Document:

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                                                                   EXHIBIT 10.13

                               [TOMAX LETTERHEAD]

July 25, 2000

PERSONAL DELIVERY

Brad Lee Stewart
817 North Park Shadows Circle
Bountiful, Utah 84010

Dear Mr. Stewart:

This letter is your formal offer to join our team in the capacity of Sr. Vice
President and Chief Financial Officer, effective August 14, 2000, or earlier if
available.

OVERALL RESPONSIBILITIES

As Chief Financial Officer (CFO) you will be responsible for complete fiscal
management of Tomax, including all reporting, oversight, process and staff
functions within the financial area. Primarily, you will establish the plan and
guide the company through a successful IPO process.

Equally, you will be joining the Tomax Click & Mortar Leadership Team, a group
of area leaders chosen to purpose Tomax towards its goals and objectives,
responsible for all planning, direction, and course adjustments along the way.
Your contribution is expected to include input and leadership on budgeting,
goal setting, forecasting, pricing, and management direction.

REPORTING RELATIONSHIPS

You will report to myself as Chief Executive Officer. Additionally, you will
have reporting obligations to the BOD, the Leadership Team, and the Investment
Community as outlined below.

MISSION:

     To provide leadership and vision in the development and implementation of
     financial systems, controls, and operational management systems that help
     establish Tomax as a world class leader in productivity, profitability,
     and sustainable growth. These initiatives will be underwritten by a
     forceful commitment to shareholder value.

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OBJECTIVES:

        To efficiently prepare and guide Tomax through the IPO process,
        including the appropriate management of underwriting, accounting and
        legal resources.

        To attain on valuation objectives to be determined.

        To mentor and development the Tomax team in the finance/operations area.

        Create and maintain a team environment that is productive, efficient,
        and focused on client requirements.

        Ensure the delivery of consistent, accurate, and timely reporting on
        management, accounting, and regulatory requirements to be determined.

TASKS

These objectives are broad and comprehensive in nature. To give specific focus
and direction to your initial efforts, the following tactical initiatives are
offered as priority assignments.

        Establish IPO plan including final selection of the team (underwriters,
        legal, and accounting), valuation objectives, document preparation,
        support plan, and other tactical requirements.

        Review and finalize the business plan, including compensation
        structure, options, incentive programs, and operational budgets.

        Review and finalize forecasting systems and reporting requirements.
        This would include appropriate supporting systems for the BOD.

COMPENSATION PACKAGE

Following is an overview of your compensation package:

        SALARY -- $175,000 per annum, paid bimonthly.

        BONUS AND INCENTIVE PLAN -- commensurate with that offered to members
        of the Leadership Team. Presently this includes a 10% cash bonus based
        on the attainment of objectives, paid quarterly and a stock option
        equal to 37.5% of Salary (based on options at current valuation and
        vesting over 3 years, vesting according to a scheduled determined for
        all members of the Leadership Team, presently three years on a monthly
        basis).

        SIGNING BONUS -- $20,000 and stock options for 100,000 shares of Tomax
        Common stock at (current valuation price), vesting over 3 years, vesting
        at 25% on grant date and 25% on each annual anniversary thereafter for
        three years.

        IPO BONUS -- $30,000 (to be paid on day of closing the IPO of Tomax)
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          The signing and IPO bonus are independent of any other incentives.

          EMPLOYMENT CONTRACT - to be determined following agreement. To include
          1 year severance in the event of termination without cause, (as
          commonly defined) by Tomax or with good reason (as commonly defined)
          by Stewart. Also to include health insurance for Stewart and family,
          401-K plan, life insurance, disability insurance, and other benefits
          as provided to members of the executive team at Tomax.

We also offer a comprehensive employee benefit package. Details are summarized
below:

     -  Company sponsored health and dental insurance. The company pays 50% of
        the monthly premium with the employee paying the remaining 50%. Health
        insurance is effective on the first on the month following your first
        30 days of employment.

     -  Company paid term life insurance equal to one times your gross yearly
        wage up to $50,000.

     -  401K plan where the company contributes $0.50 on the dollar up to the
        first 6% of your contribution with a five-year, 20% vesting schedule.
        Requires six months of full-time employment to meet the eligibility
        requirements.

     -  Employee stock options plan. Requires six-months full-time service with
        the company to meet eligibility requirements.

     -  Company provided long-term disability insurance.

     -  Company sponsored short-term disability insurance. Premiums are paid by
        the employee.

     -  18 days of paid time off (PTO) your first years employment. Beginning
        with your sixth year of employment the number of days of PTO increases
        to 24 per year. In addition we have eight standard holidays each year
        which are paid days of leave.

We are looking forward to you joining our team. With your help, we are going to
build Tomax into the most respected name in the industry. You may indicate your
acceptance by signing both copies and returning one copy to our office.

Yours sincerely,

TOMAX TECHNOLOGIES, INC.

/s/ ERIC OLAFSON
-------------------------
Eric Olafson
CEO

        7/25/00
-------------------------
Date

/s/ BRAD LEE STEWART
-------------------------
Brad Lee Stewart

        7/25/00
-------------------------
Date<PAGE>   1

                                                                     EXHIBIT 4.3

                               PURCHASE AGREEMENT

                THIS PURCHASE AGREEMENT is made as of the 23rd day of August,
2000, by and between Caliper Technologies Corp. (the "Company"), a corporation
organized under the laws of the State of Delaware, with its principal offices at
605 Fairchild Drive, Mountain View, California 94043-2234, and the purchaser
whose name and address is set forth on the signature page hereof (the
"Purchaser").

                IN CONSIDERATION of the mutual covenants contained in this
Agreement, the Company and the Purchaser agree as follows:

                1. SALE AND PURCHASE OF THE SHARES. The Company has authorized
the sale of up to 2,500,000 shares (the "Shares") of common stock, par value
$0.001 per share (the "Common Stock"), of the Company on the terms and subject
to the conditions set forth in this Agreement. At the Closing (as defined in
Section 3), the Company will sell to the Purchaser, and the Purchaser will buy
from the Company, upon the terms and conditions contained in this Agreement, the
number of Shares specified below such Purchaser's name on the signature page
attached hereto at the price set forth thereto.

                2. OTHER PURCHASERS. The Company intends to enter into this same
form of purchase agreement with certain other investors (the "Other Purchasers")
and expects to complete sales of the Shares to them. The Purchaser's obligations
hereunder are expressly not conditioned on the purchase by any or all of the
Other Purchasers of the Shares that they have agreed to purchase from the
Company.

                3. CLOSING; DELIVERY; CONDITIONS.

                3.1 Closing. The purchase and sale of the Shares (the "Closing")
shall occur as soon as practicable after the execution of this Agreement by the
Company, and the Purchasers at the time and location (the "Closing Date") agreed
upon by the Company and the Placement Agent. The Placement Agent will promptly
notify the Purchasers of the date, place and time of the Closing by facsimile
transmission or otherwise.

                3.2 Delivery of the Shares. At the Closing, the Company will
deliver to each Purchaser certificates, registered in the name of such
Purchaser, representing the number of Company Shares to be purchased by such
Purchaser as set forth opposite such Purchaser's name on the signature page
hereto. Such payment of the purchase price therefor shall be made against
delivery of the certificate by wire transfers of immediately available funds in
the respective amounts set forth on the signature page hereto to the respective
accounts as designated in writing by the Company, as the case may be. The
name(s) in which the stock certificate are to be registered are set forth in the
Stock Certificates Questionnaire attached hereto as part of Appendix I.

                                       1.
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                3.3 Closing Conditions.

                        (a) The Company's respective obligations to complete the
purchase and sale of the Shares and deliver the stock certificates representing
the Shares to the Purchasers at the Closing shall be subject to the following
conditions, any one or more of which may be waived by the Company:

                        (1) receipt by the Company of same-day funds in the full
        amount of the purchase price for the Shares being purchased hereunder;
        and

                        (2) the accuracy of the representations and warranties
        made by the Purchasers and the fulfillment of those obligations of the
        Purchasers to be fulfilled prior to the Closing.

                3.4 The Purchaser's obligation to accept delivery of such stock
certificate(s) and to pay for the Shares evidenced thereby shall be subject to
the accuracy in all material respects of the representations and warranties made
by the Company herein and the fulfillment in all material respects of those
obligations of the Company to be fulfilled prior to Closing.

                4. CERTAIN DEFINITIONS. Unless the context otherwise requires,
the terms defined in this Section 4 shall have the meaning herein specified for
purposes of this Agreement.

                "Agreement" means this agreement, including the exhibits and
appendices thereto.

                "Agreements" means this Agreement and the agreements executed by
the Other Purchasers, collectively.

                "Commission" means the Securities and Exchange Commission.

                "Exchange Act" means the Securities and Exchange Act of 1934, as
amended from time to time.

                "Material Adverse Change" means a material adverse change in the
condition (financial or otherwise), properties, business, or results of
operations of the Company.

                "Material Adverse Effect" means a material adverse effect on the
condition (financial or otherwise), properties, business, or results of
operations of the Company.

                "Placement Agent" means CIBC World Markets Corp., Chase
Securities Inc., FleetBoston Roberston Stephens Inc., and Gruntal & Co. LLC

                "Purchasers" means the Purchaser and the Other Purchasers.

                "Private Placement Memorandum" means the Confidential Private
Placement Memorandum dated August 14, 2000, including all exhibits thereto.

                                       2.
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                "Registration Statement" means the registration statement on
Form S-1, as may be amended, filed with the Commission covering the re-sale of
the Shares.

                "Securities Act" means the Securities Act of 1933, as amended
from time to time.

                5. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY. The
Company hereby represents and warrants to, and covenants with, the Purchaser as
follows:

                5.1 Organization and Qualification. The Company is a corporation
duly organized, validly existing and in good standing under the laws of the
State of Delaware. The Company is duly qualified to do business and is in good
standing as a foreign corporation in each jurisdiction in which the nature of
the business conducted by it or location of the assets or properties, owned,
leased or licensed by it requires such qualification, except where failure to so
qualify or to be in good standing would not have a Material Adverse Effect on
the Company.

                5.2 Authorized Capital Stock. The Company had the authorized and
outstanding capital stock set forth under the heading "Capitalization" in the
Private Placement Memorandum, as of the date set forth therein. All of the
issued and outstanding shares of the Company's Common Stock have been duly
authorized and validly issued, are fully paid and nonassessable, have been
issued in compliance with all federal and state securities laws, were not issued
in violation of or subject to any preemptive rights or other rights to subscribe
for or purchase securities, and conform in all material respects to the
description thereof contained in the Private Placement Memorandum. Except as
disclosed in or contemplated by the Private Placement Memorandum, the Company
does not have outstanding any options to purchase, or any preemptive rights or
other rights to subscribe for or to purchase, any securities or obligations
convertible into, or any contracts or commitments to issue or sell, shares of
its capital stock.

                5.3 Shares. The Shares have been duly authorized and, when
issued, delivered and paid for in the manner set forth in this Agreement, will
be duly authorized, validly issued, fully paid and nonassessable, and will
conform in all material respects to the description thereof set forth in the
Private Placement Memorandum. No preemptive rights or other rights to subscribe
for or purchase exist with respect to the issuance and sale of the Shares by the
Company pursuant to this Agreement. No stockholder of the Company has any right
(which has not been waived or has not expired by reason of lapse of time
following notification of the Company's intent to file the Registration
Statement) to require the Company to register the sale of any shares owned by
such stockholder under the Securities Act in the Registration Statement. No
further approval or authority of the stockholders or the Board of Directors of
the Company will be required for the issuance and sale of the Shares to be sold
by the Company as contemplated herein.

                5.4 Corporate Acts and Proceedings. The Company has full legal
right, corporate power and authority to enter into the Agreements and perform
the transactions contemplated hereby. The Agreements have been duly and validly
authorized, executed and delivered by the Company. The making and performance of
the Agreements by the Company and the consummation of the transactions herein
contemplated will not violate any provision of the organizational documents of
the Company and will not result in the creation of any lien, charge, security
interest or encumbrance

                                       3.
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upon any assets of the Company pursuant to the terms or provisions of, or will
not conflict with, result in the breach or violation of, or constitute, either
by itself or upon notice or the passage of time or both, a default under any
agreement, mortgage, deed of trust, lease, franchise, license, indenture, permit
or other instrument to which the Company is a party or by which the Company or
its properties may be bound or affected and in each case which would have a
Material Adverse Effect or, to the Company's knowledge, any statute or any
authorization, judgment, decree, order, rule or regulation of any court or any
regulatory body, administrative agency or other governmental body applicable to
the Company or its properties. No consent, approval, authorization or other
order of any court, regulatory body, administrative agency or other governmental
body is required for the execution and delivery of this Agreement or the
consummation of the transactions contemplated by this Agreement, except for
compliance with the Blue Sky laws and federal securities laws applicable to the
offering of the Shares. Upon their execution and delivery, and assuming the
valid execution thereof by the respective Purchasers, the Agreements will
constitute valid and binding obligations of the Company, enforceable in
accordance with their respective terms, except as enforceability may be limited
by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws
affecting the enforcement of creditors' and contracting parties' rights
generally and except as enforceability may be subject to general principles of
equity (regardless of whether such enforceability is considered in a proceeding
in equity or at law) and except as the indemnification agreements of the Company
in Section 9 hereof may be legally unenforceable.

                5.5 No Actions. Except as disclosed in the Private Placement
Memorandum, there are no legal or governmental actions, suits or proceedings
pending or, to the Company's knowledge, overtly threatened to which the Company
or may be a party or of which property owned or leased by the Company or may be
the subject, or related to environmental or discrimination matters, which
actions, suits or proceedings, individually or in the aggregate, might prevent
or might reasonably be expected to materially and adversely affect the
transactions contemplated by this Agreement or result in a Material Adverse
Change; and no labor disturbance by the employees of the Company exists, to the
Company's knowledge, or is imminent which might reasonably be expected to have a
Material Adverse Effect. Except as disclosed in the Private Placement
Memorandum, the Company is not a party to or subject to the provisions of any
material injunction, judgment, decree or order of any court, regulatory body
administrative agency or other governmental body.

                5.6 Proprietary Rights. Except as disclosed in the Private
Placement Memorandum, (i) to the Company's knowledge, the Company has filed for
or holds licenses or options for the inventions, patent applications, patents,
trademarks (both registered and unregistered), trade names, copyrights and trade
secrets necessary for the conduct of the Company's business as currently
conducted and as the Private Placement Memorandum indicates the Company
contemplates conducting (collectively, the "Intellectual Property") except where
the failure to have such rights would not reasonably be expected to have a
Material Adverse Effect; and (ii) to the Company's knowledge (for each of the
following subsections (a) through (e)): (a) there are no third parties who have
any ownership rights to any Intellectual Property that is owned by, or has been
licensed to the Company for the product indications described in the Private
Placement Memorandum in the case of any business the Company has or intends to
conduct during the year ending December 31, 2000 that would preclude the Company
from conducting its business as currently conducted and as the

                                       4.
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Private Placement Memorandum indicates the Company contemplates conducting; (b)
there are currently no sales of any products that would constitute an
infringement by third parties of any Intellectual Property owned, licensed or
optioned by the Company; (c) there is no pending or threatened action, suit,
proceeding or claim by others challenging the rights of the Company in or to any
Intellectual Property owned, licensed or optioned by the Company, other than
non-material claims; (d) there is no pending or threatened action, suit,
proceeding or claim by others challenging the validity or scope of any
Intellectual Property owned, licensed or optioned by the Company, other than
non-material claims; and (e) there is no pending or threatened action, suit,
proceeding or claim by others that the Company infringes or otherwise violate
any patent, trademark, copyright, trade secret or other proprietary right of
others, other than non-material claims.

                5.7 No Material Adverse Change. Since June 30, 2000, and except
as disclosed in the Private Placement Memorandum, (i) the Company has not
incurred any material liabilities or obligations, indirect, or contingent, or
entered into any material verbal or written agreement or other transaction which
is not in the ordinary course of business or which could reasonably be expected
to have a Material Adverse Effect; (ii) the Company has not sustained any
material loss or interference with its businesses or properties from fire,
flood, windstorm, accident or other calamity not covered by insurance; (iii) the
Company has not paid or declared any dividends or other distributions with
respect to its capital stock and the Company is not in default in the payment of
principal or interest on any outstanding debt obligations; (iv) there has not
been any change in the capital stock of the Company other than the sale of the
Shares hereunder and shares or options issued pursuant to employee equity
incentive plans or purchase plans, or indebtedness material to the Company
(other than in the ordinary course of business); and (v) there has not been a
Material Adverse Change.

                5.8 Financial Statement. Ernst & Young LLP (a) have expressed
their opinion with respect to the consolidated financial statements included in
the Company's Annual Report on Form 10-K for the fiscal year ended December 31,
1999, (b) have not given the Company any indication that they will not include
such opinion in the Registration Statement and the Prospectus, and (c) have
confirmed to the Company that they are independent accountants as required by
the Securities Act and the rules and regulations promulgated thereunder.

                5.9 No Defaults. Except as to defaults, violations and breaches
which individually or in the aggregate would not be material to the Company, the
Company is not in violation or default of any provision of its certificate of
incorporation or bylaws, or other organizational documents, or in breach of, or
default with respect to, any provision of any material agreement filed as an
exhibit to the Company's filings with the Commission, judgment, decree, order,
mortgage, deed of trust, lease, franchise, license, indenture, or permit to
which it is a party or by which it or any of its properties are bound; and there
does not exist any state of fact which, with notice or lapse of time or both,
would constitute an event of breach or default on the part of the Company as
defined in such documents, except such breaches or defaults which individually
or in the aggregate would not reasonably be expected to have a Material Adverse
Effect on the Company.

                5.10 Compliance. The Company believes that it is conducting its
business in compliance with all applicable laws, rules and regulations of the
jurisdictions in which it is

                                       5.
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conducting business, including, without limitation, all applicable local, state
and federal environmental laws and regulations; except where failure to be so in
compliance would not have a Material Adverse Effect.

                5.11 Disclosure. No facts have come to the Company's attention
which cause the Company to believe that the statements in the Private Placement
Memorandum, including the Exhibits thereto as of their respective dates, when
taken together contain an untrue or misleading statement of material fact, or
omit a material fact necessary to make the statements therein not misleading.

                5.12 Additional Information. The Company represents and warrants
that the information contained in the following documents, which the Placement
Agent has furnished to the Purchaser, or will furnish prior to the Closing, is
true and correct in all material respects as of the respective dates that they
were filed with the Commission, or their final dates, if not filed with the
Commission:

                        (a)     the Company's Annual Report on Form 10-K for the
                                fiscal year ended December 31, 1999;

                        (b)     the Company's Quarterly Report on Form 10-Q for
                                the quarterly period ended March 31, 2000;

                        (c)     the Company's Proxy Statement for the 2000
                                Annual Meeting of Stockholders;

                        (d)     the Company's Quarterly Report on Form 10-Q for
                                the quarterly period ended June 30, 2000;

                        (e)     the Registration Statement;

                        (f)     the Private Placement Memorandum, including all
                                addenda and exhibits thereto (other than the
                                Appendices); and

                        (g)     all other documents, if any, filed by the
                                Company with the Commission since August 11,
                                2000 pursuant to the reporting requirements of
                                the Exchange Act.

                5.13 Legal Opinions. Prior to the Closing, Cooley Godward LLP,
counsel to the Company, will deliver its legal opinion to the Placement Agent
solely for the benefit of the Placement Agent, substantially in such form as
such counsel rendering the opinion and the Placement Agent may agree upon.

                                       6.
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                6. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PURCHASER.

                6.1 Investment Intent and Expense. The Purchaser represents and
warrants to, and covenants with, the Company that: (i) the Purchaser is
knowledgeable, sophisticated and experienced in making, and is qualified to
make, decisions with respect to investments in shares representing an investment
decision like that involved in the purchase of the Shares, including investments
in securities issued by the Company, and has requested, received, reviewed and
considered all information it deems relevant in making an informed decision to
purchase the Shares; (ii) the Purchaser is acquiring the number of Shares set
forth in Section 2 above in the ordinary course of its business and for its own
account for investment (as defined for purposes of the Hart-Scott-Rodino
Antitrust Improvement Act of 1976 and the regulations thereunder) only and with
no present intention of distributing any of such Shares or any arrangement or
understanding with any other persons regarding the distribution of such Shares
within the meaning of Section 2(11) of the Securities Act of 1933; (iii) the
Purchaser will not, directly or indirectly, offer, sell, pledge, transfer or
otherwise dispose of (or solicit any offers to buy, purchase or otherwise
acquire or take a pledge of) any of the Shares except in compliance with the Act
and the Rules and Regulations; (iv) the Purchaser has completed or caused to be
completed the Registration Statement Questionnaire and the Stock Certificate
Questionnaire, both attached hereto as Appendix I, for use in preparation of the
Registration Statement, and the answers thereto are true and correct as of the
date hereof and will be true and correct as of the effective date of the
Registration Statement; (v) the Purchaser has, in connection with its decision
to purchase the number of Shares set forth in Section 2 above, relied solely
upon the Private Placement Memorandum and the documents included therein and the
representations and warranties of the Company contained herein; and (vi) the
Purchaser is an "qualified institutional buyer" within the meaning of Rule 144A
promulgated under the Securities Act.

                6.2 Restrictions on Transfer. The Purchaser hereby covenants
with the Company not to make any sale of the Shares without satisfying the
prospectus delivery requirement under the Securities Act, and the Purchaser
acknowledges and agrees that such Shares are not transferable on the books of
the Company unless the certificate submitted to the transfer agent evidencing
the Shares is accompanied by a separate Purchaser's Certificate: (i) in the form
of Appendix II hereto, (ii) executed by an officer of, or other authorized
person designated by, the Purchaser, and (iii) to the effect that (A) the Shares
have been sold in accordance with the Registration Statement, the Securities Act
and the Rules and Regulations and any applicable state securities or blue sky
laws and (B) the requirement of delivering a current prospectus has been
satisfied. The Purchaser acknowledges that there may occasionally be times when
the Company, in good faith and with consideration by the Board of Directors or a
committee thereof, determines the use of the prospectus forming a part of the
Registration Statement should be suspended until such time as an amendment or
supplement to the Registration Statement or the Prospectus has been filed by the
Company and any such amendment to the Registration Statement is declared
effective by the Commission, or until such time as the Company has filed an
appropriate report with the Commission pursuant to the Exchange Act. The
Purchaser hereby covenants that it will not sell any Shares pursuant to said
prospectus during the period commencing at the time at which the Company gives
the Purchaser written notice of the suspension of the use of said prospectus and
ending at the time the Company gives the Purchaser written notice that the
Purchaser may thereafter effect sales pursuant to said

                                       7.
<PAGE>   8

prospectus. The Purchaser further covenants to notify the Company promptly of
the sale of all of its Shares. Notwithstanding the above, the Purchaser shall be
entitled to make any transfer or sale of the Shares pursuant to an available
exemption from the prospectus delivery requirements under the federal securities
laws if the Purchaser shall provide to the Company a detailed statement of the
circumstances surrounding the proposed transfer and an opinion of counsel
reasonably satisfactory to the Company stating that registration is not required
and that the transfer is in accordance with all applicable federal and state
securities laws; provided, however, that (i) no such notice or opinion of
counsel shall be necessary for a transfer made in compliance with Rule 144 and
(ii) no such opinion of counsel shall be necessary for a transfer by the
undersigned to an entity controlling, controlled by or under common control with
the Purchaser.

                6.3 Authorization. The Purchaser further represents and warrants
to, and covenants with, the Company that (i) the Purchaser has full right,
power, authority and capacity to enter into this Agreement and to consummate the
transactions contemplated hereby and has taken all necessary action to authorize
the execution, delivery and performance of this Agreement, and (ii) upon the
execution and delivery of this Agreement, this Agreement shall constitute a
valid and binding obligation of the Purchaser enforceable in accordance with its
terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting creditors' and
contracting parties' rights generally and except as enforceability may be
subject to general principles of equity (regardless of whether such
enforceability is considered in a proceeding in equity or at law) and except as
the indemnification agreements of the Purchaser in Section 9 hereof may be
legally unenforceable.

                6.4 Restriction on Sales, Short Sales and Hedging Transactions.
Purchaser represents and agrees that during the period of five business days
immediately prior to the execution of this Agreement by Purchaser, Purchaser did
not, and from such date through the effectiveness of the Registration Statement
(as defined below), Purchaser will not, directly or indirectly, execute or
effect or cause to be executed or effected any short sale, option or equity swap
transactions in or with respect to the Common Stock or any other derivative
security transaction the purpose or effect of which is to hedge or transfer to a
third party all or any part of the risk of loss associated with the ownership of
the Shares by the Purchaser; provided however, that the Purchaser shall be
allowed to effectuate such above described transactions after the Closing Date,
but only up to the aggregate number of Shares purchased by such Purchaser
hereunder, and then only in compliance with all applicable state and federal
securities laws and the rules and regulations thereunder.

                6.5 No Legal, Tax or Investment Advice. Purchaser understands
that nothing in the Private Placement Memorandum, the Agreement or any other
materials presented to Purchaser in connection with the purchase and sale of the
Shares constitutes legal, tax or investment advice. Purchaser has consulted such
legal, tax and investment advisors as it, in its sole discretion, has deemed
necessary or appropriate in connection with its purchase of the Shares.

                6.6 Further Agreements of Purchaser

                (a) The Purchaser understands that the Shares are being offered
and sold to it in reliance upon specific exemptions from the registration
requirements of the Securities Act, the Rules

                                       8.
<PAGE>   9

and Regulations and state securities laws and that the Company is relying upon
the truth and accuracy of, and the Purchaser's compliance with, the
representations, warranties, agreements, acknowledgments and understandings of
the Purchaser set forth herein in order to determine the availability of such
exemptions and the eligibility of the Purchaser to acquire the Shares.

                (b) The Purchaser understands that its investment in the Shares
involves a significant degree of risk and that the market price of the Common
Stock has been volatile and that no representation is being made as to the
future value of the Common Stock. The Purchaser has the knowledge and experience
in financial and business matters as to be capable of evaluating the merits and
risks of an investment in the Shares and has the ability to bear the economic
risks of an investment in the Shares.

                (c) The Purchaser understands that no United States federal or
state agency or any other government or governmental agency has passed upon or
made any recommendation or endorsement of the Shares.

                (d) The Purchaser understands that, until such time as the
Registration Statement has been declared effective or the Shares may be sold
pursuant to Rule 144 under the Securities Act without any restriction as to the
number of securities as of a particular date that can then be immediately sold,
the Shares may bear a restrictive legend in substantially the following form
(and a stop-transfer order may be placed against transfer of the certificates
for the Shares):

                "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
                REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THE
                SECURITIES MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED IN THE
                ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE
                SECURITIES UNDER SAID ACT, OR AN OPINION OF COUNSEL, IN FORM,
                SUBSTANCE AND SCOPE REASONABLY ACCEPTABLE TO THE COMPANY, THAT
                REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR UNLESS SOLD
                PURSUANT TO RULE 144 UNDER SAID ACT."

                (e) The Purchaser's principal executive offices are in the
jurisdiction set forth immediately below the Purchaser's name on the signature
pages hereto.

                7. SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS.
Notwithstanding any investigation made by any party to this Agreement or by the
Placement Agent, all covenants, agreements, representations and warranties made
by the Company and the Purchaser herein and in the certificates for the Shares
delivered pursuant hereto shall survive the execution of this Agreement, the
delivery to the Purchaser of the Shares being purchased and the payment
therefor.

                8. COVENANTS.

                8.1 Registration Procedures and Expenses. The Company shall:

                                       9.
<PAGE>   10

                        (a)     as soon as practicable, but in any event no
                                later than September 15, 2000, prepare and file
                                with the Commission the Registration Statement
                                on Form S-1 relating to the sale of the Shares
                                by the Purchaser from time to time through the
                                automated quotation system of the Nasdaq
                                National Market or the facilities of any
                                national securities exchange on which the
                                Company's Common Stock is then traded or in
                                privately-negotiated transactions;

                        (b)     use its reasonable efforts subject to receipt of
                                necessary information from the Purchasers, to
                                cause the Commission to notify the Company of
                                the Commission's willingness to declare the
                                Registration Statement effective and shall
                                therewith notify the Purchasers of the
                                declaration of effectiveness and shall also
                                promptly notify the Purchasers of any stop
                                orders issued by the Commission;

                        (c)     prepare and file with the Commission such
                                amendments and supplements to the Registration
                                Statement and the prospectus used in connection
                                therewith as may be necessary to keep the
                                Registration Statement effective until the
                                earlier of (i) twenty-four (24) months after the
                                effective date of the Registration Statement or
                                (ii) the date on which all of the Shares have
                                been sold by the Purchasers or on which the
                                Shares may be sold pursuant to Rule 144 under
                                the Securities Act without any restriction as to
                                the number of securities as of a particular date
                                that can then be immediately sold;

                        (d)     furnish to the Purchaser with respect to the
                                Shares registered under the Registration
                                Statement (and to each underwriter, if any, of
                                such Shares) such reasonable number of copies of
                                prospectuses in order to facilitate the public
                                sale or other disposition of all or any of the
                                Shares by the Purchaser;

                        (e)     file documents required of the Company for
                                normal blue sky clearance in states specified in
                                writing by the Purchaser; provided, however,
                                that the Company shall not be required to
                                qualify to do business or consent to service of
                                process in any jurisdiction in which it is not
                                now so qualified or has not so consented;

                        (f)     bear all expenses in connection with the
                                procedures in paragraphs (a) through (e) of this
                                Section 8.1 and the registration of the Shares
                                pursuant to the Registration Statement, other
                                than fees and expenses, if any, of counsel or
                                other advisers to the Purchaser or the Other
                                Purchasers or underwriting discounts, brokerage
                                fees and commissions incurred by the Purchaser
                                or the Other Purchasers, if any; and

                                      10.
<PAGE>   11

                        (g)     With a view to making available to Purchaser the
                                benefits of Rule 144 (or its successor rule) and
                                any other rule or regulation of the Commission
                                that may at any time permit Purchaser to sell
                                the Shares to the public without registration,
                                the Company covenants and agrees to: (i) make
                                and keep public information available, as those
                                terms are understood and defined in Rule 144,
                                until the earlier of (A) such date as all of
                                Purchaser's Shares may be resold within a given
                                three-month period pursuant to Rule 144 or any
                                other rule or similar effect or (B) such date as
                                all of Purchaser's Shares shall have been
                                resold; and (ii) file with the Commission in a
                                timely manner all reports and other documents
                                required of the Company under the Securities Act
                                and under the Exchange Act.

                8.2 Transfer of Shares After Registration. The Purchaser agrees
that it will not effect any disposition of the Shares or its right to purchase
the Shares that would constitute a sale within the meaning of the Securities
Act, except as contemplated in the Registration Statement referred to in Section
8.1 or pursuant to a valid exemption from the prospectus delivery requirements
in accordance with Section 8.1, and that it will promptly notify the Company of
any changes in the information set forth in the Registration Statement regarding
the Purchaser or its Plan of Distribution.

                8.3 Termination of Conditions and Obligations. The restrictions
imposed by Section 6 or this Section 8 upon the transferability of the Shares
shall cease and terminate as to any particular number of the Shares upon the
passage of twenty-four (24) months from the Closing Date or at such time as an
opinion of counsel satisfactory in form and substance to the Company shall have
been rendered to the effect that such conditions are not necessary in order to
comply with the Securities Act.

                8.4 Information Available. So long as the Registration Statement
is effective covering the resale of Shares owned by the Purchaser, the Company
will furnish to the Purchaser:

                        (a)     upon request, as soon as practicable after
                                available (but in the case of the Company's
                                Annual Report to Stockholders, within 120 days
                                after the end of each fiscal year of the
                                Company), one copy of (i) its Annual Report to
                                Stockholders (which Annual Report shall contain
                                financial statements audited in accordance with
                                generally accepted accounting principles by a
                                national firm of certified public accountants),
                                (ii) if not included in substance in the Annual
                                Report to Stockholders, its Annual Report on
                                Form 10-K, (iii) if not included in substance in
                                its Quarterly Reports to Shareholders, its
                                quarterly reports on Form 10-Q, and (iv) a full
                                copy of the particular Registration Statement
                                covering the Shares (the foregoing, in each
                                case, excluding exhibits);

                                      11.
<PAGE>   12

                        (b)     upon the reasonable request of the Purchaser, a
                                reasonable number of copies of the prospectuses
                                to supply to any other party requiring such
                                prospectuses;

and the Company, upon the reasonable request of the Purchaser, will meet with
the Purchaser or a representative thereof at the Company's headquarters to
discuss information relevant for disclosure in the Registration Statement
covering the Shares subject to appropriate confidentiality limitations.

                8.5 Subsequent Registration Rights. Until such time as the
Registration Statement is declared effective by the Commission, the Company
shall not grant any person or entity registration rights which are superior to,
or inconsistent with, the registration rights of the Purchasers hereunder.

                9. INDEMNIFICATION. For the purpose of this Section 9 only:

                        (a)     the term "Purchaser" shall include the Purchaser
                                and any affiliate, officer, employee, director,
                                limited partner, general partner or member of
                                such Purchaser; and the term "Registration
                                Statement" shall include any final prospectus,
                                exhibit, supplement or amendment included in or
                                relating to the Registration Statement referred
                                to in Section 8.1.

                        (b)     The Company agrees to indemnify and hold
                                harmless each of the Purchasers and each person,
                                if any, who controls any Purchaser within the
                                meaning of the Securities Act, against any and
                                all losses, claims, damages, liabilities or
                                expenses, joint or several, to which such
                                Purchasers or such controlling person may become
                                subject, under the Securities Act, the Exchange
                                Act, or any other federal or state statutory law
                                or regulation, or at common law or otherwise
                                (including in settlement of any litigation, if
                                such settlement is effected with the written
                                consent of the Company), insofar as such losses,
                                claims, damages, liabilities or expenses (or
                                actions in respect thereof as contemplated
                                below) arise out of or are based upon any untrue
                                statement or alleged untrue statement of any
                                material fact contained in the Registration
                                Statement, including the prospectus, financial
                                statements and schedules, and all other
                                documents filed as a part thereof, as amended at
                                the time of effectiveness of the Registration
                                Statement (the "Prospectus"), or any amendment
                                or supplement thereto, or arise out of or are
                                based upon the omission or alleged omission to
                                state in any of them a material fact required to
                                be stated therein or necessary to make the
                                statements in any of them, in light of the
                                circumstances under which they were made, not
                                misleading, or arise out of or are based in
                                whole or in part on any inaccuracy in the
                                representations and warranties of the Company
                                contained in this Agreement, or any failure of
                                the Company to perform in all material

                                      12.
<PAGE>   13

                                respects its obligations hereunder or under law,
                                and will reimburse each Purchaser and each such
                                controlling person for any legal and other
                                expenses as such expenses are reasonably
                                incurred by such Purchaser or such controlling
                                person in connection with investigating,
                                defending, settling, compromising or paying any
                                such loss, claim, damage, liability, expense or
                                action; provided, however, that the Company will
                                not be liable in any such case to the extent
                                that any such loss, claim, damage, liability or
                                expense arises out of or is based upon (i) an
                                untrue statement or alleged untrue statement or
                                omission or alleged omission made in the
                                Registration Statement, the Prospectus or any
                                amendment or supplement thereto in reliance upon
                                and in conformity with written information
                                furnished to the Company by or on behalf of the
                                Purchaser expressly for use therein, or (ii) the
                                failure of such Purchaser to comply with the
                                covenants and agreements contained in Sections
                                6.2 or 8.2 hereof respecting sale of the Shares,
                                or (iii) the inaccuracy of any representations
                                made by such Purchaser herein or (iv) any
                                statement or omission in any Prospectus that is
                                corrected in any subsequent Prospectus that was
                                delivered to the Purchaser prior to the
                                pertinent sale or sales by the Purchaser.

                        (c)     Each Purchaser will severally indemnify and hold
                                harmless the Company, each of its directors,
                                each of its officers who signed the Registration
                                Statement and each person, if any, who controls
                                the Company within the meaning of the Securities
                                Act, against any losses, claims, damages,
                                liabilities or expenses to which the Company,
                                each of its directors, each of its officers who
                                signed the Registration Statement or controlling
                                person may become subject, under the Securities
                                Act, the Exchange Act, or any other federal or
                                state statutory law or regulation, or at common
                                law or otherwise (including in settlement of any
                                litigation, if such settlement is effected with
                                the written consent of such Purchaser) insofar
                                as such losses, claims, damages, liabilities or
                                expenses (or actions in respect thereof as
                                contemplated below) arise out of or are based
                                upon any untrue or alleged untrue statement of
                                any material fact contained in the Registration
                                Statement, the Prospectus, or any amendment or
                                supplement thereto, or arise out of or are based
                                upon the omission or alleged omission to state
                                therein a material fact required to be stated
                                therein or necessary to make the statements
                                therein not misleading, in each case to the
                                extent, but only to the extent, that such untrue
                                statement or alleged untrue statement or
                                omission or alleged omission was made in the
                                Registration Statement, the Prospectus, or any
                                amendment or supplement thereto, in reliance
                                upon and in conformity with written information
                                furnished to the Company by or on behalf of any
                                Purchaser expressly for use therein, and will
                                reimburse the Company, each of its directors,
                                each of its officers who signed the

                                      13.
<PAGE>   14

                                Registration Statement or controlling person for
                                any legal and other expense reasonably incurred
                                by the Company, each of its directors, each of
                                its officers who signed the Registration
                                Statement or controlling person in connection
                                with investigating, defending, settling,
                                compromising or paying any such loss, claim,
                                damage, liability, expense or action. The
                                liability of a Purchaser under this Section 9(c)
                                shall be limited to an amount equal to the
                                aggregate amount such Purchaser paid for the
                                Shares purchased to this Agreement.

                        (d)     Promptly after receipt by an indemnified party
                                under this Section 9 of notice of the threat or
                                commencement of any action, such indemnified
                                party will, if a claim in respect thereof is to
                                be made against an indemnifying party under this
                                Section 9 promptly notify the indemnifying party
                                in writing thereof; but the omission so to
                                notify the indemnifying party will not relieve
                                it from any liability which it may have to any
                                indemnified party for contribution or otherwise
                                than under the indemnity agreement contained in
                                this Section 9 or to the extent it is not
                                materially prejudiced as a result of such
                                failure. In case any such action is brought
                                against any indemnified party and such
                                indemnified party seeks or intends to seek
                                indemnity from an indemnifying party, the
                                indemnifying party will be entitled to
                                participate in, and, to the extent that it may
                                wish, jointly with all other indemnifying
                                parties similarly notified, to assume the
                                defense thereof with counsel reasonably
                                satisfactory to such indemnified party;
                                provided, however, if the defendants in any such
                                action include both the indemnified party and
                                the indemnifying party, based upon the advice of
                                such indemnified party's counsel, the
                                indemnified party shall have reasonably
                                concluded that there may be a conflict of
                                interest between the positions of the
                                indemnifying party and the indemnified party in
                                conducting the defense of any such action or
                                that there may be legal defenses available to it
                                and/or other indemnified parties which are
                                different from or additional to those available
                                to the indemnifying party, the indemnified party
                                or parties shall have the right to select
                                separate counsel to assume such legal defenses
                                and to otherwise participate in the defense of
                                such action on behalf of such indemnified party
                                or parties. Upon receipt of notice from the
                                indemnifying party to such indemnified party of
                                its election so to assume the defense of such
                                action and approval by the indemnified party of
                                counsel, the indemnifying party will not be
                                liable to such indemnified party under this
                                Section 9 for any legal or other expenses
                                subsequently reasonably incurred by such
                                indemnified party in connection with the defense
                                thereof unless (i) the indemnified party shall
                                have employed such counsel in connection with
                                the assumption of legal defenses in accordance
                                with the proviso to the preceding

                                      14.
<PAGE>   15

                                sentence (it being understood, however, that the
                                indemnifying party shall not be liable for the
                                expenses of more than one separate counsel,
                                approved by such indemnifying party in the case
                                of paragraph (b), representing all of the
                                indemnified parties who are parties to such
                                action) or (ii) the indemnified party shall not
                                have employed counsel reasonably satisfactory to
                                the indemnified party to represent the
                                indemnified party within a reasonable time after
                                notice of commencement of action, in each of
                                which cases the reasonable fees and expenses of
                                counsel shall be at the expense of the
                                indemnifying party.

                        (e)     If the indemnification provided for in this
                                Section 9 is required by its terms but is for
                                any reason held to be unavailable to or
                                otherwise insufficient to hold harmless an
                                indemnified party under paragraphs (b), (c) or
                                (d) of this Section 9 in respect to any losses,
                                claims, damages, liabilities or expenses
                                referred to herein, then each applicable
                                indemnifying party shall contribute to the
                                amount paid or payable by such indemnified party
                                as a result of any losses, claims, damages,
                                liabilities or expenses referred to herein (i)
                                in such proportion as is appropriate to reflect
                                the relative benefits received by the Company
                                and the Purchaser from the placement of Common
                                Stock or (ii) if the allocation provided by
                                clause (i) above is not permitted by applicable
                                law, in such proportion as is appropriate to
                                reflect not only the relative benefits referred
                                to in clause (i) above but the relative fault of
                                the Company and the Purchaser in connection with
                                the statements or omissions or inaccuracies in
                                the representations and warranties in this
                                Agreement which resulted in such losses, claims,
                                damages, liabilities or expenses, as well as any
                                other relevant equitable considerations. The
                                respective relative benefits received by the
                                Company on the one hand and each Purchaser on
                                the other shall be deemed to be in the same
                                proportion as the amount paid by such Purchaser
                                to the Company pursuant to this Agreement for
                                the Shares purchased by such Purchaser that were
                                sold pursuant to the Registration Statement
                                bears to the difference (the "Difference")
                                between the amount such Purchaser paid for the
                                Shares that were sold pursuant to the
                                Registration Statement and the amount received
                                by such Purchaser from such sale. The relative
                                fault of such Selling Stockholders and each
                                Purchaser shall be determined by reference to,
                                among other things, whether the untrue or
                                alleged statement of a material fact or the
                                omission or alleged omission to state a material
                                fact or the inaccurate or the alleged inaccurate
                                representation and/or warranty relates to
                                information supplied by the Company or by such
                                Purchaser and the parties' relative intent,
                                knowledge, access to information and opportunity
                                to correct or prevent such statement or
                                omission. The amount paid or payable by

                                      15.
<PAGE>   16

                                a party as a result of the losses, claims,
                                damages, liabilities and expenses referred to
                                above shall be deemed to include, subject to the
                                limitations set forth in paragraph (c) of this
                                Section 9, any legal or other fees or expenses
                                reasonably incurred by such party in connection
                                with investigating or defending any action or
                                claim. The provisions set forth in paragraph (c)
                                of this Section 9 with respect to the notice of
                                the threat or commencement of any threat or
                                action shall apply if a claim for contribution
                                is to be made under this paragraph (e);
                                provided, however, that no additional notice
                                shall be required with respect to any threat or
                                action for which notice has been given under
                                paragraph (d) for purposes of indemnification.
                                The Company and each Purchaser agree that it
                                would not be just and equitable if contribution
                                pursuant to this Section 9 were determined
                                solely by pro rata allocation (even if the
                                Purchaser were treated as one entity for such
                                purpose) or by any other method of allocation
                                which does not take account of the equitable
                                considerations referred to in this paragraph.
                                Notwithstanding the provisions of this Section
                                9, no Purchaser shall be required to contribute
                                any amount in excess of the amount by which the
                                Difference exceeds the amount of any damages
                                that such Purchaser has otherwise been required
                                to pay by reason of such untrue or alleged
                                untrue statement or omission or alleged
                                omission. No person guilty of fraudulent
                                misrepresentation (within the meaning of Section
                                11(f) of the Securities Act) shall be entitled
                                to contribution from any person who was not
                                guilty of such fraudulent misrepresentation. The
                                Purchasers' obligations to contribute pursuant
                                to this Section 9 are several and not joint.

                10. BROKER'S FEE. The Purchaser acknowledges that the Company
intends to pay to the Placement Agent a fee in respect of the sale of the Shares
to the Purchaser. Each of the parties hereto hereby represents that, on the
basis of any actions and agreements by it, there are no other brokers or finders
entitled to compensation in connection with the sale of the Shares to the
Purchaser.

                11. NOTICES. All notices, requests, consents and other
communications hereunder shall be in writing, shall be mailed by first-class
registered or certified airmail, confirmed facsimile or nationally recognized
overnight express courier postage prepaid, and shall be deemed given when so
mailed and shall be delivered as addressed as follows:

                        (a)     if to the Company, to:

                                     Daniel L. Kisner, M.D.
                                     President & CEO
                                     Caliper Technologies Corp.
                                     605 Fairchild Drive
                                     Mountain View, CA 94043-2234

                                      16.
<PAGE>   17

                                with a copy to:

                                     Cooley Godward LLP
                                     Five Palo Alto Square
                                     3000 El Camino Real
                                     Palo Alto, CA 94306-2155
                                     Attention: Robert L. Jones, Esq.
                                                Brett D. White, Esq.

                                or to such other person at such other place
                                as the Company shall designate to the
                                Purchaser in writing; and

                        (b)     if to the Purchaser, at its address as set forth
                                at the end of this Agreement, or at such other
                                address or addresses as may have been furnished
                                to the Company in writing.

                12. CHANGES. This Agreement may not be modified or amended
except pursuant to an instrument in writing signed by the Company and the
Purchaser.

                13. HEADINGS. The headings of the various sections of this
Agreement have been inserted for convenience of reference only and shall not be
deemed to be part of this Agreement.

                14. SEVERABILITY. In case any provision contained in this
Agreement should be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained
herein shall not in any way be affected or impaired thereby.

                15. GOVERNING LAW. This Agreement shall be governed by and
construed in accordance with the laws of the State of Delaware without regard to
the conflict of laws and the federal law of the United States of America.

                16. SPECIFIC PERFORMANCE. The parties hereto hereby declare that
it is impossible to measure in money the damages which will accrue to party
hereto or to their assigns by reason of a failure to perform any of the
obligations under this Agreement and agree that the terms of this Agreement
shall be specifically enforceable. If any party hereto or their assigns
institutes any action or proceeding to specifically enforce the provisions
hereof, any person against whom such action or proceeding is brought hereby
waives the claim or defense therein that such party has an adequate remedy at
law, and such person shall not offer in any such action or proceeding the claim
or defense that such remedy at law exists.

                17. COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument, and shall become effective
when one or more counterparts have been signed by each party hereto and
delivered to the other parties.

                                      17.
<PAGE>   18

                IN WITNESS WHEREOF, the parties hereto have caused this
Agreement to be executed by their duly authorized representatives as of the day
and year first above written.

                                            CALIPER TECHNOLOGIES CORP.

                                            --------------------------------
                                            By: Daniel L. Kisner, M.D.
                                            Its: President and Chief Executive
                                            Officer

--------------------------------            --------------------------------
Name of Purchaser (Individual or            Name of Individual representing
  Institution)                              Purchaser (if an Institution)

--------------------------------            --------------------------------
Title of Individual representing            Signature of Individual Purchaser or
  Purchaser (if an Institution)             Individual representing Purchaser

                                            Address:

                                            --------------------------------

                                            Telephone:

                                            --------------------------------

                                            Telecopier:

                                            --------------------------------

<TABLE>
<CAPTION>
                                     Price Per
       Number to Be                  Share In         Aggregate
        Purchased                    Dollars            Price
        ---------                    -------            -----
       <S>                           <C>              <C>
                                                        $

</TABLE>

                                      18.
<PAGE>   19

APPENDIX I
(one of two)

                           CALIPER TECHNOLOGIES CORP.

                         STOCK CERTIFICATE QUESTIONNAIRE

        Please provide us with the following information as per Section 3 of the
Agreement.

1.      The exact name that your Shares are to be registered in (this is the
        name that will appear on your stock certificate(s)). You may use a
        nominee name if appropriate:

        ------------------------------------------

2.      The relationship between the Purchaser of the Shares and the Registered
        Holder listed in response to item 1 above:

        ------------------------------------------

3.      The mailing address of the Registered Holder listed in response to item
        1 above:

        ------------------------------------------

        ------------------------------------------

        ------------------------------------------

        ------------------------------------------

4.      The Social Security Number or Tax Identification Number of the
        Registered Holder listed in response to item 1 above:

        ------------------------------------------

                                      19.
<PAGE>   20

APPENDIX I
(two of two)

                           CALIPER TECHNOLOGIES CORP.
                      REGISTRATION STATEMENT QUESTIONNAIRE

                In connection with the preparation of the Registration
Statement, please provide us with the following information:

                1. Pursuant to the "Selling Shareholder" section of the
Registration Statement, please state your or your organization's name exactly as
it should appear in the Registration Statement:

       ------------------------------------------------------------------

                2. Please provide the number of shares that you or your
organization will own immediately after Closing, including those Shares
purchased by you or your organization pursuant to this Purchase Agreement and
those shares purchased by you or your organization through other transactions:

       -------------------------------------------------------------------

                3. Have you or your organization had any position, office or
other material relationship within the past three years with the Company or its
affiliates?

                [ ] Yes         [ ] No

                If yes, please indicate the nature of any such relationships
below:

-----------------------------------------------------------------

-----------------------------------------------------------------

-----------------------------------------------------------------

                                      20.
<PAGE>   21

APPENDIX II

Attention:
           --------------------------

                   PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

The undersigned, [an officer of, or other person duly authorized by]

-----------------------------------------------------------------
      [fill in official name of individual or institution]

hereby certifies that he/she [said institution] is the Purchaser of the shares
evidenced by the attached certificate,

and as such, sold such shares on                    in accordance
                                 ------------------

Registration Statement number
                              --------------------------------------------------
                                       [fill in the number of or otherwise

-------------------------------- and the requirement of delivering a identify
Registration Statement] current prospectus by the Company has been complied with
in connection with such sale.

Print or Type:

         Name of Purchaser
         (Individual or Institution):
                                             -------------------------------

         Name of Individual representing
         Purchaser (if an Institution):
                                             -------------------------------

         Title of Individual representing
         Purchaser (if an Institution):
                                             -------------------------------

Signature by:

         Individual Purchaser or Individual representing Purchaser:

         ---------------------------------

                                      21.
<PAGE>   22

                             SCHEDULE OF PURCHASERS

<TABLE>
<CAPTION>
                    PURCHASER                                                             NUMBER OF SHARES
                    ---------                                                             ----------------
<S>                                                                                       <C>
Caduceus Capital Trust                                                                              35,000

Caduceus Capital II, L.P.                                                                           48,500

PW Eucalyptus Fund, LLC                                                                             75,000

PW Eucalyptus Fund, Ltd.                                                                             5,000

Finsbury Worldwide Pharmaceutical Trust                                                             36,500

Eaton Vance Worldwide Health Sciences Portfolio                                                    200,000

DWS Investment                                                                                     250,000

Alliance Select Investors Series-Biotechnology Portfolio                                           200,000

Berger Small Company Growth Fund                                                                   150,000

Berger IPT - Small Company Growth Fund                                                                 500

Berger New Generation Fund                                                                          37,250

Berger IPT - New Generation Fund                                                                       250

Berger Mid Cap Growth Fund                                                                          12,000

SMALLCAP World Fund, Inc.                                                                          200,000

The Kaufmann Fund                                                                                  200,000

Lone Balsam, L.P.                                                                                   15,800

Lone Sequoia, L.P.                                                                                  13,200

Lone Spruce, L.P.                                                                                    7,200

Lone Cypress, Ltd.                                                                                 163,800

Baystar International, LTD                                                                          37,500

Baystar Capital, L.P.                                                                               87,500

UBS O'Connor LLC f/b/o UBS Global Equity Arbitrage Master Limited                                  100,000

Galleon Healthcare Offshore, Ltd.                                                                   42,500

Galleon Healthcare Partners, L.P.                                                                   42,500

Phoenix - Engemann Small & Mid-Cap Growth Fund                                                      45,780

Phoenix - Engemann Small Cap Fund                                                                   39,000

The Phoenix Edge Series Fund: Phoenix - Engemann Small & Mid-Cap Growth Series                         220

S.A.C. Capital Associates, LLC                                                                      45,000

S.A.C. Healthco Fund, LLC                                                                           30,000

Clariden Biotechnology Equity Fund                                                                  40,000

3i Bioscience Investment Trust PLC                                                                  30,000

United Capital Management, Inc.                                                                     30,000

Investment 10 LLC                                                                                    1,600

Biotechnology Value Fund II, L.P.                                                                    8,000

Biotechnology Value Fund, L.P.                                                                      10,400

KBC Asset Management                                                                                20,000

Narragansett I, LP                                                                                   8,600

Narragansett Offshore, Ltd.                                                                         11,400

The Aries Master Fund II                                                                            11,673

Aries Domestic Fund, L.P.                                                                            6,347

Aries Domestic Fund II, L.P.                                                                         1,980
</TABLE>

                                      22.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00015-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00015-of-00352.parquet"}]]