Document:

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                                                                   EXHIBIT 10.12

[COLORADO BUSINESS LEASING, INC. LETTERHEAD]

NOTE NO.: 9000228-001

$280,000.00                                               DATE: November 1, 2000

For value received, the undersigned and each thereof, promises to pay to
COLORADO BUSINESS LEASING, INC. or its order, at said company in Denver,
Colorado, TWO HUNDRED EIGHTY THOUSAND DOLLARS and NO CENTS with interest thereon
from the date hereof until maturity at a rate of 10.75 PERCENT, and after
maturity at the prime rate plus FIVE PERCENT. The makers and endorsers hereof,
and all persons who are or may become parties to this instrument, hereby waive
presentment for payment, protest, notice of nonpayment and of protest, and agree
to any extensions of time of payment and partial payments before, at, or after
maturity, to the addition or release of any party or person primarily or
secondarily liable, to the release or substitution of any or all collateral and
to any other indulgence granted by the holder to any party liable thereon.

The principal of this note is repayable as follows:

THIRTY-SIX monthly payments at $9,052.63 principal and interest beginning
NOVEMBER 1, 2000 and on the FIRST day of each month thereafter. The entire
balance shall be due on or before OCTOBER 1, 2003. If a payment is 10 DAYS OR
MORE LATE, Borrower will be charged an additional amount equal to 5% of the
payment.

Maturity of all principal and interest due hereunder shall at the option of the
holder be accelerated and such principal and interest be immediately due and
payable at the option of the holder without notice or demand upon the occurrence
of any of the following events of default: (a) Failure to pay when due any
installment of principal or interest; (b) default in the performance of any
other liability or undertaking to the holder of any maker, endorser or guarantor
hereof; including violation of the financial covenants noted below; (c) when the
holder hereof in good faith deems itself insecure or feels that the prospect of
payment of this note is impaired; (d) death, dissolution, insolvency (or the
occurrence of anything in the opinion of the holder evidencing insolvency),
termination of existence of, or the commencement of any proceedings under any
bankruptcy or insolvency laws by or against, any maker, endorser or guarantor
hereof. The undersigned will pay on demand all costs of collection of the
indebtedness due hereunder, including reasonable attorneys' fees, paid or
incurred by the holder, and the same shall constitute a part of the indebtedness
represented hereby and be secured by any and ail collateral securing this
promissory note.

Any deposits or other sums credited by or due from the holder to any maker,
endorser or guarantor hereof and any property of any maker, endorser or
guarantor in the holder's possession may at all times be held and treated as
collateral security for the payment hereof, and the holder may set off or apply
the same against any matured liability hereunder at any time.

No failure to exercise or delay in exercising any right hereunder of the holder
shall operate as a waiver of such right or of any other right hereunder, nor
shall any waiver by the holder be construed as a waiver of such right on any
future occasion. If executed by more than one maker, the obligation represented
hereby shall be joint and several. After default the holder may apply payment on
account hereof, however designated, to principal or interest in the holder's
discretion.

DURING THE TERM OF THIS PROMISSORY NOTE, OBLIGOR WILL MAINTAIN THE FOLLOWING
         FINANCIAL COVENANTS:
         MAINTAIN MINIMUM NET WORTH INCLUDING SUBORDINATED DEBT NOT LESS THAN
           $750,000.
         MAINTAIN MAXIMUM DEBT EXCLUDING SUBORDINATED TO NET WORTH INCLUDING
           SUBORDINATED OF LESS THAN 1.25:1.
         MAINTAIN CURRENT RATIO GREATER THAN 1.1.
         MAINTAIN MINIMUM TRADITIONAL CASH FLOW COVERAGE OF 5:1.

The laws of the State of Colorado shall govern this Promissory Note.

BORROWER:   AspenBio, Inc.

BY
  --------------------------------
      Roger Hurst, President<PAGE>
                                                                   EXHIBIT 10.13

                                 ASPENBIO, INC.

Number of Shares: 100,000        Date of Grant:                  August 21, 2001

                             STOCK OPTION AGREEMENT

AGREEMENT made this 21st day of August, 2001, between ("Optionee"), and
AspenBio, Inc., a Colorado corporation ("Company").

         1. Grant of Option. The Company, hereby grants to the Optionee, subject
to the terms and conditions set forth or incorporated herein, an Option to
purchase from the Company all or any part of an aggregate of Common Shares, as
such Common Shares are now constituted, at the purchase price of $1.00 per
share.

         2. Exercise. The Option evidenced hereby shall be exercisable in whole
or in part (but only in multiples of 10,000 Shares unless such exercise is as to
the remaining balance of this Option) on or after and on or before August 20,
2006, provided that the cumulative number of Common Shares as to which this
Option may be exercised shall not exceed the following amounts:

<Table>
<Caption>
             Cumulative Number                             Prior to Date
                of Shares                               (Not Inclusive of)
          --------------------------                    ------------------
<S>                                                     <C>
                 100,000                                  August 20, 2006
</Table>

The Option evidenced hereby shall be exercisable by the delivery to and receipt
by the Company of (i) a written notice of election to exercise; (ii) accompanied
by payment of the full purchase price thereof in cash or certified check payable
to the order of the Company, and (iii) by return of this Stock Option Agreement
for endorsement of exercise by the Company.

         3. Transferability. The Option evidenced hereby is NOT assignable or
transferable by the Optionee, except with the Company's consent.

AspenBio, Inc.

By:           /s/ Roger Hurst                                8-21-01
     --------------------------------           --------------------------------
     Roger Hurst, President                     Date

Optionee:

             /s/ Gail Schoettler
-------------------------------------           --------------------------------
     Gail Schoettler                            Social Security or Tax ID #

                  8100 Southpark Way, B-1 . Littleton, CO 80120
                       (303) 794-2000 . Fax (303) 798-8332
                               www.aspenbioinc.com<PAGE>
                                                                   EXHIBIT 10.14

                                 ASPENBIO, INC.

Number of Shares: 100,000        Date of Grant:                  August 21, 2001

                             STOCK OPTION AGREEMENT

AGREEMENT made this 21st day of August, 2001, between ("Optionee"), and
AspenBio, Inc., a Colorado corporation ("Company").

         1. Grant of Option. The Company, hereby grants to the Optionee, subject
to the terms and conditions set forth or incorporated herein, an Option to
purchase from the Company all or any part of an aggregate of Common Shares, as
such Common Shares are now constituted, at the purchase price of $1.00 per
share.

         2. Exercise. The Option evidenced hereby shall be exercisable in whole
or in part (but only in multiples of 10,000 Shares unless such exercise is as to
the remaining balance of this Option) on or after and on or before August 20,
2006, provided that the cumulative number of Common Shares as to which this
Option may be exercised shall not exceed the following amounts:

<Table>
<Caption>
                Cumulative Number                         Prior to Date
                    of Shares                           (Not Inclusive of)
                -----------------                       ------------------
<S>                                                     <C>
                    100,000                              August 20, 2006
</Table>

The Option evidenced hereby shall be exercisable by the delivery to and receipt
by the Company of (i) a written notice of election to exercise; (ii) accompanied
by payment of the full purchase price thereof in cash or certified check payable
to the order of the Company, and (iii) by return of this Stock Option Agreement
for endorsement of exercise by the Company.

         3. Transferability. The Option evidenced hereby is NOT assignable or
transferable by the Optionee, except with the Company's consent.

AspenBio, Inc.

By:          /s/ Roger Hurst                               8-21-01
     --------------------------------           --------------------------------
     Roger Hurst, President                     Date

Optionee:

             /s/ Bruce Deal                               ###-##-####
-------------------------------------           --------------------------------
     Bruce Deal                                 Social Security or Tax ID #

                  8100 Southpark Way, B-1 . Littleton, CO 80120
                       (303) 794-2000 . Fax (303) 798-8332
                               www.aspenbioinc.com<PAGE>

                                                                    EXHIBIT 10.4

                      FOUNDER'S STOCK RESTRICTION AGREEMENT

         THIS STOCK RESTRICTION AGREEMENT ("Agreement") is made as of June 1998,
between Novirio Pharmaceuticals Limited, a Cayman Islands corporation (the
"Company"), and Dr. Jean-Pierre Sommadossi ("Consultant").

                                    RECITALS

         In connection with Consultant's services to Novirio Pharmaceuticals,
Inc., a Massachusetts corporation which is a wholly owned subsidiary of the
Company ("Novirio"), pursuant to the Consulting Agreement dated the date hereof
between the Consultant and Novirio (the "Consulting Agreement"), the Company
desires to issue to the Consultant, and the Consultant desires to purchase from
the Company, the Company's Ordinary Shares upon the terms set forth herein.

         NOW, THEREFORE, in consideration of the foregoing premises and the
mutual promises set forth in this Agreement, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties to this Agreement, intending to be legally bound, agree as follows:

                                   SECTION 1

                                   DEFINITIONS

         1.1 Definitions. In addition to the other terms defined in this
Agreement, the terms below shall have the following respective meanings:

                  (a) "Board" means the Board of Directors of the Company.

                  (b) "Majority Stockholders" means, at any time, holders of a
majority of the sum of (i) the outstanding Ordinary Shares and (ii) those shares
of Ordinary Shares into which any Series A Preferred Shares are convertible.

                  (c) "Ordinary Shares" means the Company's Ordinary Shares,
$.001 par value per share.

                  (d) "Person" means an individual, partnership, corporation,
limited liability company, association, trust, joint venture, unincorporated
organization and any government, governmental department or agency or political
subdivision thereof.

                  (e) "Restricted Shares" has the meaning specified in Section
3.1(a).

                  (f) "Sale of the Company" means a single transaction or series
of related transactions, other than a public offering of securities, pursuant to
which a Person or Persons other than existing stockholders of the Company (i)
acquires capital stock of the Company possessing the voting power to elect a
majority of the Board, (ii) consummates a merger, amalgamation or
<PAGE>
consolidation with the Company as a result of which the stockholders of the
Company who own Ordinary Shares or other voting securities prior to such
transaction(s) shall own, directly or indirectly, less than fifty percent (50%)
of the voting securities of the surviving entity or its parent, or (iii)
acquires all or substantially all of the Company's assets (determined on a
consolidated basis with its subsidiaries).

                  (g) "Shares" means the Ordinary Shares issued to the
Consultant pursuant to this Agreement.

                                   SECTION 2

                               PURCHASE OF SHARES

         2.1 Issuance. In consideration of the payment by the Consultant to the
Company of cash in the amount of $.001 per Share concurrently herewith, the
Company hereby issues to the Consultant, and the Consultant hereby accepts from
the Company, 3,000,000 Ordinary Shares (the "Shares") upon the terms and
conditions set forth in this Agreement.

         2.2 Investment Representations.

                  (a) The Consultant hereby represents and warrants that the
Consultant is acquiring the Shares for the Consultant's own account as an
investment only and not with a view toward the sale or distribution thereof in
violation of the United States Securities Act of 1933, as amended (the
"Securities Act"), or any rule or regulation under the Securities Act.

                  (b) The Consultant has had such opportunity as he has deemed
adequate to obtain from representatives of the Company such information as is
necessary to permit him to evaluate the merits and risks of his investment in
the Company.

                  (c) The Consultant has sufficient experience in business,
financial and investment matters to be able to evaluate the risks involved in
the purchase of the Shares and to make an informed investment decision with
respect to such purchase.

                  (d) The Consultant can afford a complete loss of the value of
the Shares and is able to bear the economic risk of holding such Shares for an
indefinite period.

                  (e) The Consultant understands that (i) the Shares have not
been registered under the Securities Act and are "restricted securities" within
the meaning of Rule 144 under the Securities Act, (ii) the Shares cannot be
sold, transferred or otherwise disposed of unless they are subsequently
registered under the Securities Act or an exemption from registration is then
available; (iii) in any event, the exemption from registration under Rule 144
will not be available for at least one (1) year and even then will not be
available unless a public market then exists for the Ordinary Shares, adequate
information concerning the Company is then available to the public, and other
terms and conditions of Rule 144 are complied with; and (iv) there is now no
registration statement on file with the United States Securities and Exchange
Commission with

                                      -2-

<PAGE>
respect to any stock of the Company and the Company has no obligation or current
intention to register the Shares under the Securities Act.

                                   SECTION 3

                                     VESTING

         3.1 Vesting Schedule. The Shares held by the Consultant shall be
subject to vesting as follows:

                  (a) 50% of the Shares (the "Restricted Shares") shall be
subject to vesting with one-fourth of the Restricted Shares to vest on each of
the first four anniversaries of the date hereof so long as the Consulting
Agreement is in effect.

                  (b) Notwithstanding the foregoing, in the event of the closing
of a Sale of the Company at a time when the Consulting Agreement is in effect,
all of the Restricted Shares shall be deemed to have been fully vested
immediately prior to such closing.

         3.2 Forfeiture Upon Failure to Vest. Any Restricted Shares that do not
vest as of the applicable date shall thereupon be deemed for all purposes to
have been forfeited as of such date, and the Consultant shall have no further
rights with respect thereto. In addition, upon Consultant's failure to vest in
any portion of the Restricted Shares, Consultant shall be deemed to have
divested of (i) 25% of the total number of Shares, if such failure to vest
occurs prior to the second anniversary of the date hereof, or (ii) 12.5% of the
total number of Shares, if such failure to vest occurs after the second
anniversary of the date hereof but prior to the fourth anniversary of the date
hereof. All forfeited and divested Shares shall be deemed to have been
transferred to and redeemed by the Company without the need for any payment to
the Consultant or any action by the Company or any other Person as of the date
of such forfeiture or divestment, and the Consultant shall, immediately upon the
request of the Company, deliver to the Company all stock certificates evidencing
such forfeited and/or divested Shares, duly endorsed for transfer to the Company
or its designee.

                                   SECTION 4

                                  MISCELLANEOUS

         4.1 Adjustments for Stock Splits, Stock Dividends, etc. If from time to
time during the term of this Agreement there is any stock split-up, stock
dividend, stock distribution or other reclassification of the Ordinary Shares of
the Company, any and all new, substituted or additional securities to which the
Consultant is entitled by reason of his ownership of the Shares shall be
immediately subject to the provisions of this Agreement in the same manner and
to the same extent as the Shares.

         4.2 Tax Issues. THE ISSUANCE OF THE SHARES TO THE CONSULTANT PURSUANT
TO THIS AGREEMENT INVOLVES COMPLEX AND SUBSTANTIAL TAX CONSIDERATIONS,
INCLUDING, WITHOUT LIMITATION, CONSIDERATION OF THE

                                      -3-
<PAGE>
ADVISABILITY OF THE CONSULTANT MAKING AN ELECTION UNDER SECTION 83(B) OF THE
UNITED STATES INTERNAL REVENUE CODE. THE CONSULTANT IS URGED TO CONSULT HIS OWN
TAX ADVISOR WITH RESPECT TO THE "TRANSACTIONS DESCRIBED IN THIS AGREEMENT. THE
COMPANY MAKES NO WARRANTIES OR REPRESENTATIONS WHATSOEVER TO THE CONSULTANT
REGARDING THE TAX CONSEQUENCES OF THE CONSULTANT'S PURCHASE OF THE SHARES OR
THIS AGREEMENT.

         4.3 Independent Contractor. Consultant acknowledges that he or she is a
consultant to Novirio, and not an employee or agent of the Company or any of its
subsidiaries. Nothing in this Agreement shall render Consultant an employee or
agent of the Company or any of its subsidiaries, nor authorize or empower
Consultant to speak for, represent or obligate the Company or any of its
subsidiaries in any way.

         4.4 Transferees. Each and every transferee or assignee of any Shares
from the Consultant (other than pursuant to a Sale of the Company) shall be
bound by and subject to all the terms and conditions of this Agreement on the
same basis as the Consultant is bound. So long as this Agreement is in effect,
the Company shall require as a condition precedent to the transfer of any Shares
by the Consultant that the transferee agrees in writing to be bound by, and
subject to, the terms and conditions of this Agreement and to ensure that such
transferees' transferees shall be likewise bound.

         4.5 Legends. The Company and Consultant agree that, so long as this
Agreement is in effect, the certificate representing the Shares will be stamped
or otherwise imprinted with legends in the following form:

         THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO AGREEMENTS,
COVENANTS AND RESTRICTIONS PROVIDED IN A STOCK RESTRICTION AGREEMENT DATED JUNE
__, 1998, AS AMENDED FROM TIME TO TIME, BETWEEN NOVIRIO PHARMACEUTICALS LIMITED
AND THE HOLDER OF THIS CERTIFICATE.

         THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD,
TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT UNDER SUCH ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE
CORPORATION TO THE EFFECT THAT SUCH REGISTRATION IS NOT REQUIRED.

         4.6 Remedies.

                  (a) The rights and remedies provided by this Agreement are
cumulative and the use of any one right or remedy by any party shall not
preclude or waive its right to use any or all other remedies. Said rights and
remedies are given in addition to any other rights the parties may have at law
or in equity.

                                      -4-
<PAGE>
                  (b) Without limitation of the foregoing, the parties hereto
agree that irreparable harm would occur in the event that any of the agreements
and provisions of this Agreement were not performed fully by the parties hereto
in accordance with their specific terms or were otherwise breached, and that
money damages are an inadequate remedy for breach of the Agreement because of
the difficulty of ascertaining and quantifying the amount of damage that will be
suffered by the parties hereto in the event that this Agreement is not performed
in accordance with its term or is otherwise breached. It is accordingly hereby
agreed that the parties hereto shall be entitled to an injunction or injunctions
to restrain, enjoin and prevent breaches of this Agreement, such remedy being in
addition to and not in lieu of any other rights and remedies to which the other
parties are entitled to at law or in equity.

                  (c) Except where a time period is otherwise specified, no
delay on the part of any party in the exercise of any right, power, privilege or
remedy hereunder shall operate as a waiver thereof, nor shall any exercise or
partial exercise of any such right, power, privilege or remedy preclude any
further exercise thereof or the exercise of any right, power, privilege or
remedy.

         4.7 Waivers and Amendments. The rights and obligations of the Company
and the rights and obligations of the Consultant under this Agreement may be
waived (either generally or in a particular instance, either retroactively or
prospectively, and either for a specified period of time or indefinitely) or
amended only with the written consent of the President of the Company, the
Consultant and the Board.

         4.8 Governing Law. This Agreement shall be governed by and construed
under the laws of the Commonwealth of Massachusetts (without giving effect to
any conflicts or choice of law provisions thereof that would cause the
application of the domestic substantive laws of any other jurisdiction).

         4.9 Successors and Assigns. Except as otherwise expressly provided
herein, the provisions hereof shall inure to the benefit of, and be binding
upon, the successors, assigns, heirs, executors and administrators of the
parties hereto.

         4.10 Entire Agreement. This Agreement constitutes the full and entire
understanding and agreement between the parties with regard to the subjects
hereof and supersedes all prior agreements and understandings, whether oral or
written, with respect thereto. Without limiting the foregoing, the Consultant
agrees that the provisions of this Agreement fulfill all obligations that the
Company may have to issue to the Consultant stock, options or equity interests
in the Company or any of its subsidiaries.

         4.11 Notices. Any and all notices provided for in this Agreement shall
be addressed: (i) if to the Company, to the principal executive office of the
Company; and (ii) if to the Consultant, to the address of the Consultant as
reflected on the signature page of this Agreement. Notices shall be deemed
delivered upon the earlier to occur of (i) receipt by the party to whom such
notice is directed; (ii) if sent by facsimile machine, on the day (other than a
Saturday, Sunday or legal holiday in the jurisdiction to which such notice is
directed) such notice is sent if sent (as evidenced by the facsimile confirmed
receipt) prior to 5:00 p.m. Eastern Standard Time and, if sent after 5:00 p.m.
Eastern Standard Time, on the day (other than a Saturday, Sunday or legal
holiday in the jurisdiction to which such notice is directed) after which such
notice is sent; (iii) on the first business day (other than a Saturday, Sunday
or legal

                                      -5-
<PAGE>
holiday in the jurisdiction to which such notice is directed) following the day
the same is deposited with the commercial carrier if sent by commercial
overnight delivery service; or (iv) the fifth day (other than a Saturday, Sunday
or legal holiday in the jurisdiction to which such notice is directed) following
deposit thereof with the U.S. Postal Service as aforesaid. Each party, by notice
duly given in accordance herewith, may specify a different address for the
giving of any notice hereunder.

         4.12 Severability. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions of this Agreement shall not in any way be affected or
impaired thereby, and each provision of this Agreement shall be enforced to the
fullest extent permitted by law.

         4.13 No Third Party Beneficiaries. There are no third party
beneficiaries of this Agreement.

         4.14 Duration. This Agreement shall be valid and continue in full force
and effect until the earlier of (i) the vesting of all of the Restricted Shares
in accordance with Section 3 hereof and (ii) the consummation of a Sale of the
Company.

         4.15 Securities Act Exemption. The Company and the Consultant agree
that this Agreement constitutes "a written contract relating to the
compensation" of the Consultant within the meaning of Rule 701 under the
Securities Act.

         4.16 Titles and Subtitles. The titles of the sections and subsections
of this Agreement are for convenience of reference only and are not to be
considered in construing this Agreement.

         4.17 Gender. The use of any gender in this Agreement shall be deemed to
be or include the other genders, and the use of the singular in this Agreement
shall be deemed to be or include the plural (and vice versa), wherever
appropriate.

         4.18 Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
constitute one agreement.

                       [SIGNATURES ARE ON FOLLOWING PAGE.]

                                      -6-
<PAGE>
         IN WITNESS WHEREOF, the Company and the Consultant have executed this
Agreement as of the day and year fast written above.

NOVIRIO PHARMACEUTICALS LIMITED            CONSULTANT:

By:/s/ B. Lucidi                           Signature: /s/ Jean-Pierre Sommadossi
   _______________________________                    __________________________
    Title:                                 Name:  Jean-Pierre Sommadossi
                                                 _______________________________

                                      -7-

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