Document:

<PAGE>   1
                                                                   EXHIBIT 10.33

                               SUBLEASE AGREEMENT

This Sublease is made as of September 9, 1999, by and between Molecular Devices,
a California Corporation ("Sublessee") and Medtronic, Inc., a Minnesota
Corporation ("Sublessor").

Whereas, Sublessor entered into a Lease ("Master Lease") dated February 1, 1996,
between Principal Mutual Life Insurance Company, an Iowa Corporation, or
subsequent assigns as Lessor ("Lessor"), and whereby Lessor is leasing to
Sublessor, as Lessee, certain Premises located at 1312 Crossman Avenue,
Sunnyvale, California. A copy of the Master Lease is attached hereto as Exhibit
"A" and made a part of this Sublease. Capitalized terms not otherwise defined
herein shall have the same meanings assigned to them in the Master Lease.

1.   PREMISES

     Sublessor hereby subleases to Sublessee, and Sublessee hereby subleases
from Sublessor, for the term and upon the conditions hereinafter provided, the
Premises as described in the Master Lease. The Premises address is known as 1312
Crossman Avenue, Sunnyvale California (Tax Parcel #110-36-002-00), and shall
consist of 54,430 square feet for purposes of this Sublease.

2.   TERM

     The term of this Sublease shall commence upon the "Commencement Date",
which shall be January 1, 2000 and the Termination Date shall be April 30, 2003.

3.   EARLY POSSESSION

     Sublessor will allow Sublessee early possession of the Premises on October
15, 1999 ("Possession Date"), to construct Sublessee's improvements, and
Sublessee, as a condition to early possession, will be required to provide a
certificate of liability and builders risk insurance, and effective on the
Possession Date pursuant to Section 9 and 12 of this Sublease, pay all utility
costs and repairs and maintenance of all building electrical and mechanical
systems serving the Premises. Sublessor will continue to pay the Operating
Expense and Tax Expense until the Commencement Date of this Sublease, at which
time the Operating Expense and Tax Expense will be paid by Sublessee to
Sublessor pursuant to Section 8 of this Sublease.

4.   ACCEPTANCE OF PREMISES

     Sublessee acknowledges that the Premises contains certain existing
improvements with which the Sublessee is familiar, and Sublessee agrees that by
its act of taking possession of the Premises on the Possession Date will
constitute Sublessee's acceptance of the Premises in good condition, and except
as provided for herein, that Sublessor makes no representation or warranty of
any kind whatsoever as to the condition or repair of the Premises, except as
otherwise provided herein. Sublessee acknowledges that Sublessee is subleasing
the Premises strictly on an "as is" basis. Sublessor makes no representation or
warranty relating to the suitability of the Premises for Sublessee's intended
use, or whether the Premises are in compliance with all applicable building
codes, governmental laws, statutes, ordinances and regulations (e.g., ADA and
Title 24 statutes and laws).

<PAGE>   2
5.   BASE RENT

     Sublessee shall pay directly to Sublessor on a monthly basis "Base Rent"
as calculated using a triple net (NNN) rental rate, as follows:

<TABLE>
<CAPTION>
RENTAL PERIOD            MONTHLY BASE RENT             NNN RENTAL RATE
---------------------    --------------------          ---------------------
<S>                      <C>                           <C>
1/01/2000 - 4/30/2001    $51,708.50 per month          $0.95 NNN per s.f./mo.
5/01/2001 - 4/30/2003    $52,797.10 per month          $0.97 NNN per s.f./mo.
</TABLE>

The Base Rent shall be paid in monthly installments, in advance, on or before
the first day of each and every calendar month during the Term to Sublessor at
the Sublessor's address set forth in Section 33 or to such other party or to
such other address as Sublessor may designate from time to time by written
notice to Sublessee, without demand and without deduction or set-off upon
execution of the Sublease, Sublessee shall deposit with Sublessor the sum of
$51,708.50 which shall apply to the "Base Rent" for the first months rent,
namely, January 1, 2000 through January 31, 2000. Notwithstanding the foregoing,
the Rent shall abate hereunder to the extent Rent is abated under the Master
Lease.

6.   REIMBURSED IMPROVEMENTS

     In addition to the Base Rent, the Sublessee will pay to Sublessor on a
monthly basis "Reimbursed Improvements" of $32,658.00 per month as a
reimbursement for the improvements Sublessor has already made in the facility.
The Reimbursed Improvements shall be paid in monthly installments of
$32,658.00, in advance, on or before the first day of each and every calendar
month during the Term to Sublessor at the Sublessor's address set forth in
Section 30 or to such other party or to such other address as Sublessor may
designate from time to time by written notice to Sublessee, without demand and
without deduction or set-off. Upon execution of the Sublease, Sublessee shall
deposit with Sublessor in addition to the Base Rent, the sum of $32,658.00
which shall apply to the Reimbursed Improvements for the first month, namely
January 1, 2000 through January 31, 2000. Sublessor represents and warrants
that there are no alterations or improvements made by Sublessor to the Premises
that are or will be required to be removed or restored to the Premises upon
termination of the Master Lease. In the event that Lessor shall require the
removal of any signs, fixtures, furniture or furnishings or any improvements
made by Sublessor prior to the commencement of this Sublease, or any repair of
any damage caused by the installation or removal of such items, in accordance
with the provisions of Section 10 of the Master Lease, Sublessor shall be and
remain responsible for such removal and/or repair.

7.   SECURITY DEPOSIT

     Sublessee shall deposit with Sublessor upon execution hereof One hundred
thousand dollars and no/cents ($100,000.00) as security for Sublessee's
faithful performance of Sublessee's obligations hereunder. If Sublessee fails
to pay rent or other charges due hereunder, or otherwise defaults with respect
to any provision of this Lease, Sublessor may use, apply or retain all or any
portion of said deposit for the payment of any rent or other charge in default
of the payment of any other sum to which Sublessor may become obligated by
reason of Sublessee's default, or to compensate Sublessor for any loss or
damage which Sublessor may suffer thereby. If Sublessor so uses or applies all
or any portion of said deposit, Sublessee shall within ten (10) days after
written demand therefor deposit cash with Sublessor in an amount sufficient to
restore said deposit to the full amount. Sublessor shall not be required to
keep said security deposit separate from its general accounts. Said deposit, or
so much thereof as has not theretofore been applied by Sublessor, shall

<PAGE>   3
be returned, without payment of interest, to Sublessee (or, at Sublessor's
option, to the last assignee, if any, of Sublessee's interest hereunder) at the
expiration or early termination of the term hereof, and after Sublessee has
vacated the Premises. No trust relationship is created herein between Sublessor
and Sublessee with respect to said Security Deposit.

8.   OPERATING EXPENSES TAX EXPENSE

     In addition to Base Rent and Reimbursed Improvements set forth above,
starting with the Commencement Date the Sublessee shall pay directly to
Sublessor as additional rent all the Operating Expense and Tax Expense as
defined in and in accordance with Lessee's obligations under paragraph 6 of the
Master Lease.

9.   UTILITIES

     Starting with early possession of the Premises on October 15, 1999 pursuant
to Section 3 of this Sublease, Sublessee at Sublessee's sole cost and expense,
shall be obligated for Lessee's obligations for all utility costs and expenses
defined in and in accordance with paragraph 7 of the Master Lease.

10.  USE

     Sublessee will not use the Premises differently than what Lessee is
permitted under the Master Lease in accordance with paragraph 9 of the Master
Lease.

11.  ALTERATIONS

     Sublessee shall have the same rights and obligations regarding the
installation of any signs, fixtures or improvements to the Premises as the
Lessee under the Master Lease, and shall comply with the obligations of Lessee
under paragraph 10 of the Master Lease with respect to signs, fixtures or
improvements to the Premises by Sublessee.

12.  REPAIRS AND MAINTENANCE

     As of October 15, 1999, the Sublessor will have all building systems in
good working order and condition. Starting on October 15, 1999, Sublessee at
Sublessee's sole cost and expense, shall be obligated for Lessee's obligations
for maintaining and repairing the Premises and adjacent areas in accordance
with paragraph 11 of the Master Lease.

13.  INSURANCE

     Sublessee, at Sublessee's sole cost and expense, shall accept the
obligations of the Lessee to maintain insurance in accordance with paragraph 12
of the Master Lease. Sublessee shall maintain insurance coverage limits for
bodily injury of not less than $1,000,000 per occurrence and property damage of
not less than $2,000,000 per occurrence.

14.  LIMITATION OF LIABILITY AND INDEMNITY

14.1 Sublessor shall hold harmless, indemnify and defend Sublessee and it's
employees, agents, servants, customers, vendors, Sublessees or invitees against
all claims, demands and action or loss, liability, damage, cost and expense
resulting from injury or death to any person and damage to property caused by
the negligent act or omission of Sublessor and it's employees, agents,
servants, vendors. Sublessees or invitees while in, upon or connected in any
way with the subleased premises or the common areas during the term of this
sublease.

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14.2  Sublessee shall hold harmless, indemnify and defend Sublessor and its
employees, agents, servants, customers, vendors, Sublessees or invitees against
all claims, demands and action or loss, liability, damage, cost and expense
resulting from injury or death to any person and damage to property caused by
the negligent act or omission of Sublessee and its employees, agents, servants,
vendors, Sublessees or invitees while in, upon or connected in any way with the
subleased premises during the term of this sublease.

15.   ASSIGNMENT AND SUBLETTING

      Sublessee shall have the right to sublease all or any portion of the
leased premises during the term of this Sublease with the prior written approval
of Sublessor and Lessor in accordance with paragraph 14 of the Master Lease. In
any and all events, Sublessee agrees that it shall remain primarily liable and
obligated to perform all its obligations under the Sublease and Master Lease.
Notwithstanding the foregoing, Sublessor's consent shall not be required for any
assignment or sublease to an affiliate of Sublessee; or to any party merging
with or acquiring Sublessee, or to any party acquiring all or substantially all
of the assets of Sublessee.

16.   WAIVER OF SUBROGATION

      Sublessor hereby releases Sublessee and Sublessee releases Sublessor and
their respective officers, agents, employees and servants from any and all
claims or demands for damages, loss, expense or injury to the Premises, or to
the furnishings, fixtures and equipment, inventory or other property of, or loss
of income or possible income to, or for any additional expenses incurred by
either Sublessee or Sublessor in, about, upon or in connection with the
Premises, as the case may be, which are caused or result from perils, events or
happenings which are the subject of insurance carried by the respective parties,
in force at the time of any such loss.

17.   AD VALOREM TAXES

      Sublessee shall pay before delinquent all taxes assessed against the
personal property of the Sublessee and all taxes attributable to any leasehold
improvements made by Sublessee.

18.   SUBORDINATION

      Sublessee shall comply with the obligations of the Lessee in accordance
with paragraph 17 of the Master Lease.

19.   RIGHT OF ENTRY

      Sublessee shall comply with the obligations of Lessee under paragraph 18
of the Master Lease.
<PAGE>   5
20.  ESTOPPEL CERTIFICATES

     Sublessee agrees at any time and from time to time, upon not less than ten
(10) days prior written notice by Sublessor, to execute, acknowledge and
deliver to Sublessor or a party designated by Sublessor a statement in writing
(i) certifying that this Sublease is unmodified and in full force and effect,
or if there have been modifications, that the Sublease is in full force and
effect as modified and stating the modifications, (ii) stating whether or not
Sublessor is in default in the performance of any covenant, agreement or
condition contained in this Sublease, and, if so, specifying each such
default, and (iv) agreeing that, except for any security deposit required
herein or stated otherwise herein, Sublessee shall not prepay any rent more
than 30 days in advance. Any such statement delivered pursuant hereto may be
relied upon by any owner of the Building, any prospective purchaser of the
Building, any mortgagee or prospective mortgagee of the Building or of
Sublessor's interest, or any prospective assignee of any such mortgagee.

21.  SUBLESSEE'S DEFAULT

Any one of the following events shall constitute an Event of Default by
Sublessee:

      (i) The vacation or abandonment of the Premises by the Sublessee, and
          failing to pay rent,

     (ii) The failure of Sublessee to make payment of Base Rent, Reimbursed
          Improvements, Operating Expense, Tax Expenses or other rent or
          expense as herein provided when said payment is due,

    (iii) The failure of Sublessee to observe, perform or comply with any of the
          conditions or provisions of the Sublease for a period, unless
          otherwise noted herein, of five (5) days after written notice, or such
          reasonable time as is reasonably necessary, with Sublessor's prior
          approval.

     (iv) The Sublessee becoming the subject of any bankruptcy (including
          reorganization or arrangement proceedings pursuant to any bankruptcy
          act) or insolvency proceeding whether voluntary or involuntary.

     (v)  The Sublessee using or storing Hazardous Materials as defined in the
          Master Lease on the Premises other than as permitted by the
          provisions of paragraph 29 of the Master Lease.

22.  REMEDIES FOR SUBLESSEE'S DEFAULTS

22.1 If an Event of Default shall have occurred and be continuing, Sublessor may
at its sole option by written notice of Sublessee terminate this Sublease.
Neither the passage of time after the occurrence of the Event of Default nor
exercise by Sublessor of any other remedy with regard to such Event of Default
shall limit Sublessor's rights under this Section 22.

22.2  If an Event of Default shall have occurred and be continuing, whether or
not Sublessor elects to terminate this Sublease, Sublessor may enter upon and
repossess the Premises (said repossession being hereinafter referred to as
"Repossession") by legal means, and may remove Sublessee and all other persons
and property therefrom.

<PAGE>   6
22.3  From time to time after Repossession of the Premises, whether or not this
Sublease has been terminated, Sublessor may attempt to relet the Premises for
the account of Sublessee in the name of Sublessor or otherwise, for such term
or terms (which may be greater or less than the period which would otherwise
have constituted the balance of the Term) and for such terms (which may include
concessions or free rent) and for such uses as Sublessor, may determine, and
may collect and receive the rent therefor. Any rent received shall be applied
against Sublessee's obligations hereunder. If Sublessor elects to relet the
premises for the account of Sublessee, Sublessor agrees to exert a good faith
effort to relet the premises at the then fair market rate and on terms similar
to those in effect at the time Sublessee's possession terminated.

22.4  No termination of this Sublease pursuant to Section 22.1 and no
Repossession of the Premises pursuant to Section 22.2 or otherwise shall relieve
Sublessee of its liabilities and obligations under this Sublease, all of which
shall survive any such termination or Repossession. In the event of any such
termination or Repossession, whether or not the Premises shall have been relet,
Sublessee shall pay to Sublessor the Base Rent and other sums and charges to be
paid by Sublessee up to the time of such termination or Repossession, and
thereafter Sublessee, until the end of what would have been the Term in the
absence of such termination or Repossession, shall pay to Sublessor, as and for
liquidated and agreed current damages for Sublessee's default, the equivalent of
the amount of the Base Rent and such other sums and charges which would be
payable under this Sublease by Sublessee if this Sublease were still in effect,
less the net proceeds, if any, of any reletting effected pursuant to the
provisions of Section 22.3 after deducting all of Sublessor's expenses in
connection with such reletting, including, without limitation, all repossession
costs, brokerage and management commissions, operating expenses, and reasonable
attorneys' fees. Sublessee shall pay such current damages to Sublessor monthly
on the days on which the Base Rent would have been payable under this Sublease
if this Sublease were still in effect, and Sublessor shall be entitled to
recover the same from Sublessee on each such day. At any time after such
termination or Repossession, whether or not Sublessor shall have collected any
current damages as aforesaid, Sublessor shall be entitled to recover from
Sublessee, and Sublessee shall pay to Sublessor on demand, as and for liquidated
and agreed final damages for Sublessee's default, an amount equal to the then
present value of the excess of the Base Rent and other sums or charges reserved
under this Sublease from the day of such termination or Repossession for what
would be the then unexpired term if the same had remained in effect, over the
amount of rent Sublessee demonstrates that Sublessor could in all likelihood
actually collect for the Premises for the same period, said present value to be
arrived at on the basis of a discount of four percent (4%) per annum. Sublessor
agrees that remedies set forth in this Section 22.4 shall not be exercised in a
manner as to result in double recovery of damages incurred.

22.5  Sublessor shall be in default in the event Sublessor fails to perform any
of Sublessor's obligations herein. Sublessor shall have 30 days to cure each
default, or such additional time as is reasonably required to correct any such
default, after notice by Sublessee to Sublessor properly specifying wherein
Sublessor has failed to perform any such obligation.

<PAGE>   7

23. HOLDING OVER

      Upon the expiration of this Sublease or the earlier termination of
Sublessee's right to possession, Sublessee shall immediately vacate the
Premises, remove all of its property therefrom, and leave the Premises in the
condition required by this Sublease. Should the Sublessee continue to occupy the
Premises, or any part thereof, after the expiration or termination of the Term,
whether with or without the consent of the Sublessor, such tenancy shall be from
month to month and the monthly Base Rent and Reimbursed Improvements shall be
125% of the last month of the term thereafter.

24. PARKING

      Sublessee shall have the use of all parking spaces available within the
existing parking lot and legal Parcel in accordance with paragraph 24 of the
Master Lease.

25. CASUALTY DAMAGE

      If the Premises or any part thereof shall be damaged by fire or other
casualty, Sublessee shall have the same rights and obligations of the Lessee as
stated in paragraph 27 of the Master Lease.

26. CONDEMNATION

     If any portion of the Premises, the absence of which would be detrimental
to Sublessee's business, is taken for any public or quasi-public purpose of any
lawful government power or authority or sold to a governmental entity to prevent
such taking, Sublessee shall have the same rights and obligations as stated in
the Master Lease.

27. HAZARDOUS MATERIALS

      Sublessor hereby agrees to defend, indemnify and hold harmless Sublessee
from and against any loss, claim, liability or damage arising as the result of
any past or present existence, use, handling, storage, transportation,
manufacture, release or disposal of any Hazardous Materials in, on or under the
Property, including costs of experts and attorneys fees and costs directly or
indirectly incurred (hereinafter collectively referred to as "Loss") caused by
Sublessor's actions during the term of the Master Lease. Sublessee agrees to
defend, indemnify and hold harmless Sublessor from and against any Loss caused
by Sublessee's actions during the term of this Sublease. The foregoing
indemnification's against Loss include indemnification against all costs of
removal, response, and disposal of such Hazardous Substances and shall be
binding upon and inure to the benefit of the parties hereto and their respective
successors and assigns.

28. FINANCIAL STATEMENTS

      Within ten (10) business days of Sublessor's request Sublessee shall
deliver to Sublessor the then current Annual Report and 10K Report of Sublessee
(including publicly available financials for interim periods following the end
of the last fiscal year for which such annual statements are available.

29. QUIET ENJOYMENT

      The Sublessor agrees that Sublessee, upon paying the rentals and other
payments herein required from Sublessee, and upon Sublessee's performance of
all of the provisions, covenants and conditions of this Sublease and the Master
Lease on its part to be kept and performed, may quietly have, hold and enjoy the
Premises during the term of this Sublease.

<PAGE>   8
30.  AMERICANS WITH DISABILITIES ACT

     Sublessor makes no warranties that the building is in compliance with the
Americans with Disabilities Act (ADA).

31.  ATTORNEYS FEES

     In the event of any action or proceeding brought by either party against
the other under this sublease, the prevailing party shall be entitled to
recover for the fees of its attorneys in such action or proceeding, including
costs of appeal, if any, in such amount as the court may adjudge reasonable as
attorney's fees.

32.  NOTICES

     All notices or other communications hereunder shall be in writing and
shall be hand delivered or sent by registered or certified first-class mail,
postage prepaid, or by overnight air express service to the following addresses:

     (i)  Sublessor:     Attention: Real Estate Department
                         Medtronic Inc.
                         3850 Victoria Street North
                         Shoreview, MN 55126-2978

     (ii) Sublessee:     Attention:

                         Mr. Timothy Harkness
                         ----------------------------------

                         1311 Orleans Drive
                         ----------------------------------

                         Sunnyvale, CA 94089
                         ----------------------------------

33.  BROKERS

     Sublessor and Sublessee acknowledge that the real estate representatives
are CRESA Partners San Jose ("Broker"), acting solely as agent for Sublessee,
and CRESA Partners Minneapolis/St. Paul, acting solely as agent for Sublessor.
Sublessee shall pay the real estate commission to Broker for this transaction
according to a separate agreement between Sublessor and CRESA Partners
Minneapolis/St. Paul and shall indemnify and hold Sublessee harmless from any
and all claims for brokers' fees or commissions from Broker or CRESA Partners
Minneapolis/St. Paul and from any party claiming to be an entitled to brokers'
fees or commissions through the actions of Sublessor.

34.  MISCELLANEOUS

     (a)  This is a California contract and shall be construed according to the
laws of California.

     (b)  The captions in this Sublease are for convenience only and are not a
part of this Sublease.

     (c)  If more than one person or entity shall sign this Sublease as
Sublessee, the obligations set forth herein shall be deeded joint and several
obligations of each such party.

     (d)  Time is of the essence.

<PAGE>   9
     (f)  This Sublease shall be binding upon and inure to the benefit of the
parties hereto and, subject to the restrictions and limitations herein
contained, their respective heirs, successors and assigns.

35.  TERMS OF MASTER LEASE

     Sublessee agrees to abide by the terms of the Master Lease and to agree to
perform all obligations of Sublessor, as set forth herein. Sublessee and
Sublessor covenant and agree that they will not do anything or permit anything
to be done which would give rise to a breach of the Master Lease. Except as
inconsistent with the provisions of this Sublease, the following terms,
provisions, covenants, and conditions of the Master Lease are incorporated
herein by reference in like manner as through the same were specifically set
forth herein: 8. Late Charges, 25. Sale of the Premises,

36.  MASTER LEASE

     Sublessor agrees to maintain the Master Lease in full force and effect,
without default, for the entire term of this Sublease, and specifically agrees
to pay all Rent due under the Master Lease to the extent that failure to pay
the same would adversely affect Sublessee's use or occupancy of the Premises.
Sublessor agrees that Sublessee shall be entitled to receive all services and
repairs to the Premises to be provided by Lessor to Sublessor as tenant under
the Master Lease. To the extent reasonably possible and appropriate, Sublessor
agrees to act as a conduit to transmit any instructions or requests by
Sublessee to Lessor.

37.  LESSOR'S CONSENT

     The effectiveness of this Sublease is conditioned upon receipt of Lessor's
consent to this Sublease pursuant to paragraph 14 of the Master Lease on before
September __, 1999.

IN WITNESS WHEREOF, this Sublease is executed on the date and year first
written above.

SUBLESSOR:                              SUBLESSEE:

MEDTRONIC, INC.                         MOLECULAR DEVICES

By: /s/ Donald Hagman                    By: /s/ Tim Harkness
    -------------------------------         -------------------------------
    Donald Hagman                           Tim Harkness
    Its: Director - Real Estate             Its: VP Finance & CFO
         --------------------------              --------------------------

LANDLORD:

PRINCIPAL MUTUAL INSURANCE COMPANY

By:
   --------------------------------
          Its:
              ---------------------

<PAGE>   10

                                  [FLOOR PLAN]

MEDTRONIC ANEURX
1312 CROSSMAN AVE
SUNNYVALE, CA 94089

<PAGE>   11

                                LEASE AGREEMENT

                            BASIC LEASE INFORMATION

LEASE DATE:         February 1, 1996

LESSOR:             Principal Mutual Life Insurance Company,
                    an Iowa corporation

LESSOR'S ADDRESS:   711 High Street          c/o Tarlton Properties
                    Des Moines, IA 50309     300 Second Street #109
                                             Los Altos, CA 94022

LESSEE:             Medtronic, Inc., a Minnesota corporation

LESSEE'S ADDRESS:   7000 Central Ave. N.E.
                    Minneapolis, MN 55432

LOT:                The tax parcel on which the Building is located.

PREMISES:           Approximately 54,430 square feet as shown on Exhibit A.

PREMISES ADDRESS:   BUILDING: 1312 Crossman Ave., Sunnyvale, CA
                    TAX PARCEL # 110-36-002-00

TERM:               May 1, 1996 ("Commencement Date"), through April 30, 2003
                    Seven (7) years

BASE RENT:          Month               Rent
                    -----               ----
                    01-18               $0.59 NNN per s.f./mo
                    19-36               $0.80 NNN per s.f./mo
                    37-60               $0.95 NNN per s.f./mo
                    61-84               $0.97 NNN per s.f./mo

SECURITY DEPOSIT    $32,133.00

LESSEE'S SHARE OF OPERATING EXPENSE:    100% percent
LESSEE'S SHARE OF TAX EXPENSE:          100% percent
LESSEE'S SHARE OF UTILITY EXPENSES:     100% percent

PERMITTED USES:     Light manufacturing, storage and distribution, offices,
                    marketing of medical devices and other related legal uses.

INSURANCE AMOUNT:   Bodily injury limit of not less than $1,000,000 per
                    occurrence. Property damage limit of not less than
                    $2,000,000 per occurrence.

PARKING SPACES:     All spaces available within existing parking lot and legal
                    Parcel

EXHIBITS:           Exhibit A - Premises
                    Exhibit B - Work Letter Agreement
                    Exhibit B-1 - Work Letter Addendum
                    Exhibit C - Rules and Regulations
                    Exhibit D - Commencement Date Memorandum
                    Exhibit E - Sample From Tenant Estoppel Certificate

ADDENDA:            Addendum I: Adjustments to Rent

                                       1
<PAGE>   12
                                LEASE AGREEMENT

DATE:     THIS LEASE IS MADE AND ENTERED INTO AS OF THE LEASE DATE DEFINED ON
          PAGE 1. THE BASIC LEASE INFORMATION SET FORTH ON PAGE 1 AND THIS LEASE
          ARE AND SHALL BE CONSTRUED AS A SINGLE INSTRUMENT.

     1.   PREMISES: Lessor hereby leases to Lessee upon the terms and conditions
contained herein the Premises.

     2.   TERM AND ADJUSTMENT OF COMMENCEMENT DATE: Term of Lease to be seven
(7) years from May 1, 1996 through April 30, 2003. If Lessor cannot deliver
possession of the Premises on the Commencement Date, Lessor shall not be subject
to any liability nor shall the validity of the Lease be affected; provided the
Lease term and the obligation to pay Rent shall commence on the date possession
is tendered and the termination date shall be extended by a period of time equal
to the period computed from the Commencement Date to the date possession is
tendered. In the event that Lessor permits Lessee to occupy the Premises prior
to the Commencement Date for the purposes of constructing Tenant Improvements,
such occupancy shall be subject to all the provisions of this Lease, except rent
and non-utility expenses.

     3.   RENT: Lessee agrees to pay Lessor, without prior notice or demand, the
Base Rent described on Page 1, payable in advance at Lessor's address shown on
Page 1 on the first day of each month throughout the term of the Lease. In
addition to the Rent set forth on Page 1, Rent also includes Lessee's share of
Operating Expenses and Tax Expenses and Utilities as specified in Paragraph
6.A., 6.B., and 7. of this Lease, and the term "Rent" whenever used herein
refers to all these amounts.

     4.   SECURITY DEPOSIT: Upon Lessee's execution of this Lease, Lessee shall
deposit with Lessor as a Security Deposit for the performance by Lessee of its
obligations under this Lease the amount described on Page 1. If Lessee is in
default, Lessor may use the Security Deposit, or any portion thereof, to cure
the default or to compensate Lessor for all damage sustained by Lessor resulting
from Lessee's default. Lessee shall immediately on demand pay to Lessor a sum
equal to the portion of the Security Deposit so applied so as to maintain the
Security Deposit in the sum initially deposited with Lessor. If after the
twelfth (12th) month of the Lease Term, Lessee is not currently in default and
Lessee has not been in a monetary default throughout the first 12 months of the
lease term, Lessor shall return the Security Deposit to Lessee, less such
amounts as are reasonably necessary to remedy Lessee's defaults. Lessor shall
not be required to keep the Security Deposit separate from other funds, and,
unless otherwise required by law, Lessee shall not be entitled to interest on
the Security Deposit.

     5.   TENANT IMPROVEMENTS: Lessee shall install The Improvements ("Tenant
Improvements") on the Premises as described and in accordance with the criteria
set forth in Exhibit B, attached and incorporated herein by this reference.

     6.   EXPENSES:

          A.   OPERATING EXPENSES: In addition to the Rent set forth in
Paragraph 3, Lessee shall pay its share, which is defined on Page 1, of all
operating expenses. "Operating Expenses" are defined as the total amounts paid
or payable by the Lessor in connection with the ownership, maintenance, repair
and operation of the Premises, the Building and the Lot, or where applicable,
of the Park referred to on Page 1. These Operating Expenses may include, but
are not limited to:

               (a) Lessor's cost of non-structural repairs to and maintenance of
          the roof and exterior walls of the Building;

               (b) Lessor's cost of maintaining the outside paved area,
          landscaping and other common areas for the Park;

               (c) Lessor's annual cost of all risk and other insurance
          including earthquake endorsements for the Building and the Lot and
          rental loss insurance;

                                       2
<PAGE>   13
          (d)  Lessor's cost of modifications to the Building occasioned by any
     rules, laws or regulations effective subsequent to the commencement of the
     Lease;

          (e)  Lessor's cost of modifications to the Building occasioned by any
     rules, laws or regulations arising from Lessee's use of the Premises
     regardless of when such rules, laws or regulations became effective;

          (f)  Lessor's cost of preventative maintenance contracts including,
     but not limited to, contracts for elevator systems and heating, ventilation
     and air conditioning systems, with bi-monthly service;

          (g)  Lessor's cost of security and fire protection services for the
     Project, if in Lessor's sole discretion such services are provided; and

          (h)  As compensation to Lessor for accounting and management services
     rendered, an additional amount equal to ten percent (10%) of the sum of (i)
     the total cost and expenses described in Paragraphs 6.A. above and 6.B.
     below, and (ii) all common area utility costs for the Project.

          (i)  "Operating Expenses" shall not include:

               (1)  Costs of electrical, heating, cooling and combined utility
                services to the extent that such services are separately metered
                to individual tenants and paid by them.

               (2)  Costs of obtaining and enforcing Leases.

               (3)  Costs incurred in connection with the original construction
                of the Building or in connection with any major change to the
                Building, such as adding or deleting floors.

               (4)  Costs arising from latent defects in the Base Building, or
                shell, or core of the Building or improvements installed by
                Landlord or repair thereof.

               (5)  Expenses directly resulting from the gross negligence of
                Landlord, its agents, servants or employees or another tenant.

     B.  TAX EXPENSES: In addition to the Rent set forth in Paragraph 3, Lessee
shall pay its share, which is defined on Page 1, of all real property taxes
applicable to the land and improvements included within the Lot. The term "Tax
Expense" includes any form of tax and assessment (general, special, ordinary or
extraordinary), commercial rental tax, payments under any improvement bond or
bonds, license, rental tax, transaction tax, levy, or penalty imposed by
authority having the direct or indirect power of tax (including any city,
county, state or federal government, or any school, agricultural, lighting,
drainage or other improvement district thereof) as against any legal or
equitable interest of Lessor in the Premises, Lot or Park, as against Lessor's
right to rent or other income therefrom, or as against Lessor's business of
leasing the Premises or the occupancy of Lessee or any other tax, fee, or
excise, however described, other than inheritance or estate taxes, including any
value added tax, or any tax imposed in substitution, partially or totally, of
any tax previously included within the definition of real property taxes, or any
additional tax the nature of which was previously included within the definition
of real property taxes, or any additional tax the nature of which was previously
included within the definition of real property tax. Real Estate Taxes shall not
include: (a) Income Taxes; (b) Transfer and franchise taxes; (c) "Other Taxes"
imposed directly by Landlord, unless common to NET leases in local market.

     C.  PAYMENT OF EXPENSES: Lessor shall estimate the Operating Expense and
Tax Expense for the calendar year in which the Lease commences. Commencing on
the Commencement Date, one-twelfth (1/12th) of this estimate shall be paid by
Lessee to Lessor on the first day of each month of the remaining months of the
calendar year. Thereafter, Lessor may estimate such expenses as of the beginning
of each calendar year and require Lessee to pay one-twelfth (1/12th) of such
estimated amount as additional Rent hereunder on the first day of each month.
Not later than March 31 of the following calendar year, or as soon thereafter as
reasonably possible, including the year following the year in which this Lease
terminates, Lessor shall endeavor to furnish Lessee with a true and correct
accounting of actual Operating Expenses and Tax Expenses, and within thirty (30)
days of Lessor's delivery of such accounting, Lessee shall pay to Lessor, the
amount of any underpayment. Notwithstanding the foregoing, failure by Lessor to
give such accounting by such date shall not constitute a waiver of

                                       3

<PAGE>   14
Lessor of its right to collect Lessee's share of any underpayment. Lessor shall
credit the amount of any overpayment by Lessee toward the next estimated monthly
installment(s) falling due, or where the term of the Lease has expired, refund
the amount of overpayment to Lessee.

     7.   UTILITIES: Lessee shall pay the cost of all water, sewer use and
connection fees, gas, heat, electricity, telephone and other utilities billed
or metered separately to Lessee. For utility fees or use charges that are not
billed separately to Lessee, Lessee shall pay the amount which is attributable
to Lessee's use of the Premises. In addition, Lessee shall within fifteen (15)
days after receiving a bill from Lessor pay Lessor its share, which is
described on Page 1, of any common area utility costs.

     8.   LATE CHARGES: Lessee acknowledges that late payment by Lessee to
Lessor of Rent, Lessee's share of Operating Expenses, Tax Expenses, utility
costs or other sums due hereunder, will cause Lessor to incur costs not
contemplated by this Lease and the exact amount of such costs are extremely
difficult and impracticable to fix. Such costs, include without limitation,
processing and accounting charges, and late charges that may be imposed on
Lessor by the terms of any note secured by any encumbrance against the Premises.
Therefore, if any installment of Rent or other sums due from Lessee is not
received by Lessor shall pay to Lessor a sum equal to ten percent (10%) of such
overdue amount as a late charge. The parties agree that this late charge
represents a fair and reasonable estimate of the costs that Lessor will incur by
reason of late payment by Lessee. Acceptance of any late charge shall not
constitute a waiver of Lessee's default with respect to the overdue amount, nor
prevent Lessor from exercising any of the other rights and remedies available to
Lessor.

     9.   USE OF PREMISES: The Premises are to be used for the uses stated on
Page 1 and for no other purposes without Lessor's prior written consent.

          Lessee shall not do or permit anything to be done in or about the
Premises nor keep or bring anything therein which will in any way increase the
existing rate of or affect any policy of fire or other insurance upon the
Building or any of its contents,or cause a cancellation of any insurance
policy. Lessee shall not do or permit anything to be done in or about the
Premises which will in any way obstruct or interfere with the rights of other
tenants or occupants of the Building or other buildings in the Project or
injure or annoy other tenants or sue or allow the Premises to be used for any
improper, immoral, unlawful or objectionable purpose, nor shall Lessee cause,
maintain or permit any nuisance in, on or about the Premises. Lessee shall not
damage or deface or otherwise commit or suffer to be committed any waste in or
upon the Premises. Lessee shall honor the terms of all recorded covenants,
conditions and restrictions relating to the property on which the Premises are
located. Lessee shall honor the rules and regulations attached to and made a
part of this Lease and any other reasonable regulations of the Lessor related
to parking and the operation of the Building.

     10.  ALTERATIONS AND ADDITIONS: Lessee shall not install any signs,
fixtures or improvements to the Premises without the prior written consent of
Lessor. Lessee shall keep the Premises and the property on which the Premises
are situated free from any liens arising out of any work performed, materials
furnished or obligations incurred by or on behalf of Lessee. As a condition to
Lessor's consent to the installation of any fixtures or improvements, Lessor
may require Lessee to post a completion bond for up to 150% of the cost of the
work. Upon termination of this Lease, Lessee shall remove any improvements made
by Lessee, and repair any damage caused by the installation or removal of such
signs, fixtures, furniture, furnishings and improvements and leave Premises in
as good condition as they were in at the time of the commencement of this
Lease, excepting for reasonable wear and tear. Notwithstanding the provisions
of Section 10, Tenant shall not be required to cause any lien or encumbrance to
be removed and satisfied provided Tenant shall bond against the same within
fifteen (15) days after receipt of written request by Landlord.

     11.  REPAIRS AND MAINTENANCE: Lessee shall, at Lessee's sole cost and
expense, maintain the Premises and adjacent areas in good, clean and safe
condition and repair

                                       4
<PAGE>   15
to the satisfaction of the Lessor any damage caused by Lessee or its employees,
agents, invitees, licensees or contractors. Without limiting the generality of
the foregoing, and within the interior of space, Lessee shall be solely
responsible for maintaining and repairing all plumbing, electrical wiring and
equipment, lighting, and interior walls. Lessor may repair the heating,
ventilation and air conditioning systems as deemed necessary by Lessor and
Lessee shall pay the cost of such repairs.

     Except for repairs rendered necessary by the negligence of Lessee, its
agents, customers, employees and invitees, Lessor agrees, at Lessor's sole
cost and expense, to keep in good repair the structural portions of the roof,
foundations and exterior walls of the Premises (exclusive of glass and exterior
doors), and underground utility and sewer pipes outside the exterior walls of
the Building.

     Except for normal maintenance and repair of the items outlined above,
Lessee shall have no right of access to or install any device on the roof of
the Building nor make any penetrations of the roof of the Building without the
express prior written consent of Lessor.

     12.  INSURANCE. Lessee shall at all times during the term of this Lease,
and at its sole cost and expense, maintain workers compensation insurance and
comprehensive general liability insurance against liability for bodily injury
and property damage with liability limits as set forth on Page 1 with such
insurance naming Lessor and Owner as an additional insured and including such
endorsements as may be required by Lessor. In no event shall the limits of said
policy or policies be considered as limiting the liability of Lessee under this
Lease. Landlord shall carry insurance against the loss by fire and the hazards
covered by All-Risk insurance coverage to 90% of the replacement costs of the
building, leasehold improvements, Landlord's personal property and any land
improvements.

     All insurance shall be with companies licensed to do business with the
Insurance Commissioner of the State of California. Upon written request, Tenant
shall provide to Landlord a statement of insurance. Tenant shall have the right
to self-insure (with Landlord's written approval not to be unreasonably
withheld) against any and all perils and/or liabilities against which it would
otherwise be required to insure.

     13.  LIMITATION OF LIABILITY AND INDEMNITY: Except for damage resulting
from the active negligence or willful misconduct of Lessor or its authorized
representatives, Lessor agrees to save and hold harmless and indemnify Lessor
from and against all liabilities, charges and expenses (including reasonable
attorneys' fees, costs of court and expenses necessary in the prosecution or
defense of any litigation) by reason of injury to person or property, from
whatever cause, while in or on the Premises, or in any way connected with the
Premises or with the improvements or personal property therein, including any
liability for injury to person or property of Lessee, its agents or employees or
third party persons.

     Except for damage resulting from the active negligence of Lessor or its
authorized representatives, Lessor shall not be liable to Lessee for any damage
to Lessee or Lessee's property, for any injury to or less of Lessee's business
or for any damage or injury to any person from any cause.

     14.  ASSIGNMENT AND SUBLEASING: Lessee shall not assign or transfer this
Lease nor sublet all or any portion of the Premises without the written consent
of Lessor, which shall not be unreasonably withheld. If Lessee seeks to sublet
or assign all or any portion of the Premises, a copy of the proposed sublease
or assignment agreement and all agreements collateral thereto, shall be
delivered to Lessor at least thirty (30) days prior to the commencement of the
sublease or assignment (the "Proposed Effective Date"). Each permitted assignee
or sublessee shall assume and be deemed to assume this Lease and shall be and
remain liable jointly and severally with Lessee for payment of Rent and for the
due performance of, and compliance with all the terms, covenants, conditions
and agreements herein contained on Lessee's part to be performed or complied
with, for the term of this Lease. In the event of any sublease or assignment of
all or any portion of the Premises where the Rent reserved in the sublease or

                                       5

<PAGE>   16
assignment exceeds the Rent or pro rata portion of the Rent (including all costs
associated with such sublease or assignment), as the case may be, for such space
reserved in the Lease, Lessee shall pay the Lessor monthly, as additional Rent,
at the same time as the monthly installments of Rent hereunder, one-half (1/2)
of the excess of the Rent reserved in the sublease over the Rent reserved in
this Lease applicable to the sublease space. Notwithstanding the provisions of
Section 14, nothing contained herein shall limit Tenant's rights to assign or
sublet the Premises to any subsidiary of Tenant's or any subsidiary of such
subsidiary without Landlord's consent.

     15. Subrogation: Subject to the approval of their respective insurers,
Lessor and Lessee hereby mutually waive their respective rights of recovery
against each other from any insured loss. Each party shall obtain any special
endorsements, if required by their insurer, to evidence compliance with the
aforementioned waiver.

     16. Ad Valorem Taxes: Lessee shall pay before delinquent all taxes
assessed against the personal property of the Lessee and all taxes attributable
to any leasehold improvements made by Lessee.

     17. Subordination: Lessee shall, upon written request of the Lessor,
execute any is instrument necessary or desirable to subordinate this Lease and
all of its rights contained hereunder to any and all encumbrances now or
hereafter in force against the Lot and the Building.

        In the event any proceedings are brought for foreclosure or in the
event of the exercise of the power of sale under any deed of trust made by
Lessor covering the Premises or a deed in lieu of foreclosure thereunder,
Lessee shall attorn to the purchaser upon any such foreclosure or sale and
recognize as the Lessor under this Lease any such purchaser or such transferee
who acquires the Premises by deed in lieu of foreclosure.

        Landlord shall cause any Mortgagee to agree in writing that so long as
Tenant is not then in default under the terms of this Lease, in the event of a
foreclosure under any mortgage or deed of trust affecting the Premises, or
conveyance by assignment in lieu of foreclosure or by deed in lieu of
foreclosure, will not disturb the rights of Tenant under the terms of this
Lease. In which event, the Lease shall continue in full force and effect and
Tenant shall attorn to the new Landlord hereunder upon the same terms and
conditions contained herein.

     18. Right of Entry: Lessee grants Lessor or its agents the right to enter
the Premises at all reasonable times for purposes of inspection, exhibition,
repair and alteration. Lessor shall at all times have and retain a key with
which to unlock all the doors in, upon and about the Premises, excluding
Lessee's vaults and safes, and Lessor shall have the right to use any and all
means Lessor deems necessary to enter the Premises in an emergency. Lessor
shall also have the right to place "for rent" and/or "for sale" signs on the
outside of the Premises. Lessee hereby waives any claim from damages or for any
injury or inconvenience to or interference with Lessee's business, or any other
loss occasioned thereby except for any claim for any of the foregoing arising
out of the negligent acts or omissions of Lessor or its authorized
representatives.

     19. Estoppel Certificate: Lessee shall execute and deliver to Lessor, upon
not less than fifteen (15) business days prior written notice, a statement in
writing certifying that this Lease is unmodified and in full force and effect
(or, if modified, stating the nature of such modification) and the date to
which the Rent and other charges are paid in advance, if any, and acknowledging
that there are not, to Lessee's knowledge, any uncured defaults on the part of
Lessor hereunder or specifying such defaults as are claimed. Any such statement
may be conclusively relied upon by any prospective purchaser or encumbrancer of
the Premises. Lessee's failure to deliver such statement within such time shall
be conclusive upon the Lessee that (1) this Lease is in full force and effect,
without modification except as may be represented by Lessor; (2) there are no
uncured defaults in the Lessor's performance; and (3) not more than one month's
rent has been paid in advance.

     20. Lessee's Default: The occurrence of any one or more of the following
events shall constitute a default and breach of this Lease by Lessee:

                                       6
<PAGE>   17
               (a) The vacation or abandonment of the Premises by the Lessee,
          and failing to pay rent.

               (b) The failure by Lessee to make any payment of Rent or any
          other payment required hereunder the date said payment is due.

               (c) The failure of Lessee to observe, perform or comply with any
          of the conditions or provisions of this Lease for a period, unless
          otherwise noted herein, of ten (10) days after written notice, or such
          reasonable time as is reasonably necessary, with Landlord's prior
          written approval.

               (d) The Lessee becoming the subject of any bankruptcy (including
          reorganization or arrangement proceedings pursuant to any bankruptcy
          act) or insolvency proceeding whether voluntary or involuntary.

               (e) The Lessee using or storing Hazardous Materials on the
          Premises other than as permitted by the provisions of Paragraph 29
          below.

     21. Remedies for Lessee's Default: In the event of Lessee's default or
breach of the Lease, Lessor may terminate Lessee's right to possession of the
Premises by any lawful means in which case this Lease shall terminate and
Lessee shall immediately surrender possession of the Premises to Lessor. In
addition, the Lessor shall have the immediate right of re-entry, and if this
right of re-entry is exercised following abandonment of the Premises by Lessee,
Lessor may consider any personal property belonging to Lessee and left on the
Premises to also have been abandoned, except Medtronic products.

          If Lessee breaches this Lease and abandons the property before the
end of the term, or if Lessee's right to possession is terminated by Lessor
because of a breach of the Lease, then in either such case, Lessor may recover
from Lessee all damages suffered by Lessor as a result of Lessee's failure to
perform its obligations hereunder, including, but not restricted to, the worth
at the time of the award (computed in accordance with Paragraph (3) of
Subdivision (a) of Section 1951.2 of the California Civil Code) of the amount
by which the Rent then unpaid hereunder for the balance of the Lease term
exceeds the amount of such loss of Rent for the same period which the Lessee
proves could be reasonably avoided by Lessor and in such case, Lessor prior to
the award, may relet the Premises for the purpose of mitigating damages
suffered by Lessor because of Lessee's failure to perform its obligations
hereunder; provided, however, that even though Lessee has abandoned the
Premises following such breach, this Lease shall nevertheless continue in full
force and effect for as long as the Lessor does not terminate Lessee's right of
possession, and until such termination, Lessor may enforce all its rights and
remedies under this Lease, including the right to recover the Rent from Lessee
as it becomes due hereunder. The "worth at the time of the award" within the
meaning of Subparagraphs (a)(1) and (a)(2) of Section 1951.2 of the California
Civil Code shall be computed by allowing interest at the rate of ten percent
(10%) per annum.

          Landlord agrees that remedies set forth in Section 21 shall not be
exercised in a manner as to result in double recovery of damages incurred. If
Landlord elects to relet the Premises for the account of Tenant, Landlord
agrees to exert good faith effort to relet the Premises at the then fair market
rate and on terms similar to those in effect at the time Tenant's possession
terminated.

          The foregoing remedies are not exclusive; they are cumulative in
addition to any remedies now or later allowed by law or to any equitable
remedies Lessor may have, and to any remedies Lessor may have under bankruptcy
laws or laws affecting creditor's rights generally.

          The waiver by Lessor of any breach of any term of this Lease shall
not be deemed a waiver of such term or of any subsequent breach thereof.

     22. Holding Over: If Lessee holds possession of the Premises after the
term of this Lease with Lessor's consent, Lessee shall become a tenant from
month to month upon the terms specified at a monthly Rent of 125% of the Rent
due on the last month of the

                                       7

<PAGE>   18

Lease term, payable in advance on or before the first day of each month. All
options, if any, granted under the terms of this Lease shall be deemed
terminated and be of no effect during said month to month tenancy. Lessee shall
continue in possession until such tenancy shall be terminated by either Lessor
or Lessee giving written notice of termination to the other party at least
thirty (30) days prior to the effective date of termination.

      23. Lessor's Default: Lessee agrees to give any holder of a deed of trust
encumbering the Premises ("Trust Deed Holders"), by certified mail, a copy of
any notice of default served upon the Lessor by Lessee, provided that prior to
such notice Lessee has been notified in writing (by way of Notice of Assignment
of Rents and Leases, or otherwise) of the address of such Trust Deed Holder.
Lessee further agrees that if Lessor shall have failed to cure such default
within the time, if any, provided for in this Lease, then the Trust Deed Holders
shall have an additional thirty (30) days within which to cure such default or
if such default cannot be cured within that time, then such additional time as
may be necessary, if within such thirty (30) days, the Trust Deed Holder has
commenced and is diligently pursuing the remedies necessary to cure such default
(including but not limited to commencement of foreclosure proceedings, if
necessary to effect such cure), in which event this Lease shall not be
terminated while such remedies are being so diligently pursued. If default is
not cured as herein defined, and such default causes a material business
interruption to Lessee, Tenant shall have the right to abate rent until such
default is cured.

      24. Parking: Lessee shall have the use of the number of undesignated
parking spaces set forth on Page 1. Lessor shall exercise its best efforts to
insure that such spaces are available to Lessee for its use, but Lessor shall
not be required to enforce Lessee's right to use the same.

      25. Sale of Premises: In the event of any sale of the Premises by Lessor,
Lessor shall be and is hereby released from its obligation to perform under this
Lease; and the purchaser, at such sale or any subsequent sale of the Premises
shall be deemed, without any further agreement between the parties or their
successors in interest or between the parties and any such purchaser, to have
assumed and agreed to carry out any and all of the covenants and obligations of
the Lessor under this Lease. Nothing herein shall limit Tenant's rights to have
a default cured by Landlord or owner(s) in possession at the time the default
occurred.

      26. Waiver: No delay or omission in the exercise of any right or remedy of
Lessor on any default by Lessee shall impair such a right of remedy or be
construed as a waiver.

          The subsequent acceptance of Rent by Lessor after breach by Lessee of
any covenant or term of this Lease shall not be deemed a waiver of such breach,
other than a waiver of timely payment for the particular Rent payment involved,
and shall not prevent Lessor from maintaining an unlawful detainer or other
action based on such breach.

          No payment by Lessee or receipt by Lessor of a lesser amount than the
monthly Rent and other sums due hereunder shall be deemed to be other than on
account of the earliest Rent or other sums due, nor shall any endorsement or
statement on any check or accompanying any check or payment be deemed an accord
and satisfaction; and Lessor may accept such check or payment without prejudice
to Lessor's right to recover the balance of such Rent or other sum or pursue any
other remedy provided in this Lease.

      27. Casualty Damage: If the Premises or any part thereof shall be damaged
by fire or other casualty, Lessee shall give prompt written notice thereof to
Lessor. In case the Building shall be so damaged by fire or other casualty that
substantial alteration or reconstruction of the Building shall, in Lessor's sole
opinion, be required (whether or not the Premises shall have been damaged by
such fire or other casualty), Lessor may, at its option, terminate this Lease by
notifying Lessee in writing of such termination within sixty (60) days after the
date of such damage, in which event the Rent shall be

                                       8
<PAGE>   19
abated as of the date or such damage. If Lessor does not elect to terminate
this Lease, Lessor shall within ninety (90) days after the date of such damage
commence to repair and restore the Building and shall proceed with reasonable
diligence to restore the Building (except that Lessor shall not be responsible
for delays outside its control) to substantially the same condition in which it
was immediately prior to the happening of the casualty, except that Lessor
shall not be required to rebuild, repair or replace any part of Lessee's
furniture, furnishings or fixtures and equipment removable by Lessee or any
improvements installed by Lessee under the provisions of this Lease. Lessor
shall not in any event be required to spend for such work an amount in excess
of the insurance proceeds actually received by Lessor as a result of the fire
or other casualty. Lessor shall not be liable for any inconvenience or
annoyance to Lessee, injury to the business of Lessee, loss of use of any part
of the Premises by the Lessee or loss of Lessee's personal property resulting
in any way from such damage or the repair thereof, except that, subject to the
provisions of the next sentence, Lessor shall allow Lessee a fair diminution of
Rent during the time and to the extent the Premises are unfit for occupancy. If
the Premises or any other portion of the Building be damaged by fire or other
casualty resulting from the fault or negligence of Lessee or any of Lessee's
agents, employees, or invitees, the Rent shall not be diminished during the
repair of such damage and Lessee shall be liable to Lessor for the cost and
expense of the repair and restoration of the Building caused thereby to the
extent such cost and expense is not covered by insurance proceeds.

     In the event of a conflict between a general provision of law and a
specific term or condition of this Lease, the specific term or condition of
this Lease shall control.

     28. CONDEMNATION: If any portion of the Premises, the absence of which
would be detrimental to Tenant's business, is taken for any public or
quasi-public purpose of any lawful government power or authority or sold to a
governmental entity to prevent such taking, the Lessee or the Lessor may
terminate this Lease as of the date when physical possession of the Premises is
taken by the taking authority. Lessee shall not because of such taking assert
any claim against the Lessor or the taking authority for any compensation
because of such taking, and Lessor shall be entitled to receive the entire
amount of any award without deduction for any estate of interest or interest of
Lessee. If a substantial portion of the Building or the Lot is so taken, Lessor
at its option may terminate this Lease. If Lessor does not elect to terminate
this Lease, Lessor shall, if necessary, promptly proceed to restore the Premises
or the Building to substantially its same condition prior to such partial
taking, allowing for the reasonable effects of such taking, and a proportionate
allowance shall be made to Lessee for the Rent corresponding to the time during
which, and to the part of the Premises of which, Lessee is deprived on account
of such taking and restoration. Lessor shall not be required to spend funds for
restoration in excess of the amount received by Lessor as compensation awarded.

     29. HAZARDOUS MATERIALS: Subject to the remaining provisions of this
paragraph, Lessee shall be entitled to use and store only those Hazardous
Materials (defined below), that are necessary for Lessee's business, provided
that such usage and storage is in full compliance with all applicable local,
state and federal statutes, orders, ordinances, rules and regulations (as
interpreted by judicial and administrative decisions). Lessor shall have the
right at all times during the term of this Lease to (i) inspect the Premises,
(ii) conduct tests and investigations to determine whether Lessee is in
compliance with the provisions of this paragraph, and (iii) request lists of all
Hazardous Materials used, stored or located on the Premises; the cost of all
such inspections, tests and investigations to be borne by Lessee, if Lessor
reasonably believes they are necessary. Lessee shall give to Lessor immediate
verbal and follow-up written notice of any spills, releases or discharges of
Hazardous Materials on the Premises, or in any common areas or parking lots (if
not considered part of the Premises), caused by the acts or omissions of Lessee,
or its agents, employees, representatives, invitees, licensees, subtenants,
customers or contractors. Lessee covenants to investigate, clean up and
otherwise remediate any spill, release or discharge of Hazardous Materials
caused by the acts or omissions of Lessee, or its agents, employees,
representatives, invitees, licensees, subtenants, customers or contractors at
Lessee's cost and expense; such investigation, clean up and remediation to be
performed after Lessee has obtained

                                       9

<PAGE>   20
Lessor's written consent, which shall not be unreasonably withheld; provided,
however, that Lessee shall be entitled to respond immediately to an emergency
without first obtaining Lessor's written consent. Lessee shall indemnify, defend
and hold Lessor harmless from and against any and all claims, judgments,
damages, penalties, fines, liabilities, losses, suits, administrative
proceedings and costs (including, but not limited to, attorneys' and consultant
fees) arising from or related to the use, presence, transportation, storage,
disposal, spill, release or discharge of Hazardous Materials on or about the
Premises cause by the acts or omissions of Lessee, its agents, employees,
representatives, invitees, licensees, subtenants, customers or contractors.
Lessee shall not be entitled to install any tanks under, on or about the
Premises for the storage of Hazardous Materials without the express written
consent of Lessor, which may be given or withheld in Lessor's sole discretion.
As used herein, the term Hazardous Materials shall mean (i) any hazardous or
toxic wastes, materials or substances, and other pollutants or contaminants,
which are or become regulated by all applicable local, state and federal laws;
(ii) petroleum; (iii) asbestos; (iv) polychlorinated biphenyls; and (v)
radioactive materials. The provisions of this paragraph shall survive the
termination of this Lease.

          Landlord acknowledges that to the best of his current actual
knowledge, without due inquiry, and as disclosed in the Closure Report dated
March 1, 2995 by Clayton Environmental Consultants and a Phase One Report Draft
dated January 26, 1996 by Dames and Moore and with exception of issues raised in
the Asbestos report computed for tenant by tenant's consultant, there is no
contamination on the site caused by the use of Hazardous Materials. Subject to
Tenant's early occupancy provision in Section 2, and from the date Tenant
commences construction of Tenant Improvements, Landlord hereby agrees to defend,
indemnify and hold harmless Tenant from and against any loss, claim, liability
or damage arising as the result of any prior existence, use, handling, storage,
transportation, manufacture, release or disposal of any Hazardous Materials, in,
on or under the Property, including costs of experts and attorney's fees and
costs directly or indirectly incurred (hereinafter collectively referred to as
"Loss"). The foregoing indemnification against Loss includes indemnification
against all costs of removal, response and disposal of such Hazardous Materials
and shall be binding upon and inure to the benefit of the parties hereto and
their respective successors and assigns.

     30.  FINANCIAL STATEMENTS: Within fifteen (15) business days of Lessor's
request Lessee shall deliver to Lessor the then current Annual Report and 10K
Report of Lessee (including financials for interim periods following the end of
the last fiscal year for which such annual statements are available).

     31.  GENERAL PROVISIONS:

               (i)   TIME. Time is of the essence in this Lease and with respect
          to each and all of its provisions in which performance is a factor.

               (ii)  SUCCESSORS AND ASSIGNS. The covenants and conditions herein
          contained, subject to the provisions as to assignment, apply to and
          bind the heirs, successors, executors, administrators and assigns of
          the parties hereto.

               (iii) RECORDATION. Lessee shall not record this Lease or a short
          form memorandum hereof without the prior written consent of the
          Lessor.

               (iv)  LESSOR'S PERSONAL LIABILITY. The liability of Lessor
          (which, for purposes of this Lease, shall include Lessor and the owner
          of the Building if other than the Lessor) to Lessee for any default by
          Lessor under the terms of this Lease shall be limited to the actual
          interest of Lessor and its present or future partners in the Building
          and Lessee agrees to look solely to Lessor's or Lessor's present or
          future partners' actual interest in the Building for the recovery of
          any judgment against Lessor, it being intended that Lessor shall not
          be personally liable for any judgment or deficiency. The liability of
          Lessor under this Lease is limited to its actual period of ownership
          of title to the Building, and Lessor shall be released from liability
          upon transfer of title to the Building,

                                       10
<PAGE>   21
               (v)  SEPARABILITY. Any provisions of this Lease which shall prove
          to be invalid, void or illegal shall in no way affect, impair or
          invalidate any other provisions hereof and such other provision shall
          remain in full force and effect.

               (vi) CHOICE OF LAW. This Lease shall be governed by the laws of
          the State of California.

               (vii) ATTORNEYS' FEES. In the event any legal action is brought
          to enforce or interpret the provisions of this Lease, the prevailing
          party therein shall be entered to recover all costs and expenses
          including reasonable attorneys' fees.

               (viii) This Lease supersedes any prior agreements and contains
          the entire agreement of the parties on matters covered. No other
          agreement, statement or promise made by any party that is not in
          writing and signed by all parties to this Lease shall be binding.

               (ix) WARRANTY OF AUTHORITY. Each person executing this agreement
          on behalf of a party represents and warrants that (1) such person is
          duly and validly authorized to do so on behalf of the entity it
          purports to so bind, and (2) if such party is a partnership,
          corporation or trustee, that such partnership, corporation or trustee
          has full right and authority to enter into this Lease and perform all
          of its obligations hereunder.

               (x) NOTICES. All notices and demands required or permitted to be
          sent to the Lessor or Lessee shall be in writing and shall be sent by
          United States mail, postage prepaid, certified or by personal delivery
          or by overnight courier, addressed to Lessor c/o Tarlton Properties
          Inc., (Property Manager) 300 Second Street, Suite 109, Los Altos, CA
          94022, or to Lessee at the Premises, with a copy to: Medtronic, Inc.,
          7000 Central Ave. N.E., Minneapolis, MN 55432, Attn: Corp. Real
          Estate, or to such other place as such party may designate in a notice
          to the other party given as provided herein. Notice shall be deemed
          given upon the earlier of actual receipt or the third day following
          deposit in the United States mail.

               (xi) INTERLINEATION. The use of underlining or strikeouts
          (strikeouts) within the Lease is for reference purposes only. No other
          meaning or emphasis is intended by this use, nor should any be
          inferred.

     32.  BLANKET ENCUMBRANCE: Lessee is aware of the fact that the Lot may be
subject to a deed of trust, mortgage or other lien known as a "Blanket
Encumbrance"). According to California law, Lessee could lose its interest
through foreclosure of the Blanket Encumbrance or other legal process even
though Lessee is not delinquent in Lessee's payments or other obligations under
the Lease.

     33.  QUIET ENJOYMENT: The Landlord agrees that Tenant, upon paying the
rentals and other payments herein required from Tenant, and upon Tenant's
performance of all of the provisions, covenants and conditions of this Lease on
its part to be kept and performed, may quietly have, hold and enjoy the Premises
during the term of this Lease.

     34.  OPTION TO EXTEND: Lessee shall have one (1) three (3) year option to
extend said Lease. Lessee shall provide no less than six (6) months and no more
than twelve (12) months prior written notice of its intention to extend this
Lease. The rent for the option period shall be 100% of the then fair market
value, arbitrated if necessary, for comparable facilities and comparable
improvements.

     IN WITNESS WHEREOF, this Lease is executed on the date and year first
written above.

                                       11
<PAGE>   22
LESSEE:

MEDTRONIC, INC., A MINNESOTA CORPORATION

By:  /s/ [ILLEGIBLE]
     ------------------------------------

Its: Vice President of Corporate Services

LESSOR:

PRINCIPAL MUTUAL LIFE INSURANCE COMPANY
AN IOWA CORPORATION

By:  /s/ PAT G. HALTER
     ------------------------------------

Its: Pat G. Halter
     Director
     Commercial Real Estate

By:  /s/ JOHN N. URBAN
     ------------------------------------

Its: John N. Urban
     Assistant Director
     Commercial Real Estate/Equities

<PAGE>   23
                                   EXHIBIT A
                                    PREMISES

LEGAL DESCRIPTION OF REAL PROPERTY:

All that certain real property in the City of Sunnyvale, County of Santa Clara,
State of California, described as follows:

All of Parcel 4, shown upon that certain Map entitled, "Parcel Map being a
resubdivision of Parcel 5 as shown on Map recorded in Book 413 of Maps at Page
53, Santa Clara County Records", which Map was filed for record in the Office of
the Recorder of the County of Santa Clara, State of California, on July 18, 1978
in Book 423 of Maps at Page 13.

                                       13
<PAGE>   24
                                   EXHIBIT B

                             WORK LETTER AGREEMENT

Lessee and Lessor are executing simultaneously with this Work Letter Agreement,
a lease (the "Lease") of even date herewith covering certain Premises described
on Page 1 of the Lease. This Work Letter Agreement is incorporated into said
Lease as Exhibit "B" thereto. In consideration of the mutual covenants contained
in the Lease, Lessee and Lessor hereby agree that the Premises shall be improved
as set forth herein.

1. BASE BUILDING: Lessor and Lessee understand and acknowledge that this Work
Letter Agreement relates only to the construction of "non-base building"
improvements ("Tenant Improvements") for the Premises.

2. PRELIMINARY PLANS AND SPECIFICATIONS:

      a. PRELIMINARY PLANS: Lessee and Lessor have prepared, using Lessee's
architect, a preliminary plan and an outline of specifications ("Preliminary
Plans") for the construction of the Tenant Improvements for the Premises.

      b. PRELIMINARY CONSTRUCTION DRAWINGS: Lessee shall deliver to Lessor, not
later than January 30, 1996, a preliminary design for the Premises ("Preliminary
Construction Drawings") based upon the Preliminary Plans.

      c. DESIGN INFORMATION: Lessee shall deliver to Lessor, not later than
February 15, 1996, information (the "Design Information") sufficient to permit
Lessor to approve the "Plans" described in Paragraph 3 below. Such information
to be supplied by Lessee shall include its mark-up of the Preliminary
construction Drawings, as well as all necessary design criteria for the
construction of the Tenant Improvements, including, without limitation, the
following information:

            a. The locations of doors (including the truck door), partitioning,
ceiling layouts, lighting fixtures, electrical outlets and switches, and
telephone outlets;

            b. The location and extent of special floor loading;

            c. The location and description of plumbing requirements;

            d. The amount of additional electrical loads and location of areas
requiring such additional electrical loads;

            e. Any structural or architectural installations, including
locations for roof-mounted package air-conditioning units;

            f. The location and dimensions of telephone equipment rooms; and

            g. Other special requirements.

3. FINAL PLANS: Lessee shall prepare or cause to be prepared final plans and
specifications substantially in conformity with the Preliminary Plans and which
incorporate the Design Information to be delivered to Lessor pursuant to
Paragraph 2(b) above. "Plans" shall hereinafter mean final plans as may be
changed from time to time in accordance with Paragraph 6 below. All Plans shall
be delivered to Lessor as soon as reasonably possible from the date hereof,
subject, however to periods of delay encountered by Lessee in the preparation of
Plans resulting from requests by Lessor for changes in the Plans subsequent to
the date hereof. Within ten (10) days after delivery of the Plans, Lessor shall
set forth in writing with particularity and precision any correction or changes
necessary to bring the Plans into substantial conformity with the Preliminary
Plans and the Design Information, except that Lessor may not object to any
logical development or refinement of the Preliminary Plans and the Design
Information. Lessor and Lessee hereby agree to act with diligence to cause the
Plans to be approved

                                       14
<PAGE>   25
and signed by the parties, in duplicate, by no later than February 28, 1996.
Following such approval and execution of the Plans changes may be made only in
accordance with Paragraph 8 below. In the event that Lessee fails to approve the
Plans pursuant to the provisions of this Paragraph 3 and as a result of such
failure this Lease is terminated, unless such failure is due to Lessor's
unreasonable interpretation of the Preliminary Plans and Design Information.

4. IMPROVEMENT ALLOWANCE: Lessor hereby agrees to fund an improvement allowance
of $9.00/square foot ($489,870.00) as Tenant Improvement Allowance. In addition,
Lessor will provide, at its sole cost: i) New roof and roof screen on building,
ii) Exterior ADA compliance items, iii) Newly sealed and striped parking lot
pavement, iv) A voluntary seismic structural upgrade to building (to the 1991
Uniform Building Code). [Tenant hereby acknowledges that Landlord has
satisfactorily completed 4(iii) and 4(iv) above], (v) New factory curb mounted,
roof-top, package HVAC units [Tenant shall be responsible for all ducting and
distribution of conditioned air] to serve Tenant's approved floor plans for a
generic research and development facility [extra costs for HVAC unit/s or
capacity to serve Tenant's clean room or other non-generic R&D space will be
funded by Tenant]. Tenant shall be responsible for all interior ADA compliance
changes. Tenant shall pay to Tarlton Properties, Inc., a fixed Construction
Monitoring Fee of $25,000 for Tenant's designing construction work, to insure
that Landlord's interests are adequately represented during the design,
construction and occupancy.

5. CONSTRUCTION: Upon approval by the parties of the Construction Drawings,
Lessee shall use its commercially reasonable best efforts to substantially
complete the Improvements on or before the Anticipated Commencement Date set
forth in Paragraph 2 of the Lease. Lessor shall not be liable for any direct or
indirect damages as a result of delays in construction of the Improvements due
to events "force majeure events" which generally affect the progress of
construction beyond Lessee's reasonable control, including, but not limited to,
fire, earthquake, inclement weather or other acts of God, strikes, boycotts;
availability of materials and labor; changes in governmental regulations or
requirements; changes in the Plans or Improvement Budget pursuant to Paragraph 6
below; or Lessee Delays defined in Paragraph 4(d) of the Lease.

6. CHANGES IN PLANS: From and after the date on which The Plans have been
approved by Lessor and Lessee pursuant to Paragraph 3 above, Lessee shall have
the right to request changes in the Plans, provided, however, that; (a) such
requests shall not result in any structural or material change in the Tenant
Improvements as determined by Lessor; (b) such requests conform to applicable
governmental agencies and, if necessary, are approved by the applicable
governmental agencies; (c) all additional charges of implementing such changes
including, without limitation, architectural fees, increases in construction
costs and other related charges shall be included in Lessee's Costs and payable
by Lessee in accordance with the provisions of Paragraph 5 above; (d) such
requests shall constitute an agreement on the part of Lessee to any delay in
completion of the Tenant Improvements caused by reviewing, processing and
implementing the changes; and (e) such requests shall constitute "Lessee
Delays". Each request for changes in accordance herewith shall be in writing and
if approved by Lessor, shall be approved in writing.

7. COMPLETION OF TENANT IMPROVEMENTS: The Premises shall be deemed to be "Ready
for Occupancy" when the work of construction of the Tenant Improvements has been
substantially completed in accordance with the Plans (subject to the normal
so-called "punch list items") as evidenced by the delivery to Lessor and Lessee
of a certificate from Lessor's Construction Manager with a copy of a temporary
certificate (if legally required as a condition of occupancy) permitting
occupancy of the Premises issued by the City of Sunnyvale. Lessee shall
diligently complete as soon as reasonably possible any items of work and
adjustment not completed when the Premises are Ready for Occupancy. Lessee
hereby agrees to indemnify, defend and hold Lessor harmless from and against any
liens filed in connection with the construction of the Tenant Improvements.

                                       15
<PAGE>   26
8.   QUALITY OF CONSTRUCTION: Lessor and Lessee hereby agree that all Tenant
     Improvements (except HVAC units mounted on roof plus roof screen) shall be
     constructed by Rudolph & Sletten, Inc. Lessee hereby agrees that the
     general contractor's construction manager shall have previous experience in
     similar projects which is reasonably satisfactory to Lessor. Lessee
     warrants and represents to Lessor that all work shall be done in a good and
     workmanlike manner and in compliance with all applicable laws and lawful
     ordinances, by-laws, regulations and orders of governmental authority and
     the of the insurers of the Building. Lessor makes no representations,
     warranties or guarantees, expressed or implied, including warranties of
     merchantability or use of the Premises, except as expressly set forth
     herein and in the Lease. Upon written request by Lessor in each instance,
     Lessee shall enforce for the benefit of Lessor all warranties, if any,
     received by Lessee from Rudolph & Sletten, Inc. or others in connection
     with the construction of the Tenant Improvements to the extent that said
     warranties cover any defects in the Improvements which Lessee is required
     to repair hereunder.

9.   CONSTRUCTION REPRESENTATIVE: In connection with the original construction
     of the Tenant Improvements, each party shall be bound by the acts of its
     respective Construction Representative appointed by each party upon the
     execution of this Lease. Lessor's Construction Representative is L. C.
     (Tig) Tarlton, Jr., or John C. Tarlton and Lessee's Construction
     Representative is James P. Driessen. A party may designate a substitute
     Construction Representative by giving written notice to the other party.

10.  COURSE OF CONSTRUCTION INSURANCE: Lessee and Lessee's General Contractor
     shall maintain full course of Construction Insurance, with limits of
     $5,000,000, with Lessor and Lessor's Agent named as additional insured.

                                       16
<PAGE>   27
                                  EXHIBIT B-1

               WORK LETTER ADDENDUM: TENANT FINISH WORK: "AS-IS"

1.   As the Premises have heretofore been occupied by a prior tenant, then
     except as set forth in this Exhibit and the Lease, Tenant accepts the
     Premises in its "as-is" condition on the date that this Lease is entered
     into, except for any hidden or latent defects. Landlord warrants that, on
     or before the Commencement Date of this Lease, all building systems,
     including but not limited to, HVAC, plumbing, roof, electrical,
     landscaping and parking area (excluding Tenant Work) are in good working
     order and repair.

2.   On or before the date hereof, Tenant shall provide to Landlord for its
     approval final working drawings, prepared on AutoCAD Release 12, of all
     improvements that Tenant proposes to install in the Premises; such working
     drawings shall include the partition layout, ceiling plan, electrical
     outlets and switches, telephone outlets, drawings for any modifications to
     the mechanical and plumbing systems of the Building, and detailed plans
     and specifications for the construction of the improvements called for
     under this Exhibit in accordance with all applicable governmental laws,
     codes, rules, and regulations. Further, as Tenant's proposed construction
     work will affect the Building's HVAC, electrical, mechanical, or plumbing
     systems, then the working drawings pertaining thereto shall be prepared by
     a licensed engineer reasonably acceptable to Landlord, whom Tenant shall
     at its cost engage for such purpose, except for the specification of
     generic HVAC package units on the roof, which work will be done by Western
     Allied Air Conditioning Co., Landlord's approval of such working drawings
     shall not be unreasonably withheld or delayed, provided that (a) they
     comply with all applicable governmental laws, codes, rules, and
     regulations, (b) such working drawings are sufficiently detailed to allow
     construction of the improvements in a good and workmanlike manner, and (c)
     the improvements depicted thereon conform to the rules and regulations
     promulgated from time to time by Landlord for the construction of tenant
     improvements (a copy of which has been delivered to Tenant). As used
     herein, "Working Drawings" shall mean the final working drawings approved
     by Landlord, as amended from time to time by any approved changes thereto,
     and "Work" shall mean all improvements to be constructed in accordance
     with and as indicated on the Working Drawings. Approval by Landlord of the
     Working Drawings shall not be a representation or warranty of Landlord
     that such drawings are adequate for any use, purpose, or condition, or
     that such drawings comply with any applicable law or code, but shall
     merely be the consent of Landlord to the performance of the Work. All
     material changes (defined below) in the Work must receive the prior
     written approval of Landlord, and in the event of any such approved change
     Tenant shall, upon completion of the Work, furnish Landlord with (1) an
     accurate, reproducible "as-built" plan (e.g., sepia) of the improvements
     as constructed, which plan shall be incorporated into this Lease by
     reference for all purposes and (2) an accurate "as-built" plan of the
     improvements as constructed on a computer disk (AutoCAD Release 12). As
     used herein, a "material change" shall mean any change relating to HVAC,
     electrical, plumbing or other mechanical systems of the Building; floor
     and roof loading or the structure of the building; window treatment,
     signs, graphics and other quality, appearance, or other aesthetic
     consideration visible outside the Premises.

3.   On or before the date hereof, Tenant shall provide to Landlord for its
     approval all construction documents relating to the Work. If Landlord
     fails to respond within ten (10) calendar days of Landlord's receipt of
     such construction documents, Landlord shall be deemed to have granted its
     approval of such construction documents as submitted. Landlord may
     reasonably require modifications or clarifications to the construction
     documents, provided such changes are not related to Tenant's space
     planning of the Premises or the functional requirements of Tenant's
     intended use of the Premises.

4.   The Work shall be performed only by contractors and subcontractors
     approved in writing by Landlord, which approval shall not be unreasonably
     withheld. Prior to the bidding of the Work, Landlord may exclude, using
     Landlord's reasonable

                                       17

<PAGE>   28
   discretion, specific subcontractors, and such exclusions shall be included in
   Tenant's bid documents. For the purposes of this Exhibit, the following
   contractors are approved by Landlord for the performances of the Work:
   Rudolph and Sletten, Inc.; Western Allied Air Conditioning; TL Electric;
   Ramcon Plumbing. All contractors and subcontractors shall be required to
   procure and maintain insurance against such risks, in such amounts, and with
   such companies as Landlord may reasonably require. Certificates of such
   insurance must be received by Landlord before the Work is commenced. The Work
   shall be performed in a good and workmanlike manner that is free of defects
   and is in strict conformance with the Working Drawings, and shall be
   performed in such a manner and at such times as to maintain harmonious rules
   and regulations of all governmental authorities and the labor relations and
   not to interfere with the operation of the Building. Tenant may reuse any
   existing improvements and/or materials located within the Premises at
   Tenant's discretion. Landlord shall have access at all times to the Building
   to inspect the Work. Any variance from the construction documents or the
   rules or regulations of any governmental authority shall be corrected
   immediately.

5. Tenant shall maintain the exterior of the Building free from clutter and
   debris at all times during the performance of the Work. Tenant shall
   immediately clear any clutter or debris from the area surrounding the
   Building. If such area is not fully clean of debris and clutter within 24
   hours of written notification, Landlord may clean such area and invoice
   Tenant therefor, which invoice shall be payable by Tenant within ten days.

6. Upon substantial completion of the Work, Tenant and Landlord's agent shall
   conduct a walk-through inspection of the Building and create a mutually
   agreed upon "punchlist" setting forth any remaining construction items to be
   completed. If any discrepancies or disputes exist or arise between Tenant and
   Landlord's agent regarding the punchlist items, DES Architects and Engineers
   of Redwood City, CA is hereby appointed by Landlord and Tenant as arbitrator
   of any such dispute. All fees and expenses of DES shall be divided evenly
   between Landlord and Tenant and DES's decision shall be final.

7. Tenant shall bear the entire cost of performing the Work (including, without
   limitation, design of the Work and preparation of the Working Drawings, costs
   of preparation of all construction documentation, Costs of construction labor
   and materials, electrical and gas usage during Construction, additional
   janitorial services, general tenant signage, related taxes and insurance
   costs, all of which costs are herein collectively called the "Total
   Construction Costs"). Tenant shall cause the Work in the Premises to be
   promptly completed by the approved contractors.

8. Landlord shall have no liability or responsibility (and Tenant releases
   Landlord from any and all liability or responsibility) for deficiencies in
   the Work and/or performance of any equipment, including, without limitation,
   any problems arising from existing conditions in the Building and any
   conditions arising from the existing condition of the Premises (other than
   any hidden or latent defects in the Premises existing as of the date hereof)
   or from the use of new and recycled materials or equipment in Premises.

9. To the extent not inconsistent with this Exhibit B-1, Exhibit B of this Lease
   shall govern the performance of the Work and Landlord's and Tenant's
   respective rights and obligations regarding the improvements installed
   pursuant thereto.

                                       18
<PAGE>   29

                                   EXHIBIT C
                              RULES & REGULATIONS
                                  PAGE 1 OF 1

                                  LEASE DATED
                                FEBRUARY 1, 1996

                                MEDTRONIC, INC.
                                   ("LESSEE")

                                      AND

                    PRINCIPAL MUTUAL LIFE INSURANCE COMPANY,
                              AND IOWA CORPORATION
                                   ("LESSOR")

      1. No advertisement, picture or sign of any sort shall be displayed on or
outside the Premises without the prior written consent of Lessor. Lessor shall
have the right to remove any such unapproved item without notice and at Lessee's
expense.

      2. Lessee shall not regularly park motor vehicles in designated parking
areas after the conclusion of normal daily business activity.

      3. Lessee shall not use any method of heating or air conditioning other
than that supplied by Lessor without the consent of Lessor.

      4. All window covering installed by Lessee and visible from the outside of
the building require the prior written approval of Lessor.

      5. Lessee shall not use, keep or permit to be used or kept any foul or
noxious gas or substance or any flammable or combustible materials on or around
the Premises.

      6. Lessee shall not alter any lock or install new locks or bolts on any
door at the Premises without the prior consent of Lessor.

      7. Lessee agrees not to make any duplicate keys without the prior consent
of Lessor.

      8. Lessee shall park motor vehicles in those general parking areas as
designated by lessor except for loading and unloading. During those periods of
loading and unloading, Lessee shall not unreasonably interfere with traffic
flow within the Project and loading and unloading areas of other Lessees.

      9. Lessee shall not disturb, solicit or canvas any occupant of the
Building or Project and shall cooperator to prevent same.

      10. No person shall go on the roof without Lessor's permission.

      11. Business machines and mechanical equipment belonging to Lessee which
cause noise or vibration that may be transmitted to the structure of the
Building, to such a degree as to be objectionable to Lessor or other Lessee,
shall be placed and maintained by Lessee, at Lessee's expense, on vibration
eliminators or other devices sufficient to eliminate noise or vibration.

      12. All goods, including material used to store goods, delivered to the
Premises of Lessee shall be immediately moved into the Premises and shall not be
left in parking or receiving areas overnight.

      13. Tractor trailers which must be unhooked or parked with dolly wheels
beyond the concrete loading areas must use steel plates or wood blocks under the
dolly wheels to prevent damage to the asphalt paving surfaces. No parking or
storing of such

                                       19
<PAGE>   30

trailers will be permitted in the auto parking areas of the Project or on
streets adjacent thereto.

      14. Forklifts which operate on asphalt paving areas shall not have solid
rubber tires and shall only use tires that do not damage the asphalt.

      15. Lessee is responsible for the storage and removal of all trash and
surface. All such trash and refuse shall be contained in suitable receptacles
stored behind screened enclosures at locations approved by Lessor.

      16. Lessee shall not store or permit the storage or placement of goods or
merchandise in or around the common areas surrounding the Premises. No displays
or sales or merchandise shall be allowed in the parking lots or other common
areas.

                                       20
<PAGE>   31

                                   ADDENDUM 1

                              ADJUSTMENTS TO RENT

                                  PAGE 1 OF 1

                                  LEASE DATED
                                FEBRUARY 1, 1996

                                MEDTRONIC, INC.
                                   ("LESSEE")

                                      AND

                    PRINCIPAL MUTUAL LIFE INSURANCE COMPANY,
                              AN IOWA CORPORATION
                                   ("LESSOR")

     1.   Lessor and Lessee agree that the Base Rent referenced on Page 1 and
on Page 2, Paragraph 3 of the lease shall be as follows:

       MONTH               RENT/S.F./MONTH, NET               RENT/MONTH

                                       21
<PAGE>   32

                                   EXHIBIT D
                          COMMENCEMENT DATE MEMORANDUM

LESSOR:             PRINCIPAL MUTUAL LIFE INSURANCE COMPANY,
                    AN IOWA CORPORATION

LESSEE:             MEDTRONIC, INC.,
                    A MINNESOTA CORPORATION

LEASE DATE:         February 1, 1996

PREMISES:           1312 Crossman Ave., Sunnyvale, CA

Pursuant to Paragraph 2, of the above referenced Lease, the Commencement Date
is hereby established as May 1, 1996.

                                                       LESSOR

Dated: 7/10, 1996                       PRINCIPAL MUTUAL LIFE INSURANCE COMPANY,
                                        AN IOWA CORPORATION

                                        By: /s/ Timothy E. Minton
                                            ------------------------------------

                                        Its: Director Commercial Real Estate
                                             Reporting and Computer Services
                                             -----------------------------------

                                        By: /s/ Kurt D. Schaeffer
                                            ------------------------------------

                                        Its: Assistant Director
                                             Commercial Real Estate
                                             -----------------------------------

                                                       LESSEE

                                        MEDTRONIC, INC., A MINNESOTA CORPORATION

Dated 6-26, 1996                        By: /s/ [signature illegible]
                                            ------------------------------------

                                        Its: V.P. of Corporate Services
                                             -----------------------------------

                                        By: /s/ [signature illegible]
                                            ------------------------------------

                                        Its: Real Estate Specialist
                                             -----------------------------------

                                       22
<PAGE>   33
                                   EXHIBIT E

                   SAMPLE FORM OF TENANT ESTOPPEL CERTIFICATE

The undersigned, __________________ ("Lessor"), with a mailing address c/o
_______________________________________, and ______________________________
{"Tenant"), hereby certify to __________________________________________, a
_________________________________as follows:

1.   Attached hereto is a true, correct and complete copy of that certain lease
dated ________, 199_ between Lessor and Lessee (the "Lease"), which demises
premises located at ________________________________________________. The Lease
is now in full force and effect and has not been amended, modified or
supplemented, except as set forth in paragraph 4 below.

2.   The term of the Lease commenced on _______________, 199__.

3.   The term of the Lease shall expire on __________________, 199__.

4.   The Lease has: (Initial one)

     ( ) not been amended, modified, supplemented, extended, renewed or
assigned.

     ( ) been amended, modified, supplemented, extended, renewed or assigned by
the following described agreements, copies of which are attached hereto: ____
_____________________________________________________________________________
_____________________________________________________________________________
_____________________________________________________________________________

5.   Lessee has accepted and is now in possession of said premises.

6.   Lessee and Lessor acknowledge that the Lease will be assigned to
________________________________ and that no modification, adjustment, revision
of cancellation of the Lease or amendments thereto shall be effective unless
written consent of ______________________ is obtained, and that until further
notice, payments under the Lease may continue as heretofore.

7.   The amount of fixed monthly rent is $_______________________.

8.   The amount of security deposits (if any) is $ ________________. No
other security deposits have been made.

9.   Lessee is paying the full lease rental, which have been paid in full
as of the date hereof. No rent under the Lease has been paid for more than
thirty (30) days in advance of its due date.

10.  All work required to be performed by Lessor under the lease has been
completed.

11.  There are no defaults on the part of the Lessor or Lessee under the
Lease.

12.  Lessee has no defense as to its obligations under the Lease and claims
no set-off of counterclaim against Lessor.

13.  Lessee has no right to any concession (rental or otherwise) or similar
compensation in connection with renting the space it occupies, except as
provided in the Lease.

All provisions of the Lease and the amendments thereto (if any) referred to
above are hereby ratified.

The foregoing certification is made with the knowledge that
____________________ is about to fund a loan to Lessor, and that
____________________ is relying upon the representations herein made in funding
such loan.

                                       23

<PAGE>   34

                                                   LESSOR

Dated: ______________, 1996           PRINCIPAL MUTUAL LIFE INSURANCE COMPANY,
                                      AN IOWA CORPORATION

                                      By:
                                         -------------------------------------

                                      Its:
                                         -------------------------------------

                                      By:
                                         -------------------------------------

                                      Its:
                                         -------------------------------------

                                                   LESSEE

Dated: ______________, 1996           MEDTRONIC, INC., A MINNESOTA CORPORATION

                                      By:
                                         -------------------------------------

                                      Its:
                                         -------------------------------------

                                      By:
                                         -------------------------------------

                                      Its:
                                         -------------------------------------

                                       24<PAGE>   1
                                                                   EXHIBIT 10.06

                                AMENDMENT TO THE
                          GENELABS TECHNOLOGIES, INC.
                          ANNUAL & LONG TERM INCENTIVE
                            BASED COMPENSATION PLAN

                            Effective July 29, 1994
                            Amended October 7, 1994
                        Amended & Renewed July 29, 1997
           Amended & Renewed June 1, 2000 for the Term July 29, 2000
                 through June 28, 2003 Amended February 2, 2001

This amendment is dated as of February 2, 2001 (the "Amendment"), and amends
that certain Genelabs Technologies, Inc. Annual and Long Term Incentive Based
Compensation Plan originally effective as of July 29, 1994, as amended and
renewed (the "Plan").

On June 1, 2000, the Board of Directors of Genelabs Technologies approved the
extension of the Plan for an additional three-year term, through July 28, 2003,
pursuant to Sections 12 and 15 of the Plan.

On February 2, 2001, the Board of Directors of Genelabs Technologies approved
the amendment of the Plan as attached hereto as Appendix A, superseding all
prior versions of the Plan.

<PAGE>   2
                                                                      APPENDIX A

                           GENELABS TECHNOLOGIES, INC.
                          ANNUAL & LONG TERM INCENTIVE
                             BASED COMPENSATION PLAN

                             Effective July 29, 1994
                             Amended October 7, 1994
              Amended & Renewed July 29, 1997 Renewed June 1, 2000
                   for term July 29, 2000 through July 28, 2003
                            Amended February 2, 2001

1.       PURPOSE

         The purpose of this Genelabs Technologies, Inc. Annual and Long-Term
         Incentive Based Compensation Program (the "Plan") is to enable Genelabs
         Technologies, Inc. and its wholly owned subsidiaries (the "Company") to
         (i) attract, retain and motivate employees who contribute to the
         success of the Company, (ii) reward performance in the achievement of
         corporate objectives and, (iii) provide an incentive to senior
         executives and designated key employees to increase the profitability
         and advance the interests of the Company through participation in a
         bonus plan in accordance with the provisions of this Plan.

2.       DEFINITIONS

         For purposes of this Plan, the following terms shall be defined as
         follows:

         a.       "Award" means an Incentive Award that may be granted to a
                  Participant upon completion of certain performance conditions
                  set forth in this Plan.

         b.       "Award Cycle" means a period during which Company and
                  individual performance is measured as determined by the Board
                  of Directors of the Company (the "Board") from time to time.
                  Participants may participate in one or more Award Cycles,
                  which may run concurrently or successively.

         c.       "Award Level" means one of three categories into which
                  Participants are classified as set forth in Section 5 of this
                  Plan.

         d.       "Company Objectives" means the criteria of measurement of
                  individual, division, department or company wide performance
                  goals. In the case of individual, division or departmental
                  performance goals, these are

<PAGE>   3
                  established by the Participant's manager and approved by
                  management of the Company; in the case of company-wide
                  performance goals, these are approved by the Board, pursuant
                  to Section 4 of this Plan for each Award Cycle, including but
                  not limited to budgeting and cash flow objectives. The
                  Company's Incentive Based Compensation ("IBC") Plan is the key
                  driver of this Plan.

         e.       "Fiscal Year" means the fiscal year of the Company, which is
                  January 1 to December 31.

         f.       "Incentive Award" means an Award that may be granted to a
                  Participant upon completion of Company Objectives pursuant to
                  the terms of Sections 4, 5, and 6 of this Plan.

         g.       "Incentive Percentage" means the percentage, if any, of the
                  total base salaries of the Participants during an Award Cycle,
                  as determined by the Board, in the case of company wide
                  performance or performance of senior executives, and as
                  determined by management, in the case of individual, division
                  or department performance, for each Award Cycle if certain
                  Company Objectives are satisfied.

         h.       "Participant" means any regular employee of the Company who
                  has been with the Company a minimum of 90 days.

3.       MAXIMUM AMOUNT OF AWARDS

         There is no maximum limit on aggregate awards paid with respect to any
         Award Level.

4.       DETERMINATION OF COMPANY AND INDIVIDUAL PERFORMANCE OBJECTIVES

         a.       Company Objectives. With respect to each Award Cycle, the
                  Board shall establish the company wide Company Objectives,
                  based upon the recommendations of Executive Management. The
                  measurement of the Company Objectives for each Award Cycle
                  shall be based on (i) the attainment of certain division,
                  department or company wide strategic objectives, and (ii) the
                  attainment of certain individual, division, department or
                  company wide financial objectives, including annual budgeted
                  spending and/or annual revenue/income and cash flow targets.

<PAGE>   4
         b.       Written Description. The Company Objectives shall be set forth
                  in writing and communicated to each Participant during each
                  Award Cycle.

5.       CALCULATION OF AMOUNT OF INCENTIVE AWARD

         a.       Award Levels. Unless otherwise determined by the Board, each
                  Participant will be eligible to receive an Incentive Award in
                  an amount calculated according to the Award Level for such
                  Participant set forth below. A Participant may participate in
                  more than one Award Level if such Participant is eligible for
                  such Award Level.

<TABLE>
<CAPTION>
                       Award
                       Level     Description           Participant
                       -----     -----------           -----------
<S>                    <C>       <C>                   <C>
                         1       Annual Award          All Participants

                         2       Annual Award          Directors and Above

                         3       Long-Term             Vice Presidents and Above
                                 Incentive             or at the discretion of
                                                       the HR Committee
</TABLE>

                  Unless otherwise determined by the Board the achievement of
                  Company Objectives will be apportioned for each Award Level as
                  follows:

                  (1)      Award Level 1 - Annual Award. A Participant shall be
                           eligible to receive up to ten (10%) percent of his or
                           her salary multiplied by the applicable percentage
                           for completion of Company objectives. Notwithstanding
                           the foregoing, the aggregate of all awards may not
                           exceed the maximum amount of awards set forth in
                           Section 3 of this Plan and if such maximum would be
                           exceeded but for this sentence, all Incentive Awards
                           shall be decreased proportionately.

                  (2)      Award Level 2 -Annual Award. A designated Participant
                           shall be eligible to receive up to forty (40%)
                           percent of his or her salary as determined pursuant
                           to Section 5(b).

                  (3)      Award Level 3 - Long-Term Incentive. A designated
                           Participant shall be eligible to receive up to
                           thirty-five (35%) percent of his or her salary on a
                           deferral basis (Long-Term Incentive) over a period of
                           three (3) years paid 33% each year.

<PAGE>   5
                           This discretionary level may include any member of
                           the Company approved by the CEO and presented at the
                           HR Committee.

         b.       Percentage of Salary. With respect to each Award Cycle, the
                  Board shall establish for all Participants based upon the
                  recommendations of the Chief Executive Officer, the Incentive
                  Percentage to be paid to each Organizational Level for
                  achievement of each of the Company Objectives.

         c.       Incentive Awards made to a designated Participant. Incentive
                  Awards made to Participants in Award Level 3 (Long-Term
                  Incentive) shall be paid in accordance with the following
                  vesting schedule, unless otherwise determined by the Board of
                  Directors:

<TABLE>
<CAPTION>
                  YEARS OF EMPLOYMENT
                  BASED ON AWARD CYCL                                             PERCENTAGEE
                  (JAN 1 - DEC 31)                                                  OF AWARD
                  --------------------                                          ----------------
<S>                                                                             <C>
                  Less than one full year of                                        up to 10%
                  employment  from the first day of                                 pro-rated
                  the Award Cycle                                                (discretionary)

                  One full year of service                                            (1/3)
                  from the first day of the                                      66.6% of Award
                  previous Award Cycle

                  Two full years of service                                           (2/3)
                                                                                 66.6% of Award

                  Three or more full years                                            (3/3)
                  of service                                                      100% of Award
</TABLE>

6.       GRANT OF THE INCENTIVE AWARDS

         a.       As soon as practicable after the end of an Award Cycle but no
                  later than April 1 following the end of such Award Cycle, the
                  Board, shall determine whether the Company has achieved any of
                  the Company Objectives. Based upon (A) the degree of
                  achievement of Company Objectives and (B) the Incentive
                  Percentage determined by the Board for the Award Cycle, the
                  Board shall grant an Incentive Award to Participants in
                  accordance with Section 5 of this Plan.

<PAGE>   6
         b.       Participants who do not complete 12 months of employment in
                  the calendar year shall be eligible for a pro-rated share of
                  an Award with respect to such Award Cycle.

7.       TERMINATION OF SERVICE

         If, during an Award Cycle, a Participant's employment with the Company
         terminates by reason of death, permanent disability (as defined in the
         Company's group long-term disability plan) or retirement, the Board in
         its sole discretion may cause to be paid to the Participant or his or
         her designated beneficiary an Award, or a pro-rated share of an Award,
         if any, based upon the service performed during the Award Cycle and
         upon the degree of achievement of Company Objectives for such Award
         Cycle. Any such payment of an Award shall be made to the Participant or
         his or her beneficiary in the Fiscal Year following permanent
         disability, death or retirement. A Participant who terminates
         employment with the Company prior to the end of an Award Cycle for any
         reason other than death, permanent disability or retirement shall not
         be entitled to receive any Award.

8.       TIME AND FORM OF PAYMENT

         An Award shall be paid to the Participant or his or her designated
         beneficiary as soon as practicable after the end of the Award Cycle, or
         in the case of a Level 3 Award, at the time that such Award becomes
         vested pursuant to Section 5(c) of this Plan, in cash. Common Stock may
         at times be considered but it is not a requirement. The form of payment
         of Awards in Award Level 3 is intended to be primarily in the form of
         cash (supplemented by stock). Notwithstanding the foregoing, Awards
         will be paid to Participants who are Directors or Officers (as defined
         in Section 16 of the Exchange Act of 1934, as amended) of the Company
         only in the form of cash.

9.       DESIGNATION OF BENEFICIARY

         The effective designation of a beneficiary under the Company's Section
         401(k) Plan (including any required spousal consent) shall for all
         purposes also be deemed a designation of beneficiary under this Plan.
         If no such beneficiary designation is in effect at the time of a
         Participant's death, or if no designated beneficiary survives the
         Participant, or if such designation conflicts with the law, the payment
         of the amount, if any, payable under the Plan upon his or her death
         shall be made to the Participant's estate. If the Company is in doubt
         as to the right of any person to receive any amount, the Company may

<PAGE>   7
         retain such amount, without liability for any interest thereon, until
         the rights thereto are determined, or the Company may pay such amount
         into any court of appropriate jurisdiction, and such payment shall be a
         complete discharge of the liability of the Company.

10.      NO CONTINUED EMPLOYMENT

         Nothing in this Plan or any award granted hereunder shall confer upon
         any participant any right to continue in the employ of the Company or
         interfere in any way with the right of the Company to terminate his or
         her employment at any time. No award payable under the Plan shall be
         deemed salary or compensation for the purpose of computing benefits
         under any other employee benefit plan or other arrangement of the
         Company for the benefit of its employees unless the Company shall
         determine otherwise.

11.      LEAVE OF ABSENCE

         Absence on leave approved by the Company shall not be considered
         interruption or termination of employment for any purposes of the Plan
         unless the Board determines otherwise; provided, however, that no Award
         may be granted to an employee while he or she is absent on leave.

12.      ADMINISTRATION

         The Plan shall be administered by the Board or by the Human Resources
         Committee or such other committee appointed by the Board. The Board
         shall have full power, discretion and authority to interpret, review,
         renew, and administer the Plan. The Board's interpretation and
         application of the Plan shall be binding and conclusive for all persons
         for all purposes. The Board may conclusively rely upon any opinion,
         computations or other advice received from any such counsel,
         independent auditors or consultants. The Board's actions may include,
         but not be limited to, the determination of:

         a.       the employees of the Company to be designated as Participants
                  upon recommendation of the Chief Executive Officer of the
                  Company,

         b.       the Incentive Percentage for each Award Cycle,

         c.       the achievement of Company Objectives,

         d.       the Award Levels or the amount of any Award payable with
                  respect to any Award Level, and

         e.       the specific terms, conditions and restrictions of any

<PAGE>   8
                  Award consistent with the terms of this Plan.

13.      WITHHOLDING

         The amount payable to a participant or his or her beneficiary shall be
         reduced by any amount that the Company is required to withhold with
         respect to such payments under the then applicable provisions of
         federal, foreign, state or local income tax laws unless the Participant
         satisfies such withholding requirements in some other manner approved
         by the Board

14.      UNFUNDED PLAN; GOVERNING LAW

         Nothing contained in the Plan, and no action taken pursuant to its
         provisions, shall create or be construed to create a trust of any kind,
         or a fiduciary relationship between the Company or the Board, or both,
         on the one hand, and any Participant or other person on the other. To
         the extent that any person acquires a right to receive payments from
         the Company under this Plan, such right shall be no greater than the
         right of an unsecured general creditor of the Company. All payments to
         be made hereunder shall be paid from the general funds of the Company
         and no special or separate fund shall be established and no segregation
         of assets shall be made to assure payments of such amounts. The Plan is
         an unfunded incentive compensation plan and all rights hereunder shall
         be governed by and construed in accordance with the laws of California.

15.      AMENDMENT OR TERMINATION OF THE PLAN

         The Plan shall be effective on July 29, 1994. Awards may be granted
         pursuant to this Plan from time to time within a period of three (3)
         years from the date on which this Plan is approved by the Board. The
         Board may terminate this Plan at any time, or amend it from time to
         time.

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