Document:

Confidentiality and Non-Competition Agreement with Jie Li

 Exhibit 10.4 
 Asiainfo Technologies (China) Limited 
 Confidentiality and Non-Competition Agreement

 Party A: Name: AsiaInfo Technologies (China) Limited 
 Address: Zhongdian Information Tower, No.6 Zhongguancun South Street, Haidian District, Beijing, P.R.China 
 Legal representative: Steve Zhang 
 Party B: Name: Jie Li 
 Address: 
 ID card No.: 
 Party A and Party B mutually recognize that Party B has the obligation to abide by certain information security and trade secret laws and regulations.
Party A and Part B acknowledge and agree that any such violation may be subject to liabilities under certain provisions of Chinese criminal laws, the relevant sections of which are attached hereto as Exhibit A. 
 Party A and Party B mutually recognize that Party B may have access to or become aware of the trade secrets of Party A and any Third Party during the
employment of Party B, and that the trade secrets of Party A and / or any Third Party have significant effect on their competitive advantages in the market. Party B acknowledges that, if the trade secrets of Party A and/ or any Third Party are not
effectively protected, the production and operations of Party A and / or any Third Party may be threatened, and the company may even sustain irrecoverable losses. Therefore, it is Party B’s obligation to keep the trade secrets of Party A and /
or any Third Party confidential. Party A and Party B also agree that Party B might have access to certain Third Party’s business operation system or telecommunications network and information during the employment, thus it is also Party
B’s obligation to strictly comply with any Third Party’s operation rules and protect telecommunications network and information security. In consideration of the foregoing, Party A and Party B hereby enter into this agreement in accordance
with the current applicable laws and regulations of the People’s Republic of China with respect to maintaining the confidentiality of the Trade Secrets of Party A by Party B and Party B’s certain non-competition obligations during the
period when Party B is employed by Party A and after Party B’s employment with Party A is terminated. 
  

	1.	General principles and definitions  

  

	 	1.1	In order to protect the legal rights and interests of both parties, the following principles shall apply to this agreement: this agreement should prevent any unfair competition
activities against Party A as well as to ensure that the Party B’s legal rights are fully protected. 

  

	 	1.2	The “Service Term” referred to in this agreement shall mean the period from the time when Party B commences to receive salary from Party A to the time of termination (or
extinguishment) of the labor relation between Party A and Party B. 

  

	 	1.3	A “Separation” referred to in this agreement shall mean that either party expressly indicates the intention to dissolve or terminate the employment relation and put such
intention into action, and shall comprise of all regular separations, such as resignation, dismissal, or dissolution or termination of the labor (contract) relation, and all irregular separations. 

	 	1.4	A “Third Party” referred in this Agreement shall mean any person or entity that is related to either Party A or Party B, including but not limited to Party A’s
customers, suppliers, business partners and Party B’s prior employers. 

  

	 	1.5	The “Trade Secrets” referred to in this Agreement shall mean any technical or operational information which are unknown to the public, and may generate economic benefits
for Party A and / or any Third Party, with practicability, and are subject to Party A and /or any Third Party’s confidentiality measures, regardless whether it is owned by Party A or any Third Party to whom Party A is subject to confidentiality
obligations and liabilities. Trade Secrets shall include but not be limited to: 

  

	 	1.5.1	items for which Party A has organized R&D or which are otherwise obtained by Party A, and which may have specific complete technical contents, or may constitute a technical
resolution for a product or technology and improvements thereof, or may be part of the technical elements of a certain product or technology, including but not limited to (1) software product designs currently owned, developed or conceived by
Party A and/ or any Third Party; (2) computer programs; (3) information and materials concerning the service projects currently owned, developed or conceived by Party A and/ or any Third Party; 

  

	 	1.5.2	the entirety or elements of Party A’s and / or any Third Party’s business strategies, forecasts, business and marketing plans, business operation scope and management
decision, various non-public information known by the company, project management, technical management, archive management, quality management methods, pricing methods, development plans, investment plans, operation rules, commercial network,
client name-lists, goods supply information, advertising planning, management experience, financial status, price lists, human resources planning, company structure information, internal rules and policies, business rules, bid prices and bid
documents, and other relevant resolutions, documents and letters, etc.; the data, documents, experimental reports, base stations distributed data and other information of Party A and /or any Third Party’s network planning and operation;

  

	 	1.5.3	Party A and /or any Third Party’s customer information, including but not limited to, customer database, call records, customers’ names, mobile numbers, passwords,
itemized bills, monthly bills, SIM card information, addresses, contact information and other customer information of similar nature; any electronic information included in Party A and /or any Third Party’s IT operation support systems,
databases, including but not limited to electronic documents, notices, data, internal materials, information and emails which are relevant to Party A and / or any Third Party’s Trade Secret; and 

  

	 	1.5.4	any information on Party A and / or any Third Party’s on-going or pending business dealings, including but not limited to draft agreements, performing agreements, or issues
involving customers’ claims, arbitrations or litigations, dispositions of assets or rights, etc. 

 Media and Form of
Trade Secret 
 The media and form of the Trade Secret include but not limited to letters, graphs and tables, video and electronic documents,
etc. which may be in written or verbal format. All Trade Secret shall be subject to this Agreement regardless whether it is marked confidential. 

	 	1.6	A “Competing Unit” referred to in this agreement shall mean any individual, company, enterprise, partnership, department, association, institutional unit, social entity or
other organization which engages in the same kind of business as Party A (including similar business), or provides the same kind of services as Party A, or constitutes an actual or potential competition against the business of Party A within the
territorial scope of Mainland China, Hong Kong, Macau, and Taiwan area. These competing units include but are not limited to the following: 

  

	 	1.6.1	An enterprise which is in the same industry as Party A; 

  

	 	1.6.2	An enterprise or organization of any other type (or in any other industry) which engages in any business identical or similar to the main services performed by Party B for Party A;

  

	 	1.6.3	A company, enterprise, or other organization which provides professional consultation or advisory services to the enterprises or organizations referred to in the preceding
paragraphs. 

  

	 	1.7	The “Non-competition Obligations” referred to in this agreement shall mean the obligations set forth in Article 4 of this agreement. 

  

	2.	Protection of Trade Secrets and Assignment of Intellectual Property Rights  

  

	 	2.1	Only designated individuals shall produce, receive and send, transfer, use, copy, excerpt, save and destroy the documents, materials and other items with the Trade Secret. Party B
may not access to those Trade Secret that are not necessary to fulfill his job responsibilities. Party B may not copy or excerpt any Trade Secret without authorization. Proper safety measures must be taken when receive and send, transfer and
retrieve the Trade Secret. 

 Unless authorized, Party B may not disclose the Trade Secret through any personal communications
and correspondences, nor discuss the Trade Secret in public, nor transfer Trade Secret by any other means. Party B shall obtain prior approval from Party A when disclose the Trade Secret during any business communications and cooperation
discussions. In case Party B realizes that the Trade Secret is inadvertently disclosed or is pending inadvertent disclosure, Party B shall immediately report to Party A and shall take remedial measures as instructed by Part A. 
 Party B agrees not to divulge, disclose, provide or disseminate, in any manner to any person or entity (including those employees of Party A, who may not
access to the Trade Secret according to Party A’s confidential policy) at any time, or utilize the Trade Secret improperly when performing his job duties, without Party A’s and / or any Third Party’s express written consent.

  

	 	2.2	Party B agrees to hold the Trade Secret confidential and not to use any Trade Secret after the termination of his employment with Party A in the same manner as if it was during the
Service Term. 

 All Party A and / or any Third Party’s Trade Secret, which are possessed or controlled by Party B,
including but not limited to equipment, CDs, magnetic disks, magnetic tapes, notebooks, memoranda, reports, archives, samples, books, correspondence, lists, other written and graphic records, or in any other forms, shall be Party A’s property.
Party B shall return the foregoing upon Party B’s Separation or Party A’s request. 

	 	2.3	Party B undertakes not to disclose the Trade Secrets of Party A and / or any Third Party under this agreement to any subsequent employer(s) of Party B. 

  

	 	2.4	Unless with Party A’s authorization and consent in writing, all the inventions made by Party B in connection with his/her own job, either separately or jointly with others,
during his/her Service Term, shall be owned by Party A. 

  

	 	2.5	Party B shall have the obligation to disclose to Party A all the intellectual property rights applied or obtained by Party B during the Service Term and within one year after Party
B’s Separation. 

  

	 	2.6	Party B undertakes that the intellectual property rights to the patents and all other intellectual properties accomplished by Party B in connection with his/her own job or
assignments at Party A within one year following his/her Separation from Party A shall be owned by Party A. 

  

	3.	Third-Party Procedures and Telecommunication Network and Information Security 

  

	 	3.1	During Party B’s Service Term, if Party B is engaged in any project assignments for a Third Party, Party B shall strictly abide by such Third Party’s rules and regulations
on safety, work process and confidentiality and privacy. 

  

	 	3.2	Unless and until upon written approval of Party A and / or the Third Party, Party B shall not access any Third Party’s product data, or add, delete, revise any data or program
in the Third Party’s system or software. 

  

	 	3.3	Party B agrees that Party B shall not take any non-work related individuals to the Third Party’s business location. 

  

	 	3.4	Party B may not engage in any behavior which might compromise Party B and / or the Third Party’s telecommunications network security and information security:

  

	 	3.4.1	Party B may not use Party A or any Third Party’s telecommunications networks to produce, copy, publish and transmit any information that are in violation of applicable Chinese
rules and regulations, including information that: 

 3.4.1.1 violates the fundamental principles of the
Chinese constitution; 
 3.4.1.2 be detrimental to state security, state secrecy, state power as well as national
unification; 
 3.4.1.3 impairs state honor and interests; 
 3.4.1.4 agitates ethnic hatred and discrimination, and jeopardizes ethnic solidarity; 
 3.4.1.5 violates state religious policies by promoting cult, feudalism and superstition; 
 3.4.1.6 spreads rumor and disturb social stability; 
 3.4.1.7 promotes obscenity, eroticism, gambling, violence, homicide and terror or the abetment of criminality; 
 3.4.1.8 insults or slander others or violate the legal right of others; and 
 3.4.1.9 any other contents that are prohibited by Chinese laws and regulations. 
  

	 	3.4.2	Party B may not engage in any activity that may endanger Party A and / or the Third Party’s telecommunications network security and information security, including but not
limited to: 

 3.4.2.1 deleting or modifying the functions of telecommunications networks or the data stored,
processed and transmitted and the application programs thereof; 
 3.4.2.2 stealing or destroying the information of others,
or carrying out any activities that are harmful to the lawful rights and interests of others by using Party A and / or the Third Party’s telecommunications networks; 

 3.4.2.3 producing, copying and transmitting computer viruses or attacking Party A and
/or any Third Party’s telecommunications networks and other telecommunications facilities; and 
 3.4.2.4 carrying out
other activities harmful to telecommunications network security and information security. 
  

	 	3.4.3	Party B may not disclose or use any information transmitted by Party A and / or the Third Party’s customers through the telecommunications network without proper authorization.

  

	 	3.4.4	Party B may not wiretap, copy, modify customers’ communication information, provide conveniences for others to wiretap, copy, modify customers’ communication information.

  

	 	3.4.5	Party B shall abide by Party’s A code of ethics. Party B may not misappropriate any resources available through Party A and / or the Third Party’s telecommunications
network including any customers’ numbers, card numbers, and passwords, etc. 

  

	4.	Non-competition clause  

  

	 	4.1	Party B undertakes not to engage in, for his/her own or on behalf of others, or participate in the operation of, any business which is competing with Party A directly or indirectly,
during his/her Service Term without Party A’s prior written consent. 

  

	 	4.2	During Party B’s Service Term, without Party A’s prior written consent, Party B undertakes that: it will not pursue a second occupation; it will not accept or acquire any
position (including but not limited to a position of partner, director, supervisor, shareholder, manager, staff member, agent, consultant, etc) in any Competing Unit or any other economic organization or social entity having direct economic relation
with Party A; it will not provide to such Competing Units with any advisory services (regardless whether with or without compensation) or any other assistance (such as engaging in any business the scope of which is identical or similar to the
business which Party A is currently undertaking or Party A may decide to develop from time to time); it will not make use of his/her position at Party A in order to obtain benefits by any improper means; it will not seek private interests for
himself/herself by utilizing his/her position and authority in Party A. 

  

	 	4.3	Upon Separation from Party A due to any reason, without the prior written consent of Party A, Party B shall not hold any position in any Competing Unit within the period to
which the economic compensation fee for non-competition paid by Party A is applicable. 

  

	 	4.4	Upon Separation from Party A due to any reason, without the prior written consent of Party A, Party B will not establish and manage, either directly or indirectly, any
enterprise which is in competition with Party A, within the period to which the economic compensation fee for non-competition paid by Party A is applicable, including but not limited to the establishment or management of: 

 

	 	4.4.1	an enterprise which is in the same industry as Party A; 

  

	 	4.4.2	an enterprise or organization of any other type (or in any other industry) which engages in any business identical or similar to the main services performed by Party B for Party A;
or 

  

	 	4.4.3	an enterprise, or other organization which provides professional consultation or advisory services to the enterprise or organization, referred to in the preceding paragraphs.

  

	 	4.5	At the time when Party B delivers a resignation notice to Party A or Party A delivers a dismissal notice to Party B, namely, upon termination or dissolution of the labor contract,
Party B shall have the obligation to notify Party A in writing of his/her true subsequent destination. During the non-competition period in which Party B enjoys the economic compensation fee, Party B shall have the obligation to notify Party A in
writing of his/her each new employer unit, position, and the business nature of the new employer unit. The time limit for notice shall be one week from the date of commencement of Party B’s employment at the new unit. 

 

	 	4.6	Party B agrees that, during his/her Service Term and within two years from his/her Separation from Party A, Party B warrants not to instigate, entice, encourage, solicit, or
otherwise attempt to affect, directly or indirectly, any other staff member of Party A for the purpose of leaving Party A and serving Party B or any other individual or entity; Party B warrants not to solicit Party A’s clients or pervious
clients for seizing their business and gaining direct or indirect benefits, with the exception of Party B’s activities for performance of his/her duties during the Service Term at Party A. 

  

	5.	Payment of compensation fee  

  

	 	5.1	Within one month after Party B’s Separation from Party A, Party A shall decide whether it requests Party B to undertake the Non-competition Obligation as well as the period of
non-competition. 

  

	 	5.2	If Party A decides to require Party B to undertake the Non-competition Obligation, it shall pay the non-competition compensation fee according to Article 5.3 of this agreement.

  

	 	5.3	The non-competition compensation fee shall be 50% of Party B’s annual salary (if the local government stipulates a minimum more than this amount, such minimum shall
prevail). The non-competition period to which such compensation fee is applicable shall be 12 months, commencing on the date of Party B’s Separation from Party A. 

  

	 	5.4	The non-competition compensation fee to Party B stipulated in this agreement is the total amount Party B deserved in the non-competition period, which shall be paid in one of the
following means: 

  

	 	5.4.1	a lump sum payment payable one month after Party B’s termination date; or 

  

	 	5.4.2	a monthly payment payable to Party B after Party B’s termination. Such payment is payable each month as long as Party B is subject to the non-competition provisions of this
Agreement. 

 The non-competition compensation fee shall be collected by Party B at Party A’s corporate address (or paid
by Party A to Party B via bank or post office). If Party B refuses to receive the payment, Party A may submit the payment of the compensation fee to the relevant authority for deposit according to law. The time when such submission is completed
shall be deemed to be the date of payment of the compensation fee. 
  

	 	5.5	If Party A fails to pay the non-competition compensation fee to Party B within one month after Party B’s Separation, Party A shall be deemed to have released Party B from
the Non-competition Obligation (which means that Party B may not be subject to the obligations set forth in and only in Articles 4.3 and 4.4). Upon such time, Party B shall not claim against Party A for payment of the non-competition compensation
fee in any manner (including but not limited to arbitration or litigation). 

	6.	Liabilities for breach of contract  

  

	 	6.1	If Party B is in breach of any of the provisions set forth in Articles 2.1, 3, 4.1 and 4.2, Party A shall be entitled to terminate the employment agreement immediately.

 If Party B is in breach of any of the provisions set forth in Articles 2.1, 2.2, 2.3, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.5 and
4.6 by way of non-performance or improper performance of his/her obligations, Party A will affix the administrative or civil liabilities on Party B in accordance with the relevant laws, regulations and corporate rules; where the circumstance is
serious, Party A will additionally petition the judicial authorities to investigate into Party B’s criminal liabilities. If Party A sustains any loss, Party B shall be liable for compensation. If it is difficult to calculate the amount of such
loss, the amount of compensation shall be the greater of (1) no less than 50% of the aggregate of Party B’s salary already paid by Party A and other expenses during the Service Term; or (2) RMB 300,000. If such compensation payment is
insufficient to pay for Party A’s actual damages, Party A reserves the right to recover liquidated damages from Part B. The payment of the default penalty shall not be intended as a dissolution or termination of Party B’s relevant
confidentiality obligation referred to above. 
  

	 	6.2	If Party B deliberately utilizes the trade secrets of Party A and/ or any Third Party or provides the trade secrets of Party A and/ or any Third Party to new employer unit or other
unit to use, develop, research and produce, and make profit on it, Party B and the secret using unit shall be jointly and severally liable to the loss of Party A and/ or any Third Party it there is any. 

  

	 	6.3	If Party A paid the non-competition compensation fee to Party B as per the provision of this agreement, and Party B did not perform the obligation of non-competition (i.e. Party B
failed to perform the obligation stipulated in Art. 4.3 and 4.4), Party B shall be liable to Party A as follows: Party B shall pay the default penalty to Party A in addition to the reimbursement of the total amount of the non-competition
compensation fee paid by Party A, and the amount of the default penalty shall be 50% of the non-competition compensation fee stipulated by this agreement. The reimbursement of the non-competition compensation fee and the payment of the default
penalty shall not intended as a weakening, dissolution or termination of Party B’s non-competition obligation. 

  

	 	6.4	During the period of existence of the labor relation between Party A and Party B, Party A may directly deduct the full or part of the amount from the salary, remuneration, bonus,
various compensation fees, and other income due and payable to Party B in order to recover Party A and or any Third Parties’ losses. The damages borne by Party B to Party A shall include but not be limited to the losses, direct and/or indirect,
tangible and/or intangible, property and/or non-property related, sustained by Party A and or any Third Parties due to Party B’s breach of contract, as well as the reasonable expenses incurred by Party A for investigation into Party B’s
breaching activities. 

  

	 	6.5	Whether this agreement terminates or not, Party A is entitled to claims against Party B for any loss sustained by Party A at any time if Party A has incurred any loss or Party A is
subject to any claims from any Third Party due to Party B’s infringement on the Trade Secret or violations of any Third Party’s operation procedures. After Party B compensates the loss sustained by Party A and / or any Third Party, Party B
shall continue to subject to this agreement. 

	7.	Termination of Non-competition Obligation  

 The
parties agree that Party B’s Non-competition obligation under Article 4 shall automatically terminate upon the occurrence of any of the following circumstances: 
  

	 	7.1	The non-competition period for Party B stipulated in this agreement expires; 

  

	 	7.2	Party A refuses to pay the non-competition compensation fee to Party B, or delays the due payment of the compensation fee for one month or more without justifiable cause; or

  

	 	7.3	Party A’s status as a legal person is terminated and there is no successors and assigns to its rights and obligations. 

  

	8.	Severability  

 The invalidity of any provision of
this agreement shall not affect the validity, legitimacy and enforceability of other provisions, and said invalid provision shall be replaced by another valid, legal, and enforceable provision which reflects the original intent of the parties to the
greatest extent. 
  

	9.	Notice  

  

	 	9.1	Notices may be delivered in person, or by courier (including commercial express delivery), registered mail, or public announcement. 

  

	 	9.2	Notices shall be delivered to the following addresses, unless modified by way of a prior written notice: 

 If to Party A: 
 Address: 
 Postal code: 
 Attention: 
 Telephone no.: 
 Facsimile no.: 
 If to Party B: 
 Address: 
 Postal code: 
 Attention: 
 Telephone no.: 
 Facsimile no.: 
 Email: 
  

	 	9.3	Notices or correspondence shall be deemed effectively given 

  

	 	9.3.1	upon the date on which the receiving party signs to acknowledge the receipt if delivered by courier (including commercial express delivery); or 

	 	9.3.2	seven (7) days after the date of issuance of the postal receipt by the post office if delivered by registered mail. 

  

	10.	Modification; waiver  

  

	 	10.1	This agreement may only be amended or modified with the mutual consent of both parties evidenced by a written document signed by them. 

  

	 	10.2	The consent, waiver, or change rendered by either party to this agreement with respect to a certain event shall only be applicable to that event, and shall not be presumed as the
approach of that party to any event of the same kind which may occur in the future, unless otherwise expressly indicated in writing. 

  

	 	10.3	Failure or delay to exercise any right under or related to this agreement by either party shall not be deemed as a waiver of such right. 

  

	11.	Related Parties  

  

	 	11.1	During the Service Term, Party B may have contact or become familiar with Trade Secrets of any of Party A’s related parties, or any individuals or entities related to Party
A’s related parties (including but not limited to customers, suppliers and business partners of Party A’s related parties). Party B shall be equally bound by this agreement with regards to the Trade Secret of Party A’s related
parties, or any individuals or entities that are related to Party A’s related parties, including any rules and regulations regarding third-party procedures. Party A and Party A’s related parties, may individually or collectively seek any
further damages that resulted from Party B’s violation of this agreement. 

  

	 	11.2	Party A’s related parties include, but not limited to: Lenovo AsiaInfo Technologies (Chengdu), Inc. and Beijing Star VATS Technologies Inc. (China). 

 

	12.	Signature  

  

	 	12.1	Each party acknowledges that it has carefully reviewed and fully understands the contents of all the provisions of this agreement and the legal implication of these contents. This
agreement shall become effective upon signature / seal of Party A’s authorized representative and Party B. 

  

	 	12.2	This agreement shall have two counterparts, each of which shall be held by each party respectively, and all of which shall have equal legal force. 

  

					
	Party A (Seal):	 	Party B:	 	 /s/ JIE LI

		
	Date of signature:	 	Date of signature: June 10, 2009

 (Seal of AsiaInfo Technologies (China), Inc)Warrant issued to Comerica Bank

 Exhibit 4.12 
 WARRANT 
 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF
1933, AS AMENDED (THE “1933 ACT”), OR ANY STATE SECURITIES LAWS. THIS WARRANT MAY NOT BE EXERCISED EXCEPT PURSUANT TO AN AVAILABLE EXEMPTION FROM SUCH REGISTRATION REQUIREMENTS. 
 THESE SECURITIES MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT (A) PURSUANT TO AN EFFECTIVE REGISTRATION THEREOF UNDER THE 1933 ACT AND IN
ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS, (B) TO THE COMPANY, (C) OUTSIDE THE UNITED STATES IN ACCORDANCE WITH REGULATION S UNDER THE 1933 ACT, (D) IN COMPLIANCE WITH THE EXEMPTION FROM THE REGISTRATION REQUIREMENTS UNDER THE
1933 ACT PROVIDED BY RULE 144 OR RULE 144A THEREUNDER, IF AVAILABLE, AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS, OR (E) IN A TRANSACTION THAT DOES NOT REQUIRE REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE LAWS.

  

	 Issuer Corporations: 
	NeuroMed Technologies Inc. (“NeuroMed Canada”), a corporation incorporated under the Yukon Business Corporations Act and 

 NeuroMed Pharmaceuticals Inc. (“NeuroMed US”), a corporation incorporated under the laws of Delaware 
  

	 Number of Option Securities 
	20,000 

  

	 Option Securities: 
	At the election of the Holder either of: 

  

	 	(a) at any time prior to the Exchange Time, Units (“Units”) consisting of: 

	 	        (i)   one (1) Exchangeable Share of NeuroMed Canada; and 

	 	        (ii)  one (1) Special Voting Share of NeuroMed Canada; and 

	 	        (iii) one (1) Common Special Voting Share of NeuroMed US; 

	 	- or - 

	 	(b) at any time after the Exchange Time, one (1) Common Share of NeuroMed US (an “Option Share”) 

  

	 	(each Unit or Option Share being hereinafter referred to as an “Option Security”) 

  

	 Initial Exercise Price: 
	U.S. $1.15 per Option Security (the “Initial Exercise Price”) 

  

	 Issue Date: 
	October 22, 2004 (the “Issue Date”) 

  

	 Expiration Date: 
	4:30 p.m. (Vancouver time), on the earlier of (the “Expiration Date”) October 22, 2009 and one (1) year after an initial public offering by a Company 

 THIS WARRANT CERTIFIES THAT, for good and valuable consideration, the receipt of which is hereby acknowledged, COMERICA BANK or its assignee (the
“Holder”) is entitled to purchase the number of fully paid and non-assessable Option Securities of NeuroMed Canada and NeuroMed US, as the case may be (individually a “Company” and collectively, the
“Companies”), subject to the provisions and upon the terms and conditions set out this Warrant. 

 ARTICLE 1 
 EXERCISE 
  

	1.1	Grant. The Companies hereby grant to the Holder the right to purchase in whole or in part, at any time and from time to time prior to the Expiration Date, the number
of Option Securities set out above at the Initial Exercise Price per Option Security as set forth above, and as adjusted pursuant to the terms of this Warrant (the “Warrant Price”). 

  

	1.2	Method of Exercise. The Holder may, at any time and from time to time, until the Expiration Date exercise this Warrant, in whole or in part, by delivering to the
office of either of the Companies set out in Section 4.5 of this Warrant: 

  

	 	(a)	a duly executed Notice of Exercise in substantially the form attached as Appendix 1; 

  

	 	(b)	if the Holder is exercising this Warrant to acquire Units, a copy of the Exchange Agreement duly executed by the Holder or a covenant to do so upon being provided by NeuroMed Canada
with a copy of the Exchange Agreement; and 

  

	 	(c)	unless Holder is exercising the cashless conversion right set out in Section 1.3, a certified cheque or bank draft for the aggregate subscription price for the Option
Securities so subscribed for. 

  

	1.3	Cashless Conversion Right. In lieu of exercising this Warrant in the manner specified in, Section 1.2, the Holder may, by delivering to the office of either of
the Companies as set out in Section 4.5, a duly executed Notice of Exercise in substantially the form attached as Appendix 1, at any time and from time to time until the Expiration Date, convert this Warrant, in whole or in part, into that
number of Option Securities determined by dividing (a) the aggregate Fair Market Value of the Option Securities in respect of which the Warrant is so being converted minus the product of the Warrant Price and the number of cash Option
Securities in respect of which the Warrant is so being converted by (b) the Fair Market Value of one Unit or one Common Share, as the case may be, for which this Warrant is then being exercised. 

  

	1.4	Repurchase on Acquisition. 

  

	 	(a)	“Acquisition.” For the purpose of this Warrant, “Acquisition” means any transaction or series of transactions resulting in:

  

	 	(i)	the sale, license, or other disposition of all or substantially all of the assets (including intellectual property) or business of either of the Companies; or

  

	 	(ii)	any reorganization, consolidation, amalgamation, arrangement, merger or other business combination involving either of the Companies and which results in holders of the voting
securities of either such Company outstanding before such transaction beneficially owning less than 50% of the outstanding voting securities of the surviving or successor entity after such transaction (other than as a result of the exercise of the
Exchange Rights or a mere re-incorporation or corporate continuance); or 

  

	 	(iii)	a take-over bid, tender offer, share exchange or other transaction whereby more than 50% of the outstanding voting securities of either of the Companies are acquired by any person
or one or more persons acting jointly or in concert (other than as a result of the exercise and the Exchange Rights). 

  

	 	(b)	 Assumption of Warrant. The Companies shall use their reasonable best efforts to cause the surviving or successor entity or offeror under an Acquisition to
assume in writing the obligations of this Warrant such that upon the closing or effective date of any Acquisition this Warrant will be exercisable or convertible so as to allow the Holder to acquire on exercise hereof the same securities, cash and
property as would be issuable or payable in consideration for the Option Securities issuable upon 

  

 2 

	 	 
exercise of the unexercised portion of this Warrant as if such Option Securities were outstanding on the closing or effective date of such Acquisition.

  

	 	(c)	Non-assumption. If upon the closing or effective date of any Acquisition the surviving or successor entity or offeror has not assumed in writing the obligations of this
Warrant as contemplated in Section 1.4(b) above, the Holder shall have the right to: 

  

	 	(i)	deem this Warrant to have been automatically converted pursuant to the cashless conversion right in Section 1.3 hereof immediately prior to the closing or effective date of
such Acquisition such that the Holder shall thereupon be entitled to participate in the Acquisition on the same terms as other holders of the Option Securities; or 

  

	 	(ii)	require either of the Companies to purchase this Warrant, for cash, payable as soon as practicable upon the closing or effective date of such Acquisition for an amount per Option
Security equal to two (2) times the Warrant Price in effect at such time. 

  

	1.5	Delivery of Certificate and New Warrant. Upon exercise or conversion of this Warrant in the manner contemplated herein, the person or persons in whose name or names;
the Option Securities issuable upon exercise of the Warrant are to be issued shall be deemed for all purposes to be the holder or holders of record such Option Securities and promptly upon the Holder exercising or converting this Warrant, the
Companies shall deliver or cause to be delivered to Holder certificates for the Option Securities acquired and, if this Warrant has not been fully exercised or converted and has not expired, a new Warrant representing the balance of the Warrant not
then exercised or converted. 

  

	1.6	Exchange of Warrants. At the option of the Holder, this Warrant may be surrendered to and exchanged at the registered office of either of the Companies for one or more
Warrant of a like tenor and aggregate number of Option Securities to which the exchanged Warrant is entitled. 

  

	1.7	Replacement of Lost or Mutilated Warrant. On receipt of evidence reasonably satisfactory to either of the Companies of the loss, theft, destruction or mutilation of
this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and amount to the Companies or, in the case of mutilation, on surrender and cancellation of this Warrant, the
Companies at its expense shall execute and deliver, in lieu of this Warrant, a new Warrant of like tenor, and the Holder shall be entitled to the same rights and benefits of the Warrant so lost, stolen or mutilated. 

  

	1.8	Exercise Restrictions. This Warrant may not be exercised unless an exemption from the registration requirements of the 1933 Act and all applicable state securities
laws is available and the Holder has delivered to the Companies an opinion of counsel reasonably satisfactory to the Companies to such effect; provided, however, that the original purchaser of this Warrant, and any affiliate of the original
purchaser to whom it assigns this Warrant, shall not be required to deliver an opinion of counsel in connection with its exercise of this Warrant if it confirms that the representations and warranties set forth in Section 3.5 of this Warrant
remain true and correct. 

 ARTICLE 2 
 EVENTS OF ADJUSTMENTS 
  

	2.1	 Reclassification, Exchange or Substitution. If at any time prior to the Expiration Date either of the Companies (a) declares or pays a dividend
or makes any other distribution of additional securities on any of the Underlying Securities or other securities convertible into or exchangeable or exercisable for Underlying Securities, (b) subdivides or redivides its outstanding Underlying
Securities into a greater number of shares, or (c) consolidates or combines its outstanding Underlying Securities into a lesser number of shares or there is any reclassification, recapitalization, substitution, capital reorganization or other
event resulting in a 

  

 3 

	 	 
change in the Underlying Securities, then in any such event, the Holder shall be entitled to receive, upon exercise or conversion of this Warrant, the number
and kind of securities or other property that the Holder would have received for the Underlying Securities if this Warrant had been exercised immediately before such reclassification, recapitalization, substitution, capital reorganization or other
event. If necessary as a result of such event, adjustments shall be made as nearly equivalent as may be practicable to the adjustments provided for in this Article 2 including, without limitation, adjustments to the Warrant Price and to the
number of Underlying Securities, securities or property issuable upon exercise of the Warrant. 

  

	2.2	Special Distributions. If at any time prior to the Expiration Date either of the Companies makes a distribution to all or substantially all of the holders of any of
the Underlying Securities of (i) shares of any class, other than securities, whether of either of the Companies or any other company, (ii) rights, options or warrants (other than rights, options or warrants exercisable by the holders
thereof within a period expiring not more than 30 days after the date of issue thereof), (iii) evidences of indebtedness, or (iv) cash securities or other property or assets, then, in each such case this Warrant shall represent the right
to receive, upon exercise or conversion of this Warrant, the number and kind of securities or other property that the Holder would have received for the Underlying Securities if this Warrant had been exercised immediately before such distribution.
If necessary as a result of such event, adjustments shall be made as nearly equivalent as may be practicable to the adjustments provided for in this Article 2 including, without limitation, adjustments to the Warrant Price and to the number of
Underlying Securities, securities or property issuable upon exercise of the Warrant. 

  

	2.3	Other Adjustments. The Board of Directors of the respective Company shall, in good faith, make any such other appropriate or equitable adjustment to the Warrant Price
or securities or property issuable upon the exercise or conversion thereof as may be necessary or desirable in respect of any transaction or event not expressly provided for in this Article 2. 

  

	2.4	Adjustments Successive. The adjustments provided for in this Article are cumulative, shall, in the case of any adjustment to the Exercise Price, be computed to the
nearest one-tenth of one cent, and in the case of any adjustment to the number of Underlying Securities purchasable upon exercise or conversion of this Warrant, be computed to the nearest one one-hundredth of one share of such Underlying Security,
as the case may be, and will apply (without duplication) to successive subdivisions, consolidations, distributions, issuances or other events resulting in any adjustment under the provisions hereof. 

  

	2.5	Fractional Shares. Notwithstanding Section 2.4, no fractions of Underlying Securities shall be issuable upon exercise or conversion of this Warrant and the number
of Underlying Securities to be issued shall be rounded down to the nearest whole Share. If a fractional share interest arises upon any exercise or conversion of this Warrant, the Companies shall, in lieu of such fractional interest, pay the Holder
an amount computed by multiplying the fractional interest by the Fair Market Value of such Underlying Security. 

  

	2.6	No Impairment. Neither of the Companies shall, by amendment of their respective Articles of Incorporation or other constating document or through a reorganization,
transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any other voluntary action, avoid or seek to avoid or frustrate the observance or performance of any of the terms to be observed or performed under this Warrant,
but shall at all times in good faith assist in carrying out all the provisions of this Article 2 and in taking all such action or making such adjustments as may be necessary, appropriate or equitable in the circumstances, acting reasonably, in
order to protect the Holder’s rights under this Article against impairment. 

  

	2.7	 Certificate as to Adjustments. Whenever there shall occur an event giving rise to an adjustment under this Article 2, the Companies at their
expense shall promptly compute such adjustment and furnish the Holder with a certificate signed by their respective Chief Financial Officer setting forth the adjustment and the facts upon which such adjustment is based. The Companies shall, upon
written request, furnish the Holder with a 

  

 4 

	 	 
certificate setting out the Warrant Price and Shares or other securities or other property issuable upon the exercise of this Warrant in effect upon the date
thereof and adjustments leading thereto. 

 ARTICLE 3 
 REPRESENTATIONS AND COVENANTS 
  

	3.1	Representations and Warranties of the Company. The Companies hereby jointly and severally represent and warrant to the Holder as follows: 

  

	 	(a)	any Underlying Securities which may be issued upon the exercise or conversion of this Warrant, and all securities, if any, issuable upon conversion or exchange of such Underlying
Securities, shall, upon issuance, be duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or under applicable Canadian provincial or US federal
and state securities laws; 

  

	 	(b)	the capitalization table for each of the Companies attached as Exhibit B to this Warrant is true and complete as of the Issue Date; 

  

	 	(c)	the Companies have obtained all such consents, authorizations or approvals as may be necessary in order to permit the issuance of this Warrant and to permit the Holder to exercise
the rights of conversion, exchange or purchase herein; and 

  

	 	(d)	neither the issuance of this Warrant or of the Underlying Securities issuable upon the exercise or conversion hereof or the purchase of this Warrant pursuant to Section 1.3
hereof will violate or contravene any agreement, pre-emptive right, indenture, agreement or other instrument to which either of the Companies is party or is bound. 

  

	3.2	Notice of Certain Events. If either of the Companies proposes at any time (a) to declare any dividend or distribution upon any of its outstanding shares, whether
in cash, property, shares, or other securities and whether or not a regular cash dividend; (b) to offer for subscription pro rata to the holders of any class or series of its shares any additional shares or securities of any class or series or
other rights; (c) to effect any reclassification or recapitalization any of its shares; (d) redeem or purchase any of its shares or other securities convertible or exchangeable into shares, except pursuant to the Exchange Rights; or
(e) amalgamate, merge, consolidate or combine its operations with or into any other corporation, (f) sell, lease, license, or convey all or substantially all of its assets or business, or (g) liquidate, dissolve, cease carrying on
business or wind up its business or affairs, then, in connection with each such event, the respective Company shall give the Holder (a) at least 20 days prior written notice of the date on which a record will be taken for the holders entitled
to receive such dividend, distribution, or subscription rights (and specifying the date on which the holders of such shares will be entitled thereto) or for determining rights to vote, if any, in respect of the matters referred to above; and in
addition, (b) at least 20 days prior written notice of the expected closing or effective date of any such recapitalization, reorganization, purchase, merger, sale, dissolution or other event. 

  

	3.3	Information Rights. The Company shall upon the written request of the Holder deliver to the Holder (a) copies of any notices of meeting, information circulars,
annual reports or other documents delivered to all the holders of any class of shares of the Companies, (b) the annual audited financial statements of the Companies for their most recently completed financial year, as certified by independent
public accountants of recognized standing, and (c) the quarterly unaudited financial statements of the Companies for their most recently completed quarterly financial period, provided however that the foregoing shall not apply if any of the
securities of such Company are listed and posted for trading on a recognized exchange in Canada or the United States or if such materials have otherwise been provided to the Holder. 

  

	3.4	Registration Under Securities Act of 1933, as amended. The Companies, agrees that the Underlying Securities shall be subject to the registration rights set forth in
Exhibit A. 

  

 5 

	3.5	Representations and Warranties of the Holder. The Holder represents and warrants to the Companies that: 

  

	 	(a)	it is an “accredited investor” within the meaning of Multilateral Instrument 45-103 — Capital Raising Exemptions of the Canadian Securities Administrators;

  

	 	(b)	it is an “accredited investor” as defined in Rule 501 promulgated under the 1933 Act; 

  

	 	(c)	it acquired the Warrant and if it exercises the Warrant, it will exercise the Warrant and acquire the Option Securities, for its own account, for investment purposes and not for the
account or benefit of any other person (except in the case of Comerica Incorporated, or another affiliate of Comerica Bank, which may have acquired and may exercise the Warrant for the account of Comerica Bank) or for distribution in violation of
any U.S. federal or state or Canadian provincial securities laws; 

  

	 	(d)	it acknowledges that the Warrant and the Underlying Securities have not been registered under the 1933 Act or any U.S. state or Canadian provincial securities laws, and that the
issuance of the Warrant and any issuance of Underlying Securities will be made to it in reliance upon exemptions from such registration requirements; and 

  

	 	(e)	it acknowledges that the Warrant is, and the Underlying Securities will be, “restricted securities” as defined in Rule 144 under the 1933 Act and that the Warrant is
subject to restrictions on exercise, and the Warrant is, and the Underlying Securities will be, subject to restrictions on transfer, pursuant to the 1933 Act and any applicable U.S. state or Canadian provincial securities laws.

 ARTICLE 4 
 MISCELLANEOUS 
  

	4.1	Legends. The certificate representing any Option Securities issued upon exercise of this Warrant, and any Underlying Securities issued upon exchange, conversion or
redemption of such Underlying Securities, and any certificates issued in exchange or in substitution therefor will, until no longer required under applicable securities laws, bear a legend in substantially the following form:

 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”), OR
ANY STATE SECURITIES LAWS. THESE SECURITIES MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT (A) PURSUANT TO AN EFFECTIVE REGISTRATION THEREOF UNDER THE 1933 ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS,
(B) TO THE COMPANY, (C) OUTSIDE THE UNITED STATES IN ACCORDANCE WITH REGULATIONS UNDER THE 1933 ACT, (D) IN COMPLIANCE WITH THE EXEMPTION FROM THE REGISTRATION REQUIREMENTS UNDER THE 1933 ACT PROVIDED BY RULE 144 OR RULE 144A
THEREUNDER, IF AVAILABLE, AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS, OR (E) IN A TRANSACTION THAT DOES NOT REQUIRE REGISTRATION UNDER THE 1933 ACT OR ANY APPLICABLE STATE LAWS, AND THE HOLDER HAS, PRIOR TO SUCH SALE, FURNISHED TO
THE COMPANY AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY. 
 and, if applicable, will bear a legend in substantially the following form:

 UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE THAT IS FOUR
(4) MONTHS AND A DAY AFTER THE LATER OF (1) OCTOBER 22, 2004, AND (2) THE DATE THE ISSUER BECAME A REPORTING ISSUER IN ANY PROVINCE OR TERRITORY OF CANADA. 
  

 6 

	4.2	Compliance with Securities Laws on Transfer. This Warrant and the Underlying Securities issuable upon exercise or conversion of this Warrant (and the securities
issuable, directly or indirectly, upon conversion or exchange of the Underlying Securities, if any) may not be transferred or assigned in whole or in part without compliance with applicable U.S. federal and state and Canadian provincial securities
laws by the transferor and the transferee (which may include, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Companies). 

  

	4.3	Transfer Procedure. Subject to the provisions of Section 4.2, the Holder may transfer all or part of this Warrant or the Underlying Securities issuable upon
exercise or conversion of this Warrant (or the securities issuable, directly or indirectly, upon conversion or exchange of the Underlying Securities, if any) by giving the Companies notice of the portion of the Warrant being transferred setting out
the name, address and taxpayer identification number of the transferee and surrendering this Warrant to the Companies for re-issuance to the transferee(s) (or Holder, if applicable); provided, however, that Holder may, at any time, transfer all or
part of this Warrant to its affiliates, including, without limitation, Comerica Incorporated and neither the Holder nor such affiliate shall be required to deliver an opinion of counsel in connection with any such transfer, provided that Holder
shall use commercially reasonable efforts to give notice of such transfer to the Companies and such affiliate shall then be entitled to all the rights of Holder under this Warrant and any related agreements, and the Companies shall cooperate fully
in ensuring that any Underlying Securities issued upon exercise of this Warrant shall be issued in the name of the transferee upon exercise of the Warrant. 

  

	4.4	Enurement. The terms and conditions of this Warrant shall enure to the benefit of, and be binding upon, the Companies and the holders hereof and their respective
permitted successors and assigns. 

  

	4.5	Notices. All notices and other communications from the Companies to the Holder, or vice versa, shall be deemed delivered and effective upon being given personally or
send by facsimile transmission or if mailed by first-class registered or certified mail, postage prepaid, on the date of mailing, at such address as may have been furnished to the Company or the Holder, as the case may be, in writing by the Company
or such Holder from time to time. All notices to the Holder shall be addressed as follows: 

  

			
	 Comerica Bank
 Attn: Warrant Administrator
 500 Woodward Avenue, 32nd Floor, MC 3379

Detroit, MI 48226
 Facsimile:
(313) 961-14777
	  	

 All notices to the Companies shall be addressed as follows: 
  

			
	 NeuroMed Technologies Inc.
 Suite 301, Don Rix Building
 2389 Health Sciences Mall, UBC
 Vancouver, B.C. V6T 1Z4
  
 Facsimile: (604) 822-9978
  
 Attention: Chief Financial Officer
	  	 NeuroMed Pharmaceuticals Inc.
 c/o Suite 301, Don Rix
Building
 2389 Health Sciences Mall, UBC
 Vancouver, B.C. V6T 1Z4

  
 Facsimile: (604) 822-9978
  
 Attention: Chief Financial Officer

  

	4.6	Amendments. This Warrant and any term hereof may be changed, waived, discharged or terminated only by an instrument in writing signed by the party against which
enforcement of such change, waiver, discharge or termination is sought. 

  

 7 

	4.7	Attorneys’ Fees. In the event of any dispute between the parties concerning the terms and provisions of this Warrant, the party prevailing in such dispute shall
be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys’ fees. 

  

	4.8	Governing Law. This Warrant shall be governed by and construed in accordance with the laws of British Columbia, without giving effect to its principles regarding
conflicts of law. 

  

	4.9	Currency. Any reference to “dollars” or “$ “ herein is to lawful currency of the United States. 

  

	4.10	Allocation of Warrant Price. On the exercise or conversion of this Warrant into Units, the Warrant Price shall be allocated as follows: 

  

	 	(a)	99.99% of the Warrant Price shall be allocated to the Exchangeable Share; 

  

	 	(b)	0.005% of the Warrant Price shall be allocated to the Special Voting Share; and 

  

	 	(c)	0.005% of the Warrant Price shall be allocated to the Common Special Voting Share, subject to adjustment in order to reflect any adjustment to the number of such Underlying
Securities under Article 2 hereof. 

  

	4.11	Definitions. 

  

	 	(a)	“Affiliates” has the meaning given to such term in the Securities Act (British Columbia); 

  

	 	(b)	“Common Shares” means the shares in the common stock of NeuroMed US as constituted as of the Issue Date; 

  

	 	(c)	“Common Special Voting Shares” means she shares of Common Special Voting Stock of NeuroMed US as constituted as of the Issue Date; 

  

	 	(d)	“Company” means NeuroMed Canada or NeuroMed US, as the case may be; 

  

	 	(e)	“Companies” means NeuroMed Canada and NeuroMed US; 

  

	 	(f)	“Exchangeable Shares” means common exchangeable shares of NeuroMed Canada as constituted as of the Issue Date; 

  

	 	(g)	“Exchange Agreement” means the exchange agreement dated October 30, 2003 between the Companies and the holders of the Underlying Securities of the Companies and
certain others, as amended from time to time; 

  

	 	(h)	“Exchange Rights” means the rights and obligations of the security holders and the Companies, as applicable, to exchange, convert or redeem exchangeable shares, Common
Special Voting Shares or Special Voting Shares for or into cash or other securities of the Companies pursuant to the terms of the constating documents of the Companies and the Exchange Agreement; 

  

	 	(i)	“Exchange Time” means the time at which there are no Exchangeable Shares outstanding other than Exchangeable Shares, if any, held by NeuroMed US and its Affiliates;

  

	 	(j)	“Fair Market Value”. The Fair Market Value of the Units or Common Shares shall be determined as follows: 

  

	 	(i)	if any of the securities comprising the Units or the Common Shares are listed and posted for trading on a recognized stock exchange or trading quotation system in Canada or the
United States, the Fair Market Value of such securities will be the numerical average of the closing price or if such exchange or system does not provide a closing price, the numerical average of the closing bid and ask prices of such securities, in
either case, for each of the five most recent days on which such securities have traded prior to the date upon which the Holder has delivered a Notice of Exercise pursuant to Section 1.2(a); and 

  

 8 

	 	(ii)	if any such securities are not so listed and traded, the Board of Directors of the respective Company shall forthwith and in good faith determine the fair market value of such
securities as of such date; 

  

	 	(iii)	“Special Voting Shares” means the Special Voting Shares of NeuroMed Canada as constituted as of the Issue Date; 

  

	 	(iv)	“Underlying Securities” means the Exchangeable Shares and Special Voting Shares, the Common Special Voting Shares and Common Shares; and 

  

	 	(k)	“Special Voting Shares” means the Special Voting Shares of NeuroMed Canada as constituted as of the Issue Date; 

  

	 	(l)	“Underlying Securities” means the Exchangeable Shares and Special Voting Shares, the Common Special Voting Shares and Common Shares; and 

  

	 	(m)	“Unit” means a unit consisting of the following securities of the Companies issuable upon exercise or conversion of this Warrant: 

  

	 	(i)	one (1) Exchangeable Share; 

  

	 	(ii)	one (1) Special Voting Share; and 

  

	 	(iii)	one (1) Common Special Voting Share. 

  

			
		 	NEUROMED TECHNOLOGIES INC.
		
		 	By:  /s/  Bruce
Colwill                                
		
		 	Name:  Bruce
Colwill                                
		
		 	Title:                            CFO          
                

  

 9 

  

			
		 	 NEUROMED PHARMACEUTICALS INC.

		
		 	By:  /s/  Bruce
Colwill                                
		
		 	Name:  Bruce
Colwill                                
		
		 	Title:                            CFO          
                

 Authorized signatories under Corporate Resolutions to Borrow or an authorized signer(s) under a resolution
covering Warrants must sign the Warrant. 
  

 10 

 APPENDIX 1 
 NOTICE OF EXERCISE 
 Capitalized terms in this Notice of Exercise have the meaning ascribed thereto in the attached
Warrant. 
 [Indicate which paragraph 1 or 2 below to apply.] 
  

	1.	Exercise. The undersigned hereby elects to purchase: 

  

	 	 ̈	at any time prior to the Exchange Time,
                                     Units (“Units”)
consisting of: 

  

	 	(i)	one (1) Exchangeable Share of NeuroMed Canada; and 

	 	(ii)	one (1) Special Voting Share of NeuroMed Canada; and 

	 	(iii)	one (1) Common Special Voting Share of NeuroMed US. 

  

	 	 ̈	at any time after the Exchange Time,
                                     Common Shares of Neuromed
US 

 pursuant to the terms of the attached Warrant, and tenders herewith payment of the Warrant Price for such securities, in full.

 - or - 
  

	2.	Cashless Conversion. With respect to
                                     of the Units or Common
Shares covered by the Warrant, as the case may be, the undersigned hereby elects to convert the attached Warrant into 

  

	 	 ̈	at any time prior to the Exchange Time., 6-aits (“Units”) consisting of: 

  

	 	(i)	one (1) Exchangeable Share of NeuroMed Canada; and 

	 	(ii)	one (1) Special Voting Share of NeuroMed Canada; and 

	 	(iii)	one (1) Common Special Voting Share of NeuroMed US. 

  

	 	 ̈	at any time after the Exchange Time, Common Shares of Neuromed US 

 pursuant to the cashless conversion rights specified in the Warrant. 
 Please issue a certificate or certificates representing the securities into
which such Warrants are exercised or converted in the name of the undersigned and deliver the certificate(s) to the following address, unless otherwise indicated under “Registration Instructions” or “Delivery Instructions” below:

 Comerica Bank 
 Attn: Warrant
Administrator 
 500 Woodward Avenue, 32nd Floor, MC 3379 
 Detroit, MI 48226 
 The undersigned represents and warrants to the Companies that: (i) it is acquiring the above securities solely for its own
account and not as a nominee for any other party and not with a view toward the resale or distribution thereof except in compliance with applicable securities laws; (ii) it is an “accredited investor” as defined in Rule 501
promulgated under the United States Securities Act of 1933, as amended; and (iii) the representations and warranties of the Holder set forth in Section 3.5 of the attached Warrant are true and correct with respect to the undersigned on the
date hereof. 
  

 1 

					
	 COMERICA BANK or its Assignee
	 		 	
			
	 	 		 	
	 (Signature)
	 		 	
			
	 	 		 	
	 (Date)
	 		 	
		 		 	
			
	 Registration Instructions (if different from above):
	 		 	Delivery Instructions (if different from above):
			
	 	 		 	 
	 Name
	 		 	Name
			
	 	 		 	 
	 Address
	 		 	Address
			
	 	 		 	 
	 Taxpayer Identification Number
	 		 	Taxpayer Identification Number
			
		 		 	

  

 2 

 EXHIBIT A 
 REGISTRATION RIGHTS 
 The Companies will use reasonable commercial efforts to allow any securities issued upon the
exercise of the Warrants to be registered as a “piggy back” registration in the first registered offering of the same class of securities for cash following (but not including) an initial public offering of such class or classes of
securities by either of the Companies, provided that the registration rights of the Holder (i) will not prevent the Company from granting any other registration rights, (ii) will be subordinate and subject to the terms of all other
existing and future registration rights granted by the Companies, (iii) will be subject to usual and customary terms and conditions, including, but not limited to, participation in any underwriting, underwriter’s right of partial or full
cutback and customary lock-up and indemnification provisions and (iv) will not be available in connection with a registration relating to compensatory benefit plans or business combinations or any registration on a form that does not include
substantially the same information as would be required to register the securities issued upon exercise of the Warrants. 
  

 A-1

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