Document:

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                                                                Exhibit 10.16(C)

                               THIRD AMENDMENT TO
               AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

         THIS THIRD AMENDMENT TO AMENDED AND RESTATED REGISTRATION RIGHTS
AGREEMENT (this "THIRD AMENDMENT"), is dated November 18, 2003, by and among
Animas Corporation, a Delaware corporation (the "COMPANY"), Johnson and Johnson
Development Corporation ("JJDC"), and those Existing Holders (as defined below)
listed on the signature page hereto.

         WHEREAS, the Company and certain holders of (a) the Company's Series B
Convertible Preferred Stock, $0.01 par value per share (the "SERIES B PREFERRED
STOCK") and (b) the Company's Series C Convertible Preferred Stock, $0.01 par
value per share (the "SERIES C PREFERRED STOCK"), are parties to an Amended and
Restated Registration Rights Agreement dated as of October 11, 2001, as amended
by that certain First Amendment to Amended and Restated Registration Rights
Agreement dated as of May 13, 2002, and as amended by that certain Second
Amendment to Amended and Restated Registration Rights Agreement dated as of
January 21, 2003 (together with all joinders thereto, the "REGISTRATION RIGHTS
AGREEMENT"); and

         WHEREAS, concurrently with the execution of this Third Amendment, JJDC
is acquiring from the Company units (the "UNITS") consisting of one share of
Series C Preferred Stock and one warrant to purchase nine-tenths (0.9) of one
share of Series C Preferred Stock (the "WARRANTS"), pursuant to a Unit Purchase
Agreement (the "PURCHASE AGREEMENT"); and

         WHEREAS, the sale to JJDC has been deemed to be a Strategic Investor
Offering (as defined in the Stockholders Consent) by the Board of Directors of
the Company in accordance with the terms of the Unanimous Consent of
Stockholders of the Company dated as of January 21, 2003 (the "STOCKHOLDERS
CONSENT"); and

         WHEREAS, in the Stockholders Consent, each of the holders of the
Company's Series B Preferred Stock, and each of the holders of the Company's
Series C Preferred Stock as of the date of the Stockholders Consent
(collectively, the "CONSENTING Holders"), empowered the Chairman, President and
Chief Executive Officer, Chief Financial Officer, the Senior Vice President and
any Vice President of the Company (each an "AUTHORIZED OFFICER," and
collectively, the "AUTHORIZED OFFICERS") as their attorney-in fact, in their
name and on their behalf, to execute and deliver from time to time all documents
which are reasonably necessary to effectuate amendments to the Registration
Rights Agreement so that the Common Stock issued or otherwise issuable as a
result of any Strategic Investor Offering could be afforded the same
registration rights as currently set forth in the Registration Rights Agreement
(the "POWER OF ATTORNEY"); and

         WHEREAS, as a condition to entering into and consummating the Purchase
Agreement, JJDC has required the Company to amend the Registration Rights
Agreement in order to, among other things, include the Common Stock received
upon conversion of the Series C Preferred Stock included in the Units (including
conversion of the Series C Preferred Stock received upon exercise of the
Warrants included in the Units) as "Registrable Securities" within the meaning
of the Registration Rights Agreement; and

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         WHEREAS, to induce JJDC to enter into and consummate the Purchase
Agreement, the Company desires to amend the Registration Rights Agreement on the
terms and conditions set forth below; and

         WHEREAS, Section 13(d) of the Registration Rights Agreement provides
that the Registration Rights Agreement may not be amended or modified, and no
provision thereof may be waived, without the consent of (i) the Company, (ii)
the Initial Series B Investors holding at least 60% of the votes entitled to be
cast by the holders of Series B Conversion Shares owned by all such Initial
Series B Investors, solely with respect to such Series B Conversion Shares,
(iii) the Initial Series C Investors holding at least 60% of the votes entitled
to be cast by the holders of Series C Conversion Shares owned by all such
Initial Series C Investors, solely with respect to such Series C Conversion
Shares, and (iv) the holders of a majority of the votes entitled to be cast by
the holders of the Registrable Securities then outstanding (collectively, the
"REQUIRED APPROVALS").

         NOW, THEREFORE, in consideration of the premises, the agreements and
mutual covenants set forth herein, and for other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the
parties hereto, intending to be legally bound hereby, do hereby agree as
follows:

         1.       Defined Terms. Capitalized terms used but not otherwise
defined herein have the respective meanings ascribed to such terms in the
Registration Rights Agreement.

         2.       Amendments to Registration Rights Agreement.

                  a.       The following defined terms are hereby amended and
restated in their entirety as follows:

                           (1)      "Existing Holders" means those holders of
the Company's Series B Preferred Stock and those holders of the Company's Series
C Preferred Stock, in each case who are a party to this Registration Rights
Agreement.

                           (2)      "Series C Investor" shall mean,
collectively, (A) the purchasers of Series C Preferred Stock pursuant to the
Series C Purchase Agreement, including the Additional Series C Investors (as
defined in the First Amendment), (B) the purchasers of Units pursuant to any
Unit Purchase Agreement, and (C) Silicon Valley Bank.

                           (3)      "Series C Preferred Stock" shall mean,
collectively, (i) the shares of Series C Preferred Stock issued pursuant to the
Series C Purchase Agreement, whether at the Initial Closing or at a Subsequent
Closing (and including the Additional Series C Preferred Stock), and (ii) any
shares of Series C Preferred Stock purchased pursuant to or in connection with a
Unit Purchase Agreement (including but not limited to those shares issued upon
exercise of the Warrants).

                           (4)      "Unit Purchase Agreement" shall mean (A)
that certain Unit Purchase Agreement dated January 21, 2003 (together with all
joinders thereto, including but not limited to that Unit Purchase Agreement
dated March 21, 2003 between the Company and InvestCare Partners Limited
Partnership) pursuant to which certain Existing Holders, holders

                                      -2-

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of the Series C Preferred Stock, certain holders of the Common Stock and certain
new investors acquired Units and (B) any Unit Purchase Agreement used in a
Strategic Investor Offering (as defined in the Stockholders Consent) whereby a
strategic investor acquires Units in the Company.

                           (5)      "Units" shall mean those certain Units
purchased pursuant to a Unit Purchase Agreement and consisting of one share of
Series C Preferred Stock and a Warrant.

         3.       Additional Parties. The Company, together with each Consenting
Holder, without any further action on their respective parts, hereby consents to
the inclusion of the Common Stock received directly or upon conversion of any
convertible securities included in a Strategic Investor Offering as Registrable
Securities, on substantially the terms and conditions applicable to other
Registrable Securities pursuant to the Registration Rights Agreement.

         4.       Ratification of Registration Rights Agreement. Except as
expressly amended hereby, all of the terms of the Registration Rights Agreement
shall remain in full force and effect and are hereby ratified and confirmed.

         5.       Governing Law. This Third Amendment and all questions relating
to its validity, interpretation, performance and enforcement shall be governed
and construed in accordance with the laws of the Commonwealth of Pennsylvania,
notwithstanding any conflict of laws doctrines of such Commonwealth or any other
jurisdiction to the contrary.

         6.       Counterparts; Facsimile Execution. This Third Amendment may be
executed in any number of counterparts, including by facsimile signature, each
of which shall be an original and all of which, when taken together, shall be
deemed one and the same agreement.

         7.       Effective Time. This Third Amendment shall become effective
and legally binding upon the Company and the Existing Holders and shall be
deemed to effectively amend the Registration Rights Agreement, when one or more
counterparts hereof, individually or taken together, shall bear the signatures
of the Required Approvals.

   THE REMAINDER OF THIS PAGE IS INTENTIONALLY BLANK. SIGNATURE PAGES FOLLOW.

                                      -3-

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                                                                Exhibit 10.16(C)

         IN WITNESS WHEREOF, the parties hereto have executed, or caused this
Third Amendment to Amended and Restated Registration Rights Agreement to be
executed by its duly authorized officer or other representative, on the date and
year first above written.

ANIMAS CORPORATION                       JOHNSON AND JOHNSON DEVELOPMENT
                                         CORPORATION

By: /s/ Katherine D. Crothall            By: /s/ Roger J. Guidi
    ----------------------------             --------------------------
Name:                                    Name: Roger J. Guidi
Title:                                   Title: Vice President

 /s/ Katherine D. Crothall
----------------------------
KATHERINE CROTHALL, PRESIDENT
AND CHIEF EXECUTIVE OFFICER OF
ANIMAS CORPORATION, SIGNING
PURSUANT TO THE POWER OF
ATTORNEY GRANTED BY:

KATHERINE CROTHALL                       CHRIS COYNE
GRAEME CROTHALL                          GREG COYNE
PETER LARKMANN TRUST                     CITY NATIONAL BANK TTEE FBO
KAREN LARKMANN TRUST                     DWT/PARSONS
CHRISTINE LARKMANN TRUST                 DONALD A. SIVICK, JR
GAYLE LARKMANN TRUST                     DANIEL W. K. NG
GWEN CROTHALL TRUST                      MICHAEL J. MITCHELL
WILLIAM A. GRAHAM, IV                    JOHN C. TOMPKINS
HLM/UH FUND L.P.                         SARA LEE TOMPKINS
HLM OPPORTUNITIES FUND, L.P.             WILLIAM KEANE
HLM/CB FUND II, L.P.                     BURR B. MCKEEHAN
LIBERTY ADVISORS, INC.                   ALAN I. REICH/MINDY M. REICH
LIBERTY VENTURES I, L.P.                 PILGRIM BAXTER HYBRID PARTNERS II, L.P.
LIBERTY VENTURES II, L.P.                DAVID ELLIS
TDH CAPITAL PARTNERS                     MICHAEL MERSON
ANVERS L.P.                              NG ASSOCIATES
ANVERS II L.P.<PAGE>

                                                                   EXHIBIT 10.17

                               ANIMAS CORPORATION

                            INVESTOR RIGHTS AGREEMENT

         This Investor Rights Agreement (this "Agreement") is entered into as of
January 28, 2000, by and among Animas Corporation, a Delaware corporation (the
"Company") and the purchasers of the Company's Series A Preferred Stock ("Series
A Preferred Stock") set forth on Exhibit A of certain Series A Preferred
Subscription Agreements of even date herewith (the "Subscription Agreements")
and Exhibit A hereto. The purchasers of the Series A Preferred Stock shall be
referred to hereinafter as the "Investors" and each individually as an
"Investor."

                                    RECITALS

         WHEREAS, the Company proposes to sell and issue up to 1,920,000 shares
of its Series A Preferred Stock pursuant to the Subscription Agreements; and

         WHEREAS, as a condition of entering into the Subscription Agreements,
the Investors have requested that the Company extend to the rights set forth
below.

         NOW, THEREFORE, in consideration of the mutual promises,
representations, warranties, covenants and conditions set forth in this
Agreement and in the Subscription Agreements, the parties mutually agree as
follows:

1.       GENERAL

         1.1      DEFINITIONS. As used in this Agreement the following terms
shall have the following respective meanings:

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "Form S-3" means such form under the Securities Act as in effect on the
date hereof or any successor registration form under the Securities Act
subsequently adopted by the SEC which permits inclusion or incorporation of
substantial information by reference to other documents filed by the Company
with the SEC.

         "Holder" means any person owning of record Registrable Securities that
have not been sold to the public.

         "Initial Public Offering" means the Company's first firm commitment
underwritten public offering of its Common Stock registered under the Securities
Act.

         "Qualified Public Offering" means an underwritten, firm commitment
public offering registered under the Securities Act covering the offer and sale
by the Company of its Common Stock in which the aggregate gross proceeds to the
Company exceed $15,000,000 and in which the price per share of such Common Stock
equals $15.00 (such

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price subject to equitable adjustment in the event of any stock split, stock
dividend, combination, reorganization, reclassification or other similar event).

         "Register," "Registered," and "Registration" refer to a registration
effected by preparing and filing a registration statement in compliance with the
Securities Act, and the declaration or ordering of effectiveness of such
registration statement or document.

         "Registrable Securities" means (a) Common Stock of the Company issued
or issuable upon conversion of the Shares and (b) any Common Stock of the
Company issued as (or issuable upon the conversion or exercise of any warrant,
right or other security which is issued as) a dividend or other distribution
with respect to, or in exchange for or in replacement of, such above-described
securities. Notwithstanding the foregoing, Registrable Securities shall not
include any securities sold by a person to the public pursuant to a registration
statement or Rule 144.

         "Registrable Securities Then Outstanding" shall be the number of shares
determined by calculating the total number of shares of the Company's Common
Stock that are Registrable Securities and either (a) are then issued and
outstanding or (b) are issuable pursuant to then exercisable or convertible
securities.

         "Registration Expenses" shall mean all expenses incurred by the Company
in complying with Sections 2.2, 2.3 and 2.4 hereof, including, without
limitation, all registration and filing fees, printing expenses, fees and
disbursements of counsel for the Company, reasonable fees and disbursements of a
single special counsel for the Holders, blue sky fees and expenses and the
expense of any special audits incident to or required by any such registration
(but excluding the compensation of regular employees of the Company which shall
be paid in any event by the Company).

         "SEC" or "Commission" means the Securities and Exchange Commission.

         "Securities Act" shall mean the Securities Act of 1933, as amended.

         "Selling Expenses" shall mean all underwriting discounts and selling
commissions applicable to the sale.

         "Shares" shall mean the Company's Series A Preferred Stock issued
pursuant to the Subscription Agreements.

2.       REGISTRATION; RESTRICTIONS ON TRANSFER

         2.1      RESTRICTIONS ON TRANSFER.

                  2.1.1    Each Holder agrees not to make any disposition of all
or any portion of the Shares or Registrable Securities unless and until:

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                           2.1.1.1  There is then in effect a registration
statement under the Securities Act covering such proposed disposition and such
disposition is made in accordance with such registration statement; or

                           2.1.1.2  Such disposition is made pursuant to and in
compliance with Rule 144.

                  2.1.2    Each certificate representing Shares or Registrable
Securities shall (unless otherwise permitted by the provisions of the Agreement)
be stamped or otherwise imprinted with a legend substantially similar to the
following (in addition to any legend required under applicable state securities
laws):

         THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933 (THE "ACT") AND MAY NOT BE OFFERED, SOLD OR
         OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND
         UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN
         OPINION OF COUNSEL OR OTHER EVIDENCE SATISFACTORY TO THE COMPANY AND
         ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

                  2.1.3    The Company shall be obligated to reissue promptly
unlegended certificates at the request of any holder thereof if the holder shall
have obtained an opinion of counsel (which counsel may be counsel to the
Company) reasonably acceptable to the Company to the effect that the securities
proposed to be unlegended may lawfully be so disposed of without registration,
qualification or legend.

                  2.1.4    Any legend endorsed on an instrument pursuant to
applicable state securities laws and the stop-transfer instructions with respect
to such securities shall be removed upon receipt by the Company of an order of
the appropriate blue sky authority authorizing such removal.

         2.2      DEMAND REGISTRATION.

                  2.2.1    Subject to the conditions of this Section 2.2, if the
Company receives a request from the Holders of at least 30% of the Registrable
Securities Then Outstanding (the "Initiating Holders") that the Company register
at least 30% of the Registrable Securities Then Outstanding then the Company
shall, within 15 days of the receipt thereof, give notice of such request to all
Holders, and use its best efforts to effect, as soon as practicable, the
registration of all Registrable Securities that the Holders request to be
registered.

                  2.2.2    If the Initiating Holders intend to distribute the
Registrable Securities by means of an underwriting, they shall so advise the
Company as a part of their demand pursuant to this Section 2.2 or Section 2.4
and the Company shall include such information in the notice referred to in
Section 2.2.1 or Section 2.4.1, as applicable. In such event, the right of any
Holder to include its Registrable Securities in such

<PAGE>

registration shall be conditioned upon participation in such underwriting. The
underwriter or underwriters for such offering shall be selected by a majority in
interest of the Initiating Holders (which underwriter or underwriters shall be
reasonably acceptable to the Company). Notwithstanding any other provision of
this Section 2.2 or Section 2.4, if the underwriter advises the Company that
marketing factors require a limitation of the number of securities to be
underwritten (including Registrable Securities) then the Company shall so advise
all participating Holders, and the number of shares that may be included in the
underwriting and registration shall be allocated pro rata to the participating
Holders based on the number of Registrable Securities held; provided, however,
that the number of shares of Registrable Securities to be included in such
underwriting and registration shall not be reduced unless all other securities
of the Company are first entirely excluded from the underwriting and
registration.

                  2.2.3    The Company shall not be required to effect a
registration pursuant to this Section 2.2:

                           2.2.3.1  prior to the earlier of the (i) third
anniversary of the date hereof or (ii) six months following the effective date
of the registration statement pertaining to the Initial Public Offering;

                           2.2.3.2  after the Company has effected two
registrations pursuant to this Section 2.2, and such registrations have been
declared or ordered effective;

                           2.2.3.3  during the period starting with the date of
filing of, and ending on the date six months following the effective date of a
registration statement pertaining to (i) the Initial Public Offering or (ii) to
any other underwritten public offering made pursuant to this Section 2.2 or
Section 2.4 or in which the Holders were given the opportunity to participate
pursuant to Section 2.3 for not less than 25% of the amount of the offering;
provided that the Company makes reasonable and diligent good faith efforts to
cause such registration statement to become effective;

                           2.2.3.4  if within 15 days of receipt of a written
request from Initiating Holders pursuant to Section 2.2.1, the Company gives
notice to the Holders of the Company's intention to make its Initial Public
Offering within 90 days;

                           2.2.3.5  if the Company shall furnish to the
Initiating Holders a certificate signed by the Chairman of the Board stating
that in the good faith judgment of the Board of Directors, it would be seriously
detrimental to the Company and its stockholders for such registration statement
to be effected at such time, in which event the Company shall have the right to
defer such filing for a period of not more than 90 days after receipt of the
request of the Initiating Holders; provided that such right to delay a request
shall be exercised by the Company not more than once in any twelve month period;

                           2.2.3.6  if the Initiating Holders propose to dispose
of shares of Registrable Securities that may be immediately registered on Form
S-3 pursuant to a request made pursuant to Section 2.4 below; or

<PAGE>

                           2.2.3.7  If the Initiating Holders propose to dispose
of shares of Registrable Securities at an aggregate price to the public of less
than $15,000,000.

         2.3      PIGGYBACK REGISTRATIONS.

                  2.3.1    The Company shall promptly notify all Holders prior
to the filing of any registration statement under the Securities Act for a
public offering of securities of the Company (including, but not limited to,
registration statements relating to secondary offerings of securities of the
Company, but excluding registration statements relating to employee benefit
plans or corporate reorganizations or other transactions under Rule 145 of the
Securities Act) and will afford each such Holder an opportunity to include in
such registration statement all or part of the Registrable Securities held by
such Holder. Each Holder desiring to include Registrable Securities in any such
registration statement shall notify the Company within 10 days after the notice
from the Company. Such notice shall state the intended method of disposition of
the Registrable Securities by such Holder. If a Holder decides not to include
all of its Registrable Securities in any registration statement filed by the
Company, such Holder shall nevertheless continue to have the right to include
any Registrable Securities in any subsequent registration statement or
registration statements as may be filed by the Company, all upon the terms and
conditions set forth herein.

                  2.3.2    UNDERWRITING. If the registration statement under
which the Company gives notice under this Section 2.3 is for an underwritten
offering, the Company shall so advise the Holders. In such event, the right of
any Holder to be included in a registration pursuant to this Section 2.3 shall
be conditioned upon the Holder's participation in the underwriting.
Notwithstanding any other provision of the Agreement, if the underwriter
determines in good faith that marketing factors require a limitation of the
number of shares to be underwritten, the number of shares that may be included
in the underwriting shall be allocated, first, to the Company; second, to the
Holders pro rata based on the total number of Registrable Securities held by the
Holders; and third, to any stockholder of the Company (other than a Holder) on a
pro rata basis.

                  2.3.3    RIGHT TO TERMINATE REGISTRATION. The Company shall
have the right to terminate or withdraw any registration initiated by it under
this Section 2.3 prior to the effectiveness of such registration whether or not
any Holder has elected to include securities in such registration. The
Registration Expenses of such withdrawn registration shall be borne by the
Company in accordance with Section 2.5 hereof.

         2.4      FORM S-3 REGISTRATION.

                  2.4.1    If the Company shall receive from the Holders of at
least 30% of the Registrable Securities a request that the Company effect a
registration on Form S-3 (or any successor to Form S-3) or any similar
short-form registration statement and any related qualification or compliance
with respect to all or a part of the Registrable Securities owned by such Holder
or Holders, the Company will (a) promptly give notice of the proposed
registration, and any related qualification or compliance, to all other Holders
of Registrable Securities and (b) as soon as practicable, effect such
registration

<PAGE>

and all such qualifications and compliances as would permit or facilitate the
sale and distribution of the Registrable Securities specified in such request,
together with the Registrable Securities of any other Holder or Holders joining
in such request by notice to the Company given within 15 days after receipt of
such notice from the Company; provided, however, that the Company shall not be
obligated to effect any such registration, qualification or compliance pursuant
to this Section 2.4:

                           2.4.1.1  if Form S-3 (or any successor or similar
form) is not available for such offering by the Holders;

                           2.4.1.2  if the Holders propose to sell Registrable
Securities at an aggregate price to the public of less than $1,000,000;

                           2.4.1.3  if the Company shall furnish to the Holders
a certificate signed by the Chairman of the Board stating that in the good faith
judgment of the Board of Directors, it would be seriously detrimental to the
Company and its stockholders for such Form S-3 registration to be effected at
such time, in which event the Company shall have the right to defer the filing
of the Form S-3 registration statement for a period of not more than 90 days
after receipt of the request of the Holder or Holders under this Section 2.4;
provided, that such right to delay a request shall be exercised by the Company
not more than once in any twelve month period;

                           2.4.1.4  if the Company has, within the twelve month
period preceding the date of such request, already effected a registration on
Form S-3 for the Holders pursuant to this Section 2.4; or

                           2.4.1.5  in any particular jurisdiction in which the
Company would be required to qualify to do business or to execute a general
consent to service of process in effecting such registration, qualification or
compliance.

                  2.4.2    Subject to the foregoing, the Company shall file a
Form S-3 registration statement covering the Registrable Securities and other
securities so requested to be registered as soon as practicable after receipt of
the request or requests of the Holders. Registrations effected pursuant to this
Section 2.4 shall not be counted as demands for registration or registrations
effected pursuant to Sections 2.2 or 2.3, respectively. If the initiating
Holders intend to distribute Registrable Shares pursuant to an underwriting,
they shall so advise the Company in the demand pursuant to Section 2.2.1.

                  2.4.3    After the Company's Initial Public Offering, the
Company will use its best efforts to qualify for the registration of its shares
of Common Stock on Form S-3.

         2.5      EXPENSES OF REGISTRATION. Except as specifically provided
herein, all Registration Expenses incurred in connection with any registration,
qualification or compliance pursuant to Section 2.2 or any registration under
Section 2.3 or Section 2.4 herein shall be borne by the Company. All Selling
Expenses incurred in connection with any registrations hereunder, shall be borne
by the Company or the stockholders selling the securities. The Company shall
not, however, be required to pay for Registration

<PAGE>

Expenses regarding any registration proceeding begun pursuant to Section 2.2,
the request of which has been subsequently withdrawn by the Initiating Holders
(and such Initiating Holders hereby indemnify the Company against all such
expenses) unless (a) the withdrawal is based upon material adverse information
concerning the Company (including a material drop in the market price of the
Company's common stock) of which the Initiating Holders were not aware at the
time of such request or (b) the Holders of a majority of Registrable Securities
agree to forfeit their right to one requested registration pursuant to Section
2.2, in which event such right shall be forfeited by all Holders). If the
Holders are required to pay the Registration Expenses, such expenses shall be
borne by the holders of securities (including Registrable Securities) requesting
such registration in proportion to the number of shares for which registration
was requested.

         2.6      OBLIGATIONS OF THE COMPANY. Whenever required to register any
Registrable Securities, the Company shall, as expeditiously as reasonably
possible:

                  2.6.1    Prepare and file with the SEC a registration
statement with respect to such Registrable Securities and use all reasonable
efforts to cause such registration statement to become effective, and, upon the
request of the Holders of a majority of the Registrable Securities registered
thereunder, keep such registration statement effective for up to three months
for a registration pursuant to Section 2.2 and for up to six months for a
registration pursuant to Section 2.4 or, if earlier, until the Holder or Holders
have completed the distribution related thereto.

                  2.6.2    Prepare and file with the SEC such amendments and
supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement for the period set forth in
Section 2.6.1 above.

                  2.6.3    Furnish to the Holders such number of copies of a
prospectus, including a preliminary prospectus, in conformity with the
requirements of the Securities Act, and such other documents as they may
reasonably request in order to facilitate the disposition of Registrable
Securities owned by them.

                  2.6.4    Use its reasonable best efforts to register and
qualify the securities covered by such registration statement under such other
securities or Blue Sky laws of such jurisdictions as shall be reasonably
requested by the Holders; provided that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to
file a general consent to service of process in any such states or
jurisdictions.

                  2.6.5    In the event of any underwritten public offering,
enter into and perform its obligations under an underwriting agreement, in usual
and customary form, with the managing underwriter(s) of such offering.

                  2.6.6    Notify each Holder of Registrable Securities covered
by such registration statement at any time when a prospectus relating thereto is
required to be

<PAGE>

delivered under the Securities Act of the happening of any event as a result of
which the prospectus included in such registration statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading in the light of the circumstances then existing.

                  2.6.7    Use its best efforts to furnish, on the date that
such Registrable Securities are delivered to the underwriters for sale, if such
securities are being sold through underwriters, (a) an opinion, dated as of such
date, of the counsel representing the Company for the purposes of such
registration, in form and substance as is customarily given to underwriters in
an underwritten public offering, addressed to the underwriters, if any, and (b)
a letter dated as of such date, from the independent certified public
accountants of the Company, in form and substance as is customarily given by
independent certified public accountants to underwriters in an underwritten
public offering addressed to the underwriters.

         2.7      FURNISHING INFORMATION. It shall be a condition precedent to
the obligations of the Company to take any action pursuant to Section 2.2, 2.3
or 2.4 that the selling Holders shall furnish to the Company such information
regarding themselves, the Registrable Securities held by them and the intended
method of disposition of such securities as shall be required to effect the
registration of their Registrable Securities.

         2.8      INDEMNIFICATION. In the event any Registrable Securities are
included in a registration statement under Sections 2.2, 2.3 or 2.4:

                  2.8.1    To the extent permitted by law, the Company will
indemnify and hold harmless each Holder and the partners, officers, directors
and stockholders of each Holder, any underwriter (as defined in the Securities
Act) for such Holder and each person, if any, who controls such Holder or
underwriter within the meaning of the Securities Act or the Exchange Act,
against any losses, claims, damages, or liabilities (joint or several) to which
they may become subject under the Securities Act, the Exchange Act or other
federal or state law, insofar as such losses, claims, damages or liabilities (or
actions in respect thereof) arise out of or are based upon any of the following
statements, omissions or violations (collectively a "Violation") by the Company:
(a) any untrue statement or alleged untrue statement of a material fact
contained in such registration statement, including any preliminary prospectus
or final prospectus contained therein or any amendments or supplements thereto,
(b) the omission or alleged omission to state therein a material fact required
to be stated therein, or necessary to make the statements therein not
misleading, or (c) any violation or alleged violation by the Company of the
Securities Act, the Exchange Act, any state securities law or any rule or
regulation promulgated under the Securities Act, the Exchange Act or any state
securities law in connection with the offering covered by such registration
statement; and the Company will pay as incurred to each such Holder, partner,
officer, director, stockholder, underwriter or controlling person for any legal
or other expenses reasonably incurred by them in connection with investigating
or defending any such loss, claim, damage, liability or action; provided
however, that the indemnity agreement contained in this Section 2.8.1 shall not
apply to amounts paid in settlement of any such

<PAGE>

loss, claim, damage, liability or action if such settlement is effected without
the consent of the Company, which consent shall not be unreasonably withheld,
nor shall the Company be liable in any such case for any such loss, claim,
damage, liability or action to the extent that it arises out of or is based upon
a Violation which occurs in reliance upon and in conformity with written
information furnished expressly for use in connection with such registration by
such Holder, partner, officer, director, stockholder, underwriter or controlling
person of such Holder.

                  2.8.2    To the extent permitted by law, each Holder will, if
Registrable Securities held by such Holder are included in the securities as to
which such registration, qualification or compliance is being effected,
indemnify and hold harmless the Company, each of its directors, its officers and
each person, if any, who controls the Company within the meaning of the
Securities Act, any underwriter and any other Holder selling securities under
such registration statement or any of such other Holder's partners, directors,
officers or stockholders or any person who controls such Holder, against any
losses, claims, damages or liabilities to which the Company or any such person
may become subject under the Securities Act, the Exchange Act or other federal
or state law, insofar as such losses, claims, damages or liabilities (or actions
in respect thereto) arise out of or are based upon any Violation, in each case
to the extent (and only to the extent) that such Violation occurs in reliance
upon and in conformity with written information furnished by such Holder under
an instrument duly executed by such Holder and stated to be specifically for use
in connection with such registration; and each such Holder will pay as incurred
any legal or other expenses reasonably incurred by the Company or any such
person in connection with investigating or defending any such loss, claim,
damage, liability or action if it is judicially determined that there was such a
Violation; provided, however, that the indemnity agreement contained in this
Section 2.8.2 shall not apply to amounts paid in settlement of any such loss,
claim, damage, liability or action if such settlement is effected without the
consent of the Holder, which consent shall not be unreasonably withheld;
provided further, that in no event shall any indemnity under this Section 2.8
exceed the gross proceeds from the offering received by such Holder.

                  2.8.3    Promptly after receipt by an indemnified party under
this Section 2.8 of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 2.8, deliver to
the indemnifying party a written notice of the commencement thereof and the
indemnifying party shall have the right to participate in, and, to the extent
the indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; provided, however, that an indemnified party shall
have the right to retain its own counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the
counsel retained by the indemnifying party would be inappropriate due to actual
or potential differing interests between such indemnified party and any other
party represented by such counsel in such proceeding. The failure to deliver
written notice to the indemnifying party within a reasonable time of the
commencement of any such action, if materially prejudicial to its ability to
defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 2.8, but the omission so to deliver
written notice to

<PAGE>

the indemnifying party will not relieve it of any liability that it may have to
any indemnified party otherwise than under this Section 2.8.

                  2.8.4    If the indemnification provided for in this Section
2.8 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any losses, claims, damages or liabilities
referred to herein, the indemnifying party, in lieu of indemnifying such
indemnified party thereunder, shall to the extent permitted by applicable law
contribute to the amount paid or payable by such indemnified party as a result
of such loss, claim, damage or liability in such proportion as is appropriate to
reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the Violation(s) that resulted
in such loss, claim, damage or liability, as well as any other relevant
equitable considerations. The relative fault of the indemnifying party and of
the indemnified party shall be determined by a court of law by reference to,
among other things, whether the untrue or alleged untrue statement of a material
fact or the omission to state a material fact relates to information supplied by
the indemnifying party or by the indemnified party and the parties' relative
intent, knowledge, access to information and opportunity to correct or prevent
such statement or omission; provided, that in no event shall any contribution by
a Holder hereunder exceed the gross proceeds from the offering received by such
Holder.

                  2.8.5    The obligations of the Company and Holders under this
Section 2.8 shall survive completion of any offering of Registrable Securities
in a registration statement and the termination of this Agreement. No
Indemnifying Party, in the defense of any such claim or litigation, shall,
except with the consent of each Indemnified Party, consent to entry of any
judgment or enter into any settlement which does not include as an unconditional
term thereof the giving by the claimant or plaintiff to such Indemnified Party
of a release from all liability in respect to such claim or litigation.

         2.9      AMENDMENT OF REGISTRATION RIGHTS. Any provision of this
Section 2 may be amended and the observance thereof may be waived (either
generally or in a particular instance and either retroactively or
prospectively), only with the written consent of the Company and the Holders of
a majority of the Registrable Securities Then Outstanding. Any amendment or
waiver effected in accordance with this Section 2.9 shall be binding upon each
Holder and the Company. By acceptance of any benefits under this Section 2,
Holders of Registrable Securities hereby agree to be bound by the provisions
hereunder.

         2.10     LIMITATION ON SUBSEQUENT REGISTRATION RIGHTS. After the date
of this Agreement, the Company shall not, without the prior written consent of
the Holders of a majority of the Registrable Securities Then Outstanding, enter
into any agreement with any holder or prospective holder of any securities of
the Company that would grant such holder registration rights senior to those
granted to the Holders hereunder or that would limit in any way the registration
rights granted to the Holders hereunder.

<PAGE>

         2.11     "MARKET STAND-OFF" AGREEMENT; AGREEMENT TO FURNISH
INFORMATION.

                  2.11.1   Each Holder hereby agrees that such Holder shall not
sell or otherwise transfer or dispose of any Common Stock (or other securities)
of the Company held by such Holder (other than those included in the
registration) for a period specified by the representative of the underwriters
of Common Stock (or other securities) of the Company not to exceed 180 days
following the effective date of a registration statement of the Company filed
under the Securities Act; provided that:

                           2.11.1.1 such agreement shall apply only to the
Company's Initial Public Offering; and

                           2.11.1.2 all officers and directors of the Company
and holders of at least one percent of the Company's voting securities enter
into similar agreements.

                  2.11.2   Each Holder agrees to execute and deliver such other
agreements as may be reasonably requested by the Company or the underwriter
which are consistent with the foregoing or which are necessary to give further
effect thereto. In addition, if requested by the Company or the representative
of the underwriters of Common Stock (or other securities) of the Company, each
Holder shall provide, within ten days of such request, such information as may
be required by the Company or such representative in connection with the
completion of any public offering of the Company's securities pursuant to a
registration statement filed under the Securities Act. The obligations described
in this Section 2.12 shall not apply to a registration relating solely to
employee benefit plans on Form S-1 or Form S-8 or similar forms that may be
promulgated in the future, or a registration relating solely to a Commission
Rule 145 transaction on Form S-4 or similar forms that may be promulgated in the
future. The Company may impose stop-transfer instructions with respect to the
shares of Common Stock (or other securities) subject to the foregoing
restriction until the end of said 180 day period.

3.       COVENANTS OF THE COMPANY

         3.1      BASIC FINANCIAL INFORMATION AND REPORTING.

                  3.1.1    Within 120 days after the end of each fiscal year of
the Company, the Company will furnish each Investor a balance sheet of the
Company, as at the end of such fiscal year, and a statement of income and a
statement of cash flows of the Company, for such year, all prepared in
accordance with generally accepted accounting principles consistently applied
and setting forth in each case in comparative form the figures for the previous
fiscal year and the figures from the most recent budget approved by the Board of
Directors, all in reasonable detail. Such financial statements shall be
accompanied by a report and opinion thereon by independent public accountants of
national standing selected by the Board of Directors.

                  3.1.2    So long as an Investor (with its affiliates) owns at
least 320,000 shares of Registrable Securities (as adjusted for stock splits and
combinations) (a "Major Investor"), the Company will furnish each such Major
Investor (a) after approval by the Board of Directors an annual budget and
operating plan for each fiscal year (and as soon

<PAGE>

as available, any subsequent revisions thereto); and (b) within 30 days after
the end of each month, a balance sheet of the Company as of the end of each such
month.

         3.2      INSPECTION AND OBSERVATION RIGHTS.

                  3.2.1    INSPECTION RIGHTS. Each Major Investor shall have the
right to visit and inspect any of the properties of the Company or any of its
subsidiaries, and to discuss the affairs, finances and accounts of the Company
or any of its subsidiaries with its officers, and to review such information as
is reasonably requested all at such reasonable times and as often as may be
reasonably requested; provided, however, that the Company shall not be obligated
under this Section 3.2.1 to provide access and/or any information that it
reasonably considers to be a trade secret or similar confidential information or
to provide any information to any Investor that the Company reasonably believes
to be a competitor.

                  3.2.2    OBSERVATION RIGHTS. Each Major Investor, except Major
Investors representing institutional investment funds if there is an
Institutional Director as described in the Voting Agreement of even date
herewith, shall have the right to observe each meeting of the Board of Directors
provided that such Major Investor agrees to abide by role in board meetings as
established by the Board of Directors; provided, however, that the Company shall
not be obligated under this Section 3.2.2 to provide access and/or any
information that it reasonably considers to be a trade secret or similar
confidential information or to provide any information to any Investor that the
Company reasonably believes to be a competitor.

         3.3      CONFIDENTIALITY OF RECORDS. Except with respect to such
Investors as are parties to separate confidentiality agreements with the Company
(the terms of which separate confidentiality agreements shall control), each
Investor, on behalf of itself and its managers, directors, officers, employees
and agents (collectively, the "Investor Parties") agrees to hold any information
concerning the business and affairs of the Company (the "Confidential Material")
in strict confidence and to use such Confidential Information solely for the
purpose of evaluating and managing the Investor's investment in the Company and
only to make available such Confidential Information to such officers, employees
and representatives (including legal and accounting representatives) as is
reasonably necessary for the Investor to evaluate and manage the investment or
as may be required by law or regulation or to comply with the requirements of
(or to receive approvals from) any applicable governmental agency.
Notwithstanding the foregoing, "Confidential Information" shall not include any
information which: (a) is or becomes available to the public other than as a
result of a disclosure by such Investor; (b) was known to the Investor on a
nonconfidential basis prior to its disclosure to the Investor by the Company as
evidenced in writing; or (c) becomes available to the Investor on a
nonconfidential basis from a source other than the Company or its agents,
provided that such source is not bound by a confidentiality agreement with the
Company. The Investor may disclose Confidential Information to any partner,
subsidiary or parent of the Investor for the sole purpose of evaluating and
managing the Investor's investment in the Company as long as such partner,
subsidiary or parent agrees in writing to be bound by

<PAGE>

the confidentiality provisions of this Section 3.3 and such person is not a
competitor of the Company.

         3.4      RESERVATION OF COMMON STOCK. The Company will at all times
reserve and keep available, solely for issuance and delivery upon the conversion
of the Preferred Stock, all Common Stock issuable from time to time upon such
conversion.

         3.5      BOARD OF DIRECTORS. Unless otherwise agreed to by Investors
holding a majority of the Series A Preferred Stock, the Company shall maintain
the number of directors on the Board of Directors at between five and seven.

         3.6      TERMINATION OF COVENANTS. All covenants of the Company
contained in Section 3 of this Agreement (with the exception of section 3.4)
shall expire and terminate as to each Investor upon the earlier of (a) the
effective date of the registration statement pertaining to the Initial Public
Offering or (b) upon an acquisition of the Company by another corporation or
entity by consolidation, merger or other reorganization in which the holders of
the Company's outstanding voting stock immediately prior to such transaction,
together with their affiliates, own immediately after such transaction
securities representing less than 50% of the voting power of the corporation or
other entity surviving such transaction (a "Change in Control").

4.       RIGHT OF FIRST REFUSAL

         4.1      SUBSEQUENT OFFERINGS. In connection with subsequent equity
financings, the Investors shall have a right of first refusal to purchase their
pro rata share of all Equity Securities, as defined below, that the Company may,
from time to time, propose to sell and issue after the date of this Agreement,
other than the Equity Securities excluded by Section 4.5 hereof. The term
"Equity Securities" shall mean (a) any Common Stock or Preferred Stock of the
Company, (b) any security convertible, with or without consideration, into any
Common Stock or Preferred Stock (including any option to purchase such a
convertible security), (c) any security carrying any warrant or right to
subscribe to or purchase any Common Stock or Preferred Stock or (d) any such
warrant or right.

         4.2      EXERCISE OF RIGHTS. If the Company proposes to issue any
Equity Securities, it shall give the Investors notice of its intention,
describing the Equity Securities, the price and the terms and conditions upon
which the Company proposes to issue the same. The Investors shall have 15 days
from the giving of such notice to agree to purchase the Equity Securities for
the price and upon the terms and conditions specified in the notice by giving
notice to the Company and stating therein the quantity of Equity Securities they
agree to purchase.

         4.3      ISSUANCE OF EQUITY SECURITIES TO OTHER PERSONS. If the
Investors fail to exercise in full the rights of first refusal, the Company
shall have 120 days thereafter to sell such Equity Securities to any other
person(s), at a price and upon general terms and conditions materially no more
favorable to the purchasers thereof than were offered to the Investors pursuant
to Section 4.2 hereof.

<PAGE>

         4.4      TERMINATION AND WAIVER OF RIGHT OF FIRST REFUSAL. The right of
first refusal established by this Section 4 shall not apply to, and shall
terminate upon the effective date of the registration statement pertaining to
the Company's Initial Public Offering. The right of first refusal will also
terminate if (a) the Investors do not agree within the time provided in Section
4.2 to purchase all Equity Securities offered to them pursuant to Section 4.1
and (b) the Company sells the unpurchased Equity Securities to another person in
accordance with Section 4.3, unless the Company and the Investors agree that
such transaction will not cause a termination of the Investors' right of first
refusal. The provisions of this Section 4 may be amended or waived only by the
agreement of the Company and of Investors holding a majority of the number of
shares of voting capital stock of the Company held by the Investors at any time.

         4.5      EXCLUDED SECURITIES. The rights of first refusal established
by this Section 4 shall have no application to any of the following Equity
Securities:

                  4.5.1    shares of Common Stock (and/or options, warrants or
other Common Stock purchase rights issued pursuant to such options, warrants or
other rights) issued or to be issued to employees, officers or directors of, or
consultants or advisors to the Company or any subsidiary, pursuant to
compensation plans, agreements, or other arrangements that are approved by the
Board of Directors;

                  4.5.2    stock, options or warrants issued pursuant to any
rights or agreements outstanding as of the date of this Agreement,

                  4.5.3    options and warrants outstanding as of the date of
this Agreement;

                  4.5.4    stock issued pursuant to such rights or agreements
granted after the date of this Agreement, provided that the rights of first
refusal established by this Section 4 applied with respect to the initial sale
or grant by the Company of such rights or agreements;

                  4.5.5    any Equity Securities issued for consideration other
than cash pursuant to a merger, consolidation, acquisition or similar business
combination;

                  4.5.6    shares of Common Stock issued in connection with any
stock split, stock dividend or recapitalization by the Company;

                  4.5.7    shares of Common Stock issued upon conversion of the
Shares;

                  4.5.8    any Equity Securities issued pursuant to any
equipment leasing arrangement or debt financing from a bank or similar financial
institution or issued in connection with a bridge financing;

                  4.5.9    any Equity Securities issued in connection with
strategic transactions involving the Company and other entities, including (i)
joint ventures, manufacturing, marketing or distribution arrangements or (ii)
technology transfer or development arrangements; provided that such strategic
transactions and the issuance of shares therein has been approved by the Board
of Directors; and

<PAGE>

                  4.5.10   the Shares.

5.       MISCELLANEOUS

         5.1      GOVERNING LAW. This Agreement shall be governed by and
construed under the laws of the State of Delaware as applied to agreements among
Delaware residents entered into and to be performed entirely within Delaware.

         5.2      SURVIVAL. The representations, warranties, covenants, and
agreements made herein shall survive any investigation made by any Investor and
the closing of the transactions contemplated hereby. All statements as to
factual matters contained in any certificate or other instrument delivered by or
on behalf of the Company pursuant hereto in connection with the transactions
contemplated hereby shall be deemed to be representations and warranties by the
Company hereunder solely as of the date of such certificate or instrument.

         5.3      ENTIRE AGREEMENT. This Agreement, the Exhibits and Schedules
hereto, the Subscription Agreements, the Voting Agreement of even date herewith
among the Company and its stockholders, and the other documents delivered
pursuant thereto constitute the full and entire understanding and agreement
between the parties with regard to the subjects hereof and no party shall be
liable or bound to any other in any manner by any representations, warranties,
covenants and agreements except as specifically set forth herein and therein.

         5.4      SEVERABILITY. In case any provision of the Agreement shall be
invalid, illegal, or unenforceable, the validity, legality, and enforceability
of the remaining provisions shall not in any way be affected or impaired
thereby.

         5.5      AMENDMENT AND WAIVER.

                  5.5.1    Except as otherwise expressly provided, this
Agreement may be amended or modified only upon the consent of the Company and
the holders of at least a majority of the Registrable Securities; provided,
however, that the addition to an exhibit hereto of an individual or entity who
owns or acquires Shares shall require the consent of only the Company and such
individual or entity.

                  5.5.2    Except as otherwise expressly provided, the
obligations of the Company and the rights of the Holders under this Agreement
may be waived only with the consent of the holders of at least a majority of the
Registrable Securities.

                  5.5.3    All rights granted in this Agreement to Major Holders
may be amended or waived only upon the consent of the Company and the holders of
at least a majority of the Registrable Securities held by Major Holders.

         5.6      DELAYS OR OMISSIONS. It is agreed that no delay or omission to
exercise any right, power or remedy accruing to any Holder, upon any breach,
default or noncompliance of the Company under this Agreement shall impair any
such right, power

<PAGE>

or remedy, nor shall it be construed to be a waiver of any such breach, default
or noncompliance, or any acquiescence therein, or of any similar breach, default
or noncompliance thereafter occurring. It is further agreed that any waiver,
permit, consent or approval of any kind or character on any Holder's part of any
breach, default or noncompliance under the Agreement or any waiver on such
Holder's part of any provisions or conditions of this Agreement must be in
writing and shall be effective only to the extent specifically set forth in such
writing. All remedies, either under this Agreement, by law, or otherwise
afforded to Holders, shall be cumulative and not alternative.

         5.7      NOTICES AND CONSENTS. All notices and consents required or
permitted hereunder must be in writing and shall be deemed effectively given:
(a) upon personal delivery to the party to be notified, (b) when sent by
confirmed telex or facsimile if sent during normal business hours of the
recipient; if not, then on the next business day, (c) three business days after
having been sent by registered or certified mail, return receipt requested,
postage prepaid or (d) one business day after deposit with a nationally
recognized overnight courier, specifying next day delivery, with written
verification of receipt. All communications shall be sent to the party to be
notified at the address as set forth on the signature pages hereof or Exhibit A
hereto or at such other address as such party may designate by ten days advance
written notice to the other parties hereto.

         5.8      DISPUTE RESOLUTION. If any dispute arises under this
Agreement, the parties shall seek to resolve any such dispute between them in
the following manner:

                  5.8.1    Good Faith Negotiations. First, by promptly engaging
in good faith negotiations among senior executives of each party.

                  5.8.2    Mediation. If the parties are unable to resolve the
dispute within 20 business days following the first request by either party for
good faith negotiations, then the parties shall endeavor to resolve the dispute
by mediation administered by the American Arbitration Association ("AAA") under
its Commercial Mediation Rules.

                  5.8.3    Arbitration. If the parties are unable to resolve the
dispute within 30 days after the appointment of a mediator, the dispute shall be
resolved as follows:

                           5.8.3.1  The dispute shall be resolved by arbitration
conducted on a confidential basis under the then-current Commercial Arbitration
Rules and supervision of the AAA. If any part of this Section 5.9.3 is held to
be unenforceable, it will be severed and will not affect either the duty to
arbitrate or any other part of this Section 5.9.3. The arbitration will be held
in Philadelphia, PA before a sole disinterested arbitrator who is knowledgeable
in biotechnology and experienced in handling commercial disputes. The arbitrator
shall be appointed jointly by the parties hereto within 30 days following the
date on which the arbitration is instituted. If the parties are unable to agree
upon the arbitrator within such 30-day period, the AAA shall be instructed to
select such arbitrator within 15 days thereafter. The arbitrator's award will be
final and binding and may be entered in any court having jurisdiction. The
arbitrator will not have the power to award punitive or exemplary damages, or
any damages

<PAGE>

excluded by, or in excess of, any damage limitations expressed in this
Agreement. Issues of arbitrability will be determined in accordance solely with
the federal substantive and procedural laws relating to arbitration; in all
other respects, the arbitrator will be obligated to apply and follow the
substantive law of the State of Delaware.

                           5.8.3.2  Unless the arbitrator, if any, determines
otherwise, each party will bear its own attorneys' fees and other costs
associated with the negotiation and arbitration provided for hereunder, except
that costs and expenses of the arbitrators shall be shared equally. If court
proceedings to stay litigation or compel arbitration are necessary, the party
who unsuccessfully opposes such proceedings will pay all associated costs,
expenses and attorneys' fees which are reasonably incurred by the other party.

         5.9      EQUITABLE RELIEF. Neither party shall be precluded hereby from
securing equitable remedies in courts of any jurisdiction, including, but not
limited to, temporary restraining orders and preliminary injunctions to protect
its rights and interests, but such relief shall not be sought as a means to
avoid, delay or stay mediation, arbitration or Summary Proceeding.

         5.10     CONTINUING PERFORMANCE. Each party is required to continue to
perform its obligations under this contract pending final resolution of any
dispute arising out of or relating to this contract, unless to do so would be
impossible or impracticable under the circumstances.

         5.11     TITLES AND SUBTITLES. The titles of the sections and
subsections of this Agreement are for convenience of reference only and are not
to be considered in construing this Agreement.

         5.12     COUNTERPARTS. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date set forth in the first paragraph hereof

                                       ANIMAS CORPORATION

                                       By: __________________________
                                           Name: Katherine D. Crothall, Ph.D.
                                           Title: President

                  [SIGNATURE PAGE TO INVESTOR RIGHTS AGREEMENT]

<PAGE>

[IF SIGNING AS AN INDIVIDUAL]

___________________                    _________________________________________
       Dated                           Name: ___________________________________

                                       _________________________________________
                                       Number of shares of Common Stock voted

[IF SIGNING ON BEHALF OF AN ENTITY]

                                       _________________________________________
                                       Name of Entity Voting Common Stock

__________________                     By:______________________________________
      Dated                            Name: ___________________________________
                                       Title: __________________________________

                                       _________________________________________
                                       Number of Shares of Common Stock Voted

                  [SIGNATURE PAGE TO INVESTOR RIGHTS AGREEMENT]

<PAGE>

                                    EXHIBIT A

                              SCHEDULE OF INVESTORS
                                 (AS OF 1/13/00)

Allan Bedwick
Angus Burton
Anvers I, LLP
Anvers II, LLP
Joe Byrum
Katherine D. Crothall
Graeme A. Crothall
Peter and Jessica Crothall
Dexter Company Pension Plan
Fred Deutsch
James George, MD
William A. Graham IV
William Graham V
Laura M. Graham
Andrew Jay
Ralph Kemp
Norman W. Lefkovitz
Burr B. McKeehan Pension Plan
John Moran
Richard E. Moses and Bonnie Smith Moses, Tenants by the Entireties
A. Peter  Parsons 401(K) Pension Plan

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