Document:

<PAGE>   1

                                                                    Exhibit 10.4

                              EMPLOYMENT AGREEMENT

                  THIS EMPLOYMENT AGREEMENT (this "Agreement"), dated as of
November 10, 1999, is by and between NetGenics, Inc , a Delaware corporation
(the "Company"), and Vincent P. Kazmer ("Executive").

                  In consideration of their mutual promises, agreements and
covenants and subject to the terms and conditions hereinafter set forth, the
Company and Executive hereby agree as follows:

                  1. POSITION; DUTIES; COMPENSATION. (A) Beginning on December
1, 1999, the Company shall employ Executive in the position of Executive Vice
President and Chief Financial Officer on an at-will basis, and Executive accepts
such employment on the terms and conditions hereinafter set forth During his
employment, Executive shall devote his entire business time and all reasonable
efforts to his employment, shall perform diligently such duties as are
customarily performed by the Chief Financial Officer of a company the size and
structure of the Company, and shall perform diligently such other duties as may
be assigned from time to time.

                           (B) In consideration for the services to be rendered
by Executive pursuant to this Agreement, the Company shall pay Executive at a
rate of One Hundred and Sixty Thousand dollars ($160,000) per year during the
first year of this Agreement. For any subsequent years of this Agreement,
Executive's salary rate shall be subject to annual review. Executive's salary
shall be payable to Executive in accordance with the Company's regular payroll
practices applicable to senior management personnel.

                           (C) If Executive is on the company's payroll as an
employee on August 1 of any year including 2000 and after, Executive shall be
entitled to additional compensation in the amount of $20,000, paid in a lump
sum.

                  2. BENEFITS; EXPENSES. Executive shall be entitled to take
three (3) weeks of vacation during each year of this Agreement, to be taken at
such times as the parties mutually agree. Unless otherwise specified in this
Section, the Company shall provide Executive with the same level of other
benefits (such as health insurance, life insurance, 401(k)) provided by the
Company from time to time to its other personnel.

                  3. STOCK OPTIONS. Subject to approval by the Directors of the
Company, Executive shall receive options to purchase 185,000 shares of the
Company under the Company's 1996 Stock Option Plan, a copy of which is attached
hereto.

                           Subject to approval by the Directors of the Company,
Executive shall be able to earn additional performance stock options based on
achievement of personal and company milestones or objectives as set by and as
determined by the Company.

                  4. TERMINATION Executive may terminate his employment at any
time by giving to the Company no less than one (1) month or more than two (2)
months' prior written notice. In the event Executive gives such notice, the
Company may, at its option, immediately discontinue Executive's duties. In such
event, however, the Company shall be obliged to continue Executive's salary and
benefits until the date of termination specified in Executive's notice.
Thereafter, Executive will have no right to further payments or to participate
in Company benefit plans, except as required by state or federal law.

<PAGE>   2

                  The Company may terminate Executive's employment at any time
without cause. In the event of such termination, the Company will continue
Executive's salary, but not any benefits (except if required by law) or bonus or
bonus payout, for twelve (12) months from the date of termination. In such
event, such payments will be at the same rate as prior to termination. In the
event Executive is discharged for cause, Executive's salary and benefits shall
not be continued for any period after discharge, except as required by state or
federal law (e.g., COBRA). For purposes of this Agreement, "cause" means
Executive's committing of any felony or other crime involving dishonesty or
moral turpitude, Executive's serious misconduct in the course of employment,
Executive's violation of Company policy, or Executive's repeated neglect of
duties (other than on account of incapacity).

                  5. CONFIDENTIAL AND PROPRIETARY INFORMATION. Executive shall
sign, and hereby agrees to be bound by, the NetGenics, Inc. "Confidentiality and
Non-Competition Agreement," which is incorporated herein by reference.

                  6. ARBITRATION. Any dispute arising under this Agreement, or
in the interpretation of this Agreement, or from Executive's employment or
ending of such employment, shall be resolved by submission to the American
Arbitration Association pursuant to the AAA's rules relating to the resolution
and determination of such disputes. In rendering his or her decision, the
arbitrator shall be bound by the principle that Executive has only those
contractual rights specifically enumerated in this Agreement, and that Executive
is otherwise an employee-at-will.

                  7. RELOCATION EXPENSES. Executive shall be entitled to
reimbursement for moving expenses of up to $2,000 incurred in relocating his
personal and household possessions from Houston, Texas to Hudson Ohio Before
being reimbursed or paid, Executive shall be required to present suitable
documentation of these expenses and/or claimed tax effects.

                  8. ENTIRE AGREEMENT; MODIFICATIONS. This Agreement supersedes
all previous agreements, arrangements and understandings, written or oral,
between Executive and the Company with respect to the subject matter hereof. No
modification, waiver, amendment or addition to any of the terms of this
Agreement shall be effective unless set forth in a writing signed by Executive
and the Company.

                  9. SEVERABILITY. All provisions contained in this Agreement
are severable, and in the event that any one of them shall be held to be invalid
by any court of competent jurisdiction, this Agreement shall be interpreted as
if such provision was not contained herein, and such determination shall not
otherwise affect the validity of any other provision.

                  10. GOVERNING LAW; VENUE. This Agreement shall be governed by
and construed in accordance with the laws of the State of Ohio, without regard
to any such laws relating to choice or conflict of laws.

                  11. COUNTERPARTS. This Agreement may be executed in multiple
counterparts, each of which shall be considered an original, but all of which
shall constitute one and the same instrument.

                  IN WITNESS WHEREOF, Executive and the Company, having read and
fully understood each of the foregoing provisions, have executed this Agreement
as of the date first set forth above.

<PAGE>   3
                            EXECUTIVE:

                            /s/ Vincent P. Kazmer
                            ----------------------------------------------------
                            EXECUTIVE: Vincent P. Kazmer

                            COMPANY:

                            NETGENICS, INC.

                            By: /s/ Manuel J. Glynias
                                ------------------------------------------------
                            Name: Manuel J. Glynias

                            Title: President and CEO<PAGE>   1
                                                                    Exhibit 10.5

[IBM LOGO]

TECHNICAL SERVICES AGREEMENT

AGREEMENT NUMBER # 1999-10

This Agreement dated as of October 15, 1999 ("EFFECTIVE DATE"), between
International Business Machines Corporation ("BUYER") and NetGenics, Inc.
("SUPPLIER"), establishes the basis for a multinational procurement relationship
under which Supplier will provide Buyer the Deliverables and Services described
in SOWs issued under this Agreement.

1.0  DEFINITIONS:

"AFFILIATES" means entities that control, are controlled by, or are under common
control with a party to this Agreement and that have signed a PA.

"AGREEMENT" means this agreement and any relevant Statements of Work ("SOW"),
Work Authorizations ("WA"), Participation Attachments ("PA"), and other
attachments or appendices specifically referenced in this Agreement.

"APPEARANCE DESIGN" means the appearance presented by an object, formed in
hardware or by software, that creates a visual impression on an observer.
Appearance Design refers to the ornamental and not the functional aspects of the
object.

"BUYER" means either IBM or one of its Affiliates which purchases or licenses
Deliverables or Services under this Agreement.

"BUYER PERSONNEL" means agents, employees, contractors or remarketers engaged by
Buyer.

"DELIVERABLE" means any item that Supplier prepares for or provides to Buyer as
described in a SOW. Deliverables include Developed Works, Preexisting Materials,
and Tools.

"DERIVATIVE WORK" means a work that is based on an underlying work and that
would be a copyright infringement if prepared without the authorization of the
copyright owner of the underlying work.

"DEVELOPED WORKS" means Deliverables including their Externals, developed in the
performance of this Agreement that Buyer will own, and does not include
Preexisting Materials, Tools, or items specifically excluded in a SOW.

"EXTERNALS" means any pictorial, graphic, or audiovisual works generated by
execution of code and any programming interfaces, languages or protocols
implemented in code to enable interaction with other computer programs or end
users. Externals do not include the code that implements them.

"INVENTION" means any idea, design, concept, technique, invention, discovery or
improvement, whether or not patentable, conceived or reduced to practice by
Supplier or Supplier Personnel in performance of this Agreement.

"JOINT INVENTION" means any Invention made by Supplier or Supplier Personnel
with Buyer Personnel.

"PARTICIPATION ATTACHMENT" or "PA" means an attachment to this Agreement which
evidences the signing Affiliate's intent to conduct transactions, if any, in
accordance with this Agreement.

"PREEXISTING MATERIALS" means items including their Externals, contained within
a Deliverable, in which the copyrights are owned by Supplier prepared or that
were prepared outside the scope of this Agreement. Preexisting Materials exclude
Tools, but may include material that is created by the use of Tools.

                                  Page 1 of 6
<PAGE>   2

"PRICES" means the agreed upon prices and currency for Deliverables and
Services, including all applicable fees, royalty payments and taxes, as
specified in the relevant SOW.

"SERVICES" means the services identified in the relevant SOW.

"STATEMENT OF WORK" or "SOW" means any document attached to or included in this
Agreement which describes the Deliverables and Services, including any
requirements, specifications or schedules.

"SUPPLIER" means either Supplier or one of its Affiliates.

"SUPPLIER PERSONNEL" means agents, employees or subcontractors engaged by
Supplier.

"TOOLS" means not commercially available software, and their Externals, required
for the development, maintenance or implementation of a software Deliverable.

"WORK AUTHORIZATION" or "WA" means a purchase order or other Buyer designated
document, such as a Work Order, in either electronic or hard copy form, issued
by Buyer's procurement personnel, and is the only authorization for Supplier to
perform any work under this Agreement. A SOW is a WA only if designated as such
in writing by Buyer.

2.0 STATEMENT OF WORK: Supplier will provide Deliverables and Services as
specified in the relevant SOW only when specified in a WA. Supplier will begin
work only after receiving written authorization from Buyer. Buyer may request
changes to a SOW and Supplier will submit to Buyer the impact of such changes.
Changes accepted by Buyer will be specified in an amended SOW or change order
signed by both parties.

3.0  TERM AND TERMINATION

   3.1 TERM: Deliverables and Services acquired by Buyer on or after the
Effective Date will be covered by this Agreement. This Agreement will remain in
effect until terminated.

   3.2 TERMINATION OF THIS AGREEMENT: Either party may terminate this Agreement,
without any cancellation charge, for a material breach of the Agreement by the
other party or if the other party becomes insolvent or files or has filed
against it a petition in bankruptcy ("Cause"), to the extent permitted by law.
Such termination will be effective at the end of a thirty (30) day written
notice period if the Cause remains UNCURED. Either party may terminate this
Agreement without Cause when there are no outstanding SOWs.

 3.3 TERMINATION OF A SOW OR WA: Buyer may terminate a SOW or a WA with or
without Cause. Upon termination, in accordance with Buyer's written direction,
Supplier will immediately: (i) cease work; (ii) prepare and submit to Buyer an
itemization of all completed and partially completed Deliverables and Services;
(iii) deliver to Buyer Deliverables satisfactorily completed up to the date of
termination at the agreed upon Prices in the relevant SOW; and (iv) deliver upon
request any work in process. In the event Buyer terminates without Cause, Buyer
will compensate Supplier for the actual and reasonable expenses incurred by
Supplier for work in process up to and including the date of termination,
provided such expenses do not exceed the Prices.

4.0  PRICING

   4.1 PRICING: Supplier will provide Deliverables and Services to Buyer for the
Prices. Except for pre-approved expenses specified in the relevant SOW, the
Prices for Deliverables and Services specified in a WA and accepted by Buyer
will be the only amount due to Supplier from Buyer.

   4.2 COMPETITIVE PRICING: If Supplier offers lower prices to another customer
for like or lesser quantities of Deliverables or Services during the same period
and under similar terms and conditions as Buyer, those prices will be made known
and available to Buyer at the time of their availability to the customer. Prices
will at least be competitive with industry prices and, if not, Supplier will use
reasonable efforts to adjust its Prices so that they are competitive.

5.0 PAYMENTS AND ACCEPTANCE: Terms for payment will be specified in the relevant
SOW or WA. Payment of invoices will not be deemed acceptance of Deliverables or
Services, but rather such Deliverables or Services will be subject to
inspection, test and rejection in accordance with the acceptance or completion
criteria as specified in the relevant SOW. Buyer may, at its option, either
reject Deliverables or Services that do not comply with the acceptance or
completion criteria for a refund, or require Supplier, upon Buyer's written
instruction, to repair or replace such Deliverables or re-perform such Service,
without charge and in a timely manner.

                                  Page 2 of 6

<PAGE>   3

6.0  WARRANTIES

   6.1 ONGOING WARRANTIES: For a period of three (3) years from the completion
of any SOW under this Agreement, Supplier makes the following ongoing
representations and warranties: (i) it has the right to enter into this
Agreement and its performance of this Agreement will not violate the terms of
any contract, obligation, law, regulation or ordinance to which it is or becomes
subject; (ii) no claim, lien, or action exists or is threatened against Supplier
that would interfere with Buyer's rights under this Agreement; (iii)
Deliverables are safe for any use consistent with and will comply with the
warranties, specifications and requirements in this Agreement; (iv) Services
will be performed using reasonable care and skill and in accordance with the
relevant SOW; (v) Deliverables and Services are Year 2000 ready such that they
are capable of correctly processing, providing, receiving and displaying date
data, as well as exchanging accurate date data with all products with which the
Deliverables or Services are intended to be used within and between the
twentieth and twenty-first centuries so long as any and all IBM hardware or
software provided by Buyer which exchanges date data with the Deliverables are
also Year 2000 ready as defined in this sub-paragraph; and provided that, with
respect to third party hardware and software, such hardware and software
properly exchanges date data with Supplier's Deliverable and Services (vi)
Deliverables will be tested for, and do not contain, harmful code; (vii)
Deliverables and Services do not infringe any privacy, publicity, reputation or
intellectual property right of a third party; and (viii) all authors have agreed
not to assert their moral rights (personal rights associated with authorship of
a work under applicable law) in the Deliverables, to the extent permitted by
law.

THE WARRANTIES AND CONDITIONS IN THIS AGREEMENT ARE IN LIEU OF ALL OTHER
WARRANTIES AND CONDITIONS, EXPRESS OR IMPLIED, INCLUDING THE IMPLIED WARRANTIES
OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

   6.2 WARRANTY REDEMPTION: If Deliverables or Services do not comply with the
warranties in this Agreement, Supplier will repair or replace Deliverables or
re-perform Services, without charge and in a timely manner. If Supplier fails to
do so, Buyer may repair or replace Deliverables or re-perform Services and
Supplier will reimburse Buyer for actual and reasonable expenses.

7.0 DELIVERY: Deliverables or Services will be delivered as specified in the
relevant SOW. If Supplier cannot comply with a delivery commitment, Supplier
will promptly notify Buyer of a revised delivery date and Buyer may: (i) cancel
without charge Deliverables or Services not yet delivered; (ii) procure such
Deliverables or Services elsewhere and charge Supplier the cost differential;
and (iii) exercise all other remedies provided at law, in equity and in this
Agreement.

8.0  INTELLECTUAL PROPERTY

   8.1 WORK MADE FOR HIRE: All Developed Works belong exclusively to Buyer and
are works made for hire. If any Developed Works are not considered works made
for hire owned by Buyer by operation of law, Supplier assigns the ownership of
copyrights in such works to Buyer. SUPPLIER WILL HAVE NO LICENSE OR OTHER RIGHTS
IN THE DEVELOPED WORKS DELIVERED PURSUANT TO THE AGREEMENT. IF BUYER
DISCONTINUES DEVELOPING AND MARKETING OF THE SOLUTION RELATED TO THE DEVELOPED
WORKS, BUYER AGREES TO ENTER INTO GOOD FAITH NEGOTIATIONS TO LICENSE THE
DEVELOPED WORKS TO NETGENICS UNDER REASONABLE AND MUTUALLY AGREEABLE TERMS AND
CONDITIONS.

   8.2 PREEXISTING MATERIALS: Neither Party will include any Preexisting
Materials in any Deliverable unless they are listed in the relevant SOW or WA.
Prior to including any Preexisting Materials that contain copyrights , patents
or other intellectual property rights owned by third parties, the party
proposing to use third party materials shall notify the other party of such
Preexisting Materials, and the parties shall determine whether existing third
party licenses and any other intellectual property rights are adequate to use
such third party copyrighted materials as required under the WA. Neither party
will use such third party materials unless and until the parties agree that the
third party's license or other rights provided are adequate for the intended use
by the parties, the Customers, or other relevant third parties. Supplier grants
Buyer a nonexclusive, worldwide, perpetual, irrevocable, paid-up, license to
prepare and have prepared Derivative Works of Preexisting Materials and to use,
have used, execute, reproduce, transmit, display, perform, transfer, distribute,
and sublicense Preexisting Materials or their Derivative Works. The rights and
licenses granted by Supplier to Buyer under this Subsection include the right of
Buyer to authorize or sublicense others to exercise any of the rights granted to
Buyer in this Subsection.

   8.3 TOOLS: Supplier will not include Tools in Deliverables unless they are
listed in the relevant SOW. Supplier grants Buyer a nonexclusive, worldwide,
perpetual, irrevocable, paid-up, license to prepare and have prepared Derivative
Works of Tools, and to use, have used, execute, reproduce, transmit, display and
perform Tools or their Derivative Works.

                                  Page 3 of 6

<PAGE>   4

   8.4 INVENTION RIGHTS: Supplier will promptly provide to Buyer a complete
written disclosure for each Invention which identifies the features or concepts
which Supplier believes to be new or different. Inventions are owned by
Supplier, except for Joint Inventions and Inventions relating to an Appearance
Design. Supplier grants to Buyer an irrevocable, nonexclusive, worldwide,
paid-up license under these Inventions (including any patent applications filed
on or patents issued claiming Inventions). The license scope is to make, have
made, use, have used, sell, license or transfer items and to practice and have
practiced methods. Supplier assigns to Buyer all Inventions, and patents issuing
on them, relating to an Appearance Design.

   8.5 JOINT INVENTION RIGHTS: The parties will jointly own all Joint Inventions
and resulting patents. Either party may license others under Joint Inventions
(including any patent applications filed on or patents issued claiming Joint
Inventions) without accounting to or consent from the other.

   8.6 PERFECTION OF COPYRIGHTS: Upon request, Supplier will provide to Buyer a
"Certificate of Originality" or equivalent documentation to verify authorship of
Deliverables. Supplier will confirm assignment of copyright for Developed Works
using the "Confirmation of Assignment of Copyright" form and will assist Buyer
in perfecting such copyrights. Supplier will be responsible for registration,
maintenance and enforcement of copyrights for Preexisting Materials. If Supplier
does not register a copyright in Preexisting Materials, Supplier authorizes
Buyer to act as its agent in the copyright registration of such Preexisting
Materials.

   8.7 PERFECTION OF INVENTION RIGHTS: Supplier will identify all countries in
which it will seek patent protection for each Invention. Supplier authorizes
Buyer to act as its agent in obtaining patent protection for the Inventions in
countries where Supplier does not seek patent protection. Supplier will, at
Buyer's expense, assist in the filing of patent applications on Inventions and
have required documents signed.

   8.8 TRADEMARKS: This Agreement does not grant either party the right to use
the other party's trademarks, trade names or service marks.

9.0  INDEMNIFICATION

   9.1 GENERAL INDEMNIFICATION: Supplier will defend, hold harmless and
indemnify, including attorney's fees, Buyer and Buyer Personnel against claims
that arise or are alleged to have arisen as a result of negligent or intentional
acts or omissions of Supplier or Supplier Personnel or breach by Supplier of any
term of this Agreement.

   9.2 INTELLECTUAL PROPERTY INDEMNIFICATION: Supplier will defend, or at
Buyer's option cooperate in the defense of, hold harmless and indemnify,
including attorney's fees, Buyer and Buyer Personnel from claims that Supplier's
Deliverables or Services infringe the intellectual property rights of a third
party. If such a claim is or is likely to be made, Supplier will, at its own
expense, exercise the first of the following remedies that is practicable: (i)
obtain for Buyer the right to continue to use, sell and license the Deliverables
and Services consistent with this Agreement; (ii) modify Deliverables and
Services so they are non-infringing and in compliance with this Agreement; (iii)
replace the Deliverables and Services with non-infringing ones that comply with
this Agreement; or (iv) at Buyer's request, accept the cancellation of
infringing Services and the return of infringing Deliverables and refund any
amount paid.

   9.3 EXCEPTIONS TO INDEMNIFICATION: Supplier will have no obligation to
indemnify Buyer or Buyer Personnel for claims that Supplier's Deliverables or
Services infringe the intellectual property rights of a third party to the
extent such claims arise as a result of: (i) Buyer's combination of Deliverables
or Services with other products or services not reasonably expected by Supplier;
(ii) Supplier's implementation of a Buyer originated design; or (iii) Buyer's
modification of the Deliverables.

10.0 LIMITATION OF LIABILITY: Except for liability under the Section entitled
Indemnification, in no event will either party be liable to the other for any
lost revenues, lost profits, incidental, indirect, consequential, special or
punitive damages.

11.0 SUPPLIER AND SUPPLIER PERSONNEL: Supplier is an independent contractor and
this Agreement does not create an agency relationship between Buyer and Supplier
or Buyer and Supplier Personnel. Buyer assumes no liability or responsibility
for Supplier Personnel. Supplier will: (i) ensure it and Supplier Personnel are
in compliance with all laws, regulations, ordinances, and licensing
requirements; (ii) be responsible for the supervision, control, compensation,
withholdings, health and safety of Supplier Personnel; (iii) ensure Supplier
Personnel performing Services on Buyer's premises comply with the On Premises
Guidelines; and (iv) inform Buyer if a former employee of Buyer will be assigned
work under this Agreement, such assignment subject to Buyer approval.

12.0 ELECTRONIC COMMERCE: Supplier will use best efforts to participate in
Electronic Data Interchange ("EDI") or other electronic commerce approach, under
which the parties will electronically transmit and receive legally binding
purchase and sale obligations ("Documents"), including electronic credit entries
transmitted by Buyer to the Supplier

                                  Page 4 of 6

<PAGE>   5

account specified in the relevant SOW. Each party, at its own expense, will
provide and maintain the equipment, software, services and testing necessary for
it to effectively and reliably transmit and receive such Documents. Either party
may use a third party service provider for network services, provided the other
party is given sixty (60) days prior written notice of any changes to such
services. A Document will be deemed received upon arrival at the receiving
party's mailbox or Internet address and the receiving party will promptly send
an acknowledgment of such receipt. The receiving party will promptly notify the
originating party if a Document is received in an unintelligible form, provided
that the originating party can be identified. In the absence of such notice, the
originating party's record of the contents of such Document will prevail. Each
party will authenticate Documents using a digital signature or User ID, as
specified by Buyer, and will maintain security procedures to prevent its
unauthorized use.

13.0 RECORDKEEPING AND AUDIT RIGHTS: Supplier will maintain (and provide to
Buyer upon request) relevant accounting records to support invoices under this
Agreement and proof of required permits and professional licenses, for three (3)
years following completion or termination of the relevant SOW. All accounting
records will be maintained in accordance with generally accepted accounting
principles.

14.0  GENERAL

   14.1 AMENDMENTS: This Agreement may only be amended by a writing specifically
referencing this Agreement which has been signed by authorized representatives
of the parties.

   14.2 ASSIGNMENT: Neither party will assign their rights or delegate or
subcontract their duties under this Agreement to third parties or affiliates
without the prior written consent of the other party, such consent not to be
withheld unreasonably, except that Buyer may assign this Agreement in
conjunction with the sale of a substantial part of its business utilizing this
Agreement or any intellectual property assigned or licensed under this
Agreement. Any unauthorized assignment of this Agreement is void.

   14.3 CHOICE OF LAW AND FORUM; WAIVER OF JURY TRIAL; LIMITATION OF ACTION:
This Agreement and the performance of transactions under this Agreement will be
governed by the laws of the country in which the transaction is performed,
except that the laws of the State of New York applicable to contracts executed
in and performed entirely within that State will apply if any part of the
transaction is performed within the United States. The United Nations Convention
on Contracts for the International Sale of Goods does not apply. The parties
expressly waive any right to a jury trial regarding disputes related to this
Agreement. Unless otherwise provided by local law without the possibility of
contractual waiver or limitation, any legal or other action related to a breach
of this Agreement must be commenced no later than two (2) years from the date of
the breach in a court sited within the country in which the breach occurred, or
in a court sited in the State of New York if any part of the transaction is
performed within the United States.

   14.4 COMMUNICATIONS: All communications between the parties regarding this
Agreement will be conducted through the parties' representatives as specified in
the relevant SOW.

   14.5 COUNTERPARTS: This Agreement may be signed in one or more counterparts,
each of which will be deemed to be an original and all of which when taken
together will constitute the same agreement. Any copy of this Agreement made by
reliable means is considered an original.

   14.6 EXCHANGE OF INFORMATION: Unless required otherwise by law, all
information exchanged by the parties will be considered non-confidential. If the
parties require the exchange of confidential information, such exchange will be
made under a confidentiality agreement. The parties will not publicize the terms
or conditions of this Agreement in any advertising, marketing or promotional
materials except as may be required by law, provided the party publicizing
obtains any confidentiality treatment available. Supplier will use information
regarding this Agreement only in the performance of this Agreement.

   14.7 FREEDOM OF ACTION: This Agreement is nonexclusive and either party may
design, develop, manufacture, acquire or market competitive products or
services. Buyer will independently establish prices for resale of Deliverables
or Services and is not obligated to announce or market any Deliverables or
Services and does not guarantee the success of its marketing efforts, if any.

   14.8 FORCE MAJEURE: Neither party will be in default or liable for any delay
or failure to comply with this Agreement due to any act beyond the control of
the affected party, excluding labor disputes, provided such party immediately
notifies the other.

   14.9 OBLIGATIONS OF AFFILIATES: Affiliates will acknowledge acceptance of the
terms and conditions of this Agreement through the signing of a PA before
conducting any transaction under this Agreement.

                                  Page 5 of 6
<PAGE>   6

   14.10 PRIOR COMMUNICATIONS AND ORDER OF PRECEDENCE: This Agreement replaces
any prior oral or written agreements or other communication between the parties
with respect to the subject matter of this Agreement, excluding any confidential
disclosure agreements. In the event of any conflict in these documents, the
order of precedence will be: (i) the quantity, payment and delivery terms of the
relevant WA; (ii) the relevant SOW; (iii) the relevant PA; (iv) this agreement;
and (v) the remaining terms of the relevant WA.

   14.11 SEVERABILITY: If any term in this Agreement is found by competent
judicial authority to be unenforceable in any respect, the validity of the
remainder of this Agreement will be unaffected, provided that such
unenforceability does not materially affect the parties' rights under this
Agreement.

   14.12 SURVIVAL: The provisions set forth in the following Sections and
Subsections of this Agreement will survive after termination of this Agreement
and will remain in effect until fulfilled: "Ongoing Warranties", "Intellectual
Property", "Indemnification", "Limitation of Liability", "Record Keeping and
Audit Rights", "Choice of Law and Forum; Waiver of Jury Trial; Limitation of
Action", "Exchange of Information", and "Prior Communications and Order of
Precedence".

   14.13 WAIVER: An effective waiver under this Agreement must be in writing
signed by the party waiving its right. A waiver by either party of any instance
of the other party's noncompliance with any obligation or responsibility under
this Agreement will not be deemed a waiver of subsequent instances.

    14.14 PUBLICITY: There shall be no publicity of any kind regarding the
Agreement by either Party without the prior written consent of the other.

ACCEPTED AND AGREED TO:

IBM CORPORATION

By /s/ Daniel P. McCurdy          10/19/99
   ----------------------------------------
Authorized Signature                Date

Daniel P. McCurdy

Vice President, Life Sciences,  IBM Corporation

ACCEPTED AND AGREED TO:

NETGENICS, INC.

By /s/ Manuel J. Glynias
   ----------------------------------------
Authorized Signature                Date

Manuel J. Glynias

President and Chief Executive Officer,  NetGenics, Inc.

                                  Page 6 of 6

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