Document:

THIRD AMENDMENT

         THIS THIRD AMENDMENT (this "Amendment") dated as of June 23, 2000, to
the Loan Agreement referenced below, is by and among Pharmaceutical Product
Development, Inc., a North Carolina corporation (the "Borrower"), the
Subsidiaries of the Borrower identified on the signature pages hereto (the
"Guarantors") and First Union National Bank (the "Bank"). Terms used herein but
not otherwise defined herein shall have the meanings provided to such terms in
the Loan Agreement.

                               W I T N E S S E T H

         WHEREAS, a $50 million credit facility has been established in favor of
the Borrower pursuant to the terms of that Loan Agreement dated as of June 24,
1998 (as amended and modified from time to time, the "Loan Agreement") among the
Borrower, the Guarantors and the Bank;

         WHEREAS, the Borrower has requested certain modifications to Loan
Agreement;

         WHEREAS, the Bank has agreed to the modifications on the terms and
conditions set forth herein;

         NOW, THEREFORE, IN CONSIDERATION of the premises and other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties hereto agree as follows:

         1. The Loan Agreement is amended in the following respects:

         1.1 The definition of "Termination Date" in Section 1.1 of the Loan
         Agreement is amended to read as follows:

             "Termination Date" means June 30, 2001, or such later date as
             to which the Bank may agree in its sole discretion.

         1.2 Clause (a) of Section 6.6 of the Loan Agreement is amended to read
         as follows:

                  (c) guaranty obligations of the Borrower in respect of Funded
                  Debt of PPGx, Inc. in an aggregate principal amount of up to
                  $9,000,000 at any time;

         2. This Amendment shall be effective upon execution of this Amendment
by the Borrower, the Guarantors and the Bank.

         3. Except as modified hereby, all of the terms and provisions of the
Loan Agreement (including Schedules and Exhibits) shall remain in full force and
effect.

         4. The Borrower agree to pay all reasonable costs and expenses of the
Bank in connection with the preparation, execution and delivery of this
Amendment, including without limitation the reasonable fees and expenses of
Moore & Van Allen, PLLC.

         5. This Amendment may be executed in any number of counterparts, each
of which when so executed and delivered shall be deemed an original and it shall
not be necessary in making proof of this Amendment to produce or account for
more than one such counterpart.
<PAGE>

         6. This Amendment shall be deemed to be a contract made under, and for
all purposes shall be construed in accordance with, the laws of the State of
North Carolina.

                  [Remainder of Page Intentionally Left Blank]

                                       2
<PAGE>
         IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart
of this Amendment to be duly executed and delivered as of the date first above
written.

BORROWER:                           PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.,
                                    a North Carolina corporation

                                    By:  /s/  Fredric N. Eshelman
                                       ---------------------------------
                                    Name:  Fredric N. Eshelman
                                    Title:  Chief Executive Officer

GUARANTORS:                         PPD DEVELOPMENT, INC.,
                                    a Texas corporation

                                    By:  /s/  Fredric N. Eshelman
                                       ---------------------------------
                                    Name:  Fredric N. Eshelman
                                    Title:  Chief Executive Officer

BANK:                               FIRST UNION NATIONAL BANK

                                    By:  /s/ G. Mendel Lay, Jr.
                                       ---------------------------------
                                    Name:  G. Mendel Lay, Jr.
                                    Title:  Senior Vice PresidentFOURTH AMENDMENT

         THIS FOURTH AMENDMENT (this "Amendment") dated as of June 30, 2000, to
the Loan Agreement referenced below, is by and among Pharmaceutical Product
Development, Inc., a North Carolina corporation (the "Borrower"), the
Subsidiaries of the Borrower identified on the signature pages hereto (the
"Guarantors") and First Union National Bank (the "Bank"). Terms used herein but
not otherwise defined herein shall have the meanings provided to such terms in
the Loan Agreement.

                               W I T N E S S E T H

         WHEREAS, a $50 million credit facility has been established in favor of
the Borrower pursuant to the terms of that Loan Agreement dated as of June 24,
1998 (as amended and modified from time to time, the "Loan Agreement") among the
Borrower, the Guarantors and the Bank;

         WHEREAS, the Borrower has requested certain modifications to Loan
Agreement;

         WHEREAS, the Bank has agreed to the modifications on the terms and
conditions set forth herein;

         NOW, THEREFORE, IN CONSIDERATION of the premises and other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties hereto agree as follows:

         1. The definition of "Termination Date" in Section 1.1 of the Loan
         Agreement is amended to read as follows:

                  "Termination Date" means June 30, 2001, or such later date as
                  to which the Bank may agree in its sole discretion.

         2. This Amendment shall be effective upon execution of this Amendment
by the Borrower, the Guarantors and the Bank.

         3. Except as modified hereby, all of the terms and provisions of the
Loan Agreement (including Schedules and Exhibits) shall remain in full force and
effect.

         4. The Borrower agree to pay all reasonable costs and expenses of the
Bank in connection with the preparation, execution and delivery of this
Amendment, including without limitation the reasonable fees and expenses of
Moore & Van Allen, PLLC.

         5. This Amendment may be executed in any number of counterparts, each
of which when so executed and delivered shall be deemed an original and it shall
not be necessary in making proof of this Amendment to produce or account for
more than one such counterpart.

         6. This Amendment shall be deemed to be a contract made under, and for
all purposes shall be construed in accordance with, the laws of the State of
North Carolina.

                  [Remainder of Page Intentionally Left Blank]

<PAGE>
         IN WITNESS WHEREOF, each of the parties hereto has caused a counterpart
of this Amendment to be duly executed and delivered as of the date first above
written.

BORROWER:                           PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.,
                                    a North Carolina corporation

                                    By:    /s/ Fredric N. Eshelman
                                       ---------------------------------
                                    Name:  Fredric N. Eshelman
                                    Title:  Chief Executive Officer

GUARANTORS:                         PPD DEVELOPMENT, INC.,
                                    a Texas corporation

                                    By: /s/ Fredric N. Eshelman
                                       ---------------------------------
                                    Name:  Fredric N. Eshelman
                                    Title:  Chief Executive Officer

BANK:                               FIRST UNION NATIONAL BANK

                                    By:  /s/  Shannon S. Townsend
                                       ---------------------------------
                                    Name:  Shannon S. Townsend
                                    Title:  Vice PresidentExhibit 10.8

                       FIRST AMENDMENT TO CREDIT AGREEMENT
                       -----------------------------------

         This FIRST AMENDMENT (this "Amendment") dated as of February 10, 2000,
is among (a) WASTE INDUSTRIES, INC., a North Carolina corporation having its
principal place of business at 3301 Benson Drive, Suite 601, Raleigh, North
Carolina 27609 (the "Parent"), and each of the subsidiaries of the Parent (the
"Subsidiaries" and together with the Parent, the "Borrowers"), (b) BANKBOSTON,
N.A., a national banking association having its principal place of business at
100 Federal Street, Boston, Massachusetts 02110 (acting in its individual
capacity, "BKB"), and the other lending institutions listed on the signature
pages hereto (collectively, the "Banks"), (c) BANKBOSTON, N.A. as Administrative
Agent for the Banks (the "Administrative Agent"), and (d) BRANCH BANKING AND
TRUST COMPANY, as Documentation Agent for the Banks (the "Documentation Agent").

         WHEREAS, the Borrowers, the Banks, the Administrative Agent and the
Documentation Agent are parties to that certain Revolving Credit Agreement dated
as of November 9, 1999 (as amended, the "Credit Agreement");

         WHEREAS, the Parent and the Noteholders (as defined in the Credit
Agreement) are parties to certain Purchase Agreements (as defined in the Credit
Agreement);

         WHEREAS, pursuant to ss.12.1(p) of the Credit Agreement, the Parent was
required to enter into a Conforming Amendment (as defined in the Credit
Agreement) to the Purchase Agreements so as to conform certain provisions of the
Purchase Agreements to the Credit Agreement;

         WHEREAS, in connection with the execution of the Conforming Amendment,
the Borrowers have requested an amendment to ss.7.7 of the Credit Agreement.

         WHEREAS, the Administrative Agent and the Majority Banks have agreed,
subject to the satisfaction of the conditions precedent set forth herein, to
amend the Credit Agreement as set forth herein;

         NOW, THEREFORE, the Borrowers, the Administrative Agent, the Banks and
the Documentation Agent hereby agree as follows:

         ss.1. Defined Terms. Capitalized terms which are used herein without
definition and which are defined in the Credit Agreement shall have the same
meanings herein as in the Credit Agreement.

         ss.2. Amendment to Credit Agreement.

         (a) Section 7.3 of the Credit Agreement is hereby amended by adding the
following new clause (h):

                           "(h) other Investments not to exceed the sum of
                  $2,000,000 in the aggregate at any one time outstanding with
                  respect to non-hazardous solid waste collection, transfer,
                  hauling, recycling or disposal businesses, projects,
                  joint-ventures or enterprises or purchase options."
<PAGE>
                                      -2-

         (b) Section 7.7 of the Credit Agreement is hereby amended by deleting
ss.7.7 thereto in its entirety and substituting the following new ss.7.7:

                           "7.7 Debt Modification, Etc. The Borrowers will not
                  (i) amend, supplement or otherwise modify the terms of any
                  Subordinated Debt, (ii) pay, redeem or repurchase any
                  Subordinated Debt or (iii) amend, supplement or otherwise
                  modify any event of default or any negative and financial
                  covenant contained in the Noteholders' Debt (other than the
                  Conforming Amendment) without the consent of the Majority
                  Banks. Prior to any principal payment or prepayment of the
                  Noteholders' Debt, the Borrowers shall deliver to the
                  Administrative Agent a certificate setting forth in reasonable
                  detail computations evidencing the pro forma effect of the
                  contemplated payment on the Borrowers' compliance with the
                  covenants contained in ss.8 hereof."

         ss.3. Special Waiver of ss.12.1(p)(iv) of the Credit Agreement. The
Administrative Agent and the Majority Banks hereby agree that the Borrowers'
obligations under ss.12.1(p)(iv) of the Credit Agreement (delivery of Conforming
Amendment within thirty (30) days after the Closing Date) shall be waived
effective as of the date that the conditions in ss.5 hereof are satisfied.

         ss.4. Representations and Warranties. Each of the Borrowers represents
and warrants to the Administrative Agent and the Banks as follows:

         (a) The representations and warranties of the Borrowers contained in
the Credit Agreement, as amended hereby, (i) were true and correct in all
material respects when made, and (ii) continue to be true and correct in all
material respects on the date hereof, except to the extent such representations
and warranties by their terms are made solely as of a prior date.

         (b) The execution and delivery by the Borrowers of this Amendment and
the performance by the Borrowers of all of their agreements and obligations
under this Amendment and the Credit Agreement and the other Loan Documents as
amended hereby (i) are within the corporate authority of each of the Borrowers,
(ii) have been duly authorized by all necessary corporate proceedings or actions
by each of the Borrowers, (iii) do not conflict with or result in any breach or
contravention of any provision of law, statute, rule or regulation to which the
Borrowers are subject or any judgment, order, writ, injunction, license or
permit applicable to the Borrowers, and (iv) do not conflict with any provision
of the corporate charter, by-laws or any agreement or other instrument binding
upon any of the Borrowers.

         (c) This Amendment, and the Credit Agreement as amended hereby, and the
other Loan Documents to which each of the Borrowers is a party constitute the
legal, valid and binding obligations of each of the Borrowers (as the case may
be) enforceable against each such Person in accordance with their respective
terms.

         ss.5. Conditions to Effectiveness. This Amendment shall be effective
upon receipt by the Administrative Agent of the following:

         (a) any original counterpart signature (or a faxed copy thereof with
originals to follow) to this Amendment, duly executed and delivered by the
Borrowers and the Majority Banks; and
<PAGE>
                                      -3-

         (b) a copy of the duly executed Conforming Amendment, which shall be in
form and substance satisfactory to the Administrative Agent in all respects.

         ss.6. Costs and Expenses. The Borrowers acknowledge and agree that the
reasonable costs and expenses incurred by the Administrative Agent (including
attorneys' fees) in the preparation, negotiation and execution of this Amendment
and the other documents and instruments contemplated hereby are for the account
of the Borrowers as provided in ss.15 of the Credit Agreement.

         ss.7. Miscellaneous Provisions.

         (a) Except as otherwise expressly provided by this Amendment, all of
the terms, conditions and provisions of the Credit Agreement shall remain the
same. It is declared and agreed by each of the parties hereto that the Credit
Agreement, as amended hereby, shall continue in full force and effect, and that
this Amendment and the Credit Agreement shall be read and construed as one
instrument.

         (b) THIS AMENDMENT SHALL BE DEEMED TO BE A CONTACT UNDER SEAL UNDER THE
LAWS OF THE COMMONWEALTH OF MASSACHUSETTS AND SHALL FOR ALL PURPOSES BE GOVERNED
BY, AND CONSTRUED ACCORDING TO, THE LAWS OF THE COMMONWEALTH OF MASSACHUSETTS
(EXCLUDING THE LAWS APPLICABLE TO CONFLICTS OR CHOICE OF LAW).

         (c) This Amendment may be executed in any number of counterparts, but
all such counterparts shall together constitute but one instrument. In making
proof of this Amendment it shall not be necessary to produce or account for more
than one counterpart signed by each party hereto by and against which
enforcement hereof is sought.

         (d) Headings or captions used in this Amendment are for convenience of
reference only and shall not define or limit the provisions hereof.
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the date first written above.

                                     WASTE INDUSTRIES, INC.
                                     KABCO OF NORTH CAROLINA, INC.
                                     WASTE ENTERPRISES, INC.
                                     WASTE INDUSTRIES EAST, INC.
                                     NORTH MECKLENBURG SANITATION, INC.
                                     WASTE INDUSTRIES SOUTH, INC.
                                     WASTE INDUSTRIES OF GEORGIA, INC.
                                     ECO SERVICES, INC.
                                     WI-ACS, INC.
                                     DUMPSTERS, INC.
                                     RELIABLE TRASH SERVICE, INC.
                                     RAILROAD AVENUE DISPOSAL, INC.
                                     TRANS WASTE SERVICES, INC.
                                     CURB APPEAL NEW HOME SERVICES, INC.
                                     OLD KINGS ROAD SOLID WASTE, INC.
                                     WASTE INDUSTRIES OF TENNESSEE, LLC
                                     WASTE SERVICES OF DECATUR, LLC
                                     LIBERTY WASTE LENDING COMPANY, LLC
                                     WASTE INDUSTRIES OF VIRGINIA, LLC
                                     QUICK-WAY SALVAGE, INC.
                                     S&S ENTERPRISES, INC.
                                     SOUTHERN WASTE SERVICES, INC.
                                     SOUTHERN WASTE OF ALABAMA, INC.

                                     By: _______________________________________
                                     Name:
                                     Title:

                                     BANKBOSTON, N.A., individually and as
                                     Administrative Agent

                                     By: _______________________________________
                                     Name:

                                     BRANCH BANKING AND TRUST COMPANY,
                                     individually and as Documentation Agent

                                     By: _______________________________________
                                     Name:
<PAGE>

                                            COMERICA BANK

                                            By: ________________________________
                                            Name:

                                            WACHOVIA BANK, N.A.

                                            By: ________________________________
                                            Name:

                                            FIRST UNION NATIONAL BANK

                                            By: ________________________________
                                            Name:

                                            CITIZENS BANK OF MASSACHUSETTS (as
                                            successor to USTRUST)

                                            By: ________________________________
                                            Name:  Errin Siagel

                                            CENTURA BANK

                                            By:_________________________________
                                            Name:

                                            BANK AUSTRIA CREDITANSTALT
                                            CORPORATE FINANCE, INC.

                                            By: ________________________________
                                            Name:

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