Document:

Secured Promissory Note Dated December 1, 2005

 SECURED PROMISSORY NOTE 
  
 $3,739,591.00 Dated: December 1, 2005 
  

FOR VALUE RECEIVED, Biovest International, Inc., a Delaware corporation (“Borrower”) promises to pay to the order of Accentia Biopharmaceuticals,
Inc., a Florida corporation (“Lender”), the principal sum of Three Million Seven Hundred Thirty-nine Thousand Five Hundred Ninety-one Dollars ($3,739,591.00). This Secured Promissory Note is created on account of the issuance by Lender
of 493,842 shares of Lender’s Common Stock to creditors of Borrower to pay and satisfy certain indebtedness of Borrower. 
  
 INTEREST: The unpaid principal shall bear simple interest at the rate equal to the Prime Rate as published on the last day of each month in the Wall Street
Journal. No payment of interest shall be due until maturity. 
  
 MATURITY:
The entire principal balance of this Note shall be due and payable in full within thirty (30) days of written demand for payment by Lender, delivered to Borrower via electronic mail, overnight express mail, or via hand delivery. There shall
be no penalty for early repayment of all or any part of the principal. 
  
 SECURITY: This Note shall be secured by the continued application of a General Security Agreement (“Security Agreement”) in favor of Lender upon all assets of Borrower, previously executed by the parties. Borrower agrees
that the UCC-1 filing in connection with this Security Agreement shall be maintained as current until the retirement of all indebtedness due from Borrower to Lender. 
  
 DEFAULT: The Borrower shall be in Default of this Note on the occurrence of any of the following events: (i) the Borrower shall
fail to meet its obligation to make the required principal or interest payments hereunder; (ii) the Borrower shall be dissolved or liquidated; (iii) the Borrower shall make an assignment for the benefit of creditors or shall be unable to,
or shall admit in writing their inability to pay their debts as they become due; (iv) the Borrower shall commence any case, proceeding, or other action under any existing or future law of any jurisdiction relating to bankruptcy, insolvency,
reorganization or relief of debtors, or any such action shall be commenced against the undersigned; (v) the Borrower shall suffer a receiver to be appointed for it or for any of its property or shall suffer a garnishment, attachment, levy or
execution; (vi) the Borrower shall sell, transfer, assign or otherwise dispose of any assets which are included in the Collateral securing this Note other than in the ordinary course of business. 
  
 REMEDIES: Upon default of this Note, Lender may declare the entire amount due and
owing hereunder to be immediately due and payable. Lender may also use all remedies in law and in equity to enforce and collect the amount owed under this Note. 
  

MISCELLANEOUS: Notwithstanding any provision herein or in any documents or instrument now or hereafter securing this Note, the total liability for payments in
the nature of interest shall not exceed the limits now or at any time in the future imposed by the applicable laws of the State of Delaware. 
  
 This Note shall be governed by, and construed in accordance with, the laws of the State of Delaware, notwithstanding the application of choice of law principles. Borrower
hereby waives demand, presentment, notice of dishonor, diligence in collecting, grace and notice of protest. 
  

			
	 BORROWER:
 BIOVEST INTERNATIONAL, INC.

		
	 By:   
	 	 
		
	 Name:
	 	 
		
	 Title:Promissory Note dated December 31, 2005.

 SECURED PROMISSORY NOTE 
  
 $2,433,222.07 Dated: December 31, 2005 
  

FOR VALUE RECEIVED, Biovest International, Inc., a Delaware corporation (“Borrower”) promises to pay to the order of Accentia Biopharmaceuticals,
Inc., a Florida corporation (“Lender”), the principal sum of Two Million Four Hundred Thirty-three Thousand Two Hundred Twenty-two Dollars and Seven cents ($2,433,222.07). This Secured Promissory Note evidences a series of loans made
by Lender to Borrower. 
  
 INTEREST: The unpaid principal shall bear simple
interest at the rate equal to the Prime Rate as published on the last day of each month in the Wall Street Journal. No payment of interest shall be due until maturity. 
  
 MATURITY: The entire principal balance of this Note shall be due and payable in full within thirty (30) days of written demand
for payment by Lender, delivered to Borrower via electronic mail, overnight express mail, or via hand delivery. There shall be no penalty for early repayment of all or any part of the principal. 
  
 SECURITY: This Note shall be secured by the continued application of a General
Security Agreement (“Security Agreement”) in favor of Lender upon all assets of Borrower, previously executed by the parties. Borrower agrees that the UCC-1 filing in connection with this Security Agreement shall be maintained as current
until the retirement of all indebtedness due from Borrower to Lender. 
  
 DEFAULT: The Borrower shall be in Default of this Note on the occurrence of any of the following events: (i) the Borrower shall fail to meet its obligation to make the required principal or interest payments hereunder;
(ii) the Borrower shall be dissolved or liquidated; (iii) the Borrower shall make an assignment for the benefit of creditors or shall be unable to, or shall admit in writing their inability to pay their debts as they become due;
(iv) the Borrower shall commence any case, proceeding, or other action under any existing or future law of any jurisdiction relating to bankruptcy, insolvency, reorganization or relief of debtors, or any such action shall be commenced against
the undersigned; (v) the Borrower shall suffer a receiver to be appointed for it or for any of its property or shall suffer a garnishment, attachment, levy or execution; (vi) the Borrower shall sell, transfer, assign or otherwise dispose
of any assets which are included in the Collateral securing this Note other than in the ordinary course of business. 
  
 REMEDIES: Upon default of this Note, Lender may declare the entire amount due and owing hereunder to be immediately due and payable. Lender may also use all
remedies in law and in equity to enforce and collect the amount owed under this Note. 
  
 MISCELLANEOUS: Notwithstanding any provision herein or in any documents or instrument now or hereafter securing this Note, the total liability for payments in the nature of interest shall not exceed the limits now or at any time in
the future imposed by the applicable laws of the State of Delaware. 
  
 This Note
shall be governed by, and construed in accordance with, the laws of the State of Delaware, notwithstanding the application of choice of law principles. Borrower hereby waives demand, presentment, notice of dishonor, diligence in collecting, grace
and notice of protest. 
  

			
	 BORROWER:
 BIOVEST INTERNATIONAL,
INC.

		
	By:	 	 
		
	 Name:
	 	 
		
	 Title:Summary of Hudson Highland Group, Inc. 2006 Incentive Compensation Program.

 EXHIBIT 10.1 
  
 Summary of Hudson Highland Group, Inc. 2006 Incentive Compensation Program 
  
 The following is a summary of the material terms of the Hudson Highland Group, Inc. (the
“Company”) 2006 Incentive Compensation Program: 
  

	•	 	The Compensation Committee of the Board of Directors of the Company annually sets bonus performance targets to reflect the growth in the Company’s earnings before income tax,
(“EBIT”) year over year. This growth is measured in both dollars of EBIT and EBIT as a percentage of revenue. EBIT is calculated net of bonuses payable under the program. 

  

	•	 	The target bonus payable to the Company’s Chief Executive Officer will be paid upon the achievement of EBIT performance targets. Bonus for achievement in excess of the targets
will be paid equal to 5% of EBIT earned above the target. 

  

	•	 	The bonuses payable to the Company’s business unit heads will be paid upon the achievement of EBIT performance targets for their respective business areas (80%) and the
Company (20%). Bonuses for achievement in excess of the target will be paid equal to 2% of their respective business unit’s EBIT. There will not be a cap on the amount of the bonuses payable to the heads of the Company’s business units or
to the Chief Executive Officer. 

  

	•	 	The bonuses payable to the executive officers of the Company (other than the Chief Executive Officer) will be paid based on the achievement of EBIT performance targets for the
Company. The bonus payable to individual executive officers of the Company (other than the Chief Executive Officer) will be capped at 200% of such executive officer’s respective base salary. 

  

	•	 	50% of the targeted bonus for each participant will be paid if threshold levels of the EBIT performance targets are achieved.Third Amendment to Credit Agreement dated as of January 26, 2006

 EXHIBIT 4.1 
  

SYBRON DENTAL SPECIALTIES, INC. 
  
 THIRD AMENDMENT 
 TO CREDIT AGREEMENT

  
 This THIRD AMENDMENT TO CREDIT
AGREEMENT (this “Amendment”) is dated as of January 26, 2006, and entered into by and among SYBRON DENTAL SPECIALTIES, INC., a Delaware corporation (successor by merger to Sybron Dental
Management, Inc., a Delaware corporation, the “Company”), KERR CORPORATION, a Delaware corporation (“Kerr”), ORMCO CORPORATION, a Delaware corporation (“Ormco”), and PINNACLE PRODUCTS,
INC., a Wisconsin corporation (“Pinnacle”; each of Company, Kerr, Ormco and Pinnacle are individually referred to herein as a “Domestic Borrower” and collectively, on a joint and several basis, as the
“Domestic Borrowers”), HAWE NEOS HOLDING SA, a corporation organized under the laws of Switzerland (“Offshore Borrower”; Offshore Borrower and each of the Domestic Borrowers are each individually referred to
herein as a “Borrower” and collectively as the “Borrowers”), the financial institutions listed on the signature pages hereof, CREDIT SUISSE, CAYMAN ISLANDS BRANCH (formerly known as Credit
Suisse First Boston, acting through its Cayman Islands Branch), as administrative agent for Lenders (in such capacity, “Administrative Agent”), and, for purposes of Section 4 hereof, the GUARANTORS LISTED ON THE
SIGNATURE PAGES HEREOF, and is made with reference to that certain Credit Agreement dated as of June 6, 2002, by and among Domestic Borrowers, Offshore Borrower, Lenders, LaSalle Bank National Association, as syndication agent, Bank of
Tokyo-Mitsubishi, Ltd., Chicago Branch, Fleet National Bank and Credit Lyonnais, New York Branch, as co-documentation agents, and Administrative Agent, as amended by that certain First Amendment to Credit Agreement, dated as of December 10,
2002, and that certain Second Amendment to Credit Agreement, dated as of July 14, 2004, in each case by and among Domestic Borrowers, Offshore Borrower, Lenders and Administrative Agent (as so amended, the “Credit Agreement”).
Capitalized terms used herein without definition shall have the same meanings herein as set forth in the Credit Agreement. 
  
 RECITALS 
  
 WHEREAS, the parties hereto desire to amend the Credit Agreement in accordance with the terms and conditions set forth herein; 
  
 NOW, THEREFORE, in consideration of the representations, warranties,
covenants and agreements herein contained, the parties hereto agree as follows: 
  
 Section 1. AMENDMENTS TO THE CREDIT AGREEMENT 
  
 1.1 Amendment to Section 1: Definitions. 
  
 The definition of “Cash Equivalents” contained in subsection 1.1 of the Credit Agreement is hereby
amended by deleting it in its entirety and substituting therefor the following: 

 ““Cash Equivalents” means, as at any date of determination,
(i) marketable securities (a) issued or directly and unconditionally guaranteed as to interest and principal by the United States Government or (b) issued by any agency of the United States the obligations of which are backed by the
full faith and credit of the United States, in each case maturing within one year after such date; (ii) marketable direct obligations issued by any state of the United States of America or any political subdivision of any such state or any
public instrumentality thereof, in each case maturing within one year after such date and having, at the time of the acquisition thereof, at least the third highest rating obtainable (i.e., “A” or better) from either Standard &
Poor’s (“S&P”) or Moody’s Investors Service, Inc. (“Moody’s”); (iii) commercial paper maturing no more than one year from the date of creation thereof and having, at the time of the
acquisition thereof, a rating of at least A-2 from S&P or at least P-2 from Moody’s; (iv) certificates of deposit, bankers’ acceptances or time deposits maturing within one year after such date and issued or accepted by or placed
with, and money market deposit accounts issued or offered by, any Lender or by any commercial bank organized under the laws of the United States of America or any state thereof or the District of Columbia that (a) is at least “adequately
capitalized” (as defined in the regulations of its primary Federal banking regulator) and (b) has Tier 1 capital (as defined in such regulations) of not less than $100,000,000; (v) shares of any money market mutual fund that has net
assets of not less than $500,000,000 and has at least the third highest rating obtainable from either S&P or Moody’s, including any such mutual fund managed or advised by any Lender or Administrative Agent; (vi) repurchase agreements
with a term of not more than one year entered into with a bank or trust company (including any of the Lenders) or recognized securities dealer having capital and surplus in excess of $500 million for direct obligations issued by or fully guaranteed
by the United States in which Company or its Subsidiary entering into such agreement shall have a perfected first priority security interest (subject to no other Liens) and having, on the date of purchase thereof, a fair market value of at least one
hundred percent (100%) of the amount of the repurchase obligations; and (vii) other short-term investments of Foreign Subsidiaries of a type comparable to the foregoing categories”. 
  
 1.2 Amendment to Section 7.3: Investments; Acquisitions. 
  
 Subsection 7.3(ii) of the Credit Agreement is hereby amended
by deleting it in its entirety and substituting therefor the following: 
  
 “(ii) So long as no Event of Default or Potential Event of Default has occurred and is continuing, the Foreign Subsidiaries may make investments in and own Cash Equivalents;”. 
  
 Section 2. REPRESENTATIONS AND WARRANTIES 
  
 In order to induce Administrative Agent and Lenders to enter into this
Amendment and to amend the Credit Agreement in the manner provided herein, each Borrower 
  

 2 

 jointly and severally represents and warrants to Administrative Agent and each Lender that the following statements are
true, correct and complete: 
  
 A. Corporate Power and
Authority. Each Borrower has all requisite corporate power and authority to enter into this Amendment and perform its obligations under the Credit Agreement as amended by this Amendment (the “Amended Agreement”). 
  
 B. Authorization of Agreements. The execution and delivery of this
Amendment and the performance of the Amended Agreement have been duly authorized by all necessary corporate action on the part of each Borrower. 
  
 C. No Conflict. The execution and delivery by each Borrower of this Amendment and the performance by each Borrower of the Amended Agreement do not
and will not (i) violate any provision of any law or any governmental rule or regulation applicable to the Company or any of its Subsidiaries, the Certificate or Articles of Incorporation or Bylaws of the Company or any of its Subsidiaries or
any order, judgment or decree of any court or other agency of government binding on the Company or any of its Subsidiaries, (ii) conflict with, result in a breach of or constitute (with due notice or lapse of time or both) a default under any
Contractual Obligation of the Company or any of its Subsidiaries, except for such conflicts, breaches or defaults which could not reasonably be expected to result in a Material Adverse Effect, (iii) result in or require the creation or
imposition of any Lien upon any of the properties or assets of the Company or any of its Subsidiaries, or (iv) require any approval of stockholders or any approval or consent of any Person under any Contractual Obligation of the Company or any
of its Subsidiaries. 
  
 D. Governmental Consents. The
execution and delivery by each Borrower of this Amendment and the performance by each Borrower of the Amended Agreement do not and will not require any Governmental Authorization. 
  
 E. Binding Obligation. This Amendment has been duly executed and delivered by each Borrower and this Amendment and
the Amended Agreement are the legally valid and binding obligations of each Borrower, enforceable against each Borrower in accordance with their respective terms, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or
similar laws relating to or limiting creditors’ rights generally or by equitable principles relating to enforceability. 
  
 F. Incorporation of Representations and Warranties From Credit Agreement. The representations and warranties contained in Section 5 of the
Credit Agreement are and will be true, correct and complete in all material respects on and as of the Third Amendment Effective Date to the same extent as though made on and as of that date, except to the extent that such representations and
warranties specifically relate to an earlier date, in which case they were true, correct and complete in all material respects on and as of such earlier date. 
  

G. Absence of Default. After giving effect to all amendments and waivers to the Credit Agreement entered into prior to this Amendment, no event
has occurred and is continuing or will result from the consummation of the transactions contemplated by this Amendment that would constitute an Event of Default or a Potential Event of Default. 
  

 3 

 Section 3. MISCELLANEOUS 
  
 A. Reference to and Effect on the Credit Agreement and the Other Loan Documents. 
  
 (i) On and after the Third Amendment Effective Date, each reference in the
Credit Agreement to “this Agreement”, “hereunder”, “hereof, “herein” or words of like import referring to the Credit Agreement, and each reference in the other Loan Documents to the “Credit Agreement”,
“thereunder”, “thereof” or words of like import referring to the Credit Agreement shall mean and be a reference to the Amended Agreement. 
  

(ii) Except as specifically amended by this Amendment, the Credit Agreement and the other Loan Documents shall remain in full force and effect and are
hereby ratified and confirmed. 
  
 (iii) The execution, delivery
and performance of this Amendment shall not, except as expressly provided herein, constitute a waiver of any provision of, or operate as a waiver of any right, power or remedy of Administrative Agent or any Lender under, the Credit Agreement or any
of the other Loan Documents. 
  
 B. Fees and Expenses. Each
Borrower acknowledges that all costs, fees and expenses of the type described in subsection 11.4 of the Credit Agreement that are incurred by Administrative Agent and its counsel with respect to this Amendment and the documents and transactions
contemplated hereby shall be for the account of the Borrowers. 
  
 C. Headings. Section and subsection headings in this Amendment are included herein for convenience of reference only and shall not constitute a part of this Amendment for any other purpose or be given any substantive effect.

  
 D. Applicable Law. THIS AMENDMENT AND THE RIGHTS AND
OBLIGATIONS OF THE PARTIES HEREUNDER SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK (INCLUDING, WITHOUT LIMITATION, SECTION 5-1401 OF THE GENERAL OBLIGATIONS LAW OF THE STATE
OF NEW YORK), WITHOUT REGARD TO CONFLICT OF LAWS PRINCIPLES THAT WOULD REQUIRE THE APPLICATION OF ANOTHER LAW. 
  
 E. Counterparts; Effectiveness. This Amendment may be executed in any number of counterparts and by different parties hereto in separate
counterparts, each of which when so executed and delivered shall be deemed an original, but all such counterparts together shall constitute but one and the same instrument; signature pages may be detached from multiple separate counterparts and
attached to a single counterpart so that all signature pages are physically attached to the same document. This Amendment shall become effective upon the first date (the “Third Amendment Effective Date”) on which each of the
following shall have occurred: (i) the execution of a counterpart hereof by Administrative Agent, each Borrower, each other Loan Party and Requisite Lenders, and (ii) receipt by Company and Administrative Agent of written (including,
without limitation, facsimile and electronic mail) or telephonic notification of such execution. 
  

 4 

 Section 4. ACKNOWLEDGEMENT AND CONSENT BY GUARANTORS 
  
 Each guarantor listed on the signature pages hereof (each, a
“Guarantor” and, collectively, the “Guarantors”) hereby acknowledges that it has read this Amendment and consents to the terms of this Amendment, and hereby confirms and agrees that, notwithstanding the
effectiveness of this Amendment, the obligations of each Guarantor under its applicable Guaranty shall not be impaired or affected and the applicable Guaranty is, and shall continue to be, in full force and effect and is hereby confirmed and
ratified in all respects. Each Guarantor further agrees that nothing in the Credit Agreement, this Amendment or any other Loan Document shall be deemed to require the consent of such Guarantor to any future amendment to the Credit Agreement.

  
 *    *    *    *    * 
  

 5 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and
delivered by their respective officers thereunto duly authorized as of the date first written above. 
  

					
	COMPANY:	 	SYBRON DENTAL SPECIALTIES, INC.
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Vice President, Secretary and General Counsel

		
	OTHER DOMESTIC BORROWERS:	 	KERR CORPORATION
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	 	 	ORMCO CORPORATION
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	 	 	PINNACLE PRODUCTS, INC.
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	OFFSHORE BORROWER:	 	HAWE NEOS HOLDING SA
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

					
	GUARANTORS:	 	ALLESEE ORTHODONTIC APPLIANCES, INC.
		
	 	 	METREX RESEARCH CORPORATION
		
	 	 	SYBRON CANADA HOLDINGS, INC.
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	 	 	KERRHAWE SA
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	 	 	SYBRON CANADA LIMITED PARTNER COMPANY
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

		
	 	 	SYBRON CANADA LIMITED
			
	 	 	 By:
	 	 /s/ Stephen J. Tomassi

	 	 	 Name:
	 	 Stephen J. Tomassi

	 	 	 Title:
	 	 Authorized Representative

					
	LENDERS:	 	 CREDIT SUISSE, CAYMAN ISLANDS BRANCH (formerly known as Credit Suisse First Boston, acting through its Cayman Islands
Branch),
 as Administrative Agent and Lender

			
	 	 	 By:
	 	 /s/ Phillip Ho

	 	 	 Name:
	 	 Phillip Ho

	 	 	 Title:
	 	 Director

		
	 	 	 and

			
	 	 	 By:
	 	 /s/ Karim Blasetti

	 	 	 Name:
	 	 Karim Blasetti

	 	 	 Title:
	 	 Associate

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