Document:

exv10w24

EXHIBIT 10.24

SUBLEASE AGREEMENT

     This SUBLEASE AGREEMENT (“Sublease”) is made as of the 18th day of June, 2009
(“Effective Date”), by and between PHENOMIX CORPORATION, a Delaware corporation (the “Sublandlord”)
and ANADYS PHARMACEUTICALS, INC., a Delaware corporation (the “Subtenant”) with regard to the
following facts.

R E C I T A L S:

     A. Sublandlord is the tenant under that certain Lease Agreement dated as of July 31, 2003 (the
“Master Lease”), with VPI Oberlin I, L.P., a California limited partnership (the “Landlord”) (a
copy of which Master Lease is attached hereto as Exhibit A and by this reference made a part
hereof, subject to the exclusions in Section 7 below and elsewhere in this Sublease) concerning
approximately 16,603 rentable square feet of space (the “Premises”) located in Suite 200 of the
building located at 5871 Oberlin Drive, San Diego, California 92121 (the “Building”).

     B. Subtenant desires to sublease from Sublandlord a portion of the Premises consisting of
approximately 13,893 rentable square feet of space (which portion shall be hereafter referred to as
the “Subleased Premises”) more particularly set forth on Exhibit B, attached hereto, and
Sublandlord has agreed to sublease the Subleased Premises to Subtenant upon the terms, covenants
and conditions herein set forth.

     C. All capitalized terms used herein and not otherwise defined herein shall have the meanings
ascribed to those terms in the Master Lease.

A G R E E M E N T:

     In consideration of the mutual covenants contained herein, the sufficiency of which is hereby
acknowledged, the parties hereto agree as follows:

     1. Sublease. Sublandlord hereby subleases and demises to Subtenant and Subtenant
hereby hires and takes from Sublandlord the Subleased Premises. For the avoidance of doubt, the
Subleased Premises do not include any portion of the vivarium within the Premises and Subtenant
shall have no responsibility or liability whatsoever with respect to such vivarium, and any
references in the Master Lease to the vivarium are not applicable to this Sublease. Sublandlord
may elect to sublet the vivarium separately, in which case, Sublandlord will be responsible for
securing the vivarium and all access to such vivarium separate from the Subleased Premises and in a
manner so as to avoid interference with Subtenant’s use and occupancy of the Subleased Premises.

     2. Term. The term of this Sublease shall commence on the date Sublandlord delivers
the Subleased Premises to Subtenant; provided such date shall occur no later than ten (10) business
days after Landlord provides its consent to this Sublease or July 15, 2009 (provided Landlord has
provided its consent prior to such date), whichever is sooner (“Commencement Date”) and shall end,
unless sooner terminated as provided in the Master Lease on January 31, 2011 (“Expiration Date”).
Sublandlord will use good faith efforts and reasonable diligence to

 

 

cause Landlord to provide its consent to this Sublease as soon as possible after the date of
full execution of this Sublease. In the event such consent is not obtained on or before July 15,
2009, Subtenant shall have the option, by written notice to Sublandlord, to terminate this
Sublease.

     3. Rent. From and after the Commencement Date, Subtenant shall pay base rent during
the term of this Sublease in the amount of Two and 15/100 Dollars ($2.15) per rentable square foot
of the Subleased Premises per month, payable in advance on the first day of each month in equal
monthly installments of Twenty-Nine Thousand Eight Hundred Sixty-Nine and 95/100 Dollars
($29,869.95). Additionally, Subtenant shall pay eighty-three and sixty-seven one-hundredths
percent (83.67%) of all Operating Expenses charged to Sublandlord under the terms of the Master
Lease and Subtenant shall be responsible for all separately metered utilities, trash and janitorial
services provided to the Subleased Premises. In the event Sublandlord finds a third party
subtenant for the vivarium, Sublandlord and Subtenant will mutually agree to an equitable method
for pro rating utilities and services between the Subleased Premises and the vivarium. In the
event that the term of this Sublease shall begin or end on a date which is not the first day of a
month, base rent shall be prorated as of such date. On the Commencement Date, Subtenant shall
deliver to Sublandlord the first month’s rent, plus the amount of $29,869.95 as a Security Deposit
to be held by Sublandlord pursuant to the terms of Section 18 of the Master Lease.

     4. Use. Subtenant covenants and agrees to use the Premises in accordance with the
provisions of the Master Lease and for no other purpose and otherwise in accordance with the terms
and conditions of the Master Lease and this Sublease. Subtenant may require the use of areas
outside the Subleased Premises for equipment used in connection with its business activities, and
Subtenant will obtain Sublandlord’s consent prior to such use and, if such consent is provided by
Sublandlord, Sublandlord agrees to use commercially reasonable efforts to obtain Landlord’s consent
to such use.

     5. Master Lease. As applied to this Sublease, the words “Landlord” and “Tenant” as
used in the Master Lease shall be deemed to refer to Sublandlord and Subtenant hereunder,
respectively. Subtenant and this Sublease shall be subject in all respects to the terms of, and
the rights of the Landlord under, the Master Lease. Except as otherwise expressly provided in
Section 7 hereof, the covenants, agreements, terms, provisions and conditions of the Master Lease
insofar as they relate to the Subleased Premises and insofar as they are not inconsistent with the
terms of this Sublease are made a part of and incorporated into this Sublease as if recited herein
in full, and the rights and obligations of the Landlord and the Tenant under the Master Lease shall
be deemed the rights and obligations of Sublandlord and Subtenant respectively hereunder and shall
be binding upon and inure to the benefit of Sublandlord and Subtenant respectively. As between the
parties hereto only, in the event of a conflict between the terms of the Master Lease and the terms
of this Sublease, the terms of this Sublease shall control.

     6. Landlord’s Performance Under Master Lease.

          6.1 Subtenant recognizes that Sublandlord is not in a position to render any of the services
or to perform any of the obligations required of the Landlord by the terms of the Master Lease.
Therefore, notwithstanding anything to the contrary contained in this Sublease, Subtenant agrees
that performance by Sublandlord of its obligations hereunder to the extent such

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obligations are dependent on performance by Landlord, are conditional upon due performance by
the Landlord of its corresponding obligations under the Master Lease and Sublandlord shall not be
liable to Subtenant for any default of the Landlord under the Master Lease. Subtenant shall not
have any claim against Sublandlord by reason of the Landlord’s failure or refusal to comply with
any of the provisions of the Master Lease unless such failure or refusal is a result of
Sublandlord’s act or failure to act. Sublandlord hereby agrees to use commercially reasonable
efforts to enforce the terms of the Master Lease against Landlord. This Sublease shall remain in
full force and effect notwithstanding the Landlord’s failure or refusal to comply with any such
provisions of the Master Lease and Subtenant shall pay the base rent and additional rent and all
other charges provided for herein without any abatement, deduction or setoff whatsoever. Subtenant
covenants and warrants that it fully understands and agrees to be subject to and bound by all of
the covenants, agreements, terms, provisions and conditions of the Master Lease, except as modified
herein. Furthermore, Subtenant and Sublandlord further covenant not to take any action or do or
perform any act or fail to perform any act which would result in the failure or breach of any of
the covenants, agreements, terms, provisions or conditions of the Master Lease on the part of the
Tenant thereunder.

          6.2 Whenever the consent of Landlord shall be required by, or Landlord shall fail to perform
its obligations under, the Master Lease, Sublandlord agrees to use its best efforts to obtain, at
Subtenant’s sole cost and expense, such consent and/or performance on behalf of Subtenant.
Notwithstanding the foregoing, Sublandlord and Subtenant will each pay one half of the amount
charged by Landlord for its consent to this Sublease.

          6.3 Sublandlord represents and warrants to Subtenant that (a) the Master Lease is in full
force and effect and the attached Exhibit A is a true, correct and complete copy of the Master
Lease; (b) all obligations of both Landlord and Sublandlord thereunder have been satisfied; (c)
Sublandlord has neither given nor received a notice of default pursuant to the Master Lease and (d)
the Premises as of the Commencement Date are and have been in compliance with Sections 5.2 and 24
of the Master Lease.

          6.4 Sublandlord covenants as follows: (i) not to voluntarily terminate the Master Lease,
(ii) not to modify the Master Lease so as to adversely affect Subtenant’s rights hereunder, and
(iii) to take all actions reasonably necessary to preserve the Master Lease.

     7. Variations from Master Lease. The following covenants, agreements, terms,
provisions and conditions of the Master Lease are hereby modified or not incorporated herein:

          7.1 Notwithstanding anything to the contrary set forth in Sections 3, 7 and 18 of the Master
Lease, the term of this Sublease and base rent payable under this Sublease and the amount of the
Security Deposit required of Subtenant shall be as set forth in Sections 2 and 3 above. In
addition, the last three (3) sentences of Section 18 (security interest in trade fixtures) shall
not apply to Subtenant or this Sublease.

          7.2 The parties hereto represent and warrant to each other that neither party dealt with any
broker other than Irving Hughes and Jones Lang LaSalle Americas, Inc. (“Broker”) in connection with
the consummation of this Sublease and each party agrees to indemnify, hold and save the other party
harmless from and against any and all claims for

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brokerage commissions arising out of either of their acts in connection with this Sublease,
other than the fees payable to Broker, which such fees shall be paid by Sublandlord. In the event
Sublandlord fails to pay the Subtenant’s Broker its leasing commission in an amount equal to four
percent (4%) of the base rent, Subtenant may offset its rent by an amount equal to the unpaid
commission due to the Subtenant’s Broker, plus interest at the rate of 10% of the amount due (or
the highest rate permitted by law, whichever is less); provided, however, that in the event
Subtenant offsets its rental obligation by an amount equal to the unpaid commission due to the
Subtenant’s Broker, Subtenant hereby agrees and hereby does indemnify, hold and save Sublandlord
harmless from and against any and all claims for brokerage commissions from the Subtenant’s Broker.
The provisions of this Section 7.2 shall survive the expiration or earlier termination of this
Sublease.

          7.3 Notwithstanding anything contained in the Master Lease to the contrary, as between
Sublandlord and Subtenant only, all insurance proceeds or condemnation awards received by
Sublandlord under the Master Lease shall be deemed to be the property of Sublandlord, and any
proceeds received by Subtenant will be deemed to be the property of Subtenant.

          7.4 Any notice which may or shall be given by either party hereunder shall be either delivered
personally or sent by certified mail, return receipt requested, addressed to Anadys
Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, Attn: Controller, Finance
(if to Subtenant prior to the Commencement Date), or to Anadys Pharmaceuticals, Inc., 5871 Oberlin
Drive, Suite 200, San Diego, California 92121, Attn: Controller, Finance (if to Subtenant after the
Commencement Date), or c/o Phenomix Corporation, 5930 Cornerstone Court West, Suite 230, San Diego,
California 92121, Attn: Corporate Counsel (if to the Sublandlord), or to such other address as may
have been designated in a notice given in accordance with the provisions of this Section 7.4. Upon
receipt of any notice from Landlord relating to the Premises, Sublandlord shall promptly deliver a
copy of such notice to Subtenant in accordance with the terms and conditions of this Section 7.4.

          7.5 All amounts payable hereunder by Subtenant shall be payable directly to Sublandlord and
sent to c/o Phenomix Corporation, 5930 Cornerstone Court West, Suite 230, San Diego, California
92121, Attn: Accounts Payable. The foregoing is subject to the assignment of rents set forth in
Section 21 of the Master Lease.

          7.6 The provisions of Sections 2.1, 2.2, 2.3, 2.5, 2.6, 2.8 (as to payments only), 2.12, 2.13,
2.14, 2.15, 2.16, 4, 5.6, 30, 36.1, the last two sentences of Section 14, the last three sentences
of Section 18, the first sentence of Section 24 (provided that all references in Section 24 to
Landlord shall mean and refer to the Landlord and not Sublandlord and that the requirement to
remediate, if necessary, will be determined by Landlord and not Sublandlord, but that all notices
will be delivered to both Landlord and Sublandlord), and Exhibits A-2, D, E and F of the Master
Lease shall not apply to this Sublease.

          7.7 Sublandlord shall deliver the Subleased Premises to Subtenant in its current “as is”
condition, except that all HVAC, electrical, life safety, security system, generator and plumbing
systems shall be in good working order on the Commencement Date hereof.

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          7.8 Subtenant shall be permitted to use all existing FF&E in the Subleased Premises at no cost
during the term of this Sublease. The title to the FF&E in the Subleased Premises shall remain
with Sublandlord and a list of such FF&E is attached hereto as Exhibit C. Subtenant shall not be
required to remove any alterations or improvements located in the Subleased Premises upon the
expiration of the term hereof or to perform any other restoration requirements set forth in the
Master Lease (including Section 14 of the Master Lease); provided however that Subtenant will
surrender the Subleased Premises in as good condition and repair as received, reasonable wear and
tear and casualty damage excepted (subject to Section 10 below) and shall remove its personal
property from the Subleased Premises prior to the Expiration Date.

          7.9 Sublandlord agrees to indemnify, defend, protect and hold Subtenant harmless from and
against any and all claims, actions, administrative proceedings, judgments, damages, punitive
damages, penalties, fines, costs, liabilities, losses, including reasonable attorneys’ fees and
expenses regarding the presence and/or remediation of any Hazardous Substances at, on or about the
Subleased Premises existing prior to the term of this Sublease other than any Hazardous Substances
brought onto the Subleased Premises by Subtenant and/or its assignees, agents, employees,
contractors or licensees. The provisions of this Section 7.9 shall survive the expiration or
earlier termination of the Master Lease and/or this Sublease.

          7.10 Sections 11.1, 11.2 and 11.3 of the Master Lease shall be applicable to Subtenant’s
insurance obligations pursuant to this Sublease with the following changes:

               (a) Subtenant will not be required to obtain business interruption insurance and Subtenant’s
property insurance will not cover any improvements or alterations within the Subleased Premises
(which will be covered by Sublandlord’s insurance);

               (b) The liability policy carried by Subtenant is a general liability and not public liability
policy;

               (c) Subtenant’s products and pollution liability insurance may be written on a claims made
basis, but all other insurance will be written on an occurrence basis; and

               (d) The deductible amount of Tenant’s insurance may not exceed $25,000.

          7.11 Subtenant shall have the right to install the phone system which is currently in the
Subleased Premises but not installed. Subtenant shall pay for any installation and maintenance of
such phone system. At no cost to Subtenant, Sublandlord shall leave the existing network cabling,
patch panel, and rack, with all wires labeled, for Subtenant’s use. The title of such phone system
shall remain with Sublandlord.

          7.12 Sublandlord agrees to allow Subtenant access to the roof top for the maintenance of
equipment, subject to receipt of approval from the Landlord.

     8. Indemnity. Except to the extent any such claims, losses and damages are caused by,
or are the result of, the negligence of Sublandlord and/or its assignees, agents, employees,
contractors or licensees, Subtenant hereby agrees to indemnify and hold Sublandlord harmless

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from and against any and all claims, losses and damages, including, without limitation,
reasonable attorneys’ fees and disbursements, which may at any time be asserted against Sublandlord
by (a) the Landlord for failure of Subtenant to perform any of the covenants, agreements, terms,
provisions or conditions contained in the Master Lease which by reason of the provisions of this
Sublease Subtenant is obligated to perform, or (b) any person by reason of Subtenant’s use and/or
occupancy of the Subleased Premises. Sublandlord hereby agrees to defend, indemnify and hold
harmless Subtenant from and against any and all claims, actions, liabilities, losses, damages,
costs and expenses (including, without limitation, reasonable attorneys’ fees and disbursements)
arising from Sublandlord’s breach of any provisions of this Sublease. The provisions of this
Section 8 shall survive the expiration or earlier termination of the Master Lease and/or this
Sublease.

     9. Cancellation of Master Lease. In the event of the cancellation or termination of
the Master Lease for any reason whatsoever or of the involuntary surrender of the Master Lease by
operation of law prior to the expiration date of this Sublease, Subtenant agrees to make full and
complete attornment to the Landlord under the Master Lease for the balance of the term of this
Sublease and upon the then executory terms hereof at the option of the Landlord at any time during
Subtenant’s occupancy of the Premises, which attornment shall be evidenced by an agreement in form
and substance reasonably satisfactory to the Landlord and Subtenant. Subtenant agrees to execute
and deliver such an agreement at any time within ten (10) business days after request of the
Landlord, and Subtenant waives the provisions of any law now or hereafter in effect which may give
Subtenant any right of election to terminate this Sublease or to surrender possession of the
Subleased Premises in the event any proceeding is brought by the Landlord under the Master Lease to
terminate the Master Lease.

     10. Hazardous Substances. On or before the Commencement Date, Sublandlord shall
deliver to Subtenant a Phase I Environmental Site Assessment with respect to the Subleased Premises
in accordance with the standards set forth in Exhibit G to the Master Lease; provided, however,
that Sublandlord makes no representation or warranty regarding such report, except that in the
event any contamination is evidenced in such report, such contamination will not be the
responsibility of Subtenant and Sublandlord will indemnify, defend and hold Subtenant harmless from
and against any claims made against Subtenant as a result of such contamination. Within three (3)
business days of the Expiration Date, Subtenant shall deliver to Sublandlord a Phase I
Environmental Site Assessment dated through the Expiration Date in accordance with the standards
set forth in Exhibit G to the Master Lease; provided, however, that Subtenant makes no
representation or warranty regarding such report.

     11. Certificates. Each party hereto shall at any time and from time to time as
requested by the other party upon not less than ten (10) days prior written notice, execute,
acknowledge and deliver to the other party, a statement in writing certifying that this Sublease is
unmodified and in full force and effect (or if there have been modifications that the same is in
full force and effect as modified and stating the modifications, if any), certifying the dates to
which rent and any other charges have been paid and stating whether or not, to the knowledge of the
person signing the certificate, the other party is in default beyond any applicable grace period
provided herein in performance of any of its obligations under this Sublease, and if so, specifying
each such default of which the signer may have knowledge, it being intended that any

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such statement delivered pursuant hereto may be relied upon by others with whom the party
requesting such certificate may be dealing.

     12. Assignment or Subletting. Subject to all of the rights of the Landlord under the
Master Lease and the restrictions contained in the Master Lease, Subtenant shall not be entitled to
assign this Sublease or to sublet all or any portion of the Premises without the prior written
consent of Sublandlord, which consent may be withheld by Sublandlord in its sole discretion.
Notwithstanding the foregoing, Subtenant may enter into a “Permitted Transfer” as defined in the
Master Lease without obtaining Landlord’s or Sublandlord’s consent.

     13. Severability. If any term or provision of this Sublease or the application
thereof to any person or circumstances shall, to any extent, be invalid and unenforceable, the
remainder of this Sublease or the application of such term or provision to persons or circumstances
other than those as to which it is held invalid or unenforceable, shall not be affected thereby and
each term or provision of this Sublease shall be valid and be enforced to the fullest extent
permitted by law.

     14. Entire Agreement; Waiver. This Sublease contains the entire agreement between the
parties hereto and shall be binding upon and inure to the benefit of their respective heirs,
representatives, successors and permitted assigns. Any agreement hereinafter made shall be
ineffective to change, modify, waive, release, discharge, terminate or effect an abandonment
hereof, in whole or in part, unless such agreement is in writing and signed by the parties hereto.

     15. Captions and Definitions. Captions to the Sections in this Sublease are included
for convenience only and are not intended and shall not be deemed to modify or explain any of the
terms of this Sublease.

     16. Further Assurances. The parties hereto agree that each of them, upon the request
of the other party, shall execute and deliver, in recordable form if necessary, such further
documents, instruments or agreements and shall take such further action that may be necessary or
appropriate to effectuate the purposes of this Sublease.

     17. Governing Law. This Sublease shall be governed by and in all respects construed
in accordance with the internal laws of the State of California.

     18. Attorneys’ Fees. If either party commences legal action against the other party
in connection with this Sublease, the prevailing party will be entitled to recover costs of suit
and reasonable attorneys’ fees.

     19. Consent of Landlord. The validity of this Sublease shall be subject to the
Landlord’s prior written consent hereto pursuant to the terms of the Master Lease, and if
Landlord’s consent shall not be obtained and a copy thereof delivered to Subtenant within thirty
(30) days of the date hereof, Subtenant shall have the option to cancel this Sublease by notice to
Sublandlord within forty (40) days from the date hereof.

[Remainder of Page Intentionally Left Blank]

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     IN WITNESS WHEREOF, the parties hereto have caused this Sublease to be executed as of the day
and year first above written.

	 	 	 	 	 	 	 
	     Sublandlord:	 	PHENOMIX CORPORATION,	 	 
	 	 	a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Hans-Peter Guler
 

	 	 
	 

	 	Name:
	 	Hans-Peter Guler, M.D.
	 	 
	 

	 	Title:
	 	Chief Medical Officer	 	 
	 
	 	 	 	 	 	 
	     Subtenant:	 	ANADYS PHARMACEUTICALS, INC.,	 	 
	 	 	a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Stephen T. Worland
 

	 	 
	 

	 	Name:
	 	Stephen T. Worland, Ph.D.
	 	 
	 

	 	Title:
	 	President and Chief Executive Officer	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ James T. Glover
 

	 	 
	 

	 	Name:
	 	James T. Glover
	 	 
	 

	 	Title:
	 	Senior Vice President, Operations and Chief	 	 
	 

	 	 	 	Financial Officer	 	 

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EXHIBIT A

THE MASTER LEASE

LEASE AGREEMENT

     This Lease Agreement (this “Lease”) is entered into as of July 31, 2003, between VPI OBERLIN
I, L.P., a California limited partnership (“Landlord”), and PHENOMIX CORPORATION, a Delaware
corporation (“Tenant”), who agree as follows with respect to the real property located at 5871
Oberlin Drive, San Diego, California, described on the attached Exhibit A-1 (the “Project”) on
which is located a building consisting of approximately 33,728 square feet (the “Building”) as
depicted on the Building Floor Plan attached to this Lease as Exhibit B (the “Building Floor
Plan”):

     1. Agreement to Let. Landlord leases to Tenant, and Tenant leases from Landlord, the
premises defined below, along with the non-exclusive right to use those portions of the Project
owned by Landlord and intended for common use by tenants and invitees of the Project, including the
Building lobby, landscaped areas, common passageways, walkways, hallways, parking areas, and
driveways (the “Common Area”). Except as specifically set forth herein, this Lease confers no
rights, however, to the roof, exterior walls, or utility raceways of the Building, nor with regard
to either the subsurface of the land below the ground level of the Project or with regard to the
air space above the ceiling of the Building, or to parking spaces not assigned to Tenant. Tenant’s
rental obligations and rights to possession do not begin until the Commencement Date as defined
below.

     2. Principal Lease Provisions and Definitions. The following are the “Principal Lease
Provisions” of and definitions applicable to this Lease. Other portions of this Lease explain and
define the Principal Lease Provisions in more detail and should be read in conjunction with this
Article.

          2.1 “Basic Monthly Rent” means the sum of the following, on a fully net basis: (a) the product
of $2.65 multiplied by the number of Rentable Square Feet of the Premises, plus (b) the product of
0.01559 multiplied by the Additional Allowance, if any. Basic Monthly Rent is increased by 3.5% on
the first day of the calendar month that is one year after the Commencement Date, and again on each
anniversary of such date of rent increase.

          2.2 “Broker” means Steve Bollert of Burnham Real Estate. The parties acknowledge and agree
that the Broker is acting as a dual agent, and the parties consent to such dual agency, but neither
broker nor any of its agents may bind Landlord or Tenant or make any representations on behalf of
Landlord or Tenant (and neither Landlord nor Tenant may rely on any representations, warranties, or
commitments made by Broker).

          2.3 “Commencement Date,” as to all portions of the Premises other than the vivarium, means the
earliest of the following: (a) the date on which Phase 1 of Landlord’s Work is Substantially
Completed (as defined below); (b) the date on which Phase 1 of Landlord’s Work would have been
substantially completed if not for Tenant Delay; and (c) the date on which Tenant first conducts
business on the Premises. “Commencement Date,” as to the vivarium, means the earliest of the
following: (a) the date on which construction of

 

 

the vivarium is Substantially Completed (as defined below); (b) the date on which construction of
the vivarium would have been substantially completed if not for Tenant Delay; and (c) the date on
which Tenant first conducts operations in the vivarium. For purposes of this Lease, “Substantially
Completed” means the date on which all of the following have occurred: (i) the City of San Diego
Building Inspector gives its final sign-off on any building inspection record card for the
applicable Phase of Landlord’s Work or a temporary certificate of occupancy is issued for the
applicable Phase of Landlord’s Work, and (ii) the applicable Phase of Landlord’s Work is in a
condition that Tenant can begin operations from the applicable portion of the Premises, subject
only to minor punch-list items. Within 30 days after substantial completion of the applicable Phase
of Landlord’s work, Landlord and Tenant shall: (a) participate in a joint walk through of the
Premises for the purpose of preparing a punch-list of items of required repair or other
deficiencies in construction (and Landlord shall use commercially reasonable efforts to cause the
punch-list items to be corrected as soon as possible); and (b) acknowledge, in a mutually executed
instrument, the Commencement Date as to such phase, Tenant’s acceptance of the Premises including
the applicable Phase of Landlord’s Work, the Expiration Date, the Rentable Square Feet of Premises,
and the Basic Monthly Rent. Notwithstanding anything to the contrary contained in the paragraph, if
the vivarium is not completed in accordance with this Lease within 20 weeks after issuance of the
Vivarium Permit, as defined in Section 2.5 (the “Vivarium Deadline”) for any reason other than
Tenant Delay or force majeure delay, then Basic Monthly Rent will be abated as follows (prorated
for the number of days within the applicable delay period):

	 	 	 	 	 
	Period of Delay after Vivarium Deadline	 	Applicable Monthly Rent Abated	 
	First 30 days
	 	$	7,420	 
	31st – 60th day
	 	$	13,250	 
	61st – 90th day
	 	$	26,500	 
	Any subsequent delay
	 	All Basic Monthly Rent

          2.4 “Expiration Date” means the date that is the seventh anniversary of the last day of the
calendar month in which the Commencement Date occurs.

          2.5 Landlord’sWork. Landlord’s Work is defined and addressed in the attached Exhibit A-2.

          2.6 “Landlord’s Warranty Obligations” means Landlord’s obligations to Tenant to correct any
defects in Landlord’s Work that are specifically identified in writing by Tenant to Landlord during
the first year after the Commencement Date, and to complete Landlord’s Work in compliance with all
Applicable Regulations. Landlord shall to fulfill Landlord’s Warranty Obligations.

          2.7 Notice Addresses for Tenant: At the Premises.

          2.8 Notice and Payment Address for Landlord: VPI Oberlin I, L.P., ATTN: Daniel Ryan, 4350 La
Jolla Village Drive, Suite 960, San Diego, California, 92122; with a copy of notices to: Vanguard
Law Group, LLP, ATTN: Jeffrey A. Schneider, Esq., 8910 University Center Lane, Suite 500, San
Diego, California 92122.

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          2.9 “Operations Plan” means a detailed lists of chemicals (including all codes and
classifications) to be used or located in the Premises or used or transported by Tenant or its
Invitees on the Project. Tenant shall deliver the Operations Plan to Landlord concurrent with the
execution of this Lease and an updated Operations Plan on each anniversary of this Lease. If, at
any time during the Term, Tenant desires to use material amounts of chemicals not identified in the
Operations Plan on a regular basis, Tenant shall provide Landlord with an updated Operations Plan
before integrating the use of the new chemicals into Tenant’s operations.

          2.10 “Permitted Use” means Tenant’s use of the Premises for general office, laboratory, and
support areas for biomedical research and development in accordance with the Operations Plan (as
amended from time to time) and all Applicable Regulations (subject to Section 5.6 below).

          2.11 “Premises” means the portion of the Building depicted on the site plan attached as
Exhibit “C” to this Lease.

          2.12 Rent Holiday: Tenant is not obligated to pay Basic Monthly Rent or Tenant’s Pro Rata
Share of Operating Expenses for the Premises (other than the vivarium) on account of the first 120
days after the Commencement Date of the Premises unless and until Tenant commits a default under
this Lease (that is not cured within the applicable cure period). Similarly, Tenant is not
obligated to pay Basic Monthly Rent or Tenant’s Pro Rata Share of Operating Expenses for the
vivarium space on account of the first 120 days after the Commencement Date for the vivarium as
determined in accordance with Section 2.3 unless and until Tenant commits a default under this
Lease (that is not cured within the applicable cure period).

          2.13 “Rentable Square Feet” of the Building means 33,728 square feet (based on drip line).
Rentable Square Feet of the Premises means the number of square feet of the Premises plus Tenant’s
Pro Rata Share of the number of square feet of Common Area in the Building based on the customary
industrial drip-line” measurement standard, as reasonably determined by the TI Architect. Within 30
days after Landlord’s Work is Substantially Completed, Landlord shall cause the TI Architect to
measure the Premises and the Common Area and to certify the Rentable Square Feet of the Premises.
Landlord and Tenant agree that such figures are deemed accurate and, therefore, not subject to
re-measurement or adjustment by Landlord or Tenant. Landlord and Tenant estimate that the Rentable
Square Feet of the Premises will be approximately 16,603 square feet.

          2.14 “Security Deposit” means cash or letter of credit in an amount equal to four months of
Basic Monthly Rent, as that amount may change from time to time. If, at any time during the Term,
after Landlord’s request, Tenant cannot reasonably establish to Landlord that Tenant’s unencumbered
cash holdings equal or exceed $3.5 million, then Tenant shall increase the Security Deposit to an
amount equal to six months of the then current Basic Monthly Rent.

          2.15 “Tenant Delay” means delay to any portion of Landlord’s Work caused by Tenant or its
agents, such as delays for long lead-time items requested by Tenant, delays resulting from Tenant
or its agents interference with the construction process, delays resulting

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from requests by Tenant to make changes to Landlord’s Work, and delays resulting from Tenant’s
failure to appropriately respond within five business days after Landlord’s written request for
information relating to construction of Landlord’s Work or otherwise within any time period
prescribed in this Lease. Tenant shall cause its authorized representative to attend each weekly
construction meeting relating to Landlord’s Work (and information requested from Tenant in any such
meeting and included in the minutes for the meeting constitutes written request for information
contemplated by the preceding sentence).

          2.16 “Tenant’s Pro Rata Share” means the ratio of Rentable Square Feet of the Premises to the
Rentable Square Feet of the Building. Landlord and Tenant estimate that Tenant’s Pro Rata Share
will be approximately 49.23%.

     3. Term. The term of this Lease (the “Term”) commences on the date of this Lease and
expires on the Expiration Date, subject to earlier termination in accordance with this Lease.

     4. Possession. Tenant is entitled to possession of the Premises on substantial
completion of Landlord’s Work. When taking possession of the Premises, Tenant will be deemed to
have thoroughly inspected the Premises and accepted the Premises in its as-is condition with no
right to require Landlord to perform any work to the Premises or the Project (except any minor
items set forth on a “punch-list” of excepted items with respect to Landlord’s Work delivered to
and accepted by Landlord within 30 days after Tenant takes possession of the Premises), subject to
Landlord’s Warranty Obligations set forth above. Except as Landlord’s Warranty Obligations, Tenant
waives all warranties, whether express or implied (including any warranties of merchantability or
fitness for a particular purpose), with respect to the Premises.

     5. Use of Premises.

          5.1 Permitted Use. Tenant may use the Premises for the Permitted Use and for no other
use. Any change in the Permitted Use requires Landlord’s prior written consent, which consent may
be granted or withheld in Landlord’s reasonable discretion.

          5.2 Compliance with Laws. Subject to Landlord’s Warranty Obligations, Tenant shall
comply with all laws concerning the Premises or Tenant’s use of the Premises, including the
obligation at Tenant’s sole cost to alter, maintain, and restore the Premises in compliance with
all applicable laws, even if the laws are enacted after the date of this Lease, even if compliance
entails costs to Tenant of a substantial nature, and even if compliance requires structural
alterations. Such obligation to comply with laws includes compliance with the Americans With
Disabilities Act of 1990 (42 U.S.C. 12181 et seq.) (the “ADA”). If because of changes in the law,
including changes to the ADA, modifications to the Common Area are required, Landlord shall cause
the Common Area to conform with such new laws or regulations (the costs of which are to be paid by
Landlord and amortized in Operating Expenses to the extent described in Section 8.1 below);
provided, however, if Tenant’s particular use of the Premises results in the need for modifications
or alterations to the Project (beyond Landlord’s Work), then Tenant shall promptly cause the
completion of such modifications and alterations, at Tenant’s sole cost, in accordance with Article
13 below.

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          5.3 General Covenants and Limitations on Use. Tenant may not do, bring, or keep
anything in or about the Premises that will cause a cancellation of any insurance covering the
premises or the Project, provided Landlord has notified Tenant and given Tenant a reasonable
opportunity to bring its use into compliance to avoid cancellation of insurance or to procure
alternative insurance reasonably acceptable to Landlord. If the rate of any insurance carried by
Landlord is increased as a result of Tenant’s particular use of the Premises, Tenant shall pay to
Landlord, within 10 days after Landlord delivers to Tenant a notice of such increase, the amount of
such increase. Furthermore, Tenant shall take all reasonable precautions to prevent any noxious
activity from being carried on, in, on, or around the Premises, and to prevent anything from being
done or kept in, on, or around the Premises that may be or become a public nuisance or that may
cause disturbance, or annoyance to others in the Project, or on adjacent or nearby property. For
example, Tenant shall take all reasonable measures to eliminate or minimize any noxious odors
emanating from the Premises; provided, however, if in Landlord’s reasonable opinion, the vivarium
is producing offensive or noxious odors, Tenant shall install and maintain carbon filters (at its
sole costs), but the filter-housing will be provided by Landlord at its costs. Without limiting the
generality of the foregoing, all unsightly equipment, objects, and conditions shall be kept
enclosed within the Premises; no refuse, scraps, debris, garbage, trash, bulk materials, or waste
shall be kept, stored, or allowed to accumulate except as may be properly enclosed within the
Premises or in any trash areas in the Project designated by Landlord (provided that Landlord has
provided adequate trash areas for the Project); and all pipes, wires, poles, antennas, and other
facilities for utilities or the transmission or reception of audio or visual signals shall be kept
and maintained enclosed within the Premises. Tenant may not keep or permit to be kept any
motorcycle, or other vehicle, nor any animal (excluding certified service dogs), bird, reptile, or
other exotic creature in, on or around the Premises, except for any research rodents (i.e., mice,
hamsters, gerbils, and rats) residing in enclosed cages within the vivarium area in accordance with
all Applicable Regulations subject to Section 5.6 below. Neither Tenant nor Tenant’s Invitees may
do anything that will cause damage or waste to the Project. No machinery, apparatus, or other
appliance may be used or operated in or on the Premises that will in any manner injure, vibrate, or
shake all or any part of the Project. Tenant shall ensure that none of its employees, agents or
Tenant’s Invitees prop open any doors or window or circumvent any security for the Project.

          5.4 Use of Common Area. Tenant shall, and shall cause its guests, invitees, customers,
service-providers, and licensees (collectively, “Tenant’s Invitees”) to, comply with all rules and
regulations regarding the Common Area as Landlord may from time to rime reasonably adopt. Landlord
need not enforce the rules and regulations against other tenants of the Project, but if Landlord
enforces such rules, it must do so in a non-discriminatory manner. Tenant may not store any
property in the Common Area, whether temporarily or permanently (except that Tenant may locate its
generator on the generator pad to be located in the Common Area and designated by Landlord for
Tenant’s use and, subject to reasonable approval of Landlord and the other tenant(s) of the
Project, establish a reception desk in the lobby area of the Building). Any property stored in the
Common Area in violation of the foregoing may be removed by Landlord and disposed of, and the cost
of such removal, storage, and disposal is payable by Tenant on demand. Additionally, in no event
may Tenant use any portion of the Common Area for loading, unloading, or parking, except in those
areas specifically designated by Landlord for such purposes, nor for any sidewalk sale,
advertising, or other commercial purpose. Tenant acknowledges the unique nature of the Common Area
lobby. Although Tenant’s use of such

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special Common Area is subject to Landlord’s rules and regulations, Tenant recognizes that it may
suffer conflicts with other tenant(s) within the Project. The intent of parties is that the lobby
will allow for each tenant of the Project to locate its own employee for reception purposes or to
make its own arrangements (of which Landlord will have no involvement) with the other tenant(s) of
the Project for shared reception personnel. Tenant acknowledges that it specifically negotiated for
the opportunity to have such special Common Area for its own economic purposes; and Tenant assumes
all liabilities and obligations and claims arising out of the shared use of the Common Area (and
Tenant waives any rights or claims or actions it may have against Landlord on account of any
losses, liabilities, or damages suffered by Tenant in connection with the shared use of the Common
Area) other than as caused by Landlord’s gross negligence or willful conduct. The preceding
sentence is not to be interpreted as creating any indemnity obligation by Tenant.

          5.5 Parking. Neither Tenant nor Tenant’s invitees may use the parking area within the
Project (the “Parking Area”) except for Tenant’s Pro Rata Share of parking spaces designated in the
Parking Area for parking and the driveways leading to them. Tenant shall comply with Landlord’s
request, from time to time, to remove all vehicles from the Parking Area for purposes of
maintenance and repair provided such maintenance and repair is conducted outside of normal business
hours or Landlord provides alternative reasonable arrangements for Tenant’s employees to park. No
personal property of any type may be stored or located in the Parking Area, and parking spaces may
only be occupied by appropriately sized vehicles.

          5.6 Vivarium Use. The parties acknowledge that restrictions in the covenants,
conditions, and restrictions governing the Project (the “CC&R’s”) may be interpreted to prohibit
the use of the vivarium contemplated by this Lease. If Landlord or Tenant receive a notice from the
association responsible for enforcing the CC&R’s or any “Owner” as defined in the CC&R’s
(collectively referred to as the “Association”) requesting termination of the use of the vivarium,
it shall notify the other, and Tenant and Landlord shall work together (at Landlord’s cost and
direction) to obtain the Association’s consent (whether voluntary or involuntary) to the continued
use of the vivarium. Landlord shall reimburse Tenant for all out-of-pocket costs incurred in
connection with such defense and appeal (including attorneys fees and costs) and Landlord shall
indemnify and defend Tenant from any claims and liabilities arising out of the CC&R’s or the
Association on account of the use of the vivarium in accordance with this Lease. If, after
exhausting all appeals and remedies, Landlord and Tenant mutually and reasonably determine that
legal termination of Tenant’s use of the vivarium is imminent on account of violation of the
CC&R’s, then: (a) Tenant shall relocate its vivarium use to another facility; (b) Basic Monthly
Rent will be reduced by the product of the Basic Monthly Rent multiplied by the fraction, the
numerator of which is the Rentable Square Feet of the vivarium area and the denominator of which is
the Rentable Square Feet of the Premises; and (c) Landlord shall reimburse Tenant for the following
costs reasonably incurred by Tenant: (i) the costs of relocating the animals (and, if necessary,
any equipment) from the vivarium within the Premises to another local vivarium facility; (ii) the
positive difference, if any, between the per-square-foot cost of the new vivarium facility (to the
extent of its comparable facilities) minus the per-square-foot cost of the rent abatement described
above, multiplied by the number of square feet of the vivarium depicted on the Floor Plan; and
(iii) any actual losses incurred by Tenant from any existing contracts between Tenant and its
clients resulting directly from the delays caused by the vivarium relocation.

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     6. Signs. Tenant is entitled to Tenant’s Pro Rata Share of signage rights on the
Premises in accordance with all applicable laws, regulations, and covenants, conditions and
restrictions governing the Premises. Such signage rights include the right to install a monument
sign and lobby directory subject to Landlord’s prior written consent (which may not unreasonably be
withheld). Nevertheless, Tenant may not place, construct, or maintain any sign, advertisement,
awning, banner, or other exterior decoration in the Premises which is visible from the exterior of
the Premises (including inside the windows of the Premises), without Landlord’s prior written
consent, which consent may not be unreasonably withheld. Tenant shall, at Tenant’s sole cost, make
any changes to any of Tenant’s signage on the Project as required by any new or revised Applicable
Regulation. Tenant shall install, maintain, repair, and replace all of Tenant’s signs at its sole
cost and in first class condition.

     7. Monthly Rent. Tenant shall pay to Landlord as minimum monthly rent, without
deduction, setoff, prior notice, or demand, the Basic Monthly Rent in advance, on or before the
first day of each calendar month throughout the Term commencing on the Commencement Date.
Concurrent with execution of this Lease, Tenant shall deposit with Landlord $43,997.95 as estimated
first month’s Basic Monthly Rent. THIS LEASE IS INTENDED TO BE AN ABSOLUTE “NET LEASE” AND TENANT
IS SOLELY RESPONSIBLE FOR THE CARE, MAINTENANCE, TAXES, INSURANCE, UTILITIES, REPAIR AND OPERATING
EXPENSES OF THE PREMISES, INCLUDING ALL COSTS THEREOF, AS THOUGH TENANT WERE THE OWNER OF THE
PREMISES, AND TENANT’S PRO RATA SHARE OF OPERATING EXPENSES EXCEPT AS SPECIFICALLY SET FORTH
HEREIN. All monetary obligations of Tenant under this Lease constitute “rent” under this Lease.

     8. Operating Expenses

          8.1 Definition of Operating Expenses. Tenant is responsible for payment of Tenant’s
Pro Rata Share of all Operating Expenses of the Project. As used in this Lease, the term “Operating
Expenses” means all costs and expenses paid or incurred by Landlord relative to the operation,
repair, restoration, replacement, maintenance, and management of the Project, including: (i) water,
sewage disposal, drainage, refuse collection and disposal, gas, electricity, and other utility
services, and the maintenance of all components, systems, and apparatus by which such utilities and
services are provided, (ii) general maintenance and repair of the landscaping, and structural
(subject to the limitations below) and non-structural components of the improvements located on the
Project and any janitorial, and security services (if any), (iii) expenses payable by Landlord
pursuant to the provisions of any recorded covenants, conditions, and restrictions, reciprocal
easement agreements, and any other recorded documents affecting the Project (other than Landlord’s
loan(s) secured by the Premises), (iv) all real property or real estate taxes, assessments,
association dues, and other impositions, whether general, special, ordinary, or extraordinary, and
of every kind and nature, which may be levied, assessed, imposed on the Project (“Real Estate
Taxes”), (v) any personal property taxes, assessments, or other impositions levied, assessed, or
imposed upon any personal property of Landlord used in connection with the Project, (vi) Insurance
Expenses (as defined below), (vii) property management fees to Landlord or its agent in the amount
of 3.5% of base rent payable by all tenants of the Project (including Tenant), and legal,
accounting, inspection, and consultation fees, and (viii) capital improvements required by any
change in Applicable Regulations, or other capital improvements, repairs, or replacements deemed
reasonably necessary by Landlord or

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appropriate to reduce Operating Expenses for the Project or Premises (but excluding any initial
improvements to the Project, such as Landlord’s Work); provided, however, any costs of such capital
improvements shall be amortized (including a commercially reasonable interest factor reasonably
determined by Landlord) over the anticipated useful life of such capital improvements.

          Notwithstanding the foregoing, Operating Expenses shall not include any of the following,:
(a) legal fees, brokerage commissions, and advertising costs incurred in connection with the sale
of any portion of the Project or the leasing of other premises within the Project; (b) costs
incurred in connection with damage or repairs to the extent reimbursed from any insurance policy
carried by Landlord in connection with the Project; (c) expenses for repair or replacement paid by
condemnation awards; (d) executive or management salaries; (e) the cost of offsite service
personnel to the extent that such personnel are not engaged in the management, operation, repair or
maintenance of the Project; (f) Landlord’s general overhead; (g) ground lease payments and all
principal, interest, loan fees, and other carrying costs related to any mortgage or deed of trust
encumbering the Project, unless such costs are directly attributable to Tenant’s, its agents’ or
employees’ activities in, on or about the Project, or as a result of a Tenant’s breach or default
under this Lease; (h) legal fees, accountant fees and other expenses incurred in disputes regarding
or associated with the enforcement or defense of Landlord’s title to or interest in the Project or
any part thereof; (i) capital costs incurred for the repair or replacement of the structural
aspects of the Building’s foundation, footings, structural support columns, exterior walls, and
roof structure (which does not include the roof membrane); and (j) any costs, expenses, or
liability incurred by Landlord on account of its obligations under Section 5.6 above.

          8.2 Payment of Operating Expenses. Landlord shall deliver to Tenant an annual
statement setting forth the estimated Operating Expenses Landlord expects to incur for the
applicable year (“Expense Statement”), Tenant shall pay one-twelfth of Tenant’s Pro Rata Share of
the amount set forth in the Expense Statement with each payment of Basic Monthly Rent. Tenant’s
payment obligations under this paragraph constitute additional rent under this Lease. If the sum of
Tenant’s payments on account of Operating Expenses during any calendar year exceeds the actual
Operating Expenses for the calendar year, then the excess will be credited against future Operating
Expenses due from Tenant, or paid directly to Tenant. If the sum of Tenant’s Operating Expense
payments for any calendar year is less than the actual Operating Expenses for the calendar year,
then Tenant shall pay Landlord the amount of the deficiency within 30 days after delivery of
Landlord’s statement reconciling the year’s Operating Expenses. Landlord’s delay in delivering any
Expense Statement or reconciliation statement will not release Tenant of its obligation to pay any
portion of the Operating Expenses.

     9. Utilities and Services. Landlord shall cause the Premises, the neighboring Premises
within the Project, and the Common Areas (the Common Areas include any cooling towers, chillers and
boilers, and any other equipment of Landlord for the common use of the Building) to be separately
metered for electricity and Tenant shall pay the cost of all separately-metered utilities furnished
to the Premises directly to the applicable utility provider. Tenant shall pay the Cost of all
utilities and services (including any connection charges and taxes thereon) furnished to the
Premises or used by Tenant, including electricity, water, heating, ventilating, air-conditioning,
oil, sewer, gas, telephone, communication services, trash collection, and janitorial services.
Landlord may furnish to the Premises any of the utilities and services set forth in the

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preceding sentence, in which case Tenant shall reimburse Landlord for Landlord’s cost of furnishing
such utilities and services. Landlord may not be held liable for failure to furnish any utilities
or services to the Premises when such failure results from causes beyond Landlord’s reasonable
control. If Landlord constructs new or additional utility facilities not included in Landlord’s
Work, including wiring, plumbing, conduits, or mains, resulting from Tenant’s changed or increased
utility requirements, Tenant shall promptly pay to Landlord the total cost of such items. The
discontinuance of any utilities or services, including Landlord’s discontinuance or failure to
provide any of the utilities or services furnished by Landlord to the Premises, shall neither be
deemed an actual or constructive eviction, nor release Tenant from its obligations under this Lease
including Tenant’s obligation to pay rent. Notwithstanding the foregoing, Landlord will be liable
to Tenant, as Tenant’s sole remedy, for 110% of the Basic Monthly Rent on account of any periods of
interruption of utility services to the Premises during normal business days suffered by Tenant as
the result of Landlord’s or its contractors’, agents’, employees’ or invitees’ gross negligence or
willful misconduct.

     10. Maintenance.

          10.1 Tenant’s Maintenance Obligations. Tenant shall at its sole cost (i) maintain,
repair, replace, and repaint, all in first class condition, all aspects and portions of the
Premises other than those for which Landlord is responsible under Section 10.2, (ii) arrange for
the removal of trash from the Premises, (iii) maintain service agreements reasonably satisfactory
to Landlord relative to maintenance, repair, and replacement of the laboratory gas equipment and
security systems within the Premises, (iv) maintain janitorial contracts (which contracts must at
least include semi-annual floor waxing, grill cleaning and, when needed, carpet cleaning) and pest
and termite control service agreements with respect to the Premises, reasonably acceptable to
Landlord. Tenant shall provide Landlord with current copies of all maintenance, service and
cleaning contracts throughout the Term. Tenant is additionally liable for any damage to the
Premises or the Project resulting from the acts or omissions of Tenant, Tenant’s Invitees or, with
respect to the Premises only, any other person not controlled by Landlord. If Tenant fails to
maintain, repair, replace, or repaint any portion of the Premises as provided above (after notice
from Landlord and a reasonable opportunity to complete the repair, maintenance, or replacement),
then Landlord may maintain, repair, replace, or repaint any such portion of the Premises or Project
and Tenant shall promptly reimburse Landlord for Landlord’s actual cost thereof, plus a supervisory
fee in the amount of five percent of such actual cost, which sum constitutes additional rent under
this Lease. Landlord, at Landlord’s sole discretion, may require Tenant to use specific contractors
or construction techniques for the purpose of maintaining warranties or the integrity of the
Premises provided such contractors or techniques are commercially reasonable. Tenant waives the
provisions of California Civil Code Section 1942 (or any successor statute), and any similar
principals of law with respect to Landlord’s obligations for tenantability of the Premises and
Tenant’s right to make repairs and deduct the expense of such repairs from rent.

          10.2 Landlord’s Maintenance Obligations. Landlord shall, subject to reimbursement in
accordance with Article 8 above, use its best efforts to maintain, repair, and replace the Common
Area and the structural and building systems of the Project, which are the foundations, exterior
walls, roof, and central HVAC, mechanical, electrical, and plumbing systems outside the Premises in
first class condition and good working order. Landlord’s failure

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to perform its obligations set forth in the preceding sentence will not release Tenant of its
obligations under this Lease, including Tenant’s obligation to pay rent, but Tenant may bring a
claim against Landlord for damages. Tenant waives the provisions of California Civil Code
Section 1942 (or any successor statute), and any similar principals of law with respect to
Landlord’s obligations for tenantability of the Premises and Tenant’s right to make repairs and
deduct the expense of such repairs from rent. If Landlord fails, within 30 days after receipt of
written notice of such failure or within such longer period of time if such failure is not
reasonably susceptible to cure within a 30-day period, to perform any of its material obligations
hereunder to Tenant and such failure is material and adverse to Tenant, then, Tenant may, as its
sole remedy, by process of law, compel Landlord to perform its obligations. Should Tenant be the
prevailing party in such process to compel, then Landlord will pay Tenant upon demand all
reasonable out-of-pocket costs incurred by Tenant pursuing such preceding remedy, including but not
limited to reasonable attorneys’ fees.

     11. Insurance.

          11.1 Public Liability and Property Damage Insurance. Tenant shall maintain throughout
the Term public liability and property damage insurance (i) with a single combined liability limit
and property damage limit of not less than $2,000,000.00 per occurrence, (ii) insuring (a) against
all liability of Tenant and Tenant’s Invitees arising out of or in connection with Tenant’s use or
occupancy of the Premises, including products liability and pollution coverage, and (b) performance
by Tenant of the indemnity provisions set forth in this Lease, and (iii) naming Landlord, its
agents, and any ground lessor or lender holding a security interest in the Premises (“Lender”) as
additional named insured, and (c) with umbrella coverage of $5 million. Not more frequently than
once every year, if, in the reasonable opinion of Landlord or at the request of any Lender, the
amount of such insurance at that time is not adequate, then Tenant shall increase such insurance as
reasonably required by Landlord (provided such increase is commercially reasonable in comparison to
the amounts and types of insurance required by landlords of similar properties in San Diego).

          11.2 Fire and Extended Coverage Insurance. Tenant shall maintain throughout the Term
on Tenant’s Alterations and Tenant’s Personal Property (as defined below) a policy of standard fire
and extended coverage insurance, with vandalism and malicious mischief endorsements, coverage with
respect to increased costs due to building ordinances, demolition coverage, boiler and machinery
insurance, and sprinkler leakage coverage, in each case to the extent of at least 100 percent of
full replacement value, and business interruption insurance (covering at least a one-year
interruption). Such “full replacement value” shall be determined by the company issuing such policy
at the time the policy is initially obtained. Not more frequently than once every two years, either
Landlord or Tenant may notify the other that it elects to have the replacement value re-determined
by an insurance company. Such re-determination shall be made promptly and in accordance with the
rules and practices of the Board of Fire Underwriters, or a like board recognized and generally
accepted by the insurance company, and Landlord and Tenant shall be promptly notified of the
results by the company. Such policy shall be promptly adjusted according to such re-determination.
Tenant shall additionally maintain full coverage plate-glass insurance on the Premises, in which
Landlord and any Lender be named as additional insureds.

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          11.3 Tenant’s Insurance Generally. Insurance required to be maintained by Tenant under
this Lease: (i) shall be issued as a primary policy (not contributed with, and in excess of
coverage Landlord may carry) by insurance companies authorized to do business in California with a
Best’s Rating of at least “A” and a Best’s Financial Size Category rating of at least “XIV,” as set
forth in the most current edition of “Best’s Insurance Reports” (unless otherwise approved by
Landlord); (ii) shall name Landlord and any Lender as additional named insureds, but the policy
must provide that notwithstanding the fact that Landlord is an additional insured, it is entitled
to recover under the policy for any loss suffered by Landlord by reason of Tenant’s negligence;
(iii) shall consist of “occurrence” based coverage, without provision for subsequent conversion to
“claims” based coverage; (iv) may not be cancelable or subject to reduction of coverage or other
modification except after 30-days’ prior written notice to Landlord and any Lender; and (v) may not
provide for a deductible or co-insurance provision in excess of $5,000.00. Tenant shall, at least
60 days before the expiration of each such policy, furnish Landlord with a renewal of or “binder”
extending the policy. Tenant shall promptly upon request deliver to Landlord copies of such policy
or policies or certificates evidencing the existence and amounts of such insurance together with
evidence of payment of premiums.

          11.4 Landlord’s Insurance. Landlord shall maintain throughout the Term policies of
insurance written by good and solvent insurance companies, worker’s compensation insurance as
required by law and shall maintain a standard special purpose all-risk property insurance policy in
an amount equal to the full replacement cost of the Building (including, without limitation, the
Landlord’s Work) with reasonable deductibles. Additionally, Landlord may maintain any of the
following insurance, in such amounts and with such limits as Landlord determines in its reasonable
discretion: (i) public liability and products liability insurance; (ii) fire and extended coverage
insurance, with vandalism and malicious mischief endorsements, coverage with respect to increased
costs due to building ordinances, demolition coverage, and sprinkler leakage coverage; (iii) boiler
and machinery insurance; (iv) fidelity insurance to the extent required by a Lender; (v) earthquake
insurance to the extent either required by a Lender or commonly maintained by owners or tenants of
similarly situated research/development properties in the general vicinity of the Building;
(vi) plate-glass insurance to the extent either required by a Lender or commonly maintained by
owners or tenants of properties similar to the Premises; (vii) pollution liability insurance; and
(viii) rental value insurance not to exceed 12 months rent. The premiums, costs, expenses, and
deductibles (or similar costs or charges) of or with respect to any such insurance (all of the
preceding, collectively, “Insurance Expenses”) are included in Operating Expenses.

          11.5 Waiver of Subrogation. Landlord and Tenant release each other, Tenant’s Invitees,
and Landlord’s guests, invitees, customers and licensees (collectively, “Landlord’s Invitees”) from
all claims for damage, loss, or injury to the Premises, to Tenant’s Personal Property, and to the
fixtures and Alterations of either Landlord or Tenant in or on the Premises to the extent the
damage, loss or injury is covered by any insurance policies carried by Landlord and Tenant and in
force at the time of such damage. Landlord and Tenant shall each use its best efforts to cause all
insurance policies obtained by it pursuant to this Lease to provide that the insurance company
waives all right of recovery by way of subrogation against Landlord and Tenant in connection with
any damage, loss, or injury covered by such policy.

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     12. Taxes. Tenant shall pay before delinquency all taxes, assessments, license fees,
and other charges that are levied or assessed against, or based on the value of, Tenant’s personal
property installed or located in or on the Premises including trade fixtures, furnishings,
equipment, and inventory (collectively, “Tenant’s Personal Property”) and any real property or real
estate taxes, assessments, and other impositions, whether general, special, ordinary, or
extraordinary, and of every kind and nature, which may be separately levied, assessed, imposed upon
or with respect to the Premises (to the extent separately assessed from the remainder of the
Building). On demand by Landlord, Tenant shall furnish Landlord with satisfactory evidence of such
payments. If any such taxes, assessments, license fees, or other charges are levied against
Landlord or Landlord’s property, or if the assessed value of the Premises is increased by the
inclusion of a value placed on Tenant’s Personal Property, then Tenant, on demand, shall
immediately reimburse Landlord for the sum of such taxes, assessments, license fees, and other
charges so levied against Landlord which amounts constitute additional rent under this Lease.
Landlord may pay such taxes, assessments, license fees, or other charges or such proportion, and
receive such reimbursement, regardless of the validity of the levy.

     13. Alterations. Tenant may make alterations, improvements, additions, installations,
or changes to the Premises (any of the preceding, “Alterations”) only if: (i) Tenant first obtains
Landlord’s written consent (which consent may not unreasonably be withheld, conditioned, or
delayed), (ii) Tenant complies with all conditions, which may be imposed by Landlord, including but
not limited to Landlord’s selection of specific contractors or construction techniques (but
Landlord may not unreasonably impose such restrictions), and (iii) Tenant pays to Landlord
the reasonable costs and expenses of Landlord for architectural, engineering, or other consultants
which reasonably may be incurred by Landlord in determining whether to approve any such
Alterations. At least 30 days before making any Alterations, Tenant shall submit to Landlord, in
written form, proposed detailed plans of such Alterations. Tenant shall, before commencing any
Alterations, at Tenant’s sole cost, (i) acquire (and deliver to Landlord a copy of) a permit from
appropriate governmental agencies to make such Alterations (any conditions of which permit Tenant
shall comply with, at Tenant’s sole cost, in a prompt and expeditious manner), (ii) provide
Landlord with 10 days’ prior written notice of the date the installation of the Alterations is to
commence, which notice must explicitly remind Landlord to post and record an appropriate notice of
non-responsibility, and (iii) obtain (and deliver to Landlord proof of) reasonably adequate workers
compensation insurance with respect to any of Tenant’s employees installing or involved with such
Alterations (which insurance Tenant shall maintain in force until completion of the Alterations).
All Alterations shall upon installation become the property of Landlord and shall remain on and be
surrendered with the Premises on termination of this Lease, except that Landlord may, at its
election, require Tenant to remove any or all of the Alterations, by so notifying Tenant in writing
at the time Landlord consents to the Alteration, in which event, Tenant shall, at its sole cost, on
or before the Expiration Date or earlier termination of this Lease, repair and restore the Premises
to the condition of the Premises prior to the installation of the Alterations which are to be
removed. Tenant shall pay all costs for Alterations and other construction done or caused to be
done by Tenant and Tenant shall keep the Premises free and clear of all mechanics’ and
materialmen’s lien’s resulting from or relating to any Alterations or other construction. The term
“Alteration” does not include any of the following that are paid for and installed by Tenant and
Tenant may remove any of the following that are paid for and installed by Tenant at any time:
Tenant’s personal property, equipment, capital equipment, fume hoods, fume snorkels, de-ionized
water skids, vacuum pumps,

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dehumidification units, uninterruptible power supplies, warehouse racks, parts racks, scientific
research equipment, portable cold rooms, moveable unattached lunch room and office furnishings and
equipment, telecommunications and data equipment (other than cabling), machine shop tools and
portable equipment, portable glass wash equipment, equipment monitoring systems, air compressors
and emergency generators (collectively, the “Equipment”). Notwithstanding the foregoing, if
installation of any of the Equipment materially effects any of the improvements within the Project,
the installation itself (but not the Equipment) is considered an Alteration and subject to the
requirements of this Article 13. Landlord acknowledges that Landlord has no lien, right, claim,
interest or title in or to the Equipment, except to the extent remaining at the Project after
termination of this Lease. Tenant may grant a security interest in the Equipment. Within 14 days
following Tenant’s written request, Landlord shall execute an acknowledgement of the foregoing in a
commercially reasonable form for the benefit of the secured party under a security interest granted
in accordance with the preceding sentence, allowing the secured party or equipment lessor access to
the Premises for removal of the Equipment, subject to Landlord’s reasonable restrictions.

     14. Surrender of Premises and Holding Over. On the Expiration Date or earlier
termination of this Lease, Tenant shall (i) surrender to Landlord the Premises in good and clean
condition (normal wear and tear excepted), along with all keys to the Premises and Project
(including any keys to any exterior or interior doors), (ii) remove all of Tenant’s Personal
Property and perform all repairs and restoration required by the removal of any Alterations (to the
extent required under this Lease) or Tenant’s Personal Property, (iii) take all action, and pay all
costs, necessary to provide Landlord with an environmental site assessment effective as of the
Expiration Date, front a reputable, licensed environmental engineering company reasonably
acceptable to Landlord and conducted and reported in accordance with the attached Exhibit G (the
“Exit Assessment”) establishing that the Premises and Common Area are free of any Hazardous
Materials, and (iv) “close out” all operating permits, including any hazardous material and
radioactive permits to the extent required by or appropriate under applicable law. Landlord may
elect to retain or dispose of in any manner any Alterations or Tenant’s Personal Property that
Tenant does not remove from the Project on the Expiration Date or earlier termination of this Lease
as required by this Lease by giving written notice to Tenant. Any such Alterations or Tenant’s
Personal Property that Landlord elects to retain or dispose of will vest in Landlord immediately on
notice to Tenant. Tenant waives all claims against Landlord for any damage to Tenant resulting
front Landlord’s retention or disposition of any such Alterations or Tenant’s Personal Property.
Tenant is liable to Landlord for Landlord’s costs for storing, removing or disposing of any such
Alterations or Tenant’s Personal Property. If for any reason Tenant fails to surrender the Project
to Landlord on the Expiration Date or earlier termination of this Lease, Tenant shall indemnify
Landlord against all actions, liabilities, damages, losses, costs, expenses, attorneys’ fees and
claims resulting from such failure, including any claim for damages made by a succeeding tenant. If
Tenant, with Landlord’s consent, remains in possession of the Premises after the Expiration Date or
earlier termination of this Lease, such possession by Tenant shall be deemed to be a month-to-month
tenancy terminable on 30-days’ written notice given at any time by Landlord or Tenant. During any
such month-to-month tenancy, Tenant shall pay, as Basic Monthly Rent, 125 percent of the Basic
Monthly Rent in effect immediately before the Expiration Date or earlier termination of this Lease,
as the case may be, unless Landlord and Tenant mutually agree otherwise in writing. All provisions
of this Lease other than those pertaining to Term apply to such month-to-month tenancy.

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     15. Default. The occurrence of any of the following constitutes a material default and
breach of this Lease by Tenant:

          15.1 Tenant’s failure to make any payment of rent within three days after written notice from
Landlord to Tenant that the payment is due. No grace period before the imposition of a late charge
extends the date when such rent is due and payable, and Tenant is in default under this Lease if
such payment is not timely made.

          15.2 Tenant’s failure to observe or perform any other provision of this Lease for a period of
30 days after written notice of such failure from Landlord to Tenant; provided, however, such
notice is in lieu of, and not in addition to, any notice required under applicable unlawful
detainer statute; and provided further, however, that if the nature of Tenant’s default is such
that more than 30 days are required for its cure, then Tenant is not deemed to be in default if
Tenant commences such cure within the 30-day period and thereafter diligently prosecutes such cure
to completion within 180 days after Landlord’s written notice.

     If Landlord accepts Tenant’s cure of a default after the applicable cure period specified
above by acknowledging in writing its acceptance, such default is deemed permanently cured.

     16. Landlord’s Remedies. Landlord is entitled to the following remedies if Tenant
commits a default or breach under this Lease; these remedies are not exclusive, but are cumulative
and in addition to any remedies provided elsewhere in this Lease, or now or later allowed by law.

          16.1 Continuation of Lease. No act by Landlord (including the acts set forth in the
next sentence) terminates Tenant’s right to possession unless Landlord notifies Tenant in writing
that Landlord elects to terminate Tenant’s right to possession. As long as Landlord does not
terminate Tenant’s right to possession, Landlord may (i) continue this Lease in effect,
(ii) continue to collect rent when due and enforce all the other provisions of this Lease,
(iii) enter the Premises and relet them, or any part of them, to third parties for Tenant’s
account, for a period shorter or longer than the remaining term of this Lease, and (iv) have a
receiver appointed to collect rent and conduct Tenant’s business. Tenant shall immediately pay to
Landlord all costs Landlord incurs in such reletting, including brokers’ commissions, attorneys’
fees, advertising costs, and expenses of remodeling the Premises for such reletting. If Landlord
elects to relet all or any portion of the Premises as permitted above, rent that Landlord receives
from such relating will be applied to the payment of, in the following order and priority, (i) any
indebtedness from Tenant to Landlord other than Basic Monthly Rent due front Tenant, (ii) all costs
incurred by Landlord in the reletting, and (iii) Basic Monthly Rent (and, if applicable, percentage
rent) due and unpaid under this Lease. After applying the payments as referred to above, any sum
remaining from the rent Landlord receives from the reletting will be held by Landlord and applied
in payment of future rent as it becomes due under this Lease. Tenant will not be entitled to any
excess rent received by Landlord unless and until all obligations of Tenant under this Lease,
including all future obligations, are satisfied in full.

          16.2 Termination of Tenant’s Right to Possession. In the event of such breach or
default by Tenant, Landlord may terminate Tenant’s right to possession of the Premises at any time,
by notifying Tenant in writing that Landlord elects to terminate Tenant’s right to

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possession. On termination of this Lease, Landlord has the right to recover from Tenant (i) the
worth at the time of the award of the unpaid rent which had been earned at the time of such
termination, (ii) the worth at the time of the award of the amount by which the unpaid rent which
would have been earned after such termination until the time of award exceeds the amount of such
loss of rent that Tenant proves could have been reasonably avoided, (iii) the worth at the time of
the award of the amount by which the unpaid rent for the balance of the Term after the time of
award (had there been no such termination) exceeds the amount of such loss of rent that Tenant
proves could be reasonably avoided, and (iv) any other amount necessary to compensate Landlord for
all detriment proximately caused by Tenant’s failure to perform Tenant’s obligations under this
Lease or in the ordinary course of things would be likely to result therefrom. The “worth at the
time of the award” of the amounts referred to in Clauses (i) and (ii) above is to be computed by
allowing interest at the Default Rate, as set forth below. The “worth at the time of the award” of
the amount referred to in Clause (iii) above is to be computed by discounting such amount at the
discount rate of the Federal Reserve Bank of San Francisco at the time of award.

          16.3 Landlord’s Right to Cure Default. Landlord, at any time after Tenant commits a
default or breach under this Lease after notice to Tenant (unless notice is impractical under the
circumstance), may cure such default or breach at Tenant’s sole cost, in a commercially reasonable
manner. If Landlord at any time, by reason of Tenant’s default or breach, pays any sum or does any
act that requires the payment of any sum, such sum, to the extent reasonably incurred, shall be due
immediately from Tenant to Landlord at the time such sum is paid, and constitutes additional rent
under this Lease.

          16.4 Enforcement Costs. On demand, Tenant shall pay Landlord all reasonable costs and
expenses incurred by Landlord in connection with collecting any amounts and damages owing by Tenant
under this Lease, or to enforce any provision of this Lease, including reasonable attorneys’ fees,
whether or not any action is commenced by Landlord.

     17. Late Payments. Late payment by Tenant to Landlord of rent will cause Landlord to
incur costs not contemplated by this Lease, the exact amount of which would be impracticable or
extremely difficult to fix. Costs include processing, collection and accounting charges, and late
charges that may be imposed on Landlord by the terms of any deeds of trust covering the Premises.
Therefore, if any rent or other payment is not received by Landlord within five days after its due
date, then, notwithstanding any cure rights of Tenant (including those under Article 15 above)
without any requirement for notice to Tenant, Tenant shall pay to Landlord an additional sum of
five percent of such overdue amount as a late charge. Such late charge represents a fair and
reasonable estimate of the costs that Landlord will incur by reason of any late payment by Tenant,
and therefore this paragraph is reasonable under the circumstances existing at the time this Lease
is made. Acceptance of such late charge by Landlord does not constitute a waiver of Tenant’s
default with respect to such overdue amount, nor prevent Landlord from exercising any of the other
rights and remedies available to Landlord under this Lease. In addition to the late charge payable
by Tenant, if any rent is not paid within 30 days of the date such rent is due, then Tenant shall
pay to Landlord interest on the overdue rent at the rate equal to the “reference rate” announced
from time to time by Bank of America, NT&SA (if such reference rate ceases to be announced, then a
reasonably comparable “prime rate” shall be utilized, selected by Landlord), plus 10% per annum, or
the maximum rate permitted by law,

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whichever is less (the “Default Rate”). Such interest shall additionally accrue and be payable by
Tenant relative to any other amounts payable by Tenant to Landlord under the provisions of this
Lease which are not paid when due. All late charges and interest under this paragraph constitute
additional rent under this Lease. If a late charge is payable under this Lease, whether or not
collected, for two installments of Basic Monthly Rent, Operating Expense, or other rent due under
this Lease during any 12-month period, Tenant’s monthly payments will automatically become due and
payable quarterly in advance, rather than monthly. All monies paid to Landlord under the preceding
sentence may be commingled with other monies of Landlord and will not bear interest. If Tenant
breaches any provision of this Lease, then any balance remaining from funds paid to Landlord under
the provisions of this paragraph may, at Landlord’s election, be applied to the payment of any
monetary default of Tenant.

     18. Security. Tenant shall immediately deliver the Security Deposit to Landlord to
secure the performance by Tenant of its obligations under this Lease, including Tenant’s
obligations (i) to pay rent, (ii) to repair damages caused by Tenant or Tenant’s Invitees, (iii) to
clean the Premises on the termination of this Lease, and (iv) to remedy any other defaults by
Tenant in the performance of any of its obligations under this Lease. If Tenant commits any default
under this Lease, Landlord may use the Security Deposit to cure such defaults (after expiration of
the applicable cure period under Article 15 above), and to compensate Landlord for damage suffered
by Landlord from such defaults, including attorneys’ fees and costs incurred by Landlord. Tenant
shall promptly pay to Landlord the amount necessary to replenish any portion of the Security
Deposit so used by Landlord. Following the Expiration Date or earlier termination of this Lease,
and within the time frame required by applicable law, Landlord shall deliver to Tenant, at Tenant’s
last known address, any portion of the Security Deposit not used by Landlord in accordance with
this paragraph. Landlord may commingle the Security Deposit with Landlord’s other funds and
Landlord will not pay interest on such Security Deposit to Tenant. As additional security for
Tenant’s obligations under this Lease, Tenant shall grant Landlord a first-priority security
interest in certain trade fixtures included in the equipment list contemplated under Section 2.5
above. The particular trade fixtures must have a minimal value of $100,000.00 and be particularly
identified on a list mutually acceptable to Landlord and Tenant. The security interest must be
granted before the Commencement Date for the vivarium and be documented in accordance with a form
reasonably prescribed by Landlord and perfected by an appropriate financing statement or other
appropriate means reasonably acceptable to Landlord.

     19. Destruction. If the Premises is totally or partially destroyed during the Term,
rendering the Premises totally or partially inaccessible or unusable, then (i) Landlord shall
restore the Premises to substantially the same condition as it was in immediately before such
destruction (including Landlord’s Work), (ii) Landlord will not be required to restore Tenant’s
Alterations or Tenant’s Personal Property unless they are an integral part of the Premises and
specifically covered by insurance proceeds received by Landlord, such excluded items being the sole
responsibility of Tenant to restore, (iii) the destruction will not terminate this Lease, and
(iv) all obligations of Tenant under this Lease will remain in effect, except that the Basic
Monthly Rent will be abated or reduced, between the date of the destruction and the date of
completion of restoration, by the ratio of (a) the area of the Premises rendered unusable or
inaccessible by the destruction to (b) the area of the Premises before the destruction.
Notwithstanding the foregoing, Tenant may terminate this Lease by so notifying Landlord in writing
within 30 days after the

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destruction if (x) then-existing laws do not permit such restoration, (y) the destruction occurs
during the last year of the Term, or (z) Tenant reasonably establishes that substantial completion
of the restoration will not occur within 12 months after the date of the destruction. Conversely,
notwithstanding anything to the contrary in this Lease, Landlord may terminate this Lease by so
notifying Tenant in writing on or before the later of 90 days after the destruction or 30 days
after Landlord’s receipt of the proceeds from insurance maintained by Landlord, if
(A) then-existing Applicable Regulations do not permit such restoration, (B) the destruction occurs
during the last year of the Term, (C) the destruction exceeds 25 percent of the then-replacement
value of the Building, or (D) Landlord reasonably determines that the cost of the restoration
exceeds the amount of insurance proceeds relating to the destruction actually received by Landlord
(excluding deductibles contemplated by the applicable insurance policy, if any). If Tenant or
landlord terminates this Lease in accordance with this paragraph, then (1) Landlord has no
obligation to restore the Premises, (2) Landlord retains all insurance proceeds relating to such
destruction, and (3) this Lease terminates as of 30 days after the notice of termination from
Tenant or Landlord. If Landlord restores the Premises as provided above, then Tenant waives the
provisions of California Civil Code Sections 1932(2) and 1933(4) or any successor statute with
respect to any destruction of the Premises.

     20. Condemnation. If during the Term there is any taking of all or any part of the
Premises or any interest in this Lease by the exercise of any governmental power, whether by legal
proceedings or otherwise., by any entity or individual having the power of condemnation (any of the
preceding a “Condemnor”), or a voluntary sale or transfer by Landlord to any Condemnor, either
under threat of condemnation or while legal proceedings for condemnation are pending (any of the
preceding, a “Condemnation”), then this paragraph applies. A temporary Condemnation of all or any
part of the Premises for less than 180 days does not constitute a Condemnation under this
paragraph, but the Basic Monthly Rent is abated as to the portion of the Premises affected during
the temporary Condemnation. If the Condemnation is of the entire Premises, then this Lease
terminates on the date the Condemnor takes possession of the Premises (the “Date of Condemnation”).
If the Condemnation is of some, but not all, of the Premises, then this Lease remains in effect,
except that, if the remaining portion of the Premises is rendered unsuitable for Tenant’s continued
use of the Premises, as reasonably determined by Tenant, then Tenant may elect to terminate this
Lease by so notifying Landlord in writing (the “Termination Notice”) within 30 days after the date
that the nature and extent of the Condemnation have been determined. Such termination becomes
effective on the earlier of (i) the date that is 30 days after the Termination Notice, and (ii) the
Date of Condemnation. If Tenant does not give Landlord the Termination Notice within the 30-day
period, then all obligations of Tenant under this Lease remain in effect, except that (unless the
Premises are restored as set forth below) Basic Monthly Rent will prospectively be reduced by the
ratio of (a) the area of the Premises taken to (b) the area of the Premises immediately before the
Date of Condemnation. Notwithstanding anything to the contrary in this paragraph, if within 20 days
after Landlord’s receipt of the Termination Notice Landlord notifies Tenant that Landlord at its
cost will add to the remaining Premises so that the area of the Premises will be substantially the
same after the Condemnation as they were before the Condemnation, and Landlord commences the
restoration promptly and completes it within 180 days after Landlord so notifies Tenant, then all
obligations of Tenant under this Lease remain in effect, except that Basic Monthly Rent shall be
abated or reduced during the period from the Date of Condemnation until the completion of such
restoration by the ratio of (A) the area of the Premises taken to (B) the area of the Premises
immediately before the Date of

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Condemnation. Unless Landlord restores the Premises pursuant to the preceding sentence, or unless
Tenant gives Landlord the Termination Notice within the relevant 30-day period, Tenant at its sole
cost shall accomplish any restoration required by Tenant to use the Premises. All compensation,
sums, or anything of value awarded, paid, or received on a total or partial Condemnation (the
“Award”) belongs to and must be paid to Landlord (except as provided below). Tenant has no right to
any part of the Award, and Tenant hereby assigns to Landlord all of Tenant’s right, title, and
interest in and to any part of the Award, except that Tenant may receive from the Award any sum
paid expressly to Tenant from the Condemnor for Tenant’s loss of Tenant’s Personal Property,
Equipment, and relocation costs. Landlord and Tenant waive the provisions of any statute (including
California Code of Civil Procedure Section 1265.130 or any successor statute) that allows Landlord
or Tenant to petition the applicable court to terminate this Lease in the event of a partial taking
of the Premises.

     21. Assignment and Other Transfers. Without Landlord’s prior written consent, which
may not unreasonably be withheld, none of the following may occur (or be permitted by Tenant to
occur), voluntarily, involuntarily, by operation of law, or otherwise (any of the following, a
“Transfer”): any assignment, sublease, disposition, sale, concession, license, mortgage,
encumbrance, hypothecation, pledge, collateral assignment, or other transfer, by Tenant of this
Lease, any interest in this Lease, or all or any portion of the Premises. No Transfer releases or
discharges Tenant from any liability, whether past, present, or future, under this Lease and Tenant
continues to remain primarily liable under this Lease (and Tenant shall execute a guaranty of the
transferee’s obligations in form and substance satisfactory to Landlord [a “Lease Guaranty"]).
Tenant irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all
rent and other amounts from any Transfer, and landlord, as assignee and as special attorney-in-fact
for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and
other amounts and apply them toward Tenant’s obligations under this Lease; except that, unless
Tenant defaults under this Lease, Tenant may collect such rent and other amounts. Tenant shall
promptly reimburse Landlord for Landlord’s reasonable costs (less any payment made by Tenant with
Landlord as set forth above) of reviewing, consenting to, rejecting or consummating any proposed
Transfer, including reasonable attorneys’ fees. Tenant shall promptly pay to Landlord one-half of
all rents and other consideration, of whatever nature, payable by the transferee (or receivable by
Tenant) pursuant to any Transfer, which exceeds (1) if a sublease of a portion of the Premises, the
portion of the Basic Monthly Rent that is allocable to the portion of the Premises subleased (such
allocation based on the area of the portion subleased), or (2) if any other Transfer, the Basic
Monthly Rent, in each case after deduction of all of Tenant’s reasonable Transfer expenses
(including leasing commissions, attorney’s fees and tenant improvements).

          Any provision in this Lease to the contrary notwithstanding, Landlord’s consent is not
required for any of the following transfers (each of which shall be a “Permitted Transfer”): (a) to
any person(s) or entity who controls, is controlled by or is under common control with the original
Tenant executing this Lease, (b) to any entity resulting from the merger, consolidation or other
reorganization with the original Tenant executing this Lease, whether or not Tenant is the
surviving entity or (c) to any person or legal entity which acquires all or substantially all of
the assets or stock of the original Tenant executing this Lease (each of the foregoing, a “Tenant
Affiliate”); provided that before the transfer is effective, (x) the Tenant Affiliate must assume,
in full, the obligations of Tenant under this Lease and Tenant shall execute a Lease Guaranty, (y)

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Landlord shall be given advance written notice of the transfer, and (z) the use of the Premises by
the Tenant Affiliate must be as set forth in this Lease. For purposes of this Article 21, a public
offering of Tenant stock is a Permitted Transfer and the term “control” means the power to direct
or cause the direction of all management, affairs and policies of a person or entity.

     22. Access by Landlord. Landlord and any of Landlord’s agents or employees may enter
the Premises at all reasonable times, during normal business hours if feasible under the
circumstances, and after reasonable notice, if feasible under the circumstances, (i) to determine
whether the Premises are in good condition and whether Tenant is complying with its obligations
under this Lease, (ii) to do any necessary maintenance or make any restoration to the Premises that
Landlord has the right or obligation to perform, (iii) to serve, post, or keep posted any notices
required or allowed under this Lease, (iv) to post “for sale” or “for rent” or “for lease” signs,
(v) to show the Premises to brokers, agents, prospective buyers, prospective tenants (during the
last six months of the Term), or other persons interested in a listing of, financing, purchasing,
or occupying the Premises, (vi) to review Tenant’s Hazardous Materials handling, confirm chemical
inventory list, and otherwise inspect the Premises for Hazardous Materials contamination or
potential contamination, including an environmental audit of the Premises (the costs of which will
be borne by Tenant whenever (a) they reveal any contamination, chemical or environmental
irregularities in violation of Applicable Regulations, and (b) they follow an uncured default by
Tenant under this Lease after the applicable cure period), and (vii) to shore the foundations,
footings, and walls of the Project, and to erect scaffolding and protective barricades around and
about the Project and Premises, but not so as to prevent entry to the Premises, and to do any other
act or thing necessary for the safety or preservation of the Premises or Project if any excavation
or other construction is undertaken or is about to be undertaken on any adjacent property or nearby
street. In the event of an emergency Landlord may enter the Premises, at any time, without prior
notice to Tenant. Landlord’s rights under this paragraph extend, with Landlord’s consent, to the
owner of adjacent property on which excavation or construction is to take place and the adjacent
property owner’s agents, employees, officers, and contractors, Landlord will not be liable for any
inconvenience, disturbance, loss of business, nuisance, or other damage arising out of any entry on
the Premises as provided in this paragraph except damage resulting directly from the grossly
negligent acts of Landlord or Landlord’s Invitees. Tenant will not be entitled to any abatement or
reduction of rent because of the exercise by Landlord of any rights under this paragraph.

     23. Indemnity and Exemption of Landlord from Liability. Tenant shall defend,
indemnify, and hold harmless Landlord and Landlord’s agents, affiliates, owners, employees, and
independent contractors (collectively, “Landlord Indemnitees”) against all Claims (as defined
below) and all costs, expenses, and attorneys’ fees incurred in the defense or handling of any such
Claims or any action or proceeding brought on any of such Claims. For purposes of this Lease,
“Claims” means all liabilities, damages, losses, costs, expenses, reasonable attorneys’ fees, and
claims (except to the extent they result from Landlord’s grossly negligent acts or willful
misconduct) arising from or which seek to impose liability under or because of (i) Tenant’s or
Tenant’s Invitees’ use of the Premises or Project, (ii) the conduct of Tenant’s business, (iii) any
activity, work, or things done, permitted, or suffered by Tenant or any of Tenant’s Invitees in or
about the Premises, Project or elsewhere, (iv) any breach or default in the performance of any
obligation to be performed by Tenant under this Lease, (v) any negligence of Tenant or any of
Tenant’s Invitees, or (vi) any event, act or omission arising on, out of, under or above the

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Premises during the Term, except to the extent any of the foregoing is caused by Landlord’s gross
negligence or willful misconduct. Except to the extent caused by Landlord’s grossly negligent acts
or willful misconduct, Tenant assumes all risk of, Tenant waives all claims against all Landlord
Indemnitees in respect of, and no Landlord Indemnitee is liable for, any of the matters set forth
above in this paragraph or any of the following: injury to Tenant’s business, loss of income from
such business, or damage or injury to the goods, wares, merchandise, or other property or the
person of Tenant, Tenant’s Invitees, or any other persons in, on, or about the Project, whether
such damage, loss, or injury is caused by or results from criminal acts, fire, steam, electricity,
gas, water, rain, the breakage, leakage, obstruction or other defects of pipes, sewer lines,
sprinklers, wires, appliances, plumbing, air-conditioning or lighting fixtures, or any other cause,
conditions arising about the Premises, or other sources or places, and regardless of whether the
cause of such damage, loss, or injury or the means of repairing such damage, loss, or injury is
inaccessible to Tenant. “Claims” also includes those arising from or relating to: (i) any
discharges, releases, or threatened releases of noise, pollutants, contaminants, herbicides,
pesticides, insecticides, or hazardous or toxic wastes, substances, or materials, or any other
chemicals or substances which are regulated by any governmental agency or are harmful to human
health (any of the preceding a “Hazardous Material”) into ambient air, water, or land by Tenant or
Tenant’s Invitee’s, or otherwise from, on, under, or above the Premises after the Commencement Date
or caused by Tenant or Tenant’s Invitee on, under, around or above the Project, (ii) the
manufacture, processing, distribution, use, treatment, storage, disposal, transport, or handling of
pollutants, contaminants, or hazardous or toxic wastes, substances, material, by Tenant or Tenant’s
Invitees, or otherwise from, on, or under, the Premises after the Commencement Date or caused by
Tenant or Tenant’s Invitee on, under, around or above the Project, or (iii) a violation of any
environmental law or regulation on, under, or above the Premises after the Commencement Date or
caused by Tenant or Tenant’s Invitee on, under, around or above the Project.

     24. Hazardous Substances. Although Tenant has reviewed a Phase I Environmental Site
Assessment prepared for Dwyer Curlett by AES Due Diligence dated September 5, 2002, (the “Entrance
Assessment”) with respect to the Premises (and Landlord makes no representation or warranty
regarding such report). Landlord shall indemnify Tenant for losses incurred by Tenant resulting
from the contamination of the Premises of Hazardous Materials to the extent Tenant establishes that
the contamination existed on the Premises before the Commencement Date (unless caused by Tenant or
Tenant’s Invitees). Neither Tenant nor any of Tenant’s Invitees may use, manufacture, store, or
dispose of any Hazardous Materials anywhere within the Project, except in accordance with all
Applicable Regulations and as identified in Tenant’s Operations Plan, and only if all claims,
liabilities and damages arising from such Hazardous Materials are either adequately covered (and
the Hazardous Materials permitted) by Landlord’s insurance or covered (and the Hazardous Materials
permitted) by supplemental insurance or endorsements appropriate to such use reasonably acceptable
to Landlord. If the Premises is contaminated by any Hazardous Material during the Term or if any
part of the Project is contaminated by any Hazardous Material used by Tenant or Tenant’s Invitee,
then (1) Tenant shall promptly notify Landlord in writing of such contamination, and (2) Landlord
may elect to either (A) demand that Tenant perform all remediation required by Landlord (to
Landlord’s satisfaction and at Tenant’s sole cost, necessary to return the Premises and Project to
at least as good a condition as they were in as of the Commencement Date, which Tenant shall
immediately do upon receipt of notice from Landlord, or (B) proceed to cause such investigation,
clean-up,

- 20 -

 

and remediation work which Landlord reasonably deems necessary or desirable to be undertaken,
whereupon the entire cost thereof (plus a supervisory fee equal to five percent of such cost) will
be payable by Tenant to Landlord upon demand as additional rent. If Tenant does not promptly
commence and diligently pursue such remediation, then Landlord may perform or cause to be performed
such remediation and Tenant shall immediately, upon demand, pay the cost thereof, plus a
supervisory fee in the amount of five percent of such cost. The parties obligations and liability
under this paragraph shall survive the termination of Tenant’s tenancy and the Term of this Lease,
except that nothing contained in this paragraph shall be deemed to impose liability on Tenant for
any problem arising after the Term of this Lease or later vacation of the Premises by Tenant or
Tenant’s Invitees, provided neither Tenant nor Tenant’s Invitees contributed to such problem during
the Term of the Lease.

     25. Security Measures. Tenant acknowledges (i) that the Basic Monthly Rent does not
include the cost of any security measures for any portion of the Premises or Project (ii) that
Landlord has no obligation to provide any security measures, (iii) that Landlord has made no
representation to Tenant regarding the safety or security of the Premises or Project, and (iv) that
Tenant is solely responsible for providing any security it deems necessary to protect itself, its
property, and Tenant’s Invitees in, on, or about the Premises and the Project. Landlord has no duty
to warn Tenant of any criminal acts or dangerous conduct that has occurred in or near the Project,
regardless of Landlord’s knowledge of such crimes or conduct.

     26. Common Area Changes. Landlord may (i) close any of the Common Area to the extent
required in the opinion of Landlord’s legal counsel to prevent a dedication of any of the Common
Area or the accrual of any rights to any person or to the public in and to any portion of the
Common Area, (ii) close, temporarily, any of the Common Area for maintenance purposes,
(iii) designate other property outside the boundaries of the Project to become part of the Common
Area, (iv) close off or otherwise utilize portions of the Common Area while constructing
improvements or making repairs or alterations to any portion of the Project, and (v) make any
changes to the Common Area, or any part of the Project, including changes to buildings or other
improvements, the addition of new buildings or other improvements, or changes in the location of
driveways, entrances, exits, vehicular parking spaces, or the direction of the flow of traffic;
provided that in no event shall Landlord reduce the number of parking spaces available to Tenant by
more than 5.0% (but no such percentage limit applies if the reduction results from the need to
comply with Applicable Regulations) or take any actions that will materially impact Tenant’s use of
the Common Area. Landlord, as owner of the Project, reserves the right from time to time, to use
portions of the Common Area for, among other things, entertainment, advertising, displays, the
leasing of kiosks, or such other uses, commercial or otherwise, so long as such uses do not
materially adversely affect Tenant’s use of the Premises.

     27. Subordination and Attornment. This Lease and Tenant’s rights under this Lease are
subject and subordinate to any mortgage, deed of trust, ground lease, or underlying lease (and to
all renewals, modifications, consolidations, replacements, or extensions thereof), now or hereafter
affecting the Premises. The provisions of this paragraph are self-operative, and no further
instrument of subordination is required. In confirmation of such subordination, however, Tenant
shall promptly execute and deliver any instruments that Landlord, any Lender, or the lessor under
any ground or underlying lease, may request to evidence such subordination.

- 21 -

 

Notwithstanding the preceding provisions of this paragraph, if any ground lessor or Lender elects
to have this Lease prior to the lien of its ground lease, deed of trust, or mortgage, and gives
written notice thereof to Tenant, then this Lease is deemed to be prior to the lien of such ground
lease or mortgage and such ground lease, deed of trust, or mortgage shall be deemed to be
subordinate to this Lease, and thereafter if such Lender or lessor succeeds to the rights of
Landlord under this Lease, whether by foreclosure, deed in lieu of foreclosure or otherwise, then
(i) such successor landlord will not be subject to any offsets or defenses which Tenant might have
against Landlord, (ii) such successor landlord will not be bound by any prepayment by Tenant of
more than one month’s installment of rent, (iii) such successor landlord will not be subject to any
liability or obligation of Landlord except those arising after such succession, (iv) Tenant shall
attorn to and recognize such successor landlord as Tenant’s landlord under this Lease, (v) Tenant
shall promptly execute and deliver any instruments that may be necessary to evidence such
attornment, provided the same is in a commercially reasonable form and (vi) on such attornment,
this Lease shall continue in effect as a direct lease between such successor landlord and Tenant.
Within ten days after Landlord’s request, Tenant shall execute and deliver a Subordination,
Non-Disturbance, and Attornment Agreement (“SNDA”) in the applicable Lender’s standard form.
Conversely, at Tenant’s request, Landlord shall diligently seek an SNDA from its Lender(s).

     28. Estoppel Certificates. Within 10 days after notice from Landlord, Tenant shall
execute and deliver to Landlord, a certificate stating (i) that this Lease is unmodified and in
full force and effect, or in full force and effect as modified, and stating all modifications,
(ii) the then-current Basic Monthly Rent, (iii) the dates to which Basic Monthly Rent has been paid
in advance, (iv) the amount of any security deposit, prepaid rent or other payment constituting
rent which has been paid (including Operating Expenses), (v) whether or not Tenant or Landlord is
in default under this Lease and whether there currently exist any defenses or rights of offset
under the Lease, and (vi) such other matters as Landlord shall reasonably request. Tenant’s failure
to deliver the certificate within the 10-day period shall be conclusive upon Tenant for the benefit
of Landlord, and any successor in interest to Landlord, any Lender or proposed Lender, and any
purchaser of the Premises that, except as may be represented by Landlord, this Lease is unmodified
and in full force and effect, no rent has been paid more than 30 days in advance, and neither
Tenant nor Landlord is in default under this Lease. Tenant irrevocably constitutes and appoints
Landlord as its special attorney-in-fact to execute and deliver such certificate to any third party
if Tenant fails to deliver such certificate within the 10-day period.

     29. Waiver. No delay or omission in the exercise of any right or remedy of Landlord in
the event of any default by Tenant shall impair such right or remedy or be construed as a waiver.
The receipt and acceptance by Landlord of delinquent rent does not constitute a waiver of any
default other than the particular rent payment accepted. Landlord’s receipt and acceptance from
Tenant, on any date (the “Receipt Date”), of an amount less than the amount due on such Receipt
Date, or to become due at a later date but applicable to a period before the Receipt Date, does not
release Tenant of its obligation (i) to pay the full amount due on such Receipt Date or (ii) to pay
when due the full amount to become due at a later date but applicable to a period before such
Receipt Date. No act or conduct of Landlord, including the acceptance of the keys to the Premises,
constitutes an acceptance by Landlord of the surrender of the Premises by Tenant before the
Expiration Date. Only a written notice from Landlord to Tenant stating Landlord’s election to
terminate Tenant’s right to possession of the Premises constitutes

- 22 -

 

acceptance of the surrender of the Premises and accomplishes a termination of this Lease.
Landlord’s consent to or approval of any act by Tenant requiring Landlord’s consent or approval may
not be deemed to waive or render unnecessary Landlord’s consent to or approval of any other or
subsequent act by Tenant. Any waiver by Landlord of any default must be in writing and does not
constitute a waiver of any other default concerning the same or any other provision of this Lease.
Tenant waives any rights granted to Tenant under California Code of Civil Procedure Section 1179,
California Civil Code Section 3275, and any successor statute(s). Tenant represents and warrants
that if Tenant breaches this Lease and, as a result, this Lease is terminated, Tenant will not
suffer any undue hardship as a result of the termination and, during the Term, will make such
alternative or other contingency plans to provide for its vacation of the Premises and relocation
in the event of such termination. Tenant acknowledges that Tenant’s waivers set forth in this
paragraph are a material part of the consideration for Landlord’s entering into this Lease and that
Landlord would not have entered into this Lease in the absence of such waivers.

     30. Brokers. Tenant represents that no real estate broker, agent, finder, or other
person is responsible for bringing about or negotiating this Lease except for the Broker and
neither Landlord nor Tenant has dealt with any real estate broker, agent, finder, or other person,
relative to this Lease in any manner, other than the Broker. Each party shall defend, indemnify,
and hold harmless the other party against all liabilities, damages, losses, costs, expenses,
attorneys’ fees and claims arising from any claims that may be made against the indemnified party
by any real estate broker, agent, finder, or other person (other than as set forth above), alleging
to have acted on behalf of or to have dealt with the indemnifying party. Landlord shall compensate
Broker in accordance with a separate written agreement between Landlord and the Broker.

     31. Easements. Landlord may from time to time grant such easements, rights and
dedications, and cause the recordation of parcel maps, easement and operating agreements, and
restrictions affecting the Premises or Project so long as such actions do not unreasonably
interfere with Tenant’s use of the Premises or Project or increase Tenant’s obligations under this
Lease. Tenant shall promptly sign any documents or instruments to accomplish the foregoing upon
request by Landlord. Tenant irrevocably appoints Landlord as Tenant’s special attorney-in-fact to
execute and deliver such documents or instruments on behalf of Tenant if Tenant refuses or fails to
do so.

     32. Limitations on Landlord’s Liability. If Landlord is in default of this Lease, and
as a consequence Tenant recovers a money judgment against Landlord, such judgment shall be
satisfied only out of the proceeds of sale received upon execution of such judgment and levy
against the right, title, and interest of Landlord in the Project, and out of rent or other income
from the Project receivable by Landlord or out of the consideration received by Landlord from the
sale or other disposition of all or any part of Landlord’s right, title, and interest in the
Project. The foregoing limitation shall not apply to Landlord’s misappropriation of the Security
Deposit. Neither Landlord nor Landlord’s affiliates, members, managers, shareholders, officers,
directors, agents, or employees shall be personally liable for any deficiency. Tenant’s rights to
pursue Landlord’s interest in the Project arise only after a judgment is entered in the applicable
tribunal against Landlord. Tenant waives any right to record a lis pendens against any portion of
the Premises. In the event of an alleged default by Landlord under this Lease, Tenant may in no

- 23 -

 

event offset its rent, or perform Landlord’s obligations (except in an emergency), or deduct any
amounts from Tenant’s rental obligations under this Lease; Tenant’s Sole remedies are to bring an
appropriate action for specific performance against Landlord or to sue Landlord for damages, and
only after giving Landlord written notice and a reasonable period of time within which to cure its
default.

     33. Sale or Transfer of Premises. If Landlord sells or transfers any portion of the
Premises, Landlord, on consummation of the sale or transfer, shall be released from any liability
thereafter accruing under this Lease. If any security deposit or prepaid rent has been paid by
Tenant, Landlord may transfer the security deposit or prepaid rent to Landlord’s
successor-in-interest and on such transfer Landlord shall be discharged from any further liability
arising from the security deposit or prepaid rent.

     34. Quitclaim Deed. Tenant shall execute and deliver to Landlord on the Expiration
Date or earlier termination of this Lease, promptly on Landlord’s request, a quitclaim deed to the
Premises and Project, in recordable form, designating Landlord as transferee.

     35. No Merger. The voluntary or other surrender of this Lease by Tenant, or a mutual
cancellation of this Lease, or a termination by Landlord, shall not work a merger, and shall, at
the option of Landlord, terminate any existing subleases or may, at the option of Landlord, operate
as an assignment to Landlord of any such subleases.

     36. Miscellaneous.

          36.1 Financial Statements. On Landlord’s written request (which may be made no more
than four times in any 12 -month period), Tenant shall promptly furnish to Landlord, from time to
time, financial statements for Tenant certified as accurate and complete by Tenant’s CFO or CEO,
reflecting Tenant’s then current financial conditions. Such financial statements shall include a
current balance sheet and a profit and loss statement covering the most recent 12- month period
available. Tenant shall cooperate with any efforts by Landlord to obtain private credit ratings for
Tenant.

          36.2 Governing Law, Venue and Jurisdiction. This Lease is governed by and construed in
accordance with the laws of the State of California, irrespective of California’s choice-of-law
principles. All actions and proceedings arising in connection with this Lease must be tried and
litigated exclusively in the State and Federal courts located in the County of San Diego, State of
California, which courts have personal jurisdiction and venue over each of the parties to this
Lease for the purpose of adjudicating all matters arising out of or related to this Lease. Each
party authorizes and accepts service of process sufficient for personal jurisdiction in any action
against it as contemplated by this paragraph by registered or certified mail, return receipt
requested, postage prepaid, to its address for the giving of notices set forth in this Lease.

          36.3 Further Assurances. Each party to this Lease shall execute and deliver all
instruments and documents and take all actions as may be reasonably required or appropriate to
carry out the purposes of this Lease.

          36.4 Time of Essence. Time and strict and punctual performance are of the essence with
respect to each provision of this Lease.

- 24 -

 

          36.5 Attorney’s Fees. The prevailing party(ies) in any litigation, arbitration,
mediation, bankruptcy, insolvency or other proceeding (“Proceeding”) relating to the enforcement or
interpretation of this Lease may recover from the unsuccessful party(ies) all costs, expenses, and
reasonable attorney’s fees (including expert witness and other consultants’ fees and costs)
relating to or arising out of (a) the Proceeding (whether or not the Proceeding proceeds to
judgment), and (b) any post-judgment or post-award proceeding including, without limitation, one to
enforce or collect any judgment or award resulting from the Proceeding. All such judgments and
awards shall contain a specific provision for the recovery of all such subsequently incurred costs,
expenses, and reasonable attorney’s fees.

          36.6 Modification. This Lease may be modified only by a contract in writing executed
by the party to this Lease against whom enforcement of the modification is sought.

          36.7 Prior Understandings. This Lease and all documents specifically referred to and
executed in connection with this Lease: (a) contain the entire and final agreement of the parties
to this Lease with respect to the subject matter of this Lease, and (b) supersede all negotiations,
stipulations, understandings, agreements, representations and warranties, if any, with respect to
such subject matter, which precede or accompany the execution of this Lease.

          36.8 Interpretation. Whenever the context so requires in this Lease, all words used in
the singular may include the plural (and vice versa) and the word “person” includes a natural
person, a corporation, a firm, a partnership, a joint venture, a trust, an estate or any other
entity. The terms “includes” and “including” do not imply any limitation. No remedy or election
under this Lease is exclusive, but rather, to the extent permitted by applicable law, each such
remedy and election is cumulative with all other remedies at law or in equity. “Applicable
Regulations” means all of the applicable laws and regulations and covenants, conditions and
restrictions governing the Premises (but Landlord will not vote for or consent to any new or
modified covenants, conditions or restrictions governing the Premises that materially impact
Tenant, without first obtaining Tenant’s prior written consent). The paragraph headings in this
Lease: (a) are included only for convenience, (b) do not in any manner modify or limit any of the
provisions of this Lease, and (c) may not be used in the interpretation of this Lease. All
provisions, whether covenants or conditions, to be performed or observed by Tenant shall be deemed
to be both covenants and conditions.

          36.9 Partial Invalidity. Each provision of this Lease is valid and enforceable to the
fullest extent permitted by law. If any provision of this Lease (or the application of such
provision to any person or circumstance) is or becomes invalid or unenforceable, the remainder of
this Lease, and the application of such provision to persons or circumstances other than those as
to which it is held invalid or unenforceable, are not affected by such invalidity or
unenforceability.

          36.10 Notices. Each notice and other communication required or permitted to be given
under this Lease (“Notice”) must be in writing. Notice is duly given to another party upon:
(a) hand delivery to the other party, (b) receipt by the other party when sent by facsimile to the
address and number for such party set forth in Article 2 (provided, however, that the Notice is not
effective unless a duplicate copy of the facsimile Notice is promptly given by one of the other
methods permitted under this paragraph), (c) three business days after the Notice has been

- 25 -

 

deposited with the United States postal service as first class certified mail, return receipt
requested, postage prepaid, and addressed to the party as set forth in Article 2, or (d) the next
business day after the Notice has been deposited with a reputable overnight delivery service,
postage prepaid, addressed to the party as set forth in Article 2 with next-business-day delivery
guaranteed, provided that the sending party receives a confirmation of delivery from the
delivery-service-provider. Each party shall make a reasonable, good faith effort to ensure that it
will accept or receive Notices to it that are given in accordance with this paragraph. A party may
change its address for purposes of this paragraph by giving the other party(ies) written notice of
a new address in the manner set forth above.

          36.11 Drafting Ambiguities. Each party to this Lease and its legal counsel have
reviewed and revised this Lease. The rule of construction that ambiguities are to be resolved
against the drafting party or in favor of the party receiving a particular benefit under an
agreement may not be employed in the interpretation of this Lease or any amendment to this Lease.

          36.12 Third Party Beneficiaries. Nothing in this Lease is intended to confer any
rights or remedies on any person or entity other than the parties to this Lease and their
respective successors-in-interest and permitted assignees.

	 	 	 	 	 	 	 
	LANDLORD:	 	VPI OBERLIN I, L.P., a California limited partnership	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	VPI Oberlin GPI, L.L.C., a California limited
liability company, its sole general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Daniel J. Ryan
 

Daniel J. Ryan, President
	 	 
	 
	 	 	 	 	 	 
	TENANT:	 	PHENOMIX CORPORATION, a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Chris Burnley
 

Chris Burnley, Chief Business Officer
	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Julie Rayle
 

Julie Rayle, Vice President, Assistant
Secretary, and Treasurer
	 	 

- 26 -

 

Exhibit “A-1” — The Project 

Lots 32 and 33 of Lusk Industrial Park Unit No. 1, in the City of San Diego, County of San Diego,
State of California, according to Map thereof No. 9694, filed in the Office of the County Recorder
of San Diego County, June 27, 1980.

EXCEPTING THEREFROM all coal, oil, gas, petroleum and other hydrocarbon substances in and under
such property.

- A-1-1 -

 

Exhibit “A-2” — Landlord’s Work 

     Landlord, at its sole cost and expense, shall cause improvements to be made to the Project in
two phases (collectively “Landlord’s Work”). The first phase of Landlord’s Work (“Phase 1”)
includes the majority of Landlord’s Work, consisting of the general office and lab space depicted
on the attached Exhibit C (the “Phase 1 Floor Plan”) and the improvements described on the attached
Exhibit D (the “Phase 1 Specifications”). The second phase of Landlord’s Work is construction of a
vivarium (the “Vivarium Phase”) in accordance with the. floor plan depicted on the attached Exhibit
E (the “Vivarium Floor Plan”) and the improvements described on the attached Exhibit F (the
“Vivarium Specifications”). Landlord’s Work is intended to provide Tenant with a “turn-key”
facility such that upon Tenant taking possession of the Premises with the applicable phase of
Landlord’s Work completed, a tenant would be able to conduct business in the Premises without
further modifications to the improvements at the Premises (other than installation of personal
property, equipment., and trade fixtures); provided, however, the items identified in Exhibits C,
D, E, or F as “excluded” are not to be included in Landlord’s Work (and if Tenant requests the
inclusion of any such items, or any other items not explicitly identified on such exhibits as being
included in the applicable portion of Landlord’s Work, such inclusion constitutes a
Tenant-requested change to Landlord’s Work). Tenant may request changes to Landlord’s Work that
will not result in delay of more than 30 days to Substantial Completion of Landlord’s Work, and
Landlord may not unreasonably withhold its consent to such changes (but any resulting delay, even
if less than 30 days, constitutes Tenant Delay). If such changes are requested, Landlord shall
provide Tenant with an estimate of the cost of the changes as soon as possible. Within one week
after receiving Landlord’s estimate, Tenant may retract its requested change, in which case
Landlord will proceed with Landlord’s Work and all delay, if any, resulting from the request will
be Tenant Delay (but the foregoing is not intended to imply that any request for a change will
necessarily result in a stoppage or delay of Landlord’s Work); otherwise, if Landlord does not
receive Tenant’s retraction within one week after providing Tenant the estimate for the increased
costs (or, if before such deadline Tenant waives its rights to retract). Landlord shall proceed
with Landlord’s Work as modified by the requested change, in which case Tenant will be responsible
for the increased costs, if any, incurred by Landlord for such changes and Tenant shall pay such
excess directly to Landlord within one week after Landlord’s written request for payment; provided,
however, Tenant may elect in writing within that one-week period to require Landlord to contribute
such excess costs (including any TI Overage described below) up to an aggregate of $100,000.00 (the
“Additional Allowance”), in which case the Basic Monthly Rent will be increased as described above.
In approving or disapproving of Tenant-requested changes to Landlord’s Work, Landlord may take into
account the effect of such changes on the future marketability of the Premises (whether
independently or integrated with the balance of the Building).

     Within 30 days after the date of this Lease, Landlord shall provide Tenant for its review and
approval detailed mechanical, electrical, and plumbing plans (“MEP Plans”) for Phase 1 of
Landlord’s Work. Tenant has five days after its receipt of the MEP Plans to disapprove of them
(which disapproval may only be made if Tenant establishes that the MEP Plans do not meet the
requirements necessary to serve the equipment contemplated by Exhibits C anti D). If Tenant
disapproves of the MEP Plans, Landlord shall diligently work revising the MEP Plans to comport with
Tenant’s needs as indicated on the attached Exhibits C and D.

- A-2-1 -

 

     Tenant understands that its choice for equipment and utility location plan for the vivarium
may affect the scope of the Vivarium Phase of Landlord’s Work contemplated by Exhibits E and F (For
example, Tenant may select equipment that requires utilities exceeding the capacity provided for in
the attached Exhibit F.) Tenant shall provide Landlord with a derailed equipment list and utility
location plan (identifying the location and nature of ionized water service, telephone and data,
nitrogen, compressed air, vacuum and electrical outlets) for the vivarium as soon as possible, but
by no later than August 14, 2003. Landlord shall then submit the equipment list and utility plan to
Landlord’s engineers and design professionals, and ultimately to the applicable trade contractors
to prepare for permitting and construction of the Vivarium Phase of Landlord’s Work. Landlord shall
require the trade contractors to provide a written bid specifically identifying the difference
between the cost charged by such contractor to fulfill the specifications under Exhibits E and F
versus any modifications or enhancements made necessary by Tenant’s equipment list or utility plan.
The aggregate of such additional costs, plus a 10% supervisory fee, constitutes a“T1 Overage”.
Landlord shall notify Tenant of the TI Overage as soon as reasonably available and tenant shall
promptly pay Landlord an amount equal to the TI Overage. Promptly after receiving such payment,
Landlord shall diligently proceed to obtain the governmental permits necessary to construct the
Vivarium Phase of Landlord’s Work (the “Vivarium Permit”).

- A-2-2 -

 

EXHIBIT B

[MAP]

- B-1 -

 

Exhibit “D” — Phase 1 Specifications 

Landlord’s Work is intended to include easily divisible, generic (for the industry) improvements
reflected on the floor plan attached to the Lease as Exhibit C (the “Lab/Office Floor Plan”),
reasonably necessary for Tenant and future biotechnology and chemistry tenants to conduct their
businesses on the Premises (excluding specialized improvements and equipment not commonly used by
biotechnology or chemistry tenants in general for office and generic (for the industry) laboratory
space). In case of omissions, spec will generally conform to same as Kemia’s. Landlord’s Work will
include only those items depicted on the Floor Plan and described below:

	1.	 	STATE AND LOCAL CODE COMPLIANCE

All design and construction shall conform to all Federal, State and Local building codes and
ordinances to include but not be limited to the most current version of the following
documents.

	 	1.	 	1997 Uniform Building Code
	 
	 	2.	 	2001 California Building Code
	 
	 	3.	 	2001 Uniform Plumbing Code
	 
	 	4.	 	2001 Uniform Mechanical Code
	 
	 	5.	 	1999 National Electrical Code
	 
	 	6.	 	2000 Uniform Fire Code
	 
	 	7	 	1994 ADA Standards for Accessible Design
	 
	 	8.	 	2001 Title 24, California’s Energy Efficiency Standards
	 
	 	9.	 	California Division of Occupational Safety and Health
	 
	 	10.	 	San Diego Municipal Code

	2.	 	PLANNING

Project planning will generally encompass a multi-tenancy subject to Landlord’s discretion.
General space planning and utility segregation arrangements shall be incorporated into the
design for demisability.

	3.	 	ARCHITECTURAL

	 	A.	 	FLOORING/CASEWORK

	 	 	 
	General Requirements

	 	Moisture vapor emission testing
(VET) shall be conducted by a
qualified testing agency of concrete
slabs scheduled to be covered with a
flooring material. Any areas of the
concrete slab which exceed the
finish flooring
manufacturer/installer warranty
limits for allowable moisture vapor
emission will be properly treated
with vapor retarders such as “Floor
Seal Technology and Alkalinity
Control System Applications” or
similar applications to obtain
warranty.

- D-1 -

 

	 	 	 
	Lobby/Reception

	 	Ceramic/stone Tile or other similar hard surface material.
	 
	 	 
	Office and Admin

	 	Carpeted with a minimum 28-oz./yd2 or better
tile or glue-down product throughout with a 4” rubber
wall base. Carpet pads may be used in areas where daily
cart and hand-truck traffic is not anticipated.
	 
	 	 
	Laboratories

	 	VCT with multiple colors of same product used throughout.
	 
	 	 
	Glasswash

	 	Epoxy flooring.
	 
	 	 
	Tissue Culture &

Equipment

	 	VCT with 4” rubber base.
	 
	 	 
	Facility Support and
Storage Areas

	 	VCT with multiple colors of same product used throughout.
	 
	 	 
	Casework

	 	Metal casework in chemistry laboratory with Trespa
counter tops. Chem surf over plastic laminates or better
in biology and Tissue Culture laboratory. Plastic
laminate in break room

	 	B.	 	WALL CONSTRUCTION

	 	 	 
	Non-Load Bearing 

Rated

	 	Rated walls, ceilings and other enclosures shall be
constructed of “Type-X” gypsum drywall board (thickness
and number of layers per code) on metal studs sized
appropriately by structural calculations for the height
and width and class of wall required. “Shaft-Wall” may
also be utilized where allowed by local building
officials.
	 
	 	 
	Non-Load Bearing 

Non-Rated

	 	Non-Rated walls, ceilings and other enclosures shall be
constructed of 5/8” thick gypsum drywall over 20 gauge by
3-5/8” minimum width metal studs
	 
	 	 
	 

	 	Non-rated Walls in Conference Rooms, Executive offices,
Computer Rooms, and other support spaces needing
additional sound attenuation or ceiling grid layout shall
be constructed to underside of roof framing.
	 
	 	 
	 

	 	At electrical room walls adjoining tenant space EMF
shielding to be installed as part of the wall systems.

- D-2 -

 

	 	 	 
	Interior Walls 

Supporting Casework 

or Fixtures

	 	All interior walls that will be used to mount
casework, appliances, or fixtures will have backing
installed within the wall appropriate to support
this item’s weight and forces acting applied to it.

	 	C.	 	WALL FINISHES

	 	 	 
	All Areas Except
Storage and Facility
Support

	 	Wall finishes in these areas shall be a minimum of
Level-3 smoothness capable of receiving paint
without texture or wall coverings.
	 
	 	 
	Facility Support and
Storage Areas
Throughout

	 	Wall finishes in these areas shall be a minimum of
Level-3 smoothness capable of receiving paint.

	 	D.	 	DOORS/HARDWARE/INTERIOR WINDOWS

	 	 	 
	Office/Admin

	 	Doors shall generally be stain grade doors, 7 foot
or taller. Doorframe finish, color and hardware
shall be selected by Landlord.
	 
	 	 
	Laboratory Areas

	 	Doors shall generally be paint grade, 7 foot, solid
core wood doors. Doorframes shall be hollow metal.
Door finish, frame finish, color(s) and hardware
shall be selected by Landlord
	 
	 	 
	 

	 	Interior windows per Exhibit “C”.
	 
	 	 
	Hardware

	 	Type-D (Heavy Duty Commercial) Schlage hardware or
better approved by Landlord.
	 
	 	 
	Windows

	 	As shown on Exhibit “C”.

	 	E.	 	CEILINGS

	 	 	 
	Administrative Areas

	 	Ceilings in the reception area, conference area(s),
and private offices shall all be 2’ by 4’ tegular,
suspended acoustical tiles in a metal T-bar.
	 
	 	 
	 

	 	Ceilings in the other areas of the administrative
areas shall be no larger than a 2’ by 4’ suspended
acoustical tiles in a metal T-bar grid set a minimum
height of ten feet above the finish floor where such
minimum height is practicable or achievable.
	 
	 	 
	Laboratory Areas

	 	2’ by 4’ suspended vinyl roc tiles in a metal T-bar.
	 
	 	 
	Cell Culture:

	 	Gypsum Board.

- D-3 -

 

	 	 	 
	Skylights:

	 	Four skylights, approximately 4’ x 4’. Two each to the Open
Office (201) and two each in the Open Tech Area (217).

	4.	 	STRUCTURAL

The tenant may not alter or attach objects to the structural components (foundation, slab,
walls, columns, beams, purlins, etc.) of the facility in any way before acquiring the
following:

	 	A.	 	Approval by the Landlord or the Landlord’s representative.
	 
	 	B.	 	Structural design calculations and construction documents from a
Licensed Structural Engineer in the State of California.

	5.	 	MECHANICAL

The mechanical system will include: two (2) cooling towers and two (2) associated pumps
outside on grade; two (2) chillers and associated pumps within an indoor chiller room; and two
(2) air Handlers serving the Lab areas for both tenants, heating hot water boilers, boiler
pumps, vacuum, and air compressor located on a structural steel platform located above the
roofline. The size, orientation and composition of the mechanical platform (the “Mechanical
Platform”) will be sufficient to hold appropriate mechanical equipment and any future
equipment.

	 	A.	 	CENTRAL PLANT

	 	 	 
	Laboratory Areas

	 	Air Handlers serving lab areas shall be manufactured by Energy
Labs, or approved equal. Unit quality level shall be consistent
with a 15-year useful life expectancy and rated at
high-efficiency. Coils exposed to outdoor air shall be copper
finned or factory coated aluminum fins for marine environment.
Air Handlers shall be sized such that the units are capable of
providing 100% outside air to the space at minimum of 12 air
changes per hour. All supporting mechanical equipment
(including, but not limited to) piping, ductwork, coil size,
chilled water capacity, heating water capacity, and controls
shall be sized and installed accordingly. All units shall be
controlled via Direct Digital Controls.
	 
	 	 
	Air Handler,
Piping, and Duct

	 	Sizing shall all be calculated and designed to satisfy typical
laboratory heating and cooling demands plus a margin of 15%.
	 
	 	 
	Central Plant 

Equipment

	 	The chilled water system shall consist of a water-cooled
chiller/chiller plant having the following items:
	 
	 	 
	 

	 	1. Two (2) CARRIER water cooled, screw chillers of 165 tons each;
	 
	 	 
	 

	 	2. Two (2) 200-ton EVAPCO cooling towers with two (2) pumps.

- D-4 -

 

	 	B.	 	PACKAGING SYSTEM

	 	 	 
	Administrative Area

	 	Package heat pumps/AC units shall be manufactured by
Trane, Carrier or approved equivalent. Unit quality
level shall be consistent with a 15-year useful life
expectancy. Structural analysis and upgrades shall be
made accordingly. All units shall be rated at high
efficiency (SEER = 12.00 or higher).
	 
	 	 
	IT/Phone Room

	 	Rooftop package cooling unit to be connected to
emergency power and operate 24/7 genset/Emergency
power by Tenant (see note 7.A.5.)
	 
	 	 
	Package Units

	 	Controlled by programmable thermostats.

	6.	 	PLUMBING SERVICES

All plumbing fixtures throughout the building will tie in directly to the City of San Diego
sanitary sewer system. Caustic or acidic waste is not allowed to be disposed of down any
fixtures (e.g. coffee grounds, undiluted DI water, etc.).

	 	A.	 	Bulk N2 (Shared between tenants)

1. Landlord shall specify outdoor location and provide housekeeping pad per tenant
provided N2 tank.

2. Size of N2 tank shall not exceed 4-0diameter.

3. Point of use filtering is not included.

4. Piping for N2 service shall be as follows: Point of connection into building from
tenant provided N2 tank and copper piping and connections to fume hood turrets and lab
bench turrets where indicated in plan, lab benches.

	 	B.	 	D1 (Shared between tenants)

1. DI piping shall provide service to fixtures as indicated in plan.

2. Shared with Kemia and to be worked out with Kemia.

	 	C.	 	Compressed air (Shared between tenants)

1. Compressor will be located on Mechanical Platform

- D-5 -

 

2. Compressed air will be plumbed to fume hood turrets.

3. System will provide clean, dry compressed air.

4. Point of use filtering is not included.

5. Shared with Kemia and to be worked out with Kemia.

	 	D.	 	House Vacuum (Tenant Dedicated) Vacuum will be located on rooftop.
	 
	 	E.	 	Natural Gas (Metered Separately), if commercially reasonable In biology laboratory

	7.	 	ELECTRICAL

	 	A.	 	POWER

1. Each Tenant area shall be wired with its pro rata amperage of the total service.
Electrical service shall be separately metered to accommodate the building being divided
into 2 tenant suites.

2. Total Electrical design load shall be designed to code, not exceed 60% of total
capacity (at design or connected loads ) and be easily expandable to create additional
capacity.

3. Standard minimum for convenience outlets for normal office use throughout is 4 plugs.

4. 2-voice/data drop per office/cubicle/room occupant in office, administrative and
support areas.

5. Exhaust fans and air handlers as shown on MEP drawings will be wired for emergency
power and stubbed with a transfer switch on a pad at the northeast corner of site.
Emergency Generator by Tenant not to exceed 300KW. Enclosure, raceway, and conductor by
Landlord (conductors from Genset to ATS should be by tenant as sizing will based on
Genset size).

6. Each of the eight (8) fume hoods being supplied shall have two (2) 20-amp circuit
terminated at two (2) duplex receptacles at each side of the superstructure for a total
of four (4), and another 20-amp circuit for the vacuum cabinet beneath, and an
additional 20-amp circuit will be installed and terminated for the fan and light as
supplied by the manufacturer of the fume hood.

7. Each of the nine (9) lab benches being supplied will have four (4) 20-amp circuits,
eight (8) quad receptacle devices and one (1) duplex at the end of the bench.
Additionally, a total of two (2) duplex outlets at kneeholes beneath the bench.

- D-6 -

 

8. Electrical plug strip convenience outlets, equipment power and connection to be
provided as shown on Exhibit C. J. Box provided for systems furniture.

	 	B.	 	LIGHTING

1. Administrative Area Lighting shall be T-8 lamps with electronic ballast mounted in
T-bar grid) with skylighter-fixtures, and AB switching.

2. Administrative Area Lighting in each office or separate room shall be individually
switched with motion sensor override.

3. Open Laboratory Lighting shall consist of linear pendant fixtures (indirect), down
lights, and fume hood lighting.

	8.	 	FIRE PROTECTION

	 	A.	 	ALARM PANEL

1. Connected to existing fire alarm control panel per code.

2. Semi-recessed sprinkler heads with chrome or white escutcheons throughout.

3. Cover plates on wall-mounted strobes shall be in accordance with Applicable Law.

4. Fire extinguisher cabinets shall be white or brushed 626 finish.

5. CA code minimum fire, life, safety system will be provided.

	9.	 	OTHER INCLUSIONS

1. Cold room

2. Flammable cabinets where indicated in the Hanson Drawings (Part of Hoods/Benches)

3. Data, telephone and security wiring. Allowance of S50,000.

	10.	 	EXCLUSIONS

1. Future fume hoods

2. Future benches

3. System furniture

4. Biosafety cabinets (Provisions by Landlord for one Thimble Connection where requested)

- D-7 -

 

5. Lab equipment

6. Emergency generator- (equipment only) and wiring from emergency generator to transfer
switch.

7. Thimble connections other than provided by Landlord.

- D-8 -

 

EXHIBIT E

[MAP]

- E-1 -

 

Exhibit “F” — Vivarium Specifications 

          Landlord’s Work is intended to include improvements reflected on the floor plan attached to
the Lease as Exhibit E (the “Vivarium Floor Plan”), reasonably necessary for Tenant and future
biotechnology and chemistry tenants to conduct their businesses on the Premises. Landlord’s Work
will include those items depicted on the Vivarium Floor Plan and described below:

	1.	 	STATE AND LOCAL CODE COMPLIANCE

All design and construction shall conform to all Federal, State and Local building codes and
ordinances to include but not be limited to the most current version Of the following
documents.

	 	1.	 	1997 Uniform Building Code
	 
	 	2.	 	2001 California Building Code
	 
	 	3.	 	2001 Uniform Plumbing Code
	 
	 	4.	 	2001 Uniform Mechanical Code
	 
	 	5.	 	1999 National Electrical Code
	 
	 	6.	 	2000 Uniform Fire Code
	 
	 	7.	 	1994 ADA Standards for Accessible Design
	 
	 	8.	 	2001 Title 24, California’s Energy Efficiency Standards
	 
	 	9.	 	California Division of Occupational Safety and Health
	 
	 	10.	 	San Diego Municipal Code

	2.	 	ARCHITECTURAL

	 	A.	 	FLOORING/CASEWORK/BENCHES

	 	 	 
	General Requirements

	 	Moisture vapor emission testing (VET)
shall be conducted by a qualified
testing agency of concrete slabs
scheduled to be covered with a flooring
material. Any areas of the concrete
slab which exceed the finish flooring
manufacturer/installer warranty limits
for allowable moisture vapor emission
will be properly treated with vapor
retarders such as “Floor Seal
Technology and Alkalinity Control
System Applications” or similar
applications to obtain warranty.
	 
	 	 
	All areas

	 	Expoxy flooring throughout.
	 
	 	 
	Casework

	 	Metal Casework as shown on Exhibit E
(no other overhead cupboards, soffits,
or additional tech spaces)

- F-1 -

 

	 	 	 
	Benches

	 	Locker room bench (1)

	 	B.	 	WALL CONSTRUCTION

	 	 	 
	Non-Load Bearing Rated

	 	Rated walls, ceilings and other
enclosures shall be constructed of
“Type-X” gypsum drywall board
(thickness and number of layers per
code) on metal studs sized
appropriately by structural
calculations for the height and
width and class of wall required.
	 
	 	 
	Non-Load Bearing 
Non-Rated

	 	Non-Rated walls, ceilings and other
enclosures shall be constructed of
5/8” thick gypsum drywall over 20
gauge by 3-5/8” minimum width metal
studs
	 
	 	 
	Interior Walls Supporting 
Casework
or Fixtures

	 	All interior walls that will be used
to mount casework, appliances, or
fixtures will have backing installed
within the wall appropriate to
support this item’s weight and
forces acting applied to it.

	 	C.	 	WALL FINISHES

	 	 	 
	All Areas

	 	Wall finishes in these areas shall
be a minimum of Level-4 smoothness
capable of receiving paint without
texture or wall coverings. Paint
shall be epoxy. PVC wall bumpers at
holding rooms, corridors, cage wash
rooms and quarantine.

	 	D.	 	DOORS/HARDWARE

	 	 	 
	All Areas

	 	Doors shall be hollow metal, 7 foot.
Doorframes shall be hollow metal.
Door finish, frame finish, color(s)
and hardware shall be selected by
Landlord
	 
	 	 
	Hardware

	 	Type-D (Heavy Duty Commercial)
Schlage hardware or better approved
by Landlord.

	 	E.	 	CEILINGS

	 	 	 
	All Areas

	 	Hardlids 5/8” thick gypsum drywall
over 20 gauge by 3-5/8” minimum
width metal studs at 9’ AFF. Paint
shall be epoxy

	3.	 	STRUCTURAL

The tenant may not alter or attach objects to the structural components (foundation, slab,
walls, columns, beams, purlins, etc.) of the facility in any way before acquiring the
following:

	 	A.	 	Approval by the Landlord or the Landlord’s representative.

- F-2 -

 

B. Structural design calculations and construction documents from a Licensed Structural
Engineer in the State of California.

	4.	 	MECHANICAL (VIVARIUM)

	 	A.	 	AIR HANDLER

The vivarium will be served by (1) dedicated, roof mounted, constant volume, 5800 CFM Energy
Labs air handling unit (or a unit with capacity to provide air changes as described in
paragraph 4.F.) comprised of moisture eliminator, 95% internal filtration, CHW coil, supply
fan, fan section and will deliver 100% outside air to the space.

	 	B.	 	EXHAUST FAN

The vivarium will be exhausted via (1) single dedicated roof mounted utility exhaust fan
(biosafety cabinets will not be exhausted).

	 	C.	 	ZONING.

All of the vivarium spaces will be comprised of (6) zones, the following five zones will be
the responsibility of the Landlord: (1) the Mice Holding and Procedure Rooms (245 and 247),
(2) the Rat Holding and Procedure Rooms (246 and 248), (3) the Quarantine Area (241), (4) the
Glass cage wash Rooms (242 and 244), (5) the Gowning Vestibule (250), Receiving Room (240),
Feed and Bedding Room (243) and Toilet Room (251 within one zone.

The sixth and final zone and associated reheat coils serving Mice Holding (249), will be paid
for by the Tenant.

	 	D.	 	REHEAT COILS

Reheat coils will be provided at each of the Landlord provided individual zones (total of 5)
as required to maintain space temperature.

	 	E.	 	CONTROLS

The controls system is to be DDC and shall be tied into the existing DDC front end controls
system currently used in the building. There will be individual temperature control for each
zone (no humidity control has been provided). System shall have trending capability.

	 	F.	 	AIR CHANGES

Air change rates will be 15 AC/HR for all Holding Rooms, Procedure Rooms, Quarantine Room,
Cagewash Room (or as required by the equipment’s heat load) and Gowning Vestibule. Air change
rates for Receiving, Feed & Bedding Rooms, Corridor and toilet Room will be at 15 AC/HR.

- F-3 -

 

	 	G.	 	PRESSURIZATION

All zones shall be equipped with manual volume dampers that shall be locked into position for
balance and pressurization.

	 	H.	 	CENTRAL PLANT

All CHW and HHW services will be provided by existing chillers, cooling towers, boilers and
associated pumps through new piping utilities.

	 	I.	 	CAGEWASH ROOM

The ceiling mounted exhaust distribution serving the Cagewash Room is to be of stainless steel
composition and shall have Stainless steel ducting from the grilles back to the main duct.

	 	J.	 	EXHAUST

The Holding Rooms shall have galvanized low wall exhaust ductwork, grilles and filters. Point
of use exhaust for necropsy tables. Duct work to be engineered and fabricated for future
carbon filter.

	 	K.	 	GENERAL UTILITIES

All ductwork shall be galvanized for both supply and exhaust air systems (except as noted
above). All mechanical piping utilities are to be either black iron or hard drawn copper (no
additional filtration it to be provided for any of the vivarium areas; air handling unit has
95% filters).

	5.	 	PLUMBING (VIVARIUM)

	 	A.	 	HOLDING ROOMS

Provide vacuum service to each bio-safety cabinet. (Floor drains or feed watering system shall
not be provided).

	 	B.	 	PROCEDURE ROOMS

Provide single bowl stainless steel sinks, with industrial H&C water faucets, and individual
eye wash stations O2 and CO2 piping to the fixtures as indicated on the plan.

	 	C.	 	CAGEWASH

Currently serving the other tenant. Industrial cold & hot water to be utilized at the scullery
sink and a single floor sink is to be installed Floor drain in room, Janitors sink to be
provided. New water heater (gas fired). Recessed hose bib for wash down. (Steam, if required
will be provided by the Tenant.)

- F-4 -

 

	 	D.	 	Toilet Room

(1) water closet and (1) lavatory for small toilet room with industrial H&C water faucet.

	 	E.	 	QUARANTINE ROOM

Wall mount sink with industrial H&C water faucet.

	 	F.	 	GOWNING/VESTIBULE

No plumbing services required.

	 	G.	 	FEED BEDDING & STORAGE

No plumbing services required.

	 	H.	 	CORRIDOR

No plumbing services required.

	 	I.	 	Vivarium Receiving

O2 and CO2 piping as indicated.

	6.	 	ELECTRICAL

1. All holding and procedure rooms to have occupancy sensors which will control a red light
outside of each respective room

2. Each room to have “ring and string” for future data

3. Provide egress lighting per code

4. 2 level lighting control system with central timer and override for rooms: 241, 246, 245
and 249.

5. Room 240 vivarium reception area

	 	a.	 	2 receptacles
	 
	 	b.	 	A & B switching only

6. Room 241 Quarantine

	 	a.	 	3 receptacles

- F-5 -

 

7. Room 242 glass washing dirty

	 	a.	 	1 receptacle
	 
	 	b.	 	Power as required to dumping station

8. Room 244 cagewash clean/cage storage

	 	a.	 	1 receptacle GF1
	 
	 	b.	 	Power as required to autoclave
	 
	 	c.	 	Power as required to washer
	 
	 	d.	 	Power as required to bottle filler

9. Room 245 Rat Holding

	 	a.	 	1 receptacle GFI

10. Room 246 Holding Area

	 	a.	 	6 receptacle GFI

11. Room 247 Rat Procedure

	 	a.	 	1 receptacle GFI
	 
	 	b.	 	Power at bench top for miscellaneous equipment
	 
	 	c.	 	Power as required to down draft table

12. Room 248 Mice Procedure

	 	a.	 	1 receptacle GFI
	 
	 	b.	 	Power at bench top for miscellaneous equipment
	 
	 	c.	 	Power as required to down draft table

13. Room 249

	 	a.	 	1 receptacle GFI

14. Power distribution

15. Room 250 tech vestibule

	 	a.	 	A & B Switching only
	 
	 	b.	 	2 receptacles

- F-6 -

 

	 	c.	 	Receptacles to tech desks

16. Toilets

	 	a.	 	1 receptacle
	 
	 	b.	 	one bathroom light fixture with local switch

17. Connections to mechanical equipment

18. General — Landlord to provide power and connections to the following equipment in the
vivarium as shown on Exhibit F, including:

	 	a.	 	Micro-isolators
	 
	 	b.	 	Biosafety cabinets
	 
	 	c.	 	Animal changing stations
	 
	 	d.	 	Refrigerator
	 
	 	e.	 	Cagewash, Autoclave
	 
	 	f.	 	Down draft tables
	 
	 	g.	 	Dumping station
	 
	 	h.	 	Bottle filler

CLARIFICATION:

With exception of vestibule and toilet areas all lighting in the vivarium shall be Class 10000.

EXCLUSIONS:

All low voltage systems and low voltage conduit.

Telephone/data and security (except for allowance provided as part of lab/office spec)

Anything not specifically listed above.

Handling, removal or disposal of any hazardous material is specifically excluded and any direct or
indirect costs incurred due to abatement or delay caused by abatement schedules shall be considered
to be outside the scope.

	7.	 	FIRE PROTECTION

	 	A.	 	ALARM PANEL

- F-7 -

 

1. Tie into existing fire alarm control panel per code.

2. Full-recessed gasketed sprinkler heads with chrome or white escutcheons throughout.

3. Cover plates on wall-mounted strobes shall be in accordance with Applicable Law.

4. Fire extinguisher cabinets shall be semi-recessed white or brushed 626 finish.

5. CA code minimum fire, life, safety system will be provided.

	8.	 	EXCLUSIONS

1. Surgery Lights;

2. The sixth and final zone and associated reheat coils serving Mice Holding (249), will be
paid for by the Tenant;

3. Lighting Control System, beyond what is specified;

4. Microisolators;

5. Changing Stations;

6. Bio-Safety Cabinets and thimble connections;

7. Animal Feed Water System, both loop and final connections;

8. Fiberglass reinforcement-in walls and ceilings;

9. Hepa Filtration;

10. Necropsy Tables;

11. Fold down tables for computer stations;

12. Air Shower;

13. Humidity Control;

14. Lockers/Shoe Storage;

15. Pass through to cell culture;

16. Micro isolator exhaust connections below ceiling;

17. Trench drains;

- F-8 -

 

18. Plant steam systems;

19. Lockers, Casework, etc., other than specified;

20. Animal Cages;

21, Cage Washer and all other equipment;

22. Glass washer and all other equipment;

23. Autoclave and all other equipment.

- F-9 -

 

Exhibit “G” — Standards for Exit Assessment 

The following minimum studies and assessments to be conducted in accordance with the applicable
portions of ASTM Standards E-1527-93 and E-1528-93 for Phase I Environmental Assessments as may be
changed by applicable authority, subject to follow-up testing if warranted by the following:

A. The following assessments and inspections:

1. “Interior and Exterior Site Assessment” consisting of a visual inspection of all surfaces
(including, without limitation, floors, walls, ceiling tiles, benches, sinks, interior
cabinets, exterior areas, and fume hoods) for signs of contamination and deterioration. Visual
inspection of all bench and hood sinks and readily accessible drain lines for signs of
deterioration, loss of integrity and leakage. The Interior and Exterior Site Assessment shall
include detailed written documentation of all observations and dated photos to document the
existing condition thereof.

2. Visual Inspection of Wastewater Collection System piping exclusively serving the Premises
for any breaks in or degradation of such piping systems, or any accumulated Hazardous
Materials.

3. Assessment of biological waste storage unit and any hazardous or radioactive waste storage
units, including governmental disclosures and decontamination certificates relating to the
same.

4. In order to verify that there is no contamination of the laboratory hoods and exhaust
system, an inspection shall be made consisting of an inspection of the laboratory hoods and
exhaust system with detailed documentation of all observances, including without limitation,
observed solids, liquids, odors or Hazardous Materials entrapment. Such inspection shall
include inspection of the roof area to determine the existence of any deterioration from
condensation of hazardous Materials produced by Tenant in the exhaust system which causes such
deterioration.

B. The Assessment Criteria shall also include such sampling and testing as the consultant
reasonably recommends based upon his or her observations, including post-cleanup sampling to verify
absence of Hazardous Materials.

- G-1 -

 

EXHIBIT B

SUBLEASED PREMISES

[MAP]

 

 

EXHIBIT C

FF&E

[To Be Inserted]

-3-

 

EXHIBIT D

CONSENT TO SUBLEASE AGREEMENT

(5871 Oberlin Drive)

     This CONSENT TO SUBLEASE AGREEMENT (this “Agreement”) is made as of June 29, 2009, by and
among VPI OBERLIN I, L.P., a California limited partnership (“Landlord”) and PHENOMIX CORPORATION,
a Delaware corporation (“Tenant”) and ANADYS PHARMACEUTICALS, INC., a Delaware corporation
(“Subtenant”).

R
E C I T A L S :

     A. Reference is hereby made to that certain Lease dated July 31, 2003, between Landlord and
Tenant (the “Lease”), for space on the ground floor (the “Premises”) in that certain office
building located at 5871 Oberlin Drive, San Diego, California 92121 (the “Building”).

     B. Pursuant to the terms of Article 21 of the Lease, Tenant has requested Landlord’s consent
to that certain Sublease dated June 18, 2009, between Tenant and Subtenant (the “Sublease”), with
respect to a subletting by Subtenant of a portion of the Premises, as more particularly described
in the Sublease (the “Sublet Premises”). A copy of the Sublease is attached hereto as Exhibit A.
Landlord is willing to consent to the Sublease on the terms and conditions contained herein.

     C. All defined terms not otherwise expressly defined herein shall have the respective meanings
given in the Lease.

A G R E E M E N T :

     1. Landlord’s Consent. Landlord hereby consents to the Sublease; provided, however,
notwithstanding anything contained in the Sublease to the contrary, such consent is granted by
Landlord only upon the terms and conditions set forth in this Agreement. The Sublease is subject
and subordinate to the Lease. Except as expressly provided herein, neither this Agreement nor the
Sublease shall be construed to modify, waive or amend any of the terms, covenants and conditions of
the Lease or to waive any breach thereof or any of Landlord’s rights or remedies thereunder or to
enlarge or increase any obligations of Landlord under the Lease. Landlord shall not be bound by
any of the terms, covenants, conditions, provisions or agreements of the Sublease. However,
Landlord agrees to the modified insurance provisions in Section 7.10 of the Sublease as to
Subtenant only.

     2. Non-Release of Tenant; Further Transfers. Neither the Sublease nor this consent
thereto shall release or discharge Tenant from any liability, whether past, present or future,
under the Lease or alter the primary liability of the Tenant to pay the rent and perform and comply
with all of the obligations of Tenant to be performed under the Lease (including the payment of all
bills rendered by Landlord for charges incurred by the Subtenant for services and materials
supplied to the Sublet Premises). Neither the Sublease nor this consent thereto shall be construed
as a waiver of Landlord’s right to consent to any further subletting either by Tenant or by the
Subtenant or to any assignment by Tenant of the Lease or assignment by the Subtenant of the
Sublease, or as a consent to any portion of the Sublet Premises being used or occupied by any other
party. Landlord may consent to subsequent sublettings and assignments of the Lease or the Sublease
or any amendments or modifications thereto without notifying Tenant nor anyone else liable under
the Lease and without obtaining their consent. No such action by Landlord shall relieve such
persons from any liability to Landlord or otherwise with regard to the Sublet Premises.

     3. Relationship with Landlord. Tenant hereby assigns and transfers to Landlord the
Tenant’s interest in the Sublease and all rentals and income arising therefrom, subject to the
terms of this Section 3. Landlord, by consenting to the Sublease agrees that until a default shall
occur in the performance of Tenant’s obligations under the Lease, Tenant may receive, collect and
enjoy the rents accruing under the Sublease. In the event Tenant shall default in the

 

 

performance of its obligations to Landlord under the Lease (whether or not Landlord terminates
the Lease), however, Landlord may, at its option, by giving notice to Tenant, either (i) terminate
the Sublease, (ii) elect to receive and collect, directly from Subtenant, all rent any other sums
owing and to be owed under the Sublease, as further set forth in Section 3.1, below, and/or (iii)
elect to succeed to Tenant’s interest in the Sublease, and cause Subtenant to attorn to Landlord,
as further set forth in Section 3.2, below. If Landlord elects to terminate the Sublease pursuant
to section 3(i) above, Subtenant acknowledges and agrees that Landlord shall have no liability to
Subtenant as a result thereof.

          3.1 Landlord’s Election to Receive Rents. Landlord shall not, by reason of the
Sublease, nor by reason of the collection of rents or any other sums from the Subtenant pursuant to
Section 3(ii), above, be deemed liable to Subtenant for any failure of Tenant to perform and comply
with any obligation of Tenant, and Tenant hereby irrevocably authorizes and directs Subtenant, upon
receipt of any written notice from Landlord stating that a default exists in the performance of
Tenant’s obligations under the Lease, to pay to Landlord the rents and any other sums due and to
become due under the Sublease. Tenant agrees that Subtenant shall have the right to rely upon any
such statement and request from Landlord, and that Subtenant shall pay any such rents and any other
sums to Landlord without any obligation or right to inquire as to whether such default exists and
notwithstanding any notice from or claim from Tenant to the contrary. Tenant shall not have any
right or claim against Subtenant for any such rents or any other sums so paid by Subtenant to
Landlord. Landlord shall credit Tenant with any rent received by Landlord under such assignment
but the acceptance of any payment on account of rent from the Subtenant as the result of any such
default shall in no manner whatsoever be deemed an attornment by the Landlord to Subtenant or by
Subtenant to Landlord, be deemed a waiver by Landlord of any provision of the Lease or serve to
release Tenant from any liability under the terms, covenants, conditions, provisions or agreements
under the Lease. Notwithstanding the foregoing, any payment of rent from the Subtenant directly to
Landlord, regardless of the circumstances or reasons therefor, shall in no manner whatsoever be
deemed an attornment by the Subtenant to Landlord in the absence of a specific written agreement
signed by Landlord to such an effect.

          3.2 Landlord’s Election of Tenant’s Attornment. In the event Landlord elects, at its
option, to cause Subtenant to attorn to Landlord pursuant to Section 3(iii), above, Landlord shall
undertake the obligations of Tenant under the Sublease from the time of the exercise of the option,
but Landlord shall not (i) be liable for any prepayment of more than one (1) month’s rent or any
security deposit paid by Subtenant to Tenant, (ii) be liable for any previous act or omission of
Tenant under the Sublease or for any other defaults of Tenant under the Sublease, (iii) be subject
to any defenses or offsets previously accrued which Subtenant may have against Tenant, or (iv) be
bound by any changes or modifications made to the Sublease without the written consent of Landlord.
In no event shall any such attornment increase the obligations or liability of Subtenant beyond
that which is contained in the Sublease and Subtenant will not be responsible for any defaults by
Tenant under the Lease.

          3.3 Roof Top Access. Subject to the term and conditions of the Lease, Landlord agrees
to allow Subtenant and Tenant access to the roof of the Building at no additional charge for the
purpose of performing maintenance and repairs to that certain dedicated HVAC unit currently
serving, as of the date hereof, the computer room portion of the Premises and/or Sublet Premises
and that certain boiler currently serving, as of the date hereof, the dish wash/autoclave room
within the Premises and/or Sublet Premises. Tenant and Subtenant each hereby agrees to indemnify,
defend, protect and hold Landlord harmless from and against any loss, cost, damage, liability,
expense, claim, action or cause of action of any third party, whether, foreseeable or not,
resulting as a direct or indirect consequence of the exercise by Tenant or Subtenant of its rights
under this Section 3.3 or the use of the roof of the Building. Tenant and/or Subtenant shall retain
Landlord’s designated roofing contractor to make any necessary penetrations and associated repairs
to the roof in order to preserve Landlord’s roof warranty.

     4. General Provisions.

          4.1 Consideration for Sublease. Tenant and Subtenant represent and warrant that there
are no additional payments of rent or any other consideration of any type payable by Subtenant to
Tenant with regard to the Sublet Premises other than as disclosed in the Sublease.

-4-

 

          4.2 Brokerage Commission. Tenant and Subtenant covenant and agree that under no
circumstances shall Landlord be liable for any brokerage commission or other charge or expense in
connection with the Sublease and Tenant agrees to protect, defend, indemnify and hold Landlord
harmless from the same and from any cost or expense (including, but not limited to, attorney’s
fees) incurred by Landlord in resisting any claim for any such brokerage commission.

          4.3 Controlling Law. The terms and provisions of this Agreement shall be construed in
accordance with and governed by the laws of the State of California.

          4.4 Binding Effect. This Agreement shall be binding upon and inure to the benefit of
the parties hereto, their heirs, successors and assigns. As used herein, the singular number
includes the plural and the masculine gender includes the feminine and neuter.

          4.5 Captions. The paragraph captions utilized herein are in no way intended to
interpret or limit the terms and conditions hereof; rather, they are intended for purposes of
convenience only.

          4.6 Partial Invalidity. If any term, provision or condition contained in this
Agreement shall, to any extent, be invalid or unenforceable, the remainder of this Agreement, or
the application of such term, provision or condition to persons or circumstances other than those
with respect to which it is invalid or unenforceable, shall not be affected thereby, and each and
every other term, provision and condition of this Agreement shall be valid and enforceable to the
fullest extent possible permitted by law.

          4.7 Attorney’s Fees. If any party commences litigation against another for the
specific performance of this Agreement, for damages for the breach hereof or otherwise for
enforcement of any remedy hereunder, the parties hereto agree to and hereby do waive any right to a
trial by jury and, in the event of any such commencement of litigation, the prevailing party shall
be entitled to recover from the other party such costs and reasonable attorneys’ fees as may have
been incurred.

          4.8 Landlord’s Costs. Within thirty (30) days after written request by Landlord,
Tenant shall pay to Landlord any costs and reasonable attorneys’ fees incurred by Landlord in
connection with Landlord’s review and analysis of the Sublease and preparation of this Consent to
Sublease.

     IN WITNESS WHEREOF, the parties have executed this Consent to Sublease Agreement as of the day
and year first above written.

	 	 	 	 	 	 	 
	 	 	“Landlord:”	 	 
	 
	 	 	 	 	 	 
	 	 	VPI OBERLIN I, L.P.,	 	 
	 	 	a California limited partnership	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Daniel J. Ryan	 	 
	 

	 	 	 	 	 	 
	 

	 	Its:	 	President	 	 
	 
	 	 	 	 	 	 
	 	 	“Tenant:”	 	 
	 
	 	 	 	 	 	 
	 	 	PHENOMIX CORPORATION,	 	 
	 	 	a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Laura Shawver	 	 
	 

	 	 	 	 	 	 
	 

	 	Its:
	 	Chief Executive Officer	 	 

[Signatures Continue on Following Page]

-5-

 

	 	 	 	 	 	 	 
	 	 	“Subtenant:”	 	 
	 
	 	 	 	 	 	 
	 	 	ANADYS PHARMACEUTICALS, INC.,	 	 
	 	 	a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Stephen T. Worland	 	 
	 

	 	 	 	 	 	 
	 

	 	Its:
	 	Chief Executive Officer	 	 

-6-

 

EXHIBIT “A”

[Sublease between Anadys Pharmaceuticals, Inc. and Phenomix Corporation]

-1-exv10w25

EXHIBIT 10.25

June 2nd, 2009

James T. Glover, CPA

c/o Anadys Pharmaceuticals, Inc.

3115 Merryfield Row,

San Diego, CA 92121

Re:      Severance Agreement and General Release

Dear Jim:

As we discussed, in connection with the Anadys Pharmaceuticals, Inc. (the “Company”) restructuring
and reduction in force, your employment with the Company will terminate on June 30th,
2009 (“Separation Date”). This letter will set forth our proposed agreement concerning your
separation from the Company, severance benefits from the Company and your release of the Company
from any obligations or claims after the Separation Date.

     1. You currently hold the position of Senior Vice President, Operations and Chief Financial
Officer. As of July 1, 2009, your responsibilities will cease, and all payments and benefits from
the Company will cease, except as provided in this letter Agreement (the “Agreement”).

     2. On your Separation Date, the Company shall provide you with a final paycheck through the
Separation Date which will include accrued and unused vacation pay, less all applicable federal,
state and local income, social security and other payroll taxes consistent with the Company’s
regular employment practices.

          (a) Pursuant to the Amended and Restated Severance and Change in Control Agreement by and
between you and the Company dated March 3, 2008 (the “Severance Agreement”) and contingent upon
satisfaction of the conditions described in the Severance Agreement, you are eligible for
Separation Benefits as defined under the Severance Agreement in exchange for your release of the
Company from all claims which you may have against the Company as of the Separation Date. A copy of
the Severance Agreement is attached to this Agreement as Attachment 1, and is incorporated by
reference herein.

     3. Within 14 days of the Separation Date you will be provided with election forms for medical
insurance continuation as provided by the Consolidated Omnibus Budget Reconciliation Act (COBRA).

     4. On the Separation Date, you will deliver to a Company representative, at a location to be
determined, all Company property which you have in your possession, including all equipment

 

 

Page 2 Tuesday June 2nd, 2009

and accessories, office equipment, account lists or contact lists, credit cards, keys, and
documents, including copies of documents.

     5. If you continue to fulfill your job responsibilities through the Separation Date, and in
exchange for your agreement to the release terms set forth in Paragraph 6 of this Agreement, on the
date eight (8) days from your signature on this Agreement, or if the 8th day falls on a
weekend or a holiday, on the next business day, Anadys will provide the following considerations:
1) provide a partial acceleration of vesting applicable to all of your outstanding stock options
so that the options that otherwise would vest through December 31, 2009 immediately will be vested;
and 2) provide an amendment to your stock option agreements, such that all of your vested stock
options (including those accelerated pursuant to the foregoing clause) will be exercisable until
December 31, 2010 (subject to your formal separate agreement to this modification and potential
loss of ISO status). This offer expires as of 5:00 p.m., July 27th, 2009.

     6. Except for claims under the Workers’ Compensation Act and Unemployment Insurance, in
consideration for the separation benefits described in the Severance Agreement and the additional
benefits set out in Paragraph 5 above, you release and forever discharge the Company, its present
and former agents, employees, officers, directors, shareholders, principals, predecessors, alter
egos, partners, parents, subsidiaries, affiliates, attorneys, insurers, successors and assigns,
from any and all claims (excluding indemnification obligations and rights under the Company’s
director and officer insurance policies), demands, grievances, causes of action or suit of any kind
arising out of, or in any way connected with, the dealings between the parties to date, including
the employment relationship and its termination.

     This general release includes, but is not limited to: (1) all claims arising out of or in any
way related to your employment with the Company or the termination of that employment; (2) all
claims related to your compensation or benefits from the Company, including, but not limited to,
salary, bonuses, commissions, vacation pay, expense reimbursements, severance pay, fringe benefits,
stock, stock options, or any other ownership interests in the Company; (3) all claims for breach of
contract, wrongful termination, and breach of the implied covenant of good faith and fair dealing;
(4) all tort claims, including, but not limited to, claims for fraud, defamation, emotional
distress, and discharge in violation of public policy; and (5) all federal, state or administrative
claims, rule, regulation, or ordinance, including, but not limited to, claims arising under Title
VII of the Civil Rights Act of 1964, the Americans with Disabilities Act, the California Fair
Employment and Housing Act, or the Age Discrimination in Employment Act of 1967, as amended
(“ADEA”), and the Older Workers Benefit Protection Act, as amended (“OWBPA”) (except a claim
relating to whether this release or waiver is valid under the ADEA and except for any claims under
the ADEA that may arise after the date this agreement is executed by you). By executing this
Agreement, you acknowledge and agree that with the payments described in this Agreement, you have
received all compensation to which you are entitled from the Company through the Separation Date,
plus consideration in excess of that amount.

 

 

Page 3 Tuesday June 2nd, 2009

     7. You acknowledge that with this document you have been advised in writing to consult with an
attorney prior to executing this waiver of ADEA claims and that you have been given at least
forty-five (45) days from the date of this Agreement in which to consider entering into the waiver
of the ADEA claims, if any. If you decide to sign before July 27th, 2009 you
acknowledge that you are doing so knowingly and voluntarily. In addition, you acknowledge that you
have been informed that you may revoke a signed waiver of the ADEA claims for up to 7 days after
executing this agreement. To be effective, your revocation must be in writing, signed, dated and
delivered to Mary Glanville at Anadys Pharmaceuticals, Inc. no later than 7 days from the date on
which you sign this agreement. If the 7th day falls on a weekend or holiday, your
revocation must be delivered the next business day. You also acknowledge that you have been
provided a detailed list of the job titles and ages of all employees who were terminated in this
group termination and the ages of all employees in the same job classification or organizational
unit who were not terminated.

     8. By executing this agreement, you acknowledge that you have read the document and have had
the opportunity to receive independent legal advice with respect to executing this agreement and
that you expressly waive the rights and benefits you otherwise might have under California Civil
Code Section 1542, which provides:

A general release does not extend to claims which the
[employee] does not know or suspect to exist in his favor
at the time of executing the release, which if known by him
must have materially affected his settlement with the
[company].

          In other words, there may be additional facts or claims which you do not know about on the
date you sign this Agreement. By signing this Agreement, you understand and agree that you are
giving up your right to bring any known or unknown claim against the Company.

     9. The Company expressly denies liability of any kind to you, and nothing contained in this
agreement will be construed as an admission of any liability.

     10. You acknowledge and agree that you have a continuing obligation to keep confidential and
not to disclose information known or learned as a consequence of your employment with the Company,
including facts relating to the business operations, procedures, research strategies and
approaches, finances, product candidates, development plans and strategies, suppliers, and business
tactics, plans and strategies and other information which is not generally known in the industry.
You also agree that you have a continuing obligation under the terms of the Proprietary Information
and Inventions Agreement which you signed on September 25th, 2006, and that the relevant
terms of that agreement will continue in full force and effect.

     11. Nothing in this Agreement alters the at-will nature of your employment. Anadys is an
at-will employer and as such your employment continues to be voluntarily and for no specified
period. As a result, you are free to resign or the company may terminate your employment at any
time, for any reason, with or without cause. No employee of Anadys can enter into an

 

 

Page 4 Tuesday June 2nd, 2009

employment
contract for a specified period of time, or make any agreement contrary to the at-will policy
of Anadys without the written approval of the Chief Executive Officer of Anadys.

     12. This Agreement has been executed and delivered within California, and our respective
rights and obligations shall be construed and enforced in accordance with and governed by
California law.

     13. You acknowledge that this Agreement and the Severance Agreement is the entire agreement
between the parties regarding severance benefits and/or compensation and supersedes all prior and
contemporaneous oral and written agreements and discussions. This agreement may be amended only by
an agreement in writing.

     14. Any dispute or claim arising out of this Agreement will be subject to final and binding
arbitration. The arbitration will be conducted by one arbitrator who is a member of the American
Arbitration Association (AAA) and will be governed by the Model Employment Arbitration rules of
AAA. The arbitration will be held in San Diego, California and the arbitrator will apply
California substantive law in all respects. The arbitrator shall have all authority to determine
the arbitrability of any claim and enter a final, binding judgment at the conclusion of any
proceedings. Any final judgment only may be appealed on the grounds of improper bias or improper
conduct of the arbitrator.

 

 

Page 5 Tuesday June 2nd, 2009

We trust that the severance benefits and other consideration set out in this Agreement will assist
you in the smooth transition of your employment. This offer expires on July 27th, 2009
at 5 pm. We wish you the best in your future endeavors.

Sincerely yours,

Anadys Pharmaceuticals, Inc.

	 	 	 
	/s/ Stephen T. Worland
	 	 
	 

By: Stephen T. Worland, Ph.D.

	 	 

I understand, acknowledge and agree to the terms and conditions, including the releases and
waivers, set forth in this letter agreement.

	 	 	 	 	 
	DATED: 6/30/09
 

To be signed between June 30th, 2009 and July 27th, 2009
in order to be eligible for severance benefits

	 	/s/ James T. Glover
 

James T. Glover, CPA

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