Document:

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                 MORGAN STANLEY DEAN WITTER SELECT EQUITY TRUST
                   STRATEGIC GROWTH LARGE-CAP PORTFOLIO 2000-2
                            REFERENCE TRUST AGREEMENT

     This Reference Trust Agreement dated April 25, 2000 between DEAN WITTER
REYNOLDS INC., as Depositor, and The Chase Manhattan Bank, as Trustee, sets
forth certain provisions in full and incorporates other provisions by
reference to the document entitled "Sears Equity Investment Trust, Trust
Indenture and Agreement" dated January 22, 1991, as amended on March 16,
1993, July 18, 1995 and December 30, 1997 (the "Basic Agreement"). Such
provisions as are incorporated by reference constitute a single instrument
(the "Indenture").

                                WITNESSETH THAT:

     In consideration of the premises and of the mutual agreements herein
contained, the Depositor and the Trustee agree as follows:

                                       I.

                     STANDARD TERMS AND CONDITIONS OF TRUST

              Subject to the provisions of Part II hereof, all the
provisions contained in the Basic Agreement are herein incorporated by reference
in their entirety and shall be deemed to be a part of this instrument as fully
and to the same extent as though said provisions had been set forth in full in
this instrument except that the Basic Agreement is hereby amended in the
following manner:

               A. Article I, Section 1.01, paragraph (29) defining "Trustee"
          shall be amended as follows:

          "'Trustee' shall mean The Chase Manhattan Bank, or any successor
               trustee appointed as hereinafter provided."

               B.  Reference to United States Trust Company of New York in its
          capacity as Trustee is replaced by The Chase Manhattan Bank throughout
          the Basic Agreement.

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               C.  Reference to "Dean Witter Select Equity Trust" is replaced by
          "Morgan Stanley Dean Witter Select Equity Trust".

               D. Section 3.01 is amended to substitute the following:

                           SECTION  3.01.  INITIAL COST The costs of organizing
               the Trust and sale of the Trust Units shall, to the extent of the
               expenses reimbursable to the Depositor provided below, be borne
               by the Unit Holders, provided, HOWEVER, that, to the extent all
               of such costs are not borne by Unit Holders, the amount of such
               costs not borne by Unit Holders shall be borne by the Depositor
               and, PROVIDED FURTHER, HOWEVER, that the liability on the part of
               the Depositor under this section shall not include any fees or
               other expenses incurred in connection with the administration of
               the Trust subsequent to the deposit referred to in Section 2.01.
               Upon notification from the Depositor that the primary offering
               period is concluded, the Trustee shall withdraw from the Account
               or Accounts specified in the Prospectus or, if no Account is
               therein specified, from the Principal Account, and pay to the
               Depositor the Depositor's reimbursable expenses of organizing the
               Trust and sale of the Trust Units in an amount certified to the
               Trustee by the Depositor. If the balance of the Principal Account
               is insufficient to make such withdrawal, the Trustee shall, as
               directed by the Depositor, sell Securities identified by the
               Depositor, or distribute to the Depositor Securities having a
               value, as determined under Section 4.01 as of the date of
               distribution, sufficient for such reimbursement. The
               reimbursement provided for in this section shall be for the
               account of the Unitholders of record at the conclusion of the
               primary offering period and shall not be reflected in the
               computation of the Unit Value prior thereto. As used herein, the
               Depositor's reimbursable expenses of organizing the Trust and
               sale of the Trust Units shall include the cost of the initial
               preparation and typesetting of the registration statement,
               prospectuses (including preliminary prospectuses), the indenture,
               and other documents relating to the Trust, SEC and state blue sky
               registration fees, the cost of the ini-

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               tial valuation of the portfolio and audit of the Trust, the
               initial fees and expenses of the Trustee, and legal and other
               out-of-pocket expenses related thereto, but not including the
               expenses incurred in the printing of preliminary prospectuses
               and prospectuses, expenses incurred in the preparation and
               printing of brochures and other advertising materials and any
               other selling expenses. Any cash which the Depositor has
               identified as to be used for reimbursement of expenses
               pursuant to this Section shall be reserved by the Trustee for
               such purpose and shall not be subject to distribution or,
               unless the Depositor otherwise directs, used for payment of
               redemptions in excess of the per-Unit amount allocable to
               Units tendered for redemption.

                                       II.

                      SPECIAL TERMS AND CONDITIONS OF TRUST

                    The following special terms and conditions are hereby agreed
to:

                    A. The Trust is denominated Morgan Stanley Dean Witter
               Select Equity Trust Strategic Growth Large-Cap Portfolio 2000-2
               (the "Strategic Growth Trust").

                    B. The publicly traded stocks listed in Schedule A hereto
               are those which, subject to the terms of this Indenture, have
               been or are to be deposited in trust under this Indenture.

                    C. The term, "Depositor" shall mean Dean Witter Reynolds
               Inc.

                    D. The aggregate number of Units referred to in Sections
               2.03 and 9.01 of the Basic Agreement is 25,639 for the Strategic
               Growth Trust.

                    E. A Unit is hereby declared initially equal to 1/25,639th
               for the Strategic Growth Trust.

                    F. The term "In-Kind Distribution Date" shall mean,
               July 9, 2001.

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                    G. The term "Record Dates" shall mean December 1, 2000 and
               July 27, 2001 and such other date as the Depositor may direct.

                    H. The term "Distribution Dates" shall mean December 15,
               2000 and on or about August 3, 2001 and such other date as the
               Depositor may direct.

                    I. The term "Termination Date" shall mean July 27, 2001.

                    J. The Depositor's Annual Portfolio Supervision Fee shall be
               a maximum of $0.25 per 100 Units.

                    K. The Trustee's annual fee as defined in Section 6.04 of
               the Indenture shall be $.90 per 100 Units if the greatest number
               of Units outstanding during the period is 10,000,000 or more;
               $.96 per 100 Units if the greatest number of Units outstanding
               during the period is between 5,000,000 and 9,999,999; and $1.00
               per 100 Units if the greatest number of Units outstanding during
               the period is 4,999,999 or less.

                    L. For a Unit Holder to receive an "in--kind" distribution
               during the life of the Trust, such Unit Holder must tender at
               least 25,000 Units for redemption.  There is no minimum amount of
               Units that a Unit Holder must tender in order to receive an
               "in-kind" distribution on the In-Kind Date or in connection with
               a rollover.

                    M.  Paragraph (b)(ii) of Section 9.03 is amended to provide
               that the period during which the Trustee shall liquidate the
               Trust Securities shall not exceed 14 business days commencing on
               the first business day following the In-Kind Date.

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                  (Signatures and acknowledgments on separate pages)

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          The Schedule of Portfolio Securities in the prospectus included in
this Registration Statement is hereby incorporated by reference herein as
Schedule A hereto.<PAGE>

                                                           EXHIBIT 10.109

                                 AMENDMENT NO. 2
                                       TO
             STRUCTURED EQUITY LINE FLEXIBLE FINANCING(SM) AGREEMENT

     THIS AMENDMENT NO. 2 to STRUCTURED EQUITY LINE FLEXIBLE FINANCING(SM)
AGREEMENT ("Amendment") is dated as of March 27, 2000 between Cripple Creek
Securities, LLC (the "Investor"), and Cygnus, Inc., a corporation organized and
existing under the laws of the State of Delaware (the "Company"). Capitalized
terms not defined herein shall have the meanings assigned to them in that
certain Structured Equity Line Flexible Financing(SM) Agreement dated as of June
30, 1999, as amended September 29, 1999 (the "Agreement"), between the Company
and the Investor.

                              W I T N E S S E T H :

     WHEREAS, the Company and the Investor entered into the Agreement, pursuant
to which the Company may issue to the Investor, and the Investor shall purchase
from the Company, from time to time as provided therein, shares of the Company's
common stock, par value $0.001 per share (the "Common Stock"), for a maximum
aggregate Purchase Price of $30,000,000 (the "Maximum Offering Amount"); and

     WHEREAS, the Company and the Investor desire to amend the Agreement
effective as of April 1, 2000, as provided herein, so as to increase the amount
the Company may issue to the Investor, and the Investor shall purchase from the
Company, in any Investment Period beginning on or after April 1, 2000;

     NOW, THEREFORE, in consideration of the foregoing premises and other
good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto agree as follows:

                                    ARTICLE I

                                    AGREEMENT

     Section 1.1 Effective as of April 1, 2000, Section 2.1(b) of the Agreement
is hereby amended and restated in its entirety as follows:

     "(b) MANDATORY MONTHLY PURCHASES AT COMPANY'S ELECTION. If the Company, in
its sole discretion, elects to deliver a Mandatory Purchase Notice with respect
to any Investment Period in accordance with Section 2.3(a), then upon the
Company's delivery of such Mandatory Purchase Notice, the Investor shall be
obligated in such Investment Period to purchase ("Mandatory Purchase") from the
Company shares of Common Stock during such Investment Period for an aggregate
Purchase Price to be specified by the Company in the Mandatory Purchase Notice,
but not to exceed $1,000,000, subject to the adjustments and limitations imposed
by this Agreement (the "Minimum Obligation"). Upon receipt of a Mandatory
Purchase Notice, subject to the terms and conditions contained herein, the
Investor shall be obligated to

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purchase on one or more Closing Dates in respect of each such Mandatory Purchase
Date or Mandatory Purchase Dates as the Investor elects during the Investment
Period, shares of Common Stock for an aggregate Purchase Price equal to the
Minimum Obligation."

     Section 1.2 Effective as of April 1, 2000, Section 2.1(c) of the Agreement
is hereby amended and restated in its entirety as follows:

     "(c) ADDITIONAL AMOUNTS AT THE COMPANY'S ELECTION. For any Investment
Period during which the Company elects to obligate the Investor to make a
Mandatory Purchase, the Company may deliver to the Investor an Additional
Purchase Notice with respect to the same Investment Period in accordance with
Section 2.3(b). Upon any such delivery of an Additional Purchase Notice with
respect to an Investment Period, the Investor shall be obligated to purchase
shares of Common Stock from the Company (in addition to the Minimum Obligation)
during such Investment Period for an aggregate Purchase Price to be specified by
the Company in the Additional Purchase Notice, but not to exceed $3,000,000
(which individual purchases shall be at least $50,000 and multiples of $50,000
in excess thereof), subject to the adjustments and limitations imposed by this
Agreement (the "Additional Amount"). Upon receipt of such Additional Purchase
Notice, the Investor shall be obligated to purchase on each Closing Date in
respect of each such Additional Purchase Date or Additional Purchase Dates as
the Investor elects during the Investment Period to which such Additional
Purchase Notice relates, shares of Common Stock for an aggregate Purchase Price
equal to the Additional Amount."

     Section 1.3 Effective as of April 1, 2000, Section 2.1(d) of the Agreement
is hereby amended and restated in its entirety as follows:

     "(d) INVESTOR CALL. For any Investment Period with respect to which the
Company has timely delivered a Mandatory Purchase Notice, the Investor may
deliver to the Company an Investor Call Purchase Notice or Notices during such
Investment Period, subject to the Company's right to limit or cancel the
Investor Call Amount pursuant to Section 2.3(a)(ii) and Section 2.3(a)(iii).
Upon delivery of such an Investor Call Purchase Notice, the Company shall be
obligated to sell shares of Common Stock to the Investor (in addition to the
Minimum Obligation and the Additional Amount, if any) during the corresponding
Investment Period for an aggregate Purchase Price to be specified by the
Investor in the Investor Call Purchase Notice, but not to exceed an aggregate of
$3,000,000 for any Investment Period (which individual purchases shall be at
least $50,000 and multiples of $50,000 in excess thereof), subject to
adjustments and limitations imposed by this Agreement (the "Investor Call
Amount"). Upon delivery of such Investor Call Purchase Notice, the Investor
shall be obligated to purchase on each Closing Date in respect of each such Call
Purchase Date or Call Purchase Dates as the Investor elects during the
Investment Period to which such Investor Call Purchase Notice relates, shares of
Common Stock for an aggregate Purchase Price equal to the Investor Call Amount."

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                                   ARTICLE II

                                  MISCELLANEOUS

     Section 2.1 NO THIRD PARTY BENEFICIARIES. This Amendment is intended for
the benefit of the parties hereto and their respective permitted successors and
assigns and is not for the benefit of, nor may any provision hereof be enforced
by, any other person.

     Section 2.2 GOVERNING LAW. This Amendment shall be governed by and
construed and enforced in accordance with the internal laws of the State of New
York without regard to such state's principles of conflict of laws.

     Section 2.3 EXECUTION. This Amendment may be executed in two or more
counterparts, all of which shall be considered one and the same agreement, it
being understood that all parties need not sign the same counterpart.

     Section 2.4 Except as amended hereby, the Agreement shall remain unchanged
and in full force and effect.

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     IN WITNESS WHEREOF, the parties hereto have caused this Amendment No. 2 to
Structured Equity Line Flexible Financing(SM) Agreement to be duly executed by
their respective authorized officers as of the date hereof.

CRIPPLE CREEK SECURITIES, LLC               CYGNUS, INC.

By:  /S/ ROBERT CHENDER                     By:  /S/ CRAIG W. CARLSON
   --------------------------------------      ---------------------------------
     Name:  Robert L. Chender                    Name:  Craig Carlson
     Title:  Principal                           Title:  Chief Financial Officer

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