Document:

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                                                                   Exhibit 10.3

                               SECURITY AGREEMENT

                           Dated as of April 26, 2001

                                     between

                                 GLIATECH INC.,
                                   as Grantor,

                                       and

                  PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P.,
                                  as Purchaser

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                                TABLE OF CONTENTS
                                -----------------

<TABLE>
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ARTICLE I DEFINITIONS..........................................................................................1

   Section 1.1.       Certain Terms............................................................................1
   Section 1.2.       Assignment Agreement Definitions.........................................................2
   Section 1.3.       UCC Definitions..........................................................................2
   Section 1.4.       Other Interpretive Provisions............................................................2

ARTICLE II SECURITY INTEREST...................................................................................3

   Section 2.1.       Grant of Security........................................................................3
   Section 2.2.       Continuing Security Interest; Transfer of Notes..........................................4
   Section 2.3.       Grantors Remains Liable..................................................................5

ARTICLE III REPRESENTATIONS AND WARRANTIES.....................................................................5

   Section 3.1.       Location of Collateral, etc..............................................................5
   Section 3.2.       Ownership; No Liens......................................................................5
   Section 3.3.       Validity.................................................................................6
   Section 3.4.       Authorization, Approval..................................................................6

ARTICLE IV COVENANTS...........................................................................................6

   Section 4.1.       As to Receivables........................................................................6
   Section 4.2.       Transfers and Other Liens................................................................7
   Section 4.3.       Further Assurances.......................................................................8
   Section 4.4.       General Covenants........................................................................8

ARTICLE V RIGHTS AND DUTIES OF THE PURCHASER...................................................................9

   Section 5.1.       Purchaser Appointed Attorney-in-Fact.....................................................9
   Section 5.2.       Purchaser May Perform....................................................................9
   Section 5.3.       Limitations on Duties of Purchaser......................................................10
   Section 5.4.       Reasonable Care.........................................................................10
   Section 5.5.       Indemnification.........................................................................10

ARTICLE VI REMEDIES...........................................................................................10

   Section 6.1.       Certain Remedies........................................................................10

ARTICLE VII MISCELLANEOUS PROVISIONS..........................................................................11

   Section 7.1.       Amendments..............................................................................11
   Section 7.2.       Release of Collateral...................................................................12
   Section 7.3.       Notices.................................................................................12
   Section 7.4.       Waiver; Cumulative Remedies.............................................................12
   Section 7.5.       Successors and Assigns..................................................................12

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<TABLE>
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<S>                                                                                                          <C>
   Section 7.6.       Counterparts............................................................................12
   Section 7.7.       Severability............................................................................12
   Section 7.8.       Governing Law and Jurisdiction..........................................................13
   Section 7.9.       Waiver of Jury Trial....................................................................13

Schedules
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Schedule I                    -         Locations of Certain Collateral
Schedule II                   -         Offices For Filing Financing Statements
Schedule 3.1                            Names and Corporate Reorganizations and Mergers

</TABLE>

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                               SECURITY AGREEMENT

                  THIS SECURITY AGREEMENT (as amended, supplemented or otherwise
modified from time to time, this "SECURITY AGREEMENT"), is dated as of April 26,
2001 and entered into between GLIATECH INC., a Delaware corporation (the
"GRANTOR") and PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P., a Delaware limited
partnership (the "PURCHASER").

                                    RECITALS

                  WHEREAS, the Grantor and the Purchaser have entered into the
Revenue Interests Assignment Agreement, dated as of April 26, 2001 (as amended,
modified or supplemented from time to time, the "ASSIGNMENT AGREEMENT"); and

                  WHEREAS, it is a condition precedent to the payment of the
Purchase Price by the Purchaser under the Assignment Agreement that the Grantor
shall have granted the security interests contemplated by this Security
Agreement.

                  NOW, THEREFORE, for good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the Grantor hereby
agrees, for the benefit of the Purchaser, as follows:

                                   ARTICLE I

                                   DEFINITIONS

         SECTION 1.1. CERTAIN TERMS.

                  The following terms (whether or not underscored) when used in
this Security Agreement, including its preamble and recitals, shall have the
following meanings:

                  "ACCOUNT" shall have the meaning as provided in the UCC.

                  "ASSIGNMENT AGREEMENT" shall have the meaning set forth in the
recitals hereto.

                  "COLLATERAL" shall have the meaning set forth in Section 2.1.

                  "EVENT OF DEFAULT" shall mean a Funding Termination Event.

                  "GENERAL INTANGIBLE" shall have the meaning as provided in the
UCC.

                  "GRANTOR" shall have the meaning set forth in the preamble
hereto.

                  "JOINT CONCENTRATION ACCOUNT" shall have the meaning set forth
in the Assignment Agreement.

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                  "INSTRUMENT" shall have the meaning as provided in the UCC.

                  "LOCKBOX ACCOUNT" shall have the meaning set forth in the
Assignment Agreement.

                  "LOCKBOX AGREEMENT" shall have the meaning set forth in the
Assignment Agreement.

                  "LOCKBOX BANK" shall have the meaning set forth in the
Assignment Agreement.

                  "OBLIGATIONS" shall have the meaning set forth in the
Assignment Agreement.

                  "PLEDGED DEPOSIT ACCOUNTS" shall have the meaning set forth in
Section 2.1(g) hereof.

                  "PROCEEDS" shall have the meaning as provided in the UCC.

                  "PURCHASER CONCENTRATION ACCOUNT" shall have the meaning set
forth in the Assignment Agreement.

                  "RECEIVABLES" mean the Revenue Interests and the Related
Receivables.

                  "RELATED RECEIVABLES" shall have the meaning set forth in
Section 2.1(c).

                  "SECURITY AGREEMENT" shall have the meaning set forth in the
preamble hereto.

                  "SELLER CONCENTRATION ACCOUNT" shall have the meaning set
forth in the Assignment Agreement.

         SECTION 1.2. ASSIGNMENT AGREEMENT DEFINITIONS.

                  Unless otherwise defined herein or the context otherwise
requires, terms used in this Security Agreement, including its preamble and
recitals, have the meanings provided in the Assignment Agreement.

         SECTION 1.3. UCC DEFINITIONS.

                  Unless otherwise defined herein or the context otherwise
requires, terms for which meanings are provided in the UCC as in effect from
time to time in the State of New York are used in this Security Agreement,
including its preamble and recitals, with such meanings.

         SECTION 1.4. OTHER INTERPRETIVE PROVISIONS.

                  (a) The meanings of defined terms are equally applicable to
the singular and plural forms of the defined terms.

                  (b) The words "hereof," "herein," "hereunder" and similar
words refer to this Security Agreement as a whole and not to any particular
provision of this Security Agreement;

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and subsection, Section, Schedule, and Exhibit references are to this Security
Agreement unless otherwise specified.

                  (c) (i) The term "documents" includes any and all instruments,
documents, agreements, certificates, indentures, notices and other writings,
however evidenced.

                      (ii) The term "including" is not limiting and means
"including without limitation".

                      (iii) The term "property" includes any kind of property or
asset, personal or mixed, tangible or intangible, other than real property.

                  (d) Unless otherwise expressly provided herein, (i) references
to agreements (including this Security Agreement) and other contractual
instruments shall be deemed to include all subsequent amendments and other
modifications thereto, but only to the extent such amendments and other
modifications are not prohibited by the terms of any Transaction Document, and
(ii) references to any statute or regulation are to be construed as including
all statutory and regulatory provisions consolidating, amending, replacing,
supplementing, or interpreting the statute or regulation.

                  (e) The captions and headings of this Security Agreement are
for convenience of reference only and shall not affect the interpretation of
this Security Agreement.

                                   ARTICLE II

                                SECURITY INTEREST

         SECTION 2.1. GRANT OF SECURITY.

                  As collateral security for the prompt and complete payment and
performance when due of the Obligations, the Grantor hereby assigns, pledges and
grants to the Purchaser a security interest in all of the Grantor's right,
title, and interest in and to the following property, whether now owned or
hereafter existing or acquired (the "COLLATERAL"):

                  (a) all Revenue Interests;

                  (b) all Assigned Interests;

                  (c) all License Agreements;

                  (d) all Accounts, contract rights, payment intangibles,
Instruments, and General Intangibles, in each case, constituting, comprising,
evidencing or otherwise relating to any of the foregoing in this Section 2.1(any
and all such Accounts, contract rights, payments intangibles, Instruments, and
General Intangibles being the "RELATED RECEIVABLES");

                  (e) all books, records, data bases, and information, in each
case, specifically relating to any of the foregoing in this Section 2.1;

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                  (f) all money now or at any time in the possession or under
the control of, or in transit to, the Lockbox Bank, the Purchaser or the Grantor
relating to any of the foregoing in this Section 2.1; and

                  (g) the Lockbox Account, the Joint Concentration Account and
the Purchaser Concentration Account (collectively, the "PLEDGED DEPOSIT
ACCOUNTS"), all funds on deposit in each such account, all investments arising
out of such funds, all claims thereunder or in connection therewith, and all
cash, securities, rights, and other property at any time and from time to time
received, receivable, or otherwise distributed in respect of such accounts, such
funds, or such investments; and

                  (h) all products and Proceeds of and from any and all of the
foregoing Collateral, all proceeds which constitute property of the types
described in clauses (a) through (g) and, to the extent not otherwise included,
all payments under insurance (whether or not the Purchaser is the loss payee
thereof), including return premiums with respect thereto, or any indemnity,
warranty, or guaranty payable by reason of loss or damage to or otherwise with
respect to any of the foregoing Collateral;

PROVIDED, HOWEVER, that the term "Collateral" shall not include, and the Grantor
shall not be deemed to have granted a security interest in, any of the Grantor's
right, title or interest in, or any rights under, (i) any contract or other
agreement existing on the Closing Date to the extent that such grant would
result in a breach of a term of such contract or agreement prohibiting such
grant without the consent of the other party thereto, other than to the extent
that any such term would be rendered ineffective pursuant to Section 9-318 of
the Uniform Commercial Code of any relevant jurisdiction and (ii) any
Intellectual Property of the Grantor.

         SECTION 2.2. CONTINUING SECURITY INTEREST.

                  This Security Agreement shall create a continuing security
interest in the Collateral and shall:

                  (a) remain in full force and effect until the payment and
performance in full of all the Obligations;

                  (b) be binding upon the Grantor and its successors,
transferees and assigns; and

                  (c) inure, together with the rights and remedies of the
Purchaser, to the benefit of the Purchaser and its successors and assigns.

Upon the payment and performance in full of the Obligations, the security
interest granted herein shall terminate and all rights to the Collateral shall
revert to the Grantor. Upon any such termination, the Purchaser will, at the
Grantor's sole expense, promptly execute and deliver to the Grantor such
instruments and documents necessary and as the Grantor shall reasonably request
to evidence such termination.

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         SECTION 2.3. GRANTOR REMAINS LIABLE.

                  Anything herein to the contrary notwithstanding:

                  (a) the Grantor shall remain liable under the contracts and
agreements included in the Collateral to the extent set forth therein and shall
perform all of its duties and obligations under such contracts and agreements to
the same extent as if this Security Agreement had not been executed;

                  (b) the exercise by the Purchaser of any of its rights and
remedies hereunder shall not release the Grantor from any of its duties or
obligations under any such contracts or agreements included in the Collateral;
and

                  (c) the Purchaser shall have no obligation or liability under
any such contracts or agreements included in the Collateral by reason of this
Security Agreement, and the Purchaser shall not be obligated to perform any of
the obligations or duties of the Grantor thereunder or to take any action to
collect or enforce any claim for payment assigned hereunder.

                                  ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

                  The Grantor represents and warrants to the Purchaser as
follows:

         SECTION 3.1. LOCATION OF COLLATERAL, ETC.

                  (a) On the date hereof, the place(s) of business and chief
executive office of the Grantor and the office(s) where the Grantor keeps its
records concerning the Receivables are located at the addresses set forth on
Item A of SCHEDULE I.

                  (b) The Grantor has no trade name.

                  (c) Except as set forth on SCHEDULE 3.1, during the past five
years, the Grantor has not been known by any name different from the one set
forth on the signature page hereto, and the Grantor has not been the subject of
any merger or other corporate reorganization.

                  (d) None of the Receivables is evidenced by a promissory note
or other instrument.

         SECTION 3.2. OWNERSHIP; NO LIENS.

                  The Grantor owns the Collateral free and clear of any Liens
except for the security interest created by this Security Agreement. No
effective financing statement or other instrument similar in effect covering all
or any part of the Collateral is on file in any recording office, except such as
may have been filed in favor of the Purchaser relating to this Security
Agreement.

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         SECTION 3.3. VALIDITY.

                  This Security Agreement creates a valid security interest in
the Collateral securing the payment and performance in full of the Obligations.
Upon the filing of appropriate financing statements in the applicable filing
offices in the jurisdictions listed in SCHEDULE II, all filings, registrations
and recordings necessary or appropriate to create, preserve, protect and perfect
the first priority security interest granted by the Grantor to the Purchaser in
the Collateral will have been accomplished and will create a perfected security
interest therein prior to the rights of all other Persons therein and subject to
no other Liens, except as set forth in SCHEDULE 3.04 to the Assignment
Agreement.

         SECTION 3.4. AUTHORIZATION, APPROVAL.

                  No authorization, approval, or other action by, and no notice
to or filing with, any Government Authority or other Person is required either:

                  (a) for the grant by the Grantor of the security interest
granted hereby or for the execution, delivery, and performance of this Security
Agreement by the Grantor; or

                  (b) for the perfection of or exercise by the Purchaser of its
rights and remedies hereunder, other than (i) the filing of financing statements
in the offices listed in Item B of SCHEDULE I and (ii) the establishment of the
Pledged Deposit Accounts and the Seller Concentration Account in accordance with
Section 5.10 of the Assignment Agreement.

                                   ARTICLE IV

                                    COVENANTS

                  The Grantor hereby covenants and agrees that, so long as this
Security Agreement shall remain in effect, the Grantor agrees to the following:

         SECTION 4.1. AS TO RECEIVABLES.

                  (a) The Grantor shall keep its place(s) of business and its
chief executive office and the office(s) where it keeps its books and records
(including those concerning the Receivables) and all original copies of the
Distribution Agreements located, in each case, at its address specified in Item
A of SCHEDULE I, or, upon 30 days' prior written notice to the Purchaser, at
such other locations in a jurisdiction where all actions required by the first
sentence of Section 4.4 shall have been taken with respect to the Receivables
and the Distribution Agreements; not change its name or its state or place of
incorporation or organization except upon 30 days' prior written notice to the
Purchaser; and hold and preserve such books and records.

                  (b) Except as otherwise provided in this subsection (b), until
an Event of Default has occurred and is continuing, the Grantor shall, subject
to Section 5.10 of the Assignment Agreement, continue to collect, at its own
expense, all amounts due or to become due the Grantor under the Distribution
Agreements. In connection with such collections, provided no Event of Default
shall have occurred and be continuing, the Grantor may, subject to

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Section 5.10 of the Assignment Agreement, take (and, at the Purchaser's
direction, shall take) such action as the Grantor may deem necessary or
advisable to enforce collection of the applicable Distribution Agreement. At any
time after an Event of Default has occurred and is continuing, the Purchaser
shall have the right to notify the account debtors or obligors under any
Receivables of the security interest of the Purchaser in such Receivables to the
Purchaser and to direct such account debtors or obligors to make payment to the
Purchaser of any amounts due or to become due thereunder and enforce collection
of any of the Receivables by suit or otherwise and surrender, release or
exchange all or any part thereof, or adjust, settle or compromise or extend or
renew for any period (whether or not longer than the original period) any
indebtedness thereunder or evidenced thereby. If an Event of Default has
occurred and is continuing, upon the request of the Purchaser, the Grantor will,
at its own expense, notify any parties obligated on any of the Receivables to
make payment to the Purchaser of any amounts due or to become due thereunder,
and in such event, the Purchaser is authorized to endorse, in the name of the
Grantor, any item representing any payment on or other proceeds of any of the
Receivables.

                  (c) After delivery to the Grantor by the Purchaser of a notice
that an Event of Default has occurred and is continuing: (i) all amounts and
proceeds (including Instruments) received by the Grantor in respect of any
Receivables shall be received in trust for the benefit of the Purchaser
hereunder, shall be segregated from other funds of the Grantor, and shall be
forthwith paid over to the Purchaser in the same form as so received (with any
necessary endorsements) to be held as cash collateral and applied as provided by
this Security Agreement; and (ii) subject to Section 5.10 of the Assignment
Agreement, the Grantor shall not adjust, settle, or compromise the amount or
payment of any Receivable, or release wholly or partly any account debtor or
obligor thereof, or allow any credit or discount thereon.

                  (d) After the occurrence and during the continuance of an
Event of Default, (A) the Purchaser may in its own name or in the name of others
communicate with account debtors in order to verify with them to the Purchaser's
reasonable satisfaction the existence, amount and terms of any Receivables and
(B) the Purchaser shall have the right, at the Grantor's expense, to make test
verifications of the Receivables in any reasonable manner and through any medium
that it considers advisable, and the Grantor agrees to furnish all such
assistance as the Purchaser may reasonably require in connection therewith.

         SECTION 4.2. INSURANCE.

                  The Grantor will maintain or cause to be maintained at all
times insurance against loss or damage sufficient to cover all the Collateral
that are of an insurable nature to the same extent assets of a similar character
are usually so insured by companies similarly situated and owning like assets,
with insurers believed by the Grantor to be responsible and reputable. If an
Event of Default exists at the time any insurance proceeds relating to the
Collateral are received, all such proceeds shall be paid to the Purchaser for
application in accordance with the terms and conditions of the Assignment
Agreement and this Security Agreement.

         SECTION 4.3. TRANSFERS AND OTHER LIENS.

                  The Grantor shall not:

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                  (a) create or suffer to exist any Lien or other charge or
encumbrance upon or with respect to any of the Collateral, except for the
security interest created by this Security Agreement and except as otherwise
permitted by the Assignment Agreement.

                  (b) sell, assign (by operation of law or otherwise) or
otherwise dispose of any of the Collateral, except as otherwise permitted by the
Assignment Agreement; or

         SECTION 4.4. FURTHER ASSURANCES.

                  The Grantor agrees that, from time to time at its own expense,
the Grantor will promptly execute and deliver all further instruments,
assignments, agreements and documents, and take all further action, that may be
reasonably necessary or desirable, or that the Purchaser may reasonably request,
in order to perfect, preserve, and protect any security interest granted or
purported to be granted hereby and the priority thereof or to enable the
Purchaser to exercise and enforce its rights and remedies hereunder with respect
to any Collateral. Without limiting the generality of the foregoing the Grantor
will:

                  (a) if any Collateral shall be evidenced by a promissory note
or other instrument or negotiable document, deliver and pledge to the Purchaser
hereunder such promissory note, instrument or negotiable document duly endorsed
and accompanied by duly executed instruments of transfer or assignment, all in
form and substance reasonably satisfactory to the Purchaser;

                  (b) execute and file such financing or continuation
statements, or amendments thereto, and such other instruments, assignments or
notices, as may be necessary or desirable, or as the Purchaser may request, in
order to perfect and preserve the security interests and other rights granted or
purported to be granted to the Purchaser;

                  (c) furnish to the Purchaser, from time to time, statements
and schedules further identifying and describing the Collateral and such other
reports in connection with the Collateral as the Purchaser may reasonably
request, and all in reasonable detail and in accordance with the terms of the
Assignment Agreement.

With respect to the foregoing and the grant of the security interest hereunder,
the Grantor hereby authorizes the Purchaser to file one or more financing or
continuation statements, and amendments thereto, relative to all or any part of
the Collateral without the signature of the Grantor where permitted by law. A
carbon, photographic, or other reproduction of this Security Agreement or any
financing statement covering the Collateral or any part thereof shall be
sufficient as a financing statement where permitted by law.

         SECTION 4.5. GENERAL COVENANTS.

                  Without limiting any of the foregoing covenants, the Grantor
agrees (a) not to use or permit any Collateral to be used unlawfully or in
material violation of any provision of the Assignment Agreement, this Security
Agreement, any other Transaction Document, or any applicable statute, regulation
or ordinance or any policy of insurance covering the Collateral; and (b) to pay
promptly when due all taxes, assessments, charges, encumbrances and Liens now or
hereafter imposed upon or affecting any Collateral.

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                                   ARTICLE V

                       RIGHTS AND DUTIES OF THE PURCHASER

         SECTION 5.1. PURCHASER APPOINTED ATTORNEY-IN-FACT.

                  The Grantor hereby irrevocably appoints the Purchaser as the
Grantor's attorney-in-fact, with full authority in the place and stead of the
Grantor and in the name of the Grantor or otherwise, from time to time in the
Purchaser's discretion when an Event of Default has occurred and is continuing,
to take any appropriate action and to execute any instrument that the Purchaser
may deem reasonably necessary or advisable to accomplish the purposes of this
Security Agreement (but the Purchaser shall not be obligated to and shall have
no liability to the Grantor or any third party for failure so to do) including,
without limitation:

                  (a) to ask, demand, collect, sue for, recover, compromise,
receive, and give acquittance and receipts for moneys due and to become due
under or in respect of any of the Collateral;

                  (b) to receive, endorse, and collect any drafts or other
instruments, documents, and chattel paper in connection with clause (a) above;

                  (c) to file any claims or take any action or institute any
proceedings that the Purchaser may deem necessary or desirable for the
collection of any of the Collateral or otherwise to enforce the rights of the
Purchaser with respect to any of the Collateral;

                  (d) to perform the affirmative obligations of the Grantor
hereunder (including all obligations of the Grantor pursuant to Section 4.4);

                  (e) to execute and deliver for and on behalf of the Grantor
any and all instruments, documents, agreements, and other writings necessary or
advisable for the exercise on behalf of the Grantor of any rights, benefits or
options created or existing under or pursuant to the Collateral; and

                  (f) to execute endorsements, assignments, or other instruments
of conveyance and transfer.

The Grantor hereby acknowledges, consents and agrees that the power of attorney
granted pursuant to this Section 5.1 is irrevocable and coupled with an
interest.

         SECTION 5.2. PURCHASER MAY PERFORM.

                  If the Grantor fails to perform any agreement contained
herein, the Purchaser may itself perform, or cause performance of, such
agreement, PROVIDED that the Purchaser shall in any event first have given the
Grantor written notice of its intent to do the same and the Grantor shall not
have, within 30 days of such notice (or such shorter period as the Purchaser may
reasonably determine is necessary in order to preserve the benefits of this
Security Agreement with respect to any material portion of the Collateral), paid
such claim or obtained to the Purchaser's satisfaction the release of the claim
or Lien to which such notice relates. The

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Grantor agrees to reimburse the Purchaser upon demand for any costs and
expenses, including, without limitation, reasonable attorneys' fees, the
Purchaser incurs while acting as the Grantor's attorney-in-fact hereunder, all
of which costs and expenses are included in the Obligations secured hereby.

         SECTION 5.3. LIMITATIONS ON DUTIES OF PURCHASER.

                  The Purchaser shall be obligated to perform such duties and
only such duties as are specifically set forth in this Security Agreement, and
no implied covenants or obligations shall be read into this Security Agreement
against the Purchaser. If an Event of Default has occurred and is continuing,
the Purchaser shall exercise the rights and powers vested in it by this Security
Agreement, and shall not be liable (except for its gross negligence or willful
misconduct) with respect to any action taken by it, or omitted to be taken by
it, in accordance with, and subject to the limitations contained in, the
Assignment Agreement.

          SECTION 5.4. REASONABLE CARE.

                  It is understood and agreed between the parties hereto that
the Purchaser's duty with respect to the custody, safekeeping, and physical
preservation of the Collateral in its possession should be to deal with it in
the same manner as the Purchaser deals with similar property for its own
account; PROVIDED, HOWEVER, that the Purchaser shall not be required to make any
presentment, demand, or protest, or give any notice, and need not take any
action to preserve any rights against any other Person with respect to the
Collateral.

                                   ARTICLE VI

                                    REMEDIES

         SECTION 6.1. CERTAIN REMEDIES.

                  If any Event of Default shall have occurred and is continuing:

                  (a) The Purchaser may exercise in respect of the Collateral,
in addition to other rights available to it at law or in equity or otherwise,
all the rights and remedies of a secured party on default under the UCC (whether
or not the UCC applies to the affected Collateral) and also may (i) require the
Grantor to, and the Grantor hereby agrees that it will, at its expense and upon
request of the Purchaser forthwith, assemble all or part of the Collateral as
directed by the Purchaser and make it available to the Purchaser at a place to
be designated by the Purchaser that is reasonably convenient to both parties,
(ii) exercise any and all rights and remedies of the Grantor under or in
connection with the Collateral, (iii) withdraw all monies, securities and other
property in the Pledged Deposit Accounts for application to the Obligations,
(iv) foreclose or otherwise enforce the Purchaser's security interest in any
manner permitted by law or provided for in this Security Agreement, (v) without
notice except as specified below, sell the Collateral or any part thereof in one
or more parcels at public or private sale, at any place or places for cash, on
credit, or for future delivery, and upon such other terms as the Purchaser may
reasonably determine, (vi) recover from the Grantor all costs and expenses,
including, without limitation, reasonable attorneys' fees, incurred or paid by
the Purchaser in exercising any right,

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power, privilege or remedy provided by this Security Agreement or by law, (vii)
enter into property where any Collateral is located and take possession thereof,
and (viii) prior to the disposition of the Collateral, prepare it for
disposition in any manner and to the extent the Purchaser deems appropriate;
PROVIDED, HOWEVER, that notwithstanding the foregoing to the contrary, the
Purchaser may sell or otherwise dispose the Collateral or any portion thereof in
its then condition without any preparation or processing. The Grantor agrees
that, to the extent notice of sale shall be required by law, at least ten (10)
days' prior notice to the Grantor of the time and place of any public sale or
the time after which any private sale is to be made shall constitute reasonable
notification. The Purchaser shall not be obligated to make any sale of
Collateral regardless of notice of sale having been given. The Purchaser may
adjourn any public or private sale from time to time by announcement at the time
and place fixed therefor, and such sale may, without further notice, be made at
the time and place to which it was so adjourned. Upon any sale or other
disposition pursuant to this Security Agreement, the Purchaser shall have the
right to deliver, assign and transfer to the purchaser thereof the Collateral or
portion thereof and transfer to the purchaser thereof the Collateral or portion
thereof so sold or disposed of. Each purchaser at any such sale or other
disposition (including the Purchaser) shall hold the Collateral free from any
claim or right of whatever kind, including any equity or right of redemption of
the Grantor and the Grantor specifically waives (to the extent permitted by law)
all rights of redemption, stay or appraisal which it has or may have under any
rule of law or statute now existing or hereafter adopted.

                  (b) All cash proceeds received by the Purchaser in respect of
any sale of, collection from, or other realization upon all or any part of the
Collateral shall be applied to the Obligations. If any non-cash proceeds are
received in connection with any sale of Collateral, the Purchaser shall not
apply such non-cash proceeds to the Obligations unless and until such proceeds
are converted to cash; PROVIDED, HOWEVER, that if such non-cash proceeds are not
expected on the date of receipt thereof to be converted to cash within one year
after such date, the Purchaser shall nonetheless use commercially reasonable
efforts to convert such non-cash proceeds to cash within such one-year period.
Any surplus of such cash or cash proceeds held by the Purchaser after payment in
full of all the Obligations shall be paid over to the Grantor or to whomsoever
may be lawfully entitled to receive such surplus.

                                  ARTICLE VII

                            MISCELLANEOUS PROVISIONS

         SECTION 7.1. AMENDMENTS.

                  No amendment to or waiver of any provision of this Security
Agreement and no consent to any departure by the Grantor herefrom shall in any
event be effective unless the same shall be in writing and signed by the
Purchaser, and then such waiver or consent shall be effective only in the
specific instance and for the specific purpose for which given.

                                       11
<PAGE>   15

         SECTION 7.2. RELEASE OF COLLATERAL.

                  If any of the Collateral shall be sold, transferred, or
otherwise disposed of by the Grantor in a transaction not expressly prohibited
by the Assignment Agreement, then the Purchaser shall, at the Grantor's written
request, promptly execute and deliver to the Grantor (at the sole cost and
expense of the Grantor) such instruments or documents necessary and as the
Grantor shall reasonably request to release the Liens created hereby on such
Collateral, including any necessary UCC amendment, termination statement or
partial termination statement.

         SECTION 7.3. NOTICES.

                  All notices and other communications shall be given as set
forth in Section 8.03 of the Assignment Agreement.

         SECTION 7.4. WAIVER; CUMULATIVE REMEDIES.

                  (a) No failure to exercise and no delay in exercising, on the
part of the Purchaser, any right, remedy, power, or privilege hereunder, shall
operate as a waiver thereof; nor shall any single or partial exercise of any
right, remedy, power or privilege hereunder preclude any other or further
exercise thereof, or the exercise of any other right, remedy, power or
privilege.

                  (b) The Grantor waives any right to require the Purchaser to
proceed against any Person or to exhaust any Collateral or to pursue any remedy
in such Purchaser's power.

                  (c) The rights, powers and remedies of the Purchaser under
this Security Agreement shall be in addition to all rights, powers and remedies
given to the Purchaser by virtue of any statute or rule of law, the Assignment
Agreement or any other agreement, all of which rights, powers and remedies shall
be cumulative and may be exercised successively or concurrently without
impairing the Purchaser's security interest in the Collateral.

         SECTION 7.5. SUCCESSORS AND ASSIGNS.

                  The provisions of this Security Agreement shall be binding
upon and inure to the benefit of the parties hereto and their respective
successors and assigns, except that the Grantor may not assign or transfer any
of its rights or obligations under this Security Agreement without the prior
written consent of the Purchaser.

         SECTION 7.6. COUNTERPARTS.

                  This Security Agreement may be executed in any number of
separate counterparts, each of which, when so executed, shall be deemed an
original, and all of said counterparts taken together shall be deemed to
constitute but one and the same instrument.

         SECTION 7.7. SEVERABILITY.

                  The illegality or unenforceability of any provision of this
Security Agreement or any instrument or agreement required hereunder shall not
in any way affect or impair the legality

                                       12
<PAGE>   16

or enforceability of the remaining provisions of this Security Agreement or any
instrument or agreement required hereunder.

         SECTION 7.8. GOVERNING LAW AND JURISDICTION.

                  (a) THIS SECURITY AGREEMENT SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK (WITHOUT GIVING
EFFECT TO ITS CONFLICTS OF LAW PRINCIPLES).

                  (b) ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS
SECURITY AGREEMENT MAY BE BROUGHT IN ANY STATE OR FEDERAL COURT OF COMPETENT
JURISDICTION IN THE STATE, COUNTY AND CITY OF NEW YORK. BY EXECUTION AND
DELIVERY OF THIS SECURITY AGREEMENT, THE GRANTOR HEREBY IRREVOCABLY CONSENTS TO
AND ACCEPTS, FOR ITSELF AND IN RESPECT OF ITS PROPERTY, GENERALLY AND
UNCONDITIONALLY THE NON-EXCLUSIVE JURISDICTION OF SUCH COURTS. THE GRANTOR
HEREBY FURTHER IRREVOCABLY WAIVES ANY OBJECTION, INCLUDING ANY OBJECTION TO THE
LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, WHICH IT MAY
NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY ACTION OR PROCEEDING IN SUCH
JURISDICTION IN RESPECT OF THIS SECURITY AGREEMENT OR ANY DOCUMENT RELATED
HERETO.

         SECTION 7.9. WAIVER OF JURY TRIAL.

                  EACH OF THE GRANTOR AND THE PURCHASER HEREBY IRREVOCABLY
WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO
TRIAL BY JURY IN ANY ACTION, PROCEEDING, CLAIM OR COUNTERCLAIM ARISING OUT OF OR
RELATING TO THIS SECURITY AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.
THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR
MODIFICATIONS TO THIS SECURITY AGREEMENT.

                            [Signature page follows]

                                       13
<PAGE>   17

                  IN WITNESS WHEREOF, the Grantor and the Purchaser have caused
this Security Agreement to be duly executed and delivered by their respective
duly authorized officers as of the date first above written.

GRANTOR:                            GLIATECH INC.

                                    By: /s/ STEVEN L. BASTA
                                        -------------------------------
                                         Name: Steven L. Basta
                                         Title: President

PURCHASER:                          PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P.

                                    By:  Paul Capital Management, LLC,
                                         its General Partner

                                         By: /s/ WALTER FLAMENBAUM
                                             ------------------------------
                                             Name:  Walter Flamenbaum, M.D.
                                             Title: Managing Member

                     [SIGNATURE PAGE TO SECURITY AGREEMENT]<PAGE>   1
                                                                Exhibit 10.4

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                     REVENUE INTERESTS ASSIGNMENT AGREEMENT

                           Dated as of April 26, 2001

                                      among

                                 GLIATECH INC.,
                                   as Seller,

                                       and

                  PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P.,
                                  as Purchaser

<PAGE>   2
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                     REVENUE INTERESTS ASSIGNMENT AGREEMENT

                  THIS REVENUE INTERESTS ASSIGNMENT AGREEMENT (as amended,
supplemented or otherwise modified from time to time, this "AGREEMENT") is made
and entered into as of April 26, 2001 by and between GLIATECH INC., a Delaware
corporation (the "SELLER"), and PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P., a
Delaware limited partnership (the "PURCHASER").

                  WHEREAS, the Seller has the right to receive Revenue Interests
(as hereinafter defined); and

                  WHEREAS, the Seller wishes to sell, assign, convey and
transfer to the Purchaser, and the Purchaser wishes to purchase from the Seller,
the Assigned Interests (as hereinafter defined), upon and subject to the terms
and conditions hereinafter set forth; and

                  NOW, THEREFORE, in consideration of the mutual covenants,
agreements representations and warranties set forth herein, the parties hereto
agree as follows:

                                   ARTICLE I

                                   DEFINITIONS

         SECTION 1.01. DEFINITIONS.

         The following terms, as used herein, shall have the following meanings:

         "ADCON TECHNOLOGY" shall mean the proprietary technology set forth and
described on SCHEDULE A hereto.

         "ADCON-L(R) U.S. RELAUNCH" [***].

         "ADCON-L(R) U.S. RELAUNCH TARGET DATE" [***].

         "AFFILIATE" shall mean, with respect to any Person, any other Person
which, directly or indirectly, controls, is controlled by, or is under common
control with, such Person.

         "AGGREGATE PURCHASE PRICE" shall mean the Purchase Price together with
any Subsequent Purchase Prices paid to Seller.

         "AGREEMENT" shall have the meaning set forth in the first paragraph
hereof.

         "APPLICABLE DISCOUNT RATE" [***].

         "APPLICABLE PERCENTAGE" shall mean, as of any date of determination,
the sum of (i) 2.5% [***].

                                       1
<PAGE>   3

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         "ASSIGNED INTERESTS" shall mean the right to receive amounts payable to
the Seller equal to the Applicable Percentage of the Net Sales.

         "ASSIGNMENT DOCUMENTS" shall mean any document or instrument pursuant
to which the Assigned Interests are sold, assigned, conveyed and transferred by
Seller to Purchaser hereunder.

         "AUDIT COSTS" shall mean, with respect to any audit of the books and
records of the Seller with respect to amounts payable or paid under this
Agreement or any License Party Audit, the cost of such audit, including, without
limitation, all fees, costs and expenses incurred in connection therewith.

         "AUDIT REPORTS" shall mean, with respect to a License Party Audit, any
and all reports, findings and other written information related to such License
Party Audit.

         "BANKRUPTCY EVENT" shall mean:

         (i)      the Seller shall commence any case, proceeding or other action
                  (A) under any existing or future law of any jurisdiction,
                  domestic or foreign, relating to bankruptcy, insolvency,
                  reorganization, relief of debtors or the like, seeking to have
                  an order for relief entered with respect to it, or seeking to
                  adjudicate it a bankrupt or insolvent, or seeking
                  reorganization, arrangement, adjustment, winding-up,
                  liquidation, dissolution, composition or other relief with
                  respect to it or its debts, or (B) seeking appointment of a
                  receiver, trustee, custodian or other similar official for it
                  or for all or substantially all of its assets, or the Seller
                  shall make a general assignment for the benefit of its
                  creditors; or

         (ii)     there shall be commenced against the Seller any case,
                  proceeding or other action of a nature referred to in clause
                  (i) above which (A) results in the entry of an order for
                  relief or any such adjudication or appointment, and (B)
                  remains undismissed, undischarged or unbonded for a period of
                  forty-five (45) days; or

         (iii)    there shall be commenced against the Seller any case,
                  proceeding or other action seeking issuance of a warrant of
                  attachment, execution, distraint or similar process against
                  all or substantially all of its assets which results in the
                  entry of an order for any such relief which shall not have
                  been vacated, discharged, stayed, satisfied or bonded pending
                  appeal within forty-five (45) days from the entry thereof; or

         (iv)     the Seller shall take any action in furtherance of, or
                  indicating its consent to, approval of, or acquiescence in,
                  any of the acts set forth in clause (i), (ii) or (iii) above
                  of this definition of "Bankruptcy Event";

         (v)      the Seller shall generally not, or shall be unable to, or
                  shall admit in writing its inability to, pay its debts as they
                  become due; or

                                       2
<PAGE>   4
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         (vi)     Seller shall be Insolvent.

         "BILL OF SALE" shall mean each Bill of Sale pursuant to which the
Seller shall assign to the Purchaser all of its rights and interests in and to
Assigned Interests purchased hereunder, which Bill of Sale shall be
substantially in the form of EXHIBIT C.

         "BUSINESS DAY" shall mean any day other than a Saturday, a Sunday, any
day which is a legal holiday under the laws of the State of New York, or any day
on which banking institutions located in the State of New York are required by
law or other governmental action to close.

         "CHANGE OF CONTROL" shall mean:

         (i)      any Person (other than the Seller, any trustee or other
                  fiduciary holding securities under an employee benefit plan of
                  the Seller or any Affiliate thereof or any controlling
                  stockholder of Seller on the date hereof) becomes the
                  "beneficial owner" (as defined in Rule 13d-3 under the
                  Securities Exchange Act of 1934), directly or indirectly, of
                  securities of Seller representing more than 50% of the
                  combined voting power of Seller's then outstanding securities
                  eligible to vote generally in the election of directors; or

         (ii)     Seller's stockholders approve a merger or consolidation of
                  Seller with any other Person, other than a merger or
                  consolidation which would result in Seller's voting securities
                  outstanding immediately prior thereto continuing to represent
                  (either by remaining outstanding or by being converted into
                  voting securities of the surviving entity) more than 50% of
                  the combined voting power of Seller's voting securities or
                  such surviving entity's voting securities outstanding
                  immediately after such merger or consolidation; PROVIDED,
                  HOWEVER, that a merger or consolidation effected to implement
                  a recapitalization of Seller (or similar transaction) in which
                  no Person acquires more than 50% of the combined voting power
                  of Seller's then outstanding securities shall in no way
                  constitute a Purchase Option Event; or

         (iii)    during any period of two consecutive years (not including any
                  period prior to the date of this Agreement), individuals who
                  at the beginning of such period constitute the Board of
                  Directors of Seller (together with any new director (other
                  than a director designated by a Person who has entered into an
                  agreement with Seller to effect a transaction described in
                  clause (i) or (ii) of this definition of "Change of Control")
                  whose election by such Board of Directors or nomination for
                  election by Seller's stockholders was approved by a vote of a
                  majority of the directors then still in office who either were
                  directors at the beginning of such period or whose election or
                  nomination for election was previously so approved) cease for
                  any reason

                                       3
<PAGE>   5

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                  to constitute at least a majority of the Board of Directors of
                  Seller then in office.

         "CLOSING" shall have the meaning set forth in Section 6.01.

         "CLOSING DATE" shall mean April 26, 2001.

         "CLOSING PURCHASE PRICE PAYMENT" shall have the meaning set forth on
SCHEDULE 2.03.

         "COLLATERAL" shall have the meaning set forth in the Security
Agreement.

         "CONFIDENTIAL INFORMATION" shall mean, as it relates to Seller and the
Products, the Adcon Technology, know-how, trade secrets, confidential business
information, financial data and other like information (including ideas,
research and development, know-how, formulas, schematics, compositions,
technical data, specifications, customer and supplier lists, pricing and cost
information, and business and marketing plans and proposals), inventory, ideas,
algorithms, processes, computer software programs or applications (in both
source code and object code form), client lists and tangible or intangible
proprietary information or material. Notwithstanding the foregoing definition,
Confidential Information shall not include information already in the public
domain at the time such information is disclosed.

         "CREDITS" shall mean any credits, discounts, rebates or other rights of
Distribution Parties to reduce payments owed to Seller in respect of sales of
the Products, which credits, discounts, rebates or other such rights relate
solely to the January 2001 recall by Seller of certain Products.

         "DAILY AMOUNT" shall have the meaning set forth in Section 2.02(a)(i).

         "DEPOSIT ACCOUNTS" shall mean, collectively, the Lockbox Account, the
Joint Concentration Account, the Seller Concentration Account and the Purchaser
Concentration Account, each established and maintained pursuant to the Lockbox
Agreement.

         "DISCREPANCY NOTICE" shall have the meaning set forth in Section
2.02(d).

         "DISTRIBUTION AGREEMENT" shall mean any existing or future agreement
pursuant to which Seller or any affiliate or agent of Seller agrees to market or
sell the Products, whether to end-users, for redistribution by the purchaser
thereof, or otherwise, or to license distribution of the Products or the use of
the Adcon Technology.

         "DISTRIBUTION PARTY" shall mean any person that enters into a
Distribution Agreement with Seller or any affiliate of Seller.

         "DISTRIBUTOR" shall mean any person that acquires Products from the
Seller or any affiliate of the Seller for distribution.

         "DOLLARS" or "US$" shall mean the freely transferable lawful money of
the United States.

                                       4
<PAGE>   6

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         "EMCM" shall mean European Medical Contract Manufacturing, B.V.

         "EUROPEAN RELAUNCH" [***].

         "EXISTING DISTRIBUTION AGREEMENT" shall mean each Distribution
Agreement in existence on the date hereof or as of any date as of which a
representation or warranty herein is deemed made or remade, as applicable.

         "EXCLUDED LIABILITIES AND OBLIGATIONS" shall have the meaning set forth
in Section 2.04.

         "FDA" shall mean the United States Food and Drug Administration.

         "FINANCIAL STATEMENTS" shall mean (i) the consolidated balance sheet of
Gliatech and its subsidiaries at December 31, 1999 and December 31, 2000 and the
related consolidated statements of operations and cash flows and the
consolidated statements of changes in stockholders' equity of the Seller and its
subsidiaries for the years ended December 31, 1999 and December 31, 2000, and
the accompanying footnotes thereto, copies of which are attached hereto as
EXHIBIT B.

         "FUNDING TERMINATION EVENT" shall mean:

                  (i)      the Adcon-L(R) U.S. Relaunch shall not have occurred
                           on or prior to the Adcon-L(R) U.S. Relaunch Target
                           Date;

                  (ii)     a Bankruptcy Event shall have occurred or

                  (iii)    if (A) any representation, warranty or certification
                           made by the Seller in any of the Transaction
                           Documents or in any certificate at any time given by
                           the Seller in writing pursuant hereto or thereto or
                           in connection herewith or therewith shall be
                           inaccurate on the date as of which it was made or
                           deemed made, and such inaccuracy would, individually
                           or in the aggregate with other inaccuracies on the
                           part of Seller, reasonably be expected to have a
                           Material Adverse Effect or (B) there has occurred a
                           breach of or default under any term, covenant, or
                           agreement under any Transaction Document by the
                           Seller, which would, individually or in the aggregate
                           with other breaches on the part of Seller, reasonably
                           be expected to have a Material Adverse Effect, and
                           such false representation, warranty or certification
                           or breach or default, as the case may be, if capable
                           of cure, has not been cured within thirty (30) days
                           following receipt by the Seller from the Purchaser of
                           notice of such false representation, warranty or
                           certification or breach or default, as the case may
                           be and requesting that the same be cured.

         "FUTURE AGREEMENT" shall mean any distribution, licensing or similar
agreement entered into by Seller with any other Person after the date hereof
relating to the marketing and/or sale of any of the Products, as the same may be
amended, supplemented or otherwise modified from

                                       5
<PAGE>   7
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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time to time, including any amendments, supplements or modifications to any
Existing Distribution Agreements that relate to the Products.

         "GAAP" shall mean generally accepted accounting principles in the
United States in effect from time to time.

         "GCPA" shall mean Good Clinical Practice Associates.

         "GOVERNMENT AUTHORITY" means any government, court, regulatory or
administrative agency or commission, or other governmental authority, agency or
instrumentality, whether federal, state or local (domestic or foreign),
including, without limitation, the U.S. Patent and Trademark Office, the FDA and
the U.S. National Institute of Health.

         "GUARANTEED MINIMUM ROYALTIES" shall mean (i) with respect to the
fiscal years 2003 and 2004, $1.6 million, [***].

         "INDEPENDENT CONSULTANT" [***].

         "INITIAL APPLICABLE PERCENTAGE" shall mean the Applicable Percentage in
effect immediately following the Closing.

         "INITIAL ASSIGNED INTEREST" shall mean the right to receive amounts
payable to Seller equal to the Initial Applicable Percentage of the Net Sales.

         "INSOLVENT" shall mean, with respect to Seller, a financial condition
such that the sum of Seller's debts (excluding the obligation of the Seller to
make payments in respect of the Assigned Interests pursuant to this Agreement,
including pursuant to Section 5.07) is greater than the fair market value of
Seller's property.

         "INTELLECTUAL PROPERTY" shall mean, relating solely to the Adcon
Technology and the Products, all inventions (whether patentable or unpatentable
and whether or not reduced to practice), all improvements thereto, and all
patents, patent rights, patent applications and invention disclosures, together
with all reissuance, continuations, continuations-in-part, revisions,
extensions, and reexaminations thereof, all registered or unregistered
trademarks, trade names, service marks, including all goodwill associated
therewith, and copyrights and all applications and registrations for any of the
foregoing, and all Confidential Information.

         "JOINT CONCENTRATION ACCOUNT" shall mean a segregated account
established for the benefit of Seller and Purchaser and maintained at the
Lockbox Bank pursuant to the terms of the Lockbox Agreement and this Agreement.
The Joint Concentration Account shall be the account into which the funds held
in the Lockbox Account are swept by the Lockbox Bank.

         "KNOWLEDGE" shall mean, with respect to Seller, that an officer or
representative of such Person shall have actual knowledge of a particular
matter. Notwithstanding the foregoing, an officer or representative of Seller or
any affiliate of Seller charged with responsibility for the aspect of the
business relevant or related to the matter at issue shall be deemed to have

                                       6
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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knowledge of a particular matter if, in the prudent exercise of his or her
duties and responsibilities, such officer or representative should have known of
such matter.

         "LETTER OF INTENT" shall mean the letter dated March 14, 2001, as
further amended on March 23, 2001, April 20, 2001 and April 23, 2001, between
Paul Capital Partners and the Seller, as the same may be amended to the date
hereof.

         "LICENSE AGREEMENT" shall mean any existing or future distribution,
co-promotion, manufacturing, marketing or partnering agreements entered into by
Seller relating to the Products and/or the Adcon Technology pursuant to which
Seller or any affiliate of Seller grants a license in the Adcon Technology.

         "LICENSEES" shall mean, collectively, the licensees under the License
Agreements; each a "LICENSEE".

         "LICENSE PARTY AUDIT" shall have the meaning set forth in Section
5.12(c).

         "LIENS" shall mean all liens, encumbrances, security interests,
mortgages or charges of any kind.

         "LOCKBOX ACCOUNT" shall mean, collectively any lockbox and segregated
lockbox account established and maintained at the Lockbox Bank pursuant to a
Lockbox Agreement and this Agreement. The Lockbox Account shall be the account
into which all payments made in respect of the sale of the Products are to be
remitted.

         "LOCKBOX AGREEMENT" shall mean any agreement entered into by a Lockbox
Bank, the Seller and the Purchaser, in form and substance reasonably
satisfactory to the parties thereto, pursuant to which, among other things, the
Lockbox Account, the Joint Concentration Account, the Purchaser Concentration
Account and the Seller Concentration Account shall be established and
maintained.

         "LOCKBOX BANK" shall mean any bank or financial institution approved by
the Purchaser and the Seller and is a party to any Lockbox Agreement.

         "LOSSES" shall mean collectively, any and all claims, damages, losses,
judgments, liabilities, costs and expenses (including, without limitation,
reasonable expenses of investigation and reasonable attorneys' fees and expenses
in connection with any action, suit or proceeding).

         "MATERIAL ADVERSE CHANGE" shall mean, with respect to Seller, a
material adverse change in the business, operations, assets or financial
condition of the Seller, taken as a whole, or any other change in the business,
operations, assets or financial condition of Seller, taken as a whole, after the
date hereof a reasonably foreseeable consequence of which would be a Material
Adverse Effect; provided, however, that the items listed on SCHEDULE B shall not
constitute a Material Adverse Change.

                                       7
<PAGE>   9
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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         "MATERIAL ADVERSE EFFECT" shall mean (i) a Material Adverse Change,
(ii) a materially adverse effect on the validity or enforceability of any of the
Transaction Documents, (iii) a material adverse effect on the ability of the
Seller to perform any of its obligations under any of the Transaction Documents,
(iv) a material adverse effect on the rights or remedies of Purchaser under the
Agreement or any of the other Transaction Documents, or (v) a material adverse
effect on the Assigned Interests taken as a whole, including, without
limitation, any material adverse effect on the Products or the ability of the
Seller to market and/or sell the Products.

         "MATERIAL CONTRACTS" shall mean any contract, agreement or other
arrangement to which the Seller is a party or any of the Seller's assets or
properties are bound or committed (other than the Transaction Documents) for
which breach, nonperformance, cancellation or failure to renew could reasonably
be expected to have a Material Adverse Effect.

         "NET SALES" shall mean, for any period of determination, the aggregate
sales revenues of the Products during such period, in finished packaged form as
invoiced by Seller or Licensees to end-users of the Products (or, solely with
respect to sales of the Products to purchasers outside of the U.S. effected by
Distributors, the aggregate sales revenues of the Products in finished packaged
form as invoiced by Seller to such Distributors) less only (i) customary cash,
trade discounts and rebates actually granted or paid, (ii) allowances and
adjustments actually credited to customers for Products that are spoiled,
damaged, outdated, obsolete, returned or otherwise recalled, (iii) charges
included as part of the aggregate sales for freight, postage, shipping and
insurance charges, to the extent invoiced, (iv) taxes, duties or other
governmental charges when included in the invoice, and (v) with respect to
Reformulated Products that contain or otherwise combine Products with one o more
other components, an amount equal to the aggregate sales of such Products during
such period, as invoiced to customers or Distributors, as the case may be,
multiplied by the Revenue Adjustment Factor; PROVIDED, HOWEVER, that solely with
respect to License Agreements, Net Sales shall mean, for any period of
determination, the aggregate sales revenues of Products during the applicable
period in finished packaged form as invoiced by the Licensees less than the
amounts set forth in clauses (i) - (v) hereof.

         "NOTICE OF ELECTION" shall have the meaning set forth in Section
5.05(b).

         "OBLIGATIONS" shall mean any and all obligations of the Seller under
this Agreement and the other Transaction Documents.

         "OFFERED INTERESTS" shall have the meaning set forth in Section
5.05(a).

         "OTHER INTERESTS" shall have the meaning set forth in Section 5.05(a).

         "OWNED INTELLECTUAL PROPERTY" shall have the meaning set forth in
Section 3.12(d).

         "PATENT OFFICE" shall mean the respective patent office (foreign or
domestic) for any Patent.

         "PATENTS" shall mean, relating solely to the Products and/or the Adcon
Technology and not any other products of the Seller or its Affiliates, all
patents, patent applications and patent

                                       8
<PAGE>   10

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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disclosures, together with all reissuance, continuations, continuations-in-part,
revisions, extensions, and reexaminations thereof relating to the Products
and/or the Adcon Technology, composition of matter, formulation, or methods of
manufacture or use thereof, including, without limitation, those identified in
SCHEDULE 3.12(a).

         "PERSON" means an individual, corporation, partnership, association,
trust or other entity or organization, but not including a government or
political subdivision or any agency or instrumentality of such government or
political subdivision.

         "PHARMACEUTICAL PROGRAMS" means the various clinical and preclinical
pharmaceutical programs of the Seller that do not relate to the Products,
including, without limitation, the Cognition Modulation GT-2331 program, the
program relating to development of the Monoclonal Antibodies and the product
development program for schizophrenia and dementia.

         "PMA" shall have the meaning set forth in Section 3.13.

         "PRODUCTS" shall mean any article, composition, apparatus, substance,
chemical, material, method, process or service that includes the Adcon(R)
Technology or Reformulated Products, as disclosed and claimed in the Patents.

         "PROJECTED NET SALES" [***].

         "PROPOSED TRANSFER" shall have the meaning set forth in Section
5.05(a).

         "PURCHASE OPTION EXERCISE PERIOD" shall have the meaning set forth in
Section 5.07(a).

         "PURCHASE OPTION EVENT" shall mean any one of the following events:

                  (i)      any Change of Control;

                  (ii)     [***]

                  (iii)    [***]

                  (iv)     [***]

                                       9
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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                  (v)      [***]

                  (vi)     [***]

                  (vii)    Steve Basta shall not be President of Gliatech or
                           shall have substantially ceased functioning in such
                           capacity at any time prior to April 30, 2003,
                           provided, however, that in the event of Steve Basta's
                           death or permanent disability or if Steve Basta is
                           terminated for cause from his position as President
                           by the Board of Directors of Gliatech, then the fact
                           that Steve Basta shall no longer be acting as
                           President of Gliatech shall not result in a Purchase
                           Option Event if the Seller timely replaces Steve
                           Basta with a Person reasonably acceptable to the
                           Purchaser.

Notwithstanding clause (iii) of this definition of "Purchase Option Event" to
the contrary, in the event of a Transfer of any part of the Other Interests in
accordance with Section 5.05, then such Transfer under such clause (iii) above
shall not constitute a Purchase Option Event.

         "PURCHASE PRICE" shall have the meaning set forth in Section 2.03(a).

         "PURCHASER" shall have the meaning set forth in the first paragraph
hereof.

         "PURCHASER CONCENTRATION ACCOUNT" shall mean a segregated account
established for the benefit of the Purchaser and maintained at the Lockbox Bank
pursuant to the terms of the Lockbox Agreement and this Agreement. The Purchaser
Concentration Account shall be the account into which the funds held in the
Joint Concentration Account which are payable to Purchaser pursuant to this
Agreement are swept by the Lockbox Bank in accordance with the terms of this
Agreement and the Lockbox Agreement.

         "PURCHASER INDEMNIFIED PARTY" shall have the meaning set forth in
Section 8.06(a).

         "PURCHASER OPTION REPURCHASE" shall have the meaning set forth in
Section 5.07(a).

         "PURCHASER'S ACCOUNT" shall mean an account maintained by the Purchaser
at any financial institution and designated in writing by the Purchaser to the
Seller, as the Purchaser may so designate from time to time.

         "PURCHASER'S CONSULTANTS" shall mean, collectively, the Purchaser's
employees, officers, directors, agents or other authorized representatives.

                                       10
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         "QUARTERLY REPORT" shall mean, with respect to the relevant fiscal
quarter of Seller, (i) a report showing all payments made by the Seller to the
Purchaser under this Agreement during such quarter and showing in detail the
basis for the calculation of such payments and (ii) a reconciliation of such
report referred to in clause (i) above to all information and data deliverable
to Seller by the parties to any Distribution Agreements, Future Agreements
and/or License Agreements, together with relevant supporting documentation.

         "REFORMULATED PRODUCT" shall mean a (i) subsequent version of a Product
that represents an improvement, enhancement, refinement or modification of an
existing Product and (ii) a Product that incorporates, contains or combines a
Product with any other component or components that is intended to have the
effect of inhibiting the formation of scarring and adhesions, as disclosed and
claimed in the Patents.

         "REGISTERED INTELLECTUAL PROPERTY" shall have the meaning set forth in
Section 3.12(a).

         "REGULATORY AGENCY" shall mean a regulatory agency with responsibility
for the approval of the marketing and sale of drugs in any country.

         "REMAINING TRANCHE I PAYMENT" shall have the meaning set forth in
Section 2.03(a).

         "REPURCHASE PERIOD" shall have the meaning set forth in Section
5.07(a).

         "REPURCHASE PRICE" shall have the meaning set forth in Section 5.07(a).

         "REVENUE ADJUSTMENT FACTOR" shall mean, with respect to any
Reformulated Product, a fraction the numerator of which is the invoice price of
the related Product, if sold separately, and the denominator of which is the sum
of (x) the invoice price of the related Product, if sold separately, and (y) the
total invoice price of any other components of such Reformulated Product, if
sold separately. If the Product or other components of the Reformulated Product
are not sold separately then the parties hereto will discuss and mutually agree
on the appropriate values of the active and other components of the Reformulated
Product.

         "REVENUE INTEREST PERIOD" shall mean the period from and including
March 30, 2001 through and including December 31, 2012, unless earlier
terminated in accordance with the terms of this Agreement.

         "REVENUE INTERESTS" shall mean, with respect to any Distribution
Agreements other than License Agreements, all of the Seller's rights to receive
payments in respect of sales of the Products, whether to end-users or
Distributors (whether such Sales are made directly or through Licensees) and
with respect to License Agreements, all of Seller's rights under such License
Agreements, including, without limitation, rights to receive payments in respect
of sale of the Products.

         "SECURITY AGREEMENT" shall mean the Security Agreement dated as of the
date hereof by and between the Seller and the Purchaser providing for, among
other things, the grant by the

                                       11
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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Seller in favor of the Purchaser a valid, continuing, perfected lien on and
security interest in, the Assigned Interests and the other Collateral described
therein.

         "SELLER" shall have the meaning set forth in the first paragraph
hereof.

         "SELLER CONCENTRATION ACCOUNT" shall mean a segregated account
established and maintained at the Lockbox Bank pursuant to the terms of the
Lockbox Agreement and this Agreement. The Seller Concentration Account shall be
the account into which the funds remaining in the Joint Concentration Account
after payment therefrom of the amounts payable to Purchaser pursuant to this
Agreement are swept in accordance with the terms of this Agreement.

         "SELLER INDEMNIFIED PARTY" shall have the meaning set forth in Section
8.05(b).

         "SELLER OPTION REPURCHASE" shall have the meaning set forth in Section
5.07(b).

         "SELLER OPTION REPURCHASE PRICE" shall have the meaning set forth in
Section 5.07(b).

         "SELLER'S ACCOUNT" shall have the meaning set forth in Section 2.03(b).

         "SUBSEQUENT PURCHASE PRICE" shall have the meaning set forth in Section
2.03(b).

         "TERM" shall mean the term of this Agreement, which shall commence on
the date hereof and terminate on the earlier of (i) December 31, 2012 and (ii)
the consummation of a Repurchase Event.

         "TRANCHE II PAYMENT" shall have the meaning set forth Section 2.03(a).

         "TRANSACTION DOCUMENTS" shall mean, collectively, this Agreement, the
Warrant, the Bill of Sale, the Security Agreement, and any Lockbox Agreement.
For purposes of the representations and warranties contained in Article III, the
term Transaction Documents shall not include the Lockbox Agreement and any
Assignment Document that is not dated the date hereof and executed by a Seller
and the Purchaser and delivered on the Closing Date.

         "TRANSFER" or "TRANSFERRED" shall mean any sale, conveyance,
assignment, disposition or transfer.

         "TRANSFER NOTICE" shall have the meaning set forth in Section 5.05(a).

         "TRUE-UP AMOUNT" shall have the meaning set forth in Section
2.02(a)(ii).

         "TRUE-UP DATE" for any fiscal quarter shall mean the 20th day following
the end of each such quarter of Seller, unless such date is not a Business Day
in which case the applicable date will be the immediately succeeding Business
Day.

         "UNITED STATES" shall mean the United States of America.

                                       12
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         "UCC" shall mean the Uniform Commercial Code (or any similar or
equivalent legislation) as in effect in any applicable jurisdiction.

         "WARRANT" shall mean the Warrant to be issued by the Seller in favor of
the Purchaser in substantially the form attached hereto as Exhibit G.

         "WEIGHTED AVERAGE APPLICABLE PERCENTAGE" shall mean, with respect to
any fiscal year, the average Applicable Percentage for such fiscal year weighted
on the basis of the amount of Net Sales during such fiscal year against which
such Applicable Percentage was applied in calculating amounts payable pursuant
to Section 2.02(a).

                                   ARTICLE II
                     PURCHASE AND SALE OF ASSIGNED INTERESTS

         SECTION 2.01. PURCHASE AND SALE.

         (a) Upon the terms and subject to the conditions set forth in this
Agreement, Seller agrees to sell, assign, transfer and convey to the Purchaser,
and the Purchaser agrees to purchase from the Seller, at the Closing free and
clear of all Liens (except those Liens created in favor of the Purchaser
pursuant to the Security Agreement and any other Transaction Document), all of
Seller's rights and interests in and to the Initial Assigned Interest.

         (b) Purchaser hereby agrees to purchase, at the option of the Seller
exercisable at the times and in the manner set forth in subsection (c) hereof
and subject to the conditions set forth in Section 6.04(b), an additional
Assigned Interest in the amount designated by the Seller pursuant to subsection
(c) hereof (any such Assigned Interest so acquired, a "SUBSEQUENT ASSIGNED
INTEREST"). Purchaser's ownership interest in the Subsequent Assigned Interest
so acquired shall vest immediately upon Seller's receipt of the payment for such
Subsequent Assigned Interest pursuant to Section 2.03(b) and simultaneously
therewith the Applicable Percentage shall be adjusted to reflect the acquisition
by Purchaser of such Subsequent Assigned Interest.

         (c) Commencing on the date of the Adcon-L(R) U.S. Relaunch (provided
such relaunch shall have occurred on or prior to the Adcon-L(R) U.S. Relaunch
Target Date), Seller shall have the option, subject to satisfaction of the
conditions precedent set forth in Section 6.04(b), to require Purchaser to
purchase additional Assigned Interests equal to (i) [***]. Such option shall
expire on the date that is 12 months following commencement of such option.
Seller may exercise the option granted pursuant to this subsection (c) once, and
upon such exercise, Seller's option, and any further obligation of Purchaser to
acquire Assigned Interests, shall terminate. Seller may at its option require
that the Subsequent Purchase Price payable in respect of any purchase of an
Assigned Interest pursuant to clause (ii) and clause (iii) hereof be paid in
multiple installments of not less than $5 million per installment, which
payments shall be made on such dates as the Seller shall designate at the time
it exercises t option; PROVIDED, HOWEVER,

                                       13
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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that the last such payment must occur on or prior to the date that is 12 months
following exercise of the option.

         SECTION 2.02. PAYMENTS IN RESPECT OF THE ASSIGNED INTEREST.

         (a) Purchaser shall be entitled to receive an amount equal to the
Applicable Percentage of Net Sales made during the Revenue Interest Period,
payable as follows:

                  (i) the Applicable Percentage of (A) proceeds from the sale of
the Products which are received from time to time in the Lockbox Account, and
(B) the amount of any Credits utilized by Distribution Parties in reduction of
amounts paid or payable to Seller, in each case, which shall be swept from the
Joint Concentration Account into the Purchaser Concentration Account on a daily
basis (the "DAILY AMOUNT") pursuant to Section 5.10; and

                  (ii) in the event that the aggregate of the Daily Amounts
received by Purchaser during any fiscal quarter is less than the Weighted
Average Applicable Percentage of Net Sales (and with respect to the fourth
fiscal quarter, after giving effect to any uncollected accounts written off
during the applicable fiscal year up to a maximum of $100,000 through the fiscal
year 2004 and $250,000 thereafter) for such quarter, then on the True-Up Date,
Seller shall pay to the Purchaser an amount equal to such difference (the
"TRUE-UP AMOUNT"). Seller shall, within five (5) Business Days of receipt of any
amounts in respect of any accounts previously written-off, remit to Purchaser
the Applicable Percentage (such Applicable Percentage to be based upon the
Applicable Percentage at the time that such accounts were written-off) of any
such recoveries up to the amount by which prior payments to Purchaser were
reduced pursuant to the preceding sentence.

         (b)      (i)  If, for any fiscal year during the Revenue Interest
Period, the sum of the aggregate Daily Amounts and aggregate True-Up Amounts
paid to Purchaser pursuant to Section 2.02(a) for such fiscal year is less than
the Guaranteed Minimum Royalty for such fiscal year, then Seller shall pay to
Purchaser, within thirty (30) days of the end of such year an amount equal to
such difference.

                  (ii)  [***].

                  (iii) [***].

                  (iv) If, in any year during the Revenue Interest Period, the
sum of the aggregate Daily Amounts and aggregate True-Up Amounts paid to
Purchaser exceeds the Weighted Average Applicable Percentage of Net Sales, and
such Weighted Average Applicable Percentage of Net Sales exceeds the Guaranteed
Minimum Royalty for such year, then within twenty (20) days of Seller's notice,
together with supporting documentation, to Purchaser with respect thereto,
Purchaser shall pay Seller an amount equal to the difference of (A) the sum of
the aggregate Daily Amounts and aggregate True-Up Amounts minus (B) the greater
of (x) the Weighted Average Applicable Percentage of Net Sales for such year,
and (y) the Guaranteed Minimum Royalty for such year.

                                       14
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with the Securities and Exchange Commission.
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         (c) Any payments, other than from funds paid to Purchaser from the
Purchaser Concentration Account pursuant to Section 2.02(a)(i) above, to be made
by Seller to Purchaser hereunder or under any other Transaction Document shall
be made by wire transfer of immediately available funds to Purchaser's Account.

         (d) Within thirty (30) Business Days following delivery to Purchaser of
the Quarterly Report for the fourth fiscal quarter of each fiscal year during
the Revenue Interest Period, to the extent that either Purchaser or Seller has
determined that there is a discrepancy as to the amounts paid to Purchaser
hereunder for such fiscal year, then such Person who has made such determination
may notify the other in writing of such discrepancy indicating in reasonable
detail its reasons for such determination (the "DISCREPANCY NOTICE"). In the
event that Purchaser or Seller delivers to the other party a Discrepancy Notice,
Purchaser and Seller shall meet within ten (10) Business Days (or such other
time as mutually agreed by the parties) after the receiving party has received a
Discrepancy Notice to resolve in good faith such discrepancy. If the discrepancy
has been resolved and, as a result thereof, it is determined that a payment is
owing by Purchaser to Seller or by Seller to Purchaser, then the party owing
such payment shall promptly pay such payment to the other party. If, within
forty-five (45) days after receipt of the Discrepancy Notice, Seller and
Purchaser cannot resolve any such discrepancies, then the Purchaser and Seller
shall promptly instruct their respective firms of independent certified public
accountants to select, within five (5) Business Days thereafter, a third
nationally recognized accounting firm (the "INDEPENDENT ACCOUNTANTS"). After
offering Seller and its representatives and Purchaser and its representatives
the opportunity to present their positions as to the disputed items, which
opportunity shall not extend for more than ten (10) calendar days after the
Independent Accountants have been selected, the Independent Accountants shall
review the disputed matters and the materials submitted by Seller and Purchaser
and, as promptly as practicable, deliver to Seller and Purchaser a statement in
writing setting forth its determination of the proper treatment of the
discrepancies as to which there was disagreement, and that determination will be
final and binding upon the parties hereto without any further right of appeal.
All charges of that accounting firm incurred in making that determination will
be borne one-half by Purchaser and one-half by Seller.

         SECTION 2.03. PURCHASE PRICE.

         (a) In full consideration for the Initial Assigned Interest, and
subject to the terms and conditions set forth herein, the Purchaser shall pay to
the Seller (i) $5.0 million at the Closing (the "CLOSING PURCHASE PRICE
PAYMENT"); (ii) $2.5 million (the "REMAINING TRANCHE I PAYMENT") within three
(3) Business Days following the satisfaction of all of the conditions set forth
in Section 6.04(a); and (iii) if the Adcon-L(R) U.S. Relaunch has occurred on or
prior to the Adcon-L(R) U.S. Relaunch Target Date and at such time the Seller is
in compliance with Section 6.04(b) and provides Purchaser with written
certification that the Adcon-L(R) U.S. Relaunch has occurred, $7.5 million (the
"TRANCHE II PAYMENT") on the later of (i) twenty (20) Business Days after
Purchaser's receipt of Seller's written notice of intent to commence the
Adcon-L(R) U.S. Relaunch and (ii) the date of commencement of the Adcon-L(R)
U.S. Relaunch (the Closing Purchase Price Payment, the Remaining Tranche I
Payment (if and when fu and the Tranche II Payment (if and when funded) are
herein referred to together as the "PURCHASE PRICE").

                                       15
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with the Securities and Exchange Commission.
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The Purchase Price (or any portion thereof) shall be paid by wire transfer of
immediately available funds to the account designated by the Seller (the
"SELLER'S ACCOUNT").

         (b) Purchaser hereby agrees to pay, in full consideration for any
Subsequent Assigned Interest acquired pursuant to Section 2.01(b) and Section
2.01(c) and subject to the terms and conditions set forth herein, (i) [***] (any
such purchase price, the "SUBSEQUENT PURCHASE PRICE"). The Subsequent Purchase
Price shall be paid by wire transfer of immediately available funds to the
Seller's Account within fifteen (15) Business Days after receipt of written
notice of Seller's exercise of such option.

         SECTION 2.04. NO ASSUMED OBLIGATIONS.

         Notwithstanding any provision in this Agreement or any other writing to
the contrary, the Purchaser is acquiring only the Assigned Interests and is not
assuming any liability or obligation of Seller of whatever nature, whether
presently in existence or arising or asserted hereafter, whether under any
Existing Distribution Agreement, Future Agreement, License Agreement or
otherwise. All such liabilities and obligations shall be retained by and remain
obligations and liabilities of the Seller (the "EXCLUDED LIABILITIES AND
OBLIGATIONS").

                                  ARTICLE III

                    REPRESENTATIONS AND WARRANTIES OF SELLER

         The Seller represents and warrants to the Purchaser the following:

         SECTION 3.01. ORGANIZATION.

         Seller is a corporation duly incorporated, validly existing and in good
standing under the laws of its jurisdiction of incorporation, and has all
corporate powers and all licenses, authorizations, consents and approvals
required to carry on its business as now conducted.

         SECTION 3.02. CORPORATE AUTHORIZATION.

         Except as set forth on SCHEDULE 3.02, Seller has all necessary power
and authority to enter into, execute and deliver this Agreement and the other
Transaction Documents to which it is a party and to perform all of the
obligations to be performed by it hereunder and thereunder and to consummate the
transactions contemplated hereunder and thereunder. This Agreement and the other
Transaction Documents have been duly authorized, executed and delivered by
Seller (to the extent a party thereto) and each of this Agreement and each other
Transaction Document to which Seller is a party constitutes the valid and
binding obligation of Seller, enforceable against Seller in accordance with
their respective terms subject, as to enforcement of remedies, to bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting creditors'
rights generally or general equitable principles.

                                       16
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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         SECTION 3.03. GOVERNMENTAL AUTHORIZATION.

         The execution and delivery by Seller of this Agreement and the other
Transaction Documents to which each is a party, and, except as set forth on
SCHEDULE 3.03, the performance by Seller of its obligations hereunder and
thereunder, does not require any notice to, action or consent by, or in respect
of, or filing with, any Government Authority.

         SECTION 3.04. OWNERSHIP.

         Seller immediately prior to the assignment of the Assigned Interests
owns, and is the sole holder of, all the Revenue Interests; and except as set
forth SCHEDULE 3.04, Seller owns, and is the sole holder of, and/or has and
holds a valid, enforceable and subsisting license to, all of those other assets
that are required to produce or receive any payments from any Distribution Party
or payor under and pursuant to, and subject to the terms of, each of the
Existing Distribution Agreements, in each case free and clear of any and all
Liens, except those Liens created in favor of the Purchaser pursuant to the
Security Agreement and any other Transaction Document and other than as set
forth on SCHEDULE 3.04. Seller has not transferred, sold, or otherwise disposed
of, and has not agreed to transfer, sell, or otherwise dispose of any portion of
the Revenue Interests other than as contemplated by this Agreement or the
applicable Existing Distribution Agreement. No Person other than the Seller has
any right to receive the payments payable under any Existing Distribution
Agreement other than (x) in respect of the Assigned Interests, the Purchaser
from and after the Closing Date and (y) as set forth on SCHEDULE 3.04. Seller
has the full right to sell, transfer, convey and assign to the Purchaser all of
Seller's rights and interests in and to the Assigned Interests being sold,
transferred, conveyed and assigned to the Purchaser pursuant to this Agreement
without any requirement to obtain the consent of any Person. By the delivery to
the Purchaser of the executed Assignment Documents, Seller shall transfer,
convey and assign to the Purchaser all of Seller's rights and interests in and
to the Assigned Interests being sold, transferred, conveyed and assigned to the
Purchaser pursuant to this Agreement, free and clear of any Liens, except those
Liens created in favor of the Purchaser pursuant to the Security Agreement and
any other Transaction Document. On the Closing Date, upon payment of the Closing
Purchase Price Payment by the Purchaser to the Seller, and upon the delivery of
the Assignment Documents to the Purchaser by the Seller, the Purchaser shall
have acquired good and valid rights and interests of Seller in and to Assigned
Interests being sold, transferred, conveyed and assigned to the Purchaser
pursuant to this Agreement, free and clear of any and all Liens, except those
Liens created in favor of the Purchaser pursuant to the Security Agreement and
any other Transaction Document and other than as set forth on SCHEDULE 3.04.

         SECTION 3.05. FINANCIAL STATEMENTS.

         The Financial Statements are complete and accurate in all material
respects, were prepared in conformity with GAAP and present fairly in all
material respects the financial position and the financial results of the Seller
and its subsidiaries as of the dates and for the periods covered thereby. There
has been no Material Adverse Change since December 31, 2000.

                                       17
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exhibit, and such confidential portions have been omitted and filed separately
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         SECTION 3.06. NO UNDISCLOSED LIABILITIES.

         Except for those liabilities (i) identified in the Financial
Statements, (ii) set forth on SCHEDULE 3.06 and (iii) incurred by Seller in the
ordinary course of business since December 31, 2000, there are no material
liabilities of the Seller and any of its subsidiaries of any kind whatsoever,
whether accrued, contingent, absolute, determined or determinable, and there is
no condition, situation or set of circumstances which could reasonably be
expected to result in such a material liability.

         SECTION 3.07. SOLVENCY.

         Seller is not insolvent as defined in any federal statute or any
statute of the State of Ohio and the fair market value of the Seller's assets is
greater than the sum of its debts. Assuming consummation of the transactions
contemplated by this Agreement, (i) the present fair saleable value of the
Seller's assets is greater than the amount required to pay its debts as they
become due, (ii) the Seller does not have unreasonably small capital with which
to engage in its business, and (iii) the Seller has not incurred, and does not
have present plans to, does not intend to, incur, debts or liabilities beyond
its ability to pay such debts or liabilities as they become absolute and
matured.

         SECTION 3.08. LITIGATION.

         Except as set forth on SCHEDULE 3.08, there is no (i) action, suit,
arbitration proceeding, claim, investigation or other proceeding pending or, to
the Knowledge of Seller, threatened against the Seller, or (ii) any governmental
inquiry pending or, to the Knowledge of Seller, threatened against the Seller,
in each case with respect to clauses (i) and (ii) above, which, would question
the validity of, or could adversely affect or prevent the consummation of, the
transactions contemplated by this Agreement or could reasonably be expected to
have a Material Adverse Effect. Other than as set forth on SCHEDULE 3.08, there
is no action, suit, claim, proceeding or investigation pending or, to the
Knowledge of Seller, threatened against any other Person relating to the
Products, any of the Existing Distribution Agreements, the Intellectual
Property, the Revenue Interests or the Assigned Interests.

         SECTION 3.09. COMPLIANCE WITH LAWS.

         Except as set forth on SCHEDULE 3.09, Seller (i) is not in violation
of, and to the Knowledge of Seller, under investigation with respect to, and,
(ii) to the Knowledge of Seller, has not been threatened to be charged with or
been given notice of any violation of, with respect to clauses (i) and (ii)
above, any law, rule, ordinance or regulation, judgment, order or decree entered
by any Government Authority applicable to the Seller, the Assigned Interests,
the Revenue Interests or any of the Existing Distribution Agreements which could
reasonably be expected to have a Material Adverse Effect and which, after the
Closing, could reasonably be expected to have a Material Adverse Effect.

                                       18
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         SECTION 3.10. CONFLICTS.

         (a) Neither the execution and delivery of this Agreement or the other
Transaction Documents nor the performance or consummation of the transactions
contemplated hereby or thereby will: (i) contravene, conflict with, result in a
breach or violation of, constitute a default under, or accelerate the
performance provided by, in any material respects any provisions of: (A) any
law, rule or regulation of any Government Authority, or any judgment, order,
writ, decree, permit or license of any Government Authority, to which the Seller
or any of its assets or properties may be subject or bound; or (B) any material
contract, agreement, commitment or instrument to which the Seller is a party or
by which the Seller or any of its assets or properties is bound or committed;
(ii) contravene, conflict with, result in a breach or violation of, constitute a
default under, or accelerate the performance provided by, in any respects any
provisions of the certificate of incorporation or by-laws (or other
organizational or constitutional documents) of the Seller; (iii) except for the
filing of the UCC-1 financing statements required hereunder, require any
notification to, filing with, or consent of, any Person (including, without
limitation, any party to the Existing Distribution Agreements or any licensor of
the Intellectual Property to Seller) or Government Authority; (iv) constitute a
beach of or default under any Existing Distribution Agreement or give rise to
any right of termination, cancellation or acceleration of any right or
obligation of Seller or any other Person or to a loss of any benefit relating to
the Revenue Interests or Assigned Interests, or (v) result in the creation or
imposition of any Lien on (1) the assets or properties of the Seller or (2) the
Assigned Interests, Revenue Interests, any of the Existing Distribution
Agreements or any other Collateral, other than, with respect to clauses (1) and
(2) above, pursuant to the Security Agreement.d A_Toc509902098

         (b) Seller has not granted, and there does not exist, any Lien on the
Revenue Interests, the Assigned Interests, any Existing Distribution Agreement
or any other Collateral other than pursuant to the Security Agreement and other
than as set forth on SCHEDULE 3.10.

         SECTION 3.11. MATERIAL CONTRACTS.

         Seller is not in breach of or in default under any Material Contract to
which it is a party. To the Knowledge of Seller, nothing has occurred and no
condition exists that would permit any other party thereto to terminate any
Material Contract to which Seller is a party, and Seller has not received any
notice or threat of termination of any such Material Contract. To the Knowledge
of Seller, no other party to a Material Contract to which Seller is a party is
in breach of or in default under such Material Contract. All Material Contracts
to which Seller is a party are valid and binding and are in full force and
effect.

         SECTION 3.12. INTELLECTUAL PROPERTY.

         (a) SCHEDULE 3.12(a) sets forth an accurate and complete list of all
(1) Patents and (2) registrations and applications for registration of trade
names, trademarks and copyrights and all material unregistered trademarks and
copyrights, if any ("Registered Intellectual Property"), which are necessary for
the development, manufacture, commercialization, marketing or other use of the
Products by Seller or its licensee(s), except as otherwise disclosed therein
and, which

                                       19
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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are owned by, licensed to, licensed by or otherwise used by Seller. For each
listed Patent and Registered Intellectual Property, Seller has indicated (i) the
owner, (ii) the countries in which such Patent or Registered Intellectual
Property is patented or registered or in which an application for patent or
registration is pending, (iii) the application number, (iv) the registration or
patent number, and (v) the expiration date thereof, as applicable, absent any
patent term extensions. The Patents and Registered Intellectual Property listed
on SCHEDULE 3.12(a) are valid, enforceable and subsisting.

         (b) SCHEDULE 3.12(b) is an accurate and complete list of all
agreements, whether oral or written, express or implied, including, without
limitation, licenses, options, franchise, distribution, marketing and
manufacturing agreements, sponsorships, agreements not to enforce, consents,
settlements, assignments, security interests, liens and other encumbrances or
mortgages, and any amendments(s) renewal(s), novation(s) and termination(s)
pertaining thereto, pursuant to which the Seller exploits Intellectual Property
owned by any third party, and represents all third party-owned Intellectual
Property pertaining to the Products.

         (c) Except as disclosed on SCHEDULE 3.12(c) each agreement specified in
SCHEDULE 3.12(b) is legal, valid, binding, enforceable, and in full force and
effect. The Seller is not in breach of such agreements and, to the Knowledge of
the Seller, no circumstances or grounds exist that would give rise to a claim of
breach or right of rescission, termination, revision, or amendment of any of the
agreements specified in SCHEDULE 3.12(b), including, without limitation, the
signing of this Agreement.

         (d) Other than the Intellectual Property rights licensed by Seller
pursuant to any written agreement listed on SCHEDULE 3.12(b) and the
Intellectual Property rights owned by Seller ("Owned Intellectual Property") no
other Intellectual Property is necessary to make, have made, offer to sell,
sell, have sold, use, import, make public, reproduce, transmit, extract,
distribute, commercialize or market any of the Products, except as disclosed
therein.

         (e) Except as disclosed on SCHEDULE 3.12(e), the Seller possesses sole,
exclusive, valid, and unencumbered title to the Owned Intellectual Property and
is a party to the agreements listed on SCHEDULE 3.12(b), and has not granted any
liens, mortgages, encumbrances on or to any of the Owned Intellectual Property
or agreements listed on SCHEDULE 3.12(b).

         (f) Except as disclosed on SCHEDULE 3.12(f), the Seller has the full
right, power and authority to grant all of the rights and interests granted to
the Purchaser in this Agreement and to the Distribution Party granted under any
Existing Distribution Agreement.

         (g) Except as disclosed on SCHEDULE 3.12(g), there are no unpaid
maintenance or renewal fees currently overdue for any of the Patents or
Registered Intellectual Property, nor have any applications or registrations
therefor lapsed or been abandoned, cancelled or expired.

         (h) Except as disclosed on SCHEDULE 3.12(h), the Seller (to the extent
Seller is an applicant or is otherwise involved in the patent prosecution in
respect of any Patent) and, to the Knowledge of the Seller, each inventor of the
Patents, has complied in all material respects with

                                       20
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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all applicable Patent Office duties of candor and good faith in dealing with any
Patent Office, including the duty to disclose to any Patent Office all
information known to be material to the patentability of each of the Patents.

         (i) Except as disclosed on SCHEDULE 3.12(i), no payments by Seller or
any Distribution Party are, or at any time in the future are expected to become
due to any other Person in respect of the Products or the Intellectual Property.

         (j) Except as disclosed on SCHEDULE 3.12(j), Seller has not undertaken
or omitted to undertake any acts, and, to the Knowledge of Seller, no
circumstance or grounds exist, that would invalidate, reduce or eliminate, in
whole or in part, the enforceability or scope of (i) any of the Intellectual
Property, or, in the case of any Intellectual Property owned or licensed on an
exclusive basis by Seller, Seller's entitlement to exclusively exploit such
Intellectual Property, and (ii) Seller's right to enjoy payments made in respect
of sales of the Products or other revenues from any of the Intellectual
Property.

         (k) Except as disclosed on SCHEDULE 3.12(k), there is, and has been, no
pending, decided or settled opposition, interference, reexamination, injunction,
claim, lawsuit, proceeding, hearing, investigation, complaint, arbitration,
mediation, demand, ITC investigation, decree, or any other dispute,
disagreement, or claim (collectively referred to hereinafter as "Disputes"), nor
to the Knowledge of the Seller has any such Dispute been threatened challenging
the legality, validity, enforceability or ownership of any Intellectual Property
or which would give rise to a credit against the royalties due to Seller from
the applicable Distribution Party for the use of the related Product or licensed
Intellectual Property. To the Knowledge of Seller, no circumstances or grounds
exist that would give rise to such a Dispute. Except as disclosed on SCHEDULE
3.12(k), there are no Disputes by any third party against Seller, Seller has not
received any written notice of any such Dispute, and, to the Knowledge of
Seller, there exists no circumstances or grounds upon which any such claim could
be asserted, as pertaining to Products. Except as disclosed on SCHEDULE 3.12(k),
Seller has not sent any notice of any such Dispute, and to the Knowledge of the
Seller there exists no circumstance or grounds upon which Seller could assert
any such claim, as pertaining to any Product. Except as disclosed on SCHEDULE
3.12(k), no Intellectual Property is subject to any outstanding injunction,
judgment, order, decree, ruling charge, settlement or other disposition of
Dispute, and Seller has fully complied with, paid and otherwise satisfied all
such obligations.

         (l) Except as disclosed on SCHEDULE 3.12(l), there is no pending, or to
the Knowledge of Seller, any threatened, action, suit, or proceeding, or any
investigation or claim by any Governmental Authority to which Seller or, to the
Knowledge of the Seller, any Distribution Party is a party (1) that would be the
subject of a claim for indemnification, if any, by Seller under the related
Distribution Agreement and (2) that the marketing, sale or distribution of any
Product worldwide by Seller, or by any Distribution Party pursuant to the
related Distribution Agreement, does or will infringe on any patent or other
intellectual property rights of any other Person, and there is no basis for any
such action, suit, proceeding, investigation or claim of the type described in
clause (1) or (2) above. To the Knowledge of the Seller, there are no pending
United States, international or foreign patent applications owned by any other
Person, which, if

                                       21
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
--------------------------------------------------------------------------------

issued, would limit or prohibit, in any material respect, the use of the
Products or the licensed Intellectual Property by the applicable Distribution
Party.

         (m) The Seller has taken, and will continue to take, all commercially
reasonable measures and precautions necessary to protect and maintain (1) the
confidentiality of all Intellectual Property (except such Intellectual Property
whose value would be unimpaired by public disclosure) related to the Products
and (2) the value of all Intellectual Property and assets related to the
Products.

         SECTION 3.13. REGULATORY APPROVAL. Seller shall have furnished in a
timely manner to the Purchaser accurate and complete copies of all material
correspondence, telephone and meeting minutes, notices and forms received from
FDA and the Independent Consultant either sent to or received by or on behalf of
Seller relating to (i) the original approval of the Premarket Approval ("PMA")
application and any subsequently filed supplements to that PMA, by the FDA or
any other Regulatory Agency having jurisdiction over the Products, (ii) import
alert, approval or withdrawal of the PMA application and/or supplements to it,
fraud and data integrity policy (AIP), suspension of review of PMA submissions,
and information, inquiries or requests from any U.S. or non-U.S. regulatory
authority having jurisdiction over the current and future marketing and sales of
the Products, and (iii) any correspondence, reports or telephone/meeting minutes
with non-governmental consultants relating to any of the regulatory, marketing
and clinical data issues concerning the Products. Except as set forth on
SCHEDULE 3.13(a), there has been no written, oral or other communication
received by Seller, or to the Knowledge of Seller, by any licensee of the
Products, from the FDA or any other Regulatory Agency in their respective
jurisdictions that would indicate that the FDA or any other Regulatory Agency
(i) is not likely to approve Seller's PMA or similar application with respect to
any of the Products or (ii) is likely to revise or revoke any current approval
granted by the FDA or any other Regulatory Agency with respect to any of the
Products; and nothing has occurred and no condition exists that would cause the
FDA or any other Regulatory Agency to do any of the foregoing. Set forth on
SCHEDULE 3.13(b) is a summary of the status of all applications submitted or
planned to be submitted to the FDA relating to the Products.

         SECTION 3.14. TRANSFER OF IP RIGHTS.

         The Seller is not transferring to the Purchaser any interest in any
Patents, other patents or other Intellectual Property of Seller.

         SECTION 3.15. SUBORDINATION.

         Other than as set forth on SCHEDULE 3.15, the claims and rights of the
Purchaser created by this Agreement and any other Transaction Document in and to
the Assigned Interests, the Revenue Interests and any other Collateral are not
subordinated to any creditor of any Seller or any other Person.

                                       22
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
--------------------------------------------------------------------------------

         SECTION 3.16. PLACE OF BUSINESS.

         Seller's principal place of business and chief executive office are set
forth on SCHEDULE 3.16.

         SECTION 3.17. BROKER'S FEES.

         Seller has not taken any action which would entitle any Person to any
commission or broker's fee in connection with the transactions contemplated by
this Agreement.

         SECTION 3.18. OTHER INFORMATION.

         Except as set forth on SCHEDULE 3.18, no written statement,
information, report or materials prepared by or on behalf of Seller and
furnished to the Purchaser by or on behalf of the Seller in connection with this
Agreement or any transaction contemplated hereby or thereby, no written
representation, warranty or statement made by the Seller in any Transaction
Document, and no schedule or exhibit hereto, in each case with respect to any of
the foregoing contains any untrue statement of a material fact.

         SECTION 3.19. DISTRIBUTION AGREEMENTS.

         Except as set forth on SCHEDULE 3.19(a), the Existing Distribution
Agreements are in full force and effect and except for such correspondence and
written communication as may be identified on SCHEDULE 3.19(b), there has been
no correspondence or other written communication sent by or on behalf of Seller
to, or received by or on behalf of Seller from, any Distribution Party, the
subject matter of which would reasonably be expected to have a Material Adverse
Effect.

         (a)      With respect to the Existing Distribution Agreements:

                  (i)      Except for that which, individually or in the
                           aggregate, would not reasonably be expected to have a
                           Material Adverse Effect, each such Existing
                           Distribution Agreement is in full force and effect
                           and has not been impaired, waived, altered or
                           modified in any respect, whether by way of any
                           sublicense, consent or otherwise and no licensee has
                           granted a sublicense under any Existing Distribution
                           Agreement.

                  (ii)     Except for that which, individually or in the
                           aggregate, would not reasonably be expected to have a
                           Material Adverse Effect, the Distribution Party under
                           each such Existing Distribution Agreement has not
                           been released, in whole or in part, from any of its
                           obligations under such Existing Distribution
                           Agreement.

                  (iii)    Seller has not received (A) any notice of any
                           Distribution Party's intention to terminate such
                           Existing Distribution Agreement in whole or in part
                           or (B) any notice requesting any amendment,
                           alteration or modification of

                                       23
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
--------------------------------------------------------------------------------

                           such Existing Distribution Agreement or any
                           sublicense or assignment thereunder.

                  (iv)     To the Knowledge of Seller, nothing has occurred and
                           no condition exists that would adversely impact the
                           right of Seller to receive any payments payable under
                           the Existing Distribution Agreement. Neither Seller
                           nor, to the Knowledge of Seller, any Distribution
                           Party has taken any action or omitted to take any
                           action, that would adversely impact the right of the
                           Purchaser to receive the Assigned Interests or the
                           Applicable Percentage of the Net Sales.

                  (v)      Other than as set forth on SCHEDULE 3.19(b)(v), all
                           payments required to be made under the terms of each
                           Existing Distribution Agreement have been made. To
                           the Knowledge of Seller, no payment required to be
                           made under the terms of any Existing Distribution
                           Agreement has been subject to any claim pursuant to
                           any right of rescission, set-off, counterclaim or
                           defense. The operation of any of the terms of any
                           Existing Distribution Agreement, or the exercise of
                           any rights thereunder, will not render such Existing
                           Distribution Agreement unenforceable, in whole or in
                           part.

                  (vi)     Except for that which, individually or in the
                           aggregate, would not reasonably be expected to have a
                           Material Adverse Effect, such Existing Distribution
                           Agreement has not been satisfied in full, discharged,
                           canceled, terminated, subordinated or rescinded, in
                           whole or in part. Such Distribution Agreement is the
                           entire agreement between the Seller party thereto and
                           the Distribution Party thereto relating to the
                           subject matter thereof and constitutes the only
                           document, agreement or instrument that relates to the
                           sales of the related Products.

                  (vii)    Except for that which, individually or in the
                           aggregate, would not reasonably be expected to have a
                           Material Adverse Effect, such Existing Distribution
                           Agreement is the legal, valid and binding obligation
                           of the Seller and the Distribution Party thereto,
                           enforceable against Seller and such Distribution
                           Party in accordance with its terms, subject, as to
                           enforcement of remedies, to bankruptcy, insolvency,
                           reorganization, moratorium or similar laws affecting
                           creditors' rights generally and general equitable
                           principles. The execution, delivery and performance
                           of such Existing Distribution Agreement was and is
                           within the corporate powers of the Seller and, to the
                           Knowledge of Seller, the Distribution Party thereto.
                           Such Existing Distribution Agreement was duly
                           authorized by all necessary action on the part of,
                           and validly executed and delivered by, the Seller
                           and, to the Knowledge of Seller, the Distribution
                           Party thereto. There is no breach or default, or
                           event which upon notice or the passage of time, or
                           both, could give rise to any breach or default, in
                           the

                                       24
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
--------------------------------------------------------------------------------

                           performance of such Existing Distribution Agreement
                           by the Seller or, to the Knowledge of Seller, the
                           Distribution Party thereto.

                  (viii)   Except for that which, individually or in the
                           aggregate, would not reasonably be expected to have a
                           Material Adverse Effect, the representations and
                           warranties made in each Existing Distribution
                           Agreement by the Seller were as of the date made true
                           and correct in all material respects.

         SECTION 3.20. INSURANCE

         There is in full force and effect insurance policies maintained by
Seller with an insurance company rated not less than [***], with coverages and
in amounts customary for companies of comparable size and condition similarly
situated in the same industry as the Seller, including without limitation
product liability insurance, directors and officers insurance and insurance
against litigation liability, subject only to such exclusions and deductible
items as are usual and customary in insurance policies of such type. A copy of
Seller's insurance policy or insurance policies covering litigation liabilities
is attached hereto as SCHEDULE 3.20.

                                   ARTICLE IV

                 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

         The Purchaser represents and warrants to the Seller the following:

         SECTION 4.01. ORGANIZATION.

         The Purchaser is a limited partnership duly formed, validly existing
and in good standing under the laws of the State of Delaware, and has all
partnership powers and all licenses, authorizations, consents and approvals
required to carry on its business as now conducted.

         SECTION 4.02. AUTHORIZATION.

         The Purchaser has all necessary power and authority to enter into,
execute and deliver this Agreement and to perform all of the obligations to be
performed by it hereunder. This Agreement has been duly authorized, executed and
delivered by the Purchaser and constitutes its valid and binding obligation of
the Purchaser, enforceable against the Purchaser in accordance with its terms,
subject, as to enforcement of remedies, to bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting creditors' rights generally
and general equitable principles.

         SECTION 4.03. BROKER'S FEES.

         The Purchaser has not taken any action which would entitle any Person
to any commission or broker's fee in connection with the transactions
contemplated by this Agreement.

                                       25
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         SECTION 4.04. CONFLICTS.

         Neither the execution and delivery of this Agreement or the other
Transaction Documents nor the performance or consummation of the transactions
contemplated hereby or thereby will: (i) contravene, conflict with, result in a
breach or violation of, constitute a default under, or accelerate the
performance provided by, in any material respects any provisions of: (A) any
law, rule or regulation of any Government Authority, or any judgment, order,
writ, decree, permit or license of any Government Authority, to which the
Purchaser or any of its assets or properties may be subject or bound; or (B) any
material contract, agreement, commitment or instrument to which the Purchaser is
a party or by which the Purchaser or any of its assets or properties is bound or
committed; (ii) contravene, conflict with, result in a breach or violation of,
constitute a default under, or accelerate the performance provided by, in any
respects any provisions of organizational or constitutional documents of the
Purchaser; or (iii) require any notification to, filing with, or consent of, any
Person or Government Authority.

         SECTION 4.05. CONSENTS.

         The execution and delivery by the Purchaser of this Agreement and the
other Transaction Documents to which it is a party, and the performance by the
Purchaser of its obligations hereunder and thereunder, does not require any
notice to, action or consent by, or in respect of, or filing with, any
Governmental Authority or Person.

         SECTION 4.06. FINANCIAL CAPACITY.

         The Purchaser has sufficient funds available to pay to the Seller the
Closing Purchase Price Payment and the Purchaser shall have sufficient funds
available to pay to the Seller the Remaining Tranche I Payment, the Tranche II
Payment and any Subsequent Purchase Prices when and if such payments become due
and payable in accordance with the terms of this Agreement.

         SECTION 4.07. EXPERIENCE; ACCREDITED INVESTOR STATUS.

         The Purchaser is an "accredited investor" within the meaning of Rule
501 of Regulation D under the Securities Act of 1933 and was not organized for
the specific purpose of acquiring the Assigned Interests or the Warrant.
Purchaser has sufficient knowledge and experience in investing in companies
similar to Seller in terms of Seller's stage of development so as to be able to
evaluate the risks and merits of Purchaser's investment in Seller and Purchaser
is able financially to bear the risks thereof. Purchaser has had an opportunity
to discuss Seller's business, management and financial affairs with Seller's
management. The Assigned Interests and the Warrant are being acquired for
Purchaser's own account for the purpose of investment and not with a view to or
for sale in connection with any distribution thereof. Purchaser understands that
the Assigned Interests and the Warrant have not been registered under the
Securities Act of 1933 by reason of their issuance in a transaction exempt from
the registration requirements of the Securities Act of 1933 pursuant to Section
4(2) thereof or Rule 505 or 506 promulgated under the Securities Act of 1933.

                                       26
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                                    ARTICLE V

                                    COVENANTS

         During the Term, each party hereto (as the case may be) agrees that:

         SECTION 5.01. CONSENTS AND WAIVERS.

         Seller shall use commercially reasonable efforts to obtain any required
consents, acknowledgements, certificates or waivers so that the transactions
contemplated by this Agreement may be consummated and shall not result in any
default or breach or termination of any of the Distribution Agreements.

         SECTION 5.02. ACCESS; BOOKS AND RECORDS.

         (a) Promptly after receipt by Seller of notice of any action, claim,
investigation, proceeding (commenced or threatened), certificate, offer,
proposal, correspondence or other written communication relating to the
transactions contemplated by this Agreement, the Revenue Interests or any of the
Distribution Agreements or License Agreements, Seller shall inform the Purchaser
of the receipt of such notice and the substance of such action, claim,
investigation, proceeding, certificate, offer, proposal, correspondence or other
written communication and, if in writing shall furnish the Purchaser with a copy
of such notice and any related materials with respect to such action, claim,
investigation, proceeding, certificate, offer, proposal, correspondence or other
written communication.

         (b) Seller shall keep and maintain, or cause to be kept and maintained,
at all times accurate and complete books and records. Seller shall keep and
maintain, or cause to be kept and maintained, at all times full and accurate
books of account and records adequate to correctly reflect all payments paid
and/or payable with respect to Assigned Interests and all deposits made into the
applicable Deposit Accounts.

         (c) The Purchaser and any of the Purchaser's Consultants shall have the
right, from time to time, to visit Seller's offices and properties where Seller
keeps and maintains its books and records relating or pertaining to the Revenue
Interests, the Assigned Interests and the other Collateral for purposes of
conducting an audit of such books and records, and to inspect, copy and audit
such books and records, during normal business hours, and, upon five (5)
Business Days written notice given by the Purchaser to Seller, Seller will
provide the Purchaser and any of the Purchaser's Consultants reasonable access
to such books and records, and shall permit the Purchaser and any Purchaser's
Consultants to discuss the business, operations, properties and financial and
other condition of Seller or any of its Affiliates relating or pertaining to the
Revenue Interests, the Assigned Interests and the other Collateral with officers
of such parties, and with their independent certified public accountants (to the
extent such independent certified accountants agree to discuss such matters with
the Purchaser). Purchaser's visits to Seller's offices pursuant to this
subsection (c) shall occur not more than once per fiscal quarter; PROVIDED,
HOWEVER, that Purchaser may so visit more frequently to the extent that there
has occurred an

                                       27
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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event a reasonably foreseeable consequence of which is a
Material Adverse Effect and Purchaser's visit or visits to Seller's offices in
connection therewith are for purposes related to such event.

         (d) In the event any audit of the books and records of Seller relating
to the Revenue Interests, Assigned Interests, and the other Collateral by the
Purchaser and/or any of the Purchaser's Consultants reveals that the amounts
paid to the Purchaser hereunder for the period of such audit have been
understated by more than the greater of $20,000 or 5% of the amounts determined
to be due for the period subject to such audit, then the Audit Costs in respect
of such audit shall be borne by the Seller; and in all other cases, such Audit
Costs shall be borne by the Purchaser.

         SECTION 5.03. MATERIAL CONTRACTS.

         Seller shall comply with, in its commercially reasonably judgment, all
material terms and conditions of and fulfill all of its obligations under all
the Material Contracts to which it is a party.

         SECTION 5.04. CONFIDENTIALITY; PUBLIC ANNOUNCEMENT.

         (a) All information furnished by the Purchaser to Seller or by
Seller to the Purchaser, including the Confidential Information, in connection
with this Agreement and the transactions contemplated hereby, as well as the
terms, conditions and provisions of this Agreement, shall be kept confidential
by the Seller and the Purchaser, and shall be used by the Seller and the
Purchaser only in connection with this Agreement and the transactions
contemplated hereby, except to the extent that such information (i) is already
known by the party to whom the information is disclosed or is already in the
public domain at the time the information is disclosed, (ii) thereafter becomes
lawfully obtainable from other sources, (iii) is required to be disclosed in any
document to be filed with any Government Authority, or (iv) is required to be
disclosed under securities laws, rules and regulations applicable to the Seller
or the Purchaser, as the case may be, or pursuant to the rules and regulations
of the Nasdaq National Market or any other stock exchange or stock market on
which securities of either the Seller or the Purchaser may be listed for
trading. Notwithstanding the foregoing, the Seller and the Purchaser may
disclose such information to their partners, directors, employees, managers,
officers, investors, bankers, advisors, trustees and representatives on a
need-to-know basis, PROVIDED that such Persons shall be informed of the
confidential nature of such information and shall be obligated to keep such
information confidential pursuant to the terms of this Section 5.04(a).

         (b) Except as required by law or the rules and regulations of
any securities exchange or trading system or the FDA or any Government Authority
with similar regulatory authority, or except with the prior written consent of
the other party (which consent shall not be unreasonably withheld), neither
party shall issue any press release or make any public statement with respect to
the transactions contemplated by this Agreement.

                                       28
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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         SECTION 5.05. RIGHT OF FIRST REFUSAL.

         (a) If Seller at any time during the Term proposes to Transfer (each, a
"PROPOSED TRANSFER") any of the Revenue Interests (other than the Assigned
Interests); (the "OTHER INTERESTS"), then the Seller shall, at least thirty (30)
days prior to the closing of such Proposed Transfer, give written notice (the
"TRANSFER Notice") to the Purchaser setting forth (i) the Other Interests that
are to be Transferred pursuant to such Proposed Transfer (the "OFFERED
INTERESTS"), (ii) the anticipated date of the closing of such Proposed Transfer,
(iii) the names and addresses of the proposed transferees, and (iii) the
material terms of such Proposed Transfer, including the cash and/or other
consideration to be received in respect of such Proposed Transfer.
Notwithstanding anything contained herein to the contrary, the Seller shall be
permitted, from time to time, to enter into agreements and transactions relating
to the Adcon Technology, including, without limitation, License Agreements and
Distribution Agreements, none of which shall constitute a Proposed Transfer.

         (b) Upon the receipt of any Transfer Notice, the Purchaser will
have the option, but not the obligation, to purchase all, but not less than all,
of all the Offered Interests, on the same terms as are specified in the Transfer
Notice, PROVIDED, that the Purchaser will have the right to substitute cash in
the amount of the fair market value of any non-cash consideration proposed to be
received from the proposed transferee(s). Within twenty (20) days after the
Purchaser's receipt of the Transfer Notice, the Purchaser will give a written
notice (a "NOTICE OF ELECTION") to the Seller stating whether it elects to
exercise such option.

         (c) Failure by the Purchaser to give a Notice of Election within
such time period specified in subsection (b) of this Section 5.05 will be deemed
an election by the Purchaser not to exercise its option to purchase all the
Offered Interests. The closing of the purchase and sale of the Offered Interests
to the Purchaser will take place as soon as is reasonably practicable on such
date and at such time and place, in each case as the Purchaser may reasonably
determine but not later than twenty (20) days following the Seller's receipt of
the Notice of Election. If the Purchaser does not elect to purchase all of the
Offered Interests hereunder, the Seller will thereafter be free for a period of
ninety (90) days after expiration of the twenty (20) day period referred to
subsection (b) of this Section 5.05 to consummate the Proposed Transfer
described in the Transfer Notice to the transferee(s) specified therein, at the
price and on substantially identical terms set forth therein. However, if such
Proposed Transfer is not consummated within such 90-day period, the Seller will
not Transfer any of the Offered Interests as have not been purchased within such
period without again complying with all of the provisions of this Section 5.05.

         (d) In connection with the consummation of a Proposed Transfer
of the Offered Interests by the Seller to any other Person pursuant to subparts
(a) through (c) above (a "PERMITTED TRANSFER"), the Purchaser agrees that it
will (i) promptly execute and deliver to the Seller such UCC termination
statements and other documents as may be necessary to give effect to such
Permitted Transfer and (ii) take such other action or provide such other
assistance as may be necessary to allow the Permitted Transfer to be
consummated. In addition, Purchaser agrees that, for purposes of the
representations, warranties and covenants hereunder, such Offered

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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Interests transferred pursuant to any such Permitted Transfer shall not be
deemed to be "Revenue Interests" under this Agreement.

         SECTION 5.06. QUARTERLY REPORTS.

         Seller shall, promptly after the end of each fiscal quarter of the
Seller (or, if applicable fiscal quarter) (but in no event later than ninety
(90) days following the end of such quarter), produce and deliver to the
Purchaser a Quarterly Report for such quarter, together with a certificate of a
senior officer of Seller certifying that to the knowledge of such officer (i)
such Quarterly Report is a true and complete copy and (ii) any statements and
any data and information therein prepared by Seller are true, correct and
accurate in all material respects.

         SECTION 5.07. PURCHASE OPTIONS.

         (a) In the event that a Purchase Option Event shall occur, the
Purchaser shall have the right, but not the obligation (the "PURCHASER OPTION
REPURCHASE"), exercisable within one hundred eighty (180) days with respect to a
Purchase Option Event other than a Funding Termination Event and three hundred
sixty (360) days with respect to a Funding Termination Event of the type
described in clause (ii) or (iii) of the definition thereof, of its receipt of
notice from the Seller of the Purchase Option Event (the "PURCHASE OPTION
EXERCISE PERIOD"), to require the Seller to repurchase from the Purchaser the
Assigned Interests for a repurchase price equal to (i) if the Purchase Option
Event occurs on or prior to the date that is twelve (12) months following the
Closing Date, the sum of (A) [***]; and (ii) if the Purchase Option Event occurs
after the date that is twelve (12) months following the Closing Date, an amount
such that the amount of such repurchase price, together with all amounts paid to
Purchaser in respect of the Assigned Interests, discounted annually at the
Applicable Discount Rate to the date or dates on which the Aggregate Purchase
Price or installments thereof were paid to Seller, equals the Aggregate Purchase
Price (the "REPURCHASE PRICE"). In the event that the Purchaser elects to
exercise its right as provided in the immediately preceding sentence, then the
Seller shall, within forty-five (45) days following the Seller's receipt of the
Purchaser's repurchase election notice (the "REPURCHASE PERIOD"), repurchase
from the Purchaser the Assigned Interests at the Repurchase Price, the payment
of which shall be made by wire transfer, in immediately available funds, to the
Purchaser's Account designated by the Purchaser in such election notice.

         (b) Seller shall have the option (the "SELLER OPTION
REPURCHASE") on each March 31 and September 30 following the date that is two
(2) years after the Closing Date to repurchase the Assigned Interests for a
repurchase price (the "SELLER OPTION REPURCHASE PRICE") equal to an amount such
that the amount of such repurchase price, together with all amounts paid to
Purchaser in respect of the Assigned Interests, [***], equals the Aggregate
Purchase Price. Payment of the Seller Option Repurchase Price shall be made by
wire transfer of immediately available funds to the Purchaser's Account
designated by the Purchaser in such election notice.

         (c) In connection with the consummation of a Purchaser Option
Repurchase or Seller Option Repurchase pursuant to subparts (a) and (b) above (a
"REPURCHASE EVENT"), the Purchaser agrees that it will (i) promptly execute and
deliver to the Seller such UCC termination statements

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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and other documents as may be necessary to release Purchaser's Lien on the
collateral and otherwise give effect to such Repurchase Event and (ii) take such
other action or provide such other assistance as may be necessary to give effect
to the Repurchase Event.

         SECTION 5.08. SECURITY AGREEMENT.

         Seller shall at all times until the Obligations of the Seller are paid
and performed in full grant in favor of the Purchaser a valid, continuing, first
perfected lien on and security interest in the Revenue Interests, the Assigned
Interests and the other Collateral described therein.

         SECTION 5.09. COMMERCIALLY REASONABLE EFFORTS; FURTHER ASSURANCE.

         (a) Subject to the terms and conditions of this Agreement, each party
hereto will use its commercially reasonable efforts to take, or cause to be
taken, all actions and to do, or cause to be done, all things necessary under
applicable laws and regulations to consummate the transactions contemplated by
this Agreement. The Purchaser and Seller agree to execute and deliver such other
documents, certificates, agreements and other writings (including any financing
statement filings requested by the Purchaser) and to take such other actions as
may be reasonably necessary in order to consummate or implement expeditiously
the transactions contemplated by this Agreement and to vest in the Purchaser
good, valid and marketable rights and interests in and to the Assigned Interests
free and clear of all Liens, except those Liens created in favor of the
Purchaser pursuant to the Security Agreement and any other Transaction Document.

         (b) Each of the parties hereto shall execute and deliver such
additional documents, certificates and instruments, and to perform such
additional acts, as may be reasonably requested and necessary or appropriate to
carry out and effectuate all of the provisions of this Agreement and to
consummate all of the transactions contemplated by this Agreement.

         (c) Seller and the Purchaser hereto shall cooperate and provide
assistance as reasonably requested by the other party in connection with any
litigation, arbitration or other proceeding (whether threatened, existing,
initiated, or contemplated prior to, on or after the date hereof) to which any
party hereto or any of its officers, directors, shareholders, agents or
employees is or may become a party or is or may become otherwise directly or
indirectly affected or as to which any such Persons have a direct or indirect
interests, in each case relating to this Agreement, the Assigned Interests or
any other Collateral, or the transactions described herein or therein.

         SECTION 5.10. REMITTANCE TO LOCKBOX ACCOUNT.

         (a) Within thirty (30) days after the date of this Agreement, the
parties hereto shall enter into a Lockbox Agreement in form and substance
reasonably satisfactory to the parties hereto and the Lockbox Bank, which
Lockbox Agreement will provide for, among other things, the establishment and
maintenance of a Lockbox Account, a Joint Concentration Account, a Seller
Concentration Account and a Purchaser Concentration Account in accordance with
the

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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terms herein and therein. Any Purchaser Concentration Account shall be held
solely for the benefit of Purchaser, but shall be subject to the terms and
conditions of this Agreement, the Security Agreement and the other Transaction
Documents. Funds deposited into the Lockbox Account shall be swept by the
Lockbox Bank on a daily basis into the Joint Concentration Account and
immediately subsequent thereto, at the direction of the Seller, the Daily Amount
shall be swept into the Purchaser Concentration Account. Purchaser shall have
immediate and full access to any funds held in Purchaser Concentration Account
not subject to any conditions or restrictions whatsoever. After the Daily Amount
is swept into the Purchaser Concentration Account the amounts remaining in the
Joint Concentration Account shall then be swept, at the direction of the Seller,
into the Seller Concentration Account. Seller shall have immediate and full
access to any funds held in Seller Concentration Account not subject to any
conditions or restrictions whatsoever.

         (b) Seller shall pay for all fees, expenses and charges of the Lockbox
Bank by debiting the Seller Concentration Account.

         (c) Seller shall cause all payments in respect of sales of the Products
and in respect of royalties received from Licensees to be remitted directly by
the applicable party into the Lockbox Account. Without in any way limiting the
foregoing, commencing on the Closing Date and thereafter, any and all payments
in respect of sales of the Products received by Seller shall be deposited into
the Lockbox Account within five (5) Business Days of Seller's receipt thereof.

         (d) With respect to any Future Agreement entered into by Seller from
and after the date hereof Seller shall (i) at the time of the execution and
delivery of such Future Agreement, instruct any party thereto under such Future
Agreement to remit to the Lockbox Account when due all applicable payments in
respect of sales of the Products and in respect of royalties received from
Licensees that are due and payable to Seller in respect of or derived from such
Future Agreement during the Term and (ii) deliver to Purchaser evidence of such
instruction and of such applicable party's agreement thereto.

         (e) Seller shall not have any right to terminate the Lockbox Bank
without Purchaser's prior written consent. Any such consent, if Purchaser
desires to give, shall be subject to the satisfaction of each of the following
conditions to the satisfaction of Purchaser:

              (i)    the successor Lockbox Bank shall be reasonably acceptable
                     to Purchaser;

              (ii)   Purchaser, Seller and the successor Lockbox Bank shall have
                     entered into a lockbox agreement substantially in the form
                     of the Lockbox Agreement initially entered into;

              (iii)  all funds and items in the accounts subject to the Lockbox
                     Agreement to be terminated shall be transferred to the new
                     accounts held at the successor Lockbox Bank prior to the
                     termination of the then existing Lockbox Bank; and

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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              (iv)   Purchaser shall have received evidence that the applicable
                     parties making payments in respect of sales of the Products
                     have been instructed to remit all future payments in
                     respect of sales of the Products to the new accounts held
                     at the successor Lockbox Bank.

         SECTION 5.11. SELLER'S ADDITIONAL COVENANTS.

         (a) In the event that Seller becomes aware that any Intellectual
Property licensed by it to a Licensee under any of the Distribution Agreements
or any License Agreements infringes or violates any third party Intellectual
Property, Seller shall promptly use commercially reasonable efforts to attempt
to secure the right to use such Intellectual Property on behalf of itself and
the affected Licensee and shall pay all costs and amounts associated with
obtaining any such license, without any charge to the Licensee or any reduction
in the Assigned Interests.

         (b) Seller shall duly perform and observe all of Seller's
covenants and obligations under each Distribution Agreement and License
Agreement in all material respects. Upon the occurrence of a material breach of
any of the Distribution Agreements or License Agreements by any other party
thereto, which is not cured as provided therein, Seller thereto shall in its
commercially reasonable judgment, seek to enforce all of its rights and remedies
thereunder.

         (c) Seller shall not, without the prior written consent of the
Purchaser, which consent shall not be unreasonably withheld:

              (i)    Forgive, release or compromise any amount owed to Seller
                     and relating to the Assigned Interest, except that Seller
                     shall not be obligated to obtain the consent of Purchaser
                     with respect to any action on the part of the Seller that
                     impacts the Assigned Interest of Purchaser in an amount not
                     to exceed $25,000;

              (ii)   Waive, amend, cancel or terminate, exercise or fail to
                     exercise, any of its material rights constituting or
                     relating to the Revenue Interests in a manner which could
                     reasonably by expected to materially adversely affect the
                     Assigned Interests;

              (iii)  Amend, modify, restate, cancel, supplement, terminate or
                     waive any provision of any Distribution Agreement or
                     License Agreement, or grant any consent thereunder, or
                     agree to do any of the foregoing, including, without
                     limitation, entering into any agreement with the
                     Distribution Party or License Party, as the case may be,
                     under the provisions of such Distribution Agreement or
                     License Agreement in each case which could reasonably be
                     expected to have a Material Adverse Effect; or

              (iv)   Create, incur, assume or suffer to exist any Lien, or
                     exercise any right of rescission, offset, counterclaim or
                     defense, upon or with respect to the Assigned Interests or
                     the other Collateral, or agreeing to do or suffering to

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                     exist any of the foregoing, except for any Lien or
                     agreements in favor of the Purchaser granted under or
                     pursuant to this Agreement and the other Transaction
                     Documents and except for the Liens set forth on SCHEDULE
                     3.04.

         (d) The Seller shall provide the Purchaser with written notice as
promptly as practicable (and in any event within five (5) Business Days) after
becoming aware of any of the following:

              (i)    the occurrence of a Bankruptcy Event;

              (ii)   any breach of any provision of this Agreement or any other
                     Transaction Document;

              (iii)  any representation or warranty made or deemed made by the
                     Seller in any of the Transaction Documents to which it is a
                     party or in any certificate delivered to the Purchaser
                     pursuant hereto shall prove to be untrue, inaccurate or
                     incomplete in any material respect on the date as of which
                     made or deemed made;

              (iv)   any breach or default by Seller of a covenant or agreement
                     hereunder or under any other Transaction Document that is
                     not cured within the applicable cure period;

              (v)    the occurrence of a Purchase Option Event (other than a
                     Funding Termination Event); or

              (vi)   any sublicense by a Licensee of any rights licensed
                     pursuant to any Distribution Agreement.

         (e) Promptly (but in no event later than five (5) Business Days) after
(i) receiving written or, to the Knowledge of Seller, oral notice from a
Distribution Party or License Party, as the case may be, (A) terminating or
expressing any intention to terminate the related Distribution Agreement or
License Agreement or (B) alleging any breach of or default under such
Distribution Agreement or License Agreement by the Seller or (C) asserting the
existence of any facts, circumstances or events which alone or together with
other facts, circumstances or events could reasonably be expected (with or
without the giving of notice or passage of time or both) to give rise to a
breach of or default under or right to terminate such Distribution Agreement or
License Agreement or (ii) otherwise Seller having Knowledge of any fact,
circumstance or event which alone or together with other facts, circumstances or
events could reasonably be expected (with or without the giving of notice or
passage of time or both) to give rise to a material breach of or default under
such Distribution Agreement or License Agreement by Seller or a right to
terminate such Distribution Agreement or License Agreement by such Distribution
Party or License Party, as the case may be, in each case, Seller shall give a
written notice to the Purchaser describing in reasonable detail the relevant
breach, default or termination event, including a copy

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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of any written notice received from such Distribution Party or License Party, as
the case may be, and, in the case of any breach or default or alleged breach or
default by Seller, describing any corrective action Seller proposes to take.

         (f) Seller shall, at Seller's sole expense, either directly or by
causing the Licensee to do so, take any and all actions and prepare, execute,
deliver and file any and all agreements, documents or instruments which are
necessary or desirable to (A) diligently maintain the applicable licensed
Intellectual Property and the Patents and (B) diligently defend such licensed
Intellectual Property and such Patents against infringement or interference by
any other Persons, and against any claims of invalidity or unenforceability, in
any jurisdiction (including, without limitation, by bringing any legal action
for infringement or defending any counterclaim of invalidity or action of a
third party for declaratory judgment of non-infringement or non-interference).
Seller shall not, and shall use commercially reasonable efforts to cause the
applicable Licensee not to, disclaim or abandon, or fail to take any action
necessary or desirable to prevent the disclaimer or abandonment of, the
applicable Patents or other Intellectual Property.

         (g) Seller shall use commercially reasonable efforts to secure and
maintain, or, where a Distribution Party or License Party, as the case may be,
is required to do so under any Distribution Agreement or License Agreement,
assist such Distribution Party or License Party, as the case may be, in securing
and maintaining, all regulatory and other governmental approvals, clearances,
registrations and permits which may be required to manufacture, market and/or
sell any and all of the Products.

         (h) Seller shall, to the extent required by the applicable licensee,
timely produce and deliver to the applicable Distribution Party invoices for
payments owing Seller under the respective Distribution Agreement.

         (i) The Seller shall, in good faith, devote sufficient resources to the
development of the Products in order to meet the Projected Net Sales, [***].
Notwithstanding the foregoing, if regulatory or commercial concerns cause the
Seller's management, in the exercise of their good faith judgment, to decide to
substantially terminate the development of the Products or to reduce the funds
the Seller dedicates to the development of the Products, then the Seller shall
not be required to devote a level of resources to the development of the
Products in order to meet the Projected Net Sales. During the development stage
for the Products, representatives of each of the Seller and the Purchaser shall
discuss, no less frequently than quarterly, the status of the Products and the
anticipated expenditures on the Products for the upcoming fiscal quarter.

         (j) After the Closing, the Seller shall:

             (i)     identify a prospective Director or Vice President of
                     Regulatory Affairs within three (3) months of the Closing
                     and [***], which Vice President or Director shall report
                     directly to the President of the Seller (or, in the case of
                     a Director, shall report directly to the President until
                     such time as a Vice President of Regulatory Affairs is
                     hired); and

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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              (ii)   use commercially reasonable efforts to [***] identified on
                     SCHEDULE 5.11(j) within [***] and will fill all of the
                     positions listed on SCHEDULE 5.11(j) [***]; provided,
                     however, that the Seller may, at its reasonable discretion,
                     combine or reassign responsibilities for specific positions
                     listed on SCHEDULE 5.11(j) in order to meet the operational
                     and organizational objectives of Seller.

       (k)    [***].

       (l)    Within six (6) months of the Closing Date, the Seller shall:

              (i)    [***];

              (ii)   [***]; and

              (iii)  [***].

         (m) Seller shall use commercially reasonable efforts to continue to
diligently pursue and develop a second source for [***].

         (n) During the Revenue Interest Period, the Seller shall maintain
insurance policies with insurance companies rated not less than [***] with
coverages and in amounts Seller believes to be customary for companies of
comparable size and condition similarly situated in the same industry as the
Seller, including without limitation, product liability insurance and directors
and officers insurance.

         (o) The Seller will not Transfer all or any part of its interests in
the Products (other than pursuant to any Distribution Agreements, License
Agreements and Future Agreements) to a third party purchaser or licensee, as
applicable, unless such third party purchaser or licensee, as applicable,
assumes in writing all of the obligations of the Seller hereunder, including the
obligation to make all payments in respect of the Assigned Interests to the
Purchaser; provided, however, for the avoidance of doubt, in no event shall a
party to a Distribution Agreement, License Agreement or Future Agreement be
required to assume the obligations of the Seller hereunder.

         (p) The Seller shall, on behalf of Purchaser, engage [***] as an
outside, independent auditor that will conduct a regulatory review of Seller, at
Seller's expense, semiannually for the two (2) year period immediately following
the Closing Date. [***] will act at the direction of Purchaser.

         (r) The Seller shall, on a timely basis, provide the Purchaser with
copies of semiannual audits of the EMCM facility conducted by [***].

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         SECTION 5.12. FUTURE AGREEMENTS.

         (a) If Seller, at any time and from time to time during the term of
this Agreement, proposes to materially change the form of Distribution Agreement
it utilizes, or proposes in connection with any transaction or transactions with
a Distribution Party to materially vary the terms of the related Distribution
Agreement from those contained in the prevailing form of Distribution Agreement,
then Seller shall promptly provide to Purchaser such revised form of
Distribution Agreement or, at least three (3) Business Days prior to the
execution and delivery of any Distribution Agreement that includes a material
deviation from the terms of the prevailing form of Distribution Agreement, give
written notice to the Purchaser indicating that Seller proposes to enter into
such Future Agreement and the anticipated date of execution of such proposed
Future Agreement.

         (b) [***].

         (c) To the extent Seller has the right to perform or cause to be
performed inspections or audits under any of the License Agreements regarding
payments payable and/or paid to Seller thereunder (each, a "License Party
Audit"), Seller shall, at the reasonable request of the Purchaser, cause such
License Party Audit to be promptly performed (it being understood that it shall
not be a reasonable request if, in the good faith belief of Seller, the
requested License Party Audit would impair Seller's commercial relationship with
the applicable License Party). In conducting a License Party Audit, Seller may
engage its then retained internationally recognized independent public
accounting firm, or, if the Seller elects otherwise, such other internationally
recognized independent public accounting firm reasonably acceptable to the
Purchaser. Promptly after completion of any License Party Audit (whether or not
requested by the Purchaser), the Seller shall promptly deliver to the Purchaser
an Audit Report in respect of such License Party Audit. With respect to any
License Agreement under which Seller has a right to perform or cause to be
performed a License Party Audit, in the event the Purchaser requests Seller to
perform a License Party Audit and such License Party Audit is in fact performed
by or on behalf of the Seller, then if the results thereof reveal that the
amounts paid to the Purchaser hereunder in respect of such License Agreement for
the period of such License Party Audit have been understated by more than the
greater of $20,000 or five percent (5%) of the amounts determined to be due for
the applicable period of such License Party Audit, then the Audit Costs incurred
by the Seller in respect of such License Party Audit shall be borne by the
Seller. In all other cases the Audit Costs incurred by the Seller in respect of
a License Party Audit shall be borne by the Purchaser.

         SECTION 5.13. SELLER'S POST-CLOSING DELIVERIES.

         Notwithstanding anything contained in Sections 6.01 and 6.02 to the
contrary, the Seller shall take the following actions within the time periods
set forth below in this Section 5.13:

         (a) Within seven (7) Business Days following the Closing Date, the
Seller shall deliver to the Purchaser the following:

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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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              (i)    all the legal opinions identified in Sections 6.02(e)(i)
                     and (e)(ii);

              (ii)   all the items identified in Section 6.02(i)(A) for the
                     Seller as such items shall be certified by the appropriate
                     Government Authority to the extent that such Government
                     Authority customarily certifies such items;

              (iii)  the items identified in Section 6.02(i)(B) for Seller; and

              (iv)   the items identified in Section 6.02(i)(D) for the Seller.

         (b) Within seven (7) Business Days following the Closing Date, the
Seller shall take all necessary actions to perfect the security interest granted
by the Seller in favor of the Purchaser in the Collateral under the Security
Agreement, including, without limitation, executing appropriate Form UCC-1
Financing Statements and filing such financing statements in the offices listed
in 6.02(g), and, if the Purchaser shall reasonably request that Seller prepare
and file financing statements in any other jurisdictions, the Seller shall
promptly cause such financing statements to be prepared and filed in any other
offices necessary to perfect the security interests granted under the Security
Agreement, and the Seller shall have delivered evidence of same to the Purchaser
(including delivering a copy of any such Form UCC-1 Financing Statements).

         SECTION 5.14. LICENSING AGREEMENT.

         Notwithstanding anything contained herein to the contrary, Seller shall
be permitted to enter into License Agreements; provided, however, that any such
agreement shall not constitute a sale of all or substantially all of the assets
relating to the Adcon Technology.

         SECTION 5.15. RETENTION OF PRESIDENT.

         The Seller will use commercially reasonable efforts to retain Steve
Basta as President of Gliatech until April 30, 2003; provided, however, that in
the event of Steve Basta's death or permanent disability or if Steve Basta is
terminated for cause from his position as President by the Board of Directors of
Gliatech, then the Seller will replace Steve Basta with a Person reasonably
acceptable to the Purchaser.

         SECTION 5.16. ADDITIONAL PURCHASER COVENANT.

         The Purchaser agrees that it will not short-sell the Seller's common
stock, $0.01 par value per share, acquired by the Purchaser upon exercise of the
Warrant, until the Warrant has been exercised in full by the Purchaser.

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                                   ARTICLE VI

                 THE CLOSING; CONDITIONS TO CLOSING AND FUNDING

         SECTION 6.01. THE CLOSING.

         Subject to the closing conditions set forth in Sections 6.02 and 6.03,
the closing of the purchase and sale of the Initial Assigned Interests (the
"CLOSING") shall take place at the offices of Morrison & Foerster LLP, 1251
Avenue of the Americas, 9th Floor, New York, New York 10104 USA, on the Closing
Date. If all conditions are determined to be satisfied (or any of such
conditions are duly waived) at the Closing (whether or not delayed), the Closing
shall be consummated.

         SECTION 6.02. CONDITIONS APPLICABLE TO THE PURCHASER.

         Subject to Section 5.13, the obligations of the Purchaser to effect the
Closing and the payment of the Closing Purchase Price Payment shall be subject
to the satisfaction of each of the following conditions, any of which may be
waived by the Purchaser in its sole discretion:

         (a) ACCURACY OF REPRESENTATIONS AND WARRANTIES. The representations and
warranties of the Seller set forth in this Agreement and the other Transaction
Documents shall be true, correct and complete in all material respects both on
the date of this Agreement and as of the Closing Date (with the same force and
effect as if such representations and warranties were made anew at and as of the
Closing Date, except to the extent that any such representations or warranties
which by its terms is made as of a specified date, in which case such
representations or warranties shall have been true, correct and complete in all
respects as of such specified date).

         (b) NO ADVERSE CIRCUMSTANCES. Except as set forth in SCHEDULE B, there
shall not have occurred or be continuing any event or circumstance (including
any development with respect to the efficacy of the Products or the licensed
Intellectual Property or the use or expected future use of the same as opposed
to competing products) which could reasonably be expected to have a Material
Adverse Effect.

         (c) LITIGATION. No action, suit, litigation, proceeding or
investigation shall have been instituted, be pending or threatened (i)
challenging or seeking to make illegal, to delay or otherwise directly or
indirectly to restrain or prohibit the consummation of the transactions
contemplated by this Agreement, or seeking to obtain damages in connection with
the transactions contemplated by this Agreement, or (ii) seeking to restrain or
prohibit the Purchaser's acquisition or future receipt of the Assigned
Interests. There shall not have been in effect any injunction, order, judgment
or decree restricting, preventing or enjoining the consummation of the
transactions contemplated by this Agreement.

         (d) OFFICER'S CERTIFICATE. The Purchaser shall have received at the
Closing a certificate of the executive officer of the Seller pursuant to which
such officer certifies that the

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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conditions set forth in Sections 6.02(a), (b) and (c) have been satisfied in all
respects as of the Closing Date.

         (e) LEGAL OPINIONS.

             (i)     The Purchaser shall have received an opinion of Jones, Day,
                     Reavis & Pogue dated the Closing Date, in form and
                     substance satisfactory to the Purchaser and its counsel, to
                     the effect set forth in EXHIBIT F. In rendering such
                     opinion, the Seller's counsel shall be entitled to take
                     such qualifications and exceptions as are customary for
                     counsel in New York to take when rendering opinions of this
                     nature.

             (ii)    The Purchaser shall have received an opinion of patent
                     counsel to the Seller, dated the Closing Date, in form and
                     substance reasonably satisfactory to the Purchaser's
                     counsel.

         (f) BILL OF SALE. A Bill of Sale shall have been executed and delivered
by Seller to the Purchaser and Purchaser shall have received the same.

         (g) SECURITY AGREEMENT. The Security Agreement shall have been duly
executed and delivered by all the parties thereto and shall be in form of
EXHIBIT D hereto, together with proper financing statements (including Form
UCC-1s) fully executed for filing under the UCC and/or any other applicable law,
rule, statute or regulation relating to the perfection of a security interest in
filing offices in the jurisdictions listed on SCHEDULE 6.02(g).

         (h) STATEMENT WITH RESPECT TO REGULATORY MATTERS. The Purchaser
shall have received the statement of [***] of Hyman, Phelps & McNamara PC,
regulatory counsel to the Seller, to the effect that based on his discussions
with the Seller and his review of documents, he is not aware of any material
fact or circumstance related to FDA regulatory matters the subject of which has
not been adequately disclosed on the disclosure schedules attached to this
Agreement. [***] will also provide to the Purchaser a statement with respect to
the clinical trial sites that have been audited as of the date of this
Agreement.

         (i) CORPORATE DOCUMENTS. The Purchaser shall have received on
the Closing Date, a certificate, dated the Closing Date, of a senior officer of
Seller (the statements made in which shall be true and correct on and as of the
Closing Date), certifying that: (A) attaching copies, certified by such officer
as true and complete, of Seller's certificate of incorporation and by-laws or
other organizational documents (together with any and all amendments thereto)
certified by the appropriate Government Authority as being true, correct and
complete copies; (B) attaching copies, certified by such officer as true and
complete, of resolutions of the board of directors of Seller authorizing and
approving the execution, delivery and performance by Seller of this Agreement,
the other Transaction Documents and the transactions contemplated herein and
therein; (C) setting forth the incumbency of the officer or officers of Seller
who have executed and delivered this Agreement and the other Transaction
Documents including therein a signature specimen of each such officer or
officers; (D) attaching copies, certified by such officer as true

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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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and complete, of certificates of the appropriate Government Authority of the
jurisdiction of formation, stating that Seller is in good standing under the
laws of such jurisdiction or, if any such certificate is not available from a
Government Authority, a statement by such officer containing an equivalent
confirmation; and (E) there has not occurred a Funding Termination Event (but
with respect to only clause (ii) in the definition thereof) or a Purchase Option
Event.

         SECTION 6.03. CONDITIONS APPLICABLE TO THE SELLER.

         The obligation of the Seller to effect the Closing shall be subject to
the satisfaction of each of the following conditions, any of which may be waived
by the Seller in its sole discretion:

         (a) ACCURACY OF REPRESENTATIONS AND WARRANTIES. The representations and
warranties of the Purchaser set forth in this Agreement shall have been true,
correct and complete in all respects both on the date of this Agreement and as
of the Closing Date (with the same force and effect as if such representations
and warranties were made anew at and as of the Closing Date, except to the
extent that any such representations or warranties which by its terms is made as
of a specified date, in which case such representations or warranties shall have
been true, correct and complete in all respects on and as of such specified
date).

         (b) LITIGATION. No action, suit, litigation, proceeding or
investigation shall have been formally instituted, be pending or threatened (i)
challenging or seeking to make illegal, to delay or otherwise directly or
indirectly to restrain or prohibit the consummation of the transactions
contemplated by this Agreement, or seeking to obtain damages in connection with
the transactions contemplated by this Agreement, or (ii) seeking to restrain or
prohibit the Purchaser's acquisition or future receipt of the Assigned
Interests.

         (c) OFFICER'S CERTIFICATE. The Seller shall have received at the
Closing a certificate of an officer or member of the general partner of the
Purchaser certifying that the conditions set forth in Sections 6.03(a) and (b)
have been satisfied, in all respects as of the Closing Date.

         (d) FULL PAYMENT. The Closing Purchase Price Payment due at Closing
shall have been tendered by the Purchaser to the Seller by wire transfer of
immediately available funds to the Seller's Account identified to the Purchaser
on or prior to the Closing.

         (e) SECURITY AGREEMENT. The Security Agreement shall have been duly
executed and delivered by all the parties thereto shall and be in the form of
EXHIBIT D hereto.

         SECTION 6.04. CONDITIONS TO PAYMENTS OF THE REMAINING TRANCHE I
PAYMENT, THE TRANCHE II PAYMENT AND THE SUBSEQUENT PURCHASE PRICES.

         (a) The obligation of the Purchaser to pay the Remaining Tranche I
Payment pursuant to Section 2.03(a) is subject to the conditions precedent (any
of which conditions may be waived by the Purchaser in its sole discretion),
which conditions are set forth on EXHIBIT H hereto.

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         (b) The obligations of the Purchaser to pay the Tranche II Payment or
to acquire Subsequent Assigned Interests pursuant to Section 2.01(b) are subject
to the following conditions precedent (any of which conditions may be waived by
the Purchaser in its sole discretion):

              (i)    The Adcon-L(R)U.S. Relaunch shall have occurred;

              (ii)   no Funding Termination Event shall have occurred and be
                     continuing;

              (iii)  neither a Purchase Option Exercise Period or, if
                     applicable, the Repurchase Period, shall have commenced;

              (iv)   there shall not have occurred and be continuing a Material
                     Adverse Change;

              (v)    subject to Section 8.04, the representations and warranties
                     set forth in Article III shall be true and correct in all
                     material respects on the date of the consummation of the
                     Tranche II Payment or any Subsequent Purchase Date, as
                     applicable (with the same force and effect as if such
                     representations and warranties were made anew at and as of
                     the date of the consummation of the Tranche II Payment or
                     any Subsequent Purchase Date, as applicable, except to the
                     extent that any such representations or warranties which by
                     its terms is made as of a specified date, in which case
                     such representations or warranties shall have been true,
                     correct and complete in all respects as of such specified
                     date);

              (vi)   this Agreement has not been terminated pursuant to the
                     second sentence of Section 7.01;

              (vii)  the Seller shall have complied in all material respects
                     with the covenants set forth herein;

              (viii) the Seller shall have satisfied the conditions set forth on
                     Exhibit I hereto; and

              (ix)   the Purchaser shall have received a certificate of an
                     executive officer of the Seller pursuant to which such
                     officer certifies that the conditions set forth in
                     subsections (i) through (vii) of this Section 6.04 have
                     been satisfied.

         SECTION 6.05. FUNDING TERMINATION EVENT.

         Upon the occurrence and during the continuation of a Funding
Termination Event, any and all obligations of the Purchaser to make any
installment payments of the purchase price hereunder shall cease and terminate.
If any Funding Termination Event shall have occurred and be continuing, the
Purchaser may exercise any rights and remedies available to it, including,

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without limitation, those rights and remedies available hereunder, under any
Transaction Document and/or at law or in equity.

                                   ARTICLE VII

                                   TERMINATION

         SECTION 7.01. TERMINATION DATE

         This Agreement shall terminate on December 31, 2012; PROVIDED, HOWEVER,
that if any payments are required to be made by one of the parties hereunder
after that date, this Agreement shall remain in full force and effect until any
and all such payments have been made in full, and solely for that purpose. In
addition, this Agreement shall sooner terminate if the Purchaser or Seller shall
have exercised its right under Section 5.07(a) and Section 5.07(b),
respectively, with the termination date in that event being the date on which
the Seller completes the repurchase of the Assigned Interests and pays in full
in cash the Repurchase Price or the Seller Option Repurchase Price, as the case
may be, in accordance with the terms therein.

         SECTION 7.02. EFFECT OF TERMINATION.

         In the event of the termination of this Agreement pursuant to Section
7.01, this Agreement shall forthwith become void and have no effect without any
liability on the part of any party hereto or its Affiliates, directors, officers
or stockholders other than the provisions of this Section 7.02 and Sections 8.05
and 8.06 hereof. Nothing contained in this Section 7.02 shall relieve any party
from liability for any breach of this Agreement.

                                  ARTICLE VIII

                                  MISCELLANEOUS

         SECTION 8.01. SURVIVAL.

         (a) All representations and warranties made herein and in any other
Transaction Document, any certificates or in any other writing delivered
pursuant hereto or in connection herewith shall survive the execution and
delivery of this Agreement and the Closing and shall continue to survive
indefinitely. Notwithstanding anything in this Agreement or implied by law to
the contrary, all the agreements contained in Section 5.04, 8.05 and 8.06 shall
survive indefinitely following the execution and delivery of this Agreement and
the Closing and the termination of this Agreement.

         (b) Any investigation or other examination that may have been made or
may be made at any time by or on behalf of the party to whom representations and
warranties are made shall not limit, diminish or in any way affect the
representations and warranties in this Agreement and the other Transaction
Documents, and the parties may rely on the representations and warranties in
this Agreement and the other Transaction Documents irrespective of any
information obtained by them by any investigation, examination or otherwise.

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         SECTION 8.02. SPECIFIC PERFORMANCE.

         Each of the parties hereto acknowledges that the other party will have
no adequate remedy at law if it fails to perform any of its obligations under
this Agreement or any of the other Transaction Documents. In such event, each of
the parties agrees that the other party shall have the right, in addition to any
other rights it may have (whether at law or in equity), to specific performance
of this Agreement.

         SECTION 8.03. NOTICES.

         All notices, consents, waivers and communications hereunder given by
any party to the other shall be in writing (including facsimile transmission)
and delivered personally, by telegraph, telecopy, telex or facsimile, by a
recognized overnight courier, or by dispatching the same by certified or
registered mail, return receipt requested, with postage prepaid, in each case
addressed:

                  if to the Purchaser to:

                  c/o Paul Capital Management, L.L.C.
                  50 California Street
                  Suite 3000
                  San Francisco, California  94111
                  Attention:  Chief Financial Officer
                  Facsimile No. (415) 283-4301

                  with a copy to:

                  Walter Flamenbaum, M.D.
                  Paul Capital Partners
                  99 Park Avenue, Suite 801
                  New York, New York  10016
                  Facsimile No.: (212) 293-2219

                  and

                  Morrison & Foerster LLP
                  1290 Avenue of the Americas
                  New York, New York  10104
                  Attention:  Thomas J. Cassidy, Esq.
                  Facsimile No.: (212) 468-7900

                  if to the Seller to:

                  Gliatech Inc.
                  23420 Commerce Park Road
                  Cleveland, Ohio  44124

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Confidential treatment has been requested for the redacted portions of this
exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                  Attention:  Steven L. Basta
                  Facsimile No.:  (216) 831-4220

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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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                  with a copy to:

                  Jones, Day, Reavis & Pogue
                  901 Lakeside Avenue
                  Cleveland, Ohio  44114
                  Attention:  Patrick J. Leddy, Esq.
                  Facsimile No.:  (216) 579-0212

         or to such other address or addresses as the Purchaser or the Seller
may from time to time designate by notice as provided herein, except that
notices of changes of address shall be effective only upon receipt. All such
notices consents, waivers and communications shall: (i) when posted by certified
or registered mail, postage prepaid, return receipt requested, be effective
three (3) Business Days after dispatch, unless such communication is sent
trans-Atlantic, in which case shall be deemed effective five (5) Business Days
after dispatch, (ii) when telegraphed, telecopied, telexed or facsimiled, be
effective upon receipt by the transmitting party of confirmation of complete
transmission, (iii) when delivered by a recognized overnight courier or in
person, be effective upon receipt when hand delivered.

         SECTION 8.04. SCHEDULES.

         Prior to Seller making any representation or warranty under this
Agreement in connection with the Tranche II Payment or the consummation of any
Subsequent Assigned Interest, Seller shall update its disclosure schedules with
respect to all such representations and warranties made by Seller hereunder this
Agreement. In determining the accuracy of the representations and warranties of
Seller in connection with the Tranche II Payment and/or any Subsequent Assigned
Interest, the representations and warranties of Seller shall be evaluated taking
into account the updated disclosure schedules.

         SECTION 8.05. SUCCESSORS AND ASSIGNS.

         The provisions of this Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns.
Seller shall not be entitled to assign any of its obligations and rights
hereunder or any other Transaction Documents without the prior written consent
of the Purchaser. Purchaser may assign any of its rights hereunder (provided
that (a) Purchaser may not assign its rights under Sections 2.01, 2.03, 5.04,
5.05, 5.11(j)-(m), 5.12 and 6.04 without having obtained the prior written
consent of the Seller, (b) Purchaser may not assign its rights under Section
5.07(a) to the extent that the Purchase Option Event giving rise to such
Purchaser Option Repurchase relates to a Purchase Option Event described in
clause (i) or clause (vii) of the definition of "Purchase Option Event," without
having obtained the prior written consent of the Seller and (c) Purchaser may
not assign its rights under Section 5.02(c) without having obtained the prior
written consent of the Seller, unless the inability to assign the rights granted
under Section 5.02(c) in a securitization would prevent a rating agency from
issuing a rating on a security in such securitization or would cause a rating
agency to downgrade the rating of a security in such securitization) but shall
not be permitted to assign any of its obligations hereunder without the prior
written consent of the Seller; PROVIDED, HOWEVER, that

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Purchaser shall not require the written consent of Seller to assign any of its
obligations under Section 2.03 hereof to any affiliate of Purchaser; PROVIDED
FURTHER that Purchaser shall, notwithstanding any assignment to an affiliate of
its obligations under Section 2.03, remain primarily liable hereunder for
performance of any such obligations.

         SECTION 8.06. INDEMNIFICATION.

         (a) Seller hereby indemnifies and holds the Purchaser and its
Affiliates and any of their respective partners, directors, managers, officers,
employees and agents (each a "PURCHASER INDEMNIFIED PARTY") harmless from and
against any and all Losses incurred or suffered by any Purchaser Indemnified
Party arising out of any breach of any representation, warranty or certification
made by the Seller in any of the Transaction Documents or certificates given by
the Seller in writing pursuant hereto or thereto or any breach of or default
under any covenant or agreement by the Seller pursuant to this Agreement or any
Transaction Document, including any failure by the Seller to satisfy any of the
Excluded Liabilities and Obligations.

         (b) The Purchaser hereby indemnifies and holds the Seller and its
Affiliates and any of its partners, directors, managers, officers, employees and
agents (each a "SELLER INDEMNIFIED PARTY") harmless from and against any and all
Losses incurred or suffered by a Seller Indemnified Party arising out of any
breach of any representation, warranty or certification made by the Purchaser in
any of the Transaction Documents or certificates given by the Purchaser in
writing pursuant hereto or thereto or any breach of or default under any
covenant or agreement by the Purchaser pursuant to this Agreement or any
Transaction Document.

         (c) If any claim, demand, action or proceeding (including any
investigation by any Government Authority) shall be brought or alleged against
an indemnified party in respect of which indemnity is to be sought against an
indemnifying party pursuant to the preceding paragraphs, the indemnified party
shall, promptly after receipt of notice of the commencement of any such claim,
demand, action or proceeding, notify the indemnifying party in writing of the
commencement of such claim, demand, action or proceeding, enclosing a copy of
all papers served, if any; PROVIDED, THAT, the omission to so notify such
indemnifying party will not relieve the indemnifying party from any liability
that it may have to any indemnified party under the foregoing provisions of this
Section 8.06 unless, and only to the extent that, such omission results in the
forfeiture of substantive rights or defenses by the indemnifying party. In case
any such action is brought against an indemnified party and it notifies the
indemnifying party of the commencement thereof, the indemnifying party will be
entitled to participate therein and, to the extent that it may wish, jointly
with any other indemnifying party similarly notified, to assume the defense
thereof, with counsel reasonably satisfactory to such indemnified party (who
shall not, except with the consent of the indemnified party, be counsel to the
indemnifying party), and after notice from the indemnifying party to such
indemnified party of its election so to assume the defense thereof, the
indemnifying party will not be liable to such indemnified party under this
Section 8.06 for any legal or other expenses subsequently incurred by such
indemnified party in connection with the defense thereof other than reasonable
costs of investigation. In any such proceeding, an indemnified party shall have
the right to retain its own counsel, but the reasonable fees and expenses of
such counsel shall be at the expense of such indemnified party unless (i) the

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with the Securities and Exchange Commission.
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indemnifying party and the indemnified party shall have mutually agreed to the
retention of such counsel, (ii) the indemnifying party has assumed the defense
of such proceeding and has failed within a reasonable time to retain counsel
reasonably satisfactory to such indemnified party or (iii) the named parties to
any such proceeding (including any impleaded parties) include both the
indemnifying party and the indemnified party and representation of both parties
by the same counsel would be inappropriate due to actual or potential conflicts
of interests between them based on the advice of such counsel. It is agreed that
the indemnifying party shall not, in connection with any proceeding or related
proceedings in the same jurisdiction, be liable for the reasonable fees and
expenses of more than one separate law firm (in addition to local counsel where
necessary) for all such indemnified parties. The indemnifying party shall not be
liable for any settlement of any proceeding effected without its written
consent, but if settled with such consent or if there be a final judgment for
the plaintiff, the indemnifying party agrees to indemnify the indemnified party
from and against any loss or liability by reason of such settlement or judgment.
No indemnifying party shall, without the prior written consent of the
indemnified party, effect any settlement of any pending or threatened proceeding
in respect of which any indemnified party is or could have been a party and
indemnity could have been sought hereunder by such indemnified party, unless
such settlement includes an unconditional release of such indemnified party from
all liability on claims that are the subject matter of such proceeding.

         SECTION 8.07. EXPENSES.

         Each party hereto will pay all of its own fees and expenses in
connection with entering into and consummating the transactions contemplated by
this Agreement.

         SECTION 8.08. INDEPENDENT NATURE OF RELATIONSHIP.

         (a) The relationship between the Seller and the Purchaser is solely
that of seller and purchaser, and neither the Purchaser nor the Seller has any
fiduciary or other special relationship with the other or any of their
respective Affiliates. Nothing contained herein or in any other Transaction
Document shall be deemed to constitute the Seller and the Purchaser as a
partnership, an association, a joint venture or other kind of entity or legal
form.

         (b) No officer or employee of the Purchaser will be located at the
premises of the Seller or any of its Affiliates, except in connection with an
audit performed pursuant to Section 5.02. No officer or employee of the
Purchaser shall engage in any commercial activity with the Seller or any of its
Affiliates other than as contemplated herein and in the other Transaction
Documents.

         (c) Seller and/or any of its Affiliates shall not at any time obligate
the Purchaser, or impose on the Purchaser any obligation, in any manner or
respect to any Person not a party hereto.

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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         SECTION 8.09. ENTIRE AGREEMENT.

         This Agreement, together with the Exhibits and Schedules hereto (which
are incorporated herein by reference), and the other Transaction Documents
constitute the entire agreement between the parties with respect to the subject
matter hereof and supersede all prior agreements (including the Letter of
Intent), understandings and negotiations, both written and oral, between the
parties with respect to the subject matter of this Agreement. No representation,
inducement, promise, understanding, condition or warranty not set forth herein
has been made or relied upon by either party hereto. None of this Agreement, nor
any provision hereof, is intended to confer upon any Person other than the
parties hereto any rights or remedies hereunder.

         SECTION 8.10. AMENDMENTS; NO WAIVERS.

         (a) This Agreement or any term or provision hereof may not be amended,
changed or modified except with the written consent of the parties hereto. No
waiver of any right hereunder shall be effective unless such waiver is signed in
writing by the party against whom such waiver is sought to be enforced.

         (b) No failure or delay by either party in exercising any right, power
or privilege hereunder shall operate as a waiver thereof nor shall any single or
partial exercise thereof preclude any other or further exercise thereof or the
exercise of any other right, power or privilege. The rights and remedies herein
provided shall be cumulative and not exclusive of any rights or remedies
provided by law.

         SECTION 8.11. INTERPRETATION.

         When a reference is made in this Agreement to Articles, Sections,
Schedules or Exhibits, such reference shall be to an Article, Section, Schedule
or Exhibit to this Agreement unless otherwise indicated. The words "include,"
"includes" and "including" when used herein shall be deemed in each case to be
followed by the words "without limitation." Neither party hereto shall be or be
deemed to be the drafter of this Agreement for the purposes of construing this
Agreement against one party or the other.

         SECTION 8.12. HEADINGS AND CAPTIONS.

         The headings and captions in this Agreement are for convenience and
reference purposes only and shall not be considered a part of or affect the
construction or interpretation of any provision of this Agreement.

         SECTION 8.13. COUNTERPARTS; EFFECTIVENESS.

         This Agreement may be executed in two or more counterparts, each of
which shall be an original, but all of which together shall constitute one and
the same instrument. This Agreement shall become effective when each party
hereto shall have received a counterpart hereof signed by the other party
hereto.

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         SECTION 8.14. SEVERABILITY.

         If any provision of this Agreement is held to be invalid or
unenforceable, the remaining provisions shall nevertheless be given full force
and effect.

         SECTION 8.15. GOVERNING LAW; JURISDICTION.

         (a) THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED, INTERPRETED AND
ENFORCED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT GIVING
EFFECT TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

         (b) ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS AGREEMENT OR
ANY OTHER TRANSACTION DOCUMENT MAY BE BROUGHT IN ANY STATE OR FEDERAL COURT OF
COMPETENT JURISDICTION IN THE STATE, COUNTY AND CITY OF NEW YORK. BY EXECUTION
AND DELIVERY OF THIS AGREEMENT, EACH PARTY HERETO HEREBY IRREVOCABLY CONSENTS TO
AND ACCEPTS, FOR ITSELF AND IN RESPECT OF ITS PROPERTY, GENERALLY AND
UNCONDITIONALLY THE NON-EXCLUSIVE JURISDICTION OF SUCH COURTS. EACH PARTY HERETO
HEREBY FURTHER IRREVOCABLY WAIVES ANY OBJECTION, INCLUDING ANY OBJECTION TO THE
LAYING OF VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, WHICH IT MAY
NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY ACTION OR PROCEEDING IN SUCH
JURISDICTION IN RESPECT OF THIS AGREEMENT OR ANY OTHER TRANSACTION DOCUMENT.

         (c) EACH PARTY HERETO HEREBY IRREVOCABLY CONSENTS TO THE SERVICE OF
PROCESS OUT OF ANY OF THE COURTS REFERRED TO IN SUBSECTION (b) ABOVE OF THIS
SECTION 8.14 IN ANY SUCH SUIT, ACTION OR PROCEEDING BY THE MAILING OF COPIES
THEREOF BY REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO IT AT ITS ADDRESS
SET FORTH IN THIS AGREEMENT. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES ANY
OBJECTION TO SUCH SERVICE OF PROCESS AND FURTHER IRREVOCABLY WAIVES AND AGREES
NOT TO PLEAD OR CLAIM IN ANY SUIT, ACTION OR PROCEEDING COMMENCED HEREUNDER OR
UNDER ANY OTHER TRANSACTION DOCUMENT THAT SERVICE OF PROCESS WAS IN ANY WAY
INVALID OR INEFFECTIVE. NOTHING HEREIN SHALL AFFECT THE RIGHT OF A PARTY TO
SERVE PROCESS ON THE OTHER PARTY IN ANY OTHER MANNER PERMITTED BY LAW.

         SECTION 8.16. APPOINTMENT OF AUTHORIZED AGENT.

         Seller hereby designates and appoints CT Corporation, 111 Eighth
Avenue, 13th Floor, New York, New York 10011, as its authorized agent to accept
and acknowledge on its behalf service of any and all process which may be served
in any suit, action or proceeding in

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connection with this Agreement or any other Transaction Document. Seller hereby
agrees that service of process upon said agent at said address and written
notice of said service of Seller, mailed or delivered to Seller, in the manner
provided herein shall be deemed in every respect effective service of process
upon the grantor in any such suit, action or proceeding. Seller (a) shall give
prompt written notice to the Purchaser of any changed address of its authorized
agent hereunder, (b) may, with the prior written consent of the Purchaser,
designate a substitute authorized agent with an office in New York, New York
(which office shall be designated as the address for service of process), and
(c) shall promptly designate such a substitute if its authorized agent ceases to
have an office in New York, New York or is dissolved without leaving a
successor.

         SECTION 8.17. WAIVER OF JURY TRIAL.

         EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT
PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY ACTION,
PROCEEDING, CLAIM OR COUNTERCLAIM ARISING OUT OF OR RELATING TO THIS AGREEMENT
OR ANY OTHER TRANSACTION DOCUMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY OR
THEREBY. THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS,
SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT OR ANY OTHER TRANSACTION
DOCUMENT.

         SECTION 8.18 ADDITIONAL AGREEMENT.

         Notwithstanding anything contained herein this Agreement to the
contrary, in no event shall Seller be considered to be in breach of any
representation, warranty, covenant or agreement, nor shall Purchaser have any
right to terminate this Agreement or exercise its Purchase Option, [***]. The
parties acknowledge that Seller intends to use the proceeds from the sale of the
Assigned Interests, together with funds on hand, to fund operating expenses and
for working capital purposes on a going forward basis, and that it is
anticipated that Seller's cash and cash equivalents and short term investments
balances [***].

                                   ARTICLE IX

                                   [RESERVED]

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exhibit, and such confidential portions have been omitted and filed separately
with the Securities and Exchange Commission.
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         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed by their respective authorized officers as of the date first above
written.

SELLER:                        GLIATECH INC.

                               By:   /s/ Steven L. Basta
                                  --------------------------------
                                        Name:  Steven L. Basta
                                        Title: President

PURCHASER:                     PAUL CAPITAL ROYALTY ACQUISITION FUND, L.P.

                               By:      Paul Capital Management, LLC,
                                        its General Partner

                               By:   /s/ Walter Flamenbaum
                                  --------------------------------
                                        Name:  Walter Flamenbaum, M.D.
                                        Title: Managing Member

                    [SIGNATURE PAGE TO ASSIGNMENT AGREEMENT]

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<TABLE>
<CAPTION>

                             EXHIBITS AND SCHEDULES

<S>                                      <C>
         EXHIBITS

         Exhibit A                          Projected Net Sales
         Exhibit B                          1999 and 2000 Financial Statements of Seller
         Exhibit C                          Form of Bill of Sale
         Exhibit D                          Form of Security Agreement
         Exhibit E                          Reserved
         Exhibit F                          Form of Legal Opinion of Counsel to the Seller
         Exhibit G                          Form of Warrant
         Exhibit H                          Conditions to Payments of the Remaining Tranche I
                                            Payment Pursuant to Section 6.04(a)
         Exhibit I                          Additional Closing Conditions Pursuant to Section 6.04(b)

         SCHEDULES

         Schedule A                         Adcon Technology
         Schedule B                         Material Adverse Change
         Schedule 3.02                      Corporate Authorization
         Schedule 3.03                      Governmental Authorizations
         Schedule 3.04                      Ownership
         Schedule 3.06                      Undisclosed Liabilities
         Schedule 3.08                      Litigation
         Schedule 3.09                      Compliance with Laws
         Schedule 3.10                      Conflicts
         Schedule 3.12(a)                   List of Patents and Trademarks Owned by the Company
         Schedule 3.12(b)                   Intellectual Property (Agreements)
         Schedule 3.12(c)                   Intellectual Property (Violations of Agreements)
         Schedule 3.12(e)                   Intellectual Property (Title)
         Schedule 3.12(f)                   Existing Distribution Agreements (Authority)
         Schedule 3.12(g)                   Intellectual Property (Unpaid Fees)
         Schedule 3.12(h)                   Material Non-Compliance with Applicable Patent Office
                                            Duties of Candor and Good Faith
         Schedule 3.12(i)                   Intellectual Property (Payments)
         Schedule 3.12(j)                   Right to Payments
         Schedule 3.12(k)                   Claims and Proceedings Relating to Patents and Intellectual
                                            Property
         Schedule 3.12(l)                   Governmental Investigations
         Schedule 3.13(a)                   Regulatory Approval
         Schedule 3.13(b)                   Status of Worldwide Applications
         Schedule 3.15                      Subordination
</TABLE>

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with the Securities and Exchange Commission.
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<TABLE>
<CAPTION>
<S>                                      <C>

         Schedule 3.16                      Place of Business
         Schedule 3.18                      Other Information
         Schedule 3.19(a)                   Effectiveness of Distribution Agreements
         Schedule 3.19(b)                   Correspondence Regarding Distribution Agreements
         Schedule 3.19(b)(v)                Payments Required to be Made Under Distribution
                                            Agreements
         Schedule 3.20                      Insurance Policies
         Schedule 5.11(j)                   Adcon-Related Job Openings
         Schedule 6.02(g)                   List of Filing Offices
</TABLE>

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with the Securities and Exchange Commission.
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                                TABLE OF CONTENTS
<TABLE>
<CAPTION>

<S>                                                                                                          <C>
ARTICLE I             DEFINITIONS................................................................................1

         Section 1.01.         Definitions.......................................................................1

ARTICLE II            PURCHASE AND SALE OF ASSIGNED INTERESTS...................................................13

         Section 2.01.         Purchase and Sale................................................................13

         Section 2.02.         Payments in Respect of the Assigned Interest.....................................14

         Section 2.03.         Purchase Price...................................................................16

         Section 2.04.         No Assumed Obligations...........................................................16

ARTICLE III REPRESENTATIONS AND WARRANTIES OF SELLER............................................................16

         Section 3.01.         Organization.....................................................................17

         Section 3.02.         Corporate Authorization..........................................................17

         Section 3.03.         Governmental Authorization.......................................................17

         Section 3.04.         Ownership........................................................................17

         Section 3.05.         Financial Statements.............................................................18

         Section 3.06.         No Undisclosed Liabilities.......................................................18

         Section 3.07.         Solvency.........................................................................18

         Section 3.08.         Litigation.......................................................................18

         Section 3.09.         Compliance with Laws.............................................................19

         Section 3.10.         Conflicts........................................................................19

         Section 3.11.         Material Contracts...............................................................20

         Section 3.12.         Intellectual Property............................................................20

         Section 3.13.         Regulatory Approval..............................................................22

         Section 3.14.         Transfer of IP Rights............................................................23

         Section 3.15.         Subordination....................................................................23

         Section 3.16.         Place of Business................................................................23

         Section 3.17.         Broker's Fees....................................................................23

         Section 3.18.         Other Information................................................................23

         Section 3.19.         Distribution Agreements..........................................................23

         Section 3.20.         Insurance........................................................................25
</TABLE>

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with the Securities and Exchange Commission.
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                                TABLE OF CONTENTS

<TABLE>
<CAPTION>

<S>                                                                                                          <C>

ARTICLE IV            REPRESENTATIONS AND WARRANTIES OF THE PURCHASER...........................................25

         Section 4.01.         Organization.....................................................................25

         Section 4.02.         Authorization....................................................................26

         Section 4.03.         Broker's Fees....................................................................26

         Section 4.04.         Conflicts........................................................................26

         Section 4.05.         Consents.........................................................................26

         Section 4.06.         Financial Capacity...............................................................26

         Section 4.07.         Experience; Accredited Investor Status...........................................27

ARTICLE V             COVENANTS.................................................................................27

         Section 5.01.         Consents and Waivers.............................................................27

         Section 5.02.         Access; Books and Records........................................................27

         Section 5.03.         Material Contracts...............................................................28

         Section 5.04.         Confidentiality; Public Announcement.............................................28

         Section 5.05.         Right of First Refusal...........................................................29

         Section 5.06.         Quarterly Reports................................................................30

         Section 5.07.         Purchase Options.................................................................30

         Section 5.08.         Security Agreement...............................................................31

         Section 5.09.         Commercially Reasonable Efforts; Further Assurance...............................31

         Section 5.10.         Remittance to Lockbox Account....................................................32

         Section 5.11.         Seller's Additional Covenants....................................................33

         Section 5.12.         Future Agreements................................................................37

         Section 5.13.         Seller's Post-Closing Deliveries.................................................38

         Section 5.14.         Licensing Agreement..............................................................38

         Section 5.15.         Retention of President...........................................................39

         Section 5.16.         Additional Purchaser Covenant....................................................39

ARTICLE VI            THE CLOSING; CONDITIONS TO CLOSING AND FUNDING............................................39

         Section 6.01.         The Closing......................................................................39

         Section 6.02.         Conditions Applicable to the Purchaser...........................................39
</TABLE>

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with the Securities and Exchange Commission.
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                                TABLE OF CONTENTS

<TABLE>
<CAPTION>

<S>                                                                                                          <C>

         Section 6.03.         Conditions Applicable to the Seller..............................................41

         Section 6.04.         Conditions to Payments of the Remaining Tranche I Payment, the Tranche II
                               Payment and the Subsequent Purchase Prices.......................................42

         Section 6.05.         Funding Termination Event........................................................43

ARTICLE VII           TERMINATION...............................................................................43

         Section 7.01.         Termination Date.................................................................43

         Section 7.01.Termination Date..........................................................................43

         Section 7.02.         Effect of Termination............................................................43

ARTICLE VIII          MISCELLANEOUS.............................................................................43

         Section 8.01.         Survival.........................................................................43

         Section 8.02.         Specific Performance.............................................................44

         Section 8.03.         Notices..........................................................................44

         Section 8.04.         Schedules........................................................................46

         Section 8.05.         Successors and Assigns...........................................................46

         Section 8.06.         Indemnification..................................................................47

         Section 8.07.         Expenses.........................................................................48

         Section 8.08.         Independent Nature of Relationship...............................................48

         Section 8.09.         Entire Agreement.................................................................49

         Section 8.10.         Amendments; No Waivers...........................................................49

         Section 8.11.         Interpretation...................................................................49

         Section 8.12.         Headings and Captions............................................................49

         Section 8.13.         Counterparts; Effectiveness......................................................49

         Section 8.14.         Severability.....................................................................50

         Section 8.15.         Governing Law; Jurisdiction......................................................50

         Section 8.16.         Appointment of Authorized Agent..................................................50

         Section 8.17.         Waiver of Jury Trial.............................................................51

ARTICLE IX            [RESERVED]................................................................................51
</TABLE>

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