Document:

Software License Agreement

 EXHIBIT 10.45 
  
 Execution Version 
  
 SOFTWARE LICENSE AGREEMENT 
  
 This Software License Agreement (hereinafter referred to as the “Agreement”) is made this 29th day of March, 2004, by and between CADMUS KNOWLEDGEWORKS INTERNATIONAL LTD., a company incorporated under the laws of Mauritius having its
registered office at c/o Abacus Financial Services (Mauritius) Limited, Third Floor, TM Building, Pope Hennessy Street, Port Louis, Republic of Mauritius (hereinafter referred to as “Licensor”) and KNOWLEDGEWORKS GLOBAL
PRIVATE LIMITED, a company incorporated in India under the Companies Act, 1956 having its registered office at Knowledge Centre, Street No. 17, MIDC, Andheri (East), Mumbai 400 093, India (hereinafter referred to as
“Customer”). 
  
 Background 
  
 A.        Licensor will become the
registered and beneficial owner of eighty percent (80.0%) of the total paid up equity share capital of Customer. 
  
 B.        Customer is in the business of providing content management, content processing and other services.

  
 C.        Licensor is
the owner of certain proprietary software and tools more particularly described in Schedule 1 ( hereinafter referred to as the “Software”). 
  
 D.        Customer desires to obtain from Licensor, and Licensor agrees to grant to
Customer, a non-exclusive and non-transferable license to use the Software in accordance with the terms of this Agreement and as agreed to by the Licensor and Customer from time-to-time. 
  
 Agreement 
  
 Accordingly, in consideration of the mutual promises and agreements contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Licensor and Customer agree as follows: 
  
 1.      License Grant.    Subject to the terms and conditions of this Agreement, Licensor hereby grants to the Customer a non-exclusive and non-transferable license to use the
Software in accordance with the terms of this Agreement and such other terms as may be agreed to by the Licensor and Customer from time-to-time, for an unlimited number of users and/or concurrent devices and to load and store the said Software
solely for its own business purposes. “Concurrent device “ is each terminal, monitor or input device being used to access network at a given point in time. If multiplexing software or hardware is used, number of concurrent devices must be
measured as the number of terminals, monitors or input devices being used at the multiplexing front end. Customer shall not use the said Software for commercial time sharing, rental or service bureau use involving any person or entity. Except to the
extent needed to use and operate the said Software for its own business purposes, the Customer agrees not to cause or permit reverse engineering, disassembly or de-compilation of the said Software. Customer agrees not to remove any product
identification, copyright notices, or other notices or proprietary restrictions from the said Software. Customer may make copies of the said Software for back up purposes. 
  
 2.      Delivery of Software.    Licensor shall provide Customer one
executable copy of the Software (including each improvement), by way of electronic transmission, for use by Customer and, upon satisfactory downloading, the Customer shall promptly acknowledge receipt of the said Software (or improvement).

  

 1 

 Execution Version 
  

	3.      Royalty	Payments 

  
 (a)        Amount.    In consideration of the license granted herein, Customer will pay
Licensor a royalty (the “Royalty”) equal to (a) two percent (2%) of Customer’s Net Sales of goods and services relating to export sales (but excluding for this purpose any sales to Cadmus Professional Communications or
any other affiliate of Cadmus Communications Corporation), and (b) one percent (1%) of Customer’s Net Sales of goods and services relating to Indian domestic sales; where “Net Sales” means gross sales less
agents’/dealers’ commission, transport cost, including ocean freight, insurance, duties, taxes and other charges, and costs of raw materials, parts, and components imported from a foreign supplier or its subsidiary/affiliated company
provided that in no event shall the Royalty exceed the maximum amount permitted to be paid under applicable law. The parties hereto shall annually review the rate of Royalty set forth hereinabove, no later than 30 days following each anniversary of
this Agreement, during the term, to ensure that the percentage of Royalty payable hereunder reflects at all times the arm’s length value of the rights granted to the Customer under this Agreement. In the event that the parties hereto determine,
by mutual agreement, any change in the percentage of Royalty payable by the Customer under this Agreement then an appropriate amendment to this Agreement shall be executed in writing by the parties hereto to reflect such change in the percentage of
Royalty payable by the Customer to the Licensor under this Agreement. 
  
 (b)        Reporting.    Customer will provide Licensor with a monthly statement in a format agreeable to Licensor, itemizing the Royalty payable, within 30 days following
the end of each month. In addition this monthly statement shall also include the rate at which tax will be deducted at source on the Royalty payable and the amount of such deduction. Each monthly report will be accompanied by a statement signed by
an authorised officer of Customer certifying that the report is accurate, correct and complete and prepared in compliance with this Agreement. 
  
 (c)        Payment.    Customer and Licensor will agree from time-to-time during the
term of this Agreement upon appropriate procedures, mechanics and timing for payment of the Royalty by Customer to Licensor. For example, but without limitation, Customer could pay the Royalty to Licensor contemporaneously with each statement; or
Customer could pay the Royalty to Licensor periodically when Licensor’s Board of Directors meet to agree upon final arrangements for settlement of intercompany receivables; or Customer and Licensor could agree upon any other procedure that is
mutually satisfactory to them. Time is of the essence with respect to all royalty payments made hereunder. It is understood between the parties hereto that all payments due and payable under this Agreement shall be made by the Customer, to the
Licensor, subject to deduction of tax at source, as applicable under Indian laws and any such deduction shall not increase the amount of Royalty that the Customer is obliged to pay under this Agreement as set forth in Section 3(a). If Customer
defaults or fails to make payment when such obligation is due in accordance with their aforesaid agreement, Customer will pay Licensor interest on such past-due amount at the rate of 1.5% per month from the date such payment was due until such
payment is received by Licensor, and for this purpose Customer will obtain all such approvals as may be required in order to enable Customer to pay the amount of interest to Licensor. All payments due and payable hereunder will be made by Customer
in United States Dollars or such other currency as Customer and Licensor may mutually agree. 
  
 (d)        Books and Records.    Customer will keep accurate books of account and records at its principal place of business covering all transactions
relating to this Agreement, for at least three years after the payment of the corresponding Royalty, and Licensor will have the right, at all reasonable hours of the day, to audit Customer’s books of account and records on five days’ prior
notice. 
  

 2 

 Execution Version 
  
 (e)        Training and Installation:    Licensor
shall provide all assistance, training and support services in connection with the said Software, as agreed to by the parties hereto, using qualified, trained and experienced personnel. Licensor shall also provide training, maintenance and related
support to Customer to the extent Licensor, in its sole discretion, determines necessary to carry forward the purpose of this Agreement. 
  
 4.      Term.    The term of this Agreement will begin on the date of this Agreement and will continue for
a term of three (3) years. Thereafter, the term of this Agreement will be extended automatically for successive one year terms unless either party hereto provides the other party with written notice of non-renewal. 
  
 5.      Confidentiality.    Customer agrees that neither Customer, its agents nor its employees shall in any manner use, disclose or otherwise communicate any information with
respect to the Software which might enable copying of all or any portion of the Software. Customer agrees to take all necessary action to protect the confidential and proprietary information included in the Software, including appropriate
instruction and agreement with its employees. 
  
 6.      Title.    Customer agrees that, as between Customer and Licensor, Licensor owns all copyright, trade secret, patent, trademark and other proprietary rights in and to
the Software, including all modifications and improvements thereto. Customer further agrees and accepts that the use of the Software by it in accordance with the terms hereof shall not be deemed to vest in it, in any manner whatsoever, any right,
title or interest in the Software, or the intellectual property contained therein. All and any modifications or improvements to the Software made by the employees of Customer or its agents having access to the Software (or resulting from their use
of the Software) shall be for the benefit of the Licensor and the Licensor shall be the sole and exclusive owner of all such modifications or improvements to the Software. Customer covenants that it shall not at any time do or cause to be done any
act or thing, directly or indirectly, contesting or in way impairing any part of Licensor’s right in or to the Software whether during the subsistence of this Agreement or at any time thereafter. 
  
 7.      WARRANTIES.    THE
SOFTWARE IS PROVIDED TO CUSTOMER “AS IS, WHERE IS,” AND LICENSOR MAKES NO WARRANTIES REGARDING THE SOFTWARE, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES AS TO MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. LICENSOR
SHALL NOT BE LIABLE FOR ANY LOSS OF PROFITS, LOSS OF USE, OR INTERRUPTION OF BUSINESS, OR FOR INDIRECT, SPECIAL, CONSEQUENTIAL, INCIDENTAL, OR EXEMPLARY DAMAGES OF ANY KIND, WHETHER ARISING DUE TO THE USE OF THE SOFTWARE OR UNDER THIS AGREEMENT OR
OTHERWISE. 
  

	8.      General	Provisions 

  
 a.        Assignability.    This Agreement and all rights and obligations hereunder
shall not be assignable by Customer except with the prior written consent of Licensor. A change in control of Customer shall be deemed an assignment subject to this Section. This Agreement shall be binding upon each party’s permitted successors
and assigns. 
  
 b.        Liability.    Neither party hereto shall be liable for special, indirect, incidental or consequential damages, whether arising from contract or negligence. No
action or claim relating to this Agreement or the Software may be instituted more than one (1) year after the event giving rise to such action or claim. 
  

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 Execution Version 
  
 c.        Entire Agreement; Amendment.    This Agreement with its
exhibits is the complete and exclusive agreement of the parties hereto and supersedes all other communications, oral or written, between the parties hereto relating to this Agreement’s subject matter. Any change to this Agreement shall not be
valid unless it is in writing and signed by both parties hereto. 
  
 d.        Choice of Law.    This Agreement shall be governed by the laws of India, without regard to its conflict of laws provisions.  
  
 e.        Default.    In
the event of any default of any obligation by a party hereto under this Agreement which remains uncured fifteen (15) days after receipt of written notice of such default by the other party hereto, the non-defaulting party may terminate this
Agreement. If this Agreement is terminated, all outstanding amounts will immediately become due and payable and Customer shall return all copies of the Software to Licensor and erase any copies residing in any machine. Customer shall also be
responsible for procuring and/ or ensuring that its agents or its employees, or other parties having access to the Software forthwith return to Licensor all copies of the Software in its possession or under its control or in the possession or
control of it’s agents or employees, or other parties having access to the Software, including but not limited to all back up copies or alternately at the instructions of the Licensor destroy all copies of the Software and erase any copies
residing in any machine. On termination of this Agreement, the Customer shall also cease and desist from using the Software in any manner and shall also be responsible for procuring and/ or ensuring that it’s agents or its employees, or other
parties having access to the Software also cease and desist from using the Software in any manner. 
  
 f.        Waiver.    Neither the failure nor any delay of either party hereto to exercise a right, remedy or privilege under this Agreement shall
operate as a waiver thereof, nor shall any single or partial exercise of a right, remedy or privilege preclude any further exercise of the same. 
  
 g.        Severability.    A determination that any provision of this Agreement is invalid, illegal or
unenforceable shall not affect the enforceability of any other provision. 
  
 h.        Notices.    All notices and other communications required under this Agreement shall be in writing and shall be deemed to have been received when personally
delivered or may be sent by facsimile, registered mail by first class, postage prepaid, addressed as set forth at the end of this Agreement or such other addresses as the parties hereto may specify from time to time. 
  
 i.        Counterparts.    This Agreement may be executed in any number of counterparts and by different parties hereto in separate counterparts, each of which when so
executed and delivered shall be deemed to be an original and all of which taken together shall constitute but one and the same agreement. 
  
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 Execution Version 
  
  
 IN WITNESS WHEREOF the Parties hereto have
executed these presents on the day and year first hereinabove written: 
  
 CADMUS KNOWLEDGEWORKS INTERNATIONAL, LTD. 
  

			
		
	By:	 	/s/ Christopher T. Schools
		
	Name:	 	Christopher T. Schools
		
	Its:	 	Director

  

	Address:	c/o Abacus Financial Services (Mauritius) Limited 

 Third
Floor 
 TM Building 
 Pope
Hennessy Street 
 Port Louis, Republic of Mauritius 
  

KNOWLEDGEWORKS GLOBAL PRIVATE LIMITED 
  

			
		
	By:	 	/s/ Lalit S. Kanodia
		
	Name:	 	Dr. Lalit S Kanodia
		
	Its:	 	Director

  

	Address:	Knowledge Centre 

 Street No. 17, MIDC 
 Andheri (East), Mumbai 400 093 
 India

  

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 Execution Version 
  

The schedule to this agreement is omitted from this filing pursuant to Regulation S-K, Item 601(b). The Company agrees to supplementally furnish a copy
of such schedule to the Commission upon request. 
  

 6Amended and Restated 2000 Equity Incentive Plan

 Exhibit 4.1 
  

PHARSIGHT CORPORATION 
  
 AMENDED AND RESTATED 2000 EQUITY INCENTIVE PLAN 
  
 Adopted by Board of Directors April 7, 2000 
 Approved by Stockholders June 4, 2000 
 Amended by Board of Directors July 29, 2002 
 Approved by Stockholders September 6, 2002 
 Amended by Board of Directors June 13, 2003 
 Amended by Board of Directors July 17, 2003 
 Amended by Board of Directors April 22, 2004 
 Approved by Stockholders August 12, 2004 
  
 Effective
Date: Date of Initial Public Offering 
 Termination Date: April 7, 2010 
  

	1.	PURPOSES. 

  
 (a) Eligible Stock Award Recipients. The persons eligible to receive Stock Awards are the Employees, Directors and Consultants of the
Company and its Affiliates. 
  
 (b) Available Stock
Awards. The purpose of the Plan is to provide a means by which eligible recipients of Stock Awards may be given an opportunity to benefit from increases in value of the Common Stock through the granting of the following Stock Awards: (i)
Incentive Stock Options, (ii) Nonstatutory Stock Options, (iii) stock bonuses and (iv) rights to acquire restricted stock. The Plan also provides for non-discretionary grants of Nonstatutory Stock Options to Non-Employee Directors of the Company.

  
 (c) General Purpose. The Company, by means of
the Plan, seeks to retain the services of the group of persons eligible to receive Stock Awards, to secure and retain the services of new members of this group and to provide incentives for such persons to exert maximum efforts for the success of
the Company and its Affiliates. 
  

	2.	DEFINITIONS. 

  
 (a) “Affiliate” means any parent corporation or subsidiary corporation of the Company, whether now or hereafter existing,
as those terms are defined in Sections 424(e) and (f), respectively, of the Code. 
  
 (b) “Board” means the Board of Directors of the Company. 
  
 (c) “Cause” means the occurrence of any one or more of the following: (i) the Participant’s conviction of any felony or any
crime involving moral turpitude or dishonesty which results in material harm to the business of the Company; (ii) the Participant’s participation in a fraud or act of dishonesty against the Company which results in material harm to the business
of the Company; or (iii) the Participant’s intentional, material violation of any material contract between the Company and the Participant or any statutory duty the Participant owes to the Company that the Participant does not correct within
thirty (30) days after written notice 

  

 1. 

 
thereof has been provided to the Participant and which results in material harm to the business of the Company. 
  
 (d) “Change in Control” means the occurrence
of any one or more of the following: 
  
 (i)
a Corporate Transaction after which persons who were not stockholders of the Company immediately prior to such Corporate Transaction own, directly or indirectly, immediately following such Corporate Transaction, fifty percent (50%) or more of
the outstanding voting power of each of (a) the continuing or surviving entity and (b) any direct or indirect parent corporation of the continuing or surviving entity; 
  
 (ii) after the IPO Date, an acquisition by any person, entity or group within the meaning of Section
13(d) or 14(d) of the Exchange Act, or any comparable successor provisions (excluding any employee benefit plan, or related trust, sponsored or maintained by the Company or an Affiliate) of the beneficial ownership (within the meaning of Rule 13d-3
promulgated under the Exchange Act, or comparable successor rule) of securities of the Company representing at least fifty percent (50%) of the combined voting power entitled to vote in the election of Directors; provided that such acquisition does
not occur in connection with, in contemplation of or as a result of a Corporate Transaction; or 
  
 (iii) after the IPO Date, during any consecutive two (2) year period the individuals who, as of the start of such period, are
members of the Board (the “Incumbent Board”), cease for any reason to constitute at least fifty percent (50%) of the Board, provided that such change in the Incumbent Board does not occur in connection with, in contemplation of or as a
result of a Corporate Transaction, and further provided that if the election, or nomination for election, by the Company’s stockholders of any new Director was approved by a vote of at least fifty percent (50%) of the Incumbent Board, such new
Director shall be considered as a member of the Incumbent Board. 
  
 (e) “Code” means the Internal Revenue Code of 1986, as amended. 
  
 (f) “Committee” means a committee of one or more members of the Board appointed by the Board in accordance with subsection
3(c). 
  
 (g) “Common Stock” means
the common stock of the Company. 
  
 (h)
“Company” means Pharsight Corporation, a Delaware corporation. 
  
 (i) “Consultant” means any person, including an advisor, (i) engaged by the Company or an Affiliate to render consulting or advisory services and who is compensated for such services or
(ii) who is a member of the Board of Directors of an Affiliate. However, the term “Consultant” shall not include either Directors who are not compensated by the Company for their services as Directors or Directors who are merely paid a
director’s fee by the Company for their services as Directors. 
  
 (j) “Continuous Service” means that the Participant’s service with the Company or an Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. The Participant’s
Continuous Service shall not be deemed to have terminated merely because of 

  

 2. 

 
a change in the capacity in which the Participant renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the
entity for which the Participant renders such service, provided that there is no interruption or termination of the Participant’s Continuous Service. For example, a change in status from an Employee of the Company to a Consultant of an
Affiliate or a Director will not constitute an interruption of Continuous Service. The Board or the chief executive officer of the Company, in that party’s sole discretion, may determine whether Continuous Service shall be considered
interrupted in the case of any leave of absence approved by that party, including sick leave, military leave or any other personal leave. 
  
 (k) “Corporate Transaction” means the occurrence of any one or more of the following: 
  
 (i) a sale, lease or other disposition of all or
substantially all of the securities or assets of the Company; 
  
 (ii) a merger or consolidation following which the Company is not the surviving corporation; 
  
 (iii) a reverse merger following which the Company is the surviving corporation but the shares of Common Stock outstanding
immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise; or 
  
 (iv) any other transaction described as a “corporate transaction” in Treasury Regulations §1.425-1(a)(1)(ii).

  
 (l) “Covered Employee” means
the chief executive officer and the four (4) other highest compensated officers of the Company for whom total compensation is required to be reported to stockholders under the Exchange Act, as determined for purposes of Section 162(m) of the Code.

  
 (m) “Director” means a member
of the Board of Directors of the Company. 
  
 (n)
“Disability” means the inability of a person, in the opinion of a qualified physician acceptable to the Company, to perform the major duties of that person’s position with the Company or an Affiliate because of the
sickness or injury of the person and such inability results in termination of employment by the Company or Affiliate. 
  
 (o) “Eligible Director” means a Non-Employee Director or any other Director who is not an Employee or Consultant at the
time of grant of an Nonstatutory Stock Option under section 7 hereof. 
  
 (p) “Employee” means any person employed by the Company or an Affiliate. Mere service as a Director or payment of a director’s fee by the Company or an Affiliate shall not be sufficient to constitute
“employment” by the Company or an Affiliate. 
  
 (q)
“Exchange Act” means the Securities Exchange Act of 1934, as amended. 
  

 3. 

 (r) “Fair Market Value” means, as of any date, the value of the Common
Stock determined as follows and in each case in a manner consistent with Section 260.140.50 of Title 10 of the California Code of Regulations: 
  
 (i) If the Common Stock is listed on any established stock exchange or traded on the Nasdaq National Market, the Nasdaq
SmallCap Market or the Over The Counter Bulletin Board system the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange, market or
system (or the exchange, market or system with the greatest volume of trading the Common Stock) on the last market trading day prior to determination, as reported in The Wall Street Journal or such other source as the Board deems reliable.

  
 (ii) In the absence of an established
market or system for the Common Stock, the Fair Market Value shall be determined in good faith by the Board. 
  
 (s) “Good Reason” means that one or more of the following are undertaken by the Company without the Participant’s
express written consent: (i) the assignment to the Participant of any duties or responsibilities that results in a diminution in the Participant’s position or function as in effect immediately prior to the effective date of the Change in
Control; provided, however, that a mere change in the Participant’s title or reporting relationships shall not constitute Good Reason; (ii) a reduction by the Company in the Participant’s annual base salary, as in effect on the
effective date of the Change in Control; (iii) any failure by the Company to continue in effect any benefit plan or program, including incentive plans or plans with respect to the receipt of securities of the Company, in which the Participant was
participating immediately prior to the effective date of the Change in Control (hereinafter referred to as “Benefit Plans”), or the taking of any action by the Company that would adversely affect the Participant’s participation in or
reduce the Participant’s benefits under the Benefit Plans or deprive the Participant of any fringe benefit that the Participant enjoyed immediately prior to the effective date of the Change in Control; provided, however, that Good Reason
shall not be deemed to have occurred if the Company provides for the Participant’s participation in benefit plans and programs that, taken as a whole, are comparable to the Benefit Plans; (iv) a relocation of the Participant’s business
office to a location more than thirty (30) miles from the location at which the Participant performs duties as of the effective date of the Change in Control, except for required travel by the Participant on the Company’s business to an extent
substantially consistent with the Participant’s business travel obligations prior to the Change in Control; (v) a material breach by the Company of any provision of the Plan or the Stock Award Agreement or any other material agreement between
the Participant and the Company concerning the terms and conditions of the Participant’s employment; or (vi) any failure by the Company to obtain the assumption of the Plan and Stock Award Agreement by any successor or assign of the Company.

  
 (t) “Incentive Stock Option”
means an Option intended to qualify as an incentive stock option within the meaning of Section 422 of the Code and the regulations promulgated thereunder. 
  
 (u) “Independent Director” means each Director of the Company who is (i) not an Employee of the Company, (ii) is not acting
in the capacity of a Consultant to the Company, and 

  

 4. 

 
(iii) cannot exercise, individually or in affiliation with any entity or group of entities that exercises, voting control over more than 20% of the
Company’s voting stock. 
  
 (v) “IPO
Date” means the effective date of the Company’s Form S-1 Registration Statement filed under the Securities Act in connection with the initial public offering of the Common Stock. 
  
 (w) “Non-Employee Director” means a Director
who either (i) is not a current Employee or Officer of the Company or its parent or a subsidiary, does not receive compensation (directly or indirectly) from the Company or its parent or a subsidiary for services rendered as a consultant or in any
capacity other than as a Director (except for an amount as to which disclosure would not be required under Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act (“Regulation S-K”)), does not possess an interest in any
other transaction as to which disclosure would be required under Item 404(a) of Regulation S-K and is not engaged in a business relationship as to which disclosure would be required under Item 404(b) of Regulation S-K; or (ii) is otherwise
considered a “non-employee director” for purposes of Rule 16b-3. 
  
 (x) “Non-Employee Director Option” shall have the meaning subscribed in section 7 hereof. 
  
 (y) “Non-Employee Director Option Agreement” means a written agreement between the Company and an Eligible Director,
evidencing the terms and conditions of a Non-Employee Director Option grant. Each Non-Employee Director Option Agreement shall be subject to the terms and conditions of the Plan. 
  
 (z) “Nonstatutory Stock Option” means an Option not intended to qualify as an Incentive Stock
Option. 
  
 (aa) “Officer” means a
person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 
  
 (bb) “Option” means an Incentive Stock Option or a Nonstatutory Stock Option granted pursuant to the Plan. 
  
 (cc) “Option Agreement” means a written
agreement between the Company and an Optionholder evidencing the terms and conditions of an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of the Plan. 
  
 (dd) “Optionholder” means a person to whom an
Option is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option. 
  
 (ee) “Outside Director” means a Director who either (i) is not a current employee of the Company or an “affiliated
corporation” (within the meaning of Treasury Regulations promulgated under Section 162(m) of the Code), is not a former employee of the Company or an “affiliated corporation” receiving compensation for prior services (other than
benefits under a tax qualified pension plan), was not an officer of the Company or an “affiliated corporation” at any time and is not currently receiving direct or indirect remuneration from the Company or an 

  

 5. 

 
“affiliated corporation” for services in any capacity other than as a Director or (ii) is otherwise considered an “outside director” for
purposes of Section 162(m) of the Code. 
  
 (ff)
“Participant” means a person to whom a Stock Award is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Stock Award. 
  
 (gg) “Plan” means this Pharsight Corporation Amended and Restated 2000 Equity Incentive Plan.

  
 (hh) “Predecessor Plans” means
the Company’s 1995 Stock Option Plan and the 1997 Stock Option Plan. 
  
 (ii) “Rule 16b-3” means Rule 16b-3 promulgated under the Exchange Act or any successor to Rule 16b-3, as in effect from time to time. 
  
 (jj) “Securities Act” means the Securities Act
of 1933, as amended. 
  
 (kk) “Stock
Award” means any right granted under the Plan, including an Option, a Non-Employee Director Option, a stock bonus and a right to acquire restricted stock. 
  
 (ll) “Stock Award Agreement” means a written agreement between the Company and a holder of a
Stock Award evidencing the terms and conditions of an individual Stock Award grant. Each Stock Award Agreement shall be subject to the terms and conditions of the Plan. 
  
 (mm) “Ten Percent Stockholder” means a person who owns (or is deemed to own pursuant to
Section 424(d) of the Code) stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or of any of its Affiliates. 
  

	3.	ADMINISTRATION. 

  
 (a) Administration by Board. The Board shall administer the Plan unless and until the Board delegates administration to a Committee, as
provided in subsection 3(c). 
  
 (b) Powers of
Board. The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan: 
  
 (i) To determine from time to time which of the persons eligible under the Plan shall be granted Stock Awards; when and how each
Stock Award shall be granted; what type or combination of types of Stock Award shall be granted; the provisions of each Stock Award granted (which need not be identical), including the time or times when a person shall be permitted to receive Common
Stock pursuant to a Stock Award; and the number of shares of Common Stock with respect to which a Stock Award shall be granted to each such person. 
  
 (ii) To construe and interpret the Plan and Stock Awards granted under it, and to establish, amend and revoke rules and regulations
for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Stock Award Agreement, in a manner and to the extent it shall deem necessary or expedient to make the Plan
fully effective. 
  

 6. 

 (iii) To amend the Plan or a Stock Award as provided in Section 13. 
  
 (iv) Generally, to exercise such powers and to
perform such acts as the Board deems necessary or expedient to promote the best interests of the Company which are not in conflict with the provisions of the Plan. 
  
 (c) Delegation to Committee. 
  
 (i) General. The Board may delegate administration of the Plan to a Committee or Committees of
one (1) or more members of the Board, and the term “Committee” shall apply to any person or persons to whom such authority has been delegated. If administration is delegated to a Committee, the Committee shall have, in connection with the
administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board shall
thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Board may abolish the Committee at any time and revest in
the Board the administration of the Plan. 
  
 (ii) Committee Composition when Common Stock is Publicly Traded. At such time as the Common Stock is publicly traded, in the discretion of the Board, a Committee may consist solely of two or more Outside Directors, in
accordance with Section 162(m) of the Code, and/or solely of two or more Non-Employee Directors, in accordance with Rule 16b-3. Within the scope of such authority, the Board or the Committee may (1) delegate to a committee of one or more members of
the Board who are not Outside Directors the authority to grant Stock Awards to eligible persons who are either (a) not then Covered Employees and are not expected to be Covered Employees at the time of recognition of income resulting from such Stock
Award or (b) not persons with respect to whom the Company wishes to comply with Section 162(m) of the Code and/or) (2) delegate to a committee of one or more members of the Board who are not Non-Employee Directors the authority to grant Stock Awards
to eligible persons who are not then subject to Section 16 of the Exchange Act. 
  
 (d) Effect of Board’s Decision. All determinations, interpretations and constructions made by the Board in good faith shall not be subject to review by any person and shall be final, binding and
conclusive on all persons. 
  

	4.	SHARES SUBJECT TO THE PLAN. 

  
 (a) Share Reserve. Subject to the provisions of Section 12
relating to adjustments upon changes in stock and Section 4(d) below, the Common Stock that may be issued pursuant to Stock Awards shall not exceed in the aggregate six million four hundred twelve thousand seven hundred fifty seven (6,412,757)
shares of Common Stock (the “Reserved Shares”). As of each January 1, beginning with January 1, 2004 and continuing through and including January 1, 2010 (the “Anniversary Date”), the number of Reserved Shares will be increased
automatically by the least of (i) 5 % of the total number of share of Common Stock outstanding on such Anniversary Date, (ii) two million (2,000,000) shares, (iii) such fewer number of shares as 

  

 7. 

 
determined by the Board prior to such Anniversary Date or (iv) such fewer number of shares as permitted pursuant to Section 4(d) below. 
  
 (b) Reversion of Shares to the Share Reserve. If any Stock
Award shall for any reason expire or otherwise terminate, in whole or in part, without having been exercised in full, the shares of Common Stock not acquired under such Stock Award shall revert to and again become available for issuance under the
Plan. 
  
 (c) Source of Shares. The shares of Common
Stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or otherwise. 
  
 (d) Reserve Limitation. Notwithstanding Section 4(a), if at the time of each grant of a Stock Award under the Plan, the Company is subject
to Section 260.140.45 of Title 10 of the California Code of Regulations (“Section 260.140.45”), the total number of securities issuable upon exercise of all outstanding options of the Company and the total number of shares provided for
under this Plan or any other equity incentive, stock bonus or similar plan or agreement of the Company or outside any such plan shall not exceed 30% of the then outstanding capital stock of the Company (as measured as set forth in Section
260.140.45), unless stockholder approval to exceed 30% has been obtained in compliance with Section 260.140.45, in which case the limit shall be such higher percentage as approved by the stockholders. 
  

	5.	ELIGIBILITY. 

  
 (a) Eligibility for Specific Stock Awards. Incentive Stock Options may be granted only to Employees. Stock Awards other than Incentive Stock
Options may be granted to Employees, Directors (whether or not eligible for grants pursuant to Section 7 hereof) and Consultants. 
  
 (b) Ten Percent Stockholders. 
  
 (i) A Ten Percent Stockholder shall not be granted an Option unless the exercise price of such Option is at least one hundred ten
percent (110%) of the Fair Market Value of the Common Stock at the date of grant and the Option is not exercisable after the expiration of five (5) years from the date of grant. 
  
 (ii) So long as the Company is subject to Section 260.140.41 of Title 10 of the California Code of
Regulations, a Ten Percent Stockholder shall not be granted a restricted stock award unless the purchase price of the restricted stock is at least (A) one hundred percent (100%) of the Fair Market Value of the Common Stock on the date of grant or
(B) such lower percentage of the Fair Market Value of the Common Stock on the date of grant as is permitted by Section 260.140.41 of Title 10 of the California Code of Regulations at the time of the grant of the restricted stock award. 

 
 (c) Section 162(m) Limitation. Subject to the provisions of
Section 12 relating to adjustments upon changes in the shares of Common Stock, no Employee shall be eligible to be granted Options covering more than Five Hundred Thousand (500,000) shares of Common Stock during any calendar year. 
  

 8. 

 (d) Consultants. 
  
 (i) A Consultant shall not be eligible for the grant of a Stock Award if, at the time of grant, a
Form S-8 Registration Statement under the Securities Act (“Form S-8”) is not available to register either the offer or the sale of the Company’s securities to such Consultant because of the nature of the services that the Consultant
is providing to the Company, or because the Consultant is not a natural person, or as otherwise provided by the rules governing the use of Form S-8, unless the Company determines both (i) that such grant (A) shall be registered in another manner
under the Securities Act (e.g., on a Form S-3 Registration Statement) or (B) does not require registration under the Securities Act in order to comply with the requirements of the Securities Act, if applicable, and (ii) that such grant
complies with the securities laws of all other relevant jurisdictions. 
  
 (ii) Form S-8 generally is available to consultants and advisors only if (i) they are natural persons; (ii) they provide bona fide services to the issuer, its parents, its majority-owned subsidiaries or
majority-owned subsidiaries of the issuer’s parent; and (iii) the services are not in connection with the offer or sale of securities in a capital-raising transaction, and do not directly or indirectly promote or maintain a market for the
issuer’s securities. 
  

	6.	OPTION PROVISIONS. 

  
 Each Option shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. All Options shall be separately
designated Incentive Stock Options or Nonstatutory Stock Options at the time of grant, and, if certificates are issued, a separate certificate or certificates will be issued for shares of Common Stock purchased on exercise of each type of Option.
The provisions of separate Options need not be identical, but each Option shall include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of each of the following provisions: 
  
 (a) Term. Subject to the provisions of subsection 5(b)
regarding Ten Percent Stockholders, no Option shall be exercisable after the expiration of ten (10) years from the date it was granted. 
  
 (b) Exercise Price of an Incentive Stock Option. Subject to the provisions of subsection 5(b) regarding Ten Percent Stockholders, the
exercise price of each Incentive Stock Option shall be not less than one hundred percent (100%) of the Fair Market Value of the Common Stock subject to the Option on the date the Option is granted. 
  
 (c) Exercise Price of a Nonstatutory Stock Option. Subject to
the provisions of subsection 5(b) regarding Ten Percent Stockholders, the exercise price of each Nonstatutory Stock Option shall be not less than eighty-five percent (85%) of the Fair Market Value of the Common Stock subject to the Option on the
date the Option is granted. 
  
 (d) Consideration.
The purchase price of Common Stock acquired pursuant to an Option shall be paid, to the extent permitted by applicable statutes and regulations, either (i) in cash at the time the Option is exercised or (ii) at the discretion of the Board at the
time of the grant of the Option (or subsequently in the case of a Nonstatutory Stock Option) (1) by delivery to the Company of other Common Stock, (2) according to a deferred payment or other similar 

  

 9. 

 
arrangement with the Optionholder or (3) in any other form of legal consideration that may be acceptable to the Board. Unless otherwise specifically provided
in the Option, the purchase price of Common Stock acquired pursuant to an Option that is paid by delivery to the Company of other Common Stock acquired, directly or indirectly from the Company, shall be paid only by shares of the Common Stock of the
Company that have been held for more than six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting purposes). At any time that the Company is incorporated in Delaware, payment of the
Common Stock’s “par value,” as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 
  
 (e) Transferability of an Incentive Stock Option. An Incentive Stock Option shall not be transferable except by will or by the laws of
descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing, the Optionholder may, by delivering written notice to the Company, in a form satisfactory to the
Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 
  
 (f) Transferability of a Nonstatutory Stock Option. A Nonstatutory Stock Option shall be transferable to the extent provided in the Option
Agreement; provided however, to the extent that the Company is subject to Section 260.140.41(d) of Title 10 of the California Code of Regulations at the time of the grant of the Nonstatutory Stock Option, the Nonstatutory Stock Option shall not be
transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. If the Nonstatutory Stock Option does not provide for transferability, then the
Nonstatutory Stock Option shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing, the Optionholder
may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 
  
 (g) Vesting Generally. The total number of shares of Common
Stock subject to an Option may, but need not, vest and therefore become exercisable in periodic installments that may, but need not, be equal. The Option may be subject to such other terms and conditions on the time or times when it may be exercised
(which may be based on performance or other criteria) as the Board may deem appropriate. The vesting provisions of individual Options may vary. The provisions of this subsection 6(g) are subject to any Option provisions governing the minimum number
of shares of Common Stock as to which an Option may be exercised. Notwithstanding the foregoing, to the extent that the Company is subject to the following restrictions on vesting under Section 260.140.41(f) of Title 10 of the California Code of
Regulations at the time of the grant of the Option, then options granted to an Employee who is not an Officer, Director or Consultant on the date of grant shall provide for vesting of the total number of shares of Common Stock at a rate of at least
twenty percent (20%) per year over five (5) years from the date the Option was granted, subject to reasonable conditions such as continued employment. 
  
 (h) Termination of Continuous Service. In the event an Optionholder’s Continuous Service terminates (other than upon the
Optionholder’s death or Disability), the Optionholder 

  

 10. 

 
may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination) but only within such
period of time ending on the earlier of (i) the date three (3) months following the termination of the Optionholder’s Continuous Service (or such longer or shorter period specified in the Option Agreement, which period, for so long as the
Company is subject to Section 260.140.41 of Title 10 of the California Code of Regulations, shall not be less than thirty (30) days unless such termination is for Cause), or (ii) the expiration of the term of the Option as set forth in the Option
Agreement. If, after termination, the Optionholder does not exercise his or her Option within the time specified in the Option Agreement, the Option shall terminate. 
  
 (i) Extension of Termination Date. An Optionholder’s Option Agreement may also provide that if the
exercise of the Option following the termination of the Optionholder’s Continuous Service (other than upon the Optionholder’s death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock would
violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in subsection 6(a) or (ii) the expiration of a period of three (3) months after
the termination of the Optionholder’s Continuous Service during which the exercise of the Option would not be in violation of such registration requirements. 
  
 (j) Disability of Optionholder. In the event that an Optionholder’s Continuous Service terminates as a
result of the Optionholder’s Disability, the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination), but only within such period of time ending on the
earlier of (i) the date twelve (12) months following such termination (or such longer or shorter period specified in the Option Agreement, which period, for so long as the Company is subject to Section 260.140.41 of Title 10 of the California Code
of Regulations, shall not be less than six (6) months) or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option within the time specified
herein, the Option shall terminate. 
  
 (k) Death of
Optionholder. In the event (i) an Optionholder’s Continuous Service terminates as a result of the Optionholder’s death or (ii) the Optionholder dies within the period (if any) specified in the Option Agreement after the termination of
the Optionholder’s Continuous Service for a reason other than death, then the Option may be exercised (to the extent the Optionholder was entitled to exercise such Option as of the date of death) by the Optionholder’s estate, by a person
who acquired the right to exercise the Option by bequest or inheritance or by a person designated to exercise the Option upon the Optionholder’s death pursuant to subsection 6(e) or 6(f), but only within the period ending on the earlier of (1)
the date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement, which period, for so long as the Company is subject to Section 260.140.41 of Title 10 of the California Code of
Regulations, shall not be less than six (6) months) or (2) the expiration of the term of such Option as set forth in the Option Agreement. If, after death, the Option is not exercised within the time specified herein, the Option shall terminate.

  

 11. 

 (l) Early Exercise. The Option may, but need not, include a provision whereby the
Optionholder may elect at any time before the Optionholder’s Continuous Service terminates to exercise the Option as to any part or all of the shares of Common Stock subject to the Option prior to the full vesting of the Option. Subject to the
“Repurchase Limitation” in Section 11(g), any unvested shares of Common Stock so purchased may be subject to a repurchase option in favor of the Company or to any other restriction the Board determines to be appropriate. 
  
 (m) Re-Load Options. 
  
 (i) Without in any way limiting the authority of the
Board to make or not to make grants of Options hereunder, the Board shall have the authority (but not an obligation) to include as part of any Option Agreement a provision entitling the Optionholder to a further Option (a “Re-Load Option”)
in the event the Optionholder exercises the Option evidenced by the Option Agreement, in whole or in part, by surrendering other shares of Common Stock in accordance with this Plan and the terms and conditions of the Option Agreement. Unless
otherwise specifically provided in the Option, the Optionholder shall not surrender shares of Common Stock acquired, directly or indirectly from the Company, unless such shares have been held for more than six (6) months (or such longer or shorter
period of time required to avoid a charge to earnings for financial accounting purposes). 
  
 (ii) Any such Re-Load Option shall (1) provide for a number of shares of Common Stock equal to the number of shares of Common Stock
surrendered as part or all of the exercise price of such Option; (2) have an expiration date which is the same as the expiration date of the Option the exercise of which gave rise to such Re-Load Option; and (3) have an exercise price which is equal
to one hundred percent (100%) of the Fair Market Value of the Common Stock subject to the Re-Load Option on the date of exercise of the original Option. Notwithstanding the foregoing, a Re-Load Option shall be subject to the same exercise price and
term provisions heretofore described for Options under the Plan. 
  
 (iii) Any such Re-Load Option may be an Incentive Stock Option or a Nonstatutory Stock Option, as the Board may designate at the time of the grant of the original Option; provided, however, that the designation
of any Re-Load Option as an Incentive Stock Option shall be subject to the one hundred thousand dollar ($100,000) annual limitation on the exercisability of Incentive Stock Options described in subsection 11(d) and in Section 422(d) of the Code.
There shall be no Re-Load Options on a Re-Load Option. Any such Re-Load Option shall be subject to the availability of sufficient shares of Common Stock under subsection 4(a) and the “Section 162(m) Limitation” on the grants of Options
under subsection 5(c) and shall be subject to such other terms and conditions as the Board may determine which are not inconsistent with the express provisions of the Plan regarding the terms of Options. 
  

	7.	NON-EMPLOYEE DIRECTOR STOCK OPTIONS 

  
 Without any further action from the Board, Eligible Directors and
Independent Directors shall be granted Nonstatutory Stock Options in accordance with subsections 7(a) and 7(b) (collectively, the “Non-Employee Director Options”). Each Non-Employee Director Option shall include the substance of the terms
set forth in subsection 7(c) through 7(k) and such other terms and conditions as shall be determined by the Board as appropriate. 
  

 12. 

 (a) Initial Grants. After April 22, 2004, each Independent Director who is elected or
appointed to the Board, and each Director who was not previously an Independent Director who subsequently becomes an Independent Director, automatically shall be granted a Nonstatutory Stock Option to purchase One Hundred Thousand (100,000) shares
of Common Stock on the terms and conditions set forth herein (the “Initial Grant”) on the date such Independent Director is elected or appointed to the Board, or in the case of a Director who was not previously an Independent Director, on
the date such Director subsequently becomes an Independent Director. 
  
 (b) Annual Grants. On the day following each annual meeting of the stockholders of the Company (the “Annual Meeting”) commencing with the Annual Meeting in calendar year 2004, each person who is then an Eligible
Director automatically shall be granted a Nonstatutory Stock Option to purchase Ten Thousand (10,000) shares of Common Stock on the terms and conditions set forth herein (the “Annual Grant”). 
  
 (c) Term. Each Non-Employee Director Option shall have a term
of ten (10) years from the date it is granted. 
  
 (d)
Exercise Price. Subject to the provisions of Section 5(b) regarding Ten Percent Stockholders, the exercise price of each Non-Employee Director Option shall be one hundred percent (100%) of the Fair Market Value of the stock subject to the
Non-Employee Director Option on the date of grant. 
  
 (e)
Vesting. Non-Employee Director Options shall vest and become exercisable as follows: 
  
 (i) An Initial Grant shall vest in twenty-four (24) equal installments on each monthly anniversary of the date of the Initial
Grant; provided however, that the Director provides service to the Company through each such date; and provided further, that if a Change in Control occurs, then the vesting and exercisability of the Initial Grant shall be accelerated
in full. 
  
 (ii) An Annual Grant shall
vest in full on the day of the first anniversary of the Annual Meeting next following its date of grant; provided, however, that the Director provides service to the Company through each such date. 
  
 (f) Consideration. The purchase price of stock acquired
pursuant to a Non-Employee Director Option may be paid, to the extent permitted by applicable statutes and regulations, in any combination of (i) cash or check, (ii) delivery to the Company of other Common Stock owned by the Director for at least
six (6) months; (iii) deferred payment or (iv) any other form of legal consideration that may be acceptable to the Board and provided in the Non-Employee Director Option Agreement; provided, however, that at any time that the Company is incorporated
in Delaware, payment of the Common Stock’s “par value,” as defined in the Delaware Corporation Law, shall not be made by deferred payment. 
  
 (g) Transferability. A Non-Employee Director Option shall be transferable to the extent provided in the Non-Employee Director Option
Agreement; provided however, to the extent that the Company is subject to Section 260.140.41(d) of Title 10 of the California Code of Regulations at the time of the grant of the Non-Employee Director Option, the Eligible Director shall not be
transferable except by will or by the laws of descent and distribution and shall be 

  

 13. 

 
exercisable during the lifetime of the Eligible Director only by the Eligible Director. If the Non-Employee Director Option Agreement does not provide for
transferability, then the Non-Employee Director Option shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Eligible Director only by the Eligible Director.
Notwithstanding the foregoing, the Eligible Director may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Eligible Director, shall thereafter be
entitled to exercise the Non-Employee Director Option. 
  
 (h)
Termination of Continuous Service. In the event an Eligible Director’s Continuous Service terminates (other than upon the Eligible Director’s death or Disability), the Eligible Director may exercise his or her
Non-Employee Director Option (to the extent that the Eligible Director was entitled to exercise it as of the date of termination) but only within such period of time ending on the earlier of (i) the date six (6) months following the termination of
the Eligible Director’s Continuous Service, or (ii) the expiration of the term of the Non-Employee Director Option as set forth in the Non-Employee Director Option Agreement. If, after termination, the Eligible Director does not exercise his or
her Non-Employee Director Option within the time specified herein, the Non-Employee Director Option shall terminate. 
  
 (i) Extension of Termination Date. If the exercise of the Non-Employee Director Option following the termination of the Eligible
Director’s Continuous Service (other than upon the Eligible Director’s death or Disability) would be prohibited at any time solely because the issuance of shares would violate the registration requirements under the Securities Act, then
the Non-Employee Director Option shall terminate on the earlier of (i) the expiration of the term of the Non-Employee Director Option set forth in subsection 7(c) or (ii) the expiration of a period of three (3) months after the termination of the
Eligible Director’s Continuous Service during which the exercise of the Non-Employee Director Option would not violate such registration requirements. 
  
 (j) Disability of Eligible Director. In the event an Eligible Director’s Continuous Service terminates as a result of the
Eligible Director’s Disability, the Eligible Director may exercise his or her Non-Employee Director Option (to the extent that the Eligible Director was entitled to exercise it as of the date of termination), but only within such period of time
ending on the earlier of (i) the date twelve (12) months following such termination or (ii) the expiration of the term of the Non-Employee Director Option as set forth in the Non-Employee Director Option Agreement. If, after termination, the
Eligible Director does not exercise his or her Non-Employee Director Option within the time specified herein, the Non-Employee Director Option shall terminate. 
  

(k) Death of Eligible Director. In the event (i) an Eligible Director’s Continuous Service terminates as a result of the
Eligible Director’s death or (ii) the Eligible Director dies within the six-month period after the termination of the Eligible Director’s Continuous Service for a reason other than death, then the Non-Employee Director Option may be
exercised (to the extent the Eligible Director was entitled to exercise the Non-Employee Director Option as of the date of death) by the Eligible Director’s estate, by a person who acquired the right to exercise the Non-Employee Director Option
by bequest or inheritance or by a person designated to exercise the Non-Employee Director Option upon the Eligible Director’s death, but only within the period 

  

 14. 

 
ending on the earlier of (1) the date eighteen (18) months following the date of death or (2) the expiration of the term of such Non-Employee Director Option
as set forth in the Non-Employee Director Option Agreement. If, after death, the Non-Employee Director Option is not exercised within the time specified herein, the Non-Employee Director Option shall terminate. 
  

	8.	PROVISIONS OF STOCK AWARDS OTHER THAN OPTIONS.

  
 (a) Stock Bonus Awards. Each
stock bonus agreement shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. The terms and conditions of stock bonus agreements may change from time to time, and the terms and conditions of separate
stock bonus agreements need not be identical, but each stock bonus agreement shall include (through incorporation of provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions: 
  
 (i) Consideration. A stock bonus may be
awarded in consideration for past services actually rendered to the Company or an Affiliate for its benefit. 
  
 (ii) Vesting. Subject to the “Repurchase Limitation” in Section 11(g), shares of Common Stock awarded under the
stock bonus agreement may, but need not, be subject to a share reacquisition right in favor of the Company in accordance with a vesting schedule to be determined by the Board. 
  
 (iii) Termination of Participant’s Continuous Service. Subject to the “Repurchase
Limitation” in Section 11(g), in the event a Participant’s Continuous Service terminates, the Company may reacquire any or all of the shares of Common Stock held by the Participant which have not vested as of the date of termination under
the terms of the stock bonus agreement. 
  
 (iv) Transferability. Rights to acquire shares of Common Stock under a stock bonus agreement shall be transferable by the Participant only upon such terms and conditions as are set forth in the stock bonus agreement, as the
Board shall determine in its discretion, so long as Common Stock awarded under the stock bonus agreement remains subject to the terms of the stock bonus agreement; provided however, to the extent that the Company is subject to Section 260.140.41(d)
of Title 10 of the California Code of Regulations at the time of the award, such rights to acquire shares of Common Stock under a stock bonus agreement shall not be transferable except by will or by the laws of descent and distribution and shall be
exercisable during the lifetime of the Participant only by the Participant. 
  
 (b) Restricted Stock Purchase Awards. Each restricted stock purchase agreement shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. The terms and
conditions of the restricted stock purchase agreements may change from time to time, and the terms and conditions of separate restricted stock purchase agreements need not be identical, but each restricted stock purchase agreement shall include
(through incorporation of provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions: 
  
 (i) Purchase Price. Subject to the provisions of Section 5(b) regarding Ten Percent Stockholders, the purchase price under
each restricted stock purchase agreement shall be 

  

 15. 

 
such amount as the Board shall determine and designate in such restricted stock purchase agreement. The purchase price shall not be less than eighty-five
percent (85%) of the Common Stock’s Fair Market Value on the date such award is made or at the time the purchase is consummated. 
  
 (ii) Consideration. The purchase price of Common Stock acquired pursuant to the restricted stock purchase agreement shall be
paid either: (i) in cash at the time of purchase; (ii) at the discretion of the Board, according to a deferred payment or other similar arrangement with the Participant; or (iii) in any other form of legal consideration that may be acceptable to the
Board in its discretion; provided, however, that at any time that the Company is incorporated in Delaware, then payment of the Common Stock’s “par value,” as defined in the Delaware General Corporation Law, shall not be made by
deferred payment. 
  
 (iii)
Vesting. Subject to the “Repurchase Limitation” in Section 11(g), shares of Common Stock acquired under the restricted stock purchase agreement may, but need not, be subject to a share repurchase option in favor of the Company
in accordance with a vesting schedule to be determined by the Board. 
  
 (iv) Termination of Participant’s Continuous Service. Subject to the “Repurchase Limitation” in Section 11(g), in the event a Participant’s Continuous Service terminates, the Company
may repurchase or otherwise reacquire any or all of the shares of Common Stock held by the Participant which have not vested as of the date of termination under the terms of the restricted stock purchase agreement. 
  
 (v) Transferability. Rights to acquire shares
of Common Stock under a restricted stock purchase agreement shall be transferable by the Participant only upon such terms and conditions as are set forth in the restricted stock purchase agreement, as the Board shall determine in its discretion, so
long as Common Stock awarded under the restricted stock purchase agreement remains subject to the terms of the restricted stock purchase agreement; provided however, to the extent that the Company is subject to Section 260.140.41(d) of Title 10 of
the California Code of Regulations at the time of the award, such rights to acquire shares of Common Stock under a restricted stock purchase agreement shall not be transferable except by will or by the laws of descent and distribution and shall be
exercisable during the lifetime of the Participant only by the Participant. 
  

	9.	COVENANTS OF THE COMPANY. 

  
 (a) Availability of Shares. During the terms of the Stock Awards, the Company shall keep available at all
times the number of shares of Common Stock required to satisfy such Stock Awards. 
  
 (b) Securities Law Compliance. The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required to grant Stock Awards and to
issue and sell shares of Common Stock upon exercise of the Stock Awards; provided, however, that this undertaking shall not require the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable
pursuant to any such Stock Award. If, after reasonable efforts, the Company is unable 

  

 16. 

 
to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of
Common Stock under the Plan, the Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. 
  

	10.	USE OF PROCEEDS FROM STOCK. 

  
 Proceeds from the sale of Common Stock pursuant to Stock Awards shall
constitute general funds of the Company. 
  

	11.	MISCELLANEOUS. 

  
 (a) Acceleration of Exercisability and Vesting. The Board shall have the power to accelerate the time at which a Stock Award may first be
exercised or the time during which a Stock Award or any part thereof will vest in accordance with the Plan, notwithstanding the provisions in the Stock Award stating the time at which it may first be exercised or the time during which it will vest.

  
 (b) Stockholder Rights. No Participant shall be
deemed to be the holder of, or to have any of the rights of a holder with respect to, any shares of Common Stock subject to such Stock Award unless and until such Participant has satisfied all requirements for exercise of the Stock Award pursuant to
its terms. 
  
 (c) No Employment or other Service
Rights. Nothing in the Plan or any instrument executed or Stock Award granted pursuant thereto shall confer upon any Participant any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Stock Award was
granted or shall affect the right of the Company or an Affiliate to terminate (i) the employment of an Employee with or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant’s
agreement with the Company or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the state in which the Company or the Affiliate is
incorporated, as the case may be. 
  
 (d) Incentive
Stock Option $100,000 Limitation. To the extent that the aggregate Fair Market Value (determined at the time of grant) of Common Stock with respect to which Incentive Stock Options are exercisable for the first time by any Optionholder during
any calendar year (under all plans of the Company and its Affiliates) exceeds one hundred thousand dollars ($100,000), the Options or portions thereof which exceed such limit (according to the order in which they were granted) shall be treated as
Nonstatutory Stock Options. 
  
 (e) Investment
Assurances. The Company may require a Participant, as a condition of exercising or acquiring Common Stock under any Stock Award, (i) to give written assurances satisfactory to the Company as to the Participant’s knowledge and experience in
financial and business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together
with the purchaser representative, the merits and risks of exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Participant is acquiring Common Stock subject to the Stock Award for 

  

 17. 

 
the Participant’s own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and
any assurances given pursuant to such requirements, shall be inoperative if (1) the issuance of the shares of Common Stock upon the exercise or acquisition of Common Stock under the Stock Award has been registered under a then currently effective
registration statement under the Securities Act or (2) as to any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in the circumstances under the then applicable securities laws. The
Company may, upon advice of counsel to the Company, place legends on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends
restricting the transfer of the Common Stock. 
  
 (f)
Withholding Obligations. To the extent provided by the terms of a Stock Award Agreement, the Participant may satisfy any federal, state or local tax withholding obligation relating to the exercise or acquisition of Common Stock under a
Stock Award by any of the following means (in addition to the Company’s right to withhold from any compensation paid to the Participant by the Company) or by a combination of such means: (i) tendering a cash payment; (ii) authorizing the
Company to withhold shares of Common Stock from the shares of Common Stock otherwise issuable to the Participant as a result of the exercise or acquisition of Common Stock under the Stock Award, provided, however, that the Company shall not be
authorized to withheld shares of Common Stock in excess if the minimum statutory rates for federal or state tax purposes including payroll taxes; or (iii) delivering to the Company owned and unencumbered shares of Common Stock. 
  
 (g) Repurchase Limitation. The terms of any repurchase option
shall be specified in the Stock Award, and the repurchase price shall be the original purchase price. To the extent required by Section 260.140.41 and Section 260.140.42 of Title 10 of the California Code of Regulations at the time a Stock Award is
made, any repurchase option contained in a Stock Award granted to a person who is not an Officer, Director or Consultant shall be upon the terms described below: 
  
 (i) Fair Market Value. If the repurchase option gives the Company the right to repurchase the
shares of Common Stock upon termination of Continuous Status at not less than the Fair Market Value of the shares of Common Stock to be purchased on the date of termination of Continuous Status, then (A) the right to repurchase shall be exercised
for cash or cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of termination of Continuous Status (or in the case of shares of Common Stock issued upon exercise of Stock Awards after such date of
termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the Company and the Participant (for example, for purposes of satisfying the requirements of Section 1202(c)(3) of the Code regarding
“qualified small business stock”) and (B) the right terminates when the shares of Common Stock become publicly traded. 
  
 (ii) Original Purchase Price. If the repurchase option gives the Company the right to repurchase the shares of Common Stock
upon termination of Continuous Status at the lower of (A) the Fair Market Value of the shares of Common Stock on the date of repurchase or (B) their original purchase price, then (x) the right to repurchase at the original purchase price 

  

 18. 

 
shall lapse at the rate of at least twenty percent (20%) of the shares of Common Stock per year over five (5) years from the date the Stock Award is granted
(without respect to the date the Stock Award was exercised or became exercisable) and (y) the right to repurchase shall be exercised for cash or cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of
termination of Continuous Status (or in the case of shares of Common Stock issued upon exercise of Options after such date of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the
Company and the Participant (for example, for purposes of satisfying the requirements of Section 1202(c)(3) of the Code regarding “qualified small business stock”). 
  
 (h) Information Obligation. To the extent required by Section 260.140.46 of Title 10 of the California Code of
Regulations, the Company shall deliver financial statements to Participants at least annually. This Section 11(h) shall not apply to key Employees whose duties in connection with the Company assure them access to equivalent information. 

 

	12.	ADJUSTMENTS UPON CHANGES IN STOCK. 

  
 (a) Capitalization Adjustments. If any change is made
in the Common Stock subject to the Plan, or subject to any Stock Award, without the receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company), the Plan will be appropriately adjusted in the
class(es) and maximum number of securities subject to the Plan pursuant to subsection 4(a) and the maximum number of securities subject to award to any person pursuant to subsection 5(c), and the outstanding Stock Awards will be appropriately
adjusted in the class(es) and number of securities and price per share of Common Stock subject to such outstanding Stock Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. (The conversion of
any convertible securities of the Company shall not be treated as a transaction “without receipt of consideration” by the Company.) 
  
 (b) Dissolution or Liquidation. In the event of a dissolution or liquidation of the Company, then all outstanding Stock Awards shall
terminate immediately prior to such event. 
  
 (c)
Corporate Transaction. In the event of a Corporate Transaction, any surviving corporation or acquiring corporation may assume any Stock Awards outstanding under the Plan or may substitute similar stock awards (including an award to
acquire the same consideration paid to the stockholders pursuant to the Corporate Transaction). In the event any surviving corporation or acquiring corporation refuses to assume such Stock Awards or to substitute similar stock awards for those
outstanding under the Plan, then with respect to Stock Awards held by Participants whose Continuous Service has not terminated as of the effective date of the Corporate Transaction, the vesting of such Stock Awards (and, if applicable, the time
during which such Stock Awards may be exercised) shall be accelerated in full, and the Stock Awards shall terminate if not exercised (if applicable) at or prior to such effective date. With respect to any other Stock Awards outstanding under
the Plan, such Stock Awards shall terminate if not exercised (if applicable) prior the effective date of the Corporate Transaction. 
  

 19. 

 (d) Change in Control. If a Change in Control occurs and within thirteen (13) months after
the effective date of such Change in Control the Continuous Service of a Participant terminates due to an involuntary termination (not including death or Disability) without Cause or due to a voluntary termination with Good Reason, then the vesting
and exercisability of all Stock Awards held by such Participant shall be accelerated in full.  
  

	13.	AMENDMENT OF THE PLAN AND STOCK AWARDS. 

  
 (a) Amendment of Plan. The Board at any time, and from time to
time, may amend the Plan. However, except as provided in Section 12 relating to adjustments upon changes in Common Stock, no amendment shall be effective unless approved by the stockholders of the Company to the extent stockholder approval is
necessary to satisfy the requirements of Section 422 of the Code, Rule 16b-3 or any Nasdaq or securities exchange listing requirements. 
  
 (b) Stockholder Approval. The Board may, in its sole discretion, submit any other amendment to the Plan for stockholder approval, including,
but not limited to, amendments to the Plan intended to satisfy the requirements of Section 162(m) of the Code and the regulations thereunder regarding the exclusion of performance-based compensation from the limit on corporate deductibility of
compensation paid to certain executive officers. 
  
 (c)
Contemplated Amendments. It is expressly contemplated that the Board may amend the Plan in any respect the Board deems necessary or advisable to provide eligible Employees with the maximum benefits provided or to be provided under the
provisions of the Code and the regulations promulgated thereunder relating to Incentive Stock Options and/or to bring the Plan and/or Incentive Stock Options granted under it into compliance therewith. 
  
 (d) No Impairment of Rights. Rights under any Stock Award
granted before amendment of the Plan shall not be impaired by any amendment of the Plan unless (i) the Company requests the consent of the Participant and (ii) the Participant consents in writing. 
  
 (e) Amendment of Stock Awards. The Board at any time, and from
time to time, may amend the terms of any one or more Stock Awards; provided, however, that the rights under any Stock Award shall not be impaired by any such amendment unless (i) the Company requests the consent of the Participant and (ii) the
Participant consents in writing. 
  

	14.	TERMINATION OR SUSPENSION OF THE PLAN. 

  
 (a) Plan Term. The Board may suspend or terminate the Plan at
any time. Unless sooner terminated, the Plan shall terminate on the day before the tenth (10th) anniversary of the date the Plan is adopted by the Board or approved by the stockholders of the Company, whichever is earlier. No Stock Awards may be
granted under the Plan while the Plan is suspended or after it is terminated. 
  
 (b) No Impairment of Rights. Suspension or termination of the Plan shall not impair rights and obligations under any Stock Award granted while the Plan is in effect except with the written consent of the
Participant. 
  

 20. 

	15.	EFFECTIVE DATE OF PLAN. 

  
 The Plan shall become effective on the IPO Date, but no Stock Award shall be exercised (or, in the case of a stock bonus,
shall be granted) unless and until the Plan has been approved by the stockholders of the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 
  

	16.	CHOICE OF LAW. 

  
 The law of the State of California shall govern all questions concerning the construction, validity and interpretation of this Plan, without regard to
such state’s conflict of laws rules. 
  

 21.

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