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                                                                  EXHIBIT 10.79

                              [COMPANY LETTERHEAD]

January 16, 2001

Mr. Emile Loria
31 rue du Dr Jean Arlaud
31500 Toulouse, France

RE: EMPLOYMENT TERMS

Dear Emile:

EPIMMUNE INC. (the "Company") is pleased to offer you the position of President
and Chief Executive Officer, pursuant to the terms of this letter agreement
("Agreement") and contingent upon obtaining satisfactory approval of your right
to work in the United States.

1.      BOARD OF DIRECTORS

The Company agrees that it will nominate you as a member of the Board of
Directors and recommend that you be elected as a member of the Board of
Directors following your acceptance of this Agreement and prior to commencement
of employment with the Company. In the event, however, that you are unable for
any reason to commence employment within six (6) months of the date of this
Agreement, you agree that you shall immediately resign your position as a member
of the Board of Directors.

2.      DUTIES

Upon commencement of employment, you will be expected to do and perform all
services, acts or things necessary or advisable to manage and conduct the
business of the Company, including those duties normally associated with the
position of President and Chief Executive Officer. You will report to the
Company's Board of Directors, unless otherwise assigned by the Company. You will
work at our facility located in San Diego, California.

3.      BASE SALARY/BENEFITS

Upon commencement of employment, your base salary will be three hundred thousand
dollars (US$300,000) per year, less payroll deductions and all required
withholdings. Your base salary shall be prorated for any partial year of
employment on the basis of a 365-day fiscal year. You will be paid in regular
periodic payments in accordance with Company policy, but in no event less
frequent than semi-monthly. You will also be eligible for the standard Company
benefits, including medical insurance, vacation, sick leave and holidays.
Details about these benefit plans

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are available for your review. The Company may modify your compensation and
benefits from time to time as it deems necessary.

4.      LOYAL AND CONSCIENTIOUS PERFORMANCE

During your employment with the Company, you agree that you shall devote your
full business energies, interests, abilities and productive time to the proper
and efficient performance of your duties to the Company; provided that, you
shall not be precluded from engaging in civic, charitable or religious
activities or from serving on Boards of Directors of companies or organizations
which do not present any conflict of interest with the Company or effect your
performance of duties for the Company.

5.      BONUS

In addition to your base salary following commencement of employment, you will
be eligible to earn a performance bonus ("Bonus") equal to two percent (2%) of
any proceeds received by the Company from any public or private equity financing
completed by the Company during the first twelve (12) months of your employment.
In the event that you become eligible for this Bonus, you may elect to receive
the Bonus as either (i) a cash payment or (ii) a number of shares of the equity
security sold in the financing equal to the amount of the Bonus divided by the
per share price at which the equity was sold or (iii) any combination of cash
and stock you choose. Bonus payments will be awarded within a reasonable period
of time following the receipt of financing proceeds.

6.      RELOCATION

Upon commencement of employment, the Company agrees that it will provide you
with the following payments and reimbursements ("Relocation Benefits"):

        (a) Actual and reasonable cost of moving household goods from France to
San Diego, California;

        (b) Actual and reasonable temporary furnished living accommodations in
San Diego for up to six months;

        (c) Actual and reasonable automobile rental costs in San Diego for up to
six months;

        (d) Actual and reasonable cost of up to three trips for you and your
family to and from France as necessary to facilitate a smooth relocation
transition.

The Company also agrees that it will pay you US$60,000, less applicable
deductions and withholdings, to assist you with your relocation to San Diego,
California (the "Relocation Payment"). The Relocation Payment shall be a lump
sum payment that may be used by you in your sole discretion for expenses
associated with your move, including real estate brokerage fees and closing
costs. If you remain with the Company for twelve months from the date on which
your employment begins, you shall have no obligation to repay the Relocation
Payment. If you

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resign or the Company terminates you for Cause (as herein defined) within twelve
months of the date on which your employment begins, you agree to repay to the
Company 50% of the Relocation Payment. In the event that you become obligated to
repay 50% of the Relocation Payment, you agree that the Company may deduct such
amount from your final paycheck.

Reimbursements and payments to you under this section may be reported as
compensation to you and may be subject to state and/or federal taxation. If you
have questions regarding the tax implications, you should consult with your own
tax advisor.

7.      STOCK

Upon your election to the Board of Directors, the Company will sell to you, and
you agree to purchase, shares of common stock in an amount equal to 10% of the
outstanding shares of common stock on a fully diluted basis (including
conversion of Preferred Stock and exercise of currently outstanding Stock
Options), at a price equal to the fair market value of such stock on the date of
purchase (as determined by the closing price of such stock as reported on an
established stock exchange and as reported in The Wall Street Journal or such
other source as determined by the Board) (the "Shares"). The Shares shall be
subject to the terms of a restricted stock purchase agreement containing a
repurchase option in favor of the Company. The repurchase option will lapse
ratably each day over a four-year period beginning with your purchase date
provided that you remain in the continuous service of the Company. You agree to
pay for the Shares with a promissory note, secured by the Shares and payable in
four years from the date of purchase (the "Note"). With respect to each
indivisible share of stock under the Shares purchased with the proceeds of the
Note, you shall be personally liable for repayment of 50% of the amounts due
under the Note, and shall not be personally liable for repayment of the
remaining 50% of the amounts due under the Note. If you accept this Agreement,
you agree and understand that in connection with purchasing the Shares you will
be required to sign certain documents including, but not limited to, a
promissory note, stock pledge agreement, restricted stock purchase agreement,
joint escrow instructions and assignment separate from certificate.

8.      TERMINATION

The Company may terminate your employment at any time and for any or no reason,
with or without Cause (as defined herein) or advance notice by giving you
written notice of such termination. Similarly, you may terminate your employment
with the Company at any time at your election, in your sole discretion, for any
or no reason upon thirty (30) days notice to the Company, during which time you
shall provide reasonable transition assistance to the Company.

Notwithstanding the at-will nature of the employment relationship, if the
Company terminates your employment without Cause (as defined herein) or if you
resign from the Company for Good Reason (as defined herein), then upon your
furnishing to the Company an executed release and waiver of claims (a form of
which is attached hereto as Exhibit A): 1) you shall be entitled to receive
severance payments in the form of continuation of your base salary in effect at
the time of your termination, subject to standard payroll deductions and
withholdings, for twelve (12) months (the "Severance Period"). If you
voluntarily resign without Good Reason (as defined herein) or your employment is
terminated for Cause (as defined herein), all compensation and

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benefits will cease immediately and you will receive no additional payments from
the Company other than your accrued base salary and accrued and unused vacation
benefits earned through the date of your termination.

For purposes of this Agreement, "Cause" shall mean (i) willful misconduct by you
including, but not limited to, dishonesty which materially and adversely
reflects upon your ability to perform your duties for the Company, (ii) your
conviction of, or the entry of a pleading of guilty or nolo contendere by you
to, any crime involving moral turpitude or any felony, (iii) fraud, embezzlement
or theft against the Company, (iv) a material breach by you of any material
provision of the Proprietary Information and Inventions Agreement between you
and the Company (a copy of which is attached hereto as Exhibit B), or (v) your
willful and habitual failure to attend to your duties as assigned by the Board
of Directors or officers of the Company to whom you report and, in the case of
clauses (iv) and (v) above, which breach, misconduct or non-performance is not
cured by you within thirty (30) days after you receive written notice from the
Company of such breach, misconduct or non-performance.

For purposes of this Agreement, "Good Reason" shall mean termination by you of
your employment with the Company upon not less than thirty (30) days' prior
written notice to the Company (to allow the Company to remedy any basis for Good
Reason termination) as a result of (i) a substantial diminution in the scope of
your duties and authority within the Company which results in the assignment of
duties and responsibilities of materially lesser status, dignity and character
than your duties and responsibilities on the date of execution of this
Agreement, which is not the result of your failure to attend to and/or
successfully complete your duties and responsibilities, (ii) any reduction in
your base salary as initially set forth herein or as may be increased from time
to time, or (iii) relocation of your office, without your consent, to a location
that is more than thirty (30) miles from the Company's current corporate
headquarters.

9.      CHANGE IN CONTROL

If your employment is terminated by the Company or its successor Company without
Cause (as defined herein) or if you resign from the Company for Good Reason (as
defined herein) following a Change in Control (as defined herein), then upon
your furnishing to the Company an executed release and waiver of claims (a form
of which is attached hereto as Exhibit A): (i) the vesting of the Shares will be
immediately accelerated such that one hundred percent (100%) of the Shares will
be vested as of the Effective Date of the release and waiver attached hereto as
Exhibit A, and (ii) you will receive a lump sum payment equivalent to one year
of base salary, less applicable deductions and withholdings.

For purposes of this Agreement, "Change in Control" is defined as follows: (i) a
dissolution or liquidation of the Company; (ii) a sale or other disposition of
all or substantially all of the assets of the Company; (iii) a merger or
consolidation in which the Company is not the surviving corporation and in which
beneficial ownership of securities of the Company representing at least fifty
percent (50%) of the combined voting power entitled to vote in the election of
Directors has changed; (iv) an acquisition by any person, entity or group within
the meaning of Section 13(d) or 14(d) of the Securities Exchange Act, or any
comparable successor provisions (excluding any employee benefit plan, or related
trust, sponsored or maintained by the Company or subsidiary of

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the Company or other entity controlled by the Company) of the beneficial
ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act,
or comparable successor rule) of securities of the Company representing at least
fifty percent (50%) of the combined voting power entitled to vote in the
election of Directors.

In the event that any payments and other benefits provided for in this Agreement
or otherwise payable to you (the "Benefits") would (i) constitute "parachute
payments" within the meaning of Section 280G of the Internal Revenue Code of
1986, as amended (the "Code"), and (ii) but for this subsection would be subject
to the excise tax imposed by Section 4999 of the Code (the "Excise Tax"), then,
the Benefits to which you are entitled pursuant to this Agreement shall be
either:

        (a) Provided to you in full, or

        (b) Provided to you at such lesser extent that would result in no
portion of the Benefits being subject to the Excise Tax,

whichever of the foregoing amounts, when taking into account applicable federal,
state, local and foreign income and employment taxes, the Excise Tax, and any
other applicable taxes, results in the receipt by you, on an after tax basis, of
the greatest amount of the Benefits, notwithstanding that all or some portion of
the Benefits may be taxable under the Excise Tax. Unless you and the Company
otherwise agree in writing, any determination required under this subsection
shall be made in writing in good faith by an accountant selected by you. In the
event of a reduction of the Benefits under this Agreement, you shall be given
the choice of which of the Benefits to reduce. For purposes of making the
calculations required by this subsection, the accountant that you select may
make reasonable assumptions and approximations concerning applicable taxes and
may rely on reasonable, good faith interpretations concerning the application of
the Code, and other applicable legal authority. You and the Company shall
furnish your accountant such information and documents as he may reasonably
request in order to make a determination under this subsection.

Any payment and benefits received by you upon a Change in Control shall be in
lieu of any other severance payment to you, including the severance payment
provided in subsection 7 herein. In the event that you become entitled to
payment and benefits upon a Change in Control, the Company shall have no further
obligation to pay you any base salary, bonus or other compensation or benefits
under this Agreement, except for benefits due to you (or your dependents) under
the terms of your benefit plans.

10.     COMPANY POLICY

As a Company employee, you will be expected to abide by Company rules and
regulations and acknowledge in writing that you have read the Company's Employee
Handbook, which further will govern the terms and conditions of your employment.
The Company's Employee Handbook may be modified from time to time at the sole
discretion of the Company.

11.     PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT

As a condition of employment, you will be required to sign and comply with the
Proprietary Information and Inventions Agreement attached hereto as Exhibit B,
which prohibits unauthorized use or disclosure of the Company's proprietary
information, among other things.

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In your work for the Company, you will be expected not to use or disclose any
confidential information, including trade secrets, of any former employer or
other person to whom you have an obligation of confidentiality. Rather, you will
be expected to use only that information which is generally known and used by
persons with training and experience comparable to your own, which is common
knowledge in the industry or otherwise legally in the public domain, or which is
otherwise provided or developed by the Company. During our discussions about
your proposed job duties, you assured us that you would be able to perform those
duties within the guidelines just described. Accordingly, you agree that you
will not bring onto Company premises any unpublished documents or property
belonging to any former employer or other person to whom you have an obligation
of confidentiality.

12.     ENTIRE AGREEMENT

This Agreement, together with your Proprietary Information and Inventions
Agreement and the stock documents referred to herein, forms the complete and
exclusive statement of the terms of your employment with the Company. The
employment terms in this Agreement supersede any other agreements or promises
made to you by anyone, whether oral or written.

13.     GOVERNING LAW

This Agreement will be governed by and construed according to the laws of the
State of California. You hereby expressly consent to the personal jurisdiction
of the state and federal courts located in San Diego, California for any lawsuit
filed there against you by the Company arising from or related to this
Agreement.

14.     SUCCESSORS AND ASSIGNS.

This Agreement will be binding upon your heirs, executors, administrators and
other legal representatives and will be for the benefit of the Company, its
successors, and its assigns.

As required by law, this offer is subject to satisfactory proof of your right to
work in the United States. Please sign and date this Agreement, and return it to
me by January 19, 2001, if you wish to accept employment with the Company under
the terms described above. If you accept our offer, we will expect you to
commence employment promptly upon receipt of authorization to work in the United
States. In the event that you are unable to begin work with the Company for any
reason after six (6) months from the date of the Agreement, the Agreement shall
become void and of no further force and effect, unless otherwise agreed to in
writing by you and the Company.

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We look forward to your favorable reply and to a productive and enjoyable work
relationship.

Sincerely,

/s/ Howard E. Greene, Jr.
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HOWARD E. GREENE, JR.
CHAIRMAN OF THE BOARD OF DIRECTORS

Accepted:

/s/ Emile Loria
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EMILE LORIA

January 16, 2001
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Date

Attachment:   Exhibit A:  Waiver and Release
              Exhibit B.  Proprietary Information and Inventions Agreement

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                                    EXHIBIT A

                          RELEASE AND WAIVER OF CLAIMS

        In consideration of the payments and other benefits set forth in the
Agreement dated ___________, to which this form is attached, I, EMILE LORIA,
hereby furnish EPIMMUNE INC. (the "Company"), with the following release and
waiver ("Release and Waiver").

        I hereby release, and forever discharge the Company, its officers,
directors, agents, employees, stockholders, successors, assigns affiliates and
Benefit Plans, of and from any and all claims, liabilities, demands, causes of
action, costs, expenses, attorneys' fees, damages, indemnities and obligations
of every kind and nature, in law, equity, or otherwise, known and unknown,
suspected and unsuspected, disclosed and undisclosed, arising at any time prior
to and including my employment Termination Date, including, but not limited to
any claims relating to my employment and the termination of my employment,
including but not limited to, claims pursuant to any federal, state or local law
relating to employment, including, but not limited to, discrimination claims,
claims under the California Fair Employment and Housing Act, and the Federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"), or claims for
wrongful termination, breach of the covenant of good faith, contract claims,
tort claims, and wage or benefit claims, including but not limited to, claims
for salary, bonuses, commissions, stock, stock options, vacation pay, fringe
benefits, severance pay or any form of compensation.

        I also acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A GENERAL RELEASE DOES NOT EXTEND
TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT
THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY
AFFECTED HIS SETTLEMENT WITH THE DEBTOR." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to any claims I may have against the
Company.

        I acknowledge that, among other rights, I am waiving and releasing any
rights I may have under ADEA, that this Release and Waiver is knowing and
voluntary, and that the consideration given for this Release and Waiver is in
addition to anything of value to which I was already entitled as an executive of
the Company. I further acknowledge that I have been advised, as required by the
Older Workers Benefit Protection Act, that: (a) the Release and Waiver granted
herein does not relate to claims which may arise after this Release and Waiver
is executed; (b) I have the right to consult with an attorney prior to executing
this Release and Waiver (although I may choose voluntarily not to do so); and if
I am over 40 years of age upon execution of this Release and Waiver: (c) I have
twenty-one (21) days from the date of termination of my employment with the
Company in which to consider this Release and Waiver (although I may choose
voluntarily to execute this Release and Waiver earlier); (d) I have seven (7)
days following the execution of this Release and Waiver to revoke my consent to
this Release and Waiver; and (e) this Release and Waiver shall not be effective
until the seven (7) day revocation period has expired.

Date:                                            By: /s/ Emile Loria
                                                     --------------------------
                                                     EMILE LORIA

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                                    EXHIBIT B

                                  EPIMMUNE INC.

            EMPLOYEE PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT

        In consideration of my employment or continued employment by EPIMMUNE
INC. (the "Company"), and the compensation now and hereafter paid to me, I
hereby agree as follows:

1.      NONDISCLOSURE

        1.1 RECOGNITION OF COMPANY'S RIGHTS; NONDISCLOSURE. At all times during
my employment and thereafter, I will hold in strictest confidence and will not
disclose, use, lecture upon or publish any of the Company's Proprietary
Information (defined below), except as such disclosure, use or publication may
be required in connection with my work for the Company, or unless an officer of
the Company expressly authorizes such in writing. I will obtain Company's
written approval before publishing or submitting for publication any material
(written, verbal, or otherwise) that relates to my work at Company and/or
incorporates any Proprietary Information. I hereby assign to the Company any
rights I may have or acquire in such Proprietary Information and recognize that
all Proprietary Information shall be the sole property of the Company and its
assigns.

        1.2 PROPRIETARY INFORMATION. The term "PROPRIETARY INFORMATION" shall
mean any and all confidential and/or proprietary knowledge, data or information
of the Company. By way of illustration but not limitation, "PROPRIETARY
INFORMATION" includes (a) trade secrets, inventions, mask works, ideas,
processes, formulas, source and object codes, data, programs, other works of
authorship, know-how, improvements, discoveries, developments, designs and
techniques (hereinafter collectively referred to as "INVENTIONS"); and (b)
information regarding plans for research, development, new products, marketing
and selling, business plans, budgets and unpublished financial statements,
licenses, prices and costs, suppliers and customers; and (c) information
regarding the skills and compensation of other employees of the Company.
Notwithstanding the foregoing, it is understood that, at all such times, I am
free to use information which is generally known in the trade or industry, which
is not gained as result of a breach of this Agreement, and my own, skill,
knowledge, know-how and experience to whatever extent and in whichever way I
wish.

        1.3 THIRD PARTY INFORMATION. I understand, in addition, that the Company
has received and in the future will receive from third parties confidential or
proprietary information ("THIRD PARTY INFORMATION") subject to a duty on the
Company's part to maintain the confidentiality of such information and to use it
only for certain limited purposes. During the term of my employment and
thereafter, I will hold Third Party Information in the strictest confidence and
will not disclose to anyone (other than Company personnel who need to know such
information in connection with their work for the Company) or use, except in
connection with my work for the Company, Third Party Information unless
expressly authorized by an officer of the Company in writing.

        1.4 NO IMPROPER USE OF INFORMATION OF PRIOR EMPLOYERS AND OTHERS. During
my employment by the Company I will not improperly use or

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disclose any confidential information or trade secrets, if any, of any former
employer or any other person to whom I have an obligation of confidentiality,
and I will not bring onto the premises of the Company any unpublished documents
or any property belonging to any former employer or any other person to whom I
have an obligation of confidentiality unless consented to in writing by that
former employer or person. I will use in the performance of my duties only
information which is generally known and used by persons with training and
experience comparable to my own, which is common knowledge in the industry or
otherwise legally in the public domain, or which is otherwise provided or
developed by the Company.

2.      ASSIGNMENT OF INVENTIONS.

        2.1 PROPRIETARY RIGHTS. The term "PROPRIETARY RIGHTS" shall mean all
trade secret, patent, copyright, mask work and other intellectual property
rights throughout the world.

        2.2 PRIOR INVENTIONS. Inventions, if any, patented or unpatented, which
I made prior to the commencement of my employment with the Company are excluded
from the scope of this Agreement. To preclude any possible uncertainty, I have
set forth on Exhibit B (Previous Inventions) attached hereto a complete list of
all Inventions that I have, alone or jointly with others, conceived, developed
or reduced to practice or caused to be conceived, developed or reduced to
practice prior to the commencement of my employment with the Company, that I
consider to be my property or the property of third parties and that I wish to
have excluded from the scope of this Agreement (collectively referred to as
"PRIOR INVENTIONS"). If disclosure of any such Prior Invention would cause me to
violate any prior confidentiality agreement, I understand that I am not to list
such Prior Inventions in Exhibit B but am only to disclose a cursory name for
each such invention, a listing of the party(ies) to whom it belongs and the fact
that full disclosure as to such inventions has not been made for that reason. A
space is provided on Exhibit B for such purpose. If no such disclosure is
attached, I represent that there are no Prior Inventions. If, in the course of
my employment with the Company, I incorporate a Prior Invention into a Company
product, process or machine, the Company is hereby granted and shall have a
nonexclusive, royalty-free, irrevocable, perpetual, worldwide license (with
rights to sublicense through multiple tiers of sublicensees) to make, have made,
modify, use and sell such Prior Invention. Notwithstanding the foregoing, I
agree that I will not incorporate, or permit to be incorporated, Prior
Inventions in any Company Inventions without the Company's prior written
consent.

        2.3 ASSIGNMENT OF INVENTIONS. Subject to Sections 2.4, and 2.6, I hereby
assign and agree to assign in the future (when any such Inventions or
Proprietary Rights are first reduced to practice or first fixed in a tangible
medium, as applicable) to the Company all my right, title and interest in and to
any and all Inventions (and all Proprietary Rights with respect thereto) whether
or not patentable or registrable under copyright or similar statutes, made or
conceived or reduced to practice or learned by me, either alone or jointly with
others, during the period of my employment with the Company. Inventions assigned
to the Company, or to a third party as directed by the Company pursuant to this
Section 2, are hereinafter referred to as "COMPANY INVENTIONS."

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        2.4 NONASSIGNABLE INVENTIONS. This Agreement does not apply to an
Invention which qualifies fully as a nonassignable Invention under Section 2870
of the California Labor Code (hereinafter "SECTION 2870"). I have reviewed the
notification on Exhibit A (Limited Exclusion Notification) and agree that my
signature acknowledges receipt of the notification.

        2.5 OBLIGATION TO KEEP COMPANY INFORMED. During the period of my
employment and for six (6) months after termination of my employment with the
Company, I will promptly disclose to the Company fully and in writing all
Inventions authored, conceived or reduced to practice by me, either alone or
jointly with others. In addition, I will promptly disclose to the Company all
patent applications filed by me or on my behalf within a year after termination
of employment. At the time of each such disclosure, I will advise the Company in
writing of any Inventions that I believe fully qualify for protection under
Section 2870; and I will at that time provide to the Company in writing all
evidence necessary to substantiate that belief. The Company will keep in
confidence and will not use for any purpose or disclose to third parties without
my consent any confidential information disclosed in writing to the Company
pursuant to this Agreement relating to Inventions that qualify fully for
protection under the provisions of Section 2870. I will preserve the
confidentiality of any Invention that does not fully qualify for protection
under Section 2870.

        2.6 GOVERNMENT OR THIRD PARTY. I also agree to assign all my right,
title and interest in and to any particular Company Invention to a third party,
including without limitation the United States, as directed by the Company.

        2.7 WORKS FOR HIRE. I acknowledge that all original works of authorship
which are made by me (solely or jointly with others) within the scope of my
employment and which are protectable by copyright are "works made for hire,"
pursuant to United States Copyright Act (17 U.S.C., Section 101).

        2.8 ENFORCEMENT OF PROPRIETARY RIGHTS. I will assist the Company in
every proper way to obtain, and from time to time enforce, United States and
foreign Proprietary Rights relating to Company Inventions in any and all
countries. To that end I will execute, verify and deliver such documents and
perform such other acts (including appearances as a witness) as the Company may
reasonably request for use in applying for, obtaining, perfecting, evidencing,
sustaining and enforcing such Proprietary Rights and the assignment thereof. In
addition, I will execute, verify and deliver assignments of such Proprietary
Rights to the Company or its designee. My obligation to assist the Company with
respect to Proprietary Rights relating to such Company Inventions in any and all
countries shall continue beyond the termination of my employment, but the
Company shall compensate me at a reasonable rate after my termination for the
time actually spent by me at the Company's request on such assistance.

In the event the Company is unable for any reason, after reasonable effort, to
secure my signature on any document needed in connection with the actions
specified in the preceding paragraph, I hereby irrevocably designate and appoint
the Company and its duly authorized officers and agents as my agent and attorney
in fact, which appointment is coupled with an interest, to act for and in my
behalf to execute, verify and file any such documents and to do all other
lawfully permitted acts to further the purposes of the

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preceding paragraph with the same legal force and effect as if executed by me. I
hereby waive and quitclaim to the Company any and all claims, of any nature
whatsoever, which I now or may hereafter have for infringement of any
Proprietary Rights assigned hereunder to the Company.

        3. RECORDS. I agree to keep and maintain adequate and current records
(in the form of notes, sketches, drawings and in any other form that may be
required by the Company) of all Proprietary Information developed by me and all
Inventions made by me during the period of my employment at the Company, which
records shall be available to and remain the sole property of the Company at all
times.

        4. ADDITIONAL ACTIVITIES. I agree that during the period of my
employment by the Company I will not, without the Company's express written
consent, engage in any employment or business activity which is competitive
with, or would otherwise conflict with, my employment by the Company. I agree
further that for the period of my employment by the Company and for one (l) year
after the date of termination of my employment by the Company I will not induce
any employee of the Company to leave the employ of the Company.

        5. NO CONFLICTING OBLIGATION. I represent that my performance of all the
terms of this Agreement and as an employee of the Company does not and will not
breach any agreement to keep in confidence information acquired by me in
confidence or in trust prior to my employment by the Company. I have not entered
into, and I agree I will not enter into, any agreement either written or oral in
conflict herewith.

        6. RETURN OF COMPANY DOCUMENTS. When I leave the employ of the Company,
I will deliver to the Company any and all drawings, notes, memoranda,
specifications, devices, formulas, and documents, together with all copies
thereof, and any other material containing or disclosing any Company Inventions,
Third Party Information or Proprietary Information of the Company. I further
agree that any property situated on the Company's premises and owned by the
Company, including disks and other storage media, filing cabinets or other work
areas, is subject to inspection by Company personnel at any time with or without
notice. Prior to leaving, I will cooperate with the Company in completing and
signing the Company's termination statement.

        7. LEGAL AND EQUITABLE REMEDIES. Because my services are personal and
unique and because I may have access to and become acquainted with the
Proprietary Information of the Company, the Company shall have the right to
enforce this Agreement and any of its provisions by injunction, specific
performance or other equitable relief, without bond and without prejudice to any
other rights and remedies that the Company may have for a breach of this
Agreement.

        8. NOTICES. Any notices required or permitted hereunder shall be given
to the appropriate party at the address specified below or at such other address
as the party shall specify in writing. Such notice shall be deemed given upon
personal delivery to the appropriate address or if sent by certified or
registered mail, three (3) days after the date of mailing.

        9. NOTIFICATION OF NEW EMPLOYER. In the event that I leave the employ of
the Company, I hereby consent to the notification of my new employer of my
rights and obligations under this Agreement.

                                       4
<PAGE>   13

10.        GENERAL PROVISIONS.

           10.1 GOVERNING LAW; CONSENT TO PERSONAL JURISDICTION. This Agreement
will be governed by and construed according to the laws of the State of
California, as such laws are applied to agreements entered into and to be
performed entirely within California between California residents. I hereby
expressly consent to the personal jurisdiction of the state and federal courts
located in San Diego County, California for any lawsuit filed there against me
by Company arising from or related to this Agreement.

           10.2 SEVERABILITY. In case any one or more of the provisions
contained in this Agreement shall, for any reason, be held to be invalid,
illegal or unenforceable in any respect, such invalidity, illegality or
unenforceability shall not affect the other provisions of this Agreement, and
this Agreement shall be construed as if such invalid, illegal or unenforceable
provision had never been contained herein. If moreover, any one or more of the
provisions contained in this Agreement shall for any reason be held to be
excessively broad as to duration, geographical scope, activity or subject, it
shall be construed by limiting and reducing it, so as to be enforceable to the
extent compatible with the applicable law as it shall then appear.

           10.3 SUCCESSORS AND ASSIGNS. This Agreement will be binding upon my
heirs, executors, administrators and other legal representatives and will be for
the benefit of the Company, its successors, and its assigns.

           10.4 SURVIVAL. The provisions of this Agreement shall survive the
termination of my employment and the assignment of this Agreement by the Company
to any successor in interest or other assignee.

           10.5 EMPLOYMENT. I agree and understand that nothing in this
Agreement shall confer any right with respect to continuation of employment by
the Company, nor shall it interfere in any way with my right or the Company's
right to terminate my employment at any time, with or without cause.

           10.6 WAIVER. No waiver by the Company of any breach of this Agreement
shall be a waiver of any preceding or succeeding breach. No waiver by the
Company of any right under this Agreement shall be construed as a waiver of any
other right. The Company shall not be required to give notice to enforce strict
adherence to all terms of this Agreement.

           10.7 ENTIRE AGREEMENT. The obligations pursuant to Sections 1 and 2
of this Agreement shall apply to any time during which I was previously
employed, or am in the future employed, by the Company as a consultant if no
other agreement governs nondisclosure and assignment of inventions during such
period. This Agreement is the final, complete and exclusive agreement of the
parties with respect to the subject matter hereof and supersedes and merges all
prior discussions between us. No modification of or amendment to this Agreement,
nor any waiver of any rights under this Agreement, will be effective unless in
writing and signed by the party to be charged. Any subsequent change or changes
in my duties, salary or compensation will not affect the validity or scope of
this Agreement.

        This Agreement shall be effective as of the first day of my employment
with the Company, namely: _______________, 20__.

                                       5
<PAGE>   14

        I HAVE READ THIS AGREEMENT CAREFULLY AND UNDERSTAND ITS TERMS. I HAVE
COMPLETELY FILLED OUT EXHIBIT B TO THIS AGREEMENT.

Date: January 16, 2001
      --------------------------

/s/ Emile Loria
--------------------------------
(SIGNATURE)

Emile Loria
--------------------------------
(PRINTED NAME)

ACCEPTED AND AGREED TO:

EPIMMUNE INC.

By: /s/ Robert De Vaere
    ----------------------------

--------------------------------
Title:

--------------------------------
(Address)

--------------------------------
Dated:

--------------------------------
January 16, 2001

                                       6
<PAGE>   15

                                    EXHIBIT A

                         LIMITED EXCLUSION NOTIFICATION

        THIS IS TO NOTIFY you in accordance with Section 2872 of the California
Labor Code that the foregoing Agreement between you and the Company does not
require you to assign or offer to assign to the Company any invention that you
developed entirely on your own time without using the Company's equipment,
supplies, facilities or trade secret information except for those inventions
that either:

        1. Relate at the time of conception or reduction to practice of the
invention to the Company's business, or actual or demonstrably anticipated
research or development of the Company;

        2. Result from any work performed by you for the Company.

           To the extent a provision in the foregoing Agreement purports to
require you to assign an invention otherwise excluded from the preceding
paragraph, the provision is against the public policy of this state and is
unenforceable.

           This limited exclusion does not apply to any patent or invention
covered by a contract between the Company and the United States or any of its
agencies requiring full title to such patent or invention to be in the United
States.

        I ACKNOWLEDGE RECEIPT of a copy of this notification.

                                           By: /s/ Emile Loria
                                               --------------------------------
                                               (PRINTED NAME OF EMPLOYEE)

                                           Date:
                                                -------------------------------

WITNESSED BY:

-----------------------------------
(PRINTED NAME OF REPRESENTATIVE)

<PAGE>   16

                                    EXHIBIT B

TO:      EPIMMUNE INC.

FROM:    EMILE LORIA

DATE:
         --------------------

SUBJECT: PREVIOUS INVENTIONS

        1. Except as listed in Section 2 below, the following is a complete list
of all inventions or improvements relevant to the subject matter of my
employment by EPIMMUNE INC. (the "COMPANY") that have been made or conceived or
first reduced to practice by me alone or jointly with others prior to my
engagement by the Company:

        [ ]   No inventions or improvements.

        [ ]   See below:

              ------------------------------------------------------------------

              ------------------------------------------------------------------

              ------------------------------------------------------------------

        [ ]   Additional sheets attached.

        2. Due to a prior confidentiality agreement, I cannot complete the
disclosure under Section 1 above with respect to inventions or improvements
generally listed below, the proprietary rights and duty of confidentiality with
respect to which I owe to the following party(ies):

<TABLE>
<CAPTION>
       INVENTION OR IMPROVEMENT            PARTY(IES)            RELATIONSHIP
<S>                                        <C>                  <C>
1.
       ------------------------            ----------            ------------

2.
       ------------------------            ----------            ------------

3.
       ------------------------            ----------            ------------
</TABLE>

[ ]     Additional sheets attached.

                                        2<PAGE>   1

                                                                  Exhibit 10.80

                                  EPIMMUNE INC.
                            RESTRICTED STOCK PURCHASE

                                    AGREEMENT

        EPIMMUNE INC. (the "Company") wishes to sell to you, and you wish to
purchase, shares of the Company's Common Stock (the "Common Stock") from the
Company pursuant to the provisions of this Restricted Stock Purchase Agreement,
dated January 16, 2001 ("Agreement"). Certain capitalized terms in the Agreement
are defined on Exhibit A attached hereto.

        The parties hereto agree as follows:

        1. PURCHASE AND SALE OF STOCK. You hereby agree to purchase from the
Company, and the Company hereby agrees to sell to you, an aggregate of one
million fifty-six thousand three hundred one (1,056,301) shares of the Common
Stock of the Company (the "Stock") at two dollars and fifty cents (US $2.50) per
share (the "Price Per Share"), for an aggregate purchase price of two million
six hundred forty thousand seven hundred fifty-two dollars and fifty cents (US
$2,640,752.50), payable by promissory note.

        2. CLOSING. The closing hereunder, including payment for and delivery of
the Stock shall occur at the offices of the Company immediately following the
execution of this Agreement, or at such other time and place as the parties may
mutually agree. At the closing you shall deliver the following documents:

            (a) Two executed copies of the Assignment Separate From Certificate
(with date and number of shares blank) substantially in the form attached hereto
as Exhibit B and executed Joint Escrow Instructions substantially in the form
attached hereto as Exhibit C, along with the certificate or certificates
evidencing the Stock, for use by the Escrow Agent pursuant to the terms of the
Joint Escrow Instructions.

           (b) Promissory note in substantially the form attached hereto as
Exhibit D and an executed pledge agreement in substantially the form attached
hereto as Exhibit E (the "Pledge Agreement"), along with the certificate or
certificates evidencing the Stock, for use by the Escrow Agent pursuant to the
terms of the Joint Escrow Instructions.

        3. VESTING. Subject to the limitations contained herein, the Stock will
vest ratably in equal daily installments over a period of four (4) years from
the date of this Agreement such that one hundred percent (100%) of the Stock
will be vested at the end of such four (4) year period, provided that vesting
will cease upon the termination of your Continuous Service.

        4. RESTRICTIONS ON TRANSFER. You agree that the Company (or a
representative of the underwriters) may, in connection with an underwritten
registration of the offering of any securities of the Company under the
Securities Act, require that you not sell, dispose of, transfer, make any short
sale of, grant any option for the purchase of, or enter into any hedging or
similar transaction with the same economic effect as a sale, any shares of
Common Stock or other securities of the Company held by you under this
Agreement, for a period of time specified by

<PAGE>   2

the underwriter(s) (not to exceed one hundred eighty (180) days) following the
effective date of the registration statement of the Company filed under the
Securities Act. You further agree to execute and deliver such other agreements
as may be reasonably requested by the Company and/or the underwriter(s) that are
consistent with the foregoing or that are necessary to give further effect
thereto. In order to enforce the foregoing covenant, the Company may impose
stop-transfer instructions with respect to your Common Stock until the end of
such period.

        5. PURCHASE OPTION. The Company shall have the right (the "Purchase
Option") to purchase all or any part of the Stock received pursuant to this
Agreement that has not as yet vested in accordance with the vesting schedule set
forth in Section 3 of this Agreement ("Unvested Shares") on the following terms
and conditions:

           (a) The Company shall, simultaneously with termination of your
Continuous Service, purchase at the Price Per Share all of the Unvested Shares,
unless the Company agrees to waive its Purchase Option as to some or all of the
Unvested Shares. Any such waiver shall be exercised by the Company by written
notice to you or your representative (with a copy to the Escrow Agent) within
ninety (90) days after the termination of your Continuous Service, and the
Escrow Agent may then release to you the number of Unvested Shares not being
reacquired by the Company. If the Company does not waive its Purchase Option as
to all of the Unvested Shares, then upon such termination of your Continuous
Service, the Escrow Agent shall transfer to the Company the number of Unvested
Shares the Company is purchasing.

           (b) The Company shall pay for the purchase of any Unvested Shares
with respect to which it exercises its Purchase Option in cash or by
cancellation of purchase money indebtedness within ninety (90) days after the
termination of your Continuous Service.

           (c) The Stock issued under this Agreement shall be held in escrow
pursuant to the terms of the Joint Escrow Instructions attached hereto as
Exhibit C.

        6. ADJUSTMENTS TO STOCK. If, from time to time, during the term of the
Purchase Option there is any change affecting the Company's outstanding Common
Stock as a class that is effected without the receipt of consideration by the
Company (through merger, consolidation, reorganization, reincorporation, stock
dividend, dividend in property other than cash, stock split, liquidating,
dividend, combination of shares, change in corporation structure or other
transaction not involving the receipt of consideration by the Company), then any
and all new, substituted or additional securities or other property to which you
are entitled by reason of your ownership of Stock shall be immediately subject
to the Purchase Option and be included in the word "Stock" for all purposes of
the Purchase Option with the same force and effect as the shares of the Stock
presently subject to the Purchase Option, but only to the extent the Stock is,
at the time, covered by such Purchase Option. The Price Per Share of Stock upon
exercise of the Purchase Option shall be appropriately adjusted. The Company's
Board of Directors shall make such adjustments and its determination shall be
final, binding and conclusive (the conversion of any convertible securities of
the Company shall not be treated as a transaction "without receipt of
consideration" by the Company).

                                        2

<PAGE>   3

        7. CHANGE IN CONTROL.

           (a) In the event (a) your employment is terminated by the Company or
its successor without Cause or if you resign from the Company with Good Reason
following a Change in Control and (b) within ninety (90) days after the
termination of your employment with the Company you furnish to the Company or
its successor an executed release and waiver of claims in substantially the form
attached to your offer letter dated January 16, 2001, then the Purchase Option
shall terminate and all of the Stock subject to the Purchase Option shall be
fully vested and released from the Purchase Option.

           (b) In the event of a Change in Control, then the Purchase Option may
be assigned by the Company to any successor of the Company (or the successor's
parent) in connection with such Change in Control. To the extent that the
Purchase Option remains in effect following such a Change in Control, it shall
apply to the new capital stock or other property received in exchange for the
Stock in consummation of the Change in Control, but only to the extent the Stock
is at the time subject to such Purchase Option. Appropriate adjustments shall be
made to the Price Per Share payable upon exercise of the Purchase Option to
reflect the effect of the Change in Control upon the Company's capital
structure.

        8. PARACHUTE PAYMENTS. In the event that any payments and other benefits
provided for in this Agreement or otherwise payable to you (the "Benefits")
would (i) constitute "parachute payments" within the meaning of Section 280G of
the Internal Revenue Code of 1986, as amended (the "Code"), and (ii) but for
this subsection would be subject to the excise tax imposed by Section 4999 of
the Code (the "Excise Tax"), then, the Benefits to which you are entitled
pursuant to this Agreement shall be either:

           (a) Provided to you in full, or

           (b) Provided to you at such lesser extent that would result in no
portion of the Benefits being subject to the Excise Tax, whichever of the
foregoing amounts, when taking into account applicable federal, state, local and
foreign income and employment taxes, the Excise Tax, and any other applicable
taxes, results in the receipt by you, on an after tax basis, of the greatest
amount of the Benefits, notwithstanding that all or some portion of the Benefits
may be taxable under the Excise Tax. Unless you and the Company otherwise agree
in writing, any determination required under this subsection shall be made in
writing in good faith by an accountant selected by you. In the event of a
reduction of the Benefits under this Agreement, you shall be given the choice of
which of the Benefits to reduce. For purposes of making the calculations
required by this subsection, the accountant that you select may make reasonable
assumptions and approximations concerning applicable taxes and may rely on
reasonable, good faith interpretations concerning the application of the Code,
and other applicable legal authority. You and the Company shall furnish your
accountant such information and documents as he may reasonably request in order
to make a determination under this subsection.

                                        3

<PAGE>   4

           Any payment and benefits received by you upon a Change in Control
shall be in lieu of any other severance payment to you, including the severance
payment provided in subsection 7 herein. In the event that you become entitled
to payment and benefits upon a Change in Control, the Company shall have no
further obligation to pay you any base salary, bonus or other compensation or
benefits under this Agreement, except for benefits due to you (or your
dependents) under the terms of your benefit plans.

        9. RESTRICTIVE LEGENDS. The shares issued under this Agreement shall be
endorsed with appropriate legends determined by the Company, including but not
limited to the following legends:

        THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO AN OPTION SET
FORTH IN AN AGREEMENT BETWEEN THE COMPANY AND THE REGISTERED HOLDER, OR SUCH
HOLDER'S PREDECESSOR IN INTEREST, A COPY OF WHICH IS ON FILE AT THE PRINCIPAL
OFFICE OF THIS COMPANY. ANY TRANSFER OR ATTEMPTED TRANSFER OF ANY SHARES SUBJECT
TO SUCH OPTION IS VOID WITHOUT THE PRIOR EXPRESS WRITTEN CONSENT OF THE COMPANY.

        THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933 AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR
SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.

        10. INVESTMENT REPRESENTATIONS. In connection with the purchase of the
Stock, you represent to the Company the following:

            (a) You are aware of the Company's business affairs and financial
condition and have acquired sufficient information about the Company to reach an
informed and knowledgeable decision to acquire the Stock. You are purchasing the
Stock for investment for your own account only and not with a view to, or for
resale in connection with, any "distribution" thereof within the meaning of the
Securities Act.

            (b) You understand that the Stock has not been registered under the
Act by reason of a specific exemption therefrom, which exemption depends upon,
among other things, the bona fide nature of your investment intent as expressed
herein.

            (c) You further acknowledge and understand that the Stock must be
held indefinitely unless the Stock is subsequently registered under the
Securities Act or an exemption from such registration is available.

            (d) You are familiar with the provisions of Rule 144 under the Act,
as in effect from time to time, which, in substance, permit limited public
resale of "restricted securities" acquired, directly or indirectly, from the
issuer thereof (or from an affiliate of such

                                        4

<PAGE>   5

issuer), in a non-public offering subject to the satisfaction of certain
conditions. The Stock may be resold by you in certain limited circumstances
subject to the provisions of Rule 144, which requires, among other things: (i)
the availability of certain public information about the Company and (ii) the
resale occurring following the required holding period under Rule 144 after you
have purchased, and made full payment of (within the meaning of Rule 144), the
securities to be sold.

            (e) You further warrant and represent that you have either (i)
preexisting personal or business relationships, with the Company or any of its
officers, directors or controlling persons, or (ii) the capacity to protect your
own interests in connection with the purchase of the Stock by virtue of your
business or financial expertise or of your professional advisors who are
unaffiliated with and who are not compensated by the Company or any of its
affiliates, directly or indirectly.

        11. AGREEMENT NOT A SERVICE CONTRACT. This Agreement is not an
employment or service contract, and nothing in this Agreement shall be deemed to
create in any way whatsoever any obligation on your part to continue in the
employ of the Company or an Affiliate, or on the part of the Company or an
Affiliate to continue your employment. In addition, nothing in this Agreement
shall obligate the Company or an Affiliate, their respective stockholders,
boards of directors, Officers or Employees to continue any relationship that you
might have as a Director or Consultant for the Company or an Affiliate.

        12. WITHHOLDING OBLIGATIONS.

            (a) Upon the execution of this Agreement, or at any time thereafter
as requested by the Company, you hereby authorize withholding from payroll and
any other amounts payable to you, and otherwise agree to make adequate provision
for any sums required to satisfy the federal, state, local and foreign tax
withholding obligations of the Company or an Affiliate, if any, which arise in
connection with this Agreement.

            (b) Unless the tax withholding obligations of the Company and/or any
Affiliate are satisfied, the Company shall have no obligation to issue a
certificate for such shares or release such shares from any escrow provided for
herein.

        13. TAX CONSEQUENCES. The acquisition and vesting of the Stock may have
adverse tax consequences to you that may be avoided or mitigated by filing an
election under Section 83(b) of the Code. Such election must be filed within
thirty (30) days after the date you purchase the shares pursuant to this
Agreement. YOU ACKNOWLEDGE THAT IT IS YOUR OWN RESPONSIBILITY, AND NOT THE
COMPANY'S, TO FILE A TIMELY ELECTION UNDER CODE SECTION 83(B), EVEN IF YOU
REQUEST THE COMPANY TO MAKE THE FILING ON YOUR BEHALF.

        14. NOTICES. Any notices provided for in this Agreement shall be given
in writing and shall be deemed effectively given upon receipt or, in the case of
notices delivered by the Company to you, five (5) days after deposit in the
United States mail, postage prepaid, addressed to you at the last address you
provided to the Company.

                                        5

<PAGE>   6

        15. MISCELLANEOUS.

            (a) SUCCESSORS AND ASSIGNS. This Agreement shall inure to the
benefit of the successors and assigns of the Company and, subject to the
restrictions on transfer herein set forth, be binding upon you, your successors,
and assigns. The Purchase Option of the Company hereunder shall be assignable by
the Company at any time or from time to time, in whole or in part. Your rights
and obligations under this Agreement may only be assigned with the prior written
consent of the Company.

           (b) ATTORNEYS' FEES; SPECIFIC PERFORMANCE. You shall reimburse the
Company for all costs incurred by the Company in enforcing the performance of,
or protecting its rights under, any part of this Agreement, including reasonable
costs of investigation and attorneys' fees. It is the intention of the parties
that the Company, upon exercise of the Purchase Option and payment of the
purchase price for any Unvested Shares purchased upon exercise of the Purchase
Option, pursuant to the terms of this Agreement, shall be entitled to receive
the Stock, in specie, in order to have such Stock available for future issuance
without dilution of the holdings of other stockholders. Furthermore, it is
expressly agreed between the parties that money damages are inadequate to
compensate the Company for the Stock and that the Company shall, upon proper
exercise of the Purchase Option, be entitled to specific enforcement of its
rights to purchase and receive said Stock.

           (c) GOVERNING LAW; VENUE. This Agreement shall be governed by and
construed in accordance with the laws of the State of California as they apply
to agreements entered into in the State of California between residents of that
state. The parties agree that any action brought by either party to interpret or
enforce any provision of this Agreement shall be brought in, and each party
agrees to, and does hereby, submit to the jurisdiction and venue of, the
appropriate state or federal court located in San Diego, California.

           (d) FURTHER EXECUTION. The parties agree to take all such further
action(s) as may reasonably be necessary to carry out and consummate this
Agreement as soon as practicable, and to take whatever steps may be necessary to
obtain any governmental approval in connection with or otherwise qualify the
issuance of the securities that are the subject of this Agreement.

           (e) ENTIRE AGREEMENT; AMENDMENT. This Agreement constitutes the
entire agreement between the parties with respect to the subject matter hereof
and supersedes and merges all prior agreements or understandings, whether
written or oral. This Agreement may not be amended, modified or revoked, in
whole or in part, except by an agreement in writing signed by each of the
parties hereto.

           (f) SEVERABILITY. If one or more provisions of this Agreement are
held to be unenforceable under applicable law, the parties agree to renegotiate
such provision in good faith. In the event that the parties cannot reach a
mutually agreeable and enforceable replacement for such provision, then (i) such
provision shall be excluded from this Agreement, (ii) the balance of the
Agreement shall be interpreted as if such provision were so excluded and (iii)
the balance of the Agreement shall be enforceable in accordance with its terms.

                                        6

<PAGE>   7

           (g) COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which
together shall constitute one instrument.

        IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year first above written.

                                   EPIMMUNE INC.

                                   By: /s/ Robert De Vaere
                                       ----------------------------------------

                                   Title: VP, Finance & CFO
                                          -------------------------------------

                                   Address:  5820 Nancy Ridge Drive, Suite 100
                                             San Diego, CA 92121

                                   /s/ Emile Loria
                                   --------------------------------------------
                                   EMILE LORIA

                                   Address: 31 rue de Dr. Jean Arlaud
                                            31500 Toulouse, France

                                        7

<PAGE>   8

                                    EXHIBIT A

                               CERTAIN DEFINITIONS

For purposes of the Agreement (including this Exhibit A):

"AFFILIATE" means any parent corporation or subsidiary corporation of the
Company, whether now or hereafter existing, as those terms are defined in
Sections 424(e) and (f), respectively, of the Code.

"CAUSE" shall mean: (i) willful misconduct by you including, but not limited to,
dishonesty which materially and adversely reflects upon your ability to perform
your duties for the Company; (ii) your conviction of, or the entry of a pleading
of guilty or nolo contendere by you to, any crime involving moral turpitude or
any felony; (iii) fraud, embezzlement or theft against the Company; (iv) a
material breach by you of any material provision of the Proprietary Information
and Inventions Agreement between you and the Company; or (v) your willful and
habitual failure to attend to your duties as assigned by the Board of Directors
or officers of the Company to whom you report and, in the case of clauses (iv)
and (v) above, which breach, misconduct or non-performance is not cured by you
within thirty (30) days after you receive written notice from the Company of
such breach, misconduct or non-performance.

"CHANGE IN CONTROL" shall mean: (i) a dissolution or liquidation of the Company;
(ii) a sale or other disposition of all or substantially all of the assets of
the Company; (iii) a merger or consolidation in which the Company is not the
surviving corporation and in which beneficial ownership of securities of the
Company representing at least fifty percent (50%) of the combined voting power
entitled to vote in the election of Directors has changed; (iv) an acquisition
by any person, entity or group within the meaning of Section 13(d) or 14(d) of
the Exchange Act, or any comparable successor provisions (excluding any employee
benefit plan, or related trust, sponsored or maintained by the Company or
subsidiary of the Company or other entity controlled by the Company) of the
beneficial ownership (within the meaning of Rule 13d-3 promulgated under the
Exchange Act, or comparable successor rule) of securities of the Company
representing at least fifty percent (50%) of the combined voting power entitled
to vote in the election of Directors.

"CONTINUOUS SERVICE" means that the Participant's service with the Company or an
Affiliate, whether as an Employee or Director, is not interrupted or terminated.
The Participant's Continuous Service shall not be deemed to have terminated
merely because of a change in the capacity in which the Participant renders
service to the Company or an Affiliate as an Employee, or Director or a change
in the entity for which the Participant renders such service, provided that
there is no interruption or termination of the Participant's Continuous Service.
For example, a change in status from an Employee of the Company to a Director
will not constitute an interruption of Continuous Service. The Company's Board
of Directors or the chief executive officer of the Company, in that party's sole
discretion, may determine whether Continuous Service shall be considered
interrupted in the case of any leave of absence approved by that party,
including sick leave, military leave or any other personal leave.

<PAGE>   9

"DIRECTOR" means a member of the Board of Directors of the Company.

"EMPLOYEE" means any person employed by the Company or an Affiliate. Mere
service as a Director or payment of a director's fee by the Company or an
Affiliate shall not be sufficient to constitute "employment" by the Company or
an Affiliate.

"EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

"GOOD REASON" shall mean termination by you of your employment with the Company
upon not less than thirty (30) days' prior written notice to the Company (to
allow the Company to remedy any basis for Good Reason termination) as a result
of (i) a substantial diminution in the scope of your duties and authority within
the Company which results in the assignment of duties and responsibilities of
materially lesser status, dignity and character than your duties and
responsibilities on the date of execution of this Agreement, which is not the
result of your failure to attend to and/or successfully complete your duties and
responsibilities, (ii) any reduction in your base salary as initially set forth
herein or as may be increased from time to time, or (iii) relocation of your
office, without your consent, to a location that is more than thirty (30) miles
from the Company's current corporate headquarters.

"OFFICER" means a person who is an officer of the Company within the meaning of
Section 16 of the Exchange Act and the rules and regulations promulgated
thereunder.

"SECURITIES ACT" means the Securities Act of 1933, as amended.

                                       2
<PAGE>   10

                                    EXHIBIT B

                      ASSIGNMENT SEPARATE FROM CERTIFICATE

        FOR VALUE RECEIVED and pursuant to that certain Restricted Stock
Purchase Agreement (the "Agreement"), Emile Loria hereby sells, assigns and
transfers unto Epimmune Inc., a Delaware corporation ("Assignee"),
________________________ (__________) shares of the Common Stock of the
Assignee, standing in the undersigned's name on the books of said corporation
represented by Certificate No. _____ herewith and do hereby irrevocably
constitute and appoint ____________________________ as attorney-in-fact to
transfer the said stock on the books of the within named company with full power
of substitution in the premises. This Assignment may be used only in accordance
with and subject to the terms and conditions of the Agreement, in connection
with the reacquisition of shares of Common Stock of said corporation issued to
the undersigned pursuant to the Agreement, and only to the extent that such
shares remain subject to the Assignee's Purchase Option under the Agreement.

Dated:   January 16, 2001
      ------------------------------

                                      Signature:      /s/ Emile Loria
                                                 ------------------------------
                                                          EMILE LORIA

<PAGE>   11

                      ASSIGNMENT SEPARATE FROM CERTIFICATE

        FOR VALUE RECEIVED and pursuant to that certain Restricted Stock
Purchase Agreement (the "Agreement"), Emile Loria hereby sells, assigns and
transfers unto Epimmune Inc., a Delaware corporation ("Assignee"),
________________________ (__________) shares of the Common Stock of the
Assignee, standing in the undersigned's name on the books of said corporation
represented by Certificate No. _____ herewith and do hereby irrevocably
constitute and appoint ____________________________ as attorney-in-fact to
transfer the said stock on the books of the within named company with full power
of substitution in the premises. This Assignment may be used only in accordance
with and subject to the terms and conditions of the Agreement, in connection
with the reacquisition of shares of Common Stock of said corporation issued to
the undersigned pursuant to the Agreement, and only to the extent that such
shares remain subject to the Assignee's Purchase Option under the Agreement.

Dated:     January 16, 2001
       ------------------------

                                        Signature:  /s/ Emile Loria
                                                   ----------------------------
                                                   EMILE LORIA, RECIPIENT

<PAGE>   12

                                    EXHIBIT C

                            JOINT ESCROW INSTRUCTIONS

January 16, 2000

Assistant Secretary
Epimmune Inc.
5820 Nancy Ridge Drive
San Diego, CA  92121

Dear Sir/Madam:

        As Escrow Agent for both Epimmune Inc., a Delaware corporation (the
"Company"), and the undersigned recipient of stock of the Company ("Recipient"),
you are hereby authorized and directed to hold the documents delivered to you
pursuant to the terms of that certain Restricted Stock Purchase Agreement, dated
January 16, 2001 (the "Agreement") to which a copy of these Joint Escrow
Instructions is attached, in accordance with the following instructions set
forth below. Capitalized terms used but not otherwise defined herein shall have
the meaning given such terms in the Agreement.

        1. In the event Recipient ceases to render Continuous Service to the
Company or an Affiliate during the vesting period set forth in the Agreement,
the Company or its assignee will give to Recipient and you a written notice
specifying that the shares of Stock shall be transferred to the Company.
Recipient and the Company hereby irrevocably authorize and direct you to close
the transaction contemplated by such notice in accordance with the terms of said
notice.

        2. At the closing you are directed (a) to date any stock assignments
necessary for the transfer in question, (b) to fill in the number of shares of
Stock being transferred, and (c) to deliver same, together with the certificate
evidencing the shares of stock to be transferred, to the Company.

        3. Recipient irrevocably authorizes the Company to deposit with you any
certificates evidencing shares of Stock to be held by you hereunder and any
additions and substitutions to said shares as specified in the Agreement.
Recipient does hereby irrevocably constitute and appoint you as Recipient's
attorney-in-fact and agent for the term of this escrow to execute with respect
to such securities and other property all documents of assignment and/or
transfer and all stock certificates necessary or appropriate to make all
securities negotiable and complete any transaction herein contemplated.

<PAGE>   13

        4. This escrow shall terminate upon the later of (a) payment in full
under the Promissory Note of even date herewith and (b) vesting of all of the
shares of Stock or the earlier repurchase of all of the Unvested Shares by the
Company (or waiver of the Purchase Option with regard to such Unvested Shares).

        5. If at the time of termination of this escrow you should have in your
possession any documents, securities, or other property belonging to Recipient,
you shall deliver all of same to any pledgee entitled thereto or, if none, to
Recipient and shall be discharged of all further obligations hereunder.

        6. Your duties hereunder may be altered, amended, modified or revoked
only by a writing signed by all of the parties hereto.

        7. You shall be obligated only for the performance of such duties as are
specifically set forth herein and may rely and shall be protected in relying or
refraining from acting on any instrument reasonably believed by you to be
genuine and to have been signed or presented by the proper party or parties or
their assignees. You shall not be personally liable for any act you may do or
omit to do hereunder as Escrow Agent or as attorney-in-fact for Recipient while
acting in good faith and any act done or omitted by you pursuant to the advice
of your own attorneys shall be conclusive evidence of such good faith.

        8. You are hereby expressly authorized to disregard any and all warnings
given by any of the parties hereto or by any other person or corporation,
excepting only orders or process of courts of law, and are hereby expressly
authorized to comply with and obey orders, judgments or decrees of any court. In
case you obey or comply with any such order, judgment or decree of any court,
you shall not be liable to any of the parties hereto or to any other person,
firm or corporation by reason of such compliance, notwithstanding any such
order, judgment or decree being subsequently reversed, modified, annulled, set
aside, vacated or found to have been entered without jurisdiction.

        9. You shall not be liable in any respect on account of the identity,
authority or rights of the parties executing or delivering or purporting to
execute or deliver the Agreement or any documents or papers deposited or called
for hereunder.

        10. You shall not be liable for the outlawing of any rights under any
statute of limitations with respect to these Joint Escrow Instructions or any
documents deposited with you.

        11. You shall be entitled to employ such legal counsel, including but
not limited to Cooley Godward LLP, and other experts as you may deem necessary
properly to advise you in connection with your obligations hereunder, may rely
upon the advice of such counsel, and may pay such counsel reasonable
compensation therefor.

        12. Your responsibilities as Escrow Agent hereunder shall terminate if
you shall cease to be Assistant Secretary of the Company or if you shall resign
by written notice to each party. In

<PAGE>   14

the event of any such termination, the Company may appoint any officer or
assistant officer of the Company as successor Escrow Agent and Recipient hereby
confirms the appointment of such successor or successors as his attorney-in-fact
and agent to the full extent of your appointment.

        13. If you reasonably require other or further instruments in connection
with these Joint Escrow Instructions or obligations in respect hereto, the
necessary parties hereto shall join in furnishing such instruments.

        14. It is understood and agreed that should any dispute arise with
respect to the delivery and/or ownership or right of possession of the
securities, you may (but are not obligated to) retain in your possession without
liability to anyone all or any part of said securities until such dispute shall
have been settled either by mutual written agreement of the parties concerned or
by a final order, decree or judgment of a court of competent jurisdiction after
the time for appeal has expired and no appeal has been perfected, but you shall
be under no duty whatsoever to institute or defend any such proceedings.

        15. Any notice required or permitted hereunder shall be given in writing
and shall be deemed effectively given upon personal delivery or upon deposit in
any United States Post Box, by registered or certified mail with postage and
fees prepaid, addressed to each of the other parties hereunto entitled at the
following addresses, or at such other addresses as a party may designate by ten
(10) days' written notice to each of the other parties hereto:

        COMPANY:                 Epimmune Inc.
                                 5820 Nancy Ridge Drive
                                 San Diego, CA  92121
                                 Attn: Chief Financial Officer

        RECIPIENT:               Emile Loria
                                 31 rue du Dr Jean Arlaud
                                 31500 Toulouse, France

        ESCROW AGENT:            Epimmune Inc.
                                 5820 Nancy Ridge Drive
                                 San Diego, CA  92121
                                 Attn:  Assistant Secretary

        16. By signing these Joint Escrow Instructions you become a party hereto
only for the purpose of said Joint Escrow Instructions; you do not become a
party to the Agreement.

        17. This instrument shall be binding upon and inure to the benefit of
the parties hereto, and their respective successors and permitted assigns. It is
understood and agreed that references to "you" or "your" herein refer to the
original Escrow Agent and to any and all successor Escrow Agents. It is
understood and agreed that the Company may at any time or from

<PAGE>   15

time to time assign its rights under the Agreement and these Joint Escrow
Instructions in whole or in part.

                                            Very truly yours,

                                            EPIMMUNE, INC.

                                            By:   /s/ Robert De Vaere
                                               --------------------------------
                                            Title:   VP, Finance & CFO
                                                   ----------------------------

                                            RECIPIENT

                                                     /s/ Emile Loria
                                            -----------------------------------
                                            Emile Loria

ESCROW AGENT:

/s/ Robert De Vaere
-----------------------------------
Robert De Vaere

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