Document:

Form of Floating Rate Security

 Exhibit 4.1 

[FORM OF FLOATING RATE SECURITY] 

INTEREST PAYMENTS ON THIS SECURITY GENERALLY WILL BE SUBJECT TO JAPANESE WITHHOLDING TAX UNLESS IT IS ESTABLISHED THAT THIS SECURITY IS HELD
BY OR FOR THE ACCOUNT OF A BENEFICIAL OWNER THAT IS (I) FOR JAPANESE TAX PURPOSES, NEITHER AN INDIVIDUAL RESIDENT OF JAPAN OR A JAPANESE CORPORATION, NOR AN INDIVIDUAL NON-RESIDENT OF JAPAN OR A NON-JAPANESE CORPORATION THAT IN EITHER CASE IS A PERSON HAVING A SPECIAL RELATIONSHIP WITH MIZUHO FINANCIAL GROUP, INC. AS DESCRIBED IN ARTICLE 6, PARAGRAPH (4) OF THE ACT ON SPECIAL MEASURES CONCERNING
TAXATION OF JAPAN (ACT NO. 26 OF 1957, AS AMENDED) (THE “SPECIAL TAXATION MEASURES ACT” AND, EACH SUCH PERSON, A “SPECIALLY-RELATED PERSON OF THE COMPANY”), (II) A JAPANESE DESIGNATED FINANCIAL INSTITUTION DESCRIBED
IN ARTICLE 6, PARAGRAPH (11) OF THE SPECIAL TAXATION MEASURES ACT WHICH COMPLIES WITH THE REQUIREMENT FOR TAX EXEMPTION UNDER THAT PARAGRAPH OR (III) A JAPANESE PUBLIC CORPORATION, A JAPANESE FINANCIAL INSTITUTION OR A JAPANESE FINANCIAL
INSTRUMENTS BUSINESS OPERATOR DESCRIBED IN ARTICLE 3-3, PARAGRAPH (6) OF THE SPECIAL TAXATION MEASURES ACT WHICH COMPLIES WITH THE REQUIREMENT FOR TAX EXEMPTION UNDER THAT PARAGRAPH. 

INTEREST PAYMENTS ON THIS SECURITY TO AN INDIVIDUAL RESIDENT OF JAPAN, TO A JAPANESE CORPORATION NOT DESCRIBED IN THE PRECEDING PARAGRAPH, OR
TO AN INDIVIDUAL NON-RESIDENT OF JAPAN OR A NON-JAPANESE CORPORATION THAT IN EITHER CASE IS A SPECIALLY-RELATED PERSON OF THE COMPANY WILL BE SUBJECT TO DEDUCTION IN
RESPECT OF JAPANESE INCOME TAX AT A RATE OF 15.315% (15% ON OR AFTER JANUARY 1, 2038) OF THE AMOUNT OF SUCH INTEREST. 

  
 1 

 MIZUHO FINANCIAL GROUP, INC. 

GLOBAL SECURITY 
 Senior Callable
Floating Rate Notes Due [                ] 
  

			
	No. [            ]	  	CUSIP No.: [            ]
	 	  	ISIN No.: [            ]
	 	  	Common Code: [            ]
	 	  	$[                    ]

 MIZUHO FINANCIAL GROUP, INC., a joint stock company (kabushiki kaisha) organized under the laws of
Japan (the “Company”, which term includes any successor corporation), for value received promises to pay to CEDE & CO., or registered assigns, the principal sum of
$[                ] (the “Principal”) on [                ],
20[    ] (the “Maturity Date”) and to pay interest thereon from [                ], 20[    ] or from the most
recent interest payment date to which interest has been paid or duly provided for, [semi-annually/quarterly] in arrears on [[                ],
[                ],] [                ] and
[                ] in each year (each, an “Interest Payment Date”) commencing
[                ], 20[    ] at the Floating Interest Rate (as defined on the reverse of this Security), all subject to and in accordance with the
terms of the Indenture referred to herein. 
 The interest so payable, and punctually paid or duly provided for, on any Interest Payment
Date will, as provided in the Indenture, be paid to the person in whose name this Security is registered as at 5:00 p.m. (New York time) on the fifth Business Day immediately preceding such Interest Payment Date. If and to the extent the Company
shall default in the payment of the interest due on such Interest Payment Date, such defaulted interest shall be paid to the person in whose name this Security is registered at the close of business on a subsequent record date, which shall not be
less than five Business Days prior to the payment of such defaulted interest, established by notice given by mail by or on behalf of the Company to the Holder of this Security not less than fifteen days preceding such subsequent record date.
Interest on this Security will accrue from the date of original issuance or, if interest has already been paid, from the date it was most recently paid. 

If any Interest Payment Date, other than the Maturity Date or the date fixed for redemption, falls on a day that is not a Business Day, the
Interest Payment Date shall be adjusted in accordance with the Modified Following Business Day Convention. As used herein, the “Modified Following Business Day Convention” means that the relevant date shall be postponed to the first
following day that is a Business Day (and interest will continue to accrue to, but excluding, such succeeding Business Day), unless that day falls in the next calendar month in which case that date will be the first preceding day that is a Business
Day (and interest will accrue to, but excluding, such preceding Business Day). In the event the Maturity Date or the date fixed for redemption falls on a day that is not a Business Day, then any interest, principal or Additional Amounts, if any, as
the case may be, will be paid on the next succeeding day that is a Business Day, and no interest on such payment shall accrue due to such postponement for the period from and after the Maturity Date or the date fixed for redemption. As used herein,
the term “Business Day” means a day which is a U.S. Government Securities Business Day (as defined on the reverse of this Security) and which is not a day on which banking institutions in The City of New York or Tokyo are authorized
by law or regulation to close. 

  
 2 

 The principal of, and interest and Additional Amounts on, the Securities will be payable in
U.S. dollars. The Company will cause the Trustee, or the paying agent, if any, to pay such amounts, on the dates payment is to be made, directly to The Depository Trust Company (“DTC”). 

The Company will pay the Holder hereof Additional Amounts with respect to withholding taxes as are provided for, and subject to the conditions
stated, on the reverse of this Security. 
 This Security is being deposited with DTC acting as depository, and registered in the name of
Cede & Co., a nominee of DTC. As Holder of record of this Security, Cede & Co. shall be entitled to receive payments of principal and interest. Payments of principal and interest, including any Additional Amounts, on this Security
shall be made in the manner specified on the reverse hereof and, to the extent not inconsistent with the provisions set forth herein, in the Indenture referred to herein. 

The Securities constitute the direct, unconditional, unsubordinated and unsecured obligations of the Company and shall at all times rank
pari passu and without preference among themselves and with all other unsecured obligations, other than subordinated obligations, of the Company (except for statutorily preferred exceptions) from time to time outstanding. The Securities are
not redeemable prior to maturity, except as set forth on the reverse of this Security and will not be subject to any sinking fund. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been manually executed
by or on behalf of the Trustee under the Indenture, this Security shall not be entitled to any benefits under the Indenture or be valid or obligatory for any purpose. 

  
 3 

 IN WITNESS WHEREOF, the Company has caused this Security to be signed manually or by
facsimile by its duly authorized signatory. 
  

			
	 MIZUHO FINANCIAL GROUP, INC.

		
	 By:
	 	  

		 	 Name:
[                ]

		 	
Title:   [               
 ]

  
 4 

 Certificate of Authentication 

This is one of the series designated herein and referred to in the within-mentioned Indenture. 

Date:                  

 

			
	 THE BANK OF NEW YORK MELLON,
 as
Trustee

		
	By:	 	  

		 	Name: [                ]
		 	Title:   [                ]

  
 5 

 REVERSE OF SECURITY 

MIZUHO FINANCIAL GROUP, INC. 

Senior Callable Floating Rate Notes Due 20[    ] 

This Security is one of a duly authorized issue of unsecured debentures, notes or other evidences of indebtedness of Mizuho Financial Group,
Inc., a joint stock company organized under the laws of Japan (herein called the “Company”, which term includes any successor person under the Indenture hereinafter referred) designated as its Senior Floating Rate Notes due
[                ], 20[    ] (herein called the “Securities”), issued under and pursuant to an Indenture dated as of
September 13, 2016 (hereinafter called the “Indenture”), between the Company and The Bank of New York Mellon, as trustee (herein called the “Trustee”, which term includes any successor trustee under the
Indenture), to which Indenture and any other indentures supplemental thereto reference is hereby made for a statement of the respective rights, limitations of rights, obligations, duties and immunities thereunder of the Trustee and any agent of the
Trustee, any paying agent, the Company and the Holders of the Securities and of the terms upon which the Securities are issued and are to be authenticated and delivered. 

This Security is one of the series designated on the face hereof. By the terms of the Indenture, additional Securities of this series and of
other separate series, which may vary as to denomination, date, amount, stated maturity (if any), interest rate or method of calculating the interest rate and in other respects as therein provided, may be issued in an unlimited amount. 

On each Interest Determination Date (as defined below), the Calculation Agent (as defined below) will calculate the amount of accrued interest
payable on the Securities on the related Interest Payment Date by multiplying (i) the principal amount of such Securities by (ii) the product of (a) the Floating Interest Rate for the relevant Interest Period multiplied by
(b) the number of days in the relevant Interest Period divided by 360 and rounding the resulting figure to the nearest cent (half a cent being rounded upwards). In no event shall the Floating Interest Rate for this Security be more than the
maximum rate permitted by applicable laws and regulations or less than 0% for any Interest Period. 
 The “Floating Interest
Rate” for each Interest Period means a rate per annum equal to Compounded Daily SOFR (as defined below) plus [                ]% (the
“Margin”). In accordance with the Benchmark Transition Provisions (as defined below), after a Benchmark Transition Event (as defined below) and its related Benchmark Replacement Date (as defined below) have occurred, the rate of
interest payable for each Interest Period on the Securities will be an annual rate equal to the sum of the Benchmark Replacement (as defined below) and the Margin. 

Compounded Daily SOFR 

  
 6 

 The term “Compounded Daily SOFR” means, in respect of each Interest Period,
the rate of return on a daily compounded interest investment during the relevant SOFR Observation Period (with the daily SOFR reference rate as the reference rate for the calculation of interest) and will be determined by the Calculation Agent on
the relevant Interest Determination Date in accordance with the following formula: 
  
 

 
 with the resulting percentage being rounded, if necessary, to the nearest one hundred-thousandth of a percentage point,
with 0.000005 per cent. being rounded upwards (e.g., 9.876541 per cent. (or 0.09876541) being rounded down to 9.87654 per cent. (or 0.0987654) and 9.876545 per cent. (or 0.09876545) being rounded up to 9.87655 per cent. (or
0.0987655)) and where: 
  

	 	•	 	 “SOFRi” for any U.S. Government Securities
Business Day “i” in the relevant SOFR Observation Period, is equal to the SOFR reference rate for that U.S. Government Securities Business Day “i”; 

 

	 	•	 	 “d” means the number of calendar days in the relevant SOFR Observation Period; 

 

	 	•	 	 “do” means the number of U.S. Government
Securities Business Days in the relevant SOFR Observation Period; 

  

	 	•	 	 “i” means a series of whole numbers ascending from one to do, representing each U.S. Government Securities Business Day in chronological order from (and including) the first U.S. Government Securities Business Day in the relevant SOFR Observation Period
(each, a “U.S. Government Securities Business Day “i””); and 

  

	 	•	 	 “ni”, for any U.S. Government Securities
Business Day “i”, means the number of calendar days from (and including) such U.S. Government Securities Business Day “i” up to (but excluding) the following U.S. Government Securities Business Day. 

Certain Defined Terms. As used herein: 

“Interest Determination Date” means the date that is five Business Days before the related Interest Payment Date (or
(i) in the final Interest Period, before the Maturity Date, or (ii) in the case of a redemption of the Securities, before the redemption date). 

“Interest Period” means each period beginning from (and including) any Interest Payment Date to (but excluding) the next
Interest Payment Date. For purposes of the first interest payment on [                ], 20[    ], the Interest Period shall begin on (and include)
[                ], 20[    ]. For purposes of the interest payment on the Maturity Date or the date fixed for redemption, the Interest Period shall
end on (and exclude) [                ], 20[    ] or the date fixed for redemption; provided, however, that, in the case of any Interest
Period during which any Securities become due and payable on a date other than an Interest Payment Date, such Interest Period will end on (but exclude) such date on which such Securities have become due and payable.  

  
 7 

 “SOFR” means, in respect of a U.S. Government Securities Business Day, the
reference rate determined by the Calculation Agent in accordance with the following provision: 
  

	 	(i)	 the Secured Overnight Financing Rate published for such U.S. Government Securities Business Day at the SOFR
Determination Time on the SOFR Administrator’s Website; or 

  

	 	(ii)	 if the reference rate specified in (i) above does not appear, unless both a Benchmark Transition Event and
its related Benchmark Replacement Date (each as defined below) have occurred, the Secured Overnight Financing Rate published on the SOFR Administrator’s Website for the most recent preceding U.S. Government Securities Business Day for which the
Secured Overnight Financing Rate was published on the SOFR Administrator’s Website. 

 “SOFR
Administrator’s Website” means the website of the Federal Reserve Bank of New York, or any successor source. 
 “SOFR
Determination Time” means 3:00 p.m. (New York City time) on the immediately following U.S. Government Securities Business Day. 

“SOFR Observation Period” means (i) in respect of each Interest Period, the period from, and including, the date that is
five Business Days preceding the first date in such Interest Period to, but excluding, the date that is five Business Days preceding the Interest Payment Date for such Interest Period, and (ii) in respect of the payment of any interest in
connection with any redemption of the Securities, the period from, and including, the date that is five Business Days preceding the first date in the Interest Period in which such redemption occurs to, but excluding, the date that is five Business
Days before such redemption date. 
 “U.S. Government Securities Business Day” means any day except for a Saturday, a
Sunday or a day on which the Securities Industry and Financial Markets Association recommends that the fixed income departments of its members be closed for the entire day for purposes of trading in U.S. government securities. 

End of “Compounded Daily SOFR” section 

[                ] will serve as calculation agent (in such
capacity together with any successor, the “Calculation Agent”) for the Securities. 
 In the absence of gross negligence,
willful default or manifest error, the Calculation Agent’s determination of Compounded Daily SOFR and its calculation of the applicable Floating Interest Rate and amount for each Interest Period will be conclusive and binding on the Company,
its Designee, the Trustee, the Paying Agent and the holders of the Securities. The Calculation Agent will make available the Floating Interest Rates for current and preceding Interest Periods by delivery of such notice to the Company, the Trustee,
the Paying Agent and DTC, and, upon the request or direction by the Company, such information will be notified or published to the holders of the Securities through DTC or through another reasonable manner as soon as possible after their
determination. The Company has the right to remove the Calculation Agent at any time, which removal will take effect on the date of the appointment by the Company of a successor Calculation Agent. 

  
 8 

 Notwithstanding anything to the contrary in the Indenture or herein, if the Company or its
Designee determines prior to the relevant Reference Time (as defined below) that a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with respect to determining Compounded Daily SOFR or the then-current Benchmark
(as defined below), then the benchmark replacement provisions set forth under the heading “Effect of Benchmark Transition Event” below (the “Benchmark Transition Provisions”) will thereafter apply to all determinations,
calculations and quotations made or obtained for the purpose of calculating the rate and amount of interest payable on the Securities. 
 Effect of
Benchmark Transition Event 
 Benchmark Replacement. Notwithstanding anything to the contrary in the Indenture or herein, if the
Company or its Designee determines prior to the relevant Reference Time that a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with respect to the-then current Benchmark,
the Benchmark Replacement will replace the then-current Benchmark for all purposes relating to the Securities in respect of all determinations on the date on which such relevant Reference Time falls and for all determinations on all subsequent
dates. 
 Benchmark Replacement Conforming Changes. In connection with the implementation of a Benchmark Replacement, the Company or
its Designee will have the right to make Benchmark Replacement Conforming Changes from time to time. 
 Decisions and Determinations.
Any determination, decision or election that may be made by the Company or its Designee pursuant to the Benchmark Transition Provisions, including any determination with respect to a tenor, rate or adjustment or of the occurrence or non-occurrence of an event, circumstance or date, and any decision to take or refrain from taking any action or any selection: 
  

	 	(i)	 will be conclusive and binding on the Company, its Designee, the Trustee, the Paying Agent, the Calculation
Agent and any other agents and the holders of the Securities absent manifest error; 

  

	 	(ii)	 if made by the Company, will be made in the Company’s sole discretion; 

 

	 	(iii)	 if made by the Company’s Designee, will be made after consultation with the Company, and the Designee will
not make any such determination, decision or election to which the Company objects; and 

  

	 	(iv)	 notwithstanding anything to the contrary in the Indenture or herein, shall become effective without consent
from the holders of the Securities or any other party. 

 Any determination, decision or election pursuant to the
Benchmark Transition Provisions not made by the Company’s Designee may be made by the Company on the basis as described above. In addition, notwithstanding anything to the contrary in the Indenture or herein, the Company may designate as its
Designee an entity, which may be the Company’s affiliate, to make any determination, decision or election that the Company has the right to make in connection with the Benchmark Transition Provisions. 

  
 9 

 The Company or its Designee will promptly give notice of the determination of the Benchmark
Replacement, the Benchmark Replacement Adjustment and any Benchmark Replacement Conforming Changes to the Calculation Agent; provided that failure to give such notice will have no impact on the effectiveness of, or otherwise invalidate, any
such determination. 
 Certain Defined Terms. As used herein: 

“Benchmark” means, initially, Compounded Daily SOFR; provided that if the Company or its Designee determines prior to
the Reference Time that a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with respect to Compounded Daily SOFR (including any daily published component used in the calculation thereof) or the then-current
Benchmark, then “Benchmark” means the applicable Benchmark Replacement. 
 “Benchmark Replacement” means the
first alternative set forth in the order below that can be determined by the Company or its Designee as of the Benchmark Replacement Date: 
  

	 	(i)	 the sum of: 

  

	 	(a)	 the alternate reference rate that has been selected or recommended by the Relevant Governmental Body as the
replacement for the then-current Benchmark (including any daily published component used in the calculation thereof) for the applicable Corresponding Tenor; and 

 

	 	(b)	 the Benchmark Replacement Adjustment; 

 

	 	(ii)	 the sum of: 

  

	 	(a)	 the ISDA Fallback Rate; and 

 

	 	(b)	 the Benchmark Replacement Adjustment; or 

 

	 	(iii)	 the sum of: 

  

	 	(a)	 the alternate reference rate that has been selected by the Company or its Designee as the replacement for the
then-current Benchmark (including any daily published component used in the calculation thereof) for the applicable Corresponding Tenor giving due consideration to any industry-accepted reference rate as a replacement for the then-current Benchmark
(including any daily published component used in the calculation thereof) for U.S. dollar-denominated floating rate notes at such time; and 

  

	 	(b)	 the Benchmark Replacement Adjustment. 

  
 10 

 “Benchmark Replacement Adjustment” means the first alternative set forth in
the order below that can be determined by the Company or its Designee as of the Benchmark Replacement Date: 
  

	 	(1)	 the spread adjustment, or method for calculating or determining such spread adjustment, (which may be a
positive or negative value or zero) that has been selected or recommended by the Relevant Governmental Body for the applicable Unadjusted Benchmark Replacement; 

 

	 	(2)	 if the applicable Unadjusted Benchmark Replacement is equivalent to the ISDA Fallback Rate, the ISDA Fallback
Adjustment; or 

  

	 	(3)	 the spread adjustment (which may be a positive or negative value or zero) that has been selected by the Company
or its Designee giving due consideration to any industry-accepted spread adjustment, or method for calculating or determining such spread adjustment, for the replacement of the then-current Benchmark (including any daily published component used in
the calculation thereof) with the applicable Unadjusted Benchmark Replacement for U.S. dollar-denominated floating rate notes at such time. 

“Benchmark Replacement Conforming Changes” means, with respect to any Benchmark Replacement, any technical, administrative or
operational changes (including changes to the definitions or interpretations of “Interest Period,” changes to the timing and frequency of determining rates and making payments of interest, rounding of amounts or tenors, and other
administrative matters) that the Company or its Designee decides may be appropriate to reflect the adoption of such Benchmark Replacement in a manner substantially consistent with market practice (or, if the Company or its Designee decides that
adoption of any portion of such market practice is not administratively feasible or if the Company or its Designee determines that no market practice for use of the Benchmark Replacement exists, in such other manner as the Company or its Designee
determines is reasonably necessary). 
 “Benchmark Replacement Date” means the earliest to occur of the following events
with respect to the then-current Benchmark (including any daily published component used in the calculation thereof): 
  

	 	(1)	 in the case of clause (1) or (2) of the definition of “Benchmark Transition Event,” the later of
(a) the date of the public statement or publication of information referenced therein and (b) the date on which the administrator of the Benchmark permanently or indefinitely ceases to provide the Benchmark (or such component); or

  

	 	(2)	 in the case of clause (3) of the definition of “Benchmark Transition Event,” the date of the
public statement or publication of information referenced therein. 

  
 11 

 For the avoidance of doubt, if the event giving rise to the Benchmark Replacement Date
occurs on the same day as, but earlier than, the Reference Time in respect of any determination, the Benchmark Replacement Date will be deemed to have occurred prior to the Reference Time for such determination. 

“Benchmark Transition Event” means the occurrence of one or more of the following events with respect to the then-current
Benchmark (including any daily published component used in the calculation thereof): 
  

	 	(1)	 a public statement or publication of information by or on behalf of the administrator of the Benchmark (or such
component) announcing that such administrator has ceased or will cease to provide the Benchmark (or such component), permanently or indefinitely, provided that, at the time of such statement or publication, there is no successor administrator that
will continue to provide the Benchmark (or such component); 

  

	 	(2)	 a public statement or publication of information by the regulatory supervisor for the administrator of the
Benchmark (or such component), the central bank for the currency of the Benchmark (or such component), an insolvency official with jurisdiction over the administrator for the Benchmark (or such component), a resolution authority with jurisdiction
over the administrator for the Benchmark (or such component) or a court or an entity with similar insolvency or resolution authority over the administrator for the Benchmark, which states that the administrator of the Benchmark (or such component)
has ceased or will cease to provide the Benchmark (or such component) permanently or indefinitely, provided that, at the time of such statement or publication, there is no successor administrator that will continue to provide the Benchmark (or such
component); or 

  

	 	(3)	 a public statement or publication of information by the regulatory supervisor for the administrator of the
Benchmark announcing that the Benchmark is no longer representative. 

 “Corresponding Tenor” with
respect to a Benchmark Replacement means a tenor (including overnight) having approximately the same length (disregarding business day adjustment) as the applicable tenor for the then-current Benchmark. 

“Designee” means a designee as selected and separately appointed by the Company as designee for the Securities in writing.

 “ISDA Definitions” means the 2021 ISDA Interest Rate Derivatives Definitions published by the International Swaps and
Derivatives Association, Inc. or any successor thereto, as amended or supplemented from time to time, or any successor definitional booklet for interest rate derivatives published from time to time. 

  
 12 

 “ISDA Fallback Adjustment” means the spread adjustment (which may be a
positive or negative value or zero) that would apply for derivatives transactions referencing the ISDA Definitions to be determined upon the occurrence of an index cessation event with respect to the Benchmark for the applicable tenor. 

“ISDA Fallback Rate” means the rate that would apply for derivatives transactions referencing the ISDA Definitions to be
effective upon the occurrence of an index cessation date with respect to the Benchmark (including any daily published component used in the calculation thereof) for the applicable tenor excluding the applicable ISDA Fallback Adjustment. 

“Reference Time” with respect to any determination of the Benchmark means (1) if the Benchmark is the Compounded Daily
SOFR, the SOFR Determination Time, or (2) if the Benchmark is not the Compounded Daily SOFR, the time determined by the Company or its Designee after giving effect to the Benchmark Replacement Conforming Changes. 

“Relevant Governmental Body” means the Federal Reserve Board and/or the Federal Reserve Bank of New York, or a committee
officially endorsed or convened by the Federal Reserve Board and/ or the Federal Reserve Bank of New York or any successor thereto. 

“Unadjusted Benchmark Replacement” means the Benchmark Replacement excluding the Benchmark Replacement Adjustment. 

End of “Effect of Benchmark Transition Event” section 

The principal of and interest (and any Additional Amounts) on the Securities shall be payable in U.S. Dollars or in such other coin or currency
of the United States of America as at the time of payment is legal tender for the payment of public and private debts. So long as any of the Securities are held in global form, payments of principal and interest on such Securities shall be made by
wire transfer in immediately available funds in U.S. Dollars to a bank account in The City of New York designated by the Holder of this Registered Global Security. Otherwise, if the Securities are in certificated form and the Company acts as its own
paying agent, (i) the principal amount of the Securities will be payable by check, drawn on a bank in The City of New York, upon the presentation and surrender of the Securities at the Specified Corporate Trust Office of the Trustee or at any
office or agency maintained by the Company for such purpose and (ii) interest on the Securities will be payable by wire transfer or check, drawn on a bank in The City of New York, mailed to the persons in whose names the Securities are
registered as of 5:00 p.m. (New York time) on the fifth Business Day immediately preceding the applicable Interest Payment Date (or the subsequent record date in the case of a defaulted interest payment) at the addresses of such persons as shall
appear in the Security register of the Company; provided, however, that at the option of a Holder in whose name at least $10,000,000 principal amount of Securities are registered, all payments in respect of the Securities may be received by
electronic funds transfer of immediately available funds to a U.S. dollar account maintained by the payee, provided such registered Holder so elects by giving written notice to the Paying Agent designating such account, no later than fifteen days
immediately preceding the relevant date for payment (or such other date as the Paying Agent may accept in its discretion). 

  
 13 

 All payments of principal and interest in respect of the Securities by the Company shall be
made without withholding or deduction for, or on account of, any present or future taxes, duties, assessments, levies or governmental charges of whatever nature imposed or levied by or on behalf of Japan, or any political subdivision of, or any
authority in, or of, Japan having power to tax (“Japanese Taxes”), unless such withholding or deduction is required by law. In that event, the Company shall pay to the holder of each Security such additional amounts (all such
amounts being referred to herein as “Additional Amounts”) as may be necessary so that the net amounts received by it after such withholding or deduction shall equal the respective amounts which would have been receivable in respect
of such Security in the absence of such withholding or deduction, provided that, no such Additional Amounts shall be payable in relation to any such withholding or deduction in respect of any payment on the Securities: 

(a) to or on behalf of a Securityholder or beneficial owner of a Security who is an individual
non-resident of Japan or a non-Japanese corporation and is liable for such Japanese Taxes in respect of such Security by reason of its (1) having some connection
with Japan other than the mere holding of such Security, or (2) being a person having a special relationship with the Company as described in Article 6, Paragraph 4 of the Act on Special Measures Concerning Taxation of Japan (Act No. 26 of
1957) (the “Special Taxation Measures Act”) (a “Specially-Related Person of the Company”); or 
 (b)
to or on behalf of a Securityholder or beneficial owner of a Security (A) who would be exempt from any such withholding or deduction but who fails to comply with any applicable requirement to provide certification, information, documents or
other evidence concerning its nationality, residence, identity or connection with Japan, including any requirement to provide Interest Recipient Information (as defined below) or to submit a Written Application for Tax Exemption (as defined below)
to the Company or a Paying Agent, as appropriate, or (B) whose Interest Recipient Information is not duly communicated through the Participant (as defined below) and the relevant International Clearing Organization to a Paying Agent; or 

(c) to or on behalf of a Securityholder or beneficial owner of a Security who is for Japanese tax purposes treated as an individual resident
of Japan or a Japanese corporation (except for (A) a Designated Financial Institution (as defined below) who complies with the requirement to provide Interest Recipient Information or to submit a Written Application for Tax Exemption and
(B) an individual resident of Japan or a Japanese corporation who duly notifies (directly or through the Participant or otherwise) a Paying Agent of its status as not being subject to Japanese Taxes to be withheld or deducted by the Company, by
reason of such individual resident of Japan or Japanese corporation receiving interest on the relevant Security through a payment handling agent in Japan appointed by it); or 

(d) to or on behalf of a Securityholder or beneficial owner of a Security who presents a Security for payment (where presentation is required)
more than 30 days after the Relevant Date (as defined below), except to the extent that such Securityholder or beneficial owner of a Security would have been entitled to such Additional Amounts on presenting the same for payment on any date during
such 30-day period; or 

  
 14 

 (e) to or on behalf of a Securityholder who is a fiduciary or partnership or is not the sole
beneficial owner of the payment of the principal of, or any interest on, any Security, and Japanese law requires the payment to be included for tax purposes in the income of a beneficiary or settlor with respect to such fiduciary or a member of such
partnership or a beneficial owner, in each case, who would not have been entitled to such Additional Amounts had it been the holder of such Security; or 

(f) any combination of (a) through (e) above. 

Where a Security is held through a participant of a Clearing Organization or a financial intermediary (each, a
“Participant”), in order to receive payments free of withholding or deduction by the Company for, or on account of, Japanese Taxes, if the relevant beneficial owner of a Security is (1) an individual non-resident of Japan or a non-Japanese corporation that in either case is not a Specially-Related Person of the Company or (2) a Japanese financial institution (a
“Designated Financial Institution”) falling under certain categories prescribed by Article 6, Paragraph 11 of the Special Taxation Measures Act and the cabinet order thereunder (Cabinet Order No. 43 of 1957), as amended
(together with the ministerial ordinance and other regulations thereunder, the “Act”), all in accordance with the Act, such beneficial owner of a Security must, at the time of entrusting a Participant with the custody of the
relevant Security, provide certain information prescribed by the Act to enable the Participant to establish that such beneficial owner of a Security is exempted from the requirement for Japanese Taxes to be withheld or deducted (the
“Interest Recipient Information”), and advise the Participant if such beneficial owner of a Security ceases to be so exempted including the case where the relevant beneficial owner of the Security who is an individual non-resident of Japan or a non-Japanese corporation becomes a Specially-Related Person of the Company. 

Where a Security is not held by a Participant, in order to receive payments free of withholding or deduction by the Company for, or on account
of, Japanese Taxes, if the relevant beneficial owner of a Security is (i) an individual non-resident of Japan or a non-Japanese corporation that in either case is
not a Specially-Related Person of the Company or (ii) a Designated Financial Institution, all in accordance with the Act, such beneficial owner of a Security must, prior to each date on which it receives interest, submit to the Company or a
Paying Agent, as appropriate, a written application for tax exemption (hikazei tekiyo shinkokusho) (a “Written Application for Tax Exemption”) in the form obtainable from the Company or any Paying Agent, as appropriate,
stating, among other things, the name and address (and, if applicable, the Japanese individual or corporation ID number) of such beneficial owner of a Security, the title of the Securities, the relevant Interest Payment Date, the amount of interest
payable and the fact that such beneficial owner of a Security is qualified to submit the Written Application for Tax Exemption, together with documentary evidence regarding its identity and residence. 

As used herein, the “Relevant Date” means the date on which any payment in respect of a Security first becomes due, except
that, if the full amount of the moneys payable has not been duly received by the Paying Agent on or prior to such due date, it means the date on which, the full amount of such moneys having been so received, notice to that effect is duly given to
the Securityholders in accordance with the Indenture. 

  
 15 

 The obligation to pay Additional Amounts shall not apply to (i) any estate,
inheritance, gift, excise, sales, transfer, personal property or any similar tax, assessment or other governmental charge or (ii) any tax, assessment or other governmental charge that is payable otherwise than by deduction or withholding from
payments of principal or interest on the Securities; provided that, except as otherwise set forth in the Securities and the Indenture, the Company shall pay all stamp and other duties, if any, which may be imposed by Japan, the United States
or any respective political subdivision or any taxing authority thereof or therein, with respect to the Indenture or as a consequence of the issuance of the Securities. 

No Additional Amounts will be payable for or on account of any deduction or withholding imposed pursuant to Sections 1471-1474 of the U.S.
Internal Revenue Code, the U.S. Treasury regulations thereunder and any other official guidance thereunder (“FATCA”), any intergovernmental agreement entered into with respect to FATCA, or any law, regulation or other official
guidance enacted in any jurisdiction implementing, or relating to, FATCA, similar legislation under the laws of any other jurisdiction, or any such intergovernmental agreement. 

The Securities may, subject to the prior confirmation of the Financial Services Agency of Japan (if and to the extent required under the
then-applicable Japanese banking laws or regulations), be redeemed at the option of the Company in whole, but not in part, on [                ],
20[    ], at a redemption price equal to 100% of the principal amount of the Securities then outstanding plus accrued and unpaid interest to but excluding the date fixed for redemption, upon sending, or causing to be sent by
first-class mail, postage prepaid, to the Trustee and to the Holders of the Securities, notice of such redemption at not less than 15 days and not more than 60 days prior to the date fixed for redemption to such Holders of Securities at their last
addresses as they shall appear upon the registry books. The notice of redemption shall specify the election of the Company to redeem the Securities, the date fixed for redemption, the redemption price, the principal amount and CUSIP or ISIN number
and/or common code of each Security held by such Holder to be redeemed, that on the redemption date the redemption price will become due and payable upon each Security to be redeemed, that interest thereon will cease to accrue on and after the
redemption date and the place or places where the Securities to be redeemed are to be surrendered for payment of the redemption price and that (in the event the Notes are in certificated form) the Notes designated in such notice for redemption are
required to be presented on or after such redemption date at the designated place or places of payment. 
 The notice of redemption of
Securities of any series to be redeemed at the option of the Company shall be given by the Company or, at the Company’s request, by the Trustee in the name and at the expense of the Company, in which case the Company shall make such request no
later than 5 Business Days prior to the conclusion of the notice period above. 
 Any notice which is mailed in the manner as provided
herein shall be conclusively presumed to have been duly given, whether or not the Holder receives the notice. Failure to give notice by mail, or any defect in the notice, to the Holder of any Security of a series designated for redemption shall not
affect the validity of the proceedings for the redemption of any other Security of such series. 

  
 16 

 Notwithstanding any of the foregoing, the Company may give such notice in any manner
permitted or required by DTC. 
 The Securities may, subject to the prior confirmation of the Financial Services Agency of Japan (if and to
the extent required under the then-applicable Japanese banking laws or regulations), be redeemed at the option of the Company in whole, but not in part, at any time, upon not less than 30 nor more than 60 days prior notice thereof given by the
Company, at a redemption price equal to 100% of the principal amount of the Securities then outstanding (together with accrued and unpaid interest to (but excluding) the date fixed for redemption and Additional Amounts, if any), if, as a result of
any change in, or amendment to, the laws (or any regulations or rulings promulgated thereunder) of Japan (or any political subdivision or taxing authority in or of Japan) affecting taxation, or any change in the official position regarding the
application or interpretation of such laws, regulations or rulings (including a holding, judgment, or order by a court of competent jurisdiction), which change, amendment, application or interpretation becomes effective on or after
[                ], 20[    ], the Company is, or on the next Interest Payment Date would be, required to pay any Additional Amounts to holders of the
Securities, and which obligation cannot be avoided by measures reasonably available to the Company; provided that, no such notice of redemption may be given earlier than 90 days prior to the earliest date on which the Company would be
obligated to make such payment of Additional Amounts if a payment in respect of the Securities were then due. Prior to the mailing to holders of Securities of any notice of redemption of the Securities, the Company shall certify to the Trustee that
the requirements for redemption have been met and deliver therewith to the Trustee an opinion of an independent tax counsel or tax consultant of recognized standing, such opinion to be reasonably satisfactory to the Trustee, to the effect that the
circumstances referred to above exist. The Trustee shall be entitled to accept such certificate and opinion as sufficient evidence of the satisfaction of the conditions precedent described above, in which event it shall be conclusive and binding on
the Securityholders. 
 A Holder of Securities issued in definitive form may transfer or exchange Securities in accordance with the
Indenture. As described in the legend on the face of this Registered Global Security, interest payments on such Securities issued in definitive form will be subject to Japanese income taxation unless the Holder establishes the matters set forth
therein. Such legend concerning Japanese taxation shall also be included on the face of any Securities issued in definitive form. The Registrar may require a Holder, among other things, to furnish appropriate endorsements and transfer documents, and
to pay any taxes and fees required by law or permitted by the Indenture. The Company will treat the registered Holder of a Security as the owner of that Security for all purposes, except as described above. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations
of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of
the Securities at the time Outstanding of all series to be affected (voting as a class). The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the Securities of each series at the
time Outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver
by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 

  
 17 

 As provided in the Indenture and subject to certain limitations therein set forth, the
transfer of this Security is registrable, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and interest on this Security are payable, duly endorsed by, or
accompanied by a written instrument of transfer in form satisfactory to the Company and the security registrar duly executed by, the Holder hereof or his attorney duly authorized in writing and thereupon one or more new Securities of this series and
of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $200,000 and integral multiples of
$1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a
different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange; provided, however, the Company may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may deem and treat the person in whose name this Security is registered upon the Security register as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be
affected by notice to the contrary. 
 No reference herein to the Indenture and no provision of this Security or of the Indenture shall
alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

  
 18 

 This Security shall be governed by and construed in accordance with the laws of the State
of New York. 
 All capitalized terms used and not defined herein shall have the meanings assigned to them in the Indenture. 

The Company has initially appointed [                ], as
paying agent, transfer agent, registrar and calculation agent with respect to the Securities. 
 PAYING AGENT, TRANSFER AGENT, 

REGISTRAR AND CALCULATION AGENT 

[                ] 

  
 19Document

Exhibit 4.1

Description of Common Stock

    The following is a description of the general terms, provisions and rights of the common stock, par value $0.01 ("Common Stock"), of CONMED Corporation, a Delaware corporation (the "Company," "we," "us," and "our"), related provisions of the Company’s certificate of incorporation (the “Certificate of Incorporation”) and bylaws (the “Bylaws”) and applicable Delaware law. This description is qualified in its entirety by, and should be read in conjunction with, the Certificate of Incorporation and Bylaws, which have been publicly filed with the Securities and Exchange Commission, and applicable Delaware law.

Authorized Shares

    We have the authority to issue an aggregate of 100,000,000 shares of Common Stock. As of February 16, 2022, there were 31,299,194 shares of our Common Stock issued and 29,411,246 shares of our Common Stock outstanding.

Dividend Rights

    Subject to the preferences, limitations and relative rights of holders of our preferred stock, the holders of Common Stock are entitled to share ratably in dividends if, when and as declared by our board of directors out of funds legally available therefor.

Voting Rights

    Subject to the preferences, limitations and relative rights of holders of our preferred stock, the holders of Common Stock are entitled to one vote for each share held of record on all matters at all meetings of stockholders.

Liquidation Rights

    Subject to the preferences, limitations and relative rights of holders of our preferred stock, the holders of Common Stock are entitled, in the event of our liquidation, dissolution or winding-up, to share ratably in the distribution of assets remaining after payment of debts and expenses.

Absence of Other Rights

    Our Common Stock has no sinking fund or redemption provisions or preemptive, conversion or exchange rights.

Anti-Takeover Effects of Our Certificate of Incorporation and Bylaws

    Our Certificate of Incorporation and Bylaws contain provisions that may delay, defer or discourage another party from acquiring control of us. We expect that these provisions, some of which are summarized below, will discourage coercive takeover practices or inadequate takeover bids. These provisions are also designed to encourage persons seeking to acquire control of us to first negotiate with the board of directors, which we believe may result in an improvement of the terms of any such acquisition in favor of our stockholders. However, they also give the board of directors the power to discourage acquisitions that some stockholders may favor.

Special Meetings of Stockholders

    Our Bylaws provide that special meetings of stockholders may be called by the board of directors, the chair of the board of directors, if any, the lead independent director of the board of directors, if any, or the president, or upon the request of stockholders holding at least 25% of the Company's outstanding stock entitled to vote, subject to certain procedural and informational requirements for calling special meetings of stockholders set forth in the Bylaws.

Stockholder Action by Written Consent

Our Certificate of Incorporation provides that stockholders can take action by written consent if stockholders holding not less than the minimum number of votes required to authorize or take such action consent, subject to certain procedural safeguards set forth in the Certificate of Incorporation, including a requirement that the holders of at least 25% of the 

Company’s outstanding Common Stock (provided that such shares are determined to be Net Long Shares (as defined in the Bylaws) that have been held continuously for at least one year) request that the Board set a record date to determine the stockholders entitled to act by written consent.

Advance Notice Requirements for Stockholder Proposals and Director Nominations

    Our Bylaws require compliance with advance notice procedures for stockholder proposals and director  nominations to be brought before an annual meeting of the stockholders.

Exclusive Forum

Our Bylaws provide that unless the Company consents in writing to the selection of an alternate forum, (a) the Court of Chancery of the State of Delaware will be the sole and exclusive forum for (i) any derivative action or proceeding brought on our behalf; (ii) any action asserting a breach of fiduciary duty owed by any of our directors, officers, employees, or stockholders to the Company or our stockholders; (iii) any action asserting a claim arising pursuant to the Delaware General Corporation Law (the “DGCL”), our Certificate of Incorporation or our Bylaws; (iv) any action to interpret, apply, enforce or determine the validity of our Certificate of Incorporation or our Bylaws; or (v) any action asserting a claim against us that is governed by the internal affairs doctrine (or, if the Court of Chancery does not have jurisdiction, then the Superior Court of the State of Delaware, or if no state court in Delaware has jurisdiction, the federal district court for the District of Delaware); and (b) the federal district courts of the United States shall be the exclusive forum for the resolution of any complaint asserting a cause of action arising under the Securities Act of 1933, as amended.

Amendment to Certificate of Incorporation and Bylaws

    Delaware law provides generally that a majority vote of all the outstanding shares entitled to vote thereon at a meeting of stockholders is required to approve amendments to a corporation’s certificate of incorporation, unless a corporation’s certificate of incorporation requires a greater percentage. 

Delaware law provides generally that by-laws may be amended, adopted or repealed by the vote of a majority of the shares cast at a meeting of the Company’s stockholders, unless the certificate of incorporation or by-laws provide otherwise.  Our Bylaws provide that they may be amended, altered or repealed by a majority vote of the outstanding shares of the Company entitled to vote thereon.  Additionally, if permitted under the corporation’s certificate of incorporation, under Delaware law the board of directors may also amend, adopt or repeal the Company’s by-laws. Our Certificate of Incorporation provides that the Bylaws may be amended, altered, or repealed by our board of directors without stockholder approval; provided, however, that any by-law adopted by the board of directors may be amended or repealed by our stockholders.

Delaware Anti-Takeover Statute

    We are subject to Section 203 of the DGCL. Accordingly, we may not engage in a business combination, such as a merger, consolidation, recapitalization, asset sale or disposition of stock, with any “interested stockholder” for a period of three years from the date that the interested stockholder first became an interested stockholder unless certain conditions are met.

Indemnification and Limitations on Liability of Officers and Directors

Our Certificate of Incorporation and Bylaws require the indemnification of directors and officers by the Company to the fullest extent permitted by law, but our Bylaws provide that no indemnification is required with respect to any settlement or disposition of a proceeding unless the Company has given its prior consent to such settlement/disposition. Our Bylaws also permit us to indemnify employees and to advance expenses to any person entitled to indemnification upon request.

Section 102(b)(7) of the DGCL permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, except for liability for (i) any breach of the director’s duty of loyalty to the corporation or its stockholders, (ii) acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) payments of unlawful dividends or unlawful stock purchases or redemptions, or (iv) any transaction from which the director derived an improper personal benefit. Our Certificate of Incorporation contains a provision eliminating the personal liability of directors for monetary damages to the fullest extent permitted by law.

Listing

The Company's Common Stock is listed on the New York Stock Exchange under the trading symbol "CNMD." 

Transfer Agent and Registrar

The transfer agent and registrar for our Common Stock is Computershare Investor Services.

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