Document:

Incremental Facility Amendment and Amendment No. 3 dated as of November 15, 2005

 Exhibit 10.1 
 INCREMENTAL FACILITY AMENDMENT AND AMENDMENT NO. 3 (this “Amendment”) dated as of July 10, 2006, to the CREDIT
AGREEMENT dated as of August 20, 2004, as amended as of March 17, 2005, and November 15, 2005 (the “Credit Agreement”), among US ONCOLOGY HOLDINGS, INC., a Delaware corporation (“Holdings”), US
ONCOLOGY, INC., a Delaware corporation (the “Borrower”), the LENDERS party thereto, JPMORGAN CHASE BANK, N.A., as Administrative Agent and Collateral Agent, WACHOVIA BANK, NATIONAL ASSOCIATION, as Syndication Agent, and CITICORP
NORTH AMERICA, INC., as Documentation Agent. 
 A. Pursuant to the Credit Agreement, the Lenders and the Issuing Banks (such terms and each
other capitalized term used but not defined herein having the meaning assigned to such term in the Credit Agreement (as amended hereby)) have extended credit to the Borrower, and have agreed to extend credit to the Borrower, in each case pursuant to
the terms and subject to the conditions set forth therein. 
 B. The Borrower has requested that the Lenders agree to amend certain provisions
of the Credit Agreement as set forth herein. 
 C. The undersigned Lenders are willing to so amend the Credit Agreement pursuant to the terms
and subject to the conditions set forth herein. 
 D. Pursuant to Section 2.20 of the Credit Agreement, the Borrower has further
requested that the Incremental Lenders provide an Incremental Extension of Credit to the Borrower under the Credit Agreement in an aggregate principal amount of $100,000,000. 
 E. The Incremental Lenders are willing to provide such Incremental Extension of Credit to the Borrower pursuant to the terms and subject to the
conditions set forth herein. 
 F. J.P. Morgan Securities Inc. and Wachovia Capital Markets, LLC will act as co-lead arrangers and joint
bookrunners in respect of such Incremental Extension of Credit. 
 Accordingly, in consideration of the mutual agreements herein contained
and other good and valuable consideration, the sufficiency and receipt of which are hereby acknowledged, and subject to the conditions set forth herein, the parties hereto hereby agree as follows: 
 SECTION 1. Defined Terms. As used in this Amendment, the following terms have the meanings specified below: 
 “Amendment Transactions” means the execution and delivery of this Amendment and the Reaffirmation Agreement (as defined
in Section 18 hereof) by each Person party hereto or thereto, the satisfaction of the conditions to the effectiveness hereof and thereof and the consummation of the transactions contemplated hereby and thereby. 

 “Incremental Effective Date” shall mean July 10, 2006,
provided that all the conditions set forth or referred to in Sections 18 hereof shall have been satisfied (or waived by each of the Incremental Lenders) on such date. 
 “Incremental Lenders” means the Persons listed on Schedule 1 hereto. 
 “Tranche C Commitment” means, with respect to each Incremental Lender, the commitment of such Incremental Lender to make
a Tranche C Term Loan hereunder on the Incremental Effective Date, expressed as an amount representing the maximum principal amount of the Tranche C Term Loan to be made by such Incremental Lender hereunder, as set forth on Schedule 1 hereto.
The aggregate amount of the Tranche C Commitments of all Incremental Lenders as of the date of this Amendment will be $100,000,000. 
 SECTION 2. Commitment. Subject to the terms and conditions set forth herein, each Incremental Lender agrees to make a Tranche C Term Loan to the Borrower on the Incremental Effective Date in a principal amount not exceeding such
Incremental Lender’s Tranche C Commitment. The funding of the Tranche C Term Loans on the Incremental Effective Date shall be consummated at a closing to be held at the offices of Cravath, Swaine & Moore LLP, or at such other place as
the Borrower and the Administrative Agent shall agree upon. Unless previously terminated, the Tranche C Commitments shall terminate at 5:00 p.m., New York City time, on the Incremental Effective Date. 
 SECTION 3. Amendments to Section 1.01. (a) Section 1.01 of the Credit Agreement is hereby amended by adding the following
definitions in the appropriate alphabetical order: 
 “Consolidated Assets” means, as of any date, the total
assets of the Borrower and the Subsidiaries, determined in accordance with GAAP, as set forth in the most recent Financial Officer’s certificate delivered pursuant to Section 5.01(c). 
 “Incremental Effective Date” has the meaning set forth in Section 1 of the Tranche C Facility Amendment. 

“Tranche C Facility Amendment” means the Incremental Facility Amendment and Amendment No. 3 dated as of
July 10, 2006, among Holdings, the Borrower, the Lenders party thereto and the Administrative Agent. 
 “Tranche
C Commitment” has the meaning set forth in Section 1 of the Tranche C Facility Amendment. 
 “Tranche C
Maturity Date” means August 20, 2011. 
 “Tranche C Term Loan” means a Loan made pursuant to
Section 2 of the Tranche C Facility Amendment. 
 (b) The definition of the term “Applicable Rate” in Section 1.01
of the Credit Agreement is hereby amended by (i) inserting the text “or Tranche C Term Loan” immediately 
  

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 following the text “Tranche B Term Loan” in clause (b) of the first paragraph of such definition,
(ii) inserting the text “, “Tranche C Term Loan ABR Spread”, “Tranche C Term Loan Eurodollar Spread”“ immediately following the text “Tranche B Term Loan Eurodollar Spread” in clause (c) of the first
paragraph of such definition and (iii) deleting the second pricing table contained therein in its entirety and inserting the following table set forth below: 
  

													
	 Leverage Ratio:
	  	Tranche B
Term Loan
ABR Spread	 	 	Tranche B Term
Loan Eurodollar
Spread	 	 	 Tranche C
 Term Loan
ABR Spread
	 	 	Tranche C Term
Loan Eurodollar
Spread	 
	 Greater than or equal to 3.50 to 1.00
	  	1.25	%	 	2.25	%	 	1.25	%	 	2.25	%
	 Less than 3.50 to 1.00
	  	1.00	%	 	2.00	%	 	1.00	%	 	2.00	%

 (c) The definition of the term “Class” in Section 1.01 of the Credit
Agreement is hereby amended by (i) inserting the text “, Tranche C Term Loans” immediately following the text “Tranche B Term Loans”, (ii) replacing “or a” in the fourth line of such definition with
“,” and (iii) inserting the text “or Tranche C Commitment” immediately following the text “Tranche B Commitment”. 
 (d) The definition of the term “Excess Cash Flow” in Section 1.01 of the Credit Agreement is hereby amended by inserting the text “and Tranche C Term Loans” immediately following the
text “Tranche B Term Loans” in clause (f) thereof. 
 (e) The definition of the term “Funded Debt” in
Section 1.01 of the Credit Agreement is hereby amended by inserting the text “and Tranche C Term Loans, in each case” immediately following the text “Tranche B Term Loans”. 
 (f) The definition of the term “Interest Election Request” in Section 1.01 of the Credit Agreement is hereby amended by
(i) replacing “or a” in the second line of such definition with “,” and (ii) inserting the text “or Tranche C Term Borrowing” immediately following the text “Tranche B Term Borrowing”. 
 (g) The definition of the term “Leverage Ratio” in Section 1.01 of the Credit Agreement is hereby amended by inserting the text
“and Tranche C Term Loans” immediately following each occurrence of the text “Tranche B Term Loans”. 
 (h) The
definition of the term “Unused Equity Net Proceeds” in Section 1.01 of the Credit Agreement is hereby amended by inserting the text “and Tranche C Term Borrowings” immediately following the text “Tranche B Term
Borrowings”. 
 SECTION 4. Amendment to Section 2.02. Section 2.02 of the Credit Agreement is hereby amended as
follows: 
 (a) by amending clause (b) thereof by (i) replacing “and” in the first line thereof with “,” and
(ii) inserting the text “and Tranche C Term Borrowing” immediately following the text “Tranche B Term Borrowing”. 
  

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 (b) by amending clause (d) thereof by (i) replacing “or the” in the fourth line
thereof with “,” and (ii) inserting the text “or Tranche C Maturity Date” immediately following the text “Tranche B Maturity Date”. 
 SECTION 5. Amendment to Section 2.05. Section 2.05(b) is hereby amended by replacing clause (i) thereof with the following text: “(i) the LC Exposure shall not exceed $75,000,000 and”

 SECTION 6. Amendment to Section 2.07. Section 2.07 of the Credit Agreement is hereby amended by (i) replacing
“and” in the first line thereof with “,” and (ii) inserting the text “and Tranche C Term Borrowing” immediately following the text “Tranche B Term Borrowing”. 
 SECTION 7. Amendment to Section 2.09. Section 2.09 of the Credit Agreement is hereby amended by replacing “and (iii)” in the
sixth line thereof with “, (iii) to the Administrative Agent for the account of each Additional Lender the then unpaid principal amount of each Tranche C Term Loan of such Additional Lender as provided in Section 2.10 and (iv)”.

 SECTION 8. Amendments to Section 2.10. Section 2.10 of the Credit Agreement is hereby deleted in its entirety and
replaced with the following text, which, with respect to Tranche B Term Borrowings, reflects prepayments of Tranche B Term Borrowings made prior to the date hereof: 
 “(a) Subject to adjustment pursuant to paragraph (c) of this Section, the Borrower shall repay Tranche B Term Borrowings and Tranche C Term Borrowings on each date set forth below in the aggregate
principal amount set forth opposite such date in the table below for the Tranche B Term Borrowings and Tranche C Term Borrowings (in each case, as adjusted from time to time pursuant to Section 2.10(c)), respectively: 
 Tranche B Term Borrowings 
  

				
	 Date
	  	Amount
	 June 30, 2007
	  	$	974,518.66
	 September 30, 2007
	  	 	974,518.66
	 December 31, 2007
	  	 	974,518.66
	 March 31, 2008
	  	 	974,518.66
	 June 30, 2008
	  	 	974,518.66
	 September 30, 2008
	  	 	974,518.66
	 December 31, 2008
	  	 	974,518.66
	 March 31, 2009
	  	 	974,518.66
	 June 30, 2009
	  	 	974,518.66
	 September 30, 2009
	  	 	974,518.66
	 December 31, 2009
	  	 	974,518.66
	 March 31, 2010
	  	 	974,518.66
	 June 30, 2010
	  	 	974,518.66
	 September 30, 2010
	  	 	91,604,754.43

  

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	 Date
	  	Amount
	 December 31, 2010
	  	91,604,754.43
	 March 31, 2011
	  	91,604,754.43
	 August 20,2011
	  	91,604,754.43

 Tranche C Term Borrowings 
  

				
	 Date
	  	Amount
	 June 30, 2007
	  	$	257,069.41
	 September 30, 2007
	  	 	257,069.41
	 December 31, 2007
	  	 	257,069.41
	 March 31, 2008
	  	 	257,069.41
	 June 30, 2008
	  	 	257,069.41
	 September 30, 2008
	  	 	257,069.41
	 December 31, 2008
	  	 	257,069.41
	 March 31, 2009
	  	 	257,069.41
	 June 30, 2009
	  	 	257,069.41
	 September 30, 2009
	  	 	257,069.41
	 December 31, 2009
	  	 	257,069.41
	 March 31, 2010
	  	 	257,069.41
	 June 30, 2010
	  	 	257,069.41
	 September 30, 2010
	  	 	24,164,524.42
	 December 31, 2010
	  	 	24,164,524.42
	 March 31, 2011
	  	 	24,164,524.42
	 August 20,2011
	  	 	24,164,524.42

 (b) To the extent not previously paid (i) all Tranche B Term Loans shall be due and
payable on the Tranche B Maturity Date and (ii) all Tranche C Term Loans shall be due and payable on the Tranche C Maturity Date. 
 (c) Any prepayment of a Tranche B Term Borrowing or Tranche C Term Borrowing shall be allocated between the Tranche B Term Borrowings and Tranche C Term Borrowings ratably in accordance with the respective principal amounts outstanding
thereof and applied (i) first, to reduce, in the direct order of maturity, the scheduled repayments of the Tranche B Term Borrowings and Tranche C Term Borrowings, respectively, to be made pursuant to this Section on the four consecutive
scheduled payment dates next following the date of such prepayment unless and until each such scheduled repayment has been eliminated as a result of reductions hereunder and (ii) second, to reduce ratably to the remaining scheduled repayments
of the Tranche B Term Borrowings and Tranche C Term Borrowings, respectively.” 
 SECTION 9. Amendments to
Section 2.11. Section 2.11 of the Credit Agreement is hereby amended as follows: 
 (a) by amending clause (a) thereof by
inserting the following proviso at the end thereof: “, provided that each prepayment of Tranche B Term Borrowings and Tranche C Term Borrowings pursuant to this paragraph shall be allocated between the Tranche B Term Borrowings and
Tranche C Term Borrowings ratably in accordance with the respective principal amounts outstanding thereof.” 
  

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 (b) by amending clause (c) thereof by (i) inserting the text “and, commencing on the
Incremental Effective Date, Tranche C Term Borrowings,” immediately following the text “Tranche B Term Borrowings” and (ii) by inserting a new sentence at the end thereof as follows: “Each prepayment pursuant to this
paragraph shall be allocated between the Tranche B Term Borrowings and Tranche C Term Borrowings ratably in accordance with the respective principal amounts outstanding thereof.” 
 (c) by amending clause (d) thereof by (i) inserting the text “and, commencing with the fiscal year ending December 31, 2006, Tranche
C Term Borrowings,” immediately following the text “Tranche B Term Borrowings”, (ii) inserting the text “and Tranche C Term Loans” immediately following each occurrence of the text “Tranche B Term Loans” and
(iii) inserting the text “(x) allocated between the Tranche B Term Borrowings and Tranche C Term Borrowings ratably in accordance with the respective principal amounts outstanding thereof and (y)” immediately after the text “Each
prepayment pursuant to this paragraph shall be” in the last sentence thereof. 
 SECTION 10. Amendment to Section 2.16.
Section 2.16 of the Credit Agreement is hereby amended by (i) replacing the second occurrence of the text “or” in clause (c) thereof with “,” and (ii) inserting the text “and Tranche C Term Loan”
immediately following the text “Tranche B Term Loan”. 
 SECTION 11. Amendment to Section 2.18. Section 2.18(c) of
the Credit Agreement is hereby amended by inserting the text “, Tranche C Term Loans” immediately following each occurrence of the text “Tranche B Term Loans” in clause (c) thereof. 
 SECTION 12. Amendment to Section 6.01. Section 6.01(a) of the Credit Agreement is hereby amended as follows: 
 (a) by inserting the text “and Tranche C Term Loans” immediately following each occurrence of the text “Tranche B Term Loans” in
clauses (xiii), (xiv) and (xix) thereof. 
 (b) by (i) replacing the text “Guarantees by the Borrower of Indebtedness of
any Subsidiary and by any Subsidiary of Indebtedness of the Borrower or any other Subsidiary” in clause (vii) thereof with the text “Guarantees by the Borrower of Indebtedness or other obligations of any Subsidiary and by any
Subsidiary of Indebtedness or other obligations of the Borrower or any other Subsidiary” and (ii) replacing clause (vii)(B) thereof with the following text: “Guarantees by the Borrower or any Subsidiary Loan Party of Indebtedness
or other obligations of any Subsidiary that is not a Loan Party shall be subject to Section 6.04”. 
 SECTION 13. Amendment to
Section 6.04. Section 6.04 is hereby amended by replacing the text “shall not exceed $50,000,000 in any fiscal year and $100,000,000 in the aggregate” in clause (i) thereof with the following text: “shall not exceed
$150,000,000 in any fiscal year and $250,000,000 in the aggregate”. 
  

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 SECTION 14. Amendment to Section 6.08. Section 6.08(a)(x) of the Credit Agreement is
hereby amended by inserting the text “and Tranche C Term Borrowings” immediately following the text “Tranche B Term Borrowings”. 
 SECTION 15. Amendment to Section 9.02. Section 9.02(b) of the Credit Agreement is hereby amended as follows: 
 (a) by amending clause (iii) of the first proviso thereof by inserting the text “or Tranche C Term Loan” immediately following the text “Tranche B Term Loan”. 
 (b) by replacing clause (B) of the second proviso thereof with the following text: “(B) any waiver, amendment or modification of this Agreement
that by its terms affects the rights or duties under this Agreement of the Revolving Lenders (but not the Tranche B Lenders or Additional Lenders), the Tranche B Lenders (but not the Revolving Lenders or Additional Lenders) or Additional
Lenders (but not the Revolving Lenders or Tranche B Lenders) may be effected by an agreement or agreements in writing entered into by Holdings, the Borrower and requisite percentage in interest of the affected Class of Lenders that would be required
to consent thereto under this Section if such Class of Lenders were the only Class of Lenders hereunder at the time”. 
 (c) by
inserting the text “, Tranche C Term Loans” immediately following each occurrence of the text “Tranche B Term Loans” in the last sentence thereof. 
 SECTION 16. Amendment to Section 9.03. Section 9.03(c) of the Credit Agreement is hereby amended by inserting the text “, outstanding Tranche C Term Loans” immediately following the text
“Tranche B Term Loans”. 
 SECTION 17. Amendment to Section 9.04. Section 9.04(b) of the Credit Agreement is
hereby amended by inserting the text “or Tranche C Term Loan” immediately following each occurrence of the text “Tranche B Term Loan”. 
 SECTION 18. Conditions to Funding. The obligations of the Incremental Lenders to make the Tranche C Term Loans hereunder shall not become effective until the date on which each of the following conditions is
satisfied: 
 (a) The Administrative Agent (or, in the case of clause (ii) below, its counsel) shall have received (i) from the
Borrower, at or prior to the time required by Section 2.03 of the Credit Agreement, a Borrowing Request with respect to the Borrowing of the Tranche C Term Loans (A) that complies with the requirements of Section 2.03 of the Credit
Agreement (treating each reference in such Section to a “Tranche B Term Borrowing” as a reference to a Tranche C Term Borrowing for purposes of this paragraph) and (B) pursuant to which the Borrower agrees that the provisions of
Section 2.16 of the Credit Agreement shall apply to any failure by the Borrower to borrow the Tranche C Term Loans on the Incremental Effective Date and (ii) from each of the Borrower and the Incremental Lenders party hereto, either
(A) a counterpart of this Amendment signed on behalf of such party or (B) written evidence satisfactory to the Administrative Agent (which may include telecopy transmission of a signed signature page of this Amendment) that such party has
signed a counterpart of this Amendment. 
  

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 (b) The Administrative Agent shall have received a favorable written opinion (addressed to the
Administrative Agent and the Incremental Lenders and dated as of the Incremental Effective Date) of Ropes & Gray LLP, special counsel for the Borrower, in form and substance reasonably satisfactory to the Administrative Agent and its
counsel. The Borrower hereby requests such counsel to deliver such opinions. 
 (c) The Administrative Agent shall have received such
documents and certificates as the Administrative Agent or its counsel may reasonably request relating to the organization, existence and good standing of each Loan Party, the authorization of the Amendment Transactions and any other legal matters
relating to the Loan Parties or the Loan Documents, all in form and substance reasonably satisfactory to the Administrative Agent and its counsel. 
 (d) On the Incremental Effective Date, (i) the conditions set forth in paragraphs (a) and (b) of Section 4.02 of the Credit Agreement shall be satisfied, (ii) immediately prior to and after giving effect to this
Amendment and the making of the Tranche C Term Loans, on a Pro Forma Basis, as of the last day of the most recently ended fiscal quarter of the Borrower for which financial statements have been delivered pursuant to Section 5.01 of the Credit
Agreement, the Borrower shall be in compliance with the covenants contained in Sections 6.12, 6.13 and 6.14 of the Credit Agreement and (iii) the Administrative Agent shall have received a certificate of a Financial Officer of the Borrower,
dated as of the Incremental Effective Date, confirming compliance with the conditions set forth in clauses (i) and (ii) of this paragraph (d). 
 (e) The Administrative Agent shall have received all fees and other amounts due and payable on or prior to the Incremental Effective Date, including, to the extent invoiced, reimbursement or payment of all
out-of-pocket expenses (including reasonable fees, charges and disbursements of counsel) required to be reimbursed by any Loan Party hereunder or under any other Loan Document. 
 (f) The Collateral Agent shall have received amendments to each Mortgage securing the Obligations of the Borrower providing that the Tranche B Term
Loans, Tranche C Term Loans and Revolving Loans shall be secured by a Lien on the Mortgaged Property that is the subject of such Mortgage, signed on behalf of the record owner of such Mortgaged Property. 
 (g) A Reaffirmation Agreement substantially in the form of Exhibit A hereto (the “Reaffirmation Agreement”) shall have been executed and
delivered by each party thereto. 
 Notwithstanding the foregoing, the obligations of the Incremental Lenders to make Tranche C Term Loans
shall not become effective unless each of the foregoing conditions is satisfied at or prior to 5:00 p.m., New York City time, on July 14, 2006 (and, in the event such conditions are not so satisfied, this Amendment shall terminate at such
time). 
 SECTION 19. Representations and Warranties. The Borrower represents and warrants to the Administrative Agent and to each of
the Lenders that: 
 (a) This Amendment has been duly authorized, executed and delivered by the Borrower and constitutes a legal, valid and
binding obligation of the Borrower, enforceable 
  

 8 

 against the Borrower in accordance with its terms, subject to applicable bankruptcy, insolvency, reorganization,
moratorium or other laws affecting creditors’ rights generally and subject to general principles of equity, regardless of whether considered in a proceeding in equity or at law. 
 (b) The performance by any Loan Party of the Amendment Transactions, and compliance by such Loan Party with the terms and provisions of the Reaffirmation
Agreement (and, in the case of the Borrower, this Amendment), (i) do not require any consent or approval of, registration or filing with, or any other action by, any Governmental Authority, except such as have been obtained or made and are in
full force and effect and except filings necessary to perfect Liens created under the Loan Documents, (ii) will not violate any Requirement of Law applicable to Holdings, the Borrower or any of the Subsidiaries, as applicable, (iii) will
not violate or result in a default under any indenture, Management Services Agreement or other material agreement or instrument binding upon Holdings, the Borrower or any of the Subsidiaries or its assets, or give rise to a right thereunder to
require any payment to be made by Holdings, the Borrower or any of the Subsidiaries or give rise to a right of, or result in, termination, cancelation or acceleration of any material obligation thereunder, (iv) will not result in a Limitation
on any right, qualification, approval, permit, accreditation, authorization, Reimbursement Approval, license or franchise or authorization granted by any Governmental Authority, Third Party Payor or other Person applicable to the business,
operations or assets of the Borrower or any of the Subsidiaries or adversely affect the ability of the Borrower or any of the Subsidiaries to participate in any Third Party Payor Arrangement except for Limitations, individually or in the aggregate,
that are not material to the business of the Borrower and the Subsidiaries, taken as a whole, and (v) will not result in the creation or imposition of any Lien on any asset of Holdings, the Borrower or any of the Subsidiaries, except Liens
created under the Loan Documents. 
 (c) The representations and warranties of each Loan Party set forth in the Loan Documents are true and
correct in all material respects (except to the extent any such representation or warranty is qualified by “materially,” “Material Adverse Effect” or a similar term, in which case such representation and warranty shall be true
and correct in all respects) on and as of the Incremental Effective Date with the same effect as though made on and as of such date, except to the extent such representations and warranties expressly relate to an earlier date (in which case such
representations and warranties were true and correct (or true and correct in all material respects, as the case may be) as of such earlier date). 
 (d) Immediately after giving effect to this Amendment, no Default shall have occurred and be continuing. 
 SECTION 20.
Conditions to Effectiveness; Amendments. (a) Section 5 of this Amendment shall become effective as of the date first above written when (i) the Administrative Agent shall have received (A) in the case of Holdings and the
Borrower, counterparts of this Amendment bearing the signatures of Holdings and the Borrower and (B) in the case of the Lenders, counterparts of this Amendment that, when taken together, bear the signatures of Lenders having Revolving Exposures
and unused Revolving Commitments representing more than 50% of the aggregate Revolving Exposures and unused Revolving Commitments and (ii) all fees and, to the extent invoiced prior to the date hereof, expenses required to be paid or reimbursed
by the Borrower under or in connection with this Amendment or the Credit Agreement shall have been paid or reimbursed, as applicable. 
  

 9 

 (b) Sections 12(b) and 13 of this Amendment shall become effective as of the date first above written
when (i) the Administrative Agent shall have received (A) in the case of Holdings and the Borrower, counterparts of this Amendment bearing the signatures of Holdings and the Borrower and (B) in the case of the Lenders, counterparts of
this Amendment that, when taken together, bear the signatures of the Required Lenders and (ii) all fees and, to the extent invoiced prior to the date hereof, expenses required to be paid or reimbursed by the Borrower under or in connection with
this Amendment or the Credit Agreement shall have been paid or reimbursed, as applicable. 
 (c) This Amendment may not be amended nor may
any provision hereof be waived except pursuant to a writing signed by Holdings, the Borrower, the Administrative Agent and the requisite Lenders under Section 9.02 of the Credit Agreement (after giving effect to this Amendment). 
 SECTION 21. Credit Agreement. Except as expressly set forth herein, this Amendment shall not by implication or otherwise limit, impair, constitute
a waiver of, or otherwise affect the rights and remedies of the Lenders, the Agents, the Issuing Bank, Holdings, the Borrower or any other Loan Party under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in any
way affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect. Nothing
herein shall be deemed to entitle Holdings or the Borrower to any future consent to, or waiver, amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any
other Loan Document in similar or different circumstances. After the Incremental Effective Date, any reference to the Credit Agreement shall mean the Credit Agreement as modified hereby, provided that any reference in the Credit Agreement to the
date of the Credit Agreement, as modified hereby, shall in all instances remain as of August 20, 2004, and references in the Credit Agreement to “the date hereof” and “the date of this Agreement,” and phrases of similar
import, shall in all instances be and continue to refer to August 20, 2004, and not the date of this Amendment. This Amendment constitutes an “Incremental Facility Amendment”, the Incremental Lenders constitute “Lenders” and
the Reaffirmation Agreement constitutes “Loan Document”, in each case for all purposes of the Credit Agreement and the other Loan Documents. The Administrative Agent and the Borrower acknowledge and agree that the Incremental Lenders are
satisfactory to them. 
 SECTION 22. Applicable Law; Waiver of Jury Trial. (A) THIS AMENDMENT SHALL BE CONSTRUED IN ACCORDANCE
WITH AND GOVERNED BY THE LAW OF THE STATE OF NEW YORK. 
 (B) EACH PARTY HERETO AGREES AS SET FORTH IN SECTION 9.10 OF THE CREDIT
AGREEMENT AS IF SUCH SECTION WERE SET FORTH IN FULL HEREIN. 
  

 10 

 SECTION 23. Counterparts. This Amendment may be executed in counterparts (and by different parties
hereto on different counterparts), each of which shall constitute an original, but all of which when taken together shall constitute a single contract. Delivery of an executed counterpart of a signature page of this Amendment by telecopy or other
electronic transmission shall be as effective as delivery of a manually executed counterpart of this Amendment. 
 SECTION 24.
Expenses. The Borrower agrees to reimburse the Administrative Agent, the Syndication Agent and the Documentation Agent for their reasonable out-of-pocket expenses in connection with this Amendment, including the reasonable fees, charges and
disbursements of Cravath, Swaine & Moore LLP, counsel for the Administrative Agent. 
 SECTION 25. Headings. The Section
headings used herein are for convenience of reference only, are not part of this Amendment and are not to affect the construction of, or to be taken into consideration in interpreting, this Amendment. 
 SECTION 26. Severability. Any provision of this Amendment held to be invalid, illegal or unenforceable in any jurisdiction shall, as to such
jurisdiction, be ineffective to the extent of such invalidity, illegality or unenforceability without affecting the validity, legality and enforceability of the remaining provisions hereof; and the invalidity of a particular provision in a
particular jurisdiction shall not invalidate such provision in any other jurisdiction. The parties shall endeavor in good-faith negotiations to replace the invalid, illegal or unenforceable provisions with valid provisions, the economic effect of
which comes as close as possible to that of the invalid, illegal or unenforceable provisions. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

  

 11 

 EXHIBIT A 
 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed by their respective authorized officers as of the day and year first written above. 
  

			
	US ONCOLOGY HOLDINGS, INC.,
		
	by	 	  

	Name:	 	
	Title:	 	

			
	US ONCOLOGY, INC.,
		
	by	 	  

	Name:	 	
	Title:	 	

  

 13 

 [LENDERS SIGNATURES FOLLOW] 
  

 14Second Amendment to Employment Agreement

 EXHIBIT 10.1 
 SECOND AMENDMENT TO 
 EMPLOYMENT AGREEMENT 
 THIS SECOND AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is effective as of July 13, 2006, by and between PETCO Animal Supplies, Inc., a Delaware
corporation (“Parent”), PETCO Animal Supplies Stores, Inc., a Delaware corporation (the “Operating Company”) and Brian K. Devine (“Executive”). 
 RECITALS 
  

	 	A.	Parent, the Operating Company and Executive are parties to that certain Amended and Restated Employment Agreement effective as of October 2, 2000, as amended by that certain
First Amendment to Employment Agreement effective as of June 27, 2005 (as amended, the “Employment Agreement”). 

  

	 	B.	The parties desire to amend the Employment Agreement as set forth below with respect to the definition of “Change of Control” as used in the Employment Agreement.

  

	 	C.	Capitalized terms used but not otherwise defined herein shall have the meaning ascribed to them in the Employment Agreement. All Section reference in this Amendment are to Sections
of the Restated Agreement. 

 AGREEMENT 
 In consideration of the mutual covenants set forth in this Agreement and other good and valuable consideration, the sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 
  

	1.	Section 5(q). Section 5(q) of the Employment Agreement is hereby amended to strike the following parenthetical: “(other than B.D. Recapitalization Holdings
LLC, its members and its co-investors (“BUYER”) or their affiliates or a group in which Buyer or its affiliates are the controlling participants).” 

  

	2.	Miscellaneous. This Amendment shall be and is hereby incorporated in and forms a part of the Employment Agreement. All other terms and provisions of the Employment Agreement
shall remain unchanged except as specifically modified herein. The Employment Agreement, as amended by this Amendment, is hereby ratified and confirmed. 

  

 1 

 IN WITNESS HEREOF, the parties have executed this Amendment as of the date set
forth above. 
  

			
	 PARENT:

	
	 PETCO ANIMAL SUPPLIES, INC.

		
	By:	 	 /s/ Rodney Carter

		 	 Rodney Carter

	 Its:
	 	 Senior Vice President and
 Chief Financial Officer

	
	 OPERATING COMPANY:

	
	 PETCO ANIMAL SUPPLIES STORES, INC.

		
	By:	 	 /s/ Rodney Carter

		 	 Rodney Carter

	 Its:
	 	 Senior Vice President and
 Chief Financial Officer

			
	
	 EXECUTIVE:

	
	 /s/ Brian K. Devine

	 Printed Name:
	 	 Brian K. Devine

  

 2

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