, are issued and outstanding; and (e) 2,983,928 shares of Series D Preferred Stock, par value $0.001 per share, 1,976,190 of which, to our knowledge, are issued and
outstanding. To our knowledge, there are no options, warrants, conversion privileges, preemptive rights or other rights outstanding to purchase any of the authorized but unissued capital stock of the Company, other than those options set forth in
the Agreement or described in the Schedule of Exceptions to the Agreement delivered by the Company to the Purchaser, and rights created in connection with the transactions contemplated by the Agreement (including those arising out of the provisions
of the Securities), and except as provided in the Standard Equity Agreement made September 27, 1999, between the Company and the Wisconsin Alumni Research Foundation (the “WARF Equity Agreement”), the Stockholders Agreement and the
Charter. Except as described or disclosed in the Agreement and the Schedule of Exceptions thereto, the Stockholders Agreement of the Company and the Registration Rights Agreement or as provided for in the WARF Equity Agreement or the Charter, to our
knowledge, the Company has no obligation to purchase, redeem, or otherwise acquire any of its equity securities or any interest therein or to pay any dividend or make any other distribution in respect thereof. 

  

	 	5.	The execution, delivery, and performance of the Agreement and the issuance of the Securities pursuant to the Agreement, do not violate any provision of the Charter or Bylaws of the
Company, and do not constitute a material default under the provisions of any material agreement known to us to which the Company is a party or by which it is bound, and do not violate, result in the creation of imposition of any lien, charge or
encumbrance upon any property or assets of the Company under, or contravene (a) any governmental statute, rule or regulation applicable to the Company or (b) any order, writ, judgment, injunction, decree, determination or award which has
been entered against the Company and of which we are aware, the violation or contravention of which would materially and adversely affect the Company, its assets, financial condition or results of operations. 

  

 3 

 
                                 
                     , 2004 
 Page 4 
  

  

	 	6.	To our knowledge, there is no action, proceeding or investigation pending or overtly threatened against the Company before any court or administrative agency that questions the
validity of the Agreement or might result, either individually or in the aggregate, in any material adverse change in the assets, financial condition, or results of operations of the Company. 

  

	 	7.	All consents, approvals, authorizations, or orders of, and filings, registrations, and qualifications with any regulatory authority or governmental body in the United States
required for the consummation by the Company of the transactions contemplated by the Agreement, have been made or obtained except such as may be required by any applicable securities or “blue sky” laws of any state or other jurisdiction.

  

	 	8.	Based upon our assumption that the representations and warranties of each Purchaser in the Agreement are true and correct, the offer and sale of the Securities is exempt from the
registration requirements of the Securities Act of 1933, as amended, and the Wisconsin state securities laws. Other than as contained in the immediately preceding sentence, we express no opinion on the conditions under which the Securities may be
resold or as to the registration or qualification of the Securities under the securities laws of the state or states where the offer, sale, issuance, or delivery thereof occurred. 

 This opinion is intended solely for your benefit and is not to be made available to or be relied upon by any other person, firm, or entity without our
prior written consent. 
  

	
	Very truly yours,
	
	GODFREY & KAHN, S.C.

  

 4 

 EXHIBIT A 
 PURCHASERS 
 780 Partners 
 Frederick R. Blattner 
 Baird Venture Partners I Limited Partnership 
 BVP I Affiliates Fund Limited Partnership 
 FHF Partners 
 Roland Green 
 Ice Nine Investments, LLC 
 Emile Nuwaysir 
 Frank V. Sica 
 Skyline Venture
Partners Qualified Purchaser II, L.P. 
 Skyline Venture Partners II, L.P. 
 David Sneider 
 State of Wisconsin Investment Board 
 Tactics II LLC 
 Michael Treble 
 Venture Investors Early Stage Fund III Limited Partnership 
 Wisconsin Alumni Research Foundation 
 Stanley D. Rose 
 Rodney Wallace 
 Steven Smith 
 Dan Clutter 
  

 EXHIBIT B 
 OFFICER’S CERTIFICATE 
 The undersigned, being the Chairman of the Board of Directors of NimbleGen
Systems Inc., a Delaware corporation (the “Company”), does hereby certify to Godfrey & Kahn, S.C., for purposes of its opinion to be rendered to the purchasers (the “Purchasers”) pursuant to Section 6.1(g) and
Section 6.2(g) of that certain Subordinated Convertible Note and Warrant Purchase Agreement (the “Agreement”) dated as of the date hereof, by and between the Company and the Purchasers, as set forth below. Capitalized terms used, but
not otherwise defined, herein shall have the meanings assigned to such terms in the Agreement. 
 1. The Company is engaged in the business
of developing products and services related to DNA microarray technology. The Company does not own or lease any property in the United States of America outside of the State of Wisconsin. The Company does not have any employees in the United States
of America outside the State of Wisconsin. All contracts and purchase orders are subject to acceptance at the Company’s corporate office in Madison, Wisconsin. 
 2. There are no options, warrants, conversion privileges, preemptive rights or other rights outstanding to purchase any of the authorized but unissued capital stock or other securities of the Company, other than those
options and warrants set forth on the Schedule of Exceptions attached to the Agreement (the “Schedule of Exceptions”) and rights created in connection with the transactions contemplated by the Agreement, and except as provided in the
Standard Equity Agreement made September 27, 1999, between the Company and the Wisconsin Alumni Research Foundation, the Charter and the Stock Agreements. 
 3. All material agreements to which the Company is a party or by which it is bound are listed on the Schedule of Exceptions. There are no orders, writs, judgements, injunctions, decrees, determinations or awards which
have been entered against the Company. 
 4. There is no action, proceeding or investigation pending or threatened against the Company before
any court or administrative agency that questions the validity of the Agreement or might result, either individually or in the aggregate, in any material adverse change in the assets, financial condition, or results of operations of the Company.

 5. The Company has provided to Godfrey & Kahn, S.C. a true and complete copy of the minute book (which includes the Charter
and the By-Laws of the Company) and stock records of the Company. 
 6. The Company has not offered the Securities to any person or entity
other than the Purchasers (and its stockholders who have a right to elect to purchase the Securities under the Stockholders Agreement or the Charter). 
 7. The undersigned hereby acknowledges and agrees that Godfrey & Kahn, S.C. is relying upon this Certificate in providing its opinion. 
  

 IN WITNESS WHEREOF, the undersigned has executed this Officer’s Certificate as of
                    , 2004. 
  

			
	NIMBLEGEN SYSTEMS INC.
		
	By:	 	  

		 	Robert Palay, Chairman of the BoardAmended and Restated Loan and Security Agreement

 EXHIBIT 10.5 
 NOTE: The information designated by a bracketed asterisk [*] has been omitted pursuant to a request for confidential treatment and has been filed separately with the Securities and Exchange Commission.

 

 
 AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT 
 MADE BY AND AMONG 
 NIMBLEGEN
SYSTEMS, INC., 
 a Delaware corporation, 
 and certain of its direct and indirect subsidiaries, 
 as “BORROWER” 
 AND 
 GENERAL ELECTRIC CAPITAL
CORPORATION, 
 a Delaware corporation 
 as “LENDER” 
 December 29, 2006 

 TABLE OF CONTENTS 
  

			
	 	  	Page
	 ARTICLE I DEFINITIONS
	  	1
		
	     Section 1.1. General Definitions
	  	1
	     Section 1.2. Interpretation.
	  	14
		
	 ARTICLE II AMOUNT AND TERMS OF CREDIT
	  	15
		
	     Section 2.1. General Terms.
	  	15
	     Section 2.2. Revolving Facility.
	  	15
	     Section 2.3. Term Facility.
	  	18
	     Section 2.4. Loan Administration.
	  	20
	     Section 2.5. Payments Generally.
	  	20
	     Section 2.6. Use of Proceeds.
	  	20
	     Section 2.7. Capital Adequacy and Other Adjustments.
	  	20
	     Section 2.8. Tax Laws.
	  	21
	     Section 2.9. Interest Rate Limitation.
	  	21
	     Section 2.10. Term.
	  	21
	     Section 2.11. Collections and Lockbox Account.
	  	21
		
	 ARTICLE III CLOSING AND CONDITIONS OF LENDING
	  	23
		
	     Section 3.1. Conditions Precedent to Agreement.
	  	23
	     Section 3.2. Conditions Precedent to Advances.
	  	25
	     Section 3.3. Closing.
	  	25
		
	 ARTICLE IV REPRESENTATIONS AND WARRANTIES
	  	25
		
	     Section 4.1. Subsidiaries.
	  	25
	     Section 4.2. Organization and Good Standing.
	  	26
	     Section 4.3. Authority.
	  	26
	     Section 4.4. Binding Agreement.
	  	26
	     Section 4.5. Litigation.
	  	26
	     Section 4.6. No Conflicts.
	  	26
	     Section 4.7. Financial Condition.
	  	27
	     Section 4.8. No Default.
	  	27
	     Section 4.9. Title to Properties.
	  	27
	     Section 4.10. Taxes.
	  	27
	     Section 4.11. Securities and Banking Laws and Regulations.
	  	28
	     Section 4.12. ERISA.
	  	28
	     Section 4.13. Compliance with Laws.
	  	28
	     Section 4.14. Environmental Matters.
	  	29
	     Section 4.15. Intellectual Property.
	  	29
	     Section 4.16. Capitalization.
	  	30
	     Section 4.17. Material Facts.
	  	30
	     Section 4.18. Investments, Deposit Accounts, Guarantees, and Certain Contracts.
	  	30
	     Section 4.19. Business Interruption.
	  	30
	     Section 4.20. Joint Ventures.
	  	30
	     Section 4.21. Solvency.
	  	30
	     Section 4.22. Government Contracts.
	  	30
	     Section 4.23. OFAC.
	  	31
	     Section 4.24. Contracts.
	  	31
	     Section 4.25. No Broker.
	  	31
		
	 ARTICLE V AFFIRMATIVE COVENANTS
	  	31
		
	     Section 5.1. Financial Statements and Collateral Reports.
	  	31

  

 - i - 

			
	     Section 5.2. Existence, Good Standing, and Compliance with Laws.
	  	32
	     Section 5.3. Regulatory Matters.
	  	32
	     Section 5.4. Legality.
	  	33
	     Section 5.5. Taxes and Charges.
	  	33
	     Section 5.6. Insurance.
	  	33
	     Section 5.7. Information; Visits and Inspections; Searches.
	  	33
	     Section 5.8. Maintenance of Property.
	  	34
	     Section 5.9. Notification of Events of Default and Adverse Developments.
	  	34
	     Section 5.10. Employee Benefit Plans.
	  	34
	     Section 5.11. Collection of Accounts.
	  	34
	     Section 5.12. Places of Business.
	  	34
	     Section 5.13. Business Conducted.
	  	35
	     Section 5.14. Bank Accounts.
	  	35
	     Section 5.15. Termination/Default of Contracts.
	  	35
	     Section 5.16. Landlord Agreements, Mortgagee Agreements and Real Estate Purchases.
	  	35
	     Section 5.17. Financial Covenants.
	  	35
	     Section 5.18. Government Contracts.
	  	36
	     Section 5.19. Lien Documents; Collateral Generally.
	  	36
	     Section 5.20. Additional Collateral Provisions.
	  	37
	     Section 5.21. Compliance With Anti-Terrorism Orders.
	  	37
		
	 ARTICLE VI NEGATIVE COVENANTS
	  	38
		
	     Section 6.1. Indebtedness.
	  	38
	     Section 6.2. Joint Ventures.
	  	38
	     Section 6.3. No Liens and Encumbrances; No Disposition of the Collateral.
	  	39
	     Section 6.4. Restriction on Fundamental Changes.
	  	39
	     Section 6.5. Distributions and Management Fees.
	  	40
	     Section 6.6. Investments.
	  	40
	     Section 6.7. Subsidiaries.
	  	41
	     Section 6.8. Compliance with ERISA.
	  	41
	     Section 6.9. Licenses.
	  	41
	     Section 6.10. Transactions with Affiliates.
	  	41
	     Section 6.11. Use of Lender’s Name/Press Releases.
	  	41
	     Section 6.12. Contracts and Agreements/No Negative Pledge.
	  	41
	     Section 6.13. Margin Stock.
	  	41
	     Section 6.14. Truth of Statements and Certificates.
	  	41
	     Section 6.15. Capital Markets.
	  	41
		
	 ARTICLE VII SECURITY AGREEMENT; PROVISIONS RELATING TO ACCOUNTS COLLATERAL AND INVENTORY COLLATERAL
	  	42
		
	     Section 7.1. Grant of Security Interest.
	  	42
	     Section 7.2. Security Agreement.
	  	43
	     Section 7.3. Preservation of Security Interests.
	  	43
	     Section 7.4. Accounts Administration.
	  	44
		
	 ARTICLE VIII EVENTS OF DEFAULT
	  	44
		
	     Section 8.1. Events of Default.
	  	44
	     Section 8.2. Acceleration.
	  	47
	     Section 8.3. Remedies.
	  	47
	     Section 8.4. Nature of Remedies.
	  	48
	     Section 8.5. Waivers by Borrower.
	  	49
	     Section 8.6. Marshalling.
	  	49
		
	 ARTICLE IX MISCELLANEOUS
	  	49
		
	     Section 9.1. Expenses and Taxes.
	  	49
	     Section 9.2. My AccountSM.
	  	50

  

 - ii - 

			
	     Section 9.3. Judgment Currency.
	  	50
	     Section 9.4. Entire Agreement; Amendments.
	  	50
	     Section 9.5. No Waiver; Cumulative Rights.
	  	50
	     Section 9.6. Notices.
	  	50
	     Section 9.7. Severability.
	  	51
	     Section 9.8. Successors and Assigns.
	  	51
	     Section 9.9. Counterparts.
	  	51
	     Section 9.10. Survival of Terms.
	  	51
	     Section 9.11. Release of Lender.
	  	52
	     Section 9.12. Time.
	  	52
	     Section 9.13. Commissions.
	  	52
	     Section 9.14. Third Parties.
	  	52
	     Section 9.15. Discharge of Borrower’s Obligations.
	  	52
	     Section 9.16. Confidential Information.
	  	53
	     Section 9.17. Indemnity.
	  	53
	     Section 9.18. Appointment of Lender under this Agreement.
	  	53
	     Section 9.19. Lender Approvals.
	  	53
	     Section 9.20. Set-Offs.
	  	53
	     Section 9.21. Relationship.
	  	53
	     Section 9.22. Joint and Several Liability; Binding Obligations.
	  	54
	     Section 9.23. Choice of Law; Consent to Jurisdiction.
	  	54
	     Section 9.24. Waiver of Trial By Jury.
	  	54
	     Section 9.25. Existing Agreements Superseded; Exhibits and Schedules
	  	54

  

			
	Exhibits:	  	
		
	    Exhibit A	  	Financial Covenants and Conditions
	    Exhibit B	  	NimbleGen Projections
	    Exhibit C	  	Insurance Requirements
	    Exhibit D	  	Post-Closing Obligations
	    Exhibit E	  	Landlord’s Waiver and Consent
	    Exhibit F	  	Terms and Conditions of MyAccountSM Usage
	    Exhibit G	  	Payment Schedule
		
	Annexes	  	
		
	    Annex A	  	Information Certificate

  

 - iii - 

 AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT 
 THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (as it may be amended, restated, supplemented or otherwise modified from time to time,
together with all attachments, exhibits, schedules, riders and addenda, all of which are incorporated herein by this reference and made a part hereof, this “Agreement”), dated as of December 29, 2006, by and among NIMBLEGEN
SYSTEMS, INC., a Delaware corporation (“NimbleGen”) and NIMBLEGEN SYSTEMS OF ICELAND, LLC, a Delaware limited liability company (“NimbleGen Iceland”; and together with NimbleGen, individually and
collectively, “Borrower”), and GENERAL ELECTRIC CAPITAL CORPORATION, a Delaware corporation (together with its successors and assigns, collectively, “Lender”). 
 RECITALS 
 A. Borrower and
Lender entered into that certain Loan and Security Agreement, dated as of June 30, 2006, as amended by that certain Amendment and Waiver to Loan and Security Agreement, dated as of November 14, 2006, and that certain Amendment No. 2
and Consent to Loan and Security Agreement, dated as of December 8, 2006 (as so amended, the “Original Loan Agreement”), pursuant to which Lender agreed to provide certain financing arrangements and advance funds consisting of
advances (i) under a revolving line of credit (each a “Revolving Credit Loan”) in an aggregate amount not to exceed $4,000,000 and (ii) under a term facility (each a “Term A Loan”) in an aggregate amount
not to exceed $6,000,000, to Borrower on the terms and conditions set therein. 
 B. Borrower desires and Lender has agreed to make available
additional loans under two (2) term facilities, the first in an aggregate amount not to exceed $2,500,000 based on Borrower’s receipt of certain equity proceeds on December 22, 2006 in an amount equal to $12,500,000 (the “Term
B Loan”) and the second in an aggregate amount not to exceed $2,500,000 subject to the Borrower’s receipt of certain equity proceeds not later than March 31, 2007 an amount equal to $5,000,000 (the “Term C Loan”);
provided, however, in no event shall the aggregate outstanding balance of the Revolving Credit Loan, the Term A Loan, the Term B Loan and the Term C Loan exceed $11,000,000 (the “Maximum Facility Amount”). 

C. The parties desire to define the terms and conditions of the Term B Loan and the Term C Loan and amend and restate the terms of their existing
relationship and to reduce such agreements to writing. 
 NOW, THEREFORE, in consideration of the promises and covenants contained in
this Agreement, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties covenant and agree as follows: 
 ARTICLE I 
 DEFINITIONS 
 Section 1.1. General Definitions. As used in this Agreement, the following terms shall have the meanings set forth below:

 “Account” means collectively (a) any right to payment of a monetary obligation, whether or not earned by performance,
(b) without duplication, any “Account” or “Payment Intangible” (as such terms are defined in the Uniform Commercial Code), any accounts receivable (whether in the form of payments for services rendered or goods
sold, rents, license fees or otherwise) and all other rights to payment and/or reimbursement of every kind and description, whether or not earned by performance, (c) all rights, remedies, security interests, books and records, evidencing or
related to the Collateral (as defined below) and all rights under the Loan Documents in respect of the foregoing, (d) all information and data compiled or derived by Borrower or to which Borrower is entitled in respect of or related to the
foregoing, and (e) all proceeds of any of the foregoing. 
 “Account Debtor” means “Account Debtor”
(as that term is defined in the Uniform Commercial Code now or hereafter in effect), and any other Person obligated on any Account of Borrower. 

 “Affiliate” means, with respect to a specified Person, any Person directly or indirectly
controlling, controlled by, or under common control with the specified Person, including, without limitation, their equity holders and any Affiliates thereof. A Person shall be deemed to control a corporation or other entity if the Person
(a) owns or controls, directly or indirectly, twenty five percent (25%) or more of the Stock of such corporation or entity or (b) possesses or controls, directly or indirectly, the power to direct or cause the direction of the
management policies and business of the corporation or other entity, whether through the ownership of voting securities, by contract, or otherwise. Each Principal shall be deemed an Affiliate of each entity comprising Borrower regardless of whether
he or she meets the requirements in the previous two sentences. 
 “Agreement” has the meaning set forth in the Preamble.

 “Approved Goods or Services” means goods sold or services rendered by Borrower in the ordinary course of business, in
compliance with all Laws, and consistent with, related to or arising out of the type of goods sold or services rendered by Borrower through all or substantially all of its business operations as of the Closing Date. 
 “Approved Use of Proceeds” means working capital, capital expenditures and other corporate purposes not prohibited by this Agreement or
the other Loan Documents. 
 “Assignment of Claims Documents” means any notice, acknowledgement or other form, agreement or
consent required by the Federal Assignment of Claims Act, as amended (31 U.S.C. Section 3727, 41 U.S.C. Section 15) or any similar state or local law, and Subpart 32.8 of the Federal Acquisition Regulation, each in form and substance
satisfactory to Lender. 
 “Authorized Officer” means, with respect to any Person, the President, Chief Executive Officer,
Chief Financial Officer, Vice President or Treasurer of such Person. 
 “Base Rate” means a rate per annum equal to the
Prime Rate plus one percent (1.0%). 
 “Base Rate Loan” means any Revolving Credit Loan that bears interest at or by
reference to the Base Rate. 
 “Borrower” has the meaning set forth in the Preamble. 
 “Borrower Agent” means NimbleGen Systems, Inc. 
 “Borrower Contracts” means all contracts, agreements, instruments and other undertakings to which Borrower is a party or under which Borrower is obligated, including without limitation, all customer
agreements, service agreements, license agreements and distribution agreements. 
 “Borrowing Base” means, as of any date of
determination, an amount equal to eighty five percent (85%) of the Eligible Accounts. 
 “Borrowing Base Certificate”
has the meaning set forth in Section 2.2(d). 
 “Business Day” means any day except a Saturday, Sunday or other
day on which either the New York Stock Exchange is closed, or on which commercial banks in New York, New York are authorized by law to close. 
 “Cash” means money, currency or a credit balance in any Deposit Account. 
 “Cash Equivalents”
means, certificates of deposit or other financial instruments properly classified as “cash equivalents” in accordance with GAAP. 
 “CERCLA” has the meaning set forth in the definition of “Environmental Laws”. 
  

 2 

 “Change in Law” has the meaning set forth in Section 2.7. 
 “Change in Tax Law” has the meaning set forth in Section 2.8. 
 “Change of Control” means, with respect to any Person on or after the Closing Date, (a) that any Person or “group”
shall become the “beneficial owner” (as such terms are defined under Section 13d-3 of and Regulation 13D under the Securities Exchange Act of 1934) either directly or indirectly, of more than fifty percent (50%) of the
outstanding shares of Stock of such Person having the right to vote for the election of directors of such Person under ordinary circumstances, (b) that any change in the composition of its equity holders as of the Closing Date shall occur that
would result in any equity holder or group acquiring fifty percent (50%) or more of any class of Stock of such Person, (c) that any other Person (or group) shall acquire the power to elect a percentage of the board of directors giving such
other Person (or group) the power to direct the management or affairs of such Person, by obtaining proxies, entering into voting agreements or trusts, acquiring securities or otherwise, or (d) any Principal shall no longer be an officer or
director of NimbleGen or one or more of its wholly owned Subsidiaries and such Principal is not replaced with a Person approved by Lender in its reasonable discretion within 90 days of such Principal’s departure. Change of Control also means
the failure of NimbleGen to directly or indirectly own, free and clear of all Liens other than Liens in favor of Lender, 100% of the Stock of each of NimbleGen Iceland and NimbleGen Germany. 
 “Charges” has the meaning set forth in Section 5.5. 
 “Claims” has the meaning set forth in Section 9.11. 
 “Closing” has the meaning set forth in Section 3.3. 
 “Closing Date” means June 30, 2006. 
 “Collateral” has the meaning set forth in Section 7.1. 
 “Control” means, as such term is used with respect to any Person or entity, the possession, directly or indirectly, of the power to direct or cause the direction of the management policies and business of such Person or
entity, whether through the ownership of voting securities, by contract or otherwise, including the correlative meanings of the terms “controlling,” “controlled by” and “under common control with”.

 “Controlled Group” means all businesses that would be treated as a single employer with Borrower under
Section 4001(b) of ERISA. 
 “Credit Facility” or Credit Facilities have the meanings set forth in
Section 2.1. 
 “December 2006 Offering” has the meaning set forth in Section 3.1(p). 
 “Default” means any Event of Default or any fact, event, condition or circumstance that, with the passage of time or the giving of
notice or both, would become an Event of Default. 
 “Deposit Account” has the meaning set forth in
Section 2.11(a). 
 “Deposit Account Control Agreement” means an agreement, in form and substance satisfactory
to Lender, among Lender, Borrower and each bank in which Borrower maintains a Deposit Account. 
 “Depository Bank” has the
meaning set forth in Section 2.11(a). 
 “Domestic Subsidiary” means any direct or indirect Subsidiary of
NimbleGen formed under the laws of any state or territory of the United States. 
 “Eligible Account” has the meaning set
forth below; provided that Lender may change the criteria for Eligible Accounts as set forth below from time to time in its discretion consistent with its past lending practices. Any Accounts, which are not Eligible 

  

 3 

 
Accounts, shall nevertheless be part of the Collateral. Subject to the foregoing, “Eligible Account” means a the face amount of any Account
of Borrower generated in the ordinary course of such Borrower’s business from the rendition of Approved Goods or Services, generated originally in the name of Borrower and not acquired via assignment or otherwise, less, without duplication, any
and all returns, rebates, discounts (which may, at Lender’s option, be calculated on shortest terms), credits, allowances or excise taxes of any nature at any time issued, owing, claimed by Account Debtors, granted, outstanding or payable in
connection with such Account, and that Lender, in its discretion consistent with its past lending practices, deems to be an Eligible Account. Without limiting the generality of the foregoing, no Account shall be an Eligible Account if: 

(i) the Account remains unpaid more than ninety (90) days past the claim or invoice date, and, to the extent that such Account is derived from
the provision of services, not more than 105 days after such services are provided; 
 (ii) the Account is subject to any defense, set-off,
recoupment, counterclaim, deduction, discount, credit, chargeback, freight claim, allowance, or adjustment of any kind, or the applicable Borrower is not able to bring suit or otherwise enforce its remedies against the Account Debtor through
judicial process; 
 (iii) if the Account arises from the sale of goods, (A) the sale was not an absolute, bona fide sale, (B) the
sale was made on consignment or on approval or on a sale-or-return or bill-and-hold or progress billing basis, (C) the sale was made subject to any other repurchase or return agreement, (D) the goods have not been shipped to the Account
Debtor or its designee, (E) the sale was not made in compliance with applicable Laws, or (F) any part of any goods the sale of which has given rise to the Account has been returned, rejected, lost, or damaged (but only such portion of the
Account attributable to such returned, rejected, lost or damaged goods shall be ineligible); 
 (iv) if the Account arises from the
performance of services, (A) the services have not actually been performed, (B) the services were undertaken in violation of any Law, or (C) the Account represents a progress billing for which services have not been fully and
completely rendered; 
 (v) the Account is subject to a Lien other than a lien in favor of Lender; 
 (vi) the Account is evidenced by chattel paper or an instrument of any kind or has been reduced to judgment; 
 (vii) the Account Debtor is an Affiliate or Subsidiary of Borrower, or the Account Debtor holds any Indebtedness of Borrower; 
 (viii) twenty five percent (25%) or more of the aggregate unpaid Accounts from the Account Debtor are not deemed Eligible Accounts under this
Agreement; 
 (ix) the aggregate amount of Restricted Grant Funds exceeds ten percent (10%) of the net amount of all Eligible Accounts,
to the extent such excess exceeds ten percent (10%) of such net amount of Eligible Accounts; 
 (x) the total unpaid Accounts of the
Account Debtor exceed twenty percent (20%) of the net amount of all Accounts; 
 (xi) any covenant, representation or warranty
contained in the Loan Documents with respect to such Account has been breached in any material respect; 
 (xii) the Account has not been
invoiced to the Account Debtor in accordance with the procedures and requirements of the applicable Account Debtor; 
  

 4 

 (xiii) the Account is an obligation of an Account Debtor that is the Federal (or state or local)
government or a political subdivision thereof, unless Lender has agreed in writing that the Accounts of such Account Debtor shall qualify as an Eligible Account, and, in each case, Lender has received from the Account Debtor the related Assignment
of Claims Documents, fully acknowledged by the responsible contracting officer(s), or other acknowledgement of Lender’s notice of assignment of such obligation pursuant to this Agreement; 
 (xiv) the Account is an obligation of an Account Debtor that has suspended business, made a general assignment for the benefit of creditors, is unable
to pay its debts as they become due or as to which a petition has been filed (voluntary or involuntary) under any law relating to bankruptcy, insolvency, reorganization or relief of debtors, or the Account is an Account as to which any facts, events
or occurrences exist that could reasonably be expected to impair the validity, enforceability or collectibility of such Account or reduce the amount payable or delay payment thereunder; 
 (xv) the Account Debtor has its principal place of business or executive office outside the United States or the Account is payable in a currency other
than United States dollars; 
 (xvi) the Account Debtor is an individual; 
 (xvii) the Account does not arise from the sale of Approved Goods or Services; 
 (xviii) the Account includes late charges or finance charges (but only such portion of the Account shall be ineligible); or 
 (xix) the Account arises out of the sale of any inventory upon which any Person (other than Lender) holds, claims or asserts a Lien. 
 “Environmental Laws” means all Laws relating to the regulation and protection of human health, safety, the environment and natural
resources (including ambient air, surface water, groundwater, wetlands, land surface or subsurface strata, wildlife, aquatic species, vegetation and mold). Environmental Laws include the Comprehensive Environmental Response, Compensation, and
Liability Act of 1980 (42 U.S.C. §§ 9601 et seq.) (“CERCLA”); the Hazardous Material Transportation Act (49 U.S.C. §§ 1801 et seq.); the Federal Insecticide, Fungicide, and Rodenticide Act (7 U.S.C. §§
136 et seq.); the Resource Conservation and Recovery Act (42 U.S.C. §§ 6901 et seq.) (“RCRA”); the Toxic Substance Control Act (15 U.S.C. §§ 2601 et seq.); the Clean Air Act (42 U.S.C. §§ 740 et seq.);
the Federal Water Pollution Control Act (33 U.S.C. §§ 1251 et seq.); the Occupational Safety and Health Act (29 U.S.C. §§ 651 et seq.) (“OSHA”); and the Safe Drinking Water Act (42 U.S.C. §§ 300(f) et
seq.), and any and all regulations promulgated thereunder, and all analogous state and local counterparts or equivalents and any transfer of ownership notification or approval statutes. 
 “Environmental Liabilities” means all liabilities, obligations, responsibilities, remedial actions, removal costs, losses, damages,
punitive damages, consequential damages, treble damages, costs and expenses (including all reasonable fees, disbursements and expenses of counsel, experts and consultants and costs of investigation and feasibility studies), fines, penalties,
sanctions and interest incurred as a result of any claim, suit, action or demand by any Person, whether based in contract, tort, implied or express warranty, strict liability, criminal or civil statute or common law (including any thereof arising
under any Environmental Law, permit, order or agreement with any Governmental Authority) and that relate to any health or safety condition regulated under any Environmental Law, or in connection with any Release, threatened Release, or the presence
of a Hazardous Material. 
 “ERISA” has the meaning set forth in Section 4.12. 
 “Event of Default” and “Events of Default” have the meanings set forth in Section 8.1. 
 “Federal Food, Drug, and Cosmetic Act” means the Federal Food, Drug and Cosmetic Act, as amended, 42 U.S.C. §§ 201 et.
seq. 
  

 5 

 “FIRREA” means the Financial Institutions Reform, Recovery And Enforcement Act of 1989,
as amended from time to time. 
 “Fiscal Year” means each twelve-month period commencing on January 1 and ending on
December 31 during each year of the term of the Loan. 
 “GAAP” means generally accepted accounting principles applied
in a consistent manner. 
 “Government Contract” means any contract or agreement (including, but not limited to, any lease)
between Borrower and any Account Debtor that is subject to the Federal Assignment of Claims Act, as amended (31 U.S.C. Section 3727, 41 U.S.C. Section 15) or any similar state or local law. 
 “Governmental Approvals” means, collectively, all consents, licenses, and permits and all other authorizations or approvals required
from any Governmental Authority. 
 “Governmental Authority” means and includes any federal, state, District of Columbia,
county, municipal, or other governmental unit and any political subdivision, department, commission, board, bureau, agency or instrumentality thereof, whether domestic or foreign. 
 “Hazardous Material” means any substances defined or designated as hazardous or toxic waste, hazardous or toxic material, hazardous or
toxic substance, or similar term, by any Environmental Law or any Governmental Authority applicable to Borrower or its business, operations or assets. 
 “Highest Lawful Rate” means the maximum lawful rate of interest referred to in Section 2.9 that may accrue pursuant to this Agreement. 
 “HIPAA” means the Health Insurance Portability and Accountability Act of 1996, as the same may be amended, modified or supplemented from
time to time, and any successor statute thereto, and any and all rules or regulations promulgated from time to time thereunder. 
 “HIPAA Compliant” means that the applicable Person is in compliance in all material respects with each of the applicable requirements of the so-called “Administrative Simplification” provisions of HIPAA, and is
not and could not reasonably be expected to become the subject of any civil or criminal penalty, process, claim, action or proceeding, or any administrative or other regulatory review, survey, process or proceeding (other than routine surveys or
reviews conducted by any government health plan or other accreditation entity) that could result in any of the foregoing or that could reasonably be expected to materially adversely effect such Person in connection with any actual or potential
violation of the provisions of HIPAA by such person. 
 “Icelandic Accounts” has the meaning set forth in
Section 5.14. 
 “Indebtedness” of a Person means at any date, without duplication, (a) all obligations of
such Person for borrowed money, (b) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments, or upon which interest payments are customarily made, (c) any obligation of such Person with respect to
leases of property (real, personal or mixed) that is properly classified as a capital lease liability on a balance sheet in conformity with GAAP, (d) all obligations of such Person to pay the deferred purchase price of property or services
incurred in the ordinary course of business if the purchase price is due more than six (6) months from the date the obligation is incurred, (e) all Indebtedness secured by a Lien on any asset of such Person, whether or not such
Indebtedness is otherwise an obligation of such Person, (f) all guaranty, support or similar obligations of such Person in respect of any Indebtedness of any other Person (other than endorsements for collection or deposit in the ordinary course
of business), (g) all contingent or non-contingent obligations of such Person to reimburse any bank or other Person in respect of amounts paid under a letter of credit or similar instrument, (h) the principal balance outstanding under any
synthetic lease, tax retention operating lease, off-balance sheet loan or similar off-balance sheet financing product plus any accrued interest thereon, (i) all equity securities of such Person subject to repurchase or redemption otherwise than
at the sole option of such Person, (j) all “earnouts” and similar payment obligations of such Person, (k) all obligations of such Person to purchase securities (or other property) that arise out of or in 

  

 6 

 
connection with the issuance or sale of the same or substantially similar securities (or property), and (l) all obligations of such Person under any
foreign exchange contract, currency swap agreement, interest rate swap, cap or collar agreement or other similar agreement or arrangement designed to alter the risks of that Person arising from fluctuations in currency values or interest rates, in
each case whether contingent or matured. 
 “Indemnitee” has the meaning set forth in Section 9.17. 

“Information Certificate” means the Information Certificate attached hereto as Annex A. 
 “Intellectual Property” has the meaning set forth in Section 4.15. 
 “Intercompany Notes (Unsecured)” has the meaning set forth in Section 6.1(d). 
 “Intercompany Notes (Secured)” has the meaning set forth in Section 6.1(e). 
 “Intercompany Notes” has the meaning set forth in Section 6.1(e). 
 “Interest Period” means, with respect to each Revolving Credit Loan for which Borrower has selected a LIBOR Rate, one (1) month.

 “Internal Revenue Code” means the Internal Revenue Code of 1986, as amended. 
 “Investment” means (a) any direct or indirect purchase or other acquisition by Borrower of, or of a beneficial interest in, any of
the Stock of any other Person (other than any entity comprising Borrower); (b) any direct or indirect redemption, retirement, purchase or other acquisition for value, by Borrower from any Person (other than any entity comprising Borrower), of
any Stock of such Person; and (c) any direct or indirect loan, advance or capital contribution by Borrower to any other Person (other than any entity comprising Borrower), including all indebtedness and accounts receivable from that other
Person that are not current assets or did not arise from sales to that other Person in the ordinary course of business. The amount of any Investment shall be the original cost of such Investment plus the cost of all additions thereto, without any
adjustments for increases or decreases in value, or write-ups, write-downs or write-offs with respect to such Investment. 
 “JPMorgan” means JPMorgan Chase Bank, N.A. 
 “JPMorgan Collateral Account” has the meaning set
forth in Section 5.14(c). 
 “Judgment Currency” has the meaning set forth in Section 9.3(a).

 “Judgment Currency Conversion Date” has the meaning set forth in Section 9.3(a). 
 “Laws” means, collectively, all federal, state, District of Columbia, county, municipal, or other governmental unit, statutes, codes,
ordinances, treaties orders, rules and regulations, including judicial opinions or presidential authority in the applicable jurisdiction, now or hereafter in effect, and in each case as amended or supplemented from time to time, whether domestic or
foreign. 
 “Lender” has the meaning set forth in the Preamble. 
 “Lender Parties” has the meaning set forth in Section 9.11. 
 “Lender’s Concentration Account” has the meaning set forth in Section 2.11(d). 
 “LIBOR” means, for each Interest Period, a rate of interest per annum determined by Lender equal to (a) the offered rate for U.S.
dollar deposits on Telerate Page 3750 as of 11:00 a.m. London time (or such other pages as may replace the Telerate Page on that service for the purposes of displaying London interbank offered rates of major banks) divided by (b) a number
equal to 1.0 minus the aggregate (but without duplication) of the rates (expressed as a decimal fraction) of reserve requirements in effect on the day that 

  

 7 

 
is one (1) LIBOR Business Day prior to the beginning of such Interest Period (including basic, supplemental, marginal and emergency reserves under any
regulations of the Federal Reserve Board or other Governmental Authority having jurisdiction with respect thereto, as now and from time to time in effect) for Eurocurrency funding (currently referred to as “Eurocurrency Liabilities”
in Regulation D of the Federal Reserve Board) that are required to be maintained by a member bank of the Federal Reserve System. LIBOR for each Interest Period shall be fixed based upon LIBOR published prior to and in effect on the first
(1st) full LIBOR Business Day next preceding the first (1st) day of such Interest Period (unless such date is not a Business Day, in which event the next succeeding Business Day will be used). If such interest
rates shall cease to be available from Telerate News Service, the LIBOR Rate shall be determined from such substitute financial reporting service or source as Lender shall choose, in its reasonable discretion. 
 “LIBOR Business Day” means on a Business Day on which banks in the City of London are generally open for interbank or foreign exchange
transactions. 
 “LIBOR Loan” means any Revolving Credit Loan that bears interest at a rate determined by reference to the
LIBOR Rate. 
 “LIBOR Rate” means a rate per annum equal to LIBOR plus 3.50%. 
 “License” or “Licenses” means all licenses, certifications, registrations, product clearances or approvals, listings or
permits required by any Governmental Authority for the operation of Borrower’s business and commercial distribution of its products or for the ownership or operation of any Location. 
 “Lien” means any mortgage, pledge, hypothecation, assignment, deposit arrangement, encumbrance, lien (statutory or otherwise), charge or
other security interest or any preference, priority or other security agreement or preferential arrangement, of any kind or nature whatsoever (including, without limitation, any conditional sale or other title retention agreement, any deposit or
restriction on the sale or transfer of assets and any capital lease having substantially the same practical effect as any of the foregoing or any notice or claim against Accounts under a Government Contract). 
 “Loan” or “Loans” means, collectively, the Credit Facilities contemplated hereunder, and includes, without limitation,
the Credit Facilities defined in the Recitals as Loans. 
 “Loan Documents” means and includes this Agreement, the Notes,
the Information Certificate, and each and every other document now or hereafter delivered by Borrower in connection with this Agreement, as any of them may be amended, modified, increased, renewed or restated from time to time. 
 “Location” means any manufacturing or fabrication facility, laboratory, office or other building or facility at which Borrower or any of
its Subsidiaries maintains an office, owns, leases or holds any other interest in real property. 
 “Lockbox” has the
meaning set forth in Section 2.11(c). 
 “Lockbox Agreements” has the meaning set forth in
Section 2.11(c). 
 “Material Adverse Effect” means, with respect to any one or more event, acts, conditions or
occurrences of whatever nature, whether singly or in conjunction with any other event or events, act or acts, condition or conditions, occurrence or occurrences, whether or not related, which gives rise to a material adverse change in, or a material
adverse effect upon, any of (a) the condition (financial or otherwise), operations, business, prospects or properties of Borrower, taken individually or as a whole, (b) the rights and remedies of Lender under any Loan Document, or the
ability of Borrower, taken as a whole, to perform any of its obligations under any Loan Document, (c) the legality, validity or enforceability of any Loan Document, or (d) the existence, perfection or priority of any security interest
granted in any Loan Document or the value of any material Collateral. 
  

 8 

 “Material Borrower Contracts” means the agreements and contracts listed on the
Information Certificate. 
 “Material Lease” means any lease having an annual rent in excess of $200,000. 
 “Maturity Date (Original)” means the earlier of (i) the Stated Maturity Date and (ii) the date on which the Obligations
otherwise become due as a result of acceleration of the Obligations as provided for in this Agreement. 
 “Maturity Date (Term
B)” means the earlier of (i) the Stated Term B Maturity Date and (ii) the date on which the Obligations otherwise become due as a result of acceleration of the Obligations as provided for in this Agreement. 
 “Maturity Date (Term C)” means the earlier of (i) the Stated Term C Maturity Date and (ii) the date on which the Obligations
otherwise become due as a result of acceleration of the Obligations as provided for in this Agreement. 
 “Maximum Facility
Amount” has the meaning set forth in the Recitals. 
 “Maximum Revolving Facility Amount” means an amount equal to
FOUR MILLION AND NO/100 DOLLARS ($4,000,000.00). 
 “Maximum Term A Facility Amount” means an amount equal to SIX MILLION
AND NO/100 DOLLARS ($6,000,000.00). 
 “Maximum Term B Facility Amount” means an amount equal to TWO MILLION FIVE HUNDRED
AND NO/100 DOLLARS ($2,500,000.00). 
 “Maximum Term C Facility Amount” means an amount equal to TWO MILLION FIVE HUNDRED
AND NO/100 DOLLARS ($2,500,000.00). 
 “Mechanics Claims” has the meaning set forth in Section 5.5. 

“Medical Products Laws” has the meaning set forth in Section 5.3(a). 
 “NimbleGen” has the meaning set forth in the Preamble. 
 “NimbleGen Germany” means NimbleGen Systems, GmbH, a German limited liability company. 
 “NimbleGen Iceland” has the meaning set forth in the Preamble. 
 “Note” or
“Notes” means any promissory note or notes or other writing from time to time evidencing Borrower’s obligation to pay the Obligations, as any of them may be amended, modified, increased, renewed or restated from time to time,
and includes, without limitation, (a) that certain Revolving Note, dated June 30, 2006, by Borrower payable to the order of Lender in the principal amount of $4,000,000, (b) that certain Term Note, dated June 30, 2006, made by
Borrower payable to the order of Lender in the principal amount of $6,000,000, (c) that certain Term Note, dated the Restatement Date, made by Borrower payable to the order of Lender in the principal amount of $2,500,000 (evidencing the Term B
Loan), and (d) that certain Term Note, dated the Restatement Date, made by Borrower payable to the order of Lender in the principal amount of $2,500,000 (evidencing the Term C Loan). 
 “Obligation Currency” has the meaning set forth in Section 9.3(a). 
  

 9 

 “Obligations” means (a) the principal of, and interest on, the Notes and all other
sums, fees, charges and expenses and other amounts due or payable under, and all liabilities in connection with, this Agreement or the other Loan Documents (whether or not such amounts accrue after the filing of any petition in bankruptcy or after
the commencement of any insolvency, reorganization or similar proceeding, and whether or not a claim for post-filing or post-petition interest, fees or other such other amounts are allowed in any such proceeding), (b) all agreements, duties and
covenants with and obligations to Lender arising under, out of, or as a result of or in connection with the Loan Documents, (c) all amounts advanced by Lender to preserve, protect, defend, and enforce its rights under this Agreement and the
other Loan Documents or in the Collateral, and all expenses incurred by Lender in connection therewith, and (d) any and all other present and future indebtedness, liabilities and obligations of every kind and nature whatsoever of Borrower to
Lender howsoever created, arising or evidenced, whether direct or indirect, absolute, fixed or contingent, joint or several, liquidated or unliquidated, matured, disputed, undisputed, legal, equitable, secured, unsecured, both now and hereafter
existing, or due or to become due, whether as borrower, guarantor, surety, indemnitor, assignor, pledgor or otherwise, and in each case whether or not the right of payment in respect thereof is reduced to judgment or such claim is discharged, stayed
or otherwise affected by any proceeding referred to in Section 8.1. 
 “OFAC Lists” means, collectively, the
Specially Designated Nationals and Blocked Persons List maintained by the Office of Foreign Asset Control, Department of the Treasury pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists
or other restricted Persons maintained pursuant to any of the rules and regulations of Office of Foreign Asset Control, Department of the Treasury or pursuant to any other applicable Executive Orders. 
 “Original Loan Agreement” has the meaning set forth in the Recitals. 
 “OSHA” has the meaning set forth in the definition of “Environmental Laws”. 
 “Outstanding Warrant” has the meaning set forth in Section 1.1. 
 “Permits” has the meaning set forth in Section 5.2. 
 “Permitted Indebtedness” has the meaning set forth in Section 6.1(b). 
 “Permitted Investments” has the meaning set forth in Section 6.6. 
 “Permitted Liens” means the following: (a) Liens imposed by law for taxes or mechanic’s, workmen’s, materialmen’s or
other similar Liens arising in the ordinary course of business with respect to obligations that are not due, or that are being contested in compliance with Section 5.5 and for which Borrower maintains adequate reserves, but only to the
extent subordinate to Lender’s Liens upon the Collateral; (b) Liens and encumbrances in favor of Lender; (c) statutory Liens of landlords, banks, carriers, warehouse men or similar Liens imposed by law incurred in the ordinary course
of business for amounts not yet overdue; (d) Liens arising out of judgments or awards so long as such judgment or award shall not constitute an Event of Default under Section 8.1(j); (e) easements, rights-of-way and similar
title exceptions on real property imposed by law or arising in the ordinary course of business that do not secure any monetary obligations and do not materially detract from the value of the affected property or interfere with the use of such
property or with the ordinary course of business; and (f) deposits and pledges of cash (i) in connection with workers compensation, unemployment insurance and other types of social security, or (ii) to secure the performance of
tenders, bids, leases, government contracts (other than for the payment of money) or trade contracts (other than for the payment of money), in each case, to the extent that such deposits or pledges of cash arise or are incurred in the ordinary
course of business and secure obligations not past due. 
 “Person” means an individual, partnership, corporation, trust,
joint venture, joint stock company, limited liability company, association, unincorporated organization, Governmental Authority, or any other entity. 
 “Plan” has the meaning set forth in Section 4.12. 
  

 10 

 “Pledge Agreement” means that certain Ownership Pledge, Assignment and Security
Agreement, dated as of June 30, 2006, by NimbleGen in favor of Lender pursuant to which NimbleGen pledges to Lender 65% of the Stock of NimbleGen Germany and 100% of the Stock of NimbleGen Iceland, all as collateral to secure the Obligations.

 “Pledged Debt” means all Indebtedness owed to such Borrower, including, without limitation, all Indebtedness described in
the Information Certificate, issued by the obligors named therein, the instruments evidencing such Indebtedness, and all interest, cash, instruments and other property or proceeds from time to time received, receivable or otherwise distributed in
respect of or in exchange for any or all of such Indebtedness. 
 “Pledged Securities” has the meaning set forth in
Section 7.1(n). 
 “Prime Rate” means, for any day, the rate of interest that is identified as the
“Prime Rate” published from time to time by Citibank, NA, with the understanding that such rate may merely be a reference rate of Citibank, NA and may not necessarily represent the lowest or best rate actually charged to any of its
customers. If such rate ceases to be so published, then the Base Rate shall be quoted from such other generally available and recognizable source as Lender may select in its reasonable discretion. Any change in the Base Rate due to a change in such
Prime Rate shall be effective on the effective date of such change in such Prime Rate. 
 “Principal” means Stanley Rose,
Roland Green or David Snyder or any other Person, approved by Lender in its reasonable discretion, who is appointed to replace Stanley Rose, Roland Green or David Snyder. 
 “Proceeding” has the meaning set forth in Section 9.23. 
 “Prohibited
Transaction” means a “prohibited transaction” within the meaning of Section 406 of ERISA or Section 4975(c)(1) of the Internal Revenue Code that is not exempt under Section 407 or Section 408 of ERISA or
Section 4975(c)(2) or (d) of the Internal Revenue Code or under a class exemption granted by the U.S. Department of Labor. 
 “Public Health Service Act” means the Public Health Service Act, as amended, 42 U.S.C.§§ 201, seq. 
 “RCRA” has the meaning set forth in the definition of “Environmental Laws”. 
 “Release”
shall mean, as to any Person, any release, spill, emission, leaking, pumping, injection, deposit, disposal, discharge, dispersal, dumping, leaching or migration of Hazardous Materials in the indoor or outdoor environment by such Person, including
the movement of Hazardous Materials through or in the air, soil, surface water, ground water or property. 
 “Released
Parties” has the meaning set forth in Section 9.11. 
 “Releasing Party” has the meaning set forth in
Section 9.11. 
 “Reportable Event” means a “reportable event” as defined in
Section 4043(c) of ERISA for which the notice requirements of Section 4043(a) of ERISA are not waived. 
 “Reserves” means reserves established by Lender against the Borrowing Base from time to time with respect to known or anticipated liabilities, offsets, or liquidity needs of Borrower, including without limitation, Reserves
established to ensure the payment of accrued interest, fees, expenses and other liabilities. 
 “Restatement Date” means the
date on which all of the applicable conditions of Article III are satisfied or otherwise waived by Lender and the Loans shall be made available to Borrower under the Term B Facility. 
  

 11 

 “Restricted Grant Funds” means any direct or indirect grant, award or similar funding
from a university, institution, foundation or other entity that requires review and/or approval of invoices for expenses and charges related to such grant or award prior to payment of such invoice. 
 “Revolving Credit Loan” has the meaning set forth in the Recitals. 
 “Revolving Facility” has the meaning set forth in Section 2.2(a). 
 “Revolving Facility Commitment Fee” has the meaning set forth in Section 2.2(g). 
 “Revolving Facility Default Rate” means a rate per annum equal to two percent (2%) above the then applicable rate at which interest
accrues in respect of the Obligations under or relating to the Revolving Note prior to the occurrence of a Default or if no such rate is provided with respect to any Obligation under or relating to the Revolving Note, the Base Rate plus two
percent (2%) per annum. 
 “Revolving Note” has the meaning set forth in Section 2.2(a). 
 “Securities Account Control Agreement” means an agreement, in form and substance satisfactory to Lender, among Lender, Borrower and each
Securities Intermediary in which Borrower maintains a Securities Account. 
 “Securities Collateral” has the meaning set
forth in Section 7.1(n). 
 “Solvent” means, with respect to any Person on a particular date, that on such date
(a) the fair value of the property of such Person is greater than the total amount of liabilities, including contingent liabilities, of such Person; (b) the present fair salable value of the assets of such Person is not less than the
amount that will be required to pay the probable liability of such Person on its debts as they become absolute; (c) such Person does not intend to, and does not believe that it will, incur debts or liabilities beyond such Person’s ability
to pay as such debts and liabilities mature; and (d) such Person is not engaged in a business or transaction, and is not about to engage in a business or transaction, for which such Person’s property would constitute an unreasonably small
capital. The amount of contingent liabilities at any time shall be computed as the amount that, in light of all the facts and circumstances existing at the time, represents the amount that can be reasonably be expected to become an actual or matured
liability. 
 “Stated Maturity Date” means September 29, 2009. 
 “Stated Term B Maturity Date” means December 28, 2009. 
 “Stated Term C Maturity Date” means the day immediately preceding the third anniversary of the Term C Funding Date. 
 “Stock” means all certificated and uncertificated shares, options, warrants, general or limited partnership interests, limited liability
company interests, membership interests, participation or other equivalents (regardless of how designated) of or in a corporation, partnership, limited liability company or equivalent entity whether voting or nonvoting, including common stock,
preferred stock, or any other equity interest. 
 “Subsidiary” means, with respect to any Person, (a) any corporation
of which an aggregate of more than 50% of the outstanding Stock having ordinary voting power to elect a majority of the board of directors of such corporation is at the time, directly or indirectly, owned legally or beneficially by such Person
and/or one or more Subsidiaries of such Person, or with respect to which any such Person has the right to vote or designate the vote of 50% or more of such Stock whether by proxy, agreement, operation of law or otherwise, and (b) any
partnership or limited liability company in which such Person or one or more Subsidiaries of such Person has an equity interest (whether in the form of voting or participation in profits or capital contribution) of more than 50% or of which such
Person is a general partner. 
  

 12 

 “Sweep Event” means any of the following events: 
 (a) an Event of Default; 
 (b) any Borrower
shall have acted in a fraudulent manner or shall have committed an act of fraud; or 
 (c) availability under the Revolving Credit Facility
shall be less than 10% of the Borrowing Base, less reserves, as determined by Lender based on the most recent Borrowing Base Certificate delivered to Lender by Borrower, whether delivered under Section 2.2(d) or
Section 5.1(a). 
 “Term A Facility” has the meaning set forth in Section 2.3(a)(i). 
 “Term A Facility Commitment Fee” has the meaning set forth in Section 2.3(f). 
 “Term A Loan” has the meaning set forth in the Recitals. 
 “Term A Note” has the meaning set forth in Section 2.3(a)(i). 
 “Term A
Treasury Rate” means a rate per annum equal to the Treasury Index plus six and 73/100ths percent (6.73%). 
 “Term B/C
Facility Commitment Fee” has the meaning set forth in Section 2.3(f). 
 “Term B Facility” has the
meaning set forth in Section 2.3(b)(i). 
 “Term B Loan” has the meaning set forth in the Recitals. 

“Term B Note” has the meaning set forth in Section 2.3(b)(i). 
 “Term B Treasury Rate” means a rate per annum equal to the Treasury Index plus seven and 15/100ths percent (7.15%). 
 “Term C Facility” has the meaning set forth in Section 2.3(c)(i). 
 “Term C Funding Date” means the date on which all of the applicable conditions of Section 3.2 are satisfied or otherwise
waived by Lender and the Loans shall be made available to Borrower under the Term C Facility. 
 “Term C Loan” has the
meaning set forth in the Recitals. 
 “Term C Note” has the meaning set forth in Section 2.3(c)(i). 

“Term C Treasury Rate” means a rate per annum equal to the Treasury Index plus seven and 15/100ths percent (7.15%). 
 “Term Facility” means, collectively, the Term A Facility, Term B Facility and the Term C Facility. 
 “Term Facility Default Rate” means a rate per annum equal to two percent (2%) above the then applicable rate at which interest
accrues in respect of the Obligations under or relating to any Term Note prior to the occurrence of a Default or if no such rate is provided with respect to any Obligation under or relating to such Term Note, the Treasury Rate plus two percent (2%).

  

 13 

 “Term Loan” means any loan under the Term A Facility, the Term B Facility or the Term C
Facility. 
 “Treasury Index” means the three (3) year Treasury Constant Maturities Rate, as published by the United
States Federal Reserve in Statistical Release H.15(519) entitled “Selected Interest Rates” (i) on the Business Day two (2) days prior to the Closing Date, in the case of the initial funding made on the Closing Date, or
(ii) on the Business Day two (2) days preceding the date of any subsequent advance under the Term A Loan, in the case of an advance made after the Closing Date, as applicable. If any such date is not a Business Day, then the quote shall be
obtained on the Business Day immediately preceding such date. If the United States Treasury (a) quotes more than one such rate, then the highest of such quotes shall apply, or (b) ceases to quote such rate, then the Treasury Index shall be
determined from such substitute financial reporting service or source as Lender in its reasonable discretion shall determine. 
 “Uniform Commercial Code” or “UCC” means the Uniform Commercial Code as the same may, from to time, be in effect in the State of New York. 
 “Unused Line Fee” has the meaning set forth in Section 2.2(g). 
 “Warrant” means, collectively, that certain Warrant to Purchase 4,000 shares of Series E Preferred Stock and 66,000 shares of Series F
Preferred Stock, dated December 8, 2006 (the “Outstanding Warrant”), and that certain Warrant to Purchase 30,000 shares of Series F Preferred Stock, within 45 days of the Restatement Date, at an exercise price of $5.00 (subject to
adjustment as is provided therein), to be executed and delivered as set forth on Exhibit D, each executed by NimbleGen in favor of Lender. 
 Section 1.2. Interpretation. 
 (a) Accounting and UCC Terms. All accounting terms used in this Agreement
or the other Loan Documents shall have, unless otherwise specifically provided herein or therein, the meaning customarily given such term in accordance with GAAP, and all financial computations thereunder shall be computed, unless otherwise
specifically provided therein, in accordance with GAAP consistently applied. 
 Unless otherwise specified herein, the following terms have
the meanings ascribed to them in the UCC, provided, that if such term shall be defined differently in multiple divisions or articles of the UCC, the definitions for such terms specified in Article or Division 9 of the UCC shall control:
“Accounts”, “Account Debtor”, “Chattel Paper”, “Commercial Tort Claims”, “Contracts”, “Deposit Accounts”, “Documents”,
“Equipment”, “Financial Asset” “Fixtures”, “General Intangibles”, “Goods”, “Health-Care Insurance Receivable”,
“Instruments”, “Inventory”, “Investment Property”, “Letter-of-Credit Rights”, “Payment Intangible”, “Proceeds”, “Securities”,
“Securities Account”, “Securities Intermediary”, “Security Entitlement”, “Software” and “Supporting Obligations”. 
 (b) No provision of this Agreement or any other Loan Document shall be interpreted or construed against any party because that party or its legal
representative drafted that provision. The titles of the paragraphs of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. Any pronoun used in this Agreement shall be deemed to include
singular and plural and masculine, feminine and neuter gender as the case may be. The words “herein,” “hereof,” and “hereunder” and section, paragraph or clause references (not otherwise specified) shall be deemed to
refer to this entire Agreement, except as the context otherwise requires. Definitions contained in this Agreement that identify documents, including, but not limited to, the Loan Documents, shall be deemed to include all amendments and supplements
to such documents from the date hereof, and all future amendments, modifications, and supplements thereto entered into from time to time to satisfy the requirements of this Agreement or otherwise with the consent of Lender. Reference to this
Agreement contained in any of the foregoing documents shall be deemed to include all amendments and supplements to this Agreement. 
  

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 ARTICLE II 
 AMOUNT AND TERMS OF CREDIT 
 Section 2.1. General Terms. Subject to the
terms and conditions of this Agreement, from the Closing Date until the later of (i) the Maturity Date (Original), (ii) the Maturity Date (Term B), and (iii) the Maturity Date (Term C), Lender agrees to make available to Borrower the
credit facility or facilities hereinafter provided for (collectively, the “Credit Facilities” or individually a “Credit Facility”; if at any time there is only one credit facility provided for hereunder, then all
references herein to “Credit Facilities” shall be interpreted to refer to such sole credit facility). On the Closing Date and the Restatement Date, Borrower shall execute and deliver to Lender the applicable Notes evidencing
Borrower’s unconditional obligation to repay Lender for all advances and other extensions of credit made hereunder or in respect of the Credit Facilities, payable to the order of Lender in accordance with the terms in this Agreement and the
Notes. Each advance and other extension of credit hereunder shall be deemed evidenced by the Notes, which are deemed incorporated into and made a part of this Agreement by this reference. 
 Section 2.2. Revolving Facility. 
 (a) Revolving Loans; Interest Rate. Subject to the terms and conditions of this Agreement, Lender hereby agrees to make Revolving Credit Loans under a revolving line of credit (the “Revolving Facility”) in an amount
equal to the lesser of (i) the Borrowing Base less Reserves and (ii) the Maximum Revolving Facility Amount; provided, however, at no time shall the aggregate outstanding amount under the Term Facility plus the
aggregate outstanding amount under the Revolving Facility be greater than the Maximum Facility Amount; provided, further, Lender shall have no obligation to make any Revolving Credit Loan unless and until Borrower has fully
implemented, and Lender, in its discretion consistent with its past lending practices, has approved reports generated from, the Great Plains Accounts Receivable System or other similar system (which similar system shall be approved by Lender in its
discretion consistent with its past lending practices). Each Revolving Credit Loan shall bear interest at either the LIBOR Rate, in the case of any LIBOR Loan, or the Base Rate, in the case of a Base Rate Loan. Subject to the provisions hereof, all
or any portion of the Loans, at the option of the Borrower, may be converted into, a Base Rate Loan or a LIBOR Loan; provided, that the Borrower shall no longer have the option to have the Loans bear interest based on LIBOR, and any
outstanding LIBOR Loan shall be converted into a Base Rate Loan, if a Default shall have occurred and be continuing and the Lender shall have determined in its sole discretion to suspend Borrower’s LIBOR option. Any such conversion shall
include any interest due on the principal amount being converted and shall be subject to Section 2.2(i). 
 On the Closing Date,
Borrower shall execute and deliver to Lender one or more promissory notes, each evidencing Borrower’s unconditional obligation to repay Lender for the Revolving Credit Loans, advances and other extensions of credit made under the Revolving
Facility, in form and substance acceptable to Lender (as each may be amended, modified, increased, restated or replaced from time to time, collectively, the “Revolving Note”), each payable to the order of Lender in accordance with
the terms thereof. The Revolving Note shall bear interest on the outstanding principal balance of each Revolving Credit Loan from the date of such Revolving Credit Loan until repaid at a rate per annum (on the basis of the actual number of days
elapsed over a year of 360 days) equal to either the LIBOR Rate or the Base Rate, as specified by Borrower in the request for borrowing submitted pursuant to Section 2.2(d); provided, however, after the occurrence and
during the continuance of any Default such rate shall be equal to the Revolving Facility Default Rate. There shall be no more than five (5) Revolving Credit Loans outstanding at any one time. 
 (b) Nature of Revolving Facility. The Revolving Facility shall be in the nature of a revolving line of credit, and shall include sums advanced and
other credit extended by Lender to or for the benefit of Borrower from time to time under this Section 2.2, up to an amount that, in the aggregate, shall not exceed the Maximum Revolving Facility Amount depending upon the availability of
the Borrowing Base. The outstanding principal balance of the Revolving Facility may fluctuate from time to time, to be reduced by repayments made by Borrower (which may be made without penalty or premium), and to be increased by future Revolving
Credit Loans. All Revolving Credit Loans shall be due and payable in full upon the Maturity Date (Term C). Any determination made by Lender as to whether there is availability within the Borrowing Base for advances or extensions of credit is final
and binding upon Borrower absent manifest error. 
  

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 (c) Borrowing Base. The Borrowing Base shall be determined by Lender based on the most recent
Borrowing Base Certificate delivered to Lender by Borrower, whether delivered under Section 2.2(d) or Section 5.1(a), and such other information as may be available to Lender. Lender shall be entitled to rely on such
Borrowing Base Certificate and all other statements and representations made by Borrower with respect to any Account that Lender determines may be included in the Borrowing Base. Without limiting any other rights and remedies of Lender hereunder or
under the other Loan Documents, the Revolving Credit Loans shall be subject to Lender’s continuing right to implement Reserves against the Borrowing Base and to increase and decrease such Reserves from time to time, in Lender’s sole
discretion. Lender, in its sole discretion, may further adjust the Borrowing Base by applying percentages known as “liquidity factors” to Eligible Accounts by payor class based upon Borrower’s actual recent collection history
for each such payor class. Such liquidity factors may be adjusted by Lender from time to time in its sole discretion. Lender shall provide Borrower subsequent notice of the application or adjustment of Reserves and liquidity factors;
provided, however, failure to give such notice shall not affect Lender’s determination of the Borrowing Base. 
 (d)
Borrowing Request. A request for a Revolving Credit Loan or conversion or continuation of an existing Revolving Credit Loan shall be made, or shall be deemed to be made, in the following manner: Borrower shall give Lender written notice of
its intention to borrow, convert or continue, in which notice Borrower shall specify the amount of the proposed borrowing, or in the case of an existing Revolving Credit Loan, the amount to be converted or continued, in each case which amount shall
be not less than $100,000 (or a higher integral multiple of $50,000), whether such borrowing will be a Base Rate Loan or a LIBOR Loan and the proposed borrowing, conversion or continuation date, as the case may be, not later than 11:00 a.m. Eastern
time (i) two (2) Business Days prior to the proposed borrowing, conversion or continuation date in the case of any request for a LIBOR Loan or conversion or continuation of any Revolving Credit Loan or (ii) one (1) Business Day
prior to the proposed borrowing, conversion or continuation date in the case or any request for a Base Rate Loan; provided, however, that no such request may be made at a time when there exists any Default. The becoming due of any
amount required to be paid under this Agreement, whether as interest or for any other Obligation, shall be deemed irrevocably to be a request for a Revolving Credit Loan on the day following the due date in the amount required to pay such interest
or other Obligation if such amount was not paid by Borrower on the due date. If, upon the expiration of any Interest Period applicable to LIBOR Loans, Borrower has failed to timely select a new Interest Period to be applicable to such LIBOR Loans,
Borrower shall be deemed to have elected to continue such LIBOR Loans. 
 Borrower’s notice of its intention to borrow or continue any
existing Revolving Credit Loan shall be irrevocable and shall be accompanied with a certificate, on a form designated by Lender and in substance satisfactory to Lender, certifying the amount of the Borrowing Base and providing such backup
calculations and other information as Lender shall reasonably deem necessary (a “Borrowing Base Certificate”). Lender may change the form of such certificate from time to time and at all times shall have the right to request a
separate Borrowing Base Certificate from each entity comprising Borrower. After the making of the first Revolving Credit Loan, Borrower shall deliver a Borrowing Base Certificate to Lender no less often than monthly pursuant to
Section 5.1(a). 
 (e) Manner of Disbursement. Borrower hereby irrevocably authorizes Lender to disburse the proceeds of
each Revolving Credit Loan requested, or deemed to be requested, as follows: (i) the proceeds of each Revolving Credit Loan requested under Section 2.2(d) shall be disbursed by Lender by wire transfer to such bank account as
may be agreed upon by Borrower and Lender from time to time or elsewhere if pursuant to written direction from Borrower with consent of Lender; and (ii) the proceeds of each Revolving Credit Loan deemed to be requested under
Section 2.2(d) shall be disbursed by Lender by way of direct payment of the relevant interest or other Obligation. 
 (f)
Payment of Revolving Facility. Interest accrued on the Revolving Credit Loans shall be due and payable monthly in arrears on the first Business Day of each successive calendar month. Principal payable on account of Revolving Credit Loans
shall be due payable by Borrower to Lender on the Maturity Date (Term C); provided, however, that if the outstanding principal balance of the Revolving Credit Loans is, at any time, in excess of the Borrowing Base, Borrower shall
immediately repay such excess. Concurrently with the receipt by Borrower or Lender of any proceeds from insurance received pursuant to Section 5.6 or other indemnification payment (whether received out of escrowed funds or otherwise),
Borrower shall repay the then outstanding principal balance of the Revolving Credit Facility (without a corresponding reduction of the Maximum Revolving Facility Amount). 
  

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 Borrower may repay, in whole or in part, the then outstanding principal balance of the Revolving Loans
(without a corresponding reduction of the Maximum Revolving Facility Amount), without premium or penalty, upon written or telephonic notice (followed immediately by written confirmation thereof) to Lender not later than 11:00 a.m. New York time at
least one Business Day prior to each such prepayment. Any such prepayment of a LIBOR Loan on a day other than the last day of an Interest Period therefor shall include interest on the principal amount being repaid and shall be subject to
Section 2.2(i). All prepayments of a Loan shall be applied first to that portion of such Loan comprised of Base Rate Loans and then to that portion of such Loan comprised of LIBOR Loans, in direct order (starting with the first to
mature) of Interest Period maturities. 
 Borrower may voluntarily terminate the entire Revolving Facility upon at least thirty
(30) days prior written to Lender and payment in full of the principal balance of the Revolving Loans together with all interest due and payable on such amounts and all related costs fees and other expenses of Lender related thereto. Such
termination shall be subject to the penalties set forth in Section 2.2(h) and any prepayment of a LIBOR Loan on a day other than the last day of an Interest Period therefor shall also be subject to Section 2.2(i). 

(g) Revolving Facility Fees. As an inducement to Lender to make the Revolving Facility available to Borrower, Borrower hereby agrees to pay or
has paid to Lender the following fees: 
 (i) for so long as the Revolving Facility is available to Borrower, a monthly unused line fee (the
“Unused Line Fee”) equal to one half of one percent (0.50%) per annum multiplied by the average amount by which the Maximum Revolving Facility Amount exceeds the average amount of the outstanding principal balance of the Revolving
Credit Loans during the preceding month. The Unused Line Fee shall be due and payable monthly in arrears on the first Business Day of each successive calendar month and on the Maturity Date (Term C) (and to the extent the Maturity Date (Term C) does
not fall on the first Business Day of a calendar month, such fee shall be pro rated based on the number of days actually elapsed in such month) and shall be non-refundable when paid. 
 (ii) an initial commitment fee equal to one percent (1.00%) of the Maximum Revolving Facility Amount (the “Revolving Facility Commitment
Fee”), which Borrower has paid to Lender. The Revolving Facility Commitment Fee was deemed fully earned and non-refundable when paid. 
 (h) Revolving Facility Prepayment Penalty. In the event the Revolving Facility is terminated for any reason, Borrower shall pay to Lender an amount equal to the Maximum Revolving Facility Amount multiplied by (i) in the case of
any such termination prior to the first anniversary of the Closing Date, two percent (2%), or (ii) in the case of any such termination on or after the first anniversary of the Closing Date but prior to the second anniversary of the Closing
Date, one percent (1%), or (iii) in the case of any such termination on or after the second anniversary of the Closing Date but prior to 30 days before the Maturity Date (Term C), one-half of one percent (0.5%). 
 (i) Funding Losses. Borrower hereby agrees that it will indemnify Lender against any net loss or expense which Lender may sustain or incur
(including any net loss or expense incurred by reason of the liquidation or reemployment of deposits or other funds acquired by Lender to fund or maintain any LIBOR Loan), as reasonably determined by Lender, including but not limited to any funding
loss incurred as a result of (i) any payment, prepayment or conversion of any LIBOR Loan of Lender on a date other than the last day of an Interest Period for such Loan or (ii) any failure of Borrower to borrow or continue any Loan on a
date specified therefor in a notice of borrowing, conversion or continuation pursuant to this Agreement. For the purposes of this Section 2.2(i), all determinations shall be made as if Lender had actually funded and maintained each LIBOR
Loan during each Interest Period for such Loan through the purchase of deposits having a maturity corresponding to such Interest Period and bearing an interest rate equal to the LIBOR Rate for such Interest Period. 
  

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 Section 2.3. Term Facility. 
 (a) Term A Loan 
 (i) Term A Loan;
Interest Rate. Subject to the terms and conditions of this Agreement, Lender hereby agrees to make one or more term loans (the “Term A Facility”) to Borrower in the aggregate principal amount of the Maximum Term A Facility
Amount. On the Closing Date, Borrower shall execute and deliver to Lender one or more promissory notes, each evidencing Borrower’s unconditional obligation to repay Lender for the Term A Loans, in form and substance acceptable to Lender (as
each may be amended, modified, increased, restated or replaced from time to time, collectively, the “Term A Note”), each payable to the order of Lender in accordance with the terms thereof. The Term A Note shall bear interest on the
outstanding principal balance of each Term A Loan from the date of such Term A Loan until repaid at a rate per annum (on the basis of the actual number of days elapsed over a year of 360 days) equal to the Term A Treasury Rate; provided,
however, after the occurrence and during the continuance of a Default, other than a Default under only the Revolving Facility, such rate shall be equal to the Term Facility Default Rate. 
 (ii) Additional Term A Loan. Lender made an initial Term A Loan to Borrower in an amount equal to $5,000,000 on the Closing Date. On or about
September 29, 2006, Lender made one (1) additional Term A Loan in an amount equal to $1,000,000 based on Borrower’s achievement of the condition precedent that the actual revenue and EBITDA for the immediately preceding 12 calendar
months for which financial statements had been delivered was greater than or equal to eighty percent (80%) of the projected revenue and EBITDA for same 12 calendar month period as set forth in NimbleGen’s projections, dated
February 28, 2006, attached hereto as Exhibit B. 
 (b) Term B Loan 
 (i) Term B Loan; Interest Rate. Subject to the terms and conditions of this Agreement, Lender hereby agrees to make a term loan (the “Term
B Facility”) to Borrower in the aggregate principal amount of the Maximum Term B Facility Amount. On the Restatement Date, Borrower shall execute and deliver to Lender one or more promissory notes, each evidencing Borrower’s
unconditional obligation to repay Lender for the Term B Loans, in form and substance acceptable to Lender (as each may be amended, modified, increased, restated or replaced from time to time, collectively, the “Term B Note”), each
payable to the order of Lender in accordance with the terms thereof. The Term B Note shall bear interest on the outstanding principal balance of each Term B Loan from the date of such Term B Loan until repaid at a rate per annum (on the basis of the
actual number of days elapsed over a year of 360 days) equal to the Term B Treasury Rate; provided, however, after the occurrence and during the continuance of a Default, other than a Default under only the Revolving Facility, such
rate shall be equal to the Term Facility Default Rate. 
 (c) Term C Loan 
 (i) Term C Loan; Interest Rate. Subject to the terms and conditions of this Agreement, Lender hereby agrees to make a term loan (the “Term
C Facility”) to Borrower in the aggregate principal amount of the Maximum Term C Facility Amount. On the Restatement Date, Borrower shall execute and deliver to Lender one or more promissory notes, each evidencing Borrower’s
unconditional obligation to repay Lender for the Term C Loans, in form and substance acceptable to Lender (as each may be amended, modified, increased, restated or replaced from time to time, collectively, the “Term C Note”), each
payable to the order of Lender in accordance with the terms thereof. The Term C Note shall bear interest on the outstanding principal balance of each Term C Loan from the Term C Loan Funding Date until repaid at a rate per annum (on the basis of the
actual number of days elapsed over a year of 360 days) equal to the Term C Treasury Rate; provided, however, after the occurrence and during the continuance of a Default, other than a Default under only the Revolving Facility, such
rate shall be equal to the Term Facility Default Rate. 
 (d) Nature of the Term Facility. The Term Facility is not in the nature of a
revolving line of credit and, to the extent any Term Loan is paid for any reason, whether voluntarily or involuntarily, such amounts may not be reborrowed. In no event shall the aggregate amount of advances made (i) under the Term A Facility
exceed the Maximum Term A Facility Amount, (ii) under the Term B Facility exceed the Maximum Term B Facility Amount, (iii) under the Term C Facility exceed the Maximum Term C Facility Amount and (iii) under the Revolving Facility, the
Term A Facility, Term B Facility and the Term C Facility, exceed the Maximum Facility Amount. 
  

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 (e) Payment of Term Facility. Borrower shall pay: (i) commencing on the first Business Day of
the month immediately following the Closing Date, principal and interest on the Term A Loan as set forth on Exhibit G-1, attached hereto, continuing until the Stated Maturity Date or until all Obligations are satisfied in full (or sooner upon
the acceleration of the Obligations in accordance with the terms of this Agreement), (ii) commencing on the first Business Day of the month immediately following the advance of the additional Term A Loan pursuant to
Section 2.3(a)(ii), additional monthly principal and interest payments on such additional Term A Loan as set forth on Exhibit G-2, attached hereto, continuing until the Stated Maturity Date or until all Obligations are satisfied
in full (or sooner upon the acceleration of the Obligations in accordance with the terms of this Agreement), (iii) commencing on the first Business Day of the month immediately following the Restatement Date, principal and interest on the Term
B Loan as set forth on Exhibit G-3, attached hereto, continuing until the Stated Term B Maturity Date or until all Obligations are satisfied in full (or sooner upon the acceleration of the Obligations in accordance with the terms of this
Agreement), and (iv) commencing on the first Business Day of the month immediately following the Term C Funding Date, principal and interest on the Term C Loan as set forth on Exhibit G-4, attached hereto, continuing until the Stated
Term C Maturity Date or until all Obligations are satisfied in full (or sooner upon the acceleration of the Obligations in accordance with the terms of this Agreement). 
 (f) Term Facility Fees. As an inducement to Lender to make the Term A Loans, Borrower has paid to Lender a Commitment Fee equal to one percent (1.0%) of the Maximum Term A Facility Amount (the
“Term A Facility Commitment Fee”). Borrower agrees that Term A Facility Commitment Fee shall be applied first to a fully earned and non-refundable up-front fee in an amount equal to $30,000. The remaining portion of the Term
A Facility Commitment Fee shall be applied as follows, (i) $25,000 shall be applied to the first scheduled payment and (ii) the full remaining balance of the Term A Facility Commitment Fee shall be applied to Borrower’s first
scheduled payment following the advance of such additional Term A Loan pursuant to Section 2.3(a)(ii). 
 As an inducement to
Lender to make the Term B Loan and the Term C Loan, Borrower has paid to Lender a Commitment Fee equal to one percent (1.0%) of the sum of the Maximum Term B Facility Amount and the Maximum Term C Facility Amount (the “Term B/C Facility
Commitment Fee”). Borrower agrees that Term B/C Facility Commitment Fee shall be applied first to a fully earned and non-refundable up-front fee in an amount equal to $25,000. The remaining portion of the Term B/C Facility Commitment
Fee shall be applied as follows: in the event Borrower (A) on the Restatement Date (1) requests a Term B Loan pursuant to Section 2.3(b), then $12,500 of the Term B/C Facility Commitment Fee shall be applied to Borrower’s
first scheduled payment following the advance of such Term B Loan or (2) does not request a Term B Loan pursuant to Section 2.3(b), then such $12,500 of the balance of the Term B/C Facility Commitment Fee shall be retained by Lender
as a non-utilization fee, and (B) on the Term C Funding Date (1) requests a Term C Loan pursuant to Section 2.3(c), then $12,500 of the Term B/C Facility Commitment Fee shall be applied to Borrower’s first scheduled
payment following the Term C Funding Date or (2) does not request a Term C Loan pursuant to Section 2.3(c), then such $12,500 of the balance of the Term B/C Facility Commitment Fee shall be retained by Lender as a non-utilization
fee. 
 (g) Term Facility Prepayment Penalty. The Term Facility may be prepaid, in whole, but not in part, upon the payment of all
amounts outstanding under the Term Facility, including, but not limited to, the then-outstanding principal balance of the Term Facility, together with all fees, costs and expenses thereunder, plus an amount equal to the then-outstanding principal
balance of the Term Facility multiplied by (i) in the case of any such prepayment prior to the first anniversary of the Closing Date, five percent (5%), or (ii) in the case of any such prepayment on or after the first anniversary of the
Closing Date but prior to the second anniversary of the Closing Date, four percent (4%), or (iii) in the case of any such termination on or after the second anniversary of the Closing Date but prior to 30 days before the later to occur of
(i) the Maturity Date (Original), (ii) the Maturity Date (Term B) and (iii) the Maturity Date (Term C), three percent (3%). 
  

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 Section 2.4. Loan Administration. 
 (a) All advances and other extensions of credit to or for the benefit of Borrower shall constitute one general obligation of Borrower, and each entity
comprising Borrower, jointly and severally, will be obligated to pay all amounts owing under this Agreement. Such Obligations shall be secured by Lender’s Lien upon the Collateral. 
 (b) Lender shall enter all advances of proceeds under a Credit Facility as debits to a loan account in the name of Borrower and shall also record in said
loan account all payments made by Borrower on any Obligations that are indefeasibly paid to Lender, and may record therein, in accordance with customary accounting practice, other debits and credits, including interest and all charges and expenses
properly chargeable to Borrower. 
 (c) Lender will account to Borrower monthly with a statement of loans, charges and payments made pursuant
to this Agreement, and such accounting rendered by Lender shall be deemed final, binding and conclusive upon Borrower, absent manifest error, unless Lender is notified by Borrower in writing to the contrary within thirty (30) days of the date
each accounting is mailed to Borrower. Such notice shall be deemed an objection only to those items specifically objected to in the notice. 
 Section 2.5. Payments Generally. 
 (a) Borrower shall make all payments of principal, interest, fees,
reimbursements and all other payments required under this Agreement and under the Loans in immediately available US funds, as and when due, free and clear and without deduction for any and all taxes, levies, imposts, deductions, charges or
withholdings, and all liabilities with respect thereto of any nature whatsoever imposed by any taxing authority, excluding such taxes to the extent imposed on or measured by Lender’s net income, overall receipts or capital by the jurisdiction
in which Lender is organized or in which it maintains its applicable lending office. If Borrower shall be required by law to deduct any such amounts from or in respect of any sum payable hereunder to Lender, then the sum payable hereunder shall be
increased as may be necessary so that, after making all required deductions, Lender receives an amount equal to the sum it would have received had no such deductions been made. Except to the extent otherwise set forth in this Agreement, all payments
of principal of and interest on the Credit Facilities, all other charges and any other obligations of Borrower under this Agreement, shall be made to Lender to the Lender’s Concentration Account, in immediately available funds. All payments
shall be made without deduction for any set-off, recoupment, counterclaim or defense that Borrower now has or may have in the future. 
 (b)
Except for payments related to specific Obligations hereunder or as provided in the next sentence, all sums received by Lender under this Agreement shall be applied first to all unpaid fees, costs and expenses, second, to all accrued
and unpaid interest on the Term Loans, third, to all accrued and unpaid interest on the Revolving Credit Loans, fourth, to reduce the principal amount of the Term Loans in inverse order of their maturities and fifth, to reduce
the scheduled principal payments of the Revolving Credit Loans. Following any Default hereunder, or following the maturity of the Obligations, all sums received by Lender for the account of Borrower shall be applied to the Obligations in such order
as Lender shall elect in its discretion. 
 Section 2.6. Use of Proceeds. The proceeds of Lender’s advances under the
Loan shall be used solely for the Approved Use of Proceeds. 
 Section 2.7. Capital Adequacy and Other Adjustments. In the
event that Lender shall have determined that the adoption after the date hereof of any law, rule, regulation, guideline or order regarding capital adequacy, reserve requirements or similar requirements or compliance by Lender or any corporation
controlling Lender with any request or directive regarding capital adequacy, reserve requirements or similar requirements (whether or not having the force of law and whether or not failure to comply therewith would be unlawful) from any central bank
or governmental agency or body having jurisdiction (“Change in Law”) does or shall have the effect of reducing the rate of return on Lender’s or such corporation’s capital as a consequence of its obligations hereunder,
then Borrower shall from time to time within ten (10) days after notice and demand from Lender pay to Lender additional amounts necessary to compensate Lender for such reduction (which notice shall be accompanied by a statement setting forth
the basis for such claim and a calculation of the amount thereof in reasonable detail). 
  

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 Section 2.8. Tax Laws. 
 (a) Changes in Tax Laws. In the event that, subsequent to the initial advance under the Loan, (i) any changes in any existing law, regulation,
treaty or directive or in the interpretation or application thereof, (ii) any new law, regulation, treaty or directive enacted or any interpretation or application thereof, or (iii) compliance by Lender with any request or directive
(whether or not having the force of law) from any Governmental Authority, agency or instrumentality, does or shall (A) subject Lender to any tax of any kind whatsoever with respect to this Agreement or the other Loan Documents, or change the
basis of taxation of payments to Lender of principal, fees, interest or any other amount payable hereunder (except for net income taxes, or franchise taxes imposed in lieu of net income taxes, imposed generally by federal, state or local taxing
authorities with respect to interest or commitment fees or any other amounts payable hereunder or changes in the rate of tax on the overall net income, overall receipts or capital of Lender); or (B) impose on Lender any other condition or
increased cost in connection with the transactions contemplated hereby (a “Change in Tax Law”); and the result of any of the foregoing is to increase the cost to Lender of making or continuing the Loans hereunder, or to reduce any
amount receivable hereunder, then, in any such case, Borrower shall promptly pay to Lender, within ten (10) days after notice and demand from Lender, additional amounts necessary to compensate Lender, on an after-tax basis, for such additional
cost or reduced amount receivable, (which notice shall be accompanied by a statement setting forth the basis for such claim and a calculation of the amount thereof in reasonable detail). 
 (b) Withholding Forms. Upon any transfer of any interest in the Credit Facilities (or any change in status of Lender to be other than a
corporation), Lender shall execute and deliver to Borrower one or more (as Borrower may reasonably request) United States Internal Revenue Service Forms W-9, W-8ECI or W-8BEN or such other forms or documents, appropriately completed, as may be
applicable to establish that Lender is exempt from or subject to a reduced rate of withholding taxes. 
 Section 2.9. Interest
Rate Limitation. The parties intend to conform strictly to the applicable usury laws in effect from time to time during the term of the Credit Facilities. Accordingly, if any transaction contemplated by this Agreement would be usurious under
such laws, then notwithstanding any other provision of this Agreement: (a) the aggregate of all interest that is contracted for, charged, or received under this Agreement or under any other Loan Document shall not exceed the maximum amount of
interest allowed by applicable law (the “Highest Lawful Rate”), and any excess shall be promptly credited to Borrower by Lender (or, to the extent that such consideration shall have been paid, such excess shall be promptly refunded
to Borrower by Lender); (b) neither Borrower nor any other Person now or hereafter liable under this Agreement shall be obligated to pay the amount of such interest to the extent that it is in excess of the Highest Lawful Rate; and (c) the
effective rate of interest for the portion of the Credit Facilities that would otherwise be usurious under applicable laws shall be reduced to the Highest Lawful Rate. All sums paid, or agreed to be paid, to Lender shall, to the extent permitted by
applicable law, be allocated throughout the full term of the applicable Note until payment is made in full so that the actual rate of interest does not exceed the Highest Lawful Rate in effect at any particular time during the full term thereof. If
at any time the rate of interest under the applicable portion of the Credit Facilities exceeds the Highest Lawful Rate, the rate of interest to accrue pursuant to this Agreement under such portion of the Credit Facilities shall be limited,
notwithstanding anything to the contrary in this Agreement, to the Highest Lawful Rate, but any subsequent reductions in the applicable interest accrual rate shall not reduce the interest to accrue pursuant to this Agreement below the Highest Lawful
Rate until the total amount of interest accrued equals the amount of interest that would have accrued if the applicable Base Rate, LIBOR Rate, or Treasury Rate, as the case may be, had at all times been in effect. 
 Section 2.10. Term. Unless due and payable sooner pursuant to this Agreement, all principal, interest and other sums due under the
Loan Documents, and all other Obligations, shall be due and payable in full (i) with respect to the Term A Facility, on the Maturity Date (Original), (ii) with respect to the Term B Facility, on the Maturity Date (Term B), and
(iii) with respect to the Revolving Facility and the Term C Facility, on the Maturity Date (Term C). 
 Section 2.11.
Collections and Lockbox Account. 
 (a) Borrower shall establish and maintain, at their sole expense, depository accounts
(including any demand, time, savings, passbook, or similar account maintained with a bank) into which payments and collections of Accounts received by check, draft, 

  

 21 

 
electronic funds transfer or other similar means from any Account Debtor shall be immediately deposited or credited by Borrower, which shall be held in trust
by Borrower (for the benefit of Lender) (collectively, “Deposit Accounts” and the banks at which such Deposit Accounts are maintained, collectively, “Depository Banks”). Each such Deposit Account and Depository Bank
is set forth in the Information Certificate, which Borrower hereby represents constitutes the entire list of such Accounts and that each is in existence as of the Closing Date. Each Deposit Account shall be subject to a Deposit Account Control
Agreement, pursuant to which the Depository Bank shall, upon notice of any Sweep Event, transfer all funds on deposit in any such Deposit Account on each Business Day to Lender’s Concentration Account. Prior to the notice of any Sweep Event,
Borrower shall have full access to such Deposit Accounts and the funds therein. 
 (b) Borrower shall ensure that all payments and
collections of Accounts are either sent directly to a lockbox created pursuant to Section 2.11(c), below, or paid directly to a Deposit Account for deposit. 
 (c) Prior to the making of any Revolving Credit Loan, Borrower shall execute and deliver lockbox agreements, in form and substance satisfactory to Lender in its reasonable judgment (as they may be amended, restated,
modified or replaced from time to time in accordance with the terms hereof, collectively, the “Lockbox Agreements”) for each Deposit Account and new bank account opened pursuant to Section 5.14, which Lockbox Agreements
shall provide that upon notice of any Sweep Event, all items deposited in any associated lockbox (“Lockbox”) shall be deposited on each Business Day to the Lender’s Concentration Account. Such Lockbox Agreements may not be
modified without Lender’s prior written approval. Prior to the notice of any Sweep Event, Borrower shall have full access to the items received in such Lockbox. 
 (d) Following notice of the occurrence of a Sweep Event, all funds on deposit in any Deposit Account shall be sent by electronic funds transfer on a daily basis to a concentration account that Lender shall establish
and maintain, at the sole expense of Borrowers, which shall be: 
  

			
	Deutsche Bank Trust Company Americas
	 Address:
	 	 One Bankers Trust Plaza
 New York, New
York

	 ABA No.:
	 	021-001-033
	 Account No.:
	 	50-269-534
	 Account Name:
	 	GECC/Healthcare Receivables

 or to such other account that Lender may specify in writing to Borrower from time to time
(“Lender’s Concentration Account”). 
 (e) Notwithstanding anything in any Deposit Account Control Agreement or Lockbox
Agreement to the contrary, Borrower agrees that it shall be liable for any fees and charges in effect from time to time and charged by any Depository Bank or Lender in connection with this Agreement, any Deposit Account Control Agreement or any
Lockbox Agreement, and that Lender shall have no liability therefor. Borrower further acknowledges and agrees that, to the extent such fees and charges are not paid by Borrower, such fees and charges shall be deemed to be Revolving Credit Loans
hereunder and, to the extent that the payment of such fees or charges by Borrower as provided herein results in any over-advance, Borrower agrees to immediately repay to Lender, the amount of such over-advance. Borrower agrees to indemnify and hold
Lender harmless from any and all liabilities, claims, losses and demands whatsoever, including reasonable attorney’s fees and expenses, arising from or relating to actions of Borrower, Lender or Depository Bank pursuant to this
Section 2.11 or any Deposit Account Control Agreement or Lockbox Agreement. 
 (f) Following and during the continuance of any
Sweep Event, Lender shall apply, on a daily basis, all funds transferred into the Lender’s Concentration Account to reduce the outstanding Obligations, but for purposes of calculating interest shall be subject to a one (1) Business Day
clearance period. To the extent that any collections of Accounts or proceeds of other Collateral are not sent directly to a Lockbox but are received by Borrower, such collections shall be held in trust for the benefit of Lender and immediately
remitted, in the form received, to the Depository Bank for transfer to the Lender’s Concentration Account immediately upon receipt by Borrower. In any case where a bank fails to transfer funds notwithstanding Borrower’s instructions,
Borrower shall use their best efforts to immediately and completely cure such failure. 
  

 22 

 (g) Borrower (i) shall not establish, open or modify any Deposit Account or Lockbox without the
prior written consent of Lender, and (ii) shall not create, incur, assume or suffer to exist any Indebtedness whatsoever at any time from any Depository Bank. 
 ARTICLE III 
 CLOSING AND CONDITIONS OF LENDING 
 Section 3.1. Conditions Precedent to Agreement. The obligation of Lender to enter into and perform this Agreement and to make advances
under any Credit Facility on the Closing Date and the Restatement Date is subject to completion of the following conditions precedent, each to the satisfaction of Lender in its reasonable discretion: 
 (a) Lender shall have received fully executed copies or amendments or updates, as applicable, of the following documents, executed by Borrower and any
other required Persons: 
  

	 	(i)	this Agreement; 

  

	 	(ii)	the Information Certificate; 

  

	 	(iii)	the Notes; 

  

	 	(iv)	the Pledge Agreement and any other documents necessary or desirable for Lender to create and perfect its first priority security interest in the Collateral;

  

	 	(v)	the Warrant; 

  

	 	(vi)	the list of all assets located in Iceland, prepared in reasonable detail, together with all documents and deposit account balances necessary to create in favor of Lender “fixed
and floating charges” against all assets located in Iceland, including, but not limited to cash balances in the Icelandic Accounts sufficient to allow Lender to perfect its security interest in such Icelandic Accounts in an amount of not less
than $400,000; 

  

	 	(vii)	the Intercompany Notes and any related intercompany subordination agreement; 

  

	 	(viii)	UCC financing statements in the correct form for filing in each respective filing office; 

  

	 	(ix)	IRS form 8821 for each Domestic Borrower; and 

  

	 	(x)	such other agreements and documents as Lender may reasonably require 

 (b) Lender shall have received all searches required by Section 5.7. 
 (c) A certificate of an
Authorized Officer stating that (i) no Default shall have occurred and be continuing, (ii) that Borrower shall have complied and shall then be in compliance with all the terms, covenants and conditions of this Agreement and the other Loan
Documents, (iii) that the representations and warranties contained in Article IV shall be true and correct and (iv) the names and providing specimen signatures of the officers of Borrower authorized to execute documents on its behalf in
connection with the Loan. 
 (d) Lender shall have received copies of all board of directors resolutions of each entity comprising Borrower,
authorizing the execution, delivery and performance of the Loan Documents and the borrowing of the Loans and the granting of security interests under this Agreement and the other Loan Documents and such other approvals, authorizations and consents
as Lender may reasonably require. 
  

 23 

 (e) Lender shall have received (i) a copy, certified by the applicable state of organization of each
entity comprising Borrower of the certificate of incorporation, certificate of formation or certificate of limited liability partnership of each entity comprising Borrower, with any amendments to any of the foregoing, (ii) copies, certified as
true, correct and complete by an Authorized Officer, member or partner of each entity comprising Borrower, of all other documents, including bylaws, limited liability company agreements or operating agreements, necessary for performance of the
obligations of Borrower under this Agreement and the other Loan Documents, and (iii) certificates of good standing for each entity comprising Borrower issued by the state of organization of each such entity and by each state in which each such
entity is doing business except where the failure to be so qualified could not reasonably be expected to have a Material Adverse Effect. 
 (f) Lender shall have received a written opinions of counsel for Borrower, including, without limitation, counsel authorized to practice under the laws of Iceland, dated the date of this Agreement, in form and substance satisfactory to
Lender. 
 (g) Lender shall have received such financial statements, reports, certifications, and other operational information required to
be delivered under this Agreement. 
 (h) Lender shall have received payment of all fees and expenses, including all commitment fees,
provided for herein. 
 (i) Lender shall have received a Landlord’s Waiver and Consent, in form and substance substantially similar to
the Landlord’s Waiver and Consent, attached hereto as Exhibit E, from Borrower’s landlord with respect to the premises locate at One Science Court, Madison, Wisconsin. 
 (j) Evidence in form and substance satisfactory to Lender that (i) all of the obligations of Borrower to any prior lender (other than lenders of
Indebtedness permitted pursuant to Section 6.1), including without limitation, the Wisconsin Department of Commerce, have been performed and paid in full, or will be performed and paid in full from the proceeds of the initial advances
under the Credit Facilities on the Closing Date, and (ii) all Liens of any such prior lender on any property of Borrower in respect thereof have been or will be terminated immediately upon such payment. 
 (k) Lender shall have received evidence satisfactory to it that the insurance policies required under Section 5.6 are in full force and
effect, together with written evidence showing loss payable or additional insured clauses and the associated endorsements in favor of Lender as required under such Section 5.6. 
 (l) Lender shall have received a certificate of Borrower’s chief financial officer, dated the Closing Date, certifying that all of the conditions
specified in this Section 3.1 have been fulfilled, that there shall not have been any event, act, condition or occurrence which would be reasonably likely to result in a Material Adverse Effect since the December 31, 2004 financial
statement delivered by Borrower to Lender, and that both before and after giving effect to the transactions contemplated by the Loan Documents, each entity comprising Borrower is Solvent. 
 (m) Lender shall have received fully executed Deposit Account Control Agreements from each Depository Bank with respect to each Deposit Account held by
such Depository Bank and fully executed Securities Account Control Agreements from each Securities Intermediary with respect to each Securities Account held by such Securities Intermediary. 
 (n) Lender shall have received and is satisfied with each Material Borrower Contract. 
 (o) Such other documents and materials as Lender shall reasonably deem necessary or appropriate. 
 (p) Borrower shall have raised at least $12,500,000 through the issuance of Stock of NimbleGen pursuant to the transactions contemplated in that certain
Term Sheet for Series F Preferred Stock Financing of NimbleGen Systems, Inc., dated December 4, 2006 (the “December 2006 Offering”). 
  

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 Section 3.2. Conditions Precedent to Advances. Notwithstanding any other provision of
this Agreement, the obligation of Lender to make advances or other extensions of credit under the Credit Facilities on or after the Closing Date, including, without limitation, the additional Term A Loan made pursuant to Section 2.3(a)(ii) and
the Term C Loan made pursuant to Section 2.3(c), shall be subject to the completion of the following conditions precedent, each to the satisfaction of Lender in its sole discretion: 
 (a) The representations and warranties on the part of Borrower contained in Article IV shall be true and correct in all material respects at and as of the
date of disbursement or advance, as though made on and as of such date (except to the extent that such representations and warranties expressly relate solely to an earlier date and except that the references in Section 4.7 to financial
statements shall be deemed to be a reference to the then most recent annual and interim financial statements of Borrower furnished to Lender pursuant to Section 5.1); 
 (b) No Default shall have occurred and be continuing or would result from the making of the disbursement or advance; provided, however, the
condition precedent set forth in this clause (b) with respect to any Default that shall have occurred and be continuing under Section 5.17 shall apply only upon Borrower’s request for advances under the Revolving Credit
Facility; 
 (c) No event has occurred that has caused, or would be reasonably likely to result in a, Material Adverse Effect since the date
of this Agreement; 
 (d) Borrower has delivered to Lender a Borrowing Base Certificate in accordance with Section 2.2(d) with
respect to Revolving Credit Loans; 
 (e) Borrower shall have complied with the requirements of Section 2.11(c); and 

(f) Borrower shall have raised at least $5,000,000 through the issuance of Stock of NimbleGen for cash consideration to one or more existing or new
investors. 
 (g) Borrower shall have completed item (c) of Exhibit D hereto regarding the delivery of certain additional material
agreements, notes, consulting agreements and other documents. 
 The request and acceptance by Borrower of the proceeds of any advance in
respect of the Credit Facilities shall be deemed to constitute, as of the date of such request and as of the date of such acceptance, (i) a representation and warranty by Borrower that all of the conditions in this Section 3.2 have
been satisfied and (ii) a restatement by Borrower that the representations and warranties made by it in any Loan Document are true and correct in all material respects (except to the extent that such representations and warranties expressly
related solely to an earlier date and except that the references in Section 4.7 to financial statements shall be deemed to be a reference to the then most recent and annual and interim financial statements of Borrower furnished to Lender
pursuant to Section 5.1) and a reaffirmation by Borrower of the granting and continuance of Lender’s Liens in the Collateral under the Loan Documents. 
 Section 3.3. Closing. Closing shall occur at such time as may be mutually agreeable to the parties upon the execution of this Agreement and upon the satisfaction or waiver of all conditions by
Lender of this Article III and at such place as may be requested by Lender (the “Closing”). 
 ARTICLE IV 

REPRESENTATIONS AND WARRANTIES 
 Each entity comprising Borrower, jointly and severally, represents and warrants to Lender, and shall be deemed to, jointly and severally, represent and warrant on each day on which any advance, waiver, consent or amendment in respect of a
Credit Facility is requested or made (and each of the following representations and warranties shall survive the execution and delivery of this Agreement), that: 
 Section 4.1. Subsidiaries. Except as set forth in the Information Certificate, Borrower has no Subsidiaries. 
  

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 Section 4.2. Organization and Good Standing. (a) Borrower is a corporation, limited
liability company or limited liability partnership, as the case may be, (i) duly organized, validly existing, and in good standing under the Laws of its state of formation, (ii) is in good standing as a foreign corporation, limited
liability company or limited liability partnership, as the case may be, in each jurisdiction in which the character of the properties owned or leased by it therein or the nature of its business makes such qualification necessary and where the
failure to be so qualified could not reasonably be expected to cause a Material Adverse Effect, and (iii) has obtained all certificates, licenses and qualifications required under all Laws or orders of public authorities necessary for the
ownership and operation of all of its properties and transaction of all of its business except where the failure to obtain the same could not reasonably be expected to have a Material Adverse Effect, all of which are in the name of Borrower.

 (b) Borrower is a registered organization organized solely under the law of the state of its organization. Borrower’s jurisdiction of
organization and organizational identification number (if any) are listed on the Information Certificate and its exact legal name (as set forth on the public record of such jurisdiction of organization that shows Borrower to have been
organized) is as set forth in the Information Certificate and the signature blocks to this Agreement. 
 (c) Within five years before the
date of this Agreement, Borrower has not conducted business under or used any other name (whether corporate, partnership or assumed) other than as shown on the Information Certificate. Borrower is the sole owner of all names listed on the
Information Certificate and any and all business done and invoices issued in such names are Borrower’s sales, business, and invoices. Each trade name of Borrower represents a division or trading style of Borrower and not a separate Person or
independent Affiliate. 
 Section 4.3. Authority. Borrower has full corporate, limited liability company or limited
liability partnership, as the case may be, power and authority to enter into, execute, and deliver this Agreement and to perform its obligations under this Agreement, to borrow under the Credit Facilities, to execute and deliver the Note, and to
incur and perform the obligations provided for in the Loan Documents, all of which have been duly authorized by all necessary corporate, limited liability company or limited liability partnership (as the case may be) action. No consent or approval
of shareholders, members or partners of, or lenders to, Borrower and no consent, approval, filing or registration with any Governmental Authority is required as a condition to the validity of the Loan Documents or the performance by Borrower of its
obligations under the Loan Documents, which has not been obtained. 
 Section 4.4. Binding Agreement. This Agreement and
all other Loan Documents constitute, and the Note, when issued and delivered pursuant to this Agreement for value received, will constitute, the valid and legally binding obligations of Borrower, enforceable against Borrower in accordance with their
respective terms. 
 Section 4.5. Litigation. Except as disclosed in the Information Certificate, there are no actions,
suits, proceedings or investigations pending or threatened against Borrower or any of its Subsidiaries before any court or arbitrator or before or by any Governmental Authority (a) with respect to any of the Loan Documents or any of the
transactions contemplated thereby or (b) that, in any one case or in the aggregate, if determined adversely to the interests of Borrower or its Subsidiaries, would be reasonably likely to result in a Material Adverse Effect. Neither Borrower
nor any of its Subsidiaries is in default with respect to any order of any court, arbitrator, or Governmental Authority applicable to Borrower or such Subsidiary or its properties. 
 Section 4.6. No Conflicts. The execution and delivery by Borrower of this Agreement and the other Loan Documents do not, and the
performance of its obligations under the Loan Documents will not, violate, conflict with, constitute a default under, or result in the creation of a Lien or encumbrance upon the property of Borrower or any of its Subsidiaries (other than for the
benefit of Lender) under: (a) any provision of any articles of incorporation or bylaws, certificate of formation or operating agreement, or certificate of limited liability partnership or agreement of limited liability partnership, as the case
may be, of Borrower or any of its Subsidiaries, (b) any provision of any law, rule, or regulation applicable to Borrower or any of its Subsidiaries, (c) any indenture or other agreement or instrument to which Borrower or any of its
Subsidiaries is a party or by which it or its property is bound and, 

  

 26 

 
except to the extent Borrower or any of its Subsidiaries is deemed or found to be in breach of a provision in any such agreement or instrument, no such
agreement or instrument prohibits assignment of such agreement or instrument without the consent of the other party thereto by virtue of the grant of the security interest in Section 7.1, or (d) any judgment, order or decree of any
court, arbitration tribunal, or Governmental Authority having jurisdiction over Borrower or any of its Subsidiaries that is applicable to Borrower or any of its Subsidiaries. 
 Section 4.7. Financial Condition. The financial statements of Borrower that have been delivered to Lender fairly present the financial
condition of Borrower and the results of its operations and changes in financial condition as of the dates and for the periods referred to, and have been prepared in accordance with GAAP. There are no material unrealized or anticipated liabilities,
direct or indirect, fixed or contingent, of Borrower as of the dates of such financial statements that are not reflected in such financial statements or in the notes to such financial statements. There has been no event that would be reasonably
likely to result in or has caused, a Material Adverse Effect since the date of the last financial statement delivered to Lender. Borrower hereby represents and warrants that the federal tax identification number and Fiscal Year of each entity
comprising Borrower is as described on the Information Certificate. 
 Section 4.8. No Default. Neither Borrower nor any
of its Subsidiaries is in default under or with respect to any obligation in any respect that would be reasonably likely to result in a Material Adverse Effect. No Default or Event of Default has occurred and is continuing. 
 Section 4.9. Title to Properties. 
 (a) Title. Borrower has good title to (or valid leasehold interests in) all its real and personal property, except for minor defects in title that do not (i) affect the value or access to such property or
(ii) interfere with (A) its ability to conduct its business as currently conducted, (B) its ability to utilize such properties for their intended purposes, or (C) its right and power to transfer such property, subject to no Lien,
other than Permitted Liens. Neither Borrower nor any of its Subsidiaries has agreed or consented to cause any of its properties or assets whether owned now or hereafter acquired to be subject in the future (upon the happening of a contingency or
otherwise) to any Lien, mortgage, pledge, encumbrance or charge of any kind other than Permitted Liens. All of the Collateral, and all other property and assets of Borrower that are necessary to the conduct of Borrower’s business, is owned by
Borrower or the rights to same are held by Borrower in its name, and none of the Collateral, or any such property or assets are owned or the rights thereto held in the name of any other entity. 
 (b) Premises. The real estate listed on the Information Certificate constitutes all of the real property owned, leased or used by Borrower in its
business and Borrower will not execute any material agreement or contract in respect to such real estate after the date of this Agreement without giving Lender prompt written notice thereof. 
 (c) Places of Business. As of the Closing Date, the only places of business of Borrower, and the places where it keeps and intends to keep all
Collateral and records concerning the Collateral, are at the addresses set forth in the Information Certificate. The Information Certificate also lists the owner of record of each such property. Borrower’s Chief Executive Office is located in
the state and at the address shown in the Information Certificate. No Collateral is held by any bailee or warehouseman for which such bailee or warehouseman has issued a negotiable document (as defined in Section 7-104 of the UCC). 

Section 4.10. Taxes. Borrower and each of its Subsidiaries has filed, or has obtained extensions for the filing of, all federal,
state and other tax returns that are required to be filed, and has paid all taxes shown as due on those returns and all assessments, fees and other amounts due as of the date of this Agreement. All tax liabilities of Borrower and each of its
Subsidiaries are adequately provided for on the books of Borrower or such Subsidiary. No tax liability has been asserted by the Internal Revenue Service or other taxing authority against Borrower or any of its Subsidiaries for taxes in excess of
those already paid. 
  

 27 

 Section 4.11. Securities and Banking Laws and Regulations. 
 (a) The use of the proceeds of the Loan and issuance of the Note will not directly or indirectly violate or result in a violation of the Securities Act of
1933 or the Securities Exchange Act of 1934, as amended, or any regulations issued pursuant thereto, including, without limitation, Regulations U, T or X of the Board of Governors of the Federal Reserve System. Neither Borrower nor any of its
Subsidiaries is engaged in the business of extending credit for the purpose of the purchasing or carrying “margin stock” within the meaning of those regulations. No part of the proceeds of the Loan under this Agreement will be used to
purchase or carry any margin stock or to extend credit to others for such purpose. 
 (b) Borrower is not an investment company within the
meaning of the Investment Company Act of 1940, as amended, nor is it, directly or indirectly, controlled by or acting on behalf of any Person that is an investment company within the meaning of that Act. 
 Section 4.12. ERISA. Except as could not reasonably be expected to have a Material Adverse Effect, (a) no employee benefit
plan (a “Plan”) subject to the Employee Retirement Income Security Act of 1974 and the rules and regulations issued pursuant thereto, as each may be amended from time to time (collectively, “ERISA”) that is
maintained by Borrower or under which Borrower could have any liability under ERISA (i) has failed to meet minimum funding standards established in Section 302 of ERISA, (ii) has failed to substantially comply with all applicable
requirements of ERISA and of the Internal Revenue Code, including all applicable rulings and regulations thereunder, or (iii) has engaged in or been involved in a Prohibited Transaction, (b) neither Borrower nor any member of a Controlled
Group that includes Borrower has assumed, or received notice of a claim asserted against Borrower or another member of the Controlled Group for, withdrawal liability (as defined in the Multi-Employer Pension Plan Amendments Act of 1980, as amended)
with respect to any multi-employer pension plan, and (c) Borrower has timely made when due all contributions with respect to any multi-employer pension plan in which it participates and no event has occurred triggering a material claim against
Borrower for withdrawal liability with respect to any multi-employer pension plan in which Borrower participates. 
 Section 4.13.
Compliance with Laws. All of Governmental Approvals required by any Governmental Authority as of the Closing Date for the operation of the business and the commercial distribution of the products or for the ownership or operation of any
Location of Borrower and each of its Subsidiaries are listed on the Information Certificate. 
 (a) Except as described in the Information
Certificate, neither Borrower nor any of its Subsidiaries is in material violation of any Laws (including, without limitation, Medical Products Laws or any statute, rule or regulation relating to employment practices or to environmental,
occupational and health standards and controls); 
 (b) Borrower and each of its Subsidiaries has obtained all Governmental Approvals
necessary for the ownership of its properties and the conduct of its business; 
 (c) Borrower and each of its Subsidiaries has maintained
all records and is current with all reports and documents required to be filed with any state or federal securities commission or similar Governmental Authority and is in full compliance with all applicable rules and regulations of such commissions
except to the extent failure to be in such compliance could not reasonably be expected to cause a Material Adverse Effect. 
 (d) There are
no presently existing circumstances that would result or likely would result in material violations of any Medical Products Law. No Accounts have been generated in violation of any applicable Laws. 
 (e) Neither Borrower nor any of its Subsidiaries is currently, nor has in the past been, subject to any federal, state, local governmental or private
civil or criminal investigations, inquiries or audits involving and/or related to its compliance with Medical Products Laws or regarding its activities, including without limitation, an inquiry or investigation of any Person having “ownership,
financial or control interest” in Borrower or any of its Subsidiaries (as that phrase is defined in 42 C.F.R. §420.201 et seq.) involving compliance with Medical Products Laws. 
  

 28 

 (f) No Principal, owner, officer, manager, employee or Person with a “direct or indirect ownership
interest” (as that phrase is defined in 42 C.F.R. §420.201) in Borrower: (i) has been convicted (as that term is defined in 42 C.F.R. §1001.2) of any of those offenses described in 18 U.S.C. §§669, 1035, 1347, 1518; or
(ii) has been involved or named in a U.S. Attorney complaint made or any other action taken pursuant to the False Claims Act under 31 U.S.C. §§3729-3731 or qui tam action brought pursuant to 31 U.S.C. §3729 et seq. 
 Section 4.14. Environmental Matters. 
 (a) Except as described in the Information Certificate, (i) no use, exposure, release, generation, manufacture, storage, treatment, transportation or disposal of Hazardous Material has occurred or is occurring on
or from any Location, or off any Location, as a result of any action of Borrower or any of its Subsidiaries, (ii) all Hazardous Material used, treated, stored, transported to or from, generated or handled at the Locations, or off the Locations
by Borrower or any of its Subsidiaries, has been disposed of on or off the Locations by or on behalf of Borrower or any of its Subsidiaries in a lawful manner and (iii) there are no underground storage tanks present on or under the Locations
owned or leased by Borrower or any of its Subsidiaries. 
 (b) No other material environmental, public health or safety hazards exist with
respect to the Locations. Borrower has provided to Lender copies of all existing environmental reports, reviews and audits with respect to the Locations and all other written information pertaining to the actual or potential Environmental
Liabilities of Borrower or any of its Subsidiaries known to Borrower. 
 (c) Borrower and each of its Subsidiaries (i) shall comply in
all material respects with all applicable Environmental Laws, (ii) shall notify Lender in writing within seven (7) days after it becomes aware of any Release on, at, in, under, above, to, from or about any of the Locations, and
(iii) shall promptly forward to Lender a copy of any order, notice, permit, application or other communication or report received by it in connection with any such Release. 
 Section 4.15. Intellectual Property. 
 Each Borrower or Subsidiary of Borrower is the sole and exclusive owner of the entire right, title, and interest in and to, or has the valid right to use, all the patents, patent applications, trademarks, trademark
applications, service marks, service mark applications, goodwill, domain names, trade names, trade dress, copyrights, copyright applications, franchises, licenses, trade secrets, technology, inventions, formulae, recipes, compounds, know-how and
processes, and all applications therefor and rights with respect to the foregoing (collectively, “Intellectual Property”) necessary for the current conduct of its business, without any conflict with the rights of others and free and
clear of all liens and encumbrances. A list of all such Intellectual Property (indicating the nature of the interest of such Borrower or such Subsidiary), as well as all outstanding franchises and licenses given by or held by Borrower or any of its
Subsidiaries, is set forth in the Information Certificate. The Intellectual Property identified as “material” on the Information Certificate is all of the Intellectual Property necessary for the conduct of its current service business. All
Intellectual Property owned by and material to the business conducted by Borrower or any of its Subsidiaries is subsisting and has not been adjudged invalid or unenforceable, in whole or in part, and Borrower or such Subsidiary has performed all
acts and has paid all renewal, maintenance, and other fees and taxes required to maintain each and every registration and application of Copyrights, Patents and Trademarks set forth in the Information Certificate. Neither Borrower nor any of its
Subsidiaries is in default of any obligation or undertaking with respect to the Intellectual Property or related rights. No settlement or consents, covenants not to sue, nonassertion assurances, or releases (i) have been entered into by
Borrower or any of its Subsidiaries or (ii) to Borrower’s knowledge have been entered into by another Person but to which Borrower or any of its Subsidiaries is bound that adversely affect the rights of Borrower or any of its Subsidiaries
to own or use any Intellectual Property. In conducting its service business, neither Borrower nor any of its Subsidiaries is infringing on any Intellectual Property rights of others and Borrower is not aware of any infringement by others of any such
rights owned by Borrower or any of its Subsidiaries. No other party has threatened Borrower with any claim of infringement of any Intellectual Property rights of other related to the service business conducted by Borrower. As to its current
business, no holding, decision, or judgment has been rendered in any action or proceeding before any court or administrative authority challenging the validity of 

  

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Borrower’s or any of its Subsidiaries’ right to register, own, or use any Intellectual Property, and no such action or proceeding is pending or to
Borrower’s knowledge threatened. 
 Section 4.16. Capitalization. The authorized equity securities (whether capital
stock, partnership or membership interests or otherwise) of each entity comprising Borrower and each of its Subsidiaries are as set forth in the Information Certificate. All issued and outstanding equity securities of Borrower and each of its
Subsidiaries are duly authorized and validly issued, fully paid, nonassessable, free and clear of all Liens or pledges other than those in favor of Lender or for the benefit of Lender, and such equity securities were issued in compliance with all
applicable state, federal and foreign laws concerning the issuance of securities. The Information Certificate accurately states as of the Restatement Date (a) for any Stock of Borrower or any of its Subsidiaries that is publicly traded, the
holders of such Stock in excess of five percent (5%) of all such Stock on a fully diluted basis as of the execution date of this Agreement and the percentage of such holder’s fully diluted ownership of such Stock, and (b) for any
Stock of Borrower or any of its Subsidiaries that is not publicly traded, all holders of such Stock and the percentage of such holder’s fully diluted ownership of such Stock. No shares of the equity securities of Borrower or any of its
Subsidiaries, other than those described above, are issued and outstanding. Except as provided in the Information Certificate, there are no preemptive or other outstanding rights, options, warrants, conversion rights or similar agreements or
understandings for the purchase or acquisition from Borrower or any of its Subsidiaries of any equity securities of Borrower or such Subsidiary. 
 Section 4.17. Material Facts. Neither this Agreement nor any other Loan Document nor any other agreement, document, certificate, or statement furnished to Lender by or on behalf of Borrower or any of its Subsidiaries in
connection with the transactions contemplated by this Agreement contains any untrue statement of material fact or omits to state a material fact necessary to make the statements contained in this Agreement or other Loan Document not misleading. All
financial projections delivered to Lender by Borrower have been prepared on the basis of assumptions stated therein. Such projections represent Borrower’s best estimate of Borrower’s future financial performance and such assumptions are
believed by Borrower to be fair in light of current business conditions. 
 Section 4.18. Investments, Deposit Accounts,
Guarantees, and Certain Contracts. Borrower does not own or hold any equity or long-term debt investments in, have any outstanding advances to, have any deposit or other bank, investment or securities accounts, have any outstanding
guarantees for the obligations of, or have any outstanding borrowings from, any Person, except as described on the Information Certificate or as expressly permitted under Section 6.6. Neither Borrower nor any of its Subsidiaries is a
party to any contract or agreement, or subject to any corporate restriction, which adversely affects its business. 
 Section 4.19.
Business Interruption. There are no pending or threatened labor disputes, strikes, lockouts, or similar occurrences or grievances against Borrower or any of its Subsidiaries or the businesses of Borrower or any of its Subsidiaries.

 Section 4.20. Joint Ventures. Neither Borrower nor any of its Subsidiaries is engaged in any joint venture or
partnership with any other Person, except as set forth on the Information Certificate or as permitted in accordance with the terms of Section 6.2. 
 Section 4.21. Solvency. Both before and after giving effect to the transactions contemplated by the Loan Documents, and as of the date each advance or other accommodation in respect of a Credit
Facility is made, each entity comprising Borrower is Solvent. 
 Section 4.22. Government Contracts. Except as set forth
in the Information Certificate and except for Government Contracts for which Borrower has given Lender written notice in accordance with Section 5.18, no Borrower is a party to any contract or agreement (including, but not limited to,
any Lease) that is subject to the Federal Assignment of Claims Act, as amended (31 U.S.C. Section 3727, 41 U.S.C. Section 15) or any similar state or local law. Except as set forth in the Information Certificate, each Government Contract
includes a “no set-off commitment”. 
  

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 Section 4.23. OFAC. None of Borrower, any of its Subsidiaries nor any Principal is
currently listed on the OFAC Lists. 
 Section 4.24. Contracts. The Information Certificate sets forth an accurate,
complete and current list of all Material Borrower Contracts. 
 Section 4.25. No Broker. No brokerage commission or
finder’s fee is owing to any broker or finder arising out of any actions or activity of Borrower or any of its Subsidiaries in connection with the Loan. Borrower shall defend, indemnify and hold Lender harmless from and against any and all
claims for brokerage commission or finder’s fees arising out of or in connection with the Loan. 
 ARTICLE V 
 AFFIRMATIVE COVENANTS 
 Each
entity comprising Borrower covenants and agrees that for so long as Borrower may borrow under this Agreement and until payment and performance in full of the Obligations: 
 Section 5.1. Financial Statements and Collateral Reports. Borrower shall, and shall cause its Subsidiaries to, keep current and accurate books of records and accounts in which full and correct
entries will be made of all of its business transactions, and will reflect in its financial statements adequate accruals and appropriations to reserves. NimbleGen shall keep its books of records and accounts and reflect such accruals and reserves
and prepare and deliver all consolidated financial statements, in each case in accordance with GAAP, consistently applied. Borrower shall, and shall cause its Subsidiaries to, furnish to Lender the following financial information and reports:

 (a) within twenty-five (25) days after the end of each calendar month, (i) its consolidated balance sheet and related statements
of operations and cash flows as of the end of and for such month and the then elapsed portion of the Fiscal Year, setting forth in each case in comparative form the figures for the corresponding period or periods of (or, in the case of the balance
sheet, as of the end of) the previous Fiscal Year, all certified by its chief financial officer as presenting fairly in all material respects the financial condition and results of operations of Borrower and its consolidated Subsidiaries on a
consolidated basis in accordance with GAAP consistently applied, subject to normal year-end audit adjustments, (ii) internally prepared monthly financial statements and a sales and collections report and accounts receivable and accounts payable
aging schedules on a form acceptable to Lender, which shall include, but not be limited to, a report of sales, credits issued, and collections received and any right of set-off, counterclaim or other defense that exists against such sums,
(iii) a Borrowing Base Certificate, (iv) an update to the itemized list of Collateral located in Iceland as filed in Iceland to perfect Lender’s security interest in such Collateral showing any additions to the information contained
therein since such update was last provided, and (v) documentary evidence from the depository bank showing the account balances in each of the Icelandic Accounts; 
 (b) within ninety (90) days after the end of each Fiscal Year of Borrower, (i) its audited consolidated balance sheet and related statements of operations, shareholders’ equity and cash flows as of the
end of and for such year, setting forth in each case in comparative form the figures for the previous Fiscal Year, all reported on by independent public accountants of recognized national standing approved by Lender in its reasonable discretion
(without a “going concern” or like qualification or exception and without any qualification or exception as to the scope of such audit) to the effect that such consolidated financial statements present fairly in all material respects the
financial condition and results of operations of Borrower and its consolidated Subsidiaries on a consolidated basis in accordance with GAAP and (ii) an update to its Information Certificate to reflect any changes to the information contained
therein; 
 (c) annual projections, profit and loss statements, balance sheets, and cash flow reports (prepared on a monthly basis) for the
succeeding Fiscal Year within sixty (60) days after the end of each of Borrower’s Fiscal Years; 
  

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 (d) promptly upon receipt thereof, copies of any reports submitted to Borrower by the independent
accountants in connection with any interim audit of the books of Borrower and copies of each management control letter provided to Borrower by independent accountants; 
 (e) as soon as available, copies of all financial statements and notices provided by Borrower, or any Subsidiary of Borrower, to its equity holders; 
 (f) within 15 days of the end of every calendar month, evidence satisfactory to Lender that all federal, state and foreign taxes, including, without
limitation payroll taxes, that are due have been paid in full; 
 (g) such additional information, reports or statements regarding Borrower,
or any Subsidiary of Borrower, as Lender may from time to time reasonably request; and 
 With respect to clauses (a) and (b) above,
with respect to each report required under this Section 5.1, a certificate of Borrower’s chief financial officer, in form and substance reasonably acceptable to Lender, certifying that the information delivered is true, complete and
correct in all respects and, after due inquiry by the chief financial officer, that there exists no fact, event or circumstance that constitutes a Default. Such certificate shall set forth the information (including detailed calculations) required
to establish whether Borrower is in compliance with the requirements of this Agreement, including the financial covenants set forth on Exhibit A, as at the end of the period covered by the financial statements then being furnished and
providing backup calculations and other information as Lender shall reasonably deem necessary. 
 Section 5.2. Existence, Good
Standing, and Compliance with Laws. Borrower shall, and shall cause its Subsidiaries to, comply with the requirements of all applicable Laws and requirements of Governmental Authorities (including Environmental Laws and ERISA and the rules
and regulations thereunder). Borrower shall, and shall cause its Subsidiaries to, do or cause to be done all things necessary (a) to obtain and keep in full force and effect all corporate, limited liability company or limited liability
partnership existence, and all rights, licenses, permits, certificates of needs, regulatory approvals, privileges, and franchises (collectively, “Permits”) necessary (i) to the ownership of its or their properties or the
conduct of its or their businesses, except to the extent the failure to do so could not reasonably be expected to cause a Material Adverse Effect, and (ii) to comply in all material respects with all applicable current and future Laws of any
Governmental Authority having or claiming jurisdiction over any of them; (b) to maintain and protect the properties used or useful in the conduct of the operations of Borrower and its Subsidiaries, including, without limitation, the maintenance
at all times of such insurance upon its insurable property and operations as required by law or by the Loan Documents; and (c) to maintain all Permits free from restrictions or known conflicts that could materially impair their use or operation
or cause the Permits to be provisional, probationary or restricted in any way. 
 Section 5.3. Regulatory Matters.

 (a) Compliance with Applicable Laws. Borrower shall, and shall cause its Subsidiaries to, be in compliance with all applicable
Laws relating to operation of its business, including, without limitation, and to the extent applicable, the Federal Food, Drug, and Cosmetic Act, the Public Health Service Act, HIPAA, 42 U.S.C. Section 1320a-7(b) (Criminal Penalties Involving
Medicare or State Health Care Programs), commonly referred to as the “Federal Anti-Kickback Statute,” and the Social Security Act, as amended, Section 1877, 42 U.S.C. Section 1395nn (Prohibition Against Certain Referrals),
commonly referred to as “Stark Statute”, and all rules and regulations promulgated thereunder (collectively, “Medical Products Laws”). Borrower and each Subsidiary of Borrower (i) has maintained and shall continue to
maintain in all material respects all Governmental Approvals and Licenses, free from restrictions or known conflicts or encumbrance of any kind (including Liens other than the Liens under this Agreement) that would materially impair the ability of
Borrower or such Subsidiary of Borrower to continue its business as currently conducted or use or operate of any Location or would restrict in any way Borrower or such Subsidiary of Borrower to transfer or assign such Governmental Approval or
License to Lender pursuant to the terms of this Agreement, (ii) has maintained and shall continue to maintain all records required to be maintained by any Governmental Authority or otherwise, and (iii) has timely filed, or caused to be
timely filed, and shall continue to file, or cause to be filed, all cost reports and other report of every kind whatsoever, in each case as required by any Medical Products Law. Borrower shall, and shall cause its Subsidiaries to, promptly furnish
or cause to be furnished to Lender copies of all reports and correspondence it sends or receives relating to any loss or revocation (or threatened loss or revocation) of any License or other qualification described in this Article or any other
violation or possible violation of Medical Products Laws. 
  

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 (b) HIPAA Covered Entity. If (i) Borrower or any Subsidiary of Borrower becomes a
“covered entity” within the meaning of HIPAA, or (ii) Borrower or any Subsidiary of Borrower becomes subject to the “Administrative Simplification” provisions of HIPAA, Borrower or such Subsidiary, as the case may be,
shall be HIPAA Compliant. 
 (c) Investigations or Proceedings. Borrower shall, and shall cause its Subsidiaries to, promptly notify
Lender if Borrower, or any Subsidiary of Borrower, or any of the Collateral, becomes the subject of any investigation or proceeding by any Governmental Authority or receives notice of any violation issued by a Governmental Authority that would,
directly or indirectly, or with the passage of time, (i) have a Material Adverse Effect, (ii) result in the imposition of a fine or sanction, or (iii) modify, limit or result in the transfer, suspension, revocation or imposition of
probationary use of any of the Licenses. 
 Section 5.4. Legality. Borrower shall insure that the Credit Facilities and
each disbursement or advance under the Credit Facilities shall not be subject to any penalty or special tax, and shall not violate or be prohibited by any rule or regulation of any Governmental Authority. Borrower shall further insure that all
necessary consents, approvals and authorizations of any Governmental Authority for any such disbursement or advance shall have been obtained. 
 Section 5.5. Taxes and Charges. Borrower shall, and shall cause its Subsidiaries to, timely file all tax reports and pay and discharge all taxes, assessments and governmental charges or levies imposed upon Borrower or any
Subsidiary of Borrower, its income or profits, the Collateral or any of Borrower’s properties (or properties of any Subsidiary of Borrower) or any part thereof (collectively, “Charges”), before the same shall be in default and
before the date on which penalties attach thereto, as well as timely pay all lawful claims for labor, material, supplies or otherwise (collectively, “Mechanics Claims”) that, if unpaid, might become a Lien or charge upon the
Collateral. Borrower or any Subsidiary of Borrower, as the case may be, shall have the right to contest, in good faith by appropriate proceedings, the amount or validity of any such Charges or Mechanics Claims so long as (a) Borrower or such
Subsidiary shall have set aside on its books adequate reserve therefor in accordance with GAAP, and (b) Borrower’s title to, and its right to use, the Collateral is not adversely affected thereby and Lender’s Lien and priority on the
Collateral are not adversely affected, altered or impaired thereby. 
 Section 5.6. Insurance. Borrower shall, or shall
cause its Subsidiaries to, maintain adequate casualty, theft, business interruption, public liability, professional liability, product liability, automobile, employee dishonesty and workmen’s compensation insurance with the current insurers as
listed on Exhibit C, or other responsible companies reasonably satisfactory to Lender, in such amounts and against such risks as is customarily maintained by similar businesses and by owners of similar property in the same general area;
provided, however, that Borrower shall, at a minimum, carry insurance of the kind and in the amounts shown in Exhibit C. Borrower shall deliver to Lender endorsements to all of its (a) casualty and property insurance
policies naming Lender as sole lender loss payee, and (b) general liability, product liability and other liability policies naming Lender as an additional insured. Borrower shall direct all insurers under its casualty and property policies of
insurance to pay all proceeds payable thereunder (to the extent applicable to the Collateral) directly to Lender. Borrower shall promptly notify Lender of any loss, damage, or destruction to any material portion of the Collateral, whether or not
covered by insurance. Proceeds of insurance related to any loss, damage or destruction to any Collateral shall be applied to repay the Credit Facilities pursuant to Section 2.2(f); provided, however, so long as no Default
has occurred and is continuing (whether or not any such Default has resulted in acceleration pursuant to Section 8.2), Borrower may invest such proceeds within one hundred eighty (180) days of receipt thereof in assets of the
general type used in and useful to the business of Borrower, which investment may include the repair, restoration or replacement of the applicable assets thereof; provided, further, upon request of Borrower, Lender may waive the
requirement for Borrower to repay the Credit Facilities with such proceeds in Lender’s discretion. 
 Section 5.7.
Information; Visits and Inspections; Searches. 
 (a) Information/Visits. Lender may (i) visit and inspect any of the
properties of Borrower or any Subsidiary of Borrower, (ii) inspect, audit and make copies of or prepare extracts from Borrower’s, or any of its Subsidiary’s, minute books, books of account 

  

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and other records, including management letters prepared by Borrower’s auditors, and (iii) discuss the business affairs, finances and accounts of
Borrower with, and be advised as to the same by, the officers, management and independent accountants of Borrower with relevant knowledge. 
 (b) Searches. Before Closing and thereafter (as and when determined by Lender in its discretion), Lender shall have the right to perform UCC, judgment, tax lien and bankruptcy searches and searches of applicable organizational
records against Borrower or any Subsidiary of Borrower, the results of which are to be consistent with Borrower’s or such Subsidiary’s representations and warranties under any Loan Document, all at Borrower’s expense. 
 Section 5.8. Maintenance of Property. Borrower shall, and shall cause its Subsidiaries to, maintain, keep and preserve all of its
properties, including the Collateral, in good repair, working order and condition and make all necessary repairs, renewals, replacements and improvements thereto, so that the business as currently carried on in connection therewith may be properly
conducted at all times. 
 Section 5.9. Notification of Events of Default and Adverse Developments. Borrower shall, and
shall cause its Subsidiaries to, promptly notify Lender upon an Authorized Officer obtaining knowledge of the occurrence of: (a) any Default; (b) any event, development or circumstance whereby the financial statements previously furnished
to Lender fail in any material respect to present fairly, in accordance with GAAP, the financial condition and operational results of Borrower; (c) any judicial, administrative or arbitration proceeding pending against or affecting Borrower,
any Subsidiary of Borrower, or the Collateral, and any judicial or administrative proceeding known by Borrower, or any Subsidiary of Borrower, to be threatened against it that, if adversely decided, would be reasonably likely to result in a Material
Adverse Effect or that may expose Borrower, or any Subsidiary of Borrower, to uninsured liability of $25,000 or more; (d) a request to produce from, or the production of documents by Borrower or any Subsidiary of Borrower, to a Governmental
Authority; and (e) any other development in the business or affairs of Borrower, or any Subsidiary of Borrower, that would be reasonably likely to result in a Material Adverse Effect; in each case describing the nature of the event or
development. In the case of notification under clauses (a) and (b), Borrower should set forth the action Borrower proposes to take with respect to such event. 
 Section 5.10. Employee Benefit Plans. Borrower shall, and shall cause its Subsidiaries to, (a) comply with the funding requirements of ERISA with respect to the Plans for its employees, or will
promptly satisfy any accumulated funding deficiency that arises under Section 302 of ERISA; (b) furnish Lender, promptly after filing the same, with copies of all reports or other statements filed with the United States Department of
Labor, the Pension Benefit Guaranty Corporation, or the Internal Revenue Service with respect to all Plans covered by Title IV of ERISA, or that Borrower, or any member of a Controlled Group, may receive from such Governmental Authority with respect
to any such Plans; and (c) promptly advise Lender of the occurrence of any Reportable Event or Prohibited Transaction with respect to any such Plan and the action that Borrower or such member of a Controlled Group proposes to take with respect
thereto. Borrower shall, and shall cause its Subsidiaries to, make all contributions when due with respect to any multi-employer pension plan in which it participates and will promptly advise Lender: (w) the filing of any request for waiver of
the minimum funding standard with respect to any Plan; (x) upon its receipt of written notice of the assertion against Borrower or any Subsidiary of Borrower of a claim for withdrawal liability; (y) upon the occurrence of any event that
could reasonably be expected to trigger the assertion of a claim for withdrawal liability against Borrower or any Subsidiary of Borrower; and (z) upon the occurrence of any event that would place Borrower or any Subsidiary of Borrower in a
Controlled Group as a result of which any member (including Borrower) thereof that could reasonably be expected to be subject to a claim for withdrawal liability, whether liquidated or contingent. 
 Section 5.11. Collection of Accounts. Borrower shall, and shall cause its Subsidiaries to, continue to diligently collect its Accounts
in the ordinary course of business. 
 Section 5.12. Places of Business. Borrower shall give thirty (30) days’
prior written notice to Lender of any change in the location of any of its, or any of its Subsidiary’s, places of business, any places where its records concerning its Accounts are kept, of any places where the Collateral is kept, or the
establishment of any new, or the discontinuance of any existing, places of business. 
  

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 Section 5.13. Business Conducted. Borrower shall, and shall cause its Subsidiaries to,
continue in the business or lines of business currently conducted by it immediately before the Closing Date or that are reasonably related thereto. 
 Section 5.14. Bank Accounts. 
 (a) Borrower shall cause each securities, depository or disbursement account of
Borrower or any Subsidiaries of Borrower (other than any tax or payroll account) to be subject to a control agreement satisfactory to Lender in its reasonable discretion. Borrower shall not and shall not allow any Subsidiary to open or maintain any
securities, depository or disbursement accounts except upon thirty (30) days’ prior written notice to Lender and Borrower shall not, and shall not allow any Subsidiary to, use any such accounts until such time as the applicable securities
intermediary or depository institution, as the case may be, Borrower or such Subsidiary of Borrower, as the case may be, and Lender have entered into a control agreement satisfactory to Lender and in any event sufficient to perfect a first priority
lien and security interest in such account in favor of Lender. 
 (b) Borrower shall not allow the balances in its accounts held at the
National Bank of Iceland, account numbers 0111-38-100380 and 0111-26-000380 (the “Icelandic Accounts”), to exceed an aggregate amount of $400,000 without the prior written consent of Lender; provided, however, Borrower
may increase the aggregate amount of such balances at any time upon delivery of (i) two (2) Business Days advance written notice of its intention to deposit additional funds in its Icelandic Accounts and the amounts of such increase,
(ii) amendments and modifications to the filings made in the Icelandic filing office (in the correct form for filing in Icelandic filing office) necessary or advisable to ensure that Lender maintains its first priority security interest in all
funds on deposit in the Icelandic Accounts, and (iii) funds necessary to pay all stamp taxes and other fees, costs and expenses in connection with such amendment or modification to such Icelandic filings. 
 (c) Borrower shall not allow the balance in its deposit account number 2043136320 held at JPMorgan (the “JPMorgan Collateral Account”),
which balance is subject to a Lien in favor of JPMorgan, as permitted pursuant to Section 6.3(a), to exceed an aggregate amount of $225,000 without the prior written consent of Lender, and shall cause JPMorgan to automatically transfer
certain amounts in excess of $200,000 to Borrower’s operating account in accordance with that certain Blocked Account Control Agreement, dated as of November 14, 2006, among JPMorgan, Lender and Borrower, as amended, restated or otherwise
modified from time to time. 
 Section 5.15. Termination/Default of Contracts. Borrower shall notify Lender of any
(a) default or event of default under, (b) termination of (other than in accordance with its terms), or (c) failure of any party to renew, any of the Material Borrower Contracts (unless the default or event of default under,
termination of or failure to renew, such contract, as the case may be, could not reasonably be expected to cause a Material Adverse Effect) as soon as reasonably possible. 
 Section 5.16. Landlord Agreements, Mortgagee Agreements and Real Estate Purchases. Upon the request of Lender, Borrower shall obtain a
landlord’s agreement or mortgagee agreement, as applicable, from the lessor of each leased property or mortgagee of owned property with respect to any Location or other location where any portion of the Collateral, or the records relating to
such Collateral and/or software and equipment relating to such records or Collateral, is stored or located, which agreement or letter shall be reasonably satisfactory in form and substance to Lender. Borrower shall, and shall cause its Subsidiaries
to, timely and fully pay and perform its obligations under all leases and other agreements with respect to each leased location where any Collateral, or any records related thereto, is or may be located. 
 Section 5.17. Financial Covenants. Immediately prior to the making of initial Revolving Credit Loan, if any, and giving effect of such
Revolving Credit Loan, and at all times following the making of such initial Revolving Credit Loan (whether or not there remains any amounts outstanding under the Revolving Facility after such initial Revolving Credit Loan), Borrower shall comply
with and shall not breach any of the financial covenants set forth in Exhibit A. For purposes of Section 8.1, a breach of a financial covenant set forth in Exhibit A shall be deemed to have occurred as of the last day of
any specified measurement period, regardless of when the financials statements or other reports reflecting such breach are delivered to Lender. 
  

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 Section 5.18. Government Contracts. If Borrower proposes to enter into or suffer to
exist any Government Contract, the Accounts of which are included or are proposed to be included in the Borrowing Base, Borrower shall (a) promptly give Lender written notice of Borrower’s execution of or receipt of an award of a
Government Contract, (b) provide all necessary Assignment of Claims Documents, (c) ensure that Lender shall have the right to send to the Account Debtor in respect of such Government Contract such notices, and request such acknowledgments
of the Account Debtor, as Lender deems necessary to cause such Account Debtor to recognize the assignment of the Accounts and payment rights in respect thereof, and (d) use its best efforts to include in each Government Contract to which it is
a party a “no set-off commitment”. 
 Section 5.19. Lien Documents; Collateral Generally. 
 (a) At Closing and thereafter as Lender may request from time to time in its reasonable discretion, Borrower shall execute and deliver to Lender, or have
executed and delivered (all in form and substance satisfactory to Lender in its discretion) any agreements, documents, instruments, and writings deemed reasonably necessary by Lender to evidence, perfect, or protect Lender’s Lien and security
interest in the Collateral, whether now owned or hereafter acquired, required under this Agreement. 
 (b) Borrower shall bear the risk of
loss on all Collateral, regardless of whether such Collateral is in the possession or control of Borrower, Lender, a bailee or any other Person. 
 (c) Borrower hereby authorizes Lender to file all financing statements, continuations and amendments to financing statements describing the Collateral (which description may use the term “all assets” or words of similar import) in
any filing office as Lender, in its discretion may determine, in each case naming Borrower as debtor. Borrower agrees to comply with the requirements of all federal and state laws and requests of Lender in order for Lender to have and maintain a
valid and perfected first priority security interest in the Collateral including, without limitation, executing and causing any other person to execute such documents as Lender may require to obtain control (as defined in the UCC) over all deposit
accounts, electronic chattel paper, letter of credit rights, commercial tort claims and investment property to the extent a Lien is granted to Lender on such items under the Loan Documents. 
 (d) Borrower shall do and hereby authorizes Lender to do anything further that may be lawfully required by Lender to secure Lender’s interests in
the Collateral and effectuate the intentions of this Agreement. With respect to any property leased by Borrower, upon request of Lender, Borrower shall use commercially reasonable efforts to enter into, and cause any landlord to enter into a
Landlord’s Waiver and Consent in form and substance substantially similar to Exhibit E, attached hereto. 
 (e) Borrower shall
immediately deliver to Lender all items of Collateral in which Lender must take possession to obtain a perfected security interest (in each case, accompanied by stock powers, endorsements, allonges or other instruments of transfer duly executed in
blank), including all notes, certificates, and documents of title, chattel paper, warehouse receipts, instruments, and other similar instruments constituting Collateral. Where Collateral is in the possession of a third party, Borrower shall join
with Lender in notifying the third party of Lender’s security interests and obtain an acknowledgement from the third party that it is holding the Collateral for the benefit of Lender. 
 (f) Borrower shall not create any chattel paper without placing a legend on the chattel paper acceptable to Lender indicating that Lender has a security
interest in the chattel paper. 
 (g) Borrower shall promptly, and in any event within two (2) Business Days after the same is acquired
by Borrower, notify Lender of any (i) commercial tort claim with a claimed amount in excess of $50,000 acquired by Borrower, (ii) Account with a value in excess of $50,000 evidenced or secured by an instrument or chattel paper or has been
reduced to judgment, and (iii) additions to the Collateral located in Iceland the book value of which exceeds $125,000 in the aggregate. Borrower shall promptly deliver any such instrument or chattel paper to Lender, assign such judgment to
Lender or deliver all amendments and modifications to the filings made in the Icelandic filing office (in the correct form for filing in Icelandic filing office) together with the funds necessary to pay all stamp taxes and other fees, costs and
expenses in connection with the filing of such amendment or modification to such Icelandic filings to Lender, as the case may be, such that Lender shall have a first priority perfected security interest and lien upon such commercial tort claim,
instrument, chattel paper or judgment, or additional Collateral, as the case may be. 
  

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 Section 5.20. Additional Collateral Provisions. 
 (a) Performance Under Borrower Contracts. It is expressly agreed by Borrower that, notwithstanding anything herein to the contrary, Borrower shall
remain liable under each item of Collateral consisting of Borrower Contracts and Licenses to observe and perform all the conditions and obligations to be observed and performed by it thereunder, and Lender shall have no obligation or liability
whatsoever to any Person under any such Borrower Contract or License (between Borrower and any Person other than Lender) by reason of or arising out of the execution, delivery or performance of this Agreement. 
 (b) Accounting Reports. Upon the request of Lender, after the occurrence and during the continuance of an Event of Default (whether or not any
such Event of Default has resulted in acceleration pursuant to Section 8.2), Borrower, at its own expense, shall cause the public accounting firm then engaged by Borrower to promptly prepare and deliver to Lender at any time and from
time to time, the following reports: (i) a reconciliation of all Accounts and statement of inventory, including the results of any physical verifications of all or any portion of any inventory made or observed by such accountants when and if
such verification is conducted; (ii) an aging of all Accounts; (iii) trial balances; and (iv) test verifications of such Accounts. Lender shall be permitted to observe and consult with Borrower’s accountants in the performance of
these tasks. 
 (c) Lender License. For the purpose of enabling Lender to exercise its rights and remedies under the Loan Documents,
Borrower hereby grants and shall cause each of its Subsidiaries to grant to Lender an irrevocable, non-exclusive license (exercisable upon the occurrence and during the continuance of an Event of Default (whether or not any such Event of Default has
resulted in acceleration pursuant to Section 8.2) without payment of royalty or other compensation to Borrower) to use, transfer, license or sublicense any Intellectual Property now owned, licensed to, or hereafter acquired by Borrower
or any Subsidiary of Borrower, and wherever the same may be located, and including in such license access to all media in which any of the licensed items may be recorded or stored and to all computer and automatic machinery software and programs
used for the compilation or printout thereof, and represents, promises and agrees that any such license or sublicense is not and will not be in conflict with the contractual or commercial rights of any third Person; provided, that such
license will terminate upon the termination of Lender’s Liens in the Collateral. Borrower shall, and shall cause each of its Subsidiaries to, maintain and keep good and valid title to, and protect against infringement by others of, all of the
Intellectual Property necessary for the current and planned future conduct of its business and the manufacture and production of its products. 
 (d) Duty of Care. Lender shall have no duty of care with respect to the Collateral except that Lender shall exercise reasonable care with respect to the Collateral in Lender’s custody. Lender shall be deemed to have exercised
reasonable care if such property is accorded treatment substantially equal to that which Lender accords its own property or if Lender takes such action with respect to the Collateral as Borrower shall request or agree to in writing; provided,
that neither failure to comply with any such request nor any omission to do any such act requested by Borrower shall be deemed a failure to exercise reasonable care. Lender’s failure to take steps to preserve rights against any parties or
property shall not be deemed to be failure to exercise reasonable care with respect to the Collateral in Lender’s custody. 
 Section 5.21. Compliance With Anti-Terrorism Orders. Borrower shall immediately notify Lender if Borrower has knowledge that Borrower, any Subsidiary of Borrower or Principal is listed on the OFAC Lists or (a) is
indicted on or (b) arraigned and held over on charges involving money laundering or predicate crimes to money laundering. Borrower shall immediately notify Lender if Borrower knows that any party to a Material Borrower Contract or any other
party with which Borrower maintains any other material business arrangement is listed on the OFAC Lists or (w) is convicted on, (x) pleads nolo contendere to, (y) is indicted on or (z) is arraigned and held over on charges
involving money laundering or predicate crimes to money laundering. Neither Borrower nor any Subsidiary of Borrower shall knowingly enter into any transaction or arrangement with any party who is listed on the OFAC Lists. 
  

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 ARTICLE VI 
 NEGATIVE COVENANTS 
 Each entity comprising Borrower covenants and agrees that so long as
Borrower may borrow under this Agreement and until payment and performance in full of the Obligations: 
 Section 6.1.
Indebtedness. Borrower shall not, and shall not permit its Subsidiaries to, directly or indirectly, create, incur, assume, guarantee or otherwise become or remain liable for or suffer to exist any Indebtedness except: 
 (a) Indebtedness to Lender; 
 (b) Indebtedness
expressly denoted as permitted indebtedness in the Information Certificate and extensions, renewal and replacements of such indebtedness that do not increase the principal amount thereof or the aggregate amount of outstanding obligations thereunder
or the collateral (if any) securing such obligations, and pursuant to terms and conditions that are not less favorable to Lender than the Indebtedness being extended, renewed or replaced (collectively, “Permitted Indebtedness”);

 (c) Indebtedness of Borrower or any Subsidiary of Borrower incurred after the Closing Date consisting of capital lease obligations or
Indebtedness incurred to provide all or a portion of the purchase price of an asset; provided, that (i) such Indebtedness when incurred shall not exceed the purchase price of such asset, (ii) no such Indebtedness shall be refinanced
for a principal amount in excess of the principal balance outstanding thereon at the time of such refinancing, or on terms and conditions less favorable to Lender than the Indebtedness being refinanced; and (iii) the aggregate amount of all
such Indebtedness outstanding at any time shall not exceed $250,000; 
 (d) Indebtedness consisting of loans and advances (i) between
NimbleGen and NimbleGen Iceland, or (ii) of NimbleGen or NimbleGen Iceland owed to any other Subsidiary of NimbleGen; provided, that, in each case, such Indebtedness shall be evidenced by a promissory note in form and substance
reasonably acceptable to Lender, which promissory note shall be pledged and delivered, together with all necessary endorsements and transfer documents executed in blank, to Lender as additional collateral for the Obligations and shall be unsecured
and subordinate in all respects to the payment in full of the Obligations pursuant to the terms of such promissory note or an intercompany subordination agreement in form and substance reasonably acceptable to Lender (the “Intercompany Notes
(Unsecured)”). 
 (e) Indebtedness consisting of loans and advances of NimbleGen Germany owed to NimbleGen or NimbleGen Iceland, in
an aggregate amount not to exceed $500,000 at any time outstanding; provided, that, in each case, such Indebtedness shall be evidenced by a promissory note in form and substance reasonably acceptable to Lender, which promissory note shall be
pledged and delivered, together with all necessary endorsements and transfer documents executed in blank, to Lender as additional collateral for the Obligations and shall be secured (to the greatest extent reasonably possible under applicable law)
by Liens on substantially all of the assets of NimbleGen Germany (the “Intercompany Notes (Secured)” and together with the Intercompany Notes (Unsecured), collectively, the “Intercompany Notes”). 
 Borrower will not make prepayments on any existing or future Indebtedness to any Person (other than Lender, to the extent permitted by this Agreement or
any subsequent agreement between Borrower and Lender). Borrower will not make any payments (whether in cash, in kind or otherwise) in respect of any Permitted Indebtedness at a time such payments are otherwise prohibited under the terms of any
intercreditor agreement or subordination agreement or promissory note containing subordination terms. 
 Section 6.2. Joint
Ventures. Borrower shall not, and shall not permit its Subsidiaries to, invest directly or indirectly in any joint venture for any purpose without the prior written consent of Lender, which consent shall not be unreasonably withheld.

  

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 Section 6.3. No Liens and Encumbrances; No Disposition of the Collateral. Borrower
will not: 
 (a) create, incur, assume or suffer to exist any Lien upon, or any security interest in, any of the Collateral, whether now owned
or hereafter acquired, other than Permitted Liens, Liens in respect of Indebtedness permitted under Section 6.1(c) and Liens granted pursuant to that certain Security Agreement, dated as of November 14, 2006, made by Borrower and
acknowledged and accepted by JPMorgan regarding the JPMorgan Collateral Account, which Security Agreement shall not be amended, restated or otherwise modified without the prior written consent of Lender; 
 (b) create, incur, assume or suffer to exist any Lien upon, or any security interest in, any of Borrower’s Intellectual Property, whether now owned
or hereafter created or acquired; 
 (c) sell, exchange, lease or otherwise transfer, or grant any Person an option to acquire, directly or
indirectly, any of its properties or assets, other than (i) sales of Inventory for fair value in the ordinary course of businesses and (ii) dispositions for cash and fair value of Equipment, Fixtures, and other assets that the board of
directors of the applicable Borrower determines in good faith are no longer used or useful in its business; provided, that (x) immediately after any such disposition the aggregate fair market value of all such assets disposed of pursuant
to this clause (c)(ii) after the date hereof does not exceed $225,000 and the aggregate fair market value of all such assets disposed of during the Fiscal Year in which such disposition is made does not exceed $75,000, and (y) the net
proceeds of all such asset dispositions under this clause (c)(ii) are applied to prepay the Obligations; and 
 (d) license any of the
Collateral other than (i) license and distribution arrangements set forth on the Information Certificate, (ii) other license and distribution arrangement in replacement thereof on the same or similar terms, and (iii) other license and
distribution arrangements with respect to the same products entered into in the ordinary course of business on commercially reasonable terms. 
 Section 6.4. Restriction on Fundamental Changes. Borrower shall not, and shall not permit its Subsidiaries to: 
 (a) consolidate or merge with or into any other Person other than the merger of a wholly owned Subsidiary of Borrower with and into the Borrower; 
 (b) liquidate, wind-up or dissolve itself (or suffer any liquidation or dissolution); 
 (c) transfer,
assign, convey or grant to any other Person the right to operate or control any Location, whether by lease, sublease, management agreement, joint venture agreement or otherwise; 
 (d) without providing Lender with thirty (30) days’ prior written notice, change the jurisdiction of its organization, its organizational form
or its legal name; 
 (e) suffer or permit any change in the name, organizational documents or governing documents of Borrower or any
Subsidiary of Borrower without the prior written consent of Lender, including by filing or modification of any certificate of designation or any agreement or arrangement entered into by it with respect to any of its Stock (including any
shareholders’ agreement), or enter into any new agreement with respect to any of its Stock, except for changes that do not change the capital structure or jurisdiction of incorporation or formation, as the case may be, of Borrower or such
Subsidiary of Borrower or otherwise has no effect upon Lender’s rights and remedies hereunder or under the other Loan Documents, including, without limitation, Lender’s priority security interest in the Collateral (it being understood that
if Borrower that is a partnership or limited liability company, or any Subsidiary of Borrower that is a partnership or a limited liability company, amends or modifies its organizational documents to cause such partnership interests or membership
interests to be (a) dealt in or traded on securities exchanges or in securities markets, (b) become a security for the purposes of Article 8 of any relevant Uniform Commercial Code, (c) become an investment company security within the
meaning of Section 8-103 of any relevant UCC or (d) be evidenced by a certificate, such amendment or modification shall be deemed to change the capital structure of Borrower requiring the prior written consent of Lender). Borrower shall
deliver a copy of each such amendment to Lender promptly upon the adoption thereof. 
  

 39 

 (f) amend, modify or otherwise change its Fiscal Year; or 
 (g) consent to or acknowledge any of the foregoing. 
 Borrower agrees that compliance with this Section 6.4 is a material inducement to Lender’s advancing credit under this Agreement. Borrower further agrees that in addition to all other remedies available to Lender, Lender
shall be entitled to specific enforcement of the covenants in this Section 6.4, including injunctive relief, to the full extent permitted by applicable Laws. 
 Section 6.5. Distributions and Management Fees. Borrower shall not, and shall not permit any Subsidiary to, directly or indirectly declare, order, pay or make any “Distributions” (as
defined below) to any of its Affiliates, to any shareholder or other Person holding an equity interest in Borrower or to any other Person related to or affiliated with any of the foregoing, except that the foregoing, including without limitation,
any Principal, shall not restrict or prohibit wholly-owned Subsidiaries from making distributions or dividends to Borrower and shall not restrict Borrower or any Subsidiary from making Distributions to any wholly-owned Domestic Subsidiary;
provided, however, Borrower may pay reasonable salaries to officers or employees, and reasonable fees to directors, under customary benefit programs or arrangements for employees, officers or directors, including, without limitation,
equity based compensation programs, retirement or savings plans and similar plans, so long as (a) such payments, arrangements, programs and plans are in the ordinary course of business and consistent with past practice and (b) with respect
to executive officers and directors, such payments, arrangements, programs and plans shall have been approved by the board of directors of the Company. “Distributions” shall mean management fees, consulting fees, servicing fees, salaries
or other fees or compensation, lease or rental payments, repayments of or debt service on loans or other indebtedness, dividends or other distributions with respect to any of its stock, now or hereafter outstanding, the purchase, redemption or other
acquisition for value of any of its stock, now or hereafter outstanding, or the return of any capital of its equity holders. 
 Section 6.6. Investments. 
 Borrower shall not, and shall not permit its Subsidiaries to, directly or indirectly,
make or own any Investment in any Person, including, without limitation, any joint venture or general partnership, except (each of the following, collectively, the “Permitted Investments”): 
 (a) Cash and Cash Equivalents; 
 (b)
(i) equity Investments owned as of the Closing Date and described in the Information Certificate, it being agreed that the amount of any such Investment as of the Closing Date may not be increased due to additional Investments made after the
Closing Date and (ii) any Investment made after the Closing Date among entities comprising the Borrower; 
 (c) Investments consisting
of deposits, prepayments and other credits to suppliers made in the ordinary course of business consistent with past practice; 
 (d) loans
and advances to officers, directors or employees of Borrower and its Subsidiaries made in the ordinary course of business in an aggregate principal amount at any time outstanding not to exceed $25,000 in the aggregate; 
 (e) Investments consisting of loans and advances related to Indebtedness permitted pursuant to Sections 6.1(d) and (e), 
 (f) advances for business travel and similar temporary advances made in the ordinary course of business to officers, equity holders, directors, and
employees of Borrower in the aggregate at any time outstanding not to exceed $10,000 
  

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 (g) Investments in the ordinary course of business consisting of (i) endorsements for collection or
deposit and (ii) customary trade arrangements with customers consistent with past practice. 
 Section 6.7.
Subsidiaries. Except as expressly permitted under Section 6.6, Borrower shall not, and shall not permit its Subsidiaries to, form or acquire any Subsidiary, or make any investment in or any loan in the nature of an investment
to, any other Person. 
 Section 6.8. Compliance with ERISA. Borrower shall not, and shall not permit its Subsidiaries to,
allow, with respect to any Plan covered by Title IV of ERISA, any action that could reasonably be expected to result in Prohibited Transaction or any Reportable Event. 
 Section 6.9. Licenses. Borrower shall not, and shall not permit its Subsidiaries to, amend, alter or suspend or terminate or make provisional in any material way, any License listed on the
Information Certificate or any other License that becomes necessary for the operation of Borrower’s or such Subsidiary’s business and the commercial distribution of its products or for the ownership or operation of any Location.

 Section 6.10. Transactions with Affiliates. Borrower shall not, and shall not permit its Subsidiaries to, enter into
any transaction with any Affiliate or Subsidiary of Borrower, other than transactions expressly permitted by Sections 6.1, 6.4, 6.5 or 6.6, except in the ordinary course of business and pursuant to the reasonable requirements of
Borrower’s business or the business of such Subsidiary, as the case may be, and upon terms substantially the same and no less favorable to Borrower or such Subsidiary, as the case may be, as it would obtain in a comparable arm’s length
transaction with any Person not such an Affiliate or Subsidiary, and so long as the transaction is not otherwise prohibited under this Agreement. 
 Section 6.11. Use of Lender’s Name/Press Releases. Borrower shall not, and shall not permit its Subsidiaries to, use Lender’s name (or the name of any of Lender’s Affiliates, including without limitation,
GE Healthcare Financial Services, Inc.) in connection with any of its business operations. Borrower will not and will not permit its Affiliates to, in the future, issue any press release or other public disclosure using the name of Lender or any of
its Affiliates or referring to this Agreement or the other Loan Documents without the prior written consent of Lender unless (and only to the extent that) Borrower or such Affiliate of Borrower is required to so disclose under law and then, in any
event, such Borrower or Affiliate will consult with Lender before issuing such press release or other public disclosure. Borrower and each Subsidiary of Borrower consents to the publication by Lender of a tombstone or similar advertising material
relating to the financing transactions contemplated by this Agreement. Borrower or any Subsidiary of Borrower may disclose to third parties that Borrower has a borrowing relationship with Lender. 
 Section 6.12. Contracts and Agreements/No Negative Pledge. Borrower shall not, and shall not permit any Subsidiary to, become or be a
party to any contract or agreement, other than this Agreement, (a) that would breach this Agreement or any other Borrower Contract, (b) prohibiting the creation or assumption of any Lien upon its property or assets, whether now owned or
hereafter acquired, or (c) that would create or otherwise cause to suffer to exist or become effective, any consensual encumbrance or restriction on the ability of Borrower to pay any Indebtedness, transfer any of its property or assets or make
any loans or advances. 
 Section 6.13. Margin Stock. Borrower shall not, and shall not permit any Subsidiary to, use the
proceeds of a Loan to carry or purchase any “margin security” within the meaning of Regulations U, T or X of the Board of Governors of the Federal Reserve System. 
 Section 6.14. Truth of Statements and Certificates. Borrower will not furnish to Lender any certificate or other document that
contains any untrue statement of a material fact or that omits to state a material fact necessary to make it not misleading in light of the circumstances under which it was furnished. 
 Section 6.15. Capital Markets. Borrower shall not, and shall not permit any Subsidiary to, issue, offer or sell its debt or equity
securities in any public or private capital market unless: (a) such issuance, offer or sale would not cause or would not reasonably be expected to cause a material adverse change in, or material adverse effect upon any of (i) the financial
condition, operations, business, properties or prospects of Borrower or such Subsidiary, (ii) the rights and remedies of Lender under any Loan 

  

 41 

 
Document, or the ability of Borrower or such Subsidiary to perform any of its obligations under any Loan Document to which it is a party, (iii) the
legality, validity or enforceability of any Loan Document, or (iv) the existence, perfection or priority of any security interest granted in any Loan Document or the value of any material Collateral and (b) no Default has occurred and is
continuing. 
 ARTICLE VII 
 SECURITY AGREEMENT; PROVISIONS RELATING TO 
 ACCOUNTS COLLATERAL AND INVENTORY COLLATERAL 
 Section 7.1. Grant of Security Interest. As security for the prompt payment and performance of the Obligations whether at stated
maturity, by acceleration or otherwise, Borrower hereby grants, pledges and assigns to Lender a continuing first priority Lien on and security interest in, upon, and to, all right, title and interest in and to any and all property and interests in
property of Borrower whether now owned or hereafter created, acquired or arising, including all of the following properties and interests in properties (collectively, the “Collateral”): 
  

	 	(a)	all Accounts; 

  

	 	(b)	all Chattel Paper (whether tangible or electronic); 

  

	 	(c)	all Commercial Tort Claims, as more particularly described in the Information Certificate; 

  

	 	(d)	all Deposit Accounts; 

  

	 	(e)	all Documents; 

  

	 	(f)	all Equipment; 

  

	 	(g)	all Fixtures; 

  

	 	(h)	all Goods; 

  

	 	(i)	all Instruments; 

  

	 	(j)	all Inventory; 

  

	 	(k)	all Investment Property and Financial Assets; 

  

	 	(l)	all Letter-of-Credit Rights; 

  

	 	(m)	all Payment Intangibles, and General Intangibles; 

  

	 	(n)	the Stock of Borrower identified in the Information Certificate under the name of such Borrower and all other shares of capital stock or other equity interests of whatever class,
now or hereafter owned by Borrower, and all certificates evidencing the same (collectively, the “Pledged Securities”), together with, in each case: 

  

	 	(i)	all shares, securities, Stock, moneys or property representing a dividend on any of the Pledged Securities, or representing a distribution or return of capital upon or in respect of
the Pledged Securities, or resulting from a split-up, revision, reclassification or other like change of the Pledged Securities or otherwise received in exchange therefor, and any subscription warrants, rights or options issued to the holders of, or
otherwise in respect of, the Pledged Securities, and 

  

	 	(ii)	 without affecting the obligations of such Borrower under any provision prohibiting such action hereunder, in the event of any consolidation or merger in which the
issuer of any Pledged Security is not the surviving entity, all shares of each class of the capital stock of the successor corporation (unless such successor corporation is such Borrower itself), or all other Stock, as applicable, formed by or
resulting from such consolidation or 

  

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merger (the Pledged Securities, together with all other certificates, shares, securities, Stock, properties or moneys as may from time to time be pledged
hereunder pursuant to this clause (ii) and clause (i) above being herein collectively called the “Securities Collateral”); 

  

	 	(o)	all Borrower Contracts; 

  

	 	(p)	all Pledged Debt; 

  

	 	(q)	all Securities Entitlements; 

  

	 	(r)	all Software; 

  

	 	(s)	all other tangible and intangible personal property whatsoever of such Borrower; and 

  

	 	(t)	all Proceeds, Supporting Obligations, products, offspring, accessions, rents, profits, income, benefits, substitutions and replacements of and to any of the Collateral and, to the
extent related to any Collateral, all books, correspondence, credit files, records, invoices and other documents (including, without limitation, all tapes, cards, computer runs and other documents and documents in the possession or under the control
of such Borrower or any computer bureau or service company from time to time acting for such Borrower); 

 provided, however, in
no event shall the security interest granted under this Section 7.1 attach to (i) any of the outstanding Stock of a Subsidiary other than a Domestic Subsidiary in excess of 65% of the voting power of all classes of Stock of such
Subsidiary entitled to vote, (ii) any Intellectual Property of Borrower or (iii) any lease, license, contract, property rights or agreement to which Borrower is a party or any of its rights or interests thereunder if and for so long as the
grant of such security interest shall constitute or result in (A) the abandonment, invalidation or unenforceability of any right, title or interest of the Borrower therein or (B) in a breach or termination pursuant to the terms of, or a
default under, any such lease, license, contract property rights or agreement (other than to the extent that any such term would be rendered ineffective pursuant to Sections 9-406, 9-407, 9-408 or 9-409 of the UCC (or any successor provision or
provisions) of any relevant jurisdiction or any other applicable law (including the Bankruptcy Code) or principles of equity); provided, however, that such security interest shall attach immediately at such time as the condition causing such
abandonment, invalidation or unenforceability shall be remedied and to the extent severable, shall attach immediately to any portion of such lease, license, contract, property rights or agreement that does not result in any of the consequences
specified in clause (A) or (B) above. 
 Section 7.2. Security Agreement. This Agreement shall constitute a
security agreement as that term is used in the Uniform Commercial Code in effect in the jurisdiction(s) in which Borrower is organized and in the jurisdiction(s) in which the Collateral is situated. 
 Section 7.3. Preservation of Security Interests. In addition to the provisions of Sections 5.1(a), 5.14 and 5.19, Borrower
shall, upon request of Lender, furnish to Lender such further information, execute and deliver to Lender such documents and instruments (including, without limitation, Uniform Commercial Code financing statements) and shall do such other acts and
things as Lender may at any time reasonably request relating to the perfection or protection of the security interest created by this Agreement or for the purpose of carrying out the intent of this Agreement. Without limiting the foregoing, Borrower
shall cooperate and do all acts deemed necessary or advisable by Lender to continue a perfected first security interest in the Collateral, subject only to Permitted Liens, and shall obtain and furnish to Lender any subordinations, releases, landlord
waivers, lessor waivers, mortgage waivers, or control agreements, and similar documents as may be from time to time requested by, and in form and substance satisfactory to Lender. Borrower authorizes Lender to file a financing statement and
amendments thereto describing the Collateral as “all assets”, or words of similar import, and containing any other information required by the applicable Uniform Commercial Code. Borrower irrevocably grants to Lender the power to sign
Borrower’s name and generally to act on behalf of Borrower to execute and file applications for title, transfers of title, financing statements, notices of lien and other documents pertaining to any or all of the Collateral, obtain and promptly
deliver to Lender such certificate showing the lien of this Agreement with respect to the Collateral. 
  

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 Section 7.4. Accounts Administration. 
 (a) All data and other information relating to Accounts or other intangible Collateral shall at all times be kept by Borrower at its principal office(s)
as set forth on the Information Certificate and, except in the ordinary course of business in which case Lender shall be promptly notified in writing no later than ten (10) Business Days after such move, shall not be moved from such locations
without obtaining the prior written consent of Lender, which consent shall not be unreasonably withheld. 
 (b) Borrower shall keep accurate
and complete records of its Accounts and all payments and collections thereon and sales thereof and shall submit to Lender on such periodic basis as Lender shall reasonably request a sales and collections report for the preceding period, in form
satisfactory to Lender. In addition, if an Accounts becomes ineligible because it falls within one of the specified categories of ineligibility set forth in the definition of Eligible Accounts or otherwise, Borrower shall notify Lender of such
occurrence no later than the third Business Day following Borrower obtaining knowledge of such occurrence and the Borrowing Base shall thereupon be adjusted to reflect such occurrence. 
 (c) If an Event of Default has occurred and is continuing (whether or not any such Event of Default has resulted in acceleration pursuant to
Section 8.2), any of Lender’s officers, employees or agents shall have the right, at any time or times hereafter, in the name of Lender or any designee of Lender, to verify the validity, amount or any other matter relating to any
Accounts by mail, telephone or otherwise, including, but not limited to, verification of Borrower’s compliance with applicable Laws. Borrower shall cooperate fully with Lender in an effort to facilitate and promptly conclude such verification
process. Such verification may include contacts between Lender and applicable federal, state and local regulatory authorities having jurisdiction over Borrower’s affairs, all of which contacts Borrower hereby irrevocably authorizes. 

(d) Lender shall have the right at any time to notify Account Debtors that Accounts have been assigned to Lender and, following the occurrence of an
Event of Default (whether or not any such Event of Default has resulted in acceleration pursuant to Section 8.2), that payment of such Accounts shall be made directly by such Account Debtors to Lender (and once such notice has been given
to an Account Debtor, Borrower shall not give any contrary instructions to such Account Debtor without Lender’s prior written consent). 
 (e) No Borrower has made, or will make, any agreement with any Account Debtor for any extension of the time for payment of the Account, any compromise or settlement for less than the full amount thereof, any release of any Account Debtor
from liability therefor, or any deduction therefrom except a discount or allowance for prompt or early payment allowed by Borrower in the ordinary course of its business consistent with its historical practices and as previously disclosed to Lender
in writing. 
 ARTICLE VIII 
 EVENTS OF DEFAULT 
 Section 8.1. Events of Default. Each of the following (individually, an
“Event of Default” and collectively, the “Events of Default”) shall constitute an event of default under this Agreement (all cure periods provided for in this Section shall run concurrently with any cure period
provided for in any Loan Document in which “Events of Default” are specified): 
 (a) Borrower shall fail to pay when due any
principal, interest, premium or fee under this Agreement, any Note or other Loan Document or any other amount payable under any Loan Document; 
 (b) a default in the due observance or performance by Borrower of the Obligations of any other term, covenant or agreement contained any of Articles VI, VII or Section 5.17; provided, however, any such default in
the due observance or performance of the Obligations of any term, covenant or agreement contained in Sections 5.17, 6.1, 6.2, 6.5, 6.6, 6.7, 6.8, 6.9, 6.10 or 6.13 shall constitute an Event of Default only with respect to the Revolving Facility;

  

 44 

 (c) a default in the due observance or performance by Borrower of the Obligations of any term, covenant
or agreement other than any such term referred to in any other provision of this Section 8.1, and such default shall not have been remedied or waived within fifteen (15) days after the earlier of (i) an officer of Borrower
becoming aware of such default or (ii) receipt by Borrower of notice from Lender of such default; provided, however, any such default in the due observance or performance of the Obligations of any such term, covenant or agreement
contained in Sections 5.1(b)(i) (regarding only a “going concern” or like exception or qualification on Borrower’s audited financial statements), 5.3, 5.10, 5.11, 5.13, 5.15, 5.16, 5.18 or Exhibit D shall constitute an Event of
Default only with respect to the Revolving Facility; 
 (d) any representation, warranty or certification made by, or on or behalf of,
Borrower, or any officer of Borrower, in any of the Loan Documents, any financial statement, or any statement or representation made in any other certificate delivered in connection with the Loan Documents proves to have been incorrect or misleading
in any material respect when made; provided, however, such any representation, warranty or certification made pursuant to Sections 4.11, 4.12, 4.14, 4.18, 4.19, 4.20, 4.22, 4.24 or 4.25 that proves to have been incorrect or misleading
in any material respect when made shall constitute an Event of Default only with respect to the Revolving Facility; 
 (e) Borrower or any
Subsidiary of Borrower shall fail to make any payment when due in respect of any Indebtedness, other than the Obligations; 
 (f) any event
or condition shall occur which (i) results in the acceleration of the maturity of any Indebtedness, other than the Obligations, (ii) enables (or, with the giving of notice or lapse of time or both, would enable) the holder or holders of
any Indebtedness, other than the Obligations, or any Person acting on such holder’s behalf, to accelerate the maturity of any such Indebtedness, or (iii) results in a violation of, or a default under, any provision of the certificate of
incorporation, certificate of formation or certificate of limited liability partnership, bylaws, operating agreement, limited liability company interest, partnership agreement or similar document of Borrower or any Subsidiary of Borrower;

 (g) Borrower or any Subsidiary of Borrower makes an assignment for the benefit of creditors, offers a composition or extension to
creditors, or makes or sends notice of an intended bulk sale of any business or assets now or hereafter conducted or owned by Borrower or such Subsidiary of Borrower; 
 (h) Borrower or any Subsidiary of Borrower shall (i) commence a voluntary case or other proceeding seeking liquidation, reorganization or other relief with respect to itself or its debts under any bankruptcy,
insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other similar official of it or any substantial part of its properties or assets, (ii) consent to any such
relief or to the appointment of or taking possession by any such official in an involuntary case or other proceeding commenced against it, (iii) cease to be Solvent, make a general assignment for the benefit of creditors or (iv) fail
generally, shall not be able or shall admit in writing its inability, to pay its debts as they become due, or shall take any action in furtherance of, or indicating its consent to, or approval of or acquiescence in any of the foregoing; 

(i) an involuntary case or other proceeding shall be commenced against Borrower or any Subsidiary of Borrower seeking liquidation, reorganization or
other relief with respect to it or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other similar official of it or any substantial
part of its property, and such involuntary case or other proceeding shall remain undismissed and unstayed for a period of sixty (60) days, or an order for relief shall be entered against Borrower or any Subsidiary of Borrower under any
bankruptcy laws as now or hereafter in effect, or Borrower or any Subsidiary of Borrower shall take any action in furtherance of, or indicating its consent to, or approval of or acquiescence in any of the foregoing; 
 (j) any judgment, order or final settlement for the payment of money (less the proceeds of any insurance coverage applicable thereto and as to which the
insurance company has acknowledged coverage), which individually equals or exceeds $100,000 or when aggregated with other such judgments, orders or final settlements equals or exceeds $250,000, shall be rendered against any Borrower or Subsidiary of
Borrower and such judgment, order or final settlement shall continue unsatisfied and unstayed for a period of ten (10) days; 
  

 45 

 (k) (i) the institution of any steps by Borrower or any member of the Controlled Group or any other
Person to terminate a Pension Plan if as a result of such termination Borrower or any member of the Controlled Group could reasonably be expected to be required to make a contribution to such Pension Plan, or could incur a liability or obligation to
such Pension Plan, in excess of $50,000; (ii) a contribution failure occurs with respect to any Pension Plan sufficient to give rise to a Lien under Section 302 of ERISA; (iii) there shall occur any withdrawal or partial withdrawal
from a Multiemployer Plan and the withdrawal liability (without unaccrued interest) to Multiemployer Plans as a result of such withdrawal (including any outstanding withdrawal liability that Borrower and the members of the Controlled Group have
incurred on the date of such withdrawal) exceeds $50,000; (iv) with respect to any Plan, Borrower or any member of the Controlled Group shall incur an accumulated funding deficiency or request a funding waiver from the IRS; or (v) there
shall occur an ERISA Event or a non-exempt prohibited transaction within the meaning of Section 406 of ERISA or IRC Section 4975; provided, however, that the events listed in clauses (iv) and (v) hereof shall
constitute Events of Default only if the liability, deficiency or waiver request, whether or not assessed, could reasonably be expected to have, either individually or in the aggregate, a Material Adverse Effect; provided, further, any
such event listed in clauses (i) through (iv) hereof shall constitute an Event of Default only with respect to the Revolving Facility; 
 (l) (i) any member of a Controlled Group shall engage in any “prohibited transaction” (as defined in Section 406 of ERISA or Section 4975 of the IRC) involving any Plan; (ii) any “accumulated funding
deficiency” (as defined in Section 302 of ERISA), whether or not waived, shall exist with respect to any Plan or any Lien in favor of the PBGC or a Plan (other than a Permitted Lien) shall arise on the assets of Borrower or any Controlled
Group; (iii) a Reportable Event shall occur with respect to, or proceedings shall commence to have a trustee appointed, or a trustee shall be appointed, to administer or to terminate, any Single Employer Plan, with Reportable Event or
commencement of proceedings or appointment of a trustee is, in the reasonable opinion of the Lender, likely to result in the termination of such Plan for purposes of Title IV of ERISA; (iv) any Single Employer Plan shall terminate for purposes
of Title IV of ERISA; (v) Borrower, any Subsidiaries of Borrower or any Controlled Group shall, or in the reasonable opinion of the Lender is likely to, incur any liability in connection with a withdrawal form, or the insolvency or
reorganization of, any Multi-employer Plan; or (vi) any other similar event or condition shall occur or exist with respect to a Plan; and in each case in clauses (i) through (vi) hereof, such event or condition, together with all
other such events or conditions, if any, could reasonably be expected to have a Material Adverse Effect; provided, however, the occurrence of any such event or condition listed in clauses (i) through (vi) hereof shall
constitute an Event of Default only with respect to the Revolving Facility; 
 (m) any material damage to, or loss, theft or destruction of,
any Collateral, whether or not insured, or any strike, lockout, labor dispute, embargo, condemnation, act of God or public enemy, or other casualty which causes, for more than fifteen (15) consecutive days, the cessation or substantial
curtailment of revenue producing activities at any Location of Borrower, if any such event or circumstance, individually or in the aggregate, could reasonably be expected to have a Material Adverse Effect; 
 (n) any material provision of any Loan Document shall for any reason cease to be valid, binding and enforceable against Borrower for any reason, or
Borrower or any Subsidiary of Borrower shall so assert in writing or the Lien created by any of the Collateral Documents shall at any time fail to constitute a valid and perfected Lien on any portion of the Collateral purported to be secured thereby
which is deemed material by the Lender, subject to no prior or equal Lien except Permitted Liens, or Borrower or any Subsidiary of Borrower shall so assert in writing; 
 (o) there shall have occurred a Change of Control; 
 (p) Borrower, any Subsidiary of Borrower or any of its
respective directors or senior officers, including any Principal, is criminally indicted or convicted of or under a law that could lead to a forfeiture of Collateral; provided, however, any such indictment or conviction shall
constitute an Event of Default only with respect to the Revolving Facility; 
 (q) Borrower or any Subsidiary of Borrower shall be
prohibited, enjoined or otherwise materially restrained from conducting the business theretofore conducted by it by virtue of any determination, ruling, decision, decree or order of any Governmental Authority and such determination, ruling,
decision, decree or order remains unstayed and in effect for any period of ten (10) days beyond any period for which any business interruption insurance policy of the Borrower or any Subsidiary of Borrower 

  

 46 

 
shall provide full coverage to such Borrower or Subsidiary of Borrower with respect to any losses and lost profits; provided, however, any such
prohibition, enjoinment or restraint shall constitute an Event of Default only with respect to the Revolving Facility; 
 (r) any default by
Borrower or any Subsidiary of Borrower under the terms of any Material Borrower Contract, following the expiration of any applicable notice and cure period, shall have occurred and such default has or could reasonably be expected to have a Material
Adverse Effect; provided, however, the occurrence of any such default shall constitute an Event of Default only with respect to the Revolving Facility; 
 (s) the loss, suspension or revocation of, or failure to renew, any license or permit now held or hereafter acquired by Borrower or any Subsidiary of Borrower, if such loss, suspension, revocation or failure to renew,
individually or in the aggregate, could reasonably be expected to have a Material Adverse Effect; provided, however, any such loss, suspension, revocation or failure shall constitute an Event of Default only with respect to the
Revolving Facility; and 
 (t) there is a material adverse change in Borrower’s financial condition or there shall have occurred any
event or condition that is reasonably likely to result in a material adverse effect on Borrower’s business, prospects or financial condition as determined solely by Lender. 
 Notwithstanding (i) the foregoing or any other provision of this Agreement to the contrary, any action, default, event or condition constituting an
Event of Default only with respect to the Revolving Facility that results in the declaration of acceleration of the Obligations under or related to the Revolving Note pursuant to Section 8.2, other than a breach of the covenant contained
in Section 5.17, shall also be deemed to be an Event of Default with respect to the Term Facility, and (ii) any provision of this Agreement which makes reference to the continuance of a Default, nothing in this Agreement shall be
construed to permit Borrower or any Subsidiary to cure a Default following the lapse of the applicable cure period, and neither Borrower nor any Subsidiary of Borrower shall have any such right in any instance unless specifically granted in writing
by Lender. 
 Section 8.2. Acceleration. 
 Upon the occurrence of any of the foregoing Events of Default, the Obligations under or related to the Notes shall become immediately due and payable and the obligation to lend under the Revolving Facility will
terminate, each upon declaration to that effect delivered by Lender to Borrower; provided, however, upon the occurrence of any action, default, event or condition constituting an Event of Default only with respect to the Revolving
Facility, only the Obligations under or related to the Revolving Note shall become immediately due and payable and the obligation to lend under the Revolving Facility will terminate, each upon declaration to that effect delivered by Lender to
Borrower; provided, further upon the happening of any event specified in Sections 8.1(g), (h) or (i), all Obligations shall be immediately due and payable without declaration or other notice to Borrower, in each case,
including, without limitation any deferred commitment fees, exit fees or other fees due upon any termination of this Agreement. For avoidance of doubt, in no event shall the Lender accelerate the Term Facility based solely on a breach of the
covenant contained in Section 5.17. 
 Section 8.3. Remedies. 
 (a) Upon the occurrence of and during the continuance of an Event of Default, Lender, in addition to all other rights, options, and remedies granted to
Lender under this Agreement or at law or in equity, may take any of the following steps (which list is given by way of example and is not intended to be an exhaustive list of all such rights and remedies): 
 (i) Terminate the Credit Facilities, whereupon all outstanding Obligations (including, without limitation any deferred commitment fees or other fees due
upon any termination of this Agreement) shall be immediately due and payable; provided, however, upon the occurrence and during the continuance of any action, default, event or condition constituting an Event of Default only with
respect to the Revolving Facility, Lender may only terminate the Revolving Facility; 
  

 47 

 (ii) Exercise all other rights granted to it under this Agreement and the other Loan Documents and all
rights under the UCC in effect in the applicable jurisdiction(s) and under any other applicable laws; and 
 (iii) Exercise, either directly
or through one or more assignees or designees, all rights and remedies under all Loan Documents now or hereafter in effect, including but not limited to: 
 (A) The right to take possession of, send notices regarding, and collect directly the Collateral, with or without judicial process; 
 (B) The right to (by its own means or with judicial assistance) enter any of Borrower’s premises and take possession of the Collateral, or render it unusable, or dispose of the Collateral on such premises in
compliance with subsection (C) below, without any liability for rent, storage, utilities, or other sums, and Borrower shall not resist or interfere with such action; 
 (C) The right to require Borrower at Borrower’s expense to assemble all or any part of the Collateral and make it available to Lender at any place
designated by Lender; 
 (D) The right to use the Collateral and/or funds in the Lender’s Concentration Account and other cash pledged
to Lender in satisfaction of the Obligations; and 
 (E) The right to enforce Borrower’s rights against Account Debtors and other
obligors, including, but not limited to, the right to collect Accounts directly in Lender’s own name and to charge the collection costs and expenses, including attorneys’ fees, to Borrower. 
 (b) Borrower hereby irrevocably designates, makes, constitutes and appoints Lender (and all persons designated by Lender) as Borrower’s true and
lawful attorney-in-fact, and authorizes Lender, in Borrower’s name, to, following the occurrence and during the continuance of an Event of Default (whether or not any such Event of Default has resulted in acceleration pursuant to
Section 8.2): (i) demand payment of Borrower’s Accounts; (ii) enforce payment of Borrower’s Accounts by legal proceedings or otherwise; (iii) exercise all of Borrower’s rights and remedies with respect to
proceedings brought to collect an Account; (iv) sell or assign any Account upon such terms, for such amount and at such time or times as Lender deems advisable; (v) settle, adjust, compromise, extend or renew an Account;
(vi) discharge and release any Account; (vii) prepare, file and sign Borrower’s name on any proof of claim in bankruptcy or other similar document against an Account Debtor of Borrower; (viii) notify the post office authorities
to change the address for delivery of Borrower’s mail to an address designated by Lender, and open and deal with all mail addressed to Borrower; (ix) do all acts and things that are necessary, in Lender’s sole discretion, to fulfill
Borrower’s obligations under this Agreement; (x) take control in any manner of any item of payment or proceeds thereof; (xi) have access to any lockbox or postal box into which Borrower’s mail is deposited; (xii) endorse
Borrower’s name upon any items of payment or proceeds thereof and deposit the same in Lender’s account on account of the Obligations; (xiii) endorse Borrower’s name upon any chattel paper, document, instrument, invoice, or
similar document or agreement relating to any Account or any goods pertaining thereto; and (xiv) sign Borrower’s name on any verification of Accounts and notices thereof to Account Debtors. 
 Section 8.4. Nature of Remedies. Lender shall have the right to proceed against all or any portion of the Collateral to satisfy in any
order (a) the liabilities and Obligations of Borrower to Lender under this Agreement or (b) the liabilities and obligations of Borrower to Lender under the other Loan Documents. All rights and remedies granted Lender under this Agreement
and under any other Loan Document, or otherwise available at law or in equity, shall be deemed concurrent and cumulative, and not alternative remedies, and Lender may proceed with any number of remedies at the same time until the Loan, and all other
existing and future liabilities and obligations of Borrower to Lender, are satisfied in full. The exercise of any one right or remedy shall not be deemed a waiver or release of any other right or remedy, and Lender, upon the occurrence of an Event
of Default, may proceed against Borrower, and/or the Collateral, at any time, under any agreement, with any available remedy and in any order. All sums received from Borrower and/or the Collateral in respect of the Loan may be applied by Lender to
any other liabilities and obligations of Borrower under the Loan Documents in such order of application and in such amounts as Lender shall deem appropriate in its discretion. Borrower waives any right it may have to require Lender to pursue any
Person for any of the Obligations. 
  

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 Section 8.5. Waivers by Borrower. Except as otherwise provided for in this Agreement
and to the fullest extent permitted by applicable law, Borrower waives: (a) presentment, demand and protest, and notice of presentment, dishonor, intent to accelerate, acceleration, protest, default, nonpayment, maturity, release, compromise,
settlement, extension or renewal of any or all Loan Documents, the Notes or any other notes, commercial paper, Accounts, contracts, documents, instruments, chattel paper and guaranties at any time held by Lender on which Borrower may in any way be
liable, and hereby ratifies and confirms whatever Lender may do in this regard; (b) all rights to notice and a hearing prior to Lender’s taking possession or control of, or to Lender’s replevy, attachment or levy upon, any Collateral
or any bond or security that might be required by any court prior to allowing Lender to exercise any of its remedies; and (c) the benefit of all valuation, appraisal and exemption Laws. Borrower acknowledges that it has been advised by counsel
of its choices and decisions with respect to this Agreement, the other Loan Documents and the transactions evidenced hereby and thereby. 
 Section 8.6. Marshalling. Lender shall have no obligation to marshal any assets in favor of Borrower, or against or in payment of any of the other Obligations or any other obligation owed to Lender by Borrower.

 ARTICLE IX 
 MISCELLANEOUS 
 Section 9.1. Expenses and Taxes. 
 (a) Borrower agrees to pay, whether or not the Closing occurs, a reasonable documentation preparation fee, together with actual legal, audit and appraisal
fees and all other out-of-pocket charges and expenses (including reasonable attorneys’ fees) incurred by Lender in connection with the negotiation, preparation, legal review and execution of each of the Loan Documents, including but not limited
to UCC and judgment lien searches, title, litigation, tax and bankruptcy searches, title insurance policies, environmental insurance policies and UCC filings and fees for post-Closing UCC, title and other lien searches as specified in
Section 5.7. In addition, Borrower shall pay all such fees and expenses associated with any amendments, modifications and terminations to the Loan Documents following Closing. 
 (b) Borrower agrees to pay all fees and expenses incurred by Lender in connection with audits of Borrower’s books and records, audits and valuations
of Borrower’s inventory, appraisals of the Collateral and such other matters incident to the administration of the transactions contemplated by this Agreement as Lender shall deem appropriate. 
 (c) Borrower also agrees to pay all out-of-pocket charges and expenses incurred by Lender (including the court costs and fees and expenses of
Lender’s counsel, advisers and consultants) in connection with (i) the enforcement, protection or preservation of any right or claim of Lender, (ii) recording, filing and registration fees and charges, mortgage or documentary taxes,
UCC searches, title and survey charges, (iii) all fees and disbursements of Lender’s consultants, (iv) the termination of this Agreement, (v) the creation, preservation, perfection, maintenance, amendment and termination of any
Liens of Lender on the Collateral and (vi) the collection of any amounts due under the Loan Documents. 
 (d) If Lender uses in-house
counsel for any of the purposes set forth in (a), (b) or (c) above, Borrower agrees that its Obligations under the Loan Documents include reasonable charges for such work commensurate with the fees that would otherwise be charged by
outside legal counsel selected by Lender for the work performed. Borrower acknowledges that Lender may use both in–house and outside counsel for any of such purposes but Lender shall use reasonable efforts to avoid duplicate fees for the same
tasks. 
 (e) Borrower shall pay all taxes (other than taxes based upon or measured by Lender’s income or revenues or any personal
property tax), if any, in connection with the issuance of the Notes and the recording of any Loan Documents. The obligations of Borrower under this clause (e) shall survive the payment of Borrower’s indebtedness under this Agreement and
the termination of this Agreement. 
  

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 Section 9.2. My AccountSM. In consideration of being given access to and the right to use the MyAccount website and service of Lender, Borrower hereby agrees to the terms and conditions set forth on Exhibit F, attached hereto, as such may be
amended by Lender from time to time by posting revised terms and conditions on the MyAccount website. In the event Borrower elects not to utilize the MyAccount website to electronically submit a Borrowing Base Certificate to Lender in connection
with a request for an Advance, Lender will be entitled to assess a fee equal to Twenty Five Dollars ($25) for each such request. 
 Section 9.3. Judgment Currency. 
 (a) The obligations of any Borrower under this Agreement and the other Loan
Documents to make payments in US dollars (the “Obligation Currency”) shall not be discharged or satisfied by any tender or recovery pursuant to any judgment expressed in or converted into any currency other than the Obligation
Currency, except to the extent that such tender or recovery results in the effective receipt by the Lender of the full amount of the Obligation Currency expressed to be payable to the Lender under this Agreement or the other Loan Documents. If, for
the purpose of obtaining or enforcing a judgment against any Borrower in any court or in any jurisdiction, it becomes necessary to convert into or from any currency other than the Obligation Currency (such other currency, the “Judgment
Currency”) an amount due in the Obligation Currency, the conversion shall be made at the rate of exchange quoted by the Lender, determined, in each case, as of the business day immediately preceding the day on which the judgment is given
(such business day, the “Judgment Currency Conversion Date”). 
 (b) If there is a change in the rate of exchange prevailing
between the Judgment Currency Conversion Date and the date of actual payment of the amount due, Borrower covenants and agrees to pay, or cause to be paid, such additional amounts, if any (but in any event not a lesser amount), as may be necessary to
ensure that the amount paid in the Judgment Currency, when converted at the rate of exchange prevailing on the actual date of payment, will produce the amount of the Obligation Currency that could have been purchased with the amount of the Judgment
Currency stipulated in the judgment or judicial award at the rate of exchange prevailing on the Judgment Currency Conversion Date. 
 (c) For
purposes of determining any rate of exchange for this Section 9.3, such amounts shall include any premium and costs payable in connection with the purchase of the Obligation Currency. 
 Section 9.4. Entire Agreement; Amendments. This Agreement and the other Loan Documents constitute the full and entire understanding
and agreement among the parties with regard to their subject matter and supersede all prior written or oral agreements, understandings, representations and warranties made with respect thereto. No amendment, supplement or modification of this
Agreement nor any waiver of any provision thereof shall be made except in writing executed by the party against whom enforcement is sought. 
 Section 9.5. No Waiver; Cumulative Rights. No waiver by any party to this Agreement of any one or more defaults by the other party in the performance of any of the provisions of this Agreement shall operate or be
construed as a waiver of any future default or defaults, whether of a like or different nature. No failure or delay on the part of any party in exercising any right, power or remedy under this Agreement, nor acceptance of partial performance or
partial payment, shall operate as a waiver of such right, power or remedy nor shall any single or partial exercise of any such right, power or remedy preclude any other or further exercise of such right, power or remedy or the exercise of any other
right, power or remedy. The remedies provided for in this Agreement are cumulative and are not exclusive of any remedies that may be available to any party to this Agreement at law, in equity or otherwise. 
  

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 Section 9.6. Notices. Any notice or other communication required or permitted under
this Agreement shall be in writing and personally delivered, mailed by registered or certified mail (return receipt requested and postage prepaid), sent by telecopier (with a confirming copy sent by regular mail), or sent by prepaid overnight
courier service, and addressed to the relevant party at its address set forth below, or at such other address as such party may, by written notice, designate as its address for purposes of notice under this Agreement: 
  

									
		 	(a)	  	If to Lender, at:	 		 	
				
		 		  	General Electric Capital Corporation	 	
		 		  	2 Bethesda Metro Center, Suite 600	 		 	
		 		  	Bethesda, Maryland 20814-5318	 		 	
		 		  	Attention:          General Counsel	 		 	
		 		  	Telephone:        (301) 961-1640	 		 	
		 		  	Telecopier:        (301) 664-9866	 		 	
					
		 	(b)	  	If to Borrower, at:	 		 	
					
		 		  	NimbleGen Systems, Inc	 		 	
		 		  	One Science Court	 		 	
		 		  	Madison, Wisconsin 53711	 		 	
		 		  	Attention:          David Snyder (or other individual acting as Chief Financial Officer of NimbleGen Systems,
Inc.)
		 		  	Telephone:        (608) 218-7600	 		 	
		 		  	Telecopier:        (608) 218-7601	 		 	

 If mailed, notice shall be deemed to be given five (5) days after being sent, and if sent by personal
delivery, telecopier or prepaid courier, notice shall be deemed to be given when delivered. 
 Section 9.7. Severability.
If any term, covenant or condition of this Agreement, or the application of such term, covenant or condition to any party or circumstance, shall be found by a court of competent jurisdiction to be, to any extent, invalid or unenforceable, the
remainder of this Agreement and the application of such term, covenant, or condition to parties or circumstances other than those as to which it is held invalid or unenforceable shall not be affected thereby, and each term, covenant or condition
shall be valid and enforced to the fullest extent permitted by law. Upon determination that any such term is invalid, illegal or unenforceable, Lender may, but is not obligated to, advance funds to Borrower under this Agreement until the parties to
this Agreement amend this Agreement so as to effect the original intent of the parties as closely as possible in a valid and enforceable manner. 
 Section 9.8. Successors and Assigns. This Agreement, the Note, and the other Loan Documents shall be binding upon and inure to the benefit of Borrower and Lender and their respective successors and assigns and shall bind
all Persons who become bound as a debtor to this Agreement. Notwithstanding the foregoing, Borrower may not assign any of its rights or delegate any of its obligations under this Agreement without the prior written consent of Lender, which may be
withheld in Lender’s discretion. Lender may, from time to time, without the consent of Borrower, sell, transfer, pledge, assign and convey the Credit Facilities and the Loan Documents (or any interest therein) and may grant participations in
the Credit Facilities (it being acknowledged that any successor in interest to all or any interest in the Credit Facilities and the Loan Documents shall have all the rights of Lender hereunder) to any commercial bank or other financial institution,
or with the consent of Borrower, which consent shall not be unreasonably withheld, any other Person. Borrower agrees to cooperate with Lender’s efforts to do any of the foregoing and to execute all documents reasonably required by Lender in
connection therewith. 
 Section 9.9. Counterparts. This Agreement may be executed in any number of counterparts, each of
which shall be deemed an original, but all of which together shall constitute but one instrument. Facsimile signatures on this Agreement shall be treated for all purposes as binding on such signatory to the same extent as an original signature;
provided, however, if a party delivers an executed counterpart of this Agreement, such party shall deliver to the Lender (or its counsel) such number of original signatures of this Agreement promptly as requested by Lender after its
effectiveness. 
 Section 9.10. Survival of Terms. All covenants, agreements, representations and warranties made in this
Agreement, any other Loan Document, and in any certificates and other instruments delivered in connection with this Agreement shall be considered to have been relied upon by Lender and shall survive the making by Lender of the Credit Facilities
contemplated by this Agreement and the execution and delivery to Lender of the Note, and shall continue in full force and effect until all Obligations of Borrower to Lender are satisfied in full. All indemnity obligations of Borrower under any of
the Loan Documents shall survive the termination of 

  

 51 

 
such Loan Document. Borrower’s Obligations under this Agreement shall continue to be effective, and Borrower’s Obligations shall be reinstated, if
at any time payment of all or any part of the of the Obligations is rescinded or must otherwise be returned or restored by Lender upon the insolvency, bankruptcy, dissolution, liquidation or reorganization of Borrower or otherwise, all as though
such payment had not been made. 
 Section 9.11. Release of Lender. For and in consideration of the Loan and each advance
or other financial accommodation hereunder, Borrower voluntarily, knowingly, unconditionally, and irrevocably, with specific and express intent, for and on behalf of itself and its agents, attorneys, heirs, successors, and assigns (collectively the
“Releasing Parties”) does hereby fully and completely release, acquit and forever discharge Lender, and its successors, assigns, heirs, affiliates, subsidiaries, parent companies, principals, directors, officers, employees,
shareholders and agents (hereinafter called the “Lender Parties”), and any other person, firm, business, corporation, insurer, or association that may be responsible or liable for the acts or omissions of Lender Parties, or who may
be liable for the injury or damage resulting therefrom (collectively the “Released Parties”), of and from any and all actions, causes of action, suits, debts, disputes, damages, claims, obligations, liabilities, costs, expenses and
demands of any kind whatsoever, at law or in equity, whether matured or unmatured, liquidated or unliquidated, vested or contingent, choate or inchoate, known or unknown (“Claims”) that the Releasing Parties (or any of them) have or
may have, against the Released Parties or any of them (whether directly or indirectly); provided, however, no Released Party shall be released for Claims arising from such Released Party’s gross negligence or willful misconduct as
determined as a final judgment by a court of competent jurisdiction. Each Borrower acknowledges that the foregoing release is a material inducement to Lender’s decision to extend to Borrower the financial accommodations hereunder and has been
relied upon by Lender in agreeing to make the Loan and in making each advance of Loan proceeds hereunder. 
 Section 9.12.
Time. Whenever Borrower is required to make any payment or perform any act on a Saturday, Sunday, or a legal holiday under the laws of the State of New York (or other jurisdiction where Borrower is required to make the payment or perform
the act), the payment may be made or the act performed on the next Business Day. Time is of the essence in Borrower’s performance under this Agreement and all other Loan Documents. 
 Section 9.13. Commissions. Except as disclosed in the Information Certificate, the transaction contemplated by this Agreement was
brought about by Lender and Borrower acting as principals and without any brokers, agents, or finders being the effective procuring cause. Borrower represents that it has not committed Lender to the payment of any brokerage fee, commission, or
charge in connection with this transaction. If any such claim is made on Lender by any broker, finder, or agent or other person, Borrower will indemnify, defend, and hold Lender harmless from and against the claim and will defend any action to
recover on that claim, at Borrower’s cost and expense, including Lender’s counsel fees. Borrower further agrees that until any such claim or demand is adjudicated in Lender’s favor, the amount demanded will be deemed a liability of
Borrower under this Agreement, secured by the Collateral. 
 Section 9.14. Third Parties. No rights are intended to be
created under this Agreement or under any other Loan Document for the benefit of any third party donee, creditor, or incidental beneficiary of Borrower. Nothing contained in this Agreement shall be construed as a delegation to Lender of
Borrower’s duty of performance, including, without limitation, Borrower’s duties under any account or contract in which Lender has a security interest. 
 Section 9.15. Discharge of Borrower’s Obligations. Lender, in its discretion, shall have the right at any time, and from time to time, without prior notice to Borrower if Borrower fails to do
so in the manner required by this Agreement, to: (a) obtain insurance covering any of the Collateral as required under this Agreement; (b) pay for the performance of any of Borrower’s obligations under this Agreement;
(c) discharge taxes, Liens, security interests, or other encumbrances at any time levied or placed on any of the Collateral in violation of this Agreement unless Borrower is in good faith with due diligence by appropriate proceedings contesting
those items; and (d) pay for the maintenance and preservation of any of the Collateral. Expenses and advances shall be added to the outstanding balance of the Credit Facilities (to such Credit Facility as Lender shall elect) until reimbursed to
Lender and shall be secured by the Collateral and payable immediately upon demand of Lender. Any such payments and advances by Lender shall not be construed as a waiver by Lender of an Event of Default. 
  

 52 

 Section 9.16. Confidential Information. Borrower will not disclose any contents of
this Agreement or the other Loan Documents to any third party (including, without limitation, any financial institution or intermediary) without Lender’s prior written consent, other than to Borrower’s officers or directors on an
need-to-know basis. Borrower agrees to inform all such persons who receive information concerning this Agreement that such information is confidential and may not be disclosed to any other Person. 
 Section 9.17. Indemnity. Borrower hereby indemnifies and agrees to defend (with counsel acceptable to Lender) and hold harmless
Lender, its partners, officers, directors, attorneys, consultants, agents and employees (collectively, “Indemnitee”) from and against any liability, loss, cost, expense (including reasonable attorneys’ fees and expenses for
both in-house and outside counsel), claim, damage, suit, action or proceeding ever suffered or incurred by Lender or in which Lender may ever be or become involved (whether as a party, witness or otherwise) by reason of this Agreement, the other
Loan Documents or the transactions contemplated hereby or thereby; provided, that such indemnity shall not, as to any Indemnitee, be available to the extent that such losses, claims, damages, liabilities or related expenses are determined as
a final judgment by a court of competent jurisdiction to have resulted from the gross negligence or willful misconduct of such Indemnitee. Notwithstanding any contrary provision in this Agreement, the obligation of Borrower under this
Section 9.17 shall survive the payment in full of the Obligations and the termination of this Agreement. Borrower shall pay all obligations under this Section 9.17 immediately upon demand by Lender. Each such obligation shall
be added to, and considered to be part of, the principal of the Notes, and shall bear interest from the date the obligation arises at the highest interest rate then in effect. NO INDEMNITEE PERSON SHALL BE RESPONSIBLE OR LIABLE TO THE BORROWER OR TO
ANY OTHER PARTY TO ANY LOAN DOCUMENT, ANY SUCCESSOR, ASSIGNEE OR THIRD PARTY BENEFICIARY OR ANY OTHER PERSON ASSERTING CLAIMS DERIVATIVELY THROUGH SUCH PARTY, FOR INDIRECT, PUNITIVE, EXEMPLARY OR CONSEQUENTIAL DAMAGES (BUT NOT ACTUAL DAMAGES) WHICH
MAY BE ALLEGED AS A RESULT OF CREDIT HAVING BEEN EXTENDED, SUSPENDED OR TERMINATED UNDER THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT OR AS A RESULT OF ANY OTHER TRANSACTION CONTEMPLATED HEREUNDER OR THEREUNDER. 
 Section 9.18. Appointment of Lender under this Agreement. Each of the entities comprising Borrower hereby irrevocably appoints and
constitutes Borrower Agent as its agent to request and receive the proceeds of advances in respect of the Credit Facilities (and to otherwise act on behalf of each such entity pursuant to this Agreement and the other Loan Documents) from Lender in
the name or on behalf of each such entity. Lender may disburse such proceeds to the bank account of Borrower Agent without notice to any of the other entities comprising Borrower or any other Person at any time obligated on or in respect of the
Obligations. This authorization is coupled with an interest and shall be irrevocable, and Lender may rely on any notice, request, or information supplied by Borrower Agent, every document executed by Borrower Agent, every agreement made by Borrower
Agent or other action taken by Borrower Agent in respect of Borrower or any thereof as if the same were supplied, made or taken by any or all Borrower. No purported termination of the appointment of Borrower Agent as agent shall be effective without
the prior written consent of Lender. 
 Section 9.19. Lender Approvals. Unless expressly provided herein to the contrary,
any approval, consent, waiver or satisfaction of Lender with respect to any matter that is the subject of this Agreement or the other Loan Documents may be granted or withheld by Lender in its sole and absolute discretion and credit judgment.

 Section 9.20. Set-Offs. After the occurrence and during the continuance of an Event of Default, Borrower hereby
irrevocably authorizes and directs, Lender from time to time to charge Borrower’s accounts and deposits with Lender (or its Affiliates), and to pay over to Lender an amount equal to any amounts from time to time due and payable to Lender
hereunder, under the Notes or under any other Loan Document. 
 Section 9.21. Relationship. The relationship between
Lender and Borrower shall be that of creditor-debtor only. No term in this Agreement or in the other Loan Documents and no course of dealing between the parties shall be deemed to create any relationship of agency, partnership or joint venture or
any fiduciary duty by Lender to Borrower or any other party. 
  

 53 

 Section 9.22. Joint and Several Liability; Binding Obligations. Borrower is defined
collectively to include all Persons comprising Borrower and, as such, the terms of this Agreement are to be applied to each individual Person comprising Borrower (as well as to all such Persons taken as a whole); provided, however,
that any references herein to “any Borrower”, “each Borrower” or similar references, shall be construed as a reference to each individual Person comprising Borrower. This Agreement is a primary and original obligation of each
Person comprising Borrower and each Borrower shall be jointly and severally liable for all Obligations, existing and future, of any other Borrower as fully as if such Obligations were directly incurred by such Borrower under this Agreement,
regardless of which of Borrower actually receives the proceeds of the Loans or the benefit of any other extensions of credit hereunder, or the manner in which Borrower or Lender accounts therefor in their respective books and records. 
 Section 9.23. Choice of Law; Consent to Jurisdiction. WITH RESPECT TO ANY SUIT, ACTION OR PROCEEDINGS RELATING TO THIS AGREEMENT (EACH, A
“PROCEEDING”), BORROWER IRREVOCABLY (A) SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS HAVING JURISDICTION IN THE CITY, COUNTY AND STATE OF NEW YORK, AND (B) WAIVES ANY OBJECTION THAT IT MAY HAVE AT ANY
TIME TO THE LAYING OF VENUE OF ANY PROCEEDING BROUGHT IN ANY SUCH COURT, WAIVES ANY CLAIM THAT ANY PROCEEDING HAS BEEN BROUGHT IN AN INCONVENIENT FORUM AND FURTHER WAIVES THE RIGHT TO OBJECT, WITH RESPECT TO SUCH PROCEEDING, THAT SUCH COURT DOES NOT
HAVE JURISDICTION OVER SUCH PARTY. NOTHING IN THIS AGREEMENT SHALL PRECLUDE LENDER FROM BRINGING A PROCEEDING IN ANY OTHER JURISDICTION NOR WILL THE BRINGING OF A PROCEEDING IN ANY ONE OR MORE JURISDICTIONS PRECLUDE THE BRINGING OF A PROCEEDING IN
ANY OTHER JURISDICTION. BORROWER HEREBY WAIVES PERSONAL SERVICE OF ANY AND ALL PROCESS AND FURTHER AGREES AND CONSENTS THAT, IN ADDITION TO ANY METHODS OF SERVICE OF PROCESS PROVIDED FOR UNDER APPLICABLE LAW, ALL SERVICE OR PROCESS IN ANY PROCEEDING
IN ANY NEW YORK STATE OR UNITED STATES COURT SITTING IN THE CITY AND COUNTY OF NEW YORK MAY BE MADE BY CERTIFIED OR REGISTERED MAIL, RETURN RECEIPT REQUESTED, DIRECTED TO BORROWER AT THE ADDRESS INDICATED HEREIN, AND SERVICE SO MADE SHALL BE
COMPLETE UPON RECEIPT; EXCEPT THAT IF BORROWER SHALL REFUSE TO ACCEPT DELIVERY, SERVICE SHALL BE DEEMED COMPLETE FIVE (5) DAYS AFTER THE SAME SHALL HAVE BEEN SO MAILED. THIS AGREEMENT AND ALL RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER
SHALL BE GOVERNED BY AND BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO ANY PRINCIPLES OF LAW THAT WOULD REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER STATE. 
 Section 9.24. Waiver of Trial By Jury. WITH RESPECT TO ANY CLAIMS OR DISPUTES PERTAINING TO THIS AGREEMENT OR ANY OF THE OTHER LOAN
DOCUMENTS OR TO ANY MATTER ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENTS, BORROWER HEREBY (A) COVENANTS AND AGREES NOT TO ELECT A TRIAL BY JURY OF ANY ISSUE TRIABLE OF RIGHT BY A JURY, AND (B) WAIVES ANY RIGHT TO
TRIAL BY JURY FULLY TO THE EXTENT THAT ANY SUCH RIGHT SHALL NOW OR HEREAFTER EXIST. THIS WAIVER OF RIGHT TO TRIAL BY JURY IS SEPARATELY GIVEN, KNOWINGLY AND VOLUNTARILY, BY BORROWER, AND THIS WAIVER IS INTENDED TO ENCOMPASS INDIVIDUALLY EACH
INSTANCE AND EACH ISSUE AS TO WHICH THE RIGHT TO A JURY TRIAL WOULD OTHERWISE ACCRUE. LENDER IS HEREBY AUTHORIZED AND REQUESTED TO SUBMIT THIS AGREEMENT TO ANY COURT HAVING JURISDICTION OVER THE SUBJECT MATTER AND THE PARTIES TO THIS AGREEMENT, SO
AS TO SERVE AS CONCLUSIVE EVIDENCE OF BORROWER’S WAIVER OF THE RIGHT TO JURY TRIAL. FURTHER, BORROWER HEREBY CERTIFIES THAT NO REPRESENTATIVE OR AGENT OF LENDER (INCLUDING LENDER’S COUNSEL) HAS REPRESENTED, EXPRESSLY OR OTHERWISE, TO
BORROWER THAT LENDER WILL NOT SEEK TO ENFORCE THIS WAIVER OF RIGHT TO JURY TRIAL PROVISION. 
 Section 9.25. Existing
Agreements Superseded; Exhibits and Schedules. (a) The Original Loan Agreement, including the schedules thereto, is superseded by this Agreement (including the schedules hereto), which has been executed in renewal, amendment,

  

 54 

 
restatement and modification of, but not in novation or extinguishment of, the obligations under the Original Loan Agreement. Any and all outstanding amounts
under the Original Loan Agreement including, but not limited to principal, accrued interest, fees and other charges, as of the date hereof shall be carried over and deemed outstanding under this Agreement. 
 (b) Each Borrower reaffirms its obligations under every Loan Document to which it is a party, including but not limited to the Notes, the Pledge
Agreement, the Warrant and any schedules thereto, as applicable. 
 (c) Each Borrower agrees that each Loan Document (other than this
Agreement) to which it is a party shall remain in full force and effect following the execution and delivery of this Agreement and that all references in any of the Loan Documents to the “Loan Agreement” shall be deemed to refer to this
Amended and Restated Loan Agreement. 
 [SIGNATURES FOLLOW] 
  

 55 

 IN WITNESS WHEREOF, intending to be legally bound, and intending that this Agreement constitutes
an instrument executed under seal, the parties have caused this Agreement to be executed under seal as of the date first written above. 
  

							
	 BORROWER:
	 	NIMBLEGEN SYSTEMS INC., a Delaware corporation
			
		 	 By:
	 	 /s/ David S. Snyder

		 	 Name:
	 	David S. Snyder
		 	 Title:
	 	Vice President
		 	 Borrower’s Tax ID No. 39-2003768

  

							
		
		 	 NIMBLEGEN SYSTEMS OF ICELAND, LLC, 
 a Delaware limited liability company 

		 		 	By:	 	 NIMBLEGEN SYSTEMS INC., its sole member

				
		 		 	 By:
	 	 /s/ David S. Snyder

		 		 	 Name:
	 	David S. Snyder
		 		 	 Title:
	 	Vice President

					
	 LENDER:
	 	GENERAL ELECTRIC CAPITAL CORPORATION,
		 	a Delaware corporation
			
		 	By:	 	 /s/ Dave Earle

		 	Name:	 	Dave Earle
		 	Title:	 	Duly Authorized Signatory
			
		 	By:	 	 /s/ Scott R. Towers

		 	Name:	 	Scott R. Towers
		 	Title:	 	Duly Authorized Signatory

 EXHIBIT A 
 FINANCIAL COVENANTS AND CONDITIONS 
 (a) Definitions. As used herein, the following
terms have the following meanings (other capitalized terms used but not otherwise defined in this Exhibit A shall have the meanings given such terms in the Loan Agreement; such accounting terms used but not otherwise defined in this
Exhibit A shall have the meanings given such terms by GAAP): 
 “Balance Sheet Cash” means, as at the date of
determination, the amount of cash on hand plus cash on deposit as shown on the consolidated balance sheet of Borrower in accordance with GAAP. 
 “Capital Expenditures” means, for the applicable period, the aggregate of all expenditures (whether paid in cash or accrued as liabilities during such period and excluding that portion of any capital leases (except any cash
down payment) which is capitalized on the consolidated balance sheet of Borrower), net of cash amounts received by Borrower from other Persons during such period in reimbursement of Capital Expenditures made by Borrower, excluding interest
capitalized during construction by Borrower during such period, that, in conformity with GAAP, are required to be included in or reflected by the property, plant, equipment or intangibles or similar fixed asset accounts reflected in the consolidated
balance sheet of Borrower (including equipment that is purchased simultaneously with the trade-in of existing equipment owned by Borrower to the extent of the gross amount of such purchase price less the book value of the equipment being traded in
at such time), but excluding expenditures made in connection with the replacement or restoration of assets, to the extent reimbursed or financed from insurance proceeds paid on account of the loss of or the damage to the assets being replaced or
restored. 
 “EBITDA” means, for any twelve (12) month period on a trailing basis, without duplication, the total of
the following, all of which shall be determined by Lender in its discretion consistent with past practice: (i) net income determined in accordance with GAAP, plus (ii) to the extent included in the calculation of net income, the sum of
(A) income taxes paid or accrued (excluding any amounts Borrower includes in its sales, general and administrative expenses), (B) interest expenses, net of interest income, paid or accrued, (C) amortization and depreciation, and
(D) other non-cash charges (excluding accruals for cash expenses made in the ordinary course of business), less (iii) to the extent included in the calculation of net income, the sum of (X) the income of any Person in which Borrower
has a direct or indirect ownership interest, except to the extent such income is received by Borrower in a cash distribution during such period, (Y) gains or losses from sales or other dispositions of assets (other than inventory in the normal
course of business), and (Z) extraordinary or non-recurring gains and non-recurring losses. 
 “Fixed Charge Coverage
Ratio” means, for any twelve (12) month period on a trailing basis, the ratio of: (i) EBITDA less Capital Expenditures and less taxes paid in cash, to (ii) regularly scheduled payments of principal owed on
Indebtedness of Borrower (including, without limitation, the Loans) plus any interest on Indebtedness of Borrower (including, without limitation, the Loans) paid in cash. 
 “Operating Cash Requirements” means, as at any date of determination, EBITDA for the last full month immediately preceding such date of determination less (i) Capital Expenditures less
(ii) interest expense less (iii) scheduled principal payments, in each case, paid in cash during such month. 
 (b)
Covenants. Borrower shall maintain the following financial covenants, in each case measured as of the last day of the most recent month immediately preceding the initial advance under the Revolving Credit Facility for which financial
statements were required to be delivered, and on the last day of each calendar month thereafter, on a consolidated basis during the term of the Credit Facilities: 
 (i) For each calendar month in which Borrower’s Operating Cash Requirements is greater than or equal to $0, Borrower shall not allow its Fixed Charge Coverage Ratio to fall below a ratio of 1.0 to 1.0; or

 (ii) for each calendar month in which Borrower’s Operating Cash Requirements is less than $0, Balance Sheet Cash shall be greater
than the product of negative six (-6) times Operating Cash Requirements. 
  

 A-1 

 EXHIBIT B 
 NimbleGen Projections 
 [*] 
  

 B-1 

 EXHIBIT C 
 INSURANCE REQUIREMENTS 
 (See Attached) 
  

									
	 ACORD                    CERTIFICATE OF LIABILITY INSURANCE
	  	 OP ID BD
 NIMBL-1 
	  	DATE (06/29/06)

							
		
	 PRODUCER
  
 Johnson Insurance – Madison
 525 Junction Road
 Madison WI 53717
 Phone: 608-245-6580 Fax: 262-619-2805
	  	THIS CERTIFICATE IS ISSUED AS A MATTER OF INFORMATION ONLY AND CONFERS NO RIGHT UPON THE CERTIFICATE HOLDER. THIS CERTIFICATE DOES NOT AMEND, EXTEND OR ALTER THE COVERAGE AFFORDED
BY THE POLICIES BELOW.
	  	INSURERS AFFORDING COVERAGE	  	NAIC #

									
				
	INSURED	  	 Nimblegen Systems, Inc.
 NimbleGen Systems of Iceland,
LLC; and
 NimbleGen Systems, GmbH
 Rick
Sauer
 1 Science Court
 Madison WI 53711
	  	 INSURER A: St. Paul Fire & Marine Ins Co
 INSURER B:
 INSURER C:
 INSURER D:
 INSURER E:
	  	24767

 COVERAGES 
  

															
	 THE POLICIES OF
INSURANCE LISTED BELOW HAVE BEEN ISSUED TO THE INSURED NAMED ABOVE
FOR THE POLICY PERIOD INDICATED,
NOTWITHSTANDING ANY REQUIREMENT, TERM OR
CONDITION OF ANY CONTRACT OR OTHER DOCUMENT WITH RESPECT TO WHICH
THIS
CERTIFICATE MAY BE ISSUED OR MAY PERTAIN, THE INSURANCE AFFORDED
BY THE POLICIES DESCRIBED HEREIN IS SUBJECT TO ALL THE
TERMS,
EXCLUSIONS AND CONDITIONS OF SUCH POLICIES, AGGREGATE LIMITS SHOWN MAY HAVE
BEEN REDUCED BY PAID CLAIMS.

	 INS
LTR
	  	ADDL
INSRD	  	 TYPE OF
INSURANCE
	  	POLICY
NUMBER	  	POLICY EFFECTIVE
DATE
(MM/DD/YY)	  	POLICY EXPIRATION
DATE
(MM/DD/YY)	  	 LIMITS

	A	  	X	  	 GENERAL LIABILITY
 X COMMERCIAL GENERAL LIABILITY
      CLAIMS MADE X OCCUR
 
                                        
            
 
                                        
            
 GENL AGGREGATE LIMIT
APPLIES PER
          POLICY          PROJECT
          LOC
	  	TE06304789	  	04/15/06	  	04/15/07	  	 EACH OCCURRENCE
 
                                    
 DAMAGE TO RENTED

 PREMISES (EA
OCCURRENCE)
 
                                    
 MED EXP (ANY ONE
PERSON)
 
                                    
 PERSONAL & ADV
INJURY
 
                                    
 GENERAL AGGREGATE
 
                                    
 PRODUCTS – COMP/OP
AGG
	  	 $ 1000000
  
  
 $ 250000
  
  
 $ 10000
  
  
 $1000000
  
  
 $ 2000000
  
 $ 2000000

		  		  	 AUTOMOBILE LIABILITY
          ANY AUTO
          ALL OWNED AUTOS
          SCHEDULED AUTOS
          HIRED AUTOS
          NON-OWNED AUTOS
 
                                        
    
	  		  		  		  	 COMBINED SINGLE
LIMIT (EA ACCIDENT)
 
                                    
 BODILY INJURY (PER
PERSON)
 
                                    
 BODILY INJURY (PER
ACCIDENT)
 
                                    
 PROPERTY DAMAGE
(PER ACCIDENT)
	  	 $                         
  

 
 $
                        
  
  
 $
                        

		  		  	 GARAGE LIABILITY
          ANY AUTO
	  		  		  		  	 AUTO ONLY – EA
ACCIDENT
 
                                    
 OTHER THAN AUTO
ONLY: EA, ACC

 AGG
	  	 $
                        
  
  
 $
                        
 $
                        

		  		  	 EXCESS/UMBRELLA LIABILITY
          OCCUR          CLAIMS MADE
          DEDUCTIBLE
          RETENTION $
	  		  		  		  	 EACH OCCURRENCE
 
                                    
 AGGREGATE
 
                                    
 
                                    
 
                                    
	  	  
 $
                        
  
 $                         
 $                         
 $
                        

		  		  	 WORKERS COMPENSATION AND EMPLOYERS LIABILITY
  
 ANY PROPRIETOR/ PARTNER/ EXECUTIVE
OFFICER/MEM-
 BER EXCLUDED?
  
 IF YES, DESCRIBE UNDER
SPECIAL PROVISIONS BELOW
	  		  		  		  	 WC STATUTORY LIMITS
                                      
 E.L. EACH ACCIDENT
 
                                    
 E.L. DISEASES – EA
EMPLOYEE
                                      
 E.L. DISEASE – POLICY
LIMIT
	  	  
 $
                        
  
 $                         
  
  
 $
                        
  
 $
                        

	A	  		  	 OTHER
 Property Section
	  	TE06304789	  	04/15/06	  	04/15/07	  	 ICELAND
 
                                    
 GERMANY
	  	 $ 4000000
  
 $ 300000

	
	 DESCRIPTION OF OPERATIONS /
LOCATIONS / VEHICLES / EXCLUSIONS ADDED BY ENDORSEMENT / SPECIAL PROVISIONS
 International Package Coverage with regard to Vinlandsleio 2-4 Reykjavik 113 Iceland and Beuthenerstr. 2 Waldkraiburg Germany D-84478. General Electric Capital Corp is
Additional Insured with regard to Liability and Lender Loss Payee with regard to Property.

	 CERTIFICATE HOLDER
	  	CANCELLATION
	 GENELE3
 General
Electric Capital Corp.
 2 Bethesda Metro Ctr Ste 600
 Bethesda MD
20814-5318
	  	SHOULD ANY OF THE ABOVE DESCRIBED POLICIES BE
CANCELLED BEFORE
THE EXPIRATION DATE THEREOF, THE ISSUING INSURER WILL ENDEAVOR
TO
MAIL          DAYS WRITTEN NOTICE TO THE CERTIFICATE HOLDER
NAMED TO
THE LEFT, BUT FAILURE TO DO SO SHALL IMPOSE NO
OBLIGATION OR
LIABILITY OF ANY KIND UPON THE INSURER, ITS AGENTS
OR
REPRESENTATIVES.
		  	AUTHORIZED REPRESENTATIVE  
 /s/
PATRICK R. KELLY

  

									
	 ACORD
	  	EVIDENCE OF PROPERTY INSURANCE	  	Date (06/29/06)
	
	THIS IS EVIDENCE THAT INSURANCE AS IDENTIFIED BELOW
HAS BEEN ISSUED, IS IN FORCE, AND CONVEYS ALL THE RIGHTS AND
PRIVILEGES AFFORDED UNDER THE POLICY.
		
	 PRODUCER     Phone / Fax 608-245-6580 262-619-2805

 
 Johnson Insurance – Madison
 525 Junction Road
 Madison WI 53717
 Patrick Kelly
	  	 COMPANY
  
 St. Paul Fire & Marine Ins Co
 20800 Swenson Dr. Ste 300
 Waukesha WI 53186-4057

	 CODE:
	  	 SUB CODE:
	  		  		  	
				
	AGENCY CUSTOMER ID #: NIMBL-1	  		  		  	
			
	 INSURED
  
 NimbleGen Systems, Inc.
 Rick Sauer
 1 Science Court
 Madison WI 53711
	  	LOAN NUMBER	  	POLICY NUMBER TE06304789
	  	 EFFECTIVE DATE
  
  
 04/15/06
	  	EXPIRATION DATE 04/15/07
	  	         CONTINUED
UNTIL TERMINATED
IF CHECKED
			
		  		  	THIS REPLACES PRIOR EVIDENCE DATED:
	
	 PROPERTY INFORMATION
  

	
	 LOCATION/DESCRIPTION
 001
  
 Vinlandsleio 2-4
 Reykjavik 113 Iceland

	
	 COVERAGE INFORMATION

	COVERAGE/PERILS/FORMS	  	AMOUNT OF INSURANCE	  	DEDUCTIBLE
			
	 Premise 1 Building 1 – Vinlandslei 2-4, 113 Reykjavik, Iceland Personal Property
	  	400000	  	1000
			
	 Premise 2 Building 1 – Beuthenerstr. 2, Waldkraiburg, Germany D-84478 Personal
Property
	  	300000	  	1000
	
	 REMARKS including special conditions

	
	 Named insured includes NimbleGen Systems of Iceland, LLC and Nimblegen Systems, GmbH.

					
	 CANCELLATION
	  		  		  		  	
	
	THE POLICY IS SUBJECT TO THE PREMIUMS, FORMS,
AND RULES IN EFFECT FOR EACH POLICY PERIOD. SHOULD THE POLICY BE
TERMINATED, THE COMPANY WILL GIVE THE ADDITIONAL INTEREST IDENTIFIED BELOW
         DAYS WRITTEN NOTICE, AND WILL SEND NOTIFICATION OF ANY
CHANGES TO THE POLICY THAT WOULD AFFECT THAT INTEREST, IN ACCORDANCE
WITH THE POLICY PROVISIONS OR AS REQUIRED BY LAW.
	
	 ADDITIONAL INTEREST

	
	 NAME AND ADDRESS

			
	 General Electric Capital Corp.
 2 Bethesda Metro Ctr, Ste 600
 Bethesda MD 20814-5318
	  	         MORTGAGE	  	         ADDITIONAL
INSURED
	  	         LOSS PAYEE	  	
	  		  	  X   Lender Loss Payee
	  	  
 LOAN #

	  	  
 AUTHORIZED REPRESENTATIVE
  
 /S/ PATRICK R. KELLY

			
	 ACORD                 EVIDENCE OF PROPERTY INSURANCE
SCHEDULE
 Nimblegen Systems,
Inc.                NIMBL-1
	  	 DATE (06/29/06)
 PAGE 2

	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION 002
  
 Beuthenerstr. 2
 Waldkraiburg, Germany D-84478
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	
		
	 PROPERTY INFORMATION
  
 LOCATION/DESCRIPTION
	  	

  

 EXHIBIT D 
 POST-CLOSING OBLIGATIONS 
 (a) On or before the initial draw under the Revolving Facility,
Borrower shall deliver to Lender a fully executed Landlord’s Waiver and Consent, in form and substance substantially similar to the Landlord’s Waiver and Consent, attached hereto as Exhibit E, from Borrower’s landlord regarding
the premises located at Snorrabraut 60, 105 Reykjavik, Iceland; provided that prior to the initial draw under the Revolving Facility, Borrower must continue to diligently, continuously and in good faith pursue such Landlord’s Waiver and
Consent or seek a waiver of this condition in accordance with the terms of the Loan Agreement. 
 (b) On or before a date that is forty-five
(45) days following the Restatement Date, Borrower shall deliver that certain Warrant to Purchase 30,000 shares of Series F Preferred Stock, in form and substance substantially similar to the Outstanding Warrant or as is otherwise reasonably
acceptable to Lender. 
 (c) On or before a date that is thirty (30) days following the Restatement Date, Borrower shall deliver copies
of all material agreements, notes, consulting agreement and other documents set forth on the Information Certificate dated as of the Restatement Date that had not been disclosed on the Information Certificate dated as of the Closing Date and as
Lender may request, it being understood that such disclosure and delivery shall not cure any default related to such material agreements, notes, consulting agreement or other documents and provided that Lender shall execute and deliver such
confidentiality agreement(s), if any, as are required in order that Borrower may make disclosure of the same without breach of or default thereunder. 
 The failure of Borrower to deliver the foregoing items on the schedules set forth above shall constitute an “Event of Default” under the Section 8.1(c) of the Loan Agreement. 
  

 D-1 

 EXHIBIT E 
 LANDLORD’S WAIVER AND CONSENT 
 THIS LANDLORD’S WAIVER AND CONSENT (“Waiver and
Consent”), dated as of                          _, 200    , by and among
[    landlord’s name     ] (“Landlord”), [    tenant’s name    ]
(“Tenant”) and General Electric Capital Corporation, a Delaware corporation (together with its successors and assigns, collectively, “Lender”), is entered into pursuant to certain requirements under that certain
Loan and Security Agreement, dated as of May     , 2006 (as amended, modified, restated or replaced from time to time, the “Loan Agreement”). 
 RECITALS 
 A. Landlord is the owner of the real property located at
                            , as more particularly described in Appendix A attached hereto (the
“Premises”). 
 B. Landlord has entered into that certain [Lease Agreement], dated as of
                         , 200     (together with all amendments and modifications
thereto and waivers thereof, the “Lease”), with Tenant pursuant to which Tenant has acquired a leasehold interest in all or a portion of the Premises. 
 C. Tenant and certain of its subsidiaries and affiliates (collectively, “Borrower”) and Lender have entered into the Loan Agreement pursuant to which Borrower agreed to grant to Lender a security
interest in and lien upon substantially all of the tangible and intangible property of Borrower, including, without limitation, all of Borrower’s accounts, cash, cash equivalents, goods, inventory, machinery, equipment, furniture and fixtures,
and all books, records, invoices and other documents related to such tangible and intangible property, together with all additions, substitutions, replacements and improvements to, and proceeds of, the foregoing (collectively, the
“Collateral”). 
 NOW THEREFORE, for and in consideration of the facts mentioned above, the mutual promises set forth below and other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree as follows: 
 1. Landlord acknowledges that
(a) a true and correct copy of the Lease as in effect as of the date hereof is attached hereto as Appendix B, (b) the Lease is in full force and effect and (c) Landlord is not aware of any existing default under the Lease.

 2. Landlord represents that it is the holder of the interests of Landlord under the Lease and has full right and authority to enter into this Agreement.

 3. Landlord agrees to provide Lender with (a) a copy of any cancellation, amendment, consent, or waiver under the Lease, and (b) written notice
of any default or claimed default of Tenant under the Lease (a “Default Notice”) at the same time as it sends such notice to Tenant; provided, that (i) Lender shall have at least 15 days following receipt of such Default
Notice to cure such default before the Lease terminates, and (ii) Lender shall not be under any obligation to cure any default by Tenant under the Lease. No action by Lender pursuant to this Waiver and Consent shall constitute or be deemed to
be an assumption by Lender of any obligation under the Lease, and, except as provided in paragraphs 7 and 8 below, Lender shall not have any obligation to Landlord. 
 4. Landlord acknowledges the validity of Lender’s lien on the Collateral and, until such time as the obligations of the Tenant to Lender are indefeasibly paid in full and any further obligation of Lender to
extend any credit to Borrower under the Loan Documents is terminated, Landlord waives any interest in the Collateral, statutory or otherwise, and agrees not to distrain or levy upon any Collateral or to assert any landlord lien, right of distraint
or other claim against the Collateral for any reason. 
  

 E-1 

 5. Landlord agrees that the Collateral may be stored, utilized, and/or installed at the Premises and shall not be deemed
a fixture or part of the real estate but shall at all times be considered personal property, whether or not any Collateral becomes so related to the real estate that an interest therein would otherwise arise under applicable law. 
 6. Prior to a termination of the Lease, Lender or its representatives or invitees may enter upon the Premises at any time without any interference by Landlord to
inspect, repossess, remove and/or otherwise deal with the Collateral. 
 7. Upon a termination of the Lease, Landlord will permit Lender and its
representatives and invitees to exclusively occupy and remain on the Premises; provided, that (a) such period of occupation (the “Disposition Period”) shall not exceed 150 days following receipt by Lender of a Default
Notice or, if the Lease has expired by its own terms (absent a default thereunder), up to 30 days following Lender’s receipt of written notice of such expiration, (b) for the actual period of occupancy by Lender, Lender will pay to
Landlord the basic rent due under the Lease pro-rated on a per diem basis determined based on a 30-day month, and shall provide and retain liability and property insurance coverage, electricity and heat to the extent required by the Lease, and
(c) such amounts paid by Lender to Landlord shall exclude any rent adjustments, indemnity payments or similar amounts payable under the Lease for default, holdover status or other similar charges. 
 8. During any Disposition Period, (a) Lender and its representatives and invitees may inspect, repossess, remove and/or otherwise deal with the Collateral, and may
advertise and conduct public auctions or private sales of the Collateral at the Premises, in each case, without interference by Landlord or liability of Lender to Landlord, and (b) Lender shall make the Premises available for inspection by
Landlord and prospective tenants and shall cooperate in Landlord’s reasonable efforts to re-lease the Premises. Lender shall promptly repair, at Lender’s expense, any physical damage to the Premises actually caused by the removal of
Collateral by or through Lender (ordinary wear and tear excluded). Lender shall not be liable for any diminution in value of the Premises caused by the absence of Collateral actually removed or by any necessity of replacing the Collateral, and
Lender shall have no duty or obligation to remove or dispose of any Collateral or any other property left on the Premises by Tenant. 
 9. If any order or
injunction is issued or stay granted which prohibits Lender from exercising any of its rights hereunder, then, at Lender’s option, the Disposition Period shall be extended for the period of such prohibition and shall continue thereafter for the
greater of (a) the number of days remaining in the Disposition Period or (b) 90 days. 
 10. All notices hereunder shall be in writing, sent by
certified mail, return receipt requested, to the respective parties and the following addresses: 
  

			
	 Lender:
	  	
		  	General Electric Capital Corporation
		  	Two Bethesda Metro Center, Suite 600
		  	Bethesda, MD 20814-5318
		  	Attention: General Counsel
		  	Telecopier No. (301) 961-1640
		  	Telephone No. (301) 664-9866
		
	 Tenant:
	  	
		  	NimbleGen Systems, Inc.
		  	One Science Court
		  	Madison, WI 53711

  

 E-2 

			
		  	 Attention:

		  	 Telephone: (    )

		  	 Facsimile: (    )

	 Landlord:
	  	

 11. This Waiver and Consent may be executed in any number of several counterparts, shall be governed and
controlled by, and interpreted under, the laws of the State of                             , and shall
inure to the benefit of Lender and its successors and assigns and shall be binding upon Landlord and its successors and assigns (including any transferees of the Premises). 
 [Signature Page Follows] 
  

 E-3 

 IN WITNESS WHEREOF, this Landlord’s Waiver and Consent is entered into as of the date first set forth above.

  

			
	 “Landlord”

	
	 [LANDLORD]

		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	 “Tenant”

	
	 [TENANT]

		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	“Lender”
	
	GENERAL ELECTRIC CAPITAL CORPORATION
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  

 E-4 

 EXHIBIT F 
 Terms and Conditions 
 of 
 MyAccountSM Usage 
 (Disclosure Schedule) 
 The MyAccount service is an electronic service provided by Lender and its affiliates, which (a) provides Borrower with electronic access via the
World Wide Web to information regarding its loan account(s) under the Loan Agreement through the use of web browsers and (b) allows Borrower to electronically submit Borrowing Base Certificates to Lender in connection with requests for
Revolving Credit Loans. By accessing and/or using the MyAccount service, Borrower agrees to accept and abide by the following terms and conditions as well as the Privacy Policy posted on the MyAccount site (the “Privacy
Policy”) for each use and access of this service. 
 1. CHANGES TO TERMS AND CONDITIONS: Lender reserves the right, at
its sole discretion, to change, modify, add or remove any portion of these Terms and Conditions, including the Privacy Policy, in whole or in part, at any time. Notification of changes in these Terms and Conditions and/or the Privacy Policy will be
posted on the MyAccount site. Changes in these Terms and Conditions will be effective when notice of such changes has been posted. Borrower’s continued use of the MyAccount site after such changes are posted will constitute its agreement to
such changed Terms and Conditions and/or the Privacy Policy. 
 2. CHANGES TO SERVICE AND TERMINATE ACCESS: Lender may change, modify,
remove, suspend terminate or discontinue any aspect of the MyAccount site or service at any time without notice or liability. Lender, in its sole discretion, may also impose limits or restrictions on certain services, features or content, terminate
Borrower’s access to parts or all of the MyAccount site or service and terminate all rights and licenses contained in these Terms and Conditions without notice or liability. 
 3. PASSWORDS: Lender will issue to Borrower a user name, password or other access codes or security items (collectively,
“Passwords”). Borrower will be solely responsible for the use and proper protection of the Passwords. Borrower agrees to take all reasonable precautions to protect the security and integrity of the Passwords and to prevent their
unauthorized use. The MyAccount service is a private computer system. Access to the MyAccount service is restricted to those who have Passwords. Borrower’s Passwords should never be shared with anyone and Borrower may not allow anyone other
than an authorized officer of Borrower to use them. Borrower will be solely responsible for all actions taken that use its Passwords, including all transmissions by Borrower of electronic records and electronic signatures, other than actions
involving the unauthorized use of such Passwords by Lender and/or its affiliates. “Electronic records” refer to a record or information created, generated, sent, communicated, received or stored electronically, such as Borrower’s
financial data and Borrowing Base Certificates in connection with requests for Revolving Credit Loans. Borrower will immediately notify Lender in writing if Borrower becomes aware of any unauthorized access or use of its Passwords and/or the
MyAccount service, or if Borrower’s Passwords are lost or stolen. Such notice shall not release Borrower from responsibility for such loss, theft, unauthorized access or use of its Passwords and/or the MyAccount service, or any other losses
that may be incurred by Lender. Lender shall be entitled to assess Borrower’s Passwords and, if Lender determines that Borrower is using Passwords that Lender considers insecure, Lender may at its discretion require Borrower to change the
Passwords and/or terminate Borrower’s account. 
 Borrower shall be prohibited from using any services or facilities provided in
connection with the MyAccount site to compromise its security or tamper with system resources and/or accounts. The use or distribution of tools designed for compromising security (e.g., password guessing programs, cracking tools or network probing
tools) is strictly prohibited. If Borrower become involved in any violation of system security, Lender reserves the right to release Borrower’s details to system administrators at other websites in order to assist them in resolving security
incidents. Lender reserves the right to investigate suspected violations of these Terms and Conditions. 
 Lender reserves the right to fully
cooperate with any law enforcement authorities, or comply with any court order or subpoena 

  

 F-1 

 
requesting or directing Lender to disclose any information concerning a user or registered user of the MyAccount site. BY ACCEPTING THESE TERMS AND
CONDITIONS BORROWER WAIVES AND HOLDS HARMLESS LENDER FROM ANY CLAIMS RESULTING FROM ANY ACTION TAKEN BY LENDER DURING OR AS A RESULT OF ITS INVESTIGATIONS AND/OR FROM ANY ACTIONS TAKEN AS A CONSEQUENCE OF INVESTIGATIONS BY EITHER LENDER OR LAW
ENFORCEMENT AUTHORITIES. 
 4. CONSENT TO ELECTRONIC TRANSACTIONS: At the
MyAccount site, Borrower may transmit and receive electronic records relating to its financial condition, the Loans or the Collateral and allow Lender to compute the Borrowing Base, availability within the Borrowing Base and other related
calculations using electronic records and other information provided by Borrower in lieu of submitting such information in writing and signed by an authorized officer of Borrower. Borrower’s affirmative actions in using the MyAccount site, such
as clicking “I Accept”, “Submit”, “Yes”, “Go” and the like and uploading of data to Lender, signify that Borrower agrees to, adopts and executes the action or electronic record with the intention to be legally
bound, and the words “execution”, “signed”, “signature”, and words of like import in any Borrowing Base certificate given to Lender in connection with a request for a Revolving Credit Loan shall be deemed to be
satisfied by such affirmative actions. Such affirmative actions will have the same legal force, effect, validity and enforceability as if an authorized officer of Borrower affixed a written signature to the electronic record, and such electronic
signature and electronic record shall be deemed to satisfy the writing and delivery requirements of any applicable law, to the extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National
Commerce Act, the Maryland Uniform Electronic Transactions Act, or any other similar state laws based on the Uniform Electronic Transactions Act. Borrower agrees to transmit and receive electronic records through the MyAccount service via the
Internet using its Passwords. Lender’s electronic or other properly stored copy of such electronic signatures and electronic records shall be deemed to be the true, complete, valid, authentic and enforceable copy of them. Borrower will not
transmit to Lender via the MyAccount site any message or other electronic record other than those expressly authorized by the MyAccount service. Borrower acknowledges that, regardless of whether it is using a web browser with security features,
Lender is unable to ensure that data contained in any related Internet transmission between Lender and Borrower will not be intercepted by third parties. Borrower agrees that Lender will not be liable should any such interception occur prior to
receipt by Lender of any such data transmitted by Borrower or after transmission by Lender of any such data to Borrower. 
 5.
REPRESENTATIONS AND WARRANTIES: In consideration of Borrower’s use of and access to the MyAccount service, Borrower agrees that each transmission of electronic signatures and electronic records using its Passwords via the MyAccount site
shall be (i) deemed to be a representation and warranty by Borrower that all such electronic records are true, correct and accurate when the record is sent and that the conditions in Section 3.2 of the Loan Agreement have been
satisfied and (ii) a restatement by Borrower and each Guarantor (if any) of each of the representations and warranties made by such Person in any Loan Document and a reaffirmation by Borrower and each Guarantor (if any) of the granting and
continuance of Lender’s Liens pursuant to the Loan Documents. 
 6. DUTY TO VERIFY TRANSMISSIONS: Borrower shall
independently verify all information and calculations computed by use of the MyAccount service and immediately inform Lender of any error. No such error shall impair the validity of the Obligations, all of which shall be payable in full accordance
with the Loan Documents and Borrower hereby agrees that any such Loans made in excess of availability within the Borrowing Base or otherwise made in error shall be immediately due and payable. 
 7. SECURITY PROCEDURES: The MyAccount service uses encryption to preserve the security and integrity of Borrower’s transmissions. The parties
agree that Borrower’s Passwords affixed to or contained in an electronic record or electronic signature, together with the encrypted transmissions employed by the MyAccount service for detecting changes or errors in electronic records and
electronic signatures, shall be sufficient security procedures to verify the origin of any such transmission or the identity or authority of the Person transmitting it. Each electronic signature and electronic record transmitted to Lender via the
MyAccount service using Borrower’s Passwords shall be the act of and attributable to Borrower. 
 8. USER CONDUCT: Borrower
agrees: (a) not to use the MyAccount service in any manner that could damage, disable, 

 
overburden or impair the MyAccount service; (b) not to share Borrower’s Passwords with any other user or provide access to the MyAccount service or
site to any other person authorized to act on Borrower’s behalf. Any employee of Borrower, or authorized third party (e.g., accounting company) who requires such access, and is approved by Borrower’s User Administrator, should apply for
their own Passwords; (c) not to upload, post, or otherwise transmit through or on the MyAccount site any viruses or other harmful, disruptive or destructive files; (d) not to knowingly post on the MyAccount service or site information
which is untrue, incomplete or inaccurate; (e) not to transmit through or on the MyAccount site “spam”, chain letters, junk mail or any other type of unsolicited mass email to people or entities who have not agreed to be part of such
mailings; (f) not to post or otherwise disseminate on or through the MyAccount site harassing, defamatory, libelous, tortious, offensive, threatening, obscene or otherwise unlawful communications or materials of any kind, or materials which
infringe or violate any third party’s copyright, trademark, trade secrets, privacy or other proprietary or property right or that could constitute a criminal offense, give rise to civil liability or otherwise violate any applicable law;
(g) not to use any robot, spider or other automatic device, or manual process to monitor, extract, collect, harvest or copy the web pages or any data or data fields contained at the MyAccount site including, but not limited to, personally
identifiable information of any other user of the MyAccount site, or the names of customers of Lender or its affiliates; (h) not to modify, assign, sublicense, sell or prepare derivative works of any materials on the MyAccount site nor to
reproduce or publicly display, perform, distribute or otherwise use such materials except as expressly allowed herein; (i) to retain, on all copies of any materials downloaded, all copyright, trademark, and other proprietary notices contained
in the materials; (j) not to interfere with the security of, or otherwise abuse, the MyAccount service, or any services, system resources, accounts, servers or networks connected to or accessible through the MyAccount site or affiliated or
linked sites; (k) not to disrupt or interfere with any other Person’s use and enjoyment of the MyAccount service or affiliated or linked sites; (l) not to use or attempt to use another’s account, service or system without
authorization from Lender to create or use a false identity on the MyAccount service; (m) not to attempt to obtain unauthorized access to the MyAccount service or portions of the MyAccount service which are restricted from general access; and
(n) to comply with all applicable laws that relate to its use or activities on the MyAccount service. 
 9. SYSTEM REQUIREMENTS:
The system requirements for use of the MyAccount service are Netscape Navigator 4.7 or higher or Internet Explorer 5.5 or higher, and Internet access which allow Borrower to send and receive secure data transmissions. Borrower acknowledges that it
has the appropriate computer equipment and Internet access to use the MyAccount service and understands that its use of the Internet may incur certain operational costs such as monthly fees for a service provider. Borrower agrees to notify Lender
prior to modifying or replacing any of its software or hardware or report format which may affect the accuracy of the data required to be submitted under this Disclosure Schedule through the continued use of the MyAccount service. Borrower agrees to
notify Lender at 1-301-961-1640 in the event that it no longer desires to use the MyAccount service offered by Lender. Borrower will allow a reasonable amount of time to make appropriate changes to ensure proper delivery to Borrower through other
means. 
 10. DISCLAIMER OF WARRANTIES: Lender shall not be responsible for the accuracy, completeness or use of any information
received by Borrower through the MyAccount service. THE MYACCOUNT SITE, INCLUDING ALL SOFTWARE, FUNCTIONS AND CONTENT, ARE PROVIDED ON AN “AS IS” OR “AS AVAILABLE” BASIS. NONE OF LENDER NOR ANY OF ITS AFFILIATES OR SUPPLIERS
MAKES ANY REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, STATUTORY OR ARISING FROM COURSE OF CONDUCT, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, TITLE OR NON-INFRINGEMENT. LENDER, ITS
AFFILIATES AND SUPPLIERS MAKE NO REPRESENTATION OR WARRANTY THAT ANY CONTENT, SOFTWARE OR FUNCTIONS ACCESSED THROUGH THE MYACCOUNT SERVICE WILL BE UNINTERRUPTED OR ERROR FREE, THAT DEFECTS WILL BE CORRECTED, OR THAT THE MYACCOUNT SERVICE OR THE
SERVER THAT MAKES IT AVAILABLE IS FREE OF VIRUSES OR OTHER HARMFUL COMPONENTS. LENDER RESERVES THE RIGHT, IN ITS SOLE DISCRETION, TO MAKE ANY CHANGES TO THE MYACCOUNT SITE, THE MATERIALS AND THE PRODUCTS, PROGRAMS, SERVICES OR PRICES (IF ANY)
DESCRIBED IN THE SITE AT ANY TIME WITHOUT NOTICE. 
 11. LIMITATION OF DAMAGES: LENDER, ITS AFFILIATES AND SUPPLIERS SHALL NOT BE
RESPONSIBLE TO 

 
BORROWER OR ANY THIRD PARTY FOR ANY TRANSMISSIONS NOT ACTUALLY RECEIVED OR FOR MALFUNCTIONS IN COMMUNICATIONS FACILITIES WHICH MAY AFFECT THE ACCURACY OR
TIMELINESS OF THE ELECTRONIC RECORDS SENT OR RECEIVED, OR FOR ANY LOSSES, ERRORS OR DELAYS ARISING OUT OF BORROWER’S USE OF ANY ACCESS SERVICE PROVIDER OR CAUSED BY ANY BROWSER SOFTWARE. IN NO EVENT SHALL LENDER OR ITS AFFILIATES OR SUPPLIERS
BE LIABLE FOR DIRECT, INDIRECT, INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES (INCLUDING BUSINESS INTERRUPTION, LOSS OF INFORMATION OR PROGRAMS OR OTHER DATA ON BORROWER’S INFORMATION HANDLING SYSTEM) (EVEN IF EXPRESSLY ADVISED OF THE
POSSIBILITY OF SUCH DAMAGES) RELATED TO BORROWER’S USE OR ACCESS TO, OR BORROWER’S INABILITY TO USE OR ACCESS, THE MYACCOUNT SITE, ITS CONTENT OR FUNCTIONS OR ANY LINKED WEBSITE. IN NO EVENT SHALL THE AGGREGATE LIABILITY OF LENDER, ITS
AFFILIATES AND SUPPLIERS ARISING FROM BORROWER’S USE OR ACCESS TO, OR BORROWER’S INABILITY TO USE OR ACCESS, THE MYACCOUNT SITE, ITS CONTENT OR FUNCTIONS EXCEED ONE HUNDRED DOLLARS ($100), REGARDLESS OF THE CAUSE OF ACTION, WHETHER IN
CONTRACT, TORT OR OTHERWISE. THE LIMITATION OF DAMAGES SET FORTH ABOVE IS A FUNDAMENTAL ELEMENT OF THE BASIS OF THE BARGAIN BETWEEN LENDER AND BORROWER. THIS SERVICE WOULD NOT BE PROVIDED WITHOUT SUCH LIMITATION. 
 The limitations of liability and disclaimers herein contained apply regardless of the form of action, whether in contract, warranty, strict liability,
negligence or other tort and shall survive the termination of Borrower’s use or access to the MyAccount service, a fundamental breach or breaches, or the failure of the essential purpose of contract or the failure of an exclusive remedy.

 12. INDEMNITY: Borrower hereby indemnifies and agrees to defend (with counsel acceptable to Lender) and hold harmless Lender, its
partners, officers, agents and employees (collectively, “Indemnitee”) from and against any liability, loss, cost, expense (including reasonable attorneys’ fees and expenses for both in-house and outside counsel), claim, damage,
suit, action or proceeding ever suffered or incurred by Lender or in which Lender may ever be or become involved (whether as a party, witness or otherwise), in accordance with Section 9.17 of the Loan Agreement, in connection with any
claim of any nature arising out of their use of the MyAccount service. Borrower also agrees to indemnify the Indemnitee from any breach of these Terms and Conditions by Borrower, including use of any MyAccount site or service (other than as
expressly authorized in these Terms and Conditions), or any allegation that information or materials that Borrower provides to Lender infringes the intellectual property, confidentiality, or other rights of any third party. Borrower agrees that the
Indemnitee will have no liability in connection with any such breach or unauthorized use, and Borrower agrees to indemnify any and all resulting loss, damages, judgments, awards, costs, expenses, and attorneys’ fees of the Indemnitee in
connection therewith. Borrower will also indemnify and hold the Indemnitee harmless from any claims brought by third parties arising out of Borrower’s use of the information accessed from the MyAccount site. 
 13. WAIVER AND RELEASE: Borrower releases, discharges and holds harmless Lender and its affiliates and their respective directors, officers,
employees and agents from any and all liability, claims or causes of action (known or unknown) arising out of its or their negligence in connection with the MyAccount service including, without limitation, liabilities arising out of information
posted on the MyAccount site or otherwise provided by Lender. Borrower acknowledges that it has carefully read this waiver and release paragraph and fully understands that it is a release of liability. Borrower is waiving any right that it may have
to bring a legal action to assert a claim against Lender or the other parties set out above for its or their negligence. 
 14. NO
CONFIDENTIAL, FIDUCIARY OR CONTRACTUALLY IMPLIED RELATIONSHIP WITH LENDER: Borrower acknowledges that by using the MyAccount service, no confidential, fiduciary, contractually implied or other relationship is created between Borrower and Lender
other than the express contractual relationship provided in these Terms and Conditions and any other written agreement between Borrower and Lender (including, without limitation, the Loan Documents). 
 15. LICENSE TO LENDER TO USE INFORMATION: Lender does not claim ownership of the materials Borrower may provide to Lender (including documents,
feedback and suggestions), or upload, input or submit to the MyAccount service. However, by uploading files, inputting information or otherwise communicating on, to or through the MyAccount service, Borrower hereby 

 
grants to Lender a perpetual, worldwide, irrevocable, non-exclusive, royalty-free, transferable (with right to grant sublicenses through multiple
sublicenses) license to use, copy, adapt, distribute, display, reproduce, transmit, modify and edit such materials, in all media now known or hereafter developed, in each case in accordance with the terms of Section 16 below and the
MyAccount Privacy Policy. 
 16. AGREEMENT TO PRIVACY POLICY: Information will be collected, processed, used, communicated, and
disclosed by Lender and its affiliates for the purposes of monitoring Borrower’s accounts and business, servicing Borrower’s account, enforcing Lender’s rights, providing and offering products and services and to facilitate
transactions Borrower enters into with Lender and its affiliates. Borrower can find further information on the collection, use, communication and disclosure of its information in the MyAccount Privacy Policy. The Privacy Policy is incorporated by
reference into these Terms and Conditions. Such information that Borrower provides via the MyAccount site, together with information regarding the manner in which Borrower uses the site, will be used, processed, communicated and disclosed as
permitted by these Terms and Conditions, the Privacy Policy reproduced on the MyAccount site, other agreements between the parties related to such information, and as otherwise required by law. In the event of any conflict between these Terms and
Conditions and the Privacy Policy or any other terms on the site, these Terms and Conditions shall control. 
 17. LINKS TO AND FROM OTHER SITES: As a convenience to Borrower, the MyAccount site may contain links to websites operated by other entities. If Borrower follows those links, Borrower will leave the MyAccount
site. If Borrower decides to visit any linked website, Borrower does so at its own risk and it is Borrower’s responsibility to take all protective measures to guard against viruses or other destructive elements. Lender makes no warranty or
representation regarding, and does not endorse, approve of, sponsor or recommend any linked websites or the information appearing thereon or any of the products or services described thereon. Links do not imply that Lender sponsors, endorses, is
affiliated or associated with, or is legally authorized to use any trademark, trade name, logo or copyrighted material displayed in or accessible through the links, or that any linked site is authorized to use any trademark, trade name, logo or
copyrighted material of General Electric Company, Lender, or any of their affiliates or subsidiaries. Any such site may contain material, data or information provided, posted or offered by third parties, including but not limited to advertisements
and postings in online community discussions. Borrower agrees that neither Lender nor its affiliates, business partners or service providers shall have any liability whatsoever to Borrower for any such third party material, data or information.

 All links to the MyAccount site must be approved in writing by Lender except that Lender consents to links in which: (i) the link is
a text-only link containing only the name “gehealthcarefinance.com” or the URL “http://www.gehealthcarefinance.com”; (ii) the link “points” only to “http://www.gehealthcarefinance.com” and not to deeper
pages; (iii) the link, when activated by a user, displays this page full-screen in a fully operable and navigable browser window and not within a “frame” on the linked website; (iv) the appearance, position, and other aspects of
the link may neither create the false appearance that an entity or its activities or products are associated with or sponsored by Lender nor be such as to damage or dilute the goodwill associated with the name and trademarks of Lender. Lender
reserves the right to revoke this consent to link at any time in its sole discretion. 
 18. TELEPHONE AND COMMUNICATION CHARGES AND
EQUIPMENT: Borrower shall be solely responsible for any and all telephone and other communications and equipment charges relating to its use of the MyAccount service. All transmissions by Borrower via the MyAccount service shall be at the sole
risk of Borrower and Lender shall not be responsible for any communications line failure, equipment or systems failure or other occurrence beyond Lender’s reasonable control. 
 19. LIMITED LICENSE: Subject to the terms and conditions set forth herein, Lender hereby grants to Borrower a non-exclusive, non-transferable,
revocable, limited right to access, use and display the MyAccount service, and the visible text, graphics and images thereon and to view and download such text, graphics and images only in connection with the uploading of data and submission of
Borrowing Base Certificates in connection with requests for Revolving Credit Loans by Borrower in the United States. Borrower may not modify, assign, sublicense, sell or prepare derivative works from such text, graphic or images or reproduce or
publicly display, perform, distribute or otherwise use them for any public or commercial use. Borrower may not print or copy the HTML or other computer programs that are viewable at the MyAccount site. Borrower shall not upload or transmit to
Lender’s computer systems any computer virus, worm, time bomb or other harmful programming routine. Except as expressly provided 

 
in these Terms and Conditions, Lender does not grant to Borrower any express or implied right or license of any intellectual property including patent,
trademark, copyright, trade secret or confidential information of Lender or any of its affiliates. 
 20. SOFTWARE: Any software as well any files, images generated by such software, code and data accompanying such software (the “Software”) used or accessible through the MyAccount service are
the copyrighted works of Lender and/or its affiliates and suppliers. Lender retains full and complete title to any and all intellectual property rights it may own or license in the Software. Lender hereby grants to Borrower a non-exclusive,
non-transferable (without the right to grant sublicenses), revocable, limited license to use the Software for the sole purposes as provided in these Terms and Conditions. Borrower may not reproduce, sell, distribute, copy, assign, sublicense,
disassemble, decompile, modify or reverse engineer any of the Software or permit any other Person to do so. 
 21. COPYRIGHT: The
MyAccount site, including without limitation its content and materials, Software, functions, organization, design compilation, magnetic translation, digital conversion, content, HTML code, graphics and other files and other matters related to this
site, as well as their overall coordination, selection and arrangement (“Materials”) are protected by United States copyright laws, international conventions and other copyright laws. All rights are reserved. All Materials contained
on the MyAccount site are protected by copyright, and are either owned, controlled or licensed by Lender. Borrower agrees to comply with all applicable copyright laws in its use of the MyAccount site and to prevent any unauthorized copying of the
Materials. Borrower shall abide by this and any and all additional copyright notices, information or restrictions contained in any of these Materials. Borrower may print the materials without the express written consent of Lender; provided,
that Borrower maintains all copyright and other notices contained in such materials, but Borrower may not otherwise prepare derivative works based upon such content, nor may such content be modified, copied, distributed, framed, reproduced,
republished, downloaded, displayed, posted, transmitted, or sold in any form or by any means, in whole or in part, without prior written permission of the copyright owner. No such activity may be competitive with or derogatory to Lender and no such
express or implied right is granted. Borrower shall not distribute any of the content of any of the MyAccount site to any other person unless that person accepts all obligations under these Terms and Conditions. Any copyright owner consent may be
revoked at any time, and such consent does not include consent to republish MyAccount site information on any other Internet, Intranet or Extranet site or to incorporate the information in any other database or compilation, unless expressly given in
writing. Any other use of the content of the MyAccount site is strictly prohibited. 
 22. TRADEMARKS: MyAccount, MyAccount and other
MyAccount graphics, logos and service marks are trademarks of the General Electric Company. Such may not be copied, imitated or used, in whole or part, without the prior written consent of the General Electric Company. All other trademarks, service
marks, logos, certification marks, collective marks or trade dress, including MyAccount (collectively “Trademarks”) appearing in the MyAccount site are the property of Lender or its affiliates, business providers or service
providers. No such Trademarks may be copied, imitated, or used, in whole or in part, without prior written permission of the owner of the relevant Trademark. All page headers, custom graphics, button icons, and scripts are Trademarks owned by Lender
or its affiliates, business partners or service providers which may not be copied, imitated, or used, in whole or in part, without the relevant owner’s prior written permission. No rights to use any Trademarks are granted under these Terms and
Conditions. Certain company names and products mentioned on the MyAccount site may be claimed as Trademarks by their respective owners, who may not be affiliated with Lender its affiliates, business partners or service providers. 
 23. RESERVATION OF RIGHTS: Lender and its affiliates’ products, services, methods and processes may be covered by one or more patents or
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 EXHIBIT G-1 
 Payment Schedule for Initial Term A Loan 
  

																					
	 Date
	  	 Starting
 Balance
	  	Takedowns	  	Payment	  	Interest	  	Principal	 	 	Remaining
Balance	 
	 06/30/06
	  	$	—  	  	$	5,000,000.00	  	$	—  	  	$	—  	  	$	—  	 	 	$	5,000,000.00	 
	 07/01/06
	  	$	5,000,000.00	  	$	—  	  	$	1,661.11	  	$	1,661.11	  	$	—  	 	 	$	5,000,000.00	 
	 08/01/06
	  	$	5,000,000.00	  	$	—  	  	$	49,833.33	  	$	49,833.33	  	$	—  	 	 	$	5,000,000.00	 
	 09/01/06
	  	$	5,000,000.00	  	$	—  	  	$	49,833.33	  	$	49,833.34	  	$	—  	 	 	$	5,000,000.01	 
	 10/01/06
	  	$	5,000,000.01	  	$	—  	  	$	49,833.33	  	$	49,833.33	  	$	—  	 	 	$	5,000,000.01	 
	 11/01/06
	  	$	5,000,000.01	  	$	—  	  	$	49,833.33	  	$	49,833.33	  	$	—  	 	 	$	5,000,000.01	 
	 12/01/06
	  	$	5,000,000.01	  	$	—  	  	$	49,833.33	  	$	49,833.34	  	$	—  	 	 	$	5,000,000.02	 
	 01/01/07
	  	$	5,000,000.02	  	$	—  	  	$	49,833.33	  	$	49,833.33	  	$	—  	 	 	$	5,000,000.02	 
	 02/01/07
	  	$	5,000,000.02	  	$	—  	  	$	193,646.23	  	$	49,833.33	  	$	143,812.90	*	 	$	4,856,187.12	 
	 03/01/07
	  	$	4,856,187.12	  	$	—  	  	$	193,646.23	  	$	48,400.00	  	$	145,246.23	 	 	$	4,710,940.89	 
	 04/01/07
	  	$	4,710,940.89	  	$	—  	  	$	193,646.23	  	$	46,952.38	  	$	146,693.85	 	 	$	4,564,247.04	 
	 05/01/07
	  	$	4,564,247.04	  	$	—  	  	$	193,646.23	  	$	45,490.33	  	$	148,155.90	 	 	$	4,416,091.14	 
	 06/01/07
	  	$	4,416,091.14	  	$	—  	  	$	193,646.23	  	$	44,013.71	  	$	149,632.52	 	 	$	4,266,458.62	 
	 07/01/07
	  	$	4,266,458.62	  	$	—  	  	$	193,646.23	  	$	42,522.37	  	$	151,123.86	 	 	$	4,115,334.76	 
	 08/01/07
	  	$	4,115,334.76	  	$	—  	  	$	193,646.23	  	$	41,016.17	  	$	152,630.06	 	 	$	3,962,704.70	 
	 09/01/07
	  	$	3,962,704.70	  	$	—  	  	$	193,646.23	  	$	39,494.95	  	$	154,151.28	 	 	$	3,808,553.42	 
	 10/01/07
	  	$	3,808,553.42	  	$	—  	  	$	193,646.23	  	$	37,958.59	  	$	155,687.64	 	 	$	3,652,865.78	 
	 11/01/07
	  	$	3,652,865.78	  	$	—  	  	$	193,646.23	  	$	36,406.89	  	$	157,239.34	 	 	$	3,495,626.44	 
	 12/01/07
	  	$	3,495,626.44	  	$	—  	  	$	193,646.23	  	$	34,839.74	  	$	158,806.49	 	 	$	3,336,819.95	 
	 01/01/08
	  	$	3,336,819.95	  	$	—  	  	$	193,646.23	  	$	33,256.98	  	$	160,389.25	 	 	$	3,176,430.70	 
	 02/01/08
	  	$	3,176,430.70	  	$	—  	  	$	193,646.23	  	$	31,658.42	  	$	161,987.81	 	 	$	3,014,442.89	 
	 03/01/08
	  	$	3,014,442.89	  	$	—  	  	$	193,646.23	  	$	30,043.95	  	$	163,602.28	 	 	$	2,850,840.61	 
	 04/01/08
	  	$	2,850,840.61	  	$	—  	  	$	193,646.23	  	$	28,413.38	  	$	165,232.85	 	 	$	2,685,607.76	 
	 05/01/08
	  	$	2,685,607.76	  	$	—  	  	$	193,646.23	  	$	26,766.55	  	$	166,879.68	 	 	$	2,518,728.08	 
	 06/01/08
	  	$	2,518,728.08	  	$	—  	  	$	193,646.23	  	$	25,103.33	  	$	168,542.90	 	 	$	2,350,185.18	 
	 07/01/08
	  	$	2,350,185.18	  	$	—  	  	$	193,646.23	  	$	23,423.51	  	$	170,222.72	 	 	$	2,179,962.46	 
	 08/01/08
	  	$	2,179,962.46	  	$	—  	  	$	193,646.23	  	$	21,726.96	  	$	171,919.27	 	 	$	2,008,043.19	 
	 09/01/08
	  	$	2,008,043.19	  	$	—  	  	$	193,646.23	  	$	20,013.49	  	$	173,632.74	 	 	$	1,834,410.45	 
	 10/01/08
	  	$	1,834,410.45	  	$	—  	  	$	193,646.23	  	$	18,282.96	  	$	175,363.27	 	 	$	1,659,047.18	 
	 11/01/08
	  	$	1,659,047.18	  	$	—  	  	$	193,646.23	  	$	16,535.17	  	$	177,111.06	 	 	$	1,481,936.12	 
	 12/01/08
	  	$	1,481,936.12	  	$	—  	  	$	193,646.23	  	$	14,769.96	  	$	178,876.27	 	 	$	1,303,059.85	 
	 01/01/09
	  	$	1,303,059.85	  	$	—  	  	$	193,646.23	  	$	12,987.17	  	$	180,659.06	 	 	$	1,122,400.79	 
	 02/01/09
	  	$	1,122,400.79	  	$	—  	  	$	193,646.23	  	$	11,186.59	  	$	182,459.64	 	 	$	939,941.15	 
	 03/01/09
	  	$	939,941.15	  	$	—  	  	$	193,646.23	  	$	9,368.08	  	$	184,278.15	 	 	$	755,663.00	 
	 04/01/09
	  	$	755,663.00	  	$	—  	  	$	193,646.23	  	$	7,531.44	  	$	186,114.79	 	 	$	569,548.21	 
	 05/01/09
	  	$	569,548.21	  	$	—  	  	$	193,646.23	  	$	5,676.50	  	$	187,969.73	 	 	$	381,578.48	 
	 06/01/09
	  	$	381,578.48	  	$	—  	  	$	193,646.23	  	$	3,803.06	  	$	189,843.17	 	 	$	191,735.31	 
	 07/01/09
	  	$	191,735.31	  	$	—  	  	$	193,646.27	  	$	1,910.96	  	$	191,735.31	 	 	$	(0.00	)

	*	A portion of the Term A Facility Commitment Fee in an amount equal to $25,000 was applied in accordance with Section 2.3(f) of the Loan Agreement. 

  

 G-1 

 EXHIBIT G-2 
 Payment Schedule for Additional Term A Loan 
  

																			
	 Date
	  	 Starting
 Balance
	  	Takedowns	  	 Debt
 Service
	  	Interest	  	Principal	  	Remaining
Balance
	 9/29/2006
	  	$	—  	  	$	1,000,000.00	  	$	—  	  	$	—  	  	$	—  	  	$	1,000,000.00
	 10/1/2006
	  	$	1,000,000.00	  	$	—  	  	$	664.44	  	$	664.44	  	$	—  	  	$	1,000,000.00
	 11/1/2006
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 12/1/2006
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 1/1/2007
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 2/1/2007
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 3/1/2007
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 4/1/2007
	  	$	1,000,000.00	  	$	—  	  	$	9,966.67	  	$	9,966.67	  	$	—  	  	$	1,000,000.00
	 5/1/2007
	  	$	1,000,000.00	  	$	—  	  	$	38,729.25	  	$	9,966.67	  	$	28,762.58	  	$	971,237.40
	 6/1/2007
	  	$	971,237.40	  	$	—  	  	$	38,729.25	  	$	9,680.00	  	$	29,049.25	  	$	942,188.15
	 7/1/2007
	  	$	942,188.15	  	$	—  	  	$	38,729.25	  	$	9,390.48	  	$	29,338.77	  	$	912,849.38
	 8/1/2007
	  	$	912,849.38	  	$	—  	  	$	38,729.25	  	$	9,098.06	  	$	29,631.19	  	$	883,218.19
	 9/1/2007
	  	$	883,218.19	  	$	—  	  	$	38,729.25	  	$	8,802.74	  	$	29,926.51	  	$	853,291.68
	 10/1/2007
	  	$	853,291.68	  	$	—  	  	$	38,729.25	  	$	8,504.48	  	$	30,224.77	  	$	823,066.91
	 11/1/2007
	  	$	823,066.91	  	$	—  	  	$	38,729.25	  	$	8,203.23	  	$	30,526.02	  	$	792,540.89
	 12/1/2007
	  	$	792,540.89	  	$	—  	  	$	38,729.25	  	$	7,898.99	  	$	30,830.26	  	$	761,710.63
	 1/1/2008
	  	$	761,710.63	  	$	—  	  	$	38,729.25	  	$	7,591.72	  	$	31,137.53	  	$	730,573.10
	 2/1/2008
	  	$	730,573.10	  	$	—  	  	$	38,729.25	  	$	7,281.38	  	$	31,447.87	  	$	699,125.23
	 3/1/2008
	  	$	699,125.23	  	$	—  	  	$	38,729.25	  	$	6,967.95	  	$	31,761.30	  	$	667,363.93
	 4/1/2008
	  	$	667,363.93	  	$	—  	  	$	38,729.25	  	$	6,651.39	  	$	32,077.86	  	$	635,286.07
	 5/1/2008
	  	$	635,286.07	  	$	—  	  	$	38,729.25	  	$	6,331.69	  	$	32,397.56	  	$	602,888.51
	 6/1/2008
	  	$	602,888.51	  	$	—  	  	$	38,729.25	  	$	6,008.79	  	$	32,720.46	  	$	570,168.05
	 7/1/2008
	  	$	570,168.05	  	$	—  	  	$	38,729.25	  	$	5,682.67	  	$	33,046.58	  	$	537,121.47
	 8/1/2008
	  	$	537,121.47	  	$	—  	  	$	38,729.25	  	$	5,353.31	  	$	33,375.94	  	$	503,745.53
	 9/1/2008
	  	$	503,745.53	  	$	—  	  	$	38,729.25	  	$	5,020.67	  	$	33,708.58	  	$	470,036.95
	 10/1/2008
	  	$	470,036.95	  	$	—  	  	$	38,729.25	  	$	4,684.70	  	$	34,044.55	  	$	435,992.40
	 11/1/2008
	  	$	435,992.40	  	$	—  	  	$	38,729.25	  	$	4,345.39	  	$	34,383.86	  	$	401,608.54
	 12/1/2008
	  	$	401,608.54	  	$	—  	  	$	38,729.25	  	$	4,002.70	  	$	34,726.55	  	$	366,881.99
	 1/1/2009
	  	$	366,881.99	  	$	—  	  	$	38,729.25	  	$	3,656.59	  	$	35,072.66	  	$	331,809.33
	 2/1/2009
	  	$	331,809.33	  	$	—  	  	$	38,729.25	  	$	3,307.04	  	$	35,422.21	  	$	296,387.12
	 3/1/2009
	  	$	296,387.12	  	$	—  	  	$	38,729.25	  	$	2,953.99	  	$	35,775.26	  	$	260,611.86
	 4/1/2009
	  	$	260,611.86	  	$	—  	  	$	38,729.25	  	$	2,597.43	  	$	36,131.82	  	$	224,480.04
	 5/1/2009
	  	$	224,480.04	  	$	—  	  	$	38,729.25	  	$	2,237.32	  	$	36,491.93	  	$	187,988.11
	 6/1/2009
	  	$	187,988.11	  	$	—  	  	$	38,729.25	  	$	1,873.62	  	$	36,855.63	  	$	151,132.48
	 7/1/2009
	  	$	151,132.48	  	$	—  	  	$	38,729.25	  	$	1,506.28	  	$	37,222.97	  	$	113,909.51
	 8/1/2009
	  	$	113,909.51	  	$	—  	  	$	38,729.25	  	$	1,135.30	  	$	37,593.95	  	$	76,315.56
	 9/1/2009
	  	$	76,315.56	  	$	—  	  	$	38,729.25	  	$	760.62	  	$	37,968.63	  	$	38,346.93
	 9/29/2009
	  	$	38,346.93	  	$	—  	  	$	38,729.12	  	$	382.19	  	$	38,346.93	  	$	—  

	*	A portion of the Term Facility A Commitment Fee in an amount equal to $5,000 was applied to the in accordance with Section 2.3(f) of the Loan Agreement.

  

 G-2 

 EXHIBIT G-3 
 Payment Schedule for Term B Loan 
  

																			
	 Date
	  	 Starting
 Balance
	  	Takedowns	  	Payment	  	Interest	  	Principal	  	Remaining
Balance
	 12/    /06
	  	$	—  	  	$	2,500,000.00	  	$	0.00	  	$	0.00	  	$	0.00	  	$	2,500,000.00
	 01/01/07
	  	$	2,500,000.00	  	$	0.00	  	$	1,636.11	  	$	1,636.11	  	$	0.00	  	$	2,500,000.00
	 2/1/2007
	  	$	2,500,000.00	  	$	0.00	  	$	82,773.33	  	$	24,541.67	  	$	58,231.66	  	$	2,441,768.34
	 3/1/2007
	  	$	2,441,768.34	  	$	0.00	  	$	82,773.33	  	$	23,970.02	  	$	58,803.31	  	$	2,382,965.03
	 4/1/2007
	  	$	2,382,965.03	  	$	0.00	  	$	82,773.33	  	$	23,392.78	  	$	59,380.55	  	$	2,323,584.48
	 5/1/2007
	  	$	2,323,584.48	  	$	0.00	  	$	82,773.33	  	$	22,809.85	  	$	59,963.48	  	$	2,263,621.00
	 6/1/2007
	  	$	2,263,621.00	  	$	0.00	  	$	82,773.33	  	$	22,221.21	  	$	60,552.12	  	$	2,203,068.88
	 7/1/2007
	  	$	2,203,068.88	  	$	0.00	  	$	82,773.33	  	$	21,626.80	  	$	61,146.53	  	$	2,141,922.35
	 8/1/2007
	  	$	2,141,922.35	  	$	0.00	  	$	82,773.33	  	$	21,026.53	  	$	61,746.80	  	$	2,080,175.55
	 9/1/2007
	  	$	2,080,175.55	  	$	0.00	  	$	82,773.33	  	$	20,420.40	  	$	62,352.93	  	$	2,017,822.62
	 10/1/2007
	  	$	2,017,822.62	  	$	0.00	  	$	82,773.33	  	$	19,808.29	  	$	62,965.04	  	$	1,954,857.58
	 11/1/2007
	  	$	1,954,857.58	  	$	0.00	  	$	82,773.33	  	$	19,190.18	  	$	63,583.15	  	$	1,891,274.43
	 12/1/2007
	  	$	1,891,274.43	  	$	0.00	  	$	82,773.33	  	$	18,566.01	  	$	64,207.32	  	$	1,827,067.11
	 1/1/2008
	  	$	1,827,067.11	  	$	0.00	  	$	82,773.33	  	$	17,935.71	  	$	64,837.62	  	$	1,762,229.49
	 2/1/2008
	  	$	1,762,229.49	  	$	0.00	  	$	82,773.33	  	$	17,299.22	  	$	65,474.11	  	$	1,696,755.38
	 3/1/2008
	  	$	1,696,755.38	  	$	0.00	  	$	82,773.33	  	$	16,656.48	  	$	66,116.85	  	$	1,630,638.53
	 4/1/2008
	  	$	1,630,638.53	  	$	0.00	  	$	82,773.33	  	$	16,007.44	  	$	66,765.89	  	$	1,563,872.64
	 5/1/2008
	  	$	1,563,872.64	  	$	0.00	  	$	82,773.33	  	$	15,352.02	  	$	67,421.31	  	$	1,496,451.33
	 6/1/2008
	  	$	1,496,451.33	  	$	0.00	  	$	82,773.33	  	$	14,690.16	  	$	68,083.17	  	$	1,428,368.16
	 7/1/2008
	  	$	1,428,368.16	  	$	0.00	  	$	82,773.33	  	$	14,021.81	  	$	68,751.52	  	$	1,359,616.64
	 8/1/2008
	  	$	1,359,616.64	  	$	0.00	  	$	82,773.33	  	$	13,346.91	  	$	69,426.42	  	$	1,290,190.22
	 9/1/2008
	  	$	1,290,190.22	  	$	0.00	  	$	82,773.33	  	$	12,665.37	  	$	70,107.96	  	$	1,220,082.26
	 10/1/2008
	  	$	1,220,082.26	  	$	0.00	  	$	82,773.33	  	$	11,977.14	  	$	70,796.19	  	$	1,149,286.07
	 11/1/2008
	  	$	1,149,286.07	  	$	0.00	  	$	82,773.33	  	$	11,282.15	  	$	71,491.18	  	$	1,077,794.89
	 12/1/2008
	  	$	1,077,794.89	  	$	0.00	  	$	82,773.33	  	$	10,580.36	  	$	72,192.97	  	$	1,005,601.92
	 1/1/2009
	  	$	1,005,601.92	  	$	0.00	  	$	82,773.33	  	$	9,871.66	  	$	72,901.67	  	$	932,700.25
	 2/1/2009
	  	$	932,700.25	  	$	0.00	  	$	82,773.33	  	$	9,156.00	  	$	73,617.33	  	$	859,082.92
	 3/1/2009
	  	$	859,082.92	  	$	0.00	  	$	82,773.33	  	$	8,433.34	  	$	74,339.99	  	$	784,742.93
	 4/1/2009
	  	$	784,742.93	  	$	0.00	  	$	82,773.33	  	$	7,703.56	  	$	75,069.77	  	$	709,673.16
	 5/1/2009
	  	$	709,673.16	  	$	0.00	  	$	82,773.33	  	$	6,966.62	  	$	75,806.71	  	$	633,866.45
	 6/1/2009
	  	$	633,866.45	  	$	0.00	  	$	82,773.33	  	$	6,222.46	  	$	76,550.87	  	$	557,315.58
	 7/1/2009
	  	$	557,315.58	  	$	0.00	  	$	82,773.33	  	$	5,470.98	  	$	77,302.35	  	$	480,013.23
	 8/1/2009
	  	$	480,013.23	  	$	0.00	  	$	82,773.33	  	$	4,712.13	  	$	78,061.20	  	$	401,952.03
	 9/1/2009
	  	$	401,952.03	  	$	0.00	  	$	82,773.33	  	$	3,945.83	  	$	78,827.50	  	$	323,124.53
	 10/1/2009
	  	$	323,124.53	  	$	0.00	  	$	82,773.33	  	$	3,172.00	  	$	79,601.33	  	$	243,523.20
	 11/1/2009
	  	$	243,523.20	  	$	0.00	  	$	82,773.33	  	$	2,390.59	  	$	80,382.74	  	$	163,140.46
	 12/1/2009
	  	$	163,140.46	  	$	0.00	  	$	82,773.33	  	$	1,601.50	  	$	81,171.83	  	$	81,968.63
	 12/28/2009
	  	$	81,968.63	  	$	0.00	  	$	82,773.29	  	$	804.66	  	$	81,968.63	  	$	0.00

	*	A portion of the Term Facility B/C Commitment Fee in an amount equal to $12,500 shall be applied to the first scheduled payment in accordance with Section 2.3(f) of the Loan
Agreement. 

  

 G-3 

 EXHIBIT G-4 
 Payment Schedule for Term C Loan 
  

																			
	 Period
	  	 Starting
 Balance
	  	 Takedowns
	  	 Payment
	  	 Interest
	  	 Principal
	  	 Remaining
 Balance

	  	  	  	  	  	  
	 Term C
 Funding
 Date
	  	$	—  	  	$	2,500,000.00	  	$	—  	  	$	—  	  	$	—  	  	$	2,500,000.00
	 1
	  			  			  			  			  			  		
	 2
	  			  			  			  			  			  		
	 3
	  			  			  			  			  			  		
	 4
	  			  			  			  			  			  		
	 5
	  			  			  			  			  			  		
	 6
	  			  			  			  			  			  		
	 7
	  			  			  			  			  			  		
	 8
	  			  			  			  			  			  		
	 9
	  			  			  			  			  			  		
	 10
	  			  			  			  			  			  		
	 11
	  			  			  			  			  			  		
	 12
	  			  			  			  			  			  		
	 13
	  			  			  			  			  			  		
	 14
	  			  			  			  			  			  		
	 15
	  			  			  			  			  			  		
	 16
	  			  			  			  			  			  		
	 17
	  			  			  			  			  			  		
	 18
	  			  			  			  			  			  		
	 19
	  			  			  			  			  			  		
	 20
	  			  			  			  			  			  		
	 21
	  			  			  			  			  			  		
	 22
	  			  			  			  			  			  		
	 23
	  			  			  			  			  			  		
	 24
	  			  			  			  			  			  		
	 25
	  			  			  			  			  			  		
	 26
	  			  			  			  			  			  		
	 27
	  			  			  			  			  			  		
	 28
	  			  			  			  			  			  		
	 29
	  			  			  			  			  			  		
	 30
	  			  			  			  			  			  		
	 31
	  			  			  			  			  			  		
	 32
	  			  			  			  			  			  		
	 33
	  			  			  			  			  			  		
	 34
	  			  			  			  			  			  		
	 35
	  			  			  			  			  			  		
	 36
	  			  			  			  			  			  		
	 FINAL
	  			  			  			  			  			  		

	*	A portion of the Term Facility Commitment Fee in an amount equal to $12,500 shall be applied to the Period 1 payment in accordance with Section 2.3(f) of the Loan Agreement.

	**	Period 1 shall mean the first day of the calendar month immediately following the Term C Funding Date and each subsequent Period shall be the first day of each calendar month
thereafter. The Final Period shall be the last day of the calendar month of Period 36. 

  

 G-4 

 ANNEX A 
 INFORMATION CERTIFICATE 
  

 NIMBLEGEN SYSTEMS INC. 
 NIMBLEGEN SYSTEMS OF ICELAND, LLC 
 NIMBLEGEN SYSTEMS GMBH 
 INFORMATION CERTIFICATE 
 Dated:
December     , 2006 
 General Electric Capital Corporation 
 2 Bethesda Metro Center, Suite 600 
 Bethesda, Maryland 20814-5318 
 Ladies and Gentlemen: 
 Reference is hereby made to the
Amended and Restated Loan and Security Agreement, of even date herewith (as amended, modified, restated or replaced from time to time, the “Loan Agreement”; capitalized terms used in this Information Certificate and not otherwise
defined in this Information Certificate shall have the meanings assigned thereto in the Loan Agreement) by and among General Electric Capital Corporation, as Lender, and NimbleGen Systems Inc. and NimbleGen Systems of Iceland, LLC (collectively,
“Borrower”). To induce Lender to enter into the Loan Agreement and to fund the initial Loans provided for thereunder, Borrower and each of its Subsidiaries (collectively, “Credit Parties”) hereby provides you with
the following information regarding each Credit Party. Each Credit Party represents and warrants to Lender that the information provided in this Information Certificate is true, correct and complete as of the Closing Date. 
 A. IDENTIFICATION MATTERS 
  

	1.	The full, correct and current name of each Credit Party, as it appears in such entity’s organizational documents, is: 

 NIMBLEGEN SYSTEMS INC. 
 NIMBLEGEN
SYSTEMS OF ICELAND, LLC 
 NIMBLEGEN SYSTEMS GMBH 

	2.	Each Credit Party’s type of organization is: 

  

			
	 Credit Party
	  	 Type of Organization

	NIMBLEGEN SYSTEMS INC.	  	Corporation
	NIMBLEGEN SYSTEMS OF ICELAND, LLC	  	Limited liability company
	NIMBLEGEN SYSTEMS GMBH	  	German limited liability company

  

	3.	Each Credit Party’s jurisdiction of organization is: 

  

			
	 Credit Party
	  	 Jurisdiction of Organization

	NIMBLEGEN SYSTEMS INC.	  	Delaware
	NIMBLEGEN SYSTEMS OF ICELAND, LLC	  	Delaware
	NIMBLEGEN SYSTEMS GMBH	  	Germany

  

	4.	Each Credit Party’s jurisdictions of qualification are: 

  

			
	 Credit Party
	  	 Jurisdictions of Qualification

	NIMBLEGEN SYSTEMS INC.	  	Delaware, Wisconsin
	NIMBLEGEN SYSTEMS OF ICELAND, LLC	  	Delaware
	NIMBLEGEN SYSTEMS GMBH	  	Germany

  

	 5.
	 Each Credit Party’s federal tax identification number and state organizational identification number
is:1 

  

					
	 Credit Party
	  	 Federal Tax Identification
 Number
	  	 Organizational Identification
 Number

	NIMBLEGEN SYSTEMS INC.	  	39-2003768	  	3279855
	NIMBLEGEN SYSTEMS OF ICELAND, LLC	  	N/A	  	3459510
	NIMBLEGEN SYSTEMS GMBH	  	N/A	  	 N/A

	 1
	 Item 5 shall not apply to any US Credit Party organized under the laws of Alabama, Indiana,
Massachusetts, Nebraska, New Hampshire, New Mexico, New York, Oklahoma, South Carolina, Vermont or West Virginia. 

  

	6.	Any names of a Credit Party (as appearing in such Person’s organizational documents) not specified above in Item 1 that such Credit Party has had during the 5 year period
preceding the Closing Date are: 

  

			
	 Credit Party
	  	 Additional Names

	NIMBLEGEN SYSTEMS GMBH	  	f/k/a Chemogenix

  

	7.	No Credit Party is engaged in any joint venture or partnership with any other Person except as follows: 

 NONE 
 B. LEGAL MATTERS 
  

	8.	The officers of each Credit Party and their respective titles are: 

 SEE ATTACHED SCHEDULE B-8 
  

	9.	The members of the Board of Directors of each Credit Party (or, if such Credit Party is a limited partnership, the general partner or, if such Credit Party is a limited liability
company, the managers) are: 

 SEE ATTACHED SCHEDULE B-9 
  

	10.	The Affiliates of each Credit Party are as follows and, except as set forth below, no Credit Party is party to any agreements with any such Affiliate: 

 SEE ATTACHED SCHEDULE B-10 
  

	11.	A list of all of the material contracts to which any Credit Party is a party or by which such Credit Party is bound is set forth below. For purposes of this Item 11, the list
of material contracts should include any long term or significant customer agreements, long term or significant supply agreements, distribution agreements, real estate leases, agreements pursuant to which intellectual property is licensed or other
material licensing agreements, employment agreements, collective bargaining agreements, management and consulting agreements and equity holders’ agreements. 

 SEE ATTACHED SCHEDULE B-11 
  

	12.	A list of all of the Government Contracts to which any Credit Party is a party or by which such Credit Party is bound is set forth below: 

 SEE ATTACHED SCHEDULE B-12 
  

	13.	Except as set forth below, the execution and delivery of the Loan Documents and the consummation of the transactions contemplated thereby will not violate, conflict with or cause a
breach of, or result in the creation of a Lien under, any of the agreements identified in Items 11 or 12, any Credit Party’s organizational documents or applicable law:  

 NONE 

	14.	The following consents shall have been obtained on or prior to the Closing Date in connection with the execution and delivery of the Loan Documents and the consummation of the
transactions contemplated thereby: 

 Consent of more than 50% of outstanding Series F Preferred Stock of Nimblegen Systems,
Inc., under Section IVB3 (b)(1)(vii) of the Seventh Amended and Restated Certificate of Incorporation regarding consent to incurrence of indebtedness exceeding $500,000. 
  

	15.	Each Credit Party’s fiscal year ends on December 31 of each year. 

  

	16.	The authorized equity securities of each Credit Party, and the identity of the holders of issued equity securities with the percentage of their fully-diluted ownership of such
Credit Party, are as set forth on the Capitalization Schedule attached hereto. Any preemptive or other outstanding rights, warrants, options, conversion rights or similar agreements or understandings are described on the Capitalization Schedule.

 SEE ATTACHED SCHEDULE B-16 
  

	17.	A brief description of each Credit Party’s pension or retirement plans, deferred salary plans or other retirement or pension related benefit plan is: 

NimbleGen Systems Inc. 401(k) Plan  
  

	18.	During the 5-year period preceding the Closing Date no Credit Party has been party to any merger, consolidation, stock acquisition or purchase of all or a substantial portion of the
assets of any Person, except: 

 NONE 
  

 C. NATURE OF OPERATIONS AND LOCATIONS 
  

	19.	The following is a brief description of each Credit Party’s business: 

  

			
	 Credit Party
	  	 Business Description

	 NimbleGen Systems Inc.
 NimbleGen Systems of Iceland,
LLC
 NimbleGen Systems GMBH
	  	 Design, manufacture and build custom high density
 DNA
microarrays and the use of such arrays in
 production and sale of genetic data

  

	20.	Each location at which any Credit Party conducts business or maintains any books, records, inventory, equipment or other assets is set forth in the table below, including for each
such location a street address, the approximate size, an indication of whether the location is owned by the applicable Credit Party, leased by the applicable Credit Party (and, if so, the name and address of the owner of the location) or operated by
a third party, such as a warehouseman or processor (and, if so, the name and address of such third party). The chief executive office of each Credit Party is indicated in the table below with an asterisk (*).  

 SEE ATTACHED SCHEDULE C-20  
 D. FINANCING MATTERS

  

	21.	No Credit Party has any Indebtedness, except as set forth on the Indebtedness Schedule attached hereto. 

 NONE 
  

	22.	Any current creditors of any Credit Party that will be refinanced in connection with the funding of the initial Loans and any letters of credit currently outstanding on behalf of
any Credit Party (together with an indication of whether any such letters of credit will be replaced or collateralized on the Closing Date) are as follows:  

 NONE  
  

	23.	Each Credit Party’s assets are owned free and clear of any consensual Liens, except for the consensual Liens set forth on the Lien Schedule attached hereto.

 NONE 

	24.	No Credit Party has made any loans to, or otherwise made any Investments in, any other Persons, except as follows: 

 Stanley D. Rose borrowed $205,200 from the Company in connection with his exercise of an option to purchase 450,000 shares of the Series E Preferred
Stock of the Company on October 19, 2005. This indebtedness is evidenced by a Promissory Note dated October 19, 2005 (the “Rose Note”). The Rose Note provides that Mr. Rose will repay all principal and interest in one
lump-sum payment upon the earlier of October 7, 2015, a Change in Control (as defined in the Company’s option plan or Mr. Rose’s award agreement), a Qualified IPO (as defined in the Company’s option plan or
Mr. Rose’s award agreement) or 90 days after the termination of his employment with the Company. 
 In connection with the
execution of the Rose Note, Mr. Rose executed a Collateral Pledge Agreement regarding the shares issued in connection with the execution of the Rose Note under which Godfrey & Kahn, S.C. was designated as the collateral agent.

  

	25.	No Credit Party is obligated to pay any management, consulting or similar professional advisory fees, except:  

 SEE ATTACHED SCHEDULE E-25 
  

	26.	No Credit Party is obligated to pay any broker’s or similar fees in connection with the consummation of the transactions contemplated by the Loan Documents except:

 NONE 
 E. REGULATORY
MATTERS AND DISPUTES 
  

	27.	Any actions, suits, judgments or proceedings pending against, or, to Credit Party’s knowledge, threatened against or affecting, any Credit Party before any court or arbitrator
or any Governmental Authority, agency or official, are described on the Litigation Schedule attached hereto. 

 NONE

  

	28.	All of the material licenses, permits and certificates necessary to the operation of any Credit Party’s business are: 

 NONE 
  

	29.	All of the Governmental Approvals required by any Governmental Authority as of the Closing Date for the operation of the business and the commercial distribution of the products or
for the ownership or operation of any Location of Credit Party and each of its Subsidiaries are: 

 NONE 

	30.	Any exceptions to the lawful (i) use, exposure, release, generation, manufacture, storage, treatment, transportation or disposal of Hazardous Material on, off or from any
Location, (ii) all Hazardous Material used, treated, stored, transported to or from, generated, disposed of or handled at the Locations, or off the Locations by any Credit Party are listed below: 

 (i) None 
 (ii) see attached
Schedule E-30 
  

	31.	Any underground storage tanks present on or under each Location are:  

 NONE 
  

	32.	Any notices of non-compliance with Laws received by any Credit Party from any Governmental Authority during the 5 year period preceding the Closing Date with respect to any
Environmental Laws, securities laws or regulations, tax laws or regulations, health and safety laws or regulations or ERISA are as follows: 

 NONE 
 F. SPECIAL COLLATERAL 
  

	33.	All of the financial institutions at which any Credit Party maintains any deposit accounts, investment accounts, securities accounts or similar accounts, together with the account
number and a description for each such account, are: 

 SEE ATTACHED SCHEDULE F-33 
  

	34.	All of the items of intellectual property owned by or licensed to any Credit Party, together with the registration or application number for each such item of intellectual property
(if registered or if an application for registration has been submitted), are: 

 SEE ATTACHED SCHEDULE F-34 

 

	35.	No Credit Party has any chattel paper (whether tangible or electronic) or instruments as of the date hereof, except 

 NONE 

	36.	No Credit Party owns any equipment subject to a certificate of title statute (including, without limitation, any motor vehicles), except: 

 NONE 
  

	37.	No Credit Party owns any assets that are of a type in which a lien may be registered, recorded or filed under, or notice thereof given under, any federal statute or regulation,
except for the intellectual property identified in Item 34 above and except: 

 NONE 

	38.	No Credit Party has any letter of credit rights, any interests in commercial tort claims or any documents of title, except: 

 NONE  
  

 Lender shall be entitled to rely upon the foregoing in all respects and the undersigned is duly
authorized to execute and deliver this Information Certificate. 
  

			
	Very truly yours,
	
	NIMBLEGEN SYSTEMS INC.,
	 a Delaware corporation

	NIMBLEGEN SYSTEMS OF ICELAND, LLC, 
	 a Delaware limited liability company

		
	By:	 	 /s/ David S. Snyder

	Name	 	David S. Snyder
	Title:	 	Chief Financial Officer and Vice President
	
	NIMBLEGEN SYSTEMS GMBH,
	 a German limited liability company

		
	By:	 	 /s/ David S. Snyder

	Name:	 	 David S. Snyder

	Title:	 	 Vice President and Chief Financial Officer

 LIST OF SCHEDULES TO 
 INFORMATION CERTIFICATE 
  

			
	Officers	  	Schedule B-8
		
	Directors	  	Schedule B-9
		
	Affiliates	  	Schedule B-10
		
	Material Contracts	  	Schedule B-11
		
	Government Contracts	  	Schedule B-12
		
	Capitalization	  	Schedule B-16
		
	Leased Property	  	Schedule C-20
		
	Consulting Agreements	  	Schedule E-25
		
	Hazardous Materials	  	Schedule E-30
		
	Bank Account	  	Schedule F-33
		
	Intellectual Property	  	Schedule F-34

  

 SCHEDULE B-8 
 CREDIT PARTY: NimbleGen Systems Inc. 
  

			
	 Title
	  	 Name

	 Chairman of the Board
	  	Robert J. Palay
		
	 Vice Chairman of the Board
	  	Thomas Palay
		
	 President and Chief Executive Officer
	  	Stanley D. Rose
		
	 Chief Financial Office, Vice President and Assistant Secretary
	  	David S. Snyder
		
	 Vice President
	  	Roland Green
		
	 Vice President
	  	Emile Nuwaysir
		
	 Secretary
	  	Kenneth C. Hunt

 CREDIT PARTY: NimbleGen Systems of Iceland, LLC 
  

			
	 Title
	  	 Name

	 Sole Member
	  	NimbleGen Systems Inc.
		
	 CREDIT PARTY: NimbleGen Systems GMBH
	  	
		
	 Title
	  	 
	 Chief Executive Officer
	  	Stanley D. Rose
	 Chief Financial Officer
	  	David S. Synder

  

 SCHEDULE B-10 
  

					
	 Credit Party
	  	 Affiliates
	  	 Agreements with Affiliates

			
	NimbleGen Systems Inc.	  	NimbleGen Systems of Iceland, LLC	  	Member Agreement
			
		  	NimbleGen Systems, GMBH	  	
			
		  	Stanley Rose (Principal)	  	 Employment Agreement
 Award (Stock Option)
Agreement
 Stockholders Agreements (2)
 Collateral Pledge
Agreement
 securing the Rose Note
 Registration Rights
Agreement
 Subordinated Convertible Note and Warrant Purchase Agreement

			
		  	Roland Green (Principal)	  	 Employment Agreement
 Award (Stock Option)
Agreement
 Stockholders Agreement (2)
 Registration Rights
Agreement
 Subordinated Convertible Note and Warrant Purchase Agreement

			
		  	David S. Snyder (Principal)	  	 Employment Agreement
 Award (Stock Option)
Agreement

			
	NimbleGen Systems of Iceland, LLC	  	NimbleGen Systems Inc.	  	Member Agreement

 SCHEDULE B-11 
 Material Contracts 
  

			
	25.	  	License Agreement, Sigma Aldrich Co.
		
	26.	  	License Agreement, Oxford Gene Technology IP Limited
		
	27.	  	License Agreement, WARF
		
	28.	  	Lease Agreement, Madison
		
	29.	  	Lease Agreement, Iceland
		
	30.	  	Supply Agreement, Affymetrix
		
	31.	  	Distributor Agreement, Bucher Biotech AG
		
	32.	  	Distributor Agreement, RZPD
		
	33.	  	Distributor Agreement, Central European Biosystems
		
	34.	  	Distributor Agreement, IFOM-IEO Campus for Oncogenomics
		
	35.	  	Distributor Agreement, Genetic Research Instrumentation
		
	36.	  	Distributor Agreement, Ecogen S.A.
		
	37.	  	Distributor Agreement, Westburg
		
	38.	  	Distributor Agreement, GeneChannel Biotech
		
	39.	  	Distributor Agreement, GeneFrontier
		
	40.	  	Distributor Agreement, Research Biolabs PTE LTD
		
	41.	  	Distributor Agreement, Macrogen
		
	42.	  	Distributor Agreement, PCL Lab
		
	43.	  	Distributor Agreement, Cold Spring Biotech Corp.
		
	44.	  	Distributor Agreement, Fen Jih Biomedical & Instrument Co., Ltd.
		
	45.	  	Government Grant, R21 CA116365-01
		
	46.	  	Government Grant, 5 R01 HG003129-03
		
	47.	  	Government Grant, 5 R01 HG003107-03

  

			
	48.	  	Consulting Agreement, Dirk van den Broek
		
	49.	  	Consulting Agreement, Christian C. Oste
		
	50.	  	Consulting Agreement, David C. Sneider
		
	51.	  	Amended and Restated Supply Agreement, LindGen EHF
		
	52.	  	Supply Agreement, Proligo Products LLC
		
	53.	  	Exclusive Technology License Agreement, University of Texas System
		
	54.	  	Agreement (granting a license to), Texas Instruments Incorporated
		
	55.	  	Commercial Use License Agreement, Affymetrix, Inc.
		
	56.	  	Supply and Licence Agreement, Oxford Gene Technology (Operations) Limited
		
	57.	  	Licence Agreement, Oxford Gene Technology IP Limited
		
	58.	  	Agreement (relating to license), Wolfgang Pfleidlerer
		
	59.	  	Employment Agreements (various forms), all employees
		
	60.	  	Agreement, Robert Palay and Thomas Palay
		
	61.	  	Transaction Bonus Agreements, various employees
		
	62.	  	Award (stock option) Agreements, various employees and consultants
		
	63.	  	Letter Agreement (relating to stock option), Gregory P. McGuiness

  

 SCHEDULE B-12 
  

			
	1.	  	Government Grant, R21 CA116365-01
	2.	  	Government Grant, 5 R01 HG003129-03
	3.	  	Government Grant, 5 R01 HG003107-03

  

 Schedule B-16 
 NimbleGen Systems, Inc. Capitalization Table 
  

																																										
	 Name of Shareholder
	 	Common	 	Bridge Warrants	 	Total Common	 	Series E	 	 Series F
	 	Total	 	%
Ownership	 
	 Price Per Share
	 		 	$	0.01	 		 	$	4.20	 	$	4.20	 	$	4.20	 	$	5.00	 	$	4.50	 	$	4.50	 	$	4.50	 	$	4.50	 	$	5.00	 		 		 		
	 Date
	 		 	 	May/June 2004	 		 	 	Sept. 2004	 	 	Recap	 	 	Total	 	 	Recap	 	 	Sept. 2004	 	 	27-Jun-05	 	 	Nov. 2005	 	 	Total	 	 	Dec. 2006	 	Total	 		 		
	 Dollars Raised/Aggregate Conversion Price
	 		 			 		 	$	28,414,005	 			 			 			 	$	12,786,354	 	$	304,677	 	$	8,401,158	 	$	21,492,189	 	$	12,500,000	 		 		 		
		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 780 Partners
	 	0	 	 	49,989	 	49,989	 	 	233,570	 	 	16,728	 	 	250,298	 	 	276,014	 	 	111,725	 	 	0	 	 	55,556	 	 	167,281	 	 	0	 	276,014	 	576,301	 	2.80	%
	 Adage Capital Partners, L.P.
	 	0	 	 	0	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 			 			 			 			 	 	600,000	 	600,000	 	600,000	 		
	 Baird Venture Partners I L.P.
	 	0	 	 	58,825	 	58,825	 	 	153,195	 	 	18,370	 	 	171,565	 	 	303,105	 	 	131,421	 	 	0	 	 	52,279	 	 	183,700	 	 	0	 	303,105	 	533,495	 	2.59	%
	 Blattner, Frederick
	 	0	 	 	66,681	 	66,681	 	 	105,953	 	 	6,719	 	 	112,672	 	 	110,870	 	 	51,931	 	 	819	 	 	14,444	 	 	67,194	 	 	31,000	 	141,870	 	321,223	 	1.56	%
	 Brookside Capital Partners Fund, L.P.
	 	0	 	 	0	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 			 			 			 			 	 	1,200,000	 	1,200,000	 	1,200,000	 		
	 BVP I Affiliates Fund L.P.
	 	0	 	 	41,188	 	41,188	 	 	107,281	 	 	12,864	 	 	120,145	 	 	212,258	 	 	92,031	 	 	0	 	 	36,610	 	 	128,641	 	 	0	 	212,258	 	373,591	 	1.82	%
	 Chojnacki, Thomas P.
	 	10,000	 	 	0	 	10,000	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	10,000	 	0.05	%
	 FHF Partners
	 	0	 	 	49,989	 	49,989	 	 	232,381	 	 	15,950	 	 	248,331	 	 	263,182	 	 	103,948	 	 	0	 	 	55,556	 	 	159,504	 	 	0	 	263,182	 	561,502	 	2.73	%
	 Green, Roland
	 	67,500	 	 	6,011	 	73,511	 	 	0	 	 	407	 	 	407	 	 	6,720	 	 	4,073	 	 	0	 	 	0	 	 	4,073	 	 	0	 	6,720	 	80,638	 	0.39	%
	 Ice Nine Investments, LLC
	 	0	 	 	1,483	 	1,483	 	 	11,905	 	 	638	 	 	12,543	 	 	10,529	 	 	3,907	 	 	0	 	 	2,474	 	 	6,381	 	 	0	 	10,529	 	24,555	 	0.12	%
	 ITX International Equity Corporation
	 	0	 	 	0	 	0	 	 	714,286	 	 	0	 	 	714,286	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	714,286	 	3.47	%
	 NimbleGen, Inc.
	 	427,500	 	 	0	 	427,500	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	427,500	 	2.08	%
	 Nuwasir, Emile
	 	10,000	 	 	1,483	 	11,483	 	 	3,571	 	 	102	 	 	3,673	 	 	1,680	 	 	1,018	 	 	0	 	 	0	 	 	1,018	 	 	0	 	1,680	 	16,836	 	0.08	%
	 Sica, Frank
	 	0	 	 	49,989	 	49,989	 	 	233,571	 	 	15,950	 	 	249,521	 	 	263,182	 	 	103,948	 	 	0	 	 	55,556	 	 	159,504	 	 	72,086	 	335,268	 	634,778	 	3.08	%
	 Skyline Venture Partners Qualified Purchaser Fund II, L.P.
	 	92,094	 	 	110,517	 	202,611	 	 	964,797	 	 	45,358	 	 	1,010,155	 	 	748,407	 	 	351,253	 	 	0	 	 	102,327	 	 	453,580	 	 	157,236	 	905,643	 	2,118,409	 	10.30	%
	 Skyline Venture Partners II, L.P.
	 	7,906	 	 	9,466	 	17,372	 	 	82,822	 	 	3,894	 	 	86,716	 	 	64,244	 	 	30,152	 	 	0	 	 	8,784	 	 	38,936	 	 	13,498	 	77,742	 	181,830	 	0.88	%
	 Skyline Expansion Fund, L.P.
	 	0	 	 	0	 	0	 	 	0	 	 	22,222	 	 	22,222	 	 	366,668	 	 	0	 	 	0	 	 	222,223	 	 	222,223	 	 	218,142	 	584,810	 	607,032	 	2.95	%
	 Sneider, David
	 	69,183	 	 	6,011	 	75,194	 	 	35,714	 	 	1,119	 	 	36,833	 	 	18,455	 	 	11,185	 	 	0	 	 	0	 	 	11,185	 	 	0	 	18,455	 	130,482	 	0.63	%
	 Schott AG
	 	0	 	 	0	 	0	 	 	2,690,477	 	 	0	 	 	2,690,477	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	2,690,477	 	13.08	%
	 SWIB (State of WI Investment Board)
	 	0	 	 	133,312	 	133,312	 	 	260,476	 	 	18,386	 	 	278,862	 	 	303,374	 	 	134,974	 	 	0	 	 	48,889	 	 	183,863	 	 	100,000	 	403,374	 	815,548	 	3.96	%
	 Tactics II Investments LLC
	 	405,000	 	 	0	 	405,000	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	405,000	 	1.97	%
	 Tactics II LLC
	 	0	 	 	49,989	 	49,989	 	 	233,571	 	 	16,728	 	 	250,299	 	 	276,015	 	 	111,726	 	 	0	 	 	55,556	 	 	167,282	 	 	0	 	276,015	 	576,303	 	2.80	%
	 Treble, Michael
	 	175,000	 	 	16,692	 	191,692	 	 	23,810	 	 	1,132	 	 	24,942	 	 	18,671	 	 	11,316	 	 	0	 	 	0	 	 	11,316	 	 	0	 	18,671	 	235,305	 	1.14	%
	 Venture Investors Early Stage Fund III L.P.
	 	0	 	 	166,655	 	166,655	 	 	390,953	 	 	47,983	 	 	438,936	 	 	791,720	 	 	390,941	 	 	0	 	 	88,889	 	 	479,830	 	 	0	 	791,720	 	1,397,311	 	6.79	%
	 WARF (WI Alumni)
	 	100,000	 	 	65,019	 	165,019	 	 	233,571	 	 	18,969	 	 	252,540	 	 	312,987	 	 	123,022	 	 	0	 	 	66,667	 	 	189,689	 	 	0	 	312,987	 	730,546	 	3.55	%
	 Thomas Gorski
	 	2,000	 	 	0	 	2,000	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	2,000	 	0.01	%
	 Renee Raffel
	 	300	 	 	0	 	300	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	300	 	0.00	%
	 Wei Huang
	 	375	 	 	0	 	375	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	375	 	0.00	%
	 David Cooper
	 	18,125	 	 	0	 	18,125	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	18,125	 	0.09	%
	 Texas Instruments Incorporated
	 	66,000	 	 	0	 	66,000	 	 	17,777	 	 	0	 	 	17,777	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	83,777	 	0.41	%
	 Board of Regents U of TX Systems
	 	39,667	 	 	0	 	39,667	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	39,667	 	0.19	%
	 Harold Garner
	 	39,667	 	 	0	 	39,667	 	 	0	 	 	1,000	 	 	1,000	 	 	16,500	 	 	10,000	 	 	0	 	 	0	 	 	10,000	 	 	8,038	 	24,538	 	65,205	 	0.32	%
	 J. Warren Huff
	 	15,605	 	 	0	 	15,605	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	15,605	 	0.08	%
	 David M. Schaller
	 	7,783	 	 	0	 	7,783	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	7,783	 	0.04	%
	 Frank Gerome
	 	2,999	 	 	0	 	2,999	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	2,999	 	0.01	%
	 STARTech Seed Fund II, L.P.
	 	16,221	 	 	0	 	16,221	 	 	35,556	 	 	0	 	 	35,556	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	51,777	 	0.25	%
	 STARTech Early Ventures, LLC
	 	10,058	 	 	0	 	10,058	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	10,058	 	0.05	%
	 Kelli Thole
	 	300	 	 	0	 	300	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	300	 	0.00	%
	 Stanley D. Rose
	 	0	 	 	16,678	 	16,678	 	 	450,000	 	 	12,241	 	 	462,241	 	 	201,980	 	 	11,300	 	 	0	 	 	111,112	 	 	122,412	 	 	0	 	201,980	 	680,899	 	3.31	%
	 Rodney Wallace
	 	0	 	 	6,009	 	6,009	 	 	0	 	 	407	 	 	407	 	 	6,712	 	 	4,068	 	 	0	 	 	0	 	 	4,068	 	 	0	 	6,712	 	13,128	 	0.06	%
	 Steven Smith
	 	0	 	 	2,001	 	2,001	 	 	0	 	 	136	 	 	136	 	 	2,237	 	 	1,356	 	 	0	 	 	0	 	 	1,356	 	 	0	 	2,237	 	4,374	 	0.02	%
	 Dan Clutter
	 	0	 	 	4,003	 	4,003	 	 	0	 	 	382	 	 	382	 	 	6,310	 	 	2,712	 	 	0	 	 	1,112	 	 	3,824	 	 	0	 	6,310	 	10,695	 	0.05	%
	 Cargill, Incorporated
	 	0	 	 	0	 	0	 	 	0	 	 	156,017	 	 	156,017	 	 	2,574,277	 	 	888,889	 	 	4,612	 	 	666,667	 	 	1,560,168	 	 	100,000	 	2,674,277	 	2,830,294	 	13.76	%
	 Topspin Partners, L.P.
	 	0	 	 	0	 	0	 	 	0	 	 	41,916	 	 	41,916	 	 	691,619	 	 	147,532	 	 	59,460	 	 	212,171	 	 	419,163	 	 	0	 	691,619	 	733,535	 	3.56	%
	 Topspin Associates, L.P.
	 	0	 	 	0	 	0	 	 	0	 	 	1,985	 	 	1,985	 	 	32,754	 	 	6,984	 	 	2,815	 	 	10,052	 	 	19,851	 	 	0	 	32,754	 	34,739	 	0.17	%
	 Michael Pirrung
	 	4,000	 	 	0	 	4,000	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	4,000	 	0.02	%
	 Lawrence Butcher
	 	1,500	 	 	0	 	1,500	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	1,500	 	0.01	%
	 Asha Ramakrishna
	 	1,500	 	 	0	 	1,500	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	1,500	 	0.01	%
	 Hlynur Sigurgislason
	 	750	 	 	0	 	750	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	750	 	0.00	%
		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 Total Shares
	 	1,591,033	 	 	911,990	 	2,503,023	 	 	7,215,237	 	 	477,603	 	 	7,692,840	 	 	7,880,470	 	 	2,841,412	 	 	67,706	 	 	1,866,924	 	 	4,776,042	 	 	2,500,000	 	10,380,470	 	20,576,333	 	91.25	%
		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
																
	 GATX Warrant
	 	0	 	 	0	 	0	 	 	13,095	 	 	0	 	 	13,095	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	13,095	 		
	 GE Warrant
	 	0	 	 	0	 	0	 	 	0	 	 	4,000	 	 	4,000	 	 	66,000	 	 	0	 	 	0	 	 	0	 	 	40,000	 	 	0	 	66,000	 	70,000	 		
	 ESO-Issued Not Exercised
	 	1,121,447	 	 	0	 	1,121,447	 	 	650,000	 	 	0	 	 	650,000	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	1,771,447	 		
	 ESO-Authorized Non-Issued
	 	2,069,125	 	 	0	 	2,069,125	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	 	0	 	0	 	2,069,125	 		
		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 		
		 	4,781,605	 	 	911,990	 	5,693,595	 	 	7,878,332	 	 	481,603	 	 	8,359,935	 	 	7,946,470	 	 	2,841,412	 	 	67,706	 	 	1,866,924	 	 	4,816,042	 	 	2,500,000	 	10,446,470	 	24,500,000	 		
		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 		

 SCHEDULE C-20 
  

							
	 Credit Party
 Address
	  	Size	  	 Owned/Leased/
 Operated by Third
 Party
	  	Name and Address of Owner (if
leased) or Third-Party Operator (if
operated by a third party)
				
	 NimbleGen Systems Inc.
 One Science Court
 Madison, WI 53711
	  	12,544
useable
square feet	  	Oakbrook Commercial Real
Estate, Inc.	  	Oakbrook Commercial Real Estate, Inc.
Perry Armstrong and David Walsh
2 Science Court
Madison, WI 53711
				
	 NimbleGen Systems of Iceland, LLC
 One Science Court
 Madison, WI 53711
  
 Vinlandsleid 2-4 113 Reykjavik
	  	1.176,5
square meters	  		  	Vinlandsleid
Stangarhyl 5
Reykjavik, Iceland

 SCHEDULE E-25 
  

			
	1.	  	Consulting Agreement, Dirk van den Broek
		
	2.	  	Consulting Agreement, Christian C. Oste
		
	3.	  	Consulting Agreement, David C. Sneider
		
	4.	  	Agreement, Robert Palay and Thomas Palay
		
	5.	  	Consulting Agreements with all of the members of the Company’s Scientific Advisory Board. The current members of the Company’s Scientific Advisory Board are Michael Sussman, Franco
Cerrina, Fred Blattner and Harold “Skip” Garner.

  

 SCHEDULE E-30 
 Hazardous Materials List 
 The following summary contains materials that NimbleGen Systems Inc. uses, has used or stored that may be
considered hazardous. The materials are broken out into 2 categories per location: moderate volume usage and low volume usage. 
 United States Location

 Usage levels for the following materials is at a low level (about 100 L per month total) and disposed of via Hydrite Chemical disposal services or via
appropriate (recommended) disposal processes: 
 0.25 M 5-Ethylthio-1H-tetrazole in Acetonitrile Acetonitrile 
 90 % Pyridine, 10 mM Iodine in Water 
 Acetic Acid 
 Ethylenediamine 
 Ethanol 
 Imidazole 
 Sodium Hydroxide 
 Usage levels for the following material is very low (< 4 L per year total) and disposed of via Hydrite Chemical disposal services or via appropriate (recommended)
disposal processes: 
  

			
	0.25 M Dicyanoimidazole in Acetonitrile	 	Bis (Triethoxysilyl) Ethane
	1-s-(+)-Camphorsulfonyl-oxaviridine	 	Chlorform
	1,4 Dioxane	 	Deionized Formamide
	2-Propanol	 	Dichloromethane
	2-Butanone	 	Diisopropylamine
	3-Glycidoxypropyl Trimethoxysilane	 	Dimethyl Formamide
	4-Methyl-2-Pentanone	 	Ether
	4-Dimethylaminopyridine	 	Formaldehyde
	4-4Bis(dimethylamino)benzophenone	 	Hexane
	Acetone	 	Hydrochloric Acid
	Acryloyl Chorlide	 	
	Ammonium Hydroxide	 	Phenol
	Bis (2-Hydroxyethyl)-3-Aminopropyl 	 	Piperdine
	Triethoxysilane	 	Purum

  

			
	 Pyridine
	 	 Tetrahydrofuran,Pyridine, Methylimidazole

	 Sodium Cyanoborohydride
	 	 solution

	 Sulfuric Acid
	 	 Tetramentyl Ammonium Chloride

	 Sulfuric Acid, Peroxide solution
	 	 Toluene

	 Tert-Butylhydroperoxide
	 	 Trichloroacetic acid in

	 Tetrahydrofuran
	 	 Trichloroethane

	 Tetrahydrofuran, Acetic Anhydride solution
	 	 Triehtylamine

	 Tetrahydrofuran, Iodine solution
	 	 Vertec

		 	 p-Xylene

 Iceland Location 
 Usage levels for the following materials is moderate (about 1400 L per month total) and disposed of via Efnamottakan disposal services or via appropriate (recommended) disposal processes: 
  

			
	0.25 M 5-Ethylthio-1H-tetrazole in Acetonitrile	 	Ethanol
	90 % Pyridine, 10 mM Iodine in Water	 	Ethylenediamine
	Acetonitrile	 	Imidazole

 Usage levels for the following material is very low (< 10 L per year total) and disposed of via Efnamottakan
disposal services or via appropriate (recommended) disposal processes: 
  

			
	2-Propanol, 99% (isopropanol)	 	Phenol Chloroform: IAA
	Acetone	 	Potassium sodium aluminosilicate
	Chloroform:isoamyl alcohol	 	Pyridine
	DCI Activator	 	Sodium azide
	DTT	 	3% TCA/Dichloromethane
	Ethidium Bromide	 	Tetramethyl ammonium chloride
	Formamide	 	Toluene
	2-mercaptoethanol.min	 	 BIS(2-Hydroxyethyk)-3-

	Methanol	 	Aminopropyltriethoxysilane

 German Location 
 Usage levels for the listed “pilot scale” materials are moderate (about 150 Kg/L per month total) and disposed of via Gesellschaft zur Sondermüllbeseitigung Bayern GSB disposal services or via appropriate (recommended)
disposal processes. 
  

			
	Acetic Acid, 99 %4-tert-Buthylphenol	 	Dimethylsulfoxide
		 	Ethanol
	Acetic Anhydride	 	Ether
	Acetone	 	Ethyl Acetate
	Acetonitrile	 	Ethylnitro Benzene
	Ammonia, 25 % in water	 	Hexane
	Bromine	 	Hydrobromic Acid
	Chloroacetic Acid	 	Hydrochloric Acid, 37 %
	DCI in Isopropanol	 	Hydrogen Peroxide 35 %
	Dichloroethane	 	HMDS
	Dichloromethane	 	Methanol
	Diethylbenzene	 	Methylamine, 40 %, water
	Dimethylformamide	 	Nitric Acid 98 %

  

			
	Nitrobenzene	 	Sulfuric Acid, 98 %
	Phenoxyacetic Acid	 	Tetrahydrofurane
	Phenylacetonitrile	 	Trichloromethane
	Propanol	 	Triethylamine
	Propylene Glycol	 	Toluene
	Pyridine	 	Toluene Sulfonic Acid

  

 Usage levels for the listed “R&D” materials are moderate (about 10 Kg/L per month total) and disposed of
via Gesellschaft zur Sondermüllbeseitigung Bayern GSB disposal services or via appropriate (recommended) disposal processes. Not all chemicals listed here are considered hazardous but were included as a complete listing that is disposed of via
the above mentioned service provider or procedures. 
  

			
	Acethydrazid 90%	 	9-Anthracene-methanol, 97%
	Acetaldehyd 99%	 	Anthrachinon, 97%
	Acetonitril (trocken)	 	Anthrarufin, tech 85%
	Acetovanillone, 98%	 	Adenine
	N4- Acetylcytosin 99%	 	2’d- Adenosine
	Acetylbromid	 	Adenosine
	Acetylchlorid	 	Aluminium-Nickel-Ligierung(Raney-Typ-Kat.)
	N-Acetylglycin	 	Aluminiumbromid wasserfrei
	Acrylsäurechlorid	 	Aluminiumchlorid wasserfrei
	Acridinon 99%	 	Aluminiumisopropylat
	Actigum CS 11	 	L(+)-Ascorbic acid Sodium salt
	Actigum 5 T 1	 	Azobenzol
	Activation-Reagenz, für DNA Synthese	 	Agarose
	1-Adamantanecarbonyl-chlorid	 	Azoxybenzene, 98%
	Aktiv Kohle	 	p-Azidophenylglyoxal monohydrat = APG
	Aliquat 336	 	1H-Benzotriazol, 99%
	Aluminiumoxid für die Chromatographie	 	Benzanthron techn.
	Aldrithiol-2TM 98% (S)= 2,2’-dithiodipiridina	 	Benzalaceton
	N-Allylthioharnstoff 98% = 1-Allyl-2-thiourea	 	Benzaldehyd
	Ameisensäure 98-100%	 	Benzoylchlorid
	Amidite Diluent	 	Benzoic Hydrazide = Benzhydrazid, 98%
	2-Amino-6-methyl-pyridin	 	1,4-Benzochinon
	3-Amino-1-propanol	 	Benzophenon
	1-Amino-2-propanol 95%	 	4-Benzoyl-4’-bromobiphenyl, 99%
	6-Amino-1-hexanol	 	4-Benzoylphenylboronic acid
	2-Amino-benzonitril	 	2-(2H-Benzotriazol-2-yl)6-dodecyl-4-methylphenol
	2-Amino-5-brompyridin	 	Benzimidazol
	2-Amino-1-naphthalinsulfonsäure	 	Benzylamin
	3(3-Aminopropyl)solketal	 	Benzylcyanid
	(3-Aminopropyl) triethoxysilan 99%	 	Benzyltrimethylammoniumchlorid
	(3-Aminopropyl) trimethoxysilan 97%	 	Benzyltrimethylammoniumhydroxid 35% in
	Ammoniumhydrogenphosphat	 	CH3OH
	Ammoniumhydroxid-Lsg	 	Benzylmercaptan
	Ammonia 7N Solution in MeOH	 	Bernsteinsäureanhydrid
	Ammonium-Chlorid	 	1-Butanol
	Ammoniumsulfat	 	(+)-Biotin hydrazide
	Anisol	 	Bortrifluorid-ethylether-Komplex
	Anisaldehyd	 	Boric acid

			
	Borsäuretriisopropylester, 98%	 	N,O-Bis(trimethylsilyl)acetamid
	(tert)-Butanol	 	Bis-Tris
	(tert)-Butylmercaptan	 	(tert)-Butyldimetylsilylchlorid
	(tert)-Butylhydroperoxid Lsg. Wasserfrei	 	N-Butylharnstoff
	N-tert-Butyl-a-phenylnitrone 98%	 	Calciumchlorid
	Brom	 	Calcimhydrid
	4-Bromanilin	 	Capping-Reagenz II, für DNA Synthese
	3-Bromacetophenon 99%	 	Capping-Reagenz I, für DNA Synthese
	Brombenzol	 	Caesiumcarbonat
	4-Bromo-benzonitril	 	Celite 545
	4Brombenzophenon, 98%	 	(1S)-(+)-Campher-10-Sulfonsäure*H2O
	4-Brombenzylcyanid, 98%=4-Bromphenyacetonitril	 	Chinolin(dest)
	4-Bromo-2-nitrotoluene 97%	 	Chinoxaline 99%
	2-Brombenzylcyanid = 2-Bromphenylacetonitril,	 	4-Chlor-anilin
	97%	 	Chloral Wasserfrei
	4-Brombuttersäureethylester, 95%	 	Chlorbenzol
	5’Bromo-2’-Deoxyuridine	 	2-Chlor-benzoesäure
	1-Bromo-4-ethylbenzen	 	4-Chlorphenylhydrazine HCL, 98%
	1-Brom-3-ethylbenzene, 98%	 	1-Chloro-4-propoxy-9H-thixanthen-9-one, 97%
	2 Bromo-3 nitrotoluen, 99%	 	Chlorameisensäure-allylester
	2 Brom-6-nitrotoluol, 98%	 	Chlorameisensäure-(9-fluorenylmethyl)-ester
	2 Brom-4 nitrotoluol 98%	 	Chlorameisensäure-2,2,2-Trichlorethyl-E
	2 Brom-5 nitrotoluol 98%	 	2-Chlorobenzyl cyanid, 97%
	4 Brom-3 nitrotoluol, tech. 90%	 	3-Chlorobenzyl cyanid, 99%
	1-Bromo-2,5-dimethoxybenzene, 98%	 	4-Chlorobenzyl cyanid, 97%
	2-Bromethanol	 	Chloressigsäure
	4-Brom-3-methylanisol, 98%	 	4-Chlorphenylboronicacid, 95%
	Bromhydrochinondimethylether, 98%= 1-Bromo-	 	2 Chlorothioxanthen-9-one, 98%
	2,5-dimethoxybenzen	 	Chloroform
	N-(3-Brompropyl)phthalimid 98%	 	4-Chlor-2-nitro-anilin
	N-Bromsuccinimid	 	3-Chloro-N-methylaniline, 95%
	Bromwasserstoffsäure 48%	 	3-Chloroaniline, 99%
	3-Bromotoluene	 	3-Chloro-4-methylaniline, 99%
	2-Brom-p-xylol 99%	 	Chlortrimethylsilan
	1-Brom-2-iodobenzen 99%= 2-Bromiodbenzol	 	5-Chlorsalicylsäure 98%
	1-Brom-3-iodobenzen 98%= 3-Bromiodbenzol	 	N-Chlorsuccinimid 98%
	1-Brom-4-iodobenzen 98%= 4-Bromiodbenzol	 	2,4,6 Collidin 99%
	5-Brom-2-iodotoluol, 98%	 	Cumol
	4-Bromtoluol 98%	 	Cyanurchlorid
	3-tert-Butylphenylchlorothionoformat	 	Cyanursäure
	4-tert-Buthylphenol	 	ß-Cyclodextrin
	Buthyllithium 2,5M Lsg. in Hexanfraktion	 	a-Cyclodextrin
	tert. Butylamin 98%	 	g-Cyclodextrin
	1,4-Bis(3-aminopropoxy)-butan	 	Cyclohexanone
	4,4’-Bis(Dimethylamino)-benzophenon, 98%	 	1,3,5-Cyclohaptatrien

			
	p-Cymene 99+%	 	1,3-Dimethyl-2-imidazolidinon
	Cytidine	 	N,N-Dimethylacetamid
	2’d-Cytidine	 	2,6-Di-O-methylß-cyclodextrin
	DBU	 	2,4-Dinitrotoluol, 97%
	2’-Deoxyinosine	 	1,4-Dioxan
	2’-Deoxyuridine	 	Diphenylamin
	Dextran von Leuconostoc ssp.	 	Diphenylchlorophosphat
	Diacethyl(2,3-Butadion)	 	2,6-Di-tert-butyl-4(dimethylaminomethyl)phenol,
	Diallylamin	 	98%
	2,6-Diaminoanthrachinon 97%	 	2,6-Di-tert-butyl-4 methyphenol, 99+%
	Dibenzoylperoxid wasserfrei	 	4,4’-Di-tert-butyl-2,2’-dipyridylyl, 98%
	1,3- Dibrombenzen, 97%	 	3,5-Di-tert-butyl-4-hydroxy-benzoesäure
	Diethylenglykoldimethylether = Diglyme	 	Diphenylcarbonat
	2,4-Diethyl-9H-thixanthen-9-one, 98%	 	Diphenylcarbamoylchlorid
	Dibrombenzophenon	 	Diphenylsulfoxid, 96%
	Dichlormethan reinst	 	Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide,
	Dichloressigsäure	 	97%
	2,4-Dichlor-phenylacetonitril	 	Dipropylamin
	2,6-Dichlor-phenylacetonitril	 	EDTA - Na2
	3,4-Dichlor-phenylacetonitril	 	Eisen
	1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane	 	Eisen II sulfat 7x H2O
	3,5-Dichlorsalicylsäure 97%	 	Essigsäureanhydrid
	N,N’-Dicyclohexylcarbodiimid	 	Essigsäure Konz.(Eisessig) 100%
	2’,3’-Dideoxyinosine	 	Ethanolamin
	1,4-Diethylbenzol 96%	 	3-Ethylanilin
	Diethanolamin, 99%	 	4-Ethylanilin
	N,N-Diethyltrimethylsilylamin	 	Ethyl-4-bromobutyrate, 95%
	Diglycine = Glycyl-glycine	 	Ethylboronsäure
	Di-isopropylamin	 	Ethylendiamin
	4-Dimethylamino-pyridin	 	Ethyl-4-dimethylaminobenzoate, 99+%
	N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide-	 	Ethylendiamin-tetraessigsäure
	hydrochloride	 	4,5-Ethylenedithio-1,3-dithiol-2one, 97%
	4-Dimethylaminobenzoesäureethylester 99+%	 	Ethylenglykol
	3,4-Dimethylanilin	 	Ethylene glycol n-butylether, 99,5+%
	N,N-Dimethylformamid-dimethylacetal	 	1-Ethyl-2-nitrobenzen
	N,N-Dimethylformamid	 	1-Ethyl-4-nitrobenzen, 99%
	Dimethylmalonsäure	 	N-Ethyl-diisopropylamin
	2,4-Dimethyl-1,3-pentadiene,98+%	 	N-Ethyldiisopropylamin 99,5% Biotech grade
	2,6-Dimethyl-phenol	 	solvent
	Dimethylsulfat 99+%	 	3-Ethylphenol
	1,3-Dimethyltetrahydro-2(1H)-pyrimidinon	 	N-Ethylpiperidin
	4,4-Dimethoxytriphenylmethylchlorid	 	1-Ethylpiperidin-hypophosphit 95%
	4,4’-Dimethoxybenzophenon, 97%	 	Fluorinert
	3,4-Dimethoxybenzyl cyanid, 98%	 	9-Fluorenemethanol 99%
	3,4-Dimethoxyphenyl-boronic acid	 	2-Fluorbenzylcyanid 97%

			
	 3-Fluorbenzylcyanid 99%
	 	 Kaliumhydroxid

	 4-Fluorbenzylcyanid 99%
	 	 Kaliumhydroxid Plätzchen

	 Formaldehyd-Lsg
	 	 Kaliumiodid, 99%

	 Formamid
	 	 Kaliumnitrat

	 3-Glycidoxy-propyl-trimethoxysilan 97%
	 	 Kaliumpermanganat

	 Glycyl-glycine
	 	 Kaliumperoxodisulfat

	 Glycinanhydrid
	 	 Kalium-tert-butylat

	 Guanosine
	 	 Kieselgel Typ 44 (Trocknungsmittel)

	 2’d-Guanosine
	 	 Kieselgel 60 silanisiert

	 Harnstoff
	 	 Kupfer

	 1,1,1,3,3,3-Hexamethyldisilazan
	 	 Kupfer (I) oxid rot

	 Hexaethylenglycol 97%
	 	 Kupfer (I)-cyanid

	 Hexylamin 99%
	 	 Kupfer(II)sulfat-5hydrat

	 L-Histidinmonohydrochlorid*H2O
	 	 Küvettenreinigungs-Konzentrat

	 L-Histidin
	 	 Lithium tert-butoxid

	 Hydrazin Monohydrat
	 	 Lithiumaluminiumhydrid 1,0 M in Diethylether

	 Hydroxylamin Hydrochlorid 98%
	 	
	 Hydroxylamin-Lsg. 50% in H2O
	 	 Lithiumaluminiumhydrid 0,5M Lsg. in

	 3-Hydroxypropionitril
	 	 diethylenglykol-dimethylether

	 4-Hydroxy-3-nitroso-1-naphthalinsulfonsäure
	 	 Lithium benzoat 99%

	 4-Hydroxy-3-methoxyacetophenon, 98%
	 	 Lithiumcarbonat

	 5-Hydroxy-2-nitrobenzyl alcohol, 97%
	 	 Lowilite 92

	 Ibuprofen = S-(+)-2-(4-Isobutylphenyl)propionsäure
	 	 Lowilite 77

		 	 D(-)Mannit

	 Imidazol
	 	 Magnesiumacetat Tetrahydrat

	 Imidazol ultra für mikrobiologie
	 	 Magnesium Späne

	 3-Indolylacetonitril
	 	 Magnesiumsulfat p.A

	 Iodine 99,999%
	 	 Malonsäure dimethyl-ester

	 2-Iodbenzoesäure
	 	 2-Mercaptobenzoesäure,97%

	 Ionenaustauscher Dowex
	 	 2-Mercaptoethanol, 98%

	 Iod
	 	 MES monohydrate

	 Iodomethan
	 	 N-Methylthioharnstoff 97%

	 5-Iodo-2’-Deoxyuridine
	 	 Methansulfonsäure

	 Isobuttersäurechlorid
	 	 N-Methylanilin

	 Isobuttersäure-Anhydrid
	 	 3-Methylanilin

	 Isopropyl-9H-thioxanthen 9-one
	 	 4-Methylanisole= p-Kresol-methylether

	 Kalium-dihydrogenphosphat (KH2PO4) 99%
	 	 N-Methylaminopropyltrimethoxysilane

		 	 3-Methylaminopropyltrimethoxysilane

	 Kalium-dihydrogenphosphat (KH2PO4)(p.A.)
	 	 2-(Methylamino)ethanol 98+%

		 	 9(Methylaminomethyl) anthracen 99%

	 Kaliumacetat, p.A.
	 	 Methylamin-Lösung 33% in abs. EtOH

	 Kaliumbenzoat
	 	 Methylamin-Lösung 41% in H2O

	 Kaliumbromid
	 	 3’,4’-(Methylenedioxy)acetophenone, 98%

	 Kaliumcarbonat
	 	 3,4-(Methylendioxy)-benzoesäurenitril, 97%

	 Kalium dichromat
	 	 3,4-(Methylendioxy)-benzylcyanid 99% =

			
	3,4-Methylendioxyphenylacetonitril	 	Natriumcarbonat (technisch)
	4-Methyl-3 nitrophenol	 	Natriumcarbonat wasserfrei
	1-Methylimidazol	 	Natriumchlorid
	Methyl-triphenylphosphoniumbromid 98%	 	Natriumchlorid, p.A.
	7-Methyl-1,5,7-triazobicyclo[4,4,0]dec-5ene	 	Natriumdichromat Dihydrat
	2-Methoxybenzylcyanid = (2-Methoxyphenyl)	 	Natriumhydrid
	acetonitril	 	Natriumsulfat (waaserfrei)
	4-Methoxybenzylcyanid = (4-Methoxyphenyl)	 	Natriumsulfid
	acetonitril	 	Natriumthiosulfat Pentahydrat
	(Methoxycarbonylmethylene) triphenylphosphorane	 	4-Nitrobenzaldehyd, 98%
		 	2-Nitrobenzaldehyd, 98%
	2-Methoxy-methylethylacetat	 	2-Nitrobenzylcyanid (= 2-
	6-Methoxy-1-tetralon, 99%	 	Nitrophenylacetonitril,98%)
	2-(4-Methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine 98%	 	4-Nitro-m-Kresol
	4-Methoxytriphenylchlormethane	 	4-Nitrophenylhydrazine
	4-Methylmorpholin	 	4-Nitrophenylchloroformate
	1-Methylpyrrolidin	 	2(4-Nitrophenyl) propionic säure, 95%
	4-Methylbenzoylchlorid	 	4-Nitrobenzoylchlorid
	o-Methylbenzylcyanid, 98%	 	4-Nitrobenzophenon 99%
	3-Methylbenzylcyanid, 98%	 	Nitrobenzol
	4-Methylbenzylcyanid, 98%	 	2-(o-Nitrophenyl)-ethanol (98%)
	N-Methylharnstoff	 	2-(4-Nitrophenyl)-ethanol
	N-Methylpyrrolidon	 	Nitronium tetrafluoro-borate, 95+%
	2-Methyl-6 nitroanilin 99%	 	2-Nitrotoluol
	MES	 	4-Nitroso-N,N-dimethylanilin
	MES, Hydrate, 99,5%	 	2-Nitroso-1-naphthol
	Morpholin	 	1-Nitroso-2-naphthol
	Naphtalin	 	2-Nitroso-1-naphthol-4-sulfonsäure
	1-Naphthol, 99+%	 	4 Nitrobenzylcyanid = 4 Nitrophenylacetonitril
	2-Naphthol, 99%	 	1-Octanol
	2-Naphthylamin-1-sulfonsäure	 	Orthoessigsäure-triethylester
	1-Naphthylacetonitril, 97%	 	Oxone
	2-Naphthylacetonitril, 97%	 	4-oxo-Tempo
	Natrium	 	Oxidation-Reagenz, für DNA Synthese
	Natriumborhydrid	 	Oxidizer Solution
	Natriumcyanid 97%	 	Paraformaldehyd
	Natriumdisulfit	 	Palladium II chlorid
	Natriumetylat	 	Peressigsäure-Lösung
	di-Natriumhydrogenphosphat	 	Phenylacetonitril
	di-Natriumhydrogenphosphat*2H2O p.A.	 	Phenylboronsäure
	Natriumdihydrogenphosphat, wasserfrei, p.A	 	Phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide,
	Natriumhydroxid	 	97%
	Natriumtetraborat Wasserfrei	 	Phenylmagnesiumchlorid, 2,0M Lsg. in THF
	Natriumnitrit (reinst)	 	Phenylsilane
	Natriumhydrogencarbonat reinst	 	Phenoxyacetylchlorid 98%
		 	
		 	

			
	 Phenoxyessigsäure
	 	 Schwefelsäure rauchend

	 2-Phenoxyethanol
	 	 Schwefelsäure 95-97%-ig

	 4-Phenoxyphenylboronic acid
	 	 Salpetersäure rauchend 100%

	 Phosgen-Lösung 20%
	 	 Salpetersäure 65%

	 Phosphortrichlorid
	 	 Salzsäure rauchend (37%ig)

	 Phosphorsäure (0,1M)
	 	 Salzsäure-Lsg. für HPCE

	 Phosphorsäure kristalle 98%
	 	 Seesand

	 Phosphoroxidchlorid
	 	 Silicagel Rubin Trockenbeutel

	 Phosphat-gepufferte Salzlsg.
	 	 Silbernitrat

	 2-Picolin
	 	 Silanization Solution I

	 Piperonylonitril
	 	 Sodium Benzoate

	 Polydimethylsiloxane,aminopropyl terminated
	 	 Sodium dithionite

	 Polyethylenglykol 35’000
	 	 Sodium thiosulfate Pentahydrate

	 Polyphosphorsäure
	 	 SODOSIL RM 04

	 Polyvinyl Alkohol
	 	 Streptavidin Cy3 Conjugate

	 Polyvinylpyrrolidon
	 	 Suberic Acid bis( N-Hydroxy-succinimide ester)

	 Potassium dichromat
	 	
	 1,3-Propandiol
	 	 SSC-puffer

	 1-Propanol
	 	 SSPE Buffer Concentrate

	 2-Propanol, reinst
	 	 Sulfolan

	 Propylamin
	 	 Bis-(2-hydroxyethyl)-sulfon, 60-65%= 2,2’-

	 Pivalinsäurechlorid
	 	 Sulfonyldiethanol

	 Piperidin 99%
	 	 Tetraethylenglycoldimethylether

	 Pyrazol
	 	 1,2,3,4-Tetrahydro-naphthalin

	 1-Pyrenemethylamine HCL ,95%
	 	 Tetraethylenpentamin

	 1-Pyrenemethanol 98%
	 	 Tetraethylthiuramdisulfid

	 2-Pyridylessigsäurenitril =2-Pyridylacetonitril
	 	 Tetrabutylammoniumfluorid*3H2O

		 	 Tetranatriumsalz Hydrat (EDTA-Na4)

	 Pyridin-hydrobromid
	 	 a-Tetralone, 98%

	 Pyridin Solution, Oxidation
	 	 a-Tetralon, 96% für
Synthese

	 4-Pyrrolidino-pyridin
	 	 2,2,6,6-Tetramethyl-4-piperidone, 95%

	 Polyvinylacetat
	 	 Tetramethylene sulfoxid, 96%

	 Polypyrrole, doped, 5 wt.% solution in water
	 	 1,1,3,3-Tetramethyl-2-thiourea, 98%

		 	 Tetramethylurea

	 Poly(m-xylylenediamine-alt
	 	 N,N,N’,N’-Tetramethylethylenediamin

	 epichlorohydrin),diamine terminated
	 	 Tetramethylammonium chlorid

	 Raney-Nickel-Katalysator
	 	 N,N,N’,N’-Tetraethylethylenediamin

	 Roti- Liquid Barrier Marker
	 	 1,2,3.5-Tetra-O-acetylß—D-ribofuranose

	 Rutin hydrate
	 	 Tetrakis(triphenylphosphine)palladium

	 Sarcosin
	 	 N,N,N’,N’-Tetrakis(2-hydroxypropyl)ethylendiamin, 

	 Sarcosinanhydrid
	 	 98%

	 Salicylaldoxim
	 	 Thexyldimethylchlorsilan

	 Salicylsäure
	 	 Thiazole, p.A. 98%

	 Satiagel MM40
	 	 Thiophenol

	 Schwefelsäure100%-ig
	 	 Thiophenol Natriumsalz

			
	 Thioharnstoff
	 	 Triton

	 Thiosalicylic acid, 97% = 2-Mercaptobenzoesäure
	 	 5’-Trityl-N-benzoyl-2’-deoxyadenosine

	 Thiosemicarbazid 99%
	 	 5’-Trityl-N-acetyl-2’-deoxycytidine

	 Thionylbromid
	 	 Thianthrene-1-boronic acid

	 Thioxanthon
	 	 Tween 20

	 Thymidine
	 	 (Diisopropylamino)-Trimethylsilane

	 m-Toluidin 99% = 3-Methylanilin
	 	 Unterphosphorige Säure

	 Toluol
	 	 Urea

	 Toluol-4-sulfochlorid
	 	 Uridine

	 Toluol-4-sulfonsäure Monohydrat
	 	 Uracil

	 o-Tolylacetonitril, 98%
	 	 Viscogum BCR 21

	 Trans-4-amino-cyclohexanol-hydrochlorid
	 	 Vitamin C

	 Triacetyl-ß-cyclodextrin
	 	 trans-2(4-Biphenyl)vinylboronic acid

	 1,2,4-Triazol
	 	 Violursäure

	 Tributylphosphat
	 	 Wasserstoffperoxid 30-35%

	 Tributylzinnhydrid
	 	 Wasserstoffperoxid-Harnstoffaddukt

	 Trichlormethyl-chlorformate
	 	 Xanthagum

	 Triethylamin
	 	 Xanthone

	 Triethylammonium-Acetat-Puffer
	 	 D(+)-Xylose

	 Triethylammonium-Acetat-Puffer ~1,0M in Wasser
	 	 Zinkchlorid

	 Triethylamin-tris-hydrofluorid
	 	 Zinkbromid (wasserfrei)

	 Triethylorthoformiat
	 	 Xanthogensäure Kaliumsalz

	 2-(Trifluoromethyl) thioxanthen-9-one, 97%
	 	 Ammonia 7N Solution in MeOH

	 Trifluormethan-sulfonylchlorid
	 	 Acetaldehyd 99%

	 o-(Trifluormethyl)-benzylcyanid 98% =
	 	 N4-Acetylcytosin 99%

	 2(Trifluoromethyl) phenyl acetonitril 98%
	 	 Buthyllithium 2,5M Lsg. in Hexanfraktion

	 Trimethylsilyltrifluoromethansulfonat
	 	 Kühlschrank

	 N-[3-(Trimethoxysilyl)-propyl] aniline
	 	 Aldrithiol-2TM 98% (S)= 2,2’-dithiodipiridina

	 Trifluoromethansulfonsäure-trimethylsilylester
	 	
	 Triphenylchlormethane
	 	 3(3-Aminopropyl)solketal

	 Triphenylphosphin
	 	 3-tert-Butylphenyl chlorothionoformate 93%

	 3-(Trismethoxysilyl)-propylamin
	 	
	 Tris(hydroxymethyl)-
	 	 (+)-Biotin hydrazide

	 aminomethanhydrochlorid(p.A)
	 	 (tert)-Butylhydroperoxid Lsg. Wasserfrei

	 Tris-Borat-EDTA-Pufferlsg.
	 	
	 Tris(2,3-epoxypropyl)isocyanurate
	 	 Chlorameisensäure-allylester

	 Triisopropylbenzolsulphonylchlorid
	 	 Chlorameisensäure-(9-fluorenylmethyl)-ester

	 Trifluoressigsäure
	 	
	 Trifluoressigsäureanhydrid, 99+%
	 	 Chlorameisensäure-2,2,2-trichlorethyl-E

	 Triphenylmethanol
	 	
	 Triphenylmethylamin
	 	 Chloral Wasserfrei

	 Triphenylmethanthiol
	 	 Diacethyl(2,3-Butadion)

	 D-Tryptophan
	 	 Dibenzoylperoxid wasserfrei

	 TRIZMA-Base
	 	 N-(3-Dimethylaminopropyl)-N’-

	 Trockenperlen (Kieselgel Typ 44)
	 	 ethylcarbodiimidehydrochlor.

  

	
	5’-Dimethoxytrityl-thymidine
	5’-Dimethoxytrityl-DMF-deoxyguanosine
	
	2’-Desoxyinosine
	9-(Methylaminomethyl)anthracene 99%
	
	4-Nitrophenylchloroformate
	Natriumsulfid
	2-Nitrophenylhydrazin
	Nitronium tetrafluoro-borate, 95+%
	
	Oxidizer Solution
	Oxone
	Phosgen-Lösung 20%
	Peressigsäure
	Phenoxyacetylchlorid 98%
	Raney-Nickel-Katalysator
	Streptavidin Cy3 Conjugate
	Thionylbromid
	Tetramethylurea
	Tetrakis(triphenylphosphine)palladium
	
	Triethylammonium-Acetat-Puffer
	Triethylammonium-Acetat-Puffer ~1,0M in Wasser
	
	Trichlormethyl-chloroformate
	Trifluormethan-sulfonylchlorid
	p-Azidophenylglyoxal monohydrat = APG

  

 SCHEDULE F-34 
 NIMBLEGEN SYSTEMS INC. 
 PATENT STATUS November 15, 2005 
 WARF PATENT APPLICATIONS 
  

	 	1.	Method and Apparatus for Synthesis of Arrays of DNA Probes 

 S. N. 09/253,460 2/22/99 
 Issued as U. S. Patent No. 6,375,903 April 23, 2002 
  

	 	2.	CIP of Method and Apparatus for Synthesis etc (CIP) 

 Pending/Materials to provoke Interference have been filed. 
  

	 	3.	Method and Apparatus for Synthesis of Arrays of DNA Probes (Continuation of basic case) 

 Pending. 
  

	 	4.	Flow Cell for Synthesis of Arrays of DNA Probes and the Like (Mechanics of flow cell) 

 S. N. 09/473,369 11/10/99 
 Issued as U.S. Patent No. 6,315,958. 
  

	 	5.	Flow Cell for Synthesis of Arrays of DNA probes and the Like (continuation of flow cell case) 

 S. N. 10/053,368 11/9/01 (Continuation) 
 Issues as U.S. Patent No. 6,444,175. 
 NIMBLEGEN CASES 
  

	 	1.	Q&B 90068 Gray Scale Idea 

 Pending. S. N. 10/061,577
filed Jan 31, 2002. 
 PCT US03/02526 filed Jan 28, 2003 
  

	 	2.	Q&B 90076 Pre-patterned Positive Controls Microarrays 

 Pending. S. N. 09/994,145 filed Nov. 26, 2001. 
 PCT US02/37858 filed November 11, 2002. 
  

	 	3.	Q&B 90084 Coherent Light Optical System for MAS 

 Provisional application S. N. 60/353,491 filed Jan. 31, 2002. 
 Pending as S. N. 10/277,530 filed Oct. 21, 2002. 
 PCT US03/02524 filed Jan 28, 2003 
  

 Annex A - 1 

  

	 	4.	Q&B 90106 Volatile Buffer Hybridization Wash for Array Analysis 

 Provisional application S. N. 60/353,841 filed Feb 1, 2002. 
 Pending S. N. 10/355,784 filed Jan 31, 2003

  

	 	5.	Q&B 90114 High Contrast Flow Cell 

 Pending S. N.
10/062,918 filed Feb 1, 2002. 
 PCT US03/02541 filed Jan. 28, 2003 
 Australia 2003210720 filed Jan 28, 2003 
 Canada 2474623 filed Jan 28, 2003 
 Europe 03737558 filed Jan 28, 2003 
 Iceland 7369 filed Jan 28, 2003 
 Japan
2003-565630 filed Jan 28, 2003 
  

	 	6.	Q&B 90131 Reduced Numerical Aperture Optics for MAS 

 Pending S. N. 10/062,967 filed Jan 31, 2002. 
 PCT US03/02568 filed Jan 28, 2003 
 Canada 2474488 filed Jan 28, 2003 
 Europe
03735055 filed Jan 28, 2003 
 Iceland 7368 filed Jan 28, 2003 
 Japan 2003-564288 filed Jan 28, 2003 
  

	 	9.	Q&B 90149 Direct Detection of RNA Hybridization 

 Provisional application S. N. 60/335,377 filed Nov. 2, 2001. 
 Pending S. N. 10/062,918 filed Nov. 1, 2002 
 PCT US02/35379 filed November 11, 2002. 
  

	 	10.	Q&B 90157 Prepatterned substrate 

 Provisional
application S. N. 60/353,219 filed Jan. 31, 2002. 
 Pending S. N. 10/279.200 filed October 23, 2002. 
 PCT US03/02525 filed January 28, 2003. 
 Australia 2003214924 filed Jan 28, 2003. 
 Canada 2474601 filed Jan 28, 2003. 
 Europe 03710770 filed Jan 28, 2003. 
 Iceland
7367 filed Jan 28, 2003. 
 Japan 2003-563707 filed Jan 28, 2003. 
  

	 	11.	Q&B 90165 Array of arrays 

 Provisional application S.
N. 60/383,559 filed May 24, 2002. 
 Pending S. N. 10/444,307 filed May 23, 2003. 
 PCT US03/16429 filed May 23, 2003. 
 Australia 2003124607 filed May 23, 2003. 
 Canada 2487093 filed May 23, 2003. 
 Europe              filed May 23, 2003. 
 Iceland 7611 filed May 23, 2003. 
 Japan
2004-508254 filed May 23, 2003. 
  

  

	 	12.	Q&B 90181 Array of Arrays with visible alignment marks 

 Provisional application S. N. 60/415,119 filed Sept. 30, 2002. 
 Pending S. N. 10/675,329 filed Sept. 30, 2003. 
  

	 	13.	Q&B 90190 Sandwich Hybridization Method 

 Provisional
application S. N. 60/415,118 filed Sept. 30, 2002. 
 Combined with 90238 for conventional filing. 
  

	 	14.	Q&B 90203 Maskless Microarray with Hydrophobic barriers 

 Provisional patent S. N. 60/414,777 filed Sept. 27, 2002. 
 Pending S. N. 10/673,760 filed Sept. 29, 2003. 
 PCT US03/30298 filed Sept. 29, 2003. 
  

	 	15.	Q&B 90211 Synthesis of multiple oligos per feature 

 Provisional application S. N. 60/415,046 filed Oct 1, 2002. 
 Pending S. N. 10/674,766 filed Sept. 30, 2003. 
 PCT US03/30725 filed Sept. 30, 2003. 
  

	 	16.	Q&B 90220 Hybridization Wheel 

 Provisional application
S. N. 60/500,142 abandoned 
  

	 	17.	Q&B 90238 Parallel loading of arrays 

 Provisional
application S. N. 60/415,090 filed Oct. 1, 2002. 
 Pending S. N. 10/674,768 filed Sept. 30, 2003. 
 PCT US03/30841 filed Sept. 30, 2003. 
  

	 	18.	Q&B 00010 PCR on a chip 

 Provisional application
60/535,982 filed January 12, 2004. 
 Pending S. N. 11/034,374 filed Jan 12, 2005 
 PCT US05/00935 filed Jan 12, 2005 
  

	 	19.	Q&B 00013 AI Base Calling Algorithm 

 Provisional
application 60/539,220 filed January 26, 2004. 
 Pending S. N. 11/043,294 filed Jan. 26, 2005 
 PCT US05/02429 filed Jan 26, 2005 
  

	 	20.	Q&B 00012 Comparative Genomic Resequencing 

 Provisional application S. N. 60/560,447 filed April 8, 2004 
 Pending S.N. 11/101,841 filed April 8, 2005 
  

	 	21.	Q&B 00019 Variable Probe Length Selection 

 Provisional
application 60/581,121 filed June 18, 2004 
 Pending S.N. 11/156,439 filed June 20, 2005 
 PCT US05/22153 filed June 20, 2005 
  

  

	 	22.	Q&B 00021 Probe Optimization Methods 

 Provisional
application 60/650,265 filed Feb. 4, 2005 
 Pending S.N. 11/157,629 filed June 21, 2005 
 PCT US05/21971 filed June 21, 2005 
  

	 	23.	Optimized Probe Selection Method 

 Provisional application
60/650,265 file February 4, 2005 
 Cases acquired from Light Biology: 
  

	 	24.	U. S. Patent No. 6,295,153 to Garner 

  

	 	25.	U.S. Ser. No. 09/998,341 filed Nov. 29, 2001 Digital Optical Chemistry Micromirror Imager (Garner) 

  

	 	26.	U.S. Ser. No. 09/999,239 filed Nov. 29, 2001 Digital Chemistry Micromirror Imager (Garner)

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