Document:

EX-4.10

 Exhibit 4.10 

EIGHTH SUPPLEMENTAL INDENTURE 

Eighth Supplemental Indenture (this “Supplemental Indenture”), dated as of December 10, 2013, among Adheris, LLC, a
Delaware limited liability company (the “Guaranteeing Subsidiary”), a subsidiary of inVentiv Health, Inc., a Delaware corporation (the “Issuer”), and Wilmington Trust, National Association, as successor by merger to
Wilmington Trust FSB, as trustee (the “Trustee”). 
 W I T N E S S E T H 

WHEREAS, inVentiv Health, Inc. and the Guarantors (as defined in the Indenture referred to below) have heretofore executed and delivered to
the Trustee an Indenture (the “Indenture”), dated as of August 4, 2010, providing for the issuance of an unlimited aggregate principal amount of 10% Senior Notes due 2018; 

WHEREAS, the Indenture provides that under certain circumstances the Guaranteeing Subsidiary shall execute and deliver to the Trustee a
supplemental indenture pursuant to which the Guaranteeing Subsidiary shall unconditionally guarantee all of the Issuer’s Obligations under the Notes and the Indenture on the terms and conditions set forth herein and under the Indenture (the
“Guarantee”); and 
 WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and
deliver this Supplemental Indenture. 
 NOW THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the
receipt of which is hereby acknowledged, the parties mutually covenant and agree for the equal and ratable benefit of the Holders as follows: 

(1) Capitalized Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture. 

(2) Agreement to Guarantee. The Guaranteeing Subsidiary hereby agrees as follows: 

(a) Along with all other Guarantors named in the Indenture (including pursuant to any supplemental indentures), to jointly and
severally unconditionally guarantee to each Holder of a Note authenticated and delivered by the Trustee and to the Trustee and its successors and assigns, irrespective of the validity and enforceability of the Indenture, the Notes or the obligations
of the Issuer hereunder or thereunder, that: 
 (i) the principal of and interest and premium, if any, on the Notes shall be
promptly paid in full when due, whether at maturity, by acceleration, redemption or otherwise, and interest on the overdue principal of and interest on the Notes, if any, if lawful, and all other obligations of the Issuer to the Holders or the
Trustee thereunder shall be promptly paid in full, all in accordance with the terms thereof; and 
 (ii) in case of any
extension of time of payment or renewal of any Notes or any of such other obligations, that same shall be promptly paid in full when due in accordance with the terms of the extension or renewal, whether at stated maturity, by acceleration or
otherwise. Failing payment when due of any amount so guaranteed for whatever reason, the Guarantors and the Guaranteeing Subsidiary shall be jointly and severally obligated to pay the same immediately. This is a guarantee of payment and not a
guarantee of collection. 
 (b) The obligations hereunder shall be unconditional, irrespective of the validity, regularity or
enforceability of the Notes or the Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder with respect to any provisions hereof or thereof, the recovery of any judgment against the Issuer or any other
Guarantor, any action to enforce the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense of a guarantor. 

 (c) The Guaranteeing Subsidiary hereby waives: diligence, presentment, demand of
payment, filing of claims with a court in the event of insolvency or bankruptcy of the Issuer, any right to require a proceeding first against the Issuer, protest, notice and all demands whatsoever. 

(d) This Guarantee shall not be discharged except by full payment of the obligations contained in the Notes, the Indenture and
this Supplemental Indenture. The Guaranteeing Subsidiary accepts all obligations applicable to a Guarantor under the Indenture, including Article 10 of the Indenture (which is deemed incorporated in this Supplemental Indenture and applicable to this
Guarantee). The Guaranteeing Subsidiary acknowledges that by executing this Supplemental Indenture, it will become a Guarantor under the Indenture and subject to all the terms and conditions applicable to Guarantors contained therein. 

(e) If any Holder or the Trustee is required by any court or otherwise to return to the Issuer, the Guarantors (including the
Guaranteeing Subsidiary), or any custodian, trustee, liquidator or other similar official acting in relation to either the Issuer or the Guarantors, any amount paid either to the Trustee or such Holder, this Guarantee, to the extent theretofore
discharged, shall be reinstated in full force and effect. 
 (f) The Guaranteeing Subsidiary shall not be entitled to any
right of subrogation in relation to the Holders in respect of any obligations guaranteed hereby until payment in full of all obligations guaranteed hereby. 

(g) As between the Guaranteeing Subsidiary, on the one hand, and the Holders and the Trustee, on the other hand, (x) the
maturity of the obligations guaranteed hereby may be accelerated as provided in Article 6 of the Indenture for the purposes of this Guarantee, notwithstanding any stay, injunction or other prohibition preventing such acceleration in respect of the
obligations guaranteed hereby, and (y) in the event of any declaration of acceleration of such obligations as provided in Article 6 of the Indenture, such obligations (whether or not due and payable) shall forthwith become due and payable by
the Guaranteeing Subsidiaries for the purpose of this Guarantee. 
 (h) The Guaranteeing Subsidiary shall have the right to
seek contribution from any non-paying Guarantor so long as the exercise of such right does not impair the rights of the Holders under this Guarantee. 

(i) Pursuant to Section 10.02 of the Indenture, after giving effect to all other contingent and fixed liabilities that are
relevant under any applicable Bankruptcy or fraudulent conveyance laws, and after giving effect to any collections from, rights to receive contribution from or payments made by or on behalf of any other Guarantor in respect of the obligations of
such other Guarantor under Article 10 of the Indenture, this new Guarantee shall be limited to the maximum amount permissible such that the obligations of such Guarantor under this Guarantee will not constitute a fraudulent transfer or conveyance.

 (j) This Guarantee shall remain in full force and effect and continue to be effective should any petition be filed by or
against the Issuer for liquidation, reorganization, should the Issuer become insolvent or make an assignment for the benefit of creditors or should a receiver or trustee be appointed for all or any significant part of the Issuer’s assets, and
shall, to the fullest extent permitted by law, continue to be effective or be reinstated, as the case may be, if at any time payment and performance of the Notes are, pursuant to applicable law, rescinded or reduced in amount, or must otherwise be
restored or returned by any obligee on the Notes and Guarantee, whether as a “voidable preference,” “fraudulent transfer” or otherwise, all as though such payment or performance had not been made. In the event that any payment or
any part thereof, is rescinded, reduced, restored or returned, the Note shall, to the fullest extent permitted by law, be reinstated and deemed reduced only by such amount paid and not so rescinded, reduced, restored or returned. 

(k) In case any provision of this Guarantee shall be invalid, illegal or unenforceable, the validity, legality, and
enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

  
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 (l) This Guarantee shall be a general unsecured senior obligation of the
Guaranteeing Subsidiary, ranking equally in right of payment with all existing and future Senior Indebtedness of the Guaranteeing Subsidiary, if any. 

(m) Each payment to be made by the Guaranteeing Subsidiary in respect of this Guarantee shall be made without set-off,
counterclaim, reduction or diminution of any kind or nature. 
 (3) Execution and Delivery. The Guaranteeing Subsidiary agrees that
the Guarantee shall remain in full force and effect notwithstanding the absence of the endorsement of any notation of such Guarantee on the Notes. 

(4) Merger, Consolidation or Sale of All or Substantially All Assets. 

(a) Except as otherwise provided in Section 5.01(c) of the Indenture, the Guaranteeing Subsidiary may not consolidate, amalgamate or
merge with or into or wind up into (whether or not the Guaranteeing Subsidiary is the surviving Person), or sell, assign, transfer, lease, convey or otherwise dispose of all or substantially all of its properties or assets, in one or more related
transactions, to any Person unless: 
 (i) (A) the Guaranteeing Subsidiary is the surviving Person or the Person formed
by or surviving any such consolidation, amalgamation or merger (if other than the Guaranteeing Subsidiary) or to which such sale, assignment, transfer, lease, conveyance or other disposition will have been made is a Person organized or existing
under the laws of the jurisdiction of organization of the Guaranteeing Subsidiary, as applicable, or the laws of the United States, any state thereof, the District of Columbia, or any territory thereof (the surviving Guaranteeing Subsidiary or such
Person, as the case may be, being herein called the “Successor Person”); 
 (B) the Successor Person, if
other than the Guaranteeing Subsidiary, expressly assumes all the obligations of the Guaranteeing Subsidiary under the Indenture and the Guaranteeing Subsidiary’s related Guarantee pursuant to supplemental indentures or other documents or
instruments as necessary; 
 (C) immediately after such transaction, no Default exists; and 

(D) the Issuer shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that
such consolidation, merger, amalgamation or transfer and such supplemental indentures, if any, comply with this Indenture; or 

(ii) the transaction is made in compliance with Section 4.10 of the Indenture; or 

(iii) such property or assets constitute Equity Interests of Restricted Subsidiaries that are not Guarantors, which Equity
Interests are sold, assigned, transferred, leased, conveyed or otherwise disposed to Restricted Subsidiaries that are not Guarantors. 
 (b)
Subject to certain limitations described in the Indenture, the Successor Person will succeed to, and be substituted for, the Guaranteeing Subsidiary under the Indenture and the Guaranteeing Subsidiary’s Guarantee. Notwithstanding the foregoing,
the Guaranteeing Subsidiary may merge or consolidate with or into, wind up into or transfer all or part of its properties and assets to another Guarantor or the Issuer. 

(5) Releases. The Guarantee of the Guaranteeing Subsidiary shall be automatically and unconditionally released and discharged, and no
further action by the Guaranteeing Subsidiary, the Issuer or the Trustee is required for the release of the Guaranteeing Subsidiary’s Guarantee, upon: 

(a) (i) any sale, exchange, disposition or transfer (by merger, amalgamation, consolidation or otherwise) of (x) the
Capital Stock of the Guaranteeing Subsidiary, after which the the Guaranteeing Subsidiary is no longer a Restricted Subsidiary, (y) all the assets of such Guarantor or (z) if such Guarantor is not at such time a guarantor of the Senior
Secured Credit Facilities, all or substantially all the assets of the Guaranteeing Subsidiary, in each case if such sale, exchange, disposition or transfer is made in compliance with the applicable provisions of this Indenture; 

  
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 (ii) the release or discharge of the guarantee by the Guaranteeing Subsidiary of
Indebtedness under the Senior Secured Credit Facilities, or such other guarantee that resulted in the creation of such Guarantee, except a discharge or release by or as a result of payment under such guarantee (it being understood that a release
subject to a contingent reinstatement is still a release, and that if any such Guarantee is so reinstated, such Guarantee shall also be reinstated to the extent that the Guaranteeing Subsidiary would then be required to provide a Guarantee pursuant
to Section 4.15 in the Indenture); 
 (iii) the designation of any Restricted Subsidiary that is a Guaranteeing
Subsidiary as an Unrestricted Subsidiary in compliance with the applicable provisions of the Indenture; or 
 (iv) the
exercise by the Issuer of its Legal Defeasance option or Covenant Defeasance option in accordance with Article 8 of the Indenture or the discharge of the Issuer’s obligations under this Indenture in accordance with the terms of the Indenture;
and 
 (b) the Guaranteeing Subsidiary delivering to the Trustee an Officer’s Certificate and an Opinion of Counsel,
each stating that all conditions precedent provided for in this Indenture relating to such transaction have been complied with. 
 (6) No
Recourse Against Others. No past, present or future director, officer, employee, incorporator, member, partner or stockholder of the Guaranteeing Subsidiary (other than the Issuer and the Guarantors) shall have any liability for any obligations
of the Issuer or the Guarantors (including the Guaranteeing Subsidiary) under the Notes, any Guarantees, the Indenture or this Supplemental Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each
Holder by accepting Notes waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

(7) Governing Law. THIS SUPPLEMENTAL INDENTURE WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 (8) Counterparts. The parties may sign any number of copies of this Supplemental Indenture. Each signed copy shall be an original,
but all of them together represent the same agreement. 
 (9) Effect of Headings. The Section headings herein are for convenience
only and shall not affect the construction hereof. 
 (10) The Trustee. The Trustee shall not be responsible in any manner whatsoever
for or in respect of the validity or sufficiency of this Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Guaranteeing Subsidiary. 

(11) Subrogation. The Guaranteeing Subsidiary shall be subrogated to all rights of Holders against the Issuer in respect of any amounts
paid by the Guaranteeing Subsidiary pursuant to the provisions of Section 2 hereof and Section 10.01 of the Indenture; provided that, if an Event of Default has occurred and is continuing, the Guaranteeing Subsidiary shall not be
entitled to enforce or receive any payments arising out of, or based upon, such right of subrogation until all amounts then due and payable by the Issuer under the Indenture or the Notes shall have been paid in full. 

(12) Benefits Acknowledged. The Guaranteeing Subsidiary’s Guarantee is subject to the terms and conditions set forth in the
Indenture. The Guaranteeing Subsidiary acknowledges that it will receive direct and indirect benefits from the financing arrangements contemplated by the Indenture and this Supplemental Indenture and that the guarantee and waivers made by it
pursuant to this Guarantee are knowingly made in contemplation of such benefits. 

  
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 (13) Successors. All agreements of the Guaranteeing Subsidiary in this Supplemental
Indenture shall bind its Successors, except as otherwise provided in this Supplemental Indenture. All agreements of the Trustee in this Supplemental Indenture shall bind its successors. 

[Signature pages follow.] 

  
 - 5 - 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed, all as of the date first above written. 
  

					
	ADHERIS, LLC
		
	By:	 	 /s/ Richard Veith

		 	Name:	 	Richard Veith
		 	Title:	 	Vice President & Treasurer

  
 [Signature Page to the
Supplemental Indenture for Senior Notes] 

 
					
	INVENTIV HEALTH, INC.
		
	By:	 	 /s/ Richard Veith

		 	Name:	 	Richard Veith
		 	Title:	 	Vice President & Treasurer

  
 [Signature Page to the
Supplemental Indenture for Senior Notes] 

 
					
	 WILMINGTON TRUST, NATIONAL ASSOCIATION,

as Trustee

		
	By:	 	 /s/ Joseph P O’Donnell

		 	Name:	 	Joseph P O’Donnell
		 	Title:	 	Vice President

  
 Signature Page to the
Supplemental Indenture for the Senior Unsecured NotesEX-4.11

 Exhibit 4.11 

NINTH SUPPLEMENTAL INDENTURE 

Ninth Supplemental Indenture (this “Ninth Supplemental Indenture”), dated as August 12, 2014, is entered into by and
among inVentiv Health, Inc., a Delaware corporation (the “Issuer”), the Guarantors (as defined in the Indenture referred to below) and Wilmington Trust, National Association, as trustee (the “Trustee”). 

W I T N E S S E T H 
 WHEREAS,
the Issuer and the Guarantors have heretofore executed and delivered to the Trustee an Indenture, dated as of August 4, 2010, providing for the issuance of an unlimited aggregate principal amount of 10.0% Senior Notes due 2018, which Indenture
was further supplemented by the First Supplemental Indenture, dated as of September 1, 2010, the Second Supplemental Indenture, dated as of February 11, 2011, the Third Supplemental Indenture, dated as of June 10, 2011, the Fourth
Supplemental Indenture, dated as of July 13, 2011, the Fifth Supplemental Indenture, dated as of April 30, 2012, the Sixth Supplemental Indenture, dated as of December 20, 2012, the Seventh Supplemental Indenture, dated as of
February 7, 2013, and the Eighth Supplemental Indenture, dated as of December 10, 2013 (as may be further amended, supplemented or otherwise modified from time to time, the “Indenture”); 

WHEREAS, Section 2.01 and Section 9.01 of the Indenture provide that the Issuer, the Guarantors and the Trustee may enter into
supplemental indentures to, among other things, provide for (i) the issuance of Additional Notes in accordance with the provisions of the Indenture and (ii) to make any amendment to the provisions of the Indenture relating to the transfer
and legending of Notes as permitted by the Indenture; 
 WHEREAS, the Issuer has duly authorized the issuance, delivery and authentication
by the Trustee, of Additional Notes in an aggregate principal amount of $26,316,000 having the same terms as the Initial Notes (the “Additional Notes”), to be evidenced by new Global Notes evidencing the Additional Notes
substantially in the form of Exhibit A hereto, and each of the Issuer, the Guarantors and the Trustee has duly authorized the execution and delivery of this Ninth Supplemental Indenture; 

WHEREAS, the Issuer seeks to amend the provisions of the Indenture relating to the transfer and legending of the Notes; and 

WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and deliver this Ninth Supplemental Indenture.

 NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby
acknowledged, the parties mutually covenant and agree for the equal and ratable benefit of the Holders as follows: 
 SECTION 1.
Capitalized Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture. 

SECTION 2. Additional Notes. The terms of the Additional Notes shall be governed under the Indenture and executed and delivered in the
manner contemplated therein and each of the Guarantors shall guarantee such Additional Notes as set forth in Article 10 of the Indenture. The purchasers of the Additional Notes shall not have any rights under a Registration Rights Agreement. The
Issuer and each of the Guarantors hereby consents to the terms and conditions of this Ninth Supplemental Indenture and the Additional Notes, subject to the limitations, if any, set forth herein. 

 SECTION 3 Amendment to Exhibit B, Transfer Certificate. Exhibit B shall be replaced in its
entirety with Exhibit B attached hereto. 
 SECTION 4 Amendments to Section 2.06 of the Indenture. 

(a) The text of Section 2.06(c)(i) of the Indenture shall be deleted in its entirety and replaced with the following text: 

“(i) Beneficial Interests in Restricted Global Notes to Restricted Definitive Notes. If any holder of a beneficial interest in a
Restricted Global Note proposes to exchange such beneficial interest for a Restricted Definitive Note or to transfer such beneficial interest to a Person who takes delivery thereof in the form of a Restricted Definitive Note, then, upon the
occurrence of any of the events in Section 2.06(a) hereof and receipt by the Registrar of the following documentation: 

(A) if the holder of such beneficial interest in a Restricted Global Note proposes to exchange such beneficial interest for a
Restricted Definitive Note, a certificate from such holder substantially in the form of Exhibit C hereto, including the certifications in item (2)(a) thereof; 

(B) if such beneficial interest is being transferred to a QIB in accordance with Rule 144A, a certificate substantially in the
form of Exhibit B hereto, including the certifications in item (1) thereof; 
 (C) if such beneficial interest is being
transferred to a Non-U.S. Person in an offshore transaction in accordance with Rule 903 or Rule 904, a certificate substantially in the form of Exhibit B hereto, including the certifications in item (2) thereof; 

(D) if such beneficial interest is being transferred pursuant to an exemption from the registration requirements of the
Securities Act in accordance with Rule 144, a certificate substantially in the form of Exhibit B hereto, including the certifications in item (3)(a) thereof; 

(E) if such beneficial interest is being transferred to the Issuer or any of its Subsidiaries, a certificate substantially in
the form of Exhibit B hereto, including the certifications in item (3)(b) thereof; 
 (F) if such beneficial interest is
being transferred to an “accredited investor” as defined in Rule 501 of the Securities Act (“Accredited Investor”) in reliance on an exemption from the registration requirements of the Securities Act, a certificate substantially
in the form of Exhibit B hereto, including the certifications in item (3)(c) thereof; or 
 (G) if such beneficial
interest is being transferred pursuant to an effective registration statement under the Securities Act, a certificate substantially in the form of Exhibit B hereto, including the certifications in item (3)(d) thereof, 

the Trustee shall cause the aggregate principal amount of the applicable Global Note to be reduced accordingly pursuant to Section 2.06(h) hereof, and
the Issuer shall execute and the Trustee shall, upon receipt of an Authentication Order, authenticate and mail to the Person designated in the instructions a Definitive Note in the applicable principal amount. Any Definitive Note issued in exchange
for a beneficial interest in a Restricted Global Note pursuant to this Section 2.06(c) shall be registered in such name or names and in such authorized denomination or denominations as the holder of such beneficial interest shall instruct the
Registrar through instructions from the Depositary and the Participant or Indirect Participant. The Trustee shall mail such Definitive Notes to the Persons in whose names such Notes are so registered. Any Definitive Note issued in exchange for a
beneficial interest in a Restricted Global Note pursuant to this Section 2.06(c)(i) shall bear the Private Placement Legend and shall be subject to all restrictions on transfer contained therein.” 

  
 2 

 (b) The text of 2.06(d)(i) of the Indenture shall be deleted in its entirety and replaced with
the following text: 
 “(i) Restricted Definitive Notes to Beneficial Interests in Restricted Global Notes. If any Holder of a
Restricted Definitive Note proposes to exchange such Note for a beneficial interest in a Restricted Global Note or to transfer such Restricted Definitive Note to a Person who takes delivery thereof in the form of a beneficial interest in a
Restricted Global Note, then, upon receipt by the Registrar of the following documentation: 
 (A) if the Holder of such
Restricted Definitive Note proposes to exchange such Note for a beneficial interest in a Restricted Global Note, a certificate from such Holder substantially in the form of Exhibit C hereto, including the certifications in item (2)(b) thereof;

 (B) if such Restricted Definitive Note is being transferred to a QIB in accordance with Rule 144A, a certificate
substantially in the form of Exhibit B hereto, including the certifications in item (1) thereof; 
 (C) if such
Restricted Definitive Note is being transferred to a Non-U.S. Person in an offshore transaction in accordance with Rule 903 or Rule 904, a certificate substantially in the form of Exhibit B hereto, including the certifications in item
(2) thereof; 
 (D) if such Restricted Definitive Note is being transferred pursuant to an exemption from the
registration requirements of the Securities Act in accordance with Rule 144, a certificate substantially in the form of Exhibit B hereto, including the certifications in item (3)(a) thereof; 

(E) if such Restricted Definitive Note is being transferred to the Issuer or any of its Subsidiaries, a certificate
substantially in the form of Exhibit B hereto, including the certifications in item (3)(b) thereof; 
 (F) if such
Restricted Definitive Note is being transferred to an Accredited Investor in reliance on an exemption from the registration requirements of the Securities Act other than those listed in paragraphs (B) through (D) above, a certificate from
such Holder in the form of Exhibit B, including the certifications of item 3(c) thereof; or 
 (G) if such Restricted
Definitive Note is being transferred pursuant to an effective registration statement under the Securities Act, a certificate substantially in the form of Exhibit B hereto, including the certifications in item (3)(d) thereof, 

the Trustee shall cancel the Restricted Definitive Note and increase or cause to be increased the aggregate principal amount of, in the case of clause
(A) above, the applicable Restricted Global Note, in the case of clause (B) above, the applicable 144A Global Note and in the case of clause (C) above, the applicable Regulation S Global Note.” 

(c) The text of 2.06(g)(i)(A) of the Indenture shall be deleted in its entirety and replaced with the following text: 

“(i) Private Placement Legend. 

Except as permitted by subparagraph (B) below, each Global Note and each Definitive Note (and all Notes issued in exchange therefor or
substitution thereof) shall bear the legend in substantially the following form: 
 “THIS NOTE HAS NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED IN THE 

  
 3 

 
ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS NOTE AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR
ACCOUNT FOR THE BENEFIT OF THE ISSUER THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE TRANSFER THIS NOTE OR ANY BENEFICIAL INTEREST HEREIN, EXCEPT IN ACCORDANCE WITH THE SECURITIES ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED
STATES AND ONLY 
 (A) TO THE ISSUER, 

(B) PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT, 

(C) TO A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT, 

(D) IN AN OFFSHORE TRANSACTION IN COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE SECURITIES ACT, 

(E) IN A PRINCIPAL AMOUNT OF NOT LESS THAN $100,000, TO AN ACCREDITED INVESTOR THAT, PRIOR TO SUCH TRANSFER, DELIVERS TO THE
TRUSTEE A DULY COMPLETED AND SIGNED CERTIFICATE (THE FORM OF WHICH IS ATTACHED AS AN EXHIBIT TO THE INDENTURE) RELATING TO THE RESTRICTIONS ON TRANSFER OF THIS NOTE, OR 

(F) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT OR ANY OTHER AVAILABLE EXEMPTION
FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 
 PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH (C) ABOVE OR
(D) ABOVE, A DULY COMPLETED AND SIGNED CERTIFICATE (THE FORM OF WHICH IS ATTACHED AS AN EXHIBIT TO THE INDENTURE) MUST BE DELIVERED TO THE TRUSTEE. PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH (E) OR (F) ABOVE, THE
ISSUER RESERVES THE RIGHT TO REQUIRE THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY BE REQUIRED IN ORDER TO DETERMINE THAT THE PROPOSED TRANSFER IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND
APPLICABLE STATE SECURITIES LAWS. NO REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY RULE 144 EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT.”” 

  
 4 

 SECTION 5. Governing Law. THIS NINTH SUPPLEMENTAL INDENTURE WILL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 SECTION 6. Counterparts. The parties may sign any number of copies
of this Ninth Supplemental Indenture by telecopier, facsimile or other electronic transmission (i.e., a “pdf” or “tif”). Each signed copy shall be deemed an original, but all of them together represent the same agreement. 

SECTION 7. Effect of Headings. The Section headings herein are for convenience only and shall not affect the construction hereof. 

SECTION 8. The Trustee. The Trustee shall not be responsible in any manner whatsoever for or in respect of the validity or sufficiency
of this Ninth Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Issuer and the Guarantors. 

SECTION 9. Successors. All agreements of the Issuer and each Guarantor in this Ninth Supplemental Indenture shall bind its successors,
except as otherwise provided in this Ninth Supplemental Indenture. All agreements of the Trustee in this Ninth Supplemental Indenture shall bind its successors. 

[Remainder of Page Intentionally Left Blank] 

  
 5 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed, all as of the date first above written. 
  

					
	INVENTIV HEALTH, INC.
		
	By:	 	 /s/ Eric Sherbet

		 	Name:	 	Eric Sherbet
		 	Title:	 	General Counsel & Secretary

  
 Signature Page to
Supplemental Indenture 

									
	 ADDISON WHITNEY LLC
  

CHANDLER CHICCO COMPANIES LLC
  

IGNITE HEALTH LLC
  

INVENTIV ADVANCE INSIGHTS, INC.
  

INVENTIV COMMUNICATIONS, INC.
  

INVENTIV MEDICAL MANAGEMENT LLC
  

IVH LOGISTICS SOLUTIONS, LLC
  

IVH RESEARCH ASSOCIATES, INC.
  

INVENTIV HEALTH CLINICAL, INC.
  

INVENTIV CLINICAL, LLC
  

INVENTIV HEALTH CLINICAL LAB, INC.
  

INVENTIV HEALTH CLINICAL, LLC
  

INVENTIV HEALTH CLINICAL SRS, LLC
  

INVENTIV PATIENT ACCESS SOLUTIONS, LLC
  

PATIENT MARKETING GROUP LLC
  

PDGI HOLDCO, INC.
  

PHARMA HOLDINGS, INC.
  

PHARMANET FAR, LLC
  

PHARMANET RESOURCE SOLUTIONS, LLC
  

PHARMASOFT, LLC
  

SOUTH FLORIDA KINETICS, INC.
  

VENTIV COMMERCIAL SERVICES, LLC
  

ADHERIS, INC.
  

ADHERIS, LLC
  

ALLIDURA COMMUNICATIONS, LLC
  

AXCELO MSL SOLUTIONS, LLC
  

BIOSECTOR 2 LLC
	 		 	 BLUE DIESEL, LLC

 
 BRANDTECTONICS, L.L.C.

 
 CADENT MEDICAL COMMUNICATIONS, LLC

 
 CAMPBELL ALLIANCE GROUP, INC.

 
 CAMPBELL ALLIANCE, LTD.

 
 CHAMBERLAIN COMMUNICATIONS GROUP LLC

 
 CHANDLER CHICCO AGENCY, L.L.C.

 
 CHANDLER CHICCO PRODUCTIONS LLC

 
 ENCUITY RESEARCH, LLC

 
 GERBIG, SNELL/WEISHEIMER ADVERTISING, LLC

 
 INCHORD HOLDING CORPORATION

 
 INTERPHAZ BIOCONSULTING, LLC

 
 INVENTIV DIGITAL + INNOVATION, LLC

 
 INVENTIV HEALTH CLINICAL SRE, LLC

 
 INVENTIV HEALTH CLINICAL STAFFING SERVICES,
LLC
  
 INVENTIV MEDICAL COMMUNICATIONS, LLC

 
 LITMUS MEDICAL MARKETING SERVICES LLC

 
 MEDCONFERENCE LLC

 
 NAVICOR GROUP, LLC

 
 PALIO + IGNITE, LLC

 
 PARAGONRX INTERNATIONAL LLC

 
 PHARMACEUTICAL INSTITUTE, INC.

 
 PNET US, LLC

 
 RAVEN HOLDCO LLC

 
 THE CENTER FOR BIOMEDICAL CONTINUING EDUCATION,
LLC
  
 THE SELVA GROUP, LLC

 
 as Guarantors

				
		 		 	By:	 	 /s/ Eric Sherbet

		 		 		 	Name:	 	Eric Sherbet
		 		 		 	Title:	 	Vice President and Secretary

  
 Signature Page to
Supplemental Indenture 

 
					
	 WILMINGTON TRUST, NATIONAL ASSOCIATION,

as Trustee

		
	By:	 	 /s/ Lynn M. Steiner

		 	Name:	 	Lynn M. Steiner
		 	Title:	 	Vice President

  
 [SIGNATURE PAGE TO NINTH
SUPPLEMENTAL INDENTURE] 

 EXHIBIT A 

CUSIP 46122E AJ4 
 ISIN US46122EAJ47 

NOTE 
 10% Senior Note due 2018

  

					
	No.     	  		  	[$        ]

 inVentiv Health, Inc., a Delaware corporation, promises to pay to
             or registered assigns the principal sum of          Dollars on August 15, 2018. 

Interest Payment Dates: February 15 and August 15, commencing on February 15, 2015. 

Record Dates: February 1 and August 1 

  
 A-1 

 IN WITNESS HEREOF, the Issuer has caused this instrument to be duly executed. 

Dated: August 12, 2014 
  

					
	INVENTIV HEALTH, INC.
		
	By:	 	  

		 	Name:	 	Jonathan E. Bicknell
		 	Title:	 	Interim Chief Financial Officer

  
 A-2 

 
			
	 This is one of the Notes referred to in the within-mentioned Indenture:

 
 WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee

		
	By:	 	  

		 	Authorized Signatory
		 	Date: August 12, 2014

  
 A-3 

 10% Senior Note due 2018 

Capitalized terms used herein shall have the meanings assigned to them in the Indenture referred to below unless otherwise indicated. 

1. Interest. inVentiv Health, Inc., a Delaware corporation, promises to pay interest on the principal amount of this Note at a rate per
annum of 10% from August 15, 2014 until maturity. The Issuer will pay interest on this Note semiannually in arrears on February 15 and August 15 of each year beginning February 15, 2015, or if any such day is not a Business Day,
on the next succeeding Business Day (each, an “Interest Payment Date”). The Issuer will make each interest payment to the Holder of record of this Note on the immediately preceding February l and August 1 (each, a
“Record Date”). Interest on this Note will accrue from August 15, 2014. The Issuer will pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue principal and premium, if any, from
time to time on demand at the rate borne by this Note; it shall pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue installments of interest (without regard to any applicable grace periods) from time
to time on demand at the rate borne by this Note. Interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. 

2. Method of Payment. The Issuer will pay interest on this Note to the Person who is the registered Holder of this Note at the close of
business on the Record Date (whether or not a Business Day) next preceding the Interest Payment Date, even if this Note is cancelled after such record date and on or before such Interest Payment Date, except as provided in Section 2.12 of the
Indenture with respect to defaulted interest. Payment of interest may be made by check mailed to the Holders at their addresses set forth in the Note Register of Holders, provided that (a) all cash payments of principal, premium, if any,
and interest on, Notes represented by Global Notes registered in the name of or held by DTC or its nominee will be made by wire transfer of immediately available funds to the accounts specified by the Holder or Holders thereof and (b) all
payments of principal, premium, if any, and interest with respect to certificated Notes will be made by wire transfer to a U.S. dollar account maintained by the payee with a bank in the United States if such Holder elects payment by wire transfer by
giving written notice to the Trustee or the Paying Agent to such effect designating such account no later than 30 days immediately preceding the relevant due date for payment (or such other date as the Trustee may accept in its discretion). Such
payment shall be in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

3. Paying Agent, Transfer Agent and Registrar. Initially, Wilmington Trust, National Association, as successor by merger to Wilmington
Trust FSB, the Trustee under the Indenture, will act as Paying Agent, Transfer Agent and Registrar. The Issuer may change any Paying Agent, Transfer Agent or Registrar without notice to the Holders. The Issuer or any of its Subsidiaries may act in
any such capacity. 
 4. Indenture. The Issuer issued the Notes under a ninth supplemental indenture, dated as of August 12,
2014, by and among inVentiv Health, Inc., certain guarantors party thereto, and the Trustee, to the Indenture, dated as of August 4, 2010 (the “Indenture”), among inVentiv Health, Inc., the guarantors named therein and the
Trustee. This Note is one of 

  
 A-4 

 
a duly authorized issue of notes of the Issuer designated as its 10% Senior Notes due 2018. The Issuer shall be entitled to issue Additional Notes pursuant to Sections 2.01 and 4.09 of the
Indenture. The terms of the Notes include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”). The Notes are subject to all such
terms, and Holders are referred to the Indenture and such Act for a statement of such terms. To the extent any provision of this Note conflicts with the express provisions of the Indenture, the provisions of the Indenture shall govern and be
controlling. 
 5. Optional Redemption. 

(a) Except as described below under clauses 5(b) and 5(c) hereof the Notes will not be redeemable at the Issuer’s option. 

(b) At any time prior to August 15, 2014, the Issuer may redeem all or a part of the Notes upon notice in accordance with
Section 3.02 and 3.03 of the Indenture, at a redemption price equal to 100.0% of the principal amount of the Notes redeemed plus the Applicable Premium as of, plus accrued and unpaid interest, if any, to the date of redemption (the
“Redemption Date”), subject to the right of Holders of record on the relevant record date to receive interest due on the relevant Interest Payment Date. 

(c) On or after August 15, 2014, the Issuer may redeem the Notes, upon notice in accordance with Sections 3.02 and Section 3.03 of
the Indenture, at the redemption prices (expressed as percentages of principal amount of the Notes to be redeemed) set forth below, plus accrued and unpaid interest, if any, thereon to the applicable Redemption Date, subject to the right of Holders
of record on the relevant record date to receive interest due on the relevant Interest Payment Date, if redeemed during the twelve-month period beginning on August 15 of each of the years indicated below: 

 

					
	 Year
	  	Percentage	 
	 2014
	  	 	105.000	% 
	 2015
	  	 	102.500	% 
	 2016 and thereafter
	  	 	100.000	% 

 (d) Reserved. 

(e) Any redemption pursuant to this paragraph 5 shall be made pursuant to the provisions of Sections 3.01 through 3.06 of the Indenture.
Notice of any redemption whether in connection with an Equity Offering or otherwise may be given prior to the completion thereof, and any such redemption or notice may, at the Issuer’s discretion, be subject to one or more conditions precedent
(including, in the case of any Equity Offering, completion thereof ). If any Notes are listed on an exchange, and the rules of such exchange so require, the Issuer shall notify the exchange of any such notice of redemption. In addition, the Issuer
shall notify the exchange of any principal amount of any Notes outstanding following any partial redemption of Notes. 
 6. Mandatory
Redemption. The Issuer shall not be required to make mandatory redemption or sinking fund payments with respect to the Notes. 

  
 A-5 

 7. Notice of Redemption. Subject to Section 3.03 of the Indenture, notice of
redemption will be delivered electronically or mailed by first-class mail at least 30 days but not more than 60 days before the Redemption Date (except that redemption notices may be delivered electronically or mailed more than 60 days prior to a
Redemption Date if the notice is issued in connection with Article 8 or Article 11 of the Indenture) to each Holder whose Notes are to be redeemed at its registered address. No Notes of less than $2,000 can be redeemed or purchased in part, except
that if all the Notes of a Holder are to be redeemed or purchased, the entire amount of Notes held by such Holder even if not in a principal amount of at least $2,000 or an integral multiple thereof, shall be redeemed or purchased. On and after the
Redemption Date, interest ceases to accrue on this Note or portions thereof called for redemption. 
 8. Offers to Repurchase. Upon
the occurrence of a Change of Control, the Issuer shall make a Change of Control Offer in accordance with Section 4.14 of the Indenture. In connection with certain Asset Sales, the Issuer shall make an Asset Sale Offer as and when provided in
accordance with Sections 3.09 and 4.10 of the Indenture. 
 9. Denominations, Transfer, Exchange. The Notes are in registered form
without coupons in denominations of $2,000 and any integral multiple of $1,000 in excess of $2,000. The transfer of Notes may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder,
among other things, to furnish appropriate endorsements and transfer documents and the Issuer may require a Holder to pay any taxes and fees required by law or permitted by the Indenture. The Issuer need not exchange or register the transfer of any
Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part. Also, the Issuer need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to
be redeemed. 
 10. Persons Deemed Owners. The registered Holder of a Note may be treated as its owner for all purposes. 

11. Amendment, Supplement and Waiver. The Indenture, the Guarantees or the Notes may be amended or supplemented as provided in the
Indenture. 
 12. Defaults and Remedies. The Events of Default relating to the Notes are defined in Section 6.01 of the
Indenture. If any Event of Default occurs and is continuing, the Trustee or the Holders of at least 25.0% in principal amount of the then outstanding Notes by notice to the Issuer and the Trustee, in either case specifying in such notice the
respective Event of Default and that such notice is a “notice of acceleration” may declare the principal, premium, if any, interest and any other monetary obligations on all the then outstanding Notes to be due and payable immediately.
Notwithstanding the foregoing, in the case of an Event of Default arising from certain events of bankruptcy or insolvency, all outstanding Notes will become due and payable immediately without further action or notice. Holders may not enforce the
Indenture, the Notes or the Guarantees except as provided in the Indenture. Subject to certain limitations, Holders of a majority in aggregate principal amount of the then outstanding Notes may direct the Trustee in its exercise of any trust or
power. The Trustee may withhold from Holders notice of any continuing Default (except a Default relating to the payment of principal, premium, if any, or interest) if it determines that withholding notice is in their interest. The

  
 A-6 

 
Holders of a majority in aggregate principal amount of the Notes then outstanding by notice to the Trustee (with a copy to the Issuer, provided that any waiver or rescission under
Section 6.04 of the Indenture shall be valid and binding notwithstanding the failure to provide a copy of such notice to the Issuer) may on behalf of all the Holders waive any existing default or and its consequences under the Indenture (except
a continuing Default in payment of the principal of, premium, if any, or interest on any of the Notes held by a non-consenting Holder) (including in connection with an Asset Sale Offer or a change of Control Offer) and rescind any acceleration with
respect to the Notes and its consequences (except if such rescission would conflict with any judgment of a court of competent jurisdiction). The Issuer is required to deliver to the Trustee annually a statement regarding compliance with the
Indenture, and the Issuer is required within fifteen days after becoming aware of any Default, to deliver to the Trustee a statement specifying such Default and what action the Issuer proposes to take with respect thereto. 

13 Authentication. This Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose until
authenticated by the manual signature of the Trustee. 
 14. Reserved. 

15. Governing Law. THE LAWS OF THE STATE OF NEW YORK SHALL, GOVERN AND BE USED TO CONSTRUE THE INDENTURE, THE NOTES AND THE GUARANTEES.

 16. CUSIP and ISIN Numbers. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
Procedures, the issuer has caused CUSIP and ISIN numbers to be printed on the Notes and the Trustee may use CUSIP and ISIN numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers
either as printed on the Notes or as contained in any notice of redemption and reliance may be placed only on the other identification numbers placed thereon. 

The Issuer will furnish to any Holder upon written request and without charge a copy of the Indenture. Requests may be made to the Issuer at
the following address: 
 inVentiv Health, Inc. 

1 Van De Graaff Drive 

Burlington, Massachusetts 01803 

Facsimile: 732-5374999 

Attention: Chief Financial Officer 

  
 A-7 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

					
	(I) or (we) assign and transfer this Note to:            	 	  
	  	
	                                    
                                  (Insert assignee’s legal name)
	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  

	  

	  

	(Print or type assignee’s name, address and zip code)

					
	and irrevocably appoint	 	
	to transfer this Note on the books of the Issuer. The agent may substitute another to act for him.

  

			
	 Date:
	 	  

 

			
	Your Signature:	 	  

		 	(Sign exactly as your name appears on the face of this Note)

  

			
		
	Signature Guarantee*:	 	  

  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

  
 A-8 

 OPTION OF HOLDER TO ELECT PURCHASE 

If you want to elect to have this Note purchased by the Issuer pursuant to Section 4.10 or 4.14 of the Indenture, check the appropriate
box below: 
  

							
	[    ]	 	Section 4.10	 	[    ]	 	Section 4.14

 If you want to elect to have only part of this Note purchased by the Issuer pursuant to Section 4.10 or
Section 4.14 of the Indenture, state the amount you elect to have purchased: 
 $         

 

			
	 Date:
	 	  

 

							
		 	Your Signature:	 	  

		 		 	(Sign exactly your name appears on the face of this Note)
	Signature Guarantee*:	 	  
	  	

  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

  
 A-9 

 EXHIBIT B 

FORM OF CERTIFICATE OF TRANSFER 
  

			
	inVentiv Health, Inc.
	One Van De Graaff Drive
	Burlington, MA 01803
	Facsimile:	 	781-425-4613
	Attention:	 	General Counsel
	
	 inVentiv Health, Inc.
 c/o Thomas H.
Lee Partners LLP

	100 Federal Street
	Boston, MA 02110
	Facsimile:	 	617 227 3514
	Attention:	 	Todd Abbrecht
	
	Wilmington Trust, National Association
	Corporate Capital Markets
	50 South Sixth Street
	Suite 1290
	Minneapolis, MN 55402
	Facsimile:	 	612-217-5651
	Attention:	 	inVentiv Health, Inc. Administrator

  

	 	Re:	10% Senior Notes Due 2018 

 Reference is hereby made to the Indenture, dated as of
August 4, 2010 (the “Indenture”), among inVentiv Health, Inc., the Guarantors named therein and the Trustee. Capitalized terms used but not defined herein shall have the meanings given to them in the Indenture. 

                     (the
“Transferor”) owns and proposes to transfer the Note[s] or interest in such Note[s] specified in Annex A hereto, in the principal amount of $         in such Note[s] or interests (the
“Transfer”), to (the “Transferee”), as further specified in Annex A hereto. In connection with the Transfer, the Transferor hereby certifies that: 

[CHECK ALL THAT APPLY] 
 1.
[    ] CHECK IF TRANSFEREE WILL TAKE DELIVERY OF A BENEFICIAL INTEREST IN THE RELEVANT 144A GLOBAL NOTE OR RELEVANT DEFINITIVE NOTE PURSUANT TO RULE 144A. The Transfer is being effected pursuant to and in accordance with Rule
144A under the United States Securities Act of 1933, as amended (the “Securities Act”), and, accordingly, the Transferor hereby further certifies that the beneficial interest or Definitive Note is being transferred to a Person that
the Transferor reasonably believes is purchasing the beneficial interest or Definitive Note for its own account, 

  
 B-1 

 
or for one or more accounts with respect to which such Person exercises sole investment discretion, and such Person and each such account is a “qualified institutional buyer” within the
meaning of Rule 144A in a transaction meeting the requirements of Rule 144A and such Transfer is in compliance with any applicable blue sky securities laws of any state of the United States. 

2. [    ] CHECK IF TRANSFEREE WILL TAKE DELIVERY OF A BENEFICIAL INTEREST IN THE RELEVANT REGULATION S GLOBAL NOTE OR
RELEVANT DEFINITIVE NOTE PURSUANT TO REGULATION S. The Transfer is being effected pursuant to and in accordance with Rule 903 or Rule 904 and, accordingly, the Transferor hereby further certifies that (i) the Transfer is not being made to a
person in the United States and (x) at the time the buy order was originated, the Transferee was outside the United States or such Transferor and any Person acting on its behalf reasonably believed and believes that the Transferee was outside
the United States or (y) the transaction was executed in, on or through the facilities of a designated offshore securities market and neither such Transferor nor any Person acting on its behalf knows that the transaction was prearranged with a
buyer in the United States, (ii) no directed selling efforts have been made in contravention of the requirements of Rule 903(b) or Rule 904(b) of Regulation S, (iii) the transaction is not part of a plan or scheme to evade the registration
requirements of the Securities Act and (iv) if the proposed transfer is being made prior to the expiration of the applicable Restricted Period, the transfer is not being made to a U.S. Person or for the account or benefit of a U.S. Person
(other than an Initial Purchaser). Upon consummation of the proposed transfer in accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will be subject to the restrictions on Transfer enumerated in the
Indenture and the Securities Act. 
 3. [    ] CHECK AND COMPLETE IF TRANSFEREE WILL TAKE DELIVERY OF A RELEVANT
DEFINITIVE NOTE PURSUANT TO ANY PROVISION OF THE SECURITIES ACT OTHER THAN RULE 144A OR REGULATION S. The Transfer is being effected in compliance with the transfer restrictions applicable to beneficial interests in Restricted Global Notes and
Restricted Definitive Notes and pursuant to and in accordance with the Securities Act and any applicable blue sky securities laws of any state of the United States, and accordingly the Transferor hereby further certifies that (check one): 

(a) [    ] such Transfer is being effected pursuant to and in accordance with Rule 144 under the Securities
Act; or 
 (b) [    ] such Transfer is being effected to the Issuer or a subsidiary thereof; or 

(c) [    ] such Transfer is being made to an “accredited investor” (as defined in Rule 501 of the
Securities Act) that has furnished to the Trustee a signed letter containing certain representations and agreements in form attached as Annex B hereto; or 

(d) [    ] such Transfer is being effected pursuant to an effective registration statement under the
Securities Act and in compliance with the prospectus delivery requirements of the Securities Act. 

  
 B-2 

 4. [    ] CHECK IF TRANSFEREE WILL TAKE DELIVERY OF A BENEFICIAL INTEREST IN
AN UNRESTRICTED GLOBAL NOTE OR OF AN UNRESTRICTED DEFINITIVE NOTE. 
 (a) [    ] CHECK IF TRANSFER IS PURSUANT TO RULE
144. (i) The Transfer is being effected pursuant to and in accordance with Rule 144 under the Securities Act and in compliance with the transfer restrictions contained in the Indenture and any applicable blue sky securities laws of any state of
the United States and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act. Upon consummation of the proposed Transfer in
accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will no longer be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the Restricted Global Notes, on
Restricted Definitive Notes and in the Indenture. 
 (b) [    ] CHECK IF TRANSFER IS PURSUANT TO REGULATION S.
(i) The Transfer is being effected pursuant to and in accordance with Rule 903 or Rule 904 and in compliance with the transfer restrictions contained in the Indenture and any applicable blue sky securities laws of any state of the United States
and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act. Upon consummation of the proposed Transfer in accordance with the terms
of the Indenture, the transferred beneficial interest or Definitive Note will no longer be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the Restricted Global Notes, on Restricted Definitive Notes and
in the Indenture. 
 (c) [    ] CHECK IF TRANSFER IS PURSUANT TO OTHER EXEMPTION. (i) The Transfer is being
effected pursuant to and in compliance with an exemption from the registration requirements of the Securities Act other than Rule 144, Rule 903 or Rule 904 and in compliance with the transfer restrictions contained in the Indenture and any
applicable blue sky securities laws of any State of the United States and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act.
Upon consummation of the proposed Transfer in accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will not be subject to the restrictions on transfer enumerated in the Private Placement Legend printed
on the Restricted Global Notes or Restricted Definitive Notes and in the Indenture. 
 This certificate and the statements contained herein
are made for your benefit and the benefit of the Issuer. 
  

					
	[Insert Name of Transferor]
		
	By:	 	  

		 	Name:	 	
		 	Title:	 	

  
 B-3 

 Dated:
                     
 ANNEX A TO
CERTIFICATE OF TRANSFER 
  

	1.	The Transferor owns and proposes to transfer the following: 

 [CHECK ONE OF (a) OR (b)]

 (a) [    ] a beneficial interest in the: 

 

	 	(i)	[    ] 144A Global Note ([CUSIP:         ]), or 

  

	 	(ii)	[    ] Regulation S Global Note ([CUSIP:         ]), or 

(b) [    ] a Restricted Definitive Note. 
  

	2.	After the Transfer the Transferee will hold: 

 [CHECK ONE] 

(a) [    ] a beneficial interest in the: 
  

	 	(i)	[    ] 144A Global Note ([CUSIP:         ]), or 

  

	 	(ii)	[    ] Regulation S Global Note ([CUSIP:         ]) or 

  

	 	(iii)	[    ] Unrestricted Global Note ([        ] [        ]); or 

(b) [    ] a Restricted Definitive Note; or 

(c) [    ] an Unrestricted Definitive Note, in accordance with the terms of the Indenture. 

  
 B-4 

 ANNEX B TO CERTIFICATE OF TRANSFER 

TRANSFEREE LETTER OF REPRESENTATION 
  

			
	inVentiv Health, Inc.
	One Van De Graaff Drive
	Burlington, MA 01803
	Facsimile:	 	781-425-4613
	Attention:	 	General Counsel
	
	 inVentiv Health, Inc.
 c/o Thomas H.
Lee Partners LLP

	100 Federal Street
	Boston, MA 02110
	Facsimile:	 	617 227 3514
	Attention:	 	Todd Abbrecht
	
	Wilmington Trust, National Association
	
	Corporate Capital Markets
	
	50 South Sixth Street
	
	Suite 1290
	
	Minneapolis, MN 55402
	Facsimile:	 	612-217-5651
	Attention:	 	inVentiv Health, Inc. Administrator

 Ladies and Gentlemen: 

THIS CERTIFICATE IS DELIVERED TO REQUEST A TRANSFER OF $[        ] PRINCIPAL AMOUNT OF THE 10% SENIOR
NOTES DUE 2018 (THE “NOTES”) OF INVENTIV HEALTH, INC. (THE “ISSUER”). 
 Upon transfer, the Notes would be registered in
the name of the new beneficial owner as follows: 
  

			
	Name:	 	  

	Address:	 	  

			
	Taxpayer ID Number:	 	  

 The undersigned represents and warrants to you that: 

(1) We are an “accredited investor” (as defined in Rule 501(a) under the Securities Act of 1933, as amended (the “Securities
Act”)), purchasing for our own account or 

  
 B-5 

 
for the account of such an “accredited investor” at least $100,000 principal amount of the Notes, and we are acquiring the Notes not with a view to, or for offer or sale in connection
with, any distribution in violation of the Securities Act. We have such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of our investment in the Notes, and we invest in or purchase
securities similar to the Notes in the normal course of our business. We, and any accounts for which we are acting, are each able to bear the economic risk of our or its investment. 

(2) We understand that the Notes have not been registered under the Securities Act and, unless so registered, may not be sold except as
permitted in the following sentence. We agree on our own behalf and on behalf of any investor account for which we are purchasing Notes to offer, sell or otherwise transfer such Notes prior to the date that is one year after the later of the date of
original issue and the last date on which either the Issuer or any affiliate of such Issuer was the owner of such Notes (or any predecessor thereto) (the “Resale Restriction Termination Date”) only (a) in the United States to a person
whom we reasonably believe is a qualified institutional buyer (as defined in rule 144A under the Securities Act) in a transaction meeting the requirements of Rule 144A, (b) outside the United States in an offshore transaction in accordance with
Rule 904 of Regulation S under the Securities Act, (c) pursuant to an exemption from registration under the Securities Act provided by Rule 144 thereunder (if applicable), (d) pursuant to an effective registration statement under the
Securities Act, or (e) to an “accredited investor” in accordance with the requirements below, in each of cases (a) through (d) in accordance with any applicable securities laws of any state of the United States. In addition,
we will, and each subsequent holder is required to, notify any purchaser of the Security evidenced hereby of the resale restrictions set forth above. The foregoing restrictions on resale will not apply subsequent to the Resale Restriction
Termination Date. If any resale or other transfer of the Notes is proposed to be made to an “accredited investor” prior to the Resale Restriction Termination Date, the transferor shall deliver a letter from the transferee substantially in
the form of this letter to the Issuer and Wilmington Trust, National Association, in its capacity as trustee in respect of the Notes (the “Trustee”) which shall provide, among other things, that the transferee is an “accredited
investor” within the meaning of Rule 501(a)(1), (2), (3), (5) or (7) under the Securities Act and that it is acquiring such Notes for investment purposes and not for distribution in violation of the Securities Act. Each purchaser
acknowledges that the Issuer and the Trustee reserve the right prior to the offer, sale or other transfer prior to the Resale Restriction Termination Date of the Notes pursuant to clause 2(b), 2(c), 2(d) or 2(e) above to require the delivery of an
opinion of counsel, certifications or other information satisfactory to the Issuer and the Trustee. 
  

			
	Dated:	 	  

 

					
	TRANSFEREE:	 	  
	 	,

  

					
	By:	 	  
	 	

  
 B-6

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