Document:

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                                                                   Exhibit 10.72

           THE SECURITIES REPRESENTED HEREBY HAVE BEEN ISSUED WITHOUT
           REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR
           UNDER ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD,
           TRANSFERRED OR PLEDGED IN THE ABSENCE OF AN EFFECTIVE
           REGISTRATION STATEMENT UNDER APPLICABLE FEDERAL AND STATE
           SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY
           TO THE COMPANY THAT THE TRANSFER IS EXEMPT FROM REGISTRATION
           UNDER APPLICABLE FEDERAL AND STATE SECURITIES LAWS.

                         VYTERIS HOLDINGS (NEVADA), INC.
                         10% CONVERTIBLE PROMISSORY NOTE

$250,000                                                   Fair Lawn, New Jersey
                                                                January 31, 2006

        FOR VALUE RECEIVED, the undersigned, Vyteris Holdings (Nevada), Inc., a
Nevada corporation (the "Issuer"), hereby unconditionally promises to pay, in
accordance with the Note and Warrant Purchase Agreement (the "Note and Warrant
Purchase Agreement"), dated as of the date hereof, by and between the Issuer and
Spencer Trask Specialty Group, LLC, a Delaware limited liability company (the
"Purchaser"), on the Maturity Date (as defined in the Note and Warrant Purchase
Agreement) to the order of the Purchaser, at the office of the Purchaser located
at 535 Madison Avenue, New York, NY or such other address designated by the
Purchaser, in lawful money of the United States of America and in immediately
available funds, the principal amount of Two Hundred Fifty Thousand ($250,000)
Dollars. The Issuer further agrees to pay interest on the unpaid principal
amount outstanding hereunder from time to time from the date hereof in like
money at the rates and as and on the dates specified in Section 3.3 of the Note
and Warrant Purchase Agreement.

        This Note is the promissory note referred to in the Note and Warrant
Purchase Agreement, and is entitled to the benefits thereof, and is subject to
conversion as set forth therein. This Note, and all representations, warranties,
covenants and agreements contained herein and in the Note and Warrant Purchase
Agreement, shall be binding upon Issuer and its successors and permitted assigns
and shall inure to the benefit of the Purchaser and its successors and assigns.
Issuer may not assign or delegate any of its duties or obligations under this
Note without the written consent of the Purchaser, which shall not be
unreasonably withheld.

        Upon the occurrence of any one or more of the Events of Default
specified in the Note and Warrant Purchase Agreement, all amounts then remaining
unpaid on this Note shall become, or may be declared to be, immediately due and
payable, all as provided in the Note and Warrant Purchase Agreement.

        All parties now and hereafter liable with respect to this Note, whether
maker, principal, surety, guarantor, endorser or otherwise, hereby waive
presentment, demand, protest

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and all other notices of any kind.

        Subject to Sections 3.3 and 10.5 of the Note and Warrant Purchase
Agreement, the Issuer agrees to pay all of the Purchaser's expenses, including
reasonable attorneys' costs and fees, incurred in collecting sums due under this
Note.

        This Note shall be governed by, and construed and interpreted in
accordance with, the laws of the State of New York.

                                           VYTERIS HOLDINGS (NEVADA), INC.

                                           By: /s/ Timothy J. McIntyre
                                               Name: Timothy J. McIntyre
                                               Title: President & Chief
                                                      Executive Officer

                                           By: /s/ Michael McGuinness
                                               Name: Michael McGuinness
                                               Title: Chief Financial Officer

                                      -2-<PAGE>

                                                                   Exhibit 10.73

                       NOTE AND WARRANT PURCHASE AGREEMENT

        NOTE AND WARRANT PURCHASE AGREEMENT (this "Agreement"), dated as of
January 31, 2006, by and between Vyteris Holdings (Nevada), Inc., a Nevada
corporation ("Seller"), and Spencer Trask Specialty Group, LLC, a Delaware
limited liability company ("Buyer").

                              W I T N E S S E T H:
                              - - - - - - - - - -

        WHEREAS, Seller desires to issue to Buyer, and Buyer desires to purchase
from Seller, a convertible subordinated promissory note, substantially in the
form of EXHIBIT A hereto, in the principal amount of $250,000 (the "Note");

        WHEREAS, in connection herewith, Seller has agreed to issue to Buyer a
warrant (the "Warrant") to purchase 52,083 shares of Seller's common stock, par
value $.001 ("Common Stock") as set forth in the warrant agreement substantially
in the form of EXHIBIT B hereto (the "Warrant Agreement");

        WHEREAS, Seller has agreed to effect the registration of the shares of
Common Stock underlying the Note and the Warrants under the Securities Act of
1933, as amended, pursuant to a registration statement substantially in the form
of Exhibit C hereto (the "Registration Rights Agreement"); and

        WHEREAS, Seller, pursuant to that certain securities purchase agreement
dated as of August 19, 2005, as same may be amended from time to time
("Securities Purchase Agreement") issued a series of senior secured convertible
debentures, including debentures issued after the original issuance date (the
"Debentures") in the aggregate principal amount of $10.5 million (the "Senior
Debt").

        NOW, THEREFORE, in consideration of the mutual covenants and agreements
hereinafter set forth herein and for good and valuable consideration, the
receipt and sufficiency of which are hereby mutually acknowledged, the parties
agree as follows:

        1.      SALE AND PURCHASE OF THE NOTE AND WARRANT

        1.1.    SALE AND PURCHASE. Subject to the terms and conditions of this
Agreement, at the Closing (as defined in Section 2.1 hereof), Seller shall issue
to Buyer, and Buyer shall purchase from Seller, for the Purchase Price (as
defined in Section 1.2(a) hereof), the Note and the Warrant.

        1.2.    PURCHASE PRICE AND PAYMENT.

                (a)     PURCHASE PRICE. The purchase price for the Note and the
Warrant shall be $250,000 (the "Purchase Price").

                (b)     PAYMENT OF PURCHASE PRICE. The Purchase Price shall be
paid to Seller by Buyer on the Closing Date (as defined in Section 2.1 hereof)
via federal funds wire

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transfer(s) of immediately available funds, in accordance with written
instructions provided to Buyer prior to the date hereof.

        2.      CLOSING.

        2.1.    TIME AND PLACE. The closing of the sale and purchase of the Note
and Warrant (the "Closing") shall be deemed to take place at the offices of
Littman Krooks LLP, 655 Third Avenue, 20th Floor, New York, New York, at 10:00
a.m., local time, on the date hereof, or at such later time or date as Buyer and
Seller may mutually agree in writing. The date upon which the Closing shall
occur is herein called the "Closing Date".

        2.2.    CLOSING DELIVERIES.

                (a)     SELLER DELIVERIES. At the Closing, Seller shall deliver
or cause to be delivered to Buyer the following:

                        (i)     the duly executed Note;

                        (ii)    the duly executed Warrant Agreement;

                        (iii)   the duly executed Registration Rights Agreement;
and

                        (iv)    copies of any consents necessary to effectuate
this Agreement and to consummate the transactions contemplated hereby.

                (b)     BUYER DELIVERY. At the Closing, Buyer shall deliver or
cause to be delivered to Seller the Purchase Price.

        3.      TERMS OF THE NOTE.

        3.1.    AMOUNT. The principal amount of the Note shall be $250,000.

        3.2.    MATURITY. Unless otherwise converted into the Conversion Shares
(as defined in Section 3.4 hereof) in accordance with the provisions hereof, the
Note shall mature on December 1, 2008, unless such date shall be otherwise
extended in writing by Buyer, in its sole discretion (such date, the "Maturity
Date"). On the Maturity Date, unless, and to the extent, converted into
Conversion Shares in accordance with the provisions hereof, all outstanding
principal and any accrued and unpaid interest due and owing under the Note shall
be immediately paid by Seller.

        3.3.    INTEREST; INTEREST RATE; PAYMENT. (a) The Note shall bear
interest (other than interest accruing as a result of a failure by Seller to pay
any amount when due as set forth in clause (b) below) at a rate equal to ten
(10%) percent (the "Interest Rate") per annum on a 360-day year. Interest (other
than interest accruing as a result of a failure by Seller to pay any amount when
due as set forth in subparagraph (b) below) shall be due and payable in cash
semi-annually in arrears following the end of each semi-annual period,
commencing with the semi-annual period ended June 30, 2006, pro rated for
partial periods; PROVIDED, HOWEVER, that any

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interest accruing on overdue amounts pursuant to subparagraph (b) of this
Section 3.3 shall be payable on demand.

                (b)     If all or a portion of the principal amount of the Note
or any interest payable thereon shall not be repaid when due whether on the
applicable repayment date, by acceleration or otherwise, such overdue amounts
shall bear interest at a rate per annum that is three percent (3%) above the
Interest Rate (I.E., 13%) from the date of such non-payment until such amount is
paid in full (as well after as before judgment).

                (c)     All payments to be made by Seller hereunder or pursuant
to the Note shall be made, without setoff or counterclaim, in lawful money of
the United States by check or wire transfer in immediately available funds.

        3.4.    CONVERSION. Subject to Section 3.5 hereof, at any time prior to
the Maturity Date, the Seller shall have the option to convert the entire
principal and interest accrued and owing on the Note, or any portion of the
principal and/or interest thereof, into shares (the "Conversion Shares") of
Common Stock at the Conversion Price. For purposes hereof, "Conversion Price"
shall mean $2.40 per share; PROVIDED, that if at any time on or after the
issuance date of the Note, Seller subdivides (by any stock split, stock
dividend, recapitalization, reorganization, reclassification or otherwise) its
shares of Common Stock into a greater number of shares, then after the date of
record for effecting such subdivision, the Conversion Price shall be
proportionately reduced, or if Seller combines (by reverse stock split,
recapitalization, reorganization, reclassification or otherwise) its shares of
Common Stock into a smaller number of shares, the Conversion Price shall be
proportionately increased.

Upon conversion, Buyer shall be entitled to receive the number of Conversion
Shares calculated by dividing the amount being converted by the Conversion
Price. No fractional shares of Conversion Shares shall be issued upon
conversion. In lieu of any fractional shares to which Buyer would otherwise be
entitled, Seller shall pay cash in an amount equal to such fraction multiplied
by the Conversion Price. The Note shall not be subject to automatic conversion
or to any conversion at the option of Seller.

        3.5.    CONVERSION PROCEDURES. In order to exercise the conversion
rights set forth in Section 3.4 hereof, Buyer shall surrender the Note,
appropriately endorsed, to Seller at Seller's principal office, accompanied by
written notice to Seller setting forth the amount of principal and interest to
be converted, the name or names (with address(es)) in which the Conversion
Shares issuable upon such conversion shall be issued and registered on the books
of Seller. For purposes hereof, the "Conversion Date" shall be deemed to be the
date the Note and notice is received by Seller for conversion. Within five (5)
business days after the Conversion Date, Seller shall deliver to Buyer (i) a
stock certificate for the Conversion Shares or (ii) a notice certified by
Seller's Secretary that the Conversion Shares due on such conversion have been
issued to and registered on the books of Seller in the name or names specified
by Buyer. In the case of conversion of less than the entire principal of and
interest under the Note, Seller shall cancel said Note and shall execute and
deliver a new Note of like tenor for the unconverted amount of the Note dated
the date of execution by Seller upon initial issuance of the Note
notwithstanding any subsequent substitution.

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        3.6.    SUBORDINATION. The Note is expressly and fully subordinated, as
to payment and liquidation, to the payment in full of the Debentures and the
Obligations (as such term is defined in the Securities Purchase Agreement) and
the holder of the Note acknowledges and agrees that the Seller is expressly
restricted from pre-paying any amounts in respect of the principal of the Note
(upon acceleration or otherwise) until payment in full of the Debentures. The
holder of this Note shall not commence any judicial or other collection efforts
or exercise any other remedies prior to the date that is ninety-one (91) days
following the payment in full of the Debentures. The Note is, and is intended to
be, "Subordinated Debt" as such term is defined in the Securities Purchase
Agreement.

        3.7.    PREPAYMENT RIGHTS UPON MERGER, CONSOLIDATION, ETC. (a) If, prior
to the Conversion Date, but subject to the provisions of Section 3.6 above,
Seller proposes to consolidate with, or merge into, another corporation or
entity, or to effect any sale or conveyance to another corporation or entity of
all or substantially all of the assets of Seller, or effect any other corporate
reorganization, in which the stockholders of the Seller immediately prior to
such consolidation, merger or reorganization own capital stock of the entity
surviving such merger, consolidation or reorganization representing less than
fifty (50%) percent of the combined voting power of the outstanding securities
of such entity immediately after such consolidation, merger or reorganization
(collectively, a "Liquidation Event"), then Seller shall provide Buyer with at
least ten (10) days' prior written notice of any such proposed action, and Buyer
will, at its option, have the right to demand immediate prepayment of all
amounts due and owing under the Note. Buyer will give Seller written notice of
such demand within five (5) days after receiving notice of the Liquidation
Event. All amounts (including all accrued and unpaid interest) due and owing
under the Note shall be paid by Seller to Buyer within five (5) days from the
date of such written notice via federal funds wire transfer(s) of immediately
available funds, in accordance with written instructions to be provided to
Seller by Buyer within at least two (2) business days after giving Seller such
written notice. The provisions of this Section 3.7(a) shall similarly apply to
successive consolidations or mergers.

        (b)     Except as set forth in Sections 3.6, 3.7(a) and 9 hereof, Seller
shall not prepay prior to the Maturity Date all or part of this Note without the
express written consent of Buyer.

        3.8     INTENTIONALLY DELETED

        3.9     ASSURANCES WITH RESPECT OF CONVERSION RIGHTS. Seller shall not,
by amendment of its Certificate of Incorporation or By-laws or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other voluntary action, avoid or seek to avoid the
observance or performance of any of the terms to be observed or performed
hereunder by Seller but shall at all times in good faith assist in the carrying
out of all the provisions of this Agreement and in taking of all such actions as
may be necessary or appropriate in order to protect the conversion rights of
Buyer against impairment.

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        4.      REPRESENTATIONS AND WARRANTIES OF SELLER. Seller hereby
represents and warrants to Buyer as follows:

        4.1     DUE ORGANIZATION AND QUALIFICATION. Seller is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Nevada. Seller has all requisite power and authority to own, lease and operate
its assets and properties and to carry on its business as presently conducted
and as presently contemplated. Seller is duly qualified to transact business and
is in good standing in each jurisdiction in which the nature of its business or
the locations of its property requires such qualification, except where the
failure to do so would not have a material adverse effect on Seller's business,
operations, assets or condition (financial or otherwise).

        4.2     POWER AND AUTHORITY. Seller has the requisite corporate power
and authority to execute and deliver this Agreement and all other agreements
contemplated by this Agreement (including, without limitation, the Note, the
Registration Rights Agreement and Warrant Agreement) and to perform its
obligations hereunder and thereunder. The execution, delivery and performance of
this Agreement and all other agreements contemplated by this Agreement have been
duly authorized by all necessary corporate action on the part of Seller. This
Agreement has been duly executed and delivered by Seller and is the valid and
binding obligation of Seller, enforceable against Seller in accordance with its
terms, except as such enforceability may be limited by applicable bankruptcy,
moratorium, insolvency, reorganization or other similar laws now or hereafter in
effect generally affecting the enforcement of creditors' rights, specific
performance, injunctive or other equitable remedies. When executed and delivered
by Seller at the Closing, each of the Note, the Registration Rights Agreement
and the Warrant Agreement will be the valid and binding obligation of Seller,
enforceable against Seller in accordance with its terms, except as such
enforceability may be limited by bankruptcy, moratorium, insolvency,
reorganization or other similar laws now or hereafter in effect generally
affecting the enforcement of creditors' rights, specific performance, injunctive
or other equitable remedies.

        4.3.    CAPITALIZATION. The capitalization of the Seller as of the date
of this Agreement, including its authorized capital stock, the number of shares
issued and outstanding, the number of shares issuable and reserved for issuance
pursuant to the Seller's stock option plans and agreements, the number of shares
issuable and reserved for issuance pursuant to securities (other than the Note
and Warrants) exercisable for, or convertible into or exchangeable for any
shares of Common Stock and the number of shares initially to be reserved for
issuance upon conversion of the Note and exercise of the Warrants, is set forth
on Schedule 4.3 hereto. All issued and outstanding shares of capital stock of
the Seller have been validly issued, fully paid and non-assessable. Except as
disclosed on Schedule 4.3 hereto, the Seller owns all of the capital stock of
each subsidiary, which capital stock is validly issued, fully paid and
non-assessable, and no shares of the capital stock of the Seller or any of the
subsidiaries are subject to preemptive rights or any other similar rights of the
shareholders of the Seller or any such subsidiary or any liens created by or
through the Seller or any such subsidiary. Except as disclosed on Schedule 4.3
or as contemplated herein, there are no outstanding options, warrants, scrip,
rights to subscribe to, calls or commitments of any character whatsoever
relating to, or securities or rights convertible into or exercisable or
exchangeable for, any shares of capital stock of the Seller or any of the
subsidiaries, or arrangements by which the Seller or any of the subsidiaries is
or may become bound to issue

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additional shares of capital stock of the Seller or any of the subsidiaries
(whether pursuant to anti-dilution, "reset" or other similar provisions).
Schedule 4.3 identifies all Debt of the Seller and the subsidiaries currently
outstanding in excess of $100,000 individually or in the aggregate as of the
date hereof.

        4.4.    FINANCIAL STATEMENTS; OTHER INFORMATION. Seller has filed with
the Securities and Exchange Commission ("Commission") all reports, schedules,
registration statements and definitive proxy statements that Seller was required
to file with Commission on or after December 31, 2004 (collectively, the "SEC
DOCUMENTS"). Seller is not aware of any event occurring or expected to occur as
of the date of this Agreement (other than the transactions effected hereby) that
would require the filing of, or with respect to which Seller intends to file, a
Form 8-K after the date of this Agreement. Each SEC Document, as of the date of
the filing thereof with the Commission (or if amended or superseded by a filing
prior to the date of this Agreement, then on the date of such amending or
superseding filing), complied in all material respects with the requirements of
the Securities Act of 1933, as amended ("Securities Act") or Securities Exchange
Act of 1934, as amended ("Exchange Act"), as applicable, and the rules and
regulations promulgated thereunder and, as of the date of such filing (or if
amended or superseded by a filing prior to the date of this Agreement, then on
the date of such filing), such SEC Document (including all exhibits and
schedules thereto and documents incorporated by reference therein) did not
contain an untrue statement of material fact or omit to state a material fact
required to be stated therein or necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading. All
documents that are required to be filed as exhibits to the SEC Documents have
been filed as required. Except as set forth in Schedule 4.4, Seller has no
liabilities, contingent or otherwise, other than liabilities incurred in the
ordinary course of business that, under GAAP, are not required to be reflected
in the financial statements included in Schedule 4.4. Except as set forth in
Schedule 4.4, as of their respective dates, the financial statements of Seller
included in the SEC Documents complied as to form in all material respects with
applicable accounting requirements and the published rules and regulations of
the Commission with respect thereto. The financial statements included in the
SEC Documents have been and will be prepared in accordance with GAAP
consistently applied at the times and during the periods involved (except (i) as
may be otherwise indicated in such financial statements or the notes thereto,
(ii) in the case of unaudited interim statements, to the extent they may exclude
footnotes or may be condensed or summary statements, or (iii) as set forth in
the SEC Documents), and fairly present in all material respects the financial
position of Seller as of the dates thereof and the results of its operations and
cash flows for the periods then ended (subject, in the case of unaudited
statements, to normal year-end adjustments).

        4.5.    AUTHORIZATION OF THE NOTE, WARRANT AND CONVERSION SHARES. All
corporate action on the part of Seller necessary for the authorization,
issuance, sale and/or delivery of the Note, the Warrant and the capital stock
issuable upon exercise of the Warrant and conversion of the Note (the
"Conversion Shares") has been taken and when issued, sold and delivered in
accordance with this Agreement, the Note and/or the Warrant, the Conversion
Shares will be validly issued and outstanding, fully paid and nonassessable and
not subject to preemptive, first refusal or any other similar rights of any
stockholder of Seller or others.

        4.6     COMPLIANCE WITH LAWS. To its knowledge, Seller is in compliance
in all material respects with all Federal, state, local and foreign laws,
statutes, ordinances, regulations,

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orders, judgments, injunctions, awards or decrees (collectively, "Laws")
applicable to it or any of its properties or operations. Seller has not received
any notice of material violation or alleged material violation of any Law by it.
Seller has all material licenses, permits, orders and approvals of Federal,
state, local and foreign governmental or regulatory bodies necessary for the
conduct of its business and operations as presently conducted.

        4.7     NO BREACH; CONSENTS. Except as set forth on SCHEDULE 4.7 hereto,
the execution, delivery and performance of this Agreement by Seller and the
consummation by Seller of the transactions contemplated hereby will not (i)
result in any lien, pledge, mortgage, security interest, claim, lease, charge,
option, easement, servitude or other encumbrance whatsoever (collectively,
"Liens") upon any of the property of Seller (other than in favor of Buyer) or
(ii) violate, conflict with or breach any of the terms and conditions of, result
in a material modification of, accelerate or trigger the rights of any person
under, or constitute (or with notice or lapse of time or both would constitute)
a default under (a) any material instrument, contract or other agreement to
which Seller is a party or by or to which it or any of its properties is bound
or subject; (b) Seller's Certificate of Incorporation or By-laws (and all
amendments thereto up through the date hereof); or (c) any Law applicable to
Seller or any of its properties or operations. Except as set forth on SCHEDULE
4.7, no consent, approval or authorization of, or declaration or filing with,
any governmental authority, stockholder of Seller or other person is required on
the part of Seller in connection with the execution, delivery or performance of
this Agreement or the consummation by it of the transactions contemplated
hereby.

        4.8     LITIGATION. Except as set forth on SCHEDULE 4.8 hereto, there
are no material suits or actions, administrative, arbitration or other
proceedings or governmental investigations pending or, to Seller's knowledge,
threatened against or affecting Seller or any of its properties or assets. There
are no judgments, orders, injunctions, decrees or awards against Seller that are
not satisfied or remain outstanding.

        4.9.    BROKERS. Neither Seller nor any of Seller's officers, directors,
employees or stockholders has employed any broker or finder in connection with
the transactions contemplated by this Agreement and no fee is or will be due and
owing to any broker or finder in connection with the transactions contemplated
by this Agreement.

        4.10    INTELLECTUAL PROPERTY. All of Seller's (i) trademarks, trade
names, registered trademarks, trademark applications, service marks, registered
service marks and service mark applications, (ii) patents and patent
applications, and (iii) licenses with respect to the use of patents or
trademarks owned by other parties, are set forth on SCHEDULE 4.10 hereto. Except
as set forth on SCHEDULE 4.10, there is not pending nor, to Seller's knowledge,
threatened any claim, suit or action contesting or challenging the rights of
Seller in or to any of the material item of intellectual property owned or used
by Seller in the conduct of its business (the "Intellectual Property") or the
validity of any of the Intellectual Property. To Seller's knowledge, there is no
infringement upon or unauthorized use of any of the Intellectual Property by any
third party. No officer, director, equityholder or affiliate of Seller nor any
of their respective associates has any right to or interest in any of the
Intellectual Property, including, without limitation, any right to payments (by
royalty or otherwise) in respect of any use or transfer thereof.

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        4.11    PERFORMANCE OF AGREEMENTS. Except as set forth on SCHEDULE 4.11
hereto, no default by Seller exists in the due performance under any material
agreement to which Seller is a party or to which any of its assets is subject.

        4.12    NO WAIVER OF PRIOR OR FUTURE DEFAULTS. Seller hereby
acknowledges and agrees that this Agreement and Buyer's purchase from Seller of
the Note, pursuant to the terms and conditions hereof, shall not constitute or
operate as a waiver or release of any default, or any future defaults, under the
Default Notes.

        5.      REPRESENTATIONS AND WARRANTIES OF BUYER. Buyer hereby represents
and warrants to Seller as follows:

        5.1     DUE ORGANIZATION. Buyer is a duly organized legal entity,
validly existing and in good standing under the laws of the state of its
organization.

        5.2     POWER OF BUYER. Buyer has the requisite company power and
authority to execute and deliver this Agreement and to perform its obligations
hereunder. This Agreement has been duly executed and delivered by Buyer and is
the valid and binding obligation of Buyer, enforceable against Buyer in
accordance with its terms, except as such enforceability may be limited by
bankruptcy, moratorium, insolvency, reorganization or other similar laws
generally affecting the enforcement of creditors' rights, specific performance,
injunctive or other equitable remedies.

        5.3     NO BREACH. The execution, delivery and performance of this
Agreement by Buyer and the consummation by Buyer of the transactions
contemplated hereby will not violate, conflict with or otherwise result in the
breach of any of the terms and conditions of, result in a material modification
of or constitute (or with notice or lapse of time or both would constitute) a
default under (i) any of the organizational documents of Buyer; (ii) any
material instrument, contract or other agreement to which Buyer is a party or by
or to which it or any of its properties is bound or subject; or (iii) any Law
applicable to Buyer or any of its properties or operations.

        5.4     GOVERNMENTAL AND OTHER CONSENTS. No consent, approval or
authorization of, or declaration or filing with, any governmental authority or
other person is required on the part of Buyer in connection with the execution,
delivery and performance of this Agreement by it or the consummation of the
transactions contemplated hereby.

        5.5     INVESTMENT REPRESENTATIONS. Buyer is acquiring the Note and the
Warrant (together, the "Securities"), and any capital stock issuable upon
exercise of the Securities, for Buyer's own account, for investment and not with
a view to, or for sale in connection with, any distribution of such securities
or any part thereof. Buyer (i) has such knowledge and experience in financial
and business affairs that it is capable of evaluating the merits and risks
involved in purchasing the Securities, (ii) is able to bear the economic risks
involving in purchasing the Securities, (iii) is an "accredited investor" as
defined in Rule 501(a) of Regulation D promulgated under the Securities Act and
(iv) has had the opportunity to ask questions of, and receive answers from,
Seller and persons acting on Seller's behalf concerning Seller's business,

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management, and financial affairs and the terms and conditions of the
Securities. Buyer's state of residence is New York.

        5.6.    NO BROKER. Buyer has not employed any broker or finder in
connection with the transactions contemplated by this Agreement.

        6.      COVENANTS AND AGREEMENTS.

        6.1     PRE-CLOSING COVENANTS AND AGREEMENTS. The parties hereto
covenant and agree to perform or take any and all such actions to effectuate the
following from the date hereof until the earlier of the Closing Date or the
termination of this Agreement:

        (a)     FURTHER ASSURANCES. Each of the parties shall, prior to or at
the Closing, as may be appropriate, execute such documents and other papers and
take such other further actions as may be reasonably required to carry out the
provisions hereof and effectuate the transactions contemplated hereby, and in
the Note, the Warrant Agreement and the Registration Rights Agreement. Each
party shall use its best efforts to fulfill or obtain the fulfillment of the
conditions to its obligation to effect the Closing, including promptly obtaining
any consents required in connection herewith.

        (b)     ADDITIONAL DISCLOSURE. Seller shall promptly notify Buyer of,
and furnish Buyer with, any information it may reasonably request with respect
to the occurrence of any event or condition or the existence of any fact that
would cause any of the conditions to Buyer's obligation to consummate the
transactions contemplated by this Agreement not to be fulfilled.

        6.2     POST-CLOSING COVENANTS AND AGREEMENTS. Buyer and Seller covenant
and agree from and after the Closing Date to perform or take the following
actions:

        (a)     RESERVE FOR CONVERSION SHARES. Seller shall at all times reserve
and keep available out of its authorized but unissued shares of Common Stock or
other securities for the purpose of issuing Common Stock or other securities
upon the conversion of the Note and/or the exercise in full of the Warrants. If
at any time the number of authorized but unissued shares of Common Stock or
other securities shall not be sufficient to satisfy the conversion of the Note
and the exercise of the Warrants, if any, Seller shall forthwith take such
corporate action as may be necessary to increase its authorized but unissued
shares of Common Stock or other securities to such number of shares as shall be
sufficient for such purpose. If any capital reorganization or any Liquidation
Event of Seller shall be effected in such a way that holders of Common Stock
shall be entitled to receive capital stock, securities or assets with respect to
or in exchange for Common Stock, then, as a condition of such reorganization,
reclassification or Liquidation Event, lawful and adequate provisions shall be
made whereby the holder of the Note and the Warrants shall thereafter, upon
conversion, have the right to receive such shares of capital stock, securities
or assets as may be issued or payable with respect to or in exchange for the
number of outstanding shares of such Common Stock into which the Note and/or
Warrants held at the time of such capital reorganization, reclassification or
Liquidation Event is convertible.

                                       9
<PAGE>

        7.      CONDITIONS PRECEDENT TO THE OBLIGATION OF BUYER TO CLOSE.

        7.1     CLOSING. The obligation of Buyer to complete the Closing is
subject to the fulfillment on or prior to the Closing Date of all of the
following conditions, any one or more of which may be waived by Buyer in
writing:

        (a)     AGREEMENTS AND CONDITIONS. On or before the Closing Date, Seller
shall have complied with and duly performed and satisfied in all material
respects all agreements and conditions on its part to be complied with and
performed by such date pursuant to this Agreement.

        (b)     CONSENTS. Seller shall have obtained any consents necessary to
effectuate this Agreement and to consummate the transactions contemplated hereby
and delivered copies thereof to Buyer.

        (c)     NOTE. Seller shall have duly executed and delivered to Buyer the
Note.

        (d)     WARRANT AGREEMENT. Seller shall have duly executed and delivered
to Buyer the Warrant Agreement.

        (e)     REGISTRATION RIGHTS AGREEMENT. Seller shall have duly executed
and delivered to Buyer the Registration Rights Agreement.

        8.      CONDITIONS PRECEDENT TO THE OBLIGATION OF SELLER TO CLOSE.

        8.1     CLOSING. The obligation of Seller to complete the Closing is
subject to the fulfillment on or prior to the Closing Date of all of the
following conditions, any one or more of which may be waived by Seller in
writing:

        (a)     AGREEMENTS AND CONDITIONS. On or before the Closing Date, Buyer
shall have complied with and performed and satisfied in all material respects
all agreements and conditions to be complied with and performed by such date
pursuant to this Agreement.

        (b)     WARRANT AGREEMENT. Buyer shall have duly executed and delivered
to Seller the Warrant Agreement.

        (c)     PAYMENT OF PURCHASE PRICE. Buyer shall have paid to Seller the
Purchase Price.

        (d)     REGISTRATION RIGHTS AGREEMENT. Buyer shall have duly executed
and delivered to Seller the Registration Rights Agreement.

        9.      EVENTS OF DEFAULT. If any of the following events (each, an
"Event of Default") shall occur and be continuing:

        (i)     Seller shall fail to pay any amount payable under the Note
within three (3) business days after such payment becomes due in accordance with
the terms thereof;

                                       10
<PAGE>

        (ii)    Seller shall fail to pay when due (following the expiration of
applicable notice and cure periods, if any), whether upon acceleration,
prepayment obligation or otherwise, any indebtedness and/or other sums payable,
individually or in the aggregate, involving an amount in excess of $100,000;

        (iii)   Any representation or warranty made or deemed made by Seller
herein or in any other agreement, certificate or instrument contemplated by this
Agreement or that is contained in any certificate, document or financial or
other statement furnished at any time under or in connection with this Agreement
shall have been incorrect in any material respect on or as of the date made or
deemed made;

        (iv)    Seller shall default, in any material respect, in the observance
or performance of any other agreement contained in this Agreement or any other
agreement or instrument contemplated by this Agreement, and such default shall
continue unremedied for a period of twenty (20) days after notice to Seller of
such default;

        (v)     Seller shall substantially curtail, alter, modify or change its
business operations, as reasonably determined by Buyer; or

        (vi)    (a) Seller shall commence any case, proceeding or other action
(x) under any existing or future law of any jurisdiction, domestic or foreign,
relating to bankruptcy, insolvency, reorganization, conservatorship or relief of
debtors, seeking to have an order for relief entered with respect to it, or
seeking to adjudicate it a bankrupt or insolvent, or seeking reorganization,
arrangement, adjustment, winding-up, liquidation, dissolution, composition or
other relief with respect to it or its debts, or (y) seeking appointment or a
receiver, trustee, custodian, conservator or other similar official for it or
for all or any substantial part of its assets, or Seller shall make a general
assignment for the benefit of its creditors; or (b) there shall be commenced
against Seller any case, proceeding or other action of a nature referred to in
clause (a) above that (A) results in the entry of an order for relief of any
such adjudication of appointment or (B) remains undismissed, undischarged or
unbonded for a period of sixty (60) days; or (c) there shall be commenced
against Seller any case, proceeding other action seeking issuance of a warrant
of attachment, execution, distrait or similar process against all or any
substantial part of its assets that results in the entry of an order for any
such relief which shall not have been vacated, discharged, or stayed or bonded
pending appeal within sixty (60) days from the entry thereof; or (d) Seller
shall take any action in furtherance of, or indicating its consent to, approval
of, or acquiescence in any of the acts set forth in clauses (a), (b) or (c)
above; or (e) Seller shall generally not, or shall be unable to, or shall admit
in writing its inability to, pay its debts as they become due,

        then, and in any such event, but in all events subject to the provisions
of Section 3.6 above, (x) if such event is an Event of Default specified in
subsection (vi) above of this Section 9 with respect to Seller, automatically
the Note (with all accrued and unpaid interest thereon) and all other amounts
owing under this Agreement and the Note shall immediately become due and
payable, and (y) if such event is any other Event of Default, Buyer may, by
written notice to Seller, declare the Note (with all accrued and unpaid interest
thereon) and all other amounts owing under this Agreement and the Note to be due
and payable forthwith, whereupon the same shall immediately become due and
payable. Except as expressly provided

                                       11
<PAGE>

above in this Section 9, presentation, demand, protest and all other notices of
any kind are hereby expressly waived by Seller.

        10.     MISCELLANEOUS.

        10.1.   PUBLICITY. Subject to the requirements of the Federal securities
laws, no publicity release or announcement concerning this Agreement or the
transactions contemplated hereby shall be issued without advance approval of the
form and substance thereof by Buyer and Seller jointly.

        10.2    NOTICES. All notices and other communications hereunder shall be
in writing and shall be deemed to have been given when delivered by hand or by
facsimile transmission, when telexed, or upon receipt when mailed by registered
or certified mail (return receipt requested), postage prepaid, to the parties at
the following addresses (or at such other address for a party as shall be
specified by like notice):

        (i)     If to Seller:

                Vyteris Holdings (Nevada), Inc.
                13-01 Pollitt Drive
                Fair Lawn, New Jersey 07410
                Attention: Chief Executive Officer
                Facsimile: (201) 796-6057

                With a copy (which copy shall not constitute notice) to:

                Lowenstein Sandler PC
                65 Livingston Avenue
                Roseland, New Jersey 07068
                Attention: Peter H. Ehrenberg, Esq.
                Facsimile: (973) 597-2400

        (ii)    If to Buyer:

                Spencer Trask Specialty Group, LLC
                535 Madison Avenue
                New York, NY  10022
                Attention: Bruno Lerer, Esq.
                Facsimile: (212) 486-7392

                With a copy (which copy shall not constitute notice) to:

                Littman Krooks LLP
                655 Third Avenue, 20th Floor
                New York, NY  10016
                Attention: Mitchell C. Littman, Esq.
                Facsimile: (212) 490-2990

        10.3.   ENTIRE AGREEMENT; EXERCISE OF RIGHTS. (a) This Agreement
(including the Schedules and Exhibits hereto) and the other Loan Documents (as
defined in Section 10.6

                                       12
<PAGE>

hereof) embody the entire agreement and understanding of the parties hereto with
respect to the subject matter hereof. No amendment of any provision of this
Agreement shall be effective unless it is in writing and signed by each of the
parties hereto and no waiver of any provision of this Agreement, nor consent to
any departure by either party from it, shall be effective unless it is in
writing and signed by the affected party, and then such waiver or consent shall
be effective only in the specific instance and for the specific purpose for
which given.

        (b)     No failure on the part of a party to exercise, and no delay in
exercising, any right under this Agreement, or any agreement contemplated
hereby, shall operate as a waiver hereof by such party, nor shall any single or
partial exercise of any right under this Agreement, or any agreement
contemplated hereby, preclude any other or further exercise thereof or the
exercise of any other right.

        10.4.   GOVERNING LAW. This Agreement shall be governed by and construed
in accordance with the laws of the State of New York applicable to agreements
made and to be performed entirely within such jurisdiction.

        10.5.   EXPENSES. Seller and Buyer shall, subject to the immediately
succeeding sentence, bear their respective expenses incurred in connection with
the negotiation, preparation, execution and performance of this Agreement and
the consummation of the transactions contemplated hereby, including, without
limitation, all fees and expenses of agents, representatives, counsel, brokers
or finders, and accountants.

        10.6    TRANSFERABILITY. Subject to securities laws restrictions of
general applicability, this Agreement, the Note, the Registration Rights
Agreement and the Warrant Agreement (collectively, the "Loan Documents") and all
rights hereunder and thereunder are freely and separately transferable and
assignable, in whole or in part, by Buyer. The foregoing transferees and
assignees shall be entitled to the rights provided in the Loan Documents. Seller
may not assign or delegate any of its obligations under the Loan Documents
without the prior written consent of Buyer. For purposes hereof, a sale or
exchange by Seller of all or substantially all of its assets shall constitute an
assignment/delegation requiring Buyer's prior written consent.

                            [SIGNATURE PAGE FOLLOWS]

                                       13
<PAGE>

        IN WITNESS WHEREOF, the parties hereto have executed this Note Purchase
Agreement on the date first above written.

                                   SPENCER TRASK SPECIALTY GROUP, LLC

                                   By: /s/ Donald F. Farley
                                       Name: Donald F. Farley
                                       Title: Chief Executive Officer

                                   VYTERIS HOLDINGS (NEVADA), INC.

                                   By: /s/ Timothy J. McIntyre
                                       Name: Timothy J. McIntyre
                                       Title: President & Chief Executive Office

                                   By: /s/ Michael McGuinness
                                       Name: Michael McGuinness
                                       Title: Chief Financial Officer

                                       14
<PAGE>

                                    EXHIBIT A

                                  Form of Note

<PAGE>

                                   EXHIBIT B

                            Form of Warrant Agreement

<PAGE>

                                    SCHEDULES

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