Document:

Filed by Bowne Pure Compliance

Exhibit 10.1

EXECUTIVE EMPLOYMENT AGREEMENT

THIS AMENDMENT NO. 3 TO EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered
into as of June 27, 2008 by and between ImaRx Therapeutics, Inc., a Delaware corporation (the
“Company”), and Bradford A. Zakes (“Executive”) and replaces the Amendment No. 2 to Executive
Employment Agreement between the parties dated January 1, 2008 and its predecessor agreements dated
February 1, 2007 and August 22, 2005 (together, the “Original Agreement”).

WITNESSETH:

WHEREAS, the Company desires to retain the services of Executive, and Executive desires to be
employed by the Company, on the terms and conditions of this Agreement.

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements set
forth herein, the Company and Executive, intending to be legally bound, hereby agree as follows:

1. Employment. The Company agrees to employ Executive as President and Chief
Executive Officer and Executive accepts such employment and agrees to perform full-time employment
services for the Company, subject to Section 3.2 of this Agreement and the Certificate of
Incorporation and Bylaws of the Company, as presently in effect and as amended from time to time
(the “Organizational Documents”), and the resolutions of the Board of Directors of the Company (the
“Board”), for the period and upon the other terms and conditions set forth in this Agreement.

2. Term. The term of Executive’s employment hereunder (the “Term”) commenced upon the
Executive’s initial employment start date under the Original Agreement and shall continue until
this Agreement is terminated as set forth in Section 5 below.

3. Position and Duties.

3.1 Service with the Company. During the Term of this Agreement, Executive agrees to
perform the duties of President and Chief Executive Officer of the Company and such other duties as
the Board may from time to time prescribe that are consistent with the duties of a President and
Chief Executive Officer of a company of the size and nature of the Company.

3.2 No Conflicting Duties. Executive hereby confirms that he is under no contractual
commitments inconsistent with his obligations set forth in this Agreement, and that during the Term
of this Agreement, he will not render or perform services, or enter into any contract to do so, for
any other corporation, firm, entity or person that are inconsistent with the provisions of this
Agreement or Executive’s fiduciary obligations to the Company. Except as otherwise provided
herein, Executive shall not serve as a director of any other corporation (except nonprofit organizations to the extent such service does not materially affect
Executive’s performance of his duties for the Company) without the prior approval of the Board of
Directors.

 

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4. Compensation and Benefits.

4.1 Retention Bonus Payment. Promptly following execution of this Agreement by each
of the parties hereto, the Company shall pay to Executive a lump sum cash retention bonus payment
in the amount of $290,000. In consideration for such payment, Executive agrees to remain in the
employ of the Company for a period of 12 months from the date of this Agreement. In the event that
Executive’s employment with the Company is terminated prior to the expiration of such 12 month
period and such termination is not incident to one or more of the events provided for in Section 7
(Change-in Control), Section 7.2 (Good Reason), Section 5.1 (Disability),
Section 5.2 (Death of Executive) or Section 5.5 (Without Cause), then Executive
shall repay to the Company that portion of the bonus equal to the product of the total bonus
payment multiplied by the fraction where the numerator is the number of months remaining on
Executive’s 12 month commitment and the denominator is 12.

4.2 Base Salary. (a) As compensation for all services to be rendered by Executive
under this Agreement, the Company shall pay to Executive during the Term an annual base salary of
$275,000 (the “Base Salary”). Subject to Section 4.1(b), the Base Salary shall be reviewed at
least annually and changed at the discretion of the Board (or its Compensation Committee),
provided, however, that the Base Salary may not be decreased without the written consent of the
Executive. The Company shall pay the Base Salary to Executive in accordance with the Company’s
normal payroll procedures and policies.

(b) If Executive’s Base Salary is increased at any time, it shall not thereafter be decreased
during the Term of this Agreement, unless such decrease is the result of a general reduction (on
the same percentage basis) affecting the base salaries of all other executive officers of the
Company and such decrease does not result in a Base Salary of less than the Base Salary set forth
in Section 4.1 above.

4.3 Annual Bonus. With respect to each full fiscal year until the Termination Date,
Executive shall be eligible to receive bonus awards aggregating up to 50% of Base Salary annually,
payable periodically based on the achievement of pre-determined milestones established from time to
time by the Board (or its Compensation Committee) pursuant to the Company’s Bonus Plan (as adopted
by the Board on October 18, 2007 and as such plan may be amended from time to time by the Board, in
its sole discretion).

4.4 Stock Options. (a) The Company has previously granted to Executive various stock
options to purchase shares of the Company’s common stock (the “Shares”), pursuant to the Company’s
2000 Stock Plan and/or the 2007 Performance Incentive Plan (the “Plans”). As a result of the
foregoing grants, the options currently held by Executive are as follows:

 

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	Grant	 	Tax	 	 	No. of	 	 	Exercise	 	 	% Vested as of	 
	Date	 	Character	 	 	Shares	 	 	Price	 	 	12/31/07	 
	08/22/05
	 	ISO	 	 	24,000	 	 	$	15.00	 	 	 	58	%
	12/14/05
	 	ISO	 	 	4,000	 	 	$	20.00	 	 	 	50	%
	12/12/06
	 	ISO	 	 	30,333	 	 	$	15.00	 	 	 	25	%
	07/31/07
	 	ISO	 	 	41,666	 	 	$	5.00	 	 	 	0	%
	09/07/07
	 	ISO	 	 	16,667	 	 	$	4.05	 	 	 	100	%
	12/18/07
	 	ISO	 	 	225,000	 	 	$	2.10	 	 	 	0	%

4.5 Participation in Benefit Plans. Executive shall be included to the extent
eligible thereunder in any and all plans of the Company providing general benefits for the
Company’s executive employees, including, without limitation, medical, dental, vision, short and
long term disability insurance, life insurance, 401(k) plan, sick days, vacation, and holidays, to
the extent the Company makes such plans or benefits available to its executive employees generally.
Executive’s participation in any such plan or program shall be subject to the provisions, rules,
and regulations applicable thereto. In addition, during the Term of this Agreement, Executive shall
be eligible to participate in all non-qualified deferred compensation and similar compensation,
incentive, bonus, profit sharing and stock plans offered, sponsored or established by Company on
substantially the same or a more favorable basis as any other employee of Company.

4.6 Business Expenses. In accordance with the Company’s policies established from
time to time, the Company will pay or reimburse Executive for all reasonable and necessary
out-of-pocket expenses incurred by him in the performance of his duties under this Agreement,
subject to the presentment of appropriate supporting documentation. During the Term of this
Agreement, the Company shall at its expense provide Executive with reasonable office space and
furnishings (including without limitation desk and lap top computers) at the Company’s principal
executive offices, and a cell telephone.

4.7 Key Man Life Insurance. During the Term of this Agreement, the Company shall have
the option of purchasing and paying the premiums for a “Key Man” life insurance policy relating to
Executive in a coverage amount determined by the Company, and the Company shall be named as the
beneficiary of such policy.

5. Termination.

5.1 Disability. At the Company’s election, Executive’s employment and this Agreement
shall terminate upon Executive’s becoming totally or permanently disabled for a period of ninety
(90) days or more in any twelve (12) month period. For purposes of this Agreement, the term
“totally or permanently disabled” or “total or permanent disability” means Executive’s inability on
account of sickness or accident, whether or not job-related, to engage in regularly or to perform
adequately his assigned duties under this Agreement and Executive is qualified and eligible to
receive disability benefits under the disability policies maintained by the Company for Executive.

 

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5.2 Death of Executive. Executive’s employment and this Agreement shall terminate
immediately upon the death of Executive.

5.3 Termination for Cause. The Company may terminate Executive’s employment and this
Agreement at any time for “Cause” (as hereinafter defined) immediately upon written notice to
Executive. As used herein, the term “Cause” shall mean that Executive shall have: (i) been
convicted of a felony; or (ii) committed an act of fraud, embezzlement, or breach of trust; or
(iii) committed an act of willful misconduct or gross negligence resulting in a material loss to
the Company; or (iv) materially violated any material written Company policy or rules of the
Company, unless cured by Executive within 30 days following written notice thereof to Executive; or
(v) refused to follow the reasonable written directions given by the Board or its designee or
materially breached any covenant or obligation under this Agreement or other agreement with the
Company, unless cured by Executive within 30 days following written notice thereof to Executive.

5.4 Resignation. Executive’s employment and this Agreement shall terminate on the
earlier of the date that is one (1) month following the written submission of Executive’s
resignation to the Company or the date such resignation is accepted by the Company.

5.5 Termination Without Cause. The Company may terminate Executive’s employment and
this Agreement without cause upon written notice to Executive. Termination “without cause” shall
mean termination of employment on any basis (including no reason or no cause) other than
termination of Executive’s employment hereunder pursuant to Sections 5.1, 5.2, 5.3, or 5.4.

5.6 Surrender of Records and Property. Upon termination of his employment with the
Company, Executive shall deliver promptly to the Company all credit cards, computer equipment,
cellular telephone, records, manuals, books, blank forms, documents, letters, memoranda, notes,
notebooks, reports, data, tables, calculations or copies thereof, that are the property of the
Company and that relate in any way to the business, strategies, products, practices, processes,
policies or techniques of the Company, and all other property, trade secrets and confidential
information of the Company, including, but not limited to, all documents that in whole or in part
contain any trade secrets or confidential information of the Company that in any of these cases are
in his possession or under his control, and Executive shall also remove all such information from
any personal computers that he owns or controls.

6. Compensation Upon the Termination of Executive’s Employment.

6.1 In the event that Executive’s employment and this Agreement are terminated pursuant to
Section 5.1 (Disability), 5.3 (Cause), or 5.4 (Resignation), then Executive shall be entitled to
receive Executive’s then current Base Salary through the date his employment is terminated, and
such other amounts that accrued prior to the termination date and are required to be paid to him
pursuant to any employee benefit plan in accordance with such plan and/or by law, but no other
compensation of any kind or amount.

 

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6.2 In the event Executive’s employment and this Agreement are terminated pursuant to Section
5.2 (Death), Executive’s beneficiary or a beneficiary designated by Executive in writing to the Company, or in the absence of such beneficiary, Executive’s
estate, shall be entitled to receive Executive’s then current Base Salary through the end of the
month in which his death occurs, and such other amounts that accrued prior to the termination date
and are required to be paid to him pursuant to any employee benefit plan in accordance with such
plan and/or by law, but no other compensation of any kind or amount.

6.3 Unless Section 7 applies, in the event Executive’s employment and this Agreement are
terminated by the Company pursuant to Section 5.5 (Without Cause) or by Executive for “Good Reason”
(as defined below), subject to Section 8 below, Executive shall receive accelerated vesting for
twelve (12) months from the date of Executive’s termination for all stock options granted by the
Company to Executive before or after the Commencement Date, and extension of the option exercise
period for an additional twelve (12) months beyond the period set forth in the governing option
documents for such exercise, provided, however, that the period for exercise of such stock options
shall not be extended beyond the date on which they would have terminated had Executive continued
to be employed by the Company. Executive shall receive no other compensation or benefits of any
kind.

6.4 The provisions of this Section 6 shall not affect Executive’s participation in or
terminating distributions and vested rights under, any pension, profit sharing, insurance or other
employee benefit plan of the Company to which Executive is entitled pursuant to the terms of such
plans.

7. Change in Control. In the event a Change in Control (as defined below) occurs
and, in the twelve month period preceding or following the Change in Control, Executive’s
employment and this Agreement are terminated by the Company or its successor, assigns or transferee
pursuant to Section 5.5 (Without Cause) or by Executive for “Good Reason” (as defined below), then
upon the occurrence of the last of these conditions (the “Trigger Date”), subject to Section 8
below, one hundred percent (100%) of Executive’s unvested options (whether granted before or after
the Commencement Date) as of the Trigger Date, shall automatically vest as of the Trigger Date and
the exercise period for all such stock options shall be extended an additional twelve (12) months
(but in any case not beyond the date on which they would have terminated had Executive continued to
be employed by the Company).

7.1 Definition of Change in Control. For purposes of this Agreement, a “Change in
Control” shall be deemed to have occurred if, at any time during the Term, any of the following
events occurs:

7.1.1 if the Company does not have a class of securities registered under Section 12 of the
Securities Exchange Act of 1934, as amended (the “Exchange Act”):

7.1.1.1 any person, as that term is used in Section 13(d) and Section 14(d)(2) of the
Exchange Act, becomes a beneficial owner (as defined in Rule 13d-3 under the Exchange Act or
any successor rule or regulation), directly or indirectly, of securities of the Company
representing 50% or more of the combined voting power of the Company’s then outstanding
Voting Stock, as defined below, provided, however, that for purposes of this
paragraph, the term “person” shall exclude (A) a trustee or other fiduciary holding
securities under an employee benefit plan of the Company or any of its subsidiaries, (B) a person who beneficially owns 25% or more of the Company’s
outstanding Voting Stock on the Effective Date, or (C) any person who becomes such a
beneficial owner in connection with a bona fide financing transaction.

 

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7.1.1.2 the Company is merged, consolidated or reorganized into or with another
corporation or other legal person (an “Acquiring Person”) or securities of the Company are
exchanged for securities of an Acquiring Person, and as a result of such merger,
consolidation, reorganization or exchange less than a majority of the combined voting power
of the then outstanding securities of the Acquiring Person immediately after such
transaction is held, directly or indirectly, in the aggregate by the holders of securities
entitled to vote generally in the election of directors (“Voting Stock”) of the Company
immediately prior to such transaction;

7.1.1.3 the Company, in any transaction or series of related transactions, sells or
otherwise transfers, directly or indirectly, all or substantially all of its assets, on a
consolidated basis, to an Acquiring Person, and less than a majority of the combined voting
power of the then outstanding securities of the Acquiring Person immediately after such sale
or transfer is held, directly or indirectly, in the aggregate by the holders of Voting Stock
of the Company immediately prior to such sale or transfer; or

7.1.1.4 during any period of two consecutive years, individuals who at the beginning of
any such period constitute the directors of the Company cease for any reason to constitute
at least a majority thereof, unless the election, or the nomination for election by the
Company’s stockholders, of each director of the Company first elected during such period was
approved by at least a majority vote of the directors of the Company then still in office
who were directors of the Company at the beginning of any such period;

or

7.1.2 if the Company has a class of securities registered under Section 12 of the Exchange
Act:

7.1.2.1 any person, as that term is used in Section 13(d) and Section 14(d)(2) of the
Exchange Act, becomes, is discovered to be, or files a report on Schedule 13D or 14D-1 (or
any successor schedule, form or report) disclosing that such person is, a beneficial owner
(as defined in Rule 13d-3 under the Exchange Act or any successor rule or regulation),
directly or indirectly, of securities of the Company representing 25% or more of the
combined voting power of the Company’s then outstanding Voting Stock, provided,
however, that for purposes of this paragraph, the term “person” shall exclude (A) a trustee
or other fiduciary holding securities under an employee benefit plan of the Company or any
of its subsidiaries, (B) a person who becomes such a beneficial owner in connection with
the Company’s initial public offering of common stock or (C) any person who was a
shareholder of the Company immediately prior to the Company’s initial public offering of
common stock; or

 

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7.1.2.2 any of the events described in Sections 7.1.1.2, 7.1.1.3 or 7.1.1.4 (the latter
being modified to refer to such a change of a majority of the Board of Directors during any
one year period).

Notwithstanding the foregoing, a transaction shall not constitute a Change in Control if its sole
purpose is to change the state of the Company’s incorporation or to create a holding company that
will be owned in substantially the same proportions by the persons who held the Company’s
securities immediately before such transaction.

7.2 Definition of Good Reason. As used in this Agreement, “Good Reason” means any of
the following: (i) a material reduction in Executive’s title, status, authority, or responsibility
at the Company, provided that a reduction of Executive to the title, authority and responsibilities
of Chief Operating Officer or any other “C level” office relating to a principal business function
or unit shall not of itself constitute Good Reason; or (ii) a material reduction in the salary or
other benefits in effect for the Executive, provided comparable reductions have not been made in
the salary or other benefits of the other members of senior management of the Company; or (iii)
except with Executive’s prior written consent, relocation of Executive’s principal place of
employment to a location more than 25 miles from the Company’s executive offices in Tucson,
Arizona; or (iv) ) any breach by the Company of its material obligations under this Agreement
unless such breach is cured within 30 days after written notice of breach from Executive.

8. Release. As a condition precedent to the Company’s obligation to provide Executive
with the acceleration of vesting of non-vested Stock Options as set forth in Section 6.3 or Section
7, Executive must first execute and deliver to the Company a mutual legal release in the form
attached hereto as Exhibit A, with such changes as the Company deems necessary in order to
maintain the breadth of such release in the event of changes in applicable laws, rules or
regulations, it being the intent of the parties that the release be as broad as possible.

9. Ventures. If, during the Term of this Agreement, Executive is engaged in or
associated with the planning or implementing of any project, program, or venture involving the
Company and a third party or parties, all rights in the project, program, or venture shall belong
to the Company and shall constitute a corporate opportunity belonging exclusively to the Company.
Except as approved in writing by the Board, Executive shall not be entitled to any interest in such
project, program, or venture or to any commission, finder’s fee, or other compensation in
connection therewith other than the Base Salary to be paid to Executive as provided in this
Agreement.

10. Restrictions.

10.1 Definitions. For purposes of this Agreement, the following terms shall have the
following meanings:

10.1.1 “Trade Secrets” means information that is not generally known about the Company
or its business, including without limitation about its products, recipes, projects, designs,
developmental or experimental work, computer programs, data bases, know-how, processes, business
partners, manufacturers, customers, suppliers, business plans,

 

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marketing plans and strategies, financial or personnel information, and information obtained
from third parties under confidentiality agreements. “Trade Secrets” also means formulas,
patterns, compilations, programs, devices, methods, techniques, or processes that derive
independent economic value, actual or potential, from not being generally known to the public or to
other persons who can obtain economic value from its disclosure or use, and is the subject of
efforts that are reasonable under the circumstances to maintain its secrecy. In particular, the
parties agree and acknowledge that the following list, which is not exhaustive and is to be broadly
construed, enumerates some of the Company’s Trade Secrets, the disclosure of which would be
wrongful and would cause irreparable injury to the Company: (i) pharmaceutical manufacturing; (ii)
formulation technology; (iii) pricing information; (iv) product development, marketing, sales,
customer, manufacturer and supplier information related to any Company product or service available
commercially or in any stage of development during Executive’s employment with the Company; and (v)
Company marketing and business strategies, ideas, and concepts. Executive acknowledges that the
Company’s Trade Secrets were and are designed and developed by the Company at great expense and
over lengthy periods of time, are secret, confidential, and unique, and constitute the exclusive
property of the Company.

10.1.2 “Restricted Field” means the business of developing, manufacturing, licensing
and selling (i) treatment of vascular thrombosis comprising thrombolytic drugs with or without
bubbles and ultrasound, and (ii) oxygen delivery with bubbles or fluorocarbon emulsions.

10.1.3 “Non-Competition Period” means a period of 12 months after the termination of
Executive’s employment with the Company unless a court of competent jurisdiction determines that
that Period is unenforceable under applicable law because it is too long, in which case the
Non-Competition Period shall be for the longest of the following periods that the court determines
is reasonable under the circumstances: 11 months, 10 months, 9 months, 8 months, 7 months, or 6
months after the termination of Executive’s employment with the Company.

10.1.4 “Business Territory” means the entire United States, unless a court of
competent jurisdiction determines that that geographic scope is unenforceable under applicable law
because it is too broad, in which case the Business Territory shall be amended by eliminating
geographical areas and states from the following list until the Business Territory is determined to
be reasonable: Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware,
District of Columbia, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky,
Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana,
Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota,
Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas,
Utah, Vermont, Virginia, Washington, Washington, District of Columbia, West Virginia, Wisconsin,
Wyoming, Pima County, Arizona, Maricopa County, Arizona, Tucson, Arizona, Phoenix, Arizona. The
parties acknowledge and agree that if any of the geographic areas or States listed above are
required by law to be eliminated, it would be fair and appropriate to do so in the inverse order of
the volume of revenue received or projected to be received by the Company from such area or State
at the time of determination.

 

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10.1.5 “Non-Solicitation Period” means a period of 12 months after the termination of
Executive’s employment with the Company.

10.2 Non-Disclosure Obligations. Executive shall not at any time during the period
specified in Section 4.A. of the Invention and Confidential Information Agreement attached hereto
as Exhibit B, without the express written consent of a superior officer or the Board of the
Company, publish, disclose, or divulge to any person, firm or corporation, or use directly or
indirectly for the Executive’s own benefit or for the benefit of any person, firm, corporation or
entity other than the Company, any Trade Secrets of the Company.

10.3 Non-Competition Obligations. Executive acknowledges the substantial amount of
time, money, and effort that the Company has spent and will spend in developing its products and
other strategically important information (including Trade Secrets), and agrees that during
Executive’s employment with the Company hereunder and during the Non-Competition Period, Executive
will not, alone or with others, directly or indirectly, as an employee, agent, consultant, advisor,
owner, manager, lender, officer, director, employee, partner, stockholder, or otherwise, engage in
any Restricted Field activities in the Business Territory, nor have any such relationship with any
person or entity that engages in Restricted Field activities in the Business Territory; provided,
however, that nothing in this Agreement will prohibit Executive from owning a passive investment of
less than one percent of the outstanding equity securities of any company listed on any national
securities exchange or traded actively in any national over-the-counter market so long as Executive
has no other relationship with such company in violation of this Agreement. The Non-Competition
Period set forth in this Section 10.3 shall be tolled during any period in which the Executive is
in breach of the restriction set forth in this Section 10.3. 

10.4 Agreement Not to Solicit Customers. Executive agrees that during Executive’s
employment with the Company hereunder and during the Non-Solicitation Period, Executive will not,
either directly or indirectly, on Executive’s own behalf or in the service or on behalf of others,
solicit, divert, or appropriate, or attempt to solicit, divert, or appropriate, to any business
that engages in Restricted Field activities in the Business Territory (i) any person or entity
whose account with the Company was sold or serviced by or under the supervision of Executive during
the twelve (12) months preceding the termination of such employment, or (ii) any person or entity
whose account with the Company has been directly solicited at least twice by the Company within the
year preceding the termination of Executive’s employment (the “Customers”). The Non-Solicitation
Period set forth in this Section 10.4 shall be tolled during any period in which the Executive is
in breach of the restriction set forth in this Section 10.4.

10.5 Agreement Not to Solicit Employees. Executive agrees that during Executive’s
employment with the Company hereunder and during the Non-Solicitation Period, Executive will not,
either directly or indirectly, on Executive’s own behalf or in the service or on the behalf of
others solicit, divert, or hire away, or attempt to solicit, divert, or hire away any person then
employed by the Company, nor encourage anyone to leave the Company’s employ. The Non-Solicitation
Period set forth in this Section 10.5 shall be tolled during any period in which the Executive is
in breach of the restriction set forth in this Section 10.5.

10.6 Defamatory Statements. Executive agrees that during Executive’s employment with
the Company hereunder and thereafter, he will not, either directly or indirectly, defame the reputation, character, or image of the Company or its products, services,
employees, directors, or officers.

 

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10.7 Reasonableness. Executive and the Company agree that the covenants set forth in
this Agreement are appropriate and reasonable when considered in light of the nature and extent of
the Company’s business. Executive further acknowledges and agrees that: (i) the Company has a
legitimate interest in protecting the Company’s business activities and its current, pending, and
potential Trade Secrets; (ii) the covenants set forth herein are not oppressive to Executive and
contain reasonable limitations as to time, scope, geographical area, and activity; (iii) the
covenants do not harm in any manner whatsoever the public interest; (iv) Executive’s chosen
profession, trade, or business is in manufacturing, developing, and marketing pharmaceutical drugs,
products and devices (the “Profession”); (v) the Restricted Field is only a very small or limited
part of the Profession, and Executive can work in many different jobs in Executive’s Profession
besides those in the Restricted Field; (vi) the covenants set forth herein do not completely
restrain Executive from working in Executive’s Profession, and Executive can earn a livelihood in
Executive’s Profession without violating any of the covenants set forth herein; (vii) Executive has
received and will receive substantial consideration for agreeing to such covenants, including
without limitation the consideration to be received by Executive under this Agreement; (viii) if
Executive were to work for a competing company that engages in activities in the Restricted Field,
there would be a substantial risk that Executive would inevitably disclose Trade Secrets to that
company; (ix) the Company competes with other companies that engage in Restricted Field activities
in the Business Territory, and if Executive were to engage in prohibited activities in the
Restricted Field within the Business Territory, it would harm the Company; (x) the Company expends
considerable resources on hiring, training, and retaining its employees and if Executive were to
engage in prohibited activities during the Non-Solicitation Period, it would harm the Company; and
(xi) the Company expends considerable resources acquiring, servicing, and retaining its Customers
and if Executive were to engage in prohibited activities during the Non-Solicitation Period, it
would harm the Company.

11. Other Agreements. Executive reaffirms Executive’s obligations set forth in the
Employee Agreement Concerning Invention Assignment Non-Disclosure and Non-Competition attached
hereto as Exhibit B, which Executive has previously executed and delivered; provided, that
in the event of any inconsistency between Exhibit B and the terms of Section 10 above, the
terms of Section 10 shall be controlling. Executive further acknowledges and agrees that he will
comply with all other Company policies and procedures. The terms of any Indemnity Agreement
between the Executive and Company will also continue in full force and effect.

12. Assignment. This Agreement shall not be assignable, in whole or in part, by
either party without the written consent of the other party, except that the Company may, without
the consent of Executive, assign its rights and obligations under this Agreement to any
corporation, firm or other business entity (i) with or into which the Company may merge or
consolidate, (ii) to which the Company may sell or transfer all or substantially all of its assets
or (iii) of which at least a majority of the equity investment and of the voting control is owned,
directly or indirectly, by, or is under common ownership with, the Company. Upon such assignment
by the Company, the Company shall exercise commercially reasonable efforts to obtain the assignees’
written agreement enforceable by Executive to assume and perform, from and after the date of such assignment, the terms, conditions, and provisions imposed by this
Agreement upon the Company.

 

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13. Other Provisions.

13.1 Governing Law. This Agreement is made under and shall be governed by and
construed in accordance with the laws of the State of Arizona without reference to conflicts of law
provisions thereof.

13.2 Injunctive Relief. Executive agrees that it would be difficult to compensate the
Company fully for damages for any violation of the provisions of this Agreement. Accordingly,
Executive specifically agrees that the Company shall be entitled to temporary and permanent
injunctive relief to enforce the provisions of this Agreement. This provision with respect to
injunctive relief shall not, however, diminish the right of the Company to claim and recover
damages in addition to injunctive relief.

13.3 Prior Agreements. This Agreement and its exhibits contain the entire agreement
of the parties relating to the subject matter hereof and supersedes all prior agreements and
understandings with respect to such subject matter, and the parties hereto have made no agreements,
representations, or warranties relating to the subject matter of this Agreement which are not set
forth herein.

13.4 Withholding Taxes and Right of Offset. The Company may withhold from all
payments and benefits under this Agreement all federal, state, city, or other taxes as shall be
required pursuant to any law or governmental regulation or ruling. Executive agrees that the
Company may offset any payments owed to Executive pursuant to this Agreement by any amounts owed by
Executive to the Company.

13.5 Amendments. No amendment or modification of this Agreement shall be deemed
effective unless made in writing signed by Executive and the Company.

13.6 No Waiver. No term or condition of this Agreement shall be deemed to have been
waived nor shall there be any estoppel to enforce any provisions of this Agreement, except by a
statement in writing signed by the party against whom enforcement of the waiver or estoppel is
sought. Any written waiver shall not be deemed a continuing waiver unless specifically stated,
shall operate only as to the specific term or condition waived, and shall not constitute a waiver
of such term or condition for the future or as to any act other than that specifically waived.

13.7 Severability. To the extent any provision of this Agreement shall be invalid or
unenforceable, it shall be considered deleted from this Agreement and the remainder of such
provision and of this Agreement shall be unaffected and shall continue in full force and effect.

13.8 Indemnification. Executive shall be entitled as an officer and director to be
indemnified by the Company under the Organizational Documents, as set forth therein, and to receive
the benefits, if any, of any director and officer liability insurance obtained by the Company in its discretion from time to time, subject to the terms, provisions and conditions
of any such insurance.

 

11

 

13.9 Headings. The headings in this Agreement are included solely for reference
purposes and shall not be considered in the interpretation or construction of this Agreement.

13.10 Notices. All notices, requests, demands and other communications under this
Agreement shall be in writing and shall be delivered personally, by overnight courier or similar
means, by United States certified or registered mail, return receipt requested, postage prepaid, or
sent by facsimile transmission with written confirmation of receipt, at the addresses specified
below or such other addresses as the parties may designate by like notice. Any such notice shall
be effective upon receipt if delivered personally, by overnight courier or by United States
certified or registered mail, or on the next business day following transmittal if sent by
facsimile transmission.

	 	 	 	 	 
	 

	 	If to the Company:
	 	ImaRx Therapeutics, Inc.
	 

	 	 	 	1635 East 18th Street
	 

	 	 	 	Tucson, AZ 85719 
	 

	 	 	 	Attn: Chairman of the Board
	 

	 	 	 	Telephone: 520-770-1259 
	 

	 	 	 	Facsimile: 520-791-2437 
	 
	 	 	 	 
	 

	 	copy to:
	 	DLA Piper
	 

	 	 	 	701 Fifth Ave., Suite 7000 
	 

	 	 	 	Seattle, Washington 98104 
	 

	 	 	 	Attn: John M. Steel, Esq.
	 

	 	 	 	Telephone: (206) 839-4800 
	 

	 	 	 	Facsimile: (206) 839-4801 
	 
	 	 	 	 
	 

	 	If to Executive:
	 	Bradford A. Zakes
	 
	 	 	 	 
	 

	 	 	 	Telephone 520-975-5024 

13.11 No Mitigation Obligation. It will be difficult, and may be impossible, for
Executive to find reasonably comparable employment following the termination of Executive’s
employment with the Company, and the noncompetition covenant contained in Section 10 hereof will
further limit the employment opportunities for Executive. Accordingly, the parties hereto
expressly agree that the payments provided for in Section 6.3 and Section 7 by the Company to
Executive will be liquidated damages, and that Executive shall not be required to seek other
employment, or otherwise, to mitigate any payment provided for hereunder.

13.12 Remedies Cumulative. Remedies under this Agreement of either party hereto are
in addition to any remedy or remedies to which such party is entitled or may become entitled at law
or in equity.

 

12

 

13.13 Attorneys’ Fees. In the event suit is brought to enforce the terms of this
Agreement or to collect any moneys due hereunder, or to collect money damages for breach hereof,
the prevailing party shall be entitled to recover, in addition to any other remedy, reimbursement
for reasonable attorneys’ fees, court costs, costs of investigation and other related expenses
incurred in connection therewith.

13.14 Counterparts. This Agreement may be executed in any number of counterparts, all
such counterparts shall be deemed to constitute one and the same instrument, and each of said
counterparts shall be deemed an original hereof.

13.15 Survivability. Sections 4.3, 6, 7, 8, 10 and 13 of this Agreement shall survive
the termination of this Agreement and the termination of Executive’s employment with the Company.

IN WITNESS WHEREOF, the parties have executed this Agreement as of the day and year first set
forth above.

	 	 	 	 	 	 	 
	 	 	“Company”:	 	ImaRx Therapeutics, Inc.
	 
	 	 	 	 
	 
	 	 	 	/s/
Richard Love 
	 	 	 	 	 
	 

	 	 	 	By:	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name:	 	Richard Love 
	 

	 	 	 	 	 	 
	 

	 	 	 	Title:	 	Chairman 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	“Executive”:	 	/s/ Bradford A. Zakes 
	 	 	 	 	
 
	 	 	 	 	Bradford A. Zakes

 

13

 

Exhibit A

Form of Release

[Needs to be attached]

 

 

 

Exhibit B

Employee Agreement Concerning Invention Assignment

Non-Disclosure and Non-Competition

[Needs to be attached]Filed by Bowne Pure Compliance

EXHIBIT 10.1

AMENDED AND RESTATED

LOAN AND SECURITY AGREEMENT

This AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT is entered into as of June 30, 2008, by and
between COMERICA BANK (“Bank”) and SAFEGUARD DELAWARE, INC. (“Safeguard Delaware”) and SAFEGUARD
SCIENTIFICS (DELAWARE), INC. (“SSDI”; SSDI and Safeguard Delaware are sometimes referred to,
individually, as a “Borrower” and collectively, as the “Borrowers”).

RECITALS

A. Borrowers and Bank are parties to that certain Loan Agreement dated as of May 10, 2002, as
amended from time to time, including without limitation by a First Amendment to Loan Agreement
dated as of May 9, 2003, a Second Amendment to Loan Agreement dated as of February 12, 2004, a
Third Amendment to Loan Agreement dated as of May 8, 2004, a Fourth Amendment to Loan Agreement
dated as of September 30, 2004, a Fifth Amendment to Loan Agreement dated as of May 2, 2005, a
Sixth Amendment to Loan Agreement dated as of August 1, 2005, a Seventh Amendment to Loan Agreement
dated as of May 4, 2006, an Eighth Amendment to Loan Agreement dated as of February 28, 2007 and a
Ninth Amendment to Loan Agreement dated as of May 2, 2007 (collectively, the “Original Agreement”).

B. Borrowers and Bank wish to amend and restate the terms of the Original Agreement. This
Agreement sets forth the terms on which Bank will advance credit to Borrowers and Borrowers will
repay the amounts owing to Bank.

AGREEMENT

The parties agree as follows:

1. DEFINITIONS AND CONSTRUCTION.

1.1 Definitions. As used in this Agreement, all capitalized terms shall have the definitions
set forth on Exhibit A. Any term used in the Code and not defined herein shall have the meaning
given to the term in the Code.

1.2 Accounting Terms. Any accounting term not specifically defined on Exhibit A shall be
construed in accordance with GAAP and all calculations shall be made in accordance with GAAP. The
term “financial statements” shall include the accompanying notes and schedules.

2. LOAN AND TERMS OF PAYMENT.

2.1 Credit Extensions.

(a) Promise to Pay. Each Borrower promises to pay to Bank, in lawful money of the United
States of America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to
Borrowers, together with interest on the unpaid principal amount of such Credit Extensions at rates
in accordance with the terms hereof.

(b) Advances Under Revolving Line.

 

1

 

(i) Amount. Subject to and upon the terms and conditions of this Agreement, (1) Borrowers may
request Advances at any time before the Revolving Maturity Date in an aggregate
amount not to exceed the Revolving Line minus (x) the face amount of outstanding Letters of
Credit and minus (y) the face amount of outstanding Partner Company Guaranties (such resulting
aggregate amount, the “Revolving Limit”), and (2) amounts borrowed pursuant to this Section 2.1(b)
may be repaid and reborrowed at any time prior to the Revolving Maturity Date, at which time all
Advances under this Section 2.1(b) shall be immediately due and payable. Borrowers may prepay any
Advances without penalty or premium. If at any time the aggregate outstanding Advances made under
this Section exceed the Revolving Limit, Borrowers shall immediately pay Bank the excess in cash.
Prior to the Revolving Maturity Date, Borrowers shall secure in cash all obligations under any
outstanding Partner Company Guaranties on terms acceptable to Bank.

(ii) Form of Request. Whenever Borrowers desire an Advance, a Borrower will notify Bank by
facsimile transmission or telephone no later than 3:30 p.m. Eastern time (1:30 p.m. Pacific time
for wire transfers), on the Business Day prior to the Business Day that the Advance is to be made.
Each such notification shall be promptly confirmed by a Payment/Advance Form in substantially the
form of Exhibit C. Bank is authorized to make Advances under this Agreement, based upon
instructions received from a Responsible Officer or a designee of a Responsible Officer, or without
instructions if in Bank’s discretion such Advances are necessary to meet Obligations which have
become due and remain unpaid. Bank shall be entitled to rely on any telephonic notice given by a
person who Bank reasonably believes to be a Responsible Officer or a designee thereof, and
Borrowers shall indemnify and hold Bank harmless for any damages or loss suffered by Bank as a
result of such reasonable reliance. Bank will credit the amount of Advances made under this
Section 2.1(b) to a Borrower’s deposit account

(iii) Letter of Credit Sublimit. Subject to availability within the Revolving Limit, and in
reliance on the representations and warranties of Borrowers set forth herein, at any time and from
time to time from the date hereof through the Business Day immediately prior to the Revolving
Maturity Date, Bank shall issue for the account of Borrowers such Letters of Credit as a Borrower
may request by delivering to Bank a duly executed letter of credit application on Bank’s standard
form; provided, however, that the outstanding and undrawn amounts under all such Letters of Credit
(i) shall not at any time exceed $10,000,000, and (ii) shall be deemed to constitute Advances for
the purpose of calculating the Revolving Limit. Any drawn but unreimbursed amounts under any
Letters of Credit shall be charged as Advances against the Revolving Line. All Letters of Credit
shall be in form and substance acceptable to Bank in its sole discretion and shall be subject to
the terms and conditions of Bank’s form application and letter of credit agreement. Borrowers will
pay any standard issuance and other fees that Bank notifies a Borrower it will charge for issuing
and processing Letters of Credit, including Bank’s fee equal to 1.5% per annum of the face amount
of each Letter of Credit, payable annually in advance (provided that for Letters of Credit
outstanding on the date hereof, such 1.5% fee shall only be assessed when such Letters of Credit
are renewed, if ever). Prior to the Revolving Maturity Date, Borrowers shall secure in cash all
obligations under any outstanding Letters of Credit on terms acceptable to Bank.

2.2 Interest Rates, Payments, and Calculations.

(a) Interest Rates. Except as set forth in Section 2.2(b), the Advances shall bear interest,
on the outstanding daily balance thereof, at a variable rate equal to the Prime Rate.

(b) Late Fee; Default Rate. If any payment is not made within 10 days after the date such
payment is due, Borrowers shall pay Bank a late fee equal to the lesser of (i) 5% of the amount of
such unpaid amount or (ii) the maximum amount permitted to be charged under applicable law. All
Obligations shall bear interest, from and after the occurrence and during the continuance of an
Event of Default, at a rate equal to five percentage points (5%) above the interest rate applicable
immediately prior to the occurrence of the Event of Default.

(c) Payments. Interest hereunder shall be due and payable on the first calendar day of each
month during the term hereof. Bank shall, at its option, charge such interest, all Bank Expenses,
and all Periodic Payments against any of Borrower’s deposit accounts or against the Revolving Line,
in which case those amounts shall thereafter accrue interest at the rate then applicable hereunder.
Any interest not paid when due shall be compounded by becoming a part of the Obligations, and such
interest shall thereafter accrue interest at the rate then applicable hereunder.

 

2

 

(d) Computation. In the event the Prime Rate is changed from time to time hereafter, the
applicable rate of interest hereunder shall be increased or decreased, effective as of the day the
Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest
chargeable under the Loan Documents shall be computed on the basis of a 360 day year for the actual
number of days elapsed.

2.3 Crediting Payments. Prior to the occurrence of an Event of Default, Bank shall credit a
wire transfer of funds, check or other item of payment to such deposit account or Obligation as a
Borrower specifies. After the occurrence of an Event of Default, Bank shall have the right, in its
sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment
Bank may receive to conditionally reduce Obligations, but such applications of funds shall not be
considered a payment on account unless such payment is of immediately available federal funds or
unless and until such check or other item of payment is honored when presented for payment.
Notwithstanding anything to the contrary contained herein, any wire transfer or payment received by
Bank after 12:00 noon Pacific time shall be deemed to have been received by Bank as of the opening
of business on the immediately following Business Day. Whenever any payment to Bank under the Loan
Documents would otherwise be due (except by reason of acceleration) on a date that is not a
Business Day, such payment shall instead be due on the next Business Day, and additional fees or
interest, as the case may be, shall accrue and be payable for the period of such extension.

2.4 Fees. Borrowers shall pay to Bank the following:

(a) Unused Commitment Fee. A commitment fee equal to 0.125% of the difference between the
Revolving Line and the average Daily Balance for each quarter, which fee shall be paid quarterly in
arrears, provided that Bank shall waive such fee for each quarter in which Borrowers, collectively,
maintain an average Daily Balance greater than $18,750,000 in deposit accounts with Bank.

(b) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date,
and, after the Closing Date, all Bank Expenses, as and when they become due.

2.5 Term. This Agreement shall become effective on the Closing Date and, subject to Section
14.8, shall continue in full force and effect for so long as any Obligations remain outstanding or
Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding the
foregoing, Bank shall have the right to terminate its obligation to make Credit Extensions under
this Agreement immediately and without notice upon the occurrence and during the continuance of an
Event of Default.

3. CONDITIONS OF LOANS.

3.1 Conditions Precedent to Initial Credit Extension. The obligation of Bank to make the
initial Credit Extension is subject to the condition precedent that Bank shall have received, in
form and substance satisfactory to Bank, the following:

(a) this Agreement;

(b) an officer’s certificate of Borrower with respect to incumbency and resolutions
authorizing the execution and delivery of this Agreement;

(c) a UCC financing statement;

(d) an amendment and affirmation of guaranty of the Guarantor;

(e) payment of the fees and Bank Expenses then due specified in Section 2.44;

(f) current SOS Reports indicating that except for Permitted Liens, there are no other
security interests or Liens of record on the Borrower’s property;

 

3

 

(g) current financial statements, company prepared consolidated and consolidating balance
sheets and income statements for the most recently ended month in accordance with Section 6.2, and
such other updated financial information as Bank may reasonably request;

(h) current Compliance Certificate in accordance with Section 6.2;

(i) a Collateral Information Certificate; and

(j) such other documents or certificates, and completion of such other matters, as Bank may
reasonably deem necessary or appropriate.

Notwithstanding the delivery of a UCC financing statement in accordance with Section 3.1(c),
Bank shall not file such financing statement until an Event of Default has occurred.

3.2 Conditions Precedent to all Credit Extensions. The obligation of Bank to make each Credit
Extension, including the initial Credit Extension, is further subject to the following conditions:

(a) timely receipt by Bank of the Payment/Advance Form as provided in Section 2.1;

(b) the balance of Borrowers’ cash and Cash Equivalents are such that Borrowers will be in
compliance with Section 6.6 both before and after the making of the requested Credit Extension; and

(c) the representations and warranties contained in Section 5 shall be true and correct in all
material respects on and as of the date of such Payment/Advance Form and on the effective date of
each Credit Extension as though made at and as of each such date, and no Event of Default shall
have occurred and be continuing, or would exist after giving effect to such Credit Extension
(provided, however, that those representations and warranties expressly referring to another date
shall be true, correct and complete in all material respects as of such date). The making of each
Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of
such Credit Extension as to the accuracy of the facts referred to in this Section 3.2.

4. CREATION OF SECURITY INTEREST.

4.1 Grant of Security Interest. Each Borrower hereby grants to Bank a security interest in
the Collateral, as security for the prompt performance of the Obligations. Upon the occurrence and
during the continuance of an Event of Default, Bank shall have the right to exercise all such
rights as a secured party under the Code as it, in its sole judgment, shall deem necessary or
appropriate, including without limitation the right to apply the Collateral against the
Obligations. Except as set forth in the Schedule, such security interest constitutes a valid,
first priority security interest in the presently existing Collateral, and will constitute a valid,
first priority security interest in later-acquired Collateral. Notwithstanding any termination,
Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations are
outstanding, but only to the extent of such Obligations. Each Borrower authorizes Bank to hold
balances maintained by a Borrower or Borrowers in accounts (including without limitation money
market accounts and deposit accounts) and certificates of deposit at Bank up to the aggregate
outstanding balance of the Credit Extensions in pledge and to decline to honor any checks, drafts
or other items of payment or directions to wire or otherwise transfer funds from Bank (and agrees
that any accounts maintained at Bank’s Affiliates will be subject to Bank’s right to direct such
Affiliate or securities intermediary not to honor payment or transfer instructions), if and to the
extent that after giving effect to the payment of any such item or transfer of such funds or
assets, Borrowers would not (in Bank’s sole discretion) be in compliance with this Agreement
including without limitation Section 6.6.

5. REPRESENTATIONS AND WARRANTIES.

Each Borrower represents and warrants as follows:

5.1 Due Organization and Qualification. Borrower and each Subsidiary is a corporation duly
existing under the laws of the state in which it is incorporated and qualified and licensed to do
business in any state in which the conduct of its business or its ownership of property requires that it be so
qualified, except where the failure to do so would not reasonably be expected to cause a Material
Adverse Effect.

 

4

 

5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the Loan
Documents are within Borrower’s powers, have been duly authorized, and are not in conflict with nor
constitute a breach of any provision contained in either Borrower’s Certificate of Incorporation or
Bylaws, nor will they constitute an event of default under any material agreement by which Borrower
is bound. Borrower is not in default under any agreement by which it is bound, except to the
extent such default would not reasonably be expected to cause a Material Adverse Effect.

5.3 No Prior Encumbrances. The Collateral is free and clear of Liens, adverse claims, and
restrictions on transfer or pledge except for Permitted Liens. Except as set forth in the
Schedule, none of the Collateral is maintained or invested with a Person other than Bank or Bank’s
Affiliates.

5.4 Name; Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower
has not done business under any name other than that specified on the signature page hereof, and
its exact legal name is as set forth in the first paragraph of this Agreement. The chief executive
office of Borrower is located in the Chief Executive Office State at the address indicated in
Section 10 hereof.

5.5 Litigation. Except as set forth in the Schedule, there are no actions or proceedings
pending by or against Borrower or any Subsidiary before any court or administrative agency in which
a likely adverse decision would reasonably be expected to have a Material Adverse Effect.

5.6 No Material Adverse Change in Financial Statements. All consolidated and consolidating
financial statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank
fairly present in all material respects Borrower’s consolidated and consolidating financial
condition as of the date thereof and Borrower’s consolidated and consolidating results of
operations for the period(s) then ended. There has not been a material adverse change in the
consolidated or in the consolidating financial condition of Borrower since the date of the most
recent of such financial statements submitted to Bank.

5.7 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as
they mature; the fair saleable value of Borrower’s assets (including goodwill minus disposition
costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small
capital after the transactions contemplated by this Agreement.

5.8 Compliance with Laws and Regulations. Borrower and each Subsidiary have met the minimum
funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. No
event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely
to result in Borrower’s incurring any liability that could have a Material Adverse Effect.
Borrower is not an “investment company” or a company “controlled” by an “investment company” within
the meaning of the Investment Company Act of 1940. Borrower is not engaged principally, or as one
of the important activities, in the business of extending credit for the purpose of purchasing or
carrying margin stock (within the meaning of Regulations T and U of the Board of Governors of the
Federal Reserve System). Borrower has complied in all material respects with all the provisions of
the Federal Fair Labor Standards Act. Borrower is in compliance with all environmental laws,
regulations and ordinances except where the failure to comply is not reasonably likely to have a
Material Adverse Effect. Borrower has not violated any statutes, laws, ordinances or rules
applicable to it, the violation of which would reasonably be expected to have a Material Adverse
Effect. Borrower and each Subsidiary have filed or caused to be filed all tax returns required to
be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected
therein except those being contested in good faith with adequate reserves under GAAP or where the
failure to file such returns or pay such taxes would not reasonably be expected to have a Material
Adverse Effect.

5.9 Government Consents. Borrower and each Subsidiary have obtained all consents, approvals
and authorizations of, made all declarations or filings with, and given all notices to, all
governmental authorities that are necessary for the continued operation of Borrower’s business as
currently conducted, except where the failure to do so would not reasonably be expected to cause a
Material Adverse Effect.

 

5

 

5.10 Full Disclosure. No representation, warranty or other statement made by Borrower in any
certificate or written statement furnished to Bank taken together with all such certificates and
written statements furnished to Bank contains any untrue statement of a material fact or omits to
state a material fact necessary in order to make the statements contained in such certificates or
statements not misleading, it being recognized by Bank that the projections and forecasts provided
by Borrower in good faith and based upon reasonable assumptions are not to be viewed as facts and
that actual results during the period or periods covered by any such projections and forecasts may
differ from the projected or forecasted results.

6. AFFIRMATIVE COVENANTS.

Each Borrower covenants that, until payment in full of all outstanding Obligations, and for so
long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do all of
the following:

6.1 Good Standing and Government Compliance. Borrower shall maintain its and each of its
Subsidiaries’ corporate existence and good standing in the Borrower State, shall maintain
qualification and good standing in each other jurisdiction in which the failure to so qualify would
reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the
organizational identification number issued to Borrower by the authorities of the state in which
Borrower is organized, if applicable. Borrower shall meet, and shall cause each Subsidiary to
meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject
to ERISA. Borrower shall comply in all material respects with all applicable environmental laws,
and maintain all material permits, licenses and approvals required thereunder where the failure to
do so would reasonably be expected to have a Material Adverse Effect. Borrower shall comply, and
shall cause each Subsidiary to comply, with all statutes, laws, ordinances and government rules and
regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to
maintain, in force all licenses, approvals and agreements, the loss of which or failure to comply
with which would reasonably be expected to have a Material Adverse Effect.

6.2 Financial Statements, Reports, Certificates.

(a) Borrowers shall deliver to Bank: as soon as available, but in any event within forty five
(45) days after the last day of each fiscal quarter ending March 31, June 30 and September 30 (or
such longer period of time as may be afforded by the Securities and Exchange Commission pursuant to
Rule 12b-25), (i) Guarantor’s report on Form 10-Q filed or required to be filed with the Securities
and Exchange Commission, (ii) Guarantor-prepared consolidating financial statements of Guarantor
and its Subsidiaries prepared in accordance with GAAP, consistently applied, and (iii) a Compliance
Certificate certified as of the last day of the applicable quarter and signed by a Responsible
Officer in substantially the form of Exhibit D hereto;

(b) Borrowers shall deliver to Bank: as soon as available, but in any event within ninety
(90) days after the end of each Borrower’s fiscal year (or such longer period of time as may be
afforded by the Securities and Exchange Commission pursuant to Rule 12b-25), (i) Guarantor’s report
on Form 10-K filed or required to be filed with the Securities and Exchange Commission, (ii)
Guarantor-prepared consolidating financial statements of Guarantor and Borrowers prepared in
accordance with GAAP, consistently applied, and (iii) a Compliance Certificate in substantially the
form of Exhibit D attached hereto;

(c) As soon as possible and in any event within three calendar days after becoming aware of
the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible
Officer setting forth details of the Event of Default, and the action which Borrowers have taken or
proposes to take with respect thereto.

Borrower may deliver to Bank on an electronic basis any certificates, reports or information
required pursuant to this Section 6.2, and Bank shall be entitled to rely on the information
contained in the electronic files, provided that Bank in good faith believes that the files were
delivered by a Responsible Officer. If Borrower delivers this information electronically, it shall
also deliver the Compliance Certificate, in substantially the form of Exhibit D attached hereto,
bearing the physical signature of the Responsible Officer to Bank by U.S. Mail, reputable overnight
courier service, hand delivery, facsimile or .pdf file within five Business Days of submission of
the unsigned electronic copy.

 

6

 

6.3 Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely payment or
deposit of all material federal, state, and local taxes, assessments, or contributions required of
it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A., F.U.T.A.
and state disability, and will execute and deliver to Bank, on demand, proof satisfactory to Bank
indicating that Borrower or a Subsidiary has made such payments or deposits and any appropriate
certificates attesting to the payment or deposit thereof; provided that Borrower or a Subsidiary
need not make any payment if the amount or validity of such payment is contested in good faith by
appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower.

6.4 Insurance. Borrower shall maintain liability and other insurance in amounts and of a type
that are customary to businesses similar to Borrower’s. All such policies of insurance shall be in
such form, with such companies, and in such amounts as reasonably satisfactory to Bank.

6.5 Impairment Charges. Measured on a consolidated basis as reported in Borrower’s Form 10K,
impairment charges relating to Partner Companies on a cumulative basis during the term of this
Agreement shall not exceed $50,000,000.

6.6 Depository Balances. At all times, Borrowers collectively shall maintain in unrestricted
deposit accounts maintained by Bank (including without limitation deposit account #1892-76681-5),
or in certificates of deposit issued by Bank, or in securities accounts maintained with Comerica
Securities, Inc. under securities account control agreements acceptable to Bank, a balance (the
“Required Cash Balance”) of cash and Cash Equivalents that is at least equal to 100% of the balance
of the outstanding Advances, outstanding Letters of Credit, and outstanding obligations that are
subject to, or covered by, any Partner Company Guaranties (collectively, the “Guaranteed
Obligations”), provided that for the purpose of calculating the Required Cash Balance, the amount
of the Guaranteed Obligations shall be the amounts actually outstanding, and not the commitment
amount under the loan agreement or other document or instrument under which such Guaranteed
Obligations are incurred. Borrowers shall maintain their principal depository accounts with Bank.
Each Borrower authorizes Bank to decline to honor any checks, drafts or other items of payment or
directions to wire or otherwise transfer funds from Bank (and agrees that any securities accounts
maintained in connection with this Section 6.6 will be subject to Bank’s right to direct the
securities intermediary not to honor payment or transfer instructions) if and to the extent that,
after giving effect to the payment of any such item or transfer of such funds or assets, Borrowers
would not (in Bank’s sole discretion) be in compliance with this Section 6.6. Borrowers
acknowledge that Bank may, similarly, decline to make any Credit Extensions in respect of any
facilities covered by a Partner Company Guaranty if, after giving effect to such Credit Extension,
Borrowers would not be in compliance with this Section 6.6.

6.7 Further Assurances. At any time and from time to time Borrower shall execute and deliver
such further instruments and take such further action as may reasonably be requested by Bank to
effect the purposes of this Agreement.

7. NEGATIVE COVENANTS.

Each Borrower covenants and agrees that, so long as any credit hereunder shall be available
and until the outstanding Obligations are paid in full or for so long as Bank may have any
commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s
prior written consent:

7.1 Dispositions. Convey, sell, lease, transfer or otherwise dispose of (collectively, a
“Transfer”) all or any part of its business or property, other than Transfers of securities,
including debt and equity securities and partnership interests, in the ordinary course of
Borrowers’ businesses.

7.2 Change in Name, Location, Executive Office, or Executive Management; Change in Business;
Change in Fiscal Year; Change in Control. Change its name or the Borrower State or relocate its
chief executive office without 30 days prior written notification to Bank; replace its chief
executive officer or chief financial officer without providing written notification to Bank within
24 hours of such replacement; engage in any business, or permit any of its Subsidiaries to engage
in any business, other than or reasonably related or incidental to the businesses currently engaged
in by Borrower; change its fiscal year end; have a Change in Control.

 

7

 

7.3 Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge
or consolidate, with or into any other business organization (other than mergers or consolidations
of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any of its
Subsidiaries to acquire, all or substantially all of the capital stock or property of another
Person other than Partner Companies. Notwithstanding the foregoing, this Section 7.3 shall not
apply to (i) transactions in which all outstanding Obligations are satisfied in full concurrent
with the closing of that transaction, and any commitment by Bank to make any additional Credit
Extensions is terminated, or (ii) acquisitions or dispositions of Partner Companies (or interests
therein) made in the ordinary course of Borrowers’ businesses, regardless of the form of such
transactions.

7.4 Indebtedness. Create, incur, assume, guarantee or be or remain liable with respect to any
Indebtedness, or permit any Subsidiary (other than a Partner Company) so to do, other than
Permitted Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an
obligation to prepay any Indebtedness, except Indebtedness to Bank.

7.5 Encumbrances. Create, incur, assume or allow any Lien with respect to any of its
property, or assign or otherwise convey any right to receive income, except for Permitted Liens, or
covenant to any other Person that Borrower in the future will refrain from creating, incurring,
assuming or allowing any Lien with respect to any of Borrower’s property.

7.6 Distributions. Pay any dividends or make any other distribution or payment on account of
or in redemption, retirement or purchase of any capital stock, membership unit or partnership
interests, except that Borrower may make distributions in accordance with its Charter Documents in
the ordinary course of Borrower’s business as long as an Event of Default does not exist prior to
such distributions or would not exist after giving effect to such distributions.

7.7 Transactions with Affiliates. Directly or indirectly enter into or permit to exist any
material transaction with any Affiliate of Borrower except for transactions that are in the
ordinary course of Borrower’s business or as disclosed in Guarantor’s Annual Report on Form 10-K
and related proxy statement, upon fair and reasonable terms that are no less favorable to Borrower
than would be obtained in an arm’s length transaction with a non-affiliated Person.

7.8 Subordinated Debt. Make any payment in respect of any Subordinated Debt if an Event of
Default exists at the time of such proposed payment or would exist after giving effect thereto
provided that Guarantor may use the proceeds of the Debentures to repay pre-existing debt
obligations as set forth in the Offering Memorandum dated February 11, 2004 relating to the
Debentures, whether through repurchase, retirement, or one or more privately negotiated
transactions.

7.9 No Investment Company; Margin Regulation. Become or be controlled by an “investment
company,” within the meaning of the Investment Company Act of 1940, or become principally engaged
in, or undertake as one of its important activities, the business of extending credit for the
purpose of purchasing or carrying margin stock, or use the proceeds of any Credit Extension for
such purpose.

8. EVENTS OF DEFAULT.

Any one or more of the following events shall constitute an Event of Default by Borrower under
this Agreement:

8.1 Payment Default. If a Borrower fails to pay, within five Business Days of the date due,
any of the non-principal or non-interest Obligations hereunder, or fails to pay, when due, any of
the principal or interest Obligations hereunder;

 

8

 

8.2 Covenant Default.

(a) If a Borrower fails to perform any obligation under Article 6 or violates any of the
covenants contained in Article 7 of this Agreement; or fails or neglects to perform, keep, or
observe any other term, provision, condition, covenant, or agreement contained in this Agreement, in any of the
Loan Documents, or in any other present or future agreement between a Borrower and Bank and as to
any default under such other term, provision, condition, covenant or agreement that can be cured,
has failed to cure such default within 20 days after Borrower receives notice thereof or any
officer of Borrower becomes aware thereof;

8.3 Borrower Composition. If a Borrower is dissolved or any action is taken to effect such
dissolution, or if a Change in Control occurs, or if a Borrower’s or Guarantor’s existence is
otherwise terminated or any action is taken to effect such termination.

8.4 Material Adverse Change. If Bank determines that a Material Adverse Effect has occurred;

8.5 Attachment. If any portion of a Borrower’s assets is attached, seized, subjected to a
writ or distress warrant, or is levied upon, or comes into the possession of any trustee, receiver
or person acting in a similar capacity and such attachment, seizure, writ or distress warrant or
levy has not been removed, stayed, discharged or rescinded within 10 days, or if a Borrower is
enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any
material part of its business affairs, or if a judgment or other claim becomes a lien or
encumbrance upon any material portion of a Borrower’s assets, or if a notice of lien, levy, or
assessment is filed of record with respect to any of a Borrower’s assets by the United States
Government, or any department, agency, or instrumentality thereof, or by any state, county,
municipal, or governmental agency, and the same is not paid within 10 days after a Borrower
receives notice thereof, provided that none of the foregoing shall constitute an Event of Default
where such action or event is stayed or an adequate bond has been posted pending a good faith
contest by a Borrower (provided that no Credit Extensions will be required to be made during such
cure period);

8.6 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by
Borrower, or if an Insolvency Proceeding is commenced against Borrower and is not dismissed or
stayed within 30 days (provided that no Credit Extensions will be made prior to the dismissal of
such Insolvency Proceeding);

8.7 Other Agreements. If there is (i) a default or failure by Borrower to perform any
obligation in any agreement to which a Borrower (after the expiration of any grace or cure period
applicable thereto) is a party with a third party or parties resulting in a right by such third
party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an
amount in excess of $2,000,000 or that is reasonably likely to have a Material Adverse Effect, (ii)
an Event of Default or an “event of default” or a “designated event” occurs under the Debentures,
or (iii) if Borrowers fail to notify Bank of any default or failure by Guarantor to perform any
material obligation under the Debentures;

8.8 Subordinated Debt. If Borrower makes any payment on account of Subordinated Debt, except
to the extent the payment is allowed under any subordination agreement entered into with Bank;

8.9 Judgments. If a judgment or judgments for the payment of money in an amount, individually
or in the aggregate, of at least $3,000,000 shall be rendered against a Borrower and shall remain
unsatisfied and unstayed for a period of 10 days (provided that no Credit Extensions will be made
prior to the satisfaction or stay of such judgment);

8.10 Misrepresentations. If any material misrepresentation or material misstatement exists
now or hereafter in any warranty or representation set forth herein or in any certificate delivered
to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this
Agreement or any other Loan Document; or

8.11 Guaranty. If the Guaranty ceases for any reason to be in full force and effect, or the
Guarantor fails to perform any obligation under the Guaranty, or any misrepresentation or material
misstatement exists now or hereafter in any warranty or representation set forth in the Guaranty or
in any certificate delivered to Bank in connection with the Guaranty, or the Guarantor revokes or
purports to revoke its obligations under the Guaranty, or if any of the circumstances or events described in any of Sections 8.3 through
8.10 occurs with respect to the Guarantor or its property.

 

9

 

9. BANK’S RIGHTS AND REMEDIES.

9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event of
Default, Bank may, at its election, without notice of its election and without demand, do any one
or more of the following, all of which are authorized by Borrower:

(a) Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan
Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event
of Default described in Section 8.5 (insolvency), all Obligations shall become immediately due and
payable without any action by Bank);

(b) Cease advancing money or extending credit to or for the benefit of Borrower under this
Agreement or under any other agreement between Borrower and Bank;

(c) Decline to honor any checks, drafts or other items of payment or directions to wire or
otherwise transfer funds from Bank or Bank’s Affiliate, or any request by Borrower or any other
Person to pay or otherwise transfer any part of any balances maintained at Bank or Bank’s
Affiliate; and

(d) Set off and apply to the Obligations any and all (i) balances and deposits of Borrower
held by Bank, and (ii) indebtedness at any time owing to or for the credit or the account of
Borrower held by Bank.

9.2 Right of Setoff; Deposit Accounts. Upon and after the occurrence of any Event of Default,
Bank is hereby authorized by each Borrower, at any time and from time to time, (a) to set off
against, and to appropriate and apply to the payment of, the obligations and liabilities of a
Borrower under the Loan Documents (whether matured or unmatured, fixed or contingent or liquidated
or unliquidated) any and all amounts owing by Bank to a Borrower (whether payable in U.S. Dollars
or any other currency, whether matured or unmatured, and, in the case of deposits, whether general
or special, time or demand and however evidenced) and (b) pending any such action, to the extent
necessary, to hold such amounts as collateral to secure such obligations and liabilities and to
return as unpaid for insufficient funds any and all checks and other items drawn against any
deposits so held as Bank in its sole discretion may elect.

9.3 Power of Attorney. Effective only upon the occurrence and during the continuance of an
Event of Default, each Borrower hereby irrevocably appoints Bank (and any of Bank’s designated
officers, or employees) as Borrower’s true and lawful attorney to: (a) endorse Borrower’s name on
any checks or other forms of payment or security that may come into Bank’s. The appointment of Bank
as each Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being
coupled with an interest, is irrevocable until all of the Obligations have been fully repaid and
performed and Bank’s obligation to provide advances hereunder is terminated.

9.4 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents,
and all other agreements shall be cumulative. Bank shall have all other rights and remedies not
inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one
right or remedy shall be deemed an election, and no waiver by Bank of any Event of Default on a
Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver,
election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written
document signed on behalf of Bank and then shall be effective only in the specific instance and for
the specific purpose for which it was given. Each Borrower expressly agrees that this Section 9.4
may not be waived or modified by Bank by course of performance, conduct, estoppel or otherwise.

9.5 Demand; Protest. Each Borrower waives demand, protest, notice of protest, notice of
default or dishonor, notice of payment and nonpayment at maturity or otherwise, any other notices
relating to the Obligations, release, compromise, settlement, extension, or renewal of accounts, documents,
instruments, chattel paper, and guarantees at any time held by Bank on which a Borrower may in any
way be liable.

 

10

 

10. NOTICES.

Unless otherwise provided in this Agreement, all notices or demands by any party relating to
this Agreement or any other agreement entered into in connection herewith shall be in writing and
(except for financial statements and other informational documents which may be sent by first-class
mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery
service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower
or to Bank, as the case may be, at its addresses set forth below:

	 	 	 
	If to Borrower:

	 	c/o Safeguard Delaware, Inc.

1105 N. Market St., Suite 1300

Wilmington, DE 19801

Attn: Chief Financial Officer

FAX: (302) 427 — 4607
	 
	 	 
	 

	 	with a copy to:
	 
	 	 
	 

	 	Safeguard Scientifics, Inc.

435 Devon Park Drive, Building 800

Wayne, PA 19087

Attn: Brian J. Sisko

Senior Vice President and General Counsel

Fax: (610) 482-9105
	 
	 	 
	If to Bank:

	 	Comerica Bank

75 E Trimble Road

Mail Code 4770

San Jose, CA 95131

Attn: Manager

Fax: (408) 556-5091
	 
	 	 
	with a copy to:

	 	Comerica Bank

1000 Winter Street, Suite 3600

Waltham, MA 02451

Attn: Jonathan Gray

Fax: 781-487-5178

The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other.

11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

This Agreement shall be governed by, and construed in accordance with, the internal laws of the
State of California, without regard to principles of conflicts of law. Jurisdiction shall lie in
the State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED
BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF
ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES,
WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS
AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES.

 

11

 

12. REFERENCE PROVISION.

12.1 In the event the Jury Trial Waiver set forth above is not enforceable, the parties elect
to proceed under this Judicial Reference Provision.

12.2 With the exception of the items specified in clause 12.3, below, any controversy, dispute
or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any
other document, instrument or agreement between the undersigned parties (collectively in this
Section, the “Comerica Documents”), will be resolved by a reference proceeding in California in
accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure
(“CCP”), or their successor sections, which shall constitute the exclusive remedy for the
resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except
as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the
state or federal court in the county or district where the real property involved in the action, if
any, is located or in the state or federal court in the county or district where venue is otherwise
appropriate under applicable law (the “Court”).

12.3 The matters that shall not be subject to a reference are the following: (i) nonjudicial
foreclosure of any security interests in real or personal property, (ii) exercise of self-help
remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv)
temporary, provisional or ancillary remedies (including, without limitation, writs of attachment,
writs of possession, temporary restraining orders or preliminary injunctions). This reference
provision does not limit the right of any party to exercise or oppose any of the rights and
remedies described in clauses (i) and (ii) or to seek or oppose from a court of competent
jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition
to, any of those items does not waive the right of any party to a reference pursuant to this
reference provision as provided herein.

12.4 The referee shall be a retired judge or justice selected by mutual written agreement of
the parties. If the parties do not agree within 10 days of a written request to do so by any party,
then, upon request of any party, the referee shall be selected by the Presiding Judge of the Court
(or his or her representative). A request for appointment of a referee may be heard on an ex parte
or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is
not granted. Pursuant to CCP § 170.6, each party shall have one peremptory challenge to the
referee selected by the Presiding Judge of the Court (or his or her representative).

12.5 The parties agree that time is of the essence in conducting the reference proceedings.
Accordingly, the referee shall be requested, subject to change in the time periods specified herein
for good cause shown, to (i) set the matter for a status and trial-setting conference within 15
days after the date of selection of the referee, (ii) if practicable, try all issues of law or fact
within 120 days after the date of the conference and (iii) report a statement of decision within 20
days after the matter has been submitted for decision.

12.6 The referee will have power to expand or limit the amount and duration of discovery. The
referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s
failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based
upon good cause shown, no party shall be entitled to “priority” in conducting discovery,
depositions may be taken by either party upon seven days written notice, and all other discovery
shall be responded to within 15 days after service. All disputes relating to discovery which cannot
be resolved by the parties shall be submitted to the referee whose decision shall be final and
binding.

12.7 Except as expressly set forth herein, the referee shall determine the manner in which the
reference proceeding is conducted including the time and place of hearings, the order of
presentation of evidence, and all other questions that arise with respect to the course of the
reference proceeding. All proceedings and hearings conducted before the referee, except for trial,
shall be conducted without a court reporter, except that when any party so requests, a court
reporter will be used at any hearing conducted before the referee, and the referee will be provided
a courtesy copy of the transcript. The party making such a request shall have the obligation to
arrange for and pay the court reporter. Subject to the referee’s power to award costs to the
prevailing party, the parties will equally share the cost of the referee and the court reporter at
trial.

 

12

 

12.8 The referee shall be required to determine all issues in accordance with existing case
law and the statutory laws of the State of California. The rules of evidence applicable to
proceedings at law in the State of California will be applicable to the reference proceeding. The referee shall be empowered
to enter equitable as well as legal relief, enter equitable orders that will be binding on the
parties and rule on any motion which would be authorized in a court proceeding, including without
limitation motions for summary judgment or summary adjudication. The referee shall issue a decision
at the close of the reference proceeding which disposes of all claims of the parties that are the
subject of the reference. Pursuant to CCP § 644, such decision shall be entered by the Court as a
judgment or an order in the same manner as if the action had been tried by the Court and any such
decision will be final, binding and conclusive. The parties reserve the right to appeal from the
final judgment or order or from any appealable decision or order entered by the referee. The
parties reserve the right to findings of fact, conclusions of laws, a written statement of
decision, and the right to move for a new trial or a different judgment, which new trial, if
granted, is also to be a reference proceeding under this provision.

12.9 If the enabling legislation which provides for appointment of a referee is repealed (and
no successor statute is enacted), any dispute between the parties that would otherwise be
determined by reference procedure will be resolved and determined by arbitration. The arbitration
will be conducted by a retired judge or justice, in accordance with the California Arbitration Act
§1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to
discovery set forth above shall apply to any such arbitration proceeding.

12.10 THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED
UNDER THIS REFERENCE PROVISION WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY
KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE
PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR
IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS.

13. CO-BORROWER PROVISIONS.

(a) Primary Obligation. This Agreement is a primary and original obligation of each Borrower
and shall remain in effect notwithstanding future changes in conditions, including any change of
law or any invalidity or irregularity in the creation or acquisition of any Obligations or in the
execution or delivery of any agreement between Bank and any Borrower. Each Borrower shall be
liable for existing and future Obligations as fully as if all Credit Extensions were advanced to
such Borrower. Bank may rely on any certificate or representation made by any Borrower as made on
behalf of, and binding on, all Borrowers, including without limitation Disbursement Request Forms
and Compliance Certificates.

(b) Enforcement of Rights. Borrowers are jointly and severally liable for the Obligations and
Bank may proceed against one or more of the Borrowers to enforce the Obligations without waiving
its right to proceed against any of the other Borrowers.

(c) Borrowers as Agents. Each Borrower appoints the other Borrower as its agent with all
necessary power and authority to give and receive notices, certificates or demands for and on
behalf of both Borrowers, to act as disbursing agent for receipt of any Credit Extensions on behalf
of each Borrower and to apply to Bank on behalf of each Borrower for Credit Extensions, any waivers
and any consents. This authorization cannot be revoked, and Bank need not inquire as to each
Borrower’s authority to act for or on behalf of Borrower.

(d) Subrogation and Similar Rights. Notwithstanding any other provision of this Agreement or
any other Loan Document, each Borrower irrevocably waives all rights that it may have at law or in
equity (including, without limitation, any law subrogating the Borrower to the rights of Bank under
the Loan Documents) to seek contribution, indemnification, or any other form of reimbursement from
any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any of
the Obligations, for any payment made by the Borrower with respect to the Obligations in connection
with the Loan Documents or otherwise and all rights that it might have to benefit from, or to
participate in, any security for the Obligations as a result of any payment made by the Borrower
with respect to the Obligations in connection with the Loan Documents or otherwise. Any agreement
providing for indemnification, reimbursement or any other arrangement prohibited under this Section
13 shall be null and void. If any payment is made to a Borrower in contravention of this Section
13, such Borrower shall hold such payment in trust for Bank and such payment shall be promptly delivered to Bank for application
to the Obligations, whether matured or unmatured.

 

13

 

(e) Waivers of Notice. Except as otherwise provided in this Agreement, each Borrower waives
notice of acceptance hereof; notice of the existence, creation or acquisition of any of the
Obligations; notice of an Event of Default; notice of the amount of the Obligations outstanding at
any time; notice of intent to accelerate; notice of acceleration; notice of any adverse change in
the financial condition of any other Borrower or of any other fact that might increase the
Borrower’s risk; presentment for payment; demand; protest and notice thereof as to any instrument;
default; and all other notices and demands to which the Borrower would otherwise be entitled. Each
Borrower waives any defense arising from any defense of any other Borrower, or by reason of the
cessation from any cause whatsoever of the liability of any other Borrower. Bank’s failure at any
time to require strict performance by any Borrower of any provision of the Loan Documents shall not
waive, alter or diminish any right of Bank thereafter to demand strict compliance and performance
therewith. Nothing contained herein shall prevent Bank from foreclosing on the Lien of any deed of
trust, mortgage or other security instrument, or exercising any rights available thereunder, and
the exercise of any such rights shall not constitute a legal or equitable discharge of any
Borrower. Each Borrower also waives any defense arising from any act or omission of Bank that
changes the scope of the Borrower’s risks hereunder.

(f) Subrogation Defenses. Each Borrower hereby waives any defense based on impairment or
destruction of its subrogation or other rights against any other Borrower and waives all benefits
which might otherwise be available to it under California Civil Code Sections 2809, 2810, 2819,
2839, 2845, 2848, 2849, 2850, 2899, and 3433 and California Code of Civil Procedure Sections 580a,
580b, 580d and 726, as those statutory provisions are now in effect and hereafter amended, and
under any other similar statutes now and hereafter in effect.

(g) Right to Settle, Release.

The liability of Borrowers hereunder shall not be diminished by (i) any agreement,
understanding or representation that any of the Obligations is or was to be guaranteed by another
Person or secured by other property, or (ii) any release or unenforceability, whether partial or
total, of rights, if any, which Bank may now or hereafter have against any other Person, including
another Borrower, or property with respect to any of the Obligations.

Without affecting the liability of any Borrower hereunder, Bank may (i) compromise, settle,
renew, extend the time for payment, change the manner or terms of payment, discharge the
performance of, decline to enforce, or release all or any of the Obligations with respect to a
Borrower, (ii) grant other indulgences to a Borrower in respect of the Obligations, (iii) modify in
any manner any documents relating to the Obligations with respect to a Borrower, (iv) release,
surrender or exchange any deposits or other property securing the Obligations, whether pledged by a
Borrower or any other Person, or (v) compromise, settle, renew, or extend the time for payment,
discharge the performance of, decline to enforce, or release all or any obligations of any
guarantor, endorser or other Person who is now or may hereafter be liable with respect to any of
the Obligations.

(h) Subordination. All indebtedness of a Borrower now or hereafter arising held by another
Borrower is subordinated to the Obligations and the Borrower holding the indebtedness shall take
all actions reasonably requested by Lender to effect, to enforce and to give notice of such
subordination.

14. GENERAL PROVISIONS.

14.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of the
respective successors and permitted assigns of each of the parties and shall bind all persons who
become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any
rights hereunder may be assigned by Borrower without Bank’s prior written consent, which consent
may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the
consent of or notice to Borrower to sell, transfer, negotiate, or grant participation in all or any
part of, or any interest in, Bank’s obligations, rights and benefits hereunder.

 

14

 

14.2 Indemnification. Borrower shall defend, indemnify and hold harmless Bank and its
officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities
claimed or asserted by any other party in connection with the transactions contemplated by this
Agreement; and (b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its
officers, employees and agents as a result of or in any way arising out of, following, or
consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise
(including without limitation reasonable attorneys fees and expenses), except for losses caused by
Bank’s gross negligence or willful misconduct.

14.3 Time of Essence. Time is of the essence for the performance of all obligations set forth
in this Agreement.

14.4 Severability of Provisions. Each provision of this Agreement shall be severable from
every other provision of this Agreement for the purpose of determining the legal enforceability of
any specific provision.

14.5 Amendments in Writing, Integration. All amendments to or terminations of this Agreement
or the other Loan Documents must be in writing. All prior agreements, understandings,
representations, warranties, and negotiations between the parties hereto with respect to the
subject matter of this Agreement and the other Loan Documents, if any, are merged into this
Agreement and the Loan Documents.

14.6 Effect of Amendment and Restatement. This Agreement is intended to and does completely
amend and restate, without novation, the Original Agreement. All security interests granted under
the Original Agreement are hereby confirmed and ratified and shall continue to secure all
Obligations under this Agreement.

14.7 Counterparts. This Agreement may be executed in any number of counterparts and by
different parties on separate counterparts, each of which, when executed and delivered, shall be
deemed to be an original, and all of which, when taken together, shall constitute but one and the
same Agreement.

14.8 Survival. All covenants, representations and warranties made in this Agreement shall
continue in full force and effect so long as any Obligations remain outstanding or Bank has any
obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank
with respect to the expenses, damages, losses, costs and liabilities described in Section 13.2
shall survive until all applicable statute of limitations periods with respect to actions that may
be brought against Bank have run.

14.9 Confidentiality. In handling any confidential information, Bank and all employees and
agents of Bank shall exercise the same degree of care that Bank exercises with respect to its own
proprietary information of the same types to maintain the confidentiality of any non-public
information thereby received or received pursuant to this Agreement except that disclosure of such
information may be made (i) to the subsidiaries or Affiliates of Bank in connection with their
present or prospective business relations with Borrower, (ii) to prospective transferees or
purchasers of any interest in the Loans, provided that they have entered into a comparable
confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as
required by law, regulations, rule or order, subpoena, judicial order or similar order, (iv) as may
be required in connection with the examination, audit or similar investigation of Bank and (v) as
Bank may determine in connection with the enforcement of any remedies hereunder. Confidential
information hereunder shall not include information that either: (a) is in the public domain or in
the knowledge or possession of Bank when disclosed to Bank, or becomes part of the public domain
after disclosure to Bank through no fault of Bank; or (b) is disclosed to Bank by a third party,
provided Bank does not have actual knowledge that such third party is prohibited from disclosing
such information.

 

15

 

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written.

	 	 	 	 	 
	 	 	SAFEGUARD DELAWARE, INC.
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Jeffrey B. McGroarty
	 

	 	 	 	 
	 

	 	Title:
	 	Vice President
	 

	 	 	 	 
	 
	 	 	 	 
	 	 	SAFEGUARD SCIENTIFICS

(DELAWARE), INC.
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Jeffrey B. McGroarty
	 

	 	 	 	 
	 

	 	Title:
	 	Vice President
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	COMERICA
	 	BANK
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Jonathan Gray
	 

	 	 	 	 
	 

	 	Title:
	 	Senior Vice President
	 

	 	 	 	 

 

16

 

EXHIBIT A

DEFINITIONS

“Advance” or “Advances” means a cash advance or cash advances under the Revolving Line.

“Affiliate” means, with respect to any Person, any Person that owns or controls directly or
indirectly such Person, any Person that controls or is controlled by or is under common control
with such Person, and each of such Person’s senior executive officers, directors, and partners.

“Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and
expenses, whether generated in-house or by outside counsel) incurred in connection with the
preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable
Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses (whether generated
in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents
(including fees and expenses of appeal), incurred before, during and after an Insolvency
Proceeding, whether or not suit is brought.

“Borrower State” means Delaware, the state under whose laws each Borrower is organized.

“Borrower’s Books” means all of Borrower’s books and records including: ledgers; records
concerning Borrower’s assets or liabilities, the Collateral, business operations or financial
condition; and all computer programs, or tape files, and the equipment, containing such
information.

“Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the
State of California or the Commonwealth of Pennsylvania are authorized or required to close.

“Cash Equivalents” means (i) marketable direct obligations issued or unconditionally guaranteed by
the United States of America or any agency or any State thereof maturing within one (1) year from
the date of acquisition thereof, (ii) commercial paper maturing no more than one (I) year from the
date of creation thereof and currently having a rating of at least A-2 or P-2 from either Standard
& Poor’s Corporation or Moody’s Investors Service, (iii) certificates of deposit, time deposits or
Euro time deposits maturing no more than one (1) year from the date of investment therein, and (iv)
money market accounts.

“Change in Control” shall mean a transaction in which any “person” or “group” (within the
meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the
“beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly
or indirectly, of a sufficient number of shares of all classes of stock then outstanding of a
Borrower ordinarily entitled to vote in the election of directors, empowering such “person” or
“group” to elect a majority of the Board of Directors of such Borrower, who did not have such power
before such transaction.

“Charter Documents” means, as to each Borrower, its certificate of incorporation and bylaws.

“Chief Executive Office State” means Pennsylvania, where Guarantor’s chief executive office is
located.

“Closing Date” means the date of this Agreement.

“Code” means the California Uniform Commercial Code as amended or supplemented from time to time.

“Collateral” means the property described on Exhibit B attached hereto.

 

 

 

“Contingent Obligation” means, as applied to any Person, any direct or indirect liability,
contingent or otherwise, of that Person with respect to (i) any indebtedness, lease, dividend,
letter of credit or other obligation of another, including, without limitation, any such obligation
directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse by that
Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any
obligations with respect to undrawn letters of credit, corporate credit cards or merchant services
issued for the account of that Person; and (iii) all obligations arising under any interest rate, currency or
commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other
agreement or arrangement designated to protect a Person against fluctuation in interest rates,
currency exchange rates or commodity prices; provided, however, that the term “Contingent
Obligation” shall not include endorsements for collection or deposit in the ordinary course of
business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the
stated or determined amount of the primary obligation in respect of which such Contingent
Obligation is made or, if not stated or determinable, the maximum reasonably anticipated liability
in respect thereof as determined by such Person in good faith; provided, however, that such amount
shall not in any event exceed the maximum amount of the obligations under the guarantee or other
support arrangement.

“Credit Extension” means each Advance, Letter of Credit, Partner Company Guaranty or any other
extension of credit by Bank for the benefit of Borrowers hereunder.

“Daily Balance” means the amount of the Obligations owed at the end of a given day.

“Debentures” means those certain Convertible Senior Debentures issued by Guarantor pursuant to the
Offering Memorandum dated February 11, 2004, in substantially the form provided to Bank on February
10, 2004, up to an aggregate principal amount of $150,000,000.

“ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations
thereunder.

“Event of Default” has the meaning assigned in Article 8.

“GAAP” means generally accepted accounting principles, consistently applied, as in effect from time
to time.

“Guarantor” means Safeguard Scientifics, Inc.

“Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of
property or services, including without limitation reimbursement and other obligations with respect
to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or
similar instruments, (c) all capital lease obligations, and (d) all Contingent Obligations.

“Insolvency Proceeding” means any proceeding commenced by or against any Person or entity under any
provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or
insolvency law, including assignments for the benefit of creditors, formal or informal moratoria,
compositions, extension generally with its creditors, or proceedings seeking reorganization,
arrangement, or other relief.

“Investment” means any beneficial ownership of (including stock, partnership or limited liability
company interest or other securities) any Person, or any loan, advance or capital contribution to
any Person.

“IRC” means the Internal Revenue Code of 1986, as amended, and the regulations thereunder.

“Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other
encumbrance.

“Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and
any other document, instrument or agreement entered into in connection with this Agreement, all as
amended or extended from time to time.

“Material Adverse Effect” means a material adverse effect on (i) the business operations or
condition (financial or otherwise) of the Borrowers, taken as a whole or (ii) the ability of a
Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents.

 

 

 

“Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to Bank by
Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent, due or
to become due, now existing or hereafter arising, including any interest that accrues after the commencement of an
Insolvency Proceeding and including any debt, liability, or obligation owing from Borrower to
others that Bank may have obtained by assignment or otherwise.

“Partner Company” or “ Partner Companies” means Persons in which a Borrower or Guarantor has an
equity investment, as reported or as will be reported in Guarantor’s consolidated financial
statements from time to time.

“Partner Company Guaranty” or “Partner Company Guaranties” means one or more guaranties by Borrower
for the benefit of Bank.

“Periodic Payments” means all installments or similar recurring payments that Borrower may now or
hereafter become obligated to pay to Bank pursuant to the terms and provisions of any instrument,
or agreement now or hereafter in existence between Borrower and Bank.

“Permitted Indebtedness” means:

(a) Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan
Document;

(b) Indebtedness existing on the Closing Date and disclosed in the Schedule;

(c) Guaranties in support of Partner Companies;

(d) Indebtedness in the form of equipment leases or purchase money financing for equipment,
provided the aggregate outstanding amount of such Indebtedness does not exceed $5,000,000;

(e) unsecured Indebtedness incurred in a single transaction in an aggregate amount not to exceed
$250,000 provided the aggregate amount of all such Indebtedness shall not at any time exceed
$1,000,000;

(f) Contingent Obligations in the form of hedging agreements entered into in the ordinary course of
a Borrower’s business on terms reasonably acceptable to Bank;

(g) Subordinated Debt; and

(h) Extensions, refinancings, modifications, amendment and restatement of any item of Permitted
Indebtedness described in clauses (a) through (f) above; provided that the principal amount thereof
is not increased or the terms thereof are not modified to impose more burdensome terms upon
Borrower.

“Permitted Liens” means the following:

(a) Any Liens existing on the Closing Date and disclosed in the Schedule or arising under this
Agreement or the other Loan Documents;

(b) Liens for taxes, fees, assessments or other governmental charges or levies, either not
delinquent or being contested in good faith by appropriate proceedings;

(c) Liens (i) upon or in any equipment acquired or held by a Borrower to secure the purchase price
of such equipment or indebtedness incurred solely for the purpose of financing the acquisition of
such equipment, or (ii) existing on such equipment at the time of its acquisition, provided that
the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds
of such equipment;

(d) Liens incurred in connection with the extension, renewal or refinancing of the indebtedness
secured by Liens of the type described in clauses (a) through (c) above, provided that any
extension, renewal or replacement Lien shall be limited to the property encumbered by the existing
Lien and the principal amount of the indebtedness being extended, renewed or refinanced does not
increase; and

 

 

 

(e) Carrier’s, warehousemen’s , mechanic’s, materialmen’s, repairmen’s or other like Liens imposed
by law.

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint
venture, trust, unincorporated organization, association, corporation, institution, public benefit
corporation, firm, joint stock company, estate, entity or governmental agency.

“Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank, as
its “prime rate,” whether or not such announced rate is the lowest rate available from Bank.

“Responsible Officer” means each of the Chief Executive Officer, the Vice President, Operations,
the Chief Financial Officer and the Controller of Guarantor.

“Revolving Line” means a Credit Extension of up to $30,000,000.

“Revolving Maturity Date” means June 29, 2009.

“Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any.

“SOS Reports” means the official reports from the Secretary of State of Delaware, each Chief
Executive Office State and the Borrower State and other applicable federal, state or local
government offices identifying all current security interests filed in the Collateral and Liens of
record as of the date of such report.

“Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt
owing by Borrower to Bank on terms reasonably acceptable to Bank (and identified as being such by
Borrower and Bank).

“Subsidiary” means any corporation, partnership or limited liability company or joint venture in
which (i) any general partnership interest or (ii) more than 50% of the stock, limited liability
company interest or joint venture of which by the terms thereof ordinary voting power to elect the
Board of Directors, managers or trustees of the entity, at the time as of which any determination
is being made, is owned by Borrower, either directly or through an Affiliate.

 

 

 

	 	 	 
	DEBTOR

	 	SAFEGUARD DELAWARE, INC. and SAFEGUARD SCIENTIFICS (DELAWARE), INC.
	 
	 	 
	SECURED PARTY:

	 	COMERICA BANK

EXHIBIT B

COLLATERAL DESCRIPTION ATTACHMENT TO

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT

(a) All cash, securities, certificates of deposit, instruments, deposit accounts, money market
accounts, securities accounts, investment property, financial assets, and any other accounts or
property, now owned or hereafter acquired, either held or in possession of Bank, Comerica
Securities, Inc. and any of Bank’s Affiliates, and

(b) all proceeds and substitutions thereof, including interest and dividends payable thereon,
now or in the future held therein, all interest paid thereon, and all other cash and noncash
proceeds of the foregoing.

All terms above have the meanings given to them in the California Uniform Commercial Code, as
amended or supplemented from time to time.

 

 

 

EXHIBIT C

TECHNOLOGY & LIFE SCIENCES DIVISION

LOAN ANALYSIS

LOAN ADVANCE/PAYDOWN REQUEST FORM

DEADLINE FOR SAME DAY PROCESSING IS 3:30 P.M. Eastern Time

DEADLINE FOR WIRE TRANSFERS IS 3:30 P.M. Eastern Time

	 	 	 	 	 
	TO: Loan Analysis

	 	DATE:
	 	TIME:
	FAX #: (650) 846-6840
	 	 	 	 

	 	 	 	 	 
	FROM:

	 	SAFEGUARD DELAWARE, INC. and
	 	TELEPHONE REQUEST (For Bank Use Only):
	 

	 	SAFEGUARD SCIENTIFICS	 	 
	 

	 	(DELAWARE), INC.	 	 
	 

	 	Borrower’s Name	 	 
	FROM:

	 	 	 	The following person is authorized to request the loan payment transfer/loan advance on
the designated account and is known to me.
	 

	 	Authorized Signer’s Name	 	 
	 
	 	 	 	 
	FROM:
	 	 	 	 
	 

	 	Authorized Signature (Borrower)
	 	     Authorized Request & Phone #
	PHONE #:
	 	 	 	 
	 

	 	 	 	     Received by (Bank) & Phone #
	 
	 	 	 	 
	FROM ACCOUNT#:	 	 
	(please include Note number, if applicable)	 	 
	TO ACCOUNT #:	 	     Authorized Signature (Bank)
	(please include Note number, if applicable)	 	 

	 	 	 	 	 
	REQUESTED TRANSACTION TYPE

	 	REQUESTED DOLLAR AMOUNT
	 	     For Bank Use Only
	 
	 	 	 	 
	PRINCIPAL INCREASE* (ADVANCE)

	 	$
	 	Date Rec’d:
	PRINCIPAL PAYMENT (ONLY)

	 	$
	 	Time:
	 

	 	 	 	Comp. Status:  YES  NO
	OTHER INSTRUCTIONS:

	 	 	 	Status Date:
	 

	 	 	 	Time:
	 

	 	 	 	Approval:

All representations and warranties of Borrower stated in the Amended and Restated Loan and Security Agreement are true, correct and complete in all material respects
as of the date of the telephone request for and advance confirmed by this Borrowing Certificate, including without limitation the representation that Borrower has
paid for and owns the equipment financed by the Bank; provided, however, that those representations and warranties the date expressly referring to another date shall
be true, correct and complete in all material respects as of such date.

*IS THERE A WIRE REQUEST TIED TO THIS LOAN ADVANCE? (PLEASE CIRCLE ONE)       YES  NO

If YES, the Outgoing Wire Transfer Instructions must be completed below.

	 	 	 	 	 
	OUTGOING WIRE TRANSFER INSTRUCTIONS

	 	Fed Reference Number
	 	Bank Transfer Number

The items marked with an asterisk (*) are required to be completed.

	 	 	 
	*Beneficiary Name

	 	 
	 

	 	 
	*Beneficiary Account Number

	 	 
	 

	 	 
	*Beneficiary Address

	 	 
	 

	 	 
	Currency Type

	 	US DOLLARS ONLY
	 

	 	 
	*ABA Routing Number (9 Digits)

	 	 
	 

	 	 
	*Receiving Institution Name

	 	 
	 

	 	 
	*Receiving Institution Address

	 	 
	 

	 	 
	*Wire Account

	 	$ 
	 

	 	 

 

 

 

EXHIBIT D

COMPLIANCE CERTIFICATE

	 	 	 
	TO:

	 	COMERICA BANK
	 
	 	 
	FROM:

	 	SAFEGUARD DELAWARE, INC. and SAFEGUARD SCIENTIFICS (DELAWARE), INC.

The undersigned authorized officer of SAFEGUARD DELAWARE, INC. and SAFEGUARD SCIENTIFICS
(DELAWARE), INC. hereby certifies that in accordance with the terms and conditions of the Amended
and Restated Loan and Security Agreement between Borrower and Bank (the “Agreement”), (i) Borrower
is in complete compliance for the period ending
 _____ 
with all required covenants except
as noted below and (ii) all representations and warranties of Borrower stated in the Agreement are
true and correct as of the date hereof. Attached herewith are the required documents supporting
the above certification. The Officer further certifies that these are prepared in accordance with
Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the
next except as explained in an accompanying letter or footnotes.

Please indicate compliance status by circling Yes/No under “Complies” column.

	 	 	 	 	 	 	 
	Reporting Covenant	 	Required	 	Complies
	Guarantor:
	 	 	 	 	 	 
	10Q

	 	Quarterly, within 45 days* (excluding FYE)
	 	Yes
	 	No
	10K

	 	FYE within 90 days*
	 	Yes
	 	No
	 
	 	 	 	 	 	 
	Borrowers:
	 	 	 	 	 	 
	Quarterly consolidating financial statements

	 	Quarterly, within 45 days* (excluding FYE)
	 	Yes
	 	No
	FYE consolidating financial statements

	 	FYE within 90 days*
	 	Yes
	 	No

*or such longer period of time as may be afforded by the Securities and Exchange Commission pursuant to Rule 12b-25

	 	 	 	 	 	 	 	 	 
	Financial Covenant	 	Required	 	Actual	 	Complies
	Minimum Unrestricted Cash at Bank (continuous)

	 	See Agreement
	 	 
	 	Yes
	 	No
	Maximum private company impairment charges

	 	$50,000,000 
	 	 	 	Yes
	 	No

	 	 	 	 	 
	Comments Regarding Exceptions: See Attached.	 	BANK USE ONLY
	 
	 	 	 	 
	 

	 	Received by:	 	 
	 

	 	 	 	 
	Sincerely,

	 	 	 	AUTHORIZED SIGNER
	 
	 	 	 	 
	 

	 	Date:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	Verified:	 	 
	 

	 	 	 	 
	SIGNATURE

	 	 	 	AUTHORIZED SIGNER
	 
	 	 	 	 
	 

	 	Date:	 	 
	 

	 	 	 	 
	TITLE
	 	 	 	 
	 
	 	 	 	 
	 	 	Compliance Status                    Yes     No
	 
 

DATE

	 	   	 	 

 

 

 

SCHEDULE OF EXCEPTIONS

Permitted Indebtedness (Exhibit A)

None.

Permitted Liens (Exhibit A)

None.

Prior Names (Section 5.5)

None.

Litigation (Section 5.6)

None.

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