Document:

EX-10.4

Exhibit 10.4

Halozyme Therapeutics, Inc.

Restricted Stock Units Agreement

under the

Halozyme Therapeutics, Inc.

2011 Stock Plan

1. Terminology. Unless otherwise provided in this Award Agreement, capitalized terms
used herein are defined in the Glossary at the end of this Award Agreement, the Notice, or the
Plan.

2. Vesting. All of the Restricted Stock Units are nonvested and forfeitable as of the
Grant Date. So long as your Service is continuous from the Grant Date through the applicable date
upon which vesting is scheduled to occur, the Restricted Stock Units will become vested and
nonforfeitable in accordance with the vesting schedule set forth in the Notice. Except for the
circumstances, if any, described in the Notice, none of the Restricted Stock Units will become
vested and nonforfeitable after your Service ceases.

3. Termination of Employment or Service. Unless otherwise provided in the Notice, if
your Service with the Company ceases for any reason, all Restricted Stock Units that are not then
vested and nonforfeitable will be forfeited to the Company immediately and automatically upon such
cessation without payment of any consideration therefor and you will have no further right, title
or interest in or to such Restricted Stock Units or the underlying shares of Stock.

4. Restrictions on Transfer. Neither this Award Agreement nor any of the Restricted
Stock Units may be assigned, transferred, pledged, hypothecated or disposed of in any way, whether
by operation of law or otherwise, and the Restricted Stock Units shall not be subject to execution,
attachment or similar process. All rights with respect to this Award Agreement and the Restricted
Stock Units shall be exercisable during your lifetime only by you or your guardian or legal
representative.

5. Dividend Equivalent Payments. On each dividend payment date for each cash dividend
(regular or extraordinary) on the Stock, the Company will credit your equity award account with
dividend equivalents in the form of additional Restricted Stock Units. All such additional
Restricted Stock Units shall be subject to the same vesting requirements applicable to the
Restricted Stock Units in respect of which they were credited and shall be settled in accordance
with, and at the time of, settlement of the vested Restricted Stock Units to which they are
related. The number of Restricted Stock Units to be credited shall equal the quotient, rounded to
such fraction as determined by the Committee, calculated by dividing (a) by (b), where “(a)” is the
product of (i) the cash dividend payable per share of Stock, multiplied by (ii) the number of
Restricted Stock Units credited to your account as of the record date, and “(b)” is the Fair Market
Value of a share of Stock on the dividend payment date. If your vested Restricted Stock Units have
been settled after the record date but prior to the dividend payment date, any Restricted Stock
Units that would be credited pursuant to the preceding sentence shall be settled on or as soon as
practicable after the dividend payment date. Nothing herein shall preclude the Committee from
exercising its discretion under the Plan to determine whether to eliminate fractional units or
credit fractional units to accounts, and the manner in which fractional units will be credited.

6. Settlement of Restricted Stock Units.

(a) Manner of Settlement. You are not required to make any monetary payment (other
than applicable tax withholding, if required) as a condition to settlement of the Restricted Stock
Units, the consideration for which shall be services rendered to the Company or for its benefit.
The Company will issue to you, in settlement of your Restricted Stock Units and subject to the
provisions of Section 7 below, the number of whole shares of Stock that equals the number of whole
Restricted Stock Units that become vested, and such vested Restricted Stock Units will terminate
and cease to be outstanding upon such issuance of the shares. Upon issuance of such shares, the
Company will determine the form of delivery (e.g., a stock certificate or electronic entry
evidencing such shares) and may deliver such shares on your behalf electronically to the Company’s
designated stock plan administrator or such other broker-dealer as the Company may choose at its
sole discretion, within reason.

(b) Timing of Settlement. Your Restricted Stock Units will be settled by the Company,
via the issuance of Stock as described herein, on the date that the Restricted Stock Units become
vested and nonforfeitable. However, if a scheduled issuance date falls on a Saturday, Sunday or
federal holiday, such issuance date shall instead fall on the next following day that the principal
executive offices of the Company are open for business. In all cases, the issuance and delivery of
shares under this Award Agreement is intended to comply with Treasury Regulation Section
1.409A-1(b)(4) and shall be construed and administered in such a manner. If you die after vesting
but before settlement, your Restricted Stock Units shall be paid to your estate.

7. Tax Withholding.

(a) On or before the time you receive a distribution of the shares subject to your Restricted
Stock Units, or at any time thereafter as requested by the Company, you may satisfy any federal,
state, local or foreign tax withholding obligation relating to your Restricted Stock Units by any
of the following means, which you must elect in advance by making an appropriate election via the
account established under your name with E*TRADE Financial or such other brokerage firm selected by
the Company (the “Brokerage Account”), or by such other method acceptable to the Committee if you
do not have a Brokerage Account, at such time or times specified by the Committee: (i) tendering a
cash payment that covers your tax withholding obligation by depositing such cash payment into your
Brokerage Account or providing it directly to the Company on or before the date your Restricted
Stock Units vest; or (ii) authorizing a net share settlement transaction under which the Company
will withhold from the shares otherwise issuable to you in connection with your Restricted Stock
Units a number of shares the Fair Market Value of which is sufficient to cover the tax withholding
obligation and issuing to you the remaining shares in settlement of your Restricted Stock Units on
the date your Restricted Stock Units vest. The Committee shall have discretion to allow any other
method of satisfying tax withholding obligations as it may determine to be adequate.

(b) Notwithstanding anything to the contrary set forth herein, the Company will satisfy the
tax withholding obligations relating to your Restricted Stock Units through a net share settlement
transaction (as described above) on the date your Restricted Stock Units vest in the following
circumstances: (i) you do not make an election in a form acceptable to the Committee on or prior to
the date your Restricted Stock Units vest regarding the method of satisfaction of your tax
withholding obligation; or (ii) you timely elect to satisfy your tax withholding obligation via
tendering a cash payment as provided above, but as of the date your Restricted Stock Units vest
there are insufficient funds in your Brokerage Account or received by the Company to cover the tax
withholding obligation.

(c) Any shares of Stock withheld to satisfy any tax withholding obligations shall not exceed
the amount determined by the applicable minimum statutory withholding rates.

(d) Unless the tax withholding obligations of the Company and/or any Affiliate are satisfied,
the Company shall have no obligation to deliver to you any Stock. In the event the Company’s
obligation to withhold arises prior to the delivery to you of Stock or it is determined after the
delivery of Stock to you that the amount of the Company’s withholding obligation was greater than
the amount withheld by the Company, you agree to indemnify and hold the Company harmless from any
failure by the Company to withhold the proper amount.

8. Adjustments for Corporate Transactions and Other Events.

(a) Stock Dividend, Stock Split and Reverse Stock Split. Upon a stock dividend of, or
stock split or reverse stock split affecting, the Stock, the number of outstanding Restricted Stock
Units shall, without further action of the Committee, be adjusted to reflect such event; provided,
however, that any fractional Restricted Stock Units resulting from any such adjustment shall be
eliminated. Adjustments under this paragraph will be made by the Committee, whose determination as
to what adjustments, if any, will be made and the extent thereof will be final, binding and
conclusive.

(b) Merger, Consolidation and Other Events. If the Company shall be the surviving or
resulting corporation in any merger or consolidation and the Stock shall be converted into other
securities, the Restricted Stock Units shall pertain to and apply to the securities to which a
holder of the number of shares of Stock subject to the Restricted Stock Units would have been
entitled. If the stockholders of the Company receive by reason of any distribution in total or
partial liquidation or pursuant to any merger of the Company or acquisition of its assets,
securities of another entity or other property (including cash), then the rights of the Company
under this Award Agreement shall inure to the benefit of the Company’s successor, and this Award
Agreement shall apply to the securities or other property (including cash) to which a holder of the
number of shares of Stock subject to the Restricted Stock Units would have been entitled, in the
same manner and to the same extent as the Restricted Stock Units. Notwithstanding the foregoing,
in the event of any transaction resulting in a Change in Control of the Company, the Restricted
Stock Units will terminate upon the effective time of such Change in Control unless provision is
made by the Company in connection with the transaction for the continuation or assumption of the
Restricted Stock Units by, or for the substitution of equivalent awards of, the surviving or
successor entity or a parent thereof. All determinations as to whether any, some or all
outstanding Restricted Stock Units and, if any, which such Restricted Stock Units, will be
continued, assumed or substituted in a transaction and whether any such substitution is for
equivalent awards shall be made in the sole discretion of the Committee, and such continuation,
assumption, or substitution may be effectuated without your consent.

9. Non-Guarantee of Employment or Service Relationship. Nothing in the Plan or this
Award Agreement shall alter your employment status or other service relationship with the Company,
nor be construed as a contract of employment or service relationship between the Company and you,
or as a contractual right of you to continue in the employ of, or in a service relationship with,
the Company for any period of time, or as a limitation of the right of the Company to discharge you
at any time with or without cause or notice and whether or not such discharge results in the
forfeiture of any nonvested and forfeitable Restricted Stock Units or any other adverse effect on
your interests under the Plan.

10. Rights as Stockholder. You shall not have any of the rights of a stockholder with
respect to any shares of Stock that may be issued in settlement of the Restricted Stock Units until
such shares of Stock have been issued to you. No adjustment shall be made for dividends,
distributions, or other rights for which the record date is prior to the date such shares are
issued, except as provided in Section 5 of this Award Agreement with respect to dividend equivalent
payments or as otherwise permitted under the Plan.

11. The Company’s Rights. The existence of the Restricted Stock Units shall not
affect in any way the right or power of the Company or its stockholders to make or authorize any or
all adjustments, recapitalizations, reorganizations, or other changes in the Company’s capital
structure or its business, or any merger or consolidation of the Company, or any issue of bonds,
debentures, preferred or other stocks with preference ahead of or convertible into, or otherwise
affecting the Stock or the rights thereof, or the dissolution or liquidation of the Company, or any
sale or transfer of all or any part of the Company’s assets or business, or any other corporate act
or proceeding, whether of a similar character or otherwise.

12. Restrictions on Issuance of Shares. The issuance of shares of Stock upon
settlement of the Restricted Stock Units shall be subject to and in compliance with all applicable
requirements of federal, state, or foreign law with respect to such securities. No shares of Stock
may be issued hereunder if the issuance of such shares would constitute a violation of any
applicable federal, state, or foreign securities laws or other law or regulations or the
requirements of any stock exchange or market system upon which the Stock may then be listed. The
inability of the Company to obtain from any regulatory body having jurisdiction the authority, if
any, deemed by the Company’s legal counsel to be necessary to the lawful issuance of any shares
subject to the Restricted Stock Units shall relieve the Company of any liability in respect of the
failure to issue such shares as to which such requisite authority shall not have been obtained. As
a condition to the settlement of the Restricted Stock Units, the Company may require you to satisfy
any qualifications that may be necessary or appropriate, to evidence compliance with any applicable
law or regulation, and to make any representation or warranty with respect thereto as may be
requested by the Company.

13. Notices. All notices and other communications made or given pursuant to this
Award Agreement shall be given in writing and shall be deemed effectively given upon receipt or, in
the case of notices delivered by the Company to you, five (5) days after deposit in the United
States mail, postage prepaid, addressed to you at the last address you provided to the Company, or
in the case of notices delivered to the Company by you, addressed to the Committee, care of the
Company for the attention of its Secretary at its principal executive office or, in either case, if
the receiving party consents in advance, transmitted and received via telecopy or via such other
electronic transmission mechanism as may be available to the parties. Notwithstanding the
foregoing, the Company may, in its sole discretion, decide to deliver any documents related to
participation in the Plan and this award of Restricted Stock Units by electronic means or to
request your consent to participate in the Plan or accept this award of Restricted Stock Units by
electronic means. You hereby consent to receive such documents by electronic delivery and, if
requested, to agree to participate in the Plan through an on-line or electronic system established
and maintained by the Company or another third party designated by the Company.

14. Entire Agreement. This Award Agreement, together with the relevant Notice and the
Plan, contain the entire agreement between the parties with respect to the Restricted Stock Units
granted hereunder. Any oral or written agreements, representations, warranties, written
inducements, or other communications made prior to the execution of this Award Agreement with
respect to the Restricted Stock Units granted hereunder shall be void and ineffective for all
purposes.

15. Amendment. This Award Agreement may be amended from time to time by the Committee
in its discretion; provided, however, that this Award Agreement may not be
modified in a manner that would have a materially adverse effect on the Restricted Stock Units as
determined in the discretion of the Committee, except as provided in the Plan or in a written
document signed by each of the parties hereto.

16. 409A Savings Clause. This Award Agreement and the Restricted Stock Units granted
hereunder are intended to fit within the “short-term deferral” exemption from Section 409A of the
Code as set forth in Treasury Regulation Section 1.409A-1(b)(4). In administering this Award
Agreement, the Company shall interpret this Award Agreement in a manner consistent with such
exemption. Notwithstanding the foregoing, if it is determined that the Restricted Stock Units fail
to satisfy the requirements of the short-term deferral rule and are otherwise deferred compensation
subject to Section 409A, and if you are a “Specified Employee” (within the meaning set forth
Section 409A(a)(2)(B)(i) of the Code) as of the date of your separation from service (within the
meaning of Treasury Regulation Section 1.409A-1(h)), then the issuance of any shares that would
otherwise be made upon the date of the separation from service or within the first six (6) months
thereafter will not be made on the originally scheduled date(s) and will instead be issued in a
lump sum on the date that is six (6) months and one day after the date of the separation from
service, but if and only if such delay in the issuance of the shares is necessary to avoid the
imposition of additional taxation on you in respect of the shares under Section 409A of the Code.
Each installment of shares that vests is intended to constitute a “separate payment” for purposes
of Section 409A of the Code and Treasury Regulation Section 1.409A-2(b)(2). For purposes of
Section 409A of the Code, the payment of dividend equivalents under Section 5 of this Award
Agreement shall be construed as earnings and the time and form of payment of such dividend
equivalents shall be treated separately from the time and form of payment of the underlying
Restricted Stock Units.

17. No Obligation to Minimize Taxes. The Company has no duty or obligation to
minimize the tax consequences to you of this award of Restricted Stock Units and shall not be
liable to you for any adverse tax consequences to you arising in connection with this award. You
are hereby advised to consult with your own personal tax, financial and/or legal advisors regarding
the tax consequences of this award and by signing the Notice, you have agreed that you have done so
or knowingly and voluntarily declined to do so.

18. Conformity with Plan. This Award Agreement is intended to conform in all respects
with, and is subject to all applicable provisions of, the Plan. Inconsistencies between this Award
Agreement and the Plan shall be resolved in accordance with the terms of the Plan. In the event of
any ambiguity in this Award Agreement or any matters as to which this Award Agreement is silent,
the Plan shall govern. A copy of the Plan is available on the Company’s intranet or upon written
request to the Committee.

19. No Funding. This Award Agreement constitutes an unfunded and unsecured promise by
the Company to issue shares of Stock in the future in accordance with its terms. You have the
status of a general unsecured creditor of the Company as a result of receiving the grant of
Restricted Stock Units.

20. Effect on Other Employee Benefit Plans. The value of the Restricted Stock Units
subject to this Award Agreement shall not be included as compensation, earnings, salaries, or other
similar terms used when calculating your benefits under any employee benefit plan sponsored by the
Company or any Affiliate, except as such plan otherwise expressly provides. The Company expressly
reserves its rights to amend, modify, or terminate any of the Company’s or any Affiliate’s employee
benefit plans.

21. Governing Law. The validity, construction, and effect of this Award Agreement,
and of any determinations or decisions made by the Committee relating to this Award Agreement, and
the rights of any and all persons having or claiming to have any interest under this Award
Agreement, shall be determined exclusively in accordance with the laws of the State of Delaware,
without regard to its provisions concerning the applicability of laws of other jurisdictions. Any
suit with respect hereto will be brought in the federal or state courts in the district which
includes the city or town in which the Company’s principal executive office is located, and you
hereby agree and submit to the personal jurisdiction and venue thereof.

22. Headings. The headings in this Award Agreement are for reference purposes only
and shall not affect the meaning or interpretation of this Award Agreement.

23. Electronic Delivery of Documents. By your signing the Notice, you (i) consent to
the electronic delivery of this Award Agreement, all information with respect to the Plan and the
Restricted Stock Units, and any reports of the Company provided generally to the Company’s
stockholders; (ii) acknowledge that you may receive from the Company a paper copy of any documents
delivered electronically at no cost to you by contacting the Company by telephone or in writing;
(iii) further acknowledge that you may revoke your consent to the electronic delivery of documents
at any time by notifying the Company of such revoked consent by telephone, postal service or
electronic mail; and (iv) further acknowledge that you understand that you are not required to
consent to electronic delivery of documents.

24. No Future Entitlement. By your signing the Notice, you acknowledge and agree
that: (i) the grant of a restricted stock unit award is a one-time benefit which does not create
any contractual or other right to receive future grants of restricted stock units, or compensation
in lieu of restricted stock units, even if restricted stock units have been granted repeatedly in
the past; (ii) all determinations with respect to any such future grants and the terms thereof will
be at the sole discretion of the Committee; (iii) the value of the restricted stock units is an
extraordinary item of compensation which is outside the scope of your employment contract, if any;
(iv) the value of the restricted stock units is not part of normal or expected compensation or
salary for any purpose, including, but not limited to, calculating any termination, severance,
resignation, redundancy, end of service payments or similar payments, or bonuses, long-service
awards, pension or retirement benefits; (v) the vesting of the restricted stock units ceases upon
termination of Service with the Company or transfer of employment from the Company, or other
cessation of eligibility for any reason, except as may otherwise be explicitly provided in this
Award Agreement; (vi) the Company does not guarantee any future value of the restricted stock
units; and (vii) no claim or entitlement to compensation or damages arises if the restricted stock
units decrease or do not increase in value and you irrevocably release the Company from any such
claim that does arise.

25. Personal Data. For purposes of the implementation, administration and management
of the restricted stock units or the effectuation of any acquisition, equity or debt financing,
joint venture, merger, reorganization, consolidation, recapitalization, business combination,
liquidation, dissolution, share exchange, sale of stock, sale of material assets or other similar
corporate transaction involving the Company (a “Corporate Transaction”), you consent, by execution
of the Notice, to the collection, receipt, use, retention and transfer, in electronic or other
form, of your personal data by and among the Company and its third party vendors or any potential
party to a potential Corporate Transaction. You understand that personal data (including but not
limited to, name, home address, telephone number, employee number, employment status, social
security number, tax identification number, date of birth, nationality, job and payroll location,
data for tax withholding purposes and shares awarded, cancelled, vested and unvested) may be
transferred to third parties assisting in the implementation, administration and management of the
restricted stock units or the effectuation of a Corporate Transaction and you expressly authorize
such transfer as well as the retention, use, and the subsequent transfer of the data by the
recipient(s). You understand that these recipients may be located in your country or elsewhere,
and that the recipient’s country may have different data privacy laws and protections than your
country. You understand that data will be held only as long as is necessary to implement,
administer and manage the restricted stock units or effect a Corporate Transaction. You understand
that you may, at any time, request a list with the names and addresses of any potential recipients
of the personal data, view data, request additional information about the storage and processing of
data, require any necessary amendments to data or refuse or withdraw the consents herein, in any
case without cost, by contacting in writing the Company’s Secretary. You understand, however, that
refusing or withdrawing your consent may affect your ability to accept a restricted stock unit
award.

26. Counterparts. The Notice may be executed in counterparts, each of which shall be
deemed an original, but all of which together shall constitute one and the same instrument.

{Glossary begins on next page}

1

GLOSSARY

(a) “Affiliate” means any entity, whether now or hereafter existing, which controls, is
controlled by, or is under common control with Halozyme Therapeutics, Inc. (including but not
limited to joint ventures, limited liability companies, and partnerships). For this purpose, the
term “control” (including the term “controlled by”) means the possession, direct or indirect, of
the power to direct or cause the direction of the management and policies of the relevant entity,
whether through the ownership of voting securities, by contract or otherwise.

(b) “Award Agreement” means this document, as amended from time to time, together with the
Plan which is incorporated herein by reference.

(c) “Code” means the Internal Revenue Code of 1986, as amended, and the Treasury regulations
and other guidance promulgated thereunder.

(d) “Committee” means the Compensation Committee or other committee of the Board of Directors
of the Company duly appointed to administer the Plan and having such powers as shall be specified
by the Board of Directors.

(e) “Company” means Halozyme Therapeutics, Inc. and its Affiliates, except where the context
otherwise requires. For purposes of determining whether a Change in Control (as defined in the
Plan) has occurred, Company shall mean only Halozyme Therapeutics, Inc.

(f) “Fair Market Value” has the meaning set forth in the Plan. The Plan generally defines
Fair Market Value to mean the closing price per share of Stock on the relevant date on the
principal exchange or market on which the Stock is then listed or admitted to trading or, if no
sale is reported for that date, the last preceding business day on which a sale was reported.

(g) “Grant Date” means the effective date of a grant of Restricted Stock Units made to you as
set forth in the relevant Notice.

(h) “Notice” means the statement, letter or other written notification provided to you by the
Company setting forth the terms of a grant of Restricted Stock Units made to you.

(i) “Plan” means the Halozyme Therapeutics, Inc. 2011 Stock Incentive Plan, as amended from
time to time.

(j) “Restricted Stock Unit” means the Company’s commitment to issue one share of Stock at a
future date, subject to the terms of the Award Agreement and the Plan.

(k) “Service” means your employment, service as a non-executive director, or other service
relationship with the Company and its Affiliates. Your Service will be considered to have ceased
with the Company and its Affiliates if, immediately after a sale, merger, or other corporate
transaction, the trade, business, or entity with which you are employed or otherwise have a service
relationship is not Halozyme Therapeutics, Inc. or its successor or an Affiliate of Halozyme
Therapeutics, Inc. or its successor.

(l) “Stock” means the common stock, US$0.001 par value per share, of Halozyme Therapeutics,
Inc., as adjusted from time to time in accordance with Section 4.2 of the Plan.

(m) “You” or “Your” means the recipient of the Restricted Stock Units as reflected on the
applicable Notice. Whenever the word “you” or “your” is used in any provision of this Award
Agreement under circumstances where the provision should logically be construed, as determined by
the Committee, to apply to the estate, personal representative, or beneficiary to whom the
Restricted Stock Units may be transferred by will or by the laws of descent and distribution, the
words “you” and “your” shall be deemed to include such person.

{End of Agreement}

2EX-10.5

Exhibit 10.5

Halozyme Therapeutics, Inc.

Restricted Stock Award Agreement

under the

Halozyme Therapeutics, Inc.

2011 Stock Plan

1. Terminology. Unless otherwise provided in this Award Agreement, capitalized words
used herein are defined in the Glossary at the end of this Award Agreement, the Notice, or the
Plan.

2. Termination of Employment or Service.

(a) If your Service with the Company ceases for any reason, except as otherwise specified in
the Notice, all Award Shares that are not then vested and nonforfeitable will be immediately
forfeited by you and transferred to the Company upon such cessation for no consideration. Any
accrued dividends attributable to such forfeited Award Shares shall also be forfeited if and when
the Award Shares are forfeited.

(b) You acknowledge and agree that upon the forfeiture of any unvested Award Shares, (i) your
right to vote and to receive cash dividends on, and all other rights, title or interest in, to or
with respect to, the forfeited Award Shares shall automatically, without further act, terminate and
(ii) the forfeited Award Shares shall be returned to the Company. You hereby irrevocably appoint
(which appointment is coupled with an interest) the Company as your agent and attorney-in-fact to
take any necessary or appropriate action to cause the forfeited Award Shares to be returned to the
Company, including without limitation executing and delivering stock powers and instruments of
transfer, making endorsements and/or making, initiating or issuing instructions or entitlement
orders, all in your name and on your behalf. You hereby ratify and approve all acts done by the
Company as such attorney-in-fact. Without limiting the foregoing, you expressly acknowledge and
agree that any transfer agent for the Stock of the Company is fully authorized and protected in
relying on, and shall incur no liability in acting on, any documents, instruments, endorsements,
instructions, orders or communications from the Company in connection with the forfeited Award
Shares or the transfer thereof, and that any such transfer agent is a third party beneficiary of
this Award Agreement.

3. Restrictions on Transfer and Receipt of Cash Dividends.

(a) Until an Award Share becomes vested and nonforfeitable, it may not be sold, assigned,
transferred, pledged, hypothecated or disposed of in any way (whether by operation of law or
otherwise), except by will or the laws of descent and distribution, and shall not be subject to
execution, attachment or similar process.

(b) Any attempt to dispose of any such Award Shares in contravention of the restrictions set
forth in Section 3(a) shall be null and void and without effect. The Company shall not be required
to (i) transfer on its books any Award Shares that have been sold or transferred in contravention
of this Award Agreement or (ii) treat as the owner of Award Shares, or otherwise accord voting,
dividend or liquidation rights to, any transferee to whom Award Shares have been transferred in
contravention of this Award Agreement.

(c) Any regular or extraordinary cash dividends that become payable with respect to an
unvested Award Share will be accrued and held by the Company or an escrow agent appointed by the
Committee until the Award Share becomes vested and will be paid to you within fifteen days after
the date on which the related Award Share becomes vested or will be forfeited if and when the
related Award Share is forfeited.

4. Stock Certificates.

(a) You are reflected as the owner of record of the Award Shares as of the Grant Date on the
Company’s books. The Company or an escrow agent appointed by the Committee will hold in escrow the
share certificates for safekeeping, or the Company may otherwise retain the Award Shares in
uncertificated book entry form, until the Award Shares become vested and nonforfeitable. Until the
Award Shares become vested and nonforfeitable, any share certificates representing such shares will
include a legend to the effect that you may not sell, assign, transfer, pledge, or hypothecate the
Award Shares. As soon as practicable after vesting of an Award Share, the Company or its escrow
agent will deliver the Award Share to you, subject to the provisions of Section 5 of this Award
Agreement. The Company will determine the form of delivery (e.g., a stock certificate or
electronic entry evidencing such shares) and may deliver such share on your behalf electronically
to the Company’s designated stock plan administrator or such other broker-dealer as the Company may
choose at its sole discretion, within reason.

(b) You are not required to make any monetary payment (other than applicable tax withholding,
if any) as a condition to receiving the Award Shares, the consideration for which shall be past
services actually rendered or, if none, future services to be rendered to the Company or for its
benefit. Notwithstanding the foregoing, if required by applicable state corporate law, you shall
furnish consideration in the form of cash or past services rendered to the Company or for its
benefit having a value not less than the par value of the Award Shares.

5. Tax Election and Tax Withholding.

(a) You hereby acknowledge that you have been advised by the Company to seek independent tax
advice from your own advisors regarding the availability and advisability of making an election
under Section 83(b) of the Internal Revenue Code of 1986, as amended, and that any such election,
if made, must be made within 30 days of the Grant Date. You expressly acknowledge that you are
solely responsible for filing any such Section 83(b) election with the appropriate governmental
authorities, irrespective of the fact that such election is also delivered to the Company. You may
not rely on the Company or any of its officers, directors or employees for tax or legal advice
regarding this award. You acknowledge that you have sought tax and legal advice from your own
advisors regarding this award or have voluntarily and knowingly foregone such consultation.

(b) On or before the time you receive the Award Shares, or at any time thereafter as requested
by the Company, you may satisfy any federal, state, local or foreign tax withholding obligation
relating to your Award Shares by any of the following means, which you must elect in advance by
making an appropriate election via the account established under your name with E*TRADE Financial
or such other brokerage firm selected by the Company (the “Brokerage Account”) at such time or
times specified by the Committee: (i) tendering a cash payment that covers your tax withholding
obligation by depositing such cash payment into your Brokerage Account or providing it directly to
the Company on or before the date your Award Shares vest; or (ii) authorizing a sell-to-cover
transaction, which involves the automatic sale by E*TRADE Financial or such other brokerage firm
selected by the Company, through one or more block trades, of the number of Award Shares that vest
with the value necessary to satisfy the tax withholding obligations, the assignment to the Company
of the proceeds of the sale for subsequent payment to the relevant tax authorities, and the release
or delivery to you of the remaining vested Award Shares. The Committee shall have discretion to
allow any other method of satisfying tax withholding obligations as it may determine to be
adequate.

(c) If you do not make an election via your Brokerage Account on or prior to the date your
Award Shares vest regarding the method of satisfaction of your tax withholding obligation, or if
you timely elect to satisfy your tax withholding obligation via tendering a cash payment as
provided above, but as of the date your Award Shares vest there are insufficient funds in your
Brokerage Account or received by the Company to cover the tax withholding obligation, then such tax
withholding obligation shall be satisfied through a sell-to-cover transaction (as described above).

(d) Notwithstanding anything to the contrary set forth in Section 5(b) or 5(c) above,
including any election that you may have made through your Brokerage Account, the Company will
satisfy the tax withholding obligations relating to your Award Shares by withholding from the
shares otherwise deliverable to you in connection with your Award Shares, or redeeming Award
Shares, and releasing or delivering to you the remaining shares if on the date your Award Shares
vest you are an executive officer of the Company and you have not tendered a cash payment on or
before the vesting date in full satisfaction of the tax withholding obligation.

(e) Any shares withheld or redeemed to satisfy any tax withholding obligations shall not
exceed the amount determined by the applicable minimum statutory withholding rates.

(f) Unless the tax withholding obligations of the Company and/or any Affiliate are satisfied,
the Company shall have no obligation to deliver to you any Stock. If any tax withholding
obligation is not satisfied in full through one of the methods described in this Section 5, the
Company shall have the right to deduct such taxes from any compensation or any other payment of any
kind due you (including the right to withhold the issuance or delivery of shares of Stock or to
redeem Award Shares). In the event the Company’s obligation to withhold arises prior to the
delivery to you of Stock or it is determined after the delivery of Stock to you that the amount of
the Company’s withholding obligation was greater than the amount withheld by the Company, you agree
to indemnify and hold the Company harmless from any failure by the Company to withhold the proper
amount.

6. Adjustments for Corporate Transactions and Other Events.

(a) Stock Dividend, Stock Split and Reverse Stock Split. Upon a stock dividend of, or
stock split or reverse stock split affecting, the Stock, the number of Award Shares and the number
of such Award Shares that are nonvested and forfeitable shall, without further action of the
Committee, be adjusted to reflect such event. The Committee shall make adjustments, in its
discretion, to address the treatment of fractional shares with respect to the Award Shares as a
result of the stock dividend, stock split or reverse stock split; provided that such adjustments do
not result in the issuance of fractional Award Shares. Adjustments under this Section 6 will be
made by the Committee, whose determination as to what adjustments, if any, will be made and the
extent thereof will be final, binding and conclusive.

(b) Binding Nature of Agreement. The terms and conditions of this Award Agreement
shall apply with equal force to any additional and/or substitute securities received by you in
exchange for, or by virtue of your ownership of, the Award Shares, to the same extent as the Award
Shares with respect to which such additional and/or substitute securities are distributed, whether
as a result of any spin-off, stock split-up, stock dividend, stock distribution, other
reclassification of the Stock of the Company, or similar event, except as otherwise determined by
the Committee. If the Award Shares are converted into or exchanged for, or stockholders of the
Company receive by reason of any distribution in total or partial liquidation or pursuant to any
merger of the Company or acquisition of its assets, securities of another entity, or other property
(including cash), then the rights of the Company under this Award Agreement shall inure to the
benefit of the Company’s successor, and this Award Agreement shall apply to the securities or other
property (including cash) received upon such conversion, exchange or distribution in the same
manner and to the same extent as the Award Shares.

7. Non-Guarantee of Employment or Service Relationship. Nothing in the Plan or this
Award Agreement shall alter your employment status or other service relationship with the Company,
nor be construed as a contract of employment or service relationship between the Company and you,
or as a contractual right of you to continue in the employ of, or in a service relationship with,
the Company for any period of time, or as a limitation of the right of the Company to discharge you
at any time with or without cause or notice and whether or not such discharge results in the
forfeiture of any Award Shares or any other adverse effect on your interests under the Plan.

8. Rights as Stockholder. Except as otherwise provided in this Award Agreement with
respect to the nonvested and forfeitable Award Shares and the payment of regular or extraordinary
cash dividends thereon, you will possess all incidents of ownership of the Award Shares, including
the right to vote the Award Shares and receive stock dividends and/or other distributions declared
on the Award Shares.

9. The Company’s Rights. The existence of the Award Shares shall not affect in any
way the right or power of the Company or its stockholders to make or authorize any or all
adjustments, recapitalizations, reorganizations or other changes in the Company’s capital structure
or its business, or any merger or consolidation of the Company, or any issue of bonds, debentures,
preferred or other stocks with preference ahead of or convertible into, or otherwise affecting the
Stock or the rights thereof, or the dissolution or liquidation of the Company, or any sale or
transfer of all or any part of the Company’s assets or business, or any other corporate act or
proceeding, whether of a similar character or otherwise.

10. Notices. All notices and other communications made or given pursuant to this
Award Agreement shall be given in writing and shall be deemed effectively given upon receipt or, in
the case of notices delivered by the Company to you, five (5) days after deposit in the United
States mail, postage prepaid, addressed to you at the last address you provided to the Company, or
in the case of notices delivered to the Company by you, addressed to the Committee, care of the
Company for the attention of its Secretary at its principal executive office or, in either case, if
the receiving party consents in advance, transmitted and received via telecopy or via such other
electronic transmission mechanism as may be available to the parties. Notwithstanding the
foregoing, the Company may, in its sole discretion, decide to deliver any documents related to
participation in the Plan and this award of Restricted Stock by electronic means or to request your
consent to participate in the Plan or accept this award of Restricted Stock by electronic means.
You hereby consent to receive such documents by electronic delivery and, if requested, to agree to
participate in the Plan through an on-line or electronic system established and maintained by the
Company or another third party designated by the Company.

11. Entire Agreement. This Award Agreement, together with the relevant Notice and the
Plan, contain the entire agreement between the parties with respect to the Award Shares granted
hereunder. Any oral or written agreements, representations, warranties, written inducements, or
other communications made prior to the execution of this Award Agreement with respect to the Award
Shares granted hereunder shall be void and ineffective for all purposes.

12. Amendment. This Award Agreement may be amended from time to time by the Committee
in its discretion; provided, however, that this Award Agreement may not be
modified in a manner that would have a materially adverse effect on your rights with respect to the
Award Shares as determined in the discretion of the Committee, except as provided in the Plan or in
a written document signed by each of the parties hereto.

13. Conformity with Plan. This Award Agreement is intended to conform in all respects
with, and is subject to all applicable provisions of, the Plan. Inconsistencies between this Award
Agreement and the Plan shall be resolved in accordance with the terms of the Plan. In the event of
any ambiguity in this Award Agreement or any matters as to which this Award Agreement is silent,
the Plan shall govern. A copy of the Plan is available on the Company’s intranet or upon written
request to the Committee.

14. Effect on Other Employee Benefit Plans. The value of the Award Shares subject to
this Award Agreement shall not be included as compensation, earnings, salaries, or other similar
terms used when calculating your benefits under any employee benefit plan sponsored by the Company
or any Affiliate, except as such plan otherwise expressly provides. The Company expressly reserves
its rights to amend, modify, or terminate any of the Company’s or any Affiliate’s employee benefit
plans.

15. Governing Law. The validity, construction, and effect of this Award Agreement,
and of any determinations or decisions made by the Committee relating to this Award Agreement, and
the rights of any and all persons having or claiming to have any interest under this Award
Agreement, shall be determined exclusively in accordance with the laws of the State of Delaware,
without regard to its provisions concerning the applicability of laws of other jurisdictions. Any
suit with respect hereto will be brought in the federal or state courts in the district which
includes the city or town in which the Company’s principal executive office is located, and you
hereby agree and submit to the personal jurisdiction and venue thereof.

16. Headings. The headings in this Award Agreement are for reference purposes only
and shall not affect the meaning or interpretation of this Award Agreement.

17. Counterparts. The Notice may be executed in counterparts, each of which shall be
deemed an original, but all of which together shall constitute one and the same instrument.

18. Electronic Delivery of Documents. By your signing the Notice, you (i) consent to
the electronic delivery of this Award Agreement, all information with respect to the Plan and the
Award Shares and any reports of the Company provided generally to the Company’s stockholders;
(ii) acknowledge that you may receive from the Company a paper copy of any documents delivered
electronically at no cost to you by contacting the Company by telephone or in writing;
(iii) further acknowledge that you may revoke your consent to the electronic delivery of documents
at any time by notifying the Company of such revoked consent by telephone, postal service or
electronic mail; and (iv) further acknowledge that you understand that you are not required to
consent to electronic delivery of documents.

19. No Future Entitlement. By your signing the Notice, you acknowledge and agree
that: (i) the grant of these Award Shares is a one-time benefit which does not create any
contractual or other right to receive future grants of stock, or compensation in lieu of stock
grants, even if stock grants have been granted repeatedly in the past; (ii) all determinations with
respect to any such future grants, including, but not limited to, the times when stock grants shall
be granted, the maximum number of shares subject to each stock grant, and the times or conditions
under which restrictions on such stock grants shall lapse, will be at the sole discretion of the
Committee; (iii) the value of this stock grant is an extraordinary item of compensation which is
outside the scope of your employment contract, if any; (iv) the value of this stock grant is not
part of normal or expected compensation or salary for any purpose, including, but not limited to,
calculating any termination, severance, resignation, redundancy, end of service payments or similar
payments, or bonuses, long-service awards, pension or retirement benefits; (v) the vesting of these
Award Shares ceases upon termination of employment with the Company or transfer of employment from
the Company, or other cessation of eligibility for any reason, except as may otherwise be
explicitly provided in this Award Agreement; (vi) the Company does not guarantee any future value
of these Award Shares; and (vii) no claim or entitlement to compensation or damages arises if these
Award Shares do not increase in value and you irrevocably release the Company from any such claim
that does arise.

20. Personal Data. For purposes of the implementation, administration and management
of the stock grant or the effectuation of any acquisition, equity or debt financing, joint venture,
merger, reorganization, consolidation, recapitalization, business combination, liquidation,
dissolution, share exchange, sale of stock, sale of material assets or other similar corporate
transaction involving the Company (a “Corporate Transaction”), you consent, by execution of the
Notice, to the collection, receipt, use, retention and transfer, in electronic or other form, of
your personal data by and among the Company and its third party vendors or any potential party to a
potential Corporate Transaction. You understand that personal data (including but not limited to,
name, home address, telephone number, employee number, employment status, social security number,
tax identification number, date of birth, nationality, job and payroll location, data for tax
withholding purposes and shares awarded, cancelled, vested and unvested) may be transferred to
third parties assisting in the implementation, administration and management of the stock grant or
the effectuation of a Corporate Transaction and you expressly authorize such transfer as well as
the retention, use, and the subsequent transfer of the data by the recipient(s). You understand
that these recipients may be located in your country or elsewhere, and that the recipient’s country
may have different data privacy laws and protections than your country. You understand that data
will be held only as long as is necessary to implement, administer and manage the stock grant or
effect a Corporate Transaction. You understand that you may, at any time, request a list with the
names and addresses of any potential recipients of the personal data, view data, request additional
information about the storage and processing of data, require any necessary amendments to data or
refuse or withdraw the consents herein, in any case without cost, by contacting in writing the
Company’s Secretary. You understand, however, that refusing or withdrawing your consent may affect
your ability to accept a stock grant.

{Glossary begins on next page}

1

GLOSSARY

(a) “Affiliate” means any entity, whether now or hereafter existing, which controls, is
controlled by, or is under common control with Halozyme Therapeutics, Inc. (including but not
limited to joint ventures, limited liability companies and partnerships). For this purpose, the
term “control” (including the term “controlled by”) means the possession, direct or indirect, of
the power to direct or cause the direction of the management and policies of the relevant entity,
whether through the ownership of voting securities, by contract or otherwise.

(b) “Committee” means the Compensation Committee or other committee of the Board of Directors
of the Company duly appointed to administer the Plan and having such powers as shall be specified
by the Board of Directors.

(c) “Company” means Halozyme Therapeutics, Inc. and its Affiliates, except where the context
otherwise requires. For purposes of determining whether a Change in Control (as defined under the
Plan) has occurred, Company shall mean only Halozyme Therapeutics, Inc.

(d) “Notice” means the statement, letter or other written notification provided to you by the
Company setting forth the terms of a grant of Award Shares made to you.

(e) “Service” means your employment or other service relationship with the Company and its
Affiliates. Your Service will be considered to have ceased with the Company and its Affiliates if,
immediately after a sale, merger or other corporate transaction, the trade, business or entity with
which you are employed or otherwise have a service relationship is not Halozyme Therapeutics, Inc.
or its successor, or an Affiliate of Halozyme Therapeutics, Inc. or its successor.

(f) “Stock” means the common stock, US$0.001 par value per share, of Halozyme Therapeutics,
Inc., as adjusted from time to time in accordance with Section 4.2 of the Plan.

(g) “You”; “Your”. You means the recipient of the Award Shares as reflected in the first
paragraph of this Award Agreement. Whenever the word “you” or “your” is used in any provision of
this Award Agreement under circumstances where the provision should logically be construed, as
determined by the Committee, to apply to the estate, personal representative, or beneficiary to
whom the Award Shares may be transferred by will or by the laws of descent and distribution, the
words “you” and “your” shall be deemed to include such person.

{End of Agreement}

IMPORTANT FEDERAL TAX INFORMATION

INSTRUCTIONS REGARDING SECTION 83(b) ELECTIONS

	1.	 	The 83(b) Election is irrevocable. The 83(b) Election is a voluntary election that
is available to you. It is your decision whether to file an 83(b) Election.

	2.	 	If you choose to make an 83(b) Election, the 83(b) Election Form must be filed with the
Internal Revenue Service within 30 days of the Grant Date; no exceptions to this deadline are
made. You should send the election to the internal revenue service center located at the
address to which you send your federal income tax return (IRS form 1040) based on your place
of residence. The election should be sent via certified mail with return receipt
requested or a delivery service that provides proof of delivery.

	3.	 	You must deliver a copy of the 83(b) Election Form to the Corporate Secretary or other
designated officer of the Company as soon as practicable after you receive proof that the
original was received by the Internal Revenue Service. Irrespective of the fact that a copy
of your 83(b) Election Form is to be delivered to the Company, you remain solely responsible
for properly filing the original with the Internal Revenue Service.

	4.	 	In addition to making the filing under Item 2 above, you must attach a copy of your
83(b) Election Form to your federal tax return for the taxable year that includes the Grant
Date. Applicable state law also may require you to attach a copy of the 83(b) Election Form
to any state income tax returns that you file for that taxable year.

	5.	 	If you make an 83(b) Election and later forfeit the Award Shares, you will not be entitled to
a refund of the taxes paid with respect to the gross income you recognized under the
83(b) Election.

	6.	 	You must consult your personal tax advisor before making an 83(b) Election. You may
not rely on this information, the Company, or any of the Company’s officers, directors, or
employees for tax or legal advice regarding the Award Shares or the 83(b) Election. The
election form attached to these instructions is intended as a sample only. It must be
tailored to your circumstances and may not be relied upon without consultation with a personal
tax advisor.

SECTION 83(b) ELECTION FORM

Election Pursuant to Section 83(b) of the Internal Revenue Code to

Include Property in Gross Income in Year of Transfer

The undersigned hereby makes an election pursuant to Section 83(b) of the Internal Revenue
Code with respect to the property described below and supplies the following information in
accordance with the regulations promulgated thereunder:

1. The name, address, and taxpayer identification number of the undersigned are:

      

      

      

      -      -      

2. The property with respect to which the election is made is        shares of
Stock, par value $0.001 per share, of Halozyme Therapeutics, Inc., a Delaware corporation (the
“Company”).

3. The date on which the property was transferred was       , the date on which the
taxpayer received the property pursuant to a grant of restricted stock.

4. The taxable year to which this election relates is calendar year 20      .

5. The property is subject to restrictions in that the property is not transferable and is
subject to a substantial risk of forfeiture until the taxpayer vests in the property. The taxpayer
will vest in the property on       , if at all, in increments of 20% of the restricted
shares for each of the following events that occurs: [insert performance objectives]

6. The fair market value at the time of transfer (determined without regard to any
restrictions other than restrictions which by their terms will never lapse) of the property with
respect to which this election is being made is $    per share; with a cumulative fair
market value of $     .

7. The taxpayer did not pay any amount for the property transferred.

8. A copy of this statement was furnished to the Corporate Secretary or other designated
officer of the Company. The taxpayer rendered the services to        in
connection with the transfer of the property with respect to which this election is being made.

9. This election is made to the same effect, and with the same limitations, for purposes of
any applicable state statute corresponding to Section 83(b) of the Internal Revenue Code.

The undersigned understands that the foregoing election may not be revoked except with the
consent of the Commissioner of Internal Revenue.

	 	 	 	 	 
	Signed: _________________________________________________

	Date:
	 	 	—	 

Letter for filing §83(b) Election Form

[Date]

CERTIFIED MAIL

RETURN RECEIPT REQUESTED

***Please insert the IRS Service Center where you file your federal income tax return below.***

Internal Revenue Service Center

	 	 	 	 	 	 	 	 	 
	Re:	 	83(b) Election of [Name]
Social Security Number:
	 	 	_______________________	 

Dear Sir/Madam:

Enclosed is an election under §83(b) of the Internal Revenue Code of 1986, as amended, with
respect to certain shares of stock of Halozyme Therapeutics, Inc., a Delaware corporation, that
were transferred to me on       , 20      .

Please file this election.

Sincerely,

     

[Name]

cc: Corporate Secretary of Halozyme Therapeutics, Inc.

2

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