Document:

Amended and Restated Agreement of Lease

Table of Contents

 Exhibit 10.1 
 AMENDED AND RESTATED AGREEMENT OF LEASE 
 between 

BMR-LANDMARK AT EASTVIEW LLC, 
 Landlord 
 and 

PROGENICS PHARMACEUTICALS, INC., 
 Tenant 
 Dated: October 28, 2009 

The Landmark at Eastview 
 Towns of Greenburgh 
 and Mount Pleasant 

Westchester County, New York 

Table of Contents

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
		
	 ARTICLE 1 GLOSSARY
	  	 	6	  
	 ARTICLE 2 DEMISE, PREMISES, TERM, RENT
	  	 	10	  
	 ARTICLE 3 TENANT’S TAX PAYMENT
	  	 	12	  
	 ARTICLE 4 TENANT’S OPERATING PAYMENT
	  	 	14	  
	 ARTICLE 5 USE AND OCCUPANCY
	  	 	19	  
	 ARTICLE 6 ALTERATIONS
	  	 	20	  
	 ARTICLE 7 REPAIRS; FLOOR LOAD
	  	 	23	  
	 ARTICLE 8 WINDOW CLEANING
	  	 	25	  
	 ARTICLE 9 REQUIREMENTS OF LAW
	  	 	25	  
	 ARTICLE 10 SUBORDINATION
	  	 	29	  
	 ARTICLE 11 RULES AND REGULATIONS
	  	 	32	  
	 ARTICLE 12 INSURANCE, PROPERTY LOSS OR DAMAGE; REIMBURSEMENT
	  	 	32	  
	 ARTICLE 13 DESTRUCTION BY FIRE OR OTHER CAUSE
	  	 	35	  
	 ARTICLE 14 EMINENT DOMAIN
	  	 	36	  
	 ARTICLE 15 ASSIGNMENT, SUBLETTING, MORTGAGE, ETC.
	  	 	37	  
	 ARTICLE 16 ACCESS TO PREMISES
	  	 	42	  
	 ARTICLE 17 CERTIFICATE OF OCCUPANCY
	  	 	44	  
	 ARTICLE 18 DEFAULT
	  	 	44	  
	 ARTICLE 19 REMEDIES AND DAMAGES
	  	 	46	  
	 ARTICLE 20 FEES AND EXPENSES
	  	 	48	  
	 ARTICLE 21 NO REPRESENTATIONS BY LANDLORD
	  	 	49	  
	 ARTICLE 22 END OF TERM
	  	 	50	  
	 ARTICLE 23 POSSESSION AND TENANT IMPROVEMENTS
	  	 	51	  
	 ARTICLE 24 NO WAIVER
	  	 	52	  
	 ARTICLE 25 WAIVER OF TRIAL BY JURY
	  	 	53	  
	 ARTICLE 26 INABILITY TO PERFORM
	  	 	54	  
	 ARTICLE 27 BILLS AND NOTICES
	  	 	54	  
	 ARTICLE 28 SERVICES AND EQUIPMENT
	  	 	55	  
	 ARTICLE 29 PARTNERSHIP TENANT
	  	 	59	  
	 ARTICLE 30 ELECTRIC ENERGY
	  	 	59	  
	 ARTICLE 31 SIGNS
	  	 	61	  
	 ARTICLE 32 BROKER
	  	 	61	  
	 ARTICLE 33 INDEMNITY
	  	 	62	  
	 ARTICLE 34 PARKING
	  	 	63	  
	 ARTICLE 35 SECURITY DEPOSIT
	  	 	63	  
	 ARTICLE 36 RENT REGULATION
	  	 	65	  
	 ARTICLE 37 [Intentionally omitted]
	  	 	66	  
	 ARTICLE 38 COVENANT OF QUIET ENJOYMENT
	  	 	66	  
	 ARTICLE 39 MISCELLANEOUS
	  	 	66	  
	 ARTICLE 40 [Intentionally omitted]
	  	 	70	  
	 ARTICLE 41 [Intentionally omitted]
	  	 	70	  
	 ARTICLE 42 [Intentionally omitted]
	  	 	70	  
	 ARTICLE 43 RENEWAL OPTIONS
	  	 	70	  
	 ARTICLE 44 TERMINATION OPTION
	  	 	72	  
	 ARTICLE 45 EXPANSION OPTION
	  	 	72	  
	 ARTICLE 46 RIGHT OF FIRST OFFER
	  	 	74	  

  
 (i)

Table of Contents

 AMENDED AND RESTATED AGREEMENT OF LEASE, made as of the 28th day of October, 2009 (the
“Execution Date”), between BMR-LANDMARK AT EASTVIEW LLC, a Delaware limited liability company (“Landlord”, as successor-in-interest to Eastview Holdings LLC (“Original Landlord”)), having an address
at 17190 Bernardo Center Drive, San Diego, California 92128, and PROGENICS PHARMACEUTICALS, INC., a Delaware corporation, having an address at 777 Old Saw Mill River Road, Tarrytown, New York 10591, as “Tenant”. 

REFERENCE PAGE 

In addition to other terms elsewhere defined in this Lease, the following terms whenever used in this Lease shall have the meanings set
forth in this Reference Page. 
  

			
	1) 769 Premises:	  	Collectively, (i) the Fourth Floor of the 769 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-l, containing approximately 24,875
square feet of rentable area, (ii) the portion of the Third Floor of the 769 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-l, containing approximately 15,525 square feet of rentable area, and (iii)
the portion of the First Floor of the 769 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-l, containing approximately 2,496 square feet of rentable area. For all purposes under this Lease, the 769
Premises is conclusively deemed to contain a total of 42,896 square feet of rentable area.
		
	2) 771 Premises:	  	Collectively, (i) the First Floor of the 771 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-2, containing approximately 52,420
square feet of rentable area, and (ii) the 771 Lower Level Premises. For all purposes under this Lease, the 771 Premises are conclusively deemed to contain 72,894 square feet of rentable area.
		
	3) 771 Lower Level Premises:	  	The lower level of the 771 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-2. For all purposes under this Lease, the 771 Lower
Level Premises are conclusively deemed to contain 20,474 square feet of rentable area.
		
	4) 777 Premises:	  	The portion of the Second Floor of the 777 Building, as approximately shown hatched on the floor plan annexed hereto as Schedule A-3. For

  
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		  	all purposes under this Lease, the 777 Premises are conclusively deemed to contain 33,526 square feet of rentable area.
		
	5) Premises:	  	Collectively, the 769 Premises, the 771 Premises, the 771 Lower Level Premises and the 777 Premises, as approximately shown hatched on the floor plan annexed hereto as
Schedule A. For all purposes under this Lease, the Premises are conclusively deemed to contain a total of 149,316 square feet of rentable area.
		
	6) 765 Building:	  	The building having a street address of 765 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule B.
		
	7) 769 Building:	  	The building having a street address of 769 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule B.
		
	8) 771 Building:	  	The building having a street address of 771 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule B.
		
	9) 777 Building:	  	The building having a street address of 777 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule B.
		
	l0) Building(s):	  	Collectively, the 769 Building, the 771 Building and the 777 Building, as identified on the plan annexed hereto as Schedule B (each, a “Building” and,
collectively, the “Buildings”). The Buildings are part of a larger development located along Old Saw Mill River Road, partly in the Town of Greenburgh and partly in the Town of Mount Pleasant, in the County of Westchester and State
of New York and called “The Landmark at Eastview.”
		
	11) Commencement Date:	  	 769 Premises: January 1, 2010

771 Premises: January 1, 2010
 777 Premises: The
date (the “777 Premises Commencement Date”) that is the later of (a) five months after the Execution Date, and (b) one

  
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		  	month after Substantial Completion of the Landlord Improvements and delivery of the 777 Premises to Tenant.
		
	12) Fixed Expiration Date:	  	December 31, 2020, subject to earlier termination or extension as provided herein.
		
	13) Fixed Rent:	  	Fixed Rent is set forth on Schedule I attached hereto and made a part hereof.
		
	14) Tenant’s Tax Proportionate Share:	  	Tenant’s Tax Proportionate Share shall be equal to the aggregate of the percentages listed below, but subject to change as provided in Sections 3.6 and 3.7.
Upon the respective Commencement Date for each of the spaces that comprise the Premises, the Tenant’s Tax Proportionate Share shall be increased to reflect the addition of such space to the Premises. Upon the earliest Commencement Date to
occur, initially Tenant’s Tax Proportionate Share shall be as follows:

  

									
	 	  	Core Campus	 	 	Existing
Campus	 
	 769 Premises:
	  	 	3.610	% 	 	 	5.182	% 
	 771 Premises:
	  	 	6.134	% 	 	 	8.806	% 
	 777 Premises:
	  	 	n/a	  	 	 	n/a	  
	 Entire Premises
	  	 	12.57	% 	 	 	18.04	% 

  

			
		  	For purposes of determining Tenant’s Tax Proportionate Share, Landlord and Tenant agree that as of the date of this Lease, the aggregate number of square feet of rentable
area of all buildings in the (i) Core Campus is conclusively deemed to be 1,188,310, and (ii) Existing Campus is conclusively deemed to be 827,790.
		
	15) Tenant’s Operating Proportionate Share:	  	Tenant’s Operating Proportionate Share shall be equal to the aggregate of the percentages listed below, but subject to change as provided in Sections 4.7 and 4.9.
Upon the respective Commencement Date for each of the spaces that comprise the Premises, Tenant’s Operating Proportionate Share shall be increased to reflect the addition of such space to the Premises. Upon

  
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		  	the earliest Commencement Date to occur, initially Tenant’s Tax Proportionate Share shall be as follows:

  

									
	 	  	Core Campus	 	 	Existing
Campus	 
	 769 Premises:
	  	 	3.610	% 	 	 	5.182	% 
	 771 Premises:
	  	 	6.134	% 	 	 	8.806	% 
	 777 Premises:
	  	 	n/a	  	 	 	n/a	  
	 Entire Premises
	  	 	12.57	% 	 	 	18.04	% 

  

			
		  	For purposes of determining Tenant’s Operating Proportionate Share, Landlord and Tenant agree that as of the date of this Lease, the aggregate number of square feet of
rentable area of all buildings in the (i) Core Campus is conclusively deemed to be 1,188,310, and (ii) Existing Campus is conclusively deemed to be 827,790.
		
	16) Security Deposit:	  	$200,000.
		
	17) Permitted Use:	  	Research and development of pharmaceutical products, manufacturing of clinical grade products (not to include commercial manufacturing), and general, executive and administrative
office use in connection therewith, use consistent with customary headquarter operations of a pharmaceutical company, plus uses incidentally and directly related to the foregoing and subject to all Requirements (as defined below).
		
	18) Broker.	  	CB Richard Ellis on behalf of Tenant.
		
	19) Number of Parking Spaces:	  	Tenant’s pro rata share (based on the entire Premises) of unreserved parking spaces and ten (10) reserved parking spaces, as show on Schedule H.
		
	20) Renewal Options:	  	Two (2) renewal options for five (5) years each.

  
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 RECITALS 
 A. WHEREAS, Original Landlord and Tenant entered into that certain Agreement of Lease dated as of September 23, 2003, as amended by that certain First Amendment of Lease dated as of May 17,
2004, that certain Second Amendment of Lease (Partial Termination Agreement) dated as of March 1, 2005, that certain Third Amendment to Agreement of Lease dated as of March 15, 2006, that certain Fourth Amendment to Agreement of Lease
dated as of August 9, 2007, that certain Fifth Amendment to Agreement of Lease dated as of November 30, 2007, and that certain Sixth Amendment to Agreement of Lease dated as of May 12, 2009 (collectively, and as the same may have been
further amended, supplemented or otherwise modified from time to time, the “Original Lease”), whereby Tenant leases certain premises as depicted on Schedule K hereto and located in the 765 Building (the “Old 765
Premises”) and the 777 Building (the “Old 777 Premises,” and collectively with the Old 765 Premises, the “Original Premises”) from Landlord; 

B. WHEREAS, Landlord has succeeded to Original Landlord’s interest in the Project; 

C. WHEREAS, Tenant occupies a portion of the 765 Building (the “Aton Subleased Premises”) pursuant to that certain
Sublease Agreement (as the same may have been amended, amended and restated or otherwise modified from time to time, the “Aton Sublease”) by and between Tenant (as subtenant) and Aton Pharma, Inc. (“Aton” as
sublandlord); 
 D. WHEREAS, effective as of the 777 Premises Commencement Date, Landlord and Tenant desire to terminate the
Aton Sublease; 
 E. WHEREAS, Landlord leased to Chemtura Corporation (“Chemtura,” formerly known as Crompton
Corporation, a Delaware corporation and successor-by-merger to Witco Corporation (formerly known as CK Witco Corporation)) the 769 Premises and the 771 Premises and Tenant occupies the 769 Premises and a portion of the 771 Premises (collectively,
the “Chemtura Subleased Premises”) pursuant to that certain Sublease Agreement dated as of January 27, 1998 (as the same has been amended, amended and restated or otherwise modified from time to time, the “Chemtura
Sublease”) by and between Chemtura (as sublandlord) and Tenant (as subtenant); 
 F. WHEREAS, Landlord and Chemtura
terminated the Chemtura lease (except for certain provisions that survived such termination) and consequently terminated the Chemtura Sublease, with Tenant agreeing to attorn to Landlord with respect to the Chemtura Subleased Premises; 

G. WHEREAS, Landlord desires to lease to Tenant and Tenant desires to lease from Landlord the Chemtura Subleased Premises as part of the
Premises; and 
 H. WHEREAS, Landlord and Tenant desire that (i) this Lease shall replace the Original Lease in its
entirety, (ii) as of the 777 Premises Commencement Date, Tenant surrender the Old 765 Premises and the Old 777 Premises and (iii) Tenant lease directly from Landlord the Premises on the terms and conditions set forth herein. 

  
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 W I T N E S E T H: 

The parties hereto, for themselves, their legal representatives, successors and assigns, hereby agree as follows: 

ARTICLE 1 
 GLOSSARY 
 The following terms shall have the meanings indicated below:

 “Additional Rent” shall have the meaning set forth in Section 2.2. 

“Alterations” shall mean alterations, decorations, installations, repairs, improvements, additions, replacements or
other physical changes in or about the Premises. 
 “Applicable Rate” shall mean the lesser of (x) four
percentage points above the then current Base Rate, and (y) the maximum rate permitted by applicable law. 

“Approved Examiner” shall have the meaning set forth in Section 4.5. 

“ASHRAE” shall mean the American Society of Heating, Refrigeration and Air-Conditioning Engineers. 

“Bankruptcy Code” shall mean 11 U.S.C. Section 101 et seq., or any statute, federal or state, of
similar nature and purpose. 
 “Base Rate” shall mean the rate of interest publicly announced from time to time
by Citibank, N.A., or its successor, as its “base rate” (or such other term as may be used by Citibank, N.A., from time to time, for the rate presently referred to as its “base rate”). 

“Building” (as a general term that is not initially capitalized and as a defined term that is initially capitalized)
shall include the building, equipment and other improvements and appurtenances of every kind and description now located or hereafter erected, constructed or placed upon the land beneath or immediately adjacent to any Building and any and all
alterations, renewals, and replacements thereof, additions thereto and substitutions therefor. 
 “Building
Systems” shall mean the base building mechanical, electrical, sanitary, heating, air conditioning, ventilating, elevator, plumbing, life-safety and other service systems of a Building, including the central plant which distributes electric
steam and chilled water to the Project, but shall not include installations made by Tenant or fixtures or appliances. 

“Business Days” shall mean all days, excluding Saturdays, Sundays and all days observed as holidays by the State of New
York, the federal government or the labor unions servicing the Buildings. 
 “Control” shall have the meaning
set forth in Section 15.2. 

  
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 “Core Campus” shall mean, as of the date of this Lease, the following
buildings located in the Project, which the parties agree conclusively contain the 1,188,310 square feet of rentable area consisting of the following (provided that, after the date of this Lease, the Core Campus is subject to change as
provided in Section 4.9): 
 735 Old Saw Mill River Road, comprised of 117,935 rentable square feet; 

745 Old Saw Mill River Road, comprised of 111,708 rentable square feet; 

755 Old Saw Mill River Road, comprised of 130,877 rentable square feet; 

765 Old Saw Mill River Road, comprised of 207,820 rentable square feet; 

767 Old Saw Mill River Road, comprised of 74,864 rentable square feet; 

769 Building, comprised of 106,422 rentable square feet; 
 771 Building, comprised of 72,894 rentable square feet; and 
 777 Building,
comprised of 365,790 rentable square feet. 
 “Deficiency” shall have the meaning set forth in
Section 19.2. 
 “Event of Default” shall have the meaning set forth in Section 18.1.

 “Existing Campus” shall mean 765 Old Saw Mill River Road, 767 Old Saw Mill River Road, 769 Building, 771
Building, and 777 Building, which the parties agree conclusively contain 827,790 square feet of rentable area (provided that, after the date of this Lease, the Existing Campus is subject to change as provided in Section 4.9).

 “Expiration Date” shall mean the Fixed Expiration Date or such earlier or later date on which the Term
sooner or later ends pursuant to any of the terms, conditions or covenants of this Lease or pursuant to law. 

“Government Authority (Authorities)” shall mean the United States of America, the State of New York, the County of
Westchester, any political subdivision thereof and any agency, department, commission, board, bureau or instrumentality of any of the foregoing, now existing or hereafter created, having jurisdiction over the Real Property or any portion thereof.

 “HVAC” shall mean heat, ventilation and air conditioning. 

“HVAC System” shall mean the Building Systems providing HVAC. 

“Hazardous Materials” shall have the meaning set forth in Section 9.2. 

“Improvements” shall mean the buildings and other improvements presently or hereafter located on the Land. 

“Indemnitees” shall mean Landlord, its trustees, partners, shareholders, officers, directors, employees, agents and
contractors and the Manager (and the partners, shareholders, officers, directors and employees of Landlord’s agents and contractors and of the Manager). 
 “Insurance Requirements” shall mean the rules, regulations, orders and requirements of the New York Board of Underwriters and/or the New York Fire Insurance Rating Organization and/or any
other similar body performing the same or similar functions and having jurisdiction or cognizance over the Buildings or the Premises, whether now or hereafter in force, and the requirements of any insurance policy maintained by Landlord. 

  
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 “Land” shall mean the land as of the date of this Lease on which The
Landmark at Eastview is located but thereafter, if title to any portion of the Land is transferred to an entity not controlled by, under common control with, or controlling, Landlord, then “Land” shall mean only that portion of the Land
not having been so transferred. 
 “Landlord” on the date as of which this Lease is made, shall mean
BMR-Landmark at Eastview LLC, a Delaware limited liability company, but thereafter, “Landlord” shall mean only the fee owner of the Real Property or, if there then exists a Superior Lease, the tenant thereunder. 

“Landlord Improvements” shall mean the work to be performed with respect to the Premises by Landlord in accordance with
Schedule J hereto. 
 “Landlord’s Operating Statement” shall mean a statement containing a
computation of Additional Rent due pursuant to the provisions of Article 4 furnished by Landlord to Tenant. 

“Landlord’s Statement” shall mean either a Landlord’s Operating Statement or a Landlord’s Tax Statement.

 “Landlord’s Tax Statement” shall mean a statement containing a computation of Additional Rent due
pursuant to the provisions of Article 3 furnished by Landlord to Tenant. 
 “Lease Year” or
“Lease Years” shall mean each twelve (12) month period beginning on the first day of the calendar month immediately following the month in which the Commencement Date occurs and each twelve (12) month period thereafter
beginning on the anniversary of the first day of the calendar month immediately following the month in which the Commencement Date occurs; provided, however, the first “Lease Year” shall include the number of days from the
Commencement Date through the last day of the calendar month in which the Commencement Date occurs. 

“Lessor(s)” shall mean a lessor under a Superior Lease. 

“Manager” shall mean Landlord, or any successor contractor under Landlord’s contract for the management of the
Buildings. 
 “Mortgage(s)” shall mean any trust indenture or mortgage which may now or hereafter affect the
Real Property, the Buildings or any Superior Lease and the leasehold interest created thereby, and all renewals, extensions, supplements, amendments, modifications, consolidations and replacements thereof or thereto, substitutions therefor, and
advances made thereunder. 
 “Mortgagee(s)” shall mean any trustee under or mortgagee or holder of a Mortgage.

 “Notice(s)” shall have the meaning set forth in Section 27.1. 

“Operating Expenses” shall have the meaning set forth in Article 4. 

  
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 “Operating Hours” shall mean twenty-four (24) hours per day, seven
(7) days per week, three hundred sixty-five (365) days per year. 
 “Operating Year” shall mean each
calendar year that includes any part of the Term. 
 “Parties” shall have the meaning set forth in
Section 39.2. 
 “Partnership Tenant” shall have the meaning set forth in Article 29.

 “Person(s) or person(s)” shall mean any natural person or persons, a partnership, a corporation and any
other form of business or legal association or entity. 
 “Persons Within Tenant’s Control” shall mean and
include Tenant, all of Tenant’s respective principals, officers, agents, contractors, servants, employees, licensees and invitees. 
 “Project” or “Real Property” (which are used interchangeably) shall mean the Land, the Buildings and all other buildings and other improvements presently and hereafter
located on the Land. 
 “Rental” shall mean and be deemed to include Fixed Rent, Additional Rent and any other
sums payable by Tenant hereunder. 
 “Requirements” shall mean (i) all present and future laws, rules,
ordinances, regulations, statutes, requirements, codes and executive orders, extraordinary as well as ordinary, retroactive and prospective, of all Government Authorities now existing or hereafter created, and of any applicable fire rating bureau,
or other body exercising similar functions, affecting the Real Property, or any street, avenue or sidewalk comprising a part or in front thereof or any vault in or under the same, or requiring removal of any encroachment, or affecting the
maintenance, use or occupation of the Real Property, (ii) all requirements, obligations and conditions of all instruments of record on the date of this Lease, and (iii) all Insurance Requirements. 

“Rules and Regulations” shall mean the rules and regulations annexed hereto as Schedule C, and such other and
further reasonable non-discriminatory rules and regulations and standards as Landlord and Landlord’s agents may from time to time adopt, on notice to Tenant to be given as Landlord may elect. 

“Substantial Completion” or “Substantially Complete” shall mean, with respect to the Landlord
Improvements, that such improvements are complete in accordance with the description of the Landlord Improvements set forth on Schedule J annexed hereto, except for seasonal and minor punch list items that do not materially and adversely
affect Tenant’s use of the Premises Permitted Use. 
 “Superior Lease(s)” shall mean all ground or
underlying leases of the Real Property or the Buildings heretofore or hereafter made by Landlord and all renewals, extensions, supplements and modifications thereof. 
 “Taxes” shall have the meaning set forth in Section 3.1. 
 “Tax Year” shall have the meaning set forth in Section 3.1. 

  
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 “Tenant”, on the date as of which this Lease is made, shall mean the Tenant
named in this Lease, but thereafter “Tenant” shall mean only the tenant under this Lease at the time in question; provided, however, that the Tenant named in this Lease and any successor tenant hereunder shall not, except as
otherwise provided herein or otherwise agreed to in writing by Landlord, be released from liability hereunder in the event of any assignment of this Lease. 
 “Tenant’s Operating Payment” shall have the meaning set forth in Section 4.2. 
 “Tenant’s Property” shall mean Tenant’s trade fixtures, movable fixtures and movable partitions, telephone and other equipment, furniture, furnishings and other movable items of
personal property. 
 “Tenant’s Tax Payment” shall have the meaning set forth in Section 3.3.

 “Term” shall mean the period from the earliest Commencement Date through and including the Fixed Expiration
Date, subject to earlier termination or extension as provided herein. 
 “Unavoidable Delays” shall have the
meaning set forth in Article 26. 
 ARTICLE 2 

DEMISE, PREMISES, TERM, RENT 
 Section 2.1 Landlord hereby leases to Tenant and Tenant hereby hires from Landlord the Premises for the Term to commence, subject to Article 23, on the applicable Commencement Date set forth
in Paragraph 11 of the Reference Page and to expire on the Expiration Date (with respect to the entire Premises). Effective as of the Execution Date, this Amended and Restated Agreement of Lease (this “Lease”) amends and restates
the Original Lease in its entirety; provided that (i) the Parties’ obligations that, pursuant to the terms thereof expressly survive the expiration or earlier termination thereof, shall, with respect to the period until the date
hereof, continue to survive, and (ii) with respect to the Original Premises, the Original Lease shall remain in effect through and including December 31, 2009. 
 Section 2.2 Commencing upon the applicable Commencement Date, Tenant shall pay to Landlord, in lawful money of the United States of America, without notice or demand, either by (i) good and
sufficient check drawn to Landlord’s order and delivered to Unit A, P.O. Box 51918, Los Angeles, CA 90051-6218, or (ii) wire transfer to the following account: 
 Name of beneficiary: BMR-Landmark at Eastview LLC 
 Account number: 153454489623

 Bank Name: US Bank. Routing/Transit #: 122235821 
 Branch Name & Address: San Diego Main, 600 W. Broadway #100, San Diego, CA 92101, 

  
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 or at such other place, or to Landlord’s agent and at such other place, as Landlord may designate from
time to time, the following: 
 (A) the Fixed Rent, at the annual fixed rental rate set forth in Schedule 1, which shall
be payable in equal monthly installments of Fixed Rent in advance on the first day of each and every calendar month during the Term; and 
 (B) additional rent (“Additional Rent”) consisting of all other sums of money (including, without limitation, any Tenant’s Operating Payment and any Tenant’s Tax Payment) as
shall become due from and be payable by Tenant hereunder (for default in the payment of which Landlord shall have the same remedies as for a default in the payment of Fixed Rent). 

Section 2.3 If the Commencement Date is other than the first day of a calendar month, or if the last day of the Term is other than
the last day of a calendar month, Fixed Rent for such month shall be prorated on a per diem basis. 
 Section 2.4 Tenant
shall have the right to enter into any portion of the 771 Premises not currently occupied by Tenant prior to the Commencement Date for such Premises for the sole purpose of performing any Landlord-approved Tenant improvements, such as installing
data and communication equipment, trade fixtures or furniture. 
 Section 2.5 Tenant shall pay the Fixed Rent and
Additional Rent when due without abatement, deduction, counterclaim, set-off or defense for any reason whatsoever, except said abatement as may be occasioned by the occurrence of any event permitting an abatement of Fixed Rent and Tenant’s Tax
Payment and Tenant’s Operating Payment, as specifically set forth in this Lease. 
 Section 2.6 Tenant shall have the
right to continue to occupy the Old 765 Premises, the Old 777 Premises (pursuant to the terms of this Amended and Restated Agreement of Lease) and the Aton Subleased Premises (pursuant to the Aton Sublease if the Aton Sublease is still in effect),
provided that Tenant shall continue to pay (a) Rental for the Old 765 Premises and the Old 777 Premises in the amounts set forth in the Original Lease and (b) Rental for the Aton Subleased Premises in the amounts set forth in the Aton
Sublease (if the Aton Sublease is still in effect), as applicable until the 777 Premises Commencement Date, at which time, Tenant shall surrender the Old 765 Premises and the Old 777 Premises, and the Aton Subleased Premises if then occupied by
Tenant, in the condition required under Article 22 and commence paying Rental on the 777 Premises at the rate set forth herein. If the Aton Sublease and Landlord’s lease with Aton have expired prior to the 777 Premises Commencement Date,
then Tenant shall have the right to occupy the Aton Subleased Premises as part of the Premises under this Lease at the Rental rate set forth in the Original Lease. If the 777 Premises Commencement Date has not occurred by September 1, 2010,
Tenant may at any time thereafter, upon notice to Landlord, surrender to Landlord any portions of the Old 765 Premises and/or Old 777 Premises which are capable of being separately leased from the balance of the Old 765 Premises and/or Old 777
Premises, such surrender to be effective on the date specified in such notice from Tenant, provided the effective date shall not be earlier than thirty (30) days from the date of such notice. Landlord shall be responsible, at Landlord’s
sole cost and expense, as soon as practicable after Tenant’s notice of such surrender, for separating any space so surrendered (including the installation of demising walls, doors and locks) from the balance of the Old 765 Premises and Old 777
Premises in compliance with all applicable Requirements. Tenant shall surrender all of the Old 777 Premises to Landlord before surrendering any portion of the Old 765 Premises. 

  
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 Section 2.7 Notwithstanding the foregoing, Landlord represents and warrants to Tenant
that there is vacant space in the Core Campus that will allow Landlord to provide relocation space to any third-party occupants of any portion of the 777 Premises. Landlord hereby agrees to use all commercially reasonable efforts to promptly
relocate such third-party occupants in order to obtain vacant possession of the 777 Premises, free and clear of all tenancies and/or rights of occupancy by parties other than Tenant. Landlord further represents and warrants to Tenant that there is
presently only one (1) occupant of the 777 Premises as to which Landlord does not have the right to move such tenant out of the 777 Premises. With respect to such tenant, Landlord shall provide Tenant with a copy of a written agreement (from
which any monetary terms may be redacted) to terminate occupancy in the 777 Premises promptly after signing by such tenant. 
 
ARTICLE 3 
 TENANT’S TAX PAYMENT 
 Section 3.1 For the purposes of this Article 3 and other provisions of this Lease: 
 (A) The term “Taxes” shall mean (i) the real estate taxes, assessments and special assessments imposed upon the Project (whether or not comprised of one (1) or more tax lots
(but Taxes shall not include, and Tenant shall not be responsible for, any taxes related to any undeveloped Land that is an independent tax lot) by any federal, state, municipal or other governments or governmental bodies or authorities, and
(ii) any expenses incurred by Landlord in contesting such taxes or assessments and/or the assessed value of the Improvements and/or the Land, which expenses shall be allocated to the Tax Year to which such expenses relate. If at any time during
the Term the methods of taxation prevailing on the date hereof shall be altered so that in lieu of, or as an addition to or as a substitute for, the whole or any part of such real estate taxes, assessments and special assessments now imposed on real
estate there shall be levied, assessed or imposed (x) a tax, assessment, levy, imposition, license fee or charge wholly or partially as a capital levy or otherwise on the rents received therefrom, or (y) any other such additional or
substitute tax, assessment, levy, imposition or charge, then all such taxes, assessments, levies, impositions, fees or charges or the part thereof so measured or based shall be deemed to be included within the term “Taxes” for the purposes
hereof. 
 (B) The term “Tax Year” shall mean the period of twelve (12) calendar months beginning on
January 1 of the year in which the Term commences, and each succeeding twelve (12)-month period thereafter. 

Section 3.2 Any Taxes for a real estate fiscal tax year, a part of which is included within a particular Tax Year and a part of
which is not so included, shall be apportioned on the basis of the number of days in the real estate fiscal tax year included in the particular Tax Year for the purpose of making the computations under Section 3.3. 

Section 3.3 For each Tax Year, any part of which shall occur during the Term, Tenant shall pay to Landlord an amount (prorated to
the extent provided in Section 3.10, if applicable) (herein called “Tenant’s Tax Payment”) equal to Tenant’s Tax Proportionate Share of the Taxes for such Tax Year. Tenant’s Tax Payment shall be paid by
Tenant to Landlord in twelve (12) 

  
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equal monthly installments (subject to the further provisions of this Section 3.3), the first of which shall be due within ten (10) days after receipt of a Landlord’s Tax
Statement, regardless of whether such Landlord’s Tax Statement is received prior to, on or after the first day of such Tax Year and the remaining installments shall be due on the first day of each month thereafter. Landlord shall bill (herein
called “Landlord’s Tax Statement”) Tenant for any Tenant’s Tax Payment installment(s) payable by Tenant pursuant to this Article, such bill to set forth in reasonable detail the computation of the Tax Payment and the
particular installment(s) thereof being billed. In the event of any increase in the Taxes for any Tax Year, whether during or after such Tax Year, or any decrease in the Taxes during such Tax Year, the Tax Payment for such Tax Year shall be
appropriately adjusted and paid or refunded, as the case may be, in accordance therewith. If, during the Term, Taxes are required to be paid (either to the appropriate taxing authorities or as tax escrow payments to the Lessor or the Mortgagee), in
full or in quarterly or other installments on any other date or dates than as presently required, then Tenant’s Tax Payments shall be correspondingly accelerated or revised so that installments of Tenant’s Tax Payment are due at least
thirty (30) days prior to the date payments are due to the taxing authorities, the Lessor or the Mortgagee. 

Section 3.4 Only Landlord shall be eligible to institute tax reduction or other proceedings to reduce Taxes. If Landlord shall
receive a refund of the Taxes for any Tax Year, Landlord shall either pay to Tenant, or permit Tenant to credit against subsequent payments under this Lease, (a) Tenant’s Tax Proportionate Share of the net refund (after deducting from such
total refund the costs and expenses, including, but not limited to, appraisal, accounting and legal fees of obtaining the same, to the extent that such costs and expenses were not included in the Taxes for such Tax Year), or (b) the amount of
any Tax rebate directly attributable to the Tenant Improvements capitalized by Tenant exclusive of the TI Allowance and separately itemized on such tax invoice; provided, however, such payment or credit to Tenant shall in no event exceed
Tenant’s Tax Payment paid for such Tax Year. Any refund of Taxes payable to Tenant under this Section shall include interest, but only if and to the extent Landlord receives interest on such Tax refund from the taxing authority. 

Section 3.5 Omitted. 
 Section 3.6 At any time and from time to time Landlord may, in its sole discretion, calculate Taxes based on the separate tax lot upon which a Building is then located or such multiple tax lots
designed by Landlord in its sole discretion, provided a Building is then located on one or more of such multiple tax lots, and in which case the term “Tenant’s Tax Proportionate Share” shall mean the percentage that represents
a fraction, the numerator of which is the number of square feet of rentable area in the Premises (excluding the 777 Premises), and the denominator of which is the aggregate number of square feet of rentable area of all buildings then on such tax lot
or lots included in such calculation. Landlord intends to and shall have the right at any time to cause part or parts of the Land to become a separate tax lot or separate tax lots in connection with future development thereof, in which event,
commencing on the date on which Taxes on such separate tax lot or lots are paid by a third party, Taxes shall no longer include the real estate taxes, assessments and special assessments imposed on such separate tax lot or lots. 

Section 3.7 If any building is enlarged, demolished or removed from the Land or any new building is erected on the Land, the term
“Tenant’s Tax Proportionate Share” shall mean the percentage that represents a fraction, the numerator of which is the number of square feet of rentable area in the Premises (excluding the 777 Premises), and the denominator of
which is the aggregate number of square feet of rentable area of all buildings then on the Land. 

  
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 Section 3.8 Tenant shall pay to Landlord upon demand as Additional Rent any occupancy
tax or rent tax now in effect or hereafter enacted, if payable by Landlord in the first instance or hereafter required to be paid by Landlord. 
 Section 3.9 Landlord’s failure to render any Landlord’s Statement with respect to any Tax Year shall not prejudice Landlord’s right thereafter to render a Landlord’s Statement
with respect thereto or with respect to any subsequent Tax Year, nor shall the rendering of a Landlord’s Statement prejudice Landlord’s right thereafter to render a corrected Landlord’s Statement for that Tax Year. Nothing herein
contained shall restrict Landlord from issuing a Landlord’s Statement at any time there is an increase in Taxes during any Tax Year or any time thereafter. The rights and obligations of Landlord and Tenant under the provisions of this
Article 3 with respect to any Tenant’s Tax Payment shall survive the Expiration Date. 
 Section 3.10 If the
Commencement Date shall occur other than on the first day of a Tax Year or a Tax Year ends after the expiration or termination of this Lease, any Additional Rent in respect thereof payable under this Article shall be equitably prorated to correspond
to that portion of the Tax Year occurring within the Term. 
 Section 3.11 The parties acknowledge that the rentable area
of the 777 Premises shall not be included in the calculation of Tenant’s Tax Proportionate Share. 
 ARTICLE 4 

TENANT’S OPERATING PAYMENT 
 Section 4.1 For the purposes of this Article 4 and other provisions of this Lease: 
 (A) The term “Operating Expenses” shall mean all expenses paid or incurred by Landlord or on Landlord’s behalf in respect of the repair, maintenance and operation of the Core Campus,
the Existing Campus and buildings comprising other Cost Pools as determined by the Landlord (and subject to Section 4.9 below), including, without limitation, all expenses paid or incurred as a result of Landlord complying with its
obligations under this Lease. Operating Expenses shall include, without limitation, (i) salaries, wages, medical, surgical, union and general welfare benefits (including, without limitation, group life insurance and pension and welfare payments
and contributions and all other fringe benefits paid to, for or with respect to all persons (whether employees of Landlord or its managing agent) engaged in the repair, operation and maintenance of the Core Campus (excluding employees to the extent
their time is not spent on the operation of the Core Campus); (ii) payroll taxes, workers’ compensation, uniforms, dry cleaning, and related expenses for such persons; (iii) the cost of all charges for gas, steam, electricity, heat,
ventilation, air-conditioning, water and other utilities furnished to the buildings within the Core Campus (including, without limitation, the common areas thereof) together with any taxes on such utilities (excluding however, the cost of
electricity, heat, ventilating and air-conditioning described in clauses (9) and (10) of this definition); (iv) the cost of painting the common areas of the Project; (v) charges for telephone service for the management of the Core

  
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Campus; (vi) financial expenses incurred in connection with the operation of the Core Campus, such as insurance premiums (including, without limitation, liability insurance, fire and
casualty insurance, rent insurance and any other insurance), reasonable attorneys’ fees and disbursements (exclusive of any such fees and disbursements incurred in applying for any reduction of Taxes or in connection with the leasing of space
in the Core Campus or the enforcement of leases or in any way related to obtaining financing for the Project), auditing, accounting and other professional fees and expenses, association dues and any other ordinary and customary financial expenses
incurred in connection with the operation of the Core Campus; (vii) the cost of purchases and rentals of all supplies (including, without limitation, building and cleaning supplies), tools (including, without limitation, hand tools), materials
and equipment (both movable and immovable), and replacements for tools and equipment used in the operation, maintenance, and repair of the Core Campus and sales and other taxes thereon; (viii) charges of independent contractors (including,
without limitation, for window and other cleaning and janitorial and security services); (ix) the cost of repairs and replacements made by Landlord; (x) the cost of alterations and improvements to the Core Campus made by reason of
Requirements not in effect on the date hereof; (xi) payments under service contracts (including, without limitation, for window and other cleaning and janitorial and security services); (xii) management fees but not to exceed four percent
(4%) of the aggregate rents, additional rents, and other charges payable to Landlord by tenants of the Core Campus; provided that if Landlord or an affiliate of Landlord is the managing agent, then a sum equal to four percent (4%) of the
aggregate rents, additional rents and other charges payable to Landlord by tenants in the Core Campus; (xiii) the reasonable costs of operating an on-site management office, including, without limitation, the fair market rental value thereof;
and (xiv) all other charges properly allocable to the repair, operation and maintenance of the Core Campus in accordance with generally accepted accounting principles; excluding, however, (1) depreciation, (2) interest on and
amortization of debts, (3) ground rent, (4) leasehold improvements made for existing or future tenants of the Core Campus, (5) brokerage commissions, (6) refinancing costs, (7) costs and expenses in connection with the
expansion of buildings or the construction of new buildings, (8) Taxes, and (9) the cost of Basic Electric and HVAC Electric (as such terms are defined in Section 30.1) furnished to the Premises or to other tenants of the Core
Campus and (10) the cost of producing and furnishing steam and chilled water to provide heat, ventilating and air-conditioning furnished to the Premises or to other tenants of the Core Campus (11) costs paid or reimbursed directly by
Tenant or another tenant in the Project (as distinguished from costs that are passed along to other tenants by virtue of provisions in their leases, analogous to this Article 4, which require them to pay a proportionate share of operating
costs or increases therein), (12) capital improvements that do not qualify under clause (x) above and are not either (a) of a type which will reduce Operating Expenses or (b) reasonably required to maintain the condition of the
Project in substantially the condition that it is as of the date hereof. If the capital expenditure is of a type which will reduce Operating Expenses, and does not qualify under the foregoing clause 12(b), then the amount of such expenditure will
not exceed the amount of Operating Expense savings achieved, and (13) costs and expenses incurred in connection with the demolition and removal of any buildings on the Land. The cost of any capital improvement (excluding any new buildings or
expansions of buildings) or machinery or equipment shall be included in Operating Expenses for the Operating Year in which such improvement was made or machinery or equipment was purchased, provided that to the extent the cost of such capital
improvement or machinery or equipment is required to be capitalized for federal income tax purposes, such cost shall be amortized on a straight-line basis over the useful life thereof utilized 

  
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 for federal income tax purposes, and the annual amortization of such capital improvement or machinery or
equipment, together with interest on the unamortized balance of such cost at the Applicable Rate, shall be included in Operating Expenses. Any cost or expense shall be included in Operating Expenses for any Operating Year no more than once,
notwithstanding that such cost or expense may fall under more than one of the categories listed above. Landlord may use related or affiliated entities to provide services or furnish materials for the Core Campus provided that the rates or fees
charged by such entities are competitive with those charged by unrelated or unaffiliated entities for the same services or materials, unless a fee or rate is specified in this Lease, in which event such fee or rate shall prevail. If during any
Operating Year the tenant or occupant of any space in the Core Campus undertook to perform work or services therein in lieu of having Landlord perform the same and the cost thereof would have been included in Operating Expenses if done by Landlord,
then, in any such event(s), the Operating Expenses for such Operating Year shall include the amount that would have been incurred if Landlord had performed such work or services, as the case may be, to the extent necessary only to allow Landlord to
collect in full Landlord’s actual cost for performing such work or service for the remaining tenants of the Project. If less than all of the rentable area of the Core Campus is occupied by tenants at any time during any Operating Year, the
Operating Expenses for such Operating Year shall be deemed to be the amount that Operating Expenses would have been had all of such rentable area been one hundred percent (100%) occupied throughout such Operating Year. The provisions of the prior
sentence with respect to adjustments of Operating Expenses for vacancy, shall apply only to Operating Expenses which are variable and which increase in the same relationship to the increase in occupancy in the Buildings and shall not apply to any
Operating Expenses which do not vary with the level of occupancy in the Buildings. Operating Expenses shall be calculated on the accrual basis of accounting. With respect to any expenses paid or incurred by Landlord for the repair, maintenance and
operation of the Core Campus and other buildings on the Land not comprising the Core Campus, Landlord shall equitably allocate, using good accounting principles, said expenses between the Core Campus and such other buildings. Notwithstanding the
foregoing, Operating Expenses shall not include (i) expenditures for which Landlord is reimbursed from any insurance carrier, Tenant (except pursuant to Tenant’s obligation to pay its Proportionate Share of Operating Expenses) or other source
or (ii) franchise taxes and income taxes. 
 (B) The term “Landlord’s Operating Statement” shall mean a
written statement prepared by Landlord or its agent, setting forth Landlord’s computation of the sum payable by Tenant under this Article for a specified Operating Year. 
 Section 4.2 For each Operating Year, any part of which occurs during the Term, Tenant shall pay to Landlord an amount (prorated to the extent provided in Section 4.6, if applicable) (herein called
“Tenant’s Operating Payment”) equal to Tenant’s Operating Proportionate Share of the Operating Expenses for such Operating Year. Said payments shall be made as provided in Section 4.3. 

Section 4.3 Landlord may furnish to Tenant, prior to the commencement of each Operating Year (or, in the case of the Operating Year in
which the Term commences, prior to the Commencement Date), a written statement setting forth Landlord’s estimate of the Operating Payment for such Operating Year. Tenant shall pay to Landlord on the first day of each month during such Operating
Year (or the portion thereof subsequent to the Commencement Date, as the case may be) an amount equal to one-twelfth of Landlord’s estimate of the Operating 

  
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Payment for such Operating Year. If, however, Landlord shall furnish any such estimate for an Operating Year subsequent to the commencement thereof, then (a) until the first day of the month
following the month in which such estimate is furnished to Tenant, Tenant shall pay to Landlord on the first day of each month an amount equal to the monthly sum payable by Tenant to Landlord under this Section in respect of the last month of the
preceding Operating Year; (b) after such estimate is furnished to Tenant or included in or together with such estimate, Landlord shall give notice to Tenant stating whether the installments of the Operating Payment previously made for such Operating
Year were greater or less than the installments of the Operating Payment to be made for such Operating Year in accordance with such estimate, and (i) if there shall be a deficiency, Tenant shall pay to Landlord the amount thereof within ten (10)
days after demand therefor, or (ii) if there shall have been an overpayment, Landlord shall promptly either refund to Tenant the amount thereof or permit Tenant to credit the amount thereof against subsequent payments under this Article or
Article 4; and (c) on the first day of the month following the month in which such estimate is furnished to Tenant, and monthly thereafter throughout the remainder of such Operating Year, Tenant shall pay to Landlord an amount equal to
one-twelfth of the Operating Payment shown on such estimate. Landlord may, at any time or from time to time during each Operating Year, furnish to Tenant a revised statement of Landlord’s estimate of the Operating Payment for such Operating
Year; and in such case, the Operating Payment for such Operating Year shall be adjusted and paid or refunded, as the case may be, substantially in the same manner as provided in the preceding sentence. 

Section 4.4 Within one hundred twenty (120) days after the end of each Operating Year Landlord shall furnish to Tenant Landlord’s
Operating Statement for such Operating Year. If Landlord’s Operating Statement shows that the sums paid by Tenant under Section 4.3 exceeded the Operating Payment to be paid by Tenant for such Operating Year, Landlord shall promptly
either refund to Tenant the amount of such excess or permit Tenant to credit the amount of such excess against subsequent payments under this Article or Article 3; and if Landlord’s Operating Statement for such Operating Year shows that
the sums so paid by Tenant were less than the Operating Payment to be paid by Tenant for such Operating Year, Tenant shall pay to Landlord the amount of such deficiency within ten (10) day’s after demand therefor. 

Section 4.5 Tenant, upon notice given within ninety (90) days after any Landlord’s Operating Statement is sent to Tenant, may elect
to have an Approved Examiner examine such of Landlord’s books and records as are directly relevant to the Landlord’s Operating Statement in question. Such Approved Examiner shall complete its examination of such books and records within a
reasonable period of time after Tenant’s notice of examination is given to Landlord (but in no event longer than ninety (90) days). An “Approved Examiner” shall mean an independent certified public accountant or accountants
(who may be an employee of Tenant) which is not being compensated by Tenant, in whole or in part, on a contingency basis provided that such Approved Examiner is not and has not during the Term been affiliated with, a shareholder in, an officer,
director, partner, or employee of, any Manager during the Term or the Manager named in this Lease. Tenant recognizes the confidential nature of Landlord’s books and records and agrees that information obtained by it or an Approved Examiner
during any examination (including any compromise, settlement or adjustment relating to the results of such examination) shall be maintained in strict confidence by Tenant and such Approved Examiner. As a condition precedent to Tenant’s exercise
of its right to examine Landlord’s books and records, Tenant shall deliver to Landlord a confidentiality agreement, reasonably satisfactory to Landlord, from the Approved Examiner to the same effect as Tenant’s agreement contained in the
preceding 

  
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sentence. If, after such examination, such Approved Examiner shall dispute such Landlord’s Operating Statement, either party may refer the decision of the issues raised to a reputable
independent firm of certified public accountants which has not performed services valued at Twenty-Five Thousand Dollars ($25,000) or more for either party hereunder in the most recent three year period, selected by Landlord and approved by Tenant,
which approval shall not be unreasonably withheld or delayed, and the decision of such accountants shall be conclusively binding upon the parties. The fees and expenses involved in resolving such dispute shall be borne by the unsuccessful party (and
if both parties are partially unsuccessful, the accountants shall apportion the fees and expenses between the parties based upon the degree of success of each party). If Tenant shall not give such notice within such ninety (90)-day period, then the
Operating Statement as furnished by Landlord shall be conclusive and binding upon Tenant. Tenant, pending the resolution of any contest shall continue to pay all sums as determined to be due in the first instance by Landlord’s Operating
Statement and upon the resolution of such contest, suitable adjustment shall be made in accordance therewith with appropriate refund to be made by Landlord to Tenant (or credit allowed Tenant against the Fixed Rent and Additional Rent becoming due).
If it is determined that Landlord, during an Operating Year, overcharged Tenant for Operating Expenses by an amount that exceeds four percent (4%) of Tenant’s total Operating Payment for such Operating Year, Landlord shall reimburse Tenant for
the reasonable cost incurred by Tenant in performing the audit of Landlord’s books and records. 
 Section 4.6 If the
Commencement Date shall occur other than on the first day of an Operating Year or an Operating Year ends after the expiration or termination of this Lease, any Additional Rent in respect thereof payable under this Article shall be equitably prorated
to correspond to that portion of the Operating Year occurring within the Term. 
 Section 4.7 If any building comprising the
Core Campus is enlarged, demolished or removed from the Core Campus, or any building or the Land is added to the Core Campus (which Landlord may do in its sole and absolute discretion), the term “Tenant’s Operating Proportionate
Share” shall be adjusted to mean the percentage that represents a fraction the numerator of which is the number of square feet of rentable area in the Premises (excluding the 777 Premises) and the denominator of which is the aggregate
number of square feet of rentable area of all buildings then comprising the Core Campus. 
 Section 4.8 Landlord’s failure
to render any Landlord’s Statement with respect to any Operating Year shall not prejudice Landlord’s right thereafter to render a Landlord’s Statement with respect thereto or with respect to any subsequent Operating Year, nor shall
the rendering of a Landlord’s Statement prejudice Landlord’s right thereafter to render a corrected Landlord’s Statement for that Operating Year. Nothing herein contained shall restrict Landlord from issuing a Landlord’s
Statement at any time there is an increase in Operating Expenses during any Operating Year or any time thereafter. All rights and obligations of Landlord and Tenant under the provisions of this Article 4 shall survive the Expiration Date.

 Section 4.9 Landlord shall have the right, from time to time, upon prior notice to Tenant, to equitably allocate some or all
of the Operating Expenses between the Buildings and/or different buildings of the Core Campus and/or among different tenants, regardless of use, of the Core Campus (the “Cost Pools”). Landlord shall have the right to add, enlarge,
demolish or remove any portion of the Core Campus or Existing Campus, any building, or the Land (which Landlord may do in its sole and absolute discretion). Tenant’s Operating Proportionate Share for 

  
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the applicable Cost Pool shall initially be a fraction, the numerator of which is the number of square feet of rentable area in the Premises (excluding the 777 Premises) and the
denominator of which is the aggregate number of square feet of rentable area of all buildings then comprising the applicable Cost Pool; provided, however, that Landlord shall have the right to proportionally adjust Tenant’s Operating
Proportionate Share based on Tenant’s usage, as reasonably determined by Landlord. 
 Section 4.10 The parties acknowledge
that the rentable area of the 777 Premises shall not be included in the calculation of Tenant’s Operating Proportional Share; however, Tenant shall pay, as part of Tenant’s Operating Payment, the cost of all electrical power (including,
without limitation, Basic Electric and to the extent HVAC equipment serves the 777 Premises, HVAC Electric) provided to the Premises (the “777 Electrical Payment”). Landlord shall install a submeter for the 777 Premises at
Landlord’s sole cost and expense. Landlord shall have the right, but not the obligation to purchase, install and monitor submetering equipment for the Premises and remainder of the Core Campus, the cost of which shall be an Operating Expense
(except for any electrical submeter installed for the 777 Premises, which shall be at Landlord’s sole cost and expense). 

ARTICLE 5 

USE AND OCCUPANCY 
 Section 5.1 Tenant shall use and occupy the Premises for the Permitted Use and for no other purpose. Landlord acknowledges and agrees that Tenant’s use of the Premises will include the use of one (I)
or more bio-reactors to the extent permitted by the Requirements. 
 Section 5.2 Tenant shall not use the Premises or any part
thereof, or permit the Premises or any part thereof to be used, (1) for the business of photographic, multilith or multigraph reproductions or offset printing (other than those which are ancillary to an otherwise Permitted Use), (2) for an
off-the-street retail commercial banking, thrift institution, loan company, trust company, depository or safe deposit business accepting deposits from the general public, (3) for the off-the-street retail sale of travelers checks, money orders,
drafts, foreign exchange or letters of credit or for the receipt of money for transmission, (4) by the United States government, the City or State of New York, any foreign government, the United Nations or any agency or department of any of the
foregoing having or asserting sovereign immunity, (5) for the preparation, dispensing or consumption of food or beverages in any manner whatsoever, except for the preparation, dispensing and consumption of food by Tenant’s employees who work in
the Premises and not for the sale of food to any Persons other than such employees, (6) as an employment agency, day-care facility, labor union, school, or vocational training center (except for the training of employees of Tenant intended to be
employed at the Premises), (7) as a barber shop, beauty salon or manicure shop, (8) omitted, (9) as offices of any public utility company, (10) for data processing activities (other than those which are ancillary to an otherwise Permitted Use), (11)
medical offices or a medical clinic, (12) for clerical support services or offices of public stenographers or typists (other than those which are ancillary to an otherwise Permitted Use), (13) as reservation centers for airlines or travel agencies,
(14) for retail or manufacturing use (except for manufacturing as permitted in by the Permitted Use), (15) as studios for radio, television or other media or (16) for the production, testing, use, or disposal of any toxic chemicals. Furthermore,

  
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the Premises shall not be used for any purpose that would, in Landlord’s reasonable judgment, tend to lower the first-class character of a Building, create unreasonable or excessive elevator
or floor loads, violate the certificate of occupancy of a Building, impair or interfere with any of the Buildings’ operations or the proper and economic heating, air-conditioning, cleaning or any other services of a Building, interfere with the
use of the other areas of a Building by any other tenants, or impair the appearance of a Building. Notwithstanding clause (16) of the immediately preceding sentence, Tenant may use the Premises to produce, test or use those toxic chemicals which are
essential or incidental to the Tenant’s normal business operations, consistent with, and customary for, the operation of a non-military, commercial laboratory operated by Tenant and expressly permitted under all applicable Requirements and, if
required by any Requirements, a current and valid permit or certificate issued by the Government Authority. If the Premises is used as set forth in the immediately preceding sentence, Tenant shall do the following to reduce the safety hazards
associated with toxic chemicals: (a) use the highest standard of care in all activities involving toxic chemicals; (b) arrange the Premises in a manner to allow for adequate space and orderly placement of all toxic chemicals and equipment used in
connection with toxic chemicals; (c) separate or create a defined area within the Premises for the use, storage, production and/or testing of toxic chemicals; and (d) equip the Premises with the following items if necessary or prudent:
(i) supplemental lighting and ventilation, (ii) air-supply and exhaust filters, (iii) a system for monitoring environmental conditions, and (iv) any other items that are necessary, prudent or required by any applicable Requirements. 

Section 5.3 Landlord represents and warrants to Tenant that the current certificate of occupancy for the Buildings and insurance
requirements applicable to the insurance maintained by Landlord on the Buildings’ permit the uses of the Premises that are Permitted Uses. 
 ARTICLE 6 
 ALTERATIONS 

Section 6.1 (A) Subject to obtaining Landlord’s prior written consent, which consent shall not be unreasonably withheld or delayed,
Tenant may, from time to time, make any Alterations provided that: (i) the outside appearance of a Building shall not be affected; (ii) the strength of a Building shall not be affected; (iii) the structural parts of a Building shall
not be adversely affected; (iv) no part of a Building outside of the Premises shall be affected; and (v) the proper functioning of the Building Systems shall not be adversely affected and the use of such systems by Tenant shall not be
increased beyond Tenant’s allocable portion of the reserve 
 capacity thereof, if any. If consent to any Alterations is not given, Landlord
shall notify Tenant in sufficient detail to enable Tenant to amend its plans and specifications regarding such Alterations to comply with Landlord’s objections. Tenant may, without Landlord’s consent, but after written notice to Landlord,
perform decorative Alterations such as painting and carpeting. 
 (B) (1) Prior to making any Alterations, Tenant shall, at
Tenant’s expense, (i) submit to Landlord one set of mylar sepias and two sets of blue lines of final, stamped and detailed plans and specifications (including layout, architectural, electrical, mechanical and structural drawings) that
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Alteration without first obtaining Landlord’s approval of such plans and specifications which consent shall not be unreasonably withheld or delayed, (ii) obtain all permits, approvals and
certificates required by any Government Authorities, and (iii) furnish to Landlord duplicate original policies of worker’s compensation insurance (covering all persons to be employed by Tenant, and Tenant’s contractors and subcontractors,
in connection with such Alteration) and commercial general liability insurance (including premises operation, bodily injury, personal injury, death, independent contractors, products and completed operations, broad form contractual liability and
broad form property damage coverages) in such form, with such companies, for such periods and in such amounts as Landlord may reasonably approve, naming Landlord and its agents, any Lessor and any Mortgagee, as additional insureds. If Landlord
previously has provided Tenant or its architect with base building plans on a CADD disk, Tenant shall also submit Tenant’s plans and any changes thereto by disk. Upon completion of such Alteration, Tenant, at Tenant’s expense, shall obtain
certificates of final approval of such Alterations required by any Government Authority and shall furnish Landlord with copies thereof, together with the “as-built” plans and specifications for such Alterations. All Alterations shall be
made and performed in accordance with the plans and specifications therefor as approved by Landlord, all Requirements, the Tenant Criteria Manual for the Buildings and the Rules and Regulations. All materials and equipment to be incorporated in the
Premises as a result of any Alterations shall be first quality and no such materials or equipment shall be subject to any lien, encumbrance, chattel mortgage, title retention or security agreement, provided that Tenant may finance its trade fixtures
(and grant a security interest thereon to secure such financing) with an Institutional Lender if such financing is required by such lender to be paid in full during the Term. An “Institutional Lender” shall mean a savings bank, a
savings and loan association, a commercial bank, a finance company (such as CIT or GECC), a trust company, which is organized under the laws of the United States or Canada and subject to the supervision of the Comptroller of the Currency, the
Federal Reserve Board or a state banking superintendent or commissioners, an insurance company, an investment bank, a real estate mortgage investment conduit, a trustee in securitization, or any assignee of any thereof (which assignee must also be
an Institutional Lender) organized and existing under the laws of the United States or Canada, a real estate investment trust sponsored by an Institutional Lender (which is not another real estate investment trust), or a union, federal, state,
municipal or secular employee’s welfare, benefit, pension or retirement fund. Tenant shall deliver to Landlord, at the request of Landlord, which may be made at any time and from time to time, evidence of the outstanding amount of, and terms
of, such financing and the identity of the lender thereof. In addition, no such Alteration (except for the Tenant Improvements) for which the cost of labor and materials (as estimated by Landlord’s architect, engineer or contractor) is in
excess of One Million ($1,000,000) Dollars (excluding decorative items and Tenant’s trade fixtures), shall be undertaken prior to Tenant’s delivering to Landlord such security for timely lien-free completion thereof as is reasonably
satisfactory to Landlord, and such Alteration shall be performed only under the supervision of a licensed architect satisfactory to Landlord. Notwithstanding the foregoing, Landlord shall not require Tenant to deliver a completion bond or other
security in connection with Tenant’s initial Alterations or Tenant Improvements. Notwithstanding the provisions of subsection B(1)(i) of this Section 6.1, with respect to any Alterations for which the cost of labor and materials (as
estimated by Landlord’s architect or contractor) is less than Two Hundred Thousand ($200,000) Dollars, either individually or in the aggregate with any other Alterations constructed in any six (6) month period, Tenant shall not be obligated to
submit the detailed plans and specifications referred to in subsection (B)(1)(i) (unless required by any Requirements), but in lieu of such detailed plans and specifications, Tenant shall submit to Landlord five (5) sets of 

  
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 documentation sufficient adequately to inform Landlord and its architect and engineer of the Alterations
proposed to be made by Tenant. 
 (2) Landlord reserves the right to disapprove any plans and specifications in part, to reserve
approval of items shown thereon pending its review and approval of other plans and specifications, and to condition its approval upon Tenant making revisions to the plans and specifications or supplying additional information. Tenant agrees that any
review or approval by Landlord of any plans and/or specifications with respect to any Alteration is solely for Landlord’s benefit, and without any representation, warranty or liability whatsoever to Tenant or any other Person with respect to
the adequacy, correctness or sufficiency or with respect to Requirement or otherwise. Landlord agrees to grant its approval or disapproval of any plans, or revisions to plans, within ten (10) days of the date such plans are delivered to Landlord in
the form required by this Lease. 
 (C) Except as otherwise provided herein, Tenant shall be permitted to perform Alterations
during Operating Hours, provided that such work does not materially interfere with or interrupt the operation and maintenance of the Buildings (as determined by Landlord) or unreasonably interfere with or interrupt the use and occupancy of the
Buildings by any other tenants in the Buildings. Otherwise, Alterations shall be performed at such times and in such manner as Landlord may from time to time reasonably designate. All Alterations (including wiring and cabling from the raceways and
conduits located in the Premises) shall become a part of the Building and shall be Landlord’s property from and after the installation thereof and may not be removed or changed without Landlord’s consent. Notwithstanding the foregoing if,
on or before the date Landlord approves Tenant’s plans and specifications (or other documentation) for Alterations (including wiring and cabling), Landlord notifies Tenant that Landlord is reserving the right to require Tenant to remove the
same or any portion thereof, then Landlord prior to the Expiration Date, may require Tenant to remove all of such Alterations (including wiring and cabling) or any specified portion thereof and to repair and restore in a good and workmanlike manner
to Building standard condition (reasonable wear and tear excepted) any damage to the Premises or a Building caused by such removal. All Tenant’s Property shall remain the property of Tenant and, on or before the Expiration Date, may be removed
from the Premises by Tenant at Tenant’s option; provided, however, that Tenant shall repair and restore in a good and workmanlike manner any damage to the Premises or a Building caused by such removal. The provisions of this Section
6.1(C) shall survive the expiration or earlier termination of this Lease. 
 (D) All Alterations shall be performed, at
Tenant’s sole cost and expense, by contractors, subcontractors or mechanics approved by Landlord, such approval not to be unreasonably withheld or delayed. Prior to Tenant making any Alterations, Landlord or Manager, at Tenant’s request,
shall furnish Tenant with a list of contractors, subcontractors and mechanics who may perform Alterations in or to the Premises on behalf of Tenant. If Tenant shall enter, within six (6) months after Landlord shall furnish Tenant with such list,
into a contract with any contractor set forth on the list, Tenant shall not be required to obtain Landlord’s consent to such contractor unless, prior to entering into a contract with such contractor or the commencement of work by the
contractor, Landlord notifies Tenant that such contractor has been removed from the list. 
 (E) (1) Any mechanic’s lien
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Tenant shall be cancelled or discharged by Tenant, by payment or filing of the bond required by law, within twenty-five (25) days after such lien shall be filed, and Tenant shall indemnify and
hold Landlord harmless from and against any and all costs, expenses, claims, losses or damages resulting therefrom by reason thereof. 
 (2) If Tenant shall fail to discharge such mechanic’s lien within the aforesaid period, then, in addition to any other right or remedy of Landlord, Landlord may, but shall not be obligated to,
discharge the same either by paying the amount claimed to be due or by procuring the discharge of such lien by deposit in court or bonding, and in any such event, Landlord shall be entitled, if Landlord so elects, to compel the prosecution of an
action for the foreclosure of such mechanic’s lien by the lienor and to pay the amount of the judgment, if any, in favor of the lienor, with interest, costs and allowances. 

(3) Any amount paid by Landlord for any of the aforesaid charges and for all expenses of Landlord (including, but not limited to,
attorneys’ fees and disbursements) incurred in defending any such action, discharging said lien or in procuring the discharge of said lien, with interest on all such amounts at the maximum legal rate of interest then chargeable to Tenant from
the date of payment, shall be repaid by Tenant within ten (10) days after written demand therefor, and all amounts so repayable, together with such interest, shall be considered Additional Rent. 

Section 6.2 Tenant shall reimburse Landlord, within five (5) Business Days after demand therefor, for any out-of-pocket expense incurred
by Landlord for reviewing the plans and specifications for any Alterations or inspecting the progress of completion of the same. 
 Section 6.3 Tenant shall furnish to Landlord copies of records of all Alterations and of the cost thereof within fifteen (15) days after request by Landlord after the completion of such Alterations.

 Section 6.4 Tenant shall not, at any time prior to or during the Term, directly or indirectly employ, or permit the
employment of, any contractor, mechanic or laborer in the Premises, whether in connection with any Alteration or otherwise, if such employment would interfere or cause any conflict with other contractors, mechanics or laborers engaged in the
construction, maintenance or operation of a Building or the Project by Landlord, Tenant or others, or of any other property owned by Landlord. In the event of any such interference or conflict, Tenant, upon demand of Landlord, shall use best efforts
to cause all contractors, mechanics or laborers causing such interference or conflict to leave the Buildings immediately. Notwithstanding the foregoing, Tenant shall have the right to use union or non-union contractors to the extent permitted by the
Requirements. 
 ARTICLE 7 
 REPAIRS; FLOOR LOAD 
 Section 7.1 Tenant, at Tenant’s sole cost and
expense, shall take good care of the Premises and the fixtures, equipment and appurtenances therein (including without limitation, any restrooms within the Premises) and make all repairs thereto as and when needed to preserve

  
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them in good working order and condition, except for (a) reasonable wear and tear, (b) obsolescence and (c) damage for which Tenant is not responsible pursuant to the provisions of Article
13. Except as otherwise provided in this Section 7.1, Tenant shall not be obligated to repair any Building Systems. The design and decoration of the elevator areas of each floor of the Premises and the public corridors of any floor of the
Premises occupied by more than one (1) occupant shall be under the sole control of Landlord. Notwithstanding any provision contained in this Lease to the contrary, all damage or injury to the Premises, and all damage or injury to any other part of a
Building, or to its fixtures, equipment and appurtenances (including Building Systems), whether requiring structural or non-structural repairs, caused by the moving of Tenant’s Property or caused by or resulting from any act or omission of, or
Alterations made by, Tenant or Persons Within Tenant’s Control, shall be repaired by Tenant, at Tenant’s sole cost and expense, to the reasonable satisfaction of Landlord (if the required repairs are non-structural in nature and do not
affect any Building Systems), or by Landlord at Tenant’s sole cost and expense (if the required repairs are structural in nature or affect any Building Systems). All of the aforesaid repairs shall be performed in a manner and with materials and
design of first class and quality consistent with first-class office buildings in Westchester County and shall be made in accordance with the provisions of Article 6. If Tenant shall fail, after ten (10) days notice (or such shorter period as
may be required because of an emergency), to proceed with due diligence to make repairs required to be made by Tenant, the same may be made by Landlord, at the expense of Tenant, and the expenses thereof incurred by Landlord, with interest thereon
at the Applicable Rate, shall be paid to Landlord, as Additional Rent, within ten (10) days after rendition of a bill or statement therefor. Tenant shall give Landlord prompt notice of any defective condition in any Building Systems located in,
servicing or passing through the Premises upon Tenant becoming aware of same. 
 Section 7.2 Tenant shall not place a load upon
any floor of the Premises which exceeds the load with such floor was designed to carry and which is allowed by law. If Tenant is moving or locating any safe, machinery, equipment, freight, bulky matter or fixture which requires special handling (as
determined by Landlord), Tenant shall employ only persons holding a Master Rigger’s license to do said work. All work in connection therewith shall comply with the Requirements, and shall be done during such hours as Landlord may reasonably
designate. Business machines and mechanical equipment shall be placed and maintained by Tenant, at Tenant’s expense, in settings sufficient, in Landlord’s reasonable judgment, to absorb and prevent vibration, noise and annoyance.

 Section 7.3 Landlord shall (subject to Tenant’s reimbursement obligation pursuant to Article 4) operate, maintain
and make all necessary repairs (both structural and non-structural) to the Building Systems and the public portions of the Buildings, both exterior and interior, in conformance with standards applicable to first-class office buildings in Westchester
County, except for those repairs for which Tenant is responsible pursuant to any other provision of this Lease. Landlord acknowledges that Tenant’s business involves manufacturing processes that are required to run uninterrupted for extended
periods beyond customary business hours and that Tenant will incur substantial additional cost and expense if such manufacturing “runs” are interrupted. Landlord shall use reasonable efforts to minimize interference with Tenant’s use
and occupancy of the Premises in making any repairs, alterations, additions or improvements and shall, except in the case of an emergency, attempt to coordinate with Tenant in making any repairs, alterations, additions or improvements so as to
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 obligation to employ contractors or labor at so-called overtime or other premium pay rates or to incur any
other overtime costs in connection with such repairs, alterations, additions or improvements. Notwithstanding the foregoing, if Tenant shall so request, Landlord shall employ contractors or labor at so-called overtime or other premium pay rates or
incur other overtime costs in making such repairs, alterations, additions or improvements, provided Tenant shall pay to Landlord, as Additional Rent, within ten (10) days after demand therefor, an amount equal to the excess costs incurred by
Landlord by reason of compliance with Tenant’s request. Except as expressly provided in this Lease, there shall be no allowance to Tenant for a diminution of rental value and no liability on the part of Landlord by reason of inconvenience,
annoyance or injury to business arising from Landlord, Tenant or others making, or failing to make, any repairs, alterations, additions or improvements in or to any portion of a Building or the Premises, or its fixtures, appurtenances or equipment.

 ARTICLE 8 
 WINDOW CLEANING 
 Section 8.1 Tenant shall not clean, nor require,
permit, suffer or allow any window in the Premises to be cleaned, from the outside in violation of Section 202 of the Labor Law, or any other applicable law, or of any other board or body having jurisdiction. 

ARTICLE 9 

REQUIREMENTS OF LAW 
 Section 9.1 Tenant shall not do, and shall not permit Persons Within Tenant’s Control to do, any act or thing in or upon the Premises or a Building which will invalidate or be in conflict with
the certificate of occupancy for the Premises or a Building or violate any Requirements. Tenant shall, at Tenant’s sole cost and expense, take all action, including any required Alterations necessary to comply with all Requirements (including,
but not limited to, applicable terms of the Americans With Disabilities Act of 1990 (the “ADA”), as modified and supplemented from time to time) which shall impose any violation, order or duty upon Landlord or Tenant arising from, or in
connection with, the Premises, Tenant’s occupancy, use or manner of use of the Premises (including, without limitation, any occupancy, use or manner of use that constitutes a “place of public accommodation” under the ADA), or any
installations in the Premises, or required by reason of a breach of any of Tenant’s covenants or agreements under this Lease, whether or not such Requirements shall now be in effect or hereafter enacted or issued, and whether or not any work
required shall be ordinary or extraordinary or foreseen or unforeseen at the date hereof. Notwithstanding the preceding sentence, Tenant shall not be obligated to perform any Alterations necessary to comply with any Requirements, unless compliance
shall be required by reason of (i) any cause or condition arising out of any Alterations or installations in the Premises (whether made by Tenant or by Landlord on behalf of Tenant), or (ii) Tenant’s particular use, manner of use or
occupancy on behalf of Tenant of the Premises (as opposed to mere laboratory and office use), or (iii) any breach of any of Tenant’s covenants or agreements under this Lease, or (iv) any wrongful act or omission by Tenant or Persons
Within Tenant’s Control, or (v) Tenant’s use or manner of use or occupancy of the 

  
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Premises as a “place of public accommodation” within the meaning of the ADA, in which event Tenant’s obligation to perform any Alteration by reason of this clause (v) shall
apply only to the Premises. 
 (A) Landlord shall, at Landlord’s sole cost and expense, take all action necessary to comply
with all Requirements (including, but not limited to, applicable terms of the ADA), which shall impose any violation, order or duty upon Landlord or Tenant arising from, or in connection with, the Landlord Improvements, the common elevators in the
Buildings and other common area of the Buildings of which Landlord has the responsibility to maintain hereunder. 

Section 9.2 Tenant covenants and agrees that Tenant shall, at Tenant’s sole cost and expense, comply at all times with all
Requirements governing the use, generation, storage, treatment and/or disposal of any Hazardous Materials (as defined below), the presence of which results from or in connection with the act or omission of Tenant or Persons Within Tenant’s
Control or the breach of this Lease by Tenant or Persons Within Tenant’s Control. The term “Hazardous Materials” shall mean any biologically or chemically active or other toxic or hazardous wastes, pollutants or substances,
including, without limitation, asbestos, PCBs, petroleum products and by-products, substances defined or listed as “hazardous substances” or “toxic substances” or similarly identified in or pursuant to the Comprehensive
Environmental Response, Compensation and Liability Act, 42 U.S.C. § 9601 et seq., and as hazardous wastes under the Resource Conservation and Recovery Act, 42 U.S.C. § 6010, et seq., any chemical substance or
mixture regulated under the Toxic Substance Control Act of 1976, as amended, 15 U.S.C. § 2601, et seq., any “toxic pollutant” under the Clean Water Act, 33 U.S.C. § 466 et seq., as amended, any
hazardous air pollutant under the Clean Air Act, 42 U.S.C. § 7401 et seq., hazardous materials identified in or pursuant to the Hazardous Materials Transportation Act, 49 U.S.C. § 1802, et seq., and any
hazardous or toxic substances or pollutant regulated under any other Requirements. Tenant shall agree to execute, from time to time, at Landlord’s request, representations and the like concerning Tenant’s best knowledge and belief
regarding the presence of Hazardous Materials in, on, under or about the Premises, the Buildings or the Land. Tenant shall indemnify and hold harmless all Indemnitees from and against any loss, cost, damage, liability or expense (including
attorneys’ fees and disbursements) arising by reason of any clean up, removal, remediation, detoxification action, diminution in value of the Premises, damages for the loss or amenity of the Premises or any other activity required or
recommended of any Indemnitees by any Government Authority by reason of the presence in or about the Buildings or the Premises of any Hazardous Materials, as a result of or in connection with the act or omission of Tenant or Persons Within
Tenant’s Control or the breach of this Lease by Tenant or Persons Within Tenant’s Control. Without limiting the foregoing, if any Hazardous Materials attributable to Tenant or Persons Within Tenant’s Control, or the activities of any
of them, are being used, stored, generated, or tested under or about the Premises in a manner that violates any Requirement, Tenant shall promptly take all actions, at its sole cost and expense, necessary to comply with all Requirements; provided
that, except in emergency situations (in which case Notice shall be given to Landlord as soon as practicable), Landlord’s approval of such actions shall first be obtained, which approval shall not be unreasonably withheld or delayed. The
foregoing covenants and indemnity shall survive the expiration or any termination of this Lease. Tenant shall, upon becoming aware of same, give prompt written notice to Landlord of (i) any condition in or near the Premises that shall pose a
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respect to the presence of any Hazardous Materials in, from or about the Premises, (iii) all claims made or threatened by any third party (including any Government Authority) against Tenant
or any party occupying the Premises relating to any loss or injury resulting from any Hazardous Materials in the Premises, and (iv) Tenant’s discovery of any occurrence or condition in the Premises, the Buildings or the Project that
reasonably could cause the Buildings or the Project to be subject to any investigation or cleanup pursuant to any Requirement. 

Section 9.3 If Tenant shall receive notice of any violation of, or defaults under, any Requirements, liens or other encumbrances
applicable to the Premises, Tenant shall give prompt notice thereof to Landlord. 
 Section 9.4 If any governmental license
or permit shall be required for the proper and lawful conduct of Tenant’s business and if the failure to secure such license or permit would, in any way, adversely affect Landlord, the Buildings or the Project, then Tenant, at Tenant’s
expense, shall promptly procure and thereafter maintain, submit for inspection by Landlord, and at all times comply with the terms and conditions of, each such license or permit. 

Section 9.5 Tenant, at Tenant’s sole cost and expense and after notice to Landlord, may contest, by appropriate proceedings
prosecuted diligently and in good faith, the legality or applicability of any Requirement affecting the Premises provided that: (a) neither Landlord nor any Indemnitees shall be subject to criminal penalties, nor shall the Real Property or any
part thereof be subject to being condemned or vacated, nor shall the certificate of occupancy for the Premises or the Buildings be suspended or threatened to be suspended, by reason of non-compliance or by reason of such contest; (b) before the
commencement of such contest, if Landlord or any Indemnitees may be subject to any civil fines or penalties or if Landlord may be liable to any independent third party as a result of such non-compliance, then Tenant shall furnish to Landlord either
(i) a bond of a surety company satisfactory to Landlord, in form and substance reasonably satisfactory to Landlord, and in an amount equal to one hundred twenty percent (120%) of Landlord’s reasonable estimate of the sum of
(A) the cost of such compliance, (B) the penalties or fines that may accrue by reason of such non-compliance (as reasonably estimated by Landlord) and (C) the amount of such liability to independent third parties, and shall indemnify
Landlord (and any Indemnitees) against the cost of such compliance and liability resulting from or incurred in connection with such contest or non-compliance; or (ii) other security reasonably satisfactory in all respects to Landlord;
(c) such non-compliance or contest shall not constitute or result in a violation (either with the giving of notice or the passage of time or both) of the terms of any Mortgage or Superior Lease, or if such Superior Lease or Mortgage conditions
such non-compliance or contest upon the taking of action or furnishing of security by Landlord, such action shall be taken or such security shall be furnished at the expense of Tenant; and (d) Tenant shall keep Landlord regularly advised as to
the status of such proceedings. 
 Section 9.6 (A) Landlord may, at its option and at Landlord’s expense, cause
to be performed on or before the Commencement Date and provide to Tenant a phase I environmental assessment of the Premises, together with such additional reports and testing (including a phase II environmental assessment), if necessary in
Landlord’s sole discretion from an environmental consultant selected by Landlord (the “Initial Environmental Audit”). 
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 termination of this Lease, Landlord may obtain a phase I environmental assessment of the Premises, together
with such additional reports and testing (including a phase II environmental assessment) if necessary in Landlord’s sole discretion using the consultant who initially prepared the Initial Environmental Audit, or if that consultant is
unavailable or, if an Initial Environmental Audit had not been conducted, another licensed environmental consultant reasonably acceptable to Landlord, to determine the environmental status of the Premises as of the date of that environmental update
(the “Environmental Update”). The cost of the foregoing environmental assessment shall be divided evenly between the Landlord and Tenant, except if any Hazardous Material remediation work is required as a result of Tenant’s
acts or omissions, Tenant shall bear the entire cost of such environmental assessment and shall be entitled to receive a copy of all such assessment reports. Tenant shall pay to Landlord any amounts payable hereunder within fifteen (15) days after
being billed therefor. 
 (C)    Tenant’s obligations under Section 9.2 of this Lease shall also
apply to any Hazardous Materials which are revealed by the Environmental Update (or any inspection by Landlord prior to Tenant’s delivery of the Premises to Landlord), but which were not revealed by the Initial Environmental Audit. This
Section 9.6 shall survive the expiration or sooner termination of this Lease. 
 Section
9.7    (A)    At any time prior to the Expiration Date or sooner termination of this Lease or to any assignment of this Lease or any subletting of any portion of the Premises, Landlord, in its sole discretion,
may inspect or cause the inspection of the Premises for the purpose of determining whether or not Tenant is in compliance with this Article 9 and whether or not to conduct more detailed inspection, sampling and testing of the Premises to
determine whether all Hazardous Materials are being used, stored, generated or tested in accordance with all Requirements. 

(B)    If as a result of any inspection, sampling or testing, it is determined that there exists upon the Premises
Hazardous Materials other than in compliance with this Lease and all Requirements, then, Tenant shall, at its sole cost and expense, immediately comply with the fifth sentence in Section 9.2 and all other Articles of this Lease as applicable
and appropriate. 
 (C)    Tenant shall fully cooperate with Landlord in connection with any rules and
regulations of Landlord regarding Tenant’s use, production or storage of Hazardous Materials upon the Premises including, but not limited to, promptly completing and returning to Landlord any questionnaires regarding Hazardous Materials.

 (D)    All of Landlord’s costs in reviewing the inspection and sampling plan and test results and
developing a plan for and monitoring the cleanup and site detoxification, shall be paid by Tenant, as Additional Rent, within twenty (20) days after receipt of an invoice therefor. 

Section 9.8    Landlord represents and warrants to Tenant that, to Landlord’s actual knowledge, there is no
asbestos in the Premises or the public areas of the Buildings, except for the possible presence of asbestos in certain pipes, which is either encapsulated or is not in friable condition. If it is hereafter determined that asbestos which is present
in the Premises on the Commencement Date is friable and not disturbed by Alterations to be made by Tenant in accordance herewith, then, provided Tenant is not in default hereunder beyond applicable notice and grace and the need for removal or
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 the negligent or wrongful acts or omissions of Tenant or its agent, subtenant, employee, contractor or
invitee, Landlord shall promptly at its expense, remove or (provided Tenant’s permitted Alternations will not be materially adversely affected thereby) encapsulate such asbestos in accordance with applicable Requirements. Landlord shall perform
such work in a manner as to have the least practicable interference with Tenant’s use and operations in the Premises, recognizing Tenant’s sensitive laboratory work. 
 ARTICLE 10 
 SUBORDINATION 

Section 10.1    Subject to the provisions in Section 10.5 below, this Lease shall be subject and subordinate
to each Superior Lease and to each Mortgage, whether made prior to or after the execution of this Lease, and to all renewals, extensions, supplements, amendments, modifications, consolidations and replacements thereof or thereto, substitutions
therefor, and advances made thereunder. This clause shall be self-operative and no further agreement of subordination shall be required to make the interest of any Lessor or Mortgagee superior to the interest of Tenant hereunder. In confirmation of
such subordination, however, Tenant shall promptly execute and deliver, at its own cost and expense, any document, in recordable form if requested, that Landlord, any Lessor or any Mortgagee may request to evidence such subordination; and if Tenant
fails to execute, acknowledge or deliver any such document within ten (10) days after request thereof, Tenant hereby irrevocably constitutes and appoints Landlord as Tenant’s attorney-in-fact, coupled with an interest, to execute, acknowledge
and deliver any such document for and on behalf of Tenant. Tenant shall not knowingly do anything that would constitute a default under any Superior Lease or Mortgage, or omit to do anything that Tenant is obligated to do under the terms of this
Lease so as to cause Landlord to be in default thereunder. If, in connection with the financing of the Real Property, the Buildings or the interest of the lessee under any Superior Lease, or if, in connection with the entering into of a Superior
Lease, any lending institution or Lessor, as the case may be, requests reasonable modifications of this Lease that do not increase rent or change the Term of this Lease, or materially and adversely affect the rights or obligations of Tenant under
this Lease, Tenant shall make such modifications. 
 Section 10.2    If, at any time prior to the expiration
of the Term, any Superior Lease shall terminate or shall be terminated for any reason, or any Mortgagee comes into possession of the Real Property or the Buildings or the estate created by any Superior Lease by receiver or otherwise, Tenant agrees,
subject to the provisions in Section 10.5 below, at the election and upon demand of any owner of the Real Property or the Buildings, or of the Lessor, or of any Mortgagee in possession of the Real Property or the Buildings, to attorn, from
time to time, to any such owner, Lessor or Mortgagee or any person acquiring the interest of Landlord as a result of any such termination, or as a result of a foreclosure of the Mortgage or the granting of a deed in lieu of foreclosure, upon the
then executory terms and conditions of this Lease (except as provided below), for the remainder of the Term, provided that such owner, Lessor or Mortgagee, as the case may be, or receiver caused to be appointed by any of the foregoing, is then
entitled to possession of the Premises. Provided that in the event of any conflict between the applicable Non-Disturbance Agreement (as hereinafter defined) and this Section 10.2, the applicable Non-Disturbance Agreement shall govern and
control any such attornment shall be made upon the condition that no such owner, Lessor or Mortgagee shall be: 

  
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 (1)    liable for any act or omission of any prior landlord (including
without limitation, the then defaulting landlord) although such owner, Lessor or Mortgagee shall be obligated to correct any conditions existing at the date of attornment which violate such party’s obligations as Landlord hereunder; or

 (2)    subject to any defense or offsets (except as expressly set forth in this Lease) which Tenant may
have against any prior landlord (including without limitation, the then defaulting landlord); or 

(3)    bound by any payment of Rental which Tenant might have paid for more than the current month to any prior
landlord (including, without limitation, the then defaulting landlord), except for refunds or credits of Taxes or Operating Expenses due to Tenant; or 
 (4)    bound by any amendment, modification, surrender or termination of this Lease made without Lessor’s or Mortgagee’s prior written consent. 

The provisions of this Section 10.2 shall inure to the benefit of any such owner, Lessor or Mortgagee, shall apply notwithstanding
that, as a matter of law, this Lease may terminate upon the termination of any such Superior Lease, and shall be self-operative upon any such demand, and no further agreement shall be required to give effect to said provisions. Subject to the
provisions of Section 10.5 below, Tenant, however, upon demand of any such owner, Lessor or Mortgagee, shall execute, from time to time, agreements in confirmation of the foregoing provision of this Section 10.2, satisfactory to any
such owner, Lessor or Mortgagee, and acknowledging such attornment and setting forth the terms and conditions of its tenancy. Nothing contained in this Section 10.2 shall be construed to impair any right otherwise exercisable by any such
owner, Lessor or Mortgagee. 
 Section 10.3    At any time and from time to time upon ten (10) days’
prior notice to Tenant by Landlord or a Lessor or Mortgagee (which ten (10) day period is not subject to any notice and cure periods otherwise provided in this Lease), Tenant shall, without charge, execute, acknowledge and deliver a statement in
writing addressed to such party as Landlord, Lessor or Mortgagee, as the case may be, may designate, in form satisfactory to Landlord, Lessor or Mortgagee, as the case may be, certifying all or any of the following: (i) that this Lease is
unmodified and in full force and effect (or if there have been modifications, that this Lease is in full force and effect as modified and stating the modifications); (ii) whether the Term has commenced and Fixed Rent and Additional Rent have
become payable hereunder and, if so, the dates to which they have been paid; (iii) whether or not, to the best knowledge of the signer of such certificate, Landlord is in default in performance of any of the terms of this Lease and, if so,
specifying each such Event of Default of which the signer may have knowledge; (iv) whether Tenant has accepted possession of the Premises; (v) whether Tenant has made any claim against Landlord under this Lease and, if so, the nature
thereof and the dollar amount, if any, of such claim; (vi) either that Tenant does not know of any default in the performance of any provision of this Lease or specifying the details of any default of which Tenant may have knowledge and stating
what action Tenant is taking or proposes to take with respect thereto; (vii) that, to the knowledge of Tenant, there is no proceedings pending or threatened against Tenant before or by any court or administrative agency which, if adversely
decided, would materially and adversely affect the financial condition or operations of Tenant or, if any such proceedings are 

  
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 pending or threatened to the knowledge of Tenant, specifying and describing the same; and (viii) such
further information with respect to this Lease or the Premises as Landlord may reasonably request or Lessor or Mortgagee may require; it being intended that any such statement delivered pursuant hereto may be relied upon by any prospective purchaser
of the Real Property or any part thereof or of the interest of Landlord in any part thereof, by any Mortgagee or prospective Mortgagee, by any Lessor or prospective Lessor, by any tenant or prospective tenant of the Real Property or any part
thereof, or by any prospective assignee of any Mortgage. 
 The failure of Tenant to execute, acknowledge and deliver to
Landlord a statement in accordance with the provisions of this Section 10.3 within said ten (10) day period shall constitute an acknowledgement by Tenant, which may be relied on by any person who would be entitled to rely upon any such
statement, that such statement as submitted by Landlord is true and correct. 
 Section 10.4    As long as
any Superior Lease or Mortgage exists, Tenant shall not seek to terminate this Lease by reason of any act or omission of Landlord until Tenant has given written notice of such act or omission to all Lessors and Mortgagees at such addresses as may
have been furnished to Tenant by such Lessors and Mortgagees and, if any such Lessor or Mortgagee, as the case may be, notifies Tenant within thirty (30) days following receipt of such notice of its intention to remedy such act or omission using
diligent and continuous efforts, until a reasonable period of time shall have elapsed following the giving of such notice, provided that during such period such Lessors and Mortgagees shall diligently and continuously pursue the remedy of such act
or omission, which such Lessors and Mortgagees shall have the right, but not the obligation, to do. 
 Section
10.5    (A) As used in this Article 10, the term Non-Disturbance Agreement shall mean an agreement in recordable form that provides in substance that, so long as Tenant shall not then be in default in the performance
of any of its obligations under this Lease beyond any period provided for herein for the cure of such default, Tenant’s possession of the Premises in accordance with this Lease shall not be disturbed by such person giving the non-disturbance
agreement or any successor or purchaser at a foreclosure sale (as the case may be) which shall succeed to the rights of Landlord under this Lease. Such agreement shall be in such form as is customarily used by the Mortgagee or Lessor if it is an
institutional lender. Tenant shall reimburse Landlord upon demand for any and all costs and expenses (including, without limitation, reasonable attorneys’ fees and disbursements) incurred or payable by Landlord in connection with obtaining each
such non-disturbance agreement. 
 (B)    With respect to any Mortgage, the provisions of Section
10.1 of this Lease shall only operate to subject and subordinate this Lease to the Mortgage if the holder of the Mortgage shall furnish a Non-Disturbance Agreement to Tenant. 

(C)    Landlord represents and warrants to Tenant that, as of the Execution Date, Landlord is the owner of the Land
and the Buildings in fee simple absolute and there are currently no Superior Leases or Mortgages in existence. 

  
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 ARTICLE 11 
 RULES AND REGULATIONS 
 Section 11.1 Tenant and Persons Within
Tenant’s Control shall comply with the Rules and Regulations. Nothing contained in this Lease shall be construed to impose upon Landlord any duty or obligation to enforce the Rules and Regulations or the terms, covenants or conditions in any
other lease against any other tenant, and Landlord shall not be liable to Tenant for violation of the same by any other tenant, its employees, agents, visitors or licensees. Landlord shall not discriminate against Tenant in enforcing the Rules and
Regulations. In case of any conflict or inconsistency between the provisions of this Lease and of any of the Rules and Regulations as originally or as hereinafter adopted, the provisions of this Lease shall control. 

ARTICLE 12 

INSURANCE, PROPERTY LOSS OR DAMAGE; REIMBURSEMENT 
 Section 12.1 (A) No Tenant shall entrust any property to any Building employee. Any Building employee to whom any property is entrusted by or on behalf of Tenant in violation of the foregoing
prohibition shall be deemed to be acting as Tenant’s agent with respect to such property and neither Landlord nor its agents shall be liable for any damage to property of Tenant or of others entrusted to employees of the Buildings, nor for the
loss of or damage to any property of Tenant by theft or otherwise. Landlord and Landlord’s agents shall not be liable for any damage to any of Tenant’s Property or for interruption of Tenant’s business caused by other tenants or
persons in the Buildings. Landlord shall not be liable for any latent defect in the Premises or in the Buildings. 
 (B) If at
any time any windows of the Premises are temporarily closed, darkened or covered for any reason, including Landlord’s own acts if reasonably necessary in connection with the operation of the Project, or if any such windows are permanently
closed, darkened or covered by reason of any Requirements, Landlord shall not be liable for any damage Tenant may sustain thereby, and Tenant shall not be entitled to any compensation therefor nor abatement of Fixed Rent or any other item of Rental,
nor shall the same release Tenant from Tenant’s obligations hereunder nor constitute an eviction. Except in case of emergency, Landlord shall give Tenant reasonable prior written notice of any such closure or darkening. 

(C) Tenant shall give notice to Landlord promptly after Tenant learns of any accident, emergency, occurrence for which Landlord might be
liable, fire or other casualty and all damages to or defects in the Premises or the Buildings for the repair of which Landlord might be responsible or which constitutes Landlord’s property. Such notice shall be given by telecopy or personal
delivery to the address(es) of Landlord in effect for notice. 
 Section 12.2 Tenant shall not do or permit to be done any
act or thing in or upon the Premises which will invalidate or be in conflict with the terms of the New York State standard policies of fire insurance and liability (hereinafter referred to as “Building Insurance”); and Tenant, at
Tenant’s own expense, shall comply with all rules, orders, regulations and requirements of all insurance boards, and shall not do or permit anything to be done in or upon 

  
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the Premises or bring or keep anything therein or use the Premises in a manner which increases the rate of premium for any of the Building Insurance over the rate in effect at the commencement of
the Term of this Lease. 
 Section 12.3 If by reason of any failure of Tenant to comply with the provisions of this Lease,
the rate of premium for Building Insurance or other insurance on the property and equipment of Landlord shall increase, Tenant shall reimburse Landlord for that part of the insurance premiums thereafter paid by Landlord which shall have been charged
because of such failure by Tenant. Tenant shall make said reimbursement on the first day of the month following such payment by Landlord and receipt of notice thereof. 
 Section 12.4 (A) At Tenant’s own cost and expense, Tenant shall obtain, maintain and keep in full force and effect during the Term commercial general liability insurance (without
deductible) in a form approved in New York State (including broad form property damage coverages). The limits of liability shall be not less than Five Million and 00/100 ($5,000,000.00) Dollars per occurrence, which amount may be satisfied with a
primary commercial general liability policy of not less than $1,000,000.00 and an excess (or “Umbrella”) liability policy affording coverage, at least as broad as that afforded by the primary commercial general liability policy, in
an amount not less than $4,000,000.00. Landlord, BioMed Realty Trust, Inc., BioMed Realty, L.P., the Manager, any Lessors and any Mortgagees shall be included as additional insureds in said policies and shall be protected against all liability
arising in connection with this Lease. All said policies of insurance shall be written as “occurrence” policies. Whenever, in Landlord’s reasonable judgment, good business practice and changing conditions indicate a need for
additional amounts or different types of insurance coverage, Tenant shall, within ten (10) days after Landlord’s request, obtain such insurance coverage, at Tenant’s expense. 

(B) Tenant, at Tenant’s sole cost and expense, shall maintain all-risk insurance, with deductibles in an amount reasonably
satisfactory to Landlord, protecting and indemnifying Tenant against any and all damage to or loss of any Alterations and leasehold improvements, including any made by Landlord to prepare the Premises for Tenant’s occupancy and Tenant’s
Property. All said policies shall cover the full replacement value of all Alterations, leasehold improvements and Tenant’s Property. 
 (C) All policies of insurance shall be: (i) written as primary policy coverage and not contributing with or in excess of any coverage which Landlord or any Lessor may carry; and (ii) issued by
reputable and independent insurance companies rated in Best’s Insurance Guide or any successor thereto (or, if there is none, an organization having a national reputation), as having a general policyholder rating of “A” and a
financial rating of at least “10”, and which are licensed to do business in the State of New York or otherwise reasonably acceptable to Landlord. Tenant shall, not later than ten (10) Business Days prior to the Commencement Date,
deliver to Landlord certificates the policies of insurance and shall thereafter furnish to Landlord, at least thirty (30) days prior to the expiration of any such policies and any renewal thereof, a certificate of the new policy in lieu
thereof. Each of said policies shall also contain a provision whereby the insurer agrees not to cancel, fail to renew, diminish or materially modify said insurance policy(ies) without having given Landlord, the Manager and any Lessors and Mortgagees
at least thirty (30) days prior written notice thereof. Tenant shall promptly send to Landlord a copy of all notices sent to Tenant by Tenant’s insurer. Upon request from Landlord, tenant shall deliver copies of the policies of insurance
for which certificates were delivered to Landlord. 

  
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 (D) Tenant shall pay all premiums and charges for all of said policies, and, if Tenant shall
fail to make any payment when due or carry any such policy, Landlord may, but shall not be obligated to, make such payment or carry such policy, and the amount paid by Landlord, with interest thereon (at the Applicable Rate), shall be repaid to
Landlord by Tenant on demand, and all such amounts so repayable, together with such interest, shall be deemed to constitute Additional Rent hereunder. Payment by Landlord of any such premium, or the carrying by Landlord of any such policy, shall not
be deemed to waive or release the default of Tenant with respect thereto. 
 Section 12.5 (A) Landlord shall cause
each policy carried by Landlord insuring the Buildings against loss, damage or destruction by fire or other casualty, and Tenant shall cause each insurance policy carried by Tenant and insuring the Premises and Tenant’s Alterations, leasehold
improvements and Tenant’s Property against loss, damage or destruction by fire or other casualty, to be written in a manner so as to provide that the insurance company waives all rights of recovery by way of subrogation against Landlord, Tenant
and any tenant of space in the Buildings in connection with any loss or damage covered by any such policy. Neither party shall be liable to the other for the amount of such loss or damage which is in excess of the applicable deductible, if any,
caused by fire or any of the risks enumerated in its policies, provided that such waiver was obtainable at the time of such loss or damage. However, if such waiver cannot be obtained, or shall be obtainable only by the payment of an additional
premium charge above that which is charged by companies carrying such insurance without such waiver of subrogation, then the party undertaking to obtain such waiver shall notify the other party of such fact and such other party shall have a period
of ten (10) days after the giving of such notice to agree in writing to pay such additional premium if such policy is obtainable at additional cost (in the case of Tenant, pro rata in proportion of Tenant’s rentable area to the total
rentable area covered by such insurance); and if such other party does not so agree or the waiver shall not be obtainable, then the provisions of this Section 12.5 shall be null and void as to the risks covered by such policy for so long
as either such waiver cannot be obtained or the party in whose favor a waiver of subrogation is desired shall refuse to pay the additional premium. If the release of either Landlord or Tenant, as set forth in the second sentence of this
Section 12.5, shall contravene any law with respect to exculpatory agreements, the liability of the party in question shall be deemed not released, but no action or rights shall be sought or enforced against such party unless and until
all rights and remedies against the other’s insurer are exhausted and the other party shall be unable to collect such insurance proceeds. 
 (B) The waiver of subrogation referred to in Section 12.5(A) above shall extend to the agents and employees of each party (including, as to Landlord, the Manager), but only if and to the
extent that such waiver can be obtained without additional charge (unless such party shall pay such charge). Nothing contained in this Section 12.5 shall be deemed to relieve either party from any duty imposed elsewhere in this Lease to
repair, restore and rebuild. 

  
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 ARTICLE 13 
 DESTRUCTION BY FIRE OR OTHER CAUSE 
 Section 13.1 If the Premises or
any part thereof shall be damaged by fire or other casualty, Tenant shall give prompt written notice thereof to Landlord. Landlord shall, subject to the provisions of Sections 13.2 and 13.3 below, proceed with reasonable diligence,
after receipt of, and subject to obtaining, the net proceeds of insurance, to repair or cause to be repaired such damage at its expense, but such repair obligation shall be limited to the core and structural core and perimeter walls only, with
access available to the Premises; and, if the Premises, or any part thereof, shall be rendered untenantable by reason of such damage and such damage shall not be due to the fault of Tenant or Persons Within Tenant’s Control, then the Fixed Rent
and the Additional Rent payable pursuant to Articles 3 and 4, or an amount thereof apportioned according to the area of the Premises so rendered untenantable (if less than the entire Premises shall be so rendered untenantable), shall be
abated for the period from the date of such damage to the date when the repair of such damage shall have been substantially completed. Tenant covenants and agrees to cooperate with Landlord and any Lessor or any Mortgagee in their efforts to collect
insurance proceeds (including rent insurance proceeds) payable to such parties. Landlord shall not be liable for any delay which may arise by reason of adjustment of insurance on the part of Landlord and/or Tenant, or any cause beyond the control of
Landlord or contractors employed by Landlord. Tenant shall, after Landlord shall have substantially completed its repair obligations, repair all damage to Tenant’s Property, Tenant’s Alterations and all leasehold improvements in the
Premises. 
 Section 13.2 Landlord shall not be liable for any inconvenience or annoyance to Tenant or injury to the
business of Tenant resulting in any way from damage from fire or other casualty or the repair thereof. Tenant understands that Landlord, in reliance upon Section 12.4, will not carry insurance of any kind on Tenant’s Property,
Tenant’s Alterations and leasehold improvements, and that Landlord shall not be obligated to repair any damage thereto or replace the same. 
 Section 13.3 Notwithstanding anything to the contrary contained in Sections 13.1 and 13.2 above, if the Premises shall be materially (i.e., thirty percent (30%) or more)
damaged or destroyed by fire or other casualty, or if a Building shall be so damaged or destroyed by fire or other casualty (whether or not the Premises are damaged or destroyed) that its repair or restoration requires the expenditure (as estimated
by a reputable contractor or architect designated by Landlord) of more than thirty percent (30%) of the full insurable value of a Building immediately prior to the casualty, then in either such case Landlord may, in Landlord’s sole and absolute
discretion, terminate this Lease (i) with respect to the entire Premises if more than thirty percent (30%) of the Premises are damaged, and (ii) with respect to that portion of the Premises that are located in any Building that is
materially damaged, but only to the extent that such portion of the Premises is located in the materially damaged Building(s), and the term and estate hereby granted, by notifying Tenant in writing of such termination within ninety (90) days
after the date of such damage. In the event that such a notice of termination shall be given, then this Lease and the term and estate hereby granted shall expire as of the date of termination stated in said notice with the same effect as if that
were the Fixed Expiration Date, and the Fixed Rent and Additional Rent payable pursuant to Articles 3 and 4 shall be apportioned as of such date. If the Premises shall be damaged or destroyed by fire or other casualty not caused by the

  
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negligence or wrongful act of Tenant, such that thirty percent (30%) or more of the Premises is rendered untenantable or reasonable means of access to the Premises is cut off and
(i) Landlord’s contractor or architect estimates that the Premises will not be substantially repaired or restored within one (1) year following such fire or other casualty, or (ii) the Premises are not substantially repaired and
restored within one (1) year after the date of the fire or other casualty, or (iii) because of Landlord’s failure to commence such repair and restoration within six (6) months after such casualty, such repair and restoration will
not be completed within such one (1) year period, then Tenant shall have the right to terminate this Lease by giving Landlord notice to such effect within thirty (30) days after the date of such fire or casualty, if pursuant to clause (i),
or the end of such six (6) month or one (1) year period, as the case may be, if pursuant to clause (ii) or (iii), in which event the Fixed Rent and Additional Rent shall be prorated and adjusted as of the date of termination.

 Section 13.4 Except as may be provided in Section 12.5, nothing herein contained shall relieve Tenant from
any liability to Landlord or to Landlord’s insurers in connection with any damage to the Premises or the Buildings by fire or other casualty if Tenant shall be legally liable in such respect. 

Section 13.5 This Lease shall be considered an express agreement governing any case of damage to or destruction of the Buildings or
any part thereof by fire or other casualty, and Section 227 of the Real Property Law of the State of New York providing for such a contingency in the absence of express agreement and any other law of like import now or hereafter in force, shall
have no application in such case. 
 ARTICLE 14 
 EMINENT DOMAIN 
 Section 14.1 If the whole of the Buildings or the
Premises is acquired or condemned for any public or quasi-public use or purpose, this Lease and the Term shall end as of the date of the vesting of title with the same effect as if said date were the Fixed Expiration Date. If only a part of a
Building, the Buildings or the Land and not the entire Premises is so acquired or condemned then, (1) except as hereinafter provided in this Section 14.1, this Lease and the Term shall continue in effect but, if a part of the
Premises is included in the part of a Building or the Land so acquired or condemned, from and after the date of the vesting of title, the Fixed Rent and the Additional Rent payable pursuant to Articles 3 and 4 shall be reduced in the
proportion which the area of the part of the Premises so acquired or condemned bears to the total area of the Premises immediately prior to such acquisition or condemnation; (2) provided that the Premises are affected thereby, Landlord, at
Landlord’s option, may give to Tenant, within sixty (60) days next following the date upon which Landlord receives notice of vesting of title, a thirty (30) day notice of termination of this Lease; and (3) if the part of a
Building, the Buildings or the Land so acquired or condemned contains more than twenty percent (20%) of the total area of the Premises immediately prior to such acquisition or condemnation and the remaining area of the Premises shall not be
reasonably sufficient for Tenant to continue feasible operation of its business, or if, by reason of such acquisition or condemnation, Tenant no longer has access to the Premises, Tenant, at Tenant’s option, may give to Landlord, within sixty
(60) days next following the date upon which Tenant receives notice of vesting of title, a thirty (30) day notice 

  
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of termination of this Lease. If any such thirty (30) day notice of termination is given, by Landlord or Tenant, this Lease and the Term shall come to an end and expire upon the expiration
of said thirty (30) days with the same effect as if the date of expiration of said thirty (30) days were the Fixed Expiration Date. If a part of the Premises is so acquired or condemned and this Lease and the Term are not terminated
pursuant to the foregoing provisions of this Section 14.1, Landlord, at Landlord’s cost and expense, shall restore that part of the Premises not so acquired or condemned to a self-contained rental unit, exclusive of Tenant’s
Alterations, leasehold improvements and Tenant’s Property. In the event of any termination of this Lease and the Term pursuant to the provisions of this Section 14.1, the Fixed Rent shall be apportioned as of the date of sooner
termination and any prepaid portion of the Fixed Rent or Additional Rent payable pursuant to Articles 3 and 4 for any period after such date shall be refunded by Landlord to Tenant. 

Section 14.2 In the event of any such acquisition or condemnation of all or any part of the Real Property, Landlord shall be
entitled to receive the entire award for any such acquisition or condemnation. Tenant shall have no claim against Landlord or the condemning authority for the value of any unexpired portion of the Term and Tenant hereby expressly assigns to Landlord
all of its right in and to any such award. Nothing contained in this Section 14.2 shall be deemed to prevent Tenant from making a separate claim in any condemnation proceedings for the value of any Tenant’s Property and
Tenant’s Alterations included in such taking, and for any moving expenses, so long as Landlord’s award is not reduced thereby. 
 Section 14.3 If the whole or any part of the Premises is acquired or condemned temporarily during the Term for any public or quasi-public use or purpose, the Term shall not be reduced or affected in
any way and Tenant shall continue to pay in full all items of Rental payable by Tenant hereunder without reduction or abatement, and Tenant shall be entitled to receive for itself any award or payments for such use; provided, however, that if
the acquisition or condemnation is for a period extending beyond the Term, such award or payment shall be apportioned between Landlord and Tenant as of the Expiration Date; provided, however, that the amount of any award or payment allowed or
retained for restoration of the Premises shall remain the property of Landlord if this Lease expires prior to the restoration of the Premises. 
 ARTICLE 15 
 ASSIGNMENT, SUBLETTING, MORTGAGE, ETC. 

Section 15.1 Tenant shall not, whether voluntarily, involuntarily, or by operation of law or otherwise (a) assign or otherwise
transfer this Lease other than to an Affiliate of Tenant, (b) sublet the Premises or any part thereof, or allow the same to be used, occupied or utilized by anyone other than Tenant, or (c) mortgage, pledge, encumber or otherwise
hypothecate this Lease or the Premises or any part thereof in any manner whatsoever, without in each instance obtaining the prior consent of Landlord. 
 Section 15.2 If and so long as Tenant is a corporation or a partnership, the following shall be deemed to be an assignment of this Lease under Section 15.1 prohibited by said Section
unless Tenant obtains the prior consent of Landlord: one or more sales or transfers of stock or partnership interests, voluntarily, involuntarily, by operation of law or otherwise, or the issuance

  
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of new stock or partnership interests, by which an aggregate of more than fifty percent (50%) of Tenant’s stock or partnership interests shall be vested in a party or parties who are
not stockholders or partners as of the date hereof. This Section shall not apply to transactions with a corporation, limited liability company or partnership into or with which Tenant is merged or consolidated or to which substantially all of
Tenant’s assets are transferred or to any corporation, limited liability company or partnership (an “Affiliate”) which controls Tenant or is controlled by Tenant or is under common control with Tenant if (a) the successor to
Tenant has a tangible net worth computed in accordance with generally accepted accounting principles at least equal to the greater of (i) the tangible net worth of Tenant immediately prior to such merger, consolidation or transfer, or (ii) the
tangible net worth on the date of this Lease of the original Tenant herein named, and (b) proof satisfactory to Landlord of such tangible net worth is delivered to Landlord at least ten (10) days prior to the effective date of any such
transaction. The provisions of this Section shall not apply to any corporation all the outstanding voting stock of which is listed on a national securities exchange (as defined in the Securities Exchange Act of 1934, as amended) or is traded in the
over-the-counter market with quotations reported by the National Association of Securities Dealers through its automated system for reporting quotations. The term “control” or “Control” as used in this Lease (i) in
the case of a corporation shall mean ownership of more than fifty percent (50%) of the outstanding voting common capital stock of that corporation, (ii) in the case of a general or limited liability partnership, shall mean more than fifty
percent (50%) of the general partnership or membership interest of the partnership, (iii) in the case of a limited partnership, shall mean more than fifty percent (50%) of the general partnership interests of such limited partnership, and
(iv) in the case of a limited liability company, shall mean more than fifty percent (50%) of the membership interests of such limited liability company. 
 Section 15.3 If this Lease is assigned, whether or not in violation of the provisions of this Lease, Landlord may collect rent from the assignee. If the Premises or any part thereof are sublet or
used or occupied by anybody other than Tenant, whether or not in violation of this Lease, Landlord may, after default by Tenant, and expiration of Tenant’s time to cure such default, collect rent from the subtenant or occupant. In either event,
Landlord may apply the net amount collected to the Fixed Rent and Additional Rent herein reserved, but no such assignment, subletting, occupancy or collection shall be deemed a waiver of any of the provisions of Section 15.1, or the
acceptance of the assignee, subtenant or occupant as tenant, or a release of Tenant from the performance by Tenant of Tenant’s obligations under this Lease. The consent by Landlord to assignment, mortgaging, subletting or use or occupancy by
others shall not in any way be considered to relieve Tenant from obtaining the consent of Landlord to any other or further assignment, mortgaging, subletting or use or occupancy by others not expressly permitted by this Article. References in this
Lease to use or occupancy by others (that is, anyone other than Tenant) shall not be construed as limited to subtenants and those claiming under or through subtenants but as including also licensees and others claiming under or through Tenant,
immediately or remotely. 
 Section 15.4 Any assignment or transfer, whether made with Landlord’s consent pursuant to
Section 15.1 or without the requirement of Landlord’s consent pursuant to Section 15.2, shall be made only if, and shall not be effective until, the assignee shall execute, acknowledge and deliver to Landlord an
agreement in form and substance reasonably satisfactory to Landlord whereby the assignee shall assume the obligations of this Lease on the part of Tenant to be performed or observed and whereby the assignee shall agree that the

  
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provisions in Section 15.1 shall, notwithstanding such assignment or transfer, continue to be binding upon it in respect of all future assignments and transfers. Notwithstanding any
assignment or transfer, whether or not in violation of the provisions of this Lease, and notwithstanding the acceptance of the Fixed Rent or Additional Rent by Landlord from an assignee, transferee, or any other party, the original named Tenant
shall remain fully liable for the payment of the Fixed Rent and Additional Rent and for the other obligations of this Lease on the part of Tenant to be performed or observed. 
 Section 15.5 The liability of Tenant and any immediate or remote successor in interest of Tenant and the due performance of the obligations of this Lease on Tenant’s part to be performed or
observed shall not be discharged, released or impaired in any respect by any agreement or stipulation made by Landlord with the then Tenant extending the time of, or modifying any of the obligations of, this Lease, or by any waiver or failure of
Landlord to enforce any of the obligations of this Lease. 
 Section 15.6 Neither the listing of any name other than that
of Tenant, whether on the door of the Premises or on any directory, or otherwise, nor the acceptance by Landlord of any check not drawn by Tenant in payment of Fixed Rent or Additional Charges, shall operate to vest any right or interest in this
Lease or in the Premises, nor shall it be deemed to be the consent of Landlord to any assignment or transfer of this Lease or to any sublease of the Premises or to the use or occupancy thereof by others. 

Section 15.7 Except as specifically provided to the contrary in this Article 15, if Tenant shall at any time or times during
the Term desire to assign this Lease or sublet all or any part of the Premises, Tenant shall give notice thereof to Landlord, which notice shall be accompanied by (a) a reasonably detailed term sheet conformed or photostatic copy of the
proposed assignment or sublease, the effective or commencement date of which shall be at least thirty (30) days after the giving of such notice, (b) a statement setting forth in reasonable detail the identity of the proposed assignee or
subtenant, the nature of its business and its proposed use of the Premises, and (c) current financial information with respect to the proposed assignee or subtenant, including, without limitation, its most recent financial report. Such notice
shall be deemed an offer from Tenant to Landlord whereby Landlord (or Landlord’s designee) may, at its option, terminate this Lease with respect to the portion of the Premises proposed to be sublet or assigned. Said option may be exercised by
Landlord by notice to Tenant at any time within thirty (30) days after such notice has been given by Tenant to Landlord; and during such thirty (30)-day period Tenant shall not assign this Lease or sublet such space to any person. 

Section 15.8 Intentionally omitted. 
 Section 15.9 Intentionally omitted. 
 Section 15.10 If Landlord does not
exercise its option to terminate the proposed sublease or assigned portion of the Premises pursuant to Section 15.7. and provided that Tenant is not in default of any of Tenant’s obligations under this Lease, Landlord’s consent
(which shall be in form reasonably satisfactory to Landlord) to the proposed assignment or sublease shall not be unreasonably withheld or delayed, provided and upon condition that: 

(A) Tenant shall have complied with the provisions of Section 15.7; 

  
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 (B) in Landlord’s judgment the proposed assignee or subtenant is engaged in a business
and the Premises will be used in a manner which (i) is in keeping with the then standards of the Buildings, (ii) is limited to the use expressly permitted under Section 5.1, or any other office, laboratory or similar use which
complies with Legal Requirements and Insurance Requirements and otherwise with the provisions of this Lease, and (iii) will not violate any negative covenant as to use contained in any other lease of space in the Project; 

(C) the proposed assignee or subtenant is a reputable person of good character and with sufficient financial worth considering the
responsibility involved, and Landlord has been furnished with reasonable proof thereof; 
 (D) the proposed assignee or
sublessee is not a person with whom Landlord is then negotiating or in the prior three (3)-month period was negotiating to lease space in the Project; 
 (E) Tenant shall deliver to Landlord a copy of the proposed Sublease, which shall be in a form reasonably satisfactory to Landlord and shall comply with the applicable provisions of this Article; and

 (F) the consent of any Mortgagee whose Mortgage requires the consent of the Mortgagee shall have been obtained. 

Section 15.11 Tenant shall reimburse Landlord on demand for any reasonable costs that may be incurred by Landlord in connection with
any proposed assignment or sublease, whether consented to by Landlord or not, including, without limitation, the costs of making investigations as to the acceptability of the proposed assignee or subtenant, and legal costs incurred in connection
with the granting of any requested consent. 
 Section 15.12 The amount of the aggregate rent per rentable square foot to
be paid by a proposed subtenant under a proposed sublease shall not be less than the then-current Rental per rentable square foot for the Premises set forth herein, unless the proposed sublease or assignment shall provide that, in the event that the
assignee or subtenant attorns to Landlord, then, immediately upon such attornment, the rental rate for the subleased or assigned premises shall increase to a rental rate equal to the then-current Rental as set forth herein. The rental and other
terms and conditions of any actual sublease shall be the same as those contained in the proposed sublease term sheet furnished to Landlord pursuant to Section 15.7. 

Section 15.13 Except for any subletting by Tenant to Landlord or its designee pursuant to the provisions of this Article, each
subletting pursuant to this Article shall be subject to all of the covenants, agreements, terms, provisions and conditions contained in this Lease. Notwithstanding any such subletting to Landlord or any such subletting to any other subtenant and/or
acceptance of rent or additional rent by Landlord from any subtenant, Tenant shall and will remain fully liable for the payment of the Fixed Rent and Additional Rent due and to become due hereunder and for the performance of all the covenants,
agreements, terms, provisions and conditions contained in this Lease on the part of Tenant to be performed and all acts and omissions of any licensee or subtenant or anyone claiming under or through any subtenant which shall be in violation of any
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any such subletting, no other and further subletting of the Premises by Tenant or any person claiming through or under Tenant shall or will be made except upon compliance with and subject to the
provisions of this Article. Whether or not Landlord declines to give its consent to any proposed assignment or sublease, or if Landlord shall exercise its option to terminate under Section 15.7, Tenant shall indemnify, defend and hold
harmless Landlord against and from any and all loss, liability, damages, costs and expenses (including reasonable counsel fees) resulting from any claims that may be made against Landlord by the proposed assignee or sublessee or by any brokers or
any other persons claiming a commission or similar compensation in connection with the proposed assignment or sublease. 

Section 15.14 If (a) Landlord fails to exercise its option to terminate under Section 15.7 and Landlord consents to
a proposed assignment or sublease, and (b) Tenant fails to execute and deliver the assignment or sublease to which Landlord consented within ninety (90) days after the giving of such consent, then Tenant shall again comply with all of the
provisions and conditions of Section 15.7 before assigning this Lease or subletting all or any part of the Premises. 
 Section 15.15 With respect to each and every sublease or subletting authorized by Landlord under the provisions of this Lease, it is further agreed that: 

(A) no subletting shall be for a term ending later than one (1) day prior to the expiration date of this Lease; 

(B) no sublease shall be valid, and no subtenant shall take possession of the Premises or any part thereof, until an executed counterpart
of such sublease has been delivered to Landlord; and 
 (C) each sublease shall provide that it is subject and subordinate to
this Lease and to the matters to which this Lease is or shall be subordinate, and that in the event of termination, reentry or dispossess by Landlord under this Lease Landlord may, at its option, take over all of the right, title and interest of
Tenant, as sublessor, under such sublease, and such subtenant shall, at Landlord’s option, attorn to Landlord pursuant to the then executory provisions of such sublease, except that Landlord shall not (i) be liable for any previous act or
omission of Tenant under such sublease, (ii) be subject to any offset which theretofore accrued to such subtenant against Tenant, or (iii) be bound by any previous modification of such sublease or by any previous prepayment of more than
one (1) month’s rent. 
 (D) If (i) a subtenant of Tenant, under a sublease for which Landlord’s consent is
required hereunder and has been obtained, has a minimum net worth calculated in accordance with generally accepted accounting principles equal to at least six times the aggregate of the annual fixed rent, operating payments and tax payments provided
for in such sublease (ii) such sublease (A) has a term of five (5) years or more, (B) provides for the demise of at least fifty percent (50%) of the rentable area of the Premises and (C) provides on a per rentable
square foot basis for a fixed rental and additional rent equal to or greater than the Fixed Rent and Additional Charges provided for in this Lease (or which provides for the escalation of such subtenant’s rental to such level at such time as it
seeks to invoke the protections of this Section), and (iii) Landlord shall be reimbursed for its reasonable out-of-pocket costs in connection therewith (including, without limitation, reasonable legal fees), then Landlord shall execute and
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such subtenant, at the time such sublease is made, a non-disturbance agreement in form reasonably satisfactory to Landlord, confirming Landlord’s agreement hereunder to recognize such
subtenant as the direct tenant of Landlord upon the termination of this Lease by reason of a default by Tenant, provided that at the time of the termination of this Lease (x) no default exists under the subtenant’s sublease which would
then permit the landlord thereunder to terminate the sublease or to exercise any dispossess remedy provided for therein and (y) the subtenant will deliver to Landlord an instrument confirming the agreement of the subtenant to attorn to Landlord
and to recognize Landlord as such subtenant’s landlord under the sublease, which instrument shall provide that neither Landlord nor anyone claiming by, through or under Landlord, shall be: 

(1) liable for any act or omission of any prior landlord (including the then-defaulting landlord), 

(2) subject to any offsets or defenses which the subtenant may have against any prior landlord (including the then-defaulting landlord),

 (3) bound by any payment of rent which the subtenant might have made for more than one (1) month in advance of the due
date of any corresponding rental obligation under this Lease to any prior landlord (including the then-defaulting landlord), 

(4) liable for any security deposited by such subtenant which has not been transferred as such to Landlord, 

(5) bound by any covenant to undertake or complete any construction of the premises demised by said sublease, 

(6) bound by any obligation to make any payment to the subtenant, except for services, repairs, maintenance and restoration provided for
under the sublease to be performed after the date of such termination of this Lease to the extent Landlord would be obligated to perform the same under this Lease, or 
 (7) bound by any modification of the sublease to which Landlord shall have not consented in writing. 
 ARTICLE 16 
 ACCESS TO PREMISES 

Section 16.1 (A) Tenant shall permit Landlord, Landlord’s agents and public utilities servicing the Buildings to erect,
use and maintain concealed ducts, pipes and conduits in and through the Premises. Landlord or Landlord’s agents shall have the right to enter the Premises at all reasonable times upon (except in case of emergency) reasonable prior notice, which
notice may be oral, to examine the same, to perform audits or inspections for Hazardous Materials, to show the same to prospective purchasers, Mortgagees or lessees of the Buildings or space therein, or to make such repairs, alterations,
improvements or additions (i) as Landlord may deem necessary or desirable to the Premises or to any other portion of the Buildings, or (ii) which Landlord may elect to perform at least ten (10) days after notice (except in an

  
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emergency when no notice shall be required) following Tenant’s failure to make repairs or perform any work which Tenant is obligated to make or perform under this Lease, or (iii) for
the purpose of complying with Requirements, and Landlord shall be allowed to take all material into and upon the Premises that may be required therefor without the same constituting an eviction or constructive eviction of Tenant in whole or in part
and the Fixed Rent (and any other item of Rental) shall in no respect abate or be reduced by reason of said repairs, alterations, improvements or additions, wherever located, or while the same are being made, by reason of loss or interruption of
business of Tenant, or otherwise. Landlord shall promptly repair any damage caused to the Premises by such work, alterations, improvements or additions. Landlord shall not store materials in the Premises (except during performance of the work),
unless they are confined to the area in which such alterations, additions and improvements are being performed. In exercising its rights under this Section 16.1, Landlord shall attempt to coordinate with Tenant in making any repairs,
alterations or improvements in the Premises and shall use reasonable efforts to minimize interference with Tenant’s conduct of business in the Premises, provided Landlord shall not be required to use overtime labor. 

(B) Any work performed or installations made pursuant to this Article 16 shall be made with reasonable diligence and otherwise
pursuant to Section 7.3. 
 (C) Any pipes, ducts, or conduits installed in or through the Premises pursuant to this
Article 16 shall, if reasonably practicable, either be concealed behind, beneath or within partitioning, columns, ceilings or floors located or to be located in the Premises, or completely furred at points immediately adjacent to
partitioning, columns or ceilings located or to be located in the Premises. 
 Section 16.2 If Tenant is not present when
for any reason entry into the Premises may be necessary or permissible, Landlord or Landlord’s agents may enter the same without rendering Landlord or such agents liable therefor (if during such entry Landlord or Landlord’s agents accord
reasonable care to Tenant’s Property), and without in any manner affecting this Lease. 
 Section 16.3 Landlord also
shall have the right at any time, without the same constituting an actual or constructive eviction and without incurring any liability to Tenant therefor, to change the arrangement or location of entrances or passageways, doors and doorways, and
corridors, elevators, stairs, toilets or other public parts of the Buildings, provided any such change does not unreasonably interfere with, or deprive Tenant of access to, the Buildings or the Premises; to put so-called “solar film” or
other energy-saving installations on the inside and outside of the windows; and to change the name, number or designation by which the Buildings and/or the Project are commonly known. All parts (except surfaces facing the interior of the Premises)
of all walls, windows and doors bounding the Premises (including exterior Building walls, exterior core corridor walls, exterior doors and entrances), all space in or adjacent to the Premises used for shafts, stacks, stairways, chutes, pipes,
conduits, ducts, fan rooms, heating, air cooling, plumbing and other mechanical facilities, service closets and other Building facilities are not part of the Premises, and Landlord shall have the use thereof, as well as access thereto through the
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 ARTICLE 17 
 CERTIFICATE OF OCCUPANCY 
 Section 17.1 Tenant shall not at any time
use or occupy the Premises in violation of the certificate of occupancy at such time issued for the Premises or for a Building. Without limiting the generality of the foregoing, if the certificate of occupancy for the Premises or a Building limits
the total number of persons permitted to occupy the floor of a Building on which the Premises is located, then Tenant shall be entitled to use the Premises to accommodate a proportionate share of the total number of persons permitted by the
certificate of occupancy to occupy the floor of a Building on which the Premises is located, based upon the ratio that the rentable square footage of the Premises bears to the total rentable square footage on such floor of a Building. In the event
that any Government Authority hereafter contends or declares by notice, violation, order or in any other manner whatsoever that the Premises are used for a purpose that is a violation of such certificate of occupancy, Tenant shall, upon three
(3) Business Days’ written notice from Landlord or any Government Authority, immediately discontinue such use of the Premises; provided, however, that nothing herein shall prevent Tenant from contesting such violation pursuant to
and in accordance with the provisions of Section 9.5. 
 ARTICLE 18 

DEFAULT 

Section 18.1 Each of the following events shall be an “Event of Default” under this Lease: 

(A) if Tenant shall on any occasion default in the payment when due of any installment of Fixed Rent or in the payment when due of any
other item of Rental and such default shall continue for five (5) Business Days after Landlord shall have given Tenant written notice of such default; or 
 (B) if Tenant shall fail more than three (3) times in any period of twelve consecutive months to make a payment when due of any Rental, and Landlord shall have given Tenant notice of such default
after three such occurrences; or 
 (C) omitted; or 
 (D) if the Premises shall become vacant or abandoned; or 
 (E) if Tenant’s
interest in this Lease shall devolve upon or pass to any person, whether by operation of law or otherwise, except as expressly permitted under Article 15 hereof; or 
 (F) (1) if Tenant shall not, or shall be unable to, or shall admit in writing Tenant’s inability to, as to any obligation, pay Tenant’s debts as they become due; or 

(2) if Tenant shall commence or institute any case, proceeding or other action (a) seeking relief on Tenant’s behalf as
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or seeking reorganization, arrangement, adjustment, winding-up, liquidation, dissolution, composition or other relief with respect to Tenant or Tenant’s debts under any existing or future
law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency, reorganization or relief of debtors, or (b) seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or any substantial
part of its property; or 
 (3) if Tenant shall make a general assignment for the benefit of creditors; or 

(4) if any case, proceeding or other action shall be commenced or instituted against Tenant (a) seeking to have an order for relief
entered against Tenant as debtor or to adjudicate Tenant a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment, winding-up, liquidation, dissolution, composition or other relief with respect to Tenant or Tenant’s debts
under any existing or future law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency, reorganization or relief of debtors, or (b) seeking appointment of a receiver, trustee, custodian or other similar official for
Tenant or for all or any substantial part of Tenant’s property, which either (i) results in any such entry of an order for relief; adjudication of bankruptcy or insolvency or such an appointment or the issuance or entry of any other order
having a similar effect or (ii) remains undismissed for a period of ninety (90) days; or 
 (5) if any case,
proceeding or other action shall be commenced or instituted against Tenant seeking issuance of a warrant of attachment, execution, distraint or similar process against all or any substantial part of Tenant’s property which results in the entry
of an order for any such relief which is not vacated, discharged, stayed or bonded pending appeal within ninety (90) days from the entry thereof; or 
 (6) if Tenant shall take any action in furtherance of, or indicating Tenant’s consent to, approval of, or acquiescence in, any of the acts set forth in clauses (2), (3), (4) or (5) above;
or 
 (7) if a trustee, receiver or other custodian shall be appointed for any substantial part of the assets of Tenant which
appointment is not vacated or effectively stayed within ninety (90) days; or 
 (G) if Tenant shall default in the
observance or performance of any other term, covenant or condition of this Lease on Tenant’s part to be observed or performed and Tenant shall fail to remedy such default within thirty (30) days after notice by Landlord to Tenant of such
default, or if such default is of such a nature that it cannot with due diligence be completely remedied within said period of thirty (30) days and the continuation of which for the period required for cure will not subject Landlord to the risk
of criminal liability or termination of any Superior Lease or foreclosure of any Mortgage, if Tenant shall not, (i) within said thirty (30)-day period advise Landlord of Tenant’s intention duly to institute all steps necessary to remedy
such situation, (ii) duly institute within said thirty (30)-day period, and thereafter diligently and continuously prosecute to completion all steps necessary to remedy the same and (iii) complete such remedy within such time after the
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 Section 18.2 If an Event of Default shall occur, Landlord may, at any time thereafter,
at Landlord’s option, give written notice to Tenant stating that this Lease and the Term shall expire and terminate on the date specified in such notice, which date shall not be less than three (3) days after the giving of such notice,
whereupon this Lease and the Term and all rights of Tenant under this Lease shall automatically expire and terminate as if the date specified in the notice given pursuant to this Section 18.2 were the Fixed Expiration Date and Tenant
immediately shall quit and surrender the Premises, but Tenant shall remain liable for damages as provided herein or pursuant to law. Anything contained herein to the contrary notwithstanding, if such termination shall be stayed by order of any court
having jurisdiction over any proceeding described in Section 18.1(F), or by federal or state statute, then, following the expiration of any such stay, or if the trustee appointed in any such proceeding, Tenant or Tenant as
debtor-in-possession fails to assume Tenant’s obligations under this Lease within the period prescribed therefor by law or within one hundred twenty (120) days after entry of the order for relief or as may be allowed by the court, or if
said trustee, Tenant or Tenant as debtor-in-possession shall fail to provide adequate protection of Landlord’s right, title and interest in and to the Premises or adequate assurance of the complete and continuous future performance of
Tenant’s obligations under this Lease, Landlord, to the extent permitted by law or by leave of the court having jurisdiction over such proceeding, shall have the right, at its election, to terminate this Lease on three (3) days’
notice to Tenant, Tenant as debtor-in-possession or said trustee and upon the expiration of said three (3)-day period this Lease shall cease and expire as aforesaid and Tenant, Tenant as debtor-in-possession or said trustee shall immediately quit
and surrender the Premises as aforesaid. 
 Section 18.3 If, at any time, (i) Tenant shall consist of two (2) or
more persons, or (ii) Tenant’s obligations under this Lease shall have been guaranteed by any person other than Tenant, or (iii) Tenant’s interest in this Lease has been assigned, the word “Tenant” as used in
Section 18.1(F), shall be deemed to mean any one or more of the persons primarily or secondarily liable for Tenant’s obligations under this Lease. Any monies received by Landlord from or on behalf of Tenant during the pendency of
any proceeding of the types referred to in Section 18.1(F) shall be deemed paid as compensation for the use and occupancy of the Premises and the acceptance of any such compensation by Landlord shall not be deemed an acceptance of Rental
or a waiver on the part of Landlord of any rights under Section 18.2. 
 ARTICLE 19 

REMEDIES AND DAMAGES 
 Section 19.1 (A) If any Event of Default shall occur, or this Lease and the Term shall expire and come to an end as provided in Article 18: 

(1) Tenant shall quit and peacefully surrender the Premises to Landlord, and Landlord and its agents may immediately, or at any time
after such Event of Default or after the date upon which this Lease and the Term shall expire and come to an end, re-enter the Premises or any part thereof, without notice, either by summary proceedings, or by any other applicable action or
proceeding, or by force or otherwise (without being liable to indictment, prosecution or damages therefor), and may repossess the Premises and dispossess Tenant and any other persons from the Premises by summary proceedings or otherwise and remove
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 (2) Landlord, at Landlord’s option, may relet the whole or any part or parts of the
Premises from time to time, either in the name of Landlord or otherwise, to such tenant or tenants, for such term or terms ending before, on or after the Fixed Expiration Date, at such rent or rentals and upon such other conditions, which may
include concessions and free rent periods, as Landlord, in Landlord’s sole discretion, may determine; provided, however, that Landlord shall have no obligation to relet the Premises or any part thereof and shall in no event be liable for
refusal or failure to relet the Premises or any part thereof, or, in the event of any such reletting, for refusal or failure to collect any rent due upon any such reletting, and no such refusal or failure shall operate to relieve Tenant of any
liability under this Lease or otherwise affect any such liability, and Landlord, at Landlord’s option, may make such Alterations, in and to the Premises as Landlord, in Landlord’s sole discretion, shall consider advisable or necessary in
connection with any such reletting or proposed reletting, without relieving Tenant of any liability under this Lease or otherwise affecting any such liability. 
 (B) Tenant hereby waives the service of any notice of intention to re-enter or to institute legal proceedings to that end that may otherwise be required to be given under any present or future law.
Tenant, on its own behalf and on behalf of all persons claiming through or under Tenant, including all creditors, does further hereby waive any and all rights that Tenant and all such persons might otherwise have under any present or future law to
redeem the Premises, or to re-enter or repossess the Premises, or to restore the operation of this Lease, after (a) Tenant shall have been dispossessed by a judgment or by warrant of any court or judge, or (b) any re-entry by Landlord, or
(c) any expiration or termination of this Lease and the Term, whether such dispossess, re-entry, expiration or termination is by operation of law or pursuant to the provisions of this Lease. The words “re-entry”, “re-enter”
and “re-entered” as used in this Lease shall not be deemed to be restricted to their technical legal meanings. In the event of a breach or threatened breach by Tenant, or any persons claiming through or under Tenant, of any term, covenant
or condition of this Lease, Landlord shall have the right to enjoin such breach and the right to invoke any other remedy allowed by law or in equity as if re-entry, summary proceedings and other special remedies were not provided in this Lease for
such breach. The right to invoke the remedies hereinbefore set forth are cumulative and shall not preclude Landlord from invoking any other remedy allowed at law or in equity. 
 Section 19.2 (A) If this Lease and the Term shall expire and come to an end as provided in Article 18, or by or under any summary proceeding or any other action or proceeding, or if
Landlord shall re-enter the Premises as provided in Section 19.1, or by or under any summary proceeding or any other action or proceeding, then, in any of said events: 

(1) Tenant shall pay to Landlord all Fixed Rent, all Additional Rent (including Additional Rent payable pursuant to Articles 3 and
4) and other items of Rental payable under this Lease by Tenant to Landlord to the date upon which this Lease and the Term shall have expired and come to an end or to the date of re-entry upon the Premises by Landlord, as the case may be;

 (2) Tenant also shall be liable for and shall pay to Landlord, as damages, any deficiency (“Deficiency”)
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would have constituted the unexpired portion of the Term and the net amount, if any, of rents collected under any reletting effected pursuant to the provisions of Section 19.1 (A)(2)
for any part of such period (after first deducting from the rents collected under any such reletting all of Landlord’s expenses in connection with the termination of this Lease, Landlord’s reentry upon the Premises and such reletting
including, but not limited to, all repossession costs, brokerage commissions, attorneys’ fees and disbursements, alteration costs and other expenses of preparing the Premises for such reletting); any such Deficiency shall be paid in monthly
installments by Tenant on the days specified in this Lease for payment of installments of Fixed Rent; Landlord shall be entitled to recover from Tenant each monthly Deficiency as the same shall arise, and no suit to collect the amount of the
Deficiency for any month shall prejudice Landlord’s right to collect the Deficiency for any subsequent month by a similar proceeding; and 
 (3) whether or not Landlord shall have collected any monthly Deficiency as aforesaid, Landlord shall be entitled to recover from Tenant, and Tenant shall pay to Landlord, on demand, in lieu of any further
Deficiency as and for liquidated and agreed final damages, a sum equal to the amount by which the unpaid Rental for the period which otherwise would have constituted the unexpired portion of the Term exceeds the then fair and reasonable rental value
of the Premises for the same period, both discounted to present worth at four percent (4%) per annum less than the Base Rate; if, before presentation of proof of such liquidated damages to any court, commission or tribunal, the Premises, or any
part thereof, are relet by Landlord for the period which otherwise would have constituted the unexpired portion of the Term, or any part thereof, the amount of rent reserved upon such reletting shall be deemed, prima facie, to be the
fair and reasonable rental value for the part or the whole of the Premises so relet during the term of the reletting. 
 (B) If
the Premises, or any part thereof, shall be relet together with other space in a Building, the rents collected or reserved under any such reletting and the expenses of any such reletting shall be equitably apportioned for the purposes of this
Section 19.2. Tenant shall in no event be entitled to any rents collected or payable under any reletting (except as a credit against amounts owing to Landlord as set forth above), whether or not such rents exceed the Fixed Rent reserved
in this Lease. Solely for the purposes of this Article 19, the phrase “Additional Rent payable pursuant to Articles 3 and 4” as used in Section 19.2(A) shall mean the Additional Rent payable pursuant to
Articles 3 and 4 in effect immediately prior to the Expiration Date, or the date of re-entry upon the Premises by Landlord, as the case may be. Nothing contained in Article 18 or this Article 19 shall be deemed to limit or
preclude the recovery by Landlord from Tenant of the maximum amount allowed to be obtained as damages by any statute or rule of law, or of any sums or damages to which Landlord may be entitled in addition to the damages set forth in this
Section 19.2. 
 ARTICLE 20 
 FEES AND EXPENSES 
 Section 20.1 If (i) Tenant shall default
under this Lease, or (ii) Tenant does or permits any act or thing upon the Premises, not expressly permitted under this Lease, that would cause Landlord to be in default under any Superior Lease or Mortgage and Tenant does not cure such act or
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pursuant to any Superior Lease or Mortgage) after notice thereof (or without notice in case of emergency), or (iii) Tenant fails to comply with its obligations under this Lease and the
preservation of property or the safety of any tenant, occupant or other person is threatened, Landlord may (1) perform the same for the account of Tenant (but shall not be obligated to do so), or (2) make any expenditure or incur any
obligation for the payment of money in connection with any obligation owed to Landlord, including, but not limited to, reasonable attorneys’ fees and disbursements in instituting, prosecuting or defending any action or proceeding, and in either
case the cost thereof, with interest thereon at the Applicable Rate, shall be deemed to be Additional Rent hereunder and shall be paid by Tenant to Landlord within ten (10) days after rendition of any bill or statement to Tenant therefor. In
addition, Tenant shall pay Landlord any reasonable attorneys’ fees and disbursements incurred by Landlord in connection with any proceeding in which the value for the use and occupancy of the Premises by Tenant is being determined (but only if
such proceeding results from a default by Tenant under this Lease). In the proof of any losses that Landlord may claim against Tenant arising out of Tenant’s failure to maintain insurance, Landlord will not be limited to the amount of the
unpaid insurance premium but rather Landlord will also be entitled to recover the amount of any uninsured loss (to the extent of any deficiency in the insurance required by the provisions of this Lease), damages, costs, and expenses of lawsuit
(including attorney’s fees) arising out of damage or destruction occurring during any period for which Tenant has failed to adequately provide such insurance as required. Any reservation of a right by Landlord to enter upon the Premises and to
make or perform any repairs, Alterations, or other work in, to or about the Premises, which, in the first instance, is Tenant’s obligation pursuant to this Lease, shall not be deemed to: (x) impose any obligation on Landlord to do so,
(y) render Landlord liable to Tenant or any third party for the failure to do so, or (z) relieve Tenant from any obligation to indemnify Landlord as otherwise provided elsewhere in the Lease. 

Section 20.2 If Tenant shall fail to pay any installment of Fixed Rent, Additional Rent or any other item of Rental when due,
(i) Tenant shall pay to Landlord, as Additional Rent, on or before the first day of the following month three and one-half ($.035) cents for each dollar so overdue (but in no event greater than the maximum interest rate permitted by law) in
order to defray Landlord’s administrative and other costs in connection with such late payment and (ii) Tenant shall pay to Landlord, in addition to such installment of Fixed Rent, Additional Rent or other item of Rental, as the case may
be, and in addition to the foregoing late charge, and as Additional Rent, a sum equal to interest at the Applicable Rate on the amount unpaid, computed from the date such payment was due to and including the date of payment. 

ARTICLE 21 

NO REPRESENTATIONS BY LANDLORD 
 Section 21.1 Landlord and Landlord’s agents have made no representations, warranties or promises with respect to the Buildings, the Real Property or the Premises except as herein expressly set
forth, and no rights, easements or licenses are acquired by Tenant by implication or otherwise except as expressly set forth herein. Tenant acknowledges that (a) it is in possession of the 769 Premises and a portion of 771 Premises and is fully
familiar with the condition of the Premises and Tenant shall, subject to the completion of the Landlord Improvements, accept possession of the Premises in its “as is” condition on the Commencement Date, and (b) Landlord

  
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shall have no other obligation to perform any work or make any installations in order to prepare the Premises for Tenant’s occupancy, except for the Landlord Improvements. The taking of
occupancy of the whole or any part of the Premises by Tenant shall be conclusive evidence, as against Tenant, that Tenant accepts possession of the same and that the Premises and the Buildings were in good and satisfactory condition (excluding
latent defects) at the time such occupancy was so taken and that the Premises were substantially as shown on Schedule A. All references in this Lease to the consent or approval of Landlord shall be deemed to mean the written consent or
approval executed by Landlord and no other consent or approval of Landlord shall be effective for any purpose whatsoever. 

ARTICLE 22 

END OF TERM 
 Section 22.1 Upon the expiration or other termination of this Lease, Tenant shall quit and surrender to Landlord the Premises, vacant, broom clean, in good order and condition, ordinary wear and tear
excepted, and Tenant shall remove all of Tenant’s Alterations, as may be required pursuant to Article 6. Tenant shall also remove all of Tenant’s Property and all other personal property and personal effects of all persons claiming
through or under Tenant, and shall pay the cost of repairing all damage to the Premises and the Real Property occasioned by such removal. Any Tenant’s Property or other personal property that remains in the Premises after the termination of
this Lease shall be deemed to have been abandoned and either may be retained by Landlord as its property or may be disposed of in such manner as Landlord may see fit. If such Tenant’s Property or other personal property or any part thereof is
sold, Landlord may receive and retain the proceeds of such sale as the property of Landlord. Any expense incurred by Landlord in removing or disposing of such Tenant’s Property or other personal property or Alterations required to be removed as
provided in Article 6, as well as the cost of repairing all damage to the Buildings or the Premises caused by such removal, shall be reimbursed to Landlord by Tenant, as Additional Rent, on demand. 

Section 22.2 If the Expiration Date falls on a day which is not a Business Day, then Tenant’s obligations under
Section 22.1 shall be performed on or prior to the immediately preceding Business Day. 
 Section 22.3 Tenant
expressly waives, for itself and for any person claiming through or under Tenant, any rights that Tenant or any such person may have under the provisions of Section 2201 of the New York Civil Practice Law and Rules and of any similar or
successor law of like import then in force in connection with any holdover proceedings that Landlord may institute to enforce the provisions of this Article. 
 Section 22.4 If the Premises are not surrendered upon the expiration or other termination of this Lease, Tenant hereby indemnifies Landlord against liability or expense (including any consequential
damages) resulting from delay by Tenant in so surrendering the Premises, including any claims made by any succeeding tenant or prospective tenant founded upon such delay and agrees to be liable to Landlord for (i) any payment or rent concession
which Landlord may be required to make to any tenant obtained by Landlord for all or any part of the Premises in order to induce such tenant not to terminate its lease by reason of the holding-over by Tenant and (ii) the loss of the benefit of the
bargain if any such tenant shall terminate its lease by reason of the holding-over by Tenant. 

  
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 Section 22.5 Tenant’s obligation under this Article shall survive the expiration
or termination of this Lease. 
 ARTICLE 23 
 POSSESSION AND TENANT IMPROVEMENTS 
 Section 23.1 If Landlord shall be
unable to deliver possession of the 777 Premises or any additional space to be included within the Premises on the specific date (if any) designated in this Lease for the commencement of the Term or for the inclusion of such space for any reason
whatsoever, Landlord shall not be subject to any liability therefor and the validity of this Lease shall not be impaired thereby, but the 777 Premises Commencement Date shall be postponed until three (3) Business Days after notice from Landlord
that the Premises or such additional space are available for occupancy by Tenant. Tenant expressly waives any other right to rescind this Lease under Section 223-a of the New York Real Property Law or under any present or future statute of
similar import then in force and further expressly waives the right to recover any damages that may result from Landlord’s failure to deliver possession of the Premises or such additional space on the specific date (if any) designated for the
commencement of the Term. Tenant agrees that the provisions of this Article 23 are intended to constitute “an express provision to the contrary” within the meaning of said Section 223-a. Tenant expressly acknowledges that the
777 Premises are currently occupied by third-party occupants and that the 777 Premises Commencement Date is conditioned upon the execution and delivery of any and all documentation necessary to terminate any lease or agreement with respect to such
third-party occupants of any portion of the 777 Premises. 
 Section 23.2 Tenant shall execute and deliver to Landlord
written acknowledgment of the actual 777 Premises Commencement Date within ten (10) days after Tenant takes occupancy of the Premises. Failure to execute and deliver such acknowledgment, however, shall not affect the 777 Premises Commencement
Date or Landlord’s or Tenant’s liability hereunder. Failure by Tenant to obtain validation by any medical review board or other similar governmental licensing of the Premises, if and to the extent required for the Permitted Use by Tenant
shall not serve to extend the 777 Premises Commencement Date. 
 Section 23.3 Tenant shall cause to be constructed the
tenant improvements, including signage and 771 Building signage, in and about the Premises (the “Tenant Improvements”) consistent with the Permitted Use at a cost to Landlord not to exceed One Million One Hundred Fifty-Seven
Thousand Nine Hundred Dollars ($1,157,900) (based upon Ten Dollars ($10.00) per rentable square foot of the 769 Premises and 771 Premises) (the “TI Allowance”). The Tenant Improvements shall be constructed by Tenant in accordance
with the procedures for Alterations set forth Article 6 hereof. The TI Allowance may be applied to the costs of (a) construction, (b) project review by Landlord (in accordance with Section 6.2), (c) space planning,
architect, engineering and other related services performed by third parties unaffiliated with Tenant, (d) building permits and other taxes, fees, charges and levies by Governmental Authorities (as defined below) for permits or for inspections
of the Tenant Improvements, (e) costs and expenses 

  
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for labor, material, equipment and fixtures, and (f) furniture, fixtures and equipment to be placed within the Premises in an amount not to exceed Two Hundred Eighty-Nine Thousand Four Hundred
Seventy-Five Dollars ($289,475) (based on twenty-five percent (25%) of the TI Allowance). In no event shall the TI Allowance be used for (v) the cost of work that is not authorized by the approval in writing by Landlord in accordance with Article
6, (w) payments to Tenant or any affiliates of Tenant, except for the Rental credit, if any, due to Tenant pursuant to Section 23.4 below, (x) the purchase of any furniture, personal property or other non-building system equipment
exceeding twenty-five percent (25%) of the TI Allowance, (y) costs resulting from any default by Tenant of its obligations under this Lease or (z) costs that are recovered by Tenant from a third party (e.g., insurers, warrantors, or tortfeasors);
provided that Tenant shall use commercially reasonable efforts short of litigation to recover any such costs. The TI Allowance may be allocated by Tenant to any floor or portion of the Premises with no requirement to expend any minimum amount
or maximum amount on any floor or portion of the Premises. 
 Section 23.4 Tenant may request payment of the TI Allowance
in installments as costs are incurred, not more frequently than once per month, upon submission to Landlord of bills and invoices indicating that such costs permitted by Section 23.3 have been incurred. If Tenant has complied with the
provisions of this Article 23 for payment of any portion of the TI Allowance and Landlord wrongfully fails to make such payment within (30) days after notice from Tenant, Tenant may offset against Rent next coming due and place into an
escrow account any and all of such offset amounts that Landlord may have wrongfully failed to advance, pending resolution by mutual agreement, court of competent jurisdiction, or independent third party mediator or arbitrator of any dispute between
the parties related thereto. 
 Section 23.5 Tenant shall have until the date that is six (6) months after the 777
Premises Commencement Date (the “TI Deadline”), to expend the unused portion of the TI Allowance, after which date Landlord’s obligation to fund such costs shall expire. If Tenant has not applied all of the TI Allowance to the
Tenant Improvements as of the TI Deadline, then Landlord shall credit such unused balance against the next Rental payment coming due after the TI Deadline and any successive Rental payment coming due until the TI Allowance is exhausted.
Notwithstanding the foregoing, in no event shall the TI Allowance Rental credit exceed Two Hundred Eighty-Nine Thousand Four Hundred Seventy-Five Dollars ($289,475) (equal to twenty-five percent (25%) of the TI Allowance). 

Section 23.6 Landlord shall not be obligated to expend or disburse any portion of the TI Allowance until Landlord shall have
received from Tenant sufficient evidence that Tenant has complied with the requirements of Article 6. Landlord may elect to pay Tenant’s contractors directly. 
 ARTICLE 24 
 NO WAIVER 

Section 24.1 No act or thing done by Landlord or Landlord’s agents during the Term shall be deemed an acceptance of a surrender
of the Premises, and no agreement to accept such surrender shall be valid unless in writing signed by Landlord. No employee of Landlord or of 

  
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Landlord’s agents shall have any power to accept the keys to the Premises prior to the termination of this Lease. The delivery of keys to any employee of Landlord or of Landlord’s
agents shall not operate as a termination of this Lease or a surrender of the Premises. If Tenant shall at any time desire to have Landlord sublet the Premises for Tenant’s account, Landlord or Landlord’s agents are authorized to receive
the keys for such purpose without releasing Tenant from any of the obligations under this Lease, and Tenant hereby relieves Landlord of any liability for loss of or damage to any of Tenant’s effects in connection with such subletting.

 Section 24.2 The failure of Landlord to seek redress for violation of, or to insist upon the strict performance of, any
covenant or condition of this Lease, or any of the Rules and Regulations, shall not prevent a subsequent act, which would have originally constituted a violation, from having all of the force and effect of an original violation. The receipt by
Landlord of Fixed Rent, Additional Rent or any other item of Rental with knowledge of the breach of any covenant of this Lease shall not be deemed a waiver of such breach. The failure of Landlord to enforce any of the Rules and Regulations against
Tenant or any other tenant in a Building shall not be deemed a waiver of any such Rules and Regulations. No provision of this Lease shall be deemed to have been waived by Landlord, unless such waiver shall be in writing and shall be signed by
Landlord. No payment by Tenant or receipt by Landlord of a lesser amount than the Rental then due and payable shall be deemed to be other than on account of the earliest item(s) of Rental, or as Landlord may elect to apply the same, nor shall any
endorsement or statement on any check or any letter accompanying any check or payment be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance due of the
Rental or pursue any other remedy in this Lease provided. This Lease contains the entire agreement between the parties and all prior negotiations and agreements are merged herein. Any executory agreement hereafter made shall be ineffective to
change, discharge or effect an abandonment of this Lease in whole or in part unless such executory agreement is in writing and signed by the party against whom enforcement of the change, discharge or abandonment is sought. 

ARTICLE 25 

WAIVER OF TRIAL BY JURY 
 Section 25.1 Landlord and Tenant shall and they hereby do waive trial by jury in any action, proceeding or counterclaim brought by either of them against the other on any matters whatsoever arising
out of or in any way connected with this Lease, the relationship of Landlord and Tenant, Tenant’s use or occupancy of the Premises, whether during or after the Term, or for the enforcement of any remedy under any statute, emergency or
otherwise. If Landlord shall commence any summary proceeding against Tenant, Tenant will not interpose any counterclaim of whatever nature or description in any such proceeding (unless failure to interpose such counterclaim would preclude Tenant
from asserting in a separate action the claim which is the subject of such counterclaim), and will not seek to consolidate such proceeding with any other action which may have been or will be brought in any other court by Tenant or Landlord.

  
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 ARTICLE 26 
 INABILITY TO PERFORM 
 Section 26.1 This Lease and the obligation of
Tenant to pay Rental hereunder and to perform all of the other covenants and agreements hereunder on the part of Tenant to be performed shall in no way be affected, impaired or excused because Landlord is unable to fulfill any of Landlord’s
obligations under this Lease, expressly or implicitly to be performed by Landlord, or because Landlord is unable to make or is delayed in making any repairs, additions, alterations, improvements or decorations, or is unable to supply or is delayed
in supplying any services, equipment or fixtures, if Landlord is prevented from or delayed in so doing by reason of acts of God, casualty, strikes or labor troubles, accident, governmental preemption in connection with an emergency, Requirements,
conditions of supply and demand which have been or are affected by war or other emergency, or any other cause whatsoever (but not lack of funds), whether similar or dissimilar to the foregoing, beyond Landlord’s reasonable control
(“Unavoidable Delays”). 
 ARTICLE 27 

BILLS AND NOTICES 
 Section 27.1 A Except as otherwise expressly provided in this Lease, any bills, statements, consents, approvals, notices, demands, requests or other communications given or required to be given under
this Lease (“Notice(s)”) shall be in writing and shall be deemed sufficiently given or rendered if delivered by hand (against a signed receipt), by a recognized overnight courier service (with a signed receipt), or if deposited in a
securely fastened, postage prepaid envelope in a depository that is regularly maintained by the U.S. Postal Service, sent by registered or certified mail (return receipt requested) and in any case addressed: 

if to Tenant (a) at Tenant’s address set forth in this Lease, if given prior to
Tenant’s taking possession of the Premises, to the attention of Tenant’s Chief Financial Officer, or (b) at the 777 Building, if given subsequent to Tenant’s taking possession of the Premises, to the attention of Tenant’s
Chief Financial Officer, or (c) at any place where Tenant or any agent or employee of Tenant may be found if given subsequent to Tenant’s vacating, deserting, abandoning or surrendering the Premises, but in all events with a copy to Schiff
Hardin LLP, 900 Third Avenue, 23rd Floor, New York, New
York, 10022, Attention: Paul G. Mackey, Esq., or 
 if to Landlord, at Landlord’s address set forth in this
Lease, Attn: Vice President, Real Estate Counsel (ii) any Mortgagee or Lessor who may have requested the same, by Notice given in accordance with the provisions of this Article 27, at the address designated by such Mortgagee or Lessor,
or 
 to such other address(es) as either Landlord or Tenant may designate as its new address(es) for such purpose by notice given to the other
in accordance with the provisions of this Article 27. 

  
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 (B) Notices shall be deemed to have been rendered or given (i) on the Business Day
delivered, if delivered by hand or by recognized overnight courier service, prior to 5:00 p.m. of such Business Day, or if delivered on a day other than a Business Day or after 5:00 p.m. on any day, then on the next Business Day following such
delivery, or (ii) two (2) Business Days after the date mailed, if mailed as provided in Section 27.1(A). Notice given by counsel for either party on behalf of such party or by the Manager on behalf of Landlord shall be deemed
valid notices if addressed and sent in accordance with the provisions of this Article 27. 
 Section 27.2
Notwithstanding the provisions of Section 27.1, Notices requesting services for Overtime Periods pursuant to Article 28 may be given by delivery to a Building superintendent or any other person in a Building designated by Landlord
to receive such Notices, and bills may be rendered by delivering them to the Premises without the necessity of a receipt. 

ARTICLE 28 

SERVICES AND EQUIPMENT 
 Section 28.1 Landlord shall (subject to Tenant’s reimbursement obligation pursuant to Article 4): 
 (A) Provide passenger elevator service to the Premises twenty-four (24) hours per day, seven (7) days per week, three hundred sixty-five (365) days per year. Tenant agrees that Landlord
may, at its election, install elevators with or without operators and may change the same from time to time. 
 (B) Provide one
(1) freight elevator serving the 769 Premises on call on a “first come, first served” basis twenty-four (24) hours per day, seven (7) days per week, three hundred sixty-five (365) days per year. To the extent the 771
Premises and 769 Premises do not have dedicated freight elevators, the passenger elevators may be used for freight in accordance the Requirements. 
 (C) Maintain and repair the HVAC System installed by Landlord, except for those repairs which are the obligation of Tenant pursuant to Article 7 of this Lease. The HVAC System will be operated by
Landlord as and for the comfortable occupancy of the Premises in accordance with the following standards during Operating Hours: 
  

					
	 Design Condition
	  	 Inside Condition
	  	 Outside Condition

			
	 Cooling Cycle
	  	72 degrees F (D.B.F)	  	90 degrees F (D.B.F)
		  		  	77 degrees F (W.B.F)
			
	 Heating Cycle
	  	69 degrees F	  	0 degrees F

 provided that Tenant shall draw and close the draperies or blinds for the windows of the Premises whenever the
ventilation or air-conditioning system is in operation and the position of the sun so requires and shall, at all times, cooperate fully with Landlord and abide by all of the 

  
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Rules and Regulations which Landlord may prescribe for the proper functioning of the HVAC System. Tenant shall pay Landlord for heat, ventilating and air-conditioning as Additional Rent, within
ten (10) days after Landlord bills Tenant therefor, which bills shall be rendered not more often than monthly. The amount of such Additional Rent for a given period of time shall be equal to the total cost to Landlord of delivering steam and
chilled water for the Premises, which cost shall be determined based upon Landlord’s established mathematical model as described in Schedule G hereto. The performance by Landlord of its obligations under this Section 28.1(C)
subject to Tenant’s compliance with the conditions of occupancy and connected load established by Landlord. Use of the Premises, or any part thereof, in a manner exceeding the heating, ventilating and/or air-conditioning design conditions
(including occupancy and connected electrical load), or rearrangement of partitioning which interferes with normal operation of the heating, ventilating and/or air-conditioning in the Premises, or the use of computer or data processing machines or
other machines or equipment, may require changes in the heating, ventilating and/or air-conditioning systems servicing the Premises, in order to provide comfortable occupancy. Such changes, so occasioned, shall be made by Tenant, at its expense, as
Alterations in accordance with the provisions of Article 6, but only to the extent permitted and upon the conditions set forth in that Article. Tenant expressly acknowledges that some or all windows are or may be hermetically sealed and will
not open and Landlord makes no representation as to the habitability of the Premises at any time the HVAC System is not in operation. Tenant hereby expressly waives any claims against Landlord arising out of the cessation of operation of the HVAC
System, or the suitability of the Premises when the same is not in operation, whether due to normal scheduling or the reasons set forth in Section 28.2. Landlord, throughout the Term, shall have free access to all mechanical
installations of Landlord, including but not limited to air-cooling, fan, ventilating and machine rooms and electrical closets, and Tenant shall not construct partitions or other obstructions that may interfere with Landlord’s free access
thereto, or interfere with the moving of Landlord’s equipment to and from the enclosures containing said installations. Neither Tenant nor Persons Within Tenant’s Control shall at any time enter the said enclosures or tamper with, adjust,
touch or otherwise in any manner affect said mechanical installations. Landlord’s obligations under this Section 28.1(C) are subject to applicable Requirements that may limit the hours or the extent to which Landlord is permitted to
supply HVAC. 
 (D) Furnish hot and cold water for lavatory and drinking and office cleaning purposes. If Tenant requires, uses
or consumes water for any other purposes (including for laboratory purposes), Tenant agrees that Tenant shall, if requested by Landlord, install a meter or meters or other means to measure Tenant’s water consumption, and Tenant further agrees
to pay for the cost of the meter or meters and the installation thereof, and to pay for the maintenance of said meter equipment and/or to pay Landlord’s cost of other means of measuring such water consumption by Tenant. Tenant shall reimburse
Landlord for the cost of all water consumed (including costs of generating hot water) as measured by said meter or meters or as otherwise measured, including sewer rents, as Additional Rent within ten (10) days after bills are rendered.

 (E) Provided Tenant shall keep the Premises in order, Landlord shall cause the Premises, including the exterior and the
interior of the windows thereof but excluding any laboratory space, to be cleaned in a manner standard to the Buildings and in accordance with the cleaning specifications annexed to this Lease as Schedule D. Tenant shall pay to Landlord on
demand the reasonable costs incurred by Landlord for (a) extra cleaning work in the Premises required because of (i) misuse or neglect on the part of Tenant or its subtenants or its or their 

  
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employees or visitors, (ii) the use of portions of the Premises for special purposes requiring greater or more difficult cleaning work than office areas, (iii) interior glass partitions
or unusual quantity of interior glass surfaces, and (iv) special materials or finishes on items installed by Tenant or its subtenants or its or their employees or visitors or at its or their request; (b) removal from the Premises and the
Buildings of any refuse or rubbish of Tenant in excess of that ordinarily accumulated in business office occupancy or at times other than Landlord’s standard cleaning times; and (c) any additional operating expenses attributable to the use
and occupancy of the Premises by Tenant or its subtenants or its or their employees or visitors other than during Business Hours on Business Days. If, however, any additional cleaning of the Premises is to be done by Tenant, it shall be done at
Tenant’s sole expense, in a manner reasonably satisfactory to Landlord and no one other than persons approved by Landlord shall be permitted to enter the Premises or the Buildings for such purpose. Tenant, at Tenant’s expense, shall cause
the Premises to be exterminated on a monthly basis to the satisfaction of Landlord and additionally shall cause all portions of the Premises used for the storage, preparation, service or consumption of food or beverages to be cleaned daily in a
manner reasonably satisfactory to Landlord, and to be treated against infestation by vermin, rodents or roaches, whenever there is evidence of any infestation. Tenant shall not permit any person to enter the Premises or the Buildings for the purpose
of providing such extermination services, unless such persons have been approved by Landlord. If so requested by Landlord, Tenant, at Tenant’s expense, shall store any refuse generated by the consumption of food or beverages on the Premises in
a cold box or similar facility. Landlord, its cleaning contractor and their employees shall have access to the Premises after 5:30 p.m. and before 9:00 a.m. and shall have the right to use, without charge therefor, all light, power and water in the
Premises reasonably required to clean the Premises as required under Section 28.1. Tenant shall comply, at Tenant’s expense, with all Requirements regarding recycling of trash including, but not limited to, separating from the
general trash such items as may be required, i.e., paper, plastic, glass and aluminum cans. 
 (F) Intentionally omitted.

 (G) Landlord shall provide security devices and services for the Buildings and key card access to the Premises, consistent
with the standards of the Original Premises, but Landlord shall not be obligated to provide any access devices such as security card readers or security devices within the Premises. Tenant acknowledges that security devices and services, if any,
while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any security device or
service may malfunction or otherwise be circumvented by a criminal and waives any claim against Landlord arising out of or in connection with the failure of any security service or device. If Tenant desires protection against such criminal acts,
then Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage. 
 Section 28.2
(A) Landlord reserves the right to stop the furnishing of the Building services and to stop service of the Building Systems, when necessary, by reason of accident, or emergency, or for Alterations in the judgment of Landlord desirable or
necessary to be made, until said Alterations shall have been completed; and Landlord shall have no responsibility or liability for failure to supply air-conditioning, ventilation, heat, elevator, plumbing, electric, gas, steam or other services
during said period or when prevented from so doing by strikes, lockouts, difficulty of obtaining materials, accidents or by any cause beyond Landlord’s reasonable 

  
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control, or by Requirements or failure of electricity, water, steam, coal, oil or other suitable fuel or power supply, or inability by exercise of reasonable diligence to obtain electricity,
water, steam, coal, oil or other suitable fuel or power. No diminution or abatement of rent or other compensation shall or will be claimed by Tenant as a result therefrom, nor shall this Lease or any of the obligations of Tenant be affected or
reduced by reason of such interruption, curtailment or suspension, nor shall the same constitute an actual or constructive eviction. 
 (B) If, by reason of Landlord’s failure to make repairs or replacements required to be made by Landlord pursuant to this Lease (a “Landlord Failure”), the Building HVAC System, the
Building electrical system, the Building elevators, or the Building plumbing/water system serving the Premises shall become inoperable, and as a result thereof a material portion of the Premises is rendered untenantable and Tenant ceases to use such
portion of the Premises for the conduct of its business and such Landlord Failure continues unremedied for more than ten (10) consecutive days after Tenant gives written notice to Landlord of the Landlord Failure and the fact that a material
portion of the Premises has been rendered untenantable by reason of such Landlord Failure and that Tenant shall have ceased using such portion of the Premises for the conduct of its business, then the Fixed Rent shall be abated during the time that
such portion remains untenantable and unused by reason of such Landlord Failure after such tenth (10th) day, apportioned according to the rentable area of the Premises so rendered untenantable and unused. Nothing contained in this
Section 28.2(B) is intended to, or shall be deemed to, make any event described in or contemplated by Articles 13, 14 or 39.2 or any event resulting from an act or omission of Tenant or Persons Within Tenant’s Control a
Landlord Failure. 
 Section 28.3 Tenant agrees to abide by all requirements which Landlord may prescribe for the proper
protection and functioning of its Building Systems and the furnishing of the Building services. Tenant further agrees to cooperate with Landlord in any conservation effort pursuant to a program or procedure promulgated or recommended by ASHRAE or
any Requirements. 
 Section 28.4 (A) If Landlord shall furnish either gas or steam to the Premises, Landlord shall
not be liable in any event to Tenant for any failure or defect in the supply or character of the gas or steam furnished to the Premises by reason of any requirement, act or omission of the public utility or other provider serving a Building with
steam or for any other reason not attributable solely to Landlord’s willful misconduct or gross negligence. Tenant’s use of gas or steam in the Premises shall not at any time exceed the capacity of any of the gas lines and equipment or
steam lines and equipment in or otherwise then serving the Premises. 
 (B) If Landlord shall furnish gas to the Premises,
Landlord shall, at Tenant’s expense, install a meter or meters to measure consumption in the Premises and Tenant shall pay Landlord for the gas consumed at Landlord’s cost. 

Section 28.5 Landlord shall have no obligation to clean, repair, replace or maintain any “private” plumbing fixtures or
facilities (i.e., plumbing fixtures and facilities other than those that would be the common toilets in a multi-tenant floor) or the rooms in which they are located. 
 Section 28.6 Tenant acknowledges that Landlord may establish a messenger center in the lobby or other public portion of a Building or another building on the Real Property. In such

  
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event, Landlord shall notify Tenant of the establishment, location and hours of operation of the messenger center and, thereafter, (i) all deliveries to Tenant shall be made to the messenger
center and not to the Premises and (ii) no messenger shall be permitted in the passenger or freight elevators of a Building. Landlord may operate a messenger center consistent with first class office buildings in Westchester County in
accordance with procedures, rules and regulations prescribed by Landlord from time to time. Tenant and Persons Within Tenant’s Control shall comply with such procedures, rules and regulations. Landlord shall not enforce such Rules and
Regulations against Tenant in a discriminating manner. 
 ARTICLE 29 

PARTNERSHIP TENANT 
 Section 29.1 If Tenant is a partnership, or is comprised of two (2) or more persons, individually or as co-partners of a partnership (any such partnership and such persons are referred to in
this Article 29 as “Partnership Tenant”), or if Tenant’s interest in this Lease shall be assigned to a Partnership Tenant, the following provisions shall apply to such Partnership Tenant: (a) the liability of each
of the parties comprising Partnership Tenant shall be joint and several; (b) each of the parties comprising Partnership Tenant hereby consents in advance to, and agrees to be bound by (i) any written agreement that may hereafter be
executed by Partnership Tenant or any successor entity, changing, extending or discharging this Lease, in whole or in part, or surrendering all or any part of the Premises to Landlord, and (ii) any Notices that may hereafter be given by
Partnership Tenant or by any of the parties comprising Partnership Tenant; (c) any Notices given or rendered to Partnership Tenant or to any of such parties shall be binding upon Partnership Tenant and all such parties; (d) if Partnership
Tenant admits new partners, all of such new partners shall, by their admission to Partnership Tenant, be deemed to have assumed joint and several liability for the performance of all of the terms, covenants and conditions of this Lease on
Tenant’s part to be observed and performed; (e) Partnership Tenant shall give prompt notice to Landlord of the admission of any such new partners, and upon demand of Landlord, shall cause each such new partner to execute and deliver to
Landlord an agreement in form satisfactory to Landlord, wherein each such new partner assumes joint and several liability for the performance of all the terms, covenants and conditions of this Lease on Tenant’s part to be observed and performed
(but neither Landlord’s failure to request any such agreement nor the failure of any such new partner to execute or deliver any such agreement to Landlord shall vitiate the provisions of clause (d) of this Article 29); and
(f) any present or future partner of Partnership Tenant who is no longer a partner of Partnership Tenant at the time of any default under this Lease shall, nevertheless, remain liable for the obligations of Tenant under this Lease, as if any
such partner had been a partner of Partnership Tenant on the date of such default. 
 ARTICLE 30 

ELECTRIC ENERGY 
 Section 30.1 Subject to the provisions of this Article, Landlord shall furnish the electric energy that Tenant shall reasonably require in the Premises for the Permitted Use. Except for electric
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ventilating and conditioning to the Premises (“HVAC Electric”), such electric energy may, at Landlord’s option, be furnished through a meter or meters and related equipment,
installed and maintained by Landlord at Tenant’s expense, measuring the amount of electric energy furnished to the Premises. Tenant shall pay Landlord for such electric energy as Additional Rent, within ten (10) days after Landlord bills Tenant
therefor, which bills shall be rendered not more often than monthly. The amount of such Additional Rent (a) for HVAC Electric shall be equal to Landlord’s cost, as determined pursuant to Section 28.1, and (b) for other electric energy
furnished to the Premises (“Basic Electric”) shall be equal to Landlord’s actual cost, applied to the readings on each such meter or meters, including in each case, without limitation, those charges applicable to or computed on
the basis of electric consumption, demand and hours of use, any sales or other taxes regularly passed on to or collected from similar consumers by such public utility company, fuel rate adjustments and surcharges, and weighted in each case to
reflect differences in consumption or demand applicable to each rate level (taking into account the benefit of any “business incentive rate” that is payable by Landlord). Tenant and its authorized representatives may have access to such
meter or meters (if any) on at least three (3) days’ notice to Landlord, for the purposes of verifying Landlord’s meter readings (if any). Except with respect to the 777 Premises, from time to time during the Term of this Lease, Landlord
may, in its sole discretion, install or eliminate, or increase or reduce the number of, such meters or vary the portions of the Premises which they serve or replace any or all of such meters. 

Section 30.2 If pursuant to any Requirements, the charges to Tenant pursuant to Section 30.1 shall be reduced below that
to which Landlord is entitled under such Section, the deficiency shall be paid by Tenant within ten (10) days after being billed therefor, as Additional Rent for the use and maintenance of the electric distribution system of a Building.

 Section 30.3 Landlord shall not be liable in any event to Tenant for any failure or defect in the supply or character of
electric energy furnished to the Premises by reason of any requirement, act or omission of the public utility or other provider serving a Building with electric energy or for any other reason not attributable solely to Landlord’s willful
misconduct or gross negligence. 
 Section 30.4 Landlord shall furnish and install all replacement lighting tubes, lamps,
bulbs and ballasts required in the Premises, and Tenant shall pay to Landlord or its designated contractor upon demand the then established reasonable charges therefor of Landlord or its designated contractor, as the case may be. 

Section 30.5 Tenant’s use of electric energy in the Premises shall not at any time exceed the capacity of any of the electrical
conductors and equipment in or otherwise serving the Premises. In order to insure that such capacity is not exceeded and to avert possible adverse effect upon a Building’s distribution of electricity via a Building’s electric system,
Tenant shall not, without Landlord’s prior consent in each instance (which shall not be unreasonably withheld, based upon availability of electric energy in a Building as allocated by Landlord to various areas of a Building) make any
alterations or additions to the electric system of the Premises existing on the Commencement Date. Should Landlord grant such consent, all additional risers or other equipment required therefor shall be provided by Landlord and the cost thereof
shall be paid by Tenant to Landlord on demand. Landlord shall have the right to require Tenant to pay sums on account of such cost prior to the installation of any such risers or equipment. 

  
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 Section 30.6 Landlord, upon at least sixty (60) days’ notice to Tenant, (and
after Tenant is able and the Premises are equipped to receive electric energy directly from the utility company, as hereinafter provided), may discontinue Landlord’s provision of electric energy (or either HVAC Electric or Basic Electric, as
the case may be) hereunder. If Landlord discontinues provision of electric energy pursuant to this Section, Tenant shall not be released from any liability under this Lease, except that as of the date of such discontinuance, Tenant’s obligation
to pay Landlord Additional Rent under Section 30.1 for electric energy (or either HVAC Electric or Basic Electric, as the case may be) thereafter supplied to the Premises shall cease. As of such date, Landlord shall permit Tenant to
receive electric energy directly from the public utility company or other provider supplying electric energy to the Project, and Tenant shall pay all costs and expenses of obtaining such direct electrical service. Such electric energy may be
furnished to Tenant by means of the then existing Building system feeders, risers and wiring to the extent that the same are available, suitable and safe for such purpose. All additional meters and additional panel boards, feeders, risers, wiring
and other conductors and equipment which may be required to obtain electric energy directly from such public utility company or other provider shall be furnished and installed by Landlord at Landlord’s expense (which, to the extent not already
in place, shall constitute an Operating Expense, amortized on a straight line basis over the useful life of the items in question, as reasonably determined by Landlord). 
 ARTICLE 31 
 SIGNS 

Section 31.1 The location, size, materials, quality, design, color and lettering of any signs desired by Tenant shall be subject to
the prior approval of Landlord (not to be unreasonably withheld or delayed) and shall be in compliance with the standards promulgated by Landlord. At Landlord’s option, Landlord may install any such signs, and Tenant shall pay all costs
associated with such installation, as Additional Rent, within ten (10) days after demand therefor. Without limiting the generality of the foregoing, Tenant shall have the right, as part of the Tenant Improvements, to install exterior Building
signage comparable with that of other tenants in the Existing Project occupying all or substantially all of an entire building, in accordance with this Article 31 for the 771 Premises, at Tenant’s sole cost and expense. 

ARTICLE 32 

BROKER 

Section 32.1 Landlord represents and warrants to Tenant that Landlord has not dealt with any broker or Person in connection with this
Lease other than the Broker. Tenant represents and warrants to Landlord that Tenant has not dealt with any broker or Person in connection with this Lease other than the Broker. The execution and delivery of this Lease by each party shall be
conclusive evidence that such party acknowledges that each party has relied upon the foregoing representation and warranty. Landlord and Tenant each shall indemnify and hold harmless the other from and against any and all claims for commission, fee
or other compensation by any Person other than the Broker who claims to have dealt with such party in connection with this Lease and for any and all costs incurred by the indemnified party in connection with such claims,

  
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including, without limitation, reasonable attorneys’ fees and disbursements. Landlord shall indemnify and hold harmless Tenant from and against any and ail claims for commission, fee or
other compensation by the Broker in connection with this Lease and for any and all costs incurred by the indemnified party in connection with such claims, including, without limitation, reasonable attorneys’ fees and disbursements. Landlord
shall compensate Broker pursuant to a separate agreement between Broker and Landlord. This provision shall survive the expiration or earlier termination of this Lease. 
 ARTICLE 33 
 INDEMNITY 

Section 33.1 Tenant shall not do or permit any act or thing to be done upon the Premises or the Real Property that may subject any
Indemnitee to any liability or responsibility for injury, damage to persons or property or to any liability by reason of the existence or application of, compliance with or violation of any Requirement, but shall exercise such control over the
Premises as to protect each Indemnitee fully against any such liability and responsibility. Tenant shall indemnify and save harmless the Indemnitees from and against (a) all claims of whatever nature against the Indemnitees arising from any act,
omission or negligence of Tenant or Persons Within Tenant’s Control, (b) all claims against the Indemnitees arising from any accident, injury or damage whatsoever caused to any person or to the property of any person and occurring in or
about the Premises during the Term or during Tenant’s occupancy of the Premises (unless caused by Landlord’s negligence or willful misconduct), (c) all claims against the Indemnitees arising from any accident, injury or damage
occurring outside of the Premises but anywhere within or about the Real Property, where such accident, injury or damage results or is claimed to have resulted from an act, omission or negligence of Tenant or Persons Within Tenant’s Control, and
(d) any breach, violation or non-performance of any covenant, condition or agreement contained in this Lease to be fulfilled, kept, observed and performed by Tenant. This indemnity and hold harmless agreement shall include indemnity from and
against any and all liability, fines, suits, demands, costs and expenses of any kind or nature (including, without limitation, attorneys’ fees and disbursements) incurred in or in connection with any such claim or proceeding brought thereon,
and the defense thereof. 
 Section 33.2 If any claim, action or proceeding is made or brought against any Indemnitee,
against which claim, action or proceeding Tenant is obligated to indemnify such Indemnitee pursuant to the terms of this Lease, then, upon demand by the Indemnitee, Tenant, at its sole cost and expense, shall resist or defend such claim, action or
proceeding in the Indemnitee’s name, if necessary, by counsel reasonably satisfactory to Landlord. Counsel selected by Tenant’s insurance company shall be deemed satisfactory to Landlord. Notwithstanding the foregoing, if such attorneys
shall be defending both Tenant or any Persons Within Tenant’s Control and an Indemnitee, such Indemnitee may, if it reasonable determines that there is a potential conflict of interest or the matter involves claims in excess of $3,000,000,
retain its own attorneys to defend or assist in defending any claim, action or proceeding, and Tenant shall pay the reasonable fees and disbursements of such attorneys. The provisions of this Article 33 shall survive the expiration or earlier
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 ARTICLE 34 
 PARKING 
 Section 34.1 Landlord shall, without charge to Tenant
(except as consequence of the cost thereof being included in Operating Expenses), provide and maintain, (a) for the nonexclusive use of Tenant’s employees and invitees, parking areas sufficient to accommodate that number of standard size
automobiles as shall be equal to the Number of Parking Spaces set forth in the Reference Page in the area(s) shown on the plan attached hereto as Schedule H, and (b) for the exclusive use of Tenant’s employees and invitees, parking
areas sufficient to accommodate that number of standard size automobiles as shall be equal to the Number of Parking Spaces set forth in the Reference Page in the area(s) shown on the plan attached hereto as Schedule H. In the event Landlord
utilizes such parking areas for Landlord’s development purposes, Landlord will provide Tenant with substantially equivalent number of parking facilities. 
 ARTICLE 35 
 SECURITY DEPOSIT 

Section 35.1 Tenant has deposited with Landlord the Security Deposit by Letter of Credit (as defined and further described in
Section 35.2), as security for the faithful performance and observance by Tenant of the terms, provisions and conditions of this Lease. Tenant agrees that in the event (i) of the occurrence of an Event of Default, (ii) Tenant
has defaulted in the performance of any of its obligations under this Lease, including the payment of any item of Rental, and the transmittal of a Notice of default by Landlord is barred by applicable law, (iii) as of the date thirty
(30) days before any Letter of Credit expires (even if such scheduled expiry date is after the Expiration Date) either (x) in the case of a Letter of Credit with automatic an renewal provision, such letter of credit is not automatically
renewed, or (y) Tenant has not delivered to Landlord an amendment or replacement for such Letter of Credit, reasonably satisfactory to Landlord, extending the expiry date to the earlier of (1) three (3) months after the then-current
Term Expiration Date, or (2) the date one year after the then-current expiry date of the Letter of Credit; (iv) the Letter of Credit provides for automatic renewals, Landlord asks the issuer to confirm the current Letter of Credit expiry
date, and the issuer fails to do so within thirty (30) days; (v) Tenant fails to pay (when and as Landlord reasonably requires) any bank charges within ten (10) Business Days for Landlord’s transfer of the Letter of Credit to a
successor Landlord or Mortgagee; or (vi) the issuer of the Letter of Credit ceases, or announces that it will cease, to maintain an office within twenty (20) miles of the city listed on the Letter of Credit (unless the Letter of Credit
states that Landlord may present the Letter of Credit for a draw via facsimile) where Landlord may present drafts under the Letter of Credit, then Landlord may draw the entire amount of the Letter of Credit and use, apply or retain the whole or any
part of such proceeds, to the extent required for the payment of any Fixed Rent, Additional Rent, or any other sum as to which Tenant is in default, or for any sum that Landlord may expend or may be required to expend by reason of the default
(including any damages or deficiency accrued before or after summary proceedings or other re-entry by Landlord). If Landlord applies or retains any portion or ail of the proceeds of the Letter of Credit, Tenant shall forthwith restore the amount so
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all times, the amount of the Security Deposit shall be the amount set forth on the Reference Page. Provided there is no uncured default, any balance of the proceeds of the Letter of Credit held
by Landlord and not used, applied or retained by Landlord as above provided, and any remaining Letter of Credit, shall be returned to Tenant within thirty (30) days after the Expiration Date and after delivery of possession of the entire Premises to
Landlord in accordance with the terms of this Lease. 
 Section 35.2 Tenant shall deliver to Landlord a clean, irrevocable
and unconditional letter of credit (such letter of credit, and any replacement thereof as provided herein, is called a “Letter of Credit”) issued and drawn upon any commercial bank approved by Landlord with offices for banking
purposes in the City of New York (“Issuing Bank”), which Letter of Credit shall have a term of not less than one year, be in form and content satisfactory to Landlord, be for the account of Landlord and be in the amount of the
Security Deposit set forth in the Reference Page. Landlord may require the Letter of Credit to be re-issued by a different Issuing Bank at any time during the Term if Landlord reasonably believes that the Issuing Bank is or may soon become
insolvent; provided, however, Landlord shall return the existing Letter of Credit to the existing issuer promptly upon receipt of the substitute Letter of Credit. If any issuer of the Letter of Credit shall become insolvent or placed into FDIC
receivership, then Tenant shall immediately deliver to Landlord (without the requirement of notice from Landlord) substitute Letter of Credit issued by an issuer reasonably satisfactory to Landlord, and otherwise conforming to the requirements set
forth in this Article 35. As used herein with respect to the issuer of the Letter of Credit, “insolvent” shall mean the determination of insolvency as made by such issuer’s primary bank regulator (i.e., the state bank
supervisor for state chartered banks; the OCC or OTS, respectively, for federally chartered banks or thrifts; or the Federal Reserve for its member banks). The existing Letter of Credit currently held by Landlord, as well as the form of letter of
credit annexed to this Lease as Schedule F, are satisfactory. The Letter of Credit shall provide that: 
 (1) The
Issuing Bank shall pay to Landlord or its duly authorized representative an amount up to the face amount of the Letter of Credit upon presentation of the Letter of Credit and a sight draft in the amount to be drawn; 

(2) The Letter of Credit shall be deemed to be automatically renewed, without amendment, for consecutive periods of one year each during
the Term, unless the Issuing Bank sends written notice (the “Non-Renewal Notice”) to Landlord by certified or registered mail, return receipt requested, at least thirty (30) days prior to the expiration date of the Letter of
Credit, to the effect that it elects not to have such Letter of Credit renewed; 
 (3) The Letter of Credit delivered in
respect of the last year of the Term shall have an expiration date of not earlier than thirty (30) days after the Fixed Expiration Date; and 
 (4) The Letter of Credit shall be transferable by Landlord as provided in Section 35.4. 
 Section 35.3 Landlord, after receipt of the Non-Renewal Notice, shall have the right to draw the entire amount of the Letter of Credit and to hold the proceeds as a cash Security Deposit. Landlord
shall release such proceeds to Tenant upon delivery to Landlord of a replacement Letter of Credit complying with the terms hereof. 

  
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 Section 35.4 In the event of the sale or lease of the Buildings or the Real Property,
Landlord shall have the right to transfer the Security Deposit, without charge for such transfer, to the purchaser or lessee, and Landlord shall thereupon be released by Tenant from all liability for the return of such Security Deposit. In such
event, Tenant agrees to look solely to the new Landlord for the return of said Security Deposit. It is agreed that the provisions hereof shall apply to every transfer or assignment made of the Security Deposit to a new Landlord. Tenant shall execute
such documents as may be necessary to accomplish such transfer or assignment of the Letter of Credit. 
 Section 35.5
Tenant covenants that it will not assign or encumber, or attempt to assign or encumber, the Security Deposit held hereunder, and that neither Landlord nor its successors or assigns shall be bound by any such assignment, encumbrance, attempted
assignment, or attempted encumbrance. In the event that any bankruptcy, insolvency, reorganization or other debtor-creditor proceedings shall be instituted by or against Tenant, its successors or assigns, or any guarantor of Tenant hereunder, the
security shall be deemed to be applied to the payment of the Fixed Rent and Additional Rent due Landlord for periods prior to the institution of such proceedings and the balance, if any, may be retained by Landlord in partial satisfaction of
Landlord’s damages. 
 ARTICLE 36 
 RENT REGULATION 
 Section 36.1 If at any time or times during the Term
of this Lease, the Rental reserved in this Lease is not fully collectible by reason of any Requirement, Tenant shall enter into such agreements and take such other steps (without additional expense to Tenant) as Landlord may request and as may be
legally permissible to permit Landlord to collect the maximum rents that may from time to time during the continuance of such legal rent restriction be legally permissible (and not in excess of the amounts reserved under this Lease). Upon the
termination of such legal rent restriction (a) the Rental shall become and thereafter be payable hereunder in accordance with the amounts reserved in this Lease for the remainder of the Term, and (b) Tenant shall pay to Landlord, if
legally permissible, an amount equal to (i) the items of Rental that would have been paid pursuant to this Lease but for such legal rent restriction less (ii) the rents paid by Tenant to Landlord during the period or periods such legal
rent restriction was in effect. This provision shall survive the expiration or earlier termination of this Lease to the maximum enforceable extent. 

  
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 ARTICLE 37 
 [INTENTIONALLY OMITTED] 
 ARTICLE 38 

COVENANT OF QUIET ENJOYMENT 
 Section 38.1 Landlord covenants that, upon Tenant paying the Fixed Rent and Additional Rent and observing and performing all the terms, agreements, covenants, provisions and conditions of this Lease
on Tenant’s part to be observed and performed, Tenant may peaceably and quietly enjoy the Premises, and provided further that this covenant shall bind and be enforceable against Landlord or any successor to Landlord’s interest, subject to
the terms hereof, only so long as Landlord or any successor to Landlord’s interest, is in possession and is collecting rent from Tenant but not thereafter. 
 ARTICLE 39 
 MISCELLANEOUS 

Section 39.1 This Lease is presented for signature by Tenant and it is understood that this Lease shall not constitute an offer by
or be binding upon Landlord unless and until Landlord shall have executed and delivered a fully executed copy of this Lease to Tenant. 
 Section 39.2 The obligations of Landlord under this Lease shall not be binding upon Landlord named herein after the sale, conveyance, assignment or transfer by such Landlord (or upon any subsequent
landlord after the sale, conveyance, assignment or transfer by such subsequent landlord) of its interest in the Buildings or the Real Property, as the case may be, and in the event of any such sale, conveyance, assignment or transfer, Landlord shall
be and hereby is entirely freed and relieved of all covenants and obligations of Landlord under this Lease thereafter arising, and the transferee shall be deemed to have assumed, subject to the remaining provisions of this Section 39.2,
all obligations of the Landlord under this Lease arising after the effective date of the transfer. No member, trustee, partner, shareholder, director or officer of Landlord, or of any partner or shareholder of Landlord (collectively, the
“Parties”) shall have any direct or personal liability for the performance of Landlord’s obligations under this Lease, and Tenant shall look solely to Landlord’s interest in the Real Property to enforce Landlord’s
obligations hereunder and shall not otherwise seek any damages against Landlord personally or any of the Parties whatsoever. Tenant shall not look to any other property or assets of Landlord or any property or assets of any of the Parties in seeking
either to enforce Landlord’s obligations under this Lease or to satisfy a judgment for Landlord’s failure to perform such obligations. 
 Section 39.3 Notwithstanding anything contained in this Lease to the contrary, all amounts payable by Tenant to or on behalf of Landlord under this Lease, whether or not expressly denominated Fixed
Rent, Additional Rent or Rental, shall constitute rent for the purposes of Section 502(b)(7) of the Bankruptcy Code. 

  
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 Section 39.4 Tenant shall be permitted, at Tenant’s sole cost and expense, to
record a memorandum of this Lease in a form reasonably approved by Landlord, provided that Tenant deliver to Landlord, simultaneously with the delivery of such memorandum, a termination and release of such memorandum which is in recordable form and
is executed and notarized by an authorized officer of Tenant. Landlord shall be entitled to in record such release at the expiration, termination or surrender of Tenant’s interest in the Lease and the Premises or material portion thereof.

 Section 39.5 Except as otherwise expressly stated in this Lease, any consent or approval required to be obtained from
Landlord may be granted by Landlord in its sole discretion. In any instance in which Landlord agrees not to act unreasonably, Tenant hereby waives any claim for damages against or liability of Landlord that Tenant may have based upon any assertion
that Landlord has unreasonably withheld or unreasonably delayed any consent or approval requested by Tenant, and Tenant agrees that its sole remedy shall be an action or proceeding to enforce any related provision or for specific performance,
injunction or declaratory judgment, provided that, the successful party in any such action shall be entitled to recover its costs and expenses, including reasonable attorneys’ fees and expenses. If with respect to any required consent or
approval Landlord is required by the express provisions of this Lease not to unreasonably withhold or delay its consent or approval, and if it is determined in any such proceeding referred to in the preceding sentence that Landlord acted
unreasonably, the requested consent or approval shall be deemed to have been granted; however, Landlord shall have no liability whatsoever to Tenant for its refusal or failure to give such consent or approval. Tenant’s sole remedy for
Landlord’s unreasonably withholding or delaying consent or approval shall be as provided in this Section 39.5. 

Section 39.6 Notwithstanding anything contained in this Lease or indicated on any sketch, blueprint or plan, any vaults, vault space
or other space outside the boundaries of the Real Property are not included in the Premises. Landlord makes no representation as to the location of the boundaries of the Real Property. All vaults and vault space and all other space outside the
boundaries of the Real Property which Tenant may be permitted to use or occupy are to be used or occupied under a revocable license, and if any such license is revoked, or if the amount of such space is diminished or required by any Government
Authority or by any public utility company, such revocation, diminution or requisition shall not constitute an actual or constructive eviction, in whole or in part, or entitle Tenant to any abatement or diminution of Rental, or relieve Tenant from
any of its obligations under this Lease, or impose any liability upon Landlord. Any fee, tax or charge imposed by any Government Authority for any such vaults, vault space or other space occupied by Tenant shall be paid by Tenant. 

Section 39.7 If Tenant shall remain in possession of the Premises after the Expiration Date, without the
execution by both Tenant and Landlord of a new lease, Tenant, at the election of Landlord, shall be deemed to be occupying the Premises as a Tenant from month-to-month, at a monthly rental equal to the greater of (a) one and one-half (1 1/2) times the Rental payable during the last month of the Term, and (b) the then fair market value, on a monthly basis, for comparable space, subject to all the other conditions, provisions and
obligations of this Lease insofar as the same are applicable to a month-to-month tenancy. 
 Section 39.8 This Lease
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phrases in this Lease are stricken out or otherwise eliminated, whether or not any other words or phrases have been added, this Lease shall be construed as if the words or phrases so stricken out
or otherwise eliminated were never included in this Lease and no implication or inference shall be drawn from the fact that such words or phrases were stricken out or otherwise eliminated. 

Section 39.9 If any of the provisions of this Lease, or the application thereof to any person or circumstance, shall, to any extent,
be invalid or unenforceable, the remainder of this Lease, or the application of such provisions to persons or circumstances other than those as to whom or which it is held invalid or unenforceable, shall not be affected thereby and shall remain
valid and enforceable, and every provision of this Lease shall be valid and enforceable to the fullest extent permitted by law. 

Section 39.10 Landlord shall have the right to erect any gate, chain or other obstruction or to close off any portion of the Real
Property to the public at any time to the extent necessary to prevent a dedication thereof for public use. 
 Section 39.11
Tenant hereby represents to Landlord that it is not entitled, directly or indirectly, to diplomatic or sovereign immunity and Tenant agrees that in all disputes arising directly or indirectly out of this Lease Tenant shall be subject to service of
process in, and the jurisdiction of the courts of, the State of New York. The provisions of this Section 39.11 shall survive the expiration of this Lease. 
 Section 39.12 This Lease contains the entire agreement between the parties and all prior negotiations and agreements related to the Premises are merged into this Lease. This Lease may not be changed,
abandoned or discharged, in whole or in part, nor may any of its provisions be waived except by a written agreement that (a) expressly refers to this Lease, and (b) is executed by the party against whom enforcement of the change,
abandonment, discharge or waiver is sought. 
 Section 39.13 Any apportionment or prorations of Rental to be made under
this Lease shall be computed on the basis of the calendar year or month as applicable. 
 Section 39.14 This Lease shall be
governed by the laws of the State of New York, without regard to conflict of laws principles. 
 Section 39.15 If Tenant is
a corporation or a limited liability company, each person executing this Lease on behalf of Tenant hereby covenants, represents and warrants that Tenant is duly incorporated, duly formed or duly qualified (if foreign), is in good standing and is
authorized to do business in the State of New York (a copy of evidence thereof to be supplied to Landlord upon request); and that each person executing this Lease on behalf of Tenant is an officer or member of Tenant and that he or she is duly
authorized to execute, acknowledge and deliver this Lease to Landlord (a copy of a resolution or other evidence to that effect to be supplied to Landlord upon request). 
 Section 39.16 The captions are inserted only as a matter of convenience and for reference and in no way define, limit or describe the scope of this Lease nor the intent of any provision thereof.

  
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 Section 39.17 The covenants, conditions and agreements contained in this Lease shall
bind and inure to the benefit of Landlord and Tenant and their respective legal representatives, successors, and, except as otherwise provided in this Lease, their assigns. 
 Section 39.18 There shall be no postponement of the Commencement Date for any delay in the delivery of possession of the Premises which results from any act or omission of Tenant (or Persons within
Tenant’s Control), including delays due to changes in or additions to, or interference with any work to be done by Landlord, or delays by Tenant in submission of plans or information approving working drawings or estimates or giving
authorizations or approvals. 
 Section 39.19 For the purposes of this Lease and all agreements supplemental to this Lease,
unless the context otherwise requires: 
 (a) The words “herein”, “hereof”, “hereunder” and
“hereby” and words of similar import shall be construed to refer to this Lease as a whole and not to any particular Article or Section unless expressly so stated. 
 (b) Tenant’s obligations hereunder shall be construed in every instance as conditions as well as covenants, each separate and independent of any other terms of this Lease. 

(c) Reference to Landlord as having “no liability” or being “without liability” shall mean that Tenant shall not be
entitled to terminate this Lease, or to claim actual or constructive eviction, partial or total, or to receive any abatement or diminution of rent, or to be relieved in any manner of any of its other obligations hereunder, or to be compensated for
loss or injury suffered or to enforce any other right or liability whatsoever against Landlord under or with respect to this Lease or with respect to Tenant’s use or occupancy of the Premises. 

(d) Reference to “termination of this Lease” or “expiration of this Lease” and words of like import includes
expiration or sooner termination of this Lease and the Term and the estate hereby granted or cancellation of this Lease pursuant to any of the provisions of this Lease or to law. Upon the termination of this Lease, the Term and estate granted by
this Lease shall end at noon on the date of termination as if such date were the Fixed Expiration Date, and neither party shall have any further obligation or liability to the other after such termination except (i) as shall be expressly
provided for in this Lease, and (ii) for such obligations as by their nature under the circumstances can only be, or by the provisions of this Lease, may be, performed after such termination, and, in any event, unless expressly otherwise
provided in this Lease, any liability for a payment (which shall be apportioned as of such termination) which shall have accrued to or with respect to any period ending at the time of termination shall survive the termination of this Lease.

 (e) Words and phrases used in the singular shall be deemed to include the plural and vice versa, and nouns and pronouns used
in any particular gender shall be deemed to include any other gender. 
 (f) The rule of “ejusdem generis”
shall not be applicable to limit a general statement following or referable to an enumeration of specific matters to matters similar to the matters specifically mentioned. 

  
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 Section 39.20 If an excavation shall be made upon land adjacent to the Buildings, or
shall be authorized to be made, Tenant shall, upon reasonable advance notice, afford to the person causing or authorized to cause such excavation, license to enter upon the Premises for the purpose of doing such work as said person shall deem
necessary to preserve the walls of the Buildings from injury or damage and to support the same by proper foundations without any claim for eviction or constructive eviction, damages or indemnity against Landlord, or diminution or abatement of
Rental. In the event Landlord is required to enter the Premises as provided in this Section, Landlord shall use reasonable efforts to minimize interference with Tenant’s use and occupancy of the Premises and shall, except in the case of an
emergency, attempt to coordinate with Tenant prior to entering the Premises and performing any work; provided, however, that Landlord shall have no obligation to employ contractors or labor at so-called overtime or other premium pay rates or
to incur any other overtime costs in connection with such work. 
 ARTICLE 40 

[INTENTIONALLY OMITTED] 
 ARTICLE 41 
 [INTENTIONALLY OMITTED] 

ARTICLE 42  
 [INTENTIONALLY OMITTED] 
 ARTICLE 43 

RENEWAL OPTIONS 
 Section 43.1 Provided that (a) this Lease is in full force and effect as of the date of the First Renewal Notice (as hereinafter defined) and the Second Renewal Notice (as hereinafter defined),
as the case may be, (b) there shall not then be existing an Event of Default hereunder and (c) Tenant shall be in actual physical occupancy of at least fifty percent (50%) of the Premises on the date of the applicable Renewal Notice
and upon commencement of the applicable Renewal Term, Tenant shall have two options to extend the Term of this Lease, each for an additional term of five years (respectively, the “First Renewal Term” and the “Second Renewal
Term” and collectively, the “Renewal Terms”), commencing on the day after the Fixed Expiration Date, in the case of the First Renewal Term, and commencing on the day after the last day of the First Renewal Term, in the case
of the Second Renewal Term. Notwithstanding the preceding sentence, Landlord, in its sole discretion, may waive any Event of Default by Tenant and no such Event of Default may be used by Tenant to negate the effectiveness of Tenant’s exercise
of the option(s) hereunder. Tenant’s option with respect to the First Renewal Term shall be exercisable by written notice (the “First Renewal Notice”) to Landlord given not later than twelve (12) months prior to the Fixed
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Second Renewal Term, shall be exercisable by written notice (the “Second Renewal Notice”) to Landlord given not later than twelve (12) months prior to the last day of the
First Renewal Term. The Renewal Terms shall constitute extensions of the initial Term of this Lease and shall be upon all of the same terms and conditions as the initial Term, except that (i) there shall be only one option to renew the term of
this Lease for the Second Renewal Term in the First Renewal Term, and there shall be no further option to renew the term of this Lease in the Second Renewal Term, (ii) Landlord shall not be required to furnish any materials or perform any work
to prepare the Premises for Tenant’s occupancy and Landlord shall not be required to reimburse Tenant for any Alterations made or to be made by Tenant, and (iii) the Fixed Rent for the Renewal Terms shall be payable at a rate per annum
equal to the “fair market rental value” of the Premises as of the first day of the First Renewal Term in the case of the First Renewal Term, and as of the first day of the Second Renewal Term in the case of the Second Renewal Term. As used
in this Article 43, “fair market rental value” means ninety-five percent (95%) of the Premises’ average market rental value over the six (6) months immediately preceding the applicable Renewal Term. During both
Renewal Terms, all sums of Additional Rent that Tenant is obligated to pay under this Lease during the initial Term shall continue without interruption, it being the intention of the parties hereto that the Renewal Terms shall be deemed a part of
and continuation of the initial Term of this Lease. 
 Section 43.2 If Tenant shall have given the First Renewal Notice or
the Second Renewal Notice, as the case may be, in accordance with Section 43.1 of this Article 43, the parties shall endeavor to agree upon the fair market rental value of the Premises, as of the first day of each Renewal Term. In
determining fair market rental value, the parties shall take into account all relevant factors, including, without limitation, that the Fixed Rent is subject to an automatic two and one half percent (2.5%) annual increase, and the Premises
shall be deemed to have Building standard improvements, notwithstanding that Tenant may have installed above standard improvements. In the event that the parties are unable to agree upon such fair market value for either Renewal Term within thirty
(30) days after the giving of the First Renewal Notice or the Second Renewal Notice as the case may be, then Tenant shall have the right at any time prior to the appointment of a Baseball Arbitrator to void the First Renewal Notice or Second
Renewal Notice, as the case may be, upon notice to Landlord, or if Tenant does not so void such notice then either party may request that the same be determined as follows: A senior officer of a nationally recognized leasing brokerage firm with
local knowledge of Westchester County real estate and knowledge of the greater New York laboratory / research and development leasing market (the “Baseball Arbitrator”) shall be selected and paid for jointly by Landlord and Tenant.
If Landlord and Tenant are unable to agree upon the Baseball Arbitrator, then the same shall be designated by the Manhattan Chapter of the American Arbitration Association or any successor organization thereto (the “AAA”). The
Baseball Arbitrator, but not necessarily his or her employer, selected by the parties or designated by the President of the AAA shall (i) have at least ten years experience in the leasing of office and laboratory / research and development
space in Westchester County and (ii) not have done work for, or been employed or retained by, either Landlord or Tenant or any affiliate of either for a period of at least 10 years prior to his/her appointment pursuant hereto. Landlord and
Tenant shall each submit to the Baseball Arbitrator and to the other its determination of the fair market rental value. The Baseball Arbitrator shall afford to Landlord and Tenant a hearing and the right to submit evidence. The Baseball Arbitrator
shall determine which of the two rent determinations more closely represents the fair market rental value of the Premises. The arbitrator may not select any other fair market rental value for the Premises other than one submitted by Landlord

  
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or Tenant. The determination of the party so selected or designated shall be binding upon Landlord and Tenant and shall serve as the basis for the determination of the Fixed Rent payable for the
applicable Renewal Term. If, as of the commencement date of the applicable Renewal Term, the amount of the Fixed Rent payable during the applicable Renewal Term in accordance with this Article 43 shall not have been determined, then,
pending such determination, Tenant shall pay Fixed Rent equal to the Fixed Rent payable in respect of the last year of the Initial Term in the case of the First Renewal Term and in the last year of the First Renewal Term in the case of the Second
Renewal Term. After the final determination of the Fixed Rent payable for such Renewal Term, the parties promptly and appropriately shall adjust rental payments theretofore made during the applicable Renewal Term and shall execute a written
agreement specifying the amount of the Fixed Rent as so determined. Any failure of the parties to execute such written agreement shall not affect the validity of the Fixed Rent as so determined. 

Section 43.3 It is an express condition of the options granted to Tenant pursuant to the terms of this Article 43 that time
is of the essence with respect to Tenant’s exercise of such options within the periods above provided. 
 ARTICLE 44

 TERMINATION OPTION 
 Tenant shall have the option to terminate this Lease (the “Termination Option”) with respect to the entire Premises effective as of January 1, 2015 (the “Early Termination
Date”), subject to the full satisfaction of the following terms and conditions: (a) Tenant shall provide written notice of the Termination Option no later than July 1, 2014 (the “Termination Notice Deadline”),
time being of the essence; (b) as of the Termination Notice Deadline or the Early Termination Date, Tenant shall not be in default of (i) any monetary obligations or (ii) beyond any applicable notice and cure periods of any of
Tenant’s material non-monetary Lease obligations, and no condition shall exist that with the passage of time or the giving of notice (or both) could mature into a default of any of Tenant’s Lease obligations; (c) any unamortized
brokerage fees or commissions actually paid by Landlord in connection with the representation of Tenant for this Lease shall be reimbursed by Tenant prior to the Early Termination Date (based upon straight-line amortization over the remainder of the
Term remaining after such brokerage commission is paid); (d) any unamortized TI Allowance (based upon straight-line amortization over the 10-year Term) shall be reimbursed by Tenant prior to the Early Termination Date; and (e) Tenant shall
not be released from any provision of this Lease that expressly survives the expiration or earlier termination of this Lease, including without limitation the requirement to surrender the Premises in the condition required under Article 22.

 ARTICLE 45 
 EXPANSION OPTION 
 Section 45.1 Subject to (a) the conditions set
forth in this Article 45, including without limitation, the rights of existing tenants and occupants of the Property, summaries of which may be provided to Tenant upon demand, subject to any confidentiality provisions related thereto, and

  
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(b) the availability of such space, Tenant shall have the right, but not the obligation, to expand the Premises (the “Expansion Option”) to include approximately ten thousand
three hundred ninety (10,390) rentable square feet of contiguous space in Building 777 (the “Expansion Space”) as identified in Schedule E attached hereto. 

Section 45.2 Landlord shall notify Tenant if and when any Expansion Space becomes available (the
“Expansion Notice”). Tenant may exercise the Expansion Option by providing Landlord written notice (the “Expansion Acceptance Notice”). In order for the Expansion Acceptance Notice to be effective it must be given
prior to the date which is the later to occur of (x) sixty (60) days after Landlord’s Expansion Notice and (y) the 777 Premises Commencement Date. Tenant’s failure to timely exercise its Expansion Option shall be deemed a
waiver of Tenant’s Expansion Option and Landlord shall have no further obligation to offer such Expansion Space to Tenant. Within ten (10) days after exercising the Expansion Option, Tenant and Landlord shall enter into a written amendment
to the Lease (the “Amendment”), which amendment shall provide, unless otherwise agreed in writing, (a) the commencement date of the Expansion Space, (b) that the Premises under this Lease shall be increased to include the
rentable square feet of the Expansion Space, (c) the new Fixed Rent, with the Expansion Space increasing Fixed Rent at the then-current rental rate for the 777 Premises per square foot under the Lease, (d) Tenant’s Tax Proportionate
Share and Tenant’s Operating Proportionate Share to exclude the addition of the Expansion Space to the Premises, (e) the increase to the Security Deposit, but only if Landlord has sent two (2) or more notices of monetary default in
any twelve (12) month period prior to the Expansion Notice, and (f) that Landlord has delivered, or is obligated to deliver as a condition to the payment of any Rent with respect to the Expansion Space, such Expansion Space in turn-key
condition similar to the condition that Landlord is required to deliver the 777 Premises pursuant to Exhibit J annexed hereto; provided, however, if the Expansion Option is exercised any time after the first (1st) anniversary of the 777 Premises Commencement Date, the amount
of Landlord’s contribution to the improvement of the Expansion Space shall be reduced on a straight line depreciation schedule (over the remainder of the Term at the time of exercise of the Expansion Option) based on the cost per square foot to
improve the original 777 Premises (e.g., if the initial improvements to the 777 Premises were Ten Dollars ($10) per rentable square foot, then in year two (2) of the Term, Landlord shall only be obligated to provide Nine Dollars ($9) per square
foot of Expansion Space, based on a One Dollar ($1) per year depreciation schedule). Landlord currently estimates that Landlord’s Improvements with respect to the 777 Premises only will cost approximately One Hundred Dollars ($100) per rentable
square foot (provided that Landlord acknowledges that there is no limitation on the amount Landlord is required to spend in order to complete Landlord’s Improvements). In order to make the calculations contemplated by this
Section 45.2, promptly following completion of Landlord’s Improvements, Landlord shall deliver to Tenant as reasonably detailed calculation of Landlord’s actual costs of completing Landlord’s Improvements with respect to
the 777 Premises only. In all other respects, this Lease shall remain in full force and effect, and shall apply to the Expansion Space. 
 Section 45.3 Notwithstanding anything in this Article 45 to the contrary, Tenant shall not exercise the Expansion Option during such period of time that Tenant is in default under any
provision of this Lease. Any attempted exercise of the Expansion Option during a period of time in which Tenant is so in default shall be void and of no effect. In addition, Tenant shall not be entitled to exercise the Expansion Option if Landlord
has given Tenant three (3) or more notices of default under this Lease (provided that any improper notice given by Landlord shall not be counted), whether or not such properly noticed defaults are cured. 

  
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 ARTICLE 46 
 RIGHT OF FIRST OFFER. 
 Section 46.1 Tenant shall have a right of
first offer (“ROFO”) as to any rentable premises in the Buildings contiguous (including adjacent floors) to the Premises for which Landlord is seeking a tenant (“Available ROFO Premises”); provided, however, that in
no event shall Landlord be required to lease any Available ROFO Premises to Tenant for any period past the date on which this Lease expires or is terminated pursuant to its terms. To the extent that Landlord renews or extends a then-existing lease
with any then-existing tenant of any space, or enters into a new lease or an amendment with such then-existing tenant for the affected space, such space shall not be deemed to be Available ROFO Premises. In the event Landlord intends to market
Available ROFO Premises, Landlord shall provide written notice thereof to Tenant (the “Notice of Marketing”). 

Section 46.2 Within ten (10) Business Days following its receipt of a Notice of Marketing, Tenant shall advise Landlord in
writing whether Tenant elects to lease all (not just a portion) of the Available ROFO Premises and on what terms and conditions. If Tenant fails to notify Landlord of Tenant’s election within said ten (10) Business Day period, then Tenant
shall be deemed to have elected not to lease the Available ROFO Premises. 
 Section 46.3 If Tenant timely notifies
Landlord that Tenant elects to lease all of the Available ROFO Premises and of the terms and conditions therefore (“Tenant’s Offer”) (provided that Tenant shall be required to lease the Available ROFO Premises for at least the
remainder of the then-current Term), then Landlord shall have ten (10) days after receipt of Tenant’s Offer to respond to Tenant in writing whether Landlord elects to lease the Available ROFO Premises to Tenant on the terms and conditions
set forth in Tenant’s Offer. 
 Section 46.4 If (a) Tenant notifies Landlord that Tenant elects not to lease the
Available ROFO Premises, (b) Tenant fails to notify Landlord of Tenant’s election within the ten (10)-day period described above or (c) Landlord declines to lease the Available ROFO Premises to Tenant on the terms and conditions set
forth in Tenant’s Offer, then Landlord shall have the right to consummate a lease of the Available ROFO Premises at base rent not less than that stated in Tenant’s Offer, unless such base rent is first offered to Tenant first in accordance
with the terms of this Article 46. 
 Section 46.5 Notwithstanding anything in this Article 46 to the
contrary, Tenant shall not exercise the ROFO during such period of time that Tenant is in default of (i) any monetary obligations or (ii) beyond any applicable notice and cure periods of any of Tenant’s material non-monetary Lease
obligations. Any attempted exercise of the ROFO during a period of time in which Tenant is so in default shall be void and of no effect. In addition, Tenant shall not be entitled to exercise the ROFO if Landlord has given Tenant two (2) or more
notices of default under this Lease in any twelve (12) month period during the Term (provided that any improper notice given by Landlord shall not be counted), whether or not such properly noticed defaults are cured. 

  
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 Section 46.6 Notwithstanding anything in this Lease to the contrary, Tenant shall not
assign or transfer the ROFO, either separately or in conjunction with an assignment or transfer of Tenant’s interest in the Lease, without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute
discretion. 
 Section 46.7 If Tenant exercises the ROFO, Landlord does not guarantee that the Available ROFO Premises will
be available on the anticipated commencement date for the Lease as to such Premises due to a holdover by the then-existing occupants of the Available ROFO Premises or for any other reason beyond Landlord’s reasonable control. 

ARTICLE 47 
 ATON
SUBLEASE 
 Section 47.1 Promptly after the Execution Date, at no cost to Tenant, Aton and Tenant shall terminate the Aton
Sublease and Landlord shall enter into an agreement with Aton to terminate that portion of the lease between Landlord and Aton for the Aton Subleased Premises, each termination to be effective as of the 777 Premises Commencement Date. Tenant shall
cooperate with Landlord in the termination of the Aton Sublease as aforesaid. If for any reason the Aton Sublease is not terminated on the 777 Premises Commencement Date, provided that (a) Tenant shall not be in default of (i) any monetary
obligations, or (ii) beyond any applicable notice and cure periods of any of Tenant’s material non-monetary Lease obligations, and (b) Tenant has vacated the Aton Subleased Premises and takes delivery of the 777 Premises, then
Landlord hereby assumes all of Tenant’s obligations under the Aton Sublease, effective as of 777 Premises Commencement Date. 
 SIGNATURES ON NEXT PAGE 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Lease as of the day and year
first above written. 
  

					
	BMR-LANDMARK AT EASTVIEW LLC,
Landlord
		
	By:	 	 /s/ Kent Griffin

		 	Name:	 	Kent Griffin
		 	Title:	 	President and C.F.O.
	
	PROGENICS PHARMACEUTICALS, INC.,
Tenant
		
	By:	 	 /s/ Robert A. McKinney

		 	Name:	 	Robert A. McKinney
		 	Title:	 	 CFO and Senior Vice President

Finance and Operations

  
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 FIRST AMENDMENT TO AMENDED AND RESTATED AGREEMENT OF LEASE 

THIS FIRST AMENDMENT TO AMENDED AND RESTATED AGREEMENT OF LEASE (this “Amendment”) is entered into
as of this 1st day of June, 2010, by and between BMR-
LANDMARK AT EASTVIEW LLC, a Delaware limited liability company (“Landlord”), and PROGENICS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A. WHEREAS, Landlord (as successor-in-interest to Eastview Holdings LLC) and Tenant entered into that certain Agreement of Lease dated as of September 23, 2003, as amended by that certain First
Amendment of Lease dated as of May 17, 2004, that certain Second Amendment of Lease (Partial Termination Agreement) dated as of March 1, 2005, that certain Third Amendment to Agreement of Lease dated as of March 15, 2006, that certain
Fourth Amendment to Agreement of Lease dated as of August 9, 2007, that certain Fifth Amendment to Agreement of Lease dated as of November 30, 2007, and that certain Sixth Amendment to Agreement of Lease dated as of May 12, 2009
(collectively, the “Original Lease”), whereby Tenant leased the Original Premises from Landlord; 
 B. WHEREAS,
Landlord and Tenant entered into that certain Amended and Restated Agreement of Lease dated as of October 28, 2009 (as the same may have been further amended, amended and restated, supplemented or otherwise modified from time to time, the
“Amended and Restated Lease”), which amends and restates the Original Lease in its entirety, whereby Tenant leases certain premises (the “Premises”) from Landlord in the 769 Building, the 771 Building and the 777
Building; provided, however, that Tenant continues to occupy portions of the Original Premises (as defined in the Amendment and Restated Lease) pursuant to the terms of the Amended and Restated Lease at the Rental set forth in the Original
Lease; 
 C. WHEREAS, Tenant desires to surrender a portion of the Original Premises (i.e. the Old 777 Premises) to Landlord;
and 
 D. WHEREAS, Landlord and Tenant desire to modify and amend the Amended and Restated Lease only in the respects and on the
conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions. For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Amended and Restated Lease unless otherwise defined herein. 

2. Surrender of Premises. Tenant surrendered to Landlord prior to 11:59 p.m. on May 31, 2010 (the “Surrender
Date”), the Old 777 Premises, as depicted on Exhibit A attached hereto (the “Surrendered Premises”), in the condition required by Section 2.6 and Article 22 of the Amended

  
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dated 8/21/09 

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and Restated Lease; provided that, notwithstanding anything to the contrary in the Amended and Restated Lease, Tenant did not have the obligation to remove any Alterations. Landlord
acknowledges that Tenant has surrendered the Surrendered Premises as and when required by this Section 2. 
 3.
Proportionate Share. From and after the Surrender Date, Tenant continues to occupy the Old 765 Premises pursuant to Section 2.6 of the Amended and Restated Lease. Notwithstanding anything in the Amended and Restated Lease to the
contrary, commencing on the Surrender Date, Tenant’s Tax Proportionate Share and Tenant’s Operating Proportionate Share with respect to the portion of the Original Premises which Tenant continues to occupy shall each equal two and thirty-
nine hundredths percent (2.39%). For purposes of clarity, (i) Tenant’s Tax Proportionate Share and Tenant’s Operating Proportionate Share with respect to the Premises as set forth in Items 14 and 15 of the Reference Page
of the Amended and Restated Lease shall not change and (ii) the Aton Subleased Premises, which Tenant continues to occupy pursuant to Section 2.6 of the Amended and Restated Lease, is not part of the Original Premises. 

4. Fixed Rent for Surrendered Premises. Commencing on the Surrender Date, Tenant’ s obligation to pay Fixed Rent with respect
to the Surrendered Premises shall cease (except for any unpaid balance) and, to the extent Tenant has paid Fixed Rent and Additional Rent for June, 2010, in advance, Tenant shall receive a credit in the amount of the Fixed Rent, Tenant’s Tax
Payment and Tenant’s Operating Payment with respect to the period after the Surrender Date against Fixed Rent next becoming due. 
 5. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Landlord
harmless from any and all cost or liability for compensation claimed by any broker or agent employed or engaged by Tenant or claiming to have been employed or engaged by Tenant. Landlord represents and warrants that it has not dealt with any broker
or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Tenant harmless from any and all cost or liability for compensation claimed by any broker or agent employed or engaged by Landlord or
claiming to have been employed or engaged by Landlord. 
 6. No Default. Tenant represents, warrants and covenants that,
to the best of Tenant’s knowledge, Landlord and Tenant are not in default of any of their respective obligations under the Amended and Restated Lease and no event has occurred that, with the passage of time or the giving of notice (or both)
would constitute a default by either Landlord or Tenant thereunder. 
 7. Effect of Amendment. Except as modified by this
Amendment, the Amended and Restated Lease and all the covenants, agreements, terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and
conditions contained in this Amendment shall bind and inure to the benefit of the parties hereto and their respective successors and, except as otherwise provided in the Amended and Restated Lease, their respective assigns. In the event of any
conflict between the terms contained in this Amendment and the Amended and Restated Lease, the terms herein contained shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term
“Lease” as used in the Amended and Restated Lease shall mean the Amended and Restated Lease, as modified by this Amendment. 

  
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 8. Miscellaneous. This Amendment becomes effective only upon execution and delivery
hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits
hereto are incorporated herein by reference. 
 9. Counterparts. This Amendment may be executed in one or more
counterparts that, when taken together, shall constitute one original. 
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 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and
year first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Amendment. 
  

			
	LANDLORD:
	
	 BMR-LANDMARK AT EASTVIEW LLC,
 a Delaware limited liability company

		
	By:	 	 /s/ Kevin M. Simonsen

	Name:	 	 Kevin M. Simonsen

	Title:	 	 VP, Real Estate Counsel

	
	TENANT:
	
	 PROGENICS PHARMACEUTICALS, INC.,
 a Delaware corporation

		
	By:	 	 /s/ Robert A. McKinney

	Name:	 	 ROBERT A. MCKINNEY

	Title:	 	 CFO

Table of Contents

 SECOND AMENDMENT TO AMENDED AND RESTATED AGREEMENT OF LEASE 

THIS SECOND AMENDMENT TO AMENDED AND RESTATED AGREEMENT OF LEASE (this “Amendment”) is entered into
as of this 19th day of November, 2010, by and between
BMR-LANDMARK AT EASTVIEW LLC, a Delaware limited liability company (“Landlord”), and PROGENICS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A. WHEREAS, Landlord (as successor-in-interest to Eastview Holdings LLC) and Tenant entered into that certain Agreement of Lease dated as of September 23, 2003, as amended by that certain First
Amendment of Lease dated as of May 17, 2004, that certain Second Amendment of Lease (Partial Termination Agreement) dated as of March 1, 2005, that certain Third Amendment to Agreement of Lease dated as of March 15, 2006, that certain
Fourth Amendment to Agreement of Lease dated as of August 9, 2007, that certain Fifth Amendment to Agreement of Lease dated as of November 30, 2007, and that certain Sixth Amendment to Agreement of Lease dated as of May 12, 2009
(collectively, the “Original Lease”), whereby Tenant leased the Original Premises from Landlord; 
 B. WHEREAS,
Landlord and Tenant entered into that certain Amended and Restated Agreement of Lease dated as of October 28, 2009, as amended by that certain First Amendment to Amended and Restated Agreement of Lease dated as of June 1, 2010 (as the same
may have been further amended, amended and restated, supplemented or otherwise modified from time to time, the “Restated Lease”), which amends and restates the Original Lease in its entirety, whereby Tenant leases certain premises
(the “Premises”) from Landlord in the 769 Building, the 771 Building and the 777 Building; provided, however, that Tenant continues to occupy portions of the Original Premises (as defined in the Restated Lease) pursuant to
the terms of the Restated Lease at the Rental set forth in the Original Lease; 
 C. WHEREAS, Tenant desires to surrender a
portion of the Old 765 Premises to Landlord; and 
 D. WHEREAS, Landlord and Tenant desire to modify and amend the Restated
Lease only in the respects and on the conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions. For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Restated Lease unless otherwise defined herein. 

2. Surrender of Premises. Tenant shall surrender to Landlord prior to 11:59 p.m. on May 31, 2010 (the “Surrender
Date”), a portion of the Old 765 Premises containing approximately 

  
 BMR form
dated 9/23/10 

Table of Contents

 
four thousand seventy (4,070) rentable square feet, as depicted on Exhibit A attached hereto (the “Surrendered Premises”), in the condition required by
Section 2.6 and Article 22 of the Restated Lease; provided that, notwithstanding anything contained in the Restated Lease to the contrary, Tenant does not have the obligation to remove any Alterations. 

3. Proportionate Share. From and after the Surrender Date, Tenant continues to occupy the remainder of the Old 765 Premises
pursuant to the Restated Lease, as modified by this Amendment. Notwithstanding anything in the Restated Lease to the contrary, commencing on the Surrender Date, Tenant’s Tax Proportionate Share and Tenant’s Operating Proportionate Share
with respect to the portion of the Original Premises that Tenant shall continue to occupy shall each equal one and eighty-five hundredths percent (1.85%). For purposes of clarity, (a) Tenant’s Tax Proportionate Share and Tenant’s
Operating Proportionate Share with respect to the Premises as set forth in Items 14 and 15 of the Reference Page of the Restated Lease shall not change and (b) the Aton Subleased Premises, which Tenant continues to occupy pursuant
to Section 2.6 of the Restated Lease, is not part of the Original Premises. 
 4. Fixed Rent for Surrendered
Premises. Commencing on the Surrender Date, Tenant’s obligation to pay Fixed Rent with respect to the Surrendered Premises shall cease (except for any unpaid balance) and, to the extent Tenant has paid Fixed Rent, Operating Expenses or
Taxes with respect to the surrendered Premises for June 2010 and subsequent months, Tenant shall receive a credit against Fixed Rent next becoming due in the amount of Fixed Rent, Operating Expenses or Taxes paid with respect to the Surrendered
Premises for the period after the Surrender Date. 
 5. Broker. Tenant represents and warrants that it has not dealt with
any broker or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by
Tenant or claiming to have been employed or engaged by Tenant. Landlord represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Tenant
harmless from any and all cost or liability for compensation claimed by any broker or agent employed or engaged by Landlord or claiming to have been employed or engaged by Landlord. 

6. No Default. Tenant represents, warrants and covenants that, to the best of Tenant’s knowledge, Landlord and Tenant are not
in default of any of their respective obligations under the Restated Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. 

7. Effect of Amendment. Except as modified by this Amendment, the Restated Lease and all the covenants, agreements, terms,
provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Amendment shall bind and inure to the benefit of the parties
hereto and their respective successors and, except as otherwise provided in the Restated Lease, their respective assigns. In the event of any conflict between the terms contained in this Amendment and the Restated Lease, the terms herein contained
shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Restated Lease shall mean the Restated Lease, as modified by this Amendment. 

  
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 8. Miscellaneous. This Amendment becomes effective only upon execution and delivery
hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits
hereto are incorporated herein by reference. 
 9. Counterparts. This Amendment may be executed in one or more
counterparts, each of which, when taken together, shall constitute one and the same document. 
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INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and
year first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Amendment. 
  

			
	LANDLORD:
	
	 BMR-LANDMARK AT EASTVIEW LLC,
 a Delaware limited liability company

		
	By:	 	 /s/ Kevin M. Simonsen

	Name:	 	 Kevin M. Simonsen

	Title:	 	 VP, Real Estate Counsel

	
	TENANT:
	
	 PROGENICS PHARMACEUTICALS, INC.,
 a Delaware corporation

		
	By:	 	 /s/ Robert A. McKinney

	Name:	 	 ROBERT A. MCKINNEY

	Title:	 	 CFO

Table of Contents

 THIRD AMENDMENT TO AMENDED AND RESTATED LEASE 

THIS THIRD AMENDMENT TO AMENDED AND RESTATED LEASE (this “Amendment”) is entered into as of this
23rd day of January, 2012 (the “Execution
Date”), by and between BMR-LANDMARK AT EASTVIEW LLC, a Delaware limited liability company (“Landlord”), and PROGENICS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A. WHEREAS, Landlord (as successor-in-interest to Eastview Holdings LLC) and Tenant entered into that certain Agreement of Lease dated as of September 30, 2003, as amended by that certain First
Amendment of Lease dated as of May 17, 2004, that certain Second Amendment of Lease (Partial Termination Agreement) dated as of March 1, 2005, that certain Third Amendment to Agreement of Lease dated as of March 15, 2006, that certain
Fourth Amendment to Agreement of Lease dated as of August 9, 2007, that certain Fifth Amendment to Agreement of Lease dated as of November 30, 2007, and that certain Sixth Amendment to Agreement of Lease dated as of May 12, 2009
(collectively, the “Original Lease”), whereby Tenant leased certain premises from Landlord; 
 B. WHEREAS,
Landlord and Tenant entered into that certain Amended and Restated Agreement of Lease dated as of October 28, 2009, as amended by that certain First Amendment to Amended and Restated Agreement of Lease dated as of June 1, 2010, and that
certain Second Amendment to Amended and Restated Agreement of Lease dated as of November 19, 2010 (collectively, and as the same may have been further amended, amended and restated, supplemented or otherwise modified from time to time, the
“Restated Lease”), which amends and restates the Original Lease in its entirety, and whereby Tenant leases certain premises (the “Premises”) from Landlord at 765, 769, 771 and 777 Old Saw Mill River Road, Tarrytown,
New York (the “765 Building,” the “769 Building,” the “771 Building” and the “777 Building,” respectively); 
 C. WHEREAS, the Premises currently consist of a total of one hundred twenty-nine thousand six hundred ninety-seven (129,697) square feet of rentable area, comprised of the following spaces:

 (i) the “Old 765 Premises,” containing a total of approximately thirteen thousand nine hundred seven
(13,907) square feet of rentable area in the 765 Building, as shown on Exhibit A attached hereto, consisting of (a) a portion of the mezzanine level of the 765 Building containing approximately five thousand one hundred forty
(5,140) square feet of rentable area, (b) a portion of the mezzanine level of the 765 Building containing approximately seven thousand two hundred twenty-two (7,222) square feet of rentable area, and (c) a portion of the
mezzanine level of the 765 Building containing approximately one thousand five hundred forty-five (1,545) square feet of rentable area; 
 (ii) the “769 Premises,” containing a total of approximately forty-two thousand eight hundred ninety-six (42,896) square feet of rentable area in the 769 Building, as shown on
Exhibit B attached hereto, located on (a) the fourth floor of the 769 Building, 

  
 BMR form
dated 10/12/11 

Table of Contents

 
containing approximately twenty-four thousand eight hundred seventy-five (24,875) square feet of rentable area (the “769 Fourth Floor Premises”), (b) a portion of the
third floor of the 769 Building containing approximately fifteen thousand five hundred twenty-five (15,525) square feet of rentable area (the “769 Third Floor Premises” ) and (c) a portion of the first floor of the 769
Building containing approximately two thousand four hundred ninety-six (2,496) square feet of rentable area (the “769 First Floor Premises”); and 
 (iii) the “771 Premises,” containing a total of approximately seventy-two thousand eight hundred ninety-four (72,894) square feet of rentable area in the 771 Building, as shown on
Exhibit C attached hereto, located on (a) the first floor of the 771 Building, containing approximately fifty-two thousand four hundred twenty (52,420) square feet of rentable area (the “771 First Floor Premises”),
and (b) the lower level of the 771 Building, containing approximately twenty thousand four hundred seventy-four (20,474) square feet of rentable area (the “771 Lower Level Premises”); 

D. WHEREAS, Tenant occupies a portion of the 765 Building, as shown on Exhibit D attached hereto (the “Aton Subleased
Premises”), pursuant to that certain Sublease Agreement dated as of March 20, 2006 (as the same may have been amended, amended and restated, supplemented or otherwise modified from time to time, the “Aton Sublease”),
by and between Tenant (as subtenant) and Aton Pharma, Inc. (“Aton,” as sublandlord), which Aton Subleased Premises Tenant intended to lease directly from Landlord; 

E. WHEREAS, Tenant intended to lease from Landlord and Landlord intended to lease to Tenant a portion of the second floor of the 777
Building as shown on Exhibit E attached hereto (the “777 Undelivered Premises”) containing approximately thirty-three thousand five hundred twenty-six (33,526) square feet of rentable area. The 777 Undelivered Premises,
however, have not yet been delivered to Tenant and the Term with respect to the 777 Undelivered Premises has not yet commenced; 

F. WHEREAS, Tenant desires to surrender the Old 765 Premises and the 769 Premises to Landlord (the “Surrender
Premises”); 
 G. WHEREAS, Tenant no longer desires to directly lease the Aton Subleased Premises from Landlord;

 H. WHEREAS, Tenant desires to lease from Landlord and Landlord desires to lease to Tenant certain replacement premises
consisting of approximately nineteen thousand one hundred twenty-five (19,125) square feet of rentable area located on the lobby level of the 777 Building, as shown on Exhibit F attached hereto (the “Substitute 777
Premises”); and 
 I. WHEREAS, Landlord and Tenant desire to modify and amend the Restated Lease only in the respects
and on the conditions hereinafter stated. 

  
 2 

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 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions. For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Restated Lease unless otherwise defined herein. 

2. Lease of Substitute 777 Premises. Landlord hereby leases to Tenant and Tenant hereby leases from Landlord the Substitute 777
Premises as of the Substitute 777 Premises Commencement Date (as defined below) for use by Tenant in accordance with the Permitted Use and the other terms and conditions of the Restated Lease. From and after the Substitute 777 Premises Commencement
Date, the “Premises,” as defined in the Restated Lease, shall include the Substitute 777 Premises. 
 3.
Substitute 777 Premises Commencement Date. The Term with respect to the Substitute 777 Premises shall commence on the Execution Date (the “Substitute 777 Premises Commencement Date”), and shall terminate, subject to any
extension options granted pursuant to the Restated Lease, upon the Fixed Expiration Date (as defined in the Restated Lease). 

4. 771 Premises. Tenant shall continue to lease the 771 Premises until the Fixed Expiration Date (as defined in the Restated
Lease). 
 5. Surrender of the Old 765 Premises and the 769 Third Floor Premises. 

(a) Tenant surrendered to Landlord prior to 11:59 p.m. on December 31, 2011 (the “Phase 1 Surrender Date”), the Old
765 Premises and the 769 Third Floor Premises (i) with the Alterations listed on Exhibit G attached hereto removed (including the repair of all damage to the Buildings or the Premises caused thereby) and (ii) in the condition
required by Article 22 of the Restated Lease. With respect to the Old 765 Premises and the 769 Third Floor Premises, Tenant shall have until January 13, 2012, to comply with the decommissioning requirements set forth in
Section 18 below that are incorporated into the Restated Lease pursuant to this Amendment (and, for the sake of clarity, the requirement in Section 18 below that such decommissioning requirements must be performed ten
(10) days prior to Tenant’s surrender shall not apply to Tenant’s surrender of the Old 765 Premises and the 769 Third Floor Premises); provided that, notwithstanding anything contained in the Restated Lease to the contrary,
Tenant shall not have the obligation to remove any Alterations in the Old 765 Premises and the 769 Third Floor Premises that are not listed on Exhibit G attached hereto. 

(b) Commencing on the day immediately following the Phase 1 Surrender Date, Tenant’s obligation to pay Fixed Rent, Operating
Expenses, Taxes and any other expenses with respect to the Old 765 Premises and the 769 Third Floor Premises shall cease (except for any unpaid balance and Landlord’s rights under the Restated Lease to reconcile Operating Expenses, Taxes and
other expenses) and, to the extent Tenant has paid Fixed Rent, Operating Expenses or Taxes with respect to the surrendered Old 765 Premises or 769 Third Floor Premises for January 2012 and subsequent months, Tenant shall receive a credit against
Fixed 

  
 3 

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Rent next becoming due in the amount of Fixed Rent, Operating Expenses or Taxes paid with respect to the Old 765 Premises and 769 Third Floor Premises for the period after the Phase 1 Surrender
Date. 
 (c) Commencing on the day immediately following the Phase 1 Surrender Date, the “Premises,” as defined in the
Restated Lease, shall no longer include the Old 765 Premises or the 769 Third Floor Premises. 
 6. Surrender of the 769
First Floor Premises and the 769 Fourth Floor Premises. 
 (a) Tenant shall surrender to Landlord prior to 11:59 p.m. on
March 31, 2012 (the “Phase 2 Surrender Date”), the 769 First Floor Premises and the 769 Fourth Floor Premises (i) with the Alterations listed on Exhibit G attached hereto removed (including the repair of all damage to
the Buildings or the Premises caused thereby) or decommissioned and left in place as set forth on Exhibit G, (ii) in the condition required by Article 22 of the Restated Lease and (iii) in accordance with the decommissioning
requirements set forth in Section 18 below that are incorporated into the Restated Lease pursuant to this Amendment; provided that, notwithstanding anything contained in the Restated Lease to the contrary, Tenant shall not have
the obligation to remove any Alterations in the 769 First Floor Premises and the 769 Fourth Floor Premises that are not listed to be removed on Exhibit G attached hereto. 

(b) Commencing on the day immediately following the Phase 2 Surrender Date, Tenant’s obligation to pay Fixed Rent, Operating
Expenses, Taxes and any other expenses with respect to the 769 First Floor Premises and to the 769 Fourth Floor Premises shall cease (except for any unpaid balance and Landlord’s rights under the Restated Lease to reconcile Operating Expenses,
Taxes and other expenses) and, to the extent Tenant has paid Fixed Rent, Operating Expenses or Taxes with respect to the surrendered 769 First Floor Premises or the 769 Fourth Floor Premises for April 2012 and subsequent months, Tenant shall receive
a credit against Fixed Rent next becoming due in the amount of Fixed Rent, Operating Expenses or Taxes paid with respect to the 769 First Floor Premises and 769 Fourth Floor Premises for the period after the Phase 2 Surrender Date. 

(c) Commencing on the day immediately following the Phase 2 Surrender Date, the “Premises,” as defined in the Restated Lease,
shall no longer include the 769 First Floor Premises or the 769 Fourth Floor Premises. 
 7. 777 Undelivered Premises.
The parties acknowledge that Tenant has never taken possession of the 777 Undelivered Premises, which were leased to Tenant pursuant to the Restated Lease. The “Premises,” as defined in the Restated Lease, have never and shall never
include the 777 Undelivered Premises. Tenant shall have no obligation to (a) pay Fixed Rent, Operating Expenses, Taxes and any other expenses with respect to the 777 Undelivered Premises or (b) lease the 777 Undelivered Premises from
Landlord pursuant to the Restated Lease. 
 8. Aton Subleased Premises. 

(a) The parties acknowledge that Tenant currently subleases the Aton Subleased Premises from Aton. The term under the Aton Sublease with
respect to the Aton 

  
 4 

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Subleased Premises expires on June 29, 2012 (“Aton Premises Surrender Date”). Tenant acknowledges, however, that it is proposing to surrender the Aton Subleased Premises to
Aton prior to such date. 
 (b) Pursuant to both the Original Lease and the Restated Lease, Tenant intended to directly lease
from Landlord and Landlord intended to directly lease to Tenant the Aton Subleased Premises. Because, however, Tenant no longer desires to directly lease from Landlord and Landlord no longer desires to directly lease to Tenant the Aton Sublease
Premises, the “Premises,” as defined in the Restated Lease (and the Original Lease), have never and shall never include the Aton Subleased Premises. 
 (c) Provided that Tenant surrenders the Aton Subleased Premises prior to 11:59 p.m. on the Aton Subleased Premises Surrender Date (pursuant to the terms of the Aton Sublease), Tenant shall have no
obligation to (i) pay Fixed Rent, Operating Expenses, Taxes or any other expenses directly to Landlord with respect to the Aton Subleased Premises or (ii) lease the Aton Subleased Premises directly from Landlord pursuant to either the
Original Lease or the Restated Lease. 
 9. Fixed Rent. As of January 1, 2012, Schedule I attached to the
Restated Lease shall be deleted in its entirety and replaced with Schedule I attached hereto. 
 10. NNN Payment.
Tenant’s obligation to pay Tenant’s Operating Payment, Tenant’s Tax Payment, HVAC Electric payment and Basic Electric payment (collectively, and all as defined in the Restated Lease, the “NNN Expenses”) with respect
to the Premises shall be as set forth below: 
 (a) Notwithstanding anything to the contrary contained in the Restated Lease,
commencing on April 1, 2012, and continuing through December 31, 2014, Tenant’s NNN Expenses with respect to the Substitute 777 Premises shall be fixed at $25.50 per rentable square foot annually (“Fixed 777 NNN
Payment”). Commencing on January 1, 2015, Tenant shall pay the greater of (i) the Fixed 777 NNN Payment and (ii) the actual NNN Expenses with respect to the Substitute 777 Premises, calculated pursuant to the terms of the
Restated Lease. 
 (b) Notwithstanding anything to the contrary contained in the Restated Lease, commencing on January 1,
2012, and continuing through December 31, 2014, Tenant’s NNN Expenses with respect to the 771 Premises shall be $29.00 per square foot annually (“Fixed 771 NNN Payment”). Commencing on January 1, 2015, Tenant shall
pay the greater of (i) the Fixed 771 NNN Payment and (ii) the actual NNN Expenses with respect to the 771 Premises, calculated pursuant to the terms of the Restated Lease. 

(c) In order to effectuate Subsections 10(a) and 10(b), and notwithstanding anything to the contrary contained in the
Restated Lease, the charges for the NNN Expenses shall at all times be calculated and determined separately for each of (i) the Substitute 777 Premises, (ii) the 771 Premises and (iii) any other premises that may be separately added to the
Premises from time to time. 
 (d) Tenant shall continue to pay NNN Expenses with respect to the 769 First Floor Premises and
the 769 Fourth Floor Premises in accordance with the terms of the Restated Lease until the Phase 2 Surrender Date. 

  
 5 

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 11. Tenant’s New Proportionate Share: Tenant’s Tax Proportionate Share (as
defined in Item 14 of the Reference Page of the Restated Lease) and Tenant’s Operating Proportionate Share (as defined in Item 15 of the Reference Page of the Restated Lease) shall be modified as follows on the day
immediately following the surrender dates set forth below: 
  

											
	 As of the day immediately following
	  	Core
Campus	 	 	Existing
Campus	 
	 Phase 1 Surrender Date*
	  	769 Building	  	 	2.30	% 	 	 	3.31	% 
	  	771 Building	  	 	6.13	% 	 	 	8.81	% 
	  	777 Building	  	 	1.61	% 	 	 	2.31	% 
	  	Premises Total	  	 	10.04	% 	 	 	14.43	% 
	 Phase 2 Surrender Date
	  	771 Building	  	 	6.13	% 	 	 	8.81	% 
	  	777 Building	  	 	1.61	% 	 	 	2.31	% 
	  	Premises Total	  	 	7.74	% 	 	 	11.12	% 

  

	*	Assuming a timely surrender, the day immediately following the Phase 1 Surrender Date would be the same day as the Substitute 777 Premises Commencement Date.

 12. Restrooms. Tenant shall have the non-exclusive right with Landlord, other tenants and other persons
to use the men’s and women’s restrooms adjacent to the Substitute 777 Premises (the “Restrooms”) twenty-four (24) hours a day, seven (7) days a week. The Restrooms shall be cleaned and maintained in accordance
with Schedule D to the Restated Lease. 
 13. 771 Lower Level Landlord Work. Landlord shall, at Landlord’s
sole cost and expense (which shall not constitute an Operating Expense) and in accordance with Landlord’s design and specifications, (a) if needed, apply a sealant and/or waterproofing materials to the perimeter of the 771 Lower Level
Premises and take any other commercially reasonable efforts necessary to mitigate water intrusion and (b) install backwater valves in the existing main sewer lines serving the basement of the 771 Building. All of the work required of Landlord
pursuant to this Section 13 shall be completed prior to December 31, 2012. 
 14. Original Lease. From
and after the Phase 1 Surrender Date, the Original Lease shall terminate in its entirety and be of no further force and effect (except for those obligations that expressly survive the expiration or earlier termination of the Original Lease);
provided that, notwithstanding anything to the contrary contained in the Restated Lease, any deficiency, overpayment or other adjustment with regard to the estimated payments of all NNN Expenses for the premises being surrendered on the Phase
1 Surrender Date paid through December 31, 2011 (“2011 NNN Expenses”) pursuant to the Restated Lease and/or the Original Lease, shall be reconciled by June 1, 2012 (the “2011 Reconciliation Date”), and
each of Landlord and Tenant waive its right to recovery of the 2011 NNN Expenses after the 2011 Reconciliation Date. 

  
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 15. Deletions from and Other Revisions to Restated Lease. 

(a) Sections 2.4, 2.6, 2.7, 3.11, 4.10 and 23.2; Articles 45 and 47 and
Schedule E of the Restated Lease are hereby deleted in their entirety and are of no further force or effect. 
 (b) The
phrase “(excluding the 777 Premises)” appearing in Sections 3.6, 3.7, 4.7 and 4.9 of the Restated Lease is hereby deleted and of no further force or effect. 

(c) Section 23.1 of the Restated Lease is hereby deleted in its entirety and replaced with the following: 

Section 23.1 If Landlord shall be unable to deliver possession of any additional space to be included within the Premises other than
the 777 Substitute Premises on the specific date (if any) designated in this Lease for the commencement of the Term or for the inclusion of such space for any reason whatsoever, Landlord shall not be subject to any liability therefor and the
validity of this Lease shall not be impaired thereby, but the applicable commencement date shall be postponed until three (3) Business Days after notice from Landlord that the Premises or such additional space are available for occupancy by
Tenant. Tenant expressly waives any other right to rescind this Lease under Section 223-a of the New York Real Property Law or under any present or future statute of similar import then in force, and further expressly waives the right to
recover any damages that may result from Landlord’s failure to deliver possession of the Premises or such additional space on the specific date (if any) designated for the commencement of the Term. Tenant agrees that the provisions of this
Article 23 are intended to constitute “an express provision to the contrary” within the meaning of such Section 223-a. 
 (d) The phrase “Except with respect to the 777 Premises” appearing in the last sentence of Section 30.1 of the Restated Lease is hereby deleted in its entirety and is of no further
force or effect. 
 (e) The phrase “Landlord Improvements to 777 Premises” and the Section entitled “Building
777” on Schedule J are hereby deleted in their entirety and are of no further force or effect. 
 16.
Parking. 
 (a) Item 19 of the Reference Page of the Restated Lease is hereby deleted in its entirety and
replaced with the following: 
 “Tenant’s pro rata share (based on the entire Premises) of unreserved parking
spaces.” 

  
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 (b) Section 34.1 of the Restated Lease is hereby deleted in its entirety and
replaced with the following: 
 Section 34.1 Landlord shall, without charge to Tenant (except as a consequence of the cost
thereof being included in Operating Expenses), provide and maintain, for the nonexclusive use of Tenant’s employees and invitees, parking areas sufficient to accommodate that number of standard size automobiles as shall be equal to the Number
of Parking Spaces set forth in the Reference Page. 
 (c) Schedule H to the Restated Lease is hereby deleted in its
entirety and is of no further force or effect. 
 17. Asbestos. With respect to the representation made by Landlord in
Section 9.8 of the Restated Lease, to Landlord’s actual knowledge, there is no asbestos in the Premises or the public areas of the Buildings, except for asbestos that is either encapsulated or is not in friable condition.

 18. Decommissioning Requirements. A new Section 22.6 is hereby added to Article 22 of the Restated
Lease as follows: 
 Section 22.6 At least ten (10) days prior to Tenant’s surrender of possession of any part of
the Premises, Tenant shall provide Landlord with (a) a facility decommissioning and Hazardous Materials closure plan for the Premises (“Exit Survey”) prepared by Katt Consulting (Bill Katt, principal) or another independent
third party reasonably acceptable to Landlord, (b) written evidence of all appropriate governmental releases obtained by Tenant in accordance with all Requirements, including laws pertaining to the surrender of the Premises, and
(c) written evidence or confirmation from Katt Consulting or another independent third party reasonably acceptable to Landlord that the Premises have been decommissioned in accordance with American National Standards Institute
(“ANSI”) Publication Z9.11-2008 (entitled “Laboratory Decommissioning”) or any successor standards published by ANSI or any successor organization (or, if ANSI and its successors no longer exist, a similar entity
publishing similar standards). In addition, Tenant agrees to remain responsible after the surrender of the Premises for the remediation of any recognized environmental conditions (excluding those environmental conditions for which Landlord is
responsible pursuant to the terms of the Restated Lease) set forth 

  
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in the Exit Survey and compliance with any recommendations set forth in the Exit Survey. Tenant’s obligations under this subsection shall survive the expiration or earlier termination of the
Lease. 
 19. TI Allowance. The parties acknowledge that, with respect to Article 23 of the Restated Lease, Tenant
has expended One Million One Hundred Fifty-Three Thousand Nine Hundred Sixty-Eight and 56/100 Dollars ($1,153,968.56) of the TI Allowance. Landlord has no further obligation to fund any remaining balance of the TI Allowance. 

20. Termination Option. For purposes of clarity, the Termination Option granted to Tenant in Article 44 of the Restated
Lease shall apply to the entire Premises, as the same has been modified (either surrendered or leased) pursuant to this Amendment; provided, however, that the 769 Premises shall be included in calculating any unamortized brokerage fees or
commissions actually paid by Landlord and any unamortized TI Allowance pursuant to Subsections (c) and (d) of Article 44, respectively. 
 21. Condition of Premises. Tenant acknowledges that (a) it is in possession of and is fully familiar with the condition of the 771 Premises and, notwithstanding anything contained in the
Restated Lease to the contrary, agrees to take the same in its condition “as is” as of the Execution Date, and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the 771 Premises for Tenant’s continued
occupancy or to pay for any improvements to the 771 Premises, except as may be expressly provided in the section above entitled “771 Lower Level Landlord Work” or in the Restated Lease. Tenant acknowledges that (y) it is fully
familiar with the condition of the Substitute 777 Premises and, notwithstanding anything contained in the Restated Lease to the contrary, agrees to take the same in its condition “as is” as of the Substitute 777 Premises Commencement Date,
and (z) Landlord shall have no obligation to alter, repair or otherwise prepare the Substitute 777 Premises for Tenant’s occupancy or to pay for any improvements to the Substitute 777 Premises, except (i) as may be expressly provided
in the Restated Lease, (ii) that Landlord shall promptly remove all furniture currently in the Substitute 777 Premises and repair any and all damage to the Substitute 777 Premises caused thereby and (iii) that Landlord shall promptly correct
and repair minor punchlist items, such as broken door locks and paint touch-up, to be itemized in a notice prepared by Tenant within thirty (30) days of the date hereof. 
 22. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Landlord
harmless from any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by it or claiming to have been employed or engaged by it. Landlord represents and warrants that it has not dealt with any broker or
agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Tenant harmless from any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by it or claiming to
have been employed or engaged by it. 
 23. No Default. Tenant represents, warrants and covenants that, to the best of
Tenant’s knowledge, Landlord and Tenant are not in default of any of their respective obligations under the Restated Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by
either Landlord or Tenant thereunder. 

  
 9 

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 24. Effect of Amendment. Except as modified by this Amendment, the Restated Lease and
all the covenants, agreements, terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Amendment shall bind
and inure to the benefit of the parties hereto and their respective successors and, except as otherwise provided in the Restated Lease, their respective assigns. In the event of any conflict between the terms contained in this Amendment and the
Restated Lease, the terms herein contained shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Restated Lease shall mean the Restated Lease, as
modified by this Amendment. 
 25. Miscellaneous. This Amendment becomes effective only upon execution and delivery
hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits
hereto are incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or otherwise until
execution by and delivery to both Landlord and Tenant. 
 26. Counterparts. This Amendment may be executed in one or more
counterparts, each of which, when taken together, shall constitute one and the same document. 
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and
year first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Amendment. 
  

			
	LANDLORD:
	
	 BMR-LANDMARK AT EASTVIEW LLC,

a Delaware limited liability company

		
	 By:
	 	 /s/ Kevin Simonsen

	 Name:
	 	 Kevin Simonsen

	 Title:
	 	 VP, Real Estate Counsel

	
	TENANT:
	
	 PROGENICS PHARMACEUTICALS, INC.,

a Delaware corporation

		
	 By:
	 	 /s/ Robert A. McKinney

	 Name:
	 	 ROBERT A. MCKINNEY

	 Title:
	 	 CFO & SVP2005 Stock Incentive Plan, as Amended

 Exhibit 10.2 
 PROGENICS PHARMACEUTICALS, INC. 
 2005 STOCK INCENTIVE PLAN

 (As amended and effective as of June 13, 2012) 

 

	1.	PURPOSE 

 The purpose of
the Progenics Pharmaceuticals, Inc. 2005 Stock Incentive Plan is to further align the interests of employees, officers, non-employee directors and other individual service providers with those of the stockholders by providing incentive compensation
opportunities tied to the performance of the Common Stock and by promoting increased ownership of the Common Stock by such individuals. The Plan is also intended to advance the interests of the Company and its stockholders by attracting,
retaining and motivating key personnel upon whose judgment, initiative and effort the successful conduct of the Company’s business is largely dependent. 
  

	2.	DEFINITIONS 

 Wherever the
following capitalized terms are used in the Plan, they shall have the meanings specified below: 
  

	(a)	Award means an award of a Stock Option, Stock Appreciation Right, Restricted Stock Award, Stock Unit Award, Stock Award or Performance Award granted under the
Plan. 

  

	(b)	Award Agreement means a written or electronic agreement entered into between the Company and a Participant setting forth the terms and conditions of an Award.

  

	(c)	Board means the Board of Directors of the Company. 

  

	(d)	Change in Control shall have the meaning set forth in Section 13.2 hereof. 

 

	(e)	Code means the Internal Revenue Code of 1986, as amended. 

  

	(f)	Committee means the Compensation Committee of the Board or a successor thereof, or any other committee of the Board appointed by the Board to administer the Plan
from time to time. 

  

	(g)	Common Stock means the Company’s Common Stock, par value $.0013 per share. 

 

	(h)	Company means Progenics Pharmaceuticals, Inc., a Delaware corporation. 

 

	(i)	Date of Grant means the date on which an Award under the Plan is granted by the Committee, or such later date as the Committee may specify to be the effective
date of an Award. 

  

	(j)	Disability means a Participant being considered “disabled” within the meaning of Section 409A(a)(2)(C) of the Code, unless otherwise provided in
an Award Agreement. 

  

	(k)	Eligible Person means any person who is an employee, officer, director, consultant, advisor or other individual service provider of the Company or any
Subsidiary, as determined by the Committee, or any person who is determined by the Committee to be a prospective employee, officer, director, consultant, advisor or other individual service provider of the Company or any Subsidiary.

  

	(l)	Exchange Act means the Securities Exchange Act of 1934, as amended. 

 

	(m)	Fair Market Value with respect to the value of a share of Common Stock as of a particular day, shall mean the last reported sale price (as reported on the
NASDAQ) of the Common Stock on such day (unless such day is not a trading day, in which case, on the last trading day immediately preceding such day on which the Common Stock is traded on the NASDAQ). If the Common Stock is not listed on the
NASDAQ, the Committee shall determine in good faith the Fair Market Value in whatever manner it considers appropriate, taking into account to the extent necessary the requirements of Section 409A of the Code. 

 

	(n)	Incentive Stock Option means a Stock Option granted under Section 6 hereof that is intended to meet the requirements of section 422 of the Code and the
regulations promulgated thereunder. 

  

	(o)	NASDAQ means The Nasdaq Stock Market’s National Market. 

  

	(p)	Nonqualified Stock Option means a Stock Option granted under Section 6 hereof that is not an Incentive Stock Option. 

 

	(q)	Participant means any Eligible Person who holds an outstanding Award under the Plan. 

	(r)	Performance Awards means an Award under Section 11 hereof entitling a Participant to a payment in cash at the end of a performance period, if the
performance and other conditions established by the Committee are satisfied. 

  

	(s)	Plan means this Progenics Pharmaceuticals, Inc. 2005 Stock Incentive Plan as amended herein, and as may be amended from time to time, effective as provided in
Section 15.1 hereof. 

  

	(t)	Restricted Stock Award means a grant of shares of Common Stock to an Eligible Person under Section 8 hereof that are issued subject to such vesting and
transfer restrictions and such other conditions as are set forth in the Plan and the applicable Award Agreement. 

  

	(u)	Section 162(m) Award means any Award that is intended to qualify for the “performance-based” compensation exception under section 162(m) of the
Code and the regulations promulgated thereunder. 

  

	(v)	Service means a Participant’s employment or other service relationship with the Company or any Subsidiary. 

 

	(w)	Stock Appreciation Right means a contractual right granted to an Eligible Person under Section 7 hereof entitling such Eligible Person to receive a payment,
representing the difference between the base price per share of the right and the Fair Market Value of a share of Common Stock at such time, and subject to such conditions, as are set forth in the Plan and the applicable Award Agreement.

  

	(x)	Stock Award means a grant of shares of Common Stock to an Eligible Person under Section 10 hereof entitling a Participant to shares of Common Stock that are
issued free of transfer restrictions and forfeiture conditions. 

  

	(y)	Stock Option means a contractual right granted to an Eligible Person under Section 6 hereof to purchase shares of Common Stock at such time and price, and
subject to such conditions, as are set forth in the Plan and the applicable Award Agreement. 

  

	(z)	Stock Unit Award means a contractual right granted to an Eligible Person under Section 9 hereof representing notional unit interests equal in value to a
share of Common Stock to be paid and distributed at such times, and subject to such conditions, as are set forth in the Plan and the applicable Award Agreement. 

 

	(aa)	Subsidiary means an entity (whether or not a corporation) that is wholly or majority owned or controlled, directly or indirectly, by the Company, or any other
affiliate of the Company that is so designated, from time to time, by the Committee; provided, however, that with respect to Incentive Stock Options, the term “Subsidiary” shall include only an entity that qualifies under section 424(f) of
the Code as a “subsidiary corporation” with respect to the Company. 

  

	3.	ADMINISTRATION 

Section 3.1 Committee Members. The Plan shall be administered by a Committee comprised of no fewer than two members of
the Board. It is intended that each Committee member shall satisfy the requirements for (i) an “independent director” under rules adopted by the NASDAQ, (ii) a “nonemployee director” for purposes of such Rule 16b-3
under the Exchange Act and (iii) an “outside director” under section 162(m) of the Code. No member of the Committee shall be liable for any action or determination made in good faith by the Committee with respect to the Plan or
any Award hereunder. 
 Section 3.2 Committee Authority. The Committee shall have such powers and authority
as may be necessary or appropriate for the Committee to carry out its functions as described in the Plan. Subject to the express limitations of the Plan, the Committee shall have authority in its discretion to determine the Eligible Persons to
whom, and the time or times at which, Awards may be granted, the number of shares, units or other rights subject to each Award, the exercise, base or purchase price of an Award (if any), the time or times at which an Award will become vested,
exercisable or payable, the performance criteria, performance goals and other conditions of an Award, the duration of the Award, and all other terms of the Award. Subject to the terms of the Plan, the Committee shall have the authority to amend
the terms of an Award in any manner that is not inconsistent with the Plan, provided that no such action shall adversely affect the rights of a Participant with respect to an outstanding Award without the Participant’s consent. The
Committee shall also have discretionary authority to interpret the Plan, to make all factual determinations under the Plan, and to make all other determinations necessary or advisable for Plan administration, including, without limitation, to
correct any defect, to supply any omission or to reconcile any inconsistency in the Plan or any Award Agreement hereunder. The Committee may prescribe, amend, and rescind rules and regulations relating to the Plan. The Committee’s
determinations under the Plan need not be uniform and may be made by the Committee selectively among Participants and Eligible Persons, whether or not such persons are similarly situated. The Committee shall, in its discretion, consider such
factors as it deems relevant in making its interpretations, determinations and actions under the Plan including, without limitation, the recommendations or advice of any officer or employee of the Company or such attorneys, consultants, accountants
or other advisors as it may select. All interpretations, determinations, and actions by the Committee shall be final, conclusive, and binding upon all parties. 

 Section 3.3 Delegation of Authority. The Committee shall have the right,
from time to time, to delegate to one or more officers of the Company the authority of the Committee to grant Awards under the Plan, subject to the requirements of section 157(c) of the Delaware General Corporation Law (or any successor provision)
and such other limitations as the Committee shall determine. In no event shall any such delegation of authority be permitted with respect to Awards to any members of the Board or to any Eligible Person who is subject to Rule 16b-3 under the
Exchange Act or who is a covered employee under section 162(m) of the Code. The Committee shall also be permitted to delegate, to any appropriate officer or employee of the Company, responsibility for performing ministerial functions under the
Plan. In the event that the Committee’s authority is delegated to officers or employees in accordance with the foregoing, all provisions of the Plan relating to the Committee shall be interpreted in a manner consistent with the foregoing
by treating any such reference as a reference to such officer or employee for such purpose. Any action undertaken in accordance with the Committee’s delegation of authority hereunder shall have the same force and effect as if such action
was undertaken directly by the Committee and shall be deemed for all purposes of the Plan to have been taken by the Committee. 

Section 3.4 Grants to Non-Employee Directors. Any Awards or formula for granting Awards under the Plan made to
non-employee directors shall be approved by the Board. With respect to awards granted to such directors, all rights, powers and authorities vested in the Committee under the Plan shall instead be exercised by the Board, and all provisions of
the Plan relating to the Committee shall be interpreted in a manner consistent with the foregoing by treating any such reference as a reference to the Board for such purpose. 

 

	4.	SHARES SUBJECT TO THE PLAN 

Section 4.1 Share Limitation. Subject to adjustment pursuant to Section 4.2 hereof, the maximum aggregate number
of shares of Common Stock which may be issued under all Awards granted to Participants under the Plan shall be 8,450,000 shares. Shares of Common Stock issued under the Plan may be either authorized but unissued shares or shares held in the
Company’s treasury. Shares of Common Stock subject to Awards of Stock Options or Stock Appreciation Rights that are settled in Common Stock shall be counted against the maximum share limitations of this Section 4.1 as one share of
Common Stock for every share of Common Stock subject thereto, regardless of the number of shares of Common Stock actually issued to settle the Stock Option or Stock Appreciation Right upon exercise. Shares of Common Stock subject to Awards of
Restricted Stock Awards, Stock Unit Awards, Stock Awards, or share-based Performance Awards, if any, shall be counted against the maximum share limitations of this Section 4.1 as 1.2 shares of Common Stock for every share of Common Stock
subject thereto. To the extent that any Award under the Plan payable in shares of Common Stock is forfeited, cancelled, returned to the Company for failure to satisfy vesting requirements or upon the occurrence of other forfeiture events, or
otherwise terminates, in whole or in part, without payment being made thereunder, the shares of Common Stock remaining subject thereto at the time of such forfeiture, cancellation, return or other termination will no longer be counted against the
foregoing maximum share limitations and may again be made subject to Awards under the Plan pursuant to such limitations. Awards under the Plan that are settled in cash and not in shares of Common Stock shall not be counted against the foregoing
maximum share limitations. Shares that are withheld from an Award by the Participant in payment of the exercise or purchase price or separately surrendered by the Participant, or taxes relating to such an Award shall be deemed to constitute
delivered shares and will not be available for future Awards under the Plan. 
 Section 4.2 Adjustments. If
there shall occur any change with respect to the outstanding shares of Common Stock by reason of any recapitalization, reclassification, stock dividend, extraordinary dividend, stock split, reverse stock split, or other distribution with respect to
the shares of Common Stock, or any merger, reorganization, consolidation, combination, spin-off or other similar corporate change, or any other change affecting the Common Stock, the Committee shall, in the manner and to the extent that it deems
appropriate and equitable to the Participants and consistent with the terms of the Plan, cause an adjustment to be made in (i) the maximum numbers and kind of shares provided in Section 4.1 hereof, (ii) the maximum numbers and kind of
shares or units set forth in Sections 6.1, 7.1, 8.1, 9.1 and 10.1 hereof, (iii) the numbers and kind of shares of Common Stock, units, or other rights subject to then outstanding Awards, (iv) the price for each share or unit or other right
subject to then outstanding Awards, (v) the performance measures or goals relating to an Award and (vi) any other terms of an Award that are affected by the event to prevent dilution or enlargement of a Participant’s rights under an
Award. Notwithstanding the foregoing, in the case of Incentive Stock Options, any such adjustments shall, to the extent practicable, be made in a manner consistent with the requirements of section 424(a) of the Code. 

	5.	PARTICIPATION AND AWARDS 

Section 5.1 Designation of Participants. All Eligible Persons are eligible to be designated by the Committee to receive
Awards and become Participants under the Plan. The Committee has the authority, in its discretion, to determine and designate from time to time those Eligible Persons who are to be granted Awards, the types of Awards to be granted and the
number of shares of Common Stock or units subject to Awards granted under the Plan. In selecting Eligible Persons to be Participants and in determining the type and amount of Awards to be granted under the Plan, the Committee shall consider any
and all factors that it deems relevant or appropriate. 
 Section 5.2 Determination of Awards. The Committee
shall determine the terms and conditions of all Awards granted to Participants in accordance with its authority under Section 3.2 hereof. An Award may consist of one type of right or benefit hereunder or of two or more such rights or
benefits granted in tandem or in the alternative. In the case of any fractional share or unit resulting from the grant, vesting, payment or crediting of dividends or dividend equivalents under an Award, the Committee shall have the
discretionary authority to (i) disregard such fractional share or unit, (ii) round such fractional share or unit to the nearest lower or higher whole share or unit, or (iii) convert such fractional share or unit into a right to
receive a cash payment. To the extent deemed necessary by the Committee, an Award shall be evidenced by an Award Agreement as described in Section 14.1 hereof. 

 

	6.	STOCK OPTIONS 

Section 6.1 Grant of Stock Option. A Stock Option may be granted to any Eligible Person selected by the
Committee. Subject to the provisions of Section 6.7 hereof and section 422 of the Code, each Stock Option shall be designated, in the discretion of the Committee, as an Incentive Stock Option or as a Nonqualified Stock Option. The maximum
number of shares of Common Stock that may be subject to Stock Options granted to any Participant during any calendar year shall be limited to 750,000 shares (subject to adjustment as provided in Section 4.2 hereof). 

Section 6.2 Exercise Price. The exercise price per share of a Stock Option shall not be less than 100 percent of the
Fair Market Value of the shares of Common Stock on the Date of Grant, provided that the Committee may in its discretion specify for any Stock Option an exercise price per share that is higher than the Fair Market Value on the Date of Grant.

 Section 6.3 Vesting of Stock Options. The Committee shall in its discretion prescribe the time or times at
which, or the conditions upon which, a Stock Option or portion thereof shall become vested and/or exercisable. The requirements for vesting and exercisability of a Stock Option may be based on the continued Service of the Participant with the
Company or a Subsidiary for a specified time period (or periods) or on the attainment of a specified performance goal (or goals) established by the Committee in its discretion. The Committee may, in its discretion, accelerate the vesting or
exercisability of any Stock Option at any time. 
 Section 6.4 Term of Stock Options. The Committee shall in
its discretion prescribe in an Award Agreement the period during which a vested Stock Option may be exercised, provided that the maximum term of a Stock Option shall be ten years from the Date of Grant. A Stock Option may be earlier terminated
as specified by the Committee and set forth in an Award Agreement upon or following the termination of a Participant’s Service with the Company or any Subsidiary, including by reason of voluntary resignation, death, Disability, termination for
cause or any other reason. Except as otherwise provided in this Section 6 or in an Award Agreement, no Stock Option may be exercised at any time during the term thereof unless the Participant is then in the Service of the Company or one of
its Subsidiaries. 

 Section 6.5 Stock Option Exercise; Tax Withholding. Subject to such terms
and conditions as shall be specified in an Award Agreement, a Stock Option may be exercised in whole or in part at any time during the term thereof by notice in the form required by the Company, together with payment of the aggregate exercise price
therefor and applicable withholding tax. Payment of the exercise price shall be made in the manner set forth in an Award Agreement, unless otherwise provided by the Committee: (i) in cash or by cash equivalent acceptable to the Committee;
(ii) by payment in shares of Common Stock that have been held by the Participant for at least six months (or such period as the Committee may deem appropriate for accounting purposes or otherwise), valued at the Fair Market Value of such shares
on the date of exercise; (iii) through an open-market broker-assisted sales transaction pursuant to which the Company is promptly delivered the amount of proceeds necessary to satisfy the exercise price; (iv) by a combination of the
foregoing methods; or (v) by such other method as may be approved by the Committee and set forth in an Award Agreement. In addition to and at the time of payment of the exercise price, the Participant shall pay to the Company the full
amount of any and all applicable income tax, employment tax and other amounts required to be withheld in connection with such exercise, payable under such of the methods described above for the payment of the exercise price as may be approved by the
Committee and set forth in an Award Agreement. 
 Section 6.6 Limited Transferability of Nonqualified Stock
Options. All Stock Options shall be nontransferable except (i) upon the Participant’s death, in accordance with Section 14.3 hereof or (ii) in the case of Nonqualified Stock Options only, for the transfer of all or part of
the Stock Option to a Participant’s “family member” (as defined for purposes of the Form S-8 registration statement under the Securities Act of 1933), or as otherwise permitted by the Committee, in each case as may be approved by the
Committee in its discretion at the time of proposed transfer. The transfer of a Nonqualified Stock Option may be subject to such terms and conditions as the Committee may in its discretion impose from time to time. Subsequent transfers of
a Nonqualified Stock Option shall be prohibited other than in accordance with Section 14.3 hereof. 

Section 6.7 Additional Rules for Incentive Stock Options. 

 

	(i)	Eligibility. An Incentive Stock Option may only be granted to an Eligible Person who is considered an employee under Treasury Regulation §1.421-7(h) of the
Company or any Subsidiary. 

  

	(ii)	Annual Limits. No Incentive Stock Option shall be granted to an Eligible Person as a result of which the aggregate Fair Market Value (determined as of the Date of
Grant) of the stock with respect to which Incentive Stock Options are exercisable for the first time in any calendar year under the Plan and any other stock option plans of the Company or any Subsidiary would exceed $100,000, determined in
accordance with section 422(d) of the Code. This limitation shall be applied by taking Incentive Stock Options into account in the order in which granted. 

 

	(iii)	Ten Percent Stockholders. If a Stock Option granted under the Plan is intended to be an Incentive Stock Option, and if the Participant, at the time of grant, owns
stock possessing ten percent or more of the total combined voting power of all classes of Common Stock of the Company or any Subsidiary, then (A) the Stock Option exercise price per share shall in no event be less than 110 percent of the Fair
Market Value of the Common Stock on the date of such grant and (B) such Stock Option shall not be exercisable after the expiration of five years following the date such Stock Option is granted. 

 

	(iv)	Termination of Employment. An Award of an Incentive Stock Option may provide that such Stock Option may be exercised not later than 3 months following termination
of employment of the Participant with the Company and all Subsidiaries, or not later than one year following death or a permanent and total disability within the meaning of section 22(e)(3) of the Code, as and to the extent determined by the
Committee to comply with the requirements of section 422 of the Code. 

  

	(v)	Other Terms and Conditions; Nontransferability. Any Incentive Stock Option granted hereunder shall contain such additional terms and conditions, not inconsistent
with the terms of the Plan, as are deemed necessary or desirable by the Committee, which terms, together with the terms of the Plan, shall be intended and interpreted to cause such Incentive Stock Option to qualify as an “incentive stock
option” under section 422 of the Code. An Award Agreement for an Incentive Stock Option may provide that such Stock Option shall be treated as a Nonqualified Stock Option to the extent that certain requirements applicable to
“incentive stock options” under the Code shall not be satisfied. An Incentive Stock Option shall by its terms be nontransferable other than by will or by the laws of descent and distribution, and shall be exercisable during the
lifetime of a Participant only by such Participant. 

  

	(vi)	Disqualifying Dispositions. If shares of Common Stock acquired by exercise of an Incentive Stock Option are disposed of within two years following the Date of
Grant or one year following the transfer of such shares to the Participant upon exercise, the Participant shall, promptly following such disposition, notify the Company in writing of the date and terms of such disposition and provide such other
information regarding the disposition as the Company may reasonably require. 

 Section 6.8 Repricing of Stock Options Prohibited. Subject to the
anti-dilution adjustment provisions contained in Section 4.2 hereof, without the prior approval of the Company’s stockholders, evidenced by a majority of votes cast, neither the Committee nor the Board shall cause the cancellation,
substitution or amendment of a Stock Option that would have the effect of reducing the exercise price of such a Stock Option previously granted under the Plan, or otherwise approve any modification to such a Stock Option that would be treated as a
“repricing.” 
  

	7.	STOCK APPRECIATION RIGHTS 

Section 7.1 Grant of Stock Appreciation Rights. A Stock Appreciation Right may be granted to any Eligible Person
selected by the Committee. Stock Appreciation Rights may be granted on a basis that allows for the exercise of the right by the Participant or that provides for the automatic payment of the right upon a specified date or event. The maximum
number of shares of Common Stock that may be subject to Stock Appreciation Rights granted to any Participant during any calendar year shall be limited to 750,000 shares (subject to adjustment as provided in Section 4.2 hereof). 

Section 7.2 Freestanding Stock Appreciation Rights. A Stock Appreciation Right may be granted without any related
Stock Option. The Committee shall in its discretion prescribe the time or times at which, or the conditions upon which, a Stock Appreciation Right or portion thereof shall become vested and/or exercisable. The requirements for vesting and
exercisability of a Stock Appreciation Right may be based on the continued Service of a Participant with the Company or a Subsidiary for a specified time period (or periods) or on the attainment of a specified performance goal (or goals) established
by the Committee in its discretion. A Stock Appreciation Right will be exercisable or payable at such time or times as determined by the Committee, provided that the maximum term of a Stock Appreciation Right shall be ten years from the Date of
Grant. The Committee may, in its discretion, accelerate the vesting or exercisability of any Stock Appreciation Right at any time. The base price of a Stock Appreciation Right granted without any related Stock Option shall be determined by
the Committee in its sole discretion; provided, however, that the base price per share of any such freestanding Stock Appreciation Right shall not be less than 100 percent of the Fair Market Value of the shares of Common Stock on the Date of Grant.

 Section 7.3 Tandem Stock Option/Stock Appreciation Rights. A Stock Appreciation Right may be granted in
tandem with a Stock Option, either at the time of grant or at any time thereafter during the term of the Stock Option. A tandem Stock Option/Stock Appreciation Right will entitle the holder to elect, as to all or any portion of the number of
shares subject to the Award, to exercise either the Stock Option or the Stock Appreciation Right, resulting in the reduction of the corresponding number of shares subject to the right so exercised as well as the tandem right not so exercised. A
Stock Appreciation Right granted in tandem with a Stock Option hereunder shall have a base price per share equal to the per share exercise price of the Stock Option, will be vested and exercisable at the same time or times that a related Stock
Option is vested and exercisable, and will expire no later than the time at which the related Stock Option expires. 

 Section 7.4 Payment of Stock Appreciation Rights. A Stock Appreciation
Right will entitle the holder, upon exercise or other payment of the Stock Appreciation Right, as applicable, to receive an amount determined by multiplying: (i) the excess of the Fair Market Value of a share of Common Stock on the date of
exercise or payment of the Stock Appreciation Right over the base price of such Stock Appreciation Right, by (ii) the number of shares as to which such Stock Appreciation Right is exercised or paid. Payment of the amount determined under
the foregoing may be made, as approved by the Committee and set forth in the Award Agreement, in shares of Common Stock valued at their Fair Market Value on the date of exercise or payment, in cash, or in a combination of shares of Common Stock and
cash, subject to applicable tax withholding requirements. 
 Section 7.5 Repricing of Stock Appreciation Rights
Prohibited. Subject to the anti-dilution adjustment provisions contained in Section 4.2 hereof, without the prior approval of the Company’s stockholders, evidenced by a majority of votes cast, neither the Committee nor the Board shall
cause the cancellation, substitution or amendment of a Stock Appreciation Right that would have the effect of reducing the base price of such a Stock Appreciation Right previously granted under the Plan, or otherwise approve any modification to such
a Stock Appreciation Right that would be treated as a “repricing.” 
  

	8.	RESTRICTED STOCK AWARDS 

Section 8.1 Grant of Restricted Stock Awards. A Restricted Stock Award may be granted to any Eligible Person selected
by the Committee. The Committee may require the payment by the Participant of a specified purchase price in connection with any Restricted Stock Award. The Committee may grant Restricted Stock Awards that are Section 162(m) Awards, as
well as Restricted Stock Awards that are not Section 162(m) Awards. The maximum number of shares of Common Stock that may be subject to Restricted Stock Awards granted to a Participant during any one calendar year shall be limited to
250,000 shares (subject to adjustment as provided in Section 4.2 hereof). 
 Section 8.2 Vesting
Requirements. The restrictions imposed on shares of Common Stock granted under a Restricted Stock Award shall lapse in accordance with the vesting requirements specified by the Committee in the Award Agreement. The requirements for vesting
of a Restricted Stock Award may be based on the continued Service of the Participant with the Company or its Subsidiaries for a specified time period (or periods) or on the attainment of a specified performance goal (or goals) established by the
Committee in its discretion. The Committee may, in its discretion, accelerate the vesting of a Restricted Stock Award at any time. In the case of any Restricted Stock Award that is a Section 162(m) Award, any such performance-based
vesting requirements shall be based upon the performance criteria identified in Section 12.2 hereof, and the terms of the Award shall otherwise comply with the requirements described in Section 12.3 hereof. If the vesting requirements
of a Restricted Stock Award shall not be satisfied, the Award shall be forfeited and the shares of Common Stock subject to the Award shall be returned to the Company. In the event that the Participant paid any purchase price with respect to
such forfeited shares, unless otherwise provided by the Committee in an Award Agreement, the Company will refund to the Participant the lesser of (i) such purchase price and (ii) the Fair Market Value of such shares on the date of
forfeiture. 
 Section 8.3 Restrictions. Shares granted under any Restricted Stock Award may not be
transferred, assigned or subject to any encumbrance, pledge, or charge until all applicable restrictions are removed or have expired, unless otherwise allowed by the Committee. Failure to satisfy any applicable restrictions shall result in the
shares subject to the Restricted Stock Award being forfeited and returned to the Company. In the event that the Participant paid any purchase price with respect to such forfeited shares, unless otherwise provided by the Committee in an Award
Agreement, the Company will refund to the Participant the lesser of (i) such purchase price and (ii) the Fair Market Value of such shares on the date of forfeiture. The Committee may require in an Award Agreement that certificates
representing the shares granted under a Restricted Stock Award bear a legend making appropriate reference to the restrictions imposed, and that certificates representing the shares granted or sold under a Restricted Stock Award will remain in the
physical custody of an escrow holder until all restrictions are removed or have expired. 

 Section 8.4 Rights as Stockholder. Subject to the foregoing provisions of
this Section 8 and the applicable Award Agreement, the Participant shall have all rights of a stockholder with respect to the shares granted to the Participant under a Restricted Stock Award, including the right to vote the shares and receive
all dividends and other distributions paid or made with respect thereto, unless the Committee determines otherwise at the time the Restricted Stock Award is granted. The Committee may provide in an Award Agreement for the payment of dividends
and distributions to the Participant at such times as paid to stockholders generally or at the times of vesting or other payment of the Restricted Stock Award. 
 Section 8.5 Section 83(b) Election. If a Participant makes an election pursuant to section 83(b) of the Code with respect to a Restricted Stock Award, the Participant shall file,
within 30 days following the Date of Grant, a copy of such election with the Company and with the Internal Revenue Service, in accordance with the regulations under section 83 of the Code. The Committee may provide in an Award Agreement that
the Restricted Stock Award is conditioned upon the Participant’s making or refraining from making an election with respect to the Award under section 83(b) of the Code. 

 

	9.	STOCK UNIT AWARDS 

Section 9.1 Grant of Stock Unit Awards. A Stock Unit Award may be granted to any Eligible Person selected by the
Committee. The value of each stock unit under a Stock Unit Award is equal to the Fair Market Value of the Common Stock on the applicable date or time period of determination, as specified by the Committee. The Committee may grant Stock Unit
Awards that are Section 162(m) Awards, as well as Stock Unit Awards that are not Section 162(m) Awards. The maximum number of units that may be subject to Stock Unit Awards granted to a Participant during any one calendar year shall
be limited to 250,000 units (subject to adjustment as provided in Section 4.2 hereof). A Stock Unit Award shall be subject to such restrictions and conditions as the Committee shall determine. A Stock Unit Award may be granted
together with a dividend equivalent right with respect to the shares of Common Stock subject to the Award, which may be accumulated and may be deemed reinvested in additional stock units, as determined by the Committee in its discretion. 

Section 9.2 Vesting of Stock Unit Awards. On the Date of Grant, the Committee shall, in its discretion, determine any
vesting requirements with respect to a Stock Unit Award, which shall be set forth in the Award Agreement. The requirements for vesting of a Stock Unit Award may be based on the continued Service of the Participant with the Company or its
Subsidiaries for a specified time period (or periods) or on the attainment of a specified performance goal (or goals) established by the Committee in its discretion. The Committee may, in its discretion, accelerate the vesting of a Stock Unit
Award at any time. In the case of any Stock Unit Award that is a Section 162(m) Award, any such performance-based vesting requirements shall be based upon the performance criteria identified in Section 12.2 hereof, and the terms of
the Award shall otherwise comply with the requirements described in Section 12.3 hereof. A Stock Unit Award may also be granted on a fully vested basis, with a deferred payment date as may be determined by the Committee or elected by the
Participant in accordance with the rules established by the Committee. 
 Section 9.3 Payment of Stock Unit
Awards. A Stock Unit Award shall become payable to a Participant at the time or times determined by the Committee and set forth in the Award Agreement, which may be upon or following the vesting of the Award. Payment of a Stock Unit Award
may be made, at the discretion of the Committee, in cash or in shares of Common Stock, or in a combination thereof, subject to applicable tax withholding requirements. Any cash payment of a Stock Unit Award shall be made based upon the Fair
Market Value of the Common Stock, determined on such date or over such time period as determined by the Committee. In the case of a Participant who is a “specified employee” as defined in Section 409A of the Code at the time of
any payment of a Stock Unit Award upon the Participant’s termination of Service, the payments under the Stock Unit Award shall be deferred until the date that is six months following the Participant’s termination of Service to the extent
necessary to comply with Section 409A of the Code, with the terms of such deferral and payment to be made in the manner determined by the Committee and set forth in the Award Agreement. 

 Section 9.4 No Rights as Stockholder. The Participant shall not have any
rights as a stockholder with respect to the shares subject to a Stock Unit Award until such time as shares of Common Stock are delivered to the Participant pursuant to the terms of the Award Agreement. 

 

	10.	STOCK AWARDS 

Section 10.1 Grant of Stock Awards. A Stock Award may be granted to any Eligible Person selected by the
Committee. A Stock Award may be granted for past services, in lieu of bonus or other cash compensation, as directors’ compensation or for any other valid purpose as determined by the Committee. A Stock Award granted to an Eligible
Person represents shares of Common Stock that are issued free of restrictions on transfer and free of forfeiture conditions and to which such Eligible Person is entitled all incidents of ownership, except as otherwise provided in the Plan and the
Award Agreement. The Committee may, in connection with any Stock Award, require the payment of a specified purchase price. The Committee may grant Stock Awards that are Section 162(m) Awards, as well as Stock Awards that are not
Section 162(m) Awards. The maximum number of shares of Common Stock that may be subject to Stock Awards granted to a Participant during any one calendar year shall be limited to 250,000 shares (subject to adjustment as provided in
Section 4.2 hereof). 
 Section 10.2 Rights as Stockholder. Subject to the foregoing provisions of this
Section 10 and the applicable Award Agreement, upon the issuance of the shares of Common Stock under a Stock Award, the Participant shall have all rights of a stockholder with respect to the shares of Common Stock, including the right to vote
the shares and receive all dividends and other distributions paid or made with respect thereto. 
  

	11.	PERFORMANCE AWARDS 

Section 11.1 Grant of Performance Awards. The Committee may grant Performance Awards under the Plan, which shall
represent the right to receive a payment in cash if performance goals established by the Committee for a performance period are satisfied. The Committee may grant Performance Awards that are Section 162(m) Awards, as well as Performance
Awards that are not Section 162(m) Awards. At the time a Performance Award is granted, the Committee shall determine, in its sole discretion, the applicable performance period and performance goals to be achieved during the performance
period, as well as such other conditions as the Committee deems appropriate. The Committee may also determine a target payment amount or a range of payment amounts for each Award. The performance goals applicable to a Performance Award
grant may be subject to adjustments as the Committee shall deem appropriate to reflect significant unforeseen events, such as changes in law, accounting practices or unusual or nonrecurring items or occurrences. The Committee’s authority
to make such adjustments shall be subject to such limitations as the Committee deems appropriate in the case of a Performance Award that is a Section 162(m) Award. In the case of any Performance Award that is a Section 162(m) Award,
performance goals shall be based upon the performance criteria identified in Section 12.2 hereof, and the terms of the Award shall otherwise comply with the requirements described in Section 12.3 hereof. The maximum amount of cash
compensation that may be paid to a Participant during any one calendar year under Performance Awards shall be $1 million. 

Section 11.2 Payment of Performance Awards. At the end of the performance period, the Committee shall determine the
extent to which performance goals have been attained, or a degree of achievement between minimum and maximum levels, in order to establish the level of payment to be made, if any. Payments of Performance Awards shall generally be made as soon
as practicable following the end of the performance period, subject to any tax withholding requirements. In the case of a Participant who is a “specified employee” as defined in Section 409A of the Code at the time of any payment
of a Performance Award upon the Participant’s termination of Service, the payments under the Performance Award shall be deferred until the date that is six months following the Participant’s termination of Service to the extent necessary
to comply with Section 409A of the Code, with the terms of such deferral and payment to be made in the manner determined by the Committee and set forth in the Award Agreement. 

	12.	SECTION 162(M) AWARDS 

Section 12.1 Awards. Awards of Stock Options and Stock Appreciation Rights granted under the Plan are intended by their
terms to qualify as Section 162(m) Awards. Restricted Stock Awards, Stock Unit Awards, Stock Awards and Performance Awards granted under the Plan may qualify as Section 162(m) Awards if the Awards are granted or become payable or
vested based upon pre-established performance goals in accordance with this Section 12. 
 Section 12.2
Performance Criteria. In the case of a Restricted Stock Award, Stock Unit Award, Stock Award or Performance Award that is intended to be a Section 162(m) Award, the performance criteria upon which the grant, payment or vesting may be
based shall be limited to one or more of the following performance measures, which may be applied with respect to the Company, any Subsidiary or any business unit: (i) total stockholder return; (ii) stock price increase; (iii) return
on equity; (iv) return on capital; (v) return on investment; (vi) earnings per share, diluted or basic; (vii) EBIT (earnings before interest and taxes); (viii) EBITDA (earnings before interest, taxes, depreciation and
amortization); (ix) cash flow (including operating cash flow, free cash flow, discounted cash flow, and cash flow in excess of costs of capital); (x) net or gross revenue; (xi) operating expenses; (xii) gross or operating margin;
(xiii) execution of a corporate collaboration agreement relating to a product candidate of the Company; (xiv) acceptance by the U.S. Food and Drug Administration (“FDA”) or a comparable foreign regulatory authority of a final New
Drug Application, a Biologic License Application or similar document; (xv) approval for marketing of a product candidate of the Company by the FDA or a comparable foreign regulatory authority; (xvi) obtaining a specified level of financing
for the Company, as determined by the Committee, including through government grants (or similar awards) and the issuance of securities; and (xvii) commencement of a particular stage of clinical trials for a product candidate of the
Company. The foregoing performance criteria shall have any reasonable definitions that the Committee may specify, which may include or exclude any items specified by the Committee, including but not limited to any or all of the following items:
discontinued operations, extraordinary, unusual or non-recurring items, effects of accounting changes, effects of currency or interest rate fluctuations, effects of financing activities (e.g., effect on earnings per share of issuing convertible debt
securities), changes in tax rates, expenses for restructuring or productivity initiatives, litigation losses, non-operating items, effects of acquisitions or divestitures and changes of law or regulation affecting the Company’s
business. The foregoing performance measures may be determined on an absolute basis or relative to internal goals or relative to levels attained in prior years, or related to other companies or indices, or as ratios expressing relationships
between two or more performance measures. In the case of Awards that are not Section 162(m) Awards, the Committee may designate performance criteria from among the foregoing or such other performance criteria as it shall determine in its
sole discretion. 
 Section 12.3 Section 162(m) Requirements. In the case of a Restricted Stock Award,
Stock Unit Award, Stock Award or Performance Award that is intended to be a Section 162(m) Award, the Committee shall make such determinations with respect to an Award as required by section 162(m) of the Code within 90 days after the beginning
of the performance period (or such other time period as is required under section 162(m) of the Code). As and to the extent required by section 162(m) of the Code, the terms of an Award that is a Section 162(m) Award must state, in terms
of an objective formula or standard, the method of computing the amount of compensation payable under the Award, and must preclude discretion to increase the amount of compensation payable under the terms of the Award (but may allow the Committee
discretion to decrease the amount of compensation payable). 

	13.	CHANGE IN CONTROL 

Section 13.1 Effect of Change in Control. The Committee may, at the time of the grant of an Award and as set forth in
an Award Agreement, provide for the effect of a “Change in Control” on an Award. Such provisions may include any one or more of the following: (i) the acceleration or extension of time periods for purposes of exercising, vesting
in, or realizing gain from any Award, (ii) the elimination or modification of performance or other conditions related to the payment or other rights under an Award, (iii) provision for the cash settlement of an Award for an equivalent cash
value, as determined by the Committee, or (iv) such other modification or adjustment to an Award as the Committee deems appropriate to maintain and protect the rights and interests of Participants upon or following a Change in Control. To
the extent necessary for compliance with Section 409A of the Code, an Award Agreement shall provide that an Award subject to the requirements of Section 409A that would otherwise become payable upon a Change in Control shall only become
payable to the extent that the requirements for a “change in control” for purposes of Section 409A have been satisfied. 
 Section 13.2 Definition of Change in Control. For purposes of the Plan, unless otherwise defined in an Award Agreement, a “Change in Control” shall be deemed to have occurred
upon: 
  

	(i)	a change in the composition of the Board such that during any period of two consecutive years, individuals who at the beginning of such period constitute the Board, and
any new director (other than a director designated by a person who has entered into an agreement with the Company to effect a transaction described in clause (ii) or (iii) of this Section 13.2) whose election by the Board or
nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds of the directors then still in office who either were directors at the beginning of the period or whose election or nomination for election was
previously so approved, cease for any reason to constitute at least a majority of the members thereof; 

  

	(ii)	the consummation of a merger, consolidation, reorganization or similar corporate transaction, whether or not the Company is the surviving corporation in such
transaction, in which outstanding shares of Common Stock are converted into (A) shares of stock of another company, other than a conversion into shares of voting common stock of the successor corporation (or a holding company thereof)
representing more than 50% of the voting power of all capital stock thereof outstanding immediately after the merger or consolidation, or (B) other securities (of either the Company or another company) or cash or other property;

  

	(iii)	any “Person” (as such term is used in Sections 13(d)(3) and 14(d)(2) of the Exchange Act), except that such term shall not include (A) the Company,
(B) a trustee or other fiduciary holding securities under an employee benefit plan of the Company, (C) an underwriter temporarily holding securities pursuant to an offering of such securities, or (D) a corporation owned, directly or
indirectly, by the stockholders of the Company in substantially the same proportions as their ownership of stock of the Company, who is or becomes the “Beneficial Owner” (as defined in Rule 13d-3 under the Exchange Act), directly or
indirectly, of securities of the Company (not including in the securities Beneficially Owned by such Person any securities acquired directly from the Company) representing 30% or more of the voting power of all capital stock thereof outstanding,
excluding any Person who is an officer or director of the Company or who becomes such a Beneficial Owner in connection with a transaction described in clause (ii) of this Section 13.2; or 

 

	(iv)	the consummation of (A) the sale or other disposition of all or substantially all of the assets of the Company, or (B) a complete liquidation or dissolution
of the Company. 

	14.	GENERAL PROVISIONS 

Section 14.1 Award Agreement. To the extent deemed necessary by the Committee, an Award under the Plan shall be
evidenced by an Award Agreement in a written or electronic form approved by the Committee setting forth the number of shares of Common Stock or units subject to the Award, the exercise price, base price, or purchase price of the Award, the time or
times at which an Award will become vested, exercisable or payable and the term of the Award. The Award Agreement may also set forth the effect on an Award of termination of Service under certain circumstances. The Award Agreement shall be
subject to and incorporate, by reference or otherwise, all of the applicable terms and conditions of the Plan, and may also set forth other terms and conditions applicable to the Award as determined by the Committee consistent with the limitations
of the Plan. Award Agreements evidencing Incentive Stock Options shall contain such terms and conditions as may be necessary to meet the applicable provisions of section 422 of the Code. The grant of an Award under the Plan shall not
confer any rights upon the Participant holding such Award other than such terms, and subject to such conditions, as are specified in the Plan as being applicable to such type of Award (or to all Awards) or as are expressly set forth in the Award
Agreement. The Committee need not require the execution of an Award Agreement by a Participant, in which case, acceptance of the Award by the Participant shall constitute agreement by the Participant to the terms, conditions, restrictions and
limitations set forth in the Plan and the Award Agreement as well as the administrative guidelines of the Company in effect from time to time. 
 Section 14.2 Forfeiture Events/Representations. The Committee may specify in an Award Agreement at the time of the Award that the Participant’s rights, payments and benefits
with respect to an Award shall be subject to reduction, cancellation, forfeiture or recoupment upon the occurrence of certain specified events, in addition to any otherwise applicable vesting or performance conditions of an Award. Such events
shall include, but shall not be limited to, termination of Service for cause, violation of material Company policies, breach of noncompetition, confidentiality or other restrictive covenants that may apply to the Participant, or other conduct by the
Participant that is detrimental to the business or reputation of the Company. The Committee may also specify in an Award Agreement that the Participant’s rights, payments and benefits with respect to an Award shall be conditioned upon the
Participant making a representation regarding compliance with noncompetition, confidentiality or other restrictive covenants that may apply to the Participant and providing that the Participant’s rights, payments and benefits with respect to an
Award shall be subject to reduction, cancellation, forfeiture or recoupment on account of a breach of such representation. 

Section 14.3 No Assignment or Transfer; Beneficiaries. Except as provided in Section 6.6 hereof, Awards under the
Plan shall not be assignable or transferable by the Participant, except by will or by the laws of descent and distribution, and shall not be subject in any manner to assignment, alienation, pledge, encumbrance or charge. Notwithstanding the
foregoing, the Committee may provide in an Award Agreement that the Participant shall have the right to designate a beneficiary or beneficiaries who shall be entitled to any rights, payments or other benefits specified under an Award following the
Participant’s death. During the lifetime of a Participant, an Award shall be exercised only by such Participant or such Participant’s guardian or legal representative. In the event of a Participant’s death, an Award may, to
the extent permitted by the Award Agreement, be exercised by the Participant’s beneficiary as designated by the Participant in the manner prescribed by the Committee or, in the absence of an authorized beneficiary designation, by the legatee of
such Award under the Participant’s will or by the Participant’s estate in accordance with the Participant’s will or the laws of descent and distribution, in each case in the same manner and to the same extent that such Award was
exercisable by the Participant on the date of the Participant’s death. 
 Section 14.4 Deferrals of
Payment. The Committee may in its discretion permit a Participant to defer the receipt of payment of cash or delivery of shares of Common Stock that would otherwise be due to the Participant by virtue of the exercise of a right or the
satisfaction of vesting or other conditions with respect to an Award. If any such deferral is to be permitted by the Committee, the Committee shall establish rules and procedures relating to such deferral in a manner intended to comply with the
requirements of Section 409A of the Code, including, without limitation, the time when an election to defer may be made, the time period of the deferral and the events that would result in payment of the deferred amount, the interest or other
earnings attributable to the deferral and the method of funding, if any, attributable to the deferred amount. 

 Section 14.5 Rights as Stockholder. A Participant shall have no rights as
a holder of shares of Common Stock with respect to any unissued securities covered by an Award until the date the Participant becomes the holder of record of such securities. Except as provided in Section 4.2 hereof, no adjustment or other
provision shall be made for dividends or other stockholder rights, except to the extent that the Award Agreement provides for dividend payments or dividend equivalent rights. 
 Section 14.6 Employment or Service. Nothing in the Plan, in the grant of any Award or in any Award Agreement shall confer upon any Eligible Person or Participant any right to continue
in the Service of the Company or any of its Subsidiaries, or interfere in any way with the right of the Company or any of its Subsidiaries to terminate the employment or other service relationship of an Eligible Person or Participant for any reason
at any time. 
 Section 14.7 Securities Laws. No shares of Common Stock will be issued or transferred
pursuant to an Award unless and until all then applicable requirements imposed by Federal and state securities and other laws, rules and regulations and by any regulatory agencies having jurisdiction, and by any exchanges upon which the shares of
Common Stock may be listed, have been fully met. As a condition precedent to the issuance of shares pursuant to the grant or exercise of an Award, the Company may require the Participant to take any reasonable action to meet such
requirements. The Committee may impose such conditions on any shares of Common Stock issuable under the Plan as it may deem advisable, including, without limitation, restrictions under the Securities Act of 1933, as amended, under the
requirements of any exchange upon which such shares of the same class are then listed, and under any blue sky or other securities laws applicable to such shares. The Committee may also require the Participant to represent and warrant at the
time of issuance or transfer that the shares of Common Stock are being acquired only for investment purposes and without any current intention to sell or distribute such shares. 

Section 14.8 Tax Withholding. The Participant shall be responsible for payment of any taxes or similar charges
required by law to be withheld from an Award or an amount paid in satisfaction of an Award, which shall be paid by the Participant on or prior to the payment or other event that results in taxable income in respect of an Award. The Award
Agreement may specify the manner in which the withholding obligation shall be satisfied with respect to the particular type of Award. 
 Section 14.9 Unfunded Plan. The adoption of the Plan and any reservation of shares of Common Stock or cash amounts by the Company to discharge its obligations hereunder shall not be
deemed to create a trust or other funded arrangement. Except upon the issuance of Common Stock pursuant to an Award, any rights of a Participant under the Plan shall be those of a general unsecured creditor of the Company, and neither a
Participant nor the Participant’s permitted transferees or estate shall have any other interest in any assets of the Company by virtue of the Plan. Notwithstanding the foregoing, the Company shall have the right to implement or set aside
funds in a grantor trust, subject to the claims of the Company’s creditors or otherwise, to discharge its obligations under the Plan. 
 Section 14.10 Other Compensation and Benefit Plans. The adoption of the Plan shall not affect any other stock incentive or other compensation plans in effect for the Company or any
Subsidiary, nor shall the Plan preclude the Company from establishing any other forms of stock incentive or other compensation or benefit program for employees of the Company or any Subsidiary. The amount of any compensation deemed to be
received by a Participant pursuant to an Award shall not constitute includable compensation for purposes of determining the amount of benefits to which a Participant is entitled under any other compensation or benefit plan or program of the Company
or any Subsidiary, including, without limitation, under any bonus, pension, profit-sharing, life insurance, salary continuation or severance benefits plan, except to the extent specifically provided by the terms of any such plan. 

Section 14.11 Plan Binding on Transferees. The Plan shall be binding upon the Company, its transferees and assigns,
and the Participant, the Participant’s executor, administrator and permitted transferees and beneficiaries. 

 Section 14.12 Severability. If any provision of the Plan or any Award
Agreement shall be determined to be illegal or unenforceable by any court of law in any jurisdiction, the remaining provisions hereof and thereof shall be severable and enforceable in accordance with their terms, and all provisions shall remain
enforceable in any other jurisdiction. 
 Section 14.13 Foreign Jurisdictions. The Committee may adopt, amend
and terminate such arrangements and grant such Awards, not inconsistent with the intent of the Plan, as it may deem necessary or desirable to comply with any tax, securities, regulatory or other laws of other jurisdictions with respect to Awards
that may be subject to such laws. The terms and conditions of such Awards may vary from the terms and conditions that would otherwise be required by the Plan solely to the extent the Committee deems necessary for such purpose. Moreover, the
Board may approve such supplements to or amendments, restatements or alternative versions of the Plan, not inconsistent with the intent of the Plan, as it may consider necessary or appropriate for such purposes, without thereby affecting the terms
of the Plan as in effect for any other purpose. 
 Section 14.14 Substitute Awards in Corporate Transactions.
Nothing contained in the Plan shall be construed to limit the right of the Committee to grant Awards under the Plan in connection with the acquisition, whether by purchase, merger, consolidation or other corporate transaction, of the business or
assets of any corporation or other entity. Without limiting the foregoing, the Committee may grant Awards under the Plan to an employee or director of another corporation who becomes an Eligible Person by reason of any such corporate
transaction in substitution for awards previously granted by such corporation or entity to such person. The terms and conditions of the substitute Awards may vary from the terms and conditions that would otherwise be required by the Plan solely
to the extent the Committee deems necessary for such purpose. Any shares of Common Stock subject to these substitute Awards shall not be counted against any of the maximum share limitations set forth in the Plan. 

Section 14.15 Governing Law. The Plan and all rights hereunder shall be subject to and interpreted in accordance with
the laws of the State of Delaware, without reference to the principles of conflicts of laws, and to applicable Federal securities laws. 
 Section 14.16 Section 409A Compliance. To the extent applicable, it is intended that the Plan and all Awards hereunder comply with the requirements of Section 409A of the
Code, and the Plan and all Award Agreements shall be interpreted and applied by the Committee in a manner consistent with this intent in order to avoid the imposition of any additional tax under Section 409A of the Code. In the event that
any provision of the Plan or an Award Agreement is determined by the Committee to not comply with the applicable requirements of Section 409A of the Code, the Committee shall have the authority to take such actions and to make such
interpretations or changes to the Plan or an Award Agreement as the Committee deems necessary to comply with such requirements, provided that the Committee shall act in a manner that is intended to preserve the economic value of the Award to the
Participant. Notwithstanding the foregoing or anything elsewhere in the Plan or an Award Agreement to the contrary, if a Participant is a “specified employee” as defined in Section 409A of the Code at the time of termination of
Service with respect to an Award, then solely to the extent necessary to avoid the imposition of any additional tax under Section 409A of the Code, the commencement of any payments or benefits under the Award shall be deferred until the date
that is six months following the Participant’s termination of Service (or such other period as required to comply with Section 409A). 
  

	15.	EFFECTIVE DATE; AMENDMENT AND TERMINATION 

 Section 15.1 Effective Date. The Plan became effective following its adoption by the Board and its approval by the Company’s stockholders on the date of the 2005 Annual Meeting of
Stockholders. The term of the Plan shall be ten (10) years from the date of such adoption by the Board, subject to Section 15.3 hereof. The Plan as amended and restated herein became effective following its adoption by the Board
and its approval by the Company’s stockholders on the date of the 2007 Annual Meeting of Stockholders. 

 Section 15.2 Amendment. The Board may at any time and from time to time
and in any respect, amend or modify the Plan. The Board may seek the approval of any amendment or modification by the Company’s stockholders to the extent it deems necessary or advisable in its discretion for purposes of compliance with
section 162(m) or section 422 of the Code, the listing requirements of the NASDAQ or other exchange or securities market or for any other purpose. No amendment or modification of the Plan shall adversely affect any Award theretofore granted
without the consent of the Participant or the permitted transferee of the Award. Notwithstanding the foregoing and notwithstanding anything to the contrary in the Plan, the Board may amend the Plan and any outstanding Award Agreement solely to
comply with any new regulations or other guidance from the Internal Revenue Service under section 409A of the Code without the consent of the Participant or the permitted transferee of the Award. 

Section 15.3 Termination. The Plan shall terminate on April 4, 2015, which is the date immediately preceding the
tenth anniversary of the date of the Plan’s adoption by the Board. The Board may, in its discretion and at any earlier date, terminate the Plan. Notwithstanding the foregoing, no termination of the Plan shall adversely affect any
Award theretofore granted without the consent of the Participant or the permitted transferee of the Award.

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