Document:

Agreement with the 10X Fund L.P.

 Exhibit 10.1 
 10X FUND, L.P. 
 1099 Forest Lake Terrace

 Niceville, Florida 32578 
 February 11, 2010 
 Pro-Pharmaceuticals, Inc. 
 7 Wells Avenue 
 Newton, MA 02459 
  

	 	Re:	Securities Purchase Agreement dated February 12, 2009 (the “Securities Purchase Agreement”) by and between 10X Fund, L.P. (the “Fund”) and
Pro-Pharmaceuticals, Inc. (the “Company”), as amended on August 11, 2009 

 Dear Sirs: 
 I am writing to confirm that the Fund and the Company have agreed to the following in relation to the Securities Purchase Agreement: 
  

	 	(1)	the “Final Purchase Date” (as defined in the Securities Purchase Agreement) is hereby extended for three months and fourteen days, i.e., from
February 11, 2010 to May 25, 2010; and 

  

	 	(2)	The definition for “Series B-1 Redemption Date” contained in Section 1 of the Certificate of Designation of Preferences, Rights and Limitations for the
Series B-1 Convertible Preferred Stock (the “Certificate of Designation”) shall be amended to provide that such date will be twenty two months and fourteen days (22 months and 14 days) after the Original Issue Date of the Series B-1
Convertible Preferred Stock. 

  

	 	(3)	The definition for “Final Purchase Date” contained in Section 1 of the Certificate of Designation shall be amended to provide that is May 25, 2010.

  

	 	(4)	Section 3 of the Certificate of Designation shall be amended to provide that the Registration Statement Condition must only be true as to any dividends paid on or
after September 30, 2010. 

  

	 	(5)	The definition of “VWAP” contained in Section 1 of the Certificate of Designation shall be amended to correct certain errors in referring to possible
trading on the Pink Sheets. 

 In order to implement the agreements in Paragraph (2), (3) and (4) above, the Company
shall file the attached amendment to Certificate of Designation. This letter represents the entire agreement of the parties with respect to the subject matter of this letter. Nothing hereby shall be deemed to modify, amend, or waive any provision of
the Securities Purchase Agreement, or any documents or securities executed or issued pursuant thereto, except to the extent specifically stated herein. Please confirm that the Company has agreed to the terms set forth in this letter by executing and
returning a copy of this letter to me. 
  

			
	Very truly yours,
	
	10X FUND, L.P., a Delaware limited partnership
	
	 By: 10X CAPITAL MANAGEMENT, LLC, a Florida
 limited liability company

	
	 /s/ James C. Czirr

	By:	 	James C. Czirr, Manager

  

			
	ACCEPTED AND AGREED TO:
	
	PRO-PHARMACEUTICALS, INC.
	
	 /s/ Anthony D. Squeglia

	By:	 	Anthony D. Squeglia
	Its:	 	Chief Financial OfficerSupplemental Indenture, datd February 8, 2010

 Exhibit 4.9 
 SUPPLEMENTAL INDENTURE 
 SUPPLEMENTAL INDENTURE (this
“Supplemental Indenture”), dated as of February 8, 2010, among AutoNation, Inc., a Delaware corporation (the “Company”) and Auto Holding, LLC f/k/a Auto Holding Corp., AutoNation Financial Services, LLC f/k/a
AutoNation Financial Services Corp., AN Luxury Imports of Spokane, Inc., AN Collision Center of Tempe, Inc. f/k/a Pitre Isuzu-Subaru-Hyundai of Scottsdale, Inc. and AN Luxury Imports of Phoenix, Inc. f/k/a AN Luxury Imports of Spokane, Inc. (the
“Guaranteeing Subsidiaries”), which are indirect subsidiaries of the Company (or its permitted successor), and Wells Fargo Bank, National Association, as trustee under the Indenture referred to below (the
“Trustee”). 
 W I T N E S S E T H 
 WHEREAS, the Company, has heretofore executed and delivered to the Trustee an indenture, dated as of April 12, 2006, which has been
supplemented as of August 17, 2006, January 24, 2007, October 18, 2007, March 11, 2008, August 12, 2008 and February 6, 2009 (as amended, the “Indenture”), providing for the issuance of
Floating Rate Senior Notes due 2013 and 7% Senior Notes due 2014 (the “Notes”); 
 WHEREAS, the Indenture
provides that the Guaranteeing Subsidiaries shall execute and deliver to the Trustee a supplemental indenture pursuant to which the Guaranteeing Subsidiaries shall unconditionally guarantee all of the Company’s obligations under the Notes and
the Indenture on the terms and conditions set forth herein (the “Guarantee”); and 
 WHEREAS, pursuant to
Section 9.1 of the Indenture, the Trustee is authorized to execute and deliver this Supplemental Indenture. 
 NOW
THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the Company, the Guaranteeing Subsidiaries and the Trustee mutually covenant and agree for the equal and ratable
benefit of the Holders of the Notes as follows: 
 1. Capitalized Terms. Capitalized terms used herein without definition
shall have the meanings assigned to them in the Indenture. 
 2. Agreement to Guarantee. The Guaranteeing Subsidiaries
hereby agree as follows: 
  

	 	(a)	To jointly and severally Guarantee to each Holder of a Note authenticated and delivered by the Trustee and to the Trustee and its successors and assigns, irrespective
of the validity and enforceability of the Indenture, the Notes or the obligations of the Company hereunder or thereunder, that: 

  

	 	(i)	the principal of and interest on the Notes will be promptly paid by the Company in full when due, whether at maturity, by acceleration, redemption or otherwise, and
interest on the overdue principal of and interest on the Notes, if any, if lawful, and all other obligations of the Company to the Holders or the Trustee hereunder or thereunder will be promptly paid by the Company in full or performed by the
Company, all in accordance with the terms hereof and thereof; and 

  

	 	(ii)	in case of any extension of time of payment or renewal of any Notes or any of such other obligations, that same will be promptly paid by the Company in full when due or
performed by the Company in accordance with the terms of the extension or renewal, whether at stated maturity, by acceleration or otherwise. Failing payment when due by the Company of any amount so guaranteed or any performance so guaranteed which
failure continues for three days after demand therefor is made to the Company for whatever reason, the Guarantors shall be jointly and severally obligated to pay the same immediately. 

  

	 	(b)	The obligations hereunder shall be unconditional, irrespective of the validity, regularity or enforceability of the Notes or the Indenture, the absence of any action to
enforce the same, any waiver or consent by any Holder of the Notes with respect to any provisions hereof or thereof, the recovery of any judgment against the Company, any action to enforce the same or any other circumstance which might otherwise
constitute a legal or equitable discharge or defense of a Guarantor. 

	 	(c)	The following is hereby waived: diligence, presentment, demand of payment (except as specifically provided in (a) above), filing of claims with a court in the
event of insolvency or bankruptcy of the Company, any right to require a proceeding first against the Company, protest, notice and all demands (except as specifically provided in (a) above) whatsoever. 

  

	 	(d)	This Guarantee shall not be discharged except (i) by complete performance of the obligations contained in the Notes and the Indenture. Each Guarantor also
expressly waives, without any requirement of any notice to or further assent by such Guarantor, to the fullest extent permitted by applicable law, the benefit of all principles or provisions of applicable law which are or might be in conflict with
the terms hereof, including, without limitation, Section 10-7-23 and Section 10-7-24 of the Official Code of Georgia Annotated. 

  

	 	(e)	If any Holder or the Trustee is required by any court or otherwise to return to the Company, the Guarantors, or any Custodian, Trustee, liquidator or other similar
official acting in relation to either the Company or the Guarantors, any amount paid by either to the Trustee or such Holder, this Guarantee, to the extent theretofore discharged, shall be reinstated in full force and effect.

  

	 	(f)	The Guaranteeing Subsidiaries shall not be entitled to any right of subrogation in relation to the Holders in respect of any obligations guaranteed hereby until payment
in full of all obligations guaranteed hereby. 

  

	 	(g)	As between the Guarantors, on the one hand, and the Holders and the Trustee, on the other hand, (x) the maturity of the obligations guaranteed hereby may be
accelerated as provided in Article 6 of the Indenture for the purposes of this Guarantee, notwithstanding any stay, injunction or other prohibition preventing such acceleration in respect of the obligations guaranteed hereby, and (y) in the
event of any declaration of acceleration of such obligations as provided in Article 6 of the Indenture, such obligations (whether or not due and payable) shall forthwith become due and payable by the Guarantors for the purpose of this Guarantee,
failing payment when due by the Company which failure continues for three days after demand therefor is made to the Company. 

  

	 	(h)	The Guarantors shall have the right to seek contribution from any non-paying Guarantor so long as the exercise of such right does not impair the rights of the Holders
under the Guarantee. 

 3. Execution and Delivery. The Guaranteeing Subsidiaries agree that the Guarantees
shall remain in full force and effect notwithstanding any failure to endorse on each Note a notation of such Guarantee. 
 4.
Guaranteeing Subsidiaries May Consolidate, Etc. on Certain Terms. The Guaranteeing Subsidiaries agree that, unless the Guarantee is being currently released in conformity with Section 10.4 of the Indenture, it may not sell or otherwise
dispose of all or substantially all of its assets, or consolidate with or merge with or into (whether or not such Guaranteeing Subsidiaries are the surviving Person) another corporation, Person or entity whether or not affiliated with such
Guaranteeing Subsidiaries unless either (a) the Guaranteeing Subsidiaries will be the continuing corporation (in the case of a consolidation or merger involving the Guaranteeing Subsidiaries) or (b) the Person (if other than the
Guaranteeing Subsidiaries) formed by such consolidation or into which the Guaranteeing Subsidiaries are merged or the Person which acquires by sale, assignment, conveyance, transfer, lease or disposition of all or substantially all of the properties
and assets of the Guaranteeing Subsidiaries and its Restricted Subsidiaries on a Consolidated basis (the “Guaranteeing Subsidiaries Surviving Entity”) will be duly organized and validly existing under the laws of the United States
of America, any state thereof or the District of Columbia and such Person expressly assumes, by a supplemental indenture, in the form reasonably satisfactory to the Trustee, all the obligations of the Guaranteeing Subsidiaries under the Guarantee
and the Indenture and the Registration Rights Agreement, as the case may be, and the Guarantee and the Indenture and the Registration Rights Agreement will remain in full force and effect as so supplemented and at the time of the transaction the
Guaranteeing Subsidiaries or the Guaranteeing Subsidiaries Surviving Entity will have delivered, or caused to be delivered, to the Trustee, in form and substance reasonably satisfactory to the Trustee, an Officers’ Certificate and an Opinion of
Counsel, each to the effect that such consolidation, merger, transfer, sale, assignment, conveyance, transfer, lease or other transaction and the supplemental indenture in respect thereof comply with the Indenture and that all conditions precedent
therein provided for relating to such transaction have been complied with. 
  

 2 

 5. Releases. The Guarantee of the Guaranteeing Subsidiaries will be released in
accordance with the provisions set forth in the Indenture, including, without limitation, Section 10.4 of the Indenture. The Trustee will provide any written confirmation or evidence of the termination of such Guarantee as reasonably required
by the Company. Any Guarantor not released from its obligations under its Guarantee shall remain liable for the full amount of principal of and interest on the Notes and for the other obligations of any Guarantor under the Indenture as provided in
Article 10 of the Indenture. 
 6. No Recourse Against Others. No director, officer, employee, incorporator, stockholder
or agent of any of the Guaranteeing Subsidiaries, as such, shall have any liability for any obligations of the Company or the Guaranteeing Subsidiaries under the Notes, the Indenture, any Guarantees or this Supplemental Indenture or for any claim
based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. Such
waiver may not be effective to waive liabilities under the federal securities laws. 
 7. New York Law to Govern. THE
INTERNAL LAW OF THE STATE OF NEW YORK SHALL GOVERN AND BE USED TO CONSTRUE THIS SUPPLEMENTAL INDENTURE. 
 8.
Counterparts. The parties may sign any number of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 
 9. Effect of Headings. The Section headings herein are for convenience only and shall not affect the construction hereof. 

10. The Trustee. The Trustee shall not be responsible in any manner whatsoever for or in respect of the validity, legality or
sufficiency of this Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Guaranteeing Subsidiaries and the Company. 
 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed, all as of the date first above written.

  

			
	AUTONATION, INC.
		
	By:	 	 /s/ C. Coleman G. Edmunds

	Name:	 	C. Coleman G. Edmunds
	Title:	 	Sr. Vice President, Deputy General Counsel
	
	Auto Holding, LLC f/k/a Auto Holding Corp.,
	AutoNation Financial Services, LLC
	     f/k/a AutoNation Financial Services Corp.,

	AN Luxury Imports of Spokane, Inc.,
	AN Collision Center of Tempe, Inc.
	    f/k/a Pitre Isuzu-Subaru-Hyundai of Scottsdale, Inc.
	AN Luxury Imports of Phoenix, Inc.
	    f/k/a AN Luxury Imports of Spokane, Inc.
		
	By:	 	 /s/ C. Coleman G. Edmunds

	Name:	 	C. Coleman G. Edmunds
	Title:	 	Assistant Secretary

 [SIGNATURES
CONTINUE ON NEXT PAGE] 
  

 3 

			
	 Wells Fargo Bank, National Association,
 As Trustee

		
	By:	 	 /s/ Raymond Delli Colli

	Name:	 	Raymond Delli Colli
	Title:	 	Vice President

  

 4

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00168-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00168-of-00352.parquet"}]]