Document:

PROMISSORY
                                      NOTE

FACE AMOUNT                                                  $1,560,000
PRICE                                                        $1,300,000
INTEREST RATE                                                0% per month
NOTE NUMBER                                                  June-2005-101
ISSUANCE DATE                                                June 30, 2005
MATURITY DATE                                                January 30, 2006

      FOR VALUE RECEIVED, DNAPrint Genomics, Inc., a Utah corporation (the
"Company"), (OTC BB: DNAP) hereby promises to pay to the order of DUTCHESS
PRIVATE EQUITIES FUND, II, L.P. (the "Holder") by the Maturity Date, or earlier,
the Amount of One Million Five Hundred and Sixty Thousand Dollars ($1,560,000)
U.S., in such amounts, at such times and on such terms and conditions as are
specified herein (this "Note").

      Any capitalized term not defined in this Note are defined in the
Investment Agreement for the Equity Line of Credit between Dutchess Private
Equities Fund II, LP (the "Investor") and the Company (the "Equity Line").

            Until the Company files an additional registration statement with
the United States Securities and Exchange Commission ("SEC") for the resale of
additional shares ("Additional Registration Statement") for the Equity Line and
that Registration Statement is declared effective by the SEC ("Effective Date"),
the Company will hold all funds raised by the Equity Line in escrow held at Bank
of America with the name DNA print- Dutchess Trustee Account ("Trustee Account")

            During such time as funds are being held in escrow at the Trustee
Account, the Company acknowledges and gives approval for Investor to repay the
Holder the amounts due at the Closing of each Put. Upon the Effective Date, the
Holder shall release the funds in escrow to the Company, provided the Company is
in good standing and not default of this Note.

Article 1 Method of Payment

            Payments made by the Company in satisfaction of this Note (each a
"Payment," and collectively, the "Payments") shall be made from each Put from
the Equity Line of Credit with the Investor given by the Company to the
Investor. The Company shall make payments to the Holder in the amount of the
greater of a) fifty percent (50%) of each Put to the Investor from the Company;
or, b) one hundred and fifty thousand dollars ($150,000) (the "Payment Amount")
until the Face Amount is paid in full, minus any fees due. First payment will be
due at the successful Closing of the next Put ("Payment Date" or "Payment
Dates") and all subsequent Payments will be made at the Closing of every Put to
the Investor thereafter until this Note is paid in full. Notwithstanding any
provision to the contrary in this Note, the Company may pay in full to the
Holder the Face Amount, or any balance remaining thereof, in readily available
funds at any time and from time to time without penalty.

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      Section 1.1 Payment Increase

            The Holder shall have the option to increase the Payments due from
each Put based on the aggregate amount of funds raised by the Company. Upon the
Company receiving an aggregate amount of an additional one million dollars
($1,000,000) in financing from the Holder, any other financial institution or
person, the sole exception being any funds received under the current financing
agreement with La Jolla Cove Capital ("La Jolla"), the Company shall increase
the Payment Amount based on the following schedule:

      Total Additional Aggregate Dollars       Payment Amount
      Raised:                                  (as a percentage of a Put)
      ----------------------------------       --------------------------
      Up to $1,000,000                         50%
      Over $1,000,000 to $1,500,000            75%
      Over $1,500,000 to $2,000,000            80%
      Over $2,000,000                          100%

      Payments pursuant to this Note shall be made directly from the Closing of
each Put ("Put Closing") and shall be wired directly to the Holder on the
Closing Date and shall be included in the Total Aggregate Dollars Raised. The
Holder shall retain the sole right and from time to time may elect to lower the
amount of a payment ("Lowered Payment Amount") if so requested by the Company.
In the event of a Lowered Payment Amount, the next payment under this Note will
be increased by the greater of 1) the percentage difference between the next
Payment and the Lowered Payment Amount (Example: If the Company places a Put for
$100,000 ($50,000 of which would go toward payment of the Face Amount of this
Note) and the Company requests a Lowered Payment such that $30,000 will go
toward payment of the Face Amount of this Note (thus, the Company owes Holder
$20,000, which is 40% of the total amount owed to the Holder under such Put),
and the next Put is for $500,000 ($250,000 of which will go toward payment of
the Face Amount of this Note), then the total amount owed to the Holder under
this Put will be $250,000 multiplied by 1.40) or 2) the actual dollar amount
difference between the next payment and the Lowered Payment Amount.

      The Company hereby authorizes Dutchess Private Equities Fund, II LP, to
transfer funds directly to the Holder from each Put in connection with the
Company's execution of the Collateral (as defined below). The Puts shall be
deemed closed for the amounts transferred to the Holder immediately upon the Put
Closing.

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Article 2 Collateral

      The Company does hereby agree to issue twenty (20) Put Notices
("Collateral") to the Investor for the full amount applicable under the terms of
the Equity Line Investment Agreement ("Investment Agreement") and shall do so at
the maximum frequency allowed under the Investment Agreement, until such time as
the Note is paid in full. The Company shall deliver the Collateral upon
execution of this Note (hereto attached as Exhibit A). Upon the completion of
the Company's obligation to the Holder of the Face Amount of this Note, the
Company will not be under further obligation to complete any more Puts. All
remaining Put sheets shall be marked "VOID" by the Investor and sent back to the
Company at the Company's request.

Article 3 Unpaid Amounts

      In the event that on the Maturity Date the Company has any remaining
amounts unpaid on this Note (the "Residual Amount"), the Holder can exercise its
right to increase the Residual Amount by ten percent (10%) as an initial penalty
and two and one-half percent (2.5%) per month paid as liquated damages
("Liquidated Damages"). The Liquated Damages will be compounded daily. If the
aforementioned occurs, the Company will be in Default and the remedies as
described in Article 4 may be taken at the Holder's discretion. It is the
intention and acknowledgement of both parties that the Liquidated Damages not be
deemed as interest.

Article 4 Defaults and Remedies

      Section 4.1 Events of Default. An "Event of Default" or "Default" occurs
if (a) the Company does not make the Payment of the Face Amount of this Note
within two (2) business days of the applicable Closing of a Put, a Payment Date;
or, a balance on the Note exists on the Maturity Date, as applicable, upon
redemption or otherwise, (b) the Company, pursuant to or within the meaning of
any Bankruptcy Law (as hereinafter defined): (i) commences a voluntary case;
(ii) consents to the entry of an order for relief against it in an involuntary
case; (iii) consents to the appointment of a Custodian (as hereinafter defined)
of it or for all or substantially all of its property; (iv) makes a general
assignment for the benefit of its creditors; or (v) a court of competent
jurisdiction enters an order or decree under any Bankruptcy Law that: (A) is for
relief against the Company in an involuntary case; (B) appoints a Custodian of
the Company or for all or substantially all of its property; or (C) orders the
liquidation of the Company, and the order or decree remains unstayed and in
effect for sixty (60) calendar days; (c) the Company's $0.01 par value common
stock (the "Common Stock") is suspended or is no longer listed on any recognized
exchange, including an electronic over-the-counter bulletin board, for in excess
of two (2) consecutive trading days; or (d) either the registration statement
for the underlying shares in the Investment Agreement or the Additional
Registration Statement does not remain effective for any reason or (e) the
Company fails to comply with any of the Articles of this Agreement as outlined.
As used in this Section 4.1, the term "Bankruptcy Law" means Title 11 of the
United States Code or any similar federal or state law for the relief of
debtors. The term "Custodian" means any receiver, trustee, assignee, liquidator
or similar official under any Bankruptcy Law. (f) The Company fails to file the
Additional Registration Statement with the SEC by July 12, 2005, 5:30 pm Eastern
Daylight Time.

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      In the Event of Default, the Holder may elect to secure a portion of the
Company's assets not to exceed 200% of the Face Amount of the Note, including,
but not limited to: accounts receivable, cash, marketable securities, equipment,
building, land or inventory. The Holder may also elect to garnishee Revenue from
the Company in an amount that will repay the Holder on the schedules outlined in
this Agreement.

      For each Event of Default, as outlined in this Agreement, the Holder can
exercise its right to increase the Residual Amount of the Debenture by ten
percent (10%) as an initial penalty. In addition, the Holder may elect to
increase the Residual Amount by two and one-half percent (2.5%) per month paid
as a penalty for Liquidated Damages. The Liquated Damages will be compounded
daily. It is the intention and acknowledgement of both parties that the
Liquidated Damages not be deemed as interest.

      In the event of a Default hereunder, the Holder shall have the right, but
not the obligation, to 1) switch the Residual Amount to a three-year
("Convertible Maturity Date"), fifteen percent (15%) interest bearing
convertible debenture at the terms described in Section 4.2 (the "Convertible
Debenture"). At such time of Default, the Convertible Debenture shall be
considered closed ("Convertible Closing Date"). If the Holder chooses to convert
the Residual Amount to a Convertible Debenture, the Company shall have twenty
(20) business days after notice of the same (the "Notice of Convertible
Debenture") to file a registration statement covering an amount of shares equal
to three hundred percent (300%) of the Residual Amount. Such registration
statement shall be declared effective under the Securities Act of 1933, as
amended (the "Securities Act"), by the Securities and Exchange Commission (the
"Commission") within forty (40) business days of the date the Company files such
Registration Statement. In the event the Company does not file such registration
statement within twenty (20) business days of the Holder's request, or such
registration statement is not declared by the Commission to be effective under
the Securities Act within the time period described above , the Residual Amount
shall increase by one thousand dollars ($1,000) per day. In the event the
Company is given the option for accelerated effectiveness of the registration
statement, it agrees that it shall cause such registration statement to be
declared effective as soon as reasonably practicable. In the event that the
Company is given the option for accelerated effectiveness of the registration
statement, but chooses not to cause such registration statement to be declared
effective on such accelerated basis, the Residual Amount shall increase by one
thousand dollars ($1,000) per day commencing on the earliest date as of which
such registration statement would have been declared to be effective if subject
to accelerated effectiveness; or 2) the Holder may increase the Payment Amount
described under Article 1 to fulfill the repayment of the Residual Amount. The
Company shall provide full cooperation to the Holder in directing funds owed to
the Holder on any Put to the Investor. The Company agrees to diligently carry
out the terms outlined in the Investment Agreement for delivery of any such
shares. In the event the Company is not diligently fulfilling its obligation to
direct funds owed to the Holder from Puts to the Investor, as reasonably
determined by the Holder, the Holder may, after giving the Company two (2)
business days' advance notice to cure the same, elect to increase the Residual
Amount of the Note by 2.5% each day, compounded daily.

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      Section 4.2 Conversion Privilege

            (a) The Holder shall have the right to convert the Convertible
Debenture into shares of Common Stock at any time following the Convertible
Closing Date and which is before the close of business on the Convertible
Maturity Date. The number of shares of Common Stock issuable upon the conversion
of the Convertible Debenture shall be determined pursuant to Section 4.3, but
the number of shares issuable shall be rounded up or down, as the case may be,
to the nearest whole share.

            (b) The Convertible Debenture may be converted, whether in whole or
in part, at any time and from time to time.

            (c) In the event all or any portion of the Convertible Debenture
remains outstanding on the Convertible Maturity Date (the "Debenture Residual
Amount"), the unconverted portion of such Convertible Debenture will
automatically be converted into shares of Common Stock on such date in the
manner set forth in Section 4.3.

      Section 4.3 Conversion Procedure.

      The Residual Amount may be converted, in whole or in part any time and
from time to time, following the Convertible Closing Date. Such conversion shall
be effectuated by surrendering to the Company, or its attorney, the Convertible
Debenture to be converted together with a facsimile or original of the signed
notice of conversion (the "Notice of Conversion"). The date on which the Notice
of Conversion is effective ("Conversion Date") shall be deemed to be the date on
which the Holder has delivered to the Company a facsimile or original of the
signed Notice of Conversion, as long as the original Convertible Debenture(s) to
be converted are received by the Company within five (5) business days
thereafter. At such time that the original Convertible Debenture has been
received by the Company, the Holder can elect to whether a reissuance of the
Convertible Debenture is warranted, or whether the Company can retain the
Convertible Debenture as to a continual conversion by the Holder.
Notwithstanding the above, any Notice of Conversion received by 4:00 P.M. EST
shall be deemed to have been received the following business day (receipt being
via a confirmation of the time such facsimile to the Company is received).

            (a) Common Stock to be Issued. Upon the conversion of any
Convertible Debentures and upon receipt by the Company or its attorney of a
facsimile or original of the Holder's signed Notice of Conversion, the Company
shall instruct its transfer agent to issue stock certificates without
restrictive legends or stop transfer instructions, if at that time the
aforementioned registration statement described in Section 4.1 has been declared
effective (or with proper restrictive legends if the registration statement has
not as yet been declared effective), in such denominations to be specified at
conversion representing the number of shares of Common Stock issuable upon such
conversion, as applicable. In the event that the Debenture is aged one year and
deemed sellable under Rule 144, the Company shall, upon a Notice of Conversion,
instruct the transfer agent to issue free trading certificates without
restrictive legends, subject to other applicable securities laws. The Company is
responsible to provide all costs associated with the issuance of the shares,
including but not limited to the opinion letter, FedEx of the certificates and
any other costs that arise. The Company shall act as registrar and shall
maintain an appropriate ledger containing the necessary information with respect
to each Convertible Debenture. The Company warrants that no instructions, other
than these instructions, have been given or will be given to the transfer agent
and that the Common Stock shall otherwise be freely resold, except as may be set
forth herein or subject to applicable law.

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            (b) Conversion Rate. Holder is entitled to convert the Debenture
Residual Amount, plus accrued interest, anytime following the Convertible
Maturity Date, at the lesser of (i) fifty percent (50%) of the lowest closing
bid price during the fifteen (15) trading immediately preceding the Convertible
Maturity Date or (ii) 100% of the lowest bid price for the twenty (20) trading
days immediately preceding the Convertible Maturity Date ("Fixed Conversion
Price"). No fractional shares or scrip representing fractions of shares will be
issued on conversion, but the number of shares issuable shall be rounded up or
down, as the case may be, to the nearest whole share.

            (c) Nothing contained in the Convertible Debenture shall be deemed
to establish or require the payment of interest to the Holder at a rate in
excess of the maximum rate permitted by governing law. In the event that the
rate of interest required to be paid exceeds the maximum rate permitted by
governing law, the rate of interest required to be paid thereunder shall be
automatically reduced to the maximum rate permitted under the governing law and
such excess shall be returned with reasonable promptness by the Holder to the
Company.

            (d) It shall be the Company's responsibility to take all necessary
actions and to bear all such costs to issue the Common Stock as provided herein,
including the responsibility and cost for delivery of an opinion letter to the
transfer agent, if so required. Holder shall be treated as a shareholder of
record on the date Common Stock is issued to the Holder. If the Holder shall
designate another person as the entity in the name of which the stock
certificates issuable upon conversion of the Convertible Debenture are to be
issued prior to the issuance of such certificates, the Holder shall provide to
the Company evidence that either no tax shall be due and payable as a result of
such transfer or that the applicable tax has been paid by the Holder or such
person. Upon surrender of any Convertible Debentures that are to be converted in
part, the Company shall issue to the Holder a new Convertible Debenture equal to
the unconverted amount, if so requested in writing by the Holder.

            (e) Within five (5) business days after receipt of the documentation
referred to above in Section 4.2, the Company shall deliver a certificate, for
the number of shares of Common Stock issuable upon the conversion. In the event
the Company does not make delivery of the Common Stock as instructed by Holder
within five (5) business days after the Conversion Date, then in such event the
Company shall pay to the Holder one percent (1%) in cash of the dollar value of
the Debenture Residual Amount remaining after said conversion, compounded daily,
per each day after the fifth (5th) business day following the Conversion Date
that the Common Stock is not delivered to the Purchaser.

            The Company acknowledges that its failure to deliver the Common
Stock within five (5) business days after the Conversion Date will cause the
Holder to suffer damages in an amount that will be difficult to ascertain.
Accordingly, the parties agree that it is appropriate to include in this Note a
provision for liquidated damages The parties acknowledge and agree that the
liquidated damages provision set forth in this section represents the parties'
good faith effort to quantify such damages and, as such, agree that the form and
amount of such liquidated damages are reasonable and will not constitute a
penalty. The payment of liquidated damages shall not relieve the Company from
its obligations to deliver the Common Stock pursuant to the terms of this
Convertible Debenture.

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            (f) The Company shall at all times reserve (or make alternative
written arrangements for reservation or contribution of shares) and have
available all Common Stock necessary to meet conversion of the Convertible
Debentures by the Holder of the entire amount of Convertible Debentures then
outstanding. If, at any time the Holder submits a Notice of Conversion and the
Company does not have sufficient authorized but unissued shares of Common Stock
(or alternative shares of Common Stock as may be contributed by stockholders of
the Company) available to effect, in full, a conversion of the Convertible
Debentures (a "Conversion Default," the date of such default being referred to
herein as the "Conversion Default Date"), the Company shall issue to the Holder
all of the shares of Common Stock which are available, and the Notice of
Conversion as to any Convertible Debentures requested to be converted but not
converted (the "Unconverted Convertible Debentures"), may be deemed null and
void upon written notice sent by the Holder to the Company. The Company shall
provide notice of such Conversion Default ("Notice of Conversion Default") to
the Holder, by facsimile within three (3) business days of such default (with
the original delivered by overnight mail or two day courier), and the Holder
shall give notice to the Company by facsimile within five (5) business days of
receipt of the original Notice of Conversion Default (with the original
delivered by overnight mail or two day courier) of its election to either
nullify or confirm the Notice of Conversion.

      The Company agrees to pay the Holder payments for a Conversion Default
("Conversion Default Payments") in the amount of (N/365) multiplied by .24
multiplied by the initial issuance price of the outstanding or tendered but not
converted Convertible Debentures held by the Holder where N = the number of days
from the Conversion Default Date to the date (the "Authorization Date") that the
Company authorizes a sufficient number of shares of Common Stock to effect
conversion of all remaining Convertible Debentures. The Company shall send
notice ("Authorization Notice") to the Holder that additional shares of Common
Stock have been authorized, the Authorization Date, and the amount of Holder's
accrued Conversion Default Payments. The accrued Conversion Default shall be
paid in cash or shall be convertible into Common Stock at the conversion rate
set forth in the first sentence of this paragraph, upon written notice sent by
the Holder to the Company, which Conversion Default shall be payable as follows:
(i) in the event the Holder elects to take such payment in cash, cash payments
shall be made to the Holder by the fifth (5th) day of the following calendar
month, or (ii) in the event Holder elects to take such payment in stock, the
Holder may convert such payment amount into Common Stock at the conversion rate
set forth in the first sentence of this paragraph at any time after the fifth
(5th) day of the calendar month following the month in which the Authorization
Notice was received, until the expiration of the mandatory three (3) year
conversion period.

      The Company acknowledges that its failure to maintain a sufficient number
of authorized but unissued shares of Common Stock to effect in full a conversion
of the Convertible Debentures will cause the Holder to suffer damages in an
amount that will be difficult to ascertain. Accordingly, the parties agree that
it is appropriate to include in this Agreement a provision for liquidated
damages. The parties acknowledge and agree that the liquidated damages provision
set forth in this section represents the parties' good faith effort to quantify
such damages and, as such, agree that the form and amount of such liquidated
damages are reasonable and will not constitute a penalty. The payment of
liquidated damages shall not relieve the Company from its obligations to deliver
the Common Stock pursuant to the terms of this Convertible Debenture.

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            (g) If, by the third (3rd) business day after the Conversion Date of
any portion of the Convertible Debentures to be converted (the "Delivery Date"),
the transfer agent fails for any reason to deliver the Common Stock upon
conversion by the Holder and after such Delivery Date, the Holder purchases, in
an open market transaction or otherwise, shares of Common Stock (the "Covering
Shares") solely in order to make delivery in satisfaction of a sale of Common
Stock by the Holder (the "Sold Shares"), which delivery such Holder anticipated
to make using the Common Stock issuable upon conversion (a "Buy-In"), the
Company shall pay to the Holder, in addition to any other amounts due to Holder
pursuant to this Convertible Debenture, and not in lieu thereof, the Buy-In
Adjustment Amount (as defined below). The "Buy In Adjustment Amount" is the
amount equal to the excess, if any, of (x) the Holder's total purchase price
(including brokerage commissions, if any) for the Covering Shares over (y) the
net proceeds (after brokerage commissions, if any) received by the Holder from
the sale of the Sold Shares. The Company shall pay the Buy-In Adjustment Amount
to the Holder in immediately available funds within five (5) business days of
written demand by the Holder. By way of illustration and not in limitation of
the foregoing, if the Holder purchases shares of Common Stock having a total
purchase price (including brokerage commissions) of $11,000 to cover a Buy-In
with respect to shares of Common Stock it sold for net proceeds of $10,000, the
Buy-In Adjustment Amount which the Company will be required to pay to the Holder
will be $1,000.

            (h) The Company shall defend, protect, indemnify and hold harmless
the Holder and all of its shareholders, officers, directors, employees, counsel,
and direct or indirect investors and any of the foregoing person's agents or
other representatives (including, without limitation, those retained in
connection with the transactions contemplated by this Agreement) (collectively,
the "Section 4.3(h) Indemnitees") from and against any and all actions, causes
of action, suits, claims, losses, costs, penalties, fees, liabilities and
damages, and expenses in connection therewith (irrespective of whether any such
Section 4.3(h) Indemnitee is a party to the action for which indemnification
hereunder is sought), and including reasonable attorneys' fees and disbursements
(the "Section 4.3(h) Indemnified Liabilities"), incurred by any Section 4.3(h)
Indemnitee as a result of, or arising out of, or relating to (i) any
misrepresentation or breach of any representation or warranty made by the
Company in the Transaction Documents or any other certificate, instrument or
document contemplated hereby or thereby, (ii) any breach of any covenant,
agreement, or obligation of the Company contained in the Transaction Documents
or any other certificate, instrument, or document contemplated hereby or
thereby, (iii) any cause of action, suit, or claim brought or made against such
Section 4.3(h) Indemnitee by a third party and arising out of or resulting from
the execution, delivery, performance, or enforcement of the Transaction
Documents or any other certificate, instrument, or document contemplated hereby
or thereby, (iv) any transaction financed or to be financed in whole or in part,
directly or indirectly, with the proceeds of the issuance of the Common Stock
underlying the Convertible Debenture ("Securities"), or (v) the status of the
Holder or holder of the Securities as an investor in the Company, except insofar
as any such misrepresentation, breach or any untrue statement, alleged untrue
statement, omission, or alleged omission is made in reliance upon and in
conformity with written information furnished to the Company by the Holder or
the Investor which is specifically intended by the Holder or the Investor to be
relied upon by the Company, including for use in the preparation of any such
registration statement, preliminary prospectus, or prospectus, or is based on
illegal trading of the Common Stock by the Holder or the Investor. To the extent
that the foregoing undertaking by the Company may be unenforceable for any
reason, the Company shall make the maximum contribution to the payment and
satisfaction of each of the Indemnified Liabilities that is permissible under
applicable law. The indemnity provisions contained herein shall be in addition
to any cause of action or similar rights the Holder may have, and any
liabilities the Holder may be subject to.

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Article 5 Additional Financing

            The Company will not enter into any additional financing agreements,
debt or equity, without prior expressed written consent from the Holder, which
shall not be unreasonably withheld. Failure to do so will result in an Event of
Default and the Holder may elect to take the action outlined in Article 4. The
sole exception shall be any funds received under the current financing agreement
with La Jolla.

Article 6 Notice.

      Any notices, consents, waivers or other communications required or
permitted to be given under the terms of this Note must be in writing and will
be deemed to have been delivered (i) upon receipt, when delivered personally;
(ii) upon receipt, when sent by facsimile (provided a confirmation of
transmission is mechanically or electronically generated and kept on file by the
sending party); or (iii) one (1) day after deposit with a nationally recognized
overnight delivery service, in each case properly addressed to the party to
receive the same. The addresses and facsimile numbers for such communications
shall be:

If to the Company:

      Attn: Richard Gabriel
      DNAPrint Genomics
      900 Cocoanut Avenue
      Sarasota, FL 34236
      Telephone: (941) 366-3400
      Fax: 210.249.4130

If to the Holder:

      Dutchess Private Equities Fund, II, LP
      Douglas Leighton
      312 Stuart Street, Third Floor
      Boston, MA  02116
      (617) 960-3570

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      Each party shall provide five (5) business days prior notice to the other
party of any change in address, phone number or facsimile number.

Article 7 Time

      Where this Note authorizes or requires the payment of money or the
performance of a condition or obligation on a Saturday or Sunday or a holiday in
which the United States Stock Markets ("US Markets") are closed ("Holiday"), or
authorizes or requires the payment of money or the performance of a condition or
obligation within, before or after a period of time computed from a certain
date, and such period of time ends on a Saturday or a Sunday or a Holiday, such
payment may be made or condition or obligation performed on the next succeeding
business day, and if the period ends at a specified hour, such payment may be
made or condition performed, at or before the same hour of such next succeeding
business day, with the same force and effect as if made or performed in
accordance with the terms of this Note. A "business day" shall mean a day on
which the US Markets are open for a full day or half day of trading.

Article 8 No Assignment

      This Note shall not be assigned.

Article 9 Rules of Construction.

      In this Note, unless the context otherwise requires, words in the singular
number include the plural, and in the plural include the singular, and words of
the masculine gender include the feminine and the neuter, and when the tense so
indicates, words of the neuter gender may refer to any gender. The numbers and
titles of sections contained in the Note are inserted for convenience of
reference only, and they neither form a part of this Note nor are they to be
used in the construction or interpretation hereof. Wherever, in this Note, a
determination of the Company is required or allowed, such determination shall be
made by a majority of the Board of Directors of the Company and, if it is made
in good faith, it shall be conclusive and binding upon the Company and the
Holder.

Article 10 Governing Law

      The validity, terms, performance and enforcement of this Note shall be
governed and construed by the provisions hereof and in accordance with the laws
of the Commonwealth of Massachusetts applicable to agreements that are
negotiated, executed, delivered and performed solely in the Commonwealth of
Massachusetts.

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Article 11 Litigation

      The parties to this agreement will submit all disputes arising under this
agreement to arbitration in Boston, Massachusetts before a single arbitrator of
the American Arbitration Association ("AAA"). The arbitrator shall be selected
by application of the rules of the AAA, or by mutual agreement of the parties,
except that such arbitrator shall be an attorney admitted to practice law in the
Commonwealth of Massachusetts. No party to this agreement will challenge the
jurisdiction or venue provisions as provided in this section.

Article 12 Conditions to Closing

      The Company shall have delivered the proper Collateral to the Holder
before Closing of this Note.

Article 13 Structuring Fee

      The Company shall pay fees associated with the transaction in the amount
of sixty-five thousand dollars ($65,000) directly from the Closing of this Note.

Article 14 Indemnification

      In consideration of the Holder's execution and delivery of this Agreement
and the acquisition and funding by the Holder of the Note hereunder and in
addition to all of the Company's other obligations under the documents
contemplated hereby, the Company shall defend, protect, indemnify and hold
harmless the Holder and all of its shareholders, officers, directors, employees,
counsel, and direct or indirect investors and any of the foregoing person's
agents or other representatives (including, without limitation, those retained
in connection with the transactions contemplated by this Agreement)
(collectively, the "Indemnities") from and against any and all actions, causes
of action, suits, claims, losses, costs, penalties, fees, liabilities and
damages, and expenses in connection therewith (irrespective of whether any such
Indemnitee is a party to the action for which indemnification hereunder is
sought), and including reasonable attorneys' fees and disbursements (the
"Indemnified Liabilities" ), incurred by any Indemnitee as a result of, or
arising out of, or relating to (i) any misrepresentation or breach of any
representation or warranty made by the Company in the Note, or any other
certificate, instrument or document contemplated hereby or thereby (ii) any
breach of any covenant, agreement or obligation of the Company contained in the
Note or any other certificate, instrument or document contemplated hereby or
thereby, except insofar as any such misrepresentation, breach or any untrue
statement, alleged untrue statement, omission or alleged omission is made in
reliance upon and in conformity with written information furnished to the
Company by, or on behalf of, the Holder or is based on illegal trading of the
Common Stock by the Holder. To the extent that the foregoing undertaking by the
Company may be unenforceable for any reason, the Company shall make the maximum
contribution to the payment and satisfaction of each of the Indemnified
Liabilities that is permissible under applicable law. The indemnity provisions
contained herein shall be in addition to any cause of action or similar rights
the Holder may have, and any liabilities the Holder may be subject to.

_______   _______                                       DNAP Note June 2005
  RG        DHL

                                       11
<PAGE>

Article 15 Investor Shares

      The Company shall issue twenty-five million (25,000,000) shares of
unregistered, restricted Common Stock to the Holder as an incentive for the
investment ("Shares"). The Shares shall be issued and delivered immediately to
the Holder and shall carry piggyback registration rights. The Investor's Shares
shall be deemed fully earned as of the date hereof. In the event the Shares are
not registered in the next registration statement, the Company shall pay to the
Holder, as a penalty, five million (5,000,000) additional shares of common stock
for each time a registration statement is filed and the Shares are not included.
The Holder retains the right to waive such penalty, in the event Holder chooses
to do so. Failure to do so will result in an Event of Default and the Holder may
elect to take the action outlined in Article 4. This Event of Default will
survive this Agreement until such time as the Shares are no longer under the
control of the Holder.

      The Holder acknowledges that the Company has plans to undergo a 1:20
reverse split.

Article 16 Use of Proceeds

For the acquisition of Biofrontera and general corporate working capital
purposes. This shall not to be used to pay down long-term debt to any financial
institution.

      Any misrepresentations shall be considered a breach of contract and
Default under this Agreement and the Holder may seek to take actions as
described under Article 4 of this Agreement.

      IN WITNESS WHEREOF, the Company has duly executed this Note as of the date
first written above.

                                        DNAPRINT GENOMICS, INC.

                                        By /s/ Richard Gabriel
                                        ----------------------------------------
                                        Name: Richard Gabriel
                                        Title: Chief Executive Officer

                                        DUTCHESS PRIVATE EQUITIES FUND, II, L.P.
                                        BY ITS GENERAL PARTNER DUTCHESS
                                        CAPITAL MANAGEMENT, LLC

                                        By: /s/ Douglas H. Leighton
                                        ----------------------------------------
                                        Name: Douglas H. Leighton
                                        Title: A Managing Member

_______   _______                                       DNAP Note June 2005
  RG        DHL

                                       12AutoCoded Document

[FACE OF
CERTIFICATE]
NUMBER
U
SEE REVERSE FOR CERTAIN DEFINITIONS
ECHO HEALTHCARE ACQUISITION CORP.

UNITS CONSISTING OF ONE SHARE OF COMMON STOCK AND ONE WARRANT TO PURCHASE
ONE SHARE OF COMMON
STOCK
U N I TS
CUSIP TO COME
This Certifies that
is the owner of ____________ Units. 

Each
Unit (“Unit”) consists of one (1) share of common stock, par value
$.0001 per share (“Common Stock”), of Echo Healthcare Acquisition
Corp., a Delaware corporation (the “Company”), and one warrant (the
“Warrant”). Each Warrant entitles the holder to purchase one (1) share
of Common Stock for $6.00 per share (subject to adjustment). Each Warrant will
become exercisable on the later of (i) the Company’s completion of a
merger, capital stock exchange, asset acquisition or other similar business
combination and (ii) , 2006, and will expire unless exercised before 5:00 p.m.,
New York City Time, on , 2009, or earlier upon redemption (the “Expiration
Date”). The Common Stock and Warrants comprising the Units represented by
this certificate are not transferable separately prior to , 2005, subject to
earlier separation in the discretion of Roth Capital Partners, LLC. The terms of
the Warrants are governed by a Warrant Agreement, dated as of , 2005, between
the Company and Corporate Stock Transfer, Inc., as Warrant Agent, and are
subject to the terms and provisions contained therein, all of which terms and
provisions the holder of this certificate consents to by acceptance hereof.
Copies of the Warrant Agreement are on file at the office of the Warrant Agent
at 3200 Cherry Creek South Drive, Suite 430, Denver, Colorado 80209 and are
available to any Warrant holder on written request and without cost.

This
certificate is not valid unless countersigned by the Transfer Agent and
Registrar of the Company. Witness the facsimile seal of the Company and the
facsimile signature of its duly authorized officers.

By
SECRETARY
[SEAL]
PRESIDENT

COUNTER SIGNED AND REGISTERED:
CORPORATE STOCK TRANSFER, INC.
TRANSFER AGENT AND REGISTRAR

BY
AUTHORIZED SIGNATURE

[REVERSE OF
CERTIFICATE]
Echo Healthcare Acquisition Corp.

The Company will furnish without
charge to each stockholder who so requests, a statement of the powers, designations,
preferences and relative, participating, optional or other special rights of each class
of stock or series thereof of the Company and the qualifications, limitations, or
restrictions of such preferences and/or rights. 

The
following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:
TEN COM – as tenants in common

TEN ENT – as tenants by the entireties
JT TEN – as joint tenants with
right of survivorship and not as tenants in common
UNIF GIFT MIN ACT–
(Cust) Custodian (Minor) under Uniform Gifts to Minors Act (State)
Additional
abbreviations may also be used though not in the above list.
For
value received, ___________________________ hereby sell, assign and transfer
unto
PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE

(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

Units represented by the within Certificate, and do hereby irrevocably
constitute and appoint ____________ Attorney to transfer the said Units on the
books of the within named Company with full power of substitution in the
premises.

Dated
Notice:
The signature to this assignment must correspond with the name as written upon
the face of the certificate in every particular, without alteration or
enlargement or any change whatever.

Signature(s)
Guaranteed:

THE
SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN
AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE
17Ad-15).

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