Document:

Ex-10.1

 

Exhibit
10.1

CREDIT AGREEMENT

     This
Credit Agreement (“Agreement”) is made as of
March 1, 2007, by and between
LUMINEX CORPORATION (“Borrower”), a Delaware corporation, and JPMORGAN CHASE BANK, N.A.
(“Lender”), a national banking association. Borrower has requested that Lender make loans
to Borrower in the following manner and subject to the following terms and conditions:

ARTICLE I

Definitions

     Section 1.01 Certain Definitions. Unless a particular word or phrase is otherwise
defined or the context otherwise requires, capitalized words and phrases used in this Agreement
shall have the following meanings (all definitions that are defined in this Agreement in the
singular to have the same meanings when used in the plural and vice versa):

     Accounts shall have the meaning set forth in Article 9 of the UCC.

     Adjusted LIBOR Rate shall mean, with respect to any LIBOR Borrowing for any Interest
Period, an interest rate per annum (rounded upwards, if necessary, to the next 1/16 of 1%) equal to
the sum of (a) the product of (i) the LIBOR Rate in effect for such Interest Period and (ii)
Statutory Reserves, and (b) 1.75% (computed on the basis of the actual number of days elapsed over
a 360-day year).

     Affiliate means any Person controlling, controlled by or under common control with any
other Person. For purposes of this definition, “control” (including “controlled
by” and “under common control with”) means the possession, directly or indirectly, of
the power to direct or cause the direction of the management and policies of such Person, whether
through the ownership of any indicia of equity rights (whether issued and outstanding capital
stock, partnership interests or otherwise) or by any other means.

     Agreement means this Credit Agreement, as it may from time to time be amended,
modified, restated or supplemented.

     Alternate Base Rate means, for any day, a rate per annum equal to the greater of (a)
the Prime Rate in effect on such day minus 1.00%, and (b) the Federal Funds Effective Rate in
effect on such day plus 1/2 of 1%. Any change in the Alternate Base Rate due to a change in the
Prime Rate or the Federal Funds Effective Rate shall be effective from and including the effective
date of such change in the Prime Rate or the Federal Funds Effective Rate, respectively.

     Alternate Base Rate Borrowing shall mean, as of any date, that portion of the
principal balance of the Loans bearing interest at the Alternate Base Rate as of such date.

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     Annual Audited Financial Statements means (a) the annual audited consolidated
financial statements of Borrower and its Subsidiaries, including all notes thereto, which
statements shall include a balance sheet as of the end of such fiscal year and an income statement,
retained earnings statement and statement of cash flows for such fiscal year, all setting forth in
comparative form the corresponding figures from the previous fiscal year, all prepared in
conformity with GAAP, and without expressing any doubt as to Borrower’s ability to continue as a
going concern, and accompanied by a report and opinion of independent certified public accountants
of recognized standing satisfactory to Lender, which shall state that such financial statements, in
the opinion of such accountants, present fairly, in all material respects, the consolidated
financial position of Borrower and its Subsidiaries as of the date thereof and the results of their
operations for the period covered thereby in conformity with GAAP, and (b) the annual consolidating
financial statements of the Borrower and its Subsidiaries, if any, containing a balance sheet as of
the end of such fiscal year and a statement of operations for such fiscal year prepared in
reasonable detail. Such statements shall be accompanied by a certificate of such accountants that
in making the appropriate audit and/or investigation in connection with such report and opinion,
such accountants did not become aware of any Default under any of the financial covenants in
Section 5.03 or, if in the opinion of such accountant any such Default under Section
5.03 exists, a description of the nature and status thereof.

     Applicable Lending Office shall mean Lender’s Domestic Lending Office in the case of
an Alternate Base Rate Borrowing and Lender’s LIBOR Lending Office in the case of a LIBOR
Borrowing.

     Bankruptcy Code means the United States Bankruptcy Code, as amended, and any successor
statute.

     Board means the Board of Governors of the Federal Reserve System of the United States
of America and any successor entity performing similar functions.

     Borrowing Authorization means (i) with respect to a corporation, a certificate, in
Proper Form, of the Secretary or an Assistant Secretary of a corporation as to the resolutions of
the Board of Directors of such corporation authorizing the execution, delivery and performance of
the Credit Documents to be executed by such corporation; the incumbency and signature of the
officer of such corporation executing such documents on behalf of such corporation, and the
Organizational Documents of such corporation, and (ii) with respect to a partnership, limited
liability company, joint venture or other non-individual Person, such written instruments as shall
be required by Lender, each in Proper Form, authorizing the execution, delivery and performance of
the Credit Documents to be executed by such Person; the incumbency and signature of the
representative of such Person executing such documents on behalf of such Person, and the
Organizational Documents of such Person.

     Borrowing Base means, as at any date, the amount of the Borrowing Base shown on the
Borrowing Base Certificate then most recently delivered pursuant to Paragraph 5.02(c)
hereof, determined by calculating the amount equal to the sum of the following:

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	 	(a)	 	80% of the Eligible Accounts of Borrower and its wholly-owned Domestic
Subsidiaries at said date; and
	 
	 	(b)	 	the lesser of (i) 50% of the Eligible Inventory of Borrower and its
wholly-owned Domestic Subsidiaries at said date or (ii) $2,000,000.00.

In the absence of a current Borrowing Base Certificate, Lender may determine the Borrowing Base
from time to time in its reasonable discretion, taking into account all information reasonably
available to it, and the Borrowing Base from time to time so determined shall be the Borrowing Base
for all purposes of this Agreement until a current Borrowing Base Certificate, in Proper Form, is
furnished to and accepted by Lender. Notwithstanding any provision to the contrary in this
Agreement or in any other Credit Document, if any collateral audit or field exam of Borrower’s
and/or any of its Domestic Subsidiaries’ operations and Collateral by Lender (a) discloses any
material deviations for the applicable Borrowing Base components reported under the most recently
delivered Borrowing Base Certificate, then the applicable Borrowing Base components for which such
deviations are discovered may be adjusted accordingly at Lender’s reasonable discretion, or (b)
results in material negative adjustments when compared to the results from the initial collateral
audit or field exam of Borrower’s operations and Collateral conducted by Lender prior to the date
of this Agreement, then the Borrowing Base components and features (i.e., eligibility criteria,
Borrowing Base advance rates and/or dollar ceilings, if applicable) may be adjusted accordingly at
Lender’s reasonable discretion.

     Borrowing Base Certificate means a certificate, duly executed by an appropriate
officer or other responsible party acceptable to Lender on behalf of Borrower, appropriately
completed and in substantially the form of Exhibit C hereto. Each Borrowing Base
Certificate shall be effective only as accepted by Lender (and with such revisions, if any, as
Lender may require as a condition to such acceptance).

     Business Day means a day (other than a Saturday or Sunday) on which banks generally
are open in Austin, Chicago and Dallas for the conduct of substantially all of their commercial
lending activities and interbank wire transfers can be made on the Fedwire system;
provided, however, that with respect to LIBOR Borrowings, Business Day shall also
mean a day on which transactions in dollar deposits between lenders may be carried on in the London
eurodollar interbank market.

     Capital Expenditures means, as to any Person, expenditures in respect of fixed or
capital assets by such Person, including the capital portion of lease payments made in respect of
Capital Lease Obligations, but excluding expenditures for the restoration, repair or
replacement of any fixed or capital asset which was destroyed or damaged, in whole or in part, to
the extent financed by the proceeds of an insurance policy maintained by such Person or other
proceeds related thereto. Expenditures in respect of replacements and maintenance consistent with
the business practices of a Person in respect of plant facilities, machinery, fixtures and other
like capital assets utilized in the ordinary course of business are not Capital Expenditures to the
extent such expenditures are not capitalized in preparing a balance sheet of such Person in
accordance with GAAP.

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     Capital Lease Obligations means, as to any Person, the obligations of such Person to
pay rent or other amounts under a lease of (or other agreement conveying the right to use) real
and/or personal Property which obligations are required to be classified and accounted for as a
capital lease on a balance sheet of such Person under GAAP (including Statement of Financial
Accounting Standards No. 13 of the Financial Accounting Standards Board, as amended) and, for
purposes of this Agreement, the amount of such obligations shall be the capitalized amount thereof,
determined in accordance with GAAP (including such Statement No. 13).

     Cash Equivalents means:

     (a) readily marketable securities issued or fully guaranteed by the United States of
America with maturities of not more than one year;

     (b) commercial paper rated “Prime 1” by Moody’s Investors Service, Inc. or “A-1” by
Standard and Poor’s Corporation with maturities of not more than 180 days;

     (c) certificates of deposit or repurchase obligations issued by any U.S. domestic bank
having capital surplus of at least $100,000,000 or by any other financial institution
acceptable to Lender, all of the foregoing not having a maturity of more than one year from
the date of issuance thereof;

     (d) fully collateralized repurchase agreements with a term of not more than 30 days for
securities described in clause (a) above and entered into with a financial
institution satisfying the criteria described in clause (c) above; and

     (e) money market funds that (i) comply with the criteria set forth in SEC Rule 2a-7
under the Investment Company Act of 1940, (ii) are rated A2 by Standard & Poor’s Ratings
Group or P2 by Moody’s Investors Service, Inc., and (iii) have portfolio assets of at least
$250,000,000.

     Ceiling Rate means, on any day, the maximum nonusurious rate of interest permitted for
that day by whichever of applicable federal or Texas laws permits the higher interest rate, stated
as a rate per annum. On each day, if any, that the Texas Finance Code establishes the Ceiling
Rate, the Ceiling Rate shall be the “weekly ceiling” (as defined in the Texas Finance Code) for
that day. Lender may from time to time, as to current and future balances, implement any other
ceiling under the Texas Finance Code by notice to Borrower, if and to the extent permitted by the
Texas Finance Code. Without notice to Borrower or any other person or entity, the Ceiling Rate
shall automatically fluctuate upward and downward as and in the amount by which such maximum
nonusurious rate of interest permitted by applicable law fluctuates.

     Change in Law means (a) the adoption of any law, rule or regulation after the date of
this Agreement, (b) any change in any law, rule or regulation or in the interpretation or
application thereof by any Governmental Authority after the date of this Agreement or (c)
compliance by Lender (or, for purposes of Section 2.07(a), by any lending office of Lender
or by Lender’s

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holding company) with any binding request, guideline or directive (whether or not
having the force of law) of any Governmental Authority made or issued after the date of this
Agreement.

     Code means the Internal Revenue Code of 1986, as amended, as now or hereafter in
effect, together with all regulations, rulings and interpretations thereof or thereunder by the
Internal Revenue Service.

     Collateral means all Property, tangible or intangible, real, personal or mixed, now or
hereafter subject to any Security Documents, including without limitation, (a) at all times, all
Accounts, Equipment, Inventory and General Intangibles and other related property and proceeds
thereof, now or hereafter owned by Borrower and/or any of its wholly-owned Domestic Subsidiaries,
excluding all copyrights, trademarks, tradenames, patents and other similar intellectual property,
and (b) that certain note receivable executed or to be executed by TM Bioscience Corporation,
payable to the order of Borrower in the original principal amount of $15,000,000.00, evidencing the
aggregate outstanding balance of all cash invested or loaned by Borrower or any of its Domestic
Subsidiaries to TM Bioscience Corporation, together with any renewal, extension, increase,
amendment, modification, restatement or supplement of such promissory note.

     Collateral Access Agreement means any landlord waiver, subordination or other
agreement, in form and substance satisfactory to Lender, between Lender and any third party
(including any licensor, bailee, consignee, customs broker, or other similar Person) in possession
of any Collateral or any landlord of Borrower or any of its Domestic Subsidiaries for any real
property where any Collateral is located, as such landlord waiver, subordination or other agreement
may be amended, restated, or otherwise modified from time to time.

     Commitment means the obligation, if any, of Lender to make Loans to the Borrower in an
aggregate principal amount at any one time outstanding up to (but not exceeding) $15,000,000.00, as
such amount may be adjusted from time to time pursuant to other provisions of this Agreement.

     Compliance Certificate shall have the meaning given to it in Section 5.02(c)
hereof.

     Consequential Loss shall mean, any amounts payable under Section 2.06(d).

     Controlled Group means all members of a controlled group of corporations and all
trades or businesses (whether or not incorporated) under common control which, together with the
applicable Person, are treated as a single employer under Section 414 of the Code.

     Credit Documents means any and all papers now or hereafter governing, evidencing,
guaranteeing or securing or otherwise relating to all or any part of the Obligations, including the
Note, this Agreement, Borrowing Authorizations with respect to all such Persons as Lender may
require, the Security Documents, all instruments, certificates and agreements now or hereafter
executed or delivered to Lender pursuant to any of the foregoing or in connection with the Loans or

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any commitment regarding the Loans, including without limitation, any International Swaps and
Derivatives Association, Inc. (ISDA) Master Agreement or any similar or other agreement with
respect to any Rate Management Transaction, and all amendments, modifications, renewals,
extensions, increases and rearrangements of, and substitutions for, any of the foregoing.

     Default means an Event of Default or an event which with notice or lapse of time or
both would, unless cured or waived, become an Event of Default.

     Default Rate means, on any day, a rate per annum equal to the Ceiling Rate for that
day, or only if applicable law imposes no maximum nonusurious rate of interest for that day, then
the Default Rate for that day shall be a rate per annum equal to 18% per annum.

     Dollars or $ refers to lawful money of the United States of America.

     Domestic Lending Office shall mean the office of Lender specified in the address
portion on the signature pages hereof, or such other office of Lender as Lender may from time to
time specify to the Borrower as its “Domestic Lending Office.”

     Domestic Subsidiary shall mean any Subsidiary of that is organized and domiciled in
the Unites States of America.

     Eligible Accounts means, as at any date of determination thereof, each Account which
is at said date payable to Borrower or any of its wholly-owned Domestic Subsidiaries and which
complies with the following requirements:

	 	(a)	 	all payments due on the Account have been billed and invoiced in a timely
fashion and in the normal course of business;
	 
	 	(b)	 	no payment on the Account is more than 90 days past the date of invoice;
	 
	 	(c)	 	the Account has been created by Borrower or its applicable wholly-owned
Domestic Subsidiary in the ordinary course of business from a completed, outright and
lawful sale of goods, to which such goods have been shipped and title has passed to the
applicable account debtor on an absolute sales basis, or from the rendering of services
by or on behalf of Borrower or such Domestic Subsidiary and is deemed “earned” under
the applicable service contract or other agreement between the applicable account
debtor and Borrower or such Domestic Subsidiary;
	 
	 	(d)	 	the Account is Collateral hereunder and is subject to a first priority
perfected Lien in favor of the Lender and is free and clear of all other Liens of any
nature whatsoever (except for Permitted Encumbrances);

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	(e)	 	twenty percent (20%) or less of all billed Accounts owing by the applicable
account debtor to Borrower and its wholly-owned Domestic Subsidiaries are more than 120
days past the date of invoice;
	 
	(f)	 	the Account, together with all other Accounts owing from the applicable debtor
and its Affiliates to Borrower and its wholly-owned Domestic Subsidiaries, is not in
excess of twenty percent (20%) of the aggregate amount of all Accounts then owing to
Borrower and its wholly-owned Domestic Subsidiaries by all account debtors (it being
agreed that for purposes of this subparagraph, only the aggregate amount of such
Accounts owing from the applicable debtor and its Affiliates in excess of such 20%
concentration threshold shall be excluded from Eligible Accounts); provided,
however, that the foregoing concentration limit shall be fifty percent (50%),
and not twenty percent (20%), with respect to (1) Accounts owing from One Lambda
Incorporated and its Affiliates to Borrower and its wholly-owned Domestic Subsidiaries
and (2) Accounts owing from Bio-Rad Laboratories, Inc. to Borrower and its wholly-owned
Domestic Subsidiaries;
	 
	(g)	 	the Account does not arise out of a bill-and-hold, guaranteed sale,
sale-and-return, consignment, sale-on-approval, progress billing, promotional
(including samples), C.O.D. or cash in advance arrangement;
	 
	(h)	 	the Account is not subject to any setoff, contra, offset, deduction, dispute,
charge back, credit, counterclaim or other defense arising out of the transactions
represented by the Account or independently thereof (but in each case regarding an
undisputed liquidated sum, only to the extent of such undisputed sum, and in each case
regarding a disputed sum or claim, only to the extent of the sum or amount claimed by
the party adverse to Borrower or its applicable wholly-owned Domestic Subsidiary);
	 
	(i)	 	the applicable account debtor has finally accepted the goods or services from
the sale out of which the Account arose and has not (1) objected to such account
debtor’s liability thereon, (2) rejected any of such services or goods or (3) returned
or repossessed any of such goods, except for goods returned in the ordinary course of
business for which, in the case of goods returned, goods of equal or greater value have
been shipped in return;
	 
	(j)	 	the Account must not be “performance” related and subject to future adjustment;
	 
	(k)	 	the applicable account debtor is not any Governmental Authority;
	 
	(l)	 	the applicable account debtor is not a director, officer, employee or any
Affiliate of Borrower or any of its Subsidiaries;

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	 	(m)	 	the applicable account debtor must not be a natural Person and must be
organized under the laws of any state or province, or have its principal place of
business located within the United States or Canada;
	 
	 	(o)	 	the Account is not evidenced by a promissory note or other instrument or by
chattel paper;
	 
	 	(p)	 	the Account complies with all material Legal Requirements (including without
limitation, all usury laws, fair credit reporting and billing laws, fair debt
collection practices and rules, and regulations relating to truth in lending and other
similar matters);
	 
	 	(q)	 	the Account is in full force and effect and constitutes a legal, valid and
binding obligation of the applicable account debtor enforceable in accordance with the
terms thereof;
	 
	 	(r)	 	the Account is denominated in and provides for payment by the applicable
account debtor in U.S. dollars or Canadian dollars (with the Borrower being required to
report for Borrowing Base purposes the U.S. dollar equivalent amount of Canadian dollar
denominated Accounts, and in determining the Borrowing Base for any purpose, Lender
shall be entitled at any time to redetermine at any time the U.S. dollar equivalent of
Canadian dollar denominated Accounts based upon the most recent applicable information
then available to Lender);
	 
	 	(s)	 	the Account has not been and is not required to be charged or written off as
uncollectible in accordance with GAAP; and
	 
	 	(t)	 	except for Accounts fully backed by a letter of credit in all respects
acceptable to the Lender in its discretion, the credit standing of the applicable
account debtor in relation to the amount of credit extended has not become
unsatisfactory, as reasonably determined by Lender.

Additionally, in calculating Eligible Accounts, each of the following shall be excluded (to the
extent the same are otherwise included in Eligible Accounts): (i) unpaid sales, excise or similar
taxes owed by Borrower and/or any of its wholly-owned Domestic Subsidiaries; and (ii) returns,
discounts, claims, credits and allowances of any nature asserted or taken by account debtors of
Borrower and/or any of its wholly-owned Domestic Subsidiaries. Nothing in this definition of
“Eligible Accounts” shall be construed to limit or release any right of Lender to any
Collateral.

     Eligible Inventory means, as at any date of determination thereof, any Inventory of
any Borrower or any of its wholly-owned Domestic Subsidiaries and which complies with the following
requirements:

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	(a)	 	good title to such Inventory is owned by and recorded on the books and records
of Borrower or its applicable wholly-owned Domestic Subsidiary in the ordinary course
of business;
	 
	(b)	 	such Inventory is only raw materials and does not include any finished goods or
work-in-progress Inventory, is not scrap or remnants Inventory and is not display items
or manufacturing, replacement, packaging or shipping supplies or materials;
	 
	(c)	 	such Inventory is valued in accordance with GAAP on a “standard cost” basis at
the lower of fair market value or cost;
	 
	(d)	 	such Inventory is Collateral hereunder and is subject to a first priority
perfected Lien in favor of the Lender and is free and clear of all other Liens of any
nature whatsoever (except for Permitted Encumbrances);
	 
	(e)	 	such Inventory meets all applicable laws and standards imposed by any
Governmental Authority having regulatory authority over it;
	 
	(f)	 	such Inventory must not be in transit and must be housed or stored in the
United States at a real Property location either owned or leased by Borrower or any of
its wholly-owned Domestic Subsidiaries or a public warehouse facility utilized by
Borrower or any of its wholly-owned Domestic Subsidiaries, so long as such leased
facility or public warehouse facility is covered by a Collateral Access Agreement
delivered to the Lender by the lessor or operator thereof;
	 
	(g)	 	such Inventory must be adequately insured to the reasonable satisfaction of the
Lender pursuant to insurance coverage required by this Agreement and the Security
Documents;
	 
	(h)	 	such Inventory has not been sold and must not be on consignment;
	 
	(i)	 	such Inventory is not obsolete or slow moving;
	 
	(j)	 	such Inventory is not manufactured, produced or sold pursuant to any license or
other similar agreement of any patent, trademark or copyright unless the applicable
license or other similar agreement of any patent, trademark or copyright does not
directly or indirectly restrict, in the Lender’s reasonable judgment, the Lender’s
ability to resale such Inventory without further consent of the applicable licensor or
other similar party in the event of foreclosure or other recovery of such Inventory by
the Lender; and
	 
	(k)	 	the Lender has not deemed such Inventory ineligible because the Lender
considers such Inventory in its reasonable discretion to be unmarketable or the value
thereof to be impaired or its ability to realize such value to be insecure in any
material respect.

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Nothing in this definition of “Eligible Inventory” shall be construed to limit or release
any right of Lender to any Collateral.

     Environmental Claim means any third party (including Governmental Authorities and
employees) action, lawsuit, claim or proceeding (including claims or proceedings at common law or
under the Occupational Safety and Health Act or similar laws relating to safety of employees) which
seeks to impose liability for (i) noise; (ii) pollution or contamination of the air, surface water,
ground water or land or the clean-up of such pollution or contamination; (iii) solid, gaseous or
liquid waste generation, handling, treatment, storage, disposal or transportation; (iv) exposure to
Hazardous Substances; (v) the safety or health of employees or (vi) the manufacture, processing,
distribution in commerce or use of Hazardous Substances. An “Environmental Claim” includes
a common law action, as well as a proceeding to issue, modify or terminate an Environmental Permit,
or to adopt or amend a regulation to the extent that such a proceeding attempts to redress
violations of an applicable permit, license, or regulation as alleged by any Governmental
Authority.

     Environmental Liabilities includes all liabilities arising from any Environmental
Claim, Environmental Permit or Requirement of Environmental Law under any theory of recovery, at
law or in equity, and whether based on negligence, strict liability or otherwise, including
remedial, removal, response, abatement, restoration (including natural resources), investigative,
monitoring, personal injury and damage to Property or natural resources or injuries to persons, and
any other related costs, expenses, losses, damages, penalties, fines, liabilities and obligations,
and all costs and expenses necessary to cause the issuance, reissuance or renewal of any
Environmental Permit, including reasonable attorneys’ fees and court costs.

     Environmental Matters means matters relating to pollution or protection of the
environment, including emissions, discharges, releases or threatened releases of Hazardous
Substances into the environment (including ambient air, surface water or ground water, or land
surface or subsurface), or otherwise relating to the manufacture, processing, distribution, use,
treatment, storage, disposal, transport or handling of Hazardous Substances.

     Environmental Permit means any permit, license, approval or other authorization under
any applicable Legal Requirement relating to pollution or protection of health or the environment,
including laws, regulations or other requirements relating to emissions, discharges, releases or
threatened releases of pollutants, contaminants or hazardous substances or toxic materials or
wastes into ambient air, surface water, ground water or land, or otherwise relating to the
manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of
pollutants, contaminants or Hazardous Substances.

     Equipment shall have the meaning set forth in Article 9 of the UCC.

     Equity Interests means shares of the capital stock, partnership interests, membership
interests in a limited liability company, beneficial interests in a trust or other equity ownership
interests in a Person, or any warrants, options or other rights to acquire such interests.

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     ERISA means the Employee Retirement Income Security Act of 1974, as amended from time
to time, and all rules, regulations, rulings and interpretations adopted by the Internal Revenue
Service or the U.S. Department of Labor thereunder.

     Event of Default shall have the meaning assigned to it in Section 7.01 hereof.

     Federal Funds Effective Rate means, for any day, the rate per annum equal to the
weighted average of the rates on overnight Federal funds transactions with members of the Federal
Reserve System arranged by Federal funds brokers on such day, as published by the Federal Reserve
Bank of New York on the Business Day next succeeding such day; but if (a) such day
is not a Business Day, the Federal Funds Effective Rate for such day shall be such rate on such
transactions on the next preceding Business Day as so published on the next succeeding Business
Day, and (b) no such rate is so published on such next succeeding Business Day, the Federal Funds
Rate for such day shall be the average rate (rounded upward, if necessary, to a whole multiple of
1/100 of 1%) charged to Lender on such day on such transactions as determined by Lender.

     Financing Statements means all such Uniform Commercial Code financing statements as
Lender shall reasonably require, in Proper Form, to give notice of and to perfect or continue
perfection of Lender’s Liens in all Collateral.

     Funded Indebtedness means, as to a particular Person at any particular time, without
duplication, the sum of (a) all obligations for borrowed money (whether as a direct obligor on a
promissory note, bond, debenture or other similar instrument, as a reimbursement obligor with
respect to an issued letter of credit or similar instrument, as an obligor under a contingent
obligation in respect of borrowed money, or as any other type of direct or contingent obligor), and
(b) all Capital Lease Obligations (other than the interest component of such obligations),
calculated without duplication, on a consolidated basis and in accordance with GAAP.

     GAAP means, as to a particular Person, such accounting practice as, in the opinion of
the independent certified public accountants of recognized national standing regularly retained by
such Person and acceptable to Lender, conforms at the time to generally accepted accounting
principles, consistently applied. GAAP means those principles and practices (a) which are
recognized as such by the Financial Accounting Standards Board, (b) which are applied for all
periods after the date hereof in a manner consistent with the manner in which such principles and
practices were applied to the most recent audited financial statements of the relevant Person
furnished to Lender, and (c) which are consistently applied for all periods after the date hereof
so as to reflect properly the financial condition, and results of operations and changes in
financial position, of such Person. If any change in any accounting principle or practice is
required by the Financial Accounting Standards Board in order for such principle or practice to
continue as a GAAP or practice, all reports and financial statements required hereunder may be
prepared in accordance with such change only after written notice of such change is given to
Lender.

     General Intangibles shall have the meaning set forth in Article 9 of the UCC.

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     Governmental Authority means any foreign governmental authority, the United States of
America, any State of the United States and any political subdivision of any of the foregoing, and
any central bank, agency, department, commission, board, bureau, court or other tribunal having
jurisdiction over Lender, Borrower, any other Obligor or their respective Property.

     Guaranty shall mean (a) that certain Guaranty of even date herewith, executed by
Luminex International Corporation, a Delaware corporation, and Luminex Project, Inc., a Delaware
corporation, in favor of Lender, and (b) each and every other guaranty of the Obligations from time
to time executed and delivered to Lender after the date hereof by any Domestic Subsidiary of
Borrower, as each of the same may be amended, supplemented, modified, joined in pursuant to a
Joinder Agreement and restated from time to time.

     Hazardous Substance shall mean petroleum products and any hazardous or toxic waste or
substance defined or regulated as a hazardous substance from time to time by any law, rule,
regulation or order described in the definition of “Requirements of Environmental Law”.

     Indebtedness means and includes (a) all items which in accordance with GAAP would be
included on the liability side of a balance sheet on the date as of which Indebtedness is to be
determined (including the principal component of any Capital Lease Obligations, but excluding
capital stock, surplus, surplus reserves and deferred credits); (b) all guaranties, letter of
credit contingent reimbursement obligations, endorsements and other contingent obligations in
respect of, or any obligations to purchase or otherwise acquire, Indebtedness of others, and (c)
all Indebtedness secured by any Lien existing on any interest of the Person with respect to which
Indebtedness is being determined in Property owned subject to such Lien whether or not the
Indebtedness secured thereby shall have been assumed; provided, that such term shall not
mean or include any Indebtedness in respect of which monies sufficient to pay and discharge the
same in full (either on the expressed date of maturity thereof or on such earlier date as such
Indebtedness may be duly called for redemption and payment) shall be deposited with a depository,
agency or trustee acceptable to Lender in trust for the payment thereof.

     Interest Expense means, for any Person during any applicable period, the total
interest expense accruing on Indebtedness of such Person and/or its Subsidiaries, on a consolidated
basis, during such period (including interest expense attributable to Capitalized Lease Obligations
and amounts, both positive and negative, attributable to interest expense incurred under any Rate
Management Transaction), computed and calculated, without duplication, in accordance with GAAP.

     Interest Option shall have the meaning specified in Section 2.05(a) hereof.

     Interest Payment Date means (a) for Alternate Base Rate Borrowings, the first day of
each June, September, December and March; and (b) for LIBOR Borrowings, the end of the Interest
Period applicable to such LIBOR Borrowing.

     Interest Period shall mean the period commencing on the date of the applicable LIBOR
Borrowing and ending on the numerically corresponding day (or, if there is no numerically

12

 

corresponding day, on the last day) in the calendar month that is one (1), two (2) or three
(3) months thereafter, as Borrower may elect in accordance herewith; provided,
however, that (a) if an Interest Period would end on a day that is not a Business Day, such
Interest Period shall be extended to the next succeeding Business Day, unless such next succeeding
Business Day would fall in the next calendar month, in which case such Interest Period shall end on
the next preceding Business Day, (b) no Interest Period shall end later than the Maturity Date for
any portion of the Loans that are LIBOR Borrowings, and (c) interest shall accrue from and
including the first day of an Interest Period to, but excluding, the last day of such Interest
Period.

     Inventory shall have the meaning set forth in Article 9 of the UCC.

     Investment means the purchase or other acquisition of any securities or Indebtedness
of, or the making of any loan, advance, transfer of Property or capital contribution to, or the
incurring of any liability, contingently or otherwise, in respect of the Indebtedness of, any
Person.

     Joinder Agreement shall mean any agreement, in Proper Form, executed by a Domestic
Subsidiary of Borrower from time to time after the date hereof in accordance with Section
6.08 hereof, pursuant to which such Subsidiary joins in the execution and delivery of a
Guaranty and the applicable Security Documents.

     Legal Requirement means any law, statute, ordinance, decree, requirement, order,
judgment, rule, or regulation (or interpretation of any of the foregoing) of, and the terms of any
license or permit issued by, any Governmental Authority, whether presently existing or arising in
the future. The term “Legal Requirement” includes Requirements of Environmental Law.

     LIBOR Borrowing shall mean, as of any date, that portion of the principal balance of
the Loans bearing interest at the Adjusted LIBOR Rate as of such date.

     LIBOR Lending Office shall mean the office of Lender specified in the address portion
on the signature pages hereof, or such other office of Lender as Lender may from time to time
specify in writing to the Borrower as its LIBOR Lending Office.

     LIBOR Rate shall mean, with respect to any LIBOR Borrowing for any Interest Period, an
interest rate per annum equal to the rate appearing on Page 3750 of the Dow Jones Telerate Service
(or if no longer available on any successor or substitute page of such Service, or any successor to
or substitute for such Service, providing rate quotations comparable to those currently provided on
such page of such Service, as determined by Lender from time to time for purposes of providing
quotations of interest rates applicable to dollar deposits in the London interbank market) at
approximately 11:00 a.m., London time, two Business Days before the commencement of such Interest
Period for a maturity equal to the applicable Interest Period. In the event that such rate is not
available at such time for any reason, then the “LIBOR Rate” with respect to such LIBOR Borrowing
for such Interest Period shall be the interest rate per annum (rounded upwards, if necessary, to
the next 1/16 of 1%) equal to the rate at which dollar deposits approximately equal in principal
amount to such LIBOR Borrowing and for a maturity equal to the applicable Interest Period are
offered in by the principal London office of Lender in

13

 

immediately available funds in the London interbank market at approximately 11:00 a.m., London
time, two Business Days before the commencement of such Interest Period.

     Lien means any mortgage, pledge, charge, encumbrance, security interest, collateral
assignment or other lien or restriction of any kind, whether based on common law, constitutional
provision, statute or contract, and shall include reservations, exceptions, encroachments,
easements, rights of way, covenants, conditions, restrictions, leases and other title exceptions.

     Loans means the loans described in and provided for by Section 2.01.

     Material Adverse Effect shall mean a material adverse effect on (a) the business,
assets, property, or condition (financial or otherwise) of Obligors, taken as a whole, which in
Lender’s reasonable judgment, impairs or could reasonably be expected to impair Lender’s ability in
any material respect to collect the Obligations when due, or (b) the validity or enforceability of
the Agent’s Lien on any material portion of the Collateral or the priority of such Lien.

     Marketable Securities means publicly-registered marketable securities that (a) are
readily tradable on a nationally-recognized public exchange, (b) do not constitute Cash
Equivalents, and (c) have a fair market value that is readily determinable and available on any
Business Day.

     Maturity Date means the earlier to occur of (a) 364 days after the date of this
Agreement, (b) any date that the Commitment is terminated in full by Borrower pursuant to
Section 2.01(c) hereof, and (c) any date the Maturity Date is accelerated or the Commitment
is terminated by Lender pursuant to Section 7.02 hereof.

     Note means the promissory note dated concurrently herewith executed by Borrower
payable to the order of Lender in the face amount of $15,000,000.00, and any and all renewals,
extensions, modifications, rearrangements and/or replacements thereof.

     Obligations means the Indebtedness evidenced by the Note and other sums now or
hereafter payable to Lender by Borrower or any other Obligor under any of the Credit Documents,
including all obligations, contingent or otherwise, whether now or hereafter arising under any Rate
Management Transaction, together with performance of all other obligations, liabilities and
Indebtedness of Borrower to Lender under any one or more of the Credit Documents, including all
fees, costs, expenses and indemnity obligations under this Agreement and all other Credit
Documents.

     Obligors means Borrower and each of its Domestic Subsidiaries now or hereafter
primarily or secondarily obligated to pay to Lender all of the Obligations.

     Organizational Documents means, with respect to a corporation, the certificate of
incorporation, articles of incorporation and bylaws of such corporation; with respect to a
partnership, the partnership agreement establishing such partnership; with respect to a limited
liability company, the articles of organization or formation and regulations or operating agreement
of such limited liability company; with respect to a joint venture, the joint venture agreement

14

 

establishing such joint venture, and with respect to a trust, the instrument establishing such
trust; in each case including any and all modifications thereof as of the date of the Credit
Document referring to such Organizational Document and any and all future modifications thereof
which are consented to by Lender.

     Parties means all Persons other than Lender executing any Credit Document.

     PBGC means the Pension Benefit Guaranty Corporation or any entity succeeding to any or
all of its functions under ERISA.

     Permitted Acquisition means (a) the TMB Acquisition, so long as the TMB Acquisition is
consummated in compliance with all material terms of the TMB Acquisition Agreement and immediately
after the actual consummation thereof, (i) the actual consolidated balance sheet for Borrower
(including the financial information for TM Bioscience Corporation) and the actual funds
flow/sources and uses statement for the TMB Acquisition are both consistent in all material
respects with the pro-forma consolidated balance sheet and funds flow/sources and uses statement
furnished to Lender under the terms of Section 3.02(i), and (ii) the aggregate amount of
all cash, Cash Equivalents and Marketable Securities held by the Borrower as of the date of
consummation of the TMB Acquisition and that is unencumbered, unrestricted and not subject to any
Liens (other than Permitted Encumbrances) is equal to or greater than the sum of (1) the aggregate
amount of Funded Indebtedness owing as of such date by Borrower and TM Bioscience Corporation
(excluding up to $4,000,000 of Indebtedness then owing to any Canadian Governmental Authority), and
(2) $10,000,000, and (b) any other acquisition by an Obligor of all or substantially all of the
assets of a Person, of all or substantially all of any business or division of a Person or of 100%
of the Equity Interests of a Person (upon merger or otherwise), in each case to the extent that (i)
Lender receives not less than thirty (30) days prior written notice of such acquisition, (ii) after
giving effect to such acquisition, and without giving effect to any projected cost savings after
the applicable acquisition, no Default or Event of Default shall exist and Borrower shall be in
compliance with the financial covenants set forth in Section 5.03 hereof, (iii) the
aggregate consideration paid in connection with the acquisition shall not exceed $2,000,000 and the
aggregate consideration paid in connection with all such acquisitions shall not exceed $5,000,000,
and (iv) in the case of a proposed merger only, Lender consents in writing to such acquisition
based upon a review of the contingent obligations of such Person (such consent of Lender to not be
unreasonably withheld, conditioned or delayed).

     Permitted Encumbrances means:

     (a) Liens for taxes, assessments or other governmental charges or levies which are not
delinquent or which are being contested in good faith by appropriate action and for which
adequate reserves have been maintained in accordance with GAAP;

     (b) Liens in connection with workers’ compensation, unemployment insurance or other
social security, old age pension or public liability obligations which are not overdue by
more than 30 days or which are being contested in good faith by

15

 

appropriate action and for which adequate reserves have been maintained in accordance with
GAAP;

     (c) statutory landlord’s liens, operators’, vendors’, carriers’, warehousemen’s,
repairmen’s, mechanics’, suppliers’, workers’, materialmen’s, construction or other like
Liens arising by operation of law in the ordinary course of business or incident to the
exploration, development, operation and maintenance of oil and gas properties each of which
is in respect of obligations that are not overdue by more than 30 days or which are being
contested in good faith by appropriate action and for which adequate reserves have been
maintained in accordance with GAAP;

     (d) easements, restrictions, servitudes, permits, conditions, covenants, exceptions or
reservations in any property of Borrower that do not secure any monetary obligations and
which in the aggregate do not materially impair the use of such property for the purposes of
which such property is held by Borrower or materially impair the value of such property
subject thereto;

     (e) judgment and attachment Liens not giving rise to an Event of Default, if
any appropriate legal proceedings which may have been duly initiated for the review of such
judgment shall not have been finally terminated or the period within which such proceeding
may be initiated shall not have expired and no action to enforce such Lien has been
commenced; and

     (f) Liens consisting of bankers’ liens and rights of setoff with respect to any cash,
Cash Equivalent or Marketable Securities accounts, but only to the extent permitted under
the applicable deposit or investment account agreement.

     Person means any individual, corporation, partnership, joint venture, joint stock
association, business or other trust, unincorporated organization, Governmental Authority or any
other form of entity.

     Plan means an employee pension benefit plan which is covered by Title IV of ERISA or
subject to the minimum funding standards under Section 412 of the Code and is either (a) maintained
by Borrower, any of its Subsidiaries or any member of a Controlled Group for employees of Borrower
or any of its Subsidiaries or (b) maintained pursuant to a collective bargaining agreement or any
other arrangement under which more than one employer makes contributions and to which Borrower, any
of its Subsidiaries or any member of a Controlled Group for employees of Borrower or any of its
Subsidiaries is then making or accruing an obligation to make contributions or has within the
preceding five plan years made contributions.

     Prime Rate means, on any day, the rate determined by Lender as being its prime rate
for that day, whether otherwise published or announced. Without notice to Borrower or any other
Person, the Prime Rate shall automatically fluctuate upward and downward as and in the amount by
which said prime rate fluctuates, with each change to be effective as of the date of each change in
said prime rate. THE PRIME RATE IS A REFERENCE RATE AND DOES NOT NECESSARILY

16

 

REPRESENT THE LOWEST OR BEST RATE ACTUALLY CHARGED TO ANY CUSTOMER, AND LENDER DISCLAIMS ANY
STATEMENT, REPRESENTATION OR WARRANTY TO THE CONTRARY. LENDER MAY MAKE COMMERCIAL LOANS OR OTHER
LOANS AT RATES OF INTEREST AT, ABOVE OR BELOW THE PRIME RATE.

     Proper Form means in form and substance reasonably satisfactory to Lender.

     Property means any interest in any kind of property or asset, whether real, personal
or mixed, tangible or intangible.

     Quarterly Financial Statements means the quarterly financial statements of the
Borrower and its Subsidiaries, including all notes thereto, which statements shall include a
balance sheet as of the end of such fiscal quarter and an income statement, retained earnings
statements and a statement of cash flows for such fiscal quarter, and for the fiscal year to date,
subject to normal year-end adjustments, all setting forth in comparative form the corresponding
figures for the corresponding period of the preceding year, prepared on a consolidated and
consolidating basis in accordance with GAAP and certified as true and correct by an authorized
officer of Borrower acceptable to Lender on behalf of Borrower, with the parties recognizing that
such consolidating statements will be prepared in accordance with GAAP only to the extent normal
and customary and shall not be required until the end of the first full fiscal quarter of Borrower
occurring after the consummation of the TMB Acquisition.

     Rate Management Transaction shall mean any transaction (including any International
Swaps and Derivatives Association, Inc. (ISDA) Master Agreement or any similar or other agreement
with respect thereto) now existing or hereafter entered into among Borrower or Lender, JPMorgan
Chase & Co., or any of its subsidiaries or affiliates or their successors which is a rate swap,
basis swap, forward rate transaction, commodity swap, commodity option, equity or equity index
swap, equity or equity index option, bond option, interest rate option, foreign exchange
transaction, cap transaction, floor transaction, collar transaction, forward transaction, currency
swap transaction, cross-currency rate swap transaction, currency option or any other similar
transaction (including any option with respect to any of these transactions) or any combination
thereof, whether linked to one or more interest rates, foreign currencies, commodity prices, equity
prices or other financial measures.

     Rate Selection Date shall mean that Business Day which is (a) in the case of the
Alternate Base Rate Borrowings, the date of such borrowing, or (b) in the case of LIBOR Borrowings,
the date three (3) Business Days preceding the first day of any proposed Interest Period.

     Rate Selection Notice shall have the meaning specified in Section 2.05(b)(1)
hereof.

     Regulation D shall mean Regulation D of the Board of Governors of the Federal Reserve
System from time to time in effect and shall include any successor or other regulation relating to
reserve requirements applicable to member lenders of the Federal Reserve System.

17

 

     Regulatory Change shall mean, with respect to Lender, any change on or after the date
of this Agreement in any Legal Requirement (including Regulation D) or the adoption or making on or
after such date of any interpretation, directive or request applying to a class of lenders
including Lender under any Legal Requirement (whether or not having the force of law) by any
Governmental Authority charged with the interpretation or administration thereof.

     Request for Loan means a request for a Loan duly executed by an appropriate officer or
other responsible party acceptable to Lender on behalf of Borrower, appropriately completed and
substantially in the form of Exhibit A attached hereto.

     Requirements of Environmental Law means all requirements imposed by any law (including
The Resource Conservation and Recovery Act and The Comprehensive Environmental Response,
Compensation, and Liability Act), rule, regulation or order of any Governmental Authority in effect
at the applicable time which relate to (i) noise; (ii) pollution, protection or clean-up of the
air, surface water, ground water or land; (iii) solid, gaseous or liquid waste generation,
recycling, reclamation, treatment, storage, disposal or transportation; (iv) exposure to Hazardous
Substances; (v) the safety or health of employees or (vi) regulation of the manufacture,
processing, distribution in commerce, use, discharge, release, threatened release, emission or
storage of Hazardous Substances.

     Security Agreements means, collectively, (a) that certain Security Agreement of even
date herewith executed by and between Borrower and Lender, covering all Accounts, Equipment,
Inventory and General Intangibles and other related property and proceeds thereof now or hereafter
owned by Borrower, excluding all copyrights, trademarks, tradenames, patents and other similar
intellectual property of Borrower, (b) that certain Security Agreement of even date herewith
executed by and between the existing Domestic Subsidiaries of Borrower and Lender, covering all
Accounts, Equipment, Inventory and General Intangibles and other related property and proceeds
thereof now or hereafter owned by any Domestic Subsidiary of Borrower that is a party thereto,
excluding all copyrights, trademarks, tradenames, patents and other similar intellectual property
of such Domestic Subsidiaries, (c) any and all other security agreements, pledge agreements,
collateral assignments or other similar documents, if any, hereafter executed in favor of Lender,
as security for the payment or performance of any and/or all of the Obligations, and (d) any
amendment, modification, restatement, supplement or joinder of all or any of the above-described
agreements and assignments.

     Security Documents means, collectively, this Agreement, the Security Agreements, the
Financing Statements and any and all other agreements, deeds of trust, mortgages, chattel
mortgages, security agreements, pledges, guaranties, assignments, subordination agreements,
undertakings and other instruments and Financing Statements now or hereafter executed and delivered
in connection with, or as security for the payment or performance of, any Credit Document, as any
of them may from time to time be amended, modified, restated or supplemented.

     Statutory Reserves shall mean a fraction (expressed as a decimal), the numerator of
which is the number one and the denominator of which is the number one minus the aggregate of the
maximum reserve percentage (including without limitation, any marginal, special, emergency

18

 

or supplemental reserves), expressed as a decimal, established by the Board of Governors of the
Federal Reserve System of the United States to which Lender is subject for eurocurrency funding
(currently referred to as “Eurocurrency Liabilities” in Regulation D of the Board). Such reserve
percentages shall include those imposed pursuant to such Regulation D. Statutory Reserves shall be
adjusted automatically on and as of the effective date of any change in any applicable reserve
percentage. For purposes hereof, LIBOR Borrowings shall be deemed to constitute eurocurrency
funding and to be subject to such reserve requirements without benefit of or credit for proration,
exemptions or offsets that may be available from time to time to Lender under such Regulation D or
any comparable regulation.

     Subordinated Indebtedness means all Indebtedness of Borrower or any of its
wholly-owned Domestic Subsidiaries which has been subordinated on terms and conditions satisfactory
to Lender, in its sole discretion, to all Obligations to Lender. Indebtedness shall not be
considered as “Subordinated Indebtedness” unless and until Lender shall have received copies of the
documentation evidencing or relating to such Indebtedness together with a subordination agreement,
in Proper Form, duly executed by the holder or holders of such Indebtedness and evidencing the
terms and conditions of subordination required by Lender in its discretion.

     Subsidiary means, as to a particular parent Person, any other Person of which 50% or
more of the indicia of equity rights (whether outstanding capital stock, partnership interests or
otherwise) is at the time directly or indirectly owned or held by such parent Person, or by one or
more of its Affiliates.

     Tangible Net Worth shall mean, as of any applicable date of determination, (a) net
book value of all assets of Borrower and its Subsidiaries (excluding patent rights, trademarks,
trade names, franchises, copyrights, licenses, goodwill and all other intangible assets of Borrower
and its Subsidiaries), after all appropriate deductions in accordance with GAAP (including, without
limitation, reserves for doubtful receivables, obsolescence, depreciation and amortization), less
(b) all Indebtedness of Borrower and its Subsidiaries, all determined in accordance with GAAP and
on a consolidated basis.

     TMB Acquisition shall mean the purchase by Borrower, pursuant to the terms of the TMB
Acquisition Agreement, of all of the issued and outstanding Equity Interests of TM Bioscience
Corporation, a Canadian entity, more particularly described in the Acquisition Agreement, so as to
cause TM Bioscience Corporation to be a wholly-owned non-Domestic Subsidiary of Borrower.

     TMB Acquisition Agreement shall mean that certain Merger Agreement dated effective as
of December 14, 2007, by and between TM Bioscience Corporation, a Canadian entity, and Borrower, as
purchaser.

     UCC means the Uniform Commercial Code, as in effect from time to time, of the State of
Texas or of any other state the laws of which are required as a result thereof to be applied in
connection with the attachment, perfection or priority of, or remedies with respect to, Lender’s
Lien on any Collateral.

19

 

     Unfunded Liabilities means, with respect to any Plan, at any time, the amount (if any)
by which (a) the present value of all benefits under such Plan exceeds (b) the fair market value of
all Plan assets allocable to such benefits, all determined as of the then most recent actuarial
valuation report for such Plan, but only to the extent that such excess represents a potential
liability of any member of the applicable Controlled Group to the PBGC regarding a Plan or a Plan
under Title IV of ERISA. With respect to multiemployer Plans, as defined in Section 4001(a)(3) of
ERISA, the term “Unfunded Liabilities” shall also include contingent liability for withdrawal
liability under Section 4201 of ERISA to all multiemployer Plans to which Borrower, any other
Obligor or any member of a Controlled Group for employees of Borrower or any other Obligor
contribute in the event of complete withdrawal from such Plans.

     Section 1.02 Terms Generally. The definitions of terms herein shall apply equally to
the singular and plural forms of the terms defined. Whenever the context may require, any pronoun
shall include the corresponding masculine, feminine and neuter forms. The words “include”,
“includes” and “including” shall be deemed to be followed by the phrase “without limitation”. The
word “will” shall be construed to have the same meaning and effect as the word “shall”. Unless the
context requires otherwise (a) any definition of or reference to any agreement, instrument or other
document herein shall be construed as referring to such agreement, instrument or other document as
from time to time amended, supplemented or otherwise modified (subject to any restrictions on such
amendments, supplements or modifications set forth herein), (b) any reference herein to any Person
shall be construed to include such Person’s successors and assigns, (c) the words “herein”,
“hereof” and “hereunder”, and words of similar import, shall be construed to refer to this
Agreement in its entirety and not to any particular provision hereof, (d) all references herein to
Articles, Sections, Exhibits and Schedules shall be construed to refer to Articles and Sections of,
and Exhibits and Schedules to, this Agreement and (e) the words “asset” and “property” shall be
construed to have the same meaning and effect and to refer to any and all tangible and intangible
assets and properties, including cash, securities, accounts and contract rights

ARTICLE II

Loans; Credit Facility Administration

     Section 2.01 Loans; Commitment. Lender agrees, subject to all of the terms and
conditions of this Agreement, to make Loans to Borrower as follows:

     (a) Prior to the Maturity Date, Lender will make Loans to Borrower in an aggregate
principal amount at any one time outstanding up to but not exceeding the lesser of (i) the
Commitment or (ii) the Borrowing Base. Within the foregoing limits and subject to the terms
and conditions set forth herein, Borrower may borrow, prepay and reborrow Loans prior to the
Maturity Date. Borrower and Lender agree pursuant to Chapter 346 (“Chapter 346”) of
the Texas Finance Code that Chapter 346 (which relates to open-end line of credit revolving
loan accounts) shall not apply to this Agreement, the Note or any Loan obligation hereunder
and that none of this Agreement, the Note nor any Loan obligation hereunder shall be
governed by Chapter 346 or subject to its provisions

20

 

in any manner whatsoever. Loans shall be evidenced by the Note, and Lender shall in no
event be obligated to fund more than one (1) Loan per day. Loan proceeds shall be made
available to Borrower by depositing them in an account designated by Borrower and maintained
with Lender.

     (b) As additional consideration for the Commitment of Lender, Borrower shall pay to
Lender an unused commitment fee from the date of this Agreement until and including the
Maturity Date at a rate per annum equal to 0.125%. Such commitment fee shall be computed
(on the basis of the actual number of days elapsed in a year composed of 360 days) on each
day and shall be based on the excess of (i) the amount of the Commitment for such day over
(ii) the unpaid principal balance of the Note on such day. Such commitment fee shall be
payable quarterly in arrears, (1) on the first day of each June,
September, December and March prior to the Maturity Date and (2) on the Maturity Date. All past due fees payable
under this paragraph shall bear interest at the Default Rate from the date that is five (5)
days after written demand for such payment has been made by Lender to Borrower.

     (c) Upon at least five (5) Business Days’ prior irrevocable written notice to Lender,
Borrower may at any time in whole permanently terminate, or from time to time in part
permanently reduce, the Commitment; provided, however, that the Commitment
shall not be reduced at any time to an amount less than the aggregate principal amount of
all Loans outstanding at such time. Simultaneously with any such termination or reduction
of the Commitment, Borrower shall pay to Lender the commitment fee owing under Section
2.01(b) through and including the date of such termination or reduction on the amount of
the Commitment so terminated or reduced. Each partial reduction of the Commitment shall be
in a minimum of $100,000.00, or an integral multiple of $100,000.00 in excess thereof.

Section 2.02 Repayment of Loans; Evidence of Debt.

     (a) Borrower hereby unconditionally promises to pay to Lender in full the unpaid
principal balance of the Note on the Maturity Date.

     (b) Lender shall maintain accounts in which it shall record (i) the amount of each Loan
made hereunder, and (ii) the amount of any principal or interest due and payable or to
become due and payable from Borrower to Lender hereunder. The entries made in such accounts
shall be prima facie evidence of the existence and amounts of the
Obligations recorded therein; but the failure of Lender to maintain such accounts or
any error therein shall not in any manner affect the obligation of Borrower to repay the
Loans in accordance with the terms of this Agreement and the Note.

Section 2.03 Prepayments of Loans.

     (a) Borrower shall have the right at any time and from time to time to prepay any Loan
in whole or in part, without premium or penalty, except as otherwise provided in this
Section 2.03 and subsections (a), (b) or (c) of Section 2.06 hereof,
but subject to the

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requirements of this Section. Prepayments under this subparagraph (a) of any Loan
shall be subject to the following additional conditions:

          (1) In giving notice of prepayment as hereinafter provided, Borrower shall specify, for
the purpose of paragraphs (2) and (3) immediately following, the manner of application of
such prepayment as between Alternate Base Rate Borrowings and LIBOR Borrowings.

          (2) Prepayments applied to any LIBOR Rate Borrowing may be made on any Business Day,
provided, that (i) Borrower shall have given Lender at least three (3) Business
Days’ prior irrevocable written or telecopied notice of such prepayment, specifying the
principal amount of the LIBOR Borrowing to be prepaid, the particular LIBOR Borrowing to
which such prepayment is to be applied and the prepayment date; and (ii) if such prepayment
is made on any day other than the last day of the Interest Period corresponding to the LIBOR
Borrowing to be prepaid, Borrower shall pay directly to Lender, on the last day of such
Interest Period, any Consequential Loss as a result of such prepayment.

          (3) Prepayments applied to any Alternate Base Rate Borrowing may be made prior to 1:00
p.m., Austin, Texas time, on any Business Day.

     (b) Borrower shall from time to time on demand by Lender and subject to the
requirements of this Section, prepay the Loans in such amounts as shall be necessary so that
at all times the aggregate outstanding principal amount of the Note shall be less than or
equal to the lesser of (i) the Commitment or (ii) the Borrowing Base.

Section 2.04 Interest Payments.

     (a) Accrued interest on each Loan shall be payable in arrears on each Interest Payment
Date, as well as upon the Maturity Date. After the Maturity Date, accrued and unpaid
interest on the Loans shall be payable on demand.

     (b) All interest hereunder and under the Note shall be computed on the basis of a year
of 360 days, and in each case shall be payable for the actual number of days elapsed
(including the first day but excluding the last day).

Section 2.05 Interest Rates for Loans.

     (a) Subject to Section 8.01 hereof, the outstanding principal balance of the
Loans shall bear interest on and after the date of this Agreement at the Alternate Base
Rate; provided, that (1) all principal outstanding after the occurrence of an Event
of Default which has not been cured or waived in writing by Lender shall bear interest at
the Default Rate, (2) past due principal and interest shall bear interest at the Default
Rate, which shall be payable on demand, and (3) subject to the provisions hereof, Borrower
shall have the option of having all or any portion of the principal balances from time to
time outstanding under the Loans bear interest until their respective maturities at a rate

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per annum equal to the Adjusted LIBOR Rate (together with the Alternate Base Rate,
individually herein called an “Interest Option” and collectively called
“Interest Options”). The records of Lender, with respect to Interest Options,
Interest Periods and the amounts of the Loans to which they are applicable shall be binding
and conclusive, absent manifest error. Interest on the Loans shall be calculated at the
Alternate Base Rate, except where it is expressly provided pursuant to this Agreement that
the Adjusted LIBOR Rate is to apply.

     (b) In accordance with the provisions hereof, and provided no Default or Event of
Default has occurred and is continuing, Borrower may elect to have the Adjusted LIBOR Rate
apply or continue to apply to all or any portion of the principal balances of the Loans.
Each change in Interest Options shall be a conversion of the rate of interest applicable to
the specified portion of the Loans, but such conversion alone shall not change the
outstanding principal balance of the Loans and the Note. The Interest Options shall be
designated or converted in the manner provided below:

     (1) Borrower shall give Lender by telephone, promptly confirmed by written
notice (the “Rate Selection Notice”) substantially in the form of
Exhibit B hereto. Each such telephone and written notice shall specify the
amount and type of borrowings which are the subject of the designation, if any; the
amount and type of borrowings into which such borrowings are to be converted or for
which an Interest Option is designated; the proposed date for the designation or
conversion (which, in the case of conversion of LIBOR Borrowings, shall be the last
day of the Interest Period applicable thereto) and the Interest Period or Periods,
if any, selected by the Borrower. Such notice by telephone shall be irrevocable and
shall be given to Lender no later than the applicable Rate Selection Date. If a new
Loan is to be a LIBOR Borrowing, then the Rate Selection Notice shall be included in
the Request for Loan applicable to the new Loan, which shall be given to Lender no
later than the applicable Rate Selection Date;

     (2) No more than six (6) LIBOR Borrowings and corresponding Interest Periods
shall be outstanding at any one time with respect to the Loans. Each LIBOR
Borrowing shall be in a minimum aggregate principal amount of at least $250,000,
with any increases over such minimum amount being in integral aggregate multiples of
$50,000;

     (3) Principal included in any borrowing shall not be included in any other
borrowing which exists at the same time;

     (4) Each designation or conversion shall occur on a Business Day; and

     (5) Except as provided in Section 2.06 hereof, no LIBOR Borrowing shall
be converted on any day other than the last day of the applicable Interest Period.

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     (c) All interest will be computed on the basis of a year of 360 days and actual days
elapsed (including the first day but excluding the last day) occurring in the period for
which payable, unless the effect of so computing shall be to cause the rate of interest to
exceed the Ceiling Rate.

Section 2.06 Special Provisions Applicable to LIBOR Borrowings.

     (a) If, after the date of this Agreement, the adoption of any applicable Legal
Requirement or any change in any applicable Legal Requirement or in the interpretation or
administration thereof by any Governmental Authority or compliance by Lender with any
request or directive (whether or not having the force of law) of any Governmental Authority
shall at any time make it unlawful or impracticable for Lender to permit the establishment
of or to maintain any LIBOR Borrowing, the commitment of Lender to establish or maintain the
LIBOR Borrowings affected by such adoption or change shall forthwith be canceled and the
Borrower shall forthwith, upon demand by Lender to Borrower, (1) convert such LIBOR
Borrowings to Alternate Base Rate Borrowings; (2) pay all accrued and unpaid interest to
date on the amount so converted; and (3) pay any amounts required under paragraph (d) below.
All present and subsequent requests for LIBOR Borrowings by Borrower shall be deemed to be
requests for Alternate Base Rate Borrowings with respect to Lender for all LIBOR Borrowings
affected by such adoption or change until such adoption or change no longer affects the
LIBOR Borrowings for Lender.

     (b) If the adoption of any applicable Legal Requirement or any change in any applicable
Legal Requirement or in the interpretation or administration thereof by any Governmental
Authority or compliance by Lender with any request or directive (whether or not having the
force of law) from any Governmental Authority shall at any time as a result of any portion
of the principal balance of the Loans being maintained on the basis of the Adjusted LIBOR
Rate impose, modify, increase or deem applicable any reserve requirement, special deposit
requirement or similar requirement (including state law requirements and Regulation D, but
excluding Statutory Reserves) against assets held by Lender, or against deposits or accounts
in or for the account of Lender, or against loans made by Lender, or against any other
funds, obligations or other Property owned or held by Lender and the result of any of the
foregoing is to increase the cost to Lender of agreeing to make or of making, renewing or
maintaining such borrowing on the basis of the Adjusted LIBOR Rate, or reduce the amount of
principal or interest received by Lender, then Borrower shall pay to Lender from time to
time additional amounts sufficient to compensate such Lender for such increased cost or
reduced amount.

     (c) If for any reason with respect to any Interest Period, Lender shall have determined
(which determination shall be conclusive and binding upon Borrower) that: (1) Lender is
unable through its customary general practices to determine a rate at which Lender is
offered deposits in United States dollars by prime banks in the London interbank market, in
the appropriate amount for the appropriate period, or by reason of circumstances affecting
the London interbank market, generally, Lender is not being

24

 

offered deposits for the applicable Interest Period and in an amount equal to the
amount any LIBOR Borrowing requested by Borrower, or (2) the Adjusted LIBOR Rate will not
adequately and fairly reflect the cost to Lender of making and maintaining any LIBOR
Borrowing hereunder for any proposed Interest Period, then Lender shall give Borrower notice
thereof and thereupon, (A) any Rate Selection Notice previously given by Borrower
designating an Adjusted LIBOR Rate which has not commenced as of the date of such notice
from Lender shall be deemed for all purposes hereof to be of no force and effect, as if
never given, and (B) until Lender shall notify Borrower that the circumstances giving rise
to such notice from Lender longer exist, each Rate Selection Notice requesting an Adjusted
LIBOR Rate shall be deemed a request for an Alternate Base Rate Borrowing, and each
outstanding LIBOR Borrowing then in effect shall be converted, without any notice to or from
the Borrower, upon the termination of the Interest Period then in effect to an Alternate
Base Rate Borrowing.

     (d) Borrower hereby agrees to indemnify Lender against and hold Lender harmless from
any actual loss or expense that Lender may sustain or incur as a consequence of (i) failure
by Borrower to timely convert or borrow any LIBOR Borrowing after Borrower has given a
notice requesting the same in accordance with the provisions of this Agreement, (ii) failure
by Borrower to make any prepayment after Borrower has given a notice thereof in accordance
with the provisions of this Agreement or (iii) the making of a payment or prepayment of any
LIBOR Borrowing, or the conversion of any LIBOR Borrowing, on a day that is not the last day
of an Interest Period with respect thereto, including without limitation, in each case, any
such loss or expense arising from the liquidation or reemployment of funds obtained by
Lender or from fees payable to terminate the deposits from which such funds were obtained.

     (e) If Borrower requests quotes of the Adjusted LIBOR Rate for different Interest
Periods being considered for election by Borrower, Lender will use reasonable efforts to
provide such quotes to Borrower promptly. However, all such quotes provided shall be
representative only and shall not be binding on Lender, nor shall they be determinative,
directly or indirectly, of any Adjusted LIBOR Rate or any component of any such rate, nor
will Borrower’s failure to receive or Lender’s failure to provide any requested quote or
quotes either (1) excuse or extend the time for performance of any obligation of Borrower or
for the exercise of any right, option or election of Borrower or (2) impose any duty or
liability on Lender. If Borrower requests a list of the Business Days in any calendar
month, Lender will use reasonable efforts to provide such list promptly. However, any such
list provided shall be understood to identify only those days which Lender believes in good
faith at the time such list is prepared will be the Business Days for such month. Lender
shall not have any liability for any failure to provide, delay in providing, error or
mistake in or omission from, any such quote or list.

     (f) With respect to Lender having a LIBOR Lending Office which differs from its
Domestic Lending Office, all Loans that are part of LIBOR Borrowings advanced by Lender’s
LIBOR Lending Office shall be deemed to have been made by

25

 

Lender and the obligation of Borrower to repay such Loans shall nevertheless be to
Lender and shall be deemed held by Lender for the account of Lender’s LIBOR Lending Office.

Section 2.07 Increased Costs.

     (a) If Lender reasonably determines that any Change in Law regarding capital
requirements has or would have the effect of reducing the rate of return on Lender’s capital
or on the capital of Lender’s holding company, if any, as a consequence of this Agreement or
the Loans to a level below that which Lender or Lender’s holding company could have achieved
but for such Change in Law (taking into consideration Lender’s policies and the policies of
Lender’s holding company with respect to capital adequacy), then from time to time Borrower
will pay to Lender such additional amount or amounts as will compensate Lender or Lender’s
holding company for any such reduction suffered.

     (b) A certificate of Lender setting forth the amount or amounts necessary to compensate
Lender or its holding company, as the case may be, as specified in paragraph (a) of
this Section shall be delivered to Borrower, demonstrating in reasonable detail the
calculation of the amounts, and shall be conclusive absent manifest error. Borrower shall
pay Lender the amount shown as due on any such certificate within ten (10) days after
receipt thereof.

     (c) Failure or delay on the part of Lender to demand compensation pursuant to this
Section shall not constitute a waiver of Lender’s right to demand such compensation;
but Borrower shall not be required to compensate Lender pursuant to this Section for
any increased costs or reductions incurred more than 180 days before the date that Lender
notifies Borrower of the Change in Law giving rise to such increased costs or reductions and
of Lender’s intention to claim compensation therefor; provided further that,
if the Change in Law giving rise to such increased costs or reductions is
retroactive and if Lender notifies Borrower of such Change of Law within 180 days
after the adoption, enactment or similar act with respect to such Change of Law, then the
180-day period referred to above shall be extended to include the period from the effective
date of such Change of Law to the date of such notice.

Section 2.08 Payments Generally.

     (a) All payments of the Obligations hereunder shall be made to Lender at Lender’s
address specified pursuant to Section 8.08, or at any other office of Lender
specified in writing by Lender to Borrower, by noon (local time) on the date when due.
Lender is hereby authorized to charge any account of Borrower maintained with Lender or any
of its Affiliates for each payment of principal, interest and fees as it becomes due
hereunder.

     (b) Borrower shall make each payment required to be made by it hereunder or under any
other Credit Document (whether of principal, interest or fees, or other amounts

26

 

payable under Article II or otherwise) on or before the time expressly required
hereunder or under such other Credit Document for such payment (or, if no such time is
expressly required, before 2:00 p.m., Austin, Texas time), on the date when due, in
immediately available funds, without set-off, deduction or counterclaim. Any amounts
received after such time on any date may, in the discretion of Lender, be deemed to have
been received on the next succeeding Business Day for purposes of calculating interest
thereon. If any payment under any Credit Document shall be due on a day that is not a
Business Day, the date for payment shall be extended to the next succeeding Business Day,
and, in the case of any payment accruing interest, interest thereon shall be payable for the
period of such extension. Unless otherwise specified therein, all payments under each
Credit Document shall be made in Dollars.

     (c) If at any time insufficient funds are received by and available to Lender to pay
fully all amounts of principal, interest and fees then due hereunder, such funds shall be
applied (i) first, towards payment of interest and fees then due hereunder, and (ii) second,
towards payment of principal then due hereunder.

ARTICLE III

Conditions Precedent

     Section 3.01 All Loans. The obligation of Lender to make any Loan is subject to the
accuracy in all material respects of all representations and warranties of Borrower or any other
Obligor in this Agreement or any other Credit Document on the date thereof (except where such
representation or warranty specifically relates to an earlier date or except for any changes in any
such representation or warranty that would not result in or constitute a Default or Event of
Default), and if requested by Lender, receipt by Lender of evidence of such accuracy, to the
performance by Borrower and the other Obligors of their respective obligations under the Credit
Documents (and Lender’s receipt of evidence of such performance) and to the satisfaction of the
following conditions:

     (a) with respect to any Loan, Lender shall have received by no later than 11:00 a.m. on
the date of such requested Loan, telephonic notice from Borrower of the proposed date and
amount of such Loan, and by no later than 1:00 p.m. on such date, a Request for Loan, signed
by an officer of Borrower;

     (b) prior to the date thereof, there shall have occurred, in the reasonable opinion of
Lender, no Material Adverse Effect;

     (c) no Default or Event of Default shall have occurred and be continuing or will occur
as a result of the requested Loan;

     (d) the making of the Loan shall not be prohibited by, or subject Lender to any penalty
or onerous condition under, any applicable Legal Requirement;

27

 

     (e) all of the Credit Documents have been executed and delivered, and shall be valid,
enforceable and in full force and effect;

     (f) all fees and expenses due and payable to Lender under any of the Credit Documents
as of the date thereof shall have been paid in full;

     (g) Lender shall have received evidence reasonably satisfactory to Lender as to the
perfection and priority of the Liens created by the Security Documents; and

     (h) Lender shall have received such other documents as it may reasonably require.

Delivery of any Request for Loan to Lender shall constitute a representation by Borrower that the
representations and warranties made by Borrower under this Agreement and the other Credit Documents
are true and correct in all material respects as of the date of delivery of such Request for Loan
(except where such representation or warranty specifically relates to an earlier date or except for
any changes in any such representation or warranty that would not result in or constitute a Default
or Event of Default).

     Section 3.02 Initial Loans. In addition to the conditions described in Section
3.01 hereof, the obligation of Lender to make the initial Loan hereunder is subject to the
receipt by Lender of each of the following, in Proper Form:

     (a) the Note, all Security Documents and the other Credit Documents;

     (b) the Organizational Documents of Borrower, Luminex International Corporation, and
Luminex Project, Inc., together with (i) a duly executed Borrowing Authorization with
respect to Borrower, Luminex International Corporation, and Luminex Project, Inc. and (ii)
other reasonably satisfactory evidence confirming that the ownership, organizational
structure and capitalization of Borrower is consistent in all material respects to the
written descriptions thereof previously furnished to Lender;

     (c) a current certificate of existence and good standing from the Delaware Secretary of
State as to the continued existence and good standing of Borrower, Luminex International
Corporation, and Luminex Project, Inc. in the State of Delaware;

     (d) a current certificate of existence from the Texas Secretary of State as to the
continued qualification of Borrower to do business in the State of Texas, and a current
certificate of account status from the Texas Secretary as to the continued good standing of
Borrower in the State of Texas;

     (e) certificates of insurance satisfactory to Lender in all respects evidencing the
existence of all insurance required to be maintained by Borrower pursuant to the terms of
this Agreement and the Security Documents;

28

 

     (f) a legal opinion from independent legal counsel for Borrower, Luminex International
Corporation, and Luminex Project, Inc. dated as of the date of this Agreement, addressed to
Lender and reasonably acceptable in all respects to the Lender, covering the existence and
good standing of Borrower, Luminex International Corporation, and Luminex Project, Inc. as
of the date thereof and the due authorization, execution, delivery and enforceability of the
Credit Documents then delivered by Borrower, Luminex International Corporation, and Luminex
Project, Inc. as of the effective date of this Agreement;

     (g) a Borrowing Base Certificate dated as of the date of the initial Loan hereunder,
together with (i) a listing and aging of the Accounts of Borrower and its wholly-owned
Domestic Subsidiaries covering the Accounts of such Persons as of the end of the most recent
calendar month ending prior to the date of the initial Loan hereunder, prepared in
reasonable detail and containing such information as Lender may request, and (ii) an
Inventory summary or listing as of the end of the most recent calendar month ending prior to
the date of the initial Loan hereunder for the Inventory of Borrower and its wholly-owned
Domestic Subsidiaries;

     (h) evidence satisfactory to Lender that the aggregate amount of all cash, Cash
Equivalents and Marketable Securities held by the Borrower as of the date of this Agreement
and that is unencumbered, unrestricted and not subject to any Liens (other than Permitted
Encumbrances) is equal to or greater than the sum of (1) the aggregate amount of Funded
Indebtedness owing as of such date by Borrower and TM Bioscience Corporation, on a pro-forma
consolidated basis as if the TMB Acquisition had been consummated as of the date of this
Agreement (excluding up to $4,000,000 of Indebtedness then owing to any Canadian
Governmental Authority), and (2) $10,000,000;

     (i) a pro-forma consolidated balance sheet, income statement and cash flow statement
for the Borrower and TM Bioscience Corporation, together with a pro-forma funds flow/sources
and uses statement for the TMB Acquisition, acceptable to the Lender in its sole discretion,
assuming the TMB Acquisition had been consummated and the payment of the Indebtedness of TM
Bioscience Corporation that is contemplated to be paid with proceeds of the Loans; and

     (k) projections for the Borrower’s consolidated operations after the TMB Acquisition
has been consummated sufficiently detailing contemplated revenue growth and expense
reductions resulting from the TMB Acquisition that are acceptable in the Lender’s sole
discretion.

29

 

ARTICLE IV

Representations and Warranties

     Borrower represents and warrants to Lender that:

     Section 4.01 Organization; Authorization. Borrower is duly organized, validly
existing and in good standing under the laws of the state of Delaware and has full legal right,
power and authority to carry on its business as presently conducted and to execute, deliver and
perform its obligations under the Credit Documents, and Borrower is duly qualified to do business
and in good standing in the state of Texas and each other jurisdiction in which the nature of its
business makes such qualification necessary or desirable, except for those jurisdictions in which
the failure to qualify and/or be in good standing would not reasonably be expected to result in a
Material Adverse Effect. Borrower’s and its wholly-owned Subsidiaries’ execution, delivery and
performance of the Credit Documents to which they are a party have been duly authorized by all
necessary action under the Organizational Documents of Borrower and its wholly-owned Subsidiaries
and otherwise.

     Section 4.02 No Consents Necessary. The execution, delivery and performance of the
Credit Documents by Borrower and each of its Subsidiaries do not and will not require (i) any
consent of any other Person or (ii) any consent, license, permit, authorization or other approval
of any court, arbitrator, administrative agency or other Governmental Authority, or any notice to,
exemption by, any registration, declaration or filing with or the taking of any other action in
respect of, any such court, arbitrator, administrative agency or other Governmental Authority,
except where the failure to obtain any of the foregoing would not reasonably be expected to result
in a Material Adverse Effect.

     Section 4.03 No Conflicts. Neither execution or delivery of any Credit Document, nor
the fulfillment of or compliance with its terms and provisions will (i) violate any Legal
Requirement or the Organizational Documents of Borrower or any of its Subsidiaries, other than
those violations, if any, which would not reasonably be expected to result in a Material Adverse
Effect, or (ii) conflict with or result in a breach of the terms, conditions or provisions of, or
cause a default under, any material agreement, instrument, franchise, license or concession to
which Borrower (or any of its Subsidiaries) is a party or bound, other than those conflicts,
breaches or defaults, if any, which would not reasonably be expected to result in a Material
Adverse Effect.

     Section 4.04 Enforceability. Each Credit Document has been duly and validly executed,
issued and delivered by Borrower (or its applicable Domestic Subsidiaries, when and if applicable).
They are in proper legal form for prompt enforcement and they are the respective valid and legally
binding obligations of Borrower (or its applicable Domestic Subsidiaries, when and if applicable),
enforceable in accordance with their terms, except to the extent limited by (a) applicable
bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, and other laws relating
to or affecting the rights of creditors generally, and (b) the exercise of judicial discretion in
accordance with general principles of equity, regardless of whether such enforceability is
considered in a proceeding at law or in equity. The obligations of Borrower (or its applicable
Subsidiaries, when and if applicable) under them rank and will rank at least equal in priority of
payment with all of Borrower’s and/or its Subsidiaries’ other Indebtedness (except only for
Indebtedness preferred by operation of law or Indebtedness disclosed in writing to Lender before
execution and delivery of this Agreement).

30

 

     Section 4.05 Financial Condition; Title to Property. All material written information
supplied to Lender by or on behalf of Borrower before, concurrently with or after execution of this
Agreement are and will be true, correct, complete in all material respects when made. Borrower’s
financial statements furnished to Lender fairly present in all material respects the consolidated
financial condition of Borrower and its Subsidiaries, if any, as of its date and for the period
then ended. No material adverse change has occurred in the financial conditions reflected in the
most recent of such financial statements furnished to Lender since the date thereof which could
reasonably be expected to result in a Material Adverse Effect. Borrower and its Subsidiaries have
good and marketable title to, or a valid leasehold interest in, all of the Property and assets
shown on the most recent consolidated balance sheet for Borrower provided under the terms of
Section 5.2, and all assets and Property acquired since the date of such respective balance
sheets, except for such Property as is no longer used or useful in the conduct of Borrower’s or its
applicable Subsidiary’s business or as have been disposed of in the ordinary course of business,
and except for minor defects in title that do not interfere with the ability of Borrower and its
Subsidiaries to conduct their respective businesses.

     Section 4.06 Taxes. Borrower has filed all tax returns required to be filed and paid
all taxes shown thereon to be due, including interest and penalties, except for taxes which are
being diligently contested in good faith and for payment of which adequate reserves have been set
aside.

     Section 4.07 Litigation. As of the date hereof, there is no condemnation or other
action, suit or proceeding pending—or, to the best of Borrower’s knowledge, threatened—against or
affecting Borrower, any of its Subsidiaries or the Collateral, at law or in equity, or before or by
any Governmental Authority, which could reasonably be expected to result in any Material Adverse
Effect.

     Section 4.08 No Defaults. Neither Borrower nor any of its Subsidiaries is in default
with respect to any order, writ, injunction, decree or demand of any court or other Governmental
Authority, or in the payment of any Indebtedness for borrowed money in an aggregate amount
exceeding $250,000.00.

     Section 4.09 Intentionally Deleted.

     Section 4.10 Solvency. Borrower is now solvent, and no bankruptcy or insolvency
proceedings are pending or contemplated by or—to Borrower’s knowledge threatened—against
Borrower. Borrower’s liabilities and obligations under the Credit Documents do not and will not
render Borrower insolvent, cause Borrower’s liabilities to exceed Borrower’s assets or leave
Borrower with too little capital to properly conduct all of its business as now conducted or
contemplated to be conducted.

     Section 4.11 Prior Representations. No representation or warranty contained in any
Credit Document and no statement contained in any material report, financial statement or other
papers furnished to Lender by or on behalf of Borrower or any of its Subsidiaries contains any
untrue statement of material fact, or omits to state a material fact necessary to make the

31

 

statements contained therein, taken as a whole, not misleading in light of the circumstances
under which such statements were provided.

     Section 4.12 Margin Stock. None of the proceeds of the Note will be used for the
purpose of purchasing or carrying, directly or indirectly, any margin stock or for any other
purpose which would make such credit a “purpose credit” within the meaning of Regulation U of the
Board of Governors of the Federal Reserve System.

     Section 4.13 Permits. Borrower and its Subsidiaries possess all permits, licenses,
patents, trademarks, tradenames and copyrights required to conduct its business, except where the
failure to obtain any of the foregoing would not reasonably be expected to result in a Material
Adverse Effect.

     Section 4.14 Legal Requirements. Borrower, its Subsidiaries and the Collateral are in
compliance in all material respects with all applicable Legal Requirements and Borrower and each of
its Subsidiaries manages and operates (and will continue to manage and operate) its business in
accordance with good industry practices, except where the failure to comply with applicable Legal
Requirements or to otherwise manage and operate in accordance with good industry practices would
not reasonably be expected to result in a Material Adverse Effect.

     Section 4.15 ERISA. With respect to each Plan, Borrower, each of its Subsidiaries and
each member of a Controlled Group for the employees of Borrower or any of its Subsidiaries have
fulfilled their obligations, including obligations under the minimum funding standards of ERISA and
the Code and are in compliance in all material respects with the provisions of ERISA and the Code.
No event has occurred which could result in a material liability of Borrower, any of its
Subsidiaries or any member of a Controlled Group for the employees of Borrower or any of its
Subsidiaries to the PBGC regarding a Plan or a Plan (other than to make contributions in the
ordinary course). Since the effective date of Title IV of ERISA, there have not been any nor are
there now existing any events or conditions regarding a Plan that would cause the Lien provided
under Section 4068 of ERISA to attach to any Property of Borrower, any of its Subsidiaries or any
member of a Controlled Group for the employees of Borrower or any of its Subsidiaries. There are
no Unfunded Liabilities with respect to any Plan. No “prohibited transaction” has occurred with
respect to any Plan.

     Section 4.16 Investment and Holding Company Status.

     (a) Neither Borrower nor any of its Subsidiaries is an investment company within the
meaning of the Investment Company Act of 1940, as amended, or, directly or indirectly,
controlled by or acting on behalf of any Person which is an investment company, within the
meaning of said Act.

     (b) Neither Borrower nor any of its Subsidiaries is an “affiliate” or a “subsidiary
company” of a “public utility company,” or a “holding company,” or an “affiliate” or a
“subsidiary company” of a “holding company,” as such terms are defined in the Public Utility
Holding Company Act of 1935, as amended (“PUHC Act”). Further, none of the
transactions contemplated under this Agreement shall cause or constitute a

32

 

violation of any of the provisions, rules, regulations or orders of or under the PUHC
Act and the PUHC Act does not in any manner impair the legality, validity or enforceability
of the Note, the liabilities of Borrower or any of its Subsidiaries under any of the Credit
Documents or any Liens created under the Security Documents.

     Section 4.17 Environmental Matters. Except as disclosed in writing to Lender before
execution and delivery of this Agreement, (a) Borrower and each of its Subsidiaries has obtained
and maintained in effect all Environmental Permits, the failure to obtain which could reasonably be
expected to have a Material Adverse Effect, (b) Borrower and each of its Subsidiaries (and, to
their knowledge, their Properties, business and operations) has been and is in compliance with all
applicable Requirements of Environmental Law and Environmental Permits, the failure to obtain which
could reasonably be expected to have a Material Adverse Effect, (c) as of the date hereof, neither
Borrower nor any of its Subsidiaries (or any of their Properties, business and operations) is
subject to any (i) Environmental Claims or (ii) Environmental Liabilities, in either case direct or
contingent, and whether known or unknown, arising from or based upon any act, omission, event,
condition or circumstance occurring or existing on or prior to the date hereof which could
reasonably be expected to have a Material Adverse Effect, and (d) neither Borrower nor any of its
Subsidiaries has received any notice of any violation or alleged violation of any Requirements of
Environmental Law or Environmental Permit or any Environmental Claim in connection with its
Properties, business or operations which could reasonably be expected to have a Material Adverse
Effect. The liability (including any Environmental Liability and any other damage to persons or
Property), if any, of Borrower and each of its Subsidiaries with respect to their Properties,
business and operations which is reasonably expected to arise in connection with Requirements of
Environmental Laws currently in effect and other environmental matters presently known by Borrower
is not reasonably expected to have a Material Adverse Effect. Neither Borrower nor any of its
Subsidiaries knows of any event or condition with respect to Environmental Matters with respect to
any of its Properties which could reasonably be expected to have a Material Adverse Effect. The
provisions of this Section are cumulative of the provisions relating to this subject matter in the
other Credit Documents.

     Section 4.18 Executive Offices; Fiscal Year. As of the date hereof, (a) Borrower’s
principal place of business and chief executive office is 12212 Technology Boulevard, Austin, Texas
78727, and (b) Borrower’s fiscal year is January 1st to December 31st of each calendar
year.

     Section 4.19 Subsidiaries. As of the date hereof, Borrower has no Subsidiaries,
other than (a) Luminex International Corporation, a Delaware corporation, (b) Luminex Project,
Inc., a Delaware corporation, and (c) Luminex B.V., a Dutch private limited liability company. TM
Bioscience Corporation will become a wholly-owned non-Domestic Subsidiary of Borrower upon
consummation of the TMB Acquisition.

     Section 4.20 Subordinated Indebtedness. As of the date hereof, Borrower has no
Subordinated Indebtedness.

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ARTICLE V

Affirmative Covenants

     Borrower covenants and agrees with Lender that prior to termination of this Agreement:

     Section 5.01 Existence; Conduct of Business. Borrower shall (and shall cause each of
its Subsidiaries to) at all times (a) pay when due all material taxes and governmental charges of
every kind upon it or against its income, profits or Property, unless and only to the extent that
the same shall be contested diligently in good faith and reserves reasonably deemed adequate by
Lender have been established therefor; (b) to the extent applicable, do all things reasonably
necessary to preserve its existence, qualifications, rights and franchises in all states where such
qualification is necessary or desirable, except to the extent that the failure to comply with the
foregoing requirements would not reasonably be expected to result in a Material Adverse Effect; (c)
comply with all applicable Legal Requirements (including Requirements of Environmental Law) in
respect of the conduct of its business and the ownership of its Property, except to the extent that
the failure to comply with the foregoing requirements would not reasonably be expected to result in
a Material Adverse Effect; (d) cause its Property to be protected, maintained and kept in good
repair (ordinary wear and tear and casualty expected) and make all replacements and additions to
its Property as may be reasonably necessary to conduct its business properly and efficiently,
except to the extent that the failure to comply with the foregoing requirements would not
reasonably be expected to result in a Material Adverse Effect, and (e) pay punctually and discharge
when due, or renew or extend, any Indebtedness incurred by it and discharge, perform and observe
the covenants, provisions and conditions to be performed, discharged and observed on its part in
connection therewith, or in connection with any agreement or other instrument relating thereto or
in connection with any mortgage, pledge or lien existing at any time upon any of its Property,
except to the extent that the failure to comply with the foregoing requirements would not
reasonably be expected to result in a Material Adverse Effect; provided, however,
that nothing contained in this subparagraph (e) shall require payment, discharge, renewal
or extension of any such Indebtedness or discharge, performance or observance of any such
covenants, provisions and conditions so long as any claims which may be asserted against with
respect to any such Indebtedness or any such covenants, provisions and conditions shall be
contested diligently and in good faith and reserves with respect thereto deemed adequate by Lender
shall be established.

     Section 5.02 Financial Statements and Other Information. Borrower shall furnish or
cause to be furnished to Lender a copy of each of the following:

     (a) as soon as available and in any event within 125 days after the end of each fiscal
year of Borrower, Annual Audited Financial Statements of Borrower and its Subsidiaries;

     (b) as soon as available and in any event within 45 days after the end of each fiscal
quarter, Quarterly Financial Statements of Borrower and its Subsidiaries;

     (c) within thirty-five (35) days after the end of each calendar month, (i) a Borrowing
Base Certificate as of the last day of such calendar month, together with such

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supporting information as Lender may reasonably request, certified and signed by an
appropriate officer or other responsible party acceptable to Lender on behalf of Borrower,
(ii) a listing and aging of the Accounts of Borrower and each of its wholly-owned Domestic
Subsidiaries as of the end of such calendar month, prepared in reasonable detail and
containing such information as Lender may request, and (iii) a summary of the Inventory of
Borrower and each of its wholly-owned Domestic Subsidiaries as of the end of such calendar
month, prepared in reasonable detail and containing such information as Lender may request;

     (d) concurrently with the financial statements provided for in subsections (a)
and (b) of this Section 5.02 (including the Quarterly Financial Statements
of Borrower to be delivered as of the last fiscal quarter of any fiscal year), a compliance
certificate (“Compliance Certificate”) in the form of Exhibit D hereto
accompanied by such schedules, computations and other information, in reasonable detail, as
may be required by Lender to demonstrate compliance with the covenants set forth herein or
reflecting any non-compliance therewith as of the applicable date, all certified and signed
by an appropriate officer or other responsible party acceptable to Lender on behalf of
Borrower;

     (e) from time to time, at any time upon the request of Lender, but at the cost of
Borrower (subject to the limitation set forth below), a report of a collateral field
examiner or auditor (which may or may not be affiliated with Lender) with respect to the
Accounts and Inventory included in the Borrowing Base (provided, however,
that so long as no Event of Default has occurred and is continuing, Borrower shall not be
required to pay or reimburse to Lender the cost and expense of such a report more than once
per calendar year when no Event of Default exists); and

     (f) such other information relating to the financial condition, operations, prospects
or business of any Obligor as from time to time may be reasonably requested by Lender. Each
delivery of a financial statement pursuant to this Section 5.02 shall constitute a
republication of the representations and warranties contained in Article IV (except
where such representation or warranty specifically relates to an earlier date or except for
any changes in any such representation or warranty that would not result in or constitute a
Default or Event of Default).

     Section 5.03 Financial Covenants. Borrower shall have and maintain on a consolidated
basis:

     (a) Tangible Net Worth. Borrower and its Subsidiaries shall maintain a
consolidated Tangible Net Worth in an amount greater than or equal to (i) $45,000,000 at all
times prior to the consummation of the TMB Acquisition and (ii) $25,000,000 at all times on
and after the consummation of the TMB Acquisition.

     (b) Cash, Cash Equivalents and Marketable Securities. Borrower and its
wholly-owned Domestic Subsidiaries shall at all times hold and own unencumbered and
unrestricted cash, Cash Equivalents and Marketable Securities not subject to any Liens
(other than Permitted Encumbrances) in an aggregate amount of not less than Funded

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Indebtedness owing as of such calculation date by Borrower and its Subsidiaries
(including TM Bioscience Corporation, on a pro-forma consolidated basis if the TMB
Acquisition has not yet been consummated as of the date of such calculation), but excluding
up to $4,000,000 of Indebtedness then owing to any Canadian Governmental Authority.

     Section 5.04 Books and Records; Inspection Rights. Borrower shall (and shall cause
each of its Subsidiaries to) maintain books and records in accordance with GAAP. Borrower shall
permit Lender and any consultant of Lender to inspect its Property, to examine its files, books and
records and make and take away copies thereof, and to discuss its affairs with its officers and
accountants, upon reasonable notice to Borrower and during normal business hours so long as no
Event of Default exists; otherwise, all at such times and intervals and to such extent as Lender
may reasonably desire. In connection therewith, Lender and any consultant of Lender shall each
have the right to examine, upon reasonable notice to Borrower and during normal business hours so
long as no Event of Default exists; otherwise, as often as Lender may request, the existence and
condition of any of the Collateral and to review Borrower’s and its Subsidiaries’ compliance with
the terms and conditions of this Agreement and the other Credit Documents, subject to governmental
confidentiality requirements.

     Section 5.05 Further Assurances. Borrower shall promptly execute and deliver (or
cause to be executed and delivered), at Borrower’s expense, any and all other and further
instruments which may be reasonably requested by Lender to cure any defect in the execution and
delivery of any Credit Document or more fully to describe particular aspects of the agreements and
undertakings set forth in the Credit Documents.

     Section 5.06 Insurance. Borrower shall maintain insurance with such insurers, on such
of its and its Subsidiaries’ Property, in such amounts and against such risks as is reasonably
satisfactory to Lender, including without limitation, fire and extended coverage, general liability
insurance and worker’s compensation coverage, and furnish Lender satisfactory evidence thereof
promptly upon request. These insurance provisions are cumulative of the insurance provisions of the
Security Documents. With respect to all such insurance, (a) Lender shall be named as an
“additional loss payee” or “additional insured,” as applicable, in its capacity as a lender and
mortgagee, and shall be provided with one or more certificates of the insurer that the insurance
required by this paragraph may not be canceled, reduced or affected in any manner without thirty
(30) days’ prior written notice to Lender, and (b) Borrower shall promptly furnish copies of such
policies of insurance upon written request therefor by Lender. Wherever permitted and available
under applicable law, such insurance shall name Lender as loss payee and/or mortgagee insured.

     Section 5.07 Notice of Material Events. Borrower shall notify Lender promptly after
acquiring knowledge of the occurrence of, or if Borrower or any of its Subsidiaries causes or
intends to cause, as the case may be: (a) the institution of any lawsuit or administrative
proceeding affecting Borrower or any of its Subsidiaries, the adverse determination under which
could reasonably be expected to have a Material Adverse Effect; (b) any material adverse change,
either in any case or in the aggregate, in the assets, liabilities, business, condition (financial
or otherwise), operations, Property or prospects of Borrower or any of its Subsidiaries

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which could reasonably be expected to have a Material Adverse Effect; (c) any Event of Default
or any Default, together with a detailed statement by an appropriate officer or other responsible
party acceptable to Lender on behalf of Borrower of the steps being taken to cure the effect of
such Event of Default or Default; (d) the receipt of any notice from, or the taking of any other
action by, the holder(s) of any Indebtedness of Borrower or any of its Subsidiaries in an aggregate
principal amount of $250,000.00 or greater with respect to a claimed default, together with a
detailed statement by an appropriate officer or other responsible party acceptable to Lender on
behalf of Borrower specifying the notice given or other action taken by such holder and the nature
of the claimed default and what action Borrower or its applicable Subsidiaries, as the case may be,
is taking or proposed to take with respect thereto; and (e) any adverse change in any material
respect in the accuracy of the representations and warranties of Borrower or any of its
Subsidiaries in this Agreement or any other Credit Document (except for any representation or
warranty that specifically relates to an earlier date or except for any changes in any such
representation or warranty that would not result in or constitute a Default or Event of Default).
Borrower will notify Lender in writing at least 30 days prior to the date that any Obligor changes
its name or the location of its chief executive office or principal place of business or the place
where it keeps its books and records.

     Section 5.08 ERISA Matters. Borrower shall promptly furnish to Lender (1) promptly
after receipt, a copy of any notice of complete or partial withdrawal liability regarding a Plan
under Title IV of ERISA and any notice from the PBGC under Title IV of ERISA of an intent to
terminate or appoint a trustee to administer any Plan, (2) if requested by Lender, promptly after
the filing thereof with the United States Secretary of Labor or the PBGC or the Internal Revenue
Service, copies of each annual and other report with respect to each Plan or any trust created
thereunder, (3) immediately upon becoming aware of the occurrence of any “reportable event,” as
such term is defined in Section 4043 of ERISA, for which the disclosure requirements of Regulation
Section 2615.3 promulgated by the PBGC have not been waived, or of any “prohibited transaction,” as
such term is defined in Section 4975 of the Code, in connection with any Plan or any trust created
thereunder, a written notice signed by an appropriate officer or other responsible party acceptable
to Lender on behalf of Borrower or its applicable Subsidiaries or the applicable member of a
Controlled Group for the employees of Borrower or its applicable Subsidiaries specifying the nature
thereof, what action Borrower or its applicable Subsidiaries or the applicable member of such
Controlled Group is taking or proposes to take with respect thereto, and, when known, any action
taken by the PBGC, the Internal Revenue Service or the Department of Labor with respect thereto,
(4) promptly after the filing or receiving thereof by Borrower or any of its Subsidiaries or any
member of a Controlled Group for the employees of any such Person of any notice of the institution
of any proceedings or other actions which may result in the termination of any Plan, and (5) each
request for waiver of the funding standards or extension of the amortization periods required by
Sections 303 and 304 of ERISA or Section 412 of the Code regarding a Plan promptly after the
request is submitted by Borrower or any of its Subsidiaries or any member of a Controlled Group for
the employees of any such Person to the Secretary of the Treasury, the Department of Labor or the
Internal Revenue Service, as the case may be. To the extent required under applicable statutory
funding requirements, Borrower will fund, and will cause each of its Subsidiaries to fund, all
current service pension liabilities as they are incurred under the provisions of all Plans from
time to time in effect, and comply with all

37

 

applicable provisions of ERISA. Borrower covenants that it shall and shall cause each other
Obligor and each other member of a Controlled Group for the employees of Borrower and each of its
Subsidiaries to (a) make contributions to each Plan in a timely manner and in an amount sufficient
to comply with the contribution obligations under such Plan and the minimum funding standards
requirements of ERISA; (b) prepare and file in a timely manner all notices and reports required
under the terms of ERISA including annual reports regarding such Plans; and (c) pay in a timely
manner all required PBGC premiums regarding such Plans.

     Section 5.09 Loan Proceeds. The proceeds of the Loans will be used for (a) working
capital purposes for Borrower and, to the extent permitted herein, its Subsidiaries, and (b)
repayment of certain Indebtedness of TM Bioscience Corporation upon consummation of the TMB
Acquisition.

     Section 5.10 Deposits, Treasury Management and Traditional Banking Services. Borrower
shall maintain with Lender substantially all of Borrower’s and its Domestic Subsidiaries’
traditional depository and disbursement accounts, related treasury management services and other
traditional banking services (other than securities account investments held by securities
intermediaries).

     Section 5.11 Operation of TM Bioscience Corporation as a Separate Legal Entity.
Borrower shall cause TM Bioscience Corporation (“TMB”) to fully comply with the following
requirements at all times: (a) TMB shall hold itself out to the public as a legal entity separate
and distinct from Borrower and any other Person and conduct its business solely in its own name and
shall correct any known misunderstanding regarding its separate identity; (b) TMB shall maintain
adequate capital for its normal obligations reasonably foreseeable in a business of its size and
character and in light of its contemplated business operations; (c) TMB shall pay its own
liabilities (including, without limitation, salaries of its own employees) from either its own
funds or funds advanced to TMB by Borrower in compliance with the terms of Sections 6.01(g)
and 6.07(j); (d) TMB shall not assume or guaranty the debts of Borrower or any other
Subsidiary of Borrower, hold itself out to be responsible for the debts of Borrower or any other
Subsidiary of Borrower, or otherwise pledge its assets for the benefit of Borrower or any other
Subsidiary of Borrower or hold out its credit as being available to satisfy the obligations of
Borrower or any other Subsidiary of Borrower; (e) TMB shall file its own tax returns as required
under laws applicable to TMB; (f) TMB shall not commingle its assets with the assets of Borrower,
any other Subsidiary of Borrower or any other Person; (g) TMB shall use separate stationery,
invoices and checks and shall properly and validly allocate shared expenses with Borrower and any
other Subsidiaries of Borrower, to the extent applicable; and (h) TMB shall not maintain its assets
in such a manner that it will be costly or difficult to segregate, ascertain or identify its
individual assets from those of Borrower or any other Person.

ARTICLE VI

Negative Covenants 

     Borrower covenants and agrees with Lender that prior to termination of this Agreement:

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     Section 6.01 Indebtedness. Neither Borrower nor any of its Subsidiaries will create,
incur, suffer or permit to exist, or assume or guarantee, directly or indirectly, or become or
remain liable with respect to any Indebtedness, whether direct, indirect, absolute, contingent or
otherwise, except the following:

     (a) Indebtedness to Lender or any Affiliate of Lender;

     (b) Indebtedness secured by Liens permitted by Section 6.02 hereof;

     (c) other liabilities existing on the date of this Agreement and disclosed in the
financial statements delivered on or prior to the date hereof, and all renewals and
extensions (but not increases) thereof;

     (d) current accounts payable and unsecured current liabilities, not the result of
borrowing, to vendors, suppliers and persons providing services, for expenditures for goods
and services normally required by it in the ordinary course of business and on ordinary
trade terms;

     (e) any Subordinated Indebtedness;

     (f) intercompany Indebtedness among Obligors, so long as any such Obligor other than
Borrower is a wholly-owned Subsidiary of Borrower;

     (g) intercompany Indebtedness owing by a non-Domestic Subsidiary to any Obligor, so
long as (1) Borrower is in compliance with the financial covenants in Section 5.3
hereof after giving effect to all such intercompany Indebtedness extended to non-Domestic
Subsidiaries and all Investments permitted by Section 6.07(j), and (2) all such
intercompany Indebtedness extended to any non-Domestic Subsidiary is evidenced by a valid
and enforceable promissory note executed and payable by the applicable non-Domestic
Subsidiary to the order of the applicable Obligor and the Lender has received a perfected
first priority Lien (subject only to Permitted Encumbrances) against such promissory note;
and

     (h) any other Indebtedness incurred after the date of this Agreement, so long as the
aggregate outstanding principal amount of such other Indebtedness does not exceed
$500,000.00 at any time.

     Section 6.02 Liens. Neither Borrower nor any of its Subsidiaries will create or
suffer to exist any Lien upon any of its Property now owned or hereafter acquired, or acquire any
Property upon any conditional sale or other title retention device or arrangement or any purchase
money security agreement; provided, however, that Borrower or any of its
Subsidiaries may create or suffer to exist:

     (a) Liens in effect on the date hereof and disclosed to Lender in the financial
statements delivered on or prior to the date hereof, provided that neither the Indebtedness
secured thereby nor the Property covered thereby shall increase;

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     (b) Liens in favor of Lender;

     (c) Liens created pursuant to Capital Lease Obligations or purchase money Indebtedness
for fixed assets permitted pursuant to this Agreement, if (1) such Liens are only in
respect of the fixed assets subject to, and secure only, the respective Capital Lease
Obligations or purchase money Indebtedness, and (2) the aggregate outstanding principal
amount of all such Indebtedness does not exceed $500,000.00 at any time; and

     (d) Permitted Encumbrances.

     Section 6.03 Fundamental Changes. Neither Borrower nor any of its Subsidiaries
will, in any single transaction or series of transactions, directly or indirectly, (a) consolidate,
terminate, liquidate or dissolve, (b) be a party to any consolidation, termination, merger or
consolidation, (c) sell, convey or lease all or substantially all of its assets (other than to
Borrower or another Obligor that is a wholly-owned Subsidiary of Borrower), or (d) except for
Permitted Acquisitions, acquire all or substantially all of the assets of any Person, or acquire
any Equity Interests of any other Person, without the prior consent of Lender; provided,
however, that any wholly-owned Subsidiary of an Obligor may (i) consolidate or merge with
Borrower or another Obligor that is a wholly-owned Subsidiary of Borrower or (ii) otherwise
terminate, liquidate or dissolve, so long as all of the assets of such Obligor that is terminating,
liquidating or dissolving are conveyed to Borrower or another Obligor that is a wholly-owned
Subsidiary of Borrower.

     Section 6.04 Asset Sales. Neither Borrower nor any of its Subsidiaries will, in any
single transaction or series of transactions, directly or indirectly, sell, transfer, lease or
otherwise dispose of any of its assets, except for (a) sales or other dispositions in the ordinary
course of business and for fair value and (b) sales or other dispositions to an Obligor.

     Section 6.05 Nature of Business. Borrower and its Subsidiaries, taken as a whole,
will not materially change the nature of their business or enter into any business which is
substantially different from the business in which they are presently engaged.

     Section 6.06 Affiliate Transactions. Neither Borrower nor any of its Subsidiaries
will enter into any material transaction or agreement with any Affiliate or any officer, director,
partner, trustee or owner or holder of any Equity Interests of Borrower or any of its Subsidiaries,
except (a) transactions in the ordinary course of business that are at prices and on terms and
conditions not less favorable to it than could be obtained on an arm’s-length basis from unrelated
third parties, (b) any dividend or other distribution with respect to any Equity Interests in
Borrower or other transaction or agreement otherwise permitted hereunder, and (c) compensation,
employment, severance and benefit arrangements in the ordinary course of business, including
payment of directors’ fees.

     Section 6.07 Investments; Loans; Advances. Neither Borrower nor any of its
Subsidiaries will make any Investment in, any Person, or make any commitment to make any
Investment, except the following:

     (a) Cash Equivalents and Marketable Securities;

40

 

     (b) Permitted Acquisitions;

     (c) accounts receivable, inventory and other working capital accounts, if created in
the ordinary course of business and payable or dischargeable in accordance with customary
trade terms;

     (d) loans or advances to employees, officers or directors in the ordinary course of
business of Borrower or any of its Subsidiaries, in each case only as permitted by
applicable law, including Section 402 of the Sarbanes Oxley Act of 2002, but in any event
not to exceed $50,000.00 in the aggregate at any time outstanding;

     (e) loans or advances to employees, officers or directors of Borrower or any of its
Subsidiaries to purchase Equity Interests in Borrower, in each case only as permitted by
applicable law, including Section 402 of the Sarbanes Oxley Act of 2002, but in any event
not to exceed $100,000.00 in the aggregate at any time outstanding;

     (f) Investments received in satisfaction or partial satisfaction from financially
troubled account debtors as a result of the applicable Obligor’s exercise of its reasonable
business judgment;

     (g) Equity Interests issued by Subsidiaries permitted hereunder;

     (h) Investments in another Obligor;

     (i) Investments existing on the date hereof to the extent the same are reflected in the
most recent financial statements of Borrower furnished to Lender prior to the date of this
Agreement;

     (j) Investments in non-Domestic Subsidiaries of the Borrower, so long as (1) Borrower
is in compliance with the financial covenants in Section 5.3 hereof after giving
effect to all such Investments and all intercompany Indebtedness extended to non-Domestic
Subsidiaries as permitted by Section 6.01(g), and (2) all such Investments extended
to any non-Domestic Subsidiary are evidenced by a valid and enforceable promissory note
executed and payable by the applicable non-Domestic Subsidiary to the order of the
applicable Obligor and the Lender has received a perfected first priority Lien (subject only
to Permitted Encumbrances) against such promissory note; and

     (k) additional Investments not to exceed $100,000 in the aggregate at any time
outstanding.

     Section 6.08 New Subsidiaries. Neither Borrower nor any of its Subsidiaries will form,
create or acquire any Subsidiary, other than TM Bioscience Corporation, without the prior written
consent of Lender, unless (a) Lender is provided not less than fifteen (15) days prior written
notice by Borrower of the intention to create or acquire such new Subsidiary and (b)
contemporaneously with the actual creation or acquisition of such new Subsidiary, as applicable,
Borrower causes (i) each such Subsidiary that is a Domestic Subsidiary to become an Obligor, by

41

 

execution and delivery to Lender, of a Guaranty or a Joinder Agreement (if a Joinder Agreement
is requested by Lender in lieu of a Guaranty), (ii) each such Subsidiary that is a Domestic
Subsidiary to grant to Lender a first priority perfected Lien (subject only to Liens permitted
under Section 6.02) against all Accounts, Equipment, Inventory and General Intangibles and
other related property and proceeds thereof (excluding all copyrights, trademarks, tradenames,
patents and other similar intellectual property), now or hereafter owned by such Domestic
Subsidiary, (iii) each such Subsidiary that is a non-Domestic Subsidiary to execute and deliver a
valid and enforceable promissory note payable by such non-Domestic Subsidiary to the order of
Borrower (or a wholly-owned Domestic Subsidiary of Borrower) for purposes of evidencing all
Investments in, and intercompany Indebtedness at any time extended by Borrower and any other
Obligors to, such non-Domestic Subsidiary, so long as the Lender has received a perfected first
priority Lien (subject only to Permitted Encumbrances) against such promissory note, and (iv) each
such Subsidiary to deliver to Lender such related certificates, legal opinions and documents
(including Organizational Documents) as Lender may reasonably require.

     Section 6.09 ERISA; Unfunded Liabilities. Neither Borrower nor any of its
Subsidiaries will incur any Unfunded Liabilities or allow any Unfunded Liabilities to arise or
exist under any Plan.

     Section 6.10 Sale and Leaseback Transactions. Neither Borrower nor any of its
Subsidiaries will enter into any arrangement, directly or indirectly, whereby it shall sell or
transfer any Property, real or personal, used or useful in its business, whether now owned or
hereinafter acquired, and thereafter rent or lease such Property or other Property that it intends
to use for substantially the same purpose or purposes as the Property sold or transferred.

     Section 6.11 Dividends and Other Distributions. Borrower will not: (a) redeem,
retire or otherwise acquire, directly or indirectly, any of its Equity Interests; or (b) pay any
dividend or make any other distribution of any Property or cash to holders of Equity Interests in
Borrower as such, except (i) non-cash dividends of additional Equity Interests, or (ii) cash
redemptions of any Equity Interests and/or cash dividends to holders of Equity Interests, so long
as no Event of Default then exists (including without limitation, that Borrower is in compliance
with each of the financial covenants in Section 5.03), both immediately prior to and
immediately after giving effect to such cash redemptions or dividends, as applicable.

     Section 6.12 Other Negative Pledge Agreements. Neither Borrower nor any of its
Subsidiaries will enter into any contract or other agreement for any purpose with any Person (other
than (i) the applicable negative covenants of this Agreement and the other Credit Documents and
(ii) the applicable negative covenants of any documentation evidencing Indebtedness secured by
Liens permitted under Section 6.02(c), but only to the extent that such negative covenants
preclude the granting of additional Liens against only those specific fixed assets securing such
permitted Indebtedness) that directly or indirectly prohibits the Borrower or any of its
Subsidiaries from granting any Lien against any Property now or hereafter owned by Borrower or any
of its Subsidiaries.

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ARTICLE VII

Defaults

     Section 7.01 Default. The occurrence of any of the following events shall constitute
an Event of Default (herein so called) under this Agreement:

     (a) any part of the Obligations is not paid within five (5) calendar days after the due
date thereof, whether by lapse of time or acceleration or otherwise;

     (b) Borrower or any of its Subsidiaries fails to perform, observe or comply with—or
defaults under—any of the terms, covenants, conditions or provisions of any Credit Document
(other than any such failure or default described in one of the other subparagraphs of this
Section), and Borrower fails to cure such default within fifteen (15) calendar days after
Lender has given Borrower written notice thereof (such curative period to run concurrently
with, and not in addition to, any other curative periods, if any, provided for in any of the
other Credit Documents with respect to the same default), provided that Lender shall not be
required to provide such notice with respect to any such failure or default which by its
nature is incurable;

     (c) Borrower or any of its Subsidiaries fails to perform, observe or comply with—or
defaults under—Sections 5.02, 5.03 or 5.07 hereof or any negative
covenant under Article VI of this Agreement;

     (d) any representation or warranty made in any Credit Document or in any other material
report or other paper now or hereafter provided to Lender by or on behalf of Borrower or any
other Obligor pursuant or incident to any Credit Document or the Obligations proves to have
been untrue or misleading in any material respect as of the date made or deemed made;

     (e) Borrower or any of its Subsidiaries: (i) voluntarily suspends transaction of
business (except as expressly permitted hereunder); (ii) becomes insolvent or unable to pay
its Indebtedness as it matures; (iii) commences a voluntary case in bankruptcy or a
voluntary petition seeking reorganization or to effect a plan or other arrangement with
creditors; (iv) makes an assignment for the benefit of creditors; (v) applies for or
consents to the appointment of a receiver or trustee for any such person or entity or for
any substantial portion of its Property; or (vi) makes an assignment to an agent authorized
to liquidate any substantial part of its assets;

     (f) in respect of Borrower or any of its Subsidiaries: (i) an involuntary case shall
be commenced with any court or other authority seeking liquidation, reorganization or a
creditor’s arrangement of any such person or entity; (ii) an order of any court or other
authority shall be entered appointing any receiver or trustee for any such person or entity
or for any substantial portion of its Property; or (iii) a writ or warrant of attachment or
any similar process shall be issued by any court or other authority against any substantial
portion of the Property of any such person or entity, and in each case, such petition
seeking liquidation, reorganization or a creditor’s arrangement or such order appointing a

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receiver or trustee is not vacated or stayed, or such writ, warrant of attachment or
similar process is not vacated, released or bonded off within sixty (60) days after its
entry or levy;

     (g) the dissolution, liquidation or termination of the existence of Borrower or any of
its Subsidiaries except as otherwise permitted under this Agreement;

     (h) any action, suit or proceeding shall be commenced against or affecting Borrower or
any of its Subsidiaries or involving the validity or enforceability of any Credit Document,
at law or in equity, or before any Governmental Authority, which in Lender’s reasonable
judgment, impairs or reasonably could impair Lender’s ability in any material respect to
collect the Obligations when due or the enforceability of any Credit Document;

     (i) any one or more final judgments for the payment of money in excess of $100,000.00
in the aggregate shall be rendered against any Obligor and the same shall remain unstayed or
undischarged for a period of 30 days;

     (j) Borrower or any of its Subsidiaries shall be prevented or relieved by any
Governmental Authority from performing or observing any material term, covenant or condition
of any Credit Document;

     (k) Borrower or any of its Subsidiaries shall default in the payment of any amount when
due under any other borrowed money obligation in excess of $250,000.00 in principal amount
or the holder of such other obligation declares—or has the right to declare—such
obligation due before its stated maturity because of default;

     (l) Borrower or any of its Subsidiaries shall be in default under or in violation of
any material Legal Requirement of any Governmental Authority having jurisdiction over any
such party or any such party’s Property and such default could reasonably be expected to
result in a Material Adverse Effect;

     (m) Borrower or any of its Subsidiaries shall claim—or any court shall find or
rule—that Lender does not have a valid Lien on any material portion of the Collateral;

     (n) Borrower or any of its Subsidiaries shall have concealed, removed, or permitted to
be concealed or removed, any part of its Property, with intent to hinder, delay or defraud
any of its creditors, or made or suffered a transfer of any of its Property which may be
fraudulent under any bankruptcy, fraudulent conveyance or similar law, or shall have made
any transfer of its Property to or for the benefit of a creditor at a time when other
creditors similarly situated have not been paid, or, while insolvent, shall have suffered or
permitted any creditor to obtain a lien upon any of its Property through legal proceedings
or distraint which is not vacated within 30 days from its date; or

     (o) Borrower or any of its Subsidiaries fails to pay when due any amount which he or it
is liable to pay to the PBGC or its successor regarding a Plan or to a Plan,

44

 

or notice of intent to terminate any Plan is filed under ERISA, or PBGC commences
proceedings under ERISA to terminate any Plan or to cause a trustee to be appointed to
administer any Plan, or a proceeding is commenced by any fiduciary of any Plan to enforce
Section 515 or Section 4219(c)(5) of ERISA, or PBGC becomes entitled to obtain a decree
adjudicating that any Plan must be terminated.

     Section 7.02 Remedies. Upon the occurrence of any Event of Default that is then
continuing, Lender shall have the right, at its option, (a) to declare the Commitment terminated
(whereupon the Commitment shall be terminated) and to declare the unpaid balance of the
Indebtedness evidenced by the Note and all other Credit Documents to be immediately due and payable
without further notice (including notice of intent to accelerate and notice of acceleration),
protest or demand or presentment for payment, all of which are hereby expressly waived by Borrower,
and/or (b) to enforce or avail itself of any and all powers, rights and remedies available at law
or provided in this Agreement, the Note, the other Credit Documents or any other document executed
pursuant hereto or in connection herewith. Notwithstanding any provision in this Section to the
contrary, upon the occurrence of any Event of Default that is then continuing, Lender shall have
the right, immediately and without notice, to take possession of and exercise possessory rights
with regard to any Collateral. All powers, rights and remedies of Lender set forth in this Section
shall be cumulative and not exclusive of any other power, right or remedy available to Lender under
the law or under this Agreement, the Note, the other Credit Documents or any other document
executed pursuant hereto or in connection herewith to enforce the performance or observance of the
covenants and agreements contained in this Agreement, and no delay or omission of Lender to
exercise any power, right or remedy accruing to Lender shall impair any such power, right or
remedy, or shall be construed to be a waiver of the right to exercise any such power, right or
remedy. Every power, right or remedy of Lender set forth in this Agreement, the Note, the other
Credit Documents or any other document executed pursuant hereto or in connection herewith, or
afforded by law may be exercised from time to time, and as often as may be deemed expedient by
Lender. In the event that Borrower or any of its Subsidiaries is the subject of any insolvency,
bankruptcy, receivership, dissolution, reorganization or similar proceeding, federal or state,
voluntary or involuntary, under any present or future law or act, Lender is entitled to the
automatic and absolute lifting of any automatic stay as to the enforcement of its remedies under
the Credit Documents against the security for the Indebtedness evidenced by the Note and other sums
due and payable to Lender under any of the Credit Documents, including specifically the stay
imposed by Section 362 of the United States Federal Bankruptcy Code, as amended. Borrower hereby
consents to the immediate lifting of any such automatic stay, and will not contest any motion by
Lender to lift such stay. Borrower expressly acknowledges that the security for such Indebtedness
is not now and will never be necessary to any plan of reorganization of any type.

     Section 7.03 Lender’s Right to Cure. If Borrower or any of its Subsidiaries should
fail to comply with any of its material agreements, covenants or obligations under any Credit
Document, then Lender (in the name of Borrower or its applicable Subsidiary or in Lender’s own
name) may perform them or cause them to be performed for Borrower’s account and at Borrower’s
expense, but shall have no obligation to perform any of them or cause them to be performed. Any
and all reasonable expenses thus incurred or paid by Lender shall be Borrower’s obligations to
Lender due and payable on demand, and each shall bear interest from the date Lender pays it until
the date

45

 

Borrower repays it to Lender at the Default Rate. Upon making any such payment or incurring
any such expense, Lender shall be fully and automatically subrogated to all of the rights of the
person, corporation or body politic receiving such payment. Any amounts owing by Borrower to
Lender pursuant to this or any other provision of this Agreement shall be secured by all
instruments securing the Note. The amount and nature of any such expense and the time when it was
paid shall be fully established by the affidavit of Lender or any of Lender’s officers or agents.
The exercise of the privileges granted to Lender in this Section shall in no event be considered or
constitute a cure of the default or a waiver of Lender’s right at any time after an Event of
Default that is then continuing to declare the Note to be at once due and payable, but is
cumulative of such right and of all other rights given by this Agreement, the Note and the Credit
Documents and of all rights given Lender by law.

ARTICLE VIII

Miscellaneous

     Section 8.01 Usury Not Intended; Savings Provisions. Notwithstanding any provision
to the contrary contained in any Credit Document, it is expressly provided that in no case or event
shall the aggregate of any amounts accrued or paid pursuant to this Agreement which under
applicable laws are or may be deemed to constitute interest ever exceed the maximum nonusurious
interest rate permitted by applicable Texas or federal laws, whichever permit the higher rate. In
this connection, Borrower and Lender stipulate and agree that it is their common and overriding
intent to contract in strict compliance with applicable usury laws. In furtherance thereof, none
of the terms of this Agreement shall ever be construed to create a contract to pay, as
consideration for the use, forbearance or detention of money, interest at a rate in excess of the
maximum rate permitted by applicable laws. Neither Borrower nor any of its Subsidiaries shall ever
be liable for interest in excess of the maximum rate permitted by applicable laws. If, for any
reason whatever, such interest paid or received during the full term of the applicable Indebtedness
produces a rate which exceeds the maximum rate permitted by applicable laws, Lender shall credit
against the principal of such Indebtedness (or, if such Indebtedness shall have been paid in full,
shall refund to the payor of such interest) such portion of said interest as shall be necessary to
cause the interest paid to produce a rate equal to the maximum rate permitted by applicable laws.
All sums paid or agreed to be paid to Lender for the use, forbearance or detention of money shall,
to the extent required to avoid or minimize usury and to the extent permitted by applicable law, be
amortized, prorated, allocated and spread throughout the full term of the applicable Indebtedness
so that the interest rate does not exceed the Ceiling Rate. The provisions of this Section shall
control all agreements, whether now or hereafter existing and whether written or oral, between
Borrower and Lender.

     Section 8.02 Documentation Requirements. Each written instrument required by this
Agreement, the Note or the other Credit Documents to be furnished to Lender shall be duly executed
by the person or persons specified (or where no particular person is specified, by such person as
Lender shall require), duly acknowledged where reasonably required by Lender and, in the case of
affidavits and similar sworn instruments, duly sworn to and subscribed before a notary public duly
authorized to act by governmental authority; shall be furnished to Lender in one or more copies as
required by Lender; and shall in all respects be in form and substance satisfactory to Lender and
to its legal counsel.

46

 

     Section 8.03 Credit Documents Cumulative. The benefits, rights and remedies of Lender
and the security contained herein or provided for in the Note, the other Credit Documents or any
other document executed pursuant hereto or in connection herewith are cumulative; provided,
however, that to the extent of any conflict between any provision of this Agreement and any
provision contained in the Note, the other Credit Documents or any other document executed pursuant
hereto or in connection herewith, the provisions of this Agreement shall control.

     Section 8.04 Satisfaction of Conditions. Where evidence of the existence or
nonexistence of any circumstance or condition is required by this Agreement, the Note, the other
Credit Documents or any other document executed pursuant hereto or in connection herewith to be
furnished to Lender, such evidence shall in all respects be in form and substance satisfactory to
Lender, and the duty to furnish such evidence shall not be considered satisfied until Lender shall
have acknowledged that it is satisfied therewith.

     Section 8.05 Survival. All covenants, agreements, representations and warranties made
by Borrower in this Agreement, the Note, the other Credit Documents and any other document executed
pursuant hereto or in connection herewith, and in any certificates or other documents or
instruments delivered pursuant to this Agreement, the Note, the other Credit Documents or any other
document executed pursuant hereto or in connection herewith shall survive the execution and
delivery of this Agreement, the Note, the other Credit Documents and the other documents executed
pursuant hereto or in connection herewith, and shall continue in full force and effect until full
payment of the Indebtedness evidenced by the Note and/or secured by the Credit Documents, complete
performance of all of the obligations of Borrower and its Subsidiaries under the Credit Documents
and final termination of Lender’s obligations—if any—to make any further advances under the Note
or to provide any other financial accommodation to Borrower or any of its Subsidiaries
(provided, however, that all reimbursement obligations, indemnification and hold
harmless obligations and other similar obligations of Borrower under any of the Credit Documents
shall survive such payment, performance and termination). All such covenants, agreements,
representations and warranties shall be binding upon any successors and assigns of Borrower, but
any attempted assignment of any rights of Borrower hereunder without the prior written consent of
Lender shall be null and void. No Person other than Borrower shall have any right or action hereon
or any rights to Loans at any time, the Loans shall not constitute a trust fund for the benefit of
any third parties and no third party shall under any circumstances have or be entitled to any Lien
or any trust impressed on any undisbursed Loans.

     Section 8.06 Borrower Agrees to Pay or Reimburse Lender’s Expenses. To the extent not
prohibited by applicable law and except as otherwise expressly limited herein, Borrower will pay
all of the following costs and expenses and reimburse Lender for any and all of the following
expenditures incurred or expended from time to time, regardless of whether a Default or an Event of
Default shall have occurred, in connection with:

     (a) all reasonable out-of-pocket costs and expenses for (i) the preparation,
negotiation, documentation, closing, renewal, revision, modification, increase, review or
restructuring of any loan or credit facility secured by the Credit Documents, including
legal, accounting, auditing, architectural, engineering and inspection services and

47

 

disbursements, and (ii) Lender’s creating and perfecting its Liens against the
Collateral; and

     (b) all costs and expenses of realizing upon Lender’s Liens on the Collateral, and all
costs and expenses relating to Lender’s exercising any of its rights and remedies under any
Credit Document or at law and/or protecting the Collateral, including all such appraisal
fees, consulting fees, filing fees, taxes, brokerage fees and commissions, title review and
abstract fees, litigation report fees, UCC search fees, other fees and expenses incident to
title searches, reports and security interests, escrow fees, attorneys’ fees, legal
expenses, court costs, other fees and expenses incurred in connection with any complete or
partial liquidation of the Collateral, and all such fees and expenses for any professional
services relating to the Collateral or any operations conducted in connection therewith.
Provided, that no right or option granted by Borrower to Lender or otherwise arising
pursuant to any provision of any Credit Document shall be deemed to impose or admit a duty
on Lender to supervise, monitor or control any aspect of the character or condition of the
Collateral or any operations conducted in connection therewith for the benefit of Borrower
or any person or entity other than Lender. Borrower agrees to indemnify, defend and hold
Lender, its shareholders, directors, officers, agents, attorneys, advisors and employees
(collectively “Indemnified Parties”) harmless from and against any and all
Environmental Liabilities and any and all other loss, liability, obligation, damage,
penalty, judgment, claim, deficiency, expense, action, suit, cost and disbursement of any
kind or nature whatsoever (including interest, penalties, attorneys’ fees and amounts paid
in settlement), REGARDLESS OF WHETHER CAUSED IN WHOLE OR IN PART BY THE NEGLIGENCE OF ANY OF
THE INDEMNIFIED PARTIES, imposed on, incurred by or asserted against the Indemnified Parties
growing out of or resulting from any Credit Document or any transaction or event
contemplated therein (except that such indemnity shall not be paid to any Indemnified Party
to the extent that such loss, etc. directly results from the gross negligence or willful
misconduct of that Indemnified Party). If any person or entity (including Borrower or any
of its affiliates) ever alleges gross negligence or willful misconduct by an Indemnified
Party, the full amount of indemnification provided for in this Section shall nonetheless be
paid upon demand, subject to later adjustment or reimbursement at such time—if any—as a
court of competent jurisdiction enters a final judgment as to the extent and effect of the
alleged gross negligence or willful misconduct. Any amount to be paid under this Section by
Borrower to Lender shall be a demand obligation owing by Borrower to Lender and shall bear
interest from the date of expenditure until paid at the Default Rate.

     Section 8.07 Amendments in Writing. This Agreement shall not be changed orally but
shall be changed only by agreement in writing signed by Borrower and Lender. Any waiver or consent
with respect to this Agreement shall be effective only in the specific instance and for the
specific purpose for which given. No course of dealing between the parties, no usage of trade and
no parol or extrinsic evidence of any nature shall be used to supplement or modify any of the terms
or provisions of this Agreement.

48

 

     Section 8.08 Notices. Any notice, request or other communication required or
permitted to be given hereunder shall be given in writing by delivering it against receipt for it,
by depositing it with an overnight delivery service or by depositing it in a receptacle maintained
by the United States Postal Service, postage prepaid, registered or certified mail, return receipt
requested, addressed to the respective parties at the addresses shown herein (and if so given,
shall be deemed given when mailed). Borrower’s or Lender’s address for notice may be changed at
any time and from time to time, but only after ten (10) days’ advance written notice to the other
party and shall be the most recent such address furnished in writing by the applicable party to the
other party hereto. Actual notice, however and from whomever given or received, shall always be
effective when received. Whenever (and if) notice by telecopy by Borrower is permitted hereunder,
it is intended for the convenience of Borrower, and Lender may rely on, and shall not be liable for
acting (or refraining from acting) upon, any notice, instruction or request purporting to have been
signed or presented by the proper party unless such action (or refraining from action) constitutes
gross negligence or willful misconduct.

     Section 8.09 Gender; “Including” is Not Limiting; Section Headings. The masculine and
neuter genders used in this Agreement each includes the masculine, feminine and neuter genders, and
whenever the singular number is used, the same shall include the plural where appropriate, and
vice versa. Wherever the term “including” or a similar term is used in this
Agreement, it shall be read as if it were written “including by way of example only and without in
any way limiting the generality of the clause or concept referred to.” The headings used is this
Agreement are included for reference only and shall not be considered in interpreting, applying or
enforcing this Agreement.

     Section 8.10 Lender’s Offset Rights. Lender is hereby authorized at any time and from
time to time, without notice to any person or entity (and Borrower hereby WAIVES any such notice)
to the fullest extent permitted by law, to set-off and apply any and all monies, securities and
other Properties of Borrower now or in the future in the possession, custody or control of Lender,
or on deposit with or otherwise owed to Borrower by Lender—including all such monies, securities
and other Properties held in general, special, time, demand, provisional or final accounts or for
safekeeping or as collateral or otherwise (but excluding those accounts clearly designated as
escrow or trust accounts held by Borrower for others unaffiliated with Borrower)—against any and
all of Borrower’s obligations to Lender now or hereafter existing under this Agreement,
irrespective of whether Lender shall have made any demand under this Agreement. Lender agrees to
use reasonable efforts to promptly notify Borrower after any such set-off and application,
provided that failure to give—or delay in giving—any such notice shall not affect the
validity of such set-off and application or impose any liability on Lender. Lender’s rights under
this Section are in addition to other rights and remedies (including other rights of set-off) which
Lender may have.

     Section 8.11 Governing Law; Venue. This Agreement and the other Credit Documents are
performable in Travis County, Texas. Any legal proceeding in respect of this Agreement or the
other Credit Documents shall be brought exclusively in the district courts of Travis County, Texas
or the United States District Court for the Western District of Texas, Austin Division
(collectively, the “Specified Courts”), to the exclusion of all other venues. Borrower and
Lender hereby irrevocably submit to the exclusive jurisdiction of such state and federal courts of
the State of Texas. Each of Borrower and Lender hereby irrevocably waives, to the fullest extent
permitted by law, any

49

 

objection which it may now or hereafter have to the laying of venue of any suit, action or
proceeding arising out of or relating to any Credit Document brought in any Specified Court, and
hereby further irrevocably waives any claims that any such suit, action or proceeding brought in
any such court has been brought in an inconvenient forum. Each of Borrower and Lender further
irrevocably consents to the service of process out of any of the Specified Courts in any such suit,
action or proceeding by the mailing of copies thereof by certified mail, return receipt requested,
postage prepaid, to the applicable party at its address as provided in this Agreement or as
otherwise provided by Texas law. Each of Borrower and Lender agrees that a final judgment in any
such action or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on
the judgment or in any other manner provided by law. THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE APPLICABLE LAWS OF THE STATE OF TEXAS AND THE UNITED STATES OF
AMERICA FROM TIME TO TIME IN EFFECT.

     Section 8.12 Rights Cumulative; Delay Not Waiver. Lender’s exercise of any right,
benefit or privilege under any of the Credit Documents or any other papers or at law or in equity
shall not preclude the concurrent or subsequent exercise of Lender’s other present or future
rights, benefits or privileges. The remedies provided in this Agreement are cumulative and not
exclusive of any remedies provided by law, the Credit Documents or any other papers. No failure by
Lender to exercise, and no delay in exercising, any right under any Credit Document or any other
papers shall operate as a waiver thereof.

     Section 8.13 Severability. If any provision of this Agreement is held to be illegal,
invalid or unenforceable under present or future laws, the legality, validity and enforceability of
the remaining provisions of this Agreement shall not be affected thereby, and this Agreement shall
be liberally construed so as to carry out the intent of the parties to it. Each waiver in this
Agreement is subject to the overriding and controlling rule that it shall be effective only if and
to the extent that (a) it is not prohibited by applicable law and (b) applicable law neither
provides for nor allows any material sanctions to be imposed against Lender.

     Section 8.14 Entire Agreement. This Agreement, the Note and the other Credit
Documents together embody the entire agreement and understanding between Borrower and Lender with
respect to the subject matter hereof and supersede all prior conflicting or inconsistent
agreements, consents and understandings relating to such subject matter. Borrower acknowledges and
agrees that there is no oral agreement between Borrower and Lender which has not been incorporated
in this Agreement, the Note and the other Credit Documents.

     Section 8.15 Counterparts. This Agreement may be executed in several identical
counterparts, and by the parties hereto on separate counterparts, and each counterpart, when so
executed and delivered, shall constitute an original instrument, and all such separate counterparts
shall constitute but one and the same instrument.

     Section 8.16 Sale and Assignment. Lender reserves the right, in its sole discretion,
without notice to Borrower or any other Person, to sell participations or assign its interest, or
both, in all or any part of this Agreement, the Note, any of the other Credit Documents, any Loan
and the

50

 

Commitment and to disseminate to Lender’s Affiliates, potential purchasers, derivative
counterparties and rating agencies any information it has pertaining to the Loans, including
without limitation, complete and current credit information on Borrower and any of its
Subsidiaries. In the event of any such assignment, Borrower will agree (and will cause each of its
Subsidiares to agree) to such modifications to this Agreement and the other Credit Documents, and
will cause to be delivered to Lender any legal opinion and other Credit Documents, as required to
facilitate such assignment, so long as the same do not modify, alter or increase in any material
respect the obligations and liabilities of Borrower under the Credit Documents. Without limiting
the foregoing, and notwithstanding anything contained in any Credit Document to the contrary,
Lender may at any time assign all or any portion of its rights under this Agreement, the Note and
the other Credit Documents as collateral to a Federal Reserve Bank.

     Section 8.17 JURY TRIAL WAIVER. EACH OF BORROWER AND LENDER HEREBY AGREES NOT TO
ELECT A TRIAL BY JURY OF ANY ISSUE TRIABLE OF RIGHT BY JURY, AND WAIVES ANY RIGHT TO TRIAL BY JURY
FULLY TO THE EXTENT THAT ANY SUCH RIGHT SHALL NOW OR HEREAFTER EXIST WITH REGARD TO THIS AGREEMENT
OR ANY OTHER CREDIT DOCUMENT, OR ANY CLAIM, COUNTERCLAIM OR OTHER ACTION ARISING IN CONNECTION
THEREWITH. THIS WAIVER OF RIGHT TO TRIAL BY JURY IS GIVEN KNOWINGLY AND VOLUNTARILY BY BORROWER
AND LENDER, AND IS INTENDED TO ENCOMPASS INDIVIDUALLY EACH INSTANCE AND EACH ISSUE AS TO WHICH THE
RIGHT TO A TRIAL BY JURY WOULD OTHERWISE ACCRUE. BORROWER AND LENDER ARE EACH HEREBY AUTHORIZED TO
FILE A COPY OF THIS SECTION IN ANY PROCEEDING AS CONCLUSIVE EVIDENCE OF THIS WAIVER BY BORROWER AND
LENDER.

     Section 8.18 USA Patriot Act. Lender is subject to the requirements of the USA
Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Act”) and hereby
notifies Borrower that pursuant to the requirements of the Act, it is required to obtain, verify
and record information that identifies Borrower, which information includes the name and address of
Borrower and other information that will allow Lender to identify Borrower in accordance with the
Act.

NOTICE PURSUANT TO TEX. BUS. & COMM. CODE §26.02

     THIS AGREEMENT, THE NOTE AND THE OTHER CREDIT DOCUMENTS AND ALL OTHER CREDIT DOCUMENTS
EXECUTED BY ANY OBLIGOR AND LENDER OR BY ANY OBLIGOR IN FAVOR OF LENDER SUBSTANTIALLY CONCURRENTLY
HEREWITH CONSTITUTE A WRITTEN LOAN AGREEMENT WHICH REPRESENTS THE FINAL AGREEMENT BETWEEN OBLIGORS
AND LENDER AND MAY NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS OR SUBSEQUENT ORAL
AGREEMENTS OF OBLIGORS AND LENDER. THERE ARE NO UNWRITTEN ORAL AGREEMENTS BETWEEN OBLIGORS AND
LENDER.

[Remainder of page left intentionally blank]

51

 

EXECUTED effective as of the date first set forth above.

	 	 	 	 	 	 	 
	 	 	LUMINEX CORPORATION,

a Delaware corporation	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ David S. Reiter	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	David S. Reiter	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	Vice President, General Counsel and
Corporate Secretary	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Borrower’s Address:	 	 
	 
	 	 	 	 	 	 
	 	 	12212 Technology Boulevard

Austin, Texas 78727 

Attention: Chief Financial Officer	 	 
	 
	 	 	 	 	 	 
	 	 	JPMORGAN CHASE BANK, N.A.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Pritchett	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	James Pritchett	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	Vice President	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Lender’s Address:	 	 
	 
	 	 	 	 	 	 
	 	 	Mail Code TX3-8229

221 West 6th Street, 2nd Floor

Austin, Texas 78701

(P. O. Box 550

Austin, Texas 78767-0550)

Attention: Manager/Commercial Lending Group
	 	 

EXHIBITS:

Exhibit A — Request for Loan

Exhibit B – Rate Selection Notice

Exhibit C – Borrowing Base Certificate

Exhibit D – Compliance Certificate

52Ex-10.8

 

EXHIBIT 10.8

SUMMARY
OF NAMED EXECUTIVE OFFICER AND NON-EMPLOYEE DIRECTOR COMPENSATION

Named
Executive Officer Compensation

On January
29, 2007, after consideration of presentations and recommendations of management and
independent compensation consultants, and such other matters and information as deemed appropriate,
the Compensation Committee (the “Committee”) of the Board of Directors of the Company approved the
following bonuses for 2006 and set the following salaries for 2007 for the named executive officers
set forth in the table below:

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Amount of	 	Amount of
	Executive Officer	 	Title	 	2006 Bonus	 	2007 Salary
	David H. Lissy
	 	CEO	 	$	400,000	 	 	$	310,000	 
	Mary Ann Tocio
	 	President and COO	 	$	400,000	 	 	$	310,000	 
	Elizabeth J. Boland
	 	CFO and Treasurer	 	$	120,000	 	 	$	230,000	 
	Stephen I. Dreier
	 	CAO and Secretary	 	$	70,000	 	 	$	206,400	 

Cash Incentive Plan. The Committee adopted a cash incentive plan for named
 executive officers for
2007 (the “Bonus Plan”). Pursuant to the Bonus Plan, each named executive officer is eligible for
an annual target cash bonus award equal to the percentage of annual salary set forth in the table
below (the “Base Bonus”). In addition to the Base Bonus, the Chief Executive Officer and President
and Chief Operating Officer are eligible to receive up to 150% of the Base Bonus for significant
overachievement of performance expectations (the “Incremental Bonus”), providing the Chief
Executive Officer and President and Chief Operating Officer with a maximum bonus potential of up to
120% of their annual salary.

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Base Bonus	 	Incremental Bonus	 	Qualitative Bonus
	Executive Officer	 	(% of 2007 Salary)	 	(% of 2007 Salary)	 	(% of total bonus)
	David H. Lissy
	 	 	80	%	 	 	40	%	 	 	+/- 20	%
	Mary Ann Tocio
	 	 	80	%	 	 	40	%	 	 	+/- 20	%
	Elizabeth J. Boland
	 	 	60	%	 	 	N/A	 	 	 	N/A	 
	Stephen I. Dreier
	 	 	35	%	 	 	N/A	 	 	 	N/A	 

NON-EMPLOYEE
DIRECTOR COMPENSATION

            Annual Retainer and Equity Awards.  Each non-employee director receives an Annual Board
Retainer of $10,000, 50% of which is payable in cash at the quarterly rate of $1,250, and 50% of which is
payable in the form of an annual grant of restricted share units as of each annual shareholder meeting date.
The number of units granted to each director will be determined by dividing $5,000 by the fair market
value of the Company’s common stock on the trading date immediately preceding the date of the award.
The units will vest immediately, but will be restricted as to
conversion into shares of the Company’s
common stock until such time as the non-employee director completes
his or her service on the Board.

             In addition, non-employee Directors receive a grant of 2,000 options as of the date of each annual
meeting, provided that a Director has attended at least 75% of the Board and Committee meetings that he or
she was required to attend.  These options vest 100% at the end of a three-year period and expire at the end
of seven years.

            Meeting Fees. Each non-employee director receives $2,500 for each regularly scheduled Board
meeting attended in person or $1,000 for each regularly scheduled Board meeting attended by conference
call, and $500 for each specially scheduled meeting attended in
person or by conference call.

            Each member of the Compensation Committee also receives $1,000 for each committee meeting
attended in person or $500 for each committee meeting attended by conference call.  Additionally, the chair
of the Compensation Committee receives an annual retainer of
$5,000.

            Each member of the Audit Committee also receives $1,500 for each committee meeting attended
in person or $750 for each committee meeting attended by conference call.  Additionally, the chair of the
Audit Committee receives an annual retainer of $10,000.

            Each member of the Nominating and Governance Committee also receives $1,000 for each
committee meeting attended in person or $500 for each committee meeting attended by conference call.
Additionally, the chair of the Nominating and Governance Committee receives an annual retainer of
$2,500.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00118-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00118-of-00352.parquet"}]]