Document:

<PAGE>

                                                                   EXHIBIT 10.14

                               SUBLEASE AGREEMENT

         THIS SUBLEASE (the "Sublease"), is made as of June 22, 1997, by and
between GENELABS TECHNOLOGIES, INC. ("Sublessor") and GENITOPE CORPORATION
("Sublessee"), in the following factual context:

         A.       Metropolitan Life Insurance Company (the "Master Lessor"), and
Sublessor entered into that certain Seaport Center Five-Year Industrial Net
Lease Agreement dated as of July 29, 1986, and as amended by (I) that certain
First Amendment to Industrial Net Lease Agreement dated as of March 23, 1987;
(II) that certain Second Amendment to Industrial Net Lease Agreement dated as of
September 4, 1987; (III) that certain Addendum to Second Amendment to Industrial
Net Lease Agreement dated as of March 15, 1988; (IV) that certain Third
Amendment to Five-Year Industrial Net Lease Agreement dated as of June 19, 1992;
(V) that certain Fourth Amendment to Five-Year Industrial Net Lease Agreement
dated as of June 17, 1997, (collectively, the "Master Lease"), covering
approximately 48,787 square feet of that certain building known as "Building 12"
of Seaport Center, which is located at 505 Penobscot Drive, Redwood City (the
"Master Lease Premises'). The Master Lease has been delivered to Sublessee prior
to or concurrently with the execution of this Sublease and is incorporated
herein by this reference.

         B.       Sublessor now desires to sublease approximately 5,168 square
feet of the Master Lease Premises (the "Premises") to Sublessee and Sublessee
desires to Sublease the Premises from Sublessor on the terms and conditions set
forth in this Sublease.

         NOW THEREFORE, the parties agree as follows:

         1.       SUBLEASE. Sublessor hereby subleases the Premises to Sublessee
and Sublessee hereby subleases the Premises from Sublessor on the terms and
conditions set forth in the Master Lease and in this Sublease. Sublessee shall
be allocated the use of nineteen (19) parking spaces. To the extent practicable
by Sublessor, said nineteen (19) spaces shall be located within the immediate
proximity of Sublessee's primary public entrance and shall include at least five
(5) "visitor" spaces. Possession of the Premises shall be given on or before
June 22, 1997. For the purposes of this Sublease, "commencement" shall be June
15,1997 or upon approval of Master Lessor, whichever is later.

         2.       INCORPORATION OF MASTER LEASE. Except as to provisions which
are specifically superseded by this Sublease, and as to Sections 1, 2, and 4 of
the Master Lease, each and every term, condition, and covenant contained in the
Master Lease is incorporated by reference into this Sublease if fully set forth
herein. As between Sublessor and Sublessee only, Sublessee hereby assumes and
agrees to perform each and every term, condition, and covenant which is an
obligation of the rights and remedies of the Master Lease and Sublessor shall
have each of the rights and remedies of the Master Lessor under the Master Lease
and Sublessee shall, under this Sublease, have as against the Sublessor each of
the rights and remedies of the Master Lessee. All capitalized terms not defined
in this Sublease shall have the meaning set forth in the Master Lease.

                                       1.
<PAGE>

         3.       TERM. The term of this Sublease (the "Term") shall commence on
the date first written above and, subject to approval by Master Lessor, shall
expire on June 14, 2000, unless sooner terminated pursuant to this Sublease or
the Master Lease.

         4.       RENT.

                  a.       Commencing on June 25, 1997, Sublessee shall pay to
Sublessor the amounts set forth in Table 1 ("Rental Schedule") per month as rent
for the Premises in advance on the first day of each calendar month during the
Term, without deduction or offset. In addition, commencing on July 1, 1997,
Sublessee shall pay to Sublessor concurrently with each monthly payment of rent
Sublessee's prospective pro rata share of all operating expenses, taxes,
insurance, utilities, and other charges incurred directly by Sublessor or
assessed by the Master Lessor pursuant to the Master Lease. All sums due to
Sublessor shall be deemed rent for the purposes of enforcing this Sublease. The
letter by Genelabs dated as of June 5, 1997, details the methods utilized by the
Sublessor in determining the operating expenses for the initial twelve (12)
months of this Sublease. Any addition or subtraction from this letter shall be
approved of in writing executed by Sublessor and Sublessee. Sublessee's
responsibility for operating expenses shall not include any expense previously
paid by Sublessor or incurred by Sublessor for any time prior to the date of
Sublessee's possession.

<TABLE>
<CAPTION>
                      TABLE 1: RENTAL SCHEDULE
------------------------------------------------------------------
<S>                                <C>
Months 1 to 6                      $2,440 per month thru Dec. '97
Months 7 to 18                     $7,235 per month thru Dec. '98
Months 19 to 30                    $7,493 per month thru Dec. '99
Months 31 to 36                    $7,752 per month thru June '00
</TABLE>

                  b.       With regards to the operating expenses, taxes,
insurance, utilities, and other charges assessed pursuant to the Master Lease
and this agreement, the charges will be estimated at the beginning of this
Sublease and at every twelve month anniversary for the duration of the Term. At
the end of each twelve month period, a statement will be provided by the
Sublessor to Sublessee detailing the actual costs incurred and showing the
Sublessee's actual pro rata share. Any variation from the estimated amount paid
by the Sublessee and the actual amount calculated at the end of each twelve
month anniversary will be either returned to Sublessee or due to Sublessor, as
appropriate, within 30 days of the presentation of said statement.

                  c.       Sublessor agrees to provide the Premises, at
Sublessee's prorated expense, with the same level and quality of general utility
service that Sublessor has for the Master Lease Premises (i.e. electricity, gas,
a proportionate use of Sublessor's outside refuse containers, and standard
domestic water service but excluding telephone and computer lines or services,
janitorial services, and any other services not explicitly described in this
paragraph). Sublessor will use its reasonable efforts to provide services to the
Premises, but assumes no responsibility in assuring or monitoring the quality
level of the services with respect to Sublessee's usage. Sublessee bears all
risks of using any services provided by Sublessor.

                                       2.
<PAGE>

                  d.       Sublessor agrees to maintain, at Sublessee's prorated
expense, the Premises' existing HVAC equipment, plumbing, and general electrical
wiring, to the same level and quality as that which it maintains for the Master
Lease Premises.

                  e.       Sublessee shall approve of the initial condition of
the Premises and the existing improvements therein in writing prior to July 22,
1997, or, otherwise be bound by the condition of the Premises as taken at the
time of possession. Sublessor shall timely replace or repair any condition in,
at, or affecting the Premises and/or the existing improvements which are listed
by Sublessee or otherwise known to Sublessor and which are inconsistent with
Sublessor's warranties of condition which are understood to be part of the
consideration of this Sublease.

         5.       USE. The Premises is to be used for general office, research
and development, sales, warehousing, laboratories, and related uses and for no
other purpose without prior written consent of Sublessor and subject to the
Master Lease.

         6.       ALTERATIONS.

                  a.       Sublessee shall not make or permit any alterations,
installations, additions or improvements, structural or otherwise in or to the
Premises (collectively, "Alterations" ) that require a permit or other
government approval or that require the approval of the Master Lessor, without
the prior written consent of Sublessor, which consent shall not be unreasonably
withheld or delayed (subject to approval by the Master Lessor). Sublessor agrees
not to withhold Sublessor's consent to any alteration which has been consented
to by the Master Lessor. All Alterations shall be done at the Sublessee's
expense, in accordance with plans and specifications approved by Sublessor and
the Master Lessor, and subject to all other reasonable conditions which the
Sublessor and the Master Lessor may impose.

                  b.       Excepting trade fixtures, equipment, machinery and
other personal property of the Sublessee's and except as provided in Section
6.c., all appurtenances, fixtures, improvements, additions or other property
attached to or installed in the Premises at the commencement of or during the
Term, whether temporary or permanent in nature, shall be and remain the property
of Sublessee during the Term, but shall be surrendered with the Premises at the
end of the Term without compensation to Sublessee.

                  c.       All furniture, furnishings, equipment, machinery,
counters, bookshelves, other cabinetry, and all other articles of movable
personal property installed in the Premises by or for the account of Sublessee,
without expense to Sublessor, and which can be removed without structural or
other material damage to the Premises ("Sublessee's Property") shall be and
remain the property of the Sublessee and may be removed by it at any time during
the Term. Prior to the expiration or termination of the Term, Sublessee shall
remove from the Premises all of Sublessee's Property except such items as the
parties shall have agreed in writing are to remain and to become the property of
Sublessor or the Master Lessor. Sublessee shall repair or pay the cost of
repairing any damage to the Premises resulting from such removal. Sublessee's
obligations under this section 6.c shall survive the expiration or earlier
termination of this Lease.

                                       3.
<PAGE>

         7.       MAINTENANCE AND REPAIR. Sublessee shall keep in good order,
condition and repair the Premises (as provided in section 12 of the Master
Lease); provided, however that Sublessor shall make any repairs which affect
portions of the Master Lease Premises beyond the Premises, and Sublessee shall
reimburse Sublessor for the cost of such repair (prorated in the event the
repair can equitably be charged to other occupants of the Master Lease Premises)
within thirty (30) days after receipt of written demand therefor. Sublessee
shall pay all costs for improvements, additions or alterations to the Premises,
as provided for in Section 12 of the Master Lease.

         8.       ASSIGNMENT OR SUBLEASING. Sublessee shall have no right to
assign this Sublease or further sublease the Premises without the written
consent of the Sublessor (and subject to the Master Lessor's approval and the
terms of the Master Lease), and that consent shall not be unreasonably withheld
and Sublessor, in good faith, will assist in seeking the Master Lessor's written
consent.

         9.       INSURANCE. Sublessee shall, at its sole cost and expense,
procure and maintain during the Term comprehensive general liability insurance
with a combined single limit for bodily injury, property damage and personal
injury liability of not less than $1,000,000 each occurrence and $1,000,000
general aggregate, and from insurance companies reasonably satisfactory to
Sublessor. Sublessor and the Master Lessor shall be named as additional insureds
on all such insurance policies. Sublessee shall also procure and maintain during
the Term at its sole cost and expense worker's compensation and employers'
liability insurance in amounts not less than $1,000,000 per accident for bodily
injury by accident, $1,000,000 policy limit for bodily injury by disease, and
$1,000,000 for each employee suffering from bodily injury by disease. Where this
paragraph 9 is in conflict with paragraph 20 of the Master Lease, this paragraph
shall control; otherwise, said paragraphs are to be read together. It is
understood that Sublessee is not directly or indirectly responsible for the
insurance covering Sublessor's improvements installed in the Premises or the
Master Lease Premises.

         10.      TERMINATION OF MASTER LEASE. This Sublease shall immediately
terminate if the Master Lease is terminated for any reason, whether voluntary or
involuntary. Notwithstanding anything to the contrary herein, or in the Master
Lease, Sublessee shall have the same rights as sublessor under the Master Lease
to terminate this Sublease for just cause consistent with Sublessor's rights
under the Master Lease. For example, if Sublessor has the option to terminate
the Master Lease due to an event of damage or destruction to the Premises, the
Sublessee shall have a similar right to terminate this Sublessee notwithstanding
the fact that Sublessor elects not to exercise such option with respect to any
other space subject to the Master Lease.

         11.      RIGHT TO CURE. If Sublessee shall at any time during the Term
fail to perform any of the obligations, conditions or covenants of this Sublease
or the Master Lease, Sublessor shall have the right, but not the obligation, to
immediately perform any such obligation, condition or covenant in order to
protect Sublessor's leasehold interest. In the event Sublessor suffers any cost
or expense as a result of such performance, Sublessee shall immediately
reimburse Sublessor for all such cost or expense, and any sum not paid within
ten (10) days after Sublessee receives written demand for reimbursement shall
bear interest at the highest interest rate allowed by law from the date of
expenditure by Sublessor to the date of reimbursement by Sublessee. Sublessor
agrees to notify Sublessee within ten (10) days if Sublessor receives notice
from

                                       4.
<PAGE>

Master Lessor that Sublessor is in default of any of its non-monetary
obligations, two (2) days in the event of a default of a monetary obligation,
under the Master Lease, along with an explanation of its course of action
intended to remedy any such default. Except as responsibility may be
specifically allocated to Sublessee under this Sublease, Sublessee shall have no
responsibility or obligation to cure any default by Sublessor under the Master
Lease unless such default arises out of the negligence or intentional act of
Sublessee.

         12.      SECURITY DEPOSIT. Concurrently with the execution of this
Sublease, the Sublessee has delivered to Sublessor a security deposit in the
amount of $7,500 (the "Security Deposit") as security for the full and faithful
performance of Sublessee's obligations under this Sublease. If at any time
during the Term, Sublessee shall be in default in the payment of rent or in
default for any other reason, Sublessor may apply all or part of the Security
Deposit for such payment or to cure such default. In such event, Sublessee shall
on demand restore the Security Deposit to its original amount. Upon expiration
or early termination of this Sublease, the Security Deposit shall be returned to
Sublessee, reduced by such amounts as may be required by Sublessor to remedy
defaults on the part of Sublessee in the payment of rent, defaults in
Sublessee's obligation to repair damage to the Premises, and to clean the
Premises if Sublessee has failed to do so. Any portion of the Security Deposit
not so required shall be paid over to Sublessee after expiration of the Term or
the earlier termination of this Sublease. Sublessor shall have no obligation to
segregate the Security Deposit from its general funds or to pay interest on the
Security Deposit.

         13.      SURRENDER. Sublessee shall, at the expiration of the Term or
upon sooner termination of this Sublease, surrender and return possession of the
Premises to Sublessor or the Master Lessor, as the case may be, in good
condition, broom clean, usual wear and tear excepted.

         14.      SUBLESSOR'S WARRANTY. Sublessor warrants that Sublessor is
current in all of its obligations, financial and otherwise, owed to the Master
Lessor and that Sublessor is not currently in default in any way under the
Master Lease. Sublessor also warrants to the best of its knowledge that the
Master Lessor owes Sublessor no unfulfilled obligation under the Master Lease on
the part of the Master Lessor to be performed and that the Master Lessor is not
in default under the Master Lease. Subject to the provisions of this Sublease,
Sublessee has examined the Premises and acknowledges that no representation or
warranties have been made regarding the Master Lease, the Master Lease Premises
or the Premises except as stated in this Sublease and its attachments.

         14.5.    PROPRIETARY TECHNOLOGY. The relationship of the parties under
this agreement is one of Sublessor and Sublessee only. In no event shall either
party, or any of its invitees, representatives, employees, agents, servants or
contractors, be deemed invitees, representatives, employees, agents, servants or
contractors of the other party. Neither party has any authority to bind or
obligate or incur any liability on behalf of the other, and no such authority
shall be implied. Absent a written agreement to the contrary, neither party or
any of its invitees, representatives, employees, agents, servants or contractors
shall have access to the other party's proprietary information, nor have any
right whatsoever to any present or future patent, copyright, trademark,
invention, trade secret or other intellectual property developed by the other
party.

                                       5.
<PAGE>

         15.      ATTORNEY'S FEES. If any legal action or any arbitration or
other proceeding is brought for the enforcement of this Sublease, or because of
an alleged dispute, breach, default or misrepresentation in connection with any
of the provisions of this Sublease, or relating to the underlying facts or the
surrounding circumstances, whether brought in contract or in tort, the
successful or prevailing party shall be entitled to recover reasonable
attorneys, fees and other costs, including expert witness fees and costs,
incurred in that action or proceeding, in addition to any other relief to which
it may be entitled. For the purposes of this Sublease, the term "prevailing
party" shall mean the party who obtains substantially the relief desired,
whether by dismissal, default, summary judgment, settlement, or otherwise.

         16.      NOTICES. All notices, requests, demands and other
communications under this Sublease shall be in writing and shall be personally
delivered or mailed by first class mail registered or certified, postage prepaid
to the party to whom the same is to be given at its address as follows:

                  Sublessor:        Genelabs Technologies, Inc.
                                    505 Penobscot Drive
                                    Redwood City, CA 94063
                                    ATTN: Director, Corporate Services

                  Copy to:          Lincoln Property Company
                                    101 Lincoln Center Drive
                                    Foster City, CA 94404-1167
                                    ATTN: Property Manager

                  Sublessee:        Genitope Corporation
                                    525 Penobscot Drive
                                    Redwood City, CA 94063
                                    ATTN: President & CEO

Notices, requests, demands and other communications under this Sublease shall be
effective only upon receipt. Either party may change its address for the
purposes of this Section 16 by giving the other party written notice of the new
address in the manner set forth above. Each party to this Sublease shall send to
the other party copies of any and all notices and other communications it shall
send to and receive from the Master Lessor. Notwithstanding the foregoing, in
the case of mailing, "receipt" shall be presumed on the third (3rd) day after
mailing.

         17.      MISCELLANEOUS.

                  a.       This Sublease is governed by the laws of the State of
California, and any question arising hereunder shall be construed or determined
to such law.

                  b.       Headings at the beginning of each numbered paragraph
of this Sublease are solely for the convenience of the parties and are not a
part of this Sublease.

                  c.       All provisions, whether covenants or conditions on
the part of Sublessee shall be deemed both covenants and conditions. All
recitals are deemed provisions and contractual in nature.

                                       6.
<PAGE>

                  d.       This Sublease may be amended in whole or in part only
be the mutual written agreement of the parties.

                  e.       This Sublease and the Master Lease as incorporated
herein by reference contain the entire agreement between the parties regarding
the sublease of the Premises and supersedes all prior agreements, whether
written or oral, between the parties regarding the same subject.

                  f'.      Nothing under this Sublease shall increase the
obligations of the Sublessee beyond those of the Sublessor's obligations under
the Master Lease. Any such increase is hereby agreed to be void.

                  f.       This Sublease may be signed in counterpart originals,
each of which shall be deemed an original and all of which shall, when executed,
constitute one and the same agreement.

                  g.       Subject to the limitations set forth in Section 8,
this Sublease shall be binding upon each of the parties and their respective
successors and assigns.

                  h.       In any instance in which this Sublease or the Master
Lease requires the consent of either Sublessor or the Master Lessor, the consent
of both Sublessor and Master Lessor shall be required.

                                       7.
<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Sublease as of the
day and year first written above.

                                      SUBLESSOR

                                      GENELABS TECHNOLOGY, INC.

                                      By: ______________________________________

                                      Title: ___________________________________

                                      Date: ____________________________________

                                      SUBLESSEE

                                      GENITOPE CORPORATION

                                      By: /s/ William R. Srigley
                                          --------------------------------------

                                      Title: President and CEO

                                      Date:6/24/97

                                       8.<PAGE>

                                                                   EXHIBIT 10.15

                     FOURTH AMENDMENT TO SUBLEASE AGREEMENT

         THIS FOURTH AMENDMENT TO SUBLEASE AGREEMENT ("Amendment") is entered
into, and dated for reference purposes, as of November 30, 2002 by and between
GENELABS TECHNOLOGIES, INC. (hereinafter referred to as "Sublessor") and
GENITOPE CORPORATION (hereinafter referred to as "Sublessee"), and is a fourth
amendment to the Sublease Agreement between the Sublessor and Sublessee dated as
of June 22, 1997 (the "Sublease"), with reference to the following facts:

                                    RECITALS

         A.       Sublessor and Sublessee entered into the Sublease for
approximately 5,168 square feet of office and R&D space expiring on June 14,
2000.

         B.       Sublessor and Sublessee entered into a certain "First
Amendment to Sublease Agreement" in October of 1999 extending the term of the
Sublease to expire on December 31, 2000.

         C.       Sublessor and Sublessee entered into a certain "Second
Amendment to Sublease Agreement" as of April 1, 2000 extending the term of the
Sublease to expire on May 31, 2001.

         D.       Sublessor and Sublessee entered into a certain "Third
Amendment to Sublease Agreement" as of September 1, 2000 extending the term of
the Sublease to expire on November 30, 2002.

         E.       Sublessor and Sublessee now desire to modify and amend the
Sublease to provide for an extension of the term.

         NOW THEREFORE, in consideration of the foregoing, and for other good
and valuable consideration, Sublessor and Sublessee agree that the Sublease
shall be and is hereby amended as of November 1, 2002 as follows:

         1.       EXTENSION OF TERM. To extend the Term of said Sublease with an
expiration date of November 30, 2006, unless sooner terminated pursuant to the
Sublease or the Master Lease.

         2.       RENT. The amount of monthly base rent due and payable by
Sublessee for the Premises shall he as follows:

<TABLE>
<CAPTION>
       PERIOD                              MONTHLY AMOUNT             MONTHLY RATE/SF
       ------                              --------------             ---------------
<S>                                        <C>                        <C>
12/01/2002-11/30/2003                        $10,852.80                   $ 2.10
12/01/2003-11/30/2004                        $11,178.38                   $2.163
12/01/2004-11/30/2005                        $11,514.30                   $2.228
12/01/2005-11/30/2006                        $11,860.56                   $2.295
</TABLE>

         3.       DEFINITIONS; OTHER TERMS. Unless otherwise set forth in this
Amendment, all capitalized terms shall have the meanings set forth in the
Sublease. Except as otherwise set forth herein, all other terms and conditions
of the Sublease and Master Lease will remain the same.

                                       1.
<PAGE>

         4.       MASTER LESSOR APPROVAL. This Amendment is subject to approval
by METROPOLITAN LIFE INSURANCE COMPANY (Master Lessor).

         5.       MASTER LEASE AMENDMENT. Sublessor has entered into a "Fifth
Amendment to Lease" with the Master Lessor. Sublessee hereby acknowledges that
it has received a copy of the Master Lease and all of its amendments, including
the "Fifth Amendment to Lease," and that this agreement is bound by the terms of
the Master Lease, as so amended. Notwithstanding anything in the Sublease or its
amendments to the contrary, the "Option to Extend" granted to Sublessor in
Section 11 of the Fifth Amendment shall not accrue to the benefit of Sublessee
and shall not be incorporated by reference into the Sublease, such that
Sublessee shall have no option to extend the Term of the Sublease beyond
November 30, 2006.

         6.       NO DEFAULT. Sublessor hereby certifies to Sublessee that as of
the date of execution of this Amendment that Sublessee is not in default under
the Sublease by reason of its failure to perform any obligations thereunder, and
that Sublessor is aware of no circumstance, event, condition, or state of facts
which, by the passage of time or the giving of notice, or both, could constitute
or result in such a default. Sublessee hereby certifies to Sublessor that as of
the date of execution of this Amendment that Sublessor is not in default under
the Sublease by reason of its failure to perform any obligations thereunder, and
that Sublessee is aware of no circumstance, event, condition, or state of facts
which, by the passage of time or the giving of notice, or both, could constitute
or result in such a default.

         7.       OPERATING EXPENSE EXCLUSIONS. Sublessee shall not be required
to pay any reasonably identifiable operating expenses that are incurred for the
sole benefit of Sublessor or that are the result of (i) a default by Sublessor
of any of its obligations under the Master Lease, or (ii) the negligence or
willful misconduct of Sublessor or any of its agents, employees, or contractors.

         8.       USE. Sublessee shall use the Premises for general offices,
research and development, sales, warehousing, laboratories, and light
manufacturing and for no other use without prior written consent of Sublessor
and subject to the Master Lease.

         9.       RIGHT OF FIRST OFFER. Sublessor hereby grants to Sublessee a
right of first offer to sublease the Premises if Sublessor exercises its "Option
to Extend" under the Fifth Amendment to Lease (the "Right of First Offer").
Notwithstanding the foregoing, such Right of First Offer shall be subordinate to
all rights of Sublessor to use and retain the Premises for its own benefit
following the expiration of the Term. Pursuant to the Right of First Offer
Sublessee shall have the right to sublease the Premises at a monthly base rent
per square foot to be negotiated. Sublessor shall notify Sublessee (a "First
Offer Notice") no later than the date which is six (6) months before the
expiration date of the Term if it has exercised and not subsequently revoked the
Option to Extend, provided that Sublessor does not wish to occupy the Premises
itself. If Sublessor either fails to exercise its Option to Extend, revokes its
Option to Extend or desires to occupy the Premises after the expiration of the
Term, Sublessee's Right of First Offer shall be of no further force and effect.
If Sublessee wishes to exercise Sublessee's Right of First Offer with respect to
the Premises, then within fifteen (15) days of delivery of such First Offer
Notice to Sublessee, Sublessee shall deliver notice to Sublessor of Sublessee's
intention to exercise its Right of First Offer with respect to the entire
Premises for the entire extended option term. If

                                       2.
<PAGE>

Sublessee does not so notify Sublessor within the fifteen (15) day period, then
Sublessor shall be free to lease the Premises to anyone to whom Sublessor
desires on any terms Sublessor desires. Notwithstanding anything to the contrary
contained herein, Sublessee must elect to exercise its Right of First Offer, if
at all, only with respect to the entire Premises and for the entire Option term,
and Sublessee may not elect to lease only a portion of the Premises. If
Sublessee does not exercise its Right of First Offer with respect to the
Premises or if Sublessee fails to respond to the First Offer Notice within
fifteen (15) days of delivery thereof, then Sublessee's Right of First Offer as
set forth herein shall terminate. If Sublessee timely delivers notice of its
exercise of its Right of First Offer with respect to the Premises, then, within
fifteen (15) days thereafter, Sublessor and Sublessee shall execute an amendment
to this Sublease extending the Term of the Sublease and modifying the monthly
base rent per square foot to the new negotiated rate. Other than the change in
monthly rent and the extension of the Term, the terms and conditions of this
Sublease shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the date first set forth above.

SUBLESSEE                                  GENITOPE CORPORATION

                                           By:/s/ Dan W. Denney, Jr.
                                              ----------------------------------

                                           Print Name: Dan W. Denney, Jr.

                                           Its: CEO
                                                --------------------------------
                                                             (Print Title)

SUBLESSOR                                  GENELABS TECHNOLOGIES, INC.

                                           By:/s/ Matthew M. Loar
                                              ----------------------------------
                                           Print Name: Matthew M. Loar
                                           Its: Chief Financial Officer
                                                --------------------------------
                                                             (Print Title)

                                       3.

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