Document:

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                                                                  EXHIBIT 10.13

                         [Letterhead NYCOMED AMERSHAM]

19th February, 2001
                                              Nycomed Amersham plc

Company Secretary                             Amersham Place
Amersham Pharmacia Biotech Limited            Little Chalfont
Amersham Place                                Buckinghamshire
Little Chalfont                               HP7 9NA England
Bucks HP7 9NA                                 T +44 (0) 1494 544000
                                              F +44 (0) 1494 542266

Attention: J.A. Cooper

Dear Sir,

GENERAL SERVICES AGREEMENT -- 4TH AUGUST, 1997 (THE "AGREEMENT") -- PROPOSED
AMENDMENT

As you are aware, we are in the process of making a public offering of
approximately 10% of the common stock which we currently hold in Amersham
Pharmacia Biotech Limited (or any successor company following a reorganisation
of the common stock) ("APBiotech").

With reference to Clause 8.7 of the Agreement, it has been agreed that in
future the circumstances in which Nycomed Amersham plc shall be entitled to
terminate the Agreement on three months' notice shall be when Nycomed Amersham
ceases to have the right to nominate the majority of the Board of Directors of
APBiotech, rather than on ceasing to have a direct or indirect interest in at
least 50% of the voting rights attaching to the stock of APBiotech.

Clause 8.7 shall therefore be amended as follows:

"8.7  International may terminate this Agreement on three months' notice ending
      on or after the date on which International ceases to have the right to
      nominate the majority of the Board of Directors of Biotech."

Please acknowledge agreement by countersigning this letter and returning it
to me.

Yours sincerely,

/s/ G.F.B. Kerr
------------------
G.F.B. Kerr
Finance Director                        Agreed:
                                        /s/ J.A. Cooper
                                        --------------------------------------
                                        J.A. Cooper
                                        For Amersham Pharmacia Biotech Limited<PAGE>   1
                                                                   EXHIBIT 10.14

                                 APBIOTECH INC

                                  RULES OF THE
                               APBIOTECH OPTIONS
                               FOR ALL PLAN 2000

                           FOR ADOPTION BY APBIOTECH
                                   INC BOARD

                                 FEBRUARY 2001
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                                    CONTENTS

<TABLE>
<CAPTION>
                                                                            PAGE
<S>   <C>                                                                   <C>
                                     PART A

1.    Meanings of Words used............................................       1

2.    Grant of Options..................................................       3

3.    Option Price......................................................       5

4.    Variations in Share Capital.......................................       5

5.    Exercise and Lapse - General Rules................................       5

6.    Cessation of Employment...........................................       6

7.    Exercise of Options...............................................       8

8.    General...........................................................      10

9.    Amendments and Termination........................................      10

10.   Governing Law.....................................................      11

                                     PART B

1.    Meanings of Words Used............................................      12

2.    Grant of Options..................................................      13

3.    Option Price......................................................      15

4.    UK Inland Revenue Individual(pound)30,000 limit...................      15

5.    Variations in Share Capital.......................................      16

6.    Exercise and Lapse - General Rules................................      16

7.    Cessation of Employment...........................................      17

8.    Exercise of Options...............................................      19

9.    General...........................................................      20

10.   Amendments and Termination........................................      21

11.   Governing Law.....................................................      22

SCHEDULE 1 - INCENTIVE STOCK OPTION SCHEDULE                                  23

SCHEDULE 2 - CASH OPTION PLAN                                                 25

</TABLE>

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                                  RULES OF THE

                       APBIOTECH OPTIONS FOR ALL PLAN 2000

                                     PART A

1.       MEANINGS OF WORDS USED

1.1      In these Rules:

         "ASSOCIATED COMPANY" has the meaning given to is by Section 416 of the
         U.K. Taxes Act;

         "BUSINESS DAY" means a day on which NASDAQ is open for the transaction
         of business;

         "COMPANY" means APBiotech Inc;

         "CONTROL" has the meaning given to it by section 840 of the U.K. Taxes
         Act;

         "DATE OF GRANT" means the date on which the Directors resolve to grant
         an Option;

         "DIRECTORS" means the Board of Directors of the Company or a duly
         authorised committee of it;

         "ELIGIBLE EMPLOYEE" means any person who is a common law employee of a
         Participating Company who devotes substantially the whole of his
         working time to his duties;

         "EMPLOYEES' SHARE PLAN" means a plan for encouraging or facilitating
         the holding of shares in the Company by or for the benefit of the bona
         fide employees or former employees of the Company, the Company's
         subsidiary or holding company or a subsidiary of the Company's holding
         company;

         "MARKET VALUE" means in relation to a Share:

         (i)    If Shares are listed on a national securities exchange or traded
                in the over-the-counter market and sales prices are regularly
                reported for Shares, either (a) the average of the low and high
                prices of the Shares on the composite tape or other comparable
                reporting system for the applicable date, or if the applicable
                date is not a trading day, for the trading day immediately
                preceding the applicable date or (b) the closing or last price
                of Shares on the composite tape or other comparable reporting
                system for the applicable date, or if the applicable date is not
                a trading day, for the trading day  immediately  preceding the
                applicable date, as the Option Committee shall determine.

         (ii)   If Shares are not traded on a national securities exchange but
                are traded on the over-the-counter market, if sales prices are
                not regularly reported for the Shares for the trading days or
                day referred to in clause (1), and if bid and asked prices for
                the Shares are regularly reported, the mean between the bid and
                the asked price for the Shares at the close of trading in the
                over-the-counter market for the trading day on which Shares were
                traded immediately preceding the applicable date, as the Option
                Committee shall determine; and

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         (iii)  If the Shares are neither listed on a national securities
                exchange nor traded in the over-the-counter market, such value
                as the Option Committee, in good faith, shall determine.

         "MEMBERS OF THE GROUP" means the Company and all Subsidiaries and
         Associated Companies of it from time to time;

         "OPTION"  means a right to acquire Shares granted pursuant to the Plan
         and for the time being subsisting;

         "OPTION COMMITTEE" means a duly appointed committee of the Directors
         comprising Directors who:

         (i)    do not hold any executive office with any Member of the Group;
                and

         (ii)   will not themselves participate in the Plan;

         "OPTION EXERCISE DATE" means the date when an Option is effectively
         exercised upon compliance with the provisions of Rule 7.1;

         "OPTION HOLDER" means a person holding an Option, including, where the
         context so permits, his personal representatives;

         "OPTION PERIOD" means, in respect of an Option, a period commencing on
         the Date of Grant and expiring at the close of business on the day
         preceding the 10th anniversary of the Date of Grant;

         "OPTION PRICE" means the price per Share payable on the exercise of an
         Option as determined by the Option Committee under Rule 3;

         "ORIGINAL SHAREHOLDER" means Nycomed Amersham plc (or any subsidiary of
         Nycomed Amersham plc) or Pharmacia Corp (or any subsidiary of Pharmacia
         Corp);

         "PARTICIPATING COMPANIES" means the Company and any Subsidiary of the
         Company, direct or indirect, designated by the Option Committee as a
         Participating Company;

         "PLAN" means this plan known as "The APBiotech Inc. Options for All
         Plan 2000" in its present form or as from time to time altered in
         accordance with the Rules;

         "PLAN PERIOD" means the period commencing on the date of the approval
         of the Plan by the Directors and ending on the 10th anniversary of that
         date;

         "RULES" means these rules as amended from time to time;

         "SHARES" means shares in the Company's Common Stock, $0.01 par value;

         "SUBSIDIARY" means a company which is:

         (i)    a subsidiary of the Company within the meaning given thereto by
                Section 736 of the U.K. Companies Act 1985, and

         (ii)   under the Control of the Company;

         "TAXES ACT" means the Income and Corporation Taxes Act 1988; and

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         "YEAR" means a year beginning on any January 1 and ending the following
         December 31.

1.2      Where the context so admits or requires, the singular includes the
         plural and the masculine includes the feminine and vice versa;
         references to any statutory provision shall include any modification or
         re-enactment.

1.3      Headings shall be ignored in construing the Rules.

2.       GRANT OF OPTIONS

2.1      GRANT OF OPTIONS

         Subject to Rule 2.10 below, the Option Committee may during the Plan
         Period in its absolute discretion grant to any Eligible Employee an
         Option to acquire such number of Shares as the Option Committee may
         determine (or such lesser number as may be the case following an
         adjustment under Rule 2.8) at the Option Price.

2.2      TIME WHEN OPTIONS MAY BE GRANTED

         Options shall only be granted at such times as may be permitted by
         applicable securities laws.

2.3      CONDITIONS ON EXERCISE

         The Option Committee may grant an Option on the basis that it may not
         be exercised, in whole or in part, until certain conditions have been
         satisfied.

         The Option Committee may in its discretion waive, vary or amend any
         such condition. Such discretion shall only be exercised if events
         happen which cause the Option Committee to consider that a waived,
         varied or amended condition would be a fairer measure of performance
         and would be no more difficult to satisfy.

2.4      OPTION CERTIFICATES

         Each Option Holder shall be issued an option certificate, on or as soon
         as practicable after the Date of Grant, in such form as the Option
         Committee shall prescribe.

2.5      NO PAYMENT

         No payment to the Company shall be required on the grant of an Option.

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2.6      DISCLAIMER OF OPTION

         Any Option Holder may, by notice in writing to the Secretary of the
         Company, within 30 days after the Date of Grant, disclaim in whole his
         Option and in such case the Option shall be deemed never to have been
         granted under the Plan. No consideration shall be payable for any
         disclaimer.

2.7      DISPOSAL RESTRICTIONS

         Except for the transmission of an Option on the death of an Option
         Holder to his personal representatives, neither an Option nor any
         rights in respect of it may be transferred, assigned or otherwise
         disposed of by an Option Holder to any other person, and if an Option
         Holder purports to transfer, assigns or disposes of any such Option or
         rights, whether voluntarily or involuntarily, then the relevant Option
         shall immediately lapse.

2.8      BLUE PENCIL PROVISION

         If any Option is purported to be granted on terms which are not in
         accordance with the provisions of these Rules, including the
         limitations on participation and the calculation of the Option Price,
         the Option Committee shall vary the terms of such Option to bring the
         Option within the Rules and any such variation shall take effect from
         the Date of Grant.

2.9      LIMITS ON SHARES AVAILABLE

         2.9.1    Subject to Rules 2.9.2 and 2.9.3 below, no Options shall be
                  granted under the Plan which would, at the time they are
                  granted, cause the number of Shares which may be issued in
                  pursuance of Options granted under the Plan, or in pursuance
                  of options or other awards made under any other Employees'
                  Share Plan of the Company, to exceed such number as represents
                  3% of the ordinary share capital of the Company from time to
                  time.

         2.9.2    The limit at Rule 2.9.1 above shall apply from the date of
                  adoption of the Plan by the Company until such date as
                  determined by the Directors, which shall not be before 1 June
                  2002 at the earliest.

         2.9.3    Only those Shares which are capable of being issued before 1
                  June 2002 (or such later date as determined by the Directors
                  pursuant to Rule 2.9.2 above) on the exercise of any options
                  or other awards will be relevant for the purposes of
                  calculating the limit in Rule 2.9.1 above, and Shares shall
                  not be regarded as being capable of being issued by reason of
                  any provisions in the relevant Employees' Share Plans under
                  which such options or awards are granted allowing a person to
                  exercise an option or award in circumstances of leaving
                  employment or a change of control of the Company.

2.10     LIMIT ON INDIVIDUAL PARTICIPATION

         The maximum number of Shares over which Options can be granted to an
         Eligible Employee in any year is 1,000,000 Shares.

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3.       OPTION PRICE

3.1      DETERMINATION OF OPTION PRICE

         The Option Committee shall determine the Option Price which shall be
         stated at the Date of Grant and shall not be less than Market Value of
         a Share on the Date of Grant.

4.       VARIATIONS IN SHARE CAPITAL

4.1      ADJUSTMENT OF OPTIONS

         In the event (a "Relevant Event") of any variation in the equity share
         capital of the Company in consequence of a capitalisation or rights
         issue, sub-division, consolidation or reduction of share capital or
         other variation in the share capital:

         4.1.1    the number or nominal amount of Shares comprised in each
                  Option, and/or

         4.1.2    the Option Price, and/or

         4.1.3    the aggregate Option Price  in relation to any Option,

         may be adjusted in such manner as the Directors consider appropriate
         (including retrospective adjustment where such Relevant Event or the
         variation in the equity share capital of the Company as a consequence
         of the Relevant Event occurs after the Option Exercise Date but the
         relevant record date precedes such Option Exercise Date). If and to the
         extent a Relevant Event is a change in the number or kind of Shares
         effected solely by application of a mathematical formula (e.g., a
         2-for-1 stock split), the adjustment described in this Rule 4.1 shall
         be made and shall occur automatically by application of such formula,
         without further action by the Directors.

4.2      OTHER RELEVANT EVENTS

         Options may be adjusted following variations in the share capital of
         the Company other than those specified in Rule 4.1. Any such
         adjustments shall be made in accordance with Rule 4.1.

4.3      NOTICE

         The Directors may take such steps as they consider necessary to notify
         Option Holders of any adjustment made under this Rule 4.

5.       EXERCISE AND LAPSE - GENERAL RULES

5.1      EXERCISE - GENERAL RULE

         Unless otherwise specified in these Rules an Option shall only be
         exercisable:

         5.1.1    on or after the third anniversary of the Date of Grant
                  (subject to Rule 6 applying);

         5.1.2    on the satisfaction or waiver of any condition imposed under
                  Rule 2.3;

         5.1.3    except as provided in Rule 6, while the Option Holder is an
                  employee of a Member of the Group; and

         5.1.4    in such periods (if any) as are specified by the Board at the
                  time the option is granted.

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5.2      LAPSE

         Options shall lapse on the expiry of the Option Period.

6.       CESSATION OF EMPLOYMENT

6.1      GENERAL RULE

         If an Option Holder ceases to be an employee of any Member of the Group
         (except for any reason specified in Rule 6.2 below) then:

         6.1.1 all Options granted less than 3 years before cessation shall
         lapse and determine upon such cessation; and

         6.1.2 all other Options shall be exercisable within 6 months of such
         cessation (but not after the expiry of the Option Period) and if not so
         exercised shall lapse and determine.

6.2      CESSATION OF EMPLOYMENT - SPECIAL CASES

         If an Option Holder ceases to be an employee of any Member of the Group

         6.2.1    by reason of retirement; or

         6.2.2    by reason of injury, disability or dismissal for redundancy,
                  or by reason only that his office or employment is in a
                  company which ceases to be a Member of the Group, or relates
                  to a business or part of a business which is transferred to a
                  person who is not a Member of the Group; or

         6.2.3    by reason of death

         then the Option shall become exercisable and may be exercised by the
         Option Holder (or by his personal representatives if appropriate) to
         the extent permitted by Rule 6.3 and within the exercise period as set
         out in Rule 6.4.

         For the purposes of this Rule 6.2, whether an Option Holder has ceased
         to be an employee of any member of the group by reason of retirement,
         injury, disability or dismissal for redundancy shall be determined by
         the directors, whose decision on such matter shall be final and
         binding.

6.3      The extent to which an Option shall become exercisable and may be
         exercised in accordance with this Rule is that one sixth of the Option
         can be exercised for each full period of six months from the Date of
         Grant until the relevant cessation of employment during which the
         Option Holder was an employee of a Member of the Group.

6.4      The exercise period referred to at Rule 6.2 above is

         6.4.1    in the case of death, the period of 12 months from the date of
                  death; and

         6.4.2    in all other circumstances considered in Rule 6.2 above, the
                  period which shall expire 6 months after his so ceasing or 42
                  months after the Grant Date, whichever shall be the later

         provided that no Option can be exercised after the expiry of the Option
         Period.

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6.5      LEAVE OF ABSENCE

         No Options that are not exercisable at the beginning of an authorised
         leave of absence shall become exercisable during such leave of absence.

6.6      TAKE-OVERS ETC.

         6.6.1    Subject to Rule 6.6.4 below, if, in consequence of any offer
                  made to the holders of Shares, the Directors become aware that
                  the right to cast more than 50 per cent of the votes which may
                  ordinarily be cast on a poll at a general meeting of the
                  Company has or will become vested in the offeror and/or any
                  company controlled by the offeror and/or any person associated
                  with or acting in concert with the offeror, the Directors
                  shall, within 30 days of becoming so aware, notify every
                  Option Holder accordingly.

         6.6.2    Each Option Holder shall be entitled at any time during the
                  Change of Control Period to exercise all his Options (whether
                  or not otherwise exercisable) in whole or in part. The Options
                  shall not lapse on the expiry of the Change of Control Period
                  but all Options not exercisable immediately prior to the
                  beginning of the Change of Control Period shall cease to be
                  exercisable on the expiry of the Change of Control Period.

         6.6.3    For the purposes of this Rule 6, "Change of Control Period"
                  means the period commencing on the date of the giving of the
                  Directors' notification under this Rule 6.6 and ending three
                  months after that.

         6.6.4    Unless the Directors decide otherwise, the provisions of this
                  Rule 6.6 shall not apply if an Original Shareholder shall
                  become entitled to cast more than 50% of the votes which may
                  ordinarily be cast on a poll at a general meeting of the
                  Company.

6.7      WINDING UP

         In the event of the proposed dissolution or liquidation of the Company,
         all outstanding Options will terminate immediately prior to the
         consummation of such proposed action, unless otherwise provided by the
         Option Committee; provided, however, that if the rights of an Option
         Holder (or his personal representatives if appropriate) have not
         otherwise terminated and expired, the Option Holder (or his personal
         representatives if appropriate) will have the right immediately prior
         to such dissolution or liquidation to exercise any option to the extent
         that the Option is exercisable as of the date immediately prior to such
         dissolution or liquidation, and the Option Committee may, in the
         exercise of its sole discretion in such instances, accelerate the date
         on which any Option becomes exercisable or fully vests and/or declare
         that any Option shall terminate as of a specified date.

6.8      LOSS OF OWNERSHIP

         Where the Option Holder is deprived of the legal or beneficial
         ownership of the Option by operation of law, or does anything or omits
         to do anything which causes him to be so deprived or becomes bankrupt,
         all his Options shall lapse.

6.9      OVERSEAS TRANSFER

         If an Option Holder, whilst continuing to hold an office or employment
         with a Member of the Group is transferred to work in another country
         and as a result of that transfer the Option Holder will either:

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         6.9.1    become subject to tax on his remuneration in the country to
                  which he is transferred and the Option Committee are satisfied
                  that as a result he will suffer a tax disadvantage upon
                  exercising an Option; or

         6.9.2    become subject to restrictions on his ability to exercise his
                  Option or to hold or deal in the Shares or the proceeds of the
                  sale of the Shares he may acquire upon the exercise of that
                  Option by reason of or in consequence of the security laws or
                  exchange laws of the country to which he is transferred;

         the Option Committee (or its delegate) may allow the Option Holder to
         exercise the Option in a period specified by the Option Committee or
         its delegate. The Options will become exercisable again in the ordinary
         course if not so exercised.

6.10     PRIORITY

         In the event of any conflict between any of the provisions of Rules 5
         and 6, the provisions which results in the earliest lapsing of the
         Option in question shall prevail.

7.       EXERCISE OPTIONS

7.1      LIMIT ON EXERCISE

         An Option may only be exercised during the periods specified in Rules 5
         and 6.

7.2      MANNER OF EXERCISE

         To exercise an Option in whole or in part, an Option Holder must
         deliver to the Secretary of the Company or other duly appointed agent:

         7.2.1    the option certificate covering the Shares over which the
                  Option is being exercised;

         7.2.2    notice in writing, in the prescribed form, duly completed and
                  signed by the Option Holder or by his duly appointed agent;
                  and

         7.2.3    payment in full of the Option Price for the total number of
                  Shares in respect of which the Option is being exercised.

         The Option Holder shall pay the Option Price for an Option as specified
         by the Option Committee (x) in cash, (y) with the approval of the
         Option Committee, by delivering Shares owned by the Option Holder
         (including shares acquired in connection with the exercise of an
         Option, subject to such restrictions as the Option Committee deems
         appropriate) and having a Market Value on the Option Exercise Date
         equal to the Option Price or (z) by such other method as the Option
         Committee may approve, including attestation (on a form prescribed by
         the Option Committee) to ownership of Shares having a Market Value on
         the Option

         Exercise Date equal to the Option Price, or payment through a broker in
         accordance with procedures permitted by Regulation T of the United
         States Federal Reserve Board. Shares used to exercise an Option shall
         have been held by the Option Holder for the requisite period of time to
         avoid adverse accounting consequences to the Company with respect to
         the Option. The Option Holder shall pay the Option Price and the amount
         of any withholding tax due at the time of exercise. Shares shall not be
         issued upon exercise of an Option until the Option Price is fully paid
         and any required withholding is made.

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<PAGE>   11

         If the Option Committee so permits, an Option Holder subject to the
         United States tax may elect to satisfy the Company's income tax
         withholding obligation with respect to an Option by having Shares
         withheld having a Market Value up to an amount that does not exceed the
         Option Holder's minimum applicable withholding tax rate for federal
         (including FICA), state and local tax liabilities. The election must be
         in a form and manner prescribed by the Option Committee and shall be
         subject to the prior approval of the Option Committee.

7.3      TRANSFER

         Subject to Rule 7.5 and Rule 7.6, the Directors shall allot the shares
         to be issued or shall procure the transfer of Shares to be transferred
         following the exercise of an Option within 30 days of the Option
         Exercise Date.

7.4      RIGHTS

         In respect of Shares issued or transferred on the exercise of an
         Option, Option Holders are entitled to all rights attaching to such
         Shares by reference to a record date after the Option Exercise Date.
         They shall not be entitled to rights before such date.

7.5      CONSENTS

         All allotments, issues and transfers of Shares will be subject to any
         necessary consents or other applicable requirements or restrictions
         under any relevant enactments or regulations for the time being in
         force in the United Kingdom and the United States or elsewhere, and it
         shall be the responsibility of the Option Holder to comply with any
         requirements to be fulfilled in order to obtain or obviate the
         necessity for any such consent.

7.6      TAX WITHHOLDING

         In a case where a Member of the Group is obliged to (or would suffer a
         disadvantage if it were not to) account for any tax (in any
         jurisdiction) for which the person exercising an Option is liable by
         virtue of the exercise of the Option and/or for any social security
         contributions recoverable from the person in question (together, the
         "Tax Liability), no Shares shall be issued or transferred following the
         exercise of an Option unless that person has either:

         (i)    made a payment to the Member of the Group of an amount equal to
                the Tax Liability; or

         (ii)   entered into arrangements acceptable to that or another Member
                of the Group to secure that such a payment is made (whether by
                authorising the sale of some or all of the Shares on his behalf
                and the payment to the Member of the Group of the relevant
                amount out of the proceeds of sale or otherwise).

7.7      ARTICLES OF ASSOCIATION

         Any Shares acquired upon the exercise of Option shall be subject to the
         Articles of Incorporation and the By-Laws of the Company from time to
         time in force.

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<PAGE>   12
8.       GENERAL

8.1      NOTICES

         Any notice or other document required to be given under or in
         connection with the Plan may be delivered to an Option Holder or sent
         by post to him at his home address according to the records of his
         employing company or such other address as may appear to the Company to
         be appropriate. Notices sent by post shall be deemed to have been given
         on the day following the date of posting. Any notice or other document
         required to be given to the Company under or in connection with the
         Plan may be delivered or sent by post to it at its registered office
         (or such other place or places as the Directors may from time to time
         determine and notify the Option Holders).

8.2      AVAILABILITY OF SHARES

         The Company shall procure that sufficient Shares are available for
         transfer or issue to satisfy all Options under which Shares may be
         acquired.

8.3      DIRECTORS' DECISION FINAL AND BINDING

         The decision of the Directors in any dispute relating to an Option or
         matter relating to the Plan shall be final and conclusive.

8.4      COSTS

         The costs of introducing and administering the Plan shall be borne by
         the Company.

8.5      REGULATIONS

         The Directors shall have power from time to time to make or vary
         regulations for the administration and operation of the Plan provided
         that the same are not inconsistent with these Rules.

8.6      LIMITATION OF LIABILITY

         The rights and obligations of an Option Holder under the terms and
         conditions of his office or employment shall not be affected by his
         participation in the Plan or any right he may have to participate in
         the Plan. An individual who participates in the Plan waives all and any
         rights to compensation or damages in consequence of the termination of
         his office or employment with any company for any reason whatsoever
         insofar as those rights arise, or may arise, from his ceasing to have
         rights under or be entitled to exercise any Option under the Plan as a
         result of such termination or from the loss or diminution in value of
         such rights or entitlements. If necessary the Option Holder's terms of
         employment shall be varied accordingly.

9.       AMENDMENTS AND TERMINATION

9.1      DIRECTORS' POWERS OF AMENDMENT

         The Directors may at any time alter or add to all or any of the
         provisions of the Plan or any previously granted Option in any respect;
         provided that no such amendment shall materially impair the rights of
         any Option Holder under any previously granted Option unless the
         amendment is required by applicable law, or

         9.1.1    the Directors shall have invited every relevant Option Holder
                  to give an indication as to whether or not he approves of the
                  amendment; and

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         9.1.2    the alteration is approved by a majority of those Option
                  Holders who have given such an indication.

9.2      OVERSEAS EMPLOYEES

         Notwithstanding any other provision of the Plan the Directors may, in
         respect of Options granted to Eligible Employees who are or who may
         become subject to taxation outside the United States on their
         remuneration, amend or add to the provisions of the Plan and the terms
         of Options as they consider necessary or desirable to take account of
         or to mitigate or to comply with relevant overseas taxation,
         securities, exchange control and/or other overseas laws, provided that
         the terms of Options granted to such Eligible Employees are not overall
         more favourable than the terms of Options granted to other Eligible
         Employees.

9.3      NOTICE

         As soon as reasonably practicable after making any alteration or
         addition, the Directors shall give written notice to any Option Holder
         affected by the alteration or addition.

9.4      TERMINATION OF THE PLAN

         The Directors may terminate the Plan at any time, and it shall
         terminate on the 10th anniversary of its adoption by the Directors, but
         Options granted prior to such termination shall continue to be valid
         and exercisable in accordance with these Rules.

10.      GOVERNING LAW

         The Plan and all Options shall be governed by and construed in
         accordance with [applicable state] law.

                                                                              11
<PAGE>   14

                                  RULES OF THE

                       APBIOTECH OPTIONS FOR ALL PLAN 2000

                                     PART B

1.       MEANINGS OF WORDS USED

1.1      In these Rules:

         "ASSOCIATED COMPANY" has the meaning given to it by section 416 of the
         U.K. Taxes Act;

         "BUSINESS DAY" means a day on which NASDAQ is open for the transaction
         of business;

         "COMPANY" means APBiotech Inc;

         "CONTROL" has the meaning given to it by Section 840 of the U.K. Taxes
         Act;

         "DATE OF GRANT" means the date on which the Directors resolve to grant
         an Option;

         "DIRECTORS" means the Board of Directors of the Company or a duly
         authorised committee of it;

         "ELIGIBLE EMPLOYEE" means either a full-time director of a
         Participating Company (who is obliged to devote the performance of the
         duties of his office or employment with that and any other
         Participating Company not less than 25 hours per week) or an employee
         of a Participating Company (other than one who is a director of a
         Participating Company);

         "EMPLOYEES' SHARE PLAN" means a plan for encouraging or facilitating
         the holding of shares in the Company by or for the benefit of the bona
         fide employees or former employees of the Company, the Company's
         subsidiary or holding company or a subsidiary of the Company's holding
         company;

         "MARKET VALUE" means in relation to a Share the market value (within
         the meaning of Part VIII of the UK Taxation of Chargeable Gains Act
         1992) of shares of that class, as agreed in advance for the purposes of
         this scheme with the Shares Valuation Division of the Inland Revenue;

         "MEMBER OF THE GROUP" means the Company and all Subsidiaries and
         Associated Companies of it from time to time;

         "OPTION" means a right to acquire Shares granted pursuant to the Plan
         and for the time being subsisting;

         "OPTION COMMITTEE" means a duly appointed committee of the Directors
         comprising Directors who:

         (i)    do not hold any executive office with any Member of the Group;
                and

         (ii)   will not themselves participate in the Plan;

         "OPTION EXERCISE DATE" means the date when an Option is effectively
         exercised upon compliance with the provisions of Rule 8.1;

                                                                              12
<PAGE>   15

         "OPTION HOLDER" means a person holding an Option, including, where the
         context so permits, his personal representatives;

         "OPTION PERIOD" means, in respect of an Option, a period commencing on
         the Date of Grant and expiring at the close of business on the day
         preceding the 10th anniversary of the Date of Grant;

         "OPTION PRICE" means the price per Share payable on the exercise of an
         Option as determined by the Option Committee under Rule 3;

         "ORIGINAL SHAREHOLDER" means Nycomed Amersham plc (or any subsidiary of
         Nycomed Amersham plc) or Pharmacia Corp (or any subsidiary of Pharmacia
         Corp);

         "PART B" means the part of this Plan designed for approval by the
         Inland Revenue under Schedule 9;

         "PARTICIPATING COMPANIES" means the Company and any Subsidiary of the
         Company, direct or indirect, designated by the Option Committee as a
         Participating Company;

         "PLAN" means this plan known as "The APBiotech Inc. Options For All
         Plan 2000" in its present form or as from time to time altered in
         accordance with the Rules;

         "PLAN PERIOD" means the period commencing on the date of the approval
         of the Plan by the Directors and ending on the 10th anniversary of that
         date;

         "RULES" means these rules as amended from time to time;

         "SCHEDULE 9" means Schedule 9 to the Taxes Act;

         "SHARES" means shares in the Company's Common Stock, $0.01 par value;

         "SUBSIDIARY" means a company which is:

         (i)    a subsidiary of the Company within the meaning given thereto by
                Section 736 of the U.K. Companies Act 1985, and

         (ii)   under the Control of the Company;

         "TAXES ACT" means the Income and Corporation Taxes Act 1988; and

         "YEAR" means a year beginning on any January 1 and ending the following
         December 31.

1.2      Where the context so admits or requires, the singular includes the
         plural and the masculine includes the feminine and vice versa;
         references to any statutory provision shall include any modification or
         re-enactment.

1.3      Headings and words in italics shall be ignored in construing the Rules.

2.       GRANT OF OPTIONS

2.1      GRANT OF OPTIONS

         2.1.1    Subject to Rule 2.10, the Option Committee may during the Plan
                  Period in its absolute discretion grant to any Eligible
                  Employee an Option under this Part B to

                                                                              13
<PAGE>   16

                  acquire such number of Shares as the Option Committee may
                  determine (or such lesser number as may be the case following
                  an adjustment under Rule 2.8) at the Option Price where such
                  Shares satisfy the requirements of paragraphs 10 to 14 of
                  Schedule 9 (fully paid up, unrestricted, ordinary share
                  capital).

         2.1.2    A person is not eligible to be granted an Option at any time
                  under this Part B when he is not eligible to participate in
                  this Scheme by virtue of paragraph 8 of Schedule 9 (material
                  interest in a close company).

2.2      TIME WHEN OPTIONS MAY BE GRANTED

         Options shall only be granted at such times as may be permitted by
         applicable securities laws.

2.3      CONDITIONS ON EXERCISE

         The Option Committee may grant an Option on the basis that it may not
         be exercised, in whole or in part, until certain objective conditions
         relating to the performance of the Company have been satisfied.

         The Option Committee may in its discretion waive, vary or amend any
         such condition. Such discretion shall only be exercised if events
         happen which cause the Option Committee to consider that a waived,
         varied or amended condition would be a fairer measure of performance
         and would be no more difficult to satisfy.

2.4      OPTION CERTIFICATES

         Each Option Holder shall be issued an option certificate, on or as soon
         as practicable after the Date of Grant, in such form as the Option
         Committee shall prescribe.

2.5      NO PAYMENT

         No payment to the Company shall be required on the grant of an Option.
         Options will be granted by deed.

2.6      DISCLAIMER OF OPTION

         Any Option Holder may, by notice in writing to the Secretary of the
         Company, within 30 days after the Date of Grant, disclaim in whole his
         Option and in such case the Option shall be deemed never to have been
         granted under the Plan. No consideration shall be payable for any
         disclaimer.

2.7      DISPOSAL RESTRICTIONS

         Except for the transmission of an Option on the death of an Option
         Holder to his personal representatives, neither an Option nor any
         rights in respect of it may be transferred, assigned or otherwise
         disposed of by an Option Holder to any other person, and if an Option
         Holder purports to transfer, assigns or disposes of any such Option or
         rights, whether voluntarily or involuntarily, then the relevant Option
         shall immediately lapse.

2.8      BLUE PENCIL PROVISION

         If any Option is purported to be granted on terms which are not in
         accordance with the provisions of these Rules, including the
         limitations on participation and the calculation of the

                                                                              14
<PAGE>   17
         Option Price, the Option Committee shall vary the terms of such Option
         to bring the Option within the Rules and any such variation shall take
         effect from the Date of Grant.

2.9      LIMITS ON SHARES AVAILABLE

         2.9.1    Subject to Rules 2.9.2 and 2.9.3 below, no Options shall be
                  granted under the Plan which would, at any time they are
                  granted, cause the number of Shares which may be issued in
                  pursuance of Options granted under the Plan, or in pursuance
                  of options or other awards made under any other Employees'
                  Share Plan of the Company, to exceed such number as represents
                  3% of the ordinary share capital of the Company from time to
                  time.

         2.9.2    The limit at Rule 2.9.1 above shall apply from the date of
                  adoption of the Plan by the Company until such date as
                  determined by the Directors, which shall not be before 1 June
                  2002 at the earliest.

         2.9.3    Only those Shares which are capable of being issued before 1
                  June 2002 (or such later date as determined by the Directors
                  pursuant to Rule 2.9.2. above) on the exercise of any options
                  or other awards will be relevant for the purposes of
                  calculating the limit in Rule 2.91. above, and Shares shall
                  not be regarded as being capable of being issued by reason of
                  any provisions in the relevant Employees' Share Plan under
                  which such options or awards are granted allowing a person to
                  exercise an option or award in circumstances of leaving
                  employment or a change of control of the Company.

2.10     LIMIT ON INDIVIDUAL PARTICIPATION

         The maximum number of Shares over which Options can be granted to an
         Eligible Employee in any year is 1,000,000 Shares.

3.       OPTION PRICE

3.1      DETERMINATION OF OPTION PRICE

         The Option Committee shall determine the Option Price which shall be
         stated at the Date of Grant and shall not be less than the Market Value
         of a Share on the Date of Grant.

4.       UK INLAND REVENUE INDIVIDUAL (POUND)30,000 LIMIT

4.1      No person shall be granted Options which would at the date they are
         granted cause the aggregate market value of the Shares which he may
         acquire under all Options granted under Part B of this Plan and all
         other shares which he may acquire pursuant to any option granted to him
         (and not exercised) under any other share option scheme, not being a
         savings-related scheme, approved under Schedule 9 and established by
         the Company or any Associated Company to exceed or further exceed
         (pound)30,000 or such other limit imposed from time to time under
         paragraph 28(1) of Schedule 9.

4.2      In calculating market values for the purpose of this Rule, the
         calculation shall be by reference to the market value of shares as at
         the time an option was granted as determined in accordance with the
         rules of the relevant share option scheme.

5.       VARIATIONS IN SHARE CAPITAL

5.1      ADJUSTMENT OF OPTIONS

                                                                              15
<PAGE>   18

         Subject to Rule 5.2 below, in the event (a "Relevant Event") of any
         variation in the equity share capital of the company in consequence of
         a capitalisation or rights issue, sub-division, consolidation or
         reduction of share capital or other variation in the share capital:

         5.1.1    the number or nominal amount of  Shares comprised in each
                  Option, and/or

         5.1.2    the Option Price, and/or

         5.1.3    the aggregate Option Price in relation to any Option

         may be adjusted in such manner as the Directors consider appropriate
         (including retrospective adjustments where such Relevant Event or the
         variation in the equity share capital of the Company as a consequence
         of the Relevant Event occurs after the Option Exercise Date but the
         relevant record date precedes such Option Exercise Date). If and to the
         extent a Relevant Event is a change in the number or kind of Shares
         effected solely by application of a mathematical formula (e.g., a
         2-for-1 stock split), the adjustment described in this Rule 5.1 shall
         be made and shall occur automatically by application of such formula,
         without further action by the Directors.

5.2      UK INLAND REVENUE APPROVAL TO ADJUSTMENTS

         At a time when Part B of the Plan is approved by the UK Inland Revenue
         under Schedule 9, no adjustment under Rule 5.1 above shall be made to
         an Option granted under Part B without the prior approval of the UK
         Inland Revenue.

5.3      NOTICE

         The Directors may take such steps as they consider necessary to notify
         Option Holders of any adjustment made under this Rule 5.

6.       EXERCISE AND LAPSE - GENERAL RULES

6.1      EXERCISE - GENERAL RULES

         Unless otherwise specified in these Rules an Option shall only be
         exercisable:

         6.1.1    on or after the third anniversary of the Date of Grant
                  (subject to Rule 7 applying);

         6.1.2    on the satisfaction or waiver of any condition imposed under
                  Rule 2.3;

         6.1.3    except as provided in Rule 7, while the Option Holder is a
                  full-time Director or an employee of a Member of the Group;
                  and

         6.1.4    in such periods (if any) as are specified by the Board and the
                  time the option is granted.

6.2      LAPSE

         Subject to Rule 7.3, Options shall lapse on the expiry of the Option
         Period.

7.       CESSATION OF EMPLOYMENT

7.1      GENERAL RULE

                                                                              16
<PAGE>   19

         If an Option Holder ceases to be a director or employee of any Member
         of the Group (except for any reason specified in Rule 7.2 below), then:

         7.1.1    All Options granted less than 3 years before cessation shall
                  lapse and determine upon such cessation; and

         7.1.2    All other Options shall be exercisable within 6 months of such
                  cessation (but not after the expiry of the Option Period) and
                  if not so exercised shall lapse and determine.

7.2      CESSATION OF EMPLOYMENT - SPECIAL CASES

         If an Option Holder ceases to be a director or employee of any Member
         of Group:-

         7.2.1    by reason of retirement; or

         7.2.2    by reason of injury, disability or dismissal for redundancy,
                  or by reason only that his office or employment is in a
                  Company which ceases to be a Member of the Group, or relates
                  to a business or part of a business which is transferred to a
                  person, who is not a Member of the Group; or

         7.2.4    by reason of death then the Option shall become exercisable
                  and may be exercised by the Option Holder (or his personal
                  representatives if appropriate) to the extent permitted by
                  this Rule 7.3 in and within the exercise period as set out in
                  Rule 7.4.

         For the purposes of this Rule 7.2, whether an Option Holder has ceased
         to be a director or employee of any Member of the Group by reason of
         retirement, injury, disability or dismissal for redundancy shall be
         determined by the Directors, whose decision or such matter shall be
         final and binding.

7.3      The extent to which an Option shall become exercisable and may be
         exercised in accordance with this Rule is that one sixth of the Option
         can be exercised for each full period of six months for the Date of
         Grant until the relevant cessation of employment during which the
         Option Holder was a director or employee of a Member of the Group.

7.4      The exercise period referred to at Rule 7.2 above is:

         7.4.1    in the case of death, the period of 12 months from the date of
                  death

         7.4.2    in all other circumstances considered in Rule 7.2, the period
                  which shall expire 6 months after his so ceasing or 42 months
                  after the Grant Date, whichever shall be the later

         provided that no Option can be exercised after the expiry of the Option
         Period.

7.5      LEAVE OF ABSENCE

         No Options that are not exercisable at the beginning of an authorised
         leave of absence shall become exercisable during such leave of absence.

7.6      TAKE-OVERS ETC.

         7.6.1    Subject to Rule 7.4.4 below if, in consequence of any offer
                  made to the holders of Shares, the Directors become aware that
                  the right to cast more than 50 per cent of the

                                                                              17
<PAGE>   20

                  votes which may ordinarily be cast on a poll at a general
                  meeting of the Company has or will become vested in the
                  offeror and/or any company controlled by the offeror and/or
                  any person associated with or acting in concert with the
                  offeror, the Directors shall, within 30 days of becoming so
                  aware, notify every Option Holder accordingly.

         7.6.2    Each Option Holder shall be entitled at any time during the
                  Change of Control Period to exercise all his Options (whether
                  or not otherwise exercisable) in whole or in part. The Options
                  shall not lapse on the expiry of the Change of Control Period
                  but all Options not exercisable immediately prior to the
                  beginning of the Change of Control Period shall cease to be
                  exercisable on the expiry of the Change of Control Period.

         7.6.3    For the purposes of this Rule 7, "Change of Control Period"
                  means the period commencing on the date of the giving of the
                  Directors' notification under this Rule 7.6 and ending three
                  months after that.

         7.6.4    Unless the Directors decide otherwise, the provisions of this
                  Rule 7.6 shall not apply if an Original Shareholder shall
                  become entitled to cast more than 50% of the votes which may
                  ordinarily be cast on a poll at a general meeting of the
                  Company.

7.7      WINDING UP

         In the event of the proposed dissolution or liquidation of the Company,
         all outstanding Options will terminate immediately prior to the
         consummation of such proposed action, unless otherwise provided by the
         Option Committee; provided, however, that if the rights of an Option
         Holder (or his personal representatives if appropriate) have not
         otherwise terminated and expired, the Option Holder (or his personal
         representatives if appropriate) will have the right immediately prior
         to such dissolution or liquidation to exercise any Option to the extent
         that the Option is exercisable as of the date immediately prior to such
         dissolution or liquidation, and the Option Committee may, in the
         exercise of its sole discretion in such instance, accelerate the date
         on which any Option becomes exercisable or fully vests and/or declare
         that any Option shall terminate as of a specified date.

7.8      LOSS OF OWNERSHIP

         Where the Option Holder is deprived of the legal or beneficial
         ownership of the Option by operation of law, or does anything or omits
         to do anything which causes him to be so deprived or becomes bankrupt,
         all his Options shall lapse.

7.9      OVERSEAS TRANSFER

         If an Option Holder, whilst continuing to hold an office or employment
         with a Member of the Group is transferred to work in another country
         and as a result of that transfer the Option Holder will either:

         7.7.1    become subject to tax on his remuneration in the country to
                  which he is transferred and the Option Committee are satisfied
                  that as a result he will suffer a tax disadvantage upon
                  exercising an Option; or

         7.7.2    become subject to restrictions on his ability to exercise his
                  Option or to hold or deal in the Shares or the proceeds of the
                  sale of the Shares he may acquire upon the

                                                                              18
<PAGE>   21
                  exercise of that Option by reason of or in consequence of the
                  security laws or exchange control laws of the country to which
                  he is transferred;

         the Option Committee (or its delegate) may allow the Option Holder to
         exercise the Option in a period specified by the Committee or its
         delegate. The Options will become exercisable again in the ordinary
         course if not so exercised.

7.10     PRIORITY

         In the event of any conflict between any of the provisions of Rules 6
         and 7, the provision which results in the earliest lapsing of the
         Option in question shall prevail.

8.       EXERCISE OF OPTION

8.1      LIMIT ON EXERCISE

         An Option may only be exercised during the periods specified in Rules 6
         and 7.

8.2      MANNER OF EXERCISE

         To exercise an Option in whole or in part, an Option Holder must
         deliver to the Secretary of the Company or other duly appointed agent:

         8.2.1    the option certificate covering the Shares over which the
                  Option is being exercised;

         8.2.2    notice in writing, in the prescribed form, duly completed and
                  signed by the Option Holder or by his duly appointed agent;
                  and

         8.2.3    payment in full of the Option Price for the total number of
                  Shares in respect of which the Option is being exercised.

         The Option Holder shall pay the Option Price for a Option as specified
         by the Option Committee (x) in cash or (y) by such other method as the
         Option Committee may approve, including, but not limited, to cashless
         exercise procedures.

8.3      TRANSFER

         Subject to Rules 8.5 and 8.6, the Directors shall allot the Shares to
         be issued or shall procure the transfer of Shares to be transferred
         following the exercise of an Option within 30 days of the Option
         Exercise Date.

8.4      RIGHTS

         In respect of Shares issued or transferred on the exercise of an
         Option, Option Holders are entitled to all rights attaching to such
         Shares by reference to a record date after the Option Exercise Date.
         They shall not be entitled to rights before such date.

8.5      CONSENTS

         All allotments, issues and transfers of Shares will be subject to any
         necessary consents or other applicable requirements or restrictions
         under any relevant enactment or regulations for the time being in force
         in the United Kingdom and the United States or elsewhere, and it shall
         be the responsibility of the Option Holder to comply with any
         requirements to be fulfilled in order to obtain or obviate the
         necessity for any such consent.

                                                                              19
<PAGE>   22
8.6      TAX WITHHOLDING

         In a case where a Member of the Group is obliged to (or would suffer a
         disadvantage if it were not to) account for any tax (in any
         jurisdiction) for which the person exercising an Option is liable by
         virtue of the exercise of the Option and/or for any social security
         contributions recoverable from the person in question (together, the
         "Tax Liability"), no Shares shall be issued or transferred following
         the exercise of an Option unless that person has either:

         (i)    made a payment to the Member of the Group of an amount equal
                to the Tax Liability; or

         (ii)   entered into arrangements acceptable to that or other Member
                of the Group to secure that such payment is made (whether by
                authorising the sale of some or all of the shares on his
                behalf and the payment to the Member of the Group of the
                relevant amount of the proceeds of sale or otherwise).

8.7      ARTICLES OF ASSOCIATION

         Any Shares acquired upon the exercise of Options shall be subject to
         the Articles of Incorporation and the By-Laws of the Company from time
         to time in force.

8.8      UK INLAND REVENUE REQUIREMENTS

         8.8.1  An Option Holder shall not be eligible to exercise an Option
                at any time when he is not eligible to participate in this
                Part B of the Plan by virtue of paragraph 8 of Schedule 9
                (material interest in a close company).

         8.8.2  The Shares transferred to an Option Holder following the
                exercise of an Option shall meet the requirements of paragraphs
                10 to 14 of Schedule 9 (fully paid up, unrestricted, ordinary
                share capital).

9.       GENERAL

9.1      Notices

         Any notice or other document required to be given under or in
         connection with the Plan may be delivered to an Option Holder or sent
         by post to him at his home address according to the records of his
         employing company or such other address as may appear to the Company to
         be appropriate. Notices sent by post shall be deemed to have been given
         on the day following the date of posting. Any notice or other document
         required to be given to the Company under or in connection with the
         Plan may be delivered or sent by post to it at its registered office
         (or such other place or places as the Directors may from time to time
         determine and notify to Option Holders).

9.2      AVAILABILITY OF SHARES

                                                                              20
<PAGE>   23

         The Company shall procure that sufficient Shares are available for
         transfer or issue to satisfy all Options under which Shares may be
         acquired.

9.3       DIRECTORS' DECISIONS FINAL AND BINDING

         The decision of the Directors in any dispute relating to an Option or
         matter relating to the Plan shall be final and conclusive.

9.4      COSTS

         The costs of introducing and administering the Plan shall be borne by
         the Company.

9.5      REGULATIONS

         The Directors shall have the power from time to time to make or vary
         regulations for the administration and operation of the Plan provided
         that the same are not inconsistent with these Rules.

9.6      LIMITATIONS OF LIABILITY

         The rights and obligations of an Option Holder under the terms and
         conditions of his office or employment shall not be affected by his
         participation in the Plan or any right he may have to participate in
         the Plan. An individual who participates in the Plan waives all and any
         rights to compensation or damages in consequence of the termination of
         his office or employment with any company for any reason whatsoever
         insofar as those rights arise, or may arise, from his ceasing to have
         rights under or be entitled to exercise any Option under the Plan as a
         result of such termination or from the loss or diminution in value of
         such rights or entitlements. If necessary the Option Holder's terms of
         employment shall be varied accordingly.

9.7      NOTIFICATION TO UK INLAND REVENUE

         If the Company operates the Scheme as an Employees' Share Plan which is
         not approved by the UK Inland Revenue, the Company will inform the UK
         Inland Revenue.

10.      AMENDMENTS AND TERMINATION

10.1     DIRECTORS' POWERS OF AMENDMENT

         10.1.1   Subject to Rule 10.1.2, the Directors may at any time alter or
                  add to all or any of the provisions of this Part B of the Plan
                  in any respect; provided that no such amendment shall
                  materially impair the rights of any Option Holder under any
                  previously granted Option unless the amendments is required by
                  applicable law, or

                  (i)   the Directors have invited every relevant Option Holder
                        to give an indication as to whether or not he approves
                        of the amendment; and

                  (ii)  the alteration is approved by the majority of those
                        Option Holders who have given such an indication.

         10.1.2   If an alteration which does not solely relate to an objective
                  condition relating to the performance of the Company imposed
                  under Rule 2.3 is made at a time when this Part B is approved
                  by the UK Inland Revenue under Schedule 9, the approval will
                  not

                                                                              21
<PAGE>   24

                  thereafter have effect unless and until the Inland Revenue
                  have approved the alteration.

10.2     OVERSEAS EMPLOYEES

         Notwithstanding any other provision of the Plan the Directors may, in
         respect of Options granted to Eligible Employees who are or who may
         become subject to taxation outside the United States on their
         remuneration, amend or add to the provisions of the Plan and the terms
         of Options as they consider necessary or desirable to take account of
         or to mitigate or to comply with relevant overseas taxation,
         securities, exchange control and/or other overseas laws, provided that
         the terms of Options granted to such Eligible Employees are not overall
         more favourable than the terms of Options granted to other Eligible
         Employees.

10.3     NOTICE

         As soon as reasonably practicable after making any alteration, the
         Directors shall give written notice to any Option Holder affected by
         the alteration or addition.

10.4     TERMINATION OF THE PLAN

         The Directors may terminate the Plan at any time, and it shall
         terminate on the 10th anniversary of its adoption by the Directors, but
         Options granted prior to such termination shall continue to be valid
         and exercisable in accordance with these Rules.

11.      GOVERNING LAW

         The Plan and all Options shall be governed by and construed in
         accordance with [applicable state] law.

                                                                              22
<PAGE>   25

                            SCHEDULE 1 - US ISO PLAN

     THE APBIOTECH STOCK OPTION PLAN 2000 - INCENTIVE STOCK OPTION SCHEDULE

This Schedule constitutes the US approved part of the APBiotech Stock Option
Plan 2000 (the "US ISO PLAN"). The terms of the US ISO Plan are identical to
Part A of the APBiotech Stock Option Plan 2000 (the "PLAN") to which the US ISO
Plan is appended except as follows:

1.       For purposes of the US ISO Plan, Options otherwise granted in
         accordance with Part A of the Plan may be designated as "Incentive
         Stock Options" ("ISOS") within the meaning of section 422 of the United
         States Internal Revenue Code of 1986, as amended (the "US TAX CODE").

2.       The aggregate number of Shares for which ISOs may be granted under the
         US ISO Plan shall not exceed 2,500,000. The price at which Shares may
         be acquired by the exercise of an Option under the US ISO Plan shall be
         not less than the Market Value of such Shares as of the Grant Date as
         determined by the Board.

3.       The class of persons who may receive ISOs shall, in addition to the
         limitations imposed by the Plan, be limited to those persons who are
         employees of the Company or its "parent" or "subsidiary" corporations
         within the meaning of sections 424(e) and (f), respectively, of the US
         Tax Code.

4.       In addition to any other restrictions contained in the Plan, ISOs shall
         not be transferable otherwise than by will or the laws of descent and
         distribution. During the lifetime of the person to whom the ISO is
         granted, the ISO shall be exercisable only by such person.

5.       To the extent that the aggregate market value of Shares with respect of
         which ISOs are exercisable for the first time by a Participant during
         any calendar year (under all plans or schemes of the Company or its
         "parent" and "subsidiary" corporations within the meaning of section
         424(e) and (f) respectively of the US Tax Code) exceed US$100,000, such
         Options shall to the extent of such excess be treated as Options which
         are not ISOs. For the purpose of the preceding sentence, the market
         value of any Shares subject to an ISO shall be determined at the time
         such ISO is granted.

6.       For purposes of any ISO grants, the terms of the Plan shall be deemed
         to be incorporated by reference in this Schedule.

7.       No Options may be granted as ISOs under the US ISO Plan after the
         earlier of the tenth anniversary of (a) the date of adoption of the US
         ISO Plan by the Board, or (b) the date the US ISO Plan is approved by
         the Company's Stockholders.

8.       If any Option is exercised in accordance with Rules 5 to 7 of the Plan
         more than three (3) months after the date the Participant was last
         employed by the Company (or by its parent or a subsidiary as defined in
         Rule 3 of this Schedule above), or in the case of either death or
         "total disability" (as defined by section 422(c)(6) of the US Tax Code)
         more than twelve (12) months after the date that the Participant was
         last employed by the Company (or by its parent or a subsidiary as
         defined in Rule 3 of this Schedule above), then such Option shall be
         treated as a non-qualified stock option for purposes of the US Tax
         Code.

                                                                              23
<PAGE>   26
 9.       If an Option is granted to an individual who, at the time the Option
         is granted, owns stock possessing more than 10% of the total combined
         voting power of all classes of stock of the Company (or its parent or
         any subsidiary as defined in Rule 3 of this Schedule above), then the
         Option exercise price shall be not less than 110% of the fair market
         value of the Shares which may be acquired by the exercise of the
         Option, and such option by its terms shall not be exercisable after the
         expiration of 5 years from the date such Option is granted.

                                                                              24
<PAGE>   27

                                   SCHEDULE 2

                                CASH OPTION PLAN

1.       RULES

         The Rules of the APBiotech Stock Option Plan 2000 Part A shall apply
         mutatis mutandis to a right ("Cash Option") to receive a cash sum
         granted or to be granted pursuant to this Schedule 2 as if it was an
         option to acquire existing shares in the Company, except as set out in
         this Schedule 2.

2.       RULE CHANGES

2.1      The Rules of Part A of the Plan shall be varied as set out below. Where
         any Rule is deleted, the other Rules shall be renumbered accordingly
         (including any cross references in Rules of Part A of the Plan).

2.2      Rule 7.2 ("Manner of Exercise") shall be deleted and replaced by the
         following Rule.

         "7.2 MANNER OF EXERCISE

         An Option shall be exercised in the form and manner prescribed by the
         Option Committee from time to time".

2.3      Rules 7.3, 7.4, 7.5 and 7.7 (transfer of shares on option exercise;
         right of shares; consents; articles of association) shall be deleted.

2.4      Rule 8.2 (Availability of Shares) shall be deleted.

3.       CASH OPTIONS

3.1      The Option Committee may grant or procure the grant of a Cash Option
         upon the terms set out below.

3.2      Each Cash Option shall be expressed to relate to a given number of
         Shares in the Company.

3.3      The amount of the cash sum to be paid to the Participant on the
         exercise of the Cash Option shall be equal to the amount by which the
         Exercise Value of the Shares over which the Cash Option is expressed to
         relate exceeds the Option Price, where the Exercise Value of a Share
         equals the Market Value of a Share (as calculated in accordance with
         Part A of the Plan) on the date of exercise of the Cash Option (or if
         that is not a dealing day, on the immediately prior dealing day) and
         where the Option Price is the price determined in accordance with Rule
         3.1 of Part A of the Plan.

3.4      The cash sum payable pursuant to paragraph 3.3 above shall be paid by
         the employer within 30 days of the exercise of the Cash Option, net of
         any deductions (on account of tax or similar liabilities) as may be
         required by law.

[4.      TRUST OPTIONS

                                                                              25
<PAGE>   28

3.5      Notwithstanding any other provisions of Part A of the Plan, where a
         Cash Option is granted, the Company may grant an Option ("a Trust
         Option") to subscribe for shares in the Company to the trustee of any
         employee trust if, prior to the grant of the Cash Option, the trustee
         agreed that if the Company gives notice to the trustee on the exercise
         of the Cash Option, the trustee will pay to or on behalf of the Company
         an amount equal to that payable to the person exercising the Cash
         Option as referred to in paragraph 3.3 above of this Schedule.

3.6      The terms of the Trust Option shall be as follows:

         (a)   The number of shares over which the Trust Option is granted shall
               be the same as that to which the Cash Option relates (and this
               number shall be adjusted accordingly in the event that the number
               of shares to which the Cash Option relates is adjusted).

         (b)   The price per share payable to the Company on the exercise of the
               Trust Option shall be the same as the Option Price applicable to
               the Cash Option (after any adjustment).

         (c)   The Trust Option shall be exercisable only if, on the exercise of
               the Cash Option, the Company gives notice to the trustee
               requiring the trustee to make a payment to or on behalf of the
               Company as aforesaid and then only in respect of the number of
               shares in respect of which the Cash Option is exercised.

         (d)   The Trust Option should be non-transferable other than to any
               successor trustee of the trust in question.]

                                                                              26
<PAGE>   29

                                     FRANCE

                             SCHEDULE 3 TO PART A TO
         THE AP BIOTECH OPTIONS FOR ALL PLAN 2000 - ("THE FRENCH PLAN")

This Schedule contains the terms of French Options granted under the AP Biotech
Stock Option Plan 2000 to Eligible Employees working in France - ("the French
Plan"). The terms of the French Plan are identical to the AP Biotech Stock
Option Plan 2000 Part A ("the Plan") to which the French Plan is appended except
as follows:

1.  For the purposes of any French Options, the terms of the Plan should be
    deemed incorporated by reference to this Schedule.

2.  For the purposes of the French Plan, Options granted in accordance with the
    French Plan ("French Options") may be designated as Qualifying French stock
    Options within the meaning of the conditions set forth in the French Company
    law (Loi 24 Juillet 1966 code Societes commerciales, articles 208-1 a
    208-8-2) ("French Company Law"), subject to amendment by the bill Projet de
    Loi relatif aux Regulations Economiques numero 2250 depose le 15 mars 2000
    (urgence declaree) before the Senate/National Assembly.

3.  The aggregate number of shares for which French Options may be granted under
    the French Plan shall not exceed one third of the Company's issued share
    capital from time to time.

4.  The exercise price of French Options shall not be less than 80% of the
    average quoted price of the shares on the NASDAQ during the 20 Business Days
    preceding the Date of Grant.

5.  No persons holding more than 10% of the issued share capital of the Company
    shall be eligible to participate under the French Plan.

6.  Subject to Clause 7 below, the definition of Eligible Employee in Rule 1.1
    of the Plan shall be amended as follows:

    "Eligible Employee means any person who is a common law employee of a
    Participating Company and who is based in France (but not a Director of the
    Company) who devotes substantially the whole of his working time to his
    duties".

7.  Only individuals who are based in France and have either an employment
    relationship with a Participating Company or hold one of the following
    offices [of the French Company] shall be eligible to be granted French
    Options: President Directuer General, Directuer General, Members of the
    "Directoire", "Gerint" of the "Societe en commandite par actions".

8.  In addition to any other restrictions contained in the Plan, French Options
    shall not be transferable otherwise on death. During the lifetime of the
    Option Holder to whom the French Option has been granted, the French Option
    shall only be exercisable by the Option Holder. On the death of the Option
    Holder, the Option Holders heirs may exercise his French Options within
    6 months following the Option Holders death.

9.  Rule 4 of the Plan shall only apply to French Options to the extent that
    such variations are permitted under French Company Law.

10. In the case of Options to acquire subsisting Shares the Company shall
    procure that sufficient Shares are available for transfer to satisfy the
    exercise of such Options (which have neither lapsed nor been exercised) to
    the full extent possible, taking into account any other obligations of the
    Company to provide shares of the same class as such Shares.

<PAGE>   30

11. Rule 3 of the Plan shall be limited as follows:

    (a)  No French Options may be granted before the end of the period of
         20 Business Days following a dividend distribution or capital
         increase or before or after 10 Trading Days of the publication of
         consolidated or, if none, annual accounts or between the date that
         company officers have knowledge of a significant event which would
         affect the value of the share and 10 trading days after the event
         has been publicised.;

    (b)  With respect to Options to subscribe for newly issued Shares
         Options may not be granted during any other period prohibited by
         French law.

12. In accepting the grant of the French Option the Option Holder undertakes
    that he will advise the Company of the date on which the Option is
    exercised and the date on which the shares are sold within 14 days of
    either event.

13. An exercise of French Options in accordance  with Rule 4 of the Plan shall
    be permitted  until the later of 6 months of the Option Holder ceasing to
    be employed or 42 months after the Date of Grant.

14. The French Options shall not be ordinarily capable of exercise before
    the third anniversary of the Date of Grant or such earlier date as may
    be determined by the Company at any time before the date when the
    French Option would otherwise first become capable of being exercised.

15. In the case of Options to acquire treasury stock the Company must deliver
    to the Option Holder on exercise, Shares which have already been acquired
    not more than 12 months prior to the date on which the French Options first
    became exercisable. Any Treasury Stock to be used to satisfy the exercise
    of French Options shall be kept separate and identifiable and shall be held
    in a defined French Share account (Instruction du 6 mai 1988 4 N 3 88).

<PAGE>   31

AP Biotech

                           SCHEDULE 4 TO PART A TO THE
                      AP BIOTECH OPTIONS FOR ALL PLAN 2000

This Schedule 4 contains the terms of Options ("Italian Options") granted under
the AP Biotech Options For All Plan 2000 to eligible employees working in Italy
- ("the Italian Plan"). The terms of the Italian Plan are identical to the AP
Biotech Options For All Plan 2000 Part A ("the Plan") to which the Italian Plan
is appended except as follows:

1.   The exercise price of the Italian Options shall not be less than the
     Normal Value of the Shares at the Date of Grant. Normal Value is defined as
     the average settlement price on the NASDAQ during the period of the 30 days
     preceding the Grant Date (article 9, paragraph 4, Italian Tax Code). If
     the Company has been listed on the NASDAQ stock exchange for less than
     30 days prior to grant of Italian Options, then Normal Value will be the
     average value for the period of the listing.

2.   The shares  allocated to any  participant of the Plan shall not exceed 10%
     of the share capital or voting rights of the Company.

3.   The definition of Eligible Employee in Rule 1.1 of the Plan shall be
     amended as follows: "Eligible Employee means any person who is a common
     law employee of the Participating Company and who is based in Italy (but
     not a Director of the Company) who devotes substantially the whole of his
     working time to his duties"

<PAGE>   32

AP Biotech

                           SCHEDULE 5 TO PART A TO THE
                      AP BIOTECH OPTIONS FOR ALL PLAN 2000
                              - ("THE DUTCH PLAN")

This Schedule 5 contains the terms of Options ("Dutch Options") granted under
the AP Biotech Options For All Plan 2000 to Eligible Employees working in the
Netherlands - ("the Dutch Plan"). The terms of the Dutch Plan are identical to
the AP Biotech Options For All Plan 2000 Part A ("the Plan") to which the Dutch
Plan is appended except as follows:

1.   The exercise price of Dutch Options shall not be less than the Market Value
     of the Shares at the Date of Grant.

2.   The Option Period in relation to Dutch Options is confirmed as the period
     commencing on the Date of Grant and expiring at the close of business on
     the day preceding the 10th anniversary of the Date of Grant and in
     accordance with Dutch wage and income tax law the employee may elect to
     defer taxation until the date of exercise provided such election is made
     before the third anniversary of the Date of Grant. The Eligible Employee
     shall notify his Participating Company before the third anniversary of the
     Grant Date if such an election is made.

3.   The definition of Eligible Employee in Rule 1.1 of to the Plan shall be
     amended as follows: "Eligible Employee means any person who is a common
     law employee of a Participating Company and who is based in the Netherlands
     (but not a Director of the Company) who devotes substantially the whole of
     his working time to his duties"

<PAGE>   33

AP Biotech

                           SCHEDULE 6 TO PART A TO THE
                      AP BIOTECH OPTIONS FOR ALL PLAN 2000

This Schedule 6 contains the terms of Options ("Austrian Options") granted under
the AP Biotech Options For All Plan 2000 to Eligible Employees working in
Austria- ("the Austrian Plan"). The terms of the Austrian Plan are identical to
the AP Biotech Options For All Plan 2000 Part A ("the Plan") to which the
Austrian Plan is appended except as follows:

1.   The definition of Eligible Employee in Rule 1.1 of to the Plan shall be
     amended as follows: "Eligible Employee means any person who is a common
     law employee of a Participating Company and who is based in Austria (but
     not a Director of the Company) who devotes substantially the whole of his
     working time to his duties".

2.   In accepting the Grant of Austrian Options, the Option Holder undertakes
     that Shares acquired on exercise of Austrian Options shall be deposited
     with an Austrian bank.

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