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Exhibit 10.5    
    

SUBLEASE  

        1.    PARTIES.    This Sublease, dated March 11, 2002, is made by Corgentech, Inc. ("Sublessor") and
successor to Caber Corporation, and Michael J. Gurfinkel ("Sublessee"). 

        2.    MASTER LEASE.    Sublessor is the lessee under a written lease dated March 31, 2000, wherein Gateway
Center, L.L.C. ("Lessor") leased to Sublessor the real property located in the City of S. San Francisco, County of San Mateo, State of California, described as ("Master Premises"). Said lease
has been amended by the following amendments: said lease and amendments are herein collectively referred to as the "Master Lease" and are attached hereto as Exhibit "A." 

        3.    PREMISES.    Sublessor hereby subleases to Sublessee on the terms and conditions set forth in this Sublease the
following portion of the Master Premises ("Premises"): Approximately 3,060 rentable square feet of space located on the fourth (4th) floor of the Building and commonly known as Suite
460, as further set forth in Exhibit A to the Office Lease. 

        4.    WARRANTY BY SUBLESSOR.    Sublessor warrants and represents to Sublessee that the Master Lease has not been
amended or modified except as expressly set forth herein, that Sublessor is not now, and as of the commencement of the Term hereof will not be, in default or breach of any of the provisions of the
Master Lease, and that Sublessor has no knowledge of any claim by Lessor that Sublessor is in default or breach of any of the provisions of the Master Lease. 

        5.    TERM.    The term of this Sublease shall commence on April 1, 2002 ("Commencement Date"), or when Lessor
consents to this Sublease (if such consent is required under the Master Lease), whichever shall last occur, and end on March 31, 2005 ("Termination Date"), unless otherwise sooner terminated in
accordance with the provisions of this Sublease. In the event the Term commences on a date other than the Commencement Date, Sublessor and Sublessee shall execute a memorandum setting forth the actual
date of commencement of the Term. Possession of the Premises ("Possession") shall be delivered to Sublessee on the commencement of the Term. If for any reason Sublessor does not deliver Possession to
Sublessee on the commencement of the Term, Sublessor shall not be subject to any liability for such failure, the Termination Date shall not be extended by the delay, and the validity of this Sublease
shall not be impaired, but rent shall abate until delivery of Possession. Notwithstanding the foregoing, if Sublessor has not delivered Possession to Sublessee within thirty (30) days after the
Commencement Date, then at any time thereafter and before delivery of Possession, Sublessee may give written notice to Sublessor of Sublessee's intention to cancel this Sublease. Said notice shall set
forth an effective date for such cancellation which shall be at least ten (10) days after delivery of said notice to Sublessor. If Sublessor delivers Possession to Sublessee on or before such
effective date, this Sublease shall remain in full force and effect. If Sublessor fails to deliver Possession to Sublessee on or before such effective date, this Sublease shall be cancelled, in which
case all consideration previously paid by Sublessee to Sublessor on account of this Sublease shall be returned to Sublessee, this Sublease shall thereafter be of no further force or effect, and
Sublessor shall have no further liability to Sublessee on account of such delay or cancellation. If Sublessor permits Sublessee to take Possession prior to the commencement of the Term, such early
Possession shall not advance the Termination Date and shall be subject to the provisions of this Sublease, including without limitation the payment of rent. 

        6.    RENT.    

        6.1    Minimum Rent.    Sublessee shall pay to Sublessor as minimum rent, without deduction,
setoff, notice, or demand, at 1651 Page Mill Road, Palo Alto, CA 94304, or at such other place as Sublessor shall designate from time to time by notice to Sublessee. Sublessee shall pay to Sublessor
upon 

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execution
of this Sublease the sum of Five Thousand Three Hundred Fifty-Five Dollars ($5,355.00) as rent for the fourth month of the term. If the Term begins or ends on a day other than
the first or last day of a month, the rent for the partial months shall be prorated on a per diem basis. Additional provisions: Please find below the rent schedule for the term of the sublease.
Sublessee shall pay the sums as shown below in advance on the first day of each month of the Term. 

	Months
 
	 	Square Foot Rate
	 	Total Base Rent

	1-3	 	$	0.00	 	$	0.00
	4-12	 	$	1.75	 	$	5,355.00
	13-24	 	$	2.00	 	$	6,120.00
	25-37	 	$	2.25	 	$	6,885.00

        7.    SECURITY DEPOSIT.    Sublessee shall deposit with Sublessor upon execution of this Sublease the sum of Five
Thousand Three Hundred Fifty-Five Dollars ($5,355.00) as security for Sublessee's faithful performance of Sublessee's obligations hereunder ("Security Deposit"). If Sublessee fails to pay
rent or other charges when due under this Sublease, or fails to perform any of its other obligations hereunder, Sublessor may use or apply all or any portion of the Security Deposit for the payment of
any rent or other amount then due hereunder and unpaid, for the payment of any other sum for which Sublessor may become obligated by reason of Sublessee's default or breach, or for any loss or damage
sustained by Sublessor as a result of Sublessee's default or breach. If Sublessor so uses any portion of the Security Deposit, Sublessee shall, within ten (10) days after written demand by
Sublessor, restore the Security Deposit to the full amount originally deposited, and Sublessee's failure to do so shall constitute a default under this Sublease. Sublessor shall not be required to
keep the Security Deposit separate from its general accounts, and shall have no obligation or liability for payment of interest on the Security Deposit. In the event Sublessor assigns its interest in
this Sublease, Sublessor shall deliver to its assignee so much of the Security Deposit as is then held by Sublessor. Within ten (10) days after the Term has expired, or Sublessee has vacated
the Premises, or any final adjustment pursuant to Subsection 6.2 hereof has been made, whichever shall last occur, and provided Sublessee is not then in default of any of its obligations hereunder,
the Security Deposit, or so much thereof as had not theretofore been applied by Sublessor, shall be returned to Sublessee or to the last assignee, if any, of Sublessee's interest hereunder. 

        8.    USE OF PREMISES.    The Premises shall be used and occupied only for Uses permitted in Article 5 of the
Master Lease document and for no other use or purpose. 

        9.    ASSIGNMENT AND SUBLETTING.    Sublessee shall not assign this Sublease or further sublet all or part of the
premises without the prior written consent of Sublessor (and the consent of Lessor, if such is required under the terms of the Master Lease). 

        10.    OTHER PROVISIONS OF SUBLEASE.    All applicable terms and conditions of the Master Lease are incorporated into
and made a part of this Sublease as if Sublessor were the lessor thereunder, Sublessee the lessee thereunder, and the Premises the Master Premises,  except for the following: 

Sublessee
assumes and agrees to perform the lessee's obligations under the Master Lease during the Term to the extent that such obligations are applicable to the Premises, except that the obligation
to pay rent to Lessor under the Master Lease shall be considered performed by Sublessee to the extent and in the amount rent is paid to Sublessor in accordance with Section 6 of this Sublease.
Sublessee shall not commit or suffer any act or omission that will violate any of the provisions of the Master Lease. Sublessor shall exercise due diligence in attempting to cause Lessor to perform
its obligations under the Master Lease for the benefit of Sublessee. If the Master Lease terminates, this Sublease shall terminate and the parties shall be relieved of any further liability or
obligation under this Sublease; provided, however, that if the Master Lease 

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terminates
as a result of a default or breach by Sublessor of Sublessee under this Sublease and/or the Master Lease, then the defaulting party shall be liable to the nondefaulting party for the damage
suffered as a result of such termination. Notwithstanding the foregoing, if the Master Lease gives Sublessor any right to terminate the Master Lease in the event of the partial or total damage,
destruction or condemnation of the Master Premises or the building or project of which the Master Premises are a part, the exercise of such right by Sublessor shall not constitute a default or breach
hereunder. 

        11.    ATTORNEYS' FEES.    If Sublessor, Sublessee or Broker shall commence an action against the other arising out of
or in connection with this Sublease, the prevailing party shall be entitled to recover its costs of suit and reasonable attorney's fees. 

        12.    AGENCY DISCLOSURE.    Sublessor and Sublessee each warrant that they have dealt with no other real estate
broker in connection with this transaction except BT COMMERCIAL REAL ESTATE, who represents both Sublessor and Sublessee. 

        In
the event that BT COMMERCIAL REAL ESTATE represents both Sublessor and Sublessee, Sublessor and Sublessee hereby confirm that they were timely advised of the dual representation and
that they consent to the same and that they do not expect said broker to disclose to either of them the confidential information of the other party. 

        13.    COMMISSION.    Upon execution of this Sublease, and consent thereto by Lessor (if such consent is required
under the terms of the Master Lease), Sublessor shall pay Broker a real estate brokerage commission in accordance with Sublessor's contract with Broker for the subleasing of the Premises, if any, and
otherwise in the amount of Fifteen Thousand Five Hundred and Sixty and 10/100 Dollars ($15,560.10), for services rendered in effecting this Sublease. Broker is hereby made a third party beneficiary of
this Sublease for the purpose of enforcing its right to said commission. 

        14.    NOTICES.    All notices and demands which may or are to be required or permitted to be given by either party on
the other hereunder shall be in writing. All notices and demands by the Sublessor to Sublessee shall be sent by United States Mail, postage prepaid, addressed to the Sublessee at the Premises, and to
the address hereinbelow, or to such other place as Sublessee may from time to time designate in a notice to the Sublessor. All notices and demands by the Sublessee to Sublessor shall be sent by United
States Mail, postage prepaid, addressed to the Sublessor at the address set forth herein, and to such other person or place as the Sublessor may from time to time designate in a notice to the
Sublessee. 

To
Sublessor: 

Mr. Richard
Powers

1651 Page Mill Road

Palo Alto, CA 94304 

To
Sublessee: 

The
Law Offices of Michael J. Gurfinkel

601 Gateway Boulevard

Suite #460

S. San Francisco, CA 

        15.    CONSENT BY LESSOR.    THIS SUBLEASE SHALL BE OF NO FORCE OR EFFECT UNLESS CONSENTED TO BY LESSOR WITHIN 10 DAYS
AFTER EXECUTION HEREOF, IF SUCH CONSENT IS REQUIRED UNDER THE TERMS OF THE MASTER LEASE. 

        16.    COMPLIANCE.    The parties hereto agree to comply with all applicable federal, state and local laws,
regulations, codes, ordinances and administrative orders having jurisdiction over the parties, 

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property
or the subject matter of this Agreement, including, but not limited to, the 1964 Civil Rights Act and all amendments thereto, the Foreign Investment in Real Property Tax Act, the
Comprehensive Environmental Response Compensation and Liability Act and the Americans with Disabilities Act. 

        17.    See Addendum re: furniture.    

	Sublessor: /s/ Richard P. Powers	 	Sublessee: /s/ Michael J. Gurfinkel
	

By:	

Richard P. Powers
	
 	

By:	

Michael J. Gurfinkel

	

Title:	

Vice President and Chief Financial Officer
	
 	

Title:	

Owner

	

Date:	

3/11/02
	
 	

Date:	

3/18/02

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Exhibit 10.6    
    

SUBLEASE AGREEMENT  

        THIS
SUBLEASE AGREEMENT (this "Sublease") is entered into by and between COULTER PHARMACEUTICAL, INC., a Delaware corporation ("Sublessor"), and CORGENTECH, INC., a
Delaware corporation ("Sublessee"), as of May 15, 2003. Sublessor and Sublessee hereby agree as follows: 

        1.    DEFINED TERMS.    The following terms shall have the following meanings: 

Additional Rent has the meaning set forth in Section 6(b) of this Sublease. 

Base Rent means the following monthly base rental rates: 

	PERIOD
 
	 	MONTHLY BASE RENT
	 
	Month 1	 	 	0	 
	Month 2	 	$	21,224	*
	Months 3-12	 	$	91,224	*
	Months 13-24	 	$	115,360	 
	Months 25-Expiration Date	 	$	149,714	 

	*
	subject
to adjustment pursuant to Section 6(d)

Building means the office building located at 650 Gateway Boulevard, South San Francisco, California. 

Commencement Date means the later to occur of (i) the date on which this Sublease has been approved in writing by Landlord,
(ii) July 1, 2003, (iii) the date Landlord has completed the Floor Repair (defined in the Consent to Sublease) and (iv) the date Sublessor has delivered possession of the
Premises to Sublessee in the condition required hereunder, including, without limitation, satisfaction of the Sublessor Obligations listed on Exhibit D attached hereto and made a part hereof. 

Consent to Sublease has the meaning set forth in Section 4(a) of this Sublease. 

Environmental Laws has the meaning set forth in the Lease. 

Expiration Date means June 30, 2006, or such earlier date as this Sublease may be terminated in accordance with the terms hereof. 

FF&E has the meaning set forth in Section 3(a) of this Sublease. 

First Extension Term has the meaning set forth in Section 10(a) of this Sublease. 

Floor Repair has the meaning set forth in the Consent to Sublease. 

Floor Reports has the meaning set forth in Section 3(c) of this Sublease. 

Hazardous Materials has the meaning set forth in Section 32(b) of the Lease. 

Initial Term means the period of time beginning on the Commencement Date and ending on the Expiration Date, subject to Subject
9(a) of this Sublease. 

Issuer has the meaning set forth in Section 7(b) of this Sublease. 

Landlord means Gateway Boulevard Associates LLC, a California limited liability company, and its successors and assigns. 

Landlord's Address means c/o The Raiser Organization, 800 South Claremont Street, Suite 201, San Mateo, California 94402, Attn: Phillip H. Raiser. 

 

Lease means that certain Lease Agreement dated November 7, 1997, between HMS Gateway Office, L.P., a Delaware limited partnership, the
predecessor-in-interest of Landlord, as landlord, and Sublessor, as tenant; as amended by that certain First Amendment to Lease Agreement dated as of November 10, 1998;
that certain Second Amendment to Lease Agreement dated
as of May 19, 2000; and that certain Amended and Restated Agreement Concerning Assignment and Sublease Profits dated as of May 23, 2002. Sublessor hereby represents and warrants that a
true, correct and complete copy of the Lease is attached hereto as Exhibit A. 

Letter of Credit has the meaning set forth in Section 7(b) of this Sublease. 

Permitted Transfer has the meaning set forth in Section 11(b). 

Permitted Uses means all uses permitted under the Lease, subject to Section 8 of this Sublease. 

Premises means that portion of the premises demised to Sublessor under the Lease consisting of approximately fifty thousand four hundred (50,400) square
feet constituting the entire Building, as depicted on Exhibit B. 

Pro Rata Share means the percentage obtained by dividing the rentable square footage subleased by Sublessee by the corresponding rentable square footage
of the Building and the Project, as set forth in the Lease. Based upon the rentable square footage of the Premises, the Building and the Project, as of the Commencement Date, Sublessee's Pro Rata
Share of the Building will be 100% and Sublessee's Pro Rata Share of the Project will be 33.33% 

Project means the project containing approximately 7.5 acres of land commonly known as Lot 2B of the Gateway Center and referred to as the Gateway
Technology Center, together with the land and improvements on which the Project is situated and all common areas. 

Project Services has the meaning set forth in Section 5(e). 

Renewal Notice has the meaning set forth in Section 10(a) of this Sublease. 

Second Extension Term has the meaning set forth in Section 10(b) of this Sublease. 

Second Renewal Notice has the meaning set forth in Section 10(b) of this Sublease. 

Security Deposit has the meaning set forth in Section 7(a) of this Sublease. 

Siemens BMS has the meaning set forth in Section 5(f). 

Sublessee means Corgentech, Inc., a Delaware corporation. 

Sublessee's Address means, (i) prior to the Commencement Date, Corgentech, Inc., 1651 Page Mill Road, Palo Alto, CA
94304-1209, Attn: Chief Financial Officer and (ii) on and after the Commencement Date, Corgentech, Inc., 650 Gateway Boulevard, South San Francisco, CA
94080-7014, Attn: Chief Financial Officer. For any notices sent to Sublessee, copies shall be provided to Cooley Godward LLP, 5 Palo Alto Square, 3000 El Camino Real, Palo
Alto, CA 94306, Attn: Toni Wise, Esq. 

Sublessee's Property has the meaning set forth in Section 19 of this Sublease. 

Sublessor means Coulter Pharmaceutical, Inc., a Delaware corporation. 

Sublessor's Address means 1124 Columbia, Suite 200, Seattle, WA 98104. 

Sublessor Obligations has the meaning set forth in Exhibit D. 

Term has the meaning set forth in Section 9 of this Sublease. 

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        2.    SUBLEASE.    Sublessor hereby subleases to Sublessee, and Sublessee hereby subleases from Sublessor, the
Premises for the Term, upon all of the terms, covenants and conditions contained herein. 

        3.    CONDITION OF PREMISES.    

        (a)    Sublessor Removal of Personal Property.    Sublessor agrees that prior to the Commencement Date, Sublessor
shall remove, or cause to be removed, from the Premises all of Sublessor's personal property, except the furniture, equipment, appliances, work stations, cubicles and cabling located within the
Premises as of December 12, 2002, as such personal property is described on Exhibit C attached hereto (the "FF&E"), and the lab and
related equipment currently located in the Premises. Sublessee shall be entitled to use the FF&E pursuant to a separate agreement between Sublessor and Sublessee, to be entered into concurrently with
the execution of this Sublease (the "FF&E Agreement"). Sublessee shall also have the right to use the lab and related equipment which shall remain within the Premises throughout the Term, except to
the extent removed as a part of the Approved Alterations or any subsequent alterations made by Sublessee pursuant to the terms of this Sublease. Sublessor acknowledges that part of the Floor Repair to
be performed by Landlord involves removal and reinstallation of portions of the FF&E as well as the lab and related equipment. Sublessee shall have the right to confirm that all of the FF&E and the
lab and related equipment are replaced, and Sublessor shall restore and replace any of the FF&E and lab and related equipment which is not properly installed or returned upon the completion of the
Floor Repair in the condition required under this Sublease. 

        (b)    "As is" Condition of Premises; Alterations.    Except for the Sublessor Obligations as set forth on  Exhibit D to this
Sublease or as otherwise set forth in this Sublease, Sublessee shall accept possession of the Premises in their present "as is"
condition, without representation or warranty as to their condition or suitability for Sublessee's intended use, and with no obligation on the part of Sublessor to make any alterations or
modifications to the Premises or any area outside the Premises for the benefit of Sublessee. Notwithstanding anything to the contrary contained in this Sublease, Sublessor warrants that:
(i) all improvements in the Premises constructed by Sublessor were constructed in accordance with all laws, ordinances and regulations then applicable thereto, (ii) Sublessor has not
released, discharged or disposed of Hazardous Materials on, in, at or under the Premises which Hazardous Materials have not been cleaned up, removed or remediated in compliance with Environmental
Laws, and (iii) to Sublessor's knowledge, all Building systems, including, but not limited to HVAC, electrical, plumbing and waste systems, are in good working order. Any alterations or
improvements desired by Sublessee shall be made by Sublessee at its sole cost and expense. Plans and specifications for Sublessee's alterations and improvements shall be subject to the prior written
approval of Landlord and Sublessor as provided in the Lease and herein; provided, however, that Sublessor acknowledges that it has preliminarily approved the alterations and improvements described on  Exhibit E attached hereto and shown on the drawings attached as Exhibit E-1
hereto (collectively, the "Approved Alterations"), subject only to its right to review and approve Sublessee's final plans and specifications for such alterations and improvements, which approval
Sublessor shall not unreasonably withhold, delay or condition. Alterations or improvements to the Premises required by any and all applicable laws shall be made by Sublessee, and the cost thereof
shall be prorated between Sublessor and Sublessee based upon the length of their respective term under either the Master Lease or the Sublease, as applicable, provided that Sublessee shall pay 100% of
the cost of any such required alterations or improvements if Sublessee's specific use of the Premises trigger the requirement that such alterations or improvements be made. Sublessee shall, at
Sublessee's sole cost and expense, comply promptly with all applicable statutes, ordinances, rules, regulations, orders, restrictions of record, and requirements in effect during the Term or any part
of the Term hereof regulating the use by Sublessee of the Premises; provided, however, that with respect to any capital improvements required as a result of any of the foregoing, the costs of such
capital improvements shall be prorated between Sublessor and Sublessee based upon their respective term under either the 

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Master
Lease or this Sublease, as applicable. Sublessor shall reimburse any prorated sums owed by Sublessor under this Section 3(b) within thirty
(30) days of written demand therefor. Upon termination of this Sublease, Sublessee shall be responsible for the cost of removing any alterations which were installed for or by Sublessee in the
Premises, except that Sublessee shall not be required to remove (i) any alterations if under the applicable provisions of the Lease such alterations may remain in the Premises upon the
termination of the Lease or (ii) any Approved Alterations to the extent Landlord has confirmed in the Consent to Sublease that they need not be removed. Notwithstanding anything to the contrary
contained in this Section 3(b), if Sublessor delivers to Sublessee written notice at least six (6) months before the Expiration Date,
Sublessor may require that (i) any of Sublessee's modifications and improvements to any laboratory areas on the first floor be restored to their condition as of the date hereof, which
restoration would include, without limitation, the removal of the vivarium and the replacement of two to three fume hoods from laboratories 3026, 3028, 3032 and 3034, and (ii) the high density
storage racks installed as of the date hereof in the library be replaced. 

        (c)    Floor Condition.    Sublessor and Landlord have disclosed to Sublessee that there has been some water
penetration of the concrete slab on the ground floor of the Premises as disclosed in the report by Marx Okubo dated April 1, 2003. Related to the water penetration is the presence of mold
within the
Building, as disclosed in the Mold Inspection Report dated April 16, 2003 prepared by Meca Consulting, Inc. ("Meca") for Sublessee. Meca has also prepared for Sublessee that certain
Microbiological (Mold) Hazard Abatement Plan Revised May 13, 2003, that certain Mold Remediation Report dated April 29, 2003, that certain Mold Inspection Report—Phase II
dated April 29, 2003, and a floor plan entitled Mold Hazard Remediation. In addition, Exponent Failure Analysis Associates prepared for Sublessee a report dated April 24, 2003 regarding
the observed moisture on the ground floor of the Premises. The Marx Okubo report, the Mold Inspection Report, the Microbiological (Mold) Hazard Abatement Plan, the Mold Remediation Report, the Mold
Inspection Report—Phase II, the Mold Hazard Remediation floor plan and the Exponent Failure Analysis Associates report referred to in this  Section 3(c) are collectively referred to herein as
the "Floor Reports". Pursuant to the Consent to Sublease, Landlord shall perform the Floor
Repair (as defined in the Consent to Sublease) to the reasonable satisfaction of Sublessee. Sublessee shall have the right to conduct additional testing in the proposed vivarium and tissue culture
areas of the Premises and "reasonable satisfaction of Sublessee" as used in the immediately preceding sentence shall include any additional remediation required to address Sublessee's particular use
and protocol within such areas. Notwithstanding anything to the contrary in Section 3(b) above or elsewhere in this Sublease or the Lease,
Sublessee shall have no responsibility for the repair or remediation of any water penetration of the ground floor or any condition relating thereto, including, without limitation, any mold condition
which currently exists or may arise, or the cost or expense thereof. In the event that at any time during the term of this Sublease further repairs or remediation of the floor or any other portions of
the Building are required and the repair or remediation of any such condition (i) requires the removal of any alterations or improvements constructed by Sublessee on the Premises pursuant to
the terms of this Sublease, Sublessor shall pay for the cost of the removal and replacement of such alterations or improvements, or (ii) renders any portion of the Premises untenantable, the
Base Rent hereunder shall be equitably abated in proportion to the portion of the Premises so rendered untenantable. 

        4.    CONDITIONS.    

        (a)   Concurrently
with the execution of this Sublease, Sublessor, Sublessee and Landlord shall enter into that certain Consent to Sublease ("Consent to Sublease") wherein
Landlord shall provide its written consent to this Sublease. This Sublease is conditioned upon the delivery to Sublessor and Sublessee of a fully executed original of this Sublease and Consent to
Sublease. 

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        (b)   It
is a condition precedent to Sublessee's obligations under this Sublease that Landlord shall have entered into the Consent to Sublease. In the event the condition
expressed in this Section 4 is not satisfied within three (3) business days following the delivery to Landlord of a copy hereof executed
by Sublessee and Sublessor, then upon three (3) business days prior written notice, Sublessor or Sublessee may terminate this Sublease by giving written notice of termination to the other party
at any time prior to the satisfaction of such condition. In the event this Sublease is terminated due to the nonsatisfaction of the foregoing condition, neither Sublessor nor Sublessee shall have any
further rights or obligations hereunder. Sublessee and Sublessor each agrees to supply information and/or execute and acknowledge further documents in connection with this Sublease which are
reasonably required by Landlord in connection with Landlord's review of this Sublease and the satisfaction of the condition expressed in this  Section 4. 

        5.    PROVISIONS CONSTITUTING SUBLEASE.    

        (a)    Relationship Between Sublessee and Landlord.    This Sublease is subject to all of the terms and conditions of
the Lease. Sublessee hereby assumes and agrees to perform the obligations of Sublessor as Tenant under the Lease to the extent such terms and conditions are applicable to the Premises subleased
pursuant to this Sublease. Sublessee shall not commit or permit to be committed on the Premises any act or omission which shall violate any term, covenant or condition of the Lease. 

        (b)    Relationship Between Sublessee and Sublessor.    Except as otherwise provided herein, all of the terms and
conditions contained in the Lease are incorporated herein as terms and conditions of this Sublease with each reference therein to "Landlord," "Tenant," the "Lease" and the "Premises," being deemed to
refer to Sublessor, Sublessee, this Sublease, and the Premises, respectively), except in the following provisions of the Lease, the term "Landlord" shall continue to mean Landlord and not Sublessor:
the third paragraph of 2, 4(b) (with respect to expenses of Landlord), 4(c), 13(b), 14, 20, 21, 22, 29, 42 and 47(b). Notwithstanding the foregoing, the following provisions of the Lease are not
incorporated into this Sublease: Basic Lease Information (except Permitted Use definition), the second paragraph of 2, 3, 4(a), 4(d), 4(e), 7, 8(b), 8(c), 8(d), 10, 11, 38, 39, 40, 49, 50, 51, 52 and
53, and Exhibits A, B, C, D, G, H, I, J; First Amendment Sections 2, 3, 4, 5, 6, 7, 8 11 and Exhibit A-FA (except Section D.3 to the extent Landlord grants rights to
Sublessee thereunder pursuant to the Consent to Sublease); Second Amendment and Amended and Restated Agreement Concerning Assignment and Sublease Profits. Notwithstanding anything to the contrary
contained herein, with respect to any specific obligation in the Lease required to be performed by Landlord, to the extent Landlord has performed such obligation Sublessor shall not be required to do
so. 

        (c)    Notices.    All notices or demands of any kind required or desired to be given by Sublessor or Sublessee to the
other hereunder shall be in writing and shall be deemed delivered upon receipt if sent by United States mail, certified postage prepaid, return receipt requested, or by private overnight courier,
addressed to the Sublessor or Sublessee respectively at the addresses set forth in Section 1, or at such other addresses as the parties may
specify by notice in accordance with this section. All rent and other payments due under this Sublease shall be made by Sublessee to Sublessor at the same address. Sublessor and Sublessee shall each
deliver to the other a copy of every notice received from Landlord affecting or relating to the Premises, or affecting or relating to the rights and/or obligations hereunder or under the Lease, within
five (5) days following receipt thereof. Notwithstanding anything to the contrary contained in this Sublease, the time limits specified in the Lease for the giving of notice, making of demands,
performing any act, condition or covenant (including cure of any breach) or the exercise of any right, remedy or option, are hereby decreased or increased for purposes of this Sublease, by shortening
or lengthening the same, as the case may be, in each instance by three (3) days, when necessary to 

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enable
Sublessor to give notice, make demands, perform any act, correct any failure, or otherwise to secure compliance and perform under the Lease in a timely manner. 

        (d)    Services.    Notwithstanding Section 5(b) hereof,
Sublessor shall have no obligation to provide any of the services to be provided by Landlord under the Lease and Sublessor's sole obligation with respect thereto shall be to use commercially
reasonable efforts to obtain Landlord's compliance with the Lease upon Sublessee's written request. To the extent permitted by law and by Landlord, Sublessee shall have the right to request all
services directly from Landlord at Sublessee's sole cost and expense. Sublessee shall promptly notify Sublessor in writing of all such requests for services. Such efforts shall include, without
limitation, upon Sublessee's request (a) promptly notifying Landlord of its non-performance under the Lease and requesting that Landlord perform its obligations under the Lease
and/or (b) assigning Sublessor's rights under the Lease to Sublessee to the extent necessary to permit Sublessee to institute legal proceedings against Landlord to obtain the performance of
Landlord's obligations under the Lease; provided, however, that if Sublessee commences a lawsuit or other action, Sublessee shall (i) pay all costs and expenses in connection therewith, and
(ii) indemnify Sublessor against, and hold Sublessor harmless from, all costs, liabilities, damages and/or expenses, including, without limitation, reasonable attorneys fees, incurred by
Sublessor in connection therewith, recognizing that the Lease covers premises in excess of the Premises and that an action against Landlord pursuant to this Section may cause damages to other portions
of the premises covered by the Lease. 

        (e)    Services by Sublessor; Security System.    Notwithstanding any other provision of this Sublease to the
contrary, Sublessor shall provide facilities management and maintenance of the nitrogen system and emergency power generator to cause the same to be in good condition and repair, and at adequate
levels for Sublessee's use (collectively, "Project Services"). Sublessor shall provide copies of any available maintenance contracts or reports for the Project Services to Sublessee within ten
(10) days of demand at Sublessee's sole cost and expense. Sublessee shall pay its pro rata share of the cost of any Project Services, including personnel costs associated therewith; provided,
however, that Sublessor shall equitably adjust such allocations if Sublessor reasonably determines that any particular subtenant of the Project is disproportionately utilizing Project Services. As of
the Commencement Date, Sublessee shall pay 100% of the costs relating to the provision of nitrogen (which costs shall be adjusted if any other tenants of the Project take occupancy) and 33.3% of the
costs associated with the emergency power generator. Sublessee shall operate and maintain the existing security system for the Building and shall be permitted to upgrade or reasonably modify such
system, all at the sole cost and expense of Sublessee. 

        (f)    HVAC System.    Sublessee shall have the right to segregate the existing Siemens building management control
system to cause the Premises to have its own separate, yet equal system ("Siemens BMS"). Specifically, Sublessee shall have the right to include in the Siemens BMS for the Premises, without
limitation, the same level of graphics, screen controls and Reno alarm out calling as the existing system for the 600 Building. Sublessor shall reimburse Sublessee as a tenant improvement allowance,
Sublessee's actual cost of so segregating the Siemens BMS up to maximum amount of Twenty Five Thousand Dollars ($25,000) within ten (10) days of demand for such reimbursement, which demand
shall be accompanied by reasonable supporting documentation of such costs. 

        (g)    Consents.    In any circumstance where the Lease requires that Landlord's approval or consent be obtained,
Sublessee shall be required to obtain the written approval or consent of Sublessor as well. Where the Lease specifies that Landlord shall not unreasonably withhold its approval or consent, Sublessor
shall not unreasonably withhold, condition or delay its approval or consent as well. In addition, Sublessor shall not unreasonably withhold, condition or delay its approval or consent with respect to:
final plans and specifications for the Approved Alterations and assignment or subletting pursuant to Section 11 of this Sublease. 

6

 

        (h)    Signage.    Subject to the Landlord's consent, Sublessee shall have the right to install and utilize such
signage as approved by Landlord, provided that all costs for production, installation and maintenance of such signage shall be borne solely by Sublessee and at the end of the Term such signage shall
be removed in accordance with the same standards set forth for the 600 building under the Lease. 

        (i)    Parking.    Subject to the provisions of the Lease, Sublessee shall have the right to use one hundred fifty
(150) non-exclusive and undesignated parking spaces in the Project's parking areas. 

        6.    RENT.    

        (a)    Base Rent.    Sublessee shall pay to Sublessor an amount equal to the monthly installment of Base Rent for the
third full month of the Term (Ninety-One Thousand Two Hundred Twenty-Four Dollars ($91,224.00)) upon execution of this Sublease. Commencing on the Commencement Date, Sublessee
shall pay Base Rent to Sublessor as rent for the Premises, in monthly installments in advance, and thereafter on the first day of each calendar month of the Term, without deduction, offset, prior
notice or demand, in lawful money of the United States, in the amounts shown with respect to the applicable period on the chart contained in  Section 1, which amounts reflect Sublessee's entitlement
to one (1) month's free Base Rent with respect to the first thirty
(30) days following the Commencement Date, and a rental abatement of Base Rent equal to Seventy Thousand Dollars ($70,000.00) with respect to the second thirty (30) days following the
Commencement Date. The abatements of the first and second month's Base Rent, as provided in the foregoing sentence, do not affect Sublessee's obligation to pay Additional Rent with respect to the
first and second months of the Term. If the first day for which the monthly installment of Base Rent is payable is not the first day of a calendar month, or if the last day of the Term is not the last
day of a calendar month, the monthly installment of Base Rent shall be prorated for the fractional month(s). In the case of a proration at the beginning of the Term, Sublessee shall pay the proration
for such partial month upon the due date for Base Rent for the second month of the Term; provided, however, that nothing herein shall in any way limit Sublessee's right to a total of $70,000 of rental
abatement, as reflected in the Month 2 Monthly Base Rent Amount shown in Section 1. Sublessee shall pay the proration for the last month of the
Term when Base Rent for such month is due. 

        (b)    Additional Rent.    Sublessee acknowledges that Sublessor is obligated to pay to Landlord all amounts provided
for in Section 4(b) of the Lease ("Additional Rent"). Sublessee agrees to pay to Sublessor as Additional Rent hereunder (i) its Pro Rata Share of all such Additional Rent charged to
Sublessor by Landlord under the Lease, and (ii) any other costs and expenses incurred by Sublessor under the Lease, as a result of or arising out of Sublessee's use and occupancy of the
Premises, including, without limitation Sublessor's share of costs of Project Services or otherwise. Sublessee shall pay such Additional Rent in accordance with the time for payment set forth in the
Lease. 

        (c)    Late Charge.    The parties hereby expressly agree that in the event Sublessee shall fail to make payment of
any installment of Base Rent or any other sums due hereunder within five (5) days of the date that such amounts are due, the provisions of Paragraph 6 of the Lease shall apply. 

        (d)    Rental Abatement.    Notwithstanding any provision of this Sublease to the contrary, if Landlord has not
completed the Floor Repair by June 1, 2003, then in addition to all of Sublessee's other rights hereunder, Sublessee shall be entitled to a day-for-day abatement of Base
Rent until the Floor Repair is completed, which rental abatement shall be calculated at $3,040.80 per day. By way of example, if the Floor Repair is not completed until June 15, 2003, then the
Base Rent for July, 2003, as the first month of the Term, shall be $0; the Base Rent for August, 2003 shall be reduced to $0 (resulting from the application of a portion of the $45,612 credit for 

7

 

15 days
of rental abatement accruing to Sublessee pursuant to this Section 6(d) against the Base Rent payable with respect to the second
month of the Term, leaving a credit balance of $24,388); and the Base Rent for September, 2003 shall be reduced to $66,836 (resulting from the application of the $24,388 credit balance to the Base
Rent payable with respect to the third month of the Term). For purposes of determining Sublessee's entitlement to abatement of Base Rent under this  Section 6(d), "completion" of the Floor Repair
shall not include the installation of sheet vinyl flooring in labs 3022 and 3024, the timing of
which is affected by the completion of certain work by Sublessee, as described in the Consent to Sublease. 

        7.    SECURITY DEPOSIT.    

        (a)   To
secure the faithful performance by Sublessee of all the covenants, conditions and agreements in this Sublease on the part of Sublessee to be fulfilled, kept, observed
and performed including, but not by way of limitation, such covenants and agreements in this Sublease which become applicable upon the termination of the same by re-entry or otherwise,
Sublessee shall deposit with Sublessor, with five (5) days of execution of this Sublease, a security deposit in the amount of Four Hundred Fifty Thousand Dollars ($450,000.00) (the "Security
Deposit"). The Security Deposit shall be in the form of the Letter of Credit, as described in Section 7(b) below. Sublessor and Sublessee agree
that: (a) the Security Deposit or any portion thereof may be applied to the curing of any default that may then exist, without prejudice to any other remedy or remedies which Sublessor may have
on account thereof, and upon such application Sublessee shall pay or provide an additional letter of credit otherwise satisfying the terms of this Sublease to Sublessor within five (5) days of
demand the amount so applied which shall be added to the Security Deposit so the same may be restored to its original
amount; (b) should the Lease be assigned by Sublessor, the Security Deposit or any portion thereof not previously applied shall be assigned to Sublessor's assignee, and upon such assignee's
express assumption of Sublessor's obligations under this Sublease, Sublessee shall release Sublessor from any and all liability with respect to the Security Deposit and/or its application or return;
(c) the sum deposited or the portion thereof not previously applied, or the original Letter of Credit, as applicable, shall be returned to Sublessee without interest within thirty
(30) days following the expiration of the Term of this Sublease, except to the extent reasonably required to cure any breach by Sublessee of any of its obligations hereunder and provided that
Sublessee has vacated the Premises and surrendered possession thereof to Sublessor at the expiration of the Term; (d) in the event that Sublessor terminates this Sublease or Sublessee's right
to possession by reason of an event of default under this Sublease by Sublessee, Sublessor may apply the Security Deposit against damages suffered to the date of such termination and/or may retain the
Security Deposit to apply against such damages as may be suffered or shall accrue thereafter by reason of Sublessee's default; and (e) in the event any bankruptcy, insolvency, reorganization or
other creditor-debtor proceedings shall be instituted by or against Sublessee, or its successors or assigns, the Security Deposit shall be deemed to be applied first to the payment of any Rent due
Sublessor for all periods prior to the institution of such proceedings, and the balance, if any, of the Security Deposit may be retained or paid to Sublessor in partial liquidation of Sublessor's
damages. 

        (b)   The
letter of credit supplied by Sublessee as the Security Deposit shall be an irrevocable, unconditional, standby letter of credit in a form substantially similar to
the form attached hereto as Exhibit F and incorporated herein (such letter of credit, together with any renewal or replacement letters of credit
delivered or to be delivered by Sublessee under this Section, shall be referred to herein collectively as the "Letter of Credit"). The Letter of Credit shall be issued by a national money center bank
mutually acceptable to Sublessor and Sublessee (the "Issuer"). The final form of the Letter of Credit and the form of any replacement Letter of Credit shall be acceptable to Sublessor in its
reasonable discretion. The Letter of Credit shall be for an initial term of not less than twelve (12) months and shall be maintained in force at all times from issuance through thirty
(30) days following the expiration or earlier termination of this Sublease. If Sublessee fails to 

8

 

deliver
to Sublessor either a replacement Letter of Credit or cash in the full amount of the Security Deposit required hereunder at least thirty (30) days prior to the expiration date of an
outstanding Letter of Credit, such failure shall be a default under this Sublease (without the requirement of notice) entitling Sublessor, in addition to its other remedies, to draw down all or part
of the current Letter of Credit and to then hold such cash proceeds as the Security Deposit in accordance with Section 7(a). Sublessor shall have
the right, upon a transfer or assignment of its rights as landlord under this Sublease and concurrent with the return of the original Letter of Credit, to require Sublessee to deliver a replacement
Letter of Credit designating Sublessor's successor as the beneficiary, at Sublessor's sole cost and expense. No draw under the Letter of Credit shall be deemed a waiver of, or be deemed to have cured,
any default by Sublessee under any provision of this Sublease except to the extent directly applied to cure such default(s). 

        8.    USE OF PREMISES.    Except as set forth herein and the Consent to Sublease, Sublessee shall use the Premises for
the Permitted Uses and for no other purpose without the prior written consent of Sublessor and, if required by the Lease, Landlord. Notwithstanding any other provision hereof, and subject to any
limitations in the Lease, Sublessee shall have access to the Premises on a seven day a
week, twenty four hour a day basis. Sublessee shall additionally have the right to use the vivarium to be installed or operated within the Premises without the prior written consent of Sublessor,
which Sublessee intends to construct as part of the Approved Alterations. Sublessee's use of a vivarium, shall be at all times (i) limited to small animals and (ii) in compliance with
applicable law. 

        9.    TERM.    

        (a)    Initial Term.    The Initial Term of this Sublease shall be for a period commencing on the Commencement Date
and ending on the Expiration Date, unless terminated sooner for any reason pursuant to this Sublease. It is an express condition to the occurrence of the Commencement Date that Sublessor shall have
performed the Sublessor Obligations set forth on Exhibit D to this Sublease and Landlord shall have completed the Floor Repair. Sublessor agrees
to use commercially reasonable efforts to stay apprised of the progress of the Floor Repair. Sublessor agrees to provide weekly progress updates regarding the Sublessor Obligations, and (to the extent
Sublessor has been furnished information by Landlord) of the Floor Repair, so that Sublessee may appropriately plan its facility requirements. Sublessor shall also periodically provide Sublessee with
an anticipated Commencement Date, updated as required to reflect the status of the Floor Repair and Sublessor Obligations. 

        (b)    Delay in Delivery.    Notwithstanding anything to the contrary contained herein, if (i) Landlord has not
completed all aspects of the Floor Repair except the installation of vinyl flooring in labs 3022 and 3024 by August 1, 2003, or (ii) if Sublessor does not deliver the Premises with the
Sublessor Obligations completed by July 1, 2003, then Sublessee shall have the right to terminate this Sublease by written notice to Sublessor given within five (5) days after such date.
In addition to the foregoing, in the event that Sublessee has not elected to terminate this Sublease under any of the foregoing conditions and the Floor Repair has not been completed by
October 31, 2003, either Sublessor or Sublessee may terminate this Sublease by written notice to the other party within five (5) days after such date. Upon receipt of such notice,
Sublessor shall return any sums previously paid or deposited by Sublessee and this Sublease shall thereafter terminate and be of no further force or effect. 

        (c)    Early Occupancy.    Sublessee shall have a right of early occupancy to the Premises upon the mutual execution
of this Sublease and the Consent to Sublease for purposes of installing its furniture, cabling and equipment and the Approved Alterations in order to ready the Premises for its tenancy, provided that
Sublessee shall not conduct any business operations in the Premises prior to the Commencement Date. Sublessee's early occupancy during such period shall be subject to all the terms and conditions of
this Sublease except that Sublessee shall have no obligation to pay Base Rent or Additional Rent on account thereof. During any early occupancy, Sublessee shall 

9

 

reasonably
coordinate its activities with any of Sublessor's or Landlord's repair or other work occurring within the Premises. 

        10.    OPTION TO EXTEND INITIAL TERM.    

        (a)    First Extension Term.    Subject to the terms and conditions of this  Section 10, Sublessee shall have the right to
extend the Initial Term of this Sublease for a one (1) year period from the Expiration Date
through May 31, 2007 (the "First Extension Term"). The First Extension Term, together with the Initial Term shall be referred to as the "Term" if: 

        (i)    Sublessor
receives notice of exercise ("Renewal Notice") not later than the date that is nine (9) months prior to the Expiration Date; 

        (ii)   Sublessee
is not in default under this Sublease beyond any applicable cure periods at the time that Sublessee delivers its Renewal Notice and at the commencement of the
First Extension Term; and 

        (iii)  This
Sublease has not been assigned by Sublessee and not more than seventy-five percent (75%) of the Premises has been further sublet by Sublessee prior to
the date upon which Sublessee delivers its Renewal Notice. 

        Base
Rent for the First Extension Term shall be One Hundred Fifty-Four Thousand Two Hundred Five and Sixty-Three One-Hundredths Dollars ($154,205.63) per month,
and shall be payable in addition to Additional Rent. Base Rent and Additional Rent for the First Extension Term shall be payable on the same terms as such items are payable under this Sublease during
the Initial Term. Promptly after Sublessee provides the Renewal Notice, the parties shall enter into an amendment to this Sublease to extend the Expiration Date to May 31, 2007 and set forth
the Base Rent as provided in this Section 10(a).

        (b)    Second Extension Term.    Subject to the terms and conditions of this  Section 10, Sublessee shall have the right to
extend the Term of this Sublease through the balance of the term of the Master Lease, which
expiration date Sublessor hereby represents is November 13, 2010 (the "Second Extension Term"). The Second Extension Term, together with the First Extension Term and Initial Term shall be
referred to as the "Term" if: 

        (i)    Sublessee
has exercised the right to extend the Initial Term for the First Extension Term pursuant to  Section 10(a); 

        (ii)   Sublessor
receives notice of exercise ("Second Renewal Notice") not later than the date that is nine (9) months prior to the Expiration Date as amended by  Section 10(a); 

        (iii)  Sublessee
is not in default under this Sublease beyond any applicable cure periods at the time that Sublessee delivers its Second Renewal Notice and at the
commencement of the Second Extension Term; and 

        (iv)  This
Sublease has not been assigned by Sublessee and not more than seventy-five percent (75%) of the Premises has been further sublet by Sublessee prior to
the date upon which Sublessee delivers its Second Renewal Notice. 

        Base
Rent during the first year of the Second Extension Term shall be the greater of (i) 103% of the Base Rent during the immediately preceding year or (ii) fair market
rent. Commencing on the first anniversary of the Second Extension Term, and annually thereafter, Base Rent shall be increased to equal 103% of the Base Rent during the immediately preceding year. Base
Rent and Additional Rent for the Second Extension Term shall be payable on the same terms as such items are payable under this Sublease during the Initial Term and First Extension Term. 

        For
purposes hereof, "fair market rent" shall mean the effective base rental rates (including periodic adjustments to such base rental rates) then being received for premises of similar
size and 

10

 

quality
to the Premises, located in industrial parks in the South San Francisco area which are similar in size and quality to the Project, leased for terms of approximately equal length to the Term,
and otherwise subject to leases containing substantially similar terms as those contained in this Sublease. Notwithstanding the foregoing, "fair market rent" shall not include any rental value
attributable to improvements, alterations, fixtures, equipment, and personal property installed in the Premises at Sublessee's expense. 

        Not
more than six months nor less than three months prior to the commencement of the Second Extension Term, Sublessor and Sublessee shall meet and attempt in good faith to determine and
mutually agree upon the Base Rent to be paid during the Second Extension Term pursuant to this Section 10(b). If, 60 days prior to the
commencement of the Second Extension Term, the parties have not reached agreement, each party shall appoint an Appraiser (hereinafter defined) and shall give notice to the other party of the identity
of the Appraiser no later than 50 days prior to the commencement of the Second Extension Term. For purposes hereof, "Appraiser" means a real estate broker or MAI designated appraiser, in either
case with not less than 5 years of full time commercial appraisal or brokerage experience in the South San Francisco area and with no prior business dealings with the party appointing such
Appraiser. 

        If
either party fails to timely appoint an Appraiser, the sole Appraiser appointed shall determine the Base Rent based on the criteria described above. If two Appraisers are appointed,
they shall immediately meet and attempt to agree upon such Base Rent. If they are unable to do so within 15 days after their first meeting, they shall jointly appoint a third Appraiser and the
third Appraiser shall make
such determination within 10 days of his/her appointment. If the two Appraisers are unable to agree upon such third Appraiser, either party may petition the Presiding Judge of the Superior
Court of the City and County of San Francisco to appoint such third Appraiser. 

        The
determination of Base Rent as provided herein shall be binding upon the parties hereto. Promptly upon such determination, the parties shall execute an amendment specifying the Base
Rent payable during the Second Extension Term and to extend the Expiration Date to November 13, 2010. 

        11.    ASSIGNMENT AND SUBLETTING.    

        (a)    Approval Required.    Sublessee's right to assign this Sublease or sublease the Premises shall be subject to
all of the terms and conditions of the Lease, except that Sublessee shall also obtain Sublessor's prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. 

        (b)    Bonus Rent.    In the event that Sublessor has consented to an assignment or subletting by Sublessee, Sublessor
shall be entitled to receive: (i) in the case of a subletting, fifty percent (50%) of all rent (however denominated and paid) payable by the sub-sublessee to Sublessee in excess of
that payable by Sublessee pursuant to the provisions of this Sublease, and (ii) in the case of an assignment, fifty percent (50%) of all rent (however denominated and paid) payable by the
assignee to Sublessee in excess of that payable by Sublessee pursuant to the provisions of this Sublease. For the purposes of this Section 11(b),
the term "rent" shall mean all consideration paid or given, which are not for a part of Sublessee's Property (as defined in Section 19), directly
or indirectly, for the use of the Premises or any portion thereof. In computing the amount payable to Sublessor, Sublessee may deduct from the rent and consideration all reasonable and customary
expenses directly incurred by Sublessee attributable to the assignment or sublease, including, but not limited to, brokerage fees, legal fees and any tenant improvements and any free rent or other
rent concessions made for the benefit of any subtenant. "Sublet" and "sublease" shall include a sublease as to which Sublessee is sublessor and any sub-sublease or other
sub-subtenancy, irrespective of the number of tenancies and tenancy levels between the ultimate occupant and Sublessor, as to which Sublessee receives any consideration, as defined in this
subsection. Any rent or other consideration which is to be passed through to Sublessor by Sublessee pursuant to this 

11

 

subsection
shall be paid to Sublessor within thirty (30) days after receipt by Sublessee and shall be paid in cash, irrespective of the form in which received by Sublessee from any
sub-subtenant or assignee. The provisions of this Section 11 shall not apply to any sublease to any entity which controls, is
controlled by, or is under common control with Sublessee; to any entity which results from a merger, reorganization of or consolidation with Sublessee; to any entity engaged in a joint venture with
Sublessee; or to any entity that acquires all or substantially all of the stock or assets of Sublessee as a going concern with respect to the business being conducted in the Premises (each, a
"Permitted Transfer"). Sublessor's consent shall not be required for any Permitted Transfer and Sublessor shall have no right to any sums or other economic consideration resulting from any Permitted
Transfer. 

        12.    DAMAGE AND DESTRUCTION.    In the event of damage or destruction to the Premises or the Building, each party
agrees to forward to the other, within twenty-four (24) hours of receipt, a copy of each notice received from, or given to, Landlord in connection therewith. If the Premises or the
Building are damaged or destroyed by fire or other casualty and Landlord undertakes to repair the same pursuant to the Lease, this Sublease shall remain in full force and effect subject to the terms
and conditions of the Lease, except that if the rent payable under the Lease is reduced as a result of such damage or destruction, Sublessee shall be entitled to a proportionate reduction of Base Rent
and Additional Rent payable hereunder while such repairs are being made. If the Premises or the Building are damaged to an extent that Landlord has a right to terminate the Lease, and Landlord in fact
terminates the Lease, this Sublease shall terminate. Except as provided in the Lease, Landlord and Sublessor shall not be required to repair any injury or damage by fire or other cause to the property
of Sublessee, or to make any repairs or replacements of any paneling, decoration, railings, floor coverings or any additions or improvements installed on the Premises by Sublessee. 

        13.    EMINENT DOMAIN.    If, due to any taking or appropriation of all or a part of the Premises or the Building,
Landlord exercises its right to terminate the Lease, this Sublease shall terminate. If part of the Premises shall be so taken or appropriated and this Sublease shall not be terminated as provided
herein, then the rent thereafter to be paid hereunder shall be equitably reduced, as provided in the Lease. 

        14.    HAZARDOUS MATERIALS.    Sublessee shall strictly comply with all covenants regarding Hazardous Materials
contained in the Lease, including without limitation, the following: 

        (a)   Sublessee
agrees that during its use and occupancy of the Premises it will (1) not (A) permit Hazardous Materials to be present on or about the Premises
except in a manner and quantity necessary for ordinary performance of Sublessee's business or (B) release, discharge or dispose of any Hazardous Materials on, in, at, under, or emanating from,
the Premises, the Building or the Project; (2) comply with all Environmental Laws relating to Sublessee's use of Hazardous Materials in, on or about the Premises and not engage or permit its
agents to engage in any activity in, on or about the Premises in violation of any Environmental Laws; and (3) immediately notify Sublessor of (A) any inquiry, test, investigation or
enforcement proceeding by any governmental agency or authority against Sublessee, Sublessor, Landlord or the Premises, Building or Project relating to any Hazardous Materials or under any
Environmental Laws or (B) the occurrence of any event or existence of any condition that would cause a breach of any of the covenants set forth in this  Section 14. 

        (b)   If
Sublessee's use of Hazardous Materials on or about the Premises results in a release, discharge or disposal of Hazardous Materials on, in, at, under or emanating
from, the Premises, the Building or the Project, Sublessee agrees to investigate, clean up, remove or remediate such Hazardous Materials in full compliance with (1) the requirements of
(A) all Environmental Laws and (B) any governmental agency or authority responsible for the enforcement of Environmental 

12

 

Laws;
and (2) any additional requirements of Landlord that are reasonably necessary to protect the value of the Premises, the Building or the Project. 

        (c)   Sublessee
shall surrender the Premises to Landlord upon the expiration or earlier termination of this Lease free of debris, waste or Hazardous Materials placed on, about
or near the Premises by Sublessee or Sublessee's agents, and in a condition that complies with (i) all Environmental Laws relating to Hazardous Materials placed on, about or near the Premises
by Sublessee or Sublessee's agents and (ii) any additional requirements of Landlord that are reasonably necessary to protect the value of the Premises, the Building or the Project, including,
without limitation, the obtaining of any closure permits or other governmental permits or approvals related to Sublessee's use of Hazardous Materials in or about the Premises. Sublessee's obligations
and liabilities pursuant to the provisions of this Section 14 shall survive the expiration or earlier termination of this Sublease. 

        Sublessor
hereby represents and warrants that Sublessor has complied with Section 32 of the Lease in all respects, and that in vacating the Premises for Sublessee's use and
occupancy, it has complied with all requirements of Section 32(h) of the Lease as if such vacation were a surrender of the Premises to Landlord. 

        15.    ENTRY BY SUBLESSOR.    Subject to the requirements of the Master Lease and any security measure of Sublessee,
Sublessor reserves and shall at any and all times (within ordinary business hours, except in the case of emergency) upon not less than 48 hours' notice have the right to enter the Premises to
inspect the same, to post notices of nonresponsibility, or (during the last nine (9) months of the Term) to show the Premises to prospective subtenants, or in the event of Sublessee's default
with respect thereto, to perform any obligation of Sublessor as Tenant under the Lease relating to the use, maintenance or repair of the Premises. In the event that Sublessee shall not provide
Sublessor with a key to the Premises, Sublessee waives any claims for damages resulting directly from Sublessor's use of force to enter the Premises in the event of an emergency. Sublessee waives any
claim for damages for any injury or inconvenience to or interference with Sublessee's business, any loss of occupancy or quiet enjoyment of the Premises, and any other loss occasioned by such entry,
except to the extent caused by the negligence of Sublessor, its agents or employees, provided that the entrance to the Premises shall not be blocked thereby and further provided that the business of
Sublessee shall not be interfered with unreasonably. Except in the case of emergency, Sublessor shall give Sublessee reasonable prior notice of any intended entry of the Premises by Sublessor, and
shall obtain the permission of an officer of Sublessee (which permission shall not be unreasonably withheld). Sublessee shall have the right to have a representative present during any entry into the
Premises. Any entry to the Premises by Sublessor pursuant to this Section 15 shall not under any circumstances be construed or deemed to be a
forcible or unlawful entry into or a detainer of the Premises or an eviction of Sublessee from the Premises or any portion thereof. 

        16.    INDEMNIFICATION.    

        (a)   Sublessee
shall hold Sublessor, and its subsidiaries, affiliates, directors, officers, agents, contractors, servants, employees and licensees (hereinafter "indemnitees")
harmless from and shall indemnify and defend indemnitees against any and all damages, claims or liability arising from (i) any breach or default in the performance of any obligation of
Sublessee hereunder, or (ii) any injury or damage to any person or property occurring in, on or about the Premises, except where indemnified by Sublessor under clause (ii) of  Section 16(b) below, and except, in the case of both clause (i) and (ii) above, to the extent such liability arises from the gross
negligence or willful misconduct of indemnitees or from the floor condition described in Section 3(c) or Landlord's performance of the Floor
Repair. 

        (b)   Sublessor
shall hold Sublessee, and its subsidiaries, affiliates, directors, officers, agents, contractors, servants, employees and licensees (hereinafter "indemnitees")
harmless from and shall 

13

 

indemnify
and defend indemnitees against any and all damages, claims or liability (i) arising from any breach or default in the performance of any obligation of Sublessor hereunder, and
(ii) for any injury or damage to any person or property occurring in, on or about the Building or any part thereof when such injury or damage shall be caused by the act, neglect, default, or
omission of any duty with respect to the same by Sublessor, its agents, employees or invitees, except to the extent such liability arises from the gross negligence or willful misconduct of
indemnitees; and from and against all costs, counsel fees, expenses and liabilities incurred in or in connection with any such claim or any action or proceeding brought thereon. 

        (c)   Sublessor
represents to Sublessee that the Lease is in full force and effect, and except with respect to the floor condition described in  Section 3(c) of this Sublease, that no default or event that, with
the passing of time or the giving of notice or both, would constitute a
default, exists on the part of Sublessor, or, to Sublessor's knowledge, Landlord. Sublessor agrees to use commercially reasonable efforts to maintain the Lease in full force and effect, except to the
extent that any failure to maintain the Lease is due to the failure of Sublessee to comply with any of its obligations under this Sublease or a failure by any other sublessee or assignee of Sublessor
to comply with its obligations under the applicable sublease or assignment. Sublessor shall not amend or modify the Lease in such a manner as to materially adversely affect Sublessee's use of the
Premises or increase the obligations or decrease the rights of Sublessee hereunder, without the prior written consent of Sublessee, which may be granted or withheld at Sublessee's sole discretion. 

        17.    BROKERS.    Sublessor and Sublessee each represents to the other that it has dealt with no brokers in
connection with this Sublease other Sublessor's broker, CB Richard Ellis/Kenmark Commercial, and Sublessee's broker, BT Commercial. Each of Sublessor and Sublessee shall indemnify, defend, and hold
the other harmless from and against any costs, expenses, liability, loss or damage arising out of or relating to the falsity of the foregoing representation. Sublessor agrees to pay all brokerage fees
and
commissions payable to BT Commercial with respect to this Sublease in accordance with the provisions of a separate commission contract. 

        18.    SURRENDER.    Sublessee agrees that on the last day of the Term, or on the sooner termination of this Sublease,
Sublessee shall surrender the Premises to Sublessor (i) in the same condition as received, normal wear and tear and damage from casualty excepted, and (ii) otherwise in accordance with
Paragraph 32(h) of the Lease. Normal wear and tear shall not include any damage or deterioration that would have been prevented by proper maintenance by Sublessee, or Sublessee otherwise
performing all of its obligations under this Sublease. On or before the expiration or sooner termination of this Sublease, Sublessee shall, in accordance with this  Section 18, and at Sublessee's
sole cost and expense, remove, and repair any damage cause by such removal, (A) all of Sublessee's Property
and Sublessee's signage from the Premises, the Building and the Project and (B) all tenant improvements and alterations required to be removed pursuant to  Section 3(b) of this Sublease. Any of
Sublessee's Property not so removed by Sublessee as required herein shall be deemed abandoned and may be
stored, removed, and disposed of by Sublessor at Sublessee's expense, and Sublessee waives all claims against Sublessor for any damages resulting from Sublessor's retention and disposition of such
property; provided, however, that Sublessee shall remain liable to Sublessor for all costs incurred in storing and disposing of such abandoned property of Sublessee. All Approved Alterations and other
alterations to the Premises except those which Sublessee is required to remove pursuant to Section 3(b) of this Sublease shall remain the
property of Sublessor or Landlord. If the Premises are not surrendered at the end of the Term or sooner termination of this Sublease, and in accordance with the provisions of this  Section 18 and
Paragraph 32(h) of the Lease, Sublessee shall indemnify, defend and hold Sublessor harmless from and against any and all
loss or liability resulting from delay by Sublessee in so surrendering the Premises including, without limitation, any loss or liability resulting from a claim made against Sublessor made by any
succeeding sublessee or prospective sublessee founded on or resulting from such delay and losses to Sublessor due to lost opportunities to sublease any portion of 

14

 

the
Premises to any such succeeding sublessee or prospective sublessee, together with, in each case, actual attorneys' fees and costs. 

        19.    LANDLORD WAIVER.    Sublessor waives any and all rights, title and interest Sublessor now has, or hereafter may
have, whether statutory or otherwise, to Sublessee's inventory, equipment (except Approved Alterations), furnishings, trade fixtures, books and records, personal property, accounts, goodwill,
intangible personal property associated with Sublessee's business, and Sublessee improvements paid for by Sublessee located at the Premises (singly and/or collectively, the "Sublessee's Property").
Sublessor acknowledges that Sublessor has no lien, right, claim, interest or title in or to the Sublessee's Property. Sublessor further agrees that Sublessee have the right, at its discretion, to
mortgage, pledge, hypothecate or grant a security interest in the Sublessee's Property as security for its obligations under any equipment lease or other financing arrangement related to the conduct
of Sublessee's business at the Premises. Sublessor further agrees to reasonably cooperate with Sublessee in connection with any such lease or financing arrangement by executing and delivering any
documentation reasonably required to be executed by Sublessor, and any real estate consent or waiver forms submitted by any vendors, equipment lessors, chattel mortgagees, or holders or owners of the
Sublessee's Property setting forth, inter-alia that Sublessor waives, in favor of such party any superior lien, claim, interest or other
right therein. The Sublessee's Property shall not become the property of Sublessor or Landlord or a part of the realty no matter how affixed to the Premises and may be removed by
Sublessee or any equipment lessors at any time and from time to time during the entire term of this Sublease. Sublessee shall promptly repair any damage caused by the removal of such property, whether
effected by Sublessee or any equipment lessors. 

        20.    SUBROGATION.    The waiver of subrogation provisions set forth in Section 17 of the Lease shall be
deemed a three-party agreement binding among and inuring to the benefit of Sublessee, Sublessor and Landlord, by reason of its consent to this Sublease. 

        21.    FF&E AGREEMENT.    Any default in payment by Sublessee within five (5) business days of written demand
therefor by Sublessor under the FF&E Agreement shall constitute a default under this Sublease. 

        22.    MISCELLANEOUS.    

        (a)    Entire Agreement.    This Sublease, together with its Exhibits, constitutes the entire agreement of Sublessor
and Sublessee with respect to the matters described herein, and shall supersede all prior correspondence, agreements and understandings concerning such matters, whether oral or written. No addition
to, or amendment or modification of, any term or provision of this Sublease shall be effective unless set forth in writing and signed by Sublessor and Sublessee. 

        (b)    Authority.    Each individual executing this Sublease on behalf of either party represents and warrants that he
or she is duly authorized to execute and deliver this Sublease on behalf of such party. 

        (c)    Attorneys' Fees.    If either party commences an action against the other party arising out of or in connection
with this Sublease, or for interpretation of any of its provisions, the prevailing party shall be entitled to recover its costs and expenses, including reasonable attorneys' fees and court costs, from
the other party. In addition, if either Sublessor or Sublessee becomes a party to any action concerning this Sublease or the Premises solely by reason of the neglect or omission of any duty by the
other party, the party subjected to such action without fault shall be entitled to reimbursement for any and all reasonable attorneys' fees and costs. 

        (d)    Captions.    All captions and headings in this Sublease are for the purposes of reference and convenience and
shall not limit or expand the provisions of this Sublease. 

        (e)    Counterparts.    This Sublease may be executed in one or more counterparts, each of which shall constitute an
original, and all of which shall constitute a single agreement. 

        (f)    Conflicts.    In the event of any conflict between this Sublease and the Lease, as between Sublessor and
Sublessee the terms and conditions of this Sublease shall control. 

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        IN
WITNESS WHEREOF, Sublessor and Sublessee have executed this Sublease on the dates set out below. 

	SUBLESSOR:	 	SUBLESSEE:
	

COULTER PHARMACEUTICAL, INC.,

a Delaware corporation	
 	

CORGENTECH, INC.,

a Delaware corporation
	

By:	

/s/  STEVEN GILLIS      
	
 	

By:	

/s/  RICHARD POWERS      

	

Title:	

President
	
 	

Title:	

Vice President and Chief Financial Officer

	

Date:	

5/15/03
	
 	

Date:	

5/15/03

16

EXHIBIT A

LEASE  

QuickLinks

Exhibit 10.6

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00059-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00059-of-00352.parquet"}]]