Document:

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                                                                    EXHIBIT 10.8

November 3, 2003

Stephen C. Farrell
8 Minute Man Lane
Lexington, MA   02421

                 Re: Amendment to Executive Retention Agreement

Dear Steve,

This letter agreement serves to amend the Executive Retention Agreement dated as
of March 7, 2002, by and between you and PolyMedica Corporation (the "Company").

1.       Section 2 Term of Agreement. The definition of "Term" is hereby amended
as follows:

                  "'Term' shall mean the period commencing as of the Effective
         Date and continuing in effect through August 31, 2004; provided,
         however, that commencing on September 1, 2004 and each September 1
         thereafter, the Term shall be automatically extended for one additional
         year unless, not later than 90 days prior to the scheduled expiration
         of the Term (or any extension thereof), the Company shall have given
         the Executive written notice that the Term will not be extended."

2.       Section 4.2(a)(i)(2) Compensation is hereby deleted in its entirety and
replaced with the following in lieu thereof:

                 "(2) the amount equal to (A) two multiplied by (B) the sum of
         (x) the Executive's highest annual base salary during the three-year
         period prior to the Change in Control Date and (y) the Executive's
         highest annual bonus during the three-year period prior to the Change
         in Control Date."

If the foregoing is acceptable to you, please indicate your agreement by signing
a copy of this letter agreement and returning it to the undersigned.

                                             Very truly yours,

                                             /s/ Samuel L. Shanaman
                                             ----------------------
                                             Samuel L. Shanaman
                                             Lead Director and Interim Chief
                                               Executive Officer

ACCEPTED AND AGREED TO:

/s/ Stephen C. Farrell
----------------------
Stephen C. Farrell

November 3, 2003
-----------------
Date<PAGE>

                                                                    EXHIBIT 10.9

November 3, 2003

Stephen C. Farrell
8 Minute Man Lane
Lexington, MA   02421

                      Re: Amendment to Employment Agreement

Dear Steve,

This letter agreement serves to further amend the Employment Agreement dated as
of September 1, 2000, by and between you and PolyMedica Corporation (the
"Company"), as amended by certain letter agreements dated as of April 16, 2001;
September 24, 2001; October 12, 2001; May 31, 2002; July 15, 2002; February 5,
2003 and August 29, 2003 (together, the "Employment Agreement").

1.       Section 3.6 Severance Pay is hereby deleted in its entirety and
replaced with the following in lieu thereof:

                "3.6 Severance Pay. If at any time during the term of this
         Agreement (including any Extended Employment Period), the Executive's
         employment is terminated by the Company without cause (i.e. other than
         pursuant to Section 3.5 or Section 4 hereof), and subject to the
         Executive's execution and non-revocation of a severance agreement and
         release drafted by and satisfactory to counsel for the Company, the
         Company shall continue to pay Executive at his then current Base Salary
         for the remainder of the Employment Period or for eighteen months,
         whichever is longer (the "Severance Period"). Neither party shall be
         entitled to any compensation or claim for good will or other loss
         suffered by reason of termination of this Agreement. Notwithstanding
         the foregoing, the Company's obligations under this Section 3.6 shall
         cease immediately upon the payment by the Company to the Executive of
         the lump sum payment described in Section 4.2(a)(i) of the Executive
         Retention Agreement dated as of March 7, 2002, as may be amended from
         time to time, by and between the Company and the Executive."

2.       Section 3.7 Benefits During Severance Period is hereby deleted in its
entirety and replaced with the following in lieu thereof:

                "3.7 Benefits During Severance Period. Except as otherwise
         required by law, the Executive shall not be entitled to any employee
         benefits provided under Section 3.3 after termination of Executive's
         employment whether or not severance pay is being provided, except that
         if severance pay is being provided (i) the Company shall continue in
         full force and effect, at its expense, the life insurance provided for
         in Section 3.3(b) for a period of eighteen (18) months after
         termination of Executive's employment hereunder or until Executive
         becomes employed, whichever first occurs, and (ii) the Company shall
         offer, at

<PAGE>

         its expense, continued health and dental insurance as required under
         the Consolidated Omnibus Budget Reconciliation Act of 1985 ("COBRA") or
         other law for a period of eighteen (18) months after termination of
         Executive's employment hereunder or until Executive becomes employed,
         whichever first occurs. If Executive elects not to maintain health
         insurance pursuant to COBRA or other law, the Company is under no
         obligation to reimburse Executive for his otherwise elected coverage.
         Executive shall be obligated to give the Company prompt notice of his
         subsequent employment and at that time, the Company's obligations
         pursuant to this Section 3.7, if any, shall cease."

If the foregoing is acceptable to you, please indicate your agreement by signing
a copy of this letter agreement and returning it to the undersigned.

                                                 Very truly yours,

                                                 /s/ Samuel L. Shanaman
                                                 ----------------------
                                                 Samuel L. Shanaman
                                                 Lead Director and
                                                 Interim Chief Executive Officer

ACCEPTED AND AGREED TO:

/s/ Stephen C. Farrell
----------------------
Stephen C. Farrell

November 3, 2003
-----------------
Date

                                       2<PAGE>

                                                                   EXHIBIT 10.10

                              LETTER OF RESIGNATION

I, Arthur A. Siciliano, Ph.D., hereby resign as President of PolyMedica
Corporation; President and Secretary of PolyMedica Holdings, Inc.; President and
Director of PolyMedica Securities, Inc.; President and Director of PolyMedica
Healthcare, Inc.; President and Director of PolyMedica Pharmaceuticals (U.S.A.),
Inc.; Director of PolyMedica Pharmaceuticals (Puerto Rico), Inc.; President and
Director of PolyMedica Pharmaceuticals Securities, Inc.; Director of Liberty
Medical Supply, Inc.; Director of Liberty Home Pharmacy Corporation; Director of
Liberty Therapeutic Shoe Corporation; President, Secretary and Director of
Liberty Medical Supply LLC; President, Secretary and Director and Liberty Home
Pharmacy LLC; President and Director of Liberty Lane Development Company, Inc.;
Director of Liberty Lane Condominium Association, Inc.; as well as any other
unnamed positions that I may hold in any affiliate or subsidiary of PolyMedica
Corporation effective the close of business on November 5, 2003.

November 5, 2003                                  /s/ Arthur A. Siciliano, Ph.D.
----------------                                  ------------------------------
Date                                                  Arthur A. Siciliano, Ph.D.<PAGE>

                                                                   EXHIBIT 10.11

November 5, 2003

Arthur A. Siciliano, Ph.D
13 Salt Marsh Lane
Gloucester, MA 01930

                 Re: Amendment to Executive Retention Agreement

Dear Art,

This letter agreement serves to amend the Executive Retention Agreement dated as
of September 1, 2000, by and between you and PolyMedica Corporation. (the
"Company").

1.       Section 2 Term of Agreement is hereby deleted in its entirety and
replaced with the following in lieu thereof:

         " This Agreement, and all rights and obligations of the parties
         hereunder, shall take effect upon the Effective Date and shall expire
         March 31, 2004. "Term" shall mean the period commencing as of the
         Effective Date and continuing in effect through March 31, 2004."

2.       Section 3.2(a) Termination of Employment is hereby amended by deleting
the first sentence in its entirety and replacing it with the following in lieu
thereof:

         "(a) If the Change in Control Date occurs during the Term, any
         termination of Executive's employment by the Company or by Executive
         during the remainder of the Term (other than due to the death of the
         Executive) shall be communicated by a written notice to the other party
         hereto (the "Notice of Termination"), given in accordance with
         Section 7."

3.       Section 4.2 Compensation is hereby amended by deleting the first
sentence in its entirety and replacing it with the following in lieu thereof:

         "If the Change in Control Date occurs during the Term and Executive's
employment with the Company terminates during the remainder of the Term, the
Executive shall be entitled to the following benefits:"

4.       Section 4.2(a)(i)(3) is hereby added to the Retention Agreement as
         follows:

         "(3) For purposes of any calculations set forth in this Section 4.2,
the annual bonus amount to be used in the calculation shall be Four Hundred
Thousand Dollars ($400,000).

If the foregoing is acceptable to you, please indicate your agreement by signing
a copy of this letter agreement and returning it to the undersigned.

                                              Very truly yours,

<PAGE>

                                           /s/ Samuel L. Shanaman
                                           ----------------------
                                           Samuel L. Shanaman
                                           Lead Director and Interim Chief
                                             Executive Officer

ACCEPTED AND AGREED TO:

/s/ Arthur A. Siciliano, Ph.D.
------------------------------
Arthur A. Siciliano Ph.D.

November 5, 2003
-----------------
Date

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