Document:

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                                                                    EXHIBIT 4.2

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE
COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN
EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"); AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT
TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO
AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS.

                                     WARRANT

                      TO PURCHASE SHARES OF COMMON STOCK OF

                       CHROMAVISION MEDICAL SYSTEMS, INC.

THIS CERTIFIES that, for value received, Safeguard Delaware, Inc. and its
successors and assigns (the "HOLDER") is entitled, upon the terms and subject to
the conditions hereinafter set forth, at such times as provided in Section 4
hereof, to subscribe for and purchase from CHROMAVISION MEDICAL SYSTEMS, INC., a
Delaware corporation (the "COMPANY"), 975,000 shares (the "WARRANT SHARES") of
common stock, $0.01 par value per share ("COMMON STOCK"), of the Company. The
purchase price of one share of Common Stock under this Warrant shall be the
Exercise Price (as defined below). This Warrant is being issued in connection
with the Securities Purchase Agreement dated on or about the date hereof (the
"PURCHASE AGREEMENT") entered into between the Company and the Holder.

1.      DEFINITIONS. Capitalized terms used herein and not otherwise defined
        shall have the meaning ascribed thereto in the Purchase Agreement. As
        used in this Warrant, the following terms shall have the following
        respective meanings:

        "AFFILIATE" shall mean, at any time, and with respect to any Person, (a)
        any other Person that at such time directly or indirectly through one or
        more intermediaries Controls, or is Controlled by, or is under common
        Control with, such first Person, and (b) any Person beneficially owning
        or holding, directly or indirectly, 10% or more of any class of voting
        or equity interests of the Company or any Subsidiary or any corporation
        of which the Company and its Subsidiaries beneficially own or hold, in
        the aggregate, directly or indirectly, 10% or more of any class of
        voting or equity interests. As used in this definition, "CONTROL" means
        the possession, directly or indirectly, of the power to direct or cause
        the direction of the management and policies of a Person, whether
        through the ownership of voting securities, by contract or otherwise.

        "COMMENCEMENT DATE" shall mean June [10], 2002.

        "CONVERTIBLE SECURITIES" shall mean (i) any security convertible, with
        or without consideration, into any Common Stock (including any option to
        purchase such a convertible security and options granted to employees of
        the Company under a stock option plan or similar arrangement), (ii) any
        security carrying any warrant or right to

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        subscribe to or purchase any Common Stock or (iii) any such warrant or
        right, all as outstanding on the Commencement Date, other than any of
        the foregoing held by the Holder or any of its Affiliates on or after
        the date hereof.

        "CONVERTIBLE SECURITIES EVENT" shall mean the conversion or exercise by
        a Person of Convertible Securities.

        "EXCHANGE ACT" shall mean the Securities Exchange Act of 1934, as
        amended.

        "EXERCISE PRICE" shall mean in connection with any Exercise of this
        Warrant the per share exercise or conversion price of any Convertible
        Security to which such Exercise relates.

        "HOLDER" shall mean the Holder or any subsequent permitted transferee of
        this Warrant.

        "PERSON" or "PERSON" shall mean an individual, partnership, corporation,
        limited liability company, association, trust, unincorporated
        organization, or a government or agency or political subdivision
        thereof.

        "PRICING PERIOD" shall mean the period of twenty (20) consecutive
        Trading Days immediately preceding any Exercise Date.

        "PRINCIPAL MARKET" shall mean the Principal Market or such Approved
        Market on which the Common Stock is then principally traded.

        "SECURITIES ACT" shall mean the Securities Act of 1933, as amended.

        "TRADING DAY" shall mean (x) if the Common Stock is listed on the New
        York Stock Exchange or the American Stock Exchange, a day on which there
        is trading on such stock exchange, or (y) if the Common Stock is not
        listed on either of such stock exchanges but sale prices of the Common
        Stock are reported on an automated quotation system, a day on which
        trading is reported on the principal automated quotation system on which
        sales of the Common Stock are reported, or (z) if the foregoing
        provisions are inapplicable, a day on which quotations are reported by
        National Quotation Bureau Incorporated.

2.      TITLE OF WARRANT. The Company shall register this Warrant, upon records
        to be maintained by the Company for that purpose, in the name of the
        record holder hereof from time to time. The Company may deem and treat
        the registered holder of this Warrant as the absolute owner hereof for
        the purpose of any exercise hereof or any distribution to the holder,
        and for all other purposes, and the Company shall not be affected by
        notice to the contrary except as provided herein.

                With the written consent of the Company, such written consent
        not to be unreasonably withheld, subject to compliance with applicable
        laws, this Warrant and all rights hereunder are transferable in a single
        transfer, at the office or agency of the Company by the holder hereof in
        person or by duly authorized attorney, upon surrender of this Warrant
        together with (a) an Assignment Form in the form attached hereto as
        Exhibit A, and (b) any other documentation reasonably necessary to
        satisfy the Company

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        that such transfer is in compliance with all applicable securities laws;
        provided, that no such transfer may be made to a person that is not an
        "accredited investor" as defined in Rule 501 of Regulation D of the
        Securities Act; and provided, further, that no consent of the Company is
        required for any transfer or assignment in whole or in part from time to
        time to an Affiliate of the Holder or the then holder of this Warrant
        that is an "accredited investor." If this Warrant is duly assigned in
        accordance with the terms hereof, then the Company agrees, upon the
        request of the assignee, to amend or supplement promptly any effective
        registration statement covering the Warrant Shares so that such assignee
        is entitled to be a selling stockholder thereunder.

3.      AUTHORIZATION OF SHARES. The Company hereby covenants that all shares of
        Common Stock which may be issued upon the exercise of rights represented
        by this Warrant will, upon exercise of the rights represented by this
        Warrant and payment of the Exercise Price as set forth herein, be duly
        authorized, validly issued, fully paid and nonassessable and free from
        all taxes, liens, encumbrances and charges in respect of the issue
        thereof (other than taxes in respect of any transfer occurring
        contemporaneously with such issue or otherwise specified herein).

4.      EXERCISE OF WARRANT.

        (a) Exercise (each an "EXERCISE") of the purchase rights represented by
        this Warrant may be made as contemplated by Section 4(b) below. In each
        Exercise, to the extent that Warrant Shares remain available for
        purchase by the Holder hereunder, this Warrant shall be exercisable into
        a number of Warrant Shares equal to the aggregate number of shares of
        Common Stock that have been issued or are issuable in respect of
        Convertible Securities Events described in the Conversion Notice (as
        defined in Section 4(b) below).

        (b) The Company shall promptly notify the Holder in writing following
        the close of each fiscal quarter regarding, among other things,
        conversions or exercises of Convertible Securities during such quarterly
        period. Such notice to the Holder (a "CONVERSION NOTICE") shall contain
        (i) the number of shares of Common Stock any such Person received or to
        be received from converting or exercising each such Convertible
        Securities, (ii) the effective time of such conversion or exercise,
        (iii) the per share exercise or conversion price of each such
        Convertible Security, and (iv) a calculation as of the end of such
        quarterly period of the number of Warrant Shares issuable hereunder. To
        the extent that Warrant Shares remain available for purchase by the
        Holder hereunder, the Holder may exercise this Warrant in connection
        with any Convertible Securities Event identified in a Conversion Notice
        by delivering a notice of exercise duly executed (which delivery may be
        by facsimile) to the Company at the principal office of the Company (or
        such other office or agency of the Company as it may designate by notice
        in writing to the registered holder hereof at the address of such holder
        appearing on the books of the Company) within nine (9) months of
        receiving such Conversion Notice (such nine-month period being referred
        to herein as the "EXERCISE PERIOD"). At any time during any applicable
        Exercise Period, following payment to the Company (the date of such
        payment being referred to herein as the "EXERCISE DATE") of an amount
        equal to the product of the Exercise Price multiplied by the number of
        the Warrant Shares the Holder is entitled to and desires to purchase,
        the Holder of this Warrant shall be entitled to

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        receive a certificate for the number of shares of Common Stock so
        purchased. Following each applicable Exercise Period, the 975,000
        maximum (as adjusted as contemplated by Section 12 below) number of
        Warrant Shares that the Holder was entitled to purchase on the date of
        this Warrant will be reduced by the number of shares the Holder was
        entitled to purchase during such Exercise Period, whether or not so
        purchased. Payment of the Exercise Price of the shares shall be by
        certified check or cashier's check or by wire transfer to an account
        designated by the Company in an aggregate amount equal to the Exercise
        Price multiplied by the number of Warrant Shares to be received. The
        Holder shall not be required to physically surrender this Warrant to the
        Company in connection with an Exercise and the rights of the Holder
        hereunder shall remain outstanding until the earlier of (i) the date on
        which no Warrant Shares remain available for purchase by the Holder
        hereunder and (ii) the date on which there are no Convertible Securities
        outstanding.

        (c) The Company shall deliver certificates for shares of Common Stock
        purchased hereunder within three (3) Trading Days after the Exercise
        Date. In lieu of delivering physical certificates representing the
        Warrant Shares issuable upon conversion of this Warrant, provided the
        Company's transfer agent is a participant in the Depository Trust
        Company ("DTC") Fast Automated Securities Transfer ("FAST") program,
        upon request of the holder, the Company shall use its best efforts to
        cause its transfer agent to electronically transmit the Warrant Shares
        issuable upon exercise to the holder, by crediting the account of the
        holder's prime broker with DTC through its Deposit Withdrawal Agent
        Commission ("DWAC") system. The time periods for delivery described
        above shall apply to the electronic transmittals through the DWAC
        system. The Company agrees to use its best commercially reasonable
        efforts to coordinate with DTC to accomplish this objective.

5.      NO FRACTIONAL SHARES OR SCRIP. No fractional Warrants Shares or scrip
        representing fractional Warrant Shares shall be issued upon the exercise
        of this Warrant. Any fractional share or scrip shall be rounded up to
        the nearest whole number.

6.      CHARGES, TAXES AND EXPENSES. Issuance of certificates for Warrant Shares
        shall be made without charge to the holder hereof for any issue or
        transfer tax or other incidental expense in respect of the issuance of
        such certificate, all of which taxes and expenses shall be paid by the
        Company, and such certificates shall be issued in the name of the Holder
        or in such name or names as may be directed by the Holder.

7.      NO RIGHTS AS SHAREHOLDER UNTIL EXERCISE. Subject the provisions of any
        other written agreement between the Company and the Holder, prior to an
        exercise of this Warrant as provided herein, the Holder shall not be
        entitled to vote or receive dividends or be deemed the holder of any
        Warrant Shares or any other securities of the Company that may at any
        time be issuable on the exercise hereof for any purpose, nor shall
        anything contained herein be construed to confer upon the Holder, as
        such, any of the rights of a stockholder of the Company or any right to
        vote for the election of directors or upon any matter submitted to
        stockholders at any meeting thereof, or to give or withhold consent to
        any corporate action (whether upon any recapitalization, issuance of
        stock, reclassification of stock, change of par value, or change of
        stock to no par value,

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        consolidation, merger, conveyance or otherwise) or to receive notice of
        meetings, or to receive dividends or subscription rights. However, at
        the time of the exercise of this Warrant pursuant to Section 4 hereof,
        the Warrant Shares so purchased hereunder shall be deemed to be issued
        to such Holder as the record owner of such shares as of the close of
        business on the applicable Exercise Date.

8.      REMEDIES. If the Company shall fail to deliver to the Holder the Warrant
        Shares to be issued to the Holder hereunder by the third (3rd) Trading
        Day following the Exercise Date, whether by physical delivery of
        certificates or by book-entry transfer through DTC for such Warrant
        Shares, the Holder shall be entitled to any remedies available to it
        under this Warrant or the Transaction Documents or at law or in equity.

9.      LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT; DENOMINATION. In the
        event that the Holder notifies the Company that its Warrant has been
        lost, stolen or destroyed, then a replacement Warrant identical in all
        respects to the original Warrant shall be delivered to the Holder by the
        Company within three (3) Trading Days, provided that such Holder
        executes and delivers to the Company an agreement reasonably
        satisfactory to the Company to indemnify the Company from any loss
        incurred by it in connection with such Warrant. No service charge will
        be made for such registration, replacement, transfer or exchange.

10.     SATURDAYS, SUNDAYS, HOLIDAYS, ETC. If the last or appointed day for the
        taking of any action or the expiration of any right required or granted
        herein shall be a Saturday, Sunday or a legal holiday, then such action
        may be taken or such right may be exercised on the next succeeding day
        not a legal holiday.

11.     VOLUNTARY ADJUSTMENT BY THE COMPANY. The Company may at its option, at
        any time during the term of this Warrant, reduce but not increase the
        then current Exercise Price to any amount and for any period of time
        deemed appropriate by the Board of Directors of the Company.

12.     EFFECT OF CERTAIN EVENTS; ADJUSTMENT OF EXERCISE PRICE AND NUMBER OR
        WARRANT SHARES. To the extent that the occurrence of any transaction
        entitles the holder of any Convertible Security to any cash, stock,
        other securities, assets or any other property or consideration with or
        without the exercise or conversion of such Convertible Security, which
        such holder would have owned or been entitled to receive upon or after
        the happening of such transaction had such holder exercised such
        Convertible Security immediately prior thereto, the Holder shall
        similarly be entitled to receive such consideration with or without the
        Exercise of this Warrant. To the extent that the exercise or conversion
        price of any Convertible Security or the number of shares of Common
        Stock that are issuable upon exercise or conversion of any such
        Convertible Security are adjusted as a result of any declaration or
        payment of any dividend, any distribution or distributions on any equity
        security of the Company, subdivision or combination of shares of Common
        Stock into larger or smaller numbers of shares or any reclassification
        or like event, the applicable Exercise Price of this Warrant and the
        number of Warrant Shares that the Holder is entitled to purchase
        hereunder shall be similarly adjusted.

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13.     MISCELLANEOUS.

        (a)  Issue Date; Choice of Law; Venue; Jurisdiction; No Jury Trial. THE
        PROVISIONS OF THIS WARRANT SHALL BE CONSTRUED AND SHALL BE GIVEN EFFECT
        IN ALL RESPECTS AS IF IT HAD BEEN ISSUED AND DELIVERED BY THE COMPANY ON
        THE DATE HEREOF. THIS WARRANT SHALL BE BINDING UPON ANY SUCCESSORS OR
        PERMITTED ASSIGNS OF THE COMPANY. THIS WARRANT WILL BE CONSTRUED AND
        ENFORCED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE COMMONWEALTH
        OF PENNSYLVANIA, EXCEPT FOR MATTERS ARISING UNDER THE SECURITIES ACT,
        WITHOUT REFERENCE TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF THE PARTIES
        CONSENTS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS
        SITTING IN THE COUNTY OF PHILADELPHIA IN THE COMMONWEALTH OF
        PENNSYLVANIA IN CONNECTION WITH ANY DISPUTE ARISING UNDER THIS WARRANT
        AND HEREBY WAIVES, TO THE MAXIMUM EXTENT PERMITTED BY LAW, ANY
        OBJECTION, INCLUDING ANY OBJECTION BASED ON FORUM NON CONVENIENS, TO THE
        BRINGING OF ANY SUCH PROCEEDING IN SUCH JURISDICTION. EACH PARTY HEREBY
        AGREES THAT IF THE OTHER PARTY TO THIS WARRANT OBTAINS A JUDGMENT
        AGAINST IT IN SUCH A PROCEEDING, THE PARTY WHICH OBTAINED SUCH JUDGMENT
        MAY ENFORCE SAME BY SUMMARY JUDGMENT IN THE COURTS OF ANY COUNTRY HAVING
        JURISDICTION OVER THE PARTY AGAINST WHOM SUCH JUDGMENT WAS OBTAINED, AND
        EACH PARTY HEREBY WAIVES ANY DEFENSES AVAILABLE TO IT UNDER LOCAL LAW
        AND AGREES TO THE ENFORCEMENT OF SUCH A JUDGMENT. EACH PARTY TO THIS
        WARRANT IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS IN ANY SUCH
        PROCEEDING BY THE MAILING OF COPIES THEREOF BY REGISTERED OR CERTIFIED
        MAIL, POSTAGE PREPAID, TO SUCH PARTY AT ITS ADDRESS IN ACCORDANCE WITH
        SECTION 12(C). NOTHING HEREIN SHALL AFFECT THE RIGHT OF ANY PARTY TO
        SERVE PROCESS N ANY OTHER MANNER PERMITTED BY LAW. EACH PARTY WAIVES ITS
        RIGHT TO A TRIAL BY JURY;

        (b)  Modification and Waiver. This Warrant and any provisions hereof may
        be changed, waived, discharged or terminated only with the written
        approval of the Holder. Any amendment effected in accordance with this
        paragraph shall be binding upon the Holder, each future holder of this
        Warrant and the Company. No waivers of, or exceptions to, any term,
        condition or provision of this Warrant, in any one or more instances,
        shall be deemed to be, or construed as, a further or continuing waiver
        of any such, term, condition or provision at any other time.

        (c)  Notices. Any notice, request or other document required or
        permitted to be given or delivered to the Holder or future holders
        hereof or the Company shall be personally delivered or facsimiled or
        shall be sent by reputable overnight courier or certified or registered
        mail, postage prepaid, to the Holder at its address as shown on the
        books of the Company or to the Company at the address set forth in the
        Purchase Agreement. All

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        notices under this Warrant shall be deemed to have been given (i) in the
        case of personal or facsimile delivery, on the date of such delivery,
        (ii) in the case of mailing, when received and (iii) in the case of
        overnight courier, upon receipt. A party may from time to time change
        the address to which notices to it are to be delivered or mailed
        hereunder by notice delivered in accordance with the provisions of this
        Section 12(c).

        (d)  Severability. Whenever possible, each provision of this Warrant
        shall be interpreted in such manner as to be effective and valid under
        applicable law, but if any provision of this Warrant is held to be
        invalid, illegal or unenforceable in any respect under any applicable
        law or rule in any jurisdiction, such invalidity, illegality or
        unenforceability shall not affect the validity, legality or
        enforceability of any other provision of this Warrant in such
        jurisdiction or affect the validity, legality or enforceability of any
        provision in any other jurisdiction, but this Warrant shall be reformed,
        construed and enforced in such jurisdiction as if such invalid, illegal
        or unenforceable provision had never been contained herein.

        (e)  No Impairment. The Company shall not, by amendment of its Charter
        or through any reorganization, transfer of assets, consolidation,
        merger, dissolution, issuance or sale of securities or any other
        voluntary action, avoid or seek to avoid the observance or performance
        of any of the terms of this Warrant, but shall at all times in good
        faith assist in the carrying out of all such terms and in the taking of
        all such action as may be necessary or appropriate in order to protect
        the rights of the Holder granted hereunder against impairment. Without
        limiting the generality of the foregoing, the Company (a) shall not
        increase the par value of shares of Common Stock above the amount
        payable therefor on such exercise, and (b) shall take all such action as
        may be reasonably necessary or appropriate in order that the Company may
        validly and legally issue fully paid and nonassessable Warrant Shares on
        the exercise of this Warrant. Notwithstanding the foregoing, nothing in
        this paragraph (e) or elsewhere in this Warrant shall limit or otherwise
        affect the power or right of the Company to engage in a reorganization,
        transfer of assets, consolidation, merger, dissolution, issuance or sale
        of securities or any other voluntary action so long as provision is made
        for the Holder of this Warrant to receive hereunder when this Warrant is
        Exercised the same consideration received as a result of any such event
        by the holder of each Convertible Security when a Convertible Security
        Event occurs with respect such Convertible Security.

        (f)  Specific Performance. The Company acknowledges and agrees that
        irreparable damage would occur in the event that the Company fails to
        perform any of the provisions of this Warrant in accordance with its
        specific terms. It is accordingly agreed that the Holder shall be
        entitled to seek an injunction or injunctions to prevent or cure
        breaches of the provisions of this Warrant and to enforce specifically
        the terms and provisions hereof, this being in addition to any other
        remedy to which the Holder may be entitled at law or in equity.

                            [Signature Page Follows]

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        IN WITNESS WHEREOF, the Company has caused this Warrant to be duly
executed by its officers thereunto duly authorized.

Dated:________ __, 2002

                                CHROMAVISION MEDICAL SYSTEMS, INC.

                                By:    _______________________________________
                                Name:  Kevin C. O'Boyle
                                Title: Executive Vice President Operations and
                                       Chief Financial Officer

ATTEST:

Sign:__________________________
Print Name:

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                                    EXHIBIT A

                                 ASSIGNMENT FORM

       (To assign the foregoing Warrant, execute this form and supply the
      required information. Do not use this form to exercise the Warrant.)

FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto
____________________ the right represented by the attached Warrant to purchase
shares of Common Stock of CHROMAVISION MEDICAL SYSTEMS, INC. to which the
attached Warrant relates and appoints _______________ attorney to transfer said
right on the books of CHROMAVISION MEDICAL SYSTEMS, INC. with full power of
substitution in the premises.

Dated:

---------------------------

                                        --------------------------------------
                                        (Signature must conform in all respects
                                        to name of holder as specified on the
                                        face of the Warrant)

                                        --------------------------------------
                                        Address of Transferee

                                        --------------------------------------
                                        --------------------------------------

In the presence of:

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                                                                     EXHIBIT 4.3

                      AMENDMENT NO. 3 TO RIGHTS AGREEMENT

        This Amendment No. 3 to Rights Agreement (this "Amendment") is made and
entered into as of this 11th day of June, 2002 by and between ChromaVision
Medical Systems, Inc., a Delaware corporation (the "Company"), and Computershare
Investor Services LLC, a Delaware limited liability company, who has succeeded
to the rights and obligations of Harris Trust Company of California, a trust
company organized under the laws of the State of California, as Rights Agent
(the "Rights Agent"), and is effective immediately prior to the execution and
delivery of that certain Securities Purchase Agreement, dated as of June 13,
2002 between the Company, Safeguard Delaware, Inc., a Delaware corporation and
Safeguard Scientifics, Inc., a Delaware corporation (the "Securities Purchase
Agreement") but only if the Securities Purchase Agreement is executed and
delivered.

        The Company and the Rights Agent are parties to a Rights Agreement dated
as of February 10, 1999, as amended by certain Amendments to the Rights
Agreement dated as of June 21, 1999 and September 28, 2000, respectively
(collectively the "Rights Agreement"). The parties now desire to amend the
Rights Agreement on the terms set forth herein. All capitalized terms not
otherwise defined in this Amendment shall have the meanings set forth in the
Rights Agreement, and all inconsistencies between this Amendment and the Rights
Agreement shall be resolved in favor of this Amendment.

        1. Definition of 15% Stockholder. The definition of "15% Stockholder" in
Section 1 of the Rights Agreement is hereby amended to read in full as follows:

        "15% Stockholder" shall mean any Person that Beneficially Owns 15% or
more of the Voting Shares of the Company then outstanding; provided, however,
that the term "15% Stockholder" shall not include:

        (i) an Exempt Person;

        (ii) any Person that would not otherwise be a 15% Stockholder but for a
        reduction in the number of outstanding Voting Shares resulting from a
        stock repurchase program or other similar plan of the Company or from a
        self tender offer of the Company, which Plan or tender offer commenced
        on or after the date hereof; provided, however, that the term "15%
        Stockholder shall include such Person from and after the first date upon
        which (A) such Person, since the date of the commencement of such plan
        or tender offer, shall have acquired Beneficial Ownership of, in the
        aggregate, a number of Voting Shares of the Company equal to 1% or more
        of the Voting Shares of the Company then outstanding and (B) such
        Person, together with all Affiliates and Associates of such Person,
        shall Beneficially own 15% or more of the Voting Shares of the Company
        then outstanding;

        (iii) any Person that would not otherwise be a 15% Stockholder but for
        its Beneficial Ownership of Rights;

        (iv) any Person that is the Beneficial Owner of 15% or more of the
        outstanding Voting Shares of the Company as of February 10, 1999 and
        thereafter has continued to be the Beneficial Owner of at least 15% of
        the Voting Shares of the Company then outstanding; provided however,
        that the term "15% Stockholder" shall include such Persons from and
        after the first date upon which

                        (A) such person since February 10, 1999 shall have
                acquired, without the prior approval of the Board of Directors
                of the Company, Beneficial Ownership of additional Voting Shares
                excluding (y) up to 1,351,607 shares acquired and to be acquired
                by Safeguard Scientifics, Inc. in the aggregate from Technology
                Leaders, L.P., Technology Leaders Offshore C.V., Technology
                Leaders II L.P. and Technology Leaders II Offshore C.V. after
                February 10, 1999, and (z) shares and warrants to purchase
                shares to be acquired by Safeguard Delaware, Inc., a
                wholly-owned subsidiary of Safeguard Scientifics, Inc. from the
                Company, as approved by a the Board of Directors of the Company
                on September 27, 2000, and provided

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                        (B) such Person, together with all Affiliates and
                Associates of such Person shall Beneficially Own not more than
                40% of the Voting Shares of the Company then outstanding;

        (v) any Exempted Group; or

        (vi) either of Safeguard Delaware, Inc. or with respect to Safeguard
        Delaware, Inc., (a) any other Person that at such time directly or
        indirectly through one or more intermediaries Controls, or is Controlled
        by, or is under common Control with, Safeguard Delaware, Inc., (b) any
        Person beneficially owning or holding, directly or indirectly, 10% or
        more of any class of voting or equity interests of Safeguard Delaware,
        Inc. or any Subsidiary or any corporation of which Safeguard Delaware,
        Inc. and its Subsidiaries beneficially own or hold, in the aggregate,
        directly or indirectly, 10% or more of any class of voting or equity
        interests and (c) any Person who would otherwise become a 15%
        Stockholder as a result of any voting agreements, proxies or other
        voting arrangements with respect to the Common Stock and/or the Series D
        5% Cumulative Convertible Preferred Stock of the Company (the Series D
        Preferred Stock") between Safeguard Delaware, Inc. or any of its
        affiliates and any or all of the present holders of the Series D
        Preferred Stock, the officers of the Company or the directors of the
        Company relating to approval of the matters to be voted upon at the
        special meeting of stockholders to be held pursuant to the Securities
        Purchase Agreement, it being the intention of the Board of Directors by
        this Amendment that no Rights have been exercised or become exercisable
        in connection with the "Transaction Documents" (as defined in the
        Securities Purchase Agreement), the related Stock Purchase Agreement to
        be entered into by the Company, Safeguard Delaware, Inc. and the present
        holders of the Series D Preferred Stock or the transactions contemplated
        thereby or by the Securities Purchase Agreement, including without
        limitation any of the voting arrangements referred to above.

As used in this definition, "Control" means the possession, directly or
indirectly, of the power to direct or cause the direction of the management and
policies of a Person, whether through the ownership of voting securities, by
contract or otherwise.

In calculating the percentage of the outstanding Voting Shares that are
Beneficially Owned by a Person for purposes of this definition, Voting Shares
that are Beneficially Owned by such Person shall be deemed outstanding, and
Voting Shares that are not Beneficially owned by such Person and that are
subject to issuance upon the exercise or conversion of outstanding conversion
rights, exchange rights, warrants or options shall not be deemed outstanding.
Any determination made by the Board of Directors of the Company as to whether
any person is or is not a 15% Stockholder shall be conclusive and binding upon
all holders of Rights."

        2. Definition of Exempted Group. Section 1 of the Rights Agreement is
hereby amended to add the following definition:

        "Exempted Group" shall mean any group (as defined in Rule 13d-5
        promulgated under the Exchange Act as in effect on the date hereof)
        consisting of Safeguard Scientifics, Inc., its Affiliates and
        Associates, and incuVest LLC, a limited liability company and its
        Affiliates and Associates, but only so long as (i) Safeguard
        Scientifics, Inc. and its Affiliates and Associates Beneficially Own
        more than a majority of the Voting Shares of the Company Beneficially
        Owned in the aggregate by Safeguard Scientifics, Inc., its Affiliates
        and Associates, incuVest LLC and its Affiliates and Associates and (ii)
        Safeguard Scientifics, Inc., its Affiliates and Associates, incuVest LLC
        and its Affiliates and Associates do not Beneficially Own in the
        aggregate more than 45% of the Voting Shares of the Company then
        outstanding."

        3. Continued Effectiveness. Except as amended hereby, the Rights
Agreement shall remain in full force and effect.

        4. Counterparts. This Amendment may be executed in two or more
counterparts, each of which will be deemed an original and all of which together
will constitute one and the same document.

                                       2
<PAGE>

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                                       3
<PAGE>

        IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of the day and year first above written.

                                            CHROMAVISION MEDICAL SYSTEMS, INC.

Attest:

By: /s/ Allison Wlodyka                     By: /s/ Kevin C. O'Boyle
   -------------------------------             ---------------------------------
   Name: Allison Wlodyka                       Name: Kevin C. O'Boyle
   Title: Assistant Secretary                  Title: Senior Vice President of
                                                      Operations

Dated:  June 11, 2002                       Dated:  June 11, 2002

                                               COMPUTERSHARE INVESTOR
                                               SERVICES LLC

Attest:

By: /s/ Michael Goedecke                    By: /s/ John A. Castellanos
   -------------------------------             ---------------------------------
   Name: Michael Goedecke                      Name  John A. Castellanos
   Title: Business Development                 Title: Relationship Manager

                                       4

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