Document:

EXHIBIT 10.2

PARENT COMPANY GUARANTEE

 

This is a first demand autonomous guarantee
(garanzia autonoma a prima richiesta) (the "Guarantee"), dated as of 5 December 2022, given by

		(1)	Capri Holdings Limited, a company limited by shares, incorporated under the laws of the British
Virgin Island, with registered office at Vistra Corporate Services Centre, Wickhams Cay II, Road Town, Tortola, British Virgin Islands
and with business company number: 524407 (the "Guarantor"),

in the interest of the Company (as defined
below) and in favour and for the rateable benefit of:

		(2)	Banca Nazionale del Lavoro S.p.A., a joint stock company (società per azioni) incorporated
under the laws of the Republic of Italy, with its registered office in Viale Altiero Spinelli 30, Rome, Italy, share capital of Euro 2,076,940,000
fully paid in, tax code, VAT and registration with the Companies Register of Rome No. 09339391006, ("BNL");

		(3)	Intesa Sanpaolo S.p.A., a joint stock company (società per azioni) with registered
office in Turin, Piazza San Carlo n. 156, corporate capital equal to Euro 10,084,445,147.92 fully paid up, with tax code and registration
number in the Registry of Enterprises of Turin with number 00799960158, group VAT number 11991500015 (IT11991500015), enrolled with the
registry of the banks held by the Bank of Italy under n. 5361, parent company of the Gruppo Bancario Intesa Sanpaolo, enrolled in the
Albo dei gruppi bancari, adhering at Fondo Interbancario di Tutela dei Depositi and at Fondo Nazionale di Garanzia,
("ISP");

		(4)	UniCredit S.p.A., a company incorporated in Italy as a "società per azioni",
having its registered office and head office in Piazza Gae Aulenti, 3, Tower A, 20154 Milan, corporate capital equal to Euro 21,220,169,840.48,
fully paid in, registered with the "Albo delle Banche and the Albo dei Gruppi Bancari" under the number 02008.1, number
of registration with the Companies Register of Milano-Monza-Brianza-Lodi, tax code and VAT number 00348170101, registered with the "Fondo
Interbancario di Tutela dei Depositi" and the "Fondo Nazionale di Garanzia" ("UCI" and together
with BNL and ISP the "Original Lenders"), and

any of their universal successors (successore
a titolo universale), transferees (cessionario) or assignees (avente causa) pursuant to the terms of the Facility Agreement
(as defined below) or by law (the "Beneficiaries").

WHEREAS:

		(A)	as at the date of this Guarantee, the Guarantor holds indirectly an overall participation equal to 100%
of the corporate capital of Gianni Versace S.r.l., a limited liability company (società a responsabilità limitata)
incorporated under the laws of the Republic of Italy, with registered office at Piazza Luigi Einaudi, 4 Milan, tax code and No. of registration
with Companies’ Register of Milano – Monza Brianza – Lodi: 04636090963 (the "Company");

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		(B)	on 5 December 2022, the Company, as borrower, has entered into a term loan facility agreement (the "Facility
Agreement"), with Banca Nazionale del Lavoro S.p.A., Intesa Sanpaolo S.p.A. and Unicredit S.p.A. as mandated lead arrangers,
Intesa Sanpaolo S.p.A. as agent (the "Agent"), and the Original Lenders;

		(C)	under and pursuant to the Facility Agreement, the Original Lenders have made available to the Company
a term facility for an aggregate amount up to euro 450,000,000.00 (the "Facility"), upon the terms and subject to the
conditions set forth therein;

		(D)	upon request of the Beneficiaries, the Guarantor has agreed to guarantee the payment obligations of the
Company to the Beneficiaries under the Finance Documents (as defined in the Facility Agreement) in the manner hereafter set out.

NOW THEREFORE, the parties hereby agree
as follows:

DEFINITIONS AND INTERPRETATION

Unless defined in this Guarantee or the context
provides otherwise, the terms defined in the Facility Agreement used in this Guarantee, or in any notice given under or in connection
with this Guarantee, shall bear the same meaning ascribed to them in the Facility Agreement.

TERMS AND CONDITIONS

		1.	First demand autonomous guarantee

		1.1	Subject to Clause 3 (Payment mechanics) below, the Guarantor hereby unconditionally and irrevocably
guarantees to the Beneficiaries, upon first demand and without the need for any prior action and waiving any challenge and defence, the
due and punctual performance by the Company of all the Company’s payment obligations (including default interest, fees and costs)
under the Finance Documents (the "Guaranteed Obligations"), when and as the same shall become due and payable in accordance
with the terms thereof, in any case up to the Maximum Guaranteed Amount (as defined below).

		1.2	This Guarantee is a first demand autonomous guarantee (garanzia autonoma a prima richiesta) and
not a "fideiussione", independent and separate from the obligations of the Borrower and is a continuing guarantee which
will extend to the ultimate balance of sums payable by the Borrower under the Finance Documents, regardless of any intermediate payment
or discharge in whole or in part. The Guarantor therefore in relation to this Guarantee expressly and irrevocably: (a) agrees that the
Beneficiaries may proceed against the Guarantor to enforce this Guarantee without taking any prior action against the Company, and (b)
waives the benefits, rights and exceptions under articles 1247, 1939, 1941, 1944, 1945, 1949, 1955, 1956 and 1957 of the Italian Civil
Code, as well as any other right, remedy, exception and/or defence, including based on any claims that the Company or any third party
may have against the Beneficiaries and/or any claim based on the validity and effectiveness of any of the relationship arising out of
the Finance Documents, and/or any claims the Guarantor or the Company may have based on any applicable law or regulation of any jurisdiction.

		1.3	The Guarantor’s obligations under this Guarantee will not be released, reduced, prejudiced or diminished
by: (i) any time, indulgence or concession given by the

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Beneficiaries to the Company in relation
to the Guaranteed Obligations; (ii) any invalidity, ineffectiveness, or other defect of any kind (including, without limitations, unenforceability
and/or illegality) of or relating to the Facility Agreement or the Guaranteed Obligations; (iii) any variation, amendment, supplement,
extension, waiver or release at any time entered into or granted in respect of the Finance Documents or any of the Guaranteed Obligations;
(iv) the insolvency, administration, liquidation of, or administration order in relation to, the Company; and/or (v) any change in the
Guarantor’s participation, whether direct or indirect, in the corporate capital of the Company.

		2.	Maximum Guaranteed Amount

The maximum aggregate liability of the
Guarantor, according to this Guarantee, shall not exceed euro 675,000,000.00 (six hundred and seventy-five million/00) (the "Maximum
Guaranteed Amount") and, beyond that limit, the Guarantor will not have liability of any kind to the Beneficiaries hereunder
regarding any kind of claim whether in principal, interests, costs, expenses, fees or other sums due.

		3.	Payment mechanics

		3.1	Any Beneficiaries’ demand under this Guarantee shall be made in writing by the Agent in the form
set out in Schedule 1 (Form of Payment Demand) (the "Payment Demand") and shall state the unpaid amount due for
payment.

		3.2	The Payment Demand shall be sent together with (i) a statement that the Beneficiaries are calling upon
the Guarantor to pay under this Guarantee; and (ii) a statement by the Agent that the amount claimed is due and payable under the Finance
Documents, it being understood that in no event shall the aggregate amount under all Payment Demands made hereunder exceed the Maximum
Guaranteed Amount.

		3.3	Any payment due by the Guarantor hereunder shall be made within 5 (five) Business Days (as this term is
defined below) of receipt of the Payment Demand, without any set-off, assertion of defence or counterclaim pursuant to the Finance Documents
or otherwise, and via bank transfer to the bank account which shall be indicated by the Beneficiaries, acting through the Agent, in writing.
Each payment made under this Guarantee shall be paid without any deduction or withholding for or on account of tax (a "Tax Deduction")
unless a Tax Deduction is required by law. If a Tax Deduction is required by law to be made, the amount of the payment due shall be increased
to an amount which (after making any Tax Deduction) leaves an amount equal to the payment which would have been due if no Tax Deduction
had been required.

		3.4	All payment made under this Guarantee are exclusive of any value added tax or similar charge ("VAT").
If VAT is chargeable, the Guarantor shall also and at the same time pay to the recipient of the relevant payment an amount equal to the
amount of the VAT.

		3.5	If the Guarantor fails to pay any amount payable by it under this Guarantee on its due date, interest
shall accrue on the overdue amount from the due date up to the date of actual payment at a rate equal to 2% per annum ("Default
Interest").

		3.6	This Guarantee may be enforced one or more times, even partially, up to the Maximum Guaranteed Amount.
It is understood that any payment made for the benefit of the

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Beneficiaries pursuant to this Guarantee
will reduce the Maximum Guaranteed Amount for an amount equal to the amount actually paid under any Payment Demand.

		4.	Representations of the Guarantor

		4.1	The Guarantor represents to each Beneficiary that:

		(a)	it is a corporation, duly incorporated, validly existing and in good standing under the law of its jurisdiction
of incorporation;

		(b)	it has the power to own its assets and carry on its business as it is being conducted;

		(c)	the persons executing this Guarantee have been duly empowered to do so by the Guarantor’s
competent corporate bodies;

		(d)	it has the power to enter into, perform and deliver, and has taken all necessary actions to authorise
the entry into, the performance and the delivery of, the Guarantee and the transactions contemplated by it;

		(e)	the obligations expressed to be assumed by it under the Guarantee are legal, valid, binding and enforceable
obligations;

		(f)	the entry into and performance by it of, and the transactions contemplated by, the Guarantee do not and
will not conflict with (a) any law or regulation applicable to it; (b) its constitutional documents; or (c) any agreement or instrument
binding upon it;

		(g)	all authorisations required or desirable:

		(i)	to enable it lawfully to enter into, exercise its rights and comply with its obligations under the Guarantee;
and

		(ii)	to make the Guarantee admissible in evidence in its jurisdiction of incorporation,

have been obtained or effected and are
in full force and effect;

		(h)	the choice of Italian law as the governing law of the Guarantee will be recognised and enforced in its
jurisdiction of incorporation;

		(i)	any judgment obtained in Italy in relation to the Guarantee will be recognised and enforced in its jurisdiction
of incorporation;

		(j)	its payment obligations under the Guarantee rank at least pari passu with the claims of all its
other unsecured and unsubordinated creditors, except for obligations mandatorily preferred by law applying to companies generally;

		(k)	it has a good, valid and marketable title to, or valid leases or licences of, and all appropriate authorisations
to use, the assets necessary to carry on its business as presently conducted; and

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		(l)	no corporate action, legal proceedings or other procedure or step is taken in relation to:

		(i)	the suspension of payments, a moratorium of any indebtedness, winding-up, dissolution, administration
or reorganisation (by way of voluntary arrangement, scheme of arrangement or otherwise);

		(ii)	a composition, compromise, assignment or arrangement with any of its creditor;

		(iii)	the appointment of a liquidator, receiver, administrative receiver, administrator, compulsory manager
or other similar officer in respect of it or any of its assets; or

		(iv)	enforcement of any Security (as defined under the Facility Agreement) over any of its assets,

or any analogous procedure or step is taken
in its jurisdiction.

		4.2	With respect to itself and the Guarantor Group (as defined under the Facility Agreement), the Guarantor
makes in favour of each Beneficiary the representations set out under clauses 17.21 (Sanctions), 17.22 (Anti-bribery and corruption)
and 17.23 (Anti-Money Laundering) of the Facility Agreement.

		4.3	The representations set out in letters (a) to (k) of this Clause 4 and in Clause 4.2 are deemed to be
repeated by the Guarantor (by reference to the facts and circumstances then existing) on the date of the Utilisation Request and the first
day of each Interest Period (each term as defined under the Facility Agreement).

		5.	Undertakings of the Guarantor

		5.1	The Guarantor hereby confirms that it has received a copy of the Facility Agreement and acknowledges the
terms and conditions set out thereunder, including, without limitation, the representations made, and the undertakings assumed, by the
Company pursuant to the Facility Agreement (including, without limitation, the undertaking set out in clause 19 (Financial covenants)
of the Facility Agreement).

		5.2	The Guarantor undertakes to provide the Company promptly with any documents, details and/or information
that the Company is required to supply to the Agent pursuant to the Facility Agreement.

		6.	Agent of the Beneficiaries

		6.1	The Guarantor and the Beneficiaries acknowledge that the Agent represents the Beneficiaries (jointly and
severally) and acts as their agent (mandatario con rappresentanza) under and in connection with the execution and any amendment
of this Guarantee and the constitution, acknowledgement, extension, release and enforcement of this Guarantee (but excluding, for the
avoidance of any doubts, representation in connection with judicial litigation). The Agent (acting on the instructions and with the prior
consent of all the Beneficiaries) may execute, negotiate and despatch any document for and on behalf of the Beneficiaries and exercise
each and every right, power, authority and discretion granted to the Beneficiaries pursuant to this Guarantee

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in their name and on their behalf (in
nome e per conto), with the express consent pursuant to articles 1394 and 1395 of the Italian Civil Code.

		6.2	The Guarantor shall send any notice (even if addressed to the other Beneficiaries or any of them, as the
case may be) to the Agent. Any notice from the Agent in relation to this Guarantee shall be deemed to be from the other Beneficiaries
also unless the notice states otherwise.

		7.	Miscellaneous

		7.1	If any discharge, release or arrangement is made by a Beneficiary in whole or in part on the basis of
any payment, security or other disposition which is avoided or must be restored in insolvency, liquidation, administration or otherwise,
without limitation, then the liability of the Guarantor under this Guarantee will continue or be reinstated as if the discharge, release
or arrangement had not occurred.

		7.2	No failure to exercise, nor any delay in exercising, on the part of the Agent, any right or remedy under
this Guarantee shall operate as a waiver of any such right or remedy No single or partial exercise of any right or remedy shall prevent
any further or other exercise or the exercise of any other right or remedy. The rights and remedies provided under this Guarantee are
cumulative and not exclusive of any rights or remedies provided by law.

		7.3	The Guarantor shall not be entitled to assign or transfer all or part of its obligations under this Guarantee,
without the previous written consent of the Beneficiaries.

		7.4	No amendment, modification or waiver in respect of this Guarantee shall be effective unless, such amendment,
modification or waiver is made in writing and signed by the Guarantor and the Agent (acting on the instructions of all the Beneficiaries).

		7.5	This Guarantee is in addition to and will not affect or be affected by any other security or other right
the Beneficiaries may have at any time against the Company, the Guarantor or any other person in respect of all or any part of the Facility
Agreement or the Guaranteed Obligations.

		7.6	Any communication to be made under or in connection with this Guarantee (including, but not limited to,
the Payment Demand) shall be made by registered letter with acknowledgement of receipt, e-mail or registered email (PEC) to the following
addresses:

		(a)	in the case of the Guarantor, at the registered office of the Company at which it elects domicile, as
set out below:

Gianni Versace S.r.l.

		address:	Piazza Einaudi, 4
	 	 	20124 Milan
	 	e-mail:	marco.gilardi@versace.it
	 	 	andrea.tripodo@capriholdings.com
	 	PEC:	gianniversace@pecversace.it
	 	attention of:	CFO and Senior
Manager Treasury

 

 

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Copy to:

Capri Holdings Limited

		address:	33 Kingsway
	 	 	WC2B 6UF London

                                                              United Kingdom

	 	e-mail:	david.provenzano@capriholdings.com
	 	attention of:	David Provenzano

 

		(b)	in the case of the Agent/Beneficiaries

		address:	Largo Mattioli, 3
	 	 	

20121 Milan

Italy

		e-mail:	manuela.galeazzi@intesasanpaolo.com
	 	 	antonella.cavallo@intesasanpaolo.com
	 	PEC:	imi.loanagency@pec.intesasanpaolo.com
	 	attention of:	Manuela Galeazzi / Antonella Cavallo
	 	 	 

		8.	Governing Law and Jurisdiction

		8.1	This Guarantee and any non-contractual obligations arising out of or in connection with it are governed
by Italian law.

		8.2	The courts of Milan have exclusive jurisdiction to settle any dispute arising out of or in connection
with this Guarantee (including a dispute relating to the existence, validity or termination of this Guarantee or any non-contractual obligation
arising out of or in connection with this Guarantee) (a "Dispute"). The Parties agree that the courts of Milan are the
most appropriate and convenient courts to settle Disputes and accordingly no Party will argue to the contrary

		8.3	Notwithstanding paragraph 8.2 above, no Beneficiary shall be prevented from taking proceedings relating
to a Dispute in any other courts with jurisdiction. To the extent allowed by law, the Beneficiaries may take concurrent proceedings in
any number of jurisdictions.

 

 

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Schedule
1

Form of Payment
Demand

 

 

 

 

 

 

 

    	 	8	 

     

    

 

We hereby notify you of our acceptance of the
parent company guarantee set out above.

 

Yours sincerely

 

Capri Holdings Limited

 

 

	/s/ David Provenzano	 
	By:	David Provenzano	 
	Title:	SVP, Tax and Risk Management, Treasurer	 

 

 

 

 

    	 	9	 

     

    

 

* * *

 

Should you agree with the above proposal, please manifest your acceptance
thereof by sending us a letter which reproduces the contents of this letter and of the parent company guarantee, duly signed by way of
acceptance by a representative authorized to bind your company.

 

Yours sincerely 

 

Intesa Sanpaolo S.p.A.

 

 

	/s/ Manuela Fornoni	
	By:	 Manuela Fornoni	 
			 

5
dicembre 2022

 

 

 

 

    	 	10	 

     

    

 

We hereby notify you of our acceptance of the parent company guarantee
set out above.

 

Yours sincerely 

 

Banca Nazionale de Lavoro
S.p.A.

 

 

	/s/ Francesca D’Alberto	 	/s/ Rocco Pellegrino	 
	By:	Francesca D’Alberto	 	By:	Rocco Pellegrino	 
		 	 	 	 	 

 

 

 

 

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We hereby notify you of our acceptance of the parent company guarantee
set out above.

 

Yours sincerely 

 

UniCredit S.p.A.

 

 

	/s/ Luca De Dominicis	 	/s/ Leonardo Cartei	 
	By:	Luca De Dominicis	 	By:	Leonardo Cartei	 
		 	 	 	 	 

 

 

 

 

    	 	12notepurchaseagreementpre

  4891-4787-1298.2  NOTE PURCHASE AGREEMENT  This NOTE PURCHASE AGREEMENT (this “Agreement”) is made and entered into  as of December 6, 2022 by and among Summit Therapeutics Inc., a Delaware corporation,  with its principal place of business at 2882 Sand Hill Road, Suite 106, Menlo Park, CA   94025 (the “Company”), and each investor named on Exhibit A hereto (each, an “Investor”  and, collectively, the “Investors”).   RECITALS   A. The Company and the Investors are executing and delivering this Agreement  in reliance upon the exemption from securities registration afforded by the provisions of  Regulation D, as promulgated by the U.S. Securities and Exchange Commission (the “SEC”)  under the Securities Act of 1933, as amended;    B. This Agreement establishes a credit facility for the Company to sell to each  Investor, and for each Investor to purchase, subject to the other conditions precedent and the  other terms and conditions of this Agreement, a Promissory Note, each substantially in the  form attached hereto as Exhibits B-1, B-2 and B-3 (each, a “Note”, and, collectively, the  “Notes”), at the Closing (as such term is defined herein);   C. The aggregate outstanding principal amount of Notes issued and purchased by  the Investors at the Closing shall equal $520,000,000 (the “Maximum Principal Amount”).   D. Each Note, whenever issued, shall mature and come due on the maturity date  set forth in such Note (each such date, the “Maturity Date”), and each Note sets forth other  terms and conditions as to which the credit facility is subject; and  E. This Agreement, the Notes, and all other certificates, agreements, documents  and instruments delivered to any party under or in connection with this Agreement, as the  same may be amended from time to time, are collectively referred to herein as the  “Transaction Documents”.   In consideration of the mutual promises made herein and for other good and valuable  consideration, the receipt and sufficiency of which are hereby acknowledged, the parties  hereto agree as follows:   1. Definitions.  For the purposes of this Agreement, the following terms shall  have the meanings set forth below:   “Affiliate” means, with respect to any Person, any other Person which directly or  indirectly through one or more intermediaries controls, is controlled by, or is under common  control with, such Person. A Person shall be deemed to control another Person if such Person  possesses, directly or indirectly, the power to direct or cause the direction of the management  and policies of such Person, whether through the ownership of voting securities, by contract  or otherwise.  Without limiting the generality of the foregoing, a Person shall be deemed to  control another Person if any of the following conditions is met: (i) in the case of corporate  entities, direct or indirect ownership of more than fifty percent (50%) of the stock or shares  having the right to vote for the election of directors, and (ii) in the case of non-corporate  entities, direct or indirect ownership of more than fifty percent (50%) of the equity interest  with the power to direct the management and policies of such non-corporate entities  

 

  2  4891-4787-1298.2  “Agreement” has the meaning set forth in the preamble to this Agreement.  “Board” means the Company’s Board of Directors.  “Business Day” means a day, other than a Saturday, Sunday or United States federal  holiday, on which banks in New York City are open for the general transaction of business.  “Closing” has the meaning set forth in Section 3.1.  “Closing Date” has the meaning set forth in Section 3.1.  “Common Stock” has the meaning set forth in Section 4.2 to this Agreement.  “Common Stock Equivalents” shall mean any options, warrants or other securities or  rights convertible into or exercisable or exchangeable for, whether directly or following  conversion into or exercise or exchange for other options, warrants or other securities or  rights, Common Stock of the Company, or any swap, hedge or similar agreement or  arrangement that transfers in whole or in part, the economic risk of ownership of, or voting or  other rights of, Common Stock.  “Company” has the meaning set forth in the preamble to this Agreement.  “Debt” means, as to any Person, whether or not contingent but without duplication:   (a) every obligation of such Person for money borrowed; (b) every obligation of such Person  evidenced by bonds, debentures, notes or other similar instruments; (c) every obligation of such  Person with respect to letters of credit, bankers’ acceptances or similar facilities issued for the  account of such Person; (d) every obligation of such Person issued or assumed as the deferred  purchase price of property or services (excluding trade accounts payable or accrued liabilities  arising in the ordinary course of business); (e) every obligation of such Person under any lease  which under GAAP (for this purpose without giving effect to the adoption of Accounting  Standards Update No. 2016-02, Leases (Topic 842) by the Financial Accounting Standards  Board) is required to be capitalized as an obligation on a balance sheet of the Person in  question; (f) the net obligations of such Person under any swap contract, derivatives contract  or other hedge agreement; and (g) every obligation, contingent or otherwise, of such Person  guaranteeing, or having the economic effect of guarantying or otherwise acting as surety for,  any obligation of another Person of the type described in clauses (a) through (f) above, in any  manner, whether directly or indirectly.  “Disposition” or “Dispose of” shall mean any (i) pledge, sale, contract to sell, sale of  any option or contract to purchase, purchase of any option or contract to sell, grant of any  option, right or warrant for the sale of, or other disposition of or transfer of any Common  Stock or any Common Stock Equivalents, including, without limitation, any “short sale” or  similar arrangement, or (ii) swap or any other agreement or any transaction that transfers, in  whole or in part, directly or indirectly, the economic consequence of ownership of the  Common Stock or any Common Stock Equivalents, whether any such swap or transaction is  to be settled by delivery of securities, in cash or otherwise.  “Domestication” shall mean the process by which the Company was formally  confirmed as the successor issuer to Summit Therapeutics plc pursuant to a United Kingdom  court-approved scheme of arrangement effective as of September 18, 2020.  “Enforceability Exceptions” has the meaning set forth in Section 4.4(b).   

 

  3  4891-4787-1298.2  “Equity Interests” means shares of capital stock, partnership interests, membership  interests in a limited liability company, beneficial interests in a trust or other equity  ownership interests in a Person, and any warrants, options or other rights entitling the holder  thereof to purchase or acquire any such Equity Interest.   “Extended Maturity Date” means, as to each Note, the “Extended Maturity Date” as  defined in such Note.  “GAAP” means generally accepted accounting principles in the United States set  forth in the opinions and pronouncements of the Accounting Principles Board and the  American Institute of Certified Public Accountants and statements and pronouncements of  the Financial Accounting Standards Board or such other principles as may be approved by a  significant segment of the accounting profession in the United States, that are applicable to  the circumstances as of the date of determination, consistently applied.  “Governmental Authority” shall mean any court, agency, authority, department,  regulatory body or other instrumentality of any government or country or of any national,  federal, state, provincial, regional, county, city or other political subdivision of any such  government or country or any supranational organization of which any such country is a  member.  “Group” means the Company and its subsidiaries (and “Group Company” shall be  construed accordingly).  “Interest Rate” means, as to each Note, the “Interest Rate” as defined in such Note.   “Investor” and “Investors” has the meaning set forth in the preamble to this  Agreement.  “Investor A” means Robert W. Duggan, and his successors or assigns.  “Investor B” means Mahkam Zanganeh, and her successors or assigns.  “Law” or “Laws” shall mean all laws, statutes, rules, regulations, orders, judgments,  injunctions and/or ordinances of any Governmental Authority.  “Majority Investors” means, as of any date of determination, Investors holding Notes  evidencing more than 50.00% of the aggregate outstanding principal amount of the Notes.  “Material Adverse Effect” means a material adverse effect on (i) the assets, liabilities,  results of operations, financial condition or business of the Company and its subsidiaries  taken as a whole, (ii) the legality or enforceability of this Agreement or (iii) the ability of the  Company to perform its obligations under this Agreement.    “Maturity Date” has the meaning set forth in the recitals to this Agreement.  “Maximum Principal Amount” has the meaning set forth in the preamble to this  Agreement.  “Nasdaq” means The Nasdaq Stock Market LLC.  

 

  4  4891-4787-1298.2  “Net Cash Proceeds” means in connection with any issuance or sale of Equity  Interests or any incurrence of Debt, the cash proceeds received from such issuance or  incurrence, net of attorneys' fees, investment banking fees, accountants' fees, underwriting  discounts and commissions and other customary fees and expenses actually incurred in  connection therewith.  “Note” and “Notes” has the meaning set forth in the preamble to this Agreement.  “Other Agreements” means, collectively, (a) all existing and future agreements and  instruments between, among or by the Company (or an Affiliate), on the one hand, and an  Investor (or an Affiliate), on the other hand, and (b) any financing agreement or a material  agreement that affects the Company’s ongoing business operations.  “Person” means an individual, corporation, partnership, limited liability company,  trust, business trust, association, joint stock company, joint venture, sole proprietorship,  unincorporated organization, Governmental Authority or any other form of entity not  specifically listed herein.  “Press Release” has the meaning set forth in Section 10.7.  “Purchase Price” has the meaning set forth in Section 2.1.  “Sarbanes-Oxley Act” has the meaning set forth in Section 4.10(g).  “SEC” has the meaning set forth in the recitals to this Agreement.  “SEC Documents” has the meaning set forth in Section 4.10(a).  “Short Sales” means all “short sales” as defined in Rule 200 of Regulation SHO under  the 1934 Act (but shall not be deemed to include the location and/or reservation of  borrowable Common Stock).  “Third Party” shall mean any Person, including a Governmental Authority, other than  the Investor, the Company or any Affiliate of the Investor or the Company or any of their  respective representatives.  “Trading Day” shall mean a day on which trading in the Common Stock generally  occurs on Nasdaq.  “Transaction Documents” has the meaning set forth in the recitals to this Agreement.  “1933 Act” means the Securities Act of 1933, as amended, or any successor statute,  and the rules and regulations promulgated thereunder.   “1934 Act” means the Securities Exchange Act of 1934, as amended, or any successor  statute, and the rules and regulations promulgated thereunder.   “8-K Filing” has the meaning set forth in Section 10.7.  2. Issuance, Maturity, Prepayment.  

 

  5  4891-4787-1298.2  2.1. Purchase and Sale of the Notes.  Subject to the terms and conditions  of this Agreement, each Investor hereby agrees to purchase, and the Company agrees to issue  and sell to each Investor, at the Closing provided for in Section 3, Notes in the principal  amounts specified in the Notes at the purchase price of 100% of the principal amount thereof.   The Investors’ obligations hereunder are several and not joint obligations. No Investor shall  have any liability to any Person for the performance or non-performance of any obligation by  any other Investor hereunder.   2.2. Maturity. As provided therein, the entire unpaid principal balance of  each Note shall be due and payable on the respective Maturity Date thereof, or Extended  Maturity Date, if applicable.  2.3. Mandatory Prepayments.  If the Company shall consummate a public  offering (a “Public Offering”), then upon the later to occur of (i) five Business Days after the  Company receives the net cash proceeds therefrom or (ii) May 15, 2023, the Notes attached  as Schedule B-1 and B-2  (the “February Notes”) shall be prepaid by an amount equal to the  lesser of (x) 100% of the amount of the net cash proceeds from such Public Offering, and (y)  the principal amount on such Notes, as set forth in this Section 2.  2.4. Partial Prepayments.  In the case of each partial prepayment of Notes  pursuant to Section 2.3, the principal amount of the Notes to be prepaid shall be allocated  among the February Notes at the time outstanding in proportion, as nearly as practicable, to  the respective unpaid principal amounts thereof not theretofore called for prepayment.  2.5. Maturity; Surrender; Etc.  In the case of each prepayment of any  Note, as provided in such Note, the principal amount of each Note to be prepaid shall mature  and become due and payable on the date fixed for such prepayment, together with interest on  such principal amount accrued to such date.  From and after such date, unless the Company  shall fail to pay such principal amount when so due and payable, together with all accrued  interest, interest on such principal amount shall cease to accrue.  Any Note paid or prepaid in  full shall be surrendered to the Company and cancelled and shall not be reissued, and no Note  shall be issued in lieu of any prepaid principal amount of any Note.  2.6. Purchase, etc., of Notes. The Company will not and will not permit  any Affiliate to purchase, redeem, prepay or otherwise acquire, directly or indirectly, any of  the outstanding Notes except (a) upon the payment or prepayment of the Notes in accordance  with this Agreement and the Notes or (b) pursuant to an offer to purchase made by the  Company or an Affiliate pro rata to all Investors at the time outstanding upon the same terms  and conditions.  Any such offer shall provide each holder with sufficient information to  enable it to make an informed decision with respect to such offer, and shall remain open for  at least 10 Business Days.  If the holders of more than 25% of the principal amount of the  Notes then outstanding accept such offer, the Company shall promptly notify the remaining  holders of such fact and the expiration date for the acceptance by holders of Notes of such  offer shall be extended by the number of days necessary to give each such remaining holder  at least 5 Business Days from its receipt of such notice to accept such offer.  The Company  will promptly cancel all Notes acquired by it or any Affiliate pursuant to any payment,  prepayment or purchase of Notes pursuant to this Agreement and no Notes may be issued in  substitution or exchange for any such Notes.  3. Closing.   

 

  6  4891-4787-1298.2  3.1. Closing. The Company’s sale, and an Investor’s purchase, of Notes  shall occur remotely via exchange of documents and signatures, or at such place as the  Company and the Investors purchasing Notes may agree, at a closing (the “Closing”) on  December 6, 2022 (the “Closing Date”).   3.2. At Closing. On the Closing Date, each Investor purchasing a Note at  such Closing shall deliver or cause to be delivered to the Company the Purchase Price owed  by such Investor via wire transfer of immediately available funds pursuant to the wire  instructions delivered to the applicable Investor by the Company in connection with the  execution of this Agreement. At the Closing, the Company shall deliver or cause to be  delivered a Note duly executed by an authorized officer of the Company to the Investor  purchasing such Note.  3.3. Allocations Among Investors. The Notes shall be issued to the  Investors in the amounts specified in the Notes.  4. Representations and Warranties of the Company.  The Company hereby  represents and warrants to each Investor that, except as otherwise described in this  Agreement or the SEC Documents, which qualify these representations and warranties in  their entirety:   4.1. Organization, Good Standing and Qualification.  The Company has  been duly organized and is validly existing and in good standing under the laws of its  jurisdiction of organization, is duly qualified to do business and is in good standing in each  jurisdiction in which its ownership or lease of property or the conduct of its businesses  requires such qualification, and has all power and authority necessary to own or hold its  properties and to conduct the businesses in which it is engaged, except where the failure to be  so qualified or in good standing or have such power or authority would not, individually or in  the aggregate, have a Material Adverse Effect.    4.2. Capitalization and Voting Rights.  (a) As of November 2, 2022, the Company has 201,321,175 shares of the  Company’s common stock, par value $0.01 (the “Common Stock”) issued and outstanding.  As of December 1, 2022, the Company has also (i) granted outstanding options under the  Company’s equity incentive plans over, in aggregate, 23,069,813 shares of Common Stock,  (ii) granted restricted stock units under the Company’s directors’ remuneration policy over 0  shares of Common Stock and (iii) issued warrants for the purchase of up to 5,821,137 shares  of Common Stock, which are outstanding as of December 1, 2022. The issued share capital of  the Company has been duly and validly issued and is fully paid and non-assessable.   (b) Except as described or referred to in Section 4.2(a) above, as of the  date of this Agreement, there are no outstanding rights (including, without limitation, pre- emptive rights), warrants or options to acquire, or instruments convertible into or  exchangeable for, any share capital or other equity interest in the Company, or any contract,  commitment, agreement, understanding or arrangement of any kind relating to the issuance of  any share capital of the Company, any such convertible or exchangeable securities or any  such rights, warrants or options.  

 

  7  4891-4787-1298.2  (c) No Person has any right to cause the Company to effect the  registration under the 1933 Act of any securities of the Company, which have not been  exercised prior to the date hereof.  (d) The Company is not a party to or subject to any agreement or  understanding relating to the voting of share capital of the Company or the giving of written  consents by a stockholder or director of the Company.   (e) The execution and delivery of this Agreement, and the transactions  contemplated hereby, will not result in the triggering of any anti-dilution rights, or otherwise  increase the number of shares of Common Stock issuable or decrease the exercise or  conversion price, under any warrant, option, convertible note or other instruments convertible  or exchangeable for, any share capital or other equity interests in the Company.  4.3. Subsidiaries.  All the outstanding share capital or other equity  interests of each subsidiary owned, directly or indirectly, by the Company have been duly  authorized and validly issued, are fully paid and are owned directly or indirectly by the  Company, free and clear of any lien, charge, encumbrance, security interest, restriction on  voting or transfer or any other claim of any third party.    4.4. Authorization.    (a) The Company has the requisite corporate power and authority to  execute and deliver this Agreement and to perform its obligations hereunder; and all action  required to be taken (including the approval of the Board and of the independent Special  Committee of the Board formed in connection with the Company’s consideration of the  transactions undertaken pursuant to the Transaction Documents) for the due and proper  authorization, execution and delivery by it of this Agreement and the consummation by it of  the transactions contemplated hereby and thereby has been duly and validly taken.   (b) This Agreement and the other Transaction Documents have been duly  executed and delivered by the Company, and this Agreement and the other Transaction  Documents (as and when executed and delivered in accordance with the terms and conditions  of the Agreement) constitute valid and legally binding obligations of the Company,  enforceable against the Company in accordance with their terms, except as enforceability  may be limited by applicable bankruptcy, insolvency or similar laws affecting creditors’  rights generally or by equitable principles relating to enforceability (collectively, the  “Enforceability Exceptions”).  (c) No stop order or suspension of trading of the Company’s equity  securities has been imposed by the SEC, Nasdaq, or any other Governmental Authority and  remains in effect.  4.5. No Defaults.  The Company is not (i) in violation of its certificate of  incorporation or bylaws; (ii) in default, and no event has occurred that, with notice or lapse of  time or both, would constitute such a default, in the due performance or observance of any  term, covenant or condition contained in any indenture, mortgage or loan agreement to which  the Company is a party or by which the Company is bound or to which any of the property or  assets of the Company is subject; (iii) in default, and no event has occurred that, with notice  or lapse of time or both, would constitute such a default, in the due performance or  observance of any term, covenant or condition contained in any deed of trust or other  

 

  8  4891-4787-1298.2  agreement or instrument to which the Company is a party or by which the Company is bound  or to which any of the property or assets of the Company is subject (except for any  agreements referred to in clause (ii) above); or (iv) in violation of any law or statute or any  judgment, order, rule or regulation of any court or arbitrator or governmental or regulatory  authority having jurisdiction over the Company or any of its subsidiaries, except, in the case  of clauses (iii) and (iv) above, for any such default or violation that would not, individually or  in the aggregate, have a Material Adverse Effect.  4.6. No Conflicts.  The execution, delivery and performance of this  Agreement and the consummation of the transactions contemplated hereby will not (i)  conflict with or result in a breach or violation of any of the terms or provisions of, or  constitute a default under, or result in the creation or imposition of any lien, charge or  encumbrance upon any property or assets of the Company pursuant to, any indenture,  mortgage or loan agreement to which the Company is a party or by which the Company is  bound or to which any of the property or assets of the Company is subject, (ii) conflict with  or result in a breach or violation of any of the terms or provisions of, or constitute a default  under, or result in the creation or imposition of any lien, charge or encumbrance upon any  property or assets of the Company pursuant to, any deed of trust or other agreement or  instrument to which the Company is a party or by which the Company is bound or to which  any of the property or assets of the Company is subject (except for any agreements referred to  in clause (i) above), (iii) result in any violation of the provisions of the Company’s certificate  of incorporation or bylaws or (iv) result in the violation of any law or statute or any  judgment, order, rule  or regulation of any court or arbitrator or governmental or regulatory  authority having jurisdiction over the Company or any of its subsidiaries, except, in the case  of clauses (ii) and (iv) above, for any such conflict, breach, violation or default that would  not, individually or in the aggregate, have a Material Adverse Effect.  4.7. No Governmental Authority or Consents.  No consent, approval,  authorization, order, license, registration or qualification of or with any court or arbitrator,  governmental or regulatory authority is required for the execution, delivery and performance  by the Company of this Agreement, or the issuance and sale of the Note, except such filings  as may be required to be made with the SEC or under any state securities laws, foreign  securities laws, blue sky laws, or the rules and regulations of Nasdaq, which filings shall be  made in a timely manner in accordance with all applicable Laws.  4.8. Litigation.  There are no legal, governmental or regulatory  investigations, actions, suits or proceedings pending to which the Company or any of its  subsidiaries is a party or to which any property of the Company or any of its subsidiaries is  subject that, individually or in the aggregate, would reasonably be expected to have a  Material Adverse Effect; and no such investigations, actions, suits or proceedings are  threatened or, to the knowledge of the Company, contemplated by any governmental or  regulatory authority or threatened by others.  4.9. Licenses and Other Rights; Compliance with Laws.  The Company  and its subsidiaries possess or are in the process of obtaining all licenses, certificates, permits  and other authorizations issued by, and have made all declarations and filings with, the  appropriate federal, state, local or foreign governmental or regulatory authorities that are  necessary for the ownership or lease of their respective properties or the conduct of their  respective businesses as described in the SEC Documents, except where the failure to possess  or make the same would not, individually or in the aggregate, have a Material Adverse  Effect; and neither the Company nor any of its subsidiaries has received notice of any  

 

  9  4891-4787-1298.2  revocation or modification of any such license, certificate, permit or authorization or has any  reason to believe that any such license, certificate, permit or authorization will not be  renewed in the ordinary course.   For the avoidance of doubt and notwithstanding the  foregoing, neither the Company nor any subsidiary has applied for or holds any product  licenses or marketing authorizations for any pharmaceutical products.    4.10. SEC Documents; Financial Statements; Nasdaq Stock Market.  (a) Since January 1, 2022, the Company has timely filed all required  reports, schedules, forms, statements and other documents (including exhibits and all other  information incorporated therein), and any required amendments to any of the foregoing, with  the SEC (the “SEC Documents”).  As of their respective filing dates, each of the Company  SEC Documents complied in all material respects with the requirements of the 1933 Act and  the 1934 Act, and the rules and regulations of the SEC promulgated thereunder applicable to  such Company SEC Documents, and no Company SEC Documents when filed, declared  effective or mailed, as applicable, contained any untrue statement of a material fact or  omitted to state a material fact required to be stated therein or necessary in order to make the  statements therein, in light of the circumstances under which they were made, not misleading.  (b) Since January 1, 2022, the Company has filed all notices and  documents required to be filed by it under the Nasdaq listing rules. Each such notice or  document was filed within the applicable timeframe prescribed by the Nasdaq listing rules.  As of their respective dates, each such notice or document complied in all material respects  with the applicable requirements of the Nasdaq listing rules.  (c) As of the date of this Agreement, there are no outstanding or  unresolved comments in comment letters received from the SEC or its staff.  (d) The financial statements of the Company for the fiscal year ended  December 31, 2021 (included in the Company’s Annual Report on Form 10-K filed with the  SEC on March 17, 2022) present fairly the financial position of the Company and its  consolidated subsidiaries as of the dates indicated and the results of their operations and the  changes in their cash flows for the periods specified; such financial statements have been  prepared in conformity with GAAP, applied on a consistent basis throughout the periods  covered thereby, except as otherwise disclosed therein and, in the case of unaudited, interim  financial statements, subject to normal year-end audit adjustments and the exclusion of  certain footnotes, and any supporting schedules included in the SEC Documents present  fairly the information required to be stated therein.  (e) As of the date hereof, the Common Stock of the Company is admitted  to trading on Nasdaq.  The Company has taken no action designed to, or which is likely to  have the effect of, terminating the registration of the Common Stock under the 1934 Act or  delisting the Common Stock from Nasdaq.  The Company has not received any notification  that the SEC or Nasdaq, as applicable, is contemplating terminating such registration or  listing.  (f) The Company and its subsidiaries have established systems of  “internal control over financial reporting” (as defined in Rule 13a-15(f) of the 1934 Act) that  have been designed by, or under the supervision of, their respective principal executive and  principal financial officers, or persons performing similar functions, to provide reasonable  assurance regarding the reliability of financial reporting and the preparation of financial  

 

  10  4891-4787-1298.2  statements for external purposes in accordance with GAAP, including, but not limited to,  internal accounting controls sufficient to provide reasonable assurance that (i) transactions  are executed in accordance with management’s general or specific authorizations; (ii)  transactions are recorded as necessary to permit preparation of financial statements in  conformity with GAAP and to maintain asset accountability; (iii) access to assets is permitted  only in accordance with management’s general or specific authorization; and (iv) the  recorded accountability for assets is compared with the existing assets at reasonable intervals  and appropriate action is taken with respect to any differences.  (g) There is and has been no material failure on the part of the Company  or any of the Company’s directors or officers, in their capacities as such, to comply with any  applicable provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations  promulgated in connection therewith (the “Sarbanes-Oxley Act”), including Section 402  related to loans and Sections 302 and 906 related to certifications.  4.11. Interim Financials.  The published interim results of the Company  and its consolidated subsidiaries for the nine months ended September 30, 2022, as published  in the Company’s Quarterly Report on Form 10-Q filed with the SEC on November 11, 2022,   have been prepared with all due care and attention (having regard to the fact that the results  were made publicly available) and on accounting bases and assumptions consistent with those  adopted in the preparation of the audited financial statements of the Company and its  consolidated subsidiaries for the fiscal year period ended December 31, 2021, except as  otherwise disclosed therein.  4.12. Absence of Certain Changes.  Since the financial statements of the  Company for the nine-month period ended September 30, 2022 (included in the Company’s  Quarterly Report on Form 10-Q filed with the SEC on November 11, 2021) were prepared:  other than as publicly disclosed in filings with the SEC, the businesses of the Company and  its consolidated subsidiaries have been carried on in the ordinary and usual course; there has  been no significant adverse change in the financial or trading position of the Company taken  as a whole or, to the best of the Company’s knowledge, information and belief, prospects of  the Company other than information otherwise publicly disclosed; the Company has not  acquired or disposed of or agreed pursuant to a binding agreement to acquire or dispose of  any of its assets or businesses other than in the ordinary course of business; the Company has  not entered into any contract or commitment of an unusual, long-term and/or onerous nature  or assumed any material liabilities (including contingent liabilities) (other than as  contemplated by this Agreement); the Company has not paid or made any payment or transfer  to shareholders of any dividend, bonus, loan or distribution other than to the directors of the  Company in their capacity as such directors in a manner consistent with the compensation of  such directors as disclosed in the SEC Documents; and the Company has complied in all  material respects with all the listing requirements of Nasdaq applicable to the Company  (including the disclosure and notification requirements) and any requests for disclosure made  by Nasdaq.  4.13. Tax.  All returns of each member of the Group for taxation purposes  have been made for all periods up to and including December 31, 2021, and all such returns  are correct, and are not the subject of any dispute with or claim by HM Revenue & Customs,  the Internal Revenue Commission, or other relevant taxation authority (other than routine  audits) which would be material to the Company are not likely to result in any such dispute or  claim.  

 

  11  4891-4787-1298.2  4.14. Environmental.  So far as the Company is aware, none of the  Company nor any member of the Group has any material obligation or liability with respect  to pollution, hazardous substances or environmental matters and there are no circumstances  which the Company considers are likely to give rise to the same.  4.15. Insurance.  The Company and each member of the Group maintain  such insurance coverage against fire and other risks upon all their assets and such public and  employers’ liability as the directors of each such company consider appropriate, taking into  account the nature and scale of their activities, the provisions of agreements binding upon it,  such insurance is now in force. The Company is not aware of any fact or matter which would  lead to any such insurance being vitiated or repudiated, there is no material claim pending or  outstanding and all premiums in respect of such insurances are duly paid.  4.16. Intellectual Property.  (a) Each member of the Group has (i) acted reasonably in seeking  professional advice with regard to filing patent applications in respect of material new  inventions; (ii) adopted commercially reasonable and prudent practices with regard to the  protection, prosecution and maintenance of its portfolio of patents, patent applications and  trademarks and other material intellectual property and the payment of renewal fees in  respect thereof; (ii) adopted commercially reasonable and prudent practices to capture  intellectual property rights in respect of material new inventions; and (iv) used commercially  reasonable practices to protect the confidentiality of all material non-patented know how.   None of the intellectual property relating to the business of any member of the Group is the  subject of any claim, opposition, assertion, infringement, attack, right, action or other  restriction or arrangement of whatsoever nature which does or may impinge upon the  validity, enforceability or ownership of the same or the utilization thereof by any member of  the Group to an extent which is material in the context of the Group.  So far as the Company  is aware, and not having obtained freedom to operate opinions in respect of all of its  intellectual property rights, none of the activities of any member of the Group infringes in  any material respect any right of any other person relating to intellectual property or gives  rise to a material liability for any royalty or similar payment.  (b) The intellectual property used or enjoyed by each member of the  Group in connection with its business at the date of this Agreement, and which is material to  such business, is either legally and beneficially owned by that member of the Group, or  licensed to, or used under the authority of the owner by, that member of the Group and are  not subject to any mortgage, charge, lien or other security interest in favor of any third party  save as registered with the United States Patent and Trademark Office or the Registrar of  Companies in the United Kingdom.  4.17. Offering.  Subject to the accuracy of the Investor’s representations set  forth in Section 5, the offer, sale and issuance of each Note to be issued in conformity with  the terms of this Agreement, constitute transactions which are exempt from the registration  requirements of the 1933 Act and from all applicable state registration or qualification  requirements.    4.18. No Integration.  The Company has not, directly or through any agent,  sold, offered for sale, solicited offers to buy or otherwise negotiated in respect of, any  security (as defined in the 1933 Act), that is or will be integrated with the sale of the Note  thereunder in a manner that would require registration of such securities under the 1933 Act.  

 

  12  4891-4787-1298.2  4.19. Brokers’ or Finders’ Fees.  Neither the Company nor any of its  subsidiaries is a party to any contract, agreement or understanding with any person that  would give rise to a valid claim against the Company or any of its subsidiaries for a  brokerage commission, finder’s fee or like payment in connection with the transactions  contemplated by this Agreement.  4.20. No General Solicitation.  Neither the Company nor any person acting  on behalf of the Company has offered or sold any of the securities to be issued pursuant to  this Agreement by any form of general solicitation or general advertising.  The Company has  offered the Notes for sale only to the Investors.  4.21. Foreign Corrupt Practices.  None of the Company, any of its  subsidiaries, nor to the knowledge of the Company, any agent or other person acting on  behalf of the Company or any of its subsidiaries, has: (i) directly or indirectly, used any funds  for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign  or domestic political activity, (ii) made any unlawful payment to foreign or domestic  government officials or employees or to any foreign or domestic political parties or  campaigns from corporate funds, (iii) failed to disclose fully any contribution made by the  Company or any of its subsidiaries (or made by any person acting on its or their behalf of  which the Company is aware) which is in violation of law or (iv) violated in any material  respect any provision of the Foreign Corrupt Practices Act of 1977, as amended, or any  applicable non-U.S. anti-bribery Law.  4.22. Regulation M Compliance.  The Company has not taken, directly or  indirectly, any action designed to or that would reasonably be expected to cause or result in  stabilization or manipulation of any of its securities to facilitate the sale or resale of the  Notes.  4.23. Investment Company.  The Company is not required to be registered  as, and is not an Affiliate of, and immediately following the Closing will not be required to  register as, an “investment company” within the meaning of the Investment Company Act of  1940, as amended.   4.24. Disclosures.  The SEC Documents, when considered together, do not  contain any untrue statement of a material fact or omit to state a material fact necessary in  order to make the statements contained therein, in light of the circumstances under which  they were made, not misleading, other than with respect to the transactions contemplated by  this Agreement and except as will be disclosed pursuant to Section 10.7.  5. Representations and Warranties of the Investor.  Each Investor hereby  represents and warrants to the Company, only as to such Investor and not as to any other  Investor, that:   5.1. Authority.  The Investor is an individual with power and authority to  enter into and consummate the transactions contemplated by this Agreement and to carry out  its obligations thereunder, and to invest in the Note pursuant to this Agreement.  5.2. Authorization.  This Agreement has been duly executed and delivered  by the Investor, and this Agreement constitutes a valid and legally binding obligation of the  Investor, enforceable against the Investor in accordance with its terms, except as  enforceability may be limited by the Enforceability Exceptions.  

 

  13  4891-4787-1298.2  5.3. No Conflicts.  The execution, delivery and performance of this  Agreement and the consummation of the transactions contemplated by this Agreement and  the other Transaction Documents will not (i) conflict with or result in a breach or violation of  any of the terms or provisions of, or constitute a default under, or result in the creation or  imposition of any lien, charge or encumbrance upon any property or assets of the Investor  pursuant to, any indenture, mortgage, deed of trust, loan agreement or other agreement or  instrument to which the Investor is a party or by which the Investor is bound or to which any  of the property or assets of the Investor is subject, or (ii) result in the violation of any law or  statute or any judgment, order, rule  or regulation of any court or arbitrator or governmental  or regulatory authority having jurisdiction over the Investor except, in the case of clauses (i)  and (ii) above, for any such conflict, breach, violation or default that would not, individually  or in the aggregate, have a material adverse effect on the Investor’s ability to perform its  obligations or consummate the transactions contemplated by this Agreement.  5.4. Purchase Entirely for Own Account.  The Notes to be purchased by  the Investor hereunder will be acquired for the Investor’s own account, not as nominee or  agent, and not with a view to the resale or distribution of any part thereof in violation of the  1933 Act, and the Investor has no present intention of selling, granting any participation in, or  otherwise distributing the same in violation of the 1933 Act, without prejudice, however, to  such Investor’s right at all times to sell or otherwise dispose of all or any part of such Notes  in compliance with the terms of such Note and any applicable federal and state securities  laws.  The Investor is not a broker-dealer registered with the SEC under the 1934 Act or an  entity engaged in a business that would require it to be so registered.   5.5. Investment Experience.  The Investor acknowledges that it can bear  the economic risk and complete loss of its investment in the Notes purchased by it and has  such knowledge and experience in financial or business matters that it is capable of  evaluating the merits and risks of the investment contemplated hereby.   5.6. Disclosure of Information.  The Investor has had an opportunity to  receive, review and understand all information related to the Company requested by it and to  ask questions of and receive answers from the Company regarding the Company, its business  and the terms and conditions of the offering of the Notes, and has conducted and completed  its own independent due diligence.  The Investor acknowledges that copies of the SEC  Documents are available on the SEC’s EDGAR system.  Based on such information as the  Investor has deemed appropriate and the representations and warranties of the Company  contained in Section 4 of this Agreement, and without reliance upon any other party  (including, without limitation, the other Investor), it has independently made its own analysis  and decision to enter into this Agreement.  The Investor has sought such accounting, legal  and tax advice as it has considered necessary to make an informed investment decision with  respect to its acquisition of the Notes purchased by it pursuant hereto.  5.7. Restricted Securities.  The Investor understands that the Notes will be  characterized as “restricted securities” under the U.S. federal securities laws inasmuch as they  are being acquired from the Company in a transaction not involving a public offering and that  under such laws and applicable regulations such securities may be resold without registration  under the 1933 Act only in certain limited circumstances. The Investor acknowledges that the  Company has no obligation to register or qualify the Notes for resale. The Investor further  acknowledges that if an exemption from registration or qualification is available, it may be  conditioned on various requirements including, but not limited to, the time and manner of  sale, the holding period for the Notes, and on requirements relating to the Company which  

 

  14  4891-4787-1298.2  are outside of the Investor’s control, and which the Company is under no obligation and may  not be able to satisfy.  5.8. Legends.  It is understood that the Notes bear a restrictive legend in  accordance with the requirements of the Securities Act of 1933 limiting the Investors right to  dispose of the Notes held by it.   5.9. Accredited Investor.  The Investor is an “accredited investor” within  the meaning of Rule 501 under the 1933 Act and has executed and delivered to the Company  a questionnaire in substantially the form attached hereto as Exhibit C (the “Investor  Questionnaire”), which such Investor represents and warrants is true, correct and complete.  The Investor is a sophisticated investor with sufficient knowledge and experience in investing  in private equity transactions to properly evaluate the risks and merits of its purchase of the  Notes which it acquires.  Such Investor has determined based on its own independent review  and such professional advice as it deems appropriate that its purchase of such Notes and  participation in the transactions contemplated by this Agreement (i) are fully consistent with  its financial needs, objectives and condition, (ii) comply and are fully consistent with all  investment policies, guidelines and other restrictions applicable to such Investor, (iii) have  been duly authorized and approved by all necessary action, (iv) do not and will not violate or  constitute a default under any law, rule, regulation, agreement or other obligation by which  such Investor is bound and (v) are a fit, proper and suitable investment for such Investor,  notwithstanding the substantial risks inherent in investing in or holding the Notes.   5.10. No General Solicitation.  The Investor did not learn of the investment  in the Notes as a result of any general solicitation or general advertising.   5.11. Brokers and Finders.  No Person will have, as a result of the  transactions contemplated by this Agreement, any valid right, interest or claim against or  upon the Company or the Investor for any commission, fee or other compensation pursuant to  any agreement, arrangement or understanding entered into by or on behalf of the Investor.   5.12. Short Sales and Confidentiality Prior to the Date Hereof.  Other than  consummating the transactions contemplated hereunder, the Investor has not, nor has any  Person acting on behalf of or pursuant to any understanding with the Investor, directly or  indirectly executed any purchases or sales, including Short Sales, of the securities of the  Company or directly or indirectly engaged in any action designed to, or which might be  reasonably expected to, cause or result in any manipulation of the price of the securities of  the Company during the period commencing as of the time that such Investor was first  contacted by the Company or any other Person regarding the transactions contemplated  hereby and ending immediately prior to the date hereof.  The Investor has maintained the  confidentiality of all disclosures made to it in connection with this transaction (including the  existence and terms of this transaction). Notwithstanding the foregoing, for avoidance of  doubt, nothing contained herein shall constitute a representation or warranty, or preclude any  actions, with respect to the identification of the availability of, or securing of, available  securities to borrow in order to effect Short Sales or similar transactions in the future.  5.13. No Government Recommendation or Approval.  The Investor  understands that no United States federal or state agency, or similar agency of any other  country, has reviewed, approved, passed upon, or made any recommendation or endorsement  of the Company or the purchase of the Note.   

 

  15  4891-4787-1298.2  5.14. No Rule 506 Disqualifying Activities.  The Investor has not taken any  of the actions set forth in, and is not subject to, the disqualification provisions of Rule  506(d)(1) of the 1933 Act.   6. Covenants and Agreements of the Company and the Investors.   6.1. No Conflicting Agreements.  The Company will not take any action,  enter into any agreement or make any commitment that would conflict or interfere in any  material respect with the Company’s obligations to the Investors under this Agreement.  6.2. Removal of Legends.   (a) In connection with any sale, assignment, transfer or other disposition  by an Investor of any Notes held by it (any such Investor, an “Assigning Investor”) pursuant  to Rule 144 or pursuant to any other exemption under the 1933 Act such that the purchaser  acquires freely tradable securities and upon compliance by the Assigning Investor with the  requirements of this Agreement, if requested by the Assigning Investor, the Company shall  use commercially reasonable efforts to remove any restrictive legends that appear on any  such Note and to issue a new, unlegended Note substantially the same as the replaced Note  (other than the inclusion of restrictive legends), provided that the Company has received from  the Assigning Investor customary representations and other documentation reasonably  acceptable to the Company in connection therewith and, if necessary, otherwise sufficient to  support any required legal opinion with respect thereto.    (b) Subject to receipt from an Assigning Investor by the Company of  customary representations and other documentation reasonably acceptable to the Company in  connection therewith and, if necessary, otherwise sufficient to support any required legal  opinion with respect thereto, upon the earliest of such time as any Note purchased by an  Assigning Investor (i) has been sold or transferred pursuant to an effective registration  statement, (ii) has been sold pursuant to Rule 144, or (iii) is eligible for resale under Rule  144(b)(1) or any successor provision (such earliest date, the “Effective Date”), the Company  shall issue a new Note to the acquiror thereof substantially the same as the replaced Note,  other than the inclusion of restrictive legends. The Company agrees that following the  Effective Date or at such time as such legend is no longer required under this Section 6.2, it  will, following the delivery by any Investor to the Company of any Note held by such  Investor issued with a restrictive legend, use commercially reasonable efforts to deliver or  cause to be delivered to such Investor a new Note, substantially the same as the replaced  Note, other than the inclusion of any legends. The Company may not make any notation on  its records that enlarge the restrictions on transfer set forth in this Section 6.2.  (c) Subject to the restrictions on dispositions pursuant to Section 7.1 of  this Agreement, each Investor agrees with the Company that such Investor will sell the Notes  held by it only in compliance with an exemption from the registration requirements of the  1933 Act.  6.3. Subsequent Equity Sales. The Company shall not, and shall use its  commercially reasonable efforts to ensure that no Affiliate of the Company shall, sell, offer  for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in  Section 2 of the 1933 Act) that will be integrated with the offer or sale of the Notes in a  manner that would require the registration under the 1933 Act of the sale of the Notes to the  Investors, or that will be integrated with the offer or sale of the Notes for purposes of the  

 

  16  4891-4787-1298.2  rules and regulations of any trading market such that it would require shareholder approval  prior to the closing of such other transaction unless shareholder approval is obtained before  the closing of such subsequent transaction.   6.4. Short Sales and Confidentiality After the Date Hereof.  Each Investor  covenants that neither it nor any Affiliates acting on its behalf or pursuant to any  understanding with it will execute any Short Sales during the period from the date hereof  until such time as the transactions contemplated by this Agreement are first publicly  announced.  Each Investor covenants that until such time as the transactions contemplated by  this Agreement are publicly disclosed by the Company, such Investor will maintain the  confidentiality of all disclosures made to it in connection with this transaction (including the  existence and terms of this transaction).  Each Investor understands and acknowledges that  the SEC currently takes the position that coverage of Short Sales of securities “against the  box” prior to effectiveness of a resale registration statement with securities included in such  registration statement would be a violation of Section 5 of the 1933 Act, as set forth in Item  239.10 of the Securities Act Rules Compliance and Disclosure Interpretations compiled by  the Office of Chief Counsel, Division of Corporation Finance.  7. Acknowledgements.   7.1. Insider Trading. In addition to the restrictions in this Agreement on  the Disposition of Common Stock and Common Stock Equivalents of the Company, the  Investor hereby acknowledges that it is aware that United States securities Laws prohibit any  person who has material, non-public information about a company obtained directly or  indirectly from that company from purchasing or selling securities of such company or from  communicating such information to any other person, including under circumstances in  which it is reasonably foreseeable that such person is likely to purchase or sell such  securities.  8. Survival.  The representations, warranties, covenants and agreements  contained in this Agreement shall survive the Closing of the transactions contemplated by  this Agreement for the applicable statute of limitations.    9. Events of Default.   9.1. Defaults. The following are events of default under this Agreement  (each, an “Event of Default”): (a) the Company fails to pay any principal, interest, fees,  charges, or any other amount when due and payable hereunder or under any Note; (b) a  receiver, trustee or other similar official shall be appointed over the Company or a material  part of its assets and such appointment shall remain uncontested for twenty (20) calendar  days or shall not be dismissed or discharged within sixty (60) calendar days; (c) the Company  generally fails to pay, or admits in writing its inability to pay, its debts as they become due,  subject to applicable grace periods, if any; (d) the Company makes a general assignment for  the benefit of creditors; (e) the Company files a petition for relief under any bankruptcy,  insolvency or similar law (domestic or foreign); (f) an involuntary bankruptcy proceeding is  commenced or filed against the Company; (g) the Company or any pledgor, trustor, or  guarantor of the obligations evidenced by the Notes defaults or otherwise fails to observe or  perform any covenant, obligation, condition or agreement of the Company or such pledgor,  trustor, or guarantor contained herein or in any other Transaction Document; (h) any  representation, warranty or other statement made or furnished by or on behalf of the  Company to any Investor herein, in any Transaction Document, or otherwise in connection  

 

  17  4891-4787-1298.2  with the issuance of the Notes is false, incorrect, incomplete or misleading in any material  respect when made or furnished; (i) any money judgment, writ or similar process is entered or  filed against the Company or any subsidiary of the Company or any of its property or other  assets for more than $500,000.00, and shall remain unvacated, unbonded or unstayed for a  period of twenty (20) calendar days unless otherwise consented to by the Majority Investors;  (j) the Company fails, in any material respect, to observe or perform any covenant set forth in  the Transaction Documents; or (k) the Company, or any Affiliate of the Company, breaches,  in any material respect, any covenant or other term or condition contained in any Other  Agreements. Notwithstanding the foregoing, the occurrence of any event specified in Section  9.1(h) – (k) shall not be considered an Event of Default hereunder if such event is reasonably  deemed capable of being cured by the Majority Investors and is so cured, to the satisfaction  of the Majority Investors, within forty-five (45) days of the occurrence of such event.  9.2. Remedies. At any time and from time to time after any Investor  becomes aware of the occurrence of any Event of Default that is continuing, the Majority  Investors may accelerate the Notes by written notice to the Company, with all outstanding  amounts evidenced by the Notes being immediately due and payable in cash.  Notwithstanding the foregoing, upon the occurrence of any Event of Default described in  clauses (b), (c), (d), (e), or (f) of Section 9.1, then all such outstanding amounts as of the date  of acceleration shall become immediately and automatically due and payable in cash, without  any written notice required by the Investors. At any time following the occurrence of any  Event of Default, upon written notice given by or on behalf of the Majority Investors to the  Company, interest shall accrue on the outstanding principal amount of the Notes beginning  on the date the applicable Event of Default occurred at an interest rate equal to the Interest  Rate plus 2% per annum (“Default Interest”). In connection with acceleration described  herein, the Investors need not provide, and the Company hereby waives, any presentment,  demand, protest or other notice of any kind, and each Investor may immediately and without  expiration of any grace period enforce any and all of its rights and remedies hereunder, under  the other Transaction Documents, and all other remedies available to it under applicable law.  Such acceleration may be rescinded and annulled by the unanimous vote of all Investors at  any time prior to payment hereunder and each Investor shall have all rights as a holder of  Notes until such time, if any, as each Investor receives full payment pursuant to this Section  9.2. No such rescission or annulment shall affect any subsequent Event of Default or impair  any right consequent thereon. Nothing herein shall limit any Investor’s right to pursue in one  or more arbitrations any other remedies available to it at law or in equity including, without  limitation, a decree of specific performance and/or injunctive relief.  10. Miscellaneous.   10.1. Successors and Assigns.  This Agreement may not be assigned by a  party hereto without the prior written consent of the Company or the Investors, as applicable;  provided, however, that an Investor may offer, sell, assign or transfer any of its interest in this  Agreement, any Note or other Transaction Document without the consent of Borrower.  The  provisions of this Agreement shall inure to the benefit of and be binding upon the respective  permitted successors and assigns of the parties.    10.2. Counterparts; Electronic Execution.  This Agreement may be  executed in any number of counterparts, each of which shall be an original but all of which  together shall constitute one instrument.  Each counterpart may consist of a number of copies  hereof, each signed by less than all, but together signed by all, of the parties hereto.  The  parties agree to electronic contracting and signatures with respect to the Transaction  

 

  18  4891-4787-1298.2  Documents (other than the Notes).  Delivery of an electronic signature to, or a signed copy  of, this Agreement and such other Transaction Documents (other than the Notes) by  facsimile, email or other electronic transmission shall be fully binding on the parties to the  same extent as the delivery of the signed originals and shall be admissible into evidence for  all purposes.  The words “execution,” “execute”, “signed,” “signature,” and words of like  import in or related to any document to be signed in connection with this Agreement and the  other Transaction Documents (other than the Notes) shall be deemed to include electronic  signatures, the electronic matching of assignment terms and contract formations on electronic  platforms approved by the Company, or the keeping of records in electronic form, each of  which shall be of the same legal effect, validity or enforceability as a manually executed  signature or the use of a paper-based recordkeeping system, as the case may be, to the extent  and as provided for in any applicable law, including the Federal Electronic Signatures in  Global and National Commerce Act, the New York State Electronic Signatures and Records  Act, or any other similar state laws based on the Uniform Electronic Transactions Act.   Notwithstanding the foregoing, if any Investor shall request manually signed counterpart  signatures to any Transaction Document, the Company hereby agrees to use its reasonable  endeavors to provide such manually signed signature pages as soon as reasonably practicable  (but in any event within 30 days of such request or such longer period as the requesting  Investor and the Company may mutually agree).   10.3. Titles and Subtitles.  The titles and subtitles used in this Agreement  are used for convenience only and are not to be considered in construing or interpreting this  Agreement.   10.4. Notices.  Unless otherwise provided, any notice required or permitted  under this Agreement shall be given in writing and shall be deemed effectively given as  hereinafter described (i) if given by personal delivery, then such notice shall be deemed given  upon such delivery, (ii) if given by electronic mail, then such notice shall be deemed given  upon receipt of confirmation of complete transmittal, and (iii) if given by an internationally  recognized overnight air courier, then such notice shall be deemed given one Business Day  after delivery to such carrier.  All notices shall be addressed to the party to be notified at the  address as follows, or at such other address as such party may designate by ten days’ advance  written notice to the other party:   If to the Company:   Summit Therapeutics Inc.  2882 Sand Hill Road  Suite 106  Menlo Park, CA  94025  Attention: Finance  Email: finance@summitplc.com    With a copy to:     Baker & Hostetler LLP  45 Rockefeller Plaza  New York, New York 10111  Attention: Adam W. Finerman   Email: AFinerman@bakerlaw.com     

 

  19  4891-4787-1298.2  If to an Investor:   to the address for such Investor set forth on Exhibit A hereto.   10.5. Expenses.  The parties hereto shall pay their own costs and expenses  in connection herewith regardless of whether the transactions contemplated hereby are  consummated; it being understood that each of the Company and each Investor has relied on  the advice of its own respective counsel and/or other professional advisers.   10.6. No Rule of Strict Construction. Each party and its counsel has  reviewed and jointly participated in the establishment of this Agreement, the Notes and the  other Transaction Documents. No rule of strict construction or presumption that ambiguities  will be construed against any drafter will apply, and no presumptions will be made or  inferences drawn because of the final inclusion of a term not contained in a prior draft or the  final deletion of a term contained in a prior draft.     10.7. Publicity.  Except as set forth below, no public release or  announcement concerning the transactions contemplated hereby shall be issued by the  Investor without the prior consent of the Company (which consent shall not be unreasonably  withheld), except as such release or announcement may be required by law or the applicable  rules or regulations of any securities exchange or securities market, in which case the  Investor shall allow the Company, to the extent reasonably practicable in the circumstances,  reasonable time to comment on such release or announcement in advance of such issuance.   The Company shall not include the name of the Investor in any press release or public  announcement (which, for the avoidance of doubt, shall not include any filing with the SEC)  without the prior written consent of the Investor, except as otherwise required by law or the  applicable rules or regulations of any securities exchange or securities market, in which case  the Company shall allow the Investor, to the extent reasonably practicable in the  circumstances, reasonable time to comment on such release or announcement in advance of  such issuance.  Promptly following the date this Agreement is executed, the Company may  issue a press release disclosing all material terms of transactions contemplated by this  Agreement (the “Press Release”) and make an announcement thereof (including the name of  the Investor) to a Regulatory Investment Service.  No later than 5:30 p.m. (New York City  time) on the fourth Business Day following the date this Agreement is executed, the  Company will file a Report on Form 8-K (the “8-K Filing”) attaching the press release, if  applicable, described in the foregoing sentence as well as a copy of this Agreement.  The  parties acknowledge that the Company shall file this Agreement with the SEC where it will  be publicly available.  In addition, the Company will make such other filings and notices in  the manner and time required by the SEC or Nasdaq.  The parties acknowledge that from and  after the issuance of the Press Release and/or Form 8-K, the Investor shall not be in  possession of any material, nonpublic information received from the Company or any of its  respective officers, directors, employees or agents, with respect to the transactions  contemplated hereby that is not disclosed in the Press Release.  10.8. Severability.  Any provision of this Agreement that is prohibited or  unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of  such prohibition or unenforceability without invalidating the remaining provisions hereof but  shall be interpreted as if it were written so as to be enforceable to the maximum extent  permitted by applicable law, and any such prohibition or unenforceability in any jurisdiction  shall not invalidate or render unenforceable such provision in any other jurisdiction.  To the  

 

  20  4891-4787-1298.2  extent permitted by applicable law, the parties hereby waive any provision of law which  renders any provision hereof prohibited or unenforceable in any respect.   10.9. Entire Agreement.  This Agreement, including the signature pages  and Exhibits hereto, constitutes the entire agreement among the parties hereof with respect to  the subject matter hereof and thereof and supersedes all prior agreements and understandings,  both oral and written, between the parties with respect to the subject matter hereof and  thereof.   10.10. Further Assurances.  The parties shall execute and deliver all such  further instruments and documents and take all such other actions as may reasonably be  required to carry out the transactions contemplated hereby and to evidence the fulfillment of  the agreements herein contained.   10.11. Governing Law; Consent to Jurisdiction; Waiver of Jury Trial.  This  Agreement shall be governed by, and construed in accordance with, the internal laws of the  State of New York without regard to the choice of law principles thereof.  Each of the parties  hereto irrevocably submits to the exclusive jurisdiction of the courts of the State of New York  located in New York County and the United States District Court for the Southern District of  New York for the purpose of any suit, action, proceeding or judgment relating to or arising  out of this Agreement and the transactions contemplated hereby.  Service of process in  connection with any such suit, action or proceeding may be served on each party hereto  anywhere in the world by the same methods as are specified for the giving of notices under  this Agreement.  Each of the parties hereto irrevocably consents to the jurisdiction of any  such court in any such suit, action or proceeding and to the laying of venue in such court.   Each party hereto irrevocably waives any objection to the laying of venue of any such suit,  action or proceeding brought in such courts and irrevocably waives any claim that any such  suit, action or proceeding brought in any such court has been brought in an inconvenient  forum.  EACH OF THE PARTIES HERETO WAIVES ANY RIGHT TO REQUEST A  TRIAL BY JURY IN ANY LITIGATION WITH RESPECT TO THIS AGREEMENT  AND REPRESENTS THAT COUNSEL HAS BEEN CONSULTED SPECIFICALLY  AS TO THIS WAIVER.   11. Amendments and Waivers.   11.1. Requirements. This Agreement and the Notes may be amended, and  the observance of any term hereof or of the Notes may be waived (either retroactively or  prospectively), only with the written consent of the Company and the Majority Investors,  except that:  (a) no amendment or waiver of any of Sections 2, 3, 4, 5, and 6 hereof or  any defined term (as it is used therein), will be effective as to any Investor unless consented  to by such Investor in writing; and  (b) no amendment or waiver may, without the written consent of each  Investor then holding a Note, (i) change this Section 11 (or any defined term used in this  Section), the amount or time of any prepayment or payment of principal of, or reduce the rate  or change the time of payment or method of computation of interest on the Notes, (ii) change  the percentage of the principal amount of the Notes the holders of which are required to  consent to any amendment or waiver, (iii) amend or waive any provision of Section 9 (or any  

 

  21  4891-4787-1298.2  defined term used in such Section) or any Event of Default, or (iv) amend or waive any terms  of the Notes or the form of Note attached to this Agreement.  11.2. Solicitation of Holders of Notes.  (a) The Company will provide each Investor with sufficient information,  sufficiently far in advance of the date a decision is required, to enable such Investor to make  an informed and considered decision with respect to any proposed amendment, waiver or  consent in respect of any of the provisions hereof or of the Notes or any other Transaction  Document.  The Company will deliver executed or true and correct copies of each  amendment, waiver or consent effected pursuant to this Section 11 to each Investor promptly  following the date on which it is executed and delivered by, or receives the consent or  approval of, the requisite Investors.  (b) The Company will not directly or indirectly pay or cause to be paid  any remuneration, whether by way of supplemental or additional interest, fee or otherwise, or  grant any security or provide other credit support, to any Investor as consideration for or as  an inducement to the entering into by such holder of any waiver or amendment of any of the  terms and provisions hereof or of any other Transaction Document unless such remuneration  is concurrently paid, or security is concurrently granted or other credit support concurrently  provided, on the same terms, ratably to each Investor even if such Investor did not consent to  such waiver or amendment.  (c) Any consent given pursuant to this Section 11 by an Investor that has  transferred or has agreed to transfer its Note to (i) the Company, (ii) any subsidiary or any  other Affiliate of the Company or (iii) any other Person in connection with, or in anticipation  of, such other Person acquiring, making a tender offer for or merging with the Company  and/or any of its Affiliates or subsidiaries, in each case in connection with such consent, shall  be void and of no force or effect except solely as to such holder, and any amendments  effected or waivers granted or to be effected or granted that would not have been or would  not be so effected or granted but for such consent (and the consents of all other holders of  Notes that were acquired under the same or similar conditions) shall be void and of no force  or effect except solely as to such holder.  11.3. Binding Effect, Etc. Any amendment or waiver consented to as  provided in this Section 11 applies equally to all holders of Notes and is binding upon them  and upon each future holder of any Note and upon the Company without regard to whether  such Note has been marked to indicate such amendment or waiver.  No such amendment or  waiver will extend to or affect any obligation, covenant, agreement, or Event of Default not  expressly amended or waived or impair any right consequent thereon.  No course of dealing  between the Company and any holder of a Note and no delay in exercising any rights  hereunder or under any Note or other Transaction Document shall operate as a waiver of any  rights of any holder of such Note.  [remainder of page intentionally left blank]  

 

  4891-4787-1298.2    IN WITNESS WHEREOF, the parties have executed this Agreement or caused their duly  authorized officers to execute this Agreement as of the date first above written.     COMPANY: SUMMIT THERAPEUTICS INC.     By: /s/ Ankur Dhingra    Name: Ankur Dhingra     Title:  Chief Financial Officer       

 

  4891-4787-1298.2      INVESTORS: Investor A         By: /s/ Robert Duggan    Name: Robert Duggan       Investor B       By: /s/ Mahkam Zanganeh    Name: Mahkam Zanganeh    

 

  4891-4787-1298.2  EXHIBIT A – page 1 of 2  Investors    Investor A    [Personal information omitted.]    Investor Information   Name:    Robert W. Duggan  Contact Person:      Address:       City:      State:      Zip Code:      Telephone:      Facsimile:      Email:      Name in which Note shall be recorded:               

 

  4891-4787-1298.2  Exhibit A – page 2 of 2  Investor B  [Personal information omitted.]      Investor Information   Name:    Mahkam Zanganeh  Contact Person:      Address:       City:      State:      Zip Code:      Telephone:      Facsimile:      Email:      Name in which Note shall be recorded:            

 

  4891-4787-1298.2  EXHIBIT B-1    DUGGAN $400 MILLION NOTE       

 

    4888-3067-6802.2  EXHIBIT B-1  THIS NOTE HAS NOT BEEN REGISTERED UNDER THE UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY  STATE SECURITIES LAWS AND MAY NOT BE OFFERED, SOLD, PLEDGED,  ASSIGNED, OR OTHERWISE TRANSFERRED UNLESS (1) A REGISTRATION  STATEMENT WITH RESPECT HERETO IS EFFECTIVE UNDER THE SECURITIES  ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR (2) THE COMPANY  RECEIVES AN OPINION OF COUNSEL TO THE HOLDER OF THIS NOTE, WHICH  COUNSEL AND OPINION ARE REASONABLY SATISFACTORY TO THE  COMPANY, THAT THIS NOTE MAY BE OFFERED, SOLD, PLEDGED, ASSIGNED,  OR OTHERWISE TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT  AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR  APPLICABLE STATE SECURITIES LAWS.  PROMISSORY NOTE  Effective Date: December 6, 2022 U.S. $400,000,000  FOR VALUE RECEIVED, Summit Therapeutics Inc., a Delaware corporation  (“Borrower”), promises to pay to Robert Duggan or his successors or assigns (“Lender”), Four  Hundred Million Dollars (the “Principal Amount”) and any interest, fees, charges, and late fees  on February 15, 2023 (the “Maturity Date”), subject to and in accordance with the terms set  forth herein, and to pay interest on the Outstanding Balance (as defined below) at the rate equal  to the Interest Rate (as defined below) per annum (subject to Section 2.2) from the Effective  Date until the Outstanding Balance is paid in full. This Promissory Note (this “Note”) is issued  and made effective as of December 6, 2022 (the “Effective Date”). This Note is issued pursuant  to, and subject to the terms of, that certain Note Purchase Agreement dated December 6, 2022, as  the same may be amended, restated, supplemented, modified or replaced from time to time, by  and between Borrower and Lender and the other lenders party thereto from time to time (the  “Purchase Agreement”). All interest calculations hereunder shall be computed on the basis of a  360-day year comprised of twelve (12) thirty (30) day months, and shall be payable in  accordance with the terms of this Note.   1. Payment.  1.1 Payment of Interest. Subject to Section 2.1, from and including the date  hereof to, but excluding, the Maturity Date, interest on this Note shall accrue on the Outstanding  Balance of this Note outstanding from time to time at a rate of interest per annum (the “Interest  Rate”) equal to 7.50%.  All interest shall be paid by the Company to the Lender on the Effective  Date for the period through the Maturity Date (the “Prepaid Interest”).  Default Interest shall be  paid as provided for in the Purchase Agreement (but only the difference between the total  Default Interest amount and the Prepaid Interest shall be payable). The Borrower acknowledges  and agrees that the Prepaid Interest constitutes compensation to Lender for arranging and  providing the financing to the Borrower under this Note and the other Transaction Documents  and shall, therefore, be deemed fully earned on the date hereof, and not subject to any refund or  reimbursement for any reason. Prepaid Interest shall be paid in cash or in shares of the  

 

  2  4888-3067-6802.2  Company’s common stock, par value $.01 per share (“Shares”), as may be determined by the  Lender on the date hereof. In the event the Lender elects to receive Prepaid Interest in Shares, the  number of Shares shall equal the dollar amount of Prepaid Interest, divided by the consolidated  closing bid price immediately preceding the time the Company enters into the Purchase  Agreement, plus $.01.  The issuance of Shares shall be subject to compliance with securities laws  and Nasdaq rules and regulations. For all periods following the Maturity Date, interest shall  accrue on the Outstanding Balance at the prime rate announced to be then in effect as published  as the average rate in the Wall Street Journal (Northeast Edition) (the “Prime Rate”) plus 50  basis points, for three months immediately following the Maturity Date, and thereafter shall  accrue at the Prime Rate plus 300 basis points, to be determined on the first day of each calendar  month for the succeeding calendar month. All accrued and unpaid interest shall be payable on the  Maturity Date or Extended Maturity Date (as defined below), as the case may be, or if such day  is not a Business Day, on the immediately succeeding Business Day (the “Interest Payment  Date”).  Interest shall be calculated on the basis of a 360-day year and actual days elapsed.  1.2 Payment of Principal and Interest. On the Maturity Date, the Outstanding  Balance, including all principal under this Note, together with all accrued and unpaid interest  thereon and all other sums evidenced by this Note, shall be due and payable in cash, subject to  the next sentence.  At the Company’s election, the term of this Note can be extended one or more  times by notice to the Lender sent at least three (3) business days prior the Maturity Date, or  extended Maturity Date, as the case may be, but in no event to a date later than September 6,  2024 (such extended Maturity Date, as may be extended from time to time, the “Extended  Maturity Date”).  Upon payment in full of the Outstanding Balance of this Note and all accrued  and unpaid interest thereon, this Note will be automatically cancelled, whether or not this Note  has been surrendered. Should the Company elect to extend the term of this Note, following the  Maturity Date, interest shall be paid in cash quarterly in arrears, on each of March 31, June 30,  September 30 and December 31.  As used herein, “Outstanding Balance” means as of any date of determination, the  outstanding principal amount of this Note, as reduced or increased, as the case may be, pursuant  to the terms hereof for payment, offset, or otherwise, plus accrued but unpaid interest, collection  and enforcements costs (including attorneys’ fees) incurred by Lender, transfer, stamp, issuance  and similar taxes and any other fees or charges incurred under this Note.  2. Defaults and Remedies.  2.1 Defaults. As used herein, the term “Event of Default” has the meaning  given such term in the Purchase Agreement.   2.2 Remedies. At any time and from time to time after Lender becomes aware  of the occurrence of any Event of Default that is continuing, Lender may exercise all of its rights  and remedies provided for in the Purchase Agreement or otherwise available under applicable  law or equity, including, subject to the Purchase Agreement, the right to accelerate this Note by  written notice to Borrower, with the Outstanding Balance becoming immediately due and  payable in cash. Notwithstanding the foregoing, upon the occurrence of any Event of Default  described in clauses (b), (c), (d), (e), or (f) of Section 9.1 of the Purchase Agreement, the  Outstanding Balance as of the date of acceleration shall become immediately and automatically  

 

  3  4888-3067-6802.2  due and payable in cash, without any written notice required by Lender or any other person.  Upon the occurrence of an Event of Default, interest shall accrue on the Outstanding Balance at  an interest rate equal to the Default Interest (as defined in the Purchase Agreement) rate. In  connection with acceleration described herein, Lender need not provide, and Borrower hereby  waives, any presentment, demand, protest or other notice of any kind, and Lender may  immediately and without expiration of any grace period enforce any and all of its rights and  remedies hereunder and all other remedies available to it under applicable law. Such acceleration  may be rescinded and annulled by Lender in accordance with the Purchase Agreement at any  time prior to payment hereunder and Lender shall have all rights as a holder of the Note until  such time, if any, as Lender receives full payment pursuant to this Section 2.2. No such  rescission or annulment shall affect any subsequent Event of Default or impair any right  consequent thereon. Nothing herein shall limit Lender’s right to pursue in one or more  arbitrations any other remedies available to it at law or in equity including, without limitation, a  decree of specific performance and/or injunctive relief. In the event the Lender accelerates, and  receives any payment (including any payment in full) of the Outstanding Balance and other  monetary obligations of the Borrower under the Transaction Documents, the Borrower shall not  be entitled to any refund of the Prepaid Interest.  3. Unconditional Obligation; No Offset. Borrower acknowledges that this Note is an  unconditional, valid, binding and enforceable obligation of Borrower not subject to offset,  deduction or counterclaim of any kind. Borrower hereby waives any rights of offset it now has or  may have hereafter against Lender, its successors and assigns, and agrees to make the payments  called for herein in accordance with the terms of this Note.  4. Waiver. No waiver of any provision of this Note shall be effective unless it is in  the form of a writing signed by the party granting the waiver. No waiver of any provision or  consent to any prohibited action shall constitute a waiver of any other provision or consent to any  other prohibited action, whether or not similar. No waiver or consent shall constitute a  continuing waiver or consent or commit a party to provide a waiver or consent in the future  except to the extent specifically set forth in writing.  5. Borrower Prepayment. Borrower shall have the right, exercisable at any time in its  sole and absolute discretion without penalty or fee, to prepay any amount of this Note (such  amount, the “Prepayment Amount”) by providing written notice to Lender at least two (2)  business days in advance of such prepayment (each, a “Prepayment Notice”). On the  prepayment date Borrower shall pay the Prepayment Amount in cash to Lender. Upon any  prepayment, there shall be no refund of any Prepaid Interest.  6. Payment of Collection Costs. If this Note is placed in the hands of an attorney for  collection or enforcement prior to commencing arbitration or legal proceedings, or is collected or  enforced through any arbitration or legal proceeding, or Lender otherwise takes action to collect  amounts due under this Note or to enforce the provisions of this Note, then Borrower shall pay  the costs incurred by Lender for such collection, enforcement or action including, without  limitation, attorneys’ fees and disbursements.  

 

  4  4888-3067-6802.2  7. Opinion of Counsel. In the event that an opinion of counsel is needed for any  matter related to this Note, Lender has the right to have any such opinion provided by its  counsel; provided that such opinion shall be reasonably acceptable to Borrower.  8. Governing Law; Venue. This Note shall be construed and enforced in accordance  with, and all questions concerning the construction, validity, interpretation and performance of  this Note shall be governed by, the internal laws of the State of New York, without giving effect  to any choice of law or conflict of law provision or rule (whether of the State of New York or  any other jurisdiction) that would cause the application of the laws of any jurisdiction other than  the State of New York. The provisions set forth in the Purchase Agreement to determine the  proper venue for any disputes are incorporated herein by this reference.  9. Cancellation. After repayment of the entire Outstanding Balance, this Note shall  be deemed paid in full, shall automatically be deemed canceled, and shall not be reissued.  10. Amendments. The prior written consent of both parties hereto shall be required  for any change or amendment to this Note.  11. Assignments. Borrower may not assign this Note without the prior written consent  of Lender. This Note may be offered, sold, assigned or transferred by Lender without the consent  of Borrower.  12. Time is of the Essence. Time is expressly made of the essence with respect to  each and every provision of this Note and the documents and instruments entered into in  connection herewith.  13. Notices. Whenever notice is required to be given under this Note, unless  otherwise provided herein, such notice shall be given in accordance with the subsection of the  Purchase Agreement titled “Notices.”  14. Liquidated Damages. Lender and Borrower agree that in the event Borrower fails  to comply with any of the terms or provisions of this Note, Lender’s damages would be uncertain  and difficult (if not impossible) to accurately estimate because of the parties’ inability to predict  future interest rates, future share prices, future trading volumes and other relevant factors.  Accordingly, Lender and Borrower agree that any fees, balance adjustments, Prepaid Interest,  Default Interest or other charges assessed under this Note are not penalties but instead are  intended by the parties to be, and shall be deemed, liquidated damages (under Lender’s and  Borrower’s expectations that any such liquidated damages will, if allowed under applicable law,  tack back to the Effective Date for purposes of determining the holding period under Rule 144).  15. Waiver of Jury Trial. EACH OF LENDER AND BORROWER IRREVOCABLY  WAIVES ANY AND ALL RIGHTS SUCH PARTY MAY HAVE TO DEMAND THAT ANY  ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR IN ANY WAY  RELATED TO THIS NOTE OR THE RELATIONSHIPS OF THE PARTIES HERETO BE  TRIED BY JURY. THIS WAIVER EXTENDS TO ANY AND ALL RIGHTS TO DEMAND A  TRIAL BY JURY ARISING UNDER COMMON LAW OR ANY APPLICABLE STATUTE,  LAW, RULE OR REGULATION. FURTHER, EACH PARTY HERETO ACKNOWLEDGES  

 

  5  4888-3067-6802.2  THAT SUCH PARTY IS KNOWINGLY AND VOLUNTARILY WAIVING SUCH PARTY’S  RIGHT TO DEMAND TRIAL BY JURY.  16. Voluntary Agreement. Borrower has carefully read this Note and has asked any  questions needed for Borrower to understand the terms, consequences and binding effect of this  Note and fully understand them. Borrower has had the opportunity to seek the advice of an  attorney of Borrower’s choosing, or has waived the right to do so, and is executing this Note  voluntarily and without any duress or undue influence by Lender or anyone else.  17. Severability. If any part of this Note is construed to be in violation of any law,  such part shall be modified to achieve the objective of Borrower and Lender to the fullest extent  permitted by law and the balance of this Note shall remain in full force and effect.  [Remainder of page intentionally left blank; signature page follows] 

 

  4888-3067-6802.2  IN WITNESS WHEREOF, Borrower has caused this Note to be duly executed as of the  Effective Date.   BORROWER:      SUMMIT THERAPEUTICS INC.         By:    Name: Ankur Dhingra   Title: Chief Financial Officer    ACKNOWLEDGED, ACCEPTED AND AGREED:  LENDER:      Robert Duggan            

 

  4891-4787-1298.2  EXHIBIT B-2  ZANGANEH $20 MILLION NOTE       

 

    4857-0618-4770.2  EXHIBIT B-2  THIS NOTE HAS NOT BEEN REGISTERED UNDER THE UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY  STATE SECURITIES LAWS AND MAY NOT BE OFFERED, SOLD, PLEDGED,  ASSIGNED, OR OTHERWISE TRANSFERRED UNLESS (1) A REGISTRATION  STATEMENT WITH RESPECT HERETO IS EFFECTIVE UNDER THE SECURITIES  ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR (2) THE COMPANY  RECEIVES AN OPINION OF COUNSEL TO THE HOLDER OF THIS NOTE, WHICH  COUNSEL AND OPINION ARE REASONABLY SATISFACTORY TO THE  COMPANY, THAT THIS NOTE MAY BE OFFERED, SOLD, PLEDGED, ASSIGNED,  OR OTHERWISE TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT  AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR  APPLICABLE STATE SECURITIES LAWS.  PROMISSORY NOTE  Effective Date: December 6, 2022 U.S. $20,000,000  FOR VALUE RECEIVED, Summit Therapeutics Inc., a Delaware corporation  (“Borrower”), promises to pay to Mahkam Zanganeh or her successors or assigns (“Lender”),  Twenty Million Dollars (the “Principal Amount”) and any interest, fees, charges, and late fees  on February 15, 2023 (the “Maturity Date”), subject to and in accordance with the terms set  forth herein, and to pay interest on the Outstanding Balance (as defined below) at the rate equal  to the Interest Rate (as defined below) per annum (subject to Section 2.2) from the Effective  Date until the Outstanding Balance is paid in full. This Promissory Note (this “Note”) is issued  and made effective as of December 6, 2022 (the “Effective Date”). This Note is issued pursuant  to, and subject to the terms of, that certain Note Purchase Agreement dated December 6, 2022, as  the same may be amended, restated, supplemented, modified or replaced from time to time, by  and between Borrower and Lender and the other lenders party thereto from time to time (the  “Purchase Agreement”). All interest calculations hereunder shall be computed on the basis of a  360-day year comprised of twelve (12) thirty (30) day months, and shall be payable in  accordance with the terms of this Note.   1. Payment.  1.1 Payment of Interest. Subject to Section 2.1, from and including the date  hereof to, but excluding, the Maturity Date, interest on this Note shall accrue on the Outstanding  Balance of this Note outstanding from time to time at a rate of interest per annum (the “Interest  Rate”) equal 7.50%.  All interest other than Default Interest shall be paid by the Company to the  Lender on the Effective Date for the period through the Maturity Date (the “Prepaid Interest”).  Default Interest shall be paid as provided for in the Purchase Agreement (but only the difference  between the total Default Interest amount and the Prepaid Interest shall be payable). The  Borrower acknowledges and agrees that the Prepaid Interest constitutes compensation to Lender  for arranging and providing the financing to the Borrower under this Note and the other  Transaction Documents and shall, therefore, be deemed fully earned on the date hereof, and not  subject to any refund or reimbursement for any reason. Prepaid Interest shall be paid in cash or in  

 

  2  4857-0618-4770.2  shares of the Company’s common stock, par value $.01 per share (“Shares”), as may be  determined by the Lender on the date hereof. In the event the Lender elects to receive Prepaid  Interest in Shares, the number of Shares shall equal the dollar amount of Prepaid Interest, divided  by the consolidated closing bid price immediately preceding the time the Company enters into  the Purchase Agreement, plus $.01.  The issuance of Shares shall be subject to compliance with  securities laws and Nasdaq rules and regulations. For all periods following the Maturity Date,  interest shall accrue on the Outstanding Balance at the prime rate announced to be then in effect  as published as the average rate in the Wall Street Journal (Northeast Edition) (the “Prime Rate”)  plus 50 basis points, for three months immediately following the Maturity Date, and thereafter  shall accrue at the Prime Rate plus 300 basis points, to be determined on the first day of each  calendar month for the succeeding calendar month. All accrued and unpaid interest shall be  payable on the Maturity Date or Extended Maturity Date (as defined below), as the case may be,  or if such day is not a Business Day, on the immediately succeeding Business Day (the “Interest  Payment Date”).  Interest shall be calculated on the basis of a 360-day year and actual days  elapsed.  1.2 Payment of Principal and Interest. On the Maturity Date, the Outstanding  Balance, including all principal under this Note, together with all accrued and unpaid interest  thereon and all other sums evidenced by this Note, shall be due and payable in cash, subject to  the next sentence.  At the Company’s election, the term of this Note can be extended one or more  times by notice to the Lender sent at least three (3) business days prior the Maturity Date, or  extended Maturity Date, as the case may be, but in no event to a date later than September 6,  2024 (such extended Maturity Date, as may be extended from time to time, the “Extended  Maturity Date”).  Upon payment in full of the Outstanding Balance of this Note and all accrued  and unpaid interest thereon, this Note will be automatically cancelled, whether or not this Note  has been surrendered. Should the Company elect to extend the term of this Note, following the  Maturity Date, interest shall be paid in cash, quarterly in arrears, on each of March 31, June 30,  September 30 and December 31.  As used herein, “Outstanding Balance” means as of any date of determination, the  outstanding principal amount of this Note, as reduced or increased, as the case may be, pursuant  to the terms hereof for payment, offset, or otherwise, plus accrued but unpaid interest, collection  and enforcements costs (including attorneys’ fees) incurred by Lender, transfer, stamp, issuance  and similar taxes and any other fees or charges incurred under this Note.  2. Defaults and Remedies.  2.1 Defaults. As used herein, the term “Event of Default” has the meaning  given such term in the Purchase Agreement.   2.2 Remedies. At any time and from time to time after Lender becomes aware  of the occurrence of any Event of Default that is continuing, Lender may exercise all of its rights  and remedies provided for in the Purchase Agreement or otherwise available under applicable  law or equity, including, subject to the Purchase Agreement, the right to accelerate this Note by  written notice to Borrower, with the Outstanding Balance becoming immediately due and  payable in cash. Notwithstanding the foregoing, upon the occurrence of any Event of Default  described in clauses (b), (c), (d), (e), or (f) of Section 9.1 of the Purchase Agreement, the  

 

  3  4857-0618-4770.2  Outstanding Balance as of the date of acceleration shall become immediately and automatically  due and payable in cash, without any written notice required by Lender or any other person.  Upon the occurrence of an Event of Default, interest shall accrue on the Outstanding Balance at  an interest rate equal to the Default Interest (as defined in the Purchase Agreement) rate. In  connection with acceleration described herein, Lender need not provide, and Borrower hereby  waives, any presentment, demand, protest or other notice of any kind, and Lender may  immediately and without expiration of any grace period enforce any and all of its rights and  remedies hereunder and all other remedies available to it under applicable law. Such acceleration  may be rescinded and annulled by Lender in accordance with the Purchase Agreement at any  time prior to payment hereunder and Lender shall have all rights as a holder of the Note until  such time, if any, as Lender receives full payment pursuant to this Section 2.2. No such  rescission or annulment shall affect any subsequent Event of Default or impair any right  consequent thereon. Nothing herein shall limit Lender’s right to pursue in one or more  arbitrations any other remedies available to it at law or in equity including, without limitation, a  decree of specific performance and/or injunctive relief. In the event the Lender accelerates, and  receives any payment (including any payment in full) of the Outstanding Balance and other  monetary obligations of the Borrower under the Transaction Documents, the Borrower shall not  be entitled to any refund of the Prepaid Interest.  3. Unconditional Obligation; No Offset. Borrower acknowledges that this Note is an  unconditional, valid, binding and enforceable obligation of Borrower not subject to offset,  deduction or counterclaim of any kind. Borrower hereby waives any rights of offset it now has or  may have hereafter against Lender, its successors and assigns, and agrees to make the payments  called for herein in accordance with the terms of this Note.  4. Waiver. No waiver of any provision of this Note shall be effective unless it is in  the form of a writing signed by the party granting the waiver. No waiver of any provision or  consent to any prohibited action shall constitute a waiver of any other provision or consent to any  other prohibited action, whether or not similar. No waiver or consent shall constitute a  continuing waiver or consent or commit a party to provide a waiver or consent in the future  except to the extent specifically set forth in writing.  5. Borrower Prepayment. Borrower shall have the right, exercisable at any time in its  sole and absolute discretion without penalty or fee, to prepay any amount of this Note (such  amount, the “Prepayment Amount”) by providing written notice to Lender at least two (2)  business days in advance of such prepayment (each, a “Prepayment Notice”). On the  prepayment date Borrower shall pay the Prepayment Amount in cash to Lender.  Upon any  prepayment, there shall be no refund of any Prepaid Interest.  6. Payment of Collection Costs. If this Note is placed in the hands of an attorney for  collection or enforcement prior to commencing arbitration or legal proceedings, or is collected or  enforced through any arbitration or legal proceeding, or Lender otherwise takes action to collect  amounts due under this Note or to enforce the provisions of this Note, then Borrower shall pay  the costs incurred by Lender for such collection, enforcement or action including, without  limitation, attorneys’ fees and disbursements.  

 

  4  4857-0618-4770.2  7. Opinion of Counsel. In the event that an opinion of counsel is needed for any  matter related to this Note, Lender has the right to have any such opinion provided by its  counsel; provided that such opinion shall be reasonably acceptable to Borrower.  8. Governing Law; Venue. This Note shall be construed and enforced in accordance  with, and all questions concerning the construction, validity, interpretation and performance of  this Note shall be governed by, the internal laws of the State of New York, without giving effect  to any choice of law or conflict of law provision or rule (whether of the State of New York or  any other jurisdiction) that would cause the application of the laws of any jurisdiction other than  the State of New York. The provisions set forth in the Purchase Agreement to determine the  proper venue for any disputes are incorporated herein by this reference.  9. Cancellation. After repayment of the entire Outstanding Balance, this Note shall  be deemed paid in full, shall automatically be deemed canceled, and shall not be reissued.  10. Amendments. The prior written consent of both parties hereto shall be required  for any change or amendment to this Note.  11. Assignments. Borrower may not assign this Note without the prior written consent  of Lender. This Note may be offered, sold, assigned or transferred by Lender without the consent  of Borrower.  12. Time is of the Essence. Time is expressly made of the essence with respect to  each and every provision of this Note and the documents and instruments entered into in  connection herewith.  13. Notices. Whenever notice is required to be given under this Note, unless  otherwise provided herein, such notice shall be given in accordance with the subsection of the  Purchase Agreement titled “Notices.”  14. Liquidated Damages. Lender and Borrower agree that in the event Borrower fails  to comply with any of the terms or provisions of this Note, Lender’s damages would be uncertain  and difficult (if not impossible) to accurately estimate because of the parties’ inability to predict  future interest rates, future share prices, future trading volumes and other relevant factors.  Accordingly, Lender and Borrower agree that any fees, balance adjustments, Prepaid Interest,  Default Interest or other charges assessed under this Note are not penalties but instead are  intended by the parties to be, and shall be deemed, liquidated damages (under Lender’s and  Borrower’s expectations that any such liquidated damages will, if allowed under applicable law,  tack back to the Effective Date for purposes of determining the holding period under Rule 144).  15. Waiver of Jury Trial. EACH OF LENDER AND BORROWER IRREVOCABLY  WAIVES ANY AND ALL RIGHTS SUCH PARTY MAY HAVE TO DEMAND THAT ANY  ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR IN ANY WAY  RELATED TO THIS NOTE OR THE RELATIONSHIPS OF THE PARTIES HERETO BE  TRIED BY JURY. THIS WAIVER EXTENDS TO ANY AND ALL RIGHTS TO DEMAND A  TRIAL BY JURY ARISING UNDER COMMON LAW OR ANY APPLICABLE STATUTE,  LAW, RULE OR REGULATION. FURTHER, EACH PARTY HERETO ACKNOWLEDGES  

 

  5  4857-0618-4770.2  THAT SUCH PARTY IS KNOWINGLY AND VOLUNTARILY WAIVING SUCH PARTY’S  RIGHT TO DEMAND TRIAL BY JURY.  16. Voluntary Agreement. Borrower has carefully read this Note and has asked any  questions needed for Borrower to understand the terms, consequences and binding effect of this  Note and fully understand them. Borrower has had the opportunity to seek the advice of an  attorney of Borrower’s choosing, or has waived the right to do so, and is executing this Note  voluntarily and without any duress or undue influence by Lender or anyone else.  17. Severability. If any part of this Note is construed to be in violation of any law,  such part shall be modified to achieve the objective of Borrower and Lender to the fullest extent  permitted by law and the balance of this Note shall remain in full force and effect.  [Remainder of page intentionally left blank; signature page follows] 

 

  4857-0618-4770.2  IN WITNESS WHEREOF, Borrower has caused this Note to be duly executed as of the  Effective Date.   BORROWER:      SUMMIT THERAPEUTICS INC.         By:    Name: Ankur Dhingra   Title: Chief Financial Officer    ACKNOWLEDGED, ACCEPTED AND AGREED:  LENDER:      Mahkam Zanganeh          

 

4891-4787-1298.2 EXHIBIT B-3  DUGGAN $100 MILLION NOTE  

 

    4880-9687-2514.2  EXHIBIT B-3  THIS NOTE HAS NOT BEEN REGISTERED UNDER THE UNITED STATES  SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY  STATE SECURITIES LAWS AND MAY NOT BE OFFERED, SOLD, PLEDGED,  ASSIGNED, OR OTHERWISE TRANSFERRED UNLESS (1) A REGISTRATION  STATEMENT WITH RESPECT HERETO IS EFFECTIVE UNDER THE SECURITIES  ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR (2) THE COMPANY  RECEIVES AN OPINION OF COUNSEL TO THE HOLDER OF THIS NOTE, WHICH  COUNSEL AND OPINION ARE REASONABLY SATISFACTORY TO THE  COMPANY, THAT THIS NOTE MAY BE OFFERED, SOLD, PLEDGED, ASSIGNED,  OR OTHERWISE TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT  AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR  APPLICABLE STATE SECURITIES LAWS.  PROMISSORY NOTE  Effective Date: December 6, 2022 U.S. $100,000,000  FOR VALUE RECEIVED, Summit Therapeutics Inc., a Delaware corporation  (“Borrower”), promises to pay to Robert Duggan or his successors or assigns (“Lender”), One  Hundred Twenty Million Dollars (the “Principal Amount”) and any interest, fees, charges, and  late fees on September 15, 2023 (the “Maturity Date”), subject to and in accordance with the  terms set forth herein, and to pay interest on the Outstanding Balance (as defined below) at the  rate equal to the Interest Rate (as defined below) per annum (subject to Section 2.2) from the  Effective Date until the Outstanding Balance is paid in full. This Promissory Note (this “Note”)  is issued and made effective as of December 6, 2022 (the “Effective Date”). This Note is issued  pursuant to, and subject to the terms of, that certain Note Purchase Agreement dated December  6, 2022, as the same may be amended, restated, supplemented, modified or replaced from time to  time, by and between Borrower and Lender and the other lenders party thereto from time to time  (the “Purchase Agreement”). All interest calculations hereunder shall be computed on the basis  of a 360-day year comprised of twelve (12) thirty (30) day months, and shall be payable in  accordance with the terms of this Note.   1. Payment.  1.1 Payment of Interest. Subject to Section 2.1, from and including the date  hereof to, but excluding, the Maturity Date, interest on this Note shall accrue on the Outstanding  Balance of this Note outstanding from time to time at a rate of interest per annum (the “Interest  Rate”) equal to 7.50%.  All interest (the “Prepaid Interest”) other than Default Interest shall be  paid by the Company to the Lender on the Effective Date for the period through February 15,  2023 (“February 2023”).  Default Interest shall be paid as provided for in the Purchase  Agreement (but only the difference between the total Default Interest amount and the Prepaid  Interest shall be payable). The Borrower acknowledges and agrees that the Prepaid Interest  constitutes compensation to Lender for arranging and providing the financing to the Borrower  under this Note and the other Transaction Documents and shall, therefore, be deemed fully  earned on the date hereof, and not subject to any refund or reimbursement for any reason.  

 

  2  4880-9687-2514.2  Prepaid Interest shall be paid in cash or in shares of the Company’s common stock, par value  $.01 per share (“Shares”), as may be determined by the Lender on the date hereof. In the event  the Lender elects to receive Prepaid Interest in Shares, the number of Shares shall equal the  dollar amount of Prepaid Interest, divided by the consolidated closing bid price immediately  preceding the time the Company enters into the Purchase Agreement, plus $.01.  The issuance of  Shares shall be subject to compliance with securities laws and Nasdaq rules and regulations. For  all periods following February 2023, interest shall accrue on the Outstanding Balance at the  prime rate announced to be then in effect as published as the average rate in the Wall Street  Journal (Northeast Edition) (the “Prime Rate”) plus 50 basis points, for three months  immediately following February 2023, and thereafter shall accrue at the Prime Rate  plus 300  basis points, to be determined on the first day of each calendar month for the succeeding  calendar month. All accrued and unpaid interest shall be payable on the Maturity Date or  Extended Maturity Date (as defined below), as the case may be, or if such day is not a Business  Day, on the immediately succeeding Business Day (the “Interest Payment Date”).  Interest  shall be calculated on the basis of a 360-day year and actual days elapsed.  1.2 Payment of Principal and Interest. On the Maturity Date, the Outstanding  Balance, including all principal under this Note, together with all accrued and unpaid interest  thereon and all other sums evidenced by this Note, shall be due and payable in cash, subject to  the next sentence.  At the Company’s election, the term of this Note can be extended one or more  times by notice to the Lender sent at least three (3) business days prior the Maturity Date, or  extended Maturity Date, as the case may be, but in no event to a date later than September 6,  2024 (such extended Maturity Date, as may be extended from time to time, the “Extended  Maturity Date”).  Upon payment in full of the Outstanding Balance of this Note and all accrued  and unpaid interest thereon, this Note will be automatically cancelled, whether or not this Note  has been surrendered. Following February 2023, interest shall be paid in cash, quarterly in  arrears, on each of March 31, June 30, September 30 and December 31.  As used herein, “Outstanding Balance” means as of any date of determination, the  outstanding principal amount of this Note, as reduced or increased, as the case may be, pursuant  to the terms hereof for payment, offset, or otherwise, plus accrued but unpaid interest, collection  and enforcements costs (including attorneys’ fees) incurred by Lender, transfer, stamp, issuance  and similar taxes and any other fees or charges incurred under this Note.  2. Defaults and Remedies.  2.1 Defaults. As used herein, the term “Event of Default” has the meaning  given such term in the Purchase Agreement.   2.2 Remedies. At any time and from time to time after Lender becomes aware  of the occurrence of any Event of Default that is continuing, Lender may exercise all of its rights  and remedies provided for in the Purchase Agreement or otherwise available under applicable  law or equity, including, subject to the Purchase Agreement, the right to accelerate this Note by  written notice to Borrower, with the Outstanding Balance becoming immediately due and  payable in cash. Notwithstanding the foregoing, upon the occurrence of any Event of Default  described in clauses (b), (c), (d), (e), or (f) of Section 9.1 of the Purchase Agreement, the  Outstanding Balance as of the date of acceleration shall become immediately and automatically  

 

  3  4880-9687-2514.2  due and payable in cash, without any written notice required by Lender or any other person.  Upon the occurrence of an Event of Default, interest shall accrue on the Outstanding Balance at  an interest rate equal to the Default Interest (as defined in the Purchase Agreement) rate. In  connection with acceleration described herein, Lender need not provide, and Borrower hereby  waives, any presentment, demand, protest or other notice of any kind, and Lender may  immediately and without expiration of any grace period enforce any and all of its rights and  remedies hereunder and all other remedies available to it under applicable law. Such acceleration  may be rescinded and annulled by Lender in accordance with the Purchase Agreement at any  time prior to payment hereunder and Lender shall have all rights as a holder of the Note until  such time, if any, as Lender receives full payment pursuant to this Section 2.2. No such  rescission or annulment shall affect any subsequent Event of Default or impair any right  consequent thereon. Nothing herein shall limit Lender’s right to pursue in one or more  arbitrations any other remedies available to it at law or in equity including, without limitation, a  decree of specific performance and/or injunctive relief. In the event the Lender accelerates, and  receives any payment (including any payment in full) of the Outstanding Balance and other  monetary obligations of the Borrower under the Transaction Documents, the Borrower shall not  be entitled to any refund of the Prepaid Interest.  3. Unconditional Obligation; No Offset. Borrower acknowledges that this Note is an  unconditional, valid, binding and enforceable obligation of Borrower not subject to offset,  deduction or counterclaim of any kind. Borrower hereby waives any rights of offset it now has or  may have hereafter against Lender, its successors and assigns, and agrees to make the payments  called for herein in accordance with the terms of this Note.  4. Waiver. No waiver of any provision of this Note shall be effective unless it is in  the form of a writing signed by the party granting the waiver. No waiver of any provision or  consent to any prohibited action shall constitute a waiver of any other provision or consent to any  other prohibited action, whether or not similar. No waiver or consent shall constitute a  continuing waiver or consent or commit a party to provide a waiver or consent in the future  except to the extent specifically set forth in writing.    5. Borrower Prepayment. Borrower shall have the right, exercisable at any time in its  sole and absolute discretion without penalty or fee, to prepay any amount of this Note (such  amount, the “Prepayment Amount”) by providing written notice to Lender at least two (2)  business days in advance of such prepayment (each, a “Prepayment Notice”). On the  prepayment date Borrower shall pay the Prepayment Amount in cash to Lender. Upon any  prepayment, there shall be no refund of any Prepaid Interest.  6. Payment of Collection Costs. If this Note is placed in the hands of an attorney for  collection or enforcement prior to commencing arbitration or legal proceedings, or is collected or  enforced through any arbitration or legal proceeding, or Lender otherwise takes action to collect  amounts due under this Note or to enforce the provisions of this Note, then Borrower shall pay  the costs incurred by Lender for such collection, enforcement or action including, without  limitation, attorneys’ fees and disbursements.  

 

  4  4880-9687-2514.2  7. Opinion of Counsel. In the event that an opinion of counsel is needed for any  matter related to this Note, Lender has the right to have any such opinion provided by its  counsel; provided that such opinion shall be reasonably acceptable to Borrower.  8. Governing Law; Venue. This Note shall be construed and enforced in accordance  with, and all questions concerning the construction, validity, interpretation and performance of  this Note shall be governed by, the internal laws of the State of New York, without giving effect  to any choice of law or conflict of law provision or rule (whether of the State of New York or  any other jurisdiction) that would cause the application of the laws of any jurisdiction other than  the State of New York. The provisions set forth in the Purchase Agreement to determine the  proper venue for any disputes are incorporated herein by this reference.  9. Cancellation. After repayment of the entire Outstanding Balance, this Note shall  be deemed paid in full, shall automatically be deemed canceled, and shall not be reissued.  10. Amendments. The prior written consent of both parties hereto shall be required  for any change or amendment to this Note.  11. Assignments. Borrower may not assign this Note without the prior written consent  of Lender. This Note may be offered, sold, assigned or transferred by Lender without the consent  of Borrower.  12. Time is of the Essence. Time is expressly made of the essence with respect to  each and every provision of this Note and the documents and instruments entered into in  connection herewith.  13. Notices. Whenever notice is required to be given under this Note, unless  otherwise provided herein, such notice shall be given in accordance with the subsection of the  Purchase Agreement titled “Notices.”  14. Liquidated Damages. Lender and Borrower agree that in the event Borrower fails  to comply with any of the terms or provisions of this Note, Lender’s damages would be uncertain  and difficult (if not impossible) to accurately estimate because of the parties’ inability to predict  future interest rates, future share prices, future trading volumes and other relevant factors.  Accordingly, Lender and Borrower agree that any fees, balance adjustments, Prepaid Interest,  Default Interest or other charges assessed under this Note are not penalties but instead are  intended by the parties to be, and shall be deemed, liquidated damages (under Lender’s and  Borrower’s expectations that any such liquidated damages will, if allowed under applicable law,  tack back to the Effective Date for purposes of determining the holding period under Rule 144).  15. Waiver of Jury Trial. EACH OF LENDER AND BORROWER IRREVOCABLY  WAIVES ANY AND ALL RIGHTS SUCH PARTY MAY HAVE TO DEMAND THAT ANY  ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR IN ANY WAY  RELATED TO THIS NOTE OR THE RELATIONSHIPS OF THE PARTIES HERETO BE  TRIED BY JURY. THIS WAIVER EXTENDS TO ANY AND ALL RIGHTS TO DEMAND A  TRIAL BY JURY ARISING UNDER COMMON LAW OR ANY APPLICABLE STATUTE,  LAW, RULE OR REGULATION. FURTHER, EACH PARTY HERETO ACKNOWLEDGES  

 

  5  4880-9687-2514.2  THAT SUCH PARTY IS KNOWINGLY AND VOLUNTARILY WAIVING SUCH PARTY’S  RIGHT TO DEMAND TRIAL BY JURY.  16. Voluntary Agreement. Borrower has carefully read this Note and has asked any  questions needed for Borrower to understand the terms, consequences and binding effect of this  Note and fully understand them. Borrower has had the opportunity to seek the advice of an  attorney of Borrower’s choosing, or has waived the right to do so, and is executing this Note  voluntarily and without any duress or undue influence by Lender or anyone else.  17. Severability. If any part of this Note is construed to be in violation of any law,  such part shall be modified to achieve the objective of Borrower and Lender to the fullest extent  permitted by law and the balance of this Note shall remain in full force and effect.  [Remainder of page intentionally left blank; signature page follows] 

 

  4880-9687-2514.2  IN WITNESS WHEREOF, Borrower has caused this Note to be duly executed as of the  Effective Date.   BORROWER:      SUMMIT THERAPEUTICS INC.         By:    Name: Ankur Dhingra   Title: Chief Financial Officer    ACKNOWLEDGED, ACCEPTED AND AGREED:  LENDER:      Robert Duggan          

 

  4891-4787-1298.2    EXHIBIT C    Investor Questionnaire    ACCREDITED INVESTOR QUESTIONNAIRE    The purpose of this Questionnaire is to determine whether you are an “accredited investor” as that  term is defined in Regulation D promulgated under the Securities Act of 1933, as amended  (the “Act”).  The undersigned represents that the information contained herein is complete  and accurate.  The undersigned makes one of the following representations regarding its income, net worth, status  as a “family client” of a “family office,” and/or certain professional certifications or designations  and certain related matters and has checked the applicable representation:   [__] The undersigned’s income1 during each of the last two years exceeded $200,000  or, if the undersigned is married or has a spousal equivalent2, the joint income of  the undersigned and the undersigned’s spouse or spousal equivalent, as applicable,  during each of the last two years exceeded $300,000, and the undersigned  reasonably expects the undersigned’s income, from all sources during this year, will  exceed $200,000 or, if the undersigned is married or has a spousal equivalent, the  joint income of undersigned and the undersigned’s spouse or spousal equivalent, as  applicable, from all sources during this year will exceed $300,000.   [__] The undersigned’s net worth,3 including the net worth of the undersigned’s spouse  or spousal equivalent, as applicable, is in excess of $1,000,000. For purposes of  calculating net worth: (i) your primary residence shall not be included as an asset;  (ii) indebtedness that is secured by your primary residence, up to the estimated fair  market value of the primary residence at the time of the sale of Notes, shall not be  included as a liability (except that if the amount of such indebtedness outstanding  at the time of the sale of Notes exceeds the amount outstanding 60 days before such  time, other than as a result of the acquisition of the primary residence, the amount  of such excess shall be included as a liability); and (iii) indebtedness that is secured    1 For purposes of this Questionnaire, “income” means adjusted gross income, as reported for federal income tax purposes,  increased by the following amounts:  (a) the amount of any tax exempt interest income received, (b) the amount of losses claimed  as a limited partner in a limited partnership, (c) any deduction claimed for depletion, (d) amounts contributed to an IRA or Keogh  retirement plan, (e) alimony paid, and (f) any amounts by which income from long-term capital gains has been reduced in  arriving at adjusted gross income pursuant to the provisions of Section 1202 of the Code.  2 For purposes of this Questionnaire, “spousal equivalent” means a cohabitant occupying a relationship generally equivalent to  that of a spouse.  3 For purposes of this Questionnaire, “net worth” means the excess of total assets, excluding your primary residence, at fair  market value over total liabilities, including your mortgage or any other liability secured by your primary residence only if and to  the extent that it exceeds the value of your primary residence. Net worth should include the value of any other shares of stock or  options held by you and your spouse or spousal equivalent and any personal property owned by you or your spouse or spousal  equivalent (e.g. furniture, jewelry, other valuables, etc.).  For the purposes of calculating joint net worth: joint net worth can be  the aggregate net worth of you and your spouse or spousal equivalent; assets need not be held jointly to be included in the  calculation.  

 

  4891-4787-1298.2  by your primary residence in excess of the estimated fair market value of the  primary residence at the time of the sale of Notes shall be included as a liability.   [__] The undersigned is a holder in good standing of one or more of the following  certifications or designations administered by the Financial Industry Regulatory  Authority, Inc. (FINRA): the Licensed General Securities Representative (Series  7), Licensed Investment Adviser Representative (Series 65), or Licensed Private  Securities Offerings Representative (Series 82).   [__] The undersigned is a “family client,” as defined in rule 202(a)(11)(G)-1 under the  Investment Advisers Act of 1940, as amended (the “Advisers Act”), of a family  office as defined in rule 202(a)(11)(G)-1 under the Advisers Act, (i) with assets  under management in excess of $5,000,000, (ii) that is not formed for the specific  purpose of acquiring the securities offered, and (iii) whose prospective investment  is directed by a person who has such knowledge and experience in financial and  business matters that such family office is capable of evaluating the merits and risks  of the prospective investment, and whose prospective investment is directed by  such family office pursuant to clause (iii) of this sentence.   [__] The undersigned is a “knowledgeable employee” as defined in rule 3c-5(a)(4) under  the United States Investment Company Act of 1940, director, executive officer or  general partner of the issuer of the Notes (i.e., the Company).   [__] The undersigned cannot make any of the representations set forth above.    IN WITNESS WHEREOF, the undersigned has executed this Accredited Investor Questionnaire as  of the date written below.      ______________________________

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