Document:

Form of Employment Agreement

 Exhibit 10.64 
  
 FORM OF EMPLOYMENT AGREEMENT 
  
 EMPLOYMENT AGREEMENT 
  
 This Employment Agreement is made and entered into by and between E*TRADE Financial Corporation (the “Company”) and
            (“Executive”) as of             , 2004 (the “Effective Date”). 
  
 1. Position and Duties: Executive shall be employed by the Company as
its             , reporting [to the Company’s President][to the Company’s Chief Executive Officer][only to
            ’s Board of Directors (the “Board”)]. As its [            ], Executive agrees to
devote his/her full business time, energy and skill to his/her duties at the Company. These duties shall include all those duties customarily performed by the [            .] During
the term of Executive’s employment, Executive shall be permitted to serve on boards of directors of for-profit or not-for-profit entities provided that the Board of Directors of the Company (the “Board’) has approved such service in
writing, and only so long as such service does not adversely affect the performance of Executive’s duties to the Company under this Agreement. If the Board requests Executive to resign from such position at any time, Executive shall resign
immediately. 
  
 [(Language for CEO only): In addition,
Executive has been elected to the Board. As a member of the Company’s Board, Executive shall continue to be subject to the provisions of the Company’s bylaws and all applicable general corporation laws relative to his position on the
Board. In addition to the Company’s bylaws, as a member of the Board, Executive shall also be subject to the statement of powers, both specific and general, set forth in the Company’s Articles of Incorporation.] 
  
 2. Term of Employment: This Agreement shall remain in effect for a
period of three years from the Effective Date, and will automatically renew for additional one year periods unless either party provides ninety days’ prior notice of termination. In the event the Company elects to terminate the agreement, such
termination shall be considered to be an Involuntary Termination, and Executive shall be provided benefits as provided in this Agreement. Upon the termination of Executive’s employment for any reason, neither Executive nor the Company shall
have any further obligation or liability under this Agreement to the other, except as set forth below. 
  
 3. Compensation: Executive shall be compensated by the Company for his services as follows: 
  
 (a) Base Salary: As
[            ], Executive shall be paid a monthly Base Salary of $             per month
($             on an annualized basis), subject to applicable withholding, in accordance with the Company’s normal payroll procedures. Executive’s salary shall be reviewed
on at least an annual basis and may be adjusted as appropriate. In the event of such an adjustment, that amount shall become Executive’s Base Salary. 

 (b) Benefits: Executive shall have the right, on the same basis as other senior executives of the
Company, to participate in and to receive benefits under any of the Company’s employee benefit plans, as such plans may be modified from time to time. 
  
 (c) Performance Bonus: Executive shall have the opportunity to earn a performance bonus in accordance with the Company’s Performance Bonus
Plan, as such plan may be modified over time. Pursuant to the Performance Bonus Plan, Executive will have a target bonus for meeting established performance objectives. The target bonus at the level of meeting (and not performing at a higher or
lower threshold) shall be expressed as a multiple of Executive’s Base Salary (the “Target Bonus”). 
  
 4. Equity Compensation Grants: All equity compensation grants, including, but not limited to, stock options and restricted stock (“Equity
Grants”) shall be governed by the terms of an agreement setting forth the terms and conditions of the Equity Grant. Notwithstanding any other provision to the contrary contained in any agreement evidencing any current or future Equity Grant
(and to the extent that such provisions are not already contained in such agreements precisely as set forth hereunder), each such agreement may incorporate this Agreement by reference and shall be deemed to include each of the additional provisions
set forth below. The rights provided by this Section 4 shall be in addition to any rights granted to Executive under any such agreement. 
  
 (a) Acceleration of Equity Compensation Vesting Upon Non-Assumption. In the event of a Change in Control, each Equity Grant held by Executive, to
the extent then outstanding, shall become fully vested and exercisable immediately prior to but conditioned upon the consummation of the Change in Control, except to the extent that the surviving, continuing, successor, or purchasing entity or
parent thereof, as the case may be (the “Acquiror”), (A) assumes or continues in effect the Company’s rights and obligations under such Equity Grant, (B) substitutes for such Equity Grant a substantially equivalent right for the
Acquiror’s stock or (C) replaces such Equity Grant with a cash incentive program pursuant to which Executive is to be paid for each share of the Company’s common stock subject to such option or award immediately prior to the consummation
of the Change in Control and in accordance with the same vesting schedule applicable to such Equity Grant (including any subsequent acceleration of vesting determined under any other Section of this Agreement) an amount equal to the excess of the
fair market value of the consideration paid by the Acquiror for each share of the common stock of the Company outstanding immediately prior to the consummation of the Change in Control over the per share exercise price of such option. 
  
 (b) Acceleration of Equity Compensation Grant Vesting Upon Involuntary
Termination During a Change in Control Period. If Executive’s employment with the Company terminates as a result of an Involuntary Termination occurring during the Change in Control Period, then (A) each Equity Grant held by Executive, to
the extent then outstanding, shall become fully vested and exercisable (and any forfeiture provision shall lapse) in full as of the later of the date of Executive’s termination of employment or the last day following Executive’s execution
of the Release on which Executive may revoke such Release under its terms and shall remain exercisable in full until the first to occur of the expiration of a period of three months following the date on which Executive’s employment terminated
or the expiration of the term of such Equity Grant. 

 (c) Acceleration of Equity Compensation Grant Vesting Upon Death. If Executive’s employment
with the Company terminates due to Executive’s death, then (A) each Equity Grant held by Executive, to the extent then outstanding, shall become fully vested and exercisable (and any forfeiture provision shall lapse) in full as of the date of
Executive’s death. The Equity Grants shall be exercisable by the estate of the Executive in accordance with the time periods and procedures set forth in the Equity Grant agreement. 
  
 5. Effect of Termination of Employment. 
  
 (a) Voluntary Termination, Death or Disability: In the event of Executive’s voluntary termination from
employment with the Company, Executive shall be entitled to no compensation or benefits from the Company other than those earned under Section 3 through the date of his termination and, in the case of each stock option, restricted stock award or
other Company stock-based award granted to Executive, the extent to which such awards are vested through the date of his termination. In the event that Executive’s employment terminates as a result of his/her death or disability, Executive
shall be entitled to a pro-rata share of the Target Bonus (presuming performance meeting, but not exceeding, target performance goals) in addition to all compensation and benefits earned under Section 3 through the date of termination. 

 
 (b) Termination for Cause: If Executive’s employment is
terminated by the Company for Cause, Executive shall be entitled to no compensation or benefits from the Company other than those earned under Section 3 through the date of his termination and, in the case of each stock option, restricted stock
award or other Company stock-based award granted to Executive, the extent to which such awards are vested through the date of his termination. In the event that the Company terminates Executive’s employment for Cause, the Company shall provide
written notice to Executive of that fact prior to, or concurrently with, the termination of employment. Failure to provide written notice that the Company contends that the termination is for Cause shall constitute a waiver of any contention that
the termination was for Cause, and the termination shall be irrebuttably presumed to be an Involuntary Termination. However, if, within thirty days following the termination, the Company first discovers facts that would have established
“Cause” for termination, and those facts were not known by the Company at the time of the termination, then the Company shall provide Executive with written notice, including the facts establishing that the purported “Cause” was
not known at the time of the termination, and the Company will pay no severance. 
  
 (c) Involuntary Termination During Change in Control Period: If Executive’s employment with the Company terminates as a result of a Change in Control Period Involuntary Termination, then, in addition to
any other benefits described in this Agreement, Executive shall receive the following: 
  
 (i) all compensation and benefits earned under Section 3 through the date of Executive’s termination of employment; 

 (ii) a pro-rata share of the Target Bonus if, and only to the extent that, the Company has met its
target performance objectives for the year to date; 
  
 (iii) a
lump sum payment equivalent to [three years’ (for CEO and President)][two years’ (for all other executive officers)] Base Salary (as it was in effect immediately prior to the Change in Control); 
  
 (iv) a lump sum payment equivalent to the greater of: (i) [three times
(for CEO and President)][two times (for all other executive officers)] the bonus paid under the Performance Bonus Plan for the year immediately prior to the year in which the Change in Control occurred; or (ii) [three years’ (for
CEO and President)][two years’ (for all other executive officers)] Target Bonus under the Performance Bonus Plan in effect immediately prior to the year in which the Change in Control occurs; and 
  
 (v) reimbursement for the cost of medical, life and disability insurance
coverage at a level equivalent to that provided by the Company for a period of the earlier of: (i) [three years (for CEO and President)][two years (for all other executive officers)]; or (ii) the time Executive begins alternative
employment. It shall be the obligation of Executive to inform the Company that new employment has been obtained. 
  
 The amount payable to Executive under subsections (ii) through (iv), above, shall be paid to Executive in a lump sum on the later of thirty (30) days following the later
of Executive’s termination of employment or the last day following Executive’s execution of the Release or on which Executive may revoke such Release under its terms. The amounts payable under subsection (v) shall be paid monthly during
the reimbursement period, provided that Executive has executed the Release and any revocation period has run. 
  
 (d) Equalization Payment: If Executive’s employment with the Company terminates as a result of an Involuntary Termination occurring during the
Change in Control Period, then, in addition to the benefits described in subsection (c) above (the “Change in Control Severance Benefits”), the Company will also pay Executive a tax equalization payment, which shall be in an amount which,
when added to the other amounts payable, will place Executive in the same after-tax position as if the excise tax penalty of Section 4999 of the Internal Revenue Code of 1986, as amended (the “Code”), or any successor statue of similar
import, did not apply to any of the Change in Control Severance Benefits. The amount of this tax equalization payment shall be determined by Company’s independent accountants and shall be payable to Executive at the same time as the other
severance payments under this Section 5. The Compensation Committee of the Board of Directors will review the appropriateness of any such payment for each calendar year beginning on or after January 1, 2005 and will determine whether to maintain
this provision by resolution adopted on or before December 31 of the preceding year. In the event no such resolution is adopted, this equalization payment provision will remain in effect. However, in the event that the Change in Control Severance
Benefits exceed the minimum amount required to impose the excise tax penalty of Section 4999 of the Code (the “Threshold 280G Amount”) by an amount equal to or less than ten percent of the Threshold 280G Amount, then the Change in Control
Severance Benefits shall be reduced so that they total one dollar less than the Threshold 280G Amount. 

 (e) Termination without Cause in the Absence of Change in Control: In the event that
Executive’s employment terminates as a result of a Non Change in Control Period Involuntary Termination, then Executive shall receive the following benefits: 
  
 (i) all compensation and benefits earned under Section 3 through the date of Executive’s termination of employment;

  
 (ii) a pro-rata share of the Target Bonus if, and only to the
extent that, the Company has met its target performance objectives for the year to date; 
  
 (iii) a lump sum payment equivalent to [two years’ (for CEO only)][one year’s (for all other executive officers)] Base Salary; and 
  
 (iv) a lump sum payment equivalent to the greater of: (i) [two times (for CEO only)][one times (for all other
executive officers] the bonus paid under the Performance Bonus Plan for the year immediately prior to the year in which the Non Change in Control Period Termination occurred; or (ii) [two years’ (for CEO only)][one year’s
(for all other executive officers)] Target Bonus under the Performance Bonus Plan in effect immediately prior to the year in which the Non Change in Control Period Termination occurs: and 
  
 (v) reimbursement for the cost of medical, life and disability insurance
coverage at a level equivalent to that provided by the Company for a period of the earlier of: (i) [two years (for CEO only)][one year (for all other executive officers)]; or (ii) the time Executive begins alternative employment. It
shall be the obligation of Executive to inform the Company that new employment has been obtained. 
  
 The amount payable to Executive under subsections (ii) through (iv) above shall be paid to Executive in a lump sum within thirty (30) days following the later of Executive’s termination of employment or the last
day following Executive’s execution of the Release or on which Executive may revoke such Release under its terms. The amounts payable under subsection (iv) shall be paid monthly during the reimbursement period, provided that Executive has
executed the Release and any revocation period has run. 
  
 (e)
Resignation from Positions: In the event that Executive’s employment with the Company is terminated for any reason, on the effective date of the termination Executive shall simultaneously resign from each position he holds on the Board
and/or the board of directors of any of the Company’s affiliated entities and any position Executive holds as an officer of the Company or any of the Company’s affiliated entities. 
  
 6. Certain Definitions: For the purposes of this Agreement, the
following capitalized terms shall have the meanings set forth below: 
  
 (a) “Cause” shall mean any of the following: 
  
 (i) Executive’s theft, dishonesty, willful misconduct, breach of fiduciary duty for personal profit, or falsification of any employment or Company records; 

 (ii) Executive’s willful violation of any law, rule, or regulation (other than traffic violations
or similar offenses) or final cease-and-desist order or commission of an act that involves moral turpitude; 
  
 (iii) Executive’s intentional failure to perform stated duties; 
  
 (iv) Executive’s improper disclosure of the Company’s confidential or proprietary information; 
  
 (v) any material breach by Executive of the Company’s Code of
Professional Conduct, which breach shall be deemed “material” if it results from an intentional act by Executive and has a material detrimental effect on the Company’s reputation or business; or 
  
 (vi) any material breach by Executive of this Agreement, which breach, if
curable, is not cured within thirty (30) days following written notice of such breach from the Company. 
  
 (b) “Change in Control” shall mean the occurrence of any of the following events: 
  
 (i) (X) any “person” (as such term is used in Sections 13(d) and
14(d) of the Securities Exchange Act of 1934, as amended) becomes the “beneficial owner” (as defined in Rule 13d-3 under said Act), directly or indirectly, of securities of the Company representing more than fifty percent (50%) of the
total combined voting power represented by the Company’s then outstanding voting securities other than the acquisition of the Company’s Common Stock by a Company-sponsored employee benefit plan or through the issuance of shares sold
directly by the Company to a single acquiror; or (Y) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) becomes the “beneficial owner” (as defined in Rule 13d-3
under said Act), directly or indirectly, of securities of the Company representing less than fifty percent (50%) of the total combined voting power represented by the Company’s then outstanding voting securities, but in connection with the
person’s acquisition of securities the person acquires the right to terminate the employment of all or a portion of the Company’s management team; 
  
 (ii) the Company is party to a merger or consolidation which results in the holders of the voting securities of the Company outstanding immediately prior
thereto failing to retain immediately after such merger or consolidation direct or indirect beneficial ownership of more than fifty percent (50%) of the total combined voting power of the securities entitled to vote generally in the election of
directors of the Company or the surviving entity outstanding immediately after such merger or consolidation; 
  
 (iii) a change in the composition of the Board occurring within a period of twenty-four (24) consecutive months, as a result of which fewer than a
majority of the directors are Incumbent Directors; 
  
 (iv)
effectiveness of an agreement for the sale, lease or disposition by the Company of all or substantially all of the Company’s assets; or 

 (v) a liquidation or dissolution of the Company. 
  
 The Incumbent Directors shall have the right to determine whether multiple sales or exchanges
of the voting stock of the Company, which, in the aggregate, would result in a Change of Control, are related, and its determination shall be final, binding and conclusive. 
  
 (c) “Change in Control Period” shall mean the period commencing on the earlier of: (i) sixty (60) days
prior to the date of consummation of the Change in Control;(ii) the date of the first public announcement of a definitive agreement that would result in a Change in Control (even though still subject to approval by the Company’s stockholders
and other conditions and contingencies); or (iii) the date of the public announcement of a tender offer that is not approved by the Incumbent Directors and ending on the two year anniversary date of the consummation of the Change in Control.

  
 (d) “Change in Control Period Good Reason”
shall mean any of the following conditions, first occurring during a Change in Control Period: 
  
 (i) a decrease in Executive’s Base Salary and/or a decrease in Executive’s Target Bonus (as a multiple of Executive’s Base Salary) under
the Performance Bonus Plan or employee benefits other than as part of any across-the-board reduction applying to all senior executives and not resulting in those senior executives receiving lesser benefits than similarly situated executives of an
acquiror; 
  
 (ii) a material, adverse change in Executive’s
title, authority, responsibilities or duties, as measured against Executive’s title, authority, responsibilities or duties immediately prior to such change. For purposes of this subsection, in addition to any other change in title, authority,
responsibilities or duties, the following changes shall constitute an event of “Good Reason”: (i) an individual who held a position in an independent, publicly held company prior to the Change in Control holds a position in a subsidiary
company following the Change in Control; and (ii) an individual who reported directly to the COO, CEO or Board of Directors of a publicly held company prior to the Change in Control reports to an individual or entity that is not, respectively, the
COO, CEO or Board of Directors of a publicly held company. 
  
 (iii) the relocation of Executive’s principle workplace to a location greater than fifty (50) miles from the prior workplace; 
  
 (iv) any material breach by the Company of any provision of this Agreement, which breach is not cured within thirty (30) days following written notice of
such breach from Executive; 
  
 (v) any failure of the Company to
obtain the assumption of this Agreement by any successor or assign of the Company; or 

 (vi) any purported termination of Executive’s employment for “material breach of
contract” which is purportedly effected without providing the “cure” period, if applicable, described in Section 6(a)(vi), above. 
  
 (e) “Non Change in Control Period Good Reason” shall mean any of the following conditions first occurring outside of a Change in Control
Period and occurring without Executive’s written consent: 
  
 (i) a decrease in Executive’s total cash compensation opportunity (adding Base Salary and Target Bonus) of greater than 20%; 
  
 (ii) a material, adverse change in Executive’s title, authority, responsibilities or duties, as measured against Executive’s title, authority,
responsibilities or duties immediately prior to such change. For purposes of this subsection, a material, adverse change shall not occur merely by a change in reporting relationship; or 
  
 (iii) any material breach by the Company of any provision of this Agreement, which breach is not cured within thirty (30)
days following written notice of such breach from Executive; 
  
 (f) “Incumbent Directors” shall mean members of the Board who either (i) are members of the Board as of the date hereof, or (ii) are elected, or nominated for election, to the Board with the affirmative vote of at least a
majority of the Incumbent Directors at the time of such election or nomination (but shall not include an individual whose election or nomination is in connection with an actual or threatened proxy contest relating to the election of members of the
Board). 
  
 (g) “Change in Control Period Involuntary
Termination” shall mean the occurrence of either of the following during a Change in Control Period: 
  
 (i) termination by the Company of Executive’s employment with the Company for any reason other than Cause; or 
  
 (ii) Executive’s resignation from employment for Change in Control
Period Good Reason within six (6) months following the occurrence of the event constituting Change in Control Period Good Reason. 
  
 For the purposes of any determination regarding the existence of Good Reason hereunder, any claim by Executive that Change in Control Period Good Reason exists shall be
presumed to be correct unless the Company establishes to the Board that Change in Control Period Good Reason does not exist, and the Board, acting in good faith, affirms such determination by a vote of not less than two-thirds of its entire
membership. The effective date of any Change in Control Period Involuntary Termination shall be the date of notification to the Executive of the termination of employment by the Company or the date of notification to the Company of the resignation
from employment by the Executive for Change in Control Period Good Reason. 

 (h) “Non Change in Control Period Involuntary Termination” shall mean the occurrence of
either of the following occurring outside a Change in Control Period: 
  
 (i) termination by the Company of Executive’s employment with the Company for any reason other than Cause; or 
  
 (ii) Executive’s resignation from employment for Non Change in Control Period Good Reason within six (6) months following the occurrence of the
event constituting Non Change in Control Period Good Reason. 
  
 For the purposes
of any determination regarding the existence of Non Change in Control Period Good Reason hereunder, Executive shall bear the burden of demonstrating that an event of Non Change in Control Period Good Reason has occurred. Only the Board, acting as a
majority, may determine that an event of Non Change in Control Period Good Reason has occurred; the Board must act within five business days of such notification, or the Executive’s claim shall be deemed valid. The effective date of any Non
Change in Control Period Involuntary Termination shall be the date of notification to the Executive of the termination of employment by the Company or the date of notification to the Company of the resignation from employment by the Executive for
Non Change in Control Period Good Reason. 
  
 (h)
“Release” shall mean a general release of all known and unknown claims against the Company and its affiliates and their stockholders, directors, officers, employees, agents, successors and assigns substantially in a form reasonably
acceptable to the Company. 
  
 7. Employee Inventions and
Proprietary Rights Assignment Agreement; Insider Trading Policy: Executive agrees to abide by the terms and conditions of the Company’s standard Employee Inventions and Proprietary Rights Assignment Agreement and the Company’s Insider
Trading Policy, as it may be amended from time to time. 
  
 8.
Agreement Not To Compete; Return of Company Property: Executive agrees that in the event of his termination at any time and for any reason, he shall not compete with the Company in any unfair manner, including, without limitation, using any
confidential or proprietary information of the Company to compete with the Company in any way. Upon termination of employment for any reason, Executive shall immediately deliver to the Company all documents, property, and other records of the
Company or any affiliate of the Company, and all copies thereof, within Executive’s possession, custody or control. Further, in the event that Executive’s employment is terminated as a result of his/her voluntary termination, Executive
agrees that for a period of one year following the date of termination he/she will not accept employment, or perform services as a consultant or independent contractor, for any of the following entities or their successors: Ameritrade, Charles
Schwab & Co., Fidelity Investments, Scottrade, Inc. or TD Waterhouse Group, Inc., 
  
 9. Non-Solicitation: Executive agrees that for a period of one year after the date of the termination of his employment for any reason, he shall not, either directly or indirectly, solicit the services, or
attempt to solicit the services, of any employee of the Company to any other person or entity. 

 10. Dispute Resolution: In the event of any dispute or claim relating to or arising out of this
Agreement (including, but not limited to, any claims of breach of contract, wrongful termination or age, sex, race or other discrimination), Executive and the Company agree that all such disputes shall be fully and finally resolved by binding
arbitration conducted by the American Arbitration Association in [city of primary residence],[state of primary residence] in accordance with its National Employment Dispute Resolution rules. Executive acknowledges that by accepting
this arbitration provision he is waiving any right to a jury trial in the event of such dispute. In connection with any such arbitration, the Company shall bear all costs not otherwise born by a plaintiff in a court proceeding. 
  
 11. Attorneys’ Fees: The prevailing party shall be entitled to
recover from the losing party its attorneys’ fees and costs incurred in any action brought to enforce any right arising out of this Agreement. 
  
 12. General. 
  
 (a) Successors and Assigns: The provisions of this Agreement shall inure to the benefit of and be binding upon the Company, Executive and each and
all of their respective heirs, legal representatives, successors and assigns. The duties, responsibilities and obligations of Executive under this Agreement shall be personal and not assignable or delegable by Executive in any manner whatsoever to
any person, corporation, partnership, firm, company, joint venture or other entity. Executive may not assign, transfer, convey, mortgage, pledge or in any other manner encumber the compensation or other benefits to be received by him or any rights
which he may have pursuant to the terms and provisions of this Agreement. 
  
 (b) Amendments; Waiver: No provision of this Agreement shall be modified, waived or discharged unless the modification, waiver or discharge is agreed to in writing and signed by Executive and by an authorized
officer of the Company. No waiver by either party of any breach of, or of compliance with, any condition or provision of this Agreement by the other party shall be considered a waiver of any other condition or provision or of the same condition or
provision at another time. 
  
 (c) Notices: Any notices to
be given pursuant to this Agreement by either party to the other party may be effected by personal delivery or by overnight delivery with receipt requested. Mailed notices shall be addressed to the parties at the addresses stated below, but each
party may change its or his address by written notice to the other in accordance with this Paragraph. 
  
 Mailed notices to Executive shall be addressed as follows: 
  

	
	
 
	  

	  

 Mailed notices to the Company shall be addressed as follows: 
  
 E*TRADE Financial Corporation 
 671 North Glebe Road 
 Arlington, VA 22203

 Attention: General Counsel 
  
 (d) Entire Agreement: This Agreement constitutes the entire employment agreement between Executive and the Company regarding the terms and
conditions of his employment, with the exception of (i) the agreement described in Section 7 and (ii) any stock option, restricted stock or other Company stock-based award agreements between Executive and the Company to the extent not modified by
this Agreement. This Agreement (including the documents described in (i) and (ii) herein) supersedes all prior negotiations, representations or agreements between Executive and the Company, whether written or oral, concerning Executive’s
employment by the Company. 
  
 (e) Withholding Taxes: All
payments made under this Agreement shall be subject to reduction to reflect taxes required to be withheld by law. 
  
 (f) Counterparts: This Agreement may be executed by the Company and Executive in counterparts, each of which shall be deemed an original and which
together shall constitute one instrument. 
  
 (g) Headings:
Each and all of the headings contained in this Agreement are for reference purposes only and shall not in any manner whatsoever affect the construction or interpretation of this Agreement or be deemed a part of this Agreement for any purpose
whatsoever. 
  
 (h) Savings Provision: To the extent that
any provision of this Agreement or any paragraph, term, provision, sentence, phrase, clause or word of this Agreement shall be found to be illegal or unenforceable for any reason, such paragraph, term, provision, sentence, phrase, clause or word
shall be modified or deleted in such a manner as to make this Agreement, as so modified, legal and enforceable under applicable laws. The remainder of this Agreement shall continue in full force and effect. 
  
 (i) Construction: The language of this Agreement and of each and every
paragraph, term and provision of this Agreement shall, in all cases, for any and all purposes, and in any and all circumstances whatsoever be construed as a whole, according to its fair meaning, not strictly for or against Executive or the Company,
and with no regard whatsoever to the identity or status of any person or persons who drafted all or any portion of this Agreement. 
  
 (j) Further Assurances: From time to time, at the Company’s request and without further consideration, Executive shall execute and deliver
such additional documents and take all such further action as reasonably requested by the Company to be necessary or desirable to make effective, in the most expeditious manner possible, the terms of this Agreement and to provide adequate assurance
of Executive’s due performance hereunder. 

 (k) Governing Law: Executive and the Company agree that this Agreement shall be interpreted in
accordance with and governed by the laws of the State of New York. 
  
 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date and year written below. 
  

					
	Date:	 	E*TRADE Financial Corporation
			
	 	 	By:	 	  

			
	Date:	 	 	 	 
	 	 	By:Form of Senior Indenture

 EXHIBIT 4.11 
  
 FORM OF INDENTURE TO BE ENTERED INTO 
  
 BETWEEN THE COMPANY AND A TRUSTEE TO BE NAMED 
  
 NUVELO, INC. 
  
 INDENTURE 
  
 U.S. BANK NATIONAL ASSOCIATION 
  
 TRUSTEE 
  
 Dated as of
                     , 2004 
  
 Senior Debt Securities 

 TABLE OF CONTENTS 
  

					
	 	  	 	  	PAGE

		
	 ARTICLE I    DEFINITIONS AND INCORPORATION BY REFERENCE
	  	2
			
	 Section 1.1
	  	 Definitions
	  	2
			
	 Section 1.2
	  	 Other Definitions
	  	6
			
	 Section 1.3
	  	 Incorporation by Reference of Trust Indenture Act
	  	6
			
	 Section 1.4
	  	 Rules of Construction
	  	6
		
	 ARTICLE II    THE SECURITIES
	  	7
			
	 Section 2.1
	  	 Issuable in Series
	  	7
			
	 Section 2.2
	  	 Establishment of Terms of Series of Securities
	  	7
			
	 Section 2.3
	  	 Execution and Authentication
	  	9
			
	 Section 2.4
	  	 Registrar and Paying Agent
	  	10
			
	 Section 2.5
	  	 Paying Agent to Hold Money in Trust
	  	11
			
	 Section 2.6
	  	 Securityholder Lists
	  	11
			
	 Section 2.7
	  	 Transfer and Exchange
	  	12
			
	 Section 2.8
	  	 Mutilated, Destroyed, Lost and Stolen Securities
	  	12
			
	 Section 2.9
	  	 Outstanding Securities
	  	13
			
	 Section 2.10
	  	 Treasury Securities
	  	13
			
	 Section 2.11
	  	 Temporary Securities
	  	13
			
	 Section 2.12
	  	 Cancellation
	  	14
			
	 Section 2.13
	  	 Defaulted Interest
	  	14
			
	 Section 2.14
	  	 Global Securities
	  	14
			
	 Section 2.15
	  	 CUSIP Numbers
	  	15
		
	 ARTICLE III    REDEMPTION
	  	16
			
	 Section 3.1
	  	 Notice to Trustee
	  	16
			
	 Section 3.2
	  	 Selection of Securities to be Redeemed
	  	16
			
	 Section 3.3
	  	 Notice of Redemption
	  	16
			
	 Section 3.4
	  	 Effect of Notice of Redemption
	  	17
			
	 Section 3.5
	  	 Deposit of Redemption Price
	  	17
			
	 Section 3.6
	  	 Securities Redeemed in Part
	  	17
		
	 ARTICLE IV    COVENANTS
	  	17
			
	 Section 4.1
	  	 Payment of Principal and Interest
	  	17

  

 -i- 

 TABLE OF CONTENTS 
 (CONTINUED) 
  

					
	 	  	 	  	PAGE

	 Section 4.2
	  	 SEC Reports
	  	17
			
	 Section 4.3
	  	 Compliance Certificate
	  	18
			
	 Section 4.4
	  	 Corporate Existence
	  	18
			
	 Section 4.5
	  	 Taxes
	  	18
		
	 ARTICLE V    SUCCESSORS
	  	18
			
	 Section 5.1
	  	 When Company May Merge, Etc
	  	18
			
	 Section 5.2
	  	 Successor Corporation Substituted
	  	19
		
	 ARTICLE VI    DEFAULTS AND REMEDIES
	  	19
			
	 Section 6.1
	  	 Events of Default
	  	19
			
	 Section 6.2
	  	 Acceleration of Maturity; Rescission and Annulment
	  	20
			
	 Section 6.3
	  	 Collection of Indebtedness and Suits for Enforcement by Trustee
	  	21
			
	 Section 6.4
	  	 Trustee May File Proofs of Claim
	  	22
			
	 Section 6.5
	  	 Trustee May Enforce Claims Without Possession of Securities
	  	23
			
	 Section 6.6
	  	 Application of Money Collected
	  	23
			
	 Section 6.7
	  	 Limitation on Suits
	  	23
			
	 Section 6.8
	  	 Unconditional Right of Holders to Receive Principal and Interest
	  	24
			
	 Section 6.9
	  	 Restoration of Rights and Remedies
	  	24
			
	 Section 6.10
	  	 Rights and Remedies Cumulative
	  	24
			
	 Section 6.11
	  	 Delay or Omission Not Waiver
	  	24
			
	 Section 6.12
	  	 Control by Holders
	  	25
			
	 Section 6.13
	  	 Waiver of Past Defaults
	  	25
			
	 Section 6.14
	  	 Undertaking for Costs
	  	25
		
	 ARTICLE VII    TRUSTEE
	  	26
			
	 Section 7.1
	  	 Duties of Trustee
	  	26
			
	 Section 7.2
	  	 Rights of Trustee
	  	27
			
	 Section 7.3
	  	 Individual Rights of Trustee
	  	28
			
	 Section 7.4
	  	 Trustee’s Disclaimer
	  	28
			
	 Section 7.5
	  	 Notice of Defaults
	  	28
			
	 Section 7.6
	  	 Reports by Trustee to Holders
	  	28

  

 -ii- 

 TABLE OF CONTENTS 
 (CONTINUED) 
  

					
	 	  	 	  	PAGE

	 Section 7.7
	  	 Compensation and Indemnity
	  	28
			
	 Section 7.8
	  	 Replacement of Trustee
	  	29
			
	 Section 7.9
	  	 Successor Trustee by Merger, etc
	  	30
			
	 Section 7.10
	  	 Eligibility; Disqualification
	  	30
			
	 Section 7.11
	  	 Preferential Collection of Claims Against Company
	  	30
		
	 ARTICLE VIII    SATISFACTION AND DISCHARGE; DEFEASANCE
	  	31
			
	 Section 8.1
	  	 Satisfaction and Discharge of Indenture
	  	31
			
	 Section 8.2
	  	 Application of Trust Funds; Indemnification
	  	32
			
	 Section 8.3
	  	 Legal Defeasance of Securities of any Series
	  	32
			
	 Section 8.4
	  	 Covenant Defeasance
	  	34
			
	 Section 8.5
	  	 Repayment to Company
	  	35
			
	 Section 8.6
	  	 Reinstatement
	  	35
		
	 ARTICLE IX    AMENDMENTS AND WAIVERS
	  	35
			
	 Section 9.1
	  	 Without Consent of Holders
	  	35
			
	 Section 9.2
	  	 With Consent of Holders
	  	36
			
	 Section 9.3
	  	 Limitations
	  	36
			
	 Section 9.4
	  	 Compliance with Trust Indenture Act
	  	37
			
	 Section 9.5
	  	 Revocation and Effect of Consents
	  	37
			
	 Section 9.6
	  	 Notation on or Exchange of Securities
	  	37
			
	 Section 9.7
	  	 Trustee Protected
	  	38
		
	 ARTICLE X    MISCELLANEOUS
	  	38
			
	 Section 10.1
	  	 Trust Indenture Act Controls
	  	38
			
	 Section 10.2
	  	 Notices
	  	38
			
	 Section 10.3
	  	 Communication by Holders with Other Holders
	  	39
			
	 Section 10.4
	  	 Certificate and Opinion as to Conditions Precedent
	  	39
			
	 Section 10.5
	  	 Statements Required in Certificate or Opinion
	  	39
			
	 Section 10.6
	  	 Rules by Trustee and Agents
	  	40
			
	 Section 10.7
	  	 Legal Holidays
	  	40
			
	 Section 10.8
	  	 No Recourse Against Others
	  	40
			
	 Section 10.9
	  	 Counterparts
	  	40

  

 -iii- 

 TABLE OF CONTENTS 
 (CONTINUED) 
  

					
	 	  	 	  	PAGE

	 Section 10.10
	  	 Governing Laws
	  	40
			
	 Section 10.11
	  	 No Adverse Interpretation of Other Agreements
	  	40
			
	 Section 10.12
	  	 Successors
	  	40
			
	 Section 10.13
	  	 Severability
	  	41
			
	 Section 10.14
	  	 Table of Contents, Headings, Etc
	  	41
			
	 Section 10.15
	  	 Securities in a Foreign Currency or in ECU
	  	41
			
	 Section 10.16
	  	 Judgment Currency
	  	42
		
	 ARTICLE XI    SINKING FUNDS
	  	42
			
	 Section 11.1
	  	 Applicability of Article
	  	42
			
	 Section 11.2
	  	 Satisfaction of Sinking Fund Payments with Securities
	  	43
			
	 Section 11.3
	  	 Redemption of Securities for Sinking Fund
	  	43

  

 -iv- 

 NUVELO, INC. 
 Reconciliation and tie between Trust Indenture Act of 1939 and 
 Indenture, dated as of
                    , 2004 
  

			
	 Section 310(a)(1)
	  	7.10
	 (a)(2)
	  	7.10
	 (a)(3)
	  	Not Applicable
	 (a)(4)
	  	Not Applicable
	 (a)(5)
	  	7.10
	 (b)
	  	7.10
	 Section 311(a)
	  	7.11
	 (b)
	  	7.11
	 (c)
	  	Not Applicable
	 Section 312(a)
	  	2.6
	 (b)
	  	10.3
	 (c)
	  	10.3
	 Section 313(a)
	  	7.6
	 (b)(1)
	  	7.6
	 (b)(2)
	  	7.6
	 (c)(1)
	  	7.6
	 (d)
	  	7.6
	 Section 314(a)
	  	4.2, 10.5
	 (b)
	  	Not Applicable
	 (c)(1)
	  	10.4
	 (c)(2)
	  	10.4
	 (c)(3)
	  	Not Applicable
	 (d)
	  	Not Applicable
	 (e)
	  	10.5
	 (f)
	  	Not Applicable
	 Section 315(a)
	  	7.1
	 (b)
	  	7.5
	 (c)
	  	7.1
	 (d)
	  	7.1
	 (e)
	  	6.14
	 Section 316(a)
	  	2.10
	 (a)(1)(A)
	  	6.12
	 (a)(1)(B)
	  	6.13
	 (b)
	  	6.8
	 Section 317(a)(1)
	  	6.3
	 (a)(2)
	  	6.4
	 (b)
	  	2.5
	 Section 318(a)
	  	10.1

  

	Note:	This reconciliation and tie shall not, for any purpose, be deemed to be part of the Indenture. 

  

 1. 

 INDENTURE, dated as of
                        , 2004 between NUVELO, INC., a Delaware corporation
(“Company”), and U.S. BANK NATIONAL ASSOCIATION, a national banking association (“Trustee”). 
  
 Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders of the Securities
issued under this Indenture. 
  
 ARTICLE I 
  
 DEFINITIONS AND INCORPORATION BY REFERENCE 
  

	Section	 1.1 Definitions. 

  
 “Additional Amounts” means any additional amounts which are required hereby or by any Security, under circumstances specified herein or therein,
to be paid by the Company in respect of certain taxes imposed on Holders specified therein and which are owing to such Holders. 
  
 “Affiliate” of any specified person means any other person directly or indirectly controlling or controlled by or under direct or indirect
common control with such specified person. For the purposes of this definition, “control” (including, with correlative meanings, the terms “controlled by” and “under common control with”), as used with respect to any
person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through the ownership of voting securities or by agreement or otherwise. 
  
 “Agent” means any Registrar, Paying Agent, Service Agent or
authenticating agent. 
  
 “Authorized Newspaper” means a
newspaper in an official language of the country of publication customarily published at least once a day for at least five days in each calendar week and of general circulation in the place in connection with which the term is used. If it shall be
impractical to make any publication of any notice required hereby in an Authorized Newspaper, any publication or other notice in lieu thereof that is made or given by the Trustee shall constitute a sufficient publication of such notice. 

 
 “Bearer” means anyone in possession from time to time of a
Bearer Security. 
  
 “Bearer Security” means any
Security, including any interest coupon appertaining thereto, that does not provide for the identification of the Holder thereof. 
  
 “Board of Directors” means the Board of Directors of the Company or any duly authorized committee thereof. 
  
 “Board Resolution” means a copy of a resolution certified by the
Secretary or an Assistant Secretary of the Company to have been adopted by the Board of Directors or pursuant to authorization by the Board of Directors and to be in full force and effect on the date of the certificate and delivered to the Trustee.

  

 2. 

 “Business Day” means, unless otherwise provided by Board Resolution, Officers’ Certificate
or supplemental indenture hereto for a particular Series, any day except a Saturday, Sunday or a legal holiday in The City of New York or the City of San Francisco on which banking institutions are authorized or required by law, regulation or
executive order to close. 
  
 “Company” means the party
named as such above until a successor replaces it and thereafter means the successor. 
  
 “Company Order” means a written order signed in the name of the Company by two Officers, one of whom must be the Company’s chief executive officer, chief financial officer or principal accounting
officer. 
  
 “Company Request” means a written request
signed in the name of the Company by its Chairman of the Board, a President or a Vice President, and by its Treasurer, an Assistant Treasurer, its Secretary or an Assistant Secretary, and delivered to the Trustee. 
  
 “Corporate Trust Office” means the office of the Trustee at which
at any particular time its corporate trust business shall be principally administered. 
  
 “Default” means any event which is, or after notice or passage of time would be, an Event of Default. 
  
 “Depository” means, with respect to the Securities of any Series issuable or issued in whole or in part in the form of one or more Global
Securities, the person designated as Depository for such Series by the Company, which Depository shall be a clearing agency registered under the Exchange Act; and if at any time there is more than one such person, “Depository” as used with
respect to the Securities of any Series shall mean the Depository with respect to the Securities of such Series. 
  
 “Discount Security” means any Security that provides for an amount less than the stated principal amount thereof to be due and payable upon
declaration of acceleration of the maturity thereof pursuant to Section 6.2. 
  
 “Dollars” means the currency of The United States of America. 
  
 “ECU” means the European Currency Unit as determined by the Commission of the European Union. 
  
 “Exchange Act” means the Securities Exchange Act of 1934, as
amended. 
  
 “Foreign Currency” means any currency or
currency unit issued by a government other than the government of The United States of America. 
  

 3. 

 “Foreign Government Obligations” means with respect to Securities of any Series that are
denominated in a Foreign Currency, (i) direct obligations of the government that issued or caused to be issued such currency for the payment of which obligations its full faith and credit is pledged or (ii) obligations of a person controlled or
supervised by or acting as an agency or instrumentality of such government the timely payment of which is unconditionally guaranteed as a full faith and credit obligation by such government, which, in either case under clauses (i) or (ii), are not
callable or redeemable at the option of the issuer thereof. 
  
 “Global Security” or “Global Securities” means a Security or Securities, as the case may be, in the form established pursuant to Section 2.2 evidencing all or part of a Series of Securities, issued to the Depository for
such Series or its nominee, and registered in the name of such Depository or nominee. 
  
 “Holder” or “Securityholder” means a person in whose name a Security is registered or the holder of a Bearer Security. 
  
 “Indenture” means this Indenture as amended from time to time and shall include the form and terms of particular
Series of Securities established as contemplated hereunder. 
  
 “interest” with respect to any Discount Security which by its terms bears interest only after Maturity, means interest payable after Maturity. 
  
 “Maturity,” when used with respect to any Security or installment of principal thereof, means the date on which
the principal of such Security or such installment of principal becomes due and payable as therein or herein provided, whether at the Stated Maturity or by declaration of acceleration, call for redemption, notice of option to elect repayment or
otherwise. 
  
 “Officer” means the Chairman of the
Board, any President, any Vice-President, the Treasurer, the Secretary, any Assistant Treasurer or any Assistant Secretary of the Company. 
  
 “Officers’ Certificate” means a certificate signed by two Officers, one of whom must be the Company’s principal executive officer,
principal financial officer or principal accounting officer. 
  
 “Opinion of Counsel” means a written opinion of legal counsel who is acceptable to the Trustee. The counsel may be an employee of or counsel to the Company. 
  
 “person” means any individual, corporation, partnership, joint venture, association, limited liability company,
joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof. 
  
 “principal” of a Security means the principal of the Security plus, when appropriate, the premium, if any, on, and any Additional Amounts in
respect of, the Security. 
  
 “Responsible Officer”
means any officer of the Trustee in its Corporate Trust Office and also means, with respect to a particular corporate trust matter, any other officer to whom any corporate trust matter is referred because of his or her knowledge of and familiarity
with a particular subject. 
  

 4. 

 “SEC” means the Securities and Exchange Commission. 
  
 “Securities” means the debentures, notes or other debt instruments
of the Company of any Series authenticated and delivered under this Indenture. 
  
 “Series” or “Series of Securities” means each series of debentures, notes or other debt instruments of the Company created pursuant to Sections 2.1 and 2.2 hereof. 
  
 “Stated Maturity” when used with respect to any Security or any
installment of principal thereof or interest thereon, means the date specified in such Security as the fixed date on which the principal of such Security or such installment of principal or interest is due and payable. 
  
 “Subsidiary” of any specified person means any corporation of which
at least a majority of the outstanding stock having by the terms thereof ordinary voting power for the election of directors of such corporation (irrespective of whether or not at the time stock of any other class or classes of such corporation
shall have or might have voting power by reason of the happening of any contingency) is at the time directly or indirectly owned by such person, or by one or more other Subsidiaries, or by such person and one or more other Subsidiaries. 

 
 “TIA” means the Trust Indenture Act of 1939 (15 U.S. Code
Sections 77aaa-77bbbb) as in effect on the date of this Indenture; provided, however, that in the event the Trust Indenture Act of 1939 is amended after such date, “TIA” means, to the extent required by any such amendment, the Trust
Indenture Act as so amended. 
  
 “Trustee” means the
person named as the “Trustee” in the first paragraph of this instrument until a successor Trustee shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean or include each
person who is then a Trustee hereunder, and if at any time there is more than one such person, “Trustee” as used with respect to the Securities of any Series shall mean the Trustee with respect to Securities of that Series. 
  
 “U.S. Government Obligations” means securities which are (i) direct
obligations of The United States of America for the payment of which its full faith and credit is pledged or (ii) obligations of a person controlled or supervised by and acting as an agency or instrumentality of The United States of America the
payment of which is unconditionally guaranteed as a full faith and credit obligation by The United States of America, and which in the case of (i) and (ii) are not callable or redeemable at the option of the issuer thereof, and shall also include a
depository receipt issued by a bank or trust company as custodian with respect to any such U.S. Government Obligation or a specific payment of interest on or principal of any such U.S. Government Obligation held by such custodian for the account of
the holder of a depository receipt, provided that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder of such depository receipt from any amount received by the custodian in
respect of the U.S. Government Obligation evidenced by such depository receipt. 
  

 5. 

	Section	 1.2 Other Definitions. 

  

			
	 TERM

	  	DEFINED IN
SECTION

	 “Bankruptcy Law”
	  	  6.1  
	 “Custodian”
	  	  6.1  
	 “Event of Default”
	  	  6.1  
	 “Journal”
	  	10.15
	 “Judgment Currency”
	  	10.16
	 “Legal Holiday”  
	  	10.7  
	 “mandatory sinking fund payment”
	  	11.1  
	 “Market Exchange Rate”
	  	10.15
	 “New York Banking Day”
	  	10.16
	 “optional sinking fund payment”
	  	11.1  
	 “Paying Agent”
	  	  2.4  
	 “Registrar”
	  	  2.4  
	 “Required Currency”
	  	10.16
	 “Service Agent”
	  	  2.4  
	 “successor person”
	  	  5.1  

  

	Section	 1.3 Incorporation by Reference of Trust Indenture Act. 

  
 Whenever this Indenture refers to a provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture. The following
TIA terms used in this Indenture have the following meanings: 
  
 “Commission” means the SEC. 
  
 “indenture
securities” means the Securities. 
  
 “indenture
security holder” means a Securityholder. 
  
 “indenture
to be qualified” means this Indenture. 
  
 “indenture
trustee” or “institutional trustee” means the Trustee. 
  
 “obligor” on the indenture securities means the Company and any successor obligor upon the Securities. 
  
 All other terms used in this Indenture that are defined by the TIA, defined by TIA reference to another statute or defined by SEC rule under the TIA and
not otherwise defined herein are used herein as so defined. 
  

	Section	 1.4 Rules of Construction. 

  
 Unless the context otherwise requires: 
  
 (a) a term has the meaning assigned to it; 
  

 6. 

 (b) an accounting term not otherwise defined has the meaning assigned to it in
accordance with generally accepted accounting principles; 
  
 (c) references to “generally accepted accounting principles” shall mean generally accepted accounting principles in effect as of the time when and for the period as to which such accounting principles
are to be applied; 
  
 (d) “or”
is not exclusive; 
  
 (e) words in the
singular include the plural, and in the plural include the singular; and 
  
 (f) provisions apply to successive events and transactions. 
  
 ARTICLE II 
  
 THE SECURITIES 
  

	Section	 2.1 Issuable in Series. 

  
 The aggregate principal amount of Securities that may be authenticated and delivered under this Indenture is unlimited. The Securities may be issued in
one or more Series. All Securities of a Series shall be identical except as may be set forth in a Board Resolution, a supplemental indenture or an Officers’ Certificate detailing the adoption of the terms thereof pursuant to the authority
granted under a Board Resolution. In the case of Securities of a Series to be issued from time to time, the Board Resolution, Officers’ Certificate or supplemental indenture may provide for the method by which specified terms (such as interest
rate, maturity date, record date or date from which interest shall accrue) are to be determined. Securities may differ between Series in respect of any matters, provided that all Series of Securities shall be equally and ratably entitled to the
benefits of the Indenture. 
  

	Section	 2.2 Establishment of Terms of Series of Securities. 

  
 At or prior to the issuance of any Securities within a Series, the following shall be established (as to the Series generally, in the case of Subsection
2.2.1 and either as to such Securities within the Series or as to the Series generally in the case of Subsections 2.2.2 through 2.2.22) by a Board Resolution, a supplemental indenture or an Officers’ Certificate pursuant to authority granted
under a Board Resolution: 
  
 2.2.1 the
title of the Series (which shall distinguish the Securities of that particular Series from the Securities of any other Series); 
  
 2.2.2 the price or prices (expressed as a percentage of the principal amount thereof) at which the Securities of the Series will be
issued; 
  

 7. 

 2.2.3 any limit upon the aggregate principal amount of the Securities of the
Series which may be authenticated and delivered under this Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of the Series pursuant to Section 2.7, 2.8,
2.11, 3.6 or 9.6); 
  
 2.2.4 the date or
dates on which the principal of the Securities of the Series is payable; 
  
 2.2.5 the rate or rates (which may be fixed or variable) per annum or, if applicable, the method used to determine such rate or rates (including, but not limited to, any commodity, commodity index, stock
exchange index or financial index) at which the Securities of the Series shall bear interest, if any, the date or dates from which such interest, if any, shall accrue, the date or dates on which such interest, if any, shall commence and be payable
and any regular record date for the interest payable on any interest payment date; 
  
 2.2.6 the place or places where the principal of and interest, if any, on the Securities of the Series shall be payable, or the
method of such payment, if by wire transfer, mail or other means; 
  
 2.2.7 if applicable, the period or periods within which, the price or prices at which and the terms and conditions upon which the Securities of the Series may be redeemed, in whole or in part, at the option of
the Company; 
  
 2.2.8 the obligation, if
any, of the Company to redeem or purchase the Securities of the Series pursuant to any sinking fund or analogous provisions or at the option of a Holder thereof and the period or periods within which, the price or prices at which and the terms and
conditions upon which Securities of the Series shall be redeemed or purchased, in whole or in part, pursuant to such obligation; 
  
 2.2.9 the dates, if any, on which and the price or prices at which the Securities of the Series will be repurchased by the Company
at the option of the Holders thereof and other detailed terms and provisions of such repurchase obligations; 
  
 2.2.10 if other than denominations of $1,000 and any integral multiple thereof, the denominations in which the Securities of the
Series shall be issuable; 
  
 2.2.11 the
forms of the Securities of the Series in bearer or fully registered form (and, if in fully registered form, whether the Securities will be issuable as Global Securities); 
  
 2.2.12 if other than the principal amount thereof, the portion of the principal amount of the
Securities of the Series that shall be payable upon declaration of acceleration of the maturity thereof pursuant to Section 6.2; 
  
 2.2.13 the currency of denomination of the Securities of the Series, which may be Dollars or any Foreign Currency, including, but
not limited to, the ECU, and if such currency of denomination is a composite currency other than the ECU, the agency or organization, if any, responsible for overseeing such composite currency; 
  

 8. 

 2.2.14 the designation of the currency, currencies or currency units in which
payment of the principal of and interest, if any, on the Securities of the Series will be made; 
  
 2.2.15 if payments of principal of or interest, if any, on the Securities of the Series are to be made in one or more currencies or
currency units other than that or those in which such Securities are denominated, the manner in which the exchange rate with respect to such payments will be determined; 
  
 2.2.16 the manner in which the amounts of payment of principal of or interest, if any, on the
Securities of the Series will be determined, if such amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity index, stock exchange index or financial index; 
  
 2.2.17 the provisions, if any, relating to any
security provided for the Securities of the Series; 
  
 2.2.18 if the holders of Securities of the Series may convert or exchange the Securities into or for securities of the Issuer or of other entities or other property, the period or periods within which, the rate or rates at which and
the terms and conditions upon which Securities of the Series may be converted or exchanged, in whole or in part; 
  
 2.2.19 any addition to or change in the Events of Default which applies to any Securities of the Series and any change in the right
of the Trustee or the requisite Holders of such Securities to declare the principal amount thereof due and payable pursuant to Section 6.2; 
  
 2.2.20 any addition to or change in the covenants set forth in Articles IV or V which applies to Securities of the Series;

  
 2.2.21 any other terms of the
Securities of the Series (which terms shall not be inconsistent with the provisions of this Indenture, except as permitted by Section 9.1, but which may modify or delete any provision of this Indenture insofar as it applies to such Series); and

  
 2.2.22 any depositories, interest rate
calculation agents, exchange rate calculation agents or other agents with respect to Securities of such Series if other than those appointed herein. 
  
 All Securities of any one Series need not be issued at the same time and may be issued from time to time, consistent with the terms of this Indenture, if
so provided by or pursuant to the Board Resolution, supplemental indenture or Officers’ Certificate referred to above, and the authorized principal amount of any Series may not be increased to provide for issuances of additional Securities of
such Series, unless otherwise provided in such Board Resolution, supplemental indenture or Officers’ Certificate. 
  

	Section	 2.3 Execution and Authentication. 

  
 Two Officers shall sign the Securities for the Company by manual or facsimile signature. 
  

 9. 

 If an Officer whose signature is on a Security no longer holds that office at the time the Security is
authenticated, the Security shall nevertheless be valid. 
  
 A
Security shall not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. The signature shall be conclusive evidence that the Security has been authenticated under this Indenture. 
  
 The Trustee shall at any time, and from time to time, authenticate Securities
for original issue in the principal amount provided in the Board Resolution, supplemental indenture hereto or Officers’ Certificate, upon receipt by the Trustee of a Company Order. Such Company Order may authorize authentication and delivery
pursuant to oral or electronic instructions from the Company or its duly authorized agent or agents, which oral instructions shall be promptly confirmed in writing. Each Security shall be dated the date of its authentication unless otherwise
provided by a Board Resolution, a supplemental indenture hereto or an Officers’ Certificate. 
  
 The aggregate principal amount of Securities of any Series outstanding at any time may not exceed any limit upon the maximum principal amount for such
Series set forth in the Board Resolution, supplemental indenture hereto or Officers’ Certificate delivered pursuant to Section 2.2, except as provided in Section 2.8. 
  
 Prior to the issuance of Securities of any Series, the Trustee shall have received and (subject to Section 7.2) shall be
fully protected in relying on: (a) the Board Resolution, supplemental indenture hereto or Officers’ Certificate establishing the form of the Securities of that Series or of Securities within that Series and the terms of the Securities of that
Series or of Securities within that Series, (b) an Officers’ Certificate complying with Section 10.4, and (c) an Opinion of Counsel complying with Section 10.4. 
  
 The Trustee shall have the right to decline to authenticate and deliver any Securities of such Series: (a) if the Trustee,
being advised by counsel, determines that such action may not lawfully be taken; or (b) if the Trustee in good faith by its board of directors or trustees, executive committee or a trust committee of directors and/or vice-presidents shall determine
that such action would expose the Trustee to personal liability to Holders of any then outstanding Series of Securities. 
  
 The Trustee may appoint an authenticating agent acceptable to the Company to authenticate Securities. An authenticating agent may authenticate Securities
whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such agent. An authenticating agent has the same rights as an Agent to deal with the Company or an Affiliate. 
  

	Section	 2.4 Registrar and Paying Agent. 

  
 The Company shall maintain, with respect to each Series of Securities, at the place or places specified with respect to such Series pursuant to Section
2.2, an office or agency where Securities of such Series may be presented or surrendered for payment (“Paying Agent”), where Securities of such Series may be surrendered for registration of transfer or exchange (“Registrar”) and
where notices and demands to or upon the Company in respect of the Securities of such Series and this Indenture may be served (“Service Agent”). The Registrar shall 

  

 10. 

 
keep a register with respect to each Series of Securities and to their transfer and exchange. The Company will give prompt written notice to the Trustee of
the name and address, and any change in the name or address, of each Registrar, Paying Agent or Service Agent. If at any time the Company shall fail to maintain any such required Registrar, Paying Agent or Service Agent or shall fail to furnish the
Trustee with the name and address thereof, such presentations, surrenders, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as its agent to receive all such
presentations, surrenders, notices and demands. 
  
 The Company
may also from time to time designate one or more co-registrars, additional paying agents or additional service agents and may from time to time rescind such designations; provided, however, that no such designation or rescission shall in any manner
relieve the Company of its obligations to maintain a Registrar, Paying Agent and Service Agent in each place so specified pursuant to Section 2.2 for Securities of any Series for such purposes. The Company will give prompt written notice to the
Trustee of any such designation or rescission and of any change in the name or address of any such co-registrar, additional paying agent or additional service agent. The term “Registrar” includes any co-registrar; the term “Paying
Agent” includes any additional paying agent; and the term “Service Agent” includes any additional service agent. 
  
 The Company hereby appoints the Trustee the initial Registrar, Paying Agent and Service Agent for each Series unless another Registrar, Paying Agent or
Service Agent, as the case may be, is appointed prior to the time Securities of that Series are first issued. 
  

	Section 	2.5 Paying Agent to Hold Money in Trust. 

  
 The Company shall require each Paying Agent other than the Trustee to agree in writing that the Paying Agent will hold in trust, for the benefit of
Securityholders of any Series of Securities, or the Trustee, all money held by the Paying Agent for the payment of principal of or interest on the Series of Securities, and will notify the Trustee of any default by the Company in making any such
payment. While any such default continues, the Trustee may require a Paying Agent to pay all money held by it to the Trustee. The Company at any time may require a Paying Agent to pay all money held by it to the Trustee. Upon payment over to the
Trustee, the Paying Agent (if other than the Company or a Subsidiary) shall have no further liability for the money. If the Company or a Subsidiary acts as Paying Agent, it shall segregate and hold in a separate trust fund for the benefit of
Securityholders of any Series of Securities all money held by it as Paying Agent. 
  

	Section 	2.6 Securityholder Lists. 

  
 The Trustee shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of
Securityholders of each Series of Securities and shall otherwise comply with TIA Section 312(a). If the Trustee is not the Registrar, the Company shall furnish to the Trustee at least ten days before each interest payment date and at such other
times as the Trustee may request in writing a list, in such form and as of such date as the Trustee may reasonably require, of the names and addresses of Securityholders of each Series of Securities. 
  

 11. 

	Section 	2.7 Transfer and Exchange. 

  
 Where Securities of a Series are presented to the Registrar or a co-registrar with a request to register a transfer or to exchange them for an equal
principal amount of Securities of the same Series, the Registrar shall register the transfer or make the exchange if its requirements for such transactions are met. To permit registrations of transfers and exchanges, the Trustee shall authenticate
Securities at the Registrar’s request. No service charge shall be made for any registration of transfer or exchange (except as otherwise expressly permitted herein), but the Company may require payment of a sum sufficient to cover any transfer
tax or similar governmental charge payable in connection therewith (other than any such transfer tax or similar governmental charge payable upon exchanges pursuant to Sections 2.11, 3.6 or 9.6). 
  
 Neither the Company nor the Registrar shall be required (a) to issue,
register the transfer of, or exchange Securities of any Series for the period beginning at the opening of business fifteen days immediately preceding the mailing of a notice of redemption of Securities of that Series selected for redemption and
ending at the close of business on the day of such mailing, or (b) to register the transfer of or exchange Securities of any Series selected, called or being called for redemption as a whole or the portion being redeemed of any such Securities
selected, called or being called for redemption in part. 
  

	Section 	2.8 Mutilated, Destroyed, Lost and Stolen Securities. 

  
 If any mutilated Security is surrendered to the Trustee, the Company shall execute and the Trustee shall authenticate and deliver in exchange therefor a
new Security of the same Series and of like tenor and principal amount and bearing a number not contemporaneously outstanding. 
  
 If there shall be delivered to the Company and the Trustee (i) evidence to their satisfaction of the destruction, loss or theft of any Security and (ii)
such security or indemnity as may be required by them to save each of them and any agent of either of them harmless, then, in the absence of notice to the Company or the Trustee that such Security has been acquired by a bona fide purchaser, the
Company shall execute and upon its request the Trustee shall authenticate and make available for delivery, in lieu of any such destroyed, lost or stolen Security, a new Security of the same Series and of like tenor and principal amount and bearing a
number not contemporaneously outstanding. 
  
 In case any such
mutilated, destroyed, lost or stolen Security has become or is about to become due and payable, the Company in its discretion may, instead of issuing a new Security, pay such Security. 
  
 Upon the issuance of any new Security under this Section, the Company may require the payment of a sum sufficient to cover
any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith. 
  
 Every new Security of any Series issued pursuant to this Section in lieu of any destroyed, lost or stolen Security shall
constitute an original additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable 

  

 12. 

 
by anyone, and shall be entitled to all the benefits of this Indenture equally and proportionately with any and all other Securities of that Series duly
issued hereunder. 
  
 The provisions of this Section are exclusive
and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities. 
  

	Section 	2.9 Outstanding Securities. 

  
 The Securities outstanding at any time are all the Securities authenticated by the Trustee except for those canceled by it, those delivered to it for
cancellation, those reductions in the interest on a Global Security effected by the Trustee in accordance with the provisions hereof and those described in this Section as not outstanding. 
  
 If a Security is replaced pursuant to Section 2.8, it ceases to be
outstanding until the Trustee receives proof satisfactory to it that the replaced Security is held by a bona fide purchaser. 
  
 If the Paying Agent (other than the Company, a Subsidiary or an Affiliate of any thereof) holds on the Maturity of Securities of a Series money sufficient
to pay such Securities payable on that date, then on and after that date such Securities of the Series cease to be outstanding and interest on them ceases to accrue. 
  
 A Security does not cease to be outstanding because the Company or an Affiliate holds the Security. 
  
 In determining whether the Holders of the requisite principal amount of
outstanding Securities have given any request, demand, authorization, direction, notice, consent or waiver hereunder, the principal amount of a Discount Security that shall be deemed to be outstanding for such purposes shall be the amount of the
principal thereof that would be due and payable as of the date of such determination upon a declaration of acceleration of the Maturity thereof pursuant to Section 6.2. 
  

	Section 	2.10 Treasury Securities. 

  
 In determining whether the Holders of the required principal amount of Securities of a Series have concurred in any request, demand, authorization,
direction, notice, consent or waiver Securities of a Series owned by the Company or an Affiliate shall be disregarded, except that for the purposes of determining whether the Trustee shall be protected in relying on any such request, demand,
authorization, direction, notice, consent or waiver only Securities of a Series that the Trustee knows are so owned shall be so disregarded. 
  

	Section 	2.11 Temporary Securities. 

  
 Until definitive Securities are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary Securities upon a Company Order.
Temporary Securities shall be substantially in the form of definitive Securities but may have variations that the Company considers appropriate for temporary Securities. Without unreasonable delay, the 

  

 13. 

 
Company shall prepare and the Trustee upon request shall authenticate definitive Securities of the same Series and date of maturity in exchange for temporary
Securities. Until so exchanged, temporary securities shall have the same rights under this Indenture as the definitive Securities. 
  

	Section 	2.12 Cancellation. 

  
 The Company at any time may deliver Securities to the Trustee for cancellation. The Registrar and the Paying Agent shall forward to the Trustee any
Securities surrendered to them for registration of transfer, exchange or payment. The Trustee shall cancel all Securities surrendered for transfer, exchange, payment, replacement or cancellation and shall destroy such canceled Securities (subject to
the record retention requirement of the Exchange Act) and deliver a certificate of such destruction to the Company, unless the Company otherwise directs. The Company may not issue new Securities to replace Securities that it has paid or delivered to
the Trustee for cancellation. 
  

	Section 	2.13 Defaulted Interest. 

  
 If the Company defaults in a payment of interest on a Series of Securities, it shall pay the defaulted interest, plus, to the extent permitted by law, any
interest payable on the defaulted interest, to the persons who are Securityholders of the Series on a subsequent special record date. The Company shall fix the record date and payment date. At least 30 days before the record date, the Company shall
mail to the Trustee and to each Securityholder of the Series a notice that states the record date, the payment date and the amount of interest to be paid. The Company may pay defaulted interest in any other lawful manner. 
  

	Section 	2.14 Global Securities. 

  
 2.14.1 Terms of Securities. A Board Resolution, a supplemental indenture hereto or an Officers’ Certificate shall
establish whether the Securities of a Series shall be issued in whole or in part in the form of one or more Global Securities and the Depository for such Global Security or Securities. 
  
 2.14.2 Transfer and Exchange. Notwithstanding any provisions to the contrary contained in
Section 2.7 of the Indenture and in addition thereto, any Global Security shall be exchangeable pursuant to Section 2.7 of the Indenture for Securities registered in the names of Holders other than the Depository for such Security or its nominee
only if (i) such Depository notifies the Company that it is unwilling or unable to continue as Depository for such Global Security or if at any time such Depository ceases to be a clearing agency registered under the Exchange Act, and, in either
case, the Company fails to appoint a successor Depository within 90 days of such event, (ii) the Company executes and delivers to the Trustee an Officers’ Certificate to the effect that such Global Security shall be so exchangeable or (iii) an
Event of Default with respect to the Securities represented by such Global Security shall have happened and be continuing. Any Global Security that is exchangeable pursuant to the preceding sentence shall be exchangeable for Securities registered in
such names as the Depository shall direct in writing in an aggregate principal amount equal to the principal amount of the Global Security with like tenor and terms. 
  

 14. 

 Except as provided in this Section 2.14.2, a Global Security may not be transferred except as a whole by
the Depository with respect to such Global Security to a nominee of such Depository, by a nominee of such Depository to such Depository or another nominee of such Depository or by the Depository or any such nominee to a successor Depository or a
nominee of such a successor Depository. 
  
 2.14.3 Legend. Unless otherwise provided pursuant to Section 2.2, any Global Security issued hereunder shall bear a legend in substantially the following form: 
  
 “This Security is a Global Security within the meaning of the Indenture hereinafter referred to and is
registered in the name of the Depository or a nominee of the Depository. This Security is exchangeable for Securities registered in the name of a person other than the Depository or its nominee only in the limited circumstances described in the
Indenture, and may not be transferred except as a whole by the Depository to a nominee of the Depository, by a nominee of the Depository to the Depository or another nominee of the Depository or by the Depository or any such nominee to a successor
Depository or a nominee of such a successor Depository.” 
  
 2.14.4 Acts of Holders. The Depository, as a Holder, may appoint agents and otherwise authorize participants to give or take any request, demand, authorization, direction, notice, consent, waiver or
other action which a Holder is entitled to give or take under the Indenture. 
  
 2.14.5 Payments. Notwithstanding the other provisions of this Indenture, unless otherwise specified as contemplated by Section 2.2, payment of the principal of, premium, if any, and interest, if any, on
any Global Security shall be made to the Holder thereof. 
  
 2.14.6 Consents, Declaration and Directions. Except as provided in Section 2.14.5, the Company, the Trustee and any Agent shall treat a person as the Holder of such principal amount of outstanding
Securities of such Series represented by a Global Security as shall be specified in a written statement of the Depositary with respect to such Global Security, for purposes of obtaining any consents, declarations, waivers or directions required to
be given by the Holders pursuant to this Indenture. 
  

	Section 	2.15 CUSIP Numbers. 

  
 The Company in issuing the Securities may use “CUSIP” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP”
numbers in notices of redemption as a convenience to Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a
redemption and that reliance may be placed only on the other elements of identification printed on the Securities, and any such redemption shall not be affected by any defect in or omission of such numbers. 
  

 15. 

 ARTICLE III 
  
 REDEMPTION 
  

	Section 	3.1 Notice to Trustee. 

  
 The Company may, with respect to any Series of Securities, reserve the right to redeem and pay the Series of Securities or may covenant to redeem and pay
the Series of Securities or any part thereof prior to the Stated Maturity thereof at such time and on such terms as provided for in such Securities. If a Series of Securities is redeemable and the Company wants or is obligated to redeem prior to the
Stated Maturity thereof all or part of the Series of Securities pursuant to the terms of such Securities, it shall notify the Trustee of the redemption date and the principal amount of Series of Securities to be redeemed. The Company shall give the
notice at least 45 days before the redemption date (or such shorter notice as may be acceptable to the Trustee). 
  

	Section 	3.2 Selection of Securities to be Redeemed. 

  
 Unless otherwise indicated for a particular Series by a Board Resolution, a supplemental indenture or an Officers’ Certificate, if less than all the
Securities of a Series are to be redeemed, the Trustee shall select the Securities of the Series to be redeemed in any manner that the Trustee deems fair and appropriate. The Trustee shall make the selection from Securities of the Series outstanding
not previously called for redemption. The Trustee may select for redemption portions of the principal of Securities of the Series that have denominations larger than $1,000. Securities of the Series and portions of them it selects shall be in
amounts of $1,000 or whole multiples of $1,000 or, with respect to Securities of any Series issuable in other denominations pursuant to Section 2.2.10, the minimum principal denomination for each Series and integral multiples thereof. Provisions of
this Indenture that apply to Securities of a Series called for redemption also apply to portions of Securities of that Series called for redemption. 
  

	Section 	3.3 Notice of Redemption. 

  
 Unless otherwise indicated for a particular Series by Board Resolution, a supplemental indenture hereto or an Officers’ Certificate, at least 30 days
but not more than 90 days before a redemption date, the Company shall mail a notice of redemption by first-class mail to each Holder whose Securities are to be redeemed and if any Bearer Securities are outstanding, publish on one occasion a notice
in an Authorized Newspaper. 
  
 The notice shall identify the
Securities of the Series to be redeemed and shall state: 
  
 (a) the redemption date; 
  
 (b) the redemption price; 
  
 (c) the name and address of the Paying Agent; 
  
 (d) that Securities of the Series called for redemption must be surrendered to the Paying Agent to collect the redemption price;

  

 16. 

 (e) that interest on Securities of the Series called for redemption ceases to
accrue on and after the redemption date; and 
  
 (f) any other information as may be required by the terms of the particular Series or the Securities of a Series being redeemed. 
  
 At the Company’s request, the Trustee shall give the notice of redemption in the Company’s name and at its expense. 
  

	Section 	3.4 Effect of Notice of Redemption. 

  
 Once notice of redemption is mailed or published as provided in Section 3.3, Securities of a Series called for redemption become due and payable on the
redemption date and at the redemption price. A notice of redemption may not be conditional. Upon surrender to the Paying Agent, such Securities shall be paid at the redemption price plus accrued interest to the redemption date. 
  

	Section 	3.5 Deposit of Redemption Price. 

  
 On or before the redemption date, the Company shall deposit with the Paying Agent money sufficient to pay the redemption price of and accrued interest, if
any, on all Securities to be redeemed on that date. 
  

	Section 	3.6 Securities Redeemed in Part. 

  
 Upon surrender of a Security that is redeemed in part, the Trustee shall authenticate for the Holder a new Security of the same Series and the same
maturity equal in principal amount to the unredeemed portion of the Security surrendered. 
  
 ARTICLE IV 
  
 COVENANTS

  

	Section 	4.1 Payment of Principal and Interest. 

  
 The Company covenants and agrees for the benefit of the Holders of each Series of Securities that it will duly and punctually pay the principal of and
interest, if any, on the Securities of that Series in accordance with the terms of such Securities and this Indenture. 
  

	Section 	4.2 SEC Reports. 

  
 The Company shall deliver to the Trustee after it files them with the SEC copies of the annual reports and of the information, documents, and other
reports (or copies of such portions of any of the foregoing as the SEC may by rules and regulations prescribe) which the Company is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act. The Company also shall comply with
the other provisions of TIA Section 314(a). 
  

 17. 

	Section 	4.3 Compliance Certificate. 

  
 The Company shall deliver to the Trustee, within 120 days after the end of each fiscal year of the Company, an Officers’ Certificate stating that a
review of the activities of the Company and its Subsidiaries during the preceding fiscal year has been made under the supervision of the signing Officers with a view to determining whether the Company has kept, observed, performed and fulfilled its
obligations under this Indenture, and further stating, as to each such Officer signing such certificate, that to the best of his knowledge the Company has kept, observed, performed and fulfilled each and every covenant contained in this Indenture
and is not in default in the performance or observance of any of the terms, provisions and conditions hereof (or, if a Default or Event of Default shall have occurred, describing all such Defaults or Events of Default of which he may have
knowledge). 
  
 The Company will, so long as any of the Securities
are outstanding, deliver to the Trustee, forthwith upon becoming aware of any Default or Event of Default, an Officers’ Certificate specifying such Default or Event of Default and what action the Company is taking or proposes to take with
respect thereto. 
  

	Section 	4.4 Corporate Existence. 

  
 Subject to Article V, the Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate existence
and the rights (charter and statutory), licenses and franchises of the Company; provided, however, that the Company shall not be required to preserve any such right, license or franchise, if the Board of Directors shall determine that the
preservation thereof is no longer desirable in the conduct of the business of the Company and its Subsidiaries taken as a whole and that the loss thereof is not adverse in any material respect to the Holders. 
  

	Section 	4.5 Taxes. 

  
 The Company shall pay prior to delinquency all taxes, assessments and governmental levies, except as contested in good faith and by appropriate
proceedings. 
  
 ARTICLE V 
  
 SUCCESSORS 
  

	Section 	5.1 When Company May Merge, Etc. 

  
 The Company shall not consolidate with or merge into, or convey, transfer or lease all or substantially all of its properties and assets to, any person (a
“successor person”), and may not permit any person to merge into, or convey, transfer or lease its properties and assets substantially as an entirety to, the Company, unless: 
  
 (a) the successor person (if any) is a corporation, partnership, trust or other entity organized and
validly existing under the laws of any U.S. domestic jurisdiction and expressly assumes the Company’s obligations on the Securities and under this Indenture and 
  

 18. 

 (b) immediately after giving effect to the transaction, no Default or Event of
Default, shall have occurred and be continuing. 
  
 The Company
shall deliver to the Trustee prior to the consummation of the proposed transaction an Officers’ Certificate to the foregoing effect and an Opinion of Counsel stating that the proposed transaction and such supplemental indenture comply with this
Indenture. 
  

	Section 	5.2 Successor Corporation Substituted. 

  
 Upon any consolidation or merger, or any sale, lease, conveyance or other disposition of all or substantially all of the assets of the Company in
accordance with Section 5.1, the successor corporation formed by such consolidation or into or with which the Company is merged or to which such sale, lease, conveyance or other disposition is made shall succeed to, and be substituted for, and may
exercise every right and power of, the Company under this Indenture with the same effect as if such successor person has been named as the Company herein; provided, however, that the predecessor Company in the case of a sale, lease, conveyance or
other disposition shall not be released from the obligation to pay the principal of and interest, if any, on the Securities. 
  
 ARTICLE VI 
  
 DEFAULTS AND REMEDIES 
  

	Section 	6.1 Events of Default. 

  
 “Event of Default,” wherever used herein with respect to Securities of any Series, means any one of the following events, unless in the
establishing Board Resolution, supplemental indenture or Officers’ Certificate, it is provided that such Series shall not have the benefit of said Event of Default: 
  
 (a) default in the payment of any interest on any Security of that Series when it becomes due and
payable, and continuance of such default for a period of 90 days (unless the entire amount of such payment is deposited by the Company with the Trustee or with a Paying Agent prior to the expiration of such period of 90 days); or 
  
 (b) default in the payment of the principal of any
Security of that Series at its Maturity; or 
  
 (c) default in the deposit of any sinking fund payment, when and as due in respect of any Security of that Series; or 
  
 (d) default in the performance or breach of any covenant or warranty of the Company in this Indenture (other than a covenant or
warranty that has been included in this Indenture solely for the benefit of Series of Securities other than that Series), which default continues uncured for a period of 90 days after there has been given, by registered or certified mail, to the
Company by the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal amount of the outstanding Securities of that Series a written notice 

  

 19. 

 
specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; or 

 
 (e) the Company pursuant to or within the meaning
of any Bankruptcy Law: 
  
 (i) commences a
voluntary case, 
  
 (ii) consents to the
entry of an order for relief against it in an involuntary case, 
  
 (iii) consents to the appointment of a Custodian of it or for all or substantially all of its property, 
  
 (iv) makes a general assignment for the benefit of its creditors, or 
  
 (v) generally is unable to pay its debts as the same become due; or 
  
 (f) a court of competent jurisdiction enters an order
or decree under any Bankruptcy Law that: 
  
 (i) is for relief against the Company in an involuntary case, 
  
 (ii) appoints a Custodian for the Company or for all or substantially all of its property, or 
  
 (iii) orders the liquidation of the Company and the order or decree remains unstayed and in effect for 90 days; or 
  
 (g) any other Event of Default provided with respect
to Securities of that Series, which is specified in a Board Resolution, a supplemental indenture hereto or an Officers’ Certificate, in accordance with Section 2.2.19. 
  
 The term “Bankruptcy Law” means title 11, U.S. Code or any similar Federal or State law for the relief of debtors.
The term “Custodian” means any receiver, trustee, assignee, liquidator or similar official under any Bankruptcy Law. 
  

	Section 	6.2 Acceleration of Maturity; Rescission and Annulment. 

  
 If an Event of Default with respect to Securities of any Series at the time outstanding occurs and is continuing (other than an Event of Default referred
to in Section 6.1(e) or (f)) then in every such case the Trustee or the Holders of not less than 25% in principal amount of the outstanding Securities of that Series may declare the principal amount (or, if any Securities of that Series are Discount
Securities, such portion of the principal amount as may be specified in the terms of such Securities) of and accrued and unpaid interest, if any, on all of the Securities of that Series to be due and payable immediately, by a notice in writing to
the Company (and to the Trustee if given by Holders), and upon any such declaration such principal amount (or specified amount) and accrued and unpaid interest, if any, shall become immediately due and payable. If an Event of Default specified in
Section 6.1(e) or (f) shall occur, the principal amount (or 

  

 20. 

 
specified amount) of and accrued and unpaid interest, if any, on all outstanding Securities shall ipso facto become and be immediately due and payable
without any declaration or other act on the part of the Trustee or any Holder. 
  
 At any time after such a declaration of acceleration with respect to any Series has been made and before a judgment or decree for payment of the money due has been obtained by the Trustee as hereinafter in this
Article provided, the Holders of a majority in principal amount of the outstanding Securities of that Series, by written notice to the Company and the Trustee, may rescind and annul such declaration and its consequences if: 
  
 (a) the Company has paid or deposited with the
Trustee a sum sufficient to pay 
  
 (i)
all overdue interest, if any, on all Securities of that Series, 
  
 (ii) the principal of any Securities of that Series which have become due otherwise than by such declaration of acceleration and interest thereon at the rate or rates prescribed therefor in such Securities,

  
 (iii) to the extent that payment of
such interest is lawful, interest upon any overdue principal and overdue interest at the rate or rates prescribed therefor in such Securities, and 
  
 (iv) all sums paid or advanced by the Trustee hereunder and the reasonable compensation, expenses, disbursements and advances of
the Trustee, its agents and counsel; and 
  
 (b) all Events of Default with respect to Securities of that Series, other than the non-payment of the principal of Securities of that Series which have become due solely by such declaration of acceleration, have been cured or waived
as provided in Section 6.13. 
  
 No such rescission shall affect
any subsequent Default or impair any right consequent thereon. 
  

	Section 	6.3 Collection of Indebtedness and Suits for Enforcement by Trustee. 

  

The Company covenants that if 
  
 (a) default is made in the payment of any interest on any Security when such interest becomes due and payable and such default
continues for a period of 90 days, or 
  
 (b)
default is made in the payment of principal of any Security at the Maturity thereof, or 
  
 (c) default is made in the deposit of any sinking fund payment when and as due by the terms of a Security, then, the Company will,
upon demand of the Trustee, pay to it, for the benefit of the Holders of such Securities, the whole amount then due and payable on such Securities for principal and interest and, to the extent that payment of such interest shall be 

  

 21. 

 
legally enforceable, interest on any overdue principal or any overdue interest, at the rate or rates prescribed therefor in such Securities, and, in addition
thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 
  
 If the Company fails to pay such amounts forthwith upon such demand, the
Trustee, in its own name and as trustee of an express trust, may institute a judicial proceeding for the collection of the sums so due and unpaid, may prosecute such proceeding to judgment or final decree and may enforce the same against the Company
or any other obligor upon such Securities and collect the moneys adjudged or deemed to be payable in the manner provided by law out of the property of the Company or any other obligor upon such Securities, wherever situated. 
  
 If an Event of Default with respect to any Securities of any Series occurs
and is continuing, the Trustee may in its discretion proceed to protect and enforce its rights and the rights of the Holders of Securities of such Series by such appropriate judicial proceedings as the Trustee shall deem most effectual to protect
and enforce any such rights, whether for the specific enforcement of any covenant or agreement in this Indenture or in aid of the exercise of any power granted herein, or to enforce any other proper remedy. 
  

	Section 	6.4 Trustee May File Proofs of Claim. 

  
 In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial
proceeding relative to the Company or any other obligor upon the Securities or the property of the Company or of such other obligor or their creditors, the Trustee (irrespective of whether the principal of the Securities shall then be due and
payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand on the Company for the payment of overdue principal or interest) shall be entitled and empowered, by intervention in such
proceeding or otherwise, 
  
 (a) to file
and prove a claim for the whole amount of principal and interest owing and unpaid in respect of the Securities and to file such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any
claim for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and of the Holders allowed in such judicial proceeding, and 
  
 (b) to collect and receive any moneys or other property payable or deliverable on any such claims and
to distribute the same, and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event
that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any amount due it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any
other amounts due the Trustee under Section 7.7. 
  
 Nothing
herein contained shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of reorganization, arrangement, 

  

 22. 

 
adjustment or composition affecting the Securities or the rights of any Holder thereof or to authorize the Trustee to vote in respect of the claim of any
Holder in any such proceeding. 
  

	Section 	6.5 Trustee May Enforce Claims Without Possession of Securities. 

  
 All rights of action and claims under this Indenture or the Securities may be prosecuted and enforced by the Trustee without the possession of any of the
Securities or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for the
payment of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable benefit of the Holders of the Securities in respect of which such judgment has been recovered. 
  

	Section 	6.6 Application of Money Collected. 

  
 Any money collected by the Trustee pursuant to this Article shall be applied in the following order, at the date or dates fixed by the Trustee and, in
case of the distribution of such money on account of principal or interest, upon presentation of the Securities and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid: 
  
 First: To the payment of all amounts due the Trustee under Section 7.7; and

  
 Second: To the payment of the amounts then due and unpaid for
principal of and interest on the Securities in respect of which or for the benefit of which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on such Securities for principal
and interest, respectively; and 
  
 Third: To the Company.

  

	Section 	6.7 Limitation on Suits. 

  
 No Holder of any Security of any Series shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, or for
the appointment of a receiver or trustee, or for any other remedy hereunder, unless 
  
 (a) such Holder has previously given written notice to the Trustee of a continuing Event of Default with respect to the Securities
of that Series; 
  
 (b) the Holders of not
less than 25% in principal amount of the outstanding Securities of that Series shall have made written request to the Trustee to institute proceedings in respect of such Event of Default in its own name as Trustee hereunder; 
  
 (c) such Holder or Holders have offered to the
Trustee reasonable indemnity against the costs, expenses and liabilities to be incurred in compliance with such request; 
  
 (d) the Trustee for 90 days after its receipt of such notice, request and offer of indemnity has failed to institute any such
proceeding; and 
  

 23. 

 (e) no direction inconsistent with such written request has been given to the
Trustee during such 90-day period by the Holders of a majority in principal amount of the outstanding Securities of that Series; 
  
 it being understood and intended that no one or more of such Holders shall have any right in any manner whatever by virtue of, or by availing of, any provision of this
Indenture to affect, disturb or prejudice the rights of any other of such Holders, or to obtain or to seek to obtain priority or preference over any other of such Holders or to enforce any right under this Indenture, except in the manner herein
provided and for the equal and ratable benefit of all such Holders. 
  

	Section 	6.8 Unconditional Right of Holders to Receive Principal and Interest. 

  

Notwithstanding any other provision in this Indenture, the Holder of any Security shall have the right, which is absolute and unconditional, to receive
payment of the principal of and interest, if any, on such Security on the Stated Maturity or Stated Maturities expressed in such Security (or, in the case of redemption, on the redemption date) and to institute suit for the enforcement of any such
payment, and such rights shall not be impaired without the consent of such Holder. 
  

	Section 	6.9 Restoration of Rights and Remedies. 

  
 If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been discontinued
or abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case, subject to any determination in such proceeding, the Company, the Trustee and the Holders shall be restored severally and
respectively to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding had been instituted. 
  

	Section 	6.10 Rights and Remedies Cumulative. 

  
 Except as otherwise provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities in Section 2.8, no right or
remedy herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right
and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate
right or remedy. 
  

	Section 	6.11 Delay or Omission Not Waiver. 

  
 No delay or omission of the Trustee or of any Holder of any Securities to exercise any right or remedy accruing upon any Event of Default shall impair any
such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy given by this Article or by law to the Trustee or to the Holders may be exercised from time to time, and as often as may be
deemed expedient, by the Trustee or by the Holders, as the case may be. 
  

 24. 

	Section 	6.12 Control by Holders. 

  
 The Holders of a majority in principal amount of the outstanding Securities of any Series shall have the right to direct the time, method and place of
conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee, with respect to the Securities of such Series, provided that 
  
 (a) such direction shall not be in conflict with any rule of law or with this Indenture, 

 
 (b) the Trustee may take any other action deemed
proper by the Trustee which is not inconsistent with such direction, and 
  
 (c) subject to the provisions of Section 6.1, the Trustee shall have the right to decline to follow any such direction if the Trustee in good faith shall, by a Responsible Officer of the Trustee, determine that
the proceeding so directed would involve the Trustee in personal liability. 
  

	Section 	6.13 Waiver of Past Defaults. 

  
 Subject to Section 6.2, the Holders of not less than a majority in principal amount of the outstanding Securities of any Series may on behalf of the
Holders of all the Securities of such Series waive any past Default hereunder with respect to such Series and its consequences, except a Default in the payment of the principal of or interest on any Security of such Series (provided, however, that
the Holders of a majority in principal amount of the outstanding Securities of any Series may rescind an acceleration and its consequences, including any related payment default that resulted from such acceleration). Upon any such waiver, such
Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured, for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other Default or impair any right consequent
thereon. 
  

	Section 	6.14 Undertaking for Costs. 

  
 All parties to this Indenture agree, and each Holder of any Security by his acceptance thereof shall be deemed to have agreed, that any court may in its
discretion require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, the filing by any party litigant in such suit of an
undertaking to pay the costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the merits and good faith of the
claims or defenses made by such party litigant; but the provisions of this Section shall not apply to any suit instituted by the Company, to any suit instituted by the Trustee, to any suit instituted by any Holder, or group of Holders, holding in
the aggregate more than 10% in principal amount of the outstanding Securities of any Series, or to any suit instituted by any Holder for the enforcement of the payment of the principal of or interest on any Security on or after the Stated Maturity
or Stated Maturities expressed in such Security (or, in the case of redemption, on the redemption date). 
  

 25. 

 ARTICLE VII 
  
 TRUSTEE 
  

	Section 	7.1 Duties of Trustee. 

  
 (a) If an Event of Default has occurred and is continuing, the Trustee shall exercise the rights and powers vested in it by this
Indenture and use the same degree of care and skill in their exercise as a prudent man would exercise or use under the circumstances in the conduct of his own affairs. 
  
 (b) Except during the continuance of an Event of Default: 
  
 (i) The Trustee need perform only those duties that
are specifically set forth in this Indenture and no others. 
  
 (ii) In the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon Officers’ Certificates or
Opinions of Counsel furnished to the Trustee and conforming to the requirements of this Indenture; however, in the case of any such Officers’ Certificates or Opinions of Counsel which by any provisions hereof are specifically required to be
furnished to the Trustee, the Trustee shall examine such Officers’ Certificates and Opinions of Counsel to determine whether or not they conform to the requirements of this Indenture. 
  
 (c) The Trustee may not be relieved from liability
for its own negligent action, its own negligent failure to act or its own willful misconduct, except that: 
  
 (i) This paragraph does not limit the effect of paragraph (b) of this Section. 
  
 (ii) The Trustee shall not be liable for any error of
judgment made in good faith by a Responsible Officer, unless it is proved that the Trustee was negligent in ascertaining the pertinent facts. 
  
 (iii) The Trustee shall not be liable with respect to any action taken, suffered or omitted to be taken by it with respect to
Securities of any Series in good faith in accordance with the direction of the Holders of a majority in principal amount of the outstanding Securities of such Series relating to the time, method and place of conducting any proceeding for any remedy
available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture with respect to the Securities of such Series. 
  
 (d) Every provision of this Indenture that in any way relates to the Trustee is subject to paragraph (a), (b) and (c) of this
Section. 
  
 (e) The Trustee may refuse to
perform any duty or exercise any right or power unless it receives indemnity satisfactory to it against any loss, liability or expense. 
  

 26. 

 (f) The Trustee shall not be liable for interest on any money received by it
except as the Trustee may agree in writing with the Company. Money held in trust by the Trustee need not be segregated from other funds except to the extent required by law. 
  
 (g) No provision of this Indenture shall require the Trustee to risk its own funds or otherwise incur
any financial liability in the performance of any of its duties, or in the exercise of any of its rights or powers, if it shall have reasonable grounds for believing that repayment of such funds or adequate indemnity against such risk is not
reasonably assured to it. 
  
 (h) The
Paying Agent, the Registrar and any authenticating agent shall be entitled to the protections and immunities as are set forth in paragraphs (a), (b) and (c) of this Section with respect to the Trustee. 
  

	Section 	7.2 Rights of Trustee. 

  
 (a) The Trustee may rely on and shall be protected in acting or refraining from acting upon any document believed by it to be
genuine and to have been signed or presented by the proper person. The Trustee need not investigate any fact or matter stated in the document. 
  
 (b) Before the Trustee acts or refrains from acting, it may require an Officers’ Certificate or an Opinion of Counsel. The
Trustee shall not be liable for any action it takes or omits to take in good faith in reliance on such Officers’ Certificate or Opinion of Counsel. 
  
 (c) The Trustee may act through agents and shall not be responsible for the misconduct or negligence of any agent appointed with
due care. No Depository shall be deemed an agent of the Trustee and the Trustee shall not be responsible for any act or omission by any Depository. 
  
 (d) The Trustee shall not be liable for any action it takes or omits to take in good faith which it believes to be authorized or
within its rights or powers. 
  
 (e) The
Trustee may consult with counsel and the advice of such counsel or any Opinion of Counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in reliance
thereon. 
  
 (f) The Trustee shall be
under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or direction of any of the Holders of Securities unless such Holders shall have offered to the Trustee reasonable security or indemnity against
the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction. 
  
 In addition, the Trustee shall not be deemed to have knowledge of any Default or Event of Default except (1) any Event of Default occurring pursuant to
Sections 6.1(a)(1), 6.1(a)(2), 6.1(a)(3) and 4.1 hereof or (2) any Default or Event of Default of which the Trustee shall have received written notification in the manner set forth in this Indenture or a Responsible Officer of the Trustee shall have
obtained actual knowledge. Delivery of reports, information and documents to the Trustee under Section 4.2 is for informational purposes only and the 

  

 27. 

 
information and the Trustee’s receipt of the foregoing shall not constitute constructive notice of any information contained therein, or determinable
from information contained therein including the Company’s compliance with any of their covenants thereunder (as to which the Trustee is entitled to rely exclusively on an Officers’ Certificate). 
  

	Section 	7.3 Individual Rights of Trustee. 

  
 The Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or an Affiliate
with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights. The Trustee is also subject to Sections 7.10 and 7.11. 
  

	Section 	7.4 Trustee’s Disclaimer. 

  
 The Trustee makes no representation as to the validity or adequacy of this Indenture or the Securities, it shall not be accountable for the Company’s
use of the proceeds from the Securities, and it shall not be responsible for any statement in the Securities other than its authentication. 
  

	Section 	7.5 Notice of Defaults. 

  
 If a Default or Event of Default occurs and is continuing with respect to the Securities of any Series and if it is known to a Responsible Officer of the
Trustee, the Trustee shall mail to each Securityholder of the Securities of that Series and, if any Bearer Securities are outstanding, publish on one occasion in an Authorized Newspaper, notice of a Default or Event of Default within 90 days after
it occurs or, if later, after a Responsible Officer of the Trustee has knowledge of such Default or Event of Default. Except in the case of a Default or Event of Default in payment of principal of or interest on any Security of any Series, the
Trustee may withhold the notice if and so long as its corporate trust committee or a committee of its Responsible Officers in good faith determines that withholding the notice is in the interests of Securityholders of that Series. 
  

	Section 	7.6 Reports by Trustee to Holders. 

  
 Within 60 days after May 15 in each year, the Trustee shall transmit by mail to all Securityholders, as their names and addresses appear on the register
kept by the Registrar and, if any Bearer Securities are outstanding, publish in an Authorized Newspaper, a brief report dated as of such May 15, in accordance with, and to the extent required under, TIA Section 313. 
  
 A copy of each report at the time of its mailing to Securityholders of any
Series shall be filed with the SEC and each stock exchange on which the Securities of that Series are listed. The Company shall promptly notify the Trustee when Securities of any Series are listed on any stock exchange. 
  

	Section 	7.7 Compensation and Indemnity. 

  
 The Company shall pay to the Trustee from time to time reasonable compensation for its services. The Trustee’s compensation shall not be limited by
any law on compensation of a 

  

 28. 

 
trustee of an express trust. The Company shall reimburse the Trustee upon request for all reasonable out-of-pocket expenses incurred by it. Such expenses
shall include the reasonable compensation and expenses of the Trustee’s agents and counsel. 
  
 The Company shall indemnify the Trustee (including the cost of defending itself) against any loss, liability or expense incurred by it except as set forth
in the next paragraph in the performance of its duties under this Indenture as Trustee or Agent. The Trustee shall notify the Company promptly of any claim for which it may seek indemnity. The Company shall defend the claim and the Trustee shall
cooperate in the defense. The Trustee may have separate counsel and the Company shall pay the reasonable fees and expenses of such counsel. The Company need not pay for any settlement made without its consent, which consent shall not be unreasonably
withheld. This indemnification shall apply to officers, directors, employees, shareholders and agents of the Trustee. 
  
 The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee or by any officer, director, employee,
shareholder or agent of the Trustee through negligence or bad faith. 
  
 To secure the Company’s payment obligations in this Section, the Trustee shall have a lien prior to the Securities of any Series on all money or property held or collected by the Trustee, except that held in trust to pay principal and
interest on particular Securities of that Series. 
  
 When the
Trustee incurs expenses or renders services after an Event of Default specified in Section 6.1(e) or (f) occurs, the expenses and the compensation for the services are intended to constitute expenses of administration under any Bankruptcy Law.

  

	Section 	7.8 Replacement of Trustee. 

  
 A resignation or removal of the Trustee and appointment of a successor Trustee shall become effective only upon the successor Trustee’s acceptance of
appointment as provided in this Section. 
  
 The Trustee may
resign with respect to the Securities of one or more Series by so notifying the Company. The Holders of a majority in principal amount of the Securities of any Series may remove the Trustee with respect to that Series by so notifying the Trustee and
the Company. The Company may remove the Trustee with respect to Securities of one or more Series if: 
  
 (a) the Trustee fails to comply with Section 7.10; 
  
 (b) the Trustee is adjudged a bankrupt or an insolvent or an order for relief is entered with respect
to the Trustee under any Bankruptcy Law; 
  
 (c) a Custodian or public officer takes charge of the Trustee or its property; or 
  
 (d) the Trustee becomes incapable of acting. 
  

 29. 

 If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the
Company shall promptly appoint a successor Trustee. Within one year after the successor Trustee takes office, the Holders of a majority in principal amount of the then outstanding Securities may appoint a successor Trustee to replace the successor
Trustee appointed by the Company. 
  
 If a successor Trustee with
respect to the Securities of any one or more Series does not take office within 30 days after the retiring Trustee resigns or is removed, the retiring Trustee, the Company or the Holders of at least 10% in principal amount of the Securities of the
applicable Series may petition any court of competent jurisdiction for the appointment of a successor Trustee. 
  
 If the Trustee with respect to the Securities of any one or more Series fails to comply with Section 7.10, any Securityholder of the applicable Series may
petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 
  
 A successor Trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that, the retiring
Trustee shall transfer all property held by it as Trustee to the successor Trustee subject to the lien provided for in Section 7.7, the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all
the rights, powers and duties of the Trustee with respect to each Series of Securities for which it is acting as Trustee under this Indenture. A successor Trustee shall mail a notice of its succession to each Securityholder of each such Series and,
if any Bearer Securities are outstanding, publish such notice on one occasion in an Authorized Newspaper. Notwithstanding replacement of the Trustee pursuant to this Section 7.8, the Company’s obligations under Section 7.7 hereof shall continue
for the benefit of the retiring trustee with respect to expenses and liabilities incurred by it prior to such replacement. 
  

	Section 	7.9 Successor Trustee by Merger, etc. 

  
 If the Trustee consolidates with, merges or converts into, or transfers all or substantially all of its corporate trust business to, another corporation,
the successor corporation without any further act shall be the successor Trustee. 
  

	Section 	7.10 Eligibility; Disqualification. 

  
 This Indenture shall always have a Trustee who satisfies the requirements of TIA Section 310(a) (1), (2) and (5). The Trustee shall always have a combined
capital and surplus of at least $25,000,000 as set forth in its most recent published annual report of condition. The Trustee shall comply with TIA Section 310(b). 
  

	Section 	7.11 Preferential Collection of Claims Against Company. 

  
 The Trustee is subject to TIA Section 311(a), excluding any creditor relationship listed in TIA Section 311(b). A Trustee who has resigned or been removed
shall be subject to TIA Section 311(a) to the extent indicated. 
  

 30. 

 ARTICLE VIII 
  
 SATISFACTION AND DISCHARGE; DEFEASANCE 
  

	Section 	8.1 Satisfaction and Discharge of Indenture. 

  
 This Indenture shall upon Company Order cease to be of further effect (except as hereinafter provided in this Section 8.1), and the Trustee, at the
expense of the Company, shall execute proper instruments acknowledging satisfaction and discharge of this Indenture, when 
  
 (a) either 
  
 (i) all Securities theretofore authenticated and delivered (other than Securities that have been destroyed, lost or stolen and that
have been replaced or paid) have been delivered to the Trustee for cancellation; or 
  
 (ii) all such Securities not theretofore delivered to the Trustee for cancellation 
  
 (1) have become due and payable, or 
  
 (2) will become due and payable at their Stated
Maturity within one year, or 
  
 (3) are
to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company, or 
  
 (4) are deemed paid and discharged pursuant to
Section 8.3, as applicable; 
  
 and the Company, in the case of (1), (2) or (3)
above, has deposited or caused to be deposited with the Trustee as trust funds in trust an amount sufficient for the purpose of paying and discharging the entire indebtedness on such Securities not theretofore delivered to the Trustee for
cancellation, for principal and interest to the date of such deposit (in the case of Securities which have become due and payable on or prior to the date of such deposit) or to the Stated Maturity or redemption date, as the case may be; 

 
 (b) the Company has paid or caused to be paid all
other sums payable hereunder by the Company; and 
  
 (c) the Company has delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that all conditions precedent herein provided for relating to the satisfaction and discharge of this Indenture have
been complied with. 
  
 Notwithstanding the satisfaction and
discharge of this Indenture, the obligations of the Company to the Trustee under Section 7.7, and, if money shall have been deposited with the 

  

 31. 

 
Trustee pursuant to clause (a) of this Section, the provisions of Sections 2.4, 2.7, 2.8, 8.1 8.2 and 8.5 shall survive. 
  

	Section 	8.2 Application of Trust Funds; Indemnification. 

  
 (a) Subject to the provisions of Section 8.5, all money deposited with the Trustee pursuant to Section 8.1, all money and U.S.
Government Obligations or Foreign Government Obligations deposited with the Trustee pursuant to Section 8.3 or 8.4 and all money received by the Trustee in respect of U.S. Government Obligations or Foreign Government Obligations deposited with the
Trustee pursuant to Section 8.3 or 8.4, shall be held in trust and applied by it, in accordance with the provisions of the Securities and this Indenture, to the payment, either directly or through any Paying Agent (including the Company acting as
its own Paying Agent) as the Trustee may determine, to the persons entitled thereto, of the principal and interest for whose payment such money has been deposited with or received by the Trustee or to make mandatory sinking fund payments or
analogous payments as contemplated by Sections 8.3 or 8.4. 
  
 (b) The Company shall pay and shall indemnify the Trustee against any tax, fee or other charge imposed on or assessed against U.S. Government Obligations or Foreign Government Obligations deposited pursuant to
Sections 8.3 or 8.4 or the interest and principal received in respect of such obligations other than any payable by or on behalf of Holders. 
  
 (c) The Trustee shall deliver or pay to the Company from time to time upon Company Request any U.S. Government Obligations or
Foreign Government Obligations or money held by it as provided in Sections 8.3 or 8.4 which are then in excess of the amount thereof which then would have been required to be deposited for the purpose for which such U.S. Government Obligations or
Foreign Government Obligations or money were deposited or received. This provision shall not authorize the sale by the Trustee of any U.S. Government Obligations or Foreign Government Obligations held under this Indenture. 
  

	Section 	8.3 Legal Defeasance of Securities of any Series. 

  
 Unless this Section 8.3 is otherwise specified, pursuant to Section 2.2.21, to be inapplicable to Securities of any Series, the Company shall be deemed to
have paid and discharged the entire indebtedness on all the outstanding Securities of such Series on the 91st day after the date of the deposit referred to in subparagraph (d) hereof, and the provisions of this Indenture, as it relates to such
outstanding Securities of such Series, shall no longer be in effect (and the Trustee, at the expense of the Company, shall, at Company Request, execute proper instruments acknowledging the same), except as to: 
  
 (a) the rights of Holders of Securities of such
Series to receive, from the trust funds described in subparagraph (d) hereof, (i) payment of the principal of and each installment of principal of and interest on the outstanding Securities of such Series on the Stated Maturity of such principal or
installment of principal or interest and (ii) the benefit of any mandatory sinking fund payments applicable to the Securities of such Series on the day on which such payments are due and payable in accordance with the terms of this Indenture and the
Securities of such Series; 
  
 (b) the
provisions of Sections 2.4, 2.7, 2.8, 8.2, 8.3 and 8.5; and 
  

 32. 

 (c) the rights, powers, trust and immunities of the Trustee hereunder; provided
that, the following conditions shall have been satisfied: 
  
 (d) the Company shall have deposited or caused to be deposited irrevocably with the Trustee as trust funds in trust for the purpose of making the following payments, specifically pledged as security for and
dedicated solely to the benefit of the Holders of such Securities (i) in the case of Securities of such Series denominated in Dollars, cash in Dollars (or such other money or currencies as shall then be legal tender in the United States) and/or U.S.
Government Obligations, or (ii) in the case of Securities of such Series denominated in a Foreign Currency (other than a composite currency), money and/or Foreign Government Obligations, which through the payment of interest and principal in respect
thereof, in accordance with their terms, will provide (and without reinvestment and assuming no tax liability will be imposed on such Trustee), not later than one day before the due date of any payment of money, an amount in cash, sufficient, in the
opinion of a nationally recognized firm of independent public accountants expressed in a written certification thereof delivered to the Trustee, to pay and discharge each installment of principal (including mandatory sinking fund or analogous
payments) of and interest, if any, on all the Securities of such Series on the dates such installments of interest or principal are due; 
  
 (e) such deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement
or instrument to which the Company is a party or by which it is bound; 
  
 (f) no Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of such deposit or during the period ending on the 91st day after such date;

  
 (g) the Company shall have delivered
to the Trustee an Officers’ Certificate and an Opinion of Counsel to the effect that (i) the Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (ii) since the date of execution of this
Indenture, there has been a change in the applicable Federal income tax law, in either case to the effect that, and based thereon such Opinion of Counsel shall confirm that, the Holders of the Securities of such Series will not recognize income,
gain or loss for Federal income tax purposes as a result of such deposit, defeasance and discharge and will be subject to Federal income tax on the same amount and in the same manner and at the same times as would have been the case if such deposit,
defeasance and discharge had not occurred; 
  
 (h) the Company shall have delivered to the Trustee an Officers’ Certificate stating that the deposit was not made by the Company with the intent of preferring the Holders of the Securities of such Series over any other
creditors of the company or with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; 
  
 (i) such deposit shall not result in the trust arising from such deposit constituting an investment company (as defined in the
Investment Company Act of 1940, as amended), or such trust shall be qualified under such Act or exempt from regulation thereunder; and 
  

 33. 

 (j) the Company shall have delivered to the Trustee an Officers’ Certificate
and an Opinion of Counsel, each stating that all conditions precedent provided for relating to the defeasance contemplated by this Section have been complied with. 
  

	Section	 8.4 Covenant Defeasance. 

  
 Unless this Section 8.4 is otherwise specified pursuant to Section 2.2.21 to be inapplicable to Securities of any Series, on and after the 91st day after
the date of the deposit referred to in subparagraph (a) hereof, the Company may omit to comply with any term, provision or condition set forth under Sections 4.2, 4.3, 4.4, 4.5, 4.6, and 5.1 as well as any additional covenants contained in a
supplemental indenture hereto for a particular Series of Securities or a Board Resolution or an Officers’ Certificate delivered pursuant to Section 2.2.21 (and the failure to comply with any such covenants shall not constitute a Default or
Event of Default under Section 6.1) and the occurrence of any event described in clause (e) of Section 6.1 shall not constitute a Default or Event of Default hereunder, with respect to the Securities of such Series, provided that the following
conditions shall have been satisfied: 
  
 (a)
With reference to this Section 8.4, the Company has deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c) ) with the Trustee as trust funds in trust, specifically pledged as security for, and dedicated solely to,
the benefit of the Holders of such Securities (i) in the case of Securities of such Series denominated in Dollars, cash in Dollars (or such other money or currencies as shall then be legal tender in the United States) and/or U.S. Government
Obligations, or (ii) in the case of Securities of such Series denominated in a Foreign Currency (other than a composite currency), money and/or Foreign Government Obligations, which through the payment of interest and principal in respect thereof,
in accordance with their terms, will provide (and without reinvestment and assuming no tax liability will be imposed on such Trustee), not later than one day before the due date of any payment of money, an amount in cash, sufficient, in the opinion
of a nationally recognized firm of independent certified public accountants expressed in a written certification thereof delivered to the Trustee, to pay principal and interest, if any, on and any mandatory sinking fund in respect of the Securities
of such Series on the dates such installments of interest or principal are due; 
  
 (b) Such deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement
or instrument to which the Company is a party or by which it is bound; 
  
 (c) No Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of such deposit or during the period ending on the 91st day after such date;

  
 (d) the Company shall have delivered
to the Trustee an Opinion of Counsel confirming that Holders of the Securities of such Series will not recognize income, gain or loss for federal income tax purposes as a result of such deposit and defeasance and will be subject to federal income
tax on the same amounts, in the same manner and at the same times as would have been the case if such deposit and defeasance had not occurred; 
  

 34. 

 (e) the Company shall have delivered to the Trustee an Officers’ Certificate
stating the deposit was not made by the Company with the intent of preferring the Holders of the Securities of such Series over any other creditors of the Company or with the intent of defeating, hindering, delaying or defrauding any other creditors
of the Company; and 
  
 (f) The Company
shall have delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that all conditions precedent herein provided for relating to the defeasance contemplated by this Section have been complied with. 

 

	Section	 8.5 Repayment to Company. 

  
 The Trustee and the Paying Agent shall pay to the Company upon request any money held by them for the payment of principal and interest that remains
unclaimed for two years or such other shorter period set forth in applicable escheat or abandoned or unclaimed property law. After that, Securityholders entitled to the money must look to the Company for payment as general creditors unless an
applicable abandoned property law designates another person. 
  

	Section	 8.6 Reinstatement. 

  
 If the Trustee or Paying Agent is unable to apply any money or U.S. Government Obligations in accordance with Sections 8.1, 8.3 or 8.4, as the case may
be, by reason of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or otherwise prohibiting such application, the Company’s obligations under this Indenture and the
Securities shall be revived and reinstated as though no deposit had occurred pursuant to Section 8.1, 8.3 or 8.4, as the case may be, until such time as the Trustee or Paying Agent is permitted to apply all such money or U.S. Government Obligations
in accordance with Section 8.1, 8.3 or 8.4, as the case may be; provided, however, that if the Company makes any payment of principal of, premium, if any, or interest on any Securities because of reinstatement of its obligations, the Company shall
be subrogated to the rights of the holders of such Securities to receive such payment from the money or U.S. Government Obligations held by the Trustee or Paying Agent. 
  
 ARTICLE IX 
  
 AMENDMENTS AND WAIVERS 
  

	Section	 9.1 Without Consent of Holders. 

  
 The Company and the Trustee may amend or supplement this Indenture or the Securities of one or more Series without the consent of any Securityholder:

  
 (a) to cure any ambiguity, defect or
inconsistency; 
  
 (b) to comply with
Article V; 
  
 (c) to provide for
uncertificated Securities in addition to or in place of certificated Securities; 
  

 35. 

 (d) to make any change that does not adversely affect the rights of any
Securityholder in any material respect; 
  
 (e) to provide for the issuance of and establish the form and terms and conditions of Securities of any Series as permitted by this Indenture; 
  

(f) to evidence and provide for the acceptance of appointment hereunder by a successor Trustee with respect to the Securities of
one or more Series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of the trusts hereunder by more than one Trustee; or 
  
 (g) to comply with requirements of the SEC in order
to effect or maintain the qualification of this Indenture under the TIA. 
  

	Section	 9.2 With Consent of Holders. 

  
 The Company and the Trustee may enter into a supplemental indenture with the written consent of the Holders of at least a majority in principal amount of
the outstanding Securities of each Series affected by such supplemental indenture (including consents obtained in connection with a tender offer or exchange offer for the Securities of such Series), for the purpose of adding any provisions to or
changing in any manner or eliminating any of the provisions of this Indenture or of any supplemental indenture or of modifying in any manner the rights of the Securityholders of each such Series. Except as provided in Section 6.13, the Holders of at
least a majority in principal amount of the outstanding Securities of each Series affected by such waiver by notice to the Trustee (including consents obtained in connection with a tender offer or exchange offer for the Securities of such Series)
may waive compliance by the Company with any provision of this Indenture or the Securities with respect to such Series. 
  
 It shall not be necessary for the consent of the Holders of Securities under this Section 9.2 to approve the particular form of any proposed supplemental
indenture or waiver, but it shall be sufficient if such consent approves the substance thereof. After a supplemental indenture or waiver under this section becomes effective, the Company shall mail to the Holders of Securities affected thereby and,
if any Bearer Securities affected thereby are outstanding, publish on one occasion in an Authorized Newspaper, a notice briefly describing the supplemental indenture or waiver. Any failure by the Company to mail or publish such notice, or any defect
therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture or waiver. 
  

	Section	 9.3 Limitations. 

  
 Without the consent of each Securityholder affected, an amendment or waiver may not: 
  
 (a) change the amount of Securities whose Holders must consent to an amendment, supplement or waiver;

  
 (b) reduce the rate of or extend the
time for payment of interest (including default interest) on any Security; 
  

 36. 

 (c) reduce the principal or change the Stated Maturity of any Security or reduce
the amount of, or postpone the date fixed for, the payment of any sinking fund or analogous obligation; 
  
 (d) reduce the principal amount of Discount Securities payable upon acceleration of the maturity thereof; 
  
 (e) waive a Default or Event of Default in the
payment of the principal of or interest, if any, on any Security (except a rescission of acceleration of the Securities of any Series by the Holders of at least a majority in principal amount of the outstanding Securities of such Series and a waiver
of the payment default that resulted from such acceleration); 
  
 (f) make the principal of or interest, if any, on any Security payable in any currency other than that stated in the Security; 
  
 (g) make any change in Sections 6.8, 6.13, 9.3, 10.15 or 10.16; or 
  
 (h) waive a redemption payment with respect to any
Security or change any of the provisions with respect to the redemption of any Securities. 
  

	Section	 9.4 Compliance with Trust Indenture Act. 

  
 Every amendment to this Indenture or the Securities of one or more Series shall be set forth in a supplemental indenture hereto that complies with the TIA
as then in effect. 
  

	Section	 9.5 Revocation and Effect of Consents. 

  
 Until an amendment or waiver becomes effective, a consent to it by a Holder of a Security is a continuing consent by the Holder and every subsequent
Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security, even if notation of the consent is not made on any Security. However, any such Holder or subsequent Holder may revoke the consent as
to his Security or portion of a Security if the Trustee receives the notice of revocation before the date the amendment or waiver becomes effective. 
  
 Any amendment or waiver once effective shall bind every Securityholder of each Series affected by such amendment or waiver unless it is of the type
described in any of clauses (a) through (g) of Section 9.3. In that case, the amendment or waiver shall bind each Holder of a Security who has consented to it and every subsequent Holder of a Security or portion of a Security that evidences the same
debt as the consenting Holder’s Security. 
  

	Section	 9.6 Notation on or Exchange of Securities. 

  
 The Trustee may place an appropriate notation about an amendment or waiver on any Security of any Series thereafter authenticated. The Company in exchange
for Securities of that Series may issue and the Trustee shall authenticate upon request new Securities of that Series that reflect the amendment or waiver. 
  

 37. 

	Section	 9.7 Trustee Protected. 

  
 In executing, or accepting the additional trusts created by, any supplemental indenture permitted by this Article or the modifications thereby of the
trusts created by this Indenture, the Trustee shall be entitled to receive, and (subject to Section 7.1) shall be fully protected in relying upon, an Opinion of Counsel stating that the execution of such supplemental indenture is authorized or
permitted by this Indenture. The Trustee shall sign all supplemental indentures, except that the Trustee need not sign any supplemental indenture that adversely affects its rights. 
  
 ARTICLE X 
  
 MISCELLANEOUS 
  

	Section	 10.1 Trust Indenture Act Controls. 

  
 If any provision of this Indenture limits, qualifies, or conflicts with another provision which is required or deemed to be included in this Indenture by
the TIA, such required or deemed provision shall control. 
  

	Section	 10.2 Notices. 

  
 Any notice or communication by the Company or the Trustee to the other is duly given if in writing and delivered in person or mailed by first-class

  
 if to the Company: 
  
 Nuvelo, Inc. 
 675 Almanor Avenue 
 Sunnyvale, CA 94085

 Attention: General Counsel 
  
 if to the Trustee: 
  
 U.S. Bank National Association 
 60 Livingston
Avenue 
 St. Paul, MN 55107-2292 
 Attention: Frank Leslie 
  
 The Company or the Trustee by
notice to the other may designate additional or different addresses for subsequent notices or communications. 
  
 Any notice or communication to a Securityholder shall be mailed by first-class mail to his address shown on the register kept by the Registrar and, if any
Bearer Securities are outstanding, published in an Authorized Newspaper. Failure to mail a notice or communication to a Securityholder of any Series or any defect in it shall not affect its sufficiency with respect to other Securityholders of that
or any other Series. 
  

 38. 

 If a notice or communication is mailed or published in the manner provided above, within the time
prescribed, it is duly given, whether or not the Securityholder receives it. 
  
 If the Company mails a notice or communication to Securityholders, it shall mail a copy to the Trustee and each Agent at the same time. 
  

	Section	 10.3 Communication by Holders with Other Holders. 

  
 Securityholders of any Series may communicate pursuant to TIA Section 312(b) with other Securityholders of that Series or any other Series with respect to
their rights under this Indenture or the Securities of that Series or all Series. The Company, the Trustee, the Registrar and anyone else shall have the protection of TIA Section 312(c). 
  

	Section	 10.4 Certificate and Opinion as to Conditions Precedent. 

  
 Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the Trustee:

  
 (a) an Officers’ Certificate
stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with; and 
  
 (b) an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent
have been complied with. 
  

	Section	 10.5 Statements Required in Certificate or Opinion. 

  
 Each certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture (other than a certificate provided
pursuant to TIA Section 314(a) (4)) shall comply with the provisions of TIA Section 314(e) and shall include: 
  
 (a) a statement that the person making such certificate or opinion has read such covenant or condition; 
  
 (b) a brief statement as to the nature and scope of
the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based; 
  
 (c) a statement that, in the opinion of such person, he has made such examination or investigation as is necessary to enable him to
express an informed opinion as to whether or not such covenant or condition has been complied with; and 
  
 (d) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with. 

 

 39. 

	Section	 10.6 Rules by Trustee and Agents. 

  
 The Trustee may make reasonable rules for action by or a meeting of Securityholders of one or more Series. Any Agent may make reasonable rules and set
reasonable requirements for its functions. 
  

	Section	 10.7 Legal Holidays. 

  
 Unless otherwise provided by Board Resolution, Officers’ Certificate or supplemental indenture for a particular Series, a “Legal Holiday”
is any day that is not a Business Day. If a payment date is a Legal Holiday at a place of payment, payment may be made at that place on the next succeeding day that is not a Legal Holiday, and no interest shall accrue for the intervening period.

  

	Section	 10.8 No Recourse Against Others. 

  
 A director, officer, employee or stockholder, as such, of the Company shall not have any liability for any obligations of the Company under the Securities
or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. Each Securityholder by accepting a Security waives and releases all such liability. The waiver and release are part of the consideration
for the issue of the Securities. 
  

	Section	 10.9 Counterparts. 

  
 This Indenture may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed shall be
deemed to be an original and all of which taken together shall constitute one and the same agreement. 
  

	Section	 10.10 Governing Laws. 

  
 THIS INDENTURE AND THE SECURITIES SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO AGREEMENTS MADE AND TO BE PERFORMED IN SUCH STATE,
WITHOUT REGARD TO THE CONFLICT OF LAWS PROVISIONS THEREOF. 
  

	Section	 10.11 No Adverse Interpretation of Other Agreements. 

  
 This Indenture may not be used to interpret another indenture, loan or debt agreement of the Company or a Subsidiary. Any such indenture, loan or debt
agreement may not be used to interpret this Indenture. 
  

	Section	 10.12 Successors. 

  
 All agreements of the Company in this Indenture and the Securities shall bind its successor. All agreements of the Trustee in this Indenture shall bind
its successor. 
  

 40. 

	Section	 10.13 Severability. 

  
 In case any provision in this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby. 
  

	Section	 10.14 Table of Contents, Headings, Etc. 

  
 The Table of Contents, Cross Reference Table, and headings of the Articles and Sections of this Indenture have been inserted for convenience of reference
only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 
  

	Section	 10.15 Securities in a Foreign Currency or in ECU. 

  
 Unless otherwise specified in a Board Resolution, a supplemental indenture hereto or an Officers’ Certificate delivered pursuant to Section 2.2 of
this Indenture with respect to a particular Series of Securities, whenever for purposes of this Indenture any action may be taken by the Holders of a specified percentage in aggregate principal amount of Securities of all Series or all Series
affected by a particular action at the time outstanding and, at such time, there are outstanding Securities of any Series which are denominated in a coin or currency other than Dollars (including ECUs), then the principal amount of Securities of
such Series which shall be deemed to be outstanding for the purpose of taking such action shall be that amount of Dollars that could be obtained for such amount at the Market Exchange Rate at such time. For purposes of this Section 10.15,
“Market Exchange Rate” shall mean the noon Dollar buying rate in New York City for cable transfers of that currency as published by the Federal Reserve Bank of New York; provided, however, in the case of ECUs, Market Exchange Rate shall
mean the rate of exchange determined by the Commission of the European Union (or any successor thereto) as published in the Official Journal of the European Union (such publication or any successor publication, the “Journal”). If such
Market Exchange Rate is not available for any reason with respect to such currency, the Trustee shall use, in its sole discretion and without liability on its part, such quotation of the Federal Reserve Bank of New York or, in the case of ECUs, the
rate of exchange as published in the Journal, as of the most recent available date, or quotations or, in the case of ECUs, rates of exchange from one or more major banks in The City of New York or in the country of issue of the currency in question
or, in the case of ECUs, in Luxembourg or such other quotations or, in the case of ECUs, rates of exchange as the Trustee, upon consultation with the Company, shall deem appropriate. The provisions of this paragraph shall apply in determining the
equivalent principal amount in respect of Securities of a Series denominated in currency other than Dollars in connection with any action taken by Holders of Securities pursuant to the terms of this Indenture. 
  
 All decisions and determinations of the Trustee regarding the Market Exchange
Rate or any alternative determination provided for in the preceding paragraph shall be in its sole discretion and shall, in the absence of manifest error, be conclusive to the extent permitted by law for all purposes and irrevocably binding upon the
Company and all Holders. 
  

 41. 

	Section	 10.16 Judgment Currency. 

  
 The Company agrees, to the fullest extent that it may effectively do so under applicable law, that (a) if for the purpose of obtaining judgment in any
court it is necessary to convert the sum due in respect of the principal of or interest or other amount on the Securities of any Series (the “Required Currency”) into a currency in which a judgment will be rendered (the “Judgment
Currency”), the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee could purchase in The City of New York the Required Currency with the Judgment Currency on the day on which final
unappealable judgment is entered, unless such day is not a New York Banking Day, then, the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee could purchase in The City of New York the Required
Currency with the Judgment Currency on the New York Banking Day preceding the day on which final unappealable judgment is entered and (b) its obligations under this Indenture to make payments in the Required Currency (i) shall not be discharged or
satisfied by any tender, any recovery pursuant to any judgment (whether or not entered in accordance with clause (a) ), in any currency other than the Required Currency, except to the extent that such tender or recovery shall result in the actual
receipt, by the payee, of the full amount of the Required Currency expressed to be payable in respect of such payments, (ii) shall be enforceable as an alternative or additional cause of action for the purpose of recovering in the Required Currency
the amount, if any, by which such actual receipt shall fall short of the full amount of the Required Currency so expressed to be payable, and (iii) shall not be affected by judgment being obtained for any other sum due under this Indenture. For
purposes of the foregoing, “New York Banking Day” means any day except a Saturday, Sunday or a legal holiday in The City of New York on which banking institutions are authorized or required by law, regulation or executive order to close.

  
 ARTICLE XI 
  
 SINKING FUNDS 
  

	Section	 11.1 Applicability of Article. 

  
 The provisions of this Article shall be applicable to any sinking fund for the retirement of the Securities of a Series, except as otherwise permitted or
required by any form of Security of such Series issued pursuant to this Indenture. 
  
 The minimum amount of any sinking fund payment provided for by the terms of the Securities of any Series is herein referred to as a “mandatory sinking fund payment” and any other amount provided for by the
terms of Securities of such Series is herein referred to as an “optional sinking fund payment.” If provided for by the terms of Securities of any Series, the cash amount of any sinking fund payment may be subject to reduction as provided
in Section 11.2. Each sinking fund payment shall be applied to the redemption of Securities of any Series as provided for by the terms of the Securities of such Series. 
  

 42. 

	Section	 11.2 Satisfaction of Sinking Fund Payments with Securities. 

  
 The Company may, in satisfaction of all or any part of any sinking fund payment with respect to the Securities of any Series to be made pursuant to the
terms of such Securities 
  
 (1) deliver outstanding Securities of
such Series to which such sinking fund payment is applicable (other than any of such Securities previously called for mandatory sinking fund redemption) and (2) apply as credit Securities of such Series to which such sinking fund payment is
applicable and which have been redeemed either at the election of the Company pursuant to the terms of such Series of Securities (except pursuant to any mandatory sinking fund) or through the application of permitted optional sinking fund payments
or other optional redemptions pursuant to the terms of such Securities, provided that such Securities have not been previously so credited. Such Securities shall be received by the Trustee, together with an Officers’ Certificate with respect
thereto, not later than 15 days prior to the date on which the Trustee begins the process of selecting Securities for redemption, and shall be credited for such purpose by the Trustee at the price specified in such Securities for redemption through
operation of the sinking fund and the amount of such sinking fund payment shall be reduced accordingly. If as a result of the delivery or credit of Securities in lieu of cash payments pursuant to this Section 11.2, the principal amount of Securities
of such Series to be redeemed in order to exhaust the aforesaid cash payment shall be less than $100,000, the Trustee need not call Securities of such Series for redemption, except upon receipt of a Company Order that such action be taken, and such
cash payment shall be held by the Trustee or a Paying Agent and applied to the next succeeding sinking fund payment, provided, however, that the Trustee or such Paying Agent shall from time to time upon receipt of a Company Order pay over and
deliver to the Company any cash payment so being held by the Trustee or such Paying Agent upon delivery by the Company to the Trustee of Securities of that Series purchased by the Company having an unpaid principal amount equal to the cash payment
required to be released to the Company. 
  

	Section	 11.3 Redemption of Securities for Sinking Fund. 

  
 Not less than 45 days (unless otherwise indicated in the Board Resolution, supplemental indenture hereto or Officers’ Certificate in respect of a
particular Series of Securities) prior to each sinking fund payment date for any Series of Securities, the Company will deliver to the Trustee an Officers’ Certificate specifying the amount of the next ensuing mandatory sinking fund payment for
that Series pursuant to the terms of that Series, the portion thereof, if any, which is to be satisfied by payment of cash and the portion thereof, if any, which is to be satisfied by delivering and crediting of Securities of that Series pursuant to
Section 11.2, and the optional amount, if any, to be added in cash to the next ensuing mandatory sinking fund payment, and the Company shall thereupon be obligated to pay the amount therein specified. Not less than 30 days (unless otherwise
indicated in the Board Resolution, Officers’ Certificate or supplemental indenture in respect of a particular Series of Securities) before each such sinking fund payment date the Trustee shall select the Securities to be redeemed upon such
sinking fund payment date in the manner specified in Section 3.2 and cause notice of the redemption thereof to be given in the name of and at the expense of the Company in the manner provided in Section 3.3. Such notice having been duly given, the
redemption of such Securities shall be made upon the terms and in the manner stated in Sections 3.4, 3.5 and 3.6. 
  

 43. 

 IN WITNESS WHEREOF, the parties hereto
have caused this Indenture to be duly executed as of the day and year first above written. 
  

			
	 NUVELO, INC.

		
	By:	 	 
		
	Name:	 	 
		
	Its:	 	 

  

			
	
	 U.S. BANK NATIONAL ASSOCIATION

		
	By:	 	 
		
	Name:	 	 
		
	Its:	 	 

  

 44.

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