Document:

exv10w6

Exhibit 10.6

AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT

     This Amendment No. 1 to Employment Agreement (this “Amendment”) is made as of
September 23, 2011, by and between RXi Pharmaceuticals Corporation, a Delaware corporation
(“Employer”), and Mark W. Schwartz, Ph.D., an individual and resident of the State of
California (“Employee”), with reference to the following facts:

     WHEREAS, Employer and Employee previously entered into an Employment Agreement, dated as of
April 13, 2011 (the “Employment Agreement”), in connection with Employee’s appointment as
Employer’s Executive Vice President and Chief Operating Officer; and

     WHEREAS, Employer and Employee wish to amend the Employment Agreement in certain respects as
provided in this Amendment.

     NOW, THEREFORE, in consideration of the foregoing and other consideration, the receipt and
sufficiency of which hereby are acknowledged, Employer and Employee hereby agree as follows:

     1. Definitions. Terms not defined in this Amendment shall have the meanings
attributed to such terms in the Employment Agreement.

     2. Amendments.

          (a) Section 4 of the Employment Agreement is hereby amended by removing therefrom the first
sentence and substituting the following:

     “Employee’s employment shall commence on the Effective Date and shall
terminate on September 23, 2013 (the “Term”), unless sooner
terminated in accordance with Section 6.”

          (b) Section 5.1 of the Employment Agreement is hereby amended and restated in its entirety to
read as follows:

     “5.1 Salary. Effective retroactive to September 7, 2011,
Employee shall be entitled to receive an annual base salary during the Term
of Three Hundred Fifty Thousand Dollars ($350,000) (hereinafter, the
“Base Salary”), payable in accordance with the usual payroll period
of Employer, as established from time to time.”

     3. Stock Options. In conjunction with and consideration of Employee’s entering into
this Amendment, the Administrator (as defined therein) under Employer’s Amended and
Restated 2007 Incentive Plan, as amended (as so amended, the “2007 Plan”), has granted
Employee as of September 7, 2011 (the “Grant Date”) an incentive stock option under the Plan to purchase up to 250,000
shares of Employer’s common stock. Such option vested and became exercisable, in full, as of
the Grant Date, and is on such other terms set forth in the Incentive Stock Option Agreement, a
copy of which is attached as Exhibit A hereto.

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     4. No Other Changes to the Employment Agreement. Except as expressly amended by this
Amendment, all of the terms of the Employment Agreement shall remain in full force and effect.

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first set
forth above.

	 	 	 	 	 	 	 

	RXI PHARMACEUTICALS CORPORATION	 	 	EMPLOYEE
	 
	By: 	 /s/ Mark J. Ahn	 	 	/s/ Mark W. Schwartz
	 	Mark J. Ahn, Ph.D., President and Chief	 	 	Mark W. Schwartz, Ph.D.
	 	Executive Officer	 	 	 	 

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EXHIBIT A

Form of Incentive Stock Option Agreement

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EXHIBIT 10.1

CONSULTING AGREEMENT

     This Consulting Agreement (the “Agreement”) is effective September 21, 2011, by and
between Centrue Financial Corporation, (the “Company”), and Thomas A. Daiber (the “Consultant”):

RECITALS:

     WHEREAS, the Company and the Consultant desire to set forth their respective rights and
obligations in connection with the certain consulting services of the Consultant;

     NOW THEREFORE, in consideration of the premises and of the mutual covenants, agreements and
understandings contained herein, the parties hereto agree as follows:

AGREEMENT:

     1. Retention. The Company agrees to retain the Consultant during the Term (as such term is
hereinafter defined in Section 4 below) and the Consultant hereby accepts such engagement by the
Company, subject to the terms and conditions hereinafter set forth herein. This Agreement
establishes the terms of the Consultant’s retention and any payment(s) to which the Consultant is
entitled during the Term. The Company and the Consultant retain the right to terminate this
Agreement for the reasons described in Section 4 below.

     2. Responsibilities and Duties. During the period from the date hereof through December 31,
2011, the Consultant will provide consulting services to the Company. The Consultant agrees that
he desires to participate in the transition to the new President and Chief Executive Officer of the
Company (the “President”) and hereby tenders his resignation as an employee and officer of the
Company and of the Company’s wholly owned subsidiary, Centrue Bank, (the “Bank”) effective as of
the end of the day on September 21, 2011. In addition, the Consultant hereby tenders his
resignation as a director of the Company and the Bank, effective as of the end of the day on
September 21, 2011. The Company hereby accepts such resignation, effective as of the end of the
day on September 21, 2011. In order to facilitate a smooth and orderly transition within Company
upon the Consultant’s termination of employment, and to assure access to the Consultant’s unique
and valuable services, Company desires to retain the services of the Consultant as a consultant for
a specified Term, as described in Section 4 below, on the terms and conditions set forth herein.
The Consultant shall perform such services as requested by the President, including, not by way of
limitation, working directly with the Capital Committee of the Company’s Board of Directors in its
capital raising efforts.

     3. Compensation/Consultant Fee. In consideration of the performance of such services by the
Consultant, the Company will pay the Consultant $15,000 per month, payable on the last day of each
month (the “Fee”). In the event that the Consultant elects COBRA continuation coverage under the
Company’s health plan, the Company shall also pay the Consultant’s COBRA premiums through December
31, 2011 or the date this Agreement terminates, if earlier. In the event this Agreement terminates
pursuant to Section 4 prior to December 31, 2011, for the month in which such termination occurs
(the “Termination Month”),

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the Company shall pay the Consultant a pro-rata portion of $15,000 determined by dividing the
number of days of the Termination Month through the termination date divided by the total number of
days in such month. The Consultant’s right to payment or the right to retain payment of any amount
payable under this Section 3 is contingent upon the Consultant’s execution of a release of claims
satisfactory to the Company.

     4. Consulting Term. The period of the Consultant’s retention by the Company under this
Agreement (the “Term”) shall commence on September 22, 2011 and terminate on December 31, 2011, or
such earlier date upon the occurrence of any of the following events:

	 	(A)	 	the death or retirement of the Consultant; or
	 
	 	(B)	 	the Consultant’s Disability. For purposes of this Agreement,
“Disability” shall mean a physical or mental condition of the Consultant that
prevents him from performing the consulting services described above as
determined by the President and the Board of Directors of the Company; or
	 
	 	(C)	 	termination of this Agreement by the Board of Directors of the
Company for “Cause,” which shall mean: (1) the Consultant engages in act(s) or
omission(s) constituting dishonesty, willful misconduct, intentional breach of
fiduciary obligation or intentional wrongdoing or malfeasance, in each case
that results in substantial harm to the business or property of the Company;
(2) the Consultant is convicted of a felony; or (3) the Consultant
substantially non-performs his assigned duties for a period of thirty (30) days
after the Company has given written notice to the Consultant of such
non-performance and its intention to terminate this Agreement because of such
non-performance.

     5. Binding Effect; Assignment. The Company may assign this Agreement to any of its affiliates
or their successors or assigns. This Agreement shall be binding upon and shall inure to the benefit
of the Company, its affiliates and their successors and assigns. This Agreement shall be binding
upon and shall inure to the benefit of the Consultant. Neither this Agreement nor any right or
interest hereunder shall be assignable or transferable by the Consultant.

     6. Miscellaneous. No provision of this Agreement may be modified, waived or discharged unless
such waiver, modification or discharge is agreed to in writing and signed by the Consultant and the
Company. No agreement or representations, oral or otherwise, express or implied, with respect to
the subject matter hereof have been made by either party, which are not expressly set forth in this
Agreement. Unless otherwise requested by the President or the Board of Directors of the Company,
the Consultant shall perform the consulting services described in this Agreement off the premises
of the Company and the Bank.

     7. Other Agreements. Effective September 21, 2011, the Employment Agreement dated June 30,
2006, as amended on December 18, 2008, between the Consultant and the Company (the “Employment
Agreement”) shall be terminated, except for those provisions that survive termination, including
but not limited to the confidentiality and non-competition

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provisions of Sections 4 and 6 of the Employment Agreement, provided that solely for purposes
of applying the restrictions contained in Section 6(a)(i) of the Employment Agreement, the
Consultant and the Company agree that the term “Restrictive Period” shall mean from the end of the
day on September 21, 2011 through December 31, 2011.

     8. Notices. All notices or other communications required or permitted hereunder shall be given
in writing and shall be deemed sufficient if delivered by hand (including by courier), mailed by
registered or certified mail, postage prepaid (return receipt requested), or sent by facsimile
transmission, as follows:

If to the Consultant:

To the address on file at the Company

If to the Company:

Centrue Financial Corporation

Attn: Board of Directors

7700 Bonhomme Avenue

St. Louis, Missouri 63105

or such other address as shall be furnished in writing by such party, and any such notice or
communication shall be effective and be deemed to have been given as of the date so delivered or,
if mailed upon receipt thereof; provided, however, that any notice or communication changing any of
the addresses set forth above shall be effective and deemed given only upon its receipt.

     9. Severability. If any provision of this Agreement, or any application thereof to any
circumstance, is invalid, in whole or in part, such provision or application shall to that extent
be severable and shall not affect other provisions or applications of this Agreement.

     10. Governing Law. This Agreement shall be construed in accordance with and governed by the
laws of the State of Illinois, excluding any choice of law rule requiring application of the law or
any other jurisdiction.

     11. Entire Agreement. Except to the extent provided in Section 7 herein, this Agreement sets
forth the entire understanding of the parties hereto with respect to the subject matter hereof and
supersedes all prior and contemporaneous agreements, written or oral, between them as to such
subject matter.

     12. Confidentiality. The Consultant acknowledges that preservation of a continuing business
relationship between the Company, the Company’s subsidiary, Centrue Bank (the “Bank”), and their
respective customers, representatives and employees is of critical importance to the continued
business success of the Company and the Bank. Pursuant to the regulations of the Board of
Governors of the Federal Reserve System, it is the active policy of the Company and the Bank to
guard as confidential certain information not available to the public and relating to the business
affairs of the Company and the Bank (“Confidential Supervisory Information”), as such term is
defined in 12 C.F.R. § 261.2(b). The Consultant

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agrees that during the term of this Agreement and at any time thereafter he will not disclose
to any person or entity any Confidential Supervisory Information that was obtained by the
Consultant in the course of his employment with the Company or the Bank and in the course of the
provision of services by the Consultant under this Agreement. The Consultant further acknowledges
that he is aware of and agrees to abide by the prohibition on the dissemination of Confidential
Supervisory Information contained in 12 C.F.R. § 261.20(g) and the Consultant further agrees not to
use the Confidential Supervisory Information for any purpose other than as provided under the
Agreement.

     13. Headings. The headings contained herein are solely for the purpose of reference, are not
part of this Agreement and shall not in any way affect the meaning or interpretation of this
Agreement.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be duly executed as of the
21st day of September, 2011.

	 	 	 	 	 
	 	CENTRUE FINANCIAL CORPORATION

 	 
	 	By:  	/s/ Dennis J. McDonnell
 	 
	 	 	Dennis J. McDonnell 	 
	 	 	Chairman of the Board of Directors 	 
	 	 	 
	 	 	                               /s/ Thomas A. Daiber
 	 
	 	 	Thomas A. Daiber, Consultant 	 
	 	 	 
	 

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