Document:

EX-10.3

 Exhibit 10.3 

BIOTIE THERAPIES CORP. 
 EQUITY INCENTIVE plan 2014
(the 2014 Equity Plan) 
 The Board of Directors of Biotie Therapies Corp. (the Board) has at its meeting on 2 January 2014 resolved,
by authorization of the Annual General Meeting of Shareholders of Biotie Therapies Corp. (the Company, or together with its subsidiaries the Group) on 4 April 2013, to implement an equity incentive plan on the following terms and
conditions: 
 GENERAL TERMS AND CONDITIONS OF THE 2014 EQUITY PLAN 

1. Objectives of the 2014 Equity Plan 
 The 2014 Equity
Plan is designed to form part of the remuneration, incentive and commitment program for the employees of the Group and thus the Company has a particularly weighty financial reason for the issue of awards pursuant to the 2014 Equity Plan. The aim is
to align the objectives of the shareholders and employees in order to increase the value of the Company, to commit employees to the Company, and to offer them a competitive incentive plan based on holding the Company’s shares (Shares) or
equivalent instruments. 
 2. Target Group 
 Each year
the Board shall determine, in its absolute discretion, the Group employees that shall receive an award, or awards, pursuant to the 2014 Equity Plan (Employee, jointly Employees). Selected Employees must be employed by, or in the
service of, a company belonging to the Group (Group Company) at the time an award is granted. However, the Board may pre-approve maximum awards for Employees that are expected to join the Group during the Discretionary Period in advance of
them joining and allow the CEO to determine the level of the final award, subject to the maximum pre-approved award, when the Employee joins the Group. 

Receiving an award pursuant to the 2014 Equity Plan shall not affect other employment or service terms. The 2014 Equity Plan and any awards made under it
shall be fully discretionary. 
 In addition, certain of the awards are only for issue to the Chief Executive Officer, Chief Operating Officer, Chief
Medical Officer, Chief Financial Officer and by exception any other employee that the Board agrees at its sole discretion (together, the Senior Management) only. These awards will be identified (as detailed in Section 3 and 4 below) and
are subject to additional criteria as outlined in Exhibit A (Senior Management Shares). However, each member of Senior Management can only receive such units under either the 2014 Option Plan or the 2014 Equity Plan and not both. 

When deciding upon the quantum of any award the Board may take into consideration the duration of employment or service of the Employee concerned and such
other factors as may be determined by the Board, including their expected contribution to the Group in future years. 

 The awards shall be issued at no cost to the Employees, but the share subscription based on the awards is subject
to payment set forth in Section 6 below. 
 3. Share Reserve 

The number of Shares subject to awards pursuant to the 2014 Equity Plan and the number of corresponding Shares to be subscribed on the basis of the entire 2014
Equity Plan shall be a maximum total of 14,002,500 Shares, of which 2,520,000 shall be designated Senior Management Shares (as per Section 2 above). The Shares subscribed may either be new Shares in the Company or existing Shares held by the
Company. In the event an award is forfeited or otherwise cancelled without the delivery of Shares to an Employee, the Shares subject to such award shall again be available to be made subject to an award pursuant to the 2014 Equity Plan. 

4. Form of Share Awards 
 The 2014 Equity Plan offers
Employees the possibility to receive the Company’s share units (Share Unit), whereby the Employee shall subscribe a Share for each Share Unit awarded to the Employee; the Share Units which are in relation to the Senior Management Shares
are to be termed Senior Management Share Units and are, by definition, a subset of the Share Units. The maximum total number of Share Units is 14,002,500, of which 2,520,000 shall be designated Senior Management. The terms and conditions of
such Share Units shall be determined by the Board in its sole discretion. The terms and conditions for the Share Units shall include the terms and conditions in Exhibit A. For the avoidance of doubt, the Share Units require the Employee to subscribe
for the relevant Shares in question and the Employee hereby gives by accepting any Share Units his/her irrevocable authorization for the Company to subscribe, pay and deliver the Shares allocated to him/her pursuant to this 2014 Equity Plan. 

5. Subscription Period 
 The subscription periods for
share subscription are determined in Exhibit A (Subscription Period). 
 6. Share Subscription Price 

Each Share Unit entitles its owner to subscribe for one (1) new Share in the Company or an existing Share held by the Company. The share subscription
price shall be credited to the reserve for invested unrestricted equity. 
 The share subscription price shall, for all Share Units, be USD 0.01 per
share (Subscription Price). The Employees who have been granted Share Units hereby give their irrevocable approval to the Company to deduct the entire share subscription price needed to subscribe Shares based on Share Units from
Employees’ paycheck. 

  
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 7. Shareholder Rights 

The shareholder rights to the subscribed Shares shall be assigned to an Employee on the date when the Shares are registered on the book-entry account of an
Employee. If the Shares to be subscribed are new, the shareholder rights shall arise from the registration of the Shares with the Finnish Trade Register. 

8. Adjustments in Certain Special Cases 
 8.1.
Distribution of Assets 
 Should the Company, differing from the Company’s normal practice, distribute dividends or similar assets from reserves of
unrestricted equity, after 2 January 2014 but before share subscription, the Board may decide on the adjustment of the number of Shares available for subscription so that the position of the Share Unit owner corresponds to that of a
shareholder, as per the dividend record date or the record date of the repayment of equity. 
 Should the Company reduce its share capital by distributing
share capital to the shareholders, or reduce its share premium fund by distributing funds from the share premium fund to the shareholders, after 2 January 2014 but before share subscription, the Board may decide on the adjustment of the number
of Shares available for subscription so that the position of the Share Unit owner corresponds to that of a shareholder, as per the record date of the repayment of share capital. 

8.2. Issue of Shares, Stock Options or Other Special Rights entitling to Shares 

Should the Company, before the share subscription, decide on an issue of Shares or an issue of stock options or other special rights entitling to Shares, so
that the shareholders have pre-emptive right to subscription, a Share Unit owner shall have the same right as, or an equal right to, that of a shareholder. Equality is reached in the manner determined by the Board by adjusting the number of Shares
available for subscription. 
 8.3. Liquidation or deregistration of the Company 

Should the Company be placed in liquidation before the share subscription, the Share Unit owner shall be given an opportunity to exercise his or her share
subscription right, within a period of time determined by the Board. Should the Company be deregistered, before the share subscription, the Share Unit owner shall have the same right as, or an equal right to, that of a shareholder. In this case the
2014 Equity Plan shall expire. 
 8.4. Merger, Demerger or Transfer of Domicile 

Should the Company resolve to merge with another company as a merging company or merge with a company to be formed in a combination merger, or should the
Company resolve to be demerged entirely, the Share Unit owners may, prior to the registration of the execution of a merger or a demerger, be given the right to subscribe for Shares with their Share Units, in a manner and within a period of time
determined by the Board. 

  
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Alternatively, the Board may give a Share Unit owner the right to convert the Share Units into stock options or other special rights entitling to shares issued by the other company, in the manner
determined in the draft terms of merger or demerger, or in the manner otherwise determined by the Board, or the right to sell Share Units prior to the registration of the execution of a merger or a demerger. After such period, no share subscription
right or conversion right shall exist. The same proceeding shall apply to cross-border mergers or demergers, or should the Company, after having registered itself as an European Company (Societas Europae), or otherwise, register a transfer of its
domicile from Finland into another member state of the European Economic Area. The Board shall decide on the impact of potential partial demerger on the Share Units. In the above situations, the Share Unit owners shall have no right to require that
the Company redeem the Share Units from them at their market value. 
 8.5. Redemption Right and Obligation 

Should a redemption right and obligation in relation to all of the Company’s Shares, as referred to in Chapter 18 Section 1 of the Finnish Limited
Liability Companies Act, arise to any of the shareholders, during the Subscription Period in question, on the basis that a shareholder possesses over 90 per cent of the Shares and the votes of the Company, the Share Unit owners shall be given
the opportunity to exercise their right of share subscription by virtue of the Share Units, within a period of time determined by the Board, or the Share Unit owners shall have an equal obligation to that of shareholders to transfer their Share
Units to the redeemer. 
 Should a redemption right or obligation arise before the Subscription Period in question, the Share Unit recipient may be granted
the right to Subscribe Shares based on the Share Units as may be determined by the Board in its sole discretion upon arising of the redemption right and obligation and then given the same opportunities as outlined in the previous paragraph and the
proceedings shall be the same as above. In these cases, the 2014 Equity Plan shall expire. 
 8.6. Acquisition or Redemption of Treasury Shares, Stock
Options and Other Special Rights entitling to Shares 
 Acquisition or redemption of the Company’s treasury shares or acquisition of stock options
or other special rights entitling to shares shall have no impact on the rights of the Share Unit owner. Should the Company, however, resolve to acquire or redeem its treasury shares from all shareholders, the Share Unit owners shall be made an
equivalent offer or an equivalent adjustment to the number of Share Units shall be made. 
 9. Incorporation of Share Units into the Book-entry
Securities System 
 The Board may decide to incorporate the Share Units into the book-entry securities system. Should the Share Units be incorporated
into the book-entry securities system, the Company shall have the right to request and get transferred all forfeited Share Units from the Share Unit owner’s book-entry account to the book-entry account nominated by the Company, without the
consent of the Share Unit owner. In addition, the Company shall be entitled to register transfer restrictions and other restrictions concerning the Share Units on the Share Unit owner’s book-entry account, without the consent of the Share Unit
owner. 

  
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 10. Administration of the 2014 Equity Plan 

The Board shall manage the 2014 Equity Plan and decide on all matters relating thereto. The decision of the Board on any matters relating to the 2014 Equity
Plan shall be final and binding on all parties. 
 The Board may delegate certain matters relating to the 2014 Equity Plan to individuals within the Company
as it sees fit. 
 Should an Employee act against these terms and conditions, or against the instructions given by the Company, on the basis of these terms
and conditions, or against applicable law, or against the regulations of the authorities, the Company shall be entitled to withdraw, without paying any compensation, an award which has not been transferred, or with which Shares have not been
subscribed for, from the Employee. 
 The Company may maintain a register of the Employees on which the Employees’ personal data is recorded. An
Employee accepts that the data shall be administered and processed by the Company or any other agent or person designated by the Company. An Employee is entitled to request access to the data referring to him or her and held by the Company. The
Company may send all announcements regarding the 2014 Equity Plan to the Employees by e-mail. 
 11. Amendment and Interpretation of the Terms and
Conditions of the 2014 Equity Plan 
 The Board shall be entitled to interpret the terms and conditions of the 2014 Equity Plan. 

The Board may, at any time, amend the terms and conditions of the 2014 Equity Plan or any award pursuant to the 2014 Equity Plan; provided, however, that,
without the written consent of the Employee(s) affected, the terms and conditions shall be amended in such a manner that no considerable defect or material detriment shall occur to any Employee with respect to an outstanding award, as a result of
amending the terms and conditions of the 2014 Equity Plan or the award. 
 The 2014 Equity Plan shall expire on the earlier of (i) the issuance
pursuant to the 2014 Equity Plan of the maximum number of Shares permitted by Section 3 or (ii) the termination of the 2014 Equity Plan by the Board when no awards pursuant to the 2014 Equity Plan are outstanding. 

12. Applicable Law and Settlement of Disputes 
 These
terms and conditions shall be construed in accordance with and governed by the laws of Finland. All disputes arising out of or in connection with this 2014 Equity Plan shall be exclusively submitted to arbitration, in accordance with the Arbitration
Rules of 

  
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 the Finland Chamber of Commerce. The place of arbitration shall be either (i) Helsinki, Finland or
(ii) San Francisco, California as determined by the Employee. The language of the arbitration proceedings shall be English and the arbitral tribunal shall consist of one (1) arbitrator, who shall be appointed by the Arbitration Institute
of the Finland Chamber of Commerce. 
 These terms and conditions have been prepared in Finnish and in English. In the case of any discrepancy between the
Finnish and English versions, the English shall prevail. 
 EXHIBIT A 

TERMS AND CONDITIONS OF 2014-2016 SHARE UNIT AWARDS 
 Share
Unit awards in 2014 through 2016 shall be subject to the terms and conditions of the 2014 Equity Plan and the following terms and conditions: 
 1.
Discretionary Periods and Share Units 
 The 2014 Equity Plan offers Employees the possibility of receiving the Company’s Share Units during three
(3) consecutive discretionary periods, calendar years 2014, 2015 and 2016 (each separately, Discretionary Period). If the Company’s financial year changes from being based on calendar years, before the end of a Discretionary Period,
the Board shall be entitled to change a Discretionary Period accordingly. 
 Each year the Board shall determine the number of Share Units granted to each
Employee and Employees shall be notified of the number of Share Units that have been granted as soon as reasonably possible after the decision by the Board. 

In addition as outlined in Section 2, the Board at its sole discretion will determine awards to Senior Management that are subject to additional
restrictions as outlined in this Exhibit A; only one such award may be made to each member of Senior Management and it will be made in Discretionary Period 2014. The amount will be determined by considering the total amount of awards to be made to
each member of Senior Management in Discretionary Period 2014; 40% of these awards multiplied by three (3) will be designated as Senior Management Share Units; the remaining 60% will be under the same rules as other Employees for awards made in
Discretionary Period 2014. The total amount of award for each member of Senior Management made in each of Discretionary Periods 2015 and 2016 will be reduced by one third of the Senior Management Share Units awarded in Discretionary Period 2014.
These Senior Management Share Units will be subject to a multiplier, as detailed in Section 3 of Exhibit A below, which will then determine the amount of Shares that are awarded to each member of Senior Management. 

As an example and for the avoidance of doubt, if a member of Senior Management were to be made a total award of 300,000 Share Units in the Discretionary
Period 2014, then 180,000 Share Units (being 60% of 300,000) would have the same conditions as all Employees and 360,000 (being 40% of 300,000 multiplied by 3) will be termed Senior Management Share Units and be subject to the multiplier. Then the
total awards made for Discretionary Periods 2015 and 2016 will be reduced by 120,000 Share Units (being one third of the 360,000 Senior Management Share Units) and will have the same conditions as for all Employees. 

  
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 Share Units may only be granted to Employees who are employed by or in the service of a Group Company on the
grant date. However, as noted in the General Terms and Conditions of the 2014 Equity Plan, Section 2, the Board may pre-approve awards for future joiners with the final decision being determined by the CEO. 

2. Subscription Periods 
 For Senior Management Share
Units issued in the Discretionary Period 2014 (Tranche M), the Subscription Period is 5 January 2017 until 31 January 2017, so that the Shares in question will, to the extent the preconditions for share subscription are fulfilled, be
issued and delivered during January and February 2017, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2018. 

For all remaining Share Units, each Discretionary Period is followed by two (2) separate Subscription Periods during which Shares may be subscribed: 

 

	 	•	 	For the Discretionary Period comprising calendar year 2014, the Subscription Periods are as follows: 

  

	 	•	 	For 25% of the Share Units awarded to each Employee (Tranche A), the Subscription Period is 5 January 2016 until 31 January 2016, so that the Shares in question will be issued and delivered during January and
February 2016, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2017; and 

  

	 	•	 	For the remaining Share Units awarded to each Employee (Tranche B), the Subscription Period is 5 January 2017 until 31 January 2017, so that the Shares in question will be issued and delivered during January
and February 2017, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2018. 

  

	 	•	 	For the Discretionary Period comprising calendar year 2015, the Subscription Periods are as follows: 

  

	 	•	 	For 25% of the Share Units awarded to each Employee (Tranche C), the Subscription Period is 5 January 2017 until 31 January 2017, so that the Shares in question will be issued and delivered during January and
February 2017, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2018; and 

  

	 	•	 	For the remaining Share Units awarded to each Employee (Tranche D), the Subscription Period is 5 January 2018 until 31 January 2018, so that the Shares in question will be issued and delivered during January
and February 2018, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2019. 

  
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	 	•	 	For the Discretionary Period comprising calendar year 2016, the Subscription Periods are as follows: 

  

	 	•	 	For 25% of the Share Units awarded to each Employee (Tranche E), the Subscription Period is 5 January 2018 until 31 January 2018, so that the Shares in question will be issued and delivered during January and
February 2018, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2019; and 

  

	 	•	 	For the remaining Share Units awarded to each Employee (Tranche F), the Subscription Period is 5 January 2019 until 31 January 2019, so that the Shares in question will be issued and delivered during January
and February 2019, unless restricted by Section 4 below, in which case the Shares shall be delivered no later than 15 March 2020. 

In case of fractional Share Units or Shares, the number shall be rounded downwards to a closest full number for the initial 25% of the Share Units. The
remainder of the total award will then be included as the subsequent 75% of the Share Units. 
 Should the last day of the Subscription Period not be a
banking day, the share subscription may be made on a banking day following the last share subscription day. 
 The Employees shall pay the Subscription
Price, as detailed in Section 6 above, prior to the obligation of the Company to deliver the Shares. The Employees who have been granted Share Units hereby give their irrevocable approval to the Company to deduct the entire share subscription
price needed to subscribe Shares based on Share Units from Employees’ paycheck. For the avoidance of doubt, the Share Units require the Employee to subscribe for the relevant Shares in question and the Employee hereby gives by accepting any
Share Units his/her irrevocable authorization for the Company to subscribe, pay and deliver the Shares allocated to him/her pursuant to this 2014 Equity Plan. 

The Board shall decide on all measures concerning the share subscription. 

In each case, after which the Company’s Shares shall be delivered to Employees on the basis of the granted Share Units. In the 2014 Equity Plan, one
(1) Share Unit corresponds to one (1) Share. 
 3. Multiplier for Senior Management Share Units 

As noted in Section 2, the Senior Management Share Units will be subject to a multiplier (Multiplier) to determine the amount of Share Units that
will be issued for each recipient of Senior Management Share Units. The Multiplier will be determined on the percentage growth in the share price from 1 January 2014 to 31 December 2016 (Share Price Growth). The share price on each
of 1 January 2014 and 31 December 2016 will be determined by the trade volume weighted average quotation of the Share on NASDAQ OMX Helsinki Ltd. for the preceding 30 days. 

  
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 The Multiplier will be calculated as follows: 

 

	 	•	 	For Share Price Growth of less than 35%, the Multiplier will be nil (0.0) times the Senior Management Share Units; and 

  

	 	•	 	For Share Price Growth of between 35% and 100%, the Multiplier will be a straight line increase from nil (0.0) times the Senior Management Share Units at 35% to three (3.0) times the Senior Management Share Units
at 100%. This means that for each extra 1% of Share Price Growth between 35% and 100% the multiplier will increase by 0.046 times; the Multiplier will be rounded to two decimal points; and 

 

	 	•	 	For Share Price Growth of greater than 100% the Multiplier will be a flat three (3.0) times the Senior Management Share Units. 

The result of applying the Multiplier to the Senior Management Share Units will then be equal to the Shares that are eligible for each member of Senior
Management and subject to the Terms and Conditions in this Exhibit A. 
 4. Share Delivery 

 

	 	i.	The Shares shall be delivered to Employees after each Subscription Period on a date set by the Board during January and February immediately following the end of each Subscription Period. 

 

	 	ii.	The right to Shares is personal, and they shall only be delivered to an Employee, or a former employee. The right to Shares may not be assigned or otherwise transferred. Upon death, the Shares shall be delivered to the
estate or beneficiary or heir of an Employee. An Employee (or his or her estate, beneficiary or heir, as the case may be) shall be liable for all taxes and tax-related consequences arising to him, her or it from an award pursuant to the 2014 Equity
Plan. The Company may require the Employee (or his or her estate, beneficiary or heir, as the case may be) to make adequate provision for any withholding obligation of the Company as a condition of any Share delivery pursuant to the 2014 Equity
Plan. 

  

	 	iii.	Should (a) the date of Share delivery occur during a blackout period of the Company or while the Employee has insider status and (b) the Employee has not made an advance plan to sell shares, the Share delivery
shall be automatically postponed until after the end of the blackout period or expiry of the possession of insider information; provided, however, that in no event shall the Shares be delivered later than the 15 March of the calendar year
following the calendar year in which the Subscription Period in question began. 

  

	 	iv.	 The Board shall have the right, in its absolute discretion, to reduce, including for the avoidance of doubt to zero, the number of Shares to be
delivered, or to postpone the Share delivery to a later date that better suits the Company, if 

  
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changes that are beyond the Company’s control, such as legal, fiscal, economic or business related factors, might lead to an extremely harmful or extremely unreasonable outcome for the
Company. However, in no event shall the Shares be delivered later than the 15 March of the calendar year following the calendar year in which the Subscription Period in question began. 

 

	 	v.	The Board shall have the right to cancel the Share delivery, in full or in part, if the Group’s financial statements have to be amended and those amendments affect the number of Shares to be delivered, or if an
Employee has, in the reasonable opinion of the Board, committed a serious criminal offence, broken any ethical code of which he has been notified by the Company or has otherwise acted in a way which the Board reasonably thinks might damage the
reputation of the Company. 

 5. Preconditions before Subscription Period 

 

	 	a.	Except as provided in Section 5(b), should an Employee’s employment or service in a Group Company end before the commencement of a Subscription Period (Normal Vesting Date), the Share Units held by the
Employee associated with such Subscription Period shall gratuitously be forfeited to the Company or its designate. However, the Board may, in its absolute discretion, in these cases decide that an Employee is entitled to keep the Share Units or a
part of them. 

  

	 	b.	Should an Employee become permanently disabled, retire statutorily or as determined by the Company, or die, before the Subscription Period with the Share Units in questions has started, an Employee or his or her estate
or beneficiary or heir shall be entitled to keep the granted Share Units. 

 Should an Employee’s employment or service in a Group
Company end due to a corporate arrangement or transfer of business, before the Subscription Period with the Share Units in question has started, an Employee shall be entitled to keep the granted Share Units. 

An Employee shall, during his or her employment, service or thereafter, have no right, on any grounds, to receive compensation for Share Units that have been
forfeited in accordance with these terms and conditions. 
 In all cases, an Employee or his or her estate or beneficiary or heir shall be entitled to keep
such Shares that have already been delivered to an Employee or his or her estate or beneficiary or heir. 
 6. Application of Section 409A for US
Employees 
 Notwithstanding anything to the contrary herein, the following provisions apply to the extent benefits provided herein are “deferred
compensation” (Deferred Plan Benefits) within the meaning of Section 409A of the United States Internal Revenue Code and the regulations and other guidance thereunder and any state law of similar effect (collectively
Section 409A). The benefits pursuant to the 2014 Equity Plan are intended to qualify for 

  
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an exemption from application of Section 409A or comply with its requirements to the extent necessary to avoid adverse personal tax consequences under Section 409A for Employees subject
to United States federal income taxation, and any ambiguities herein shall be interpreted accordingly. Any Deferred Plan Benefits to be paid upon “termination of employment” shall not commence for an Employee subject to Section 409A
until the Employee has a “separation from service” for purposes of Section 409A. Any Deferred Plan Benefits to be paid upon a “merger” or similar provisions shall not commence until the Company has a “change in the
ownership or effective control or a change in the ownership of a substantial portion of the assets” within the meaning of Treas. Reg. Section 1.409A-3(i)(5). 

Each installment of any Deferred Plan Benefit is a separate “payment” for purposes of Treas. Reg. Section 1.409A-2(b)(2)(i), and any Deferred
Plan Benefits are intended to satisfy the exemptions from application of Section 409A provided under Treasury Regulations Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9). However, if such exemptions are not available and the Employee
is, upon separation from service, a “specified employee” for purposes of Section 409A, then, solely to the extent necessary to avoid adverse personal tax consequences under Section 409A, the timing of any affected Deferred Plan
Benefits payments shall be delayed until the earlier of (i) six (6) months and one day after the Employee’s separation from service, or (ii) the Employee’s death. In the event a benefit pursuant to the plan would qualify for
the “short term deferral exception” in Treasury Regulation Section 1.409A-1(b)(4) if vesting occurred on the Normal Vesting Date, then, if the Employee’s entitlement to keep the Share Units or to “exercise” the Share
Units occurs (Accelerated Vesting Date) prior to the Normal Vesting Date, (x) the Shares to be issued pursuant to such Share Units shall be issued no later than sixty (60) days after the Accelerated Vesting Date and (y) the
Subscription Price, if any, shall become immediately due and payable by the Employee whether or not the Share Unit is immediately “exercised” or the Shares issued on the Accelerated Vesting Date. 

  
 11EX-10.4

 Exhibit 10.4 

BIOTIE THERAPIES CORP. 
 STOCK OPTION PLAN 2014
(the 2014 Option Plan) 
 The Board of Directors of Biotie Therapies Corp. (the Board) has at its meeting on 2 January 2014 resolved,
by authorization of the Annual General Meeting of Shareholders of Biotie Therapies Corp. (the Company, or together with its subsidiaries the Group) on 4 April 2013, that stock options (Stock Options) be issued to the
personnel of the Company and of its subsidiaries (the Employees, or individually the Employee), on the following terms and conditions: 

I. STOCK OPTION TERMS AND CONDITIONS 
 1. Number of
Stock Options 
 The maximum total number of Stock Options which may be issued is 10,337,500, of which 4,320,000 are only available to Senior Management
as outlined further below. If the maximum number of Stock Options were to be granted, they would entitle their owners to subscribe for a maximum total of 10,337,500 new shares in the Company or existing shares held by the Company (Shares).

 2. Right to Stock Options 
 The Board shall
determine, in its absolute discretion, which Employees are to be granted Stock Options. The Board, in its absolute discretion, shall decide the timing of any grants, the quantum of any such grants and any special terms that should apply to such
grants consistent with this 2014 Option Plan. 
 Certain of the Stock Options are only for issue to the Chief Executive Officer, Chief Operating Officer,
Chief Medical Officer, Chief Financial Officer and by exception any other employee that the Board agrees at its sole discretion (together, the Senior Management) only. These Stock Options will be designated 2014M (as detailed in Section I.3
below) and are subject to additional criteria as outlined in Section I.6. (Senior Management Options). However, each member of Senior Management can only receive such units under either the 2014 Option Plan or the 2014 Equity Plan and not
both. 
 When deciding upon the quantum of any grant the Board may take into consideration the duration of employment or service of the Employee concerned
and such other factors as the Board may determine, including their expected contribution to the Group in future years. 
 The Stock Options shall be issued
at no cost to the Employees. The Company has a particularly weighty financial reason for the issue of Stock Options, since the Stock Options are intended to form part of the Group’s remuneration, incentive and commitment program for the
Employees and Senior Management. 
 3. Stock Options 

The Stock Options are divided into seven (7) tranches. The Stock Options shall be marked with a symbol to identify them by tranche. 468,125 shall be
marked 2014A, 1,404,375 shall be marked 2014B, 518,125 shall be marked 2014C, 1,554,375 shall be marked 2014D, 518,125 shall be marked 2014E, 1,554,375 shall be marked 2014F and 4,320,000 shall be marked 2014M. 

 The Employees, to whom Stock Options are offered, shall be notified in writing. The Stock Options shall be
delivered to the recipients in accordance with Section I.5. when the Employee has accepted the offer from the Board. 
 4. Discretionary Periods 

The 2014 Option Plan includes three (3) consecutive discretionary periods, calendar years 2014 (for Stock Options 2014A, 2014B and 2014M), 2015 (for Stock
Options 2014C and 2014D) and 2016 (for Stock Options 2014E and 2014F) (each separately, a Discretionary Period). If the Company’s financial year changes from being based on calendar years, before the end of a Discretionary Period, the
Board shall be entitled to change a Discretionary Period accordingly. 
 5. Grant of Stock Options 

During, or no more than one month before the commencement of each Discretionary Period, the Board shall, in its absolute discretion, determine what number of,
if any, Stock Options should be granted to the Employees and Senior Management. Grants may only be made to Employees and Senior Management who are employed by or in the service of the company belonging to the Group (Group Company) on the
grant date. However, the Board may pre-approve maximum awards for Employees that are expected to join the Group during the Discretionary Period in advance of them joining and allow the CEO to determine the level of the final award, subject to the
maximum pre-approved, when the Employee joins the Group. 
 If some Stock Options are not granted or they would otherwise be available because Stock Options
are returned to the Company (for example, if the Stock Options are forfeited when someone leaves the Group), they can be granted at a later time during the Discretionary Period. 

The Stock Options shall not constitute a part of employment or service contract of a Stock Option recipient, and they shall not be regarded as salary or
fringe benefit. Stock Option recipients shall have no right to receive compensation on any grounds, on the basis of Stock Options, during employment or service or thereafter. Stock Option recipients shall be liable for all taxes and tax-related
consequences arising from receiving or exercising Stock Options. 
 The Board shall have the right, in its absolute discretion, to reduce, including for the
avoidance of doubt to zero, the number of Stock Options to be granted, or to postpone the Stock Option grants to a later date that better suits the Company, if material changes that are beyond the Company’s control, such as legal, fiscal,
economic or business related factors, might lead to an extremely harmful or unreasonable outcome for the Company. 
 The Board shall have the right to
cancel the grant of any Stock Options or granted Stock Options that are subject to the transfer restriction, if the Group’s financial statements have to be restated, or if a Stock Option recipient has, in the reasonable opinion of the Board,
committed a serious criminal offence, broken any ethical code of which he has been notified by the Company or has otherwise acted in a way which the Board reasonably thinks might damage the reputation of the Company. 

  
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 6. Additional Criteria for certain Senior Management Options 

6.1 Purpose of Senior Management Options 
  

As detailed in Section I.2. certain of the Stock Options have been designated as 2014M and are only eligible for Senior Management. They are subject to
additional restrictions that increase the risk and reward for Senior Management and provide an additional incentive to increase shareholder value, as represented by the Company’s share price. 

Up to a maximum of 40% of the total awards expected to be made to each member of Senior Management in Discretionary Periods 2014, 2015 and 2016 will be
eligible to be included as Senior Management Options. This expectation will be based on three (3) times the total award made to each member of Senior Management in Discretionary Period 2014. 

6.2 Amount and Timing of Awards 
 There will only be one
award of Senior Management Options made to each member of Senior Management. 
 The Board at its sole discretion will determine the total amount of awards
for each member of Senior Management to be made in Discretionary Period 2014. 40% of these awards multiplied by three (3) will be included in tranche 2014M and termed Senior Management Option Units; the remaining 60% will be under the
same rules as other Employees and will be included in tranches 2014A and 2014B; in future periods (tranches 2014C, 2014D, 2014E and 2014F), only 60% of the total potential options will be awarded to Senior Management in lieu of the awards made in
tranches 2014M. 
 The total amount of award for each member of Senior Management made in each of Discretionary Periods 2015 and 2016 will be reduced by one
third of the Senior Management Option Units awarded in Discretionary Period 2014. 
 These Senior Management Option Units will be subject to a multiplier
depending on the growth in the Company’s share price (Multiplier), as detailed in Section 6.3. This Multiplier will then determine the amount of Stock Options that are awarded to each member of Senior Management. 

As an example and for the avoidance of doubt, if a member of Senior Management were to be made a total award of 300,000 Stock Options in the Discretionary
Period 2014, then 180,000 Stock Options (being 60% of 300,000) would be included in the total included in tranches 2014A and 2014B and 360,000 (being 40% of 300,000 multiplied by 3) will be included in tranche 2014M and be termed Senior Management
Option Units. Then the total awards made for Discretionary Periods 2015 and 2016 will be reduced by 120,000 Stock Options (being one third of the 360,000 Senior Management Option Units) in each and included in total in tranches 2014C and 2014D for
Discretionary Period 2015 and tranches 2014E and 2014F for Discretionary Period 2016. 
 6.3 Multiplier 

The Multiplier will be determined on the percentage growth in the share price from 1 January 2014 to 31 December 2016 (Share Price Growth).
The share price on each of 1 January 2014 and 31 December 2016 will be determined by the trade volume weighted average quotation of the Share on NASDAQ OMX Helsinki Ltd. for the preceding 30 days. 

The Multiplier will be calculated as follows: 
  

	 	•	 	For Share Price Growth of less than 35%, the Multiplier will be nil (0.0) times the Senior Management Option Units; and 

  
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	 	•	 	For Share Price Growth of between 35% and 100%, the Multiplier will be a straight line increase from nil (0.0) times the Senior Management Option Units at 35% to three (3.0) times the Senior Management Option Units
at 100%. This means that for each extra 1% of Share Price Growth between 35% and 100% the multiplier will increase by 0.046 times; the multiplier will be rounded to two decimal points; and 

 

	 	•	 	For Share Price Growth of greater than 100% the Multiplier will be a flat three (3.0) times the Senior Management Option Units. 

The result of applying the Multiplier to the Senior Management Option Units will then be equal to the Share Units that are eligible under tranche 2014M for
each member of Senior Management and subject to the Share Subscription Terms and Conditions detailed in Section II. 
 When determining the Multiplier, any
extraordinary events having occurred between 1 January 2014 and 31 December 2016, such as share splits, dividend payments, rights issues or similar events, shall be taken into account in a manner and at the discretion of the Board. 

7. Transfer and Forfeiture of Stock Options 
 7.1
Transfer of Stock Options 
 The Company shall hold the Stock Options on behalf of the Stock Option owner until the beginning of the share subscription
period. 
 The Stock Options are non-transferable to a third party by the Stock Option owner and may be exercised for share subscription only, unless
otherwise provided in Section II.7. The Board may, however, in its absolute discretion, permit the transfer or pledge of Stock Options, for example in selected countries. Should the Stock Option owner transfer his or her Stock Options in that case,
such person shall be obliged to inform the Company about the transfer or pledge in writing, without delay. 
 7.2 Termination of Employment or Service
before Share Subscription Period 
 Should a Stock Option owner’s employment or service in a Group Company terminate before the subscription period,
such person shall, without delay, forfeit to the Company or its designate, without compensation, all Stock Options granted to that individual, for which the relevant share subscription period specified in Section II.2. has not begun, on the last day
of such person’s employment or service. However, the Board may, in its absolute discretion, decide that the Stock Option owner is entitled to keep such Stock Options, or a part of them. 

Should a Stock Option owner become permanently disabled, retire statutorily or as determined by the Company, or die, after a Discretionary Period, a Stock
Option owner or his or her estate or beneficiary or heir shall be entitled to keep the granted Stock Options. 
 Should a Stock Option owner’s
employment or service in a Group Company end due to a corporate arrangement or transfer of business, after a Discretionary Period, a Stock Option owner shall be entitled to keep the granted Stock Options. 

  
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 In all cases, a Stock Option owner or his or her estate or beneficiary or heir shall be entitled to keep Stock
Options for which the relevant share subscription period specified in Section II.2. has begun. 
 A Stock Option owner shall, during his or her employment,
service or thereafter, have no right to receive compensation on any grounds for Stock Options that have been forfeited in accordance with these terms and conditions. 

7.3 Incorporation of Stock Options into the Book-entry Securities System 

The Board may decide to incorporate the Stock Options into the book-entry securities system. Should the Stock Options be incorporated into the book-entry
securities system, the Company shall have the right to request and get transferred all forfeited Stock Options from the Stock Option owner’s book-entry account to the book-entry account nominated by the Company, without the consent of the Stock
Option owner. In addition, the Company shall be entitled to register transfer restrictions and other restrictions concerning the Stock Options on the Stock Option owner’s book-entry account, without the consent of the Stock Option owner. 

II. SHARE SUBSCRIPTION TERMS AND CONDITIONS 
 1. Right
to subscribe for Shares 
 Each Stock Option entitles its owner to subscribe for one (1) new Share in the Company or an existing Share held by the
Company. The share subscription price shall be credited to the reserve for invested unrestricted equity. 
 2. Share Subscription and Payment 

The share subscription periods, which will apply separately to each employee, shall be: 

 

	 	•	 	for Stock Options 2014A, which will represent approximately 25% of the award made for the Discretionary Period 2014: 1 January 2016 to 28 February 2017; and 

 

	 	•	 	for Stock Options 2014B, which will represent approximately 75% of the award made for the Discretionary Period 2014: 1 January 2017 to 28 February 2018; and 

 

	 	•	 	for Stock Options 2014C, which will represent approximately 25% of the award made for the Discretionary Period 2015: 1 January 2017 to 28 February 2018; and 

 

	 	•	 	for Stock Options 2014D, which will represent approximately 75% of the award made for the Discretionary Period 2015: 1 January 2018 to 28 February 2019; and 

 

	 	•	 	for Stock Options 2014E, which will represent approximately 25% of the award made for the Discretionary Period 2016: 1 January 2018 to 28 February 2019; and 

 

	 	•	 	for Stock Options 2014F, which will represent approximately 75% of the award made for the Discretionary Period 2016: 1 January 2019 to 29 February 2020; and 

 

	 	•	 	for Stock Options 2014M: 1 January 2017 to 28 February 2018. 

 Should the last day of the share
subscription period not be a banking day, the share subscription may be made on a banking day following the last share subscription day. 
 Share
subscriptions shall take place at the head office of the Company or possibly at another location and in a manner to be determined later. Upon subscription, payment for the subscribed Shares shall be made to the bank account designated by the
Company. The Board shall decide on all measures concerning the share subscription and may, for example, determine that there will only be certain periods within each share subscription period during which it will issue the Shares. 

  
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 3. Share Subscription Price 

The share subscription price shall, for all Stock Options, be EUR 0.01. 

4. Registration of Shares 
 Shares subscribed for and
fully paid shall be registered on the book-entry account of the subscriber. 
 5. Shareholder Rights 

The dividend rights of the new Shares and other shareholder rights shall commence after the Shares have been entered into the Trade Register. 

Should existing Shares, held by the Company, be given to the subscriber of Shares, the subscriber shall be given the right to dividends and to other
shareholder rights after the Shares have been registered on his or her book-entry account. 
 6. Share Issues, Stock Options and Other Special Rights
entitling to Shares before Share Subscription 
 Should the Company, before the share subscription, decide on an issue of shares or an issue of new stock
options or other special rights entitling to shares, so that the shareholders have pre-emptive right to subscription, a Stock Option owner shall have the same right as, or an equal right to, that of a shareholder. Equality is reached in the manner
determined by the Board by adjusting the number of Shares available for subscription. The adjustment shall also be applied to Stock Options that have not yet been granted to the Employees. 

7. Rights in Certain Cases 
 7.1 Distribution of Assets

 Should the Company, differing from the Company’s normal practice, distribute dividends or similar assets from reserves of unrestricted equity,
after 2 January 2014 but before share subscription, the Board may decide on the adjustment of the number of Shares available for subscription so that the position of the Stock Option owner corresponds to that of a shareholder, as per the
dividend record date or the record date of the repayment of equity. The adjustment shall also be applied to Stock Options that have not yet been granted to the Employees. 

Should the Company reduce its share capital by distributing share capital to the shareholders, or reduce its share premium fund by distributing funds from the
share premium fund to the shareholders, after 2 January 2014 but before share subscription, the Board may decide on the adjustment of the number of Shares available for subscription so that the position of the Stock Option owner corresponds to
that of a shareholder, as per the record date of the repayment of share capital. The adjustment shall also be applied to Stock Options that have not yet been granted to the Employees. 

  
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 7.2 Liquidation or deregistration of the Company 

Should the Company be placed in liquidation before the share subscription, the Stock Option owner shall be given an opportunity to exercise his or her share
subscription right, within a period of time determined by the Board. Should the Company be deregistered, before the share subscription, the Stock Option owner shall have the same right as, or an equal right to, that of a shareholder. In this case,
the 2014 Option Plan shall expire. 
 7.3 Merger, Demerger or Transfer of Domicile 

Should the Company resolve to merge with another company as a merging company or merge with a company to be formed in a combination merger, or should the
Company resolve to be demerged entirely, the Stock Option owners may, prior to the registration of the execution of a merger or a demerger, be given the right to subscribe for Shares with their Stock Options, in a manner and within a period of time
determined by the Board. Alternatively, the Board may give a Stock Option owner the right to convert the Stock Options into stock options issued by the other company, in the manner determined in the draft terms of merger or demerger, or in the
manner otherwise determined by the Board, or the right to sell Stock Options prior to the registration of the execution of a merger or a demerger. After such period, no share subscription right or conversion right shall exist. The same proceeding
shall apply to cross-border mergers or demergers, or should the Company, after having registered itself as an European Company (Societas Europae), or otherwise, register a transfer of its domicile from Finland into another member state of the
European Economic Area. The Board shall decide on the impact of potential partial demerger on the Stock Options. In the above situations, the Stock Option owners shall have no right to require that the Company redeem the Stock Options from them at
their market value. 
 7.4 Acquisition or Redemption of Treasury Shares, Stock Options and other Special Rights entitling to Shares 

Acquisition or redemption of the Company’s treasury shares or acquisition of stock options or other special rights entitling to shares shall have no
impact on the rights of the Stock Option owner. Should the Company, however, resolve to acquire or redeem its treasury shares from all shareholders, the Stock Option owners shall be made an equivalent offer or an equivalent adjustment to the number
of Stock Options shall be made. 
 7.5 Redemption Right and Obligation 

Should a redemption right and obligation in relation to all of the Company’s shares, as referred to in Chapter 18 Section 1 of the Finnish Limited
Liability Companies Act, arise to any of the shareholders, during the share subscription period, on the basis that a shareholder possesses over 90 per cent of the shares and the votes of the shares of the Company, the Stock Option owners shall
be given the opportunity to exercise their right of share subscription by virtue of the Stock Options, within a period of time determined by the Board, or the Stock Option owners shall have an equal obligation to that of shareholders to transfer
their Stock Options to the redeemer, notwithstanding the fact that the Stock Options are non-transferable to a third party according to Section I.7. 

Should a redemption right or obligation arise before the subscription period in question, the Stock Option recipient may be granted the right to subscribe
Shares based on the Stock options as may be determined by the Board in its sole discretion upon arising of the redemption right and obligation and then given the same opportunities as outlined in the previous paragraph and the proceedings shall be
the same as above. In these cases, the 2014 Option Plan shall expire. 

  
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 III. OTHER MATTERS 

1. Applicable Law and Settlement of Disputes 
 These terms
and conditions shall be construed in accordance with and governed by the laws of Finland. All disputes arising in relation to the Stock Options shall be exclusively submitted to arbitration, in accordance with the Arbitration Rules of the Finland
Chamber of Commerce. The place of arbitration shall be Helsinki, Finland. The language of the arbitration proceedings shall be English or Finnish and the arbitral tribunal shall consist of one (1) arbitrator, who shall be appointed by the
Arbitration Institute of the Finland Chamber of Commerce. 
 Stock Options may be granted to individuals who are located outside Finland. The 2014 Option
Plan shall be operated in a way which complies with the law wherever the individuals are located. If the 2014 Option Plan needs to be completed in any way in order to comply with local law (whether in general or in relation to any particular grant,
including grants already made) then the Board may make such additions as it considers reasonably necessary and desirable, within the requirements of the laws of Finland. 

2. Amendment and Interpretation of the Terms and Conditions 

The Board shall be entitled to interpret the terms and conditions of the 2014 Option Plan. 

The Board shall manage the 2014 Option Plan and all matters relating thereto. The decision of the Board on any matters relating to the 2014 Option Plan shall
be final and binding on all parties. 
 The Board may delegate certain matters relating to the 2014 Option Plan to individuals within the Company as it sees
fit. 
 The Board may make any technical amendments required by the incorporation of the Stock Options into the book-entry securities system, to these terms
and conditions, as well as on other amendments and specifications to these terms and conditions which are not considered as essential. All matters related to the Stock Options shall be decided on by the Board. 

3. Administration of the 2014 Option Plan 
 Should the
Stock Option owner act against these terms and conditions, or against the instructions given by the Company, on the basis of these terms and conditions, or against applicable law, or against the regulations of the authorities, the Company shall be
entitled to withdraw, without paying any compensation, any Stock Options which have not been transferred, or with which Shares have not been subscribed for, from the Stock Option owner. 

The Company may maintain a register of the Stock Option owners on which the Stock Option owners’ personal data is recorded. A Stock Option owner accepts
that the data shall be administered and processed by the Company or any other agent or person designated by the Company. A Stock Option owner is entitled to request access to the data referring to him or her and held by the Company. The Company may
send all announcements regarding the Stock Options to the Stock Option owners by e-mail. 
 These terms and conditions have been prepared in Finnish and in
English. In the case of any discrepancy between the Finnish and English versions, the English shall prevail. 

  
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