Document:

EX-10.52

 Exhibit 10.52 

CHANGE OF CONTROL AGREEMENT 

This CHANGE OF CONTROL AGREEMENT (this “Agreement”) dated as of the 11th day of
December, 2012 is by and between CRYOLIFE, INC., a Florida corporation (“CryoLife” or the “Company”) and David C. Gale, Ph.D. (the “Officer”). 

W I T N E S S E T H: 

WHEREAS, the Board of Directors of the Company upon the recommendation of the Compensation Committee, has determined that it is in the best
interests of the Company and its shareholders to enter into this Change of Control Agreement in order to assure that the Company will have the continued dedication of Officer, notwithstanding the possibility, threat or occurrence of a Change of
Control (as defined herein) of the Company; and 
 WHEREAS, Officer has determined that it is in the best interests of Officer to enter into
this Agreement; 
 NOW, THEREFORE, in consideration of the premises, the promises hereinafter set forth and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged by both parties, it is hereby agreed as follows: 
  

	 	1.	CERTAIN DEFINITIONS. 

 (a) “Effective Date” means the first date during
the Change of Control Period (as defined herein) on which a Change of Control occurs. Notwithstanding anything in this Agreement to the contrary, if the Officer’s employment with the Company is Terminated by the Company without Cause or by
Officer for Good Reason (as such terms are defined herein) within the six (6) month period prior to the date on which the Change of Control occurs and if such Change of Control is consummated (such a Termination of employment, an
“Anticipatory Termination”), then for all purposes of this Agreement the “Effective Date” means the date immediately prior to the date of such Termination of employment. 

(b) “Change of Control Period” means the period commencing on the date hereof and ending on September 1, 2014;
provided, however, that, commencing on September 1, 2014, and each three-year anniversary of such date (such date and each such three-year anniversary thereof, the “Renewal Date”) unless previously terminated, the Change
of Control Period shall be automatically extended so as to terminate three (3) years from such Renewal Date, unless, at least thirty (30) days prior to the next Renewal Date, the Company shall give notice to the Officer that the Change of
Control Period shall not be so extended. 
 (c) “Affiliated Company” means any company controlled by, controlling or under
common control with the Company. 
 (d) “Change of Control” means a change in the ownership or effective control of, or in
the ownership of a substantial portion of the assets of, the Company, as described in paragraphs (i) through (iii) below. 

 (i) Change in Ownership of the Company. A change in the ownership of the Company shall
occur on the date that any one person, or more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is a member, acquires ownership of the Company stock that, together with the Company stock
held by such person or group, constitutes more than 50% of the total voting power of the stock of the Company. 
 (A) If any one person or
more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is a member, is considered to own more than 50% of the total voting power of the stock of the Company, the acquisition of additional
the Company stock by such person or persons shall not be considered to cause a change in the ownership of the Company or to cause a change in the effective control of the Company (within the meaning of paragraph (ii) below). 

(B) An increase in the percentage of the Company stock owned by any one person, or persons acting as a group (within the meaning of paragraph
(iv)), as a result of a transaction in which the Company acquires its stock in exchange for property, shall be treated as an acquisition of stock for purposes of this paragraph (i). 

(C) Except as provided in (B) above, the provisions of this paragraph (i) shall apply only to the transfer or issuance of the
Company stock if such stock remains outstanding after such transfer or issuance. 
 (ii) Change in Effective Control of the Company.

 (A) A change in the effective control of the Company shall occur on the date that either of (1) or (2) below occurs: 

(1) Any one person, or more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is
a member, acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such person or persons) ownership of stock of the Company possessing 30% or more of the total voting power of the stock
of the Company; or 
 (2) A majority of the members of the Company Board of Directors are replaced during any twelve (12) month period
by Directors whose appointment or election is not endorsed by a majority of the Board of Directors prior to the date of the appointment or election. 

(B) A change in effective control of the Company also may occur with respect to any transaction in which either of the Company or the other
entity involved in a transaction experiences a Change of Control event described in paragraphs (i) or (iii). 
 (C) If any one person,
or more than one person acting as a group (within the meaning of paragraph (iv)), is considered to effectively control the Company (within the meaning of this paragraph (ii)), the acquisition of additional control of the Company by the same person
or persons shall not be considered to cause a change in the effective control of the Company (or to cause a change in the ownership of the Company within the meaning of paragraph (i)). 

 (iii) Change in Ownership of a Substantial Portion of the Company’s Assets. A change
in the ownership of a substantial portion of the Company’s assets shall occur on the date that any one person, or more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is a member,
acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value (within the meaning of paragraph
(iii)(B)) equal to or more than 40% of the total gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions. 

(A) A transfer of the Company’s assets shall not be treated as a change in the ownership of such assets if the assets are transferred to
one or more of the following: 
 (1) A shareholder of the Company (immediately before the asset transfer) in exchange for or with respect
to the Company stock; 
 (2) An entity, 50% or more of the total value or voting power of which is owned, directly or indirectly, by the
Company; 
 (3) A person, or more than one person acting as a group (within the meaning of paragraph (iv)) that owns, directly or
indirectly, 50% or more of the total value or voting power of all of the outstanding stock of the Company; or 
 (4) An entity, at least
50% of the total value or voting power of which is owned, directly or indirectly, by a person described in paragraph (iii)(A)(3). 
 For
purposes of this paragraph (iii)(A), and except as otherwise provided, a person’s status is determined immediately after the transfer of assets. 

(B) For purposes of this paragraph (iii), gross fair market value means the value of all the Company assets, or the value of the assets being
disposed of, determined without regard to any liabilities associated with such assets. 
 (iv) For purposes of this Section 1(d),
persons shall be considered to be acting as a group if they are owners of an entity that enters into a merger, consolidation, purchase, or acquisition of assets, or similar business transaction with the Company. If a person, including an entity
shareholder, owns stock in the Company and another entity with which the Company enters into a merger, consolidation, purchase, or acquisition of stock, or similar business transaction, such shareholder shall be considered to be acting as a group
with the other shareholders in a corporation only to the extent of the ownership in that corporation prior to the transaction giving rise to the change and not with respect to the ownership interest in the other corporation. Persons shall not be
considered to be acting as a group solely because they purchase or own stock of the Company at the same time, or as a result of the same public offering of the Company’s stock. 

(e) Terminate or Termination means a “separation from service” within the meaning of Section 409A of the Internal
Revenue Code of 1986, as amended. 

	 	2.	EMPLOYMENT. 

 Officer and the Company acknowledge that the employment of the Officer by
the Company is “at will” and Officer shall have no rights under this Agreement unless Officer is Terminated by the Company without Cause or by the Officer with Good Reason during the period commencing on the Effective Date and ending on
the second anniversary of such date. 
  

	 	3.	TERMS OF AT WILL EMPLOYMENT. 

 (a) During the term of his or her employment by the
Company, and excluding any periods of vacation and sick leave to which the Officer is entitled, the Officer agrees to devote reasonable attention and time to the business and affairs of the Company and, to the extent necessary to discharge the
responsibilities assigned to the Officer by the Board of Directors or the Chief Executive Officer, to use the Officer’s reasonable best efforts to perform faithfully and efficiently such responsibilities. 

(b) During the term of this Agreement, the Officer will not, without the prior written consent of the Company, directly or indirectly other
than in the performance of the duties hereunder, render services of a business, professional or commercial nature to any other person or firm, whether for compensation or otherwise, except: (i) with respect to any noncompetitive family
businesses of the Officer for which the rendering of such services will not have an adverse effect upon Officer’s performance of his duties and obligations hereunder; (ii) that Officer shall be permitted to engage in charitable and
community affairs provided that such activities do not interfere with the performance of his duties and responsibilities enumerated herein; and (iii) to give attention to Officer’s investments provided that such activities do not interfere
with the performance of his duties and responsibilities enumerated herein. 
  

	 	4.	TERMINATION OF EMPLOYMENT. 

 (a) Cause. For purposes of this Agreement,
“Cause” shall mean: 
 (i) an intentional act of fraud, embezzlement, theft or any other material violation of law that occurs
during or in the course of the Officer’s employment with the Company; 
 (ii) intentional damage by Officer to the Company’s
assets; 
 (iii) intentional disclosure by Officer of the Company’s confidential information contrary to the Company policies; 

(iv) material breach of the Officer’s obligations under this Agreement; 

(v) intentional engagement by the Officer in any activity which would constitute a breach of the Officer’s duty of loyalty or of the
Officer’s assigned duties; 
 (vi) intentional breach by the Officer of any of the Company’s policies and procedures; 

 (vii) the willful and continued failure by Officer to perform the Officer’s assigned duties
(other than as a result of incapacity due to physical or mental illness); or 
 (viii) willful conduct by the Officer that is demonstrably
and materially injurious to the Company, monetarily or otherwise. 
 (b) Good Reason. For purposes of this Agreement, “Good
Reason” shall mean the assignment to the Officer, without the Officer’s consent, of any duties materially inconsistent with the Officer’s position (including changes in status, offices, or titles and any change in the Officer’s
reporting requirements that would cause Officer to report to an officer who is junior in seniority to the officer to whom Officer reports), authority, duties or responsibilities, determined as of the later of the date of this Agreement or the date
of any modification to Officer’s position (including status, offices, titles and reporting requirements, as described above), authority, duties or responsibilities that is agreed to by Officer, or any other action by the Company that results in
a material diminution in such position, authority, duties, responsibilities or Officer’s aggregate compensation, excluding for this purpose an isolated, insubstantial and inadvertent action taken in good faith and which is remedied by the
Company within thirty (30) days after receipt of notice thereof given by the Officer (each of these an “Event” for purposes of this Section 4(b)). Officer must notify the Company of any Event that constitutes Good Reason within
ninety (90) days following Officer’s knowledge of the existence of such Event or such Event shall not constitute Good Reason under this Agreement. 

(c) Notice of Termination. Any Termination by the Company for Cause, or by the Officer for Good Reason, shall be communicated by Notice
of Termination to the other party hereto given in accordance with Section 11(b) of this Agreement. For purposes of this Agreement, a “Notice of Termination” means a written notice which (i) indicates the specific termination
provision in this Agreement relied upon, (ii) to the extent applicable, sets forth in reasonable detail the facts and circumstances claimed to provide a basis for termination of the Officer’s employment under the provision so indicated and
(iii) specifies the termination date (which date shall not be more than thirty (30) days after the giving of such notice; provided, however, if Officer is terminating for Good Reason such date shall not be less than thirty
(30) nor more than forty-five (45) days after giving of such notice). The failure by the Officer or the Company to set forth in the Notice of Termination any fact or circumstance which contributes to a showing of Good Reason or Cause shall
not waive any right of the Officer or the Company, respectively, hereunder or preclude the Officer or the Company, respectively, from asserting such fact or circumstance in enforcing the Officer’s or the Company’s rights hereunder. 

(e) Date of Termination. “Date of Termination” means the date of receipt of the Notice of Termination, or any later date
specified therein, as the case may be. The Company and the Officer shall take all steps necessary (including with regard to any post-Termination services by the Officer) to ensure that any Termination described in this Section 4 constitutes a
“separation from service” within the meaning of Section 409A of the Code, and notwithstanding anything contained herein to the contrary, the date on which the separation from service takes place shall be the “Date of
Termination.” 

 (f) Covenants Necessary to the Company’s Business. 

(i) Non-Solicitation of Customers. The Officer covenants and agrees that, during the term of this Agreement and for a period of one
(1) year following the termination of this Agreement Officer will not, either directly or indirectly, in competition with the Company Business (as defined below), solicit, entice or recruit for a Competing Business (as defined below), attempt
to solicit, entice or recruit for a Competing Business, or attempt to divert or appropriate to a Competing Business, any actual or prospective customer of the Company with whom Officer had contact on behalf of the Company. For the purposes of this
Agreement, “Company Business” shall mean the business of (A) processing cardiac or vascular tissues, (B) marketing biological glue or protein hydrogel technology products, (C) marketing transport or other solutions for use
with human organs to be transplanted and/or (D) marketing hemostatic agents for use in surgeries. “Competing Business” shall mean any person or entity that engages in a commercial business that is the same as or substantially similar
to the Company Business, and only that portion of the business that is in competition with the Company Business. 
 (ii)
Non-Solicitation of Employees. Officer covenants and agrees that, during the term of this Agreement for a period of one (1) year following the Date of Termination, Officer will not, either directly or indirectly, solicit, entice,
encourage, cause, or recruit any person employed by the Company and with whom Officer had contact during Officer’s employment with the Company to leave such person’s employment with the Company to join a Competing Business. 

(iii) Consideration for Covenants. Officer covenants and agrees that the payment of any Severance Payment (as defined in
Section 5(e)) shall be subject to and expressly conditioned upon Officer’s compliance with the covenants set forth in subparagraphs (i) and (ii) above. Should Officer fail to comply with these covenants, the Company shall not be
required to make the Severance Payment (or any portion of the Severance Payment that remains unpaid), and the Officer shall be required to repay any portion of the Severance Payment that the Officer has already received from the Company. 

 

	 	5.	OBLIGATIONS OF THE COMPANY UPON TERMINATION. 

 (a) If, during the two (2) year
period commencing on the Effective Date and ending on the second anniversary of the Effective Date, (i) the Company shall Terminate the Officer’s employment without Cause, or (ii) the Officer shall Terminate employment for Good
Reason, then the Company shall pay to Officer the Severance Payment (defined below). 
 (b) Severance Payment. The “Severance
Payment” shall be an amount equal to one (1) times the aggregate of Officer’s base salary as of the Date of Termination and bonus compensation for the year in which the Termination of employment occurs. For purposes of determining
Officer’s bonus compensation for purposes of this Section 5(b), if the Date of Termination occurs before the awarding of bonuses for the year in which the Date of Termination occurs, the bonus compensation component of the Severance
Payment shall be computed based on Officer’s most recent awarded bonus. Bonus compensation shall include both the Annual Bonus paid in cash and the value of any non-cash bonuses, such as options or restricted stock. Any such options will be
valued pursuant to the Black Scholes valuation method as of the grant date, using the same 

 
assumptions used by the Company in computing the FAS 123R charge for the options, and any shares of restricted stock will be valued at the closing price of the Company Common Stock on The New
York Stock Exchange on the date of issuance. The Company’s annual option and restricted stock grants shall not be deemed to be bonus compensation unless they are specifically designated as such by the Company Compensation Committee. For the
sake of clarification, all cash paid and any shares issued in payment of all or a portion of the bonus pursuant to the Company’s Officer Incentive Plan shall be bonus compensation for purposes of this Agreement for the year in which paid or
issued. The Severance Payment shall be payable to Officer as follows: 
 (i) The Severance Payment, if any is due hereunder, shall be paid
to Officer in a lump sum not later than thirty (30) days following Officer’s Date of Termination. 
 (ii) In the event of an
Anticipatory Termination, the Severance Payment shall be paid to Officer in a lump sum not later than thirty (30) days following the date of the Change of Control. 

Notwithstanding the foregoing, if any amount paid pursuant to this Section 5(b) is deferred compensation within the meaning of Section 409A of the
Code and as of the Date of Termination Officer is a Specified Employee, amounts that would otherwise be payable during the six-month period immediately following the Date of Termination shall instead be paid, with interest on any delayed payment at
the applicable federal rate provided for in Section 7872(f)(2)(A) of the Code, on the first business day after the date that is six months following Officer’s “separation from service” within the meaning of Section 409A of
the Code (the “Delayed Payment Date”). As used in this Agreement, the term “Specified Employee” means a “specified employee” as defined in Section 409A(a)(2)(B)(i) of the Internal Revenue Code of 1986, as amended
(the “Code”). By way of clarification, “specified employee” means a “key employee” (as defined in Section 416(i) of the Code, disregarding Section 416(i)(5) of the Code) of the Company. Officer shall be
treated as a key employee if the Officer meets the requirement of Section 416(i)(1)(A)(i), (ii), or at any time during the twelve (12) month period ending on an “identification date”. For purposes of any “Specified
Employee” determination hereunder, the “identification date” shall mean the last day of each calendar year. 
  

	 	6.	FULL SETTLEMENT. 

 In no event shall the Officer be obligated to seek other
employment or take any other action by way of mitigation of the amounts payable to the Officer under any of the provisions of this Agreement and such amounts shall not be reduced whether or not the Officer obtains other employment. The Company
agrees to pay, to the full extent permitted by law, all legal fees and expenses which the Officer may reasonably incur as a result of any contest by the Company or Officer with respect to liability under or the interpretation of the validity or
enforceability of, any provision of this Agreement, but only in the event and to the extent that (i) the Officer receives a final, non-appealable judgment in his favor in any such action or receives a final judgment in his favor that has not
been appealed by the Company within thirty (30) days of the date of the judgment; or (ii) the parties agree to dismiss any such action upon the Company’s payment of the sums allegedly due the Officer or performance of the covenants by
the Company allegedly breached by it. 

	 	7.	PAYMENT CUT-BACK. 

 (a) Notwithstanding anything to the contrary contained herein,
the Company will not pay to Officer any excise tax gross up pursuant to this Agreement or any other agreement between Officer and the Company. Further notwithstanding anything to the contrary contained herein, the Company shall reduce any payment
contingent on a Change of Control pursuant to any plan, agreement, or arrangement of the Company that would be considered in determining whether a “parachute payment” (as defined in Section 280G (“Section 280G”) of the
Code), has occurred (“Change of Control Severance Payment”) to 2.99 times Employee’s average compensation, as indicated on such Employee’s Form W-2, for the five (5) years ending immediately prior to the year containing the
date of the Change of Control (the “Safe Harbor Amount”) if, and only if, reducing the Change of Control Severance Payment would provide Officer with a greater net after-tax Change of Control Severance Payment than would be the case if no
such reduction took place. The Safe Harbor Amount, as defined herein, is an amount expressed in present value which maximizes the aggregate present value of the Change of Control Severance Payment without causing the Change of Control Severance
Payment to be subject to the excise tax under Section 4999 (and related Section 280G) of the Code (the “Excise Tax”), determined in accordance with Section 280G(d)(4). Any reduction in the Change of Control Severance Payment
shall be implemented in accordance with Section 7(b). 
 (i) Any reduction in payments pursuant to Section 7(a) shall apply to
cash payments and/or vesting of equity awards so as to minimize the amount of compensation that is reduced (i.e., it applies to payments or vesting that to the greatest extent represent parachute payments), with the amount of compensation based on
vesting to be based on all facts and circumstances as of the date of such vesting; provided, however, the reduction shall first be applied to cash payments and only applied to equity awards thereafter, such that equity awards are only reduced to the
extent absolutely necessary; further, provided, however, no reduction shall be applied to an amount that constitutes a deferral of compensation under Section 409A except for amounts that have become payable at the time of the reduction and as
to which the reduction will not result in a non-reduction in a corresponding amount that is a deferral of compensation under Section 409A that is not currently payable. 

(ii) For purposes of determining whether the Change of Control Severance Payment will be subject to the Excise Tax and the amount of such
Excise Tax: 
 (A) The Change of Control Severance Payment shall be treated as a “parachute payment” within the meaning of
Section 280G(b)(2), and if it is an “excess parachute payment” within the meaning of Section 280G(b)(1), it shall be treated as subject to the Excise Tax, unless, and except to the extent that, in the written opinion of independent
compensation payment” within the meaning of Section 280G(b)(1), it shall be treated as subject to the Excise Tax, unless, and except to the extent that, in the written opinion of independent compensation consultants, counsel or auditors of
nationally recognized standing (“Independent Advisors”) selected by the Company and reasonably acceptable to Officer, the Change of Control Severance Payment (in whole or in part) does not constitute a parachute payment, or such excess
parachute payment (in whole or in part) represents reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) in excess of the base amount within the meaning of Section 280G(b)(3) or are otherwise not subject to
the Excise Tax. 

 (B) The value of any non-cash benefits or any deferred payment or benefit shall be determined by
the Independent Advisors in accordance with the principles of Sections 280G(d)(3) and (4). 
 (iii) For purposes of determining reductions
in compensation pursuant to this Section 7(b), if any, Officer will be deemed (A) to pay federal income taxes at the applicable rates of federal income taxation for the calendar year in which the compensation would be payable; and
(B) to pay any applicable state and local income taxes at the applicable rates of taxation for the calendar year in which the compensation would be payable, taking into account any effect on federal income taxes from payment of state and local
income taxes. Compensation will be adjusted not later than the applicable deadline under Section 409A to provide for accurate payments under the cut-back provision of this Section 7(b), but after any such deadline no further adjustment
will be made if it would result in a tax penalty under Section 409A. 
 (b) Furthermore, notwithstanding anything in this Agreement to
the contrary notwithstanding, aggregate severance, separation and/or similar payments made to Officer pursuant to this Agreement and otherwise shall be limited to the equivalent of Officer’s salary paid during the three (3) completed
fiscal years ended prior to the Date of Termination, including bonuses and guaranteed benefits paid during those years. 
  

	 	8.	CONFIDENTIAL INFORMATION. 

 The Officer and the Company are parties to one or more
separate agreements respecting confidential information, trade secrets, inventions and non-competition (collectively, the “IP Agreements”). The parties agree that the IP Agreements shall not be superseded or terminated by this Agreement
and shall survive any termination of this Agreement; provided, however, that to the extent that there is any conflict or overlap between the provisions of this Agreement and any of the IP Agreements, those provisions that provide the Company with
the greatest rights and protections shall control. 
  

	 	9.	SUCCESSORS. 

 (a) This Agreement is personal to the Officer and without the prior written
consent of the Company shall not be assignable by the Officer otherwise than by will or the laws of descent and distribution. This Agreement shall inure to the benefit of and be enforceable by the Officer’s legal representatives. 

(b) This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns. 

(c) The Company will require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or
substantially all of the business and/or assets of the Company to assume expressly and agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform it if no such succession had taken

 
place. As used in this Agreement, “the Company” shall mean CryoLife as hereinbefore defined and any successor to its business and/or assets as aforesaid which assumes and agrees to
perform this Agreement by operation of law, or otherwise. 
  

	 	10.	COMPLIANCE WITH SECTION 409A. 

 (a) This Agreement is intended to comply with, or
otherwise be exempt from, Section 409A of the Code and any regulations and Treasury guidance promulgated thereunder. 
 (b) The Company
and Officer agree that they will execute any and all amendments to this Agreement as they mutually agree in good faith may be necessary to ensure compliance with Section 409A of the Code. 

(c) The Company makes no representation or warranty as to the tax effect of any of the preceding provisions, and the provisions of this
Agreement shall not be construed as a guarantee by the Company of any particular tax effect to Officer under this Agreement. the Company shall not be liable to Officer or any other person for any payment made under this Agreement which is determined
to result in the imposition of an excise tax, penalty or interest under Section 409A of the Code, nor for reporting in good faith any payment made under this Agreement as an amount includible in gross income under Section 409A of the Code.

  

	 	11.	MISCELLANEOUS. 

 (a) This Agreement shall be governed by and construed in accordance with
the laws of the State of Georgia, without reference to principles of conflict of laws. The captions of this Agreement are not part of the provisions hereof and shall have no force and effect. This Agreement may not be amended or modified otherwise
than by a written agreement executed by the parties hereto or their respective successors and legal representatives. 
 (b) All notices and
other communications hereunder shall be in writing and shall be given by hand delivery (which shall include delivery via Federal Express or UPS) to the other party or by registered or certified mail, return receipt requested, postage prepaid,
addressed as follows: 
 If to the Officer: 

David C. Gale, Ph.D. 
 962
Kinghorn Drive, N.W. 
 Kennesaw, GA 30152 

If to the Company: 
 CryoLife,
Inc. 
 1655 Roberts Boulevard, N.W, 

Kennesaw, Georgia 30144 

Attention: Chief Executive Officer 

 or to such other address as either party shall have furnished to the other in writing in accordance herewith.
Notice and communications shall be effective when actually received by the addressee. 
 (c) If any provision of this Agreement or the
application of any provision hereof to any person or circumstance is held invalid, unenforceable or otherwise illegal, the remainder of this Agreement and the application of such provision to any other person or circumstance shall not be affected,
and the provision so held to be invalid, unenforceable or otherwise illegal shall be reformed to the extent (and only to the extent) necessary to make it valid, enforceable and legal; provided, however, if the provision so held to be invalid,
unenforceable or otherwise illegal cannot be reformed so as to be valid and enforceable, then it shall be severed from, and shall not affect the enforceability of, the remaining provisions of the Agreement. 

(d) The Company may withhold from any amounts payable under this Agreement such Federal, state, local or foreign taxes as shall be required to
be withheld pursuant to any applicable law or regulation. 
 (e) This Agreement supersedes that certain Change of Control Agreement dated
February 15, 2012 by and between the Company and the Officer and embodies the entire agreement between the parties with respect to the subject matter addressed herein, except as specifically set forth in Section 9 above. From and after the
Effective Date, this Agreement shall supersede any other agreement between the parties with respect to the subject matter hereof. Officer acknowledges that he has been offered reimbursement for certain estate planning services as consideration for
entering into this Agreement, as previously disclosed to Officer. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written. 
  

			
	 /s/ David C. Gale, Ph.D.

	David C. Gale, Ph.D.
	
	CRYOLIFE, INC.
		
	By:	 	 Steven G. Anderson

		 	Steven G. Anderson
		 	Chairman, President and CEOEX-10.53

 Exhibit 10.53 

CHANGE OF CONTROL AGREEMENT 

This CHANGE OF CONTROL AGREEMENT (this “Agreement”) dated as of the 1st day of April, 2015 is by and between CRYOLIFE, INC., a
Florida corporation (“CryoLife” or the “Company”) and Jean F. Holloway (the “Officer”). 
 W I
T N E S S E T H: 
 WHEREAS, the Board of Directors of the Company, upon the
recommendation of the Compensation Committee, has determined that it is in the best interests of the Company and its shareholders to enter into this Change of Control Agreement in order to assure that the Company will have the continued dedication
of Officer, notwithstanding the possibility, threat or occurrence of a Change of Control (as defined herein) of the Company; and 
 WHEREAS,
Officer has determined that it is in the best interests of Officer to enter into this Agreement; 
 NOW, THEREFORE, in consideration of the
premises, the promises hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged by both parties, it is hereby agreed as follows: 

 

	 	1.	CERTAIN DEFINITIONS. 

 (a) “Effective Date” means the first date during
the Change of Control Period (as defined herein) on which a Change of Control occurs. Notwithstanding anything in this Agreement to the contrary, if the Officer’s employment with the Company is Terminated by the Company without Cause or by
Officer for Good Reason (as such terms are defined herein) within the six (6) month period prior to the date on which the Change of Control occurs and if such Change of Control is consummated (such a Termination of employment, an
“Anticipatory Termination”), then for all purposes of this Agreement the “Effective Date” means the date immediately prior to the date of such Termination of employment. 

(b) “Change of Control Period” means the period commencing on the date hereof and ending on September 1, 2017;
provided, however, that, commencing on September 1, 2017, and each three-year anniversary of such date (such date and each such three-year anniversary thereof, the “Renewal Date”) unless previously terminated, the Change
of Control Period shall be automatically extended so as to terminate three (3) years from such Renewal Date, unless, at least thirty (30) days prior to the next Renewal Date, the Company shall give notice to the Officer that the Change of
Control Period shall not be so extended. 
 (c) “Affiliated Company” means any company controlled by, controlling or under
common control with the Company. 
 (d) “Change of Control” means a change in the ownership or effective control of, or in
the ownership of a substantial portion of the assets of, the Company, as described in paragraphs (i) through (iii) below. 
 (i)
Change in Ownership of the Company. A change in the ownership of the Company shall occur on the date that any one person, or more than one person acting as a group 

 
(within the meaning of paragraph (iv)), other than a group of which Officer is a member, acquires ownership of the Company stock that, together with the Company stock held by such person or
group, constitutes more than 50% of the total voting power of the stock of the Company. 
 (A) If any one person or more than one person
acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is a member, is considered to own more than 50% of the total voting power of the stock of the Company, the acquisition of additional the Company stock by
such person or persons shall not be considered to cause a change in the ownership of the Company or to cause a change in the effective control of the Company (within the meaning of paragraph (ii) below). 

(B) An increase in the percentage of the Company stock owned by any one person, or persons acting as a group (within the meaning of paragraph
(iv)), as a result of a transaction in which the Company acquires its stock in exchange for property, shall be treated as an acquisition of stock for purposes of this paragraph (i). 

(C) Except as provided in (B) above, the provisions of this paragraph (i) shall apply only to the transfer or issuance of the
Company stock if such stock remains outstanding after such transfer or issuance. 
 (ii) Change in Effective Control of the Company.

 (A) A change in the effective control of the Company shall occur on the date that either of (1) or (2) below occurs: 

(1) Any one person, or more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is
a member, acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such person or persons) ownership of stock of the Company possessing 30% or more of the total voting power of the stock
of the Company (the provisions of Sections 1(d)(i) (B) and (C) above shall apply equally to this Section 1(d)(ii)(A)(1); or 

(2) A majority of the members of the Company Board of Directors are replaced during any twelve (12) month period by Directors whose
appointment or election is not endorsed by a majority of the Board of Directors prior to the date of the appointment or election. 
 (B) A
change in effective control of the Company also may occur with respect to any transaction in which either of the Company or the other entity involved in a transaction described in paragraph (iii) experiences a Change of Control event described
in paragraphs (i) or (iii). 
 (C) If any one person, or more than one person acting as a group (within the meaning of paragraph
(iv)), is considered to effectively control the Company (within the meaning of this paragraph (ii)), the acquisition of additional control of the Company by the same person or persons shall not be considered to cause a change in the effective
control of the Company (or to cause a change in the ownership of the Company within the meaning of paragraph (i)). 

 (iii) Change in Ownership of a Substantial Portion of the Company’s Assets. A change
in the ownership of a substantial portion of the Company’s assets shall occur on the date that any one person, or more than one person acting as a group (within the meaning of paragraph (iv)), other than a group of which Officer is a member,
acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value (within the meaning of paragraph
(iii)(B)) equal to or more than 40% of the total gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions. 

(A) A transfer of the Company’s assets shall not be treated as a change in the ownership of such assets if the assets are transferred to
one or more of the following: 
 (1) A shareholder of the Company (immediately before the asset transfer) in exchange for or with respect
to Company stock; 
 (2) An entity, 50% or more of the total value or voting power of which is owned, directly or indirectly, by the
Company; 
 (3) A person, or more than one person acting as a group (within the meaning of paragraph (iv)) that owns, directly or
indirectly, 50% or more of the total value or voting power of all of the outstanding stock of the Company; or 
 (4) An entity, at least
50% of the total value or voting power of which is owned, directly or indirectly, by a person described in paragraph (iii)(A)(3). 
 For
purposes of this paragraph (iii)(A), and except as otherwise provided herein, a person’s status is determined immediately after the transfer of assets. 

(B) For purposes of this paragraph (iii), gross fair market value means the value of all the Company assets, or the value of the assets being
disposed of, determined without regard to any liabilities associated with such assets. 
 (iv) For purposes of this Section 1(d),
persons shall be considered to be acting as a group if they are owners of an entity that enters into a merger, consolidation, purchase, or acquisition of assets, or similar business transaction with the Company. If a person, including an entity
shareholder, owns stock in the Company and another entity with which the Company enters into a merger, consolidation, purchase, or acquisition of stock, or similar business transaction, such shareholder shall be considered to be acting as a group
with the other shareholders in a corporation only to the extent of the ownership in that corporation prior to the transaction giving rise to the change and not with respect to the ownership interest in the other corporation. Persons shall not be
considered to be acting as a group solely because they purchase or own stock of the Company at the same time, or as a result of the same public offering of the Company’s stock. 

(e) Terminate or Termination means a “separation from service” within the meaning of Section 409A of the Internal Revenue Code
of 1986, as amended. 

	 	2.	EMPLOYMENT. 

 Officer and the Company acknowledge that the employment of the Officer by
the Company is “at will,” and Officer shall have no rights under this Agreement unless Officer is Terminated by the Company without Cause or by the Officer with Good Reason during the period commencing on the Effective Date and ending on
the second anniversary of such date. 
  

	 	3.	TERMS OF AT WILL EMPLOYMENT. 

 (a) During the term of his or her employment by the
Company, and excluding any periods of vacation and sick leave to which the Officer is entitled, the Officer agrees to devote reasonable attention and time to the business and affairs of the Company and, to the extent necessary to discharge the
responsibilities assigned to the Officer by the Board of Directors or the Chief Executive Officer, to use the Officer’s reasonable best efforts to perform faithfully and efficiently such responsibilities. 

(b) During the term of this Agreement, the Officer will not, without the prior written consent of the Company, directly or indirectly, other
than in the performance of the duties hereunder, render services of a business, professional or commercial nature to any other person or firm, whether for compensation or otherwise, except: (i) with respect to any noncompetitive family
businesses of the Officer for which the rendering of such services will not have an adverse effect upon Officer’s performance of his duties and obligations hereunder; (ii) that Officer shall be permitted to engage in charitable and
community affairs provided that such activities do not interfere with the performance of his duties and responsibilities enumerated herein; and (iii) to give attention to Officer’s investments provided that such activities do not interfere
with the performance of his duties and responsibilities enumerated herein. 
  

	 	4.	TERMINATION OF EMPLOYMENT. 

 (a) Cause. For purposes of this Agreement,
“Cause” shall mean: 
 (i) an intentional act of fraud, embezzlement, theft or any other material violation of law that occurs
during or in the course of the Officer’s employment with the Company; 
 (ii) intentional damage by Officer to the Company’s
assets; 
 (iii) intentional disclosure by Officer of the Company’s confidential information contrary to the Company policies; 

(iv) material breach of the Officer’s obligations under this Agreement; 

(v) intentional engagement by the Officer in any activity which would constitute a breach of the Officer’s duty of loyalty or of the
Officer’s assigned duties; 
 (vi) intentional breach by the Officer of any of the Company’s policies and procedures; 

 (vii) the willful and continued failure by Officer to perform the Officer’s assigned duties
(other than as a result of incapacity due to physical or mental illness); or 
 (viii) willful conduct by the Officer that is demonstrably
and materially injurious to the Company, monetarily or otherwise. 
 (b) Good Reason. For purposes of this Agreement, “Good
Reason” shall mean the assignment to the Officer, without the Officer’s consent, of any duties materially inconsistent with the Officer’s position (including changes in status, offices, or titles and any change in the Officer’s
reporting requirements that would cause Officer to report to an officer who is junior in seniority to the officer to whom Officer reports), authority, duties or responsibilities, determined as of the later of the date of this Agreement or the date
of any modification to Officer’s position (including status, offices, titles and reporting requirements, as described above), authority, duties or responsibilities that is agreed to by Officer, or any other action by the Company that results in
a material diminution in such position, authority, duties, responsibilities or Officer’s aggregate compensation, excluding for this purpose an isolated, insubstantial and inadvertent action taken in good faith and which is remedied by the
Company within thirty (30) days after receipt of notice thereof given by the Officer (each of these an “Event” for purposes of this Section 4(b)). Officer must notify the Company of any Event that constitutes Good Reason within
ninety (90) days following Officer’s knowledge of the existence of such Event or such Event shall not constitute Good Reason under this Agreement. 

(c) Notice of Termination. Any Termination by the Company for Cause, or by the Officer for Good Reason, shall be communicated by Notice
of Termination to the other party hereto given in accordance with Section 11(b) of this Agreement. For purposes of this Agreement, a “Notice of Termination” means a written notice which (i) indicates the specific termination
provision in this Agreement relied upon, (ii) to the extent applicable, sets forth in reasonable detail the facts and circumstances claimed to provide a basis for termination of the Officer’s employment under the provision so indicated and
(iii) specifies the termination date (which date shall not be more than thirty (30) days after the giving of such notice; provided, however, if Officer is terminating for Good Reason such date shall not be less than thirty
(30) nor more than forty-five (45) days after giving of such notice). The failure by the Officer or the Company to set forth in the Notice of Termination any fact or circumstance which contributes to a showing of Good Reason or Cause shall
not waive any right of the Officer or the Company, respectively, hereunder or preclude the Officer or the Company, respectively, from asserting such fact or circumstance in enforcing the Officer’s or the Company’s rights hereunder. 

(d) Date of Termination. “Date of Termination” means the date of receipt of the Notice of Termination, or any later date
specified therein, as the case may be. The Company and the Officer shall take all steps necessary (including with regard to any post-Termination services by the Officer) to ensure that any Termination described in this Section 4 constitutes a
“separation from service” within the meaning of Section 409A of the Code, and notwithstanding anything contained herein to the contrary, the date on which the separation from service takes place shall be the “Date of
Termination.” 

 (e) Covenants Necessary to the Company’s Business. 

(i) Non-Solicitation of Customers. The Officer covenants and agrees that, during the term of this Agreement and for a period of one
(1) year following the termination of this Agreement, Officer will not, either directly or indirectly, in competition with the Company Business (as defined below), solicit, entice or recruit for a Competing Business (as defined below), attempt
to solicit, entice or recruit for a Competing Business, or attempt to divert or appropriate to a Competing Business, any actual or prospective customer of the Company with whom Officer had contact on behalf of the Company. For the purposes of this
Agreement, “Company Business” shall mean the business of (A) processing cardiac or vascular tissues, (B) marketing biological glue or protein hydrogel technology products, (C) marketing transport or other solutions for use
with human organs to be transplanted and/or (D) marketing hemostatic agents for use in surgeries. “Competing Business” shall mean any person or entity that engages in a commercial business that is the same as or substantially similar
to the Company Business, and only that portion of the business that is in competition with the Company Business. 
 (ii)
Non-Solicitation of Employees. Officer covenants and agrees that, during the term of this Agreement for a period of one (1) year following the Date of Termination, Officer will not, either directly or indirectly, solicit, entice,
encourage, cause, or recruit any person employed by the Company and with whom Officer had contact during Officer’s employment with the Company to leave such person’s employment with the Company to join a Competing Business. 

(iii) Consideration for Covenants. Officer covenants and agrees that the payment of any Severance Payment (as defined in
Section 5(e)) shall be subject to and expressly conditioned upon Officer’s compliance with the covenants set forth in subparagraphs (i) and (ii) above. Should Officer fail to comply with these covenants, the Company shall not be
required to make the Severance Payment (or any portion of the Severance Payment that remains unpaid), and the Officer shall be required to repay any portion of the Severance Payment that the Officer has already received from the Company. 

 

	 	5.	OBLIGATIONS OF THE COMPANY UPON TERMINATION. 

 (a) If, during the two (2) year
period commencing on the Effective Date and ending on the second anniversary of the Effective Date, (i) the Company shall Terminate the Officer’s employment without Cause, or (ii) the Officer shall Terminate employment for Good
Reason, then the Company shall pay to Officer the Severance Payment (defined below). 
 (b) Severance Payment. The “Severance
Payment” shall be an amount equal to one (1) times the aggregate of Officer’s base salary as of the Date of Termination and bonus compensation for the year in which the Termination of employment occurs. For purposes of determining
Officer’s bonus compensation for purposes of this Section 5(b), if the Date of Termination occurs before the awarding of bonuses for the year in which the Date of Termination occurs, the bonus compensation component of the Severance
Payment shall be computed based on Officer’s most recent awarded bonus; provided, however, that if the Date of Termination occurs prior to the determination of the amount of Officer’s 2015 bonus, the bonus compensation component of the
Severance Payment shall equal Officer’s target bonus for 2015 of 40%, reduced by a prorated amount to reflect the number of months during 2015 that Officer would have been 

 
employed by the Company had her employment terminated on December 31, 2015. Bonus compensation shall include both the Annual Bonus paid in cash and the value of any non-cash bonuses, such as
options or restricted stock. Any such options will be valued pursuant to the Black Scholes valuation method as of the grant date, using the same assumptions used by the Company in computing the FAS 123R charge for the options, and any shares of
restricted stock will be valued at the closing price of the Company Common Stock on The New York Stock Exchange on the date of issuance. The Company’s annual option and restricted stock grants shall not be deemed to be bonus compensation unless
they are specifically designated as such by the Compensation Committee of the Company’s Board of Directors. For the sake of clarification, all cash paid and any shares issued in payment of all or a portion of the bonus pursuant to the
Company’s 2007 Executive Incentive Plan or any successor thereto shall be bonus compensation for purposes of this Agreement for the year in which paid or issued. The Severance Payment shall be payable to Officer as follows: 

(i) The Severance Payment, if any is due hereunder, shall be paid to Officer in a lump sum not later than thirty (30) days following
Officer’s Date of Termination. 
 (ii) In the event of an Anticipatory Termination, the Severance Payment shall be paid to Officer in
a lump sum not later than thirty (30) days following the date of the Change of Control. 
 Notwithstanding the foregoing, if any amount
paid pursuant to this Section 5(b) is deferred compensation within the meaning of Section 409A of the Code and as of the Date of Termination Officer is a Specified Employee, amounts that would otherwise be payable during the six-month
period immediately following the Date of Termination shall instead be paid, with interest on any delayed payment at the applicable federal rate provided for in Section 7872(f)(2)(A) of the Code, on the first business day after the date that is
six months following Officer’s “separation from service” within the meaning of Section 409A of the Code (the “Delayed Payment Date”). As used in this Agreement, the term “Specified Employee” means a
“specified employee” as defined in Section 409A(a)(2)(B)(i) of the Internal Revenue Code of 1986, as amended (the “Code”). By way of clarification, “specified employee” means a “key employee” (as defined
in Section 416(i) of the Code, disregarding Section 416(i)(5) of the Code) of the Company. Officer shall be treated as a key employee if the Officer meets the requirement of Section CNM,416(i)(1)(A)(i), (ii), or (iii) at any time
during the twelve (12) month period ending on an “identification date”. For purposes of any “Specified Employee” determination hereunder, the “identification date” shall mean the last day of each calendar year.

  

	 	6.	FULL SETTLEMENT. 

 In no event shall the Officer be obligated to seek other employment or
take any other action by way of mitigation of the amounts payable to the Officer under any of the provisions of this Agreement and such amounts shall not be reduced whether or not the Officer obtains other employment. The Company agrees to pay, to
the full extent permitted by law, all legal fees and expenses which the Officer may reasonably incur as a result of any contest by the Company or Officer with respect to liability under or the interpretation of the validity or enforceability of, any
provision of this Agreement, but only in the event and to the extent that (i) the Officer receives a final, non-appealable judgment in his favor in any such action or receives a final judgment in his favor that has not been appealed by the
Company within thirty (30) days of the date of the judgment; or (ii) the parties agree to dismiss any such action upon the Company’s payment of the sums allegedly due the Officer or performance of the covenants by the Company
allegedly breached by it. 

	 	7.	PAYMENT CUT-BACK. 

 (a) Notwithstanding anything to the contrary contained herein, the
Company will not pay to Officer any excise tax gross up pursuant to this Agreement or any other agreement between Officer and the Company. Further notwithstanding anything to the contrary contained herein, the Company shall reduce any payment
contingent on a Change of Control pursuant to any plan, agreement, or arrangement of the Company that would be considered in determining whether a “parachute payment” (as defined in Section 280G (“Section 280G”) of the
Code), has occurred (“Change of Control Severance Payment”) to 2.99 times Employee’s average compensation, as indicated on such Employee’s Form W-2, for the five (5) years ending immediately prior to the year containing the
date of the Change of Control (the “Safe Harbor Amount”) if, and only if, reducing the Change of Control Severance Payment would provide Officer with a greater net after-tax Change of Control Severance Payment than would be the case if no
such reduction took place. The Safe Harbor Amount, as defined herein, is an amount expressed in present value which maximizes the aggregate present value of the Change of Control Severance Payment without causing the Change of Control Severance
Payment to be subject to the excise tax under Section 4999 (and related Section 280G) of the Code (the “Excise Tax”), determined in accordance with Section 280G(d)(4). Any reduction in the Change of Control Severance Payment
shall be implemented in accordance with Section 7(b). 
 (b) (i) Any reduction in payments pursuant to Section 7(a) shall
apply to cash payments and/or vesting of equity awards so as to minimize the amount of compensation that is reduced (i.e., it applies to payments or vesting that to the greatest extent represent parachute payments), with the amount of compensation
based on vesting to be based on all facts and circumstances as of the date of such vesting; provided, however, the reduction shall first be applied to cash payments and only applied to equity awards thereafter, such that equity awards are only
reduced to the extent absolutely necessary; further, provided, however, no reduction shall be applied to an amount that constitutes a deferral of compensation under Section 409A except for amounts that have become payable at the
time of the reduction and as to which the reduction will not result in a non-reduction in a corresponding amount that is a deferral of compensation under Section 409A that is not currently payable. 

(i) For purposes of determining whether the Change of Control Severance Payment will be subject to the Excise Tax and the amount of such
Excise Tax: 
 (A) The Change of Control Severance Payment shall be treated as a “parachute payment” within the meaning of
Section 280G(b)(2), and if it is an “excess parachute payment” within the meaning of Section 280G(b)(1), it shall be treated as subject to the Excise Tax, unless, and except to the extent that, in the written opinion of
independent compensation consultants, counsel or auditors of nationally recognized standing (“Independent Advisors”) selected by the Company and reasonably acceptable to Officer, the Change of Control Severance Payment (in whole or in
part) does not constitute a parachute payment, or such excess parachute payment (in whole or in part) represents reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) in excess of the base amount within
the meaning of Section 280G(b)(3) or are otherwise not subject to the Excise Tax. 

 (B) The value of any non-cash benefits or any deferred payment or benefit shall be determined by
the Independent Advisors in accordance with the principles of Sections 280G(d)(3) and (4). 
 (ii) For purposes of determining
reductions in compensation pursuant to this Section 7(b), if any, Officer will be deemed (A) to pay federal income taxes at the applicable rates of federal income taxation for the calendar year in which the compensation would be payable;
and (B) to pay any applicable state and local income taxes at the applicable rates of taxation for the calendar year in which the compensation would be payable, taking into account any effect on federal income taxes from payment of state and
local income taxes. Compensation will be adjusted not later than the applicable deadline under Section 409A to provide for accurate payments under the cut-back provision of this Section 7(b), but after any such deadline no further
adjustment will be made if it would result in a tax penalty under Section 409A. 
 (c) Furthermore, notwithstanding anything in this
Agreement to the contrary, aggregate severance, separation and/or similar payments made to Officer pursuant to this Agreement and otherwise shall be limited to the equivalent of Officer’s salary paid during the three (3) completed fiscal
years ended prior to the Date of Termination, including bonuses and guaranteed benefits paid during those years. 
  

	 	8.	CONFIDENTIAL INFORMATION. 

 The Officer and the Company will also be parties to one or
more separate agreements respecting confidential information, trade secrets, inventions and non-competition (collectively, the “IP Agreements”). The parties agree that the IP Agreements shall not be superseded or terminated by this
Agreement and shall survive any termination of this Agreement; provided, however, that to the extent that there is any conflict or overlap between the provisions of this Agreement and any of the IP Agreements, those provisions that provide the
Company with the greatest rights and protections shall control. 
  

	 	9.	SUCCESSORS. 

 (a) This Agreement is personal to the Officer and without the prior written
consent of the Company shall not be assignable by the Officer otherwise than by will or the laws of descent and distribution. This Agreement shall inure to the benefit of and be enforceable by the Officer’s legal representatives. 

(b) This Agreement shall inure to the benefit of and be binding upon the Company and its successors and assigns. 

(c) The Company will require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or
substantially all of the business and/or assets of the Company to assume expressly and agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform it if no such succession had taken place.
As used in this Agreement, “the Company” shall mean CryoLife as hereinbefore defined and any successor to its business and/or assets as aforesaid which assumes and agrees to perform this Agreement by operation of law, or otherwise. 

	 	10.	COMPLIANCE WITH SECTION 409A. 

 (a) This Agreement is intended to comply with, or
otherwise be exempt from, Section 409A of the Code and any regulations and Treasury guidance promulgated thereunder. 
 (b) The Company
and Officer agree that they will execute any and all amendments to this Agreement as they mutually agree in good faith may be necessary to ensure compliance with Section 409A of the Code. 

(c) The Company makes no representation or warranty as to the tax effect of any of the preceding provisions, and the provisions of this
Agreement shall not be construed as a guarantee by the Company of any particular tax effect to Officer under this Agreement. The Company shall not be liable to Officer or any other person for any payment made under this Agreement which is determined
to result in the imposition of an excise tax, penalty or interest under Section 409A of the Code, nor for reporting in good faith any payment made under this Agreement as an amount includible in gross income under Section 409A of the Code.

  

	 	11.	MISCELLANEOUS. 

 (a) This Agreement shall be governed by and construed in accordance with
the laws of the State of Georgia, without reference to principles of conflict of laws. The captions of this Agreement are not part of the provisions hereof and shall have no force and effect. This Agreement may not be amended or modified otherwise
than by a written agreement executed by the parties hereto or their respective successors and legal representatives. 
 (b) All notices and
other communications hereunder shall be in writing and shall be given by hand delivery (which shall include delivery via Federal Express or UPS) to the other party or by registered or certified mail, return receipt requested, postage prepaid,
addressed as follows: 
 If to the Officer: 

Jean F. Holloway 
 2025 Barrett
Lakes Blvd #2107 
 Kennesaw, GA 30144 

If to the Company: 
 CryoLife,
Inc. 
 1655 Roberts Boulevard, N.W, 

Kennesaw, Georgia 30144 

Attention: Chief Executive Officer 
 or to such
other address as either party shall have furnished to the other in writing in accordance herewith. Notice and communications shall be effective when actually received by the addressee. 

 (c) If any provision of this Agreement or the application of any provision hereof to any person
or circumstance is held invalid, unenforceable or otherwise illegal, the remainder of this Agreement and the application of such provision to any other person or circumstance shall not be affected, and the provision so held to be invalid,
unenforceable or otherwise illegal shall be reformed to the extent (and only to the extent) necessary to make it valid, enforceable and legal; provided, however, if the provision so held to be invalid, unenforceable or otherwise illegal cannot be
reformed so as to be valid and enforceable, then it shall be severed from, and shall not affect the enforceability of, the remaining provisions of the Agreement. 

(d) The Company may withhold from any amounts payable under this Agreement such federal, state, local or foreign taxes as shall be required to
be withheld pursuant to any applicable law or regulation. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date first 
  

			
	 /s/ Jean F. Holloway

	Jean F. Holloway
	
	CRYOLIFE, INC.
		
	By:	 	 /s/ James P. Mackin

		 	James P. Mackin
		 	President and CEO

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