Document:

Exhibit

***Text Omitted and Filed Separately
With Securities and Exchange Commission
Confidential Treatment Requested
Under 17 C.F.R. Sections 200.80(b)(4) and 240.24b-2 of the 
Securities Exchange Act of 1934, as amended.

	
													
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT
	1. CONTRACT ID CODE
	PAGE OF PAGES

	1
	4

	2. AMENDMENT/MODIFICATION NO

0049
	3. EFFECTIVE DATE

See Block 16C
	4. REQUISITION/PURCHASE REQ NO

N/A.
	5. PROJECT NO (if applicable)

	6. ISSUED BY   CODE
	ASPR-BARDA
	7. ADMINISTERED BY (if other than line item 6)   CODE
	ASPR-BARDA02

	ASPR-BARDA
200 Independence Ave., S.W.
Room 640-G
Washington DC 20201

	 
	ASPR-BARDA
330 Independence Ave., SW, Rm G640
Washington DC 20201
	 

	8. NAME AND ADDRESS OF CONTRACTOR (No, street, county, State and ZIP Code)
	(x)
	9A AMENDMENT OF SOLICITATION NO.

	CHIMERIX, INC.  1377270
CHIMERIX, INC.   2505 MERIDIAN P
2505 MERIDIAN PKWY STE 340
DURHAM NC 277135246
	 
	 

	9B DATED (SEE ITEM 11)

	x
	10A MODIFICATION OF CONTRACT/ORDER NO
HHSO100201100013C

	10B DATED (SEE ITEM 13)
 02/16/2011

	CODE     1377270
	FACILITY CODE

	11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

	 ̈   The above numbered solicitation is amended as set forth in Item 14.  The hour and date specified of receipt of Offers    ̈ is extended.      ̈ is not extended 
Offers must acknowledge receipt of this amendment prior to the hour end dale specified in the solicitation or as amended, by one or the following methods: (a) By completing Items 8 and 15, and returning __________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

	12. ACCOUNTING AND APPROPRIATION DATA (if required)
N/A.
	Net Increase:
	$2,812,858.00

	13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	CHECK ONE
	A.   THIS CHANGE ORDER IS ISSUED PURSUANT TO (Specify authority)  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO IN ITEM 10A

	 

	 
	B.   THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

	 
	C.   THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF

	X
	D.   OTHER (Specify type of modification and authority)
Bilateral:  Mutual Agreement of the Parties.

	E. IMPORTANT:            Contractor               ̈ is not.            ý is required to sign this document and return             0       copies to the issuing office.

	14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
Tax ID Number: 33-0903395
DUNS Number: 121785997
A.   The purpose of this modification is to incorporate the following changes into the contract:
1.   Under Contract Number HHSO100201100013C in SECTION G – CONTRACT ADMINISTRATION DATA, under Article G.10.  Government Property, the following is hereby added as Paragraph 7. and titled “disposition Instructions” as follows:
7.   Disposition Instructions
Continued ...
Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

	15A. NAME AND TITLE OF SIGNER (Type or print)
 Timothy W. Trost, SVP & CFO
	16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
ETHAN J. MUELLER

	15B. CONTRACTOR/OFFEROR
 /s/ Timothy W. Trost   
(Signature of person authorized to sign)
	15C. DATE SIGNED
2/26/18
	16B. UNITED STATES OF AMERICA
  /s/ Ethan J. Mueller     
(Signature of person authorized to sign)
	16C. DATE SIGNED
2/27/18

NSN 7540-01-152-8070    STANDARD FORM 30 (REV 10-83)
Previous edition unusable    Prescribed by GSA
FAR (48 CFR) 53.243

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0049
	PAGE      OF

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	NAME OF OFFEROR OR CONTRACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	Title for [...***...] under Contract Number HHSO100201100013C
that are no longer needed by the Government and have no commercial market value will hereby vest with the Contractor.
2.   In signing this no cost bilateral modification, the Contractor hereby certifies for both Chimerix and any of its subcontractors at any tier that the [...***...] under Contract Number HHS0100201100013C that are no longer needed by the Government and have no commercial market value that the Government will be turning title over to the Contractor will not be repurposed for use under any efforts in any methods that are prohibited by any federal, state and local laws and regulations and will not result in any costs being incurred under both Contract Number HHS0100201100013C and under any other U.S. Government contracts in effect as of the effective date of this modification and in signing this no cost bilateral modification, the Contractor also hereby certifies for both Chimerix and any of its subcontractors at any tier that the [...***...] under Contract Number HHS0100201100013C that are no longer needed by the Government and have no commercial market value that the Government will be turning title over to the Contractor will not be repurposed for the performance of any other efforts that are under the scope of Contract Number HHS0100201100013C nor under any other U.S. Government contracts in effect as of the effective date of this modification by either Chimerix or any of its subcontractors at any tier any will not result in any costs being incurred under both Contract Number HHSO100201100013C and under any other U.S. Government contracts.
3.   As consideration for the transfer of Title for [...***...] from the Government under Contract Number HHSO100201100013C to Chimerix, the Government and Chimerix hereby bilaterally and mutually agree to the following:
a.   For Option 1 CLIN 0002, for Modification 14, Total Estimated Cost – [...***...], Total Fixed Fee – [...***...] and Total Estimated cost Plus Fixed Fee – [...***...] Only, the following Indirect Cost Ceiling is established for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling:
[...***...]
b.   For Option 1 CLIN 0002 Cost Growth, for Modification 16, Total Estimated Cost – [...***...] Only, the following Indirect Cost Ceiling is established for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling:
[...***...]
c.   For Option 2 CLIN 0003, for Modification 19, Total Estimated Cost – [...***...], Total Fixed Fee – [...***...] and Total Estimated Cost Plus Fixed Fee – [...***...] Only, the following Indirect Cost Ceiling is established for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling and within the Total Estimated Cost of [...***...] Only:
[...***...]
d.   For Option 2 CLIN 0003 Cost Growth, for Modification 34, Total Estimated Cost – Continued ...

NSN 7540-152-8067    STANDARD FORM 336 (4-86)
Sponsored by GSA
FAR (48 CFR) 53.110

***Confidential Treatment Requested

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0049
	PAGE      OF

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	NAME OF OFFEROR OR CONTRACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	[...***...] Only, the following Indirect Cost Ceiling is established for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling and within the Total Estimated Cost of [...***...] Only:
[...***...]
e.   For Option 2 CLIN 0003, supplement for Modification 47, Total Estimated Cost – [...***...], Total Fixed Fee – [...***...] and Total Estimated Cost Plus Fixed Fee – [...***...] Only, the following Indirect Cost Ceiling Rates are established for which Chimerix cannot seek reimbursement in excess of the following indirect Cost Ceiling Rates:
[...***...]% Fringe,  [...***...]% G&A
f.   For CLIN 0004, for Modification 47, Total Estimated Cost – [...***...], Total Fixed Fee – [...***...] and Total Estimated Cost Plus Fixed Fee – [...***...] Only, the following Indirect Cost Ceiling is established for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling and within the Total Estimated Cost of [...***...] Only:
[...***...]
g.   For any Indirect Rates for Calendar Years 2018 and beyond under this contract, the following Indirect Rates are established as Indirect Cost Ceiling Rates for which Chimerix cannot seek reimbursement in excess of the following Indirect Cost Ceiling Rates;
[...***...]% Fringe,  [...***...]% G&A
h.   In signing this no cost bilateral modification, Chimerix hereby certifies that they have received as of the executed date of this modification full payment under both CLIN 0001 and CLIN 0002 (Including any supplemental amounts) for all indirect expenses (both forward billing indirect expenses and retroactive billing indirect expenses) and will seek no further payment/reimbursement from the Government for indirect expenses under both CLIN 0001 and CLIN 0002 (Including any supplemental amounts).
4.   The total amount, scope and period of performance of all other CLINs that are currently being performed under the contract remain unchanged.  This modification does not exercise any unexercised Option CLINs under the contract and does not authorize any performance of efforts under any unexercised Option CLINs under the contract.  In addition, the total amount, scope an period of performance of all unexercised Option CLINs under the contract remain unchanged.  This modification also confirms that all activities under the base period of performance CLIN 0001 were completed as of 31 May 2013 and confirms that all activities under the Option 1/CLIN 0002 period of performance were completed as of 30 April 2015.
B.   This is a no cost bilateral modification.  All other terms and conditions of Contract Number HHS0100201100013C remain unchanged.
Continued . . .

NSN 7540-152-8067    STANDARD FORM 336 (4-86)
Sponsored by GSA
FAR (48 CFR) 53.110

***Confidential Treatment Requested

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0049
	PAGE      OF

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	NAME OF OFFEROR OR CONTRACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	

Period of Performance: 02/16/2011 to 09/30/2018

NSN 7540-152-8067    STANDARD FORM 336 (4-86)
Sponsored by GSA
FAR (48 CFR) 53.110Exhibit

FIRST AMENDMENT TO INDUSTRIAL BUILDING LEASE 

This First Amendment to Industrial Building Lease (this “Amendment”) is dated to be effective as of December 14, 2017 (the “Effective Date”), by and between CLPF-RESEARCH CENTER, LLC, a Delaware limited liability company, successor-in-interest to NORTHWOOD RTC LLC, a Delaware limited liability company (“Landlord”), and CHIMERIX, INC., a Delaware corporation (“Tenant”).

R E C I T A L S

WHEREAS, Landlord and Tenant entered into that certain Industrial Building Lease dated March 10, 2014 (the “Original Lease”, with the Original Lease and this Amendment being collectively hereinafter referred to as the “Lease”), for the leasing of approximately 7,925 square feet of space known as Suite E (the “Premises”) in the building commonly known as Research Tri-Center North I, located at 3501 Tri-Center Boulevard, Durham, North Carolina 27713 (the “Building”), which Building is part of that certain industrial project commonly known as Research Tri-Center (the “Project”), as more particularly described in the Lease. 

WHEREAS, Tenant and Landlord desire to modify the Original Lease pursuant to the terms herein.

NOW, THEREFORE, in consideration of the mutual covenants and agreements of the parties and other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, it is the sole intent of Landlord and Tenant to hereby amend the Lease as follows:

1.Extension of Lease Term and Base Rent. 

(a) Landlord and Tenant acknowledge and agree that, pursuant to the Original Lease, the Lease Term expires on July 31, 2018, however, Landlord and Tenant hereby agree to extend the Lease Term commencing on August 1, 2018 (the “Extension Commencement Date”) and expiring on July 31, 2021, and the Base Rent during such extension shall be as follows:  

	
				
	Months
	Annual Base Rent Rate Per Sq. Ft.

	Annual Base Rent
	Monthly Installment of Base Rent

	August 1, 2018 – July 31, 2019
	$17.50
	$138,687.50
	$11,557.29

	August 1, 2019 – July 31, 2020
	$18.03
	$142,887.75
	$11,907.32

	August 1, 2020 – July 31, 2021
	$18.57
	147.167.25
	$12,263.94

Except as expressly amended or modified in this Amendment, Tenant will continue to pay all rent, including monthly Base Rent, Additional Rent and all other charges and expenses pursuant to the applicable terms and conditions of the Lease.

Fourth Amendment to Industrial Building Lease                    
PAGE 1

(b)    Tenant and Landlord acknowledge and agree that except as expressly set forth in Section 2 below, Tenant shall have no right or option to extend the Lease Term beyond July 31, 2021.

		
	2.
	Renewal Option.

(a)    Provided that no Event of Default has occurred, and Tenant is occupying the entire Premises at the time of such election, Tenant may renew the Lease Term for one (1) additional period of five (5) years (the “Renewal Term”), by delivering written notice of the exercise thereof to Landlord not later than twelve (12) months before the expiration of the Lease Term (as such Lease Term is extended pursuant to Section 1 of this Amendment).  The monthly Base Rent payable for each month during the Renewal Term shall be the Fair Market Value (hereinafter defined), as determined by Landlord at the commencement of the Renewal Term, provided, however, in no event shall the Fair Market Value be less than the Base Rent rate at the expiration of the Lease Term.  As used herein, the term “Fair Market Value” shall: (1) mean the prevailing market rate at the commencement of the Renewal Term for leases in the RTP / I-40 corridor submarket of Raleigh/Durham, North Carolina of equivalent quality, size, utility and for similarly constructed buildings, (2) take into consideration the finish out and improvements within the Premises, and (3) take the length of the Renewal Term and the credit standing of Tenant into account.  Within 30 days after receipt of Tenant’s written notice to renew, Landlord shall deliver to Tenant written notice of the Fair Market Value and shall advise Tenant of the required adjustment to monthly Base Rent, if any, and the other terms and conditions offered, if any.  Tenant shall, within ten (10) business days after receipt of Landlord’s notice, notify Landlord in writing whether Tenant accepts or rejects Landlord’s determination of the Fair Market Value and the other terms offered, if any.  If Tenant timely notifies Landlord that Tenant accepts Landlord’s determination of the Fair Market Value and the other terms offered, if any, in the time set forth herein (time being of the essence), then, on or before the commencement date of the Renewal Term, Landlord and Tenant shall execute an amendment to this Lease extending the Lease Term on the same terms provided in this Lease, except as follows: (i) monthly Base Rent shall be adjusted to the Fair Market Value; (ii) Tenant shall have no further renewal option unless expressly granted by Landlord in writing pursuant to a subsequent written agreement between Landlord and Tenant; (iii) any other terms and conditions agreed upon by Landlord and Tenant shall be included in such amendment; and (iv) Landlord shall lease to Tenant the Premises in their then-current condition, and, unless otherwise expressly agreed to between Landlord and Tenant in a written amendment to the Lease, Landlord shall not provide to Tenant any allowances (e.g., moving allowance, construction allowance, and the like) or other tenant inducements. 

(b)    If Tenant rejects Landlord’s determination of the Fair Market Value, or fails to timely notify Landlord in writing that Tenant accepts or rejects Landlord’s determination of the Fair Market Value, or fails to execute an amendment to this Lease in connection with the exercise of its renewal option within twenty (20) days after receipt from Landlord, time being of the essence with respect thereto, Tenant’s rights under this Section 3 to extend the Lease Term for the Renewal Term shall terminate and Tenant shall have no right to renew this lease.

First Amendment to Industrial Building Lease                                PAGE 2

(c)    Tenant’s renewal rights under this Section 2 shall terminate if (1) this Lease or Tenant’s right to possession of the Premises is terminated, (2) Tenant assigns any of its interest in this Lease or sublets the Premises, (3) Tenant fails to timely exercise its option under this paragraph or fails to timely execute and return an acceptable form of the lease amendment reference above, time being of the essence with respect thereto, or (4) Landlord determines, in its sole but reasonable discretion, that at the expiration of the Lease Term, Tenant’s tangible net worth has materially deteriorated compared with its tangible net worth as of the Effective Date.

3.    AS IS Condition of Premises.  Tenant accepts the Premises (including, without limitation, all equipment, fixtures, systems and racking therein), the Building, the Common Areas and the Project in their AS IS, WHERE IS, WITH ALL FAULTS condition and state of repair existing as of the Effective Date, and Tenant agrees that Landlord shall not be required to perform any work, supply any materials, or incur any expense to prepare the Premises for Tenant’s occupancy, provided, however, nothing herein shall relieve Landlord of its obligations under Section 8 of the Lease..   Tenant shall, at its sole cost and expense, be solely responsible to obtain any and all licenses, permits and/or consents, if any, related to its use and occupancy of the Premises. 

4.    Release of Landlord. Tenant, for itself and on behalf of its owners, employees, officers, subsidiaries and divisions, hereby waives and releases any and all known claims and causes of action, if any, which it has or may have against Landlord or any of its agents arising out of or in any way related to, directly or indirectly, the Original Lease and this Amendment, and/or the operation or condition of the Project, the Building and/or the Premises.

5.    Brokers.  Landlord and Tenant represent and warrant that they have dealt with no broker, agent or other person in connection with this transaction except for Davis Moore Capital, who represents Tenant (the “Tenant’s Broker”), and Foundry Commercial, who represents Landlord (the “Landlord’s Broker”), and except for the Tenant’s Broker and Landlord’s Broker, no other broker, agent or other person brought about this transaction.  Landlord agrees to pay a commission to the Tenant’s Broker and the Landlord’s Broker pursuant to a separate written agreement(s) between Landlord, Tenant’s Broker, and Landlord’s Broker.  Landlord and Tenant hereby indemnify and hold each other harmless against any loss, claim, expense or liability with respect to any commissions or brokerage fees claimed by any broker or finder other than the Tenant’s Broker and Landlord’s Broker on account of the execution of this Amendment and the transactions contemplated herein due to any action of the indemnifying party.
 
5.    Miscellaneous.   Landlord and Tenant represent each to the other that it has full right and authority to enter into this Amendment.  All other terms and conditions of the Lease, except as specifically amended or modified by this Amendment, shall remain in effect and unchanged.  All terms used herein having initial capital letters and not otherwise herein defined shall have the meaning ascribed to such terms in the Lease, and effective as of the Effective Date, any defined terms in the Lease that are also defined herein, shall be replaced with the defined terms in this Amendment.  If any conflict exists between the provisions in this Amendment and the Original Lease, then this Amendment controls.  The Lease, including this Amendment, constitutes the entire agreement of the Landlord and Tenant with respect to the subject matter of the Lease and this Amendment, and contains all of the covenants and agreements of Landlord and Tenant with respect 

First Amendment to Industrial Building Lease                                PAGE 3

thereto.  The recitals set forth above are true and correct and are hereby incorporated herein by this reference.  Landlord and Tenant each acknowledge that no representations, inducements, promises or agreements, oral or written, have been made by Landlord or Tenant, or anyone acting on behalf of Landlord or Tenant, which are not contained herein, and any prior agreements, promises, negotiations, or representations not expressly set forth in this Amendment are of no effect.  This Amendment may not be altered, changed or amended except by an instrument in writing signed by both parties hereto.  Except as modified in this Amendment, Landlord and Tenant hereby ratify and confirm all provisions of the Lease.  Accordingly, the parties agree that the Lease remains in full force and effect with the exception of the lease terms and obligations that are amended herein.

[Signatures To Follow On Next Page]
[Remainder Of This Page Left Intentionally Blank]

First Amendment to Industrial Building Lease                                PAGE 4

THIS FIRST AMENDMENT TO INDUSTRIAL BUILDING LEASE is dated to be effective as of the date first written above.

		
	TENANT:
	CHIMERIX, INC., 

a Delaware corporation

By:    /s/ Timothy W. Trost            
Name:         Timothy W. Trost            
Title:         SVP and CFO                                

LANDLORD:         CLPF-RESEARCH CENTER, LLC,
     a Delaware limited liability company

By:    Clarion Lion Properties Fund Holdings, L.P.,
its sole member

By:    CLPF-Holdings, LLC, its general partner

By:    Clarion Lion Properties Fund Holdings REIT, LLC,
its sole member

By:    Clarion Lion Properties Fund, LP, 
its managing member

By:    Clarion Partners LPF GP, LLC, its general partner

           By:          Clarion Partners, LLC, its sole member

By:    /s/ Jesse Harty                
Name:         Jesse Harty                
Title:           Vice President            

First Amendment to Industrial Building Lease                                PAGE 5

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