Document:

mla_com_ex10_23

Exhibit 10.23

ADDENDUM DATED AS OF AUGUST 31, 2000

 TO THE MASTER LEASE AGREEMENT

 DATED AS OF AUGUST 2,2000 (THE "AGREEMENT")

 BETWEEN EXELIXIS, INC. ("LESSEE")

 ACTING ON BEHALF OF ITSELF AND ITS AFFILIATES,

 AND COMDISCO LABORATORY AND SCIENTIFIC GROUP,

 A DIVISION OF COMDISCO, INC. ("LESSOR")

The terms and conditions of this Addendum shall be
incorporated into the Agreement and supersedes the Agreement to the extent
expressly provided herein.  Each capitalized terms used herein and not otherwise
defined shall have the same meaning attributed to it in the Agreement.

The terms and conditions of the following sections of the
Agreement are hereby modified:

	Add
a new SECTION 1A, AFFILIATES

"Exelixis, Inc. shall,
without notice, be jointly and severally liable for the due performance of the
obligations of its Affiliates under all Equipment Schedules executed hereunder,
including, without limitation, all terms and conditions negotiated by its
Affiliate."

	SECTION 3, RENT AND PAYMENT

Delete the last sentence and
replace with the following: "If any payment is not made within ten (10)
days of the due date, Lessee will pay interest from the due date at the Overdue
Rate."

	SECTION 7.1, CARE, USE AND MAINTENANCE

Delete the second, third and
fourth sentences and replace with the following: "Lessee shall be
responsible for maintenance of the Equipment and, if Lessee does not purchase
the Equipment pursuant to the terms of a Schedule, Lessee shall bring the
Equipment to original manufacturer specifications applicable at the Commencement
Date of the Schedule, normal wear and tear excepted, and re-certify the
Equipment as eligible for manufacturer's maintenance at the expiration of the
lease term."

	SECTION 7.2, ATTACHMENTS AND RECONFIGURATIONS

At the end of line 1, insert the
words "which consent will not be unreasonably withheld,".

	SECTION 8, REPRESENTATIONS AND WARRANTIES OF LESSEE

In paragraph (e), line 2, before
the word "clinical" insert the word "human".

	SECTION 9, DELIVERY AND RETURN OF EQUIPMENT

In line 9, after the word
"depreciation)", delete the remainder of the sentence and replace with
the following: "and in accordance with Section 7.1, and accompanied by all
spare parts and accessories and maintenance records for the duration of the
Schedule."

	SECTION 13.3, MITIGATION

	In line 2, delete the words
"its best" and insert the words "commercially
reasonable".

	In paragraph (b), delete the parenthetical and replace
with the following: "(discounted at the implicit interest rate of the re-
lease as determined by Lessor based upon the new lessee's credit
rating)".

	SECTION 14.3, BINDING NATURE

Line 3, after the word
"OBLIGATIONS" insert the words "WITHOUT THE PRIOR WRITTEN CONSENT
OF LESSOR, WHICH SHALL NOT BE UNREASONABLE WITHHELD".

	SECTION 14.10, ADDITIONAL DOCUMENTS

In line 5, before the word
"counsel" insert the words "in-house".  Add the following at
the end of this section: "Lessor will accept Lessee's certified board
resolutions in lieu of an opinion from Lessee's in-house counsel with respect to
the representations and warranties set forth in Section 8." 

	SECTION 14.12, DEFINITIONS

	Add the following definition:
"Affiliates of Exelixis, Inc," shall mean those enterprises in which
Exelixis, Inc., or its parent company owns and/or shall own at anytime after the
date hereof, directly or indirectly, the majority of the voting stock, or a
controlling interest, including without limitation all present Affiliates of
Exelixis, Inc.

	Add the following definition: "Lessee" shall
mean, with respect to any Equipment Schedule, the Affiliate of Exelixis, Inc.
entering into such Equipment Schedule, or Exelixis, Inc., if Exelixis, Inc.
enters into such Equipment Schedule.

IN WITNESS WHEREOF, the parties have caused this Addendum to
be executed by their authorized representatives as of the date and year set
forth below.

ACCEPTED AND AGREED TO:

	
Exelixis, Inc.
	
Comdisco Laboratory and Scientific Group, a

division of Comdisco, Inc.

	
By: 
	
By: 

	
Printed Name: 
	
Printed Name: 

	
Title: 
	
Title: 

	
Date: 
	
Date:mla_com_ex10_24

Exhibit 10.24

AMENDMENT NO. 1 TO 

MASTER LEASE AGREEMENT

DATED AUGUST 2, 2000 (the
"Lease") 

BY AND BETWEEN 

EXELIXIS, INC. ("Lessee") 

ACTING ON BEHALF OF ITSELF AND ITS AFFILIATES, 

AND COMDISCO LABORATORY AND SCIENTIFIC GROUP, 

A DIVISION OF COMDISCO, INC. ("Lessor')

WHEREAS, Lessor and Lessee desire to enter into the
Lease; and

WHEREAS, Lessor and Lessee desire to amend certain provisions
of the Lease as hereafter provided; and

WHEREAS, the Amendment shall be deemed to have been entered
into contemporaneously with and integrated into the terms and conditions of the
Lease.

NOW THEREFORE, for good and valuable consideration, Lessor
and Lessee hereby agree to amend the Lease as follows:

1.Lessee agrees to maintain a financial status of all
of the following during the term of the Lease and any extension or renewal
thereof

a.Tangible net worth of not less than
$20,000,000.00;

b.Cash or equivalents of not less than
$20,000,000.00.

2.In addition, Lessee agrees to provide Lessor with
quarterly financial statements within forty-five (45) days after the end of each
fiscal quarter and audited annual financial statements within one hundred twenty
(120) days of the end of each fiscal year.

3.Failure of Lessee to maintain any one of the above
at any time during the Lease term and any extension or renewal thereof or the
failure to make any payment due under the Lease is an Event of Default under the
Lease which Lessee must, within ten (10) business days, provide a Letter of
Credit from a bank acceptable to Lessor for one hundred percent (100%) of all
rent then due or to become due under the lease as of the date of the default.
Along with the Letter of Credit, Lessee shall also execute a Letter of Credit
Agreement with Lessor.  The Letter of Credit and Letter of Credit Agreement
shall be in a form substantially similar to Exhibits A & B attached and
incorporated herein but in any event approved by Lessor.

4.Lessor shall also be entitled to any or all
remedies or actions in the event of default, as provided in the Lease, and this
Amendment shall not be construed to limit Lessor's rights in any way.

Except as set out herein, Lessor and Lessee hereby agree that
the terms and conditions of the Lease shall remain in full force and effect as
entered into by the parties on or prior to the date hereof.

	
EXELIXIS, INC.

as Lessee

By:

Title:

Date:

	
COMDISCO LABORATORY AND SCIENTIFIC GROUP,

A DIVISION OF COMDISCO, INC.

as Lessor

By:

Title:

Date:

EXHIBIT A

(On Bank Letterhead)

{DATE}

BENEFICIARY: 

Comdisco Laboratory and Scientific Group, 

a division of Comdisco, Inc., or Transferee 

6111 N. River Road

Rosemont, IL 60018

Gentlemen:

We hereby establish our Irrevocable Standby Letter of Credit
No. _________ in your favor for account of , for a sum not to exceed AND /100
DOLLARS ($) available by your draft drawn at sight on us.

Draft must be accompanied by: Your statement signed by an
officer of Comdisco Laboratory and Scientific Group, a division of Comdisco,
Inc. certifying that Exelixis, Inc. has defaulted under that certain Master
Lease Agreement dated August 2, 2000 between Exelixis, Inc. and Comdisco
Laboratory and Scientific Group, a division of Comdisco, Inc., and the original
of this Letter of Credit

This Letter of Credit expires __________. All drafts drawn
hereunder must be present for payment at our office at
___________________________________________________ on or before that date.

It is a condition of this Irrevocable Standby Letter of
Credit that it shall be deemed automatically extended without amendment for one
(1) year from the present or any future expiration date hereof but not beyond
end of lease term.  Should we elect not to renew this Standby Letter of Credit,
we shall notify you of such election 45 days prior to any such date.  All
notices shall be in writing, sent by certified mail, return receipt requested
and addressed to you at the above address, ATTENTION: Credit Manager.
Notwithstanding receipt by you of such notice, you may draw hereby by means of
your draft on us at sight accompanied by the documents required herein, until
such expiration date.

This Letter of Credit may be transferred by you at any time
and such transfer shall be deemed effective and binding on us upon receipt of
written notice of such transfer from you when accompanied by the original of
this Letter of Credit.

We hereby agree that drafts drawn strictly in compliance with
the terms of this credit and any amendments thereto shall meet with due honor
upon presentation at our office at .

Title

EXHIBIT B

LETTER OF CREDIT

AGREEMENT

Stand-by Letter of Credit Agreement dated __________, by and
between Exelixis, Inc. ("Lessee") located at 170 Harbor Way, South San
Francisco, CA 94083 and Comdisco Laboratory and Scientific Group, a division of
Comdisco, Inc. ("Lessor") with offices at 6111 N. River Road,
Rosemont, IL 60018.

WHEREAS, Lessee has requested that Lessor lease various
equipment, as further described in the Lease (the "Equipment"), to
Lessee; and

WHEREAS, Lessor has agreed to lease the Equipment to Lessee
upon the condition that an Irrevocable Stand-by Letter of Credit shall be
outstanding for the full term of the Master Lease Agreement to additionally
secure Lessee's performance under the Lease.

NOW THEREFORE, in consideration of and as an inducement to
Lessor to lease the Equipment to Lessee, the parties hereto agree as
follows:

	Lessee and Lessor have entered or shall enter into a
Master Lease Agreement and one or more Schedules thereunder for leasing the
Equipment, (together the "Lease"), all of which shall be covered by
the terms of this Agreement

	Concurrently with the execution for this Agreement,
Lessee shall cause to be delivered to Lessor in the form attached hereto as
Exhibit A, an Irrevocable Stand-by Letter of Credit issued by a bank acceptable
to Lessor, which Letter of Credit shall be in the amount of AND /100 dollars ($)
("Letter of Credit") and shall be outstanding until
____________________, with annual renewals until end of lease term.

	Receipt by Lessor of notice that the Letter of Credit
will not be renewed on any expiration date, as provided therein, shall
constitute a material default by Lessee under the terms and conditions of the
Lease.  Lessor shall then have the right to draw upon the Letter of Credit up to
its full amount and to apply the proceeds as set out in paragraph 4, below,
unless at least thirty (30) days prior to said expiration date Lessee replaces
the Letter of Credit with a Letter of Credit which has been issued by a bank
acceptable to Lessor and has the same terms and conditions as the replaced
Letter of Credit

	Upon the occurrence of any Event of Default under the
Lease which shall include Amendment 001, and at any time while a default is
continuing, Lessor shall have the right to draw upon the Letter of Credit up to
its full amount and to apply the proceeds thereof first to any reasonable costs
and expenses incurred by Lessor in the enforcement of the terms of the Lease and
the exercise of its rights and remedies, then to the unpaid balance of all sums
payable under the Lease, whether by acceleration or otherwise, with any excess
proceeds being refundable to Lessee, and Lessee remaining liable for any
deficiency.

	Waiver by Lessor of a default shall not constitute a
continuing waiver of default, of the same provision or any other provision of
the Lease.  Additionally, failure of Lessor to draw upon the Letter of Credit at
any time shall not be construed as a waiver of Lessor's right to draw upon the
Letter of Credit as herein set forth at any other time.

	The exercise by Lessor of its rights under this Agreement
shall be deemed to be in addition to and not in lieu of any other rights and
remedies of Lessor under the Lease, or any other document relating to the Lease
and shall not be construed in any manner to represent satisfaction of the
obligations of Lessee under or with respect to the Lease.

IN WITNESS WHEREOF, the parties have caused this Agreement to
be executed as of the date set forth above.

	
EXELIXIS, INC.

as Lessee

By:

Title:

Date:

	
COMDISCO LABORATORY AND SCIENTIFIC GROUP,

A DIVISION OF COMDISCO, INC.

as Lessor

By:

Title:

Date:

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