Document:

SECOND AMENDED AND RESTATED
                    FORBEARANCE, LOCK-UP AND VOTING AGREEMENT

         This  SECOND  AMENDED  AND  RESTATED  FORBEARANCE,  LOCK-UP  AND VOTING
AGREEMENT (this  "Agreement") is made and entered into as of May 18, 2000 by and
between Innovative Clinical Solutions,  Ltd., a Delaware  corporation ("ICSL" or
the  "Company"),  and the holders  listed on the Schedule of Consenting  Holders
attached hereto, (each, a "Consenting Holder," and collectively, the "Consenting
Holders").  The Company and the Consenting Holders are collectively  referred to
herein as the "Parties" and individually as a "Party."

                                    RECITALS

         WHEREAS,  ICSL and the Consenting  Holders have previously entered into
that certain  Forbearance,  Lock-Up and Voting Agreement dated as of January 17,
2000 (as amended and restated by that certain Amended and Restated  Forbearance,
Lock-Up  and  Voting  Agreement  dated  as  of  April  7,  2000,  the  "Original
Agreement") with regard to  restructuring  the  indebtedness  outstanding  under
ICSL's 6 3/4% Convertible Subordinated Debentures due 2003 (the "Old Convertible
Subordinated Debentures");

         WHEREAS,  ICSL and the  Consenting  Holders  now  desire  to amend  and
restate the Original  Agreement  and  implement a financial  restructuring  (the
"Financial  Restructuring")  of  ICSL  pursuant  to a  pre-packaged  Chapter  11
bankruptcy  filing  by  ICSL  and  all of  its  wholly-owned  subsidiaries  (the
"Subsidiaries")  on the  terms set forth in this  Agreement  and the Term  Sheet
attached as Exhibit A hereto (the "Term Sheet");

         WHEREAS,  in order to implement the Financial  Restructuring,  ICSL and
the Subsidiaries intend,  subject to the terms and conditions of this Agreement,
to, (i)  prepare  and,  if  necessary,  file with the  Securities  and  Exchange
Commission a Prepetition Disclosure and Solicitation Document (the "Solicitation
Document") containing "adequate  information" as such term is defined in section
1125(a) of title 11 of the United  States  Code (the  "Bankruptcy  Code");  (ii)
prepare a plan of reorganization  (the "Prepackaged  Plan") consistent with this
Agreement  and the  Term  Sheet;  (iii)  solicit  requisite  acceptances  of the
Prepackaged  Plan from holders of impaired  claims prior to the  commencement of
proceedings   under  chapter  11  of  the  Bankruptcy   Code  (the  "Chapter  11
Proceedings");  and (iv) if requisite  acceptances  are  obtained,  commence the
Chapter 11 Proceedings to implement the terms of the Financial Restructuring;

         WHEREAS,  in order to facilitate  the  implementation  of the Financial
Restructuring,  the Consenting  Holders are prepared to commit,  as set forth in
more detail herein,  during the period  commencing on the date hereof and ending
on the date a Termination Event (as defined herein) first occurs, and no longer,
(i) to forbear  from  exercising  remedies  in  respect  of the Old  Convertible
Subordinated Debentures, and (ii) not to sell, transfer or assign any of the Old
Convertible Subordinated Debentures except as permitted herein;

                                       1

         WHEREAS,  the Consenting  Holders are prepared to commit,  on the terms
and subject to the  conditions  of this  Agreement,  to consent to a Prepackaged
Plan that satisfies the Conditions (as defined herein).

         NOW,  THEREFORE,  in  consideration  of the  premises  and  the  mutual
covenants  and  agreements  set forth  herein,  and for other good and  valuable
consideration,  the receipt and  sufficiency  of which are hereby  acknowledged,
ICSL and the Consenting Holders hereby agree as follows:

         1.  Forbearance.  During the period  commencing  on the date hereof and
ending on the date that a Termination Event first occurs, and no longer, each of
the  Consenting  Holders  hereby  agrees to forebear (and agrees not to give any
instructions  to the trustee under the Old  Convertible  Subordinated  Debenture
Indenture inconsistent with such forbearance) from the exercise of any rights or
remedies it may have under or with respect to the Old  Convertible  Subordinated
Debentures  or  the  Old  Convertible   Subordinated  Debenture  Indenture  (the
"Existing Agreements"), applicable law or otherwise, with respect to any default
in existence or arising under the Existing Agreements; provided, however, during
such period,  ICSL shall have continued to comply with its obligations under the
terms and conditions of this  Agreement.  In the event that this Agreement shall
terminate, the Consenting Holders shall have, and shall be entitled to exercise,
each of their rights or remedies  under the Existing  Agreements  and applicable
law, as if this  Agreement  was never  executed (and shall not be deemed to have
waived any such rights or remedies by virtue of executing this Agreement).

         2.  Voting,  Consent  and/or  Tender.  Each of the  Consenting  Holders
represents  that, as of the date hereof,  it is the beneficial  owner and/or the
investment  adviser or manager for the beneficial  owner (with the power to vote
and  dispose  of Old  Convertible  Subordinated  Debentures  on  behalf  of such
beneficial  owner) of Old Convertible  Subordinated  Debentures set forth on the
schedule  attached to its  signature  page (for each such Party,  the  "Relevant
Claims").  Each of the Consenting  Holders agrees that, subject to the condition
that the terms of the  Prepackaged  Plan and all  documents  attendant  thereto,
including,  without limitation,  the terms, financial instruments,  and security
documents  (if  any)  to be  provided  to the  holders  of the  Old  Convertible
Subordinated Debentures (collectively, the "Attendant Documents"),  contained in
the  Solicitation   Document  relating  to  the  Old  Convertible   Subordinated
Debentures  include and/or are  consistent  with the terms set forth in the Term
Sheet,  and are in form and substance  satisfactory  in all other  respects,  it
shall timely vote (including  instructing  custodial agents to vote, as the case
may be) the entirety of its Relevant Claims to accept the Prepackaged Plan. Each
of the Consenting  Holders also agrees that,  subject to the conditions that (i)
all classes of impaired  claims  shall have  accepted  the  Prepackaged  Plan as
provided in section  1126(c) of the  Bankruptcy  Code, and (ii) the court in the
Chapter 11 Proceedings  the  "Bankruptcy  Court") shall have determined that the
solicitation  of  holders of  impaired  claims was in  compliance  with  section
1126(b) of the Bankruptcy  Code, it shall not withdraw or revoke its vote except
as permitted  herein.  Each of the  conditions set forth in this Section 2 shall
hereinafter be referred to collectively as the "Conditions".

                                       2

         3.  Restriction  on Transfer.  Each of the  Consenting  Holders  hereby
agrees that,  during the period  commencing on the date hereof and ending on the
date that a Termination  Event first occurs,  and no longer,  it shall not sell,
transfer or assign any of the Relevant Claims or any option thereon or any right
or interest (voting or otherwise) therein,  unless the transferee thereof agrees
in  writing  to be  bound by all the  terms of this  Agreement  by  executing  a
counterpart  signature page of this  Agreement and the transferor  provides ICSL
with a copy  thereof,  in which event ICSL shall be deemed to have  acknowledged
that its  obligations to the  Consenting  Holders  hereunder  shall be deemed to
constitute obligations in favor of such transferee,  and ICSL shall confirm that
acknowledgment in writing.

         4. ICSL  Agreements.  ICSL  hereby  agrees to use its  reasonable  best
efforts to have the  prepetition  solicitation  of holders  of  impaired  claims
approved by the Bankruptcy  Court pursuant to section  1126(b) of the Bankruptcy
Code, and shall  thereafter take all reasonable steps necessary and desirable to
obtain an order of the  Bankruptcy  Court  confirming  the  Prepackaged  Plan as
expeditiously  as possible under the  provisions,  rules and  regulations of the
Bankruptcy Code and the Bankruptcy Rules.

         5. Support of the Plan.  ICSL will use its  reasonable  best efforts to
obtain the  required  consent of 66-2/3% of the  holders of the Old  Convertible
Subordinated  Debentures  to  the  Prepackaged  Plan  and  confirmation  of  the
Prepackaged  Plan in accordance  with the Bankruptcy  Code as  expeditiously  as
possible. The Consenting Holders will take all necessary and appropriate actions
to support the Prepackaged  Plan and the  confirmation  thereof.  The Consenting
Holders shall not (a) object to the  Solicitation  Document or confirmation of a
Prepackaged  Plan that  satisfies  the  Conditions  or  otherwise  commence  any
proceeding to oppose or alter a Prepackaged  Plan that  satisfies the Conditions
or  any  other  reorganization  documents  containing  terms  that  satisfy  the
Conditions,  (b) vote for, consent to, support or participate in the formulation
of any other plan of  reorganization  or liquidation  proposed or filed or to be
proposed  or filed in any chapter 11 or chapter 7 case  commenced  in respect of
ICSL  provided that ICSL is  supporting a  Prepackaged  Plan that  satisfies the
Conditions,  (c) directly or indirectly seek, solicit,  support or encourage any
other  plan,  proposal  or  offer  of  dissolution,   winding  up,  liquidation,
reorganization,  merger or restructuring of ICSL or any of its subsidiaries that
could  reasonably  be  expected  to  prevent,  delay or  impede  the  successful
restructuring of ICSL as contemplated by the Prepackaged Plan, provided that the
Prepackaged  Plan  satisfies  the  Conditions,  (d)  object to the  Solicitation
Document or the solicitation of consents to the Prepackaged Plan,  provided that
the Prepackaged Plan satisfies the Conditions, or (e) take any other action that
is inconsistent  with, or that would delay confirmation of the Prepackaged Plan,
provided that the Prepackaged Plan satisfies the Conditions.

          6. Acknowledgment. This Agreement is not and shall not be deemed to be
a  solicitation  for consents to the  Prepackaged  Plan.  The  acceptance of the
Consenting  Holders  will not be  solicited  until the  Consenting  Holders have
received the Solicitation Document and related documents.

         7. Termination of this Agreement and Consenting Holders's  Obligations.
The Consenting Holders may terminate their obligations hereunder and rescind any
consent to the Prepackaged Plan by such Consenting  Holders (which consent shall

                                       3

be null and void and have no further force and effect) and this Agreement  shall
terminate if any of the following events (any such event, a "Termination Event")
occur:   (i)  ICSL  files,   propounds  or   otherwise   supports  any  plan  of
reorganization or liquidation that does not satisfy the Conditions; and (ii) the
Prepackaged Plan is modified or replaced such that it (or any such  replacement)
at any time does not satisfy the Conditions;  (iii) the Solicitation Document is
not  distributed to holders of impaired  claims on or before June 5, 2000;  (iv)
the Chapter 11 Proceedings are not commenced on or before July 15, 2000; (v) the
Prepackaged  Plan is not consummated on or before October 20, 2000; or (vi) ICSL
shall have  disclaimed in writing its intention to pursue the  restructuring  or
has otherwise  materially  breached this  Agreement and shall not have cured any
breach within thirty (30) days of receiving written notices thereof.

          8.  Representations  and  Warranties.  Each of ICSL and the Consenting
Holders represents and warrants to each other the following statements are true,
correct and complete as of the date hereof:

                  (a)  Power  and  Authority.  It has all  requisite  power  and
authority  to  enter  into  this  Agreement  and to carry  out the  transactions
contemplated by, and perform its respective obligations under, this Agreement.

                  (b)   Authorization.   The  execution  and  delivery  of  this
Agreement  and the  performance  of its  obligations  hereunder  have  been duly
authorized by all necessary corporate,  trust,  partnership or LLC action on its
part.

                  (c) No Conflicts.  The execution,  delivery and performance by
it of this Agreement do not and shall not (i) violate any provision of law, rule
or regulation  applicable to it or any of its subsidiaries or its Certificate of
Incorporation or bylaws or other organizational documents or those of any of its
subsidiaries  or (ii) conflict with,  result in a breach of or constitute  (with
due notice or lapse of time or both) a default  under any  material  contractual
obligation to which it or any of its subsidiaries is a party.

                  (d)  Governmental  Consents.   The  execution,   delivery  and
performance  by  it  of  this  Agreement  do  not  and  shall  not  require  any
registration  or filing  with,  consent or  approval  of, or notice to, or other
action to, with or by, any  federal,  state or other  governmental  authority or
regulatory  body,  except such filings as may be necessary  and/or  required for
disclosure by the Securities and Exchange  Commission and in connection with the
commencement of the Chapter 11 Proceedings, the approval of the Solicitation and
confirmation of the Prepackaged Plan.

                  (e) Binding  Obligation.  This  Agreement is the legally valid
and binding  obligation of it,  enforceable  against it in  accordance  with its
terms,  except  as  enforcement  may  be  limited  by  bankruptcy,   insolvency,
reorganization,  moratorium  or  other  similar  laws  relating  to or  limiting
creditors'   rights   generally   or  by   equitable   principles   relating  to
enforceability.

          9. Further  Acquisition of Securities.  This Agreement shall in no way
be construed  to preclude  the  Consenting  Holders  from  acquiring  additional

                                       4

Claims.  However,  any such additional Claims so acquired shall automatically be
deemed to be Relevant Claims and to be subject to the terms of this Agreement.

          10.  Amendments.  This  Agreement  may  not be  modified,  amended  or
supplemented except in writing signed by ICSL and the Consenting Holders.

         11. Disclosure.  Unless required by applicable law or regulation,  ICSL
shall not disclose any of the Consenting  Holders'  holdings of Relevant  Claims
without the prior written consent of the applicable  Consenting  Holder,  and if
such announcement or disclosure is so required by law or regulation,  ICSL shall
afford such  Consenting  Holders a reasonable  opportunity to review and comment
upon  any  such  announcement  or  disclosure  prior  to  such  announcement  or
disclosure.  The foregoing  shall not prohibit ICSL from disclosing the names of
the Consenting  Holders or the existence and terms of this Agreement;  provided,
however,   that  any  press  release  of  ICSL  naming  the  Consenting  Holders
(individually  or as an ad hoc committee)  shall be acceptable to the Consenting
Holders, such approval not to be unreasonably withheld, delayed or denied.

         12.  Impact of  Appointment  to  Creditors  Committee.  If an  official
committee of unsecured  creditors or of holders of Old Convertible  Subordinated
Debentures is appointed by the United States Trustee in a Chapter 11 Proceeding,
to the extent  that the  Consenting  Holders  wish,  in their sole and  absolute
discretion,  to be appointed to any official committee of unsecured creditors or
holders of Old Convertible  Subordinated  Debentures,  ICSL shall cooperate with
the Consenting  Holders in seeking to cause the United States Trustee to appoint
the  Consenting  Holders to be a member of an  official  committee  pursuant  to
Section 1102 of the  Bankruptcy  Code.  Notwithstanding  anything  herein to the
contrary,  in the event that any of the Consenting  Holders are appointed to and
serve on a committee  of creditors  or holders of Old  Convertible  Subordinated
Debentures in a Chapter 11 Proceeding,  the terms of this Agreement shall not be
construed so as to limit such  Consenting  Holder's  exercise (in their sole and
absolute  discretion)  of its  fiduciary  duties to any person  arising from its
service  on such  committee,  and any such  exercise  (in the sole and  absolute
discretion of such  Consenting  Holders) of such  fiduciary  duties shall not be
deemed to  constitute a breach of the terms of this  Agreement  (but the fact of
such  service  on such  committee  shall not  otherwise  affect  the  continuing
validity or enforceability of this Agreement).

         13.  Notices.  All  notices,   requests,   claims,  demands  and  other
communications  hereunder  shall be in  writing  (including  by  facsimile  with
written  confirmation  thereof) and unless otherwise  expressly provided herein,
shall be delivered  during normal  business  hours by hand, by Federal  Express,
United  Parcel  Service  or other  nationally  recognized  overnight  commercial
delivery  service,  or by facsimile  notice,  confirmation of receipt  received,
addressed as follows,  or to such other address as may be hereafter  notified by
the respective parties hereto:

                                       5

                  (1)      If to the Consenting Holders:

                           767 Third Avenue
                           New York, New York   10017
                           Attention:       Martin J. Whitman
                           Facsimile Number:         (212) 888-6704

                  With a copy, which will not constitute notice, to:

                           White & Case
                           1155 Avenue of the Americas
                           New York, New York 10036-2787
                           Attention:       Andrew DeNatale
                           Facsimile Number:         212-354-8113

                  (2)      If to the Company:

                           Innovative Clinical Solutions, Ltd.
                           10 Dorrance Street
                           Suite 400
                           Providence, Rhode Island  02903
                           Attention: Michael Heffernan
                           Facsimile Number: 401-831-6758

                  With a copy, which will not constitute notice, to:

                           Katten Muchin Zavis
                           525 West Monroe
                           Suite 1300
                           Chicago, Illinois   60661
                           Attention: Jeff J. Marwil, Esq.
                           Facsimile Number: 312-902-1061

         14.  Governing Law;  Jurisdiction.  This Agreement shall be governed by
and  construed in  accordance  with the internal  laws of the State of Delaware,
without  regard to any  conflicts  of law  provision  which  would  require  the
application of the law of any other jurisdiction.  By its execution and delivery
of  this  Agreement,   each  of  the  Parties  hereto  hereby   irrevocably  and
unconditionally  agrees for itself  that any legal  action,  suit or  proceeding
against it with respect to any matter  under or arising out of or in  connection
with this Agreement or for  recognition or enforcement of any judgment  rendered
in any such action, suit or proceeding,  may be brought in the District Court of
Delaware.  By  execution  and  delivery of this  Agreement,  each of the parties
hereto  hereby  irrevocably  accepts  and  submits  itself  to the  nonexclusive
jurisdiction of each such court, generally and unconditionally,  with respect to
any such action,  suit or proceeding.  Notwithstanding  the foregoing consent to
Delaware jurisdiction, upon the commencement of any Chapter 11 Proceedings, each

                                       6

of the  Parties  hereto  hereby  agrees  that the  Bankruptcy  Court  shall have
exclusive  jurisdiction of all matters arising out of or in connection with this
Agreement.

         15.  Specific  Performance.  It is understood and agreed by each of the
Parties  hereto  that money  damages  would not be a  sufficient  remedy for any
breach of this  Agreement  by any Party and each  non-breaching  Party  shall be
entitled to specific  performance and injunctive or other equitable  relief as a
remedy of any such breach.

         16. Headings. The headings of the sections, paragraphs and subsections
of this  Agreement  are inserted for  convenience  only and shall not affect the
interpretation hereof.

         17.  Successors  and Assigns.  This  Agreement is intended to bind and
inure to the benefit of the Parties and their  respective  successors,  assigns,
heirs, executors, administrators and representatives.

         18. Prior  Negotiations.  This Agreement and the Term Sheet  supersede
the Original  Agreement and all prior  negotiations  with respect to the subject
matter hereof.

         19.  Counterparts.  This  Agreement  may be  executed  in one or  more
counterparts,  each of which shall be deemed an original  and all of which shall
constitute one and the same Agreement.

         20. No Third-Party Beneficiaries. Unless expressly stated herein, this
Agreement  shall be solely for the  benefit of the  Parties  hereto and no other
person or entity shall be a third-party beneficiary hereof.

         21.  Consideration.  It is hereby  acknowledged  by the Parties  hereto
that, except as otherwise set forth in the Term Sheet, no consideration shall be
due or paid to the  Consenting  Holders  for their  agreement  to consent to the
Prepackaged  Plan in accordance  with the terms and conditions of this Agreement
other  than  ICSL's  agreement  to use its  reasonable  best  efforts  to obtain
approval of  Prepackaged  Plan and to take all steps  necessary and desirable to
confirm the Prepackaged Plan in accordance with the terms and conditions of this
Agreement.

                                       7

         IN  WITNESS  WHEREOF,  each  of the  parties  hereto  has  caused  this
Agreement to be executed and delivered by its duly authorized  officer as of the
date first above written.

                          INNOVATIVE CLINICAL SOLUTIONS, LTD.

                          By:      /s/Gary S. Gillheeney
                                   -------------------------------------------
                          Name:    Gary S. Gillheeney
                                   -------------------------------------------
                          Title:   Chief Financial Officer
                                 ---------------------------------------------

                          THIRD AVENUE TRUST ON BEHALF OF THE
                          THIRD AVENUE VALUE FUND SERIES

                          By:      /s/ Martin J. Whitman
                                   -------------------------------------------
                          Name:    Martin Whitman
                                   -------------------------------------------
                          Title:   Chairman
                                   -------------------------------------------

                          M.J. WHITMAN PILOT FISH OPPORTUNITY
                          FUND LP

                          By:      M.J. Whitman Pilot Fish Opportunity Fund
                                   Inc., general partner

                          By:      /s/ David Barse
                                   -------------------------------------------
                          Name:    David Barse
                                   -------------------------------------------
                          Title:   President
                                   -------------------------------------------

                                       8

9

                         SCHEDULE OF CONSENTING HOLDERS

              Holder                     Principal Amount of Debentures
     Third Avenue Value Fund                      $49,155,000

M.J. Whitman Pilot Fish Opportunity
            Fund LP                                $1,750,000

                                       9<PAGE>
                                                                   EXHIBIT 10.63
                            SECURED PROMISSORY NOTE
                            -----------------------

                                                              June 17, 1996
$500,000                                                Cambridge, Massachusetts

     FOR VALUE RECEIVED, Doros Platika (the "Maker"), promises to pay to
Ontogeny, Inc. (the "Company"), or order, the principal sum of $500,000,
together with interest on the unpaid principal balance of this Note from time to
time outstanding at the rate of 6.58% per year until paid in full. Principal and
all accrued but unpaid interest shall be paid upon the earliest of (i) June 30,
2003, (ii) 30 days after Maker's voluntary resignation as an employee of the
Company without Good Reason (as defined in the Employment Agreement dated as of
June 17, 1996 between Maker and the Company) and (iii) 180 days after any
termination of Maker's employment by the Company other than by reason of his
voluntary resignation without Good Reason. Accrued interest shall be paid, in
arrears, on June 30 of each year.

     All payments by the Maker under this Note shall be in immediately available
funds.

     Payment of this Note is secured by a security interest in certain property
of the Maker ("the Collateral") pursuant to a pledge agreement of even date
herewith between the Maker and the Company (the "Pledge Agreement") and a
mortgage of even date herewith between the Maker and the Company (the
"Mortgage").

     This Note shall become immediately due and payable without notice or demand
upon the occurrence at any time of any of the following events of default
(individually, "an Event of Default" and collectively, "Events of Default"):

     (1)  default in the payment when due of any principal or interest under
          this Note, which is not cured within 30 days after written notice
          thereof;

     (2)  the occurrence of any event of default under the Pledge Agreement or
          Mortgage, which is not cured within 30 days after written notice
          thereof; or

     (3)  the institution by or against the Maker of any proceedings under the
          United States Bankruptcy Code or any other federal or state
          bankruptcy, reorganization, receivership, insolvency or other similar
          law affecting the rights of creditors generally.

<PAGE>

     Upon the occurrence of an Event of Default, the holder shall have then, or
at any time thereafter, all of the rights and remedies afforded by the Uniform
Commercial Code as from time to time in effect in the Commonwealth of
Massachusetts or afforded by other applicable law.

     No reference in this Note to the Pledge Agreement or Mortgage shall impair
the obligation of the Maker, which is absolute and unconditional, to pay all
amounts under this Note strictly in accordance with the terms of this Note.

     No delay or omission on the part of the holder in exercising any right
under this Note, the Security Agreement or Mortgage shall operate as a waiver of
such right or of any other right of such holder, nor shall any delay, omission
or waiver on any one occasion be deemed a bar to or waiver of the same or any
other right on any future occasion. The Maker waives presentment, demand,
protest and notices of every kind and assents to any extension or postponement
of the time of payment or any other indulgence, to any substitution, exchange or
release of collateral.

     This Note may be prepaid in whole or in part at any time or from time to
time.

     None of the terms or provisions of this Note may be excluded, modified or
amended except by a written instrument duly executed on behalf of the holder
expressly referring to this Note and setting forth the provision so excluded,
modified or amended.

     All rights and obligations hereunder shall be governed by the laws of the
Commonwealth of Massachusetts and this Note is executed as an instrument under
seal.

                                        /s/ Doros Platika
                                        -----------------------
                                            Doros Platika

                                       2
<PAGE>

                  FIRST AMENDMENT TO SECURED PROMISSORY NOTE
                  ------------------------------------------

     This First Amendment to Secured Promissory Note is made as of the 31 day of
August, 1998.

     Reference is hereby made to that certain Secured Promissory Note dated June
17, 1996 from Doros Platika (the "Maker") in favor of Ontogeny, Inc. (the
"Company") in the original principal amount of $500,000.00 (the "Note").

     WHEREAS, the Maker and the Company wish to amend the Note on the terms and
conditions hereinafter set forth.

     NOW, THEREFORE, for good and valuable consideration the receipt and
sufficiency of which are hereby acknowledged, the Maker and the Company hereby
agree that the Note is amended as follows:

     1.   The fourth paragraph of the Note (beginning "Payment of this Note") is
hereby deleted and replaced with the following:

     "Payment of this Note is secured by a mortgage dated August 31, 1998 from
     the Maker and Patricia C. Platika to the Company (the "Mortgage").

     2.   Except as hereby amended, the Note remains in full force and effect
and the parties hereto ratify and confirm the same.

     EXECUTED as a sealed instrument as of the date first above written.

                                             MAKER:

                                             /s/ Doros Platika
                                             -------------------------------
                                             Doros Platika

                                             COMPANY:

                                             ONTOGENY, INC.

                                             By: /s/ George A. Eldridge
                                                ----------------------------
                                                     George A. Eldridge
                                                     Vice President Finance

<PAGE>

                  SECOND AMENDMENT TO SECURED PROMISSORY NOTE
                  -------------------------------------------

     This Second Amendment to Secured Promissory Note is made as of the 15/th/
day of December, 1999.

     Reference is hereby made to that certain Secured Promissory Note dated June
17, 1996 from Doros Platika (the "Maker") in favor of Ontogeny, Inc. (the
"Company") in the original principal amount of $500,000.00, as amended by a
First Amendment to Secured Promissory Note dated August 31, 1998 (collectively,
the "Note").

     WHEREAS, the Maker and the Company wish to amend the Note on the terms and
conditions hereinafter set forth.

     NOW, THEREFORE, for good and valuable consideration the receipt and
sufficiency of which are hereby acknowledged, the Maker and the Company hereby
agree that the Note is amended as follows:

     1.   The fourth paragraph of the Note (beginning "Payment of this Note") is
hereby deleted and replaced with the following:

     "Payment of this Note is secured by a mortgage dated December __, 1999 from
     the Maker and Patricia C. Platika to the Company (the "Mortgage").

     2.   Except as hereby amended, the Note remains in full force and effect
and the parties hereto ratify and confirm the same.

     EXECUTED as a sealed instrument as of the date first above written.

                                             MAKER:

                                             /s/ Doros Platika
                                             -------------------------------
                                             Doros Platika

                                             COMPANY:

                                             ONTOGENY, INC.

                                             By: /s/ George A. Eldridge
                                                ----------------------------
                                                     George A. Eldridge
                                                     Vice President Finance

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00010-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00010-of-00352.parquet"}]]