Document:

EX-4.3

 Exhibit 4.3 

 
  

ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# 

Ordinary Shares 
 PAR VALUE $0.00001 
 Ordinary Shares 

Ortho Clinical Diagnostics 
 ORTHO CLINICAL DIAGNOSTICS HOLDINGS PLC 

INCORPORATED UNDER THE LAWS OF ENGLAND AND WALES WITH COMPANY NUMBER 13084624 

THIS CERTIFIES THAT 
 MR. SAMPLE & MRS. SAMPLE & MR. SAMPLE &MRS. SAMPLE 
 is the owner of 
 ***ZERO HUNDRED THOUSAND ZERO
HUNDRED AND ZERO*** 
 SEE REVERSE FOR CERTAIN DEFINITIONS 

CUSIP XXXXX XX X 
 THIS CERTIFICATE IS TRANSFERABLE IN CITIES DESIGNATED BY THE TRANSFER AGENT, AVAILABLE ONLINE AT www.computershare.com 

FULLY-PAID SHARES OF ORDINARY SHARES OF 
 Ortho Clinical Diagnostics Holdings plc transferable in accordance with, and subject to, the Company’s articles of association on the books of the Company in person or by duly
authorized attorney upon surrender of this certificate properly endorsed. This certificate is not valid unless countersigned by the Transfer Agent and registered by the Registrar. 

Witness the facsimile signatures of its duly authorized officers. 

FACSIMILE SIGNATURE TO COME 
 Chief Executive Officer 
 FACSIMILE SIGNATURE TO
COME 
 Secretary 
 DATED DD-MMM-YYYY 
 COUNTERSIGNED AND REGISTERED: 
 COMPUTERSHARE TRUST
COMPANY, N.A. 
 TRANSFER AGENT AND REGISTRAR, 

By 
 AUTHORIZED SIGNATURE 
 Certificate Number

 ZQ00000000 
 Shares 
 * * 000000****************** 

* * * 000000***************** 
 **** 000000**************** 
 *****
000000*************** 
 ****** 000000************** 

Ortho Clinical Diagnostics 
 PO BOX 43004, Providence, RI 02940-3004 
 MR A
SAMPLE 
 DESIGNATION (IF ANY) 
 ADD 1 
 ADD 2 

ADD 3 
 ADD 4 
 CUSIP XXXXXX XX X 

Holder ID XXXXXXXXXX 
 Insurance Value 1,000,000.00 
 Number of Shares
123456 
 DTC 12345678 123456789012345 
 Certificate Numbers 
 1234567890/1234567890

 1234567890/1234567890 
 1234567890/1234567890 
 1234567890/1234567890

 1234567890/1234567890 
 1234567890/1234567890 
 Total Transaction

 Num/No. 
 1 
 2 

3 
 4 
 5 

6 
 Denom. 
 1 

2 
 3 
 4 

5 
 6 
 Total 

1 
 2 
 3 

4 
 5 
 6 

 

 
  
 ORTHO
CLINICAL DIAGNOSTICS HOLDINGS PLC 
 A FULL STATEMENT OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE,
PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF SHARES OF THE COMPANY OR SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND/OR RIGHTS WILL BE FURNISHED BY THE COMPANY WITHOUT CHARGE TO ANY
SHAREHOLDER WHO SO REQUESTS UPON APPLICATION TO THE TRANSFER AGENT NAMED ON THE FACE HEREOF OR TO THE OFFICE OF THE SECRETARY OF THE COMPANY. THE TRANSFER OF THESE SHARES REPRESENTED BY THIS CERTIFICATE REQUIRES THE COMPLETION OF A SPECIALIZED STOCK
TRANSFER FORM AND MAY BE SUBJECT TO THE UNITED KINGDOM’S HM REVENUE AND CUSTOMS STAMP DUTY. PLEASE CONTACT THE TRANSFER AGENT FOR ADDITIONAL INFORMATION. 
 For US purposes the following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to
applicable laws or regulations: 
 TEN COM - as tenants in common

 TEN ENT - as tenants by the entireties 

JT TEN- as joint tenants with right of survivorship and not as tenants in common

 UNIF GIFT MIN ACT - Custodian 
 (Cust) (Minor) 
 under Uniform Gifts to Minors Act

 (State) 
 UNIF TRF MIN ACT - Custodian (until age ) 
 (Cust) 
 under Uniform Transfers to Minors Act

 (Minor) (State) 
 Additional abbreviations may also be used though not in the above list. 
 The IRS requires that the named transfer agent (“we”) report the cost basis of certain shares or units acquired after January 1, 2011. If your shares or units are covered by
the legislation, and you requested to sell or transfer the shares or units using a specific cost basis calculation method, then we have processed as you requested. If you did not specify a cost basis calculation method, then we have defaulted to the
first in, first out (FIFO) method. Please consult your tax advisor if you need additional information about cost basis. 
 If you do not keep in contact with the issuer or do not have any activity in your account for the time period specified by state law, your property may become subject to state unclaimed
property laws and transferred to the appropriate state.EX-10.3

 Exhibit 10.3 

SHAREHOLDERS AGREEMENT 
 OF 

ORTHO CLINICAL DIAGNOSTICS HOLDINGS PLC 

This Shareholders Agreement (“Agreement”) is entered into as of this     th day of
                , 2021, by and among Ortho Clinical Diagnostics Holdings plc, a public limited company incorporated and registered in England and Wales (the
“Company”), Carlyle Partners VI Cayman Holdings, L.P., a Cayman Islands exempted limited partnership (the “Initial Carlyle Shareholder”) and certain consultants and their affiliated entities and members of
management of the Company and/or its Subsidiaries that are parties hereto and that hold, or may hereafter be issued, Shares (each such Person, in its, his or her capacity as the holder of such Shares, collectively the “Management
Shareholders”). The names of the Management Shareholders as of the date hereof are set forth on Schedule I. Certain capitalized terms used herein without definition have the meanings ascribed to them in Section 6 hereof.

 RECITALS: 
 WHEREAS,
substantially concurrently with the execution of this Agreement, the Initial Carlyle Shareholder and the Management Shareholders signatory hereto have exchanged (the “Exchange”) ordinary shares, par value USD $0.00001 per share
(“Ortho Bermuda Shares”), in Ortho-Clinical Diagnostics Bermuda Co. Ltd. (“Ortho Bermuda” and wholly-owned Subsidiary of the Company) for a number of ordinary shares of nominal value USD $0.00001 per share in the
Company (“Shares”); 
 WHEREAS, the Parties are party to that certain Stockholders Agreement of Ortho Bermuda, dated as of
June 25, 2014 (the “Original Agreement”) and, in connection with the Exchange, the Parties are amending and restating the Original Agreement in the form of this Agreement; 

WHEREAS, Company has issued (or may hereafter issue) and, prior to the Exchange, Ortho Bermuda has issued, to the Management Shareholders
(i) Shares and/or Ortho Bermuda Shares pursuant to one or more subscription agreements (the “Subscription Agreements”) and/or (ii) options, warrants or other rights to subscribe for or purchase Shares or Bermuda Shares
(“Options”), pursuant to one or more option grant agreements (the “Option Agreements”), in each case adopted by the board of directors of the Company (the “Board of Directors”) or Ortho Bermuda;

 WHEREAS, as a result of the Exchange, the Initial Carlyle Shareholder and the Management Shareholders hold, as of the date hereof, the
number of Shares set forth on Schedule I; 
 WHEREAS, in connection with the Exchange, the Company, the Initial Carlyle Shareholder
and the Management Shareholders are executing this Agreement; and 
 WHEREAS, the Parties hereto desire to promote the interests of the
Company and the mutual interests of the Shareholders by establishing herein certain terms and conditions upon which the Shares will be held, including provisions restricting the transfer of such, and providing for other matters. 

 AGREEMENT: 

NOW, THEREFORE, in consideration of the foregoing and the mutual agreements set forth herein, and other good and valuable consideration, the
receipt and adequacy of which is hereby acknowledged, the Parties hereto, intending to be legally bound, hereby agree as follows: 
 Section 1.
Restrictions on Transfer. 
 Except for any Permitted Transfer (as defined below), no Management Shareholder shall Transfer any Shares
without the prior written approval of the Board of Directors of the Company; provided, however, that, following the 180th day after the consummation of the initial public offering of
Shares by the Company (the “IPO”), (a) any Current Management Shareholder (other than any Section 16 Shareholder) may, without the approval of the Board of Directors of the Company otherwise required by this sentence,
(i) in calendar year 2021, Transfer up to a maximum aggregate number of Shares equal to 50% of such Current Management Shareholder’s Total Vested Share Amount and (ii) following calendar year 2021, Transfer any Shares held by such
Current Management Shareholder, (b) any Section 16 Shareholder (other than a Smith Shareholder) may, without the approval of the Board of Directors of the Company otherwise required by this sentence, (i) in calendar year 2021,
Transfer up to a maximum aggregate number of Shares equal to 25% (or, if the Minimum Price Condition applies at such time, 10%) of such Section 16 Shareholder’s Total Share Amount, (ii) after calendar year 2021, Transfer up to a
maximum aggregate number of Shares equal to the excess of (A) 60% (or, if the Minimum Price Condition applies at such time, 25%) of such Section 16 Shareholder’s Total Share Amount over (B) the number of Shares Transferred by such
Section 16 Shareholder in 2021 and (iii) after calendar year 2022, Transfer any Shares issued to such Section 16 Shareholder upon the exercise of stock option awards granted under the Ortho-Clinical Diagnostics Bermuda Co. Ltd. 2014
Equity Incentive Plan prior to December 1, 2019, (c) any Smith Shareholder may, without the approval of the Board of Directors of the Company otherwise required by this sentence, (i) in calendar year 2021, Transfer up to a maximum
aggregate number of Shares equal to 10% (or, if the Minimum Price Condition applies at such time, 5%) of such Smith Shareholder’s Total Share Amount, and (ii) after calendar year 2021, Transfer up to a maximum aggregate number of Shares
equal to the excess of (A) 25% (or, if the Minimum Price Condition applies at such time, 12.5%) of such Smith Shareholder’s Total Share Amount over (B) the number of Shares Transferred by such Smith Shareholder in 2021, (d) any Former ELT
Shareholder may, without the approval of the Board of Directors of the Company otherwise required by this sentence, Transfer up to a maximum aggregate number of Shares equal to the product of (i) the Carlyle Sale Percentage (determined as of
the date that is 60 days prior to the applicable Transfer by such Former ELT Shareholder) and (ii) such Former ELT Shareholder’s Total Share Amount and (e) any Former Employee Shareholder may, without the approval of the Board of
Directors of the Company otherwise required by this sentence, (i) in calendar year 2021, Transfer up to a maximum aggregate number of Shares equal to 33% of such 

  
 2 

 
Former Employee Shareholder’s Total Share Amount and (ii) following calendar year 2021, Transfer any Shares held by such Former Employee Shareholder. Each Management Shareholder further
agrees that in connection with any Transfer permitted hereby, such Management Shareholder shall, if requested by the Company, deliver to the Company an opinion of counsel, in form and substance reasonably satisfactory to the Company and counsel for
the Company, to the effect that such Transfer is not in violation of this Agreement, the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder (the “Securities Act”), or the securities laws of any
state. It shall be a condition to any Permitted Transfer, or (prior to the IPO) any Transfer by any Management Shareholder approved by the Board of Directors of the Company, that (x) except to the extent waived in writing by the Company, the
Management Shareholder give the Company at least twenty (20) days’ prior written notice of such Permitted Transferee and (y) the transferee shall (i) agree to become a Party to this Agreement as a “Management
Shareholder”, (ii) execute a signature page in the form attached as Exhibit A hereto (each, a “Joinder Agreement”) acknowledging that such transferee agrees to be bound by the terms hereof, (iii) in the case of a
Permitted Transfer pursuant to clause (a) of the definition of “Permitted Transfer”, grant the transferring Management Shareholder an irrevocable proxy to vote such Shares, (iv) if such transferee is a natural person and a
resident of a state or other jurisdiction with a community or marital property system, cause such transferee’s spouse, if any, to execute and deliver to the Company a spousal consent in the form attached as Exhibit B hereto. The
Management Shareholder shall give the Company prompt notice of any actual Permitted Transfer. The Company shall not be required to (a) transfer on its books any Shares which have been Transferred in violation of any of the provisions of this
Agreement or (b) treat as owner of such Shares or to accord the right to vote as such owner or to pay dividends to any transferee to whom such Shares shall have been so Transferred. Any purported Transfer in violation of the provisions of
Section 1 shall be null and void and shall have no force or effect. For the avoidance of doubt, no Shares that are not vested (and no Shares issuable upon the exercise of Options, until issued upon the exercise of vested
Options) may be transferred pursuant to the exemptions described in this Section 1. For the avoidance of doubt, the restrictions set forth in this Section 1 apply, mutatis mutandis, to depositary receipts (or similar instruments)
representing interests in Shares. 
 Section 2. Permitted Transfers. 

Notwithstanding anything herein to the contrary, the restrictions and rights set forth in the first sentence of
Section 1 shall not apply to: (a) any Transfer of Shares by a Management Shareholder that is an individual by gift to, or for the benefit of, any member or members of his or her immediate family (which shall include
any spouse, lineal ancestor or descendant or sibling) or to a trust, partnership or limited liability company for the benefit of such family members; provided, however, that such Management Shareholder shall retain sole and exclusive
control over the voting and disposition of such Shares until the termination of this Agreement; (b) any Transfer of Shares by a Management Shareholder that is an individual to the heirs, executors or legatees of such Management Shareholder by
operation of law upon the death or incapacity of such Management Shareholder; or (c) any Transfer of Shares by a Management Shareholder that is not an individual to any Affiliate of such Management Shareholder (each of the Transfers referenced
in clauses (a), (b) and (c) above being referred to herein as a “Permitted  

  
 3 

 
Transfer”); provided, however, that, in each case, such Transfer is effected in compliance with all of the provisions of Section 1 hereof
(other than the restrictions contained in the first sentence of Section 1 hereof). The recipient of any Shares pursuant to the foregoing shall be referred to herein as a “Permitted Transferee” and shall be
deemed a “Management Shareholder” for all purposes of this Agreement. 
 Section 3.    Affiliate Transactions.

 The Management Shareholders acknowledge and approve the Amended and Restated Consulting Services Agreement, dated as of October 15,
2020, between Ortho-Clinical Diagnostics, Inc. and Carlyle Investment Management L.L.C., and the fees to be paid to Carlyle Investment Management, L.L.C. thereunder. 

Section 4. Termination. 
 This
Agreement, and the respective rights and obligations of the Parties, shall terminate upon the earlier of (a) the consummation of a Company Sale, unless the Management Shareholders will receive or return securities in such Company Sale and the
Board of Directors determines that this Agreement should remain in effect with respect to such securities following such transaction and (b) a written election to terminate this Agreement executed by the Carlyle Shareholders holding a majority
of the Shares then held by all Carlyle Shareholders. 
 Section 5. Certain Definitions. 

(a)    As used in this Agreement, the following terms shall have the meanings set forth below. 

“Affiliate” means, with respect to any Person, any Person directly or indirectly controlling, controlled by or under common
control with such Person. For purposes of this definition, “control” (and its derivatives) means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a Person, whether by
contract, through the ownership of voting securities, as trustee or executor, or otherwise. 
 “Carlyle Sale Percentage”
means, as of any date, that fraction (expressed as a percentage) the numerator of which is the aggregate number of Shares Transferred by the Carlyle Shareholders during the period beginning on January 1, 2021 and ending on such date, and the
denominator of which is the aggregate Total Share Amount of the Carlyle Shareholders. 
 “Carlyle Shareholders” means
(i) the Initial Carlyle Shareholder, (ii) any Affiliate of the Initial Carlyle Shareholder that is issued any Shares or Options after the date hereof and (iii) any subsequent transferee of the Shares or Options held by the Persons
listed in clause (i) or clause (ii) above. 
 “Closing Price” means, for any day, the price determined by the
first of the following clauses that applies: (i) if the Shares are then listed or quoted on the New York Stock Exchange or the Nasdaq Stock Market (each an “Approved Market”), the last sale price of the

  
 4 

 
Shares for such date (or the nearest preceding date) on the primary Approved Market on which the Shares are then listed or quoted as reported by Bloomberg Financial L.P.; and (ii) in all
other cases, the fair market value of a Share as determined by the Board of Directors and the Carlyle Shareholders in good faith. 

“Company Sale” means the consummation of any transaction or series of transactions (including, without limitation, any
merger, recapitalization, reorganization, sale of stock or other similar transaction) pursuant to which one or more Persons or group of Persons (other than the Initial Carlyle Shareholder) acquires (i) shares of the Company possessing the
voting power sufficient to elect a majority of the members of the Board of Directors or the board of directors of the successor to the Company (whether such transaction is effected by amalgamation, merger, consolidation, recapitalization, sale or
transfer of the Company’s shares or otherwise) or (ii) all or substantially all of the assets of the Company and its Subsidiaries. 

“Current Management Shareholder” means, as of any date, (i) Christopher Smith and any other Management Shareholder that
is a director, manager, officer or employee of the Company or any of its Subsidiaries as of the close of business on the 180th day after the consummation of the IPO (excluding, in each case in
this clause (i), with respect to any Transfer following calendar year 2022, any Management Shareholder who, at the time of such Transfer, is not a director, manager, officer or employee of the Company or any of its Subsidiaries) and (ii) any
other Management Shareholder solely (in the case of this clause (ii)) with respect to any Shares that were (A) Transferred to such Management Shareholder pursuant to one or more Permitted Transfers and (B) previously held by (or issued
upon the exercise of Options held by) an individual who, as of such date, is a Current Management Shareholder. 
 “Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder. 

“Former ELT Shareholder” means (i) each of GST Exempt Separate Family Trust c/u the Martin D. Madaus 2012 Irrevocable
Trusts, Charles F. Wagner, Jr. and the Alexander Antonio Socarras Revocable Trust and (ii) any other Management Shareholder solely (in the case of this clause (ii)) with respect to any Shares that were (A) Transferred to such Management
Shareholder pursuant to one or more Permitted Transfers and (B) previously held by (or issued upon the exercise of Options held by) a Management Shareholder named in clause (i). 

“Former Employee Shareholder” means, as of any date and with respect to the applicable Shares to be transferred, any
Management Shareholder that is neither a Current Management Shareholder nor a Former ELT Shareholder. 
 “Minimum Price
Condition” means that (and is considered to apply if), on the date of a Transfer, the Closing Price has been less than 75% of the public offering price of the Shares as set forth on the cover of the prospectus related to the IPO on twenty
or more of the thirty days immediately prior to such date. 
 “Party” means any of the parties to this Agreement. 

  
 5 

 “Person” means any individual, corporation, partnership, limited
partnership, limited liability company, syndicate, trust, association or other entity. 
 “SEC” means the United States Securities
and Exchange Commission. 
 “Section 16 Shareholder” means (i) any Current Management Shareholder
who (A) as of the 180th day after consummation of the IPO, would be required to file a report with the SEC pursuant to Section 16 of the Exchange Act with respect to a Transfer of Shares
on such date (whether or not such Current Management Shareholder continues to be required to file such reports at the time of a Transfer) or (B) with respect to any Transfer of Shares, would be required to file a report with the SEC pursuant to
Section 16 of the Exchange Act, and (ii) any other Management Shareholder solely (in the case of this clause (ii)) with respect to any Shares that were (A) Transferred to such Management Shareholder pursuant to one or more Permitted
Transfers and (B) previously held by (or issued upon the exercise of Options held by) an individual who, as of such date, is a Section 16 Shareholder. 

“Subsidiary” of any Person means any other Person (i) of which such first Person (either alone or through or together
with any other Subsidiary) owns, directly or indirectly, more than fifty percent (50%) of the stock or other equity securities of such other Person, the holders of which are generally entitled to vote for the election of the board of directors or
other governing body of, or otherwise control the business and affairs of, such other Person or (ii) the operations of which are consolidated with such first Person, pursuant to United States General Accepted Accounting Principles, for
financial reporting purposes. 
 “Shareholders” means the Carlyle Shareholders and the Management Shareholders. 

“Smith Shareholder” means, so long as Christopher Smith is a Current Management Shareholder (whether or not he continues to
be the Chief Executive Officer of the Company), (i) Christopher Smith and (ii) any other Management Shareholder solely (in the case of this clause (ii)) with respect to any Shares that were (A) Transferred to such Management Shareholder
pursuant to one or more Permitted Transfers and (B) previously held by (or issued upon the exercise of Options held by) Mr. Smith. 

“Total Share Amount” means, with respect to any Shareholder, the sum of (i) the number of Shares held or beneficially
owned by such Shareholder on January 1, 2021 (in the case of Transfers in 2021) or on January 1, 2022 (in the case of Transfers after 2021), (ii) the number of Shares that would be issued upon the exercise, as of such date, of all Options
held by such Shareholder on January 1, 2021 (in the case of Transfers in 2021) or on January 1, 2022 (in the case of Transfers after 2021) and (iii) in the case of Transfers after 2021, the number of Shares Transferred by such
Shareholder in 2021 following the 180th day after consummation of the IPO. 

“Total Vested Share Amount” means, with respect to any Current Management Shareholder, the sum of (i) the number of
vested Shares held or beneficially owned by such Current Management Shareholder on the 180th day after consummation of the IPO and (ii) the 

  
 6 

 
number of Shares that would be issued upon the exercise, as of such date, of all vested Options held by such Current Management Shareholder on the
180th day after consummation of the IPO. 
 “Transfer” means any
direct or indirect sale, transfer, assignment, conveyance, pledge or other encumbrance or disposition. 
 (b)    The
following terms have the meaning set forth in the Sections set forth below: 
  

			
	 Defined Term
	  	Location of Definition
	Agreement	  	Preamble
	Board of Directors	  	Recitals
	Company	  	Preamble
	Exchange	  	Recitals
	Initial Carlyle Shareholder	  	Preamble
	Management Shareholder	  	Preamble
	Option Agreements	  	Recitals
	Ortho Bermuda	  	Recitals
	Ortho Bermuda Shares	  	Recitals
	Permitted Transfer	  	Section 2
	Permitted Transferee	  	Section 2
	Securities Act	  	Section 1
	Shares	  	Recitals
	Subscription Agreements	  	Recitals

 Section 6. Miscellaneous. 

(a)    Legends. Each certificate representing the securities issued by the Company and held by a Shareholder shall
bear the following legends: 
 “THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), AND ARE “RESTRICTED SECURITIES” AS THAT TERM IS DEFINED IN RULE 144 UNDER THE ACT. THESE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED EXCEPT (I) PURSUANT TO AN
EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT, OR (II) UNLESS THE ISSUER HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO IT THAT THESE SECURITIES MAY BE SOLD PURSUANT TO RULE 144 OR ANOTHER AVAILABLE EXEMPTION UNDER THE ACT AND THE RULES
AND REGULATIONS THEREUNDER.” 

  
 7 

 “THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFER SET FORTH IN THAT CERTAIN
SHAREHOLDERS’ AGREEMENT OF ORTHO CLINICAL DIAGNOSTICS HOLDINGS PLC, DATED AS OF JANUARY [ 🌑 ], 2021, A COPY OF WHICH MAY BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE
COMPANY.” 
 (b)    Successors, Assigns and Transferees. This Agreement shall be binding upon and inure to
the benefit of the Parties and their respective legal representatives, heirs, legatees, successors, and assigns and any other transferee and shall also apply to any securities acquired by a Shareholder after the date hereof. 

(c)    Governing Law. This Agreement shall be governed by, and construed in accordance with, the laws of the State
of Delaware. 
 (d)    Specific Performance; Submission to Jurisdiction. The Parties agree that irreparable
damage would occur in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the Parties shall be entitled to an injunction or
injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement in federal and state courts located in Wilmington, Delaware, USA, this being in addition to any other remedy to which such party
is entitled at law or in equity. In addition, each of the parties hereto (i) consents to submit itself to the personal jurisdiction of the federal and state courts located in Wilmington, Delaware in the event any dispute arises out of this
Agreement or any of the transactions contemplated by this Agreement; (ii) agrees that it will not attempt to deny or defeat such personal jurisdiction by motion or other request for leave from such court, (iii) agrees that it will not
bring any action relating to this Agreement or any of the transactions contemplated by this Agreement in any court other than the federal or state courts located in the Wilmington, Delaware, USA, and (iv) to the fullest extent permitted by Law,
consents to service being made through the notice procedures set forth in Section 6(f). Each party hereto hereby agrees that, to the fullest extent permitted by applicable law, service of any process, summons, notice or
document by U.S. registered mail to the respective addresses set forth in Section 6(f) shall be effective service of process for any suit or proceeding in connection with this Agreement or the transactions contemplated
hereby. 
 (e)    Interpretation. The headings of the Sections contained in this Agreement are solely for the
purpose of reference, are not part of the agreement of the Parties and shall not affect the meaning or interpretation of this Agreement. 

(f)    Notices. All notices and other communications provided for or permitted hereunder shall be in writing and
shall be deemed to have been duly given and received when delivered by overnight courier or hand delivery, when sent by telecopy, or five days after mailing if sent by registered or certified mail (return receipt requested) postage prepaid, to the
Parties at the following addresses (or at such other address for any Party as shall be specified by like notices). 

  
 8 

	 	(i)	 If to any Carlyle Shareholder, addressed to such Carlyle Shareholder, c/o The Carlyle Group, at:

 520 Madison Avenue 

42nd Floor 

New York, NY 10022 
 Attention:
Stephen H. Wise 
 Facsimile: (212) 893-4901 

With a copy to: 

Latham & Watkins LLP 

555 Eleventh Street, N.W. 

Suite 1000 
 Washington, D.C.
20004 
 Attention: Daniel T. Lennon 

                    David I. Brown 

Facsimile: (202) 637-2201 
  

	 	(ii)	 If to any Management Shareholder, to the address set forth on such Shareholder’s signature page hereto.

  

	 	(vi)	 If to the Company: 

c/o Ortho-Clinical Diagnostics, Inc. 

1001 Route 202 
 Raritan, NJ
08869 
 Attention: Michael A. Schlesinger 

Facsimile: (844) 892-5398 

With a copy to: 

Latham & Watkins LLP 

555 Eleventh Street, N.W. 

Suite 1000 
 Washington, D.C.
20004 
 Attention: Daniel T. Lennon 

                    David I. Brown 

Facsimile: (202) 637-2201 

(g)    Recapitalization, Exchange, Etc. Affecting the Company’s Shares. The provisions of this Agreement shall
apply, to the full extent set forth herein, with respect to any and all Shares and/or other classes of shares or equity securities of the Company or any successor 

  
 9 

 
or assign of the Company (whether by amalgamation, merger, consolidation, sale of assets, or otherwise) that may be issued in respect of, in exchange for, or in substitution of such Shares, and
shall be appropriately adjusted for any issue of bonus shares, splits, reverse splits, combinations, recapitalizations, and the like occurring after the date hereof. 

(h)    Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed to
be an original and all of which together shall be deemed to constitute one and the same agreement. 

(i)    Attorney’s Fees. In any action or proceeding brought to enforce any provision of this Agreement, the
successful Party shall be entitled to recover reasonable attorney’s fees and expenses in addition to any other available remedy. 

(j)    Severability. In the event that any one or more of the provisions contained herein, or the application
thereof in any circumstances, is held invalid, illegal, or unenforceable in any respect for any reason, the validity, legality, and enforceability of any such provision in every other respect and of the remaining provisions contained herein shall
not be in any way impaired thereby. 
 (k)    Amendment. Any provision of this Agreement may be amended and the
observance thereof may be waived (either generally or in a particular instance and either retroactively or prospectively), only by the written consent of the Company and the Carlyle Shareholders. Notwithstanding the foregoing, if any such amendment
or waiver would materially adversely affect the rights or obligations of the Management Shareholders, then such amendment or waiver shall require the prior written consent of the Management Shareholders holding a majority of the Shares then held by
all Management Shareholders. Any amendment or waiver effected in accordance with this Section 6(k) shall be binding upon the Company, the Carlyle Shareholders and their successors and assigns and the Management Shareholders
and their successors and assigns. At any time hereafter, additional Management Shareholders may be made parties hereto by executing a signature page in the form attached as Exhibit A hereto, which signature page shall be countersigned by the
Company and shall be attached to this Agreement and become a part hereof without any further action of any other Party hereto. Notwithstanding the foregoing, (i) effective on the date hereof, the Parties hereby amend and restate the Original
Agreement in the form hereof, (ii) the Parties acknowledge that the Exchange and the entry into this Agreement are in contemplation of the IPO and (iii) if the Carlyle Shareholders or the Company make a determination, each in their sole
discretion, to terminate or no longer pursue the IPO after the date hereof, the Company and the Carlyle Shareholders will be permitted to amend this Agreement to include provisions that are substantially comparable to Sections 2, 3, 5, 9(g) and 9(m)
of the Original Agreement. 
 (l)    Tax Withholding. The Company, the Carlyle Shareholders and any Third Party
Purchasers, as applicable, shall be entitled to require payment in cash or deduction from other compensation payable to any Shareholder of any sums required by federal, state, or local tax law to be withheld with respect to the issuance, vesting,
exercise, purchase, repurchase, or cancellation of any Share or any Option. Each Management Shareholder shall provide the 

  
 10 

 
Company with a properly completed and duly executed Internal Revenue Service Form W-9 or W-8, as appropriate, and
in each case any required supporting documentation, on the date hereof and from time to time thereafter promptly upon the obsolescence or invalidity of any such form previously delivered. 

(m)    Entire Agreement. This Agreement and (with respect to the Company) the Subscription Agreements and Option
Agreements (including, in each case, any and all exhibits, schedules and other instruments contemplated thereby) constitute the entire agreement of the Parties with respect to the subject matter hereof. 

[Remainder of Page Intentionally Left Blank.] 

  
 11 

 IN WITNESS WHEREOF, the Parties have executed this Agreement on the date first written
above. 
  

			
	ORTHO CLINICAL DIAGNOSTICS HOLDING PLC
		
	By:	 	             

	Name:	 	
	Title:	 	

 [Signature Page to Shareholders Agreement] 

 
			
	INITIAL CARLYLE SHAREHOLDER:
	
	CARLYLE PARTNERS VI CAYMAN HOLDINGS, L.P.
		
	By:	 	TC Group VI Cayman, L.P.
	Its:	 	General Partner
		
	By:	 	TC Group VI Cayman, L.L.C.
	Its:	 	General Partner
		
	By:	 	             

	Name:	 	
	Title:	 	Authorized Person

 [Signature Page to Shareholders Agreement] 

 
			
	 [MANAGEMENT SHAREHOLDER]

		
	 By:
	 	             

	 Name:
	 	
	 Title:
	 	

 [Signature Page to Shareholders Agreement] 

 EXHIBIT A 

SIGNATURE PAGE 
 TO 

SHAREHOLDERS AGREEMENT 
 By execution of this
signature page, [                    ] hereby agrees to become a Party to, and to be bound by the obligations of, and receive the benefits of, that
certain Shareholders Agreement, dated as of                 , 2021, by and among Ortho Clinical Diagnostics Holdings plc, a public limited company incorporation in
England and Wales, Carlyle Partners VI Cayman Holdings, L.P., a Cayman Islands exempted limited partnership, and certain other Parties named therein, as amended from time to time thereafter, in each case as a “Management Shareholder”. 

 

			
	By:	 	  

	Name:	 	
	Title:	 	
	
	Notice Address:
	
	  

	
	  

  

			
	Accepted:
	
	ORTHO CLINICAL DIAGNOSTICS HOLDINGS PLC
		
	By:	 	             

	Name:	 	
	Title:	 	

 EXHIBIT B 

SPOUSAL CONSENT 
 In
consideration of the execution of that certain Shareholders Agreement (as it may be amended from time to time in accordance with its terms, the “Shareholders Agreement”; capitalized terms used but not defined herein shall be given
the meaning ascribed to them in the Shareholders Agreement), dated as of June 30, 2014, by and among Ortho Clinical Diagnostics Holdings plc, a public limited company incorporation in England and Wales, Carlyle Partners VI Cayman Holdings,
L.P., a Cayman Islands exempted limited partnership, certain Management Shareholders, and any other Persons who become parties to the Shareholders Agreement pursuant to a Joinder Agreement, I,
                    , the spouse of
                    , who is a party to the Shareholders Agreement, do hereby join with my spouse in executing the foregoing Shareholders Agreement
and do hereby agree to be bound by all of the terms and provisions thereof. 
 Dated as of
                    , 20     
  

	
	          

	Name of Spouse:

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