Document:

Exhibit 4.50

 

 

NOTE PURCHASE AGREEMENT

 

This Note Purchase Agreement (this “Agreement”)
is made as of June 24, 2016 (the “Effective Date”) by and among Amyris, Inc., a Delaware corporation (the “Company”),
and the individuals or entities listed on Schedule I hereto (each, a “Purchaser,” and collectively, the
“Purchasers”).

 

Preliminary Statement

 

Subject to the terms and conditions hereof,
each Purchaser desires to purchase, and the Company desires to offer and sell to each Purchaser, that aggregate principal amount
of Secured Promissory Notes with a principal amount set forth opposite each such Purchaser’s name on Schedule I hereto
(which aggregate principal amount for all Purchasers as of the Closing (as defined below) shall be $5,000,000) (each such Secured
Promissory Note, a “Note” and collectively, the “Notes”). If and when issued, each of the
Notes shall be evidenced by a promissory note in the form attached hereto as Exhibit A.

 

Agreement

 

The parties, intending to be legally
bound, agree as follows:

 

1.
Sale of Notes. Subject to the terms and conditions hereof, at the Closing (as defined in Section 2), the Company
shall sell to each Purchaser, and, subject to satisfaction of the conditions set forth in this Agreement, each such Purchaser will
purchase from the Company, (i) a Note in a principal amount as set forth next to such Purchaser’s name on Schedule I
hereto for a purchase price equal to the purchase price set forth next to such Purchaser’s name on Schedule I hereto
under the column “Note Purchase Price” (the “Purchase Price”). The sale and purchase of the Notes
to each Purchaser shall constitute a separate sale and purchase hereunder.

 

2.
Closing. The closing (“Closing”) of the transactions contemplated hereby shall be held
at the offices of Fenwick & West LLP, 801 California Street, Mountain View, California 94041 within one business day following
the date on which the last of the conditions set forth in Sections 7 and 8 have been satisfied or waived in accordance with this
Agreement but in no event later than June 30, 2016 (such date, the “Closing Date”), or at such other time and
place as the Company and the Purchasers mutually agree upon.

 

3.Delivery.

 

(a) At the Closing, each Purchaser shall (i)
pay the Company the applicable Purchase Price in immediately available funds, or (ii) (A) initiate irrevocable payment instructions
to its paying bank to make the payment (an “Irrevocable Payment Instruction”) to the Company of the applicable
Purchase Price in immediately available funds and (B) deliver to the Company confirmation that such Purchaser has made an Irrevocable
Payment Instruction, such confirmation to be in the form of a federal reference number or other similar written evidence that a
wire has been initiated.

 

     

     

    

(b) At the Closing, or, if applicable, upon
receipt of the applicable amount of the Purchase Price due in respect of the Closing from any Purchaser who makes an Irrevocable
Payment Instruction at the Closing, the Company shall deliver to such Purchaser a Note with a principal amount as provided in Section
1 above, such Note to be registered in the name of such Purchaser, or in such nominee’s or nominees’ name(s) as provided
by such Purchaser to the Company, against payment of the Purchase Price therefor as provided in Section 1 above by wire transfer
of immediately available funds to such account or accounts as the Company shall designate in writing to such Purchaser at least
two (2) days prior to the date of the Closing.

 

4.Company Representations.
The Company represents and warrants to the Purchasers as follows:

 

(a) Organization and Standing. The
Company is duly incorporated, validly existing, and in good standing under the laws of the State of Delaware. The Company has all
requisite power and authority to own and operate its properties and assets and to carry on its business as presently conducted
and as proposed to be conducted. The Company is qualified to do business as a foreign entity in every jurisdiction in which the
failure to be so qualified would have, or would reasonably be expected to have, a material adverse effect, individually or in the
aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations, prospects, financial condition
or results of operation of the Company or the ability of the Company to perform its obligations under this Agreement (a “Material
Adverse Effect”). For the purposes of clarity, the implementation of any plan for the significant restructuring of the
Company, which has been approved by the Board of Directors of the Company as of the date hereof, shall not constitute a Material
Adverse Effect.

 

(b) Power. The Company has all requisite
power to execute and deliver this Agreement, to sell and issue the Notes hereunder, and to carry out and perform its obligations
under the terms of this Agreement and the Notes (collectively, the “Transaction Agreements”).

 

(c) Authorization. Subject to any waivers
of covenants limiting the Company’s ability to incur further debt under outstanding debt instruments and loans, each of which
would be obtained or waived as required prior to the Closing (the “Pre-Closing Consents”), the execution, delivery,
and performance of the Transaction Agreements by the Company has been duly authorized by all requisite action on the part of the
Company and its officers, directors and stockholders, and this Agreement and the Notes constitute the legal, valid, and binding
obligation of the Company enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency,
reorganization, moratorium, and other laws of general application affecting enforcement of creditors’ rights generally, and
(b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies (together,
the “Enforceability Exceptions”).

 

(d) Consents and Approvals.
Except for any Current Report on Form 8-K or other document to be filed by the Company with the U.S. Securities and Exchange
Commission (the “SEC”) in connection with the transactions contemplated hereby, the Company is not
required to give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or
governmental agency in order to consummate the transactions contemplated hereby. Assuming the accuracy of the representations
of the Purchasers in Section 5, no consent, approval, authorization or other order of, or registration, qualification or
filing with, any court, regulatory body, administrative agency, self-regulatory organization, stock exchange or market
(including The NASDAQ Stock Market LLC (“The NASDAQ Stock Market”), or other governmental body is required
for the execution and delivery of the Transaction Agreements, the valid issuance, sale and delivery of the Notes to be sold
pursuant to this Agreement other than such as have been made or obtained, or for any securities filings required to be made
under federal or state securities laws applicable to the offering of the Notes.

 

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(e) Non-Contravention. The execution
and delivery of this Agreement and, following satisfaction of the Closing conditions set forth in Sections 7 and 8 hereof as applicable
to the Closing, the issuance, sale and delivery of the Notes to be sold by the Company under this Agreement and the performance
by the Company of its obligations under the Transaction Agreements and/or the consummation of the transactions contemplated thereby,
will not (a) conflict with, result in the breach or violation of, or constitute (with or without the giving of notice or the passage
of time or both) a violation of, or default under, (i) subject to obtaining the Pre-Closing Consents, any bond, debenture, note
or other evidence of indebtedness, or under any lease, license, franchise, permit, indenture, mortgage, deed of trust, loan agreement,
joint venture or other agreement or instrument to which the Company or any subsidiary is a party or by which it or its properties
may be bound or affected, (ii) the Company’s Restated Certificate of Incorporation, as amended and as in effect on the date
hereof, the Company’s Bylaws, as amended and as in effect on the date hereof, or the equivalent document with respect to
any subsidiary, as amended and as in effect on the date hereof, or (iii) any statute or law, judgment, decree, rule, regulation,
ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration
panel or authority applicable to the Company, any of its subsidiaries or their respective properties, except in the case of clauses
(i) and (iii) for such conflicts, breaches, violations or defaults that would not be likely to have, individually or in the aggregate,
a Material Adverse Effect, or (b) except for any security interests granted pursuant to the Notes, result in the creation or imposition
of any lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of the
Company or any of its subsidiaries or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained
in any material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust
or any other agreement or instrument to which the Company or any if its subsidiaries is a party or by which the Company or any
of its subsidiaries is bound or to which any of the property or assets of the Company is subject. For purposes of this Section
4(e), the term “material” shall apply to agreements, understandings, instruments, contracts or proposed transactions
to which the Company is a party or by which it is bound involving obligations (contingent or otherwise) of, or payments to, the
Company in excess of $100,000 in a 12-month period.

 

(f) Notes. The Notes have been duly
authorized by the Company and, when duly executed and delivered and paid for as provided herein, will be duly and validly issued
and outstanding and will constitute valid and legally binding obligations of the Company enforceable against the Company in accordance
with their terms, subject to the Enforceability Exceptions. The issuance and delivery of each of the Notes is not subject to preemptive,
co-sale, right of first refusal or any other similar rights of the stockholders of the Company or any other person, or any liens
or encumbrances or result in the triggering of any anti-dilution or other similar rights under any outstanding securities of the
Company.

 

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(g) No Registration. Assuming the accuracy
of each of the representations and warranties of the Purchaser herein, the issuance by the Company of the Notes is exempt from
registration under the Securities Act of 1933, as amended (the “Securities Act”).

 

(h) Reporting Status. The Company is
subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”),
and, as of the Closing, will have filed all documents and reports that the Company was required to file pursuant to Section I.A.3.b
of the General Instructions to Form S-3 promulgated under the Securities Act in order for the Company to be eligible to use Form
S-3 (the foregoing materials, together with any materials filed by the Company under the Exchange Act, whether or not required,
collectively, the “SEC Documents”). The SEC Documents complied as to form in all material respects with requirements
of the Securities Act and Exchange Act and the rules and regulations of the SEC promulgated thereunder (collectively, the “SEC
Rules”), and none of the SEC Documents and the information contained therein, as of their respective filing dates, contained
any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order
to make the statements therein, in light of the circumstances under which they were made, not misleading. As used in this Agreement,
“Previously Disclosed” means information set forth in or incorporated by reference into the SEC Documents filed
with the SEC on or after November 9, 2015 but prior to the date hereof (except for risks and forward-looking information set forth
in the “Risk Factors” section of the applicable SEC Documents or in any forward-looking statement disclaimers or similar
statements that are similarly non-specific and are predictive or forward-looking in nature).

 

(i) Legal Proceedings. Except as Previously
Disclosed, there is no action, suit or proceeding before any court, governmental agency or body, domestic or foreign, now pending
or, to the knowledge of the Company, threatened against the Company or its subsidiaries wherein an unfavorable decision, ruling
or finding would reasonably be expected to, individually or in the aggregate, (i) materially adversely affect the validity or enforceability
of, or the authority or ability of the Company to perform its obligations under, the Transaction Agreements or (ii) have a Material
Adverse Effect. The Company is not a party to or subject to the provisions of any injunction, judgment, decree or order of any
court, regulatory body, administrative agency or other governmental agency or body that might have, individually or in the aggregate,
a Material Adverse Effect.

 

(j) No Violations. Neither the
Company nor any of its subsidiaries is in violation of its respective certificate of incorporation, bylaws or other
organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation,
ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency,
arbitration panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the
aggregate, would be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries is
in default (and there exists no condition which, with or without the passage of time or giving of notice or both, would
constitute a default) in the performance of any bond, debenture, note or any other evidence of indebtedness in any indenture,
mortgage, deed of trust or any other material agreement or instrument to which the Company or any of its subsidiaries is a
party or by which the Company or any of its subsidiaries is bound or by which the properties of the Company are bound, which
would be reasonably likely to have a Material Adverse Effect. There has not been, and to the knowledge of the Company, there
is not pending or contemplated, any investigation by the SEC involving the Company or any current or former director or
officer of the Company and the Company is not an “ineligible issuer” pursuant to Rules 164, 405 and 433 under the
Securities Act. The Company has not received any comment letter from the SEC relating to any SEC Documents which has not been
resolved. The SEC has not issued any stop order or other order suspending the effectiveness of any registration statement
filed by the Company under the Exchange Act or the Securities Act.

 

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(k) Listing Compliance. The Company
is in compliance with the requirements of The NASDAQ Stock Market for continued listing of the Common Stock thereon and has no
knowledge of any facts or circumstances that could reasonably lead to delisting of its Common Stock from The NASDAQ Stock Market.
The Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock
under the Exchange Act or the listing of the Common Stock on The NASDAQ Stock Market, nor has the Company received any notification
that the SEC or The NASDAQ Stock Market is contemplating terminating such registration or listing. The transactions contemplated
by the Transaction Agreements will not contravene the rules and regulations of The NASDAQ Stock Market.

 

(l) Financial Statements. The consolidated
financial statements of the Company and its subsidiaries and the related notes thereto included in the SEC Documents (the “Financial
Statements”) comply in all material respects with applicable accounting requirements and the rules and regulations of
the SEC with respect thereto as in effect at the time of filing and present fairly, in all material respects, the financial position
of the Company and its subsidiaries as of the dates indicated and the results of its operations and cash flows for the periods
therein specified subject, in the case of unaudited statements, to normal year-end audit adjustments. Except as set forth in such
Financial Statements (or the notes thereto), such Financial Statements (including the related notes) have been prepared in accordance
with U.S. generally accepted accounting principles applied on a consistent basis throughout the periods therein specified (“GAAP”).
Except as set forth in the Financial Statements, neither the Company nor its subsidiaries has any material liabilities other than
liabilities and obligations that have arisen in the ordinary course of business and which would not be required to be reflected
in financial statements prepared in accordance with GAAP.

 

(m) Disclosure. The Company understands
and confirms that the Purchasers will rely on the foregoing representations in effecting transactions in the Notes. All disclosure
furnished by or on behalf of the Company to the Purchasers in connection with this Agreement regarding the Company, its business
and the transactions contemplated hereby is true and correct in all material respects and does not contain any untrue statement
of a material fact or omit to state any material fact necessary in order to make the statements made therein, in light of the circumstances
under which they were made, not misleading. The Company acknowledges and agrees that the Purchasers have not made and do not make
any representations or warranties with respect to the transactions contemplated hereby other than those set forth in Section 5
hereto.

 

5. Investment Representations.
In connection with the receipt of the Notes, each Purchaser represents and warrants to the Company the following:

 

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(a) Organization. Purchaser is duly
organized, validly existing, and in good standing under the laws of the jurisdiction of its organization.

 

(b) Power. Purchaser has all requisite
power to execute and deliver this Agreement and to carry out and perform its obligations under the terms of this Agreement.

 

(c) Authorization. The execution, delivery,
and performance of this Agreement by Purchaser has been duly authorized by all requisite action, and this Agreement constitutes
the legal, valid, and binding obligation of Purchaser enforceable in accordance with its terms (subject to the Enforceability Exceptions).

 

(d) Consents and Approvals. Purchaser
need not give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government or governmental
agency in order to consummate the transactions contemplated by this Agreement.

 

(e) Non-Contravention. The execution,
delivery and, subject to satisfaction by the Company of the conditions to Closing set forth in Sections 7 and 8 hereof on or prior
to the issuance of the Notes, or performance, by Purchaser of this Agreement do not and will not contravene or constitute a default
under, or violation of, or be subject to penalties under, (i) any agreement (or require the consent of any party under any such
agreement that has not been made or obtained) to which Purchaser is a party, or (ii) any judgment, injunction, order, decree or
other instrument binding upon Purchaser, except where such contravention, default, violation or failure to obtain a consent, individually
or in the aggregate, would not reasonably be expected to impair Purchaser’s ability to perform fully any obligation which
Purchaser has or will have under this Agreement.

 

(f) Investor Qualification. Purchaser
understands the definition of the term “accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated
by the SEC under the Securities Act, and qualifies as an accredited investor.

 

(g) Information; Purchase for Investment
Only. Purchaser is aware of the Company’s business affairs and financial condition and has acquired sufficient information
about the Company to reach an informed and knowledgeable decision to acquire the Notes. Purchaser is acquiring the Notes for investment
for its own account only and not with a view to, or for resale in connection with, any “distribution” thereof within
the meaning of the Securities Act or under any applicable provision of state law. Purchaser does not have any present intention
to transfer the Notes to any other person or entity in such a “distribution.”

 

(h) No Registration. Purchaser understands
that the Notes have not been registered under the Securities Act by reason of a specific exemption therefrom, which exemption depends
upon, among other things, the bona fide nature of Purchaser’s investment intent as expressed herein.

 

(i) Restricted Securities.
Purchaser understands that the Notes are “restricted securities” under applicable U.S. federal and state
securities laws and that, pursuant to these laws, Purchaser must hold the Notes indefinitely unless they are registered with
the SEC and qualified by state authorities, or an exemption from such registration and qualification requirements is
available. Purchaser acknowledges that the Company has no obligation to register or qualify the Notes for resale.

 

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(j) Risk of Investment. Purchaser realizes
that the purchase of the Notes will be a highly speculative investment and Purchaser may suffer a complete loss of its investment.
Purchaser understands all of the risks related to the purchase of the Notes. By reason of its business and financial experience,
Purchaser has the ability to protect its own interests in connection with the purchase of the Notes.

 

(k) Advisors. Purchaser has reviewed
with its own tax advisors the federal, state, and local tax consequences of this investment and the transactions contemplated by
this Agreement. Purchaser acknowledges that it has had the opportunity to review this Agreement and the transactions contemplated
hereby with Purchaser’s own legal counsel.

 

(l) Finder. Purchaser is not obligated
and will not be obligated to pay any broker commission, finders’ fee, success fee, or commission in connection with the transactions
contemplated by this Agreement.

 

6.
Restrictive Legends and Stop-Transfer Orders. The Notes shall bear such legends as the Company deems to be
required for the purpose of compliance with applicable federal or state securities laws or as otherwise required by law.

 

7.
Conditions to Company’s Obligations at the Closing. The Company’s obligation to complete the sale
and issuance of the Notes, and deliver the Notes to the Purchasers at the Closing shall be subject to the following conditions
to the extent not waived by the Company:

 

(a) Receipt of Payment. The Company
shall have received payment (or confirmation that an Irrevocable Payment Instruction has been made with respect to such payment),
by wire transfer of immediately available funds or by cancellation of indebtedness of the Company to each applicable Purchaser,
in the full amount of the Purchase Price for the Notes being purchased by such Purchaser at the Closing.

 

(b) Representations and Warranties.
The representations and warranties made by the Purchasers in Section 5 hereof shall be true and correct in all material respects
as of, and as if made on, the date of such Closing.

 

(c) Subordination Agreement. The Purchasers
shall have executed and delivered to the Company the Subordination Agreement (as defined in Section 9(b)(ii) hereof).

 

8. Conditions to Purchaser’s
Obligations at the Closing. Each Purchaser’s obligation to accept delivery of the Notes and to pay for such Purchaser’s
respective Notes at the Closing shall be subject to the following conditions to the extent not waived by such Purchaser:

 

(a) Representations and Warranties.
The representations and warranties made by the Company in Section 4 hereof shall be true and correct in all material respects (except
for any representations and warranties which are qualified as to materiality, which shall be true and correct in all respects)
as of, and as if made on, the date of this Agreement and as of the date of the Closing as though such representations and warranties
were made on and as of such date.

 

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(b) Certificate. The Purchaser shall
have received a certificate dated as of the Closing and signed by the Company’s Chief Executive Officer and Chief Financial
Officer to the effect that the representations and warranties of the Company in Section 4 hereof are true and correct in all material
respects (except for any representations and warranties which are qualified as to materiality, which shall be true and correct
in all respects) as of, and as if made on, the date of this Agreement and as of the Closing, and that the Company has satisfied
all of the conditions set forth in this Agreement and required to be satisfied as of the Closing.

 

(c) Good Standing. The Company shall
be validly existing as a corporation in good standing under the laws of Delaware as evidenced by a certificate of the Secretary
of State of the State of Delaware, a copy of which shall be provided to the Purchaser at the Closing.

 

(d) Board Approval. The terms and conditions
of the issuance of the Notes and the Transaction Agreements shall have been duly approved by the Board of Directors of the Company
(including the Audit Committee and at least six directors who are disinterested with respect to the transactions contemplated hereby).

 

(e) Other Approvals. The Company shall
have obtained all governmental, regulatory or third party consents and approvals required in connection with the transactions contemplated
hereby, if any, including obtaining the Pre-Closing Consents and any waivers of any other negative covenants and pro rata or similar
preemptive rights that may apply to the issuance of the Notes.

 

9. Other Agreements 

 

(a) SEC Filings. Upon execution of
this Agreement and the issuances of Notes, the Company will complete any SEC filings (such as a Current Report on Form 8-K) that
are, in the judgment of the Company’s legal counsel, required to be completed.

 

(b) Security Interest.

 

(i) As security for the prompt, complete
and indefeasible payment when due (whether on the payment dates or otherwise) of all the Company’s obligations under the
Notes, including any obligation to pay any amount now owning or later arising under the Notes (collectively, the “Secured
Obligations”), the Company grants to each Purchaser a second priority security interest in all of the Company’s right,
title, and interest in and to the Collateral (as defined in that certain Loan and Security Agreement dated as of March 29, 2014,
as amended on June 12, 2014, March 31, 2015 and November 30, 2015 (as amended, the “LSA”) by and between the
Company, and each of its subsidiaries that has delivered a Joinder Agreement (as defined in the LSA), the other financial institutions
or entities from time to time parties to the LSA (collectively, referred to as “Lender”) and Stegodon Corporation,
a Delaware corporation, as assignee of Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent
for itself and the Lender (in such capacity, the “Agent”)), as limited by Section 3.2 of the LSA.

 

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(ii) The Company hereby agrees to enter
into any additional Security Documents (as defined below) with the Purchasers as may be reasonably required by the Purchasers in
connection with the grant of the security interest contemplated by Section 9(b)(i) hereof, provided, however, that such security
interest shall be subject to the Subordination Agreement dated as of June 24, 2016, by and among the Purchasers, the Company and
the Agent (the “Subordination Agreement”). As used herein, “Security Documents” means each
security agreement, all other mortgages, deeds of trust, security agreements, pledge agreements, assignments, control agreements,
financing statements and other documents as shall from time to time secure or relate to the Secured Obligations or any part thereof,
in each case, executed by the Company or any subsidiary of the Company.

 

10. Miscellaneous. 

 

(a) Governing Law. This Agreement and
all acts and transactions pursuant hereto and the rights and obligations of the parties hereto shall be governed, construed and
interpreted in accordance with the laws of the State of California, without giving effect to principles of conflicts of law.

 

(b) Assignment; Successors and Assigns.
This Agreement may not be assigned by the Purchaser without the prior written consent of the Company; provided, that this
Agreement may be assigned by a Purchaser to the valid transferee of any security purchased hereunder if such security remains a
“restricted security” under the Securities Act. This Agreement and all provisions thereof shall be binding upon, inure
to the benefit of, and are enforceable by the parties hereto and their respective successors and permitted assigns.

 

(c) Notices.
All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received
(i) when personally delivered, (ii) when sent by facsimile upon confirmation of receipt, (iii) one business day after the day on
which the same has been delivered prepaid to a nationally recognized courier service, or (iv) five business days after the deposit
in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case addressed, as to the
Company, to Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number: 
, with a copy to Fenwick & West LLP, 801 California Street, Mountain View, CA 94041, Attn: Dan Winnike, Esq., facsimile number:
(650) 938-5200, and as to each Purchaser at the address and facsimile number set forth opposite such Purchaser’s name on
the Schedule of Purchasers on Schedule I. Any party hereto from time to time may change its address, facsimile number, or
other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto.
The Purchasers and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic
communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular
notices or communications.

 

(d) Severability. In the event
that any provision of this Agreement or the application of any provision hereof is declared to be illegal, invalid, or
otherwise unenforceable by a court of competent jurisdiction, the remainder of this Agreement shall not be affected except to
the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision held invalid shall
substantially impair the benefits of the remaining portions of this Agreement.

 

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(e) Headings. The headings in this
Agreement are for convenience of reference only and shall not constitute a part of this Agreement, nor shall they affect its meaning,
construction, or effect.

 

(f) Entire Agreement. This Agreement
embodies the entire understanding and agreement between the parties hereto with respect to the subject matter hereof and supersedes
all prior agreements and understandings relating to the subject matter hereof.

 

(g) Expenses. Each party will bear
its own costs and expenses in connection with this Agreement.

 

(h) Further Assurances. The parties
agree to execute and deliver all such further documents, agreements and instruments and take such other and further action as may
be necessary or appropriate to carry out the purposes and intent of this Agreement.

 

(i) Counterparts. This Agreement may
be executed in two or more counterparts, each of which shall constitute an original, but all of which, when taken together, shall
constitute but one instrument, and shall become effective when one or more counterparts have been signed by each party hereto and
delivered to the other party. Facsimile signatures shall be deemed originals for all purposes hereunder.

 

(j) Amendments and Waivers. This Agreement
may not be amended, supplemented or otherwise modified except in a written instrument executed by the Company and the holders of
a majority of the aggregate principal amount of the then outstanding Notes. No waiver by any of the parties of any default, misrepresentation,
or breach of warranty or covenant hereunder, whether intentional or not, shall be deemed to extend to any prior or subsequent default,
misrepresentation, or breach of warranty or covenant hereunder or affect in any way any rights arising by virtue of any prior or
subsequent such occurrence. No waiver by any of the parties of any of the provisions hereof shall be effective unless explicitly
set forth in writing and executed by the party sought to be charged with such waiver. No action taking pursuant to this Agreement,
including any investigation by or on behalf of any party, shall be deemed to constitute a waiver by the party taking such action
of compliance with any representation, warranty, covenant or agreement contained herein. No failure on the part of any party to
exercise, and no delay in exercising, any right, power or remedy hereunder shall operate as a waiver thereof, nor shall any single
or partial exercise of such right, power or remedy by such party preclude any other or further exercise thereof or the exercise
of any other right, power or remedy.

 

 

[Signature Pages Follow]

 

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The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	 	THE COMPANY:
	 	 	 
	 	 	AMYRIS, INC.
	 	 	 
	 	 	By:  	/s/ Raffi Asadorian
	 	 	 	(Signature)
	 	 	 	 
	 	 	Name: 	Raffi Asadorian
	 	 	 	 
	 	 	Title: 	Chief Financial Officer
	 	 	 
	 	 	Address:
	 	 	58855 Hollis Street, Suite 100
	 	 	Emeryville, CA 94608
	 	 	Attention: General Counsel
	 	 	Facsimile: (510) 899-0165
	 	 	Email:

 

 

 

 

[Signature Page to Note Purchase Agreement]

     

     

    

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	 	PURCHASER:
	 	 	 
	 	 	FORIS VENTURES, LLC
	 	 	 
	 	 	By:  	/s/ Barbara Hager
	 	 	 	(Signature)
	 	 	 	 
	 	 	Name: 	Barbara Hager
	 	 	 	 
	 	 	Title: 	Manager

 

 

 

 

 

 

[Signature Page to Note Purchase Agreement]

     

     

    

 

SCHEDULE I

 

Schedule of Purchasers

 

Closing: June 24, 2016

 

	Name of Purchaser	Notes Principal Amount	Note Purchase Price	Address and Facsimile
	Foris Ventures LLC	$5,000,000	$5,000,000	
        Foris Ventures, LLC Attention: Barbara S. Hager JEMA Management LLC 751 Laurel St. #717
        San Carlos, CA 940703113 Phone: 650-384-0244 Fax: 650-384-0254

         

	
        TOTAL

         
	
        $5,000,000

         
	
        $5,000,000

         
	
         

         

 

 

     

     

    

EXHIBIT A

 

FORM OF NOTE

 

 

 

 

 

 

 

 

     

     

    

SECURED PROMISSORY NOTE 

 

	U.S.$_______________	 	Issue Date: June [●], 2016

 

THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR APPLICABLE STATE SECURITIES LAWS, AND
MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED, TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH
LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY
THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE, AND THE COMPANY'S AND HOLDER’S RIGHTS AND OBLIGATIONS
HEREUNDER, IS SUBJECT TO A SUBORDINATION AGREEMENT BETWEEN THE ORIGINAL HOLDER HEREOF, THE COMPANY, THE CREDITORS PARTY THERETO
AND STEGODON CORPORATION, AS AGENT, DATED AS OF THE ISSUE DATE. IN THE EVENT OF ANY INCONSISTENCY BETWEEN THIS NOTE AND THE SUBORDINATION
AGREEMENT, THE TERMS OF THE SUBORDINATION AGREEMENT WILL CONTROL.

 

Subject to the terms and conditions of this
Note, for value received, Amyris, Inc., a Delaware corporation (the “Company”), hereby promises to pay
to the order of [Insert Investor Name] or registered assigns (“Holder”),
the principal sum of [Insert Investment Amount] Dollars ($_________),
or such lesser amount as shall then equal the outstanding principal amount hereunder, together with interest accrued on the unpaid
principal amount at the Applicable Rate. Interest shall begin to accrue on the Issue Date set forth above, shall continue to accrue
on the outstanding principal until the entire Balance is paid, and shall be computed based on the actual number of days elapsed
and on a year of 365 days.

 

This Note was issued pursuant to the Note Purchase
Agreement, dated as of June 24, 2016 (as amended from time to time, the “Agreement”), by and among the
Company, the original holder of this Note and the other parties thereto and is subject to provisions of the Agreement. Capitalized
terms used but not otherwise defined herein shall have the meaning given to such terms in the Agreement.

 

The following is a statement of the rights of
Holder and the terms and conditions to which this Note is subject, and to which the Holder hereof, by the acceptance of this Note,
agrees.

 

Notwithstanding anything to the contrary,
this Note is subordinated to certain other indebtedness of the Company on the terms and restrictions set forth in the
Subordination Agreement.

 

     

     

    

1. DEFINITION. The following definitions
shall apply for purposes of this Note.

 

“Affiliate” has the
meaning ascribed to it in Rule 144 promulgated under the Securities Act.

 

“Applicable Rate”
means a rate equal to the lower of: (a) the Highest Lawful Rate; and

(b) thirteen and one half percent (13.5%) per annum.

 

“Balance” means, at
the applicable time, the sum of all then outstanding principal of this Note, all then accrued but unpaid interest and all other
amounts then accrued but unpaid under this Note.

 

“Board of Directors”
means the Company’s Board of Directors.

 

“Business Day” means
a weekday on which banks are open for general banking business in San Francisco, California.

 

“Capital Lease Obligation”
means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would
at such time be required to be capitalized on a balance sheet in accordance with GAAP.

 

“Change of Control”
shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company with
or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale, lease,
transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the assets
of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the merger
of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons”
that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or
indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly or indirectly,
Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving
or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company; (iii)
the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any
“person” becomes the “beneficial owner” directly or indirectly, of more than 50% of the Voting Shares of
the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of the members of
the Board of Directors does not consist of Continuing Directors.

 

“Company” shall include,
in addition to the Company identified in the opening paragraph of this Note, any corporation or other entity which succeeds to
the Company’s obligations under this Note, whether by permitted assignment, by merger or consolidation, operation of law
or otherwise.

 

“Continuing Director”
shall mean, as of any date of determination, any member of the Board of Directors who (i) was a member of the Board of Directors
on the Issue Date or (ii) was nominated for election or elected to the Board of Directors with
the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination
or election and who voted with respect to such nomination or election; provided that a majority of the members of the Board of
Directors voting with respect thereto shall at the time have been Continuing Directors.

 

     

     

    

“Debt” shall mean,
with respect to any Person, any indebtedness of such Person, whether or not contingent, in respect of borrowed money or evidenced
by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof) or banker’s
acceptances or representing Capital Lease Obligations or the balance deferred and unpaid of the purchase price of any property
or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable, if and to
the extent any of the foregoing indebtedness (other than letters of credit and Hedging Obligations) would appear as a liability
upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien on any asset
of such Person (whether or not such Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise included, the
Guarantee by such Person of any Debt of any other Person. The amount of any Debt outstanding as of any date shall be (i) the accreted
value thereof, in the case of any Debt that does not require current payments of interest or (ii) the principal amount thereof,
together with any interest thereon that is more than 30 days past due, in the case of any other Debt.

 

“Event of Default” has
the meaning set forth in Section 5.

 

“Financing Document” means
each of this Note, the Notes, the Agreement and any other document entered into, executed or delivered under or in connection with,
or for the purpose of amending, any of such documents.

 

“GAAP” means generally
accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such
other statements by such other entity as have been approved by a significant segment of the accounting profession in the United
States, which are in effect from time to time.

 

“Hedging Obligations”
means, with respect to any Person, the obligations of such Person under (i) currency exchange or interest rate swap agreements,
interest rate cap agreements and interest rate collar agreements and (ii) other agreements or arrangements designed to protect
such Person against fluctuations in interest rates or currency exchange rates.

 

“Highest Lawful Rate”
means the maximum non-usurious rate of interest, as in effect from time to time, which may be charged, contracted for, reserved,
received or collected by Holder in connection with this Note under applicable law.

 

“Lease Debt”
means, with respect to any Person, (i) the amount of any accrued and unpaid obligations of such Person arising under any
lease or related document (including a purchase agreement, conditional sale or other title retention agreement) in connection
with the lease of real property or improvement thereon (or any personal property included as part of any such lease) which
provides that such Person is contractually obligated to purchase or cause a third party to purchase the leased property or
pay an agreed upon residual value of the leased property to the lessor (whether or not such lease transaction is
characterized as an operating lease or a capitalized lease in accordance with GAAP) and (ii) the guarantee, direct or
indirect, in any manner (including, without limitation, letters of credit and reimbursement agreements in respect thereof),
of any of the amounts set forth in (i) above.

 

     

     

    

“Lien” means, with
respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in respect of such asset,
whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale or other title retention
agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest in and any filing
of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction).

 

“Lost Note Documentation”
means documentation satisfactory to the Company with regard to a lost or stolen Note, including, if required by the Company, an
affidavit of lost note and an indemnification agreement by Holder in favor of the Company with respect to such lost or stolen Note.

 

“Maturity Date” means
May 15, 2017.

 

“Note” means this
Secured Promissory Note.

 

“Notes” means a series
of secured promissory notes aggregating up to no more than $5,000,000 in original principal amount issued under the Agreement,
of which this Note is one, each such note containing substantially identical terms and conditions as this Note.

 

“Person” means an
individual, corporation, limited liability company, partnership, association, joint-stock company, trust, unincorporated organization,
joint venture or other entity or any governmental authority.

 

“Principal Balance”
means, at the applicable time, all then outstanding principal of this Note.

 

“Subordination Agreement”
means that certain Subordination Agreement dated as of June 24, 2016, by and among the Purchasers, the Company and the Agent.

 

“Subsidiary” means,
with respect to any specified Person: (a) any corporation, association or other business entity of which more than 50% of the total
voting power of shares of capital stock entitled (without regard to the occurrence of any contingency and after giving effect to
any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors,
managers or trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly,
by that Person or one or more of the other Subsidiaries of that Person (or a combination thereof); and (b) any partnership (i)
the sole general partner or the managing general partner of which is such Person or a Subsidiary of such Person or (ii) the only
general partners of which are that Person or one or more Subsidiaries of that Person (or any combination thereof).

 

“Voting Shares”
of any Person means capital shares or capital stock of such Person which ordinarily has voting power for the election of
directors (or Persons performing similar functions) of such Person, whether at all times or only so long as no senior class
of securities has such voting power by reason of any contingency.

 

     

     

    

2. PAYMENT AT MATURITY DATE; INTEREST.

 

2.1 Payment at Maturity Date.

 

(a) If this Note has not been previously
prepaid in full pursuant to Section 3.1 prior to the Maturity Date, then the entire Balance shall be due and payable in full in
cash on the Maturity Date.

 

(b) All rights with respect to this
Note shall terminate upon the repayment of the entire Balance of this Note as provided in Section 2.1(a). Notwithstanding the foregoing,
Holder agrees to surrender this Note to the Company (or Lost Note Documentation where applicable) as soon as practicable after
repayment pursuant to Section 2.1.

 

(c) Notwithstanding anything herein
to the contrary, if during any period for which interest is computed hereunder, the amount of interest computed on the basis provided
for in this Note, together with all fees, charges and other payments which are treated as interest under applicable law, as provided
for herein or in any other document executed in connection herewith, would exceed the amount of such interest computed on the basis
of the Highest Lawful Rate, then the Company shall not be obligated to pay, and Holder shall not be entitled to charge, collect,
receive, reserve or take, interest in excess of the Highest Lawful Rate, and during any such period the interest payable hereunder
shall be computed on the basis of the Highest Lawful Rate.

 

3. PREPAYMENT; CHANGE OF CONTROL.

 

3.1 Prepayment. The Company
may at any time, without penalty, upon at least five (5) days’ advance written notice to Holder, prepay all or any portion
of the unpaid Balance of this Note. Any such prepayment shall be applied as provided in Section 4 below.

 

3.2 hange of Control Payment.
If the Company completes a Change of Control before the payment of the entire Balance of this Note, then upon the closing of such
Change of Control, Holder shall be entitled to be repaid the entire Balance of this Note.

 

3.3 Asset Sales. In the event
that the Company receives proceeds of at least $20 million from an asset sale consummated prior to the Maturity Date, the Note
holders holding at least a majority of the then outstanding principal amount of Notes will have the right to require the Company
to repay the entire Balance of the Notes within sixty (60) days of the Company’s receipt of such proceeds.

 

4. NOTES PARI PASSU; APPLICATION OF
PAYMENTS. Each of the Notes shall rank equally without preference or priority of any kind over one another, and all payments
and recoveries under any other Financing Document payable on account of principal and interest on the Notes shall be paid and applied
ratably and proportionately on the Balances of all outstanding Notes on the basis of their original principal amount. Subject to
the foregoing provisions of this Section, all payments will be applied first
to the repayment of accrued fees and expenses under this Note, then to accrued interest until all then outstanding accrued
interest has been paid in full, and then to the repayment of principal until all principal has been paid in full. If after
all applications of such payments have been made as provided in this Section, then the remaining amount of such payment that is
in either case in excess of the aggregate Balance of all outstanding Notes, shall be returned to the Company.

 

     

     

    

5. EVENTS OF DEFAULT. Each
of the following events shall constitute an “Event of Default” hereunder:

 

(a) The Company fails to make any payment
when due under this Note on the applicable due date or within five (5) days after written notice of such failure has been given
on behalf of Holder to the Company;

 

(b) A receiver is appointed for any
material part of the Company’s property, the Company makes a general assignment for the benefit of creditors, or the Company
becomes a debtor or alleged debtor in a case under the U.S. Bankruptcy Code or becomes the subject of any other bankruptcy or similar
proceeding for the general adjustment of its debts or for its liquidation;

 

(c) The Company breaches any material
obligation to any Holder under this Note and does not cure such breach within twenty (20) days after written notice thereof has
been given by or on behalf of such Holder to the Company;

 

(d) A default under any mortgage, indenture
or instrument under which there may be issued or by which there may be secured or evidenced any Debt for money borrowed by the
Company (or the payment of which is guaranteed by the Company, whether such Debt or guarantee now exists, or is created after the
Issue Date of this Note, which default (a) is caused by a failure to pay principal of or premium, if any, or interest on such Debt
prior to the expiration of the grace period provided in such Debt on the date of such default or (b) results in the acceleration
of such Debt prior to its express maturity and, in each case in clause (a) or (b), the principal amount of any such Debt, together
with the principal amount of any other such Debt that has not been paid when due, or the maturity of which has been so accelerated,
aggregates $10,000,000 or more; or

 

(e) The Company’s Board of Directors
or stockholders adopt a resolution for the liquidation, dissolution or winding up of the Company.

 

Upon the occurrence of any Event of Default, all accrued but unpaid
expenses, accrued but unpaid interest, all principal and any other amounts outstanding under this Note shall (i) in the case of
any Event of Default under Section 5(b), become immediately due and payable in full without further notice or demand by Holder
and (ii) in the case of any Event of Default other than under Section 5(b), become immediately due and payable upon written notice
by or on behalf of all Holder(s) of then outstanding Notes. Notwithstanding any other provision of this Note, Holder agrees that
Holder will exercise Holder’s rights and remedies under this Note only in concert with all other holders of outstanding
Notes and will not take any action, including commencement or prosecution of litigation or any other proceeding to collect this
Note, except as agreed by the holders of a majority of the then outstanding principal amount of the Notes.

 

     

     

    

6. PROVISIONS RELATING TO STOCKHOLDER
RIGHTS. This Note does not entitle Holder to any voting rights or other rights as a stockholder of the Company. No provisions
of this Note and no enumeration herein of the rights or privileges of Holder, shall cause Holder to be a stockholder of the Company
for any purpose.

 

7. REPRESENTATIONS AND WARRANTIES
OF HOLDER. In order to induce the Company to issue this Note to the original Holder, the original Holder has made representations
and warranties to the Company as set forth in the Agreement.

 

8. GENERAL PROVISIONS.

 

8.1 Waivers. The Company and
all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

8.2 Transfer. Neither this Note
nor any rights hereunder may be assigned, conveyed or transferred, in whole or in part, without the Company’s prior written
consent, which the Company may withhold in its sole discretion; provided, however, that this Note may be assigned,
conveyed or transferred without the prior written consent of the Company to any Affiliate of Holder who (a) executes and delivers
an acknowledgement that such transferee agrees to be subject to, and bound by, all the terms and conditions of this Note, (b) makes
the representations and warranties to the Company that are set forth in Section 5 of the Agreement, and (c) (if requested by the
Company) delivers to the Company an opinion of legal counsel, reasonably satisfactory to the Company, that such transfer complies
with state and federal securities laws. Subject to the foregoing, the rights and obligations of the Company and Holder under this
Note shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees.

 

8.3 Governing Law. This Note
shall be governed, construed and interpreted in accordance with the laws of the State of California, without giving effect to principles
of conflicts of law.

 

8.4 Headings. The headings and
captions used in this Note are used only for convenience and are not to be considered in construing or interpreting this Note.
All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached
hereto, all of which exhibits are incorporated herein by this reference.

 

8.5 Notices. All notices, requests,
and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally
delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been
delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States
mail, registered or certified, return receipt requested, postage prepaid, in each case addressed, as to the Company, to Amyris,
Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number:

, with a copy to Fenwick & West LLP, 801
California Street, Mountain View, CA 94041, Attn: Dan Winnike, Esq., facsimile number: , and as to Holder at the address and facsimile
number set forth opposite such Holder’s name on Schedule I to the Agreement or as otherwise indicated by Holder by providing notice
of a change in its address, facsimile number, or other information to the Company. Holder and the Company may each agree in writing
to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably approved
by it; provided that approval of such procedures may be limited to particular notices or communications.

 

     

     

    

8.6 Place of Payment. Payments
of the Principal and any interest and other payments hereunder shall be delivered to the Holder at the address specified in the
Agreement or at such other address or the attention of such other Person as specified by prior written notice to the Company, including
any transferee of this Note.

 

8.7 Amendments and Waivers.
This Note and all other Notes issued under the Agreement may be amended and provisions may be waived by the Note holders holding
at least a majority of the then outstanding principal amount of Notes and the Company as provided in Section 10(j) of the Agreement.
Any amendment or waiver effected in accordance with Section 10(j) of the Agreement shall be binding upon each holder of any Notes
at the time outstanding, each future holder of the Notes and the Company.

 

8.8 Severability. If one or
more provisions of this Note are held to be unenforceable under applicable law, then such provision(s) shall be excluded from this
Note to the extent they are held to be unenforceable and the remainder of the Note shall be interpreted as if such provision(s)
were so excluded and shall be enforceable in accordance with its terms.

 

[Signature page follows] 

 

 

     

     

    

 

IN WITNESS WHEREOF, the Company has caused this Secured Promissory
Note to be signed in its name as of the date first written above.

 

 

	 	 	THE COMPANY
	 	 	 
	 	 	AMYRIS, INC. 
	 	 	 
	 	 	By:  	
	 	 	 	 
	 	 	Name: 	
	 	 	 	 
	 	 	Title:Exhibit 4.51

 

 

SECURED PROMISSORY NOTE

 

	U.S.$5,000,000.00	 	Issue Date: June 24, 2016

 

THE SECURITIES REPRESENTED BY THIS NOTE HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR APPLICABLE STATE SECURITIES LAWS, AND
MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED, TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH
LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY
THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE, AND THE COMPANY'S AND HOLDER’S RIGHTS AND OBLIGATIONS
HEREUNDER, IS SUBJECT TO A SUBORDINATION AGREEMENT BETWEEN THE ORIGINAL HOLDER HEREOF, THE COMPANY, THE CREDITORS PARTY THERETO
AND STEGODON CORPORATION, AS AGENT, DATED AS OF THE ISSUE DATE. IN THE EVENT OF ANY INCONSISTENCY BETWEEN THIS NOTE AND THE SUBORDINATION
AGREEMENT, THE TERMS OF THE SUBORDINATION AGREEMENT WILL CONTROL.

 

Subject to the terms and conditions of this
Note, for value received, Amyris, Inc., a Delaware corporation (the “Company”), hereby promises to pay
to the order of Foris Ventures, LLC or registered assigns (“Holder”), the principal sum of Five Million
Dollars ($5,000,000), or such lesser amount as shall then equal the outstanding principal amount hereunder, together with interest
accrued on the unpaid principal amount at the Applicable Rate. Interest shall begin to accrue on the Issue Date set forth above,
shall continue to accrue on the outstanding principal until the entire Balance is paid, and shall be computed based on the actual
number of days elapsed and on a year of 365 days.

 

This Note was issued pursuant to the Note Purchase
Agreement, dated as of June 24, 2016 (as amended from time to time, the “Agreement”), by and among the
Company, the original holder of this Note and the other parties thereto and is subject to provisions of the Agreement. Capitalized
terms used but not otherwise defined herein shall have the meaning given to such terms in the Agreement.

 

The following is a statement of the rights of
Holder and the terms and conditions to which this Note is subject, and to which the Holder hereof, by the acceptance of this Note,
agrees.

 

Notwithstanding anything to the contrary, this
Note is subordinated to certain other indebtedness of the Company on the terms and restrictions set forth in the Subordination
Agreement.

 

    	-2-

     

    

1.DEFINITION. The following definitions shall apply
for purposes of this Note.

 

“Affiliate” has the
meaning ascribed to it in Rule 144 promulgated under the Securities Act.

 

“Applicable Rate”
means a rate equal to the lower of: (a) the Highest Lawful Rate; and (b) thirteen and one half percent (13.5%) per annum.

 

“Balance” means, at
the applicable time, the sum of all then outstanding principal of this Note, all then accrued but unpaid interest and all other
amounts then accrued but unpaid under this Note.

 

“Board of Directors”
means the Company’s Board of Directors.

 

“Business Day” means
a weekday on which banks are open for general banking business in San Francisco, California.

 

“Capital Lease Obligation”
means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would
at such time be required to be capitalized on a balance sheet in accordance with GAAP.

 

“Change of Control”
shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company with
or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale, lease,
transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the assets
of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the merger
of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons”
that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or
indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly or indirectly,
Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving
or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company; (iii)
the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any
“person” becomes the “beneficial owner” directly or indirectly, of more than 50% of the Voting Shares of
the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of the members of
the Board of Directors does not consist of Continuing Directors.

 

“Company” shall include,
in addition to the Company identified in the opening paragraph of this Note, any corporation or other entity which succeeds to
the Company’s obligations under this Note, whether by permitted assignment, by merger or consolidation, operation of law
or otherwise.

 

“Continuing
Director” shall mean, as of any date of determination, any member of the Board of Directors who (i) was a
member of the Board of Directors on the Issue Date or (ii) was nominated for election or elected to the Board of Directors
with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such
nomination or election and who voted with respect to such nomination or election; provided that a majority of the members of
the Board of Directors voting with respect thereto shall at the time have been Continuing Directors.

 

    	-3-

     

    

“Debt” shall mean,
with respect to any Person, any indebtedness of such Person, whether or not contingent, in respect of borrowed money or evidenced
by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof) or banker’s
acceptances or representing Capital Lease Obligations or the balance deferred and unpaid of the purchase price of any property
or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable, if and to
the extent any of the foregoing indebtedness (other than letters of credit and Hedging Obligations) would appear as a liability
upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien on any asset
of such Person (whether or not such Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise included, the
Guarantee by such Person of any Debt of any other Person. The amount of any Debt outstanding as of any date shall be (i) the accreted
value thereof, in the case of any Debt that does not require current payments of interest or (ii) the principal amount thereof,
together with any interest thereon that is more than 30 days past due, in the case of any other Debt.

 

“Event of Default” has
the meaning set forth in Section 5.

 

“Financing Document” means
each of this Note, the Notes, the Agreement and any other document entered into, executed or delivered under or in connection with,
or for the purpose of amending, any of such documents.

 

“GAAP” means generally
accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such
other statements by such other entity as have been approved by a significant segment of the accounting profession in the United
States, which are in effect from time to time.

 

“Hedging Obligations”
means, with respect to any Person, the obligations of such Person under (i) currency exchange or interest rate swap agreements,
interest rate cap agreements and interest rate collar agreements and (ii) other agreements or arrangements designed to protect
such Person against fluctuations in interest rates or currency exchange rates.

 

“Highest Lawful Rate”
means the maximum non-usurious rate of interest, as in effect from time to time, which may be charged, contracted for, reserved,
received or collected by Holder in connection with this Note under applicable law.

 

“Lease Debt”
means, with respect to any Person, (i) the amount of any accrued and unpaid obligations of such Person arising under any
lease or related document (including a purchase agreement, conditional sale or other title retention agreement) in connection
with the lease of real property or improvement thereon (or any personal property included as part of any such lease) which
provides that such Person is contractually obligated to purchase or cause a third party to purchase the leased property or
pay an agreed upon residual value of the leased property to the lessor (whether or not such lease transaction is
characterized as an operating lease or a capitalized lease in accordance with GAAP) and (ii) the guarantee, direct or
indirect, in any manner (including, without limitation, letters of credit and reimbursement agreements in respect thereof),
of any of the amounts set forth in (i) above.

 

    	-4-

     

    

“Lien” means, with
respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in respect of such asset,
whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale or other title retention
agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest in and any filing
of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction).

 

“Lost Note Documentation”
means documentation satisfactory to the Company with regard to a lost or stolen Note, including, if required by the Company, an
affidavit of lost note and an indemnification agreement by Holder in favor of the Company with respect to such lost or stolen Note.

 

“Maturity Date” means
May 15, 2017.

 

“Note” means this
Secured Promissory Note.

 

“Notes” means a series
of secured promissory notes aggregating up to no more than $5,000,000 in original principal amount issued under the Agreement,
of which this Note is one, each such note containing substantially identical terms and conditions as this Note.

 

“Person” means an
individual, corporation, limited liability company, partnership, association, joint-stock company, trust, unincorporated organization,
joint venture or other entity or any governmental authority.

 

“Principal Balance”
means, at the applicable time, all then outstanding principal of this Note.

 

“Subordination Agreement”
means that certain Subordination Agreement dated as of June 24, 2016, by and among the Purchasers, the Company and the Agent.

 

“Subsidiary” means,
with respect to any specified Person: (a) any corporation, association or other business entity of which more than 50% of the total
voting power of shares of capital stock entitled (without regard to the occurrence of any contingency and after giving effect to
any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors,
managers or trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly,
by that Person or one or more of the other Subsidiaries of that Person (or a combination thereof); and (b) any partnership (i)
the sole general partner or the managing general partner of which is such Person or a Subsidiary of such Person or (ii) the only
general partners of which are that Person or one or more Subsidiaries of that Person (or any combination thereof).

 

“Voting Shares” of
any Person means capital shares or capital stock of such Person which ordinarily has voting power for the election of directors
(or Persons performing similar functions) of such Person, whether at all times or only so long as no senior class of securities
has such voting power by reason of any contingency.

 

    	-5-

     

    

2. PAYMENT AT MATURITY DATE; INTEREST.

 

2.1 Payment at Maturity Date.

 

(a) If this Note has not been previously
prepaid in full pursuant to Section 3.1 prior to the Maturity Date, then the entire Balance shall be due and payable in full in
cash on the Maturity Date.

 

(b) All rights with respect to this
Note shall terminate upon the repayment of the entire Balance of this Note as provided in Section 2.1(a). Notwithstanding the foregoing,
Holder agrees to surrender this Note to the Company (or Lost Note Documentation where applicable) as soon as practicable after
repayment pursuant to Section 2.1.

 

(c) Notwithstanding anything herein
to the contrary, if during any period for which interest is computed hereunder, the amount of interest computed on the basis provided
for in this Note, together with all fees, charges and other payments which are treated as interest under applicable law, as provided
for herein or in any other document executed in connection herewith, would exceed the amount of such interest computed on the basis
of the Highest Lawful Rate, then the Company shall not be obligated to pay, and Holder shall not be entitled to charge, collect,
receive, reserve or take, interest in excess of the Highest Lawful Rate, and during any such period the interest payable hereunder
shall be computed on the basis of the Highest Lawful Rate.

 

3. PREPAYMENT; CHANGE OF CONTROL.

 

3.1 Prepayment. The Company
may at any time, without penalty, upon at least five (5) days’ advance written notice to Holder, prepay all or any portion
of the unpaid Balance of this Note. Any such prepayment shall be applied as provided in Section 4 below.

 

3.2 Change of Control Payment.
If the Company completes a Change of Control before the payment of the entire Balance of this Note, then upon the closing of such
Change of Control, Holder shall be entitled to be repaid the entire Balance of this Note.

 

3.3 Asset Sales. In the event
that the Company receives proceeds of at least $20 million from an asset sale consummated prior to the Maturity Date, the Note
holders holding at least a majority of the then outstanding principal amount of Notes will have the right to require the Company
to repay the entire Balance of the Notes within sixty (60) days of the Company’s receipt of such proceeds.

 

4. NOTES PARI PASSU;
APPLICATION OF PAYMENTS. Each of the Notes shall rank equally without preference or priority of any kind over one
another, and all payments and recoveries under any other Financing Document payable on account of principal and interest on
the Notes shall be paid and applied ratably and proportionately on the Balances of all outstanding Notes on the basis of
their original principal amount. Subject to the foregoing provisions of this Section, all payments will be applied first
to the repayment of accrued fees and expenses under this Note, then to accrued interest until all then outstanding
accrued interest has been paid in full, and then to the repayment of principal until all principal has been paid in
full. If after all applications of such payments have been made as provided in this Section, then the remaining amount of
such payment that is in either case in excess of the aggregate Balance of all outstanding Notes, shall be returned to the
Company.

 

    	-6-

     

    

5. EVENTS OF DEFAULT. Each
of the following events shall constitute an “Event of Default” hereunder:

 

(a) The Company fails to
make any payment when due under this Note on the applicable due date or within five (5) days after written notice of such failure
has been given on behalf of Holder to the Company;

 

(b) A receiver is appointed
for any material part of the Company’s property, the Company makes a general assignment for the benefit of creditors, or
the Company becomes a debtor or alleged debtor in a case under the U.S. Bankruptcy Code or becomes the subject of any other bankruptcy
or similar proceeding for the general adjustment of its debts or for its liquidation;

 

(c) The Company breaches
any material obligation to any Holder under this Note and does not cure such breach within twenty (20) days after written notice
thereof has been given by or on behalf of such Holder to the Company;

 

(d) A default under any
mortgage, indenture or instrument under which there may be issued or by which there may be secured or evidenced any Debt for money
borrowed by the Company (or the payment of which is guaranteed by the Company, whether such Debt or guarantee now exists, or is
created after the Issue Date of this Note, which default (a) is caused by a failure to pay principal of or premium, if any, or
interest on such Debt prior to the expiration of the grace period provided in such Debt on the date of such default or (b) results
in the acceleration of such Debt prior to its express maturity and, in each case in clause (a) or (b), the principal amount of
any such Debt, together with the principal amount of any other such Debt that has not been paid when due, or the maturity of which
has been so accelerated, aggregates $10,000,000 or more; or

 

(e) The Company’s
Board of Directors or stockholders adopt a resolution for the liquidation, dissolution or winding up of the Company.

 

Upon the occurrence of any Event of Default, all accrued but unpaid
expenses, accrued but unpaid interest, all principal and any other amounts outstanding under this Note shall (i) in the case of
any Event of Default under Section 5(b), become immediately due and payable in full without further notice or demand by Holder
and (ii) in the case of any Event of Default other than under Section 5(b), become immediately due and payable upon written notice
by or on behalf of all Holder(s) of then outstanding Notes. Notwithstanding any other provision of this Note, Holder agrees that
Holder will exercise Holder’s rights and remedies under this Note only in concert with all other holders of outstanding Notes
and will not take any action, including commencement or prosecution of litigation or any other proceeding to collect this Note,
except as agreed by the holders of a majority of the then outstanding principal amount of the Notes.

 

    	-7-

     

    

6. PROVISIONS RELATING TO STOCKHOLDER
RIGHTS. This Note does not entitle Holder to any voting rights or other rights as a stockholder of the Company. No provisions
of this Note and no enumeration herein of the rights or privileges of Holder, shall cause Holder to be a stockholder of the Company
for any purpose.

 

7. REPRESENTATIONS AND WARRANTIES
OF HOLDER. In order to induce the Company to issue this Note to the original Holder, the original Holder has made representations
and warranties to the Company as set forth in the Agreement.

 

8. GENERAL PROVISIONS.

 

8.1 Waivers. The Company and
all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

8.2 Transfer. Neither this Note
nor any rights hereunder may be assigned, conveyed or transferred, in whole or in part, without the Company’s prior written
consent, which the Company may withhold in its sole discretion; provided, however, that this Note may be assigned,
conveyed or transferred without the prior written consent of the Company to any Affiliate of Holder who (a) executes and delivers
an acknowledgement that such transferee agrees to be subject to, and bound by, all the terms and conditions of this Note, (b) makes
the representations and warranties to the Company that are set forth in Section 5 of the Agreement, and (c) (if requested by the
Company) delivers to the Company an opinion of legal counsel, reasonably satisfactory to the Company, that such transfer complies
with state and federal securities laws. Subject to the foregoing, the rights and obligations of the Company and Holder under this
Note shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators and transferees.

 

8.3 Governing Law. This Note
shall be governed, construed and interpreted in accordance with the laws of the State of California, without giving effect to principles
of conflicts of law.

 

8.4 Headings. The headings and
captions used in this Note are used only for convenience and are not to be considered in construing or interpreting this Note.
All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached
hereto, all of which exhibits are incorporated herein by this reference.

 

8.5 Notices. All notices, requests,
and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally
delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been
delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States
mail, registered or certified, return receipt requested, postage prepaid, in each case addressed, as to the Company, to Amyris,
Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number:

, with a copy to Fenwick & West LLP,
801 California Street, Mountain View, CA 94041, Attn: Dan Winnike, Esq., facsimile number:               , and as to Holder at the address
and facsimile number set forth opposite such Holder’s name on Schedule I to the Agreement or as otherwise
indicated by Holder by providing notice of a change in its address, facsimile number, or other information to the Company.
Holder and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic
communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to
particular notices or communications.

 

    	-8-

     

    

8.6 Place of Payment. Payments
of the Principal and any interest and other payments hereunder shall be delivered to the Holder at the address specified in the
Agreement or at such other address or the attention of such other Person as specified by prior written notice to the Company, including
any transferee of this Note.

 

8.7 Amendments and Waivers.
This Note and all other Notes issued under the Agreement may be amended and provisions may be waived by the Note holders holding
at least a majority of the then outstanding principal amount of Notes and the Company as provided in Section 10(j) of the Agreement.
Any amendment or waiver effected in accordance with Section 10(j) of the Agreement shall be binding upon each holder of any Notes
at the time outstanding, each future holder of the Notes and the Company.

 

8.8 Severability. If one or
more provisions of this Note are held to be unenforceable under applicable law, then such provision(s) shall be excluded from this
Note to the extent they are held to be unenforceable and the remainder of the Note shall be interpreted as if such provision(s)
were so excluded and shall be enforceable in accordance with its terms.

 

[Signature page follows]

 

    	-9-

     

    

IN WITNESS WHEREOF, the Company has caused this Secured Promissory
Note to be signed in its name as of the date first written above.

 

 

	 	 	THE COMPANY
	 	 	 
	 	 	AMYRIS, INC. 
	 	 	 
	 	 	By:  	/s/ Raffi Asadorian
	 	 	 	 
	 	 	Name: 	Raffi Asadorian
	 	 	 	 
	 	 	Title: 	Chief Financial Officer

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