Document:

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                                                                    EXHIBIT 10.5

                                BANK OF BOTETOURT

                            Summary Plan Description
                                  January 2001

     This summary plan description explains in simple terms the essential
features of the Virginia Bankers Association Master Defined Contribution Plan
for Bank of Botetourt (the "Bank"). The Table of Contents below will help you
locate information in this summary on various specific Plan provisions.

     This summary plan description is intended to give you a general overview of
the Plan. It necessarily generalizes for the sake of clarity and conciseness.
This document is only a summary of the Plan. Therefore, if there is a
discrepancy between it and the legal documents governing the Plan, the legal
documents will control. If a participant would like more information concerning
the Plan, including obtaining copies of the Plan's legal documents, he or she
should contact the Plan Administrator.

                                Table of Contents
                                -----------------

                                                                            Page

Purpose of the Plan......................................................     3

Eligibility and Participation............................................     3

Contributions to the Plan................................................     3
  Employee Contributions.................................................     3
    Elective Contributions...............................................     3
  Employer Contributions.................................................     3
    Matching Contributions...............................................     3
    Profit Sharing Contributions.........................................     3
      Determination of Amount ...........................................     3
      Covered Participants...............................................     4
      Allocation of Contributions........................................     4

Retirement Dates.........................................................     4
  Early Retirement Date..................................................     4
  Normal Retirement Date.................................................     4
  Delayed Retirement Date................................................     4

Vesting..................................................................     4
  Employee Contributions.................................................     4
  Employer Matching and Profit Sharing Contributions.....................     4
    Vesting Service......................................................     4
    Vesting Schedule.....................................................     4
    Automatic Vesting....................................................     5
    Break-in-Service.....................................................     5

Forfeitures..............................................................     5
  Forfeiture Events......................................................     5

<PAGE>

  Restoration of Amounts Forfeited.......................................     6
  Allocation of Forfeited Amounts........................................     6

                                                                            Page

Investment of Contributions..............................................     6

Account Balances and Valuation...........................................     6

Distribution of Benefits.................................................     6
  Retirement.............................................................     6
  Termination of Employment..............................................     6
  Beneficiary............................................................     6

Loans....................................................................     6

Hardship Withdrawals.....................................................     6

Beneficiary Designation..................................................     7

Tax Considerations.......................................................     7

Termination or Amendment.................................................     7

Name and Type of Plan; Fiduciaries; Other Matters........................     7
  Name of Plan...........................................................     8
  Type of Plan...........................................................     8
  Plan Number............................................................     8
  Plan Sponsor...........................................................     8
  Administration of the Plan.............................................     8
  Trustee................................................................     8
  Service of Legal Process...............................................     8
  Trust Fund and Investment Managers.....................................     8
  Plan Year..............................................................     8
  Insurance..............................................................     8
  Qualified Domestic Relations Orders ("QDROs")..........................     8

Claims Procedure.........................................................     8

Your Rights Under ERISA..................................................     9

                                        2

<PAGE>

1.   Purpose of the Plan. The Bank has established the Plan to reward its
     -------------------
     employees for their loyal and dedicated service to the Bank. The Plan
     represents an important benefit through which the Bank compensates its
     employees for their work in contributing to the Bank's success.

     The primary purpose of the Plan is to provide eligible employees greater
     financial security during their retirement years. If you are an eligible
     employee, you will have the opportunity to save by making pre-tax
     contributions from your compensation to the Plan. By making your own
     pre-tax contributions, you will be entitled to receive matching
     contributions from the Bank. In addition, as long as profits permit, the
     Bank may make its own profit sharing contributions for the benefit of
     eligible employees. When you retire, you will be able to receive the value
     of the contributions you have made as well as those the Bank has made on
     your behalf, plus any earnings on such contributions. The savings
     accumulated under this Plan, along with the savings and benefits you may
     derive from other sources, can help ensure that you are not faced with
     financial worries at retirement.

2.   Eligibility and Participation. Any salaried employee (other than a leased
     -----------------------------
     employee or a person who is not a common law employee) who is at least
     twenty-one years old and who has been employed by the Bank for at least
     twelve (12) months is eligible to participate in the Plan. If these
     eligibility requirements are met, an employee may become a participant on
     the Plan's next semi-annual entry date.

3.   Contributions to the Plan.
     -------------------------

     a.   Employee Contributions.
          ----------------------

          i.   Elective Contributions. You may elect to make pre-tax
               ----------------------
               contributions to the Plan of up to 21% of your covered
               compensation. "Covered compensation" means your gross income as
               reported on your IRS W-2 plus any amount by which that income has
               been reduced because of your participation in a cafeteria or
               similar plan. It does not include compensation you are paid prior
               to your becoming an eligible employee, nor amounts paid as
               overtime, bonuses or commissions. The amount you elect to
               contribute must be in whole percentage terms and will be by
               payroll deduction. You can change any such election semi-annually
               by giving appropriate notice to the Plan Administrator. The
               amount you contribute, as well as the amount the Bank
               contributes, and any earnings on such contributions, are not
               taxed until you withdraw them from the Plan. By avoiding taxation
               until a later date, the amount you contribute to the Plan on a
               pre-tax basis generally will be larger than what you would
               otherwise have been able to save outside a qualified plan
               (assuming the same investment return).

     b.   Employer Contributions.
          ----------------------

          i.   Matching Contributions. The Bank will make matching contributions
               ----------------------
               on your behalf when you elect to make pre-tax contributions to
               the Plan. The amount of the Bank's matching contribution will be
               50% of the amount you elect to contribute on a pre-tax basis, up
               to 6% of your covered compensation.

          ii.  Profit Sharing Contributions. Each Plan Year the Bank may make a
               ----------------------------
               profit sharing contribution to the Plan in accordance with the
               following rules:

                                        3

<PAGE>

               A.   Determination of Amount. The amount of such contribution, if
                    -----------------------
                    any, is within the discretion of the Bank and will be
                    determined during each Plan Year.

               B.   Covered Participants. Such contributions shall be allocated
                    --------------------
                    to "covered participants." You will be a covered participant
                    if you are an eligible employee on the last day of the Plan
                    Year for which such contribution is being made and you have
                    at least 1,000 hours of service for such year. However, if
                    during the Plan Year you die or retire on your normal,
                    early, or delayed retirement date while an eligible
                    employee, you will be a covered participant regardless of
                    whether you are credited with 1,000 hours of service for
                    such Plan Year.

               C.   Allocation of Contributions. The Bank's contribution is
                    ---------------------------
                    allocated to your account based on the proportion of your
                    covered compensation to the covered compensation of all
                    covered participants. In other words, if your covered
                    compensation for the Plan Year is 1/100 of the total covered
                    compensation of all covered participants, the amount
                    allocated to your account will be 1/100 of the Bank's total
                    contribution to the Plan for that Plan Year.

4.   Retirement Dates. The following retirement dates are provided under the
     ----------------
     Plan:

     a.   Early Retirement Date. The date you retire before your Normal
          ---------------------
          Retirement Date if you have reached age 55 while an employee and have
          at least 10 years of vesting service.

     b.   Normal Retirement Date. Your 65th birthday.
          ----------------------

     c.   Delayed Retirement Date. The date you retire after your Normal
          -----------------------
          Retirement Date.

5.   Vesting. Vesting means that you are entitled to all or a percentage of your
     -------
     accrued benefit in the Plan regardless of whether you continue to work for
     the Bank. In other words, the vested portion of your benefit cannot be
     taken away or "forfeited" (although it may be adjusted based on investment
     earnings or losses). However, even though you may be vested, you generally
     may not receive your benefit until a later date. The following rules apply
     in determining when you are vested:

     a.   Employee Contributions. You are always 100% vested in amounts that you
          ----------------------
          contribute to the Plan as elective contributions.

     b.   Employer Matching and Profit Sharing Contributions. You are vested in
          --------------------------------------------------
          amounts the Bank contributes on your behalf as matching and profit
          sharing contributions by reference to a vesting schedule, which
          relates to your years of service. These concepts are explained below.

          i.   Vesting Service. The vesting schedule is based on years of
               ---------------
               service. In general, you will receive credit for a year of
               vesting service if you have 1,000 or more hours of service in a
               Plan Year. You will be credited with one (1) hour of service for
               each actual hour you work and for certain other reasons such as
               vacation, holiday, or sickness. No more than 501 hours of service
               will be credited to you for any single continuous period of
               absence from work.

          ii.  Vesting Schedule. You will be vested in your accrued benefit
               ----------------
               under the Plan in accordance with the following vesting schedule:

                                        4

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                     Number of Years
                    of Vesting Service   Vested Interest
                    ------------------   ---------------

                    Less than 3 years            0%
                          3 years               20%
                          4 years               40%
                          5 years               60%
                          6 years               80%
                          7 years              100%

               If the Plan ever becomes a "Top-Heavy Plan," the following
               vesting schedule applies:

                     Number of Years
                    of Vesting Service   Vested Interest
                    ------------------   ---------------

                     Less than 3years            0%
                          3 years              100%

               In general, the Plan will be a top-heavy plan if more than 60% of
               the benefits under this Plan are allocated to key employees. Key
               employees include officers who make more than $70,000, one of the
               top ten owners who makes over $35,000 and who owns at least 1/2%
               of the Bank, a more than 1% owner of the bank who makes over
               $150,000, or a 5% owner of the Bank. The $70,000 and $35,000
               amounts may be adjusted for inflation from time to time.

          iii. Automatic Vesting. You will be fully vested regardless of your
               -----------------
               years of vesting service if:

               1.   You retire on your normal, early, or delayed retirement
                    date.

               2.   You die while employed by the Bank.

          iv.  Break-in-Service. A year of broken service is a Plan Year in
               ----------------
               which you are credited with fewer than 501 hours of service with
               the Bank. However, if an absence from work is due to maternity or
               paternity, then you will be credited with eight (8) hours of
               service for each day of absence, but only up to 501 hours of
               service in the first or second year of absence in order to
               prevent you from experiencing a year of broken service. (See
               discussion of forfeitures below.)

6.   Forfeitures.
     -----------

     a.   Forfeiture Events. An employee sometimes leaves the Bank before he or
          -----------------
          she has become fully vested in his or her benefit under the Plan. When
          this occurs, the non-vested portion of such employee's benefit is
          forfeited and divided among the remaining participants. An employee's
          non-vested portion of his or her benefit will be forfeited upon the
          earlier of the following events:

          i.   The date the employee incurs five (5) consecutive years of broken
               service.

                                        5

<PAGE>

          ii.  The date of the employee's death after termination of employment.

          iii. The end of the Plan Year in which an employee is paid his or her
               entire vested accrued benefit after termination of employment (a
               "cash-out").

          iv.  The end of the Plan Year in which an employee's employment with
               the Bank ends, if he or she has no vested accrued benefit (a
               "deemed cash-out").

     b.   Restoration of Amounts Forfeited. If a person incurs forfeiture
          --------------------------------
          because of a cash-out or a deemed cash-out, and such person becomes an
          employee before incurring five (5) consecutive years of broken service
          after the date of such forfeiture, the amount forfeited may be
          restored.

     c.   Allocation of Forfeited Amounts. Any amounts permanently forfeited
          -------------------------------
          under the Plan shall be allocated to participants on the same basis as
          contributions are allocated. That is, forfeited amounts will be
          allocated proportionately based on a participant's covered
          compensation to the covered compensation of all participants.

7.   Investment of Contributions. You will have a choice as to how contributions
     ---------------------------
     you make, and those the Bank makes on your behalf, are invested. You will
     receive information describing each investment option available under the
     Plan. Obviously, you should select the investment option which you believe
     is most appropriate for you, given your age, risk tolerance, other savings,
     etc. The Plan allows you to change your investment direction daily.

8.   Account Balances and Valuation. The assets of the Plan are held in a
     ------------------------------
     separate trust fund, within which you have your own separate account.
     Earnings and losses on the Plan's assets, including amounts held in your
     account, are determined daily. You will receive quarterly statements
     showing your account balance. These statements will also show how much you
     have contributed, how much the Bank has contributed, and the earnings or
     losses on such contributions.

9.   Distribution of Benefits. You will be eligible to receive your vested
     ------------------------
     accrued benefit under the Plan when you retire or otherwise terminate
     employment with the Bank.

     a.   Retirement. Upon your retirement, you may choose to receive payment of
          ----------
          your vested accrued benefit in a lump sum, or in periodic payments
          over ten (10) years, or a combination or these two. However, if your
          vested accrued benefit is less than $5,000, your benefit will be paid
          in a lump sum.

     b.   Termination of Employment. If your employment is terminated for
          -------------------------
          reasons other than retirement, you may receive payment of your vested
          accrued benefit in a lump sum, upon reaching retirement, in periodic
          payments over ten (10) years, or a combination of these two. However,
          if your vested accrued benefit is less than $5,000, your benefit will
          be paid in a lump sum.

     c.   Beneficiary. If you die while employed by the Bank, or after you
          -----------
          retire or otherwise terminate employment with the Bank, your vested
          accrued benefit will be paid to your beneficiary in accordance with
          the distribution rules discussed in a. and b. above.

10.  Loans. The Plan allows you to obtain a loan from the Plan for up to 50% of
     -----
     your vested accrued benefit. For details, you should obtain a copy of the
     Plan's Loan Policy from the Plan Administrator.

                                        6

<PAGE>

11.  Hardship Withdrawals. The Plan is intended to provide you with supplemental
     --------------------
     income at retirement, but you may, if you choose, withdraw funds from your
     account before you retire under certain circumstances. The Plan allows you
     to make non-hardship withdrawals from your own contributions to the Plan.
     Participants who have reached age 59 1/2 may make non-hardship withdrawals
     from the Bank's contributions to the Plan. In addition, you may make
     "hardship" withdrawals from the amount representing the Bank's contribution
     to the Plan. A "hardship" means an immediate and heavy need for financial
     assistance because of any of the following reasons:

     a.   medical expenses incurred by you or a dependent which are not
          reimbursable by insurance or otherwise;

     b.   the purchase of your principal residence or the making of major
          improvements or repairs to it;

     c.   education expenses or related costs for you or a dependent; or

     d.   other losses of a catastrophic nature that are not reimbursable by
          insurance.

     In addition, you may make withdrawals from your own pre-tax elective
     contributions to the Plan if you suffer a "severe hardship." A "severe
     hardship" means an immediate and heavy need for financial assistance
     because of any of the following reasons:

     a.   medical expenses incurred by you or a dependent which are not
          reimbursable by insurance or otherwise;

     b.   the purchase of your principal residence;

     c.   college tuition and related costs; or

     d.   the prevention of your eviction or the foreclosure of your mortgage.

     The Plan Administrator shall make all determinations as to whether a
     "hardship" or "severe hardship" exists.

12.  Beneficiary Designation. You may designate a beneficiary to receive any
     -----------------------
     benefit payable under the Plan by completing the appropriate form. Your
     spouse must consent to such designation in writing if you are married at
     the time of your death (whether or not you are married when you designate
     the beneficiary). If you do not designate a beneficiary, or your
     beneficiary dies before you, your benefit will be paid to your spouse or,
     if you have no surviving spouse, your estate.

13.  Tax Considerations. Amounts contributed on your behalf under the Plan are
     ------------------
     generally not subject to income tax until such amounts are paid to you. You
     should consult with a tax adviser to review your particular circumstances
     before you receive a withdrawal or distribution from the Plan.

14.  Termination or Amendment. The Bank plans to maintain this Plan
     ------------------------
     indefinitely, but reserves the right to terminate or amend it at any time.
     In the event of the termination of the Plan, or the complete discontinuance
     of all contributions to the Plan, each participant in the Plan would become
     fully vested in the portion of his or her account not previously vested.
     Upon termination of the Plan, all funds held in the Plan may continue to be
     held in trust until the regular payment time under the Plan, or may be
     distributed to you, as determined by the Bank in accordance with the
     provisions of the Plan.

                                        7

<PAGE>

15.  Name and Type of Plan; Fiduciaries; Other Matters. The Employee Retirement
     -------------------------------------------------
     Income Security Act of 1974 ("ERISA") requires that certain specific
     information be set forth in the summary plan description. The information
     in this section is provided in order to comply with ERISA's requirements
     and inform you of the features of the Plan.

     a.   Name of Plan. Virginia Bankers Association Master Defined Contribution
          ------------
          Plan for Bank of Botetourt.

     b.   Type of Plan. The Plan is classified as a profit sharing plan with a
          ------------
          "cash or deferred arrangement" under Section 401(k) of the Internal
          Revenue Code.

     c.   Plan Number. 002.
          -----------

     d.   Plan Sponsor. Bank of Botetourt is the Plan Sponsor. The Internal
          ------------
          Revenue Service has assigned the Bank Employer Identification Number
          (EIN) 54-01322390.

     e.   Administration of the Plan. The Plan is administered by the VBA
          --------------------------
          Benefits Corporation as Plan Administrator. Its address is 700 East
          Main Street, Suite 1411, P. O. Box 462, Richmond, Virginia 23218-0462.
          Its business phone number is (804) 643-8060. The Plan Administrator
          has discretionary authority to interpret provisions of the Plan and
          determine eligibility for benefits.

     f.   Trustee. The Trustee of the Plan is the VBA Benefits Corporation and
          -------
          its address is set forth under e. above.

     g.   Service of Legal Process. Legal process may be served on any officer
          ------------------------
          or employee of the Plan Administrator/Trustee at the address set forth
          under e. above.

     h.   Trust Fund and Investment Managers. The assets of the Plan are held in
          ----------------------------------
          a trust fund by the Plan Trustee. The Trust agreement under which
          assets of the Plan are held is part of the Virginia Bankers
          Association Master Defined Contribution Plan. The assets in the trust
          fund are invested and managed by one or more investment managers.
          Currently, the investment manager is Reliance Trust Company, 3295
          Northeast Road, N.E., Atlanta, Georgia 30340-4099.

     i.   Plan Year. For purposes of maintaining the Plan's fiscal records, the
          ---------
          Plan Year is the calendar year, i.e., the twelve (12) month period
          beginning January 1st and ending December 31st.

     j.   Insurance. Because this Plan is a Defined Contribution "Profit
          ---------
          Sharing" Plan, benefits are not insured by the Pension Benefit
          Guaranty Corporation.

     k.   Qualified Domestic Relations Orders ("QDROs"). Any participant or
          ---------------------------------------------
          beneficiary may obtain without charge from the Plan Administrator a
          copy of the Plan's procedures governing QDRO determinations.

16.  Claims Procedure. Benefits under the Plan are normally payable
     ----------------
     automatically without any need for you to file a formal claim. The
     following procedure applies if you disagree with the amount of benefits
     paid to you under the Plan or you wish to claim a benefit which has not
     been paid to you.

     Your claim for benefits under the Plan must be made in writing and
     submitted to the Plan Administrator. If your claim is denied in whole or in
     part, the Plan Administrator will notify you of the denial within 90 days
     after receipt of your claim. The claim denial notice will be written in
     such a manner that you can understand it and will contain (1) the specific
     reason for denial, (2) a specific reference to the Plan

                                        8

<PAGE>

     provision upon which the denial is based, (3) a description of any
     additional material or information that is needed which may change the
     decision to deny your claim, as well as an explanation of why the material
     or information is needed, and (4) an explanation of how you can have the
     decision reviewed. If you do not receive notification in the 90-day period,
     you should consider your claim denied.

     If additional time is needed to make a decision on your claim, you'll be
     given written notification of the reason for the delay and when you may
     expect to receive a decision. The maximum delay will never be more than 90
     days after the end of the first 90-day period. If you do not receive
     notification within 90 days or a decision on your claim within 180 days,
     you can assume your claim is denied.

     You, or your duly authorized representative, may request, in writing, that
     the Plan Administrator conduct a full and fair review of the denial. You
     must submit this request to the Plan Administrator within 60 days after you
     receive the written notice of denial, or at a later time that the Plan
     Administrator finds reasonable under the circumstances. In connection with
     this review, you or your representative may review pertinent documents and
     may submit issues and comments, in writing, as to why you think your claim
     should not be denied.

     The Plan Administrator will deliver to you a written decision on your claim
     within 60 days of its receipt of your request for review. If, however,
     there are special circumstances that require more time for processing your
     claim, this period may be extended to 120 days. If this extension is
     required, you will be notified in writing before the end of the first
     60-day period. The Plan Administrator's decision will (1) be written in
     such a manner that you can understand it, and (2) include specific
     references to the Plan provision upon which the decision is based. If you
     do not receive a decision on review by the end of the first 60-day period
     plus any required extension, you should consider your claim denied on
     review.

17.  Your Rights Under ERISA. Each participant in the Plan is entitled to the
     -----------------------
     following rights and protections under ERISA.

     You can examine, free of charge, all of the official documents related to
     the Plan, such as plan documents and all documents filed with U.S.
     Department of Labor, in your Plan Administrator's office.

     If you like, you can get your own copies of plan documents by writing to
     the Plan Administrator. You may have to pay a reasonable charge to cover
     the cost of photocopying.

     Once a year, you will automatically receive a summarized annual financial
     report for the Plan whose benefit is provided through the Plan Trustee.

     Once a year, you can get a statement telling you whether you have a right
     to receive a retirement benefit under the Plan at normal retirement age
     (age 65), and if so, what your benefit would be at normal retirement age if
     you stop working under the Plan now. If you do not have a right to a
     benefit, the statement will tell you how many more years you have to work
     to get a right to a retirement benefit. You must request this statement in
     writing. The Plan is not required to give this statement more than once a
     year, but it must be provided free of charge.

     In addition to creating rights for Plan participants, ERISA imposes duties
     upon the people who run the Plan. These people are called fiduciaries and
     have a duty to act prudently and in the interest of you and other Plan
     participants and beneficiaries.

     No one, including your employer or any other person, may fire you or
     discriminate against you in any way to prevent you from obtaining a benefit
     under any Plan or exercising your rights under ERISA.

                                        9

<PAGE>

     If your claim for a benefit is in any way denied, you must receive a
     written explanation of the reason for the denial. You have the right to
     have the Plan review and reconsider your claim.

     Under ERISA, there are steps you can take to enforce these rights. For
     instance, if you request materials from the Plan Administrator and do not
     receive them within thirty (30) days, you may file suit in a federal court.
     In such a case, the court may require the Plan Administrator to provide the
     materials and pay you up to $100 a day until you receive the materials,
     unless they were not sent because of reasons beyond the control of the Plan
     Administrator.

     If you have a claim for benefits that is denied or ignored, in whole or in
     part, you may file suit in a state or federal court. If it should happen
     that the Plan fiduciaries misuse the Plan's money, or if you are
     discriminated against for exercising your rights, you may seek assistance
     from the U.S. Department of Labor, or you may file suit in a federal court.
     The court will decide who should pay court costs and legal fees. If you are
     successful, the court may order the person you have sued to pay these costs
     and fees. If you lose, the court may order you to pay these costs and fees,
     for example, if it finds your claim is frivolous.

     If you have questions about the Plan, you should contact the Plan
     Administrator. If you have any questions about this statement or your
     rights under ERISA, you should contact the nearest Area Office of the U. S.
     Labor-Management Services Administration, Department of Labor.

                                       10<PAGE>

                                                                   EXHIBIT 10.23

================================================================================

                          SECURITIES PURCHASE AGREEMENT

                                      AMONG

                            ALLOS THERAPEUTICS, INC.

                                       AND

                    PERSEUS-SOROS BIOPHARMACEUTICAL FUND, LP

                                   ----------

                              DATED: APRIL 24, 2002

                                   ----------

================================================================================

<PAGE>

                                Table of Contents

<Table>
<Caption>
                                                                                                           Page
                                                                                                           ----
<S>                                                                                                        <C>
ARTICLE I DEFINITIONS........................................................................................1

         1.1      Definitions................................................................................1

ARTICLE II PURCHASE AND SALE OF COMMON STOCK.................................................................6

         2.1      Purchase and Sale of Common Stock..........................................................6

         2.2      Use of Proceeds............................................................................6

         2.3      Closing....................................................................................6

ARTICLE III REPRESENTATIONS AND WARRANTIES OF THE COMPANY....................................................6

         3.1      Organization...............................................................................6

         3.2      No Contravention...........................................................................6

         3.3      Governmental Authorization; Third Party Consents...........................................7

         3.4      Due Authorization; Binding Effect..........................................................7

         3.5      Litigation.................................................................................7

         3.6      Compliance with Laws.......................................................................8

         3.7      Capitalization.............................................................................8

         3.8      Contractual Obligation.....................................................................8

         3.9      SEC Documents; Financial Statements........................................................9

         3.10     Liabilities................................................................................9

         3.11     No Material Adverse Change; Ordinary Course of Business....................................9

         3.12     Taxes.....................................................................................10

         3.13     Insurance.................................................................................11

         3.14     Employee Benefit Plans....................................................................11

         3.15     NASDAQ Compliance.........................................................................12

         3.16     Intellectual Property.....................................................................12

         3.17     Environmental Matters.....................................................................14

         3.18     FDA Approval..............................................................................14

         3.19     Investment Company........................................................................14

         3.20     Private Offering..........................................................................14

         3.21     Broker's, Finder's or Similar Fees........................................................15
</Table>

                                        i
<PAGE>

<Table>
<S>                                                                                                        <C>
ARTICLE IV REPRESENTATIONS AND WARRANTIES OF THE PURCHASER..................................................15

         4.1      Existence and Power.......................................................................15

         4.2      Authorization; No Contravention...........................................................15

         4.3      Governmental Authorization; Third Party Consents..........................................15

         4.4      Binding Effect............................................................................15

         4.5      Purchase for Own Account..................................................................16

         4.6      Restricted Securities.....................................................................16

         4.7      Broker's, Finder's or Similar Fees........................................................16

         4.8      Accredited Investor.......................................................................16

         4.9      Purchaser Bears Economic Risk.............................................................16

         4.10     Purchaser Can Protect Its Interests.......................................................17

         4.11     Residence.................................................................................17

ARTICLE V CONDITIONS TO THE OBLIGATION OF THE PURCHASER TO CLOSE............................................17

         5.1      Secretary's Certificate...................................................................17

         5.2      Purchased Shares..........................................................................17

         5.3      Registration Rights Agreement.............................................................17

         5.4      Opinion of Counsel........................................................................17

ARTICLE VI CONDITIONS TO THE OBLIGATION OF THE COMPANY TO CLOSE.............................................18

         6.1      Payment of Purchase Price.................................................................18

         6.2      Registration Rights Agreement.............................................................18

ARTICLE VII CERTAIN COVENANTS...............................................................................18

         7.1      Restrictions on Transfer.  ...............................................................18

         7.2      Legend....................................................................................18

         7.3      Right to Acquire..........................................................................19

ARTICLE VIII MISCELLANEOUS..................................................................................20

         8.1      Survival of Representations and Warranties................................................20

         8.2      USRPHC....................................................................................20

         8.3      Fees......................................................................................20

         8.4      Publicity; Confidentiality................................................................21

         8.5      Notices...................................................................................21

         8.6      Successors and Assigns; Third Party Beneficiaries.........................................22
</Table>

                                       ii
<PAGE>

<Table>
<S>                                                                                                        <C>
         8.7      Amendments and Waivers....................................................................22

         8.8      Counterparts..............................................................................22

         8.9      Headings..................................................................................23

         8.10     Severability..............................................................................23

         8.11     Rules of Construction.....................................................................23

         8.12     Entire Agreement..........................................................................23

         8.13     Further Assurances........................................................................23

         8.14     GOVERNING LAW.............................................................................23
</Table>

                                    Exhibits

Exhibit A         Bylaws
Exhibit B         Amended and Restated Certificate of Incorporation
Exhibit C         Registration Rights Agreement
Exhibit D         Form of Opinion of Cooley Godward LLP

                                       iii
<PAGE>

                          SECURITIES PURCHASE AGREEMENT

                  This SECURITIES PURCHASE AGREEMENT (this "Agreement") is made
and entered into as of April 24, 2002, by and among Allos Therapeutics, Inc., a
Delaware corporation (the "Company"), and Perseus-Soros BioPharmaceutical Fund,
LP, a Delaware limited liability partnership (the "Purchaser").

                  WHEREAS, upon the terms and conditions set forth in this
Agreement, the Company proposes to issue and sell to the Purchaser, and the
Purchaser proposes to acquire from the Company, 2,500,000 shares (the "Purchased
Shares") of the common stock of the Company, $0.01 par value per share (the
"Common Stock"), upon the terms and conditions set forth herein.

                  NOW, THEREFORE, in consideration of the mutual covenants and
agreements set forth herein, the parties hereto agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

                  1.1 Definitions. As used in this Agreement, and unless the
context requires a different meaning, the following terms have the meanings
indicated:

                  "Affiliate" shall mean any Person who is an "affiliate" as
defined in Rule 12b-2 of the General Rules and Regulations under the Exchange
Act.

                  "Agreement" means this Agreement as the same may be amended,
supplemented or modified in accordance with the terms hereof.

                  "Board of Directors" means the Board of Directors of the
Company.

                  "Business Day" means any day other than a Saturday, Sunday or
other day on which commercial banks in the State of Colorado are authorized or
required by law or executive order to close.

                  "Bylaws" means the Bylaws of the Company in effect on the
Closing Date and attached hereto as Exhibit A, as the same may be amended from
time to time.

                  "Certificate of Incorporation" means the Amended and Restated
Certificate of Incorporation of the Company in effect on the Closing Date and
attached hereto as Exhibit B, as the same may be amended from time to time.

                  "Claims" has the meaning set forth in Section 3.5 of this
Agreement.

                  "Closing" has the meaning set forth in Section 2.3 of this
Agreement.

<PAGE>
                                                                               2

                  "Closing Date" has the meaning set forth in Section 2.3 of
this Agreement.

                  "Closing Price" means, with respect to the shares of Common
Stock, the last reported sales price of the Common Stock as reported on the
Nasdaq Stock Market.

                  "Code" means the Internal Revenue Code of 1986, as amended, or
any successor statute thereto.

                  "Commission" means the United States Securities and Exchange
Commission or any similar agency then having jurisdiction to enforce the
Securities Act.

                  "Common Stock" has the meaning set forth in the recitals to
this Agreement.

                  "Commonly Controlled Entity" means any entity which is under
common control with the Company within the meaning of Code section 414(b), (c),
(m) or (o).

                  "Company" has the meaning set forth in the preamble to this
Agreement.

                  "Company Plan" means each Plan that the Company maintains or
contributes to, or is a party to or otherwise has any liability in respect of.

                  "Contractual Obligation" means, as to any Person, any
provision of any security issued by such Person or of any agreement,
undertaking, contract, indenture, mortgage, deed of trust or other instrument to
which such Person is a party or by which it or any of its property is bound.

                  "Company Option" has the meaning set forth in Section 7.3 of
this Agreement.

                  "Company Option Period" has the meaning set forth in Section
7.3 of this Agreement.

                  "Copyrights" means any foreign or United States copyright
registrations and applications for registration thereof, and any non-registered
copyrights.

                  "Delivery Date" has the meaning set forth in Section 8.2 of
this Agreement.

                  "Environmental Laws" means federal, state, local and foreign
laws, regulations, and codes, as well as orders, decrees, judgments or
injunctions, issued, promulgated, approved or entered thereunder relating to
pollution, protection of the environment or public health and safety.

                  "ERISA" means the Employee Retirement Income Security Act of
1974, as amended.

<PAGE>
                                                                               3

                  "Exchange Act" means the Securities Exchange Act of 1934, as
amended, and the rules and regulations of the Commission thereunder.

                  "FDA" has the meaning set forth in Section 3.18 of this
Agreement.

                  "Financial Statements" has the meaning set forth in Section
3.9 of this Agreement.

                  "GAAP" means United States generally accepted accounting
principles in effect from time to time.

                  "Governmental Authority" means the government of any nation,
state, city, locality or other political subdivision thereof, any entity
exercising executive, legislative, judicial, regulatory or administrative
functions of or pertaining to government, and any corporation or other entity
owned or controlled, through stock or capital ownership or otherwise, by any of
the foregoing.

                  "Intellectual Property" has the meaning set forth in Section
3.15 of this Agreement.

                  "Internet Assets" means any Internet domain names and other
computer user identifiers and any rights in and to sites on the worldwide web,
including rights in and to any text, graphics, audio and video files and html or
other code incorporated in such sites.

                  "Letter" has the meaning set forth in Section 8.2 of this
Agreement.

                  "Liabilities" has the meaning set forth in Section 3.10 of
this Agreement.

                  "Lien" means any mortgage, deed of trust, pledge,
hypothecation, assignment, encumbrance, lien (statutory or other) or preference,
priority, right or other security interest or preferential arrangement of any
kind or nature whatsoever (excluding preferred stock and equity related
preferences).

                  "Material Adverse Effect" has the meaning set forth in Section
3.1 of this Agreement.

                  "Nasdaq Stock Market" has the meaning set forth in Section
3.15 of this Agreement.

                  "Offer Price" has the meaning set forth in Section 7.3 of this
Agreement.

                  "Offered Securities" has the meaning set forth in Section 7.3
of this Agreement.

                  "Offering Notice" has the meaning set forth in Section 7.3 of
this Agreement.

<PAGE>
                                                                               4

                  "Patents" means any foreign or United States patents and
patent applications, including any divisions, continuations,
continuations-in-part, substitutions or reissues thereof, whether or not patents
are issued on such applications and whether or not such applications are
modified, withdrawn or resubmitted.

                  "Permitted Transferee" has the meaning set forth in Section
7.3 of this Agreement.

                  "Permits" has the meaning set forth in Section 3.6 of this
Agreement.

                  "Person" means any individual, firm, corporation, partnership,
trust, incorporated or unincorporated association, joint venture, joint stock
company, limited liability company, Governmental Authority or other entity of
any kind, and shall include any successor (by merger or otherwise) of such
entity.

                  "Plan" means any employee benefit plan, arrangement, policy,
program, agreement or commitment (whether or not an employee plan within the
meaning of section 3(3) of ERISA), including, without limitation, any
employment, consulting or deferred compensation agreement, executive
compensation, bonus, incentive, pension, profit-sharing, savings, retirement,
stock option, stock purchase or severance pay plan, any life, health, disability
or accident insurance plan, whether oral or written, whether or not subject to
ERISA, as to which the Company or any Commonly Controlled Entity has or in the
future could have any direct or indirect, actual or contingent liability.

                  "Product" has the meaning set forth in Section 3.18 of this
Agreement.

                  "Purchased Shares" has the meaning set forth in the recitals
to this Agreement.

                  "Purchaser" has the meaning set forth in the preamble to this
Agreement.

                  "Registration Rights Agreement" means the Registration Rights
Agreement substantially in the form attached hereto as Exhibit C.

                  "Requirements of Law" means, as to any Person, any law,
statute, treaty, rule, regulation, qualification, license or franchise or
determination of an arbitrator or a court or other Governmental Authority or
stock exchange, in each case applicable or binding upon such Person or any of
its property or to which such Person or any of its property is subject or
pertaining to any or all of the transactions contemplated or referred to herein.

                  "SEC Documents" has the meaning set forth in Section 3.9 of
this Agreement.

                  "Securities Act" means the Securities Act of 1933, as amended,
and the rules and regulations of the Commission thereunder.

<PAGE>
                                                                               5

                  "Software" means any computer software programs, source code,
object code, data and documentation, including, without limitation, any computer
software programs that incorporate and run the Company's pricing models,
formulae and algorithms.

                  "Subsidiary" has the meaning set forth in Section 3.12(a) of
this Agreement.

                  "Tax Returns" has the meaning set forth in Section 3.12(a) of
this Agreement.

                  "Taxes" means any federal, state, provincial, county, local,
foreign and other taxes (including, without limitation, income, profits,
windfall profits, alternative, minimum, accumulated earnings, personal holding
company, capital stock, premium, estimated, excise, sales, use, occupancy, gross
receipts, franchise, ad valorem, severance, capital levy, production, transfer,
withholding, employment, unemployment compensation, payroll and property taxes,
import duties and other governmental charges and assessments), whether or not
measured in whole or in part by net income, and including deficiencies,
interest, additions to tax or interest, and penalties with respect thereto, and
including expenses associated with contesting any proposed adjustments related
to any of the foregoing.

                  "Trade Secrets" means any trade secrets, research records,
processes, procedures, manufacturing formulae, technical know-how, technology,
blue prints, designs, plans, inventions (whether patentable and whether reduced
to practice), invention disclosures and improvements thereto.

                  "Trademarks" means any foreign or United States trademarks,
service marks, trade dress, trade names, brand names, designs and logos,
corporate names, product or service identifiers, whether registered or
unregistered, and all registrations and applications for registration thereof.

                  "Trading Day" means, so long as the Common Stock is listed or
admitted to trading on a national securities exchange, a day on which the
principal national securities exchange on which the Common Stock is listed is
open for the transaction of business, or, if the Common Stock is not so listed
or admitted for trading on any national securities exchange, a day on which
Nasdaq Stock Market is open for the transaction of business.

                  "Transaction Documents" means, collectively, this Agreement
and the Registration Rights Agreement.

                  "Treasury Regulations" has the meaning set forth in Section
8.2 of this Agreement.

                  "USRPHC" has the meaning set forth in Section 3.12(b) of this
Agreement.

<PAGE>
                                                                               6

                                   ARTICLE II

                        PURCHASE AND SALE OF COMMON STOCK

                  2.1 Purchase and Sale of Common Stock. Subject to the terms
and conditions herein set forth, the Company agrees to issue and sell to the
Purchaser, and the Purchaser agrees to purchase from the Company, on the Closing
Date, the Purchased Shares at a purchase price of $6.00 per share for an
aggregate purchase price of $15,000,000.

                  2.2 Use of Proceeds. The Company shall use the proceeds from
the sale of the Purchased Shares to the Purchaser to fund the Company's working
capital.

                  2.3 Closing. Subject to the satisfaction or waiver in writing
of the conditions set forth in Articles V and VI, the closing of the sale and
purchase of the Purchased Shares (the "Closing") shall take place at the offices
of Paul, Weiss, Rifkind, Wharton & Garrison, 1285 Avenue of the Americas, New
York, New York 10019, at 10:00 a.m., local time on the date hereof, or at such
other time, place and date that the Company and the Purchaser may agree upon in
writing (the "Closing Date"). On the Closing Date, the Company shall deliver to
the Purchaser a certificate in definitive form and registered in the name of the
Purchaser, representing the Purchased Shares, against delivery by the Purchaser
to the Company of the aggregate purchase price therefor by wire transfer of
immediately available funds.

                                   ARTICLE III

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

                  Except as otherwise described or disclosed in (i) the SEC
Documents or (ii) a Schedule of Exceptions delivered by the Company to the
Purchaser at the Closing, the Company represents and warrants to the Purchaser
as of the date of this Agreement as follows:

                  3.1 Organization. The Company is a corporation duly
incorporated and validly existing in good standing under the laws of the
jurisdiction of its organization. The Company has all requisite corporate power
and authority to own, operate and occupy its properties and to conduct its
business as presently conducted and is registered or qualified to do business
and in good standing in each jurisdiction in which it owns or leases property or
transacts business and where the failure to be so qualified would have a
material adverse effect upon the business, financial condition, properties or
operations of the Company ("Material Adverse Effect"), and no proceeding has
been instituted in any such jurisdiction revoking, limiting or curtailing, or
seeking to revoke, limit or curtail, such power and authority or qualification.

                  3.2 No Contravention. The execution and delivery of this
Agreement and the Registration Rights Agreement and the performance by the
Company of the transactions contemplated hereby and thereby, including the
issuance and sale of the

<PAGE>
                                                                               7

Purchased Shares to be sold by the Company hereunder, will not (A) conflict with
or constitute a violation of, or default (with the passage of time or otherwise)
under, (i) any bond, debenture, note or other evidence of indebtedness, or any
material lease, contract, indenture, mortgage, deed of trust, loan agreement,
joint venture or other agreement or instrument to which the Company is a party
or by which it or its property is bound, where such conflict, violation or
default would reasonably be expected to result in a Material Adverse Effect,
(ii) the Certificate of Incorporation, Bylaws or other organizational documents
of the Company, or (iii) any law, administrative regulation, ordinance or order
of any court or governmental agency, arbitration panel or authority binding upon
the Company or its property, where such conflict, violation or default would
reasonably be expected to result in a Material Adverse Effect, or (B) result in
the creation or imposition of any Lien or restriction whatsoever upon any of the
material properties or assets of the Company or an acceleration of indebtedness
pursuant to any obligation, agreement or condition contained in any material
bond, debenture, note or any other evidence of indebtedness or any material
indenture, mortgage, deed of trust or any other agreement or instrument to which
the Company is a party or by which it is bound or to which any of the property
or assets of the Company is subject.

                  3.3 Governmental Authorization; Third Party Consents. No
approval, consent, authorization or other action by, or notice to, or filing
with, any Governmental Authority or any other Person, and no lapse of a waiting
period under any Requirements of Law, is necessary or required in connection
with the execution, delivery or performance (including, without limitation, the
sale, issuance and delivery of the Purchased Shares) by, or enforcement against,
the Company of this Agreement and the Registration Rights Agreement (subject to
any filings or consents required to be obtained by the Company from any
Governmental Authority as contemplated therein) or the transactions contemplated
hereby and thereby, except such as has been duly and validly obtained, given or
filed, or with respect to any filings that must be made after the Closing, as
will be filed in a timely manner.

                  3.4 Due Authorization; Binding Effect. The Company has all
requisite corporate power and authority to execute, deliver and perform its
obligations under the Transaction Documents. The Transaction Documents have been
duly executed and delivered by the Company, and constitute the legal, valid and
binding obligations of the Company, enforceable against the Company in
accordance with their terms, except as enforceability may be limited by
applicable bankruptcy, insolvency, reorganization, fraudulent conveyance or
transfer, moratorium or similar laws affecting the enforcement of creditors'
rights generally and by general principles of equity relating to enforceability
(regardless of whether considered in a proceeding at law or in equity), and
except as enforceability of the indemnification and contribution provisions of
the Registration Rights Agreement may be limited by applicable laws or public
policy relating thereto.

                  3.5 Litigation. Except as disclosed in the SEC Documents,
there are no actions, suits, proceedings, claims, complaints, disputes,
arbitrations or investigations (collectively, "Claims") pending or, to Company's
knowledge, threatened in writing, at law, in equity, in arbitration or before
any Governmental Authority against the Company nor is the Company aware that
there is any basis for any of the foregoing.

<PAGE>
                                                                               8

                  3.6 Compliance with Laws. The Company is in compliance with
all Requirements of Law and all orders issued by any court or Governmental
Authority against the Company, except where any noncompliance would not
reasonably be expected to have a Material Adverse Effect. To the Company's
knowledge, there is no existing or proposed Requirement of Law which could
reasonably be expected to prohibit or restrict the Company from, or otherwise
materially adversely affect the Company in, conducting its business in any
jurisdiction in which it now conducts or proposes to conduct such business. The
Company has all material licenses, permits and approvals of any Governmental
Authority (collectively, "Permits") that are necessary for the conduct of the
business of the Company as currently conducted; (ii) such Permits are in full
force and effect; and (iii) no violations are or have been recorded in respect
of any Permit. The Company has made, or shall make as soon as practical after
the Closing, to the extent required by applicable law or regulation or
otherwise, (a) a filing of a Form D pursuant to Commission Regulation D, (b) any
required filings pursuant to state "blue sky" laws, and (c) any required filings
or notifications regarding the listing of additional shares on the Nasdaq Stock
Market.

                  3.7 Capitalization. The capitalization of the Company is
described in the SEC Documents. The Company has not issued any capital stock
since March 31, 2000 other than pursuant to employee benefit plans disclosed in
the SEC Documents. The Purchased Shares to be sold hereunder have been duly
authorized, and when issued and paid for in accordance with the terms set forth
herein, will be duly and validly issued, fully paid and nonassessable. The
outstanding shares of capital stock of the Company have been duly and validly
issued and are fully paid and nonassessable, have been issued in compliance with
all federal and state securities laws, and were not issued in violation of any
preemptive rights or similar rights to subscribe for or purchase securities.
Except as set forth in or contemplated by the SEC Documents, there are no
outstanding rights (including, without limitation, preemptive rights), material
warrants or options to acquire, or instruments convertible into or exchangeable
for, any unissued shares of capital stock or other equity interest in the
Company, or any contract, commitment, agreement, understanding or arrangement of
any kind to which the Company is a party and relating to the issuance or sale of
any capital stock of the Company, any such convertible or exchangeable
securities or any such rights, warrants or options. Without limiting the
foregoing, no preemptive right, co-sale right, registration right, right of
first refusal or other similar right exists with respect to the issuance and
sale of the Purchased Shares. Except as disclosed in the SEC Documents, there
are no stockholders agreements, voting agreements or other similar agreements
with respect to the Common Stock to which the Company is a party. The Company
does not directly or indirectly own or have any investment in any of the capital
stock of, or any other proprietary interest in, any Person, other than 222,222
shares of Series B Preferred Stock of N-Gene Research Laboratories, Inc., a
Delaware corporation. Upon consummation of the transactions contemplated hereby,
the Purchased Shares shall represent approximately 9.75% of the Company's
outstanding capital stock. The Company has not adopted a stockholders rights
plan, poison pill or similar arrangement.

                  3.8 Contractual Obligation. The contracts described in the SEC
Documents or incorporated by reference therein that are material to the Company
are in

<PAGE>
                                                                               9

full force and effect on the date hereof, and neither the Company nor, to the
Company's knowledge, any other party to such contracts is in breach of or
default under any of such contracts which breach of default would reasonably be
expected to have a Material Adverse Effect on the Company.

                  3.9 SEC Documents; Financial Statements. Since March 27, 2000,
the Company has filed all reports, schedules, forms, statements and other
documents required to be filed by it with the Commission pursuant to the
reporting requirements of the Exchange Act (all of the foregoing filed prior to
the date hereof and all exhibits included therein and financial statements and
schedules thereto and documents incorporated by reference therein being
hereinafter referred to as the "SEC Documents"). As of their respective dates,
the SEC Documents complied in all material respects with the requirements of the
Exchange Act and the rules and regulations of the Commission promulgated
thereunder applicable to the SEC Documents, and none of the SEC Documents, at
the time they were filed with the Commission, contained any untrue statement of
a material fact or omitted to state a material fact required to be stated
therein or necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading. As of their respective
dates, the financial statements of the Company (the "Financial Statements")
included in the SEC Documents complied as to form in all material respects with
applicable accounting requirements and the published rules and regulations of
the Commission with respect thereto. The Financial Statements have been prepared
in accordance with GAAP, consistently applied, during the periods involved
(except in the case of unaudited interim statements, to the extent they may
exclude footnotes or may be condensed or summary statements) and fairly present
in all material respects the financial position of the Company as of the dates
thereof and the results of its operations and cash flows for the periods then
ended (subject, in the case of unaudited statements, to normal year-end audit
adjustments). To the Company's knowledge and as of their respective dates, no
written correspondence between the Company and the Unites States Food and Drug
Administration respecting the Company's clinical trials provided by or on behalf
of the Company to the Purchaser contained any untrue statement of a material
fact or omitted to state any material fact necessary in order to make the
statements therein, in the light of the circumstance under which they were made,
not misleading.

                  3.10 Liabilities. The Company does not have any direct or
indirect obligation or liability (the "Liabilities") which if known would be
required to be reflected in the Company's financial statements in accordance
with GAAP, other than (a) Liabilities fully and adequately reflected in or
reserved against on the Financial Statements and (b) Liabilities incurred since
December 31, 2001 in the ordinary course of business. The Company has no
knowledge of any circumstance, condition, event or arrangement that could
reasonably be expected to give rise hereafter to any Liabilities of the Company
except in the ordinary course of business.

                  3.11 No Material Adverse Change; Ordinary Course of Business.
Since December 31, 2001, (a) there has not been any material adverse change in
the business, financial condition, properties or operations of the Company, nor
is a change reasonably expected that could have a Material Adverse Effect, (b)
the Company has not participated

<PAGE>
                                                                              10

in any transaction that would reasonably be expected to have a Material Adverse
Effect or otherwise acted outside the ordinary course of business, including,
without limitation, declaring or paying any dividend or declaring or making any
distribution to its stockholders except out of the earnings of the Company, (c)
the Company has not increased the compensation of any of its officers or the
rate of pay of any of its employees, except as part of regular compensation
increases in the ordinary course of business, (d) the Company has not created or
assumed any Lien on a material asset of the Company, (e) the Company has not
entered into any Contractual Obligation, other than in the ordinary course of
business and (f) there has not occurred a material change in the accounting
principles or practice of the Company except as required by reason of a change
in GAAP.

                  3.12 Taxes.

                           (a) The Company has filed or caused to be filed, or
has properly filed extensions for, all tax returns, reports, forms and other
such documents ("Tax Returns") that are required to be filed and has paid or
caused to be paid all Taxes as shown on said returns and on all material
assessments received by it to the extent that such Taxes have become due, except
Taxes the validity or amount of which is being contested in good faith by
appropriate proceedings and with respect to which adequate reserves, in
accordance with GAAP, have been set aside. Such Tax Returns are true and correct
in all material respects. The Company's financial statements fully accrue all
Tax liabilities with respect to all periods through the dates thereof in
accordance with GAAP. No additional Tax assessment against the Company or any
business entity in which the Company has at any time controlled or owned an
interest in (a "Subsidiary") has been heretofore proposed or threatened in
writing by any Governmental Authority for which provision has not been made on
its balance sheet.

                           (b) With respect to all Tax Returns of the Company
and any of its Subsidiaries, (i) no audit is in progress and no extension of
time is in force with respect to any date on which any Tax Return was or is to
be filed and no waiver or agreement is in force for the extension of time for
the assessment or payment of any Tax; and (ii) to the Company's knowledge, there
is no unassessed deficiency proposed or to the knowledge of Company threatened
against the Company or any of its Subsidiaries. Neither the Company nor any of
its Subsidiaries knows of any change in the rates or basis of assessment of any
Tax (other than federal income tax), of the Company and its Subsidiaries which
would reasonably be expected to have a Material Adverse Effect. Neither the
Company nor any of its Subsidiaries has agreed to or is required to make any
adjustments under section 481 of the Code by reason of a change of accounting
method or otherwise. None of the respective assets of the Company or any of its
Subsidiaries is required to be treated as being owned by any Person, other than
the Company or any of its Subsidiaries, pursuant to the "safe harbor" leasing
provisions of Section 168(f)(8) of the Code. The Company is not a "United States
real property holding corporation" (a "USRPHC") as that term is defined in
Section 897(c)(2) of the Code and the regulations promulgated thereunder.

<PAGE>
                                                                              11

                  3.13 Insurance. The Company maintains and will continue to
maintain insurance of the types and in the amounts that the Company reasonably
believes is adequate for its business, including, but not limited to, insurance
covering all real and personal property owned or leased by the Company against
theft, damage, destruction, acts of vandalism and all other risks customarily
insured against by similarly situated companies, all of which insurance is in
full force and effect.

                  3.14 Employee Benefit Plans.

                           (a) Neither the Company nor any Commonly Controlled
Entity maintains or contributes to, or has within the preceding six years
maintained or contributed to, or may have any liability with respect to any Plan
subject to Title IV of ERISA or Section 412 of the Code or any "multiple
employer plan" within the meaning of the Code or ERISA. Each Company Plan that
is intended to be qualified under Section 401(a) of the Code (and related trust,
insurance contract or fund) has been established and administered in accordance
with its terms, and complies in all material respects in form and in operation
with the applicable requirements of ERISA, the Code and other applicable
Requirements of Law. All contributions (including all employer contributions and
employee salary reduction contributions) which are plan assets for purposes of
ERISA have been paid to each Company Plan.

                           (b) No Claim with respect to the administration or
the investment of the assets of any Company Plan (other than routine claims for
benefits) is pending.

                           (c) Each Company Plan that is intended to be
qualified under Section 401(a) of the Code is so qualified and has been so
qualified during the period since its adoption and each trust created under any
such Plan is exempt from tax under Section 501(a) of the Code and has been so
exempt since its creation.

                           (d) To the Company's knowledge, no event has occurred
in connection with which the Company or any Company Plan, directly or
indirectly, could be subject to any material liability under ERISA, the Code or
any other law, regulation or governmental order applicable to any Company Plan,
or under any agreement, instrument, statute, rule of law or regulation pursuant
to or under which the Company has agreed to indemnify any person against
liability incurred under, or for a violation or failure to satisfy the
requirement of, any such statute, regulation or order.

                           (e) The Company does not have any obligations to
provide or any direct or indirect liability, whether contingent or otherwise,
with respect to the provision of health or death benefits to or in respect of
any former employee, except as may be required pursuant to Section 4980B of the
Code and the corresponding provisions of ERISA and the cost of which are fully
paid by such former employees.

                           (f) There are no unfunded obligations under any
Company Plan which are not fully reflected on the Financial Statements in
accordance with GAAP.

<PAGE>
                                                                              12

                           (g) The Company has no liability, whether absolute or
contingent, including any obligations under any Company Plan, with respect to
any misclassification of any person as an independent contractor rather than as
an employee.

                  3.15 NASDAQ Compliance. The Common Stock is registered
pursuant to Section 12(g) of the Exchange Act, and is listed on The Nasdaq
National Market (the "Nasdaq Stock Market"), and the Company has taken no action
designed to, or reasonably likely to have the effect of, terminating the
registration of the Common Stock under the Exchange Act or delisting the Common
Stock from the Nasdaq Stock Market. The Company has complied with all
requirements of the National Association of Securities Dealers, Inc. with
respect to the issuance of the Purchased Shares and the listing thereof on the
Nasdaq Stock Market. The Company has not taken and will not, in violation of
applicable law, take, any action outside the ordinary course of business
designed to or that might reasonably be expected to cause or result in unlawful
manipulation of the price of the Common Stock to facilitate the sale or resale
of the Purchased Shares.

                  3.16 Intellectual Property.

                           (a) (i) The Company is the owner of all, or, to the
Company's knowledge, has the license or right to use, sell and license all of,
the Copyrights, Patents, Trade Secrets, Trademarks, Internet Assets, Software
and other proprietary rights (collectively, "Intellectual Property") that are
used in connection with its business as presently conducted or contemplated in
the SEC Documents, free and clear of all Liens.

                                    (ii) None of the Intellectual Property is
subject to any outstanding order, and no action, suit, proceeding, hearing,
investigation, charge, complaint, claim or demand is pending or, to the
Company's knowledge, threatened in writing, which challenges the validity,
enforceability, use, sale, licensing or ownership of any Intellectual Property.

                                    (iii) With regard to all Intellectual
Property licenses, sublicenses, and other agreements under which the Company is
either a licensor or licensee, except such licenses, sublicenses and other
agreements relating to off-the-shelf software which is commercially available on
a retail basis and used solely on the computers of the Company, the Company has
substantially performed all obligations imposed upon it thereunder, and is not,
nor to the Company's knowledge is any other party thereto, in breach of or
default thereunder in any material respect, nor to the Company's knowledge is
there any event which with notice or lapse of time or both would reasonably be
expected to constitute a material default thereunder. All of the Intellectual
Property licenses are valid, enforceable and in full force and effect, and will
continue to be so on identical terms immediately following the Closing, except
as enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, fraudulent conveyance or transfer, moratorium or similar laws
affecting the enforcement of creditors' rights generally and by general
principles of equity relating to enforceability (regardless of whether
considered in a proceeding at law or in equity).

<PAGE>
                                                                              13

                                    (iv) To the Company's knowledge, none of the
Intellectual Property currently sold or licensed by the Company to any Person or
used by or licensed to the Company by any Person infringes upon or otherwise
violates any Intellectual Property rights of others.

                           (b) To the Company's knowledge, no Person is
infringing upon or otherwise violating the Intellectual Property rights of the
Company. Except as disclosed in the SEC Documents, the Company is not a party to
or bound by any license or other agreement requiring the payment by the Company
of any royalty payment (excluding such agreements relating to software licensed
for use solely on the computers of the Company), other than that certain
Development and License Agreement by and between the Company and N-Gene Research
Laboratories, Inc., a Delaware corporation, dated March 11, 2002.

                           (c) No former employer of any employee of the
Company, and no current or former client of any consultant of the Company, has
made a claim against the Company, or any of its Affiliates or, to the Company's
knowledge, against any other Person, that such employee or such consultant is
utilizing Intellectual Property of such former employer or client.

                           (d) To the Company's knowledge, no employee of the
Company is in violation of any term of any employment agreement, patent or
invention disclosure agreement or other contract or agreement relating to the
relationship of such employee with the Company or any prior employee. Except as
described in the SEC Documents, it is not necessary for the business of the
Company to use any Intellectual Property owned by any director, officer,
employee or consultant of the Company (or Persons the Company presently intend
to hire). To the Company's knowledge, at no time during the conception or
reduction to practice of any of the Company's Intellectual Property was any
developer, inventor or other contributor to such Intellectual Property operating
under any grants from any Governmental Authority or subject to any employment
agreement, invention assignment, nondisclosure agreement or other Contractual
Obligation with any Person that could reasonably be expected to adversely affect
the Company's rights to its Intellectual Property.

                           (e) To the Company's knowledge upon reasonable
inquiry in accordance with sound business practice and business judgment, (i)
all of the Company's Intellectual Property rights (other than the Company's
Patents) are valid and enforceable, and (ii) all of the Company's Patents are
valid, and neither the validity nor the enforceability of any such Patents have
been challenged by any third party. The Company has taken all reasonably steps
required in accordance with sound business practice and business judgment to
maintain and protect each item of Intellectual Property owned by the Company. To
the Company's knowledge, none of the Trade Secrets of the Company, wherever
located, the value of which is contingent upon maintenance of confidentiality
thereof, have been disclosed to any Person other than employees, representatives
and agents of the Company, except as required pursuant to the filing of a patent
application by the Company, and except to third parties pursuant to signed

<PAGE>
                                                                              14

confidentiality agreements requiring such third parties to maintain the
confidentiality of such Trade Secrets.

                           (f) All present employees of the Company have
executed and delivered proprietary invention agreements with the Company, and
are obligated under the terms thereof to assign all inventions made by them
during the course of employment to the Company.

                  3.17 Environmental Matters. To its knowledge, the Company is
in compliance with all applicable Environmental Laws. There is no civil,
criminal or administrative judgment, action, suit, demand, claim, hearing,
notice of violation, investigation, proceeding, notice or demand letter pending
or, to the Company's knowledge, threatened against the Company pursuant to
Environmental Laws. To the Company's knowledge, there are no past or present
events, conditions, circumstances, activities, practices, incidents, agreements,
actions or plans which could reasonably be expected to prevent compliance with,
or which have given rise to or will give rise to liability which would have a
Material Adverse Effect, under Environmental Laws.

                  3.18 FDA Approval. After due investigation, (i) the Company
has no knowledge that any Governmental Authority, including, but not limited to,
the United States Food and Drug Administration (the "FDA"), will ultimately
prohibit the marketing, sale, license or use in the United States or elsewhere
of any product (including, but not limited to, RSR13) proposed to be developed,
produced or marketed by the Company or with third parties (each, a "Product"),
(ii) to the Company's knowledge, the FDA has not prohibited any product or
process from being marketed or used in the United States which product or
process is substantially similar to any Product in function or composition,
(iii) the Company has no Product on clinical hold nor any reason to expect that
any Product is reasonably likely to be placed on clinical hold, (iv) the Company
has made available to the Purchaser all submissions to the FDA and the FDA
responses (and other material correspondence received from or submitted to the
FDA), including, but not limited to, all FDA warning letters, regulatory letters
and notice of adverse finding letters and the relevant responses, received by
the Company or any agent thereof relative to the development of its Products,
including, but not limited to, RSR13, (v) none of the Company or its Affiliates
or, to the Company's knowledge, its employees or agents, has ever been
sanctioned, formally or otherwise, by the FDA, and (vi) there has not been any
suspensions or debarments by the FDA or other federal departments and state
regulatory bodies against the Company or, to the knowledge of the Company, any
current or former employee of the Company.

                  3.19 Investment Company. The Company is not an "investment
company" or an "affiliated person" of, or "promoter" or "principal underwriter"
for an investment company, within the meaning of the Investment Company Act of
1940, as amended.

                  3.20 Private Offering. No form of general solicitation or
general advertising was used by the Company or its representatives in connection
with the offer, sale or issuance of the Purchased Shares. No registration of the
Purchased Shares,

<PAGE>
                                                                              15

pursuant to the provisions of the Securities Act or any state securities or
"blue sky" laws, will be required by the offer, sale or issuance of the
Purchased Shares. The Company agrees that neither it, nor anyone acting on its
behalf, shall offer to sell the Purchased Shares or any other securities of the
Company so as to require the registration of the Purchased Shares pursuant to
the provisions of the Securities Act or any state securities or "blue sky" laws,
unless such Purchased Shares or other securities are so registered.

                  3.21 Broker's, Finder's or Similar Fees. There are no
brokerage commissions, finder's fees or similar fees or commissions payable by
the Company in connection with the transactions contemplated hereby based on any
agreement, arrangement or understanding with the Company or any action taken by
any such Person.

                                   ARTICLE IV

                 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

                  The Purchaser hereby represents and warrants to the Company as
follows:

                  4.1 Existence and Power. The Purchaser is a limited
partnership duly organized and validly existing in good standing under the laws
of the jurisdiction of its formation and has the requisite partnership power and
authority to execute, deliver and perform its obligations under the Transaction
Documents.

                  4.2 Authorization; No Contravention. The execution, delivery
and performance by the Purchaser of this Agreement and the Registration Rights
Agreement and the transactions contemplated hereby and thereby, (a) have been
duly authorized by all necessary partnership action, (b) do not contravene the
terms of the Purchaser's organizational documents, or any amendment thereof, (c)
do not violate, conflict with or result in any breach or contravention of, or
the creation of any Lien under, any Contractual Obligation of the Purchaser or
any Requirements of Law applicable to the Purchaser, and (d) do not violate any
orders of any Governmental Authority against, or binding upon, the Purchaser.

                  4.3 Governmental Authorization; Third Party Consents. No
approval, consent, authorization or other action by, or notice to, or filing
with, any Governmental Authority or any other Person, and no lapse of a waiting
period under any Requirements of Law, is necessary or required in connection
with the execution, delivery or performance (including, without limitation, the
purchase of the Purchased Shares) by, or enforcement against, the Purchaser of
this Agreement and the Registration Rights Agreement (subject to any filings or
consents required to be obtained by the Company from any Governmental Authority
as contemplated therein) or the transactions contemplated hereby and thereby.

                  4.4 Binding Effect. This Agreement and the Registration Rights
Agreement and the transactions contemplated hereby and thereby have been duly
executed and delivered by the Purchaser and constitute the legal, valid and
binding obligations of the Purchaser, enforceable against it in accordance with
its terms, except as

<PAGE>
                                                                              16

enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, fraudulent conveyance or transfer, moratorium or similar laws
affecting the enforcement of creditors' rights generally or by equitable
principles relating to enforceability (regardless of whether considered in a
proceeding at law or in equity), and except as enforceability of the
indemnification and contribution provisions of the Registration Rights Agreement
may be limited by applicable laws or public policy relating thereto.

                  4.5 Purchase for Own Account. The Purchased Shares to be
acquired by the Purchaser pursuant to this Agreement are being or will be
acquired for its own account and with no intention of distributing or reselling
such Purchased Shares or any part thereof in any transaction that would be in
violation of the securities laws of the United States, any state of the United
States or any foreign jurisdiction, without prejudice, however, to the rights of
the Purchaser at all times to sell or otherwise dispose of all or any part of
such Purchased Shares under an effective registration statement under the
Securities Act, or under an exemption from such registration available under the
Securities Act, and subject, nevertheless, to the disposition of the Purchaser's
property being at all times within its control. If the Purchaser should in the
future decide to dispose of any of such Purchased Shares, the Purchaser
understands and agrees that it may do so only in compliance with the Securities
Act and applicable state and foreign securities laws, as then in effect.

                  4.6 Restricted Securities. The Purchaser understands that the
Purchased Shares will not be registered at the time of their issuance under the
Securities Act for the reason that the sale provided for in this Agreement is
exempt pursuant to Section 4(2) of the Securities Act and that the reliance of
the Company on such exemption is predicated in part on the Purchaser's
representations set forth herein.

                  4.7 Broker's, Finder's or Similar Fees. There are no brokerage
commissions, finder's fees or similar fees or commissions payable by the
Purchaser in connection with the transactions contemplated hereby based on any
agreement, arrangement or understanding with the Purchaser or any action taken
by the Purchaser.

                  4.8 Accredited Investor. The Purchaser is an "Accredited
Investor" within the meaning of Rule 501 of Regulation D under the Securities
Act, as presently in effect.

                  4.9 Purchaser Bears Economic Risk. The Purchaser has
substantial experience in evaluating and investing in private placement
transactions of securities in companies similar to the Company so that it is
capable of evaluating the merits and risks of its investment in the Company. The
Purchaser understands that it shall bear the economic risk of the investment in
the Purchased Shares indefinitely unless the Purchased Shares are registered
pursuant to the Securities Act, or an exemption from registration is available.
The Purchaser understands that except as specifically required by the
Registration Rights Agreement, the Company has no intention of registering the
Purchased Shares. The Purchaser also understands that there is no assurance that
any registration under the Registration Rights Agreement or exemption from
registration under the Securities Act will be available and that, even if
available, such registration or

<PAGE>
                                                                              17

exemption may not allow the Purchaser to transfer all or any portion of the
Purchased Shares under the circumstances, in the amounts or at the times the
Purchaser might propose (provided that the foregoing shall in no way limit the
rights of, or any remedies available to, the Purchaser under the Registration
Rights Agreement).

                  4.10 Purchaser Can Protect Its Interests. The Purchaser
represents that by reason of its, or of its management's, business or financial
experience, the Purchaser has the capacity to protect its own interests in
connection with the transactions contemplated in this Agreement and the
Registration Rights Agreement. Further, the Purchaser is not aware of any
publication or any advertisement in connection with the transactions
contemplated by this Agreement.

                  4.11 Residence. The office or offices of the Purchaser in
which its investment decisions was made is located in New York, New York.

                                    ARTICLE V

                          CONDITIONS TO THE OBLIGATION
                            OF THE PURCHASER TO CLOSE

                  The obligation of the Purchaser to purchase the Purchased
Shares, to pay the purchase price therefor at the Closing and to perform any
obligations hereunder shall be subject to the satisfaction as determined by, or
waiver in writing by, the Purchaser of the following conditions on or before the
Closing Date:

                  5.1 Secretary's Certificate. The Purchaser shall have received
a certificate from the Company, in form and substance reasonably satisfactory to
the Purchaser dated the Closing Date and signed by the Secretary or an Assistant
Secretary of the Company, certifying (a) that the Company is in good standing
with the Secretary of State of the State of Delaware, (b) that the attached
copies of the Certificate of Incorporation, the Bylaws and resolutions of the
Board of Directors of the Company approving this Agreement and the Registration
Rights Agreement and the transactions contemplated hereby and thereby, are all
true, complete and correct and remain unamended and in full force and effect and
(c) as to the incumbency and specimen signature of each officer of the Company
executing the Transaction Documents and any other document delivered in
connection herewith on behalf of the Company.

                  5.2 Purchased Shares. The Company shall be prepared to deliver
to the Purchaser a certificate in definitive form representing the number of
Purchased Shares, registered in the name of the Purchaser.

                  5.3 Registration Rights Agreement. The Company shall have duly
executed and delivered the Registration Rights Agreement.

                  5.4 Opinion of Counsel. The Purchaser shall have received an
opinion of Cooley Godward LLP, dated the Closing Date, relating to the
transactions

<PAGE>
                                                                              18

contemplated by or referred to herein, substantially in the form attached hereto
as Exhibit D.

                                   ARTICLE VI

                          CONDITIONS TO THE OBLIGATION
                             OF THE COMPANY TO CLOSE

                  The obligation of the Company to issue and sell the Purchased
Shares and the obligation of the Company to perform its other obligations
hereunder shall be subject to the satisfaction as determined by, or waiver by,
the Company of the following conditions on or before the Closing Date:

                  6.1 Payment of Purchase Price. The Purchaser shall have
delivered to the Company the aggregate purchase price for the Purchased Shares.

                  6.2 Registration Rights Agreement. The Purchaser shall have
duly executed and delivered the Registration Rights Agreement.

                                   ARTICLE VII

                                CERTAIN COVENANTS

                  7.1 Restrictions on Transfer. The Purchaser agrees not to make
any disposition of all or any portion of the Purchased Shares unless and until:

                           (a) There is then in effect a registration statement
under the Securities Act covering such proposed disposition and such disposition
is made in accordance with such registration statement; or

                           (b) (i) the Purchaser shall have notified the Company
of the proposed disposition and shall have furnished the Company with a
statement of the circumstances surrounding the proposed disposition, and (ii) if
reasonably requested by the Company, the Purchaser shall have furnished the
Company with an opinion of counsel that such disposition will not require
registration of such shares under the Securities Act; provided that the Company
will not require opinions of counsel for transactions made pursuant to Rule 144
or for a distribution of shares by the Purchaser to its partners or former
partners in accordance with partnership interests or to any Affiliate of the
Purchaser.

                  7.2 Legend. The Purchaser acknowledges and agrees that each
certificate representing the Purchased Shares shall be stamped or otherwise
imprinted with a legend substantially similar to the following (in addition to
any legend required under applicable state securities laws) so long as required
by law:

                  THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
                  REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
                  "ACT"), OR THE SECURITIES LAWS OF ANY

<PAGE>
                                                                              19

                  STATE OF THE UNITED STATES OR ANY FOREIGN JURISDICTION. THE
                  SECURITIES REPRESENTED HEREBY MAY NOT BE OFFERED, SOLD OR
                  OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED
                  UNLESS AND UNTIL REGISTERED UNDER THE ACT OR SUCH REGISTRATION
                  IS NOT REQUIRED.

                  7.3 Right to Acquire.

                           (a) Other than with respect to any transfer(s) to an
Affiliate or distribution(s) to one or more of the limited partners of the
Purchaser (or any subsequent distribution to any shareholder, member, partner or
other interest holder of any such Person) (each, a "Permitted Transferee"), if
the Purchaser wishes to transfer in one or series of related transactions to any
third party purchaser (the "Subject Purchaser") more than 1,250,000 shares
(subject to adjustment in the event of stock splits, reverse stock splits, stock
dividends, recapitalizations, or similar events after the date hereof), the
Purchaser shall first offer such shares to the Company by sending written notice
(an "Offering Notice") to the Company. The Offering Notice shall state: (i) the
number of shares proposed to be transferred (the "Offered Securities"); (ii) the
cash purchase price per share for the Offered Securities (the "Offer Price");
(iii) the proposed transfer date; and (iv) the identity of the proposed Subject
Purchaser. For purpose of the foregoing, no investment partnership controlled by
Scott Sacane shall be deemed an Affiliate of the Purchaser for purposes of this
Section 7.3

                           (b) For a period of two Business Days after the
giving of the Offering Notice (the "Company Option Period"), the Company shall
have the right (the "Company Option") but not the obligation to purchase all
(but not less than all) of the Offered Securities at a purchase price equal to
the Offer Price and upon the terms and conditions set forth in the Offering
Notice. The right of the Company to purchase all of the Offered Securities under
this Section 7.3(b) shall be exercisable by delivering written notice of the
exercise thereof, prior to the expiration of the Company Option Period, to the
Purchaser. The failure of the Company to respond within the Company Option
Period shall be deemed to be a waiver of the Company Option. Exercise by the
Company of the Company Option shall be irrevocable unless and until waived in
writing by the Purchaser.

                           (c) If the Company exercises its option to purchase
all of the Offered Securities, the closing of the purchase of Offered Securities
by the Company pursuant to the foregoing shall be held at the executive office
of the Purchaser at 11:00 a.m., local time, on the third Business Day after
exercise by the Company of the Company Option. The Company shall deliver at the
closing payment in full, by wire transfer of immediately available funds, for
the Offered Securities purchased by it at such time. At such closing, all of the
parties to the transaction shall execute such additional documents as are
otherwise necessary or appropriate. If such closing does not take place on the
third Business Day after exercise by the Company of the Company Option, the
Purchaser may sell the Offered Securities to any Subject Purchaser and shall be
entitled to seek all other remedies available to it as a result of such failure.

<PAGE>
                                                                              20

                           (d) Unless the Company elects to purchase all, but
not less than all, of the Offered Securities, the Purchaser may sell the Offered
Securities to the Subject Purchaser on the terms and conditions not materially
more favorable to the Subject Purchaser than those set forth in the Offering
Notice; provided, however, that such sale is made pursuant to a contract entered
into within 90 days after the expiration of the Company Option Period (at which
time the Offered Securities will once again be subject to this Section 7.3 with
respect to any transfer to such Subject Purchaser).

                           (e) A condition to any transfer to a Permitted
Transferee who would own more than 1,250,000 shares (subject to adjustment in
the event of stock splits, reverse stock splits, stock dividends,
recapitalizations, or similar events after the date hereof) after giving effect
to such transfer shall be such Permitted Transferee agreeing to be bound by the
terms and conditions of this Section 7.3 with respect to any subsequent transfer
(other than to a Permitted Transferee, who shall similarly agree to be bound by
the terms and conditions of this Section 7.3, of such Permitted Transferee).

                                  ARTICLE VIII

                                  MISCELLANEOUS

               8.1 Survival of Representations and Warranties. All of the
representations and warranties made herein shall survive the execution and
delivery of this Agreement for a period of one (1) year following the end of the
Company's current fiscal year; provided that the representations and warranties
set forth in Section 3.12 shall survive through the applicable statute of
limitations.

               8.2 USRPHC. The Company covenants that it will not become a
USRPHC at any time while Purchaser owns the Purchased Shares. In the event that
Purchaser desires to sell or dispose of any of the Purchased Shares, and upon
demand by Purchaser, the Company agrees to deliver to Purchaser a letter (the
"Letter") which complies with Sections 1.1445-2(c)(3) and 1.897-2(h) of the
treasury regulations promulgated under the Code (the "Treasury Regulations"),
addressed to Purchaser, stating that the Company is not, and has not been, a
USRPHC during the period equal to the lesser of (i) the period beginning five
years prior to the date of the Letter through the date of the Letter and (ii)
the period from the date of this Agreement through the date of the Letter. The
Letter shall be delivered to Purchaser one Business Day prior to the close of
any sale of the Purchased Shares by Purchaser (the "Delivery Date"). The Letter
shall be dated as of the Delivery Date and signed by a corporate officer who
must verify under penalties of perjury that the statement is correct to his
knowledge and belief pursuant to Section 1.897-2(h) of the Treasury Regulations.

               8.3 Fees. Upon the Closing, the Company shall reimburse the
Purchaser for all of its reasonable fees, disbursements and other charges of
counsel reasonably incurred in connection with the transactions contemplated by
this Agreement.

<PAGE>
                                                                              21

               8.4 Publicity; Confidentiality. Except as may be required by
applicable Requirements of Law, none of the parties hereto shall issue a
publicity release or public announcement or otherwise make any disclosure
concerning this Agreement, the transactions contemplated hereby without prior
approval by the other party hereto; provided that the Purchaser may disclose on
its worldwide web page the name of the Company, the name of the Chief Executive
Officer of the Company, a brief description of the business of the Company, the
Company's logo and the aggregate amount of the Purchaser's investment in the
Company. If any announcement is required by applicable law or the rules of any
securities exchange or market on which such shares of Common Stock are traded to
be made by any party hereto, prior to making such announcement such party will
deliver a draft of such announcement to the other parties and shall give the
other parties reasonable opportunity to comment thereon.

               8.5 Notices. All notices, demands and other communications
provided for or permitted hereunder shall be made in writing and shall be made
by registered or certified first-class mail, return receipt requested,
telecopier, courier service or personal delivery:

                           (a) if to the Company:

                                    Allos Therapeutics, Inc.
                                    11080 CirclePoint Road, Suite 200
                                    Westminster, Colorado 80020
                                    Telecopy: (303) 426.4731
                                    Attention: Michael E. Hart

                                    with a copy to:

                                    Cooley Godward LLP
                                    380 Interlocked Crescent, Suite 900
                                    Broomfield, CO 80021
                                    Telecopy: (720) 566-4099
                                    Attention: Steven E. Segal

                           (b) if to the Purchaser:

                                    Perseus-Soros Biopharmaceutical Fund, L.P.
                                    c/o Perseus, L.L.C.
                                    2099 Pennsylvania Ave., N.W., Suite 900
                                    Washington, DC 20006-1813
                                    Telecopy: (202) 752-1315
                                    Attention: Christopher D. Earl

<PAGE>
                                                                              22

                                    with a copy to:

                                    Paul, Weiss, Rifkind, Wharton & Garrison
                                    1285 Avenue of the Americas
                                    New York, NY 10019-6064
                                    Telecopy: (212) 757-3990
                                    Attention: Bruce A. Gutenplan

All such notices, demands and other communications shall be deemed to have been
duly given when delivered by hand, if personally delivered; when delivered by
courier, if delivered by commercial courier service; five (5) Business Days
after being deposited in the mail, postage prepaid, if mailed; and when receipt
is mechanically acknowledged, if telecopied. Any party may by notice given in
accordance with this Section 8.5 designate another address or Person for receipt
of notices hereunder.

                  8.6 Successors and Assigns; Third Party Beneficiaries. This
Agreement shall inure to the benefit of and be binding upon the successors and
permitted assigns of the parties hereto as hereinafter provided. Subject to
applicable securities laws and the terms and conditions thereof, the Purchaser
may assign any of its rights under this Agreement or the Registration Rights
Agreement to any of its Affiliates. The Company may not assign any of its rights
under this Agreement without the written consent of the Purchaser. No Person
other than the parties hereto and their successors and permitted assigns is
intended to be a beneficiary of this Agreement.

                  8.7 Amendments and Waivers. No failure or delay on the part of
the Company or the Purchaser in exercising any right, power or remedy hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of
any such right, power or remedy preclude any other or further exercise thereof
or the exercise of any other right, power or remedy. The remedies provided for
herein are cumulative and are not exclusive of any remedies that may be
available to the Company or the Purchaser at law, in equity or otherwise. Any
amendment, supplement or modification of or to any provision of this Agreement,
any waiver of any provision of this Agreement, and any consent to any departure
by the Company or the Purchaser from the terms of any provision of this
Agreement, shall be effective (i) only if it is made or given in writing and
signed by the Company and the Purchaser and (ii) only in the specific instance
and for the specific purpose for which made or given. Except where notice is
specifically required by this Agreement, no notice to or demand on the Company
in any case shall entitle the Company to any other or further notice or demand
in similar or other circumstances.

                  8.8 Counterparts. This Agreement may be executed in any number
of counterparts and by the parties hereto in separate counterparts, each of
which when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement. The parties hereto confirm
that any facsimile copy of another party's executed counterpart of this
Agreement (or its signature page thereof) will be deemed to be an executed
original thereof.

<PAGE>
                                                                              23

                  8.9 Headings. The headings in this Agreement are for
convenience of reference only and shall not limit or otherwise affect the
meaning hereof.

                  8.10 Severability. If any one or more of the provisions
contained herein, or the application thereof in any circumstance, is held
invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every other respect and of
the remaining provisions hereof shall not be in any way impaired, unless the
provisions held invalid, illegal or unenforceable shall substantially impair the
benefits of the remaining provisions hereof.

                  8.11 Rules of Construction. Unless the context otherwise
requires, references to sections or subsections refer to sections or subsections
of this Agreement.

                  8.12 Entire Agreement. This Agreement, together with the
exhibits and schedules hereto, and the Registration Rights Agreement are
intended by the parties as a final expression of their agreement and intended to
be a complete and exclusive statement of the agreement and understanding of the
parties hereto in respect of the subject matter contained herein and therein.
There are no restrictions, promises, representations, warranties or
undertakings, other than those set forth or referred to herein or therein. This
Agreement, together with the exhibits and schedules hereto, and the Registration
Rights Agreement supersede all prior agreements and understandings between the
parties with respect to such subject matter.

                  8.13 Further Assurances. Each party hereto shall execute such
documents and perform such further acts as may be reasonably required or
desirable to carry out or to perform the provisions of this Agreement.

                  8.14 GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF DELAWARE, WITHOUT REGARD
TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

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<PAGE>

                  IN WITNESS WHEREOF, the undersigned have executed, or have
caused to be executed, this Securities Purchase Agreement on the date first
written above.

                                       ALLOS THERAPEUTICS, INC.

                                       By: /s/ Michael E. Hart
                                          --------------------------------------
                                          Name: Michael E. Hart
                                          Title: President and CEO

                                       PERSEUS-SOROS
                                       BIOPHARMACEUTICAL FUND, LP

                                       By:  Perseus-Soros Partners, LLC,
                                            General Partner

                                       By:  SFM Participation, L.P., Member

                                       By:  SFM AH, Inc., General Partner

                                       By: /s/ Richard D. Holahan
                                          --------------------------------------
                                          Name: Richard D. Holahan, Jr.
                                          Title: Secretary

Exhibit A         Bylaws (Incorporated by reference to our Registration
                  Statement on Form S-1 (File No. 333-95439) and amendments
                  thereto, declared effective March 27, 2000.)

Exhibit B         Amended and Restated Certificate of Incorporation
                  (Incorporated by reference to our Registration Statement on
                  Form S-1 (File No. 333-95439) and amendments thereto, declared
                  effective March 27, 2000.)

Exhibit C         Registration Rights (Incorporated by reference to
                  Exhibit 10.24 of this Form 8-K)

Exhibit D         Form of Opinion of Cooley Godward LLP (Intentionally omitted)

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