Document:

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                                                                  Exhibit 10.33
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                         COMMON STOCK PURCHASE AGREEMENT

                                     between

                            LYNX THERAPEUTICS, INC.,
                             a Delaware corporation

                                       and

                             TAKARA SHUZO CO., LTD.,
                             a Japanese corporation

                                 ---------------

                         Dated as of September 25, 2002

                                 ---------------

================================================================================
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<TABLE>
<S>            <C>                                                           <C>
SECTION 1.     SALE AND ISSUANCE OF SHARES....................................1

        1.1    Sale and Issuance of Shares....................................1

        1.2    Payment of Purchase Price......................................1

        1.3    Transfer Taxes.................................................1

SECTION 2.     CLOSING; DELIVERY..............................................2

SECTION 3.     REPRESENTATIONS AND WARRANTIES OF COMPANY......................2

        3.1    Organization, Good Standing and Qualification..................2

        3.2    Authorization..................................................2

        3.3    Valid Issuance of Securities...................................2

        3.4    Legal Proceedings and Orders...................................2

SECTION 4.     REPRESENTATIONS AND WARRANTIES OF PURCHASER....................3

        4.1    Authorization..................................................3

        4.2    Purchase Entirely for Own Account..............................3

        4.3    Disclosure of Information......................................3

        4.4    Restricted Securities..........................................3

        4.5    No Public Market...............................................4

        4.6    Legends........................................................4

        4.7    Accredited Investor............................................4

SECTION 5.     CONDITIONS PRECEDENT TO OBLIGATION OF PURCHASER TO CLOSE.......4

        5.1    Accuracy of Representations and Warranties.....................4

        5.2    Performance....................................................4

        5.3    Shares Available...............................................4

SECTION 6.     CONDITIONS TO OBLIGATION OF COMPANY TO CLOSE...................4

        6.1    Accuracy of Representations and Warranties.....................5

        6.2    Performance....................................................5

        6.3    No Restraints..................................................5

SECTION 7.     MISCELLANEOUS PROVISIONS.......................................5

        7.1    Time of Essence................................................5

        7.2    Further Actions................................................5

        7.3    Publicity......................................................5

        7.4    Governing Law..................................................5

        7.5    Venue and Jurisdiction.........................................5

        7.6    Notices........................................................5
</TABLE>

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<TABLE>
<S>            <C>                                                           <C>
        7.7    Fees and Expenses..............................................6

        7.8    Attorneys' Fees................................................6

        7.9    Table of Contents and Headings.................................6

        7.10   Successors and Assigns.........................................6

        7.11   Severability...................................................6

        7.12   Entire Agreement...............................................6

        7.13   Waiver.........................................................6

        7.14   Amendments.....................................................6

        7.15   Corporate Securities Law.......................................7

        7.16   Confidentiality................................................7

        7.17   Interpretation of Agreement....................................7
</TABLE>

                                       A-2
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                         COMMON STOCK PURCHASE AGREEMENT

        THIS COMMON STOCK PURCHASE AGREEMENT (this "Agreement") is entered into
as of September 25, 2002, by and between TAKARA SHUZO CO., LTD., a Japanese
corporation having its principal office at SETA 3-4-1, Otsu, Shiga, 520-2193
JAPAN ("Purchaser"), and LYNX THERAPEUTICS, INC., a Delaware corporation, having
its principal office at 25861 Industrial Blvd., Hayward, California, USA (the
"Company").

                                    RECITALS

        WHEREAS, Company and Purchaser have entered into that certain
Collaboration Agreement effective as of the 1st day of October, 2000 (the
"Collaboration Agreement") for the right to use the Company's proprietary
technologies to manufacture, distribute and sell microarrays worldwide and to
provide Megasort(TM) and MPSS(TM) services to customers in Japan, China and
Korea;

        WHEREAS, the Company has authorized the sale and issuance of up to two
million forty thousand eight hundred sixteen (2,040,816) shares of its common
stock to purchase in a private placement; and

        WHEREAS, in connection with the Collaboration Agreement, the Company
desires to issue and sell such shares of its common stock to Purchaser, and
Purchaser desires to purchase such shares of Company's common stock on the terms
and conditions set forth in this Agreement.

        NOW, THEREFORE, in consideration of the foregoing recitals and the
following mutual promises and covenants, the parties hereto agree as follows:

                                    AGREEMENT

SECTION 1. SALE AND ISSUANCE OF STOCK

        1.1 SALE AND ISSUANCE OF COMMON STOCK. Subject to the terms and
conditions set forth in this Agreement and the Collaboration Agreement, on the
Closing Date (as defined below), the Company agrees to sell and issue to
Purchaser, and Purchaser agrees to purchase, the number of shares of the
Company's common stock (the "Shares") determined by dividing the applicable One
Million U.S. Dollars ($1,000,000) ("Purchase Price") by the current market price
per share of the Company's common stock. The "current market price per share"
shall be the average for ten (10) trading days immediately prior to September
25, 2002 of the average of the daily high and the daily low, as reported on the
Nasdaq National Market or other nationally-recognized primary market on which
the Company's common stock is traded.

        1.2 PAYMENT OF PURCHASE PRICE. The Purchase Price is payable by
Purchaser to the Company on the Closing Date by wire transfer of immediately
available funds to an account or

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accounts to be designated by the Company, or by bank certified or cashier's
check made payable to the Company.

        1.3 TRANSFER TAXES. Any transfer taxes, stamp duties, filing fees,
registration fees, recordation expenses, escrow fees or other similar taxes,
fees, charges or expenses incurred by the Company, Purchaser or any other party
in connection with the purchase or in connection with any of the other
transactions contemplated by this Agreement shall be borne and paid exclusively
by the party incurring such expenses.

SECTION 2. CLOSING; DELIVERY.

        The consummation of the transaction contemplated by this Agreement (the
"Closing") shall be held on the date hereof ("Closing Date"). The Closing shall
be held at the offices of Cooley Godward LLP, 3175 Hanover Street, Palo Alto,
California 94306-2155 or at such other time or place as Purchaser and the
Company may mutually agree. At the Closing, the Company shall cause to be issued
to Purchaser a stock certificate, in the name of Purchaser, representing the
Shares being purchased against receipt of the payment of the Purchase Price. The
Company shall deliver such stock certificate to Purchaser at the Closing or
promptly thereafter.

SECTION 3. REPRESENTATIONS AND WARRANTIES OF COMPANY.

        The Company hereby represents, warrants and covenants to Purchaser as
follows:

        3.1 ORGANIZATION, GOOD STANDING AND QUALIFICATION. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware and has all requisite corporate power and authority to
carry on its business as now conducted and as presently proposed to be
conducted. The Company is duly qualified to transact business and is in good
standing as a foreign corporation in each jurisdiction in which the failure to
so qualify would have a material adverse effect on its business or properties.

        3.2 AUTHORIZATION. All corporate action on the part of Company, its
officers, directors and stockholders necessary for the authorization, execution
and delivery of this Agreement, the performance of all obligations of Company
hereunder and the authorization, issuance and delivery of the Shares has been
taken or will be taken prior to the Closing, and this Agreement, when executed
and delivered will constitute valid and legally binding obligations of the
Company, enforceable against the Company in accordance with their terms, except
as limited by applicable bankruptcy, insolvency, reorganization, moratorium,
fraudulent conveyance and other laws of general application affecting
enforcement of creditors' rights generally, as limited by laws relating to the
availability of specific performance, injunctive relief or other equitable
remedies.

        3.3 VALID ISSUANCE OF COMMON STOCK. The Shares that are being purchased
by Purchaser hereunder, when issued, sold and delivered in accordance with the
terms hereof for the consideration expressed herein, will be duly and validly
authorized and issued, fully paid and nonassessable and free of restrictions on
transfer other than restrictions on transfer under this Agreement and applicable
state and federal securities laws.

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        3.4 LEGAL PROCEEDINGS AND ORDERS. There is no action, suit, proceeding
or investigation ("Legal Proceeding") pending or threatened against the Company
that questions the validity of this Agreement or the right of the Company to
enter into this Agreement or to consummate the transactions contemplated hereby,
nor is the Company aware of any basis for any of the forgoing. The Company is
neither a party nor subject to the provisions of any order, writ, injunction,
judgment or decree of any court or government agency or instrumentality that
would affect the ability of the Company to enter into this Agreement or to
consummate the transactions contemplated hereby.

SECTION 4. REPRESENTATIONS AND WARRANTIES OF PURCHASER

        Purchaser hereby represents, warrants and covenants to the Company as
follows:

        4.1 AUTHORIZATION. Purchase has full power and authority to enter into
this Agreement, and this Agreement, when executed and delivered, will constitute
valid and legally binding obligations of Purchaser, enforceable in accordance
with their terms, except as limited by applicable bankruptcy, insolvency,
reorganization, moratorium, fraudulent conveyance and any other laws of general
application affecting enforcement of creditors' rights generally, and as limited
by laws relating to the availability of a specific performance, injunctive
relief or other equitable remedies.

        4.2 PURCHASE ENTIRELY FOR OWN ACCOUNT. This Agreement is made with
Purchaser in reliance upon Purchaser's representation to the Company, which by
Purchaser's execution of this Agreement Purchaser hereby confirms, that the
Shares to be purchased by Purchaser will be acquired for investment for
Purchaser's own account, not as a nominee or agent, and not with a view to the
resale or distribution of any part thereof. Purchaser has no present intention
of selling, granting any participation in or otherwise distributing the same. By
executing this Agreement, Purchaser further represents that Purchaser does not
presently have any contract, undertaking, agreement or arrangement with any
person to sell, transfer or grant participations to such person or to any third
person, with respect to any of the Shares and Purchaser has not been formed for
the specific purpose of acquiring the Shares.

        4.3 RECEIPT OF INFORMATION. Purchaser has had an opportunity to discuss
the Company's business, management and financial affairs and the terms and
conditions of the offering of the Shares with the Company's management and has
had an opportunity to review the Company's facilities. Purchaser has also had an
opportunity to ask questions of and receive answers from the Company regarding
the terms and conditions of its investment. Purchaser understands that such
discussions, as well as the written information issued by the Company, were
intended to describe the aspects of the Company's business which it believes to
be material.

        4.4 RESTRICTED SECURITIES. Purchaser understands that the Shares have
not been, and will not be, registered under the Securities Act of 1933, as
amended (the "Securities Act"), by reason of a specific exemption from the
registration provisions of the Securities Act, which depends upon, among other
things, the bona fide nature of the investment intent and the accuracy of
Purchaser's representations as expressed herein. Purchaser understands that the
Shares are "restricted securities" under applicable U.S. federal and state
securities laws and that, pursuant to these laws, Purchaser must hold the Shares
indefinitely unless they are registered with the

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Securities and Exchange Commission and qualified by state authorities, or an
exemption from such registration and qualification requirements is available.
Purchaser further acknowledges that if an exemption from registration or
qualification is available, it may be conditioned on various requirements
including, but not limited to, the time and manner of sale, the holding period
for the Shares, and on requirements relating to the Company which are outside of
Purchaser's control, and which the Company is under no obligation and may not be
able to satisfy.

        4.5 LEGENDS. Purchaser understands that the Shares and any securities
issued in respect of or exchange for the Shares, may bear one or all of the
following legends:

               (a) "THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED,
ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SUCH ACT, OR
UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL OR OTHER EVIDENCE,
SATISFACTORY TO THE COMPANY AND ITS COUNSEL, THAT SUCH REGISTRATION IS NOT
REQUIRED."

               (b) Any legend required by the Blue Sky laws of any state to the
extent such laws are applicable to the shares represented by the certificate so
legended.

        4.6 ACCREDITED INVESTOR. Purchaser is either (a) an accredited investor
as defined in Rule 501(a) of Regulation D promulgated under the Act or (b) not
an accredited investor and neither such Investor nor any beneficiary of any
trust or any investment client for whose account such Investor is purchasing is
a citizen or resident of the United States or Canada, or any state, territory or
possession thereof, including but not limited to any estate of any such person,
or any corporation, partnership, trust or other entity created or existing under
the laws thereof, or any entity controlled or owned by any of the foregoing (a
"U.S. Person").

        4.7 INVESTMENT EXPERIENCE. Purchaser is experienced in evaluating and
investing in private placement transactions of securities of companies in a
similar stage of development and acknowledges that Purchaser is able to fend for
himself, herself or itself, can bear the economic risk of such investment and
has such knowledge and experience in financial and business matters that
Purchaser is capable of evaluating the merits and risks of the investment in the
Shares.

        4.8 FURTHER REPRESENTATION BY FOREIGN INVESTORS. If Purchaser is not a
U.S. Person, Purchaser hereby represents that Purchaser is satisfied as to the
full observance of the laws of Purchaser's jurisdiction in connection with any
invitation to subscribe for the Shares or any use of this Agreement, including
(i) the legal requirements of Purchaser's jurisdiction for the purchase of the
Shares, (ii) any foreign exchange restrictions applicable to such purchase,
(iii) any governmental or other consents that may need to be obtained and (iv)
the income tax and other tax consequences, if any, which may be relevant to the
purchase, holding, redemption, sale or transfer of the Shares. Purchaser's
subscription and payment for, and Purchaser's continued beneficial ownership of,
the Shares will not violate any applicable securities or other laws of
Purchaser's jurisdiction.

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SECTION 5. CONDITIONS PRECEDENT TO OBLIGATION OF PURCHASER TO CLOSE

        The obligation of Purchaser to purchase the Shares and otherwise
consummate the transactions that are contemplated by this Agreement is subject
to the satisfaction, as of the Closing Date, of the following conditions (any of
which may be waived by Purchaser in whole or in part):

        5.1 ACCURACY OF REPRESENTATIONS AND WARRANTIES. The representations and
warranties of the Company set forth in Section 3 shall be accurate and true in
all material respects on and as of the Closing Date.

        5.2 PERFORMANCE. All of the covenants and obligations that the Company
is required to perform or to comply with pursuant to this Agreement, at or prior
to the Closing, must have been duly performed and complied with in all material
respects.

        5.3 SHARES AVAILABLE. The Company shall have available under its Amended
and Restated Certificate of Incorporation sufficient authorized shares of
capital stock to issue and sell the Shares to Purchaser.

SECTION 6. CONDITIONS TO OBLIGATION OF THE COMPANY TO CLOSE

        The obligation of the Company to cause the Shares to be sold to
Purchaser and otherwise consummate the transactions that are contemplated by
this Agreement is subject to the satisfaction, as of the Closing Date, of the
following conditions (any of which may be waived by Company in whole or in
part):

        6.1 ACCURACY OF REPRESENTATIONS AND WARRANTIES. The representations and
warranties of Purchaser set forth in Section 4 shall be accurate and true in all
material respects on and as of the Closing Date.

        6.2 PERFORMANCE. All of the covenants and obligations that Purchaser is
required to perform or to comply with pursuant to this Agreement, at or prior to
the Closing, must have been duly performed and complied with in all material
respects.

        6.3 NO RESTRAINTS. No temporary restraining order, preliminary or
permanent injunction or other order preventing the consummation of the Purchase
shall have been issued by any court of competent jurisdiction and remain in
effect, and there shall not be any law, rule, regulation, order, judgment or
decree enacted or deemed applicable to the Purchase that makes consummation of
the Purchase illegal.

        6.4 QUALIFICATIONS. All authorizations, approvals or permits, if any, of
any governmental authority or regulatory body of the United States or of any
state that are required in connection with the lawful issuance and sale of the
Shares pursuant to this Agreement shall be duly obtained and effective as of the
Closing.

SECTION 7. MISCELLANEOUS PROVISIONS

        7.1 TIME OF ESSENCE. Time is of the essence of this Agreement.

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        7.2 FURTHER ACTIONS. The Company shall execute such agreements and other
documents, and shall take such other actions, as Purchaser may reasonably
request (prior to, at or after the Closing) for the purpose of ensuring that the
transactions contemplated by this Agreement are carried out in full compliance
with the provisions of all applicable laws and regulations.

        7.3 PUBLICITY. No press release, publicity, disclosure or notice to any
Person concerning any of the transactions contemplated by this Agreement shall
be issued, given, made or otherwise disseminated at any time (whether prior to,
at or after the Closing) without the prior written approval of the other party.

        7.4 GOVERNING LAW. This Agreement shall be governed by the laws of the
State of California as such laws are applied to agreements between California
residents entered into and performed entirely in California.

        7.5 VENUE AND JURISDICTION. If any legal proceeding or other legal
action relating to this Agreement is brought or otherwise initiated, the venue
therefor shall be in California, which shall be deemed to be a convenient forum.
Purchaser and the Company hereby expressly and irrevocably consent and submit to
the jurisdiction of the courts in California.

        7.6 NOTICES. All notices and other communications under this Agreement
shall be in writing and shall be deemed effectively given: (a) upon personal
delivery to the party to be notified, (b) when sent by confirmed telex or
facsimile if sent during normal business hours, if not, then on the next
business day, (c) five days after having been sent by registered or certified
mail, return receipt requested, postage prepaid or (d) one day after deposit
with a nationally recognized overnight courier, specifying next day delivery,
with written verification of receipt. All communications shall be sent to the
addresses set forth on the signature page hereto or at such other address as the
Company or Purchaser may designate by ten days advance written notice to the
other parties thereto.

        7.7 FEES AND EXPENSES. All fees, costs and expenses incurred in
connection with the transactions contemplated by this Agreement shall be paid by
the party incurring such fees, costs and expenses.

        7.8 ATTORNEYS' FEES. In the event that any suit or action is instituted
to enforce any provision in this Agreement, the prevailing party in such dispute
shall be entitled to recover from the losing party all fees, costs and expenses
of enforcing any right of such prevailing party under or with respect to this
Agreement, including without limitation, such reasonable fees and expenses of
attorneys and accountants, which shall include, without limitation, all fees,
costs and expenses of appeals.

        7.9 TABLE OF CONTENTS AND HEADINGS. The table of contents of this
Agreement and the Section headings contained in this Agreement are for
convenience of reference only, shall not be deemed to be a part of this
Agreement and shall not be referred to in connection with the construction or
interpretation of this Agreement.

        7.10 SUCCESSORS AND ASSIGNS. Except as otherwise expressly provided
herein, the provisions hereof shall inure to the benefit of, and be binding
upon, the respective successors,

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assigns, heirs, executors and administrators of the parties hereto and shall
inure to the benefit of and be enforceable by each of the parties hereto.
Nothing in this Agreement, express or implied, is intended to confer upon any
party other than the parties hereto or their respective successors and assigns
any rights, remedies, obligations or liabilities under or by reason of this
Agreement, except as expressly provided in this Agreement.

        7.11 SEVERABILITY. In the event that any provision of this Agreement
shall be invalid, illegal or unenforceable, the validity, legality and
enforceability of the remaining provisions shall not in any way be affected or
impaired thereby.

        7.12 ENTIRE AGREEMENT. This Agreement and the Collaboration Agreement
referred to herein and therein constitute the entire agreement between the
parties hereto pertaining to the subject matter hereof, and any and all other
written or oral agreements existing between the parties hereto are expressly
canceled. This Agreement and the Collaboration Agreement are intended to define
the full extent of the legally enforceable undertakings of the Company and
Purchaser, and no promise or representation, whether written or oral, which is
not set forth explicitly in this Agreement or the Collaboration Agreement is
intended by either party to be legally binding.

        7.13 WAIVER. No failure on the part of either party hereto to exercise
any power, right, privilege or remedy under this Agreement, and no delay on the
part of either party hereto in exercising any power, right, privilege or remedy
under this Agreement, shall operate as a waiver thereof; and no single or
partial exercise of any such power, right, privilege or remedy shall preclude
any other or further exercise thereof or of any other power, right, privilege or
remedy.

        7.14 AMENDMENTS. This Agreement may not be amended, modified, altered or
supplemented except by means of a written instrument executed on behalf of both
Purchaser and the Company.

        7.15 CORPORATE SECURITIES LAW. THE SALE OF THE SECURITIES WHICH ARE THE
SUBJECT OF THIS AGREEMENT HAS NOT BEEN QUALIFIED WITH THE COMMISSIONER OF
CORPORATIONS OF THE STATE OF CALIFORNIA AND THE ISSUANCE OF THE SECURITIES OR
THE PAYMENT OR RECEIPT OF ANY PART OF THE CONSIDERATION THEREFOR PRIOR TO THE
QUALIFICATION IS UNLAWFUL, UNLESS THE SALE OF SECURITIES IS EXEMPT FROM THE
QUALIFICATION BY SECTION 25100, 25102 OR 25105 OF THE CALIFORNIA CORPORATIONS
CODE. THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT ARE EXPRESSLY CONDITIONED UPON
THE QUALIFICATION BEING OBTAINED UNLESS THE SALE IS SO EXEMPT.

        7.16 CONFIDENTIALITY. Each party hereto agrees that, except with the
prior written permission of the other party, it shall at all times keep
confidential and not in any way divulge, furnish or make accessible to anyone
any confidential information, knowledge or data concerning or relating to the
business or financial affairs of the other party to which such party has been or
shall become privy by reason of this Agreement, discussions or negotiations
relating to this Agreement, the performance of its obligations hereunder or the
ownership of the Shares purchased hereunder. The provisions of this Section 7.16
shall be in addition to, and not in

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substitution for, the provisions of any separate nondisclosure agreement
executed by the parties hereto with respect to the transactions contemplated
hereby.

        7.17 INTERPRETATION OF AGREEMENT.

               (a) Each party hereto acknowledges that it has participated in
the drafting of this Agreement, and any applicable rule of construction to the
effect that ambiguities are to be resolved against the drafting party shall not
be applied in connection with the construction or interpretation of this
Agreement.

               (b) Whenever required by the context hereof, the singular number
shall include the plural, and vice versa; the masculine gender shall include the
feminine and neuter genders; and the neuter gender shall include the masculine
and feminine genders.

               (c) As used in this Agreement, the words "include" and
"including," and variations thereof, shall not be deemed to be terms of
limitation, and shall be deemed to be followed by the words "without
limitation."

               (d) References herein to "Sections" and "Schedules" are intended
to refer to Sections of and Schedules to this Agreement.

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<PAGE>

        IN WITNESS WHEREOF, each of the parties hereto has caused this Common
Stock Purchase Agreement to be executed and delivered by its duly authorized
officer on the date set forth above.

                                       ACCEPTED AND ACKNOWLEDGED BY PURCHASER:

                                       TAKARA SHUZO CO., LTD.

                                       By:    /s/ Ikunoshin Kato
                                          --------------------------------------
                                       Printed Name:  Ikunoshin Kato
                                                    ----------------------------
                                       Title:  President, Biomedical Group
                                             -----------------------------------

                                       Address:    SETA 3-4-1
                                               ---------------------------------
                                                   Otsu, Shiga, 520-2193
                                               ---------------------------------
                                                   JAPAN
                                               ---------------------------------

                                       ACCEPTED AND ACKNOWLEDGED BY THE COMPANY:

                                       LYNX THERAPEUTICS, INC.

                                       By:  /s/ Edward C. Albini
                                          --------------------------------------
                                       Printed Name:  Edward C. Albini
                                                    ----------------------------
                                       Title:  Chief Financial Officer
                                             -----------------------------------

                                       Address:  25861 Industrial Boulevard
                                               ---------------------------------
                                                 Hayward, CA  94545
                                               ---------------------------------<PAGE>
                                                                   EXHIBIT 10.34

--------------------------------------------------------------------------------

                             LYNX THERAPEUTICS, INC.

                           LOAN AND SECURITY AGREEMENT

--------------------------------------------------------------------------------

<PAGE>

        This LOAN AND SECURITY AGREEMENT is entered into as of October 23, 2002,
by and between COMERICA BANK-CALIFORNIA ("Bank") and LYNX THERAPEUTICS, INC.
("Borrower").

                                    RECITALS

        Borrower wishes to obtain credit from time to time from Bank, and Bank
desires to extend credit to Borrower. This Agreement sets forth the terms on
which Bank will advance credit to Borrower, and Borrower will repay the amounts
owing to Bank.

                                    AGREEMENT

        The parties agree as follows:

        1. DEFINITIONS AND CONSTRUCTION.

               1.1 Definitions. As used in this Agreement, the following terms
shall have the following definitions:

                      "Accounts" means all presently existing and hereafter
arising accounts, contract rights, and all other forms of obligations owing to
Borrower arising out of the sale or lease of goods (including, without
limitation, the licensing of software and other technology) or the rendering of
services by Borrower, whether or not earned by performance, and any and all
credit insurance, guaranties, and other security therefor, as well as all
merchandise returned to or reclaimed by Borrower and Borrower's Books relating
to any of the foregoing.

                      "Affiliate" means, with respect to any Person, any Person
that owns or controls directly or indirectly such Person, any Person that
controls or is controlled by or is under common control with such Person, and
each of such Person's senior executive officers, directors, and partners.

                      "Bank Expenses" means all: reasonable costs or expenses
(including reasonable attorneys' fees and expenses) incurred in connection with
the preparation, negotiation, administration, and enforcement of the Loan
Documents; reasonable Collateral audit fees; and Bank's reasonable attorneys'
fees and expenses incurred in amending, enforcing or defending the Loan
Documents (including fees and expenses of appeal), incurred before, during and
after an Insolvency Proceeding, whether or not suit is brought.

                      "Borrower's Books" means all of Borrower's books and
records including: ledgers; records concerning Borrower's assets or liabilities,
the Collateral, business operations or financial condition; and all computer
programs, or tape files, and the equipment, containing such information.

                      "Business Day" means any day that is not a Saturday,
Sunday, or other day on which banks in the State of California are authorized or
required to close.

                      "Closing Date" means the date of this Agreement.

                      "Code" means the California Uniform Commercial Code.

                      "Collateral" means the property described on Exhibit A
attached hereto.

                      "Contingent Obligation" means, as applied to any Person,
any direct or indirect liability, contingent or otherwise, of that Person with
respect to (i) any indebtedness, lease, dividend, letter of credit or other
obligation of another, including, without limitation, any such obligation
directly or indirectly guaranteed, endorsed, co-made or discounted or sold with
recourse by that Person, or in respect of which that Person is otherwise
directly or indirectly liable; (ii) any obligations with respect to undrawn
letters of credit, corporate credit cards, or merchant services issued or
provided for the account of that Person; and (iii) all obligations arising under
any interest rate, currency or commodity swap agreement, interest rate cap
agreement, interest rate collar agreement, or other

                                       1
<PAGE>

agreement or arrangement designed to protect such Person against fluctuation in
interest rates, currency exchange rates or commodity prices; provided, however,
that the term "Contingent Obligation" shall not include endorsements for
collection or deposit in the ordinary course of business. The amount of any
Contingent Obligation shall be deemed to be an amount equal to the stated or
determined amount of the primary obligation in respect of which such Contingent
Obligation is made or, if not stated or determinable, the maximum reasonably
anticipated liability in respect thereof as determined by such Person in good
faith; provided, however, that such amount shall not in any event exceed the
maximum amount of the obligations under the guarantee or other support
arrangement.

                      "Copyrights" means any and all copyright rights, copyright
applications, copyright registrations and like protections in each work or
authorship and derivative work thereof, whether published or unpublished and
whether or not the same also constitutes a trade secret, now or hereafter
existing, created, acquired or held.

                      "Credit Extension" means each Equipment Advance, or any
other extension of credit by Bank for the benefit of Borrower hereunder.

                      "Daily Balance" means the amount of the Obligations owed
at the end of a given day.

                      "Equipment" means all present and future machinery,
equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and
attachments in which Borrower has any interest.

                      "Equipment Advance" has the meaning set forth in Section
2.1(a).

                      "Equipment Line" means a credit extension of up to Two
Million Dollars ($2,000,000).

                      "Equipment Maturity Date" means October 23, 2005.

                      "ERISA" means the Employee Retirement Income Security Act
of 1974, as amended, and the regulations thereunder.

                      "Event of Default" has the meaning assigned in Article 8.

                      "GAAP" means generally accepted accounting principles as
in effect from time to time.

                      "Indebtedness" means (a) all indebtedness for borrowed
money or the deferred purchase price of property or services, including without
limitation reimbursement and other obligations with respect to surety bonds and
letters of credit, (b) all obligations evidenced by notes, bonds, debentures or
similar instruments, (c) all capital lease obligations and (d) all Contingent
Obligations.

                      "Insolvency Proceeding" means any proceeding commenced by
or against any person or entity under any provision of the United States
Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law,
including assignments for the benefit of creditors, formal or informal
moratoria, compositions, extension generally with its creditors, or proceedings
seeking reorganization, arrangement, or other relief.

                      "Intellectual Property" means all of Borrower's right,
title, and interest in and to the following:

                      (a) Copyrights, Trademarks and Patents;

                      (b) Any and all trade secrets, and any and all
intellectual property rights in computer software and computer software products
now or hereafter existing, created, acquired or held;

                      (c) Any and all design rights which may be available to
Borrower now or hereafter existing, created, acquired or held;

                                       2
<PAGE>

                      (d) Any and all claims for damages by way of past, present
and future infringement of any of the rights included above, with the right, but
not the obligation, to sue for and collect such damages for said use or
infringement of the intellectual property rights identified above;

                      (e) All licenses or other rights to use any of the
Copyrights, Patents or Trademarks, and all license fees and royalties arising
from such use to the extent permitted by such license or rights;

                      (f) All amendments, renewals and extensions of any of the
Copyrights, Trademarks or Patents; and

                      (g) All proceeds and products of the foregoing, including
without limitation all payments under insurance or any indemnity or warranty
payable in respect of any of the foregoing.

                      "Inventory" means all present and future inventory in
which Borrower has any interest, including merchandise, raw materials, parts,
supplies, packing and shipping materials, work in process and finished products
intended for sale or lease or to be furnished under a contract of service, of
every kind and description now or at any time hereafter owned by or in the
custody or possession, actual or constructive, of Borrower, including such
inventory as is temporarily out of its custody or possession or in transit and
including any returns upon any accounts or other proceeds, including insurance
proceeds, resulting from the sale or disposition of any of the foregoing and any
documents of title representing any of the above, and Borrower's Books relating
to any of the foregoing.

                      "Investment" means any beneficial ownership of (including
stock, partnership interest or other securities) any Person, or any loan,
advance or capital contribution to any Person.

                      "IRC" means the Internal Revenue Code of 1986, as amended,
and the regulations thereunder.

                      "Lien" means any mortgage, lien, deed of trust, charge,
pledge, security interest or other encumbrance.

                      "Loan Documents" means, collectively, this Agreement, any
note or notes executed by Borrower, and any other agreement entered into in
connection with this Agreement, all as amended or extended from time to time.

                      "Material Adverse Effect" means a material adverse effect
on (i) the business operations, condition (financial or otherwise) or prospects
of Borrower and its Subsidiaries taken as a whole or (ii) the ability of
Borrower to repay the Obligations or otherwise perform its obligations under the
Loan Documents or (iii) the value or priority of Bank's security interests in
the Collateral.

                      "Negotiable Collateral" means all of Borrower's present
and future letters of credit of which it is a beneficiary, notes, drafts,
instruments, securities, documents of title, and chattel paper, and Borrower's
Books relating to any of the foregoing.

                      "Obligations" means all debt, principal, interest, Bank
Expenses and other amounts owed to Bank by Borrower pursuant to this Agreement
or any other agreement, whether absolute or contingent, due or to become due,
now existing or hereafter arising, including any interest that accrues after the
commencement of an Insolvency Proceeding and including any debt, liability, or
obligation owing from Borrower to others that Bank may have obtained by
assignment or otherwise.

                      "Patents" means all patents, patent applications and like
protections including without limitation improvements, divisions, continuations,
renewals, reissues, extensions and continuations-in-part of the same.

                                       3
<PAGE>

                      "Periodic Payments" means all installments or similar
recurring payments that Borrower may now or hereafter become obligated to pay to
Bank pursuant to the terms and provisions of any instrument, or agreement now or
hereafter in existence between Borrower and Bank.

                      "Permitted Indebtedness" means:

                      (a) Indebtedness of Borrower in favor of Bank arising
under this Agreement or any other Loan Document;

                      (b) Indebtedness existing on the Closing Date and
disclosed in the Schedule;

                      (c) Indebtedness secured by a lien i) upon or in any
equipment which was not financed by Bank acquired or held by Borrower or any of
its Subsidiaries to secure the purchase price of such equipment or indebtedness
incurred solely for the purpose of financing the acquisition of such equipment,
or (ii) existing on such equipment at the time of its acquisition or (iii) any
extensions, refinancings and renewals of items (i) and (ii), provided that (1)
the lien is confined solely to the property so acquired and improvements
thereon, and (2) such Indebtedness does not exceed the lesser of the cost or
fair market value of the equipment financed with such Indebtedness;

                      (d)    Subordinated Debt;

                      (e) Indebtedness to trade creditors incurred in the
ordinary course of Borrower's or a Subsidiary's business;

                      (f) Extensions, refinancings, modifications, amendments
and restatements of any items of Permitted Indebtedness, provided that the
principal amount thereof is not increased or the terms thereof are not modified
to impose more burdensome terms upon Borrower or its Subsidiary, as the case may
be, and provided that such extension, refinancing, modification, amendment or
restatement is permitted by any applicable subordination agreement;

                      (g) Capital leases entered into in the ordinary course of
Borrower's or a Subsidiary's business;

                      (h) Indebtedness incurred as a result of the endorsement
of negotiable instruments for deposit or collection or similar transactions in
the ordinary course of business;

                      (i) Contingent Obligations of Borrower consisting of
guarantees (and other credit support) of the obligations of vendors and
suppliers of Borrower in respect of transactions entered into the in ordinary
course of business, provided that such guarantees (and other credit support)
shall not at any time exceed $100,000 in the aggregate; and

                      (j) Indebtedness of a Subsidiary to Borrower incurred in
the ordinary course of business.

                      "Permitted Investment" means:

                      (a) Investments existing on the Closing Date disclosed in
the Schedule;

                      (b) (i) marketable direct obligations issued or
unconditionally guaranteed by the United States of America or any agency or any
State thereof maturing within one (1) year from the date of acquisition thereof,
(ii) commercial paper maturing no more than one (1) year from the date of
creation thereof and currently having rating of at least A-2 or P-2 from either
Standard & Poor's Corporation or Moody's Investors Service, (iii) certificates
of deposit maturing no more than one (1) year from the date of investment
therein issued by Bank and (iv) Bank's money market accounts;

                                       4
<PAGE>

                      (c) Repurchases of stock from former employees or
directors of Borrower under the terms of applicable repurchase agreement
approved by Borrower's Board of Directors;

                      (d) Investments consisting of the endorsement of
negotiable instruments for deposit or collection or similar transactions in the
ordinary course of business;

                      (e) Investments not to exceed $200,000 in the aggregate in
any fiscal year consisting of (i) travel advances and employee relocation loans
and other employee loans and advances in the ordinary course of business, and
(ii) loans to employees, officers or directors relating to the purchase of
equity securities of Borrower or its Subsidiaries pursuant to employee stock
purchase plan agreements approved by Borrower's Board of Directors;

                      (f) Investments (whether consisting of the purchase of
securities, loans, capital contributions or otherwise) by Borrower in
Subsidiaries made in the ordinary course of business (provided that in no event,
notwithstanding anything to the contrary in this Agreement, shall Borrower
transfer any Collateral to a Subsidiary);

                      (g) Investments consisting of notes receivable or, prepaid
royalties and other credit extensions to customers and suppliers who are not
Affiliates, in the ordinary course of business;

                      (h) Investments in joint ventures or strategic alliances
in the ordinary course of Borrower's business;

                      (i) Investments not otherwise permitted under Section 7.7
which do not exceed $100,000 in the aggregate during the term of this Agreement;
and

                      (j) Investments permitted by Borrower's investment policy,
as amended from time to time, provided that such investment policy (and any such
amendment thereto) has been approved by Bank.

                      "Permitted Liens" means the following:

                      (a) Any Liens existing on the Closing Date and disclosed
in the Schedule or arising under this Agreement or the other Loan Documents;

                      (b) Liens for taxes, fees, assessments or other
governmental charges or levies, either not delinquent or being contested in good
faith by appropriate proceedings, provided the same have no priority over any of
Bank's security interests;

                      (c) Liens of materialmen, mechanics, warehousemen,
carriers, artisan's or other similar Liens arising in the ordinary course of
Borrower's business or by operation of law, which are not past due or which are
being contested in good faith by appropriate proceedings and for which reserves
have been established in accordance with GAAP; and

                      (d) Leases, subleases, licenses and sublicenses granted to
others in the ordinary course of business not interfering in any material
respect in the conduct of the business of Borrower, and any interest or title of
a lessor, sublessor, licensor or sublicensor or under any lease, sublease,
license or sublicense.

                      "Person" means any individual, sole proprietorship,
partnership, limited liability company, joint venture, trust, unincorporated
organization, association, corporation, institution, public benefit corporation,
firm, joint stock company, estate, entity or governmental agency.

                      "Prime Rate" means the variable rate of interest, per
annum, most recently announced by Bank, as its "prime rate," whether or not such
announced rate is the lowest rate available from Bank.

                                       5
<PAGE>

                      "Responsible Officer" means each of the Chief Executive
Officer, the Chief Operating Officer, the Chief Financial Officer and the
Controller of Borrower.

                      "Schedule" means the schedule of exceptions attached
hereto and approved by Bank, if any.

                      "Subordinated Debt" means any debt incurred by Borrower
that is subordinated to the debt owing by Borrower to Bank on terms acceptable
to Bank (and identified as being such by Borrower and Bank).

                      "Subsidiary" means any corporation, company or partnership
in which (i) any general partnership interest or (ii) more than 50% of the stock
or other units of ownership which by the terms thereof has the ordinary voting
power to elect the Board of Directors, managers or trustees of the entity, at
the time as of which any determination is being made, is owned by Borrower,
either directly or through an Affiliate.

                      "Trademarks" means any trademark and servicemark rights,
whether registered or not, applications to register and registrations of the
same and like protections, and the entire goodwill of the business of Borrower
connected with and symbolized by such trademarks.

               1.2 Accounting Terms. All accounting terms not specifically
defined herein shall be construed in accordance with GAAP and all calculations
made hereunder shall be made in accordance with GAAP. When used herein, the
terms "financial statements" shall include the notes and schedules thereto.

        2. LOAN AND TERMS OF PAYMENT.

               2.1 Credit Extensions.

                      Borrower promises to pay to the order of Bank, in lawful
money of the United States of America, the aggregate unpaid principal amount of
all Credit Extensions made by Bank to Borrower hereunder. Borrower shall also
pay interest on the unpaid principal amount of such Credit Extensions at rates
in accordance with the terms hereof.

                      (a) Equipment Advances.

                             (i) Subject to and upon the terms and conditions of
this Agreement, at any time from the date hereof through October 23, 2003, Bank
agrees to make advances (each an "Equipment Advance" and, collectively, the
"Equipment Advances") to Borrower in an aggregate amount not to exceed Equipment
Line. Each Equipment Advance shall not exceed one hundred percent (100%) of the
invoice amount of the Equipment reasonably approved by Bank from time to time
(which Borrower shall, in any case, have purchased within 90 days of the date of
the corresponding Equipment Advance). Notwithstanding anything to the contrary
contained herein, (i) the aggregate amount of all Equipment Advances used for
the purchase of computer equipment shall not exceed Three Hundred Thousand
Dollars ($300,000) during the term of this Agreement, and (ii) the aggregate
amount of all Equipment Advances used to finance sales tax and installations
costs shall not exceed Two Hundred Thousand Dollars ($200,000) during the term
of this Agreement. On the Closing Date, Bank will finance an initial Equipment
Advance for Equipment purchased up to five hundred seventy four (574) days prior
to the Closing Date provided that Borrower provides Bank with copies of invoices
for such equipment purchases on or prior to the Closing Date.

                             (ii) Interest shall accrue on the initial Equipment
Advance from the Closing Date at the rate specified in Section 2.2, and shall be
payable monthly on the twenty third (23rd) day of each month so long as any
Equipment Advances are outstanding. The initial Equipment Advance shall be
payable in twenty-four (24) equal monthly installments of principal, plus all
accrued interest, beginning on twenty third (23rd) day of the month immediately
following the Closing Date, and continuing on the same day of each month
thereafter through the Equipment Maturity Date, at which time all amounts owing
under this Section 2.1(a) shall be immediately due and payable. The initial
Equipment Advances, once repaid, may not be reborrowed. Borrower may prepay the
initial Equipment Advances without penalty or premium

                                       6
<PAGE>

                             (iii) Interest shall accrue from the date of each
Equipment Advance at the rate specified in Section 2.2, and shall be payable
monthly on the twenty third (23rd) day of each month so long as any Equipment
Advances are outstanding. Any Equipment Advances that are outstanding on April
24, 2003, which were not part of the initial Equipment Advance, shall be payable
in thirty (30) equal monthly installments of principal, plus all accrued
interest, beginning on May 23, 2003, and continuing on the same day of each
month thereafter through the Equipment Maturity Date. Any Equipment Advances
that are outstanding on October 24, 2003, which were not part of the initial
Equipment Advance and which were not outstanding on April 24, 2003, shall be
payable in twenty-four (24) equal monthly installments of principal, plus all
accrued interest, beginning on November 23, 2003, and continuing on the same day
of each month thereafter through the Equipment Maturity Date, at which time all
amounts owing under this Section 2.1(a) and any other amounts owing under this
Agreement shall be immediately due and payable. Equipment Advances, once repaid,
may not be reborrowed. Borrower may prepay any Equipment Advances without
penalty or premium.

                             (iv) When Borrower desires to obtain an Equipment
Advance, Borrower shall notify Bank (which notice shall be irrevocable) by
facsimile transmission to be received no later than 3:00 p.m. Pacific time three
(3) Business Days before the day on which the Equipment Advance is to be made.
Such notice shall be substantially in the form of Exhibit B. The notice shall be
signed by a Responsible Officer or its designee and include a copy of the
invoice for any Equipment to be financed.

               2.2 Interest Rates, Payments, and Calculations.

                      (a) Interest Rate - Equipment Advances. Except as set
forth in Section 2.2(b), the Equipment Advances shall bear interest, on the
outstanding Daily Balance thereof, at a rate equal to three percent (3.0%) above
the Prime Rate.

                      (b) Late Fee; Default Rate. If any payment is not made
within ten (10) days after the date such payment is due, Borrower shall pay Bank
a late fee equal to the lesser of (i) five percent (5%) of the amount of such
unpaid amount or (ii) the maximum amount permitted to be charged under
applicable law. All Obligations shall bear interest, upon the occurrence and
during the continuance of an Event of Default, at a rate equal to five (5)
percentage points above the interest rate applicable immediately prior to the
occurrence of the Event of Default.

                      (c) Payments. Interest hereunder shall be due and payable
on the twenty third (23rd) calendar day of each month during the term hereof.
Bank shall, at its option, and with written notice to Borrower in the ordinary
course of business charge such interest, all Bank Expenses, and all Periodic
Payments against any of Borrower's deposit accounts maintained with the Bank or
against the Equipment Line, in which case those amounts shall thereafter accrue
interest at the rate then applicable hereunder. Any interest not paid when due
shall be compounded by becoming a part of the Obligations, and such interest
shall thereafter accrue interest at the rate then applicable hereunder. All
payments shall be free and clear of any taxes, withholdings, duties, impositions
or other charges, to the end that Bank will receive the entire amount of any
Obligations payable hereunder, regardless of source of payment.

                      (d) Computation. In the event the Prime Rate is changed
from time to time hereafter, the applicable rate of interest hereunder shall be
increased or decreased, effective as of the day the Prime Rate is changed, by an
amount equal to such change in the Prime Rate. All interest chargeable under the
Loan Documents shall be computed on the basis of a three hundred sixty (360) day
year for the actual number of days elapsed.

               2.3 Crediting Payments. Except when an Event of Default has
occurred and is continuing, Bank shall credit a wire transfer of funds, check or
other item of payment to such deposit account or Obligation as Borrower
specifies. When an Event of Default occurs and is continuing, the receipt by
Bank of any wire transfer of funds, check, or other item of payment shall be
immediately applied to conditionally reduce Obligations, but shall not be
considered a payment on account unless such payment is of immediately available
federal funds or unless and until such check or other item of payment is honored
when presented for payment. Notwithstanding anything to the

                                       7
<PAGE>

contrary contained herein, any wire transfer or payment received by Bank after
12:00 noon Pacific time shall be deemed to have been received by Bank as of the
opening of business on the immediately following Business Day. Whenever any
payment to Bank under the Loan Documents would otherwise be due (except by
reason of acceleration) on a date that is not a Business Day, such payment shall
instead be due on the next Business Day, and additional fees or interest, as the
case may be, shall accrue and be payable for the period of such extension.

               2.4 Fees. Borrower shall pay to Bank the following:

                      (a) Facility Fee. On the Closing Date, a Facility Fee
equal to Ten Thousand Dollars ($10,000), which shall be nonrefundable; and

                      (b) Bank Expenses. On the Closing Date, all Bank Expenses
incurred through the Closing Date, including reasonable attorneys' fees and
expenses and, after the Closing Date, all Bank Expenses, including reasonable
attorneys' fees and expenses, as and when they become due.

               2.5 Additional Costs. In case any change after the date hereof in
any law, regulation, treaty or official directive or the interpretation or
application thereof by any court or any governmental authority charged with the
administration thereof or the compliance with any guideline or request of any
central bank or other governmental authority (whether or not having the force of
law):

                      (a) subjects Bank to any tax with respect to payments of
principal or interest or any other amounts payable hereunder by Borrower or
otherwise with respect to the transactions contemplated hereby (except for taxes
on the overall net income of Bank imposed by the United States of America or any
political subdivision thereof);

                      (b) imposes, modifies or deems applicable any deposit
insurance, reserve, special deposit or similar requirement against assets held
by, or deposits in or for the account of, or loans by, Bank; or

                      (c) imposes upon Bank any other condition with respect to
its performance under this Agreement,

and the result of any of the foregoing is to increase the cost to Bank, reduce
the income receivable by Bank or impose any expense upon Bank with respect to
the Obligations, Bank shall notify Borrower thereof. Borrower agrees to pay to
Bank the amount of such increase in cost, reduction in income or additional
expense as and when such cost, reduction or expense is incurred or determined,
upon presentation by Bank of a statement of the amount and setting forth Bank's
calculation thereof, all in reasonable detail, which statement shall be deemed
true and correct absent manifest error.

               2.6 Term. This Agreement shall become effective on the Closing
Date and, subject to Section 12.7, shall continue in full force and effect for
so long as any Obligations remain outstanding or Bank has any obligation to make
Credit Extensions under this Agreement. Notwithstanding the foregoing, Bank
shall have the right to terminate its obligation to make Credit Extensions under
this Agreement immediately and without notice upon the occurrence and during the
continuance of an Event of Default. Notwithstanding termination, Bank's Lien on
the Collateral shall remain in effect for so long as any Obligations are
outstanding.

        3. CONDITIONS OF LOANS.

               3.1 Conditions Precedent to Initial Credit Extension. The
obligation of Bank to make the initial Credit Extension is subject to the
condition precedent that Bank shall have received, in form and substance
satisfactory to Bank, the following:

                      (a) this Agreement;

                                       8
<PAGE>

                      (b) a certificate of the Secretary of Borrower with
respect to incumbency and resolutions authorizing the execution and delivery of
this Agreement;

                      (c) a UCC financing statement (DE);

                      (d)    agreement to provide insurance;

                      (e) payment of the fees and Bank Expenses then due
specified in Section 2.4 hereof;

                      (f) current financial statements of Borrower; and

                      (g) such other documents, and completion of such other
matters, as Bank may reasonably deem necessary or appropriate.

               3.2 Conditions Precedent to all Credit Extensions. The obligation
of Bank to make each Credit Extension, including the initial Credit Extension,
is further subject to the following conditions:

                      (a) timely receipt by Bank of the Payment/Advance Form as
provided in Section 2.1; and

                      (b) the representations and warranties contained in
Section 5 shall be true and correct in all material respects on and as of the
date of such Payment/Advance Form and on the effective date of each Credit
Extension as though made at and as of each such date, and no Event of Default
shall have occurred and be continuing, or would exist after giving effect to
such Credit Extension (provided, however, that those representations and
warranties expressly referring to another date shall be true, correct and
complete in all material respects as of such date). The making of each Credit
Extension shall be deemed to be a representation and warranty by Borrower on the
date of such Credit Extension as to the accuracy of the facts referred to in
this Section 3.2.

        4. CREATION OF SECURITY INTEREST.

               4.1 Grant of Security Interest. Borrower grants and pledges to
Bank a continuing security interest in all presently existing and hereafter
acquired or arising Collateral in order to secure prompt repayment of any and
all Obligations and in order to secure prompt performance by Borrower of each of
its covenants and duties under the Loan Documents. Subject to Permitted Liens,
upon the due filing of appropriately completed financing statements with the
applicable governing filing offices, such security interest constitutes a valid,
first priority security interest in the presently existing Collateral, and will
constitute a valid, first priority security interest in Collateral acquired
after the date hereof.

               4.2 Termination of Security Interest. Upon the payment in full of
all amounts due under this Agreement and of all other Obligations and upon
termination of Bank's obligation to make Credit Extensions to Borrower, Bank
shall, at the cost and expense of Borrower, execute and deliver to Borrower all
such documents and instruments that shall be necessary to evidence termination
of this Agreement and the security interests created hereunder.

               4.3 Delivery of Additional Documentation Required. Borrower shall
from time to time execute and deliver to Bank, at the reasonable request of
Bank, all Negotiable Collateral, all financing statements and other documents
that Bank may reasonably request, in form satisfactory to Bank, to perfect and
continue the perfection of Bank's security interests in the Collateral and in
order to fully consummate all of the transactions contemplated under the Loan
Documents.

               4.4 Right to Inspect. Bank (through any of its officers,
employees, or agents) shall have the right, upon reasonable prior notice, from
time to time during Borrower's usual business hours but no more than twice a
year (unless an Event of Default has occurred and is continuing), to inspect
Borrower's Books and to make

                                       9
<PAGE>

copies thereof and to check, test, and appraise the Collateral in order to
verify Borrower's financial condition or the amount, condition of, or any other
matter relating to, the Collateral.

        5. REPRESENTATIONS AND WARRANTIES.

               Borrower represents and warrants as follows:

               5.1 Due Organization and Qualification. Borrower and each
Subsidiary is a corporation duly existing under the laws of its state of
incorporation and qualified and licensed to do business in any state in which
the conduct of its business or its ownership of property requires that it be so
qualified, except where the failure to do so would not reasonably be expected to
have a Material Adverse Effect.

               5.2 Due Authorization; No Conflict. The execution, delivery, and
performance of the Loan Documents are within Borrower's powers, have been duly
authorized, and are not in conflict with nor constitute a breach of any
provision contained in Borrower's Certificate of Incorporation or Bylaws, nor
will they constitute an event of default under any material agreement to which
Borrower is a party or by which Borrower is bound. Borrower is not in default
under any material agreement to which it is a party or by which it is bound.

               5.3 No Prior Encumbrances. Borrower has good and marketable title
to the Collateral, free and clear of Liens, except for Permitted Liens.

               5.4 Bona Fide Accounts. To the best of Borrower's knowledge, all
Accounts are bona fide existing obligations. Borrower has not received notice of
actual or imminent Insolvency Proceedings of any material account debtor.

               5.5 Merchantable Inventory. To the best of Borrower's knowledge,
all Inventory is in all material respects of good and marketable quality, free
from all material defects, except for Inventory for which adequate reserves have
been made.

               5.6 Intellectual Property. To the best of Borrower's knowledge,
Borrower is the sole owner of the Intellectual Property, except for licenses
granted by Borrower to its customers in the ordinary course of business. To the
best of Borrower's knowledge, each of the Patents is valid and enforceable, and
no part of the Intellectual Property has been judged invalid or unenforceable,
in whole or in part, and no claim has been made that any part of the
Intellectual Property violates the rights of any third party.

               5.7 Name; Location of Chief Executive Office. Except as disclosed
in the Schedule, Borrower has not done business under any name other than that
specified on the signature page hereof. The chief executive office of Borrower
is located at the address indicated in Section 10 hereof. All the Collateral is
located only at the location set forth in Section 10 hereof.

               5.8 Litigation. Except as set forth in the Schedule, there are no
actions or proceedings pending by or against Borrower or any Subsidiary before
any court or administrative agency in which an adverse decision would reasonably
be expected to have a Material Adverse Effect, or a material adverse effect on
Borrower's interest or Bank's security interest in the Collateral.

               5.9 No Material Adverse Change in Financial Statements. All
consolidated and consolidating financial statements related to Borrower and any
Subsidiary that Bank has received from Borrower fairly present in all material
respects Borrower's financial condition as of the date thereof and Borrower's
consolidated and consolidating results of operations for the period then ended.
There has not been a material adverse change in the consolidated or the
consolidating financial condition of Borrower since the date of the most recent
of such financial statements submitted to Bank.

               5.10 Solvency, Payment of Debts. Borrower is solvent and able to
pay its debts (including trade debts) as they mature.

                                       10
<PAGE>

               5.11 Regulatory Compliance. Borrower and each Subsidiary have met
the minimum funding requirements of ERISA with respect to any employee benefit
plans subject to ERISA, and no event has occurred resulting from Borrower's
failure to comply with ERISA that could result in Borrower's incurring any
material liability. Borrower is not an "investment company" or a company
"controlled" by an "investment company" within the meaning of the Investment
Company Act of 1940. Borrower is not engaged principally, or as one of the
important activities, in the business of extending credit for the purpose of
purchasing or carrying margin stock (within the meaning of Regulations T and U
of the Board of Governors of the Federal Reserve System). Borrower has complied
with all the provisions of the Federal Fair Labor Standards Act. Borrower has
not violated any statutes, laws, ordinances or rules applicable to it, violation
of which would reasonably be expected to have a Material Adverse Effect.

               5.12 Environmental Condition. Except as disclosed in the
Schedule, none of Borrower's or any Subsidiary's properties or assets has ever
been used by Borrower or any Subsidiary or, to the best of Borrower's knowledge,
by previous owners or operators, in the disposal of, or to produce, store,
handle, treat, release, or transport, any hazardous waste or hazardous substance
other than in accordance with applicable law or where any such noncompliance
would not reasonably be expected to have a Material Adverse Effect; to the best
of Borrower's knowledge, none of Borrower's properties or assets has ever been
designated or identified in any manner pursuant to any environmental protection
statute as a hazardous waste or hazardous substance disposal site, or a
candidate for closure pursuant to any environmental protection statute; no lien
arising under any environmental protection statute has attached to any revenues
or to any real or personal property owned by Borrower or any Subsidiary; and
neither Borrower nor any Subsidiary has received a summons, citation, notice, or
directive from the Environmental Protection Agency or any other federal, state
or other governmental agency concerning any action or omission by Borrower or
any Subsidiary resulting in the releasing, or otherwise disposing of hazardous
waste or hazardous substances into the environment.

               5.13 Taxes. Borrower and each Subsidiary have filed or caused to
be filed all material tax returns required to be filed, and have paid, or have
made adequate provision for the payment of, all taxes reflected therein except
those being contested in good faith with adequate reserves under GAAP.

               5.14 Subsidiaries. Borrower does not own any stock, partnership
interest or other equity securities of any Person, except for Permitted
Investments.

               5.15 Government Consents. Borrower and each Subsidiary have
obtained all consents, approvals and authorizations of, made all declarations or
filings with, and given all notices to, all governmental authorities that are
necessary for the continued operation of Borrower's business as currently
conducted, the failure to obtain which would reasonably be expected to have a
Material Adverse Effect.

               5.16 Full Disclosure. No representation, warranty or other
statement made by Borrower in any certificate or written statement furnished to
Bank under the circumstances when made contains any untrue statement of a
material fact or omits to state a material fact necessary in order to make the
statements contained in such certificates or statements not misleading. Bank
recognizes that the projections and forecasts provided by Borrower in good faith
and based upon reasonable assumptions are not to be viewed as facts and that
actual results during the period or periods covered by any such projections and
forecasts may differ from the projected or forecasted results.

        6. AFFIRMATIVE COVENANTS.

               Borrower covenants and agrees that, until payment in full of all
outstanding Obligations, and for so long as Bank may have any commitment to make
a Credit Extension hereunder, Borrower shall do all of the following:

               6.1 Good Standing. Borrower shall maintain its and each of its
Subsidiaries' corporate existence and good standing in its jurisdiction of
incorporation and maintain qualification in each jurisdiction in which it is
required under applicable law except where the failure to do so would not
reasonably be expected to

                                       11
<PAGE>

cause a Material Adverse Effect. Borrower shall maintain, and shall cause each
of its Subsidiaries to maintain, in force all licenses, approvals and
agreements, the loss of which would reasonably be expected to have a Material
Adverse Effect.

               6.2 Government Compliance. Borrower shall meet, and shall cause
each Subsidiary to meet, the minimum funding requirements of ERISA with respect
to any employee benefit plans subject to ERISA. Borrower shall comply, and shall
cause each Subsidiary to comply, with all statutes, laws, ordinances and
government rules and regulations to which it is subject, noncompliance with
which could have a Material Adverse Effect.

               6.3 Financial Statements, Reports, Certificates. Borrower shall
deliver the following to Bank: (a) as soon as available, but in any event within
thirty (30) days after the end of each calendar month, a company prepared
consolidated balance sheet, income, and cash flow statement covering Borrower's
consolidated operations during such period, prepared in accordance with GAAP
(absent footnotes and subject to year-end adjustments), consistently applied, in
a form reasonably acceptable to Bank and certified by a Responsible Officer; (b)
within five (5) days after the filing of Borrower's Form 10-K with the
Securities and Exchange Commission at the end of Borrower's fiscal year, audited
consolidated financial statements of Borrower prepared in accordance with GAAP,
consistently applied, together with an unqualified opinion on such financial
statements of an independent certified public accounting firm reasonably
acceptable to Bank; (c) if applicable, copies of all statements, reports and
notices sent or made available generally by Borrower to its security holders or
to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed
with the Securities and Exchange Commission within five (5) days of relevant
filing with Securities and Exchange Commission; (d) promptly upon receipt of
notice thereof, a report of any legal actions pending or threatened against
Borrower or any Subsidiary that would reasonably be expected to result in
damages or costs to Borrower or any Subsidiary of Fifty Thousand Dollars
($50,000) or more; and (e) such budgets, sales projections, operating plans or
other financial information as Bank may reasonably request from time to time
generally prepared by Borrower in the ordinary course of business.

        Borrower shall deliver to Bank with the monthly financial statements a
Compliance Certificate signed by a Responsible Officer in substantially the form
of Exhibit C hereto.

               6.4 [Intentionally Omitted.]

               6.5 Taxes. Borrower shall make, and shall cause each Subsidiary
to make, due and timely payment or deposit of all material federal, state, and
local taxes, assessments, or contributions required of it by law, and will
execute and deliver to Bank, on demand, appropriate certificates attesting to
the payment or deposit thereof; and Borrower will make, and will cause each
Subsidiary to make, timely payment or deposit of all material tax payments and
withholding taxes required of it by applicable laws, including, but not limited
to, those laws concerning F.I.C.A., F.U.T.A., state disability, and local,
state, and federal income taxes, and will, upon request, furnish Bank with proof
reasonably satisfactory to Bank indicating that Borrower or a Subsidiary has
made such payments or deposits; provided that Borrower or a Subsidiary need not
make any payment if the amount or validity of such payment is contested in good
faith by appropriate proceedings and is reserved against (to the extent required
by GAAP) by Borrower.

               6.6 Insurance.

                      (a) Borrower, at its expense, shall keep the Collateral
insured against loss or damage by fire, theft, explosion, sprinklers, and other
hazards and risks, and in such amounts, as ordinarily insured against by other
owners in similar businesses conducted in the locations where Borrower's
business is conducted on the date hereof. Borrower shall also maintain insurance
relating to Borrower's business, ownership and use of the Collateral in amounts
and of a type that are customary to businesses similar to Borrower's.

                      (b) All such policies of insurance shall be in such form,
with such companies, and in such amounts as are reasonably satisfactory to Bank.
All such policies of property insurance shall contain a lender's loss payable
endorsement, in a form satisfactory to Bank, showing Bank as an additional loss
payee thereof, and all

                                       12
<PAGE>

commercial general liability insurance policies shall show the Bank as an
additional insured and shall specify that the insurer must give at least twenty
(20) days notice to Bank before canceling its policy for any reason. Upon Bank's
request, Borrower shall deliver to Bank certified copies of such policies of
insurance and evidence of the payments of all premiums therefore. All proceeds
payable under any such policy shall, at the option of Bank, be payable to Bank
to be applied on account of the Obligations.

               6.7 Accounts. Borrower shall maintain depository and operating
accounts with Bank.

               6.8 Liquidity. Borrower shall maintain at all times, measured as
of the last day of each month, a balance of unrestricted cash which is greater
than Borrower's Cash Burn, provided, however, this Section 6.8 shall be
automatically deleted if Borrower provides Bank with evidence of Borrower's
positive cash flow for six (6) consecutive monthly reporting periods. As used
herein, "Cash Burn" shall mean the net change in Borrower's cash during the four
months immediately preceding the date of measurement net of changes in debt,
stock, paid-in capital and minority interests.

               6.9 Minimum Cash Balance. Borrower shall maintain at all times,
measured as of the last day of each month, a minimum balance of unrestricted
cash and cash equivalents at Bank of at least Five Million Dollars ($5,000,000).

               6.10 Protection of Intellectual Property Rights. Borrower shall
use commercially reasonable efforts to (i) protect, defend and maintain the
validity and enforceability of the material Trademarks, Patents and Copyrights
and (ii) detect infringements of the material Trademarks, Patents and Copyrights
and promptly advise Bank in writing of material infringements detected.

               6.11 Equipment Location. All Equipment financed by Bank, must
have asset tags in form and substance acceptable to Bank, and shall remain
located in the state of California at the address set forth in Section 10 of
this Agreement.

               6.12 Right of First Refusal. Borrower shall offer Bank a right of
first refusal for all of Borrower's borrowing transactions, provided that Bank's
terms are equal to or more favorable then other third party's terms.

               6.13 Further Assurances. At any time and from time to time
Borrower shall execute and deliver such further instruments and take such
further action as may reasonably be requested by Bank to effect the purposes of
this Agreement.

        7. NEGATIVE COVENANTS.

               Borrower covenants and agrees that, so long as any credit
hereunder shall be available and until payment in full of the outstanding
Obligations or for so long as Bank may have any commitment to make any Credit
Extensions, Borrower will not do any of the following:

               7.1 Dispositions. Except for the sale of, merger or consolidation
of Lynx GmbH with or into any other Person and the merger of
Beteiligungsgesellschaft mbH into Axaron, convey, sell, lease, transfer or
otherwise dispose of (collectively, a "Transfer"), or permit any of its
Subsidiaries to Transfer, all or substantially all of its business or property,
provided that in no event and notwithstanding anything to the contrary in this
Agreement shall Borrower Transfer all or any portion of the Collateral.

               7.2 Change in Business or Executive Office. Engage in any
business, or permit any of its Subsidiaries to engage in any business, other
than the businesses currently engaged in by Borrower and any business
substantially similar, related or ancillary thereto (or incidental thereto); or
cease to conduct business in the manner conducted by Borrower as of the Closing
Date (other than the merger of Beteiligungsgesellschaft mbH into Axaron or the
sale of, merger or consolidation of Lynx GmbH with or into any other Person); or
without ten (10) days prior

                                       13
<PAGE>

written notification to Bank, relocate its chief executive office or state of
incorporation or change its legal name; or without Bank's prior written consent,
change the date on which its fiscal year ends.

               7.3 Mergers or Acquisitions. Without the prior written consent of
Bank, which will not be unreasonably withheld, merge or consolidate, or permit
any of its Subsidiaries to merge or consolidate, with or into any other business
organization (other than mergers or consolidations of a Subsidiary into another
Subsidiary), or acquire, or permit any of its Subsidiaries to acquire, all or
substantially all of the capital stock or property of another Person except (A)
where (i) the Borrower or Subsidiary, as applicable, is the surviving entity and
(ii) no Event of Default has occurred, is continuing or would exist after giving
effect to such transactions, (B) for the merger of Beteiligungsgesellschaft mbH
into Axaron, or (C) the sale of, merger or consolidation of Lynx GmbH with or
into any other Person.

               7.4 Indebtedness. Create, incur, assume or be or remain liable
with respect to any Indebtedness, or permit any Subsidiary to do so, other than
Permitted Indebtedness (and subject to Section 6.12).

               7.5 Encumbrances. Create, incur, assume or suffer to exist any
Lien with respect to (collectively, "Encumber") any of the Collateral, except
for Permitted Liens; or Encumber its Intellectual Property, except in the
ordinary course of Borrower's business.

               7.6 Distributions. Pay any dividends or make any other
distribution or payment on account of or in redemption, retirement or purchase
of any capital stock, or permit any of its Subsidiaries to do so, except that
(i) Borrower may repurchase the stock of former employees, consultants, or
directors pursuant to stock repurchase agreements as long as an Event of Default
does not exist prior to such repurchase or would not exist after giving effect
to such repurchase, and (ii) Borrower may make distributions payable solely in
Borrower's capital stock and may convert any of its convertible securities into
other equity securities pursuant to the terms of such convertible securities or
otherwise in exchange therefor.

               7.7 Investments. Directly or indirectly acquire or own, or make
any Investment in or to any Person, or permit any of its Subsidiaries so to do,
other than Permitted Investments and as permitted by Section 7.3; or suffer or
permit any Subsidiary to be a party to, or be bound by, an agreement that
restricts such Subsidiary from paying dividends or otherwise distributing
property to Borrower.

               7.8 Transactions with Affiliates. Directly or indirectly enter
into or permit to exist any material transaction with any Affiliate of Borrower
except for (a) a merger or consolidation of Beteiligungsgesellschaft mbH into
Axaron or (b) transactions that are in the ordinary course of Borrower's
business, upon fair and reasonable terms that are no less favorable to Borrower
than would be obtained in an arm's length transaction with a non-affiliated
Person.

               7.9 Subordinated Debt. Make any payment in respect of any
Subordinated Debt, or permit any of its Subsidiaries to make any such payment,
except in compliance with the terms of such Subordinated Debt, or amend in a
manner adverse to the Bank any provision contained in any documentation relating
to the Subordinated Debt without Bank's prior written consent.

               7.10 Collateral. Store any Collateral with a bailee,
warehouseman, or other third party unless the third party has been notified of
Bank's security interest and Bank (a) has received an acknowledgment from the
third party that it is holding or will hold the Collateral for Bank's benefit or
(b) is in pledge possession of the warehouse receipt, where negotiable, covering
such Collateral. Store or maintain any Collateral at a location other than the
location set forth in Section 10 of this Agreement.

               7.11 Compliance. Become an "investment company" or be controlled
by an "investment company," within the meaning of the Investment Company Act of
1940, or become principally engaged in, or undertake as one of its important
activities, the business of extending credit for the purpose of purchasing or
carrying margin stock, or use the proceeds of any Credit Extension for such
purpose. Fail to meet the minimum funding requirements of ERISA, permit a
Reportable Event or Prohibited Transaction, as defined in ERISA, to

                                       14
<PAGE>

occur, fail to comply with the Federal Fair Labor Standards Act or violate any
law or regulation, which violation would reasonably be expected to have a
Material Adverse Effect, or a material adverse effect on the Collateral or the
priority of Bank's Lien on the Collateral, or permit any of its Subsidiaries to
do any of the foregoing.

        8. EVENTS OF DEFAULT.

               Any one or more of the following events shall constitute an Event
of Default by Borrower under this Agreement:

               8.1 Payment Default. If Borrower fails to pay, when due, any of
the Obligations;

               8.2 Covenant Default. If Borrower fails to perform any obligation
under Article 6 or violates any of the covenants contained in Article 7 of this
Agreement, or fails or neglects to perform, keep, or observe any other term,
provision, condition, covenant, or agreement contained in this Agreement, in any
of the Loan Documents, or in any other present or future agreement between
Borrower and Bank and as to any default under such other term, provision,
condition, covenant or agreement that can be cured, has failed to cure such
default within fifteen (15) Business Days after Borrower receives notice thereof
or any officer of Borrower becomes aware thereof; provided, however, that if the
default cannot by its nature be cured within the fifteen (15) Business Day
period or cannot after diligent attempts by Borrower be cured within such (15)
Business Day period, and such default is likely to be cured within a reasonable
time, then Borrower shall have an additional reasonable period (which shall not
in any case exceed thirty (30) days) to attempt to cure such default, and within
such reasonable time period the failure to have cured such default shall not be
deemed an Event of Default (provided that no Credit Extensions will be required
to be made during such cure period);

               8.3 Material Adverse Effect. If there occurs any circumstance or
circumstances that would reasonably be expected to have a Material Adverse
Effect;

               8.4 Attachment. If any portion of Borrower's assets is attached,
seized, subjected to a writ or distress warrant, or is levied upon, or comes
into the possession of any trustee, receiver or person acting in a similar
capacity and such attachment, seizure, writ or distress warrant or levy has not
been removed, discharged or rescinded within thirty (30) days, or if Borrower is
enjoined, restrained, or in any way prevented by court order from continuing to
conduct all or any material part of its business affairs, or if a judgment or
other claim becomes a lien or encumbrance upon any material portion of
Borrower's assets, or if a notice of lien, levy, or assessment is filed of
record with respect to any of Borrower's assets by the United States Government,
or any department, agency, or instrumentality thereof, or by any state, county,
municipal, or governmental agency, and the same is not paid within ten (10)
Business Days after Borrower receives notice thereof, provided that none of the
foregoing shall constitute an Event of Default where such action or event is
stayed or an adequate bond has been posted pending a good faith contest by
Borrower (provided that no Credit Extensions will be required to be made during
such cure period);

               8.5 Insolvency. If Borrower becomes insolvent, or if an
Insolvency Proceeding is commenced by Borrower, or if an Insolvency Proceeding
is commenced against Borrower and is not dismissed or stayed within forty-five
(45) days (provided that no Credit Extensions will be made prior to the
dismissal of such Insolvency Proceeding);

               8.6 Other Agreements. If there is a default or other failure to
perform in any agreement to which Borrower is a party or by which it is bound
resulting in a right by a third party or parties, whether or not exercised, to
accelerate the maturity of any Indebtedness in an amount in excess of Two
Hundred Fifty Thousand Dollars ($250,000); or which would reasonably be expected
to have a Material Adverse Effect;

               8.7 Judgments. If a judgment or judgments for the payment of
money in an amount, individually or in the aggregate, of at least Two Hundred
Fifty Thousand Dollars ($250,000) in excess of applicable insurance coverage
(provided that a claim therefore has been tendered to and accepted by the
applicable insurance carrier) shall be rendered against Borrower and shall
remain unsatisfied and unstayed for a period of thirty (30) days (provided that
no Credit Extensions will be made prior to the satisfaction or stay of such
judgment); or

                                       15
<PAGE>

               8.8 Misrepresentations. If, as of the date a representation or
warranty is made, any material misrepresentation or material misstatement exists
now in any warranty or representation set forth herein or in any certificate
delivered to Bank by any Responsible Officer pursuant to this Agreement or to
induce Bank to enter into this Agreement or any other Loan Document.

        9. BANK'S RIGHTS AND REMEDIES.

               9.1 Rights and Remedies. Upon the occurrence and during the
continuance of an Event of Default, Bank may, at its election, without notice of
its election and without demand, do any one or more of the following, all of
which are authorized by Borrower:

                      (a) Declare all Obligations, whether evidenced by this
Agreement, by any of the other Loan Documents, or otherwise, immediately due and
payable (provided that upon the occurrence of an Event of Default described in
Section 8.5, all Obligations shall become immediately due and payable without
any action by Bank);

                      (b) Cease advancing money or extending credit to or for
the benefit of Borrower under this Agreement or under any other agreement
between Borrower and Bank;

                      (c) Make such payments and do such acts as Bank considers
necessary or reasonable to protect its security interest in the Collateral.
Borrower agrees to assemble the Collateral if Bank so requires, and to make the
Collateral available to Bank as Bank may designate. Borrower authorizes Bank to
enter the premises where the Collateral is located, to take and maintain
possession of the Collateral, or any part of it, and to pay, purchase, contest,
or compromise any encumbrance, charge, or lien which in Bank's determination
appears to be prior or superior to its security interest and to pay all expenses
incurred in connection therewith. With respect to any of Borrower's owned
premises, Borrower hereby grants Bank a license to enter into possession of such
premises and to occupy the same, without charge, in order to exercise any of
Bank's rights or remedies provided herein, at law, in equity, or otherwise;

                      (d) Set off and apply to the Obligations any and all (i)
balances and deposits of Borrower held by Bank, or (ii) indebtedness at any time
owing to or for the credit or the account of Borrower held by Bank;

                      (e) Ship, reclaim, recover, store, finish, maintain,
repair, prepare for sale, advertise for sale, and sell (in the manner provided
for herein) the Collateral. Bank is hereby granted a license or other right,
solely pursuant to the provisions of this Section 9.1, to use, without charge,
Borrower's labels, patents, copyrights, rights of use of any name, trade
secrets, trade names, trademarks, service marks, and advertising matter, or any
property of a similar nature, as it pertains to the Collateral, in completing
production of, advertising for sale, and selling any Collateral and, in
connection with Bank's exercise of its rights under this Section 9.1, Borrower's
rights under all licenses and all franchise agreements shall inure to Bank's
benefit;

                      (f) Dispose of the Collateral by way of one or more
contracts or transactions, for cash or on terms, in such manner and at such
places (including Borrower's premises) as Bank determines is commercially
reasonable, and apply any proceeds to the Obligations in whatever manner or
order Bank deems appropriate;

                      (g) Bank may credit bid and purchase at any public sale
any of the Collateral; and

                      (h) Any deficiency that exists after disposition of the
Collateral as provided above will be paid immediately by Borrower.

               9.2 Power of Attorney. Effective only upon the occurrence and
during the continuance of an Event of Default, Borrower hereby irrevocably
appoints Bank (and any of Bank's designated officers, or employees) as
Borrower's true and lawful attorney to: (a) endorse Borrower's name on any
checks or other forms of payment or

                                       16
<PAGE>

security that may come into Bank's possession; (b) dispose of any Collateral;
(c) make, settle, and adjust all claims under and decisions with respect to
Borrower's policies of insurance as to Bank's status as loss payee relating to
the Collateral or affecting Bank's status as additional insured; and (d) to
file, in its sole discretion, one or more financing or continuation statements
and amendments thereto, relative to any of the Collateral; provided Bank may
exercise such power of attorney to sign the name of Borrower on any of the
documents described in Section 4.3 regardless of whether an Event of Default has
occurred. The appointment of Bank as Borrower's attorney in fact, and each and
every one of Bank's rights and powers, being coupled with an interest, is
irrevocable until all of the Obligations have been fully repaid and performed
and Bank's obligation to provide Credit Extensions hereunder is terminated.

               9.3 Bank Expenses. If Borrower fails to pay any amounts or
furnish any required proof of payment due to third persons or entities, as
required under the terms of this Agreement, then Bank may do any or all of the
following after reasonable notice to Borrower: (a) make payment of the same or
any part thereof; (b) set up such reserves under a loan facility in Section 2.1
as Bank deems necessary to protect Bank from the exposure created by such
failure; or (c) obtain and maintain insurance policies of the type discussed in
Section 6.6 of this Agreement, and take any action with respect to such policies
as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute
Bank Expenses, shall be immediately due and payable, and shall bear interest at
the then applicable rate hereinabove provided, and shall be secured by the
Collateral. Any payments made by Bank shall not constitute an agreement by Bank
to make similar payments in the future or a waiver by Bank of any Event of
Default under this Agreement.

               9.4 Bank's Liability for Collateral. So long as Bank complies
with reasonable banking practices consistent with Section 9207 of the Code, Bank
shall not in any way or manner be liable or responsible for: (a) the safekeeping
of the Collateral; (b) any loss or damage thereto occurring or arising in any
manner or fashion from any cause; (c) any diminution in the value thereof; or
(d) any act or default of any carrier, warehouseman, bailee, forwarding agency,
or other person whomsoever. All risk of loss, damage or destruction of the
Collateral shall be borne by Borrower.

               9.5 Remedies Cumulative. Bank's rights and remedies under this
Agreement, the Loan Documents, and all other agreements shall be cumulative.
Bank shall have all other rights and remedies not inconsistent herewith as
provided under the Code, by law, or in equity. No exercise by Bank of one right
or remedy shall be deemed an election, and no waiver by Bank of any Event of
Default on Borrower's part shall be deemed a continuing waiver. No delay by Bank
shall constitute a waiver, election, or acquiescence by it. No waiver by Bank
shall be effective unless made in a written document signed on behalf of Bank
and then shall be effective only in the specific instance and for the specific
purpose for which it was given.

               9.6 Demand; Protest. Borrower waives demand, protest, notice of
protest, notice of default or dishonor, notice of payment and nonpayment, notice
of any default, nonpayment at maturity, release, compromise, settlement,
extension, or renewal of accounts, documents, instruments, chattel paper, and
guarantees at any time held by Bank on which Borrower may in any way be liable.

        10. NOTICES.

               Unless otherwise provided in this Agreement, all notices or
demands by any party relating to this Agreement or any other agreement entered
into in connection herewith shall be in writing and (except for financial
statements and other informational documents which may be sent by first-class
mail, postage prepaid) shall be personally delivered or sent by a recognized
overnight delivery service, certified mail, postage prepaid, return receipt
requested, or by telefacsimile to Borrower or to Bank, as the case may be, at
its addresses set forth below:

      If to Borrower:           Lynx Therapeutics, Inc.
                                25861 Industrial Boulevard
                                Hayward, CA 94545
                                Attn: Edward C. Albini, Chief Financial Officer
                                FAX:  (510) 670-9303

                                       17
<PAGE>

      If to Bank:               Comerica Bank-California
                                333 W. Santa Clara St.
                                San Jose, CA 95113
                                Attn:  Corporate Banking Center

      with a copy to:           Comerica Bank-California
                                5 Palo Alto Square, Suite 800
                                3000 El Camino Real
                                Attn:  Jonathan Norris
                                FAX:  (650) 213-1710

        The parties hereto may change the address at which they are to receive
notices hereunder, by notice in writing in the foregoing manner given to the
other.

        11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

               This Agreement shall be governed by, and construed in accordance
with, the internal laws of the State of California, without regard to principles
of conflicts of law. Each of Borrower and Bank hereby submits to the exclusive
jurisdiction of the state and Federal courts located in the County of Santa
Clara, State of California. BORROWER AND BANK EACH HEREBY WAIVE THEIR RESPECTIVE
RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT
OF ANY OF THE LOAN DOCUMENTS OR ANY OF THE TRANSACTIONS CONTEMPLATED THEREIN,
INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER
COMMON LAW OR STATUTORY CLAIMS. EACH PARTY RECOGNIZES AND AGREES THAT THE
FOREGOING WAIVER CONSTITUTES A MATERIAL INDUCEMENT FOR IT TO ENTER INTO THIS
AGREEMENT. EACH PARTY REPRESENTS AND WARRANTS THAT IT HAS REVIEWED THIS WAIVER
WITH ITS LEGAL COUNSEL AND THAT IT KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY
TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL.

        12. GENERAL PROVISIONS.

               12.1 Successors and Assigns. This Agreement shall bind and inure
to the benefit of the respective successors and permitted assigns of each of the
parties; provided, however, that neither this Agreement nor any rights hereunder
may be assigned by Borrower without Bank's prior written consent, which consent
may be granted or withheld in Bank's sole discretion. Bank shall have the right
without the consent of or notice to Borrower to sell, transfer, negotiate, or
grant participation in all or any part of, or any interest in, Bank's
obligations, rights and benefits hereunder.

               12.2 Indemnification. Borrower shall defend, indemnify and hold
harmless Bank and its officers, employees, and agents against: (a) all
obligations, demands, claims, and liabilities claimed or asserted by any other
party in connection with the transactions contemplated by this Agreement; and
(b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank
as a result of or in any way arising out of, following, or consequential to
transactions between Bank and Borrower whether under this Agreement, or
otherwise (including without limitation reasonable attorneys' fees and
expenses), except for losses caused by Bank's gross negligence or willful
misconduct.

               12.3 Time of Essence. Time is of the essence for the performance
of all obligations set forth in this Agreement.

               12.4 Severability of Provisions. Each provision of this Agreement
shall be severable from every other provision of this Agreement for the purpose
of determining the legal enforceability of any specific provision.

                                       18
<PAGE>

               12.5 Amendments in Writing, Integration. Neither this Agreement
nor the Loan Documents can be amended or terminated orally. All prior
agreements, understandings, representations, warranties, and negotiations
between the parties hereto with respect to the subject matter of this Agreement
and the Loan Documents, if any, are merged into this Agreement and the Loan
Documents.

               12.6 Counterparts. This Agreement may be executed in any number
of counterparts and by different parties on separate counterparts, each of
which, when executed and delivered, shall be deemed to be an original, and all
of which, when taken together, shall constitute but one and the same Agreement.

               12.7 Survival. All covenants, representations and warranties made
in this Agreement shall continue in full force and effect so long as any
Obligations remain outstanding or Bank has any obligation to make Credit
Extensions to Borrower. The obligations of Borrower to indemnify Bank with
respect to the expenses, damages, losses, costs and liabilities described in
Section 12.2 shall survive until all applicable statute of limitations periods
with respect to actions that may be brought against Bank have run.

               12.8 Confidentiality. In handling any confidential information
Bank and all employees and agents of Bank, including but not limited to
accountants, shall exercise the same degree of care that it exercises with
respect to its own proprietary information of the same types to maintain the
confidentiality of any non-public information thereby received or received
pursuant to this Agreement except that disclosure of such information may be
made (i) to the subsidiaries or affiliates of Bank in connection with their
present or prospective business relations with Borrower, (ii) to prospective
transferees or purchasers of any interest in the Loans, provided that they have
entered into a comparable confidentiality agreement in favor of Borrower and
have delivered a copy to Borrower, (iii) as required by law, regulations, rule
or order, subpoena, judicial order or similar order, (iv) as may be required in
connection with the examination, audit or similar investigation of Bank and (v)
as Bank may determine in connection with the enforcement of any remedies
hereunder. Confidential information hereunder shall not include information that
either: (a) is in the public domain or in the knowledge or possession of Bank
when disclosed to Bank, or becomes part of the public domain after disclosure to
Bank through no fault of Bank; or (b) is disclosed to Bank by a third party,
provided Bank does not have actual knowledge that such third party is prohibited
from disclosing such information.

               IN WITNESS WHEREOF, the parties hereto have caused this Agreement
to be executed as of the date first above written.

                                             LYNX THERAPEUTICS, INC.

                                             By: /s/ Edward C. Albini
                                                --------------------------------
                                             Title: Chief Financial Officer
                                                   -----------------------------

                                             COMERICA BANK-CALIFORNIA

                                             By: /s/ Jonathan Norris
                                                --------------------------------
                                             Title: Vice President, Technology &
                                                    Life Sciences Group
                                                   -----------------------------

                                       19
<PAGE>

DEBTOR           LYNX THERAPEUTICS, INC.

SECURED PARTY:   COMERICA BANK-CALIFORNIA

                                    EXHIBIT A

                        COLLATERAL DESCRIPTION ATTACHMENT
                         TO LOAN AND SECURITY AGREEMENT

        All equipment of Borrower (herein referred to as "Borrower" or "Debtor")
financed by Bank, as listed on Appendix I attached hereto, and any additional
equipment financed by Bank (which financings shall be supported by a UCC filing
including an appendix listing such equipment), wherever located, and including
all accessions and additions thereto, and any and all cash proceeds and/or
noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or
for any right to payment.

        All terms above have the meanings given to them in the California
Uniform Commercial Code, as amended or supplemented from time to time, including
revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by
Stats. 1999, c.991 (S.B. 45), Section 35, operative July 1, 2001.

                                       20
<PAGE>

                                   Appendix I

                                       21

<PAGE>

                                    EXHIBIT B

                   LOAN PAYMENT/ADVANCE TELEPHONE REQUEST FORM

 EQUIPMENT ADVANCES: DEADLINE FOR PROCESSING IS 3:00 P.M. PACIFIC TIME THREE (3)
                       BUSINESS DAYS PRIOR TO ADVANCE DATE

TO:  TECHNOLOGY AND LIFE SCIENCES DIVISION                DATE:
                                                               -----------------
FAX #:  650-846-6840  ATTN:  COMPLIANCE                   TIME:
                                                               -----------------

--------------------------------------------------------------------------------

FROM: LYNX THERAPEUTICS, INC.
      --------------------------------------------------------------------------
                             CLIENT NAME (BORROWER)

REQUESTED BY:
             -------------------------------------------------------------------
                            AUTHORIZED SIGNER'S NAME

AUTHORIZED SIGNATURE:
                     -----------------------------------------------------------

PHONE NUMBER:
             -------------------------------------------------------------------

FROM ACCOUNT #                            TO ACCOUNT #
               --------------------------             --------------------------

<TABLE>
<CAPTION>
REQUESTED TRANSACTION TYPE                        REQUEST DOLLAR AMOUNT
--------------------------                        ---------------------
<S>                                               <C>
                                                  $
                                                   -----------------------------
PRINCIPAL INCREASE (EQUIPMENT ADVANCE)            E
PRINCIPAL PAYMENT (ONLY)                          $
                                                   -----------------------------
INTEREST PAYMENT (ONLY)                           $
                                                   -----------------------------
PRINCIPAL AND INTEREST (PAYMENT)                  $
                                                   -----------------------------
</TABLE>

OTHER INSTRUCTIONS:
                   -------------------------------------------------------------

--------------------------------------------------------------------------------

        All representations and warranties of Borrower stated in the Loan and
Security Agreement are true, correct and complete in all material respects as of
the date of the telephone request for an Equipment Advance confirmed by this
Borrowing Certificate; provided, however, that those representations and
warranties expressly referring to another date shall be true, correct and
complete in all material respects as of such date.
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
                                  BANK USE ONLY
--------------------------------------------------------------------------------

TELEPHONE REQUEST:

The following person is authorized to request the loan payment transfer/loan
advance on the advance designated account and is known to me.

-----------------------------------          -----------------------------------
     Authorized Requester                                 Phone #

-----------------------------------          -----------------------------------
      Received By (Bank)                                  Phone #

                  ---------------------------------------------

                                       22
<PAGE>

                           Authorized Signature (Bank)
--------------------------------------------------------------------------------

                                       23
<PAGE>

                                    EXHIBIT C
                             COMPLIANCE CERTIFICATE

TO:       COMERICA BANK-CALIFORNIA

FROM:     LYNX THERAPEUTICS, INC.

        The undersigned authorized officer of Lynx Therapeutics, Inc. hereby
certifies that in accordance with the terms and conditions of the Loan and
Security Agreement between Borrower and Bank (the "Agreement"), (i) Borrower is
in complete compliance for the period ending _______________ with all required
covenants except as noted below and (ii) all representations and warranties of
Borrower stated in the Agreement are true and correct as of the date hereof.
Attached herewith are the required documents supporting the above certification.
The Officer further certifies that these are prepared in accordance with
Generally Accepted Accounting Principles (GAAP) and are consistently applied
from one period to the next except as explained in an accompanying letter or
footnotes.

               PLEASE INDICATE COMPLIANCE STATUS BY CIRCLING YES/NO UNDER
"COMPLIES" COLUMN.

<TABLE>
<CAPTION>
   REPORTING COVENANT                                 REQUIRED                                       COMPLIES
   ------------------                                 --------                                      -----------
<S>                                                   <C>                                           <C>      <C>
   Monthly financial statements                       Monthly within 30 days                        Yes      No
   Annual (CPA Audited)                               FYE within 5 days of filing with SEC          Yes      No
   10K and 10Q                                        Within 5 days of filing with SEC              Yes      No
   Depository and operating accounts maintained
   with  Bank                                                                                       Yes      No
</TABLE>

<TABLE>
<CAPTION>
   FINANCIAL COVENANT                                   REQUIRED            ACTUAL          COMPLIES
   ------------------                                  -----------         ---------        ------------
<S>                                                    <C>                 <C>              <C>
   Maintain at all times, measured monthly:
     Liquidity                                         * See below         $________        Yes      No
     Minimum Cash Balance (maintained with Bank)       $5,000,000          $________        Yes      No
</TABLE>

        Liquidity. Borrower shall maintain at all times, measured as of the last
        day of each month, a balance of unrestricted cash which is greater than
        Borrower's Cash Burn, provided, however, this Section 6.8 shall be
        automatically deleted if Borrower provides Bank with evidence of
        Borrower's positive cash flow for six (6) consecutive monthly reporting
        periods. As used herein, "Cash Burn" shall mean the net change in
        Borrower's cash during the four months immediately preceding the date of
        measurement net of changes in debt, stock, paid-in capital and minority
        interests.

COMMENTS REGARDING EXCEPTIONS:  See Attached.

Sincerely,

-------------------------------------------------
SIGNATURE

-------------------------------------------------
TITLE

-------------------------------------------------
DATE

--------------------------------------------------------------------------------
BANK USE ONLY

Received by:
            -------------------------------------
                     AUTHORIZED SIGNER

Date:
      -------------------------------------------

Verified:
          ---------------------------------------
                     AUTHORIZED SIGNER

Date:
     --------------------------------------------

Compliance Status                 Yes          No
--------------------------------------------------------------------------------

                                       24
<PAGE>

                             SCHEDULE OF EXCEPTIONS

Permitted Indebtedness  (Section 1.1)

Indebtedness owing to Transamerica Business Credit Corporation pursuant to that
certain Master Loan and Security Agreement dated as of October 26, 1998, as
amended from time to time.

Permitted Investments (Section 1.1)

Approximately 40% ownership in Axaron Bioscience AG (f.k.a., BASF-LYNX
Bioscience AG), a joint venture company formed with BASF AG, located in
Heidelberg, Germany ("Axaron").

100% ownership in two foreign subsidiaries, (1) Lynx Therapeutics GmbH ("Lynx
GmbH") and (2) Lynx Therapeutics Beteiligungsgesellschaft mbH
("Beteiligungsgesellschaft mbH"), both of which are German limited liability
companies.

Permitted Liens (Section 1.1)

None.

Prior Names (Section 5.7)

None.

Litigation (Section 5.8)

None.

                                       25
<PAGE>

                         CORPORATE RESOLUTIONS TO BORROW

--------------------------------------------------------------------------------
BORROWER:      LYNX THERAPEUTICS, INC.
--------------------------------------------------------------------------------

        I, the undersigned Secretary or Assistant Secretary of LYNX
THERAPEUTICS, INC. (the "Corporation"), HEREBY CERTIFY that the Corporation is
organized and existing under and by virtue of the laws of the State of Delaware.

        I FURTHER CERTIFY that attached hereto as Attachments 1 and 2 are true
and complete copies of the Certificate of Incorporation, as amended, and the
Restated Bylaws of the Corporation, each of which is in full force and effect on
the date hereof.

        I FURTHER CERTIFY that at a meeting of the Directors of the Corporation,
duly called and held, at which a quorum was present and voting (or by other duly
authorized corporate action in lieu of a meeting), the following resolutions
were adopted.

        BE IT RESOLVED, that any one (1) of the following named officers,
employees, or agents of this Corporation, whose actual signatures are shown
below:

<TABLE>
<CAPTION>
       NAMES                          POSITION             ACTUAL SIGNATURES
---------------------          ---------------------       ---------------------
<S>                            <C>                         <C>

---------------------          ---------------------       ---------------------

---------------------          ---------------------       ---------------------

---------------------          ---------------------       ---------------------

---------------------          ---------------------       ---------------------
</TABLE>

acting for and on behalf of this Corporation and as its act and deed be, and
they hereby are, authorized and empowered:

        BORROW MONEY. To borrow from time to time from Comerica Bank-California
("Bank"), on such terms as may be agreed upon between the officers, employees,
or agents of the Corporation and Bank, such sum or sums of money as in their
judgment should be borrowed, without limitation.

        EXECUTE LOAN DOCUMENTS. To execute and deliver to Bank that certain Loan
and Security Agreement dated as of October 23, 2002 (the "Loan Agreement") and
any other agreement entered into between Corporation and Bank in connection with
the Loan Agreement, including any amendments, all as amended or extended from
time to time (collectively, with the Loan Agreement, the "Loan Documents"), and
also to execute and deliver to Bank one or more renewals, extensions,
modifications, refinancings, consolidations, or substitutions for the Loan
Documents, or any portion thereof.

        GRANT SECURITY. To grant a security interest to Bank in the Collateral
described in the Loan Documents, which security interest shall secure all of the
Corporation's Obligations, as described in the Loan Documents.

        NEGOTIATE ITEMS. To draw, endorse, and discount with Bank all drafts,
trade acceptances, promissory notes, or other evidences of indebtedness payable
to or belonging to the Corporation or in which the Corporation may have an
interest, and either to receive cash for the same or to cause such proceeds to
be credited to the account of the Corporation with Bank, or to cause such other
disposition of the proceeds derived therefrom as they may deem advisable.

        FURTHER ACTS. In the case of lines of credit, to designate additional or
alternate individuals as being authorized to request advances thereunder, and in
all cases, to do and perform such other acts and things, to pay any and all fees
and costs, and to execute and deliver such other documents and agreements as
they may in their discretion deem reasonably necessary or proper in order to
carry into effect the provisions of these Resolutions.

        BE IT FURTHER RESOLVED, that any and all acts authorized pursuant to
these resolutions and performed prior to the passage of these resolutions are
hereby ratified and approved, that these Resolutions shall remain in full force
and effect and Bank

                                       1
<PAGE>

may rely on these Resolutions until written notice of their revocation shall
have been delivered to and received by Bank. Any such notice shall not affect
any of the Corporation's agreements or commitments in effect at the time notice
is given.

        I FURTHER CERTIFY that the officers, employees, and agents named above
are duly elected, appointed, or employed by or for the Corporation, as the case
may be, and occupy the positions set forth opposite their respective names; that
the foregoing Resolutions now stand of record on the books of the Corporation;
and that the Resolutions are in full force and effect and have not been modified
or revoked in any manner whatsoever.

        IN WITNESS WHEREOF, I have hereunto set my hand on October 23, 2002 and
attest that the signatures set opposite the names listed above are their genuine
signatures.

                                                 CERTIFIED AND ATTESTED BY:

                                                 X
                                                  ------------------------------
--------------------------------------------------------------------------------

                                       2

<PAGE>

                            COMERICA BANK-CALIFORNIA
                                   MEMBER FDIC

                         ITEMIZATION OF AMOUNT FINANCED
                            DISBURSEMENT INSTRUCTIONS
                                   (TERM LOAN)

Name(s):  LYNX THERAPEUTICS, INC.                        Date:  October 23, 2002

    $           credited to deposit account No. ___________ when Equipment
                Advances are requested by Borrower

Amounts paid to others on your behalf:
    $10,000     to Comerica Bank-California for Loan Fee
    $           to Comerica Bank-California for Document Fee
    $           to Bank counsel fees and expenses
    $           to _______________
    $           to _______________
    $           TOTAL (AMOUNT FINANCED)

Upon consummation of this transaction, this document will also serve as the
authorization for Comerica Bank-California to disburse the loan proceeds as
stated above.

----------------------------------            ----------------------------------
          Signature                                       Signature

<PAGE>

                         AGREEMENT TO PROVIDE INSURANCE

TO:  COMERICA BANK-CALIFORNIA                  Date: October 23, 2002
     attn:  Collateral Operations, M/C 4604
     9920 South La Cienega Blvd, 14th Floor
     Inglewood, CA  90301                      Borrower: LYNX THERAPEUTICS, INC.

        In consideration of a loan in the amount of Two Million Dollars
($2,000,000), secured by equipment financed by Bank.

        I/We agree to obtain adequate insurance coverage to remain in force
during the term of the loan.

        I/We also agree to advise the below named agent to add Comerica
Bank-California as lender's loss payable on the new or existing insurance
policy, and to furnish Bank at above address with a copy of said
policy/endorsements and any subsequent renewal policies.

        I/We understand that the policy must contain:

        1. Fire and extended coverage in an amount sufficient to cover:

               (a)    The amount of the loan, OR

               (b)    All existing encumbrances, whichever is greater,

        But not in excess of the replacement value of the improvements on the
real property.

        2. Lender's "Loss Payable" Endorsement Form 438 BFU in favor of Comerica
Bank-California, or any other form acceptable to Bank.

                              INSURANCE INFORMATION

Insurance Co./Agent                                Telephone No.:

Agent's Address:

                 Signature of Obligor:
                                      --------------------------
                 Signature of Obligor:
                                      --------------------------

--------------------------------------------------------------------------------
FOR BANK USE ONLY

INSURANCE VERIFICATION: Date:
                             --------------------------

Person Spoken to:
                 --------------------------------------

Policy Number:
              -----------------------------------------

Effective From:                    To:
              --------------------     ----------------

Verified by:
            -------------------------------------------
--------------------------------------------------------------------------------

<PAGE>

--------------------------------------------------------------------------------
COMERICA BANK-CALIFORNIA
      MEMBER FDIC                             AUTOMATIC DEBIT AUTHORIZATION
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
To:  COMERICA BANK-CALIFORNIA

Re:  LOAN #
            -----------------------------------

You are hereby authorized and instructed to charge account No.
_________________________ in the name of LYNX THERAPEUTICS, INC.
--------------------------------------------------------------------------------
for principal and interest payments due on above referenced loan as set forth
below and credit the loan referenced above.

               [ X ] Debit each interest payment as it becomes due according to
               the terms of the note and any renewals or amendments thereof.

               [ X ] Debit each principal payment as it becomes due according to
               the terms of the note and any renewals or amendments thereof.

This Authorization is to remain in full force and effect until revoked in
writing.

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
       Borrower Signature                                   Date
----------------------------------            ----------------------------------

                                                     October 23, 2002
----------------------------------            ----------------------------------

----------------------------------            ----------------------------------

<PAGE>

DEBTOR:            LYNX THERAPEUTICS, INC.

SECURED PARTY:     COMERICA BANK-CALIFORNIA

                                    EXHIBIT A

                        COLLATERAL DESCRIPTION ATTACHMENT
                           TO UCC FINANCING STATEMENT

        All equipment of Borrower (herein referred to as "Borrower" or "Debtor")
financed by Bank, as listed on Appendix I attached hereto, and any additional
equipment financed by Bank (which financings shall be supported by a UCC filing
including an appendix listing such equipment), wherever located, and including
all accessions and additions thereto, and any and all cash proceeds and/or
noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or
for any right to payment.

        All terms above have the meanings given to them in the California
Uniform Commercial Code, as amended or supplemented from time to time, including
revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by
Stats. 1999, c.991 (S.B. 45), Section 35, operative July 1, 2001.

<PAGE>

                                   Appendix I

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