Document:

Exhibit 10.8

    

    

    SANDBRIDGE ACQUISITION CORPORATION

    1999 Avenue of the Stars, Suite 2088

    Los Angeles, CA 90067

    

    

    July __, 2020

    

    

    Sandbridge Capital, LLC

    1999 Avenue of the Stars, Suite 2088

    Los Angeles, CA 90067

    

    

    Re:          Administrative Services Agreement

    

    

    Ladies and Gentlemen:

    

    

    This letter agreement by and between Sandbridge Acquisition Corporation (the “Company”) and Sandbridge Capital, LLC (the “Sandbridge”),
      dated as of the date hereof, will confirm our agreement that, commencing on the effective date (the “Effective Date”) of the Registration Statement on Form S-1 filed with the U.S. Securities and Exchange
      Commission (the “Registration Statement”) for the Company’s initial public offering and continuing until the earlier of the consummation by the Company of an initial business combination or the Company’s
      liquidation (in each case as described in the Registration Statement) (such earlier date hereinafter referred to as the “Termination Date”):

    

    

    	i.	
            Sandbridge shall make available, or cause to be made available, to the Company, at 1999 Avenue of the Stars, Suite 2088, Los Angeles, CA 90067 (or any successor location or other existing office locations), certain office space, utilities
              and secretarial and administrative support as may be reasonably required by the Company. In exchange therefor, the Company shall pay Sandbridge the sum of $10,000 per month commencing on the Effective Date and continuing monthly thereafter
              until the Termination Date; and

          

    

    

    	ii.	
            Sandbridge hereby irrevocably waives any and all right, title, interest, causes of action and claims of any kind as a result of, or arising out of, this letter agreement (each, a “Claim”) in or to,
              and any and all right to seek payment of any amounts due to it out of, the trust account established for the benefit of the public stockholders of the Company and into which substantially all of the proceeds of the Company’s initial public
              offering will be deposited (the “Trust Account”), and hereby irrevocably waives any Claim it may have in the future, which Claim would reduce, encumber or otherwise adversely affect the Trust Account or
              any monies or other assets in the Trust Account, and further agrees not to seek recourse, reimbursement, payment or satisfaction of any Claim against the Trust Account or any monies or other assets in the Trust Account for any reason
              whatsoever.

          

    

    

    This letter agreement constitutes the entire agreement and understanding of the parties hereto in respect of its subject matter and supersedes all prior understandings, agreements, or representations by or among the
      parties hereto, written or oral, to the extent they relate in any way to the subject matter hereof or the transactions contemplated hereby.

    

    

    This letter agreement may not be amended, modified or waived as to any particular provision, except by a written instrument executed by all parties hereto.

    

    

    No party hereto may assign either this letter agreement or any of its rights, interests, or obligations hereunder without the prior written approval of the other party. Any purported assignment in violation of this
      paragraph shall be void and ineffectual and shall not operate to transfer or assign any interest or title to the purported assignee.

    

    

    Any litigation between the parties (whether grounded in contract, tort, statute, law or equity) shall be governed by, construed in accordance with, and interpreted pursuant to the laws of the State of New York, without
      giving effect to its choice of laws principles.

    

    

    This letter agreement may be executed by any one or more of the parties hereto in any number of counterparts, each of which shall be deemed to be an original, but all such counterparts shall together constitute one and
      the same instrument. Counterparts may be delivered via facsimile, electronic mail (including any electronic signature covered by the U.S. federal ESIGN Act of 2000,
      Uniform Electronic Transactions Act, the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and
      be valid and effective for all purposes.

     

    

    
      	 	
              Very truly yours,

            
	 	 
	 	
              SANDBRIDGE ACQUISITION CORPORATION

            
	 	 
	 	 
	 	
              By:

            	 
	 	
              Name:

            	 
	 	
              Title:

            	 

       

      

      
        	
                AGREED TO AND ACCEPTED BY:

              	 
	 	 
	
                SANDBRIDGE CAPITAL, LLC

              	 
	 	 
	 	 
	
                By:

              	 	 
	
                Name:

              	 	 
	
                Title:EX-10.8

 Exhibit 10.8 

METACRINE, INC. 

EXECUTIVE EMPLOYMENT AGREEMENT 

This Executive Employment Agreement (the “Agreement”) is made and entered into effective as of
May 29, 2020 (the “Effective Date”), by and between Preston S. Klassen, MD, MHS (“Executive”) and Metacrine, Inc. (the “Company”). 

WHEREAS, the Company and Executive desire to enter into this Agreement to
define their mutual rights and duties with respect to Executive’s compensation and benefits. 

NOW, THEREFORE, in consideration of
the mutual promises and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 

1. Employment by the Company. 

1.1 Position. Executive shall serve as the Company’s Chief Executive Officer (“CEO”).
Executive’s start date will be June 8, 2020, or such other date as mutually agreed by Executive and the Company (the “Start Date”). During the term of Executive’s employment with the Company, Executive will
devote Executive’s best efforts and substantially all of Executive’s business time and attention to the business of the Company, except for approved vacation periods and reasonable periods of illness or other incapacities permitted by the
Company’s general employment policies. Executive acknowledges that he will be appointed to the Company’s Board of Directors (the “Board”) effective as of the Start Date. If Executive ceases to serve as CEO of the
Company for any reason, then Executive will resign from his position as a member of the Board, if and as requested by the Board. 

1.2 Duties and Location. Executive shall perform such duties as are customarily associated with the position of CEO and
such other duties as are assigned to Executive by the Board. Executive’s primary office location shall be the Company’s headquarters located in San Diego, California. Subject to the terms of this Agreement, the Company reserves the right
to (a) reasonably require Executive to perform Executive’s duties at places other than Executive’s primary office location from time to time and to require reasonable business travel, and (b) modify Executive’s job title and
duties as it deems necessary and appropriate in light of the Company’s needs and interests from time to time. 
 1.3
Policies and Procedures. The employment relationship between the parties shall be governed by the general employment policies and practices of the Company, except that when the terms of this Agreement differ from or are in conflict with the
Company’s general employment policies or practices, this Agreement shall control. 
 2. Cash Compensation. 

2.1 Base Salary. For services to be rendered hereunder, Executive shall receive a base salary at the rate of $450,000
per year (the “Base Salary”), less standard payroll deductions and withholdings and payable in accordance with the Company’s regular payroll schedule. The 

  
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Board (or the Compensation Committee thereof) may review Executive’s Base Salary for adjustment from time to time. 

2.2 Signing Bonus. The Company shall pay Executive a lump sum cash signing bonus of $100,000.00 (the
“Signing Bonus”), less payroll deductions and withholdings, within 30 days of the Start Date. If Executive’s employment with the Company ceases due to a termination with Cause or Executive’s resignation for
other than Good Reason (as such terms are defined below) at any time within the first 12 months following the Start Date, Executive shall be required to repay the Signing Bonus to the Company within 30 days of such termination. If
Executive’s employment with the Company ceases due to a termination with Cause or Executive’s resignation for other than Good Reason at any time after the first 12 months and before the first 24 months following the Start Date,
Executive shall be required to repay 50% of the Signing Bonus to the Company within 30 days of such termination. 

2.3 Annual Target Bonus. Executive will be eligible to be considered for a discretionary annual performance bonus of up
to 50% of the Base Salary, based on achievement of individual and/or corporate performance targets, metrics and/or objectives to be determined and approved by the Board or the Compensation Committee thereof, including pursuant to an annual incentive
plan or similar plan approved by the Board, if any. Any such bonus would be paid after the close of the fiscal year and after determination by the Board (or the Compensation Committee thereof) of (i) the level of achievement of the applicable
individual and corporate performance targets, metrics and/or objectives and (ii) the amount of the annual incentive compensation earned by Executive (if any). No annual incentive compensation is guaranteed and, in addition to the other
conditions for earning such compensation, Executive must remain an employee in good standing of the Company on the annual incentive compensation payment date in order to be eligible for any annual incentive compensation. The Board (or the
Compensation Committee thereof) may review Executive’s annual performance bonus amount for adjustment from time to time. 

3. Standard Company Benefits. Executive shall, in accordance with Company policy and the terms and conditions of the
applicable Company benefit plan documents, be eligible to participate in the benefit and fringe benefit programs provided by the Company to its executive officers and other employees from time to time. Any such benefits shall be subject to the terms
and conditions of the governing benefit plans and policies and may be changed by the Company in its discretion. 
 4.
Expenses. The Company will reimburse Executive for reasonable travel, entertainment or other expenses incurred by Executive in furtherance or in connection with the performance of Executive’s duties hereunder, in accordance with the
Company’s expense reimbursement policy as in effect from time to time. 
 5. Equity Awards. 

5.1 Initial Option. As further consideration for Executive’s employment, promptly following Executive’s Start
Date and subject to approval by the Board, Executive will be granted a nonstatutory stock option (the “Initial Option”) under the Company’s 2015 Equity Incentive Plan, as amended (the “Plan”) to
purchase that number of shares of the Company’s common stock that is equal to 4.25% of the fully-diluted capitalization of the Company (defined 

  
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below) on the date of grant. The Initial Option will have an exercise price equal to the fair market value of the Common Stock as of the date of grant as determined by the Board and shall vest as
follows: (i) 25% of the shares subject to the Initial Option shall vest twelve months after the Start Date, subject to Executive’s continuing employment with the Company, and no shares shall vest before such date and (ii) the remaining
shares shall vest monthly on the last day of the each of the following 36 months in equal monthly amounts subject to Executive’s continuing employment with the Company. The terms of the Initial Option are more fully set forth in the Plan and
related grant notice and stock option agreement (together, the “Equity Documents”). For the purposes of this Agreement “fully-diluted capitalization of the Company” means the number of shares of the
Company’s Common Stock actually outstanding plus the number of shares of Common Stock issuable upon the conversion of all shares of preferred stock actually outstanding plus the number of shares of stock subject to outstanding warrants and
outstanding equity awards (whether or not vested). 
 5.2 Performance-Based Option. As further consideration for
Executive’s employment, promptly following Executive’s Start Date and subject to approval by the Board, Executive will be granted a nonstatutory stock option (the “Performance Option”) under the Plan to purchase
that number of shares of the Company’s common stock that is equal to 0.25% of the fully-diluted capitalization of the Company on the date of grant. The Performance Option will have an exercise price equal to the fair market value of the Common
Stock as of the date of grant as determined by the Board and shall vest as follows: (i) none of the shares subject to the Performance Option shall vest prior to the closing of an initial public offering of the Company’s common stock
pursuant to a firmly underwritten offering registered on Form S-1 in which the gross proceeds to the Company (prior to underwriting discounts and expenses) are least $100 million (the date of such
closing, the “Vesting Trigger”) and (ii) the shares shall vest monthly on the last day of the each of the 24 months following the Vesting Trigger (with the first such vesting date being the last day of the month in which
the Vesting Trigger occurs) in equal monthly amounts subject to Executive’s continuing employment with the Company. The terms of the Performance Option are more fully set forth in the Equity Documents. 

6. Proprietary Information Obligations. 

6.1 Proprietary Information Agreement. As a condition to employment, Executive agrees to execute, and will continue to
abide by the Company’s standard Confidential Information and Invention Assignment Agreement attached hereto as EXHIBIT A (“Proprietary Agreement”). 

6.2 Third-Party Agreements and Information. Executive represents and warrants that Executive’s employment by the
Company does not conflict with any prior employment or consulting agreement or other agreement with any third party, and that Executive will perform Executive’s duties to the Company without violating any such agreement. Executive represents
and warrants that Executive does not possess confidential information arising out of prior employment, consulting, or other third party relationships, that would be used in connection with Executive’s employment by the Company, except as
expressly authorized by that third party. During Executive’s employment by the Company, Executive will use in the performance of Executive’s duties only information that is generally known and used by persons with training and experience
comparable to Executive’s own, common knowledge in the industry, otherwise legally 

  
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in the public domain, or obtained or developed by the Company or by Executive in the course of Executive’s work for the Company. 

7. Outside Activities and Non-Competition and
No-Solicit. 
 7.1 Outside Activities. Throughout Executive’s
employment with the Company, Executive may engage in civic and not-for-profit activities so long as such activities do not interfere with the performance of
Executive’s duties hereunder or present a conflict of interest with the Company or its affiliates. Subject to the restrictions set forth herein, and only with prior written disclosure to and consent of the Board, Executive may engage in other
types of business or public activities. The Board may rescind such consent, if the Board determines, in its sole discretion, that such activities compromise or threaten to compromise the Company’s or its affiliates’ business interests or
conflict with Executive’s duties to the Company or its affiliates. 
 7.2
Non-Competition During Employment. Except as otherwise provided in this Agreement, during Executive’s employment by the Company, Executive will not, without the express written consent of the Board,
directly or indirectly serve as an officer, director, stockholder, employee, partner, proprietor, investor, joint venturer, associate, representative or consultant of any person or entity engaged in, or planning or preparing to engage in, business
activity competitive with any line of business engaged in (or planned to be engaged in) by the Company or its affiliates; provided, however, that Executive may purchase or otherwise acquire up to (but not more than) one percent (1%) of any class of
securities of any enterprise (without participating in the activities of such enterprise) if such securities are listed on any national or regional securities exchange. In addition, Executive will be subject to certain restrictions (including
restrictions continuing after Executive’s employment ends) under the terms of the Proprietary Agreement. 
 7.3 Non-Solicitation. Executive agrees that during the period of employment with the Company and for twelve (12) months after the date Executive’s employment is terminated for any reason, Executive will
not, either directly or through others, solicit or encourage or attempt to solicit or encourage any employee, independent contractor, or consultant of the Company to terminate his or her relationship with the Company in order to become an employee,
consultant or independent contractor to or for any other person or entity. 
 8. Termination of Employment; Severance and
Change in Control Benefits. 
 8.1 At-Will Employment. Executive’s
employment relationship is at-will. Either Executive or the Company may terminate the employment relationship at any time, with or without Cause (as defined below) or advance notice. In the event
Executive’s employment with the Company is terminated for any reason, Executive will be entitled to all of Executive’s earned compensation and benefits or otherwise as required by law through the date of termination. For the avoidance of
doubt, Executive shall not be entitled to any additional compensation or benefits hereunder in the event Executive’s employment is terminated for Cause, due to Executive’s resignation without Good Reason, upon Executive’s death or
Executive’s Disability (as defined below); provided that this Section 8.1 does not purport to alter (a) any separate agreement entered into after the Effective Date and pursuant which Executive is expressly entitled to benefits
or other compensation on or after the events set forth in this sentence, including, if applicable, the Equity 

  
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Documents, or (b) any agreements between the Executive and any third party, including insurance policies or the like. If Executive’s employment terminates due to an Involuntary
Termination (as defined below), Executive will be eligible to receive the additional compensation and benefits described in Sections 8.2 and 8.3, as applicable. 

8.2 Termination Without Cause or Resignation for Good Reason Unrelated to Change in Control. If at any time
(i) the Company terminates Executive’s employment without Cause (as defined below and other than as a result of Executive’s death or Disability), or (ii) Executive resigns for Good Reason (as defined below), and provided in any
case such termination constitutes a “separation from service”, as defined under Treasury Regulation Section 1.409A-1(h)) (a “Separation from Service”) (such termination
described in (i) or (ii), an “Involuntary Termination”), Executive shall be entitled to receive the following severance benefits, subject in all events to Executive’s compliance with Section 8.4 below: 

(i) Executive shall receive severance pay in the form of continuation of Executive’s base salary in effect
(ignoring any decrease that forms the basis for Executive’s resignation for Good Reason, if applicable) on the effective date of Executive’s Involuntary Termination for the first nine (9) months (the “Severance
Period”) after the date of such termination; and 
 (ii) If Executive is eligible for and timely elects
to continue Executive’s health insurance coverage under the Company’s group health plans under the Consolidated Omnibus Budget Reconciliation Act of 1985 or the state equivalent (“COBRA”) following Executive’s
termination date, the Company will pay the COBRA group health insurance premiums for Executive and Executive’s eligible dependents until the earliest of (A) the close of the Severance Period, (B) the expiration of Executive’s
eligibility for the continuation coverage under COBRA, or (C) the date when Executive becomes eligible for substantially equivalent health insurance coverage in connection with new employment or self-employment. For purposes of this Section,
references to COBRA premiums shall not include any amounts payable by Executive under a Section 125 health care reimbursement plan under the U.S. Internal Revenue Code. Notwithstanding the foregoing, if at any time the Company determines, in
its sole discretion, that it cannot pay the COBRA premiums without potentially incurring financial costs or penalties under applicable law (including, without limitation, Section 2716 of the Public Health Service Act), then regardless of
whether Executive elects continued health coverage under COBRA, and in lieu of providing the COBRA premiums, the Company will instead pay Executive on the last day of each remaining month of the Severance Period, a fully taxable cash payment equal
to the COBRA premiums for that month, subject to applicable tax withholdings (such amount, the “Health Care Benefit Payment”). The Health Care Benefit Payment shall be paid in monthly installments on the same schedule that
the COBRA premiums would otherwise have been paid and shall be equal to the amount that the Company would have otherwise paid for COBRA premiums, and shall be paid until the earlier of (i) expiration of the Severance Period or (ii) the
date when Executive becomes eligible for substantially equivalent health insurance coverage in connection with new employment or self-employment. 

8.3 Termination Without Cause or Resignation for Good Reason During Change in Control Period. In the event of an
Involuntary Termination at any time during the time period commencing three (3) months immediately prior to the effective date of a Change in 

  
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Control (as defined in the Plan) and ending on the date that is twelve (12) months after the effective date of a Change in Control, in addition to the payments and benefits described in
Section 8.2, and subject in all events to Executive’s compliance with Section 8.4 below, then notwithstanding anything to the contrary set forth in the Plan or any successor equity incentive plan or any award agreement, the vesting of
all of Executive’s then-outstanding stock awards, including the Initial Option, that are subject to time-based vesting shall be fully accelerated such that on the effective date of such termination one hundred percent (100%) of the shares
subject to time-based vesting in such stock awards granted to Executive prior to the effective date of such termination shall be fully vested and immediately exercisable by Executive. Treatment of any performance-based vesting equity awards,
including the Performance Option prior to the Vesting Trigger, will be governed solely by the terms of the agreements under which such awards were granted and will not be eligible to accelerate vesting pursuant to the foregoing provision. 

8.4 Conditions and Timing for Severance Benefits. The severance benefits set forth in Sections 8.2 and 8.3 above are
expressly conditioned upon: (i) Executive’s continuing to comply with Executive’s obligations under Executive’s Proprietary Agreement; and (ii) Executive signing and not revoking a general release of legal claims in the form
provided by the Company which shall include a full general release of claims against the Company and related persons and entities, a commitment from Executive to comply with Executive’s continuing obligations under Executive’s Proprietary
Agreement and a nondisparagement provision, but will not include a release of any rights or claims for indemnification Executive may have pursuant to any written indemnification agreement with the Company to which Executive is a party, the
Company’s bylaws, or applicable law (the “Release”) within the applicable deadline set forth therein and permitting the Release to become effective in accordance with its terms, which must occur no later than forty-five
(45) days following the date of termination (the “Release Deadline”). The salary continuation payments described in Section 8.2 will be paid in substantially equal installments on the Company’s regular payroll
schedule and subject to standard deductions and withholdings over the Severance Period following termination; provided, however, that no payments will be made prior to the effectiveness of the Release. On the effective date of the Release, the
Company will pay Executive the salary continuation payments that Executive would have received on or prior to such date in a lump sum under the original schedule but for the delay while waiting for the effectiveness of the release, with the balance
of the cash severance being paid as originally scheduled. 
 8.5 Definitions. For purposes of this Agreement: 

(i) “Cause” means, with respect to Executive, the occurrence of any of the following
events: (i) Executive’s commission of any felony or any crime involving fraud, dishonesty or moral turpitude under the laws of the United States or any state thereof; (ii) Executive’s attempted commission of, or participation in,
a fraud or act of dishonesty against the Company; (iii) Executive’s intentional, material violation of any contract or agreement between Executive and the Company or of any statutory duty owed to the Company that has not been cured, if
curable, within fifteen (15) days after written notice from the Board of such violation; (iv) Executive’s unauthorized use or disclosure of the Company’s confidential information or trade secrets; or (v) Executive’s
gross misconduct that has not been cured, if curable, within fifteen (15) days after written notice from the Board requesting that the Executive cure such misconduct. 

  
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 (ii) “Disability” means the inability of a
Executive to engage in substantially gainful Company activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of
not less than twelve (12) months, and shall be determined by the Board on the basis of such medical evidence as the Board deems warranted under the circumstances. 

(iii) “Good Reason” means Executive’s resignation from employment with the Company (or
successor to the Company, if applicable) due to any of the following actions taken by the Company (or successor to the Company, if applicable) without Executive’s prior written consent thereto: (1) a material reduction in Executive’s
base salary, which the parties agree is a reduction of at least 10% of Executive’s base salary (unless pursuant to a salary reduction program applicable generally to the Company’s similarly situated employees); (2) a material reduction in
Executive’s authority, duties or responsibilities; (3) a relocation of Executive’s principal place of employment to a place that increases Executive’s one-way commute by more than fifty
(50) miles as compared to Executive’s then-current principal place of employment immediately prior to such relocation (excluding regular travel in the ordinary course of business); and (4) a breach of a material provision of this
Agreement by the Company. Notwithstanding the foregoing, in order to resign for Good Reason, Executive must provide written notice to the Company within thirty (30) days after the first occurrence of the event giving rise to Good Reason
setting forth the basis for Executive’s resignation and allow the Company at least thirty (30) days from receipt of such written notice to cure such event, and, if such event is not reasonably cured within such period, Executive’s
resignation from all positions Executive then holds with the Company is effective not later than thirty (30) days after the expiration of the cure period. 

8.6 Section 409A. It is intended that all of the benefits and other payments payable under this
Agreement satisfy, to the greatest extent possible, an exemption from the application of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations and other guidance thereunder and
any state law of similar effect (collectively “Section 409A”), and this Agreement will be construed to the greatest extent possible as consistent with those provisions, and to the extent not
so exempt, this Agreement (and any definitions hereunder) will be construed in a manner that complies with Section 409A, and any ambiguities herein shall be interpreted accordingly. Specifically, the benefits under this Agreement are intended
to satisfy the exemptions from application of Section 409A provided under Treasury Regulations Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9) and each installment of severance benefits is a separate “payment” for purposes of Treasury Regulations Section 1.409A-2(b)(2)(i). However, if
such exemptions are not available and Executive is, upon Separation from Service, a “specified employee” for purposes of Section 409A, then, solely to the extent necessary to avoid adverse personal tax consequences under
Section 409A, the timing of the severance benefits payments shall be delayed until the earlier of (i) six (6) months and one day after Executive’s Separation from Service, or (ii) Executive’s death. Severance benefits shall
not commence until Executive has a Separation from Service. If the severance benefits are not covered by one or more exemptions from the application of Section 409A and the Release could become effective in the calendar year following the
calendar year in which Executive’s Separation from Service occurs, the Release will not be deemed effective, for purposes of payment of severance, any earlier than the Release Deadline. Except to the minimum extent that payments must be delayed
because Executive is a “specified employee” or until the effectiveness of the Release, all 

  
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severance amounts will be paid as soon as practicable in accordance with the Company’s normal payroll practices. 

8.7 Section 280G. If any payment or benefit Executive will or may receive from the Company or
otherwise (a “Payment”) would (i) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this sentence, be subject to the excise tax imposed by
Section 4999 of the Code (the “Excise Tax”), then such Payment will be equal to the Reduced Amount (defined below). The “Reduced Amount” will be either (l) the largest portion of the Payment
that would result in no portion of the Payment (after reduction) being subject to the Excise Tax or (2) the entire Payment, whichever amount after taking into account all applicable federal, state and local employment taxes, income taxes, and
the Excise Tax (all computed at the highest applicable marginal rate, net of the maximum reduction in federal income taxes which could be obtained from a deduction of such state and local taxes), results in Executive’s receipt, on an after-tax basis, of the greatest amount of the Payment. If a reduction in the Payment is to be made so that the Payment equals the Reduced Amount, (x) the Payment will be paid only to the extent permitted under
the Reduced Amount alternative, and the Executive will have no rights to any additional payments and/or benefits constituting the Payment, and (y) reduction in payments and/or benefits will occur in the following order: (1) reduction of
cash payments; (2) cancellation of accelerated vesting of equity awards other than stock options; (3) cancellation of accelerated vesting of stock options; and (4) reduction of other benefits paid to Executive. In the event that
acceleration of vesting of equity award compensation is to be reduced, such acceleration of vesting will be cancelled in the reverse order of the date of grant of Executive’s equity awards. In no event will the Company or any stockholder be
liable to Executive for any amounts not paid as a result of the operation of this Section. The professional firm engaged by the Company for general tax purposes as of the day prior to the effective date of the change in control will perform the
foregoing calculations. If the tax firm so engaged by the Company is serving as accountant or auditor for the acquirer, the Company will appoint a nationally recognized tax firm to make the determinations required hereunder. The Company will bear
all expenses with respect to the determinations by such firm required to be made hereunder. If the tax firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it will
furnish the Company and Executive with documentation that no Excise Tax is reasonably likely to be imposed with respect to such Payment. Any good faith determinations of the tax firm made hereunder will be final, binding and conclusive upon the
Company and Executive. 
 9. Dispute Resolution. To ensure the rapid and economical resolution of disputes that may
arise in connection with Executive’s employment with the Company, Executive and the Company agree that any and all disputes, claims, or causes of action, in law or equity, including but not limited to statutory claims, arising from or relating
to the enforcement, breach, performance, or interpretation of this Agreement, Executive’s employment with the Company, or the termination of Executive’s employment from the Company, will be resolved pursuant to the Federal Arbitration Act,
9 U.S.C. §1-16, and to the fullest extent permitted by law, by final, binding and confidential arbitration conducted in San Diego, California by JAMS, Inc. (“JAMS”) or its
successors, under JAMS’ then applicable rules and procedures for employment disputes (which can be found at http://www.jamsadr.com/rules-clauses/, and which will be provided to Executive on request); provided that the arbitrator shall:
(a) have the authority to compel adequate discovery for the resolution of the dispute and to award such relief as would otherwise be permitted by law; and (b) issue a written arbitration decision including the arbitrator’s essential
findings and 

  
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conclusions and a statement of the award. Executive and the Company shall be entitled to all rights and remedies that either would be entitled to pursue in a court of law. Both Executive and
the Company acknowledge that by agreeing to this arbitration procedure, they waive the right to resolve any such dispute through a trial by jury or judge or administrative proceeding. The Company shall pay all filing fees in excess of those
which would be required if the dispute were decided in a court of law, and shall pay the arbitrator’s fee. Nothing in this Agreement is intended to prevent either the Company or Executive from obtaining injunctive relief in court to prevent
irreparable harm pending the conclusion of any such arbitration. 
 Executive’s initials for
Section 9:     
 10. General Provisions. 

10.1 Notices. Any notices provided must be in writing and will be deemed effective upon the earlier of personal
delivery (including personal delivery by fax) or the next day after sending by overnight carrier, to the Company at its primary office location and to Executive at the address as listed on the Company payroll. 

10.2 Severability. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be
effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability
will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction to the extent possible in keeping with the intent of the Parties. 

10.3 Waiver. Any waiver of any breach of any provisions of this Agreement must be in writing to be effective, and it
shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 

10.4 Complete Agreement. This Agreement, together with the Proprietary Agreement, and the Indemnification Agreement
attached hereto as EXHIBIT B, constitutes the entire agreement between Executive and the Company with regard to the subject matter hereof and is the complete, final, and exclusive embodiment of the Company’s and
Executive’s agreement with regard to this subject matter. This Agreement is entered into without reliance on any promise or representation, written or oral, other than those expressly contained herein, and it supersedes any other such promises,
warranties or representations. It cannot be modified or amended except in a writing signed by a duly authorized officer of the Company, with the exception of those changes expressly reserved to the Company’s discretion in this Agreement. 

10.5 Counterparts. This Agreement may be executed in separate counterparts, any one of which need not contain
signatures of more than one party, but both of which taken together will constitute one and the same Agreement. 
 10.6
Headings. The headings of the paragraphs hereof are inserted for convenience only and shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 

  
 9 

 10.7 Successors and Assigns. This Agreement is intended to bind and
inure to the benefit of and be enforceable by Executive and the Company, and their respective successors, assigns, heirs, executors and administrators, except that Executive may not assign any of Executive’s duties hereunder and Executive may
not assign any of Executive’s rights hereunder without the written consent of the Company, which shall not be withheld unreasonably. 

10.8 Tax Withholding. All payments and awards contemplated or made pursuant to this Agreement will be subject to
withholdings of applicable taxes in compliance with all relevant laws and regulations of all appropriate government authorities. Executive acknowledges and agrees that the Company has neither made any assurances nor any guarantees concerning the tax
treatment of any payments or awards contemplated by or made pursuant to this Agreement. Executive has had the opportunity to retain a tax and financial advisor and fully understands the tax and economic consequences of all payments and awards made
pursuant to the Agreement. 
 10.9 Choice of Law. All questions concerning the construction, validity and
interpretation of this Agreement will be governed by the laws of the State of California. 
 [Signature Page Follows] 

  
 10 

 IN WITNESS
WHEREOF, the parties have executed this Agreement on the date first written above. 
  

			
	 METACRINE, INC.

		
	 By:
	 	 /s/ Richard A. Heyman

		 	 Richard A. Heyman, Ph.D.

		 	 Chairman of the Board

  

	
	 EXECUTIVE

	
	 /s/ Preston S. Klassen

	 Preston S. Klassen, MD, MHS

  
 11 

 EXHIBIT A 

PROPRIETARY AGREEMENT 

  
 12 

 EXHIBIT B 

INDEMNIFICATION AGREEMENT 

  
 13

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