Document:

EX-4.1

 Exhibit 4.1 

RESTATED 
 CERTIFICATE OF
INCORPORATION 
 OF 
 HYBRIDON,
INC. 
 Hybridon, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware,
does hereby certify as follows: 
 1. The Corporation filed its original Certificate of Incorporation with the Secretary of State of Delaware
on May 25, 1989, which Certificate of Incorporation was amended by a Certificate of Amendment of Certificate of Incorporation filed on February 21, 1990, and amended and restated by a Restated Certificate of Incorporation filed on
June 5, 1990. A Restated Certificate of Incorporation was filed with the Secretary of State of the State of Delaware on November 20, 1990, which Restated Certificate of Incorporation was amended by a Certificate of Amendment of Restated
Certificate of Incorporation filed on October 16, 1991, a Certificate of Amendment of Restated Certificate of Incorporation filed on March 3, 1992, a Certificate of Amendment of Restated Certificate of Incorporation filed on March 23,
1992, a Certificate of Amendment of Restated Certificate of Incorporation filed on October 23, 1992, a Certificate of Amendment of Restated Certificate of Incorporation filed on February 12, 1993, a Certificate of Amendment of Restated
Certificate of Incorporation filed on June 17, 1993, a Certificate of Amendment of Restated Certificate of Incorporation filed on July 13, 1993, a Certificate of Amendment of Restated Certificate of Incorporation filed on September 9,
1994, a Certificate of Amendment of Restated Certificate of Incorporation filed on July 7, 1995, a Certificate of Amendment of Restated Certificate of Incorporation filed on December 19, 1995, and a Certificate of Retirement of Stock filed
on even date herewith. 
 2. At a meeting of the Board of Directors of the Corporation, a resolution was duly adopted, pursuant to Sections
141(f) and 245 of the General Corporation Law of the State of Delaware, setting forth a Restated Certificate of Incorporation of the Corporation and declaring said Restated Certificate of Incorporation advisable. The resolution setting forth the
Restated Certificate of Incorporation is as follows: 

 RESOLVED: That the Restated Certificate of Incorporation of the Corporation, as amended,
be and hereby is amended and restated in its entirety so that the same shall read as follows: 
 FIRST: The name of the Corporation is: 

Hybridon, Inc. 

SECOND: The address of its registered office in the State of Delaware is Corporation Trust Center, 1209 Orange Street, in the City of
Wilmington, County of New Castle. The name of its registered agent at such address is The Corporation Trust Company. 
 THIRD: The nature of
the business or purposes to be conducted or promoted by the Corporation is as follows: 
 To engage in any lawful act or
activity for which corporations may be organized under the General Corporation Law of Delaware. 
 FOURTH: The total number of shares of all
classes of stock which the Corporation shall have authority to issues is One Hundred Million (100,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million ($5,000,000) shares of Preferred
Stock, $.01 par value per share (“Preferred Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Articles FOURTH. 

The following is a statement of the designations and the powers, privileges and rights, and the qualifications, limitations or
restrictions thereof in respect of each class of capital stock of the Corporation. 
  

	A.	 	COMMON STOCK. 

 1. General. The voting, dividend and liquidation
rights of the holders of the Common Stock are subject to and qualified by the rights of the holders of the Preferred Stock of any series as may be designated by the Board of Directors upon any issuance of the Preferred Stock of any series. 

2. Voting. The holders of the Common Stock are entitled to one vote for each share held at all meetings of stockholders
(and written actions in lieu of meetings). There shall be no cumulative voting. 
 The number of authorized shares of Common
Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders of a majority of the stock of the Corporation entitled to vote, irrespective of the provisions of
Section 242(b)(2) of the General Corporation Law of Delaware. 
 3. Dividends. Dividends may be declared and paid
on the Common Stock from funds lawfully available therefor as and when determined by the Board of Directors and subject to any preferential dividend rights of any then outstanding Preferred Stock. 

  
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 4. Liquidation. Upon the dissolution or liquidation of the Corporation,
whether voluntary or involuntary, holders of Common Stock will be entitled to receive all assets of the Corporation available for distribution to its stockholders, subject to any preferential rights of any then outstanding Preferred Stock. 

 

	 	B.	PREFERRED STOCK. 

 Preferred Stock may be issued from time to time in one
or more series, each of such series to have such terms as stated or expressed herein and in the resolution or resolutions providing for the issue of such series adopted by the Board of Directors of the Corporation as hereinafter provided. Any shares
of Preferred Stock which may be redeemed, purchased or acquired by the Corporation may be reissued except as otherwise provided by law. Different series of Preferred Stock shall not be construed to constitute different classes of shares for the
purposes of voting by classes unless expressly provided. 
 Authority is hereby expressly granted to the Board of Directors
from time to time to issue the Preferred Stock in one or more series, and in connection with the creation of any such series, by resolution or resolutions providing for the issue of the shares thereof, to determine and fix such voting powers, full
or limited, or no voting powers, and such designations, preferences and relative participating, optional or other special rights, and qualifications, limitations or restrictions thereof, including without limitation thereof, dividend rights,
conversion rights, redemption privileges and liquidation preferences, as shall be stated and expressed in such resolutions, all to the full extent now or hereafter permitted by the General Corporation Law of Delaware. Without limiting the generality
of the foregoing, the resolutions providing for issuance of any series of Preferred Stock may provide that such series shall be superior or rank equally or be junior to the Preferred Stock of any other series to the extent permitted by law. Except
as otherwise specifically provided in this Certificate of Incorporation, no vote of the holders of the Preferred Stock or Common Stock shall be a prerequisite to the issuance of any shares of any series of the Preferred Stock authorized by and
complying with the conditions of the Certificate of Incorporation, the right to have such vote being expressly waived by all present and future holders of the capital stock of the Corporation. 

FIFTH: The name and mailing address of the sole incorporator are as follows: 

 

			
	 Name
	  	Mailing Address
	 David P. Johst
	  	60 State Street
		  	Boston, MA 02109

 SIXTH: In furtherance of and not in limitation of powers conferred by statute, it is further provided: 

1. Election of directors need not be by written ballot. 

2. The Board of Directors is expressly authorized to adopt, amend or repeal the By-Laws of the
Corporation. 

  
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 SEVENTH: Whenever a compromise or arrangement is proposed between this corporation and its
creditors or any class of them and/or between this corporation and its stockholders or any class of them, any court of equitable jurisdiction within the State of Delaware may, on the application in a summary way of this corporation or of any
creditor or stockholder thereof, or on the application of any receiver or receivers appointed for this corporation under the provisions of section 291 of Title 8 of the Delaware Code or on the application of trustees in dissolution or of any
receiver or receivers appointed for this corporation under the provisions of section 279 of Title 8 of the Delaware Code order a meeting of the creditors or class of creditors, and/or of the stockholders or class of stockholders of this corporation,
as the case may be, to be summoned in such manner as the said court directs. If a majority in number representing three-fourths in value of the creditors or class of creditors, and/or of the stockholders or class of stockholders of this corporation,
as the case may be, agree to any compromise or arrangement and to any promise or arrangement, the said compromise or arrangement and the said reorganization shall, if sanctioned by the court to which the said application has been made, be binding on
all the creditors or class of creditors, and/or on all the stockholders or class of stockholders, of this corporation, as the case may be, and also on this corporation. 

EIGHTH: Except to the extent that the General Corporation Law of the State of Delaware prohibits the elimination or limitation of liability of
directors for breaches of fiduciary duty, no director of the Corporation shall be personally liable to the Corporation or its stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law
imposing such liability. No amendment to or repeal of this provision shall apply to or have any effect on the liability or alleged liability of any director of the Corporation for or with respect to any acts or omissions of such director occurring
prior to such amendment. 
 NINTH: 1. Action, Suits And Proceedings Other than by or in the Right of the Corporation. The Corporation
shall indemnify each person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the
right of the Corporation), by reason of the fact that he is or was, or has agreed to become, a director or officer of the Corporation, or is or was serving, or has agreed to serve, at the request of the Corporation, as a director, officer or trustee
of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan) (all such persons being referred to hereafter as an “Indemnitee”), or by reason of any
action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees) judgment, fines and amounts paid in settlement actually and reasonably incurred by him or on his behalf in connection with such
action, suit or proceeding and any appeal therefrom, if he acted in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests of the Corporation, and, with respect to any criminal action or proceeding, had no
reasonable cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption
that the person did not act in good faith and in a manner which he reasonably believed to be in, or not opposed to, the best interests of the Corporation, and, with respect to any criminal action or proceeding, had reasonable cause to believe that
his conduct was unlawful. Notwithstanding anything to the contrary in this Article, except as set forth in Section 6 below, the Corporation shall not indemnify an Indemnitee seeking indemnification in connection with a proceeding (or part
thereof) initiated by the Indemnitee unless the initiation thereof was approved by the Board of Directors of the Corporation. 

  
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 2. Actions or Suits By or in the Right of the Corporation. The Corporation shall indemnify
any Indemnitee who was or is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the Corporation to procure a judgment in its favor by reason of the fact that he is or was, or has
agreed to become, a director or officer of the Corporation, or is or was serving, or has agreed to serve, at the request of the Corporation, as a director, officer or trustee of, or in a similar capacity with, another corporation, partnership, joint
venture, trust or other enterprise (including any employee benefit plan), or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees) and amounts paid in settlement
actually and reasonably incurred by him or on his behalf in connection with such action, suit or proceeding and any appeal therefrom, if he acted in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests of
the Corporation, except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the Corporation unless and only to the extent that the Court of Chancery of
Delaware or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of such liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to
indemnity for such expenses (including attorneys’ fees) which the Court of Chancery of Delaware or such other court shall deem proper. 

3. Indemnification For Expenses Of Successful Party. Notwithstanding the other provisions of this Article, to the extent that an
Indemnitee has been successful, on the merits or otherwise, in defense of any action, suit or proceeding referred to in Sections 1 and 2 of this Article, or in defense of any claim, issue or matter therein, or on appeal from any such action, suit or
proceeding, he shall be indemnified against all expenses (including attorneys’ fees) actually and reasonably incurred by him or on his behalf in connection therewith. Without limiting the foregoing, if any action, suit or proceeding is disposed
of, on the merits or otherwise (including a disposition without prejudice), without (i) the disposition being adverse to the Indemnitee, (ii) an adjudication that the Indemnitee was liable to the Corporation, (iii) a plea of guilty or
nolo contendere by the Indemnitee, (iv) an adjudication that the Indemnitee did not act in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the Corporation, and (v) with respect to
any criminal proceeding, an adjudication that the Indemnitee had reasonable cause to believe his conduct was unlawful, the Indemnitee shall be considered for the purposes hereof to have been wholly successful with respect thereto. 

4. Notification and Defense of Claim. As a condition precedent to his right to be indemnified, the Indemnitee must notify the
Corporation in writing as soon as practicable of any action, suit, proceeding or investigation involving him for which indemnity will or could be sought. With respect to any action, suit, proceeding or investigation of which the Corporation is so
notified, the Corporation will be entitled to participate therein at its own expense and/or to assume the defense thereof at its own expense, with legal counsel reasonably acceptable to the Indemnitee. After notice from the Corporation to the
Indemnitee of its election so to assume such defense, the Corporation shall not be liable to the Indemnitee for any legal or other expenses subsequently incurred by the Indemnitee in connection with such claim, other than as provided below in this
Section 4. The Indemnitee shall have the right to employ his own counsel in connection with such claim, but the fees and expenses of such counsel incurred after notice from the Corporation of its assumption of the defense thereof shall be at
the expense of the Indemnitee unless (i) the employment of counsel by the Indemnitee has been authorized by the 

  
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Corporation, (ii) counsel to the Indemnitee shall have reasonably concluded that there may be a conflict of interest or position on any significant issue between the Corporation and the
Indemnitee in the conduct of the defense of such action or (iii) the Corporation shall not in fact have employed counsel to assume the defense of such action, in each of which cases the fees and expenses of counsel for the Indemnitee shall be
at the expense of the Corporation, except as otherwise expressly provided by this Article. The Corporation shall not be entitled, without the consent of the Indemnitee, to assume the defense of any claim brought by or in the right of the Corporation
or as to which counsel for the Indemnitee shall have reasonably made the conclusion provided for in clause (ii) above. 

5. Advance of Expenses. Subject to the provisions of Section 6 below, in the event that the Corporation does not
assume the defense pursuant to Section 4 of this Article of any action, suit, proceeding or investigation of which the Corporation receives notice under this Article, any expenses (including attorneys’ fees) incurred by an Indemnitee in
defending a civil or criminal action, suit, proceeding or investigation or any appeal therefrom shall be paid by the Corporation in advance of the final disposition of such matter, provided, however, that the payment of such expense
incurred by an Indemnitee in advance of the final disposition of such matter shall be made only upon receipt of an undertaking by or on behalf of the Indemnitee to repay all amounts so advanced in the event that it shall ultimately be determined
that the Indemnitee is not entitled to be indemnified by the Corporation as authorized in this Article. Such undertaking may be accepted without reference to the financial ability of such person to make such repayment. 

6. Procedure for Indemnification. In order to obtain indemnification or advancement of expenses pursuant to
Section 1, 2, 3 or 5 of this Article, the Indemnitee shall submit to the Corporation a written request, including in such request such documentation and information as is reasonably available to the Indemnitee and is reasonably necessary to
determine whether and to what extent the Indemnitee is entitled to indemnification or advancement of expenses. Any such indemnification or advancement of expenses shall be made promptly, and in any event within 60 days after receipt by the
Corporation of the written request of the Indemnitee, unless with respect to requests under Section 1, 2 or 5 the Corporation determines, by clear and convincing evidence, within such 60-day period that
the Indemnitee did not meet the applicable standard of conduct set forth in Section 1 or 2, as the case may be. Such determination shall be made in each instance by (a) a majority vote of a quorum of the directors of the Corporation
consisting of persons who are not at that time parties to the action, suit or proceeding in question (“disinterested directors’), (b) if no such quorum is obtainable, a majority vote of a committee of two or more disinterested
directors, (c) a majority vote of a quorum of the outstanding shares of stock of all classes entitled to vote for directors, voting as a single class, which quorum shall consist of stockholders who are not at that time parties to the action,
suit or proceeding in question, (d) independent legal counsel (who may be regular legal counsel to the Corporation), or (e) a court of competent jurisdiction. 

7. Remedies. The right to indemnification or advances as granted by this Article shall be enforceable by the Indemnitee
in any court of competent jurisdiction if the Corporation denies such request, in whole or in part, or if no disposition thereof is made within the 60-day period referred to above in Section 6. Unless
otherwise provided by law, the burden of proving that the Indemnitee is not entitled to indemnification or advanced of expenses under this Article 

  
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shall be on the Corporation. Neither the failure of the Corporation to have made a determination prior to the commencement of such action that indemnification is proper in the circumstances
because the Indemnitee has met the applicable standard of conduct, nor an actual determination by the Corporation pursuant to Section 6 that the Indemnitee has not met such applicable standard of conduct, shall be a defense to the action or
create a presumption that the Indemnitee has not met the applicable standard of conduct. The Indemnitee’s expenses (including attorneys’ fees) incurred in connection with successfully establishing his right to indemnification, in whole or
in part, in any such proceeding shall also be indemnified by the Corporation. 
 8. Subsequent Amendment. No
amendment, termination or repeal of this Article or of the relevant provisions of the General Corporation Law of Delaware or any other applicable laws shall affect or diminish in any way the rights of any Indemnitee to indemnification under the
provisions hereof with respect to any action, suit, proceeding or investigation arising out of or relating to any actions, transactions or facts occurring prior to the final adoption of such amendment, termination or repeal. 

9. Other Rights. The indemnification and advancement of expenses provided by this Article shall not be deemed exclusive
of any other rights to which an Indemnitee seeking indemnification or advancement of expenses may be entitled under any law (common or statutory), agreement or vote of stockholders or disinterested directors or otherwise, both as to action in his
official capacity and as to action in any other capacity while holding office for the Corporation, and shall continue as to an Indemnitee who has ceased to be a director or officer, and shall inure to the benefit of the estate, heirs, executors and
administrators of the Indemnitee. Nothing contained in this Article shall be deemed to prohibit, and the Corporation is specifically authorized to enter into, agreements with officers and directors providing indemnification rights and procedures
different from those set forth in this Article. In addition, the Corporation may, to the extent authorized from time to time by its Board of Directors, grant indemnification rights to other employees or agents of the Corporation or other persons
serving the Corporation and such rights may be equivalent to, or greater or less than, those set forth in this Article. 

10. Partial Indemnification. If an Indemnitee is entitled under any provision of this Article to indemnification by the
Corporation for some or a portion of the expenses (including attorneys’ fees), judgments, fines or amounts paid in settlement actually and reasonably incurred by him or on his behalf in connection with any action, suit, proceeding or
investigation and any appeal, therefrom but not, however, for the total amount thereof, the Corporation shall nevertheless indemnify the Indemnitee for the portion of such expenses (including attorneys’ fees), judgments, fines or amounts paid
in settlement to which the Indemnitee is entitled. 
 11. Insurance. The Corporation may purchase and maintain
insurance, at its expense, to protect itself and any director, officer, employee or agent of the Corporation or another corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan) against any expense,
liability or loss incurred by him in any such capacity, or arising out of his status as such, whether or not the Corporation would have the power to indemnify such person against such expense, liability or loss under the General Corporation law of
Delaware. 
 12. Merger or Consolidation. If the Corporation is merged into or consolidated with another corporation
and the Corporation is not the surviving corporation, the surviving corporation shall assume the obligations of the Corporation under this Article with respect to any action, suit, proceeding or investigation arising out of or relating to any
actions, transactions or facts occurring prior to the date of such merger or consolidation. 

  
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 13. Savings Clause. If this Article or any portion hereof shall be
invalidated on any ground by any court of competent jurisdiction, then the Corporation shall nevertheless indemnify each Indemnitee as to any expenses (including attorneys’ fees) judgments, fines and amounts paid in settlement in connection
with any action, suit, proceeding or investigation, whether civil, criminal or administrative, including an action by or in the right of the Corporation, to the fullest extent permitted by any applicable portion of this Article that shall not have
been invalidated and to the fullest extent permitted by applicable law. 
 14. Definitions. Terms used herein and
defined in Section 145(h) and Section 145(i) of the General Corporation Law of Delaware shall have the respective meanings assigned to such terms in such Section 145(h) and Section 145(i). 

15. Subsequent Legislation. If the General Corporation Law of Delaware is amended after adoption of this Article to
expand further the indemnification permitted to Indemnitees, then the Corporation shall indemnify such persons to the fullest extent permitted by the General Corporation Law of Delaware, as so amended. 

TENTH: The Corporation reserves the right to amend, alter, change or repeal any provision contained in this Restated Certificate of
Incorporation, in the manner now or hereafter prescribed by statute and this Restated Certificate of Incorporation, and all rights conferred upon stockholders herein are granted subject to this reservation. 

ELEVENTH: This Article is inserted for the management of the business and for the conduct of the affairs of the Corporation and shall not
become effective until the closing of the sale of shares of Common Stock in an underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended, resulting in at least $10,000,000 of gross
proceeds to the Corporation (a “Public Offering”). 
 1. Number of Directors. The number of directors of the
Corporation shall not be less than three. The exact number of directors within the limitations specified in the preceding sentence shall be fixed from time to time by, or in the manner provided in, the Corporation’s By-Laws. 
 2. Classes of Directors. The Board of Directors shall be and is divided
into three classes: Class I, Class II and Class III. No one class shall have more than one director more than any other class. If a fraction is contained in the quotient arrived at by dividing the designated number of directors by three, then, if
such fraction is one-third, the extra director shall be a member of Class II, and if such fraction is two-thirds, one of the extra directors shall be a member of Class I
and one of the extra directors shall be a member of Class II, unless otherwise provided from time to time by resolution adopted by the Board of Directors. 

3. Election of Directors. Elections of directors need not be by written ballot except as and to the extent provided in
the By-Laws of the Corporation. 

  
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 4. Terms of Office. Each director shall serve for a term ending on the
date of the third annual meeting following the annual meeting at which such director was elected; provided, that each initial director in Class I shall serve for a term ending on the date of the annual meeting in 1996; each initial director
in Class II shall serve for a term ending on the date of the annual meeting in 1997; and each initial director in Class III shall serve for a term ending on the date of the annual meeting in 1998; and provided further, that the term of each
director shall be subject to the election and qualification of his successor and to his earlier death, resignation or removal. 

5. Allocation of Directors Among Classes in the Event of Increases or Decreases in the Number of Directors. In the event
of any increase or decrease in the authorized number of directors, (i) each director then serving as such shall nevertheless continue as a director of the class of which he is a member and (ii) the newly created or eliminated directorships
resulting from such increase or decrease shall be apportioned by the Board of Directors among the three classes of directors so as to ensure that no one class has more than one director more than any other class. To the extent possible, consistent
with the foregoing rule, any newly created directorships shall be added to those classes whose terms of office are to expire at the latest dates following such allocation, and any newly eliminated directorships shall be subtracted from those classes
whose terms of offices are to expire at the earliest dates following such allocation, unless otherwise provided from time to time by resolution adopted by the Board of Directors. 

6. Quorum; Action at Meeting. A majority of the directors at any time in office shall constitute a quorum for the
transaction of business. In the event one or more of the directors shall be disqualified to vote at any meeting, then the required quorum shall be reduced by one for each director so disqualified, provided that in no case shall less than one-third of the number of directors fixed pursuant to Section 1 above constitute a quorum. If at any meeting of the Board of Directors there shall be less than such a quorum, a majority of those present may
adjourn the meeting from time to time. Every act or decision done or made by a majority of the directors present at a meeting duly held at which a quorum is present shall be regarded as the act of the Board of Directors unless a greater number is
required by law, by the By-Laws of the Corporation or by this Restated Certificate of Incorporation. 

7. Removal. Directors of the Corporation may be removed only for cause by the affirmative vote of the holders of at
least two-thirds of the shares of the capital stock of the Corporation issued and outstanding and entitled to vote. 

8. Vacancies. Any vacancy in the Board of Directors, however occurring, including a vacancy resulting from an
enlargement of the board, shall be filled only by a vote of a majority of the directors then in office, although less than a quorum, or by a sole remaining director. A director elected to fill a vacancy shall be elected to hold office until the next
election of the class for which such director shall have been chosen, subject to the election and qualification of his successor and to his earlier death, resignation or removal. 

9. Stockholder Nominations and Introduction of Business, Etc. Advance notice of stockholder nominations for election of
directors and other business to be brought by stockholders before a meeting of stockholders shall be given in the manner provided by the By-Laws of the Corporation. 

  
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 10. Amendments to Article. Notwithstanding any other provisions of law,
this Restated Certificate of Incorporation or the By-Laws of the Corporation, and notwithstanding the fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at least
seventy-five percent (75%) of the shares of capital stock of the Corporation issued and outstanding and entitled to vote shall be required to amend or repeal, or to adopt any provision inconsistent with, this Article ELEVENTH. 

TWELFTH: Until the closing of a Public Offering, any action which is required to be taken or which may be taken at any annual or special
meeting of stockholders of the Corporation may be taken without a meeting, without prior notice and without a vote, if a consent in writing, setting forth the action so taken, is signed by the holders of outstanding stock having not less than the
minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote on such action were present and voted. Effective upon the closing of a Public Offering, stockholders of the
Corporation may not take any action by written consent in lieu of a meeting. Notwithstanding any other provisions of law, the Restated Certificate of Incorporation or the By-Laws of the Corporation, and
notwithstanding the fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at least seventy-five percent (75%) of the shares of capital stock of the Corporation issued and outstanding and entitled to vote
shall be required to amend or repeal, or to adopt any provision inconsistent with, this Article TWELFTH. 
 THIRTEENTH: Effective upon the
closing of a Public Offering, special meetings of stockholders may be called at any time by only the Chief Executive Officer (or if there is no Chief Executive Officer, the President) or the Board of Directors. Business transacted at any special
meeting of stockholders shall be limited to matters relating to the purpose or purposes stated in the notice of meeting. Notwithstanding any other provision of law, this Restated Certificate of Incorporation or the
By-Laws of the Corporation, as amended, and notwithstanding the fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at least seventy-five percent (75%) of the
shares of capital stock of the Corporation issued and outstanding and entitled to vote shall be required to amend or repeal, or to adopt any provision inconsistent with this Article THIRTEENTH. 

  
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 IN WITNESS WHEREOF, the Corporation has caused its corporate seal to be affixed hereto and this
Restated Certificate of Incorporation to be signed by its Chairman this 28th March, 1996. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ E. Andrews Grinstead, III
		 	Chairman

 [Corporate Seal] 

  
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 CERTIFICATE OF AMENDMENT 

OF RESTATED 
 CERTIFICATE OF
INCORPORATION 
 OF HYBRIDON, INC. 

Pursuant to Section 242 of the General 

Corporation Law of the State of Delaware 
  

 
 HYBRIDON, INC.
(the “Corporation”), organized and existing under and by virtue of the General Corporation Law of the State of Delaware, does hereby certify as follows: 

By written action of the Board of Directors of the Corporation, dated October 20, 1997, the Board of Directors duly adopted resolutions
pursuant to Sections 141(f) and 242 of the General Corporation Law of the State of Delaware setting forth an amendment to the Restated Certificate of Incorporation of the Corporation, as amended, and declaring said amendment to be advisable. The
stockholders of the Corporation duly approved, pursuant to said Section 242, said proposed amendment at a Special Meeting of Stockholders held on November 18, 1997. The resolution setting forth the amendment to the Restated Certificate of
Incorporation is as follows: 
  

	RESOLVED:	That, subject to stockholder approval, the following paragraph be inserted prior to the first paragraph of Article FOURTH of the Certificate of Incorporation: 

“That upon the filing date of the Certificate of Amendment of Restated Certificate of Incorporation of the Corporation
(the “Effective Date”), a one-for-five reverse split of the Corporation’s Common Stock (as defined below) shall become effective, such that each five
shares of Common Stock outstanding and held of record by each stockholder of the Corporation (including treasury shares) immediately prior to the Effective Date shall represent one share of Common Stock from and after the Effective Date.” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be executed by its Chairman of the Board of Directors,
President and Chief Executive Officer this 10th day of December, 1997. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ E. Andrews Grinstead, III
		 	E. Andrews Grinstead, III
		 	 Chairman of the Board of Directors,

President and Chief Executive Officer

 CERTIFICATE OF DESIGNATION 

for 
 SERIES A CONVERTIBLE PREFERRED
STOCK 
 of 
 HYBRIDON, INC. 

Pursuant to Section 151 of the 

General Corporation Law of the State of Delaware 

HYBRIDON INC., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby certify
that pursuant to the authority conferred on the board of directors of the Corporation (the “Board of Directors”) by the Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”) of the Corporation and
in accordance with Section 151 of the General Corporation Law of the State of Delaware, the Board of Directors adopted the following resolution establishing a series of 1,500,000 shares of preferred stock of the Corporation designated as
“Series A Convertible Preferred Stock”: 
 RESOLVED, that pursuant to the authority conferred on the Board of
Directors by the Certificate of Incorporation, a series of preferred stock, par value $.01 per share, of the Corporation is hereby established and created, and that the designation and number of shares thereof and the voting and other powers,
preferences and relative participating, optional or other special rights of, the shares of such series and the qualifications, limitations and restrictions thereof are as follows: 

Series A Convertible Preferred Stock 

1. Designation and Amount and Definitions. (a) There shall be a series of Preferred Stock designated as “Series A Convertible
Preferred Stock” and the number of shares constituting such series shall be 1,500,000. Such series is referred to herein as the “Series A Preferred Stock”. Notwithstanding any other provision in this Certificate of Designation of the
Series A Preferred Stock (the “Certificate of Designation”) to the contrary, such series shall be senior to the common stock, par value $.001 per share of the Corporation (the “Common Stock”) with respect to dividends and the
distribution of assets upon liquidation, dissolution or winding up. Such number of shares may be increased or decreased by resolution of the Board of Directors, subject to the provisions of Section 7 hereof; provided, however, that no decrease
shall reduce the number of shares of Series A Preferred Stock to fewer than the number of shares then issued and outstanding. 
 (b) As used
in this Certificate of Designation, except as otherwise provided in Subsection 4(c), the following terms shall have the following meanings: 

(i) The “Closing Bid Price” for any security for each trading day shall be the reported per share closing bid price
of such security regular way on the Stock Market on such trading day, or, if there were no transactions on such trading day, the average of the reported closing bid and asked prices, regular way, of such security on the relevant Stock Market on such
trading day. 

 (ii) “Fair Market Value” of any asset (including any security) means
the fair market value thereof as mutually determined by the Corporation and the holders of a majority of the Series A Preferred Stock then outstanding. If the Corporation and the holders of a majority of the Series A Preferred Stock then outstanding
are unable to reach agreement on any valuation matter, such valuation shall be submitted to and determined by a nationally recognized independent investment bank selected by the Board of Directors and the holders of a majority of the Series A
Preferred Stock then outstanding (or, if such selection cannot be agreed upon promptly, or in any event within ten days, then such valuation shall be made by a nationally recognized independent investment banking firm selected by the American
Arbitration Association in New York City in accordance with its rules), the costs of which valuation shall be paid for by the Corporation. 

(iii) “Market Price” shall mean the average Closing Bid Price for twenty (20) consecutive trading days, ending
with the trading day prior to the date as of which the Market Price is being determined (with appropriate adjustments for subdivisions or combinations of shares effected during such period), provided that if the prices referred to in the definition
of Closing Bid Price cannot be determined on any trading day, the Closing Bid Price for such trading day will be deemed to equal Fair Market Value of such security on such trading day. 

(iv) “Registered Holders” shall mean, at any time, the holders of record of the Series A Preferred Stock. 

(v) The “Stock Market” shall mean, with respect to any security, the principal national securities exchange on which
such security is listed or admitted to trading or, if such security is not listed or admitted to trading on any national securities exchange, shall mean The Nasdaq National Market System (“NNM”) or The Nasdaq SmallCap Market
(“SCM” and, together with NNM, “Nasdaq”) or, if such security is not quoted on Nasdaq, shall mean the OTC Bulletin Board or, if such security is not quoted on the OTC Bulletin Board, shall mean the
over-the-counter market as furnished by any NASD member firm selected from time to time by the Corporation for that purpose. 

(vi) A “trading day” shall mean a day on which the relevant Stock Market is open for the transaction of business.

 2. Dividends and Distributions. (a) The holders, as of the Dividend Record Date (as defined below), of the Series A Preferred
Stock shall be entitled to receive semi-annual dividends on their respective shares of Series A Preferred Stock (aggregating, for this purpose, all shares of Series A Preferred Stock held of record or, to the Corporation’s knowledge,
beneficially by such holder), payable, at the option of the Corporation, in cash or additional shares of Series A Preferred Stock, at the rate of 6.5% per annum (computed on the basis of a 360-day year of
twelve 30 day months) of the Dividend Base Amount (as defined below), 

  
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payable semi-annually in arrears; provided that, to the extent the declaration or payment of such dividend is prohibited by applicable law, such dividend need not be paid but shall nevertheless
accrue and shall be paid promptly when applicable law permits. Such dividends shall accrue from the date of issuance of such share and shall be paid semi-annually on April 1 and October 1 of each year or, if any such day is not a business
day, on the next succeeding business day. Such dividends shall be paid, at the election of the Corporation, either in cash or additional duly authorized, fully paid and non assessable shares of Series A Preferred Stock. In calculating the number of
shares of Series A Preferred Stock to be paid with respect to each dividend, the Series A Preferred Stock shall be valued at $100.00 per share (subject to appropriate adjustment to reflect any stock split, combination, reclassification or
reorganization of the Series A Preferred Stock). Notwithstanding the foregoing, the Corporation shall not be required to issue fractional shares of Series A Preferred Stock; the Corporation may elect, in its sole discretion, independently for each
holder, whether such number of shares (on an aggregated basis) will be rounded to the nearest whole share (with .5 of a share rounded upward) or whether such holder will be given cash in lieu of any fractional shares. The “Dividend Base
Amount” of a share of Series A Preferred Stock shall be $100.00 plus all accrued but unpaid dividends (subject to appropriate adjustment to reflect any stock split, combination, reclassification or reorganization of the Series A Preferred
Stock). The “Dividend Record Date” shall mean, for each semi-annual dividend, the March 15 or September 15, as the case may be, immediately preceding the dividend payment date. 

(b) In addition to the foregoing, subject to the rights of the holders of any shares of any series or class of capital stock ranking prior, and
superior to, or pari passu with, the shares of Series A Preferred Stock with respect to dividends, the holders of shares of Series A Preferred Stock shall be entitled to receive, as, when and if declared by the Board of Directors, out of assets
legally available for that purpose, dividends or distributions in cash, stock or otherwise. 
 (c) The Corporation shall not declare any
dividend or distribution on any Junior Stock (as defined below) of the Corporation unless all dividends required by Section 2(a) have been or contemporaneously are declared and paid, or declared and a sum sufficient for the payment thereof set
apart for such payment, on the Series A Preferred Stock. 
 (d) [Reserved] 

(e) All dividends or distributions declared upon the Series A Preferred Stock shall be declared pro rata per share. 

(f) Any reference to “distribution” contained in this Section 2 shall not be deemed to include any distribution made in
connection with or in lieu of any Liquidation Event (as defined below). 
 (g) No interest, or sum of money in lieu of interest, shall be
payable in respect of any dividend payment or payments on the Series A Preferred Stock which may be in arrears (it being understood that this provision does not alter the Corporation’s obligations under Section 2(a)). 

  
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 (h) So long as any shares of the Series A Preferred Stock are outstanding, no dividends, except
as described in the next succeeding sentence, shall be declared or paid or set apart for payment on any class or series of stock of the Corporation ranking, as to dividends, on a parity with the Series A Preferred Stock, for any period unless all
dividends have been or contemporaneously are declared and paid, or declared and a sum sufficient for the payment thereof set apart for such payment, on the Series A Preferred Stock. When dividends are not paid in full or a sum sufficient for such
payment is not set apart, as aforesaid, upon the shares of the Series A Preferred Stock and any other class or series of stock ranking on a parity as to dividends with the Series A Preferred Stock, all dividends declared upon such other stock shall
be declared pro rata so that the amounts of dividends per share declared on the Series A Preferred Stock and such other stock shall in all cases bear to each other the same ratio that accrued dividends per share on the shares of the Series A
Preferred Stock and on such other stock bear to each other. 
 (i) So long as any shares of the Series A Preferred Stock are outstanding, no
other stock of the Corporation ranking on a parity with the Series A Preferred Stock as to dividends or upon liquidation, dissolution or winding up shall be redeemed, purchased or otherwise acquired for any consideration (or any moneys be paid to or
made available for a sinking fund or otherwise for the purchase or redemption of any shares of any such stock) by the Corporation unless the dividends, if any, accrued on all outstanding shares of the Series A Preferred Stock shall have been paid or
set apart for payment. 
 (j) “Junior Stock” shall mean the Common Stock and any shares of preferred stock of any series or class
of the Corporation, whether presently outstanding or hereafter issued, which are junior to the shares of Series A Preferred Stock with respect to (i) the distribution of assets on any voluntary or involuntary liquidation, dissolution or winding
up of the Corporation, (ii) dividends or (iii) voting. 
 3. Liquidation Preference. (a) In the event of a
(i) liquidation, dissolution or winding up of the Corporation, whether voluntary or involuntary, (ii) a sale or other disposition of all or substantially all of the assets of the Corporation or (iii) any consolidation, merger,
combination, reorganization or other transaction in which the Corporation is not the surviving entity or shares of Common Stock constituting in excess of 50% of the voting power of the Corporation are exchanged for or changed into stock or
securities of another entity, cash and/or any other property (a “Merger Transaction”) (items (i), (ii) and (iii) of this sentence being collectively referred to as a “Liquidation Event”), after payment or provision for
payment of debts and other liabilities of the Corporation, the holders of the Series A Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders, whether such
assets are capital, surplus, or earnings, before any payment or declaration and setting apart for payment of any amount shall be made in respect of any Junior Stock of the Corporation, an amount equal to the Dividend Base Amount at such time;
provided, however, in the case of a Merger Transaction, such payment may be made in cash, property (valued as provided in Subsection 3(b)) and/or securities (valued as provided in Subsection 3(b)) of the entity surviving such Merger Transaction. In
the case of property or in the event that any such securities are subject to an investment letter or other similar restriction on transferability, the value of such property or securities shall be determined by agreement between the Corporation and
the holders of a majority of the Series A Preferred Stock then outstanding. If upon any Liquidation Event, whether voluntary or involuntary, the assets to be distributed to 

  
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the holders of the Series A Preferred Stock shall be insufficient to permit the payment to such shareholders of the full preferential amounts aforesaid, then all of the assets of the Corporation
to be distributed shall be so distributed ratably to the holders of the Series A Preferred Stock on the basis of the number of shares of Series A Preferred Stock held. Notwithstanding item (iii) of the first sentence of this Subsection 3(a),
any consolidation, merger, combination, reorganization or other transaction in which the Corporation is not the surviving entity but the stockholders of the Corporation immediately prior to such transaction own in excess of 50% of the voting power
of the corporation surviving such transaction and own amongst themselves such interest in substantially the same proportions as prior to such transaction, shall not be considered a Liquidation Event provided that the surviving corporation shall make
appropriate provisions to ensure that the terms of this Certificate of Designation survive any such transaction. All shares of Series A Preferred Stock shall rank as to payment upon the occurrence of any Liquidation Event senior to the Common Stock
and, unless the terms of such series shall provide otherwise, senior to all other series of the Corporation’s preferred stock. 
 (b)
Any securities or other property to be delivered to the holders of the Series A Preferred Stock pursuant to Subsection 3(a) hereof shall be valued as follows: 

(i) Securities not subject to an investment letter or other similar restriction on free marketability: 

(A) If actively traded on a Stock Market, the per share value shall be deemed to be the Market Price of such securities as of
the third day prior to the date of valuation. 
 (B) If not actively traded on a Stock Market, the value shall be the Fair
Market Value of such securities. 
 (ii) For securities for which there is an active public market but which are subject to
an investment letter or other restrictions on free marketability, the value shall be the Fair Market Value thereof, determined by discounting appropriately the per share Market Price thereof. 

(iii) For all other securities, the value shall be the Fair Market Value thereof. 

4. Conversion. 
 (a)
Right of Conversion. Commencing after the expiration of 12 months following the Alternative Equity Closing Date (as hereinafter defined), but not prior thereto, the shares of Series A Preferred Stock shall be convertible, in whole or in part,
at the option of the holder thereof and upon notice to the Corporation as set forth in Subsection 4(b), into fully paid and nonassessable shares of Common Stock and such other securities and property as hereinafter provided. The initial conversion
price per share of Common Stock (the “Conversion Price”), shall be equal to the product of 2.125 multiplied by the per share price (the “Stated Common Price”) of Common Stock sold by the Corporation in connection with the
Alternative Equity Offering (as such term is defined in the Corporation’s Offer to Exchange dated February 6, 1998 (the “Original Offer to Exchange”), as amended by the Amendment thereto (the “Amendment”)

  
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dated March 30, 1998 (collectively, the “Offer to Exchange”)) and shall be subject to adjustment as provided herein. The rate at which each share Series A Preferred Stock is
convertible at any time into Common Stock (the “Conversion Rate”) shall be determined by dividing the then existing Conversion Price (determined in accordance with this Section 4, including the last paragraph hereof) into the Dividend
Base Amount. 
 The Corporation shall prepare a certificate signed by the Chairman or President, and by the Treasurer or an Assistant
Treasurer or the Secretary or an Assistant Secretary, of the Corporation setting forth the Conversion Rate as of the date of the closing of the Alternative Equity Offering (the “Alternative Equity Closing Date”), showing in reasonable
detail the facts upon which such Conversion Rate is based, and such certificate shall forthwith be filed with the transfer agent of the Series A Preferred Stock. 

(b) Conversion Procedures. Any holder of shares of Series A Preferred Stock desiring to convert such shares into Common Stock shall
surrender the certificate or certificates evidencing such shares of Series A Preferred Stock at the office of the transfer agent for the Series A Preferred Stock, which certificate or certificates, if the Corporation shall so require, shall be duly
endorsed to the Corporation or in blank, or accompanied by proper instruments of transfer to the Corporation or in blank, accompanied by irrevocable written notice to the Corporation that the holder elects so to convert such shares of Series A
Preferred Stock and specifying the name or names (with address) in which a certificate or certificates evidencing shares of Common Stock are to be issued. The Corporation need not deem a notice of conversion to be received unless the holder complies
with all the provisions hereof. The Corporation will instruct the transfer agent (which may be the Corporation) to make a notation of the date that a notice of conversion is received, which date of receipt shall be deemed to be the date of receipt
for purposes hereof. 
 The Corporation shall, as soon as practicable after such deposit of certificates evidencing shares of Series A
Preferred Stock accompanied by the written notice and compliance with any other conditions herein contained, deliver at such office of such transfer agent to the person for whose account such shares of Series A Preferred Stock were so surrendered,
or to the nominee or nominees of such person, certificates evidencing the number of full shares of Common Stock to which such person shall be entitled as aforesaid, subject to Section 4(d). Subject to the following provisions of this paragraph,
such conversion shall be deemed to have been made as of the date of such surrender of the shares of Series A Preferred Stock to be converted, and the person or persons entitled to receive the Common Stock deliverable upon conversion of such Series A
Preferred Stock shall be treated for all purposes as the record holder or holders of such Common Stock on such date; provided, however, that the Corporation shall not be required to convert any shares of Series A Preferred Stock while the stock
transfer books of the Corporation are closed for any purpose, but the surrender of Series A Preferred Stock for conversion during any period while such books are so closed shall become effective for conversion immediately upon the reopening of such
books as if the surrender had been made on the date of such reopening, and the conversion shall be at the conversion rate in effect on such date. No adjustments in respect of any dividends on shares surrendered for conversion or any dividend on the
Common Stock issued upon conversion shall be made upon the conversion of any shares of Series A Preferred Stock. 

  
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 The Corporation shall at all times, reserve and keep available out of its authorized but unissued
shares of Common Stock, solely for the purpose of effecting the conversion of the shares of Series A Preferred Stock, such number of shares of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares
of the Series A Preferred Stock. 
 All notices of conversion shall be irrevocable; provided, however, that if the Corporation has
sent notice of an event pursuant to Subsection 4(g) hereof, a holder of Series A Preferred Stock may, at its election, provide in its notice of conversion that the conversion of its shares of Series A Preferred Stock shall be contingent upon the
occurrence of the record date or effectiveness of such event (as specified by such holder), provided that such notice of conversion is received by the Corporation prior to such record date or effective date, as the case may be. 

(c) Adjustment of Conversion Rate and Conversion Price. 

(i) As used in this Subsection 4(c), the following terms shall have the following meanings: 

“Capital Stock” of any Person means the Common Stock or Preferred Stock of such Person. Unless otherwise
stated herein or the context otherwise requires, “Capital Stock” means Capital Stock of the Corporation; 

“Common Stock” of any Person other than the Corporation means the common equity (however designated),
including, without limitation, common stock or partnership or membership interests of, or participation or interests in such Person (or equivalents thereof). “Common Stock” of the Corporation means the Common Stock, par value $.001
per share, of the Corporation, any successor class or classes of common equity (however designated) of the Corporation into or for which such Common Stock may hereafter be converted, exchanged or reclassified and any class or classes of common
equity (however designated) of the Corporation which may be distributed or issued with respect to such Common Stock or successor class of classes to holders thereof generally. Unless otherwise stated herein or the context requires otherwise,
“Common Stock” means Common Stock of the Corporation; 
 “Current Market Price” means, when
used with respect to any security as of any date, the last sale price, regular way, or, in case no such sale takes place on such date, the average of the closing bid and asked prices, regular way, of such security in either case as reported for
consolidated transactions on the New York Stock Exchange or, if such security is not listed or admitted to trading on the New York Stock Exchange, as reported for consolidated transactions with respect to securities listed on the principal national
securities exchange on which such security is listed or admitted to trading or, if such security is not listed or admitted to trading on any national securities exchange, as reported on the Nasdaq National Market, or, if such security is not listed
or admitted to trading on the Nasdaq National Market, as reported on the Nasdaq SmallCap Market, or if such security is not listed or admitted to trading on any national securities exchange or the 

  
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Nasdaq National Market or the Nasdaq SmallCap Market, the average of the high bid and low asked prices of such security in the
over-the-counter market, as reported by the National Association of Securities Dealers, Inc. Automated Quotations System or such other system then in use or, if such
security is not quoted by any such organization, the average of the closing bid and asked prices of such security furnished by an NASD member firm selected by the Corporation. If such security is not quoted by any such organization and no such NASD
member firm is able to provide such prices, the Current Market Price of such security shall be the Fair Market Value thereof; 

“Fair Market Value” means, at any date as to any asset, Property or right (including without limitation,
Capital Stock of any Person, evidence of indebtedness or other securities, but excluding cash), the fair market value of such item as determined in good faith by the Board of Directors, whose determination shall be conclusive; provided, however,
that such determination is described in an Officers’ Certificate filed with the transfer agent and that, if there is a Current Market Price for such item on such date, “Fair Market Value” means such Current Market Price
(without giving effect to the last sentence of the definition thereof); 
 “GAAP” means, as of any date,
generally accepted accounting principles in the United States and does not include any interpretations or regulations that have been proposed but that have not become effective; 

“Officer” means, with respect to any Person, the Chairman of the Board, the Chief Executive Officer, the
President, the Chief Operating Officer, the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller, the Secretary, any Assistant Secretary or any Vice President of such Person; 

“Officers’ Certificate” means a certificate signed on behalf of the Corporation by two Officers, one of
whom must be the Chairman of the Board, the President, the Treasurer or a Vice-President of the Corporation; 

“Person” means any individual, corporation, partnership, association, trust or any other entity or
organization, including a government or political subdivision or any agency or instrumentality thereof; 
 “Preferred
Stock” of any Person means the class or classes of equity, ownership or participation interests (however designated) in such Person, including, without limitation, stock, share, partnership and membership interests, which are preferred as
to the payment of dividends or distributions by, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of, such Person (or equivalent thereof) over interests of any other class of interests of such Person.
Unless otherwise stated herein or the context otherwise requires, “Preferred Stock” means Preferred Stock of the Corporation; 

“Property” of any Person means any and all types of real, personal, tangible, intangible or mixed property
owned by such Person whether or not included on the most recent consolidated balance sheet of such Person in accordance with GAAP; 

  
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 “Subsidiary” of a Person on any date means any other Person of
whom such Person owns, directly or indirectly through a Subsidiary or Subsidiaries of such Person, Capital Stock with voting power, acting independently and under ordinary circumstances, entitling such person to elect a majority of the board of
directors or other governing body of such other Person. Unless otherwise stated herein or the context otherwise requires, “Subsidiary” means a Subsidiary of the Corporation. 

(ii) If the Corporation shall (i) pay a dividend or other distribution, in Common Stock, on any class of Capital Stock of
the Corporation, (ii) subdivide the outstanding Common Stock into a greater number of shares by any means or (iii) combine the outstanding Common Stock into a smaller number of shares by any means including, without limitation, a reverse
stock split), then in each such case the Conversion Price in effect immediately prior thereto shall be adjusted so that the Registered Holder of any shares of Series A Preferred Stock thereafter surrendered for conversion shall be entitled to
receive the number of shares of Common Stock that such Registered Holder would have owned or have been entitled to receive upon the happening of such event had such Series A Preferred Stock been converted immediately prior to the relevant record
date or, if there is no such record date, the effective date of such event. An adjustment made pursuant to this Paragraph 4(c)(ii) shall become effective immediately after the record date for the determination of stockholders entitled to receive
such dividend or distribution and shall become effective immediately after the effective date of such subdivision or combination, as the case may be. 

(iii) If the Corporation shall (i) issue or distribute (at a price per share less than the Current Market Price per share
of such Capital Stock on the date of such issuance or distribution) Capital Stock generally to holders of Common Stock or to holders of any class or series of Capital Stock which is convertible into or exchangeable or exercisable for Common Stock
(excluding an issuance or distribution of Common Stock described in Paragraph 4(c)(ii)) or (ii) issue or distribute generally to such holders rights, warrants, options or convertible or exchangeable securities entitling the holder thereof to
subscribe for, purchase, convert into or exchange for Capital Stock at a price per share less than the Current Market Price per share of such Capital Stock on the date of issuance or distribution, then, in each such case, at the earliest of
(A) the date the Corporation enters into a firm contract for such issuance or distribution, (B) the record date for the determination of stockholders entitled to receive any such Capital Stock or any such rights, warrants, options or
convertible or exchangeable securities or (C) the date of actual issuance or distribution of any such Capital Stock or any such rights, warrants, options or convertible or exchangeable securities, the Conversion Price shall be reduced by
multiplying the Conversion Price in effect immediately prior to such earliest date by: 

  
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 (A) if such Capital Stock is Common Stock, a fraction the numerator of which is
the number of shares of Common Stock outstanding, on such earliest date plus the number of shares of Common Stock which could be purchased at the Current Market Price per share of Common Stock on the date of such issuance or distribution with the
aggregate consideration (based on the Fair Market Value thereof) received or receivable by the Corporation either (A) in connection with such issuance or distribution or (B) upon the conversion, exchange, purchase or subscription of all
such rights, warrants, options or convertible or exchangeable securities (the “Aggregate Consideration”), and the denominator of which is the number of shares of Common Stock outstanding on such earliest date plus the number of
shares of Common Stock to be so issued or distributed or to be issued upon the conversion, exchange, purchase or subscription of all such rights, warrants, options or convertible or exchangeable securities; or 

(B) if such Capital Stock is other than Common Stock, a fraction the numerator of which is the Current Market Price per share
of Common Stock on such earliest date minus an amount equal to (A) the difference between (1) the Current Market Price per share of such Capital Stock multiplied by the number of shares of such Capital Stock to be so issued and
(2) the Aggregate Consideration, divided by (B) the number of shares of Common Stock outstanding on such date, and the denominator of which is the Current Market Price per share of Common Stock on such earliest date. 

Such adjustment shall be made successively whenever any such Capital Stock, rights, warrants, options or convertible or exchangeable securities
are so issued or distributed. In determining whether any rights, warrants, options or convertible or exchangeable securities entitle the holders thereof to subscribe for, purchase, convert into or exchange for shares of such Capital Stock at less
than such Current Market Price, there shall be taken into account the Fair Market Value of any consideration received or receivable by the Corporation for such rights, warrants, options or convertible or exchangeable securities. If any right,
warrant, option or convertible or exchangeable security, the issuance of which resulted in an adjustment in the Conversion Price pursuant to this Paragraph 4(c)(iii), shall expire and shall not have been exercised, the Conversion Price shall
immediately upon such expiration be recomputed to the Conversion Price which would have been in effect if such right, warrant, option or convertible or exchangeable securities had never been distributed or issued. Notwithstanding anything contained
in this paragraph to the contrary, (i) the issuance of Capital Stock upon the exercise of such rights, warrants or options or the conversion or exchange of such convertible or exchangeable securities will not cause an adjustment in the
Conversion Price if no such adjustment would have been required at the time such right, warrant, option or convertible or exchangeable security was issued or distributed; provided, however, that, if the consideration payable upon such
exercise, conversion or exchange and/or the Capital Stock receivable thereupon 

  
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are changed after the time of the issuance or distribution of such right, warrant, option or convertible or exchangeable security then such change shall be deemed to be the expiration thereof
without having been exercised and the issuance or distribution of new options, rights, warrants or convertible or exchangeable securities and (ii) the issuance of convertible preferred stock of the Corporation as a dividend on convertible
preferred stock of the Corporation will not cause an adjustment in the Conversion Price if no such adjustment would have been required at the time such underlying convertible preferred stock was issued (or as a result of any subsequent modification
to the terms thereof) and the conversion provisions of such convertible stock so issued as a dividend are the same as in such underlying convertible preferred stock. 

Notwithstanding any contained in this Certificate of Designation to the contrary, options, rights or warrants issued or
distributed by the Corporation, including options, rights or warrants distributed prior to the date of filing of this Certificate of Designation, to holders of Common Stock generally which, until the occurrence of a specified event or events (a
“Trigger Event”), (i) are deemed to be transferred with Common Stock, (ii) are not exercisable and (iii) are also issued on a pro rata basis with respect to future issuances of Common Stock, shall be deemed not to
have been issued or distributed for purposes of this Subsection 4(c) (and no adjustment to the Conversion Price under this Subsection 4(c) will be required) until the occurrence of the earliest Trigger Event. Upon the occurrence of a Trigger Event,
such options, rights or warrants shall continue to be deemed not to have been issued or distributed for purposes of this Subsection 4(c) (and no adjustment to the Conversion Price under this Subsection 4(c) will be required) if and for so long as
each Registered Holder who thereafter converts such Registered Holder’s Series A Preferred Stock shall be entitled to receive upon such conversion, in addition to the shares of Common Stock issuable upon such conversion, a number of such
options, rights or warrants, as the case may be, equal to the number of options, rights or warrants to which a holder of the number of shares of Common Stock equal to the number of shares of Common Stock issuable upon conversion of such Registered
Holder’s Series A Preferred Stock is entitled to receive at the time of such conversion in accordance with the terms and provisions of, and applicable to, such options, rights or warrants. Upon the expiration of any such options, rights or
warrants or at such time, if any, as a Registered Holder is not entitled to receive such options, rights or warrants upon conversion of such Registered Holder’s Series A Preferred Stock, an adjustment (if any is required) to the Conversion
Price shall be made in accordance with this Paragraph 4(c)(iii) with respect to the issuance of all such options, rights and warrants as of the date of issuance thereof, but subject to the provisions of the preceding paragraph, if any such option,
right or warrant, including any such options right or warrants distributed prior to the date of filing of this Certificate of Designation, are subject to events, upon the occurrence of which such options, rights or warrants become exercisable to
purchase different securities, evidence of indebtedness, cash, Properties or other assets or different amounts thereof, then, subject to the preceding provision of this paragraph, the date of the occurrence of any and each such event shall be deemed
to be the date of distribution and record 

  
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date with respect to new options, right or warrants with such new purchase rights (and a termination or expiration of the existing options, rights or warrants without exercise thereof). In
addition, in the event of any distribution (or deemed distribution) of options, rights or warrants, or any Trigger Event or other event of the type described in the preceding sentence, that required (or would have required but for the provisions of
Paragraph 4(c)(vi) or this paragraph) an adjustment to the Conversion Price under this Subsection 4(c) and such options, rights or warrants shall thereafter have been redeemed or repurchased without having been exercised, then the Conversion Price
shall be adjusted upon such redemption or repurchase to give effect to such distribution, Trigger Event or other event, as the case may, as though it had instead been a cash distribution, equal on a per share basis to the result of the aggregate
redemption or repurchase price received by holders of such options, rights or warrants divided by the number of shares of Common Stock outstanding as of the date of such repurchase or redemption, made to holders of Common Stock generally as of the
date of such redemption or repurchase. 
 (iv) If the Corporation shall pay or distribute, as a dividend or otherwise,
generally to holders of Common Stock or any class or series of Capital Stock which is convertible into or exercisable or exchangeable for Common Stock any assets, Properties or rights (including, without limitation, evidences of indebtedness of the
Corporation, any Subsidiary or any other Person, cash or Capital Stock or other securities of the Corporation, any Subsidiary or any other Person, but excluding payments and distributions as described in Paragraphs 4(c)(ii) or (iii), dividends and
distributions in connection with a Liquidation Event and distributions consisting solely of cash described in Paragraph 4(c)(v)), then in each such case the Conversion Price shall be reduced by multiplying the Conversion Price in effect immediately
prior to the date of such payment or distribution by a fraction, the numerator of which is the Current Market Price per share of Common Stock on the record date for the determination of stockholders entitled to receive such payment or distribution
less the Fair Market Value per share of Common Stock on such record date of the assets, Properties or rights so paid or distributed, and the denominator of which is the Current Market Price per share of Common Stock on such record date. Such
adjustment shall become effective immediately after such record date. For purposes of this Paragraph 4(c)(iv), such Fair Market Value per share shall equal the aggregate Fair Market Value on such record date of the assets, Properties or rights so
paid or distributed divided by the number of shares of Common Stock outstanding on such record date. For all purposes of this Certificate of Designation, adjustments to any security’s conversion or exercise price pursuant to such
security’s original terms shall not be deemed a distribution or dividend to holders thereof. 
 (v) If the Corporation
shall, by dividend or otherwise, make a distribution (other than in connection with the liquidation, dissolution or winding up of the Corporation in its entirety), generally to holders of Common Stock or any class or series of Capital Stock which is
convertible into or exercisable or exchangeable for Common Stock, consisting solely of cash where (x) the sum of (i) the 

  
 - 12 - 

 
aggregate amount for such cash plus (ii) the aggregate amount of all cash so distributed (by dividend or otherwise) to such holders within the
12-month period ending on the record date for determining stockholder entitled to receive such distribution with respect to which no adjustment has been made to the Conversion Price pursuant to this Paragraph
4(c)(v) exceeds (y) 10% of the result of the multiplication of (1) the Current Market Price per share of Common Stock on such record date times (2) the number of shares of Common Stock outstanding on such record date, then the
Conversion Price shall be reduced, effective immediately prior to the opening of business on the day following such record date, by multiplying the Conversion Price in effect immediately prior to the close of business on the day prior to such record
date by a fraction, the numerator of which is the Current Market Price per share of Common Stock on such record date less the aggregate amount of cash per share so distributed and the denominator of which is such Current Market Price; provided,
however, that, if the aggregate amount of cash per share is equal to or greater than such Current Market Price, then, in lieu of the foregoing adjustment, adequate provisions shall be made so that each Registered Holder shall have the right to
receive upon conversion (with respect to each share of Common Stock issued upon such conversion and in addition to the Common Stock issuable upon conversion) the aggregate amount of cash per share such Registered Holder would have received had such
Registered Holder’s Series A Preferred Stock been converted immediately prior to such record date. In no event shall the Conversion Price be increased pursuant to this Paragraph 4(c)(v); provided, however, that if such distribution is
not so made, the Conversion Price shall be adjusted to be the Conversion Price which would have been in effect if such distribution had not been declared. For purposes of this Paragraph 4(c)(v), such aggregate amount of cash per share shall equal
such sum divided by the number of shares of Common Stock outstanding on such record date. 
 (vi) The provisions of this
Subsection 4(c) shall similarly apply to all successive events of the type described in this Subsection 4(c). Notwithstanding anything contained herein to the contrary, no adjustment in the Conversion Price shall be required unless such adjustment
would require an increase or decrease of at least 1% in the Conversion Price then in effect; provided, however, that any adjustments which by reason of this Paragraph 4(c)(vi) are not required to be made shall be carried forward and taken
into account in any subsequent adjustment. All calculations under this Section 4 shall be made by the Corporation and shall be made to the nearest cent or to the nearest one hundredth of a share, as the case may be, and the transfer agent shall
be entitled to rely conclusively thereon. Except as provided in this Section 4, no adjustment in the Conversion Price will be made for the issuance of Common Stock or any securities convertible into or exchangeable for Common Stock or carrying
the right to purchase Common Stock or any securities so convertible or exchangeable. 
 (vii) Whenever the Conversion Price
is adjusted as provided herein, the Corporation shall promptly file with the transfer agent an Officers’ Certificate setting forth the Conversion Price in effect after such adjustment and setting forth

  
 - 13 - 

 
a brief statement of the facts requiring such adjustment. Promptly after delivery of such Officers’ Certificate, the Corporation shall give or cause to be given to each Registered Holder a
notice of such adjustment of the Conversion Price setting forth the adjusted Conversion Price and the date on which such adjustment becomes effective. 

(viii) Notwithstanding anything contained herein to the contrary, in any case in which this Subsection 4(c) provides that an
adjustment in the Conversion Price shall become effective immediately after a record date for an event, the Corporation may defer until the occurrence of such event (i) issuing to the Registered Holder of any Series A Preferred Stock converted
after such record date and before the occurrence of such event the additional shares of Common Stock issuable upon such conversion by reason of the adjustment required by such event over and above the number of shares of Common Stock issuable upon
such conversion before giving effect to such adjustment and (ii) paying to such Registered Holder any amount in cash in lieu of any fractional share of Common Stock pursuant to Subsection 4(d). 

(ix) Notwithstanding any other provision hereof, no adjustment to the Conversion Price shall be made upon the issuance or
exercise or conversion of (1) options or warrants to purchase, in the aggregate, up to 25% of the securities sold in the offerings of securities of the Corporation described in the Original Offer to Exchange or any options or warrants described
in the Amendment in respect of the Alternative Equity Offering, in each case issued to (or to the designee of) any placement agent or financial advisor (such options or warrants, the “Offering Warrants”), (2) any equity securities or
warrants of the Corporation (including, without limitation, the Series A Preferred Stock, warrants and equity securities underlying warrants) issued in exchange for 9% Convertible Subordinated Notes due 2004 (the “9% Notes”) of the
Corporation or accrued interest thereon or pursuant to the conversion or exercise provisions thereof, (3) any warrants issued in connection with the offerings described in the Original Offer to Exchange or the Amendment (collectively, the
“Offering”), (4) any warrants issued to Forum Capital Markets, LLC (“Forum”) in exchange for or in addition to, or any amendment to, any warrants held by Forum, in each case, pursuant to a letter agreement dated
January 5, 1998, between the Corporation and Forum, and any other warrants to purchase Common Stock or shares of Common Stock issued to Forum or its designee, (5) any Series A Preferred Stock issued in the Offering, (6) any Capital
Stock issued or cash paid as dividends on the Series A Preferred Stock or (7) any Capital Stock issued or cash paid upon the mandatory conversion or redemption of any Series A Preferred Stock in accordance with Section 5 of this
Certificate of Designation. 
 (d) No Fractional Shares. No fractional shares or scrip representing fractional shares of Common Stock
shall be issued upon conversion of Series A Preferred Stock. If more than one certificate evidencing shares of Series A Preferred Stock shall be surrendered for conversion at one time by the same holder, the number of full shares issuable upon
conversion thereof shall be computed on the basis of the aggregate number of shares of Series A Preferred 

  
 - 14 - 

 
Stock so surrendered. Instead of any fractional share of Common Stock which would otherwise be issuable upon conversion of such aggregate number of shares of Series A Preferred Stock, the
Corporation may elect, in its sole discretion, independently for each holder, whether such number of shares of Common Stock will be rounded to the nearest whole share (with a .5 of a share rounded upward) or whether such holder will be given cash,
in lieu of any fractional share, in an amount equal to the same fraction of the Market Price of the Common Stock as of the close of business on the day of conversion. 

(e) [Reserved] 
 (f)
Reservation of Shares; Transfer Taxes, Etc. The Corporation shall at all times reserve and keep available, out of its authorized and unissued shares of Common Stock, solely for the purpose of effecting the conversion of the Series A Preferred
Stock, such number of shares of its Common Stock free of preemptive rights as shall be sufficient to effect the conversion of all shares of Series A Preferred Stock from time to time outstanding. The Corporation shall use its best efforts from time
to time, in accordance with the laws of the State of Delaware to increase the authorized number of shares of Common Stock if at any time the number of shares of authorized, unissued and unreserved Common Stock shall not be sufficient to permit the
conversion of all the then-outstanding shares of Series A Preferred Stock. 
 The Corporation shall pay any and all issue or other taxes
(excluding any income taxes) that may be payable in respect of any issue or delivery of shares of Common Stock on conversion of the Series A Preferred Stock. The Corporation shall not, however, be required to pay any tax which may be payable in
respect of any transfer involved in the issue or delivery of Common Stock (or other securities or assets) in a name other than that in which the shares of Series A Preferred Stock so converted were registered, and no such issue or delivery shall be
made unless and until the person requesting such issue has paid to the Corporation the amount of such tax or has established, to the satisfaction of the Corporation, that such tax has been paid or need not be paid. 

(g) Prior Notice of Certain Events. In case: 

(i) the Corporation shall declare any dividend (or any other distribution); or 

(ii) the Corporation shall authorize the granting to the holders of Common Stock of rights or warrants to subscribe for or
purchase any shares of stock of any class or of any other rights or warrants; or 
 (iii) of any reclassification of Common
Stock (other than a subdivision or combination of the outstanding Common Stock, or a change in par value, or from par value to no par value, or from no par value to par value); or 

(iv) of any consolidation or merger to which the Corporation is a party and for which approval of any stockholders of the
Corporation shall be required, or of the sale or transfer of all or substantially all of the assets of the Corporation or of any compulsory share exchange whereby the Common Stock is converted into other securities, cash or other property; or 

  
 - 15 - 

 (v) of any Liquidation Event; 

then the Corporation shall cause to be filed with the transfer agent for the Series A Preferred Stock, and shall cause to be mailed to the Registered Holders,
at their last addresses as they shall appear upon the stock transfer books of the Corporation, at least 20 days prior to the applicable record date hereinafter specified, a notice stating (x) the date on which a record (if any) is to be taken
for the purpose of such dividend. distribution or granting of rights or warrants or, if a record is not to be taken, the date as of which the holders of Common Stock of record to be entitled to such dividend, distribution, rights or warrants are to
be determined and a description of the cash, securities or other property to be received by such holders upon such dividend, distribution or granting of rights or warrants or (y) the date on which such reclassification, consolidation, merger,
sale, transfer, share exchange or Liquidation Event is expected to become effective, the date as of which it is expected that holders of Common Stock of record shall be entitled to exchange their shares of Common Stock for securities or other
property deliverable upon such exchange or Liquidation Event and the consideration, including securities or other property, to be received by such holders upon such exchange; provided, however, that no failure to mail such notice or any
defect therein or in the mailing thereof shall affect the validity of the corporate action required to be specified in such notice. 
 (h)
Other Changes in Conversion Rate. The Corporation from time to time may increase the Conversion Rate by any amount for any period of time if the period is at least 20 days and if the increase is irrevocable during the period. Whenever the
Conversion Rate is so increased, the Corporation shall mail to the Registered Holders a notice of the increase at least 15 days before the date the increased Conversion Rate takes effect, and such notice shall state the increased Conversion Rate and
the period it will be in effect. 
 The Corporation may make such increases in the Conversion Rate, in addition to those required or allowed
by this Section 4, as shall be determined by it, as evidenced by a resolution of the Board of Directors, to be advisable in order to avoid or diminish any income tax to holders of Common Stock resulting from any dividend or distribution of
stock or issuance of rights or warrants to purchase or subscribe for stock or from any event treated as such for income tax purposes. 

Notwithstanding anything to the contrary herein, in no case shall the Conversion Price be adjusted to an amount less than $.001 per share, the
current par value of the Common Stock into which the Series A Preferred Stock is convertible. 
 (i) Ambiguities/Errors. The Board of
Directors of the Corporation shall have the power to resolve any ambiguity or correct any error in the provisions relating to the convertibility of the Series A Preferred Stock, and its actions in so doing shall be final and conclusive. 

5. Mandatory Conversion and Redemption. (a) At any time after the expiration of 12 months after the Alternative Equity Closing
Date, the Corporation at its option, may cause the Series A Preferred Stock to be converted in whole or in part, on a pro rata basis, into fully paid and nonassessable shares of Common Stock using a conversion price equal to 200% of the
Stated Common Price if the Closing Bid Price (or, if the price referenced in the 

  
 - 16 - 

 
definition of Closing Bid Price cannot be determined, the Fair Market Value) of the Common Stock shall have equalled or exceeded 250% of the Conversion Price for at least 20 trading days in any
30 consecutive trading day period ending three days prior to the date of notice of conversion (such event, the “Market Trigger”). Any shares of Series A Preferred Stock so converted shall be treated as having been surrendered by the holder
thereof for conversion pursuant to Section 4 on the date of such mandatory conversion (unless previously converted at the option of the holder). 

(b) At any time after April 1, 2000, the Corporation, at its option, may redeem the Series A Preferred Stock for cash equal to the
Dividend Base Amount at such time, if the Market Trigger has occurred in the period ending three days prior to the date of notice of redemption (unless previously converted at the option of the holder). 

(c) No greater than 60 nor fewer than 20 days prior to the date of any such mandatory conversion or redemption, notice by first class mail,
postage prepaid, shall be given to the holders of record of the Series A Preferred Stock to be converted or redeemed, addressed to such holders at their last addresses as shown on the stock transfer books of the Corporation. Each such notice shall
specify the date fixed for conversion or redemption, the place or places for surrender of shares of Series A Preferred Stock and the then effective Conversion Rate pursuant to Section 4. 

Any notice which is mailed as herein provided shall be conclusively presumed to have been duly given by the Corporation on the date deposited
in the mail, whether or not the holder of the Series A Preferred Stock receives such notice; and failure properly to give such notice by mail, or any defect in such notice, to the holders of the shares to be converted or redeemed shall not affect
the validity of the proceedings for the conversion or redemption of any other shares of Series A Preferred Stock. On or after the date fixed for conversion or redemption (the “Take-Out Date”) as
stated in such notice, each holder of shares called to be converted or redeemed shall surrender the certificate evidencing such shares to the Corporation at the place designated in such notice for conversion or redemption. After the mailing of such
notice, but before the Take-Out Date as stated therein, all rights whatsoever with respect to the shares so called for conversion or redemption (except the right of the holders to convert such shares pursuant
to Section 4 and to have such shares converted or redeemed, as the case may be, upon surrender of their certificates therefor, pursuant to this Section 5) shall terminate. On or after the Take-Out
Date, notwithstanding that the certificates evidencing any shares properly called for conversion or redemption shall not have been surrendered, such shares shall no longer be deemed outstanding and all rights whatsoever with respect to the shares so
called for conversion or redemption (except the right of the holders to have such shares converted or redeemed, as the case may be, upon surrender of their certificates therefor, pursuant to this Section 5) shall terminate. 

6. Outstanding Shares. For purposes of this Certificate of Designation, a share of Series A Preferred Stock, when issued, shall be
deemed outstanding except (i) from the date, or the deemed date, of surrender of certificates evidencing shares of Series A Preferred Stock, all shares of Series A Preferred Stock converted into Common Stock or redeemed pursuant to
Section 5 and (ii) from the date of registration of transfer, all shares of Series A Preferred Stock held of record by the Corporation or any subsidiary of the Corporation. 

  
 - 17 - 

 7. Class Voting Rights. The Corporation shall not, without the affirmative vote or consent
of the holders of at least 50% of all outstanding Series A Preferred Stock, voting separately as a class, (i) amend, alter or repeal any provision of the Certificate of Incorporation or the Bylaws of the Corporation so as adversely to affect
the relative rights, preferences, qualifications, limitations or restrictions of the Series A Preferred Stock (it being understood that the issuance of securities ranking prior to, or pari passu with, the Series A Preferred Stock
(A) upon a Liquidation Event or (B) with respect to the payment of dividends or distributions shall not be considered adversely to affect such relative rights, preferences, qualifications, limitations or restrictions); or
(ii) authorize or issue, or increase the authorized amount of, Series A Preferred Stock, other than Series A Preferred Stock issuable in connection with the Offering, issuable in exchange for 9% Notes or accrued interest thereon or issuable as
dividends on Series A Preferred Stock. 
 8. Status of Acquired Shares. Shares of Series A Preferred Stock received upon conversion
or redemption pursuant to Section 4 or Section 5 or otherwise acquired by the Corporation will be restored to the status of authorized but unissued shares of Preferred Stock, without designation as to class, and may thereafter be issued,
but not as shares of Series A Preferred Stock. 
 9. Preemptive Rights. The Series A Preferred Stock is not entitled to any
preemptive or subscription rights in respect of any securities of the Corporation. 
 10. Severability of Provisions. Whenever
possible, each provision hereof shall be interpreted in a manner as to be effective and valid under applicable law, but if any provision hereof is held to be prohibited by or invalid under applicable law, such provision shall be ineffective only to
the extent of such prohibition or invalidity, without invalidating or otherwise adversely affecting the remaining provisions hereof. If a court of competent jurisdiction should determine that a provision hereof would be valid or enforceable if a
period of time were extended or shortened or a particular percentage were increased or decreased, then such court may make such changes as shall be necessary to render the provision in question effective and valid under applicable law. 

11. Restrictions on Change of Control. Notwithstanding anything to the contrary contained in this Certificate of Designation, without
the prior written consent of the Corporation, so long as any 9% Notes remain outstanding under that certain Indenture dated as of March 26, 1997 (as amended, the “Indenture”) in respect of the 9% Notes, no holder of Series A Preferred
Stock shall have voting rights granted hereunder, be entitled to receive any voting securities of the Corporation pursuant hereto or be entitled to exercise any of the conversion rights set forth herein (each, a “Restricted Event”), to the
extent that any such Restricted Event could, in the Corporation’s reasonable judgment, either alone or in conjunction with other issuances or holdings of capital stock, warrants or convertible securities of the Corporation, result in a Change
of Control (as defined in the Indenture). 
 [Signature page follows] 

  
 - 18 - 

 IN WITNESS WHEREOF, E. Andrews Grinstead, III, President and Chief Executive Officer of the
Corporation, acting for and on behalf of the Corporation, has hereunto subscribed his name this 5th day of May, 1998. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ E. Andrews Grinstead, III
		 	Name: E. Andrews Grinstead, III
		 	Title: President and Chief Executive Officer

  
 - 19 - 

 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF 

INCORPORATION 
 OF 

HYBRIDON, INC. 
 It is hereby certified that: 

1. The name of the corporation (hereinafter called the “Corporation”) is Hybridon, Inc. 

2. The Certificate of Incorporation of the Corporation is hereby amended by inserting a new sentence at the end of paragraph 4 of Subsection A
of Articles FOURTH thereof so that said paragraph as so amended shall read as follows: 
 “4. LIQUIDATION. Upon the
dissolution or liquidation of the Corporation, whether voluntary or involuntary, holders of Common Stock will be entitled to receive all assets of the Corporation available for distribution to its stockholders, subject to any preferential rights of
any then outstanding Preferred Stock. Notwithstanding the foregoing, and notwithstanding any amendments to, or resolutions of the Board of Directors in connection with, this Certificate of Incorporation, the transaction between the Corporation and
Boston Biosystems, Inc. pursuant to that certain Asset Purchase Agreement of June 29, 2000, shall not constitute a dissolution or liquidation of the Corporation such as would entitle any holder of the Series A Preferred Stock to a preferred
distribution.” 
 3. Paragraph 3 of the Certificate of Designation of the Corporation shall be amended by inserting a new sentence at
the end of the paragraph such that said paragraph shall read as follows: 
 “3(c) Notwithstanding the foregoing, and
notwithstanding any amendments to, or resolutions of the Board of Directors in connection with, this Certificate of Incorporation or Certificate of Designation, the transaction between the Corporation and Boston Biosystems, Inc. pursuant to that
certain Asset Purchase Agreement dated as of June 29, 2000, shall not constitute a Liquidation Event of the Corporation such as would entitle any holder of any series of Series A Preferred Stock to any preferred distribution.” 

4. Every other Article and provision in the Certificate of Incorporation of the Corporation remains in full force and effect. 

5. The amendment of the Certificate of Incorporation herein certified has been duly adopted in accordance with the provisions of
Section 242 of the General Corporation Law of the State of Delaware. 

 IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be duly signed by
its President this 19 day of September, 2000. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Robert G. Andersen
		 	 Robert G. Andersen, Vice President
 and
CFO

  
 - 2 - 

 CERTIFICATE OF DESIGNATION 

for 
 SERIES B CONVERTIBLE PREFERRED
STOCK 
 of 
 HYBRIDON, INC. 

Pursuant to Section 151 of the 

General Corporation Law of the State of Delaware 

HYBRIDON, INC., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), does hereby
certify that pursuant to the authority conferred on the board of directors of the Corporation (the “Board of Directors”) by the Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”) of the
Corporation and in accordance with Section 151 of the General Corporation Law of the State of Delaware, the Board of Directors adopted the following resolution establishing a series of 85,000 shares of preferred stock of the Corporation
designated as “Series B Convertible Preferred Stock”: 
 RESOLVED, that pursuant to the authority conferred on the
Board of Directors by the Certificate of Incorporation, a series of preferred stock, par value $.01 per share, of the Corporation is hereby established and created, and that the designation and number of shares thereof and the voting and other
powers, preferences and relative participating, optional or other special rights of, the shares of such series and the qualifications, limitations and restrictions thereof are as follows: 

Series B Convertible Preferred Stock 

1. Designation and Amount and Definitions. (a) There shall be a series of Preferred Stock designated as “Series B Convertible
Preferred Stock” and the number of shares constituting such series shall be 85,000. Such series is referred to herein as the “Series B Preferred Stock”. Notwithstanding any other provision in this Certificate of Designation of the
Series B Preferred Stock (the “Certificate of Designation”) to the contrary, such series shall be senior to the common stock, par value $.001 per share of the Corporation (the “Common Stock”), and the Series A Convertible
Preferred Stock, $.01 par value per share, of the Corporation (the “Series A Preferred Stock”), with respect to dividends and the distribution of assets upon liquidation, dissolution or winding up. Such number of shares may be increased or
decreased by resolution of the Board of Directors, subject to the provisions of Section 7 hereof; provided, however, that no decrease shall reduce the number of shares of Series B Preferred Stock to fewer than the number of shares then issued
and outstanding. 
 (b) As used in this Certificate of Designation, except as otherwise provided in Subsection 4(c), the following terms
shall have the following meanings: 
 (i) “Closing Bid Price” for any security for each trading day shall be the
reported per share closing bid price of such security regular way on the Stock Market on such trading day, or, if there were no transactions on such trading day, the average of the reported closing bid and asked prices, regular way, of such security
on the relevant Stock Market on such trading day. 

 (ii) “Fair Market Value” of any asset (including any security) means
the fair market value thereof as mutually determined by the Corporation and the holders of a majority of the Series B Preferred Stock then outstanding. If the Corporation and the holders of a majority of the Series B Preferred Stock then outstanding
are unable to reach agreement on any valuation matter, such valuation shall be submitted to and determined by a nationally recognized independent investment bank selected by the Board of Directors and the holders of a majority of the Series B
Preferred Stock then outstanding (or, if such selection cannot be agreed upon promptly, or in any event within ten (10) days, then such valuation shall be made by a nationally recognized independent investment banking firm selected by the
American Arbitration Association in New York City in accordance with its rules), the costs of which valuation shall be paid for by the Corporation. 

(iii) “Market Price” shall mean the average Closing Bid Price for twenty (20) consecutive trading days, ending
with the trading day prior to the date as of which the Market Price is being determined (with appropriate adjustments for subdivisions or combinations of shares effected during such period), provided that if the prices referred to in the definition
of Closing Bid Price cannot be determined on any trading day, the Closing Bid Price for such trading day will be deemed to equal Fair Market Value of such security on such trading day. 

(iv) “Registered Holders” shall mean, at any time, the holders of record of the Series B Preferred Stock. 

(v) “Stock Market” shall mean, with respect to any security, the principal national securities exchange on which such
security is listed or admitted to trading or, if such security is not listed or admitted to trading on any national securities exchange, shall mean The Nasdaq National Market System (“NNM”) or The Nasdaq SmallCap Market (“SCM”
and, together with NNM, “Nasdaq”) or, if such security is not quoted on Nasdaq, shall mean the OTC Bulletin Board or, if such security is not quoted on the OTC Bulletin Board, shall mean the over-the-counter market as furnished by any NASD member firm selected from time to time by the Corporation for that purpose. 

(vi) “Trading Day” shall mean a day on which the relevant Stock Market is open for the transaction of business. 

2. Dividends and Distributions. (a) The holders, as of the Dividend Record Date (as defined below), of the Series B Preferred Stock shall
be entitled to receive semi-annual dividends on their respective shares of Series B Preferred Stock (aggregating, for this purpose, all shares of Series B Preferred Stock held of record or, to the Corporation’s knowledge, beneficially by such
holder), payable, at the option of the Corporation, in cash or additional shares of Series B Preferred Stock, at the rate of 8% per annum (computed on the basis of a 360-day year of twelve 30 day months)
of the Dividend Base Amount (as defined below), payable semi-annually in arrears; provided that, to the extent the declaration or payment of such dividend is prohibited by applicable law, such dividend need not be paid but shall nevertheless accrue
and 

  
 - 2 - 

 
shall be paid promptly when applicable law permits. Such dividends shall accrue (i) from March 6, 2001 for shares of Series B Preferred Stock issued within thirty days of the date of
the filing of this Certificate of Designation, or (ii) from the date of issuance for shares of Series B Preferred Stock issued after thirty days from the date of filing of this Certificate of Designation, and shall be paid semi-annually on
April 1 and October 1 of each year or, if any such day is not a business day, on the next succeeding business day. Such dividends shall be paid, at the election of the Corporation, either in cash or additional duly authorized, fully paid
and non assessable shares of Series B Preferred Stock. In calculating the number of shares of Series B Preferred Stock to be paid with respect to each dividend, the Series B Preferred Stock shall be valued at $100.00 per share (subject to
appropriate adjustment to reflect any stock split, combination, reclassification or reorganization of the Series B Preferred Stock). Notwithstanding the foregoing, the Corporation shall not be required to issue fractional shares of Series B
Preferred Stock; the Corporation may elect, in its sole discretion, independently for each holder, whether such number of shares (on an aggregated basis) will be rounded to the nearest whole share (with .5 of a share rounded upward) or whether such
holder will be given cash in lieu of any fractional shares. The “Dividend Base Amount” of a share of Series B Preferred Stock shall be $100.00 plus all accrued but unpaid dividends (subject to appropriate adjustment to reflect any stock
split, combination, reclassification or reorganization of the Series B Preferred Stock). The “Dividend Record Date” shall mean, for each semi-annual dividend, the March 15 or September 15, as the case may be, immediately
preceding the dividend payment date. 
 (b) In addition to the foregoing, subject to the rights of the holders of any shares of any series or
class of capital stock ranking prior, and superior to, or pari passu with, the shares of Series B Preferred Stock with respect to dividends, and prior to the rights of the holders of Common Stock, Series A Preferred Stock and any other series or
class of capital stock, the holders of shares of Series B Preferred Stock shall be entitled to receive, as, when and if declared by the Board of Directors, out of assets legally available for that purpose, dividends or distributions in cash, stock
or otherwise. 
 (c) The Corporation shall not declare or pay any dividend or distribution on any Junior Stock (as defined below) of the
Corporation unless all dividends required by Section 2(a) have been or contemporaneously are declared and paid, or declared and a sum sufficient for the payment thereof set apart for such payment, on the Series B Preferred Stock 

(d) [Reserved] 
 (e) All dividends
or distributions declared upon the Series B Preferred Stock shall be declared pro rata per share. 
 (f) Any reference to
“distribution” contained in this Section 2 shall not be deemed to include any distribution made in connection with or in lieu of any Liquidation Event (as defined below). 

(g) No interest, or sum of money in lieu of interest, shall be payable in respect of any dividend payment or payments on the Series B Preferred
Stock which may be in arrears (it being understood that this provision does not alter the Corporation’s obligations under Section 2(a)). 

  
 - 3 - 

 (h) So long as any shares of the Series B Preferred Stock are outstanding, no dividends, except
as described in the next succeeding sentence, shall be declared or paid or set apart for payment on any class or series of stock of the Corporation ranking, as to dividends, on a parity with the Series B Preferred Stock, for any period unless all
dividends have been or contemporaneously are declared and paid, or declared and a sum sufficient for the payment thereof set apart for such payment, on the Series B Preferred Stock. When dividends are not paid in full or a sum sufficient for such
payment is not set apart, as aforesaid, upon the shares of the Series B Preferred Stock and any other class or series of stock ranking on a parity as to dividends with the Series B Preferred Stock, all dividends declared upon such other stock shall
be declared pro rata so that the amounts of dividends per share declared on the Series B Preferred Stock and such other stock shall in all cases bear to each other the same ratio that accrued dividends per share on the shares of the Series B
Preferred Stock and on such other stock bear to each other. 
 (i) So long as any shares of the Series B Preferred Stock are outstanding, no
other stock of the Corporation ranking on a parity with the Series B Preferred Stock as to dividends or upon liquidation, dissolution or winding up shall be redeemed, purchased or otherwise acquired for any consideration (or any moneys be paid to or
made available for a sinking fund or otherwise for the purchase or redemption of any shares of any such stock) by the Corporation unless the dividends, if any, accrued on all outstanding shares of the Series B Preferred Stock shall have been paid or
set apart for payment. 
 (j) “Junior Stock” shall mean the Common Stock, Series A Preferred Stock, and any shares of preferred
stock of any series or class of the Corporation, whether presently outstanding or hereafter issued, which are junior to the shares of Series B Preferred Stock with respect to (i) the distribution of assets on any voluntary or involuntary
liquidation, dissolution or winding up of the Corporation, (ii) dividends or (iii) voting. 
 3. Liquidation Preference.
(a) In the event of a (i) liquidation, dissolution or winding up of the Corporation, whether voluntary or involuntary, (ii) a sale or other disposition of all or substantially all of the assets of the Corporation or (iii) any
consolidation, merger, combination, reorganization or other transaction in which the Corporation is not the surviving entity or shares of Common Stock constituting in excess of 50% of the voting power of the Corporation are exchanged for or changed
into stock or securities of another entity, cash and/or any other property (a “Merger Transaction”) (items (i), (ii) and (iii) of this sentence being collectively referred to as a “Liquidation Event”), after payment or
provision for payment of debts and other liabilities of the Corporation, the holders of the Series B Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders,
whether such assets are capital, surplus, or earnings, before any payment or declaration and setting apart for payment of any amount shall be made in respect of any Junior Stock of the Corporation, an amount equal to the Dividend Base Amount at such
time; provided, however, in the case of a Merger Transaction, such payment may be made in cash, property (valued as provided in Subsection 3(b)) and/or securities (valued as provided in Subsection 3(b)) of the entity surviving such Merger
Transaction. In the case of property or in the event that any such securities are subject to an investment letter or other similar restriction on transferability, the value of such property or securities shall be determined by agreement between the
Corporation and the holders of a majority of the Series B Preferred Stock then outstanding. If upon any Liquidation Event, whether voluntary or involuntary, the assets to be distributed to 

  
 - 4 - 

 
the holders of the Series B Preferred Stock shall be insufficient to permit the payment to such shareholders of the full preferential amounts aforesaid, then all of the assets of the Corporation
to be distributed shall be so distributed ratably to the holders of the Series B Preferred Stock on the basis of the number of shares of Series B Preferred Stock held. Notwithstanding item (iii) of the first sentence of this Subsection 3(a),
any consolidation, merger, combination, reorganization or other transaction in which the Corporation is not the surviving entity but the stockholders of the Corporation immediately prior to such transaction own in excess of 50% of the voting power
of the corporation surviving such transaction and own amongst themselves such interest in substantially the same proportions as prior to such transaction, shall not be considered a Liquidation Event provided that the surviving corporation shall make
appropriate provisions to ensure that the terms of this Certificate of Designation survive any such transaction. All shares of Series B Preferred Stock shall rank as to payment upon the occurrence of any Liquidation Event senior to the Common Stock,
the Series A Preferred Stock, and, unless the terms of such series shall provide otherwise, senior to all other series of the Corporation’s preferred stock. 

(b) Any securities or other property to be delivered to the holders of the Series B Preferred Stock pursuant to Subsection 3(a) hereof shall be
valued as follows: 
 (i) Securities not subject to an investment letter or other similar restriction on free marketability:

 (A) If actively traded on a Stock Market, the per share value shall be deemed to be the Market Price of such securities as
of the third day prior to the date of valuation. 
 (B) If not actively traded on a Stock Market, the value shall be the Fair
Market Value of such securities. 
 (ii) For securities for which there is an active public market but which are subject to
an investment letter or other restrictions on free marketability, the value shall be the Fair Market Value thereof, determined by discounting appropriately the per share Market Price thereof. 

(iii) For all other securities, the value shall be the Fair Market Value thereof. 

4. Conversion. 
 (a) Right of
Conversion. The shares of Series B Preferred Stock are convertible, in whole or in part, at the option of the holder thereof and upon notice to the Corporation as set forth in Subsection 4(b), into fully paid and nonassessable shares of Common Stock
and such other securities and property as hereinafter provided. The initial conversion price per share of Common Stock (the “Conversion Price”), shall be $.50, subject to adjustment as provided herein. The rate at which each share of
Series B Preferred Stock is convertible at any time into Common Stock (the “Conversion Rate”) shall be determined by dividing the then existing Conversion Price (determined in accordance with this Section 4, including the last
paragraph hereof) into the Dividend Base Amount. 

  
 - 5 - 

 (b) Conversion Procedures. Any holder of shares of Series B Preferred Stock desiring to convert
such shares into Common Stock shall surrender the certificate or certificates evidencing such shares of Series B Preferred Stock at the office of the transfer agent for the Series B Preferred Stock, which certificate or certificates, if the
Corporation shall so require, shall be duly endorsed to the Corporation or in blank, or accompanied by proper instruments of transfer to the Corporation or in blank, accompanied by irrevocable written notice to the Corporation that the holder elects
so to convert such shares of Series B Preferred Stock and specifying the name or names (with address) in which a certificate or certificates evidencing shares of Common Stock are to be issued. The Corporation need not deem a notice of conversion to
be received unless the holder complies with all the provisions hereof. The Corporation will instruct the transfer agent (which may be the Corporation) to make a notation of the date that a notice of conversion is received, which date of receipt
shall be deemed to be the date of receipt for purposes hereof. 
 The Corporation shall, as soon as practicable after such deposit of
certificates evidencing shares of Series B Preferred Stock accompanied by the written notice and compliance with any other conditions herein contained, deliver at such office of such transfer agent to the person for whose account such shares of
Series B Preferred Stock were so surrendered, or to the nominee or nominees of such person, certificates evidencing the number of full shares of Common Stock to which such person shall be entitled as aforesaid, subject to Section 4(d). Subject
to the following provisions of this paragraph, such conversion shall be deemed to have been made as of the date of such surrender of the shares of Series B Preferred Stock to be converted, and the person or persons entitled to receive the Common
Stock deliverable upon conversion of such Series B Preferred Stock shall be treated for all purposes as the record holder or holders of such Common Stock on such date; provided, however, that the Corporation shall not be required to convert any
shares of Series B Preferred Stock while the stock transfer books of the Corporation are closed for any purpose, but the surrender of Series B Preferred Stock for conversion during any period while such books are so closed shall become effective for
conversion immediately upon the reopening of such books as if the surrender had been made on the date of such reopening, and the conversion shall be at the conversion rate in effect on such date. No adjustments in respect of any dividends on shares
surrendered for conversion or any dividend on the Common Stock issued upon conversion shall be made upon the conversion of any shares of Series B Preferred Stock. 

The Corporation shall at all times, reserve and keep available out of its authorized but unissued shares of Common Stock, solely for the
purpose of effecting the conversion of the shares of Series B Preferred Stock, such number of shares of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares of the Series B Preferred Stock. 

All notices of conversion shall be irrevocable; provided, however, that if the Corporation has sent notice of an event pursuant to Subsection
4(g) hereof, a holder of Series B Preferred Stock may, at its election, provide in its notice of conversion that the conversion of its shares of Series B Preferred Stock shall be contingent upon the occurrence of the record date or effectiveness of
such event (as specified by such holder), provided that such notice of conversion is received by the Corporation prior to such record date or effective date, as the case may be. 

  
 - 6 - 

 (c) Adjustment of Conversion Rate and Conversion Price. 

(i) As used in this Subsection 4(c), the following terms shall have the following meanings: 

“Capital Stock” of any Person means the Common Stock or Preferred Stock of such Person. Unless otherwise stated
herein or the context otherwise requires, “Capital Stock” means Capital Stock of the Corporation; “Common Stock” of any Person other than the Corporation means the common equity (however designated), including, without
limitation, common stock or partnership or membership interests of, or participation or interests in such Person (or equivalents thereof). 

“Common Stock” of the Corporation means the Common Stock, par value $.001 per share, of the Corporation, any
successor class or classes of common equity (however designated) of the Corporation into or for which such Common Stock may hereafter be converted, exchanged or reclassified and any class or classes of common equity (however designated) of the
Corporation which may be distributed or issued with respect to such Common Stock or successor class of classes to holders thereof generally. Unless otherwise stated herein or the context requires otherwise, “Common Stock” means Common
Stock of the Corporation; 
 “Current Market Price” means, when used with respect to any security as of any date,
the last sale price, regular way, or, in case no such sale takes place on such date, the average of the closing bid and asked prices, regular way, of such security in either case as reported for consolidated transactions on the New York Stock
Exchange or, if such security is not listed or admitted to trading on the New York Stock Exchange, as reported for consolidated transactions with respect to securities listed on the principal national securities exchange on which such security is
listed or admitted to trading or, if such security is not listed or admitted to trading on any national securities exchange, as reported on the Nasdaq National Market, or, if such security is not listed or admitted to trading on the Nasdaq National
Market, as reported on the Nasdaq SmallCap Market, or if such security is not listed or admitted to trading on any national securities exchange or the Nasdaq National Market or the Nasdaq SmallCap Market, the average of the high bid and low asked
prices of such security in the over-the-counter market, as reported by the National Association of Securities Dealers, Inc. Automated Quotations System or such other
system then in use or, if such security is not quoted by any such organization, the average of the closing bid and asked prices of such security furnished by an NASD member firm selected by the Corporation. If such security is not quoted by any such
organization and no such NASD member firm is able to provide such prices, the Current Market Price of such security shall be the Fair Market Value thereof; 

“Fair Market Value” means, at any date as to any asset, Property or right (including without limitation, Capital
Stock of any Person, evidence of indebtedness or other securities, but excluding cash), the fair market value of such 

  
 - 7 - 

 
item as determined in good faith by the Board of Directors, whose determination shall be conclusive; provided, however, that such determination is described in an Officers’ Certificate filed
with the transfer agent and that, if there is a Current Market Price for such item on such date, “Fair Market Value” means such Current Market Price (without giving effect to the last sentence of the definition thereof); 

“GAAP” means, as of any date, generally accepted accounting principles in the United States and does not include any
interpretations or regulations that have been proposed but that have not become effective; 
 “Officer” means, with
respect to any Person, the Chairman of the Board, the Chief Executive Officer, the President, the Chief Operating Officer, the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller, the Secretary, any Assistant Secretary or
any Vice President of such Person; 
 “Officers’ Certificate” means a certificate signed on behalf of the
Corporation by two Officers, one of whom must be the Chairman of the Board, the President, the Treasurer or a Vice-President of the Corporation; 

“Person” means any individual, corporation, partnership, association, trust or any other entity or organization,
including a government or political subdivision or any agency or instrumentality thereof; 
 “Preferred Stock” of
any Person means the class or classes of equity, ownership or participation interests (however designated) in such Person, including, without limitation, stock, share, partnership and membership interests, which are preferred as to the payment of
dividends or distributions by, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of, such Person (or equivalent thereof) over interests of any other class of interests of such Person. Unless otherwise
stated herein or the context otherwise requires, “Preferred Stock” means Preferred Stock of the Corporation; 

“Property” of any Person means any and all types of real, personal, tangible, intangible or mixed property owned by
such Person whether or not included on the most recent consolidated balance sheet of such Person in accordance with GAAP; 

“Subsidiary” of a Person on any date means any other Person of whom such Person owns, directly or indirectly through
a Subsidiary or Subsidiaries of such Person, Capital Stock with voting power, acting independently and under ordinary circumstances, entitling such person to elect a majority of the board of directors or other governing body of such other Person.
Unless otherwise stated herein or the context otherwise requires, “Subsidiary” means a Subsidiary of the Corporation. 

(ii) If the Corporation shall (i) pay a dividend or other distribution, in Common Stock, on any class of Capital Stock of
the Corporation, subdivide the outstanding Common Stock into a greater number of shares by any means or (iii) 

  
 - 8 - 

 
combine the outstanding Common Stock into a smaller number of shares by any means including, without limitation, a reverse stock split), then in each such case the Conversion Price in effect
immediately prior thereto shall be adjusted so that the Registered Holder of any shares of Series B Preferred Stock thereafter surrendered for conversion shall be entitled to receive the number of shares of Common Stock that such Registered Holder
would have owned or have been entitled to receive upon the happening of such event had such Series B Preferred Stock been converted immediately prior to the relevant record date or, if there is no such record date, the effective date of such event.
An adjustment made pursuant to this Paragraph 4(c)(ii) shall become effective immediately after the record date for the determination of stockholders entitled to receive such dividend or distribution and shall become effective immediately after the
effective date of such subdivision or combination, as the case may be. 
 (iii) If the Corporation shall (i) issue or
distribute (at a price per share less than the Current Market Price per share of such Capital Stock on the date of such issuance or distribution) Capital Stock generally to holders of Common Stock or to holders of any class or series of Capital
Stock which is convertible into or exchangeable or exercisable for Common Stock (excluding an issuance or distribution of Common Stock described in Paragraph 4(c)(ii)) or (ii) issue or distribute generally to such holders rights, warrants,
options or convertible or exchangeable securities entitling the holder thereof to subscribe for, purchase, convert into or exchange for Capital Stock at a price per share less than the Current Market Price per share of such Capital Stock on the date
of issuance or distribution, then, in each such case, at the earliest of (A) the date the Corporation enters into a firm contract for such issuance or distribution, (B) the record date for the determination of stockholders entitled to
receive any such Capital Stock or any such rights, warrants, options or convertible or exchangeable securities or (C) the date of actual issuance or distribution of any such Capital Stock or any such rights, warrants, options or convertible or
exchangeable securities, the Conversion Price shall be reduced by multiplying the Conversion Price in effect immediately prior to such earliest date by: 

(A) if such Capital Stock is Common Stock, a fraction the numerator of which is the number of shares of Common Stock
outstanding, on such earliest date plus the number of shares of Common Stock which could be purchased at the Current Market Price per share of Common Stock on the date of such issuance or distribution with the aggregate consideration (based on the
Fair Market Value thereof) received or receivable by the Corporation either (A) in connection with such issuance or distribution or (B) upon the conversion, exchange, purchase or subscription of all such rights, warrants, options or
convertible or exchangeable securities (the “Aggregate Consideration”), and the denominator of which is the number of shares of Common Stock outstanding on such earliest date plus the number of shares of Common Stock to be so issued or
distributed or to be issued upon the conversion, exchange, purchase or subscription of all such rights, warrants, options or convertible or exchangeable securities; or 

  
 - 9 - 

 (B) if such Capital Stock is other than Common Stock, a fraction the numerator of
which is the Current Market Price per share of Common Stock on such earliest date minus an amount equal to (A) the difference between (1) the Current Market Price per share of such Capital Stock multiplied by the number of shares of such
Capital Stock to be so issued and (2) the Aggregate Consideration, divided by (B) the number of shares of Common Stock outstanding on such date, and the denominator of which is the Current Market Price per share of Common Stock on such
earliest date. 
 Such adjustment shall be made successively whenever any such Capital Stock, rights, warrants, options or convertible or
exchangeable securities are so issued or distributed. In determining whether any rights, warrants, options or convertible or exchangeable securities entitle the holders thereof to subscribe for, purchase, convert into or exchange for shares of such
Capital Stock at less than such Current Market Price, there shall be taken into account the Fair Market Value of any consideration received or receivable by the Corporation for such rights, warrants, options or convertible or exchangeable
securities. If any right, warrant, option or convertible or exchangeable security, the issuance of which resulted in an adjustment in the Conversion Price pursuant to this Paragraph 4(c)(iii), shall expire and shall not have been exercised, the
Conversion Price shall immediately upon such expiration be recomputed to the Conversion Price which would have been in effect if such right, warrant, option or convertible or exchangeable securities had never been distributed or issued.
Notwithstanding anything contained in this paragraph to the contrary, (i) the issuance of Capital Stock upon the exercise of such rights, warrants or options or the conversion or exchange of such convertible or exchangeable securities will not
cause an adjustment in the Conversion Price if no such adjustment would have been required at the time such right, warrant, option or convertible or exchangeable security was issued or distributed; provided, however, that, if the consideration
payable upon such exercise, conversion or exchange and/or the Capital Stock receivable thereupon are changed after the time of the issuance or distribution of such right, warrant, option or convertible or exchangeable security then such change shall
be deemed to be the expiration thereof without having been exercised and the issuance or distribution of new options, rights, warrants or convertible or exchangeable securities and (ii) the issuance of convertible preferred stock of the
Corporation as a dividend on convertible preferred stock of the Corporation will not cause an adjustment in the Conversion Price if no such adjustment would have been required at the time such underlying convertible preferred stock was issued (or as
a result of any subsequent modification to the terms thereof) and the conversion provisions of such convertible stock so issued as a dividend are the same as in such underlying convertible preferred stock. 

Notwithstanding any contained in this Certificate of Designation to the contrary, options, rights or warrants issued or
distributed by the Corporation, including options, rights or warrants distributed prior to the date of filing of this Certificate of Designation, to holders of Common Stock generally which, until the

  
 - 10 - 

 
occurrence of a specified event or events (a “Trigger Event”), (i) are deemed to be transferred with Common Stock, (ii) are not exercisable and (iii) are also issued on a
pro rata basis with respect to future issuances of Common Stock, shall be deemed not to have been issued or distributed for purposes of this Subsection 4(c) (and no adjustment to the Conversion Price under this Subsection 4(c) will be required)
until the occurrence of the earliest Trigger Event. Upon the occurrence of a Trigger Event, such options, rights or warrants shall continue to be deemed not to have been issued or distributed for purposes of this Subsection 4(c) (and no adjustment
to the Conversion Price under this Subsection 4(c) will be required) if and for so long as each Registered Holder who thereafter converts such Registered Holder’s Series B Preferred Stock shall be entitled to receive upon such conversion, in
addition to the shares of Common Stock issuable upon such conversion, a number of such options, rights or warrants, as the case may be, equal to the number of options, rights or warrants to which a holder of the number of shares of Common Stock
equal to the number of shares of Common Stock issuable upon conversion of such Registered Holder’s Series B Preferred Stock is entitled to receive at the time of such conversion in accordance with the terms and provisions of, and applicable to,
such options, rights or warrants. Upon the expiration of any such options, rights or warrants or at such time, if any, as a Registered Holder is not entitled to receive such options, rights or warrants upon conversion of such Registered
Holder’s Series B Preferred Stock, an adjustment (if any is required) to the Conversion Price shall be made in accordance with this Paragraph 4(c)(iii) with respect to the issuance of all such options, rights and warrants as of the date of
issuance thereof, but subject to the provisions of the preceding paragraph, if any such option, right or warrant, including any such options right or warrants distributed prior to the date of filing of this Certificate of Designation, are subject to
events, upon the occurrence of which such options, rights or warrants become exercisable to purchase different securities, evidence of indebtedness, cash, Properties or other assets or different amounts thereof, then, subject to the preceding
provision of this paragraph, the date of the occurrence of any and each such event shall be deemed to be the date of distribution and record date with respect to new options, right or warrants with such new purchase rights (and a termination or
expiration of the existing options, rights or warrants without exercise thereof). In addition, in the event of any distribution (or deemed distribution) of options, rights or warrants, or any Trigger Event or other event of the type described in the
preceding sentence, that required (or would have required but for the provisions of Paragraph 4(c)(vi) or this paragraph) an adjustment to the Conversion Price under this Subsection 4(c) and such options, rights or warrants shall thereafter have
been redeemed or repurchased without having been exercised, then the Conversion Price shall be adjusted upon such redemption or repurchase to give effect to such distribution, Trigger Event or other event, as the case may, as though it had instead
been a cash distribution, equal on a per share basis to the result of the aggregate redemption or repurchase price received by holders of such options, rights or warrants divided by the number of shares of Common Stock outstanding as of the date of
such repurchase or redemption, made to holders of Common Stock generally as of the date of such redemption or repurchase. 

  
 - 11 - 

 (iv) If the Corporation shall pay or distribute, as a dividend or otherwise,
generally to holders of Common Stock or any class or series of Capital Stock which is convertible into or exercisable or exchangeable for Common Stock any assets, Properties or rights (including, without limitation, evidences of indebtedness of the
Corporation, any Subsidiary or any other Person, cash or Capital Stock or other securities of the Corporation, any Subsidiary or any other Person, but excluding payments and distributions as described in Paragraphs 4(c)(ii) or (iii), dividends and
distributions in connection with a Liquidation Event and distributions consisting solely of cash described in Paragraph 4(c)(v)), then in each such case the Conversion Price shall be reduced by multiplying the Conversion Price in effect immediately
prior to the date of such payment or distribution by a fraction, the numerator of which is the Current Market Price per share of Common Stock on the record date for the determination of stockholders entitled to receive such payment or distribution
less the Fair Market Value per share of Common Stock on such record date of the assets, Properties or rights so paid or distributed, and the denominator of which is the Current Market Price per share of Common Stock on such record date. Such
adjustment shall become effective immediately after such record date. For purposes of this Paragraph 4(c)(iv), such Fair Market Value per share shall equal the aggregate Fair Market Value on such record date of the assets, Properties or rights so
paid or distributed divided by the number of shares of Common Stock outstanding on such record date. For all purposes of this Certificate of Designation, adjustments to any security’s conversion or exercise price pursuant to such
security’s original terms shall not be deemed a distribution or dividend to holders thereof. 
 (v) If the Corporation
shall, by dividend or otherwise, make a distribution (other than in connection with the liquidation, dissolution or winding up of the Corporation in its entirety), generally to holders of Common Stock or any class or series of Capital Stock which is
convertible into or exercisable or exchangeable for Common Stock, consisting solely of cash where (x) the sum of (i) the aggregate amount for such cash plus (ii) the aggregate amount of all cash so distributed (by dividend or
otherwise) to such holders within the 12-month period ending on the record date for determining stockholder entitled to receive such distribution with respect to which no adjustment has been made to the
Conversion Price pursuant to this Paragraph 4(c)(v) exceeds (y) 10% of the result of the multiplication of (1) the Current Market Price per share of Common Stock on such record date times (2) the number of shares of Common Stock
outstanding on such record date, then the Conversion Price shall be reduced, effective immediately prior to the opening of business on the day following such record date, by multiplying the Conversion Price in effect immediately prior to the close
of business on the day prior to such record date by a fraction, the numerator of which is the Current Market Price per share of Common Stock on such record date less the aggregate amount of cash per share so distributed and the denominator of which
is such Current Market Price; provided, however, that, if 

  
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the aggregate amount of cash per share is equal to or greater than such Current Market Price, then, in lieu of the foregoing adjustment, adequate provisions shall be made so that each Registered
Holder shall have the right to receive upon conversion (with respect to each share of Common Stock issued upon such conversion and in addition to the Common Stock issuable upon conversion) the aggregate amount of cash per share such Registered
Holder would have received had such Registered Holder’s Series B Preferred Stock been converted immediately prior to such record date. In no event shall the Conversion Price be increased pursuant to this Paragraph 4(c)(v); provided, however,
that if such distribution is not so made, the Conversion Price shall be adjusted to be the Conversion Price which would have been in effect if such distribution had not been declared. For purposes of this Paragraph 4(c)(v), such aggregate amount of
cash per share shall equal such sum divided by the number of shares of Common Stock outstanding on such record date. 
 (vi)
The provisions of this Subsection 4(c) shall similarly apply to all successive events of the type described in this Subsection 4(c). Notwithstanding anything contained herein to the contrary, no adjustment in the Conversion Price shall be required
unless such adjustment would require an increase or decrease of at least 1% in the Conversion Price then in effect; provided, however, that any adjustments which by reason of this Paragraph 4(c)(vi) are not required to be made shall be carried
forward and taken into account in any subsequent adjustment. All calculations under this Section 4 shall be made by the Corporation and shall be made to the nearest cent or to the nearest one hundredth of a share, as the case may be, and the
transfer agent shall be entitled to rely conclusively thereon. Except as provided in this Section 4, no adjustment in the Conversion Price will be made for the issuance of Common Stock or any securities convertible into or exchangeable for
Common Stock or carrying the right to purchase Common Stock or any securities so convertible or exchangeable. 
 (vii)
Whenever the Conversion Price is adjusted as provided herein, the Corporation shall promptly file with the transfer agent an Officers’ Certificate setting forth the Conversion Price in effect after such adjustment and setting forth a brief
statement of the facts requiring such adjustment. Promptly after delivery of such Officers’ Certificate, the Corporation shall give or cause to be given to each Registered Holder a notice of such adjustment of the Conversion Price setting forth
the adjusted Conversion Price and the date on which such adjustment becomes effective. 
 (viii) Notwithstanding anything
contained herein to the contrary, in any case in which this Subsection 4(c) provides that an adjustment in the Conversion Price shall become effective immediately after a record date for an event, the Corporation may defer until the occurrence of
such event (i) issuing to the Registered Holder of any Series B Preferred Stock converted after such record date and before the occurrence of such event the additional shares of Common Stock issuable upon such conversion by reason of the
adjustment required by such event over and above the number of shares of Common Stock issuable upon such conversion before giving effect to such adjustment and (ii) paying to such Registered Holder any amount in cash in lieu of any fractional
share of Common Stock pursuant to Subsection 4(d). 

  
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 (ix) Notwithstanding any other provision hereof, no adjustment to the Conversion
Price shall be made upon the issuance or exercise or conversion of (1) any Capital Stock issued or cash paid as dividends on the Series B Preferred Stock, or (2) any Capital Stock issued or cash paid upon the mandatory conversion or
redemption of any Series B Preferred Stock in accordance with Section 5 of this Certificate of Designation. 
 (d) No Fractional Shares.
No fractional shares or scrip representing fractional shares of Common Stock shall be issued upon conversion of Series B Preferred Stock. If more than one certificate evidencing shares of Series B Preferred Stock shall be surrendered for conversion
at one time by the same holder, the number of full shares issuable upon conversion thereof shall be computed on the basis of the aggregate number of shares of Series B Preferred Stock so surrendered. Instead of any fractional share of Common Stock
which would otherwise be issuable upon conversion of such aggregate number of shares of Series B Preferred Stock, the Corporation may elect, in its sole discretion, independently for each holder, whether such number of shares of Common Stock will be
rounded to the nearest whole share (with a .5 of a share rounded upward) or whether such holder will be given cash, in lieu of any fractional share, in an amount equal to the same fraction of the Market Price of the Common Stock as of the close of
business on the day of conversion. 
 (e) [Reserved] 

(f) Reservation of Shares; Transfer Taxes, Etc. The Corporation shall at all times reserve and keep available, out of its authorized and
unissued shares of Common Stock, solely for the purpose of effecting the conversion of the Series B Preferred Stock, such number of shares of its Common Stock free of preemptive rights as shall be sufficient to effect the conversion of all shares of
Series B Preferred Stock from time to time outstanding. The Corporation shall use its best efforts from time to time, in accordance with the laws of the State of Delaware to increase the authorized number of shares of Common Stock if at any time the
number of shares of authorized, unissued and unreserved Common Stock shall not be sufficient to permit the conversion of all the then-outstanding shares of Series B Preferred Stock. 

The Corporation shall pay any and all issue or other taxes (excluding any income taxes) that may be payable in respect of any issue or delivery
of shares of Common Stock on conversion of the Series B Preferred Stock. The Corporation shall not, however, be required to pay any tax which may be payable in respect of any transfer involved in the issue or delivery of Common Stock (or other
securities or assets) in a name other than that in which the shares of Series B Preferred Stock so converted were registered, and no such issue or delivery shall be made unless and until the person requesting such issue has paid to the Corporation
the amount of such tax or has established, to the satisfaction of the Corporation, that such tax has been paid or need not be paid. 
 (g)
Prior Notice of Certain Events. In case: 

  
 - 14 - 

 (i) the Corporation shall declare any dividend (or any other distribution); or

 (ii) the Corporation shall authorize the granting to the holders of Common Stock or the Series A Preferred Stock of rights
or warrants to subscribe for or purchase any shares of stock of any class or of any other rights or warrants; or 
 (iii) of
any reclassification of Common Stock (other than a subdivision or combination of the outstanding Common Stock, or a change in par value, or from par value to no par value, or from no par value to par value); or 

(iv) of any consolidation or merger to which the Corporation is a party and for which approval of any stockholders of the
Corporation shall be required, or of the sale or transfer of all or substantially all of the assets of the Corporation or of any compulsory share exchange whereby the Common Stock is converted into other securities, cash or other property; or 

(v) of any Liquidation Event; 

then the Corporation shall cause to be filed with the transfer agent for the Series B Preferred Stock, and shall cause to be mailed to the Registered Holders,
at their last addresses as they shall appear upon the stock transfer books of the Corporation, at least twenty (20) days prior to the applicable record date hereinafter specified, a notice stating (x) the date on which a record (if any) is
to be taken for the purpose of such dividend, distribution or granting of rights or warrants or, if a record is not to be taken, the date as of which the holders of Common Stock or Series A Preferred Stock of record to be entitled to such dividend,
distribution, rights or warrants are to be determined and a description of the cash, securities or other property to be received by such holders upon such dividend, distribution or granting of rights or warrants or (y) the date on which such
reclassification, consolidation, merger, sale, transfer, share exchange or Liquidation Event is expected to become effective, the date as of which it is expected that holders of Common Stock of record shall be entitled to exchange their shares of
Common Stock for securities or other property deliverable upon such exchange or Liquidation Event and the consideration, including securities or other property, to be received by such holders upon such exchange; provided, however, that no failure to
mail such notice or any defect therein or in the mailing thereof shall affect the validity of the corporate action required to be specified in such notice. 

(h) Other Changes in Conversion Rate. The Corporation from time to time may increase the Conversion Rate by any amount for any period of time
if the period is at least 20 days and if the increase is irrevocable during the period. Whenever the Conversion Rate is so increased, the Corporation shall mail to the Registered Holders a notice of the increase at least 15 days before the date the
increased Conversion Rate takes effect, and such notice shall state the increased Conversion Rate and the period it will be in effect. 
 The
Corporation may make such increases in the Conversion Rate, in addition to those required or allowed by this Section 4, as shall be determined by it, as evidenced by a resolution of the Board of Directors, to be advisable in order to avoid or
diminish any income tax to holders of Common Stock resulting from any dividend or distribution of stock or issuance of rights or warrants to purchase or subscribe for stock or from any event treated as such for income tax purposes. 

  
 - 15 - 

 Notwithstanding anything to the contrary herein, in no case shall the Conversion Price be
adjusted to an amount less than $.001 per share, the current par value of the Common Stock into which the Series B Preferred Stock is convertible. 

(i) Ambiguities/Errors. The Board of Directors of the Corporation shall have the power to resolve any ambiguity or correct any error in the
provisions relating to the convertibility of the Series B Preferred Stock, and its actions in so doing shall be final and conclusive. 
 5.
Mandatory Conversion and Redemption. (a) In the event the Corporation causes the Series A Preferred Stock to be converted in whole or in part, into fully paid and nonassessable shares of Common Stock, then the Corporation shall also convert the
Series B Preferred Stock, in whole or in part, on a pro rata basis among holders of the Series B Preferred Stock, into fully paid and nonassessable shares of Common Stock using a conversion price of $.50. Any shares of Series B Preferred Stock so
converted shall be treated as having been surrendered by the holder thereof for conversion pursuant to Section 4 on the date of such mandatory conversion (unless previously converted at the option of the holder). 

(b) If, at any time, the Corporation redeems the Series A Preferred Stock, the Corporation may, at its option, redeem the Series B Preferred
Stock, in whole or in part, on a pro rata basis among holders of the Series B Preferred Stock. 
 (c) No greater than 60 nor fewer than 20
days prior to the date of any such mandatory conversion or redemption, notice by first class mail, postage prepaid, shall be given to the holders of record of the Series B Preferred Stock to be converted or redeemed, addressed to such holders at
their last addresses as shown on the stock transfer books of the Corporation. Each such notice shall specify the date fixed for conversion or redemption, the place or places for surrender of shares of Series B Preferred Stock and the then effective
Conversion Rate pursuant to Section 4. 
 Any notice which is mailed as herein provided shall be conclusively presumed to have been duly
given by the Corporation on the date deposited in the mail, whether or not the holder of the Series B Preferred Stock receives such notice; and failure properly to give such notice by mail, or any defect in such notice, to the holders of the shares
to be converted or redeemed shall not affect the validity of the proceedings for the conversion or redemption of any other shares of Series B Preferred Stock. On or after the date fixed for conversion or redemption (the “Take-Out Date”) as stated in such notice, each holder of shares called to be converted or redeemed shall surrender the certificate evidencing such shares to the Corporation at the place designated in such
notice for conversion or redemption. After the mailing of such notice, but before the Take-Out Date as stated therein, all rights whatsoever with respect to the shares so called for conversion or redemption
(except the right of the holders to convert such shares pursuant to Section 4 and to have such shares converted or redeemed, as the case may be, upon surrender of their certificates therefor, pursuant to this Section 5) shall terminate. On
or after the 

  
 - 16 - 

 
Take-Out Date, notwithstanding that the certificates evidencing any shares properly called for conversion or redemption shall not have been surrendered,
such shares shall no longer be deemed outstanding and all rights whatsoever with respect to the shares so called for conversion or redemption (except the right of the holders to have such shares converted or redeemed, as the case may be, upon
surrender of their certificates therefor, pursuant to this Section 5) shall terminate. 
 6. Outstanding Shares. For purposes of this
Certificate of Designation, a share of Series B Preferred Stock, when issued, shall be deemed outstanding except (i) from the date, or the deemed date, of surrender of certificates evidencing shares of Series B Preferred Stock, all shares of
Series B Preferred Stock converted into Common Stock or redeemed pursuant to Section 5 and (ii) from the date of registration of transfer, all shares of Series B Preferred Stock held of record by the Corporation or any subsidiary of the
Corporation. 
 7. Class Voting Rights. The Corporation shall not, without the affirmative vote or consent of the holders of at least 50% of
all outstanding Series B Preferred Stock, voting separately as a class, (i) amend, alter or repeal any provision of the Certificate of Incorporation or the Bylaws of the Corporation so as to adversely affect the relative rights, preferences,
qualifications, limitations or restrictions of the Series B Preferred Stock; (ii) authorize or issue, or increase the authorized amount of, Series B Preferred Stock, other than Series B Preferred Stock issuable in exchange for 8% Notes or
accrued interest thereon or issuable as dividends on Series B Preferred Stock; or (iii) issue securities ranking prior to, or pari passu with the Series B Preferred Stock. 

8. Status of Acquired Shares. Shares of Series B Preferred Stock received upon conversion or redemption pursuant to Section 4 or
Section 5 or otherwise acquired by the Corporation will be restored to the status of authorized but unissued shares of Preferred Stock, without designation as to class, and may thereafter be issued, but not as shares of Series B Preferred
Stock. 
 9. Preemptive Rights. The Series B Preferred Stock is not entitled to any preemptive or subscription rights in respect of any
securities of the Corporation. 
 10. Severability of Provisions. Whenever possible, each provision hereof shall be interpreted in a manner
as to be effective and valid under applicable law, but if any provision hereof is held to be prohibited by or invalid under applicable law, such provision shall be ineffective only to the extent of such prohibition or invalidity, without
invalidating or otherwise adversely affecting the remaining provisions hereof. If a court of competent jurisdiction should determine that a provision hereof would be valid or enforceable if a period of time were extended or shortened or a particular
percentage were increased or decreased, then such court may make such changes as shall be necessary to render the provision in question effective and valid under applicable law. 

  
 - 17 - 

 IN WITNESS WHEREOF, Sudhir Agrawal, President and Acting Chief Executive Officer of the
Corporation, acting for and on behalf of the Corporation, has hereunto subscribed his name this 15 day of March, 2001. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Sudhir Agrawal
		 	Name: Sudhir Agrawal
		 	 Title: President and Acting
 Chief Executive
Officer

  
 - 18 - 

 HYBRIDON, INC. 

CERTIFICATE OF ELIMINATION 
 OF
NUMBER OF SHARES OF PREFERRED STOCK 
 DESIGNATED AS 

SERIES B CONVERTIBLE PREFERRED STOCK 

Hybridon, Inc., a Delaware corporation (the “Corporation”), pursuant to authority conferred upon the Board of Directors of the
Corporation by the Corporation’s Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”), and in accordance with the provisions of Section 151(g) of the General Corporation Law of the State of
Delaware (the “Delaware Law”), certifies that the Board of Directors of the Corporation duly adopted the following resolution: 
  

	“RESOLVED:	That no shares of the Corporation’s Series B Convertible Preferred Stock (the “Series B Preferred Stock”) are outstanding and no shares of Series B Preferred Stock will be issued subject to the
Certificate of Designation dated March 28, 2001 with respect to such series (the “Series B Certificate of Designation”); and that the proper officers of the Corporation be and hereby are authorized and directed in the name and on
behalf of the Corporation to execute and file a certificate with the Secretary of State of the State of Delaware pursuant to Section 151(g) of the Delaware Law setting forth the text of this resolution, upon the filing and effectiveness of
which all matters are set forth in the Series B Certificate of Designation shall be deemed to have been eliminated from the Certificate of Incorporation and the 85,000 shares of Preferred Stock previously designated as Series B Preferred Stock shall
resume their status as undesignated shares of Preferred Stock available for future issuance in accordance with the Certificate of Incorporation.” 

IN WITNESS WHEREOF, the Corporation has caused its corporate seal to be affixed hereto and this Certificate to be signed by its Chief Executive Officer this
10th day of December, 2001. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Stephen R. Seiler
		 	Stephen R. Seiler
		 	Chief Executive Officer

 CERTIFICATE OF DESIGNATIONS 

OF 
 SERIES C JUNIOR PARTICIPATING
PREFERRED STOCK 
 OF 
 HYBRIDON,
INC. 
  
  

Hybridon, Inc., a corporation organized and existing under the laws of the State of Delaware (hereinafter called the “Corporation”), hereby
certifies that the following resolution was adopted by the Board of Directors of the Corporation at a meeting duly called and held on December 10, 2001: 

RESOLVED: That pursuant to the authority granted to and vested in the Board of Directors of the Corporation (hereinafter called the “Board”) in
accordance with the provisions of the Certificate of Incorporation, as amended, the Board hereby creates a series of Preferred Stock, $.01 par value per share (the “Preferred Stock”), of the Corporation and hereby states the designation
and number of shares, and fixes the relative rights, preferences and limitations thereof as follows: 
 Series C Junior Participating
Preferred Stock: 
 Section 1. Designation and Amount. The shares of such series shall be designated as “Series C Junior
Participating Preferred Stock” (the “Series C Preferred Stock”) and the number of shares constituting the Series C Preferred Stock shall be one hundred thousand (100,000). Such number of shares may be increased or decreased by
resolution of the Board prior to issuance; provided, that no decrease shall reduce the number of shares of Series C Preferred Stock to a number less than the number of shares then outstanding plus the number of shares reserved for issuance upon the
exercise of outstanding options, rights or warrants or upon the conversion of any outstanding securities issued by the Corporation convertible into Series C Preferred Stock. 

Section 2. Dividends and Distributions. 

(A) Subject to the rights of the holders of any shares of any series of Preferred Stock (or any similar stock) ranking prior and superior to
the Series C Preferred Stock with respect to dividends, the holders of shares of Series C Preferred Stock, in preference to the holders of Common Stock, par value $.001 per share (the “Common Stock”), of the Corporation, and of any other
junior stock, shall be entitled to receive, when, as and if declared by the Board out of funds of the Corporation legally available for the payment of dividends, quarterly dividends payable in cash on the last day of each fiscal quarter of the
Corporation in each year (each such date being referred to herein as a “Quarterly Dividend Payment Date”), commencing on the first Quarterly 

 
Dividend Payment Date after the first issuance of a share or fraction of a share of Series C Preferred Stock, in an amount per share (rounded to the nearest cent) equal to the greater of
(a) $10 or (b) subject to the provision for adjustment hereinafter set forth, 1,000 times the aggregate per share amount of all cash dividends, and 1,000 times the aggregate per share amount (payable in kind) of all non-cash dividends or other distributions, other than a dividend payable in shares of Common Stock or a subdivision of the outstanding shares of Common Stock (by reclassification or otherwise), declared on the
Common Stock since the immediately preceding Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend Payment Date, since the first issuance of any share or fraction of a share of Series C Preferred Stock. In the event the
Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than
by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the amount to which holders of shares of Series C Preferred Stock were entitled immediately prior to such event
under clause (b) of the preceding sentence shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the
number of shares of Common Stock that were outstanding immediately prior to such event. In the event the Corporation shall at any time declare or pay any dividend on the Series C Preferred Stock payable in shares of Series C Preferred Stock, or
effect a subdivision, combination or consolidation of the outstanding shares of Series C Preferred Stock (by reclassification or otherwise than by payment of a dividend in shares of Series C Preferred Stock) into a greater or lesser number of shares
of Series C Preferred Stock, then in each such case the amount to which holders of shares of Series C Preferred Stock were entitled immediately prior to such event under clause (b) of the first sentence of this Section 2(A) shall be
adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Series C Preferred Stock that were outstanding immediately prior to such event and the denominator of which is the number of shares of Series C
Preferred Stock outstanding immediately after such event. 
 (B) The Corporation shall declare a dividend or distribution on the Series C
Preferred Stock as provided in paragraph (A) of this Section immediately after it declares a dividend or distribution on the Common Stock (other than a dividend payable in shares of Common Stock) and the Corporation shall pay such dividend or
distribution on the Series C Preferred Stock before the dividend or distribution declared on the Common Stock is paid or set apart; provided that, in the event no dividend or distribution shall have been declared on the Common Stock during the
period between any Quarterly Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a dividend of $10 per share on the Series C Preferred Stock shall nevertheless be payable on such subsequent Quarterly Dividend Payment Date.

 (C) Dividends shall begin to accrue and be cumulative on outstanding shares of Series C Preferred Stock from the Quarterly Dividend
Payment Date next preceding the date of issue of such shares, unless the date of issue of such shares is prior to the record date for the first Quarterly Dividend Payment Date, in which case dividends on such shares shall begin to accrue from the
date of issue of such shares, or unless the date of issue is a Quarterly Dividend Payment Date or is a date after the record date for the determination of holders of shares of Series C Preferred Stock entitled to receive a quarterly dividend and
before such Quarterly Dividend 

  
 - 2 - 

 
Payment Date, in either of which events such dividends shall begin to accrue and be cumulative from such Quarterly Dividend Payment Date. Accrued but unpaid dividends shall not bear interest.
Dividends paid on the shares of Series C Preferred Stock in an amount less than the total amount of such dividends at the time accrued and payable on such shares shall be allocated pro rata on a share-by-share basis among all such shares at the time outstanding. The Board may fix a record date for the determination of holders of shares of Series C Preferred Stock entitled to receive payment of a
dividend or distribution declared thereon, which record date shall be not more than 60 days prior to the date fixed for the payment thereof. 

Section 3. Voting Rights. The holders of shares of Series C Preferred Stock shall have the following voting rights: 

(A) Subject to the provision for adjustment hereinafter set forth, each share of Series C Preferred Stock shall entitle the holder thereof to
1,000 votes on all matters submitted to a vote of the stockholders of the Corporation. In the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision,
combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the
number of votes per share to which holders of shares of Series C Preferred Stock were entitled immediately prior to such event shall be adjusted by multiplying such number by a fraction, the numerator of which is the number of shares of Common Stock
outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event. In the event the Corporation shall at any time declare or pay any dividend on the
Series C Preferred Stock payable in shares of Series C Preferred Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Series C Preferred Stock (by reclassification or otherwise than by payment of a dividend in
shares of Series C Preferred Stock) into a greater or lesser number of shares of Series C Preferred Stock, then in each such case the number of votes per share to which holders of shares of Series C Preferred Stock were entitled immediately prior to
such event shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Series C Preferred Stock that were outstanding immediately prior to such event and the denominator of which is the number of
shares of Series C Preferred Stock outstanding immediately after such event. 
 (B) Except as otherwise provided herein, in the Certificate
of Incorporation or by law, the holders of shares of Series C Preferred Stock and the holders of shares of Common Stock and any other capital stock of the Corporation having general voting rights shall vote together as one class on all matters
submitted to a vote of stockholders of the Corporation. 
 (C) (i) If at any time dividends on any Series C Preferred Stock shall be in
arrears in an amount equal to six quarterly dividends thereon, the holders of the Series C Preferred Stock, voting as a separate series from all other series of Preferred Stock and classes of capital stock, shall be entitled to elect two members of
the Board in addition to any Directors elected by any other series, class or classes of securities and the authorized number of Directors will automatically be increased by two. Promptly thereafter, the Board of the Corporation shall, as soon as may
be practicable, call a special meeting of holders of Series C Preferred Stock for the purpose of electing such members of the Board. Such special meeting shall in any event be held within 45 days of the occurrence of such arrearage. 

  
 - 3 - 

 (ii) During any period when the holders of Series C Preferred Stock, voting as a separate series,
shall be entitled and shall have exercised their right to elect two Directors, then, and during such time as such right continues, (a) the then authorized number of Directors shall be increased by two, and the holders of Series C Preferred
Stock, voting as a separate series, shall be entitled to elect the additional Directors so provided for, and (b) each such additional Director shall not be a member of any existing class of the Board, but shall serve until the next annual
meeting of stockholders for the election of Directors, or until his successor shall be elected and shall qualify, or until his right to hold such office terminates pursuant to the provisions of this Section 3(C). 

(iii) A Director elected pursuant to the terms hereof may be removed with or without cause by the holders of Series C Preferred Stock entitled
to vote in an election of such Director. 
 (iv) If, during any interval between annual meetings of stockholders for the election of
Directors and while the holders of Series C Preferred Stock shall be entitled to elect two Directors, there is no such Director in office by reason of resignation, death or removal, then, promptly thereafter, the Board shall call a special meeting
of the holders of Series C Preferred Stock for the purpose of filling such vacancy and such vacancy shall be filled at such special meeting. Such special meeting shall in any event be held within 45 days of the occurrence of such vacancy. 

(v) At such time as the arrearage is fully cured, and all dividends accumulated and unpaid on any shares of Series C Preferred Stock
outstanding are paid, and, in addition thereto, at least one regular dividend has been paid subsequent to curing such arrearage, the term of office of any Director elected pursuant to this Section 3(C), or his successor, shall automatically
terminate, and the authorized number of Directors shall automatically decrease by two, the rights of the holders of the shares of the Series C Preferred Stock to vote as provided in this Section 3(C) shall cease, subject to renewal from time to
time upon the same terms and conditions, and the holders of shares of the Series C Preferred Stock shall have only the limited voting rights elsewhere herein set forth. 

(D) Except as set forth herein, or as otherwise provided by law, holders of Series C Preferred Stock shall have no special voting rights and
their consent shall not be required (except to the extent they are entitled to vote with holders of Common Stock as set forth herein) for taking any corporate action. 

Section 4. Certain Restrictions. 

(A) Whenever quarterly dividends or other dividends or distributions payable on the Series C Preferred Stock as provided in Section 2 are
in arrears, thereafter and until all accrued and unpaid dividends and distributions, whether or not declared, on shares of Series C Preferred Stock outstanding shall have been paid in full, the Corporation shall not: 

  
 - 4 - 

 (i) declare or pay dividends, or make any other distributions, on any shares of
stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series C Preferred Stock; 

(ii) declare or pay dividends, or make any other distributions, on any shares of stock ranking on a parity (either as to
dividends or upon liquidation, dissolution or winding up) with the Series C Preferred Stock, except dividends paid ratably on the Series C Preferred Stock and all such parity stock on which dividends are payable or in arrears in proportion to the
total amounts to which the holders of all such shares are then entitled; 
 (iii) redeem or purchase or otherwise acquire for
consideration shares of any stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series C Preferred Stock, provided that the Corporation may at any time redeem, purchase or otherwise acquire shares of
any such junior stock in exchange for shares of any stock of the Corporation ranking junior (either as to dividends or upon dissolution, liquidation or winding up) to the Series C Preferred Stock; or 

(iv) redeem or purchase or otherwise acquire for consideration any shares of Series C Preferred Stock, or any shares of stock
ranking on a parity with the Series C Preferred Stock, except in accordance with a purchase offer made in writing or by publication (as determined by the Board) to all holders of such shares upon such terms as the Board, after consideration of the
respective annual dividend rates and other relative rights and preferences of the respective series and classes, shall determine in good faith will result in fair and equitable treatment among the respective series or classes. 

(B) The Corporation shall not permit any subsidiary of the Corporation to purchase or otherwise acquire for consideration any shares of stock
of the Corporation unless the Corporation could, under paragraph (A) of this Section 4, purchase or otherwise acquire such shares at such time and in such manner. 

Section 5. Reacquired Shares. Any shares of Series C Preferred Stock purchased or otherwise acquired by the Corporation in any manner
whatsoever shall be retired and cancelled promptly after the acquisition thereof. All such shares shall upon their cancellation become authorized but unissued shares of Preferred Stock and may be reissued as part of a new series of Preferred Stock
subject to the conditions and restrictions on issuance set forth herein, in the Certificate of Incorporation, or in any other Certificate of Designations creating a series of Preferred Stock or any similar stock or as otherwise required by law. 

Section 6. Liquidation, Dissolution or Winding Up. 

(A) Upon any liquidation, dissolution or winding up of the Corporation, no distribution shall be made (1) to the holders of shares of
stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series C Preferred Stock unless, prior thereto, the holders of shares of Series C Preferred Stock shall have received $1,000 per share, plus an

  
 - 5 - 

 
amount equal to accrued and unpaid dividends and distributions thereon, whether or not declared, to the date of such payment, provided that the holders of shares of Series C Preferred Stock shall
be entitled to receive an aggregate amount per share, subject to the provision for adjustment hereinafter set forth, equal to 1,000 times the aggregate amount to be distributed per share to holders of shares of Common Stock, or (2) to the
holders of shares of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series C Preferred Stock, except distributions made ratably on the Series C Preferred Stock and all such parity stock in
proportion to the total amounts to which the holders of all such shares are entitled upon such liquidation, dissolution or winding up. 
 (B)
Neither the consolidation, merger or other business combination of the Corporation with or into any other corporation nor the sale, lease, exchange or conveyance of all or any part of the property, assets or business of the Corporation shall be
deemed to be a liquidation, dissolution or winding up of the Corporation for purposes of this Section 6. 
 (C) In the event the
Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than
by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the aggregate amount to which holders of shares of Series C Preferred Stock were entitled immediately prior to such
event under the proviso in clause (1) of paragraph (A) of this Section 6 shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such
event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event. In the event the Corporation shall at any time declare or pay any dividend on the Series C Preferred Stock payable in
shares of Series C Preferred Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Series C Preferred Stock (by reclassification or otherwise than by payment of a dividend in shares of Series C Preferred Stock)
into a greater or lesser number of shares of Series C Preferred Stock, then in each such case the aggregate amount to which holders of shares of Series C Preferred Stock were entitled immediately prior to such event under the proviso in clause
(1) of paragraph (A) of this Section 6 shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Series C Preferred Stock that were outstanding immediately prior to such event and
the denominator of which is the number of shares of Series C Preferred Stock outstanding immediately after such event. 
 Section 7.
Consolidation, Merger, etc. Notwithstanding anything to the contrary contained herein, in case the Corporation shall enter into any consolidation, merger, combination or other transaction in which the shares of Common Stock are exchanged for
or changed into other stock or securities, cash and/or any other property, then in any such case each share of Series C Preferred Stock shall at the same time be similarly exchanged or changed into an amount per share, subject to the provision for
adjustment hereinafter set forth, equal to 1,000 times the aggregate amount of stock, securities, cash and/or any other property (payable in kind), as the case may be, into which or for which each share of Common Stock is changed or exchanged. In
the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or
otherwise than 

  
 - 6 - 

 
by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the amount set forth in the preceding sentence with respect
to the exchange or change of shares of Series C Preferred Stock shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator
of which is the number of shares of Common Stock that were outstanding immediately prior to such event. In the event the Corporation shall at any time declare or pay any dividend on the Series C Preferred Stock payable in shares of Series C
Preferred Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Series C Preferred Stock (by reclassification or otherwise than by payment of a dividend in shares of Series C Preferred Stock) into a greater or
lesser number of shares of Series C Preferred Stock, then in each such case the amount set forth in the first sentence of this Section 7 with respect to the exchange or change of shares of Series C Preferred Stock shall be adjusted by
multiplying such amount by a fraction, the numerator of which is the number of shares of Series C Preferred Stock that were outstanding immediately prior to such event and the denominator of which is the number of shares of Series C Preferred Stock
outstanding immediately after such event. 
 Section 8. No Redemption. The shares of Series C Preferred Stock shall not be redeemable.

 Section 9. Rank. The Series C Preferred Stock shall rank, with respect to the payment of dividends and the distribution of assets,
junior to all series of any other class of the Preferred Stock issued either before or after the issuance of the Series C Preferred Stock (including, without limitation, the Series A Convertible Preferred Stock $.01 par value, of the Company
established pursuant to the Certificate of Designation for Series A Convertible preferred Stock dated May 5, 1998), unless the terms of any such series shall provide otherwise. 

Section 10. Amendment. At such time as any shares of Series C Preferred Stock are outstanding, the Certificate of Incorporation, as
amended, of the Corporation shall not be amended in any manner which would materially alter or change the powers, preferences or special rights of the Series C Preferred Stock so as to affect them adversely without the affirmative vote of the
holders of at least two-thirds of the outstanding shares of Series C Preferred Stock, voting together as a single class. 

Section 11. Fractional Shares. Series C Preferred Stock may be issued in fractions of a share which shall entitle the holder, in
proportion to such holder’s fractional shares, to exercise voting rights, receive dividends, participate in distributions and have the benefit of all other rights of holders of Series C Preferred Stock. 

  
 - 7 - 

 IN WITNESS WHEREOF, this Certificate of Designations is executed on behalf of the Corporation by
its Chief Executive Officer this 10th day of December, 2001. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Stephen R. Seiler
		 	Name: Stephen R. Seiler
		 	Title: Chief Executive Officer

  
 - 8 - 

 CERTIFICATE OF CORRECTION 

OF 
 CERTIFICATE OF
DESIGNATION FOR 
 SERIES A CONVERTIBLE PREFERRED STOCK 

OF 
 HYBRIDON, INC.

 Hybridon, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware,
DOES HEREBY CERTIFY: 
 1. The name of the corporation is Hybridon, Inc. 

2. A Certificate of Designation for Series A Convertible Preferred Stock of Hybridon, Inc. (the “Certificate of Designation”) was
filed with the Secretary of State of the State of Delaware on May 6, 1998, and the Certificate of Designation requires correction was permitted by Section 103(f) of the General Corporation Law of the State of Delaware. 

3. The Certificate of Designation was an inaccurate record of the corporate action taken in the Section 7 thereof incorrectly provided as
follows: 
 “7. Class Voting Rights. The Corporation shall not, without the affirmative vote or consent of the holders of at least 50%
of all outstanding Series A Preferred Stock, voting separately as a class, (i) amend, alter or repeal any provisions of the Certificate of Incorporation or the Bylaws of the Corporation so as adversely to affect the relative rights,
preferences, qualifications, limitations or restrictions of the Series A Preferred Stock (it being understood that the issuance of securities ranking prior to, or pari passu with, the Series A Preferred Stock (A) upon a Liquidation Event or
(B) with respect to the payment of dividends or distributions shall not be considered adversely to affect such relative rights, preferences, qualifications, limitations or restrictions); or (ii) authorize or issue, or increase the
authorized amount of, Series A Preferred Stock, other than Series A Preferred Stock issuable in connection with the Offering, issuable in exchange for 9% Notes or accrued interest thereon or issuable as dividends on Series A Preferred Stock.”

 4. As corrected hereby, Section 7 of the Certificate of Designation shall provide as follows: 

“7. Voting Rights. Except as provided herein or required by law or by the Certificate of Incorporation of the Corporation, the holders of
shares of Series A Preferred Stock shall not be entitled to vote on any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation (or by written action of stockholders
in lieu of a meeting). The Corporation shall not, without the affirmative vote or consent of the holders of at least 50% of all outstanding Series A Preferred Stock, voting separately as a class, (i) amend, alter or repeal any provision of the
Certificate of Incorporation or the Bylaws of the Corporation so as adversely to affect the relative rights, preferences, qualifications, limitations or restrictions of the Series A Preferred Stock (it being understood that the issuance of
securities ranking prior to, or pari passu with, the Series A Preferred Stock (A) upon a Liquidation Event or (B) with respect to the payment of dividends of distributions shall 

 
not be considered adversely to affect such relative rights, preferences, qualifications, limitations or restrictions); or (ii) authorize or issue, or increase the authorized amount of,
Series A Preferred Stock, other than Series A Preferred Stock issuable in connection with the Offering, issuable in exchange for 9% Notes or accrued interest thereon or issuable as dividends on Series A Preferred Stock.” 

IN WITNESS WHEREOF, Hybridon, Inc. has caused this Certificate of Designation to be signed by its Chief Financial Officer this 13th day of May 2002. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Robert Andersen
		 	Robert G. Andersen
		 	Chief Financial Officer

  
 - 2 - 

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED
CERTIFICATE OF INCORPORATION 
 OF 

HYBRIDON, INC. 
 Hybridon,
Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General Corporation Law of the State of Delaware, does hereby certify as follows: 

At a meeting of the Board of Directors of the Corporation a resolution was duly adopted, pursuant to Section 242 of the General
Corporation Law of the State of Delaware, setting forth an amendment to the Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), and declaring said amendment to be advisable.
The stockholders of the Corporation duly approved said proposed amendment in accordance with Section 242 of the General Corporation Law of the State of Delaware at a meeting of stockholders held on June 19, 2002. The resolution setting
forth the amendment is as follows: 
  

	RESOLVED:	That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in its entirety so that the same shall read as follows: 

“FOURTH. The total number of shares of all classes of stock which the Corporation shall have authority to issue is (i) One Hundred
Fifty Million (150,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred Stock, $.01 par value per share (“Preferred Stock”), which may
be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 
 IN WITNESS WHEREOF, the
Corporation has caused this Certificate of Amendment to be signed by its Chief Executive Officer on this 10th day of July, 2002. 

 

	
	HYBRIDON, INC.
	
	/s/ Stephen R. Seiler
	Name: Stephen R. Seiler
	Title: Chief Executive Officer

  

 CERTIFICATE OF AMENDMENT 

OF 
 RESTATED CERTIFICATE
OF INCORPORATION 
 OF 

HYBRIDON, INC. 
 Hybridon,
Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General Corporation Law of the State of Delaware, does hereby certify as follows: 

By action of the Board of Directors of the Corporation at a meeting a resolution was duly adopted, pursuant to Section 242 of the General
Corporation Law of the State of Delaware, setting forth amendments to the Certificate of Incorporation of the Corporation and declaring said amendments to be advisable. The stockholders of the Corporation duly approved said proposed amendments at a
meeting in accordance with Section 242 of the General Corporation Law of the State of Delaware. The resolutions setting forth the amendments are as follows: 
  

	RESOLVED:	That Section 2(a) of the Certificate of Designation of the Series A Convertible Preferred Stock of the Corporation filed on May 6, 1998 is hereby amended by deleting the reference to “6.5%” therein
and inserting in lieu thereof “1.0%”. 

  

	RESOLVED:	That Section 3(a) of the Certificate of Designation of the Series A Convertible Preferred Stock of the Corporation filed on May 6, 1998 is hereby amended by deleting the first sentence of Section 3(a) in
its entirety and inserting in lieu thereof the following sentence: 

 “3. Liquidation Preference. (a) In the
event of a (i) liquidation, dissolution or winding up of the Corporation, whether voluntary or involuntary, (ii) a sale or other disposition of all or substantially all of the assets of the Corporation or (iii) any consolidation,
merger, combination, reorganization or other transaction in which the Corporation is not the surviving entity or shares of Common Stock constituting in excess of 50% of the voting power of the Corporation are exchanged for or changed into stock or
securities of another entity, cash and/or any other property (a “Merger Transaction”) (items (i), (ii) and (iii) of this sentence being collectively referred to as a “Liquidation Event”), after payment or provision for
payment of debts and other liabilities of the Corporation, the holders of the Series A Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders, whether such
assets are capital, surplus, or earnings, before any payment or declaration and setting apart for payment of any amount shall be made in respect of any Junior Stock of the Corporation, an amount equal to $1.00 per share (subject to appropriate
adjustment in the event of any stock split, stock dividend, combination or other similar recapitalization affecting the Series A Preferred Stock), plus any dividends declared or accrued but unpaid on such shares; provided, however, in the case of a
Merger Transaction, such payment may be made in cash, property (valued as provided in Subsection 3(b)) and/or securities (valued as provided in Subsection 3(b)) of the entity surviving such Merger Transaction.” 

 

	RESOLVED:	That Section 4(a) of the Certificate of Designation of the Series A Convertible Preferred Stock of the Corporation filed on May 6, 1998 is hereby amended by deleting the first paragraph of Section 4(a) in
its entirety and inserting in lieu thereof the following paragraph: 

  

 “(a) Right of Conversion. Commencing after the expiration of 12 months following the
Alternative Equity Closing Date (as hereinafter defined), but not prior thereto, the shares of Series A Preferred Stock shall be convertible, in whole or in part, at the option of the holder thereof and upon notice to the Corporation as set forth in
Subsection 4(b), into fully paid and nonassessable shares of Common Stock and such other securities and property as hereinafter provided. The initial conversion price per share of Common Stock (the “Conversion Price”), shall be equal to
the product of 2.125 multiplied by the per share price (the “Stated Common Price”) of Common Stock sold by the Corporation in connection with the Alternative Equity Offering (as such term is defined in the Corporation’s Offer to
Exchange dated February 6, 1998 (the “Original Offer to Exchange”), as amended by the Amendment thereto (the “Amendment”) dated March 30, 1998 (collectively, the “Offer to Exchange”)) and shall be subject to
adjustment as provided herein. The rate at which each share of Series A Preferred Stock is convertible at any time into Common Stock (the “Conversion Rate”) shall be determined by dividing the then existing Conversion Price (determined in
accordance with this Section 4, including the last paragraph hereof) into the Dividend Base Amount; provided, however, that, during the period beginning on the date of the filing of this Certificate of Amendment and ending on the date 60 days
after the date of the filing of this Certificate of Amendment (the “Early Conversion Period”), the Conversion Rate shall be determined by dividing the Conversion Price (in effect as of the first day of the Early Conversion Period) into an
amount equal to 125% of the Dividend Base Amount. For illustrative purposes only, if the Conversion Price equals $4.25 and the Dividend Base Amount equals $100.00, then each share of Series A Preferred Stock will be convertible into 23.53 shares of
Common Stock ($100.00 ÷ $4.25); provided, however, that during the Early Conversion Period, each share of Series A Preferred Stock will be convertible into 29.41 shares of Common Stock ($125.00 ÷ $4.25).” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its authorized officer on the 4th day of December, 2003. 
  

			
	By:	 	/s/ Stephen R. Seiler
	Name:	 	Stephen R. Seiler
	Title:	 	Chief Executive Officer

  
 - 2 - 

 CERTIFICATE OF INCREASE 

OF 
 SERIES C JUNIOR PARTICIPATING
PREFERRED STOCK 
 OF 
 HYBRIDON,
INC. 
 (Pursuant to Section 151(g) of the 

Delaware General Corporation Law) 

Hybridon, Inc., a corporation organized and existing under the Delaware General Corporation Law (the “Corporation”) does hereby
certify: 
  

	FIRST:	In a Certificate of Designations filed with the Secretary of State of the State of Delaware on December 10, 2001, pursuant to Section 151 of the Delaware General Corporation Law, the Corporation was authorized
to issue 100,000 shares of Series C Junior Participating Preferred Stock as a series of the Corporation’s authorized Preferred Stock, par value $.01 per share; and 

 

	SECOND:	The board of directors of the Corporation, by resolution adopted June 22, 2003, duly authorized and directed that the number of shares of the Corporation’s Series C Junior Participating Preferred Stock be
increased from 100,000 shares to 150,000 shares. 

 IN WITNESS WHEREOF, the Corporation has caused this Certificate of
Increase to be signed by its duly authorized officer this 4th day of December, 2003. 
  

			
	By:	 	/s/ Stephen R. Seiler
		 	Name: Stephen R. Seiler
		 	Title: Chief Executive Officer

  

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED CERTIFICATE OF
INCORPORATION 
 OF 
 HYBRIDON,
INC. 
 Hybridon, Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General
Corporation Law of the State of Delaware, does hereby certify as follows: 
 At a meeting of the Board of Directors of the Corporation a
resolution was duly adopted, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate
of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in accordance with Section 242 of the General Corporation Law of the State of Delaware at a meeting
of stockholders held on June 24, 2004. The resolution setting forth the amendment is as follows: 
  

	RESOLVED:	That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in its entirety so that the same shall read as follows: 

“FOURTH. The total number of shares of all classes of stock which the Corporation shall have authority to issue is
(i) One Hundred Eighty Five Million (185,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred Stock, $.01 par value per share
(“Preferred Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its Chief Executive Officer on this 25th day of
June 2004. 
  

	
	HYBRIDON, INC.
	
	/s/ Stephen R. Seiler
	Name: Stephen R. Seiler
	Title: Chief Executive Officer

 CERTIFICATE OF INCREASE 

OF 
 SERIES C JUNIOR PARTICIPATING
PREFERRED STOCK 
 OF 
 HYBRIDON,
INC. 
 (Pursuant to Section 151(g) of the 

Delaware General Corporation Law) 

Hybridon, Inc., a corporation organized and existing under the Delaware General Corporation Law (the “Corporation”) does hereby
certify: 
  

	FIRST:	In a Certificate of Designations filed with the Secretary of State of the State of Delaware on December 10, 2001, pursuant to Section 151 of the Delaware General Corporation Law, the Corporation was authorized
to issue 100,000 shares of Series C Junior Participating Preferred Stock as a series of the Corporation’s authorized Preferred Stock, par value $.01 per share; 

 

	SECOND:	In a Certificate of Increase filed with the Secretary of State of the State of Delaware on December 4, 2003, pursuant to Section 151 of the Delaware General Corporation Law, the number of authorized shares of
the Corporation’s Series C Junior Participating Preferred Stock was increased from 100,000 to 150,000; and 

  

	THIRD:	The board of directors of the Corporation, by resolution adopted March 15, 2005, duly authorized and directed that the number of authorized shares of the Corporation’s Series C Junior Participating Preferred
Stock be increased from 150,000 shares to 185,000 shares. 

 IN WITNESS WHEREOF, the Corporation has caused this Certificate
of Increase to be signed by its duly authorized officer this 24th day of March, 2005. 
  

			
	By:	 	/s/ Sudhir Agrawal
		 	Name: Sudhir Agrawal, D. Phil
		 	Title: Chief Executive Officer, President and Chief Scientific Officer

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED CERTIFICATE OF
INCORPORATION 
 OF 
 HYBRIDON,
INC. 
 Hybridon, Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General
Corporation Law of the State of Delaware, does hereby certify as follows: 
 At a meeting of the Board of Directors of the Corporation a
resolution was duly adopted, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate
of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in accordance with Section 242 of the General Corporation Law of the State of Delaware at a meeting
of stockholders held on June 15, 2005. The resolution setting forth the amendment is as follows: 
  

	RESOLVED:	That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in its entirety so that the same shall read as follows: 

“FOURTH. The total number of shares of all classes of stock which the Corporation shall have authority to issue is (i) Two Hundred
Million (200,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred Stock, $.01 par value per share (“Preferred Stock”), which may be
issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 
 IN WITNESS WHEREOF, the Corporation
has caused this Certificate of Amendment to be signed by its Chief Executive Officer on this 17th day of June 2005. 
  

	
	HYBRIDON, INC.
	
	/s/ Sudhir Agrawal
	Name: Sudhir Agrawal
	Title: Chief Executive Officer

 CERTIFICATE OF INCREASE 

OF 
 SERIES C JUNIOR PARTICIPATING
PREFERRED STOCK 
 OF 
 HYBRIDON,
INC. 
 (Pursuant to Section 151(g) of the 

Delaware General Corporation Law) 

Hybridon, Inc., a corporation organized and existing under the Delaware General Corporation Law (the “Corporation”) does hereby
certify: 
  

	FIRST:	In a Certificate of Designations filed with the Secretary of State of the State of Delaware on December 10, 2001, pursuant to Section 151 of the Delaware General Corporation Law, the Corporation was authorized
to issue 100,000 shares of Series C Junior Participating Preferred Stock as a series of the Corporation’s authorized Preferred Stock, par value $.01 per share; 

 

	SECOND:	In a Certificate of Increase filed with the Secretary of State of the State of Delaware on December 4, 2003, pursuant to Section 151 of the Delaware General Corporation Law, the number of authorized shares of
the Corporation’s Series C Junior Participating Preferred Stock was increased from 100,000 to 150,000; 

  

	THIRD:	In a Certificate of Increase filed with the Secretary of State of the State of Delaware on March 24, 2005, pursuant to Section 151 of the Delaware General Corporation Law, the number of authorized shares of
the Corporation’s Series C Junior Participating Preferred Stock was increased from 150,000 to 185,000; and 

  

	FOURTH:	The board of directors of the Corporation, by resolution adopted March 15, 2005, duly authorized and directed that, effective as of June 15, 2005, the number of authorized shares of the Corporation’s
Series C Junior Participating Preferred Stock be increased from 185,000 shares to 200,000 shares. 

 IN WITNESS WHEREOF, the
Corporation has caused this Certificate of Increase to be signed by its duly authorized officer this 21st day of June 2005. 
  

			
	By:	 	/s/ Robert G. Andersen
		 	Name: Robert G. Andersen
		 	Title: Chief Financial Officer

 CERTIFICATE OF OWNERSHIP AND MERGER 

MERGING 
 IDERA PHARMACEUTICALS,
INC. 
 (a Delaware corporation) 

INTO 
 HYBRIDON, INC. 

(a Delaware corporation) 

Pursuant to Section 253 of the General Corporation Law of the State of Delaware, Hybridon, Inc., a corporation organized and existing
under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify: 
 FIRST:
That the Corporation was incorporated on May 25, 1989, pursuant to the General Corporation Law of the State of Delaware. 
 SECOND: That
the Corporation owns all of the outstanding shares of the capital stock of Idera Pharmaceuticals, Inc., a corporation incorporated on August 24, 2005, pursuant to the General Corporation Law of the State of Delaware (the
“Subsidiary”). 
 THIRD: That on September 9, 2005, the Board of Directors of the Corporation, acting by written consent in
accordance with Section 141(f) of the General Corporation Law of the State of Delaware, duly adopted the following resolutions and determined to merge the Subsidiary into the Corporation and change the Corporation’s corporate name to
“Idera Pharmaceuticals, Inc.” on the conditions set forth in such resolutions: 
  

	 	RESOLVED:	That, the Corporation shall, pursuant to Section 253 of the Delaware Code, merge into itself Idera Pharmaceuticals, Inc., a wholly owned subsidiary of the Corporation (the “Subsidiary”), and shall assume
all of the Subsidiary’s liabilities and obligations (the “Merger”); and that upon the effectiveness of the Merger, the Corporation’s corporate name shall be changed to “Idera Pharmaceuticals, Inc.” 

 

	 	RESOLVED:	That the Corporation, as the sole stockholder of the Subsidiary, be and hereby is authorized to take such actions as are necessary or appropriate to effect the Merger. 

 

	 	RESOLVED:	 That the Chief Executive Officer and the Chief Financial Officer of the Corporation (the “Proper Officers”) be, and either acting singly,
hereby is authorized and directed in the name and on behalf of the Corporation to prepare, execute and file with the Secretary of State of the State of Delaware a Certificate of 

	 	
Ownership and Merger setting forth a copy of the resolutions to merge the Subsidiary into the Corporation and to assume the liabilities and obligations of said Subsidiary and to change the
Corporation’s corporate name to “Idera Pharmaceuticals, Inc.” upon the effectiveness of the Merger; and that the execution and filing thereof be conclusive evidence of such approval and the authorization therefor by the Board of
Directors of the Corporation. 

 FOURTH: That the Merger of Subsidiary into the Corporation be effective as of
September 12, 2005 at 4:01 p.m. (ET). 
 IN WITNESS WHEREOF, the Corporation has caused this Certificate to be signed by its authorized
officer this 12th day of September, 2005. 
  

			
	HYBRIDON, INC.
		
	By:	 	/s/ Sudhir Agrawal
		 	Name: Sudhir Agrawal
		 	Title: Chief Executive Officer and President

  
 - 2 - 

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED CERTIFICATE OF
INCORPORATION 
 OF 
 IDERA
PHARMACEUTICALS, INC. 
 Idera Pharmaceuticals, Inc. (hereinafter called the “Corporation”), organized and existing under and by
virtue of the General Corporation Law of the State of Delaware, does hereby certify as follows: 
 By action of the Board of Directors of
the Corporation at a meeting held on April 12, 2006, the Board of Directors of the Corporation duly adopted a resolution, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the
Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in
accordance with Section 242 of the General Corporation Law of the State of Delaware at a meeting of stockholders held on June 7, 2006. The resolution setting forth the amendment is as follows: 

 

	RESOLVED:	That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in its entirety so that the same shall read as follows: 

 

	    	“FOURTH. That, effective at 5:00 p.m., eastern time, on the filing date of this Certificate of Amendment of Restated Certificate of Incorporation, as amended, (the “Effective Time”), a one-for-eight reverse stock split of the Corporation’s Common Stock (as defined below) shall become effective, pursuant to which each eight shares of Common Stock
outstanding and held of record by each stockholder of the Corporation (including treasury shares) immediately prior to the Effective Time shall be reclassified and combined into one share of Common Stock automatically and without any action by the
holder thereof upon the Effective Time and shall represent one share of Common Stock from and after the Effective Time. No fractional shares of Common Stock shall be issued as a result of such reclassification and combination. In lieu of any
fractional shares to which the stockholder would otherwise be entitled, the Corporation shall pay cash equal to such fraction multiplied by the average of the high and low trading prices of the Common Stock on the American Stock Exchange during
regular trading hours for the five trading days immediately preceding the Effective Time. 

 The total number of shares of all classes of stock which the Corporation shall have authority to
issue is (i) Forty Million (40,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred Stock, $.01 par value per share (“Preferred
Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 
 IN WITNESS
WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its duly authorized officer this 29th day of June 2006. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	/s/ Robert G. Andersen
		 	Robert G. Andersen
		 	 Chief Financial Officer,
 Vice President
Operations

  
 - 2 - 

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED CERTIFICATE OF
INCORPORATION 
 OF 
 IDERA
PHARMACEUTICALS, INC. 
 Idera Pharmaceuticals, Inc. (hereinafter called the “Corporation”), organized and existing under and by
virtue of the General Corporation Law of the State of Delaware, does hereby certify as follows: 
 By action of the Board of Directors of
the Corporation at a meeting held on March 18, 2008, the Board of Directors of the Corporation duly adopted a resolution, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the
Restated Certificate of Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in
accordance with Section 242 of the General Corporation Law of the State of Delaware at a meeting of stockholders held on June 4, 2008. The resolution setting forth the amendment is as follows: 

RESOLVED: That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in its entirety
so that the same shall read as follows: 
 “FOURTH. The total number of shares of all classes of stock which the Corporation shall have
authority to issue is (i) Seventy Million (70,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred Stock, $.01 par value per share
(“Preferred Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its duly authorized officer this 2nd day of July
2008. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	/s/ Louis J. Arcudi, III
		 	Name: Louis J. Arcudi, III
		 	Title: Chief Financial Officer

 CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS 

OF 
 SERIES D PREFERRED
STOCK 
 OF 
 IDERA
PHARMACEUTICALS, INC. 
 (Pursuant to Section 151 of 

the Delaware General Corporation Law) 

Idera Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under the laws of the State of
Delaware, hereby certifies that, pursuant to authority conferred on its Board of Directors (the “Board”) by the Restated Certificate of Incorporation of the Corporation, as amended, the following resolution was adopted by the Board
at a meeting duly called and held on November 4, 2011, which resolution remains in full force and effect on the date hereof: 
 RESOLVED, that
there is hereby created and established a series of the Corporation’s authorized Preferred Stock (the “Preferred Stock”) having a par value of $0.01 per share, which series shall be designated as “Series D Convertible
Preferred Stock” (the “Series D Preferred Stock”) and shall consist of 1,124,260 shares. The shares of Series D Preferred Stock shall have the voting powers, designations, preferences and other special rights, and
qualifications, limitations and restrictions thereof set forth below: 
 1. Dividends. 

1.1 Each holder of Series D Preferred Stock shall be entitled to receive, with respect to each share of Series D Preferred Stock then
outstanding and held by such holder of Series D Preferred Stock, dividends, commencing from the date of issuance of such share of Series D Preferred Stock, at the rate of seven percent (7%) per annum (on the basis of a 360 day year) of the
Series D Original Issue Price (as defined below) (the “Series D Preferred Dividends”). The Series D Preferred Dividends shall be cumulative, whether or not earned or declared, shall be paid quarterly in arrears on the last day of
December, March, June and September (a “Quarterly Dividend Payment Date”) in each year that Series D Preferred Stock is outstanding, with the first Quarterly Dividend Payment Date being December 31, 2011, and shall be prorated
for periods shorter than one quarter. The rights of a holder of Series D Preferred Stock as Series D Preferred Dividends shall rank senior to the rights of the Corporation’s Series A Convertible Preferred Stock as to dividends. The Series D
Preferred Dividends shall be paid to each holder of Series D Preferred Stock in cash out of legally available funds or, at the Corporation’s election, through the issuance of such number of shares of the Corporation’s Common Stock, par
value $0.001 per share (the “Common Stock”) (rounded down to the nearest whole share with any fractional shares being issued in cash in an amount equal to the Market Price (as defined in Section 4.2 below) of such fractional
share of Common Stock) determined by dividing the amount of the total accrued but unpaid dividends 

 
then outstanding on such holder’s shares of Series D Preferred Stock by the Market Price then in effect (which for this purpose may not be less than $1.46 per share, subject to appropriate
adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Common Stock); provided, however, that (i) the Corporation may not pay such dividends in shares of
Common Stock on or prior to December 31, 2014, (ii) the Corporation may not issue shares of Common Stock in excess of that number of shares of Common Stock which, upon giving effect to such issuance, would cause (a) the aggregate
number of shares of Common Stock beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of
Section 13(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Corporation following such issuance, or
(b) the combined voting power of the securities of the Corporation beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the
holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined voting power of all of the securities of the Corporation then outstanding following such issuance, unless, in either case, the Corporation obtains
the requisite stockholder approval under NASDAQ Marketplace Rule 5635(b) (the “Issuance Limitation”), in which case, the Issuance Limitation under this clause (ii) shall no longer apply to the payment of dividends hereunder and
(iii) if clause (ii) shall in fact limit the issuance of any shares of Common Stock in payment of a given dividend, then the Corporation’s election to pay such dividend in shares of Common Stock shall be ineffective to the extent of
such limitation and such dividend shall instead thereupon be paid in cash by the Corporation out of legally available funds. Any election by the Corporation to pay Series D Preferred Dividends in cash or shares of Common Stock shall be made
uniformly with respect to all outstanding shares of Series D Preferred Stock for a given dividend period. For purposes of this Section 1.1 the aggregate number of shares of Common Stock or voting securities beneficially owned by a holder of
Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act, shall include the shares of Common Stock
to be issued as part of such dividend payment, but shall exclude the number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or non-cancelled portion of any other securities of the Corporation that do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire at any
time Common Stock, including without limitation any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive,
Common Stock), subject to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be aggregated
with the holder’s for purposes of Section 13(d) of the Exchange Act. 
 1.2 Notwithstanding the foregoing, if any Series D
Preferred Dividend is not paid by the Corporation within five trading days following a Quarterly Dividend Payment Date, such Series D Preferred Dividend shall continue to accrue and the Corporation shall be obligated to pay the holders a late fee
with respect to such Series D Preferred Dividend, which shall be paid by the Corporation in cash, at the rate of sixteen percent (16%) per annum (or such lesser 

  
 - 2 - 

 
rate permitted by applicable law) (the “Dividend Late Fee”), and shall accrue daily from the applicable Quarterly Dividend Payment Date through and including the date the
Corporation pays such Series D Preferred Dividend plus the Dividend Late Fee in full (which amount shall be paid as liquidated damages and not as a penalty); provided however, that no Dividend Late Fee shall accrue or be owed with respect to
any Series D Preferred Dividend (i) that the Corporation is not permitted to pay under Delaware law or (ii) to be paid in cash that is not paid at a time when the Corporation has less than $10 million of cash and cash equivalents as of the
applicable Quarterly Dividend Payment Date as certified in writing by the Corporation to the holders. 
 1.3 The Corporation shall not
declare, pay or set aside any dividends on shares of any other class or series of capital stock of the Corporation (other than dividends on shares of Common Stock payable in shares of Common Stock and dividends on the Series A Convertible Preferred
Stock in accordance with Section 2(a) of the Certificate of Designations for the Series A Convertible Preferred Stock) unless the holders of the Series D Preferred Stock then outstanding shall first receive, or simultaneously receive, a
dividend on each outstanding share of Series D Preferred Stock in an amount at least equal to the sum of (i) the amount of the aggregate dividends then accrued on such share of Series D Preferred Stock and not previously paid and
(ii) (A) in the case of a dividend on Common Stock or any class or series that is convertible into Common Stock, that dividend per share of Series D Preferred Stock as would equal the product of (1) the dividend payable on each share
of such class or series determined, if applicable, as if all shares of such class or series had been converted into Common Stock and (2) the number of shares of Common Stock issuable upon conversion of a share of Series D Preferred Stock, in
each case calculated on the record date for determination of holders entitled to receive such dividend or (B) in the case of a dividend on any class or series that is not convertible into Common Stock, at a rate per share of Series D Preferred
Stock determined by (1) dividing the amount of the dividend payable on each share of such class or series of capital stock by the original issuance price of such class or series of capital stock (subject to appropriate adjustment in the event
of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (2) multiplying such fraction by an amount equal to the Series D Original Issue Price; provided that, if the
Corporation declares, pays or sets aside, on the same date, a dividend on shares of more than one class or series of capital stock of the Corporation, the dividend payable to the holders of Series D Preferred Stock pursuant to this
Section 1.3 shall be calculated based upon the dividend on the class or series of capital stock that would result in the highest Series D Preferred Stock dividend. 

1.4 The “Series D Original Issue Price” shall mean $8.1375 per share, subject to appropriate adjustment in the event of any
stock dividend, stock split, combination or other similar recapitalization with respect to the Series D Preferred Stock. 
 2.
Liquidation, Dissolution or Winding Up. 
 2.1 Payments to Holders of Series D Preferred Stock. In the event of any voluntary
or involuntary liquidation, dissolution or winding up of the Corporation, the holders of shares of Series D Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its
stockholders before any payment shall be made to the holders of Common Stock, Series A Convertible Preferred Stock or any other class of capital stock of the Corporation ranking junior to the Series D Preferred Stock as to liquidation,

  
 - 3 - 

 
by reason of their ownership thereof, an amount per share equal to the greater of (i) the Series D Original Issue Price, plus any dividends accrued or declared but unpaid thereon, or
(ii) such amount per share as would have been payable with respect to such share had all shares of Series D Preferred Stock been converted into Common Stock pursuant to Section 4 immediately prior to such liquidation, dissolution or
winding up. If upon any such liquidation, dissolution or winding up of the Corporation, the assets of the Corporation available for distribution to its stockholders shall be insufficient to pay the holders of shares of Series D Preferred Stock the
full amount to which they shall be entitled under this Subsection 2.1, the holders of shares of Series D Preferred Stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts
which would otherwise be payable in respect of the shares held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full. 

2.2 Payments to Holders of Common Stock. In the event of any voluntary or involuntary liquidation, dissolution or winding up of the
Corporation, after the payment of all preferential amounts required to be paid to the holders of shares of Series D Preferred Stock and subject to any other distribution that may be required with respect to any other series of Preferred Stock, the
remaining assets of the Corporation available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock and any class or series of capital stock that participates with the Common Stock in such
distributions. 
 3. Voting. On any matter presented to the stockholders of the Corporation for their action or consideration at any
meeting of stockholders of the Corporation, each holder of outstanding shares of Series D Preferred Stock shall be entitled to cast a number of votes equal to the number of whole shares of Common Stock into which the shares of Series D Preferred
Stock held by such holder are convertible as of the record date for determining stockholders entitled to vote on such matter. Except as provided by law or by the other provisions of the Certificate of Incorporation, holders of Series D Preferred
Stock shall vote together with the holders of Common Stock as a single class. 
 4. Optional Conversion. 

The holders of the Series D Preferred Stock shall have conversion rights as follows (the “Conversion Rights”): 

4.1 Right to Convert. 

4.1.1 Conversion Ratio. Each share of Series D Preferred Stock shall be convertible, at the option of the holder thereof, at any time
and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series D Original Issue Price by the Series D
Conversion Price (as defined below) in effect at the time of conversion. The “Series D Conversion Price” shall initially be equal to $1.6275. Such initial Series D Conversion Price, and the rate at which shares of Series D Preferred
Stock may be converted into shares of Common Stock, shall be subject to adjustment as provided below. Notwithstanding the foregoing, the Corporation shall not effect any conversion of such holder’s Series D Preferred Stock and such holder shall
not be entitled to convert its shares of Series D Preferred Stock for a 

  
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number of shares of Common Stock in excess of that number of shares of Common Stock which, upon giving effect to such conversion, would cause (a) the aggregate number of shares of Common
Stock beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act to
exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Corporation (including for such purpose the shares of Common Stock issuable upon conversion of the Series D Preferred Stock) following such conversion, or
(b) the combined voting power of the securities of the Corporation beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the
holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined voting power of all of the securities of the Corporation then outstanding following such conversion, unless, in either case, the Corporation
obtains the requisite stockholder approval under NASDAQ Marketplace Rule 5635(b) unless the Corporation obtains the requisite stockholder approval under NASDAQ Marketplace Rule 5635(b), in which case, this limitation under this Section 4.1.1
shall no longer apply to the holder. For purposes of this Section 4.1.1, the aggregate number of shares of Common Stock or voting securities beneficially owned by the holder and its affiliates and any other persons whose beneficial ownership of
Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act shall include the shares of Common Stock issuable upon the conversion of the Series D Preferred Stock with respect to which such
determination is being made, but shall exclude the number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or
non-cancelled portion of any other securities of the Corporation that do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire
at any time Common Stock, including without limitation any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to
receive, Common Stock), subject to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be
aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act. 
 4.1.2 Termination of Conversion Rights.
In the event of a notice of redemption of any shares of Series D Preferred Stock pursuant to Section 5 or 6, the Conversion Rights of the shares designated for redemption shall terminate at the close of business on the last full
day preceding the date fixed for redemption, unless the redemption price is not fully paid on such redemption date, in which case the Conversion Rights for such shares shall continue until such price is paid in full. In the event of a liquidation,
dissolution or winding up of the Corporation, the Conversion Rights shall terminate at the close of business on the last full day preceding the date fixed for the payment of any such amounts distributable on such event to the holders of Series D
Preferred Stock. 
 4.2 Fractional Shares. No fractional shares of Common Stock shall be issued upon conversion of the Series D
Preferred Stock. In lieu of any fractional shares to which the holder would otherwise be entitled, the Corporation shall pay cash equal to such fraction multiplied by the Market Price of a share of Common Stock. Whether or not fractional shares
would be issuable upon such conversion shall be determined on the basis of the total number of 

  
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shares of Series D Preferred Stock the holder is at the time converting into Common Stock and the aggregate number of shares of Common Stock issuable upon such conversion. The “Market
Price” of the Common Stock shall be determined as follows: if the Common Stock is listed on a national securities exchange or another nationally recognized trading system, the Market Price per share of Common Stock shall be deemed to be the
greater of (a) the 20 consecutive trading day average closing price per share of the Corporation’s common stock ending on the trading day immediately prior to the date of determination and (b) the closing price of the
Corporation’s common stock on the trading day immediately prior to the date of determination; and if the Common Stock is not listed on a national securities exchange or another nationally recognized trading system, the Market Price per share of
Common Stock shall be deemed to be the amount most recently determined by the Board of Directors of the Corporation to represent the fair market value per share of the Common Stock (including without limitation a determination for purposes of
granting Common Stock options or issuing Common Stock under any plan, agreement or arrangement with employees of the Company). Upon request of a holder of Series D Preferred Stock, the Board of Directors (or a representative thereof) shall, as
promptly as reasonably practicable but in any event not later than 10 days after such request, notify the holder of the Market Price and furnish the holder with reasonable documentation of the Board’s determination of such Market Price.
Notwithstanding the foregoing, if the Board has not made such a determination within the three-month period prior to the date of determination, then the Board shall make, and shall provide or cause to be provided to the holder notice of, a
determination of the Market Price within 15 days of a request by the holder that it do so. 
 4.3 Mechanics of Conversion. 

4.3.1 Notice of Conversion. In order for a holder of Series D Preferred Stock to voluntarily convert shares of Series D Preferred Stock
into shares of Common Stock, such holder shall surrender the certificate or certificates for such shares of Series D Preferred Stock (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate
affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate), at the office of the
transfer agent for the Series D Preferred Stock (or at the principal office of the Corporation if the Corporation serves as its own transfer agent), together with written notice that such holder elects to convert all or any number of the shares of
the Series D Preferred Stock represented by such certificate or certificates and, if applicable, any event on which such conversion is contingent. Such notice shall state such holder’s name or the names of the nominees in which such holder
wishes the certificate or certificates for shares of Common Stock to be issued. If required by the Corporation, certificates surrendered for conversion shall be endorsed or accompanied by a written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or his, her or its attorney duly authorized in writing. The close of business on the date of receipt by the transfer agent (or by the Corporation if the Corporation serves as
its own transfer agent) of such certificates (or lost certificate affidavit and agreement) and notice shall be the time of conversion (the “Conversion Time”), and the shares of Common Stock issuable upon conversion of the shares
represented by such certificate shall be deemed to be outstanding of record as of such date. The Corporation shall, as soon as practicable after the Conversion Time, (i) issue and deliver to such holder of Series D Preferred Stock, or to his,
her or its nominees, a certificate or certificates for the number of full shares of Common Stock 

  
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 issuable upon such conversion in accordance with the provisions hereof and a certificate for the number (if any)
of the shares of Series D Preferred Stock represented by the surrendered certificate that were not converted into Common Stock, (ii) pay in cash such amount as provided in Subsection 4.2 in lieu of any fraction of a share of Common Stock
otherwise issuable upon such conversion and (iii) pay all accrued or declared but unpaid dividends on the shares of Series D Preferred Stock converted. 

4.3.2 Reservation of Shares. The Corporation shall at all times when the Series D Preferred Stock shall be outstanding, reserve and
keep available out of its authorized but unissued capital stock, for the purpose of effecting the conversion of the Series D Preferred Stock, such number of its duly authorized shares of Common Stock as shall from time to time be sufficient to
effect the conversion of all outstanding Series D Preferred Stock; and if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient to effect the conversion of all then outstanding shares of the Series D
Preferred Stock, the Corporation shall take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock to such number of shares as shall be sufficient for such purposes, including, without limitation,
engaging in best efforts to obtain the requisite stockholder approval of any necessary amendment to the Certificate of Incorporation. Before taking any action which would cause an adjustment reducing the Series D Conversion Price below the then par
value of the shares of Common Stock issuable upon conversion of the Series D Preferred Stock, the Corporation will take any corporate action which may, in the opinion of its counsel, be necessary in order that the Corporation may validly and legally
issue fully paid and nonassessable shares of Common Stock at such adjusted Series D Conversion Price. 
 4.3.3 Effect of Conversion.
All shares of Series D Preferred Stock which shall have been surrendered for conversion as herein provided shall no longer be deemed to be outstanding and all rights with respect to such shares shall immediately cease and terminate at the Conversion
Time, except only the right of the holders thereof to receive shares of Common Stock in exchange therefor, to receive payment in lieu of any fraction of a share otherwise issuable upon such conversion as provided in Subsection 4.2 and to
receive payment of any dividends accrued or declared but unpaid thereon. Any shares of Series D Preferred Stock so converted shall be retired and cancelled and may not be reissued as shares of such series, and the Corporation may thereafter take
such appropriate action (without the need for stockholder action) as may be necessary to reduce the authorized number of shares of Series D Preferred Stock accordingly. 

4.3.4 No Further Adjustment. Upon any such conversion, no adjustment to the Series D Conversion Price shall be made for any declared
but unpaid dividends on the Series D Preferred Stock surrendered for conversion or on the Common Stock delivered upon conversion. 
 4.3.5
Taxes. The Corporation shall pay any and all issue and other similar taxes that may be payable in respect of any issuance or delivery of shares of Common Stock upon conversion of shares of Series D Preferred Stock pursuant to this
Section 4. The Corporation shall not, however, be required to pay any tax which may be payable in respect of any transfer involved in the issuance and delivery of shares of Common Stock in a name other than that in which the shares of
Series D Preferred Stock so converted were registered, and no 

  
 - 7 - 

 
such issuance or delivery shall be made unless and until the person or entity requesting such issuance has paid to the Corporation the amount of any such tax or has established, to the
satisfaction of the Corporation, that such tax has been paid. 
 4.4 Adjustments to Series D Conversion Price for Diluting Issues.

 4.4.1 Special Definitions. For purposes of this Article Fourth, the following definitions shall apply: 

(a) “Option” shall mean rights, options or warrants to subscribe for, purchase or otherwise acquire Common Stock or
Convertible Securities. 
 (b) “Series D Original Issue Date” shall mean the date on which the first share of Series D
Preferred Stock was issued. 
 (c) “Convertible Securities” shall mean any evidences of indebtedness, shares or other
securities directly or indirectly convertible into or exchangeable for Common Stock, but excluding Options. 
 (d) “Additional
Shares of Common Stock” shall mean all shares of Common Stock issued (or, pursuant to Subsection 4.4.3 below, deemed to be issued) by the Corporation after the Series D Original Issue Date, other than (1) the following shares of
Common Stock and (2) shares of Common Stock deemed issued pursuant to the following Options and Convertible Securities (clauses (1) and (2), collectively, “Exempted Securities”): 

 

	 	(i)	shares of Common Stock, Options or Convertible Securities issued as a dividend or distribution on Series D Preferred Stock; 

  

	 	(ii)	shares of Common Stock, Options or Convertible Securities issued by reason of a dividend, stock split, split-up or other distribution on shares of Common Stock that is covered by
Subsection 4.5, 4.6, 4.7 or 4.8; 

  

	 	(iii)	shares of Common Stock or Options issued to employees or directors of, or consultants or advisors to, the Corporation or any of its subsidiaries pursuant to a plan, agreement or arrangement approved by the Board of
Directors of the Corporation; 

  

	 	(iv)	shares of Common Stock or Convertible Securities actually issued upon the exercise of Options or shares of Common Stock actually issued upon the conversion or exchange of Convertible Securities, in each case provided
such issuance is pursuant to the terms of such Option or Convertible Security; 

  
 - 8 - 

	 	(v)	shares of Common Stock, Options or Convertible Securities issued as payments of interest on notes or other indebtedness of the Company; 

 

	 	(vi)	shares of Common Stock, Options or Convertible Securities issued to banks, equipment lessors or other financial institutions, or to real property lessors, pursuant to a debt financing, equipment leasing or real property
leasing transaction approved by the Board of Directors of the Corporation; 

  

	 	(vii)	shares of Common Stock, Options or Convertible Securities issued to suppliers or third party service providers in connection with the provision of goods or services, including placement agents, pursuant to transactions
approved by the Board of Directors of the Corporation; 

  

	 	(viii)	shares of Common Stock, Options or Convertible Securities issued pursuant to the acquisition of another corporation by the Corporation by merger, purchase of substantially all of the assets or other reorganization or to
a joint venture agreement, provided, that such issuances are approved by the Board of Directors of the Corporation; or 

  

	 	(ix)	shares of Common Stock, Options or Convertible Securities issued in connection with sponsored research, collaboration, technology license, development, marketing or other similar agreements or strategic partnerships
approved by the Board of Directors of the Corporation. 

 4.4.2 No Adjustment of Series D Conversion Price. No
adjustment in the Series D Conversion Price shall be made as the result of the issuance or deemed issuance of Additional Shares of Common Stock if the Corporation receives written notice from the Requisite Holders agreeing that no such adjustment
shall be made as the result of the issuance or deemed issuance of such Additional Shares of Common Stock. The term “Requisite Holders” shall mean the holders of at least a majority of the then outstanding shares of Series D Preferred
Stock. 
 4.4.3 Deemed Issue of Additional Shares of Common Stock. 

(a) If the Corporation at any time or from time to time after the Series D Original Issue Date shall issue any Options or Convertible
Securities (excluding Options or Convertible Securities which are themselves Exempted Securities) or shall fix a record date for the determination of holders of any class of securities entitled to receive any such

  
 - 9 - 

 
Options or Convertible Securities, then the maximum number of shares of Common Stock (as set forth in the instrument relating thereto, assuming the satisfaction of any conditions to
exercisability, convertibility or exchangeability but without regard to any provision contained therein for a subsequent adjustment of such number) issuable upon the exercise of such Options or, in the case of Convertible Securities and Options
therefor, the conversion or exchange of such Convertible Securities, shall be deemed to be Additional Shares of Common Stock issued as of the time of such issue or, in case such a record date shall have been fixed, as of the close of business on
such record date. 
 (b) If the terms of any Option or Convertible Security, the issuance of which resulted in an adjustment to the Series D
Conversion Price pursuant to the terms of Subsection 4.4.4, are revised as a result of an amendment to such terms or any other adjustment pursuant to the provisions of such Option or Convertible Security (but excluding automatic adjustments
to such terms pursuant to anti-dilution or similar provisions of such Option or Convertible Security) to provide for either (1) any increase or decrease in the number of shares of Common Stock issuable upon the exercise, conversion and/or
exchange of any such Option or Convertible Security or (2) any increase or decrease in the consideration payable to the Corporation upon such exercise, conversion and/or exchange, then, effective upon such increase or decrease becoming
effective, the Series D Conversion Price computed upon the original issue of such Option or Convertible Security (or upon the occurrence of a record date with respect thereto) shall be readjusted to such Series D Conversion Price as would have
obtained had such revised terms been in effect upon the original date of issuance of such Option or Convertible Security. Notwithstanding the foregoing, no readjustment pursuant to this clause (b) shall have the effect of increasing the
Series D Conversion Price to an amount which exceeds the lower of (i) the Series D Conversion Price in effect immediately prior to the original adjustment made as a result of the issuance of such Option or Convertible Security, or (ii) the
Series D Conversion Price that would have resulted from any issuances of Additional Shares of Common Stock (other than deemed issuances of Additional Shares of Common Stock as a result of the issuance of such Option or Convertible Security) between
the original adjustment date and such readjustment date. 
 (c) If the terms of any Option or Convertible Security (excluding Options or
Convertible Securities which are themselves Exempted Securities), the issuance of which did not result in an adjustment to the Series D Conversion Price pursuant to the terms of Subsection 4.4.4 (either because the consideration per share
(determined pursuant to Subsection 4.4.5) of the Additional Shares of Common Stock subject thereto was equal to or greater than the Series D Conversion Price then in effect, or because such Option or Convertible Security was issued before the
Series D Original Issue Date), are revised after the Series D Original Issue Date as a result of an amendment to such terms or any other adjustment pursuant to the provisions of such Option or Convertible Security (but excluding automatic
adjustments to such terms pursuant to anti-dilution or similar provisions of such Option or Convertible Security) to provide for either (1) any increase in the number of shares of Common Stock issuable upon the exercise, conversion or exchange
of any such Option or Convertible Security or (2) any decrease in the consideration payable to the Corporation upon such exercise, conversion or exchange, then such Option or Convertible Security, as so amended or adjusted, and the Additional
Shares of Common Stock subject thereto (determined in the manner provided in Subsection 4.4.3(a)) shall be deemed to have been issued effective upon such increase or decrease becoming effective. 

  
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 (d) Upon the expiration or termination of any unexercised Option or unconverted or unexchanged
Convertible Security (or portion thereof) which resulted (either upon its original issuance or upon a revision of its terms) in an adjustment to the Series D Conversion Price pursuant to the terms of Subsection 4.4.4, the Series D Conversion
Price shall be readjusted to such Series D Conversion Price as would have obtained had such Option or Convertible Security (or portion thereof) never been issued. 

(e) If the number of shares of Common Stock issuable upon the exercise, conversion and/or exchange of any Option or Convertible Security, or
the consideration payable to the Corporation upon such exercise, conversion and/or exchange, is calculable at the time such Option or Convertible Security is issued or amended but is subject to adjustment based upon subsequent events, any adjustment
to the Series D Conversion Price provided for in this Subsection 4.4.3 shall be effected at the time of such issuance or amendment based on such number of shares or amount of consideration without regard to any provisions for subsequent
adjustments (and any subsequent adjustments shall be treated as provided in clauses (b) and (c) of this Subsection 4.4.3). If the number of shares of Common Stock issuable upon the exercise, conversion and/or exchange of any Option
or Convertible Security, or the consideration payable to the Corporation upon such exercise, conversion and/or exchange, cannot be calculated at all at the time such Option or Convertible Security is issued or amended, any adjustment to the Series D
Conversion Price that would result under the terms of this Subsection 4.4.3 at the time of such issuance or amendment shall instead be effected at the time such number of shares and/or amount of consideration is first calculable (even if
subject to subsequent adjustments), assuming for purposes of calculating such adjustment to the Series D Conversion Price that such issuance or amendment took place at the time such calculation can first be made. 

4.4.4 Adjustment of Series D Conversion Price Upon Issuance of Additional Shares of Common Stock. In the event the Corporation shall at
any time after the Series D Original Issue Date issue Additional Shares of Common Stock (including Additional Shares of Common Stock deemed to be issued pursuant to Subsection 4.4.3), without consideration or for a consideration per share
less than $1.46 (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Common Stock), then the Series D Conversion Price shall be reduced, concurrently
with such issue, to a price (calculated to the nearest one-hundredth of a cent) determined in accordance with the formula below; provided, however that in no event shall the Series D Conversion Price
hereunder be reduced under this Section 4.4.4 to a price that is less than $1.46 (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Common
Stock): 
 CP2 = CP1* (A + B)
÷ (A + C). 
 For purposes of the foregoing formula, the following definitions shall apply: 

  
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 (a) “CP2” shall mean the
Series D Conversion Price in effect immediately after such issue of Additional Shares of Common Stock 
 (b) “CP1” shall mean the Series D Conversion Price in effect immediately prior to such issue of Additional Shares of Common Stock; 

(c) “A” shall mean the number of shares of Common Stock outstanding immediately prior to such issue of Additional Shares of Common
Stock (treating for this purpose as outstanding all shares of Common Stock issuable upon exercise of Options outstanding immediately prior to such issue or upon conversion or exchange of Convertible Securities (including the Series D Preferred
Stock) outstanding (assuming exercise of any outstanding Options therefor) immediately prior to such issue); 
 (d) “B” shall mean
the number of shares of Common Stock that would have been issued if such Additional Shares of Common Stock had been issued at a price per share equal to CP1 (determined by dividing the
aggregate consideration received by the Corporation in respect of such issue by CP1); and 

(e) “C” shall mean the number of such Additional Shares of Common Stock issued in such transaction. 

4.4.5 Determination of Consideration. For purposes of this Subsection 4.4, the consideration received by the Corporation for the
issue of any Additional Shares of Common Stock shall be computed as follows: 
 (a) Cash and Property: Such consideration shall: 

 

	 	(i)	insofar as it consists of cash, be computed at the aggregate amount of cash received by the Corporation, excluding amounts paid or payable for accrued interest; 

 

	 	(ii)	insofar as it consists of property other than cash, be computed at the fair market value thereof at the time of such issue, as determined in good faith by the Board of Directors of the Corporation; and

  

	 	(iii)	in the event Additional Shares of Common Stock are issued together with other shares or securities or other assets of the Corporation for consideration which covers both, be the proportion of such consideration so
received, computed as provided in clauses (i) and (ii) above, as determined in good faith by the Board of Directors of the Corporation. 

(b) Options and Convertible Securities. The consideration per share received by the Corporation for Additional Shares of Common Stock
deemed to have been issued pursuant to Subsection 4.4.3, relating to Options and Convertible Securities, shall be determined by dividing 

  
 - 12 - 

	 	(i)	the total amount, if any, received or receivable by the Corporation as consideration for the issue of such Options or Convertible Securities, plus the minimum aggregate amount of additional consideration (as set forth
in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such consideration) payable to the Corporation upon the exercise of such Options or the conversion or exchange of such Convertible
Securities, or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible Securities, by 

 

	 	(ii)	the maximum number of shares of Common Stock (as set forth in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such number) issuable upon the exercise of
such Options or the conversion or exchange of such Convertible Securities, or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible Securities.

 4.4.6 Multiple Closing Dates. In the event the Corporation shall issue on more than one date Additional Shares of
Common Stock that are a part of one transaction or a series of related transactions and that would result in an adjustment to the Series D Conversion Price pursuant to the terms of Subsection 4.4.4, and such issuance dates occur within a
period of no more than 90 days from the first such issuance to the final such issuance, then, upon the final such issuance, the Series D Conversion Price shall be readjusted to give effect to all such issuances as if they occurred on the date of the
first such issuance (and without giving effect to any additional adjustments as a result of any such subsequent issuances within such period). 

4.5 Adjustment for Stock Splits and Combinations. If the Corporation shall at any time or from time to time after the Series D Original
Issue Date effect a subdivision of the outstanding Common Stock, the Series D Conversion Price in effect immediately before that subdivision shall be proportionately decreased so that the number of shares of Common Stock issuable on conversion of
each share of such series shall be increased in proportion to such increase in the aggregate number of shares of Common Stock outstanding. If the Corporation shall at any time or from time to time after the Series D Original Issue Date combine the
outstanding shares of Common Stock, the Series D Conversion Price in effect immediately before the combination shall be proportionately increased so that the number of shares of 

  
 - 13 - 

 
Common Stock issuable on conversion of each share of such series shall be decreased in proportion to such decrease in the aggregate number of shares of Common Stock outstanding. Any adjustment
under this subsection shall become effective at the close of business on the date the subdivision or combination becomes effective. 
 4.6
Adjustment for Certain Dividends and Distributions. In the event the Corporation at any time or from time to time after the Series D Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common
Stock entitled to receive, a dividend or other distribution payable on the Common Stock in additional shares of Common Stock, then and in each such event the Series D Conversion Price in effect immediately before such event shall be decreased as of
the time of such issuance or, in the event such a record date shall have been fixed, as of the close of business on such record date, by multiplying the Series D Conversion Price then in effect by a fraction: 

 

	 	(1)	the numerator of which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date, and 

 

	 	(2)	the denominator of which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date plus the number of shares
of Common Stock issuable in payment of such dividend or distribution. 

 Notwithstanding the foregoing, (a) if such record date shall
have been fixed and such dividend is not fully paid or if such distribution is not fully made on the date fixed therefor, the Series D Conversion Price shall be recomputed accordingly as of the close of business on such record date and thereafter
the Series D Conversion Price shall be adjusted pursuant to this subsection as of the time of actual payment of such dividends or distributions; and (b) no such adjustment shall be made if the holders of Series D Preferred Stock simultaneously
receive a dividend or other distribution of shares of Common Stock in a number equal to the number of shares of Common Stock as they would have received if all outstanding shares of Series D Preferred Stock had been converted into Common Stock on
the date of such event. 
 4.7 Adjustments for Other Dividends and Distributions. In the event the Corporation at any time or from
time to time after the Series D Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable in securities of the Corporation (other than
a distribution of shares of Common Stock in respect of outstanding shares of Common Stock) or in other property and the provisions of Section 1 do not apply to such dividend or distribution, then and in each such event the holders of
Series D Preferred Stock shall receive, simultaneously with the distribution to the holders of Common Stock, a dividend or other distribution of such securities or other property in an amount equal to the amount of such securities or other property
as they would have received if all outstanding shares of Series D Preferred Stock had been converted into Common Stock on the date of such event. 

  
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 4.8 Adjustment for Merger or Reorganization, etc. If there shall occur any reorganization,
recapitalization, reclassification, consolidation or merger involving the Corporation in which the Common Stock (but not the Series D Preferred Stock) is converted into or exchanged for securities, cash or other property (other than a transaction
covered by Subsections 4.4, 4.6 or 4.7), then, following any such reorganization, recapitalization, reclassification, consolidation or merger, each share of Series D Preferred Stock shall thereafter be convertible in lieu of the
Common Stock into which it was convertible prior to such event into the kind and amount of securities, cash or other property which a holder of the number of shares of Common Stock of the Corporation issuable upon conversion of one share of Series D
Preferred Stock immediately prior to such reorganization, recapitalization, reclassification, consolidation or merger would have been entitled to receive pursuant to such transaction; and, in such case, appropriate adjustment (as determined in good
faith by the Board of Directors of the Corporation) shall be made in the application of the provisions in this Section 4 with respect to the rights and interests thereafter of the holders of the Series D Preferred Stock, to the end that
the provisions set forth in this Section 4 (including provisions with respect to changes in and other adjustments of the Series D Conversion Price) shall thereafter be applicable, as nearly as reasonably may be, in relation to any
securities or other property thereafter deliverable upon the conversion of the Series D Preferred Stock. 
 4.9 Certificate as to
Adjustments. Upon the occurrence of each adjustment or readjustment of the Series D Conversion Price pursuant to this Section 4, the Corporation at its expense shall, as promptly as reasonably practicable but in any event not later
than 10 days thereafter, compute such adjustment or readjustment in accordance with the terms hereof and furnish to each holder of Series D Preferred Stock a certificate setting forth such adjustment or readjustment (including the kind and amount of
securities, cash or other property into which the Series D Preferred Stock is convertible) and showing in detail the facts upon which such adjustment or readjustment is based. The Corporation shall, as promptly as reasonably practicable after the
written request at any time of any holder of Series D Preferred Stock (but in any event not later than 10 days thereafter), furnish or cause to be furnished to such holder a certificate setting forth (i) the Series D Conversion Price then in
effect, and (ii) the number of shares of Common Stock and the amount, if any, of other securities, cash or property which then would be received upon the conversion of Series D Preferred Stock. 

4.10 Notice of Record Date. In the event: 

(a) the Corporation shall take a record of the holders of its Common Stock (or other capital stock or securities at the time issuable upon
conversion of the Series D Preferred Stock) for the purpose of entitling or enabling them to receive any dividend or other distribution, or to receive any right to subscribe for or purchase any shares of capital stock of any class or any other
securities, or to receive any other security; or 
 (b) of any capital reorganization of the Corporation, any reclassification of the Common
Stock of the Corporation, or any consolidation or merger of the Corporation; or 
 (c) of the voluntary or involuntary dissolution,
liquidation or winding-up of the Corporation, 

  
 - 15 - 

 then, and in each such case, the Corporation will send or cause to be sent to the holders of the Series D
Preferred Stock a notice specifying, as the case may be, (i) the record date for such dividend, distribution or right, and the amount and character of such dividend, distribution or right, or (ii) the effective date on which such
reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation or winding-up is proposed to take place, and the time, if any is to be fixed, as of which the holders of record of
Common Stock (or such other capital stock or securities at the time issuable upon the conversion of the Series D Preferred Stock) shall be entitled to exchange their shares of Common Stock (or such other capital stock or securities) for securities
or other property deliverable upon such reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation or winding-up, and the amount per share and character of such exchange
applicable to the Series D Preferred Stock and the Common Stock. Such notice shall be sent at least 10 days prior to the record date or effective date for the event specified in such notice. 

5. Redemption by Corporation. 

5.1 Redemption. Shares of Series D Preferred Stock may be redeemed by the Corporation out of funds lawfully available therefor at a
price equal to the Series D Original Issue Price per share, plus all accrued or declared but unpaid dividends thereon (the “Redemption Price”), at any time after November 4, 2013, if the closing sales price of the Common Stock
for 20 or more trading days in a period of 30 consecutive trading days is equal to or greater than 200% of the Series D Conversion Price, provided that the Corporation provides written notice of such redemption to each holder of Series D Preferred
Stock within 30 days of the end of such 30 consecutive trading day period (the “Redemption Notice”). The Corporation shall send the Redemption Notice to each holder of record of Series D Preferred Stock not less than 30 days prior
to the date fixed by the Corporation for such redemption (the “Redemption Date”). The Redemption Notice shall state: 
 (a)
the Redemption Date and the Redemption Price; 
 (b) the date upon which the holder’s right to convert such shares terminates (as
determined in accordance with Subsection 4.1); and 
 (c) that the holder is to surrender to the Corporation, in the manner and at
the place designated, his, her or its certificate or certificates representing the shares of Series D Preferred Stock to be redeemed. 
 5.2
Surrender of Certificates; Payment. On or before the Redemption Date, each holder of shares of Series D Preferred Stock, unless such holder has exercised his, her or its right to convert such shares as provided in Section 4, shall
surrender the certificate or certificates representing such shares (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation
to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate) to the Corporation, in the manner and at the place designated in the Redemption Notice,
and thereupon the Redemption Price for such shares shall be payable to the order of the person whose name appears on such certificate or certificates as the owner thereof. 

  
 - 16 - 

 5.3 Rights Subsequent to Redemption. If the Redemption Notice shall have been duly given,
and if on the Redemption Date the Redemption Price payable upon redemption of the shares of Series D Preferred Stock is paid or tendered for payment or deposited with an independent payment agent so as to be available therefor in a timely manner,
then notwithstanding that the certificates evidencing any of the shares of Series D Preferred Stock so called for redemption shall not have been surrendered, dividends with respect to such shares of Series D Preferred Stock shall cease to accrue
after such Redemption Date and all rights with respect to such shares shall forthwith after the Redemption Date terminate, except only the right of the holders to receive the Redemption Price without interest upon surrender of their certificate or
certificates therefor. 
 6. Fundamental Change Redemption. 

6.1 Fundamental Change. Upon the occurrence of a Fundamental Change, each holder of shares of Series D Preferred Stock may, at its sole
option, require the Corporation to purchase all or a portion of its shares of Series D Preferred Stock (the “Fundamental Change Redemption”) at a price equal to Redemption Price. A “Fundamental Change” shall mean any of
the following events: 
 (a) any “person” or “group” (each term as defined in the Exchange Act) that is not an affiliate
of any holder of shares of Series D Preferred Stock becoming the “beneficial owner” (as defined in the Exchange Act) of voting securities of the Corporation, representing 66 2/3% or more of the outstanding voting securities of the
Corporation (treating all securities convertible or exchangeable into or exercisable for shares of Common Stock as having been fully converted, exchanged and exercised, without regard to any exercise, conversion or exchange limitations therein)
other than in connection with a transaction described in clause (d) below; 
 (b) the recapitalization or reclassification of the
Common Stock of the Corporation; 
 (c) a sale of all or substantially all of the assets of the Corporation’s assets to a person that
is not an affiliate of any holder of shares of Series D Preferred Stock; or 
 (d) a merger, consolidation, business combination or similar
transaction the result of which a “person” or “group” (each as defined in the Exchange Act) that is not an affiliate of any holder of shares of Series D Preferred Stock owns voting securities representing 66 2/3% or more of the
outstanding voting securities of the surviving entity upon completion of such transaction. 
 6.2 Exercise of Fundamental Change
Redemption Option. The Company shall send a written notice (the “Fundamental Change Notice”) to each holder of shares of Series D Preferred Stock of (i) the occurrence of a Fundamental Change described in Subsection
6.1(a) above, within 10 days of the Corporation’s becoming aware of the occurrence of such Fundamental Change, and (ii) a Fundamental Change described in Subsection 6.1(b)-(d) above,
in accordance with Section 4.10. The Fundamental Change Notice shall describe the 

  
 - 17 - 

 
Fundamental Change and state that each holder of shares of Series D Preferred Stock has the right to require a Fundamental Change Redemption. In order to require a Fundamental Change Redemption,
a holder of Series D Preferred Stock must deliver written notice to the Corporation requesting the Fundamental Change Redemption within five days after the date of the Fundamental Change Notice and stating the number of shares of Series D Preferred
Stock to be redeemed. Unless prohibited by Delaware law governing distributions to stockholders, the Corporation shall redeem the shares of Series D Preferred Stock requested to be redeemed at a price equal to the Redemption Price and on a date to
be fixed by the Corporation which shall not be more than 30 days from the date of the last timely delivered Fundamental Change Redemption request. If, on the date of the Fundamental Change Redemption, Delaware law governing distributions to
stockholders prevents the Corporation from redeeming all shares of Series D Preferred Stock to be redeemed, the Corporation shall ratably redeem the maximum number of shares that it may redeem consistent with such law, and shall redeem the remaining
shares as soon as it may lawfully do so under such law. 
 6.3 Redemption Notice. Following receipt of a timely request for a
Fundamental Change Redemption by a holder of Series D Preferred Stock, the Corporation shall send written notice of the mandatory redemption to the holder stating: 

(a) the date fixed for the Fundamental Redemption (the “Fundamental Redemption Date”) and the Redemption Price; 

(b) the date upon which the holder’s right to convert such shares terminates (as determined in accordance with Subsection 4.1);
and 
 (c) that the holder is to surrender to the Corporation, in the manner and at the place designated, his, her or its certificate or
certificates representing the shares of Series D Preferred Stock to be redeemed. 
 6.4 Surrender of Certificates; Payment. On or
before the Fundamental Redemption Date, each holder of shares of Series D Preferred Stock to be redeemed on such Redemption Date, unless such holder has exercised his, her or its right to convert such shares as provided in Section 4,
shall surrender the certificate or certificates representing such shares (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the
Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate) to the Corporation, in the manner and at the place designated in the notice
from the Corporation, and thereupon the Redemption Price for such shares shall be payable to the order of the person whose name appears on such certificate or certificates as the owner thereof. In the event less than all of the shares of Series D
Preferred Stock represented by a certificate are redeemed, a new certificate representing the unredeemed shares of Series D Preferred Stock shall promptly be issued to such holder. 

6.5 Rights Subsequent to Redemption. If on the Fundamental Redemption Date the Redemption Price payable upon redemption of the shares of
the Series D Preferred Stock to be redeemed on such Redemption Date is paid or tendered for payment or deposited with an independent payment agent so as to be available therefor in a timely manner, then

  
 - 18 - 

 
notwithstanding that the certificates evidencing any of the shares of Series D Preferred Stock so called for redemption shall not have been surrendered, dividends with respect to such shares of
Series D Preferred Stock shall cease to accrue after such Redemption Date and all rights with respect to such shares shall forthwith after the Fundamental Redemption Date terminate, except only the right to the holders to receive the Redemption
Price without interest upon surrender of their certificate or certificates therefor. 
 6.6 Fundamental Change and Dividends. Upon the
occurrence of a Fundamental Change as described in Subsection 6.1(c)-(d), the Company’s obligation to pay Series D Preferred Dividends shall terminate. 

7. Redeemed or Otherwise Acquired Shares. Any shares of Series D Preferred Stock that are redeemed or otherwise acquired by the
Corporation or any of its subsidiaries shall be automatically and immediately cancelled and retired and shall not be reissued, sold or transferred. Neither the Corporation nor any of its subsidiaries may exercise any voting or other rights granted
to the holders of Series D Preferred Stock following redemption. 
 8. Waiver. Any of the rights, powers, preferences and other terms
of the Series D Preferred Stock set forth herein may be waived on behalf of all holders of Series D Preferred Stock by the affirmative written consent or vote of the Requisite Holders. 

9. Notices. Any notice required or permitted to be given to a holder of shares of Series D Preferred Stock shall be mailed, postage
prepaid, to the post office address last shown on the records of the Corporation, or given by electronic communication in compliance with the provisions of the General Corporation Law, and shall be deemed sent upon such mailing or electronic
transmission. 
 IN WITNESS WHEREOF, this Certificate of Designations has been executed by a duly authorized officer of this
corporation on this 4th day of November, 2011. 
  

			
	By:	 	/s/ Sudhir Agrawal
		 	Chief Executive Officer

  
 - 19 - 

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED
CERTIFICATE OF INCORPORATION 
 OF 

IDERA PHARMACEUTICALS, INC. 

Idera Pharmaceuticals, Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General
Corporation Law of the State of Delaware, does hereby certify as follows: 
 By action of the Board of Directors of the Corporation at a
meeting held on March 27, 2012, the Board of Directors of the Corporation duly adopted a resolution, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the Restated Certificate of
Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in accordance with
Section 242 of the General Corporation Law of the State of Delaware at a meeting of stockholders held on June 12, 2012. The resolution setting forth the amendment is as follows: 

RESOLVED: That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in
its entirety so that the same shall read as follows: 
 “FOURTH. The total number of shares of all classes of stock which the
Corporation shall have authority to issue is (i) One Hundred Forty Million (140,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred
Stock, $.01 par value per share (“Preferred Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its duly authorized officer this 13th day of
June, 2012. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	/s/ Sudhir Agrawal
		 	Chief Executive Officer

 CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS 

OF 
 SERIES E PREFERRED
STOCK 
 OF 

IDERA PHARMACEUTICALS, INC. 

(Pursuant to Section 151 of 

the Delaware General Corporation Law) 

Idera Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under the laws of the State of
Delaware, hereby certifies that, pursuant to authority conferred on its Board of Directors (the “Board”) by the Restated Certificate of Incorporation of the Corporation, as amended (the “Certificate of
Incorporation”), the following resolution was adopted by the Board at a meeting duly called and held on November 9, 2012, which resolution remains in full force and effect on the date hereof: 

RESOLVED, that there is hereby created and established a series of the Corporation’s authorized Preferred Stock (the “Preferred
Stock”) having a par value of $0.01 per share, which series shall be designated as “Series E Convertible Preferred Stock” (the “Series E Preferred Stock”) and shall consist of 424,242 shares. The shares of Series
E Preferred Stock shall have the voting powers, designations, preferences and other special rights, and qualifications, limitations and restrictions thereof set forth below: 

1. Dividends. 
 1.1 Each
holder of Series E Preferred Stock shall be entitled to receive with respect to each share of Series E Preferred Stock then outstanding and held by such holder of Series E Preferred Stock, dividends, commencing from the date of issuance of such
share of Series E Preferred Stock, at the Initial Dividend Rate (as defined below) per annum (on the basis of a 360 day year) of the Series E Original Issue Price (as defined below) (the “Series E Preferred Dividends”); provided,
however, that subject to and effective upon the filing with the Delaware Secretary of State of the amendment to the Certificate of Designations, Preferences and Rights of Series D Preferred Stock (the “Series D Certificate of
Designations,” with the amendment thereto being referred to as the “Amendment to Series D Certificate of Designations”) as described in Section 5.11(B) of that certain Convertible Preferred Stock and Warrant Purchase
Agreement, dated November 9, 2012, between the Corporation and the purchasers of the Series E Preferred Stock therein (the “Series E Purchase Agreement”), the dividend rate provided for in this Section 1.1 shall be
increased from the Initial Dividend Rate to the rate of eight percent (8%) per annum (on the basis of a 360 day year) of the Series E Original Issue Price. The Series E Preferred Dividends shall be cumulative, whether or not earned or declared,
shall be paid quarterly in arrears on the last day of March, June, September and December (a “Quarterly Dividend Payment Date”) in each year that Series E Preferred Stock is outstanding, with the first Quarterly Dividend Payment
Date being March 31, 2013, and shall be prorated for periods shorter than one 

 
quarter. Notwithstanding the foregoing, if, as of any Quarterly Dividend Payment Date at which the dividend rate is the Initial Dividend Rate, there are no shares of the Corporation’s Series
D Convertible Preferred Stock outstanding, then the dividend payable on such Quarterly Dividend Payment Date shall be calculated and paid at a rate of eight percent (8%) per annum (on the basis of a 360 day year) of the Series E Original Issue
Price. In the event that the Amendment to Series D Certificate of Designations is filed with the Delaware Secretary of State and the dividend rate with respect to the Series E Preferred Dividends is increased pursuant to this Section 1.1, the
Series E Preferred Dividends paid on the first Quarterly Dividend Payment Date after such filing and increase shall be paid at the increased rate. In the event that the Amendment to Series D Certificate of Designations is submitted to the
stockholders of the Corporation as contemplated by Section 5.11 of the Series E Purchase Agreement and the Amendment to Series D Certificate of Designations is not approved, then the holders of the Series E Preferred Stock shall no longer be
entitled to any Series E Preferred Dividends under this Section 1.1 and the Corporation shall have no further obligation to pay the Series E Preferred Dividends under this Section 1.1; provided, however, the Corporation shall not submit
the Amendment to the Series D Certificate of Designations to the stockholders if there are no shares of Series D Preferred Stock then outstanding. The rights of a holder of Series E Preferred Stock to Series E Preferred Dividends shall rank senior
to the rights of the Corporation’s Series A Convertible Preferred Stock and Series D Convertible Preferred Stock as to dividends. The Series E Preferred Dividends shall be paid to each holder of Series E Preferred Stock in cash out of legally
available funds. The term “Initial Dividend Rate” shall mean four and six tenths percent (4.6%) or such other percentage approved by the Corporation and by the holders of at least a majority of then outstanding shares of Series
E Preferred Stock, with such approval given in writing or by vote at a meeting, consenting or voting (as the case may be) as a separate class. 

1.2 Notwithstanding the foregoing, if any Series E Preferred Dividend is not paid by the Corporation within five trading days following a
Quarterly Dividend Payment Date, such Series E Preferred Dividend shall continue to accrue and the Corporation shall be obligated to pay the holders a late fee with respect to such Series E Preferred Dividend, which shall be paid by the Corporation
in cash, at the rate of sixteen percent (16%) per annum (or such lesser rate permitted by applicable law) (the “Dividend Late Fee”), and shall accrue daily from the applicable Quarterly Dividend Payment Date through and
including the date the Corporation pays such Series E Preferred Dividend plus the Dividend Late Fee in full (which amount shall be paid as liquidated damages and not as a penalty); provided however, that no Dividend Late Fee shall accrue or
be owed with respect to any Series E Preferred Dividend that the Corporation is not permitted to pay under Delaware law. 
 1.3 The
Corporation shall not declare, pay or set aside any dividends on shares of any other class or series of capital stock of the Corporation (other than dividends on shares of the Corporation’s Common Stock, par value $0.001 per share (the
“Common Stock”) payable in shares of Common Stock, dividends on the Series A Convertible Preferred Stock in accordance with Section 2(a) of the Certificate of Designations, Preferences and Rights of Series A Convertible
Preferred Stock (the “Series A Certificate of Designations”), dividends on the Series D Convertible Preferred Stock in accordance with Section 1.1 of the Series D Certificate of

  
 2 

 
Designations and such dividends on other series or classes of the capital stock of the Corporation as are approved for this exclusion by the holders of at least a majority of the then outstanding
shares of Series E Preferred Stock, given in writing or by vote at a meeting, consenting or voting (as the case may be) as a separate class, unless the holders of the Series E Preferred Stock then outstanding shall first receive, or simultaneously
receive, a dividend on each outstanding share of Series E Preferred Stock in an amount at least equal to the sum of (i) the amount of the aggregate dividends then accrued on such share of Series E Preferred Stock and not previously paid and
(ii) (A) in the case of a dividend on Common Stock or any class or series that is convertible into Common Stock, that dividend per share of Series E Preferred Stock as would equal the product of (1) the dividend payable on each share
of such class or series determined, if applicable, as if all shares of such class or series had been converted into Common Stock and (2) the number of shares of Common Stock issuable upon conversion of a share of Series E Preferred Stock, in
each case calculated on the record date for determination of holders entitled to receive such dividend or (B) in the case of a dividend on any class or series that is not convertible into Common Stock, at a rate per share of Series E Preferred
Stock determined by (1) dividing the amount of the dividend payable on each share of such class or series of capital stock by the original issuance price of such class or series of capital stock (subject to appropriate adjustment in the event
of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (2) multiplying such fraction by an amount equal to the Series E Original Issue Price; provided that, if the
Corporation declares, pays or sets aside, on the same date, a dividend on shares of more than one class or series of capital stock of the Corporation, the dividend payable to the holders of Series E Preferred Stock pursuant to this
Section 1.3 shall be calculated based upon the dividend on the class or series of capital stock that would result in the highest Series E Preferred Stock dividend. 

1.4 The “Series E Original Issue Price” shall mean $14.00 per share, subject to appropriate adjustment in the event of any
stock dividend, stock split, combination or other similar recapitalization with respect to the Series E Preferred Stock. 
 2.
Liquidation, Dissolution or Winding Up; Sale of the Corporation. 
 2.1 Payments to Holders of Series E Preferred Stock Upon
Liquidation. 
 2.1.1 In the event of any voluntary or involuntary liquidation, dissolution or winding up of the Corporation, the
holders of shares of Series E Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders before any payment shall be made to the holders of Common Stock, Series A
Convertible Preferred Stock, Series D Convertible Preferred Stock or any other class of capital stock of the Corporation ranking junior to the Series E Preferred Stock as to liquidation, by reason of their ownership thereof, an amount per share
equal to the greater of (i) the Series E Original Issue Price, plus any dividends accrued or declared but unpaid thereon, and (ii) such amount per share as would have been payable with respect to such share had all shares of Series E
Preferred Stock been converted into Common Stock pursuant to Subsection 4 immediately prior to such liquidation, dissolution or winding up disregarding for these purposes the limitations on conversion due to beneficial ownership set forth in
Subsection 4.1.2. 

  
 3 

 2.1.2 If upon any such liquidation, dissolution or winding up of the Corporation, the assets of
the Corporation available for distribution to its stockholders shall be insufficient to pay the holders of shares of Series E Preferred Stock the full amount to which they shall be entitled under this Subsection 2.1, the holders of shares of
Series E Preferred Stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be payable in respect of the shares held by them upon such distribution if all
amounts payable on or with respect to such shares were paid in full. 
 2.2 Payments to Holders of Common Stock Upon Liquidation. In
the event of any voluntary or involuntary liquidation, dissolution or winding up of the Corporation, after the payment of all preferential amounts required to be paid to the holders of shares of Series E Preferred Stock and subject to any other
distribution that may be required with respect to any other series of Preferred Stock, the remaining assets of the Corporation available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock and any
class or series of capital stock that participates with the Common Stock in such distributions. 
 2.3 Sale of the Corporation. 

2.3.1 In the event of a Sale of the Corporation (as defined below) after payment shall be made to the holders of Series A Convertible
Preferred Stock, Series D Convertible Preferred Stock and any other class of capital stock of the Corporation ranking senior to the Series E Preferred Stock upon a Sale of the Corporation, the remaining assets of the Corporation available for
distribution to its stockholders shall be distributed among the holders of the shares of Series E Preferred Stock and Common Stock pro rata based on the number of shares held by each such holder, treating for this purpose all such securities as if
they had been converted to Common Stock pursuant to the terms of the Certificate of Incorporation immediately prior to such Sale of the Corporation disregarding for these purposes the limitations on conversion due to beneficial ownership set forth
in Subsection 4.1.2. 
 2.3.2 The term “Sale of the Corporation” shall mean each of the following events: (a) a merger
or consolidation in which (i) the Corporation is a constituent party or (ii) a subsidiary of the Corporation is a constituent party and the Corporation issues shares of its capital stock pursuant to such merger or consolidation (except in
the case of clause (i) and (ii), any such merger or consolidation involving the Corporation or a subsidiary in which the shares of capital stock of the Corporation outstanding immediately prior to such merger or consolidation continue to
represent, or are converted into or exchanged for shares of capital stock that represent, immediately following such merger or consolidation, at least a majority, by voting power, of the capital stock of (y) the surviving or resulting
corporation or (z) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or resulting corporation; or
(b) the sale, lease, transfer, exclusive license or other disposition, in a single transaction or series of related transactions, by the Corporation or any subsidiary of the Corporation of all or substantially all the assets of the Corporation
and its subsidiaries taken as a whole, or the sale or disposition (whether by merger or otherwise) of one or more subsidiaries of the Corporation if substantially all of the assets of the 

  
 4 

 
Corporation and its subsidiaries taken as a whole are held by such subsidiary or subsidiaries, except where such sale, lease, transfer, exclusive license or other disposition is to a wholly owned
subsidiary of the Corporation. For the purposes of clarity, a Sale of the Corporation shall not be deemed to be a liquidation, dissolution or winding up of the Corporation for the purposes of this Section 2. 

3. Voting. 
 3.1 Unless and
until the stockholders of the Corporation approve the Nasdaq Proposal (as defined by and in accordance with Section 5.11(B) of the Series E Purchase Agreement), the holders of the Series E Preferred Stock shall have no voting rights with
respect to any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation or otherwise, except as otherwise required by applicable law or regulation. Subject to and
effective upon the date that the stockholders of the Corporation approve the Nasdaq Proposal, on any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation, each
holder of outstanding shares of Series E Preferred Stock shall be entitled to cast a number of votes equal to the lesser of (a) the number of whole shares of Common Stock into which the shares of Series E Preferred Stock held by such holder are
convertible as of the record date for determining stockholders entitled to vote on such matter and (b) the product of the Voting Adjustment Percentage (as defined below) multiplied by the number of whole shares of Common Stock into which the
shares of Series E Preferred Stock held by such holder are convertible as of the record date for determining stockholders entitled to vote on such matter. Except as provided by law or by the other provisions of the Certificate of Incorporation,
holders of Series E Preferred Stock shall vote together, as a single class, with the holders of Common Stock, Series D Convertible Preferred Stock and any other series or class of the stock of the Corporation that votes together with the holders of
Common Stock. The “Voting Adjustment Percentage” is determined in accordance with the formula below: 
  

 
 For purposes of the foregoing formula, the following definitions shall apply: 

(a) “A” shall mean the number of shares of Common Stock then issued and outstanding plus the number of shares of Common Stock then
issuable upon conversion of the Series D Preferred Stock then issued and outstanding and any other series of Preferred Stock (other than the Series E Preferred Stock) then issued and outstanding, and entitled to vote on any matter presented to the
stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation; 

  
 5 

 (b) “B” shall mean the number of shares of Common Stock then issued and outstanding
plus the number of shares of Common Stock then issuable upon conversion of the Series D Preferred Stock then issued and outstanding and any other series of Preferred Stock (other than the Series E Preferred Stock) then issued and outstanding, and
entitled to vote on any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of stockholders of the Corporation, in each case held by any holders of Series E Preferred Stock or an affiliate of any
holders of Series E Preferred Stock; 
 (c) “C” shall mean the number of shares of Common Stock then issuable upon conversion of
the Series E Preferred Stock then issued and outstanding; and 
 (d) “X” shall mean the Voting Adjustment Percentage. 

3.2 Series E Preferred Stock Protective Provisions. At any time when at least 84,849 shares of Series E Preferred Stock (subject to
appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Series E Preferred Stock) are outstanding, the Corporation shall not, either directly or indirectly by
amendment, merger, consolidation or otherwise, do any of the following without (in addition to any other vote required by law or the Certificate of Incorporation) the written consent or affirmative vote of the holders of at least 51% of the then
outstanding shares of Series E Preferred Stock, given in writing or by vote at a meeting, consenting or voting (as the case may be) as a separate class, and any such act or transaction entered into without such consent or vote shall be null and void
ab initio, and of no force or effect: 
 3.2.1 amend, alter or repeal any provision of the Certificate of Incorporation or bylaws of the
Corporation in a manner that adversely and uniquely affects the powers, preferences or rights of the Series E Preferred Stock; 
 3.2.2
purchase or redeem (or permit any subsidiary to purchase or redeem) or pay or declare any dividend or make any distribution on, any shares of capital stock of the Corporation other than (i) redemptions of or dividends or distributions on the
Series A Preferred Stock and Series D Preferred Stock, (ii) dividends or other distributions payable on the Common Stock solely in the form of additional shares of Common Stock, (iii) repurchases of stock from former employees, officers,
directors, consultants or other persons who performed services for the Corporation or any subsidiary in connection with the cessation of such employment or service at the lower of the original purchase price or the then-current fair market value
thereof pursuant to agreements between such persons and the Corporation or (iv) redemptions under Subsection 5 below; or 
 3.2.3
recapitalize or reclassify any of the Common Stock. 

  
 6 

 4. Optional Conversion. 

The holders of the Series E Preferred Stock shall have conversion rights as follows (the “Conversion Rights”): 

4.1 Right to Convert. 

4.1.1 Termination of Conversion Rights. In the event of a notice of redemption of any shares of Series E Preferred Stock pursuant to
Subsection 5, the Conversion Rights of the shares designated for redemption shall terminate at the close of business on the last full day preceding the date fixed for redemption, unless the redemption price is not fully paid on such
redemption date, in which case the Conversion Rights for such shares shall continue until such price is paid in full. In the event of a liquidation, dissolution or winding up of the Corporation or a Sale of the Corporation, the Conversion Rights
shall terminate at the close of business on the last full day preceding the date fixed for the payment of any such amounts distributable on such event to the holders of Series E Preferred Stock. 

4.1.2 Conversion Ratio. Each share of Series E Preferred Stock shall be convertible, at the option of the holder thereof, at any time
and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series E Original Issue Price by the Series E
Conversion Price (as defined below) in effect at the time of conversion. The “Series E Conversion Price” shall initially be equal to $0.70. Such initial Series E Conversion Price, and the rate at which shares of Series E Preferred
Stock may be converted into shares of Common Stock, shall be subject to adjustment as provided below. Notwithstanding the foregoing, the Corporation shall not effect any conversion of such holder’s Series E Preferred Stock and such holder shall
not be entitled to convert its shares of Series E Preferred Stock for a number of shares of Common Stock in excess of that number of shares of Common Stock which, upon giving effect to such conversion, would cause (a) the aggregate number of
shares of Common Stock beneficially owned by a holder of Series E Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of
the Securities Exchange Act of 1934, as amended (the “Exchange Act”) to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Corporation (including for such purpose the shares of Common Stock
issuable upon conversion of the Series E Preferred Stock) following such conversion, or (b) the combined voting power of the securities of the Corporation beneficially owned by a holder of Series E Preferred Stock and its affiliates and any
other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined voting power of all of the securities of the Corporation then
outstanding following such conversion, unless, in either case, the stockholders of the Corporation approve the Nasdaq Proposal, in which case, the 19.99% limitation under clause (a) and clause (b) of this Section 4.1.2 shall be
increased, with respect to any holder of Series E Preferred Stock, to 35% for purposes of both clause (a) and clause (b) of this Section 4.1.2. For purposes of this Section 4.1.2, the aggregate number of shares of
Common Stock or voting securities beneficially owned by the holder and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the

  
 7 

 
Exchange Act shall include the shares of Common Stock issuable upon the conversion of the Series E Preferred Stock with respect to which such determination is being made, but shall exclude the
number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or non-cancelled portion of any other securities
of the Corporation that do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire at any time Common Stock, including without limitation any debt, preferred stock,
right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock), subject to a limitation on conversion or exercise analogous to
the limitation contained herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act.

 4.2 Fractional Shares. No fractional shares of Common Stock shall be issued upon conversion of the Series E Preferred Stock. In
lieu of any fractional shares to which the holder would otherwise be entitled, the Corporation shall pay cash equal to such fraction multiplied by the Market Price of a share of Common Stock. Whether or not fractional shares would be issuable upon
such conversion shall be determined on the basis of the total number of shares of Series E Preferred Stock the holder is at the time converting into Common Stock and the aggregate number of shares of Common Stock issuable upon such conversion. The
“Market Price” of the Common Stock shall be determined as follows: if the Common Stock is listed on a national securities exchange or another nationally recognized trading system, the Market Price per share of Common Stock shall be
deemed to be the greater of (a) the 20 consecutive trading day average closing price per share of the Common Stock ending on the trading day immediately prior to the date of determination and (b) the closing price of the Common Stock on
the trading day immediately prior to the date of determination; and if the Common Stock is not listed on a national securities exchange or another nationally recognized trading system, the Market Price per share of Common Stock shall be deemed to be
the amount most recently determined by the Board to represent the fair market value per share of the Common Stock (including without limitation a determination for purposes of granting Common Stock options or issuing Common Stock under any plan,
agreement or arrangement with employees of the Corporation). Upon request of a holder of Series E Preferred Stock, the Board (or a representative thereof) shall, as promptly as reasonably practicable but in any event not later than 10 days after
such request, notify the holder of the Market Price and furnish the holder with reasonable documentation of the Board’s determination of such Market Price. Notwithstanding the foregoing, if the Board has not made such a determination within the
three-month period prior to the date of determination, then the Board shall make, and shall provide or cause to be provided to the holder notice of, a determination of the Market Price within 15 days of a request by the holder that it do so. 

4.3 Mechanics of Conversion. 

4.3.1 Notice of Conversion. In order for a holder of Series E Preferred Stock to voluntarily convert shares of Series E Preferred Stock
into shares of Common Stock, such holder shall surrender the certificate or certificates for such shares of Series E Preferred Stock (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate
affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate), at the office of the
transfer agent for the Series E Preferred Stock (or at the principal office of the Corporation if the Corporation serves as its own transfer agent), together with written notice that such holder elects to convert all or any number of the shares of
the Series E Preferred Stock represented by such certificate or certificates and, if applicable, any event on which such conversion is contingent. Such notice shall state such holder’s name or the names of the nominees in which such holder
wishes the certificate or certificates for shares of Common Stock to be issued. If required by the Corporation, certificates surrendered for conversion shall be endorsed or accompanied by a written instrument or instruments of transfer, in form
satisfactory to the Corporation, duly executed by the registered holder or his, her or its attorney duly authorized in writing. The close of business on the date of receipt by the transfer agent (or by the Corporation if the Corporation serves as
its own transfer agent) of such certificates (or lost certificate affidavit and agreement) and notice shall be the time of conversion (the “Conversion Time”), and the shares of Common Stock issuable upon conversion of the shares
represented by such certificate shall be deemed to be outstanding of record as of such date. The Corporation shall, as soon as practicable after the Conversion Time, (i) issue and deliver to such holder of Series E Preferred Stock, or to his,
her or its nominees, a certificate or certificates for the number of full shares of Common Stock issuable upon such conversion in accordance with the provisions hereof and a certificate for the number (if any) of the shares of Series E Preferred
Stock represented by the surrendered certificate that were not converted into Common Stock, (ii) pay in cash such amount as provided in Subsection 4.2 in lieu of any fraction of a share of Common Stock otherwise issuable upon such
conversion and (iii) subject to applicable law, pay all accrued or declared but unpaid dividends on the shares of Series E Preferred Stock converted. 
  

  
 8 

 4.3.2 Reservation of Shares. The Corporation shall at all times when the Series E
Preferred Stock shall be outstanding, reserve and keep available out of its authorized but unissued capital stock, for the purpose of effecting the conversion of the Series E Preferred Stock, such number of its duly authorized shares of Common Stock
as shall from time to time be sufficient to effect the conversion of all outstanding Series E Preferred Stock; and if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient to effect the conversion of all
then outstanding shares of the Series E Preferred Stock, the Corporation shall take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock to such number of shares as shall be sufficient for such
purposes, including, without limitation, engaging in best efforts to obtain the requisite stockholder approval of any necessary amendment to the Certificate of Incorporation. Before taking any action which would cause an adjustment reducing the
Series E Conversion Price below the then par value of the shares of Common Stock issuable upon conversion of the Series E Preferred Stock, the Corporation will take any corporate action which may, in the opinion of its counsel, be necessary in order
that the Corporation may validly and legally issue fully paid and nonassessable shares of Common Stock at such adjusted Series E Conversion Price. 

  
 9 

 4.3.3 Effect of Conversion. All shares of Series E Preferred Stock which shall have been
surrendered for conversion as herein provided shall no longer be deemed to be outstanding and all rights with respect to such shares shall immediately cease and terminate at the Conversion Time, except only the right of the holders thereof to
receive shares of Common Stock in exchange therefor, to receive payment in lieu of any fraction of a share otherwise issuable upon such conversion as provided in Subsection 4.2 and to receive payment of any dividends accrued or declared but
unpaid thereon. Any shares of Series E Preferred Stock so converted shall be retired and cancelled and may not be reissued as shares of such series, and the Corporation may thereafter take such appropriate action (without the need for stockholder
action) as may be necessary to reduce the authorized number of shares of Series E Preferred Stock accordingly. 
 4.3.4 No Further
Adjustment. Upon any such conversion, no adjustment to the Series E Conversion Price shall be made for any declared but unpaid dividends on the Series E Preferred Stock surrendered for conversion or on the Common Stock delivered upon conversion.

 4.3.5 Taxes. The Corporation shall pay any and all issue and other similar taxes that may be payable in respect of any issuance or
delivery of shares of Common Stock upon conversion of shares of Series E Preferred Stock pursuant to this Section 4. The Corporation shall not, however, be required to pay any tax which may be payable in respect of any transfer involved
in the issuance and delivery of shares of Common Stock in a name other than that in which the shares of Series E Preferred Stock so converted were registered, and no such issuance or delivery shall be made unless and until the person or entity
requesting such issuance has paid to the Corporation the amount of any such tax or has established, to the satisfaction of the Corporation, that such tax has been paid. 

4.4 Adjustment for Stock Splits and Combinations. If the Corporation shall at any time or from time to time after the Series E Original
Issue Date effect a subdivision of the outstanding Common Stock, the Series E Conversion Price in effect immediately before that subdivision shall be proportionately decreased so that the number of shares of Common Stock issuable on conversion of
each share of such series shall be increased in proportion to such increase in the aggregate number of shares of Common Stock outstanding. If the Corporation shall at any time or from time to time after the Series E Original Issue Date combine the
outstanding shares of Common Stock, the Series E Conversion Price in effect immediately before the combination shall be proportionately increased so that the number of shares of Common Stock issuable on conversion of each share of such series shall
be decreased in proportion to such decrease in the aggregate number of shares of Common Stock outstanding. Any adjustment under this subsection shall become effective at the close of business on the date the subdivision or combination becomes
effective. 
 4.5 Adjustment for Certain Dividends and Distributions. In the event the Corporation at any time or from time to time
after the Series E Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable on the Common Stock in additional shares of Common Stock,
then and in each such 

  
 10 

 
event the Series E Conversion Price in effect immediately before such event shall be decreased as of the time of such issuance or, in the event such a record date shall have been fixed, as of the
close of business on such record date, by multiplying the Series E Conversion Price then in effect by a fraction: 
  

	 	(1)	the numerator of which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date, and 

 

	 	(2)	the denominator of which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date plus the number of shares
of Common Stock issuable in payment of such dividend or distribution. 

 Notwithstanding the foregoing, (a) if such record date shall
have been fixed and such dividend is not fully paid or if such distribution is not fully made on the date fixed therefor, the Series E Conversion Price shall be recomputed accordingly as of the close of business on such record date and thereafter
the Series E Conversion Price shall be adjusted pursuant to this subsection as of the time of actual payment of such dividends or distributions; and (b) no such adjustment shall be made if the holders of Series E Preferred Stock simultaneously
receive a dividend or other distribution of shares of Common Stock in a number equal to the number of shares of Common Stock as they would have received if all outstanding shares of Series E Preferred Stock had been converted into Common Stock on
the date of such event. 
 4.6 Adjustments for Other Dividends and Distributions. In the event the Corporation at any time or from
time to time after the Series E Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable in securities of the Corporation (other than
a distribution of shares of Common Stock in respect of outstanding shares of Common Stock) or in other property and the provisions of Subsection 1 do not apply to such dividend or distribution, then and in each such event the holders of
Series E Preferred Stock shall receive, simultaneously with the distribution to the holders of Common Stock, a dividend or other distribution of such securities or other property in an amount equal to the amount of such securities or other property
as they would have received if all outstanding shares of Series E Preferred Stock had been converted into Common Stock on the date of such event. 

4.7 Adjustment for Merger or Reorganization, etc. Subject to the provisions of Subsection 2.3, if there shall occur any
reorganization, recapitalization, reclassification, consolidation or merger involving the Corporation in which the Common Stock (but not the Series E Preferred Stock) is converted into or exchanged for securities, cash or other property (other than
a transaction covered by Subsections 4.5 or 4.6), then, following any such reorganization, recapitalization, reclassification, consolidation or merger, each share of Series E Preferred Stock shall thereafter be convertible in lieu of
the Common Stock into which it was convertible prior to 

  
 11 

 
such event into the kind and amount of securities, cash or other property which a holder of the number of shares of Common Stock of the Corporation issuable upon conversion of one share of Series
E Preferred Stock immediately prior to such reorganization, recapitalization, reclassification, consolidation or merger would have been entitled to receive pursuant to such transaction; and, in such case, appropriate adjustment (as determined in
good faith by the Board) shall be made in the application of the provisions in this Section 4 with respect to the rights and interests thereafter of the holders of the Series E Preferred Stock, to the end that the provisions set forth in
this Section 4 (including provisions with respect to changes in and other adjustments of the Series E Conversion Price) shall thereafter be applicable, as nearly as reasonably may be, in relation to any securities or other property
thereafter deliverable upon the conversion of the Series E Preferred Stock. 
 4.8 Certificate as to Adjustments. Upon the occurrence
of each adjustment or readjustment of the Series E Conversion Price pursuant to this Section 4, the Corporation at its expense shall, as promptly as reasonably practicable but in any event not later than 10 days thereafter, compute such
adjustment or readjustment in accordance with the terms hereof and furnish to each holder of Series E Preferred Stock a certificate setting forth such adjustment or readjustment (including the kind and amount of securities, cash or other property
into which the Series E Preferred Stock is convertible) and showing in detail the facts upon which such adjustment or readjustment is based. The Corporation shall, as promptly as reasonably practicable after the written request at any time of any
holder of Series E Preferred Stock (but in any event not later than 10 days thereafter), furnish or cause to be furnished to such holder a certificate setting forth (i) the Series E Conversion Price then in effect, and (ii) the number of
shares of Common Stock and the amount, if any, of other securities, cash or property which then would be received upon the conversion of Series E Preferred Stock. 

4.9 Notice of Record Date. In the event: 

(a) the Corporation shall take a record of the holders of its Common Stock (or other capital stock or securities at the time issuable upon
conversion of the Series E Preferred Stock) for the purpose of entitling or enabling them to receive any dividend or other distribution, or to receive any right to subscribe for or purchase any shares of capital stock of any class or any other
securities, or to receive any other security; or 
 (b) of any capital reorganization of the Corporation, any reclassification of the Common
Stock of the Corporation, or any consolidation or merger of the Corporation; or 
 (c) of the voluntary or involuntary dissolution,
liquidation or winding-up of the Corporation, 
 then, and in each such case, the Corporation will send or cause to
be sent to the holders of the Series E Preferred Stock a notice specifying, as the case may be, (i) the record date for such dividend, distribution or right, and the amount and character of such dividend, distribution or right, or (ii) the
effective date on which such reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation or winding-up is proposed to take place, and the time, if any is to be fixed, as of
which the holders of record of Common Stock (or such other capital stock or securities at the time issuable upon the conversion of the Series E Preferred Stock) shall be entitled to exchange their shares of Common Stock (or such other capital stock
or securities) for securities or other property deliverable upon such reorganization, reclassification, consolidation, merger, transfer, dissolution, liquidation or winding-up, and the amount per share and
character of such exchange applicable to the Series E Preferred Stock and the Common Stock. Such notice shall be sent at least 10 days prior to the record date or effective date for the event specified in such notice. 

  
 12 

 5. Redemption by Corporation. 

5.1 Redemption. Shares of Series E Preferred Stock may be redeemed by the Corporation out of funds lawfully available therefor at a
price equal to the Series E Original Issue Price per share, plus all accrued or declared but unpaid dividends thereon (the “5.1 Redemption Price”), at any time after the later of (i) November 9, 2014 and (ii) the date
that no shares of Series D Preferred Stock remain outstanding, if the closing sales price of the Common Stock for 20 or more trading days in a period of 30 consecutive trading days is equal to or greater than 400% of the Series E Conversion Price;
provided, that the Corporation provides written notice of such redemption to each holder of Series E Preferred Stock within 30 days of the end of such 30 consecutive trading day period (the “5.1 Redemption Notice”). The Corporation
shall send the 5.1 Redemption Notice to each holder of record of Series E Preferred Stock not less than 30 days prior to the date fixed by the Corporation for such redemption (the “5.1 Redemption Date”). The 5.1 Redemption Notice
shall state: 
 (a) the 5.1 Redemption Date and the 5.1 Redemption Price; 

(b) the date upon which the holder’s right to convert such shares terminates (as determined in accordance with Subsection 4.1);
and 
 (c) that the holder is to surrender to the Corporation, in the manner and at the place designated, his, her or its certificate or
certificates representing the shares of Series E Preferred Stock to be redeemed pursuant to this Section 5.1. 
 Notwithstanding anything to the
contrary set forth in this Section 5, the Corporation may not exercise its right of redemption pursuant to this Section 5.1 with respect to any shares of Series E Preferred Stock which the holder thereof may not convert into
Common Stock pursuant to Subsection 4.1 as a result of the beneficial ownership limitations set forth therein (each such share, a “Nonredeemable Series E Share” and collectively, the “Nonredeemable Series E
Shares”). 
 5.2 Alternative Redemption. In the event that the Corporation exercises its redemption rights under
Subsection 5.1 but is unable to redeem all of the shares of Series E Preferred Stock in accordance with the last sentence of Subsection 5.1, then the Corporation may redeem all or a portion of the Nonredeemable Series E Shares at a
price per Nonredeemable Series E Share equal to the greater of (a) the 20 consecutive trading day average closing price per share of the Common Stock ending on the trading day immediately prior to the 5.1 Redemption Date plus any dividends
accrued or declared but unpaid thereon and (b) the Series E Conversion Price plus any dividends accrued or declared but unpaid thereon (the “5.2 Redemption Price” and, together with the 5.1 Redemption Price, the
“Redemption Prices”); provided, that the Corporation provides written notice of such redemption to each holder of Series E Preferred Stock within 30 days following the 5.1 Redemption Date (the “5.2 Redemption
Notice” and, together with the 5.1 Redemption Notice, the “Redemption Notices”). The Corporation shall send the 5.2 Redemption Notice to each holder of record of Series E Preferred Stock not less than 30 days prior to the
date fixed by the Corporation for such redemption (the “5.2 Redemption Date” and, together with the 5.1 Redemption Date, the “Redemption Dates”). 

  
 13 

 The 5.2 Redemption Notice shall state: 

(a) the 5.2 Redemption Date and the 5.2 Redemption Price; 

(b) the number of Nonredeemable Series E Shares (as determined in accordance with Subsection 4.1); and 

(c) that the holder is to surrender to the Corporation, in the manner and at the place designated, his, her or its certificate or certificates
representing the Nonredeemable Series E Shares of Series E Preferred Stock to be redeemed pursuant to this Section 5.2. 
 5.3
Surrender of Certificates; Payment. On or before a Redemption Date, each holder of shares of Series E Preferred Stock to be redeemed on such Redemption Date, unless such holder has exercised his, her or its right to convert such shares as
provided in Subsection 4, shall surrender the certificate or certificates representing such shares (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement
reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate) to the Corporation, in the manner and at the
place designated in the notice from the Corporation, and thereupon the applicable Redemption Price for such shares shall be payable to the order of the person whose name appears on such certificate or certificates as the owner thereof. In the event
less than all of the shares of Series E Preferred Stock represented by a certificate are redeemed, a new certificate representing the unredeemed shares of Series E Preferred Stock shall promptly be issued to such holder. 

5.4 Rights Subsequent to Redemption. If a Redemption Notice shall have been duly given, and if on the applicable Redemption Date the
applicable Redemption Price payable upon redemption of the shares of Series E Preferred Stock to be redeemed on such Redemption Date is paid or tendered for payment or deposited with an independent payment agent so as to be available therefor in a
timely manner, then notwithstanding that the certificates evidencing any of the shares of Series E Preferred Stock so called for redemption on such Redemption Date shall not have been surrendered, dividends with respect to such shares of Series E
Preferred Stock shall cease to accrue after such Redemption Date and all rights with respect to such shares shall forthwith after such Redemption Date terminate, except only the right of the holders to receive the applicable Redemption Price without
interest upon surrender of their certificate or certificates therefor. 

  
 14 

 5.5 Redemption Approval. Notwithstanding anything to the contrary set forth in this
Section 5, no redemptions may be effected by the Corporation pursuant to Subsection 5.1 or Subsection 5.2 unless and until such redemption has been approved by a majority in number of the directors of the Corporation that are not affiliated
with any holder of the Series E Preferred Stock or the Warrants (as defined in the Series E Purchase Agreement) and were not elected as a director of the Corporation as a result of being nominated or submitted for consideration by any holder of the
Series E Preferred Stock or Warrants or any affiliate thereof. 
 6. Redeemed or Otherwise Acquired Shares. Any shares of Series E
Preferred Stock that are redeemed or otherwise acquired (including pursuant to Subsection 5.4) by the Corporation or any of its subsidiaries shall be automatically and immediately cancelled and retired and shall not be reissued, sold or
transferred. Neither the Corporation nor any of its subsidiaries may exercise any voting or other rights granted to the holders of Series E Preferred Stock following redemption. 

7. Waiver. Any of the rights, powers, preferences and other terms of the Series E Preferred Stock set forth herein may be waived on
behalf of all holders of Series E Preferred Stock by the affirmative written consent or vote of the holders of at least a majority of the then outstanding Series E Preferred Stock. 

8. Notices. Any notice required or permitted to be given to a holder of shares of Series E Preferred Stock shall be mailed, postage
prepaid, to the post office address last shown on the records of the Corporation, or given by electronic communication in compliance with the provisions of the General Corporation Law, and shall be deemed sent upon such mailing or electronic
transmission. 
 IN WITNESS WHEREOF, this Certificate of Designations has been executed by a duly authorized officer of this
corporation on this 9th day of November, 2012. 
  

			
	By:	 	/s/ Sudhir Agrawal
		 	Chief Executive Officer

  
 15 

 IDERA PHARMACEUTICALS, INC. 

CERTIFICATE OF ELIMINATION 

OF NUMBER OF SHARES OF PREFERRED STOCK DESIGNATED AS SERIES C 

JUNIOR PARTICIPATING PREFERRED STOCK PREFERRED STOCK 

Idera Pharmaceuticals, Inc. (hereinafter called the “Corporation”), pursuant to the authority conferred upon the Board of Directors
of the Corporation (the “Board”) by the Corporation’s Restated Certificate of Incorporation, as amended (the “Certificate of Incorporation”), and in accordance with the provisions of Section 151(g) of the General Corporation
Law of the State of Delaware (the “Delaware Law”), certifies that the Board duly adopted the following resolution: 
  

			
	“RESOLVED:	  	That no shares of the Corporation’s Series C Junior Participating Preferred Stock (the “Series C Preferred Stock”) are outstanding and no shares of Series C Preferred Stock will be issued subject to the Certificate of
Designation, Preferences and Rights of Series C Preferred Stock, dated December 10, 2001, as amended, with respect to such series (the “Series C Certificate of Designation”); and that the Proper Officers be and hereby are authorized and
directed in the name and on behalf of the Corporation to execute and file a certificate with the Secretary of State of the State of Delaware pursuant to Section 151(g) of the Delaware Law setting forth the text of this resolution, upon the filing
and effectiveness of which all matters as set forth in the Series C Certificate of Designation shall be deemed to have been eliminated from the Restated Certificate and the 200,000 shares of Preferred Stock previously designated as Series C
Preferred Stock shall resume their status as undesignated shares of Preferred Stock available for future issuance in accordance with the Restated Certificate.”

 IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its duly
authorized officer this 17th day of June, 2013. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Sudhir Agrawal

		 	Sudhir Agrawal, D. Phil.
		 	Chairman of the Board of Directors,
		 	President and Chief Executive Officer

 IDERA PHARMACEUTICALS, INC. 

CERTIFICATE OF AMENDMENT OF 

CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF 

SERIES D PREFERRED STOCK 
  

 
 Pursuant to
Section 242 of the 
 General Corporation Law of the State of Delaware 

 
  

Idera Pharmaceuticals, Inc., a Delaware corporation (the “Corporation”), in accordance with Section 103 of the General
Corporation Law of the State of Delaware (the “General Corporation Law”), hereby certifies as follows: 
 A Certificate of
Designations, Preferences and Rights of Series D Preferred Stock (the “Certificate of Designations”) was filed with the Secretary of State of the State of Delaware on November 4, 2011 pursuant to Section 151 of the General
Corporation Law. By action of the Board of Directors of the Corporation, the Board of Directors of the Corporation duly adopted resolutions, pursuant to Section 242 of the General Corporation Law, setting forth amendments to the Certificate of
Designations and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendments in accordance with Section 242 of the General Corporation Law at a meeting of stockholders held on
July 26, 2013. The resolutions setting forth the proposed amendment are as follows: 
 RESOLVED, that Section 1.1 of the
Certificate of Designations be deleted in its entirety and that the following paragraph be inserted in lieu thereof: 

“1.1 Series D Preferred Dividends. 

1.1.1 Each holder of Series D Preferred Stock shall be entitled to receive, with respect to each share of Series D Preferred
Stock then outstanding and held by such holder of Series D Preferred Stock, dividends, commencing from the date of issuance of such share of Series D Preferred Stock, at the rate of seven percent (7%) per annum (on the basis of a 360 day year)
of the Series D Original Issue Price (as defined below) (the “Series D Preferred Dividends”). The Series D Preferred Dividends shall be cumulative, whether or not earned or declared, shall be paid quarterly in arrears on the last
day of December, March, June and September (a “Quarterly Dividend Payment Date”) in each year that Series D Preferred Stock is outstanding, with the first Quarterly Dividend Payment Date being December 31, 2011, and shall be
prorated for periods shorter than one quarter. The rights of a holder of Series D Preferred Stock as Series D Preferred Dividends shall rank senior to the rights of the Corporation’s Series A Convertible Preferred Stock as to dividends. 

1.1.2 The Series D Preferred Dividends shall be paid to each holder of Series D Preferred Stock in cash out of legally
available funds or, at the Corporation’s election, through the issuance of such number of shares of the Corporation’s Common 

 
Stock, par value $0.001 per share (the “Common Stock”) (rounded down to the nearest whole share with any fractional shares being issued in cash in an amount equal to the Market
Price (as defined in Section 4.2 below) of such fractional share of Common Stock) determined by dividing the amount of the total accrued but unpaid dividends then outstanding on such holder’s shares of Series D Preferred Stock by the
Market Price then in effect (which for this purpose may not be less than $1.46 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Common
Stock); provided, however, that (i) the Corporation may not pay such dividends in shares of Common Stock on or prior to October 1, 2013, (ii) the Corporation may not issue shares of Common Stock in excess of that number
of shares of Common Stock which, upon giving effect to such issuance, would cause (a) the aggregate number of shares of Common Stock beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose
beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), to exceed 19.99% of the total number of
issued and outstanding shares of Common Stock of the Corporation following such issuance, or (b) the combined voting power of the securities of the Corporation beneficially owned by a holder of Series D Preferred Stock and its affiliates and
any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined voting power of all of the securities of the Corporation
then outstanding following such issuance, unless and until, in either case of clause (a) and clause (b) of this Section 1.1.2, the stockholders of the Corporation approve the Nasdaq Proposal (as defined by and in accordance with
Section 5.11(B) of that certain Convertible Preferred Stock and Warrant Purchase Agreement, dated November 9, 2012, between the Corporation and the Purchasers named therein), in which case, the 19.99% limitation under clause (a) and
(b) of this Section 1.1.2 shall be increased, with respect to any holder of Series D Preferred Stock, to 35% for purposes of both clause (a) and clause (b) of this Section 1.1.2, and (iii) if clause (ii) shall in
fact limit the issuance of any shares of Common Stock in payment of a given dividend, then the Corporation’s election to pay such dividend in shares of Common Stock shall be ineffective to the extent of such limitation and such dividend shall
instead thereupon be paid, at the Corporation’s election, (x) in cash by the Corporation out of legally available funds or (y) through the issuance of a number of shares of the Corporation’s Series F Convertible Preferred Stock,
par value $0.01 per share (the “Series F Preferred Stock”) equal to one-twentieth (1/20th) of the number of shares of Common Stock that the Corporation could have issued
pursuant to this Section 1.1.2 with respect to such Series D Preferred Dividends but for the limitations set forth in clause (a) and clause (b) of this Section 1.1.2. 

1.1.3 Any election by the Corporation to pay Series D Preferred Dividends in cash or in shares of Common Stock or Series F
Preferred Stock shall be made uniformly with respect to all outstanding shares of Series D Preferred Stock for a given dividend period. 

1.1.4 For purposes of this Section 1.1 the aggregate number of shares of Common Stock or voting securities beneficially
owned by a holder of Series D Preferred 

  
 - 2 - 

 
Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act, shall
include the shares of Common Stock to be issued as part of such dividend payment, but shall exclude the number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or non-cancelled portion
of any other securities of the Corporation that do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire at any time Common Stock, including without limitation any
debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock), subject to a limitation on conversion or
exercise analogous to the limitation contained herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of
Section 13(d) of the Exchange Act.” 

*            *           
 * 
 RESOLVED, that Section 1.3 of the Certificate of Designations be deleted in its entirety and that the following
paragraph be inserted in lieu thereof: 
 “1.3 The Corporation shall not declare, pay or set aside any dividends on
shares of any other class or series of capital stock of the Corporation (other than dividends on shares of Common Stock payable in shares of Common Stock, dividends on the Series A Convertible Preferred Stock in accordance with Section 2(a) of
the Certificate of Designations for the Series A Convertible Preferred Stock and dividends on the Series E Preferred Stock in accordance with Section 1.1 of the Certificate of Designations for the Series E Convertible Preferred Stock unless the
holders of the Series D Preferred Stock then outstanding shall first receive, or simultaneously receive, a dividend on each outstanding share of Series D Preferred Stock in an amount at least equal to the sum of (i) the amount of the aggregate
dividends then accrued on such share of Series D Preferred Stock and not previously paid and (ii) (A) in the case of a dividend on Common Stock or any class or series that is convertible into Common Stock, that dividend per share of Series
D Preferred Stock as would equal the product of (1) the dividend payable on each share of such class or series determined, if applicable, as if all shares of such class or series had been converted into Common Stock and (2) the number of
shares of Common Stock issuable upon conversion of a share of Series D Preferred Stock, in each case calculated on the record date for determination of holders entitled to receive such dividend or (B) in the case of a dividend on any class or
series that is not convertible into Common Stock, at a rate per share of Series D Preferred Stock determined by (1) dividing the amount of the dividend payable on each share of such class or series of capital stock by the original issuance
price of such class or series of capital stock (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (2) multiplying such
fraction by an amount equal to the Series D Original Issue Price; provided that, if the Corporation declares, pays or sets aside, on the same date, a dividend on shares of more than one class or series of capital stock of the Corporation, the
dividend payable to the holders of Series D Preferred Stock pursuant to this Section 1.3 shall be calculated based upon the dividend on the class or series of capital stock that would result in the highest Series D Preferred Stock
dividend.” 

*            *           
 * 

  
 - 3 - 

 RESOLVED, that Section 2.1 of the Certificate of Designations be deleted in its
entirety and that the following paragraph be inserted in lieu thereof: 
 “2.1 Payments to Holders of Series D
Preferred Stock. In the event of any voluntary or involuntary liquidation, dissolution or winding up of the Corporation, the holders of shares of Series D Preferred Stock then outstanding shall be entitled to be paid out of the assets of the
Corporation available for distribution to its stockholders before any payment shall be made to the holders of Common Stock, Series A Convertible Preferred Stock or any other class of capital stock of the Corporation ranking junior to the Series D
Preferred Stock as to liquidation, by reason of their ownership thereof, an amount per share equal to such amount as would have been payable with respect to such share had all shares of Series D Preferred Stock been converted into Common Stock
pursuant to Section 4 immediately prior to such liquidation, dissolution or winding up, disregarding for these purposes the limitations on conversion due to beneficial ownership set forth in Subsection 4.1.1. If upon any such
liquidation, dissolution or winding up of the Corporation, the assets of the Corporation available for distribution to its stockholders shall be insufficient to pay the holders of shares of Series D Preferred Stock the full amount to which they
shall be entitled under this Subsection 2.1, the holders of shares of Series D Preferred Stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be
payable in respect of the shares held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full.” 

*            *           
 * 
 RESOLVED, that Section 4.1.1 of the Certificate of Designations be deleted in its entirety and that the following
paragraph be inserted in lieu thereof: 
 “4.1.1 Conversion Ratio. Each share of Series D Preferred Stock shall
be convertible, at the option of the holder thereof, at any time and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is
determined by dividing the Series D Original Issue Price by the Series D Conversion Price (as defined below) in effect at the time of conversion. The “Series D Conversion Price” shall initially be equal to $1.6275. Such initial Series D
Conversion Price, and the rate at which shares of Series D Preferred Stock may be converted into shares of Common Stock, shall be subject to adjustment as provided below. Notwithstanding the foregoing, the Corporation shall not effect any conversion
of such holder’s Series D Preferred Stock and such holder shall not be entitled to convert its shares of Series D Preferred Stock for a number of shares of Common Stock in excess of that number of shares of Common Stock which, upon giving
effect to such conversion, would cause (a) the aggregate number of shares of Common Stock beneficially owned by a holder of Series D Preferred Stock and its affiliates and 

  
 - 4 - 

 
any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the total number
of issued and outstanding shares of Common Stock of the Corporation (including for such purpose the shares of Common Stock issuable upon conversion of the Series D Preferred Stock) following such conversion, or (b) the combined voting power of
the securities of the Corporation beneficially owned by a holder of Series D Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of
Section 13(d) of the Exchange Act to exceed 19.99% of the combined voting power of all of the securities of the Corporation then outstanding following such conversion, unless, in either case, the stockholders of the Corporation approve the
Nasdaq Proposal, in which case, the 19.99% limitation under clause (a) and clause (b) of this Section 4.1.1 shall be increased, with respect to any holder of Series D Preferred Stock, to 35% for purposes of both clause (a) and
clause (b) of this Section 4.1.1. For purposes of this Section 4.1.1, the aggregate number of shares of Common Stock or voting securities beneficially owned by the holder and its affiliates and any other persons whose beneficial
ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act shall include the shares of Common Stock issuable upon the conversion of the Series D Preferred Stock with respect to which
such determination is being made, but shall exclude the number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or non-cancelled portion of any other securities of the Corporation that
do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire at any time Common Stock, including without limitation any debt, preferred stock, right, option, warrant or
other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock), subject to a limitation on conversion or exercise analogous to the limitation contained
herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act.” 

*            *           
 * 
 RESOLVED, that Section 4.1.2 of the Certificate of Designations be deleted in its entirety and that the following
paragraph be inserted in lieu thereof: 
 “4.1.2 Termination of Conversion Rights. In the event of a notice of
redemption of any shares of Series D Preferred Stock pursuant to Section 5, the Conversion Rights of the shares designated for redemption shall terminate at the close of business on the last full day preceding the date fixed for redemption,
unless the redemption price is not fully paid on such redemption date, in which case the Conversion Rights for such shares shall continue until such price is paid in full. In the event of a liquidation, dissolution or winding up of the Corporation
or a Sale of the Corporation (as defined in Section 6.2 below), the Conversion Rights shall terminate at the close of business on the last full day preceding the date fixed for the payment of any such amounts distributable on such event to the
holders of Series D Preferred Stock.” 

*            *           
 * 

  
 - 5 - 

 RESOLVED, that Section 6 of the Certificate of Designations be deleted in its
entirety and that the following paragraph be inserted in lieu thereof: 
 “6. Sale of the Corporation. 

6.1 In the event of a Sale of the Corporation (as defined below) after payment shall be made to the holders of Series A
Convertible Preferred Stock and any other class of capital stock of the Corporation ranking senior to the Series D Preferred Stock upon a Sale of the Corporation, the remaining assets of the Corporation available for distribution to its stockholders
shall be distributed among the holders of the shares of Series D Preferred Stock, Series E Preferred Stock and Common Stock pro rata based on the number of shares held by each such holder, treating for this purpose all such securities as if they had
been converted to Common Stock pursuant to the terms of the Certificate of Incorporation immediately prior to such Sale of the Corporation disregarding for these purposes the limitations on conversion due to beneficial ownership set forth in
Subsection 4.1.1. 
 6.2 The term “Sale of the Corporation” shall mean each of the following events:
(a) a merger or consolidation in which (i) the Corporation is a constituent party or (ii) a subsidiary of the Corporation is a constituent party and the Corporation issues shares of its capital stock pursuant to such merger or
consolidation (except in the case of clause (i) and (ii), any such merger or consolidation involving the Corporation or a subsidiary in which the shares of capital stock of the Corporation outstanding immediately prior to such merger or
consolidation continue to represent, or are converted into or exchanged for shares of capital stock that represent, immediately following such merger or consolidation, at least a majority, by voting power, of the capital stock of (y) the
surviving or resulting corporation or (z) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or resulting
corporation; or (b) the sale, lease, transfer, exclusive license or other disposition, in a single transaction or series of related transactions, by the Corporation or any subsidiary of the Corporation of all or substantially all the assets of
the Corporation and its subsidiaries taken as a whole, or the sale or disposition (whether by merger or otherwise) of one or more subsidiaries of the Corporation if substantially all of the assets of the Corporation and its subsidiaries taken as a
whole are held by such subsidiary or subsidiaries, except where such sale, lease, transfer, exclusive license or other disposition is to a wholly owned subsidiary of the Corporation. For the purposes of clarity, a Sale of the Corporation shall not
be deemed to be a liquidation, dissolution or winding up of the Corporation for the purposes of this Section 6.” 

*            *           
 * 

  
 - 6 - 

 IN WITNESS WHEREOF, this Certificate of Amendment has been executed by a duly authorized officer
of the Corporation on this 26th day of July, 2013. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Sudhir Agrawal

	Name:	 	Sudhir Agrawal
	Title:	 	Chief Executive Officer

  
 - 7 - 

 IDERA PHARMACEUTICALS, INC. 

CERTIFICATE OF AMENDMENT OF 

CERTIFICATE OF DESIGNATIONS, PREFERENCES AND RIGHTS OF 

SERIES E PREFERRED STOCK 
  

 
 Pursuant to
Section 242 of the 
 General Corporation Law of the State of Delaware 

 
  

Idera Pharmaceuticals, Inc., a Delaware corporation (the “Corporation”), in accordance with Section 103 of the General
Corporation Law of the State of Delaware (the “General Corporation Law”), hereby certifies as follows: 
 A Certificate of
Designations, Preferences and Rights of Series E Preferred Stock (the “Certificate of Designations”) was filed with the Secretary of State of the State of Delaware on November 9, 2012 pursuant to Section 151 of the General
Corporation Law. By action of the Board of Directors of the Corporation, the Board of Directors of the Corporation duly adopted resolutions, pursuant to Section 242 of the General Corporation Law, setting forth amendments to the Certificate of
Designations and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendments in accordance with Section 242 of the General Corporation Law at a meeting of stockholders held on
July 26, 2013. The resolutions setting forth the proposed amendment are as follows: 
 RESOLVED, that Section 1.1 of the
Certificate of Designations be deleted in its entirety and the following new paragraph be inserted in lieu thereof: 
 “1.1 Series E
Preferred Dividends. 
 1.1.1 Each holder of Series E Preferred Stock shall be entitled to receive with respect to each share of Series E
Preferred Stock then outstanding and held by such holder of Series E Preferred Stock, dividends, commencing from the date of issuance of such share of Series E Preferred Stock, at the Initial Dividend Rate (as defined below) per annum (on the basis
of a 360 day year) of the Series E Original Issue Price (as defined below) (the “Series E Preferred Dividends”); provided, however, that subject to and effective upon the filing with the Delaware Secretary of State of the amendment
to the Certificate of Designations, Preferences and Rights of Series D Preferred Stock (the “Series D Certificate of Designations,” with the amendment thereto being referred to as the “Amendment to Series D Certificate of
Designations”) as described in Section 5.11(B) of that certain Convertible Preferred Stock and Warrant Purchase Agreement, dated November 9, 2012, between the Corporation and the purchasers of the Series E Preferred Stock therein
(the “Series E Purchase Agreement”), the dividend rate provided for in this Section 1.1 shall be increased from the Initial Dividend Rate to the rate of eight percent (8%) per annum (on the basis of a 360 day year) of the
Series E Original Issue Price. The Series E Preferred Dividends shall be cumulative, whether or not earned or declared, shall be paid quarterly in arrears on the last day of March, June, September and December (a “Quarterly Dividend Payment
Date”) in each year that Series E Preferred Stock is outstanding, with the first Quarterly Dividend Payment Date being March 31, 2013, and shall 

 
be prorated for periods shorter than one quarter. Notwithstanding the foregoing, if, as of any Quarterly Dividend Payment Date at which the dividend rate is the Initial Dividend Rate, there are
no shares of the Corporation’s Series D Convertible Preferred Stock outstanding, then the dividend payable on such Quarterly Dividend Payment Date shall be calculated and paid at a rate of eight percent (8%) per annum (on the basis of a
360 day year) of the Series E Original Issue Price. In the event that the Amendment to Series D Certificate of Designations is filed with the Delaware Secretary of State and the dividend rate with respect to the Series E Preferred Dividends is
increased pursuant to this Section 1.1.1, the Series E Preferred Dividends paid on the first Quarterly Dividend Payment Date after such filing and increase shall be paid at the increased rate. In the event that the Amendment to Series D
Certificate of Designations is submitted to the stockholders of the Corporation as contemplated by Section 5.11 of the Series E Purchase Agreement and the Amendment to Series D Certificate of Designations is not approved, then the holders of
the Series E Preferred Stock shall no longer be entitled to any Series E Preferred Dividends under this Section 1.1.1 and the Corporation shall have no further obligation to pay the Series E Preferred Dividends under this Section 1.1.1;
provided, however, the Corporation shall not submit the Amendment to the Series D Certificate of Designations to the stockholders if there are no shares of Series D Preferred Stock then outstanding. The rights of a holder of Series E Preferred Stock
to Series E Preferred Dividends shall rank senior to the rights of the Corporation’s Series A Convertible Preferred Stock and Series D Convertible Preferred Stock as to dividends. The term “Initial Dividend Rate” shall mean
four and six tenths percent (4.6%) or such other percentage approved by the Corporation and by the holders of at least a majority of then outstanding shares of Series E Preferred Stock, with such approval given in writing or by vote at a
meeting, consenting or voting (as the case may be) as a separate class. 
 1.1.2 The Series E Preferred Dividends shall be paid to each
holder of Series E Preferred Stock in cash out of legally available funds or, at the Corporation’s election, through the issuance of such number of shares of Common Stock (as defined in Section 1.3 below) (rounded down to the nearest whole
share with any fractional shares being issued in cash in an amount equal to the Market Price (as defined in Section 4.2 below) of such fractional share of Common Stock) determined by dividing the amount of the total accrued but unpaid dividends
then outstanding on such holder’s shares of Series E Preferred Stock by the Market Price then in effect (which for this purpose may not be less than $0.70 per share, subject to appropriate adjustment in the event of any stock dividend, stock
split, combination or other similar recapitalization with respect to the Common Stock); provided, however, that (i) the Corporation may not pay such dividends in shares of Common Stock on or prior to October 1, 2013,
(ii) the Corporation may not issue shares of Common Stock in excess of that number of shares of Common Stock which, upon giving effect to such issuance, would cause (a) the aggregate number of shares of Common Stock beneficially owned by a
holder of Series E Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act (as defined in
Section 4.1.2), to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Corporation following such issuance, or (b) the combined voting power of the securities of the Corporation beneficially owned by a
holder of Series E Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined
voting power of all of the securities of the Corporation then outstanding 

  
 - 2 - 

 
following such issuance, unless and until, in either case of clause (a) and clause (b) of this Section 1.1.2, the stockholders of the Corporation approve the Nasdaq Proposal (as
defined in Section 3.1 below), in which case, the 19.99% limitation under clause (a) and (b) of this Section 1.1.2 shall be increased, with respect to any holder of Series E Preferred Stock, to 35% for purposes of both clause
(a) and clause (b) of this Section 1.1.2, and (iii) if clause (ii) shall in fact limit the issuance of any shares of Common Stock in payment of a given dividend, then the Corporation’s election to pay such dividend in
shares of Common Stock shall be ineffective to the extent of such limitation and such dividend shall instead thereupon be paid, at the Corporation’s election, (x) in cash by the Corporation out of legally available funds or
(y) through the issuance of a number of shares of the Corporation’s Series F Convertible Preferred Stock, par value $0.01 per share (the “Series F Preferred Stock”) equal to one-twentieth (1/20th) of the number of shares of Common Stock that the Corporation could have issued pursuant to this Section 1.1.2 with respect to such Series E Preferred Dividends but for the limitations set
forth in clause (a) and clause (b) of this Section 1.1.2. 
 1.1.3 Any election by the Corporation to pay Series E Preferred
Dividends in cash or shares of Common Stock and/or Series F Preferred Stock shall be made uniformly with respect to all outstanding shares of Series E Preferred Stock for a given dividend period. 

1.1.4 For purposes of this Section 1.1, the aggregate number of shares of Common Stock or voting securities beneficially owned by a
holder of Series E Preferred Stock and its affiliates and any other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange Act, shall include the shares of
Common Stock to be issued as part of such dividend payment, but shall exclude the number of shares of Common Stock which would be issuable upon exercise or conversion of the unexercised, non-converted or non-cancelled portion of any other securities
of the Corporation that do not have voting power (including without limitation any securities of the Corporation which would entitle the holder thereof to acquire at any time Common Stock, including without limitation any debt, preferred stock,
right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock), subject to a limitation on conversion or exercise analogous to
the limitation contained herein beneficially owned by the holder or any of its affiliates and other persons whose beneficial ownership of Common Stock would be aggregated with the holder’s for purposes of Section 13(d) of the Exchange
Act.” 

*            *           
 * 
 RESOLVED, that Section 2.1.1 of the Certificate of Designations be deleted in its entirety and that the following
paragraph be inserted in lieu thereof: 
 “2.1.1 In the event of any voluntary or involuntary liquidation, dissolution or winding up of
the Corporation, the holders of shares of Series E Preferred Stock then outstanding shall be entitled to be paid out of the assets of the Corporation available for distribution to its stockholders before any payment shall be made to the holders of
Common Stock, Series A Convertible Preferred Stock, Series D Convertible Preferred Stock or any other class of capital stock of the Corporation ranking junior to the Series E Preferred Stock as to liquidation, by reason of their ownership thereof,
an amount per share equal to such amount as would have been 

  
 - 3 - 

 
payable with respect to such share had all shares of Series E Preferred Stock been converted into Common Stock pursuant to Subsection 4 immediately prior to such liquidation, dissolution
or winding up disregarding for these purposes the limitations on conversion due to beneficial ownership set forth in Subsection 4.1.2.” 

*            *           
 * 
 RESOLVED, that Section 2.3.1 of the Certificate of Designations be deleted in its entirety and that the following
paragraph be inserted in lieu thereof: 
 “2.3.1 In the event of a Sale of the Corporation (as defined below) after payment shall be
made to the holders of Series A Convertible Preferred Stock and any other class of capital stock of the Corporation ranking senior to the Series E Preferred Stock upon a Sale of the Corporation, the remaining assets of the Corporation available for
distribution to its stockholders shall be distributed among the holders of the shares of Series E Preferred Stock, Series D Preferred Stock and Common Stock pro rata based on the number of shares held by each such holder, treating for this purpose
all such securities as if they had been converted to Common Stock pursuant to the terms of the Certificate of Incorporation immediately prior to such Sale of the Corporation disregarding for these purposes the limitations on conversion due to
beneficial ownership set forth in Subsection 4.1.2.” 

*            *           
 * 
 IN WITNESS WHEREOF, this Certificate of Amendment has been executed by a duly authorized officer of the Corporation on this 26th
day of July, 2013. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Sudhir Agrawal

	Name:	 	Sudhir Agrawal
	Title:	 	Chief Executive Officer

  
 - 4 - 

 CERTIFICATE OF AMENDMENT 

TO THE 
 RESTATED
CERTIFICATE OF INCORPORATION 
 OF 

IDERA PHARMACEUTICALS, INC. 

Idera Pharmaceuticals, Inc. (hereinafter called the “Corporation”), organized and existing under and by virtue of the General
Corporation Law of the State of Delaware, does hereby certify as follows: 
 By action of the Board of Directors of the Corporation at a
meeting held on May 22, 2013, the Board of Directors of the Corporation duly adopted a resolution, pursuant to Section 242 of the General Corporation Law of the State of Delaware, setting forth an amendment to the Restated Certificate of
Incorporation of the Corporation, as amended to date (the “Certificate of Incorporation”), and declaring said amendment to be advisable. The stockholders of the Corporation duly approved said proposed amendment in accordance with
Section 242 of the General Corporation Law of the State of Delaware at a meeting of stockholders held on July 26, 2013. The resolution setting forth the amendment is as follows: 

RESOLVED: That the first paragraph of Article FOURTH of the Certificate of Incorporation be and hereby is amended and restated in
its entirety so that the same shall read as follows: 
 “FOURTH. The total number of shares of all classes of stock which the
Corporation shall have authority to issue is (i) Two Hundred Eighty Million (280,000,000) shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) Five Million (5,000,000) shares of Preferred
Stock, $.01 par value per share (“Preferred Stock”), which may be issued from time to time in one or more series as set forth in Part B of this Article FOURTH.” 

IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment to be signed by its duly authorized officer this 26th day of
July, 2013. 
  

			
	IDERA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Sudhir Agrawal

		 	Sudhir Agrawal, D. Phil.
		 	President and Chief Executive OfficerEX-10.1

 Exhibit 10.1 

AMENDMENT NO. 2 TO CREDIT AGREEMENT 

AMENDMENT NO. 2 TO CREDIT AGREEMENT (this “Amendment”), dated as of January 30, 2014, is made with respect to the Credit
Agreement dated as of September 23, 2011, (as amended, restated, supplemented or otherwise modified prior to the date hereof, the “Credit Agreement”), among McKesson Corporation (the “Company”), McKesson Canada
Corporation (together with the Company, the “Borrowers”), the lenders from time to time party thereto, Bank of America, N.A., as administrative agent (the “Administrative Agent”), and Bank of America, N.A., as
Canadian Administrative Agent (the “Canadian Administrative Agent”). 
 The parties hereto agree as follows: 

Defined Terms. Capitalized terms used but not defined herein shall have the meanings given to them in the Credit Agreement. 

Amendment. 

Section 1.01 of the Credit Agreement is hereby amended by: 

amending and restating the definition of “Celesio Acquisition Closing Date” in its entirety as follows: 

“Celesio Acquisition Closing Date” means the date on which Celesio first becomes a Subsidiary of the Borrower pursuant to the
private sale, convertible bond purchase and tender offer contemplated by the Share Purchase Agreement, dated as of January 23, 2014, among the Borrower, Bidco and Franz Haniel & Cie. GmbH and the Sale and Purchase Agreement relating to
the convertible bonds issued by Celesio dated as of January 23, 2014, among the Borrower, Bidco, Elliott International, L.P., The Liverpool Limited Partnership and Elliott Capital Advisors, L.P. 

replacing “October 23, 2013” with “January 23, 2014” in the definition of “Celesio Bridge
Facility”; and 
 replacing “October 23, 2013” with “January 23, 2014” in the definition of
“Celesio Bridge Effective Date”. 
 Section 7.04 of the Credit Agreement is hereby amended by replacing “October 23,
2013” with “January 23, 2014”. 
 Representations and Warranties. Each Borrower represents and warrants that: 

the representations and warranties of such Borrower contained in Article V of the Credit Agreement shall be true and correct on and as of the
Amendment Effective Date (as defined below), except to the extent that such representations and warranties specifically refer to an earlier date, in which case they shall be true and correct as of such earlier date, and except that for purposes of
this Section 3 of this Amendment, the representations and warranties contained in Section 5.08(a) of the Credit Agreement shall be deemed to refer to the most recent financial statements furnished pursuant to Section 6.01(a) and
Section 6.01(b) of the Credit Agreement, respectively; and 

 after giving effect to this Amendment, no event has occurred and is continuing or will result
from the consummation of the transactions contemplated by this Amendment that would constitute an Event of Default or a Default. 

Effectiveness. This Amendment shall become effective on the date (the “Amendment Effective Date”) on which each of the
following conditions shall be satisfied: 
 The Administrative Agent shall have received from each Borrower, the Canadian Administrative
Agent and the Lenders party hereto, who constitute the Required Lenders, either (i) a counterpart of this Amendment signed on behalf of such party or (ii) evidence satisfactory to the Administrative Agent that such party has signed a
counterpart of this Amendment; 
 The Administrative Agent shall have received a certificate signed by a Responsible Officer of the Company
certifying that the representations and warranties contained in Section 3 of this Amendment are true and correct; and 
 The Borrower
shall have paid all expenses of the Administrative Agent payable pursuant to Section 11.04(a) of the Credit Agreement to the extent invoiced on or prior the Amendment Effective Date (including, without limitation, the reasonable fees and
disbursements of counsel to the Administrative Agent). 
 Reference to and Effect Upon the Credit Agreement. 

Except as expressly set forth herein, this Amendment shall not by implication or otherwise limit, impair, constitute a waiver of, or otherwise
affect the rights and remedies of the Lenders, the Administrative Agent, the Canadian Administrative Agentor any other party under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in any way affect any of the
terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect. 

Nothing herein shall be deemed to entitle any Loan Party to a consent to, or a waiver, amendment, modification or other change of, any of the
terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document in similar or different circumstances. 

On and as of the Amendment Effective Date, each reference in the Credit Agreement to “this Agreement”, “hereof”,
“hereunder”, “herein” and “hereby” and each other similar reference, and each reference in any other Loan Document to “the Credit Agreement”, “thereof”, “thereunder”, “therein” or
“thereby” or any other similar reference to the Credit Agreement shall refer to the Credit Agreement as amended hereby. 
 Loan
Document. This Amendment is a “Loan Document” under the Credit Agreement. 
 Governing Law. This Amendment shall be
construed in accordance with and governed by the laws of the State of New York. 
 Counterparts. This Amendment may be signed in any
number of counterparts by each of the Borrower, the Administrative Agent, and the Lenders party hereto, each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument. Delivery of an
executed counterpart hereof by facsimile or electronic transmission (e.g., “pdf” or “tif”) shall be as effective as delivery of a manually executed counterpart hereof. 

[Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date first above
written. 
  

			
	MCKESSON CORPORATION
		
	By:	 	  /s/ Nicholas A. Loiacono

		 	Name: Nicholas A. Loiacono
		 	Title:   Vice President and Treasurer

 
			
	BANK OF AMERICA, N.A., as Administrative Agent
		
	By:	 	 /s/ Joan Mok

		 	Name: Joan Mok
		 	Title:   Vice President
	
	BANK OF AMERICA, N.A. (acting through its Canada Branch), as Canadian Administrative Agent
		
	By:	 	 /s/ Medina Sales de Andrade

		 	Name: Medina Sales de Andrade
		 	Title:   Vice President
	
	BANK OF AMERICA, N.A., as Lender
		
	By:	 	 /s/ Zubin R. Shroff

		 	Name: Zubin R. Shroff
		 	Title:   Director
	
	BANK OF AMERICA, N.A. (acting through its Canada Branch), as Canadian Lender
		
	By:	 	 /s/ Medina Sales de Andrade

		 	Name: Medina Sales de Andrade
		 	Title:   Vice President

 
			
	 Wells Fargo Bank National Association

		
	By:	 	 /s/ Kirk Tesch

		 	Name: Kirk Tesch
		 	Title:   Director

 
			
	JPMORGAN CHASE BANK, N.A.
		
	By:	 	 /s/ Vanessa Chiu

		 	Name: Vanessa Chiu
		 	Title:   Executive Director

 
			
	The Bank of Tokyo-Mitsubishi UFJ, Ltd.
		
	By:	 	 /s/ Jaime Sussman

		 	Name: Jaime Sussman
		 	Title:   VP

 
			
	THE BANK OF NOVA SCOTIA
		
	By:	 	 /s/ Eugene Dempsey

		 	Name: Eugene Dempsey
		 	Title:   Director

 
			
	U.S. BANK NATIONAL ASSOCIATION
		
	By:	 	 /s/ Joyce P. Dorsett

		 	Name: Joyce P. Dorsett
		 	Title:   Vice President

 
			
	COÖPERATIEVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A., “RABOBANK NEDERLAND”, NEW YORK BRANCH, as Lender
		
	By:	 	 /s/ Deborah Dias

		 	Name: Deborah Dias
		 	Title:   Executive Director
		
	By:	 	 /s/ Craig Squires

		 	Name: Craig Squires
		 	Title:   Managing Director

 
			
	Goldman Sachs Bank USA
		
	By:	 	 /s/ Michelle Latzoni

		 	Name: Michelle Latzoni
		 	Title:   Authorized Signatory

 
			
	Fifth Third Bank
		
	By:	 	 /s/ Thomas Avery

		 	Name: Thomas Avery
		 	Title:   Relationship Manager

 
			
	THE TORONTO-DOMINION BANK
		
	By:	 	 /s/ Marie Fernandes

		 	Name: Marie Fernandes
		 	Title:   Authorized Signatory

 
			
	THE TORONTO-DOMINION (TEXAS) LLC
		
	By:	 	 /s/ Marie Fernandes

		 	Name: Marie Fernandes
		 	Title:   Authorized Signatory

 
			
	Lloyds Bank PLC
		
	By:	 	 /s/ Dennis McClellan

		 	Name: Dennis McClellan
		 	Title:   Assistant Vice President M040
		
	By:	 	 /s/ Stephen Giacolone

		 	Name: Stephen Giacolone
		 	Title:   Assistant Vice President G011

 AMENDMENT NO. 1 TO CREDIT AGREEMENT 

AMENDMENT NO. 1 TO CREDIT AGREEMENT (this “Amendment”), dated as of November 15, 2013, is made with respect to the
Credit Agreement dated as of September 23, 2011, (as amended, restated, supplemented or otherwise modified prior to the date hereof, the “Credit Agreement”), among McKesson Corporation (the “Company”), McKesson
Canada Corporation (together with the Company, the “Borrowers”), the lenders from time to time party thereto, Bank of America, N.A., as administrative agent (the “Administrative Agent”), and Bank of America, N.A.,
as Canadian Administrative Agent (the “Canadian Administrative Agent”). 
 The parties hereto agree as follows: 

Section 1. Defined Terms. Capitalized terms used but not defined herein shall have the meanings given to them in the Credit
Agreement. 
 Section 2. Amendment.  

(a) Section 1.01 of the Credit Agreement is hereby amended by inserting the following terms in the appropriate alphabetical order: 

“Bidco” means Dragonfly GmbH & Co. KGaA, a limited partnership based on shares organized under the laws of Germany.

 “Celesio” means Celesio AG, a stock corporation organized under the laws of Germany. 

“Celesio Acquisition Closing Date” means the date on which Celesio first becomes a Subsidiary of the Borrower pursuant to the
private sale and tender offer contemplated by the Share Purchase Agreement, dated as of October 23, 2013, among the Borrower, Bidco and Franz Haniel & Cie. GmbH. 

“Celesio Bridge Facility” means that certain Senior Bridge Term Loan Agreement, dated as of October 23, 2013, among
McKesson Corporation, as borrower, the other lenders party thereto and Bank of America, N.A., as administrative agent. 
 “Celesio
Bridge Closing Date” means the “Closing Date” as such term is defined in the Celesio Bridge Facility. 
 “Celesio
Bridge Effective Date” means the October 23, 2013. 
 “Celesio Default” has the meaning specified in
Section 8.04.  
 “Clean-up Period” has the meaning specified in Section 8.04. 

 (b) Section 1.01 of the Credit Agreement is hereby amended by amending the definition of
“GAAP” therein set forth to add the following at the end thereof: 
 “; provided that, to the extent related to
Celesio, “GAAP” means either the foregoing or IFRS, consistently applied.” 
 (c) Section 7.04 of the Credit Agreement
is hereby amended and restated in its entirety as follows: 
 The Company shall not permit the ratio of Total Debt to Total Capitalization as
of the last day of any calendar month (x) prior to the Celesio Acquisition Closing Date to exceed 0.565 to 1.00 and (y) from the Celesio Acquisition Closing Date to exceed 0.65 to 1.00; provided that clause (y) shall not apply
(and clause (x) shall be deemed to apply at all times) if the Share Purchase Agreement, dated as of October 23, 2013, among the Borrower, Bidco and Franz Haniel & Cie. GmbH, has expired in accordance with its terms (after giving
effect to any amendment or extension thereof) and the Celesio Acquisition Closing Date has not occurred prior to such expiration. 
 (d) The
following Section 8.04 is hereby inserted after Section 8.03 of the Credit Agreement: 
 “8.04 Clean-up Period 

During the period beginning on the Celesio Bridge Closing Date and ending on the later of (i) 90 days from and including the Celesio
Bridge Closing Date and (ii) 60 days following the discovery by a Responsible Officer of the Company of a Celesio Default (as defined below), which discovery occurs within the time period referred to in clause (i) (the “Clean-up
Period”), none of the Administrative Agent or any Lender may (x) declare that a Default or an Event of Default has occurred (and no such Default or Event of Default will be deemed to otherwise exist hereunder during the Clean-Up
Period), or (y) terminate the Commitments, declare the Loans to be due and payable or require the Borrowers to Cash Collateralize the L/C Obligations and Bankers’ Acceptances as a result solely of one or more Defaults or Events of Default
described in Section 8.01, in each case, insofar as it relates to Celesio or any of its Subsidiaries (including for the avoidance of doubt any Default or Event of Default arising under Section 8.01(e) with respect to the Relevant
Obligations of Celesio) (a “Celesio Default”); provided that: 
 (a) the event or circumstance giving rise to such Celesio
Default, or the result of such Celesio Default, (i) directly relates to Celesio or any of its subsidiaries (or any of their businesses, assets or liabilities), (ii) is capable of being cured or remedied during the Clean-up Period and
(subject to any restrictions and limitations on the influence Bidco may exercise as shareholder of Celesio pursuant to mandatory German corporate law) commercially reasonable steps are taken by the Company or Bidco to remedy it, (iii) could not
reasonably be expected to have a Material Adverse Effect, (iv) has not been procured or approved by the Company or Bidco, and (v) was either not known by a Responsible Officer of the Borrower prior to the Celesio Bridge Effective Date or
was disclosed or otherwise described in the financial statements and reports of Celesio publicly filed prior to the Celesio Bridge Effective Date; and 

  
 2 

 (b) that the Administrative Agent and the Lenders shall be entitled to exercise any and all
rights and remedies granted to them hereunder and under the Loan Documents with respect to any such Default or Event of Default that is still in existence after the expiration of the Clean-up Period.” 

Section 3. Representations and Warranties. Each Borrower represents and warrants that: 

(a) the representations and warranties of such Borrower contained in Article V of the Credit Agreement shall be true and correct on and as of
the Amendment Effective Date (as defined below), except to the extent that such representations and warranties specifically refer to an earlier date, in which case they shall be true and correct as of such earlier date, and except that for purposes
of this Section 3 of this Amendment, the representations and warranties contained in Section 5.08(a) of the Credit Agreement shall be deemed to refer to the most recent financial statements furnished pursuant to Section 6.01(a) and
Section 6.01(b) of the Credit Agreement, respectively; and 
 (b) after giving effect to this Amendment, no event has occurred and is
continuing or will result from the consummation of the transactions contemplated by this Amendment that would constitute an Event of Default or a Default. 

Section 4. Effectiveness. This Amendment shall become effective on the date (the “Amendment Effective Date”) on
which each of the following conditions shall be satisfied: 
 (a) The Administrative Agent shall have received from each Borrower, the
Canadian Administrative Agent and the Lenders party hereto, who constitute the Required Lenders, either (i) a counterpart of this Amendment signed on behalf of such party or (ii) evidence satisfactory to the Administrative Agent that such
party has signed a counterpart of this Amendment; 
 (b) The Administrative Agent shall have received a certificate signed by a Responsible
Officer of the Company certifying that the representations and warranties contained in Section 3 of this Amendment are true and correct; and 

(c) The Borrower shall have paid all expenses of the Administrative Agent payable pursuant to Section 11.04(a) of the Credit Agreement to
the extent invoiced on or prior the Amendment Effective Date (including, without limitation, the reasonable fees and disbursements of counsel to the Administrative Agent). 

Section 5. Reference to and Effect Upon the Credit Agreement. 

(a) Except as expressly set forth herein, this Amendment shall not by implication or otherwise limit, impair, constitute a waiver of, or
otherwise affect the rights and remedies of the Lenders, the Administrative Agent, the Canadian Administrative Agentor any other party under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in any way affect any
of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect. 

  
 3 

 (b) Nothing herein shall be deemed to entitle any Loan Party to a consent to, or a waiver,
amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document in similar or different circumstances. 

(c) On and as of the Amendment Effective Date, each reference in the Credit Agreement to “this Agreement”, “hereof”,
“hereunder”, “herein” and “hereby” and each other similar reference, and each reference in any other Loan Document to “the Credit Agreement”, “thereof”, “thereunder”, “therein” or
“thereby” or any other similar reference to the Credit Agreement shall refer to the Credit Agreement as amended hereby. 

Section 6. Loan Document. This Amendment is a “Loan Document” under the Credit Agreement. 

Section 7. Governing Law. This Amendment shall be construed in accordance with and governed by the laws of the State of New York.

 Section 8. Counterparts. This Amendment may be signed in any number of counterparts by each of the Borrower, the
Administrative Agent, and the Lenders party hereto, each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument. Delivery of an executed counterpart hereof by facsimile or electronic
transmission (e.g., “pdf” or “tif”) shall be as effective as delivery of a manually executed counterpart hereof. 

[Remainder of page intentionally left blank]  

  
 4 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the date first above
written. 
  

					
	MCKESSON CORPORATION
		
	By:	 	 /s/ Nicholas Loiacono

		 	Name:	 	Nicholas Loiacono
		 	Title:	 	Vice President and Treasurer

 
					
	BANK OF AMERICA, N.A., as Administrative Agent
		
	By:	 	 /s/ Joan Mok

		 	Name:	 	Joan Mok
		 	Title:	 	Vice President
	
	BANK OF AMERICA, N.A. (acting through its Canada Branch), as Canadian Administrative Agent
		
	By:	 	 /s/ Medina Sales de Andrade

		 	Name:	 	Medina Sales de Andrade
		 	Title:	 	Vice President
	
	BANK OF AMERICA, N.A., as Lender
		
	By:	 	 /s/ Zubin R. Shroff

		 	Name:	 	Zubin R. Shroff
		 	Title:	 	Director
	
	BANK OF AMERICA, N.A. (acting through its Canada Branch), as Canadian Lender
		
	By:	 	 /s/ Medina Sales de Andrade

		 	Name:	 	Medina Sales de Andrade
		 	Title:	 	Vice President

 
					
	WELLS FARGO BANK, NATIONAL ASSOCIATION
		
	By:	 	 /s/ Kirk Tesch

		 	Name:	 	Kirk Tesch
		 	Title:	 	Director
	
	J.P. MORGAN CHASE BANK, N.A.
		
	By:	 	 /s/ Vanessa Chiu

		 	Name:	 	Vanessa Chiu
		 	Title:	 	Executive Director
	
	THE BANK OF TOKYO-MITSUBISHI UFJ, LTD.
		
	By:	 	 /s/ Jaime Sussman

		 	Name:	 	Jaime Sussman
		 	Title:	 	VP
	
	THE BANK OF NOVA SCOTIA
		
	By:	 	 /s/ Eugene Dempsey

		 	Name:	 	Eugene Dempsey
		 	Title:	 	Director
	
	U.S. BANK NATIONAL ASSOCIATION
		
	By:	 	 /s/ Conan Schleicher

		 	Name:	 	Conan Schleicher
		 	Title:	 	Senior Vice President
	
	U.S. BANK NATIONAL ASSOCIATION, CANADA BRANCH
		
	By:	 	 /s/ Joseph Rauhala

		 	Name:	 	Joseph Rauhala
		 	Title:	 	Principal Officer

 
					
	COÖPERATIEVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A., “RABOBANK NEDERLAND”, NEW YORK BRANCH
		
	By:	 	 /s/ Alan Pendergast

		 	Name:	 	Alan Pendergast
		 	Title:	 	Executive Director
		
	By:	 	 /s/ Deborah Dias

		 	Name:	 	Deborah Dias
		 	Title:	 	Executive Director
	
	GOLDMAN SACHS BANK USA
		
	By:	 	 /s/ Michelle Latzoni

		 	Name:	 	Michelle Latzoni
		 	Title:	 	Authorized Signatory
	
	PNC BANK NATIONAL ASSOCIATION
		
	By:	 	 /s/ Matthew D. Meister

		 	Name:	 	Matthew D. Meister
		 	Title:	 	Assistant Vice President
	
	FIFTH THIRD BANK
		
	By:	 	 /s/ Thomas Avery

		 	Name:	 	Thomas Avery
		 	Title:	 	Relationship Manager
		
	By:	 	 /s/ Karen Ahern

		 	Name:	 	Karen Ahern
		 	Title:	 	SVP
	
	HSBC BANK USA, N.A.
		
	By:	 	 /s/ Janet Lee

		 	Name:	 	Janet Lee
		 	Title:	 	Vice President

 
					
	TORONTO DOMINION (TEXAS) LLC
		
	By:	 	 /s/ Marie Fernandes

		 	Name:	 	Marie Fernandes
		 	Title:	 	Authorized Signatory
	
	THE TORONTO-DOMINION BANK
		
	By:	 	 /s/ Marie Fernandes

		 	Name:	 	Marie Fernandes
		 	Title:	 	Authorized Signatory
	
	LLOYDS BANK PLC
		
	By:	 	 /s/ Stephen Giacolone

		 	Name:	 	Stephen Giacolone
		 	Title:	 	Assistant Vice President G011
		
	By:	 	 /s/ Karen Weich

		 	Name:	 	Karen Weich
		 	Title:	 	Vice President W011

 Published CUSIP Number: 58155CAA2 

CREDIT AGREEMENT 
 Dated as
of September 23, 2011 
 McKESSON CORPORATION 

and 
 McKESSON CANADA
CORPORATION, 
 collectively, the Borrowers, 

BANK OF AMERICA, N.A.,  

as Administrative Agent, 
 BANK
OF AMERICA, N.A. (acting through  
 its Canada branch), as Canadian Administrative Agent, 

JPMORGAN CHASE BANK, N.A. 

and 
 WELLS FARGO BANK, NATIONAL
ASSOCIATION, 
 as Co-Syndication Agents, 

WELLS FARGO BANK, NATIONAL ASSOCIATION, 

as L/C Issuer, 
 THE BANK OF
TOKYO-MITSUBISHI UFJ, LTD., 
 THE BANK OF NOVA SCOTIA, 

and 
 U.S. BANK NATIONAL
ASSOCIATION 
 as Co-Documentation Agents, 

and 
 The Other Lenders Party
Hereto 
 MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED, 

Sole Lead Arranger and Sole Book Manager 

							
	ARTICLE I	  	DEFINITIONS AND ACCOUNTING TERMS	  	 	1	  
			
	1.01	  	Defined Terms	  	 	1	  
			
	1.02	  	Other Interpretive Provisions	  	 	22	  
			
	1.03	  	Accounting Terms	  	 	23	  
			
	1.04	  	Rounding	  	 	23	  
			
	1.05	  	References to Agreements and Laws	  	 	23	  
			
	1.06	  	Times of Day	  	 	24	  
			
	1.07	  	Letter of Credit Amounts	  	 	24	  
			
	ARTICLE II	  	THE COMMITMENTS AND CREDIT EXTENSIONS	  	 	24	  
			
	2.01	  	Committed Loans	  	 	24	  
			
	2.02	  	Borrowings, Conversions and Continuations of Committed Loans	  	 	26	  
			
	2.03	  	Letters of Credit	  	 	28	  
			
	2.04	  	Bankers’ Acceptances for McKesson Canada	  	 	36	  
			
	2.05	  	Prepayments	  	 	42	  
			
	2.06	  	Termination or Reduction of Commitments	  	 	42	  
			
	2.07	  	Repayment of Loans	  	 	43	  
			
	2.08	  	Interest	  	 	43	  
			
	2.09	  	Fees	  	 	44	  
			
	2.10	  	Computation of Interest and Fees	  	 	44	  
			
	2.11	  	Evidence of Debt	  	 	44	  
			
	2.12	  	Payments Generally	  	 	45	  
			
	2.13	  	Sharing of Payments	  	 	47	  
			
	2.14	  	Currency Exchange Fluctuations	  	 	47	  
			
	2.15	  	Increase in Commitments	  	 	48	  
			
	2.16	  	Utilization of Commitments in Canadian Dollars	  	 	49	  
			
	2.17	  	Extension of Maturity Date	  	 	49	  
			
	2.18	  	Defaulting Lenders	  	 	51	  
			
	ARTICLE III	  	TAXES, YIELD PROTECTION AND ILLEGALITY	  	 	53	  
			
	3.01	  	Taxes	  	 	53	  
			
	3.02	  	Illegality	  	 	54	  
			
	3.03	  	Inability to Determine Rates	  	 	55	  
			
	3.04	  	Increased Cost and Reduced Return; Capital Adequacy	  	 	55	  
			
	3.05	  	Funding Losses	  	 	56	  
			
	3.06	  	Matters Applicable to all Requests for Compensation	  	 	57	  
			
	3.07	  	Survival	  	 	57	  
			
	ARTICLE IV	  	CONDITIONS PRECEDENT TO CREDIT EXTENSIONS	  	 	57	  
			
	4.01	  	Conditions to Effectiveness	  	 	57	  
			
	4.02	  	Existing Revolving Credit Agreement	  	 	59	  
			
	4.03	  	Conditions to all Credit Extensions	  	 	60	  
			
	ARTICLE V	  	REPRESENTATIONS AND WARRANTIES	  	 	61	  
			
	5.01	  	Corporate Existence and Power	  	 	61	  

  
 i 

							
			
	5.02	  	Corporate Authorization; No Contravention	  	 	61	  
			
	5.03	  	Governmental Authorization	  	 	61	  
			
	5.04	  	Binding Effect	  	 	61	  
			
	5.05	  	Litigation	  	 	62	  
			
	5.06	  	No Default	  	 	62	  
			
	5.07	  	Use of Proceeds; Margin Regulations	  	 	62	  
			
	5.08	  	Financial Condition	  	 	62	  
			
	5.09	  	Regulated Entities	  	 	62	  
			
	5.10	  	No Burdensome Restrictions	  	 	62	  
			
	5.11	  	Subsidiaries	  	 	63	  
			
	5.12	  	Secured Indebtedness	  	 	63	  
			
	5.13	  	Taxes	  	 	63	  
			
	ARTICLE VI	  	AFFIRMATIVE COVENANTS	  	 	63	  
			
	6.01	  	Financial Statements	  	 	63	  
			
	6.02	  	Certificates; Other Information	  	 	64	  
			
	6.03	  	Notices	  	 	65	  
			
	6.04	  	Preservation of Existence, Etc	  	 	65	  
			
	6.05	  	Maintenance of Insurance	  	 	66	  
			
	6.06	  	Payment of Taxes	  	 	66	  
			
	6.07	  	Compliance with Laws	  	 	66	  
			
	6.08	  	Books and Records	  	 	66	  
			
	6.09	  	Inspection Rights	  	 	66	  
			
	6.10	  	Use of Proceeds	  	 	66	  
			
	ARTICLE VII	  	NEGATIVE COVENANTS	  	 	67	  
			
	7.01	  	Liens	  	 	67	  
			
	7.02	  	Consolidations and Mergers	  	 	68	  
			
	7.03	  	Use of Proceeds	  	 	69	  
			
	7.04	  	Maximum Debt to Capitalization Ratio	  	 	69	  
			
	7.05	  	Swap Contracts	  	 	69	  
			
	ARTICLE VIII	  	EVENTS OF DEFAULT AND REMEDIES	  	 	69	  
			
	8.01	  	Events of Default	  	 	69	  
			
	8.02	  	Remedies Upon Event of Default	  	 	71	  
			
	8.03	  	Application of Funds	  	 	72	  
			
	ARTICLE IX	  	ADMINISTRATIVE AGENT	  	 	72	  
			
	9.01	  	Appointment and Authorization of Agents	  	 	72	  
			
	9.02	  	Rights as a Lender	  	 	73	  
			
	9.03	  	Exculpatory Provisions	  	 	73	  
			
	9.04	  	Delegation of Duties	  	 	74	  
			
	9.05	  	Reliance by Agents	  	 	74	  
			
	9.06	  	Successor Agents	  	 	75	  
			
	9.07	  	Non-Reliance on Agents and Other Lenders	  	 	75	  

  
 ii 

							
			
	9.08	  	No Other Duties, Etc	  	 	75	  
			
	9.09	  	Administrative Agent May File Proofs of Claim	  	 	75	  
			
	ARTICLE X	  	THE COMPANY’S GUARANTY OF OTHER BORROWERS’ OBLIGATIONS	  	 	76	  
			
	10.01	  	Guaranty of the Guarantied Obligations	  	 	76	  
			
	10.02	  	Liability of the Company Absolute	  	 	77	  
			
	10.03	  	Waivers by the Company	  	 	78	  
			
	10.04	  	Payment by the Company; Application of Payments	  	 	79	  
			
	10.05	  	Guarantor’s Rights of Subrogation, Contribution, Etc	  	 	80	  
			
	10.06	  	Subordination of Other Obligations	  	 	80	  
			
	10.07	  	[RESERVED]	  	 	81	  
			
	10.08	  	Expenses	  	 	81	  
			
	10.09	  	Continuing Guaranty; Termination of Guaranty	  	 	81	  
			
	10.10	  	Authority of the Company or any Guarantied Borrower	  	 	81	  
			
	10.11	  	Financial Condition of Guarantied Borrowers	  	 	81	  
			
	10.12	  	Rights Cumulative	  	 	81	  
			
	10.13	  	Bankruptcy; Post-Petition Interest; Reinstatement of Guaranty	  	 	81	  
			
	ARTICLE XI	  	MISCELLANEOUS	  	 	82	  
			
	11.01	  	Amendments, Etc	  	 	82	  
			
	11.02	  	Notices and Other Communications; Facsimile Copies	  	 	83	  
			
	11.03	  	No Waiver; Cumulative Remedies; Enforcement	  	 	85	  
			
	11.04	  	Expenses; Indemnity; Damage Waiver	  	 	86	  
			
	11.05	  	Payments Set Aside	  	 	88	  
			
	11.06	  	Successors and Assigns	  	 	88	  
			
	11.07	  	Treatment of Certain Information; Confidentiality	  	 	93	  
			
	11.08	  	Set-off	  	 	94	  
			
	11.09	  	Interest Rate Limitation	  	 	94	  
			
	11.10	  	Counterparts	  	 	94	  
			
	11.11	  	Integration	  	 	94	  
			
	11.12	  	Survival of Representations and Warranties	  	 	95	  
			
	11.13	  	Severability	  	 	95	  
			
	11.14	  	Tax Forms	  	 	95	  
			
	11.15	  	Replacement of Lenders	  	 	98	  
			
	11.16	  	Governing Law	  	 	99	  
			
	11.17	  	Waiver of Right to Trial by Jury	  	 	99	  
			
	11.18	  	No Advisory or Fiduciary Responsibility	  	 	100	  
			
	11.19	  	USA Patriot Act Notice	  	 	100	  
			
	11.20	  	Judgment	  	 	100	  
			
	11.21	  	Limitation of McKesson Canada Liability	  	 	101	  

  
 iii 

			
	SCHEDULES
		
	2.01	 	Commitments, Pro Rata Shares and Affiliate Banks
		
	5.11	 	Subsidiaries
		
	5.12	 	Material Secured Indebtedness
		
	11.02    	 	Administrative Agent’s Office, Certain Addresses for Notices
	
	EXHIBITS
		
	A	 	Form of Committed Loan Notice
		
	B-1	 	Form of Note (McKesson Corporation)
		
	B-2	 	Form of Note (McKesson Canada Corporation)
		
	C	 	Form of Compliance Certificate
		
	D	 	Form of Assignment and Assumption
		
	E	 	Form of Drawing Notice
		
	F	 	Form of Joinder Agreement
		
	G	 	Form of Domestic Borrower Notice

  
 iv 

 CREDIT AGREEMENT 

This CREDIT AGREEMENT (“Agreement”) is entered into as of September 23, 2011, among McKESSON CORPORATION, a Delaware
corporation (the “Company”), McKESSON CANADA CORPORATION, a Nova Scotia unlimited company and indirect wholly owned subsidiary of the Company (“McKesson Canada”), any Subsidiary of the Company that has executed and
delivered to the Administrative Agent a joinder agreement in the form of Exhibit F hereto pursuant to Section 7.02(d) (together with the Company and McKesson Canada, the “Borrowers” and each a
“Borrower”), each lender from time to time party hereto (collectively, the “Lenders” and each individually, a “Lender”), BANK OF AMERICA, N.A. acting through its Canada branch, as Canadian
Administrative Agent with respect to the Canadian Loans and the Bankers’ Acceptance Facility (as hereinafter defined), BANK OF AMERICA, N.A., as Administrative Agent, and WELLS FARGO BANK, NATIONAL ASSOCIATION, as L/C Issuer. 

The Borrowers have requested that the Lenders make available, for the purposes specified in this Agreement, a revolving credit facility, and
the Lenders are willing to make available to the Borrowers such revolving credit facility upon the terms and subject to the conditions set forth herein. 

In consideration of the mutual covenants and agreements herein contained, the parties hereto covenant and agree as follows: 

ARTICLE I 
 DEFINITIONS
AND ACCOUNTING TERMS 
 1.01 Defined Terms. As used in this Agreement (including the introductory clauses hereto), the following terms shall have
the meanings set forth below: 
 “Acceptance Usage” means, as at any date of determination, the aggregate Face Amount of
all completed Bankers’ Acceptances which have not been repaid by McKesson Canada whether or not due and whether or not held by a Lender. For purposes of this definition, any Bankers’ Acceptance that has been prepaid in full shall not be
deemed to be outstanding and all Bankers’ Acceptances shall be valued in Dollar Equivalents as of the applicable Computation Date. 

“Acquired Debt Default” means an event of default under a Relevant Obligation of a Person which becomes a Subsidiary after
the date hereof, which event of default occurs by reason of the change of control of such Person by virtue of the transaction pursuant to which it becomes a Subsidiary. For avoidance of doubt, an event of default under another Relevant Obligation of
the Company or a Subsidiary by virtue of a cross default to an event of default described in the preceding sentence is not an Acquired Debt Default. 

“Additional Commitment Lender” has the meaning specified in Section 2.17. 

“Administrative Agent” means Bank of America, N.A. in its capacity as administrative agent under any of the Loan Documents,
or any successor administrative agent. 
 “Administrative Agent’s Office” means the Administrative Agent’s
address and, as appropriate, account as set forth on Schedule 11.02, or such other address or account as the Administrative Agent may from time to time notify the Borrowers and the Lenders. 

“Administrative Questionnaire” means an Administrative Questionnaire in a form supplied by the Administrative Agent. 

 “Affiliate” means, with respect to any Person, another Person that directly, or
indirectly through one or more intermediaries, Controls or is Controlled by or is under common Control with the Person specified. “Control” means the possession, directly or indirectly, of the power to direct or cause the direction
of the management or policies of a Person, whether through the ability to exercise voting power, by contract or otherwise. “Controlling” and “Controlled” have meanings correlative thereto. 

“Agent Parties” has the meaning specified in Section 11.02(c). 

“Agents” means the Administrative Agent and the Canadian Administrative Agent. 

“Aggregate Canadian Commitments” means the aggregate Canadian Commitments of all the Canadian Lenders, which is an amount
equal to $200,000,000 on the date hereof. The Aggregate Canadian Commitments are a part of, and not an addition to, the Aggregate Commitments. 

“Aggregate Commitments” means the aggregate Commitments of all the Lenders. 

“Agreement” means this Credit Agreement. 

“Anniversary Date” has the meaning specified in Section 2.17. 

“Applicable Agent” means (a) the Administrative Agent in the case of Domestic Loans and Letters of Credit and
(b) the Canadian Administrative Agent in the case of Canadian Loans and in connection with the Bankers’ Acceptance Facility. 

“Applicable Borrower” means (a) any Domestic Borrower, in the case of Domestic Loans and Letters of Credit and
(b) McKesson Canada, in the case of Canadian Loans and Bankers’ Acceptances. 
 “Applicable Currency” means, as
to any particular payment or Loan, Dollars in the case of Domestic Loans and Letters of Credit and Canadian Dollars in the case of Canadian Loans and the Bankers’ Acceptance Facility. 

“Applicable Rate” means, from time to time, the rate, expressed in basis points per annum, corresponding to the applicable
Debt Rating as set forth below: 
  

															
	 Pricing
Level
	  	 Debt Ratings

S&P/Moody’s/Fitch
	  	Facility
Fee	 	  	Eurodollar Rate
Loans, Letters of
Credit and Bankers’
Acceptances	 	  	Base Rate Loans and
Canadian Prime
Rate Loans	 
	 1
	  	Greater than or equal to A+/A1/A+	  	 	7.0	  	  	 	68.0	  	  	 	0	  
	 2
	  	A/A2/A	  	 	8.0	  	  	 	79.5	  	  	 	0	  
	 3
	  	A-/A3/A-	  	 	10.0	  	  	 	90.0	  	  	 	0	  
	 4
	  	BBB+/Baa1/BBB+	  	 	12.5	  	  	 	112.5	  	  	 	12.5	  
	 5
	  	Less than or equal to BBB/Baa2/BBB	  	 	15.0	  	  	 	135.0	  	  	 	35	  

 “Debt Rating” means, as of any date of determination, the available ratings as
determined by S&P, Moody’s and/or Fitch (collectively, the “Debt Ratings”) of the Company’s non-credit-enhanced, senior unsecured long-term debt; provided that (a) if the Company shall maintain a

  
 2 

 
rating of its non-credit-enhanced, senior unsecured long-term debt from only two of S&P, Moody’s and Fitch then the higher of such Debt Ratings shall apply (with the Debt Rating for
Pricing Level 1 being the highest and the Debt Rating for Pricing Level 6 being the lowest), unless there is a split in Debt Ratings of more than one Pricing Level, in which case the Applicable Rate shall be determined by reference to a Debt Rating
that is one Pricing Level lower than the higher of the Company’s two Debt Ratings, (b) if the Company shall maintain a Debt Rating of its non-credit-enhanced, senior unsecured long-term debt from only one of S&P, Moody’s and
Fitch, then that single Debt Rating shall apply, (c) if the Company shall maintain a Debt Rating of its non-credit-enhanced, senior unsecured long-term debt from all three of S&P, Moody’s and Fitch and there is a difference in such
Debt Ratings, (i) if there is a difference of only one Pricing Level between the highest and lowest of such Debt Ratings, the Applicable Rate shall be determined by reference to the higher Debt Rating, and (ii) if there is a difference of
more than one Pricing Level between any of the Debt Ratings, and if two Debt Ratings are equivalent and the third Debt Rating is lower, the Applicable Rate shall be determined by reference to the higher Debt Rating; otherwise the Applicable Rate
shall be determined by reference to a Debt Rating that is one Pricing Level below the highest of the Company’s three Debt Ratings and (d) if the Company shall fail to maintain any Debt Rating of its non-credit-enhanced, senior unsecured
long-term debt from any of S&P, Moody’s and Fitch, then the Applicable Rate shall be the same as the Applicable Rate that would apply if the Company had the lowest Debt Ratings set forth in the Applicable Rate grid above. 

Initially, the Applicable Rate shall be determined based upon the Debt Rating specified in the certificate delivered pursuant
to Section 4.01(a)(vi). Thereafter, each change in the Applicable Rate resulting from a publicly announced change in the Debt Rating shall be effective, in the case of an upgrade, during the period commencing on the date of delivery by
the Company to the Administrative Agent of notice thereof pursuant to Section 6.03(e) and ending on the date immediately preceding the effective date of the next such change and, in the case of a downgrade, during the period commencing
on the date of the public announcement thereof and ending on the date immediately preceding the effective date of the next such change. 

“Approved Fund” means any Fund that is administered or managed by (a) a Lender, (b) an Affiliate of a Lender or
(c) an entity or an Affiliate of an entity that administers or manages a Lender. 
 “Arranger” means Merrill Lynch,
Pierce, Fenner & Smith Incorporated, in its capacity as sole lead arranger and sole book manager. 
 “Assignment and
Assumption” means an Assignment and Assumption substantially in the form of Exhibit D. 
 “Attorney Costs”
means and includes all fees, expenses and disbursements of any law firm or other external counsel and, without duplication, the allocated cost of internal legal services and all expenses and disbursements of internal counsel; provided that no
fees, expenses or disbursements shall qualify as Attorney Costs unless written evidence substantiating such fees, expenses and disbursements is available to the Company upon request. 

“Attributable Indebtedness” means, on any date, (a) in respect of any capital lease of any Person, the capitalized
amount thereof that would appear on a balance sheet of such Person prepared as of such date in accordance with GAAP, and (b) in respect of any Synthetic Lease Obligation, the capitalized amount of the remaining lease payments under the relevant
lease that would appear on a balance sheet of such Person prepared as of such date in accordance with GAAP if such lease were accounted for as a capital lease. 

  
 3 

 “Audited Financial Statements” means the audited consolidated balance sheet of
the Company and its Subsidiaries for the fiscal year ended March 31, 2011, and the related consolidated statements of operations, shareholders’ equity and cash flows for such fiscal year of the Company and its Subsidiaries, including the
notes thereto. 
 “Availability Period” means the period from and including the date hereof to the earliest of (a) the
Maturity Date, (b) the date of termination of the Aggregate Commitments pursuant to Section 2.06, and (c) the date of termination of the commitment of each Lender to make Loans and of the obligation of the of the L/C Issuer to
make L/C Credit Extensions pursuant to Section 8.02. 
 “BA Canada” means Bank of America, N.A. (acting through
its Canada branch), and its successors. 
 “Bank of America” means Bank of America, N.A. and its successors. 

“Bankers’ Acceptance” has the meaning set forth in Section 2.04(a). 

“Bankers’ Acceptance Credit Extension” means, with respect to any Bankers’ Acceptance, the acceptance thereof or
the renewal or increase of the amount thereof. 
 “Bankers’ Acceptance Facility” means the facility established by
Section 2.04(a). 
 “Base Rate” means for any day a fluctuating rate per annum equal to the highest of
(a) the Federal Funds Rate plus 1/2 of 1%, (b) the rate of interest in effect for such day as publicly announced from time to time by Bank of America as its “prime rate,” and (c) the Eurodollar Rate plus 1%. The “prime
rate” is a rate set by Bank of America based upon various factors including Bank of America’s costs and desired return, general economic conditions and other factors, and is used as a reference point for pricing some loans, which may be
priced at, above, or below such announced rate. Any change in such rate announced by Bank of America shall take effect at the opening of business on the day specified in the public announcement of such change. 

“Base Rate Committed Loan” means a Committed Loan that is a Base Rate Loan. 

“Base Rate Loan” means a Loan that bears interest based on the Base Rate. 

“Beneficiary” means, in relation to a Letter of Credit, from time to time, the initial beneficiary, a transferee beneficiary,
a successor beneficiary, a nominated bank, a negotiating bank or a confirming bank with respect to such Letter of Credit, as applicable. 

“Borrower” has the meaning specified in the introductory paragraph hereto. 

“Borrower Materials” has the meaning specified in Section 6.02. 

“Borrowing” means a borrowing consisting of simultaneous Committed Loans of the same Type and, in the case of Eurodollar Rate
Loans, having the same Interest Period made by each of the Lenders pursuant to Section 2.01. 
 “Business Day”
means any day other than a Saturday, Sunday or other day on which commercial banks are authorized to close under the Laws of, or are in fact closed in, Charlotte, North Carolina or San Francisco, California, or, in the case of Canadian Loans or in
connection with the Bankers’ Acceptance Facility, Toronto, are authorized or required by law to close and, if such day relates to any Eurodollar Rate Loan, means any such day on which dealings in Dollar deposits are conducted by and between
banks in the London interbank eurodollar market. 

  
 4 

 “Canadian Administrative Agent” means BA Canada, in its capacity as the Canadian
administrative agent for the Canadian Lenders, and any successor Canadian administrative agent. 
 “Canadian Administrative
Agent’s Office” means the Canadian Administrative Agent’s address and, as appropriate, account as set forth on Schedule 11.02, or such other address or account as the Canadian Administrative Agent may from time to time
notify the Borrowers and Canadian Lenders. 
 “Canadian Commitment” means, as to each Canadian Lender, an aggregate amount
equal to the amount set forth opposite its name in the column under the heading “Canadian Commitments” on Schedule 2.01 or in the Assignment and Assumption pursuant to which such Lender becomes a party hereto, as applicable, as such
amount may be adjusted from time to time in accordance with this Agreement. 
 “Canadian Dollars” and
“Cdn.$” each means the lawful money of Canada. 
 “Canadian Exposure” means, as to any Canadian Lender
(a) prior to the termination of the Canadian Commitment, such Canadian Lender’s Canadian Commitment and (b) after the termination of the Canadian Commitment, the Total Canadian Outstandings for such Canadian Lender. 

“Canadian Lender” means each Canadian bank listed on Schedule 2.01 as a Canadian Lender, and their successors and
assigns. 
 “Canadian Loan” means any Loan made to McKesson Canada pursuant to Section 2.01(b) denominated in
Canadian Dollars, which may be a Eurodollar Rate Loan or a Canadian Prime Rate Loan. 
 “Canadian Participant” has the
meaning set forth in Section 2.01(b)(ii). 
 “Canadian Participation” has the meaning set forth in
Section 2.01(b)(ii). 
 “Canadian Prime Rate” means, for any day, with respect to any Canadian Loan, a
fluctuating rate per annum equal to the higher of (a) the rate announced by the Canadian Administrative Agent from time to time as its prime lending rate, as in effect from time to time, and (b) a rate equal to the CDOR that would apply to
a one-month Bankers’ Acceptance accepted by BA Canada if made on such day plus 0.75% per annum. As to any loan, the Canadian Prime Rate is a reference rate and does not necessarily represent the lowest or best rate actually charged to any
customer. The Canadian Administrative Agent may make commercial loans or other loans at rates of interest at, above or below the Canadian Prime Rate. Any change in the reference rate announced by the Canadian Administrative Agent shall take effect
at the opening of business on the day specified in the announcement of such change. 
 “Canadian Prime Rate Loans” means
Canadian Loans bearing interest at rates determined by reference to the Canadian Prime Rate. 
 “Canadian Pro Rata Share”
means, as to any Canadian Lender at any time, the percentage equivalent (expressed as a decimal, rounded to the ninth decimal place) at such time of such Canadian Lender’s Canadian Exposure divided by the combined Canadian Exposure of all
Canadian Lenders (including, in each case, Canadian Exposure of Affiliates of Canadian Lenders). The initial Canadian Pro Rata Share of each Canadian Lender is set forth opposite the name of such Canadian Lender on Schedule 2.01 or in the
Assignment and Assumption pursuant to which such Canadian Lender becomes a party hereto, as applicable. 

  
 5 

 “Canadian Resident” shall mean a Person that is either (a) a resident of
Canada for purposes of the Income Tax Act (Canada) or (b) the Canada branch of an authorized foreign bank that will receive all amounts contemplated under this agreement as part of its Canadian banking business for purposes of the Income Tax
Act (Canada). 
 “Canadian Spot Rate” means the rate quoted by Bank of America as the spot rate for the purchase by Bank of
America of such currency with another currency through its FX Trading Office at approximately 8:00 a.m. on the Computation Date. 

“Cash Collateralize” has the meaning specified in Section 2.03(g). 

“CDOR” means, for any day and relative to Bankers’ Acceptances having any specified Face Amount and maturity, the
average of the annual rates for Bankers’ Acceptances having such specified Face Amount and maturity (or a Face Amount and maturity as closely as possible comparable to such specified Face Amount and maturity) of the banks named in
Schedule I to the Bank Act (Canada) that appears on the Reuters Screen CDOR page as of at 10:00 a.m. (Eastern time) on such day (or, if such day is not a Business Day, as of 10:00 a.m. (Eastern time) on the next preceding Business Day),
provided that if such rate does not appear on the Reuters Screen CDOR page at such time on such date, CDOR for such date will be the annual rate of interest (rounded upward to the nearest whole multiple of 1/100 of 1% calculated) as of 10:00 a.m.
(Eastern time) on such date on the basis of the discount amount at which the Canadian Administrative Agent is then offering to purchase Bankers’ Acceptances accepted by it having a comparable aggregate Face Amount and identical maturity date to
the aggregate Face Amount and maturity date of such Bankers’ Acceptances. 
 “Change in Law” means the occurrence,
after the date of this Agreement, of any of the following: (a) the adoption or taking effect of any law, rule, regulation or treaty, (b) any change in any law, rule, regulation or treaty or in the administration, interpretation,
implementation or application thereof by any Governmental Authority or (c) the making or issuance of any request, rule, guideline or directive (whether or not having the force of law) by any Governmental Authority; provided that
notwithstanding anything herein to the contrary, (x) the Dodd-Frank Wall Street Reform and Consumer Protection Act and all requests, rules, guidelines or directives thereunder or issued in connection therewith and (y) all requests, rules,
guidelines or directives promulgated by the Bank for International settlements, the Basel Committee on Banking Supervision (or any successor or similar authority) or the United States regulatory authorities, in each case pursuant to Basel III, shall
in each case be deemed to be a “Change in Law”, regardless of the date enacted, adopted or issued. 
 “Change of
Control” means an event or series of events by which: 
 (a)(i) with respect to the Company, any
“person” or “group” (as such terms are used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, but excluding any employee benefit plan of such person or its subsidiaries, and any person or entity acting in its
capacity as trustee, agent or other fiduciary or administrator of any such plan) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Securities Exchange Act of 1934, except that a person or group shall be deemed
to have “beneficial ownership” of all securities that such person or group has the right to acquire, whether such right is exercisable immediately or only after the passage of time (such right, an “option right”)),
directly or indirectly, of 51% or more of the equity securities of the Company entitled to vote for members of the board of directors or equivalent governing body of the Company on a fully-diluted basis (and taking into account all such securities
that such person or group has the right to acquire pursuant to any option right) 

  
 6 

 
(provided that “Change of Control” shall not include any such acquisition which occurs as part of a transaction consisting of (x) the Company becoming a wholly owned
subsidiary of a holding company and (y) the holders of the voting stock of such holding company immediately following such transaction are substantially the same as the holders of the Company’s voting stock immediately prior to such
transaction) and (ii) with respect to the Domestic Subsidiary that becomes a Borrower pursuant to Section 7.02(d), any “person” or “group” other than the Company becomes the “beneficial owner”, directly or
indirectly, of any equity securities of such Domestic Subsidiary entitled to vote for members of the board of directors or equivalent governing body of such Domestic Subsidiary on a fully-diluted basis; or 

(b) during any period of 12 consecutive months, a majority of the members of the board of directors or other equivalent
governing body of the Company cease to be composed of individuals (i) who were members of that board or equivalent governing body on the first day of such period, (ii) whose election or nomination to that board or equivalent governing body
was approved by individuals referred to in clause (i) above constituting at the time of such election or nomination at least a majority of that board or equivalent governing body or (iii) whose election or nomination to that board or other
equivalent governing body was approved by individuals referred to in clauses (i) and (ii) above constituting at the time of such election or nomination at least a majority of that board or equivalent governing body (excluding, in the case
of both clause (ii) and clause (iii), any individual whose initial nomination for, or assumption of office as, a member of that board or equivalent governing body occurs as a result of an actual or threatened solicitation of proxies or consents
for the election or removal of one or more directors by any person or group other than a solicitation for the election of one or more directors by or on behalf of the board of directors). 

“Clearing House” means The Canadian Depository for Securities Limited, or such alternative clearing house within the meaning
of The Depository Bills and Notes Act (Canada). 
 “Code” means the Internal Revenue Code of 1986. 

“Commitment” means, as to each Lender, its obligation to (a) make Committed Loans (including any Canadian Commitment of
any Canadian Lender to make Canadian Loans or purchase Bankers’ Acceptances) to the Borrowers pursuant to Article II and (b) purchase participations in L/C Obligations, in an aggregate principal amount at any one time outstanding
not to exceed the amount set forth opposite such Lender’s name on Schedule 2.01 or in the Assignment and Assumption pursuant to which such Lender becomes a party hereto, as applicable, as such amount may be adjusted from time to time in
accordance with this Agreement. The Commitment for any Lender that has an Affiliate is a single value for such Lender and its Affiliate taken together. 

“Committed Loan” means a Domestic Loan or a Canadian Loan. 

“Committed Loan Notice” means a notice of (a) a Borrowing, (b) a conversion of Committed Loans from one Type to the
other, or (c) a continuation of Eurodollar Rate Loans, pursuant to Section 2.02(a), which, if in writing, shall be substantially in the form of Exhibit A. 

“Company” has the meaning specified in the introductory clause hereto. 

“Company Guaranty” means the Company’s guaranty of the Obligations of each other Borrower, the terms of which guaranty
are located in Article X of this Agreement. 
 “Compliance Certificate” means a certificate substantially in the
form of Exhibit C. 

  
 7 

 “Computation Date” has the meaning specified in Section 2.16(a).

 “Contractual Obligation” means, as to any Person, any provision of any security issued by such Person or of any
agreement, instrument or other undertaking to which such Person is a party or by which it or any of its property is bound. 

“Control” has the meaning specified in the definition of “Affiliate.” 

“Credit Extension” means each of the following: (a) a Borrowing, (b) a Bankers’ Acceptance Credit Extension
and (c) an L/C Credit Extension. 
 “Debt Rating” has the meaning specified in the definition of “Applicable
Rate.” 
 “Debtor Relief Laws” means the Bankruptcy Code of the United States, the Bankruptcy and Insolvency Act
(Canada), the Companies’ Creditors Arrangement Act (Canada) and all other liquidation, conservatorship, bankruptcy, assignment for the benefit of creditors, moratorium, rearrangement, receivership, insolvency, reorganization, or similar debtor
relief Laws of the United States or other applicable jurisdictions from time to time in effect and affecting the rights of creditors generally. 

“Default” means any event or condition that constitutes an Event of Default or that, with the giving of any notice, the
passage of time, or both, would be an Event of Default. 
 “Default Rate” means an interest rate equal to (a) the Base
Rate plus (b) the Applicable Rate, if any, applicable to Base Rate Loans plus (c) 2% per annum; provided, however, that, with respect to a Eurodollar Rate Loan or Canadian Prime Rate Loan, the Default Rate shall
be an interest rate equal to the interest rate (including any Applicable Rate) otherwise applicable to such Loan plus 2% per annum, in each case to the fullest extent permitted by applicable Laws. 

“Defaulting Lender” means, subject to Section 2.18, (a) any Lender that (i) has failed to fund any
portion of the Committed Loans or participations in L/C Obligations required to be funded by it hereunder within one Business Day of the date required to be funded by it hereunder, unless such Lender notifies the Administrative Agent in writing that
such failure is the result of such Lender’s determination that one or more conditions precedent to funding (which conditions precedent, together with the applicable default, if any, shall be specifically identified in such writing) has not been
satisfied, (ii) has otherwise failed to pay over to the Administrative Agent or any other Lender any other amount required to be paid by it hereunder within one Business Day of the date when due, unless the subject of a good faith dispute,
(iii) has notified any Borrower, the Administrative Agent or any other Lender that it does not intend to comply with its funding obligations or has made a public statement to that effect with respect to its funding obligations hereunder (unless
such writing or public statement relates to such Lenders’ obligation to fund a Loan hereunder and states that such position is based on such Lender’s determination that a condition precedent to funding (which condition precedent, together
with the applicable default, if any, shall be specifically identified in such writing or public statement) cannot be satisfied) or under other agreements in which it commits to extend credit, (iv) has failed, within three (3) Business Days
after request by the Administrative Agent, to confirm in a manner satisfactory to the Administrative Agent that it will comply with its funding obligations hereunder (provided that such Lender shall cease to be a Defaulting Lender pursuant to
this clause (iv) upon receipt of such written confirmation by the Administrative Agent), (v) has, or has a direct or indirect parent company that has, (x) become the subject of an Insolvency Proceeding, (y) had a receiver,
conservator, trustee, administrator, assignee for the benefit of creditors or similar Person charged with reorganization or liquidation of its business or a custodian appointed for it, or (z) taken any action in furtherance of, or indicated its
consent to, approval of or acquiescence in any such proceeding or appointment (provided 

  
 8 

 
that a Lender shall not be a Defaulting Lender solely by virtue of the ownership or acquisition of any equity interest in that Lender or any direct or indirect parent company thereof by a
Governmental Authority) and (b) any Canadian Lender that has failed to purchase any Draft or Bankers’ Acceptance. 

“Dollar” and “$” mean lawful money of the United States. 

“Dollar Equivalent” means, at any time, (a) as to any amount denominated in Dollars, the amount thereof at such time,
and (b) as to any amount denominated in Canadian Dollars, the equivalent amount in Dollars as determined by the Applicable Agent at such time on the basis of the Canadian Spot Rate for the purchase of Dollars with Canadian Dollars on the most
recent Computation Date provided for in Section 2.16(a). 
 “Domestic Borrower” means the Company and the
Domestic Subsidiary that has become a Borrower pursuant to a joinder agreement in the form of Exhibit F as contemplated by Section 7.02(d). 

“Domestic Borrower Notice” has the meaning specified in Section 7.02(d). 

“Domestic Lender” means each Lender acting in the capacity of a domestic lender listed on Schedule 2.01 as a Domestic
Lender, and their successors and assigns. 
 “Domestic Loan” means any Loan made to a Domestic Borrower pursuant to
Section 2.01(a) denominated in Dollars, which may be a Eurodollar Rate Loan or a Base Rate Loan. 
 “Domestic
Subsidiary” means each Subsidiary of the Company that is organized or existing under the laws of the United States, any state of the United States or the District of Columbia. 

“Draft” means, at any time, a bill of exchange, within the meaning of the Bills of Exchange Act (Canada) drawn by McKesson
Canada to be accepted by a Canadian Lender (which upon such acceptance will be a Bankers’ Acceptance) and bearing such distinguishing letters and numbers as such Canadian Lender may determine, but which at such time, except as otherwise
provided herein, has not been accepted by a Canadian Lender. 
 “Drawing” means an acceptance of completed Drafts by a
Canadian Lender or by any other Person pursuant to Section 2.04. 
 “Drawing Date” means any Business Day fixed
pursuant to Section 2.04(b) for a Drawing. 
 “Drawing Fee” means, with respect to the Drafts issued by
McKesson Canada hereunder and accepted as provided herein on any Drawing Date, an amount equal to the Drawing Fee Rate multiplied by the aggregate Face Amount of such Drafts, calculated, in each case, on the basis of the term to maturity of such
Draft and a year of 365 or 366 days, as the case may be (rounded to the nearest whole cent, with one-half of one cent being rounded up). 

“Drawing Fee Rate” means, in calculating the Drawing Fee for any Draft, the Applicable Rate for Bankers’ Acceptances.

 “Drawing Notice” has the meaning set forth in Section 2.04(b)(i). 

“Drawing Purchase Price” means, in respect of Drafts to be accepted by a Canadian Lender or any other Person, the difference
between (a) the result (rounded to the nearest whole cent, with one-half of one cent being rounded up) obtained by dividing the aggregate Face Amount of such Drafts by the sum of one plus the product of (i) the Effective Discount Rate
multiplied by (ii) a fraction the numerator of which is the term of maturity of such Drafts and the denominator of which is 365; and (b) the applicable Drawing Fee. 

  
 9 

 “Effective Discount Rate” means (a) with respect to any Bankers’
Acceptance accepted by a Canadian Lender named on Schedule I to the Bank Act (Canada), the rate determined by the Canadian Administrative Agent as being CDOR on the applicable Drawing Date, and (b) with respect to any Bankers’
Acceptance accepted by any other Canadian Lender, the lesser of (i) the rate advised by such Canadian Lender to the Canadian Administrative Agent as being the discount rate of such Canadian Lender, calculated on the basis of a year of 365 or
366 days, as applicable, and determined in accordance with normal market practice, for bankers’ acceptances of such Lender having comparable Face Amount and identical maturity date to the Face Amount and maturity date of such Bankers’
Acceptance and (ii) the rate determined by the Canadian Administrative Agent in accordance with clause (a) above plus 0.07% per annum. 

“Eligible Assignee” has the meaning specified in Section 11.06(g). 

“Environmental Laws” means any and all federal, state, provincial, municipal, local, and foreign statutes, laws, regulations,
ordinances, rules, judgments, orders, decrees, permits, concessions, grants, franchises, licenses, agreements or governmental restrictions relating to pollution and the protection of the environment or the release of any materials into the
environment, including those related to hazardous substances or wastes, air emissions and discharges to waste or public systems. 

“Environmental Liability” means any liability, contingent or otherwise (including any liability for damages, costs of
environmental remediation, fines or penalties), of the Company or any of its Subsidiaries directly or indirectly resulting from or based upon (a) violation of any Environmental Law, (b) the generation, use, handling, transportation,
storage, treatment or disposal of any Hazardous Materials, (c) exposure to any Hazardous Materials or (d) the release or threatened release of any Hazardous Materials into the environment. 

“ERISA” means the Employee Retirement Income Security Act of 1974. 

“ERISA Affiliate” means any trade or business (whether or not incorporated) under common control with the Company within the
meaning of Section 414(b) or (c) of the Code (and Sections 414(m) and (o) of the Code for purposes of provisions relating to Section 412 of the Code). 

“ERISA Event” means (a) a Reportable Event with respect to a Pension Plan; (b) a withdrawal by the Company or any
ERISA Affiliate from a Pension Plan subject to Section 4063 of ERISA during a plan year in which it was a substantial employer (as defined in Section 4001(a)(2) of ERISA) or a cessation of operations that is treated as such a withdrawal
under Section 4062(e) of ERISA; (c) a complete or partial withdrawal by the Company or any ERISA Affiliate from a Multiemployer Plan or notification that a Multiemployer Plan is in reorganization; (d) the filing of a notice of intent
to terminate, the treatment of a Plan amendment as a termination under Sections 4041 or 4041A of ERISA, or the commencement of proceedings by the PBGC to terminate a Pension Plan or Multiemployer Plan; (e) an event or condition which
constitutes grounds under Section 4042 of ERISA for the termination of, or the appointment of a trustee to administer, any Pension Plan or Multiemployer Plan; or (f) the imposition of any liability under Title IV of ERISA, other than for
PBGC premiums due but not delinquent under Section 4007 of ERISA, upon the Company or any ERISA Affiliate. 

“Eurodollar Base Rate” has the meaning specified in the definition of Eurodollar Rate. 

  
 10 

 “Eurodollar Rate” means 

(a) for any Interest Period with respect to any Eurodollar Rate Loan, a rate per annum determined by the Administrative Agent pursuant to
the following formula: 
  

					
	Eurodollar Rate = 	 	 Eurodollar Base Rate
	 	
		 	1.00 — Eurodollar Reserve Percentage	 	

 where, 

“Eurodollar Base Rate” means, for such Interest Period, the rate per annum equal to the British Bankers
Association LIBOR Rate (“BBA LIBOR”), as published by Reuters (or other commercially available source providing quotations of BBA LIBOR as designated by the Administrative Agent from time to time) at approximately 11:00 a.m. London
time two Business Days prior to the commencement of such Interest Period for deposits in the Applicable Currency (for delivery on the first day of such Interest Period) with a term equivalent to such Interest Period. If such rate is not available at
such time for any reason, then the “Eurodollar Base Rate” for such Interest Period shall be the rate per annum determined by the Administrative Agent to be the rate at which deposits in the Applicable Currency for delivery on the first day
of such Interest Period in same day funds in the approximate amount of the Eurodollar Rate Loan being made, continued or converted by Bank of America and with a term equivalent to such Interest Period would be offered by Bank of America’s
London Branch (or other Bank of America branch or Affiliate) to major banks in the London or other offshore interbank eurodollar market for such currency at their request at approximately 11:00 a.m. (London time) two Business Days prior to the
commencement of such Interest Period; and 
 (b) for any interest calculation with respect to a Base Rate Loan on any date, a rate per
annum determined by the Administrative Agent pursuant to the following formula: 
  

					
	Eurodollar Rate = 	 	 Eurodollar Base Rate
	 	
		 	1.00 — Eurodollar Reserve Percentage	 	

 where, 

“Eurodollar Base Rate” means the rate per annum equal to (i) BBA LIBOR, as published by Reuters (or such
other commercially available source providing quotations of BBA LIBOR as may be designated by the Administrative Agent from time to time) at approximately 11:00 a.m., London time, two Business Days prior to such date, for Dollar deposits with a term
of one month commencing on that day or, (ii) if such rate is not available at such time for any reason, the rate per annum determined by the Administrative Agent to be the rate at which deposits in Dollars for delivery on the date of
determination in same day funds in the approximate amount of the Base Rate Loan being made or maintained and with a term equal to one month would be offered by Bank of America’s London Branch to major banks in the London interbank eurodollar
market at their request at the date and time of determination. 
 “Eurodollar Rate Loan” means a Committed Loan that bears
interest at a rate based on clause (a) of the definition of “Eurodollar Rate.” 

  
 11 

 “Eurodollar Reserve Percentage” means, for any day during any Interest Period
(A) in the case of Domestic Loans, the reserve percentage (expressed as a decimal, carried out to five decimal places) in effect on such day, whether or not applicable to any Domestic Lender, under regulations issued from time to time by the
FRB for determining the maximum reserve requirement (including any emergency, supplemental or other marginal reserve requirement) with respect to Eurocurrency funding (currently referred to as “Eurocurrency liabilities”) and (B) in
the case of Canadian Loans, the reserve percentage (expressed as a decimal, carried out to five decimal places) in effect on such day, whether or not applicable to any Canadian Lender, under any applicable regulations of the central bank or other
relevant Governmental Authority in Canada. The Eurodollar Rate for each outstanding Eurodollar Rate Loan shall be adjusted automatically as of the effective date of any change in the Eurodollar Reserve Percentage. 

“Event of Default” has the meaning specified in Section 8.01. 

“Excluded Taxes” has the meaning specified in Section 3.01(a). 

“Existing Letters of Credit” means those letters of credit issued prior to the date hereof for the account of the Company or
one of its Subsidiaries, as identified by the L/C Issuer to the Administrative Agent in a writing confirmed by the Company on or prior to the date hereof. 

“Existing Maturity Date” has the meaning specified in Section 2.17. 

“Existing Revolving Credit Agreement” means that certain Amended and Restated Credit Agreement dated as of June 8, 2007
among the Company, McKesson Canada, Bank of America, as administrative agent, BA Canada, as Canadian administrative agent, Wachovia Bank, National Association, as L/C issuer, and the lenders from time to time party thereto, as amended to date. 

“Exposure” means, with respect to any Lender, (a) prior to the termination of the Commitment, such Lender’s
Commitment and (b) after the termination of the Commitment, the Total Outstandings for such Lender. 
 “Extending
Lender” has the meaning specified in Section 2.17. 
 “Face Amount” means, in respect of a Draft or a
Bankers’ Acceptance, as the case may be, the amount payable to the holder thereof on its maturity. 
 “FATCA” means
Sections 1471 through 1474 of the Code, as of the date of this Agreement, and any current or future regulations or official interpretations thereof. 

“Federal Funds Rate” means, for any day, the rate per annum equal to the weighted average of the rates on overnight Federal
funds transactions with members of the Federal Reserve System arranged by Federal funds brokers on such day, as published by the Federal Reserve Bank of New York on the Business Day next succeeding such day; provided that (a) if such day
is not a Business Day, the Federal Funds Rate for such day shall be such rate on such transactions on the next preceding Business Day as so published on the next succeeding Business Day, and (b) if no such rate is so published on such next
succeeding Business Day, the Federal Funds Rate for such day shall be the weighted average rate (rounded upward, if necessary, to a whole multiple of 1/100 of 1%) charged to Bank of America on such day on such transactions as determined by the
Administrative Agent. 
 “Fee Letter” means the letter agreement, dated September 8, 2011, among the Company, the
Administrative Agent and the Arranger. 

  
 12 

 “Fitch” means Fitch, Inc., a majority-owned subsidiary of Fimalac, S.A., and any
successor thereto. 
 “Foreign Lender” has the meaning specified in Section 11.14(a)(i). 

“FRB” means the Board of Governors of the Federal Reserve System of the United States. 

“Fronting Exposure” means, at any time there is a Defaulting Lender, such Defaulting Lender’s Pro Rata Share of the
outstanding L/C Obligations other than L/C Obligations as to which such Defaulting Lender’s participation obligation has been reallocated to other Lenders or Cash Collateralized in accordance with the terms hereof. 

“Fund” means any Person (other than a natural person) that is (or will be) engaged in making, purchasing, holding or
otherwise investing in commercial loans and similar extensions of credit in the ordinary course of its activities. 
 “FX Trading
Office” means the Foreign Exchange Trading Unit of Bank of America located in London, England, or such other of Bank of America’s offices as Bank of America may designate from time to time or, if Bank of America is no longer the
Administrative Agent, the offices of Administrative Agent as Administrative Agent may designate from time to time. 

“GAAP” means generally accepted accounting principles in the United States set forth in the opinions and pronouncements of
the Accounting Principles Board and the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or such other principles as may be approved by a significant segment of the
accounting profession in the United States, that are applicable to the circumstances as of the date of determination, consistently applied. 

“Governmental Authority” means any nation or government, any state or other political subdivision thereof, any agency,
authority, instrumentality, regulatory body, court, administrative tribunal, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to government. 

“Granting Lender” has the meaning specified in Section 11.06(h). 

“Guarantee” means, as to any Person, any (a) any obligation, contingent or otherwise, of such Person guaranteeing or
having the economic effect of guaranteeing any Indebtedness or other obligation payable or performable by another Person (the “primary obligor”) in any manner, whether directly or indirectly, and including any obligation of such Person,
direct or indirect, (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or other obligation, (ii) to purchase or lease property, securities or services for the purpose of assuring the
obligee in respect of such Indebtedness or other obligation of the payment or performance of such Indebtedness or other obligation, (iii) to maintain working capital, equity capital or any other financial statement condition or liquidity or
level of income or cash flow of the primary obligor so as to enable the primary obligor to pay such Indebtedness or other obligation, or (iv) entered into for the purpose of assuring in any other manner the obligee in respect of such
Indebtedness or other obligation of the payment or performance thereof or to protect such obligee against loss in respect thereof (in whole or in part), or (b) any Lien on any assets of such Person securing any Indebtedness or other obligation
of any other Person, whether or not such Indebtedness or other obligation is assumed by such Person. The amount of any Guarantee shall be deemed to be an amount equal to the stated or determinable amount of the related primary obligation, or portion
thereof, in respect of which such Guarantee is made or, if not stated or determinable, the maximum reasonably anticipated liability in respect thereof as determined by the guaranteeing Person in good faith. The term “Guarantee” as a verb
has a corresponding meaning. 

  
 13 

 “Guarantied Obligations” has the meaning set forth in Section 10.01.

 “Hazardous Materials” means all explosive or radioactive substances or wastes and all hazardous or toxic substances,
wastes or other pollutants, including petroleum or petroleum distillates, asbestos or asbestos-containing materials, polychlorinated biphenyls, radon gas, infectious or medical wastes and all other substances or wastes of any nature regulated
pursuant to any Environmental Law. 
 “Indebtedness” means, as to any Person at a particular time, without duplication, all
of the following: 
 (a) all obligations of such Person for borrowed money; 

(b) all obligations of such Person to pay the deferred purchase price of property or services (other than trade accounts payable in the
ordinary course of business); 
 (c) all non-contingent reimbursement or payment obligations of such Person arising under letters of credit
(including standby and commercial), bankers’ acceptances, bank guaranties, shipside bonds, surety bonds and similar instruments; 
 (d)
all obligations of such Person evidenced by bonds, debentures, notes, loan agreements or other similar instruments; 
 (e) capital leases
and Synthetic Lease Obligations; 
 (f) net obligations of such Person under any Swap Contract; 

(g) all indebtedness created or arising under any conditional sale or other title retention agreement, or incurred as financing, in either
case with respect to property acquired by the Person (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession or sale of such property); and 

(h) all indebtedness referred to in clauses (a) through (g) above (excluding prepaid interest thereon) secured by a Lien on
property owned or being purchased by such Person, whether or not such indebtedness shall have been assumed by such Person or is limited in recourse. 

For all purposes hereof, the Indebtedness of any Person shall include the Indebtedness of any partnership or joint venture (other than a joint
venture that is itself a corporation or limited liability company) in which such Person is a general partner or a joint venturer, unless such Indebtedness is expressly made non-recourse to such Person. The amount of any net obligation under any Swap
Contract on any date shall be deemed to be the Swap Termination Value thereof as of such date. The amount of any capital lease or Synthetic Lease Obligation as of any date shall be deemed to be the amount of Attributable Indebtedness in respect
thereof as of such date. 
 “Indemnified Liabilities” has the meaning set forth in Section 11.04. 

“Indemnitees” has the meaning set forth in Section 11.04. 

“Insolvency Proceeding” means (a) any case, action or proceeding before any court or other

  
 14 

 
Governmental Authority relating to bankruptcy, reorganization, insolvency, liquidation, receivership, dissolution, winding-up or relief of debtors, or (b) any general assignment for the
benefit of creditors, composition, marshalling of assets for creditors, or other similar arrangement in respect of its creditors generally or any substantial portion of its creditors; undertaken under any Debtor Relief Law. 

“Interest Payment Date” means, (a) as to any Loan other than a Base Rate Loan or a Canadian Prime Rate Loan, the last
day of each Interest Period applicable to such Loan and the Maturity Date; provided, however, that if any Interest Period for a Eurodollar Rate Loan exceeds three months, the respective dates that fall every three months after the beginning
of such Interest Period shall also be Interest Payment Dates; and (b) as to any Base Rate Loan or Canadian Prime Rate Loan, (i) the fifth Business Day following the end of each calendar quarter and (ii) the Maturity Date. 

“Interest Period” means, as to each Eurodollar Rate Loan, the period commencing on the date such Eurodollar Rate Loan is
disbursed or converted to or continued as a Eurodollar Rate Loan and ending on the date one, two, three or six months thereafter, as selected by the Applicable Borrower in its Committed Loan Notice; provided that: 

(a) any Interest Period that would otherwise end on a day that is not a Business Day shall be extended to the next succeeding Business Day
unless such Business Day falls in another calendar month, in which case such Interest Period shall end on the next preceding Business Day; 

(b) any Interest Period that begins on the last Business Day of a calendar month (or on a day for which there is no numerically corresponding
day in the calendar month at the end of such Interest Period) shall end on the last Business Day of the calendar month at the end of such Interest Period; and 

(c) no Interest Period shall extend beyond the Maturity Date. 

“IRS” means the United States Internal Revenue Service. 

“ISP” means, with respect to any Letter of Credit, the “International Standby Practices 1998” published by the
Institute of International Banking Law & Practice, Inc. (or such later version thereof as may be in effect at the time of issuance). 

“Issuer Documents” means with respect to any Letter of Credit, the Letter Credit Application, and any other document,
agreement and instrument entered into by the L/C Issuer and the applicable Domestic Borrower (or any Subsidiary) or in favor of the L/C Issuer and relating to any such Letter of Credit. 

“Laws” means, collectively, all international, foreign, Canadian, federal, state, provincial, municipal and local statutes,
treaties, rules, guidelines, regulations, ordinances, codes and administrative or judicial precedents or authorities, including the interpretation or administration thereof by any Governmental Authority charged with the enforcement, interpretation
or administration thereof, and all applicable administrative orders, directed duties, requests, licenses, authorizations and permits of, and agreements with, any Governmental Authority, in each case whether or not having the force of law. 

“L/C Advance” means, with respect to each Lender, such Lender’s funding of its participation in any L/C Borrowing in
accordance with its Pro Rata Share. 
 “L/C Borrowing” means an extension of credit resulting from a drawing under any
Letter of Credit which has not been reimbursed on the date when made or refinanced as a Borrowing. 

  
 15 

 “L/C Credit Extension” means, with respect to any Letter of Credit, the issuance
thereof or extension of the expiry date thereof, or the renewal or increase of the amount thereof. 
 “L/C Issuer” means
Wells Fargo Bank, National Association in its capacity as issuer of Letters of Credit hereunder, or any successor issuer of Letters of Credit hereunder. 

“L/C Obligations” means, as at any date of determination, the aggregate undrawn amount of all outstanding Letters of Credit
plus the aggregate of all Unreimbursed Amounts, including all L/C Borrowings. For purposes of computing the amount available to be drawn under any Letter of Credit, the amount of such Letter of Credit shall be determined in accordance with
Section 1.07. For all purposes of this Agreement, if on any date of determination a Letter of Credit has expired by its terms but any amount may still be drawn thereunder by reason of the operation of Rule 3.14 of the ISP, such Letter of
Credit shall be deemed to be “outstanding” in the amount so remaining available to be drawn. 
 “Lender” has the
meaning specified in the introductory paragraph hereto and, as the context requires, includes the L/C Issuer. 
 “Lending
Office” means, as to any Lender, the office or offices of such Lender described as its “Lending Office” or “Domestic Lending Office” or “Eurodollar Lending Office,” as the case may be, in such Lender’s
Administrative Questionnaire, or such other office or offices as a Lender may from time to time notify the Company and the Administrative Agent. 

“Letter of Credit” means (a) any letter of credit issued hereunder and (b) each of the Existing Letters of Credit.
A Letter of Credit may be a commercial letter of credit or a standby letter of credit. 
 “Letter of Credit Application”
means an application and agreement for the issuance or amendment of a Letter of Credit in the form from time to time in use by the L/C Issuer. 

“Letter of Credit Expiration Date” means the day that is five Business Days prior to the Maturity Date then in effect. 

“Letter of Credit Sublimit” means an amount equal to $500,000,000. The Letter of Credit Sublimit is part of, and not in
addition to, the Aggregate Commitments. 
 “Lien” means any mortgage, pledge, hypothecation, assignment, deposit
arrangement, encumbrance, lien (statutory or other), charge, or preference, priority or other security interest of any kind or nature whatsoever (including any conditional sale or other title retention agreement, and any financing lease having
substantially the same economic effect as any of the foregoing); provided that “Lien” shall not include (i) the interest of a lessor under an operating lease or (ii) the sale of accounts receivable. 

“Loan” means an extension of credit by a Lender to a Borrower under Article II in the form of a Committed Loan. 

“Loan Documents” means this Agreement, any joinder agreement delivered pursuant to Section 7.02(d), any Notes, any
Drafts, any Bankers’ Acceptances, the Fee Letter and all other documents delivered to the Administrative Agent, Canadian Administrative Agent or any Lender in connection herewith. 

“Loan Parties” means, collectively, the Borrowers. 

“Margin Stock” means “margin stock” as such term is defined in Regulation T, U or X of the FRB. 

  
 16 

 “Master Agreement” has the meaning set forth in the definition of “Swap
Contract.” 
 “Material Adverse Effect” means (a) a material adverse change in, or a material adverse effect
upon, the operations, business, properties or condition (financial or otherwise) of the Company and its Subsidiaries taken as a whole; (b) a material impairment of the ability of any Borrower to perform its obligations under any Loan Document
to which it is a party; or (c) a material adverse effect upon the legality, validity, binding effect or enforceability against any Borrower of any Loan Document to which it is a party. 

“Material Subsidiary” means, at any time, (a) McKesson Canada and (b) any other Subsidiary having at such time 10%
or more of the Company’s consolidated total (gross) revenues for the preceding four fiscal quarter period, as of the last day of the preceding fiscal quarter based upon the Company’s most recent annual or quarterly financial statements
delivered to the Administrative Agent under Section 6.01. 
 “Maturity Date” means the later of
(a) September 23, 2016 or (b) if the term of this Agreement is extended pursuant to Section 2.17, such extended termination date as determined pursuant to such Section; provided, however, that, in each case, if
such date is not a Business Day, the next preceding Business Day; provided further that with respect to any Non-Extending Lender, the Maturity Date of such Non-Extending Lender’s Commitment shall be the Existing Maturity Date
notwithstanding the extension of Commitments by any other Lender pursuant to Section 2.17. 
 “McKesson Canada”
has the meaning specified in the introductory paragraph hereto. 
 “Member” means a Canadian Lender that has entered into a
contract of membership with the Clearing House. 
 “Moody’s” means Moody’s Investors Service, Inc. and any
successor thereto. 
 “Multiemployer Plan” means any employee benefit plan of the type described in Section 4001(a)(3)
of ERISA, to which the Company or any ERISA Affiliate makes or is obligated to make contributions, or during the preceding five plan years, has made or been obligated to make contributions. 

“Net Worth” means (a) sum of (i) the capital stock, (ii) additional paid in capital, (iii) retained
earnings (or minus accumulated deficits) and (iv) accumulated other comprehensive income, minus (b) treasury stock, in each case, of the Company and its Subsidiaries determined on a consolidated basis in conformity with GAAP on such date.

 “Non-Extending Lender” has the meaning specified in Section 2.17. 

“Note” means a promissory note executed by a Borrower in favor of a Lender pursuant to Section 2.11,
substantially in the form of Exhibit B-1 with respect to Domestic Loans or substantially in the form of Exhibit B-2 with respect to Canadian Loans. 

“Notice Date” has the meaning specified in Section 2.17. 

“Obligations” means all advances to, and debts, liabilities, obligations, covenants and duties of, any Loan Party arising
under any Loan Document or otherwise with respect to any Loan, Draft, Bankers’ Acceptance or Letter of Credit, whether direct or indirect (including those acquired by assumption), 

  
 17 

 
absolute or contingent, due or to become due, now existing or hereafter arising and including interest and fees that accrue after the commencement by or against any Loan Party or any Affiliate
thereof of any proceeding under any Debtor Relief Laws naming such Person as the debtor in such proceeding, regardless of whether such interest and fees are allowed claims in such proceeding. 

“Organization Documents” means, with respect to (a) any corporation, the certificate or articles of incorporation and
the bylaws, (b) any limited liability company, the certificate of formation and limited liability company agreement or operating agreement, (c) any partnership, the certificate of formation and partnership agreement, and (d) any
organization incorporated or formed in any non-U.S. jurisdiction, constitutive documents with respect to such organization that are equivalent or comparable to the foregoing, as may be applicable. 

“Other Taxes” has the meaning specified in Section 3.01(b). 

“Outstanding Amount” means (a) with respect to Committed Loans and on any date, the aggregate outstanding principal
amount thereof after giving effect to any borrowings and prepayments or repayments of Committed Loans occurring on such date; (b) with respect to any Bankers’ Acceptances on any date, the amount of the Acceptance Usage on such date after
giving effect to any Bankers’ Acceptance Credit Extension occurring on such date and any other changes in the aggregate amount of the Acceptance Usage as of such date, including as a result of any reimbursements of outstanding unpaid drawings
under any Bankers’ Acceptance or any reductions in the maximum amount available for drawing under Bankers’ Acceptance taking effect on such date; and (c) with respect to any L/C Obligations on any date, the amount of such L/C
Obligations on such date after giving effect to any L/C Credit Extension occurring on such date and any other changes in the aggregate amount of the L/C Obligations as of such date, including as a result of any reimbursements of outstanding unpaid
drawings under any Letters of Credit or any reductions in the maximum amount available for drawing under Letters of Credit taking effect on such date. 

“Overnight Canadian Rate” means, for any day, the rate of interest per annum at which overnight deposits in Canadian Dollars,
in an amount approximately equal to the amount with respect to which such rate is being determined, would be offered for such day by the Administrative Agent’s London Branch to major banks in the London or other applicable offshore interbank
market. 
 “Participant” has the meaning specified in Section 11.06(d)(i). 

“Participant Register” has the meaning specified in Section 11.06(d)(ii). 

“Participation Funding Date” has the meaning specified in Section 2.01(b)(ii)(A). 

“PBGC” means the Pension Benefit Guaranty Corporation. 

“Pension Plan” means any “employee pension benefit plan” (as such term is defined in Section 3(2) of ERISA),
other than a Multiemployer Plan, that is subject to Title IV of ERISA and is sponsored or maintained by the Company or any ERISA Affiliate or to which the Company or any ERISA Affiliate contributes or has an obligation to contribute, or in the case
of a multiple employer or other plan described in Section 4064(a) of ERISA, has made contributions at any time during the immediately preceding five plan years. 

“Person” means any natural person, corporation, limited liability company, trust, joint venture, association, company,
partnership, Governmental Authority or other entity. 

  
 18 

 “Plan” means any “employee benefit plan” (as such term is defined in
Section 3(3) of ERISA) established by any Borrower or, with respect to any such plan that is subject to Section 412 of the Code or Title IV of ERISA, any ERISA Affiliate. 

“Pro Rata Share” means, with respect to each Lender at any time, a fraction (expressed as a percentage, carried out to the
ninth decimal place), the numerator of which is the amount of the Commitment of such Lender at such time and the denominator of which is the amount of the Aggregate Commitments at such time; provided that if the Commitment of each Lender to
make Loans, the obligation of the Canadian Lenders to make Bankers’ Acceptance Credit Extensions and the obligation of the L/C Issuer to make L/C Credit Extensions have been terminated pursuant to Section 8.02 or if the Aggregate
Commitments have expired, then the Pro Rata Share of each Lender shall be determined based on the Pro Rata Share of such Lender immediately prior to such termination and after giving effect to any subsequent assignments made pursuant to the terms
hereof. The initial Pro Rata Share of each Lender is set forth opposite the name of such Lender on Schedule 2.01 or in the Assignment and Assumption pursuant to which such Lender becomes a party hereto, as applicable. 

“Proceedings” has the meaning set forth in Section 6.03(c). 

“Qualified Receivables Transaction” mean any transaction or series of transactions entered into by the Company or any of its
Subsidiaries pursuant to which the Company or any of its Subsidiaries sells, conveys or otherwise transfers to (i) a Receivables Subsidiary (in the case of a transfer by the Company or any of its Subsidiaries) and (ii) any other Person (in
the case of a transfer by a Receivables Subsidiary), or grants a security interest in (all of the following constituting “Receivables Program Assets”), any accounts receivable (whether now existing or arising in the future) or
inventory of the Company or any of its Subsidiaries, and any assets related thereto including, without limitation, all collateral securing such accounts receivable, all contracts and all guarantees or other obligations in respect of such accounts
receivable or inventory, proceeds of such accounts receivable and other assets which are customarily transferred or in respect of which security interests are customarily granted in connection with asset securitization transactions involving
accounts receivable or inventory. 
 “Receivables Subsidiary” means a Subsidiary of the Company which engages in no
activities other than in connection with the financing of accounts receivable or inventory (a) no portion of the Indebtedness or any other obligations (contingent or otherwise) of which (i) is guaranteed by the Company or any Subsidiary of
the Company (excluding guarantees of obligations (other than the principal of, and interest on, Indebtedness) pursuant to representations, warranties, covenants and indemnities entered into in the ordinary course of business in connection with a
Qualified Receivables Transaction), (ii) is recourse or obligates the Company or any Subsidiary of the Company in any way other than pursuant to representations, warranties, covenants and indemnities entered into in the ordinary course of
business in connection with a Qualified Receivables Transaction or (iii) subjects any property or asset of the Company or any Subsidiary of the Company (other than accounts receivable or inventory and related assets as provided in the
definition of “Qualified Receivables Transaction”), directly or indirectly, contingently or otherwise, to the satisfaction thereof, other than pursuant to representations, warranties, covenants and indemnities entered into in the ordinary
course of business in connection with a Qualified Receivables Transaction, (b) with which neither the Company nor any Subsidiary of the Company has any material contract, agreement, arrangement or understanding other than on terms customary for
securitization of receivables or inventory and (c) with which neither the Company nor any Subsidiary of the Company has any obligations to maintain or preserve such Subsidiary’s financial condition or cause such Subsidiary to achieve
certain levels of operating results. CGSF Funding Corporation, a Delaware corporation, shall be deemed a Receivables Subsidiary. 

“Register” has the meaning set forth in Section 11.06(c). 

  
 19 

 “Related Parties” means, with respect to any Person, such Person’s
Affiliates and the partners, directors, officers, employees, agents and advisors of such Person and of such Person’s Affiliates. 

“Relevant Obligation” has the meaning set forth in Section 8.01(e). 

“Reportable Event” means any of the events set forth in Section 4043(c) of ERISA, other than events for which the 30 day
notice period has been waived. 
 “Request for Credit Extension” means (a) with respect to a Borrowing, conversion or
continuation of Committed Loans, a Committed Loan Notice, (b) with respect to a Bankers’ Acceptance, a Drawing Notice and (c) with respect to an L/C Credit Extension, a Letter of Credit Application. 

“Request Period” has the meaning specified in Section 2.17. 

“Required Lenders” means, as of any date of determination, Lenders having more than 50% of the Aggregate Commitments or, if
the Commitment of each Lender to make Loans, the obligation of each Canadian Lender to make Bankers’ Acceptance Credit Extensions and the obligation of the L/C Issuer to make L/C Credit Extensions have been terminated pursuant to
Section 8.02, Lenders holding in the aggregate more than 50% of the Total Outstandings (with the aggregate amount of each Lender’s risk participation and funded participation in Bankers’ Acceptances and L/C Obligations being
deemed “held” by such Lender for purposes of this definition); provided that the Commitment of, and the portion of the Total Outstandings held or deemed held by, any Defaulting Lender shall be excluded for purposes of making a
determination of Required Lenders. 
 “Requirement of Law” means, as to any Person, any law (statutory or common), treaty,
rule or regulation or determination, decree or order of an arbitrator or of a Governmental 
 Authority, in each case applicable to or
binding upon the Person or any of its property or to which the Person or any of its property is subject, including but not limited to any Environmental Law. 

“Response Deadline” has the meaning specified in Section 2.17. 

“Responsible Officer” means the chief executive officer, president, chief financial officer, corporate vice president or the
treasurer of a Loan Party. Any document delivered hereunder that is signed by a Responsible Officer of a Loan Party shall be conclusively presumed to have been authorized by all necessary corporate, partnership and/or other action on the part of
such Loan Party and such Responsible Officer shall be conclusively presumed to have acted on behalf of such Loan Party. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc. and any
successor thereto. 
 “SEC” means the Securities and Exchange Commission, or any Governmental Authority succeeding to any
of its principal functions. 
 “SPC” has the meaning specified in Section 11.06(h). 

“Subsidiary” of a Person means a corporation, partnership, joint venture, limited liability company, unlimited liability
company or other business entity of which a majority of the shares of securities or other interests having ordinary voting power for the election of directors or other governing body (other than securities or interests having such power only by
reason of the happening of a contingency) are at the time beneficially owned, or the management of which is otherwise controlled, directly, or indirectly through one or more intermediaries, or both, by such Person. Unless otherwise specified, all
references herein to a “Subsidiary” or to “Subsidiaries” shall refer to a Subsidiary or Subsidiaries of the Company. 

  
 20 

 “Swap Contract” means (a) any and all rate swap transactions, basis swaps,
credit derivative transactions, forward rate transactions, commodity swaps, commodity options, forward commodity contracts, equity or equity index swaps or options, bond or bond price or bond index swaps or options or forward bond or forward bond
price or forward bond index transactions, interest rate options, forward foreign exchange transactions, cap transactions, floor transactions, collar transactions, currency swap transactions, cross-currency rate swap transactions, currency options,
spot contracts, or any other similar transactions or any combination of any of the foregoing (including any options to enter into any of the foregoing), whether or not any such transaction is governed by or subject to any master agreement, and
(b) any and all transactions of any kind (other than Eligible ASRs, as defined below), and the related confirmations, which are subject to the terms and conditions of, or governed by, any form of master agreement published by the International
Swaps and Derivatives Association, Inc., any International Foreign Exchange Master Agreement, or any other master agreement relating to any of the foregoing (any such master agreement, together with any related schedules, a “Master
Agreement”), including any such obligations or liabilities under any Master Agreement (other than Eligible ASRs). “Eligible ASR” shall mean any accelerated share repurchase documented under a Master Agreement. 

“Swap Termination Value” means, in respect of any one or more Swap Contracts, after taking into account the effect of any
legally enforceable netting agreement relating to such Swap Contracts, (a) for any date on or after the date such Swap Contracts have been closed out and termination value(s) determined in accordance therewith, such termination value(s), and
(b) for any date prior to the date referenced in clause (a), the amount(s) determined as the mark-to-market value(s) for such Swap Contracts, as determined based upon one or more mid-market or other readily available quotations provided by any
recognized dealer in such Swap Contracts (which may include a Lender or any Affiliate of a Lender). 
 “Synthetic Lease
Obligation” means the monetary obligation of a Person under (a) a so-called synthetic, off-balance sheet or tax retention lease, or (b) an agreement for the use or possession of property creating obligations that do not appear on
the balance sheet of such Person but which, upon the insolvency or bankruptcy of such Person, would be characterized as the indebtedness of such Person (without regard to accounting treatment). 

“Taxes” has the meaning specified in Section 3.01(a). 

“Total Canadian Outstandings” means (a) as to all Lenders at any date of determination, the sum of (i) the
aggregate principal amount of all outstanding Canadian Loans plus (ii) the Acceptance Usage, in each case valued in Dollar Equivalents, and (b) as to any Canadian Lender at any date of determination, the sum of (x) the aggregate
principal amount of all outstanding Canadian Loans made by such Canadian Lender or its Affiliate plus (y) the Acceptance Usage of such Canadian Lender or its Affiliate, in each case valued in Dollar Equivalents. 

“Total Capitalization” means, on any date, the sum of (a) Total Debt and (b) the Net Worth on such date. 

“Total Debt” means, on any date, the difference of (a) all Indebtedness of the Company and its Subsidiaries determined
on a consolidated basis on such date, minus (b) Indebtedness incurred by any Receivables Subsidiary in connection with a Qualified Receivables Transaction. 

  
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 “Total Outstandings” means (a) as to all Lenders at any date of
determination, the sum of (i) the Outstanding Amount of all Loans and L/C Obligations plus (ii) the Acceptance Usage, in each case valued in Dollar Equivalents, and (b) as to any Lender at any date of determination, the sum of
(x) the Outstanding Amount of all Loans and L/C Obligations of such Lender or its Affiliate plus (y) the Acceptance Usage of such Lender or its Affiliate, in each case valued in Dollar Equivalents. 

“Type” means (a) with respect to a Domestic Loan, its character as a Base Rate Loan or a Eurodollar Rate Loan and
(b) with respect to a Canadian Loan, its character as a Canadian Prime Rate Loan or a Eurodollar Rate Loan. 
 “Unfunded
Pension Liability” means the excess of a Pension Plan’s benefit liabilities under Section 4001(a)(16) of ERISA, over the current value of that Pension Plan’s assets, determined in accordance with the assumptions used for
funding the Pension Plan pursuant to Section 412 of the Code for the applicable plan year. 
 “United States” and
“U.S.” mean the United States of America. 
 “Unreimbursed Amount” has the meaning set forth in
Section 2.03(c)(i). 
 “Wholly-Owned Subsidiary” means any Subsidiary in which (other than directors’
qualifying shares required by law) 100% of the capital stock of each class or other interests having ordinary voting power, and 100% of the capital stock of every other class or other interests, in each case, at the time as of which any
determination is being made, is owned, beneficially and of record, by the Company, or by one or more of the other Wholly-Owned Subsidiaries, or both. 

1.02 Other Interpretive Provisions. With reference to this Agreement and each other Loan Document, unless otherwise specified herein or in such other
Loan Document: 
 (a) The meanings of defined terms are equally applicable to the singular and plural forms of the defined terms. 

(b)(i) The words “herein,” “hereto,” “hereof” and “hereunder” and words of
similar import when used in any Loan Document shall refer to such Loan Document as a whole and not to any particular provision thereof. 

(ii) Article, Section, Exhibit and Schedule references are to the Loan Document in which such reference appears.

 (iii) The term “including” is by way of example and not limitation. 

(iv) The term “documents” includes any and all instruments, documents, agreements, certificates, notices, reports, financial
statements and other writings, however evidenced, whether in physical or electronic form. 
 (c) In the computation of periods of time from
a specified date to a later specified date, the word “from” means “from and including”; the words “to” and “until” each mean “to but excluding;” and the word
“through” means “to and including”. 

  
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 (d) Section headings herein and in the other Loan Documents are included for convenience of
reference only and shall not affect the interpretation of this Agreement or any other Loan Document. 
 1.03 Accounting Terms. (a) All
accounting terms not specifically or completely defined herein shall be construed in conformity with, and all financial data (including financial ratios and other financial calculations) required to be submitted pursuant to this Agreement shall be
prepared in conformity with, GAAP applied on a consistent basis, as in effect from time to time, applied in a manner consistent with that used in preparing the Audited Financial Statements, except as otherwise specifically prescribed herein.

 (b) If at any time any change in GAAP would affect the computation of any financial ratio or requirement set forth in any Loan Document,
and either the Company or the Required Lenders shall so request, the Administrative Agent, the Lenders and the Company shall negotiate in good faith to amend such ratio or requirement to preserve the original intent thereof in light of such change
in GAAP (subject to the approval of the Required Lenders); provided that, until so amended, (i) such ratio or requirement shall continue to be computed in accordance with GAAP prior to such change therein and (ii) the Company shall
provide to the Administrative Agent and the Lenders financial statements and other documents required under this Agreement or as reasonably requested hereunder setting forth a reconciliation between calculations of such ratio or requirement made
before and after giving effect to such change in GAAP. 
 (c) If the Company shall elect as of the end of any financial reporting period to
prepare financial statements in accordance with International Financial Reporting Standards, as published by the International Accounting Standards Board (“IFRS”), rather than GAAP, then, following delivery to Administrative Agent
of a completed Compliance Certificate attaching the information required to be delivered for such financial reporting period, the parties hereto shall use their best efforts to amend (in a manner mutually satisfactory to Lenders and Borrowers) the
thresholds or methods of calculation of any financial ratio or requirement set forth in any Loan Document such that compliance therewith is neither more nor less burdensome (as determined by the Required Lenders in their sole discretion) to
Borrowers as a result of such conversion to IFRS and, thereafter, all references in the Loan Documents to GAAP shall be deemed references to IFRS. 

(d) All references herein to consolidated financial statements of the Borrower and its Subsidiaries or to the determination of any amount for
the Borrower and its Subsidiaries on a consolidated basis or any similar reference shall, in each case, be deemed to include each variable interest entity that the Borrower is required to consolidate pursuant to FASB ASC 810 as if such variable
interest entity were a Subsidiary as defined herein. 
 1.04 Rounding. Any financial ratios required to be maintained by the Company pursuant to this
Agreement shall be calculated by dividing the appropriate component by the other component, carrying the result to one place more than the number of places by which such ratio is expressed herein and rounding the result up or down to the nearest
number (with a rounding-up if there is no nearest number). 
 1.05 References to Agreements and Laws. Unless otherwise expressly provided herein,
(a) references to Organization Documents, agreements (including the Loan Documents) and other contractual instruments shall be deemed to include all subsequent amendments, restatements, extensions,

  
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supplements and other modifications thereto, but only to the extent that such amendments, restatements, extensions, supplements and other modifications are not prohibited by any Loan Document;
and (b) references to any Law shall include all statutory and regulatory provisions consolidating, amending, replacing, supplementing or interpreting such Law. 

1.06 Times of Day. Unless otherwise specified, all references herein to times of day shall be references to Pacific time (daylight or standard, as
applicable). 
 1.07 Letter of Credit Amounts. Unless otherwise specified herein, the amount of a Letter of Credit at any time shall be deemed to be
the stated amount of such Letter of Credit in effect at such time; provided, however, that with respect to any Letter of Credit that, by its terms or the terms of any Issuer Document related thereto, provides for one or more automatic
increases in the stated amount thereof, the amount of such Letter of Credit shall be deemed to be the maximum stated amount of such Letter of Credit after giving effect to all such increases, whether or not such maximum stated amount is in effect at
such time. 
 ARTICLE II 

THE COMMITMENTS AND CREDIT EXTENSIONS 

2.01 Committed Loans. 
 (a) Subject to
the terms and conditions set forth herein, each Lender severally agrees to make Domestic Loans to the Domestic Borrowers from time to time, on any Business Day during the Availability Period, in an aggregate amount not to exceed at any time
outstanding the amount of such Lender’s Commitment; provided, however, that after giving effect to any Borrowing, (i) the Total Outstandings shall not exceed the Aggregate Commitments, and (ii) the aggregate Outstanding Amount
of the Committed Loans of any Lender, plus such Lender’s Pro Rata Share of the Outstanding Amount of all L/C Obligations and all Bankers’ Acceptances (taking into account any Canadian Participations when determining the Total
Canadian Outstandings of a Canadian Lender) shall not exceed such Lender’s Commitment. Within the limits of each Lender’s Commitment, and subject to the other terms and conditions hereof, the Domestic Borrowers may borrow under this
Section 2.01(a), prepay under Section 2.05, and reborrow under this Section 2.01(a). Domestic Loans may be Base Rate Loans or Eurodollar Rate Loans, as further provided herein. 

(b)(i) Subject to the terms and conditions set forth herein, each Canadian Lender severally agrees to make Canadian Loans to McKesson Canada
from time to time, on any Business Day during the Availability Period, in an aggregate amount not to exceed at any time outstanding the amount of such Lender’s Canadian Commitment; provided, however, that, after giving effect to any
Borrowing under the Canadian Commitments, (A) the Total Outstandings shall not exceed the Aggregate Commitments, (B) the Total Canadian Outstandings shall not exceed the Aggregate Canadian Commitments, (C) McKesson Canada shall be a
Wholly-Owned Subsidiary, (D) the aggregate Outstanding Amount of the Canadian Loans of any Canadian Lender, plus such Lender’s Pro Rata Share of the Acceptance Usage (taking into account any Canadian Participations when determining the
Total Canadian Outstandings of a Canadian Lender) shall not exceed its Canadian Commitment, and (E) all Canadian Loans to McKesson Canada shall be made by the Canadian Lenders, shall be denominated and payable in Canadian Dollars and no other
currency and shall not be Base Rate Loans. Within the limits of each 

  
 24 

 
Lender’s Canadian Commitment, and subject to the other terms and conditions hereof, McKesson Canada may borrow under this Section 2.01(b)(i), prepay under
Section 2.05 and reborrow under this Section 2.01(b)(i). Canadian Loans may be Canadian Prime Rate Loans or Eurodollar Rate Loans, as provided herein. 

(ii)(A) Subject to Section 2.01(b)(ii)(B) below, on the Participation Funding Date (as defined below) each Lender that is not a
Canadian Lender shall be deemed to have purchased, and hereby agrees to purchase, a participation in each outstanding Canadian Loan and Bankers’ Acceptance Credit Extension in an amount equal to its Pro Rata Share of the unpaid amount of such
Canadian Loan or Bankers’ Acceptance Credit Extension together with accrued interest thereon (each, a “Canadian Participation”), such Canadian Participation to be governed by this Section 2.01(b)(ii)(A) and not by
Section 11.06(d) hereof. Only upon demand from any Canadian Lender on or after the date of (X) any Event of Default under Sections 8.01(a), 8.01(f) or 8.01(g) or (Y) an acceleration of the maturity pursuant
to Section 8.02(b) of any amounts owing to the Canadian Lenders under this Agreement (the date of such demand, the “Participation Funding Date”), each such Lender that has purchased a Canadian Participation (each a
“Canadian Participant”) shall deliver to the Canadian Administrative Agent an amount equal to its Canadian Participation in same day funds and in Canadian Dollars at the Canadian Administrative Agent’s Office for distribution
to Canadian Lenders in accordance with their Canadian Pro Rata Share. If any amount required to be paid by any Canadian Participant pursuant to this Section 2.01(b)(ii)(A) is not paid to the Canadian Administrative Agent when due but is
paid within three Business Days after the date such payment is due, such Canadian Participant shall pay to the Canadian Administrative Agent for distribution to Canadian Lenders on demand an amount equal to the product of (i) such amount, times
(ii) the Overnight Canadian Rate, times (iii) a fraction the numerator of which is the number of days that elapse during such period and the denominator of which is 365 or 366, as the case may be. If such amount required to be paid by any
Canadian Participant pursuant to this Section 2.01(b)(ii)(A) is not in fact made available to the Canadian Administrative Agent within three Business Days after the date such payment is due, the Canadian Administrative Agent shall be
entitled to recover from such Canadian Participant, on demand, such amount with interest thereon calculated from such due date at the rate per annum equal to the rate applicable thereto in accordance with the preceding sentence plus the Applicable
Rate. A certificate of the Canadian Administrative Agent submitted to any Canadian Participant with respect to any amounts owing under this Section 2.01(b)(ii)(A) shall be conclusive in the absence of manifest error. In the event the
Canadian Administrative Agent receives a payment with respect to any Canadian Loan in which Canadian Participations have been purchased and as to which the purchase price has been requested by the Canadian Administrative Agent and delivered by a
Canadian Participant as in this Section 2.01(b)(ii)(A) provided, the Canadian Administrative Agent shall promptly distribute to such Canadian Participant its share of such payment based on its Canadian Participation. If the Canadian
Administrative Agent pays any amount to a Canadian Participant pursuant to this Section 2.01(b)(ii)(A) in the belief or expectation that a related payment has been or will be received or collected and such related payment is not received
or collected by the Canadian Administrative Agent, then such Canadian Participant will promptly on demand by the Canadian Administrative Agent return such amount to the Canadian Administrative Agent, together with interest thereon at such rate as
the Canadian Administrative Agent shall determine to be customary between banks for correction of errors. If the Canadian Administrative Agent determines at any time that any amount received or collected by the Canadian Administrative Agent pursuant
to this 

  
 25 

 
Agreement is to be returned to McKesson Canada under this Agreement or paid to any other Person or entity pursuant to any Debtor Relief Laws, any sharing clause in this Agreement, or otherwise,
then, notwithstanding any other provision of this Agreement, the Canadian Administrative Agent shall not be required to distribute any portion thereof to any Canadian Participant, and each such Canadian Participant will promptly on demand by the
Canadian Administrative Agent repay any portion that the Canadian Administrative Agent shall have distributed to such Canadian Participant, together with interest thereon at such rate, if any, as the Canadian Administrative Agent shall pay to
McKesson Canada or such other Person or entity with respect thereto. If any amounts returned to McKesson Canada or reimbursed by a Canadian Participant pursuant to this Section 2.01(b)(ii)(A) are later recovered by the Canadian
Administrative Agent, the Canadian Administrative Agent shall promptly pay to each Canadian Participant a proportionate share based on such Canadian Participant’s Canadian Participation. 

(B) Notwithstanding any other provision of this Agreement, each Lender agrees that, prior to the Participation Funding Date, all amounts paid
or credited by McKesson Canada under this Agreement to a Canadian Lender shall be received by such Canadian Lender (a) for its own benefit and account or (b) as agent for or for the account of an Eligible Assignee that is a Canadian
Resident in respect of the Canadian Loans, and not otherwise as agent for or on behalf of any other Person. 
 2.02 Borrowings, Conversions and
Continuations of Committed Loans. 
 (a) With respect to Domestic Loans, each Borrowing, each conversion of Committed Loans from one
Type to the other, and each continuation of Eurodollar Rate Loans shall be made upon the applicable Domestic Borrower’s irrevocable notice to the Administrative Agent, which may be given by telephone. Each such notice must be received by the
Administrative Agent not later than 9:00 a.m. (i) three Business Days prior to the requested date of any Borrowing of, conversion to or continuation of Eurodollar Rate Loans or of any conversion of Eurodollar Rate Loans to Base Rate Committed
Loans, and (ii) on the requested date of any Borrowing of Base Rate Committed Loans. With respect to Canadian Loans, each Borrowing, each conversion of Canadian Loans from one Type to the other and each continuation of Eurodollar Rate Loans
shall be made upon McKesson Canada’s irrevocable notice to the Canadian Administrative Agent, which may be given by telephone. Each such notice must be received by the Canadian Administrative Agent not later than 11:00 a.m. (Eastern time)
(i) three Business Days prior to the requested date of any Borrowing of, conversion to or continuation of Eurodollar Rate Loans or of any conversion of Eurodollar Rate Loans to Canadian Prime Rate Loans, and (ii) one Business Day prior to
the requested date of any Borrowing of Canadian Prime Rate Loans. Each telephonic notice by a Borrower pursuant to this Section 2.02(a) must be confirmed promptly by delivery to the Applicable Agent of a written Committed Loan Notice,
appropriately completed and signed by a Responsible Officer of the Applicable Borrower. Each Borrowing, conversion or continuation of Domestic Loans shall be in a principal amount of $5,000,000 or a whole multiple of $1,000,000 in excess thereof
and, in the case of Canadian Loans, in an aggregate minimum amount of Cdn.$5,000,000 or any whole multiple of Cdn.$1,000,000 in excess thereof. Except as provided in Section 2.03(c) and 2.04(g), each Committed Loan Notice (whether
telephonic or written) shall specify (i) whether the Applicable Borrower is requesting a Borrowing, a conversion of Committed Loans from one Type to the other, or a continuation of Eurodollar Rate Loans, (ii) the identity of the Borrower
and the requested date of the Borrowing, 

  
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conversion or continuation, as the case may be (which shall be a Business Day), (iii) the principal amount of Committed Loans to be borrowed, converted or continued, (iv) the Type of
Committed Loans to be borrowed or to which existing Committed Loans are to be converted, (v) if applicable, the duration of the Interest Period with respect thereto and (vi) the Applicable Currency. If the Applicable Borrower fails to
specify a Type of Committed Loan in a Committed Loan Notice or if the Applicable Borrower fails to give a timely notice requesting a conversion or continuation, then the applicable Committed Loans shall be made as, or converted to, Base Rate Loans
or Canadian Prime Rate Loans, as appropriate. Any such automatic conversion to Base Rate Loans or Canadian Prime Rate Loans shall be effective as of the last day of the Interest Period then in effect with respect to the applicable Eurodollar Rate
Loans. If the Applicable Borrower requests a Borrowing of, conversion to, or continuation of Eurodollar Rate Loans in any such Committed Loan Notice, but fails to specify an Interest Period, they will be deemed to have specified an Interest Period
of one month. 
 (b) Following receipt of a Committed Loan Notice for Domestic Loans, the Administrative Agent shall promptly notify each
Lender of the amount of its Pro Rata Share of the applicable Domestic Loans, and if no timely notice of a conversion or continuation is provided by the applicable Domestic Borrower, the Administrative Agent shall notify each Lender of the details of
any automatic conversion to Base Rate Loans described in Section 2.02(a). Following receipt of a Committed Loan Notice for Canadian Loans, the Canadian Administrative Agent shall promptly notify each Canadian Lender of the amount of its
Canadian Pro Rata Share of the applicable Canadian Loans, and if no timely notice of a conversion or continuation is provided by the Borrowers, the Canadian Administrative Agent shall notify each Canadian Lender of the details of any automatic
conversion to Canadian Prime Rate Loans described in Section 2.02(a). In the case of a Borrowing, each Lender shall make the amount of its Domestic Loan available to the Administrative Agent in immediately available funds at the
Administrative Agent’s Office not later than 11:00 a.m., and each Canadian Lender will make the amount of its Canadian Loan available to the Canadian Administrative Agent in Canadian Dollars at the Canadian Administrative Agent’s Office by
11:00 a.m. (Eastern time) on the Business Day specified in the applicable Committed Loan Notice. Upon satisfaction of the applicable conditions set forth in Section 4.02 (and, if such Borrowing is the initial Credit Extension,
Section 4.01), the Applicable Agent shall make all funds so received available to the Applicable Borrower in like funds as received by the Applicable Agent either by (i) crediting the account of the Applicable Borrower on the books
of Bank of America or BA Canada with the amount of such funds or (ii) wire transfer of such funds, in each case in accordance with instructions provided to (and reasonably acceptable to) the Applicable Agent by the Applicable Borrower;
provided, however, that if, on the date the Committed Loan Notice with respect to such Borrowing is given by a Borrower, there are unpaid amounts due in respect of Bankers’ Acceptances, in the case of McKesson Canada, or L/C Borrowings
outstanding, in the case of the Domestic Borrowers, then the proceeds of such Borrowing shall be applied, first, to the payment in full of any such unpaid amounts and L/C Borrowings, and second, to the Applicable Borrower as provided
above. 
 (c) Except as otherwise provided herein, a Eurodollar Rate Loan may be continued or converted only on the last day of an Interest
Period for such Eurodollar Rate Loan. During the existence of a Default, no Loans may be requested as, converted to or continued as Eurodollar Rate Loans without the consent of the Required Lenders. 

  
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 (d) The Administrative Agent shall promptly notify the Applicable Borrower and the Lenders of the
interest rate applicable to any Interest Period for Eurodollar Rate Loans upon determination of such interest rate. The determination of the Eurodollar Rate by the Administrative Agent shall be conclusive in the absence of manifest error. At any
time that Base Rate Loans are outstanding, the Administrative Agent shall notify the Domestic Borrowers and the Lenders of any change in Bank of America’s prime rate used in determining the Base Rate promptly following the public announcement
of such change. At any time that Canadian Prime Rate Loans are outstanding, the Canadian Administrative Agent shall notify McKesson Canada and the Canadian Lenders of any change in BA Canada’s prime lending rate used in determining the Canadian
Prime Rate promptly following the public announcement of such change. 
 (e) After giving effect to all Borrowings, all conversions of
Committed Loans from one Type to the other, and all continuations of Committed Loans as the same Type, there shall not be more than ten Interest Periods in effect at any time with respect to Committed Loans. 

(f) The Dollar Equivalent amount of any Borrowing in Canadian Dollars will be determined by the Canadian Administrative Agent for such
Borrowing on the Computation Date therefor in accordance with Section 2.16(a) and shall be conclusive absent manifest error. 
 2.03 Letters
of Credit. 
 (a) The Letter of Credit Commitment. 

(i) Subject to the terms and conditions set forth herein, (A) the L/C Issuer agrees, in reliance upon the agreements of the Lenders set
forth in this Section 2.03, (1) from time to time on any Business Day during the period from the date hereof until the Letter of Credit Expiration Date, to issue Letters of Credit for the account of the Domestic Borrowers or certain
Subsidiaries, and to amend or extend Letters of Credit previously issued by it, in accordance with Section 2.03(b), and (2) to honor drafts under the Letters of Credit; and (B) the Lenders severally agree to participate in
Letters of Credit issued for the account of the Domestic Borrowers; provided that after giving effect to any L/C Credit Extension with respect to any Letter of Credit (x) the Total Outstandings shall not exceed the Aggregate Commitments,
(y) the aggregate Outstanding Amount of the Committed Loans of any Lender, plus such Lender’s Pro Rata Share of the Outstanding Amount of all L/C Obligations, shall not exceed such Lender’s Commitment, and (z) the
Outstanding Amount of the L/C Obligations shall not exceed the Letter of Credit Sublimit. Within the foregoing limits, and subject to the terms and conditions hereof, each Domestic Borrower’s ability to obtain Letters of Credit shall be fully
revolving, and accordingly each Domestic Borrower may, during the foregoing period, obtain Letters of Credit to replace Letters of Credit that have expired or that have been drawn upon and reimbursed. 

(ii) The L/C Issuer shall be under no obligation to issue any Letter of Credit if: 

(A) any order, judgment or decree of any Governmental Authority or arbitrator shall by its terms purport to enjoin or restrain the L/C Issuer
from issuing such Letter of Credit, or any Law applicable to the L/C Issuer or any request or directive (whether or not having the force of law) from any Governmental Authority with jurisdiction over the L/C Issuer shall prohibit, or request that
the L/C Issuer refrain from, the issuance of letters of credit 

  
 28 

 
generally or such Letter of Credit in particular or shall impose upon the L/C Issuer with respect to such Letter of Credit any restriction, reserve or capital requirement (for which the L/C
Issuer is not otherwise compensated hereunder) not in effect on the date hereof, or shall impose upon the L/C Issuer any unreimbursed loss, cost or expense which was not applicable on the date hereof and which the L/C Issuer in good faith deems
material to it; 
 (B) the issuance of such Letter of Credit would violate one or more policies of the L/C Issuer applicable to letters of
credit and letter of credit applicants generally; 
 (C) subject to Section 2.03(b)(iii), the expiry date of such requested
Letter of Credit would occur more than twelve months after the date of issuance or last extension, unless the Required Lenders have approved such expiry date; 

(D) the expiry date of such requested Letter of Credit would occur after the Letter of Credit Expiration Date, unless all the Lenders have
approved such expiry date; 
 (E) such Letter of Credit is in an initial amount less than $100,000, in the case of a commercial Letter of
Credit, or $500,000, in the case of a standby Letter of Credit, or is to be denominated in a currency other than Dollars; provided that the $500,000 minimum amount relating to a standby Letter of Credit shall not be applicable if the
applicable Domestic Borrower pays to the L/C Issuer in respect of such Letter of Credit an additional issuance fee in an amount to be agreed between such Domestic Borrower and the L/C Issuer from time to time; or 

(F) a default of any Lender’s obligations to fund under Section 2.03(c) exists or any Lender is at such time a Defaulting
Lender hereunder, unless (i) the applicable Domestic Borrower shall have Cash Collateralized an amount equal to such Lender’s Pro Rata Share of the full amount of such Letter of Credit, provided that the Cash Collateral in respect of such
Lender’s Pro Rata Share shall be released to such Domestic Borrower promptly upon request after the effective date of the replacement of such Lender in accordance with Section 11.15, or (ii) the L/C Issuer has otherwise entered
into satisfactory arrangements with such Domestic Borrower or such Lender to eliminate the L/C Issuer’s risk with respect to such Lender. 

(iii) The L/C Issuer shall be under no obligation to amend any Letter of Credit if (A) the L/C Issuer would have no obligation at such
time to issue such Letter of Credit in its amended form under the terms hereof, or (B) the Beneficiary of such Letter of Credit does not accept the proposed amendment to such Letter of Credit. 

(iv) On and after the date hereof, the Existing Letters of Credit shall be deemed for all purposes, including for purposes of the fees and
charges to be collected pursuant to this Section 2.03 for periods on and after the date hereof, and reimbursement of costs and expenses to the extent provided herein, to be Letters of Credit outstanding under this Agreement and entitled
to the benefits of this Agreement and the other Loan Documents, and shall be governed by the applications and agreements pertaining thereto and by this Agreement; provided, however, that, notwithstanding any other provision of this Agreement,
no fees with respect to the initial issuance of the Existing Letters of Credit shall be due hereunder. 

  
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 (b) Procedures for Issuance and Amendment of Letters of Credit; Auto-Extension Letters of
Credit. 
 (i) Each Letter of Credit shall be issued or amended, as the case may be, upon the request of the applicable Domestic
Borrower delivered to the L/C Issuer (with a copy to the Administrative Agent) in the form of a Letter of Credit Application, appropriately completed and signed by a Responsible Officer of such Domestic Borrower. Such Letter of Credit Application
must be received by the L/C Issuer and the Administrative Agent not later than 11:00 a.m. at least three Business Days (or such later date and time as the Administrative Agent and the L/C Issuer may agree in a particular instance in their sole
discretion) prior to the proposed issuance date or date of amendment, as the case may be. In the case of a request for an initial issuance of a Letter of Credit, such Letter of Credit Application shall specify in form and detail satisfactory to the
L/C Issuer: (A) the proposed issuance date of the requested Letter of Credit (which shall be a Business Day); (B) the amount thereof; (C) the expiry date thereof; (D) the name and address of the Beneficiary thereof; (E) the
documents to be presented by such Beneficiary in case of any drawing thereunder; (F) the full text of any certificate to be presented by such Beneficiary in case of any drawing thereunder; (G) the purpose and nature of the requested Letter
of Credit; and (H) such other matters as the L/C Issuer may require. In the case of a request for an amendment of any outstanding Letter of Credit, such Letter of Credit Application shall specify in form and detail satisfactory to the L/C
Issuer (A) the Letter of Credit to be amended; (B) the proposed date of amendment thereof (which shall be a Business Day); (C) the nature of the proposed amendment; and (D) such other matters as the L/C Issuer may require.
Additionally, the applicable Domestic Borrower shall furnish to the L/C Issuer and the Administrative Agent such other documents and information pertaining to such requested Letter of Credit issuance or amendment, including any Issuer Documents, as
the L/C Issuer or the Administrative Agent may require. 
 (ii) Promptly after receipt of any Letter of Credit Application, the L/C Issuer
will confirm with the Administrative Agent (by telephone or in writing) that the Administrative Agent has received a copy of such Letter of Credit Application from the applicable Domestic Borrower and, if not, the L/C Issuer will provide the
Administrative Agent with a copy thereof. Unless the L/C Issuer has received written notice from any Lender, the Administrative Agent or any Loan Party, at least one Business Day prior to the requested date of issuance or amendment of the applicable
Letter of Credit, that one or more applicable conditions contained in Article IV shall not then be satisfied, then, subject to the terms and conditions hereof, the L/C Issuer shall, on the requested date, issue a Letter of Credit for the
account of the applicable Domestic Borrower (or the applicable Subsidiary) or enter into the applicable amendment, as the case may be, in each case in accordance with the L/C Issuer’s usual and customary business practices. Immediately upon the
issuance of each Letter of Credit, each Lender shall be deemed to, and hereby irrevocably and unconditionally agrees to, purchase from the L/C Issuer a risk participation in such Letter of Credit in an amount equal to the product of such
Lender’s Pro Rata Share times the amount of such Letter of Credit. 
 (iii) If the applicable Domestic Borrower so requests in
any applicable Letter of Credit Application, the L/C Issuer shall issue a Letter of Credit that has automatic extension provisions (each, an “Auto-Extension Letter of Credit”); provided that any such Auto-Extension Letter of
Credit must permit the L/C Issuer to prevent any such extension at least once in each 

  
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twelve-month period (commencing with the date of issuance of such Letter of Credit) by giving prior notice to the Beneficiary thereof not later than a day (the “Non-Extension Notice
Date”) in each such twelve-month period to be agreed upon at the time such Letter of Credit is issued; provided further that the L/C issuer shall not exercise its right to prevent any such renewal unless the L/C Issuer determines
that it would have no obligation at such time to issue such Letter of Credit in its renewed form under the terms of this Agreement. Unless otherwise directed by the L/C Issuer, the applicable Domestic Borrower shall not be required to make a
specific request to the L/C Issuer for any such extension. Once an Auto-Extension Letter of Credit has been issued, the Lenders shall be deemed to have authorized (but may not require) the L/C Issuer to permit the extension of such Letter of Credit
at any time to an expiry date not later than the Letter of Credit Expiration Date; provided, however, that the L/C Issuer shall not permit any such extension if (A) the L/C Issuer has determined that it would not be permitted, or would
have no obligation, at such time to issue such Letter of Credit in its revised form (as extended) under the terms hereof (by reason of the provisions of clause (ii) of Section 2.03(a) or otherwise), or (B) it has
received notice (which may be by telephone or in writing) on or before the day that is seven Business Days before the Non-Extension Notice Date (1) from the Administrative Agent that the Required Lenders have elected not to permit such
extension or (2) from the Administrative Agent, any Lender or the applicable Domestic Borrower that one or more of the applicable conditions specified in Section 4.02 is not then satisfied, and in each such case directing the L/C
Issuer not to permit such extension. 
 (iv) Promptly after its delivery of any Letter of Credit or any amendment to a Letter of Credit to
an advising bank with respect thereto or to the Beneficiary thereof, the L/C Issuer will also deliver to the applicable Domestic Borrower and the Administrative Agent a true and complete copy of such Letter of Credit or amendment. 

(c) Drawings and Reimbursements; Funding of Participations. 

(i) Upon receipt from the Beneficiary of any Letter of Credit of any notice of a drawing under such Letter of Credit, the L/C Issuer shall
notify the applicable Domestic Borrower and the Administrative Agent thereof. Not later than 11:00 a.m. on the date of any payment by the L/C Issuer under a Letter of Credit (each such date, an “Honor Date”), such Domestic Borrower
shall reimburse the L/C Issuer through the Administrative Agent in an amount equal to the amount of such drawing. If the applicable Domestic Borrower fails to so reimburse the L/C Issuer by such time, the Administrative Agent shall promptly notify
each Lender of the Honor Date, the amount of the unreimbursed drawing (the “Unreimbursed Amount”), and the amount of such Lender’s Pro Rata Share thereof. In such event, the applicable Domestic Borrower shall be deemed to have
requested a Borrowing of Base Rate Loans to be disbursed on the Honor Date in an amount equal to the Unreimbursed Amount, without regard to the minimum and multiples specified in Section 2.02 for the principal amount of Base Rate Loans,
but subject to the amount of the unutilized portion of the Aggregate Commitments and the conditions set forth in Section 4.02 (other than the delivery of a Committed Loan Notice). Any notice given by the L/C Issuer or the Administrative
Agent pursuant to this Section 2.03(c)(i) may be given by telephone if immediately confirmed in writing; provided that the lack of such an immediate confirmation shall not affect the conclusiveness or binding effect of such
notice. 

  
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 (ii) Each Lender shall upon any notice pursuant to Section 2.03(c)(i) make funds
available to the Administrative Agent for the account of the L/C Issuer at the Administrative Agent’s Office in an amount equal to its Pro Rata Share of the Unreimbursed Amount not later than 1:00 p.m. on the Business Day specified in such
notice by the Administrative Agent, whereupon, subject to the provisions of Section 2.03(c)(iii), each Lender that so makes funds available shall be deemed to have made a Base Rate Committed Loan to the applicable Domestic Borrower in
such amount. The Administrative Agent shall remit the funds so received to the L/C Issuer. 
 (iii) With respect to any Unreimbursed Amount
that is not fully refinanced by a Borrowing of Base Rate Loans because the conditions set forth in Section 4.02 cannot be satisfied or for any other reason, the applicable Domestic Borrower shall be deemed to have incurred from the L/C
Issuer an L/C Borrowing in the amount of the Unreimbursed Amount that is not so refinanced, which L/C Borrowing shall be due and payable on demand (together with interest) and shall bear interest at the Default Rate. In such event, each
Lender’s payment to the Administrative Agent for the account of the L/C Issuer pursuant to Section 2.03(c)(ii) shall be deemed payment in respect of its participation in such L/C Borrowing and shall constitute an L/C Advance from
such Lender in satisfaction of its participation obligation under this Section 2.03. 
 (iv) Until each Lender funds its
Committed Loan or L/C Advance pursuant to this Section 2.03(c) to reimburse the L/C Issuer for any amount drawn under any Letter of Credit, interest in respect of such Lender’s Pro Rata Share of such amount shall be solely for the
account of the L/C Issuer. 
 (v) Each Lender’s obligation to make Committed Loans or L/C Advances to reimburse the L/C Issuer for
amounts drawn under Letters of Credit, as contemplated by this Section 2.03(c), shall be absolute and unconditional and shall not be affected by any circumstance, including (A) any setoff, counterclaim, recoupment, defense or other
right which such Lender may have against the L/C Issuer, the applicable Domestic Borrower or any other Person for any reason whatsoever; (B) the occurrence or continuance of a Default, or (C) any other occurrence, event or condition,
whether or not similar to any of the foregoing; provided, however, that each Lender’s obligation to make Committed Loans pursuant to this Section 2.03(c) is subject to the conditions set forth in Section 4.02
(other than delivery by the applicable Domestic Borrower of a Committed Loan Notice). No such making of an L/C Advance shall relieve or otherwise impair the obligation of the applicable Domestic Borrower to reimburse the L/C Issuer for the amount of
any payment made by the L/C Issuer under any Letter of Credit, together with interest as provided herein. 
 (vi) If any Lender fails to
make available to the Administrative Agent for the account of the L/C Issuer any amount required to be paid by such Lender pursuant to the foregoing provisions of this Section 2.03(c) by the time specified in
Section 2.03(c)(ii), the L/C Issuer shall be entitled to recover from such Lender (acting through the Administrative Agent), on demand, such amount with interest thereon for the period from the date such payment is required to the date
on which such payment is immediately available to the L/C Issuer at a rate per annum equal to the greater of the Federal Funds Rate and a rate determined by the L/C Issuer in accordance with banking industry rules on interbank compensation. A
certificate of the L/C Issuer submitted to any Lender (through the Administrative Agent) with respect to any amounts owing under this clause (vi) shall be conclusive absent manifest error. 

  
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 (d) Repayment of Participations. 

(i) At any time after the L/C Issuer has made a payment under any Letter of Credit and has received from any Lender such Lender’s L/C
Advance in respect of such payment in accordance with Section 2.03(c), if the Administrative Agent receives for the account of the L/C Issuer any payment in respect of the related Unreimbursed Amount or interest thereon (whether directly
from the applicable Domestic Borrower or otherwise, including proceeds of Cash Collateral applied thereto by the Administrative Agent), the Administrative Agent will distribute to such Lender its Pro Rata Share thereof (appropriately adjusted, in
the case of interest payments, to reflect the period of time during which such Lender’s L/C Advance was outstanding) in the same funds as those received by the Administrative Agent. 

(ii) If any payment received by the Administrative Agent for the account of the L/C Issuer pursuant to Section 2.03(c)(i) is
required to be returned under any of the circumstances described in Section 11.05 (including pursuant to any settlement entered into by the L/C Issuer in its discretion), each Lender shall pay to the Administrative Agent for the account
of the L/C Issuer its Pro Rata Share thereof on demand of the Administrative Agent, plus interest thereon from the date of such demand to the date such amount is returned by such Lender, at a rate per annum equal to the Federal Funds Rate from time
to time in effect. The obligations of the Lenders under this clause shall survive the payment in full of the Obligations and the termination of this Agreement. 

(e) Obligations Absolute. The obligation of the applicable Domestic Borrower to reimburse the L/C Issuer for each drawing under each
Letter of Credit and to repay each L/C Borrowing shall be absolute, unconditional and irrevocable, and shall be paid strictly in accordance with the terms of this Agreement under all circumstances, including the following: 

(i) any lack of validity or enforceability of such Letter of Credit, this Agreement, or any other Loan Document; 

(ii) the existence of any claim, counterclaim, setoff, defense or other right that the applicable Domestic Borrower or any Subsidiary may have
at any time against any Beneficiary or any transferee of such Letter of Credit (or any Person for whom any such Beneficiary or any such transferee may be acting), the L/C Issuer or any other Person, whether in connection with this Agreement, the
transactions contemplated hereby or by such Letter of Credit or any agreement or instrument relating thereto, or any unrelated transaction; 

(iii) any draft, demand, certificate or other document presented under such Letter of Credit proving to be forged, fraudulent, invalid or
insufficient in any respect or any statement therein being untrue or inaccurate in any respect; or any loss or delay in the transmission or otherwise of any document required in order to make a drawing under such Letter of Credit; 

(iv) any payment by the L/C Issuer under such Letter of Credit against presentation of a draft or certificate that does not strictly comply
with the terms of such Letter of 

  
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Credit; or any payment made by the L/C Issuer under such Letter of Credit to any Person purporting to be a trustee in bankruptcy, debtor-in-possession, assignee for the benefit of creditors,
liquidator, receiver or other representative of or successor to any Beneficiary or any transferee of such Letter of Credit, including any arising in connection with any proceeding under any Debtor Relief Law; or 

(v) any other circumstance or happening whatsoever, whether or not similar to any of the foregoing, including any other circumstance that
might otherwise constitute a defense available to, or a discharge of, the applicable Domestic Borrower or any Subsidiary. 
 The applicable
Domestic Borrower shall promptly examine a copy of each Letter of Credit and each amendment thereto that is delivered to it and, in the event of any claim of noncompliance with the Company’s instructions or other irregularity, the Company will
immediately notify the L/C Issuer. Each Domestic Borrower shall be conclusively deemed to have waived any such claim against the L/C Issuer and its correspondents unless such notice is given as aforesaid. 

(f) Role of L/C Issuer. Each Lender and each Domestic Borrower agrees that, in paying any drawing under a Letter of Credit, the L/C
Issuer shall not have any responsibility to obtain any document (other than any sight draft, certificates and documents expressly required by the Letter of Credit) or to ascertain or inquire as to the validity or accuracy of any such document or the
authority of the Person executing or delivering any such document. None of the L/C Issuer, the Administrative Agent, any of their respective Related Parties nor any correspondent, participant or assignee of the L/C Issuer shall be liable to any
Lender for (i) any action taken or omitted in connection herewith at the request or with the approval of the Lenders or the Required Lenders, as applicable; (ii) any action taken or omitted in the absence of gross negligence or willful
misconduct; or (iii) the due execution, effectiveness, validity or enforceability of any document or instrument related to any Letter of Credit or Issuer Document. Each Domestic Borrower hereby assumes all risks of the acts or omissions of any
Beneficiary or transferee with respect to its use of any Letter of Credit; provided, however, that this assumption is not intended to, and shall not, preclude the applicable Domestic Borrower’s pursuing such rights and remedies as it may
have against the Beneficiary or transferee at law or under any other agreement. None of the L/C Issuer, the Administrative Agent, any of their respective Related Parties nor any correspondent, participant or assignee of the L/C Issuer shall be
liable or responsible for any of the matters described in clauses (i) through (v) of Section 2.03(e); provided, however, that anything in such clauses to the contrary notwithstanding, the applicable Domestic Borrower may
have a claim against the L/C Issuer, and the L/C Issuer may be liable to such Domestic Borrower, to the extent, but only to the extent, of any direct, as opposed to consequential or exemplary, damages suffered by such Domestic Borrower which such
Domestic Borrower proves were caused by the L/C Issuer’s willful misconduct or gross negligence or the L/C Issuer’s willful failure to pay under any Letter of Credit after the presentation to it by the Beneficiary of a sight draft and
certificate(s) strictly complying with the terms and conditions of a Letter of Credit. In furtherance and not in limitation of the foregoing, the L/C Issuer may accept documents that appear on their face to be in order, without responsibility for
further investigation, regardless of any notice or information to the contrary, and the L/C Issuer shall not be responsible for the validity or sufficiency of any instrument transferring or assigning or purporting to transfer or assign a Letter of
Credit or the rights or benefits thereunder or proceeds thereof, in whole or in part, which may prove to be invalid or ineffective for any reason. 

  
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 (g) Cash Collateral. Upon the request of the Administrative Agent, (i) if the L/C
Issuer has honored any full or partial drawing request under any Letter of Credit and such drawing has resulted in an L/C Borrowing, (ii) if, as of the Letter of Credit Expiration Date, any L/C Obligation for any reason remains outstanding or
(iii) if, prior to the maturity date thereof, prepayment of a Bankers’ Acceptance is required by the provisions of Section 2.04(g)(ii) or 2.04(k), the applicable Domestic Borrowers shall, in each case, immediately Cash
Collateralize the then Outstanding Amount of all L/C Obligations or McKesson Canada shall immediately Cash Collateralize the then Outstanding Amount of all Bankers’ Acceptances, as applicable. Sections 2.03(a)(ii)(E), 2.04,
2.05 and 8.02(c) set forth certain additional requirements to deliver Cash Collateral hereunder. For purposes of this Section 2.03, Section 2.04, Section 2.05 and Section 8.02(c),
“Cash Collateralize” means to pledge and deposit with or deliver to the Administrative Agent, for the benefit of the L/C Issuer and the Lenders, as collateral for the L/C Obligations, or to the Canadian Administrative Agent, for the
benefit of the applicable Canadian Lenders, as applicable, cash or deposit account balances pursuant to documentation in form and substance satisfactory to the Administrative Agent, the Canadian Administrative Agent and the L/C Issuer (which
documents are hereby consented to by the Lenders). Derivatives of such term have corresponding meanings. Each Domestic Borrower hereby grants to the Administrative Agent, and McKesson Canada hereby grants to the Canadian Administrative Agent, for
the benefit of the L/C Issuer and the Lenders, a security interest in all such cash, deposit accounts and all balances therein and all proceeds of the foregoing. Cash Collateral shall be maintained in blocked, non-interest bearing deposit accounts
at Bank of America. For purposes of this Section 2.03, “Cash Collateral” means the cash and deposit account balances pledged and deposited with or delivered to the Applicable Agent, pursuant to a requirement to Cash
Collateralize the L/C Obligations or Bankers’ Acceptances. 
 (h) Applicability of ISP and UCP. Unless otherwise expressly
agreed by the L/C Issuer and the applicable Domestic Borrower when a Letter of Credit is issued (including any such agreement applicable to an Existing Letter of Credit), (i) the rules of the ISP, with the exception of Rule 5.09 thereof, shall
apply to each standby Letter of Credit, and (ii) the rules of the Uniform Customs and Practice for Documentary Credits, as most recently published by the International Chamber of Commerce at the time of issuance shall apply to each commercial
Letter of Credit. 
 (i) Letter of Credit Fees. The applicable Domestic Borrower shall pay to the Administrative Agent for the
account of each Lender in accordance with its Pro Rata Share a letter of credit fee for each Letter of Credit equal to the Applicable Rate times the daily maximum amount available to be drawn under such Letter of Credit (whether or not such
maximum amount is then in effect under such Letter of Credit). Such letter of credit fees shall be computed on a quarterly basis in arrears. Such letter of credit fees shall be due and payable on the fifth Business Day following the end of each
calendar quarter, commencing with the first such date to occur after the issuance of such Letter of Credit, on the Letter of Credit Expiration Date and thereafter on demand. If there is any change in the Applicable Rate during any quarter, the daily
maximum amount of each Letter of Credit shall be computed and multiplied by the Applicable Rate separately for each period during such quarter that such Applicable Rate was in effect. 

  
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 (j) Fronting Fee and Documentary and Processing Charges Payable to L/C Issuer. The
applicable Domestic Borrower shall pay directly to the L/C Issuer for its own account a fronting fee with respect to each Letter of Credit in an amount equal to 0.125% per annum times the daily maximum amount available to be drawn under
such Letter of Credit. Such fronting fees shall be computed on a quarterly basis in arrears. Such fronting fees shall be due and payable on the first Business Day after the end of each calendar quarter, commencing with the first such date to occur
after the issuance of such Letter of Credit, on the Letter of Credit Expiration Date and thereafter on demand. For purposes of computing the daily amount available to be drawn under any Letter of Credit, the amount of such Letter of Credit shall be
determined in accordance with Section 1.07. In addition, the applicable Domestic Borrower shall pay directly to the L/C Issuer for its own account the customary issuance, presentation, amendment and other processing fees, and other
standard costs and charges (including reasonable out-of-pocket expenses relating to issuances, amendments, renewals, extensions and any demands for payment), of the L/C Issuer relating to letters of credit as from time to time in effect. Such
customary fees and standard costs and charges are due and payable on demand and are nonrefundable. 
 (k) Conflict with Issuer
Document. In the event of any conflict between the terms hereof and the terms of any Issuer Document, the terms hereof shall control. 

(l) Letters of Credit Issued for Subsidiaries. Notwithstanding that a Letter of Credit issued or outstanding hereunder is in support of
any obligations of, or is for the account of, a Subsidiary, the applicable Domestic Borrower shall be obligated to reimburse the L/C Issuer hereunder for any and all drawings under such Letter of Credit and to make any Cash Collateral deposits
required hereunder. The Company hereby acknowledges that the issuance of Letters of Credit for the account of Subsidiaries inures to the benefit of the Company, and that the Company’s business derives substantial benefits from the businesses of
such Subsidiaries. 
 (m) Reports to Administrative Agent. The L/C Issuer shall deliver to the Administrative Agent, upon each
calendar month end, a report setting forth for such period the daily aggregate amount available to be drawn under the Letters of Credit that were outstanding during such month. 

2.04 Bankers’ Acceptances for McKesson Canada. 

(a) Acceptance Commitment. 

(i) Each Canadian Lender severally agrees, on and subject to the terms and conditions set forth herein: (A) in the case of a Canadian
Lender that is able to accept Drafts from McKesson Canada, to create acceptances (each, a “Bankers’ Acceptance”) by accepting Drafts from McKesson Canada and to purchase such Bankers’ Acceptances in accordance with
Section 2.04(d); and (B) in the case of a Canadian Lender that has participated all or any part of its interest in the Bankers’ Acceptance Facilities to a participant that is able to accept Drafts from McKesson Canada, to
arrange for the creation of Bankers’ Acceptances by such participant and for the purchase of such Bankers’ Acceptances by such participant, to the extent of such participation or assignment, in accordance with Section 2.04(d).

  
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 (ii) Each Drawing shall be in an aggregate Face Amount of not less than Cdn.$5,000,000 and in
integral multiples of Cdn.$1,000,000 and shall consist of the creation and purchase of Bankers’ Acceptances on the same day, effected or arranged by the Canadian Lenders in accordance with Section 2.04(d), ratably according to their
respective Canadian Pro Rata Shares. 
 (iii) Anything contained in this Agreement to the contrary notwithstanding, the Bankers’
Acceptance Facility and the Canadian Commitments shall be subject to the following limitations: 
 (A) the amount otherwise available for
Drawing under the Aggregate Canadian Commitment as of any time of determination shall be reduced by an amount equal to the Total Canadian Outstandings as of such time of determination; 

(B) after any Drawing the Total Outstandings shall not exceed the Aggregate Commitments then in effect; 

(C) the issuance of any Bankers’ Acceptance shall not violate any policies of any Canadian Lender applicable to bankers’
acceptances and drawers generally; and 
 (D) after any Drawing the Total Canadian Outstandings shall not exceed the Aggregate Canadian
Commitments then in effect. 
 (b) Drawing Notice. 

(i) Each Drawing shall be made on three Business Days’ prior written notice specified in relation to Bankers’ Acceptances, given not
later than 11:00 a.m. (Eastern time), by McKesson Canada to the Canadian Administrative Agent. Each such notice of a Drawing (a “Drawing Notice”) shall be given in substantially the form of Exhibit E annexed hereto or by
telephone confirmed promptly in writing, containing the same information as would be contained in a Drawing Notice, and shall specify therein (A) the Drawing Date; (B) the aggregate Face Amount of Drafts to be accepted; and (C) the
maturity date for such Drafts. The Canadian Administrative Agent shall give each Canadian Lender prompt notice of such Drawing Notice and of such Canadian Lender’s ratable portion of Drafts to be accepted under the Drawing. 

(ii) McKesson Canada shall not request in a Drawing Notice a maturity date for Drafts that would be subsequent to the Maturity Date. 

(iii) Each Drawing Notice shall be irrevocable and binding on McKesson Canada. McKesson Canada shall indemnify each Canadian Lender against
any loss or expense incurred by such Canadian Lender as a result of any failure by McKesson Canada to fulfill or honor before the date specified for any Drawing, the applicable conditions set forth in this Section 2.04 or
Section 4.02, if the Drawing, as a result of such failure, is not made on such date. 
 (iv) McKesson Canada shall repay, and
there shall become due and payable, on the Drawing Date the principal amount of any Canadian Loans which McKesson Canada seeks to convert, if any, in whole or in part, to Bankers’ Acceptances on such Drawing Date. 

  
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 (v) None of the Canadian Administrative Agent, the Administrative Agent or the Canadian Lenders
shall incur any liability to any Borrower in acting on the telephonic notice referred to above which the Canadian Administrative Agent, the Administrative Agent or any Canadian Lenders believes in good faith to have been given by a duly authorized
officer or other person authorized to borrow on behalf of McKesson Canada or for otherwise acting in good faith under this Section 2.04 and upon the acceptance of Drafts pursuant to any such telephonic notice, McKesson Canada shall be
liable with respect thereto as provided herein. In the event of a conflict between the Canadian Administrative Agent’s record of the applicable terms of any Drawing and such Drawing Notice, the Canadian Administrative Agent’s record shall
prevail, absent manifest or demonstrable error. 
 (c) Form of Bankers’ Acceptances. 

(i) Each Draft presented by McKesson Canada shall (A) be dated the date of the Drawing; (B) mature and be payable by McKesson Canada
(in common with all other Drafts presented in connection with such Drawing) on a Business Day which occurs no less than 30 days nor more than 180 days after the date thereof, which term shall be specified on the Drawing Notice presented by McKesson
Canada in accordance with Section 2.04(b)(1); (C) be in a form reasonably acceptable to the Canadian Administrative Agent; and (D) if such Draft is drawn on a Canadian Lender that is a Member, be payable to the Clearing House.

 (ii) McKesson Canada hereby renounces, and shall not claim, any days of grace for the payment of any Bankers’ Acceptances. 

(d) Acceptance and Purchase of Drafts. 

(i) Not later than 11:00 a.m. (Eastern time) on an applicable Drawing Date, each Canadian Lender shall, as the case may be, (A) complete
one or more Drafts dated the date of such Drawing, with the maturity date specified by McKesson Canada in the Drawing Notice, accept such Drafts, and purchase the Bankers’ Acceptances thereby created for the Drawing Purchase Price; and
(B) arrange for its participant to complete one or more Drafts dated the date of such Drawing, with the maturity date specified by McKesson Canada in the Drawing Notice, to accept such Drafts and to purchase the Bankers’ Acceptances
thereby created for the Drawing Purchase Price. 
 (ii) The failure of any Canadian Lender to accept Drafts or purchase Bankers’
Acceptances as part of any Drawing shall not relieve such Canadian Lender of its obligation, if any, to accept Drafts and purchase Bankers’ Acceptances hereunder, but a Canadian Lender shall not be responsible for the failure of any other
Canadian Lender to accept Drafts or purchase Bankers’ Acceptance on the Drawing Date for any Drawing. 
 (iii) The parties hereto agree
that in the administering of Bankers’ Acceptances, each Canadian Lender may avail itself of the debt clearing services offered by the Clearing House and that the procedures set forth in Section 2.04 be deemed amended to the extent
necessary to comply with the requirements of such debt clearing services. The foregoing sentence applies only to the administration of Bankers’ Acceptances by the Canadian Lenders and shall not affect the rights and obligations of McKesson
Canada with respect to any Bankers’ Acceptance. 

  
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 (e) Payment of Drawing Purchase Price. 

(i) Subject to Section 2.04(b)(iv), each Canadian Lender shall, before 12:00 noon (Eastern time) on the applicable Drawing Date,
pay or cause to be paid, the Drawing Purchase Price in respect of any Bankers’ Acceptances which such Canadian Lender has purchased or arranged to have purchased pursuant to Section 2.04(d)(i) by depositing or causing to be
deposited such amount to such account maintained by the Canadian Administrative Agent at BA Canada as shall have been notified to such Canadian Lender by the Canadian Administrative Agent, in Canadian Dollars in same day funds. Promptly upon receipt
of such funds, the Canadian Administrative Agent shall make such funds available to McKesson Canada in accordance with reasonable instructions provided to the Canadian Administrative Agent by McKesson Canada. 

(ii) Bankers’ Acceptances purchased by a Canadian Lender or its participant hereunder may be held by such Canadian Lender or such
participant, as the case may be, for its own account until maturity or sold by it at any time prior thereto in any relevant market therefor in Canada, in such Lender’s or its participant’s sole discretion. 

(f) Effective Discount Rate Determination. Promptly upon request of McKesson Canada, the Canadian Administrative Agent shall provide
McKesson Canada an indicative Effective Discount Rate, which rate shall not be binding on the Canadian Administrative Agent, the Administrative Agent or the Lenders for purposes of any Drawing or acceptance of Drafts. 

(g) Payment at Maturity; Cash Collateral. 

(i) McKesson Canada shall pay to the Canadian Administrative Agent, and there shall become due and payable, at 12:00 noon (Eastern time) on
the maturity date for each Bankers’ Acceptance an amount in Canadian Dollars in same day funds equal to the Face Amount of such Bankers’ Acceptance. McKesson Canada shall make each payment hereunder in respect of Bankers’ Acceptances
by deposit of the required funds to the Canadian Administrative Agent at the Canada Administrative Agent’s Office. Upon receipt of such payment, the Canadian Administrative Agent will promptly thereafter cause such payment to be distributed in
like funds in payment of Bankers’ Acceptances ratably (based on the proportion that the aggregate Face Amount of Bankers’ Acceptances held by any Canadian Lender or any participant thereof maturing on the relevant date bears to the
aggregate Face Amount of Bankers’ Acceptances accepted or held by all Canadian Lenders or any participants or assignees thereof maturing on such date) to Canadian Lenders for their account and for the account of any participant, to the extent
of and in accordance with their participation. Such payment to the Canadian Administrative Agent shall satisfy McKesson Canada’s obligations under any Bankers’ Acceptances to which it relates and each Canadian Lender that has accepted such
Bankers’ Acceptances shall thereafter be solely responsible for the payment of such Bankers’ Acceptances and shall indemnify and hold McKesson Canada harmless against any liabilities, costs or expenses incurred by McKesson Canada as a
result of any failure by such Canadian Lender or such participant to pay such Bankers’ Acceptance in accordance with its terms. 

  
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 (ii) If McKesson Canada fails to pay any Bankers’ Acceptance when due, or to convert or
renew the Face Amount of such Bankers’ Acceptance pursuant to Section 2.04(i), the unpaid amount due and payable in respect thereof shall be converted as of such date, and without any necessity for McKesson Canada to give a
Committed Loan Notice in accordance with Section 2.02, to, and thereafter be outstanding as, a Canadian Prime Rate Loan made by, the Canadian Lenders and shall bear interest calculated and payable as provided in Section 2.08.
Each Borrower acknowledges, agrees and confirms with the Canadian Lenders that the records of each Canadian Lender in respect of payment of any Bankers’ Acceptance by such Canadian Lender shall be binding on McKesson Canada and shall be
conclusive evidence (in the absence of manifest error) of a Canadian Prime Rate Loan to an amount owing by McKesson Canada to such Canadian Lender. McKesson Canada further agrees that if an Event of Default or the Maturity Date shall occur prior to
the date upon which any one or more Bankers’ Acceptances are payable by a Canadian Lender, thereupon, McKesson Canada shall Cash Collateralize the full Face Amounts of all such Bankers’ Acceptances as provided in
Section 2.03(g), notwithstanding the fact that any such Bankers’ Acceptance may be held by such Canadian Lender in its own right at maturity; provided, however, that if for any reason McKesson Canada fails to so Cash
Collateralize any Bankers’ Acceptance, thereupon McKesson Canada shall be deemed for all purposes to have received a Canadian Prime Rate Loan in an amount equal to the Face Amount of such Bankers’ Acceptance and McKesson Canada shall pay
interest thereon at the Canadian Prime Rate until repayment thereof in full. 
 (h) Presigned Draft Forms. 

(i) To enable the Canadian Lenders to create Bankers’ Acceptances or complete Drafts in the manner specified in this
Section 2.04, McKesson Canada shall supply each Canadian Lender with such number of Drafts as such Canadian Lender may reasonably request, duly endorsed and executed on behalf of McKesson Canada by any one or more of its authorized
officers. Each Canadian Lender shall exercise such care in the custody and safekeeping of Drafts as it would exercise in the custody and safekeeping of similar property owned by it. Each Canadian Lender will, upon request by McKesson Canada,
promptly advise McKesson Canada of the number and designations, if any, of the uncompleted Drafts then held by it. The signatures of such officers may be mechanically reproduced in facsimile and Drafts and Bankers’ Acceptances bearing such
facsimile signatures shall be binding upon McKesson Canada as if they had been manually signed by such officers. Notwithstanding that any of the individuals whose manual or facsimile signature appears on any Draft or Bankers’ Acceptance as one
of such officers may no longer hold office at the date thereof or at the date of its acceptance by a Canadian Lender or a participant hereunder or at any time thereafter, any Draft or Bankers’ Acceptance so signed shall be valid and binding
upon McKesson Canada. 
 (ii) To facilitate the acceptance of Drafts hereunder, McKesson Canada hereby appoints each Canadian Lender as its
attorney to sign and endorse on its behalf, as and when considered necessary by such Canadian Lender in connection with a Drawing, an appropriate number of Drafts in the form prescribed by that Canadian Lender. Any Draft signed by a Canadian Lender
as attorney for McKesson Canada, whether signed in handwriting or by the facsimile or mechanical signature of an authorized officer of a Canadian Lender, may be dealt with by the Canadian Administrative Agent or any Canadian Lender to all intents
and purposes and shall bind McKesson Canada as if duly signed and issued by McKesson Canada. 

  
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 (i) Conversion or Renewal of Bankers’ Acceptances. Upon the maturity of a
Bankers’ Acceptance, McKesson Canada may elect to (A) renew such Bankers’ Acceptance, by giving a Drawing Notice in accordance with Section 2.04(b)(i); or (B) have all or a portion of the Face Amount of such
Bankers’ Acceptance converted to a Eurodollar Rate Loan or Canadian Prime Rate Loan, by giving a Committed Loan Notice in accordance with Section 2.02. If the Bankers’ Acceptances to be converted cannot be converted into a
Eurodollar Rate Loan or Canadian Prime Rate Loan in an aggregate amount which may be made as a Eurodollar Rate Loan or Canadian Prime Rate Loan, as the case may be, under this Agreement, then the amount which cannot be so converted shall be repaid
to the Canadian Administrative Agent for distribution to the Canadian Lenders in accordance with Section 2.04(g) on the date of such conversion. 

(j) Circumstances Making Bankers’ Acceptances Unavailable. 

(i) If the Canadian Administrative Agent determines in good faith, which determination shall be final, conclusive and binding upon McKesson
Canada, and notifies McKesson Canada that, by reason of circumstances affecting the money market (A) there is no market for Bankers’ Acceptances; or (B) the demand for Bankers’ Acceptances is insufficient to allow the sale or
trading of the Bankers’ Acceptances created and purchased hereunder; then, 
 (1) the right of McKesson Canada to request a Drawing
shall be suspended until the Canadian Administrative Agent determines that the circumstances causing such suspension no longer exist and the Canadian Administrative Agent so notifies McKesson Canada; and 

(2) any Drawing Notice which is outstanding shall be cancelled and the Drawing requested therein shall not be made. 

(ii) The Canadian Administrative Agent shall promptly notify McKesson Canada and the Administrative Agent of the suspension of McKesson
Canada’s right to request a Drawing and of the termination of any such suspension. 
 (k) Prepayments. Except as required by
Article VIII, Section 2.05 or Section 2.07, no repayment of a Bankers’ Acceptance shall be made by McKesson Canada to a Canadian Lender prior to the maturity date thereof. Any such repayment, made as required by
Article VIII, Section 2.05 or Section 2.07, shall be made (unless such repayment has been rescinded or otherwise is required to be returned by such Canadian Lender to McKesson Canada for any reason) in accordance with
the provisions of Section 2.03(g) and Section 2.04(g). Any such payment by McKesson Canada to the Canadian Administrative Agent shall satisfy McKesson Canada’s obligations under the Bankers’ Acceptance to which it
relates and, in the case of a Bankers’ Acceptance which has been accepted by a Canadian Lender or its participant, such Canadian Lender or such participant shall thereafter be solely responsible for the payment of such Bankers’ Acceptance
and shall indemnify and hold McKesson Canada harmless against any liabilities, costs or expenses incurred by McKesson Canada as a result of any failure by such Canadian Lender or such participant to pay such Bankers’ Acceptance in accordance
with its terms. 

  
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 2.05 Prepayments. 

(a) The Applicable Borrower may, upon notice to the Applicable Agent, at any time or from time to time voluntarily prepay Domestic Loans or
Canadian Loans, as the case may be, in whole or in part without premium or penalty; provided that (i) such notice must be received by the Applicable Agent not later than 9:00 a.m., in the case of a prepayment of Domestic Loans, and 11:00
a.m. (Eastern time) in the case of prepayment of Canadian Loans, (A) three Business Days prior to any date of prepayment of Eurodollar Rate Loans and (B) on the date of prepayment of Base Rate Committed Loans and Canadian Prime Rate Loans;
(ii) any prepayment of Domestic Loans shall be in a principal amount of $5,000,000 or a whole multiple of $1,000,000 in excess thereof; and (iii) any prepayment of Canadian Loans shall be in a principal amount of Cdn.$5,000,000 or a whole
multiple of Cdn.$1,000,000 in excess thereof or, in each case, if less, the entire principal amount thereof then outstanding. Each such notice shall specify the date and amount of such prepayment and the Type(s) of Committed Loans to be prepaid. The
Applicable Agent will promptly notify each Lender or Canadian Lender, as appropriate, of its receipt of each such notice, and of the amount of such Lender’s Pro Rata Share or Canadian Pro Rata Share, as appropriate, of such prepayment. If such
notice is given by a Borrower, the Applicable Borrower shall make such prepayment and the payment amount specified in such notice shall be due and payable on the date specified therein. Any prepayment of a Eurodollar Rate Loan shall be accompanied
by all accrued interest thereon, together with any additional amounts required pursuant to Section 3.05. Each such prepayment shall be applied to the Committed Loans of the Lenders in accordance with their respective Pro Rata Shares or
Canadian Pro Rata Shares, as appropriate. 
 (b) Subject to Section 2.14, if for any reason the Total Outstandings at any time
exceed the Aggregate Commitments then in effect, the applicable Domestic Borrower shall immediately prepay Loans and/or Cash Collateralize the L/C Obligations and/or McKesson Canada shall immediately prepay Canadian Loans and/or Cash Collateralize
Bankers’ Acceptances in an aggregate amount equal to such excess; provided, however, that the Borrowers shall not be required to Cash Collateralize the L/C Obligations or prepay the Face Amounts of Bankers’ Acceptances pursuant to
this Section 2.05(b) unless after the prepayment in full of the Committed Loans the Total Outstandings exceed the Aggregate Commitments then in effect. 

(c) Subject to Section 2.14, if for any reason the Total Canadian Outstandings at any time exceed the Aggregate Canadian
Commitments then in effect, McKesson Canada shall immediately prepay Canadian Loans and Cash Collateralize Bankers’ Acceptances in an aggregate amount equal to such excess, provided that McKesson Canada shall not be required to prepay
the Bankers’ Acceptances pursuant to this Section 2.05(c) unless, after prepayment in full of the Canadian Loans, the Total Canadian Outstandings exceed the Aggregate Canadian Commitments then in effect. 

2.06 Termination or Reduction of Commitments. The Company may, upon notice to the Applicable Agent, terminate the Aggregate Commitments or the
Aggregate Canadian Commitments, or from time to time permanently reduce the Aggregate Commitments or the Aggregate Canadian Commitments; provided that (i) any such notice shall be received by the Applicable Agent not later than 9:00 a.m.
or, in the case of a reduction of the Canadian Commitments, 11:00 a.m. (Eastern time) five Business Days prior to the date of termination or reduction, (ii) any such partial reduction shall be in an

  
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aggregate amount of $10,000,000 or any whole multiple of $1,000,000 in excess thereof, (iii) the Company shall not terminate or reduce the Aggregate Commitments if, after giving effect
thereto and to any concurrent prepayments hereunder, the Total Outstandings would exceed the Aggregate Commitments, (iv) the Company shall not terminate or reduce the Aggregate Canadian Commitments if, after giving effect thereto and to any
concurrent prepayments hereunder, the Total Canadian Outstandings would exceed the Aggregate Canadian Commitments, (v) if, after giving effect to any reduction of the Aggregate Commitments, the Letter of Credit Sublimit exceeds the amount of
the Aggregate Commitments, such Sublimit shall be automatically reduced by the amount of such excess, and (vi) if, after giving effect to any reduction of the Aggregate Commitments, the Aggregate Canadian Commitments exceed the amount of the
Aggregate Commitments, the Aggregate Canadian Commitments shall be automatically reduced by the amount of such excess. The Administrative Agent will promptly notify the Lenders of any such notice of termination or reduction of the Aggregate
Commitments and the Canadian Administrative Agent will promptly notify the Canadian Lenders of any such notice of termination or reduction of the Aggregate Canadian Commitments. Any reduction of the Aggregate Commitments or Aggregate Canadian
Commitments shall be applied to the Commitment of each Lender or the Canadian Commitment of each Canadian Lender, as the case may be, according to its Pro Rata Share or its Canadian Pro Rata Share, as the case may be. All facility fees accrued until
the effective date of any termination of the Aggregate Commitments shall be paid on the effective date of such termination. 
 2.07 Repayment of
Loans. The Applicable Borrower shall repay to the Lenders on the Maturity Date the aggregate principal amount of its Committed Loans outstanding on such date. McKesson Canada shall repay to the Lenders on the date that it ceases to be a
Wholly-Owned Subsidiary the aggregate principal amount of its Canadian Loans outstanding on such date. 
 2.08 Interest. 

(a) Subject to the provisions of Section 2.08(b), (i) each Eurodollar Rate Loan shall bear interest on the outstanding
principal amount thereof for each Interest Period at a rate per annum equal to the Eurodollar Rate for such Interest Period plus the Applicable Rate; (ii) each Base Rate Committed Loan shall bear interest on the outstanding principal amount
thereof from the applicable borrowing date at a rate per annum equal to the Base Rate plus the Applicable Rate; and (iii) each Canadian Prime Rate Loan shall bear interest on the outstanding principal amount thereof from the applicable
borrowing date at a rate per annum equal to the Canadian Prime Rate plus the Applicable Rate. 
 (b) If any amount payable by a Borrower
under any Loan Document is not paid when due (without regard to any applicable grace periods), whether at stated maturity, by acceleration or otherwise, such amount shall thereafter bear interest at a fluctuating interest rate per annum at all times
equal to the Default Rate to the fullest extent permitted by applicable Laws. Furthermore, upon the request of the Required Lenders, while any Event of Default exists, the Borrowers shall pay interest on the principal amount of all outstanding
Obligations hereunder at a fluctuating interest rate per annum at all times equal to the Default Rate to the fullest extent permitted by applicable Laws. Accrued and unpaid interest on past due amounts (including interest on past due interest) shall
be due and payable upon demand. 
 (c) Interest on each Loan shall be due and payable in arrears on each Interest Payment Date applicable
thereto and at such other times as may be specified herein. Interest hereunder shall be due and payable in accordance with the terms hereof before and after judgment, and before and after the commencement of any proceeding under any Debtor Relief
Law. 

  
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 2.09 Fees. In addition to certain fees described in Sections 2.03(i) and (j) and Section 2.04:

 (a) Facility Fee. The Company shall pay to the Administrative Agent for the account of each Lender in accordance with its Pro Rata
Share, a facility fee on the later of the fifth Business Day following the end of each calendar quarter or the fifth Business Day after the Company has received from the Administrative Agent a notice setting forth the amount of such fee, which shall
be equal to the Applicable Rate times the actual daily amount of the Aggregate Commitments (or, if the Aggregate Commitments have terminated, on the Outstanding Amount of all Committed Loans, Bankers’ Acceptances and L/C Obligations),
regardless of usage. The facility fee shall accrue at all times during the Availability Period (and thereafter so long as any Committed Loans, Bankers’ Acceptances or L/C Obligations remain outstanding), including at any time during which one
or more of the conditions in Article IV are not met, and shall be due and payable quarterly in arrears on each date specified above following the end of each calendar quarter, commencing with the first such date to occur after the date
hereof, and on the last day of the Availability Period (and, if applicable, thereafter on demand). The facility fee shall be calculated on a calendar quarter basis in arrears, and if there is any change in the Applicable Rate during any quarter, the
actual daily amount shall be computed and multiplied by the Applicable Rate separately for each period during such quarter that such Applicable Rate was in effect. 

(b) Other Fees. (i) The Company shall pay to the Arranger and the Administrative Agent for their own respective accounts fees in
the amounts and at the times specified in the Fee Letter. Such fees shall be fully earned when paid and, except to the extent expressly otherwise agreed, shall not be refundable for any reason whatsoever. 

(ii) The Borrowers shall pay to the Lenders such fees as shall have been separately agreed upon in writing in the amounts and at the times so
specified. Such fees shall be fully earned when paid and, except to the extent expressly otherwise agreed, shall not be refundable for any reason whatsoever. 

2.10 Computation of Interest and Fees. All computations of interest for Bankers’ Acceptances and Drawing Fees, for Canadian Prime Rate Loans and
for Base Rate Loans when the Base Rate is determined by Bank of America’s “prime rate” shall be made on the basis of a year of 365 or 366 days, as the case may be, and actual days elapsed. All other computations of fees and interest
shall be made on the basis of a 360-day year and actual days elapsed (which results in more fees or interest, as applicable, being paid than if computed on the basis of a 365-day year). Interest shall accrue on each Loan for the day on which the
Loan is made, and shall not accrue on a Loan, or any portion thereof, for the day on which the Loan or such portion is paid, provided that any Loan that is repaid on the same day on which it is made shall, subject to
Section 2.12(a), bear interest for one day. Each determination by the Administrative Agent and the Canadian Administrative Agent, as the case may be, of an interest rate or fee hereunder shall be conclusive and binding for all purposes,
absent manifest error. 
 2.11 Evidence of Debt. 

(a) The Credit Extensions made by each Lender shall be evidenced by one or more accounts or records maintained by such Lender and by the
Applicable Agent in the ordinary 

  
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course of business. The accounts or records maintained by the Administrative Agent, the Canadian Administrative Agent and each Lender shall be conclusive absent manifest error of the amount of
the Credit Extensions made by the Lenders to the Borrowers and the interest and payments thereon. Any failure to so record or any error in doing so shall not, however, limit or otherwise affect the obligation of the Borrowers hereunder to pay any
amount owing with respect to the Obligations. In the event of any conflict between the accounts and records maintained by any Lender and the accounts and records of either Agent in respect of such matters, the accounts and records of such Agent
shall control in the absence of manifest error. Upon the request of any Lender made through the Applicable Agent, the applicable Borrower shall execute and deliver to such Lender (through the Applicable Agent) a Note, which shall evidence such
Lender’s Loans in addition to such accounts or records. Each Lender may attach Schedules to its Note and endorse thereon the date, Type (if applicable), amount and maturity of its Loans and payments with respect thereto. 

(b) In addition to the accounts and records referred to in Section 2.11(a), each Lender and the Administrative Agent shall
maintain in accordance with its usual practice accounts or records evidencing the purchases and sales by such Lender of participations in Letters of Credit. In the event of any conflict between the accounts and records maintained by the
Administrative Agent and the accounts and records of any Lender in respect of such matters, the accounts and records of the Administrative Agent shall control in the absence of manifest error. 

2.12 Payments Generally. 
 (a) All
payments to be made by the Borrowers shall be made without condition or deduction for any counterclaim, defense, recoupment or setoff. Except as otherwise expressly provided herein, all payments by the Domestic Borrowers hereunder shall be made to
the Administrative Agent, for the account of the Lenders, at the Administrative Agent’s Office in Dollars not later than 12:00 noon on the date specified herein, and all payments by McKesson Canada hereunder shall be made to the Canadian
Administrative Agent for the account of the Canadian Lenders at the Canadian Administrative Agent’s Office in Canadian Dollars not later than 12:00 noon (Eastern time) on the date specified herein, in each case, in immediately available funds.
The Applicable Agent will promptly distribute to each Lender its Pro Rata Share and to each Canadian Lender its Canadian Pro Rata Share (or other applicable share as provided herein) of such payment in like funds as received by wire transfer to such
Lender’s Lending Office. All payments received by an Agent after the applicable time specified in this Section 2.12(a) shall be deemed received on the next succeeding Business Day and any applicable interest or fee shall continue to
accrue. If any payment to be made by a Borrower shall come due on a day other than a Business Day, payment shall be made on the next following Business Day, and such extension of time shall be reflected in computing interest or fees, as the case may
be. 
 (b)(i) Unless the Applicable Agent shall have received notice from a Lender prior to the proposed date of any Borrowing that such
Lender will not make available to such Agent such Lender’s share of such Borrowing, such Agent may assume that such Lender has made such share available on such date in accordance with Section 2.02 and may, in reliance upon such
assumption, make available to the Applicable Borrower a corresponding amount. In such event, if a Lender has not in fact made its share of the applicable Borrowing available to the Applicable 

  
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Agent, then such Lender and the Applicable Borrower severally agree to pay to the Applicable Agent forthwith on demand such corresponding amount in immediately available funds with interest
thereon, for each day from and including the date such amount is made available to the Applicable Borrower to but excluding the date of payment to such Agent, at (A) in the case of a payment to be made by such Lender, the greater of (1)(x), in
respect of Domestic Loans, the Federal Funds Rate and (y) in respect of Canadian Loans, the Overnight Canadian Rate from time to time in effect and (2) a rate determined by the Applicable Agent in accordance with banking industry rules on
interbank compensation, plus any administrative, processing or similar fees customarily charged by the Applicable Agent in connection with the foregoing, and (B) in the case of a payment to be made by the Applicable Borrower, the interest rate
applicable to the applicable Borrowing. If the Applicable Borrower and such Lender shall pay such interest to the Applicable Agent for the same or an overlapping period, the Applicable Agent shall promptly remit to the Applicable Borrower the amount
of such interest paid by the Applicable Borrower for such period. If such Lender pays its share of the applicable Borrowing to the Applicable Agent, then the amount so paid shall constitute such Lender’s Committed Loan included in such
Borrowing. Any payment by the Applicable Borrower shall be without prejudice to any claim the Applicable Borrower may have against a Lender that shall have failed to make such payment to the Applicable Agent. 

(ii) Unless the Applicable Agent shall have received notice from the Applicable Borrower prior to the date on which any payment is due to such
Agent for the account of the Lenders or the L/C Issuer hereunder that the Applicable Borrower will not make such payment, the Applicable Agent may assume that the Applicable Borrower has made such payment on such date in accordance herewith and may,
in reliance upon such assumption, distribute to the Lenders or the L/C Issuer, as the case may be, the amount due. In such event, if the Applicable Borrower has not in fact made such payment, then each of the Lenders or the L/C Issuer, as the case
may be, severally agrees to repay to the Applicable Agent forthwith on demand the amount so distributed to such Lender or the L/C Issuer, in immediately available funds with interest thereon, for each day from and including the date such amount is
distributed to it to but excluding the date of payment to such Agent, at the greater of (1)(x), in respect of Domestic Loans, the Federal Funds Rate and (y) in respect of Canadian Loans, the Overnight Canadian Rate from time to time in effect
and (2) a rate determined by the Applicable Agent in accordance with banking industry rules on interbank compensation. 
 A notice of
the Applicable Agent to any Lender or the Applicable Borrower with respect to any amount owing under this subsection (b) shall be conclusive, absent manifest error. 

(c) If any Lender makes available to either Agent funds for any Loan to be made by such Lender as provided in the foregoing provisions of this
Article II, and such funds are not made available to the Applicable Borrower by the Applicable Agent because the conditions to the applicable Credit Extension set forth in Article IV are not satisfied or waived in accordance with the
terms hereof, such Agent shall return such funds (in like funds as received from such Lender) to such Lender, without interest. 
 (d) The
obligations of the Lenders hereunder to make Committed Loans, to fund participations in Letters of Credit and to purchase Bankers’ Acceptances and to make payments pursuant to Section 11.04(c) are several and not joint. The failure
of any Lender to make any 

  
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Committed Loan, to fund any such participation, to make any such purchase or to make any payment under Section 11.04(c) on any date required hereunder shall not relieve any other
Lender of its corresponding obligation to do so on such date, and no Lender shall be responsible for the failure of any other Lender to so make its Committed Loan, fund its participation or purchase its Bankers’ Acceptance. 

(e) Nothing herein shall be deemed to obligate any Lender to obtain the funds for any Loan in any particular place or manner or to constitute
a representation by any Lender that it has obtained or will obtain the funds for any Loan in any particular place or manner. 
 2.13 Sharing of
Payments. If, other than as expressly provided elsewhere herein, any Lender shall obtain on account of the Committed Loans made by it, the Bankers’ Acceptance Facility or the participations in L/C Obligations held by it, any payment
(whether voluntary, involuntary, through the exercise of any right of set-off, or otherwise) in excess of its ratable share (or other share contemplated hereunder) thereof, such Lender shall immediately (a) notify the Administrative Agent of
such fact, and (b) purchase from the other Lenders such participations in the Committed Loans made by them or Bankers’ Acceptances and/or such subparticipations in the participations in L/C Obligations held by them, as the case may be, as
shall be necessary to cause such purchasing Lender to share the excess payment in respect of such Committed Loans, Bankers’ Acceptances or such participations, as the case may be, pro rata with each of them; provided, however, that if
all or any portion of such excess payment is thereafter recovered from the purchasing Lender under any of the circumstances described in Section 11.05 (including pursuant to any settlement entered into by the purchasing Lender in its
discretion), such purchase shall to that extent be rescinded and each other Lender shall repay to the purchasing Lender the purchase price paid therefor, together with an amount equal to such paying Lender’s ratable share (according to the
proportion of (i) the amount of such paying Lender’s required repayment to (ii) the total amount so recovered from the purchasing Lender) of any interest or other amount paid or payable by the purchasing Lender in respect of the total
amount so recovered, without further interest thereon; provided further that, for purposes of this Section 2.13, and subject to Section 2.01(b)(ii), no Lender other than a Canadian Lender that is a Canadian Resident
may purchase any portion of or any interest in a Canadian Loan or Bankers’ Acceptance. Each Borrower agrees that any Lender so purchasing a participation from another Lender may, to the fullest extent permitted by law, exercise all its rights
of payment (including the right of set-off, but subject to Section 11.08) with respect to such participation as fully as if such Lender were the direct creditor of such Borrower in the amount of such participation. The Administrative
Agent will keep records (which shall be conclusive and binding in the absence of manifest error) of participations purchased under this Section 2.13 and will in each case notify the Lenders following any such purchases or repayments.
Each Lender that purchases a participation pursuant to this Section 2.13 shall from and after such purchase have the right to give all notices, requests, demands, directions and other communications under this Agreement with respect to
the portion of the Obligations purchased to the same extent as though the purchasing Lender were the original owner of the Obligations purchased. 
 2.14
Currency Exchange Fluctuations. Subject to Section 3.02, if on any Computation Date the Administrative Agent or the Canadian Administrative Agent shall have determined that (a) the Total Outstandings exceed the Aggregate
Commitments by more than $5,000,000, or (b) the Total Canadian Outstandings exceed the Aggregate Canadian Commitments by more than $5,000,000, in either event due to a change in applicable rates of exchange between Dollars and Canadian Dollars,
then the Administrative Agent shall give notice to the Borrowers that a prepayment is required under this Section 2.14, and the Borrowers agree thereupon to make prepayments of Loans such that, after giving effect to such
prepayment, the Total Outstandings do not exceed the Aggregate Commitments and the Total Canadian Outstandings do not exceed the Aggregate Canadian Commitments. No prepayment of Loans is required pursuant to this Section 2.14 or
Section 2.05 in the event that the Total Outstandings exceed the Aggregate Commitments by $5,000,000 or less, or the Total Canadian Outstandings exceed the Aggregate Canadian Commitments by $5,000,000 or less, in either event solely due
to a change in applicable rates of exchange between Dollars and Canadian Dollars. 

  
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 2.15 Increase in Commitments. 

(a) Provided there exists no Default, upon notice to the Administrative Agent (which shall promptly notify the Lenders), the Company may from
time to time, request an increase in the Aggregate Commitments by an aggregate amount (for all such requests) not exceeding $700,000,000. At the time of sending such notice, the Company (in consultation with the Administrative Agent) shall specify
the time period within which each Lender is requested to respond (which shall in no event be less than ten Business Days from the date of delivery of such notice to the Lenders). Each Lender shall notify the Administrative Agent within such time
period whether or not it agrees to increase its Commitment and, if so, whether by an amount equal to, greater than, or less than its Pro Rata Share of such requested increase. Any Lender not responding within such time period shall be deemed to have
declined to increase its Commitment. The Administrative Agent shall notify the Company and each Lender of the Lenders’ responses to each request made hereunder. To achieve the full amount of a requested increase, the Company may also invite
additional Eligible Assignees to become Lenders pursuant to a joinder agreement in form and substance satisfactory to the Administrative Agent and its counsel. Notwithstanding the foregoing provisions of this Section 2.15(a), during the
first 90 days following the date hereof, the Company may invite Eligible Assignees to become Lenders under this Agreement in connection with a requested increase without first providing any Lender with the opportunity to increase its Commitment as
provided above. 
 (b) If the Aggregate Commitments are increased in accordance with this Section 2.15, the Administrative Agent
and the Company shall determine the effective date (the “Increase Effective Date”) and the final allocation of such increase. The Administrative Agent shall promptly notify the Company and the Lenders of the final allocation of such
increase and the Increase Effective Date. As a condition precedent to such increase, the Company shall deliver to the Administrative Agent a certificate of each Loan Party dated as of the Increase Effective Date signed by a Responsible Officer of
such Loan Party (i) certifying and attaching the resolutions adopted by such Loan Party approving or consenting to such increase, and (ii) in the case of the Company, certifying that, before and after giving effect to such increase,
(A) the representations and warranties contained in Article V and the other Loan Documents are true and correct on and as of the Increase Effective Date, except to the extent that such representations and warranties specifically refer to
an earlier date, in which case they are true and correct as of such earlier date, and except that, for purposes of this Section 2.15, (1) the representation and warranty contained in Section 5.08(a) shall be deemed to
refer to the most recent statements furnished pursuant to Sections 6.01(a) and (b), respectively, and (2) the reference to the date hereof in Section 5.05(b) and Section 5.08(b) shall be deemed to refer to
the Increase Effective Date and (B) no Default exists. The Company shall prepay any Committed Loans outstanding on the Increase Effective Date (and pay any additional amounts required pursuant to Section 3.05) to the extent
necessary to keep the outstanding Committed Loans ratable with any revised Pro Rata Shares arising from any nonratable increase in the Commitments under this Section 2.15. 

  
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 (c) In the event of an increase in Commitments pursuant to this Section 2.15, the
provisions of this Section 2.15 shall govern any conflicts with provisions in Sections 2.13 or 11.01. 
 2.16 Utilization of
Commitments in Canadian Dollars. 
 (a) The Administrative Agent will determine the Dollar Equivalent amount with respect to any
(i) Bankers’ Acceptance or Borrowing comprised of Canadian Loans that are Eurodollar Rate Loans as of the date which is three Business Days prior to the date of the requested Borrowing, (ii) Borrowing comprised of Canadian Prime Rate
Loans, one day prior to the requested date of Borrowing, (iii) outstanding Canadian Loans or Bankers’ Acceptances as of the last Business Day of each month, and (iv) conversions to or continuation of Canadian Loans as of the date the
related Committed Loan Notice is received by the Canadian Administrative Agent or, if such conversion or continuation is performed in accordance with Section 2.16(b) or Section 3.02, as of, in the case of
Section 2.16(b), the date that the request by the Required Lenders is received by the Administrative Agent or, in the case of Section 3.02, the date that the notice by the Administrative Agent is received by the Borrowers and
the Lenders (each such date under clauses (i) through (iv) a “Computation Date”). 
 (b) Notwithstanding anything
herein to the contrary, during the existence of a Default or an Event of Default, upon the request of the Required Lenders, all or any part of any outstanding Canadian Loans consisting of Eurodollar Rate Loans shall be converted into Canadian Prime
Rate Loans with effect from the last day of the Interest Period with respect to any such Canadian Loans. The Administrative Agent will promptly notify the Borrowers of any such conversion request. 

2.17 Extension of Maturity Date. 
 (a)
Requests for Extension. The Company may, by notice to the Administrative Agent, given not earlier than 90 days and not later than 65 days prior to each of the first and second anniversaries of the date hereof (each such anniversary being
referred to herein as an “Anniversary Date” and each such 25 day period prior to an Anniversary Date being referred to herein as a “Request Period”), request that each Lender, effective as of the first or second
Anniversary Date, as the case may be, extend its Commitment beyond the Maturity Date then in effect (the “Existing Maturity Date”) for an additional one-year period from the Existing Maturity Date; provided that no more than
one such request may be made during each Request Period. The Administrative Agent shall promptly notify each Lender of the Company’s request for such extension (the date such notice is given being referred to herein as the “Notice
Date”). 
 (b) Lender Elections to Extend. Each Lender, acting in its sole discretion, shall, by notice to the
Administrative Agent given not later than 10 days following the Notice Date (the “Response Deadline”), advise the Administrative Agent whether or not such Lender agrees to such extension (each such Lender that determines not to so
extend its Commitment being referred to as a “Non-Extending Lender”). Any Lender that does not so advise the Administrative Agent on or before the Response Deadline shall be deemed to be a Non-Extending Lender. The election of any
Lender to agree to such extension of the Maturity Date shall not obligate any other Lender to so agree. 

  
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 (c) Notification by Administrative Agent. The Administrative Agent shall notify the
Company of each Lender’s determination under this Section 2.17 within five Business Days after the Response Deadline. 

(d) Additional Commitment Lenders. The Company shall have the right on or before the related Anniversary Date to replace each
Non-Extending Lender with, and add as “Lenders” under this Agreement in place thereof, one or more Eligible Assignees (each, an “Additional Commitment Lender”) as provided in Section 11.06, provided that
each such Additional Commitment Lender shall enter into an Assignment and Assumption Agreement pursuant to which such Additional Commitment Lender shall undertake a Commitment (and, if any such Additional Commitment Lender is already a Lender, its
Commitment shall be in addition to such Lender’s Commitment hereunder on such date). 
 (e) Minimum Extension Requirement. If
(and only if) the total of the Commitments of the Lenders that have agreed to so extend the Maturity Date (each, an “Extending Lender”) and the Commitments of the Additional Commitment Lenders shall be more than 51% of the aggregate
amount of the Commitments in effect immediately prior to the related Anniversary Date, then, effective as of the related Anniversary Date (but subject to the prior satisfaction of the conditions set forth in clause (f) below), the Maturity Date
of this Agreement and the Maturity Date with respect to the Commitments of each Extending Lender and of each Additional Commitment Lender shall be extended to the date falling one year after the Existing Maturity Date (except that, if such date is
not a Business Day, such Maturity Date as so extended shall be the next preceding Business Day) and each Additional Commitment Lender shall thereupon become a “Lender” for all purposes of this Agreement. Notwithstanding anything herein to
the contrary, the Commitment of each Non-Extending Lender shall remain in full force and effect until and shall terminate on the Existing Maturity Date for such Non-Extending Lender, unless such Non-Extending Lender is replaced prior to the related
Anniversary Date by an Additional Commitment Lender as provided in clause (d) above. 
 (f) Conditions to Effectiveness of
Extensions. Notwithstanding the foregoing, the extension of the Maturity Date pursuant to this Section shall not be effective with respect to any Lender unless: 

(i) no Default shall exist, or would result from such extension; 

(ii) the representations and warranties of the Borrowers contained in this Agreement or any other Loan Document, or which are contained in any
document furnished at any time under or in connection herewith or therewith, shall be true and correct on and as of the date of such extension, except to the extent that such representations and warranties specifically refer to an earlier date, in
which case they shall be true and correct as of such earlier date; 
 (iii) as of the Anniversary Date, with respect to such extension no
Material Adverse Effect has occurred since March 31, 2011; and 
 (iv) the chief financial officer of the Company shall have delivered
to the Administrative Agent a certificate, dated the Anniversary Date with respect to such extension, as to the matters referred to in clauses (i) through (iii) above. 

  
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 (g) Payment of Non-Extending Lenders. On the Maturity Date of any Non-Extending Lender,
the Company shall repay any Committed Loans of such Non-Extending Lender outstanding on such date (and pay any additional amounts required pursuant to Sections 2.09 and 3.05). 

(h) Conflicting Provisions. This Section shall supersede any provisions in Section 11.01 to the contrary. 

2.18 Defaulting Lenders. 
 (a)
Adjustments. Notwithstanding anything to the contrary contained in this Agreement, if any Lender becomes a Defaulting Lender, then, until such time as that Lender is no longer a Defaulting Lender, to the extent permitted by applicable law:

 (i) Waivers and Amendments. Such Defaulting Lender’s right to approve or disapprove any amendment, waiver or consent with
respect to this Agreement shall be restricted as set forth in Section 11.01. 
 (ii) Reallocation of Payments. Any
payment of principal, interest, fees or other amounts received by Administrative Agent for the account of that Defaulting Lender (whether voluntary or mandatory, at maturity, pursuant to Article VIII or otherwise, and including any amounts
made available to any Agent by that Defaulting Lender pursuant to Section 11.08), will be applied at such time or times as may be determined by Agents as follows: FIRST, to the payment of any amounts owing by that Defaulting Lender to
any Agent hereunder; SECOND, to the payment on a pro rata basis of any amounts owing by that Defaulting Lender to the L/C Issuer hereunder; THIRD, if so determined by Administrative Agent or requested by the L/C Issuer, to be held as Cash Collateral
for future funding obligations of that Defaulting Lender of any participation in any Letter of Credit; FOURTH, as the Borrower may request (so long as no Default or Event of Default exists), to the funding of any Loan in respect of which that
Defaulting Lender has failed to fund its portion thereof as required by this Agreement, as determined by Administrative Agent; FIFTH, if so determined by Administrative Agent and the Borrowers and subject to Section 2.03(g), to be held
in a non-interest bearing deposit account and released in order to satisfy obligations of that Defaulting Lender to fund Loans under this Agreement; SIXTH, to the payment of any amounts owing to the Lenders or the L/C Issuer as a result of any
judgment of a court of competent jurisdiction obtained by any Lender or such L/C Issuer against that Defaulting Lender as a result of that Defaulting Lender’s breach of its obligations under this Agreement; SEVENTH, so long as no Default or
Event of Default exists, to the payment of any amounts owing to the Borrowers as a result of any judgment of a court of competent jurisdiction obtained by the Borrowers against that Defaulting Lender as a result of that Defaulting Lender’s
breach of its obligations under this Agreement; and EIGHTH, to that Defaulting Lender or as otherwise directed by a court of competent jurisdiction; provided that if (1) such payment is a payment of the principal amount of any Loans or
L/C Borrowings in respect of which that Defaulting Lender has not fully funded its appropriate share and (2) such Loans or L/C Borrowings were made at a time when the conditions set forth in Section 4.02 were satisfied or waived,
such payment will be applied solely to pay the Loans of, and L/C Borrowings owed to, all non-Defaulting Lenders on a pro rata basis prior to being applied to the payment of any Loans of, or L/C Borrowings owed to, that Defaulting Lender. Any
payments, 

  
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prepayments or other amounts paid or payable to a Defaulting Lender that are applied (or held) to pay amounts owed by a Defaulting Lender or to post Cash Collateral pursuant to this
Section 2.18(a)(ii) will be deemed paid to and redirected by that Defaulting Lender, and each Lender irrevocably consents hereto. 

(iii) Certain Fees. A Defaulting Lender (x) shall be entitled to receive any facility fee pursuant to Section 2.09(a) for any
period during which that Lender is a Defaulting Lender only to extent allocable to the sum of (1) the Outstanding Amount of the Committed Loans funded by it and (2) its Pro Rata Share of the stated amount of Letters of Credit for which it
has provided Cash Collateral pursuant to Section 2.03(g) or Section 2.18(a)(ii), as applicable (and the Borrower shall (A) be required to pay to each L/C Issuer, as applicable, the amount of such fee allocable to its Fronting Exposure
arising from that Defaulting Lender and (B) not be required to pay the remaining amount of such fee that otherwise would have been required to have been paid to that Defaulting Lender) and (y) shall be limited in its right to receive
Letter of Credit Fees as provided in Section 2.03(i). 
 (iv) Reallocation of Pro Rata Shares to Reduce Fronting Exposure.
During any period in which there is a Defaulting Lender, for purposes of computing the amount of the obligation of each non-Defaulting Lender to acquire, refinance or fund participations in Letters of Credit pursuant to Section 2.03, the
“Pro Rata Share” of each non-Defaulting Lender that is a Lender will be computed without giving effect to the Commitment of that Defaulting Lender; provided that, (A) each such reallocation will be given effect only if, at the
date the applicable Lender becomes a Defaulting Lender, no Default or Event of Default exists and (B) the aggregate obligation of each non-Defaulting Lender to acquire, refinance or fund participations in Letters of Credit shall not exceed the
positive difference, if any, of (1) the Commitment of that non-Defaulting Lender minus (2) the sum of (x) the aggregate Outstanding Amount of the Committed Loans of that non-Defaulting Lender, (y) that non-Defaulting
Lender’s Pro Rata Share of the then Outstanding Amount of any L/C Obligations and (z) that non-Defaulting Lender’s Pro Rata Share of the Outstanding Amount of the Acceptance Usage. 

(b) Defaulting Lender Cure. If the Borrower, Administrative Agent and L/C Issuer agree in writing in their sole discretion that a
Defaulting Lender should no longer be deemed to be a Defaulting Lender, Administrative Agent will so notify the parties hereto, whereupon as of the effective date specified in such notice and subject to any conditions set forth therein (which may
include arrangements with respect to any Cash Collateral), that Lender will, to the extent applicable, purchase that portion of outstanding Loans of the other Lenders or take such other actions as Administrative Agent may determine to be necessary
to cause the Loans and funded and unfunded participations in Letters of Credit to be held on a pro rata basis by the Lenders in accordance with their Pro Rata Shares (without giving effect to Section 2.18(a)(iv), whereupon that Lender
will cease to be a Defaulting Lender; provided that no adjustments will be made retroactively with respect to fees accrued or payments made by or on behalf of the Borrowers while that Lender was a Defaulting Lender; and provided,
further, that except to the extent otherwise expressly agreed by the affected parties, no change hereunder from Defaulting Lender to Lender will constitute a waiver or release of any claim of any party hereunder arising from that Lender’s
having been a Defaulting Lender. 

  
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 ARTICLE III 

TAXES, YIELD PROTECTION AND ILLEGALITY 

3.01 Taxes. 
 (a) Any and all payments by
the Borrowers to or for the account of any Agent or any Lender under any Loan Document shall be made free and clear of and without deduction for any and all present or future taxes, duties, levies, imposts, deductions, assessments, fees,
withholdings or similar charges, and all liabilities with respect thereto other than Excluded Taxes (such taxes, duties, levies, imposts, deductions, assessments, fees, withholdings or similar charges, and liabilities being hereinafter referred to
as “Taxes”). For purposes of any Loan Document, “Excluded Taxes” shall mean, in the case of each Agent and each Lender, (i) taxes imposed on or measured by its net income (however denominated), franchise taxes
(in lieu of net income taxes) and branch profits taxes, in each case, imposed on it by the jurisdiction (or any political subdivision thereof) under the Laws of which such Agent or such Lender, as the case may be, is organized or maintains a lending
office or carries on business through a permanent establishment, (ii) in the case of a Foreign Lender (other than an assignee pursuant to a request by the Borrower under Section 11.15), any United States withholding tax imposed on
amounts payable to such Foreign Lender with respect to an applicable interest in a Loan or Commitment pursuant to a law in effect at the time such Foreign Lender acquires such interest in the Loan or Commitment or designates a new lending office,
except in each case to the extent that amounts with respect to such taxes were payable either to such Foreign Lender’s assignor immediately before such Foreign Lender became a party hereto or to such Foreign Lender immediately before it changed
its lending office, and (iii) taxes imposed under FATCA. If the Borrowers or an Agent shall be required by any Laws to deduct any Taxes or Excluded Taxes from or in respect of any sum payable under any Loan Document to any Agent or any Lender,
(i) in the case of Taxes, the sum payable by the Applicable Borrower shall be increased as necessary so that after making all required deductions (including deductions applicable to additional sums payable under this Section 3.01),
each of such Agent and such Lender receives an amount equal to the sum it would have received had no such deductions been made, (ii) the Applicable Borrower or the Applicable Agent, as the case may be, shall make such deductions, (iii) the
Applicable Borrower or the Applicable Agent, as the case may be, shall pay the full amount deducted to the relevant taxation authority or other authority in accordance with applicable Laws, and (iv) within 30 days after the date of such
payment, where the payment is by the Applicable Borrower, the Applicable Borrower shall furnish to the Applicable Agent (which shall forward the same to such Lender) the original or a certified copy of a receipt evidencing payment thereof reasonably
satisfactory to the Applicable Agent. 
 (b) In addition, each Borrower agrees to pay, or at the option of the Applicable Agent timely
reimburse it for the payment of, any and all present or future stamp, court or documentary taxes and any other excise or property taxes or charges or similar levies which arise from any payment made under any Loan Document or from the execution,
delivery, performance, enforcement or registration of, from the receipt or perfection of a security interest under, or otherwise with respect to, any Loan Document (hereinafter referred to as “Other Taxes”). 

(c) Subject to Section 11.14(a)(iii), each Borrower agrees to indemnify each Agent and each Lender for (i) the full amount of
Taxes and Other Taxes (including any Taxes or Other 

  
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Taxes imposed or asserted by any jurisdiction on amounts payable under this Section 3.01) paid by such Agent and such Lender, and (ii) any liability (including additions to tax,
penalties, interest and expenses) arising therefrom or with respect thereto, in each case whether or not such Taxes or Other Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. Payment under this
Section 3.01(d) shall be made within 30 days after the date the Lender or the Applicable Agent makes a demand therefor. 
 (d)
If any Lender or Agent, as applicable, determines, in its sole discretion exercised in good faith, that it has received a refund (whether by way of a direct payment or by offset) of any Taxes or Other Taxes paid or indemnified by a Borrower under
this Section 3.01, it shall pay to the Applicable Borrower the amount of such refund (but only to the extent of payments by a Borrower made under this Section 3.01 with respect to the Taxes giving rise to such refund, and net
of all reasonable out-of-pocket expenses of such Lender or Agent and, for the avoidance of doubt, without interest other than any interest paid by the relevant Government Authority with respect to such refund) if (i) payment of the Taxes or
Other Taxes being refunded has been made in full as and when required pursuant to this Section 3.01 and (ii) such Borrower agrees in writing to repay the amount of such refund, together with any interest thereon, to the applicable
Lender or Agent in the event such Lender or Agent is required to repay such refund to the Governmental Authority that imposed the Tax or Other Tax being refunded. Notwithstanding anything to the contrary in this paragraph (e), in no event will the
Lender or Agent, as the case may be, be required to pay any amount to the Applicable Borrower, pursuant to this paragraph (e) the payment of which would place the Lender or Agent in a less favorable net after-tax position than it would have
been in if the indemnification payments or additional amounts giving rise to such refund had never been paid. This paragraph shall not be construed to require any Lender or Agent to make available its tax returns (or any other information relating
to its taxes that it deems confidential) to the Borrowers or any other Person. 
 3.02 Illegality. 

(a) If any Lender determines that any Law has made it unlawful, or that any Governmental Authority has asserted that it is unlawful, for any
Lender or its applicable Lending Office to make, maintain or fund Eurodollar Rate Loans (whether payable in Dollars or Canadian Dollars), or to determine or charge interest rates based upon the Eurodollar Rate, then, on notice thereof by such Lender
to the Borrowers through the Applicable Agent, any obligation of such Lender to make or continue Eurodollar Rate Loans or to convert Base Rate Committed Loans or Canadian Prime Rate Loans, as the case may be, to Eurodollar Rate Loans shall be
suspended until such Lender notifies the Applicable Agent and the Applicable Borrower that the circumstances giving rise to such determination no longer exist. Upon receipt of such notice, the Applicable Borrower shall, upon demand from such Lender
(with a copy to the Applicable Agent), prepay or, if applicable, convert all Eurodollar Rate Loans of such Lender to Base Rate Loans or Canadian Prime Rate Loans, as the case may be, either on the last day of the Interest Period therefor, if such
Lender may lawfully continue to maintain such Eurodollar Rate Loans to such day, or immediately, if such Lender may not lawfully continue to maintain such Eurodollar Rate Loans. Upon any such prepayment or conversion, the Applicable Borrower shall
also pay accrued interest on the amount so prepaid or converted. Each Lender agrees to designate a different Lending Office if such designation will avoid the need for such notice and will not, in the good faith judgment of such Lender, otherwise be
materially disadvantageous to such Lender. 

  
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 (b) Upon any Lender’s giving notice and suspending its obligations relating to Eurodollar
Rate Loans in accordance with Section 3.02(a), the Company may replace such Lender in accordance with Section 11.15. 
 3.03
Inability to Determine Rates. If the Required Lenders determine that for any reason adequate and reasonable means do not exist for determining the Eurodollar Base Rate for any requested Interest Period with respect to a proposed Eurodollar Rate
Loan, or that the Eurodollar Base Rate for any requested Interest Period with respect to a proposed Eurodollar Rate Loan does not adequately and fairly reflect the cost to such Lenders of funding such Loan, the Administrative Agent will promptly so
notify the Borrowers and each Lender. Thereafter, the obligation of the Lenders (including Canadian Lenders) to make or maintain Eurodollar Rate Loans shall be suspended until the Administrative Agent (upon the instruction of the Required Lenders)
revokes such notice. Upon receipt of such notice, the Borrowers may revoke any pending request for a Borrowing of, conversion to or continuation of Eurodollar Rate Loans or, failing that, will be deemed to have converted such request into a request
for a Borrowing of Base Rate Loans or Canadian Prime Rate Loans, as the case may be, in the amount specified therein. 
 3.04 Increased Cost and Reduced
Return; Capital Adequacy. 
 (a) Increased Costs Generally. If any Change in Law shall: 

(i) impose, modify or deem applicable any reserve, special deposit, compulsory loan, insurance charge or similar requirement against assets
of, deposits with or for the account of, or credit extended or participated in by, any Lender (except any reserve requirement reflected in the Eurodollar Rate) or the L/C Issuer; 

(ii) subject any Lender or Agent to any taxes of any kind whatsoever (other than (A) Taxes imposed on payments under any Loan Document,
(B) Other Taxes and (C) Excluded Taxes) on its loans, loan principal, letters of credit, commitments, or other obligations, or its deposits, reserves, other liabilities or capital attributable thereto; or 

(iii) impose on any Lender or the L/C Issuer or the London interbank market any other condition, cost or expense affecting this Agreement or
Eurodollar Loans made by such Lender or any Letter of Credit or participation therein; 
 and the result of any of the foregoing shall be to
increase the cost to such Lender of making, converting to, continuing or maintaining any Eurodollar Loan or of maintaining its obligation to make any such Loan, or to increase the cost to such Lender or L/C Issuer of participating in, issuing or
maintaining any Letter of Credit (or of maintaining its obligation to participate in or to issue any Letter of Credit), or to reduce the amount of any sum received or receivable by such Lender or L/C Issuer hereunder (whether of principal, interest
or any other amount) then, upon request of such Lender or L/C Issuer, the Borrower will pay to such Lender or L/C Issuer, as the case may be, such additional amount or amounts as will compensate such Lender or L/C Issuer, as the case may be, for
such additional costs incurred or reduction suffered. 

  
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 (b) Capital Requirements. If any Lender or L/C Issuer determines that any Change in Law
affecting such Lender or L/C Issuer or any lending office of such Lender or such Lender’s or L/C Issuer’s holding company, if any, regarding capital requirements, has or would have the effect of reducing the rate of return on such
Lender’s or L/C Issuer’s capital or on the capital of such Lender’s or L/C Issuer’s holding company, if any, as a consequence of this Agreement, the Commitments of such Lender or the Loans made by, or participations in Letters of
Credit held by, such Lender, or the Letters of Credit issued by the L/C Issuer, to a level below that which such Lender or L/C Issuer or such Lender’s or L/C Issuer’s holding company could have achieved but for such Change in Law (taking
into consideration such Lender’s or L/C Issuer’s policies and the policies of such Lender’s or L/C Issuer’s holding company with respect to capital adequacy), then from time to time the Borrower will pay to such Lender or L/C
Issuer, as the case may be, such additional amount or amounts as will compensate such Lender or L/C Issuer or such Lender’s or L/C Issuer’s holding company for any such reduction suffered. 

(c) Failure or delay on the part of any Lender to demand compensation pursuant to this Section 3.04 shall not constitute a waiver
of such Lender’s right to demand such compensation; provided that, notwithstanding the provisions of Sections 3.04(a) and (b), (i) the Borrowers shall only be liable for amounts in respect of increased costs or
reductions for the period beginning up to six months prior to the date on which such demand was made (except that, if the Change in Law giving rise to such increased costs or reductions is retroactive, then the six month period referred to above
shall be extended to include the period of retroactive effect thereof), and (ii) the Lender claiming compensation therefor shall have applied consistent return metrics applied to other similarly situated borrowers or obligors with respect to
such increased costs or reductions. 
 3.05 Funding Losses. Upon demand of any Lender (with a copy to the Administrative Agent) from time to time,
the Company shall promptly compensate such Lender for and hold such Lender harmless from any loss, cost or expense incurred by it as a result of: 

(a) any continuation, conversion, payment or prepayment of any Eurodollar Rate Loan on a day other than the last day of the Interest Period
for such Loan (whether voluntary, mandatory, automatic, by reason of acceleration, or otherwise); 
 (b) any failure by a Borrower (for a
reason other than the failure of such Lender to make a Loan) to prepay, borrow, continue or convert any Eurodollar Rate Loan on the date or in the amount notified by such Borrower; or 

(c) any assignment of a Eurodollar Rate Loan on a day other than the last day of the Interest Period therefor as a result of a request by the
Company pursuant to Section 11.15; including any loss of anticipated profits and any loss or expense arising from the liquidation or reemployment of funds obtained by it to maintain such Loan or from fees payable to terminate the
deposits from which such funds were obtained; 
 provided that the Company shall have no obligation to pay to any Lender any of the
foregoing amounts incurred in connection with such Lender being a Defaulting Lender. 
 For purposes of calculating amounts payable by the
Company to the Lenders under this Section 3.05, each Lender shall be deemed to have funded each Eurodollar Rate Loan made by it at the Eurodollar 

  
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Base Rate used in determining the Eurodollar Rate for such Loan by a matching deposit or other borrowing in the London interbank eurodollar market for a comparable amount and for a comparable
period, whether or not such Eurodollar Rate Loan was in fact so funded. 
 3.06 Matters Applicable to all Requests for Compensation. 

(a) A certificate of the Administrative Agent, the Canadian Administrative Agent or any Lender claiming compensation under this Article
III and setting forth the additional amount or amounts to be paid to it hereunder shall be conclusive in the absence of manifest error; provided that, in the case of any such certificate delivered pursuant to Section 3.04,
such certificate (i) sets forth in reasonable detail the amount or amounts payable to such Lender pursuant to Sections 3.04(a) and (b) and the basis for determining such amount or amounts and (ii) explains the methodology used
to determine such amount. The Applicable Borrower shall pay such Lender the amount shown as due on any such certificate within 10 days after receipt thereof. In determining such amount, the Administrative Agent, the Canadian Administrative Agent or
such Lender may use any reasonable averaging and attribution methods. 
 (b) Upon any Lender’s making a claim for compensation under
Section 3.04 or if any Borrower is required to pay amounts to any Lender under Section 3.01 as a result of any Taxes or Other Taxes, in each case the Company may replace such Lender in accordance with
Section 11.15. 
 3.07 Survival. All of the Borrowers’ obligations under this Article III shall survive termination of the
Aggregate Commitments and repayment of all other Obligations hereunder. 
 ARTICLE IV 

CONDITIONS PRECEDENT TO CREDIT EXTENSIONS 

4.01 Conditions to Effectiveness. Effectiveness of this Agreement is subject to satisfaction of the following conditions precedent: 

(a) The Administrative Agent’s receipt of the following, each of which shall be originals or facsimiles (followed promptly by originals)
unless otherwise specified, each properly executed by a Responsible Officer of the signing Loan Party, each dated the date hereof (or, in the case of certificates of governmental officials, a recent date before the date hereof) and each in form and
substance satisfactory to the Administrative Agent and each of the Lenders: 
 (i) executed counterparts of this Agreement, sufficient in
number for distribution to the Administrative Agent, the Canadian Administrative Agent, each Lender and each Loan Party; 
 (ii) if
requested by any Lender at least two Business Days before the date hereof, a Note executed by the Applicable Borrower in favor of each Lender so requesting a Note; 

(iii) such certificates of resolutions or other action, incumbency certificates and/or other certificates of Responsible Officers or the
corporate secretary or assistant secretary of the Company and McKesson Canada as the Administrative Agent may require evidencing the identity, authority and capacity of each Responsible Officer thereof authorized to act as a Responsible Officer in
connection with this Agreement and the other Loan Documents to which such Loan Party is a party; 

  
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 (iv) each of the following documents: 

(A) the Articles or certificate of incorporation and the bylaws of each Borrower as in effect on the date hereof, certified by the Secretary
or Assistant Secretary of such Borrower as of the date hereof; 
 (B) a good standing and tax good standing certificate for the Company
from the applicable Secretary of State (or similar, applicable Governmental Authority) of the States of Delaware and California dated as of a recent date; and 

(C) a certificate of status for McKesson Canada from the Registrar of Joint Stock Companies of Nova Scotia, dated as of a recent date; 

(v) favorable opinions, addressed to the Agents and the Lenders, of (A) Wade Estey, Senior Counsel of the Company, in form and substance
satisfactory to the Administrative Agent regarding such matters as the Administrative Agent may reasonably request; (B) Stewart, McKelvey, special Canadian counsel to the Company and McKesson Canada, as to certain matters of Canadian law; and
(C) Morrison & Foerster LLP, special counsel to the Company and McKesson Canada, as to certain matters of New York law; 

(vi) a certificate signed by a Responsible Officer of the Company: 

(A) certifying that: 
 (1) the
representations and warranties contained in Article V and the other Loan Documents are true and correct on and as of such date, as though made on and as of such date; 

(2) no Default or Event of Default exists or would result from the initial Borrowing; 

(3) there has occurred since March 31, 2011, no event or circumstance that has resulted or could reasonably be expected to result in a
Material Adverse Effect; 
 (4) each of the conditions in Sections 4.01(a) and (b) has been satisfied on the part of the Company
as of the date hereof; 
 (B) designating the date hereof; and 

(C) indicating the Debt Ratings; 

  
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 (vii) a certificate signed by a Responsible Officer of McKesson Canada certifying that: 

(A) the representations and warranties of McKesson Canada contained in Article V are true and correct on and as of the date hereof, as
though made on and as of such date; 
 (B) no Default or Event of Default with respect to McKesson Canada or any of its Subsidiaries exists
or would result from the initial Borrowing; 
 (C) there has occurred since March 31, 2011 no event or circumstance with respect to
McKesson Canada or any of its Subsidiaries that has resulted or could reasonably be expected to result in a Material Adverse Effect; and 

(D) each of the conditions in Sections 4.01(a) and (b) has been satisfied on the part of McKesson Canada as of the date hereof;

 (viii) such other assurances, certificates, documents, consents or opinions as the Administrative Agent, the Canadian Administrative
Agent, the L/C Issuer or the Required Lenders reasonably may require. 
 (b) Any fees required by the Loan Documents to be paid, and all
reimburseable expenses for which invoices have been presented, to either Agent, the L/C Issuer, the Arranger or any Lender on or before the date hereof shall have been paid, to the extent that such invoices have been presented to the Company on or
before the date hereof. 
 (c) Unless waived by the Administrative Agent, the Company shall have paid all Attorney Costs of the
Administrative Agent to the extent invoiced to the Company prior to or on the date hereof, plus such additional amounts of Attorney Costs as shall constitute its reasonable estimate of Attorney Costs incurred or to be incurred by it through the
proceedings (provided that such estimate shall not thereafter preclude a final settling of accounts between the Company and the Administrative Agent). 

(d) Since March 31, 2011, no Material Adverse Effect shall have occurred or become known to the Administrative Agent. 

(e) The commitments of the lenders under the Existing Revolving Credit Agreement shall have been terminated and all the obligations under the
Existing Revolving Credit Agreement shall have been repaid or prepaid (which repayment or prepayment may be made with the proceeds of the initial Credit Extension hereunder). 

Without limiting the generality of the provisions of Section 9.05, for purposes of determining compliance with the conditions
specified in this Section 4.01, each Lender that has signed this Agreement shall be deemed to have consented to, approved or accepted or to be satisfied with, each document or other matter required thereunder to be consented to or
approved by or acceptable or satisfactory to a Lender unless the Administrative Agent shall have received notice from such Lender prior to the proposed date hereof specifying its objection thereto. 

4.02 Existing Revolving Credit Agreement (a) On the date hereof, the “Commitments” as defined in the Existing Revolving Credit Agreement
shall terminate, without further action by any party thereto. 

  
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 (b) The Lenders which are parties to the Existing Revolving Credit Agreement, comprising the
“Required Lenders” as defined in the Existing Revolving Credit Agreement hereby waive any requirement of prior notice of termination of the Commitments (as defined in the Existing Revolving Credit Agreement) pursuant to Section 2.06
thereof and of prepayment of loans thereunder, to the extent necessary to give effect to 4.01(e) hereof, provided that any such prepayment of loans thereunder shall be subject to Section 2.05 of the Existing Revolving Credit Agreement.

 4.03 Conditions to all Credit Extensions. The obligation of each Lender to honor any Request for Credit Extension (other than a Committed Loan
Notice requesting only a conversion of Committed Loans to the other Type, or a continuation of Eurodollar Rate Loans) is subject to the following conditions precedent: 

(a) The representations and warranties of each Borrower contained in Article V or any other Loan Document, or which are contained in
any document furnished at any time under or in connection herewith or therewith, shall be true and correct on and as of the date of such Credit Extension, except to the extent that such representations and warranties specifically refer to an earlier
date, in which case they shall be true and correct as of such earlier date, and except that for purposes of this Section 4.02, the representations and warranties contained in Section 5.08(a) shall be deemed to refer to the
most recent statements furnished pursuant Sections 6.01(a) and (b), respectively. 
 (b) No Default shall exist, or would
result from such proposed Credit Extension. 
 (c) The Administrative Agent, the Canadian Administrative Agent, if applicable, and the L/C
Issuer, if applicable, shall have received a Request for Credit Extension in accordance with the requirements hereof. 
 (d) In the case of
a Drawing Notice or any Loan to be made to McKesson Canada, McKesson Canada shall be a Wholly-Owned Subsidiary. 
 (e) If the applicable
Borrower is a Domestic Borrower pursuant to Section 7.02(d), then the conditions of Section 7.02(d) to the designation of such Borrower as a Domestic Borrower shall have been met to the satisfaction of the Administrative
Agent. 
 (f) In the case of a Drawing Notice, each of the conditions to the acceptance of the Draft identified in such Drawing Notice that
is set forth in Section 2.04 shall have been satisfied. 
 Each Request for Credit Extension (other than a Committed Loan Notice
requesting only a conversion of Committed Loans to the other Type or a continuation of Eurodollar Rate Loans) submitted by the Company or, in the case of a Canadian Loan or Bankers’ Acceptance, McKesson Canada, shall be deemed to be a
representation and warranty that the conditions specified in Sections 4.02(a), (b) and (d) have been satisfied on and as of the date of the applicable Credit Extension. 

  
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 ARTICLE V 

REPRESENTATIONS AND WARRANTIES 

Each Borrower represents and warrants (which representations and warranties in the case of any Borrower other than the Company shall be
limited to such Borrower and its Subsidiaries and other facts and circumstances known to such Borrower and its Subsidiaries) to the Administrative Agent, the Canadian Administrative Agent and each Lender that: 

5.01 Corporate Existence and Power. The Company and each of its Subsidiaries: 

(a) is duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization; 

(b) has the power and authority and all required governmental licenses, authorizations, consents and approvals to own its assets, carry on its
business and to execute, deliver, and perform its obligations under the Loan Documents to which it is a party; 
 (c) is duly qualified and
is licensed and in good standing under the laws of each jurisdiction where its ownership, lease or operation of property or the conduct of its business requires such qualification or license; and 

(d) is in compliance with all Requirements of Law; 

except, (i) with respect to Subsidiaries other than Material Subsidiaries, to the extent that the failure to do so could not reasonably be expected to
have a Material Adverse Effect, and (ii) with respect to the Company and its Material Subsidiaries in each case referred to in clause (c) or clause (d), to the extent that the failure to do so could not reasonably be expected
to have a Material Adverse Effect. 
 5.02 Corporate Authorization; No Contravention. The execution, delivery and performance by Each Borrower of
this Agreement and each other Loan Document to which such Borrower is party, and any Borrowing as of the date of such Borrowing have been duly authorized by all necessary corporate action, and do not and will not: 

(a) contravene the terms of any Borrower’s Organization Documents; 

(b) conflict with or result in any breach or contravention of, or the creation of any Lien under, any document evidencing any Contractual
Obligation to which any Borrower is a party or any order, injunction, writ or decree of any Governmental Authority to which any Borrower or its property is subject; or 

(c) violate any Requirement of Law. 
 5.03
Governmental Authorization. No approval, consent, exemption, authorization, or other action by, or notice to, or filing with, any Governmental Authority is necessary or required in connection with the execution, delivery or performance by, or
enforcement against, any Borrower of the Agreement or any other Loan Document. 
 5.04 Binding Effect. This Agreement and each other Loan Document to
which each Borrower is a party constitute the legal, valid and binding obligations of such Borrower, enforceable against such Borrower in accordance with their respective terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, or similar laws affecting the enforcement of creditors’ rights generally or by equitable principles relating to enforceability. 

  
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 5.05 Litigation. There are no actions, suits, proceedings, claims or disputes pending, or to the best
knowledge of each Borrower, threatened or contemplated, at law, in equity, in arbitration or before any Governmental Authority, against any Borrower, or its Subsidiaries or any of their respective properties which: 

(a) purport to affect or pertain to this Agreement or any other Loan Document, or any of the transactions contemplated hereby or thereby; or

 (b) if determined adversely to the Company or its Subsidiaries, would reasonably be expected to have a Material Adverse Effect as of the
date hereof. No injunction, writ, temporary restraining order or any order of any nature has been issued by any court or other Governmental Authority purporting to enjoin or restrain the execution, delivery or performance of this Agreement or any
other Loan Document, or directing that the transactions provided for herein or therein not be consummated as herein or therein provided . 
 5.06 No
Default. No Default or Event of Default exists or would result from the incurring of any Obligations by any Borrower. As of the date hereof, neither the Company nor any Subsidiary is in default under or with respect to any Contractual Obligation
in any respect which, individually or together with all such defaults, could reasonably be expected to have a Material Adverse Effect as of the date hereof, or that would, if such default had occurred after the date hereof, create an Event of
Default under Section 8.01(e). 
 5.07 Use of Proceeds; Margin Regulations. The proceeds of the Loans are to be used solely for the
purposes set forth in Section 6.10. Neither the Company nor any Subsidiary is generally engaged in the business of purchasing or selling Margin Stock or extending credit for the purpose of purchasing or carrying Margin Stock. 

5.08 Financial Condition. (a) The Audited Financial Statements: 

(A) were prepared in accordance with GAAP consistently applied throughout the period covered thereby, except as otherwise expressly noted
therein, subject in the case of the unaudited statements to ordinary, good faith year end audit adjustments; 
 (B) fairly present the
financial condition of the Company and its Subsidiaries as of the date thereof and results of operations for the period covered thereby; and 

(C) show all material indebtedness and other liabilities, direct or contingent, of the Company and its consolidated Subsidiaries as of the
date thereof required to be shown in accordance with GAAP. 
 (b) As of the date hereof, since March 31, 2011, there has been no
Material Adverse Effect. 
 5.09 Regulated Entities. None of the Company, any Person controlling the Company, or any Subsidiary, is or is required to
be registered as an “investment company” within the meaning of the Investment Company Act of 1940. No Borrower is subject to regulation under the Public Utility Holding Company Act of 1935, the Federal Power Act, the Interstate Commerce
Act, any state public utilities code, or any other Federal, state or other statute or regulation limiting its ability to incur Indebtedness. 
 5.10 No
Burdensome Restrictions. Neither the Company nor any Subsidiary is a party to or bound by any Contractual Obligation, or subject to any restriction in any Organization Document, or any Requirement of Law, which could reasonably be expected to
have a Material Adverse Effect. 

  
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 5.11 Subsidiaries. As of the date hereof, the Company has no Subsidiaries other than those listed on
Schedule 5.11 hereto. 
 5.12 Secured Indebtedness. As of the date hereof, Schedule 5.12 describes all outstanding Indebtedness of the
Company and its Subsidiaries for borrowed money in excess of $25,000,000 that is secured by a Lien existing on property of the Company or any of its Subsidiaries. 

5.13 Taxes. The Borrower and its Subsidiaries have timely filed or caused to be filed all Federal income tax returns and other material tax returns and
reports required to be filed, and have paid all Federal and other material taxes, assessments, fees and other governmental charges levied or imposed upon them or their properties, income or assets otherwise due and payable, except those which are
being contested in good faith by appropriate proceedings diligently conducted and for which adequate reserves have been provided in accordance with GAAP. There is no proposed tax assessment against the Borrower or any Subsidiary that would, if made,
have a Material Adverse Effect. Neither any Borrower nor any Subsidiary thereof is party to any tax sharing agreement other than an agreement solely between one or more Borrowers or Subsidiaries. 

ARTICLE VI 
 AFFIRMATIVE
COVENANTS 
 So long as any Lender shall have any Commitment hereunder, any Loan or other Obligation (other than Obligations under
Section 11.04(b) that remain contingent after termination of the Commitments and payment of all other Obligations) hereunder shall remain unpaid or unsatisfied, or any Letter of Credit or Bankers’ Acceptance shall remain
outstanding, unless the Required Lenders waive compliance in writing: 
 6.01 Financial Statements. The Company shall deliver to the Administrative
Agent, in form and detail satisfactory to the Administrative Agent and the Required Lenders: 
 (a) as soon as available, but in any event
within 70 days after the end of each fiscal year of the Company, a consolidated balance sheet of the Company and its Subsidiaries as at the end of such fiscal year, and the related consolidated statements of operations, shareholders’ equity and
cash flows for such fiscal year, setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail and prepared in accordance with GAAP, audited and accompanied by a report and opinion of
Deloitte & Touche LLP or another nationally recognized independent certified public accountant, which report and opinion shall be prepared in accordance with GAAP and shall not be subject to any “going concern” or like
qualification or exception or any qualification or exception as to the scope of such audit; and 
 (b) as soon as available, but in any
event within 55 days after the end of each of the first three fiscal quarters of each fiscal year of the Company, beginning with the fiscal quarter ending September 30, 2011, a consolidated balance sheet of the Company and its Subsidiaries as
at the end of such fiscal quarter, and the related consolidated statements of operations, shareholders’ equity and cash flows for such fiscal quarter and for the portion of the Company’s fiscal year then ended, setting forth in each case
in comparative form the figures for the corresponding fiscal quarter of the previous fiscal year and the corresponding portion of the previous fiscal year, all in reasonable detail and certified by a Responsible Officer of the Company as fairly
presenting the financial condition, results of operations, shareholders’ equity and cash flows of the Company and its Subsidiaries in accordance with GAAP, subject only to 

  
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normal year-end audit adjustments and the absence of footnotes. As to any information contained in materials furnished pursuant to Section 6.02(b), the Company shall not be separately
required to furnish such information under clause (a) or (b) above, but the foregoing shall not be in derogation of the obligation of the Company to furnish the information and materials described in Sections 6.01(a) and (b) at
the times specified therein. 
 6.02 Certificates; Other Information. The Company shall deliver to the Administrative Agent: 

(a) concurrently with the delivery of the financial statements referred to in Sections 6.01(a) and (b), a duly completed
Compliance Certificate signed by a Responsible Officer of the Company; 
 (b) promptly after the same are available, copies of each annual
report, proxy or financial statement or other report or communication sent to the stockholders of the Company, and copies of all annual, regular, periodic and special reports and registration statements which the Company may file or be required to
file with the SEC under Section 13 or 15(d) of the Securities Exchange Act of 1934, and not otherwise required to be delivered to the Administrative Agent pursuant hereto; and 

(c) promptly, such additional information regarding the business, financial or corporate affairs of the Borrowers or any Subsidiary, or
compliance with the terms of the Loan Documents, as the Administrative Agent or any Lender may from time to time reasonably request. 

Documents required to be delivered pursuant to Section 6.01(a) or (b) or Section 6.02(b) may be delivered
electronically and if so delivered, shall be deemed to have been delivered on the date (i) on which it is publicly available at no charge on the EDGAR system of the United States Securities and Exchange Commission, (ii) on which the
Company posts such documents, or provides a link thereto on the Company’s website on the Internet at the website address listed on Schedule 11.02; or (iii) on which such documents are posted on the Company’s behalf on
IntraLinks or another similar electronic system (a “Platform”), if any, to which each Lender and the Administrative Agent have access (whether a commercial, third-party website or whether sponsored by the Administrative Agent). The
Administrative Agent shall have no obligation to request the delivery or to maintain copies of the documents referred to above, and in any event shall have no responsibility to monitor compliance by the Company with any such request for delivery,
and each Lender shall be solely responsible for requesting delivery to it or maintaining its copies of such documents. 
 The Borrower
hereby acknowledges that (a) the Administrative Agent may make available to the Lenders and the L/C Issuer materials and/or information provided by or on behalf of the Borrower under Sections 6.01(a), 6.01(b), 6.02(a) and
6.02(b) (and any other such materials and/or information to the extent the Borrower has previously consented in writing) (collectively, “Borrower Materials”) by posting the Borrower Materials on a Platform and
(b) certain of the Lenders (each, a “Public Lender”) may have personnel who do not wish to receive material non-public information with respect to the Borrower or its affiliates, or the respective securities of any of the foregoing,
and who may be engaged in investment and other market-related activities with respect to such Persons’ securities. The Borrower hereby agrees that (a) all Borrower Materials that are to be made available to Public Lenders shall be clearly
and conspicuously marked “PUBLIC” which, at a minimum, shall mean that the word “PUBLIC” shall appear prominently on the first page thereof; (b) by marking Borrower Materials “PUBLIC,” the Borrower shall be deemed
to have authorized the Administrative Agent, the L/C Issuer and the Lenders to treat such 

  
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Borrower Materials as publicly available information with respect to the Borrower or its securities for purposes of United States Federal and state securities laws; (c) all Borrower
Materials marked “PUBLIC” are permitted to be made available through a portion of a Platform designated “Public Investor”; and (d) the Administrative Agent shall be entitled to treat any Borrower Materials that are not
marked “PUBLIC” as being suitable only for posting on a portion of a Platform not designated “Public Investor”. 
 6.03 Notices.
Each Borrower shall promptly notify the Administrative Agent: 
 (a) of the occurrence of any Default; 

(b) of any matter that has resulted or could reasonably be expected to result in a Material Adverse Effect; 

(c) promptly upon any Responsible Officer of the Company obtaining knowledge thereof of (i) the institution of, or non-frivolous threat
of, any action, suit, proceeding (whether administrative, judicial or otherwise), governmental investigation or arbitration against or affecting any Borrower or any of its Subsidiaries or any property of any Borrower or any of its Subsidiaries
(collectively “Proceedings”) not previously disclosed in writing by the Company to the Lenders or (ii) any material development in any Proceeding that, in the case of clause (i) or (ii) above, (A) has a
reasonable possibility of giving rise to a Material Adverse Effect; or (B) seeks to enjoin or otherwise prevent the consummation of, or to recover any damages or obtain relief as a result of, the transactions contemplated hereby, together with
such other information as may be reasonably available to Company that the Administrative Agent requests to enable the Administrative Agent and the Lenders to evaluate such matters. 

(d) of any material change in accounting policies or financial reporting practices by any Borrower or any Subsidiary; 

(e) of any announcement by S&P, Moody’s or Fitch of any change or possible change in a Debt Rating; and 

(f) of (i) the occurrence of any ERISA Event with respect to a Pension Plan or Multiemployer Plan which has resulted or could reasonably
be expected to result in liability of any Borrower or any of its Subsidiaries in an aggregate amount in excess of $50,000,000 during the term of this Agreement, or (ii) the existence of an amount of unfunded benefit liabilities (as defined in
Section 4001(a)(18) of ERISA), individually or in the aggregate for all Pension Plans (excluding for purposes of such computation any Pension Plans with respect to which assets exceed benefit liabilities), which exceeds 3% of Net Worth. 

Notification delivered to the Administrative Agent and each Lender by any Borrower under this Section 6.03 shall satisfy the
notice obligation of all Borrowers hereunder. Each notice pursuant to this Section 6.03 shall be accompanied by a statement of a Responsible Officer of the Company setting forth details of the occurrence referred to therein and stating
what action the Company has taken and proposes to take with respect thereto. Each notice pursuant to Section 6.03(a) shall describe with particularity any and all provisions of this Agreement and any other Loan Document that have been
breached. 
 6.04 Preservation of Existence, Etc. Each Borrower shall, and shall cause each of its Material Subsidiaries to, (a) preserve, renew
and maintain in full force and effect its legal existence and good standing under the Laws of the jurisdiction of its organization except in a transaction permitted by Section 7.02 

  
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and (b) take all reasonable action to maintain all governmental rights, privileges, permits, licenses and franchises necessary in the normal conduct of its business, except in connection
with transactions permitted by Section 7.02 and except to the extent that failure to do so could not reasonably be expected to have a Material Adverse Effect. 

6.05 Maintenance of Insurance. Each Borrower shall, and shall cause each of its Material Subsidiaries to, maintain with financially sound and reputable
insurance companies, insurance (including self-insurance) with respect to its properties and business against loss or damage of the kinds customarily insured against by Persons engaged in the same or similar business, of such types and in such
amounts as the Company reasonably deems prudent from time to time. 
 6.06 Payment of Taxes. Each Borrower shall, and shall cause each of its
Material Subsidiaries to, pay and discharge as the same shall become due and payable, all tax liabilities, assessments and governmental charges or levies upon it or its properties or assets (other than obligations that a Responsible Officer is not
aware of or are of a nominal amount), unless the same are being contested in good faith by appropriate proceedings diligently conducted and adequate reserves in accordance with GAAP are being maintained by the Company or such Material Subsidiary.

 6.07 Compliance with Laws. Each Borrower shall, and shall cause each of its Material Subsidiaries to, comply in all material respects with the
Requirements of Law applicable to it or to its business, except in such instances in which (a) a Requirement of Law is being contested in good faith by appropriate proceedings diligently conducted; or (b) the failure to comply therewith
could not reasonably be expected to have a Material Adverse Effect. 
 6.08 Books and Records. Each Borrower shall, and shall cause each of its
Material Subsidiaries to, maintain in all material respects proper books of record and account, in which full, true and correct entries in conformity with GAAP consistently applied shall be made of all financial transactions and matters involving
the assets and business of the Company and such Material Subsidiary, as the case may be. 
 6.09 Inspection Rights. Each Borrower shall, and shall
cause each of its Material Subsidiaries to, permit representatives and independent contractors of the Administrative Agent and each Lender to visit and inspect any of its properties, to examine its corporate, financial and operating records, and
make copies thereof or abstracts therefrom, and to discuss its affairs, finances and accounts with its directors, officers, and independent public accountants, all at such reasonable times during normal business hours and as often as may be
reasonably desired, upon reasonable advance notice to the Company; provided, however, that when an Event of Default exists the Administrative Agent or any Lender (or any of their respective representatives or independent contractors)
may do any of the foregoing at the reasonable expense of the Borrowers at any time during normal business hours and without advance notice. 
 6.10 Use
of Proceeds. The Borrowers shall use the proceeds of the Credit Extensions for general corporate purposes (including the refinancing of existing indebtedness and acquisitions) not in contravention of any Law or of any Loan Document. 

  
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 ARTICLE VII 

NEGATIVE COVENANTS 
 So
long as any Lender shall have any Commitment hereunder, any Loan or other Obligation (other than Obligations under subsection 11.04(b) that remain contingent after termination of the Commitments and payment of all other Obligations) hereunder
shall remain unpaid or unsatisfied, or any Letter of Credit or Bankers’ Acceptance shall remain outstanding, unless the Required Lenders waive compliance in writing: 

7.01 Liens. No Borrower shall, or shall suffer or permit any of its Subsidiaries to, directly or indirectly, create, incur, assume or suffer to exist
any Lien upon any of its property, whether now owned or hereafter acquired, other than the following (“Permitted Liens”): 

(a) any Lien existing on property of the Company or any Subsidiary on the date hereof securing Indebtedness outstanding on such date; 

(b) any Lien created under any Loan Document; 

(c) Liens for taxes, fees, assessments or other governmental charges not yet due or which are being contested in good faith and by appropriate
proceedings diligently conducted, if adequate reserves with respect thereto are maintained on the books of the applicable Person in accordance with GAAP; 

(d) carriers’, warehousemen’s, mechanics’, materialmen’s, landlords’, repairmen’s or other like Liens arising in
the ordinary course of business which are not delinquent or remain payable without penalty; 
 (e) pledges or deposits required in the
ordinary course of business in connection with workers’ compensation, unemployment insurance and other social security legislation, other than any Lien imposed by ERISA; 

(f) Liens on the property of the Company or any Subsidiary securing (i) the non-delinquent performance of bids, trade contracts (other
than for borrowed money), leases, statutory obligations, (ii) contingent obligations on surety and appeal bonds, and (iii) other non-delinquent obligations of a like nature; in each case, incurred in the ordinary course of business,
provided all such Liens in the aggregate would not (even if enforced) cause a Material Adverse Effect; 
 (g) easements, rights-of-way,
restrictions and other similar encumbrances which, in the aggregate, are not substantial in amount, and which do not in any case materially detract from the value of the property subject thereto or materially interfere with the ordinary conduct of
the business of the applicable Person; 
 (h) Liens arising solely by virtue of any statutory or common law provision relating to
banker’s liens, rights of set-off or similar rights and remedies as to deposit accounts or other funds maintained with a creditor depository institution; provided that (i) such deposit account is not a dedicated cash collateral
account and is not subject to restrictions against access by the Company in excess of those set forth by regulations promulgated by the FRB, and (ii) such deposit account is not intended by the Company or any Subsidiary to provide collateral to
the depository institution; 
 (i) Liens arising out of any Qualified Receivables Transaction; and 

  
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 (j) Liens securing Indebtedness and other obligations (other than Indebtedness and other
obligations secured by Liens described in any of the foregoing Sections 7.01(a) through (i)) in an aggregate principal amount not exceeding at any time $2,000,000,000. 

7.02 Consolidations and Mergers. The Company shall not, and shall not suffer or permit any of its Material Subsidiaries to, directly or indirectly,
liquidate, dissolve, merge, amalgamate, consolidate with or into, or convey, transfer, lease or otherwise dispose of (whether in one transaction or in a series of transactions) all or substantially all of its assets (whether now owned or hereafter
acquired) to or in favor of any Person, except: 
 (a) any Subsidiary may merge with the Company, provided that the Company shall be the
continuing or surviving corporation, or with any one or more Subsidiaries, provided that if any transaction shall be between a Subsidiary and a Wholly-Owned Subsidiary, the Wholly-Owned Subsidiary shall be the continuing or surviving corporation;

 (b) McKesson Canada or any Subsidiary of McKesson Canada may amalgamate with McKesson Canada or with any one or more of the
Company’s Subsidiaries and any of the Company’s Subsidiaries may amalgamate with any one or more of the Company’s Subsidiaries; 

(c) any Subsidiary may sell, transfer or exchange all or substantially all of its assets (upon voluntary liquidation or otherwise) to the
Company or a Wholly-Owned Subsidiary; 
 (d) the Company may convey, transfer, lease or otherwise dispose of all or substantially all of its
pharmacology distribution business to a wholly-owned Domestic Subsidiary that, simultaneously therewith, executes and delivers to the Administrative Agent a joinder agreement in the form of Exhibit F hereto and becomes a Domestic Borrower
under this Agreement; provided that the parties hereto acknowledge and agree that prior to such Domestic Borrower becoming entitled to utilize the credit facilities provided for herein the Administrative Agent and the Lenders shall have
received such supporting resolutions, incumbency certificates, opinions of counsel and other documents or information, in form, content and scope reasonably satisfactory to the Administrative Agent, as may reasonably be required by the
Administrative Agent or the Required Lenders, and Notes signed by such new Domestic Borrower to the extent any Lenders so require. If the Administrative Agent and the Required Lenders agree that such Domestic Borrower shall be entitled to receive
Loans hereunder, then promptly following receipt of all such requested resolutions, incumbency certificates, opinions of counsel and other documents or information, the Administrative Agent shall send a notice in substantially the form of
Exhibit G (a “Domestic Borrower Notice”) to the Company and the Lenders specifying the effective date upon which such Domestic Borrower shall constitute a Domestic Borrower for purposes hereof, whereupon each of the
Lenders agrees to permit such Domestic Borrower to receive Loans hereunder, on the terms and conditions set forth herein, and each of the parties agrees that such Domestic Borrower otherwise shall be a Borrower for all purposes of this Agreement;
provided that no Committed Loan Notice or Letter of Credit Application may be submitted by or on behalf of such Domestic Borrower until the date five Business Days after such effective date; and 

(e) the Company may merge or consolidate with or into another Person, provided that (i) either (x) the Company shall be the
continuing or surviving corporation or (y) (A) the successor Person (if other than the Company) formed by such consolidation or into which the 

  
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Company is merged (the “Successor”) is a corporation, limited liability company or limited partnership organized or existing under the laws of the United States, any state of the
United States or the District of Columbia, and (B) the Successor (if any) shall have expressly assumed all of the Company’s Obligations pursuant to documentation in form satisfactory to the Administrative Agent, and (ii) no Default or
Event of Default is in effect immediately prior to or on the date of or would result from such merger or consolidation. 
 7.03 Use of Proceeds. No
Borrower shall, or shall suffer or permit any of its Subsidiaries to, use any Credit Extension, directly or indirectly, (a) to purchase or carry Margin Stock in contravention of Regulation U issued by the Board of Governors of the Federal
Reserve, (b) to repay or otherwise refinance indebtedness of the Company or others incurred to purchase or carry Margin Stock in contravention of said Regulation U, (c) to extend credit for the purpose of purchasing or carrying any Margin
Stock in contravention of said Regulation U, or (d) to acquire any security in any transaction that is subject to Section 13 or 14 of the Securities Exchange Act of 1934, in contravention of said Regulation U. 

7.04 Maximum Debt to Capitalization Ratio. The Company shall not permit the ratio of Total Debt to Total Capitalization as at the last day of any
calendar month to exceed 0.565 to 1.00. 
 7.05 Swap Contracts. No Borrower shall, or shall suffer or permit any of its Subsidiaries to, enter into
Swap Contracts other than in the ordinary course of business and for the purpose of hedging an existing or anticipated underlying agreement. 

ARTICLE VIII 
 EVENTS OF
DEFAULT AND REMEDIES 
 8.01 Events of Default. Any of the following shall constitute an Event of Default: 

(a) Non-Payment. Any Borrower fails to pay (i) when and as required to be paid herein, any amount of principal of any Loan, L/C
Obligation or Bankers’ Acceptance, or (ii) within five days after the same becomes due, any interest on any Loan, L/C Obligation or Bankers’ Acceptance, or any facility fee or other fee due hereunder, or any other amount payable
hereunder or under any other Loan Document; or 
 (b) Specific Covenants. The Company fails to perform or observe any term, covenant
or agreement contained in any of Section 6.04(a) or Article VII; or 
 (c) Other Defaults. Any Borrower fails to
perform or observe any other covenant or agreement (not specified in Section 8.01(a) or (b)) contained in any Loan Document on its part to be performed or observed and such failure continues for 30 days after the earlier of
(i) in the case of any provision in Article VI, the date upon which a Responsible Officer knew of such failure or (ii) the date upon which written notice thereof is given to the Company by the Administrative Agent or any Lenders; or

 (d) Representations and Warranties. Any representation, warranty, certification or statement of fact made or deemed made by or on
behalf of any Borrower herein, in any other Loan Document, or in any document delivered in connection herewith or therewith shall be incorrect or misleading in any material respect when made or deemed made; or 

  
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 (e) Cross-Default. (i) The Company or any Subsidiary (A) fails to make any
payment when due (whether by scheduled maturity, required prepayment, acceleration, demand, or otherwise) in respect of any Indebtedness or Guarantee (other than any intercompany Indebtedness or any Indebtedness hereunder or under Swap Contracts)
having an aggregate principal amount (including undrawn committed or available amounts and including amounts owing to all creditors under any combined or syndicated credit arrangement) of more than $100,000,000 (such Indebtedness or Guarantee being
a “Relevant Obligation”) and such failure continues after the applicable grace or notice period, if any, specified in the relevant document on the date of such failure, or (B) fails to observe or perform any other agreement or
condition relating to, or contained in any instrument or agreement evidencing, securing or relating to, any Relevant Obligation, and such failure continues after the applicable grace or notice period, if any, specified in the relevant document on
the date of such failure, or any other event occurs, the effect of which default or other event is to cause, or to permit the holder, holders, beneficiary or beneficiaries (or a trustee or agent on behalf of such holder or holders or beneficiary or
beneficiaries) of such Relevant Obligation to cause, with the giving of notice if required, such Relevant Obligation to be demanded or to become due or to be repurchased, prepaid, defeased or redeemed (automatically or otherwise), or an offer to
repurchase, prepay, defease or redeem such Relevant Obligation to be made, prior to its stated maturity, or such cash collateral in respect of such Relevant Obligation to be demanded (provided that an Acquired Debt Default shall not constitute an
Event of Default pursuant to this clause (i)(B) so long as such Acquired Debt Default is waived or cured, or the Relevant Obligation giving rise thereto is repaid, within 30 days of consummation of the transaction giving rise thereto) or
(ii) there occurs under any Swap Contract an Early Termination Date (as defined in such Swap Contract) resulting from (A) any event of default under such Swap Contract as to which the Company or any Subsidiary is the Defaulting Party (as
defined in such Swap Contract) or (B) any Termination Event (as so defined) under such Swap Contract as to which the Company or any Subsidiary is an Affected Party (as so defined) and, in either event, the Swap Termination Value owed by the
Company or such Subsidiary as a result thereof is greater than $100,000,000; or 
 (f) Insolvency; Voluntary Proceedings. The Company
or any Material Subsidiary (i) ceases or fails to be solvent, or generally fails to pay, or admits in writing its inability to pay, its debts as they become due, subject to applicable grace periods, if any, whether at stated maturity or
otherwise; (ii) voluntarily ceases to conduct its business in the ordinary course; (iii) commences any Insolvency Proceeding with respect to itself; or (iv) takes any action to effectuate or authorize any of the foregoing; or 

(g) Involuntary Proceedings. (i) Any involuntary Insolvency Proceeding is commenced or filed against the Company or any Material
Subsidiary, or any writ, judgment, warrant of attachment, execution or similar process, is issued or levied against a substantial part of the Company’s or any Material Subsidiary’s properties, and any such proceeding or petition shall not
be dismissed, or such writ, judgment, warrant of attachment, execution or similar process shall not be released, vacated or fully bonded within sixty (60) days after commencement, filing or levy; (ii) the Company or any Material Subsidiary
admits the material allegations of a petition against it in any Insolvency Proceeding, or an order for relief (or similar order under non-U.S. law) is ordered in any Insolvency Proceeding; or (iii) the Company or any Material Subsidiary
acquiesces in the appointment of a receiver, trustee, custodian, conservator, liquidator, mortgagee in possession (or agent therefor), or other similar Person for itself or a substantial portion of its property or business; or 

  
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 (h) ERISA. (i) An ERISA Event occurs with respect to a Pension Plan or Multiemployer
Plan which has resulted or could reasonably be expected to result in liability of the Company or any of its Subsidiaries in an aggregate amount in excess of $100,000,000 during the term of this Agreement, or (ii) there shall exist an amount of
unfunded benefit liabilities (as defined in Section 4001(a)(18) of ERISA), individually or in the aggregate for all Pension Plans (excluding for purposes of such computation any Pension Plans with respect to which assets exceed benefit
liabilities), which exceeds 7% of Net Worth; or 
 (i) Invalidity of Loan Documents. Any Loan Document, at any time after its
execution and delivery and for any reason other than as expressly permitted hereunder or thereunder or satisfaction in full of all the Obligations, ceases to be in full force and effect; or any Loan Party contests in any manner the validity or
enforceability of any provision of any Loan Document; or any Loan Party denies that it has any or further liability or obligation under any Loan Document, or purports to revoke, terminate or rescind any provision of any Loan Document; or 

(j) Change of Control. There occurs any Change of Control. 

8.02 Remedies Upon Event of Default. If any Event of Default occurs and is continuing, the Administrative Agent shall, at the request of, or may, with
the consent of, the Required Lenders, take any or all of the following actions: 
 (a) declare the commitment of each Lender to make Loans
and accept Drafts and any obligation of the L/C Issuer to make L/C Credit Extensions to be terminated, whereupon such commitments and obligation shall be terminated; 

(b) declare the unpaid principal amount of all outstanding Loans, all interest accrued and unpaid thereon, and all other amounts owing or
payable hereunder or under any other Loan Document to be immediately due and payable, without presentment, demand, protest or other notice of any kind, all of which are hereby expressly waived by each Borrower; 

(c) require that the Company Cash Collateralize the L/C Obligations and unmatured Bankers’ Acceptances (in an amount equal to the then
Outstanding Amount thereof); and 
 (d) exercise on behalf of itself and the Lenders all rights and remedies available to it and the Lenders
under the Loan Documents or applicable law; 
 provided, however, that upon the occurrence of an actual or deemed entry of an order
for relief with respect to any Borrower under the Bankruptcy Code of the United States, except in the case of Section 8.01(g)(i), in which case upon the expiration of the 60-day period mentioned therein if the curative action mentioned
in such clause is not taken, the obligation of each Lender to make Loans and accept or discount Drafts or Bankers’ Acceptances and any obligation of the L/C Issuer to make L/C Credit Extensions shall automatically terminate, the unpaid
principal amount of all outstanding Loans and all interest and other amounts as aforesaid shall automatically become due and payable, and the obligation of the Company to Cash Collateralize the L/C Obligations and Bankers’ Acceptances as
aforesaid shall automatically become effective, in each case without further act of the Administrative Agent or any Lender. 

  
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 8.03 Application of Funds. After the exercise of remedies provided for in Section 8.02 (or
after the Loans and other Obligations have automatically become immediately due and payable and the L/C Obligations and Bankers’ Acceptances have automatically been required to be Cash Collateralized as set forth in the proviso to
Section 8.02), any amounts received on account of the Obligations shall be applied by the Administrative Agent in the following order: 

First, to payment of that portion of the Obligations constituting fees, indemnities, expenses and other amounts (including Attorney
Costs and amounts payable under Article III) payable to the Administrative Agent, the Canadian Administrative Agent and the L/C Issuer in their respective capacities as such; 

Second, to payment of that portion of the Obligations constituting fees, indemnities and other amounts (other than principal and
interest) payable to the Lenders (including Attorney Costs and amounts payable under Article III), ratably among them in proportion to the amounts described in this clause Second payable to them; 

Third, to payment of that portion of the Obligations constituting accrued and unpaid interest on the Loans and L/C Borrowings, ratably
among the Lenders in proportion to the respective amounts described in this clause Third payable to them; 
 Fourth, to
payment of that portion of the Obligations constituting unpaid principal of the Loans and L/C Borrowings, in each case ratably among the Lenders in proportion to the respective amounts described in this clause Fourth held by them; 

Fifth, to the Administrative Agent for the account of the L/C Issuer, and to the Canadian Administrative Agent for the account of the
applicable Canadian Lenders, to Cash Collateralize that portion of L/C Obligations comprised of the aggregate undrawn amount of Letters of Credit and that portion of the Obligations constituting unpaid principal of the Bankers’ Acceptances; and

 Last, the balance, if any, after all of the Obligations have been indefeasibly paid in full, to the Applicable Borrower or as
otherwise required by Law. 
 Subject to Section 2.03(c), amounts used to Cash Collateralize the aggregate undrawn amount of
Letters of Credit or the unmatured Bankers’ Acceptances pursuant to clause Fifth above shall be applied to satisfy drawings under such Letters of Credit as they occur and Bankers’ Acceptances as they mature. If any amount remains on
deposit as Cash Collateral after all Letters of Credit have either been fully drawn or expired and all Bankers’ Acceptances have been paid, such remaining amount shall be applied to the other Obligations, if any, in the order set forth above.

 ARTICLE IX 

ADMINISTRATIVE AGENT 
 9.01 Appointment
and Authorization of Agents. 
 (a) Each of the Lenders and the L/C Issuer hereby irrevocably appoints Bank of America to act on its
behalf as the Administrative Agent hereunder and under the other Loan Documents, and each Canadian Lender hereby irrevocably appoints BA Canada to act on its behalf as the Canadian Administrative Agent hereunder and under the other Loan Documents,

  
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and authorizes each such Agent to take such actions on its behalf under the provisions of this Agreement and each other Loan Document and to exercise such powers as are delegated to such Agent by
the terms hereof or thereof, together with such actions and powers as are reasonably incidental thereto. The provisions of this Article IX are solely for the benefit of the Administrative Agent, the Canadian Administrative Agent, the Lenders
and the L/C Issuer, and the Borrowers shall not have rights as a third party beneficiary of any of such provisions other than the provisions of Section 9.06 relating to the Company’s consultation and notice rights. 

(b) Notwithstanding any provision to the contrary contained elsewhere herein or in any other Loan Document, no Agent shall have any duties or
responsibilities, except those expressly set forth herein, nor shall either Agent have or be deemed to have any fiduciary relationship with any Lender or participant, and no implied covenants, functions, responsibilities, duties, obligations or
liabilities shall be read into this Agreement or any other Loan Document or otherwise exist against either Agent. Without limiting the generality of the foregoing sentence, the use of the term “agent” herein and in the other Loan Documents
with reference to the Administrative Agent and the Canadian Administrative Agent is not intended to connote any fiduciary or other implied (or express) obligations arising under agency doctrine of any applicable Law. Instead, such term is used
merely as a matter of market custom, and is intended to create or reflect only an administrative relationship between independent contracting parties. 

(c) The L/C Issuer shall act on behalf of the Lenders with respect to any Letters of Credit issued by it and the documents associated
therewith, and the L/C Issuer shall have all of the benefits and immunities (A) provided to the Administrative Agent in this Article IX with respect to any acts taken or omissions suffered by the L/C Issuer in connection with Letters of
Credit issued by it or proposed to be issued by it and the Issuer Documents pertaining to such Letters of Credit as fully as if the term “Administrative Agent” as used in this Article IX included the L/C Issuer with respect to such
acts or omissions, and (B) as additionally provided herein with respect to the L/C Issuer. 
 9.02 Rights as a Lender. The Person serving as the
Administrative Agent and the Person serving as Canadian Administrative Agent hereunder shall have the same rights and powers in its capacity as a Lender as any other Lender (and, as applicable, in its capacity as a Canadian Lender as any other
Canadian Lender) and may exercise the same as though it were not such Agent and the term “Lender” or “Lenders” (and, as applicable, the term “Canadian Lender” or “Canadian Lenders”) shall, unless otherwise
expressly indicated or unless the context otherwise requires, include the Person serving as the Administrative Agent hereunder and the Person serving as the Canadian Administrative Agent hereunder in their respective individual capacities. Each such
Person and its Affiliates may accept deposits from, lend money to, act as the financial advisor or in any other advisory capacity for and generally engage in any kind of business with the Borrowers or any Subsidiary or other Affiliate thereof as if
such Persons were not Agents hereunder and without any duty to account therefor to the Lenders. 
 9.03 Exculpatory Provisions. Neither Agent shall
have any duties or obligations except those expressly set forth herein and in the other Loan Documents. Without limiting the generality of the foregoing, neither Agent: 

(a) shall be subject to any fiduciary or other implied duties, regardless of whether a Default has occurred and is continuing; 

  
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 (b) shall have any duty to take any discretionary action or exercise any discretionary powers,
except discretionary rights and powers expressly contemplated hereby or by the other Loan Documents that such Agent is required to exercise as directed in writing by the Required Lenders (or such other number or percentage of the Lenders as shall be
expressly provided for herein or in the other Loan Documents), provided that neither Agent shall be required to take any action that, in its opinion or the opinion of its counsel, may expose such Agent to liability or that is contrary to any
Loan Document or applicable law; and 
 (c) shall, except as expressly set forth herein and in the other Loan Documents, have any duty to
disclose, and shall be liable for the failure to disclose, any information relating to the Borrowers or any of their Affiliates that is communicated to or obtained by the Person serving as such Agent or any of its Affiliates in any capacity. 

Neither Agent shall be liable for any action taken or not taken by it (i) with the consent or at the request of the Required Lenders (or
such other number or percentage of the Lenders as shall be necessary, or as such Agent shall believe in good faith shall be necessary, under the circumstances as provided in Sections 11.01 and 8.02) or (ii) in the absence of its
own gross negligence or willful misconduct. Neither Agent shall be deemed to have knowledge of any Default unless and until notice describing such Default is given to such Agent by a Borrower, a Lender or the L/C Issuer. 

Neither Agent shall be responsible for or have any duty to ascertain or inquire into (i) any statement, warranty or representation made
in or in connection with this Agreement or any other Loan Document, (ii) the contents of any certificate, report or other document delivered hereunder or thereunder or in connection herewith or therewith, (iii) the performance or
observance of any of the covenants, agreements or other terms or conditions set forth herein or therein or the occurrence of any Default, (iv) the validity, enforceability, effectiveness or genuineness of this Agreement, any other Loan Document
or any other agreement, instrument or document or (v) the satisfaction of any condition set forth in Article IV or elsewhere herein, other than to confirm receipt of items expressly required to be delivered to such Agent. 

9.04 Delegation of Duties. Each Agent may perform any and all of its duties and exercise its rights and powers hereunder or any other Loan Document by
or through any one or more sub-agents appointed by such Agent. Each Agent and any such sub-agent may perform any and all of its duties and exercise its rights and powers by or through their respective Related Parties. The exculpatory provisions of
this Article shall apply to any such sub-agent and to the Related Parties of the Agents and any such sub-agent, and shall apply to their respective activities in connection with the syndication of the credit facilities provided for herein as well as
activities as Administrative Agent and Canadian Administrative Agent. 
 9.05 Reliance by Agents. Each Agent shall be entitled to rely upon, and
shall not incur any liability for relying upon, any notice, request, certificate, consent, statement, instrument, document or other writing (including any electronic message, internet or intranet website posting or other distribution) believed by it
to be genuine and to have been signed, sent or otherwise authenticated by the proper Person or Persons. Each Agent also may rely upon any statement made to it orally or by telephone and believed by it to have been made by the proper Person, and
shall not incur any liability for relying thereon. In determining compliance with any condition hereunder to the making of a Loan, or the issuance of a Letter of Credit, that by its terms must be fulfilled to the satisfaction of a Lender or the L/C
Issuer, each Agent may presume that such condition is satisfactory to such Lender or the L/C Issuer unless such Agent shall have received notice to the contrary from such Lender or the L/C Issuer prior to the making of such Loan or the issuance of
such Letter of Credit. Each Agent may consult with legal counsel (who may be counsel for the Borrower), independent accountants and other experts selected by it, and shall not be liable for any action taken or not taken by it in accordance with the
advice of any such counsel, accountants or experts. 

  
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 9.06 Successor Agents. Either Agent may at any time give notice of its resignation to the Lenders, the L/C
Issuer and the Company. Upon receipt of any such notice of resignation, the Required Lenders shall have the right, in consultation with the Company, to appoint a successor, which, in the case of the Administrative Agent, shall be a bank with an
office in the United States, or an Affiliate of any such bank with an office in the United States and, in the case of the Canadian Administrative Agent, shall be a bank with an office in Canada, or an Affiliate of any such bank with an office in
Canada. If no such successor shall have been so appointed by the Required Lenders and shall have accepted such appointment within 30 days after the retiring Agent gives notice of its resignation, then the retiring Agent may on behalf of the Lenders
and the L/C Issuer (if applicable) appoint a successor Agent meeting the qualifications set forth above; provided that if the Applicable Agent shall notify the Company and the Lenders that no qualifying Person has accepted such appointment,
then such resignation shall nonetheless become effective in accordance with such notice and (a) the retiring Agent shall be discharged from its duties and obligations hereunder and under the other Loan Documents and (b) all payments,
communications and determinations provided to be made by, to or through such Agent shall instead be made by or to each Lender and the L/C Issuer directly, until such time as the Required Lenders appoint a successor Agent as provided for above in
this Section. Upon the acceptance of a successor’s appointment as Administrative Agent or Canadian Administrative Agent hereunder, such successor shall succeed to and become vested with all of the rights, powers, privileges and duties of the
retiring (or retired) Administrative Agent or Canadian Administrative Agent, as applicable, and the retiring Agent shall be discharged from all of its duties and obligations hereunder or under the other Loan Documents (if not already discharged
therefrom as provided above in this Section). The fees payable by the Company to a successor Agent shall be the same as those payable to its predecessor unless otherwise agreed between the Company and such successor. After the retiring
Administrative Agent’s or Canadian Administrative Agent’s resignation hereunder and under the other Loan Documents, the provisions of this Article and Section 11.04 shall continue in effect for the benefit of such retiring
Agent, its sub-agents and their respective Related Parties in respect of any actions taken or omitted to be taken by any of them while the retiring Agent was acting as such Agent. 

9.07 Non-Reliance on Agents and Other Lenders. Each Lender and the L/C Issuer acknowledges that it has, independently and without reliance upon the
Administrative Agent, the Canadian Administrative Agent or any other Lender or any of their Related Parties and based on such documents and information as it has deemed appropriate, made its own credit analysis and decision to enter into this
Agreement. Each Lender and the L/C Issuer also acknowledges that it will, independently and without reliance upon either Agent or any other Lender or any of their Related Parties and based on such documents and information as it shall from time to
time deem appropriate, continue to make its own decisions in taking or not taking action under or based upon this Agreement, any other Loan Document or any related agreement or any document furnished hereunder or thereunder. 

9.08 No Other Duties, Etc. Anything herein to the contrary notwithstanding, none of the documentation agents, syndication agents, book managers or
arrangers listed on the cover page hereof shall have any powers, duties or responsibilities under this Agreement or any of the other Loan Documents, except in its capacity, as applicable, as the Administrative Agent or a Lender hereunder. Without
limiting the foregoing, none of the Lenders or other Persons so listed shall have or be deemed to have any fiduciary relationship with any Lender. Each Lender acknowledges that it has not relied, and will not rely, on any of the Lenders or other
Persons so listed in deciding to enter into this Agreement or in taking or not taking action hereunder. 
 9.09 Administrative Agent May File Proofs of
Claim. In case of the pendency of any proceeding under any Debtor Relief Law or any other judicial proceeding relative to any Loan Party, the 

  
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Administrative Agent (irrespective of whether the principal of any Loan, Bankers’ Acceptance or L/C Obligation shall then be due and payable as herein expressed or by declaration or
otherwise and irrespective of whether the Administrative Agent shall have made any demand on any Borrower) shall be entitled and empowered, by intervention in such proceeding or otherwise: 

(a) to file and prove a claim for the whole amount of the principal and interest owing and unpaid in respect of the Loans, L/C Obligations and
all other Obligations that are owing and unpaid and to file such other documents as may be necessary or advisable in order to have the claims of the Lenders and the Administrative Agent (including any claim for the reasonable compensation, expenses,
disbursements and advances of the Lenders and the Administrative Agent and their respective agents and counsel and all other amounts due the Lenders and the Administrative Agent under Sections 2.03(i) and (j), 2.09 and
11.04) allowed in such judicial proceeding; and 
 (b) to collect and receive any monies or other property payable or deliverable on
any such claims and to distribute the same; and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in any such judicial proceeding is hereby authorized by each Lender to make such payments to the
Administrative Agent and, in the event that the Administrative Agent shall consent to the making of such payments directly to the Lenders, to pay to the Administrative Agent any amount due for the reasonable compensation, expenses, disbursements and
advances of the Administrative Agent and its agents and counsel, and any other amounts due the Administrative Agent under Sections 2.09 and 11.04. 

Nothing contained herein shall be deemed to authorize the Administrative Agent to authorize or consent to or accept or adopt on behalf of any
Lender any plan of reorganization, arrangement, adjustment or composition affecting the Obligations or the rights of any Lender or to authorize the Administrative Agent to vote in respect of the claim of any Lender in any such proceeding. 

ARTICLE X 
 THE
COMPANY’S GUARANTY OF OTHER BORROWERS’ OBLIGATIONS 
 10.01 Guaranty of the Guarantied Obligations. The Company hereby irrevocably and
unconditionally guaranties, as primary obligor and not merely as surety, the due and punctual payment in full of all Guarantied Obligations when the same shall become due, whether at stated maturity, by required prepayment, declaration,
acceleration, demand or otherwise (including amounts that would become due but for the operation of the automatic stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C. § 362(a)). The term “Guarantied
Obligations” is used herein in its most comprehensive sense and includes: 
 (a) any and all Obligations of each other Borrower
(each, a “Guarantied Borrower”) now or hereafter made, incurred or created, whether absolute or contingent, liquidated or unliquidated, whether due or not due, and however arising under or in connection with this Agreement, the
Notes and Drafts issued by such Guarantied Borrower and the other Loan Documents, including those arising under successive borrowing transactions under this Agreement which shall either continue the Obligations of Guarantied Borrower or from time to
time renew them after they have been satisfied; and 
 (b) those expenses set forth in Section 10.08. 

  
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 10.02 Liability of the Company Absolute. The Company agrees that its obligations under this Company
Guaranty are irrevocable, absolute, independent and unconditional and shall not be affected by any circumstance which constitutes a legal or equitable discharge of a guarantor or surety other than indefeasible payment in full of the Guarantied
Obligations. In furtherance of the foregoing and without limiting the generality thereof, the Company agrees as follows: 
 (a) This Company
Guaranty is a guaranty of payment when due and not of collectibility. 
 (b) The Administrative Agent may enforce this Company Guaranty upon
the occurrence of an Event of Default under this Agreement notwithstanding the existence of any dispute between Lenders and any Borrower with respect to the existence of such Event of Default. 

(c) The obligations of the Company under this Company Guaranty are independent of the obligations of each Guarantied Borrower under the Loan
Documents and the obligations of any other guarantor of the obligations of any Guarantied Borrower under the Loan Documents, and a separate action or actions may be brought and prosecuted against the Company whether or not any action is brought
against such Guarantied Borrower or any of such other guarantors and whether or not such Guarantied Borrower is joined in any such action or actions. 

(d) The Company’s payment of a portion, but not all, of the Guarantied Obligations shall in no way limit, affect, modify or abridge the
Company’s liability for any portion of the Guarantied Obligations that has not been paid. Without limiting the generality of the foregoing, if the Administrative Agent is awarded a judgment in any suit brought to enforce the Company’s
covenant to pay a portion of the Guarantied Obligations, such judgment shall not be deemed to release the Company from its covenant to pay the portion of the Guarantied Obligations that is not the subject of such suit. 

(e) Any Agent or any Lender, upon such terms as it deems appropriate, without notice or demand and without affecting the validity or
enforceability of this Company Guaranty or giving rise to any reduction, limitation, impairment, discharge or termination of the Company’s liability under this Company Guaranty, from time to time may (i) renew, extend, accelerate, increase
the rate of interest on, or otherwise change the time, place, manner or terms of payment of the Guarantied Obligations, (ii) settle, compromise, release or discharge, or accept or refuse any offer of performance with respect to, or
substitutions for, the Guarantied Obligations or any agreement relating thereto and/or subordinate the payment of the same to the payment of any other obligations; (iii) request and accept other guaranties of the Guarantied Obligations and take
and hold security for the payment of this Company Guaranty or the Guarantied Obligations; (iv) release, surrender, exchange, substitute, compromise, settle, rescind, waive, alter, subordinate or modify, with or without consideration, any
security for payment of the Guarantied Obligations, any other guaranties of the Guarantied Obligations, or any other obligation of any Person with respect to the Guarantied Obligations; (v) enforce and apply any security now or hereafter held
by or for the benefit of the Agents or any Lender in respect of this Company Guaranty or the Guarantied Obligations and direct the order or manner of sale thereof, or exercise any other right or remedy that the Agents or the Lenders, or any of them,
may have against any such security, as the Administrative Agent in its discretion may determine consistent 

  
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with this Agreement and any applicable security agreement, including foreclosure on any such security pursuant to one or more judicial or nonjudicial sales, whether or not every aspect of any
such sale is commercially reasonable, and even though such action operates to impair or extinguish any right of reimbursement or subrogation or other right or remedy of the Company against any Guarantied Borrower or any security for the Guarantied
Obligations; and (vi) exercise any other rights available to it under the Loan Documents. This Section 10.02(e) shall not modify Section 11.01. 

(f) This Company Guaranty and the obligations of the Company hereunder shall be valid and enforceable and shall not be subject to any
reduction, limitation, impairment, discharge or termination for any reason (other than indefeasible payment in full of the Guarantied Obligations), including the occurrence of any of the following, whether or not the Company shall have had notice or
knowledge of any of them: (i) any failure or omission to assert or enforce, or agreement or election not to assert or enforce, or the stay or enjoining, by order of court, by operation of law or otherwise, of the exercise or enforcement of, any
claim or demand or any right, power or remedy (whether arising under the Loan Documents, at law, in equity or otherwise) with respect to the Guarantied Obligations or any agreement relating thereto, or with respect to any other guaranty of or
security for the payment of the Guarantied Obligations; (ii) any rescission, waiver, amendment or modification of, or any consent to departure from, any of the terms or provisions (including provisions relating to Events of Default) of this
Agreement, any of the other Loan Documents or any agreement or instrument executed pursuant thereto, or of any other guaranty or security for the Guarantied Obligations, in each case whether or not in accordance with the terms of this Agreement or
such Loan Document or any agreement relating to such other guaranty or security; (iii) the Guarantied Obligations, or any agreement relating thereto, at any time being found to be illegal, invalid or unenforceable in any respect; (iv) the
application of payments received from any source (other than payments received pursuant to the other Loan Documents or from the proceeds of any security for the Guarantied Obligations, except to the extent such security also serves as collateral for
indebtedness other than the Guarantied Obligations) to the payment of indebtedness other than the Guarantied Obligations, even though the Agents or the Lenders, or any of them, might have elected to apply such payment to any part or all of the
Guarantied Obligations; (v) any Lender’s or Agent’s consent to the change, reorganization or termination of the corporate structure or existence of the Company or any of its Subsidiaries and to any corresponding restructuring of the
Guarantied Obligations; (vi) any failure to perfect or continue perfection of a security interest in any collateral which secures any of the Guarantied Obligations; (vii) any defenses, set-offs or counterclaims which any Guarantied
Borrower may allege or assert against any Agent or any Lender in respect of the Guarantied Obligations, including but not limited to failure of consideration, breach of warranty, payment, statute of frauds, statute of limitations, accord and
satisfaction and usury (but excluding the defense of payment in full of the Guaranteed Obligations); and (viii) any other act or thing or omission, or delay to do any other act or thing, which may or might in any manner or to any extent vary
the risk of the Company as an obligor in respect of the Guarantied Obligations. 
 10.03 Waivers by the Company. The Company hereby waives with
respect to the Guarantied Obligations, for the benefit of the Lenders and the Agents: 
 (a) any right to require any Agent or any Lender,
as a condition of payment or performance by the Company, to (i) proceed against any Guarantied Borrower, any other 

  
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guarantor of the Guarantied Obligations or any other Person, (ii) proceed against or exhaust any security held from such Guarantied Borrower, any other guarantor of the Guarantied
Obligations or any other Person, (iii) proceed against or have resort to any balance of any deposit account or credit on the books of any Agent or any Lender in favor of such Guarantied Borrower or any other Person, or (iv) pursue any
other remedy in the power of any Agent or any Lender whatsoever; 
 (b) any defense arising by reason of the incapacity, lack of authority
or any disability or other defense of any Guarantied Borrower including any defense based on or arising out of the lack of validity or the unenforceability of the Guarantied Obligations or any agreement or instrument relating thereto or by reason of
the cessation of the liability of such Guarantied Borrower from any cause other than indefeasible payment in full of the Guarantied Obligations; 

(c) any defense based upon any statute or rule of law which provides that the obligation of a surety must be neither larger in amount nor in
other respects more burdensome than that of the principal; 
 (d) any defense based upon any Agent’s or any Lender’s errors or
omissions in the administration of the Guarantied Obligations, except behavior which amounts to bad faith; 
 (e) (i) any principles or
provisions of law, statutory or otherwise, which are or might be in conflict with the terms of this Guaranty and any legal or equitable discharge of the Company’s obligations hereunder, (ii) the benefit of any statute of limitations
affecting the Company’s liability hereunder or the enforcement hereof, (iii) any rights to set-offs, recoupments and counterclaims, and (iv) promptness, diligence and any requirement that any Agent or any Lender protect, secure,
perfect or insure any security interest or lien or any property subject thereto; 
 (f) notices, demands, presentments, protests, notices of
protest, notices of dishonor and notices of any action or inaction, including acceptance of this Guaranty, notices of default under this Agreement or any agreement or instrument related thereto, notices of any renewal, extension or modification of
the Guarantied Obligations or any agreement related thereto, notices of any extension of credit to any Guarantied Borrower and notices of any of the matters referred to in Section 10.02 and any right to consent to any thereof; and 

(g) any defenses or benefits that may be derived from or afforded by law which limit the liability of or exonerate guarantors or sureties, or
which may conflict with the terms of this Company Guaranty. 
 10.04 Payment by the Company; Application of Payments. The Company hereby agrees, in
furtherance of the foregoing and not in limitation of any other right which the Administrative Agent or any other Person may have at law or in equity against the Company by virtue hereof, that upon the failure of any Guarantied Borrower to pay any
of the Guarantied Obligations when and as the same shall become due, whether at stated maturity, by required prepayment, declaration, acceleration, demand or otherwise (including amounts that would become due but for the operation of the automatic
stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C. § 362(a)), the Company will upon demand pay, or cause to be paid, in cash, to the Agent for the ratable benefit of the Lenders holding the Guarantied Obligations, an amount
equal to the sum of the unpaid principal amount of all Guarantied Obligations then due as 

  
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aforesaid, accrued and unpaid interest on such Guarantied Obligations (including interest which, but for the filing of a petition in bankruptcy with respect to such Guarantied Borrower, would
have accrued on such Guarantied Obligations, whether or not a claim is allowed against such Guarantied Borrower for such interest in any such bankruptcy proceeding) and all other Guarantied Obligations then owed to the Administrative Agent and/or
the Lenders as aforesaid. All such payments shall be applied promptly from time to time by the Administrative Agent: 
 First, to the
payment of the costs and expenses of any collection or other realization under this Company Guaranty, including reasonable compensation to the Administrative Agent and its agents and counsel, and all expenses, liabilities and advances made or
incurred by the Administrative Agent in connection therewith; 
 Second, to the payment of all other Guarantied Obligations to each
Lender holding Guarantied Obligations its applicable share as provided in this Agreement; and 
 Third, after payment in full of all
Guarantied Obligations, to the payment to the Company, or its successors or assigns, or to whosoever may be lawfully entitled to receive the same or as a court of competent jurisdiction may direct, of any surplus then remaining from such payments.

 10.05 Guarantor’s Rights of Subrogation, Contribution, Etc. Until the Guarantied Obligations shall have been indefeasibly paid in full and
the Commitments shall have terminated, the Company shall withhold exercise of (a) any claim, right or remedy, direct or indirect, the Company now has or may hereafter have against any Guarantied Borrower or any of its assets in connection with
this Company Guaranty or the performance by the Company of its obligations hereunder, in each case whether such claim, right or remedy arises in equity, under contract, by statute, under common law or otherwise and including (i) any right of
subrogation, reimbursement or indemnification that the Company now has or may hereafter have against such Guarantied Borrower, (ii) any right to enforce, or to participate in, any claim, right or remedy that any Agent or any Lender now has or
may hereafter have against such Guarantied Borrower, and (iii) any benefit of, and any right to participate in, any collateral or security now or hereafter held by any Agent or any Lender, and (b) any right of contribution the Company may
have against any other guarantor of the Guarantied Obligations. The Company further agrees that, to the extent the agreement to withhold the exercise of its rights of subrogation, reimbursement, indemnification and contribution as set forth herein
is found by a court of competent jurisdiction to be void or voidable for any reason, any rights of subrogation, reimbursement or indemnification the Company may have against any Guarantied Borrower or against any collateral or security, and any
rights of contribution the Company may have against any such other guarantor, shall be junior and subordinate to any rights any Agent or any Lender may have against such Guarantied Borrower, to all right, title and interest any Agent or any Lender
may have in any such collateral or security, and to any right any Agent or any Lender may have against such other guarantor. Each Agent, on behalf of Lenders, may use, sell or dispose of any item of collateral or security as it sees fit without
regard to any subrogation rights the Company may have, and upon any such disposition or sale any rights of subrogation against such collateral the Company may have shall terminate. If any amount shall be paid to the Company on account of any such
subrogation, reimbursement or indemnification rights at any time when all Guarantied Obligations shall not have been paid in full, such amount shall be held in trust for the Administrative Agent on behalf of the Lenders and shall forthwith be paid
over to the Administrative Agent for the benefit of the Lenders to be credited and applied against the Guarantied Obligations, whether matured or unmatured, in accordance with the terms hereof. 

10.06 Subordination of Other Obligations. Any indebtedness of any Guarantied Borrower now or hereafter held by the Company is hereby subordinated in
right of payment to the Guarantied Obligations, and any such indebtedness of such Guarantied Borrower to the Company collected or received by the 

  
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Company after an Event of Default has occurred and is continuing shall be held in trust for the Administrative Agent on behalf of the Lenders and shall forthwith be paid over to the
Administrative Agent for the benefit of the Lenders to be credited and applied against the Guarantied Obligations but without affecting, impairing or limiting in any manner the liability of the Company under any other provision of this Guaranty.

 10.07 [RESERVED]. 
 10.08 Expenses. The
Company agrees to pay, or cause to be paid, on demand, and to save the Administrative Agent and the Lenders harmless against liability for, any and all reasonable costs and expenses (including fees and disbursements of counsel and allocated costs of
internal counsel) incurred or expended by the Administrative Agent or any Lender in connection with the enforcement of or preservation of any rights under this Company Guaranty. 

10.09 Continuing Guaranty; Termination of Guaranty. This Company Guaranty is a continuing guaranty and shall remain in effect until all of the
Guarantied Obligations shall have been indefeasibly paid in full and the Commitments shall have terminated. The Company hereby irrevocably waives any right to revoke this Company Guaranty as to future transactions giving rise to any Guarantied
Obligations. 
 10.10 Authority of the Company or any Guarantied Borrower. It is not necessary for any Lender or any Agent to inquire into the
capacity or powers of any Guarantied Borrower or the officers, directors or any agents acting or purporting to act on behalf of any Guarantied Borrower. 

10.11 Financial Condition of Guarantied Borrowers. Any extensions of credit may be granted to any Guarantied Borrower or continued from time to time
without notice to or authorization from the Company regardless of the financial or other condition of such Guarantied Borrower at the time of any such grant or continuation. No Lender or Agent shall have any obligation to disclose or discuss with
the Company their assessment, or the Company’s assessment, of the financial condition of such Guarantied Borrower. The Company has adequate means to obtain information from each Guarantied Borrower on a continuing basis concerning the financial
condition of such Guarantied Borrower and its ability to perform its obligations under the Loan Documents, and the Company assumes the responsibility for being and keeping informed of the financial condition of such Guarantied Borrower and of all
circumstances bearing upon the risk of nonpayment of the Guarantied Obligations. The Company hereby waives and relinquishes any duty on the part of any Agent or any Lender to disclose any matter, fact or thing relating to the business, operations or
conditions of each Guarantied Borrower now known or hereafter known by any Agent or any Lender. 
 10.12 Rights Cumulative. The rights, powers and
remedies given to the Lenders and the Agents by this Company Guaranty are cumulative and shall be in addition to and independent of all rights, powers and remedies given to any Lender and any Agent by virtue of any statute or rule of law or in any
of the other Loan Documents or any agreement between the Company and any Lender and/or any Agent or between any Guarantied Borrower and any Lender and/or any Agent. Any forbearance or failure to exercise, and any delay by any Lender or any Agent in
exercising, any right, power or remedy hereunder shall not impair any such right, power or remedy or be construed to be a waiver thereof, nor shall it preclude the further exercise of any such right, power or remedy. 

10.13 Bankruptcy; Post-Petition Interest; Reinstatement of Guaranty. (a) So long as any Guarantied Obligations remain outstanding, the Company
shall not, without the prior written consent of the Administrative Agent in accordance with the terms of this Agreement, commence or join with any 

  
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other Person in commencing any bankruptcy, reorganization or insolvency proceedings of or against any Guarantied Borrower. The obligations of the Company under this Company Guaranty shall not be
reduced, limited, impaired, discharged, deferred, suspended or terminated by any proceeding, voluntary or involuntary, involving the bankruptcy, insolvency, receivership, reorganization, liquidation or arrangement of any Guarantied Borrower or by
any defense which such Guarantied Borrower may have by reason of the order, decree or decision of any court or administrative body resulting from any such proceeding. 

(b) The Company acknowledges and agrees that any interest on any portion of the Guarantied Obligations which accrues after the commencement of
any proceeding referred to in clause (a) above (or, if interest on any portion of the Guarantied Obligations ceases to accrue by operation of law by reason of the commencement of said proceeding, such interest as would have accrued on such
portion of the Guarantied Obligations if said proceedings had not been commenced) shall be included in the Guarantied Obligations because it is the intention of the Company and the Administrative Agent that the Guarantied Obligations which are
guarantied by the Company pursuant to this Guaranty should be determined without regard to any rule of law or order which may relieve any Guarantied Borrower of any portion of such Guarantied Obligations. The Company will permit any trustee in
bankruptcy, receiver, debtor in possession, assignee for the benefit of creditors or similar person to pay the Administrative Agent, or allow the claim of the Administrative Agent in respect of, any such interest accruing after the date on which
such proceeding is commenced. 
 (c) In the event that all or any portion of the Guarantied Obligations are paid by any Guarantied Borrower,
the obligations of the Company hereunder shall continue and remain in full force and effect or be reinstated, as the case may be, in the event that all or any part of such payment(s) are rescinded or recovered directly or indirectly from any Agent
or any Lender as a preference, fraudulent transfer or otherwise, and any such payments which are so rescinded or recovered shall constitute Guarantied Obligations for all purposes under this Company Guaranty. 

ARTICLE XI 

MISCELLANEOUS 
 11.01 Amendments,
Etc. No amendment or waiver of any provision of this Agreement or any other Loan Document, and no consent to any departure by the Company or any other Loan Party therefrom, shall be effective unless in writing signed by the Required Lenders and
the Company or the applicable Loan Party, as the case may be, and acknowledged by the Administrative Agent, and each such waiver or consent shall be effective only in the specific instance and for the specific purpose for which given; provided,
however, that no such amendment, waiver or consent shall: 
 (a) waive any condition set forth in Section 4.01(a) (other
than any condition pursuant to Section 4.01(a)(viii)) without the written consent of each Lender; 
 (b) extend or increase the
Commitment of any Lender (or reinstate any Commitment terminated pursuant to Section 8.02) or increase or extend the obligation of any Lender to accept Drafts except as permitted by Section 2.15, in each case without the
written consent of such Lender; 

  
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 (c) postpone any date fixed by this Agreement or any other Loan Document for any payment of
principal, interest, fees or other amounts due to the Lenders (or any of them) hereunder (including a decrease in any amount payable in respect of the Bankers’ Acceptance Facility) or under any other Loan Document without the written consent of
each Lender directly affected thereby; 
 (d) reduce the principal of, or the rate of interest specified herein on, any Loan or L/C
Borrowing, or (subject to clause (v) of the second proviso to this Section 11.01) any fees or other amounts payable hereunder or under any other Loan Document without the written consent of each Lender directly affected thereby;
provided, however, that only the consent of the Required Lenders shall be necessary to amend the definition of “Default Rate” or to waive any obligation of the Borrowers to pay interest at the Default Rate; 

(e) change Section 2.13 or Section 8.03 in a manner that would alter the pro rata sharing of payments required thereby
or amend the definition of “Pro Rata Share”, without the written consent of each Lender; 
 (f) change any provision of this
Section 11.01 or the definition of “Required Lenders” or any other provision hereof specifying the number or percentage of Lenders required to amend, waive or otherwise modify any rights hereunder or make any determination or
grant any consent hereunder, without the written consent of each Lender; or 
 (g) release the Company from the Company Guaranty without the
written consent of each Lender; 
 and, provided further, that (i) no amendment, waiver or consent shall, unless in writing and
signed by the L/C Issuer in addition to the Lenders required above, affect the rights or duties of the L/C Issuer under this Agreement or any Issuer Document relating to any Letter of Credit issued or to be issued by it; (ii) no amendment,
waiver or consent shall, unless in writing and signed by the Canadian Administrative Agent in addition to the Lenders required above, affect the rights or duties of the Canadian Administrative Agent under this Agreement; (iii) no amendment,
waiver or consent shall, unless in writing and signed by the Administrative Agent in addition to the Lenders required above, affect the rights or duties of the Administrative Agent under this Agreement or any other Loan Document;
(iv) Section 11.06(h) may not be amended, waived or otherwise modified without the consent of each Granting Lender all or any part of whose Loans are being funded by an SPC at the time of such amendment, waiver or other modification; and
(v) the Fee Letter may be amended, or rights or privileges thereunder waived, only in a writing executed by the parties thereto. Notwithstanding anything to the contrary herein, no Defaulting Lender shall have any right to approve or disapprove
any amendment, waiver or consent hereunder, except that the Commitment of such Lender may not be increased or extended without the consent of such Lender. 

  
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 11.02 Notices and Other Communications; Facsimile Copies. 

(a) General. Except in the case of notices and other communications expressly permitted to be given by telephone (and except as
provided in subsection (b) below), all notices and other communications provided for hereunder shall be in writing and shall be delivered by hand or overnight courier service, mailed by certified or registered mail or sent by telecopier
as follows, and all notices and other communications expressly permitted hereunder to be given by telephone shall be made to the applicable telephone number, as follows: 

(i) if to any Borrower, the Administrative Agent, the L/C Issuer or the Canadian Administrative Agent, to the address, facsimile number,
electronic mail address or telephone number specified for such Person on Schedule 11.02; and 
 (ii) if to any other Lender, to the
address, facsimile number, electronic mail address or telephone number specified in its Administrative Questionnaire. 
 Notices sent by
hand or overnight courier service, or mailed by certified or registered mail, shall be deemed to have been given when received; notices sent by telecopier shall be deemed to have been given when sent (except that, if not given during normal business
hours for the recipient, shall be deemed to have been given at the opening of business on the next business day for the recipient). Notices delivered through electronic communications to the extent provided in subsection (b) below, shall
be effective as provided in such subsection (b). 
 (b) Electronic Communications. All notices hereunder to any Borrower shall
be in writing and shall be delivered by hand or overnight courier service, mailed by certified or registered mail or sent by telecopier (or, to the extent permitted hereunder to be given by telephone, immediately confirmed in a writing so delivered,
mailed or sent). Notices and other communications to the Lenders and the L/C Issuer hereunder may be delivered or furnished by electronic communication (including e-mail and Internet or intranet websites) pursuant to procedures approved by the
Administrative Agent, provided that the foregoing shall not apply to notices to any Lender or the L/C Issuer pursuant to Article II if such Lender or the L/C Issuer, as applicable, has notified the Administrative Agent that it is
incapable of receiving notices under such Article by electronic communication. The Administrative Agent or the Company may, in its discretion, agree to accept notices and other communications to it hereunder by electronic communications pursuant to
procedures approved by it, provided that approval of such procedures may be limited to particular notices or communications. 

Unless the Administrative Agent otherwise prescribes, (i) notices and other communications sent to an e-mail address shall be deemed
received upon the sender’s receipt of an acknowledgement from the intended recipient (such as by the “return receipt requested” function, as available, return e-mail or other written acknowledgement), provided that if such
notice or other communication is not sent during the normal business hours of the recipient, such notice or communication shall be deemed to have been sent at the opening of business on the next business day for the recipient, and (ii) notices
or communications posted to an Internet or intranet website shall be deemed received upon the deemed receipt by the intended recipient at its e-mail address as described in the foregoing clause (i) of notification that such notice or
communication is available and identifying the website address therefor. 
 (c) The Platform. THE PLATFORM IS PROVIDED “AS
IS” AND “AS AVAILABLE.” THE AGENT PARTIES (AS DEFINED BELOW) DO NOT WARRANT THE ACCURACY OR COMPLETENESS OF THE BORROWER MATERIALS OR THE ADEQUACY OF THE PLATFORM, AND EXPRESSLY DISCLAIM LIABILITY FOR ERRORS IN OR OMISSIONS FROM THE
BORROWER MATERIALS. NO WARRANTY OF ANY KIND, EXPRESS, IMPLIED OR STATUTORY, INCLUDING ANY WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT OF THIRD PARTY RIGHTS OR FREEDOM FROM VIRUSES OR OTHER CODE DEFECTS, IS MADE BY
ANY AGENT PARTY IN CONNECTION WITH THE BORROWER MATERIALS OR THE PLATFORM. In no event shall the Administrative 

  
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Agent or any of its Related Parties (collectively, the “Agent Parties”) have any liability to the Borrower, any Lender or any other Person for losses, claims, damages,
liabilities or expenses of any kind (whether in tort, contract or otherwise) arising out of the Borrower’s or the Administrative Agent’s transmission of Borrower Materials through the internet, except to the extent that such losses,
claims, damages, liabilities or expenses are determined by a court of competent jurisdiction by a final and nonappealable judgment to have resulted from the gross negligence or willful misconduct of such Agent Party; provided, however, that
in no event shall any Agent Party have any liability to the Borrower, any Lender or any other Person for indirect, special, incidental, consequential or punitive damages (as opposed to direct or actual damages). 

(d) Change of Address, Etc. Each Borrower, the Administrative Agent, the Canadian Administrative Agent and the L/C Issuer may change
its address, facsimile number, electronic mail address or telephone number for notices and other communications hereunder by notice to the other parties hereto. Each other Lender may change its address, facsimile number, electronic mail address or
telephone number for notices and other communications hereunder by notice to the Borrowers, the Administrative Agent, the Canadian Administrative Agent and the L/C Issuer. Furthermore, each Public Lender (as defined in Section 6.02)
agrees to cause at least one individual at or on behalf of such Public Lender to at all times have selected the “Private Side Information” or similar designation on the content declaration screen of the Platform (as defined in
Section 6.02) in order to enable such Public Lender or its delegate, in accordance with such Public Lender’s compliance procedures and applicable Law, including United States Federal and state securities Laws, to make reference to
Borrower Materials (as defined in Section 1.01) that are not made available through the “Public Side Information” portion of the Platform and that may contain material non-public information with respect to the Borrower or its
securities for purposes of United States Federal or state securities laws. 
 (e) Reliance by Agents and Lenders. Each Agent and
Lender shall be entitled to rely and act upon any notices (including telephonic Committed Loan Notices and Drawing Notices) purportedly given by or on behalf of any Borrower, which such Agent or Lender believes in good faith to have been given by a
duly authorized officer or other person authorized to borrow on behalf of the Applicable Borrower, even if (i) such notices were not made in a manner specified herein, were incomplete or were not preceded or followed by any other form of notice
specified herein, or (ii) the terms thereof, as understood by the recipient, varied from any confirmation thereof. Each Borrower shall indemnify each Agent, the L/C Issuer, each Lender and the Related Parties of each of them from all losses,
costs, expenses and liabilities resulting from the reliance by such Person on each notice purportedly given by or on behalf of such Borrower. All telephonic notices to and other communications with an Agent may be recorded by such Agent, and each of
the parties hereto hereby consents to such recording. 
 11.03 No Waiver; Cumulative Remedies; Enforcement. No failure by any Lender or the Agents to
exercise, and no delay by any such Person in exercising, any right, remedy, power or privilege hereunder shall operate as a waiver thereof; nor shall any single or partial exercise of any right, remedy, power or privilege hereunder preclude any
other or further exercise thereof or the exercise of any other right, remedy, power or privilege. The rights, remedies, powers and privileges herein provided are cumulative and not exclusive of any rights, remedies, powers and privileges provided by
law. 
 Notwithstanding anything to the contrary contained herein or in any other Loan Document, the authority to enforce rights and
remedies hereunder and under the other Loan Documents against the Loan 

  
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Parties or any of them shall be vested exclusively in, and all actions and proceedings at law in connection with such enforcement shall be instituted and maintained exclusively by, the
Administrative Agent in accordance with Section 8.02 for the benefit of all the Lenders and the L/C Issuer; provided, however, that the foregoing shall not prohibit (a) the Administrative Agent from exercising on its
own behalf the rights and remedies that inure to its benefit (solely in its capacity as Administrative Agent) hereunder and under the other Loan Documents, (b) the L/C Issuer from exercising the rights and remedies that inure to its benefit
(solely in its capacity as L/C Issuer) hereunder and under the other Loan Documents, (c) any Lender from exercising setoff rights in accordance with Section 11.08, or (d) any Lender from filing proofs of claim or appearing and
filing pleadings on its own behalf during the pendency of a proceeding relative to any Loan Party under any Debtor Relief Law; and provided, further, that if at any time there is no Person acting as Administrative Agent hereunder and
under the other Loan Documents, then (i) the Required Lenders shall have the rights otherwise ascribed to the Administrative Agent pursuant to Section 8.02 and (ii) in addition to the matters set forth in clauses (b),
(c) and (d) of the preceding proviso, any Lender may, with the consent of the Required Lenders, enforce any rights and remedies available to it and as authorized by the Required Lenders. 

11.04 Expenses; Indemnity; Damage Waiver. 

(a) Costs and Expenses. The Borrowers agree, jointly and severally, (i) to pay or reimburse the Agents for all costs and expenses
incurred in connection with the syndication of the credit facilities provided for herein, the development, preparation, negotiation and execution of this Agreement and the other Loan Documents and any amendment, waiver, consent or other modification
of the provisions hereof and thereof (whether or not the transactions contemplated hereby or thereby are consummated), and the consummation and administration of the transactions contemplated hereby and thereby, including all Attorney Costs,
(ii) to pay the L/C Issuer all fees, costs and charges required under Section 2.03(j) and (iii) to pay or reimburse the Agents, the L/C Issuer and each Lender for all costs and expenses incurred in connection with the
enforcement, attempted enforcement, or preservation of any rights or remedies under this Agreement or the other Loan Documents (including all such costs and expenses incurred during any “workout” or restructuring in respect of the
Obligations and during any legal proceeding, including any proceeding under any Debtor Relief Law), including all Attorney Costs. The foregoing costs and expenses shall include all search, filing, recording, title insurance and appraisal charges and
fees and taxes related thereto, and other out-of-pocket expenses incurred by the Agents and the cost of independent public accountants and other outside experts retained by the Agents or any Lender. All amounts due under this
Section 11.04 shall be payable within 20 Business Days after demand therefor. 
 (b) Indemnification by the Borrowers.
Whether or not the transactions contemplated hereby are consummated, the Borrowers shall jointly and severally indemnify and hold harmless each Agent (and any sub-agent thereof), the L/C Issuer, the Arranger, each Lender and each Related Party of
any of the foregoing Persons (each such Person being called an “Indemnitee”) from and against any and all liabilities, obligations, losses, damages, penalties, claims, demands, actions, judgments, suits, costs, expenses and
disbursements (including Attorney Costs) of any kind or nature whatsoever which may at any time be imposed on, incurred by or asserted against any such Indemnitee in any way relating to or arising out of or in connection with (i) the execution,
delivery, enforcement, performance or administration of any Loan Document or any other agreement, letter or instrument delivered in connection with the transactions contemplated thereby or the consummation of the transactions contemplated thereby,
(ii) any Commitment, 

  
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Loan or Letter of Credit or the use or proposed use of the proceeds therefrom (including any refusal by the L/C Issuer to honor a demand for payment under a Letter of Credit if the documents
presented in connection with such demand do not strictly comply with the terms of such Letter of Credit), or related to any Canadian Dollar transactions, (iii) any actual or alleged presence or release of Hazardous Materials on or from any
property owned or operated by the Borrower or any of its Subsidiaries, or any Environmental Liability related in any way to the Borrower or any of its Subsidiaries or (iv) any actual or prospective claim, litigation, investigation or proceeding
relating to any of the foregoing, whether based on contract, tort or any other theory (including any investigation of, preparation for, or defense of any pending or threatened claim, investigation, litigation or proceeding) and regardless of whether
any Indemnitee is a party thereto (all the foregoing, collectively, the “Indemnified Liabilities”); provided that such indemnity shall not, as to any Indemnitee, be available to the extent that such liabilities, obligations,
losses, damages, penalties, claims, demands, actions, judgments, suits, costs, expenses or disbursements (A) are determined by a court of competent jurisdiction by final and nonappealable judgment to have resulted from the gross negligence or
willful misconduct of such Indemnitee or (B) result from non-tort claims by a Borrower against such Indemnitee that are successful on the merits as determined by a court of competent jurisdiction by final and nonappealable judgment. 

(c) Reimbursement by Lenders. To the extent that the Borrowers for any reason fail to indefeasibly pay any amount required under
subsection (a) or (b) of this Section to be paid by it to the Agents (or any sub-agent thereof), the L/C Issuer, the Arranger or any Related Party of any of the foregoing (it being acknowledged that, for the avoidance of doubt, such
required amounts do not include any fees arising solely from the Fee Letter), each Lender severally agrees to pay to the Agents (or any such sub-agent), the L/C Issuer, the Arranger or such Related Party, as the case may be, such Lender’s Pro
Rata Share (determined as of the time that the applicable unreimbursed expense or indemnity payment is sought) of such unpaid amount, provided that the unreimbursed expense or indemnified loss, claim, damage, liability or related expense, as
the case may be, was incurred by or asserted against the Agents (or any such sub-agent) or the L/C Issuer in its capacity as such, or against any Related Party of any of the foregoing acting for an Agent (or any such sub-agent) or L/C Issuer in
connection with such capacity. The obligations of the Lenders under this subsection (b) are subject to the provisions of Section 2.12(d). 

(d) Waiver of Consequential Damages, Etc. To the fullest extent permitted by applicable law, no Borrower shall assert, and each
Borrower hereby waives, any claim against any Indemnitee, on any theory of liability, for special, indirect, consequential or punitive damages (as opposed to direct or actual damages) arising out of, in connection with, or as a result of, this
Agreement, any other Loan Document or any agreement or instrument contemplated hereby, the transactions contemplated hereby or thereby, any Loan or Letter of Credit or the use of the proceeds thereof. No Indemnitee referred to in subsection
(b) above shall be liable for any damages arising from the use by unintended recipients of any information or other materials distributed by it through telecommunications, electronic or other information transmission systems in connection
with this Agreement or the other Loan Documents or the transactions contemplated hereby or thereby. 
 (e) Payments. All amounts due
under this Section shall be payable not later than 20 Business Days after demand therefor. 

  
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 (f) The agreements in this Section 11.04 shall survive the resignation of the
Administrative Agent, the Canadian Administrative Agent, the L/C Issuer or the Arranger, the replacement of any Lender, the termination of the Aggregate Commitments and the repayment, satisfaction or discharge of all the other Obligations. 

11.05 Payments Set Aside. To the extent that any payment by or on behalf of a Borrower is made to either Agent or any Lender, or either Agent or any
Lender exercises its right of set-off, and such payment or the proceeds of such set-off or any part thereof is subsequently invalidated, declared to be fraudulent or preferential, set aside or required (including pursuant to any settlement entered
into by an Agent or such Lender in its discretion) to be repaid to a trustee, receiver or any other party, in connection with any proceeding under any Debtor Relief Law or otherwise, then (a) to the extent of such recovery, the obligation or
part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such set-off had not occurred, and (b) each Lender severally agrees to pay to the Applicable Agent
upon demand its applicable share of any amount so recovered from or repaid by such Agent, plus interest thereon from the date of such demand to the date such payment is made at a rate per annum equal to (A) in the case of Domestic Loans and L/C
Credit Extensions, the Federal Funds Rate from time to time in effect and (B) in the case of Canadian Loans and Bankers’ Acceptance Credit Extensions, the Overnight Canadian Rate from time to time in effect. 

11.06 Successors and Assigns. 
 (a) The
provisions of this Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns permitted hereby, except that the Borrowers may not assign or otherwise transfer any of their rights or
obligations hereunder (except in a transaction permitted under Section 7.02) without the prior written consent of each Agent and each Lender and no Lender may assign or otherwise transfer any of its rights or obligations hereunder except
(i) to an Eligible Assignee in accordance with the provisions of Section 11.06(b), (ii) by way of participation in accordance with the provisions of Section 11.06(d), (iii) by way of pledge or assignment of a
security interest subject to the restrictions of Sections 11.06(f) and (i), or (iv) to an SPC in accordance with the provisions of Section 11.06(h) (and any other attempted assignment or transfer by any party hereto
shall be null and void). Nothing in this Agreement, expressed or implied, shall be construed to confer upon any Person (other than the parties hereto, their respective successors and assigns permitted hereby, Participants to the extent provided in
Section 11.06(d) and, to the extent expressly contemplated hereby, the Indemnitees) any legal or equitable right, remedy or claim under or by reason of this Agreement. 

(b) Any Lender may at any time assign to one or more Eligible Assignees all or a portion of its rights and obligations under this Agreement
(including all or a portion of its Commitment and the Loans (including for purposes of this Section 11.06(b), participations in L/C Obligations) at the time owing to it); provided that (i) except in the case of an assignment
of the entire remaining amount of the assigning Lender’s Commitment and the Loans at the time owing to it or in the case of an assignment to a Lender or an Affiliate of a Lender or an Approved Fund with respect to a Lender, the aggregate amount
of the Commitment (which for this purpose includes Loans outstanding thereunder) subject to each such assignment, determined as of the date the Assignment and Assumption with respect to such assignment is delivered to the Administrative Agent or, if
“Trade Date” is specified in the Assignment and Assumption, as of the Trade Date, shall not be less than $5,000,000 unless each of the Administrative Agent and, so 

  
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long as no Event of Default has occurred and is continuing, the Company otherwise consents (each such consent not to be unreasonably withheld or delayed); (ii) each partial assignment shall
be made as an assignment of a proportionate part of all the assigning Lender’s rights and obligations under this Agreement with respect to the Loans or the Commitment assigned, (iii) any assignment of a Commitment must be approved by the
Administrative Agent (such approval not to be unreasonably withheld or delayed) unless the Person that is the proposed assignee is itself a Lender or an Affiliate of a Lender or an Approved Fund (whether or not the proposed assignee would otherwise
qualify as an Eligible Assignee); (iv) any assignment of a Commitment that increases the obligation of the assignee to participate in exposure under one or more Letters of Credit (whether or not then outstanding) must be approved by the L/C
Issuer (such approval not to be unreasonably withheld or delayed); and (v) the parties to each assignment shall execute and deliver to the Administrative Agent an Assignment and Assumption and (except in the case of an assignment by a Lender to
its Affiliate) a processing and recordation fee of $3,500, provided, however, that the Administrative Agent may in its sole discretion elect to waive such processing and recordation fee in the case of any assignment, and the Eligible Assignee, if it
shall not be a Lender, shall deliver to the Administrative Agent an Administrative Questionnaire. Subject to acceptance and recording thereof by the Administrative Agent pursuant to Section 11.06(c), from and after the effective date
specified in each Assignment and Assumption, the Eligible Assignee thereunder shall be a party to this Agreement and, to the extent of the interest assigned by such Assignment and Assumption, have the rights and obligations of a Lender under this
Agreement, and the assigning Lender thereunder shall, to the extent of the interest assigned by such Assignment and Assumption, be released from its obligations under this Agreement (and, in the case of an Assignment and Assumption covering all of
the assigning Lender’s rights and obligations under this Agreement, such Lender shall cease to be a party hereto but shall continue to be entitled to the benefits of Sections 3.01, 3.04, 3.05 and 11.04 with respect
to facts and circumstances occurring prior to the effective date of such assignment). Upon request, each Borrower (at its expense) shall execute and deliver a Note to the assignee Lender. Any assignment or transfer by a Lender of rights or
obligations under this Agreement that does not comply with this Section 11.06(b) shall be treated for purposes of this Agreement as a sale by such Lender of a participation in such rights and obligations in accordance with
Section 11.06(d). 
 (c) The Administrative Agent, acting solely for this purpose as an agent of the Borrowers, shall maintain
at the Administrative Agent’s Office a copy of each Assignment and Assumption delivered to it and a register for the recordation of the names and addresses of the Lenders, and the Commitments of, and principal amounts of the Loans and L/C
Obligations owing to, each Lender pursuant to the terms hereof from time to time (the “Register”). The entries in the Register shall be conclusive absent manifest error, and the Borrowers, the Administrative Agent and the Lenders
may treat each Person whose name is recorded in the Register pursuant to the terms hereof as a Lender hereunder for all purposes of this Agreement, notwithstanding notice to the contrary. The Register shall be available for inspection by the
Company, at any reasonable time and from time to time upon reasonable prior notice. In addition, at any time that a request for a consent for a material or substantive change to the Loan Documents is pending, any Lender wishing to consult with other
Lenders in connection therewith may request and receive from the Administrative Agent a copy of the Register. 

  
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 (d)(i) In addition to sales of Canadian Participations by Canadian Lenders pursuant to
Section 2.01(b)(ii), any Lender may at any time, without the consent of, or notice to, the Administrative Agent, sell participations to any Person (other than a natural person, any Borrower, any of the Borrowers’ Affiliates or
Subsidiaries and any Defaulting Lender) (each, a “Participant”) in all or a portion of such Lender’s rights and/or obligations under this Agreement (including all or a portion of its Commitment and/or the Loans (including such
Lender’s participations in L/C Obligations) owing to it); provided that (i) unless a Default or Event of Default has occurred and is continuing, the Company shall have approved the sale of participations to such Person (such
approval not to be unreasonably withheld or delayed); (ii) no participations in Canadian Loans or Bankers’ Acceptances shall be sold to any Person that is not a Canadian Resident; (iii) such Lender’s obligations under this
Agreement shall remain unchanged; (iv) such Lender shall remain solely responsible to the other parties hereto for the performance of such obligations; (v) the Borrowers, the Agents, the L/C Issuer and the other Lenders shall continue to
deal solely and directly with such Lender in connection with such Lender’s rights and obligations under this Agreement; and (vi) such Lender complies with Section 11.06(d)(ii); provided further that clauses
(i) through (v) of the foregoing proviso are not applicable to Canadian Participations. Any agreement or instrument pursuant to which a Lender sells such a participation shall provide that such Lender shall retain the sole right to enforce
this Agreement and to approve any amendment, modification or waiver of any provision of this Agreement; provided that such agreement or instrument may provide that such Lender will not, without the consent of the Participant, agree to any
amendment, waiver or other modification described in the first proviso to Section 11.01 that directly affects such Participant. Subject to Section 11.06(e), the Borrowers agree that each Participant shall be entitled to the
benefits of Sections 3.01, 3.04 and 3.05 to the same extent as if it were a Lender and had acquired its interest by assignment pursuant to Section 11.06(b). To the extent permitted by law, each Participant also shall
be entitled to the benefits of Section 11.08 as though it were a Lender, provided such Participant agrees to be subject to Section 2.13 as though it were a Lender. 

(ii) Each Lender that sells a participation shall, acting solely for this purpose as an agent of the Applicable Borrower,
maintain a register on which it enters the name and address of each Participant and the principal amounts (and stated interest) of each Participant’s interest in the Loans or other obligations under this Agreement (the “Participant
Register”); provided that no Lender shall have any obligation to disclose all or any portion of the Participant Register to any Person (including the identity of any Participant or any information relating to a Participant’s interest
in any Commitments, Loans, Letters of Credit or its other obligations under any Loan Document) except to the extent that such disclosure is necessary to establish that such Commitment, Loan, Letter of Credit or other obligation is in registered form
under Section 5f.103-1(c) of the U.S. Treasury Regulations. The entries in the Participant Register shall be conclusive absent manifest error, and such Lender may treat each person whose name is recorded in the Participant Register as the
owner of such participation for all purposes of this Agreement notwithstanding any notice to the contrary. 
 (e) A Participant shall not be
entitled to receive any greater payment under Section 3.01 or 3.04 than the applicable Lender would have been entitled to receive with respect to the participation sold to such Participant, unless the sale of the participation to
such Participant is made with the Company’s prior written consent. Notwithstanding anything to the contrary in Section 11.14(a)(iii)(A), a Participant that would be a Foreign Lender if it were a Lender shall be entitled to the
benefits of Section 3.01 as if it were a Lender if the Company is notified of the participation sold to such Participant and such Participant agrees, for the benefit of the Company, to comply with Section 11.14 as though it
were a Lender. 

  
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 (f) Any Lender may at any time pledge or assign a security interest in all or any portion of its
rights under this Agreement (including under its Note, if any) to secure obligations of such Lender, including any pledge or assignment to secure obligations to a Federal Reserve Bank; provided that no such pledge or assignment shall release
such Lender from any of its obligations hereunder or substitute any such pledgee or assignee for such Lender as a party hereto. 
 (g) As
used herein, the following terms have the following meanings: 
 “Eligible Assignee” means (a) a Lender; (b) an
Affiliate of a Lender; (c) an Approved Fund; and (d) any other Person (other than a natural person) approved by (i) the Administrative Agent, and (ii) unless a Default or an Event of Default has occurred and is continuing, the
Company (each such approval not to be unreasonably withheld or delayed); provided that notwithstanding the foregoing, (i) “Eligible Assignee” shall not include any Borrower, any of the Borrowers’ Affiliates or
Subsidiaries, or any Defaulting Lender and (ii) in the case of clauses (a), (b) and (c), no such Lender, Affiliate or Approved Fund shall be an Eligible Assignee for purposes of Canadian Loans or Bankers’ Acceptances unless such
Person is a Canadian Resident. 
 (h) Notwithstanding anything to the contrary contained herein, any Lender (a “Granting
Lender”) may grant to a special purpose funding vehicle identified as such in writing from time to time by the Granting Lender to the Administrative Agent and the Company (an “SPC”) the option to provide all or any part of
any Committed Loan that such Granting Lender would otherwise be obligated to make pursuant to this Agreement; provided that (i) nothing herein shall constitute a commitment by any SPC to fund any Committed Loan, and (ii) if an SPC
elects not to exercise such option or otherwise fails to make all or any part of such Committed Loan, the Granting Lender shall be obligated to make such Committed Loan pursuant to the terms hereof or, if it fails to do so, to make such payment to
the Applicable Agent as is required under Section 2.12(b)(ii); provided further that no such grant to an SPC shall impose Taxes or Other Taxes on any Borrower. Each party hereto hereby agrees that (i) neither the grant to any
SPC nor the exercise by any SPC of such option shall increase the costs or expenses or otherwise increase or change the obligations of the Company under this Agreement (including its obligations under Section 3.04), (ii) no SPC
shall be liable for any indemnity or similar payment obligation under this Agreement for which a Lender would be liable, and (iii) the Granting Lender shall for all purposes, including the approval of any amendment, waiver or other modification
of any provision of any Loan Document, remain the lender of record hereunder. The making of a Committed Loan by an SPC hereunder shall utilize the Commitment of the Granting Lender to the same extent, and as if, such Committed Loan were made by such
Granting Lender. In furtherance of the foregoing, each party hereto hereby agrees (which agreement shall survive the termination of this Agreement) that, prior to the date that is one year and one day after the payment in full of all outstanding
commercial paper or other senior debt of any SPC, it will not institute against, or join any other Person in instituting against, such SPC any bankruptcy, reorganization, arrangement, insolvency, or liquidation proceeding under the laws of the
United States or any State thereof. Notwithstanding anything to the contrary contained herein, any SPC may (i) with notice to, but without prior consent of the Company and the Administrative Agent and without paying any processing fee therefor,
assign all or any portion 

  
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of its right to receive payment with respect to any Committed Loan to the Granting Lender and (ii) disclose on a confidential basis any non-public information relating to its funding of
Committed Loans to any rating agency, commercial paper dealer or provider of any surety or Guarantee or credit or liquidity enhancement to such SPC. 

(i) Notwithstanding anything to the contrary contained herein, any Lender that is a Fund may create a security interest in all or any portion
of the Loans owing to it and the Note, if any, held by it to the trustee for holders of obligations owed, or securities issued, by such Fund as security for such obligations or securities, provided that unless and until such trustee actually
becomes a Lender in compliance with the other provisions of this Section 11.06, (a) no such pledge shall release the pledging Lender from any of its obligations under the Loan Documents and (b) such trustee shall not be
entitled to exercise any of the rights of a Lender under the Loan Documents even though such trustee may have acquired ownership rights with respect to the pledged interest through foreclosure or otherwise. For purposes of this
Section 11.06(i), “Fund” means any Person (other than a natural person) that is (or will be) engaged in making, purchasing, holding or otherwise investing in commercial loans and similar extensions of credit in the
ordinary course of its business. 
 (j) Notwithstanding anything to the contrary contained herein, if at any time Wells Fargo Bank, National
Association assigns all of its Commitment and Loans pursuant to Section 11.06(b), Wells Fargo Bank, National Association may, upon 30 days’ notice to the Company and the Lenders, resign as L/C Issuer. In the event of any such
resignation as L/C Issuer, the Company shall be entitled to appoint from among the Lenders a successor L/C Issuer hereunder; provided, however, that no failure by the Company to appoint any such successor shall affect the resignation of Wells
Fargo Bank, National Association as L/C Issuer. In the event that each Lender selected by the Company as L/C Issuer declines the appointment, Bank of America shall become the L/C Issuer, without further action by the Company or the Lenders. If Wells
Fargo Bank, National Association resigns as L/C Issuer, it shall retain all the rights and obligations of the L/C Issuer hereunder with respect to all Letters of Credit outstanding as of the effective date of its resignation as L/C Issuer and all
L/C Obligations with respect thereto (including the right to require the Lenders to make Base Rate Committed Loans or fund risk participations in Unreimbursed Amounts pursuant to Section 2.03(c)). 

(k) Electronic Execution of Assignments. The words “execution,” “signed”, “signature,” and words of like
import in any Assignment and Assumption shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature or
the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and
Records Act, or any other similar state laws based on the Uniform Electronic Transactions Act. 
 (l) Defaulting Lenders. In
connection with any assignment of rights and obligations of any Defaulting Lender hereunder, no such assignment shall be effective unless and until, in addition to the other conditions thereto set forth herein, the parties to the assignment shall
make such additional payments to the Administrative Agent in an aggregate amount sufficient, upon distribution thereof as appropriate (which may be outright payment, purchases by the assignee of 

  
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participations or subparticipations, or other compensating actions, including funding, with the consent of the Borrowers and the Administrative Agent, the applicable pro rata share of Loans
previously requested but not funded by the Defaulting Lender, to each of which the applicable assignee and assignor hereby irrevocably consent), to (x) pay and satisfy in full all payment liabilities then owed by such Defaulting Lender to the
Administrative Agent or any Lender hereunder (and interest accrued thereon) and (y) acquire (and fund as appropriate) its full pro rata share of all Loans and participations in Letters of Credit in accordance with its Pro Rata Share.
Notwithstanding the foregoing, in the event that any assignment of rights and obligations of any Defaulting Lender hereunder shall become effective under applicable Law without compliance with the provisions of this Section 11.06(l),
then the assignee of such interest shall be deemed to be a Defaulting Lender for all purposes of this Agreement until such compliance occurs. 
 11.07
Treatment of Certain Information; Confidentiality. 
 Each of the Agents, the L/C Issuer and Lenders agrees to maintain, and to cause
its Affiliates (including any Related Parties) to maintain, the confidentiality of the Information (as defined below), except that Information may be disclosed (a) to its Affiliates and to its and its Affiliates’ respective partners,
directors, officers, employees, agents, advisors and representatives (it being understood that the Persons to whom such disclosure is made will be informed of the confidential nature of such Information and instructed to keep such Information
confidential); (b) to the extent requested by any regulatory authority purporting to have jurisdiction over it (including any self-regulatory authority, such as the National Association of Insurance Commissioners); (c) to the extent
required by applicable laws or regulations or by any subpoena or similar legal process; (d) to any other party hereto; (e) to the extent reasonably required, in connection with the exercise of any remedies hereunder or under any other Loan
Document or any action or proceeding relating to this Agreement or any other Loan Document or the enforcement of rights hereunder or thereunder; (f) subject to an agreement containing provisions substantially the same as those of this Section,
to (i) any assignee of or Participant in, or any prospective assignee of or Participant in, any of its rights or obligations under this Agreement, or (ii) any actual or prospective counterparty (or its advisors) to any swap or derivative
transaction relating to obligations of the Loan Parties under the Loan Documents; (g) with the consent of the Company; or (h) to the extent such Information (i) becomes publicly available other than as a result of a breach of this
Section or (ii) becomes available to any Agent, the L/C Issuer, any Lender or any of their respective Affiliates on a nonconfidential basis from a source other than the Company; provided, however, that to the extent permitted by
applicable law or regulation, each of the Agents and Lenders agrees to notify the Company prior to (if reasonably practicable) or concurrently with its disclosure of such information to any third party pursuant to clauses (b), (c) and (f). In
addition, the Administrative Agent and the Lenders may disclose the existence of this Agreement and public information about this Agreement to market data collectors, similar service providers to the lending industry, and service providers to the
Administrative Agent and the Lenders in connection with the administration and management of this Agreement, the other Loan Documents, the Commitments, and the Credit Extensions. 

For the purposes of this Section, “Information” means all information received from any Loan Party relating to any Loan Party
or its business, other than any such information that is available to any Agent, the L/C Issuer, or any Lender or any of their respective Affiliates on a nonconfidential basis prior to disclosure by any Loan Party; provided that, in the case
of any information received from a Loan Party after the date hereof (other than in connection with Section 6.03, all of which is acknowledged to constitute “Information” regardless of any marking as confidential), such
information is clearly identified at the time of delivery as confidential. Any Person required to maintain the confidentiality of Information as provided in this Section shall be considered to have complied with its obligation to do so if such
Person has exercised the same degree of care to maintain the confidentiality of such Information as such Person would accord to its own confidential information. 

  
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 Each of the Agents and each of the Lenders acknowledges that (a) the Information may include
material non-public information concerning the Borrowers or a Subsidiary, as the case may be, (b) it has developed compliance procedures regarding the use of material non-public information and (c) it will handle such material non-public
information in accordance with applicable Law, including United States federal and state securities Laws. 
 11.08 Set-off. In addition to any rights
and remedies of the Lenders provided by law, upon the occurrence and during the continuance of any Event of Default, each Lender is authorized at any time and from time to time, without prior notice to the Borrowers, any such notice being waived by
the Borrowers to the fullest extent permitted by law, to set off and apply any and all deposits (general or special, time or demand, provisional or final) at any time held by, and other indebtedness at any time owing by, such Lender to or for the
credit or the account of the respective Loan Parties against any and all Obligations owing to such Lender hereunder or under any other Loan Document, now or hereafter existing, irrespective of whether or not the Administrative Agent or such Lender
shall have made demand under this Agreement or any other Loan Document and although such Obligations may be contingent or unmatured or denominated in a currency different from that of the applicable deposit or indebtedness. Each Lender agrees
promptly to notify the Borrowers and the Administrative Agent after any such set-off and application made by such Lender; provided, however, that (i) the failure to give such notice shall not affect the validity of such set-off and
application and (ii) in the event that any Defaulting Lender shall exercise any such right of setoff, (x) all amounts so set off shall be paid over immediately to the Administrative Agent for further application in accordance with the
provisions of Section 2.18 and, pending such payment, shall be segregated by such Defaulting Lender from its other funds and deemed held in trust for the benefit of the Administrative Agent and the Lenders, and (y) the Defaulting
Lender shall provide promptly to the Administrative Agent a statement describing in reasonable detail the Obligations owing to such Defaulting Lender as to which it exercised such right of setoff. 

11.09 Interest Rate Limitation. Notwithstanding anything to the contrary contained in any Loan Document, the interest paid or agreed to be paid under
the Loan Documents shall not exceed the maximum rate of non-usurious interest permitted by applicable Law (the “Maximum Rate”). If either Agent or any Lender shall receive interest in an amount that exceeds the Maximum Rate, the
excess interest shall be applied to the principal of the Loans or, if it exceeds such unpaid principal, refunded to the Applicable Borrower. In determining whether the interest contracted for, charged, or received by the Administrative Agent or a
Lender exceeds the Maximum Rate, such Person may, to the extent permitted by applicable Law, (a) characterize any payment that is not principal as an expense, fee, or premium rather than interest, (b) exclude voluntary prepayments and the
effects thereof, and (c) amortize, prorate, allocate, and spread in equal or unequal parts the total amount of interest throughout the contemplated term of the Obligations hereunder. 

11.10 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument. 
 11.11 Integration. This Agreement, together with the other Loan Documents, comprises the complete
and integrated agreement of the parties on the subject matter hereof and thereof and supersedes all prior agreements, written or oral, on such subject matter. In the event of any conflict between the provisions of this Agreement and those of any
other Loan Document, the provisions of this Agreement shall control; provided that the inclusion of supplemental rights or remedies in favor of the Agents or the Lenders in any other Loan Document shall not be deemed a conflict with this
Agreement. Each Loan Document was drafted with the joint participation of the respective parties thereto and shall be construed neither against nor in favor of any party, but rather in accordance with the fair meaning thereof. 

  
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 11.12 Survival of Representations and Warranties. All representations and warranties made hereunder and in
any other Loan Document or other document delivered pursuant hereto or thereto or in connection herewith or therewith shall survive the execution and delivery hereof and thereof. Such representations and warranties have been or will be relied upon
by each Agent and each Lender, regardless of any investigation made by either Agent or any Lender or on their behalf and notwithstanding that either Agent or any Lender may have had notice or knowledge of any Default at the time of any Credit
Extension, and shall continue in full force and effect as long as any Loan or any other Obligation hereunder shall remain unpaid or unsatisfied or any Letter of Credit shall remain outstanding. 

11.13 Severability. If any provision of this Agreement or the other Loan Documents is held to be illegal, invalid or unenforceable, (a) the
legality, validity and enforceability of the remaining provisions of this Agreement and the other Loan Documents shall not be affected or impaired thereby and (b) the parties shall endeavor in good faith negotiations to replace the illegal,
invalid or unenforceable provisions with valid provisions the economic effect of which comes as close as possible to that of the illegal, invalid or unenforceable provisions. The invalidity of a provision in a particular jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction. 
 11.14 Tax Forms. (a) (i) Each Lender that is not a
“United States person” within the meaning of Section 7701(a)(30) of the Code (a “Foreign Lender”) shall deliver to the Administrative Agent, prior to receipt of any payment subject to withholding under the Code (or
upon accepting an assignment of an interest herein), two duly signed completed copies of either IRS Form W-8BEN or any successor thereto (relating to such Foreign Lender and entitling it to an exemption from, or reduction of, withholding tax on all
payments to be made to such Foreign Lender by the Company pursuant to this Agreement) or IRS Form W-8ECI or any successor thereto (relating to all payments to be made to such Foreign Lender by the Borrowers pursuant to this Agreement) and such other
evidence satisfactory to the Company and the Administrative Agent that such Foreign Lender is entitled to an exemption from, or reduction of, U.S. withholding tax, including any exemption pursuant to Section 881(c) of the Code. Thereafter and
from time to time, each such Foreign Lender shall (A) promptly submit to the Administrative Agent such additional duly completed and signed copies of one of such forms (or such successor forms as shall be adopted from time to time by the
relevant United States taxing authorities) as may then be available under then current United States laws and regulations to avoid, or such evidence as is satisfactory to the Company and the Administrative Agent of any available exemption from or
reduction of, United States withholding taxes in respect of all payments to be made to such Foreign Lender by the Company pursuant to this Agreement, (B) promptly notify the Administrative Agent of any change in circumstances which would modify
or render invalid any claimed exemption or reduction, and (C) take such steps as shall not be materially disadvantageous to it, in the reasonable judgment of such Lender, and as may be reasonably necessary (including the re-designation of its
Lending Office) to avoid any requirement of applicable Laws that the Company make any deduction or withholding for taxes from amounts payable to such Foreign Lender. 

(ii) Each Foreign Lender, to the extent it does not act or ceases to act for its own account with respect to any portion of any sums paid or
payable to such Lender under any of the Loan Documents (for example, in the case of a typical participation by such Lender), shall deliver to the Administrative Agent on the date when such Foreign Lender ceases to act for its own account with
respect to any portion of any such sums paid or payable, and at such other times as may be necessary in the determination of the Administrative Agent (in the reasonable exercise of its discretion), (A) two duly signed completed copies of the
forms or statements required to be provided by such Lender as set forth above, to establish the portion of any such sums paid or payable with respect to which such Lender acts for its own account that is not subject to U.S. withholding tax, and
(B) two duly signed completed copies of IRS Form W-8IMY 

  
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(or any successor thereto), together with any information such Lender chooses to transmit with such form, and any other certificate or statement of exemption required under the Code, to establish
that such Lender is not acting for its own account with respect to a portion of any such sums payable to such Lender. 
 (iii) The Company
shall not be required to pay any additional amount to or indemnify any Foreign Lender under Section 3.01 (A) with respect to any Taxes required to be deducted or withheld on the basis of the information, certificates or statements
of exemption such Lender transmits with an IRS Form W-8IMY pursuant to this Section 11.14(a) (other than with respect to the portion of any sums paid or payable to such Lender under any of the Loan Documents with respect to which such
Lender acts for its own account) or (B) to the extent that the obligation to pay or indemnify such additional amounts would not have arisen but for the failure of such Foreign Lender to comply with the provisions of
Section 11.14(a); provided that if such Lender shall have satisfied the requirement of this Section 11.14(a) effective as of the date such Lender became a Lender or ceased to act for its own account with respect to any
payment under any of the Loan Documents, nothing in this Section 11.14(a) shall relieve the Company of its obligation to pay any amounts pursuant to Section 3.01 in the event that, as a result of any subsequent change in any
applicable law, treaty or governmental rule, regulation or order, or any subsequent change in the interpretation, administration or application thereof, such Lender is no longer properly entitled to deliver forms, certificates or other evidence at a
subsequent date establishing the fact that such Lender or other Person for the account of which such Lender receives any sums payable under any of the Loan Documents is not subject to withholding or is subject to withholding at a reduced rate. 

(iv) The Administrative Agent may, without reduction, withhold any Taxes required to be deducted and withheld from any payment under any of
the Loan Documents with respect to which the Company is not required to pay additional amounts under this Section 11.14(a). 

(b) Upon the request of the Administrative Agent, each Lender that is a “United States person” within the meaning of
Section 7701(a)(30) of the Code shall deliver to the Administrative Agent two duly signed completed copies of IRS Form W-9. If such Lender fails to deliver such forms, then the Administrative Agent may withhold from any interest payment to such
Lender an amount equivalent to the applicable back-up withholding tax imposed by the Code, without reduction. 
 (c) If a payment made to a
Lender under any Loan Document would be subject to U.S. federal withholding Tax imposed by FATCA if such Lender were to fail to comply with the applicable reporting requirements of FATCA (including those contained in Section 1471(b) or 1472(b)
of the Code, as applicable), such Lender shall deliver to the Borrower and the Administrative Agent at the time or times prescribed by law and at such time or times reasonably requested by the Borrower or the Administrative Agent such documentation
prescribed by applicable law (including as prescribed by Section 1471(b)(3)(C)(i) of the Code) and such additional documentation reasonably requested by the Borrower or the Administrative Agent as may be necessary for the Borrower and the
Administrative Agent to comply with their obligations under FATCA and to determine that such Lender has complied with such Lender’s obligations under FATCA or to determine the amount to deduct and withhold from such payment. Solely for purposes
of this clause (c), “FATCA” shall include any amendments made to FATCA after the date of this Agreement. 

  
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 (d) Without duplication of Sections 11.14(a), Section 11.14(b) or
Section 11.14(c), any Lender that is entitled to an exemption from or reduction of withholding Tax with respect to payments made under any Loan Document shall deliver to the Borrower and the Administrative Agent, at the time or times
reasonably requested by the Borrower or the Administrative Agent, such properly completed and executed documentation reasonably requested by the Borrower or the Administrative Agent as will permit such payments to be made without withholding or at a
reduced rate of withholding. In addition, any Lender, if reasonably requested by the Borrower or the Administrative Agent, shall deliver such other documentation prescribed by applicable law or reasonably requested by the Borrower or the
Administrative Agent as will enable the Borrower or the Administrative Agent to determine whether or not such Lender is subject to backup withholding or information reporting requirements. Notwithstanding anything to the contrary in the preceding
two sentences, the completion, execution and submission of such documentation (other than such documentation identified in Sections 11.14(a), Section 11.14(b) or Section 11.14(c)) shall not be required if in the
Lender’s reasonable judgment such completion, execution or submission would subject such Lender to any material unreimbursed cost or expense or would materially prejudice the legal or commercial position of such Lender. Each Lender agrees that
if any form or certification it previously delivered expires or becomes obsolete or inaccurate in any respect, it shall update such form or certification or promptly notify the Borrower and the Administrative Agent in writing of its legal inability
to do so. 
 (e) If any Governmental Authority asserts that the Administrative Agent did not properly withhold or backup withhold, as the
case may be, any tax or other amount from payments made to or for the account of any Lender, such Lender shall indemnify the Administrative Agent therefor, including all penalties and interest, any taxes imposed by any jurisdiction on the amounts
payable to the Administrative Agent under this Section 11.14, and costs and expenses (including Attorney Costs) of the Administrative Agent. The obligation of the Lenders under this Section 11.14 shall survive the termination
of the Aggregate Commitments, repayment of all other Obligations hereunder and the resignation of the Administrative Agent. 
 (f) Each
Canadian Lender hereby represents and warrants that it is a Canadian Resident, and each Canadian Lender agrees that if the foregoing representation is inaccurate with respect to such Canadian Lender in any material respect, then the Applicable
Borrower shall not be required to pay to such Canadian Lender any amounts pursuant to Section 3.01 relating to any Taxes resulting solely from such inaccuracy. If a Borrower is required to pay amounts to any Canadian Lender pursuant to
Section 3.01 (whether by reason of such Canadian Lender’s change of status or otherwise), then such Canadian Lender shall use reasonable efforts (consistent with legal and regulatory restrictions) to take such actions as are
necessary to minimize such Borrower’s obligations under Article III, if such actions, in the sole judgment of such Canadian Lender, are not otherwise disadvantageous to such Canadian Lender. 

(g) Each Lender shall severally indemnify the Borrowers and Applicable Agent, within ten days after demand therefor, for any and all Taxes and
any and all related losses, claims, liabilities, penalties, interest and expenses (including the fees, charges and disbursements 

  
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of any counsel for the Borrowers or Applicable Agent) incurred by or asserted against the Borrowers or the Applicable Agent by any Governmental Authority as a result of the failure by such Lender
to deliver, or as a result of the inaccuracy or similar deficiency of any documentation required to be delivered by such Lender to the Borrowers or Applicable Agent pursuant to Section 11.14. Each Lender shall severally indemnify the
Applicable Agent, within 10 days after demand therefor, for (i) any Taxes attributable to such Lender (but only to the extent that the Borrower has not already indemnified the Applicable Agent for such Taxes and without limiting the obligation
of the Borrower to do so), (ii) any taxes attributable to such Lender’s failure to comply with the provisions of Section 11.06(d)(ii) relating to the maintenance of a Participant Register and (iii) any Excluded Taxes attributable
to such Lender, in each case, that are payable or paid by the Administrative Agent in connection with any Loan Document, and any and all related losses, claims, liabilities, penalties, interest and expenses (including the fees, charges and
disbursements of any counsel for the Applicable Agent), whether or not such taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. A certificate as to the amount of such payment or liability delivered to any
Lender by the Administrative Agent shall be conclusive absent manifest error. Each Lender hereby authorizes the Administrative Agent to set off and apply any and all amounts at any time owing to such Lender under any Loan Document or otherwise
payable by the Administrative Agent to the Lender from any other source against any amount due to the Administrative Agent under this paragraph (g). The agreements in this Section 11.14(g) will survive the resignation and/or replacement
of Agent, any assignment of rights by, or the replacement of, a Lender, the termination of the Commitments and the repayment, satisfaction or discharge of all other Obligations. 

11.15 Replacement of Lenders. If (i) any Lender requests compensation under Section 3.04, (ii) a Borrower is required to pay any
additional amount to any Lender or any Governmental Authority for the account of any Lender pursuant to Section 3.01, (iii) any Lender is a Non-Extending Lender for any extension of the Maturity Date, (iv) any Lender is a
“Defaulting Lender” or (v) any other circumstance exists hereunder that gives any Borrower the right to replace a Lender as a party hereto, then such Borrower may, at its sole expense and effort, upon notice to such Lender and the
Agents, require such Lender to assign and delegate, without recourse (in accordance with and subject to the restrictions contained in, and consents required by, Section 11.06), all of its interests, rights and obligations under this
Agreement and the related Loan Documents to an assignee that shall assume such obligations (which assignee may be another Lender, if a Lender accepts such assignment), provided that: 

(a) the Company shall have paid to the Administrative Agent the assignment fee specified in Section 11.06(b); 

(b) such Lender shall have received payment of an amount equal to the outstanding principal of its Loans and L/C Advances, accrued interest
thereon, accrued fees and all other amounts payable to it hereunder and under the other Loan Documents (including any amounts under Section 3.05) from the assignee (to the extent of such outstanding principal and accrued interest and
fees) or the Company (in the case of all other amounts); 
 (c) in the case of any such assignment resulting from a claim for compensation
under Section 3.04 or payments required to be made pursuant to Section 3.01, such assignment will result in a reduction in such compensation or payments thereafter; and 

  
 98 

 (d) such assignment does not conflict with applicable Laws. 

A Lender shall not be required to make any such assignment or delegation if, prior thereto, as a result of a waiver by such Lender or
otherwise, the circumstances entitling the Company to require such assignment and delegation cease to apply. 
 11.16 Governing Law. 

(a) THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK APPLICABLE TO AGREEMENTS MADE AND
TO BE PERFORMED ENTIRELY WITHIN SUCH STATE; PROVIDED THAT THE AGENTS, THE L/C ISSUER AND EACH LENDER SHALL RETAIN ALL RIGHTS ARISING UNDER FEDERAL LAW. 

(b) ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT MAY BE BROUGHT IN THE COURTS OF THE STATE OF NEW
YORK OR OF THE UNITED STATES FOR THE SOUTHERN DISTRICT OF SUCH STATE, AND BY EXECUTION AND DELIVERY OF THIS AGREEMENT, THE BORROWERS, THE AGENTS, THE L/C ISSUER AND EACH LENDER CONSENTS, FOR ITSELF AND IN RESPECT OF ITS PROPERTY, TO THE EXCLUSIVE
JURISDICTION OF THOSE COURTS. THE BORROWERS, THE AGENTS, THE L/C ISSUER AND EACH LENDER IRREVOCABLY WAIVES ANY OBJECTION, INCLUDING ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, WHICH IT MAY NOW OR
HEREAFTER HAVE TO THE BRINGING OF ANY ACTION OR PROCEEDING IN SUCH JURISDICTION IN RESPECT OF ANY LOAN DOCUMENT OR OTHER DOCUMENT RELATED THERETO. THE BORROWERS, THE AGENTS, THE L/C ISSUER AND EACH LENDER WAIVES PERSONAL SERVICE OF ANY SUMMONS,
COMPLAINT OR OTHER PROCESS, WHICH MAY BE MADE BY ANY OTHER MEANS PERMITTED BY THE LAW OF SUCH STATE. 
 (c) The Borrowers expressly require
that this document and all documents accessory hereto be drawn up in English and each Agent and each Lender, because of the customer’s requirement and by making such documents available to the customer in the English language, expresses the
same requirement. 
 Les Emprunteurs requièrent expressément que ce document et tous les documents qui s’y rapportent
soient rédigés en langue anglaise et chaque Mondataire et chaque Banque, à cause de cette exigence du client, exprime la même volonté en faisant en sorte que les documents en langue anglaise soient à la
disposition du client. 
 11.17 Waiver of Right to Trial by Jury. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY
APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY (WHETHER BASED ON
CONTRACT, TORT OR ANY OTHER THEORY). EACH PARTY HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PERSON HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PERSON WOULD NOT, IN

  
 99 

 
THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER AND (B) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER INTO THIS AGREEMENT AND THE OTHER LOAN
DOCUMENTS BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION. 
 11.18 No Advisory or Fiduciary Responsibility. In
connection with all aspects of each transaction contemplated hereby (including in connection with any amendment, waiver or other modification hereof or of any other Loan Document), each Borrower and each other Loan Party acknowledges and agrees, and
acknowledges its Affiliates’ understanding, that: (i) (A) the arranging and other services regarding this Agreement provided by the Agents, the Lenders and the Arranger are arm’s-length commercial transactions between the
Borrowers, each other Loan Party and their respective Affiliates, on the one hand, and the Agents, the Lenders and the Arranger, on the other hand, (B) such Borrower and each other Loan Party has consulted its own legal, accounting, regulatory
and tax advisors to the extent it has deemed appropriate, and (C) such Borrower and each other Loan Party is capable of evaluating, and understands and accepts, the terms, risks and conditions of the transactions contemplated hereby and by the
other Loan Documents; (ii) (A) each of the Agents, the Lenders and the Arranger is and has been acting solely as a principal and, except as expressly agreed in writing by the relevant parties, has not been, is not, and will not be acting
as an advisor, agent or fiduciary for any Borrower, any other Loan Party or any of their respective Affiliates, or any other Person and (B) none of the Agents nor the Lenders nor the Arranger has any obligation to any Borrower, any other Loan
Party or any of their respective Affiliates with respect to the transactions contemplated hereby except those obligations expressly set forth herein and in the other Loan Documents; and (iii) the Agents, the Lenders and the Arranger and their
respective Affiliates may be engaged in a broad range of transactions that involve interests that differ from those of the Borrowers, the other Loan Parties and their respective Affiliates, and none of the Agents nor the Lenders nor the Arranger has
any obligation to disclose any of such interests to any Borrower, any other Loan Party or any of their respective Affiliates. To the fullest extent permitted by law, each of the Borrowers and the other Loan Parties hereby waives and releases any
claims that it may have against any of the Agents, the Lenders or the Arranger with respect to any breach or alleged breach of agency or fiduciary duty in connection with any aspect of any transaction contemplated hereby. 

11.19 USA Patriot Act Notice. Each Lender that is subject to the Act (as hereinafter defined) and the Administrative Agent (for itself and not on
behalf of any Lender) hereby notifies the Borrowers that pursuant to the requirements of the USA Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Act”), it is required to obtain, verify and
record information that identifies the Borrowers, which information includes the name and address of the Borrowers and other information that will allow such Lender or the Administrative Agent, as applicable, to identify the Borrowers in accordance
with the Act. 
 11.20 Judgment. If, for the purposes of obtaining judgment in any court, it is necessary to convert a sum due hereunder or any other
Loan Document in one currency into another currency, the rate of exchange used shall be that at which in accordance with normal banking procedures the Administrative Agent could purchase the first currency with such other currency on the Business
Day preceding that on which final judgment is given. The obligation of a Borrower in respect of any such sum due from it to the Administrative Agent hereunder or under the other Loan Documents shall, notwithstanding any judgment in a currency (the
“Judgment Currency”) other than that in which such sum is denominated in accordance with the applicable provisions of this Agreement (the “Agreement Currency”), be discharged only to the extent that on the Business
Day following receipt by the Administrative Agent of any sum adjudged to be so due in the Judgment Currency, the Administrative Agent may in accordance with normal banking procedures purchase the Agreement Currency with the Judgment Currency. If the
amount of the Agreement Currency so purchased is less than the sum originally due to the Administrative Agent in the Agreement Currency, the Borrowers agree, as a separate obligation and notwithstanding any such

  
 100 

 
judgment, jointly and severally, to indemnify the Administrative Agent or the Person to whom such obligation was owing against such loss. If the amount of the Agreement currency so purchased is
greater than the sum originally due to the Administrative Agent in such currency, the Administrative Agent agrees to return the amount of any excess to the Applicable Borrower (or to any other Person who may be entitled thereto under applicable
law). 
 11.21 Limitation of McKesson Canada Liability. Notwithstanding anything to the contrary herein contained, the liability of McKesson Canada
hereunder and under any other Loan Documents shall be limited to the Obligations of McKesson Canada, and McKesson Canada shall have no liability whatsoever under the Loan Documents with respect to any Obligations of the Domestic Borrowers. 

  
 101 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as
of the date first above written. 
  

			
	MCKESSON CORPORATION
		
	By:	 	 /s/ Nicholas A. Loiacono

		 	Name: Nicholas A. Loiacono
		 	Title: Vice President and Treasurer

  

			
	MCKESSON CANADA CORPORATION
		
	By:	 	 /s/ Paula Keays

		 	Name: Paula Keays
		 	Title: Vice President Finance, Chief Financial Officer and Assistant Treasurer

 BANK OF AMERICA, N.A., as Administrative Agent 

 

			
	 By:
	 	 /s/ Zubin R. Shroff

		 	Name: Zubin R. Shroff
		 	Title: Director
	
	 BANK OF AMERICA, N.A., as a Lender

		
	By:	 	 /s/ Zubin R. Shroff

		 	Name: Zubin R. Shroff
		 	Title: Director

 BANK OF AMERICA, N.A. (acting through its Canada branch), as Canadian Administrative Agent 

 

			
	By:	 	 /s/ Medina Sales de Andrade

		 	Name: Medina Sales de Andrade
		 	Title: Vice President

 BANK OF AMERICA, N.A. (acting through its Canada branch), as Canadian Lender 

 

			
	By:	 	 /s/ Medina Sales de Andrade

		 	Name: Medina Sales de Andrade
		 	Title: Vice President

 WELLS FARGO BANK, NATIONAL ASSOCIATION, as L/C Issuer 

 

			
	By:	 	 /s/ Kirk Tesch

		 	Name: Kirk Tesch
		 	Title: Director

 WELLS FARGO BANK, NATIONAL ASSOCIATION, as Lender 
  

			
	By:	 	 /s/ Kirk Tesch

		 	Name: Kirk Tesch
		 	Title: Director

			
	JPMORGAN CHASE BANK, N.A.
		
	By:	 	 /s/ Vanessa Chiu

		 	Name: Vanessa Chiu
		 	Title: Executive Director

			
	THE BANK OF TOKYO-MITSUBISHI UFJ, LTD.
		
	By:	 	 /s/ Victor Pierzchalski

		 	Name: Victor Pierzchalski
		 	Title: Authorized Signatory

			
	THE BANK OF NOVA SCOTIA
		
	By:	 	 /s/ Diane Emanuel

		 	Name: Diane Emanuel
		 	Title: Managing Director

			
	 U.S. BANK NATIONAL ASSOCIATION

		
	 By:
	 	 /s/ Janet E. Jordan

		 	Name: Janet E. Jordan
		 	Title: Senior Vice President

 U.S. BANK NATIONAL ASSOCIATION, Canada Branch 

 

			
	 By:
	 	 /s/ Joseph Rauhala

		 	Name: Joseph Rauhala
		 	Title: Principal Officer

 COÖPERATIEVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A. 

“RABOBANK NEDERLAND”, NEW YORK BRANCH 
  

			
	 By:
	 	 /s/ Steven Cashiola

		 	Name: Steven Cashiola
		 	Title: Vice President
		
	 By:
	 	 /s/ Sue Chen-Holmes

		 	Name: Sue Chen-Holmes
		 	Title: Vice President

 GOLDMAN SACHS BANK USA 
  

			
	By:	 	 /s/ Anna Ostrovsky

		 	Name: Anna Ostrovsky
		 	Title: Authorized Signatory

 PNC BANK, NATIONAL ASSOCIATION 
  

			
	By:	 	 /s/ Philip K. Liebscher

		 	Name: Philip K. Liebscher
		 	Title: Senior Vice President

 FIFTH THIRD BANK 
  

			
	By:	 	 /s/ Mitchell E. Gruesen

		 	Name: Mitchell E. Gruesen
		 	Title: Officer

 HSBC BANK USA, NATIONAL ASSOCIATION 
  

			
	By:	 	 /s/ Ted Olson

		 	Name: Ted Olson
		 	Title: Vice President

 TORONTO DOMINION (TEXAS) LLC 
  

			
	By:	 	 /s/ Debbi L. Brito

		 	Name: Debbi L. Brito
		 	Title: Authorized Signatory

 THE TORONTO-DOMINION BANK 
  

			
	By:	 	 /s/ Debbi L. Brito

		 	Name: Debbi L. Brito
		 	Title: Authorized Signatory

 LLOYDS TSB BANK PLC 
  

			
	By:	 	 /s/ Windsor Davies

		 	Name: Windsor Davies
		 	Title: Managing Director

 LLOYDS TSB BANK PLC 
  

			
	 By:
	 	 /s/ Charles Foster

		 	Name: Charles Foster
		 	Title: Managing Director

 SCHEDULE 2.01 

COMMITMENTS, PRO RATA SHARES AND AFFILIATE BANKS 
  

																			
	 Domestic Lender
	  	Canadian
Lender	 	Canadian
Commitments
(in U.S. Dollars)	 	  	Canadian Pro Rata
Share	 	 	Total Commitment	 	  	Total Pro Rata
Share	 
	 BANK OF AMERICA, N.A.
	  	BANK OF
 AMERICA, N.A. (acting
through its Canada

Branch)
	 	$	54,500,000	  	  	 	27.250000000	%	 	$	200,000,000	  	  	 	15.384615384	%
	 WELLS FARGO BANK, NATIONAL ASSOCIATION
	  		 	$	0	  	  				 	$	175,000,000	  	  	 	13.461538461	%
	JPMORGAN CHASE BANK, N.A.	  	JPMORGAN CHASE
BANK, N.A.	 	$	50,000,000	  	  	 	25.000000000	%	 	$	175,000,000	  	  	 	13.461538461	%
	 THE BANK OF TOKYO-MITSUBISHI UFJ, LTD.
	  		 	$	0	  	  				 	$	100,000,000	  	  	 	7.692307692	%
	 THE BANK OF NOVA SCOTIA
	  	THE BANK OF NOVA
SCOTIA	 	$	30,000,000	  	  	 	15.000000000	%	 	$	100,000,000	  	  	 	7.692307692	%
	 U.S. BANK NATIONAL ASSOCIATION
	  	U.S. BANK NATIONAL
ASSOCIATION,
CANADA BRANCH	 	$	30,000,000	  	  	 	15.000000000	%	 	$	100,000,000	  	  	 	7.692307692	%
	 COÖPERATIEVE CENTRALE RAIFFEISEN-BOERENLEENBANK B.A. “RABOBANK NEDERLAND”, NEW YORK BRANCH
	  		 	$	0	  	  				 	$	70,000,000	  	  	 	5.384615384	%
	 GOLDMAN SACHS BANK USA
	  		 	$	0	  	  				 	$	70,000,000	  	  	 	5.384615384	%
	 PNC BANK, NATIONAL ASSOCIATION
	  		 	$	0	  	  				 	$	70,000,000	  	  	 	5.384615384	%
	 FIFTH THIRD BANK
	  		 	$	0	  	  				 	$	70,000,000	  	  	 	5.384615384	%
	 HSBC BANK USA, NATIONAL ASSOCIATION
	  	HSBC BANK USA,
NATIONAL
ASSOCIATION	 	$	10,500,000	  	  	 	5.250000000	%	 	$	70,000,000	  	  	 	5.384615384	%
	 TORONTO DOMINION (TEXAS) LLC
	  	THE TORONTO-
DOMINION BANK	 	$	25,000,000	  	  	 	12.500000000	%	 	$	50,000,000	  	  	 	3.846153846	%
	 LLOYDS TSB BANK PLC
	  		 	$	0	  	  				 	$	50,000,000	  	  	 	3.846153846	%
		  		 	  
	  
	 	  	  
	  
	 	 	  
	  
	 	  	  
	  
	 
	 Totals:
	  		 	$	200,000,000	  	  	 	100.000000000	%	 	$	1,300,000,000	  	  	 	100.000000000	%
		  		 	  
	  
	 	  	  
	  
	 	 	  
	  
	 	  	  
	  
	 

  
 Schedule 2.01-1 

 SCHEDULE 5.11 

SUBSIDIARIES OF THE COMPANY 
  

			
	3071406 Nova Scotia Company	  	Iowa Pharmaceutical Services, LLC
		
	A.L.I. Technologies (Deutschland) Gmbh	  	IQ Systems Services
		
	AccessMed Holdings, LLC	  	KCCC JV, LLC
		
	AccessMed, LLC	  	KWS & P/SFA, Inc.
		
	AOR Holding Company of Indiana, LLC	  	Liquidlogic Limited
		
	AOR Management Company of Arizona, LLC	  	McKesson (Shanghai) Trading Company Limited
		
	AOR Management Company of Indiana, LLC	  	McKesson Automation Canada Company
		
	AOR Management Company of Missouri, LLC	  	McKesson Automation Inc.
		
	AOR Management Company of Oklahoma, LLC	  	McKesson Automation Systems Inc.
		
	AOR Management Company of Pennsylvania,	  	McKesson Canada Corporation
		
	LLC	  	McKesson Canada Support Services Corporation
		
	AOR Management Company of Virginia, LLC	  	McKesson Capital Funding Corporation
		
	AOR of Indiana Management Partnership	  	McKesson Capital LLC
		
	AOR of Texas Management, LLC	  	McKesson Central Fill LLC
		
	AOR Real Estate, LLC	  	McKesson China Holdings S.a.r.l.
		
	AOR Synthetic Real Estate, LLC	  	McKesson Financial Holdings
		
	AORT Holding Company, Inc.	  	McKesson Financial Holdings II
		
	Beldere Corporation	  	McKesson Funding Company of Canada
		
	Bluestar Group	  	McKesson Health Solutions Holdings LLC
		
	Cancer Treatment Associates of Northeast	  	McKesson Health Solutions LLC
		
	Missouri, Ltd.	  	McKesson Health Solutions Puerto Rico Inc.
		
	Care Records Ltd.	  	McKesson High Volume Solutions Inc.
		
	CCCN NW Building JV, LLC	  	McKesson Information Solutions Canada
		
	CGSF Funding Corporation	  	Company
		
	Clinique Santé Corporation	  	McKesson Information Solutions Capital S.a.r.l.
		
	Colorado Cancer Centers, LLC	  	McKesson Information Solutions Finance S.a.r.l.
		
	Conscia Enterprise Systems	  	McKesson Information Solutions France S.A.S.
		
	Crocker Plaza Company	  	McKesson Information Solutions Holdings
		
	Cypress Medical Products LLC	  	France S.a.r.l.
		
	D & K Healthcare Resources LLC	  	McKesson Information Solutions Holdings
		
	Delta Clinical Research, LLC	  	S.a.r.l.
		
	East Indy CC, LLC	  	McKesson Information Solutions Netherlands
		
	Foremost de Venezuela, S.A.	  	B.V.
		
	Foremost Iran Corporation	  	McKesson Information Solutions Sweden AB
		
	Foremost Shir, Inc.	  	McKesson Information Solutions Topholdings
		
	Foremost Tehran, Inc.	  	S.a r.l.
		
	Golden State Corporate Services LLC	  	McKesson Information Solutions UK Limited
		
	Golden State Insurance Company Limited	  	McKesson International Bermuda IP2A Limited
		
	Greenville Radiation Care, Inc.	  	McKesson International Bermuda IP2B
		
	HBOC Medical Limited	  	Unlimited
		
	Health Mart Systems, Inc.	  	McKesson International Bermuda IP3A Limited
		
	HF Land Company	  	McKesson International Bermuda IP3B
		
	Innovent Oncology, LLC	  	Unlimited

  
 Schedule 5.11-1 

			
	McKesson International Bermuda IP4A Limited	  	McKesson Medical-Surgical Minnesota Inc.
		
	McKesson International Bermuda IP4B	  	McKesson Medical-Surgical Minnesota Supply
		
	Unlimited	  	Inc.
		
	McKesson International Bermuda IP5A Limited	  	McKesson Nederland B.V.
		
	McKesson International Bermuda IP5B	  	McKesson Pharmaceutical Holdings LLC
		
	Unlimited	  	McKesson Pharmacy Optimization LLC
		
	McKesson International Bermuda Opco1A	  	McKesson Pharmacy Systems Canada ULC
		
	Limited	  	McKesson Pharmacy Systems LLC
		
	McKesson International Bermuda Opco1B	  	McKesson Plasma and Biologics LLC
		
	Unlimited	  	McKesson Property Company, Inc.
		
	McKesson International Bermuda Opco3A	  	McKesson Specialty Arizona Inc.
		
	Limited	  	McKesson Specialty Care Distribution
		
	McKesson International Bermuda Opco3B	  	Corporation
		
	Unlimited	  	McKesson Specialty Care Distribution Joint
		
	McKesson International Bermuda Opco4A	  	Venture LP
		
	Limited	  	McKesson Specialty Distribution LLC
		
	McKesson International Bermuda Opco4B	  	McKesson Specialty Holdings LLC
		
	Unlimited	  	McKesson Specialty Prescription Services (Atlantic)
		
	McKesson International Capital S.a.r.l.	  	Corporation
		
	McKesson International Finance S.a.r.l.	  	McKesson Specialty Prescription Services (B.C.)
		
	McKesson International Holdings	  	Corporation
		
	McKesson International Holdings II S.a.r.l.	  	McKesson Specialty Prescription Services
		
	McKesson International Holdings III S.a.r.l.	  	Corporation
		
	McKesson International Holdings IV S.a.r.l.	  	McKesson Technologies Inc.
		
	McKesson International Holdings LLC	  	McKesson Transportation Systems, Inc.
		
	McKesson International Holdings S.a.r.l.	  	McKesson UK Holdings Limited
		
	McKesson International Holdings SRL	  	McQueary Bros. Drug Company, LLC
		
	McKesson International Holdings V S.a.r.l.	  	Medcon Systems (1993)
		
	McKesson International Holdings VII S.a.r.l.	  	Medcon UK Limited
		
	McKesson International Malaysia Sdn Bhd	  	Medical & Vaccine Products, Inc.
		
	McKesson International Netherlands BV	  	MHD-USO General, LLC
		
	McKesson International Netherlands II B.V.	  	Moore Medical LLC
		
	McKesson International S.a.r.l.	  	MSA Products LLC
		
	McKesson International SRL	  	N.V Medicopharma
		
	McKesson International Sweden I AB	  	National Oncology Alliance, Inc.
		
	McKesson International Sweden II AB	  	NDCHealth Corporation
		
	McKesson International Sweden III AB	  	NDCHealth Pharmacy Systems and Services, Inc.
		
	McKesson International Topholdings S.a.r.l.	  	Nebraska Pharmaceutical Services, LLC
		
	McKesson Ireland	  	New Mexico Pharmaceutical Services, LLC
		
	McKesson Israel Ltd.	  	NexCura, LLC
		
	McKesson Medical Imaging Company	  	North Carolina Pharmaceutical Services, LLC
		
	McKesson Medical-Surgical FDT Inc.	  	Northstar Healthcare
		
	McKesson Medical-Surgical Holdings Inc.	  	Northstar Healthcare Holdings
		
	McKesson Medical-Surgical Inc.	  	Northstar Healthcare Singapore Pte. Ltd
		
	McKesson Medical-Surgical International	  	Northstar Rx LLC
		
	McKesson Medical-Surgical MediMart Inc.	  	Oncology Holdings II, Inc.

  
 Schedule 5.11-2 

			
	Oncology Holdings, Inc.	  	St. Louis Pharmaceutical Services, LLC
		
	Oncology Rx Care Advantage, LP	  	Sterling Medical Services, LLC
		
	Oncology Therapeutics Network Corporation	  	Strategic Health Alliance II, Inc.
		
	Oncology Today, LP	  	Strategic Health Alliance Management Corp.
		
	Onmark, Inc.	  	System C Healthcare plc
		
	OTN Generics, Inc.	  	Texas Pharmaceutical Services, LLC
		
	OTN Participant, Inc.	  	The Oncology Portal, LLC
		
	Per-Se Technologies Canada, Inc.	  	The Oregon Cancer Centers, Ltd.
		
	Perigon Ltd.	  	TOPS Pharmacy Services, Inc.
		
	Pharmessor Group Corporation	  	Unity Oncology, LLC
		
	Physician Reliance Network, LLC	  	US Oncology Clinical Development, LLC
		
	Physician Reliance, LLC	  	US Oncology Corporate, Inc.
		
	Physician Reliance Maryland, LP	  	US Oncology Holdings, Inc.
		
	Portico Systems of Delaware, Inc.	  	US Oncology Integrated Solutions, LP
		
	PST Services, Inc.	  	US Oncology Lab Services, LLC
		
	Purchasing Alliance for Clinical Therapeutics,	  	US Oncology Pharmaceutical Services, LLC
		
	LLC	  	US Oncology Reimbursement Solutions, LLC
		
	RFCC Asset, LLC	  	US Oncology Research, LLC
		
	RMCC Cancer Center, LLC	  	US Oncology Specialty, LP
		
	S.K.U., Inc.	  	US Oncology, Inc.
		
	SelectPlus Oncology, LLC	  	WFCC Radiation Management Company, LLC
		
	SIVEM Pharmaceuticals ULC	  	Zee Medical Canada Corporation
		
	Southeast Texas Cancer Centers, LP	  	Zee Medical, Inc.

  
 Schedule 5.11-3 

 SCHEDULE 5.12 

MATERIAL SECURED INDEBTEDNESS 

Indebtedness of CGSF Funding Corporation, a Delaware corporation (“CGSF”), under the “Transaction Documents” as defined in
that certain Fourth Amended and Restated Receivables Purchase Agreement dated as of May 18, 2011 among CGSF, as seller, the Company, as initial servicer, the conduit purchasers, committed purchasers and managing agents from time to time party
thereto and JPMorgan Chase Bank, N.A., as collateral agent. 

  
 Schedule 5.12-1 

 SCHEDULE 11.02 

ADMINISTRATIVE AGENT’S OFFICE, 

CERTAIN ADDRESSES FOR NOTICES 
 COMPANY:

 McKesson Corporation 
 One Post Street 

San Francisco, CA 94104-5296 
 Attention: Nicholas A. Loiacono,
Vice President and Treasurer 
 Telephone: (415) 
 Facsimile:
(415) 983-8826 
 Electronic mail: 
 Website
address: www.mckesson.com  
 McKESSON CANADA: 

McKesson Canada Corporation 
 8625 Trans Canada Highway 

St. Laurent, Quebec 
 Canada H4Z 1Z6 

Attention: Paula Keays, Chief Financial Officer 
 Telephone: (514)

 Facsimile: (514) 832-8232 
 Electronic mail: 

Website address: www.mckesson.ca 
 with a copy of all notices
to: 
 Nicholas A. Loiacono, Vice President and Treasurer, McKesson Corporation (see Company contact information above) 

ADMINISTRATIVE AGENT: 
 Administrative Agent’s
Contact for Payments and Requests for Credit Extensions:  
 Bank of America, N.A. 

2001 Clayton Road 
 Mail Code: CA4-702-02-25 

Concord, CA 94520-2405 
 Attention: Anthony Salvador 

Telephone: (925) 675-8101 
 Facsimile: 415-249-5033 

Electronic Mail: Anthony.salvador@baml.com  

Payment Instructions:  
 Bank of America, N.A. 

  
 Schedule 11.02-1 

 New York, NY 
 Attn:
Credit Services West 
 ABA #: 
 Account #: 

Ref: McKesson Corporation 
 Other Notices as Administrative
Agent:  
 Bank of America, N.A. 
 Agency Management

 1455 Market Street 
 Mail Code: CA5-701-05-19 

San Francisco, CA 94103 
 Attention: Kevin Ahart 

Telephone: (415) 436-2750 
 Facsimile: (415) 503-5000

 Electronic Mail: kevin.ahart@baml.com  
 CANADIAN
ADMINISTRATIVE AGENT: 
 Canadian Administrative Agent’s Office:  

Bank of America, N.A., Canada Branch 
 181 Bay Street, 4th Floor 
 Toronto, Ontario M5J 2V8 

Contact for Payments and Requests for Credit Extensions:  

Attn: Clara McGibbon 
 Telephone: (416) 369-2838 

Facsimile: (416) 369-7647 
 Attn: Dita Kumudewati 

Telephone: (416) 349-2845 
 Facsimile: (416) 369-7647

 Other Notices as Canadian Administrative Agent:  

Attn: Medina Sales de Andrade, VP 
 Telephone: (416) 369-2574

 Facsimile: (416) 369-7647 
 Payment Instructions:
 
 Canadian Dollar 
 LVTS — Large Value
Transaction System 
 Bank of America, N.A., Canada Branch 
 200
Front Street West, Toronto 
 Attn: Agency Loans Admin. 
 Swift
Code: BOFACATT 

  
 Schedule 11.02-2 

 Transit #: 
 Account
#: 
 Ref: McKesson Canada 
 L/C ISSUER: 

Wells Fargo Bank, National Association 
 Address: 7711
Plantation Rd, Roanoke, VA 24019 
 Attention: Commercial Loan Services 

Telephone: 866-647-7249 
 Facsimile: 704-715-0099 

Electronic Mail: specializedloans@wachovia.com  
 with
a copy of all notices to: 
 Address: 301 South College Street, 15th Floor Charlotte NC 28202 

Attention: Kirk Tesch 
 Telephone: 704-715-1708 

Facsimile: 704-715-1438 
 Electronic Mail:
kirk.tesch@wellsfargo.com  

  
 Schedule 11.02-3 

 EXHIBIT A 

FORM OF COMMITTED LOAN NOTICE 

Date: [            ] 

 

			
	To:	  	Bank of America, N.A., as Administrative Agent
		
		  	[Bank of America, N.A. (acting through its Canada branch), Canadian Administrative Agent ]
		
		  	Ladies and Gentlemen:

 Reference is made to that certain Credit Agreement, dated as of September 23, 2011 (as amended, restated,
extended, supplemented or otherwise modified in writing from time to time, the “Agreement”; the terms defined therein being used herein as therein defined), among McKesson Corporation, a Delaware corporation, McKesson Canada
Corporation, a Nova Scotia unlimited company, each other Domestic Borrower party thereto, the Lenders from time to time party thereto, Bank of America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A.,
as Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer. 
 The undersigned hereby requests (select one): 

 

	  ̈ A Borrowing of Committed Loaans 
	 ̈ A conversion of Loans 

 ̈ A continuation of Loans 

1. The Borrower is                     .

 2. On         (a Business Day). 

3. In the amount of                     .

 4. Comprised of [Eurodollar Rate Loans] [Base Rate Loans][Canadian Prime Rate Loans]. [Type of Committed Loan requested ] 

5. For Eurodollar Rate Loans: with an Interest Period of             months. 

6. The Applicable Currency is [Dollars] [Canadian Dollars] 

[The Borrowing requested herein complies with the proviso to the first sentence of Section 2.01(a) of the Agreement and, if
made with respect to Canadian Loans, Section 2.01(b)(i) of the Agreement. ]  
  

			
	 [BORROWER]

		
	 By:
	 	  

		 	Name:
		 	Title:

  
 Exhibit A-1 

 EXHIBIT B-1 

FORM OF NOTE 
 [DOMESTIC
LOANS] 
 FOR VALUE RECEIVED, the undersigned [McKesson Corporation, a Delaware corporation] (the “Borrower”), hereby
promises to pay to [            ] or registered assigns (the “Lender”), in accordance with the provisions of the Agreement (as hereinafter defined), the principal amount of
each Loan from time to time made by the Lender to the Borrower under that certain Credit Agreement, dated as of September 23, 2011 (as amended, restated, extended, supplemented or otherwise modified in writing from time to time, the
“Agreement”; the terms defined therein being used herein as therein defined), among the Borrower, McKesson Canada Corporation, each other Domestic Borrower party thereto, the Lenders from time to time party thereto, Bank of America,
N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A., as Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer. 

The Borrower promises to pay interest on the unpaid principal amount of each Loan from the date of such Loan until such principal amount is
paid in full, at such interest rates and at such times as provided in the Agreement. All payments of principal and interest shall be made to the Administrative Agent for the account of the Lender in Dollars in immediately available funds at the
Administrative Agent’s Office. If any amount is not paid in full when due hereunder, such unpaid amount shall bear interest, to be paid upon demand, from the due date thereof until the date of actual payment (and before as well as after
judgment) computed at the per annum rate set forth in the Agreement. 
 This Note is one of the Notes referred to in the Agreement, is
entitled to the benefits thereof and may be prepaid in whole or in part subject to the terms and conditions provided therein. Upon the occurrence and continuation of one or more of the Events of Default specified in the Agreement, all amounts then
remaining unpaid on this Note shall become, or may be declared to be, immediately due and payable all as provided in the Agreement. Loans made by the Lender shall be evidenced by one or more loan accounts or records maintained by the Lender in the
ordinary course of business. The Lender may also attach Schedules to this Note and endorse thereon the date, amount and maturity of its Loans and payments with respect thereto. 

The Borrower, for itself, its successors and assigns, hereby waives diligence, presentment, protest and demand and notice of protest, demand,
dishonor and non-payment of this Note. 
 THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

  

			
	[MCKESSON CORPORATION]
		
	By:	 	  

		 	Name:
		 	Title:

  
 Exhibit B-1-1 

 EXHIBIT B-2 

FORM OF NOTE 
 [CANADIAN
LOANS] 
 FOR VALUE RECEIVED, the undersigned, McKesson Canada Corporation, a Nova Scotia unlimited company (the
“Borrower”), hereby promises to pay to [            ] or registered assigns (the “Lender”), in accordance with the provisions of the Agreement (as
hereinafter defined), the principal amount of each Loan from time to time made by the Lender to the Borrower under that certain Credit Agreement, dated as of September 23, 2011 (as amended, restated, extended, supplemented or otherwise modified
in writing from time to time, the “Agreement”; the terms defined therein being used herein as therein defined), among the Borrower, McKesson Corporation, each other Domestic Borrower party thereto, the Lenders from time to time
party thereto, Bank of America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A., as Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer. 

The Borrower promises to pay interest on the unpaid principal amount of each Loan from the date of such Loan until such principal amount is
paid in full, at such interest rates and at such times as provided in the Agreement. All payments of principal and interest shall be made to the Canadian Administrative Agent for the account of the Lender in Canadian Dollars in immediately available
funds at the Canadian Administrative Agent’s Office. If any amount is not paid in full when due hereunder, such unpaid amount shall bear interest, to be paid upon demand, from the due date thereof until the date of actual payment (and before as
well as after judgment) computed at the per annum rate set forth in the Agreement. 
 This Note is one of the Notes referred to in the
Agreement, is entitled to the benefits thereof and may be prepaid in whole or in part subject to the terms and conditions provided therein. Upon the occurrence and continuation of one or more of the Events of Default specified in the Agreement, all
amounts then remaining unpaid on this Note shall become, or may be declared to be, immediately due and payable all as provided in the Agreement. Loans made by the Lender shall be evidenced by one or more loan accounts or records maintained by the
Lender in the ordinary course of business. The Lender may also attach Schedules to this Note and endorse thereon the date, amount and maturity of its Loans and payments with respect thereto. 

The Borrower, for itself, its successors and assigns, hereby waives diligence, presentment, protest and demand and notice of protest, demand,
dishonor and non-payment of this Note. 
 THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

  

			
	MCKESSON CANADA CORPORATION
		
	 By:
	 	  

		 	Name:
		 	Title:

  
 Exhibit B-2-1 

 LOANS AND PAYMENTS WITH RESPECT THERETO 

 

													
	Date	 	 Type of

Loan Made
	 	 Amount of

Loan Made
	  	 End of

Interest

Period
	  	 Amount of

Principal or
 Interest
Paid
 This Date
	  	 Outstanding
Principal

Balance
 This
Date
	  	 Notation

Made By

		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	
		 		 		  		  		  		  	

  
 Exhibit B-2-2 

 EXHIBIT C 

FORM OF COMPLIANCE CERTIFICATE 

Financial Statement Date:
                    , 
  

			
	To:	  	Bank of America, N.A., as Administrative Agent
		
		  	Ladies and Gentlemen:

 Reference is made to that certain Credit Agreement dated as of September 23, 2011 (as amended, restated,
extended, supplemented or otherwise modified in writing from time to time, the “Agreement”; the terms defined therein being used herein as therein defined), among McKesson Corporation, a Delaware corporation (the
“Company”), McKesson Canada Corporation, a Nova Scotia unlimited company, each other Domestic Borrower party thereto, the Lenders from time to time party thereto, Bank of America, N.A. (acting through its Canada branch), as Canadian
Administrative Agent, Bank of America, N.A., as Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer. 
 The
undersigned Responsible Officer hereby certifies as of the date hereof that he/she is the of the Company, and that, as such, he/she is authorized to execute and deliver this Certificate to the Administrative Agent on the behalf of the Company, and
that: 
 [Use following paragraph 1 for fiscal year-end financial statements]  

 

	 	1.	Attached hereto as Schedule 1 are the year-end audited financial statements required by Section 6.01(a) of the Agreement for the fiscal year of the Company ended as of the above date, together with the
report and opinion of an independent certified public accountant required by such Section. 

 [Use following
paragraph 1 for fiscal quarter-end financial statements]  
 1. Attached hereto as Schedule 1 are the
unaudited financial statements required by Section 6.01(b) of the Agreement for the fiscal quarter of the Company ended as of the above date. Such financial statements fairly present the financial condition, results of operations and
cash flows of the Company and its Subsidiaries in accordance with GAAP as at such date and for such period, subject only to normal year-end audit adjustments and the absence of footnotes. 

2. The undersigned has reviewed and is familiar with the terms of the Agreement and has made, or has caused to be made under his/her
supervision, a detailed review of the transactions and condition (financial or otherwise) of the Company during the accounting period covered by the attached financial statements. 

3. A review of the activities of the Company during such fiscal period has been made under the supervision of the undersigned with a view to
determining whether during such fiscal period the Company performed and observed all its Obligations under the Loan Documents, and 

[select one:] 
 [to the
best knowledge of the undersigned during such fiscal period, the Company performed and observed each covenant and condition of the Loan Documents applicable to it.] 

  
 Exhibit C-1 

 [the following covenants or conditions have not been performed or observed and the following is a
list of each such Default and its nature and status: 
  

	
	
                    
                                         
                                         
                                         
                        

	
	
                    
                                         
                                         
                                         
                        

	
	                                      
                                         
                                         
                                         
     ]

 4. The representations and warranties of the Company contained in Article V of the Agreement, or which
are contained in any document furnished at any time under or in connection with the Loan Documents, are true and correct on and as of the date hereof, except to the extent that such representations and warranties specifically refer to an earlier
date, in which case they are true and correct as of such earlier date, and except for purposes of this Compliance Certificate, the representations and warranties contained in Section 5.08(a) of the Agreement shall be deemed to refer to
the most recent statements furnished pursuant to clauses (a) and (b) respectively, of Section 6.01 of the Agreement, including the statements in connection with which the Compliance Certificate is delivered. 

5. The financial covenant analyses and information set forth on Schedule 1 attached hereto are true and accurate on and as of the date
of this Certificate. 

  
 Exhibit C-2 

 IN WITNESS WHEREOF, the undersigned has executed this Certificate as of
            ,             . 
  

			
	MCKESSON CORPORATION
		
	By:	 	  

		 	Name:
		 	Title:

  
 Exhibit C-3 

 For the Quarter/Year ended         (“Statement Date”)

 SCHEDULE 1 
 to the
Compliance Certificate 
  

							
	 	  	 Maximum Total Debt to Capitalization Ratio
	  	($ in 000’s)	 
	1.    	  	Total Debt:	  	$	 	 
			
	2.	  	Net Worth (sum of Items 2(a), 2(b), 2(c) and 2(d), minus Item 2(e) below):	  	$	 	 
			
		  	(a) Capital stock:	  	$	 	 
			
		  	(b) Additional paid-in-capital:	  	$	 	 
			
		  	(c) Retained earnings (accumulated deficits):	  	$	 	 
			
		  	(d) Accumulated other comprehensive income:	  	$	 	 
			
		  	(e) Treasury stock	  	$	 	 
			
	3.	  	Total Capitalization (sum of Items 1 and 2):	  	$	 	 
			
	4.	  	Ratio of Total Debt (Item 1) to Total Capitalization (Item 3):	  	 	 :      	 
			
	5.	  	Maximum Ratio Permitted under Section 7.04:	  	 	0.565:1.00	  

  
 Exhibit C-4 

 EXHIBIT D 

FORM OF ASSIGNMENT AND ASSUMPTION 

This Assignment and Assumption (this “Assignment and Assumption”) is dated as of the Effective Date set forth below and is
entered into by and between [ Insert name of Assignor ] (the “Assignor”) and [ Insert name of Assignee ] (the “Assignee”). Capitalized terms used but not defined herein
shall have the meanings given to them in the Credit Agreement identified below (the “Credit Agreement”), receipt of a copy of which is hereby acknowledged by the Assignee. The Standard Terms and Conditions set forth in Annex 1
attached hereto are hereby agreed to and incorporated herein by reference and made a part of this Assignment and Assumption as if set forth herein in full. 

For an agreed consideration, the Assignor hereby irrevocably sells and assigns to the Assignee, and the Assignee hereby irrevocably purchases
and assumes from the Assignor, subject to and in accordance with the Standard Terms and Conditions and the Credit Agreement, as of the Effective Date inserted by the Administrative Agent as contemplated below (i) all of the Assignor’s
rights and obligations as a Lender under the Credit Agreement and any other documents or instruments delivered pursuant thereto to the extent related to the amount and percentage interest identified below of all of such outstanding rights and
obligations of the Assignor under the respective facilities identified below (including Letters of Credit included in such facilities) and (ii) to the extent permitted to be assigned under applicable law, all claims, suits, causes of action and
any other right of the Assignor (in its capacity as a Lender) against any Person, whether known or unknown, arising under or in connection with the Credit Agreement, any other documents or instruments delivered pursuant thereto or the loan
transactions governed thereby or in any way based on or related to any of the foregoing, including, but not limited to, contract claims, tort claims, malpractice claims, statutory claims and all other claims at law or in equity related to the rights
and obligations sold and assigned by the Assignor to the Assignee pursuant to clause (i) above (the rights and obligations sold and assigned pursuant to clauses (i) and (ii) above being referred to herein collectively as, the
“Assigned Interest”). Such sale and assignment is without recourse to the Assignor and, except as expressly provided in this Assignment and Assumption, without representation or warranty by the Assignor. 

 

					
	1.	  	Assignor:	  	
			
	2.	  	Assignee:	  	            [and is an Affiliate/Approved Fund of [identify Lender]]
			
	3.    	  	Borrower(s):	  	McKesson Corporation and McKesson Canada Corporation and [        ]
			
	4.	  	Administrative Agent	  	Bank of America, N.A., as the administrative agent under the Credit Agreement
			
	5.	  	Credit Agreement:	  	The Credit Agreement, dated as of September 23, 2011, among McKesson Corporation, McKesson Canada Corporation, each other Domestic Borrower party thereto, the Lenders from time to time party thereto, Bank of America, N.A., as
Administrative Agent, Bank of America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer

  
 Exhibit D-1 

	6.	Assigned Interest: 

  

															
	 Facility
 Assigned
	  	 Aggregate

amount of
 Commitment

for all Lenders*
	 	  	 Amount of

Commitment
 Assigned*
	 	 	 Percentage

Assigned of
 Commitment1
	 	 	 CUSIP

Number

	 Domestic Loans
	  	$	            	 	  	$	            	 	 	 	[    .        	]% 	 	
					
	 Canadian Loans
	  	$	 	 	  	$	 	 	 	 	[    .        	]% 	 	
					
		  	$	 	 	  	$	 	 	 	 	[    .        	]% 	 	
					
	 7.      Trade Date:
	  				  	 	2	  	 				 	

 Effective Date:         , 20    [TO BE INSERTED BY
ADMINISTRATIVE AGENT AND WHICH SHALL BE THE EFFECTIVE DATE OF RECORDATION OF TRANSFER IN THE REGISTER THEREFOR.] 
 The terms set forth in
this Assignment and Assumption are hereby agreed to: 
 ASSIGNOR 

[NAME OF ASSIGNOR] 
  

			
	By:	 	  

		 	Name:
		 	Title:

 ASSIGNEE 
 [NAME OF
ASSIGNEE] 
  

			
	By:	 	  

		 	Name:
		 	Title:
		
		 	 [Consented to and] Accepted:
 Bank of
America, N.A., as Administrative Agent

  

			
	 By:
	 	  

		 	Name:
		 	Title:

  

	1 	Set forth, to at least 9 decimals, as a percentage of the Commitment of all Lenders thereunder. 

	2 	To be completed if the Assignor and the Assignee intend that the minimum assignment amount is to be determined as of the Trade Date. 

  
 Exhibit D-2 

			
	 [Consented to:
 MCKESSON
CORPORATION

		
	By:	 	  

		 	Name:
		 	Title:]

  
 Exhibit D-3 

 ANNEX 1 TO ASSIGNMENT AND ASSUMPTION 

CREDIT AGREEMENT 
 DATED AS OF
SEPTEMBER 23, 2011 
 MCKESSON CORPORATION, MCKESSON CANADA CORPORATION, EACH OTHER 

DOMESTIC BORROWER PARTY THERETO, 

THE LENDERS PARTY THERETO, BANK OF AMERICA, N.A. (ACTING THROUGH ITS 

CANADA BRANCH, AS CANADIAN 

ADMINISTRATIVE AGENT, BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT, AND WELLS FARGO BANK, NATIONAL ASSOCIATION, AS L/C ISSUER 

STANDARD TERMS AND CONDITIONS FOR 

ASSIGNMENT AND ASSUMPTION 
 1.
Representations and Warranties. 
 1.1. Assignor. The Assignor (a) represents and warrants that (i) it is the legal
and beneficial owner of the Assigned Interest, (ii) the Assigned Interest is free and clear of any lien, encumbrance or other adverse claim and (iii) it has full power and authority, and has taken all action necessary, to execute and
deliver this Assignment and Assumption and to consummate the transactions contemplated hereby; and (b) assumes no responsibility with respect to (i) any statements, warranties or representations made in or in connection with the Credit
Agreement or any other Loan Document, (ii) the execution, legality, validity, enforceability, genuineness, sufficiency or value of the Loan Documents or any collateral thereunder, (iii) the financial condition of the Company, any of its
Subsidiaries or Affiliates or any other Person obligated in respect of any Loan Document or (iv) the performance or observance by the Company, any of its Subsidiaries or Affiliates or any other Person of any of their respective obligations
under any Loan Document. 
 1.2. Assignee. The Assignee (a) represents and warrants that (i) it has full power and
authority, and has taken all action necessary, to execute and deliver this Assignment and Assumption and to consummate the transactions contemplated hereby and to become a Lender under the Credit Agreement, (ii) it meets all requirements of an
Eligible Assignee under the Credit Agreement (subject to receipt of such consents as may be required under the Credit Agreement), (iii) from and after the Effective Date, it shall be bound by the provisions of the Credit Agreement as a Lender
thereunder and, to the extent of the Assigned Interest, shall have the obligations of a Lender thereunder, (iv) it has received a copy of the Credit Agreement, together with copies of the most recent financial statements delivered pursuant to
Section 6.01 thereof, as applicable, and such other documents and information as it has deemed appropriate to make its own credit analysis and decision to enter into this Assignment and Assumption and to purchase the Assigned Interest on the
basis of which it has made such analysis and decision independently and without reliance on the Administrative Agent or any other Lender, and (v) if it is a Foreign Lender, attached hereto is any documentation required to be delivered by it
pursuant to the terms of the Credit Agreement, duly completed and executed by the Assignee; and (b) agrees that (i) it will, independently and without reliance on the Administrative Agent, the Assignor or any other Lender, and based on
such documents and information as it shall deem appropriate at the time, continue to make its own credit decisions in taking or not taking action under the Loan Documents, and (ii) it will perform in accordance with their terms all of the
obligations which by the terms of the Loan Documents are required to be performed by it as a Lender. 

  
 Exhibit D-4 

 2. Payments. From and after the Effective Date, the Administrative Agent shall make all
payments in respect of the Assigned Interest (including payments of principal, interest, fees and other amounts) to the Assignor for amounts which have accrued to but excluding the Effective Date and to the Assignee for amounts which have accrued
from and after the Effective Date. 
 3. General Provisions. This Assignment and Assumption shall be binding upon, and inure to the
benefit of, the parties hereto and their respective successors and assigns. This Assignment and Assumption may be executed in any number of counterparts, which together shall constitute one instrument. Delivery of an executed counterpart of a
signature page of this Assignment and Assumption by telecopy shall be effective as delivery of a manually executed counterpart of this Assignment and Assumption. This Assignment and Assumption shall be governed by, and construed in accordance with,
the law of the State of New York. 

  
 Exhibit D-5 

 EXHIBIT E 

FORM OF DRAWING NOTICE 

Pursuant to that certain Credit Agreement, dated as of September 23, 2011 (as amended, restated, extended, supplemented or otherwise
modified in writing from time to time, the “Agreement”; the terms defined therein being used herein as therein defined), among McKesson Corporation, a Delaware corporation, McKesson Canada Corporation, a Nova Scotia unlimited
company, each other Domestic Borrower party thereto, the Lenders from time to time party thereto (the “Lenders”), Bank of America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A., as
Administrative Agent and Wells Fargo Bank, National Association, as L/C Issuer, this represents McKesson Canada’s notice pursuant to Section 2.04(b) of the Agreement that McKesson Canada hereby requests a Drawing under the
Agreement, and, in connection therewith, sets forth below the information relating to such Drawing as required by Section 2.04(b) of the Agreement: 

1. The Drawing Date, which is a Business Day, is             ; 

2. The aggregate Face Amount of Drafts to be accepted is Cdn.$             ; 

3. The maturity date for such Drafts is             ,
            , which represents a term to maturity of approximately [ Insert term of bill of exchange, which may be anywhere from 7 to 180 ] days. 

 

							
	Dated:	 		 	MCKESSON CANADA CORPORATION
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  
 Exhibit E-1 

 EXHIBIT F 

FORM OF JOINDER AGREEMENT 

This JOINDER AGREEMENT, dated as of [            ] (this “Joinder
Agreement”), is entered into among McKesson Corporation, a Delaware corporation (the “Company”), [INSERT NAME OF DOMESTIC SUBSIDIARY BORROWER], a [INSERT JURISDICTION AND TYPE OF ORGANIZATION OF DOMESTIC SUBSIDIARY
BORROWER] (the “Additional Borrower”), and Bank of America, N.A., in its capacity as Administrative Agent (in such capacity, the “Administrative Agent”), under and as defined in the Agreement referred to below. 

RECITALS 
 A. The Company,
McKesson Canada Corporation, a Nova Scotia unlimited company (“McKesson Canada”), and each other Domestic Borrower party thereto have entered into that certain Credit Agreement, dated as of September 23, 2011 (as amended,
restated, extended, supplemented or otherwise modified in writing from time to time, the “Agreement”; the terms defined therein being used herein as therein defined), with the Lenders from time to time party thereto, Bank of
America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A., as Administrative Agent, and Wells Fargo Bank, National Association, as L/C Issuer, pursuant to which the Lenders and the L/C Issuer have
agreed to make certain Credit Extensions to the Borrowers on behalf and for the benefit of the Borrowers on the terms and subject to the conditions set forth therein and the other Loan Documents. 

B. The Additional Borrower is a wholly owned [in]direct Domestic Subsidiary of the Company that wishes to become a Borrower party to the
Agreement, entitled to receive Credit Extensions thereunder. 
 C. Pursuant to Section 7.02(d) of the Agreement, the Company has
requested that the Additional Borrower become a Borrower party to the Agreement, entitled to receive Credit Extensions thereunder, and the Agents, Lenders and L/C Issuer have agreed to such request. 

AGREEMENT 
 1. 7.02(d)
Domestic Subsidiary. By executing and delivering this Joinder Agreement, the Company hereby represents and warrants that Additional Borrower is a wholly-owned [in]direct Domestic Subsidiary of the Company that, concurrent herewith, is receiving
a transfer of all of the Company’s pharmacology distribution business. 
 2. Joined as Borrower Under Agreement. By executing
and delivering this Joinder Agreement as provided in Section 7.02(d) of the Agreement, the Additional Borrower hereby becomes a party to the Agreement as a Borrower thereunder with the same force and effect as if originally named therein
as a Borrower and, without limiting the generality of the foregoing, hereby expressly and unconditionally assumes all obligations and liabilities of a Borrower thereunder. The Additional Borrower hereby irrevocably appoints the Company as its agent
for all purposes relevant to the Agreement and each of the other Loan Documents, including (i) the giving and receipt of notices, (ii) the execution and delivery of all documents, instruments and certificates contemplated in the Agreement
and all modifications thereto, and (iii) the receipt of the proceeds of any Loans made by the Lenders to any such Additional Borrower. Any acknowledgment, consent, direction, certification or other action which might otherwise be valid or
effective only if given or taken by all Borrowers, or by each Borrower acting singly, shall be valid and effective if given or taken only by the Company, whether or not any such other Borrower joins therein. Any notice, demand, consent,
acknowledgement, direction, certification or other communication delivered to the Company in accordance with the terms of this Agreement shall be deemed to have been delivered to such Additional Borrower. 

  
 Exhibit F-1 

 3. Supplement to Schedules; Representations and Warranties. The information set forth in
Annex I to this Joinder Agreement is hereby added to the information set forth in the schedules to the Agreement. The Additional Borrower hereby represents and warrants that each of the representations and warranties contained in Article
V of the Agreement, with respect to itself, is true and correct on and as the date hereof (after giving effect to this Joinder Agreement) as if made on and as of such date. 

4. Governing Law. This Joinder Agreement shall be governed by, and construed in accordance with, the law of the State of New York
applicable to agreements made and to be performed entirely within such State; provided that the Agents, the L/C Issuer and each Lender shall retain all rights arising under Federal law. 

IN WITNESS WHEREOF, the undersigned has caused this Joinder Agreement to be duly executed and delivered as of the date first above written.

  

			
	 MCKESSON CORPORATION

		
	 By
	 	  

		 	Name:
		 	Title:
	
	 [INSERT NAME OF DOMESTIC

SUBSIDIARY BORROWER]

		
	By	 	  

		 	Name:
		 	Title:

  

			
	 Accepted:

	  
 BANK OF
AMERICA, N.A., as
 Administrative Agent

		
	By:	 	  

		 	Name:
		 	Title:

  
 Exhibit F-2 

 Annex I-A 

to Joinder Agreement 

SUPPLEMENT TO AGREEMENT SCHEDULES 

  
 Exhibit F-3 

 EXHIBIT G 

FORM OF DOMESTIC BORROWER NOTICE 

Date:                    
,             
  

			
	To:	  	McKesson Corporation
		
		  	The Lenders party to the Agreement referred to below

 Ladies and Gentlemen: 

This Domestic Borrower Notice is made and delivered pursuant to Section 7.02(d) of that certain Credit Agreement, dated as of
September 23, 2011 (as amended, restated, extended, supplemented or otherwise modified in writing from time to time, the “Agreement”), among McKesson Corporation (the “Company”), McKesson Canada Corporation,
each other Domestic Borrower party thereto, the Lenders from time to time party thereto, Bank of America, N.A. (acting through its Canada branch), as Canadian Administrative Agent, Bank of America, N.A., as Administrative Agent, and Wells Fargo
Bank, National Association, as L/C Issuer, and reference is made thereto for full particulars of the matters described therein. All capitalized terms used in this Domestic Borrower Notice and not otherwise defined herein shall have the meanings
assigned to them in the Agreement. 
 The Administrative Agent hereby notifies Company and the Lenders that effective as of the date hereof
[            ] shall be a Domestic Borrower and may receive Loans for its account on the terms and conditions set forth in the Agreement. 

This Domestic Borrower Notice shall constitute a Loan Document under the Agreement. 

 

			
	 BANK OF AMERICA, N.A.,
 as
Administrative Agent

		
	 By:
	 	  

	 Title:
	 	

  
 Exhibit G-1

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