Document:

Sublease, Alkermes, Inc.

 Exhibit 10.20 
 SUBLEASE AGREEMENT 
 THIS SUBLEASE
AGREEMENT (this “Sublease”), is hereby entered into as of this 2nd day of September, 2008, by and between ALKERMES, INC., a Pennsylvania corporation, having an address at 88 Sidney Street, Cambridge, Massachusetts 02139-4211 (“Sublessor”), and AVEO
PHARMACEUTICALS, INC., a Delaware corporation, having a mailing address at 75 Sidney Street, Cambridge, Massachusetts 02139-4211 (“Sublessee”). 
 WHEREAS, FC 64 SIDNEY, INC., a Massachusetts corporation (f/k/a Forest City 64 Sidney Street, Inc.) (“Landlord”) and Sublessor entered into that certain Lease dated October 26, 2000, as
amended by that certain First Amendment to Lease dated as of April 2002 (collectively, the “Prime Lease”), a copy of which is attached hereto as Exhibit A, pursuant to which Landlord leases to Sublessor premises located on the
first, third, fourth and fifth floors of the building located at 64 Sidney Street, Cambridge, Massachusetts (the “Building”), said premises consisting of approximately 64,973 rentable square feet, as more fully described in the Prime Lease
(the “Premises”); and 
 WHEREAS, Sublessor desires to sublease to Sublessee and Sublessee desires to sublease from
Sublessor a portion of the Premises located on the first floor and consisting of 7,407 rentable square feet (the “Subleased Premises”) as shown on Exhibit B attached hereto. 
 NOW, THEREFORE, in consideration of the mutual covenants contained herein, the receipt and sufficiency of which are hereby acknowledged,
Sublessor and Sublessee, intending to be legally bound hereby, covenant and agree as follows: 
 1. Subleased Premises.
Sublessor hereby subleases to Sublessee, and Sublessee hereby subleases from Sublessor, the Subleased Premises. Sublessee shall have, as appurtenant to the Subleased Premises, the appurtenant rights set forth in Sections 2.2(a) and (b) of the
Prime Lease. 
 2. Condition of the Subleased Premises. Sublessor shall deliver and Sublessee shall accept the Subleased
Premises in its “AS IS” condition existing as of the date of this Sublease, in broom clean condition, with all life-safety, mechanical (including HVAC), electrical, and plumbing systems serving the Subleased Premises (collectively, the
“Systems”) in good operating condition and repair, and with all personal property removed. Except as set forth in this Section 2, Sublessor will not be required to make, or pay for, any alterations, improvements, repairs or
decorations to the Subleased Premises prior to their delivery to Sublessee hereunder. 
 3. Term of Sublease. Subject to
the provisions of Section 13.u below, the term of this Sublease (the “Term”) shall commence on the date Sublessor delivers possession of the Subleased Premises to Sublessee in the condition set forth in Section 2 hereof free of
all tenants and occupants (the “Sublease Commencement Date”), which is anticipated to occur on the date Landlord executes and delivers its consent to this Sublease (the “Anticipated Sublease Commencement Date”) and shall expire
on April 30, 2012 (the “Sublease Expiration Date”) unless sooner terminated as hereinafter provided. If the Sublease Commencement Date has not occurred

 
on or before thirty (30) days after the Anticipated Sublease Commencement Date, Sublessee shall have the right to terminate this Sublease by written notice to Sublessor to be delivered no
later than ten (10) days after the expiration of such 30-day period, in which case Sublessor shall promptly return the full amount of the Security Deposit to Sublessee; provided, however, that if the Sublease Commencement Date shall occur
before any such Sublessee notice, Sublessee shall not thereafter have the right to so terminate this Sublease. 
 4.
Rent. 
  

	 	a.	Annual Fixed Rent. The annual rent (“Annual Rent”) for the Subleased Premises will be: 

  

	 	i.	For Year 1: Two Hundred Nineteen Thousand Six Hundred Seventeen and 55/100 Dollars ($219,617.55), payable in equal monthly installments of Eighteen Thousand
Three Hundred One and 46/100 Dollars ($18,301.46); 

  

	 	ii.	For Year 2: Two Hundred Twenty Seven Thousand Twenty Four and 55/100 Dollars ($227,024.55), payable in equal monthly installments of Eighteen Thousand Nine
Hundred Eighteen and 71/100 Dollars ($18,918.71); 

  

	 	iii.	For Year 3: Two Hundred Thirty Four Thousand Four Hundred Thirty One and 55/100 Dollars ($234,431.55), payable in equal monthly installments of Nineteen Thousand
Five Hundred Thirty Five and 96/100 ($19,535.96); 

  

	 	iv.	For Year 4 (partial year): Two Hundred Forty One Thousand Eight Hundred Thirty Eight and 55/100 Dollars ($241,838.55), payable in equal monthly installments of
Twenty Thousand One Hundred Fifty Three and 21/100 Dollars ($20,153.21). 

 The Annual Rent shall be payable in
advance, without any previous demand therefor, in equal monthly installments as set forth above, on the first day of each month during the Term, except that (i) with respect to Year 1 (as defined below), no Annual Rent shall be due until the
date that is six weeks after the Sublease Commencement Date (the “Rent Commencement Date”) and only for the portion of the Term from and after the Rent Commencement Date and (ii) with respect to Year 4, Annual Rent shall be pro rated
for such partial year. If the Rent Commencement Date falls on a day other than the first day of the month, then the Annual Rent due with respect to such month of the Term shall be prorated, and if the Sublease Expiration Date falls on a day other
than the last day of the month, then the Annual Rent due with respect to such month of the Term shall be prorated. Checks for the Annual Rent shall be made payable to Alkermes, Inc. and mailed to 88 Sidney Street, Cambridge, Massachusetts 02139 to
the attention of Accounts Receivable. 
  

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 For purposes of this Sublease, “Year 1” shall be the 12 months commencing on the
Sublease Commencement Date and ending on the day immediately preceding the first anniversary of the Sublease Commencement Date. Each subsequent “Year” shall commence on the day immediately following the expiration of the preceding Year and
shall expire on the day immediately preceding the anniversary of such commencement (except for Year 4 which is a partial year and shall expire on the Sublease Expiration Date). 
  

	 	b.	Additional Rent: 

  

	 	i.	Commencing on the Rent Commencement Date, Sublessee shall pay to Sublessor, as additional rent, Sublessee’s Allocable Share (as hereinafter defined) of the amount
of “Tenant’s Tax Expense Allocable to the Premises” (as defined in the Prime Lease) and the amount of the “Tenant’s Operating Expenses Allocable to the Premises” (as defined in the Prime Lease). Such amounts shall be
due and payable in the time and in the manner set forth in the Prime Lease. As of the date hereof, the parties agree that Sublessee’s “Allocable Share” is 11.40% (7,407 rentable square feet of the Subleased Premises divided by 64,973
rentable square feet of the Premises). In connection with the payment of such amounts, Sublessor shall submit to Sublessee any statements of Real Estate Taxes and Operating Expenses (as those terms are defined in the Prime Lease) that Sublessor
receives from Landlord. Sublessee shall be entitled to Sublessee’s Allocable Share of any refunds, abatements or credits provided to Sublessor by Landlord under the Prime Lease on account of any overpayment of Real Estate Taxes or Operating
Expenses. 

  

	 	ii.	During the Term, Sublessee shall pay directly to the utility provider, on or before the due date thereof, all electricity charges reflected on the separate meter
serving only the Subleased Premises. 

  

	 	c.	Interest; Late Payments. Sublessee shall pay interest from the date due, at an annual rate equal to the annual rate from time to time announced by Bank of
America as its base rate, plus two percent (2%), or if such rate can no longer be determined, the annual prime rate from time to time announced by The Wall Street Journal, plus two percent (2%). In addition, Sublessee shall pay to Sublessor a
late payment in an amount equal to the lesser of two percent (2%) of the amount due or $500 for any amount not received by Sublessor within ten (10) days after such payment was due. 

 5. Security Deposit. Simultaneously with the execution of this Sublease Sublessee shall pay to Sublessor in United States currency a
security deposit in the amount of $55,392.00 (the “Security Deposit”), to be retained throughout the Term by Sublessor as security for the payment by Sublessee of the rent herein agreed to be paid and for the faithful performance by
Sublessee of the covenants contained in this Sublease. In lieu of providing cash, Sublessee may provide such Security Deposit in the form of an unconditional, irrevocable standby letter of credit with a term of not less than one (1) year to be
deposited with Sublessor, in the amount of the Security Deposit, which letter of credit shall be in form and substance, and issued by a lending institution, reasonably

  

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acceptable to Sublessor. Sublessee shall deliver to Sublessor a replacement letter of credit not later than thirty (30) days before the expiration of any current letter of credit on deposit
with Sublessor, and the failure to do so (or upon receipt of notice from the issuer of any such letter of credit that it will not be renewed for another one (1) year period) shall constitute an immediate Event of Default hereunder and, in
addition to all other remedies available to Sublessor, Sublessor shall be entitled to draw on the letter of credit and hold the proceeds as cash security. If, following the posting of the Security Deposit, at any time there exists an Event of
Default beyond any applicable notice and cure period, Sublessor shall be entitled, in its sole discretion, to use the Security Deposit or so much thereof as may be necessary in payment of (a) any rent and/or additional rent for the payment of
which Sublessee shall then be in default beyond any applicable notice and cure period, (b) any expense incurred by Sublessor in curing any such default, and (c) any damages, costs or expenses (including reasonable attorneys’ fees)
incurred by Sublessor in connection with the default or in causing Sublessee to restore and refund the portion of the Security Deposit so used or applied by Sublessor. Unless otherwise required by law, the Security Deposit shall not be required to
be segregated from the other funds of Sublessor and no interest shall be paid by Sublessor to Sublessee with respect to the Security Deposit. In the event Sublessor must utilize the Security Deposit, or any portion thereof, for the purposes
permitted under this Section, Sublessee shall restore same to Sublessor within ten (10) days of its receipt of Sublessor’s written demand therefor. Any portion of the Security Deposit which shall not be utilized by Sublessor for any
purpose permitted under this Section shall be returned to Sublessee within thirty (30) days following the expiration of this Sublease and surrender of possession as provided herein. Failure to pay or restore the Security Deposit within the
respective time periods set forth herein shall constitute an Event of Default, in which event, in addition to the remedies available to Sublessor pursuant to this Sublease, Sublessor, in its absolute discretion, may refuse to permit Sublessee to
enter the Subleased Premises. 
 6. Parking. As of the Sublease Commencement Date, Sublessee will not, and will not be
required to, sublease from Sublessor any parking spaces pursuant to this Sublease. 
 7. Services Provided by Sublessor and
Landlord. Sublessor will be responsible for the repair and maintenance of the Systems and Tenant’s Dedicated Mechanical Systems (as that term is defined in the Prime Lease) during the Term and shall keep the same in good operating condition
and repair throughout the Term. Sublessee will reimburse Sublessor for all such repair and maintenance costs (but not any replacement costs) as additional rent within twenty (20) days after Sublessor’s invoice therefor. Notwithstanding
Section 9(b) below, but subject to the consent of Landlord (if applicable), Sublessee may install and maintain, at its sole cost and expense and without Sublessor’s consent, a card key reader access security system at the Subleased
Premises. Except as set forth in this Section 7, Sublessor shall have no other obligation to provide any services of any nature whatsoever to Sublessee or to the Subleased Premises during the Term or to perform the terms, covenants, conditions
or obligations contained in the Prime Lease on the part of Landlord to be performed. However, Sublessor shall use due diligence and all commercially reasonable efforts to cause Landlord to provide to and for the benefit of Sublessee and the
Subleased Premises each and all of the services and obligations which Landlord is required to provide to and for the benefit of the Sublessor and the Subleased Premises pursuant to the terms and provisions of the Prime Lease. Provided Sublessor
makes such efforts, Sublessor shall have no liability to Sublessee if Landlord fails to provide such services in any manner or to any degree, but nothing in the foregoing shall be deemed to exculpate or otherwise

  

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release Sublessor from, or prevent Sublessee from looking directly to Sublessor for, any liability arising out of the failure of Sublessor to perform its express obligations thereunder; nor shall
the foregoing relieve Sublessor of its express obligations set forth in this Sublease. In no event will Sublessee be allowed any abatement or diminution of rent under this Sublease because of Landlord’s failure to perform any of its obligations
under the Prime Lease unless an abatement is available to Sublessor under the Prime Lease. Sublessor hereby covenants and agrees that so long as Sublessee makes timely payments of Annual Rent and additional rent payable hereunder, Sublessor shall
make timely payments of all Annual Fixed Rent and all other charges due Landlord under the Prime Lease. If as a result of any default by Landlord as landlord under the Prime Lease, Sublessor as tenant under the Prime Lease is entitled to any offset
or similar rights against Landlord, Sublessee shall be entitled to a fair and equitable share of such offset or similar rights. Sublessor shall not do, nor permit to do or be done, anything that would cause the Prime Lease to be cancelled,
terminated or forfeited. 
 8. Use. The Subleased Premises shall be used and occupied solely for the uses permitted under
the Prime Lease and for no other purpose (the “Permitted Uses”). 
 9. Maintenance; Alterations. 
  

	 	a.	Sublessee shall maintain the Subleased Premises (except for the Systems and any Tenant’s Dedicated Mechanical Systems) in good, clean, safe and orderly condition
throughout the Term, normal wear and tear and casualty excepted, and shall comply with all requirements of the Prime Lease (to the extent incorporated herein pursuant to Section 14 below) applicable to the Sublease or the Subleased Premises,
including, without limitation, the requirements of Articles 4 and 5 thereof. 

  

	 	b.	 Sublessee, at its sole expense, will be responsible for all costs relating to the construction of any Sublessee leasehold alterations or additions,
including, but not limited to, costs for preparation of architectural, mechanical, electrical, and plumbing engineering plans, and specialty engineering, architectural, contractor and construction services (which such services would not require
Landlord or Sublessor coordination, overhead or contractor supervision fees). Except as otherwise permitted under Section 4.1 of the Prime Lease to the extent incorporated herein pursuant to Section 14 below, Sublessee shall not make
alterations or additions to the Subleased Premises without prior written approval by Sublessor and Landlord, which approval of Sublessor shall not be unreasonably withheld, conditioned or delayed. Sublessee agrees to pay promptly when due the entire
cost of any work done on the Subleased Premises by Sublessee, its agents, employees or independent contractors, and not to cause or permit any liens for labor or materials performed or furnished in connection therewith to attach to the Subleased
Premises or the Building or the real property on which the Building is located and promptly to discharge or bond over any such liens which may so attach. If any such lien shall be filed against the Subleased Premises, the Building or the real
property on which the Building is located and the Sublessee shall fail to cause such lien to be discharged, or bonded over, within fifteen (15) days after receipt by Sublessee of written notice of the filing thereof,

  

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Landlord and/or Sublessor, not sooner than five (5) days after providing additional written notice, may cause such lien to be discharged by payment, bond or otherwise without investigation
as to the validity thereof or as to any offsets or defenses which Sublessee may have with respect to the amount claimed. Sublessee shall reimburse Landlord or Sublessor, as applicable, as additional rent, for any cost so incurred and shall indemnify
and hold harmless Landlord and Sublessor from and against any and all claims, costs, damages, liabilities and expenses (including reasonable attorneys’ fees) which may be incurred or suffered by Landlord and/or Sublessor by reason of any such
lien or its discharge. 

 10. Sublessee’s Covenants. Sublessee covenants during the Term:

  

	 	a.	to pay when due all Annual Rent, additional rent and other charges; 

  

	 	b.	to keep the Subleased Premises (exclusive of the Systems and Tenant’s Dedicated Mechanical Systems) in the same order, repair and condition as of the date
Sublessor delivers the Subleased Premises to Sublessee, reasonable wear and tear and damage by fire or other casualty only excepted, including, without limitation, all glass and doors within the Subleased Premises, and replace all of the same with
glass and material of the same quality as that injured or broken, and, at the expiration or termination of this Sublease, peaceably to yield up the Subleased Premises and all alterations and additions thereto in the same order, repair and condition
as of the date Sublessor delivered the Subleased Premises to Sublessee, reasonable wear and tear and damage by fire or other casualty excepted, first removing all personal property, including telephone equipment, goods and effects of Sublessee,
together with any furniture (including, but not limited to, modular furniture and bookshelves) or fixtures attached to the Subleased Premises by Sublessee, and Sublessee shall repair any damage caused by such removal. Landlord and/or Sublessor may
require removal by the Sublessee of all or any portion of any alterations and additions made to the Subleased Premises, so long as Landlord or Sublessor, as applicable, advises Sublessee of such requirement, in writing, prior to the installation of
the alteration or addition by Sublessee. If Sublessee fails to inform Landlord and Sublessor, in writing, at least fifteen (15) days prior to the installation of the alteration or addition, thereby preventing Landlord and/or Sublessor from
making a determination as to whether it will want such addition or alteration removed from the Subleased Premises prior to its installation, then Landlord and Sublessor shall advise Sublessee in writing of such determination within fifteen
(15) days after Sublessee gives Landlord and Sublessor written notice requesting that Landlord and Sublessor make such determination. In the event of such removal, Sublessee shall repair any damage caused by such removal, and Sublessee shall
leave the Subleased Premises broom clean and neat; 

  

	 	c.	to use and occupy the Subleased Premises only for the Permitted Uses; 

  

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	 	d.	not to injure or deface the Subleased Premises or the Building; nor to permit in the Subleased Premises any flammable fluids or chemicals, or nuisance, or hazardous
substances in amounts in violation of any law, or the emission from the Subleased Premises of any objectionable noise or odor, nor to use or devote the Subleased Premises or any part thereof for any purpose other than the Permitted Uses, nor any use
thereof which is inconsistent with the standards of the Building, or which is contrary to law or ordinance or liable to invalidate or increase the premiums for any insurance on the Building or its contents (unless Sublessee agrees to pay for such
increased costs) or liable to render necessary any alteration or addition to the Building; 

  

	 	e.	 not to assign, mortgage, pledge or otherwise transfer this Sublease or to make any sublease, or to permit occupancy of the Subleased Premises or any
part thereof by anyone other than Sublessee, without the prior written consent of Landlord and Sublessor not be unreasonably withheld, conditioned or delayed. In the event Sublessee sublets or assigns all or a portion of the Subleased Premises to
any entity other than an Affiliate or Acquiring Company, Sublessor will be entitled to fifty percent (50%) of the resulting sublease or assignment profits, after deduction of all costs associated with such sublet or assignment, including, but
not limited to, Sublessee improvements, brokerage fees, rental concessions, legal fees and architectural and engineering fees. A transfer by operation of law, whether by execution, insolvency or bankruptcy, merger or otherwise, shall be deemed to be
an unauthorized transfer within the meaning of this clause (e). Notwithstanding the foregoing, Sublessee shall have the right to assign or otherwise transfer this Sublease or to make any sublease of all or a portion of the Subleased Premises without
obtaining the prior written consent of Sublessor (but still subject to the prior written consent of Landlord, if required) (i) to an entity owning a majority of Sublessee or to a majority owned subsidiary or to an entity which is majority owned
by the same entity which owns a majority of Sublessee (an “Affiliate”), provided that (A) the transferee shall, subject to applicable law, regulation or prior binding agreement, prior to the effective date of the transfer, deliver to
Sublessor instruments evidencing such transfer and its agreement to assume and be bound by all the terms, conditions and covenants of this Sublease to be performed by Sublessee, all in form reasonably acceptable to Sublessor, and (B) at the
time of such transfer there shall not be any Events of Default hereunder beyond any applicable notice and cure period; or (ii) to the purchaser of at least 50% of its assets or stock, or to any entity into which the Sublessee may be merged or
consolidated (along with all or substantially all of its assets) (the “Acquiring Company”), provided that (A) the net worth of the Acquiring Company upon the consummation of the transfer or merger shall not be less than the net worth
of the Sublessee at the time immediately prior to such transfer or merger, (B) the Acquiring Company continues to operate the business conducted in the Subleased Premises consistent with the permitted use of the Subleased Premises, (C) the
Acquiring Company shall assume in writing, in form reasonably acceptable to Sublessor, all of Sublessee’s obligations under this Sublease, (D) Sublessee shall provide to Sublessor such additional information regarding the Acquiring Company
as Sublessor shall reasonably request, and (E) Sublessee shall pay Sublessor’s reasonable

  

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out-of-pocket expenses, incurred in connection therewith. Whether or not Sublessor consents, or is required to consent, to any assignment or other transfer of this Sublease or to any sublease of
the Subleased Premises, Sublessee shall remain fully and primarily liable for the obligations of Sublessee hereunder, including, but not limited to, the obligation to pay Annual Rent and additional rent provided under this Sublease;

  

	 	f.	Intentionally omitted; 

  

	 	g.	to maintain with responsible companies qualified to do business in Massachusetts, and in good standing, (i) commercial general liability insurance against claims
for personal injury, death or property damage (on an occurrence basis) with respect to the business carried on by Sublessee in or from the Subleased Premises and Sublessee’s use and occupancy of the Subleased Premises and other parts of the
Building, with limits which shall be not less than $1,000,000 per occurrence and a $6,000,000 umbrella policy, (ii) “special form” property insurance in an amount to cover 100% of the replacement cost of Sublessee’s personal
property and fixtures in the Subleased Premises, and (iii) workmen’s compensation insurance with statutory limits covering all of Sublessee’s employees working in the Subleased Premises. The issuing insurer with respect any such
policies will endeavor to mail 30-days prior written notice to Sublessor if such policies are to be cancelled, modified or not renewed and Sublessee’s commercial general liability policy shall include Sublessor and Landlord as additional
insureds. Certificates evidencing all such policies, and any renewals thereof, shall be filed with Sublessor; 

  

	 	h.	that all of the furnishings, fixtures, equipment, effects and property of every kind, nature and description of Sublessee and all persons claiming by, through or under
Sublessee which, during the continuance of this Sublease or any occupancy of the Subleased Premises by Sublessee or anyone claiming under Sublessee, may be on the Subleased Premises or elsewhere in the Building, shall be at the sole risk and hazard
of Sublessee; and if the whole or any part thereof shall be destroyed or damaged by fire, water, rain, snow or otherwise, or by the leakage or bursting of water pipes, steam pipes, or other pipes, by theft or from any other cause, no part of said
loss or damage is to be charged to or to be borne by Sublessor or Landlord; 

  

	 	i.	 to permit Sublessor, and Landlord (pursuant to Section 6.5 of the Prime Lease), and their agents to inspect the Subleased Premises at reasonable
times upon at least twenty-four (24) hours prior notice and at anytime in the event of an emergency, and, if Sublessor shall so elect, to make any repairs or replacements Sublessor or Landlord may deem necessary, and in so doing Sublessor shall
use reasonable efforts to avoid unnecessary inconvenience and to minimize interference to Sublessee by reason thereof (including, without limitation, accessing the Subleased Premises outside of normal business hours); to remove, at Sublessee’s
expense, any alterations, additions, signs, curtains, blinds, shades, awnings, aerials, flagpoles or the like not consented to in writing or permitted by or pursuant to this Sublease or otherwise; and to show the Subleased Premises to prospective
tenants during the six (6) month period preceding expiration of the Term, and to prospective

  

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purchasers and mortgagees at any time upon at least twenty-four (24) hours prior notice during the Term, provided that in connection with any such foregoing entry by Sublessor, Sublessee may
provide procedures reasonably designed so as not to jeopardize Sublessee’s trade secrets, proprietary technology or critical business operations, including accompaniment of all such persons by an employee of Sublessee;

  

	 	j.	not to place upon the floors of the Subleased Premises any load which exceeds the safe carrying capacity of the structure as determined by Landlord or Sublessor in
their sole discretion; and not without Landlord’s and Sublessor’s prior written consent, not to be unreasonably withheld, conditioned or delayed, to install or locate or thereafter move or relocate any safe, vault or other heavy equipment
in, about or out of the Subleased Premises except in such manner and at such time as Landlord and Sublessor shall in each instance authorize. Sublessee shall not install any mechanical equipment which causes vibration or noise that may be
transmitted to the Building structure or to any other space in the Building; 

  

	 	k.	to perform routine cleaning of the Subleased Premises, at its expense; 

  

	 	l.	to not install utility electric lines of any sort without the prior written consent of Landlord and Sublessor; 

  

	 	m.	to ensure that any alterations or improvements to the Subleased Premises constructed by Sublessee shall be ADA compliant; 

  

	 	n.	to comply with all of the terms and conditions of the Prime Lease (to the extent incorporated herein pursuant to Section 14 below) with respect to the Subleased
Premises and all common areas as though Sublessee were the Lessee under the Prime Lease, and 

  

	 	o.	to comply with all laws, ordinances, rules or regulations applicable to Sublessee or Sublessee’s use of the Subleased Premises now or hereafter in effect of all
governmental authorities having jurisdiction over the Subleased Premises. 

 11. Events of Default.
Sublessee will be in default under this Sublease upon the occurrence of any of the following events (hereinafter referred to as “Events of Default”): 
  

	 	a.	Sublessee fails to pay any installment of Annual Rent, additional rent or other sum of money within five (5) days after written notice that the same is due and
payable; provided, however, that Sublessor shall not be required to provide such written notice more than two (2) times in any twelve (12) month period; or 

  

	 	b.	Sublessee fails to perform any other obligation hereunder, which failure shall continue unremedied by Sublessee for a period of twenty (20) days after written
notice thereof shall have been given to Sublessee by Sublessor or Landlord (provided, however, that in case of breaches that are not reasonably susceptible to cure within twenty (20) days through the exercise of due diligence, then so long as
Sublessee commences such cure within twenty (20) days and thereafter diligently pursues such cure to completion); or 

  

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	 	c.	Sublessee makes any assignment for the benefit of creditors, commits any act of bankruptcy or files a petition under any bankruptcy or insolvency law; or if such a
petition is filed against Sublessee and is not dismissed within sixty (60) days; or if a receiver or similar officer becomes entitled to Sublessee’s leasehold hereunder and it is not returned to Sublessee within sixty (60) days; or if
such leasehold is taken on execution or other process of law in any action against Sublessee. 

 If an Event of
Default shall occur, then, in any such case, whether or not the Term shall have begun, the Sublessor lawfully may, immediately or at any time thereafter, give notice to the Sublessee specifying the Event of Default and if Sublessor shall so elect in
connection therewith, this Sublease shall come to an end on the date specified therein as fully and completely as if such date were the date herein originally fixed for the expiration of the Sublease Term, and the Sublessee will then quit and
surrender the Subleased Premises to the Sublessor, but the Sublessee shall remain liable as hereinafter provided. 
 12.
Sublessor’s Remedies. Upon the occurrence of an Event of Default, Sublessor, without notice to Sublessee in any instance (except where expressly provided for below or by applicable law), may do any one or more of the following:

  

	 	a.	In the event that this Sublease is terminated, the Sublessee covenants to pay to the Sublessor punctually all the sums (“Periodic Payments”) and perform all
the obligations which the Sublessee covenants in this Sublease to pay and to perform in the same manner and to the same extent and at the same time as if this Sublease had not been terminated, and all of the Sublessor’s expenses in connection
with reletting the Subleased Premises including, without limitation, all repossession costs, brokerage commissions, reasonable fees for legal services and expenses of preparing the Subleased Premises for such reletting. However, the Sublessor may
elect, at any time, to demand in lieu of any further obligations to make Periodic Payments, and payments on account of the Sublessor’s reletting costs thereafter accruing, as compensation, an amount (the “Lump Sum Payment”) equal to
the excess, if any, of the discounted present value of the total rent reserved for the then remainder of the Term over the then discounted present fair rental value of the Subleased Premises for the then remainder of the Term. The discount rate for
calculating such sum shall be the then current rate of United States Treasury securities having a maturity date as close as possible to the end of the Term (had the Sublease not been terminated). In calculating the rent reserved, there shall be
included, in addition to the Annual Rent and all additional rent, the value of all other considerations agreed to be paid or performed by the Sublessee over the remainder of the Term. 

  

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 In calculating the Periodic Payments to be made by the Sublessee under the foregoing
covenant, the Sublessee shall be credited with the net proceeds of any rent obtained by reletting the Subleased Premises, after deducting all the Sublessor’s expenses in connection with such reletting, including, without limitation, all
repossession costs, brokerage commissions, reasonable fees for legal services and expenses of preparing the Subleased Premises for such reletting. The Sublessor may (i) relet the Subleased Premises, or any part or parts thereof, for a term or
terms which may, at the Sublessor’s option, exceed or be equal to or less than the period which would otherwise have constituted the balance of the Term, and may grant such concessions and free rent as the Sublessor in its reasonable commercial
judgment considers advisable or necessary to relet the same and (ii) make such alterations, repairs and improvements in the Subleased Premises as the Sublessor in its reasonable commercial judgment considers advisable or necessary to relet the
same. No action of the Sublessor in accordance with foregoing or failure to relet or to collect rent under any reletting shall operate to release or reduce the Sublessee’s liability. The Sublessor shall be entitled to seek to rent other
properties of the Sublessor prior to reletting the Subleased Premises. 
  

	 	b.	Distrain, collect or bring action for such rent as being in arrears, or file a proof of claim in any bankruptcy or insolvency proceeding for such rent, or institute any
other proceedings, whether similar or dissimilar to the foregoing, to enforce payment thereof. 

  

	 	c.	Terminate this Sublease, in which event Sublessee shall immediately surrender the Subleased Premises to Sublessor, and if Sublessee fails to do so, Sublessor may,
without prejudice to any other remedy which it may have for possession or arrearages in rent, enter upon and take possession of the Subleased Premises and lawfully expel or remove Sublessee and any other person who may be occupying the Subleased
Premises or any part thereof, without being liable for prosecution or any claim for damages therefor, and Sublessee agrees to pay to Sublessor on demand the amount of all loss and damage which Sublessor may suffer by reason of such termination,
whether through inability to relet the Subleased Premises on satisfactory terms or otherwise, including the loss of rental for the remainder of the Term. 

  

	 	d.	Enter upon and take possession of the Subleased Premises and lawfully expel or remove Sublessee and any other person who may be occupying the Subleased Premises or any
part thereof, without being liable for prosecution of any claim for damages therefor, and if Sublessor so elects, relet the Subleased Premises on such terms as Sublessor shall deem advisable and receive the rent therefor, and Sublessee agrees to pay
to Sublessor on demand any deficiency that may arise by reason of such reletting for the remainder of the Term. 

  

	 	e.	 If Sublessee fails to perform any covenant or observe any condition to be performed or observed by Sublessee hereunder or acts in violation of any
covenant or condition hereof beyond any applicable notice and cure period, Sublessor may, but shall not be required to on behalf of Sublessee, perform such covenant and/or take such steps, including entering upon the Subleased Premises, as may be
necessary or appropriate to meet the requirements of any such covenant or condition, and

  

 11 

	 	 
all costs and expenses incurred by Sublessor in so doing, including reasonable legal fees, shall be paid by Sublessee to Sublessor upon demand, plus interest at the rate set forth in
Section 4.c above from the date of expenditure(s) by Sublessor, as additional rent. Sublessor’s proceeding under the rights reserved to Sublessor under this subsection shall not in any way prejudice or waive any rights as Sublessor might
otherwise have against Sublessee by reason of Sublessee’s default. 

  

	 	f.	Exercise any other rights and remedies available to Sublessor at law or in equity. Unless Sublessor delivers to Sublessee written notice of Sublessor’s intent to
terminate this Sublease, (i) no reentry or taking possession of the Subleased Premises by Sublessor; or (ii) forfeiture or waiver of any rent due to Sublessor hereunder; or (iii) forfeiture or waiver of any damages accruing to
Sublessor by reason of the violation of any of the terms, provisions and covenants herein contained, shall be construed as an election on the part of Sublessor to terminate this Sublease. Sublessor’s acceptance of rent following an Event of
Default hereunder shall not be construed as Sublessor’s waiver of such Event of Default. No waiver by Sublessor of any violation or breach of any of the terms, provisions and covenants herein contained shall be deemed or construed to constitute
a waiver of any other violation or default. The loss or damage that Sublessor may suffer by reason of termination of this Sublease or the deficiency from any reletting as provided for above shall include the expense of repossession and any repairs
or remodeling undertaken by Sublessor following possession. Should Sublessor at any time terminate this Sublease for any default, Sublessee shall not be relieved of its liabilities and obligations hereunder, and, in addition to any other remedy
Sublessor may have, Sublessor may recover from Sublessee all damages Sublessor may incur by reason of such default, including the cost of recovering the Subleased Premises and the loss of rental for the remainder of the Term. Sublessee’s
obligations and liabilities under this Sublease shall also survive repossession and reletting of the Subleased Premises by Sublessor pursuant to the foregoing provisions of this subsection. 

  

	 	g.	All rights and remedies of Sublessor and Sublessee herein enumerated shall be cumulative, and none shall exclude any other right or remedy allowed by law. In addition
to the other remedies set forth in this Sublease, Sublessor shall be entitled to the restraint by injunction of the violation or attempted violation of any of the covenants, agreements or conditions of this Sublease. 

 13. Miscellaneous. 
  

	 	a.	If any term of this Sublease, or the application thereof to any person or circumstances, shall, to any extent, be invalid or unenforceable, whether by operation of the
laws of bankruptcy, insolvency or otherwise, the remainder of this Sublease, or the application of such term to persons or circumstances other than those as to which it is invalid or unenforceable, shall not be affected thereby, and each term of
this Sublease shall be valid and enforceable to the fullest extent permitted by law. 

  

 12 

	 	b.	Intentionally deleted. 

  

	 	c.	All rights of Sublessee under this Sublease are subject and subordinate to the terms and conditions of the Prime Lease and to the matters to which the Prime Lease,
including any amendments thereto entered into hereafter is or shall be subordinate, provided, however, Sublessor shall not terminate, amend or modify (nor agree to terminate, amend or modify) the Prime Lease in any way that would increase
Sublessee’s obligations or diminish Sublessee’s rights under this Sublease. 

  

	 	d.	Sublessor shall have no liability whatsoever for any default by Landlord under the Prime Lease. 

  

	 	e.	If for any reason the Prime Lease shall expire or terminate before the Sublease Expiration Date, then this Sublease shall also expire or terminate on the same date that
the Prime Lease expires or terminates. In such event, neither Landlord nor Sublessor shall in any way be responsible or liable to Sublessee for the early termination of this Sublease; provided that, nothing in the foregoing shall be deemed to
exculpate or otherwise release Sublessor from, or prevent Sublessee from looking directly to Sublessor for, any liability arising out of the failure of Sublessor to perform its express obligations under the Prime Lease. 

  

	 	f.	The provisions of this Sublease to the contrary notwithstanding, each party agrees that neither Sublessor nor Sublessee nor any of their respective owners, officers,
directors, agents or employees shall have any personal liability with respect to the provisions of this Sublease and neither Sublessee nor Sublessor nor any person claiming under, by or through Sublessee or Sublessor, as the case may be, shall be
entitled to take any action to procure a money judgment in personam against any person or entity who is an owner, officer, director, agent or employee of Sublessor or Sublessee or any of their respective successors and assigns, heirs or personal
representatives. 

  

	 	g.	If there is any conflict or variance between the provisions of this Sublease and the provisions of the Prime Lease incorporated herein pursuant to Section 14
below, such provisions of the Prime Lease shall supersede the provisions of this Sublease. Unless otherwise provided herein, all capitalized terms used herein shall have the same meaning as set forth in the Prime Lease. 

  

	 	h.	Neither Sublessor nor Sublessee shall be liable to the other party or to any insurance company (by way of subrogation or otherwise) insuring the other party for any
loss or damage to any building, structure or other tangible property, or any resulting loss of income, or losses under workmen’s compensation laws and benefits, even though such loss or damage might have been occasioned by the negligence of
such party, its agents or employees if, and to the extent that, any such loss or damage is covered by insurance benefiting the party suffering such loss or damage or was required to be covered by insurance pursuant to this Sublease.

  

 13 

	 	i.	This Sublease contains all of the agreements of the parties with respect to the subject matter thereof and supersedes all prior dealings between them with respect to
such subject matter. 

  

	 	j.	The headings in this Sublease are for purposes of reference only and shall not limit or define the meanings hereof. 

  

	 	k.	This Sublease and the rights and obligations of the parties hereunder shall be construed in accordance with the laws of the Commonwealth of Massachusetts.

  

	 	l.	Any notice given or to be given under this Sublease shall be in writing and shall be given by United States registered or certified mail, return receipt requested, or
by a nationally recognized overnight delivery service, with all delivery and postage charges prepaid, and shall be deemed to have been given on the date such notice is actually received or refused, or if unclaimed, on the third day following the day
on which the same shall have been sent by a nationally recognized overnight delivery service or deposited with the United States Post Office. Any such communication shall be sent to the respective parties at their address set forth in the first
paragraph of this Sublease or such other address as shall be designated by the receiving party in writing, and with respect to a notice to Sublessee, with a copy to Joseph Vittiglio, Esq., AVEO Pharmaceuticals, 75 Sidney Street, Cambridge, MA
02139-4211. 

  

	 	m.	Neither Sublessor nor Sublessee has dealt with any broker or agent in connection with the negotiation or execution of this Sublease, other than Richards Barry
Joyce & Partners and Colliers Meredith & Grew, whose commissions shall be paid by Sublessor pursuant to a separate written agreement. Sublessee and Sublessor shall each indemnify the other against all costs, expenses, reasonable
attorneys’ fees, liens and other liability for commissions or other compensation claimed by any broker or agent claiming the same by, through, or under the indemnifying party. 

  

	 	n.	Sublessor shall promptly give Sublessee a copy of any (i) notice of default or termination received by, or sent by, Sublessor with respect to the Prime Lease,
(ii) notice otherwise affecting the existence or validity of this Sublease, or (iii) notice relating to any casualty or taking, but only to the extent any of the foregoing affect or relate to the Subleased Premises or this Sublease.

  

	 	o.	Sublessor warrants and represents to Sublessee that (i) a true and correct copy of the Prime Lease (as redacted by Sublessor) is attached hereto as Exhibit
A and the Prime Lease has not since been amended or modified, (ii) Sublessor has not received notice of default of any of the provisions of the Prime Lease, (iii) Sublessor has no actual knowledge of any claim by Landlord that
Sublessor is in default or breach of any of the provisions of the Prime Lease, (iv) to the best of Sublessor’s knowledge Landlord is not in default under the Prime Lease, (v) Sublessor is the tenant under the Prime Lease and has the
full right to enter into this Sublease (subject, however, to Landlord’s consent) and (vi) the Prime Lease is in full force and effect. 

  

 14 

	 	p.	Sublessee will be responsible for any telecommunications or data wiring or modifications to the existing wiring in the Subleased Premises. Subject to the consent of
Landlord (if applicable), Sublessee will have the right to alter or remove the existing telecommunications and data wiring, cabling and equipment racks in the Subleased Premises; provided, however, that (i) Sublessee shall use only
then-existing conduits for any such facilities and equipment and no core drilling shall be allowed in connection therewith, (ii) any such work shall not impact the security and monitoring wires that may be integral with the existing data
wiring, and (iii) Sublessee shall be responsible for all costs which may be necessary on account of, or be necessary for, the installation or, upon the expiration or earlier termination of this Sublease, the removal of any such alterations.

  

	 	q.	Sublessee may connect not more than two twenty (20)-ampere circuit telephone/data equipment (not HVAC system loads) to Sublessor’s emergency generator that
currently services the fourth floor of the Building. 

  

	 	r.	To the extent permitted by Landlord, not to be unreasonably withheld, Sublessee shall have the right to Building standard signage at the entrance to the Subleased
Premises and in the main Building lobby tenant directory. 

  

	 	s.	Subject to Sublessor and Landlord approval, not to be unreasonably withheld, conditioned or delayed, Sublessee may, at its sole expense and at no additional rental
cost, install antennas, satellite dishes and the like on the roof of the Building. 

  

	 	t.	Sublessee will have access to Building freight loading docks and trash compactor at no additional costs, subject to the Building’s rules and regulations in this
regard. 

  

	 	u.	The terms and conditions of this Sublease and the effectiveness thereof, are expressly contingent upon the written approval of Landlord. The terms of Landlord’s
consent to this Sublease shall be reasonably satisfactory to Sublessor and Sublessee. It is expressly understood and agreed that notwithstanding anything to the contrary contained herein, the Term shall not commence, nor shall Sublessee take
possession of the Subleased Premises or any part thereof, until the Landlord’s consent has been obtained. Sublessee hereby agrees that it shall reasonably cooperate in good faith with Sublessor and shall comply with any reasonable requests made
of Sublessee by Landlord in the procurement of such consent. 

  

	 	v.	 Notwithstanding anything to the contrary contained in this Sublease or in the Prime Lease, Sublessee shall not have the right to terminate this
Sublease as to all or any part of the Subleased Premises, or be entitled to an abatement of Annual Rent or any other item of rental, by reason of a casualty or condemnation affecting the Subleased Premises unless Sublessor is entitled to terminate
the Prime Lease or is entitled to a corresponding abatement with respect to its corresponding obligation under the Prime Lease. If Sublessor is entitled to terminate the Prime Lease by reason of casualty

  

 15 

	 	 
or condemnation, Sublessee may terminate this Sublease by written notice to Sublessor given at least ten (10) business days prior to the date(s) Sublessor is required to give notice to Prime
Landlord of such termination under the terms of the Prime Lease (the “Prime Lease Termination Date”), and Sublessor shall notify Sublessee in writing of the Prime Lease Termination Date at least thirty (30) days before such date occurs.

  

	 	w.	Sublessor shall indemnify and save harmless Sublessee from and against all claims, loss or damage of whatever nature arising from (i) any breach by Sublessor of
any obligation under this Sublease or (ii) from any negligence or misconduct of Sublessor, or the Sublessor’s contractors, licensees, agents, servants or employees, provided that the foregoing indemnity shall not include any claims, loss
or damage to the extent arising from any act, omission or negligence of Sublessee or the Sublessee’s contractors, licensees, agents, servants or employees occurring following the Commencement Date and until the expiration or earlier termination
of the Term of this Sublease. 

 Sublessee shall indemnify and save harmless Sublessor from and against all claims,
loss, or damage of whatever nature arising from (i) any breach by Sublessee of any obligation of Sublessee under this Sublease, or (ii) any negligence or misconduct of the Sublessee, or the Sublessee’s contractors, licensees, agents,
servants or employees, or (iii) any accident, injury or damage whatsoever caused to any person or property in the Building or on or about the Land, occurring after the Sublease Commencement Date (or such earlier date upon which the Sublessee
first commences occupancy of all or any part of the Subleased Premises) and until the end of the Term and thereafter, so long as the Sublessee is in occupancy of any part of the Subleased Premises, provided that the foregoing indemnity shall not
include any claims, loss or damage to the extent arising from any negligence or misconduct of the Sublessor, or the Sublessor’s contractors, licensees, agents, servants or employees. 
 The foregoing indemnity and hold harmless agreements shall include indemnity against reasonable attorneys’ fees and all other costs,
expenses and liabilities incurred in connection with any such claim or proceeding brought thereon, and the defense thereof, but shall be subject to the limitations specified in Sections 13.h and 13.y. 
  

	 	x.	Sublessee shall have access to the Subleased Premises 24 hours per day, 7 days per week, 365 days per year. 

  

	 	y.	In no event shall either Sublessor or Sublessee be liable to the other for consequential damages, provided that neither damages incurred by Sublessor in connection with
any holding over by Sublessee in the Subleased Premises, including without limitation those associated with loss, cost, liability or expense arising by virtue of the existence of aggrieved third parties (e.g. lenders and prospective sublessees), nor
damages incurred by Sublessor to Landlord in connection with any default under the Prime Lease caused by Sublessee, shall constitute consequential damages. 

  

 16 

 14. Prime Lease. 
  

	 	a.	This Sublease is in all respects subject and subordinate to the terms and conditions of the Prime Lease and to the matters to which the Prime Lease, including any
amendments thereto, is or shall be subordinate. Sublessee agrees that Sublessee has reviewed and is familiar with the Prime Lease, and will not do or suffer or permit anything to be done which would result in a default or breach (whether or not
subject to notice or grace periods) on the part of Sublessor under the Prime Lease or cause the Prime Lease to be terminated. If, however, the Prime Lease is terminated prior to its scheduled expiration, for any reason whatever, this Sublease shall
likewise terminate without further notice, and, except as otherwise set forth herein, without further obligation or liability on the part of the parties. 

  

	 	b.	Except as otherwise expressly provided in this Sublease, the terms, covenants, conditions, rights, obligations, remedies and agreements of the Prime Lease are
incorporated into this Sublease by reference and made a part hereof as if fully set forth herein and shall constitute the terms of this Sublease, mutatis mutandis, Sublessor being substituted for “Landlord” thereunder,
Sublessee being substituted for “Tenant” thereunder, and “Subleased Premises” being substituted for “Premises” thereunder, except to the extent that such terms do not relate to the Subleased Premises or Sublessee’s
use thereof, or are inapplicable to, or superseded by the terms of this Sublease; except that all references in the following sections and/or provisions of the Prime Lease to “Landlord”, ‘Tenant”, “Lease”, and
“Premises”, respectively, shall be deemed to refer to “Landlord”, “Sublessee”, this “Sublease” and the “Subleased Premises”, respectively (i.e., it is the intention of the parties that
Landlord shall retain all of its rights and obligations under such sections and/or provisions; that Sublessor shall not be entitled to exercise any of Landlord’s rights, nor shall be bound by any of Landlord’s obligations, under such
sections and/or provisions; and that Sublessee shall be entitled to exercise all of Sublessor’s rights, and shall be bound by all of Sublessor’s obligations, under such sections and/or provisions): Section 2.3 (Landlord’s
Reservations); Section 4.3 (Construction Requirements for Alterations), except the term “Tenant’s Work” shall refer to work performed by Sublessee under this Sublease and the term “Initial Leasehold Improvements”
and the parenthetical “(except as otherwise provided in the Work Letter with respect to the Initial Leasehold Improvements)” are hereby specifically not incorporated in this Sublease; Section 5.1 (Maintenance of Building and
Common Areas by Landlord); Section 5.6 (Landlord’s Responsibilities regarding Hazardous Materials); Section 7.4 (Landlord’s Insurance); Section 10.1 (Subordination); and Section 12.10 (Ground
Lease), except the term “Tenant” as used in this section shall continue to refer to Sublessor and not Sublessee. 

  

 17 

	 	c.	The following provisions of the Prime Lease shall not be incorporated herein by reference and are expressly excluded from the terms of this Sublease:

 Section 2.1(b); Section 2.1(c); Section 2.5 (Prior Leases Superseded;
Commencement Date); Section 2.6 (Extension Options); Section 2.7 (Expansion Rights); Section 2.8 (Stub Period); Section 3.1 (Annual Fixed Rent); Section 3.2 (Real Estate Taxes) (except that
these provisions shall be included for the limited purpose of determining Sublessee’s Allocable Share of “Tenant’s Tax Expense Allocable to the Premises” as set forth in Section 4.b above); Section 3.3 (Operating
Expenses) (except that these provisions shall be included for the limited purpose of determining Sublessee’s Allocable Share of “Tenant’s Operating Expenses Allocable to the Premises” as set forth in Section 4.b above);
Section 3.5 (Above-standard Services); Section 5.2 (Maintenance of Premises by Tenant); Section 5.3 (Tenant-Provided Services); Section 6.8 (Assignment and Subleases); Section 7.1 (Indemnity);
Section 7.2 (Liability Insurance); Section 7.6 (Policy Requirements); Section 8.1 (Restoration Following Casualties); Section 8.2 (Landlord’s Termination Election); Section 8.3
(Tenant’s Termination Elections); Section 8.4 (Casualty at Expiration of Lease); Section 8.5 (Eminent Domain); Section 8.8 (Taking Award); Section 9.1 (Tenant’s Default); Section 9.2
(Damages); Section 9.3 (Cumulative Rights); Section 9.6 (Late Charges, Interest on Overdue Payments); Section 10.3 (Tenant’s Duty to Notify Mortgagee and Ground Lessor; Mortgagee’s and Ground
Lessor’s Ability to Cure); Section 12.2 (Notices); Section 12.4 (Waivers); Section 12.8 (Brokerage); and Section 12.11 (Financial Reporting); provided, however, that notwithstanding such
non-incorporation, this Sublease remains subject and subordinate to all of the foregoing provisions as provided in Section 14.a above. 
 [Remainder of page intentionally left blank] 
  

 18 

 IN WITNESS WHEREOF, Sublessor and Sublessee have duly executed this Sublease the day and
year first above written. 
  

			
	SUBLESSOR:
	
	ALKERMES, INC.
		
	By:	 	/s/ James Frates
	Name: 	 	James Frates
	Title:	 	CFO
	
	SUBLESSEE:
	
	AVEO PHARMACEUTICALS, INC.
		
	By:	 	/s/ David B. Johnston
	Name: 	 	David B. Johnston
	Title:	 	CFO

  

 19 

 EXHIBIT A 
 Prime Lease 
  

 20 

 FIRST AMENDMENT TO LEASE 
 THIS FIRST AMENDMENT TO LEASE (hereinafter referred to as the “Amendment”) is dated as of this — day of April, 2002, by and
between FOREST CITY 64 SIDNEY STREET, INC., a Massachusetts corporation (“Landlord”) and ALKERMES, INC., a Pennsylvania corporation (“Tenant”). Capitalized terms used herein and not otherwise defined shall have the meaning
ascribed to such term in the Lease (as hereinafter defined). 
 W I T N E S S E T H 
 WHEREAS, Landlord and Tenant entered into that certain Lease dated October 26, 2000, for premises in the building located at 64 Sidney
Street, Cambridge; and 
 WHEREAS, Landlord and Tenant desire to extend the Initial Term of the Lease with respect to Suite 300
and Suite 180; 
 WHEREAS, Landlord and Tenant desire to amend the Annual Fixed Rent for the Initial Term with respect to Suite
300 and Suite 180; and 
 WHEREAS, Landlord desire to provide Tenant with an improvement allowance for Suite 300 and Suite
180. 
 NOW, THEREFORE, in consideration of the premises and mutual covenants hereinafter contained and other valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
  

	 	1.	Effective as of the date hereof, Section 1.2 of the Lease shall be amended to include the following term and definition: 

 “Rental Changeover Date” means that date which is the earlier to occur of (i) thirty (30) days from date Tenant first
occupies space in the building located at 88 Sidney Street pursuant to the 88 Sidney Lease, or (ii) August 1, 2002. 
  

	 	2.	Effective as of the 88 Sidney Rent Commencement Date, Section 2.1(b) of the Lease shall be deleted in its entirety. 

  

	 	3.	Effective as of the 88 Sidney Rent Commencement Date, the third and fourth bullet points in the term “Annual Fixed Rent for the Initial Term” set forth on
Exhibit A to the Lease shall be deleted in their entirety and replaced with the following: 

  

	 	•	 	 With respect to the Rentable Floor Area of Suite 300: (i)         per rentable square foot for the period from
the Commencement Date until the Rental Changeover Date, (ii)         per rentable square foot for the period from the Rental Changeover Date until the fifth anniversary of the 88 Sidney Rent Commencement Date,
and (iii)         per rentable square foot for the period from the fifth anniversary of the 88 Sidney Rent Commencement Date for the remainder of the Initial Term. 

	 	•	 	 With respect to the Rentable Floor Area of Suite 180: (i)              per rentable
square foot for the period from the Commencement Date until the Rental Changeover Date, (ii)              per rentable square foot for the period from the Rental Changeover Date until
the fifth anniversary of the 88 Sidney Rent Commencement Date, and (iii)              per rentable square foot for the period from the fifth anniversary of the 88 Sidney Rent
Commencement Date for the remainder of the Initial Term. 

  

	 	4.	Landlord and Tenant hereby confirm and agree that the Leasehold Improvement Allowance shall apply to Suites 300 and 180. 

  

	 	5.	This Amendment may be executed in any number of counterparts, each of which shall be deemed an original and all of which together shall constitute one and the same
instrument. 

  

	 	6.	The Lease, as amended hereby, is in full force and effect, and is ratified and confirmed, and there are no other amendments or modifications thereto;

  

	 	7.	This Amendment will be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment under seal, as of the day, month and year first above written. 
  

			
	LANDLORD:
	
	FOREST CITY 64 SIDNEY STREET, INC., a Massachusetts corporation
		
	By:	 	/s/ Michael Farley
	Name: 	 	Michael Farley
	Title:	 	Vice President
	
	TENANT:
	
	ALKERMES, INC.,
	a Pennsylvania corporation
		
	By:	 	 /s/ James M. Frates 

	Name: 	 	James M. Frates
	Title:	 	Vice President

 LEASE 
 64 Sidney Street 
 Cambridge, Massachusetts 
 LANDLORD 
  
  
 FOREST CITY 64
SIDNEY STREET, INC. 
 TENANT 
  
  
 ALKERMES, INC.

 Dated: October 26, 2000 

 Table of Contents 
  

					
	 	  	 	  	Page
	 ARTICLE 1
	  		  	
	 RECITALS AND DEFINITIONS
	  	1
	 Section 1.1
	  	Recitals	  	1
	 Section 1.2
	  	Definitions	  	1
			
	 ARTICLE 2
	  		  	
	 PREMISES AND TERM
	  	4
	 Section 2.1
	  	Premises	  	4
	 Section 2.2
	  	Appurtenant Rights	  	5
	 Section 2.3
	  	Landlord’s Reservations	  	5
	 Section 2.4
	  	Parking Passes	  	6
	 Section 2.5
	  	Prior Leases Superseded; Commencement Date	  	6
	 Section 2.6
	  	Extension Options	  	7
	 Section 2.7
	  	Expansion Rights	  	9
	 Section 2.8
	  	Stub Period	  	11
		
	 ARTICLE 3
 RENT AND OTHER PAYMENTS
	  	11
	 Section 3.1
	  	Annual Fixed Rent	  	11
	 Section 3.2
	  	Real Estate Taxes	  	11
	 Section 3.3
	  	Operating Expenses	  	13
	 Section 3.4
	  	Utility Charges	  	17
	 Section 3.5
	  	Above-standard Services	  	17
	 Section 3.6
	  	No Offsets	  	17
		
	 ARTICLE 4
 ALTERATIONS
	  	18
	 Section 4.1
	  	Consent Required for Tenant’s Alterations	  	18
	 Section 4.2
	  	Ownership of Alterations	  	19
	 Section 4.3
	  	Construction Requirements for Alterations	  	20
	 Section 4.4
	  	Payment for Tenant Alterations	  	21
		
	 ARTICLE 5
 RESPONSIBILITY FOR CONDITION OF BUILDING AND PREMISES
	  	21
	 Section 5.1
	  	Maintenance of Building and Common Areas by Landlord	  	21
	 Section 5.2
	  	Maintenance of Premises by Tenant	  	21
	 Section 5.3
	  	Tenant-Provided Services	  	22
	 Section 5.4
	  	Delays in Landlord’s Services	  	22
	 Section 5.5
	  	Tenant’s Responsibilities Regarding Hazardous Materials	  	23
	 Section 5.6
	  	Landlord’s Responsibilities Regarding Hazardous Materials	  	24
	 Section 5.7
	  	Cross Indemnification	  	24

  

 (i) 

					
	 	  	 	  	Page
	 ARTICLE 6
 TENANT COVENANTS
	  	24
	 Section 6.1
	  	Permitted Uses	  	24
	 Section 6.2
	  	Laws and Regulations	  	25
	 Section 6.3
	  	Rules and Regulations; Signs	  	25
	 Section 6.4
	  	Safety Compliance	  	25
	 Section 6.5
	  	Landlord’s Entry	  	26
	 Section 6.6
	  	Floor Load	  	26
	 Section 6.7
	  	Personal Property Tax	  	26
	 Section 6.8
	  	Assignment and Subleases	  	26
		
	 ARTICLE 7
 INDEMNITY AND INSURANCE
	  	29
	 Section 7.1
	  	Indemnity	  	29
	 Section 7.2
	  	Liability Insurance	  	30
	 Section 7.3
	  	Personal Property at Risk	  	30
	 Section 7.4
	  	Landlord’s Insurance	  	31
	 Section 7.5
	  	Waiver of Subrogation	  	31
	 Section 7.6
	  	Policy Requirements	  	31
		
	 ARTICLE 8
 CASUALTY AND EMINENT DOMAIN
	  	32
	 Section 8.1
	  	Restoration Following Casualties	  	32
	 Section 8.2
	  	Landlord’s Termination Election	  	32
	 Section 8.3
	  	Tenant’s Termination Elections	  	32
	 Section 8.4
	  	Casualty at Expiration of Lease	  	33
	 Section 8.5
	  	Eminent Domain	  	33
	 Section 8.6
	  	Rent After Casualty or Taking	  	34
	 Section 8.7
	  	Temporary Taking	  	34
	 Section 8.8
	  	Taking Award	  	34
	 Section 8.9
	  	Casualty or Eminent Domain Affecting Parking Privileges	  	34
		
	 ARTICLE 9
 DEFAULT
	  	36
	 Section 9.1
	  	Tenant’s Default	  	36
	 Section 9.2
	  	Damages	  	37
	 Section 9.3
	  	Cumulative Rights	  	37
	 Section 9.4
	  	Landlord’s Self-help	  	38
	 Section 9.5
	  	Enforcement Expenses; Litigation	  	38
	 Section 9.6
	  	Late Charges; Interest on Overdue Payments	  	38
	 Section 9.7
	  	Landlord’s Right to Notice and Cure; Tenant’s Self-Help Rights	  	38
		
	 ARTICLE 10
 MORTGAGEES’ AND GROUND LESSORS’ RIGHTS
	  	39
	 Section 10.1
	  	Subordination	  	39

  

 (ii) 

					
	 	  	 	  	Page
	 Section 10.2
	  	Prepayment of Rent not to Bind Mortgagee or Ground Lessor	  	39
	 Section 10.3
	  	Tenant’s Duty to Notify Mortgagee and Ground Lessor; Mortgagee’s and Ground Lessor’s Ability to Cure	  	39
	 Section 10.4
	  	Estoppel Certificates	  	40
	 Section 10.5
	  	Subordination, Nondisturbance and Attornment Agreements	  	41
		
	 ARTICLE 11
 SECURITY DEPOSIT
	  	41
		
	 ARTICLE 12
 MISCELLANEOUS
	  	42
	 Section 12.1
	  	Notice of Lease	  	42
	 Section 12.2
	  	Notices	  	43
	 Section 12.3
	  	Successors and Limitation on Liability	  	43
	 Section 12.4
	  	Waivers	  	43
	 Section 12.5
	  	Acceptance of Partial Payments of Rent	  	43
	 Section 12.6
	  	Interpretation and Partial Invalidity	  	44
	 Section 12.7
	  	Quiet Enjoyment	  	44
	 Section 12.8
	  	Brokerage	  	44
	 Section 12.9
	  	Surrender of Premises and Holding Over	  	44
	 Section 12.10
	  	Ground Lease	  	45
	 Section 12.11
	  	Financial Reporting	  	45
	 Section 12.12
	  	Cambridge Employment Plan	  	45
	 Section 12.13
	  	Track Delivery Routes; Traffic Mitigation Measures	  	45
	 Section 12.14
	  	Parking and Transportation Demand Management	  	46
	 Section 12.15
	  	Laboratory Animals	  	46
	 Section 12.16
	  	No Consequential Damages	  	46
	 Section 12.17
	  	Governing Law	  	46

  

					
	 EXHIBIT A
	  	-	  	Basic Lease Terms
	 EXHIBIT B
	  	-	  	Legal Description
	 EXHIBIT B-l
	  	-	  	Depiction of Premises
	 EXHIBIT B-2
	  	-	  	Map of University Park
	 EXHIBIT C
	  	-	  	Work Letter
	 EXHIBIT D
	  	-	  	Standard Services
	 EXHIBIT E
	  	-	  	Rules and Regulations
	 EXHIBIT F
	  	-	  	Intentionally Omitted
	 EXHIBIT G
	  	-	  	Form of MIT Non-Disturbance Agreement
	 EXHIBIT H
	  	-	  	Intentionally Omitted
	 EXHIBIT I
	  	-	  	Expedited Dispute Resolution Procedure

  

 (iii) 

 LEASE 
 ARTICLE 1 
 RECITALS AND DEFINITIONS 
 Section 1.1 Recitals. This Lease (this “Lease”) is entered into this 26th day of October, 2000 by and between Forest
City 64 Sidney Street, Inc. (the “Landlord”), a Massachusetts corporation, and Alkermes, Inc. (the “Tenant”), a Pennsylvania corporation. 
 In consideration of the mutual covenants herein set forth, the Landlord and the Tenant do hereby agree to the terms and conditions set forth in this Lease. 
 Section 1.2 Definitions. The following terms shall have the meanings indicated or referred to below: 
 “Additional Rent” means all charges payable by the Tenant pursuant to this Lease other than Annual Fixed Rent, including without
implied limitation the Tenant’s parking charges as provided in Section 2.4; the Tenant’s Tax Expense Allocable to the Premises as provided in Section 3.2; the Tenant’s Operating Expenses Allocable to the Premises in
accordance with Section 3.3; amounts payable to Landlord for separately submetered utilities and services pursuant to Section 3.4; amounts payable for special services pursuant to Section 3.5; costs for alterations or additions to the
Premises exceeding the Tenant’s Allowance (as described in the Work Letter); and the Landlord’s share of any sublease or assignment proceeds pursuant to Section 6.8. 
 “Annual Fixed Rent” - See Exhibit A, and Section 3.1. 
 “Base Building Improvements” - See the Work Letter. 
 “Building” means the building located at 64 Sidney Street, Cambridge, Massachusetts. 
 “Commencement Date” - See Section 2.5. 
 “Common Areas” -
see Section 2.2. 
 “Declaration of Covenants” means that certain Declaration of Covenants dated as of
December 15, 1997 made by Massachusetts Institute of Technology, as declarant, recorded on March 12, 1998 in the Middlesex South Registry of Deeds as Instrument No. 1065 and filed on March 12, 1998 in the Middlesex South Registry
District of the Land Court as Document No. 1058425. 
 “Default Interest Rate” - see Section 9.6.

 “88 Sidney Lease” means that certain lease, dated as of even date herewith,
between the Landlord and the Tenant, of the building in University Park located at 88 Sidney Street, Cambridge, Massachusetts. 
 “88 Sidney Non-fruition Termination” - See Section 2.1 (c). 
 “88 Sidney Rent Commencement
Date” - See Section 2.1 (b). 
 “Expedited Dispute Resolution Procedure” means the dispute resolution
procedure described in Exhibit I. 
 “Extension Term” - See Section 2.6. 
 “Excusable Delay” - See the Work Letter. 
 “External Causes” means, when referring to a party’s responsibilities under this Lease, collectively Acts of God, war, civil commotion, fire, flood or other casualty, strikes or other
extraordinary labor difficulties or shortages of labor or materials or equipment in the ordinary course of trade, extraordinary weather conditions, government order or regulations or other cause not reasonably within the control of such party, and
not due to the fault or neglect of such party. In no event shall financial inability be deemed to be an External Cause. 
 “Garage” - See Exhibit A. 
 “Initial Leasehold Improvements” means the initial alterations
and additions which Tenant is undertaking pursuant to the Work Letter. 
 “Initial Term” - See Exhibit A.

 “Land” means the parcel of land situated in Cambridge, Massachusetts, described in Exhibit B. 
 “Landlord’s Original Address” - See Exhibit A. 
 “Lease Year” means each period of one year during the Term commencing on the Commencement Date or on any anniversary thereof.

 “Market Rate Parking Charge” means the monthly parking rate for structured parking facilities charged from time to
time by owners of parking facilities of similar age and quality, providing similar convenience and proximity to the work environment, and similar services and amenities, in the geographical area in which the Garage is located. As of the date hereof,
parking facilities most similar to the Garage are the parking facilities of Cambridge Center, Technology Square and One Kendall Square. 
 “Parking Passes” - See Exhibit A. 
  

 2 

 “Permitted Uses” - See Exhibit A. 
 “Premises” means 
 (i) the entire rentable area of the fourth (plus the acid neutralization room on the first floor) and fifth floors of the Building, consisting of 27,083 rentable square feet on the fourth floor (which
includes the aforesaid first floor space) and 26,148 rentable square feet on the fifth floor, for an aggregate rentable area of 53,231 rentable square feet; and 
 (ii) the rentable area of Suite 300 on the third floor of the Building, consisting of 4,335 rentable square feet, and the
rentable area of Suite 180 on the first floor, consisting of 7,407 rentable square feet, for an aggregate rentable area of 11,742 rentable square feet. 
 See Exhibit A and Sections 2.1 and 2.3. 
 “Property” means the
Land and the Building. 
 “Removable Alterations” - See Section 4.2. 
 “Rules and Regulations” - See Section 6.3. 
 “Stub Period” means the period, if any, from May 1, 2012 until the scheduled expiration date of the initial term of the 88 Sidney Lease. 
 “Substantial Completion” - See the Work Letter. 
 “Tenant’s Original Address” - See Exhibit A 
 “Term” means the Initial Term (plus any Stub Period added to the Initial Term under Section 2.8) together with any Extension Term for which an extension option is timely exercised by the Tenant under Section 2.6.

 “Termination Date” - See Exhibit A. 
 “University Park” means the area in Cambridge, Massachusetts, bounded on the North side by Massachusetts Avenue, Green and Blanche
Streets, on the East side by Landsdowne, Cross and Purrington Streets, on the South side by Pacific Street and on the West side by Brookline Street, as shown on Exhibit B-2. 
 “Work Letter” means the letter agreement of even date herewith between the Landlord and Tenant relating to the construction of the
leasehold improvements in the Premises attached hereto and made a part hereof as Exhibit C. The Work Letter is incorporated by reference and shall be deemed to be a part of this Lease. 
  

 3 

 ARTICLE 2 
 PREMISES AND TERM 
 Section 2.1 Premises.

 (a) The Landlord hereby leases to the Tenant, and the Tenant hereby leases from the Landlord, for the Term,
the Premises, which shall be comprised of the space illustrated on Exhibit B-1, subject to the exclusion hereinbelow set forth in this Section 2.1, Landlord’s reservations set forth in Section 2.3, such easements, covenants and
restrictions as may affect the Property and the terms and conditions of this Lease. The Tenant acknowledges that, except as expressly set forth in this Lease, there have been no representations or warranties made by or on behalf of the Landlord with
respect to the Premises, the Building or the Property or with respect to the suitability of any of them for the conduct of the Tenant’s business. The Premises shall exclude the entry and main lobby of the Building, first floor elevator lobby,
first floor mail room, the common stairways and stairwells, elevators and elevator wells, boiler room, sprinklers, sprinkler rooms, elevator rooms, mechanical rooms, loading and receiving areas, electric and telephone closets, janitor closets, and
pipes, ducts, conduits, wires and appurtenant fixtures and equipment serving exclusively or in common other parts of the Building. If the Premises at any time includes less than the entire rentable floor area of any floor of the Building, the
Premises shall also exclude the common corridors, vestibules, elevator lobby, toilets, janitor’s closet, electrical and telephone closet, and freight elevator vestibule located on such floor. 
 (b) The Tenant shall, on the thirtieth (30th) day following the occurrence of the “Rent Commencement Date”
under the 88 Sidney Lease (the “88 Sidney Rent Commencement Date”), surrender a portion of the Premises comprised of Suites 300 and 180 (the “Surrender Space”) upon the terms and conditions of Section 12.9 hereof, and
thereupon the Surrender Space shall be deleted from the Premises demised hereunder except and to the extent thereafter reincorporated into the Premises in accordance with Section 2.7 hereof. In the event of an 88 Sidney Non-fruition
Termination, the Tenant may not, and shall not, surrender the Surrender Space until the expiration or earlier termination of this Lease, except as otherwise expressly provided in Section 2.1 (c) below. 
 (c) Notwithstanding anything to the contrary set forth in this Lease, if the 88 Sidney Lease should be terminated, whether by
the Landlord or the Tenant, pursuant to either Section 2.7 of said 88 Sidney Lease or Article 16 of Exhibit C thereto (“88 Sidney Non-fruition Termination”), then the Tenant shall have the option, exercisable by notice
(“Expiration Acceleration Notice”) given to the Landlord within one hundred eighty (180) days of the date of the 88 Sidney Non-fruition Termination, to either (i) accelerate the Termination Date of this Lease with respect to the
entire Premises, to the date specified in such Expiration Acceleration Notice, which may not be sooner than twelve (12) months nor later than fifteen (15) months following the date Expiration Acceleration Notice is so given or
(ii) accelerate the Termination Date of this Lease only with respect to (x) Suite 300 and 180 only, (y) Suite 300 only or (z) Suite 180 only, in which case the portion of the Premises so identified will be deleted from the
Premises on the date specified in such Expiration Acceleration Notice, which may not be sooner than twelve (12) months nor later than fifteen (15) months following the date the Expiration Acceleration Notice is so given. The Tenant’s
failure to accelerate the Termination Date of this Lease with respect to the entire Premises or just the portions thereof

  

 4 

 
hereinabove described, by the giving of Expiration Acceleration Notice in accordance with this Section 2. 1(c), during the aforesaid one hundred eighty (180) day period, time being of
the essence without limitation of anything otherwise set forth in this Lease, shall result in the waiver of the Tenant’s right to so accelerate the Termination Date, and this Lease shall remain in effect with respect to the entire Premises
(including without limitation any portion of the Surrender Space not specified in the Expiration Acceleration Notice) subject to the terms and conditions of this Lease without giving effect to Section 2.1 (b) and (c) hereof.

 Section 2.2 Appurtenant Rights. 
 (a) The Tenant shall have, as appurtenant to the Premises, the nonexclusive right to use in common with others, subject to
the Rules and Regulations, (i) the entry, vestibules and main lobby of the Building, first floor mail room, the common stairways, elevators, elevator wells, boiler room, elevator rooms, sprinkler rooms, mechanical rooms, the pipes, sprinklers,
ducts, conduits, wires and appurtenant fixtures and equipment serving the Premises in common with others, (ii) common walkways and driveways situated upon the land that are necessary or reasonably convenient for access to the Building, and all
other areas in and amenities of University Park as are made available generally to the occupants of University Park or the general public, (iii) access to, and use of in common with other tenants, loading area and freight elevator,
janitor’s closet, and electrical and telephone closets, portions of the rooftop Penthouse reserved for Tenant use, provided Tenant has equipment located therein, subject to Rules and Regulations, as hereinafter defined in Exhibit E, then in
effect and (iv) if the Premises at any time include less than the entire rentable floor area of any floor, the common toilets, corridors, vestibules, bridges and appurtenant right to the Premises the right to use portions of the roof of the
Building, outside of the Base Building Penthouse on the roof, as shall be reasonably designed by Landlord for location of Tenant equipment. All Tenant’s installations of equipment on the roof and any required interior and/or exterior ducts
shall be subject to Landlord’s reasonable approval, and in no event shall such installation exceed the live load, or the Base Building System capacity as allocated to Tenant or University Park design guidelines all as approved by Landlord and
permitted under the appropriate building code such approval not to be unreasonably withheld or delayed (collectively, the “Common Areas”). 
 (b) The Tenant shall have, as appurtenant to the Premises, the right to enjoy such easements of ingress and egress over other land within University Park as may benefit the Property as more particularly
contemplated under the Declaration of Covenants. 
 (c) The Tenant shall have, as appurtenant to the Premises,
the parking rights set forth in Section 2.4. 
 Section 2.3 Landlord’s Reservations. The Landlord reserves
the right from time to time, without unreasonable interference with the Tenant’s use to alter or modify the Common Areas, provided that (i) the Landlord gives the Tenant reasonable advance notice of the Landlord’s contemplated
alterations or modifications, with respect to which the Tenant shall have reasonable approvals rights, (ii) any such actions are effected in a good and workmanlike manner at no additional cost to Tenant (other than improvements thereto the
costs of which are shared by tenants in University Park pursuant to the Declaration of Covenants), and (iii) such alterations or modifications do not impair Tenant’s access to the Premises or its practical use and enjoyment thereof or of
the Common Areas. 
  

 5 

 Section 2.4 Parking Passes. The Landlord shall provide and the Tenant shall pay
for Parking Passes (as defined, in Exhibit A) for use by the Tenant’s employees in accordance with Exhibit A. Charges for the Tenant’s parking privileges hereunder shall be determined in accordance with Exhibit A,
shall constitute Additional Rent and shall be payable monthly to the Landlord, during the Term, from and after the Rent Commencement Date. The Tenant agrees that it and all persons claiming by, through and under it, shall at all times abide by the
Rules and Regulations set forth on Exhibit E and any other rules and regulations promulgated by the Landlord in accordance with Section 6.3, of which the Tenant is given written notice, with respect to the use of the parking facilities
provided by the Landlord pursuant to this Lease. The Landlord acknowledges that it is the Landlord’s responsibility to assure that holders of Parking Passes who fulfill the requirements of the Rules and Regulations are able to park their motor
vehicles in the designated parking facilities. 
 At the option of the Landlord, the Tenant shall enter into a separate
agreement, with the Landlord or a separate entity, or the Landlord may assign the Landlord’s rights and obligations with respect to such parking privileges to a separate entity, upon the same terms and conditions contained in this Lease (and
cross-defaulted, both as to the Landlord’s and Tenant’s obligations, with this Lease) for a period which shall have the same expiration date as the Term and which, if this Lease provides for options on the part of the Tenant to extend,
shall be automatically extended upon the exercise of any of such options. 
 Section 2.5 Prior Leases Superseded;
Commencement Date. The Tenant is currently occupying the Premises pursuant to that certain lease, dated September 18, 1991, as amended by that certain First Amendment of Lease, dated September 1, 1992 and that certain Second Amendment
to Lease, dated December 20, 1993 (collectively referred to as the “Original 64 Sidney Lease”) and pursuant to that certain lease dated March 16, 1990, by and between Forest City 64 Sidney Street, Inc., as Landlord, and Enzytech,
Inc., as Tenant, as amended by those certain letter agreements dated March 11, 1999, April 13, 1999 and May 28, 1999, respectively, between the Landlord and the Tenant, as successor to Enzytech (collectively, the “Former
Enzytech Lease”), each of which is terminated and superseded by this Lease. The Tenant acknowledges that, except to the extent already paid, any amounts now due to the Landlord under the aforesaid leases shall be immediately due and payable
under this Lease and are not affected by the termination of the aforesaid leases. In respect of the fifth floor of the Building, which has been occupied by the Tenant since August 15, 2000 without a definitive rental rate with respect thereto
having been established, the Tenant shall pay the Landlord Annual Basic Rent with respect thereto for the period from August 15, 2000 through the Commencement Date hereof (less any amounts heretofore paid by the Tenant on account of basic rent
thereunder allocable to such period) at the rate of Thirty Seven and 50/100 Dollars ($37.50) per rentable square foot of the fifth floor of the Building, and shall be liable to the Landlord with respect to such space hereunder. The
“Commencement Date” of this Lease means the date hereof. 
  

 6 

 Section 2.6 Extension Options. Provided that there has been no Event of Default
which is uncured and continuing on the part of the Tenant, and the Tenant is, as of the date of exercise and as of the commencement date of each Extension Term, actually occupying at least fifty percent (50%) of the Premises for its own
business purposes, the Tenant shall have the right to extend the Term hereof for two (2) successive periods of ten (10) years each (each such period an “Extension Term”) on the following terms and conditions: 
 (a) Such right to extend the Term shall be exercised by the giving of notice by Tenant to Landlord at least twelve
(12) months prior to the expiration of the Initial Term or the then current Extension Term, as applicable (the “Extension Notice Deadline Date”). Upon the giving of such notice on or before the Extension Notice Deadline Date, this
Lease and the Term hereof shall be extended for an additional term, as specified above, without the necessity for the execution of any additional documents except a document memorializing the Annual Fixed Rent for the Extension Term to be determined
as set forth below. Time shall be of the essence with respect to the Tenant’s giving notice to extend the Term on or before the Extension Notice Deadline Date. In no event may the Tenant extend the Term under this Section 2.6 for more than
twenty (20) years after the expiration of the Initial Term. 
 (b) Each Extension Term shall be upon all the
terms, conditions and provisions of this Lease, except the Annual Fixed Rent payable during each Extension Term shall be the then Extension Fair Rental Value of the Premises for such Extension Term, to be determined under Section 2.6(d) or
Section 2.6(e) below, but in no case less than the Annual Fixed Rent that was applicable thereto immediately preceding the Extension Term with respect to which the Extension Fair Rental Value is to be established (the “Then Applicable
Annual Fixed Rental Rate”). For purposes of this Section 2.6, the “Extension Fair Rental Value” of the Premises shall mean the then current fair market annual rent, for leases of other space in Cambridge, Massachusetts similarly
improved, taking into account the condition to which such premises have been improved (including any replacements of existing improvements or performance of maintenance obligations (“Replacements”), but excluding any capital improvements
to the Premises (i.e., other than Replacements) that enhance the value thereof, provided the same are made by the Tenant during the sixty (60) month period immediately preceding the applicable Extension Notice Deadline Date), and the economic
terms and conditions specified in this Lease that will be applicable thereto. 
 (c) If the Tenant makes a
written request to the Landlord for a proposal for the Extension Fair Rental Value for the upcoming Extension Term (“Tenant’s Extension Rental Request”) on or before the day two (2) months prior to the Extension Notice Deadline
Date, then the Landlord shall make such a written proposal (“Landlord’s Proposal”) to the Tenant within fifteen (15) days after receipt of Tenant’s Extension Rental Request, but in no event shall the Landlord be required to
deliver such a proposal sooner than fifteen (15) months prior to the scheduled commencement of such Extension Term. Following delivery by the Landlord of Landlord’s Proposal to the Tenant, the parties will endeavor in good faith to reach
agreement with respect to the establishment of the Extension Fair Rental Value for the Extension Term. 
  

 7 

 (d) Unless the parties have already mutually agreed upon such Extension Fair
Rental Value, on or before the day that is ten (10) days prior to the applicable Extension Notice Deadline Date, the Landlord and the Tenant shall deliver to each other their final Landlord’s Proposal (or any final change that the Landlord
wishes to make to any previously furnished Landlord’s Proposal) and a written proposal from the Tenant for the Extension Fair Rental Value of the Premises (the “Tenant’s Proposal”), as the case may be, and each of such
Landlord’s Proposal and such Tenant’s Proposal shall be binding on the Landlord and the Tenant, respectively, for the purpose of conducting the resolution procedure described in clause (e) below. Failure by the Landlord or the Tenant
to timely deliver a final Landlord’s Proposal or final Tenant’s Proposal (time being of the essence), as the case may be, shall result in the other party’s proposal being deemed the Extension Fair Rental Value, and failure by the
Landlord or the Tenant to timely make any final change to the then most recently delivered Landlord’s Proposal or Tenant’s Proposal, as the case may be, shall render no longer subject to change the last previously delivered Landlord’s
Proposal or Tenant’s Proposal, as the case may be, which shall thereupon become final. 
 (e) If the Tenant
exercises its election to extend the Term under clause (a) above, without the Extension Fair Rental Value of the Premises having been established by mutual agreement of the parties as contemplated under clause (c) above, then unless a
final Landlord’s Proposal and a final Tenant’s Proposal has been established under clause (d) above, the Landlord shall furnish a final Landlord’s Proposal to the Tenant, and the Tenant shall furnish a final Tenant’s
Proposal to the Landlord, within thirty (30) days of the Tenant’s having exercised its election to extend the Term. Within thirty (30) days after the later to occur of (x) the Tenant’s exercise of its election to extend the
Term or (y) the establishment of a final Landlord’s Proposal and a final Tenant’s Proposal in accordance with this clause (e), unless the parties have mutually agreed upon the identity of a real estate professional
(“Arbiter”) with at least ten (10) years continuous experience in the business of appraising or marketing similar commercial real estate in the Cambridge, Massachusetts area who has agreed to serve as hereinafter provided (the
“Deciding Arbiter”), the Landlord and the Tenant shall each appoint an Arbiter who shall, within thirty (30) days of selection, select a third Arbiter to serve as the Deciding Arbiter. The Deciding Arbiter shall select either
Landlord’s Proposal or Tenant’s Proposal as the proposal most accurately stating the Extension Fair Rental Value of the Premises. If the two Arbiters respectively selected by the parties (the “Party Selected Arbiters”) cannot
agree upon the selection of a Deciding Arbiter, then such two Party Selected Arbiters shall seek the selection of the Deciding Arbiter by the Greater Boston Real Estate Board. The Deciding Arbiter shall give notice of his or her selection to the
Landlord and the Tenant and its selection of either Landlord’s Proposal or Tenant’s Proposal shall be final and binding upon the Landlord and the Tenant. Each party shall pay the fees and expenses of its real estate professional counsel
and any Party Selected Arbiter that such party selects, if any, in connection with any proceeding under this paragraph, and one-half of the fees and expenses of the Deciding Arbiter. In the event that the commencement of the Extension Term occurs
prior to a final determination of the Extension Fair Rental Value therefor (the “Extension Rent Determination Date”), then the Tenant shall pay the Annual Fixed Rent in effect immediately preceding the commencement of

  

 8 

 
such Extension Term. If the Annual Fixed Rent for the Extension Term is determined to be greater than the Annual Fixed Rent paid with respect to the Premises prior to the Extension Rent
Determination Date, then the Tenant shall pay to the Landlord the amount of such underpayment within thirty (30) days of the Expansion Rent Determination Date. 
 Section 2.7 Expansion Rights. Provided that there has been no Event of Default which is uncured and continuing on the part of the Tenant, other than any which have been waived by the Landlord
and the Tenant, as of the date of exercise of its rights under this Section 2.7, and the Tenant is in occupancy of at least sixty percent (60%) of the Premises for its own business purposes, the Tenant shall have the Right of First
Opportunity (as hereinafter defined) to lease the following spaces: (A) approximately 50,000 rentable square feet on floors one, two and three (“Expansion Area 1”) as shown on Exhibit B-1 as Suites 330, 200 and 150;
(B) approximately 5,388 rentable square feet on the first floor (“Expansion Area 2”) as shown on Exhibit B-1 as Suite 100; and (C) approximately 7,407 rentable square feet on the first floor (“Expansion Area 3”)
as shown on Exhibit B-1 as Suite 180. Notwithstanding the foregoing, if at any time during the Term of this Lease, the Tenant shall lease Expansion Area 1 in accordance with this Section 2.7, the Tenant shall thereafter have the Right of
First Opportunity to lease any tenantable space in the Building which thereafter may become available, subject to the other terms and conditions of this Section 2.7. 
 With respect to each of Expansion Area 1, Expansion Area 2 and Expansion Area 3, following the expiration or earlier termination of the term of the lease for such space in effect as of the date of this
Lease (“Existing Third Party Lease”), as the term of such Third Party Lease may have been or hereafter is extended, Tenant shall have the Right of First Opportunity to lease the pertinent space as set forth below. Notwithstanding the
foregoing, the “Existing Third Party Lease” for Expansion Area 3 shall be the new lease entered into by Landlord with a tenant thereof after Tenant has vacated such space as contemplated by Section 2.1(b). If Tenant shall fail to
timely exercise its rights and thereafter lease any space in the Building to which it has the Right of First Opportunity, then the lease or leases thereafter entered into by the Landlord for such spaces shall be deemed the Existing Third Party Lease
with respect thereto. 
 For purposes of this Section 2.7, the “Right of First Opportunity” shall mean the
Tenant’s right, subordinate to the Landlord’s right to negotiate with the then existing tenant or other occupant of the space in question and permit such tenant or occupant to continue in occupancy (notwithstanding that such tenant or
occupant may not have the right to extend the term of the applicable Existing Third Party Lease for such space), to negotiate with Landlord to lease the space in accordance with this Section 2.7. From time to time during the Term of this Lease,
the Landlord shall give written notice to the Tenant (“Landlord’s First Opportunity Notice”) describing such space, the date of its expected availability and the terms and conditions on which the Landlord is interested in leasing such
space, taking into account the then current market conditions. The Tenant shall accept or decline Landlord’s First Opportunity Notice in writing, on or before the date which is ten (10) business days after the date of Landlord’s First
Opportunity Notice. If the Tenant fails to respond within such time period, or if the Tenant declines the Landlord’s offer, the Landlord shall thereafter be free to lease such space to any party on such terms as the Landlord shall choose in the
Landlord’s discretion, and the Tenant shall have no further rights to lease such space hereunder until the space thereafter becomes available following its leasing by

  

 9 

 
the Landlord, any such lease becoming the Existing Third Party Lease with respect thereto. If the Tenant shall accept Landlord’s First Opportunity Notice, or if the Tenant shall make a
counterproposal within the foregoing ten (10) business day tune period, the Landlord agrees to negotiate in good faith with the Tenant with respect to leasing of such space by the Tenant during the period ending fifteen (15) days after the
giving of such notice by the Tenant. If the parties cannot agree on the Annual Fixed Rent or any other material economic terms associated with a lease of such space within such 15 day period, but prior to the expiration of such 15-day period the
Tenant gives the Landlord notice that the Tenant commits to lease the space in question (the “Expansion Space”), upon all of the terms and conditions of the Landlord’s last offer but for the calculation of Annual Fixed Rent, then the
Annual Fixed Rent for such Expansion Space shall be determined in accordance with Section 2.6 above, except that the Annual Fixed Rent shall equal the “Expansion Fair Rental Value” as defined hereinbelow, and the Tenant shall be bound
to lease such space on the terms and conditions established under this Section 2.7. 
 For purposes of this
Section 2.7, the “Expansion Fair Rental Value” of Expansion Space shall mean the then current fair market annual rent for leases of space improved to the same level as the Premises and taking into account the condition to which such
premises have been improved (excluding Removable Alterations) and the economic terms and conditions specified in this Lease that will be applicable thereto (e.g. the amount of the fit-up allowance and the absence of any rent-free period for
construction of leasehold improvements), determined as provided below in this Section 2.7. If the Expansion Fair Rental Value of such Expansion Space is not agreed upon by the Landlord and the Tenant within the 15-day period referred to in the
grammatical paragraph immediately above (the “Rental Determination Commencement Date”), then each of the Landlord and the Tenant shall retain a real estate professional with at least ten (10) years continuous experience in the
business of appraising or marketing similar commercial real estate in the Cambridge, Massachusetts area who shall, within thirty (30) days of his or her selection, prepare a written report summarizing his or her conclusion as to the Expansion
Fair Rental Value. The Landlord and the Tenant shall simultaneously exchange such reports; provided, however, if either party has not obtained such a report within ninety (90) days after the Rental Determination Commencement Date, then the
determination set forth in the other party’s report shall be final and binding upon the parties. If both parties receive reports within such time and the lower determination is within ten percent (10%) of the higher determination, then the
average of these determinations shall be deemed to be the Expansion Fair Rental Value for such Expansion Space. If these determinations differ by more than ten percent (10%), then the Landlord and the Tenant shall mutually select a person with the
qualifications stated above (the “Final Professional”) to resolve the dispute as to the Expansion Fair Rental Value for such Expansion Space. If the Landlord and the Tenant cannot agree upon the designation of the Final Professional within
thirty (30) days of the exchange of the first valuation reports, either party may apply to the American Arbitration Association, the Greater Boston Real Estate Board, or any successor thereto, for the designation of a Final Professional. Within
ten (10) days of the selection of the Final Professional, the Landlord and the Tenant shall each submit to the Final Professional a copy of their respective real estate professional’s determination of the Expansion Fair Rental Value for
such Space. The Final Professional shall not perform his or her own valuation, but rather shall, within thirty (30) days after such submissions, select the submission which is closest to the

  

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determination of the Expansion Fair Rental Value for such Expansion Space which the Final Professional would have made acting alone. The Final Professional shall give notice of his or her
selection to the Landlord and the Tenant and such decision shall be final and binding upon the Landlord and the Tenant. Each party shall pay the fees and expenses of its real estate professional and counsel, if any, in connection with any proceeding
under this paragraph, and one-half of the fees and expenses of the Final Professional. In the event that the Tenant commences occupancy of any Expansion Space prior to a final determination of the Expansion Fair Rental Value therefor (the
“Expansion Rent Determination Date”), then the Tenant shall pay the Annual Fixed Rent at the rate specified in the Landlord’s written report of the Expansion Fair Rental Value until the Expansion Fair Rental Value is established. If
the Expansion Fair Rental Value is determined to be greater than the Annual Fixed Rent paid with respect to the Expansion Space prior to the Expansion Rent Determination Date, then the Tenant shall pay to the Landlord the amount of such underpayment
within ten (10) days of the Expansion Rent Determination Date, and if the Expansion Fair Rental Value is determined to be less than the Annual Fixed Rent paid with respect to the Expansion Space prior to the Expansion Rent Determination Date,
then the Landlord shall credit the amount of such overpayment against the monthly installments of Annual Fixed Rent thereafter coming due. 
 Section 2.8 Stub Period. The Landlord agrees that, if the scheduled expiration date of the initial term of the 88 Sidney Lease should, pursuant to the terms and conditions thereof, be
established as a date later than April 30, 2012, the Landlord shall, upon the Tenant’s request, agree to the extension of the Initial Term to include the Stub Period, and a confirmatory amendment to this Lease shall be entered into by the
parties to memorialize the same at the time the parties confirm the commencement and expiration dates of the 88 Sidney Lease. 
 ARTICLE 3 
 RENT AND OTHER PAYMENTS 
 Section 3.1 Annual Fixed Rent. From and after the Commencement Date, the Tenant shall pay, without notice or demand, monthly
installments of one-twelfth (1/12) of the Annual Fixed Rent in effect and applicable to the Premises in advance for each full calendar month of the Term following the Commencement Date and of the corresponding fraction of said one-twelfth
(1/12) for any fraction of a calendar month at the Commencement Date. The Annual Fixed Rent applicable to the Premises during the Initial Term shall be as set forth in Exhibit A. 
 Section 3.2 Real Estate Taxes. From and after the Commencement Date, during the Term, the Tenant shall pay to the Landlord, as
Additional Rent, the Tenant’s Tax Expenses Allocable to the Premises (as such term is hereinafter defined) in accordance with this Section 3.2. The terms used in this Section 3.2 are defined as follows: 
 (a) “Tax Fiscal Year” means the 12-month period beginning July 1 each year, or such other fiscal period in
respect of which real estate taxes are due and payable to the appropriate governmental taxing authority. 
  

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 (b) “The Tenant’s Tax Expense Allocable to the Premises”
means (i) that portion of the Landlord’s Tax Expenses for a Tax Year which bears the same proportion thereto as the Rentable Floor Area of the Premises (from time to time) bears to the Total Rentable Floor Area of the Building and
(ii) in the event that the Premises are improved to a standard which is higher than other portions of the Property, such portion of the Real Estate Taxes on the Property with respect to any Tax Year as is appropriate so that the Tenant bears
the portion of the Real Estate Taxes which are properly allocable to the Premises, as reasonably determined by Landlord based on information with respect to the assessment process made available by the assessing authorities. 
 (c) “The Landlord’s Tax Expenses” with respect to any Tax Fiscal Year means the aggregate Real Estate Taxes on
the Property with respect to that Tax Fiscal Year, reduced by any abatement receipts with respect to that Tax Fiscal Year. 
 (d) “Real Estate Taxes” means (i) all taxes and special assessments of every kind and nature assessed by any governmental authority on the Property; (ii) reasonable expenses incurred
in connection with negotiating with the city assessor’s office, in advance of the establishment of the assessed valuation of the Property, to establish a mutually agreeable assessment therefor; and (iii) reasonable expenses incurred in
connection with any proceedings for abatement of such taxes or special assessments. Any special assessments to be included within the definition of “Real Estate Taxes” shall be limited to the amount of the installment (plus any interest
thereon) of such special tax or special assessment (which shall be payable over the longest period permitted by law) required to be paid during the Tax Fiscal Year in respect of which such taxes are being determined. There shall be excluded from
such taxes all income, estate, succession, inheritance, excess profit, franchise and transfer taxes, all so-called linkage payments and delinquency interest or penalties; provided, however, that if at any time during the Term the present system of
ad valorem taxation of real property shall be changed so that in lieu of the whole or any part of the ad valorem tax on real property, there shall be assessed on the Landlord a capital levy or other tax on the gross rents received with
respect to the Property, or a federal, state, county, municipal or other local income, franchise, excise or similar tax, assessment, levy or charge (distinct from any now in effect) based, in whole or in part, upon any such gross rents, then any and
all of such taxes, assessments, levies or charges, to the extent so based, shall be deemed to be included within the term “Real Estate Taxes,” based on the Building being the Landlord’s only property. Landlord hereby agrees that it
will cause the Land to constitute a separate parcel with respect to the assessment of Real Estate Taxes. 
 Payments by the
Tenant on account of the Tenant’s Tax Expense Allocable to the Premises shall be made monthly at the time and in the fashion herein provided for the payment of Annual Fixed Rent and shall be in an amount of the greater of (i) one-twelfth
(1/12) of the Tenant’s Tax Expense Allocable to the Premises for the current Tax Fiscal Year as reasonably estimated by the Landlord, or (ii) an amount reasonably estimated by any ground lessor of the Land or holder of a first
mortgage on the Property, to be sufficient, if paid monthly, to pay the Tenant’s Tax Expense Allocable to the Premises on the dates due to the taxing authority. 
  

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 Not later than one hundred twenty (120) days after the Tenant’s Tax Expense
Allocable to the Premises are determinable for the first Tax Fiscal Year of the Term or fraction thereof and for each succeeding Tax Fiscal Year or fraction thereof during the Term, the Landlord shall render the Tenant a statement in reasonable
detail showing for the preceding year or fraction thereof, as the case may be, real estate taxes on the Property, and any abatements or refunds of such taxes, together with a copy of the tax bill for the Tax Fiscal Year in question. Reasonable
expenses incurred in obtaining any tax abatement or refund not previously charged may be charged against such tax abatement or refund before the adjustments are made for the Tax Fiscal Year. If at the time such statement is rendered it is determined
with respect to any Tax Fiscal Year, that the Tenant has paid (i) less than the Tenant’s Tax Expense Allocable to the Premises or (ii) more than the Tenant’s Tax Expense Allocable to the Premises, then, in the case of
(i) the Tenant shall pay to the Landlord, as Additional Rent, within thirty (30) days of such statement the amount of such underpayment and, in the case of (ii) the Landlord shall credit the amount of such overpayment against the
monthly installments of the Tenant’s Tax Expense Allocable to the Premises next thereafter coming due (or refund such overpayment within thirty (30) days if the Term has expired to the extent that such overpayment exceeds any amount then
due from the Tenant to the Landlord). To the extent that real estate taxes shall be payable to the taxing authority in installments with respect to periods less than a Tax Fiscal Year, the statement to be furnished by the Landlord shall be rendered
and payments made on account of such installments. If the Commencement Date occurs on other than the first day of a Tax Fiscal Year, or if the Termination Date occurs on other than the last day of a Tax Fiscal Year, then the amount of Tenant’s
Tax Expense Allocable to the Premises payable by the Tenant with respect to such Tax Fiscal Year(s) shall be pro-rated based upon the ratio of the length of the time period during such Tax Fiscal Year(s) in respect of which the Tenant has an
obligation to pay Tenant’s Tax Expense Allocable to the Premises to the length of such Tax Fiscal Year(s). 
 At the
reasonable request of the Tenant, the Landlord shall use reasonable efforts to contest or seek abatement of any Real Estate Taxes affecting the Premises. Should the Landlord contest or seek abatement of such taxes, then it shall do so with diligence
and shall keep the Tenant appropriately informed, in the Landlord’s reasonable discretion, as to such action. If there shall be any dispute between the Landlord and the Tenant regarding whether or not the Landlord is being reasonable in
electing not to contest or seek abatement of any Real Estate Taxes that the Tenant desires be contested or with respect to which the Tenant desires to seek abatement, such dispute shall, at the election of either the Landlord or the Tenant, be
resolved by the Expedited Dispute Resolution Procedure. 
 Section 3.3 Operating Expenses. From and after the
Commencement Date, during the Term, the Tenant shall pay to the Landlord, as Additional Rent, the Tenant’s Operating Expenses Allocable to the Premises, in accordance with this Section 3.3 including, without limitation, the conditions and
limitations set forth in clauses (a) through (k) below, with respect to each 12-month period beginning February 1 each year or such other fiscal period of twelve (12) consecutive months hereinafter adopted by the Landlord for
lease administration purposes (“Operating Fiscal Year”). “The Tenant’s Operating Expenses Allocable to the Premises” means that portion of the Operating Expenses for the Property which bears the same proportion thereto as
the Rentable Floor Area of the Premises bears to the Total Rentable Floor Area of the Building. The term “Operating Expenses for the Property” means the

  

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Landlord’s actual cost of operating, cleaning, maintaining and repairing the Property, the roads, driveways and walkways for providing access to the Building, and shall include without
limitation, the cost of fulfilling the maintenance and repair obligations required to be performed by Landlord under Section 5.1 and, subject to the exclusions set forth below, the cost of services specified on Exhibit D; premiums for
insurance carried pursuant to Section 7.4; the amount of any deductible associated with an insurance claim of the Landlord; compensation including, without limitation, fringe benefits, worker’s compensation insurance premiums and payroll
taxes paid to, for or with respect to all persons (University Park/Building general manager and below) engaged in the operating, maintaining or cleaning of the Property; interior landscaping and maintenance; steam, water, sewer, gas, oil
electricity, telephone and other utility charges (excluding any such utility charges either separately metered or separately chargeable to the Tenant for either measured or additional or special services); cost of providing HVAC services other than
such services described in Section 3.4; cost of building and cleaning supplies; the costs of routine environmental management programs operated by Landlord; market rental costs (or alternatively the Amortization Charge-off [as hereinafter
defined] so long as the expenses which are the subject of such Amortization Charge-off would have been permitted Operating Expenses had the item in question been purchased) with respect to equipment used in the operating, cleaning, maintaining or
repairing of the Property; cost of cleaning; cost of maintenance, and non-capital repairs and replacements; cost of snow removal; cost of landscape maintenance; security services; payments under service contracts with independent contractors;
management fees at reasonable rates consistent with comparable single-tenant or multi-tenant buildings, as applicable, in the Cambridge market with the type of occupancy and services rendered (the parties agree that for the first Lease Year, this
shall equal $0.85 per rentable square foot, and shall be subject to reasonable adjustments during subsequent Lease Years); the cost of any capital repairs, replacements or improvements: (i) required by any law or regulation enacted or
promulgated after the issuance of a building permit for the construction of the Building, (ii) which is required in order to maintain the Property in the condition it is required to be kept and maintained under Section 5.1,
(iii) which reduces the Operating Expenses for the Property, or (iv) which improves the management and operation of the Property in a manner reasonably acceptable to Tenant (all such capital costs to be amortized on a straight-line basis
in accordance with generally accepted accounting principles, together with interest on the unamortized balance at such rate as may have been paid by the Landlord on funds borrowed for the purpose of making such capital repairs, replacements or
improvements (or if the Landlord did not borrow such funds, then at the base lending rate announced by a major commercial bank designated by the Landlord), with only the annual amortization amount (“Amortization Charge-off”) being included
in Operating Expenses with respect to any Operating Fiscal Year); charges equitably and reasonably allocated to the Building for the operating, cleaning, maintaining, securing and repairing of the Common Areas excluding the initial capital
improvement costs associated with initially establishing the Common Areas; and all other reasonable and necessary (in the Landlord’s reasonable judgment) expenses paid in connection with the operation, cleaning, maintenance and repair of the
Property. 
  

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 Operating Expenses for the Property shall not include the following: 
  

	(a)	any cost or expense to the extent to which Landlord is paid or reimbursed, or which is reimbursable to the Landlord, from the Tenant or a third party (other than as a
payment for Operating Expenses), including but not necessarily limited to: (1) work or service performed for Tenant at its cost and (2) the cost of any item for which the Landlord is paid or reimbursed, or which is reimbursable, by
insurance, warranties, service contracts, condemnation proceeds, insurance reimbursements or otherwise; 

  

	(b)	salaries and bonuses of officers or executives of Landlord or administrative employees above the grade of University Park/Building general manager, and if personnel
below such grades are shared with other buildings or have other duties not related to the Building, only the allocable portion of such person or persons salary shall be included in Operating Expenses; 

  

	(c)	interest on debt or principal amortization payments (except as expressly otherwise provided) or any other payments on any mortgage or any payments under any ground
lease; 

  

	(d)	any fees, costs, and commissions incurred in procuring or attempting to procure other tenants including, but not necessarily limited to brokerage commissions, finders
fees, attorneys fees and expenses, entertainment costs and travel expenses; 

  

	(e)	any cost included in Operating Expenses representing an amount paid to a person, firm, corporation or other entity related to Landlord which is in excess of the amount
which would have been paid on an arms’-length basis in the absence of such relationship (provided that nothing herein shall be construed as requiring that the cost in question equal the lowest possible cost; only that the cost not be inflated
solely due to the absence of an arms’-length relationship); 

  

	(f)	any cost or expense which is applicable to or incurred for any parking garage or parking lots, or any costs of personnel used to park cars, collect money or provide
special security, and garage management fees; 

  

	(g)	depreciation of the Building or any part thereof; 

  

	(h)	replacement or contingency reserves; 

  

	(i)	legal, auditing, consulting and professional fees and other costs (other than those legal, auditing, consulting and professional fees and other costs incurred in
connection with the normal and routine maintenance and operation of the Building), including, without limitation, those: (i) paid or incurred in connection with financings, refinancings or sales of any Landlord’s interest in the Building
or University Park, (ii) relating to specific disputes with tenants, and (iii) relating to any special reporting required by securities laws; 

  

	(j)	penalty interest, late charges, penalties and similar charges associated with any failure by the Landlord and fulfill its obligations under this Lease;

  

	(k)	bad debt loss or rent loss; and 

  

	(l)	any cost incurred primarily as a consequence of the Landlord’s negligence or willful misconduct. 

  

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 Any costs related to the Common Areas shall, for the purposes of determining Operating
Expenses for the Property, be allocated to the Building based upon the methodology set forth in the Declaration of Covenants. 
 Payments by the Tenant for its share of the Tenant’s Operating Expenses Allocable to the Premises shall be made monthly at the time and in the fashion herein provided for tie payment of Annual Fixed Rent. The amount so to be paid to
the Landlord shall be an amount from time to time reasonably estimated by the Landlord to be sufficient to aggregate a sum equal to the Tenant’s share of the Tenant’s Operating Expenses Allocable to the Premises for each Operating Fiscal
Year. 
 Not later than one hundred twenty (120) days after the end of each Operating Fiscal Year or fraction thereof
during the Term or fraction thereof at the end of the Term, the Landlord shall render the Tenant a statement in reasonable detail and according to usual accounting practices certified by an officer of the Landlord, showing for the preceding
Operating Fiscal Year or fraction thereof, as the case may be, the Operating Expenses for the Property and Tenant’s Operating Expenses Allocable to the Premises. Said statement to be rendered to the Tenant also shall show for the preceding
Operating Fiscal Year or fraction thereof, as the case may be, the amounts of Operating Expenses already paid by the Tenant If at the time such statement is rendered it is determined with respect to any Operating Fiscal Year, that the Tenant has
paid (i) less than the entirety of the Tenant’s Operating Expenses Allocable to the Premises or (ii) more than the Tenant’s Operating Expenses Allocable to the Premises, then, in the case of (i) the Tenant shall pay to the
Landlord, as Additional Rent, within thirty (30) days of such statement the amounts of such underpayment and, in the case of (ii) the Landlord shall credit the amount of such overpayment against the monthly installments of the
Tenant’s Operating Expenses Allocable to the Premises next thereafter coining due (or refund such overpayment within thirty (30) days if the Term has expired to the extent that such overpayment exceeds any amount then due from the
Tenant to the Landlord). If the Commencement Date occurs on other than the first day of an Operating Fiscal Year, or if the Termination Date occurs on other than the last day of an Operating Fiscal Year, then the amount of Tenant’s Operating
Expenses Allocable to the Premises payable by the Tenant with respect to such Operating Fiscal Year(s) shall be pro-rated based upon the ratio of the length of the time period during such Operating Fiscal Year(s) in respect of which the Tenant has
an obligation to pay Tenant’s Operating Expenses Allocable to the Premises to the length of such Operating Fiscal Year. 
 The Tenant may examine or audit the accounts and original bills for Operating Expenses for the Property upon ten (10) days’ prior written notice to the Landlord, but no more often than one (1) time in any Operating Fiscal
Year; provided however, that if, during the course of any such examination or audit, the Tenant reasonably believes that it has discovered an error in the amount of Operating Expenses for the Property, the Tenant may review the accounts and bills
for the immediately two (2) preceding Operating Fiscal Years relating to the subject matter of such error. The Landlord agrees that it will make available to the Tenant in the Landlord’s office in University Park, during regular business
hours, such information as the Landlord has available at such office. In

  

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similar manner, the Tenant may examine such further records as the Landlord (or its affiliates) may have, but such matters will be conducted where the Landlord customarily keeps such records,
which may be at the headquarters of the Landlord’s parent company. The Tenant shall bear the cost of any such audit, unless the same discloses a discrepancy in excess of three percent (3%) of the Tenant’s Operating Expenses Allocable
to the Premises, in which event the Landlord shall reimburse the Tenant for such costs reasonably incurred. For any given Operating Fiscal Year of the Landlord, the Tenant must, except in connection with errors discovered during the course of an
examination, as provided above, make any such audit within twenty four (24) months after the Tenant’s receipt of itemized statements (and any supporting documentation requested by the Tenant) referred to in the preceding paragraph. The
Tenant must, except in connection with errors discovered during the course of an examination, as provided above, further make any claim for revision of Tenant’s Operating Expenses Allocable to the Premises for such Operating Fiscal Year by
written notice to the Landlord within said twenty four (24) month period. If the Tenant and the Landlord determine that Tenant’s Operating Expenses Allocable to the Premises are more or less than reported, either the Landlord shall provide
the Tenant with a refund or a credit against the next installment of Annual Fixed Rent and other charges or the Tenant shall pay the Landlord the amount of any underpayment within thirty (30) days of billing, provided that if the refund or
credit to which the Tenant is entitled relates to an error in Landlord’s statement of Tenant’s Operating Expenses Allocable to the Premises which overstates the Tenant’s Operating Expenses Allocable to the Premises by more than three
percent (3%), then interest at the Default Interest Rate accrue on any such discrepancy from the date of overpayment by the Tenant to the date the Tenant is credited or reimbursed in full therefor. The Landlord shall have no right to give the Tenant
any adjustment billing on account of Tenant’s Operating Expenses Allocable to the Premises incurred in any Operating Fiscal Year later than the date two (2) years after the expiration of such Operating Fiscal Year. 
 Section 3.4 Utility Charges. During the Term, the Tenant shall pay directly to the provider of the service, all charges for
steam, gas, electricity, fuel, water, sewer and other services and utilities furnished to the Premises and separately metered. 
 Section 3.5 Above-standard Services. If the Tenant requests and the Landlord elects to provide any services to the Tenant in addition to those described in Exhibit D), the Tenant shall pay to the Landlord, as Additional
Rent, the amount billed by Landlord for such services at Landlord’s standard rates as from time to time in effect, so long as such rates are consistent with comparable services in comparable buildings within the Cambridge market. If the Tenant
has requested that such services be provided on a regular basis, the Tenant shall, if requested by the Landlord, pay for such services at their actual cost to Landlord, including, without limitation, a reasonable overhead component, at the time and
in the fashion in which Annual Fixed Rent under this Lease is payable. Otherwise, the Tenant shall pay for such additional services within thirty (30) days after receipt of an invoice from the Landlord. 
 Section 3.6 No Offsets. Annual Fixed Rent and Additional Rent shall be paid by the Tenant without offset, abatement or deduction
except as provided herein. 
  

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 ARTICLE 4 
 ALTERATIONS 
 Section 4.1 Consent Required for
Tenant’s Alterations. The Tenant shall not make alterations or additions to the Premises except in accordance with the Tenant Design and Construction Manual, and with plans and specifications therefor first approved by the Landlord, which
approval shall not be withheld unreasonably, conditioned or delayed. Notwithstanding the foregoing, the Tenant may, from time to time without the Landlord’s prior consent and at the Tenant’s own expense, make interior non-structural
alterations and changes in and to the Premises, provided that such alterations or changes (i) do not diminish the value of the Building, (ii) are not incompatible with existing mechanical or electrical, plumbing, HVAC or other systems in
the Building, and (iii) do not affect the exterior appearance of the Building. Whether or not the Tenant’s changes and/or alterations require the Landlord’s consent pursuant to this paragraph, the Tenant shall, in each instance, give
reasonable prior notice to the Landlord of any alterations and changes in and to the Premises costing $50,000.00 or more which the Tenant intends to undertake, together with a reasonable description of the proposed work and such plans and
specifications, if any, as the Tenant has therefor and promptly following the performance of any alterations or additions to the Premises, the Tenant shall furnish Landlord an “as-built” set of plans and specifications for the Premises,
modified mechanical, electrical or plumbing work, specifying the alterations or additions in question, in each case in a fashion reasonably required by the Landlord, in addition to any other plans and specifications furnished by Tenant to Landlord
from time to time. The Landlord shall not be deemed unreasonable for withholding approval of any alterations or additions which (i) would, in the Landlord’s reasonable judgment, adversely affect any structural or exterior element of the
Building, (ii) would in the Landlord’s reasonable judgment, adversely affect the general utility of the Building for use by prospective future tenants thereof, (iii) would affect the exterior appearance of the Building in a manner
which is not acceptable to the Landlord, in its sole discretion, (iv) will require unusual expense to readapt the Premises to normal use as a biotechnology office and research and development facility unless the Tenant first gives assurance
acceptable to the Landlord that such readaptation will be made prior to such termination without expense to the Landlord; or (v) would not be compatible with existing mechanical or electrical, plumbing, HVAC or other systems in the Building, in
each case, as reasonably determined by the Landlord; provided,, however, that the Landlord shall specify in any notice withholding approval specifying, in reasonable detail, the nature of the Landlord’s objection, and if the Tenant shall, at
its sole cost and expense, cure the Landlord’s objections (in the Landlord’s reasonable judgment except in the case of the subject matter of clause (iii) above), then the Landlord shall not withhold its approval. If the Tenant shall
request the Landlord’s approval of proposed alterations under this Section 4.1, and the Landlord fails to respond to the Tenant’s request within ten (10) business days thereof, then the Landlord shall be deemed to have given its
approval thereto if Landlord fails to respond to the Tenant’s request within five (5) business days following the delivery to the Landlord of a written reminder notice, given by the Tenant on or following the expiration of the
aforementioned 10-day period, which reminder notice states the “deemed approval” consequences of failure to respond. Neither the Landlord’s failure to object to any proposed alterations or additions, nor the Landlord’s approval
of any plans and specifications furnished by Tenant to Landlord, shall be construed as superseding in any respect, or as a waiver of Landlord’s right to enforce, the Tenant’s obligation to fulfill all of the terms and conditions of this
Lease applicable to any work contemplated thereby. 
  

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 Notwithstanding anything to the contrary contained in this Section 4.1, if any of the
Tenant’s proposed alterations and/or additions affect the roof or the envelope of the Building, the following additional conditions shall apply: 
 (a) Such alterations and changes will not in any way interfere with the proper functioning of and Landlord’s access to equipment located on the roof of the Building; and 
 (b) Adequate measures are taken to screen and otherwise reduce the visibility and noise of such mechanical equipment,
antennae and dishes consistent with the appearance and design scheme required by the City of Cambridge and other structures in University Park. 
 Section 4.2 Ownership of Alterations. All alterations and additions shall be part of the Building and owned by the Landlord; provided, however, that the Landlord may require removal by the
Tenant of all or any portion of any alterations and additions made to the Premises, so long as the Landlord advised the Tenant of such requirement prior to the installation of the alteration or addition by the Tenant. If the Tenant fails to inform
the Landlord, in writing, at least ten (10) days prior to the installation of the alteration or addition, thereby preventing the Landlord from making a determination as to whether it will want such addition or alteration removed from the
Premises prior to its installation, then the Landlord shall advise the Tenant in writing of such determination within ten (10) days after the Tenant gives the Landlord written notice requesting that the Landlord make such determination. All
movable equipment, trade fixtures and furnishings not attached to the Premises shall remain the personal property of the Tenant and shall be removed by the Tenant upon termination or expiration of this Lease. Notwithstanding anything to the contrary
contained in this Section 4.2, any alterations and additions funded by the Landlord, and installed as part of the Initial Leasehold Improvements (as defined in the Work Letter) or otherwise (the “Landlord Funded Improvements”) and all
alterations and additions which are necessary for the use of the Premises as an operational biotechnology laboratory (the “Base Laboratory Improvements”), regardless of who funded their acquisition and installation, shall be part of the
Building and owned by the Landlord, and shall in no event constitute the Tenant’s personal property. For purposes of this Lease, “Base Laboratory Improvements” shall include equipment that is integrated into the Building which is
consistent with and necessary for the operation of a standard, high quality biotechnology research laboratory. Such equipment would include, but would not be limited to, supply and exhaust ventilation systems; fume hoods in reasonable quantity;
environmental rooms in reasonable quantity; laboratory benches in reasonable quantity, casework with associated shelving (whether fixed or adjustable or otherwise capable of being relocated) in reasonable quantity, fixtures, plumbing supply/waste
lines and equipment associated therewith, gas supply lines, a back-up electrical generator sufficient to meet critical power requirements, and similar improvements. Base Laboratory Improvements does not include stand-alone equipment such as
autoclaves, cagewashers, glasswashers, refrigerators, biosafety cabinets, NMR equipment, benchtop equipment, and similar equipment. 
  

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 Any alterations and additions which are neither Landlord Funded Improvements nor Base
Laboratory Improvements shall remain the property of the Tenant, and, if required to be removed upon the termination or expiration of this Lease as hereinabove provided, shall be removed by the Tenant with reasonable care and diligence, including
the capping off of all utility connections behind the adjacent interior finish, and the restoration of such interior finish to the extent necessary so that the Premises are left with complete wall, ceiling and floor finishes. 
 Section 4.3 Construction Requirements for Alterations. All construction work performed by or on behalf of the Tenant
(‘Tenant’s Work”), including without limitation any Initial Leasehold Improvements, shall be done in a good and workmanlike manner employing only first-class materials and in compliance with Landlord’s construction rules and
regulations and with all applicable laws and all lawful ordinances, regulations and orders of Governmental authority and insurers of the Building. The Landlord or Landlord’s authorized agent may (but without any implied obligation to do so)
inspect the work of the Tenant at reasonable times and shall give notice of observed defects. Tenant’s Work and the installation of furnishings shall always be coordinated in such manner as to maintain harmonious labor relations within
University Park and not to damage the Building or interfere with Building construction or operation. Tenant’s Work shall be performed by contractors or workmen first approved by the Landlord, which approval the Landlord agrees not to
unreasonably withhold or delay. The Landlord agrees to cooperate with the Tenant to develop a list of contractors and workmen (which may change, from time to time) who are mutually acceptable and are permitted to perform work in the Building. The
Tenant, before starting any work, shall receive and comply with the Landlord’s construction rules and regulations and shall cause the Tenant’s contractors to comply therewith, except in the case of the Initial Leasehold Improvements obtain
“builder’s risk” coverage (in an amount that is reasonable given the quality and quantity of the work to be undertaken) to enhance the insurance coverage otherwise required to be carried by the Tenant, secure all licenses and permits
necessary for such work, and deliver to the Landlord a statement of the names of its general contractor (or construction manager) and subcontractors who are to perform mechanical, electrical or plumbing work or are otherwise to perform work that
will affect the structure or base building systems of the Building, and the estimated cost of all labor and material to be furnished by them and security satisfactory to the Landlord in its reasonable discretion and consistent with the security
requirements for comparable work in comparable buildings in the Cambridge market protecting the Landlord against liens arising out of the furnishing of such labor and material; and cause each contractor to carry worker’s compensation insurance
in statutory amounts covering all the contractors’ and subcontractors’ employees and comprehensive general public liability insurance with limits (except as otherwise provided in the Work Letter with respect to Initial Leasehold
Improvements) of $1,000,000 (individual) and $5,000,000 (occurrence), or in such lesser amounts as Landlord may accept, covering personal injury and death and property damage (all such insurance to be written in companies approved reasonably by the
Landlord and insuring the Landlord, such individuals and entities affiliated with the Landlord as the Landlord may designate, any ground lessor or mortgagee that the Landlord may designate, and the Tenant as well as the contractors and to contain a
requirement for at least thirty (30) days’ notice to the Landlord prior to cancellation, nonrenewal or material change), and to deliver to the Landlord certificates of all such insurance. 
  

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 Section 4.4 Payment for Tenant Alterations. The Tenant agrees to pay promptly
when due the entire cost of any work done on the Premises by the Tenant, its agents, employees or independent contractors, and not to cause or permit any liens for labor or materials performed or furnished in connection therewith to attach to the
Premises or the Property and promptly to discharge or bond over any such liens which may so attach. If any such lien shall be filed against the Premises or the Property and the Tenant shall fail to cause such lien to be discharged, or bonded over,
within fifteen (15) days after receipt by the Tenant of notice of the filing thereof, the Landlord after a further five (5) days’ written notice may cause such lien to be discharged by payment, bond or otherwise without investigation
as to the validity thereof or as to any offsets or defenses which the Tenant may have with respect to the amount claimed. The Tenant shall reimburse the Landlord, as additional rent, for any cost so incurred and shall indemnify and hold harmless the
Landlord from and against any and all claims, costs, damages, liabilities and expenses (including reasonable attorneys’ fees) which may be incurred or suffered by the Landlord by reason of any such lien or its discharge. The Tenant’s
obligations under this Section 4.4 with respect to the Initial Leasehold Improvements that are, pursuant to the Work Letter, to be paid for with the proceeds of Landlord’s Contribution, are conditioned upon the Landlord’s payment to
the Tenant of Landlord’s Contribution in accordance with the Work Letter. 
 ARTICLE 5 
 RESPONSIBILITY FOR CONDITION OF BUILDING AND PREMISES 
 Section 5.1 Maintenance of Building and Common Areas by Landlord. Except as otherwise provided in Article 8, the Landlord shall make such repairs to the foundation system, roof, exterior walls
(including exterior glass), floor slabs, and any other structural elements of the Building as may be necessary to keep them in good order, condition and repair, and make such repairs to the mechanical systems and equipment serving the Building,
except for any mechanical systems and equipment that serve the Premises exclusively (“Tenant’s Dedicated Mechanical Systems and Equipment”), as are necessary to keep them in good order, condition and repair. The Landlord shall further
perform the services designated as Landlord’s Services on Exhibit D. Costs and expenses incurred by the Landlord under this Section 5.1 shall be included in Operating Expenses of the Property only as permitted under
Section 3.3. Subject to Section 7.5, the Tenant shall be responsible for 100% of the cost of any repair to the Premises, the Building, or the Land caused by the negligence or misconduct of the Tenant, or any agent, employee or contractor
of the Tenant, notwithstanding anything to the contrary provided in Section 3.3. 
 Section 5.2 Maintenance of
Premises by Tenant. The Tenant shall keep and maintain in good order, condition and repair the Premises and every part thereof and all of Tenant’s Dedicated Mechanical Systems and Equipment, reasonable wear and tear and damage by fire or
other casualty excepted (provided that subject to Section 7.5, the Landlord shall be responsible for damage caused by the fault or neglect of the Landlord, or the Landlord’s agents, employees or contractors), excluding those repairs for
which the Landlord is responsible pursuant to Sections 5.1, 8.1 and 8.5, and shall surrender the Premises and all alterations and additions thereto, at the end of the Term, in such condition, first removing all personal property of the Tenant and,
to the extent required pursuant to this Lease, all alterations and additions made by the Tenant, repairing any damage caused by such removal and restoring

  

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the Premises and leaving them in broom clean condition. If the Tenant elects to provide the Tenant-Provided Services, identified as such in Section 5.3, the Tenant shall perform the
Tenant-Provided Services promptly, as necessary and appropriate, with due diligence and in accordance with the standards therefor established under Section 5.3. The Tenant shall not permit or commit any damage (waste), and the Tenant shall,
subject to Section 7.5, be responsible for the cost of repairs which may be made necessary by reason of damage to the Property caused by the negligence or misconduct of the Tenant, or any of the contractors, employees, or agents of the Tenant.
Tenant’s Dedicated Mechanical Systems and Equipment, and all other laboratory systems and equipment, shall be maintained in good order, condition and repair consistent with prevailing standards at comparable first-class leased biotechnology
facilities, reasonable wear and tear, damage by fire or other casualty, and subject to Section 7.5, damage caused by the fault or neglect of the Landlord, or the Landlord’s agents, employees, or contractors excepted. 
 Section 5.3 Tenant-Provided Services. Notwithstanding anything to the contrary contained in this Article 5, the Tenant may
choose to provide, at its own cost and expense, in lieu of the Landlord providing the same under this Lease, the building services specified in clauses H and I of Exhibit D, and such other services as the Landlord may approve in its
reasonable discretion. Such services which are paid for and provided by the Tenant are hereinafter referred to as the “Tenant-Provided Services.” The provision by Tenant of Tenant-Provided Services shall be subject to reasonable standards
imposed by Landlord for the purpose of assuring the fulfillment of the requirements of any ground lessee, mortgagee, tenant, governmental authority or other third party pertaining to the maintenance and operation of the Building in good order,
condition and repair and in compliance with all legal requirements. 
 Section 5.4 Delays in Landlord’s
Services. The Landlord shall not be liable to the Tenant for any compensation or reduction of rent by reason or inconvenience or annoyance or for loss of business arising from the necessity of the Landlord or its agents entering the Premises for
any purposes authorized in this Lease, or for repairing the Premises or any portion of the Building. In case the Landlord is prevented or delayed from making any repairs, alterations or improvements, or furnishing any services or performing any
other covenant or duty to be performed on the Landlord’s part, by reason of any External Cause, the Landlord shall not be liable to the Tenant therefor, nor, except as expressly otherwise provided in this Lease, shall the Tenant be entitled to
any abatement or reduction of rent by reason thereof, nor shall the same give rise to a claim in the Tenant’s favor that such failure constitutes actual or constructive, total or partial, eviction from the Premises. 
 The Landlord reserves the right to stop any service or utility system the Landlord provides or causes to be provided under this Lease (i.e.
exclusive of any Tenant-Provided Services or other obligations of the Tenant under this Lease) when necessary by reason of accident or emergency, or until necessary repairs have been completed; provided, however, that in each instance of stoppage,
the Landlord shall exercise reasonable diligence to eliminate the cause thereof. Except in case of emergency repairs, the Landlord will give the Tenant reasonable advance notice of the contemplated stoppage and will schedule contemplated stoppages
at times reasonably approved by the Tenant and will use reasonable efforts to avoid unnecessary inconvenience to the Tenant by reason thereof. To the extent that the Landlord is providing or causing to be provided heat, light or any utility or
service, in no event shall

  

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the Landlord have any liability to the Tenant for the unavailability of the same to the extent that such unavailability is caused by External Causes, provided, however, that the Landlord is
obligated to exercise reasonable efforts to restore such services or utility systems’ operation. The Landlord agrees to carry rent interruption insurance in commercially reasonable amounts which permits recovery within, to the extent reasonably
available, five (5) days after the insured peril. 
 If the unavailability of heat, light or any utility or service
provided or caused to be provided by the Landlord other than the unavailability of the same due to the Tenant’s acts or omissions renders all or any portion of the Premises untenantable for the Tenant’s use as permitted under this Lease,
and the Tenant ceases to occupy the same for the conduct of its business, the Tenant shall receive an equitable abatement of rent, taking into account the extent of the Tenant’s loss of use of the Premises, following the condition of
untenantability on and after the day following the expiration of the deductible period provided in the Landlord’s rent interruption insurance policy. For all purposes of this Lease, if Tenant has responsibility for maintenance and repair of any
aspect of the Building or any equipment or system therein, the functioning and performance of the same shall be the responsibility of the Tenant under this Lease, and shall in no event constitute a service or utility system that the Landlord
provides or causes to be provided under this Lease. 
 Section 5.5 Tenant’s Responsibilities Regarding Hazardous
Materials. The Tenant covenants and agrees that the Tenant shall not use, generate, store or dispose, nor shall the Tenant suffer or permit the use, generation, storing or disposal in the Premises or otherwise by any of Tenant’s
contractors, licensees, invitees, agents or employees, of any oil, toxic substances, hazardous wastes or hazardous materials (collectively, “Hazardous Materials”) in on or about the Premises, the Building or the Land, except for Hazardous
Materials that are necessary for Tenant’s operation of Tenant’s Permitted Use, as set forth on Exhibit A, and in all cases such Hazardous Materials must be used, generated, stored and disposed of in compliance with all applicable
law and regulations. The Tenant covenants and agrees that the Tenant shall comply with all applicable laws and regulations and in handling and disposing of materials used in its research and other uses of the Premises, whether or not considered
Hazardous Materials, and no dumping, flushing or other introduction of Hazardous Materials or such other inappropriate materials into the septic, sewage or other waste disposal systems serving the Premises shall occur, except as specifically
permitted by law and subject to the conditions and qualifications imposed by any governmental license or permit. The Tenant shall provide to the Landlord copies of all licenses and permits that the Tenant has been required to obtain prior to the
handling of any such Hazardous Materials, and the Tenant must obtain all of such licenses and permits prior to the commencement of operations in the Premises requiring the same. From time to time during the Term of this Lease, and thereafter during
which the Tenant occupies any portion of the Premises, the Tenant shall provide the Landlord with such reasonable substantiation of the Tenant’s compliance with the requirements of this Section 5.5 and any additional requirements set forth
in Section 6.2 as the Landlord may reasonably request. The Tenant covenants and agrees that the Tenant shall, at its sole cost, promptly remove or remediate all Hazardous Materials that are found upon the Premises, the Building or the Land by
virtue of the failure of the foregoing covenants and agreements to have been fulfilled, or otherwise as the result of the act or omission of Tenant or its contractors, licensees, agents or employees, in a manner complying with all applicable laws
and

  

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regulations and the provisions of this Lease. If the Tenant should have any responsibility under this Section 5.5 to remove or remediate Hazardous Materials, the Tenant shall keep the
Landlord reasonably informed as to the status of the environmental condition at issue, promptly furnish to the Landlord copies of all regulatory filings with any governmental regulatory agencies in connection therewith, and substantiate the
performance of its obligations under this Section 5.5. 
 Section 5.6 Landlord’s Responsibilities Regarding
Hazardous Materials. During the Term of this Lease, if the removal or remediation of Hazardous Materials from the Premises, Building or Land is required to be undertaken, then except to the extent such obligation is the responsibility of the
Tenant under Section 5.5 hereof, the Landlord covenants and agrees to undertake the same without charge to the Tenant. Without limitation of the foregoing, if necessary to comply with any applicable legal requirements, should the existing
environmental condition of the Land require the removal or remediation of Hazardous Materials, the Landlord shall perform such removal or remediation, without charge to the Tenant, when and if required by applicable legal requirements. The Landlord
shall keep the Tenant reasonably informed as to the status of the environmental condition at issue, promptly furnish to the Tenant copies of all regulatory filings with any governmental regulatory agencies in connection therewith, and substantiate
the performance of its obligations under this Section 5.6. 
 If the Premises shall be rendered no longer reasonably
occupiable as a consequence of the presence of Hazardous Materials for which the Landlord is responsible for undertaking remediation under this Section 5.6, and the presence of such Hazardous Materials is introduced to the Premises by the
Landlord, then until the Premises is again reasonably occupiable, the Annual Fixed Rent and Additional Rent shall be justly and equitably abated and reduced according to the nature and extent of the loss of use thereof suffered by the Tenant.

 Section 5.7 Cross Indemnification. Each of the Landlord and the Tenant shall defend and indemnify the other and
hold the other harmless from and against any damages, liability or expense associated with claims by governmental or other third parties arising out of the presence, removal or remediation of Hazardous Materials for which the indemnifying party is
responsible for removal or remediation under this Lease. 
 ARTICLE 6 
 TENANT COVENANTS 
 The Tenant covenants during the Term and for such further time as the Tenant occupies any part of the Premises: 
 Section 6.1 Permitted Uses. The Tenant shall occupy the Premises only for the Permitted Uses, and shall not injure or deface the Premises or the Property, nor permit in the Premises any auction sale. The Tenant shall give
written notice to the Landlord, within twenty (20) days prior to the Commencement Date and thereafter once annually within twenty (20) days of each anniversary of the Commencement Date, of any materials on OSHA’s right to know list or
which are subject to regulation by any other federal, state,

  

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municipal or other governmental authority and which the Tenant intends to have present at the Premises. The Tenant shall comply with all requirements of public authorities and of the Board of
Fire Underwriters in connection with methods of storage, use and disposal thereof although nothing herein shall prevent the Tenant from challenging the validity of such requirements. The Tenant shall not permit in the Premises any nuisance, or the
emission from the Premises of any reasonably objectionable noise, odor or vibration, nor use or devote the Premises or any part thereof for any purpose which is contrary to law or ordinance, or liable to invalidate or increase premiums (above those
normally incurred for Permitted Uses) for any insurance on the Building or its contents (unless the Tenant pays for any such increase in premiums and provided such actions do not interfere with the use and enjoyment of the Land by the Landlord,
other tenants, visitors or invitees of University Park) or liable to render necessary any alteration or addition to the Building, nor commit or permit any waste in or with respect to the Premises. 
 Section 6.2 Laws and Regulations. The Tenant shall comply with all federal, state and local laws, regulations, ordinances,
executive orders, federal guidelines, and similar requirements in effect from time to time, including, without limitation, City of Cambridge ordinances numbered 1005 and 1086 and any subsequently adopted ordinance for employment and animal
experimentation with respect to animal experiments and hazardous waste and any such requirements pertaining to employment opportunity, anti-discrimination and affirmative action. Tenant shall have the right to contest any notice of violation for any
of the foregoing by appropriate proceedings diligently conducted in good faith. 
 Section 6.3 Rules and Regulations;
Signs. The Tenant agrees to comply with such reasonable and non-discriminatorily enforced rules and regulations of general applicability (“Rules and Regulations”) as (i) may from time to time be made by the Landlord of which the
Tenant is given written notice, so far as the same relate to the use of the Building, the Land and the Tenant’s appurtenant parking privileges and (ii) may from time to time be promulgated under the Declaration of Covenants with respect to
all or any portion of University Park. The Tenant shall not obstruct in any manner any portion of the Property; and, except as set forth in this Lease, shall not permit the placing of any signs, curtains, blinds, shades, awnings or flagpoles, or the
like, visible from outside the Building. 
 Section 6.4 Safety Compliance. The Tenant shall keep the Premises
equipped with all safety appliances required by law or ordinance or any other regulations of any public authority because of the manner of use made by the Tenant and to procure all licenses and permits so required because of such manner of use and,
if requested by the Landlord, do any work so required because of such use, it being understood that the foregoing provisions shall not be construed to broaden in any way the Tenant’s Permitted Uses. Tenant shall conduct such periodic tests,
evaluations or certifications of safety appliances and laboratory equipment as are required or recommended in accordance with generally accepted standards for good laboratory practice to ensure that such safety appliances and equipment remain in
good working order, and shall, upon Landlord’s reasonable request but not more often than two (2) times in any calendar year, provide to Landlord copies of such reports, evaluations and certifications. 
  

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 Section 6.5 Landlord’s Entry. The Tenant shall permit the Landlord and it
agents, after at least twenty four (24) hours’ notice except in the case of emergencies, to enter the Premises at all reasonable hours for the purpose of inspecting or making repairs to the same, monitoring Tenant’s compliance with
the requirements and restrictions set forth in this Lease, and for the purpose of showing the Premises to prospective purchasers and mortgagees at all reasonable times and to prospective tenants within twelve (12) months of the end of the Term
provided that in connection with such entry, Tenant may provide procedures reasonably designed so as not to jeopardize Tenant’s trade secrets, proprietary technology or critical business operations, including accompaniment of all such persons
by an employee of the Tenant. In case of an emergency, the Landlord shall make good faith efforts to notify the Tenant in person or by telephone prior to such entry, and in any event, the Landlord shall notify Tenant promptly thereafter such entry.

 Section 6.6 Floor Load. The Tenant shall not place a load upon any floor in the Premises exceeding the floor load
per square foot of area which such floor was designed to carry, and which is allowed by law. The Tenant’s machines and mechanical equipment shall be placed and maintained by the Tenant at the Tenant’s expense in settings sufficient to
absorb or prevent vibration or noise that may be transmitted to the Building structure. 
 Section 6.7 Personal Property
Tax. The Tenant shall pay promptly when due all taxes which may be imposed upon personal property (including, without limitation, fixtures and equipment) in the Premises to whomever assessed. Tenant shall have the right to contest the validity
or amount of any such taxes by appropriate proceedings diligently conducted in good faith. 
 Section 6.8 Assignment and
Subleases. The Tenant shall not assign this Lease or sublet (which term, without limitation, shall include granting of concessions, licenses and the like) the whole or any part of the Premises, nor permit the further underletting or assignment
of any sublease or other occupancy agreement (each a “Transfer”) without, in each instance, having first received the consent of the Landlord which consent shall not be unreasonably withheld or delayed, except in the case of Permitted
Transfers, with respect to which the Landlord’s consent shall not be required so long as a condition constituting an Event of Default is not then subsisting. In no event shall any of the Tenant’s rights with respect to the roof of the
Building, if any, be assigned or sublet other than in connection with a Transfer of the whole or any part of the Premises for purposes of enabling the transferee to occupy the same for the conduct of its business therein (provided that the occupancy
of part of the Premises in service of a business the substantial orientation of which is roof communications shall not qualify as such an occupancy), or to a service provider using such roof rights exclusively for the purpose of providing services
to the Tenant in connection with the conduct of the Tenant’s business (other than a communications business). Any purported Transfer made without such consent or otherwise not fulfilling the conditions and requirements of this Section 6.8
shall be void, and except as specifically permitted in this Section 6.8, in no event shall, the Tenant or anyone claiming by, through or under the Tenant have the right to mortgage, pledge, hypothecate or otherwise transfer this Lease. The
Landlord shall not be deemed to be unreasonable in withholding its consent to any proposed Transfer that is subject to the Landlord’s consent based on any of the following factors: 
 (a) If the manner in which the proposed occupant conducts its business operations is not consistent, in Landlord’s
reasonable opinion, with the image and character of the University Park development as a first-class office/research and development park, then the withholding of consent by the Landlord shall be considered reasonable and 
  

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 (b) If the proposed Transfer is (i) an assignment of this Lease, or
(ii) a sublease where as a result of the consummation of such sublease, the then Tenant shall no longer be in occupancy of at least sixty five percent (65%) of the rentable floor area of the Premises (e.g. any sublease that would result in
more than thirty five percent (35%) of the rentable floor area of the Premises being subject to a sublease, subleases or other occupancy agreements), then in either of such cases, if the proposed occupant is not sufficiently creditworthy in the
reasonable opinion of the Landlord with reference to the obligations which are to be fulfilled by the tenant under this Lease, and the reasonable needs of the Landlord to protect the value of the Building, then the withholding of consent by the
Landlord shall be considered reasonable. 
 If the proposed occupant is already involved in discussions with either the Landlord
or any affiliate of the Landlord regarding space within University Park that is or is to become available for lease, then the withholding of consent by the Landlord shall be considered reasonable. 
 Notwithstanding anything to the contrary contained in this Section, Tenant shall have the right to assign or otherwise transfer this Lease
or the Premises, or part of the Premises, without obtaining the prior consent of Landlord, (a) to an entity owning a majority of Tenant or to a majority owned subsidiary or to an entity which is majority owned by the same entity which owns a
majority of Tenant (any of the foregoing being referred to herein as a “Tenant Affiliate”), provided that (i) the transferee shall, subject to applicable law, regulation or prior binding agreement, prior to the effective date of the
transfer, deliver to Landlord instruments evidencing such transfer and its agreement to assume and be bound by all the terms, conditions and covenants of this Lease to be performed by Tenant, all in form reasonably acceptable to Landlord, and
(ii) at the time of such transfer there shall not be an uncured Event of Default under this Lease; or (b) to the purchaser of at least fifty percent (50%) of its assets or stock, or to any entity into which the Tenant may be merged or
consolidated (along with all or substantially all of its assets) (the “Acquiring Company”), provided that (i) the net worth of the Acquiring Company upon the consummation of the transfer or merger shall not be less than the net worth
of the Tenant at the time immediately prior to such transfer or merger, (ii) the Acquiring Company continues to operate the business conducted in the Premises consistent with the Permitted Uses described in Exhibit A hereto, (iii) the
Acquiring Company shall assume in writing, in form reasonably acceptable to Landlord, all of Tenant’s obligations under this Lease, (iv) Tenant shall provide to Landlord such additional information regarding the Acquiring Company as
Landlord shall reasonably request, and (v) Tenant shall pay Landlord’s reasonable out-of-pocket expenses incurred in connection therewith. Unless Landlord shall have objected to such assignment or transfer by Tenant within ten
(10) business days following Landlord’s receipt of the information or items described in (b)(i) and (iii) above, then Landlord shall be deemed to have waived its right to object thereto. Each of the transfers described in this
paragraph is referred to hereinafter as “Permitted Transfers.” In no event shall any transaction consummated for the purpose of evading Tenant’s obligation to obtain Landlord’s consent under this Section 6.8 be construed as
a Permitted Transfer, notwithstanding that such transaction otherwise qualifies as a Permitted Transfer. 
  

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 Whether or not the Landlord consents, or is required to consent, to any Transfer, the Tenant
named herein shall remain fully and primarily liable for the obligations of the Tenant hereunder, including, without limitation, the obligation to pay Annual Fixed Rent and Additional Rent provided under this Lease. 
 The Tenant shall give the Landlord notice of any proposed Transfer (other than a Permitted Transfer), specifying the provisions thereof,
including (i) the name and address of the proposed occupant, subtenant, assignee, mortgagee or other transferee, (ii) a copy of the proposed occupant’s, subtenant’s, assignee’s, mortgagee’s or other transferee’s
most recent annual financial statement, and (iii) all of the terms and provisions upon which the proposed Transfer is to be made including, without limitation, all of the documentation effectuating such Transfer (which shall be subject to the
Landlord’s approval not to be unreasonably withheld) and such other reasonable information concerning the proposed Transfer or concerning the proposed occupant, subtenant, assignee, mortgagee or other transferee as the Tenant has obtained in
connection with the proposed Transfer. The Tenant shall reimburse the Landlord promptly for reasonable legal and other reasonable expenses incurred by the Landlord in connection with any request by the Tenant for consent to any Transfer. If this
Lease is assigned, or if the Premises or any part thereof is sublet or occupied by anyone other than the Tenant, or there is otherwise a Transfer, then during any time when an Event of Default is subsisting, the Landlord may, at any time and from
time to time, collect rent and other charges from the assignee, sublessee, occupant, mortgagee or transferee, and apply the net amount collected to the rent and other charges herein reserved, but no such assignment, subletting, occupancy or
collection shall be deemed a waiver of the prohibitions contained in this Section 6.8 or the acceptance of the assignee, sublessee or occupant as a tenant or a release of the Tenant from the further performance by the Tenant of covenants on the
part of the Tenant herein contained. 
 The Tenant shall pay to the Landlord fifty percent (50%) of any amounts the Tenant
receives from any occupant, subtenant, assignee or other transferee other than a Permitted Transferee, as rent, additional rent or other forms of compensation or reimbursement (if any) in excess of the aggregate amount of (i) the proportionate
monthly share of Annual Fixed Rent, Additional Rent and all other monies due to Landlord pursuant to this Lease (allocable in the case of a sublease to that portion of the Premises being subleased), (ii) brokerage commissions and fees for legal
services associated with the transaction, (iii) any expenses incurred by the Tenant in connection with preparing the Premises or applicable portion thereof for occupancy by such subtenant, assignee or other transferee and (iv) any monetary
concessions paid to the subtenant, assignee or other transferee such as, but not limited to, reimbursement of moving expenses (collectively “Sublease Transaction Expenses”). In the circumstances where the transferee pays the consideration
due to the Tenant on account of such transfer over time (e.g. monthly rental payments under a sublease), Sublease Transaction Expenses shall be amortized on a straight-line basis over the term of the transfer in question, together with interest at a
rate which is reasonably satisfactory to the Landlord. Neither the fact that the Landlord’s consent may not be required in order for the

  

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Tenant to effectuate a Permitted Transfer, nor the consent by the Landlord to a Transfer for which the Landlord’s consent is required shall be construed to relieve the Tenant from the
obligation to obtain the express consent in writing of the Landlord to any further Transfer whether by the Tenant or by anyone claiming by, through or under the Tenant including, without limitation, any occupant, assignee, subtenant, mortgagee or
other transferee, excluding any Permitted Transfer. 
 The Landlord may elect, within thirty (30) days of receipt of
written notice from the Tenant of any proposed assignment of this Lease prior to approving or disapproving any such proposed assignment, to repossess the Premises. The Landlord may thereafter lease the Premises in such a manner as the Landlord may
in its sole discretion determine. In the event the Landlord elects to repossess the Premises as provided above, then all of the Tenant’s rights and obligations hereunder with respect to the Premises shall cease and shall be of no further force
and effect. The provisions of this paragraph shall not apply to Permitted Transfers. 
 If the Landlord withholds consent to a
proposed Transfer, in any case where the Landlord is bound by this Lease not to unreasonably withhold such consent, and the Tenant disputes the reasonability of the Landlord’s withholding of such consent, then either party may, at its election,
have the dispute resolved by the Expedited Dispute Resolution Procedure, The Landlord shall have no liability for having unreasonably withheld consent to such a Transfer provided that the Landlord may be required to give such consent pursuant to the
Expedited Dispute Resolution Procedure. 
 ARTICLE 7 
 INDEMNITY AND INSURANCE 
 Section 7.1
Indemnity. The Tenant shall indemnify and save harmless the Landlord and the Landlord’s ground lessees, mortgagees and managing agent for the Building from and against all claims, loss, or damage of whatever nature arising from
(i) any breach by Tenant of any obligation of Tenant under this Lease, or (ii) any negligence or misconduct of the Tenant, or the Tenant’s contractors, licensees, agents, servants or employees, or (iii) any accident, injury or
damage whatsoever caused to any person or property in the Building or on or about the Land, occurring after the Commencement Date (or such earlier date upon which the Tenant first commences occupancy of all or any part of the Premises) and until the
end of the Term and thereafter, so long as the Tenant is in occupancy of any part of the Premises, provided that the foregoing indemnity, shall not include any claims, loss or damage to the extent arising from any negligence or misconduct of the
Landlord, or the Landlord’s contractors, licensees, agents, servants or employees or the Landlord’s ground lessees, mortgagees or managing agent for the Building. 
 The Landlord shall indemnify and save harmless the Tenant from and against all claims, loss, or damage of whatever nature arising from
(i) any breach by Landlord of any obligation of Landlord under this Lease or (ii) from any negligence or misconduct of the Landlord, or the Landlord’s contractors, licensees, agents, servants or employees, provided that the foregoing
indemnity shall not

  

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include any claims, loss or damage to the extent arising from any act, omission or negligence of the Tenant, or the Tenant’s contractors, licensees, agents, servants or employees, occurring
following the Commencement Date and until the expiration of earlier termination of the Term of this Lease. 
 The foregoing
indemnity and hold harmless agreements shall include indemnity against reasonable attorneys’ fees and all other costs, expenses and liabilities incurred in connection with any such claim or proceeding brought thereon, and the defense thereof,
but shall be subject to the limitations specified in Sections 7.5 and 12.16. 
 Section 7.2 Liability Insurance. The
Tenant agrees to maintain in full force from the Commencement Date (or such earlier date upon which the Tenant first commences occupancy [as distinguished from construction of Initial Leasehold Improvements by the Contractor (as defined in the Work
Letter)] of all or any part of the Premises), throughout the Term, and thereafter, so long as the Tenant is in occupancy of any part of the Premises, a policy of commercial general liability insurance under which the Landlord (and any individuals or
entities affiliated with the Landlord, any ground lessor and any holder of a mortgage on the Property of whom the Tenant is notified by the Landlord) are named as additional insureds, and under which the insurer provides a contractual liability
endorsement insuring against all cost, expense and liability arising out of or based upon any and all claims, accidents, injuries and damages described in Section 7.1, in the broadest form of such coverage from time to time available. Each such
policy shall be noncancelable and nonamendable (to the extent that any proposed amendment reduces the limits or the scope of the insurance required in this Lease) with respect to the Landlord and such ground lessors and mortgagees without thirty
(30) days’ prior notice to the Landlord and such ground lessors and mortgagees and at the election of the Landlord, either a certificate of insurance or a duplicate original policy shall be delivered to the Landlord. The minimum limits of
liability of such insurance as of the Commencement Date shall be Ten Million Dollars ($10,000,000.00) for combined bodily injury (or death) and damage to property (per occurrence) with an aggregate annual limit of liability of Ten Million Dollars
($10,000,000.00), and from time to time during the Term such limits of liability shall be increased to reflect such higher limits as are customarily required pursuant to new leases of space in the Boston-Cambridge area with respect to similar
properties. Such insurance may be effected with a combination of a base commercial general liability policy and umbrella insurance. 
 Section 7.3 Personal Property at Risk. The Tenant agrees that all of the furnishings, fixtures, equipment, effects and property of every kind, nature and description of the Tenant and of all persons claiming by, through or under
the Tenant which, during the continuance of this Lease or any occupancy of the Premises by the Tenant or anyone claiming under the Tenant which, during the continuance of this Lease or any occupancy of the Premises by the Tenant or anyone claiming
under the Tenant, may be on the Premises or elsewhere in the Building or on the Property or parking facilities provided hereby, shall be at the sole risk and hazard of the Tenant, and if the whole or any part thereof shall be destroyed or damaged by
fire, water or otherwise, or by the leakage or bursting of water pipes, steam pipes, or other pipes, by theft or from any other cause, no part of said loss or damage is to be charged to or be borne by the Landlord, except that the Landlord shall in
no event be exonerated from any liability to the Tenant or to any person, for any injury, loss, damage or liability to the extent caused by Landlord’s or its employees’, agents’ or contractors’ negligence or willful misconduct.

  

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 Section 7.4 Landlord’s Insurance. The Landlord shall, from and after the
Commencement Date and until the expiration or earlier termination of the Term of this Lease, carry such “all risk” casualty in an amount equal to at least the replacement cost for the Building with a deductible in amounts carried at
comparable buildings with similar uses within the Cambridge market or required by any mortgagee holding a mortgage thereon or any ground lessor of the Land, in an amount equal to the replacement cost of the Building, including all leasehold
improvements, exclusive of foundations, site preparation and other nonrecurring construction costs. The Landlord shall also, during the aforesaid period, carry commercial general liability insurance with the same limits which the Tenant is required
to carry from time to time upon and with respect to operations at the Building, which shall similarly be noncancellable and nonamendable (to the extent that any proposed amendment reduces the limits or the scope of insurance required in this Lease)
with respect to the Tenant without thirty (30) days’ prior notice to the Tenant. 
 Section 7.5 Waiver of
Subrogation. Any casualty insurance carried by either party with respect to the Building, Land, Premises, parking facilities or any property therein or occurrences thereon shall, without further request by either party, include a clause or
endorsement denying to the insurer rights of subrogation against the other party (and the Landlord’s policy shall also deny the insurer rights of subrogation against any permitted subtenant and any such subtenant shall be required to carry a
policy that denies the insurer rights of subrogation against the Landlord) to the extent rights have been waived by the insured prior to occurrence of injury or loss. Each party, notwithstanding any provisions of this Lease to the contrary, hereby
waives any rights of recovery against the other (and the Landlord hereby waives any right of recovery which the Landlord has against any permitted subtenant, and any sublease will require that the subtenant waive any right of recovery which any such
subtenant may have against the Landlord) for loss or damage to property, including, without limitation, loss or damage caused by negligence of such other party, due to hazards covered by casualty insurance which such party is required to carry
hereunder, except with respect to any damage within the deductible under such insurance policy. 
 Section 7.6 Policy
Requirements. Any required insurance may be in the form of blanket coverage, so long as the coverage required herein is maintained. Each party shall cause a certificate, providing such information as reasonably requested by the other party,
evidencing the existence and limits of its insurance coverage with respect to the Premises and the Building, as the case may be, to be delivered to such other party upon the commencement of the Term. Thereafter, each party shall cause similar
certificates evidencing renewal policies to be delivered to such other party at least thirty (30) days prior to the expiration of the term of each policy and at such other times as reasonably requested by the other party. The insurance policies
and certificates required by this Article 7 shall contain a provision requiring the insurance company to furnish Landlord and Tenant, as the case may be, thirty (30) days’ prior written notice of any cancellation or lapse, or the effective
date of any reduction in the amounts or scope of coverage. The Landlord shall have reasonable approval over the identity of the Tenant’s insurance underwriter. 
  

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 ARTICLE 8 
 CASUALTY AND EMINENT DOMAIN 
 Section 8.1
Restoration Following Casualties. If, during the Term, the Building or the Premises shall be damaged by fire or casualty, subject to termination rights of the Landlord and the Tenant provided below in this Article 8, the Landlord shall
proceed promptly to exercise diligent efforts to restore, or cause to be restored, the Building to substantially the condition thereof just prior to time of such damage, but the Landlord shall not be responsible for delay in such restoration which
may result from External Causes. Provided that the Landlord complies with its obligations to carry casualty insurance in accordance with Section 7.4, the Landlord shall have no obligation to expend in the reconstruction of the Building more
than the sum of the amount of any deductible and the actual amount of insurance proceeds made available to the Landlord by its insurer, and any additional costs associated with changes to the Premises desired by the Tenant and permitted by Article 4
shall be paid by the Tenant in the manner reasonably required by the Landlord. Any restoration of the Building or the Premises shall be altered to the extent necessary to comply with then current and applicable laws and codes. The Landlord shall, as
soon as possible after any casualty, but in any event no later than sixty (60) days after such casualty, provide to the Tenant a reasonable written estimate (“Architect’s Estimate”) from a reputable architect or other design
professional as to the time frame within which the Landlord will be able to repair the casualty damage and the cost of repairing such damage, and the Landlord’s reasonable determination (“Insurance Proceeds Estimate”) as to the amount
of insurance proceeds which will be available to repair such damage. 
 Section 8.2 Landlord’s Termination
Election. If the Landlord reasonably determines, based upon the Architect’s Estimate and the Insurance Proceeds Estimate, that (a) the amount of insurance proceeds available to the Landlord is insufficient (by more than the amount of
any deductible) to cover the cost of restoring the Building by more than the amount of any deductible (provided however, that the Landlord shall not have the right to terminate the Lease pursuant to this clause (a) if the casualty would have
been covered by casualty insurance which the Landlord is required to obtain pursuant to Section 7.4), or (b) the Landlord will be unable to restore the Building within twelve (12) months from the date of such casualty, then the
Landlord may terminate this Lease by giving notice to the Tenant at the time that the Landlord provides to the Tenant the Architect’s Estimate and the Insurance Proceeds Estimate. Any such termination shall be effective on the date designated
in such notice from the Landlord, but in any event not later than sixty (60) days after such notice, and if no date is specified, effective upon the delivery of such notice. Failure by the Landlord to give the Tenant notice of termination
within ninety (90) days following the occurrence of the casualty shall constitute the Landlord’s agreement to restore the Building as contemplated in Section 8.1. 
 Section 8.3 Tenant’s Termination Elections. If, based upon the Architect’s Estimate and the Insurance Proceeds
Estimate, the time period for repairing any casualty damage will exceed twelve (12) months after the date of any casualty, then the Tenant shall have the right, exercisable by written notice given on or before the date thirty (30) days
after the Landlord gives to the Tenant the Architect’s Estimate and the Insurance Proceeds Estimate, to terminate this Lease. 
  

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 If neither the Landlord nor the Tenant exercise their termination rights based upon the
Architect’s Estimate and the Insurance Proceeds Estimate, but the Landlord has failed to restore the Building, within twelve (12) months from the date of the casualty or taking, such period to be subject, however, to extension (which
extension shall not exceed an additional one hundred eighty (180) days) where the delay in completion of such work is due to External Causes, the Tenant shall have the right to terminate this Lease at any time after the expiration of such
12-month period (as extended by delay due to External Causes as aforesaid), as the case may be, until the restoration is substantially completed, such termination to take effect as of the date of the Tenant’s notice. However, if the Landlord
has been diligently prosecuting the repair of all casualty and damage, and if the Landlord reasonably determines at any time, and from time to time, during the restoration, based upon certification by its architect or other design professional, that
such restoration will not be able to be completed before the deadline date after which the Tenant may terminate this Lease under this Section 8.3, and the Landlord specifies in a notice to Tenant to such effect a later date that the Landlord
estimates will be the date upon which such restoration will be completed, then the Tenant may terminate this Lease within thirty (30) days of the Landlord’s notice as aforesaid, failing which the deadline date shall be extended to the date
set forth in Landlord’s notice (as extended by delay due to External Causes as aforesaid). The Landlord shall exercise reasonable efforts to keep the Tenant advised of the status of restoration work from time to time, and promptly following any
request for information during the course of the performance of the restoration work. 
 Section 8.4 Casualty at
Expiration of Lease. If the Premises shall be damaged by fire or casualty in such a manner that the Premises cannot, in the ordinary course, reasonably be expected to be repaired within one hundred twenty (120) days from the commencement of
repair work and such damage occurs within the last twenty four (24) months of the Term (as the same may have been extended prior to such fire or casualty), either party shall have the right, by giving notice to the other not later than sixty
(60) days after such damage, to terminate this Lease, whereupon this Lease shall terminate as of the date of such notice. Notwithstanding the foregoing, the Landlord shall not have the right to terminate this Lease as aforesaid provided that
the Tenant shall have exercised its right to extend the Term of this Lease pursuant to Section 2.6 hereof not later than forty-five (45) days after the date of damage to the Premises. 
 Section 8.5 Eminent Domain. Except as hereinafter provided, if the Premises, or such portion thereof as to render the balance
(if reconstructed to the maximum extent practicable in the circumstances) unsuitable for continued occupancy for the purposes contemplated under this Lease, shall be taken by condemnation or right of eminent domain, and the Landlord and the Tenant
shall each have the right to terminate this Lease by notice to the other of its desire to do so, provided that such notice is given not later than thirty (30) days after receipt by the Tenant of notice of the effective date of such taking. If
so much of the Building shall be so taken that the Landlord reasonably determines, in good faith, that it would be necessary to substantially alter the Building so that a rebuilt Building will not be substantially similar to the Building before such
taking, the Landlord shall have the right to terminate this Lease by giving notice to the Tenant of the Landlord’s desire to do so not later than thirty (30) days after the effective date of such taking. 
  

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 Should any part of the Premises be so taken or condemned during the Term, and should this
Lease be not terminated in accordance with the foregoing provisions, the Landlord agrees to use reasonable efforts to put what may remain of the Premises into proper condition for use and occupation as nearly like the condition of the Premises prior
to such taking as shall be practicable, subject, however, to applicable laws and codes then in existence. The Landlord shall have no obligation to expend in the aforesaid restoration more than the proceeds of any award received in any condemnation
or eminent domain proceeding, or any sum paid in lieu thereof. 
 Section 8.6 Rent After Casualty or Taking. If the
Premises shall be damaged by fire or other casualty, until the Lease is terminated or the Premises is restored, the Annual Fixed Rent and Additional Rent shall be justly and equitably abated and reduced according to the nature and extent of the loss
of use thereof suffered by the Tenant. In the event of a taking which permanently reduces the area of the Premises, a just proportion of the Annual Fixed Rent and applicable Additional Rent shall be abated for the remainder of the Term. 

Section 8.7 Temporary Taking. In the event of any taking of the Premises or any part thereof for a temporary use not in
excess of twelve (12) months, (i) this Lease shall be and remain unaffected thereby and Annual Fixed Rent and Additional Rent shall not abate, and (ii) the Tenant shall be entitled to receive for itself such portion or portions of any
award made for such use with respect to the period of the taking which is within the Term. 
 Section 8.8 Taking
Award. Except as otherwise provided in Section 8.7, the Landlord shall have and hereby reserves and accepts, and the Tenant hereby grants and assigns to the Landlord, all rights to recover for damages to the Building and the Land, and the
leasehold interest hereby created, and to compensation accrued or hereafter to accrue by reason of such taking, damage or destruction, as aforesaid, and by way of confirming the foregoing, the Tenant hereby grants and assigns to the Landlord, all
rights to such damages or compensation. Nothing contained herein shall be construed to prevent the Tenant from prosecuting in any condemnation proceedings a claim for relocation expenses and improvements made by the Tenant in the Premises that
constitute Tenant’s personal property, including the Removable Alterations. 
 Section 8.9 Casualty or Eminent
Domain Affecting Parking Privileges. If, during the Term, there shall be damage by fire or casualty, or a taking by condemnation or right of eminent domain, that results in the Landlord reducing the number of Parking Passes that permit the
Tenant to park in parking spaces within University Park (a “University Park Parking Privileges Reduction”), then notwithstanding anything to the contrary provided in Exhibit A, the Landlord may substitute alternative parking
arrangements (‘Temporary Substitute Parking Arrangements”) within a one-mile radius of University Park that will provide parking areas with respect to which the Tenant may (using the Parking Passes that may no longer be used for parking
within University Park) enjoy the parking privileges contemplated hereby, provided that any such alternative parking areas shall be reasonably well lit, and there shall be provided shuttle bus transportation to and from University Park from such
alternative parking areas, on terms reasonably satisfactory to the Tenant. The Landlord’s furnishing of Temporary Substitute Parking Arrangements shall constitute a satisfactory curing of the adverse effects of a University Park Parking
Privileges Reduction, subject to the further provisions of this Section 8.9 below. 
  

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 The Landlord hereby covenants and agrees that any University Park Parking Privileges
Reduction shall be made on a fair and equitable basis with respect to all of the tenants in University Park. The Landlord shall, within one hundred twenty (120) days of any fire, casualty or taking affecting parking facilities within University
Park that results in a University Park Parking Privileges Reduction, give the Tenant written notice (“Parking Notice”) (i) describing to what extent the Landlord will be able to provide Temporary Substitute Parking Arrangements that
fulfill the requirements of the immediately prior paragraph of this Section 8.9 and (ii) providing an estimate of the likely duration of such University Park Parking Privileges Reduction. The Landlord shall, in the Parking Notice,
designate the number of affected Parking Passes and the location of the substitute parking areas, and cooperate with the Tenant to establish reasonably satisfactory terms for shuttle bus transportation, as soon as reasonably possible following the
occurrence of an event resulting in a University Park Parking Privileges Reduction. 
 If the Landlord (i) does not, in the
Parking Notice, make Temporary Substitute Parking Arrangements within one hundred twenty (120) days of the commencement of a University Park Parking Privileges Reduction that fulfill the requirements of the first paragraph of this
Section 8.9 with respect to at least fifty percent (50%) of the Parking Passes to which the Tenant is entitled under this Lease, (ii) specifies in the Landlord’s estimate of the likely duration of the University Park Parking
Privileges Reduction that the period during which the Tenant must suffer a reduction of more man fifty percent (50%) of its Parking Passes (i.e., not replaced through Temporary Substitute Parking Arrangements) will exceed one (1) year, or
(iii) specifies in the Landlord’s estimate of the likely duration of the University Park Parking Privileges Reduction that the period during which a University Park Parking Privileges Reduction will exist will likely exceed twenty four
(24) months, then the Tenant shall have the right, exercisable upon written notice to the Landlord within thirty (30) days after the Tenant receives the Parking Notice, to terminate this Lease. 
 If the Tenant does not exercise its termination right, as aforesaid, then the Landlord shall, to the extent practicable, proceed promptly
after the occurrence of a University Park Parking Privileges Reduction affecting the Tenant to restore, or cause to be restored, sufficient parking areas in University Park to permit the Tenant to have the number of Parking Passes contemplated in
Exhibit A to be able to be used in parking areas within University Park. However, if the Landlord is unable to so restore the Tenant’s parking privileges within University Park within twenty four (24) months from the date of the
University Park Parking Privileges Reduction, then the Tenant shall have the right to terminate this Lease by notice to the Landlord of its desire to do so, provided such notice is given not later than thirty (30) days after the Landlord
notifies the Tenant as aforesaid. 
 The Tenant’s termination rights set forth in this Section 8.9 shall be the
Tenant’s sole remedy for the Landlord’s inability to provide the parking privileges contemplated under this Lease in the event of a casualty or taking affecting parking in University Park, provided that the Landlord has complied with its
obligation to act on a fair and equitable basis. Any such termination of this Lease by the Tenant, as aforesaid, shall be effective thirty (30) days after notice is so given to the Landlord, or such later date specified by the Tenant in such
termination notice not exceeding one hundred eighty (180) days after termination notice is given. Failure by the Tenant to timely exercise any right to terminate this Lease under this Section 8.9 shall result in the waiver by the Tenant of
any such right to terminate this Lease. 
  

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 ARTICLE 9 
 DEFAULT 
 Section 9.1 Tenant’s
Default. Each of the following shall constitute an Event of Default: 
 (a) Failure on the part of the Tenant
to pay the Annual Fixed Rent, Additional Rent or other charges for which provision is made herein on or before the date on which the same become due and payable, if such condition continues for ten (10) days after written notice that the same
are due. 
 (b) Failure on the part of the Tenant to perform or observe any other term or condition contained in
this Lease if the Tenant shall not cure such failure within thirty (30) days after written notice from the Landlord to the Tenant thereof, provided that in the case of breaches that are not reasonably susceptible to cure within thirty
(30) days through the exercise of due diligence, then so long as the Tenant commences such cure within thirty (30) days, and the Tenant diligently pursues such cure to completion, such breach shall not be deemed to create an Event of
Default. 
 (c) The taking of the estate hereby created on execution or by other process of law; or a judicial
declaration that the Tenant, or any guarantor of this Lease, is bankrupt or insolvent according to law; or any assignment of the property of the Tenant, or any guarantor of this Lease, for the benefit of creditors; or the appointment of a receiver,
guardian, conservator, trustee in bankruptcy or other similar officer to take charge of all or any substantial part of the property of Tenant, or any guarantor of this Lease, by a court of competent jurisdiction, which officer is not dismissed or
removed within ninety (90) days; or the filing of an involuntary petition against the Tenant, or any guarantor of this Lease, under any provisions of the bankruptcy act now or hereafter enacted if the same is not dismissed within ninety
(90) days; the filing by the Tenant, or any guarantor of this Lease, of any voluntary petition for relief under provisions of any bankruptcy law now or hereafter enacted. 
 If an Event of Default shall occur, then, in any such case, whether or not the Term shall have begun, the Landlord lawfully may, immediately
or at any time thereafter, give notice to the Tenant specifying the Event of Default and this Lease shall come to an end on the date specified therein as fully and completely as if such date were the date herein originally fixed for the expiration
of the Lease Term, and the Tenant will then quit and surrender the Premises to the Landlord, but the Tenant shall remain liable as hereinafter provided. 
  

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 Section 9.2 Damages. In the event that this Lease is terminated, the Tenant
covenants to pay to the Landlord punctually all the sums (“Periodic Payments”) and perform all the obligations which the Tenant covenants in this Lease to pay and to perform in the same manner and to the same extent and at the same time as
if this Lease had not been terminated, and all of the Landlord’s expenses in connection with reletting the Premises including, without limitation, all repossession costs, brokerage commissions, fees for legal services and expenses of preparing
the Premises for such reletting. However, the Landlord may elect, at any time, to demand in lieu of any further obligations to make Periodic Payments, and payments on account of the Landlord’s reletting costs thereafter accruing, as
compensation, an amount (the “Lump Sum Payment”) equal to the excess, if any, of the discounted present value of the total rent reserved for the then remainder of the Term over the then discounted present fair rental value of the Premises
for the then remainder of the Term. The discount rate for calculating such sum shall be the then current rate of United States Treasury securities having a maturity date as close as possible to the end of the Term (had the Lease not been
terminated). In calculating the rent reserved, there shall be included, in addition to the Annual Fixed Rent and all Additional Rent, the value of all other considerations agreed to be paid or performed by the Tenant over the remainder of the Term.

 In calculating the Periodic Payments to be made by the Tenant under the foregoing covenant, the Tenant shall be credited with
the net proceeds of any rent obtained by reletting the Premises, after deducting all the Landlord’s expenses in connection with such reletting, including, without limitation, all repossession costs, brokerage commissions, fees for legal
services and expenses of preparing the Premises for such reletting. The Landlord may (i) relet the Premises, or any part or parts thereof, for a term or terms which may, at the Landlord’s option, exceed or be equal to or less than the
period which would otherwise have constituted the balance of the Term, and may grant such concessions and free rent as the Landlord in its reasonable commercial judgment considers advisable or necessary to relet the same and (ii) make such
alterations, repairs and improvements in the Premises as the Landlord in its reasonable commercial judgment considers advisable or necessary to relet the same. No action of the Landlord in accordance with foregoing or failure to relet or to collect
rent under-reletting shall operate to release or reduce the Tenant’s liability. The Landlord shall be entitled to seek to rent other properties of the Landlord prior to reletting the Premises. Notwithstanding the foregoing, the Landlord shall
offer such Premises to lease in the same manner as the Landlord offers other vacant space for lease in University Park. 
 Section 9.3 Cumulative Rights. The specific remedies to which either party may resort under the terms of this Lease are cumulative and are not intended to be exclusive of any other remedies or means of redress to which it may be
lawfully entitled in case of any breach or threatened breach by the other party of any provisions of this Lease. In addition to the other remedies provided in this Lease, each party shall be entitled to seek the restraint by injunction of the
violation or attempted or threatened violation of any of the covenants, conditions or provisions of this Lease or to a decree compelling specific performance of any such covenants, conditions or provisions. Nothing contained in this Lease shall
limit or prejudice the right of the Landlord to prove for and obtain in proceedings for bankruptcy, insolvency or like proceedings by reason of the termination of this Lease, an amount equal to the maximum allowed by any statute or rule of law in
effect at the time when, and governing the proceedings in which, the damages are to be proved, whether or not the amount be greater, equal to, or less than the amount of the loss or damages referred to above. 
  

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 Section 9.4 Landlord’s Self-help. If there shall be an Event of Default, or if
emergency circumstances should exist where, upon the giving of notice or passage of time, such circumstances would constitute an Event of Default, then the Landlord shall have the right, but not the obligation, after the giving by the Landlord of
notice thereof to the Tenant (except in case of emergency circumstances in which case no prior notice need be given), to perform such obligation. In the event the Landlord exercises its rights under this Section 9.4 in case of emergency, the
Landlord shall notify the Tenant as soon as reasonably possible after the taking of such action. The Landlord may exercise its rights under this Section without waiving any other of its rights or releasing the Tenant from any of its obligations
under this Lease. The Tenant shall be liable to the Landlord for all of the Landlord’s reasonable costs associated with effecting such cure. 
 Section 9.5 Enforcement Expenses; Litigation: Each party hereto shall promptly reimburse the other for all costs and expenses, including without limitation legal fees, incurred by such party
in exercising and enforcing its rights under this Lease following the other party’s failure to comply with its obligations hereunder, whether or not such failure constitutes an Event of Default pursuant to Sections 9.1 or 9.7 hereof.

 If either party hereto be made or becomes a party to any litigation commenced by or against the other party by or against a
third party, or incurs costs or expenses related to such litigation, involving any part of the Property and the enforcement of any of the rights, obligations or remedies of such party, then the party becoming involved in any such litigation because
of a claim against such other party hereto shall receive from such other party hereto all costs and reasonable attorneys’ fees incurred by such party in such litigation. 
 Section 9.6 Late Charges; Interest on Overdue Payments. 
 (a) In the event that any payment of Annual Fixed Rent or Additional Rent shall remain unpaid for a period of ten
(10) days following notice by the Landlord to the Tenant that such payment is overdue, there shall become due to the Landlord from the Tenant, as Additional Rent and as compensation for the Landlord’s extra administrative costs in
investigating the circumstances of late rent, a late charge of two percent (2%) of the amount overdue. 
 (b) Any Annual Fixed Rent and Additional Rent or other amount which is due from either party to the other party which is not paid within ten (10) days after the same is due and payable shall bear interest from the date due until paid
at the variable rate (the “Default Interest Rate”) equal to the annual rate from time to time announced by Fleet Bank as its base rate, plus two percent (2%), or if such rate can no longer be determined, the annual prime rate from time to
time announced by The Wall Street Journal, plus two percent (2%). 
 Section 9.7 Landlord’s Right to Notice,
and Cure; Tenants Self-Help Rights. The Landlord shall in no event be in default in the performance of any of the Landlord’s obligations hereunder unless and until the Landlord shall have failed to perform such obligations within thirty
(30) days, or such additional time as is reasonably required to correct any such default, after written notice

  

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by the Tenant to the Landlord expressly specifying wherein the Landlord has failed to perform any such obligation. If the Landlord has failed to make any repair which results in a material risk
of damage or injury to persons or property within the Premises within thirty (30) days of such notice, or such additional time as is required (provided the Landlord shall have commenced to undertake such repair within thirty (30) days of
such notice and then diligently prosecutes such repair work) to make such repair, then the Tenant shall have the right, after providing an additional ten (10) days’ written notice to the Landlord, and any Mortgagee and Ground Lessor, to
perform such obligation so long as the same may be done solely on the Property. Notwithstanding the foregoing, in the case of an emergency, the Tenant shall have the right to perform any such obligation without regard to the thirty (30) day
notice period, so long as (a) the Tenant makes a good faith attempt to notify the Landlord prior to taking such action and (b) notifies the Landlord as soon as possible thereafter. The Landlord shall be liable to the Tenant for all of the
Tenant’s reasonable costs associated with effecting such cure, provided that in no event shall the Tenant be entitled to abate any Annual Fixed Rent or Additional Rent or otherwise offset such costs against sums due the Landlord under this
Lease. 
 ARTICLE 10 
 MORTGAGEES’ AND GROUND LESSORS’ RIGHTS 
 Section 10.1
Subordination. This Lease shall be subject and subordinate to any and all ground leases of the Property, and therefore the terms and conditions of any such ground lease shall be superior to all rights hereby or hereafter vested in the Tenant,
subject however to Section 10.5 hereof. There are no obligations imposed upon the Tenant under the ground lease except as expressly set forth in this Lease. At the election of the holder of any mortgage encumbering the Landlord’s interest
in the Property, which under this Lease means the Landlord’s leasehold interest under a ground lease, this Lease shall be subject and subordinate to the lien of any mortgages thereon, so that the rights of any such mortgagee shall be superior
to all rights hereby or hereafter vested in the Tenant, subject however to Section 10.5 hereof. 
 Section 10.2
Prepayment of Rent not to Bind Mortgagee or Ground Lessor. No Annual Fixed Rent, Additional Rent (other than estimated monthly payments on account of Additional Rent which the Tenant is required to pay pursuant to the provisions of this
Lease), or any other charge payable to the Landlord shall be paid more than thirty (30) days prior to the due date thereof under the terms of this Lease and payments made in violation of this provision shall (except to the extent that such
payments are actually received by a mortgagee or ground lessor) be a nullity as against such mortgagee or ground lessor and the Tenant shall be liable for the amount of such payments to such mortgagee or ground lessor. 
 Section 10.3 Tenant’s Duty to Notify Mortgagee and Ground Lessor; Mortgagee’s and Ground Lessor’s Ability to
Cure. The Tenant hereby agrees that, if the Tenant provides the Landlord with any notice of default or claimed default on the part of the Landlord under the Lease, the Tenant shall concurrently therewith send a copy of such notice to any
mortgagee and ground lessor of whom the Tenant has been given prior written notice (“Mortgagee” or “Ground Lessor” as applicable). In such event, the Mortgagee

  

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and Ground Lessor shall be permitted (but not obligated) to cure any such default. No act or failure to act on the part of the Landlord which would entitle the Tenant under the terms of this
Lease, or by law, to be relieved of the Tenant’s obligations to pay Annual Fixed Rent or Additional Rent hereunder or to terminate this Lease, shall result in a release or termination of such obligations of the Tenant or a termination of this
Lease unless (i) the Tenant shall have first given written notice of the Landlord’s act or failure to act to any Mortgagee and Ground Lessor, specifying the act or failure to act on the part of the Landlord which would give basis to the
Tenant’s rights; and (ii) no such Mortgagee or Ground Lessor, after receipt of such notice, shall have corrected or cured the condition complained of within a reasonable time thereafter (which shall include a reasonable period of time for
such mortgagee or ground lessors, not to exceed thirty (30) days after receipt of such notice, to obtain possession of the Property if possession is necessary for the mortgagee or ground lessor to correct or cure the condition and if the
mortgagee or ground lessor notifies the Tenant of its intention to take possession of the Property and correct or cure such condition). 
 Section 10.4 Estoppel Certificates. The Tenant shall from time to time, upon not less than fifteen (15) days’ prior written request by the Landlord, execute, acknowledge and deliver
to the Landlord a statement in writing certifying to the Landlord or an independent third party, with a true and correct copy of this Lease attached thereto, to the extent such statements continue to be true and accurate, (i) that this Lease is
unmodified and in full force and effect (or, if there have been any modifications, that the same is in full force and effect as modified and stating the modifications); (ii) that the Tenant has no knowledge of any defenses, offsets or
counterclaims against its obligations to pay the Annual Fixed Rent and Additional Rent and to perform its other covenants under this Lease (or if there are any defenses, offsets, or counterclaims, setting them forth in reasonable detail); (iii) that
there are no known uncured defaults of the Landlord or the Tenant under this Lease (or if there are known defaults, setting them forth in reasonable detail); (iv) the dates to which the Annual Fixed Rent, Additional Rent and other charges have
been paid; (v) that the Tenant has (if true) accepted, is satisfied with, and is in full possession of the Premises, including all improvements, additions and alterations thereto required to be made by Landlord under the Lease; (vi) that
(if true) the Landlord has satisfactorily complied with all of the requirements and conditions precedent to the occurrence of the Commencement Date with respect to the entire Building; (vii) that (if true) the Tenant has been in occupancy since
the Commencement Date and paying rent since the specified dates; (viii) that no monetary or other considerations, including, but not limited to, rental concessions for Landlord, special tenant improvements or Landlord’s assumption of prior
lease obligations of Tenant have been granted to Tenant by Landlord for entering into Lease, except as set forth in this Lease or as otherwise specified in such estoppel; (ix) that (if true) the Tenant has no notice of a prior assignment,
hypothecation, or pledge of rents or of the Lease; (x) that the Lease represents the entire agreement between Landlord and Tenant; (xi) that any notice to Tenant may be given it by certified or registered mail, return receipt requested, or
delivered, at the Premises, or at another address specified; and (xii) such factual other matters with respect to the Tenant and this Lease as the Landlord may reasonably request. On or following the Commencement Date, the Tenant shall, within
ten (10) days after receipt of Landlord’s request therefor, promptly execute, acknowledge and deliver to the Landlord a statement in writing that the Commencement Date has occurred, that the Annual Fixed Rent has begun to accrue with
respect thereto, and that the Tenant has taken occupancy of such portion of the Premises. Any statement delivered pursuant to this Section may be relied upon by any prospective purchaser, mortgagee or ground lessor of the Premises or any interest
therein, and shall be binding on the Tenant. 
  

 40 

 Landlord shall from time to time, upon not less than fifteen (15) days’ prior
written request by the Tenant, execute, acknowledge and deliver to the Tenant a statement in writing certifying to the Tenant or an independent third party, with a true and correct copy of this Lease attached thereto, to the extent such statements
continue to be true and accurate (i) that this Lease is unmodified and in full force and effect (or, if there have been any modifications, that the same is in full force and effect as modified and stating the modifications); (ii) that the
Landlord has no knowledge of any defenses, offsets or counterclaims against its obligations to perform its covenants under this Lease (or if there are any defenses, offsets, or counterclaims, setting them forth in reasonable detail); (iii) that
there are no known uncured defaults of the Tenant or the Landlord under this Lease (or if there are known defaults, setting them forth in reasonable detail); (iv) the dates to which the Annual Fixed Rent, Additional Rent and other charges have
been paid; (v) that the Tenant is in full possession of the Premises; (vi) that Landlord has no notice of a prior assignment of the Lease or sublease of space therein; (vii) that the Lease represents the entire agreement between
Landlord and Tenant; (viii) that any notice to Landlord may be given if by certified or registered mail, return receipt requested, or delivered to the Landlord’s address listed on Exhibit A or at another address specified; and
(xii) such other factual matters with respect to the Tenant and this Lease as the Tenant may reasonably request. Any statement delivered pursuant to this Section may be relied upon by any prospective assignee or sublessee of Tenant and shall be
binding on the Landlord. 
 Section 10.5 Subordination, Nondisturbance and Attornment Agreements. The subordination
of the Tenant’s rights under this Lease to ground lessors and mortgagees now existing or hereafter granted, as contemplated in Section 10.1, is subject to the condition that any such mortgagee or ground lessor shall have entered into a
subordination, nondisturbance and attornment agreement with the Tenant, the form of which shall be furnished by the mortgagee or ground lessor, as the case may be, with such reasonable modifications as Tenant shall request within a reasonable time
period. The form of non-disturbance and attornment agreement attached hereto as Exhibit G is acceptable to Tenant in connection with the Ground Lease held by MIT (as such terms are defined in Section 12.10). 
 ARTICLE 11 
 SECURITY DEPOSIT 
 Section 11.1 Tenant has paid to Landlord a security deposit (the “Lease Security
Deposit”). The Landlord may apply such Security Deposit, including all interest thereon accrued but not yet paid to the Tenant, as provided in this Article 11, upon any Event of Default by the Tenant hereunder. Provided there is no then
subsisting default by the Tenant under this Lease with respect to which the Landlord has given the Tenant notice, and thereafter only at such time as there is no such default by the Tenant then subsisting: (i) on each anniversary of the date
upon which the Commencement Date has occurred with respect to the entire Original Premises, all interest which shall have theretofore accrued on the Lease Security Deposit shall be disbursed to Tenant and (ii) within thirty (30)

  

 41 

 
days after the expiration of this Lease, any remaining portion of the Lease Security Deposit not theretofore applied shall be disbursed to Tenant. However, upon any termination of this Lease, the
Lease Security Deposit may first be applied by the Landlord to any amounts for which the Tenant is liable under this Lease. In the event the Landlord applies any funds constituting the Lease Security Deposit, the Tenant shall deliver to the Landlord
as Additional Rent, within ten (10) days after invoice therefor, the amount of the Lease Security Deposit applied by the Landlord, such that the balance of the Lease Security Deposit shall be restored to the appropriate amount specified herein.
Failure by the Tenant to timely make the Lease Security Deposit shall constitute a condition to the effectiveness of this Lease, failure of which to be timely satisfied by the Tenant shall entitle the Landlord to terminate this Lease. 
 Section 11.2 The Landlord may pledge its right and interest in and to such Lease Security Deposit to any mortgagee or ground lessor
and, in order to perfect such pledge, have such cash held in escrow by such mortgagee or ground lessee or grant such mortgagee or ground lessee a security interest therein. In connection with any such pledge or grant of security interest by the
Landlord to a mortgagee or ground lessee (“Security Deposit Pledgee”), Tenant covenants and agrees to cooperate as reasonably requested by the Landlord, in order to permit the Landlord to implement the same on terms and conditions
reasonably required by such mortgagee or ground lessee including, without limitation. Whether or not a Security Deposit Pledgee shall have a security interest therein, the Lease Security Deposit shall be deposited in a separately maintained and
accounted escrow account established with a bank or other financial institution reasonably acceptable to the Tenant (the “Escrow Holder”). The Tenant agrees that any Security Deposit Pledgee may be the Escrow Holder so long as the Security
Deposit Pledgee is a bank or other financial institution. The Landlord and the Tenant agree that a separate three-party escrow agreement, in form and substance satisfactory to the Landlord, the Tenant and the Escrow Holder, will be entered into
prior to the date upon which the Tenant may deposit any such sums in cash, and the Tenant agrees to reasonably cooperate from time to time as requested by the Landlord in order to effectuate the holding of any cash amount comprising a portion of the
Lease Security Deposit by the Escrow Holder in accordance with terms and conditions reasonably required by such Escrow Holder. Notwithstanding anything in this Lease to the contrary, the Lease Security Deposit shall at all times constitute the
property of the Tenant and title to the Security Deposits shall remain with the Tenant. To the extent, if any, the Security Deposits are deemed to be held by the Landlord they shall be deemed to be held in trust for the benefit of the Tenant, in all
cases, subject however to the Landlord’s rights pursuant to this Article 11. 
 ARTICLE 12 
 MISCELLANEOUS 
 Section 12.1 Notice of Lease. The Tenant agrees not to record this Lease, but upon request of either party, both parties shall execute and deliver a memorandum of this Lease in form appropriate for recording or registration, an
instrument acknowledging the Commencement Date of the Term, and if this Lease is terminated before the Term expires, an instrument in such form acknowledging the date of termination. 
  

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 Section 12.2 Notices. Whenever any notice, approval, consent, request, election,
offer or acceptance is given or made pursuant to this Lease, it shall be in writing. Communications and payments shall be addressed, if to the Landlord, at the Landlord’s Address for Notices as set forth in Exhibit A or at such other
address as may have been specified by prior notice to the Tenant; and if to the Tenant, at the Tenant’s Address or at such other place as may have been specified by prior notice to the Landlord. Any communication so addressed shall be deemed
duly given on the earlier of (i) the date received, or (ii) on the next business day if sent by a nationally recognized overnight courier service. If the Landlord by notice to the Tenant at any time designates some other person to receive
payments or notices, all payments or notices thereafter by the Tenant shall be paid or given to the agent designated until notice to the contrary is received by the Tenant from the Landlord. 
 Section 12.3 Successors and Limitation on Liability. The obligations of this Lease shall run with the land, and this Lease shall
be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns, except that the original Landlord named herein and each successor Landlord shall be liable only for obligations accruing during the period of
its ownership. Neither the Tenant, nor anyone claiming by, under or through the Tenant, shall be entitled to obtain any judgment in enforcing the terms and conditions of this Lease creating personal liability on the part of the Landlord or enforcing
any obligations of the Landlord against any assets of the Landlord other than its interest in the Property and, without limitation of the foregoing, in no event shall any personal liability arise on the part of any of the Landlord’s officers,
employees, directors or shareholders. Likewise, no personal liability shall arise on the part of the Tenant’s officers, employees, directors or shareholders, as this Lease shall create liability on the part of the Tenant and not personal
liability on the part of such officers, employees, directors or shareholders. 
 Section 12.4 Waivers. The failure
of the Landlord or the Tenant to seek redress for violation of, or to insist upon strict performance of, any covenant or condition of this Lease, shall not be deemed a waiver of such violation nor prevent a subsequent act, which would have
originally constituted a violation, from having all the force and effect of an original violation. The receipt by the Landlord of Annual Fixed Rent or Additional Rent with knowledge of the breach of any covenant of this Lease shall not be deemed a
waiver of such breach. No provision of this Lease shall be deemed to have been waived by the Landlord or the Tenant, as the case may be, unless such waiver be in writing signed by the Landlord or the Tenant, as the case may be. No consent or waiver,
express or implied, by the Landlord or Tenant to or of any breach of any agreement or duty shall be construed as a waiver or consent to or of any other breach of the same or any other agreement or duty. 
 Section 12.5 Acceptance of Partial Payments of Rent. No acceptance by either party of a lesser sum than the amount then due to
such party shall be deemed to be other than a partial installment of such rent due, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as rent be deemed an accord and satisfaction, and either party
may accept such check or payment without prejudice to the other party’s right to recover the balance of such installment or pursue any other remedy in this Lease provided. The delivery of keys to any employee of the Landlord or to the
Landlord’s agent or any employee thereof shall not operate as a termination of this Lease or a surrender of the Premises. 
  

 43 

 Section 12.6 Interpretation and Partial Invalidity. If any term of this Lease,
or the application thereof to any person or circumstances, shall to any extent be invalid or unenforceable, the remainder of this Lease, or the application of such term to persons or circumstances other than those as to which it is invalid or
unenforceable, shall not be affected thereby, and each term of this Lease shall be valid and enforceable to the fullest extent permitted by law. The titles of the Articles are for convenience only and not to be considered in construing this Lease.
This Lease contains all of the agreements of the parties with respect to the subject matter thereof and supersedes all prior dealings between them with respect to such subject matter. 
 Section 12.7 Quiet Enjoyment. So long as the Tenant pays Annual Fixed Rent and Additional Rent, performs all other Tenant
covenants of this Lease and observes all conditions hereof, the Tenant shall peaceably and quietly have, hold and enjoy the Premises free of any claims by, through or under, or superior title to, the Landlord including, without limitation, any
Ground Lessor or manager exercising rights under the Declaration of Covenants. 
 Section 12.8 Brokerage. Each party
represents and warrants to the other that it has had no dealings with any broker or agent other than Meredith & Grew, Incorporated (the “Broker”) in connection with this Lease and shall indemnify and hold harmless the other from
claims for any brokerage commission (other than by the Broker) arising out a breach of the foregoing representations. Landlord shall be responsible for any commission due to the Broker pursuant to the terms of a separate agreement. 
 Section 12.9 Surrender of Premises and Holding Over. The Tenant shall surrender possession of the Premises on the last day of
the Term and the Tenant waives the right to any notice of termination or notice to quit at the end of the Term. The Tenant covenants that upon the expiration or sooner termination of this Lease, it shall, without notice, deliver up and surrender
possession of the Premises in the same condition in which the Tenant has agreed to keep the same during the continuance of this Lease and in accordance with the terms hereof, normal wear and tear and damage by fire or other casualty excepted, first
removing therefrom all goods and effects of the Tenant and any leasehold improvements Landlord specified for removal pursuant to Section 4.2, and repairing all damage caused by such removal. Upon the expiration of this Lease or if the Premises
should be abandoned by the Tenant, or this Lease should terminate for any cause, and at the time of such expiration, vacation, abandonment or termination, the Tenant or Tenant’s agents, subtenants or any other person should leave any property
of any kind or character on or in the Premises after having vacated the Premises, the fact of such leaving of property on or in the Premises shall be conclusive evidence of intent by the Tenant, and individuals and entities deriving their rights
through the Tenant, to abandon such property so left in or upon the Premises, and such leaving shall constitute abandonment of the property. Landlord shall have the right and authority without notice to the Tenant or anyone else, to remove and
destroy, or to sell or authorize disposal of such property, or any part thereof, without being in any way liable to the Tenant therefor and the proceeds thereof shall belong to the Landlord as compensation for the removal and disposition of such
property. 
  

 44 

 If the Tenant fails to surrender possession of the Premises upon the expiration or sooner
termination of this Lease, the Tenant shall pay to Landlord, as rent for any period after the expiration or sooner termination of this Lease an amount equal to one hundred fifty percent (150%) of the Annual Fixed Rent and the Additional Rent
required to be paid under this Lease as applied to any period in which the Tenant shall remain in possession. Acceptance by the Landlord of such payments shall not constitute a consent to a holdover hereunder or result in a renewal or extension of
the Tenant’s rights of occupancy. Such payments shall be in addition to and shall not affect or limit the Landlord’s right of re-entry, Landlord’s right to collect such damages as may be available at law, or any other rights of the
Landlord under this Lease or as provided by law. 
 Section 12.10 Ground Lease. The Land is owned by the
Massachusetts institute of Technology (“MIT”). MIT as lessor and the Landlord as lessee (or a limited partnership of which the Landlord would be the general partner (the “Limited Partnership”) and to whom all of the
Landlord’s rights and obligations under this Lease may be assigned in the Landlord’s sole discretion) shall enter into a ground lease (the “Ground Lease”) of the Land, and this Lease shall in all respects be subject to such
Ground Lease. If the Ground Lease shall terminate during the Term for any reason whatsoever, except as may otherwise be agreed between MIT and the Tenant, this Lease shall terminate with the same force and effect as if such termination date had been
named herein as the date of expiration hereof. However, this Lease is subject to the execution by MIT, the Tenant and the Landlord of a non-disturbance agreement in the form attached hereto as Exhibit G. Each party shall pay its own expenses
related to such non-disturbance agreement. The Landlord represents and warrants to the Tenant that, upon execution of the Ground Lease by the Landlord, or upon assignment of this Lease to the Limited Partnership and the execution of the Ground Lease
by the Limited Partnership, the Landlord or the Limited Partnership, as the case may be, shall have the full right and authority to grant the estate demised herein and the appurtenant rights granted herein. 
 Section 12.11 Financial Reporting. Tenant shall from time to time (but not less frequently than quarterly) provide Landlord with
financial statements of Tenant, together with related statements of Tenant’s operations for Tenant’s most recent fiscal year then ended, certified by an independent certified public accounting firm. Notwithstanding the foregoing, so long
as the Tenant is a public company, it shall be in compliance with its financial reporting obligations provided that it submits, upon request by the Landlord, all 10-Q and 10-K reports to the Landlord within ten (10) business days of filing the
same with the Securities and Exchange Commission. 
 Section 12.12 Cambridge Employment Plan. The Tenant agrees to
sign an agreement with the Employment and Training Agency designated by the City Manager of the City of Cambridge as provided in subsections (a)-(g) of Section 24-4 of Ordinance Number 1005 of the City of Cambridge, adopted April 23,
1984. 
 Section 12.13 Truck Delivery Routes; Traffic Mitigation Measures. Tenant agrees to exercise good faith
efforts to cooperate with any efforts by the City of Cambridge to direct truck traffic to certain streets and away from certain other streets, in connection with the making of deliveries to the Premises, and to comply with any traffic mitigation
measures of the City of Cambridge applicable to the Building, and Tenant shall otherwise comply with all legal requirements of the City of Cambridge pertaining thereto. 
  

 45 

 Section 12.14 Parking and Transportation Demand Management. Tenant covenants and
agrees to work cooperatively with Landlord to develop a parking and transportation demand management (“PTDM”) program that comprises part of a comprehensive PTDM for University Park. In connection therewith, the use of single occupant
vehicle commuting will be discouraged and the use of alternative modes of transportation and/or alternative work hours will be promoted. Without limitation of the foregoing, Tenant agrees that its PTDM program (and Tenant will require in any
sublease or occupancy agreement permitting occupancy in the Premises that such occupant’s PTDM program) will include offering a subsidized MBTA transit pass, either constituting a full subsidy or a subsidy in an amount equal to the maximum
deductible amount therefor allowed under the federal tax code, to any employee working in the Premises requesting one. The Tenant agrees additionally to comply with any other requirements of the City of Cambridge or other governmental authorities
associated with parking or transportation management that are now in effect or hereafter adopted. 
 Section 12.15
Laboratory Animals. The Landlord acknowledges that the Tenant will be conducting biotechnology research and development at the Premises and as such may require the use of certain laboratory animals at the Premises in order to carry out such
research and development. 
 Section 12.16 No Consequential Damages. In no event shall either Landlord or Tenant be
liable to the other for consequential damages, provided that damages incurred by the Landlord in connection with any holding over by Tenant in the Premises, including without limitation those associated with loss, cost, liability or expense arising
by virtue of the existence of aggrieved third parties (e.g. lenders and prospective tenants), shall not constitute consequential damages. 
 Section 12.17 Governing Law. This Lease shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 
 (The remainder of this page is intentionally left blank) 
  

 46 

 IN WITNESS WHEREOF, this Lease has been executed and delivered as of the date first above
written as a sealed instrument. 
  

			
	LANDLORD:
	
	FOREST CITY 64 SIDNEY STREET, INC.
		
	By:	 	/s/ Gayle B. Farris
		 	Gayle B. Farris
		 	Vice President
	
	TENANT:
	
	ALKERMES, INC.
		
	By:	 	/s/ Illegible
	Title:	 	Vice President

  

 47 

 EXHIBIT A 
 Basic Lease Terms 
  

			
	Annual Fixed Rent
for the Initial Term:	  	  
 •     With respect to the Rentable Floor Area of the 5th Floor:
  
 (i)              per rentable square foot for the period from the
Commencement Date until April 30, 2007 (provided that if there is a Stub Period, then this date shall be extended for a period equal to the number of days of the Stub Period) and (ii)
             per rentable square foot for the remainder of the Initial Term.

		
		  	 •     With respect to the Rentable Floor Area of the 4th
Floor:
  
 (i)
             per rentable square foot for the period from the Commencement Date until March 31, 2002, (ii)              per
rentable square foot for the period from April 1, 2002 until April 30, 2007 (provided that if there is a Stub Period, then this date shall be extended for a period equal to the number of days of the Stub Period) and (iii)
             per rentable square foot for the remainder of the Initial Term.

		
		  	 •     With respect to the Rentable Floor Area of Suite 300:

  
 (i)
             per rentable square foot for the period from the Commencement Date until the later of (x) March 31, 2002 or (y) the date thirty (30) days following the 88 Sidney Rent
Commencement Date, (ii) if an 88 Sidney Non-fruition Termination should occur, then              per rentable square foot for the period from the later of (x) April 1, 2002 or (y) the date
of such 88 Sidney Non-fruition Termination until April 30, 2007, and (iii)              per rentable square foot for the remainder of the Initial Term. Notwithstanding the foregoing, if the
Tenant should hold over in this space in contravention of the Tenant’s obligation to surrender the same under Section 2.1(b) hereof, then the rate of Annual Fixed Rent thereafter applicable thereto, including without limitation for purposes of
the calculation of holdover payments under Section 12.9, shall equal              per rentable square foot.

		
		  	 •     With respect to the Rentable Floor Area of Suite 180:

  
 (i)
             per rentable square foot for the period from the Commencement Date until the later of (x) March 31, 2002 or (y) the date thirty (30) days following the 88 Sidney Rent
Commencement Date, (ii) if an 88 Sidney Non-fruition Termination should occur, then              per rentable square foot for

  

 A-1 

			
		  	the period from the later of (x) April 1, 2002 or (y) the date of such 88 Sidney Non-fruition Termination until April 30, 2007, and
(iii)         per rentable square foot for the remainder of the Initial Term. Notwithstanding the foregoing, if the Tenant should hold over in this space in contravention of the Tenant’s obligation to
surrender the same under Section 2.1(b) hereof, then the rate of Annual Fixed Rent thereafter applicable thereto, including without limitation for purposes of the calculation of holdover payments under Section 12.9, shall
equal         per rentable square foot.
		
	Initial Term:	  	Approximately eleven (11) years and six (6) months (subject to the provisions of Section 2.1), commencing on the Commencement Date, and expiring on April 30, 2012 or such
later date upon which the Stub Period expires, if applicable (“Termination Date”).
		
	Extension Options:	  	Tenant shall have options to extend the Initial Term of this Lease for two (2) additional periods of ten (10) years each, all as described in Section 2.6 of the
Lease;
		
	Landlord’s Original	  	
	Address:	  	Forest City 64 Sidney Street, Inc.
		  	1130 Terminal Tower
		  	50 Public Square
		  	Cleveland, Ohio 44113-2203
		  	Attention: James Ratner
		
	Landlord’s Address for	  	
	Notices:	  	Forest City 64 Sidney Street, Inc.
		  	38 Sidney Street
		  	Cambridge, Massachusetts 02139-4234
		  	Attention: Gayle B. Farris
		
		  	With a copy to:
		
		  	 Forest City Commercial Management
 38 Sidney Street

		  	 Cambridge, Massachusetts 02139-4234
 Attention: General Manager

		
	Premises:	  	Approximately 64,973 rentable square feet (“rsf”), consisting of all of the rentable area of floors 4 and 5 of the Building (and including the acid neutralization room
on the first floor of the Building) and Suite 300 on the third floor of the Building and Suite 180 on the first floor of the Building.

  

 A-2 

			
	Parking Privileges:	  	During the Term, Landlord shall cause to be provided to Tenant 1.5 parking passes per 1,000 rentable square feet of the Premises, provided that the Landlord shall not provide
fractional parking passes (each a “Parking Pass”), each of which shall entitle the parking of a single motor vehicle in an unreserved parking space in University Park, the charges for which shall equal the Market Rate Parking Charge per
Parking Pass. Such parking spaces shall be accessible twenty four (24) hours per day, seven (7) days per week. In no event are Parking Passes transferable other than to the holder, from time to time, of the tenant’s interest under this Lease or
a subtenant that has been demised all or a portion of the Premises in conformity with the requirements of this Lease, and is limited to use by employees of either of the foregoing. If the Tenant requests additional Parking Passes, and at the time in
question there are surplus Parking Passes that are not committed to others, then they may be made available by the Landlord, on a month-to-month basis, subject to availability.
		
	Permitted Uses:	  	General business and administrative offices, research and development and customary accessory uses supporting the foregoing, all as defined by and as permitted under the Zoning
Ordinances of the City of Cambridge.
		
	Commencement Date:	  	See Section 2.5.
		
	Commencement Date:	  	See Section 2.5.
		
	Tenant’s Address:	  	Alkermes, Inc.
		  	 64 Sidney Street
 Cambridge,
MA 02139-4211
 Attention: James M. Frates,
 Chief Financial Officer

		
		  	With copies to:
		
		  	 Ballard Spahr Andrews & Ingersoll, LLP
 1735 Market Street, 51st Floor
 Philadelphia, PA 19103-7599
 Attention: Michael D. Silbert, Esq.

  

 A-3 

 EXHIBIT B  
 Legal Description 
  

 B-1 

 64 Sidney Street 
 A parcel of land situated in the City of Cambridge, Middlesex County, Commonwealth of Massachusetts, being more particularly bounded and described as Follows: 
 Beginning at the intersection of the relocated southeasterly street line of Sidney Street and the southwesterly street line of a private way (Formerly
Auburn Street) 
 Thence running S 51° 25’ 00” E along said southwesterly line of a private way, a distance of 131.51 feet, to a
point; 
 Thence running along the line of a private way on the following three (3) courses: 
 S 38° 25’ 13” W, a distance of 176.99 feet to a point; 
 Westerly on a curve to the left having a radius of 60.00 feet, an arc length of 62.88 feet to a point; 
 and N 51°34’ 47” W, a distance of 91.97 feet to a point on the aforesaid relocated southeasterly street line of Sidney Street; 
 Thence running N 380 25’ 13” E, along said southeasterly line, a distance of 17.52 feet, to a point; 
 Thence running S 51° 34’
47” E, along a jog in said southeasterly line, a distance of 4.00 feet, to a point; 
 Thence running N 38° 25’ 13” E, along
said southeasterly line, a distance of 201.18 feet, to the point of beginning. 
 The above described parcel contains 27,580 square feet, more
or less, or 0.6332 acres, more or less. 
 A portion of said parcel is registered land under Land Court Case Nos. 7631 and 3993. 

 EXHIBIT B-1  
 Depiction of Premises 
  

 B-1-1 

 EXHIBIT B-1 
 

 
  

 EXHIBIT B-1 
 

 

 EXHIBIT B-1 
 

 
  

 EXHIBIT B-1 
 

 
  

 EXHIBIT B-1 
 

 
  

 EXHIBIT B-2  
 Map of University Park 
  

 B-2-1 

 

 
  

 EXHIBIT C 
 Work Letter 
 1. Landlord shall provide to
Tenant an allowance (the “Leasehold Improvements Allowance”) equal to (i) the product of Five and 00/100 Dollars ($5.00) times (ii) the rentable square footage of the Premises (as determined in accordance with paragraph 2 below),
for application to certain costs and expenses, more particularly set forth below, incurred by or on behalf of Tenant. If Tenant incurs costs in excess of the Leasehold Improvements Allowance, then all such costs shall be borne solely by Tenant.

 2. For purposes of calculating the rentable floor area of the Premises under this Work Letter, the square footage
calculations specified for portions of the Building set forth in Section 1.2 shall govern. For purposes of determining the space within the Building that shall be included in the Premises for purposes of calculating the Leasehold Improvements
Allowance, the Premises shall be deemed to be established upon the occurrence of the 88 Sidney Rent Commencement Date, or such earlier date upon which Tenant’s right to cause an 88 Sidney Non-fruition Termination has either expired because all
of the conditions to such right cannot any longer occur (and Tenant confirms this is the case in writing), or Tenant earlier waives in writing any right to cause an 88 Sidney Non-fruition Termination. In such event, the Premises shall be deemed
constituted of the rentable area of the fourth and fifth floors of the Building and will exclude the Surrender Space. However, in the event of an 88 Sidney Non-fruition Termination, then the Premises for purposes of calculating the Leasehold
Improvements Allowance shall be established only upon the expiration of the period within which Tenant may either terminate this Lease in its entirety, or just with respect to the Surrender Space or a portion thereof as contemplated under
Section 2.1(c), or Tenant’s earlier written waiver of any such right to terminate this Lease. The Premises shall, in such event, be deemed constituted of only such space as Tenant will be leasing for a term expiring upon the originally
scheduled Termination Date of this Lease. If Tenant terminates this Lease under said Section 2.1(c), there shall not be any Leasehold Improvements Allowance hereunder, notwithstanding anything to the contrary provided in this Lease. Only upon
the determination of the space within the Building to be included in the Premises for purposes of calculating the Leasehold Improvements Allowance, as herein set forth, may Tenant draw all or any portion of the Leasehold Improvements Allowance.

 3. The application of the Leasehold Improvement Allowance by Landlord shall be limited to payment of the following costs and
expenses incurred by or on behalf of Tenant in connection with leasehold improvements to the Premises that constitute the Base Laboratory Improvements (collectively “Eligible Leasehold Improvement Expenses”): the actual documented and
verified cost pursuant to Tenant’s construction contract, including without limitation the associated contractor’s overhead and profit and general conditions incurred in the construction of the leasehold improvements to the Premises,
except for the making of improvements, installation of fixtures or incorporation of other items which (x) by virtue of their quantity or quality (whether greater or less) would not be of general utility to other laboratory tenants that might
later occupy the Premises, whether at the expiration of the Term or by virtue of the earlier termination of this Lease, or (y) are moveable rather than permanent improvements, examples of which may include furniture, telephone communications
and security equipment, and bench-top laboratory equipment items such as microscopes. 
  

 C-1 

 During the construction of any leasehold improvements with respect to which Tenant desires
to have the Leasehold Improvement Allowance applied, and in accordance with the commercially reasonable terms and conditions typically imposed upon a landlord pursuant to a construction loan agreement, such as, without limitation, retainage, lien
waiver, and other requisition conditions, Tenant shall, on a monthly basis (as the Tenant’s contractor submits to Tenant its application for payment), deliver to Landlord a requisition for payment showing the cost of the leasehold improvements
in question and the amount of the current payment requested from Landlord for disbursement from the Leasehold Improvements Allowance. Payments made on account of Tenant’s requisitions shall be made from the Leasehold Improvement Allowance.
Following the completion of any such leasehold improvements, Tenant shall deliver to the Landlord, within ninety (90) days of completion, a statement showing the final costs of such leasehold improvements, the amounts paid to date to, or on
behalf of the Tenant, and any amounts available for release of retainage. 
 4. Any improper failure by Landlord to make payment
of all or any portion of the Leasehold Improvements Allowance shall constitute a default by Landlord under this Work Letter and consequently under the Lease, and shall therefor be governed in accordance with Section 9.7. However, after the
expiration of the notice and cure periods set forth in Section 9.7 of the Lease, and subject in any case to the proviso set forth in the last sentence of said Section 9.7, Tenant shall have the right to offset such payments owing to Tenant
against sums otherwise due and owing by Tenant to Landlord under the Lease. 
  

 C-2 

 EXHIBIT D 
 Standard Services 
 The following services will be provided
exclusively by the Landlord: 
  

	A.	Regular maintenance of exterior and parking lot landscaping and University Park common areas. 

  

	B.	Regular maintenance, sweeping and snow removal of building exterior areas such as roadways, driveways, sidewalks, parking areas and courtyard paving.

  

	C.	Maintenance and repair of base building surveillance and alarm equipment, base building elevators, base building mechanical, electrical and plumbing systems, and base
building life safety systems. 

  

	D.	Building surveillance and alarm system operation and the Landlord’s live monitoring service to building standard specifications. 

  

	E.	Complete interior and exterior cleaning of all windows two times per year. 

  

	F.	Daily, weekday maintenance of hallways, passenger elevators, bathrooms, lobby areas and vestibules. 

  

	G.	Periodic cleaning of stairwells, freight elevators, and back of house areas. 

  

	H.	Daily, weekday rubbish-removal of all tenant trash receptacles. 

  

	I.	Daily, weekday cleaning of Tenant space to building standard. 

  

	J.	Surveillance personnel having a desk in the building lobby. 

  

 D-1 

 EXHIBIT E  
 Rules and Regulations 
 DEFINITIONS 
 Wherever in these Rules and Regulations the word “Tenant” is used, it shall be taken to apply to and include the Tenant and its
agents, employees, invitees, licensees, contractors, any subtenants and is to be deemed of such number and gender as the circumstances require. The word “Premises” is to be taken to include the space covered by the Lease. The word
“Landlord” shall be taken to include the employees and agents of Landlord. Other capitalized terms used but not defined herein shall have the meanings set forth in the Lease. 
 The following Rules and Regulations apply to buildings that are wholly occupied by a single tenant. 
  

	 	A.	No actions shall be taken by Tenant that modify the exterior appearance of the Premises or the Building, unless expressly permitted by the Lease or the Landlord.

  

	 	B.	No blinds, shades, awnings or other window treatments shall be placed or installed in windows or curtain wall glazing other than those approved and installed as
Building Standard. 

  

	 	C.	No sign, advertisement, notice or the like, shall be posted on the Building exterior, in windows visible from the exterior of the building, or in the building lobby
except as permitted under the terms of the Lease or as reasonable necessary in the operation of Tenant’s business without prior approval of Landlord, not to be unreasonably withheld. 

  

	 	D.	The Building lobby shall be open to the public during normal business hours (at a minimum 9:00 a.m. through 5:00 p.m., Monday through Friday except legal holidays).
Tenant shall be responsible for locking of doors to the Premises. All locksets shall accept the Best key system. If the Building key system is maintained by Tenant, designated representatives of Landlord shall be provided with keys and/or access
cards so as to facilitate access to all spaces within the Building in case of emergency. No locks or similar devices not on the master key system shall be attached to any doors. 

  

	 	E.	All deliveries to the Building, other than envelopes and small packages that can legitimately be delivered by hand or bicycle courier service, shall be accepted only
through the building loading dock and not through the main lobby. 

  

	 	F.	Bicycles may only be stored in designated bicycle racks provided in University Park garages or elsewhere on the grounds of University Park. Bicycles shall not be
fastened to fences, signposts, or other non-designated equipment, nor shall bicycles or vehicles of any kind shall be brought into or kept in or about the building lobby or the Premises. 

  

 E-1 

	 	G.	Tenant shall not cause or permit any unusual or objectionable odors, noises or vibrations to emanate from said Premises. 

  

	 	H.	No pets or other animals, excepting those used for research purposes or by a disabled person, shall be permitted in or about the Building or the grounds of the Park.

  

	 	I.	Unless specifically authorized by Landlord, employees or agents of Landlord shall not perform for nor be asked by Tenant to perform work other than their regularly
assigned duties. 

  

	 	J.	Canvassing, soliciting and peddling in the Building is prohibited and Tenant shall cooperate to prevent the same from occurring. 

  

	 	K.	Access roads and loading areas, parking areas, sidewalks, entrances, lobbies, halls, walkways, elevators, stairways and other common area provided by Landlord shall not
be obstructed by Tenant, or used for other purpose than for ingress and egress. 

  

	 	L.	Landlord shall have the right to make such other and further reasonable rules and regulations as in the judgment of Landlord, may from time to time be needed for the
safety, appearance, care and cleanliness of the Building or the park and for the preservation of good order therein. All reasonable parking, building operation, or construction rules and regulations which may be established from time to time by
Landlord and enforced on a uniform basis (i.e. non-discriminatory) shall be respected and obeyed, subject to the requirements of this Lease. 

  

	 	M.	Landlord shall not be responsible to Tenant for any violation of rules and regulations by other tenants except that Landlord shall use good faith efforts to uniformly
enforce such rules and regulations. 

  

 E-2 

 EXHIBIT F 
 Intentionally Omitted 
  

 F-1 

 EXHIBIT G 
 Form of MIT Non-Disturbance Agreement 
 Agreement dated as of March         , 2000 (this “Agreement”), by and between MASSACHUSETTS INSTITUTE OF TECHNOLOGY, a Massachusetts educational corporation chartered by Massachusetts
law (the “Ground Lessor”), FC 88 SIDNEY, INC., a Massachusetts corporation (“Landlord”) and ALKERMES, INC., a Pennsylvania corporation (‘Tenant”). 
 BACKGROUND 
 Ground Lessor and Landlord are parties,
as landlord and tenant respectively, to a Construction and Lease Agreement (“Ground Lease”) dated                     , 2000, for
certain real property located at 88 Sidney Street in Cambridge, Massachusetts, as more particularly described on Exhibit A attached hereto (“Land”). A Notice of Lease pertaining to the Ground Lease has been recorded at the Middlesex
South District Registry of Deeds and filed for registration in the Middlesex South Registry District of the Land Court. Landlord intends to construct a building (the “Building”) on the Land. Tenant has entered into a lease dated as of
                    , 2000 (“Lease”) with Landlord for certain premises in the Building (“Premises”), the Premises being
more particularly described in the Lease. 
 AGREEMENTS 
 1. Non-Disturbance. If the Ground Lease is terminated, for any reason, Ground Lessor shall not disturb Tenant in Tenant’s
possession of the Premises and without any hindrance or interference from the Ground Lessor, shall permit Tenant peaceably to hold and enjoy the Premises for the remainder of the unexpired term of the Lease, together with any extension periods
provided for therein, upon and subject to the same terms, covenants and conditions as are contained in the Lease, and shall recognize the Lease as modified hereby. The foregoing is on the condition that Tenant is not in default under the Lease
beyond any applicable notice and grace periods contained in the Lease. 
 2. Attornment. Tenant hereby agrees that if the
Ground Lease is terminated for any reason, Tenant shall attorn to Ground Lessor and shall be liable to and recognize Ground Lessor as Landlord under the Lease for the balance of the term of the Lease upon and subject to all of the terms and
conditions thereof. In such case, upon receipt of notice from Ground Lessor setting forth the effective date of the termination of the Ground Lease, Tenant shall pay to the Ground Lessor all obligations required to be paid and performed by Tenant
under the Lease arising after the date of termination. The Lease shall continue in full force and effect as a direct lease between Ground Lessor and Tenant. 
 3. Additional Conditions. Tenant agrees that Ground Lessor shall not be: (i) liable for any act or omission of any person or party who may be landlord under the Lease prior to any termination
of the Ground Lease (“Prior Landlord”); (ii) subject to any offsets or defenses which Tenant might have against Prior Landlord; (iii) bound by any prepayment of rent or additional rent, or any other

  

 G-1 

 
charge which Tenant might have paid to Prior Landlord for more than the then current month (other than a bona fide security deposit paid by Tenant to Landlord under the Lease, estimated monthly
payments made on account of additional rent as and when required to be made pursuant to the provisions of the Lease, or other rent, additional rent or charges which have been received by Ground Lessor); and (iv) bound by any amendment,
modification or termination of the Lease made without Ground Lessor’s express agreement when such agreement is required under the Ground Lease. Tenant additionally agrees with Ground Lessor that Tenant shall not enter into any assignment of the
Lease or sublease of all or any part of the Premises in cases where Landlord’s consent is required thereto, unless Ground Lessor shall have also given its consent thereto, which consent shall not be unreasonably withheld or delayed. Nothing
herein, however, shall constitute a waiver of Tenant’s rights as against such individual or entity which is the landlord under the Lease as of the time of any event or circumstances which may give rise to a claim of the Tenant against such
individual or entity. In addition, nothing herein shall relieve any successor landlord under the Lease from its obligation to comply with those obligations of a Landlord under the Lease during the period for which it is the owner of the
Landlord’s interest in the Lease. 
 4. Landlord’s Defaults. Tenant hereby agrees that, if Tenant provides
Landlord with any notice of default or claimed default on the part of Landlord under the Lease, Tenant shall concurrently therewith send a copy of such notice to Ground Lessor. In such event, Ground Lessor shall be permitted (but not obligated) to
cure any such default within the period of time allotted thereto in the Lease. If Landlord shall fail to cure such default within the period of time allocated thereto in the Lease (or, if Landlord shall not within such time period have commenced
diligent efforts to remedy a default that cannot be fully cured within such time period) then Tenant shall provide Ground Lessor with notice of such failure. Upon receipt of such notice of Landlord’s failure to cure, Ground Lessor shall be
granted an additional thirty (30) days during which it shall be permitted (but not obligated) to cure such default. In the case of a default, which cannot with diligence be remedied by Ground Lessor within thirty (30) days, Ground Lessor
shall have such additional period of time as may be reasonably necessary in order for Ground Lessor to remedy such default with diligence and continuity of effort, provided that Ground Lessor has commenced to cure such default within such thirty
(30) day period. 
 5. Notices. Duplicates of all notices delivered by any party to another party and required by
this Agreement shall be delivered concurrently to all other parties to this Agreement. All notices shall be written, delivered by certified or registered mail, and sent, if to Ground Lessor, to 238 Main Street, Suite 200, Cambridge, Massachusetts
02142, Attention: Director of Real Estate, if to Tenant to 64 Sidney Street, Cambridge, Massachusetts 02139-4211, Attention: James M. Frates, Chief Financial Officer, before the commencement of Tenant’s occupancy in the Premises, and to the
Premises after the Commencement Date shall have occurred with respect to the entire Original Premises, and if to Landlord to 38 Sidney Street, Cambridge, MA 02139-4234, Attention: Ms. Gayle B. Farris, or such addresses as may, from time to
time, be set forth in notices to the other parties hereunder. 
 6. Exculpation of Ground Lessor. Ground Lessor shall not
be personally liable hereunder. Tenant agrees to look to Ground Lessor’s interest in the Land and Building only for satisfaction of any claim against Ground Lessor hereunder. 
  

 G-2 

 7. Successors and Assigns. This Agreement shall bind Tenant, its successors and
assigns, and shall benefit Tenant and only such successor and assigns of Tenant as are permitted by the Lease and shall bind and benefit Ground Lessor and its successors and assigns (provided that after transfer of Ground Lessor’s entire
interest in the Land to another party, Ground Lessor shall have no liability for any act or omission of such party) and shall bind and benefit Landlord and its successors and assigns. 
 EXECUTED as an instrument under seal as of the date set forth above. 
  

			
	MASSACHUSETTS INSTITUTE OF TECHNOLOGY
	Ground Lessor
		
	By: 	 	 
		 	
	
	ALKERMES, INC.
	Tenant
		
	By:	 	 
		 	
	
	FOREST CITY 64 SIDNEY, INC.
	Landlord
		
	By:	 	 
		 	

  

 G-3 

					
	COMMONWEALTH OF MASSACHUSETTS	  	)	  	
		  	)	  	ss:
	COUNTY OF MIDDLESEX	  	)	  	

 BEFORE ME, a Notary Public in and for said County and State, personally appeared the
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, by             , its Director of Real Estate and Associate Treasurer, who acknowledged that he did sign the foregoing instrument and that the
same is his free act and deed and the free act and deed of said corporation. 
 IN TESTIMONY HEREOF, I set my hand and official
seal at                 , this          day of
            ,         . 
  

	
	  
	Notary Public
	My Commission Expires:
                                        

  

					
	COMMONWEALTH OF MASSACHUSETTS	  	)	  	
		  	)	  	ss:
	COUNTY OF MIDDLESEX	  	)	  	

 BEFORE ME, a Notary Public in and for said County and State, personally appeared the
above-named ALKERMES, INC., by              who acknowledged that he/she did sign the foregoing instrument and that the same is his/her free act and deed and the free act and deed of
said corporation. 
 IN TESTIMONY HEREOF, I set my hand and official seal at
                , this          day of
            ,         . 
  

	
	  
	Notary Public
	My Commission Expires:
                                        

  

 G-4 

					
	 COMMONWEALTH OF MASSACHUSETTS
	  	)	  	
		  	)	  	ss:
	 COUNTY OF MIDDLESEX
	  	)	  	

 BEFORE ME, a Notary Public in and for said County and State, personally appeared the
above-named FC 88 SIDNEY, INC., by                  who acknowledged that he/she did sign the foregoing instrument and that the same is his/her free act and deed
and the free act and deed of said corporation. 
 IN TESTIMONY HEREOF, I set my hand and official seal at
                , this          day of
            ,         . 
  

	
	  
	Notary Public
	My Commission Expires:
                                        

  

 G-5 

 EXHIBIT H  
 Intentionally Omitted 
  

 H-1 

 EXHIBIT I 
 Expedited Dispute Resolution Procedure 
 Any
dispute or determination by a party hereto which, pursuant to the terms of this Lease, may be resolved by the “Expedited Dispute Resolution Procedure,” shall be undertaken in accordance with the following provisions: 
 (a) In the event of any such dispute, the complaining party (the “Claimant”) shall serve upon the other party (the
“Respondent”) by registered mail or hand delivery a written demand for arbitration (the “Dispute Notice”), setting forth with particularity the nature of the dispute. The Claimant shall simultaneously serve any request (the
“Document Request”) for production of relevant documents from the Respondent. The service of such Dispute Notice and Document Request shall be effective upon receipt thereof. Failure to serve a Document Request shall constitute a waiver by
the Claimant of any right to demand documents from the Respondent, except as provided in Subparagraph (c) below. The Dispute Notice shall also be delivered to J.A.M.S./Endispute, 73 Tremont Street, 4th floor, Boston, Massachusetts 02108, for
mediation as part of that firm’s national mediation services expertise. J.A.M.S./Endispute shall select a member of the company to conduct the arbitration (hereinafter the “Arbitrator”), the choice of which shall be binding on the
parties. If J.A.M.S./Endispute believes it has a material conflict of interest with any of the parties, it shall select an alternative nationally recognized firm to conduct the arbitration, within ten (10) business days of receipt of the
Dispute Notice. If J.A.M.S./Endispute shall cease to exist and/or shall decline to serve under this Lease as to all or any particular dispute submitted thereto for arbitration, and within ten (10) business days of receipt of a Dispute Notice,
shall fail to select an alternative nationally recognized firm, then, and in any such event, the parties shall mutually select an alternative arbitrator for their dispute(s) and, in the absence of agreement within a period often (10) days,
either party shall have the right, on notice to the other, to apply to the President of the Boston Bar Association for selection of an independent arbitrator. 
 (b) Response by Respondent. Within ten (10) business days of receipt of a Dispute Notice and Document Request, the Respondent shall serve a detailed written response to the Dispute Notice,
including any arbitrable counterclaims, and shall produce all non-privileged documents called for in the Document Request. At the same time, Respondent shall serve any Document Request on Claimant, failing which Respondent shall be deemed to have
waived any right to demand documents from Claimant. Within two (2) business days of delivery of the response, all undisputed amounts shall be paid by Respondent by wire transfer. 
 (c) Response by Claimant. Within ten (10) business days of receipt of such written response, the Claimant shall serve a reply to
any counterclaims asserted by Respondent and shall produce all non-privileged documents requested by Respondent. At the same time, the Claimant may serve a second Document Request limited to documents relevant to Respondent’s counterclaim.
Within two (2) business days of delivery of the reply to any counterclaims, all undisputed amounts shall be paid by the Claimant by wire transfer. 
  

 I-1 

 (d) Response by Respondent. Respondent shall produce all non-privileged documents
called for in any such second Document Request within ten (10) business days of service thereof. 
 (e) Appearance Before
Arbitrator. Within thirty-five (35) business days of service of the Dispute Notice, any arbitrable dispute shall be submitted to the Arbitrator, whose decision shall be final, binding and non-appealable, and may be entered and enforced as a
judgment by any court of competent jurisdiction. The Arbitrator shall consider and determine only matters properly subject to arbitration pursuant to this Lease. 
 The Arbitrator shall, in consultation with the parties, establish such further procedures, including hearings, as he or she deems appropriate, provided, however, that a decision of the dispute (including
counterclaims) shall be rendered no later than sixty (60) business days after service of the Dispute Notice. 
 (f) Final
Decision; Fees and Expenses. The Arbitrator’s decision shall be in writing, and shall include findings of fact and a concise explanation of the reasons for the decision. The decision shall be delivered to the parties immediately. The
Arbitrator’s fees and expenses shall be borne by one or both of the parties in accordance with the direction of the Arbitrator, who shall be guided in such determination by the results of the arbitration. If any party refuses to appear before
the Arbitrator or to respond as required in subparagraphs (a) through (e) above, the Arbitrator shall decide the matter as by default against the non-appearing party, and such decision shall be final, binding and non-appealable to the same
extent as a decision rendered with the full participation of such party. 
  

 I-2 

 EXHIBIT B  
 Plan of Subleased Premises 
 (see attached)

  

 21Exclusive License Agreement, Dana-Farber Cancer Institute, Inc.

 Exhibit 10.21 
 Confidential Materials omitted and filed separately with the 
 Securities and
Exchange Commission. Asterisks denote omissions. 
 EXCLUSIVE LICENSE AGREEMENT 
 This agreement, effective as of March 19, 2002 (“Effective Date”), is between the Dana-Farber Cancer Institute, Inc., a Massachusetts
non-profit organization having a principal place of business at 44 Binney Street, Boston, Massachusetts, 02115 (“DFCI”) and GenPath Pharmaceuticals, Inc., a Delaware corporation (“Licensee”). 
 Background 
 DFCI is the
owner of certain rights in technology, as later defined, developed in the laboratories of Dr. Ronald DePinho and Dr. Lynda Chin, subject to patent rights owned by DuPont and to a royalty-free, nonexclusive license previously granted to the
United States Government; and 
 DFCI desires to have the rights used to promote the public interest by granting a license; 
 Licensee has represented to DFCI that it has the capabilities and/or experience to develop and use the technology that is the subject of this Agreement to
develop, produce, market and sell therapeutic and diagnostic products for humans and has the financial capacity and the strategic commitment to facilitate the development of the technology for the public interest; and 
 Licensee desires to obtain a license to DFCI’s rights and DFCI is willing to grant a license upon the terms and conditions of this Agreement.

 DFCI and Licensee therefore agree as follows. 
 Article 1 – Definitions 
  

	1.1	“Agreement” means this Exclusive License Agreement, including all attached schedules. 

  

	1.2	“Affiliate” means any company, corporation or other business entity that is controlled by, controlling, or under common control with Licensee. For this
purpose “control” means direct or indirect beneficial ownership of at least fifty percent (50%) interest in the voting stock (or the equivalent) of the company, corporation or other business or having the right to direct, appoint or
remove a majority of members of its board of directors (or their equivalents) or having the power to control the general management of the company, corporation or other business, by law or contract. 

  

	1.3	“Biological Materials” means the materials supplied by DFCI to Licensee under this Agreement, as identified in Schedule 1, together with any progeny,
or unmodified derivatives of the materials that may be supplied by DFCI or created by Licensee. For the avoidance of doubt, any descendants of any of the mice included in the Biological Materials are themselves Biological Materials.

	1.4	“Developed Products” means any diagnostic, therapeutic or prophylactic product that is discovered, designed, developed or tested by Licensee or any of
its Affiliates or Sublicensees using Licensed Intellectual Property, where the product itself, or the manufacture, use, sale or import of the product, is not covered by any Patent Rights and does not incorporate or use any Biological Materials or
Technical Information. 

  

	1.5	“Field of Use” means all fields of use. 

  

	1.6	“Invention” means inducible mouse models of cancer, including without limitation, RAS and second site suppression models, telomere-based system for
cancer gene discovery and mouse models of cancer based on tissue stem cell transgenesis. 

  

	1.7	“Licensed Process” means any process covered in whole or in part by a Valid Claim of the Patent Rights or which incorporates or uses Biological
Materials or the Technical Information in whole or in part. 

  

	1.8	“Licensed Products” means any product covered in whole or in part by a Valid Claim of the Patent Rights or products manufactured or services or methods
of use provided according to a Licensed Process or products that incorporate or use Biological Materials or Technical Information, in whole or in part. 

  

	1.9	“Licensed Service” means any service utilizing a Licensed Process, a Licensed Product, Biological Materials or the Technical Information, in whole or
in part. 

  

	1.10	“Licensed Intellectual Property” means Patent Rights, Biological Materials or Technical Information, individually or collectively.

  

	1.11	“Net Sales” means the gross income derived by Licensee, its Affiliates or Sublicensees from the Sales of Licensed Products or the provision of Licensed
Services to independent third party customers in bona-fide arms-length transactions less the following deductions, which may not exceed reasonable and customary amounts in the country in which the transaction occurs: 

  

	 	(a)	Transportation charges or allowances actually paid or granted; 

  

	 	(b)	Trade, quantity, cash or other discounts and brokers’ or agents’ commissions, if any, actually allowed and taken; 

  

	 	(c)	Credits or allowances made or given on account of rejects, recalls or returns or retroactive price reductions, or for any amount not collected that are specifically
identifiable to Licensed Products; 

  

	 	(d)	Rebates paid pursuant to government regulations; 

  

	 	(e)	Any tax or governmental charge directly on sale or transportation, use or delivery of products paid by a licensed entity and not recovered from the purchaser.

  

 2 

 Net Sales includes the fair market value of any non-cash consideration from provision of
Licensed Services or sale of Licensed Products received by Licensee, its Affiliates or Sublicensees. 
 Licensed Products and
Licensed Services are considered “Sold” when billed, invoiced or payment is received, whichever occurs first. 
  

	1.12	“Patent Rights” means United States patent applications and disclosures to DFCI listed on Schedule 2, and any conversion, continuation, division, or
substitution thereof, any patents issuing thereon, any reissues, reexaminations or extensions of the patents and any foreign counterparts of the patent applications and patents. 

 Patent Rights existing on the Effective Date are listed on Schedule 2. 
  

	1.13	“Sale” or “Sold” means any grant, sale, lease, assignment, transfer, conveyance or other disposition of Licensed Products or Licensed
Services for value by or on behalf of Licensee, any Affiliate(s) or Sublicensee(s). 

  

	1.14	“Sublicensee” means any natural person or legal entity, which is not an Affiliate, to which Licensee grants a sublicense of some or all of the rights
granted to Licensee under this Agreement. 

  

	1.15	“Technical Information” means proprietary know-how, non-public research information, or unique tangible research materials owned by DFCI and that DFCI
has legal right to convey, which (a) were discovered, invented or developed at DFCI before the Effective Date by the inventors while they were performing research directly related to the Patent Rights and (b) are necessary for practicing
the Invention covered by the Patent Rights or using the Biological Materials and (c) are not covered by the Patent Rights. 

  

	1.16	“Territory” means worldwide. 

  

	1.17	“Valid Claim” means a claim (a) of any issued, unexpired United States or foreign patent, which shall not, in the country of issuance, have been
donated to the public, disclaimed, nor held invalid or unenforceable against the other Party by a court of competent jurisdiction in an unappealed or unappealable decision, or (b) of any United States or foreign patent application, which shall
not, in the country in question, have been cancelled, withdrawn, abandoned nor been pending for more than seven (7) years, not including in calculating such seven-year period time in which such application is in interference or opposition or
similar proceedings or time in which a decision of an examiner is being appealed. 

  

 3 

 Article 2 – Grant of Licenses, Options, Reserved Rights and Sublicensing

  

	2.1.1	License Grants. Subject to all of the terms and conditions of this Agreement and the non-exclusive license granted to the United States government, DFCI grants
to Licensee an exclusive license to DFCI’s right, title and interest under Patent Rights and Biological Materials and a non-exclusive license under DFCI’s right, title and interest in Technical Information, with the right to grant
sublicenses, to make, have made, use, offer to sell, sell and import Licensed Products and Developed Products, to provide Licensed Services and to practice Licensed Processes in the Territory in the Field of Use for the term of this Agreement.

 The license will continue for the term of this Agreement unless the grant is sooner terminated according to
Article 8. 
  

	2.1.2	Option Grants. Subject to the terms and conditions of this Agreement and any non-exclusive license obligated to be granted to the United States government or
other funding agency, DFCI grants to Licensee an exclusive [**] month option, from the date of disclosure in writing by DFCI to Licensee, to obtain an exclusive license, on terms to be negotiated in good faith based on industry standards, to
DFCI’s right, title and interest in future inventions from the laboratory of Dr. Ronald DePinho or Dr. Lynda Chin, the practice of which DFCI believes, in the exercise of its sole reasonable judgment, would infringe Patent Rights.

  

	2.1.3	Biological Materials. DFCI has informed Licensee and Licensee acknowledges that certain items of Biological Materials are covered by U.S. Patents 4,736,866,
5,087,571 and 5,925,803, and corresponding foreign patents, and any patents granted on any divisional and continuation applications thereof, and cannot be transferred to Licensee from DFCI until Licensee enters into a license with E.I DuPont
deNemours, Inc. (“DuPont”) to the above listed patents and DuPont confirms in writing that Licensee has entered into such a license with respect to such item of Biological Materials. DFCI will deliver each such item of Biological Materials
(as indicated by asterisks on Appendix A ) covered by U.S. Patents 4,736,866, 5,087,571 and 5,925,803 to Licensee promptly after such confirmation is obtained for such item. All mice that are part of the Biological Materials are provided as a
bailment, and title to such mice is retained by DFCI. 

  

	2.1.4	Rights to future Improvements made by Licensee. 

  

	 	(a)	All future improvements to the licensed technology developed solely by employees of Licensee (“Licensee Improvements”) will be owned by Licensee. No employee
of DFCI may be considered an employee of Licensee for the purpose of defining Licensee Improvements. 

  

	 	(b)	DFCI is hereby granted the non-exclusive, non-transferable right to make and use Licensee Improvements for research use only within DFCI. 

  

 4 

	2.2	Affiliates. Licensee is entitled to extend its licenses under this Article 2 to its Affiliates, consistent with all of the terms and conditions of this
Agreement. If Licensee does extend its license and an Affiliate assumes obligations under the Agreement, Licensee guarantees performance by the Affiliate. If DFCI has a claim arising under this Agreement against an Affiliate, DFCI may seek a remedy
directly against Licensee and may, but is not is not required to, seek a remedy against the Affiliate. Any termination of the Agreement under Article 8 as to Licensee also constitutes termination as to any Affiliates. 

  

	2.3	No Implied Licenses. This Agreement confers no license or rights by implication, estoppel or otherwise under any other patent applications or patents owned in
whole or in part by DFCI. 

  

	2.4	Reserved Rights. The licenses granted by DFCI are subject to the following reserved rights. 

  

	 	2.4.1	The rights of the United States of America, as set forth in Public laws 96-517 and 98-620, the regulations promulgated thereunder, and the policy of any funding
agencies. Any rights granted hereunder, which are greater than permitted by Public Laws 96-517 and 98-620, are subject to modification as required to conform to the provisions of those statutes. 

  

	 	2.4.2	DFCI’s right to make and use the Licensed Intellectual Property in the Field of Use for teaching, education and non-commercial research purposes, both
laboratory and clinical. 

  

	 	2.4.3	DFCI’s right to supply Biological Materials or Technical Information and grant non-exclusive, non-transferable licenses under Patent Rights to other
academic, governmental or not-for-profit organizations to use Licensed Intellectual Property and make and use Biological Materials for non-commercial research purposes in the Field of Use and not for use in human subjects, clinical trials or for
diagnostic purposes involving human subjects. 

  

	 	2.4.4	All rights in all fields outside the Field of Use. 

  

	2.5	Sublicensing. Licensee has the right to grant sublicenses under this Agreement consistent with the terms and conditions of this Agreement. Licensee remains
responsible for the activities of any Sublicensee under this Agreement, as if the activities were carried out by Licensee. 

  

	 	2.5.1	Notice; Form and Content of Sublicenses. Licensee shall promptly notify DFCI in writing of the identity of any entity to which Licensee reasonably expects to
grant a sublicense. Licensee shall issue any sublicense(s) granted by it under this Agreement in writing and shall attach a copy of this Agreement to all sublicenses. However, Licensee, acting reasonably, may redact information from the copy of this
Agreement that it considers confidential and not necessary for a Sublicensee to understand Licensee’s obligations to DFCI relating to sublicensing. DFCI has the right to review any redaction in advance to confirm that the redacted material is
not necessary for an understanding of Licensee’s obligations to DFCI relating to sublicensing. 

  

 5 

 Licensee shall include the equivalent of at least the following provisions in all
sublicenses: 
  

	 	(a)	Sublicensee shall make payments due to Licensee in relation to Net Sales of Licensed Products in a timely manner, so that Licensee may comply with its obligations to
make payments to DFCI as set forth in Articles 3 and 4 of this Agreement. 

  

	 	(b)	The terms and conditions of Section 2.4, paragraphs 4.2.1 and 4.2.2, Sections 5.2 – 5.5, Sections 6.1 and 6.2, Article 7-10 and 12 of this Agreement are
binding on the Sublicensee. 

  

	 	(c)	Sublicensees do not have the right to grant further sublicenses without the prior written approval by DFCI. 

  

	 	2.5.2	Copies of Sublicenses to DFCI. Licensee shall forward to DFCI a copy of any and all fully executed sublicenses. Licensee shall have the right to redact from any
such sublicenses any information which is unrelated to the obligations of Licensee and the rights of DFCI under this Agreement. Such copy shall be postmarked within thirty (30) days of the execution of the sublicense. Licensee shall also
forward to DFCI annually a copy of the reports received by Licensee from its Sublicensee during the preceding twelve (12) month period under the sublicenses as shall be pertinent to (1) its operations under the sublicense and (2) a
royalty accounting under the sublicense agreement. 

  

	 	2.5.3	Obligation to Sublicense Research Tools. Licensee hereby agrees to make any research tools or research tool applications of the Licensed Intellectual Property
available to the research community, both for-profit and non-profit, in compliance with NIH guidelines, rules or regulations concerning the dissemination of biomedical research tools developed using NIH funding (regardless of the source of funding
used to developed said property). The current NIH Guidelines for sharing research tools are attached hereto as Schedule 3. Failure to comply with such guidelines, rules or regulations will be considered a material breach of this agreement subject to
the terms and conditions of Paragraph 5.1.6 below. 

  

	 	2.5.4	Licensee’s Continuing Obligations. Nothing in Section 2.5 may be construed to relieve Licensee of its obligations to DFCI under this Agreement,
including but not limited to Licensee’s obligations under Article 9. 

  

 6 

 Article 3 – Consideration - Amounts and Time for Payment 
 In consideration of the rights granted by DFCI to Licensee under this Agreement, Licensee shall make the following payments to DFCI according to this
Article 3 and Article 4, on behalf of itself, any Affiliate(s) or Sublicensee(s). 
  

	3.1	Reimbursements and Other Financial Consideration 

  

	 	3.1.1	Past Patent Expenses. Within thirty (30) days after the Effective Date, Licensee shall reimburse DFCI for all out-of-pocket expenses incurred and paid by
DFCI before the Effective Date for filing, prosecuting, maintaining and enforcing Patent Rights. Licensee acknowledges that the total amount of these patent expenses is, as of the Effective Date, [**] dollars ($[**]). 

  

	 	3.1.2	Future Patent Expenses. Licensee shall pay all out-of-pocket patent expenses incurred or paid by DFCI on or after the Effective Date for filing, prosecuting, and
maintaining Patent Rights according to Article 6. Licensee shall pay DFCI within thirty (30) days after DFCI mails Licensee an invoice that documents the out-of-pocket expenses incurred or paid by DFCI during the period being invoiced and
states the total amount owed to DFCI. 

  

	 	3.1.3	Initial License Fee. 

  

	 	(a)	Licensee shall pay to DFCI a non-creditable, non-refundable license royalty fee in the sum of [**] Dollars ($[**]), which is due and payable to DFCI as of the Effective
Date of the Agreement. 

  

	 	(b)	Licensee shall, upon the Effective Date of the Agreement, issue to DFCI One Hundred Thousand (100,000) shares of common stock of GenPath 

 

	 	3.1.4	License Maintenance Fees. On or before each of the first three (3) anniversary dates of the Effective Date of this Agreement, Licensee shall pay DFCI a
non-creditable, non-refundable license maintenance royalty fee of [**] Dollars ($[**]). 

  

	 	3.1.5	Milestone Payments. Licensee shall make the following milestone payments to DFCI within forty-five (45) days of the occurrence of the following events,
whether Licensee, an Affiliate or Sublicensee achieves the events: 

  

	 	(a)	[**] Dollars ($[**]) upon Licensee signing an agreement to enter its first strategic alliance or license agreement that includes the use of the Licensed Intellectual
Property for biological target discovery and that provides for committed funds of any type to Licensee of at least $[**]. Any amounts payable pursuant to Paragraph 3.1.7 below as a sublicense royalty in connection with said target discovery
strategic alliance shall be fully credited against this milestone. 

  

 7 

	 	(b)	[**] Dollars ($[**]) for each of the first [**] targets discovered using the Licensed Intellectual Property in whole or in part, alone or in combination with other
technologies upon validation of such targets. A target will be considered validated for this purpose at the earlier of (i) when it is considered validated under any license to such target granted by Licensee or (ii) when it is determined
that it serves a tumor maintenance role in the inducible cancer models. 

  

	 	3.1.6	Running Royalties. Licensee shall pay DFCI the following running royalties on Net Sales by Licensee and its Affiliates and Sublicensees as follows:

  

	 	(a)	For any Sale of Biological Materials royalties will be paid at the percentage set forth in Paragraph 3.1.7, below, for sublicensing such item; 

 

	 	(b)	[**] percent ([**]%) of Net Sales of Licensed Products; 

  

	 	(c)	[**] percent ([**]%) of the Net Sales of any Licensed Service. 

 DFCI acknowledges that it is anticipated that products discovered, designed, developed or tested using the Licensed Intellectual Property will be Developed Products, rather than Licensed Products, and
thus the running royalties provided in subparagraphs (b) and (c) in this Paragraph 3.1.6 shall not be applicable. 
  

	 	3.1.7	Running Royalty on Sublicensing or Partnering Income. Licensee shall pay DFCI a royalty based on a percentage share of sublicense issue fees, sublicense
milestone payments based on achievement of milestones other than those related to development of Developed Products, sublicense maintenance fees, technology access fees, and any similar payments made by Sublicensees to Licensee or an Affiliate on
account of sublicenses granted under this Agreement. Excluded from these royalty obligations are payments that are fees for services, equity investments, reimbursement of research and development expenses, milestones based on development of
Developed Products and royalties based on Developed Products, Licensed Products or Licensed Services. Shares are to be paid as follows: 

  

	 	(a)	for all sublicensing and partnering agreements entered into by Licensee prior to and including the second anniversary of the Effective Date of this Agreement:

  

	 	(i)	[**] percent ([**]%) for any Biological Materials 

  

	 	(ii)	[**] Percent ([**]%) for any Patent Rights licensed independently of other patent rights owned or controlled by Licensee 

  

	 	(iii)	[**] Percent ([**]%) for any Biological Materials modified by Licensee or a sublicensee or contractor of Licensee 

  

 8 

	 	(iv)	[**] Percent ([**]%) for any Patent Rights licensed in conjunction with other patent rights owned or controlled by Licensee. 

  

	 	(b)	for all sublicensing and partnering agreements entered into by Licensee subsequent to the second anniversary of the Effective Date of this Agreement:

  

	 	(i)	[**] percent ([**]%) for any Biological Materials 

  

	 	(ii)	[**] Percent ([**]%) for any Patent Rights licensed independently of other patent rights owned or controlled by Licensee 

  

	 	(iii)	[**] Percent ([**]%) for any Biological Materials modified by Licensee or a sublicensee or contractor of Licensee 

  

	 	(iv)	[**] Percent ([**]%) for any Patent Rights licensed in conjunction with other patent rights owned or controlled by Licensee. 

 Licensee shall pay these royalties to DFCI within sixty (60) days after the end of each calendar quarter in which the fees and payments
are received by Licensee or its Affiliate. 
  

	 	3.1.8	Legal Fees. Licensee shall reimburse DFCI for legal fees and expenses incurred in the negotiation of this Agreement, not to exceed $[**], within three
(3) days after receipt of an invoice therefor. 

  

	3.2	Waiver or Deferral. Waiver or deferral by DFCI of any payment owed under any paragraph under Section 3.1 may not be construed as a waiver or deferral of any
subsequent payment owed by Licensee to DFCI. 

  

	3.3	Royalty Term. Licensee’s obligation to pay running royalties to DFCI under paragraphs 3.1.6(b) and (c) where the Licensed Product or License Service
does not incorporate or use Biological Materials and under 3.1.7(a)(ii) and (iv) and (b)(ii) and (iv) terminates on a country-by-country basis upon expiration of the last-to-expire patent in the applicable country. However, in recognition
of the ongoing value of the Biological Materials, Licensee shall continue to pay DFCI running royalties on Net Sales of Biological Materials at the rate set forth in paragraph 3.1.6(a) for so long as Biological Materials are sold in the various
country(ies) and under Section 3.1.6(b) and (c) so long as Licensed Products and Licensed Services incorporating Biological Materials are sold in the various country(ies) and running royalties on partnering and sublicensing income as set
forth in paragraph 3.1.7(a)(i) and (iii) and (b)(i) and (iii) for so long as such transactions involving Biological Materials occur. 

  

 9 

 Article 4 – Royalty Reports, Payments and Financial Records 
  

	4.1	Royalty Reports. Within sixty (60) days after March 31, June 30, September 30 and December 31, of each year in which this
Agreement is in effect, Licensee shall deliver to DFCI full, true and accurate reports of its activities and those of its Affiliates or Sublicensee(s), if any, relating to this Agreement during the preceding three month period. These reports must
include at least the following: 

  

	 	(a)	Number of Licensed Products Sold by Licensee, and any Affiliates or Sublicensees, in each country of the Territory; 

  

	 	(b)	Total billings for the Licensed Products Sold; 

  

	 	(c)	Deductions applicable to determining Net Sales; 

  

	 	(d)	The nature and amount of sublicense income received by Licensee that is subject to Section 3.1.7; 

  

	 	(e)	Identification of any events that fulfill the milestones as set forth in paragraph 3.1.5 and the amount owed to DFCI; 

  

	 	(f)	Total royalties due to DFCI; 

 With each report, Licensee shall pay to DFCI the royalties due and payable. If no royalties are due, Licensee shall so report. If multiple Licensed Products are covered by the license granted under this Agreement, Licensee shall separately
identify each Licensed Product in the royalty report and specify which patents/application within Patent Rights, Biological Materials or Technical Information are used for each Licensed Product. 
  

	4.2	Record Keeping. 

  

	 	4.2.1	Books and Records. Licensee shall keep, and shall require its Affiliates and Sublicensees to keep, true books of account containing an accurate record (together
with supporting documentation) of all data necessary for determining the amounts payable to DFCI. Licensee shall keep its records at its principal place of business or the principal place of business of the appropriate division of Licensee to which
this Agreement relates and shall require its Affiliates and Sublicenses to keep their books and records in the same manner. 

  

	 	4.2.2	Inspections. In order for DFCI to determine the correctness of any report or payment made under this Agreement, Licensee shall make its records available to DFCI
for inspection, for a periods of three (3) years following the end of the calendar year to which they pertain. Licensee shall also require any Affiliates or Sublicensees to make their records available for inspection by DFCI, in the same manner
as provided in this paragraph 4.2.2. 

  

 10 

 DFCI may inspect the records during regular business hours by a certified public accountant
selected by DFCI and reasonably acceptable to the licensed entity whose records are being inspected. In conducting inspections under this paragraph 4.2.2, Licensee agrees that DFCI’s accountant may have access to all records which are
reasonably required to calculate royalties owed to DFCI under Article 3. 
 DFCI is responsible for the cost of any inspection,
unless the examination shows an underreporting or underpayment by any entity in excess of five percent for any twelve month period, in which case Licensee shall pay the cost of the inspection as well as any additional sum that would have been
payable to DFCI had the Licensee reported correctly, plus interest as set forth in Section 4.5. 
  

	4.3	Form of Payments and Taxes. Licensee must make all payments to be made to DFCI in Boston, Massachusetts, or at such other place or in such other way as DFCI may
reasonably designate. Payments must be paid by check or wire transfer. 

 The Parties shall use all reasonable and
legal efforts to reduce tax withholding on income realized by DFCI hereunder in countries that do not recognize DFCI’s tax exempt status. Notwithstanding such efforts, if Licensee concludes that tax withholdings under the laws of any country
may be required with respect to such DFCI income, Licensee shall so inform DFCI and provide documentation in support of the anticipated tax liability. Licensee shall further provide DFCI the opportunity to produce documentation in support of its
exemption from such taxes, for use by Licensee in good faith efforts to procure exemption or abatement of DFCI tax liability from the appropriate governmental authority. In such case, Licensee may deduct the anticipated tax liability from DFCI
income hereunder and place such amount in an interest-bearing escrow account designated solely for this purpose. If the appropriate governmental authority denies DFCI request for exemption from taxes, License shall use escrow account funds to pay
such authority. In this case, Licensee will promptly provide DFCI with original receipts or other evidence sufficient to allow DFCI to document such tax withholdings adequately for purposes of claiming any relief or other benefits under United
States and any other relevant tax laws. If DFCI’s claim to tax exemption is accepted by the appropriate governmental authority, Licensee shall immediately release any and all funds in escrow to DFCI. 
  

	4.4	Currency Conversion. If any currency conversion is required in connection with any payment owed to DFCI, the conversion will be made at the average conversion
rate for the transfer of such other currency as quoted by the Wall Street Journal in the applicable accounting period in the case of any payment payable with respect to a specified accounting period or, in the case of any other payment, the last
business day before the date the payment is due. 

  

 11 

	4.5	Interest. Any payment owed to DFCI under this Agreement that is not made when due will accrue interest beginning on the first day following the due date
specified in Article 3. The interest will be calculated at the annual rate of the sum of (a) [**] percent ([**]%) plus (b), the prime interest rate quoted by Fleet Bank on the date the payment is due, the interest being compounded on the last
day of each calendar quarter. However, the annual rate may not exceed the maximum legal interest rate in Massachusetts. The payment of interest as required by this Section does not foreclose DFCI from exercising any other rights or remedies it has
as a consequence of the lateness of any payment. 

 Article 5 – Operations under the License

  

	5.1	Due Diligence 

  

	 	5.1.1	General Obligations. Licensee shall use commercially reasonable efforts to develop and use the Licensed Intellectual Property to develop, produce, market and
sell therapeutic and diagnostic Developed Products and/or Licensed Products. Such efforts shall not be less than the efforts expended by Licensee in connection with its other high priority projects of similar commercial value and will include the
efforts set forth in Section 5.1.3. 

  

	 	5.1.2	Development Plan. Within ninety (90) days after the Effective Date, Licensee shall provide DFCI with a bona fide written development plan that describes
Licensee’s plan for bringing the subject matter of the Licensed Intellectual Property to practical application (“Development Plan”). The Development Plan shall cite Licensee’s specific goals and objectives for the ensuing year
for developing or commercializing the Licensed Intellectual Property and outline Licensee’s plan for achieving the specific due diligence obligations set forth in Section 5.1.3 below. The outline shall include actual or projected financial
resources or strategic alliances that are expected to be required to meet such objectives. 

  

	 	5.1.3	Specific Diligence Benchmarks. Without limiting the generality of Section 5.1.1, Licensee shall use commercially reasonable efforts to meet the following
specific effort and achievement benchmarks (“Diligence Benchmarks”) by the dates specified in this paragraph. 

  

	 	(a)	Licensee shall expend at least the following amounts in the following calendar years specifically directed to developing Developed Products and/or Licensed Products:

  

				
	 Year
	  	Amount
	 2002
	  	$	[**]
	 2003
	  	$	[**]

  

	 	(b)	Within twelve (12) months after the Effective Date: Identification of [**] candidates for therapeutics or diagnostics using the inducible mouse model(s) and/or
MaSS screen and/or telomere-based gene discovery system. 

  

 12 

	 	(c)	Within twenty four (24) months after the Effective Date: Selection of [**] candidate targets with functional activities in cell-culture based assays.

  

	 	(d)	Within twenty four (24) months after the Effective Date: Establishment of [**] additional cancer model for either breast, colon, lung or prostate cancer using the
inducible mouse model system or the stem transgenesis system. 

 For purposes of this paragraph 5.1.3, DFCI will
consider efforts of an Affiliate or Sublicensee as efforts of Licensee. 
  

	 	5.1.4	Adjustments. The Diligence Benchmarks or dates set forth above may be adjusted by mutual agreement by the parties if the inability of Licensee to meet the
benchmarks is due to circumstances reasonably beyond the control of Licensee. 

  

	 	5.1.5	Development and Commercialization Reports. On or before each anniversary of the Effective Date, Licensee shall provide to DFCI a written report describing the
efforts by Licensee, or any Affiliates or Sublicensees, to research, develop and commercialize Developed Products and/or Licensed Products. The report must be in sufficient detail to permit DFCI to monitor Licensee’s compliance with the due
diligence provisions of this Agreement. 

 Licensee shall include at least the following in these reports:
(a) a summary of Licensee’s progress toward meeting the goals and objectives that had been established for the previous year; (b) a summary of Licensee’s goals and objectives for the ensuing year for exploiting the Licensed
Intellectual Property including an identification of additional Licensed Products that Licensee intends to develop, if any; and (c) to the extent not covered by the foregoing, a summary of Licensee’s progress in meeting the Diligence
Benchmarks of Section 5.1.3. 
  

	 	5.1.6	Failure to Perform. Licensee’s failure to comply with any due diligence requirement provided in any paragraph in this Section 5.1 or with the
provisions of Section 2.5.4 is grounds for DFCI to terminate this Agreement according to Section 8.2.3 or to convert this Agreement to a non-exclusive license agreement, at DFCI’s option, which election is DFCI’s sole remedy for
any such failure. The determination of whether such failure has occurred is subject to Article 12. For the avoidance of doubt Licensee’s obligations under 5.1 (b), (c) and (d) is to use commercially reasonable efforts to achieve the
specified milestones, and failure to achieve the specified milestones shall not in and of itself constitute a violation of such subsections. 

  

 13 

	 	5.1.7	Conversion to Non-exclusive License. If any exclusive right or license granted under this Agreement is converted to a non-exclusive license, this Agreement is
automatically amended as follows. With respect to the subject matter of the conversion only, (a) the exclusive license of Section 2.1 becomes a non-exclusive license and the option in Section 2.1.2 terminates, (b) Licensee loses
the right to grant further sublicenses under Section 2.5, provided that, sublicenses granted prior to such conversion shall remain in effect, (c) the obligations of paragraphs 5.1.1, 5.1.2, 5.1.5, 5.1.6 (as it applies to
Section 2.5.4) and 5.1.7 continue to apply but the other paragraphs of Section 5.1 are waived, and (d) the obligation under Section 5.2 no longer applies. 

  

	5.2	U.S. Manufacture. Licensee shall manufacture Licensed Products leased, used or sold in the United States substantially in the United States to the extent
required by 35 U.S.C. 204 and 37 C.F.R. 401 et. seq., as amended. Licensee shall also require any Affiliate(s) or Sublicensee(s) to comply with this U.S. manufacture requirement to the extent required by such laws. 

 If Licensee reasonably believes that domestic manufacture of a Licensed Product is not commercially feasible, at Licensee’s request,
DFCI will cooperate with Licensee to seek a waiver from the United States government with respect to the United States manufacture requirement. If a waiver is to be sought, Licensee shall provide DFCI with the required information, prepare the
initial paperwork necessary for applying for or obtaining the waiver and bear all costs associated with the waiver process. Licensee acknowledges that DFCI can not guarantee that a waiver can or will be obtained. 
  

	5.3	Other Government Laws. Licensee shall comply with, and ensure that its Affiliates and Sublicensees comply with, all government statutes and regulations that
relate to Licensed Products and Biological Materials. These include but are not limited to FDA statutes and regulations, the Export Administration Act of 1979, as amended, codified in 50 App. U.S.C. 2041 et seq. and the regulations promulgated
thereunder or other applicable export statutes or regulations. 

  

	5.4	Patent Marking. To the extent reasonably practical, Licensee shall mark, and shall require its Sublicensees and Affiliates to mark, all Licensed Products sold in
the United States with the word “Patent” and the number or numbers of Patent Rights applicable to the Licensed Product. 

  

	5.5	Publicity – Use of Name. Licensee, its Affiliate and Sublicensees are not permitted to use the names of DFCI, its related entities or its employees, or any
adaptations thereof, in any advertising, promotional or sales literature, or in any securities report required by the Securities and Exchange Commission, without the prior written consent of DFCI in each case. However Licensee may (a) refer to
publications in the scientific literature by employees of DFCI or (b) state that a license from DFCI has been granted as provided in this Agreement. 

  

 14 

 Article 6 – Patent Preparation, Filing, Prosecution and Maintenance 

 

	6.1	Responsibility. DFCI, in its sole discretion, is responsible for preparing, filing, prosecuting and maintaining the patent applications and patents included
within Patent Rights. For purposes of this Agreement, patent prosecution includes ex parte prosecution, interference proceedings, reissues, reexaminations and oppositions. As long as the license remains exclusive, DFCI shall provide, or cause its
agent to provide, copies of relevant correspondence between DFCI and the United States Patent Office or the various foreign patent offices and give Licensee reasonable opportunity to advise DFCI or DFCI’s counsel on such matters. Licensee
designates the following individual or department for receiving the patent-related correspondence. 

 Jane Gunnison

 Fish & Neave 
 1251 Avenue of the Americas 
 New York, New York 10020 
 Upon Licensee’s request, DFCI shall be available in advance to consult with Licensee on matters relating to preparing, filing,
prosecuting or maintaining any of the applications or patents within Patent Rights. DFCI, acting reasonably, shall consider the legitimate interests of Licensee in performing its responsibility under this Section 6.1, and further shall prepare
and file patent applications in all foreign countries requested by Licensee. DFCI designates the following individual or department to receive such requests by Licensee. 
 DFCI Patent Counsel 
 44 Binney Street 
 Boston, MA 02115 
 If DFCI wishes to abandon any patent or filed utility patent application within Patent Rights or not to file any foreign equivalent to a filed U.S. utility application within Patent Rights requested by Licensee, it shall provide reasonable
advance written notice to Licensee and provide Licensee the opportunity, at Licensee’s expense, to assume responsibility for preparing, filing, prosecuting or maintaining the patent application or patent in DFCI’s name. 
  

	6.2	Cooperation. Licensee shall cooperate with DFCI in preparing, filing, prosecuting and maintaining the patent applications and patents within Patent Rights.
Licensee shall provide prompt notice to DFCI of any matter that comes to its attention that may affect the patentability, validity or enforceability of any patent application or patent within Patent Rights. 

  

	6.3	 Relinquishing Rights. Licensee may surrender its licenses under any of the patents or patent applications within Patent Rights in any country of
the licensed Territory by giving [**] days advance written notice to DFCI. However, if Licensee is surrendering any patent or application within Patent Rights on which an interference proceeding or opposition has been

  

 15 

	 	 
declared or filed, the notice period is [**] days. If Licensee so surrenders its rights, it will remain responsible for all patent-related expenses incurred by DFCI during the applicable notice
period. Thereafter, Licensee will have no further obligation to pay any patent expenses for the patents or patent applications that it surrendered. 

  

	6.4	Filing of Certain Patent Applications. The parties acknowledge that those Patent Rights listed in Schedule 2 as [**] have not, as of the Effective Date of the
Agreement, been filed as applications with the US Patent and Trademark Office (“USPTO”) or any other national patenting authority. DFCI will make reasonable efforts consistent with its standard patenting practices to have applications on
both [**] filed with the USPTO in a timely way and in any event no later than May 1, 2002. 

 Article 7
– Patent Infringement and Enforcement 
  

	7.1	Notice. If at any time during the term of this Agreement, Licensee becomes aware of an apparent Substantial Infringement (as defined in Section 7.2) in a
particular country of a patent within Patent Rights, it will promptly notify DFCI. 

  

	7.2	Action by DFCI. 

  

	 	7.2.1	Procedure. (a) DFCI is responsible for enforcing its Patent Rights and prosecuting apparent infringers when, in its judgment, such action may be reasonably
necessary and justified. Licensee may request DFCI to take steps to protect the Patent Rights from an apparent infringement in the Field of Use of an issued patent included in Patent Rights. However, before DFCI must respond to the request, Licensee
shall supply DFCI (i) an opinion of qualified legal counsel demonstrating that an infringement of the Patent Rights in the Field of Use exists in a particular country and (ii) written evidence demonstrating to that a substantial
infringement of the Patent Rights in the Field of Use exists in a particular country (collectively, a “Substantial Infringement”). 

  

	 	7.2.2	Timing. DFCI has forty-five (45) days from the date of receiving satisfactory written evidence from Licensee of a Substantial Infringement to decide whether
it will seek to terminate the Substantial Infringement. DFCI shall give Licensee notice of its decision by the end of this forty-five (45) day period If DFCI notifies Licensee that it intends to prosecute the alleged infringer, then DFCI has
three (3) months from the date of its notice to Licensee to either (a) cause the Substantial Infringement to terminate or (b) initiate legal proceedings against the infringer. If any such suit is brought by DFCI in its own name, or
jointly with Licensee if required by law, it will be at DFCI’s expense and on its own behalf, but DFCI shall not be obligated to bring more than one such suit at a time, provided, that Licensee rights under Section 7.3.1 shall apply with
respect to any Substantial Infringement for which DFCI does not take action. 

  

 16 

	 	7.2.3	Licensee’s Right to Join. Licensee independently has the right to join any legal proceeding brought by DFCI under this Section 7.2 and fund up to fifty
percent (50%) of the cost of the legal proceeding from the date of joining. If Licensee elects to join as a party plaintiff pursuant to this Section 7.2.2, Licensee may jointly participate in the action with DFCI, but DFCI’s counsel
will be lead counsel. 

  

	7.3	Action by Licensee. 

  

	 	7.3.1	Procedure. If DFCI notifies Licensee within the first forty-five (45) day period that it does not intend to prosecute the Substantial Infringement or, if
DFCI fails to cause the Substantial Infringement to terminate or bring legal proceeding to compel termination within three (3) months of the date of its notice to Licensee, then Licensee may initiate legal proceedings against the alleged
infringer, at Licensee’s expense according to the terms of this Section 7.3. Before Licensee commences any legal proceeding with respect to the Substantial Infringement, Licensee shall consider in good faith the views of DFCI, particularly
as they relate to the potential effects on the public interest. Licensee has the right to join DFCI as a party-plaintiff if required by law, at Licensee’s expense. 

  

	 	7.3.2	DFCI’s Right To Join. DFCI independently has the right to join any legal proceeding brought by Licensee under this Section 7.3 and fund up to fifty
percent (50%) of the cost of the legal proceeding from the date of joining. If DFCI elects to join as a party plaintiff pursuant to this paragraph 7.3, DFCI may jointly participate in the action with Licensee, but Licensee’s counsel will
be lead counsel. 

  

	 	7.3.3	Reduction of Royalties. If Licensee initiates legal proceedings under this Section 7.3 in any country and DFCI does not independently join the proceeding,
License may deduct up to [**] percent ([**]%) of Licensee’s documented costs and expenses of the proceeding (including reasonable attorney fees) from running royalties payable to DFCI under paragraphs 3.1.6 and 3.1.7 of this Agreement from
sales of Licensed Products covered by the patent(s)-in-suit or sublicense or partnering income relating to the patent(s)-in-suit. However, Licensee may not reduce DFCI’s royalty payments based upon the patent(s)-in-suit by more than [**]
percent ([**]%) of the amount otherwise due under Article 3. If [**] percent ([**]%) of Licensee’s costs and expenses exceed the amount of royalties deducted by Licensee for any calendar year, Licensee may, to that extent, reduce the royalties
due to DFCI in succeeding calendar quarters for so long as Licensee is actively engaged in legal proceedings to terminate the Substantial Infringement. However, Licensee may not reduce total royalties due to DFCI based upon the patent(s)-in-suit in
a given calendar quarter by more than [**] percent ([**]%). Licensee’s right to reduce royalty payments to DFCI under this paragraph 7.3.3 applies only for so long as the Substantial Infringement continues. 

  

 17 

	 	7.3.4	Settlement. Regardless of whether DFCI is joined or joins any legal proceeding initiated by Licensee, no settlement, consent judgment or other voluntary final
disposition of the legal proceeding may be entered into without the consent of DFCI. 

  

	7.4	Cooperation. If one party initiates legal proceedings to enforce the Patent Rights pursuant to this Article 7, the other party shall cooperate with and supply
all assistance reasonably requested by the party initiating the proceedings, at the initiating party’s request and expense. 

  

	7.5	Distribution of Amounts Paid by Third Parties. In any legal proceeding brought by DFCI under Section 7.2 and funded solely by DFCI, any damages or other
amounts recovered as a result of the proceeding will be retained by DFCI. In any other legal proceeding, any damages or other amounts will be distributed as follows. The damages or other amounts will first be used to reimburse Licensee and DFCI for
litigation costs not paid from royalties and then to reimburse DFCI a sum equivalent to the total amount of royalties and sublicense or partnering income royalties deducted by Licensee under Section 7.3.3. The balance, if any, will be divided
proportionately to their respective out-of-pocket expenses. 

  

	7.6	Declaratory Judgment Actions. In the event that any third party initiates a declaratory judgment action alleging the invalidity or unenforceability of the Patent
Rights, or if any third party brings an infringement action against Licensee or its Affiliates or Sublicensees because of the exercise of the rights granted Licensee under this Agreement, then Licensee shall have the right to defend such action
under its own control at its own expense; provided however, that in the case of declaratory judgement actions DFCI shall have the right to intervene and assume sole control of such defense, at its own expense. Neither Party shall not enter into any
settlement, consent judgment or other voluntary final disposition of any action under this Section 7.6 without the consent of DFCI, which consent shall not be unreasonably withheld unless the settlement includes any express or implied admission
of liability or wrongdoing on DFCI’s part, in which case DFCI’s right to grant or deny consent is absolute and at its sole discretion. Any recovery shall be first applied to reimburse each party pro rata for any out-of pocket expenses it
may have incurred with respect to defense of such action and the remainder shall be retained entirely by the party controlling the action; provided, however, that any recovery for infringement will be distributed as described in Section 7.5.

 Article 8 – Term and Termination 
  

	8.1	Term. Unless terminated earlier under the provisions of this Agreement, this Agreement will terminate on the expiration date of the last to expire of patents
within Patent Rights except that with respect to Licensed Products, Licensed Services or Licensed Processes that utilize Biological Materials, this Agreement will terminate when Licensee ceases to sell such Licensed Products or Licensed Services or
use such Licensed Process. 

  

 18 

	8.2	Termination by Licensor. DFCI has the right to immediately terminate this Agreement and all licenses granted hereunder by providing Licensee with written notice
of termination, upon the occurrence of any of the following events: 

  

	 	(a)	Licensee ceases to carry on its business with respect to Developed Products, Licensed Products or Licensed Processes or ceases to use Biological Materials in its
research and development efforts. 

  

	 	(b)	Licensee fails to pay on schedule any royalty or other payment that has become due and is payable under Articles 3 or 4 of this Agreement and has not cured the default
by making the required payment, together with interest due, within [**] days of receiving a written notice of default from DFCI requesting such payment, provided however, in the event that there is a dispute between the Parties as to any
amounts due, then DFCI shall not have the right to terminate this Agreement with respect to such disputed amounts. If such amounts are subsequently determined to be due, interest shall be payable pursuant to Section 4.5.

  

	 	(c)	Licensee fails to comply with any obligation provided for in Section 5.1 or 2.5.4, unless Licensee has cured the default by meeting the obligation within [**] days
of receiving written notice of default from DFCI. 

  

	 	(d)	Licensee defaults in its obligations to procure and maintain insurance under Section 9.2, unless Licensee has cured the default by meeting the obligation within
[**] days of receiving written notice of default from DFCI. Such ability to cure shall not relieve Licensee of its obligations under Article 9 during the period in which insurance was not in force. 

  

	 	(e)	Licensee is convicted of a felony relating to the manufacture, use, sale or importation of Licensed Products. 

  

	 	(f)	Licensee materially breaches any other provision of this Agreement, unless Licensee has cured the breach within [**] days of receiving written notice from DFCI
specifying the nature of the breach. 

 In the event that any dispute between the Parties as to Licensee’s
compliance with any provision which gives rise to a right of termination by DFCI, then DFCI shall not have the right to terminate this Agreement under this Section 8.2 unless and until such dispute has been resolved pursuant to Article 12.

  

	8.3	Termination by Licensee. Licensee has the right to terminate this Agreement without cause by giving DFCI thirty (30) days prior written notice.

  

	8.4	Effect of Termination. 

  

	 	8.4.1	No release. Upon termination of this Agreement for any reason, nothing in this Agreement may be construed to release either party from any obligation that
matured prior to the effective date of the termination. 

  

 19 

	 	8.4.2	Survival. The provisions of Section 3.1.2 (patent expenses) Article 4 (Royalty Reports, Payments and Financial Records), Section 5.5 (Publicity –
Use of Names), paragraph 8.4.3 (Inventory), Sections 9.1 – 9.5 (Indemnification and Defense), Sections 9.6 – 9.9 (Insurance), Article 11 (Warranty Disclaimers) and Article 12 (Dispute Resolution) survive termination of this Agreement.

  

	 	8.4.3	Inventory. Licensee, any Affiliate(s) and any Sublicensees whose sublicenses are not converted as provided in paragraph 8.4.4, may, after the effective date of
termination, sell all Licensed Products that are in inventory as of the date of written notice of termination, and complete and sell Licensed Products which the licensed entity(ies) can clearly demonstrate were in the process of manufacture as of
the date of written notice of termination, provided that Licensee shall pay to DFCI the royalties thereon as required by Article 3 and shall submit the reports required by Article 4 on the sales of Licensed Products. 

  

	 	8.4.4	Use of Biological Materials. Licensee, any Affiliate(s) and any Sublicensees whose sublicenses are not converted as provided in paragraph 8.4.5, shall cease to
use the Biological Materials and shall certify their proper and humane disposition. 

  

	 	8.4.5	Sublicenses. Any sublicenses will terminate contemporaneously with this Agreement. However, any Sublicensee not in default under its sublicense may request
conversion of the sublicense to a license directly between DFCI and Sublicensee. DFCI shall not unreasonably withhold its acceptance of such conversion, however, as a condition of DFCI’s acceptance, the Sublicensee must first agree to be bound
by all of the provisions of this Agreement and agree that DFCI will have no obligation under the converted sublicense other than the continuation of the license granted therein. 

 Article 9 – Indemnification, Defense and Insurance 
 Indemnification and Defense. 
  

	9.1	Licensee shall indemnify, defend and hold harmless DFCI and its trustees, officers, medical and professional staff, employees, and agents and their respective
successors, heirs and assigns (the “Indemnitees”), against any liability, damage, loss or expense (including reasonable attorneys’ fees and expenses of litigation) incurred by or imposed upon the Indemnitees, or any one of them, in
connection with any claims, suits, actions, demands or judgments (a) arising out of the design, production, manufacture, sale, use in commerce, lease, or promotion by Licensee or by a Sublicensee, Affiliate or agent of Licensee, or any product,
process or service relating to, or developed pursuant to, this Agreement or (b) arising out of any other activities to be carried out pursuant to this Agreement. 

  

 20 

	9.2	Licensee’s indemnification under Section 9.1 (a) applies to any liability, damage, loss or expense whether or not it is attributable to the
negligent activities of the Indemnitees. Licensee’s indemnification under 9.1 (b) does not apply to any liability, damage, loss or expense to the extent that it is attributable to (a) the negligent activities of the Indemnitees, or
(b) the intentional wrongdoing or intentional misconduct of the Indemnitees. 

  

	9.3	Licensee shall, at its own expense, provide attorneys reasonably acceptable to DFCI to defend against any actions brought or filed against any party indemnified
hereunder with respect to the subject of indemnity contained herein, whether or not such actions are rightfully brought. 

  

	9.4	If any such action is commenced or claim made or threatened against DFCI or other Indemnitees as to which Licensee is obligated to indemnify it (them) or hold it
(them) harmless, DFCI or the other Indemnitees shall promptly notify Licensee of such event. Licensee shall assume the defense of, and may settle, that part of any such claim or action commenced or made against DFCI (or other Indemnitees) which
relates to Licensee’s indemnification and Licensee may take such other steps as may be necessary to protect it. Licensee will not be liable to DFCI or other Indemnitees on account of any settlement of any such claim or litigation affected
without Licensee’s consent. The right of Licensee to assume the defense of any action is limited to that part of the action commenced against DFCI and/or Indemnitees that relates to Licensee’s obligation of indemnification and holding
harmless. 

  

	9.5	Licensee shall require any Affiliates or Sublicensee(s) to indemnify, hold harmless and defend DFCI under the same terms set forth in Sections 9.1 – 9.4.

 Insurance. 
  

	9.6	At such time as any product, process or service relating to, or developed pursuant to, this Agreement is being commercially distributed or sold (other than for
the purpose of obtaining regulatory approvals) by Licensee or by a Sublicensee, Affiliate or agent of Licensee, Licensee shall, at its sole cost and expense, procure and maintain policies of commercial general liability insurance in amounts not less
than $[**] per incident and $[**] annual aggregate and naming the Indemnitees as additional insureds. Such commercial general liability insurance must provide (a) product liability coverage and (b) contractual liability coverage for
Licensee’s indemnification under Sections 9.1 through 9.3 of this Agreement. If Licensee elects to self-insure all or part of the limits described above (including deductibles or retentions which are in excess of $[**] annual aggregate), such
self-insurance program must be acceptable to the DFCI and the DFCI’s associated Risk Management Foundation. The minimum amounts of insurance coverage required under these provisions may not be construed to create a limit of Licensee’s
liability with respect to its indemnification obligation under Sections 9.1 through 9.3 of this Agreement. 

  

	9.7	 Licensee shall provide DFCI with written evidence of such insurance upon request of DFCI. Licensee shall provide DFCI with written notice at
least fifteen (15) days prior to the cancellation, non-renewal or material change in such insurance; if

  

 21 

	 	 
Licensee does not obtain replacement insurance providing comparable coverage within such fifteen (15) day period, DFCI has the right to terminate this Agreement effective at the end of such
fifteen (15) day period without any notice or additional waiting periods. 

  

	9.8	Licensee shall maintain such comprehensive general liability insurance beyond the expiration or termination of this Agreement during the period that any product,
process, or service, relating to, or developed pursuant to, this Agreement is being commercially distributed or sold by Licensee or by a Sublicensee, Affiliate or agent of Licensee. 

  

	9.9	Licensee shall require any Affiliates or Sublicensee(s) to maintain insurance in favor of DFCI and the Indemnitees under the same terms set forth in Sections 9.6
– 9.8. 

 Article 10 – Representations; Disclaimer of Warranties 
  

	10.1	DFCI represents and warrants that it has the right to enter into this Agreement and to grant Licensee the licenses granted hereunder. 

 

	10.2	DFCI MAKES NO WARRANTY, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE WITH
RESPECT TO ANY PATENT, TRADEMARK, SOFTWARE, NON-PUBLIC OR OTHER INFORMATION, OR TANGIBLE RESEARCH PROPERTY, LICENSED OR OTHERWISE PROVIDED TO LICENSEE HEREUNDER AND HEREBY DISCLAIMS THE SAME. 

  

	10.3	DFCI DOES NOT WARRANT THE VALIDITY OF THE PATENT RIGHTS LICENSED HEREUNDER AND MAKES NO REPRESENTATION WHATSOEVER WITH REGARD TO THE SCOPE OF THE LICENSED PATENT
RIGHTS OR THAT SUCH PATENT RIGHTS MAY BE EXPLOITED BY LICENSEE, AFFILIATE OR SUBLICENSEE WITHOUT INFRINGING OTHER PATENTS. IF BIOLOGICAL MATERIALS ARE LICENSED HEREUNDER, DFCI MAKES NO REPRESENTATION THAT SUCH MATERIALS OR THE METHODS USED IN MAKING
OR USING SUCH MATERIALS ARE FREE FROM LIABILITY FOR PATENT INFRINGEMENT OR THAT SUCH MATERIALS ARE NOT SUBJECT TO CLAIMS OF JOINT OWNERSHIP BY THIRD PARTIES. 

  

	10.4	THE LIABILITY OF DFCI, ITS AGENTS, OR ITS EMPLOYEES, WITH RESPECT TO ANY AND ALL SUITS, ACTIONS, LEGAL PROCEEDINGS, CLAIMS, DEMANDS, DAMAGES, COSTS AND EXPENSE
ARISING OUT OF THE PERFORMANCE OR NON PERFORMANCE OF ANY OBLIGATION UNDER THIS AGREEMENT WHETHER BASED ON CONTRACT, WARRANTY, TORT (INCLUDING WITHOUT LIMITATION NEGLIGENCE), STRICT LIABILITY, STATUTORY OR OTHERWISE SHALL BE LIMITED TO DIRECT, ACTUAL
DAMAGES INCURRED AS A RESULT OF DFCI’s FAILURE TO PERFORM ITS OBLIGATIONS AS REQUIRED BY THIS AGREEMENT AND SHALL NOT EXCEED IN THE AGGREGATE A SUM EQUAL TO THE TOTAL AMOUNTS PAYABLE TO DFCI UNDER THIS AGREEMENT. 

  

 22 

 Article 11 – Notices 
  

	11.1	Notices to DFCI. Unless otherwise specified in this Agreement, reports, notices and other communications from Licensee to DFCI as provided hereunder must be sent
to: 

 Sr. Vice President for Research 
 Dana-Farber Cancer Institute 
 44 Binney Street 
 Boston, MA 02115 
 or other individuals or addresses as DFCI subsequently furnish by written notice to Licensee. 
 A copy of the notice must also be sent to the attention of DFCI’s Director, Office of Technology Transfer, as the same address as
provided above. 
  

	11.2	Notices to Licensee. Unless otherwise specified in this Agreement, reports, notices and other communications from DFCI to Licensee as provided hereunder must be
sent to: 

 GenPath Pharmaceuticals, Inc. 
 c/o Steven D. Singer 
 Hale and Dorr LLP 
 60 State Street 
 Boston, MA 02109 
 or other individuals or addresses as Licensee subsequently
furnish by written notice to DFCI. 
 Article 12 – Dispute Resolution 
  

	12.1	Negotiation between the Parties. The parties shall first attempt to resolve any controversy that arises from this Agreement, or claim for breach of the
Agreement, by good faith negotiations, first between their respective business development representatives and then, if necessary, between senior representatives for the parties, such as the Sr. Vice President for Research or President of DFCI and
the President of Licensee. 

  

	12.2	Non-Binding Mediation. If the controversy or claim cannot be settled through good faith negotiation between the parties, the parties agree first to try in good
faith to settle their dispute by non-binding mediation under the Mediation Rules of the American Arbitration Association, before resorting to arbitration, litigation or other dispute resolution procedure. 

  

 23 

 Article 13 – Independent Contractor 
  

	13.1	For the purpose of this Agreement and all services to be provided hereunder, both parties are and will be deemed to be, independent contractors and not agents or
employees of the other. Neither party has authority to make any statements, representations or commitments of any kind, or to take any action, that will be binding on the other party. 

 Article 14 – Severability 
  

	14.1	If any one or more of the provisions of this Agreement is held to be invalid, illegal or unenforceable, the validity, legality or enforceability of the remaining
provisions of this Agreement will not in any way be affected or impaired thereby. 

 Article 15 –
Non-assignability 
  

	15.1	Neither this Agreement nor any part of the Agreement is assignable by either party without the express written consent of the other, which consent a party will
not unreasonably withhold. However, Licensee may assign this agreement in conjunction with its merger or the sale of all or substantially all of its assets. Any attempted assignment without such consent is void. 

 Article 16 – Entire Agreement 
  

	16.1	This instrument contains the entire Agreement between the parties. No verbal agreement, conversation or representation between any officers, agents, or employees
of the parties either before or after the execution of this Agreement may affect or modify any of the terms or obligations herein contained. 

 Article 17 – Modifications in Writing 
  

	17.1	No change, modification, extension, or waiver of this Agreement, or any of the provisions herein contained is valid unless made in writing and signed by a duly
authorized representative of each party. 

 Article 18 – Governing Law 
  

	18.1	The validity and interpretation of this Agreement and the legal relations of the parties to it are governed by the laws of the Commonwealth of Massachusetts
without regard to any choice of law principal that would dictate the application of the law of another jurisdiction. 

 Article 19 – Captions 
  

	19.1	The captions are provided for convenience and are not to be used in construing this Agreement. 

  

 24 

 Article 20 – Construction 
  

	20.1	The parties agree that they have participated equally in the formation of this Agreement and that the language herein should not be presumptively construed
against either of them. 

 IN WITNESS WHEREOF, the parties hereto have caused this agreement to be executed in
quadruplicate by their duly authorized representatives as of the date first above written. 
  

									
	DANA-FARBER CANCER	 		 	GENPATH, INC. (LICENSEE)
	INSTITUTE, INC. (DFCI)	 		 	
					
	By:	 	 /s/ Faye C. Austin
	 		 	By:	 	 /s/ Raju Kucherlapati

					
	Title:	 	 Sr. V.P. for Research
	 		 	Title:	 	 Treasurer

					
	Date:	 	 March 19, 2002
	 		 	Date:	 	 March 19, 2002

  

 25 

 Schedule 1 
 Biological Materials 
 [**]. 
  

 26 

 Schedule 2 
 Patent Rights 
 [**] 
  

 27 

 Schedule 3 
 NIH Guidelines for the Sharing of Research Tools 
 Federal Register Notice

 published on Thursday, December 23, 1999 
 [64 FR 72090] 
 DEPARTMENT OF HEALTH AND HUMAN SERVICES 
 National Institutes of Health 
 PRINCIPLES
AND GUIDELINES FOR RECIPIENTS OF NIH RESEARCH GRANTS 
 AND CONTRACTS ON OBTAINING AND DISSEMINATING BIOMEDICAL 
 RESEARCH RESOURCES: FINAL NOTICE 
 AGENCY: National Institutes of Health (NIH), Public Health Service, DHHS 
 SUMMARY: 
 On May 25, 1999 the National Institutes of Health (NIH) published for public comment in the Federal Register a proposed policy entitled SHARING
BIOMEDICAL RESEARCH RESOURCES: Principles and Guidelines for Recipients of NIH Research Grants and Contracts [64 FR 28205]. This policy is designed to provide recipients of NIH funding with guidance concerning appropriate terms for
disseminating and acquiring unique research resources developed with federal funds and is intended to assist recipients in complying with their obligations under the Bayh-Dole Act and NIH funding policy. Comments on the Principles and Guidelines
were requested by August 23, 1999. This Notice presents the final Principles and Guidelines together with NIH’s response to the public comments received. 
 BACKGROUND: 
 The present policy represents part of the overall implementation of
recommendations made by the Advisory Committee to the Director (ACD) to Dr. Harold Varmus, Director, NIH. Dr. Varmus requested that a Working Group of the ACD look into problems encountered in the dissemination and use of proprietary
research tools, the competing interests of intellectual property owners and research users underlying these problems, and possible NIH responses. One of the recommendations in the Report was that NIH issue guidance to the recipients of NIH funding.

 PURPOSE: 
 The present
policy is a two-part document, consisting of Principles setting forth the fundamental concepts and Guidelines providing specific information to patent and license professionals and sponsored research administrators for
implementation. The purpose of these Principles and Guidelines is to assist NIH funding recipients in determining 1) reasonable terms and conditions for making NIH-funded research resources available to scientists in other institutions in the public
and private sectors (disseminating research tools), and 2) restrictions to accept as a condition of receiving access to research tools for use in NIH-funded research (acquiring research tools). The intent is to help Recipients ensure that the
conditions they impose and accept on the transfer of research tools will facilitate further biomedical research, consistent with the requirements of the Bayh-Dole Act and NIH funding agreements. It is also hoped that these Principles and Guidelines
will be adopted by the wider research community so that all biomedical research and development can be synergistic and accelerated. 
  

 28 

 COMMENTS AND AGENCY RESPONSE: 
 The National Institutes of Health (NIH) recognizes the importance of public involvement in the development of policy and sought widespread comment and participation by the various stakeholders in the
biomedical research and development communities regarding the proposed policy. To this end, NIH sought comment not only from NIH grantees, but also from academic, not-for-profit, government, and private sector participants in biomedical research and
development. In order to involve as many stakeholders as possible in the comment process, the proposed policy was advertised and comments solicited in a wide variety of venues. In addition to its publication on May 25, 1999, in the Federal
Register, the proposed policy was made available on several different websites including the Federal Register Online, numerous NIH websites (Edison, NIH Office of Technology Transfer, NIH Office of Extramural Research and the NIH Director’s
Policy Forum), the Association of University Technology Managers (AUTM) website and Recombinant Capital’s Signals Magazine. The proposed policy was also advertised on a variety of e-mail lists (including Techno-L) as well as in direct letters
and e-mail to various stakeholders. In addition, the proposed policy was profiled in articles appearing in a variety of journals and magazines, including Science, Nature and Nature Biotechnology. 
 In response to the May 25 proposal, NIH received 45 letters, each of which contained one or more comments. Comments were received from academic
institutions, scientific foundations, pharmaceutical companies, biotechnology companies (including providers of research instruments, biological reagents and genomic data), an industry trade association, professional societies, individual
researchers and other individual commenters. Below is NIH’s response to comments offered, organized by the section of the proposed policy to which they pertain. 
 Introduction 
 Several commenters suggested that sponsored research administrators be
included within the target audience to which this policy is addressed. This suggestion has been adopted in the final policy. 
 Several
commenters suggested that the policy is a de facto regulation and should either be promulgated in accordance with regulatory process or withdrawn. Several other commenters suggested that as a policy the Principles/Guidelines are not enforceable as
law and that NIH should issue them as a regulation to ensure compliance. The NIH does not believe that a regulation, enforceable as law, is required at this time to facilitate sharing and access to research tools for its Recipients. Although the
final policy is issued as a grants policy, to be incorporated into the NIH Grants Policy Statement, the NIH has not precluded the possibility of engaging in the regulatory process if widespread problems continue in access to NIH-funded research
tools by NIH Recipients. In addition, on a case-by-case basis, the expectations set forth in the Principles and Guidelines may be imposed as specific requirements of NIH funding awards where the Recipient has failed to demonstrate sufficient
progress in implementing the Principles and Guidelines. 
 Some commenters suggested that the policy should not be applicable to all projects
that include NIH grant funds, but that NIH should set a minimum level of NIH funding that would trigger application of the policy. NIH has determined that the establishment of such a threshold would not be consistent with NIH’s objective of
ensuring that broad availability of research tools. 
  

 29 

 One commenter expressed concern that the proposed policy, if applied to recipients of Small Business
Innovation Research (SBIR) grants, would place SBIR recipients under conflicting directives. The commenter suggests that because SBIR recipients are required, as a condition of their grant, to focus on the commercialization of technology, they would
be unable to disseminate research tools with the minimal intellectual property encumbrances advocated by the proposed policy. SBIR Recipients, like other NIH grantees, are subject to the dual obligations of disseminating unique research resources
while promoting utilization, commercialization and public availability of their inventions. The NIH does not see a conflict between these obligations. The NIH invites its SBIR grantees to consult with their project officer in the event they
encounter difficulty in the interpretation or implementation of this policy, either in general or with respect to particular unique research resources developed under their grant. 
 Principles 
 1. Ensure Academic Freedom and Publication 
 Several commenters suggested that language be added to the guidelines to prohibit recipients from making coauthorship a condition of providing research
tools. There appears to be general consensus within the research community that authorship is properly based upon significant intellectual contribution to the published paper. In most cases, simply making available research materials will not, in
the absence of other contributions, justify coauthorship. (See e.g., Responsible Science, Volume I: Ensuring the Integrity of the Research Process, Panel on Scientific Responsibility and the Conduct of Research, National Academy Press, 1992,
p. 52). The final policy as been amended to reflect this view. 
 Several commenters expressed concern that the definition of
“Recipient” in the proposed policy might not include individuals or entities receiving NIH funds through “cooperative agreements.” The policy is applicable to cooperative agreements and this has been clarified in the Principles
and Guidelines. 
 2. Ensure Appropriate Implementation of the Bayh-Dole Act 
 Virtually all commenters requested clarification on how this policy would preserve incentives for the development and production of research tools that are
ultimately sold as products to the research community. The policy has been clarified to ensure that where patent protection is necessary for development of a research tool as a potential product for sale and distribution to the research community,
Recipients are not discouraged from seeking such protection, but should license the intellectual property in a manner that maximizes the potential for broad distribution of the research tool. The policy is not intended to require Recipient
scientists to develop or maintain tools for widespread distribution, to discourage development of research tool products, nor to set or influence the price for research tools that are commercial products. 
 3. Minimize Administrative Impediments to Academic Research 
 One commenter suggested that reach-through rights should not be discouraged because they are sometimes helpful to Recipients by allowing them to obtain materials and equipment at reduced or nominal
upfront cost. NIH is aware of this rationale for a Recipient agreeing to reach-through but finds that such practices contribute not only to specific restriction of access to subsequent tools arising out of the NIH-funded work, but also to the
general proliferation of multiple ties and competing interests that is the source of the

  

 30 

 
current access problems. NIH does not support the coupling of procurement with intellectual property rights and restrictions and expects Recipients to ensure that NIH-funded tools are not
restricted as a result of such agreements. Therefore, Recipients should engage in such interactions on an infrequent, case-by-case, and highly controlled and monitored basis. 
 4. Ensure Dissemination of Research Resources Developed with NIH Funds 
 Numerous comments
were received concerning the conditions under which research tools developed by recipients of NIH funds are to be transferred to for-profit entities. The comments received reflected the wide range of opinions present within the life sciences
community on this point. On the one hand, some commenters urged that transfer of research tools to for-profit entities be carried out under the same terms as transfers to nonprofits/academic institutions. These commenters argue that because of the
increasingly important role research tools play in the discovery and development of new therapeutic compounds, it is critical that these tools be made available to for-profit entities free of onerous contractual provisions. They argue that by
adopting a transfer policy similar to that proposed for transfers to academic laboratories, NIH will ensure that the public will reap the benefit of its investment in government research in the form of new and improved pharmaceuticals. Other
commenters opposed the general idea that the terms for transferring tools to for-profit entities should be identical to those for transfers of tools to academic and non-profit organizations. They argue that the fundamental differences in mission
between for-profit entities and academic institutions justify different treatment with respect to the terms under which each obtains and uses tools. 
 In the final policy, the NIH has left considerable discretion to Recipients in determining how to achieve the principle of ensuring appropriate distribution of NIH-funded tools. As articulated by the policy, imposing reach-through royalty
terms as a condition of use of a research tool is inconsistent with this principle. When transferring an NIH-funded research tool to a for-profit entity that intends to use the tool for its own internal purposes, Recipients are entitled to capture
the value of their invention. Arrangements such as execution or annual fees are an appropriate way for Recipients to do so. Royalties on the sale of a final product that does not embody the tool, or other reach-through rights directed to a final
product that does not embody the tool, discourage use of tools and are not appropriate in these circumstances. Royalties on the sale of final products are more appropriate to situations where a for-profit entity seeks to commercialize the tool,
e.g., by developing a marketable product or service, or incorporating the tool into a marketable product or service. 
 Appendix A
Guidelines for Implementation 
 The final policy has been clarified with regard to NIH intent in attaching the more specific Guidelines
to the general Principles. The Principles set forth the policy that NIH is issuing to its funding Recipients to assist them in fulfilling the dual obligations imposed by NIH grants policy with respect to the dissemination of unique research
resources, and the Bayh-Dole Act with respect to utilization, commercialization and public availability of government funded inventions. These dual obligations must be thoughtfully managed. The Guidelines provide further information, model language,
and suggested strategies for implementing the Principles. The model language and strategies provided by the Guidelines are not intended as the sole means by which Recipients may implement the

  

 31 

 
articulated Principles. It is the nature of advancing science and technology to present unique factual circumstances, and NIH expects that Recipients will determine the most appropriate means to
achieve the Principles for unique technologies when the Guidelines do not provide a workable strategy. 
 Several commenters suggested that
research tools be better defined and that more examples be used to assist in determining whether the policy should be applied and if so, what licensing strategy is appropriate. For example, one commenter suggested that the policy draw a distinction
between “broad platform technologies” and “product-specific technologies” when determining whether an exclusive license is appropriate. The final policy provides clarification of the criteria that Recipients might apply in
determining how to handle a particular technology. 
 One commenter requested that the definition of research tools be expanded to include
diagnostic genetic tests performed with “home-brew” reagents. The commenter suggested that the patenting and exclusive licensing of such tests is having a deleterious effect on clinical education, clinical research, and patient care. NIH
declines to expand the definition of research tools to include diagnostic genetic tests. Where such tests are patented and licensed to for-profit entities, academic medical centers wishing to use such licensed tests in their clinical programs should
negotiate terms of use with the commercial licensee. 
 Many commenters were of the opinion that the thirty-day time limit for disclosure of
research findings was too short. The final policy has been amended to state that a delay of 30-60 days is generally viewed as reasonable. This amendment is in accord with previous NIH guidance on sponsored research agreements, Developing Sponsored
Research Agreements: Considerations for Recipients of NIH Research Grants and Contracts, 59 FR 55674. 
 Comments were received in favor of
adopting the Simple Letter Agreement as a free-standing, one page, uniform material transfer agreement. If used by the NIH intramural program and NIH grantees, commenters believe that the majority of transfers among and between
not-for-profits and government laboratories would be greatly simplified. In response to specific comments, the Simple Letter Agreement has been significantly edited and updated. Recipients are encouraged to adopt the Simple Letter Agreement as their
institution’s model Material Transfer Agreement (MTA), and are expected to use the terms of the Simple Letter Agreement, or no more restrictive terms, for transfers of unpatented materials developed with NIH funding to other NIH grantees.

 FOR FURTHER INFORMATION CONTACT: Ms. Barbara McGarey, J.D., NIH Office of Technology Transfer, 6011 Executive Boulevard, Suite
325, Rockville, MD 20852-3804; Fax: (301) 402-3257; E-mail: NIHOTT@od.nih.gov. 
 /s/ 
 Maria C. Freire, Ph.D. 
 Director, Office of
Technology Transfer 
 National Institutes of Health 
 Certified to be a true copy of the original document 
  

 32 

 SHARING BIOMEDICAL RESEARCH RESOURCES: 
 Principles and Guidelines for Recipients of NIH Research Grants and Contracts 
 INTRODUCTION 
 The National Institutes of Health is dedicated to the advancement of health through science. As a public sponsor
of biomedical research, NIH has a dual interest in accelerating scientific discovery and facilitating product development. In 1997, Dr. Harold Varmus, Director, NIH requested that a Working Group of the Advisory Committee to the Director look
into problems encountered in the dissemination and use of unique research resources, the competing interests of intellectual property owners and research tool users, and possible NIH responses.1 The Working Group found that intellectual property restrictions can stifle the broad dissemination of new
discoveries and limit future avenues of research and product development. At the same time, reasonable restrictions on the dissemination of research tools are sometimes necessary to protect legitimate proprietary interests and to preserve incentives
for commercial development. One of the recommendations of the Working Group was that NIH issue guidance to its funding recipients to help them achieve the appropriate balance. That guidance is provided in this two-part document, consisting of
Principles setting forth the fundamental concepts and Guidelines that provide specific information to patent and license professionals and sponsored research administrators for implementation. A copy of the full Report of the Working
Group, with more detailed background information, is available at the NIH web site, www.nih.gov/welcome/forum, or from the NIH Office of the Director. 
  

	1	The term “unique research resource” is used in its broadest sense to embrace the full range of tools that scientists use in the laboratory, including cell
lines, monoclonal antibodies, reagents, animal models, growth factors, combinatorial chemistry and DNA libraries, clones and cloning tools (such as PCR), methods, laboratory equipment and machines. The terms “research tools” and
“materials” are used throughout this document interchangeably with “unique research resources.” Databases and materials subject to copyright, such as software, are also research tools in many contexts. Although the information
provided here may be applicable to such resources, the NIH recognizes that databases and software present unique questions which cannot be fully explored in this document. 

  

 33 

 PRINCIPLES 
 1. Ensure Academic Freedom and Publication 
 Academic research freedom based upon
collaboration, and the scrutiny of research findings within the scientific community, are at the heart of the scientific enterprise. Institutions that receive NIH research funding through grants, cooperative agreements or contracts
(“Recipients”) have an obligation to preserve research freedom, safeguard appropriate authorship, and ensure timely disclosure of their scientists’ research findings through, for example, publications and presentations at scientific
meetings. Recipients are expected to avoid signing agreements that unduly limit the freedom of investigators to collaborate and publish, or that automatically grant co-authorship or copyright to the provider of a material. 
 Reasonable restrictions on collaboration by academic researchers involved in sponsored research agreements with an industrial partner that avoid conflicting
obligations to other industrial partners, are understood and accepted. Similarly, brief delays in publication may be appropriate to permit the filing of patent applications and to ensure that confidential information obtained from a sponsor or the
provider of a research tool is not inadvertently disclosed. However, excessive publication delays or requirements for editorial control, approval of publications, or withholding of data all undermine the credibility of research results and are
unacceptable. 
 2. Ensure Appropriate Implementation of the Bayh-Dole Act 
 When a Recipient’s research work is funded by NIH, the activity is subject to various laws and regulations, including the Bayh-Dole Act (35 U.S.C. 200
et seq.). Generally, Recipients are expected to maximize the use of their research findings by making them available to the research community and the public, and through their timely transfer to industry for commercialization. 
 The right of Recipients to retain title to inventions made with NIH funds comes with the corresponding obligations to promote utilization,
commercialization, and public availability of these inventions. The Bayh-Dole Act encourages Recipients to patent and license subject inventions as one means of fulfilling these obligations. However, the use of patents and exclusive licenses is not
the only, nor in some cases the most appropriate, means of implementing the Act. Where the subject invention is useful primarily as a research tool, inappropriate licensing practices are likely to thwart rather than promote utilization,
commercialization and public availability of the invention. 
 In determining an intellectual property strategy for an NIH-funded invention
useful primarily as a research tool, Recipients should analyze whether further research, development and private investment are needed to realize this primary usefulness. If it is not, the goals of the Act can be met through publication, deposit in
an appropriate databank or repository, widespread non-exclusive licensing or any other number of dissemination techniques. Restrictive licensing of such an invention, such as to a for-profit sponsor for exclusive internal use, is antithetical to the
goals of the Bayh-Dole Act. Where private sector involvement is desirable to assist with maintenance, reproduction, and/or distribution of the tool, or because further research and development are needed to realize the

  

 34 

 
invention’s usefulness as a research tool, licenses should be crafted to fit the circumstances, with the goal of ensuring widespread and appropriate distribution of the final tool product.
Exclusive licensing of such an invention, such as to a distributor that will sell the tool or to a company that will invest in the development of a tool from the nascent invention, can be consistent with the goals of the Bayh-Dole Act. 

3. Minimize Administrative Impediments to Academic Research 
 Each iteration in a negotiation over the terms of a license agreement or materials transfer agreement delays the moment when a research tool may be put to use in the laboratory. Recipients should take
every reasonable step to streamline the process of transferring their own research tools freely to other academic research institutions using either no formal agreement, a cover letter, the Simple Letter Agreement of the Uniform Biological Materials
Transfer Agreement (UBMTA), or the UBMTA itself. The Appendix contains an updated free-standing version of the Simple Letter Agreement that is strongly encouraged for transfers of unpatented research materials among Recipients. 
 Where they have not already done so, Recipients should develop and implement clear policies which articulate acceptable conditions for acquiring resources,
and refuse to yield on unacceptable conditions. NIH acknowledges the concern of some for-profit organizations that the concept of purely academic research may be diluted by the close ties of some not-for-profit organizations with for-profit
entities, such as research sponsors and spin-off companies in which such organizations take equity. Of concern to would-be providers is the loss of control over a proprietary research tool that, once shared with a not-for-profit Recipient for
academic research, results in commercialization gains to the providers’ for-profit competitors. Recipients must be sensitive to this legitimate concern if for-profit organizations are expected to share tools freely. 
 For-profit organizations, in turn, must minimize the encumbrances they seek to impose upon not-for-profit organizations for the academic use of their tools.
Reach-through royalty or product rights, unreasonable restraints on publication and academic freedom, and improper valuation of tools impede the scientific process whether imposed by a not-for-profit or for-profit provider of research tools. While
these Principles are directly applicable only to recipients of NIH funding, it is hoped that other not-for-profit and for-profit organizations will adopt similar policies and refrain from seeking unreasonable restrictions or conditions when sharing
materials. 
 4. Ensure Dissemination of Research Resources Developed with NIH Funds 
 Progress in science depends upon prompt access to the unique research resources that arise from biomedical research laboratories throughout government,
academia, and industry. Ideally, these new resources flow to others who advance science by conducting further research. Prompt access can be accomplished in a number of ways, depending on the type of resource that has been developed, whether it has
broad or specific uses, and whether it is immediately useful or private sector investment is needed to realize its usefulness. The goal is widespread, timely distribution of tools for further discovery. When research tools are used only within one
or a small number of institutions, there is a great risk that fruitful avenues of research will be neglected. 
 Unique research resources
arising from NIH-funded research are to be made available to the scientific research community. Recipients are expected to manage interactions with third parties that have the potential to restrict Recipients’ ability to disseminate

  

 35 

 
research tools developed with NIH funds.2 For example, a Recipient might use NIH funds with funds from one or more third party sponsors, or acquire a research tool from a third party provider for use in an NIH-funded research project. Either
situation may result in a Recipient incurring obligations to a third party that conflict with Recipient’s obligations to the NIH. To avoid inconsistent obligations, Recipients are encouraged to share these Principles with potential co-sponsors
of research projects and third party providers of materials. 
 Recipients should also examine and, where appropriate, simplify the transfer of
materials developed with NIH funds to for-profit institutions for internal use by those institutions. NIH endorses distinguishing internal use by for-profit institutions from the right to commercial development and sale or provision of services. In
instances where the for-profit institution is seeking access for internal use purposes, Recipients are encouraged to transfer research tools developed with NIH funding to such institutions without seeking option rights or royalties on the final
product. 
  

	2	 Research tools obtained or derived from human tissues constitute a special case. Certain restrictions on the use and further dissemination of such
tools may be appropriate to ensure consistency with donor consent and human subjects protection. See 45 C.F.R. Part 46. 

 SUMMARY 
 Access to research tools is a prerequisite to continuing scientific advancement. Ensuring broad access while
preserving opportunities for product development requires thoughtful, strategic implementation of the Bayh-Dole Act. The NIH urges Recipients to develop patent, license, and material sharing policies with this goal in mind, realizing both product
development as well as the continuing availability of new research tools to the scientific community. 
 APPENDIX

 GUIDELINES FOR IMPLEMENTATION 
 The following Guidelines provide specific information, strategies, and model language for patent and license professionals and sponsored research administrators at Recipient institutions to assist in
implementing the Principles on Obtaining and Disseminating Biomedical Resources. Recipients are encouraged to use the strategies below, other strategies developed at their own institutions, or any other appropriate means of achieving the Principles.

 Guidelines for Disseminating Research Resources Arising Out of NIH-Funded Research 
 Definition of Research Tools 
  

	 	•	 	 The definition of research tools is necessarily broad, and it is acknowledged that the same material can have different uses, being a research tool in
some contexts and a product in others. In determining how an NIH-funded resource that falls within the definition should be handled, Recipients should determine whether: 1) the primary usefulness of the resource is as a tool for discovery rather
than an FDA-approved product or integral component of such a product; 2) the resource is a

  

 36 

	 	 
broad, enabling invention that will be useful to many scientists (or multiple companies in developing multiple products), rather than a project or product-specific resource; and 3) the resource
is readily useable or distributable as a tool rather than the situation where private sector involvement is necessary or the most expedient means for developing or distributing the resource. Recipients should ensure that their intellectual property
strategy for resources fitting one or more of the above criteria enhances rather than restricts the ultimate availability of the resource. If Recipient believes private sector involvement is desirable to achieve this goal, Recipient should
strategically license the invention under terms commensurate with the goal. 

 Use of Simple Letter Agreement

  

	 	•	 	 Recipients are expected to ensure that unique research resources arising from NIH-funded research are made available to the scientific research
community. The majority of transfers to not-for-profit entities should be implemented under terms no more restrictive than the UBMTA. In particular, Recipients are expected to use the Simple Letter Agreement provided below, or another document with
no more restrictive terms, to readily transfer unpatented tools developed with NIH funds to other Recipients for use in NIH-funded projects. If the materials are patented or licensed to an exclusive provider, other arrangements may be used, but
commercialization option rights, royalty reach-through, or product reach-through rights back to the provider are inappropriate. 

  

	 	•	 	 Similarly, when for-profit entities are seeking access to NIH-funded tools for internal use purposes, Recipients should ensure that the tools are
transferred with the fewest encumbrances possible. The Simple Letter Agreement may be expanded for use in transferring tools to for-profit entities, or simple internal use license agreements with execution or annual use fees may be appropriate.

  

	 	•	 	 Simple Letter Agreement for the Transfer of Materials  

 In response to the RECIPIENT’s request for the MATERIAL [insert description]
                                         the
PROVIDER asks that the RECIPIENT and the RECIPIENT SCIENTIST agree to the following before the RECIPIENT receives the MATERIAL: 
 1. The above MATERIAL is the property of the PROVIDER and is made available as a service to the research community. 
 2. THIS MATERIAL IS NOT FOR USE IN HUMAN SUBJECTS. 
 3. The MATERIAL will be used for teaching or
not-for-profit research purposes only. 
 4. The MATERIAL will not be further distributed to others without the
PROVIDER’s written consent. The RECIPIENT shall refer any request for the MATERIAL to the PROVIDER. To the extent supplies are available, the PROVIDER or the PROVIDER SCIENTIST agree to make the MATERIAL available, under a separate Simple
Letter Agreement to other scientists for teaching or not-for-profit research purposes only. 
 5. The RECIPIENT agrees to
acknowledge the source of the MATERIAL in any publications reporting use of it. 
  

 37 

 6. Any MATERIAL delivered pursuant to this Agreement is understood to be experimental in
nature and may have hazardous properties. THE PROVIDER MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR
THAT THE USE OF THE MATERIAL WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER PROPRIETARY RIGHTS. Unless prohibited by law, Recipient assumes all liability for claims for damages against it by third parties which may arise from the use,
storage or disposal of the Material except that, to the extent permitted by law, the Provider shall be liable to the Recipient when the damage is caused by the gross negligence or willful misconduct of the Provider. 
 7. The RECIPIENT agrees to use the MATERIAL in compliance with all applicable statutes and regulations. 
 8. The MATERIAL is provided at no cost, or with an optional transmittal fee solely to reimburse the PROVIDER for its preparation and
distribution costs. If a fee is requested, the amount will be indicated here: [insert fee]                      
 The PROVIDER, RECIPIENT and RECIPIENT SCIENTIST must sign both copies of this letter and return one signed copy to the PROVIDER. The
PROVIDER will then send the MATERIAL. 
 PROVIDER INFORMATION and AUTHORIZED SIGNATURE 
  

							
		 	Provider Scientist:	  	  
	  	

							
		 	Provider Organization:	  	  
	  	

							
		 	Address:	  	  
	  	

							
		 	Name of Authorized Official:	  	  
	  	

							
		 	Title of Authorized Official:	  	  
	  	

 Certification of Authorized Official: This Simple Letter Agreement
     has /      has not [check one] been modified. If modified, the modifications are attached. 
  

							
		 	  
	  	  
	  	
		 	Signature of Authorized Official Date	  	

 RECIPIENT INFORMATION and AUTHORIZED SIGNATURE 
  

							
		 	Recipient Scientist:	  	  
	  	

							
		 	Recipient Organization:	  	  
	  	

							
		 	Address:	  	  
	  	

							
		 	Name of Authorized Official:	  	  
	  	

							
		 	Title of Authorized Official:	  	  
	  	

							
		 	Signature of Authorized Official:	  	  
	  	

							
		 	Date:	  	  
	  	

 Certification of Recipient Scientist: I have read and understood the conditions
outlined in this Agreement and I agree to abide by them in the receipt and use of the MATERIAL. 
  

							
		 	  
	  	  
	  	
		 	Recipient Scientist Date	  	

  

 38 

 Ensuring Consistent Obligations 
  

	 	•	 	 Recipients must ensure that obligations to other sources of funding of projects in which NIH funds are used are consistent with the Bayh-Dole Act and
NIH funding requirements. Unique research resources generated under such projects are expected to be made available to the research community. Recipients are encouraged to share these Guidelines with potential co-sponsors. Any agreements covering
projects in which NIH funds will be used along with other funds are expected to contain language to address the issue of dissemination of unique research resources. Examples of possible language follow. The paragraphs are presented in a “mix
and match” format: 

 “The project covered by this agreement is supported with funding from the
National Institutes of Health. Provider agrees that upon publication, unpatented unique research resources arising out of this project may be freely distributed.” 
 “In the event an invention is primarily useful as a research tool, any option granted shall either be limited to a non-exclusive license or the terms of any resulting exclusive license shall
include provisions that ensure that the research tool will be available to the academic research community on reasonable terms.” 
 “Provider agrees that Recipient shall have the right to make any materials and inventions developed by Recipient in the course of the collaboration (including materials and inventions developed
jointly with Provider, but not including any Provider materials (or parts thereof) or Provider sole inventions available to other scientists at not-for-profit organizations for use in research, subject to Provider’s independent intellectual
property rights.” 
 “Subject to Recipient’s obligations to the U.S. government, including 37 CFR Part 401,
the NIH Grants Policy Statement, and the NIH Guidelines for Obtaining and Disseminating Biomedical Research Resources, Recipient grants to Sponsor the following rights:...” 
 Limiting Exclusive Licenses to Appropriate Field of Use 
  

	 	•	 	 Exclusive licenses for research tools (where no further research and development is needed to realize the invention’s usefulness as a tool) should
generally be avoided except in cases where the licensee undertakes to make the research tool widely available to researchers through unrestricted sale, or the licensor retains rights to make the research tool widely available. When an exclusive
license is necessary to promote investment in commercial applications of a subject invention that is also a research tool, the Recipient should ordinarily limit the exclusive license to the commercial field of use, retaining rights regarding use and
distribution as a research tool. Examples of possible language include: 

 ““Research
License” means a nontransferable, nonexclusive license to make and to use the Licensed Products or Licensed Processes as defined by the Licensed Patent Rights for purposes of research and not for purposes of commercial 

  

 39 

 
manufacture, distribution, or provision of services, or in lieu of purchase, or for developing a directly related secondary product that can be sold. Licensor reserves the right to grant such
nonexclusive Research Licenses directly or to require Licensee to grant nonexclusive Research Licenses on reasonable terms. The purpose of this Research License is to encourage basic research, whether conducted at an academic or corporate facility.
In order to safeguard the Licensed Patent Rights, however, Licensor shall consult with Licensee before granting to commercial entities a Research License or providing to them research samples of the materials.” 
 “Licensor reserves the right to provide the Biological Materials and to grant licenses under Patent Rights to not-for-profit and
governmental institutions for their internal research and scholarly use.” 
 “Notwithstanding anything to the
contrary in this agreement, Licensor shall retain a paid-up, nonexclusive, irrevocable license to practice, and to sublicense other not-for-profit research organizations to practice, the Patent Rights for internal research use.” 

“The grant of rights provided herein is subject to the rights of the United States government pursuant to the Bayh-Dole Act and is
limited by the right of the Licensor to use Patent Rights for its own research and educational purposes and to freely distribute Materials to not-for-profit entities for internal research purposes.” 
 “Licensor reserves the right to supply any or all of the Biological Materials to academic research scientists, subject to limitation
of use by such scientists for research purposes and restriction from further distribution.” 
 “Licensor
reserves the right to practice under the Patent Rights and to use and distribute to third parties the Tangible Property for Licensor’s own internal research purposes.” 
 Guidelines For Acquiring Research Resources For Use in NIH-Funded Research 
 Prompt
Publication 
  

	 	•	 	 Agreements to acquire materials for use in NIH-funded research are expected to address the timely dissemination of research results. Recipients should
not agree to significant publication delays, any interference with the full disclosure of research findings, or any undue influence on the objective reporting of research results. A delay of 30-60 days to allow for patent filing or review for
confidential proprietary information is generally viewed as reasonable. 

 Definition of Materials 
  

	 	•	 	 Under the Bayh-Dole Act and its implementing regulations, agreements to acquire materials for use in NIH-funded projects cannot require that title to
resulting inventions be assigned to the provider. For this reason, definitions of “materials” that include all derivatives or modifications are unacceptable. Other unacceptable variations include definitions of “materials” that
include any improvements, or any other materials that could not have been made without the provided material.

  

 40 

	 	 
Conversely, it is important for providers of materials to be aware that a Recipient does not gain any ownership or interest in a provider’s material by virtue of the Recipient using the
material in an NIH-funded activity. Examples of acceptable definitions for “materials” include: 

 ““Materials” means the materials provided as specified in this document.” 
 ““Materials” means the materials provided as specified in this document. Materials may also include Unmodified Derivatives of the materials provided, defined as substances created by the Recipient which constitute an
unmodified functional subunit or product expressed by the original material, such as subclones of unmodified cell lines, purified or fractionated subsets of the original material, proteins expressed by DNA/RNA supplied by the Provider, or monoclonal
antibodies secreted by a hybridoma cell line.” 
 ““Materials” means the materials provided as
specified in this document. Materials may also include Progeny and Unmodified Derivatives of the materials provided. Progeny is an unmodified descendant from the original material, such as virus from virus, cell from cell, or organism from organism.
Unmodified Derivatives are substances created by the Recipient which constitute an unmodified functional subunit or product expressed by the original material, such as subclones of unmodified cell lines, purified or fractionated subsets of the
original material, proteins expressed by DNA/RNA supplied by the Provider, or monoclonal antibodies secreted by a hybridoma cell line.” 
 ““Materials” means the material being transferred as specified in this document. Materials shall not include: (a) Modifications, or (b) other substances created by the
recipient through the use of the Material which are not Modifications, Progeny, or Unmodified Derivatives. Progeny is an unmodified descendant from the Material, such as virus from virus, cell from cell, or organism from organism. Unmodified
Derivatives are substances created by the Recipient which constitute an unmodified functional subunit or product expressed by the original Material, such as subclones of unmodified cell lines, purified or fractionated subsets of the original
Material, proteins expressed by DNA/RNA supplied by the Provider, or monoclonal antibodies secreted by a hybridoma cell line.” [Source: Uniform Biological Materials Transfer Agreement; terms defined therein] 
 Ensuring Consistent Obligations 
  

	 	•	 	 Recipients are expected to avoid signing agreements to acquire research tools that are likely to restrict Recipients’ ability to promote broad
dissemination of additional tools that may arise from the research. This might occur when an agreement gives a provider an exclusive license option to any new intellectual property arising out of the project. A new transgenic mouse developed during
the project could fall under this license option and become unavailable to third party scientists as a result. Examples of agreements to examine include material transfer agreements (MTAs), memoranda of understanding (MOU), research or collaboration
agreements, and sponsored research agreements. Recipients should consider adopting standard language to place in such agreements to address this issue. The following are examples of possible language to include in MTAs, sponsored research
agreements, and other agreements that either acquire materials from or co-mingle funds with non-government sources. The paragraphs are presented in a “mix and match” format: 

 “The project covered by this agreement is supported with funding from the National Institutes of Health. Provider agrees that after
publication, unpatented unique research resources arising out of this project may be freely distributed.” 
  

 41 

 “In the event an invention is primarily useful as a research tool, any option
granted shall either be limited to a non-exclusive license or the terms of any resulting exclusive license shall include provisions which insure that the research tool will be available to the academic research community on reasonable terms.”

 “Provider agrees that Recipient shall have the right to make any materials and inventions developed by Recipient
in the course of the collaboration (including materials and inventions developed jointly with Provider, but not including any Provider materials (or parts thereof) or Provider sole inventions available to other scientists at not-for-profit
organizations for use in research, subject to Provider’s independent intellectual property rights.” 
 “Subject to Recipient’s obligations to the U.S. government, including 37 CFR Part 401, the NIH Grants Policy Statement, and the NIH Guidelines for Obtaining and Disseminating Biomedical Research Resources, Recipient grants to
Sponsor the following rights:...” 
 Grantbacks and Option Rights 
  

	 	•	 	 Agreements to acquire materials from for-profit entities for use in NIH-funded research may provide a grant back of non-exclusive, royalty-free rights
to the provider to use improvements and new uses of the material that, if patented, would infringe any patent claims held by the provider. They may also provide an option for an exclusive or non-exclusive commercialization license to new inventions
arising directly from use of the material. These should be limited to circumstances where the material sought to be acquired is unique, such as a patented proprietary material, and not reasonably available from any other source. A non-exclusive
“grant-back” might be used, for example, to protect a for-profit entity that provides a proprietary compound from being blocked from using new uses or improvements of that compound discovered during the NIH-funded project. In providing
license options, Recipients must ensure that licenses granted to providers under such options are consistent with Bayh-Dole requirements, including the preference for U.S. industry requirements and reservation of government rights under 37 C.F.R.
Part 401. 

  

	 	•	 	 In determining the scope of license or option rights that are granted in advance to a provider of materials, Recipient should balance the relative
value of the provider’s contribution against the value of the rights granted, cost of the research, and importance of the research results. The rights granted to providers should be limited to inventions that have been made directly through the
use of the materials provided. In addition, Recipients should reserve the right to negotiate license terms that will ensure: 1) continuing availability to the research community if the new invention is a unique research resource;

  

 42 

	 	 
2) that the provider has the technical and financial capability and commitment to bring all potential applications to the marketplace in a timely manner; and 3) that if an exclusive license is
granted, the provider will provide a commercial development plan and agree to benchmarks and milestones for any fields of use granted. 

  

	 	•	 	 It is expected that agreements to acquire NIH-funded materials from not-for-profit entities for use in NIH-funded research will not include
commercialization option rights, royalty reach-through, or product reach-through rights back to the provider. Such materials should be acquired under the Simple Letter Agreement or UBMTA, or, if the materials are patented, a simple license agreement
that does not request reach-through to either future products or royalties. If the providing not-for-profit organization is constrained in sharing the material due to a pre-existing sponsored research agreement or license, NIH expects the
not-for-profit provider to negotiate a suitable resolution with the private research sponsor or licensee. The co-mingling of NIH and sponsored research funds is allowed, however, Recipient is responsible for ensuring that conditions on the use of
the sponsored funds do not interfere with the open dissemination of research tools. 

 December 1999 

 

 43 

 FIRST AMENDMENT TO THE EXCLUSIVE LICENSE AGREEMENT BY AND 
 BETWEEN DANA-FARBER CANCER INSTITUTE AND GENPATH 
 PHARMACEUTICALS, INC 
 This First Amendment (the “Amendment”) effective
as of the last date set forth on the signature page hereof by and between Dana-Farber Cancer Institute (DFCI) and GenPath Pharmaceuticals, Inc. (Licensee) amends the EXCLUSIVE LICENSE AGREEMENT by and between DFCI and Licensee dated March 19th,
2002 (the “Agreement”). DFCI and Licensee are sometimes referred to herein individually as a party and collectively as the parties. 
 WHEREAS, the parties wish to amend certain provisions of the Agreement to allow Licensee to assume responsibility for prosecution of Patent Rights (as defined in the Agreement). 
 NOW, THEREFORE, in consideration of the mutual promises and undertakings contained herein, the parties agree as follows: 
 1. Unless otherwise defined herein, capitalized terms herein shall have the same meanings as set forth in the Agreement. 
 2. Article 6 and Article 7 of the Agreement shall be amended and restated in its entirety. 
 3. Except as specifically amended hereby, the Agreement shall remain unchanged and in full force. 
 Article 6 Patent Preparation, Filing, Prosecution and Maintenance 
 Prosecution by
Licensee. 
  

	6.1	Responsibility. Licensee is responsible for preparing, filing, prosecuting and maintaining the patent applications and patents included within Patent Rights and
for paying all associated costs. For purposes of this Agreement, patent prosecution includes ex parte prosecution, interference proceedings, reissues, reexaminations and oppositions. Licensee shall provide, or cause its agent to provide, copies of
relevant correspondence between Licensee and the United States Patent Office or the various foreign patent offices and give DFCI reasonable opportunity to advise Licensee or Licensee’s counsel on such matters. DFCI designates the following
individual or department for receiving the patent-related correspondence. 

 Patent Counsel 
 Office of Patent Counsel 
 Dana-Farber Cancer Institute 
 44 Binney St. 
 Boston, MA 02115 
 Upon DFCI’s request, Licensee shall be available to consult with DFCI on matters relating to preparing, filing, prosecuting or maintaining any of the applications or patents within Patent Rights. Licensee shall consider the legitimate
interests of DFCI as owner of the Patent Rights in performing its responsibility under this Section 6.1. Licensee designates the following individual or department to receive such requests from DFCI. 
  

 1 

 Fish & Neave 
 1251 Avenue of the Americas 
 New York, New York 10020 
  

	6.2	Cooperation. DFCI shall cooperate with Licensee in preparing, filing, prosecuting and maintaining the patent applications and patents within Patent Rights. The
parties shall provide prompt notice to each other of any matter that comes to their attention that may affect the patentability, validity or enforceability of any patent application or patent within Patent Rights. 

  

	6.3	Relinquishing Rights. If licensee elects not to prepare, prosecute, and/or maintain any patents or patent applications in any country(ies) or region(s) in the
world Licensee shall give DFCI [**] days advance written notice; relinquish responsibility for prosecution of said non-elected application or patent; and surrender its license under such non-elected patent application or patent. However, if Licensee
is surrendering any patent or application within Patent Rights on which an interference proceeding or opposition has been declared or filed, the notice period is [**] days. If Licensee so surrenders its rights, it will remain responsible for all
patent-related expenses incurred during the applicable notice period. Thereafter, Licensee will have no further obligation to pay any patent expenses for the patents or patent applications that it surrendered. 

  

	6.4	Prosecution By DFCI 

 Upon
Licensee relinquishing responsibility for prosecution and surrendering its license pursuant to Section 6.3, DFCI shall thereafter have the right, but not any obligation, to prosecute, obtain issuance of, and/or maintain such Patent Rights
relinquished by Licensee in such country(ies) or region(s) at its own cost, and any such applications and resultant patents shall not be subject to this Agreement. 
 Article 7 – Patent Infringement and Enforcement 
  

	7.1	Notice. If at any time during the term of this Agreement, Licensee becomes aware of an apparent infringement in a particular country of a patent within Patent
Rights, it must promptly notify DFCI whether or not it chooses to take action against the alleged infringer. 

  

	7.2	Action by Licensee. 

  

	 	7.2.1	 Licensee shall have the first right, but not the obligation, for enforcing the Patent Rights and prosecuting apparent infringers at its expense
and in its own name when, in its judgment, such action may be reasonably necessary and justified. Before Licensee commences any legal proceeding with respect to the infringement, Licensee shall consider in good faith the views of DFCI. If Licensee
notifies DFCI that it intends to prosecute the alleged infringer, then Licensee

  

 2 

	 	 
has six (6) months from the date of its notice to DFCI to either (a) cause the infringement to terminate or (b) initiate legal proceedings against the infringer. If any such suit
is brought by Licensee in its own name it will be at Licensee’s expense and on its own behalf. Licensee has the right to join DFCI as a party-plaintiff if required by law, at Licensee’s expense. 

  

	 	7.2.2	Action at Request of DFCI. DFCI may request Licensee to take steps to protect the Patent Rights from an apparent infringement. Licensee shall notify DFCI, within
three (3) months of receiving a written request from DFCI, of action it intends to take, if any, to compel termination of the alleged infringing action or to initiate legal proceedings against the alleged infringer. 

  

	 	7.2.3	DFCI Right to join. DFCI independently has the right to join any legal proceeding brought by Licensee under this Section 7.2 and fund up to fifty percent of
the cost of the legal proceeding from the date of joining. If DFCI elects to join as a party plaintiff pursuant to this paragraph 7.2.3, DFCI may jointly participate in the action with Licensee, but Licensee’s counsel will be lead counsel.

  

	 	7.2.4	Settlement. In any legal proceeding initiated by Licensee, no settlement, consent judgment or other voluntary final disposition of the legal proceeding that
adversely affects DFCI may be entered into without the consent of DFCI, which consent shall not be unreasonably withheld. 

  

	7.3	Action by DFCI. 

  

	 	7.3.1	Procedure. If Licensee notifies DFCI that it does not intend to prosecute an infringement or, if Licensee fails to cause the infringement to terminate or
initiate legal proceeding to compel termination within six (6) months of the date of its notice to DFCI pursuant to paragraph 7.2.1, above, then DFCI may initiate legal proceedings against the alleged infringer, at DFCI’s expense and on
its own behalf according to the terms of this Section 7.3. Before DFCI commences any legal proceeding with respect to the infringement, DFCI shall consider in good faith the views of Licensee. DFCI has the right to join Licensee as a
party-plaintiff if required by law, at DFCI’s expense. 

  

	 	7.3.2	Licensee’s Right To Join. Licensee independently has the right to join any legal proceeding brought by DFCI under this Section 7.3 and fund up to fifty
percent of the cost of the legal proceeding from the date of joining. If Licensee elects to join as a party plaintiff pursuant to this paragraph 7.3, Licensee may jointly participate in the action with DFCI, but DFCI’s counsel will be lead
counsel. 

  

	 	7.3.3	Settlement. Regardless of whether Licensee is joined or joins any legal proceeding initiated by DFCI, no settlement, consent judgment or other voluntary final
disposition of the legal proceeding may be entered into without the consent of DFCI, which consent shall not be unreasonably withheld. 

  

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	7.4	Cooperation. If one party initiates legal proceedings to enforce the Patent Rights pursuant to this Article 7, the other party shall cooperate with and supply
all assistance reasonably requested by the party initiating the proceedings, at the initiating party’s request and expense. 

  

	7.5	Distribution of Amounts Paid by Third Parties in Connection with Legal Proceedings. In any legal proceeding brought by Licensee under Section 7.2 and funded
solely by Licensee, (1) Licensee shall first recover from any damages or other amounts recovered as a result of the proceeding, its out of pocket expenses in pursuit of such legal proceeding, (2) DFCI shall second recover a sum equivalent
to the total amount of royalties and sublicense or partnering income royalties deducted by Licensee under Section 7.5.1 if any and (3) Licensee shall third recover an amount equal to its lost profits or a reasonable royalty (whichever
measure of damages has been applied in the legal proceeding or settlement thereof). DFCI shall then receive the amount of royalties that Licensee would have owed to DFCI under paragraphs 3.16 and 3.17 of the Agreement if Licensee had made the
infringer’s sales directly (“Lost Royalty”), the amount of such royalties not to exceed the amount of any lost profits or reasonable royalty (whichever measure of damages has been applied in the legal proceeding or settlement thereof)
award. The balance remaining, if any, will be divided equally between DFCI and Licensee. In any legal proceeding brought by DFCI under Section 7.3 and funded solely by DFCI, DFCI shall first recover its out of pocket expenses in pursuit of such
legal proceeding as well as an amount equal to its Lost Royalty. Licensee shall then receive an amount equal to its lost profits or a reasonable royalty (whichever measure of damages has been applied in the legal proceeding or settlement thereof)
less the amount of DFCI’s Lost Royalty. The balance remaining, if any, will be divided equally between DFCI and Licensee. If the legal proceeding was funded jointly by the parties, each party will first be reimbursed for its out of pocket
expenses in pursuit of such legal proceeding. The balance, if any, will be divided between the parties according to their respective percentage contributions to the total documented cost and expenses of the legal proceeding, including each
party’s reasonable attorney fees. 

  

	 	7.5.1	Reduction of Royalties. In the event of a legal proceeding under Section 7.2.2 and if DFCI does not independently join such legal proceeding, Licensee may
deduct up to [**] percent ([**]%) of Licensee’s documented and unreimbursed costs and expenses (including reasonable attorney fees) incurred in a legal proceeding under this Article from running royalties payable to DFCI under paragraphs 3.1.6
and 3.1.7 of this Agreement from sales of Licensed Products covered by the patent(s)-in suit or sublicense or partnering income relating to the patent(s)-in suit. However, Licensee may not reduce DFCI’s royalty payments based upon the patent in
suit by more than [**] percent ([**]%) of the amount otherwise due under Article 3. If [**] percent ([**]%) of Licensee’s costs and expenses exceed the amount of royalties deducted by Licensee for any calendar year, Licensee may, to that
extent, reduce the royalties due to DFCI in succeeding calendar quarters. However, Licensee may not reduce total royalties due to DFCI based upon the patent in suit in a given calendar quarter by more than [**] percent ([**]%).

  

 4 

	7.6	Declaratory Judgment Actions. In the event that any third party initiates a declaratory judgment action alleging the invalidity or unenforceability of the Patent
Rights, or if any third party brings an infringement action against Licensee or its Affiliates or Sublicensees because of the exercise of the rights granted Licensee under this Agreement, then Licensee shall have the right to defend such action
under its own control and at its own expense; provided, however, that DFCI shall have the right to intervene and participate jointly of such defense. In the case of such participation, DFCI will fund up to [**] percent ([**]%) of the cost of the
defense from the date of its joining. Licensee shall NOT enter into any settlement, consent judgment or other voluntary final disposition of any action under this Section 7.6 that adversely affects DFCI without the consent of DFCI, which
consent shall not be unreasonably withheld, unless, the settlement includes any express or implied admission of liability or wrongdoing on DFCI’s part, in which case DFCI’s right to grant or deny consent is absolute and at its sole
discretion. Any recovery shall be first applied to reimburse each party pro rata for any out-of pocket expenses it may have incurred with respect to defense of such action and the remainder shall be retained entirely by the party controlling the
action; provided however that any recovery for infringement will be distributed as described in Section 7.5. 

 (Signature page follows) 
  

 5 

 IN WITNESS WHEREOF, the Parties have hereto affixed their authorized signatures. 
  

									
	GenPath Pharmaceuticals, InC. (Licensee)	 		 	Dana-Farber Cancer Institute (DFCI)
					
	Date:	 	 /s/ Tuan Ha-Ngoc
	 		 	By:	 	 /s/ Anthony A. del Campo

		 	Tuan Ha-Ngog	 		 		 	Anthony A. del Campo, MBA
					
	Title:	 	President & CEO	 		 	Title:	 	Vice President, Office of Research and Technology Ventures
					
	Date:	 	 7/22/2003
	 		 	Date:	 	 7/21/2003

  

 6 

 SECOND AMENDMENT TO THE EXCLUSIVE LICENSE AGREEMENT BY AND 
 BETWEEN DANA-FARBER CANCER INSTITUTE AND GENPATH 
 PHARMACEUTICALS, INC 
 This Second Amendment is effective
January 1st, 2003 is between Dana-Farber Cancer Institute (DFCI) and GenPath Pharmaceuticals, InC. (Licensee) amends the EXCLUSIVE LICENSE AGREEMENT by and between DFCI and Licensee dated March 19th, 2002 (the “Agreement”). DFCI and Licensee are sometimes
referred to herein individually as a Party and collectively as the Parties. 
 WHEREAS, the Parties wish to amend the Agreement
to include certain additional biological materials under the terms of the Agreement. 
 NOW, THEREFORE, in consideration of the
mutual promises and undertakings contained herein, the Parties agree as follows: 
  

	1.	Unless otherwise defined herein, capitalized terms herein shall have the same meanings as set forth in the Agreement. 

  

	2.	The biological materials specified in Exhibit A (the “DFCI Materials”) from the laboratory of Dr. Lynda Chin shall be included under the term
“Biological Materials” as defined in the Agreement. 

  

	3.	Licensee shall retain control over the DFCI Materials and shall not transfer the DFCI Materials to any third party without prior written approval of the DFCI.

  

	4.	No Warranty: THE DFCI MATERIALS ARE SUPPLIED TO LICENSEE WITH NO WARRANTIES, EXPRESS OR IMPLIED, AND THE DFCI EXPRESSLY DISCLAIMS ANY WARRANTY OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR NONINFRINGEMENT. 

  

	5.	Licensee acknowledges that the DFCI Materials are experimental in nature and may have unknown characteristics and therefore agrees to use prudence and reasonable care
in the use, handling, storage, transportation and disposition and containment of the DFCI Materials and all derivatives thereof. 

  

	6.	Licensee shall use the DFCI Materials in compliance with all applicable laws and shall not use the DFCI Materials in research on humans. 

  

	7.	Except as specifically amended hereby, the Agreement shall remain unchanged and in full force. 

 (Signature Page to Follow) 
  

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 IN WITNESS THEREOF, the parties have caused this Agreement to be executed below. 
  

									
	Dana-Farber Cancer Institute (DFCI)	 		 	GenPath Pharmaceuticals, Inc. (Licensee)
					
	By:	 	 /s/ Anthony del Campo
	 		 	By:	 	 /s/ Elan Ezickson

		 	(Signature)	 		 		 	(Signature)
		 	Anthony del Campo	 		 		 	Elan Ezickson
		 	Technology Ventures	 		 		 	Chief Business officer
			
	 9/29/03
	 		 	 10/2/03

	(Date)	 		 	(Date)
				
	Read and Understood:	 		 		 	
				
	 /s/ Lynda Chin
	 		 		 	
	(Signature)	 		 		 	
	Lynda Chin, MD	 		 		 	
	Assistance Professor of Medicine,	 		 		 	
	Dana-Farber Cancer Institute	 		 		 	
				
	 10/1/03
	 		 		 	

  

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 DFCI Agreement No. 1444 
 EXHIBIT A 
 DFCI MATERIALS

 [**] 
  

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