Document:

Exhibit 10.96

 

Exhibit 10.96

STANDARD LEASE SUMMARY

THIS LEASE is made as of this 31st  day of  January, 2007
between the following parties:

	 	 	 
	LANDLORD:

	 	TENANT:
	DOMINO’S FARMS OFFICE PARK, L.L.C.

	 	AASTROM BIOSCIENCES, INC.
	(a Michigan corporation)

	 	(a Michigan corporation)
	Post Office Box 445

	 	Post Office Box 376
	24 Frank Lloyd Wright Drive

	 	24 Frank Lloyd Wright Drive
	Ann Arbor, Michigan 48106

	 	Ann Arbor, Michigan 48106

The following is intended to summarize certain basic terms of this Lease, and is not intended to be
exhaustive. In the event anything set forth in this Lease Summary (“Lease Summary”) conflicts with
the other specific provisions of this Lease contained in the Standard Lease Terms, the latter shall
be deemed to control.

	A.	 	BUILDING:
	 
	 	 	The office building commonly known as Domino’s Farms Prairie House located at 24 Frank Lloyd
Wright Drive, Ann Arbor, Michigan 48106.
	 
	B.	 	PREMISES:

	 	 	 
	Lobby K, Level 2:

	 	Approximately 32,708 rentable square feet based upon 29,735 usable
square feet, plus a 10% common area factor.
	 
	 	 
	Lobby K, Level 1:

	 	Approximately 589 usable square feet. (Mechanical room).
	 
	 	 
	Lobby K, Level 1:

	 	Approximately 3234 usable square feet. (Storage rooms).

	C.	 	TERM:
	 
	 	 	Commencement Date:
	 
	 	 	For the Level 1 Storage Rooms, the Commencement Date shall be the same as the date of
execution of this Lease.

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	 	 	For the Level 1 Mechanical Room, the Commencement Date shall be the day following the
receipt of a Temporary Certificate of Occupancy from the Ann Arbor Township Building
Inspector for Phase 1 of the Level 2 suite, estimated to be approximately March 29, 2007.
	 
	 	 	For Phase 1 of the Level 2 suite, which is approximately 3,904 usable square feet, the
Commencement Date shall be the day following the receipt of a Temporary Certificate of
Occupancy from the Ann Arbor Township Building Inspector for said space, estimated to be
approximately March 29, 2007.
	 
	 	 	For Phase 2 of the Level 2 suite, which is approximately 20,906 usable square feet, the
Commencement Date shall be the day following the receipt of a Temporary Certificate of
Occupancy from the Ann Arbor Township Building Inspector for said space, estimated to be
approximately May 1, 2007.
	 
	 	 	For Phase 3 of the Level 2 suite, which is approximately 4,925 usable square feet, the
Commencement Date shall be the day following the receipt of a Final Certificate of Occupancy
from the Ann Arbor Township Building Inspector for said space, estimated to be approximately
May 15, 2007.
	 
	 	 	Expiration Date:
	 
	 	 	Six (6) years following the Commencement Date for Phase 3 of the Level 2 suite.
	 
	 	 	Options:
	 
	 	 	Two (2) five-year options exercisable upon six (6) months prior written notice to Landlord.
	 
	E.	 	RENT:

	 	 	 
	Year 1

	 	Level 2 suite: $30.83 per rentable square foot

Level 1 rooms: $10.28 per usable square foot
	 
	 	 
	Years 2 — 5:

	 	Rent shall be adjusted each year by the amount of the Consumers
Price Index for the Detroit Metropolitan area (“CPI”) for the previous calendar year.
In no year will the rent be decreased from the previous year. If at any time
during the term hereof the United States Bureau of Labor Statistics shall discontinue
the issuance of the CPI, then the parties agree to use any other standard, nationally
recognized cost of living index then issued and available, which is published by the
United States Government, and if no governmental index is then published, then by any

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	 	generally recognized privately published index of the cost of living.
If the adjustment in annualized Base Rent for any new twelve (12)
month period has not been calculated prior to the due date of the
monthly installment of minimum net rent for such month, the relevant
monthly installment shall be paid based on the prior year’s
annualized base rent until such time as the new base rent has been
established, and the shortfall, if any, shall be paid with the first
monthly installment for which the revised minimum base rent has been
established.

	E.	 	PERMITTED USES:
	 
	 	 	General office, lab, manufacturing, material storage and shipping.
	 
	F.	 	SECURITY DEPOSIT:
	 
	 	 	Not applicable.
	 
	G.	 	LANDLORD’S AGENT:
	 
	 	 	Domino’s Farms Corporation
	 
	H.	 	MAILING ADDRESS:
	 
		 	24 Frank Lloyd Wright Drive

P.O. Box 445

Ann Arbor, MI 48106-0445

RIDERS ATTACHED:

	 	 	 
	Rider A

	 	Office Location
	Rider B

	 	Rules and Regulations
	Rider C

	 	Work Agreement
	Rider D

	 	Additional Provisions
	Rider E

	 	Hazardous Materials

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TABLE OF CONTENTS

	 	 	 
	Section	 	Page
	 
	 	 
	1.   Definitions/Lease
	 	1
	2.   Amenities and Common Area
	 	1
	3.   The Term
	 	1
	4.   The Base Rent
	 	2
	5.   Late Charges and Interest
	 	3
	6.   Taxes and Assessments
	 	3
	7.   Utilities and Utility Expenses
	 	3
	8.   Insurance
	 	4
	9.   Payment for Services Rendered by Landlord
	 	5
	10. Use of Premises
	 	6
	11. Damage
	 	6
	12. Maintenance and Repairs
	 	7
	13. Leasehold Improvements
	 	8
	14. Alterations
	 	9
	15. Liens
	 	10
	16. Eminent Domain
	 	10
	17. Assignment or Subletting
	 	11
	18. Inspection and Alteration of Public Portions
	 	11
	19. Fixtures and Equipment
	 	13
	20. Notices or Demands
	 	13
	21. Breach; Insolvency; Re-Entry
	 	14
	22. Surrender of Premises on Termination
	 	15
	23. Performance by Landlord of the Covenants of Tenant
	 	16
	24. Subordination; Estoppel Certificates
	 	17
	25. Substitute Space
	 	17
	26. Quiet Enjoyment
	 	17
	27. Holding Over
	 	17
	28. Remedies Not Exclusive; Waiver
	 	18
	29. Waiver of Subrogation
	 	18
	30. Indemnification
	 	18
	31. Assignment by Landlord
	 	19
	32. Security Deposit
	 	19
	33. Hazardous Materials
	 	20
	34. Movement of Tenant’s Property
	 	21
	35. Non-Terminability Compliance With Laws, Costs, Severability
	 	22
	36. Entire Agreement
	 	22
	37. Recording
	 	22
	38. General
	 	22
	Rider A Location of Premises
	 	25
	Rider B Rules and Regulations
	 	27
	Rider C Work Agreement
	 	30
	Rider D Additional Provisions
	 	33
	Rider E Hazardous Materials
	 	34

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STANDARD LEASE TERMS

SECTION 1

Definitions/Lease

	1.01	 	Definitions: In addition to words and phrases defined in these Standard Lease
Terms, the words and phrases in the Summary of Lease Terms shall have the meanings set forth
therein.
	 
	1.02	 	Lease of Premises: In consideration of the rents to be paid and the covenants and
agreements to be performed hereunder, Landlord hereby leases to Tenant and Tenant hereby
leases from Landlord the Premises.

SECTION 2

Amenities and Common Area

	2.01	 	Amenities: Tenant’s lease of the Premises shall include the nonexclusive right to
the use of such building amenities as are generally made available to tenants of the Building.
The use and the availability of all such amenities shall be subject to the reasonable rules
and regulations established by Landlord or the respective proprietor or operator of such
amenities and subject to such prices or fees as may be established from time to time for the
use of any amenity. In addition, Tenant shall be entitled to unreserved parking spaces in the
parking area provided for the Building, together with the nonexclusive right to use the
walkways and other means of ingress and egress over the land surrounding the Building, and all
other rights of ingress and egress provided for use in common by all owners and tenants of the
Building.
	 
	2.02	 	Common Area: The term “Common Area” means that part of the Building intended by
Landlord for the common use of all tenants, including, but not limited to, lobbies, public
entrances, restrooms, stairways, elevators, corridors, parking areas and walkways. Tenant,
and its employees, guests, invitees and licensees, shall have the nonexclusive right to use
the Common Area with other tenants and other persons permitted by Landlord to use the same.
Tenant shall not take any action which would interfere with the rights of other persons to use
the Common Area.

SECTION 3

The Term

	3.01	 	Term: The Term of this Lease and the payment of rent hereunder, shall commence on
the Commencement Date and shall end on the Expiration Date as

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	 	 	set forth on the Standard Lease Summary, unless terminated by Tenant in accordance with
Section 3.04 below.
	 
	3.02	 	Waivers: Tenant expressly waives any right to rescind this Lease and further
expressly waives the right to recover any damages, direct or indirect, which may
result from Landlord’s failure to deliver possession of the Premises on the
Commencement Date. The Commencement Date shall not be postponed or delayed by reason of or
arising out of delays occasioned by Tenant.
	 
	3.03	 	Options Provided Tenant is not in default under this Lease beyond the applicable
cure period at the time of exercise of the option, Tenant shall have two (2) options to extend
the term of this Lease for an additional five (5) years (each an “Option Period”),
such Option Periods to begin upon the expiration of the Lease Term or Option Period, as the
case may be. If Tenant shall elect to exercise such option to renew, it shall do so by giving
written notice to Landlord not less than six (6) months before the expiration of the original
Term or Option Period, as the case may be (the “Exercise Notice”). Except for the
Base Annual Rent, all terms and conditions of the Lease shall apply during each Option Period
and Tenant shall accept the Leased Premises in its then “AS IS” condition; provided, however,
that the foregoing shall not affect Landlord’s obligations with regard to maintenance and
repair of the Leased Premises.
	 
	3.04	 	Tenant’s Right to Terminate. Intentionally omitted.
	 
	3.05	 	Right of First Refusal: See Rider D, Additional Provisions.

SECTION 4

The Base Rent

	4.01	 	Base Annual Rental: Tenant agrees to pay to Landlord the Base Annual Rental
for the original Term of this Lease without right of set-off or abatement (except as expressly
permitted under this Lease).
	 
	4.02	 	Base Monthly Rental: The Base Annual Rental shall be payable in monthly
installments equal to the Base Monthly Rental, in advance, without any set-offs or deductions
(except as expressly permitted under this Lease), on the first day of each month (the “Rent
Day”) during the Term of this Lease at the mailing address shown in Paragraph I of the
Summary, or at such other place as Landlord from time to time may designate in writing. In
the event the Commencement Date is other than the first day of the calendar month, the Base
Monthly Rental for the first and last partial months shall be prorated based on the actual
number of days of such months included within the Lease Term and based upon the amount of the
Base Monthly Rental.

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SECTION 5

Late Charges and Interest

	5.01	 	Late Charges: Any rent or other sums payable by Tenant to Landlord under this
Lease which are not paid by Tenant and received and accepted by Landlord within seven (7)
days after they are due will be subject to a one-time late charge of five percent (5%) of the
amount due. Such late charges will be due and payable as additional rent on or before the
next Rent Day.
	 
	5.02	 	Interest: Any rent, late charges or other sums, if any, payable by Tenant to
Landlord under this Lease not paid within thirty (30) days after the same are due will bear
interest at a per annum rate of eleven percent (11%); provided however, if such rate exceeds
the maximum rate of interest permitted by law under such circumstances, then such rate shall
be reduced to the maximum permissible rate. Such interest will be due and payable as
additional rent on or before the next Rent Day, and will accrue from the date that such rent,
late charges or other sums are first payable under the provisions of this Lease until actually
paid by Tenant.
	 
	5.03	 	Default: Any default in the payment of rent, late charges or other sums will not
be considered cured unless and until the late charges and interest due hereunder are paid by
Tenant to Landlord. If Tenant defaults in paying such late charges and/or interest, Landlord
will have the same remedies as on default in the payment of rent. The obligation hereunder to
pay late charges and interest exists in addition to, and not in the place of, the other
default provisions of this Lease.

SECTION 6

Taxes and Assessments

	6.01	 	Personal Property Taxes: Tenant shall be responsible for and pay all personal
property taxes assessed against Tenant’s fixtures, equipment and other property of Tenant
located on the Premises.
	 
	6.02	 	Real Property Taxes: Landlord shall, at its sole cost and expense, pay all real
property taxes and assessments levied against the Building and Common Areas.

SECTION 7

Utilities and Utility Expenses

	7.01	 	Telecommunications: Tenant shall arrange for and pay for the installation of
telephone and other telecommunications services to the Premises, subject to Landlord’s prior
written approval of the means of installation of such service(s).

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	7.02	 	Utilities to be Furnished: So long as Tenant is not in default under the terms of
this Lease, Landlord shall furnish, at its sole cost and expense, the following utilities as
required for comfortable occupancy of the Premises (“Utilities”):

	 	A.	 	Electricity for usual office requirements and as necessary for Tenant’s use of
the Premises as more particularly set forth in the Work Agreement;
	 
	 	B.	 	Air conditioning and heat during the appropriate season, as provided in the
Rules and Regulations attached as Rider B; and
	 
	 	C.	 	Hot and cold water for kitchen purposes.

	7.03	 	Interruption of Utilities: Interruption or curtailment of any Utility for any
reason or interruption or curtailment of any service maintained in the Building, if
caused by strikes, mechanical difficulties, or any causes or acts beyond Landlord’s
reasonable control, whether similar or dissimilar to those enumerated, shall not entitle
Tenant to any claim against Landlord or to any abatement in rent, nor shall the same
constitute constructive or partial eviction, unless Landlord fails to take such measures as
may be reasonable in the circumstances to restore the service or Utility without undue delay.
If the Premises are rendered untenantable in whole or in part for a period of over three (3)
full business days, by the making of repairs, replacements or additions (other than those made
at Tenant’s request or caused by misuse or neglect by Tenant or Tenant’s agents, servants,
visitors, invitees, licensees or employees or those required by any governmental authority due
to the nature of Tenant’s use of the Premises), or if Landlord fails to make such repairs,
replacements or additions as necessary to restore the Utility service after Tenant gives
Landlord written notice, there shall be a proportionate abatement of rent during the period of
such untenantability. Except in cases of emergency, Landlord shall give Tenant reasonable
prior notice of any delay or diminution in any Utility service and shall use commercially
reasonable efforts to minimize any inconvenience to Tenant where such delay or diminution is
the result of Landlord’s voluntary actions.

SECTION 8

Insurance

	8.01	 	Liability Insurance: Tenant shall obtain, at its own expense, comprehensive general
liability insurance coverage, including blanket contractual coverage, against claims for or
arising out of bodily injury, death or property damage occurring in, on or about the Premises,
which policy or policies shall name Landlord as an additional insured. The policy may be
either a dual limit policy in the amounts of $1,000,000 per person and $1,000,000 per
occurrence for bodily injury and $1,000,000 per occurrence for property damage or a single
limit policy in the amount of $1,000,000. Landlord may require that the limits of such
insurance be increased in reasonably appropriate amounts as may be

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	 	 	determined by Landlord or any mortgagee of the Building; provided, however, that the amount
of coverage will not be increased more frequently than at one (1) year intervals. Such
policy shall be issued by an insurance company reasonably acceptable to Landlord. The
policy procured by Tenant under this Subsection 8.01 must provide for at least thirty (30)
days written notice to Landlord of any cancellation. On or before the Commencement Date,
Tenant shall deliver to Landlord, at Landlord’s option, a certificate of insurance or a
certified copy of the original policy, together with receipts evidencing payment of the
premiums therefore. Tenant will deliver certificates of renewal for such policies to
Landlord at least thirty (30) days prior to the expiration dates thereof. The insurance
provided by Tenant under this Subsection 8.01 may be in the form of a blanket insurance
policy covering other properties as well as the Premises; provided, however, that Tenant
must furnish Landlord with a written statement from the insurer(s) under such policy or
policies which statement shall (i) specify the policy limits of the policy or policies, (ii)
state that the Premises and this Lease are covered by such policy or policies and (iii)
state the amount of total insurance allocated to the Premises; provided, further, that any
such policy or policies of blanket insurance must, as to the Premises, otherwise comply as
to insurance amounts, endorsements, notice of cancellation and coverage with the other
provisions of this Subsection 8.01.
	 
	8.02	 	Insurance for Leasehold Improvements: Tenant shall obtain, at its own expense, a
policy to insure the leasehold improvements to be made to the Premises and any other fixtures
or equipment of Tenant which will remain the property of Landlord under Section 19 of this
Lease. The policy shall name Landlord as an additional insured for full replacement cost
against loss by fire, with standard extended risk coverage, vandalism, malicious mischief,
sprinkler leakage and all other risk perils.
	 
	8.03	 	Replacement Cost: Tenant shall at all times maintain insurance for full replacement
cost of property of Tenant located in or about the Premises.
	 
	8.04	 	Landlord’s Insurance: During the term of this Lease, Landlord shall, at its sole
cost and expense, procure and maintain (i) general liability insurance for the Common Areas
and Building, including coverage for personal injury and property damage; (ii) fire and
extended coverage insurance for the Building equal to the full replacement value of the
Building, including umbrella coverage and (iii) rental interruption insurance.

SECTION 9

Payment for Services Rendered by Landlord

	9.01	 	Payment for Services: If Landlord at any time, subject to the notice and cure
provisions of Section 23.01 below, (i) does any work or performs any service in connection
with the Premises, or (ii) supplies any materials to the

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	 	 	Premises, and the cost of such services, work or materials is Tenant’s responsibility under
the provisions of this Lease, Landlord will invoice Tenant for the reasonable cost, payable
on the next Rent Day or within thirty (30) days after delivery of the invoice, whichever is
later. This Section 9.01 will apply to any such work, service or materials, whether
furnished at Tenant’s request or on its behalf and whether furnished or caused to be
furnished by Landlord, its agents, employees or contractors. All amounts payable under this
Section 9.01 will be additional rental and failure by Tenant to pay them when due will be a
default under this Lease and, in addition to any other remedies provided in this Lease upon
default, will result in the assessment of late charges and interest under Section 5.

SECTION 10

Use of Premises

	10.01	 	Permitted Uses: The Premises will be used and occupied by Tenant for the
Permitted Uses and for no other purpose without prior written consent of Landlord, which
consent shall not be unreasonably withheld, conditioned or delayed. Tenant agrees that it
will not use or permit any person to use the Premises or any part thereof for any use or
purposes in violation of the laws of the United States, the laws, ordinances or other
regulations of the state and municipality in which the Premises are located, or of any other
lawful authorities. During the Term or any extension, Tenant will comply with all lawful
health and police regulations and with the Rules and Regulations attached as Rider B.
	 
	10.02	 	Rules and Regulations: The Landlord may, from time to time, establish reasonable
rules and regulations (“Rules and Regulations”) for use of the Premises, the Building and the
Common Areas by Tenant and all other persons. Those Rules and Regulations in effect on the
date of this Lease are attached as Rider B. All such rules and regulations may be amended or
replaced, at Landlord’s option, upon written notice to Tenant (sent by mail or otherwise
delivered to the Premises). All such amendments or replacements shall be deemed to
automatically amend and replace those Rules and Regulations set forth in Rider B.

SECTION 11

Damage

	11.01	 	Damage: If the Premises are damaged or destroyed in whole or in part by any fire or
other casualty during the Term hereof, Landlord will repair and restore the same to good
tenantable condition with reasonable dispatch (not to exceed two hundred seventy (270) days),
the rent herein provided for shall abate entirely in case the entire Premises are untenantable
and prorata on an equitable basis for the portion rendered untenantable, in case a part only
is untenantable, until the

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	 	 	same shall be restored to a tenantable condition. If such repairs cannot, in Landlord’s
reasonable opinion, be made with two hundred seventy (270) days, then either Landlord or
Tenant (without payment of the Termination Fee) shall have the right, by written notice
given to the other within seventy five (75) days after the date of the damage or
destruction, to terminate this Lease as of the date of the damage or destruction and any
rent attributable to a period of time after such damage or destruction shall be remitted by
Landlord to Tenant. Landlord shall, within forty five (45) days after such damage or
destruction give Tenant written notice as to whether, in Landlord’s reasonable opinion, the
Premises can be restored within two hundred seventy (270) days after the date of the damage
or destruction. If neither party elects to terminate this Lease pursuant to this Section
11.01, Landlord shall repair the Premises in accordance with this Section 11.01. The
foregoing shall be subject to all of the following: (i) if Tenant shall fail to adjust its
own insurance or to remove its damaged goods, wares, equipment or property within a
reasonable time, and as a result thereof the repairing and restoration is delayed, there
shall be no abatement of rental during the period of such resulting delay; (ii) that there
shall be no abatement of rental if such fire or other cause damaging or destroying the
Premises shall result from the negligence or willful act of Tenant, its agents, servants,
licensees, or employees; (iii) that if Tenant shall use any part of the Building other than
the Premises for storage, during the period of repair, a reasonable charge shall be made
therefore against Tenant; (iv) that in case the Premises or the Building shall be destroyed
to the extent of more than one-half (1/2) of the full insurable value thereof, Landlord may
at its option terminate this Lease forthwith by a written notice to Tenant within forty five
(45) days after the date of the damage or destruction.

SECTION 12

Maintenance and Repairs

	12.01	 	Maintenance and Repairs: Landlord will, at its sole cost and expense, maintain,
repair and keep all structural, electrical, mechanical and plumbing systems of the Building
(other than such systems installed by Tenant) and any other improvements on the land which
serve the entire Building, including the parking lot, at all times, in compliance with all
applicable laws, and in good condition and repair, except for reasonable and normal wear and
tear.
	 
	 	 	Landlord will also, at its sole cost and expense, maintain, repair and replace the grounds,
sidewalks, driveways and parking areas serving the Building in compliance with all
applicable laws, and in good condition and repair, except for reasonable wear and tear.
Landlord assumes, at its sole cost and expense, the responsibility for the operation,
security, management, maintenance and repair of the Common Area. The Common Area shall be
maintained in compliance with all applicable laws, and in good condition and repair, except
for reasonable and normal wear and tear.

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	12.02	 	Cost of Repairs: From and after the Commencement Date, any repairs, additions or
alterations to the Building including any of its systems (e.g., plumbing, electrical,
mechanical) structural or non-structural, or to the Premises, which are required by any law,
statute, ordinance, rule, regulation or governmental authority or insurance carrier,
including, without limitation, OSHA, arising exclusively out of Tenant’s use or occupancy of
the Premises, will be made by Landlord at Tenant’s expense including, without limitation,
those which require the making of any structural, unforeseen or extraordinary changes. The
foregoing shall not apply to any such repairs that are required because of Landlord’s use of
the Building generally as an office building. Tenant agrees to pay the total costs incurred
by Landlord for repairs made under this Subsection 12.02 within thirty (30) days after the
delivery of an invoice for same. All amounts payable under this Section 12.02 will be
additional rental and failure by Tenant to pay them when due will be a default under this
Lease and, in addition to any other remedies provided in this Lease upon default, will result
in the assessment of late charges and interest as set forth in Section 5. Notwithstanding the
foregoing, Landlord shall give Tenant written notice prior to expending any sums necessitated
by Tenant’s use and Tenant shall have the right to contest any alleged violation in good
faith, including, without limitation, the right to apply for and obtain a waiver or deferment
of compliance, the right to assert any and all defenses allowed by applicable laws and the
right to appeal any decisions, judgments or rulings to the fullest extent permitted by
applicable laws.
	 
	12.03	 	Maintenance: Except as otherwise provided in this Lease, Tenant agrees at its own
expense to maintain the Premises and all improvements thereto, including any improvements made
by Tenant, at all times in good condition and repair except for reasonable and normal wear and
tear, and damage caused by fire or other casualty.
	 
	12.04	 	Janitorial Services: Landlord will provide janitorial services to the Premises in
accordance customary standards for the Building.

SECTION 13

Leasehold Improvements

	13.01	 	Plans/Allowance: Landlord and Tenant agree that the Premises may be improved
(“Leasehold Improvements”) in accordance with certain plans and specifications to be prepared
by Tenant or Tenant’s agents, which plans and specifications shall be subject to Landlord’s
reasonable prior approval in the same manner as provided in Section 14.01.
	 
	13.02	 	Construction: Any improvements to be made to the Premises pursuant to Tenant’s
approved plans and specifications shall be constructed by Landlord and

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	 	 	any contractors pursuant to the Work Agreement to be entered into by Landlord and Tenant in
the form attached as Rider C.

SECTION 14

Alterations

	14.01	 	Alterations: Landlord must review plans for and approve any structural alterations,
additions, or improvements, exterior or interior, to the Premises including alterations made
at the request of Tenant. Landlord’s consent for any interior improvements will not be
unreasonably withheld, conditioned or delayed; provided that Landlord’s consent to exterior
improvements may be withheld in Landlord’s sole and absolute discretion. Any modification of
the Premises other than as specifically set forth in the Work Agreement as Landlord’s expense
will be at the expense of Tenant. All work will be done in accordance with the Building
Interior Specifications document(s) which can be obtained by Tenant from Landlord.
Notwithstanding the foregoing, Tenant may, with Landlord’s consent, install or replace
carpeting within the Premises, paint all or any portion of the walls of the Premises, or make
minor, non-structural alterations which do not adversely affect the base building systems,
including but not limited to alterations to Tenant’s phone, data or audio/visual system or
infrastructure, provided all such carpeting, paint or other alterations meet or exceed the
applicable building standard. Tenant must notify the Landlord prior to the commencement of
any work, and all modifications must adhere to the Build Interior Specifications document
referenced above.

	14.02	 	Restoration of Premises: All alterations, additions and improvements made by
either of the parties hereto on the Premises after the date hereof will be the property of
Landlord and will remain on and be surrendered with the Premises at the termination of this
Lease provided, however, that except for the work being performed under the Work Agreement,
Tenant shall remove, at Landlord’s option, all alterations, additions or improvements to the
Premises made for Tenant after the date hereof and Tenant shall pay to Landlord to restore the
Premises to the Premises’ original condition. Notwithstanding the foregoing, in the event
that Landlord gives its consent, pursuant to the provisions of this Section 14, to allow
Tenant to make an alteration in the Premises after the date hereof, Landlord agrees, upon
Tenant’s written request, to notify Tenant in writing at the same time of the giving of such
consent whether Landlord will require Tenant, at Tenant’s cost, to remove such alteration at
the end of the Lease Term. In addition, in the event that Landlord’s consent to an alteration
by Tenant is not necessary under Section 14, Landlord agrees, promptly after Tenant notifies
Landlord in writing of the alteration that Tenant intends to make, to notify Tenant in writing
whether Landlord will require Tenant, at Tenant’s cost, to remove such alteration at the end
of the Lease Term.

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SECTION 15

Liens

	15.01	 	Liens: Tenant will keep the Building, Premises and surrounding land free of liens
of any sort attributable to the acts of Tenant and will hold Landlord harmless from any liens
which may be placed on the Building, Premises or surrounding land due to the acts of Tenant
and except those attributable to the acts of Landlord or other tenants, or any party claiming
by through or under Landlord.

SECTION 16

Eminent Domain

	16.01	 	Eminent Domain: If the Premises are taken by any public authority under power of
eminent domain, or by private sale in lieu of eminent domain, this Lease will
terminate as of the date of such taking or sale, and Tenant may receive a prorata refund of
any rents, deposits or other sums paid in advance. Landlord reserves the right, however, to
elect to demolish, rebuild or reconstruct the Building if any portion of the Building
is so taken, and if Landlord so elects, whether or not the Premises are involved in
the taking, this Lease may be terminated by Landlord on written notice to Tenant and
the rent will be adjusted to the date Tenant’s possession of the Premises is terminated. If a
portion of the Premises, Building or Common Area is taken and such taking will, in Tenant’s
reasonable judgment, prevent Tenant from conducting its business in the Premises in a manner
reasonably comparable to that conducted immediately prior to such taking, Tenant shall have
the right to terminate this Lease by giving written notice to Landlord within forty-five (45)
days from the date of such taking. If a portion of the Premises is taken and neither Landlord
nor Tenant terminates this Lease, rent shall abate in proportion that the untenantable portion
of the Premises bears to the entire Premises.

	16.02	 	Condemnation Award: The whole of any award or compensation for any portion of the
Premises taken, condemned or conveyed in lieu of taking or condemnation shall be solely the
property of and payable to Landlord. Nothing herein contained shall be deemed to preclude
Tenant from seeking at its own cost and expense, an award from the condemning authority for
loss of its business, the value of any trade fixtures or other personal property of Tenant in
the Premises or moving expenses, provided that the award for such claim or claims shall not be
in diminution of the award made to Landlord.

10

 

SECTION 17

Assignment or Subletting

	17.01	 	Assignment or Subletting: Tenant agrees not to assign or in any manner transfer
this Lease or any interest in this Lease without the previous written consent of Landlord, and
not to sublet the Premises or any part of the Premises or allow anyone to use or to come in,
with, through or under it without like consent, which consent shall not be unreasonably
withheld or delayed. Upon any attempted unconsented assignment or sublease, Landlord shall
have the right to terminate this Lease. One such consent will not be deemed a consent to any
subsequent assignment, subletting, occupation or use by any other person. Any sublease on the
Premises executed by Tenant and a third party must terminate when the Term of this Lease
expires. The acceptance of rent from an assignee, subtenant or occupant will not constitute a
release of Tenant from the further performance of the obligations of Tenant contained in this
Lease. In the event of any such assignment or sublease of all or any portion of the Premises
where the rental or other consideration reserved in the sublease or by the assignment exceeds
the rental or prorata portion of the rental, as the case may be, for such space reserved in
this Lease, Tenant agrees to pay Landlord monthly, as additional rental, on the Rent Day, the
excess of the rental or other consideration reserved in the sublease or assignment over the
rental reserved in this Lease applicable to the subleased/assigned space. Notwithstanding the
foregoing, Tenant shall have the right to assign this Lease or to sublease all or a portion of
the Leased Premises without Landlord’s consent to (i) an entity resulting from a merger or
consolidation with Tenant; (ii) any entity succeeding to all or substantially all of the
business and assets of Tenant; or (iii) any direct subsidiary of Tenant. When Landlord’s
consent to a sublease is required, Landlord shall, within fifteen (15) business days after
Tenant submits to Landlord a written request for Landlord’s consent to a sublease, which
request shall identify the proposed subtenant and generally describe the nature of such
subtenant’s business and clientele and be accompanied by a copy of the proposed sublease, give
Tenant written notice approving or disapproving of such sublease. If Landlord fails to give
Tenant written notice either approving or disapproving of such proposed sublease within such
fifteen (15) business day period, Landlord shall be deemed to have approved such sublease.
Notwithstanding any of the foregoing, it is clearly understood that any type of embryonic
research or associated activities would not be an approved use in or on the Premises.

SECTION 18

Inspection and Alteration of Public Portions

	18.01	 	Inspection: Tenant agrees, upon reasonable prior written or telephonic notice, to
permit Landlord and the authorized representatives of Landlord to enter the Premises during
Tenant’s normal business hours for the purpose of inspecting

11

 

	 	 	the same. Notwithstanding the foregoing, Landlord shall have the right to access the
Premises without notice to Tenant in the event of an emergency. “Emergency” as used herein
shall mean the threat of immediate injury or damage to persons or property or the immediate
imposition of a civil or criminal fine or penalty.
	 
	18.02	 	Right to Enter and Alter Premises: Upon reasonable prior written or telephonic
notice from Landlord, Tenant shall permit Landlord to erect, use and maintain pipes and
conduits located above the ceiling or below the flooring of the Premises. Landlord or its
agents or designees shall have the right, subject to the provisions of Section 18.01 above, to
enter the Premises, for the purpose of making such repairs or alterations as Landlord shall be
required or shall have the right to make by the provisions of this Lease and, subject to the
foregoing, shall also have the right to enter the Premises for the purpose of exhibiting them
to prospective purchasers of the Building or to prospective mortgagees or to prospective
assignees of any such mortgagees. Landlord shall be allowed to take all material into and
upon the Premises that may be required for the repairs or alterations above mentioned without
the same constituting an eviction of Tenant in whole or in part, and the rent reserved shall
in no wise abate, except as otherwise provided in this Lease, while said repairs or
alterations are being made. Landlord shall at all times have and retain a key with which to
unlock all of the doors in, on or about the Premises (excluding Tenant’s vaults, safes and
similar areas designated in writing by Tenant in advance ); and Landlord shall have the right
to use any and all means which Landlord may deem proper to open said doors in an emergency in
order to obtain entry to the Premises, and any entry to the Premises obtained by Landlord by
any of said means, or otherwise, shall not under any circumstances be construed or deemed to
be a forcible or unlawful entry into or a detainer of the Premises or an eviction, actual or
constructive, of Tenant from the Premises, or any portion thereof. Notwithstanding anything
contained herein to the contrary, Landlord covenants and agrees that any such entry shall be
conducted so as to minimize interference with Tenant’s business operations.
	 
	18.03	 	Right to Show Premises: During the twelve (12) months prior to the expiration of
the Term of this Lease, Landlord may exhibit the Premises to prospective tenants upon prior
reasonable written or telephonic notice during Tenant’s normal business hours.
	 
	18.04	 	Right to Alter Public Portions of Building: Landlord shall have the right at any
time without thereby creating an actual or constructive eviction or incurring any liability to
Tenant therefore, to change the arrangement or location of entrances, passageways, doors, and
doorways, corridors, stairs, toilets and other like public service portions of the Building;
provided such modifications do not materially and adversely affect Tenant’s use of the
Premises. Tenant shall at all times be provided with safe and convenient entrance to the
Premises.

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	18.05	 	Name of Building: Landlord shall have the right at any time to name the Building
for any person(s) or tenant(s) and to change any and all such names at any time thereafter.

SECTION 19

Fixtures and Equipment

	19.01	 	Landlord’s Property: All fixtures and equipment paid for by Landlord and all
improvements, fixtures and equipment which may be paid for and placed on the
Premises by Tenant from time to time but which are so incorporated and affixed to the Premises
that their removal would involve damage or structural change to the Premises, will be and
remain the property of Landlord. Notwithstanding the foregoing, Tenant shall have the
unconditional right to remove all or portions of its trade fixtures and equipment, subject to
Tenant’s obligation as described above to promptly repair any resulting damage, at Tenant’s
sole expense.
	 
	19.02	 	Tenant’s Property: All improvements, furnishings, equipment and fixtures other than
those specified in Subsection 19.01, which are paid for and placed on the Premises by Tenant
from time to time will remain the property of Tenant and be removed by Tenant at the
expiration of the Lease.

SECTION 20

Notices or Demands

	20.01	 	Notices or Demands: All bills, notices, statements, communications or demands
(collectively, “notices or demands”) upon Landlord or Tenant desired or required to be given
under any of the provisions hereof must be in writing. Any such notices or demands from
Landlord to Tenant will be deemed to have been duly and sufficiently given if a copy thereof
has been personally delivered or mailed by United States mail in an envelope properly stamped
and addressed to Tenant at the address of the Premises or at such other address as Tenant may
have last furnished in writing to Landlord for such purpose. Any such notices or demands from
Tenant to Landlord will be deemed to have been duly and sufficiently given if personally
delivered to Landlord or mailed by United States mail in an envelope properly stamped and
addressed to Landlord at the address set forth in the Lease Summary or such other address as
the Landlord may designate in writing from time to time. The effective date of such notice or
demand will be deemed to be the time when personally delivered or mailed as herein provided.

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SECTION 21

Breach; Insolvency; Re-Entry

	21.01	 	Default: If any rental payable by Tenant to Landlord remains unpaid for more than
ten (10) days after written notice to Tenant of nonpayment, or if Tenant violates or defaults
in the performance of any of its obligations in this Lease and the violation or default
continues for a period of thirty (30) days after written notice (unless more than thirty (30)
days is reasonably required to cure the breach and Tenant commences with that 30-day period to
cure the breach and diligently prosecutes the cure to completion), then Landlord may (but will
not be required to) declare this Lease forfeited and the Term ended, or re-enter the Premises,
or may exercise all other remedies available under Michigan law. Landlord will not be liable
for damages to person or property by reason of any legitimate re-entry or forfeiture.
	 
	21.02	 	Bankruptcy: If Tenant is adjudged bankrupt or insolvent, files or consents to the
filing of a petition in bankruptcy under Federal or State law, applies for or consents to the
appointment of a receiver for all or substantially all of its assets, or makes a general
assignment for the benefit of its creditors, then Tenant shall be in default under this Lease
and, to the extent from time to time permitted by applicable law, including but not limited to
the Federal Bankruptcy Code, Landlord shall be entitled to exercise all remedies set forth in
Section 21.01. In a reorganization under Chapter 11 of the Federal Bankruptcy Code, the
debtor or trustee must assume this Lease or assign it within sixty (60) days from the filing
of the proceeding, or he shall be deemed to have rejected and terminated this Lease. Tenant
acknowledges that its selection to be the tenant hereunder was premised in material part on
Landlord’s determination of Tenant’s creditworthiness and the character of its occupancy and
use of the Premises would be compatible with the nature of the Premises and other adjacent
properties and tenants of Landlord. Therefore, if Tenant, as debtor, or its trustee
elects to assume this Lease, in addition to complying with all other requirements for
assumption under the Federal Bankruptcy Code, then Tenant, as debtor, or its trustee or
assignee, as the case may be, must also provide the adequate assurance of future performance,
including but not limited to a deposit, the amount of which shall be reasonably determined
based on the duration of time remaining in the Term, the physical condition of the Premises at
the time the proceeding was filed, and such damages as may be reasonably anticipated after
reinstatement of the Lease.
	 
	21.03	 	Re-Leasing of Premises: In the event of declaration of forfeiture at or after the
time of re-entry, and after all required notice and cure periods have expired without a cure
or commencement of a cure, Landlord may re-lease the Premises or any portion(s) of the
Premises for a term or terms and at a rent which may be less than or exceed the balance of the
term of and the rent reserved under this Lease. In such event Tenant will pay Landlord as
liquidated damages for

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	 	 	Tenant’s default any deficiency between the total rent reserved and the net amount, if any,
of the rents collected on account of the lease or leases of the Premises which otherwise
would have constituted the balance of the term of this Lease. In computing such liquidated
damages, there will be added to the deficiency reasonable expenses which Landlord may incur
in connection with re-leasing, such as legal expenses, reasonable attorneys’ fees, brokerage
fees and expenses, advertising and for keeping the Premises in good order or for preparing
the Premises for re-leasing. Any such liquidated damages will be paid in monthly
installments by Tenant on the Rent Day and any such suit brought to collect the deficiency
for any month will not prejudice Landlord’s right to collect the deficiency for any
subsequent month by a similar proceeding. In lieu of the foregoing computation of
liquidated damages, Landlord may elect, at its sole option, to receive liquidated damages in
one payment equal to any deficiency between the total rent reserved hereunder and the fair
and reasonable rental of the Premises, both discounted at five percent (5%) per annum to
present value at the time of declaration of forfeiture.
	 
	21.04	 	Failure to Re-Lease Premises: Whether or not forfeiture has been declared,
Landlord will attempt to re-lease the Premises, however, Landlord will not be
responsible in any way for failure to re-lease the Premises, or in the event that the Premises
are re-leased, for failure to collect the rent under such re-leasing. The failure of Landlord
to re-lease all or any part of the Premises will not release or affect Tenant’s liability for
rent or damages.
	 
	21.05	 	Mitigation of Damages. Notwithstanding anything contained herein to the contrary,
Landlord shall only recover once for its damages as provided herein. Landlord shall exercise
its rights and remedies in a commercially reasonable manner so as to mitigate its damages. If
Landlord recovers a money judgment against Tenant for Tenant’s default of its obligations
hereunder or otherwise, the judgment shall be limited to Landlord’s actual direct, but not
consequential damages or lost profits.

SECTION 22

Surrender of Premises on Termination

	22.01	 	Condition of Premises Upon Termination: At the expiration (or earlier termination)
of the Term, Tenant will surrender the Premises broom clean and in as good condition and
repair as they were at the time Tenant took possession, reasonable wear and tear excepted, and
promptly upon surrender will deliver all keys and building security cards for the Premises to
Landlord at the place then fixed for payment of rent. All reasonable costs and expenses
incurred by Landlord in connection with repairing or restoring the Premises to the condition
called for herein, together with the costs, if any, of removing from the Premises any property
of Tenant left therein shall be invoiced to Tenant and shall be payable as additional rental
within thirty (30) days of the date of such invoice.

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	22.02	 	Storage of Tenant’s Property: If Tenant fails to remove all its property (or
property of others in its possession) from the Premises on termination of this Lease (for any
cause), Landlord at its option may remove the property in any manner that it chooses and may
store the property without liability to Tenant for loss, whether based on contract, tort or
otherwise. Tenant agrees to pay Landlord on demand any and all expenses incurred in such
removal, including court costs, reasonable attorneys’ fees and storage charges on the property
for any length of time it is in Landlord’s possession. Tenant will indemnify and hold
Landlord harmless from any claim by third parties with respect to property owned or claimed by
them, left in the Premises by Tenant, and removed by Landlord pursuant to this paragraph.
Under no circumstances will Landlord be obligated to retain any property left on the Premises
or in Landlord’s possession longer than two (2) months after termination of this Lease (for
any cause) and Landlord may after two (2) months dispose of the property in any manner it
deems appropriate, including public or private sale or by destruction, discard or
abandonment and the proceeds of any such sale will be applied against any sums due Landlord
under this Lease.

SECTION 23

Performance by Landlord of the Covenants of Tenant

	23.01	 	Tenant’s Failure to Perform: If Tenant fails to pay any sum of money, other than
rental, required to be paid hereunder or fails to perform any act on its part to be performed
hereunder and such failure shall continue for a period of thirty (30) days after written
notice from Landlord (or a reasonable period of less than thirty (30) days when life, person
or property is in jeopardy), Landlord may (but shall not be required to) after all required
notice and cure time periods have expired without a cure or commencement of a cure, and
without waiving or releasing Tenant from any of Tenant’s obligations, make any such payment or
perform any such other act. All sums paid by Landlord and all reasonable incidental costs,
including without limitation the cost of repair, maintenance or restoration of the Premises if
so performed by Landlord hereunder, shall be deemed additional rental and, together with
interest thereon at the rate set forth in Section 5.02 from the date of payment by Landlord
until the date of repayment by Tenant to Landlord, shall be payable to Landlord within thirty
(30) days after receipt of invoice by Tenant. Notwithstanding the foregoing, if any such
failure cannot reasonably be remedied within thirty (30) days after notice of such failure,
then Tenant shall have such additional time (not to exceed an additional thirty (30) days) as
shall be reasonably necessary to remedy such failure (so long as Tenant continues to use due
diligence) before Landlord can perform obligations On default in such payment, Landlord shall
have the same remedies as on default in payment of rent. The rights and remedies granted to
Landlord under this Section 23 shall be in addition to and not in lieu of all other remedies,
if any, available to Landlord under this Lease or otherwise, and nothing herein contained
shall be

16

 

	 	 	construed to limit such other remedies of Landlord with respect to any matters covered
herein.

SECTION 24

Subordination; Estoppel Certificates

	24.01	 	Subordination: Tenant agrees, that at Landlord’s option, this Lease may be either
subordinate or paramount to any construction loans, mortgages, trust deeds and ground or
underlying leases now or hereafter affecting the Premises and to any and all advances to be
made thereunder, and to the interest and charge thereon, and all renewals, replacements and
extensions thereon, provided the mortgagee, lessor or trustee named in any such mortgages,
trust deeds or leases agrees to recognize the lease of Tenant in the event of foreclosure or
other enforcement of such instruments (and, if requested by Tenant, shall enter into a
commercially reasonable non-disturbance agreement with Tenant) if Tenant is not in default.
This section shall be self-operative and no further instrument shall be required. However,
Tenant will execute promptly any instrument or certificate that Landlord may reasonably
request to confirm such subordination or superior status, subject to Tenant’s receipt of a
non-disturbance agreement, if so requested.

SECTION 25

Substitute Space

	25.01	 	Substitute Space: Intentionally deleted.

SECTION 26

Quiet Enjoyment

	26.01	 	Quiet Enjoyment: Landlord agrees that at all times when Tenant is not in default
under the provisions and during the Term of this Lease, Tenant’s quiet and peaceable enjoyment
of the Premises will not be disturbed or interfered with by Landlord or any person claiming
by, through, or under Landlord.

SECTION 27

Holding Over

	27.01	 	Holding Over: If Tenant remains in possession of the Premises after expiration of
this Lease without executing a new lease, it will be deemed to be occupying the Premises as a
tenant from month-to-month (regardless of whether rent is reserved annually or monthly
hereunder), subject to all the provisions of this Lease to the extent that they can be
applicable to a month-to-month tenancy,

17

 

	 	 	except that the minimum rental for each month will be one hundred twenty percent (120%) of
the Base Monthly Rental.

SECTION 28

Remedies Not Exclusive; Waiver

	28.01	 	Remedies: Each and every of the rights, remedies and benefits provided by this
Lease are cumulative and are not exclusive of any other of said rights, remedies and benefits,
or of any other rights, remedies and benefits allowed by law.
	 
	28.02	 	Waiver of Covenant: One or more waivers of any covenant or condition by Landlord
will not be construed as a waiver of a further or subsequent breach of the same covenant or
condition, and the consent or approval by Landlord to or of any act by Tenant requiring
Landlord’s consent or approval will not be deemed to waive or render unnecessary Landlord’s
consent to or approval of any subsequent similar act by Tenant.

SECTION 29

Waiver of Subrogation

	29.01	 	Waiver of Subrogation: Landlord and Tenant shall obtain permission from each
insurer to, and to the extent so permitted, hereby waive any and all right of recovery against
each other for any loss or damage caused by fire or any of the risks covered by standard fire
and extended coverage, vandalism and malicious mischief insurance policies.

SECTION 30

Indemnification

	30.01	 	Indemnification by Tenant: Tenant at its expense will defend, indemnify and save
Landlord and its licensees, servants, agents, employees and contractors, harmless from any
claim or condition of the Premises, the use or misuse thereof by Tenant or any other person,
the acts or omissions of Tenant, its clients, customers, invitees, licensees, servants,
agents, employees or contractors, the failure of Tenant to comply with any provision of this
Lease, or any other event occurring on the Premises, whatever the cause; provided, however,
that nothing herein shall be construed to require Tenant to indemnify Landlord or its
licensees, servants, agents, employees, and contractors against Landlord’s or its licensees’,
servants’, agents’, employees’ and contractors’ own acts, omissions or neglect.
	 
	30.02	 	Indemnification by Landlord: Landlord at its expense will defend, indemnify and
save Landlord and its licensees, servants, agents, employees and

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	 	 	contractors, harmless from any claim or condition of the Premises, the use or misuse thereof
by Tenant or any other person, the acts or omissions of Tenant, its clients, customers,
invitees, licensees, servants, agents, employees or contractors, the failure of Landlord to
comply with any provision of this Lease, or any other event occurring in the Building or
Common Areas, whatever the cause; provided, however, that nothing herein shall be construed
to require Landlord to indemnify Tenant or its licensees, servants, agents, employees, and
contractors against Tenant’s or its licensees’, servants’, agents’, employees’ and
contractors’ own acts, omissions or neglect.

SECTION 31

Assignment by Landlord

	31.01	 	Assignment by Landlord: The term “Landlord” as used in this Lease so far as
covenants, agreements, stipulations or obligations on the part of the Landlord are
concerned is limited to mean and include only the owner or owners of fee title (or of a ground
leasehold interest or land contract vendee’s interest) to the Premises at the time in
question, and in the event of any transfer or transfers of the title to such fee the Landlord
herein named (and in case of any subsequent transfers or conveyances the then grantor) will
automatically be freed and relieved from and after the date of such transfer or conveyance of
all liability for the performance of any covenants or obligations on the part of the Landlord
contained in this Lease thereafter to be performed.
	 
	31.02	 	Landlord’s Default: If Landlord fails to perform any provision of this Lease upon
Landlord’s part to be performed, and if as a consequence of such default Tenant recovers a
money judgment against Landlord, such judgment may be satisfied only out of the proceeds of
sale received upon execution of such judgment and levied thereon against the right, title and
interest of Landlord in the Premises and out of rents or other income from such property
receivable by Landlord and Landlord shall not be personally liable for any deficiency.

SECTION 32

Security Deposit

	32.01	 	Security Deposit: Landlord hereby acknowledges the receipt of the Security Deposit,
if any. If Tenant defaults in any of the provisions of this Lease, Landlord may use, apply or
retain all or any part of the Security Deposit for the payment of rents and/or other charges
which are the obligation of Tenant under this Lease in default or for any other sum which
Landlord may expend by reasons of Tenant’s default, including any damages or deficiency in the
releasing of the Premises. If Tenant fully complies with all the provisions of this Lease,
the Security Deposit, or balance thereof, will be returned to Tenant without interest after
(i) the termination of this Lease, (ii) the removal of Tenant, and (iii) the surrender of

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	 	 	possession of the Premises to Landlord. Unless Landlord is shown evidence satisfactory to
it that the right to receive the Security Deposit has been assigned, Landlord may return the
Security Deposit to the original Tenant regardless of one or more assignments of the Lease
itself.

SECTION 33

Hazardous Materials

	33.01	 	No Hazardous Materials: Tenant warrants and represents that the Premises will not
be used by Tenant, or anyone acting by or through Tenant to dispose of, refine, generate,
manufacture, produce, store, handle, treat, transfer, release, process or transport any
Hazardous Materials in violation of any applicable laws, rules or regulations.
	 
	33.02	 	Use of Premises: Tenant shall not cause or permit the Premises to be used to
generate, manufacture, refine, transport, treat, store, handle, dispose of, transfer,
produce or process Hazardous Materials in violation of any applicable laws, rules or
regulations, nor shall Tenant cause or permit, as a result of any intentional or unintentional
act or omission on the part of Tenant, a release of Hazardous Materials onto the Premises.
Tenant agrees to promptly deliver to the Landlord copies of all notices received by Tenant
from any federal, state or local authority regarding environmental problems affecting the
Premises. The provisions hereof shall be in addition to any and all other obligations and
liabilities Tenant may have to the Landlord in common law and shall survive termination of
this Lease and the satisfaction of all other obligations of Tenant hereunder.
	 
	33.03	 	Presence of Hazardous Materials/Indemnity: If Hazardous Materials are present on or
under the Premises as a result of the acts or omissions of Tenant, Tenant shall: (1) conduct
and complete all investigations, studies, sampling and testing, and all remedial, removal and
other actions necessary to clean up and remove all Hazardous Materials on, under, from or
affecting the Premises in accordance with all applicable Environmental Law; (ii) defend,
indemnify and hold harmless Landlord, its employees, agents, officers and directors from and
against any claims, demands, penalties, fines, liabilities, settlements, damages, costs or
expenses of whatever kind or nature, known or unknown, contingent or otherwise, arising out of
or in any way related to: (A) the presence, disposal, release or threatened release of any
Hazardous Materials on, over, under, from or affecting the Premises or the soil, water,
vegetation, buildings, personal property, persons or animals thereon; (B) any personal injury
(including wrongful death) or property damage (real or personal) arising out of or related to
such Hazardous Materials; (C) any lawsuit brought or threatened, settlement reached or
government order relating to such Hazardous Materials; or (D) any violation of laws, orders,
regulations, requirements or demands of government authorities, or any policies or
requirements of Landlord, which are based upon or in any way
related to such Hazardous Materials, including, without limitation, reasonable

20

 

	 	 	attorney’s and consultant’s fees, investigation and laboratory fees, court costs and litigation
expenses. In no event shall Tenant have any liability for: (i) any act of negligence of
the Landlord or its successors or assigns, (ii) conditions not in existence on the day
Landlord, its successors or assigns, takes possession of the Premises; (iii) conditions
caused by, aggravated or worsened by Landlord, or its successors, assigns or any third
party, after the date Landlord or its successors and assigns takes such possession; or (iv)
conditions caused or permitted by Landlord, any previous or current tenant of the Building,
any previous owner or previous owners’ tenants, or anyone other than Tenant its affiliates,
agents, contractors, vendors or invitees. In any event, provided enforcement is stayed,
there shall be no liability with respect to a Hazardous Materials “clean up” until Tenant’s
rights to appeal any governmental order (state or federal) relating to a “clean up” shall
have been exhausted, waived, or terminated.

SECTION 34

Movement of Tenant’s Property

	34.01	 	Moving Tenant’s Property: All activities of Tenant in connection with (a) Tenant’s
move into the Premises at the commencement of this Lease, (b) the movement of equipment,
furniture or other bulky items into, out of or within the Premises during the Term, or (c)
Tenant’s move out of the Premises at any time (whether or not on the termination of this
Lease) will be subject to the following:

	 	A.	 	Designated Access: All furniture, equipment and all other items of
personal property being moved or transferred will enter and leave the
Building solely through and by way of such area or entrance as may be
designated from time to time by Landlord for such purposes;
	 
	 	B.	 	Tenant Responsible: Tenant will be responsible for the active
supervision (on-site) of all workmen and others performing the move, and
will indemnify and hold harmless Landlord against and from all liability
for damage to property (whether belonging to Landlord, other tenants or
any other person) and injuries to persons in connection with the move
and the actions, or failure to act, of or by those performing the move;
provided, however, that nothing herein shall be construed to require Tenant to
indemnify Landlord or its licensees, servants, agents, employees, and contractors
against Landlord’s or its licensees’, servants’, agents’, employees’ and contractors’
own acts, omissions or neglect.
	 
	 	C.	 	Damage: Tenant will be responsible for any damage to the Building, the
Common Areas, the Premises, or the premises and property of other tenants, caused by or
incurred in connection with the move or the activities connected therewith. Landlord
will perform such inspection(s) as Landlord in its sole discretion determines to be appropriate, and will invoice Tenant for the 

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	 	 	 	reasonable costs
of repair of all such damage or the replacement, if necessary, of damaged items. All
determinations of the extent of damage and the costs of repair or replacement will be
made by Landlord in the exercise of its reasonable, good faith discretion. The invoiced
sums will constitute amounts included within and payable under Section 9, above.

SECTION 35

Non-Terminability, Compliance With Laws, Costs, Severability

	35.01	 	Intentionally deleted.

SECTION 36

Entire Agreement

	36.01	 	Entire Agreement: This Lease and the Riders attached hereto which are hereby
incorporated herein and form a part hereof, set forth all of the covenants, agreements,
stipulations, promises, conditions and understandings between Landlord and Tenant concerning
the Premises and there are no covenants, agreements, stipulations, promises, conditions or
understandings, either oral or written, between them concerning the Premises other than herein
set forth.

SECTION 37

Recording

	37.01	 	Recording: This Lease shall not be recorded by Tenant nor shall Tenant file or
record a memorandum of lease or affidavit of claim with respect to this Lease or the Premises.
At Landlord’s option, Landlord may record this Lease. Upon Landlord’s request, Tenant shall
execute and deliver to Landlord a memorandum of lease or affidavit of claim for recording by
Landlord.

SECTION 38

General

	38.01	 	General Terms: Many references in this Lease to persons, entities and items have
been generalized for ease of reading. Therefore, reference to a single person, entity or item
will also mean more than one person, entity or thing whenever such usage is appropriate.
Similarly, pronouns of any gender should be considered interchangeable with pronouns of other
genders.
	 
	38.02	 	Joint and Several: In the event more than one party signs this Lease as Tenant such
parties shall be both jointly and severally liable for payment of amounts due hereunder and performance of the terms and conditions hereof. This Lease may 

22

 

	 	 	be enforced by Landlord against any of such parties at Landlord’s sole discretion. Each Tenant consents to
the in personam jurisdiction of the Michigan Courts located in Washtenaw County, Michigan
and the United States Federal Court for the Eastern District of Michigan.
	 
	38.03	 	Captions: Captions to sections and paragraphs are provided solely for the sake of
convenience and shall have no substantive effect whatsoever.
	 
	38.04	 	Amendments: This lease can be modified or amended only by a written agreement
signed by Landlord and Tenant.
	 
	38.05	 	Binding Lease: All provisions of this Lease are and will be binding on the heirs,
executors, administrators, personal representatives, successors and assigns of Landlord and
Tenant.
	 
	38.06	 	Governing Law: The laws of the State of Michigan will control in the construction
and enforcement of this Lease.
	 
	38.07	 	Signage: Landlord shall, at its sole cost and expense, provide building standard
signage identifying Tenant and the Premises.
	 
	38.08	 	Brokers: Each party represents and warrants that they have not dealt with any
person who would be entitled to broker’s fees or commissions in connection with the
transactions contemplated by this Lease. Each party shall indemnify and hold the other party
harmless from any and all claims for broker’s fees or commissions payable as a result of such
party’s actions.
	 
	38.09	 	Unavoidable Delays: If either party shall be prevented or delayed from punctually
performing any obligation or satisfying any condition under this Lease by any strike, lockout,
labor dispute, inability to obtain labor or materials or reasonable substitutes therefor, Act
of God, governmental restriction, regulation or control, enemy or hostile governmental action,
civil commotion, insurrection, sabotage, fire or other casualty, or any other condition beyond
the reasonable control of such party, then the time to perform such obligation or satisfy such
condition shall be extended by the delay caused by such event. If either party shall, as a
result of any such event, be unable to exercise any right or option within any time limit
provided therefor in this Lease, such time limit shall be deemed extended for a period equal
to the duration of the delay caused by such event.

[END OF TEXT; SIGNATURES FOLLOW ON NEXT PAGE]

23

 

IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the day and year first above
written.

	 	 	 	 	 	 	 	 	 	 	 
	WITNESS:	 	 	 	LANDLORD:	 	 
	 	 	 	 	DOMINO’S FARMS OFFICE PARK, L.L.C.	 	 
	 	 	 	 	(a Michigan limited liability company)	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	/s/ Margaret Parkinson	 	 	 	By:	 	/s/ Paul R. Roney	 	 
	 

	 	 	 	 	 	Its:
	 	Manager	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	TENANT:	 	 
	 	 	 	 	AASTROM BIOSCIENCES, INC.	 	 
	 	 	 	 	(a Michigan Corporation)	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	/s/ Margaret Parkinson	 	 	 	By:	 	/s/ Gerald D. Brennan, Jr.	 	 
	 

	 	 	 	 	 	Its:
	 	VP, Administrative & Financial
Operations and CFO	 	 

24

 

RIDER A

Location of Premises

The office is located in the building commonly known as Domino’s Farms Prairie House located at 24
Frank Lloyd Wright Drive, Lobby K, Ann Arbor, Michigan 48106.

25

 

RIDER B

Rules and Regulations

     The Landlord, or the Agent of the Landlord, as the case may be, reserves the right to make
such other further and reasonable rules and regulations as in its judgment may from time to time be
necessary or desirable for the safety and preservation of good order and prestige therein.

     Wherever the word “Tenant” occurs, it is understood and agreed that it shall mean Tenant’s
employees, agents, clerks, servants and visitors. Wherever the word “Landlord” occurs, it is
understood and agreed that it shall mean Landlord’s assigns, agents, clerks, servants and visitors.

	1.	 	No sign, picture, lettering, notice or advertisement of any kind shall be painted,
taped or displayed on or from the windows, doors, roof or outside wall of the
premises. Landlord shall have the right to approve all signs, exhibits and displays to be
made by Tenant in and from common areas of the building. All of Tenant’s interior sign
painting or lettering shall be approved by Landlord and the cost thereof shall be paid by
Tenant.
	 
	2.	 	No electric or other wires for any purpose shall be brought into the premises without
Landlord’s written permission specifying the manner in which same may be done. This shall
prohibit use of hot plates (cooking) and only approved electric percolators or coffee makers
shall be permitted. No boring, cutting or stringing of wire shall be done without Landlord’s
prior written consent. Tenant shall not disturb or in any way interfere with the electric
light fixtures, and all work upon or alterations to the same shall be done by persons
authorized by Landlord.
	 
	3.	 	Water closets and other toilet fixtures shall not be used for any purpose other than that for
which the same is intended, and any damage resulting to same from Tenant’s misuse shall be
paid for by Tenant. No person shall waste water by interfering or tampering with the faucets
or otherwise.
	 
	4.	 	No person shall disturb the occupants of this or adjoining buildings or premises by the use
of radios, television sets, loud speakers, or musical instruments, or by making loud or
disturbing noises.
	 
	5.	 	No bicycle or other vehicle and no pets shall be allowed in offices, hall, corridors or
elsewhere in the building.
	 
	6.	 	No floor load exceeding an average rate of 60 pounds of live load per square foot of floor
area can be allowed. Tenant’s business machines and mechanical equipment which cause
vibration or noise that may be transmitted to the building structure or to any other leased
space in the building shall be placed and

26

 

	 	 	maintained by Tenant in settings of cork, rubber, spring or other types of vibration
eliminators sufficient to eliminate such vibration or noise.
	 
	7.	 	Any safe, vault, heavy equipment, furniture, or machinery moved in or out of the
premises shall be moved in such manner and at such times as Landlord shall in each instance
approve.
	 
	8.	 	No additional lock or locks shall be placed on any door in the building without
Landlord’s prior written consent. Upon the termination of this Lease, the Tenant
shall surrender to Landlord all keys and card access to the premises. A twenty-five dollar
fine will be imposed for each key or card access not returned to Landlord.
	 
	9.	 	Tenant shall not install or operate any steam or gas engine or boiler, or carry on any
mechanical business on said premises, or use oil burning fluids or gasoline for heating or
lighting or for any other purpose. No article deemed extra hazardous on account of fire or
other dangerous properties, or any explosive, shall be brought into said premises.
	 
	10.	 	The premises shall not be used for lodging or sleeping, or for any immoral or illegal
purposes.
	 
	11.	 	Any newspaper, magazine or other advertising done from the said premises or
referring to the said premises, Domino’s Farms or Prairie House, which in the opinion
of the Landlord is objectionable, shall be immediately discontinued upon notice from
the Landlord.
	 
	12.	 	The sidewalk, entry, passage hall and stairway shall not be obstructed or used for any
purpose other than those of ingress and egress without the express written consent of the
Landlord.
	 
	13.	 	All deliveries to the premises shall be through the loading docks, and at no time shall
delivery companies block the parking lots, fire lanes or facility entrances with delivery
vehicles.
	 
	14.	 	Window coverings other than those which may be provided by Landlord, either inside or outside
of the windows, may only be installed with the Landlord’s prior written consent, and must be
furnished, installed and maintained at the expense of the Tenant and at Tenant’s risk, and
must be of such shape, color, material, quality and design as may be prescribed by the
Landlord. Tenant shall exercise reasonable care in placing furniture, equipment, etc. in such
a position as to not obstruct the windows.
	 
	15.	 	Tenant will exercise reasonable discretion with regard to thermostat settings within the
tenant space. Acceptable temperatures for heating will not exceed 72 degrees or fall below 68
degrees for cooling.

27

 

	16.	 	Tenant will be responsible for vending service located within the tenant premises. Landlord
will designate approved vending contractors within the building. Tenant will coordinate
vending installation with Landlord.
	 
	17.	 	Domino’s Farms is a smoke free campus; smoking of cigars, pipes and cigarettes are not
allowed inside the facility, near any entrances to the building, in the parking lots or on the
property.
	 
	18.	 	Subject to the terms of the Lease between Tenant and Landlord, Landlord will provide normal
heating, ventilation and air conditioning as reasonably required by prevailing weather
conditions to the leased premises on the following days (except legal holidays):

	 	 	 
	Monday — Friday

	 	8:00 AM to 8:00 PM
	Saturday

	 	8:00 AM to 2:00 PM

	 	 	Should the Tenant require occasional HVAC operation outside the hours stated above, such
operation will be available at a cost of $25.00 per hour.
	 
	19.	 	Periodic fire drills and emergency evacuation drills (to include severe weather) will be
conducted by the building Security Department. Tenant participation is mandatory.

28

 

RIDER C

Work Agreement

This Work Agreement is attached to and made a part of the Lease by and between Domino’s Farms
Office Park LLC (“Landlord”) and Aastrom Biosciences, Inc. (“Tenant”) for space in the building
located at 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan.

The Work Agreement shall set forth the obligations of Landlord and Tenant with respect to the
improvements to be performed in the Premises for Tenant’s use. All improvements described in this
Work Agreement are hereinafter referred to as the “Leasehold Improvements.”

All changes and improvements to the Premises will be made in accordance with plans and
specifications which will be provided to and approved by Landlord, subject to the Interior
Specifications for Tenant Improvements Manual for this facility. Landlord will not unreasonably
withhold consent for Tenant to make improvements so long as the Leasehold Improvements are
consistent and compatible with materials and colors of the existing building. The Landlord shall
serve as the General Contractor for said Leasehold Improvements, and will not charge Tenant a fee
for said services. The Landlord shall be responsible for obtaining any and all applicable permits,
and to insure that all work is paid for in full, and that Landlord’s interest in the property will
be kept free from any liens.

For the Level 1 Mechanical and Storage Rooms, the Tenant will accept the space in “As-is” condition
and configuration.

For the Level 2 suite, the Landlord will contribute up to $35 per usable square foot (maximum of
$1,040,725) to the cost of the construction and improvements to the Premises.

As of the date of execution of this Lease, a detailed space plan for the Premises is being prepared
for the Tenant by Ann Arbor Architects Collaborative (A3C). Working drawings and specifications
(the “Plans”) are being developed and finalized, and all costs for same will be considered part of
the Leasehold Improvements and shall be paid from the Landlord’s Allowance. The cost for said
architectural services will be documented with actual invoices upon receipt and payment by the
Landlord. The balance of the Landlord’s Allowance will be applied to invoices for work related to
the Leasehold Improvements. The cost of the Leasehold Improvements which exceeds the Landlord’s
Allowance will be the responsibility of the Tenant.

The Landlord is willing to finance up to 67% of the Tenant portion of the construction costs, not
to exceed $900,000, over a 4 year period of time at a seven (7) percent interest rate. This offer
is predicated upon a total construction budget of approximately $2.4 million. After the project
is complete and all invoices have been received and

29

 

compiled, the Landlord’s contribution will be subtracted from the final cost. The remainder, which
will be the Tenant’s portion, will then be divided. The portion that the Landlord is willing to
finance will be amortized and divided over a 48 month payment plan. The monthly amount shall be
due and payable with the rent payments. The balance of the costs will be due and payable by the
Tenant in a lump sum within 30 days of receipt of an invoice for same.

In the event the cost of the Tenant Improvements does not reach or exceed the stated contribution
provided by the Landlord, Tenant shall have no claim to the unallocated funds.

Landlord shall, promptly after approval of the Plans, submit to Tenant a detailed written statement
of the cost of the Leasehold Improvements (the “Estimated Budget”). If the cost of the Leasehold
Improvements set forth in the Estimated Budget is equal to or less than the Landlord’s Allowance,
Landlord shall promptly commence the performance of the Leasehold Improvements. If the cost of the
Leasehold Improvements set forth in the Estimated Budget is more than Landlord’s Allowance, then at
Tenant’s election, to be made by giving written notice to Landlord within seven (7) days after
Tenant’s receipt of the Estimated Budget, either (a) Landlord shall promptly commence performing
the Leasehold Improvements as reflected in the Plans or (b) the Plans shall be revised as
reasonably requested by Tenant so that the cost of the Leasehold Improvements will be acceptable to
Tenant and Landlord shall, after approval of such Tenant, issue a revised Estimated Budget
satisfactory to Tenant. If the revised Estimated Budget still exceeds Landlord’s Allowance, Tenant
may either make further modifications to the Plans or elect to pay any overage by giving written
notice of such election to Landlord within seven (7) days after receipt of the revised Estimated
Budget.

Landlord shall construct the Leasehold Improvements (i) in an expeditious manner, (ii) in
accordance with all applicable laws, including but not limited to the Americans with Disabilities
Act, and the Working Drawings, as the same may be revised from time to time with the approval of
Landlord and Tenant, and the plans and specifications for the Additional Work, if any, approved by
Landlord and Tenant (the “Additional Work Drawings”), (iii) in a good and workmanlike manner, and
(iv) using new materials unless otherwise specified in the Working Drawings or Additional Work
Drawings. Landlord shall, at its sole cost, correct any defects in workmanship or materials in the
Leasehold Improvements which appear within one (1) year after the Commencement Date. Landlord
covenants and agrees that on the Commencement Date, the HVAC, electrical, plumbing, sprinkler and
other utility systems serving the Premises will be in good working order and the Premises shall be
in compliance with all applicable laws and covenants, conditions and restrictions of record.

Landlord shall give Tenant notice not less than thirty (30) days prior to the anticipated date of
Substantial Completion (as defined in the Lease Summary). In addition, Landlord shall grant to
Tenant a license to have access to the Premises and, as reasonably necessary, the Building at least
two (2) weeks prior to the date designated
in the Lease for the commencement of the term of the Lease to allow Tenant to do other

30

 

work required by Tenant to make the Premises ready for Tenant’s use and occupancy (the “Tenant’s
Pre-Occupancy Work”), including but not limited to installing furniture, fixtures and telephone
and data equipment and cabling. In no event shall such access to the Premises or the performance
of Tenant’s Pre-Occupancy Work or any other provision of this Paragraph 8 constitute occupancy of
the Premises by Tenant for purposes of determining when the Work shall be deemed to be
“substantially completed” or determining when the Commencement Date has occurred. It shall be a
condition to the grant by Landlord and continued effectiveness of such license that:

          (i) Tenant shall give to Landlord written notice that it will access the Premises for such
purposes not less than five (5) days prior to the date on which such access will commence, which
written notice shall contain or shall be accompanied by each of the following items, all in form
and substance reasonably acceptable to Landlord: (a) a detailed description of and schedule for
Tenant’s Pre-Occupancy Work; (b) the names and addresses of all contractors, subcontractors and
material suppliers and all other representatives of Tenant who or which will be entering the
Premises on behalf of Tenant to perform Tenant’s Pre-Occupancy Work or will be supplying materials
for such work, and the approximate number of individuals, itemized by trade, who will be present in
the Premises; (c) copies of all plans and specifications pertaining to Tenant’s Pre-Occupancy Work;
(d) copies of all licenses and permits, if any, in connection with the performance of Tenant’s
Pre-Occupancy Work; and (e) certificates of insurance (in amounts reasonably satisfactory to
Landlord and with the parties identified in, or required by, the Lease named as additional
insureds).

          (ii) Such pre-term access by Tenant and its representatives shall be subject to reasonable
scheduling by Landlord provided that such scheduling shall not prohibit access during normal
business hours.

          (iii) Tenant’s employees, agents, contractors, workmen, mechanics, suppliers and invitees
shall work in harmony and not interfere with Landlord or Landlord’s agents in constructing the
Leasehold Improvements, Landlord’s work in other premises and in common areas of the Building, or
the general operation of the Building. If at any time any such person representing Tenant shall
cause or threaten to cause such disharmony or interference, including labor disharmony, and Tenant
fails to immediately institute and maintain such corrective actions as directed by Landlord, then
Landlord may withdraw such license upon twenty-four (24) hours’ prior written notice to Tenant.

          (iv) Any such entry into and occupancy of the Premises by Tenant or any person or entity
working for or on behalf of Tenant shall be deemed to be subject to all of the terms, covenants,
conditions and provisions of the Lease and excluding only the covenant to pay Rent. Landlord shall
not be liable for any injury, loss or damage which may occur to any of Tenant’s Pre-Occupancy Work
made in or about the Premises or to property placed therein prior to the commencement of the term
of the Lease, the same being at Tenant’s sole risk and liability, except any injury, loss or damage
arising out of the gross negligence or willful misconduct of Landlord or any of its agents,
contractors or employees.

31

 

RIDER D

Additional Provisions

The following Additional Provisions are attached to and made a part of the Lease by and between
Domino’s Farms Office Park LLC (“Landlord”) and Aastrom Biosciences, Inc. (“Tenant”) for space
in the building located at 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan.

Confidentiality Agreement:

Tenant agrees that Tenant will maintain the confidentiality of, and not disclose to third persons
or parties, any of the details relating to this Lease except to such other persons or entities to
whom Tenant would disclose such information in the ordinary course of its business.

Right of First Refusal:

So long as Tenant is not in default under the terms of this Lease beyond the applicable cure period
at the time, Tenant is hereby granted a right of first refusal to lease the approximate 12,500
usable square feet of space immediately north of and adjacent to the Premises (the “Expansion
Space”). Landlord shall give Tenant notice that it has received a bona fide offer to lease the
Expansion Space, and Tenant shall then have five (5) business days from its notice of the intent to
lease the space to respond and provide Landlord with written notice of its election to lease the
Expansion Space on the same terms and conditions set forth in this Lease. Notwithstanding the
foregoing, the following terms and conditions shall apply to Tenant’s lease of the Expansion Space:

	(i)	 	The term of the lease of the Expansion Space shall commence on the date Landlord delivers
possession of the Expansion Space to Tenant with any required work thereto substantially
completed, and shall be co-terminus with the balance of the Term, and, if applicable, the
Option Periods.
	 
	(ii)	 	Tenant’s Rent shall be proportionately increased to reflect the rentable square footage of
the Expansion Space at the same rate currently in effect for the Premises.

Except as otherwise set forth above, all of the terms and conditions of this Lease shall apply to
Tenant’s lease of the Expansion Space, and the parties agree to execute and deliver an Amendment to
this Lease reflecting the terms and conditions of this Section within thirty (30) days after Tenant
election to lease the Expansion Space. If Tenant does not exercise its Right of First Refusal with
respect to the Expansion Space within the time period required, landlord may lease the Expansion
Space to the prospective tenant. If leasing of the Expansion Space is not consummated within six
(6) months after Tenant’s election not to exercise its Right of First Refusal, a subsequent lease
of the Expansion space shall be subject to Tenant’s Right of First Refusal as set forth above.

32

 

RIDER E

HAZARDOUS MATERIALS

HAZARDOUS MATERIALS / TENANT OBLIGATIONS

	A.	 	Definitions. As used in this Section, “Environmental Law” and “Hazardous
Materials” shall have the following meanings:

	 	1.	 	“Environmental Law” means any applicable federal, state or
local
government law, rule, ordinance or regulation in effect from time to
time relating to the environment, pollution, toxic substances,
Hazardous Materials or solid and /or toxic waste disposal, including,
without limitation, the following statutes and the regulations
promulgated thereunder:

	 	(a)	 	Michigan Solid Waste Management Act, MCLA Section 299.401
et seq.;
	 
	 	(b)	 	Michigan Hazardous Waste Management Act, MCLA Section
299.501 et seq.;
	 
	 	(c)	 	Federal Resource Conservation and Recovery Act of 1976;
	 
	 	(d)	 	Federal Comprehensive Environmental Response, Compensation and
Liability Act of 1980; and
	 
	 	(e)	 	Federal Superfund Amendments and Reauthorization Act of 1986.

	 	2.	 	“Hazardous Materials” means “Hazardous Waste” or “Hazardous
Substance” as those terms are currently defined in the Resource
Conservation and Recovery Act of 1976, the Comprehensive
Environmental Response, Compensation Liability Act of 1980 and the
Superfund Amendments and Reauthorization Act of 1986.

	B.	 	Use of Premises. Tenant shall not cause or permit the Premises to be used to
generate, manufacture, refine, transport, treat, store, handle, dispose of,
transfer, produce or process Hazardous Materials in violation of any
Environmental Law. At all times Tenant shall use and dispose of Hazardous
Materials in compliance with all applicable Environmental Law and all
requirements and guidelines of the United States Nuclear Regulatory
Commission. Tenant shall not cause or permit, as a result of any intentional
or unintentional act or omission on the part of Tenant, a release of Hazardous
Materials onto the Premises, the Building or any area comprising part of the
Domino’s Farms Office Park in violation of Environmental Law. Landlord and

34

 

	 	 	Tenant will promptly deliver to the other copies of all notices received from any federal,
state or local authority regarding environmental problems affecting the Premises. The
provisions hereof shall be in addition to any and all other obligations and liabilities
Tenant may have to the Landlord at law or in equity regarding Tenant’s violation of
Environmental Law and shall survive termination of this Lease and the satisfaction of all
other obligations of Tenant hereunder.

	C.	 	Presence of Hazardous Materials/Indemnity. If Hazardous Materials are present on or
under the Premises in amounts, concentrations or in a manner in violation of Environmental
Law by reason of the acts or omissions of Tenant or its agents, representatives, contractors,
officers, directors, employees, licensees or invitees, Tenant shall: (i) conduct and complete
all investigations, studies, sampling and testing, and all remedial, removal and other
actions necessary to clean up and remove all such Hazardous Materials on, under, from or
affecting the Premises in accordance with all applicable Environmental Law; (ii) defend,
indemnify and hold harmless Landlord, its employees, agents, officers and directors from and
against any claims, demands, penalties, fines, liabilities, settlements, damages, costs or
expenses (including attorneys’ fees) of whatever kind or nature, known or unknown, contingent
or otherwise, arising out of or in any way related to: (A) the presence, disposal, release or
threatened release of any such Hazardous Materials on over, under, from or affecting the
Premises or the soil, water, vegetation, buildings, personal property, persons or animals on,
in over or under the Premises; (B) any personal injury (including wrongful death) or property
damage (real or personal) arising out of or related to such Hazardous Materials; (C) any
lawsuit brought or threatened, settlement reached or government order relating to such
Hazardous Material; and/or (D) any violations of laws, orders, regulations, requirements or
demands of government authorities, or any reasonable policies or requirements of Landlord
(and in the case Landlord’s requirements of which Tenant was provided prior written notice),
which are based upon or in any way related to such Hazardous Materials, including without
limitation, reasonable attorney’s and reasonable consultant’s fees, investigation and
laboratory fees, court costs and out-of-pocket litigation expenses. In no event shall Tenant
have any liability for: (i) conditions not in existence on the day Landlord, its successors
or assigns, takes possession of the Premises from Tenant, (ii) conditions existing prior to
the date Tenant takes possession of the Premises, or (iii) conditions aggravated or worsened
(but only to the extent so aggravated or worsened) by Landlord, or its successors, assigns or
any third party, after the date Landlord or its successors and assigns takes such possession
of the Premises. Landlord shall give Tenant prompt notice of any claim or information of
which Landlord has knowledge that is likely to give rise to a claim for defense, indemnity or
hold harmless under this Section, and shall permit Tenant’s involvement in the defense of any
such claim as reasonably requested by Tenant. Neither Landlord nor Tenant shall settle or pay
any third

 

 

	 	 	party claim with respect to any claim hereunder, except upon the written approval of both
Landlord and Tenant. The provisions hereof shall be in addition to any and all other
obligations and liabilities Tenant may have to the Landlord at law or in equity and shall
survive termination of this Lease and the satisfaction of all other obligations of Tenant
hereunder.

	D.	 	Right of Inspection. Landlord, its successors and assigns shall have the right
to inspect the Premises at any reasonable time and from time to time upon
not less than two (2) hours advance notice in order to determine whether
Hazardous Materials are being used in violation of Environmental Law and
whether Tenant is in full compliance with the terms of this Section, but
Landlord shall have no obligation to conduct such inspections. All such
inspections, including, without limitation, investigation, studies, sampling and
testing, shall be at Tenant’s expense if the Premises are not in compliance
with this Section otherwise they shall be at Landlord’s expense. Tenant is
authorized to install its own security system for access to the Premises using
so-called security card devices. Tenant shall immediately release any such
security system upon notice from Landlord’s security personnel that an
emergency exists requiring access to the Premises. Inspections by Landlord
under this paragraph shall not unreasonably interfere with the operation of
Tenant’s business and Landlord shall comply with Tenant’s Confidentiality
Requirements (as defined in Section 17.01 of this Lease) and Tenant’s
reasonable requests, provided, however, these provisions are subject to any
actions reasonably necessary to meet or ameliorate any emergency
threatening serious bodily injury or property damage.
	 
	E.	 	Effect on Insurance. Notwithstanding anything in this Section to the contrary,
Tenant shall not use or occupy or permit the Premises to be used or
occupied, nor do or permit anything to be done in or on the Premises, in a
manner which will in any way make void or voidable any insurance customary
for buildings or property similar to the Premises (containing terms and
conditions customary for insuring buildings or property similar to the
Premises) then in force with respect thereto, or which will make it
unreasonably difficult or impossible to obtain fire or other insurance
(containing terms and conditions customary for insuring buildings or property
similar to the Premises) carried by Landlord with respect to the property of
which the Premises is a part. If Tenant’s failure to comply with the provisions
of this Section causes any insurance premium to be higher than it would
otherwise be, Tenant shall reimburse Landlord, as additional rent, for that part
of all insurance premiums thereafter paid by Landlord which have been
changed because of Tenant’s failure.
	 
	F.	 	Reports. At reasonable intervals, and at least annually, Tenant shall provide
to Landlord, at Landlord’s request, a list of all Hazardous Materials at any
time used, stored, placed or brought onto the Premises since the date of the
last report furnished to Landlord with respect to Hazardous Materials. In

 

 

	 	 	addition, Tenant shall provide to Landlord such reasonable documentation as Landlord may
request to review the methods and procedures used by the Tenant in handling and
disposing of any Hazardous Materials. If Landlord determines in its reasonable judgment
that any Hazardous Material as it is being used by Tenant (taking into account the
nature of the Hazardous Material, the manner of its use and the quantities on the
Premises) presents an unreasonable hazard to, or unreasonably endangers the health,
safety or welfare of, the Building’s Tenants, or any of them, Tenant shall, as
appropriate, upon written notice from Landlord cease using any such Hazardous Material
on the Premises and immediately dispose of such Hazardous Material in compliance with
all Environmental Law or appropriately modify its use thereof so as to not render such
use unreasonably hazardous or dangerous. In the event that Tenant disputes Landlord’s
assessment or designation of any prohibited Hazardous Material, the matter shall be
referred to an Environmental Engineer for decision. The decision of such Environmental
Engineer shall be conclusive on the parties (except the extent that such decision is
overridden by any governmental authority enforcing any Environmental Law). The fees of
such Environmental Engineer shall be paid by the unsuccessful party and if both parties
are partially unsuccessful, the Environmental Engineer shall apportion such fees and
expenses between the parties, based on the degree of success of each party.

HAZARDOUS MATERIALS / LANDLORD OBLIGATION

	A.	 	Representations
	 
	 	 	In addition, Landlord represents, warrants and covenants to Tenant that:

	 	1.	 	Landlord has not, and, to Landlord’s knowledge no prior owner of the
Building, tenant or prior tenant, occupant or prior occupant of the Building has,
used or permitted the release of any Hazardous Materials on, from or affecting the
Premises in any manner which violates Environmental Law.
	 
	 	2.	 	Landlord has never received any summons, citation, directive, letter,
notice or other communication, written or oral, regarding any violation of
Environmental Law affecting the Premises, and there have been no actions commenced
to Landlord’s knowledge threatened by any party for noncompliance therewith.
	 
	 	3.	 	Any and all plumbing, sewer and disposal systems, and pipelines and
tanks, located upon or beneath or servicing the Premises will be maintained in
good and safe operating condition and repair and to Landlord’s knowledge are in
good and safe operating condition and repair.

	 	 	If it is determined during or following the termination or expiration of the Lease that
there is a violation of Environmental Law associated with the leased

 

 

	 	 	premises and the violation was not created by Tenant, its agents, representatives, contractors,
officers, directors, employees, licensees or invitees in violation of Environmental Law then
Landlord agrees to comply with all federal, state, and local laws, ordinances, rules, regulations,
and policies pertaining to such violation that are binding upon Landlord and to take whatever
safety precautions and measures are required or prescribed, at the Landlord’s expense. Landlord
also agrees to defend and indemnify Tenant and its affiliates and their respective agents,
representatives, contractors, officers, directors, employees, licensees and invitees, from and
against all obligations, liabilities, loss, costs, damages, settlement or expenses of whatsoever
kind or nature, known or unknown, contingent or otherwise, directly or indirectly arising out of or
in any way related to any of the following caused solely by Landlord, its agents, representatives,
contractors, officers, directors, employees, licensees or invitees: (i) the presence, disposal,
release or threatened release of any Hazardous Materials on, over, under, from or affecting the
Premises or the soil, water, vegetation, buildings, personal property, persons or animals thereon;
(ii) any personal injury (including wrongful death) or property damage (real or personal) arising
out of or related to such Hazardous Materials; (iii) any lawsuit brought or threatened, settlement
reached or government order relating to such Hazardous Materials; and/or (iv) any violations of
laws, regulations, requirements or demands of government authorities which are based upon or are in
any way related to Hazardous Materials, including, without limitation and in each of the foregoing
cases, reasonable attorney and consultant fees, investigation and laboratory fees, court costs and
litigation expenses. Landlord will notify Tenant in writing immediately of any condition of which
Landlord has knowledge and which involves Hazardous Materials or violation of Environmental Law
which might affect the Premises.exv4w2

 

EXHIBIT 4.2

ARTES MEDICAL, INC.

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

     THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”), is made and
entered into as of June 23, 2006, by and among Artes Medical, Inc., a Delaware corporation (the
“Company”), and each of the individuals or entities whose names are set forth on
Schedule A hereto (each, a “Stockholder” and collectively, the
“Stockholders”).

RECITALS:

     WHEREAS, the Company and the holders of the Company’s Series A Preferred Stock, par value
$0.001 per share (the “Series A Preferred” and such holders, the “Series A
Investors”), have previously entered into an Investors’ Rights Agreement dated as of June 30,
2000 (the “Series A Agreement”).

     WHEREAS, the Company and the holders of the Company’s Series B Preferred Stock, par value
$0.001 per share (the “Series B Preferred” and such holders, the “Series B
Investors”), have previously entered into an Investors’ Rights Agreement dated as of December
15, 2000 (the “Series B Agreement”).

     WHEREAS, the Company and the holders of the Company’s Series C-1 Preferred Stock, par value
$0.001 per share (the “Series C-1 Preferred” and such holders, the “Series C-1
Investors”), have previously entered into an Investors’ Rights Agreement dated as of April 10,
2003 (the “Series C-1 Agreement”).

     WHEREAS, the Company and the holders of the Company’s Series D Preferred Stock, par value
$0.001 per share (the “Series D Preferred” and such holders, the “Series D
Investors”), have previously entered into an Investors’ Rights Agreement dated as of May 1,
2005 (the “Series D Agreement”).

     WHEREAS, the Company and the holders of the Company’s Series E Preferred Stock, par value
$0.001 per share (the “Series E Preferred” and such holders, the “Series E
Investors”) (together with the Series A Investors, the Series B Investors, the Series C-1
Investors and the Series D Investors, the “Prior Investors”), have previously entered into
(a) an Investors’ Rights Agreement dated as of December 22, 2005, (b) an Investors’ Rights
Agreement dated as of December 30, 2005 and/or (c) an Investors’ Rights Agreement dated as of
February 3, 2006 (collectively, the “Series E Agreements”) (together with the Series A
Agreement, the Series B Agreement, the Series C-1 Agreement and the Series D Agreement, the
“Prior Agreements”).

     WHEREAS, the Company and the Prior Investors desire to enter into this Agreement in order to
amend, restate and replace their rights and obligations under the Prior Agreements with the rights
and obligations set forth in this Agreement.

 

 

     WHEREAS, the Series A Agreement may be amended by agreement of the Company and Series A
Investors holding at least a majority of the “Registrable Securities” (as defined in the Series A
Agreement) then outstanding, calculated on an as-converted basis.

     WHEREAS, the Series B Agreement may be amended by agreement of the Company and Series B
Investors holding at least a majority of the “Registrable Securities” (as defined in the Series B
Agreement) then outstanding, calculated on an as-converted basis.

     WHEREAS, the Series C-1 Agreement may be amended by agreement of the Company and Series C-1
Investors holding at least a majority of the “Registrable Securities” (as defined in the Series C-1
Agreement) then outstanding, calculated on an as-converted basis.

     WHEREAS, the Series D Agreement may be amended by agreement of the Company and Series D
Investors holding at least a majority of the “Registrable Securities” (as defined in the Series D
Agreement) then outstanding, calculated on an as-converted basis.

     WHEREAS, each of the Series E Agreements may be amended by agreement of the Company and Series
E Investors holding at least a majority of the “Registrable Securities” (as defined in the
applicable Series E Agreement) then outstanding, calculated on an as-converted basis.

     WHEREAS, the Company has executed this Agreement, and the Prior Investors who are signatories
to this Agreement hold at least that number of shares necessary to amend and restate each of the
Prior Agreements.

AGREEMENT

     NOW, THEREFORE, in consideration of the mutual promises and covenants set forth in this
Agreement and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Company and the Prior Investors who are parties to the Prior Agreements
hereby agree that each of the Prior Agreements is superseded and replaced in its entirety by this
Agreement, including with respect to those Prior Investors who are not signatories to this
Agreement, and the parties hereto further agree as follows:

     1. Restatement and Termination of Prior Agreements. Effective and contingent upon
execution of this Agreement by the Company and the holders of at least a majority of the
“Registrable Securities,” as that term is defined in each of the Prior Agreements, each of the
Prior Agreements is hereby amended and restated in its entirety to read as set forth in this
Agreement and are hereafter terminated and of no further force or effect, and the Company and the
Investors hereby agree to be bound by the provisions hereof as the sole agreement of the Company
and the Investors with respect to registration rights of the Company’s securities and certain other
rights, as set forth herein.

     2. Registration Rights. The Company and the Investors covenant and agree as follows:

2

 

          2.1 Definitions. For purposes of this Section 2:

               (a) “Affiliated Fund” means, with respect to a Holder that is a limited liability
company or a limited liability partnership, a fund or entity managed by the same manager or
managing member or general partner or management company or by an entity controlling, controlled
by, or under common control with such manager or managing member or general partner or management
company.

               (b) “Exchange Act” means the Securities Exchange Act of 1934, as amended (and any
successor thereto) and the rules and regulations promulgated thereunder.

               (c) “Excluded Registration” means a registration statement relating solely to the sale
of securities of participants in a Company stock plan, a registration relating to a corporate
reorganization or transaction under Rule 145 of the Securities Act, or a registration in which the
only common stock being registered is common stock issuable upon conversion of debt securities
which are also being registered.

               (d) “Form S-3” means such form under the Securities Act as in effect on the date
hereof or any successor form under the Securities Act that permits significant incorporation by
reference of the Company’s subsequent public filings under the Exchange Act.

               (e) “Holder” means any Investor owning or having the right to acquire Registrable
Securities or any assignee thereof in accordance with Section 2.12 of this Agreement.

               (f) “IPO” means a firm commitment underwritten public offering by the Company of
shares of its Common Stock prior to or in connection with which all the then-outstanding shares of
Preferred Stock are converted into shares of Common Stock pursuant to the Company’s Amended and
Restated Certificate of Incorporation, as such Amended and Restated Certificate of Incorporation
may be amended from time to time.

               (g) “Major Investor” means any Investor that holds at least 100,000 shares of the
Preferred Stock or the Common Stock issued upon conversion thereof (subject to adjustment for stock
splits, stock dividends, combinations, reclassifications or the like with respect to such shares).
A Major Investor includes any general partners, managing members and affiliates of a Major
Investor, including Affiliated Funds.

               (h) “Register,” “registered,” and “registration” refer to a
registration effected by preparing and filing a registration statement or similar document in
compliance with the Securities Act, and the declaration or ordering of effectiveness of such
registration statement or document.

               (i) “Registrable Securities” means (i)  shares of Common Stock issuable or issued upon
conversion of the Series A Preferred, (ii) shares of Common Stock issuable or issued upon
conversion of the Series B Preferred, (iii) shares of Common Stock issuable or issued upon
conversion of the Series C-1 Preferred (including shares of Series C-1 Preferred issuable upon the
exercise of warrants to purchase shares of Series C-1 Preferred), (iv)

3

 

shares of Common Stock issuable or issued upon conversion of the Series D Preferred (including
shares of Series D Preferred issuable upon the exercise of warrants to purchase shares of Series D
Preferred), (v) shares of Common Stock issuable or issued upon conversion of the Series E Preferred
(including shares of Series E Preferred issuable upon the exercise of warrants to purchase Series E
Preferred), (vi) shares of Common Stock issued or issuable upon the exercise of (x) warrants to
purchase an aggregate of 2,694,571 shares of Common Stock issued in a bridge financing transaction
completed in June 2004 and (y) warrants to purchase an aggregate of 842,969 shares of Common Stock
issued in the Company’s Series D Preferred Stock financing completed in May through June 2005, held
by the Holders and any assignee thereof in accordance with Section 2.12 of this Agreement and any
other shares of Common Stock of the Company issued as (or issuable upon the conversion or exercise
of any warrant, right or other security which is issued as) a dividend or other distribution with
respect to, or in exchange for or in replacement of, the shares listed in (i) through (vi);
excluding, however, in all cases any Registrable Securities sold in a transaction
in which the rights under this Agreement are not assigned, or any shares for which registration
rights have terminated pursuant to Section 2.15 of this Agreement.

               (j) The number of shares of “Registrable Securities then outstanding” shall be
determined by the number of shares of Common Stock outstanding which are, and the number of shares
of Common Stock issuable pursuant to then exercisable or convertible securities which are,
Registrable Securities.

               (k) “SEC” means the Securities and Exchange Commission.

               (l) “Securities Act” means the Securities Act of 1933, as amended, (and any successor
thereto) and the rules and regulations promulgated thereunder.

          2.2 Request for Registration.

               (a) If the Company shall receive at any time after the earlier of (i) January 1, 2008, or
(ii) 180 days after the effective date of registration statement pertaining to an IPO, a written
request from the Holders of a majority of the Registrable Securities then outstanding, voting
together as a single class on an as-converted to Common Stock basis (the “Initiating
Holders”), that the Company file a registration statement under the Securities Act covering the
registration of Registrable Securities with an anticipated aggregate offering price of at least
$25,000,000, then the Company shall, within 20 days after receiving such request, give written
notice of such request to all Holders and shall, subject to the limitations of subsection 2.2(b),
use all commercially reasonable efforts to cause to be registered under the Securities Act all of
the Registrable Securities that each such Holder has requested to be registered within 20 days
after the mailing of such notice by the Company.

               (b) If the Initiating Holders intend to distribute the Registrable Securities covered by their
request by means of an underwriting, they shall so advise the Company as a part of their request
and the Company shall include such information in the written notice referred to in subsection
2.2(a). The underwriter will be selected by the Company, which underwriter shall be reasonably
acceptable to a majority in interest of the Holders whose Registrable Securities are to be included
in the underwriting. In such event, the right of any
Holder to include Registrable Securities in such registration shall be conditioned upon such

4

 

Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable
Securities in the underwriting (unless otherwise mutually agreed by a majority in interest of the
Initiating Holders and such Holder) to the extent provided herein. The Company and all Holders
proposing to distribute their securities through such underwriting shall enter into an underwriting
agreement in customary form with the underwriter or underwriters selected for such underwriting.
Notwithstanding any other provision of this Section 2.2, if the underwriter advises the Company in
good faith that marketing factors require a limitation of the number of shares to be underwritten,
then the Company shall so advise all Holders of Registrable Securities which would otherwise be
underwritten pursuant hereto, and the number of shares of Registrable Securities that may be
included in the underwriting shall be allocated among all participating Holders thereof, including
the Initiating Holders, in proportion (as nearly as practicable) to the amount of Registrable
Securities of the Company owned by each participating Holder. In no event shall any Registrable
Securities be excluded from such underwriting unless all other securities are first excluded from
such offering. Any Registrable Securities excluded from or withdrawn from such underwriting shall
be withdrawn from registration.

               (c) Notwithstanding the foregoing, if the Company shall furnish to the Initiating Holders a
certificate signed by the President of the Company stating that in the good faith judgment of the
Board of Directors of the Company (the “Board of Directors”) it would be seriously
detrimental to the Company and its stockholders for such registration statement to be filed, the
Company shall have the right to defer such filing for a period of not more than 120 days after
receipt of the request of the Initiating Holders; provided, however, that the
Company may not utilize this right or the similar right set forth in Section 2.4(b)(iii) more than
once in any 12-month period, and provided, further, that the Company shall not register any
securities for the account of itself or any other stockholder during such 120-day period (other
than in an IPO or an Excluded Registration).

               (d) In addition, the Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to this Section 2.2:

                    (i) After the Company has effected two (2) registrations pursuant to this Section 2.2 and such
registrations have been declared or ordered effective, provided, however, that such
registrations have been declared or ordered effective and that either (A) the conditions of Section
2.5(a) have been satisfied or (B) the registration statements remain effective and there are no
stop orders in effect to such registration statements;

                    (ii) During the period starting with the date 90 days prior to the Company’s good faith
estimate of the date of filing of, and ending on a date 180 days after the effective date of, a
registration subject to Section 2.3 hereof, unless such offering is not the initial public offering
of the Company’s securities, in which case, ending on a date 90 days after the effective date of
such registration subject to Section 2.3 hereof; provided that the Company is actively employing in
good faith all commercially reasonable efforts to cause such registration statement to become
effective; or

                    (iii) If the Initiating Holders propose to dispose of shares of Registrable Securities that
may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below.

5

 

          2.3 Company Registration.

               (a) If (but without any obligation to do so) at any time after the earlier of (i) January 1,
2008 or (ii) 180 days after the effective date of the registration statement pertaining to an IPO,
the Company proposes to register (including for this purpose a registration effected by the Company
for stockholders other than the Holders) any of its stock under the Securities Act in connection
with the public offering of such securities solely for cash (other than an Excluded Registration or
any registration on any form which does not include substantially the same information as would be
required to be included in a registration statement covering the sale of the Registrable
Securities), the Company shall, at such time, promptly give each Holder written notice of such
registration. Upon the written request of each Holder given within 20 days after mailing of such
notice by the Company in accordance with Section 4.5, the Company shall, subject to the provisions
of Section 2.8, use all commercially reasonable efforts to cause to be registered under the
Securities Act all of the Registrable Securities that each such Holder has requested to be
registered if any stock of the Company is registered.

               (b) The Company shall have the right to terminate or withdraw any registration initiated by it
under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder
has elected to include securities in such registration. The expenses of such registration shall be
borne by the Company, in accordance with Section 2.7 hereof.

          2.4 Form S-3 Registration. In case the Company shall receive from any Holder or
Holders of not less than 30% of the Registrable Securities then outstanding, voting together as a
single class on an as-converted to Common Stock basis, a written request or requests that the
Company effect a registration on Form S-3 with respect to all or a part of the Registrable
Securities owned by such Holder or Holders, the Company will:

               (a) promptly give written notice of the proposed registration, and any related qualification
or compliance, to all other Holders; and

               (b) use all commercially reasonable efforts to effect, as soon as practicable, such
registration and all such qualifications and compliances as may be so requested and as would permit
or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’
Registrable Securities as are specified in such request, together with all or such portion of the
Registrable Securities of any other Holder or Holders joining in such request as are specified in a
written request given within 15 days after receipt of such written notice from the Company;
provided, however, that the Company shall not be obligated to effect any such
registration, qualification or compliance, pursuant to this Section 2.4: (i) if Form S-3 is not
available for such offering by the Holders; (ii) if the Holders, together with the holders of any
other securities of the Company entitled to inclusion in such registration, propose to sell
Registrable Securities and such other securities (if any) at an aggregate price to the public of
less than $1,000,000; (iii) if the Company shall furnish to the Holders a certificate signed by the
President of the Company stating that in the good faith judgment of the Board of Directors, it
would be seriously detrimental to the Company and its stockholders for such registration statement
to be filed, in the Company shall have the right to defer such filing for a period of not more than
120 days after receipt of the request of the Holder or Holders under this Section 2.4;
provided, however, that the Company shall not utilize this right or the similar
right set forth in

6

 

Section 2.2(c) more than once in any 12-month period; (iv) if the Company has,
within the 12-month period preceding the date of such request, already effected two registrations
on Form S-3 for the Holders pursuant to this Section 2.4; (v) in any jurisdiction in which the
Company would be required to qualify to do business or to execute a general consent to service of
process in effecting such registration, qualification or compliance unless the Company is already
qualified to do business or subject to service of process in that jurisdiction; or (vi) during the
period ending 180 days after the effective date of a registration statement subject to Section 2.3.

               (c) Subject to the foregoing, the Company shall file a registration statement covering the
Registrable Securities and other securities so requested to be registered as soon as practicable
after receipt of the request or requests of the Holders. Registrations effected pursuant to this
Section 2.4 shall not be counted as demands for registration or registrations effected pursuant to
Sections 2.2 or 2.3, respectively.

          2.5 Obligations of the Company. Whenever required under this Section 2 to effect the
registration of any Registrable Securities, the Company shall, as expeditiously as reasonably
possible:

               (a) Prepare and file with the SEC a registration statement with respect to such Registrable
Securities and use all commercially reasonable efforts to cause such registration statement to
become effective, and, upon the request of the Holders of a majority of the Registrable Securities
registered thereunder, keep such registration statement effective for up to 120 days, or until the
distribution described in such registration statement is completed, if earlier.

               (b) Prepare and file with the SEC such amendments and supplements to such registration
statement and the prospectus used in connection with such registration statement as may be
necessary to comply with the provisions of the Securities Act with respect to the disposition of
all securities covered by such registration statement for up to 120 days, or until the distribution
described in such registration statement is completed, if earlier.

               (c) Promptly notify the Holders of the effectiveness of such registration statement, and
furnish to the Holders such numbers of copies of a prospectus, including any supplement to the
prospectus, in conformity with the requirements of the Securities Act, and such other documents as
they may reasonably request in order to facilitate the disposition of Registrable Securities owned
by them.

               (d) Following the effective date of such registration statement, notify the Holders of any
request by the SEC that the Company amend or supplement such registration statement, or the
associated prospectus.

               (e) Use all commercially reasonable efforts to register and qualify the securities covered by
such registration statement under such other securities or Blue Sky laws of such jurisdictions as
shall be reasonably requested by the Holders, provided that the Company shall not be
required in connection therewith or as a condition thereto to qualify to do business or to file a
general consent to service of process in any such states or jurisdiction unless the Company is
already qualified to do business or subject to service of process in that jurisdiction.

7

 

               (f) In the event of any underwritten public offering, enter into and perform its obligations
under an underwriting agreement, in usual and customary form, with the managing underwriter of such
offering. Each Holder and other security holder participating in such underwriting shall also
enter into and perform its obligations under such an agreement.

               (g) Notify each Holder of Registrable Securities covered by such registration statement at any
time when a prospectus relating thereto is required to be delivered under the Securities Act of the
happening of any event as a result of which the prospectus included in such registration statement,
as then in effect, includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein not misleading in
the light of the circumstances then existing, such obligation to continue for 120 days or until the
distribution described in such registration statement is completed, if earlier.

               (h) Cause all such Registrable Securities registered pursuant to this Section 2 to be listed
on each national securities exchange or trading system on which similar securities issued by the
Company are then listed.

               (i) Provide a transfer agent and registrar for all Registrable Securities registered pursuant
hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the
effective date of such registration.

               (j) Make generally available to its security holders, and to deliver to each Holder
participating in the registration statement, an earnings statement of the Company that will satisfy
the provisions of Section 11(a) of the Securities Act covering a period of 12 months beginning
after the effective date of such registration statement as soon as reasonably practicable after the
termination of such 12-month period.

          2.6 Information From Holders. It shall be a condition precedent to the obligations of
the Company to take any action pursuant to this Section 2 with respect to the Registrable
Securities of any selling Holder that such Holder shall furnish to the Company such information
regarding such Holder, the Registrable Securities held by it, and the intended method of
disposition of such securities as shall be required to effect the registration of such Holder’s
Registrable Securities. The Company shall have no obligation with respect to any registration
requested pursuant to Section 2.2 or Section 2.4 of this Agreement if, as a result of the
application of the preceding sentence, or the anticipated aggregate offering price of the
Registrable Securities to be included in the registration does not equal or exceed the anticipated
aggregate offering price required to originally trigger the Company’s obligation to initiate such
registration as specified in subsection 2.2(a) or subsection 2.4(b)(ii), whichever is applicable.

          2.7 Expenses of Registration. All expenses other than underwriting discounts and
commissions incurred in connection with registrations, filings or qualifications pursuant to
Sections 2.2, 2.3 and 2.4 including (without limitation) all registration, filing and qualification
fees, printers’ and accounting fees, fees and disbursements of counsel for the Company, and the
reasonable fees and disbursements of one counsel for the selling Holders selected by them with the
approval of the Company, which approval shall not be unreasonably withheld, shall be borne by the
Company; provided, however, that the Company shall not be required to pay for any

8

 

expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4 if the registration
request is subsequently withdrawn at the request of the Holders of a majority of the Registrable
Securities to be registered (in which case all participating Holders shall bear such expenses),
unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one
demand registration pursuant to Section 2.2 or one right to a Form S-3 registration under Section
2.4, as the case may be.

          2.8 Underwriting Requirements. In connection with any offering involving an
underwriting of shares of the Company’s capital stock, the Company shall not be required under
Section 2.3 to include any of the Holders’ securities in such underwriting unless they accept the
terms of the underwriting as agreed upon between the Company and the underwriters selected by the
Company (or by other persons entitled to select the underwriters), and then only in such quantity
as the underwriters determine in their sole discretion will not jeopardize the success of the
offering by the Company. If the total amount of securities, including Registrable Securities,
requested by stockholders to be included in such offering exceeds the amount of securities sold
other than by the Company that the underwriters determine in their sole discretion is compatible
with the success of the offering, then the Company shall be required to include in the offering
only that number of such securities, including Registrable Securities, which the underwriters
determine in their sole discretion will not jeopardize the success of the offering (the securities
so included to be apportioned pro rata among the selling stockholders according to the total amount
of securities entitled to be included therein owned by each selling stockholder or in such other
proportions as shall mutually be agreed to by such selling stockholders). For purposes of the
preceding parenthetical concerning apportionment, for any selling stockholder which is a holder of
Registrable Securities and which is a venture capital fund, or a partnership or corporation, the
Affiliated Funds, members, partners, retired partners and stockholders of such holder, or the
estates and family members of any such partners and retired partners and any trusts for the benefit
of any of the foregoing persons shall be deemed to be a single “selling stockholder,” and
any pro-rata reduction with respect to such “selling stockholder” shall be based upon the aggregate
amount of shares carrying registration rights owned by all entities and individuals included in
such “selling stockholder,” as defined in this sentence.

          2.9 Delay of Registration. No Holder shall have any right to obtain or seek an
injunction restraining or otherwise delaying any such registration as the result of any controversy
that might arise with respect to the interpretation or implementation of this Section 2.

          2.10 Indemnification. In the event any Registrable Securities are included in a
registration statement under this Section 2:

               (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder,
any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who
controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act,
against any losses, claims, damages, or liabilities (joint or several) to which they may become
subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereof) arise out of or are based
upon any of the following statements, omissions or violations (collectively a “Violation”):
(i) any untrue statement or alleged untrue statement of a material

9

 

fact contained in such
registration statement, including any preliminary prospectus or final prospectus contained therein
or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a
material fact required to be stated therein, or necessary to make the statements therein not
misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the
Exchange Act, any state securities law or any rule or regulation promulgated under the Securities
Act, the Exchange Act or any state securities law; and the Company will pay to each such Holder,
underwriter or controlling person, as incurred, any legal or other expenses reasonably incurred by
them in connection with investigating or defending any such loss, claim, damage, liability, or
action; provided, however, that the indemnity agreement contained in this
subsection 2.10(a) shall not apply to amounts paid in settlement of any such loss, claim, damage,
liability, or action if such settlement is effected without the consent of the Company (which
consent shall not be unreasonably withheld), nor shall the Company be liable to any Holder,
underwriter or controlling person for any such loss, claim, damage, liability, or action to the
extent that it arises out of or is based upon a Violation which occurs in reliance upon and in
conformity with written information furnished expressly for use in connection with such
registration by any such Holder, underwriter or controlling person.

               (b) To the extent permitted by law, each selling Holder will indemnify and hold harmless the
Company, each of its directors, each of its officers who has signed the registration statement,
each person, if any, who controls the Company within the meaning of the Securities Act, any
underwriter, any other Holder selling securities in such registration statement and any controlling
person of any such underwriter or other Holder, against any losses, claims, damages, or liabilities
(joint or several) to which any of the foregoing persons may become subject, under the Securities
Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages, or
liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each
case to the extent (and only to the extent) that such Violation occurs in reliance upon and in
conformity with written information furnished by such Holder expressly for use in connection with
such registration; and each such Holder will pay, as incurred, any legal or other expenses
reasonably incurred by any person intended to be indemnified pursuant to this subsection 2.10(b),
in connection with investigating or defending any such loss, claim, damage, liability, or action;
provided, however, that the indemnity agreement contained in this
subsection 2.10(b) shall not apply to amounts paid in settlement of any such loss, claim, damage,
liability or action if such settlement is effected without the consent of the Holder, which consent
shall not be unreasonably withheld; provided, that in no event shall any indemnity under
this subsection 2.10(b) exceed the net proceeds from the offering received by such Holder, except
in the case of willful fraud by such Holder.

               (c) Promptly after receipt by an indemnified party under this Section 2.10 of notice of the
commencement of any action (including any governmental action),
such indemnified party will, if a claim in respect thereof is to be made against any
indemnifying party under this Section 2.10, deliver to the indemnifying party a written notice of
the commencement thereof and the indemnifying party shall have the right to participate in, and, to
the extent the indemnifying party so desires, jointly with any other indemnifying party similarly
noticed, to assume the defense thereof with counsel mutually satisfactory to the parties;
provided, however, that an indemnified party (together with all other indemnified
parties which may be represented without conflict by one counsel) shall have the right to retain
one separate counsel, with the reasonable fees and expenses to be paid by the indemnifying party,
if

10

 

representation of such indemnified party by the counsel retained by the indemnifying party would
be inappropriate due to actual or potential differing interests between such indemnified party and
any other party represented by such counsel in such proceeding. The failure to deliver written
notice to the indemnifying party within a reasonable time of the commencement of any such action,
if prejudicial to its ability to defend such action, shall relieve such indemnifying party of any
liability to the indemnified party under this Section 2.10, but the omission so to deliver written
notice to the indemnifying party will not relieve it of any liability that it may have to any
indemnified party otherwise than under this Section 2.10.

               (d) If the indemnification provided for in this Section 2.10 is held by a court of competent
jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim,
damage or expense referred to therein, then the indemnifying party, in lieu of indemnifying such
indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified
party as a result of such loss, liability, claim, damage, or expense in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions that resulted in such
loss, liability, claim, damage or expense as well as any other relevant equitable considerations;
provided, that in no event shall any contribution by a Holder under this Subsection 2.10(d)
exceed the net proceeds from the offering received by such Holder, except in the case of willful
fraud by such Holder. The relative fault of the indemnifying party and of the indemnified party
shall be determined by reference to, among other things, whether the untrue or alleged untrue
statement of a material fact or the omission or alleged omission to state a material fact relates
to information supplied by the indemnifying party or by the indemnified party and the parties’
relative intent, knowledge, access to information, and opportunity to correct or prevent such
statement or omission.

               (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and
contribution contained in the underwriting agreement entered into in connection with the
underwritten public offering are in conflict with the foregoing provisions, the provisions in the
underwriting agreement shall control.

               (f) The obligations of the Company and Holders under this Section 2.10 shall survive the
completion of any offering of Registrable Securities in a registration statement under this
Section 2, and otherwise.

          2.11 Reports Under the Exchange Act. With a view to making available to the Holders
the benefits of Rule 144 promulgated under the Securities Act and any other rule or regulation of
the SEC that may at any
time permit a Holder to sell securities of the Company to the public without registration or
pursuant to a registration on Form S-3, the Company agrees to:

               (a) make and keep public information available, as those terms are understood and defined in
SEC Rule 144, at all times after 90 days after the effective date of an IPO so long as the Company
remains subject to the periodic reporting requirements under Sections 13 or 15(d) of the Exchange
Act;

               (b) take such action, including the voluntary registration of its Common Stock under
Section 12 of the Exchange Act, as is necessary to enable the Holders to

11

 

utilize Form S-3 for the
sale of their Registrable Securities, such action to be taken as soon as practicable after the end
of the fiscal year in which the first registration statement filed by the Company for the offering
of its securities to the general public is declared effective;

               (c) file with the SEC in a timely manner all reports and other documents required of the
Company under the Securities Act and the Exchange Act; and

               (d) furnish to any Holder upon request, so long as the Holder owns any Registrable Securities,
(i) a written statement by the Company that it has complied with the reporting requirements of SEC
Rule 144 (at any time after 90 days after the effective date of an IPO), the Securities Act and
the Exchange Act (at any time after it has become subject to such reporting requirements), or that
it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after
it so qualifies), (ii) a copy of the most recent annual or quarterly report of the Company and such
other reports and documents so filed by the Company, and (iii) such other information as may be
reasonably requested in availing any Holder of any rule or regulation of the SEC which permits the
selling of any such securities without registration or pursuant to such form.

          2.12 Assignment of Registration Rights. The rights to cause the Company to register
Registrable Securities pursuant to this Section 2 may be assigned (but only with all related
obligations) by a Holder to a transferee or assignee (a) of at least 25,000 shares of such
securities (subject to adjustment for stock splits, stock dividends, reclassification or the like
with respect to such shares) (or if the transferring Holder owns less than 25,000 shares of such
securities, then all Registrable Securities held by the transferring Holder), (b) that is a
subsidiary, parent, partner, limited partner, retired partner, member, retired member or
stockholder of a Holder, (c) that is an Affiliated Fund, (d) who is a Holder’s child, stepchild,
grandchild, parent, stepparent, grandparent, spouse, sibling, mother-in-law, father-in-law,
son-in-law, daughter-in-law, brother-in-law, or sister-in-law (such a relation, a Holder’s
“Immediate Family Member”, which term shall include adoptive relationships), or (e) that is
a trust for the benefit of an individual Holder or such Holder’s Immediate Family Member,
provided the Company is, within a reasonable time after such transfer, furnished with
written notice of the name and address of such transferee or assignee and the securities with
respect to which such registration rights are being assigned; and provided,
further, that such assignment shall be effective only if the transferee agrees in writing
to be bound by this Agreement and immediately following such transfer the further disposition of
such securities by the transferee or assignee is restricted under the Securities Act. For the
purposes of determining the number of shares of Registrable Securities held by a transferee or
assignee, the holdings of transferees and assignees of (x) a partnership who are partners or
retired partners of such partnership or (y) a limited liability company who are members or retired
members of such limited liability company (including Immediate Family Members of such partners or
members who acquire Registrable Securities by gift, will or intestate succession) shall be
aggregated together and with the partnership or limited liability company; provided that all
assignees and transferees who would not qualify individually for assignment of registration rights
shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices or
taking any action under Section 2.

          2.13 Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company shall not, without the prior written consent of the Holders

12

 

of a majority of
the outstanding Registrable Securities, enter into any agreement with any holder or prospective
holder of any securities of the Company which would allow such holder or prospective holder (a) to
include any of such securities in any registration filed under Section 2.2 hereof, unless under the
terms of such agreement, such holder or prospective holder may include such securities in any such
registration only to the extent that the inclusion of his securities will not reduce the amount of
the Registrable Securities of the Holders which is included or (b) to make a demand registration
which could result in such registration statement being declared effective prior to the earlier of
either of the dates set forth in subsection 2.2(a) or within 120 days of the effective date of any
registration effected pursuant to Section 2.2.

          2.14 Lock-Up Agreement.

               (a) Lock-Up Period; Agreement. In connection with the initial public offering of the
Company’s securities and upon request of the Company or the underwriters managing such offering of
the Company’s securities, each Holder shall not sell, make any short sale of, loan, grant any
option for the purchase of, or otherwise dispose of any securities of the Company, however or
whenever acquired (other than those included in the registration) without the prior written consent
of the Company or such underwriters, as the case may be, for such period of time (not to exceed 180
days, but subject to such extension or extensions as may be required by the underwriters in order
to publish research reports while complying with the Rule 2711 of the National Association of
Securities Dealers, Inc.) from the effective date of such registration as may be requested by the
Company or such managing underwriters, and shall execute an agreement reflecting the foregoing as
may be requested by the underwriters at the time of the Company’s initial public offering.

               (b) Limitations. The obligations described in Section 2.14(a) shall apply only if all
officers and directors of the Company and all greater than 5% stockholders enter into similar
agreements, and shall not apply to a registration relating solely to employee benefit plans, or to
a registration relating solely to a transaction pursuant to Rule 145 under the Securities Act.

               (c) Stop-Transfer Instructions. In order to enforce the foregoing covenants, the
Company may impose stop-transfer instructions with respect to the securities of each Holder (and
the securities of every other person subject to the restrictions in Section 2.14(a)).

               (d) Transferees Bound. Each Holder agrees that prior to the Company’s initial public
offering it will not transfer securities of the Company unless each transferee agrees in writing to
be bound by all of the provisions of this Section 2.14.

               (e) Each Holder agrees that a legend reading substantially as follows shall be placed on all
certificates representing all Registrable Securities of each Holder (and the shares or securities
of every other person subject to the restriction contained in this Section 2.14):

THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A LOCK-UP PERIOD
OF UP TO 180 DAYS AFTER THE EFFECTIVE DATE OF THE ISSUER’S REGISTRATION
STATEMENT

13

 

FILED UNDER THE ACT, AS AMENDED, AS SET FORTH IN AN AGREEMENT BETWEEN
THE COMPANY AND THE ORIGINAL HOLDER OF THESE SECURITIES, A COPY OF WHICH MAY BE
OBTAINED AT THE ISSUER’S PRINCIPAL OFFICE. SUCH LOCK-UP PERIOD IS BINDING ON
TRANSFEREES OF THESE SHARES.

          2.15 Termination of Registration Rights. No Holder shall be entitled to exercise any
right provided for in this Section 2 after the earlier of (a) five (5) years following the
consummation of an IPO, (b) with respect to any Holder, at such time after the IPO as Rule 144 or
another similar exemption under the Securities Act is available for the sale of all of such
Holder’s shares during a three-month period without registration, or (c) upon termination of the
Agreement, as provided in Section 4.2.

     3. Covenants of the Company.

          3.1 Delivery of Financial Statements. The Company shall deliver to each Major
Investor (other than a Major Investor reasonably deemed by the Company to be a competitor of the
Company):

               (a) as soon as practicable, but in any event within 120 days after the end of each fiscal year
of the Company (or such longer period of time as may be required by the Company’s independent
public accountants), an income statement for such fiscal year, a balance sheet of the Company and
statement of stockholder’s equity as of the end of such year, and a statement of cash flows for
such year, such year-end financial reports to be in reasonable detail, prepared in accordance with
U.S. generally accepted accounting principles (“GAAP”), and audited and certified by an
independent public accounting firm of nationally recognized standing selected by the Company;

               (b) as soon as practicable, but in any event within 45 days after the end of each of the first
three quarters of each fiscal year of the Company, an unaudited profit or loss statement, a
statement of cash flows for such fiscal quarter and an unaudited balance sheet as of the end of
such fiscal quarter;

               (c) within 30 days of the end of each month, an unaudited income statement and a statement of
cash flows and balance sheet for and as of the end of such month, in reasonable detail;

               (d) as soon as practicable, but in any event prior to the end of each fiscal year, a budget
and business plan for the next fiscal year, prepared on a monthly basis, and, as soon as prepared,
any other updated or revised budgets for such fiscal year prepared by the Company; and

               (e) with respect to the financial statements called for in subsections (b) and (c) of this
Section 3.1, an instrument executed by the Chief Financial Officer or President of the Company and
certifying on behalf of the Company that such financials were prepared in accordance with GAAP
consistently applied with prior practice for earlier periods (with the exception of footnotes that
may be required by GAAP) and fairly present the financial condition

14

 

of the Company and its results
of operation for the period specified, subject to year-end audit adjustment, provided that the
foregoing shall not restrict the right of the Company to change its accounting principles
consistent with GAAP, if the Board of Directors or a committee thereof determines that it is in the
best interest of the Company to do so.

          3.2 Inspection. The Company shall permit each Major Investor (except for a Major
Investor reasonably deemed by the Company to be a competitor of the Company), at such Major
Investor’s expense, to visit and inspect the Company’s properties, to examine its books of account
and records and to discuss the Company’s affairs, finances and accounts with its officers, all at
such reasonable times as may be requested by the Major Investor; provided, however,
that the Company shall not be obligated pursuant to this Section 3.2 to provide access to any
information which it reasonably considers to be a trade secret or similar confidential information.

          3.3 Termination of Covenants. The covenants set forth in Sections 3.1 and 3.2 shall
terminate as to each Holder and be of no further force or effect (a) immediately prior to the
consummation of an IPO, (b) when the Company first becomes subject to the periodic reporting
requirements of Sections 13 or 15(d) of the Exchange Act or (c) upon termination of this Agreement,
as provided in Section 4.2, whichever is the earliest to occur.

     4. Miscellaneous.

          4.1 Waiver of Registration Rights. Effective and contingent upon execution of this
Agreement by the Company and the holders of at least a majority of the “Registrable Securities,” as
that term is defined in each of the Prior Agreements, any and all rights of the holders of
Registrable Securities under the Prior Agreements to register and sell their Registrable Securities
or any other securities of the Company held by such holders as part of or in connection with the
proposed initial public offering of the Company’s Common Stock pursuant to that certain
Registration Statement on Form S-1 (File No. 333-134086), filed with the Securities and Exchange
Commission on May 12, 2006, are hereby waived.

          4.2 Termination. This Agreement shall terminate, and have no further force and
effect, (a) upon the closing of a Sale of the Company (as defined below) or (b) upon the written
agreement of the Company and the holders of a majority of the Registrable Securities then
outstanding, voting together as a single class on an as-converted to Common Stock basis. For
purposes of this Section 4.2, a “Sale of the Company” shall include a sale, lease, or other
disposition of all or substantially all of the Company’s assets or business or the Company’s merger
into or consolidation with any other corporation or other entity, or any other corporate
reorganization, in which the holders of the Company’s outstanding voting stock immediately prior to
such transaction own, immediately after such transaction, securities representing less than fifty
percent (50%) of the voting power of the corporation or other entity surviving such transaction,
provided that a Sale of the Company shall not include a merger effected exclusively for the purpose
of changing the domicile of the Company or a sale of shares by the Company for primarily equity
financing purposes.

          4.3 Entire Agreement. This Agreement constitutes the entire agreement between the
parties hereto pertaining to the subject matter hereof, and any and all other written

15

 

or oral
agreements relating to the subject matter hereof existing between the parties hereto, including
without limitation, the Prior Agreements, are expressly terminated and canceled.

          4.4 Successors and Assigns. Except as otherwise provided in this Agreement, the terms
and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
permitted successors and assigns of the parties (including transferees of any Preferred Stock or
any Common Stock issued upon conversion thereof). Nothing in this Agreement, express or implied,
is intended to confer upon any party other than the parties hereto or their respective successors
and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement,
except as expressly provided in this Agreement.

          4.5 Amendments and Waivers. Any term of this Agreement may be amended or waived only
with the written consent of the Company and the Investors holding a majority of the Registrable
Securities then outstanding. Notwithstanding the foregoing, this Agreement may be amended with
only the written consent of the Company for the sole purpose of including additional purchasers of
Preferred Stock as “Investors” and “Holders.” Any amendment or waiver effected in accordance with
this paragraph shall be binding upon each party to the Agreement, whether or not such party has
signed such amendment or waiver, each future holder of all such Registrable Securities, and the
Company.

          4.6 Notices. Unless otherwise provided, any notice required or permitted by this
Agreement shall be in writing and shall be deemed sufficient upon delivery, when delivered
personally or by overnight courier or sent by facsimile, or 48 hours after being deposited in the
U.S. mail, as certified or registered mail, with postage prepaid, and addressed to the party to be
notified at such party’s address or facsimile number as set forth on Exhibit A hereto or as
subsequently modified by written notice.

          4.7 Severability. If one or more provisions of this Agreement are held to be
unenforceable under applicable law, such provision shall be excluded from this Agreement, and the
balance of the Agreement shall be interpreted as if such provision were so excluded and shall be
enforceable in accordance with its terms.

          4.8 Governing Law. This Agreement and all acts and transactions pursuant hereto shall
be governed, construed and interpreted in accordance with the laws of the State of California,
without giving effect to principles of conflicts of laws.

          4.9 Counterparts. This Agreement may be executed in two or more counterparts,
including facsimiles, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

          4.10 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

          4.11 Aggregation of Stock. All shares of the Preferred Stock held or acquired by
affiliated entities or persons shall be aggregated together for the purpose of determining the
availability of any rights under this Agreement.

16

 

[Signature Pages Follow]

17

 

     IN WITNESS WHEREOF, the parties hereto have executed this Amended and Restated Investors’
Rights Agreement as of the day and year first above written.

	 	 	 	 	 	 	 
	 	 	Artes Medical, Inc.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Stefan M. Lemperle, M.D.	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Stefan M. Lemperle, M.D.	 	 
	 

	 	 	 	Chief Executive Officer	 	 
	 
	 	 	 	 	 	 
	INVESTOR:

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	(if applicable)	 	 

[COUNTERPART SIGNATURE PAGE TO

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

Schedule A

PARTIES TO

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

111 Development Corp.

A&S Levy Family Holdings, LLLP — Arthur & Susan Levy TTEEs

A.G. Edwards & Sons, Inc. C/F James G. Morrissey Ira

Aadil Zaman

Aaron Wesslink

Abdul W. Kazi

Adam Rappoport

Adi Corporation

Adi Ruegg

Afshar Ghotli Family Trust

Agricultural Benefits

Ahmad Ghaffari

Ahmad Zarei

Aimee D. Ellingsen & Charles H. Krekelberg, Husband & Wife, as Joint Tenants

Alan Abrams

Alan J. Young

Alan Joseph

Alan Loghman

Alan M. Shafer

Alavi Intervivos Trust

Albert J. Sabini IRA

Albert J. Schmid Family Limited

Alex Lethen

Alex Simms

Alexander Petrovic

Alexandra Gessler

Alfred Bernegger

Alfred H. Fischer

Alfred T. Peteroy

Ali Pourhosseini

Ali Reza Soltan

Alireza Haeri

Aman U. Syed

Amir Jamali

Anand R. and Sucheta Baichwal

Andrea Book Riggs

Andreas Engel

Andreas Klainguti

Andreas Lemperle

 

 

Andreas Mauser

Andrew & Aura Jackson JTWROS

Andrew and Laura Fraser

Andrew H. Sabreen Revocable Trust

Andrew Heinle

Andrew J. Conrad, Ph.D.

Andrew Meltzer

Angelo J. Carrera

Angelyn Scarvaci Revocable Trust

Anita B. Suson Children’s 1999 Trust

Ann T. Thomas Separate Property Trust

Anthony Fiorello

Anthony M. Lacenere

Anthony Vassallo and Mary Ellen Vassallo

Anthony Vassallo SEP IRA

Anthony Vitale

Anton Meile

AquaFauna Bio-Marine Inc. Profit Sharing Plan

Arda Yalvac

Ardeschir Pourfard

Arjang Miremadi

Arne Zimmerman

Arthur Caputo

Ashland Partners

Ashnik Management

Astrid Ruegg

Astrid Schmidt

Axel Lang

Babak Aghamohammadi

Bahr Family Limited Partnership, The

Baldassare Nastasi

Baltimore Business Leaders, LLC

Bank Wegelin & Co.

Barbara Adelglass

Barbara K. Bloom, Trustee, Arthur M. Bloom & Barbara K. Bloom Family Trust U.T.D.
9/21/84

Barclay M. Armitage Trust

Barry & Laura Silberman

Barry J. Galt

Barry J. Lind Revocable Trust

Barry J. West

Beck und Schick

Ben Yoon

Benjamin Kopf III

Benjamin Raab Trust

Bernadette Marxer

 

 

Bernard & Carey Simkin

Bernard & Rene Breier

Biagio & Assunta Didino JTWROS

Billy J. Sayers

Bloching/Moll u.la.

Block Family Trust

Block Family Trust — Carleton & Barbara Block TTEEs

Bobby H. Bryan SEP IRA

Bonnie Callan

Brad Cuvelier

Bradley Sallwasser

Brenda G. Mapp

Brent J. Farrell

Bret A. Young

Brett Snyder, Dr.

Britt Krebs

Bruce E. Bacon

Bruce W. Fecht

Bruno Helbling

Bruno Weber, Prof.

C. David & Patrice Schenkel JTWROS

C. Dennis Bucko

Cabin Trust Dated June 13, 1997, The

Calman J. Zamoiski, Jr.

Camille Lieners

Canderm Pharma

Carl F. Berner, MD

Carl J. Sagasser Living Trust

Carmen Oesterle

Charles Beardsley

Charles E. Helsley

Charles E. Helsley IRA

Charles M. Ewell

Charles M. Vanderford & Ginger L. Vanderford

Charles P. Wilkins

Charles Schumann

Charles Vaske

Charlie Harb

Chris Jones

Chris M. Cioffi

Christer Hedstrom

Christian Coluccio

Christian F. Coluccio SEP IRA

Christian Krebs

Christian Wolf

 

 

Christine Campagna Rev. Trust

Christine Hughes

Christoph Helg

Christoph Scholze

Christopher A. Jones

Christopher Barczewski

Christopher Dale

Christopher Holbech & Gregg Rudenberg

Christopher J. Gahman

Christopher J. Reinhard

Christopher Krebs

Christopher M. Jasak

Christopher Reinhard

Cicero Finance Inc.

Cirrus Motion Media

Citigroup Global Markets, Inc. as IRA Custodian FBO Daymon Kenyon

City National Bank, TTEE PCHS 401k Plan FBO Michael Kinkelaar

Claudia C. Rouhana

Claus Klohk

Clemens Laternser

Cole & Associates

Comerica Bank

Cory Slovik

Craig R. Whited

Creative Microspheres

Crown Metal Mfg. Co.

Crown Metal Profit Sharing Plan

Cyril Thomas

D.G. Ruby

Dan & Brenda Davidson JTWROS

Dan Edgarton

Dandy Lee

Daniel & Deborah Glazer JTWROS

Daniel A. Johnson

Daniel C. Berl

Daniel Davis

Daniel I. & Sally E. Waki

Daniel Lee

Daniel Lord

Daniel M. & Mary Ellen Coombs

Darell F. Norris

Darrel Brodke

Darshan & Harprit Dhiman

Dave McCoy

Dave Vroubel

 

 

Dave Wicker

David & Jean Bernstein

David & Juliana Lipschultz

David & Rhoda Narins

David A. K. Duncan

David A. Wilson

David A. Wilson SEP IRA

David B. Baird, III

David Berman

David Edfors

David H. Slater and Marla Slater JTWROS

David J. Raab

David K. Basile

David Keefe

David L. Begent

David L. Richardson

David Louis Begent

David P. & Denise M. Booth

David Quelle

David R. Preston

David R. Preston & Associates, A.P.C.

David Raimo

David Shively

David Vitale

David W. Brooks

David W. Brooks and Janet M. DiPrinzio

David W. Brooks IRA 8011-7923 UTA Charles Schwab & Co., Inc. Cust

David W. Drezner

Dayle E. O’Connor

Daymon Kenyon

Dean Snyder

Dennis Booth

Dennis Fortin

Dennis J. Hurwitz, MD

Dennis M Nigro, MD

Derby Family Living Trust

Derek S. Cowling

Derek Samuel

Derezin Breier & Delson Profit Sharing Plan Trust B

Diana Laird

Dieter Simonson

Dirk Jakob

DJB Holdings, LLC

DL Capital Group, LLC

Dominic Coluccio

 

 

Donald A. Glassberg

Donald J. Ponec TTEE Ponec Trust

Donald Taddoni

Donald Zimmerman, Wesley Pickard & Terrence Colvin

Donald Zone and Mary Louise Zone JTWROS

Dora Roellin

Dorin Radu

Douglas Saunders IRA

Dr. Hannes Schierle, Prof.

Durango Spine LLLP

Dwight H. DeSantis Trust Dated 1/1/04

E.M.R.E., LLC

Eagle Trust

Edward C. Roohan

Edward Gabrielson IRA, Dr.

Edward K. McCullough

Edward K. Quinby

Elizabeth C. Baldwin

Elizabeth Sandor

Ellen E. Larson and Floyd G. Larson as Community Property

Ellen Farrell

Emanuel & Rose Diteresi

Emile & Ursula Misiraca

Enaiatolah Eftekhary

Epsten Family Trust U.T.D. 7-25-90, Mary H. Epsten, Trustee

Eric F. L. Romilly

Eric Lyon

Eric Lyon SEP IRA

Eric Scott & Robin A. Turner

Ernesto Marquez

Ernst Meier

Eugene Mark Shusterman, M.D.

Evonne & Michele Stellato

Fabio Migliaccio

Felicitas Hourand-Weber

First Roseland Pension & Profit Sharing Plan

Floyd & Ellen Larson

Frank A. Hofstetter

Frank Codispoti Revocable Trust

Frank P. Russo and Joann C. Russo Trustees of the F & J Russo Family Trust U/D/T

Dated August 3, 2000

Frank Perretti

Frank R. & Donna R. Deis

Frank S. Teixeira

Franz Pierre

 

 

Fred B. & Marjory B. Goldman TIE

Frederick R. McConnaughey

Frederick Sandvick

Gabor Rubanyi

Gabriele Nicolo

Gail Gobbato Salvatierra

Galileo Tignini

Garry Ard

Gary D. Heihn

Gary Fischer

Gary Handleman & Donna Lobos

Gary Kenneth Parsons

Gary Nicoletti

Gebhard Michael

Georg Gmur, Dr.

George Colella

George J. Schmitt

George Manos

Gerald E. Gillett Trust

Gerald R. Haas

Gerard J. Zeppieri

Gerhard Quelle

Gero G. Papst

Gilbert A. Flores Management Trust, The

Gilbert M. Flores

Giovanni Minuz

Gity Afshar

Glenn Hechler

Gordon G. Kaplan

GPM Globo Portfolio Management AG

Grant B. Keefer

Gregg Rudenberg

Gregg Zeoli

Gregg Zeoli SEP IRA

Gregory Anderson

Gregory Kirk Ragland

Gregory Schneider

Gregory Schneider Inc Super Simplified 401k FBO Gregory Schneider

Gregory W. Schneider

GSW Holdings, LLC

Gwen A. Huntley

H. Michael Roark, MD

Hajo Feldmann

Hallock Family Trust, U/D/T, November 23, , 2004, The

Hamid R. Quraishi

 

 

Hamid Sadeghi

Han Lei Wan, MD

Hanne Raymond

Hannes Schierle

Hans Geser

Hans H. Sammer

Hans Peter Zweifel

Hans-Peter Thoma, Dr.

Harbor View Investments, LTD.

Harish H. Shah

Harry Booth

Harry Forman

Harry G. Cooper Trust

Harry L. and Diane Smith

Harvey Abrams, MD

Haven Mfg. Co.

Hector A. Montiel

Heidi Muller-Schild

Heinz Bernegger

Heinz Boksberger

Heinz Kitt

Henrik Vester Christensen Holdings APS

Henry H. Bahr QTIP Trust, The

Henry N. Millner and Rachael Jeck, as Trustees of the Millner/Jeck Trust Agreement,

dated August 3, 2005

Henry Sandbach

Henry Teichholz & Julie Teichholz

Henry W. Trulson or Karen A. Trulson

Homayoun Pourshirazi, Dr.

Horst & Sylviane van der Linden

Horst Van Der Linden

Hossein Sattari

Howard & Melanie Kollinger JTWROS

Howard Bergtraum

Huxley Richardson

Ian L. Kessler

IC-1, LLC

iNetworks, LLC

International Electronic Business Inc.

Investors Club, L.L.C.

Ira B. Blank

Ira Spodek

Irina Serpoukhouvitina

Isaac Moreno

J & C Resources LLC

 

 

J S Cole

J. Scott Phillips IRA

Jack Bruscianelli

Jackson Investment Group LLC

James A. Gerali Revocable Trust Dated 3/17/89 amended 9/14/98

James A. Lesley & Judy B. Lesley JTWROS

James and Judi Nonn

James Buckman

James C. Holmes

James E. Stonhaus or Janis S. Stonhaus

James Garrett Schwendig

James H. Stonhaus

James Hendren

James M. & Sophia L. Schmidt

James Metelski

James Morrissey

Jamil H. Khan

Jamshid Hamidi

Janet Silveira

Janice Dickinson

Jason D. Young

Jay S. Orringer and Jolynne V. Orringer

Jay Silberman & Judith Silberman JTWROS

Jeffrey A. Young

Jeffrey Adelglass M.D., P.A. Profit Sharing

Jeffrey C. Allard

Jeffrey C. Newman

Jeffrey C. Wang

Jeffrey Chandler

Jeffrey Sperber

Jeffrey T. Ramsey and Monique E. Ramsey Family Trust UTD 12/31/1996

Jehangir Arjoman Kermani

Jennifer & Matthew S. Olesen, Husband & Wife, as Joint Tenants

Jennifer R. Bancroft

Jens Becker

Jerald A. Blumberg

Jessie J. Knight, Jr

Jim Muir

Jitin Dhiman

JoAnn Daszkowski

Joel & Beverly Seligson

Joel Littlefield

Joerg Obwegeser, Dr.

Johan E Brahme, MD Inc. Defined Benefit Plan

Johann Vollmost

 

 

John & Martha Reilly

John A. Abraham

John A. Zeeb

John Ahern

John and Carolyn Davis JTWROS

John and Maria P. Russo Trustees of the J & M Russo Family Trust U/T/D Dated August 3, 2000

John Angelos

John C. Giordano, Jr. & Andrea J. Giordano

John D. Felton

John H. Joseph Revocable Living Trust

John J. Horn

John M. Wander

John Olbrich

John Pierre Ayala

John Risley & Cindy Risley

John Scheidt

John Schleyer

John Schmidt

John Schrage

John Thomas Holly SEP IRA

John Zeeb

Jone Hsia

Joon Rhee

Josef Muller-Schild

Josef Thalmann

Joseph & Tracy Rudman

Joseph A. Nebel, Jr.

Joseph A. Nebel, Sr.

Joseph B. Panella IRA

Joseph Cavegn

Joseph Family Living Trust

Joseph M. Cicini

Joseph Pitta

Joseph Sorbara

Joseph V. Fisher

Joseph W. Glancy

Judson LeGrand

Juerg F. Tschopp

Jui-Shen Hsu

Julian Stephen Schmidt

Jurgen Frei

Justin Kaplan

Kamran Hamidi

Karen M. Doyle

Karen Smith

 

 

Karl E. Lundberg

Karl Gmur and Vreni Gmur

Karl+Vreni Gmur

Karla R. Kelly, A ProfessionalLaw Corporation

Karl-Christoph Steiner

Katherine Lynn Ammann

Kathleen & Richard Bryson

Kay Seibert

Keith J. Rowe

Keith Nebel

Keller Anton, Dr.

Kelly A. Bownes

Kelly-Grant Living Trust U/A Dtd 12/12/96

Kelsie Derkatz

Ken & Karen Lehman

Ken Satterlee

Kenneth L. & Sharon W. Kincel

Kenneth Steel

Kenton L. Eiffert IRA

Kevin Clarkin

Kevin Green

Kevin Sheldon IRA

Kevin Spizizen Inherited IRA

Kevin T. Nini

Khan Enterprises

Khanh D. Tran

Kiun Chu

Knowles Family Trust

Knut Krecker

Kris Bjornson

Krispin Rosner

Kristine Jacques

Kupfer Family Trust dated March 6, 1993

Kurt Sturzenegger

La Femme Investments, Inc.

Lane Deyoe

Larry Bishop

Laura A. Olesen

Laurence D. Bloom

Lawrence E. Twork

Lawrence P. Giardina IRA

Lawrence Silver

Leandra A. Hiyane

Lee D. Clark

Lee Family Trust, The

 

 

Lee Roy Pearson, III

Legg Mason Wood Walker, Incorporated

Leipe & Sshulz u.a. GBR mbH

Leo Satriawan

Leonard DeOliveira

Leonard Giampaolo and James Lau

Leonard S. Yaffe

Lewis Levy and Barbara Ilene Levy

Lichter Venture Group Defined Benefit Plan Trust

Lisa Ann Nicole

Lisa Bea Alton Anderson

Lisa Marie Ellingsen

Living Trust of Dale Kann

Lois Joyce Richmond

Lon E. Otremba

Lone Jack Ranch, LP

Long Island Auto Realty

Lori H. Saltz

Louis A. Shpritz

Louis Angelos

Louis Beacham

Louis M. Giardina Roth IRA

Luis A. Queral , Dr.

Luther Daniel Mears and Susan Fielder Mears

Lynnette Meltz

M & M Investment

M. Lou Marsh

Magnus Coxner

Mahendra R. Sanapati

Malcolm Tovey

Manchester Financial Group, L.P.

Manual Norman Leonard

Marc Goldman

Marcel Wermuth

Margrith Oehri

Margrith Thoma-Sutter

Maria A. Allnutt

Mario Gioia

Mark A. Ratteree

Mark Brenner

Mark G. Rubin

Mark Goldman

Mark Goldwasser

Mark Gonwa, MD

Mark Nebel

 

 

Mark Niederost

Mark Ransom

Markus Meyer, M.D.

Markus Schaub

Marlene J. Winker Trust — James & Marlene Winker Trustees

Marshall Family Charitable Unitrust

Marshall R. Chesrown

Marshall Trabout, Dr.

Martha Keller

Martha Medich

Martin L. Karlov

Martin Moehr

Martina Wolber

Martine Timmermans

Mary H. Epsten

Mary N. Wilson IRA

Marylou Shanahan

Mashallah Afshar

Mathias Widmer

Matt Portes

Matthew Bernstein

Matthew Mega

Matthew Silberman

Matthias Benken

Matthias Schulz

Maureen Chilelli

Maureen Crowe Productions FBO Maureen Crowe

Maurice Panichi & Canzio Joe Panichi TIC

Mehrdad Majlessi

Melissa Medich

Mendel N. Nudelman

Merrel Olesen MD

Michael Andrew Grosner

Michael Atallah

Michael Bogue

Michael Cardinale & Joseph Agosta

Michael F. Glazer and Ellen R. Glazer JTWROS

Michael Filingeri

Michael Gebhard

Michael Guffanti

Michael H. & Victoria L. McGeath

Michael Hancock

Michael Hourand, Dr.

Michael J. Haley

Michael L. Simms

 

 

Michael Mega

Michael P. Silva

Michael Sauerbrier, Prof.

Michael T. Loffredo

Michael W. Hicks

Michele B. Ellingsen

Michele Bonvillain Ellingsen, Ellingsen Revocable Declaration of Trust dated 12/3/04

Mike Burkoff

Millard P. Thaler & Zeena I. Ubogy

Milton Cohen & Steven R. Cohen Trustees under the Milton Cohen Trust Agreement

dated November 10, 2005

Minipuri G. Ramesh Singh

Mira Habel

Mirza Alladina Medical, Ltd

Mission Consultant, Inc.

Mitchell & Ilene Slovik

Mitchell A. Fried

Moazzem H. Chowdhury

Mohsen Shahbani And Deborah K. Shahbani

Mones International, Inc.

Morgan J. C. Scudi

Morris Moses

MSB Family Trust

Murray Berman

Myron H. and Mercedes L. Budnick

Naser Ostad

Nasri Investment, LLC

Nathalie Ransom

Nathaniel Silon Revocable Living Trust

National Securities Corporation

Neil & Estelle Marcus

Nelson Penarreta & Patricia Davila JTWROS

Neville Alleyne, MD

NGN BioMed Opportunity I GmbH & Co. Beteiligungs KG

NGN Biomed Opportunity I, L.P.

Nhu Y. Huynh

Nicholas Abbate

Nicholas C. Scott

Nicholas Erik Sieveking, MD

Nike Partners, LP

Nikhil & Sheila Sheth

Niklas Neumann

Nitin Sharma

Noah Drezner

Nolan E. Johnson

 

 

Opal Investments Management, Inc.

Optimum Health Services

Ostanik Family Trust Initially Created 3/6/03

Pamela Esposito

Pao-Ying & Chen-Huang

Partnership”

Parviz Roubeni & Rad Roubeni JTWROS

Patricia Charman

Patricia Klier

Patricia L. Novak

Patrick Bownes

Patrick Sheridan IRA Rollover

Patrick T. & Patricia M. Wooten

Paul & Ann Thomas Community Property Trust

Paul A. Felleti

Paul Becker

Paul Berlin

Paul D. Sherr, P.C. Defined Benefit Pension Plan

Paul Porter

Paul Schneider

Paul Treger

Paul Zlotnik

Paula McKinney

Perfectum Recruiting Oy

Pete & Patricia Dlugosh

Peter and Georgia Angelos

Peter B. Lambert

Peter Carton

Peter Debany

Peter F. Smith

Peter Horbury

Peter J. Lawrence

Peter M. Tutrani IRA

Peter Moore

Peter O. Raudaskoski

Phillip P. Edlin

Phillip R. Adams

Phillip Sgobba

Plastic Surgery Medical Clinic of San Diego

Prasad V. Gade

Productos Ecological De Mexico

Prof. Dr. Hannes Schierle

Proprete Investissement, Inc.

Proteus Global Ventures, LP

Quentin Rosas

 

 

R. Christopher Barczewski

R. Merrel Olesen, M.D.

R. Merrel Olesen, M.D., APC, MPPP

Rainer Burkhardt

Rainer Marxer

Rainer Mattes

Raj Wickramasekaran

Rakesh Aggarwal

Ralph Gitz

Ramin Ghassemi & Nina Mojaver

Randal Howard

Randall Moreadith

Raptor Fund, a Revocable Separate Property Trust

Ray Fadich

Raymond A. Bartolacci, III

Raymond Bartolacci, Jr.

Rees Orland

Rene Kreis

Respolar Oy

Rhoda Narins, MD

Richard & Betsy Fitzpatrick Family Trust

Richard & Deborah Fildes

Richard & Judy Fitzgerald JTWROS, Dr.

Richard Cardinale

Richard Clack

Richard E. Feinberg & Diane Gotkin

Richard Ernest

Richard M. Bodor, M.D.

Richard Salomone

Richard W. Cunningham

Riyadh Taila

Robert & Louis Giardina JTWROS

Robert Anderson

Robert Belfi Trust

Robert Brandt

Robert Caduff

Robert Dagosta

Robert Devere

Robert E. Duke

Robert E. Irelan

Robert Giardina and Eric Bonanno

Robert J. Des Marais

Robert J. Lange

Robert J. Mirabile

Robert Kearney, MD

 

 

Robert LoRusso

Robert Marvin

Robert McEntire

Robert Mega

Robert Petrozzo

Robert Schaefer

Robert Steel

Roberta Wieman

ROBHO Properties Inc.

Rodney Moser

Roger J. & M. Jenai Sullivan Wall

Roger Monteforte

Rohan Dhiman

Rolf Schierl

Rolf Steiner

Ron A. & Janet E. Rasch

Ronald & Mary Doubt

Ronald E. White

Ronald H. Medak

Ronald Harvard Medak

Ross Person

Rudolf Doessegger

Rullan Family Trust

Rupert Hourand, Dr.

Russell Cody

Russell S. Gold

Russell S. Gold Ph.D. Profit Sharing Plan

Rusti Bartell-Weiss

Ruth A Fair Trust

Ruth A. Stolzenberg

Sabine Geser

Saied & Pamela Motevasselani

Sal Furnari

Sammie R. & Carol L. Ford

Sandeep Gupta

Sandford Wilk

Sandra Bennemann

Sandra Tyrholm Trust

Sanfurd G. Bluestein

Sassan Alavi

Satbir Singh

Schneider Family Trust Dtd 9-1-83

Scot B. Jones

Scott Apperson, Richard Bodor & Meyer Tenenhaus

Scott Evan Olesen Irrevocable 2005 Trust

 

 

Scott Frey

Sean J. Suydam

Sean Loghman

Sebastian D’amico

Seymour Lippman IRA

Shahab Hillyer & Siamak Kalhor

Shari Joyce

Sharon Crowder

Shawn & Noushin Bagheri

Shawn Bagheri

Sheldon & Marjorie Derezin

Shelley J. Tauber

Shephard Bentley

Shuja Ahmed & Anthin Zito

Siamak Aghamohammadi

Sidney & Helene Silberman

Simin Siddiq, Dr.

Sorrento Drive Enterprises Inc.

South Bay Skin & Cancer Pension Plan For Dr. Peter Rullan

Spartan Marketing Ltd.

SSE Taylor Partners, LLC

St. Croix Capital Corporation Pension Plan

Stanley & Leigh Jensen

Stanley & Mary Coniglio

Stanley F. Roth, M.D.

Steen Allan Christensen

Stefan Brunner

Stefan Lemperle

Stefan Widensohler

Stephanie Carter

Stephen A. Geppi & Melinda C. Geppi

Stephen and Martha Kitchens

Stephen and Sharon Burke

Stephen Jones

Stevan F. Schweighardt

Steve & Mandy Romanelli

Steve Celotto

Steven Cohen, MD

Steven Markowitz

Steven Parkes

Stout, Uxa, Buyan & Mullins, LLP

STR Capital Securities Inc.

Stuart A. Teper

Stuart A. Young

Susan A. Thalken

 

 

Susan Ann Westre

Susan L. Wedell

Sutro V, LLC

Suzanne C. Bodor, M.D.

Suzette T. Seigel

Syed Fazal And Sumrana S. Ahmed

Tariq Muhammad

Taylor Family Trust, The

Terence Rhone

Terri C. Swanston IRA

Terry Sullivan Ira

Theo Juetz

Theodore L. Folkerth MD

Thomas & Jill Dizio

Thomas Baumann

Thomas C. Humes

Thomas C. Reiner

Thomas Christian

Thomas H. Cruikshank

Thomas Jeffery Kelley

Thomas L. Jones

Thomas Nutter & Shervin Yazdan

Thomas R. Farrell, MD

Thomas R. Vecchione

Thomas Tellez

Thomas W. Haydon

Thomas Weppelmann

Thunderbird Trust

Tim Callan

Tim Parkes

Timothy G. Canty Sr., Md Defined Benefit Pension Plan 1-1-84

Timothy J. Turner

Timothy Joseph Defined Pension Plan

Todd M. Peterson

Todriefield Ltd.

Tom Clotfelter

Tom Holly

Tom Slazinski

Total Maintenance Solutions Inc.

Tracy Fitzer

Tracy Howell

Transpro Property & Casualty Insurance Corp.

Trevor Callan

Tsewang Nyendak

Turner & Rosemary Daniels

 

 

Ubs (Luxembourg) S.A.

Urs — Peter Inderbitzin

Urs W Schmid

Urs-Peter Inderbitzin

Vera G. Gittes Revocable Trust

Vernon W. Schoemaker

Victor Hochberg

Victor Prieto Ira

Vincent Chierra

Vincent Latour

Vincent Vitale

Vita Pure

Wade Harb

Wade Harb & Elham S. Harb Jtwros

Walter And Lynda Cekala

Walter Carney

Walter E. & Tamara L. Novick

Walter H. Hickel

Walter Ruegg

Walter Wichern, Dr.

Warner C. Lusardi Family Trust Dated June 11, 1993

WB Partners

Webb Family Trust, U/A 9/20/99

Wells Family Trust

Wendelin Acker

WFS Consulting

William & Susan Boardman As Tenants By The Entirety

William A. Simms

William Burnett

William C. Stonhaus or Karen Stonhaus

William Howe

William J. Dixon

William Kirkpatrick

William M. Flynn, M.D.

William Mega

William P. Monahan

William Raventos

William S. Leavy

William S. Worrell

William Seare

William Wustenberg, DVM

Wolfgang Jakob

Wolfram Schmid

Woo, Jae Hoon

World Marketing Corp Profit Sharing Plan

 

 

Yong Ok Yi

Yvonne & Ole C. Olesen, Husband & Wife, as Joint Tenants

Zane Thomas Courbay

Zohreh Alaghemand

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