Document:

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                                                                   Exhibit 10.19

                                                               Execution Version

                   AMENDMENT NO.2 TO ASSET PURCHASE AGREEMENT

     This Amendment No.2 to the Asset Purchase Agreement (this "Amendment No.2")
is entered into as of February 2, 2005, by and among SmithKline Beecham
Corporation (doing business as GlaxoSmithKline), a Pennsylvania corporation (the
"Buyer"), Corixa Corporation, a Delaware corporation ("Corixa"), Coulter
Pharmaceutical, Inc., a Delaware corporation and wholly-owned subsidiary of
Corixa ("Coulter"), (Corixa and Coulter being hereinafter collectively and/or
individually referred to, as the context requires and admits, as the "Sellers").
The Sellers, on the one hand, and the Buyer, on the other hand, are each
referred to herein as a "Party" and, collectively, as the "Parties."

                                    RECITALS

     WHEREAS, the Parties entered into that certain Asset Purchase Agreement
dated as of December 12, 2004 in connection with the Sellers' sale and the
Buyer's purchase of the Assets, as amended as of December 31, 2004 (the
"Agreement"); and

     WHEREAS, since the date of the Agreement's first amendment on December 31,
2004, the Parties have identified an additional employee of the Sellers who will
be participating in the Transition Plans as a Scheduled Employee.

                                    AGREEMENT

     NOW, THEREFORE, in consideration of the mutual agreements contained herein
and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, and pursuant to Section 9.2 of the Agreement, the
Parties hereby agree as follows:

1.   SCHEDULED EMPLOYEES.

     Schedule 7.2 to the Agreement is hereby deleted in its entirety and
replaced with EXHIBIT A attached hereto.

2.   DEFINED TERMS.

     Capitalized terms that are used, but not otherwise defined, in this
Amendment No.2 shall have the meaning ascribed to them in the Agreement.

3.   GOVERNING LAW.

     This Amendment No.2 and all acts and transactions pursuant hereto shall be
governed, construed and interpreted in accordance with the Laws of the state of
New York, without giving effect to principles of conflict of Laws.

4.   COUNTERPARTS.

     This Amendment No.2 may be executed in two or more counterparts, each of
which shall be deemed an original and all of which together shall constitute one
instrument.

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5.   ENTIRE AGREEMENT.

     The terms of the Agreement, as amended hereby, shall remain in full force
and effect. All references to the "Agreement" contained therein shall mean the
Agreement, as amended on December 31, 2004 and further amended by this Amendment
No.2.

                            [signature page follows]

                                       -2-

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     IN WITNESS WHEREOF, this Amendment No.2 has been duly executed and
delivered by the duly authorized representatives of each Seller and the Buyer as
of the date first above written.

                                        THE BUYER:

                                        SMITHKLINE BEECHAM CORPORATION
                                        (D/B/A GLAXOSMITHKLINE)

                                        By: /s/ DONALD F. PARMAN
                                            ------------------------------------
                                            Name: Donald F. Parman
                                            Title: Vice President & Secretary

                                        THE SELLERS:

                                        CORIXA CORPORATION

                                        By: /s/ STEVEN GILLIS
                                            ------------------------------------
                                            Name: Steven Gillis
                                            Title: CEO

                                        COULTER PHARMACEUTICAL, INC.

                                        By: /s/ STEVEN GILLIS
                                            ------------------------------------
                                            Name: Steven Gillis
                                            Title: President<PAGE>
                                                                   Exhibit 10.47

            FIRST AMENDMENT TO SECURITY AGREEMENT: SECURITIES ACCOUNT

     This First Amendment to Security Agreement: Securities Account ("First
Amendment") is made and entered into as of the 28th day of February, 2005 by and
between CORIXA CORPORATION, a Delaware corporation ("Debtor"), and NDC NEW
MARKETS INVESTMENTS IV, L.P., a Delaware limited partnership ("Lender").

     WHEREAS, Debtor executed that certain Security Agreement: Securities
Account dated March 2, 2004 wherein Debtor granted a security interest in that
certain Securities Account (as therein defined) held at Wells Fargo Bank,
National Association; and

     WHEREAS, the Debtor and Lender executed that certain Addendum to Security
Agreement: Securities Account dated March 2, 2004 wherein Debtor agreed to
maintain a Collateral Value (as therein defined) in the Securities Account of at
least $14,550,000; and

     WHEREAS, in connection with the execution of the Security Agreement, the
Debtor executed that certain Securities Account Control Agreement wherein the
Debtor agreed to maintain in the Securities Account (as therein defined) a
minimum market value of $14,550,000; and

     WHEREAS, the Debtor and Lender desire to amend both the Security Agreement:
Securities Account and the Securities Account Control Agreement to provide that
the minimum Collateral Value held in the Securities Account shall be at least
$14,550,000 plus three months of interest calculated at the rate set forth in
the Promissory Note secured by the Security Agreement.

     NOW THEREFORE, for and in consideration of their mutual promises, the
Debtor and Lender each agree as follows:

     1. Amendment to Addendum to Security Agreement: Securities Account. The
Debtor and Lender each agree to amend paragraph 1 of the Addendum to provide
that the minimum Collateral Value shall be $14,550,000 plus three months of
interest on such principal amount calculated at the rate set forth in the
Promissory Note, such that after such amendment paragraph 1 shall be and
hereinafter read as follows:

          "1. Securities Account Activity. So long as no Event of Default
exists, Debtor, or any party authorized by Debtor to act with respect to the
Securities Account, may (a) receive payments of interest and/or cash dividends
earned on financial assets maintained in the Securities Account, (b) trade
financial assets maintained in the Securities Account, so long as each trade of
a financial asset is for an investment property of the same type as the
financial asset being traded, and (c) withdraw financial assets from the
Securities Account, so long as after giving effect to such withdrawal, (i) the
Collateral Value of the Securities Account is not less than the amount required
below, and (ii) the market value of the Securities Account is not less than
$14,550,000.00 plus three months of interest at the rate set forth in the
Promissory Note secured by this Agreement, which minimum market value may be
reduced in accordance with the terms and conditions of this Section. Without
Lender's prior written consent, except as permitted by the preceding sentence,
neither Debtor nor any party other thank Lender may withdraw or receive any
distribution of any Collateral from the Securities Account. The Collateral Value
of the Securities Account shall at all times be equal to or greater than
$14,550,000.00 plus three months of interest at the rate set forth in the
Promissory Note secured by this Agreement, which minimum market value may be
reduced if the principal amount of the Loan is reduced in accordance with
Section 1.5 of the Credit Agreement. Any reduction of the minimum market value
of the Securities Account shall be made in an increment to correspond to a
reduction in the principal amount of the Loan. In the event that the Collateral
Value, for any reason and at any time, is less than the required amount, Debtor
shall promptly make a principal

First Amendment to Security Agreement: Securities Account                 Page 1

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reduction on the Indebtedness or deposit additional assets of a nature
satisfactory to Lender into the Securities Account, in either case in amounts or
with values sufficient to achieve the required Collateral Value."

     2. Amendment to Securities Account Control Agreement. The Debtor and Lender
each agree to amend paragraph 3(a) of the Securities Account Control Agreement
to provide that the minimum Collateral Value shall be $14,550,000 plus three
months of interest on such principal amount calculated at the rate set forth in
the Promissory Note, such that after such amendment paragraph 3(a) shall be and
hereinafter read as follows:

     (a) Until Intermediary is notified otherwise by Secured Party: (i)
Customer, or any party authorized by Customer to act with respect to the
Securities Account, may give trading instructions to Intermediary with respect
to Collateral in the Securities Account so long as each trade of a financial
asset is for an investment property of the same type as the financial asset
being traded; (ii) Intermediary may distribute to Customer or any other party in
accordance with Customer's directions that portion of the Collateral which
consists of interest and/or cash dividends earned on financial assets maintained
in the Securities Account; and (iii) Intermediary may permit Customer to
withdraw financial assets from the Securities Account so long as after giving
effect to any such withdrawal, the market value of the Securities Account is not
less than $14,550,000.00 plus three months of Interest at the rate set forth in
the Promissory Note secured by this Agreement, which minimum market value may be
reduced if the principal amount of the Loan is reduced in accordance with
Section 1.5 of the Credit Agreement. Any reduction of the minimum market value
of the Securities Account shall be made in an increment to correspond to a
reduction in the principal amount of the Loan. At no time during the term of the
Loan shall the principal amount of the Loan exceed the required minimum market
value of the Securities Account.

     3. Corporate Authority. The Debtor has the corporate power to execute and
deliver this First Amendment and to perform all of its obligations in connection
herewith and therewith. The execution and delivery by the Debtor of this First
Amendment and the performance of its obligations in connection herewith and
therewith: (i) have been duly authorized or will be duly ratified and affirmed
by all requisite corporate action; (ii) will not violate any provision of law,
any order of any court or agency of government or the Articles of Incorporation
or Bylaws of such entity; (iii) will not be in conflict with, result in a breach
of or constitute (alone or with due notice or lapse of time or both) a default
under any agreement or other instrument; and (iv) will not require any
registration with, consent or approval of or other action by any federal, state,
provincial or other governmental authority or regulatory body.

     4. Ratification of Obligation. The Debtor does here acknowledge, ratify and
confirm that it is obligated and indebted to Lender as evidenced by the Credit
Agreement (as defined in the Security Agreement), the Security Agreement:
Securities Account and all other loan documents executed in connection with the
Credit Agreement.

     5. Ratification of Agreements. The Security Agreement : Securities Account,
as hereby amended, is acknowledged, ratified and confirmed in all respects as
being valid, existing, and of full force and effect. Any reference to the
Security Agreement in the Credit Agreement or any loan document shall be deemed
to be a reference to the Security Agreement as amended by this First Amendment.
The execution, delivery and effectiveness of this First Amendment shall not,
except as expressly provided herein, operate as a waiver of any right, power or
remedy of Lender under the Credit Agreement, nor constitute a waiver of any
provision of the Credit Agreement.

First Amendment to Security Agreement: Securities Account                 Page 2

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     6. Governing Law. This First Amendment shall be governed by and construed
in all respects in accordance with the laws of the State of Washington and any
applicable laws of the United States of America, including construction,
validity and performance.

     7. Counterparts. This First Amendment may be separately executed in any
number of counterparts and by different parties hereto in separate counterparts,
each of which when so executed shall be deemed to constitute one and the same
First Amendment.

     8. ENTIRE AGREEMENT. THIS FIRST AMENDMENT, TOGETHER WITH ANY LOAN DOCUMENTS
EXECUTED IN CONNECTION HEREWITH, CONTAINS THE ENTIRE AGREEMENT BETWEEN THE
PARTIES HERETO RELATING TO THE SUBJECT MATTER HEREOF AND THEREOF AND ALL PRIOR
AGREEMENTS RELATIVE THERETO WHICH ARE NOT CONTAINED HEREIN OR THEREIN ARE
TERMINATED. THERE ARE NO UNWRITTEN ORAL AGREEMENTS BETWEEN THE PARTIES. THIS
FIRST AMENDMENT, AND THE LOAN DOCUMENTS MAY BE AMENDED, REVISED, WAIVED,
DISCHARGED, RELEASED OR TERMINATED ONLY BY A WRITTEN INSTRUMENT OR INSTRUMENTS,
EXECUTED BY THE PARTY AGAINST WHICH ENFORCEMENT OF THE AMENDMENT, REVISION,
WAIVER, DISCHARGE, RELEASE OR TERMINATION IS ASSERTED. ANY ALLEGED AMENDMENT,
REVISION, WAIVER, DISCHARGE, RELEASE OR TERMINATION WHICH IS NOT SO DOCUMENTED
SHALL NOT BE EFFECTIVE AS TO ANY PARTY.

     IN WITNESS WHEREOF, this First Amendment is executed effective as of the
date first written above.

DEBTOR:                                 CORIXA CORPORATION

                                        By: /s/ GREGORY COX
                                            ------------------------------------
                                        Its: Treasurer

LENDER:                                 NDC NEW MARKETS INVESTMENTS IV, L.P.

                                        By: HEDC New Markets, Inc.
                                        Its: General Partner

                                        By: /s/ Robert W. Davenport
                                            ------------------------------------
                                            Robert W. Davenport, Chairman

First Amendment to Security Agreement: Securities Account                 Page 3

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