Document:

ex4-1a

EXHIBIT 4.1(a)

THIS DOCUMENT CONSTITUTES PART OF A PROSPECTUS COVERING SECURITIES THAT HAVE
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933

GUILFORD PHARMACEUTICALS INC.

1993 EMPLOYEE SHARE OPTION AND RESTRICTED SHARE PLAN

AS AMENDED

      Guilford Pharmaceuticals Inc., sets forth herein the terms of this
Employee Share Option and Restricted Share Plan as follows:

      1. PURPOSE

      The Plan is intended to advance the interests of the Company by providing
eligible individuals (as designated pursuant to Section 5 below) with
incentives to improve business results, by providing an opportunity to acquire
or increase a proprietary interest in the Company, which thereby will create a
stronger incentive to expend maximum effort for the growth and success of the
Company, and will encourage such eligible individuals to continue to serve the
Company. To this end, the Plan provides for the grant of share options and
restricted shares all as set out herein. Each share option granted under the
Plan is intended to be an “incentive stock option” except (i) to the extent
that any such Option would exceed the limitations set forth in Section 8 below;
and (ii) for Options specifically designated at the time of grant as not being
“incentive stock options”.

      2. DEFINITIONS

      For purposes of interpreting the Plan and related documents (including
Share Option Agreements and Restricted Share Agreements), the following
definitions shall apply:

      2.1 “Affiliate” means any company or other trade or business that is
controlled by or under common control with the Company (determined in
accordance with the principles of Section 414(b) and 414(c) of the Code and the
regulations thereunder).

      2.2 “Agreement” means a written agreement between the Company and the
recipient individual that sets out the terms and conditions of the grant of an
Incentive Award.

      2.3 “Board” means the Board of Directors of the Company.

      2.4 “Code” means the Internal Revenue Code of 1986, as now in effect or as
hereafter amended.

 

      2.5 “Committee” means the stock option committee appointed by the Board
pursuant to Section 3.2 of the Plan.

      2.6 “Company” means Guilford Pharmaceuticals Inc..

      2.7 “Effective Date” means the date of adoption of the Plan by the Board.

      2.8 “Exchange Act” means the Securities Exchange Act of 1934, as now in
effect or as hereafter amended.

      2.9 “Exercise Price” means the Option Price multiplied by the number of
Shares purchased pursuant to the exercise of an Option.

      2.10 “Expiration Date” means the tenth (10th) anniversary of the grant
date, or, if earlier, the termination of the option pursuant to Section 20.3.

      2.11 “Fair Market Value” means the value of each Share subject to the Plan
determined as follows: if on the Grant Date or other determination date the
Shares are listed on an established national or regional stock exchange, are
admitted to quotation on the National Association of Securities Dealers
Automated Quotation System, or are publicly traded on an established securities
market, the Fair Market Value of the Shares shall be the closing price of the
Shares on such exchange or in such market (the highest such closing price if
there is more than one such exchange or market) on the trading day immediately
preceding the Grant Date or such other determination date (or if there is no
such reported closing price, the Fair Market Value shall be the mean between
the highest bid and lowest asked prices or between the high and low sale prices
on such trading day) or, if no sale of the Shares is reported for such trading
day, on the next preceding day on which any sale shall have been reported. If
the Shares are not listed on such an exchange, quoted on such System or traded
on such a market, Fair Market Value shall be determined by the Board in good
faith.

      2.12 “Grant Date” means the later of (i) the date as of which the Board
approves the grant and (ii) the date as of which the Optionee and the Company
or Subsidiary enter the relationship resulting in the Optionee being eligible
for grants.

      2.13 “Holder” means a person who holds Restricted Shares under the
Plan.

      2.14 “Incentive Award” means an award of an Option or Restricted Shares
under the Plan.

      2.15 “Incentive Share Option” means an “incentive stock option” within the
meaning of section 422 of the Code.

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      2.16 “Option” means an option to purchase one or more Shares pursuant to
the Plan.

      2.17 “Optionee” means a person who holds an Option under the Plan.

      2.18 “Option Period” means the period during which Options may be
exercised as defined in Section 12.

      2.19 “Option Price” means the purchase price for each Share subject to an
Option.

      2.20 “Plan” means the Guilford Pharmaceuticals Inc. Employee Share Option
and Restricted Share Plan.

      2.21 “Reporting Person” means a person who is required to file reports
under Section 16(a) of the Exchange Act.

      2.22 “Restricted Share Agreement” means the written agreement evidencing
the grant of Restricted Shares hereunder.

      2.23 “Restricted Share Award” means an award of the right to purchase
restricted Shares granted pursuant to Section 14 of this Plan.

      2.24 “1933 Act” means the Securities Act of 1933, as now in effect or as
hereafter amended.

      2.25 “Shares” mean share of common stock, par value $.01 per Share, of the
Company.

      2.26 “Share Option Agreement” means the written agreement evidencing the
grant of an Option hereunder.

      2.27 “Subsidiary” means any “subsidiary corporation” of the Company within
the meaning of Section 425(f) of the Code.

      3. ADMINISTRATION

      3.1 Board. The Plan shall be administered by the Board, which shall have
the full power and authority to take all actions and to make all determinations
required or provided for under the Plan or any Option granted or Share Option
Agreement entered into hereunder and all such other actions and determinations
not inconsistent with the specific terms and provisions

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of the Plan deemed by
the Board to be necessary or appropriate to the administration of the Plan or
any Option granted or Share Option Agreement entered into hereunder. The
interpretation and construction by the Board of any provision of the Plan or of
any Option granted or Share Option Agreement entered into hereunder shall be
final and conclusive.

      3.2. Committee The Board may from time to time appoint the Committee, and
the Board, in its sole discretion, may provide that the role of the Committee
shall be limited to making recommendations to the Board concerning any
determinations to be made and actions to be taken by the Board pursuant to or
with respect to the Plan, or the Board may delegate to the Committee such
powers and authorities related to the administration of the Plan, as set forth
in Section 3.1 hereof, as the Board shall determine, consistent with the
Restated Certificate of Incorporation and Bylaws of the Company and applicable
law. In the event that the Plan or any Option granted or Share Option
Agreement entered into hereunder provides for any action to be taken by or
determination to be made by the Board, such action may be taken by or such
determination may be made by the Committee if the power and authority to do so
has been delegated to the Committee by the Board as provided for in this
Section 3.2. Unless otherwise expressly determined by the Board, any such
action or determination by the Committee shall be final and conclusive.

      3.3. No Liability. No member of the Board or of the Committee shall be
liable for any action or determination made, or any failure to take or make an
action or determination, in good faith with respect to the Plan or any Option
granted or Share Option Agreement entered into hereunder.

      3.4. Action by the Board. The Board may act under the Plan with respect
to any Option granted to or Share Option Agreement entered into with an officer
or stockholder of the Company who is subject to Section 16 of the Exchange Act,
other than by, or in accordance with the recommendations of, the Committee,
constituted as set forth in Section 3.2 hereof, only if all of the members of
the Board are “disinterested persons” as defined in Rule 16b-3 of the Exchange
Act.

      4. SHARES

      The Shares that may be issued pursuant to Incentive Awards may be treasury
Shares or authorized but unissued Shares. The number of Shares that may be
issued pursuant to Incentive Awards under the Plan shall not exceed, in the
aggregate, 3,435,000 Shares. No more than 300,000 Shares may be issued
pursuant to Restricted Share Awards under the Plan. If any Incentive Award
expires, terminates, or is terminated or canceled for any reason prior to
exercise or vesting in full, the Shares that were subject to the unexercised,
forfeited, or terminated portion of such Incentive Award shall be available
immediately for future grants of Incentive Awards under the Plan.

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      5. ELIGIBILITY

      5.1 Designated Recipients. Subject to the next sentence, Incentive Awards
may be granted under the Plan to (i) any full-time employee of the Company or
any Subsidiary (including any such individual who is an officer or trustee of
the Company or any Subsidiary or Affiliate) as the Board shall determine and
designate from time to time or (ii) any other individual whose participation in
the Plan is determined by the Board to be in the best interests of the Company
and is so designated by the Board, provided that no outside director on the
Board shall be eligible to participate in this Plan.

      5.2 Successive Grants. An individual may hold more than one Incentive
Award, subject to such restrictions as are provided herein.

      6. EFFECTIVE DATE AND TERM OF THE PLAN

      6.1 Effective Date. The Plan shall be effective as of the date of
adoption by the Board, subject to approval of the Plan within one year of such
Effective Date by an affirmative majority vote of the stockholders, voting
either in person or by proxy, at a duly held meeting of the stockholders or by
written consent and in a manner that satisfies the requirements of Rule 16b-3
of the Exchange Act. Upon approval of the Plan by the stockholders of the
Company as set forth above, however, all Incentive Awards granted under the
Plan on or after the Effective Date shall be fully effective as if the
stockholders of the Company had approved the Plan on the Plan’s Effective Date.
If the stockholders fail to approve the Plan within one year of such Effective
Date, any Incentive Awards granted hereunder shall be null and void and of no
effect.

      6.2 Term. The Plan has no termination date, provided, however, that no
Incentive Share Option may be granted on or after the tenth anniversary of the
Effective Date.

      7. GRANT OF OPTIONS

      7.1 General. Subject to the terms and conditions of the Plan, the Board
may, at any time and from time to time, grant to such eligible individuals as
the Board may determine, Options to purchase such number of Shares on such
terms and conditions as the Board may determine, including any terms or
conditions which may be necessary to qualify such Options as Incentive Share
Options. Such authority specifically includes the authority, in order to
effectuate the purposes of the Plan but without amending the Plan, to modify
grants to eligible individuals who are foreign nationals or are individuals who
are employed outside the United States to recognize differences in local law,
tax policy, or custom.

      7.2 Limitation on Grants of Options to Executives. The maximum number of

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Shares subject to Options that can be awarded under the Plan to any executive
officer of the Company, a Subsidiary or any Affiliate, or to any other person eligible
for a grant of an Incentive Award under Section 5.1, is no more than one-third
of the total number of Shares that can be granted as Incentive Awards under the
Plan.

      8. LIMITATION OF INCENTIVE SHARE OPTIONS

      An Option (other than an Option described in exception (ii) of Section 1)
shall constitute an Incentive Share Option to the extent that the aggregate
fair market value (determined at the time the option is granted) of the Shares
with respect to which Incentive Share Options are exercisable for the first
time by any Optionee during any calendar year (under the Plan and all other
plans of the Optionee’s employer and its parent and Subsidiary) does not
exceed $100,000. This limitation shall be applied by taking Options into
account in the order in which they were granted.

      9. PARACHUTE LIMITATIONS

      Notwithstanding any other provision of this Plan or of any other
agreement, contract, or understanding heretofore or hereafter entered into by
the Optionee with the Company, except an agreement, contract, or understanding
hereafter entered into that expressly modifies or excludes application of this
paragraph (an “Other Agreement”), and notwithstanding any formal or informal
plan or other arrangement for the direct or indirect provision of compensation
to the Optionee (including groups or classes of participants or beneficiaries
of which the Optionee is a member), whether or not such compensation is
deferred, is in cash, or is in the form of a benefit to or for the Optionee (a
“Benefit Arrangement”), if the Optionee is a “disqualified individual,” as
defined in Section 280G(c) of the Code, any Option held by that Optionee and
any right to receive any payment or other benefit under this Plan shall not
become exercisable or vested (i) to the extent that such right to exercise,
vesting, payment, or benefit, taking into account all other rights, payments,
or benefits to or for the Optionee under this Plan, all Other Agreements, and
all Benefit Arrangements, would cause any payment or benefit to the Optionee
under this Plan to be considered a “parachute payment” within the meaning of
Section 280G(b)(2) of the Internal Revenue Code as then in effect (a “Parachute
Payment”) and (ii) if, as a result of receiving a Parachute Payment, the
aggregate after-tax amounts received by the Optionee from the Company under
this Plan, all Other Agreements, and all Benefit Arrangements would be less
than the maximum after-tax amount that could be received by him or her without
causing any such payment or benefit to be considered a Parachute Payment. In
the event that the receipt of any such right to exercise, vesting, payment, or
benefit under this Plan, in conjunction with all other rights, payments, or
benefits to or for the Optionee under any Other Agreement or any Benefit
Arrangement would cause the Optionee to be considered to have received a
Parachute Payment under this Plan that would have the effect of decreasing the
after-tax amount received by the Optionee as described in clause (ii) of the
preceding sentence, then the Optionee shall have the right, in the Optionee’s
sole discretion, to designate those rights, payments, or benefits under this
Plan, any Other Agreements, and any Benefit Arrangements that

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should be reduced or eliminated so as to avoid having the payment or benefit to the Optionee
under this Plan be deemed to be a Parachute Payment.

      10. SHARE OPTION AGREEMENTS

      All Options granted pursuant to the Plan shall be evidenced by Share
Option Agreements, to be executed by the Company and by the Optionee, in such
form or forms as the Board shall from time to time determine. Share Option
Agreements covering Options granted from time to time or at the same time need
not contain similar provisions; provided, however, that all such Option
Agreements shall comply with all terms of the Plan.

      11. OPTION PRICE

      The Option Price shall be fixed by the Board and stated in each Share
Option Agreement. The Option Price shall not be less than the Fair Market
Value of the Shares; provided, however, that in the event the Optionee would
otherwise be ineligible to receive an Incentive Share Option by reason of the
provisions of Sections 422(b)(6) and 424(d) of the Code (relating to stock
ownership of more than ten percent), the Option Price of an Option that is
intended to be an Incentive Share Option shall be not less than the greater of
par value or 110 percent of the Fair Market Value of a Share at the time such
Option is granted.

      12. TERM AND EXERCISE OF OPTIONS

      12.1 Term. Each Option granted under the Plan shall terminate and all
rights to purchase shares thereunder shall cease upon the expiration of ten
years from the date such Option is granted, or on such other date as may be
fixed by the Board and stated in the Share Option Agreement relating to such
Option; provided, however, that in the event the Optionee would otherwise be
ineligible to receive an Incentive Share Option by reason of the provisions of
Sections 422(b)(6) and 424(d) of the Code (relating to stock ownership of more
than ten percent), an Option granted to such Optionee that is intended to be an
Incentive Share Option shall in no event be exercisable after the expiration of
five years from the date it is granted.

      12.2 Option Period and Limitations on Exercise. Each Option granted under
the Plan shall be exercisable, in whole or in part, at any time and from time
to time over a period commencing on or after the Grant Date and ending upon the
expiration or termination of the Option, as the Board shall determine and set
forth in the Share Option Agreement relating to such Option. Without limiting
the foregoing, the Board, subject to the terms and conditions of the Plan, may
in its sole discretion provide that an Option may not be exercised in whole or
in part for a stated period or periods of time during which such Option is
outstanding; provided, however, that any such limitation on the exercise of an
Option contained in any Share Option Agreement may be rescinded, modified or
waived by the Board, in its sole discretion, at any time and from time to time
after the Grant Date of such Option, so as to accelerate the time at which the
Option may be exercised. Notwithstanding any other provisions of the Plan, no
Option shall

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be exercisable in whole or in part prior to the date the Plan is
approved by the stockholders of the Company as provided above.

      12.2A Retirement. If the Optionee retires from the Company or a
Subsidiary following the attainment of age 62 and (i) the Optionee has
completed at least five years but fewer than ten years of service with the
Company or a Subsidiary, the Optionee shall have the right (subject to the
limitations on exercise set forth in Section 3.7 below) to exercise all or any
part of the Option, to the extent the Option was vested upon the Optionee’s
retirement, for a period equal to the shorter of (a) five (5) years following
the Optionee’s retirement or (b) the remaining term of the Option, or (ii) the
Optionee has completed as least ten years of service with the Company or a
Subsidiary, the Optionee shall have the right (subject to the limitations on
exercise set forth in Section 3.7 below) to exercise all or any part of the
Option, to the extent the Option was vested upon the Optionee’s retirement, for
the remaining term of the Option.

      12.3 Termination of Employment. Upon the termination of the employment of
an Optionee with the Company, a Subsidiary or an Affiliate, other than by
reason of the death or “permanent and total disability” (within the meaning of
Section 22(e)(3) of the Code), any Option granted to an Optionee pursuant to
the Plan shall terminate, and such Optionee shall have no further right to
purchase Shares pursuant to such Option; provided further, that the Board may
provide, by inclusion of appropriate language in any Share Option Agreement,
that an Optionee may (subject to the general limitations on exercise set forth
in Section 12.2 above), in the event of termination of employment of the
Optionee with the Company, a Subsidiary or an Affiliate, exercise an Option, in
whole or in part, at any time subsequent to such termination of employment and
prior to termination of the Option pursuant to Section 12.2 above, either
subject to or without regard to any installment limitation on exercise imposed
pursuant to Section 12.2. above, as the Board, in its sole and absolute
discretion, shall determine and set forth in the Share Option Agreement.
Whether a leave of absence or leave on military or government service shall
constitute a termination of employment for purposes of the Plan, shall be
determined by the Board, which determination shall be final and conclusive.
For purposes of the Plan, a termination of employment with the Company, a
Subsidiary or an Affiliate shall not be deemed to occur if the Optionee is
immediately thereafter employed with the Company, any other Subsidiary or any
other Affiliate.

      12.4 Rights in the Event of Death. If an Optionee dies while employed by
the Company, a Subsidiary or an Affiliate, the executors or administrators or
legatees or distributees of such Optionee’s estate shall have the right
(subject to the general limitations on exercise set forth in Section 12.2
above), at any time within one year after the date of such Optionee’s death and
prior to termination of the Option pursuant to Section 12.1 above, to exercise
any Option held by such Optionee at the date of such Optionee’s death, whether
or not such Option was exercisable immediately prior to such Optionee’s death;
provided, however, that the Board may provide by inclusion of appropriate
language in any Share Option Agreement that, in the event of the death of an
Optionee, the executors or administrators or legatees or distributees of such

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Optionee’s estate may exercise an Option (subject to the general limitations on
exercise set forth in Section 12.2 above), in whole or in part, at any time
subsequent to such Optionee’s death and prior to termination of the Option
pursuant to Section 12.1 above, either subject to or without regard to any
installment limitation on exercise imposed pursuant to Section 12.2 above, as
the Board, in its sole and absolute discretion, shall determine and set forth
in the Share Option Agreement.

      12.5 Rights in the Event of Disability. If an Optionee terminates
employment with the Company, a Subsidiary or an Affiliate by reason of the
“permanent and total disability” (within the meaning of Section 22(e)(3) of the
Code) of such Optionee, then such Optionee shall have the right (subject to the
general limitations on exercise set forth in Section 12.2 above), at any time
within one year after such termination of employment and prior to termination
of the Option pursuant to Section 12.1 above, to exercise, in whole or in part,
any Option held by such Optionee at the date of such termination of employment,
whether or not such Option was exercisable immediately prior to such
termination of employment; provided, however, that the Board may provide, by
inclusion of appropriate language in any Share Option Agreement, that an
Optionee may (subject to the general limitations on exercise set forth in
Section 12.2 above), in the event of the termination of employment of the
Optionee with the Company, a Subsidiary or an Affiliate by reason of the
“permanent and total disability” (within the meaning of Section 22(e)(3) of the
Code) of such Optionee, exercise an Option, in whole or in part, at any time
subsequent to such termination of employment and prior to termination of the
Option pursuant to Section 12.1 above, either subject to or without regard to
any installment limitation on exercise imposed pursuant to Section 12.2 above,
as the Board, in its sole and absolute discretion, shall determine and set
forth in the Share Option Agreement. Whether a termination of employment is to
be considered by reason of “permanent and total disability” for purposes of
this Plan shall be determined by the Board, which determination shall be final
and conclusive.

      12.6 Limitations on Exercise of Option. Notwithstanding the foregoing
Sections, in no event may the Option be exercised, in whole or in part, prior
to the date the Plan is approved by the stockholders of the Company as provided
herein, or after ten years following the date upon which the Option is granted,
as set forth in Section 1 above, or after the occurrence of an event referred
to in Section 20.3 below which results in termination of the Option. In no
event may the Option be exercised for a fractional Share.

      12.7 Method of Exercise. An Option that is exercisable hereunder may be
exercised by the Optionee’s delivery to the Company of written notice of the
exercise and the number of Shares for which the Option is being exercised.
Such delivery shall occur on any business day, at the Company’s principal
office, addressed to the attention of the Board. Such notice shall specify the
number of Shares with respect to which the Option is being exercised and shall
be accompanied by payment in full of the Option Price of the Shares for which
the Option is being exercised. The minimum number of Shares with respect to
which an Option may be

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exercised, in whole or in part, at any time shall be the
lesser of (i) 100 shares or such lesser number set forth in the applicable
Option Agreement and (ii) the maximum number of Shares available for purchase
under the Option at the time of exercise. Payment of the Option Price for the
Shares purchased pursuant to the exercise of an Option shall be made (i) in
cash or in cash equivalents; (ii) through the tender to the Company of Shares,
which Shares shall be valued, for purposes of determining the extent to which
the Option Price has been paid thereby, at their Fair Market Value on the date
of exercise; or (iii) by a combination of the methods described in (i) and (ii).
The Board may provide, by inclusion of appropriate language in an Share Option Agreement,
that payment in full of the Option Price need not accompany the written notice
of exercise provided the notice of exercise directs that the Share certificate
or certificates for the Shares for which the Option is exercised be delivered
to a licensed broker acceptable to the Company as the agent for the individual
exercising the Option and, at the time such Share certificate or certificates
are delivered, the broker tenders to the Company cash (or cash equivalents
acceptable to the Company) equal to the Option Price for the Shares purchased
pursuant to the exercise of the Option plus the amount (if any) of federal
and/or other taxes which the Company may in its judgment, be required to
withhold with respect to the exercise of the Option. An attempt to exercise
any Option granted hereunder other than as set forth above shall be invalid and
of no force and effect. Promptly after the exercise of an Option and the
payment in full of the Option Price of the Shares covered thereby, the
individual exercising the Option shall be entitled to the issuance of a Share
certificate or Share certificates evidencing his or her ownership of such
Shares. Unless otherwise stated in the applicable Share Option Agreement, an
individual holding or exercising an Option shall have none of the rights of a
stockholder (for example, the right to receive cash or dividend payments
attributable to the subject Shares or to direct the voting of the subject
Shares) until the Shares covered thereby are fully paid and issued to him or
her. Except as provided in Section 20 below, no adjustment shall be made for
dividends or other rights for which the record date is prior to the date of
such issuance.

      13. TRANSFERABILITY OF STOCK

      13.1. Offer to the Company. In the Board’s sole discretion, the Board may
provide in a Share Option Agreement that an Optionee (or any other person who
is entitled to exercise an Option pursuant to the terms of the Plan) shall not
sell, pledge, assign, give, transfer or otherwise dispose of any Shares
acquired pursuant to an Option without first offering such Shares to the
Company for purchase on the same terms and conditions as those offered to the
proposed transferee. The Company may assign its right of first refusal, in
whole or in part, to (a) any stockholder of the Company (a “Stockholder”), (b)
any employee benefit plan (within the meaning of Section 3(3) of the Employee
Retirement Income Security Act of 1974, as amended) maintained by the Company
for the benefit of employees of the Company (a “Benefit Plan”) or (c) any
Affiliate. The Company shall give reasonable written notice to the Transferor
of any such assignment of its rights.

      13.2. Repurchase Rights. In the Board’s sole discretion, the Board may
provide

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in a Share Option Agreement that upon the termination of employment
with the Company of an employee who has been granted one or more Option(s)
hereunder, the Company shall have the right, for a period of six months
following such termination, to repurchase any or all of the Shares acquired by
the employee pursuant to such Option(s), at a price equal to the fair market
value of such Shares on the date of termination (or at such lower price as
shall have been specified by the Board and set forth in the applicable Share
Option Agreement(s)). In the event that the Company determines that it cannot
or will not exercise its right to purchase Shares pursuant to this Section
13.2, in whole or in part, the Company may assign its rights hereunder, in
whole or in part, to a Stockholder, a Benefit Plan or an Affiliate.
The Company shall give reasonable written notice to
the employee of any assignment of its rights. “Fair market value,” for purposes
of this Section 13.2, shall be determined by the Board in the same manner
specified for determining the Option Price pursuant to Section 2.11 hereof.

      13.3. Publicly Traded Shares. The restrictions of this Section 13 shall
terminate as of the first day that the Shares are listed on an established
national or regional stock exchange or is admitted to quotation on the National
Association of Securities Dealers Automated Quotation System, or is publicly
traded in an established securities market.

      13.4. Installment Payments. In the case of any purchase of Shares under
this Section 13, at the option of the Company or its permitted assignee, the
Company or its permitted assignee may pay the Optionee or other registered
owner of the Shares the purchase price in two or fewer annual installments.
Interest shall be credited on the installments at the applicable federal rate
(as determined for purposes of Section 1274 of the Code) in effect on the date
on which the purchase is made. The Company or its permitted assignee shall pay
at least one-half of the total purchase price each year, plus interest on the
unpaid balance, with the first payment being made on or before the 60th day
after the purchase.

      13.5. Legend Describing Restrictions and Obligations. In order to enforce
the restrictions on transferability imposed upon Shares under the Plan or as
provided in the Share Option Agreement, the Board shall cause a legend or
legends to be placed prominently on certificates representing Shares issued
pursuant to the Plan that complies with the applicable securities laws and
regulations and makes appropriate references to the restrictions imposed under
the Plan.

      14. GRANT OF RESTRICTED SHARES

      14.1 Restricted Share Awards.

            (a) The Board may from time to time, and subject to the provisions of the
Plan and such other terms and conditions as the Board may determine, grant
Restricted Share Awards under the Plan. Each Restricted Share Award shall be
evidenced by a written instrument which shall state the number of Shares
covered by the award and the terms

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and conditions which the Board shall have
determined with respect to such award, including the number of Shares that the
Holder shall be entitled to purchase, the price to be paid, and the time within
which the Holder must accept such offer, which shall in no event exceed thirty
(30) days from the date upon which the Board made the determination to grant
the Restricted Share Award. Upon the acceptance of each Restricted Share
Award, subject to Section 14.3, a certificate representing the Shares covered
by the award shall be registered in the name of the Holder and shall be
delivered to the Holder. The Holder shall generally have the rights and
privileges of a stockholder of the Company with respect to such Shares,
including the right to vote and to receive dividends, subject to the
restrictions specified in paragraphs (b) and (c).

            (b) The Board shall determine a period of time (“Limitation Period”) which
shall apply to the Shares transferred to a Holder with respect to each
Restricted Shares Award. Except as otherwise determined by the Board, during
the Limitation Period applicable with respect to each Restricted Shares Award,
the Holder may not sell, transfer, assign, pledge or otherwise encumber or
dispose of the Shares covered by such Restricted Shares Award. The Board in
its discretion may prescribe conditions for the incremental lapse of the
preceding restrictions during the Limitation Period, and for the lapse or
termination of such restrictions upon the occurrence of certain events before
the expiration of the Limitation Period. The Board in its discretion also may
shorten or terminate the Limitation Period or waive any conditions for the
lapse or termination of the restrictions with respect to all or any portion of
the Shares covered by the Restricted Shares Award. The certificate
representing the Shares distributed with respect to each Restricted Shares
Award made under the Plan shall be affixed with a legend setting forth the
restrictions applicable to the transfer of such Shares. The restrictions
applicable to a Restricted Shares Award shall lapse and a certificate for the
number of Shares with respect to which the restrictions have lapsed shall be
delivered to the Holder free of all such restrictions upon the earliest of the
following: (1) the expiration of the Limitation Period applicable to the
Restricted Shares Award, (2) the occurrence of an event prescribed by the Board
which results in the lapse of the restrictions, or (3) such other time as the
Board may determine.

            (c) The Shares covered by a Restricted Share Award shall be subject to a
repurchase option exercisable upon the voluntary or involuntary termination of
the Holder’s employment with the Company for any reason (including death or
disability) during the Limitation Period. The purchase price for Shares
repurchased pursuant to the Restricted Share Agreement shall be the original
price paid by the Holder plus interest paid by the Holder under any promissory
note given to the Company in payment of the orginal price and may be paid by
(i) check or (ii) cancellation of any indebtedness of the Holder to the Company
or a combination of (i) and (ii) so that the combined payment and cancellation
of indebtedness equals such repurchase price.

      14.2 Restricted Share Agreement. All Restricted Share Awards granted
pursuant to the Plan shall be evidenced by Restricted Share Agreements, to be
executed by the Company and by the Holder, in such form or forms as the Board
shall from time to time

- 12 -

determine. Restricted Share Agreements covering
Restricted Shares granted from time to time or at the same time need not
contain similar provisions; provided, however, that all such Restricted Share
Agreements shall comply with all terms of the Plan.

      14.3 Certificates for Restricted Shares. The Board may require that the
certificates evidencing the grant of a Restricted Share Award hereunder be held
in escrow until such restrictions have expired. The Board may also cause a
legend to be placed on such certificates that complies with the applicable
securities laws and regulations and makes appropriate reference to the
restrictions to which the Shares are subject. Upon attainment of the specified
objectives and requirements (or, to the extent specified in the grant, upon the
partial attainment of the objectives and requirements), a
certificate for the number of Shares with respect to which restrictions
have lapsed shall be delivered to the Holder free of restrictions.

      15. TRANSFERABILITY OF SHARES AND OPTIONS

      15.1 General. Except as provided in Section 15.2 with respect to
non-Incentive Share Options, during the lifetime of an Optionee, only such
Optionee or grantee (or, in the event of legal incapacity or incompetency, the
guardian or legal representative of the Optionee or grantee) may exercise the
Option. No Restricted Shares shall be assignable or transferable, other than
by will or the laws of descent and distribution, before the satisfaction of
applicable performance and service requirements with respect to such Shares, as
set forth in the applicable Restricted Share Agreement.

      15.2 Family Transfers. The Committee may, in its discretion, authorize
all or a portion of non-Incentive Share Options granted to an Optionee to be on
terms which permit transfer by such Optionee to (i) the spouse, children or
grandchildren of the Optionee (“Immediate Family Members”), (ii) a trust or
trusts for the exclusive benefit of such Immediate Family Members, or (iii) a
partnership in which such Immediate Family members are the only partners,
provided that (x) there may be no consideration for any such transfer, (y) the
Share Option Agreement pursuant to which such non-Incentive Share Options are
granted must be approved by the Committee, and must expressly provide for
transferability in a manner consistent with this Section, and (z) subsequent
transfers of transferred Options shall be prohibited except those in accordance
with Section 15.2 or by will or the laws of descent and distribution.
Following transfer, any such non-Incentive Share Options shall continue to be
subject to the same terms and conditions as were applicable immediately prior
to transfer, provided that for purposes of Sections 12.7 hereof the term
“Optionee” shall be deemed to refer the transferee. The events of termination
of employment of Section 12 hereof shall continue to be applied with respect to
the original Optionee, following which the non-Incentive Share Options shall be
exercisable by the transferee only to the extent, and for the periods specified
in Section 12.

      16. USE OF PROCEEDS

- 13 -

      The proceeds received by the Company from the sale of Shares pursuant to
the exercise of Options granted under the Plan shall constitute general funds
of the Company.

      17. REQUIREMENTS OF LAW

      The Company shall not be required to sell or issue any Shares under any
Incentive Award if the sale or issuance of such Shares would constitute a
violation by the Optionee, the Holder, the individual exercising the Option, or
the Company of any provisions of any law or regulation of any governmental
authority, including without limitation any federal or state securities laws or
regulations. If at any time the Company shall determine, in its discretion,
that the listing, registration
or qualification of any Shares subject to the Option upon any securities
exchange or under any governmental regulatory body, is necessary or desirable
as a condition of, or in connection with, the issuance or purchase of Shares
hereunder, the Option may not be exercised in whole or in part unless such
listing registration, qualification, consent or approval shall have been
effected or obtained free of any conditions not acceptable to the Company, and
any delay caused thereby shall in no way affect the date of termination of the
Option. Specifically in connection with the 1933 Act, at the time of grant of
Restricted Shares or when such Shares becomes vested or upon the exercise of
any Option, unless a registration statement under such act is in effect with
respect to the Shares covered by Option, the Company shall not be required to
sell or issue such Shares unless the Board has received evidence satisfactory
to it that the holder of such Restricted Shares or Option, may acquire such
Shares pursuant to an exemption from registration under such act. Any
determination in this connection by the Board shall be final, binding, and
conclusive. The Company may, but shall in no event be obligated to, register
any securities covered hereby pursuant to the 1933 Act. The Company shall not
be obligated to take any affirmative action in order to cause the exercise of
an Option or the issuance of Shares pursuant thereto or pursuant to a grant of
Restricted Shares to comply with any law or regulation of any governmental
authority. As to any jursdiction that expressly imposes the requirement that
an Option shall not be exercisable or that Shares may not be issued pursuant to
a Restricted Share Award unless and until the Shares covered by such grant or
Option are registered or are exempt from registration, the exercise of such
Option or issuance of Shares pursuant to such grant (under circumstances in
which the laws of such jurisdiction apply) shall be deemed conditioned upon the
effectiveness of such registration or the availability of such an exemption.

      18. AMENDMENT AND TERMINATION OF THE PLAN

      The Board may, at any time and from time to time, amend, suspend, or
terminate the Plan as to any Shares as to which Incentive Awards have not been
granted; provided, however, that no amendment by the Board shall, without
approval by the affirmative vote of stockholders who hold at least a majority
of the outstanding Shares of the Company entitled to vote thereon and who vote
in person or by proxy at a duly constituted stockholders’ meeting, cause the
Plan to not comply with the Code. The Company may retain the right in an
Agreement to cause a forfeiture

- 14 -

of the Shares or gain realized by a holder of
an Incentive Award on account of the holder taking actions in “competition with
the Company,” as defined in the applicable Agreement. Furthermore, the Company
may annul the grant of an Option, or Restricted Shares if the holder of such
grant was an employee of the Company or a Subsidiary and is terminated “for
cause,” as defined in the applicable Agreement. Except as permitted under this
Section 18 or Section 20 hereof, no amendment, suspension, or termination of
the Plan shall, without the consent of the holder of the Incentive Award, alter
or impair rights or obligations under any Incentive Award theretofore granted
under the Plan.

      19. EXCHANGE ACT: RULE 16b-3

      19.1. General. The Plan is intended to comply with Rule 16b-3 (“Rule
16b-3”) under the Exchange Act from and after the date on which the Corporation
first registers a class of
equity securities under Section 12 of the Exchange Act (the “Registration
Date”). From and after the Registration Date, any provision inconsistent with
Rule 16b-3 (as in effect on the Registration Date) shall, to the extent
permitted by law and determined to be advisable by the Board (constituted in
accordance with Section 19.2 hereof) or the Board (acting pursuant to Section
19.3 hereof), be inoperative and void. In addition, from and after the
Registration Date, the provisions set forth in Sections 19.2 through 19.5 shall
apply.

      19.2. Stock Option Committee. From and after the Registration Date, the
Committee appointed pursuant to Section 3.2 hereof shall consist of not fewer
than two members of the Board, neither of whom, during the period of service on
such Committee and the year prior to service on such Committee, shall have been
granted an Option under the Plan or been granted or awarded an option or other
security under any plan of the Corporation other than as permitted under Rule
16b-3(c)(2)(i) and each of whom shall qualify (at the time of appointment to
the Committee and during all periods of service on the Committee) in all
respects as a “disinterested person” as defined in Rule 16b-3.

      19.3. Action by the Board. From and after the Registration Date, the
Board may act under the Plan other than by, or in accordance with the
recommendations of, the Committee, constituted as set forth in Section 19.2
hereof, only if all members of the Board are “disinterested persons” as defined
in Rule 16b-3.

      19.4. Additional Restriction on Transfer of Shares. From and after the
Registration Date, no director, officer or other “insider” of the Corporation
subject to Section 16 of the Exchange Act shall be permitted to sell Shares
(which such “insider” had received upon exercise of an Option) during the six
months immediately following the grant of such Option.

      19.5. Additional Requirement of Stockholders’ Approval. From and after the
Registration Date, no amendment by the Board shall, without approval by a
majority of the votes cast at a duly held meeting of the stockholders of the
Corporation at which a quorum representing

- 15 -

a majority of all outstanding stock
is present, either in person or by proxy, and voting on the amendment, or by
written consent in accordance with applicable state law and the Certificate of
Incorporation and Bylaws of the Corporation, materially increase the benefits
accruing to Section 16 “insiders” under the Plan or take any other action that
would require the approval of such stockholders pursuant to Rule 16b-3.

      20. EFFECT OF CHANGES IN CAPITALIZATION

      20.1 Changes in Shares. If the number of outstanding Shares is increased
or decreased or the Shares are changed into or exchanged for a different number
or kind of Shares or other securities of the Company on account of any
recapitalization, reclassification, stock split, reverse split, combination of
Shares, exchange of Shares, Share dividend or other distribution payable in
capital stock, or other increase or decrease in such Shares effected without
receipt of
consideration by the Company, occurring after the closing of the initial
public offering of Shares of the Company, the number and kinds of Shares for
the issuance of which Restricted Share Awards may be granted and for the
acquisition of which Options may be granted under the Plan shall be adjusted
proportionately and accordingly by the Company. In addition, the number and
kind of Shares for which Restricted Share Awards or Options, are outstanding
shall be adjusted proportionately and accordingly so that the proportionate
interest of the holder of the Restricted Share Awards or Option immediately
following such event shall, to the extent practicable, be the same as
immediately before such event. Any such adjustment in outstanding Options
shall not change the aggregate Option Price payable with respect to Shares that
are subject to the unexercised portion of the Option outstanding but shall
include a corresponding proportionate adjustment in the Option Price per Share.

      20.2 Reorganization in Which the Company Is the Surviving Entity. Subject
to Section 20.3 hereof, if the Company shall be the surviving Entity in any
reorganization, merger, or consolidation of the Company with one or more other
entities, any Option theretofore granted pursuant to the Plan shall pertain to
and apply to the securities to which a holder of the number of Shares subject
to such Option would have been entitled immediately following such
reorganization, merger, or consolidation, with a corresponding proportionate
adjustment of the Option Price per Share so that the aggregate Option Price
thereafter shall be the same as the aggregate Option Price of the Shares
remaining subject to the Option immediately prior to such reorganization,
merger, or consolidation. Subject to any contrary language in the applicable
Restricted Share Agreement, any restrictions that were applicable to any
previously granted Restricted Share Award shall apply as well to any
replacement shares received by the Holder as a result of the reorganization,
merger, or consolidation.

      20.3 Reorganization in Which the Company Is Not the Surviving Entity or
Sale of Assets or Shares. Upon the dissolution or liquidation of the Company,
or upon a merger, consolidation, or reorganization of the Company with one or
more other entities in which the Company is not the surviving entity, or upon a
sale of substantially all of the assets of the

- 16 -

Company to another entity, or
upon any transaction (including, without limitation, a merger or reorganization
in which the Company is the surviving entity) approved by the Board that
results in any person or entity (or person or entities acting as a group or
otherwise in concert) owning 80 percent or more of the combined voting power of
all classes of securities of the Company, the Plan and all Options outstanding
hereunder shall terminate, except to the extent provision is made in writing in
connection with such transaction for the continuation of the Plan or the
assumption of such Options theretofore granted, or for the substitution for
such Options of new options covering the stock of a successor Company, or a
parent or subsidiary thereof, with appropriate adjustments as to the number and
kinds of shares and exercise prices, in which event the Plan and Options
theretofore granted shall continue in the manner and under the terms so
provided. In the event of any such termination of the Plan, each individual
holding an Option shall have the right (subject to the general limitations on
exercise set forth in Section 12.2 above), immediately before the occurrence of
such termination and during such period occurring before such termination as
the Board in its sole discretion shall
determine and designate, to exercise such Option in whole or in part,
whether or not such Option was otherwise exercisable at the time such
termination occurs. The Board shall send written notice of an event that will
result in such a termination to all individuals who hold Options not later than
the time at which the Company gives notice thereof to its stockholders but in
no event less than 30 days before the occurrence of such termination. Unvested
Restricted Share Awards shall be vested in the case of an event described in
this Section 20.3.

      20.4 Adjustments. Adjustments under this Section 20 related to Shares or
securities of the Company shall be made by the Board, whose determination in
that respect shall be final, binding, and conclusive. No fractional Shares or
units of other securities shall be issued pursuant to any such adjustment, and
any fractions resulting from any such adjustment shall be eliminated in each
case by rounding downward to the nearest whole share or unit.

      20.5 No Limitations on Company. The grant of Shares and Incentive Awards
pursuant to the Plan shall not affect or limit in any way the right or power of
the Company to make adjustments, reclassifications, reorganizations, or changes
of its capital or business structure or to merge, consolidate, dissolve, or
liquidate, or to sell or transfer all or any part of its business or assets.

      21. DISCLAIMER OF RIGHTS

      No provision in the Plan or in any Incentive Award granted or Agreement
entered into pursuant to the Plan shall be construed to confer upon any
individual the right to remain in the employ or service of the Company, any
Subsidiary or any Affiliate, or to interfere in any way with any contractual or
other right or authority of the Company, any Subsidiary or any Affiliate either
to increase or decrease the compensation or other payments to any individual at
any time, or to terminate any employment or other relationship between any
individual and the Company, a Subsidiary or an Affiliate. In addition,
notwithstanding anything contained in the Plan to the

- 17 -

contrary, unless
otherwise stated in the applicable Agreement, no Incentive Award granted under
the Plan shall be affected by any change of duties or position of the Optionee
or Holder (including a transfer to or from the Company, a Subsidiary or an
Affiliate), so long as such Optionee or Holder continued to be a trustee,
officer, consultant, employee, or independent contract (as the case may be) of
the Company, a Subsidiary or an Affiliate. The obligation of the Company to
pay any benefits pursuant to this Plan shall be interpreted as a contractual
obligation to pay only those amounts described herein, in the manner and under
the conditions prescribed herein. The Plan shall in no way be interpreted to
require the Company to transfer any amounts to a third party trustee or
otherwise hold any amounts in trust or escrow for payment to any participant or
beneficiary under the terms of the Plan.

      22. NONEXCLUSIVITY OF THE PLAN

      Neither the adoption of the Plan nor the submission of the Plan to the
stockholders of the Company for approval shall be construed as creating any
limitations upon the right and authority
of the Board to adopt such other incentive compensation arrangements
(which arrangements may be applicable either generally to a class or classes of
individuals or specifically to a particular individual or particular
individuals) as the Board in its discretion determines desirable, including,
without limitation, the granting of restricted shares or share options
otherwise than under the Plan.

      23. CAPTIONS

      The use of captions in this Plan or any Agreement is for the convenience
of reference only and shall not affect the meaning of any provision of the Plan
or such Agreement.

      24. WITHHOLDING TAXES

      24.1 Withholding. The Company shall have the right to deduct from
payments of any kind otherwise due to an Optionee any Federal, state, or local
taxes of any kind required by law to be withheld with respect to any Shares
issued upon the exercise of an Option under the Plan or with respect to the
termination of the Limitation Period with respect to Restricted Share Awards
under the Plan. At the time of exercise or termination of the Limitation
Period, the Optionee or Holder shall pay to the Company any amount that the
Company may reasonably determine to be necessary to satisfy such withholding
obligation. Subject to the prior approval of the Company, which may be
withheld by the Company in its sole discretion, the Optionee or Holder may
elect to satisfy such obligations, in whole or in part, (i) by causing the
Company to withhold Shares otherwise issuable pursuant to the exercise of an
Option or (ii) by delivering to the Company Shares already owned by the
Optionee or Holder. The Shares so delivered or withheld shall have a fair
market value equal to such withholding obligations. The fair market value of
the Shares used to satisfy such withholding obligation shall be determined by
the Company as of the date that the amount of tax to be withheld is to be
determined. An Optionee or

- 18 -

Holder who has made an election pursuant to this
Section 24.1 may only satisfy his or her withholding obligation with Shares
that are not subject to any repurchase, forfeiture, unfulfilled vesting, or
other similar requirements.

      24.2 Limitations for Reporting Person. Notwithstanding the foregoing, in
the case of a Reporting Person, no election to use Shares for the payment of
withholding taxes shall be effective unless made in compliance with any
applicable requirements under Rule 16b-3(e) or any successor rule under the
Exchange Act.

      25. OTHER PROVISIONS

      Each Incentive Award granted under the Plan may contain such other terms
and conditions not inconsistent with the Plan as may be determined by the
Board, in its sole discretion.

      26. NUMBER AND GENDER

      With respect to words used in this Plan, the singular form shall include
the plural
form, the masculine gender shall include the feminine gender, etc., as the
context requires.

      27. SEVERABILITY

      If any provision of the Plan or any Agreement shall be determined to be
illegal or unenforceable by any court of law in any jurisdiction, the remaining
provisions hereof and thereof shall be severable and enforceable in accordance
with their terms, and all provisions shall remain enforceable in any other
jurisdiction.

      28. GOVERNING LAW

      The validity and construction of this Plan and the instruments evidencing
the Incentive Awards granted hereunder shall be governed by the laws of the
State of Maryland.

- 19 -ex4-1b

EXHIBIT 4.1(b)

SHARE OPTION AGREEMENT

            This SHARE OPTION AGREEMENT (this “Agreement”) is effective as of the 15th
day of November 2000, by and between Guilford Pharmaceuticals Inc., a Delaware
Corporation (the “Company”) and Susan M. Smith, a resident of the State of
Maryland (the “Optionee”).

W I T N E S S E T H:

            WHEREAS, the Optionee has entered into a Consulting Agreement with the
Company (the “Consulting Agreement”) pursuant to which the Optionee is
performing consulting services for the Company in consideration for, among
other things, an option (the “Option”) to purchase a certain number of shares
of the common stock of the Company, par value $0.01 per share (the “Shares”).

            WHEREAS, in accordance with the terms of the Consulting Agreement, this
Agreement sets forth the terms and conditions of the Optionee’s Option.

            NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, the parties hereto do hereby agree as follows:

1. GRANT OF OPTION.

            The Company hereby grants to the Optionee the Option to purchase from the
Company, on the terms and subject to the conditions hereinafter set forth,
8,000 Shares. The “Date of Grant” of this Option is November 14, 2000, the
date on which the grant of the Option was approved by the Board of Directors of
the Company.

2. PRICE.

            The purchase price (the “Option Price”) for the Shares subject to the
Option granted by this Option Agreement is $16.0625 per Share.

3. EXERCISE OF OPTION.

      3.1 Time of Exercise of Option.

            Except as otherwise provided herein, the option granted pursuant to this
Option Agreement shall be subject to exercise as follows:

			
	 	(i)	On the date of this Agreement, the Option shall
be exercisable in respect of 2,331 Shares;
	 

	 	(ii)	On the first day of each calendar month
commencing on December 1, 2000, and continuing until March 1,
2002, the Option shall be exercisable in respect of 333
Shares; and
	 

	 	(iii)	On April 1, 2002, the Option shall be exercisable in respect of 341
Shares.

      3.2 Exercise by Optionee.

            During the lifetime of the Optionee, only the Optionee (or, in the event
of the Optionee’s legal incapacity or incompetency, the Optionee’s guardian or
legal representative) may exercise the Option.

      3.3 Death.

            In the event of the Optionee’s death, the personal representative or
legatees or distributees of the Optionee’s estate, as the case may be, shall
have the right (subject to the limitations on exercise set forth in Section 3.5
below) to exercise all or any part of the Option, whether or not the Option was
exercisable on the date of the Optionee’s death, at any time within one (1)
year after the date of the Optionee’s death and prior to the termination of the
Option as set forth in Subsection 3.4 of this Section.

      3.4 Termination of Option.

            The Option shall terminate upon the expiration of a period of ten years
from the Date of Grant of the Option, as set forth in Section 1 above.

      3.5 Limitations on Exercise of Option.

            Notwithstanding the foregoing Subsections of this Section, the Option may
not be exercised, in whole or in part, after ten years following the Date of
Grant of the Option, as set forth in Section 1 above, or after the occurrence
of an event referred to in Section 8 below which results in termination of the
Option. In no event may the Option be exercised for a fractional Share.

      3.6 Securities Act.

            The Optionee understands that (i) as of the date of this Agreement the
Shares that are the subject of the Option have not been registered under the
Securities Act of 1933 (as now in effect or as hereafter amended, the
“Securities Act”), (ii) the Shares held by Optionee as a result of any exercise
of the Option, must be held indefinitely unless a subsequent disposition
thereof is registered under the Securities Act or is otherwise exempt from
registration, (iii) such Shares will bear a legend to that effect, and (iv) the
Company will make a notation on its transfer books to that effect.

      3.7 Investment Representations.

            The Optionee represents that (i) she is an “accredited investor” within
the meaning of Rule 501 of the Securities Act, (ii) upon any exercise of the
Option, the Shares represented thereby are being acquired for her own account
for the purpose of investment and not with a view to or for sale in connection
with any distribution thereof, except to the extent that such Shares are
included in a registration statement filed with the Securities and Exchange
Commission under the Securities Act.

2

4. VESTING UPON A CHANGE OF CONTROL

      4.1 Vesting Upon a Change in Control

            Notwithstanding any other provision of this Agreement, in the event of a
“Change in Control” (as defined below), any unvested Options granted hereunder
shall be accelerated and be fully vested as of the date immediately prior to
the effective date of the Change in Control.

      4.2 Definition of “Change in Control”.

            A “Change in Control” shall be deemed to have occurred if: (i) any
“person” (including, without limitation, any individual, sole proprietorship,
partnership, trust, corporation, association, joint venture, pool, syndicate,
or other entity, whether or not incorporated), or any two or more persons
acting as a syndicate or group or otherwise acting in concert with regard to
the ownership of securities of the Company and thereby deemed collectively to
be a “person”) as such term is used in Sections 13(d) and 14(d) of the
Securities Exchange Act of 1934, as amended (the “Exchange Act”), becomes,
after the date hereof, the “beneficial owner” (as defined in Rule 13d-3 under
the Exchange Act), directly or indirectly, of securities of the Company
representing thirty percent (30%) or more of the combined voting power of the
Company’s then outstanding securities, unless, in transaction in which a
“person” becomes, after the date hereof, the “beneficial owner” (as defined in
Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of
the Company representing less than fifty percent (50%) of the combined voting
power of the Company’s then outstanding securities, prior to the acquisition by
such person of securities of the Company which causes such person to have such
beneficial ownership, the full Board shall by at least a two-thirds vote have
specifically approved such acquisition and determined that such acquisition
shall not constitute a Change in Control despite such beneficial ownership; or
(ii) during any two (2) year period, individuals who at the beginning of such
period constitute the Board, together with any new directors elected or
appointed during the period whose election or appointment resulted from a
vacancy on the Board caused by the retirement, death, or disability of a
director and whose election or appointment was approved by a vote of at least
two-thirds (2/3rds) of the directors then still in office who were directors at
the beginning of the period, cease for any reason to constitute a majority
thereof.

5. METHOD OF EXERCISE OF OPTION.

            Subject to the terms and conditions of this Agreement, the Option may be
exercised by delivering written notice of exercise to the Company, at its
principal office, addressed to the attention of the Committee, which notice
shall specify the number of Shares for which the Option is being exercised, and
shall be accompanied by payment in full of the Option Price of the shares for
which the Option is being exercised. Payment of the Option Price for the
Shares purchased pursuant to the exercise of the Option shall be made either
(i) in cash or in cash equivalents; (ii) through the tender to the Company of
Shares (so long as any Shares so tendered that were originally acquired by the
Optionee from the Company have been held by the Optionee for at least six (6)
months prior to such tender), which Shares shall be valued, for purposes of
determining the extent to which the Option Price has been paid thereby, at
their fair market value on the date of exercise; or (iii) by a

3

combination of
the methods described in (i) and (ii). Payment in full of the Option Price
need not accompany the written notice of exercise provided the notice of exercise
directs that the Share certificate or certificates for the Shares for which the
Option is exercised be delivered to a licensed broker acceptable to the Company
as the agent for the Optionee and, at the time such Share certificate or
certificates are delivered, the broker tenders the Company cash (or cash
equivalents acceptable to the Company) equal to the Option Price for the Shares
purchased pursuant to the exercise of the Option plus the amount (if any) of
federal and/or other taxes which the Company may, in its judgment, be required
to withhold with respect to the exercise of the Option. If the person
exercising the Option is not the Optionee, such person shall also deliver with
the notice of exercise appropriate proof of his or her right to exercise the
Option. An attempt to exercise the Option granted hereunder other than as set
forth above shall be invalid and of no force and effect. Promptly after
exercise of the Option as provided for above, the Company shall deliver to the
person exercising the Option a certificate or certificates for the Shares being
purchased.

6. TRANSFERABILITY OPTIONS.

            During the lifetime of an Optionee, only such Optionee (or, in the event
of legal incapacity or incompetence, the Optionee’s guardian or legal
representative) may exercise the Option. No Option shall be assignable or
transferable by the Optionee, other than by will or the laws of descent and
distribution.

7. RIGHTS AS STOCKHOLDER.

            Neither the Optionee nor any executor, administrator, distributee or
legatee of the Optionee’s estate shall be, or have any of the rights or
privileges of, a stockholder of the Company in respect of any Shares
transferable hereunder unless and until such Shares have been fully paid and
certificates representing such Shares have been endorsed, transferred and
delivered, and the name of the Optionee (or of such personal representative,
administrator, distributee or legatee of the Optionee’s estate) has been
entered as the stockholder of record on the books of the Company.

8. EFFECT OF CHANGES IN CAPITALIZATION.

      8.1 Changes in Shares.

            If the number of outstanding Shares is increased or decreased or the
Shares are changed into or exchanged for a different number or kind of Shares
or other securities of the Company on account of any recapitalization,
reclassification, stock split, reverse split, combination of Shares, exchange
of Shares, stock dividend or other distribution payable in capital stock, or
other increase or decrease in such Shares effected without receipt of
consideration by the Company occurring after the date the Option is granted, a
proportionate and appropriate adjustment shall be made by the Company in the
number and kind of Shares subject to the Option, so that the proportionate
interest of the Optionee immediately following such event shall, to the extent
practicable, be the same as immediately prior to such event. Any such
adjustment in the Option shall not change the aggregate Option Price payable
with respect to Shares subject to the unexercised portion of the Option but
shall include a corresponding proportionate adjustment in the Option Price per
Share.

4

      8.2 Reorganization in Which the Company Is the Surviving Entity.

            Subject to Section 8.3, if the Company shall be the surviving entity in
any reorganization, merger or consolidation of the Company with one or more
other entities, the Option shall pertain to and apply to the securities to
which a holder of the number of Shares subject to the Option would have been
entitled immediately following such reorganization, merger or consolidation,
with a corresponding proportionate adjustment of the Option Price per Share so
that the aggregate Option Price thereafter shall be the same as the aggregate
Option Price of the Shares remaining subject to the Option immediately prior to
such reorganization, merger or consolidation.

      8.3 Reorganization in Which the Company Is Not the Surviving
Entity or Sale of Assets or Shares.

            Upon the dissolution or liquidation of the Company, or upon a merger,
consolidation or reorganization of the Company with one or more other entities
in which the Company is not the surviving entity, or upon a sale of
substantially all of the assets of the Company to another entity, or upon any
transaction (including, without limitation, a merger or reorganization in which
the Company is the surviving entity) approved by the Board which results in any
person or entity (or persons or entities acting as a group or otherwise in
concert) owning 80 percent or more of the combined voting power of all classes
of securities of the Company, the Option hereunder shall terminate, except to
the extent provision is made in connection with such transaction for the
continuation and/or the assumption of the Option, or for the substitution for
the Option of new options covering the stock of a successor employer entity, or
a parent or subsidiary thereof, with appropriate adjustments as to the number
and kinds of shares and exercise prices, in which event the Option shall
continue in the manner and under the terms so provided. In the event of any
such termination of the Option, the Optionee shall have the right (subject to
the limitations on exercise set forth in Section 3.5 above), for 30 days
immediately prior to the occurrence of such termination, to exercise the Option
in whole or in part, whether or not the Optionee was otherwise entitled to
exercise such Option at the time such termination occurs. Any exercise during
such thirty (30) day period shall be conditioned upon the consummation of the
event and shall be effective only immediately before the consummation of the
event. The Company shall send written notice of an event that will result in
such a termination to the Optionee not later than the time at which the Company
gives notice thereof to its stockholders.

      8.4 Adjustments.

            Adjustments specified in this Section relating to Shares or securities of
the Company shall be made by the Board of Directors of the Company, whose
determination in that respect shall be final, binding and conclusive. No
fractional Shares or units of other securities shall be issued pursuant to any
such adjustment, and any fractions resulting from any such adjustment shall be
eliminated in each case by rounding downward to the nearest whole share or
unit.

5

9. REQUIREMENTS OF LAW.

            The Company shall not be required to sell or issue any Shares under the
Option if the sale or issuance of such Shares would constitute a violation by
the individual exercising the Option or by the Company of any provision of any
law or regulation of any governmental authority,
including, without limitation, any federal or state securities laws or
regulations. If at any time the Company shall determine, in its discretion,
that the listing, registration or qualification of any Shares subject to the
Option upon any securities exchange or under any state or federal law, or the
consent or approval of any government regulatory body, is necessary or
desirable as a condition of, or in connection with, the issuance or purchase of
Shares hereunder, the Option may not be exercised in whole or in part unless
such listing, registration, qualification, consent or approval shall have been
effected or obtained free of any conditions not acceptable to the Company, and
any delay caused thereby shall in no way affect the date of termination of the
Option. Specifically in connection with the Securities Act, unless a
registration statement under such Act is in effect with respect to the Shares
covered by the Option, the Company shall not be required to sell or issue such
Shares unless the Company has received evidence satisfactory to it that the
holder of the Option may acquire such Shares pursuant to an exemption from
registration under such Act. Any determination in this connection by the
Company shall be final, binding, and conclusive. The Company may, but shall in
no event be obligated to, register any securities covered hereby pursuant to
the Securities Act. The Company shall not be obligated to take any affirmative
action in order to cause the exercise of the Option or the issuance of shares
pursuant thereto to comply with any law or regulation of any governmental
authority. As to any jurisdiction that expressly imposes the requirement that
the Option shall not be exercisable unless and until the Shares covered by the
Option are registered or are subject to an available exemption from
registration, the exercise of the Option (under circumstances in which the laws
of such jurisdiction apply) shall be deemed conditioned upon the effectiveness
of such registration or the availability of such an exemption.

10. INTERPRETATION OF THIS AGREEMENT.

            All decisions and interpretations made by the Board of Directors of the
Company with regard to any question arising under this Agreement shall be
binding and conclusive on the Company and the Optionee and any other person
entitled to exercise the Option as provided for herein.

11. GOVERNING LAW.

            This Agreement is executed pursuant to and shall be governed by the laws
of the State of Maryland (without regard to any rules or principles of
conflicts of law that might look to any jurisdiction outside Maryland).

12. BINDING EFFECT

            Subject to all restrictions provided for in this Agreement and by
applicable law relating to assignment and transfer of this Agreement and the
Option provided for herein, this Agreement shall be binding upon and inure to
the benefit of the parties hereto and their respective heirs, executors,
administrators, successors, and assigns.

6

13. NOTICE.

            Any notice hereunder by the Optionee to the Company shall be in writing
and shall be deemed duly given if mailed or delivered to the Company at its
principal office, addressed to the attention of the Board of Directors, or if
so mailed or delivered to such other address as the Company may hereafter
designate by notice to the Optionee. Any notice hereunder by the Company to
the Optionee shall be in writing and shall be deemed duly given if mailed or
delivered to the Optionee at the address specified below by the Optionee for
such purpose, or if so mailed or delivered to such other address as the
Optionee may hereafter designate by written notice given to the Company.

14. ENTIRE AGREEMENT.

            This Agreement constitutes the entire agreement and supersedes all prior
understandings and agreements, written or oral, of the parties hereto with
respect to the subject matter hereof. Neither this Agreement nor any term
hereof may be amended, waived, discharged or terminated except by a written
instrument signed by the Company and the Optionee; provided, however, that the
Company unilaterally may waive any provision hereof in writing to the extent
that such waiver does not adversely affect the interests of the Optionee
hereunder, but no such waiver shall operate as or be construed to be a
subsequent waiver of the same provision or a waiver of any other provision
hereof.

REMAINDER OF PAGE LEFT BLANK

SIGNATURES FOLLOW

7

            IN WITNESS WHEREOF, the parties hereto have duly executed this Option
Agreement, or caused this Option Agreement to be duly executed on their behalf,
as of the day and year first above written.

	 	 	 
	ATTEST:		
GUILFORD PHARMACEUTICALS INC.
	 
	
	
	
	

	/s/ Asher Rubin		By: /s/ Andrew Jordan
	
		

	Asher Rubin		Title: Sr. VP, General Counsel & Secretary
	 
	
	
	
	

			OPTIONEE:
	 
			 /s/ Susan M. Smith
			

	
	
	
	

			(signature)

ADDRESS FOR NOTICE TO OPTIONEE:
	 
			6        Blenmount Court
			

	
	
	
	

			Number                                   
             Street
	 
			Phoenix,                            MD      
                              21131
			

	
	
	
	

			City                                   
 State                                    Zip Code

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