Document:

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COMMON STOCK                                                        COMMON STOCK
   NUMBER                                                              SHARES

                                   DYAX CORP.

                                   DYAX CORP.

              INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE

                                                     CUSIP  26746E  10  3
                                             SEE REVERSE FOR CERTAIN DEFINITIONS

THIS CERTIFIES THAT

is the owner of

    FULLY PAID AND NON ASSESSABLE SHARES OF COMMON STOCK, $.01 PAR VALUE, OF

DYAX CORP. (hereinafter called the "Corporation"), transferable on the books of
the Corporation by the holder hereof in person or by duly authorized attorney,
upon surrender of this certificate properly endorsed. This certificate and the
shares represented hereby are issued and shall be held subject to all the
provisions of the laws of the State of Delaware, the Restated Certificate of
Incorporation and Restated By-Laws of the Corporation and all amendments
thereto, to which the holder of this certificate by acceptance hereof assents.

This Certificate is not valid until countersigned by the Transfer Agent and
registered by the Registrar.

WITNESS the facsimile seal of the Corporation and the facsimile signatures of
its duly authorized officers.

                           Dated:

SEAL

------------------------------           --------------------------------
          PRESIDENT                                  TREASURER

                                         Countersigned and Registered
                                         AMERICAN STOCK TRANSFER & TRUST COMPANY

                                                 New York, NY

                                                            Transfer Agent
                                                            and Registrar

                                         By
                                           -------------------------------------
                                                            Authorized Signature

                                       1

<PAGE>

         THE CORPORATION IS AUTHORIZED TO ISSUE MORE THAN ONE CLASS OR SERIES OF
STOCK. THE CORPORATION WILL FURNISH WITHOUT CHARGE TO ANY STOCKHOLDER, UPON
REQUEST, A STATEMENT OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE
PARTICIPATING, OPTIONAL, OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR
SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH
PREFERENCES AND/OR RIGHTS.

         The following abbreviations, when used in the inscription on the face
of this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

<TABLE>
<S>        <C>                           <C>
TEN COM -  as tenants in common          UNIF GIFT MIN ACT - _____________ Custodian ______________
TEN ENT -  as tenants by the entireties                           (Cust)               (Minor)
JT TEN  -  as joint tenants with
           right of survivorship and                   under Uniform Gifts to Minors
           not as tenants in common
                                                       Apt_______________________________________
                                                                          (State)
</TABLE>

     Additional abbreviations may also be used though not in the above list.

         For value received, __________________________ hereby sell, assign and
         transfer unto

         PLEASE INSERT SOCIAL SECURITY OR OTHER
         IDENTIFYING NUMBER OF ASSIGNEE

         ------------------------------------------------

--------------------------------------------------------------------------------
  (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
                                                                          shares
--------------------------------------------------------------------------

of the capital stock represented by the within Certificate, and do hereby
irrevocably constitute and appoint

                                                                        Attorney
------------------------------------------------------------------------

to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.

         Dated
               ------------------------

        ------------------------------------------------------------------------
NOTICE: THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS
        WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT
        ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.

SIGNATURE(S) GUARANTEED:

--------------------------------------------------------------------------------
THE SIGNATURE SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION, (BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN
AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE
17Ad-15.

                                       2<PAGE>

                                                                   EXHIBIT 10.16

                                   AMENDMENT
                                       TO
                            OPTION AGREEMENTS I & II

                                    BETWEEN

                                 ADAPTEC, INC.

                                      AND

                  TAIWAN SEMICONDUCTOR MANUFACTURING CO., LTD.

                                JANUARY 1, 1999

* Portions of this document have been omitted and filed separately with the
Securities and Exchange Commission pursuant to a request for confidential
treatment

<PAGE>

                                   AMENDMENT
                                   ---------

     THIS AMENDMENT is made and becomes effective as of January 1, 1999 (the
"Effective Date") by Taiwan Semiconductor Manufacturing Co., Ltd. ("TSMC", a
company organized under the laws of the Republic of China with its registered
address at No. 121, Park Ave. 3, Science Based Industrial Park, Hsinchu,
Taiwan, and Adaptec, Manufacturing (s) Pts. Ltd., a company organized under the
laws of Singapore with its registered address at 6 Battery Road, 532-00,
Singapore, 049909. ("Customer").

RECITALS

     WHEREAS, TSMC currently supplies Customers with wafers and Customer wishes
to maintain TSMC's guarantee to continue to supply the wafers;

     WHEREAS, Parties wish to amend the terms of the Option Agreements I and II
as set forth herein;

AGREEMENT

     NOW, THEREFORE, in consideration of the mutual covenants and conditions
contained herein, the parties agree as follows:

1. DEFINITIONS

     (a) All definitions under Option Agreements I and II remain the same
         excepted where stated herein.

     (b) "Wafer Equivalent" used in this Amendment shall mean the number of
         six-inch wafers based on the equivalency factor for 1998 Bass Capacity.
         For details of the equivalency factor, please refer to Exhibit A, which
         will be amended from time to time. Any and all capacity commitments
         referred to in this Amendment shall be measured in wafer Equivalent.

2. VOLUME COMMITMENT

     All terms and conditions pertaining to this section remain the same as set
     forth in Option Agreements I and II except where stated herein. The new
     volume commitment is listed in Exhibit B.

                                        2

<PAGE>

3.  WAFER PRICE

    All terms and conditions pertaining to this section remain the same as set
    forth in Option Agreements I and II except where stated herein. TSMC agrees
    to refund to the Customer in the amount of USD 5,414,080.00 for the
    overpayment in the calendar year 1998 based on the Option Agreements I and
    II for the calendar year 1998. TSMC shall distribute the refund in four (4)
    equal installments to the Customer on January 31, 1999, April 30, 1999,
    July 31, 1999, and October 31, 1999 respectively.

4.  OTHER PURCHASE TERMS AND CONDITIONS

    All terms and conditions pertaining to this section remain the same as set
    forth in Option Agreements I and II and Amendment No. 2 to the Foundry
    Agreement effective as of 21st April, 1997.

5.  OBLIGATION TO PAY OPTION FEE FOR OPTION CAPACITY

    All terms and conditions pertaining to this section remain the same as set
    forth in Option Agreement II except the amount for the Option Fee shall be
    $33.6M.

6.  FAILURE TO PURCHASE THE OPTION CAPACITY; FIRST RIGHT OF REFUSAL

    All terms and conditions pertaining to this section remain the same as set
    forth in Option Agreements I and II.

7.  TERM AND TERMINATION

    All terms and conditions pertaining to this section remain the same as set
    forth in Option Agreements I and II except that the expiration of this
    Amendment shall be December 31, 2002.

8.  BOARD APPROVAL

    Customer shall obtain the approval by its board of director of this
    Amendment, and submit to TSMC, at the time of executing this Amendment, an
    authentic copy of its board resolution authorizing the representative
    designated below to execute this Amendment.

                                        3
<PAGE>

9.   LIMITATION OF LIABILITY

     All terms and conditions pertaining to this section remain the same as set
     forth in Option Agreements I and II.

10.  NOTICE

     All terms and conditions pertaining to this section remain the same as set
     forth in Option Agreements I and II.

11.  ENTIRE AGREEMENT

     This Amendment together with the Option Agreements I and II, including
Exhibits A-D attached hereto, constitute the entire Agreement between the
parties with respect to the subject matter hereof, and supersedes and replaces
all prior or contemporaneous understandings, agreements, dealings and
negotiations, oral or written, regarding the subject matter hereof. No
modification, alteration or amendment of this Agreement shall be effective
unless in writing and signed by both parties. No waiver of any breach or failure
by either party to enforce any provision of this Agreement shall be deemed a
waiver of any other or subsequent breach, or a waiver of future enforcement of
that or any other provision.

12.  GOVERNING LAW

     This Agreement will be governed by and interpreted in accordance with the
laws of the State of California.

13.  ARBITRATION

     All terms and conditions pertaining to this section remain the same as set
forth in Option Agreements I and II.

14.  ASSIGNMENT

     All terms and conditions pertaining to this section remain the same as set
forth in Option Agreements I and II.

                                        4

<PAGE>

15.  CONFIDENTIALITY

     All terms and conditions pertaining to this section remain the same as set
     forth in Option Agreement I and II.

16.  FORCE MAJEURE

     All terms and conditions pertaining to this section remain the same as set
     forth in Option Agreements I and II.

     IN WITNESS WHEREOF, the parties, have executed this Agreement as of the
     date first stated above.

TAIWAN SEMICONDUCTOR                      ADAPTEC MANUFACTURING(S)
MANUFACTURING CO., LTD.                   Ptd. Ltd.

By:  [Signature illegible]                By: /s/ Sam Kazarian
   ---------------------------------         --------------------------------
Name: [Signature illegible]                   Sam Kazarian
     -------------------------------         --------------------------------
Title: Sr. V.P. of TSM Ltd.                   Director and Attorney-In-Fact
      ------------------------------         --------------------------------

                                        5
<PAGE>

                                   EXHIBIT A
                             CAPACITY FACTOR TABLE

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------
                                     MASKING
                                    LAYERS(A)
                                   (W/O ESD OR      W-PLUG       COMPLEXITY     CAPACITY
GENERIC TECHNOLOGY                  POLYLMIDE)     LAYERS(B)      INDEX(C)      FACTOR(D)
-----------------------------------------------------------------------------------------
<S>                                <C>             <C>           <C>            <C>
1.5um SPDM (BICMOS)                     *                             *             *
1.2um SPDM (Logic)                      *                             *             *
1.0um SPDM (Logic)                      *                             *             *
1.0um DPDM (BICMOS)                     *                             *             *
0.8um SPDM (Logic)                      *                             *             *
0.8um DPDM (MixMode)                    *                             *             *
0.8um SPTM (Logic Salicide)             *                             *             *
0.8um DPDM (BICMOS)                     *                             *             *
0.6um SPDM (Logic)                      *              *              *             *
0.6um SPTM (Logic)                      *              *              *             *
0.6um DPDM (Mix Mode)                   *              *              *             *
0.6um DPDM (SRAM)                       *                             *             *
0.6um TPSM (DRAM)                       *              *              *             *
0.6um QPDM (DRAM)                       *              *              *             *
0.5um SPDM (Logic)                      *              *              *             *
0.5um SPTM (Logic SACVD)                *              *              *             *
0.5um SPTM (Logic-CMP)                  *              *              *             *
0.5um DPDM (SRAM)                       *              *              *             *
0.5um QPDM (DRAM)                       *              *              *             *
0.35um SPTM (Logic-CMP)                 *              *              *             *
-----------------------------------------------------------------------------------------
</TABLE>

Remarks:  (1) Masking Layer of w/f ESD (or Polylmide) = Masking Layer of w/o ESD
              (or Polylmide) + 1
          (2) Masking Layer of Mixed-Mode(DP) = Masking Layer of Logic(EP) + 1
          (3) Completely Index (C) = (A) + (B)/2
          (4) Capacity Factor (D) = (C)/13, normalized to 0.8um SPDM as 1

Date of issue: 6/9/95

NOTE: This table shall be amended from time to time to reflect the update of
the technology.

* Confidential information has been omitted and filed separately with the
  Securities and Exchange Commission pursuant to a request for confidential
  treatment.

                                        6

<PAGE>

                                                                       EXHIBIT B

                        CUSTOMER/TSMC COMMITTED CAPACITY

                          UNIT: K 6" WAVER EQUIVALENT
                          ---------------------------

<TABLE>
<CAPTION>
                                   1999      2000      2001      2002
                                   ----      ----      ----      ----
<S>                                <C>       <C>       <C>       <C>
Base Capacity
  (For Options)                     [*]       [*]       [*]        [*]

X% of Base Capacity                 [*]       [*]       [*]        [*]

Option                              [*]       [*]       [*]        [*]

TSMC Committed Capacity
  (Base Capacity +
  Option Capacity)                  [*]       [*]       [*]        [*]

Customer Committed Capacity
  (X% Base Capacity +
  Option Capacity)                  [*]       [*]       [*]        [*]

Option Capacity [*] wafers x [*] per wafer = U.S. $33.6M

Remaining from Deposits for Options I and II: U.S. $33.6M
</TABLE>

* Confidential information has been omitted and filed separately with the
  Securities and Exchange Commission pursuant to a request for confidential
  treatment.

                                        7
<PAGE>
                                                                       EXHIBIT C

                            INTENTIONALLY LEFT BLANK

                                        8
<PAGE>
                                                                      EXHIBIT D

                                   OPTION FEE

<TABLE>
<CAPTION>
                    Option Capacity
                     (Unit: Wafer            Option Fee
Year                  Equivalent)            (Unit: US$)         Due Date
----                ---------------          -----------         --------
<S>                 <C>                      <C>                 <C>
1999                      [*]                  $ 8.4M              Paid

2000                      [*]                  $ 8.4M              Paid

2001                      [*]                  $ 8.4M              Paid

2002                      [*]                  $ 8.4M              Paid
</TABLE>

[*] Confidential information has been omitted and filed separately with the
    Securities and Exchange Commission pursuant to a request for confidential
    treatment.

                                        9

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