Document:

EX-10.1

 Exhibit 10.1 

FIRST AMENDMENT TO LEASE 

This FIRST AMENDMENT TO LEASE (“First Amendment”) is made and entered into as of August 12, 2021, by and between
BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”), and ORIC PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 

R E C I T A L S : 

A. Landlord and Tenant are parties to the Lease dated June 5, 2015 (the “Lease”), pursuant to which Tenant leases
approximately 33,322 rentable square feet of space (“RSF”) (the “Existing Premises”) on the second (2nd) floor of the building (the
“Building”) located at 240 East Grand Avenue, South San Francisco, California. 
 B. Landlord and Tenant desire (i) to
extend the Lease Term of the Lease, (ii) to expand the Existing Premises to include that certain space consisting of 341 rentable square feet of space commonly known as stock room #149 located on the first (1st) floor of the Building (the “Expansion Premises”), as delineated on Exhibit A attached hereto and made a part hereof, and (iii) to make other modifications to the
Lease, and in connection therewith, Landlord and Tenant desire to amend the Lease as hereinafter provided. 
 A G R
E E M E N T : 
 NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 

1. Terms. All capitalized terms when used herein shall have the same respective meanings as are given such terms in the Lease
unless expressly provided otherwise in this First Amendment. 
 2. Modification of Premises. Effective as of the date
(the “Expansion Commencement Date”) upon which Landlord delivers possession of the Expansion Premises to Tenant via the provision of a key or access card thereto (and no action by Tenant shall be required therefor), Tenant shall
lease from Landlord and Landlord shall lease to Tenant the Expansion Premises. Landlord shall deliver the Expansion Premises in in good, vacant, broom clean condition. Consequently, effective upon the Expansion Commencement Date, the Existing
Premises shall be increased to include the Expansion Premises. Landlord and Tenant hereby acknowledge that such addition of the Expansion Premises to the Existing Premises shall, effective as of the Expansion Commencement Date, increase the size of
the Premises to approximately 33,663 rentable square feet. The Existing Premises and the Expansion Premises may hereinafter collectively be referred to as the “Premises”. Landlord shall deliver the Expansion Premises promptly upon
the expiration of the current tenant’s lease thereof, which Landlord represents is November 15, 2021 and Landlord shall use commercially reasonable efforts to cause such delivery to be on or before December 1, 2021. 

 3. Condition of the Premises; Tenant Improvements. Landlord and Tenant
acknowledge that Tenant has been occupying the Existing Premises pursuant to the Lease, and therefore Tenant continues to accept the Existing Premises in its presently existing, “as is” condition. Except as otherwise set forth in the
Tenant Work Letter attached hereto as Exhibit B or in the Lease (such as ongoing maintenance obligations), Landlord shall not be obligated to provide or pay for any improvement work or services related to the improvement of the
Existing Premises. Tenant also acknowledges that, except as may be expressly set forth herein or in the Lease, neither Landlord nor any agent of Landlord has made any representation or warranty regarding the condition of the Premises, the Building,
or the Project or with respect to the suitability of the same for the conduct of Tenant’s business. In addition, except as specifically set forth in the Tenant Work Letter attached hereto as Exhibit B or in the Lease (such as
ongoing maintenance obligations), Landlord shall not be obligated to provide or pay for any improvement work or services related to the improvement of the Expansion Premises, and Tenant shall accept the Expansion Premises in its presently existing, “as-is” condition. 
 4. Lease Term. 

4.1 Extended Lease Term and Expansion Term. Landlord and Tenant acknowledge that Tenant’s lease of the Existing Premises is
scheduled to expire on May 15, 2022, pursuant to the terms of the Lease. Notwithstanding anything to the contrary in the Lease, the term of Tenant’s lease of the Existing Premises is hereby extended and shall expire coterminously with the
term of Tenant’s lease of the Expansion Premises on May 15, 2028 (the “New Lease Expiration Date”), unless sooner terminated as provided in the Lease, as hereby amended. With respect to the Existing Premises, the period
commencing on May 16, 2022 and ending on the New Lease Expiration Date shall be referred to herein as the “Extended Term.” With respect to the Expansion Premises, the period of time commencing on the Expansion Commencement Date
and terminating on the New Lease Expiration Date, shall be referred to herein as the “Expansion Term.” At any time during the Expansion Term, Landlord may deliver to Tenant a notice substantially in the form as set forth in
Exhibit C attached to the Lease, as a confirmation only of the information set forth therein, which Tenant shall execute and return to Landlord in accordance with the terms of the Lease. 

4.2 Option Term. Effective as of the date of this First Amendment, Section 2.2 of the Lease is hereby
deleted in its entirety and of no further force or effect and Tenant shall have the right to extend the Lease Term in accordance with the terms of this Section 4.2 only. 

4.2.1 Option Right. Landlord hereby grants the Tenant originally named in this First Amendment (the “Original
Tenant”), and any assignee of Original Tenant’s entire interest in the Lease that has been approved in accordance with the terms of Article 14 of the Lease (a “Permitted Assignee”), one (1) option to extend
the Lease Term for the entire Premises for a period of one (1) year (the “Option Term”). Such option to extend shall be exercisable only by written notice delivered by Tenant to Landlord not more than fifteen (15) months
nor less than twelve (12) months prior to the New Lease Expiration Date, stating that Tenant is thereby irrevocably exercising its option to lease the entire Premises during the Option Term. Upon the proper exercise of the option to extend, and
provided that, at Landlord’s option, as of the date of delivery of such notice, Tenant is not in default under the Lease after the expiration of applicable notice and cure periods and has not previously been in default under the Lease after the
expiration 

  
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of applicable notice and cure periods more than once in the twelve (12) month period prior to the date of Tenant’s attempted exercise, and as of the end of the applicable Lease Term,
Tenant is not in default under the Lease, the Lease Term shall be extended for a period of one (1) year. The rights contained in this Section 4.2.1 shall be personal to Original Tenant and any Permitted Assignee (and
not any other assignee, sublessee or Transferee, of Tenant’s interest in the Lease). In the event that Tenant fails to timely and appropriately exercise its option to extend the Lease Term, in accordance with the terms of this
Section 4.2.1, then such option shall automatically terminate and shall be of no further force or effect. 

4.2.2 Option Rent. The Base Rent payable by Tenant during the Option Term (the “Option Rent”) for all of the
Premises shall be as set forth below: 
  

													
	 Period During
Option Term
	  	Annual
Base Rent	 	  	Monthly
Installment
of Base Rent	 	  	Monthly
Rental
Rate
per
Square
Foot	 
	 May 16, 2028 –
May 15, 2029
	  	$	2,904,905.63	 	  	$	242,075.47	 	  	$	7.19	 

 5. Base Rent. 

5.1 Existing Premises. Notwithstanding anything to the contrary in the Lease as hereby amended, prior to May 16, 2022,
Tenant shall continue to pay Base Rent for the Existing Premises in accordance with the terms of the Lease. Commencing on May 16, 2022, and continuing throughout the Expansion Term, Tenant shall pay monthly installments of Base Rent for the
Existing Premises as follows, and otherwise in accordance with the terms of the Lease, provided, however, notwithstanding anything to the contrary herein, Base Rent for the period from June 1, 2022 – June 30, 2022 shall be abated:

  

													
	 Period During
Extended Term
	  	Annual
Base Rent	 	  	Monthly
Installment
of Base Rent	 	  	Monthly
Rental
Rate
per
Square
Foot	 
	 May 16, 2022 –
May 15, 2023
	  	$	2,339,204.40	 	  	$	194,933.70	 	  	$	5.85	 
	 May 16, 2023 –
May 15, 2024
	  	$	2,421,076.55	 	  	$	201,756.38	 	  	$	6.05	 
	 May 16, 2024 –
May 15, 2025
	  	$	2,505,814.23	 	  	$	208,817.85	 	  	$	6.27	 
	 May 16, 2025 –
May 15, 2026
	  	$	2,593,517.73	 	  	$	216,126.48	 	  	$	6.49	 
	 May 16, 2026 –
May 15, 2027
	  	$	2,684,290.85	 	  	$	223,690.90	 	  	$	6.71	 
	 May 16, 2027 – 
May 15, 2028
	  	$	2,778,241.03	 	  	$	231,520.09	 	  	$	6.95	 

  
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 5.2 Expansion Premises. Commencing on the Expansion Commencement Date and
continuing throughout the Expansion Term, Tenant shall pay to Landlord monthly installments of Base Rent for the Expansion Premises as follows; provided, however, notwithstanding anything to the contrary herein, Base Rent for the first full calendar
month following the Expansion Commencement Date shall be abated: 
  

													
	 Period During
Expansion Term
	  	

Annual
Base Rent	 	  	Monthly
Installment
of Base
Rent	 	  	Approximate
Monthly
Rental Rate
per
Rentable
Square Foot	 
	 Expansion Commencement Date – May 15, 2022
	  	 	N/A	 	  	$	1,565.91	 	  	$	4.5921	 
	 May 16, 2022 – May 15, 2023
	  	$	23,938.20	 	  	$	1,994.85	 	  	$	5.85	 
	 May 16, 2023 –
May 15, 2024
	  	$	24,776.04	 	  	$	2,064.67	 	  	$	6.05	 
	 May 16, 2024 –
May 15, 2025
	  	$	25,643.20	 	  	$	2,136.93	 	  	$	6.27	 
	 May 16, 2025 –
May 15, 2026
	  	$	26,540.71	 	  	$	2,211.73	 	  	$	6.49	 
	 May 16, 2026 –
May 15, 2027
	  	$	27,469.64	 	  	$	2,289.14	 	  	$	6.71	 
	 May 16, 2027 –
May 15, 2028
	  	$	28,431.07	 	  	$	2,369.26	 	  	$	6.95	 

 6. Direct Expenses. 

6.1 Existing Premises. Prior to and during the Extended Term, Tenant shall continue to be obligated to pay Tenant’s Share
of the Direct Expenses for the Existing Premises in accordance with the terms of the Lease. 
 6.2 Expansion Premises.
Commencing on the Expansion Commencement Date and continuing throughout the Expansion Term, Tenant shall pay Tenant’s Share of Direct Expenses in connection with the Expansion Premises in accordance with the terms of the Lease, provided that
with respect to the calculation of Tenant’s Share of Direct Expenses in connection with the Expansion Premises, Tenant’s Share shall equal 0.56%: 

  
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 7. Brokers. Landlord and Tenant hereby warrant to each other that they have
had no dealings with any real estate broker or agent in connection with the negotiation of this First Amendment other than CBRE, Inc. and Savills (the “Brokers”), and that they know of no other real estate broker or agent who is
entitled to a commission in connection with this First Amendment. Each party agrees to indemnify and defend the other party against and hold the other party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments, costs
and expenses (including without limitation reasonable attorneys’ fees) with respect to any leasing commission or equivalent compensation alleged to be owing on account of any dealings with any real estate broker or agent, other than the
Brokers, occurring by, through, or under the indemnifying party. The terms of this Section 7 shall survive the expiration or earlier termination of the term of the Lease, as hereby amended. 

8. Parking. In addition to Tenant’s parking rights set forth in the Lease, effective as of the Expansion Commencement Date
and continuing throughout the Expansion Term, the parking ratio set forth in the Lease shall also apply to the Expansion Premises. 
 9.
Security Deposit; Letter of Credit. 
 9.1 Return of Security Deposit. Landlord and Tenant acknowledge that, in
accordance with the Lease, Tenant has previously delivered the sum of $306,035.92 (the “Existing Security Deposit”) to Landlord as security for the faithful performance by Tenant of the terms, covenants and conditions of the Lease.
Within ten (10) days following the later to occur of (i) the full execution and delivery of this First Amendment by Landlord and Tenant, and (ii) Landlord’s receipt of the “L-C”
(as defined in Section 9.2 below) as required by the terms of Section 9 below, Landlord shall return to Tenant the full amount of the Existing Security Deposit. 

9.2 Replacement of Security Deposit with Letter of Credit; Delivery of Letter of Credit. Tenant shall deliver to Landlord,
concurrently with Tenant’s execution of this First Amendment, an unconditional, clean, irrevocable letter of credit (the “L-C”) in the amount of $467,778.70 (the “L-C Amount”), which L-C shall be issued by a money-center, solvent and nationally recognized bank (a bank which accepts deposits, maintains accounts, has a local San
Francisco Bay Area office which will negotiate a letter of credit or permits draws by facsimile, and whose deposits are insured by the FDIC) reasonably acceptable to Landlord (such approved, issuing bank being referred to herein as the
“Bank”), which Bank must have a rating from Standard and Poors Corporation of A- or better (or any equivalent rating thereto from any successor or substitute rating service selected by Lessor)
and a letter of credit issuer rating from Moody’s Investor Service of A3 or better (or any equivalent rating thereto from any successor rating agency thereto)) (collectively, the “Bank’s Credit Rating Threshold”), and
which L-C shall be in the form of Exhibit C, attached hereto. Tenant shall pay all expenses, points and/or fees incurred by Tenant in obtaining the L-C. The L-C shall (i) be “callable” at sight, irrevocable and unconditional, (ii) be maintained in effect, whether through renewal or extension, for the
period commencing on the date of this First Amendment and continuing until the date (the “L-C Expiration Date”) that is no less than sixty (60) days after the
expiration of the Lease Term as the same may be extended, and Tenant shall deliver a new L-C or certificate of renewal or extension to Landlord at least thirty

  
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(30) days prior to the expiration of the L-C then held by Landlord, without any action whatsoever on the part of Landlord, (iii) be fully assignable
by Landlord, its successors and assigns, (iv) permit partial draws and multiple presentations and drawings, and (v) be otherwise subject to the Uniform Customs and Practices for Documentary Credits
(1993-Rev), International Chamber of Commerce Publication #500, or the International Standby Practices-ISP 98, International Chamber of Commerce Publication #590.
Landlord, or its then managing agent, shall have the right to draw down an amount up to the face amount of the L-C if any of the following shall have occurred or be applicable: (A) such amount is due to
Landlord under the terms and conditions of the Lease, and has not been paid within applicable notice and cure periods (or, if Landlord is prevented by law from providing notice, within the period for payment set forth in the Lease), or
(B) Tenant has filed a voluntary petition under the U. S. Bankruptcy Code or any state bankruptcy code (collectively, “Bankruptcy Code”), or (C) an involuntary petition has been filed against Tenant under the
Bankruptcy Code that is not dismissed within thirty (30) days, or (D) the Lease has been rejected, or is deemed rejected, under Section 365 of the U.S. Bankruptcy Code, following the filing of a voluntary petition by Tenant under the
Bankruptcy Code, or the filing of an involuntary petition against Tenant under the Bankruptcy Code, or (E) the Bank has notified Landlord that the L-C will not be renewed or extended through the L-C Expiration Date, and Tenant has not provided a replacement L-C that satisfies the requirements of this First Amendment and the Lease at least thirty (30) days prior
to such expiration, or (F) Tenant is placed into receivership or conservatorship, or becomes subject to similar proceedings under Federal or State law, or (G) Tenant executes an assignment for the benefit of creditors, or (H) if
(1) any of the Bank’s Fitch Ratings (or other comparable ratings to the extent the Fitch Ratings are no longer available) have been reduced below the Bank’s Credit Rating Threshold, or (2) there is otherwise a material
adverse change in the financial condition of the Bank, and Tenant has failed to provide Landlord with a replacement letter of credit, conforming in all respects to the requirements of this Section 9 (including, but not
limited to, the requirements placed on the issuing Bank more particularly set forth in this Section 9.2 above), in the amount of the applicable L-C Amount, within ten (10)
business days following Landlord’s written demand therefor (with no other notice or cure or grace period being applicable thereto, notwithstanding anything in the Lease to the contrary) (each of the foregoing being an “L-C Draw Event”). The L-C shall be honored by the Bank regardless of whether Tenant disputes Landlord’s right to draw upon the
L-C. In addition, in the event the Bank is placed into receivership or conservatorship by the Federal Deposit Insurance Corporation or any successor or similar entity, then, effective as of the date such
receivership or conservatorship occurs, said L-C shall be deemed to fail to meet the requirements of this Section 9, and, within ten (10) business days following Landlord’s
notice to Tenant of such receivership or conservatorship (the “L-C FDIC Replacement Notice”), Tenant shall replace such L-C with a substitute
letter of credit from a different issuer (which issuer shall meet or exceed the Bank’s Credit Rating Threshold and shall otherwise be acceptable to Landlord in its reasonable discretion) and that complies in all respects with the requirements
of this Section 9. If Tenant fails to replace such L-C with such conforming, substitute letter of credit pursuant to the terms and conditions of this
Section 9.2, then, notwithstanding anything in the Lease to the contrary, Landlord shall have the right to declare Tenant in default of the Lease for which there shall be no notice or grace or cure periods being applicable
thereto (other than the aforesaid ten (10) business day period). Tenant shall be responsible for the payment of any and all Tenant’s and Bank’s costs incurred with the review of any replacement
L-C, which replacement is required pursuant to this Section or is otherwise requested by Tenant. In the event of an assignment by Tenant of its interest in the Lease (and

  
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irrespective of whether Landlord’s consent is required for such assignment), the acceptance of any replacement or substitute letter of credit by Landlord from the assignee shall be subject
to Landlord’s prior written approval, in Landlord’s reasonable discretion, and the actual and reasonable attorney’s fees incurred by Landlord in connection with such determination shall be payable by Tenant to Landlord within ten
(10) days of billing. 
 9.3 Application of L-C. Tenant
hereby acknowledges and agrees that Landlord is entering into the Lease in material reliance upon the ability of Landlord to draw upon the L-C upon the occurrence of any
L-C Draw Event. In the event of any L-C Draw Event, Landlord may, but without obligation to do so, and without notice to Tenant (except in connection with an L-C Draw Event under Section 9.2(H) above), draw upon the L-C, in part or in whole, in the amount necessary to cure any such L-C Draw Event and/or to compensate Landlord for any and all damages of any kind or nature sustained or which Landlord reasonably estimates that it will sustain resulting from Tenant’s breach or default of the
Lease or other L-C Draw Event and/or to compensate Landlord for any and all damages arising out of, or incurred in connection with, the termination of the Lease, including, without limitation, those
specifically identified in Section 1951.2 of the California Civil Code. The use, application or retention of the L-C, or any portion thereof, by Landlord shall not prevent Landlord from exercising any
other right or remedy provided by the Lease or by any applicable law, it being intended that Landlord shall not first be required to proceed against the L-C, and such
L-C shall not operate as a limitation on any recovery to which Landlord may otherwise be entitled. Tenant agrees and acknowledges that (i) the L-C constitutes a
separate and independent contract between Landlord and the Bank, (ii) Tenant is not a third party beneficiary of such contract, (iii) Tenant has no property interest whatsoever in the L-C or the
proceeds thereof, and (iv) in the event Tenant becomes a debtor under any chapter of the Bankruptcy Code, Tenant is placed into receivership or conservatorship, and/or there is an event of a receivership, conservatorship or a bankruptcy filing
by, or on behalf of, Tenant, neither Tenant, any trustee, nor Tenant’s bankruptcy estate shall have any right to restrict or limit Landlord’s claim and/or rights to the L-C and/or the proceeds
thereof by application of Section 502(b)(6) of the U. S. Bankruptcy Code or otherwise. 
 9.4 Maintenance of L-C by Tenant. If, as a result of any drawing by Landlord of all or any portion of the L-C, the amount of the L-C shall be less
than the L-C Amount, Tenant shall, within five (5) business days thereafter, provide Landlord with additional letter(s) of credit in an amount equal to the deficiency, and any such additional letter(s) of
credit shall comply with all of the provisions of this Section 9. Tenant further covenants and warrants that it will neither assign nor encumber the L-C or any part thereof and that
neither Landlord nor its successors or assigns will be bound by any such assignment, encumbrance, attempted assignment or attempted encumbrance. Without limiting the generality of the foregoing, if the L-C
expires earlier than the L-C Expiration Date, Landlord will accept a renewal thereof (such renewal letter of credit to be in effect and delivered to Landlord, as applicable, not later than thirty
(30) days prior to the expiration of the L-C), which shall be irrevocable and automatically renewable as above provided through the L-C Expiration Date upon the
same terms as the expiring L-C or such other terms as may be acceptable to Landlord in its sole discretion. If Tenant exercises its option to extend the Lease Term then, not later than thirty (30) days
prior to the commencement of the Option Term, Tenant shall deliver to Landlord a new L C or certificate of renewal or extension evidencing the L-C Expiration Date as thirty (30) days after the
expiration of the Option Term. However, if the L-C is not timely renewed, or if Tenant fails to maintain the L-C in the amount and in accordance with

  
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the terms set forth in this Section 9, Landlord shall have the right to present the L-C to the Bank in accordance with the terms
of this Section 9, and the proceeds of the L-C may be applied by Landlord against any Rent payable by Tenant under the Lease that is not paid when due and/or to pay for all losses and
damages that Landlord has suffered or that Landlord reasonably estimates that it will suffer as a result of any breach or default by Tenant under the Lease. In the event Landlord elects to exercise its rights as provided above, (I) any unused
proceeds shall constitute the property of Landlord (and not Tenant’s property or, in the event of a receivership, conservatorship, or a bankruptcy filing by, or on behalf of, Tenant, property of such receivership, conservatorship or
Tenant’s bankruptcy estate) and need not be segregated from Landlord’s other assets, and (II) Landlord agrees to pay to Tenant within thirty (30) days after the L-C Expiration Date the
amount of any proceeds of the L-C received by Landlord and not applied against any Rent payable by Tenant under the Lease that was not paid when due or used to pay for any losses and/or damages suffered by
Landlord (or reasonably estimated by Landlord that it will suffer) as a result of any breach or default by Tenant under the Lease; provided, however, that if prior to the L-C Expiration Date a voluntary
petition is filed by Tenant, or an involuntary petition is filed against Tenant by any of Tenant’s creditors, under the Bankruptcy Code, then Landlord shall not be obligated to make such payment in the amount of the unused L-C proceeds until either all preference issues relating to payments under the Lease have been resolved in such bankruptcy or reorganization case or such bankruptcy or reorganization case has been dismissed. If
Landlord draws on the L-C due to Tenant’s failure to timely renew or provide a replacement L-C, such failure shall not be considered a default under the Lease and
Landlord shall return such cash proceeds upon Tenant’s presentation of a replacement L-C that satisfies the requirements of this First Amendment, subject to reasonable satisfaction of any preference risk
to Landlord. 
 9.5 Transfer and Encumbrance. The L-C shall also provide that Landlord
may, at any time and without notice to Tenant and without first obtaining Tenant’s consent thereto, transfer (one or more times) all or any portion of its interest in and to the L-C to another party,
person or entity, regardless of whether or not such transfer is from or as a part of the assignment by Landlord of its rights and interests in and to the Lease. In the event of a transfer of Landlord’s interest in under the Lease, Landlord
shall transfer the L-C, in whole or in part, to the transferee and thereupon Landlord shall, without any further agreement between the parties, be released by Tenant from all liability therefor, and it is
agreed that the provisions hereof shall apply to every transfer or assignment of the whole of said L-C to a new landlord. In connection with any such transfer of the L-C
by Landlord, Tenant shall, at Tenant’s sole cost and expense, execute and submit to the Bank such applications, documents and instruments as may be necessary to effectuate such transfer and, Tenant shall be responsible for paying the
Bank’s transfer and processing fees in connection therewith; provided that, Landlord shall have the right (in its sole discretion), but not the obligation, to pay such fees on behalf of Tenant, in which case Tenant shall reimburse Landlord
within ten (10) days after Tenant’s receipt of an invoice from Landlord therefor. 
 9.6
L-C Not a Security Deposit. Landlord and Tenant (1) acknowledge and agree that in no event or circumstance shall the L-C or any renewal thereof or
substitute therefor or any proceeds thereof be deemed to be or treated as a “security deposit” under any law applicable to security deposits in the commercial context, including, but not limited to, Section 1950.7 of the California
Civil Code, as such Section now exists or as it may be hereafter amended or succeeded (the “Security Deposit Laws”), (2) acknowledge and agree that the L-C (including any renewal thereof
or substitute therefor or any proceeds thereof) is not intended to serve as a security deposit, 

  
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and the Security Deposit Laws shall have no applicability or relevancy thereto, and (3) waive any and all rights, duties and obligations that any such party may now, or in the future will,
have relating to or arising from the Security Deposit Laws. Tenant hereby irrevocably waives and relinquishes the provisions of Section 1950.7 of the California Civil Code and any successor statute, and all other provisions of law, now or
hereafter in effect, which (x) establish the time frame by which a landlord must refund a security deposit under a lease, and/or (y) provide that a landlord may claim from a security deposit only those sums reasonably necessary to remedy
defaults in the payment of rent, to repair damage caused by a tenant or to clean the premises, it being agreed that Landlord may, in addition, claim those sums specified in this Section 9 and/or those sums reasonably
necessary to (a) compensate Landlord for any loss or damage caused by Tenant’s breach of the Lease, including any damages Landlord suffers following termination of the Lease, and/or (b) compensate Landlord for any and all damages
arising out of, or incurred in connection with, the termination of the Lease, including, without limitation, those specifically identified in Section 1951.2 of the California Civil Code. Tenant agrees not to interfere in any way with any
payment to Landlord of the proceeds of the L-C, either prior to or following a “draw” by Landlord of all or any portion of the L-C, regardless of whether any
dispute exists between Tenant and Landlord as to Landlord’s right to draw down all or any portion of the L-C. No condition or term of the Lease shall be deemed to render the
L-C conditional and thereby afford the Bank a justification for failing to honor a drawing upon such L-C in a timely manner. Tenant shall not request or instruct the
Bank of any L-C to refrain from paying sight draft(s) drawn under such L-C. 

9.7 Remedy for Improper Drafts. Tenant’s sole remedy in connection with the improper presentment or payment of sight drafts
drawn under any L-C shall be the right to obtain from Landlord a refund of the amount of any sight draft(s) that were improperly presented or the proceeds of which were misapplied, and reasonable actual out-of-pocket attorneys’ fees, provided that at the time of such refund, Tenant increases the amount of such L-C to the amount (if
any) then required under the applicable provisions of the Lease. Tenant acknowledges that the presentment of sight drafts drawn under any L-C, or the Bank’s payment of sight drafts drawn under such L-C, could not under any circumstances cause Tenant injury that could not be remedied by an award of money damages, and that the recovery of money damages would be an adequate remedy therefor. In the event Tenant
shall be entitled to a refund as aforesaid and Landlord shall fail to make such payment within ten (10) business days after demand, Tenant shall have the right to deduct the amount thereof from the next installment(s) of Base Rent. 

10. Judicial Reference. NOTWITHSTANDING ANY PROVISION TO THE CONTRARY CONTAINED IN THE LEASE, THE PARTIES HEREBY WAIVE, TO THE
FULLEST EXTENT PERMITTED BY APPLICABLE LAW, THE RIGHT TO TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF OR RELATING TO THE LEASE. IF THE JURY WAIVER PROVISIONS OF THE LEASE ARE NOT ENFORCEABLE UNDER CALIFORNIA LAW, THEN THE FOLLOWING PROVISIONS
SHALL APPLY. IT IS THE DESIRE AND INTENTION OF THE PARTIES TO AGREE UPON A MECHANISM AND PROCEDURE UNDER WHICH CONTROVERSIES AND DISPUTES ARISING OUT OF THE LEASE OR RELATED TO THE PREMISES WILL BE RESOLVED IN A PROMPT AND EXPEDITIOUS MANNER.
ACCORDINGLY, EXCEPT WITH RESPECT TO ACTIONS FOR UNLAWFUL OR FORCIBLE DETAINER OR WITH RESPECT TO THE PREJUDGMENT REMEDY OF ATTACHMENT, ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY 

  
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EITHER PARTY HERETO AGAINST THE OTHER (AND/OR AGAINST ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR SUBSIDIARIES OR AFFILIATED ENTITIES) ON ANY MATTERS WHATSOEVER ARISING OUT OF OR IN ANY WAY
CONNECTED WITH THE LEASE, TENANT’S USE OR OCCUPANCY OF THE PREMISES AND/OR ANY CLAIM OF INJURY OR DAMAGE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, SHALL BE HEARD AND RESOLVED BY A REFEREE UNDER THE PROVISIONS OF THE CALIFORNIA CODE OF
CIVIL PROCEDURE, SECTIONS 638 — 645.1, INCLUSIVE (AS SAME MAY BE AMENDED, OR ANY SUCCESSOR STATUTE(S) THERETO) (THE “REFEREE SECTIONS”). ANY FEE TO INITIATE THE JUDICIAL REFERENCE PROCEEDINGS AND ALL FEES CHARGED AND COSTS
INCURRED BY THE REFEREE SHALL BE PAID BY THE PARTY INITIATING SUCH PROCEDURE (EXCEPT THAT IF A REPORTER IS REQUESTED BY EITHER PARTY, THEN A REPORTER SHALL BE PRESENT AT ALL PROCEEDINGS WHERE REQUESTED AND THE FEES OF SUCH REPORTER – EXCEPT FOR
COPIES ORDERED BY THE OTHER PARTIES – SHALL BE BORNE BY THE PARTY REQUESTING THE REPORTER); PROVIDED HOWEVER, THAT ALLOCATION OF THE COSTS AND FEES, INCLUDING ANY INITIATION FEE, OF SUCH PROCEEDING SHALL BE ULTIMATELY DETERMINED IN ACCORDANCE
WITH SECTION 29.21 ABOVE. THE VENUE OF THE PROCEEDINGS SHALL BE IN THE COUNTY IN WHICH THE PREMISES ARE LOCATED. WITHIN TEN (10) DAYS OF RECEIPT BY ANY PARTY OF A WRITTEN REQUEST TO RESOLVE ANY DISPUTE OR CONTROVERSY PURSUANT TO THIS
SECTION 10, THE PARTIES SHALL AGREE UPON A SINGLE REFEREE WHO SHALL TRY ALL ISSUES, WHETHER OF FACT OR LAW, AND REPORT A FINDING AND JUDGMENT ON SUCH ISSUES AS REQUIRED BY THE REFEREE SECTIONS. IF THE PARTIES ARE UNABLE TO AGREE UPON A REFEREE
WITHIN SUCH TEN (10) DAY PERIOD, THEN ANY PARTY MAY THEREAFTER FILE A LAWSUIT IN THE COUNTY IN WHICH THE PREMISES ARE LOCATED FOR THE PURPOSE OF APPOINTMENT OF A REFEREE UNDER THE REFEREE SECTIONS. IF THE REFEREE IS APPOINTED BY THE COURT, THE
REFEREE SHALL BE A NEUTRAL AND IMPARTIAL RETIRED JUDGE WITH SUBSTANTIAL EXPERIENCE IN THE RELEVANT MATTERS TO BE DETERMINED, FROM JAMS, THE AMERICAN ARBITRATION ASSOCIATION OR SIMILAR MEDIATION/ARBITRATION ENTITY. THE PROPOSED REFEREE MAY BE
CHALLENGED BY ANY PARTY FOR ANY OF THE GROUNDS LISTED IN THE REFEREE SECTIONS. THE REFEREE SHALL HAVE THE POWER TO DECIDE ALL ISSUES OF FACT AND LAW AND REPORT HIS OR HER DECISION ON SUCH ISSUES, AND TO ISSUE ALL RECOGNIZED REMEDIES AVAILABLE AT LAW
OR IN EQUITY FOR ANY CAUSE OF ACTION THAT IS BEFORE THE REFEREE, INCLUDING AN AWARD OF ATTORNEYS’ FEES AND COSTS IN ACCORDANCE WITH THE LEASE. THE REFEREE SHALL NOT, HOWEVER, HAVE THE POWER TO AWARD PUNITIVE DAMAGES, NOR ANY OTHER DAMAGES WHICH
ARE NOT PERMITTED BY THE EXPRESS PROVISIONS OF THE LEASE, AND THE PARTIES HEREBY WAIVE ANY RIGHT TO RECOVER ANY SUCH DAMAGES. THE PARTIES SHALL BE ENTITLED TO CONDUCT ALL DISCOVERY AS PROVIDED IN THE CALIFORNIA CODE OF CIVIL PROCEDURE, AND THE
REFEREE SHALL OVERSEE DISCOVERY AND MAY ENFORCE ALL DISCOVERY ORDERS IN THE SAME MANNER AS ANY TRIAL COURT JUDGE, WITH RIGHTS TO REGULATE DISCOVERY AND TO ISSUE AND ENFORCE SUBPOENAS, PROTECTIVE ORDERS AND OTHER

  
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LIMITATIONS ON DISCOVERY AVAILABLE UNDER CALIFORNIA LAW. THE REFERENCE PROCEEDING SHALL BE CONDUCTED IN ACCORDANCE WITH CALIFORNIA LAW (INCLUDING THE RULES OF EVIDENCE), AND IN ALL REGARDS, THE
REFEREE SHALL FOLLOW CALIFORNIA LAW APPLICABLE AT THE TIME OF THE REFERENCE PROCEEDING. THE PARTIES SHALL PROMPTLY AND DILIGENTLY COOPERATE WITH ONE ANOTHER AND THE REFEREE, AND SHALL PERFORM SUCH ACTS AS MAY BE NECESSARY TO OBTAIN A PROMPT AND
EXPEDITIOUS RESOLUTION OF THE DISPUTE OR CONTROVERSY IN ACCORDANCE WITH THE TERMS OF THIS SECTION 10. IN THIS REGARD, THE PARTIES AGREE THAT THE PARTIES AND THE REFEREE SHALL USE BEST EFFORTS TO ENSURE THAT (A) DISCOVERY BE CONDUCTED FOR A
PERIOD NO LONGER THAN SIX (6) MONTHS FROM THE DATE THE REFEREE IS APPOINTED, EXCLUDING MOTIONS REGARDING DISCOVERY, AND (B) A TRIAL DATE BE SET WITHIN NINE (9) MONTHS OF THE DATE THE REFEREE IS APPOINTED. IN ACCORDANCE WITH
SECTION 644 OF THE CALIFORNIA CODE OF CIVIL PROCEDURE, THE DECISION OF THE REFEREE UPON THE WHOLE ISSUE MUST STAND AS THE DECISION OF THE COURT, AND UPON THE FILING OF THE STATEMENT OF DECISION WITH THE CLERK OF THE COURT, OR WITH THE JUDGE IF
THERE IS NO CLERK, JUDGMENT MAY BE ENTERED THEREON IN THE SAME MANNER AS IF THE ACTION HAD BEEN TRIED BY THE COURT. ANY DECISION OF THE REFEREE AND/OR JUDGMENT OR OTHER ORDER ENTERED THEREON SHALL BE APPEALABLE TO THE SAME EXTENT AND IN THE SAME
MANNER THAT SUCH DECISION, JUDGMENT, OR ORDER WOULD BE APPEALABLE IF RENDERED BY A JUDGE OF THE SUPERIOR COURT IN WHICH VENUE IS PROPER HEREUNDER. THE REFEREE SHALL IN HIS/HER STATEMENT OF DECISION SET FORTH HIS/HER FINDINGS OF FACT AND CONCLUSIONS
OF LAW. THE PARTIES INTEND THIS GENERAL REFERENCE AGREEMENT TO BE SPECIFICALLY ENFORCEABLE IN ACCORDANCE WITH THE CODE OF CIVIL PROCEDURE. NOTHING IN THIS SECTION 10 SHALL PREJUDICE THE RIGHT OF ANY PARTY TO OBTAIN PROVISIONAL RELIEF OR OTHER
EQUITABLE REMEDIES FROM A COURT OF COMPETENT JURISDICTION AS SHALL OTHERWISE BE AVAILABLE UNDER THE CODE OF CIVIL PROCEDURE AND/OR APPLICABLE COURT RULES. 

11. California Required Disclosures. For purposes of Section 1938 of the California Civil Code, Landlord hereby discloses
to Tenant, and Tenant hereby acknowledges, that the Project, Building and Premises have not undergone inspection by a Certified Access Specialist (CASp). As required by Section 1938(e) of the California Civil Code, Landlord hereby states as
follows: “A Certified Access Specialist (CASp) can inspect the subject premises and determine whether the subject premises comply with all of the applicable construction-related accessibility standards under state law. Although state law does
not require a CASp inspection of the subject premises, the commercial property owner or lessor may not prohibit the lessee or tenant from obtaining a CASp inspection of the subject premises for the occupancy or potential occupancy of the lessee or
tenant, if requested by the lessee or tenant. The parties shall mutually agree on the arrangements for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs necessary to
correct violations of construction-related accessibility standards within the premises.” In furtherance of the foregoing, Landlord and Tenant hereby agree as follows: (a) any CASp inspection requested by Tenant shall be conducted, at
Tenant’s sole cost and expense, by a CASp approved in advance by Landlord; and (b) pursuant 

  
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to the Lease, but subject to Section 10.2 thereof, Tenant, at its cost, is responsible for making any repairs within the Premises to correct violations of construction-related accessibility
standards; and, if anything done by or for Tenant in its use or occupancy of the Premises shall require repairs to the Building (outside the Premises) to correct violations of construction-related accessibility standards, then Tenant shall, at
Landlord’s option, either perform such repairs at Tenant’s sole cost and expense or reimburse Landlord upon demand, as Additional Rent, for the cost to Landlord of performing such repairs. Tenant’s obligations under this
Section 11 are subject to the limitations in Section 10.2 of the Lease. 
 12.
Miscellaneous Provisions. Landlord represents that there is no mortgage or deed of trust encumbering currently the Building. Tenant shall not be required to restore any Alterations or Tenant Improvements existing in the Premises as of
the date of this First Amendment. 
 13. No Further Modification; Conflict. Except as specifically set forth in this First
Amendment, all of the terms and provisions of the Lease shall remain unmodified and in full force and effect. In the event of a conflict between the terms of the Lease and this First Amendment, the terms of this First Amendment shall prevail.

 [SIGNATURES FOLLOW ON NEXT PAGE] 

  
 -12- 

 IN WITNESS WHEREOF, this First Amendment has been executed as of the day and year first above written. 

 

											
	LANDLORD:	 	 	 	TENANT:
			
	BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership	 		 	ORIC PHARMACEUTICALS, INC., a Delaware corporation
					
	By:	 	HCP-Pointe Grand, Incorporated	 		 	By:	 	/s/ Christian V. Kuhlen
		 	its general partner	 		 		 	Name: Christian V. Kuhlen
		 		 		 		 		 	Its: General Counsel
		 	By:	 	/s/ Scott R. Bohn	 		 		 	
		 		 	Name: Scott R. Bohn	 		 		 	
		 		 	Its: Senior Vice President	 		 		 	

  
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 EXHIBIT A 

OUTLINE OF EXPANSION PREMISES 
  

 
 EXHIBIT A 

  
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 EXHIBIT B 

TENANT WORK LETTER 

This Tenant Work Letter shall set forth the terms and conditions relating to the improvement of the Premises by Tenant following the execution
of this First Amendment, and is hereby incorporated by this reference into and forms a part of the Lease. Terms not defined herein shall have the meanings given to them in the Lease. 

SECTION 1 

CONDITION OF PREMISES 

Landlord and Tenant acknowledge that Tenant has been occupying the Premises pursuant to the Lease, and, therefore, except as specifically set
forth in this Tenant Work Letter, Tenant shall continue to accept the Existing Premises in its currently-existing, “as-is” condition. In addition, Tenant has had the opportunity to examine the
Expansion Premises and Tenant shall accept the Expansion Premises in its currently-existing, “as-is” condition, subject to Section 2 of this First Amendment. Except as otherwise specifically set
forth in the Lease, including in this Tenant Work Letter and the penultimate sentence of Section 1.1.1 of the Lease, which shall apply to the Tenant Improvements described herein, Landlord shall have no obligation to make
or pay for any improvements to the Premises or to provide or pay for any upgrades to the Buildings or any Building systems. 
 SECTION
2 
 TENANT IMPROVEMENTS 

2.1 Tenant Improvement Allowance. Commencing as of the date of this First Amendment, Tenant shall be entitled to an improvement
allowance (the “Tenant Improvement Allowance”) in the amount of $45.00 per rentable square foot of the Premises (i.e., $1,514,835.00) for the costs relating to the design and construction of Tenant’s improvements, refurbishment
work and other renovations to be performed by Tenant in the Premises or which are “Tenant Improvement Allowance Items,” as that term is defined in Section 2.2.1, below (collectively, the “Tenant
Improvements”). All Tenant Improvements that have been paid for with or reimbursed from the Tenant Improvement Allowance shall be deemed Landlord’s property under the terms of the Lease; provided, however, Landlord may, by written
notice to Tenant given concurrently with Landlord’s approval of the “Final Working Drawings”, as that term is defined in Section 3.3, below, require Tenant, prior to the end of the Lease Term, at
Tenant’s expense, to remove any portion of the Tenant Improvements and to repair any damage to the Premises and Building caused by such removal and return the affected portion of the Premises to a condition with removed systems components
capped, Building standard ceiling tiles in good condition, and sheet rock and floors patched and repaired to match existing conditions of the remainder of the Premises. Landlord approves in concept and shall not require Tenant to remove any of the
Tenant Improvements to the extent shown on the Space Plan attached hereto as Schedule 1. The Tenant Improvement Allowance may not be used by Tenant for the purchase or installation of furniture, fixtures or equipment (other than an
autoclave and glasswash), or for telephone or data cabling, or any other personal property. 
  

  
 EXHIBIT B 

-1- 

 2.2 Disbursement of the Tenant Improvement Allowance. 

2.2.1 Tenant Improvement Allowance Items. Except as otherwise set forth in this Tenant Work Letter, the Tenant Improvement
Allowance shall be disbursed by Landlord only for the following items and costs (collectively the “Tenant Improvement Allowance Items”) (and shall not be used for moving or relocation expenses, furniture, fixtures , signage (other
than legally required signage), data cabling or personal property): 
 2.2.1.1 Payment of all reasonable fees of the “Architect”
and the “Engineers,” as those terms are defined in Section 3.1 of this Tenant Work Letter, project management fees, including those payable to Project Management Advisors, Inc. (“PMA”), as
provided below, and payment of the fees incurred by Landlord for specialists (such as a structural engineer) if needed for the review of the “Approved Working Drawings,” as that term is defined in Section 3.5 of
this Tenant Work Letter, and Tenant’s reasonable third-party management fees; 
 2.2.1.2 The payment of plan check, permit and license
fees relating to construction of the Tenant Improvements; 
 2.2.1.3 The payment for all demolition and removal of existing improvements in
the Premises; 
 2.2.1.4 The cost of construction of the Tenant Improvements (including, without limitation, testing and inspection costs,
the costs of refurbishments, building materials, piping and parts and equipment and other similar expenses and labor charges), signage required by law, hoisting and trash removal costs, costs to purchase and install in the Premises equipment
customarily incorporated into laboratory improvements or laboratory utility systems, including, without limitation, UPS DI Systems, boilers, air compressors, glass/cage washers and autoclaves, painting, and contractors’ fees and general
conditions;); 
 2.2.1.5 The cost of any changes in the Buildings when such changes are required by the Approved Working Drawings
(including if such changes are due to the fact that such work is prepared on an unoccupied basis), such cost to include all direct architectural and/or engineering fees and expenses incurred in connection therewith; 

2.2.1.6 The cost of any changes to the Approved Working Drawings or Tenant Improvements required by all applicable building codes (the
“Code”); 
 2.2.1.7 Sales and use taxes; 

2.2.1.8 Costs expended by Landlord pursuant to Section 4.1.1 of this Tenant Work Letter, below; 

2.2.1.9 Insurance premiums required by this Work Letter. 

2.2.2 Disbursement of Tenant Improvement Allowance. During the design and construction of the Tenant Improvements, Landlord
shall make monthly disbursements of the Tenant Improvement Allowance, for Tenant Improvements for the benefit of Tenant and shall authorize the release of monies for the benefit of Tenant as follows. 

  
 EXHIBIT B 

-2- 

 2.2.2.1 Monthly Disbursements. On or before the fifth (5th) day of each
calendar month, during the design and construction of the Tenant Improvements (or such other date as Landlord may designate), Tenant shall deliver to Landlord: (i) a request for reimbursement of amounts paid to the “Contractor,” as
that term is defined in Section 4.1.1 of this Tenant Work Letter, approved by Tenant, in a form to be provided by Landlord, showing the schedule, by trade, of percentage of completion of the Tenant Improvements in the
Premises, detailing the portion of the work completed and the portion not completed; (ii) invoices from all of “Tenant’s Agents,” as that term is defined in Section 4.1.2 of this Tenant Work Letter, for
labor rendered and materials for the Premises; (iii) executed conditional and/or unconditional mechanic’s lien releases, as applicable, from all of Tenant’s Agents which shall comply with the appropriate provisions, as reasonably
determined by Landlord, of the California Civil Code; and (iv) all other information reasonably requested by Landlord. Within forty-five (45) days thereafter, Landlord shall deliver a check to Tenant made payable to Tenant in payment of
the lesser of: (A) the amounts so requested by Tenant as set forth in this Section 2.2.1, above, and (B) the balance of any remaining available portion of the Tenant Improvement Allowance, provided that Landlord
does not dispute any request for payment based on non-compliance of any work with the “Approved Working Drawings,” as that term is defined in Section 3.5 below, or due to
any substandard work. Landlord’s payment of such amounts shall not be deemed Landlord’s approval or acceptance of the work furnished or materials supplied as set forth in Tenant’s payment request. 

2.2.2.2 Final Deliveries. Following the completion of construction of the Tenant Improvements, Tenant shall deliver to Landlord
properly executed final mechanic’s lien releases in compliance with the California Civil Code from all of Tenant’s Agents, and a certificate certifying that the construction of the Tenant Improvements in the Premises has been substantially
completed. Tenant shall record a valid Notice of Completion in accordance with the requirements of Section 4.3 of this Tenant Work Letter. 

2.2.2.3 Other Terms. Landlord shall only be obligated to make disbursements from the Tenant Improvement Allowance to the extent
costs are incurred by Tenant for Tenant Improvement Allowance Items. All Tenant Improvement Allowance Items that have been paid for with or reimbursed from the Tenant Improvement Allowance shall be deemed Landlord’s property under the terms of
the Lease, as amended hereby. 
 2.2.2.4 Building Standards. The quality of Tenant Improvements shall be in keeping with the
existing improvements in the Premises. 
 2.2.2.5 Utilization of Allowance. Any portion of the Tenant Improvement Allowance
not utilized by Tenant on or before May 16, 2023, as such date may be extended by one (1) day for each day of delay by Tenant in completing the Tenant Improvements due to an event which qualifies as a Landlord Caused Delay (as defined in
Section 5.5.1 below) or Coronavirus Delay (as defined in Section 5.5.2 below), shall revert to Landlord and Tenant shall have no further rights with respect thereto. 

2.3 Failure to Disburse the Tenant Improvement Allowance. To the extent that Landlord fails to make payments from the Tenant
Improvement Allowance in accordance with the terms of this Tenant Work Letter, and such amounts remain unpaid for thirty (30) days after notice from Tenant, then without limiting Tenant’s other remedies under the Lease, Tenant may, after
Landlord’s failure to pay such amounts within five (5) business days after Tenant’s delivery of a second notice from Tenant delivered after the expiration of such 30-day period, pay the same and
deduct the amount thereof, together with interest at the interest rate set forth in Section 25, from 

  
 EXHIBIT B 

-3- 

 
the Rent next due and owning under the Lease. Notwithstanding the foregoing, if during either the 30-day or 5-day
period set forth above, Landlord (i) delivers notice to Tenant that it disputes any portion of the amounts claimed to be due (the “Allowance Dispute Notice”), and (ii) pays any amounts not in dispute, Tenant shall have no right
to offset any amounts against rent, but may institute proceedings to recover such amounts from Landlord. 
 SECTION 3 

CONSTRUCTION DRAWINGS 

3.1 Selection of Architect. Tenant shall retain an architect/space planner (the “Architect”) approved in
advance by Landlord (which approval shall not be unreasonably withheld) to prepare the Final Space Plan and Final Working Drawings as provided in Section 3.2 and 3.3, below. Landlord hereby approves CAC Architects or
DGA Architects as the Architect and Thornton Tomasetti as the Engineers. Tenant shall retain the engineering consultants or design/build subcontractors designated by Tenant and reasonably approved in advance by Landlord, which approval shall not be
unreasonably withheld, conditioned or delayed (the “Engineers”) to prepare all plans and engineering working drawings relating to the structural, mechanical, electrical, plumbing, HVAC, life-safety, and sprinkler work in the
Premises. All such plans and drawings shall comply with locally recognized engineering codes, applicable law and standards, and sound industry practices prevailing at the time of performance that are followed by architects or professional engineers
performing similar work under similar conditions, and shall be subject to Landlord’s reasonable approval, which approval shall not be unreasonably withheld, conditioned or delayed. Tenant and Architect shall verify, in the field, the dimensions
and conditions as shown on the relevant portions of the Base Building plans, and Tenant and Architect shall be solely responsible for the same, and Landlord shall have no responsibility in connection therewith. Landlord’s review of any plans or
drawings as set forth in this Section 3, shall be for its sole purpose and shall not imply Landlord’s review of the same, or obligate Landlord to review the same, for quality, design, Code compliance or other like
matters. 
 3.2 Final Space Plan. Tenant shall supply Landlord with four (4) copies signed by Tenant of its final space
plan for the Tenant Improvements before any architectural working drawings or engineering drawings have been commenced. The final space plan (“Final Space Plan”) shall include a layout and designation of all offices, labs, rooms and
other partitioning, their intended use, and equipment to be contained therein. Landlord may request clarification or more specific drawings for special use items not included in any Final Space Plan. Landlord shall advise Tenant within five
(5) business days after Landlord’s receipt of a Final Space Plan if the same is unsatisfactory or incomplete in any respect. If Tenant is so advised, Tenant shall promptly cause such Final Space Plan to be revised to correct any
deficiencies or other matters Landlord may reasonably require. Landlord hereby approves the space plan and scope of work attached hereto as Schedule 1 (the “Space Plan”), and will not withhold its consent to the aspects of the
working drawings to the extent set forth on the Space Plan. 
 3.3 Final Working Drawings. After the Final Space Plan has been
approved by Landlord, Tenant shall supply the Engineers with a complete listing of standard and non-standard equipment and specifications, including, without limitation, electrical requirements and special
electrical receptacle requirements for the relevant Phase of the Tenant Improvements, to enable 

  
 EXHIBIT B 

-4- 

 
the Engineers and the Architect to complete the “Final Working Drawings” (as that term is defined below) for the Premises in the manner as set forth below. Upon the approval of the
Final Space Plan by Landlord and Tenant, Tenant shall promptly cause the Architect and the Engineers to complete the architectural and engineering drawings for the relevant Phase, and Architect shall compile a fully coordinated set of architectural,
structural, mechanical, electrical and plumbing working drawings in a form which is sufficiently complete to allow all of Tenant’s Agents to bid on the work and to obtain all applicable permits (collectively, the “Final Working
Drawings”) and shall submit the same to Landlord for Landlord’s approval, which shall not be unreasonably withheld, conditioned, or delayed. Tenant shall supply Landlord with four (4) copies signed by Tenant of such Final Working
Drawings. Landlord shall advise Tenant within five (5) business days after Landlord’s receipt of the Final Working Drawings if the same is unsatisfactory or incomplete in any respect (provided that, if the scope of such Final Working
Drawings are such that Landlord cannot reasonably complete its review in such period, Landlord will inform Tenant, and such period will be extended five (5) additional business days). If Tenant is so advised, Tenant shall promptly cause the
Final Working Drawings to be revised in accordance with such review and any disapproval of Landlord in connection therewith. If Landlord fails to respond to any requests within the specified period, Tenant may deliver Landlord a reminder notice, and
if Landlord fails to respond within two (2) business days after receipt of the reminder notice, such request shall be deemed approved. 

3.4 Approved Working Drawings. The Final Working Drawings shall be approved by Landlord (the “Approved Working
Drawings”) prior to the commencement of construction of such Phase by Tenant. Concurrently with Tenant’s delivery of the Final Working Drawings to Landlord for Landlord’s approval, Tenant may submit the same to the appropriate
municipal authorities for all applicable building permits. Tenant hereby agrees that neither Landlord nor Landlord’s consultants shall be responsible for obtaining any building permit or certificate of occupancy for the Premises and that
obtaining the same shall be Tenant’s responsibility; provided, however, that Landlord shall cooperate with Tenant in executing permit applications and performing other ministerial acts reasonably necessary to enable Tenant to obtain any such
permit or certificate of occupancy. No changes, modifications or alterations in any Approved Working Drawings may be made without the prior written consent of Landlord, which shall not be unreasonably withheld, conditioned, or delayed. 

SECTION 4 

CONSTRUCTION OF THE TENANT IMPROVEMENTS 

4.1 Tenant’s Selection of Contractors. 

4.1.1 The Contractor; Landlord’s Project Manager. Tenant shall retain a licensed general contractor, approved in advance by
Landlord, to construct the Tenant Improvements (“Contractor”). Landlord’s approval of the Contractor shall not be unreasonably withheld, conditioned or delayed. Landlord hereby approves Landmark Builders or MCS Construction as
the Contractor. Landlord shall retain Project Management Advisors, Inc. (“PMA”) as a third party project manager for construction oversight of the Tenant Improvements on behalf of Landlord, and Tenant shall pay a fee to Landlord
with respect to the PMA services, equal to $1.73 per RSF of the Premises in which the Tenant Improvements are performed. The PMA fee shall be a Tenant Improvement Allowance Item payable by Landlord from the Tenant Improvement Allowance. 

  
 EXHIBIT B 

-5- 

 4.1.2 Tenant’s Agents. All subcontractors, laborers, materialmen, and
suppliers used by Tenant shall be known collectively as “Tenant’s Agents”. The subcontractors used by Tenant, but not any laborers, materialmen, and suppliers, must be approved in writing by Landlord, which approval shall not
be unreasonably withheld, conditioned, or delayed; provided, however, Landlord may require Tenant to select from a list of particular mechanical, engineering, plumbing, fire life-safety and other Base Building subcontractors, provided that Tenant
shall have the final decision regarding the selection of the subcontractor from the approved list. The subcontractors set forth on Schedule 2 are hereby pre-approved by Landlord with respect to
the respective trades. If Landlord does not approve of any of Tenant’s proposed subcontractors, Tenant shall submit the names of other proposed subcontractors for Landlord’s written approval, which approval shall not be unreasonably
withheld, conditioned or delayed. 
 4.2 Construction of Tenant Improve by Tenant’s Agents. 

4.2.1 Construction Contract; Cost Budget. Tenant shall engage the Contractor under a commercially reasonable and customary
construction contract (collectively, the “Contract”). Prior to the commencement of the construction of any Phase of the Tenant Improvements, and after Tenant has accepted all bids for the Tenant Improvements, Tenant shall provide
Landlord with a detailed breakdown, by trade, of the final costs to be incurred or which have been incurred in connection with the design and construction of the relevant Phase of the Tenant Improvements to be performed by or at the direction of
Tenant or the Contractor, which costs form a basis for the estimated total costs of the work of the relevant Phase of the Tenant Improvements (each, a “Final Budget”). Any costs of design and construction of the Tenant Improvements
in excess of the Tenant Improvement Allowance shall be paid by Tenant out of its own funds once the Tenant Improvement Allowance is exhausted, but Tenant shall continue to provide Landlord with the documents described in
Sections 2.2.2.1(i), (ii), (iii) and (iv) of this Tenant Work Letter, above, for Landlord’s approval, prior to Tenant paying such costs. 

4.2.2 Tenant’s Agents. 

4.2.2.1 Compliance with Drawings and Schedule. Tenant’s and Tenant’s Agent’s construction of the Tenant
Improvements shall comply with the following: (i) the Tenant Improvements shall be constructed in strict accordance with the relevant Approved Working Drawings; and (ii) Tenant’s Agents shall submit schedules of all work relating to
Tenant’s Improvements to Contractor and Contractor shall, within five (5) business days of receipt thereof, inform Tenant’s Agents of any changes which are necessary thereto, and Tenant’s Agents shall use commercially reasonable
efforts to adhere to such corrected schedule. 
 4.2.2.2 Indemnity. Tenant’s indemnity of Landlord as set forth in
Article 10 of the Lease shall also apply with respect to any and all costs, losses, damages, injuries and liabilities related in any way to any act or omission of Tenant or Tenant’s Agents, or anyone directly or indirectly employed by
any of them, or in connection with Tenant’s non-payment of any amount arising out of the Tenant Improvements and/or Tenant’s disapproval of all or any portion of any request for payment. The
foregoing indemnity shall not apply to claims caused by the gross negligence or willful misconduct of Landlord, its member partners, shareholders, officers, directors, agents, employees, and/or contractors, or Landlord’s violation of the Lease.

  
 EXHIBIT B 

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 4.2.2.3 Requirements of Tenant’s Agents. Each of Tenant’s Agents
shall guarantee to Tenant and for the benefit of Landlord that the portion of the Tenant Improvements for which it is responsible shall be free from any defects in workmanship and materials for a period of not less than one (1) year from the
date of substantial completion of the work under the relevant Contract (“Substantial Completion”). Each of Tenant’s Agents shall be responsible for the replacement or repair, without additional charge, of all work done or
furnished in accordance with its contract that shall become defective within one (1) year after Substantial Completion. The correction of such work shall include, without additional charge, all additional expenses and damages incurred in
connection with such removal or replacement of all or any part of the Tenant Improvements, and/or the Building and/or common areas that may be damaged or disturbed thereby. All such warranties or guarantees as to materials or workmanship of or with
respect to the Tenant Improvements shall be contained in the relevant Contract or subcontract and shall be written such that such guarantees or warranties shall inure to the benefit of both Landlord and Tenant, as their respective interests may
appear, and can be directly enforced by either. Tenant covenants to give to Landlord any assignment or other assurances which may be necessary to provide for such right of direct enforcement. 

4.2.2.4 Insurance Requirements. 

4.2.2.4.1 General Coverages. All of Tenant’s Agents shall carry the following insurance provided by insurers with an A.M.
Best rating of A- VIII or better: (1) worker’s compensation insurance covering all of their respective employees with a waiver of subrogation in favor of Landlord and Landlord’s Representative,
and (2) commercial general liability insurance, including contractual and products/completed operations coverage with a limit not less than $1,000,000 per occurrence/$2,000,000 aggregate, Tenant shall require the Agents’ commercial general
liability insurance policies name Landlord and Landlord’s and Landlord’s Representative as additional insureds with respect to the work being done under this Tenant Work Letter. 

4.2.2.4.2 Special Coverages. If the total cost of the work to be done is $500,000 or more, Tenant shall carry
“Builder’s All Risk” insurance covering the construction of the Tenant Improvements in an amount equal to the total of the hard and soft costs of such work, and such other insurance as Landlord may require, it being understood and
agreed that the Tenant Improvements shall be insured by Landlord pursuant to the Lease, immediately upon completion thereof. 
 4.2.2.4.3
General Terms. Certificates for all insurance carried pursuant to this Section 4.2.2.4 shall be delivered to Landlord before the commencement of construction of the Tenant Improvements and before the
Contractor’s equipment is moved onto the site. Should any policies expire during the time work is being done under this agreement, a renewal certificate shall be delivered to Landlord prior to the expiration date on such policy. All such
policies of insurance must contain a provision that the company writing said policy will endeavor to give Landlord thirty (30) days prior written notice of any cancellation or lapse of the effective date or any reduction in the amounts of such
insurance. Tenant shall provide Landlord 

  
 EXHIBIT B 

-7- 

 
notice of any cancellation or lapse of the effective date or reduction in the amounts of such insurance promptly following Tenant’s receipt of such notice from its insurer. Tenant’s
Agents shall maintain all of the foregoing insurance coverage in force until the Tenant Improvements are fully completed and accepted by Landlord,. All policies carried under this Section 4.2.2.3, except workers
compensation, shall insure Landlord and Tenant, as their interests may appear, as well as Contractor and Tenant’s Agents, and “Landlord’s Representative”, as that term is defined below. All insurance maintained by Tenant’s
Agents shall preclude subrogation claims by the insurer against anyone insured thereunder. All such insurance required of tenant and its Agents shall provide that it is primary insurance as respects the owner and Landlord’s Representative and
that any other insurance maintained by owner is excess and noncontributing with the insurance required hereunder. The requirements for the foregoing insurance shall not derogate from the provisions for indemnification of Landlord by Tenant under
Section 4.2.2.2 of this Tenant Work Letter. If the Over-Allowance Amount is more than fifty percent (50%) of the total amount of the Tenant Improvement Allowance, then Landlord may, in its reasonable discretion,
require Tenant to obtain a lien and completion bond or some alternate form of security satisfactory to Landlord in an amount sufficient to ensure the lien-free completion of the Tenant Improvements and naming Landlord as a co-obligee. 
 4.2.3 Governmental Compliance. The Tenant Improvements shall comply in all
respects with the following: (i) all state, federal, city or quasi-governmental laws, codes, ordinances and regulations, as each may apply according to the rulings of the controlling public official, agent or other person; (ii) applicable
standards of the American Insurance Association (formerly, the National Board of Fire Underwriters) and the National Electrical Code; and (iii) building material manufacturer’s specifications. 

4.2.4 Inspection by Landlord. Landlord shall have the right to inspect the Tenant Improvements at all times, provided however,
that Landlord’s failure to inspect the Tenant Improvements shall in no event constitute a waiver of any of Landlord’s rights hereunder nor shall Landlord’s inspection of the Tenant Improvements constitute Landlord’s approval of
the same. Should Landlord reasonably disapprove any portion of the Tenant Improvements, on the grounds that the construction is defective or fails to comply with the Approved Working Drawings, Landlord shall notify Tenant in writing of such
disapproval and shall specify the items disapproved. Any such defects or deviations shall be rectified by Tenant at no expense to Landlord, provided however, that in the event that a defect or deviation exists that materially adversely affects the
mechanical, electrical, plumbing, heating, ventilating and air conditioning or life-safety systems of the Buildings, the Building structure or exterior appearance of the Building, or any other tenant’s use of such other tenant’s leased
premises, Landlord may, take such action as Landlord reasonably deems necessary, at Tenant’s expense and without incurring any liability on Landlord’s part, to correct any such defect, deviation and/or matter, including, without
limitation, causing the cessation of performance of the construction of the Tenant Improvements until such time as the defect, deviation and/or matter is corrected to Landlord’s reasonable satisfaction. 

4.2.5 Meetings. Commencing upon the date Tenant begins to plan any phase of the Tenant Improvements, Tenant shall hold weekly
meetings at a reasonable time, with the Architect and the Contractor (once retained) regarding the progress of the preparation of Construction Drawings and the construction of the Tenant Improvements, and Landlord and/or its agents shall receive
prior notice of, and shall have the right to attend, all such meetings, and, upon Landlord’s request, certain of Tenant’s Agents shall attend such meetings. In addition, minutes shall be taken at all such meetings, a copy of which minutes
shall be promptly delivered to Landlord. One such meeting each month shall include the review of Contractor’s current request for payment, if any. 

  
 EXHIBIT B 

-8- 

 4.3 Notice of Completion; Copy of Record Set of Plans. Within ten
(10) days after completion of construction of each Phase of the Tenant Improvements, Tenant shall cause a valid Notice of Completion to be recorded in the office of the Recorder of the county in which the Buildings are located in accordance
with the Civil Code of the State of California, and shall furnish a copy thereof to Landlord upon such recordation. If Tenant fails to do so, Landlord may execute and file the same on behalf of Tenant as Tenant’s agent for such purpose, at
Tenant’s sole cost and expense. At the conclusion of construction of each Phase of the Tenant Improvements, (i) Tenant shall cause the relevant Architect and Contractor (x) to update the relevant Approved Working Drawings as necessary
to reflect all changes made to the Approved Working Drawings during the course of construction of the relevant Phase, (y) to certify to the best of their knowledge that the “record-set” of as-built drawings are true and correct, which certification shall survive the expiration or termination of the Lease, as hereby amended, and (z) to deliver to Landlord two (2) sets of copies of such record
set of drawings (hard copy and electronic files) within ninety (90) days following Substantial Completion, and (ii) Tenant shall deliver to Landlord a copy of all warranties, guaranties, and operating manuals and information relating to
the improvements, equipment, and systems in the Premises. Within fifteen (15) days after request by Tenant following the Substantial Completion of each Phase of the Tenant Improvements, Landlord will acknowledge its approval of the relevant
Phase of the Tenant Improvements (provided that such approval has been granted) by placing its signature on the relevant Contractor’s Certificate of Substantial Completion fully executed by the relevant Architect, the relevant Contractor and
Tenant. Landlord’s approval shall not create any contingent liabilities for Landlord with respect to any latent quality, design, Code compliance or other like matters that may arise subsequent to Landlord’s approval. 

SECTION 5 

MISCELLANEOUS 
 5.1
Tenant’s Representative. Tenant hereby designates Dominic Piscitelli as its sole representative with respect to the matters set forth in this Tenant Work Letter, and Tenant may designate an additional or replacement representative
in a written notice to Landlord, and such representatives shall each have full authority and responsibility to act on behalf of the Tenant as required in this Tenant Work Letter. 

5.2 Landlord’s Representative. Landlord has designated Project Management Advisors, Inc., as its sole representatives with
respect to the matters set forth in this Tenant Work Letter, who, until further notice to Tenant, shall have full authority and responsibility to act on behalf of the Landlord as required in this Tenant Work Letter. 

5.3 Time is of the Essence in This Tenant Work Letter. Unless otherwise indicated, all references herein to a “number of
days” shall mean and refer to calendar days. If any item requiring approval is timely disapproved by Landlord, the procedure for preparation of the document and approval thereof shall be repeated until the document is approved by Landlord. 

  
 EXHIBIT B 

-9- 

 5.4 Tenant’s Lease Default. Notwithstanding any provision to the contrary
contained in the Lease or this Tenant Work Letter, if any default by Tenant under the Lease or this Tenant Work Letter occurs at any time on or before the substantial completion of the Tenant Improvements and such default remains uncured ten
(10) days following Landlord’s notice of such default to Tenant, then in addition to all other rights and remedies granted to Landlord pursuant to the Lease, Landlord shall have the right to withhold payment of all or any portion of the
Tenant Improvement Allowance. 
 5.5 Delays. 

5.5.1 Landlord Caused Delay. As used herein, “Landlord Caused Delay” shall mean actual delays in the
substantial completion of the applicable portion of the Premises to the extent resulting from interference (when judged in accordance with industry custom and practice) with Tenant’s construction of the Tenant Improvements to the extent caused
by (i) Landlord’s failure to timely approve or disapprove any matter requiring Landlord’s approval pertaining to the Tenant Improvements within the time periods set forth above or if not specified, within a reasonable period of time;
(ii) Landlord’s failure to timely disburse the Tenant Improvement Allowance; or (iii) material and unreasonable interference by Landlord with substantial completion of the applicable portion of the Premises if such interference
(A) objectively precludes or delays the construction of Tenant Improvements therein or any portion thereof, and (B) relates to access by Tenant to the applicable portion of the Premises or any of the Building’s facilities (including
loading docks and freight elevators) or services and utilities (including temporary power and parking areas as provided herein) during normal construction hours, or the use thereof during normal construction hours. If Tenant contends that a Landlord
Caused Delay has occurred, Tenant shall notify Landlord in writing of the event which constitutes such Landlord Caused Delay. Tenant will additionally use reasonable efforts to mitigate the effects of any Landlord Caused Delay through the re-sequencing or re-scheduling of work, if feasible, but this sentence will not be deemed to require Tenant to incur overtime or after-hours costs unless Landlord agrees in
writing to bear such costs. In addition, Tenant shall endeavor to provide notice to Landlord when Tenant becomes aware of any expected or potential Landlord Caused Delays prior to any such delay actually occurring, in order to allow Landlord to
attempt to mitigate such potential delay. If such actions, inaction or circumstance described in the notice (the “Landlord Delay Notice”) are not cured by Landlord within one (1) business day of Landlord’s receipt of the
Landlord Delay Notice and if such action, inaction or circumstance otherwise qualify as a Landlord Caused Delay, then a Landlord Caused Delay shall be deemed to have occurred commencing as of the date of Landlord’s receipt of the Landlord Delay
Notice and ending as of the date such delay ends. 
 5.5.2 Coronavirus Delay. The term “Coronavirus Delay”
shall mean only an actual delay in the completion of the Tenant Improvements which is caused by (x) suspension of construction of the Tenant Improvements affecting all similar construction in the vicinity of the Building due to any law,
regulation, ordinance, rule, requirement or order of any governmental authority which may hereafter be adopted or imposed to address the COVID-19 outbreak, (y) delay in the response of any governmental
authority to Tenant’s initial submittal of construction drawings for the Improvements, or any subsequent submittals thereof, beyond thirty (30) days after 

  
 EXHIBIT B 

-10- 

 
such submittal, if such response delays arise as a result of the COVID-19 pandemic and the effects thereof; or (z) delay in the issuance of a building
permit beyond thirty (30) days after Tenant’s initial request for issuance or delay in the issuance of a temporary certificate of occupancy or certificate of occupancy permitting Tenant to occupy the applicable portion of the Premises
beyond thirty (30) days after final inspection of the applicable portion of the Premises, or delay in performing any required inspections beyond thirty (30) days after Tenant’s request for such inspection, to the extent such issuance
delay arises as a result of the COVID-19 pandemic and the effects thereof. In order for Tenant to claim any Coronavirus Delay, Tenant must notify Landlord in writing (each, a “Coronavirus Delay
Notice”) specifying the nature of the Coronavirus Delay and the anticipated number of days of Coronavirus Delay. 

  
 EXHIBIT B 

-11- 

 SCHEDULE 1 

SPACE PLAN 
  

 

  
 SCHEDULE 1 

-1- 

 SCHEDULE 2 

Mechanical 
  

	 	•	 	 Therma 

  

	 	•	 	 United Mechanical 

  

	 	•	 	 Western Allied Mechanical 

Electrical 
  

	 	•	 	 Cupertino Electric 

  

	 	•	 	 Foley Electric 

  

	 	•	 	 Howell Electric 

  

	 	•	 	 Morrow Meadows 

  

	 	•	 	 Serrano Electric 

  

	 	•	 	 TL Electric 

Plumbing 
  

	 	•	 	 KDS Plumbing 

  

	 	•	 	 Therma 

  
 SCHEDULE 2 

-1- 

 EXHIBIT C 

(Letterhead of a money center bank 

acceptable to the Landlord) 
  

			
	FAX NO. [(___) ___-____]
SWIFT: [Insert No., if any]	  	[Insert Bank Name And Address]
		
	 	  	DATE OF ISSUE:
		
	BENEFICIARY:
[Insert Beneficiary Name And Address]	  	APPLICANT:
[Insert Applicant Name And Address]
		
	 	  	LETTER OF CREDIT NO.
		
	EXPIRATION DATE:
                            AT OUR COUNTERS	  	AMOUNT AVAILABLE:
USD[Insert Dollar Amount]
(U.S. DOLLARS [Insert Dollar Amount])

 LADIES AND GENTLEMEN: 
 WE HEREBY
ESTABLISH OUR IRREVOCABLE STANDBY LETTER OF CREDIT NO. ___________ IN YOUR FAVOR FOR THE ACCOUNT OF [Insert Tenant’s Name], A [Insert Entity Type], UP TO THE AGGREGATE AMOUNT OF USD[Insert Dollar Amount] ([Insert Dollar Amount] U.S.
DOLLARS) EFFECTIVE IMMEDIATELY AND EXPIRING ON ___(Expiration Date)___ AVAILABLE BY PAYMENT UPON PRESENTATION OF YOUR DRAFT AT SIGHT DRAWN ON [Insert Bank Name] WHEN ACCOMPANIED BY THE FOLLOWING DOCUMENT(S): 

1.    THE ORIGINAL OF THIS IRREVOCABLE STANDBY LETTER OF CREDIT AND AMENDMENT(S), IF ANY. 

2.    BENEFICIARY’S SIGNED STATEMENT PURPORTEDLY SIGNED BY AN AUTHORIZED REPRESENTATIVE OF [Insert Landlord’s
Name], A [Insert Entity Type] (“LANDLORD”) STATING THE FOLLOWING: 
 “THE UNDERSIGNED HEREBY CERTIFIES THAT THE LANDLORD,
EITHER (A) UNDER THE LEASE (DEFINED BELOW), OR (B) AS A RESULT OF THE TERMINATION OF SUCH LEASE, HAS THE RIGHT TO DRAW DOWN THE AMOUNT OF USD      IN ACCORDANCE WITH THE TERMS OF THAT CERTAIN OFFICE LEASE DATED
[Insert Lease Date], AS AMENDED (COLLECTIVELY, THE “LEASE”), OR SUCH AMOUNT CONSTITUTES DAMAGES OWING BY THE TENANT TO BENEFICIARY RESULTING FROM THE BREACH OF SUCH LEASE BY THE TENANT THEREUNDER, OR THE TERMINATION OF SUCH LEASE, AND SUCH
AMOUNT REMAINS UNPAID AT THE TIME OF THIS DRAWING.” 

  
 EXHIBIT C 

-2- 

 OR 

“THE UNDERSIGNED HEREBY CERTIFIES THAT WE HAVE RECEIVED A WRITTEN NOTICE OF [Insert Bank Name]‘S ELECTION NOT TO EXTEND ITS STANDBY
LETTER OF CREDIT NO. ___________ AND HAVE NOT RECEIVED A REPLACEMENT LETTER OF CREDIT WITHIN AT LEAST THIRTY (30) DAYS PRIOR TO THE PRESENT EXPIRATION DATE.” 

OR 
 “THE UNDERSIGNED HEREBY CERTIFIES THAT
BENEFICIARY IS ENTITLED TO DRAW DOWN THE FULL AMOUNT OF LETTER OF CREDIT NO. ___________ AS THE RESULT OF THE FILING OF A VOLUNTARY PETITION UNDER THE U.S. BANKRUPTCY CODE OR A STATE BANKRUPTCY CODE BY THE TENANT UNDER THAT CERTAIN OFFICE LEASE
DATED [Insert Lease Date], AS AMENDED (COLLECTIVELY, THE “LEASE”), WHICH FILING HAS NOT BEEN DISMISSED AT THE TIME OF THIS DRAWING.” 
 OR

 “THE UNDERSIGNED HEREBY CERTIFIES THAT BENEFICIARY IS ENTITLED TO DRAW DOWN THE FULL AMOUNT OF LETTER OF CREDIT NO. ___________
AS THE RESULT OF AN INVOLUNTARY PETITION HAVING BEEN FILED UNDER THE U.S. BANKRUPTCY CODE OR A STATE BANKRUPTCY CODE AGAINST THE TENANT UNDER THAT CERTAIN OFFICE LEASE DATED [Insert Lease Date], AS AMENDED (COLLECTIVELY, THE “LEASE”),
WHICH FILING HAS NOT BEEN DISMISSED AT THE TIME OF THIS DRAWING.” 
 OR 

“THE UNDERSIGNED HEREBY CERTIFIES THAT BENEFICIARY IS ENTITLED TO DRAW DOWN THE FULL AMOUNT OF LETTER OF CREDIT NO. ________________ AS
THE RESULT OF THE REJECTION, OR DEEMED REJECTION, OF THAT CERTAIN OFFICE LEASE DATED [Insert Lease Date], AS AMENDED, UNDER SECTION 365 OF THE U.S. BANKRUPTCY CODE.” 

  
 EXHIBIT C 

-2- 

 SPECIAL CONDITIONS: 

PARTIAL DRAWINGS AND MULTIPLE PRESENTATIONS MAY BE MADE UNDER THIS STANDBY LETTER OF CREDIT, PROVIDED, HOWEVER, THAT EACH SUCH DEMAND THAT IS PAID BY US SHALL
REDUCE THE AMOUNT AVAILABLE UNDER THIS STANDBY LETTER OF CREDIT. 
 ALL INFORMATION REQUIRED WHETHER INDICATED BY BLANKS, BRACKETS OR OTHERWISE, MUST BE
COMPLETED AT THE TIME OF DRAWING. [Please Provide The Required Forms For Review, And Attach As Schedules To The Letter Of Credit.] 
 ALL SIGNATURES MUST BE
MANUALLY EXECUTED IN ORIGINALS. 
 ALL BANKING CHARGES ARE FOR THE APPLICANT’S ACCOUNT. 

IT IS A CONDITION OF THIS STANDBY LETTER OF CREDIT THAT IT SHALL BE DEEMED AUTOMATICALLY EXTENDED WITHOUT AMENDMENT FOR A PERIOD OF ONE YEAR FROM THE PRESENT
OR ANY FUTURE EXPIRATION DATE, UNLESS AT LEAST SIXTY (60) DAYS PRIOR TO THE EXPIRATION DATE WE SEND YOU NOTICE BY NATIONALLY RECOGNIZED OVERNIGHT COURIER SERVICE THAT WE ELECT NOT TO EXTEND THIS LETTER OF CREDIT FOR ANY SUCH ADDITIONAL PERIOD.
SAID NOTICE WILL BE SENT TO THE ADDRESS INDICATED ABOVE, UNLESS A CHANGE OF ADDRESS IS OTHERWISE NOTIFIED BY YOU TO US IN WRITING BY RECEIPTED MAIL OR COURIER. ANY NOTICE TO US WILL BE DEEMED EFFECTIVE ONLY UPON ACTUAL RECEIPT BY US AT OUR
DESIGNATED OFFICE. IN NO EVENT, AND WITHOUT FURTHER NOTICE FROM OURSELVES, SHALL THE EXPIRATION DATE BE EXTENDED BEYOND A FINAL EXPIRATION DATE OF ___ (120 days from the Lease Expiration Date). 

THIS LETTER OF CREDIT MAY BE TRANSFERRED SUCCESSIVELY IN WHOLE OR IN PART ONLY UP TO THE THEN AVAILABLE AMOUNT IN FAVOR OF A NOMINATED TRANSFEREE
(“TRANSFEREE”), ASSUMING SUCH TRANSFER TO SUCH TRANSFEREE IS IN COMPLIANCE WITH ALL APPLICABLE U.S. LAWS AND REGULATIONS. AT THE TIME OF TRANSFER, THE ORIGINAL LETTER OF CREDIT AND ORIGINAL AMENDMENT(S) IF ANY, MUST BE SURRENDERED TO US
TOGETHER WITH OUR TRANSFER FORM (AVAILABLE UPON REQUEST) AND PAYMENT OF OUR CUSTOMARY TRANSFER FEES, WHICH FEES SHALL BE PAYABLE BY APPLICANT (PROVIDED THAT BENEFICIARY MAY, BUT SHALL NOT BE OBLIGATED TO, PAY SUCH FEES TO US ON BEHALF OF APPLICANT,
AND SEEK REIMBURSEMENT THEREOF FROM APPLICANT). IN CASE OF ANY TRANSFER UNDER THIS LETTER OF CREDIT, THE DRAFT AND ANY REQUIRED STATEMENT MUST BE EXECUTED BY THE TRANSFEREE AND WHERE THE BENEFICIARY’S NAME APPEARS WITHIN THIS STANDBY LETTER OF
CREDIT, THE TRANSFEREE’S NAME IS AUTOMATICALLY SUBSTITUTED THEREFOR. 

  
 EXHIBIT C 

-3- 

 ALL DRAFTS REQUIRED UNDER THIS STANDBY LETTER OF CREDIT MUST BE MARKED: ‘‘DRAWN UNDER [Insert Bank
Name] STANDBY LETTER OF CREDIT NO. ___________.” 
 WE HEREBY AGREE WITH YOU THAT IF DRAFTS ARE PRESENTED TO [Insert Bank Name] UNDER THIS LETTER
OF CREDIT AT OR PRIOR TO [Insert Time – (e.g., 11:00 AM)], ON A BUSINESS DAY, AND PROVIDED THAT SUCH DRAFTS PRESENTED CONFORM TO THE TERMS AND CONDITIONS OF THIS LETTER OF CREDIT, PAYMENT SHALL BE INITIATED BY US IN IMMEDIATELY
AVAILABLE FUNDS BY OUR CLOSE OF BUSINESS ON THE SUCCEEDING BUSINESS DAY. IF DRAFTS ARE PRESENTED TO [Insert Bank Name] UNDER THIS LETTER OF CREDIT AFTER [Insert Time – (e.g., 11:00 AM)], ON A BUSINESS DAY, AND PROVIDED THAT SUCH
DRAFTS CONFORM WITH THE TERMS AND CONDITIONS OF THIS LETTER OF CREDIT, PAYMENT SHALL BE INITIATED BY US IN IMMEDIATELY AVAILABLE FUNDS BY OUR CLOSE OF BUSINESS ON THE SECOND SUCCEEDING BUSINESS DAY. AS USED IN THIS LETTER OF CREDIT, “BUSINESS
DAY” SHALL MEAN ANY DAY OTHER THAN A SATURDAY, SUNDAY OR A DAY ON WHICH BANKING INSTITUTIONS IN THE STATE OF CALIFORNIA ARE AUTHORIZED OR REQUIRED BY LAW TO CLOSE. IF THE EXPIRATION DATE FOR THIS LETTER OF CREDIT SHALL EVER FALL ON A DAY WHICH
IS NOT A BUSINESS DAY THEN SUCH EXPIRATION DATE SHALL AUTOMATICALLY BE EXTENDED TO THE DATE WHICH IS THE NEXT BUSINESS DAY. 
 PRESENTATION OF A DRAWING
UNDER THIS LETTER OF CREDIT MAY BE MADE ON OR PRIOR TO THE THEN CURRENT EXPIRATION DATE HEREOF BY HAND DELIVERY, COURIER SERVICE, OVERNIGHT MAIL, OR FACSIMILE. PRESENTATION BY FACSIMILE TRANSMISSION SHALL BE BY TRANSMISSION OF THE ABOVE REQUIRED
SIGHT DRAFT DRAWN ON US TOGETHER WITH THIS LETTER OF CREDIT TO OUR FACSIMILE NUMBER, [Insert Fax Number – (___) ___-____], ATTENTION: [Insert Appropriate Recipient], WITH TELEPHONIC CONFIRMATION OF OUR RECEIPT OF SUCH FACSIMILE
TRANSMISSION AT OUR TELEPHONE NUMBER [Insert Telephone Number – (___) ___-____] OR TO SUCH OTHER FACSIMILE OR TELEPHONE NUMBERS, AS TO WHICH YOU HAVE RECEIVED WRITTEN NOTICE FROM US AS BEING THE APPLICABLE SUCH NUMBER. WE AGREE TO NOTIFY
YOU IN WRITING, BY NATIONALLY RECOGNIZED OVERNIGHT COURIER SERVICE, OF ANY CHANGE IN SUCH DIRECTION. ANY FACSIMILE PRESENTATION PURSUANT TO THIS PARAGRAPH SHALL ALSO STATE THEREON THAT THE ORIGINAL OF SUCH SIGHT DRAFT AND LETTER OF CREDIT ARE BEING
REMITTED, FOR DELIVERY ON THE NEXT BUSINESS DAY, TO [Insert Bank Name] AT THE APPLICABLE ADDRESS FOR PRESENTMENT PURSUANT TO THE PARAGRAPH FOLLOWING THIS ONE. 

WE HEREBY ENGAGE WITH YOU THAT ALL DOCUMENT(S) DRAWN UNDER AND IN COMPLIANCE WITH THE TERMS OF THIS STANDBY LETTER OF CREDIT WILL BE DULY HONORED IF DRAWN AND
PRESENTED FOR PAYMENT AT OUR OFFICE LOCATED AT [Insert Bank Name], [Insert Bank Address], ATTN: [Insert Appropriate Recipient], ON OR BEFORE THE EXPIRATION DATE OF THIS CREDIT, ___(Expiration Date)___. 

  
 EXHIBIT C 

-4- 

 IN THE EVENT THAT THE ORIGINAL OF THIS STANDBY LETTER OF CREDIT IS LOST, STOLEN, MUTILATED, OR OTHERWISE
DESTROYED, WE HEREBY AGREE TO ISSUE A DUPLICATE ORIGINAL HEREOF UPON RECEIPT OF A WRITTEN REQUEST FROM YOU AND A CERTIFICATION BY YOU (PURPORTEDLY SIGNED BY YOUR AUTHORIZED REPRESENTATIVE) OF THE LOSS, THEFT, MUTILATION, OR OTHER DESTRUCTION OF THE
ORIGINAL HEREOF. 
 EXCEPT SO FAR AS OTHERWISE EXPRESSLY STATED HEREIN, THIS STANDBY LETTER OF CREDIT IS SUBJECT TO THE “INTERNATIONAL STANDBY
PRACTICES” (ISP 98) INTERNATIONAL CHAMBER OF COMMERCE (PUBLICATION NO. 590). 
  

			
	Very truly yours,
	
	(Name of Issuing Bank)
		
	By:	 	 

  
 EXHIBIT C 

-5-EX-10.1

 Exhibit 10.1 

Certain identified information identified with brackets (“[***]”) has been excluded from this exhibit because it both (i) is not material and
(ii) would be competitively harmful if publicly disclosed. 
 July 12, 2021 

Mr. Michael D. Wyzga 
 via email: [•••]

 Re: Employment Offer Letter 
 Dear Mike: 

On behalf of Yumanity Therapeutics, I am pleased to offer you employment by Yumanity Therapeutics or its subsidiaries (collectively,
“Yumanity”) on the terms set forth in this letter (the “Offer Letter”). We hope that you choose to join the Yumanity team and look forward to a mutually beneficial relationship. 

1. Position. Upon joining Yumanity, you will assume the role of Senior Vice President and Chief Financial Officer reporting to the CEO.
As you progress with Yumanity, your position and assignments may be subject to change, and we expect you to perform the duties and responsibilities that are associated with your position or otherwise as may be assigned to you. This is a full-time
position. While you render services to Yumanity, we expect you to devote all of your professional and working time and energies to the business of Yumanity and not engage in any other employment, consulting or other business activity (whether
full-time or part-time) without the prior written consent of Yumanity. You agree to abide by all employment polices instituted by Yumanity, as they may be amended from time to time. As stated below, your employment with Yumanity is “at-will,” meaning that your employment may be terminated for any reason, or for no reason, by Yumanity or you at any time. 

2. Commencement Date. Subject to the terms hereof, your employment hereunder will commence on August 16, 2021 (the
“Commencement Date”). 
 3. Compensation. 

(a) Base Salary. In consideration for your services rendered to Yumanity, your base salary will be $350,000 per year, payable in
accordance with Yumanity’s standard payroll schedule and subject to applicable deductions and withholdings. This position is exempt under the Fair Labor Standards Act, meaning that you are not entitled to overtime pay. 

(b) Bonus. During the term of your employment with Yumanity, you will be considered for an annual incentive bonus (the “Annual
Bonus”) with respect to each fiscal year of your employment with Yumanity, the amount, terms and conditions of such Annual Bonus (if any) to be determined at the discretion of the Board of Directors (the “Board”) of
Yumanity or a committee thereof. Your target Annual Bonus will be up to 40% of your base salary. The actual Annual Bonus percentage is discretionary and will be subject to Yumanity’s assessment of your performance, as well as business
conditions at Yumanity. The Annual Bonus also will be subject to your employment for the full period covered by the Annual Bonus, with any Annual Bonus earned in 2021 prorated from the Commencement Date, and approval by and adjustment at the
discretion of the Board or a committee thereof and the terms of any applicable bonus plan. The Annual Bonus, if any, will be paid between January 1st and March 15th of the calendar year following the calendar year for which such Annual Bonus was earned. The payment of any Annual Bonus will be contingent upon you being employed by Yumanity as of the payment date
of such Annual Bonus. Yumanity also may make adjustments in the targeted amount of your Annual Bonus. 

 (c) Stock Option Grant. You will be eligible to participate in the
Company’s equity incentive plan, subject to approval by the Board or Compensation Committee. As a material inducement to becoming an employee of the Company, and subject to approval by the Board or Compensation Committee, the Company will grant
you an option to purchase 65,000 shares of the Company’s common stock (“New Hire Award”). The New Hire Award shall vest over four years, with twenty-five percent of the New Hire Award vesting on
the one-year anniversary of your start date and the remaining shares vesting in thirty-six equal monthly installments following the one-year anniversary of your start date, subject to your continued employment with the Company. The New Hire Award shall be granted in the form of
a non-qualified stock option as an inducement grant consistent with the requirements of Nasdaq Stock Market Rule 5635(c)(4) instead of pursuant to the Company’s existing equity plan. The New
Hire Award will be governed by the terms and conditions of an award agreement. 
 (d) Sign-On
Bonus. Yumanity will pay you a sign-on bonus in the amount of $25,000, minus applicable deductions and withholdings (the “Sign-On Bonus”). The Sign-On Bonus will be paid on the first payroll date following the one year anniversary of the Commencement Date (the “Sign-On Bonus Payment”). You must be
employed by Yumanity on the payment date of such Sign-On Bonus Payment in order to be eligible for such Sign-On Bonus Payment. 

(e) Periodic Review and Adjustments. Notwithstanding the foregoing, all of your compensation terms will be subject to periodic review
and may be modified by Yumanity from time to time in its discretion. 
 4. Reimbursement of Expenses. You will be entitled to prompt
reimbursement for all ordinary and reasonable out-of-pocket business expenses which are, have been or are reasonably incurred by you in furtherance of Yumanity’s
business and in accordance with Yumanity’s standard policies. All reimbursements provided under this Offer Letter will be made or provided in accordance with the requirements of Section 409A
(“Section 409A”) of the Internal Revenue Code of 1986, as amended (the “Code”) including, where applicable, the requirement that (a) any reimbursement is for expenses incurred during your
lifetime (or during a shorter period of time specified in this Offer Letter); (b) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for reimbursement in any other calendar year;
(c) the reimbursement of an eligible expense will be made no later than the last day of the calendar year following the year in which the expense is incurred; and (d) the right to reimbursement or
in-kind benefits is not subject to liquidation or exchange for another benefit. 
 5. Employee
Benefits. As a regular employee of Yumanity, you will be eligible to participate in a number of Yumanity-sponsored benefits provided to other Yumanity employees of similar rank and tenure, subject to the terms and conditions of such policies and
programs. Except when prohibited by applicable law, Yumanity’s benefit plans and fringe benefits may be amended by Yumanity from time to time in its sole discretion, and the provision of such benefits does not change your status as an at-will employee. Your time off is not limited per year but must be scheduled to minimize disruption to Yumanity’s operations, pursuant to the terms and conditions of Yumanity policy and practices as applied to
other Yumanity employees of similar rank and tenure. Paid time off is not accrued, earned, vested, or classified as a wage supplement, and thus, will not be paid out to you upon separation of employment, regardless of the reason for the separation.

  
 2 

 6. Termination; Severance. Notwithstanding the
at-will nature of the parties’ relationship, should Yumanity terminate your employment without “Cause” (described below) or should you resign your employment for “Good Reason”
(described below), then you will be eligible for severance payments and benefits on the terms and conditions described below. 
 (a)
Standard Severance. In the event that Yumanity terminates your employment without Cause or you resign from your employment for Good Reason, in either case in the absence of a “Change of Control” (as defined below), then, conditioned
upon your execution and non-revocation of a separation agreement (the “Separation Agreement”) in a form satisfactory to Yumanity (which will contain, among other things, a full and general release of
claims to Yumanity and its affiliates and their respective directors, officers, agents and employees; standard post-employment obligations; and, as applicable, a non-competition covenant that restricts certain
competitive activities for a specified period of time) and your compliance with your Employee Confidentiality, Non-Competition, Non-Solicitation, and Intellectual
Property Agreement or similar agreements with Yumanity (collectively, “Covenants Agreements”), you will be eligible for the following standard severance package:1/ 
 (i) Yumanity will continue to pay your base salary, at the rate in
effect on the date of termination (or if the termination is for Good Reason due to a reduction in your base salary, at the rate in effect immediately prior to such reduction) for a period of nine (9) months (the “Standard Severance
Period”); and 
 (ii) (x) if Yumanity is subject to the Consolidated Omnibus Budget Reconciliation Act
(“COBRA”) or similar state law, (y) the premium subsidy described below is not illegal or discriminatory under the Code, the Patient Protection and Affordable Care Act or the Health Care and Education Reconciliation Act, and
(z) if you properly elect to receive benefits under COBRA, Yumanity will provide you with nine (9) months of your COBRA premiums at Yumanity’s normal rate of contribution for employees for your coverage at the level in effect
immediately prior to your termination. 
 (b) Change of Control Severance. If within three (3) months prior to or twelve
(12) months after a Change of Control, Yumanity terminates your employment without Cause or you resign from your employment for Good Reason, then, conditioned on your execution and non-revocation of the
Separation Agreement and your compliance with your Covenants Agreement2/, you will be eligible for the following change of control severance
package: 
 (i) Yumanity will continue to pay your base salary, at the rate in effect on the date of termination (or if the
termination is for Good Reason due to a reduction in your base salary, at the rate in effect immediately prior to such reduction) for a period of nine (9) months (the “COC Severance Period”); 

 
  

	1/ 	 In the event of a resignation for any reason (including “Good Reason”) or a termination that
qualifies as “Cause” hereunder (or, as applicable, “Cause” as defined in your Covenants Agreement) then the non-competition covenant will be contained in your Covenants Agreement, with
which you will be expected to comply (the non-competition covenant will not be contained in the separation agreement). Please note that, as stated in your Covenants Agreement, in the event that you are
eligible for garden leave or analogous payments in support of your non-competition obligations under your Covenants Agreement, then Yumanity reserves the right to offset any severance payments or benefits
hereunder against garden leave or analogous payments, to the extent permitted by applicable law. 

	2/ 	 See Note 1. 

  
 3 

 (ii) (x) if Yumanity is subject to the Consolidated Omnibus Budget
Reconciliation Act (“COBRA”) or similar state law, (y) the premium subsidy described below is not illegal or discriminatory under the Code, the Patient Protection and Affordable Care Act or the Health Care and Education Reconciliation
Act, and (z) if you properly elect to receive benefits under COBRA, Yumanity will provide you with your COBRA premiums at Yumanity’s normal rate of contribution for employees for your coverage at the level in effect immediately prior to
your termination, through the COC Severance Period; 
 (iii) All of your granted equity that remains unvested as of the
termination date automatically will vest as of the date the Separation Agreement is signed and irrevocable, subject to the terms and conditions of the applicable Company equity plan and equity agreements signed by you pursuant thereto; and 

(iv) The deadline for you to exercise any vested stock options will be extended to the COC Severance Period or, if earlier, the
normal expiration date of such options, subject to the terms and conditions of the applicable Company equity plan and equity agreements signed by you pursuant thereto. 

Please note that in the event that you are eligible for the severance payments and benefits described in this Section 6(b), then you will
not be eligible for the severance payments and benefits described in Section 6(a). 
 (c) Definitions. 

(i) For purposes of this Offer Letter, “Cause” will mean any one or more of the following actions: (A) your
material breach of the terms of your Offer Letter or the terms of your Covenants Agreements; (B) your material dishonesty, willful misconduct, gross negligence, or reckless conduct in each case, if such conduct is in connection with the
performance of your services to Yumanity; (C) your commission of an act of fraud, theft, misappropriation or embezzlement; (D) your indictment of, or pleading nolo contendere to, any crime involving moral turpitude or any felony; or
(E) your material violation of a Company policy that had been previously provided to you in writing, or your willful refusal to perform your lawful assigned duties to Yumanity (other than as a result of your mental or physical impairment). For
purpose solely of this clause (E), “Cause” will only exist if: (1) Yumanity delivered to you a written description of the events or conditions giving rise to your termination for Cause; and (2) if curable, you have been given at
least 30 days to cure such events or conditions and you fail to cure such events or conditions within such time period given. 

(ii) For purposes of this Offer Letter, “Good Reason” will mean a Separation as a result of your resignation after
one of the following conditions has come into existence without your consent: (A) a material reduction in your base salary; (B) a material diminution of your authority, duties, or responsibilities; (C) a material breach by Yumanity of
this Offer Letter, or any equity agreement signed by you; or (D) a relocation of your principal workplace by more than 50 miles. A resignation for Good Reason pursuant to any of the clauses described above will not be deemed to have occurred
unless: (1) you give Yumanity written notice of the condition constituting Good Reason within 30 days after the initial existence of the condition, (2) if curable, the condition is not cured by Yumanity within 30 days of its receipt of
such notice, and (3) your termination of employment occurs within 65 days following Yumanity’s receipt of your notice described in (1). 

  
 4 

 (iii) For purposes of this Letter, “Change of Control” will mean:
(A) any “Person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “Beneficial Owner” (as defined in Rule 13d-3 under the Exchange Act), directly or
indirectly, of securities of Yumanity representing 50% or more of the total voting power represented by Yumanity’s then outstanding voting securities (excluding for this purpose any such voting securities held by Yumanity or its Affiliates or
by any employee benefit plan of Yumanity) pursuant to a transaction or a series of related transactions which the Board does not approve; or (B) a merger or consolidation of Yumanity whether or not approved by the Board, other than a merger or
consolidation which would result in the voting securities of Yumanity outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent
of such corporation) more than 50% of the total voting power represented by the voting securities of Yumanity or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or
(C) the sale or disposition by Yumanity of all or substantially all of Yumanity’s assets in a transaction requiring stockholder approval. “Change of Control” will be interpreted, if applicable, in a manner, and limited to the
extent necessary, so that it will not cause adverse tax consequences under Section 409A of the Code. 
 (iv) For
purposes of this Offer Letter, “Separation” means a “separation from service,” as defined in the regulations under Section 409A of the Code. 

(d) Payment Timing. Provided that you meet the conditions for severance payments and benefits described in Sections 6(a) or 6(b), as
applicable, any severance payments paid according to terms herein will commence or be made within 60 days after the date of termination, provided that: (i) if the 60-day period begins in one calendar year
and ends in a second calendar year, the severance payments will begin to be paid in the second calendar year by the last day of such 60-day period; and (ii) the initial payment will include a catch-up payment to cover amounts retroactive to the day immediately following the date of termination. 

(e) Exclusions. Should you voluntarily terminate your employment without Good Reason or should your employment be terminated for Cause
(whether before or after a Change of Control), then you will not be eligible for any severance payments or benefits described herein. In the event that you are eligible for severance payments or benefits under any other employment, severance or
separation agreement or policy, or any provisions thereof, this Offer Letter replaces and supersedes such agreement or policy (or any provisions thereof) and you will not receive any payments or benefits under such agreement or policy (or any
provisions thereof). 

  
 5 

 7. Forfeiture/Clawback. Please note that the compensation described in this Offer
Letter will be subject to any forfeiture or clawback policy established by Yumanity generally for executives from time to time. 
 8.
Confidentiality, Non-Competition, Non-Solicitation, and Intellectual Property Agreement. As part of your employment with Yumanity, you have and will be exposed
to, and provided with, valuable confidential and/or trade secret information concerning Yumanity and its present and prospective clients. Like all Yumanity employees, you will be required, as a condition of your employment with Yumanity, to sign
Yumanity’s standard Employee Confidentiality, Non-Competition, Non-Solicitation, and Intellectual Property Agreement, a copy of which is attached hereto as
Exhibit A and the terms of which are incorporated into this Offer Letter. 
 9. Representation Regarding Other
Obligations. This offer is conditioned on your representation that you are not subject to any confidentiality, non-competition agreement or any other similar type of restriction that may affect your
ability to devote full time and attention to your work at Yumanity. If you have entered into any agreement that may restrict your activities on behalf of Yumanity, please provide me with a copy of the agreement as soon as possible. Please understand
that Yumanity does not want you to disclose any confidential information belonging to a previous employer or to incorporate the proprietary information of any previous employer into Yumanity’s proprietary information and expects that you will
abide by restrictive covenants to prior employers. 
 10. Return of Property and Records. Upon the termination of your employment
hereunder for any reason, you will: (a) return to Yumanity all Yumanity confidential information and copies thereof (regardless of how such confidential information or copies are maintained) in your possession; and (b) deliver to Yumanity
any property of Yumanity which may be in your possession, including, but not limited to, cell phones, smart phones, laptops, products, materials, memoranda, notes, records, reports or other documents or photocopies of the same. 

11. Work Authorization; Background Check. Notwithstanding anything to the contrary herein, your employment with Yumanity is conditioned
on: (a) satisfactory completion of reference and background checks; and (b) your submission of satisfactory proof of your legal authorization to work in the United States. Coincident with starting your employment with Yumanity, you will be
expected to sign an I-9 form verifying that you are legally authorized to work in the United States. Attached as Exhibit B is a copy of the I-9 form. Please bring
the appropriate document(s) listed on that form with you when you report for work. Yumanity will not be able to employ you if you fail to comply with these requirements. 

12. Employment Relationship. Subject to Section 6, your employment with Yumanity will be “at will,” meaning that either
you or Yumanity may terminate your employment at any time and for any reason, with or without cause. Any contrary representations that may have been made to you are superseded by this Offer Letter. This is the full and complete agreement between you
and Yumanity on this term. Although your job duties, title, compensation and benefits, as well as Yumanity’s personnel policies and procedures, may change from time to time, the “at will” nature of your employment may only be changed
in an express written agreement signed by you and a duly authorized officer of Yumanity (other than you). 
 13. Tax Matters. 

(a) All forms of compensation referred to in this Offer Letter are subject to reduction to reflect applicable withholding and payroll taxes and
other deductions required by law. You are encouraged to obtain your own tax advice regarding your compensation from Yumanity. Yumanity does not guarantee the tax treatment or tax consequences associated with any payment or benefit arising under this
Offer Letter, including but not limited to consequences related to Section 409A of the Code. You agree that Yumanity does not have a duty to design its compensation policies in a manner that minimizes your tax liabilities, and you will not make
any claim against Yumanity or its Board related to tax liabilities arising from your compensation. 

  
 6 

 (b) This Offer Letter will be interpreted and at all times administered in a manner that
avoids the inclusion of compensation in income under Section 409A of the Code. Any provision inconsistent with Section 409A of the Code will be read out of the Offer Letter. For purposes of clarification, this paragraph will be a rule of
construction and interpretation and nothing in this paragraph will cause a forfeiture of benefits on the part of you. It is intended that each installment of the payments and benefits provided under this Offer Letter will be treated as a separate
“payment” for purposes of Section 409A of the Code. Neither Yumanity nor you will have the right to accelerate or defer the delivery of any such payments or benefits, except to the extent specifically permitted or required by
Section 409A of the Code. 
 (c) Notwithstanding any other provision of this Offer Letter to the contrary, if any amount (including
imputed income) to be paid to you pursuant to this Offer Letter as a result of your termination of employment is “deferred compensation” subject to Section 409A of the Code, and if you are a “Specified Employee” under
Section 409A of the Code as of the date of your termination of employment, then, to the extent necessary to avoid the imposition of excise taxes or other penalties under Section 409A of the Code, the payment of benefits, if any, scheduled
to be paid by Yumanity to you hereunder during the first 6-month period following the date of a termination of employment hereunder will not be paid until the date which is the first business day after 6
months have elapsed since your termination of employment. Any deferred compensation payments delayed in accordance with the terms of this paragraph will be paid in a lump sum after 6-months have elapsed since
your termination of employment. Any other payments will be made according to the schedule provided for herein. 
 (d) If any of the benefits
set forth in this Offer Letter are “deferred compensation” under Section 409A of the Code, any termination of employment triggering payment of such benefits must constitute a “separation from service” under Section 409A
of the Code before distribution of such benefits can commence. To the extent that the termination of your employment does not constitute a “separation from service” under Section 409A of the Code (as the result of further services
that are reasonably anticipated to be provided by you to Yumanity at the time your employment terminates), any benefits payable under this Offer Letter that constitute “deferred compensation” under Section 409A of the Code will be
delayed until after the date of a subsequent event constituting a “separation from service” under Section 409A of the Code. For purposes of clarification, this paragraph will not cause any forfeiture of benefits on your part, but will
only act as a delay until such time as a “separation from service” occurs. 
 (e) If any payment or benefit you would receive under
this Offer Letter, when combined with any other payment or benefit you receive pursuant to a Change of Control (for purposes of this paragraph, a “Payment”) would: (i) constitute a “parachute payment” within the meaning of
Section 280G the Code; and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment will be either: (1) the full amount of such Payment;
or (2) such lesser amount as would result in no portion of the Payment being subject to the Excise Tax, whichever of the foregoing amounts, taking into account the applicable federal, state and local employments taxes, income taxes and the
Excise Tax, results in your receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. With respect to
subsection (2), if there is more than one method of reducing the payment as would result in no portion of the Payment being subject to the Excise Tax, then you will determine which method will be followed, provided that if you fail to make such
determination within 30 days after Yumanity has sent you written notice of the need for such reduction, Yumanity may determine the amount of such reduction in its sole discretion. 

  
 7 

 14. Interpretation, Amendment and Assignment. This Offer Letter, together with any
agreements specifically referred to herein, constitute the complete agreement between you and Yumanity, contain all of the terms of your employment with Yumanity and supersede any prior agreements, representations or understandings (whether written,
oral or implied) between you and Yumanity. This Offer Letter may not be amended or modified, except by an express written agreement signed by both you and a duly authorized officer of Yumanity (other than you). Yumanity may assign its rights and
obligations hereunder to any person or entity that succeeds to all or substantially all of Yumanity’s business. You may not assign your rights and obligations hereunder without the prior written consent of Yumanity. 

15. Choice of Law and Forum Selection. The terms of this Offer Letter and the resolution of any disputes as to the meaning, effect,
performance or validity of this Offer Letter or arising out of, related to, or in any way connected with, this Offer Letter, your employment with Yumanity or any other relationship between you and Yumanity (the “Disputes”) will be
governed by Massachusetts law, excluding laws relating to conflicts or choice of law. You and Yumanity submit to the exclusive personal jurisdiction of the federal and state courts located in Boston, Massachusetts, in connection with any Dispute or
any claim related to any Dispute. You and Yumanity waive and forever renounce your right to a trial before a civil jury. 
 We hope that you
will accept our offer to join Yumanity. You may indicate your agreement with these terms and accept this offer by signing and dating both the enclosed duplicate original of this Offer Letter and the enclosed Employee Confidentiality, Non-Competition, Non-Solicitation and Intellectual Property Agreement, and returning them to me. 

[Signature Page Follows] 

  
 8 

 
			
	Very truly yours,
	
	YUMANITY THERAPEUTICS
		
	By:	 	 /s/ Ellen K. Forest

	Name: Ellen K. Forest
	Title: Chief Human Resources Officer

 I have read and accept this employment offer: 
  

	
	 /s/ Michael D. Wyzga

	Signature of Employee
	
	Dated: July 12, 2021

 Attachments 
  

			
	Exhibit A:	  	Employee Confidentiality, Non-Competition, Non-Solicitation and Intellectual Property Agreement
		
	Exhibit B:	  	Form I-9

  
 9 

 Exhibit A 

July 11, 2021 
 Mr. Michael D. Wyzga 

via email: [•••] 
 Re:
Confidentiality, Non-Competition, Non-Solicitation and Intellectual Property Agreement 

Dear Mike:
 This letter agreement (the
“Agreement”) is to confirm our understanding with respect to: (a) your agreement to protect and preserve confidential and proprietary information of Yumanity Therapeutics or any present or future parent, subsidiary or affiliate
thereof (collectively, the “Company”); (b) your agreement not to compete with the Company; (c) your agreement not to solicit or otherwise interfere with any of the Company’s customers or employees; and (d) your
agreement with respect to the ownership of inventions, ideas, copyrights and patents which may be used in the business of the Company. As a condition of your employment with the Company, and in consideration of the mutual promises and covenants
contained in this Agreement and other good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, you agree as follows: 

1. Confidentiality. 
 (a)
Definition of Confidential Information. For purposes of this Agreement, “Confidential Information” means trade secrets and confidential and proprietary information of the Company, or any information provided to you or the
Company under an obligation of confidentiality to a third party, or any confidential, trade secret, or proprietary information acquired by the Company from others with whom the Company or any affiliate has a business relationship, whether in
written, oral, electronic or other form, including, but not limited to, technical data and specifications, business and financial information, product and marketing plans, customer and client information, customer and client lists, customer, client
and vendor identities and characteristics, agreements, marketing knowledge and information, sales figures, pricing information, marketing plans, business plans, strategy forecasts, financial information, budgets, software, projections and
procedures, the confidential evaluation of (and confidential use or non-use by the Company or any affiliate of) technical or business information in the public domain, Developments (as defined in
Section 3), and any other scientific, technical or trade secrets of the Company or of any third party provided to you or the Company under a condition of confidentiality, provided that Confidential Information shall not include
information that is in the public domain other than through any fault or act by you.3/ 

 
  

	3/ 	 The term “trade secrets,” as used in this Agreement, shall be given its broadest possible
interpretation under the law of the Commonwealth of Massachusetts and shall include, without limitation, any specified or specifiable information, whether or not fixed in tangible form or embodied in any tangible thing, including but not limited to
a formula, pattern, compilation, program, device, method, technique, process, business strategy, customer list, invention, or scientific, technical, financial or customer data. 

  
 10 

 (b) Protection and Non-Disclosure of Confidential
Information. You expressly acknowledge and agree that all Confidential Information is and shall remain the sole property of the Company or the third party to whom the Company owes an obligation of confidentiality and that you shall hold
it in strictest confidence. You shall at all times, both during the period you are performing services for the Company and after the termination of such services for any reason or for no reason, maintain in confidence and shall not, without the
prior written consent of the Company, use (except in the course of performance of your duties for the Company or by court order), disclose, or give to others any Confidential Information. 

(c) Notification to Company. In the event you are questioned by anyone not employed by the Company or by an employee of or a consultant
to the Company not authorized to receive Confidential Information, in regard to any Confidential Information or concerning any fact or circumstance relating thereto, you shall promptly notify the Company. 

(d) Return of Confidential Information. Upon the termination of your services to the Company for any reason or for no reason, or if the
Company otherwise requests, you will: (i) return to the Company all tangible Confidential Information and copies thereof (regardless how such Confidential Information or copies are maintained), and (ii) deliver to the Company any property
of the Company which may be in your possession, including, but not limited to, products, materials, memoranda, notes, records, reports, or other documents or photocopies of the same. 

(e) No Impact on Other Obligations. The terms of this Section 1 are in addition to, and not in lieu of, any statutory or other
contractual or legal obligation that you may have relating to the protection of the Company’s Confidential Information. The terms of this Section 1 shall survive indefinitely any termination of your provision of services to the Company for
any reason or for no reason. 
 (f) Notice Pursuant to Defend Trade Secrets Act. Notwithstanding any provision of this Agreement
prohibiting the disclosure of Developments (as defined in Section 2) or other Confidential Information, you understand that you may not be held criminally or civilly liable under any federal or state trade secret law for the disclosure of a
Company trade secret that: (i) is made (A) in confidence to a federal, state or local government official, either directly or indirectly, or to an attorney; and (B) solely for the purpose of reporting or investigating a suspected
violation of law; or (ii) is made in a complaint or other document filed in a lawsuit or other proceeding, if such filing is made under seal. In addition, if you file a lawsuit or other court proceeding against the Company for retaliating
against you for reporting a suspected violation of law, you may disclose the Company trade secret to the attorney representing you and use the Company trade secret in the court proceeding, if you file any document containing the Company trade secret
under seal and do not disclose the trade secret, except pursuant to court order.
 2. Prohibited Competition and Solicitation. 

(a) Acknowledgements and Agreements Regarding Competition. You expressly acknowledge that: (i) there are competitive and
proprietary aspects of the business of the Company; (ii) during the course of your performing services for the Company, the Company shall furnish, disclose or make available to you Confidential Information (as defined in Section 1) and may
provide you with unique and specialized training; (iii) such Confidential Information and training have been developed and shall be developed by the Company through the expenditure of substantial time, effort and money, and could be used by you
to compete with the Company; (iv) if you become employed or affiliated with any competitor of the Company in violation of your obligations in this Agreement, it is inevitable that you would disclose the Confidential Information to such
competitor and would use such Confidential Information, knowingly or unknowingly, on behalf of such competitor; (v) in the course of your employment, you shall be introduced to vendors, suppliers, customers, consultants, contractors, employees
and others with important relationships to the Company, and any and all “goodwill” created through such introductions belongs exclusively to the Company, including, but not limited to, any goodwill created as a result of direct or indirect
contacts or relationships between you and any vendors, suppliers or customers of the Company. 

  
 11 

 (b) Definitions. 

(i) “Competing.” For the purposes of this Agreement, a business shall be deemed to be “Competing” with the Company
if the business performs or is planning to perform any of the same or similar services, manufacturing, research, or development provided by the Company during the last two years of your employment by the Company; or is a business in which you could
reasonably be expected to use or disclose Confidential Information. 
 (ii) “Non-Competition
Period.” For the purposes of this Agreement, the term “Non-Competition Period” is defined as the one (1) year period following the termination of your employment with the Company for
Cause (as that term is defined under your employment agreement, or, if not defined in an employment agreement, as that term is defined under Massachusetts law) or your resignation of your employment with the Company for any reason. 

(iii) “Non-Solicitation Period.” For the purposes of this Agreement, the term “Non-Solicitation Period” is defined as the two (2) year period following the termination of your employment with the Company for any reason or for no reason, whether voluntary or involuntary. 

(iv) “Restricted Territory.” For the purposes of this Agreement, the term “Restricted Territory” is defined as any
regional area or territory in which you performed services on behalf of the Company or had a material presence or influence in the two years immediately preceding the termination of your employment with the Company, or in which the Company engaged
in any business activity or was actively planning to engage in any business activity at any time during your employment with the Company. 

(c) Non-Competition Restriction. During the period in which you are employed by the Company and
for the Non-Competition Period, you shall not engage in the following activities either through or on behalf of yourself, a third party or another person/entity, whether directly or indirectly, either as
principal, partner, stockholder, officer, director, member, employee, consultant, agent, representative or in any other capacity, own, manage, operate or control, or be concerned, connected or employed by, or otherwise associate in any manner with,
engage in, or have a financial interest in, any business which is directly or indirectly Competing with the business of the Company within the Restricted Territory (each, a “Restricted Activity”). For the avoidance of doubt, this
Section 2(c) shall not apply to you in the event your employment is terminated without Cause or if the Company elects to waive this Section 2(c) in accordance with Section 2(c)(ii) below. 

  
 12 

 (i) Garden Leave. In consideration of your agreement not to compete during the Non-Competition Period as set forth above in Section 2(c), and so long as you comply with the obligations under Section 2(c), the Company shall pay you an amount equal to fifty percent (50%) of your
highest annualized base salary in the two years immediately preceding the commencement of the Non-Competition Period, to be paid in accordance with the Company’s normal payroll practices. For the
purposes of this subsection 2(c)(i), “highest annualized base salary” shall mean the highest averaged amount of compensation paid to you for any twelve month period during the two year period immediately preceding commencement of the Non-Competition Period, but shall not include any other form of compensation, including but not limited to, commissions, bonuses, reimbursement of expenses, travel discounts or other fringe benefits. The
Company reserves the right to apply any severance payments made to you by the Company, or a portion thereof, against the installment payments under this Section 2(c)(i). 

(ii) Waiver of Non-Competition Period. The Company, in its sole discretion, may elect at any
time prior to the commencement of the Non-Competition Period, or on such later date to the extent permitted by applicable law, to waive the restrictions set forth in Section 2(c), which such waiver shall
automatically terminate Company’s obligations to compensate you under Section 2(c)(i) above. In such event, you shall have no further obligation under Section 2(c) above. Such waiver shall be provided in writing by the Company
pursuant to Section 7(j) below. Such waiver shall have no effect on your obligations under the remainder of this Agreement, which shall continue in full force and effect in all respects. You acknowledge and agree that nothing in this
Section 2(c)(ii) gives you an election as to compliance with Section 2(c). 
 (iii) Remedies Upon Breach. You acknowledge
and agree that if you breach any of your obligations under Section 2(c) of this Agreement at any time during the Non-Competition Period, then, in addition to any other remedies that the Company may have
against you, including but not limited to injunctive relief, the Company shall immediately cease any and all payments to you pursuant to Section 2(c)(i) and you shall be obligated to immediately return any and all payments previously made by
the Company pursuant to Section 2(c)(i). 
 (iv) Notice of Subsequent Employment or Engagement. You agree that at any point prior
to the commencement of the Non-Competition Period, in the event that you are considering an opportunity that would require you to engage in a Restricted Activity (including, but not limited to, an offer of
employment), you shall notify the Chief Human Resources Officer at the Company in writing of such opportunity. You acknowledge and agree that your acceptance of the payments under Section 2(c)(i) shall be an express representation to the
Company that you are in compliance with this Section 2(c)(iv). 
 (v) Material Breach. You acknowledge and agree that a breach of
any provision of this Section 2(c) is a material breach of this Agreement. 

  
 13 

 (d) Non-Solicitation Restriction. 

(i) Customers. During the period in which you are employed by the Company and for the
Non-Solicitation Period, you shall not engage in the following activities either through or on behalf of yourself, a third party or another person/entity, whether directly or indirectly: (A) solicit,
divert or appropriate, or attempt to solicit, divert or appropriate, any so called “corporate partner” or “collaborator” or any customer, client, vendor, supplier, or patron of the Company, or any prospective so called
“corporate partner” or “collaborator” or any prospective customer, client, vendor, supplier, or patron to which the Company has developed or made a collaboration, joint venture or sales presentation (or similar offering of
services); or (B) interfere with, or attempt to interfere with, the relations between the Company and any customer, client, vendor, supplier, patron, or so-called “corporate partner” or
“collaborator” to the Company. 
 (ii) Employees. During the period in which you are employed by the Company and for the Non-Solicitation Period, you shall not engage in the following activities either through or on behalf of yourself, a third party or another person/entity, whether directly or indirectly: (A) solicit, entice or
persuade, or attempt to solicit, entice or persuade, any other employees of or consultants to the Company to leave the services of the Company or any such parent, subsidiary or affiliate for any reason; or (B) employ, cause to be employed, or
solicit the employment or services of any employee of or consultant to the Company while any such person is providing services to the Company or within one (1) year after any such person ceases providing services to the Company. 

(e) Tolling. You acknowledge and agree that the Non-Solicitation Period shall be tolled and
shall not run, during any period in which you are in violation of the terms herein. 
 3. Developments. 

(a) Prior Developments. You have attached hereto, as Exhibit A, a list describing all discoveries, ideas, inventions,
improvements, enhancements, processes, methods, techniques, developments, software, and works of authorship, whether patentable or not, which were created, made, conceived or reduced to practice by you prior to your employment with the Company and
which are owned by you, which relate directly or indirectly to the current or anticipated future business of the Company, and which are not assigned to the Company hereunder (collectively, “Prior Developments”); or, if no such list
is attached, you represent that there are no Prior Developments. You agree that you have not and shall not incorporate any Prior Developments into any Company product, material, process or service without prior written consent of an officer of the
Company. If you do incorporate any Prior Development into any Company product, material, process or service, you hereby grant to the Company a non-exclusive, worldwide, perpetual, transferable, irrevocable,
royalty-free, fully-paid right and license to make, have made, use, offer for sale, sell, import, reproduce, modify, prepare derivative works, display, perform, transmit, distribute and otherwise exploit such Prior Development and to practice any
method related thereto. 
 (b) Developments. All ideas, discoveries, creations, manuscripts and properties, innovations, improvements,
know-how, inventions, designs, developments, apparatus, techniques, methods, formulae, data, protocols, writings, specifications, sound recordings, and pictorial and graphical representations, (collectively,
“Developments”) which relate to the business of the Company or a Company affiliate, whether patentable, copyrightable or not, which you may conceive, reduce to practice or develop during your employment with the Company, whether
alone or in conjunction with another or others, and whether at the request or upon the suggestion of the Company or otherwise, shall be and are the sole and exclusive property of the Company. You acknowledge that each original work of authorship
which was made by you (solely or jointly with others) within the scope of and during the period of your employment with the Company and which is protectable by copyright is a “work made for hire,” as that term is defined in the United
States Copyright Act. You agree to assign and do hereby assign to the Company (or any person or entity designated by the Company) all your right, title and interest in and to all Developments (other than Prior Developments listed on Exhibit
A, if any) and all related patents, patent applications, copyrights and copyright applications. However, this Section 3(b) shall not apply to Developments which do not relate to the business or research and development conducted or planned
to be conducted by the Company at the time such Development is created, made, conceived or reduced to practice and which were made and conceived by you outside of the scope of employment and not using the Company’s tools, devices, equipment or
Confidential Information. You also hereby waive all claims to moral rights in any Developments. 

  
 14 

 (c) Cooperation. You agree to cooperate fully with the Company, both during and after
your employment with the Company, with respect to the procurement, maintenance and enforcement of copyrights, patents and other intellectual property rights (both in the United States and foreign countries) relating to Developments. You shall sign
all papers, including, without limitation, copyright applications, patent applications, declarations, oaths, formal assignments, assignments of priority rights, and powers of attorney, which the Company may deem necessary or desirable in order to
protect its rights and interests in any Development. You further agree that if the Company is unable, after reasonable effort, to secure you signature on any such papers, any executive officer of the Company shall be entitled to execute any such
papers as your agent and your attorney-in-fact, and you hereby irrevocably designate and appoint each executive officer of the Company as your agent and attorney-in-fact to execute any such papers on your behalf, and to take any and all actions as the Company may deem necessary or desirable in order to protect its rights and
interests in any Development, under the conditions described in this sentence. 
 4. Disclosure to Future Employers. 

You shall provide, and the Company, in its discretion, may similarly provide, a copy of this Agreement or specific covenants herein to any
business or enterprise which you may directly or indirectly own, manage, operate, finance, join, control or in which you may participate in the ownership, management, operation, financing, or control, or with which you may be connected as an
officer, director, employee, partner, principal, agent, representative, consultant or otherwise. 
 5. Your Representations and Warranties.

 You hereby represent and warrant that: (a) you have no commitments, agreements or legal obligations that are inconsistent with
this Agreement or that restrict your ability to be employed by or perform other services for the Company; and (b) the Company has advised you that at no time should you divulge to or use for the benefit of the Company any trade secret or
confidential or proprietary information of any previous employer or other third party, and that you have not divulged or used and shall not divulge or use any such information for the benefit of the Company. You expressly acknowledge and
agree that you shall indemnify and hold the Company harmless against loss, damage, liability or expense arising from any claim based upon circumstances alleged to be inconsistent with the representations and warranties above. 

6. Provisions Necessary and Reasonable; Injunctive Relief. 

(a) Reasonableness of Restrictions. You acknowledge and agree that the provisions of Sections 1, 2 and 3 of this Agreement are necessary
and reasonable to protect the Company’s Confidential Information, property rights, trade secrets, goodwill and business interests. You further acknowledge and agree that the types of employment which are prohibited by Section 2 are narrow
and reasonable in relation to the skills which represent your principal salable asset both to the Company and to your other prospective employers, and that the specific but broad temporal and geographical scope of Section 2 is reasonable and
fair in light of the Company’s need to market its services and develop and sell its products in a large geographic area in order to maintain a sufficient customer base and in light of your material presence or influence in the Restricted
Territory during the last two years of your employment with the Company. 

  
 15 

 (b) Injunctive Relief. You hereby expressly acknowledge that any breach or threatened
breach of any of the terms of Sections 1, 2 or 3 of this Agreement shall result in substantial, continuing and irreparable injury to the Company. Therefore, in addition to any other remedy available to the Company, the Company shall be entitled to
injunctive or other equitable relief by a court of appropriate jurisdiction in the event of any breach or threatened breach of the terms of Sections 1, 2 or 3 of this Agreement, without posting any bond or security, and without affecting the
Company’s right to seek and obtain damages or other equitable relief. 
 8. General. 

(a) Notices. All notices, requests, consents and other communications hereunder shall be in writing, shall be addressed to the receiving
party’s address set forth above or to such other address as a party may designate by notice hereunder, and shall be either (i) delivered by hand, (ii) sent by overnight courier, (iii) sent by registered mail, return receipt
requested, postage prepaid, or (iv) sent by email. All notices, requests, consents and other communications hereunder shall be deemed to have been given either (A) if by hand, at the time of the delivery thereof to the receiving party at
the address of such party set forth above, (B) if by overnight courier, on the next business day following the day such notice is delivered to the courier service, (C) if by registered mail, on the fifth business day following the day such
mailing is made, or (D) if by email, upon confirmation of receipt from the receiving party. 
 (b) Entire Agreement. This
Agreement embodies the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No
statement, representation, warranty, covenant or agreement of any kind not expressly set forth in this Agreement shall affect, or be used to interpret, change or restrict, the express terms and provisions of this Agreement. 

  
 16 

 (c) Modifications and Amendments. The terms and provisions of this Agreement may be
modified or amended only by written agreement executed by the parties hereto. 
 (d) Assignment. The Company may assign its rights and
obligations hereunder to any person or entity that succeeds to all or substantially all of the Company’s business or that aspect of the Company’s business in which you are principally involved. You may not assign your rights and
obligations under this Agreement without the prior written consent of the Company and any such attempted assignment by you without the prior written consent of the Company shall be void. You acknowledge and agree that if you should transfer between
or among any affiliates of the Company, wherever situated, or be promoted or reassigned to functions other than your present functions, all terms of this Agreement shall continue to apply with full force. 

(e) Benefit. All statements, representations, warranties, covenants and agreements in this Agreement shall be binding on the parties
hereto and shall inure to the benefit of the respective successors and permitted assigns of each party hereto. Nothing in this Agreement shall be construed to create any rights or obligations except between the Company and you, and no person or
entity other than the Company shall be regarded as a third-party beneficiary of this Agreement. 

(f) Governing Law; Jurisdiction; Venue; Waiver of Jury Trial. This Agreement and the rights and obligations of the parties hereunder
shall be construed in accordance with and governed by the law of the Commonwealth of Massachusetts, without giving effect to conflict of law principles thereof, and specifically excluding any conflict or choice of law rule or principle that might
otherwise refer construction or interpretation of this Agreement to the substantive law of another jurisdiction. Any legal action or proceeding with respect to this Agreement shall be brought in Suffolk County Superior Court, Business Litigation
Session, Boston, Massachusetts. By execution and delivery of this Agreement, each of the parties hereto accepts for itself and in respect of its property, generally and unconditionally, the exclusive jurisdiction of the aforesaid courts. ANY
ACTION, DEMAND, CLAIM OR COUNTERCLAIM ARISING UNDER OR RELATING TO THIS AGREEMENT SHALL BE RESOLVED BY A JUDGE ALONE AND EACH OF THE COMPANY AND YOU WAIVE ANY RIGHT TO A JURY TRIAL THEREOF. 

(g) Severability and Blue Pencil. The parties intend this Agreement to be enforced as written. However, (i) if any portion or
provision of this Agreement is to any extent declared illegal or unenforceable by a duly authorized court having jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as
to which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law; and (ii) if any provision, or part
thereof, is held to be unenforceable because of the duration of such provision or the geographic area covered thereby, the court making such determination shall have the power to reduce the duration and/or geographic area of such provision, and/or
to delete specific words and phrases (“blue-penciling”), and in its reduced or blue-penciled form such provision shall then be enforceable and shall be enforced. 

(h) Survival of Acknowledgements and Agreements. Your acknowledgements and agreements set forth in Sections 1, 2 and 3 shall survive the
termination of your provision of services to the Company for any reason or for no reason, pursuant to the terms and conditions herein. 

  
 17 

 (i) Headings and Captions. The headings and captions of the various subdivisions of
this Agreement are for convenience of reference only and shall in no way modify or affect the meaning or construction of any of the terms or provisions hereof. 

(j) No Waiver of Rights, Powers and Remedies. The terms and provisions of this Agreement may be waived, or consent for the departure
therefrom granted, only by a written document executed by the party entitled to the benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or
provisions of this Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose for which it was given, and shall not constitute a continuing waiver or consent. No failure or
delay by a party hereto in exercising any right, power or remedy under this Agreement, and no course of dealing between the parties hereto, shall operate as a waiver of any such right, power or remedy of the party. No single or partial exercise of
any right, power or remedy under this Agreement by a party hereto, nor any abandonment or discontinuance of steps to enforce any such right, power or remedy, shall preclude such party from any other or further exercise thereof or the exercise of any
other right, power or remedy hereunder. The election of any remedy by a party hereto shall not constitute a waiver of the right of such party to pursue other available remedies. 

(k) Expenses. Should any party breach this Agreement, in addition to all other remedies available at law or in equity, such party shall
pay all of the other party’s costs and expenses resulting therefrom and/or incurred in enforcing this Agreement, including legal fees and expenses. 

(l) Counterparts. This Agreement may be executed in two or more counterparts, and by different parties hereto on separate counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 (m) Acknowledgment;
Opportunity to Review. You hereby acknowledge that you have had at minimum ten (10) business days to review the terms and conditions set forth in this Agreement, including the obligations and agreements under Section 2(c), and that you
have had the opportunity to consult with counsel of your own choosing regarding such terms. You further acknowledge that you fully understand the terms of this Agreement and have voluntarily executed this Agreement. 

If the foregoing accurately sets forth our agreement, please so indicate by signing and returning to us the enclosed copy of this Agreement.

 [SIGNATURE PAGE FOLLOWS] 

  
 18 

 Certain identified information identified with brackets (“[•••]”) has been excluded
from this exhibit because it both (i) is not material and (ii) would be competitively harmful if publicly disclosed. 
 EXHIBIT 10.1 Employment
Offer Letter by and between Yumanity Therapeutics, Inc. and Michael D. Wyzga, dated July 12, 2021. (redacted) 
 Execution
Copy 
 IN WITNESS WHEREOF the Parties have signed this Confidentiality,
Non-Competition, Non-Solicitation and Intellectual Property Agreement as of the date signed below. 

 

			
	COMPANY:
	
	YUMANITY THERAPEUTICS
		
	By:	 	 /s/ Ellen K. Forest

		 	Name: Ellen K. Forest
		 	Title: Chief Human Resources Officer
	
	Acknowledge and Agreed:
	
	 /s/ Michael D. Wyzga

	Name: Michael D. Wyzga
	
	Date: July 12, 2021
	
	Address: [•••]

 EXHIBIT A 

LIST OF PRIOR DEVELOPMENTS AND ORIGINAL
WORKS OF AUTHORSHIP 
  

					
	 Title
	  	 Date
	  	 Identifying Number or Brief Description

  
 20

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