Document:

Employment Agreement between the Registrant and Stanley D. Rose

 Exhibit 10.15 
 NimbleGen Systems Inc. 
 One Science Court 
 Madison, WI 53711 
 September 9, 2003 
 Dr. Stanley Rose 
 P.O. Box 1645 
 St. John, USVI 00831 
 Dear Stan: 
 This letter will confirm our agreement with respect to the terms of your employment by NimbleGen Systems Inc. (the “Company”). We have agreed
as follows: 
 1. Term of Employment and Duties. You will be employed by the Company on a part-time basis as the President and Chief
Executive Officer of the Company starting on September 9, 2003, and continuing until your employment is terminated as a result of your death or pursuant to Paragraph 11 below. During the term of your employment, you agree to devote your best
efforts and skills and at least one-half of the business time and attention that normally would be associated with a full-time chief executive officer position to the business and affairs of the Company. Subject to this minimum time commitment, the
amount of time you devote to the business and affairs of the Company will be at your discretion. 
 2. Compensation. In consideration
of your services to the Company: 
 (a) During the term of your employment, the Company will pay you a salary at the per diem
rate of One Thousand Two Hundred Fifty and No/100 Dollars ($1,250.00) for each full day of service to the Company and Six Hundred Twenty-Five and No/100 Dollars ($625.00) for each half day of service, payable according to the regular payroll
practices of the Company. In addition, you may be eligible for bonus compensation in the discretion of the Board of Directors of the Company. 
 (b) Effective as of the execution and delivery of this agreement, you have been granted an option to purchase 180,000 shares of the Company’s Common Stock on the terms set out in the Award Agreement between you
and the Company executed and delivered contemporaneously with this agreement. 
 3. Expenses and Benefits. 
 (a) The Company will pay or reimburse you for all reasonable expenses incurred by you in furtherance of the Company’s business,
subject to your compliance with the reimbursement guidelines of the Company in effect from time to time concerning expense reimbursements. These expenses include, but are not limited to, reasonable costs for travel by you to and from your office in
St. John to attend to Company business. 

 (b) During the term of your employment, you will be entitled to participate, on the same
terms and conditions as other senior employees of the Company, in any health insurance, disability insurance, life insurance, retirement, and other similar fringe benefit plans made available during your employment with the Company. You acknowledge
that you have no rights in any such plans except as expressly provided under the terms of such plans, including provisions establishing minimum hours or other eligibility requirements, and that such plans may be terminated, modified or supplemented
at any time. However, if you do not satisfy the eligibility requirements for participation in the health insurance plan, and you are not eligible to participate in the health insurance plan of another employer, the Company will pay the cost of any
personal health insurance policy carried by you (including coverage for your dependents who would be eligible for coverage under the Company’s health plan) up to a maximum of $1,250 per month. Notwithstanding the foregoing, given your part-time
status, you will not be eligible to participate in the Company’s vacation or sick leave plans. 
 (c) As a director and
officer of the Company, you will be provided with insurance coverage under the directors and officers liability insurance coverage maintained by the Company. 
 4. Company Acknowledgments. 
 (a) The Company acknowledges and agrees that you will
not be required to work full time for the Company and that you may, from time to time, provide consulting and/or other services to other entities, provided that such other engagements comport with your obligations set forth in this agreement.

 (b) The Company acknowledges and agrees that you will continue to remain active as a member of the Board of Directors of
Opgen, Inc. and that you may, in the future, be appointed to be a member of the Board of Directors of another company (or other companies), provided that such other appointments comport with your obligations set forth in this agreement. The Company
further agrees that it will not unreasonably interfere with your ability to serve on any such Boards. 
 5. Confidential Information.
You agree that: 
 (a) During the term of your employment with the Company, you will not directly or indirectly use or
disclose any Confidential Information or Trade Secret Information except in the interest of and for the benefit of the Company and/or any of its subsidiaries or successors in interest. After termination of your employment with the Company, you will
not directly or indirectly use or disclose any Trade Secret Information unless (i) you first secure written consent from the Company to such disclosure or use, (ii) the information ceases to be deemed a Trade Secret by means of one of the
exceptions set forth below, or (iii) you are ordered to disclose the same by a court of competent jurisdiction or are otherwise required to disclose the same by law, and you promptly notify the Company of such requirement. For two years
following the termination of your employment with the Company, you will not directly or indirectly use or disclose any Confidential Information unless (i) you first secure written consent of the Company to such disclosure or use, (ii) such
information ceases to be deemed Confidential Information by means of one of the exceptions set forth below, or (iii) you are ordered to disclose the same by a court of competent jurisdiction or are otherwise required to 

  

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disclose the same by law, and you promptly notify the Company of such disclosure. The term “Trade Secret” or “Trade Secret Information”
shall have that meaning set forth under Wisconsin law. The term “Confidential Information” shall mean all non-Trade Secret information of the Company or its subsidiaries which has value to the Company or its subsidiaries (whether or not in
written form) and which is not known to the public generally (absent your disclosure), including but not limited to any product or service offered or under development by the Company or its subsidiaries (including without limitation any technical
information, know-how, or manufacturing or engineering specifications, components or procedures) or any other confidential information regarding the business of the Company and its subsidiaries (including without limitation confidential knowledge,
operating instructions, competitive strategies , litigation files, customer lists, financial data, and personnel-related information). Notwithstanding the foregoing, the terms “Trade Secret Information,” “Trade Secret” and
“Confidential Information” shall not include, and the obligations set forth in this agreement shall not apply to, any information which (i) can be demonstrated by you to have been known by you prior to your employment by the Company,
(ii) is or becomes generally available to the public through no act or omission by you, (iii) is obtained by you in good faith from a third party who discloses such information to you on a non-confidential basis without violating any
obligation of confidentiality or secrecy relating to the information disclosed, or (iv) is independently developed by you outside the scope of your employment without use of Confidential Information or Trade Secrets. 
 (b) Upon the termination of your employment with the Company you will promptly surrender to the Company, or destroy and certify such
destruction to the Company, any documents, materials, or computer or other electronic records containing any Trade Secrets or Confidential Information which are in your possession or under your control. 
 6. Disclosure and Assignment of Inventions. You agree to disclose promptly and fully to the Company all inventions, improvements or discoveries
which relate to the businesses now conducted by the Company or which relate to any other business conducted by the Company in the future and during the term of your employment with the Company, made or conceived by you, solely or jointly with
others, whether or not developed on your own time or with the Company’s resources (“Company-Related Inventions”). All right, title and interest in and to any Company-Related Inventions will belong exclusively to the Company, and you
agree to execute and deliver whatever documentation may be requested by the Company to confirm such ownership. You also agree to provide reasonable assistance to the Company, upon its request and at its expense, (i) to obtain patents for any
Company-Related Inventions in any and all countries, and (ii) in any controversy or legal proceeding relating to any Company-Related Inventions, or to the patents resulting therefrom. Nothing in this paragraph, however, is intended to or shall
be deemed to limit, conflict with, or in any way alter any of your obligations to OpGen, Inc. pursuant to your obligations under the Non-Disclosure, Inventions and Non-Competition Agreement between you and OpGen, Inc., as currently in effect.

 7. Nonsolicitation of Employees. You agree that you will not, directly or indirectly, at any time during the term of your
employment by the Company, or during the one-year period following the termination of your employment with the Company, encourage any employee of the Company or its subsidiaries to terminate his or her employment with the Company or its 

  

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subsidiaries so as to accept employment elsewhere or to diminish or curtail the services such person provides to the Company and its subsidiaries.

 8. Noncompetition and Nonsolicitation of Customers. 
 (a) You agree that, during the term of your employment with the Company, and during the one-year period following the termination of your
employment with the Company, for whatever reason, you will not, without the prior written consent of the Company, accept employment in any managerial capacity or in any position involving the selling of products or services with, or directly or
indirectly consult with or provide advice or assistance in the areas of management, operations or sales to, any person or entity engaged in the business of developing, manufacturing or selling for gene expression or gene sequencing DNA microarrays
or related products or developing or providing microarray services or related products. 
 (b) You agree that: 
 (1) During the term of your employment with the Company, you will not, without the prior written consent of the Company, directly or
indirectly, divert or attempt to divert Customers’ business from the Company or its subsidiaries anywhere the Company or its subsidiaries does or is taking steps to do business. The term “Customer” shall mean any individual or entity
for whom/which the Company or its subsidiaries has provided services or products or made a proposal to perform services or provide products. 
 (2) During the one-year period following the termination of your employment with the Company, for whatever reason, you will not, directly or indirectly, solicit business from any Restricted Customer in any manner
which competes with products or services offered by the Company or its subsidiaries, or directly or indirectly divert or attempt to divert any Restricted Customer’s business from the Company or its subsidiaries. For purposes hereof, a
“Restricted Customer” is any individual or entity who/which meets both of the following conditions: (i) for whom or for which the Company or its subsidiaries provided products or services during the 24 months preceding the termination
of your employment and (ii) with whom and with which you had direct contact on behalf of the Company or its subsidiaries during the term of your employment with the Company and during the 24 months preceding the termination of your employment.

 9. Employee Acknowledgements and Disclosures. 
 (a) You recognize that irreparable and incalculable injury will result to the Company and its businesses and properties in the event of
your breach of any of the restrictions imposed by Paragraphs 5 through 8, above. You therefore agree that, in the event of any such actual, impending or threatened breach, the Company will be entitled, in addition to any other remedies and damages
available to it, to temporary and permanent injunctive relief (without the necessity of posting a bond or other security) restraining the violation, or further violation, of such restrictions by you and by any other person or entity from whom/which
you may be acting or who/which is acting for you or in concert with you. 
  

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 (b) You acknowledge and represent that the scope of the restrictions contained in this
agreement are appropriate, necessary and reasonable for the protection of the business, goodwill and property rights of the Company and its subsidiaries. You further acknowledge that the restrictions imposed will not prevent you from earning a
living in the event of, and after, the end of your employment with the Company for whatever reason. 
 (c) You confirm that
you are not subject to any contractual, statutory or other restrictions that you believe will conflict with or restrict your ability to perform the duties for which you are being hired as described in this agreement. Specifically, we acknowledge the
restrictions contained in the Non-Disclosure, Inventions and Non-Competition Agreement between you and OpGen, Inc., and the Consulting Agreement between you and Sention Inc., but you confirm your belief that these restrictions will not conflict with
or restrict your ability to perform the duties for which you are being hired as described in this agreement. While you are employed by the Company, we understand that you will comply with any restrictions to which you are subject under these
agreements. We also acknowledge that such conflicts could develop in the future because of changes in the business operations of the Company or the business operations of the companies in which you are or have been involved, and we acknowledge
receipt of your memorandum regarding potential future conflicts. 
 10. Board of Directors. For as long as you serve as the President
and Chief Executive Officer of the Company, the Company shall use its best efforts to ensure that you are appointed and maintained as, and you agree to serve as, a member of the Board of Directors of the Company. 
 11. Termination. Your employment by the Company is at will and may be terminated at any time by you or by the Company, for any reason or no
reason, upon written notice given by the party exercising such termination right to the other party. As a condition of the Company exercising its right under this provision, the Company will tender payment to you of all outstanding compensation then
due to you pursuant to this agreement. 
 12. Miscellaneous. 
 (a) This agreement and all questions of its interpretation, performance and enforcement and the rights and remedies of parties will be
determined in accordance with the laws of the State of Wisconsin without application of conflict of law principles. 
 (b) The
Company will deduct from the payments to be made to you under this agreement any federal, state or local withholding or other taxes or charges which the Company is from time to time required to deduct under applicable law, and all amounts payable to
you under this agreement are stated before any such deduction. 
 (c) This agreement supersedes any and all prior agreements,
whether written or oral, between the Company or any representative thereof and you relating to the services to be performed by you for the Company or your compensation for such services, and all such prior agreements are null and void. This
agreement also supersedes and replaces the Confidentiality Agreement between you and the Company dated April 25, 2002, which is null and void except to the extent of any rights arising under such agreement for a failure to comply with its terms
which exist as of the execution and delivery of this agreement. 
  

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 (d) This agreement may be amended or modified only in writing. 
 If this letter correctly sets forth your understanding of our agreement, please sign a copy in the space provided below and return it to the Company.

  

	
	Very truly yours,
	
	NIMBLEGEN SYSTEMS INC.
	
	/s/ Robert J. Palay
	Robert J. Palay
	Chairman of the Board of Directors

 I confirm my agreement with 
 the terms and conditions of this letter. 
  

	
	
	/s/ Stanley D. Rose
	Date: September 9, 2003

  

 6Employment Agreement between the Registrant and David S. Snyder

 Exhibit 10.16 
 NimbleGen Systems Inc. 
 One Science Court 
 Madison, WI 53711 
 September 18, 2006 
 Mr. David S. Snyder 
 1097 Ash Street 
 Winnetka, Illinois 60093 
 Dear Mr. Snyder: 
 This letter (when executed and delivered by you as contemplated below, “this Agreement”) will confirm terms and conditions of your employment
by NimbleGen Systems Inc. (the “Company”). They are as follows: 
 1. Term of Employment and Duties. 
 (a) Term. You are employed by the Company as its Chief Financial Officer. Your employment began on January 18, 2006 and shall
continue until terminated pursuant to Section 7 below. 
 (b) Employment Duties. 
 (i) During the term of your employment, you agree to devote your best efforts and all of your business time, attention and skill to the
business and affairs of the Company as required by its business needs. You will report directly to the Chief Executive Officer of the Company and you shall perform such duties as may be assigned to you from time to time by or under authority of the
Board of Directors of the Company (the “Board of Directors”) and/or the Chief Executive Officer of the Company, consistent with the foregoing. 
 (ii) Notwithstanding what is provided above in subparagraph 1(b)(i), you shall be permitted to engage in charitable and civic activities and to serve as a director of, or provide occasional consulting services
to, one or more other entities provided that such activities (individually and/or collectively) comport with your obligations set forth in this Agreement, do not interfere with the performance of your duties or responsibilities under this Agreement
and are not for the benefit of any business that the Board of Directors determines in good faith is or is seeking to become a competitor of the Company. You shall give the Chairman of the Board of Directors reasonable prior notice of all such
activities that you intend to engage in from time to time. 

 2. Compensation. 
 (a) Base Salary. During the term of your employment, the Company will pay you a salary at the rate of $16,666.67 per calendar
month, payable according to the regular payroll practices of the Company. 
 (b) Incentive Bonus. During the term of
your employment, in addition to the base salary as provided in subparagraph 2(a) above, annual bonuses may be paid to you from time to time based upon the attainment of individual and/or Company performance goals and objectives in the good
faith discretion of the Chief Executive Officer, the Board of Directors or its Compensation Committee. 
 (c) Withholding
and Other Taxes. The Company will deduct from the payments to be made to you under this Agreement any Federal, State or local withholding or other taxes or charges which the Company is from time to time required to deduct under applicable law,
and all amounts payable to you under this Agreement are stated before any such deduction. 
 (d) Equity. The Company
has granted you an option to purchase 60,000 shares of the Company’s Common Stock and 150,000 shares of the Company’s Series E Preferred Stock on the terms set out in the Award Agreement between you and the Company executed and delivered
contemporaneously with this Agreement. 
 3. Expenses and Benefits. 
 (a) Employee Expenses. The Company will pay or reimburse you for all reasonable automobile, travel, entertainment and like expenses
ordinarily and necessarily incurred by you in furtherance of the Company’s business upon submission of such substantiation as may be required under, and otherwise in accordance with, the Company’s expense reimbursement policy in effect
from time to time. 
 (b) Relocation Expenses. 
 (i) The Company and you hereby acknowledge that you presently own a personal residence in Winnetka, Illinois (the “Illinois
Home”) and that, in connection with your employment by the Company hereunder, you propose to move to Wisconsin and purchase a new residence in or in the area surrounding Dane County, Wisconsin (the “Wisconsin Home”). 
 (ii) During the period ending on your relocation to the Wisconsin Home, the Company shall pay or reimburse you, up to the aggregate amount
of One Hundred Thousand Dollars ($100,000) (the “Commuting/Moving Expense Allowance”), for the following expenses that are incurred by you in commuting from the Illinois Home in connection with your employment with the Company:
(i) reasonable rental costs for you to lease a studio apartment or comparable temporary housing in the Dane County area; and (ii) an allowance for gas and other expenses associated with the use of your vehicle at the rate of $.0445 per
mile for weekend travel between the Illinois Home and such temporary housing (collectively, the “Commuting Expenses”). Such payments or 

  

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reimbursements shall be made on the Company’s first regular payday in each calendar month within such period after the Company’s receipt of your
statement therefor as contemplated by subparagraph 3(b)(iii). 
 (iii) In addition, the Company shall pay or reimburse
you, up to an aggregate amount equal to the Commuting/Moving Expense Allowance reduced by the aggregate amount paid or reimbursed under subparagraph 3(b)(ii), regarding reimbursement of your commuting expenses, for the following expenses that are
incurred by you in connection with your relocation to the Wisconsin Home if such relocation is completed by March 31, 2007: (i) your and your spouse’s travel (including meals and lodging) from the Illinois Home to Wisconsin and return
for the principal purpose of searching for a new residence to be the Wisconsin Home, (ii) interest payments under any mortgage encumbering your Illinois Home pending its sale after your purchase of the Wisconsin Home based on the principal
amount outstanding and the regularly scheduled amortization of principal and interest thereunder as of the date first written above, (iii) the reasonable costs of the sale of the Illinois Home such as realtor fees, and (iv) moving your
household goods and personal effects from the Illinois Home to the Wisconsin Home. Such payment or reimbursement shall be made within ten (10) days after the Company’s receipt of your statement therefor as contemplated by
subparagraph 3(b)(v). 
 (iv) If your relocation to Wisconsin is completed by March 31, 2007, and if the sum of the
amounts paid or reimbursed under subparagraphs 3(b)(ii), regarding reimbursement of your commuting expenses, and 3(b)(iii), regarding reimbursement of your moving expenses, are less in the aggregate than the Commuting/Moving Expense Allowance, then
the Company will pay you the amount of such shortfall at the time it makes the payment under subparagraph 3(b)(iii), regarding reimbursement of your moving expenses. 
 (v) Notwithstanding the above, as a condition to any payment or reimbursement pursuant to this subparagraph 3(b), you shall provide
such documentation and proof of the expenses for which you may seek such payment or reimbursement as the Company may reasonably request. Furthermore, you will be responsible for any taxes on such payments or reimbursements, which will be subject to
required withholding taxes. 
 (c) Fringe Benefits. During the term of your employment, you will be entitled to
participate in any health insurance, disability insurance, retirement, and other similar fringe benefit plans of the kinds and in the amounts now or at any time during such term provided generally to other senior employees of the Company. You
acknowledge that you have no rights in any such plans except as expressly provided under the terms of such plans and that such plans may be terminated, modified or supplemented at any time. You also will be entitled to vacations during the term of
your employment in accordance with the Company’s policies as in effect from time to time for senior executives of the Company, but no less than three weeks of vacation in any twelve-month period. Copies of any plans or other documents
describing these benefits will be provided to you upon request. 
  

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 4. Restrictive Agreement. You acknowledge that you are bound by that certain Employment,
Confidential Information, Invention Assignment, and Arbitration Agreement dated January 20, 2006 (the “Restrictive Agreement”). 
 5. Noncompetition and Nonsolicitation of Customers. You agree that: 
 (a) Noncompetition. During the
term of your employment, and during the one-year period following the termination of your employment, for whatever reason, you will not, without the prior written consent of the Company, at any time perform any services substantially similar to the
services that you performed for the Company in the one year period ending on the Resignation Date for any Competitor (including, without limitation, by advising or consulting with such Competitor about any of the management, operations, business,
financial strategy or sales function matters regarding which you performed any such services for the Company) in furtherance of the Competitor’s, or in furtherance of the Competitor’s efforts to enter into the, business of developing or
manufacturing gene expression or gene sequencing DNA microarrays, or developing gene expression or gene sequencing DNA microarray services, or offering for sale, selling or providing such microarrays or services, in each case, to be offered for
sale, sold or provided, as the case may be, in the life science research market or the pharmaceutical market in any state or province, as the case may be, in which the Company then is offering for sale, selling or providing, as the case may be, or
has within the one hundred eighty (180) day period ending on the Separation Date offered, sold or provided, as the case may be, any of its gene expression or gene sequencing DNA microarrays or microarray services in the life science research
market or to any business engaged in research, development, manufacture and/or sale of pharmaceuticals (the “pharmaceutical market”). For purposes hereof, “Competitor” means an entity or any other person engaging in the business
of developing or manufacturing gene expression or gene sequencing DNA microarrays, or developing gene expression or gene sequencing DNA microarray services, or offering for sale, selling or providing such microarrays or services, in each case, in
the life science research market or the pharmaceutical market; provided, however, that if such business is conducted by such person through a division or other business subunit of such person, then “Competitor” shall mean only such
division or business subunit. 
 (b) Nonsolicitation. During the term of your employment, you will not, without the
prior written consent of the Company, directly or indirectly, divert or attempt to divert Customers’ business from the Company or its subsidiaries anywhere the Company or its subsidiaries does or is taking steps to do business. The term
“Customer” shall mean any individual or entity for whom/which the Company or its subsidiaries has provided services or products or made a proposal to perform services or provide products. During the one-year period following the
termination of your employment with the Company, for whatever reason, you will not, directly or indirectly, solicit business from any Restricted Customer in any manner which competes with products or services offered by the Company or any of its
subsidiaries or, directly or indirectly, divert or attempt to divert any Restricted Customer’s business from the Company or its subsidiaries. For purposes hereof, a “Restricted Customer” is any individual or entity who/which meets
both of the following conditions: (i) for whom or for which the Company or its subsidiaries provided products or services during the 24 months preceding the termination of your employment and (ii) with whom and with which 

  

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you had direct contact on behalf of the Company or its subsidiaries during the term of your employment and during the 24 months preceding the termination of
your employment. 
 6. Employee Acknowledgements and Disclosures. 
 (a) Injunctive Relief. You recognize that irreparable and incalculable injury will result to the Company and its businesses and
properties, including those conducted or held through any of its subsidiaries, in the event of your breach of any of the restrictions imposed by Paragraph 5 above. You therefore agree that, in the event of any such actual, impending or
threatened breach, the Company will be entitled, in addition to any other remedies and damages available to it, to temporary and permanent injunctive relief (without the necessity of posting a bond or other security) restraining the violation, or
further violation, of such restrictions by you and by any other person or entity from whom/which you may be acting or who/which is acting for you or in concert with you. 
 (b) Reasonableness of Restrictions. You acknowledge and represent that the scope of the restrictions contained in this Agreement
are appropriate, necessary and reasonable for the protection of the business, goodwill and property rights of the Company and its subsidiaries. You further acknowledge that the restrictions imposed will not prevent you from earning a living in the
event of, and after, the term of your employment for whatever reason. 
 7. Employment at Will; Termination. 
 (a) At Will Relationship. Your employment by the Company is at will and may be terminated at any time, upon thirty
(30) days’ prior written notice, by you or by the Company for any reason or no reason. Nothing contained in this Agreement or the Award Agreement will be construed as conferring upon you any right to remain employed by the Company or
affect the right of the Company to terminate your employment at any time. 
 (b) Notice of Termination. Any termination
of your employment by the Company and/or its subsidiaries, or termination by you for Good Reason will be communicated by Notice of Termination to the other party hereto. A “Notice of Termination” means a written notice which
specifies a Date of Termination (which date shall be on or after the date of the Notice of Termination) and, if applicable, indicates the provision in this Agreement applying to the termination and sets forth in reasonable detail the facts and
circumstances claimed to provide a basis for termination of your employment under the provision so indicated. 
 8. Compensation and
Benefits upon Termination. 
 (a) Payments and Benefits. Upon your termination of employment, the Company will pay
to you (i) your salary through your Date of Termination, (ii) your unpaid bonus, if any, attributable to any complete fiscal year of the Company ended before the Date of Termination, and (iii) such other benefits in which you are
vested or are otherwise entitled through the Date of Termination. In addition, if prior to the three (3) year anniversary of this Agreement first written above your employment with the Company is terminated (i) by the Company other than in
the event of Cause or (ii) by you in the event of Good Reason, then you shall become entitled to receive an amount equal to the amount of your then current annual base salary plus the amount of your target bonus for the calendar year which
includes the Date of 

  

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Termination or, if one has not been set for such year, the immediately prior calendar year. Such amount shall be paid to you in a lump sum not later than
thirty (30) days after the Date of Termination. However, if the payment of such amount at such time would subject you to a penalty under Section 409A of the Internal Revenue Code because you are a “specified employee” within the
meaning of Section 409A(a)(2)(B)(i) and no other exceptions to the penalty are available, such payment will be delayed until the earliest date permissible following the Date of Termination. Except as expressly provided above in this
Paragraph 8, the Award Agreement, or by law, the Company will have no further obligations to you following your termination of employment. 
 (b) Release of Claims. Notwithstanding the foregoing, you will have no right to receive the amount described in the second sentence of Paragraph 8(a), above, unless and until you execute, and there shall be
effective following any statutory period for revocation, a release in a form reasonably acceptable to the Company that irrevocably and unconditionally releases, waives, and fully and forever discharges the Company and its subsidiaries and its and
their past and current directors, officers, employees, and agents from and against any and all claims, liabilities, obligations, covenants, rights, demands and damages of any nature whatsoever, whether known or unknown, anticipated or unanticipated,
relating to or arising out of your employment with the Company or its subsidiaries, including without limitation claims arising under the Age Discrimination and Employment Act of 1967, as amended, Title VII of the Civil Rights Act of 1964, as
amended, or the Civil Rights Act of 1991, but excluding any claims covered any applicable worker’s compensation act. Furthermore, your right to receive such amount is conditioned upon your performance of the obligations stated in
Paragraph 5, above, regarding noncompetition and nonsolitication of customers, and the obligations stated in the Restrictive Agreement. In the event of any material breach of any such obligations after payment of such amount, you will become
obligated to return such amount to the Company. 
 9. Certain Definitions. The following terms as used herein shall have the following
respective meanings: 
 (a) “Date of Termination” means the date specified in the Notice of Termination where
required (which date shall be on or after the date of the Notice of Termination) or in any other case upon your ceasing to perform services for the Company and/or its subsidiaries. 
 (b) “Cause” means any of the following: 
 (i) your repeated failure to perform your employment duties and/or assigned work in a competent, diligent and satisfactory manner as
determined by the Board of Directors in its reasonable judgment, including, without limitation, any act of insubordination or dereliction of duty in the course of your employment with the Company and/or any of its subsidiaries by you; 
 (ii) your commission of any material act of dishonesty or disloyalty involving the Company or any of its subsidiaries, including, without
limitation, your commission of an act of fraud, embezzlement or theft or your breach of trust in connection with your duties or in the course of your employment with the Company and/or any of its subsidiaries; 
  

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 (iii) your chronic absence from work other than by reason of a serious health condition;

 (iv) your commission of a crime which, in the reasonable judgment of the Board of Directors, is substantially related to
the circumstances of your position with the Company or any of its subsidiaries or which has a material adverse effect on the business of the Company or any of its subsidiaries; or 
 (v) the willful engaging by you in conduct which is demonstrably and materially injurious to the Company or any of its subsidiaries.

 For purposes of this Agreement, no act, or failure to act, on your part will be deemed “willful” unless done, or omitted to be done, by you not
in good faith. 
 (c) “Good Reason” means, without your consent, the occurrence of any one or more of the
following during your employment with the Company: (i) any reduction by the Company of your duties or responsibilities which reduction is material based on your overall duties and responsibilities (ignoring incidental duties and
responsibilities) prior to and after such reduction which remains uncured, if cure thereof is necessary, ten (10) business days after you have given written notice to the Company which specifies such reduction and your objection thereto;
(ii) any job requirement imposed by the Company that you change your principal office to a location more than seventy five (75) miles from Dane County, Wisconsin; or (iii) any material breach of any obligation in this Agreement
of the Company for the payment or provision of compensation or other benefits to you, which remains uncured ten (10) business days after you have given written notice to the Company which specifies the breach. 
 10. Miscellaneous. 
 (a) Binding Effect. This Agreement will be binding on the Company and its successors and will inure to the benefit of and be enforceable by your personal or legal representatives, heirs and successors. 
 (b) Governing Law. This Agreement and all questions of its interpretation, performance and enforcement and the rights and remedies
of parties will be determined in accordance with the laws of the State of Wisconsin without regard to the laws of any other jurisdiction that otherwise would govern under conflict of law principles. 
 (c) Integration. This Agreement supersedes any and all prior agreements, whether written or oral, between the Company or any
representative thereof and you relating to the services performed by you for the Company or your compensation for such services other than the Restrictive Agreement, which shall not be superseded hereby, and all such prior agreements are null and
void. 
 (d) Notices. Any notice required or permitted to be given under this Agreement will be in writing and will be
deemed given: (i) upon personal delivery to the party 

  

 7 

 
to be notified, (ii) when sent by confirmed facsimile if sent during normal business hours of the recipient, if not, then on the next business day,
(iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (iv) one (1) day after deposit with a nationally recognized overnight courier, specifying next day
delivery, with written verification of receipt at the following addresses or to such other addresses either party shall specify by like notice: 
 if to the Company: 
 NimbleGen Systems Inc. 
 One Science Court 
 Madison, WI 53711 
 Attn: President or Chairman of the Board 
 with a copy to: 
 Kenneth C.
Hunt, Esq. 
 Godfrey & Kahn, S.C. 
 780 North Water Street 
 Milwaukee, Wisconsin 53202 
 and if to you: 
 David S. Snyder 
 1097 Ash Street 
 Winnetka, IL 60093 
 (e) Amendment. The Agreement may be amended or modified only upon the written consent of the Company and you. 
 (f) No Conflicting Obligations or Third Party Consents. You hereby represent and warrant to the Company that (i) neither the
execution of this Agreement by you nor the performance of any of your obligations or duties hereunder will conflict with or violate or constitute a breach of the terms of any contractual, statutory or other obligation; and (ii) you are not
required to obtain the consent of any firm, corporation or other entity or person in order to enter into this Agreement or to perform any of your obligations or duties hereunder. 
 (g) In the event that you commence litigation against the Company to collect any payment from the Company to you hereunder and you are the
prevailing party in such litigation, you shall be entitled to receive reimbursement from the Company of your costs and expenses, including reasonable attorneys’ fees, in such litigation. 
  

 8 

 If this letter correctly sets forth your understanding of our agreement, please sign a copy in the space
provided below and return it to the Company. 
  

	
	Very truly yours,
	
	NIMBLEGEN SYSTEMS INC.
	
	/s/ Thomas M. Palay
	Thomas M. Palay
	Vice Chairman of the Board of Directors and Vice President

 I confirm my agreement with 
 the terms and conditions of this letter. 
  

			
	
	/s/ David S. Snyder
	Date:	 	  

  

 9

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