Document:

EX-10.16

 Exhibit 10.16 
 REGADO BIOSCIENCES, INC. 
 December 22, 2008 

Steven L. Zelenkofske, D.O. 
 Dear
Dr. Zelenkofske: 
 The following amendment to your employment agreement dated November 19, 2008 (the “Agreement”) is
intended to comply with Section 409A of the Internal Revenue Code of 1986, as amended. 
 This letter agreement amends the Agreement by
deleting the first sentence in the seventh bullet point and replacing it with the following: 
 In the even your employment is
terminated by the Company (or its subsidiary) without cause (as defined below), (A) you will receive payments equal to the sum of twelve (12) months of salary and the target bonus (less taxes and authorized deductions), to be paid
bimonthly in accordance with the Company’s customary payroll practices, commencing sixty (60) days following such termination of employment (the “Severance Payments”); and (B) if you then participate in the Company’s
(or its subsidiary’s) medical and/or dental plans and you timely elect to continue and maintain group health plan coverage pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended, the Company (or its subsidiary) will
pay monthly on your behalf a portion of the cost of such coverage for the twelve (12) months after the date of your termination, which payments will be equal to the amount of the monthly premium for such coverage, less the amount that you would
have been required to pay if you had remained an active employee of the Company. Each of the Severance Payments shall be treated as a separate payment for purposes of Code Section 409A. 
 Your entitlement to Severance Payments under the Agreement continues to be subject to your execution of a separation agreement and general release within the time period specified in the Agreement.

 This Agreement is the further amended by adding the following paragraph at the end: 

This letter agreement is intended to comply with the requirements of Code Section 409A and regulations promulgated thereunder. To the
extent that any provision in this letter agreement is ambiguous as to its compliance with Code Section 409A, the provision shall be read in such a manner so that no payments due under this letter agreement shall be subject to an
“additional tax” as defined in Code Section 409A(a)(1)(B). In no event may you, directly or indirectly, designate the calendar year of payment. All reimbursements provided under this letter agreement shall be made or provided in
accordance with the requirements of Code Section 409A, including, where applicable, the requirement that (i) any reimbursement is for expenses incurred during your lifetime (or during a shorter period of time specified in this letter
agreement), (ii) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or
before the last day of the calendar year following the year in which the expense is incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange for another benefit. Notwithstanding anything contained herein to the
contrary, you shall not be considered to have terminated employment with the Company for purposes of the fifth bullet point hereof, unless you would be considered to have incurred a “termination of employment” from the Company within the
meaning of Treasury Regulation §1.409A-1(h)(1)(ii). 

 Please indicate your acceptance of the amendment to the Agreement by signing this letter where indicated
below. 
  

	
	Sincerely,
	
	 /s/ Chris Courts

	
	Chris Courts
	Vice-President of Finance
	

  

									
	ACCEPTED:	 	 /s/ Steven L. Zelenkofske        
	 		 	DATE:	 	 12/22/08

		 	Steven L. Zelenkofske, D.O.EX-10.18

 Exhibit 10.18 

 
 

 
 November 29, 2008 
 Ms. Ellen McDonald 
 Dear Ms. McDonald: 

In follow-up to our recent discussions, I am pleased to offer you the position of Senior Vice President, Business Operations and Chief Business Officer
of Regado Biosciences, Inc. (the “Company”). In this role, you will report to the Company’s President and CEO, David J. Mazzo, Ph.D, and your effective start date will be Monday, December 1, 2008. 

The key terms and conditions of your employment by the Company are listed below: 

 

	 	•	 	 A gross salary of $23,333.33 monthly (less taxes and authorized deductions) consistent with the Company’s normal payroll practices, which computes
to $280,000.00 over a twelve-month period. Typically, employees are paid on the 15th and the last business day of the month. 

  

	 	•	 	 You will be eligible to participate in the Company’s Equity Compensation Plan and, subject to the formal approval of the Company’s Board of
Directors, will be granted 435,000 options effective your
1st day of employment. 

These options will have a per share exercise price equal to the fair market value per share of the Company’s Common Stock as of the
date of grant, and valued in accordance with the guidance set forth under Section 409A of the Internal Revenue Code. These options will be granted on the first day of employment with the Company; hence, their price will be fixed on that day in
accordance with applicable IRS and SEC practices. These options will vest and become exercisable from time to time, subject to the following schedule, which will be set forth in the option agreement: one-quarter will vest on the first anniversary of
the date of your initial employment with the remainder vesting in equal monthly installments thereafter for the succeeding three (3) years; provided, however, these shares will vest and will become exercisable immediately upon a Change of
Control or upon a Corporate Reorganization, each of which, as well as all other terms applicable to the options as discussed above, will be set forth in the option agreement. Additional option shares may be awarded by the Company’s Board of
Directors from time to time as determined by the Company’s Board of Directors. 
  

	 	•	 	 You will be eligible for a target bonus of 35% of your annual salary based upon the Company’s achievement of corporate objectives, as well as
achievement of your individual objectives as determined by the Company’s Chief Executive Officer. Your bonus eligibility will commence with the 2009 calendar year as your first full year of employment. In order to be eligible to receive a bonus
payment, you must be in an active working status with the Company (or its subsidiary) at the time of such payment. Each such bonus that relates to a particular calendar year, to the extent earned, will be paid no later than March 15th of the year following such calendar year.

  

					
	318 Blackwell Street, Suite 130	 	Phone:    (919) 287-9428	 	www.regadobio.com
	Durham, NC 27701	 	Fax:        (919) 287-9430	 	

	 	•	 	 You will receive four (4) weeks of paid vacation per year commencing in January 2009. 

 

	 	•	 	 The Company will reimburse your reasonable business expenses in accordance with the Company’s business expense policy.

  

	 	•	 	 In the event your employment is terminated by the Company without cause (as defined below), (A) you will receive payments equal to the sum of
twelve (12) months of salary (less taxes and authorized deductions), to be paid bimonthly in accordance with the Company’s customary payroll practices, commencing immediately following the earlier of (i) the effectiveness of the
release of claims discussed below and (ii) the Company’s failure to provide a reasonably acceptable form within 3 days following such termination of employment as discussed below (the “ Severance Payments”); provided, that if
such termination of employment occurs on or after October 10th of any year, the Severance Payments shall commence no earlier than January 1st of the following year; and (B) if you then participate in the Company’s medical and/or dental plans and you
timely elect to continue and maintain group health plan coverage pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended, the Company will pay monthly on your behalf a portion of the cost such coverage for the twelve
(12) months after the date of your termination, which payments will be equal to the amount of the monthly premium for such coverage less the amount that you would have been required to pay if you had remained an active employee of the Company.
As used in this letter, “cause” will be defined as: (i) a material act or act of fraud committed by you that is intended to result in your personal enrichment to the detriment or at the expense of the Company; (ii) you are
convicted of a felony; (iii) gross negligence or willful misconduct by you, or failure by you to perform the duties or obligations reasonably assigned to you by the Company’s Board of Directors or Chief Executive Officer from time to time,
which is not cured upon ten (10) days prior written notice (unless such negligence, misconduct or failure is not susceptible of a cure); or (iv) you violate the Company’s Proprietary Information, Inventions and Noncompetition
Agreement signed in conjunction with this letter as described below. In the event of any termination of this letter for any reason other than a termination by the Company without cause, the Company will have no obligation or liability with respect
to any obligations described above. The Company may terminate your employment at any time. 

  

	 	•	 	 You and your family members will be eligible for the Company’s benefit plans as of the 1st day of your employment. Insurance benefits include medical, dental, disability, life and vision, and additional
programs are available for flexible spending accounts and 401k. All corporate benefit programs are fully subsidized by the Company. 

  

	 	•	 	 You will be responsible for all taxes assessed against you with respect to the compensation and benefits described in this letter, and the Company
makes no representations as to the tax treatment of such compensation and benefits. To the extent permitted under applicable regulations and/or other guidance of general applicability issued pursuant to Section 409A of the Internal Revenue Code
of 1986, as amended (the “Code”), the Company reserves the right to modify this letter to conform with any or all relevant provisions regarding compensation and/or benefits so that such compensation

  

					
	318 Blackwell Street, Suite 130	 	Phone:    (919) 287-9428	 	www.regadobio.com
	Durham, NC 27701	 	Fax:        (919) 287-9430	 	

  
 2 

	 	 
and benefits are exempt from the provisions of Code Section 409A and/or otherwise comply with such provisions so as to avoid the tax consequences set forth in Code Section 409A(a)(1).
Notwithstanding, to the extent the Company determines that you are a “specified employee” to whom Code Section 409A(a)(2)(B)(i) applies with respect to any of the compensation and/or benefits described above, the Company will delay
the payment of such compensation and/or the provision of such benefits until the date that is six (6) months after the date of your separation from service (within the meaning of section 409A of the Code). 

 

	 	•	 	 In order to receive the Severance Payments, you must timely execute a separation agreement and general release in a customary form as is determined to
be reasonably necessary by the Company in its good faith and reasonable discretion. Notwithstanding anything to the contrary contained in this letter, the Company’s obligations to provide you with any severance will immediately cease if you
breach any of the provisions of the Company’s Proprietary Information, Inventions and Noncompetition Agreement or any other agreement you have with the Company, or if any provision of those agreements is determined to be unenforceable, to any
extent, by a court or arbitration panel, whether by preliminary or final adjudication. 

  

	 	•	 	 You represent that you continue to be free to accept employment with the Company without any contractual restrictions, express or implied, with respect
to any of your prior employers and/or positions, and you understand that continued employment at the Company are contingent on the accuracy of this representation. 

 

	 	•	 	 You agree to be bound by and to comply fully with all Company policies and procedures for employees, including but not limited to, all terms and
conditions set forth in the Company’s employee handbook, compliance manual and any other memoranda and communications applicable to you pertaining to policies, procedures, rules and regulations, as currently in effect and as may be amended from
time to time. These policies and procedures include, among other things and without limitation, your obligations to comply with Company rules regarding confidential and proprietary information and trade secrets, and to furnish accurate and complete
information to the Company in connection with your employment. 

  

	 	•	 	 You will be eligible to participate in the Regado Supplemental Incentive Program once the Board of Directors formalizes the details of said plan. This
plan will be designed to provide an additional bonus upon achievement of success of the Company’s business plan. The program will be restricted to select members of the management team and, as such, is considered confidential. You will be
provided with details of the plan as soon as they are finalized. 

 This letter will be binding upon any successor (whether
direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all of the business and/or assets of the Company. This letter will also be binding upon, inure to the benefit of and be enforceable by the parties hereto
and their successors and assigns. You may not assign or otherwise transfer any of your rights or interests in this letter without the prior written agreement of the Company. Upon assignment by the Company to a successor, all of the rights and
obligations of the parties under this letter will remain in effect except that the rights and obligations of the Company will become rights and obligations of the successor (and references herein to the Company will refer instead to the successor).

  

					
	318 Blackwell Street, Suite 130	 	Phone:    (919) 287-9428	 	www.regadobio.com
	Durham, NC 27701	 	Fax:        (919) 287-9430	 	

  
 3 

 Nothing in this letter is intended to create a fixed term of employment at the Company or to guarantee your
employment with the Company. Your employment with the Company is on an at will basis, meaning that the Company will be free to terminate your employment at any time, with or without cause and with or without notice, and that you will be free to
terminate your employment at any time. 
 Prior to initiating employment, you will be required to sign the Company’s Proprietary
Information, Inventions and Noncompetition Agreement, which will preclude your employment by, or active participation in, any competitor of the Company for up to one (1) year after termination of employment with the Company. Furthermore, in
compliance with the Immigration Reform and Control Act of 1986, each new employee, as a condition of employment, must complete an Employment Verification Form I-9 and present proof of identity and employment eligibility. Please plan to bring the
necessary documentation on your first day of work. 
 On behalf of the Company, I trust you will find these terms of employment acceptable and
look forward to having you as a valued member of the Company’s team. Kindly indicate your acceptance of this offer by signing and returning to the address below. 
 Thank you for your keen interest in the Company. All of us at Regado are excited about you joining our team and look forward to working with you in the near future. 

 

	
	Sincerely,
	
	 /s/ Chris Courts
  

	Chris Courts, CPA
	Vice-President of Finance

  

									
	ACCEPTED:	 	/s/ Ellen McDonald	 		 	DATE:	 	 12/1/08

		 	Ellen McDonald	 		 		 	

  

					
	318 Blackwell Street, Suite 130	 	Phone:    (919) 287-9428	 	www.regadobio.com
	Durham, NC 27701	 	Fax:        (919) 287-9430	 	

  
 4

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