Document:

Employment Transition Agreement

 Exhibit 10.43 
 EMPLOYMENT TRANSITION AGREEMENT 
 This Employment
Transition Agreement (this “Agreement”) is entered into between Henry Pan, an individual (“Executive”), and Prometheus Laboratories Inc. (the “Company”), effective as of January 4, 2010 (the “Effective
Date”). 
 WHEREAS, the Company desires to retain Executive to provide services to the Company and wishes to provide
Executive with certain compensation and benefits in return for Executive’s services; and 
 WHEREAS, Executive wishes to
provide services to the Company in return for certain compensation and benefits. 
 NOW, THEREFORE, in consideration of the
mutual promises herein contained, the parties agree as follows: 
 1. Definitions. As used in this Agreement, the
following terms shall have the following meanings: 
 (a) Board. “Board” means the board of directors of the
Company. 
 (b) Stock Awards. “Stock Awards” means all stock options, stock appreciation rights, restricted
stock and such other awards granted pursuant to the Company’s stock option and equity incentive award plans or agreements and any shares of stock issued upon exercise thereof. 
 2. Termination of Employment/Consulting Services. 
 (a) Termination of Employment. Executive’s employment with the Company shall terminate as of the Effective Date, including his position as Executive Vice President and Chief Medical Officer
(and any other titles or officer positions he may hold) of the Company (and any of its affiliates and subsidiaries). 
 (b)
Consulting Period. Following the Effective Date, Executive shall continue to provide services to the Company through September 30, 2010 (the “Consulting Period”). There shall be no break in service as a result of
Executive’s conversion from an employee to an independent contractor for purposes of Executive’s Stock Awards. Executive’s consulting services pursuant to this Agreement shall terminate automatically on September 30, 2010, unless
extended in writing by Company and Executive. 
 (c) Status as Consultant. During the Consulting Period, Executive
acknowledges that Executive shall be an independent contractor of the Company and not an employee. Subject to the Company’s payment obligations under Section 5(c) below, the Company shall be entitled to terminate the Consulting Period on
ninety (90) days’ prior written notice to Executive and Executive shall be entitled to terminate the Consulting Period on ninety (90) days’ prior written notice to the Company, which Company or Executive notice may not be given
prior to June 30, 2010. 

 3. Duties and Services. 
 (a) During the Consulting Period, Executive shall devote such percentage of his business time and effort to the performance of his services
hereunder as may be mutually agreed upon by the Chief Executive Officer of the Company and Executive. Executive shall, upon the request or direction of the Board or the Chief Executive Officer of the Company, provide such additional information,
advice and assistance concerning matters that are within the scope of Executive’s knowledge and expertise. During the Consulting Period, Executive shall also assist the Company’s Chief Executive Officer with transition matters. During the
Consulting Period, Executive shall continue to be provided with office space, voicemail access, email access and such other support as the Company may determine in good faith is necessary for Executive’s satisfactory performance of his services
hereunder. 
 (b) If requested by the Board or the Chief Executive Officer of the Company, Executive shall provide the services
in person at the principal executive offices of Company or at another location to be mutually agreed by Executive and the Chief Executive Officer of the Company. The Company shall reasonably accommodate Executive’s schedule when requesting
Executive’s assistance pursuant to this Section 3(b). During the Consulting Period, Executive shall have no power or authority to enter into contracts on behalf of Company or to bind Company in any way, and Executive shall not create
obligations on the part of Company or represent to any party that he has such power or authority. 
 4. Compensation During
Consulting Period. 
 (a) Consulting Period. During the Consulting Period, Executive shall be entitled to receive the
following compensation and benefits from the Company: 
 (i) The Company shall pay Executive a retainer of $22,200 per month,
payable on the first day of each calendar month during the Consulting Period. 
 (ii) Executive acknowledges that, following
the Effective Date, Executive shall not be eligible to participate in any plan or program which, as a condition of eligibility for such plan or program, requires Executive to be an employee of the Company. 
 (b) Expenses. The Company shall reimburse Executive for reasonable out-of-pocket business expenses incurred in
connection with the performance of his services hereunder, subject to (i) such policies as the Company may from time to time establish, and (ii) Executive furnishing the Company with evidence in the form of receipts satisfactory to the
Company substantiating the claimed expenditures. This will include expenses incurred for monthly telephone and PDA charges, to a limit of $120.00 per month. Additional reimbursement for telephone and PDA charges exceeding this limit may be made at
the discretion of the Company. 
  

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 (c) Stock Awards. During the Consulting Period, and in addition to any accelerated
vesting pursuant to Section 5(c) below, all of Executive’s unexercised Stock Awards shall continue to vest and be exercisable, if applicable, pursuant to the terms of the Company equity plan(s) and stock award agreements pursuant to which
they were granted. Following the termination of the Consulting Period, the vested Stock Awards shall be exercisable by Executive in accordance with the terms of the Company equity plan(s) and stock award agreements pursuant to which they were
granted. 
 5. Termination and Severance. 
 (a) Exclusive Termination Benefits. On the Effective Date, Executive shall be entitled to receive the benefits set forth in this Section 5. If Executive’s employment or service under this
Agreement terminates for any reason, Executive shall not be entitled to any payments, benefits, damages, awards or compensation other than as provided in this Agreement. 
 (b) Payments Upon Termination of Employment. On the Effective Date, Executive (or in the event of Executive’s death, Executive’s estate or designated beneficiary) shall be entitled to
receive, in lieu of any severance benefits to which Executive may otherwise be entitled under any severance plan or program of the Company, the benefits provided below: 
 (i) The Company shall pay to Executive his fully earned but unpaid base salary, when due, through the Effective Date at the rate then in effect, plus all other amounts or benefits to which Executive is
entitled under any compensation, retirement or benefit plan or practice of the Company as of the Effective Date in accordance with the terms of such plans or practices. Subject to Sections 5(b)(ii) through (iv) and Section 5(c) below,
Executive acknowledges and agrees that with his final check, the payment of any outstanding expense reimbursements, and the payment of any amounts payable under any of the employee benefit plans of the Company in accordance with the terms of such
plans, Executive will have received all monies, bonuses, commissions, expense reimbursement, vacation pay, or other compensation he earned or was due during his employment by the Company. 
 (ii) Subject to Section 5(e) and Executive’s continued compliance with Section 6, Executive shall be entitled to receive
severance pay in an amount equal to Executive’s annual base salary as in effect immediately prior to the date of termination of the Employment Period, payable as follows: (A) Executive shall be paid $15,369.23 bi-weekly through the
Company’s regularly scheduled payroll commencing on January 4, 2010 and continuing through March 31, 2010, and (B) an amount equal to $99,900.00 less the total of all payments to Executive pursuant to the preceding clause
(A) shall be paid to Executive on March 31, 2010. 
 (iii) Subject to Section 5(e) and Executive’s
continued compliance with Section 6, for the period beginning on the Effective Date and ending on July 31, 2010, the Company shall make co-payments for the costs associated with continuation coverage pursuant to the Consolidated Omnibus
Budget Reconciliation Act of 1985, as amended (“COBRA”) for Executive and his eligible dependents who were covered under the Company’s health plans as of the date of Executive’s termination such that Executive’s premiums are
the same as for active employees (provided that Executive shall be solely responsible for all matters relating to his continuation of coverage pursuant to COBRA, including, without limitation, his election of such coverage). 
  

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 (iv) Subject to Section 5(e) and Executive’s continued compliance with
Section 6, Executive shall receive remuneration in consideration of a management bonus for the 2009 calendar year, in the amount of $159,840.00. This will be paid on or before January 31, 2010 and will be subject to applicable taxes and
withholdings. 
 (c) Termination of Consulting Period. If Executive’s service to the Company during the Consulting
Period is terminated for any reason, including as a result of the expiration of the Consulting Period and the non-renewal of this Agreement or Executive’s death, the Company shall not have any other or further obligations to Executive under
this Agreement (including any financial obligations) except that Executive (or, in the event of Executive’s death, his estate or designated beneficiary) shall be entitled to receive (i) all amounts due and payable under Section 4
above up to and including the date of termination, (ii) all unpaid amounts under Section 5(b)(ii) and 5(b)(iv) and the continued provision of benefits under Section 5(b)(iii) as provided therein, (iii) all other amounts or
benefits to which Executive is entitled under any compensation, retirement or benefit plan or practice of the Company at the time of termination in accordance with the terms of such plans or practices, and (iv) the vesting and/or exercisability
of such number of Executive’s outstanding unvested Stock Awards as would have vested during the remainder of the Consulting Period, if any, shall be automatically accelerated on the date of termination. All vesting of Executive’s remaining
unvested Stock Awards previously granted to him by the Company shall cease and none of such unvested Stock Awards shall be exercisable following the date of such termination. The foregoing shall be in addition to, and not in lieu of, any and all
other rights and remedies which may be available to the Company under the circumstances, whether at law or in equity. 
 (d)
Exclusive Remedy. Except as otherwise expressly required by law (e.g., COBRA) or as specifically provided herein, all of Executive’s rights to severance, benefits, and other amounts hereunder (if any) accruing after the termination of
Executive’s employment by or service to the Company shall cease upon such termination. In the event of a termination of Executive’s employment by or service to the Company under this Agreement, Executive’s sole remedy shall be to
receive the payments and benefits described in this Section 5. 
 (e) Release. As a condition to Executive’s
receipt of any post-termination benefits pursuant to Sections 5(b)(ii), (iii) and (iv) above, Executive shall execute and not revoke a general release of all claims in favor of the Company (the “Release”) in substantially the
form attached hereto as Exhibit A. In the event Executive does not sign or revokes the Release within the sixty (60) day period following the Effective Date, Executive shall not be entitled to the aforesaid payments and benefits. The
date on which Executive’s Release becomes effective and non-revocable is referred to herein as the “Release Effective Date.” 
 (f) No Mitigation. Executive shall not be required to mitigate the amount of any payment provided for in this Section 5 by seeking other employment or otherwise, nor shall the amount of any
payment or benefit provided for in this Section 5 be reduced by any compensation earned by Executive as the result of employment by another employer or self-employment or by retirement benefits; provided, however, that loans, advances or other
amounts owed by Executive to the Company may be offset by the Company against amounts payable to Executive under this Section 5. 
  

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 (g) Return of the Company’s Property. On the Effective Date, Executive shall, as
a condition to Executive’s receipt of any post-termination benefits described in this Agreement, immediately surrender to the Company all lists, books and records of, or in connection with, the Company’s business, and all other property
belonging to the Company, it being distinctly understood that all such lists, books and records, and other documents, are the property of the Company; provided that Executive shall not be required to return any such property that the Company
determines is necessary for Executive’s provision of consulting services pursuant to this Agreement. Executive shall deliver to the Company a signed statement certifying compliance with this Section 5(g) prior to the receipt of any
post-termination benefits described in this Agreement. 
 6. Confidentiality and Proprietary Rights. Executive and the
Company have executed the Company’s Employee Proprietary Information and Inventions Agreement, a copy of which is attached to this Agreement as Exhibit B and incorporated herein by reference. The Company shall be entitled to cease all
severance payments to Executive in the event of his or his breach of this Section 6. 
 7. Agreement to Arbitrate.
Any dispute, claim or controversy based on, arising out of or relating to Executive’s employment or this Agreement shall be settled by final and binding arbitration in San Diego, California, before a single neutral arbitrator in accordance with
the National Rules for the Resolution of Employment Disputes (the “Rules”) of the American Arbitration Association (“AAA”), and judgment on the award rendered by the arbitrator may be entered in any court having jurisdiction.
Arbitration may be compelled pursuant to the California Arbitration Act (Code of Civil Procedure §§ 1280 et seq.). If the parties are unable to agree upon an arbitrator, one shall be appointed by the AAA in accordance with
its Rules. Each party shall pay the fees of its own attorneys, the expenses of its witnesses and all other expenses connected with presenting its case. Other costs of the arbitration, including the cost of any record or transcripts of the
arbitration, AAA’s administrative fees, the fee of the arbitrator, and all other fees and costs, shall be borne by the Company. This Section 7 is intended to be the exclusive method for resolving any and all claims by the parties against
each other for payment of damages under this Agreement or relating to Executive’s employment; provided, however, that neither this Agreement nor the submission to arbitration shall limit the parties’ right to seek provisional relief,
including without limitation injunctive relief, in any court of competent jurisdiction pursuant to California Code of Civil Procedure § 1281.8 or any similar statute of an applicable jurisdiction. Seeking any such relief shall not be
deemed to be a waiver of such party’s right to compel arbitration. Both Executive and the Company expressly waive their right to a jury trial. 
 8. General Provisions. 
 (a) Successors and Assigns. The rights of
the Company under this Agreement may, without the consent of Executive, be assigned by the Company, in its sole and unfettered discretion, to any person, firm, corporation or other business entity which at any

  

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time, whether by purchase, merger or otherwise, directly or indirectly, acquires all or substantially all of the assets or business of the Company. The Company will require any successor (whether
direct or indirect, by purchase, merger or otherwise) to all or substantially all of the business or assets of the Company expressly to assume and to agree to perform this Agreement in the same manner and to the same extent that the Company would be
required to perform it if no such succession had taken place; provided, however, that no such assumption shall relieve the Company of its obligations hereunder. As used in this Agreement, the “Company” shall mean the Company as
hereinbefore defined and any successor to its business and/or assets as aforesaid which assumes and agrees to perform this Agreement by operation of law or otherwise. Executive shall not be entitled to assign any of Executive’s rights or
obligations under this Agreement. This Agreement shall inure to the benefit of and be enforceable by Executive’s personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees and legatees and, in the
event of Executive’s death, the payments and benefits contemplated by Sections 5(b) and 5(c) shall be paid to or made available to Executive’s estate or designated beneficiary. 
 (b) Severability. In the event any provision of this Agreement is found to be unenforceable by an arbitrator or court of competent
jurisdiction, such provision shall be deemed modified to the extent necessary to allow enforceability of the provision as so limited, it being intended that the parties shall receive the benefit contemplated herein to the fullest extent permitted by
law. If a deemed modification is not satisfactory in the judgment of such arbitrator or court, the unenforceable provision shall be deemed deleted, and the validity and enforceability of the remaining provisions shall not be affected thereby.

 (c) Interpretation; Construction. The headings set forth in this Agreement are for convenience only and shall not be
used in interpreting this Agreement. This Agreement has been drafted by legal counsel representing the Company, but Executive has participated in the negotiation of its terms. Furthermore, Executive acknowledges that Executive has had an opportunity
to review and revise the Agreement and have it reviewed by legal counsel, if desired, and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the
interpretation of this Agreement. Either party’s failure to enforce any provision of this Agreement shall not in any way be construed as a waiver of any such provision, or prevent that party thereafter from enforcing each and every other
provision of this Agreement. 
 (d) Governing Law and Venue. This Agreement will be governed by and construed in
accordance with the laws of the United States and the State of California applicable to contracts made and to be performed wholly within such State, and without regard to the conflicts of laws principles thereof. Any suit brought hereon shall be
brought in the state or federal courts sitting in San Diego, California, the Parties hereby waiving any claim or defense that such forum is not convenient or proper. Each party hereby agrees that any such court shall have in personam jurisdiction
over it and consents to service of process in any manner authorized by California law. 
 (e) Notices. Any notice
required or permitted by this Agreement shall be in writing and shall be delivered as follows with notice deemed given as indicated: (a) by

  

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personal delivery when delivered personally; (b) by overnight courier upon written verification of receipt; (c) by telecopy or facsimile transmission upon acknowledgment of receipt of
electronic transmission; or (d) by certified or registered mail, return receipt requested, upon verification of receipt. Notice shall be sent to Executive at the address set forth below and to the Company at its principal place of business, or
such other address as either party may specify in writing. 
 (f) Survival. Sections 1 (“Definitions”), 5
(“Termination and Severance”), 6 (“Confidentiality and Proprietary Rights”), 7 (“Agreement to Arbitrate”) and 8 (“General Provisions”) of this Agreement shall survive termination of Executive’s
employment by or service to the Company. 
 (g) Entire Agreement. This Agreement constitutes the entire agreement between
the parties in respect of the subject matter contained herein and therein and supersede all prior or simultaneous representations, discussions, negotiations, and agreements, whether written or oral, including, without limitation, that certain Change
in Control Severance Agreement dated November 15, 2007, between the Company and Executive, and that certain offer letter dated March 20, 2006, between the Company and Executive. This Agreement may be amended or modified only with the
written consent of Executive and an authorized representative of the Company. No oral waiver, amendment or modification will be effective under any circumstances whatsoever. 
 (h) Code Section 409A Exempt. The compensation and benefits payable under this Agreement, including without limitation the
severance benefits described in Section 5, are not intended to constitute “nonqualified deferred compensation” within the meaning of Section 409A of the Code. To the extent applicable, this Agreement shall be interpreted in
accordance with Code Section 409A and Department of Treasury regulations and other interpretive guidance issued thereunder. If the Company and Executive determine that any compensation or benefits payable under this Agreement may be or become
subject to Code Section 409A and related Department of Treasury guidance, the Company and Executive agree to amend this Agreement or adopt other policies or procedures (including amendments, policies and procedures with retroactive effect), or
take such other actions as the Company and Executive deem necessary or appropriate to (a) exempt the compensation and benefits payable under this Agreement from Code Section 409A and/or preserve the intended tax treatment of the
compensation and benefits provided with respect to this Agreement, or (b) comply with the requirements of Code Section 409A and related Department of Treasury guidance. 
 (i) Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original but all of which
together shall constitute one and the same instrument. 
 (j) Taxes. All compensation payable to Executive hereunder
shall be subject to applicable tax withholding. In the event Executive is a consultant to the Company, Executive shall be solely responsible for taxes required to be paid with respect to his performance of services and the receipt of consideration
under this Agreement, including, without limitation, United States federal, state and local income taxes, payroll taxes, social

  

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security, unemployment or disability insurance, or similar items, and Executive will indemnify Company and hold it harmless from and against all claims, damages, losses and expenses, including
reasonable fees and expenses of attorneys, relating to any obligation imposed by law on Company to pay any withholding taxes, payroll taxes, social security, unemployment or disability insurance, or similar items in connection with consideration
received by Executive pursuant to this Agreement, whether such obligations are imposed by the Internal Revenue Service or any other federal, state or local governmental authority. 
 (K) RIGHT TO ADVICE OF COUNSEL. EXECUTIVE ACKNOWLEDGES THAT HE HAS THE RIGHT, AND IS ENCOURAGED, TO CONSULT WITH HIS LAWYER; BY HIS
SIGNATURE BELOW, EXECUTIVE ACKNOWLEDGES THAT HE UNDERSTANDS THIS RIGHT AND HAS EITHER CONSULTED WITH A LAWYER OR DETERMINED NOT TO DO SO. 
 (Signature Page Follows) 
  

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 THE PARTIES TO THIS AGREEMENT HAVE READ THE FOREGOING AGREEMENT AND FULLY UNDERSTAND EACH
AND EVERY PROVISION CONTAINED HEREIN. WHEREFORE, THE PARTIES HAVE EXECUTED THIS AGREEMENT ON THE DATES SHOWN BELOW. 
  

											
		  		  		  	PROMETHEUS LABORATORIES INC.	 	
						
	 Dated: December 18, 2009
	  		  		  	By:	 	 /s/ Joseph Limber
	 	
		  		  		  	Name:	 	Joseph Limber	 	
		  		  		  	Title:	 	President and CEO	 	
					
		  		  		  	EXECUTIVE	 	
						
	 Dated: December 20, 2009
	  		  		  		 	 /s/ Henry Pan
	 	
		  		  		  		 	Henry Pan	 	

  

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 EXHIBIT A 
 GENERAL RELEASE OF CLAIMS 
 [The language in
this Release may change based on legal developments and evolving best practices; this form is provided as an example of what will be included in the final Release document.] 
 This General Release of Claims (“Release”) is entered into as of this 4th day of January, 2010, between Henry Pan
(“Executive”), and Prometheus Laboratories Inc., a California corporation (the “Company”) (collectively referred to herein as the “Parties”). 
 WHEREAS, Executive and the Company are parties to that certain Employment Transition Agreement effective as of January 4, 2010 (the
“Agreement”); 
 WHEREAS, the Parties agree that Executive is entitled to certain severance benefits
under the Agreement, subject to Executive’s execution of this Release; and 
 WHEREAS, the Company and Executive now wish
to fully and finally to resolve all matters between them. 
 NOW, THEREFORE, in consideration of, and subject to, the severance
benefits payable to Executive pursuant to the Agreement, the adequacy of which is hereby acknowledged by Executive, and which Executive acknowledges that he would not otherwise be entitled to receive, Executive and the Company hereby agree as
follows: 
 1. General Release of Claims by Executive. 
 (a) Executive, on behalf of himself and his executors, heirs, administrators, representatives and assigns, hereby agrees to release and
forever discharge the Company and all predecessors, successors and their respective parent corporations, affiliates, related, and/or subsidiary entities, and all of their past and present investors, directors, shareholders, officers, general or
limited partners, employees, attorneys, agents and representatives, and the employee benefit plans in which Executive is or has been a participant by virtue of his employment with or service to the Company (collectively, the “Company
Releasees”), from any and all claims, debts, demands, accounts, judgments, rights, causes of action, equitable relief, damages, costs, charges, complaints, obligations, promises, agreements, controversies, suits, expenses, compensation,
responsibility and liability of every kind and character whatsoever (including attorneys’ fees and costs), whether in law or equity, known or unknown, asserted or unasserted, suspected or unsuspected (collectively,
“Claims”), which Executive has or may have had against such entities based on any events or circumstances arising or occurring on or prior to the date hereof or on or prior to the date hereof, arising directly or indirectly
out of, relating to, or in any other way involving in any manner whatsoever Executive’s employment by or service to the Company or the termination thereof, including any and all claims arising under federal, state, or local laws relating to
employment, including without limitation claims of wrongful discharge, breach of express or implied contract, fraud, misrepresentation, defamation, or liability in tort, and claims of any kind that may be brought in

 
any court or administrative agency including, without limitation, claims under Title VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. Section 2000, et seq.; the
Americans with Disabilities Act, as amended, 42 U.S.C. § 12101 et seq.; the Rehabilitation Act of 1973, as amended, 29 U.S.C. § 701 et seq.; the Civil Rights Act of 1866, and the Civil Rights
Act of 1991; 42 U.S.C. Section 1981, et seq.; the Age Discrimination in Employment Act, as amended, 29 U.S.C. Section 621, et seq. (the “ADEA”); the Equal Pay Act, as amended, 29 U.S.C.
Section 206(d); regulations of the Office of Federal Contract Compliance, 41 C.F.R. Section 60, et seq.; the Family and Medical Leave Act, as amended, 29 U.S.C. § 2601 et seq.; the Fair
Labor Standards Act of 1938, as amended, 29 U.S.C. § 201 et seq.; the Employee Retirement Income Security Act, as amended, 29 U.S.C. § 1001 et seq.; and the California Fair Employment and Housing
Act, California Government Code Section 12940, et seq. 
 Notwithstanding the generality of the foregoing,
Executive does not release the following claims: 
 (i) Claims for unemployment compensation or any state disability insurance
benefits pursuant to the terms of applicable state law; 
 (ii) Claims for workers’ compensation insurance benefits under
the terms of any worker’s compensation insurance policy or fund of the Company; 
 (iii) Claims pursuant to the terms and
conditions of the federal law known as COBRA; 
 (iv) Claims for indemnity under the bylaws of the Company, as provided for by
California law or under any applicable insurance policy with respect to Executive’s liability as an employee, director or officer of the Company; 
 (v) Claims based on any right Executive may have to enforce the Company’s executory obligations under the Agreement; and 
 (vi) Claims Executive may have to vested or earned compensation and benefits. 
 (b) EXECUTIVE ACKNOWLEDGES THAT HE OR SHE HAS BEEN ADVISED OF AND IS FAMILIAR WITH THE PROVISIONS OF CALIFORNIA CIVIL CODE SECTION 1542,
WHICH PROVIDES AS FOLLOWS: 
 “A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT
TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE, WHICH, IF KNOWN BY HIM OR HER, MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR.” 
 BEING AWARE OF SAID CODE SECTION, EXECUTIVE HEREBY EXPRESSLY WAIVES ANY RIGHTS HE OR SHE MAY HAVE THEREUNDER, AS WELL AS UNDER ANY OTHER
STATUTES OR COMMON LAW PRINCIPLES OF SIMILAR EFFECT. 
  

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 (c) Executive acknowledges that this Release was presented to him on the date indicated
above and that Executive is entitled to have twenty-one (21) days’ time in which to consider it. Executive further acknowledges that the Company has advised him that he or she is waiving his rights under the ADEA, and that Executive should
consult with an attorney of his choice before signing this Release, and Executive has had sufficient time to consider the terms of this Release. Executive represents and acknowledges that if Executive executes this Release before twenty-one
(21) days have elapsed, Executive does so knowingly, voluntarily, and upon the advice and with the approval of Executive’s legal counsel (if any), and that Executive voluntarily waives any remaining consideration period. 
 (d) Executive understands that after executing this Release, Executive has the right to revoke it within seven (7) days after his
execution of it. Executive understands that this Release will not become effective and enforceable unless the seven (7) day revocation period passes and Executive does not revoke the Release in writing. Executive understands that this Release
may not be revoked after the seven (7) day revocation period has passed. Executive also understands that any revocation of this Release must be made in writing and delivered to the Company at its principal place of business within the seven
(7) day period. 
 (e) Executive understands that this Release shall become effective, irrevocable,
and binding upon Executive on the eighth (8th) day
after his execution of it, so long as Executive has not revoked it within the time period and in the manner specified in clause (d) above. Executive further understands that Executive will not be given any severance benefits under the Agreement
unless Executive signs this Release and the applicable revocation period has lapsed on or before the end of the sixty (60) day period following the date of Executive’s termination of employment. 
 2. No Assignment. Executive represents and warrants to the Company Releasees that there has been no assignment or other transfer of
any interest in any Claim that Executive may have against the Company Releasees. Executive agrees to indemnify and hold harmless the Company Releasees from any liability, claims, demands, damages, costs, expenses and attorneys’ fees incurred as
a result of any such assignment or transfer from Executive. 
 3. Severability. In the event any provision of this
Release is found to be unenforceable by an arbitrator or court of competent jurisdiction, such provision shall be deemed modified to the extent necessary to allow enforceability of the provision as so limited, it being intended that the parties
shall receive the benefit contemplated herein to the fullest extent permitted by law. If a deemed modification is not satisfactory in the judgment of such arbitrator or court, the unenforceable provision shall be deemed deleted, and the validity and
enforceability of the remaining provisions shall not be affected thereby. 
 4. Interpretation; Construction. The
headings set forth in this Release are for convenience only and shall not be used in interpreting this Agreement. This Release has been drafted by legal counsel representing the Company, but Executive has participated in the negotiation of its
terms. Furthermore, Executive acknowledges that Executive has had an opportunity to review and revise the Release and have it reviewed by legal counsel, if desired, and, therefore, the normal rule of construction to the effect that any ambiguities
are to be

  

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resolved against the drafting party shall not be employed in the interpretation of this Release. Either party’s failure to enforce any provision of this Release shall not in any way be
construed as a waiver of any such provision, or prevent that party thereafter from enforcing each and every other provision of this Release. 
 5. Governing Law and Venue. This Release will be governed by and construed in accordance with the laws of the United States of America and the State of California applicable to contracts made and
to be performed wholly within such State, and without regard to the conflicts of laws principles thereof. Any suit brought hereon shall be brought in the state or federal courts sitting in San Diego, California, the Parties hereby waiving any claim
or defense that such forum is not convenient or proper. Each party hereby agrees that any such court shall have in personam jurisdiction over it and consents to service of process in any manner authorized by California law. 
 6. Entire Agreement. This Release and the Agreement constitute the entire agreement of the Parties in respect of the subject matter
contained herein and therein and supersede all prior or simultaneous representations, discussions, negotiations and agreements, whether written or oral. This Release may be amended or modified only with the written consent of Executive and an
authorized representative of the Company. No oral waiver, amendment or modification will be effective under any circumstances whatsoever. 
 7. Counterparts. This Release may be executed in multiple counterparts, each of which shall be deemed to be an original but all of which together shall constitute one and the same instrument.

 (Signature Page Follows) 
  

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 IN WITNESS WHEREOF, and intending to be legally bound, the Parties have executed the
foregoing Release as of the date first written above. 
  

											
	 EXECUTIVE
	 		  		  	PROMETHEUS LABORATORIES INC.	  	
						
	 /s/ Henry Pan
	 		  		  	By:	  	 /s/ Joseph Limber
	  	
	 Print Name: Henry Pan
	 		  		  	Print Name:	  	Joseph Limber	  	
		 		  		  	Title:	  	President and CEO	  	

  

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 EXHIBIT B 
 EMPLOYEE PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 
 [ATTACHED]First Amendment Dated 01/25/2010 to Lease

 Exhibit 10.44 
 FIRST AMENDMENT 
 THIS FIRST AMENDMENT (the “Amendment”) is made and
entered into as of January 25, 2010, by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, (“Landlord”) and PROMETHEUS LABORATORIES INC., a California corporation (“Tenant”). 
 RECITALS 
  

	A.	 Landlord (formerly known as The Irvine Company, a Delaware corporation) and Tenant are parties to that certain lease dated June 22, 2005 (the
“Lease”). Pursuant to the Lease, Landlord has leased to Tenant space currently containing approximately 99,041 rentable square feet (the “Original Premises”) described as the 1st floor of the building located at 9410 Carroll Park Drive, San Diego, California (the “Building”).

  

	B.	 Tenant has requested that additional space containing approximately 11,000 rentable square feet on the mezzanine level (the “Mezzanine”) of
the Building shown on Exhibit A hereto (the “Expansion Space”) be added to the Original Premises and that the Lease be appropriately amended and Landlord is willing to do the same on the following terms and conditions.

 NOW, THEREFORE, in consideration of the above recitals which by this reference are
incorporated herein, the mutual covenants and conditions contained herein and other valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 
  

	I.	 Expansion and Effective Date. Effective as of November 1, 2009 (the “Expansion Effective Date”), the Premises, as defined
in the Lease, is increased from 99,041 rentable square feet on the 1st floor
to 110,041 rentable square feet on the 1st floor and the Mezzanine level by
the addition of the Expansion Space, and from and after the Expansion Effective Date, the Original Premises and the Expansion Space, collectively, shall be deemed the Premises, as defined in the Lease. The Term for the Expansion Space shall commence
on the Expansion Effective Date and end on the Expiration Date (i.e., December 31, 2012). The Expansion Space is subject to all the terms and conditions of the Lease except as expressly modified herein and Tenant shall not be entitled to
receive any allowances, abatements or other financial concessions granted with respect to the Original Premises or the Expansion Space, except as set forth herein or in the Lease. 

  

	II.	 Basic Rent. In addition to Tenant’s obligation to pay Basic Rent for the Original Premises, Tenant shall pay Landlord Basic Rent for the
Expansion Space as follows: 

  

					
	 Months of Term
 or Period
	  	 Monthly Rate Per
 Square Foot
	  	Monthly Basic Rent
	11/1/09 – 12/31/09	  	$0.52	  	$5,720.00
	1/1/10 – 12/31/10	  	$0.535	  	$5,885.00
	1/1/11 – 12/31/11	  	$0.55	  	$6,050.00
	1/1/12 – 12/31/12	  	$0.565	  	$6,215.00

 All such Basic Rent shall be payable by Tenant in accordance with the terms of the Lease. 
  

	III.	 Project Costs and Property Taxes. For the period commencing on the Expansion Effective Date and ending on the Expiration Date, Tenant shall be
obligated to pay Tenant’s Share of Property Taxes accruing in connection with the Expansion Space in accordance with the Lease. For the purposes of clarity, Tenant shall be responsible for the payment of supplemental Property Taxes assessed, if
any, solely with respect to the addition of the square footage in the Expansion Space and not for any other improvements. Landlord represents and warrants that no other tenant in the Project has expanded its space during the term of this Lease for
which Tenant has been assessed additional charges. Landlord acknowledges and agrees that if, in the future, any other tenant in the Project expands its space, Tenant shall not be responsible for any supplemental taxes or charges due to such
expansion. 

  

	IV.	 Additional Security Deposit. No additional security deposit shall be required in connection with this Amendment. 

 

	V.	 Improvements to Expansion Space. 

  

	 	A.	 Condition of Expansion Space. Tenant has inspected the Expansion Space and agrees to accept the same “as is” without any agreements,
representations, understandings or obligations on the part of Landlord to perform any alterations, repairs or improvements, except as may be expressly provided otherwise in this Amendment. 

  

	 	B.	 Any construction, alterations or improvements to the Expansion Space shall be performed by Tenant at its sole cost and expense using contractors selected by
Tenant and approved by Landlord and shall be governed in all respects by the provisions of Section 7.3 of the Lease. Landlord, to the best of the actual knowledge of the on-site project manager, Mark Breeden, has no actual knowledge of any
failure of Tenant to comply with the terms and provisions contained therein. Nothing contained herein shall be deemed a representation by Landlord that Tenant has fully complied with Section 7.3 of the Lease. 

  

 1 

	VI.	 Parking. Tenant shall not be entitled to any additional parking spaces in connection with the Expansion Space. 

  

	VII.	 SDN List. Tenant hereby represents and warrants that, to the best of its knowledge, neither Tenant nor any officer, director, controlling or
managing partner, member or other principal of Tenant (collectively, “Tenant Parties”) is listed as a Specially Designated National and Blocked Person (“SDN”) on the list of such persons and entities issued by the U.S. Treasury
Office of Foreign Assets Control (OFAC). 

  

	VIII.	 Other Pertinent Provisions. Landlord and Tenant agree that, effective as of the date of this Amendment (unless different effective date(s)
is/are specifically referenced in this Section), the Lease shall be amended in the following additional respects: 

  

	 	A.	 Restoration of Expansion Space. Upon Landlord’s request, Tenant shall restore the Expansion Space on or prior to the Expiration Date to its
original condition, reasonable wear and tear excepted. Tenant’s out-of-pocket costs for such restoration shall not exceed $100,000.00. Notwithstanding the foregoing, in the event Tenant renews the Lease for a minimum of 3 years following the
Expiration Date, Tenant’s restoration obligation set forth herein shall be waived. 

  

	 	B.	 Payment and Notice. Landlord’s addresses for payment of rent and notices in accordance with Article I, Item 13 (Basic Lease Provisions) shall
be deleted in their entirety and the following substituted in lieu thereof: 

 “Payment Address:

 The Irvine Company LLC 
 Department #6421 
 Los Angeles, CA 90084-6421 
 Notice Address: 
 The Irvine Company LLC 
 9171 Towne Center Drive, Suite 140 
 San Diego, Ca 92122 
 Attn: Property Manager 
 with a copy of notices to: 
 THE IRVINE COMPANY LLC 
 P.O. Box 6370 
 Newport Beach, CA 92658-6370 

			
	 Attn:
	 	 Vice President, Operations,

		 	 Office Properties/San Diego”

  

	IX.	 GENERAL. 

  

	 	A.	 Effect of Amendments. The Lease shall remain in full force and effect except to the extent that it is modified by this Amendment.

  

	 	B.	 Entire Agreement. This Amendment and the Lease embody the entire understanding between Landlord and Tenant and can be changed only by a writing signed
by Landlord and Tenant. There have been no additional oral or written representations or agreements. Under no circumstances shall Tenant be entitled to any rent abatement, improvement allowance, leasehold improvements, or any similar economic
incentives that may have been provided Tenant in connection with entering into the Lease, unless specifically set forth in this Amendment. 

  

	 	C.	 Counterparts. If this Amendment is executed in counterparts, each is hereby declared to be an original; all, however, shall constitute but one and the
same amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation. 

  

	 	D.	 Defined Terms. All words commencing with initial capital letters in this Amendment and defined in the Lease shall have the same meaning in this
Amendment as in the Lease, unless they are otherwise defined in this Amendment. 

  

	 	E.	 Authority. If Tenant is a corporation, limited liability company or partnership, or is comprised of any of them, each individual executing this
Amendment for the corporation, limited liability company or partnership represents that he or she is duly authorized to execute and deliver this Amendment on behalf of such entity and that this Amendment is binding upon such entity in accordance
with its terms. 

  

 2 

	 	F.	 Attorneys’ Fees. The provisions of the Lease respecting payment of attorneys' fees shall also apply to this Amendment.

  

	 	G.	 Execution of Amendment. Submission of this Amendment by Landlord is not an offer to enter into this Amendment but rather is a solicitation for such an
offer by Tenant. Neither party shall be bound by this Amendment until the parties have executed and delivered the same to the other party. 

  

	 	H.	 Nondisclosure of Terms. Tenant hereby acknowledges that the provisions of Section 22.1 of the Lease (Nondisclosure of Lease Terms) is hereby
restated and in full force and effect relative to the terms and conditions of this Amendment and any other subsequent amendment, agreement, or other modification of the Lease. 

 IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the day and year first above written.

  

									
	 LANDLORD:
	 		 	 TENANT:

			
	 THE IRVINE COMPANY LLC,
 a Delaware limited liability company
	 		 	 PROMETHEUS LABORATORIES INC.,
 a California corporation

					
	 By:
	 	
 

	 		 	 By:
	 	
 

		 	 Steven M. Case
	 		 	 Printed Name:
	 	 Joseph M. Limber

		 	 Executive Vice President
 Office Properties
	 		 	 Title:
	 	 President & CEO

					
	 By:
	 	
 

	 		 	 By:
	 	
 

		 	 Michael T. Bennett
	 		 	 Printed Name:
	 	 Mark E. Spring

		 	 Senior Vice President, Operations
 Office Properties
	 		 	 Title:
	 	 Sr VP Finance & CFO

 

 

 

 

  

 3 

 

 

 9410 Carroll Park Drive 
 Mezzanine Addition 

 

 

 Exhibit A 
  

 1

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