Document:

Employment Agreement

    Exhibit
      10.30

    

       

       

      EXECUTIVE
        EMPLOYMENT AGREEMENT

       

      Aspreva
        Pharmaceuticals Inc

       

      

       

      

       

      PRIVATE
        AND CONFIDENTIAL

       

      23
        September
        2004

      

      Charles
        F. Goulburn 

      346
        Mount Prospect Road

      Far
        Hills, New Jersey, 07931

      

      Dear
        Rick:

       

      
        	
                Re:

              	
                Terms
                  of Employment with Aspreva Pharmaceuticals
                  Inc

              

      

       

      This
        Agreement confirms the terms and conditions of your employment by Aspreva
        Pharmaceuticals Inc (the “Corporation”)
        and will constitute your employment agreement
        (the “Agreement”).
        Those terms and conditions are set out below. We also seek to complete
        pre-employment, an appropriate medical check, drug screen and criminal
        check.

       

      
        	
                1.

              	
                Position
                  and Duties.
                  You will be employed by and will serve the Corporation as its General
                  Manager
                  (USA),
                  and you hereby accept such employment. You will perform such
                  duties and functions customarily associated
                  with your then current title, consistent with the Bylaws of the
                  Company
                  and as required by the Company’s Board of
                  Directors (the “Board”),
                  including those duties and functions particularly described in
                  Schedule
                  A attached
                  to this Agreement. You will initially report directly to the
                  President
                  of Aspreva Pharmaceuticals Corporation.
                  Your duties and functions pertain to the Corporation and any of
                  its
                  parents
                  and subsidiaries
                  from time to time and may be varied or added to from time to time
                  by the
                  President, the Chief Executive Officer or the Board, at its discretion,
                  exercised reasonably.
                  Your primary office location shall be based in New Jersey, (the
                  final
                  location to be determined). The Corporation reserves the right
                  to
                  reasonably require you to perform your duties at places other than
                  its
                  corporate headquarters from time to time, and to require reasonable
                  business travel. The employment relationship between the parties
                  shall
                  also be governed by the general employment policies and practices
                  of the
                  Company, including those relating to protection of confidential
                  information and assignment of inventions, except that when the
                  terms of
                  this Agreement differ from or are in conflict with the Company’s general
                  employment policies or practices, this Agreement shall control.

              

      

       

      
        	
                2.

              	
                Term.
                  The terms and conditions of this Agreement shall have effect as
                  of and
                  from 18th
                  October, 2004 (the “Effective
                  Date”)
                  and your employment hereunder
                  shall continue unless
                  terminated prior thereto by either the Corporation or you as provided
                  herein. 

              

      

       

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      
        	
                3.

              	
                Base
                  Salary.
                  The Corporation shall pay you an
                  annualized base
                  salary at the rate of US $250,000
                  per year (the “Base
                  Salary”),
                  payable semi-monthly, subject to payroll
                  withholding and deductions.
                  

              

      

       

      
        	
                4.

              	
                Annual
                  Review.
                  The compensation committee (the “Compensation
                  Committee”)
                  established by the Board for
                  the purposes of this Agreement shall review your Base Salary annually.
                  This review shall not result in a decrease of your Base Salary
                  nor shall
                  it necessarily result in an increase in your Base Salary and any
                  increase
                  shall be in the discretion of the Board.

              

      

       

      
        	
                5.

              	
                Performance
                  Bonus.
                  The Corporation shall review the performance of your duties and
                  functions
                  under this Agreement annually.
                  You will be eligible for an annual bonus
                  in
                  an amount to be determined by the Board in its sole discretion
                  of
                  up to 30% of your Base Salary,
                  if the Board, in its sole discretion,
                  determines that the Corporation has met its short-term and long-term
                  business performance objectives and
                  you have met
                  objectives related to your personal performance (together, the
                  “Objectives”),
                  respectively weighted 40% and 60%.
                  The
                  Objectives will be established from time to time by the President
                  or Chief
                  Executive Officer in consultation with you. For
                  the remainder of 2004, you will be eligible for a pro-rated performance
                  bonus, based on initial performance against objectives, from the
                  Effective
                  Date. Payment of any performance
                  bonus set out in this Section 5 shall be made to you within a reasonable
                  time following the end of each fiscal year and
                  shall be subject to payroll
                  withholding and
                  deductions.
                  

              

      

       

      
        	
                6.

              	
                Benefits.
                   You
                  shall be entitled to all rights and benefits for which you are
                  eligible
                  under the terms and conditions of the standard Corporation benefits
                  and
                  compensation practices which may be in effect from time to time
                  and
                  provided by the Corporation to its employees generally.
                  These will include, health cover, dental cover, life assurance,
                  short and
                  long term disability. You may be required to provide information
                  and
                  undergo reasonable assessments of the insurers in order to determine
                  your
                  eligibility for benefits coverage. Please note that coverage under
                  any
                  benefit plan in effect from time to time is subject to availability
                  and
                  other requirements of the applicable insurer
                  and plan. The Corporation reserves the right to change, alter,
                  or
                  terminate any benefit plan in its sole discretion. If
                  in the short term you are required to use COBRA cover, the company
                  will
                  reimburse any relevant costs.

              

      

       

      
        	
                7.

              	
                Vacation.
                  During your employment with the Corporation under this Agreement,
                  you will
                  be entitled to an annual paid vacation as determined by the Corporation
                  from time to time, at
                  a rate of
                  20 days
                  per annum. The Corporation reserves the right, acting reasonably,
                  to
                  request that vacations be scheduled so as not to conflict with
                  critical
                  business operations. 

              

      

       

      
        
          
          

        

        
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                8.

              	
                Reimbursement
                  for Expenses.
                  During your employment under this Agreement, the Corporation shall
                  reimburse you for reasonable travelling and other expenses actually
                  and
                  properly incurred by you in connection with the performance of
                  your duties
                  and functions, such reimbursement to be made in accordance with,
                  and
                  subject to, the policies of the Corporation from time to time.
                  For all
                  such expenses you will be required to keep proper accounts and
                  to furnish
                  statements, vouchers, invoices and/or other supporting documents
                  to the
                  Corporation within 30 days after the date the expenses are
                  incurred.

              

      

       

      
        	
                9.

              	
                Stock
                  Options.
                  You will be eligible to receive a
                  grant of an option to purchase 100,000
                  shares
                  of common stock in Aspreva Pharmaceuticals Corporation (the “Option”)
                  at an exercise price and on such other terms set forth in the Aspreva
                  2002
                  Incentive Stock Option Plan
                  (the “Plan”),
                  subject to approval of the Board of
                  Aspreva Pharmaceuticals Corporation and
                  applicable securities regulatory authorities and to execution and
                  delivery
                  by you of a stock option agreement in a form acceptable to Aspreva
                  Pharmaceuticals Corporation. Except as otherwise provided herein,
                  no
                  Option will vest and become exercisable during
                  the first year following the Effective Date ("First Anniversary
                  Date"),
                  and thereafter one thirty-sixth (1/36th)
                  of the options vest at the end of each month for the next 36 months
                  commencing at the end of the first month following the First Anniversary
                  Date. Thus the total grant will vest and become exercisable over
                  a four (4) year period, in accordance with the Corporation’s standard
                  vesting and exercisability policy, as long as you remain in continuous
                  service with the Corporation. The Option shall be governed by the
                  terms
                  and conditions set forth in the Plan, the applicable stock option
                  agreement, and the grant document.

              

      

       

      The
        options granted in this Section 9 will cease to vest
        on the earlier of the following: 

       

      
        	 	
                (a)

              	
                on
                  the date you provide the Corporation with written notice of your
                  decision
                  to resign your employment pursuant to Section 14 (Termination by
                  Executive);

              

      

       

      
        	 	
                (b)

              	
                on
                  the date the Corporation provides you with written notice of its
                  decision
                  to terminate your employment pursuant to Section 15 (Termination
                  without
                  Cause);

              

      

       

      
        	 	
                (c)

              	
                on
                  the date the Corporation terminates your employment pursuant to
                  Section 16
                  (Termination for Cause);

              

      

       

      
        	 	
                (d)

              	
                otherwise
                  on the date this Agreement is terminated or deemed terminated;
                  or 

              

      

       

      
        	 	
                (e)

              	
                as
                  provided by the Plan or the stock option
                  agreement.

              

      

       

      For
        greater certainty; neither the period of notice nor any payment in lieu thereof
        will be considered as extending the period of your employment with respect
        to
        the vesting or exercise of the options granted in this Section 9. 

       

      Additionally,
        any option granted under the terms of the “Plan”, where your employment is
        terminated under Section 15 (Termination without Cause, or Section 14
        (Termination by Executive) clause 6.5 (b) will apply and you will have no
        more
        than (3) three months to exercise any vested options, before the option expires.
        

       

      
        
          
          

        

        
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                10.

              	
                Compliance
                  with Insider Trading Guidelines and Restrictions.
                  As a result of your position as General
                  Manager
                  you are subject to insider trading regulations and restrictions
                  and are
                  required to file insider reports disclosing the grant of any options
                  as
                  well as the purchase and sale of any shares in the capital of Aspreva
                  Pharmaceutical Corporation. Aspreva Pharmaceutical Inc or Aspreva
                  Pharmaceutical
                  Corporation may from time to time publish trading guidelines and
                  restrictions for its employees, officers and directors as are considered
                  by the Board, or
                  the Board of Aspreva Pharmaceutical Corporation, in
                  its discretion.
                  It is a term of your employment as a senior officer of Aspreva
                  Pharmaceutical Inc
                  that you comply with such guidelines and restrictions.
                  

              

      

       

      
        	
                11.

              	
                Directors’
                  & Officers’ Liability Insurance
                  and Indemnification.
                  The Corporation shall use commercially reasonable efforts to provide
                  you
                  with directors’ and officers’ liability insurance under the policies for
                  such insurance arranged by the Corporation from time to time upon
                  such
                  terms and in such amounts as the Board may reasonably determine
                  in its
                  discretion.
                  You shall enjoy the same indemnification rights provided to other
                  officers
                  of the Corporation, as set forth in the Bylaws of the Corporation.
                  

              

      

       

      
        	
                12.

              	
                No
                  Other Compensation or Benefits.
                  You expressly acknowledge and agree that unless otherwise expressly
                  agreed
                  in writing by the Corporation subsequent to execution of this Agreement
                  by
                  the parties hereto, you shall not be entitled by reason of your
                  employment
                  by the Corporation or by reason of any termination of such employment,
                  to
                  any remuneration, compensation or benefits other than as expressly
                  set
                  forth in this Agreement.

              

      

       

      
        	
                13.

              	
                Service
                  to Employer.
                  During your employment under this Agreement you
                  will:

              

      

       

      
        	 	
                (a)

              	
                well
                  and faithfully serve the Corporation, at all times act in, and
                  promote,
                  the best interests of the Corporation, and devote substantially
                  the whole
                  of your working time, attention and energies to the business and
                  affairs
                  of the Corporation;

              

      

       

      
        	 	
                (b)

              	
                comply
                  with all rules, regulations, policies and procedures of the Corporation;
                  

              

      

       

      
        	 	
                (c)

              	
                not,
                  without the prior approval of the Board, carry on or engage in
                  any other
                  business or occupation or become a director, officer, employee
                  or agent of
                  or hold any position or office with any other corporation, firm
                  or
                  person;
                  provided, however, that you may serve
                  as a volunteer for a non-profit organization
                  so long as such activities for not materially interfere with the
                  performance of your duties hereunder.

              

      

       

      
        
          
          

        

        
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                14.

              	
                Termination
                  By Executive

              

      

       

      
        	 	
                (a)

              	
                You
                  may terminate
                  your employment hereunder,
                  on giving 1 month’s
                  prior
                  written notice of the effective date of your resignation. On the
                  giving of
                  any such notice, the Corporation shall have the right to elect,
                  in lieu of
                  the notice period, to pay you a lump sum equal to 1 month’s
                  Base Salary, as referred to in Section 3 (Base Salary) and as adjusted
                  from time to time in accordance with Section 4 (Annual Review),
                  plus other
                  sums owed for arrears of salary, vacation pay and, if granted pursuant
                  to
                  Section 5 (Performance Bonus),
                  bonus.

              

      

       

      
        	 	
                (b)

              	
                If
                  the Corporation elects to pay you such lump sum in lieu of the
                  1
                  month’s
                  notice
                  period, the Corporation shall, subject to the terms and conditions
                  of any
                  benefit plans in effect from time to time, maintain the benefits
                  and
                  payments set out in Section 6 (Benefits) of this Agreement for
                  1
                  month
                  after the date of your notice, to
                  the extent provided by the plans and applicable law, but
                  in all other respects, your resignation and the termination of
                  your
                  employment will be effective immediately upon notice
                  by the Corporation that it will pay you
                  the lump sum
                  in lieu of the notice period.

              

      

       

      
        	
                15.

              	
                Termination
                  by the Corporation Without Cause.
                  

              

      

       

      
        	 	
                (a)

              	
                The
                  Corporation may terminate your employment at
                  any time without Cause (as defined below) by giving you written
                  notice of
                  the effective date of such termination and in all respects, except
                  as set
                  out below, the
                  termination of your employment will be effective
                  immediately.

              

      

       

      
        	 	
                (b)

              	
                If
                  your employment is terminated by the Corporation pursuant to this
                  Section,
                  unless otherwise determined by the Board, the Corporation shall
                  pay
                  severance payments in the form of a (1) a lump sum payment
                  to you equal to 6 months, plus one
                  additional
                  month for each completed year of employment (measured on the anniversary
                  of the Effective Date), of Base Salary, as referred to in Section
                  3 (Base
                  Salary)
                  and as adjusted from time to time in accordance with Section 4
                  (Annual
                  Review), up to a total maximum number of twelve months;
                  and
                  (2) if you timely elect and remain eligible for continued coverage
                  under
                  COBRA, the Company, as part of this Agreement, will pay that portion
                  of
                  your group health insurance premiums it was paying prior to the
                  date of
                  the termination or your employment towards your COBRA premiums
                  for the
                  first six months following the date of termination of your employment.
                  Such payments will only be made, however, if sign
                  and make effective a full, general release of all claims against
                  the
                  Corporation in a form acceptable to the Corporation in order to
                  receive
                  such payment. You will also receive such
                  sums owed for arrears of salary, vacation pay and, if granted pursuant
                  to
                  Section 5 (Performance Bonus), bonus.  

              

      

       

      
        	 	
                (c)

              	
                You
                  are not entitled to any notice period under this Section 15.
                  

              

      

       

      
        
          
          

        

        
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                16.

              	
                Termination
                  by the Corporation for Cause.
                  Notwithstanding Section 14 (Termination by Executive) or Section
                  15
                  (Termination by the Corporation without Cause), the Corporation
                  may
                  terminate your employment
                  for Cause at any time without any notice or severance. In this
                  Agreement,
                  “Cause”
                  shall include, but not be limited to, the
                  following:

              

      

       

      
        	 	
                (a)

              	
                the
                  commission of theft, embezzlement, fraud, obtaining funds or property
                  under false pretences or similar acts of misconduct with respect
                  to the
                  property of the Corporation or its employees or the Corporation’s
                  customers or suppliers; your
                  entering of a guilty plea or
                  your
                  conviction for any crime involving fraud, misrepresentation or
                  breach of
                  trust, or your
                  entering a guilty plea or your conviction for
                  any serious criminal offence that impacts adversely on the Corporation;
                  breach
                  of your duties to the Corporation;

              

      

       

      
        	 	
                (b)

              	
                persistent
                  unsatisfactory performance of your job duties after written notice
                  from
                  the Board and a reasonable opportunity to cure, if possible;
                  

              

      

       

      
        	 	
                (c)

              	
                intentional
                  damage to any property of the
                  Corporation;

              

      

       

      
        	 	
                (d)

              	
                conduct
                  by you which in the good faith and reasonable determination of
                  the Board
                  demonstrates gross unfitness to serve;

              

      

       

      
        	 	
                (e)

              	
                incapacity
                  to perform the essential functions of your job for a period of
                  ninety (90)
                  calendar days, or for at least sixty-five (65) business days within
                  a
                  twelve (12)-month period; 

              

      

       

      
        	 	
                (f)

              	
                death;
                  or.

              

      

       

      
        	 	
                (g)

              	
                any
                  other matter constituting just cause at common
                  law.

              

      

       

      any
        of which shall entitle the Corporation to terminate your employment under
        this
        Section 16.

       

      
        	
                17.

              	
                No
                  Additional Compensation upon Termination.
                  It is agreed that
                  you shall
                  not,
                  as a result of the termination of your employment, be entitled
                  to any
                  notice, fee, salary, bonus, severance or other payments, benefits
                  or
                  damages arising by virtue of, or in any way relating to, your employment
                  or any other relationship with the Corporation (including termination
                  of
                  such employment or relationship) in excess of what is specified
                  or
                  provided for in Section 14 (Termination by Executive), Section
                  15
                  (Termination by the Corporation Without Cause) or Section 16 (Termination
                  by the Corporation for Cause), whichever is applicable. Payment
                  of any
                  amount whatsoever pursuant to Section 14 (Termination by Executive)
                  or
                  Section 15 (Termination by the Corporation without Cause) shall
                  be subject
                  to payroll
                  withholding and
                  deductions.

              

      

       

      
        
          
          

        

        
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                18.

              	
                Termination
                  Following Change in Control.
                  You may terminate your employment following a Change of Control
                  of the
                  Corporation, as defined in the Aspreva 2002 Incentive Stock Option
                  Plan,
                  at any time during the term of this Agreement, upon the occurrence
                  of an
                  "Activation
                  Event."
                  For purposes of this Agreement, an "Activation
                  Event"
                  shall mean any of the following events after a Change of Control:
                  (1) your
                  assignment without express written approval, of duties inconsistent
                  with
                  your position, duties, responsibilities, titles, offices or status
                  with
                  the Corporation immediately prior to the Change of Control, or
                  your
                  removal from the General Manager (USA) position; ; (2) a material
                  reduction, in the aggregate, in your Base Salary, or incentive,
                  health
                  benefits, bonus or other compensation plans in effect immediately
                  prior to
                  the Change of Control; (3) any request by the Corporation or any
                  other
                  affiliate of the Corporation that you participate in an unlawful
                  act; ;
                  (4) the failure of the Corporation to provide you with benefits
                  at levels
                  that were applicable to you immediately prior to the Change of
                  Control;
                  (5) your involuntary relocation to any place other than the location
                  at
                  which you performed your duties, except for your required travel
                  on the
                  Corporation's business to an extent substantially consistent with
                  your
                  business travel obligations immediately prior to a Change of Control;
                  (6)
                  any purported termination of your employment that is not effected
                  pursuant
                  to this Agreement.

              

      

       

      
        	
                19.

              	
                Confidentiality
                  and Assignment of Inventions.
                  Concurrently with execution and delivery of this Agreement and
                  in
                  consideration of your employment by the Corporation, you and the
                  Corporation will enter into a “Confidentiality
                  Agreement and Assignment of Inventions”
                  in the form attached hereto as Schedule
                  B.

              

      

       

      
        	
                20.

              	
                Disclosure
                  of Conflicts of Interest.
                  During your employment with the Corporation, you will promptly,
                  fully and
                  frankly disclose to the Corporation in
                  writing:

              

      

       

      
        	 	
                (a)

              	
                the
                  nature and extent of any interest you or your Associates (as hereinafter
                  defined) have or may have, directly or indirectly, in any contract
                  or
                  transaction or proposed contract or transaction of or with the
                  Corporation
                  or any subsidiary or affiliate of the
                  Corporation;

              

      

       

      
        	 	
                (b)

              	
                every
                  office you may hold or acquire, and every property you or your
                  Associates
                  may possess or acquire, whereby directly or indirectly a duty or
                  interest
                  might be created in conflict with the interests of the Corporation
                  or your
                  duties and obligations under this Agreement;
                  and

              

      

       

      
        	 	
                (c)

              	
                the
                  nature and extent of any conflict referred to in subsection (b)
                  above.

              

      

       

      In
        this Agreement, “Associates”
        shall include all those persons and entities with or in whom you have a
“Substantial
        Financial Interest.”
        Substantial Financial Interest is defined as (i) more than 1% stake in a
        publicly traded company; (ii) a stake which constitutes greater than 5% of
        your
        assets; or (iii) a venture capital investment of any amount. Associates shall
        also include your spouse, children, parents, brothers and sisters.

       

      You
        further represent and warrant that your employment by the Corporation will
        not
        conflict with any prior employment or consulting agreement or other agreement
        with any 

       

      
        
          
          

        

        
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      third
        party, and that you will perform your duties to the Corporation without
        violating any such agreement. You represent and warrant that you do not possess
        confidential information arising out of prior employment, consulting, or
        other
        third party relationships, which would be used in connection with your
        employment by the Corporation, except as expressly authorized by that third
        party. During your employment by the Corporation, you will use in the
        performance of your duties only information that is generally known and used
        by
        persons with training and experience comparable to your own, common knowledge
        in
        the industry, otherwise legally in the public domain, or obtained or developed
        by the Corporation or by you in the course of your work for the Corporation.
        

       

      
        	
                21.

              	
                Avoidance
                  of Conflicts of Interest.
                  You acknowledge that it is the policy of the Corporation that all
                  interests and conflicts of the sort described in Section 20 (Disclosure
                  of
                  Conflicts of Interest) be avoided, and you agree to comply with
                  all
                  policies and directives of the Board from time to time regulating,
                  restricting or prohibiting circumstances giving rise to interests
                  or
                  conflicts of the sort described in Section 20 (Disclosure of Conflicts
                  of
                  Interest). During your employment with the Corporation, without
                  Board
                  approval, in its sole discretion, you shall not enter into any
                  agreement,
                  arrangement or understanding with any other person or entity that
                  would in
                  any way conflict or interfere with this Agreement or your duties
                  or
                  obligations under this Agreement or that would otherwise prevent
                  you from
                  performing your obligations hereunder, and you represent and warrant
                  that
                  you or your Associates have not entered into any such agreement,
                  arrangement or understanding.

              

      

       

      
        	
                22.

              	
                Remedies.
                  You acknowledge and agree that any breach or threatened breach
                  of any of
                  the provisions of Section 10 (Compliance with Insider Trading and
                  Guidelines and Restrictions), Section 13 (Service to Employer),
                  Section 19
                  (Confidentiality and Assignment of Inventions), Section 20 (Disclosure
                  of
                  Conflicts of Interest)
                  or
                  Section 21 (Avoidance of Conflicts of Interest) could
                  cause irreparable damage to the Corporation or its partners, parents,
                  subsidiaries
                  or affiliates, that such harm could not be adequately compensated
                  by the
                  Corporation’s recovery of monetary damages, and that in the event of a
                  breach or threatened breach thereof, the Corporation shall have
                  the right
                  to seek an injunction, specific performance or other equitable
                  relief as
                  well as any equitable accounting of all your profits or benefits
                  arising
                  out of any such breach. It is further acknowledged and agreed that
                  the
                  remedies of the Corporation specified in this Section 22
                  are in addition to and not in substitution for any rights or remedies
                  of
                  the Corporation at law or in equity and that all such rights and
                  remedies
                  are cumulative and not alternative and that the Corporation may
                  have
                  recourse to any one or more of its available rights or remedies
                  as it
                  shall see fit. 

              

      

       

      
        
          
          

        

        
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                23.

              	
                Binding
                  Effect.
                  This Agreement shall be binding upon and inure to the benefit of
                  the
                  Corporation and its successors and assigns. Your rights and obligations
                  contained in this Agreement are personal and such rights, benefits
                  and
                  obligations shall not be voluntarily or involuntarily assigned,
                  alienated
                  or transferred, whether by operation of law or otherwise, without
                  the
                  prior written consent of the Corporation. This Agreement shall
                  otherwise
                  be binding upon and inure to the benefit of your personal or legal
                  representatives, executors, administrators, successors, heirs,
                  distributees, devisees, legatees and permitted assigns. 

              

      

       

      
        	
                24.

              	
                Agreement
                  Confidential.
                  You
                  shall keep the terms and conditions of this Agreement confidential
                  except
                  as may be required to enforce any provision of this Agreement or
                  as may
                  otherwise be required by any law, regulation or other regulatory
                  requirement.

              

      

       

      
        	
                25.

              	
                Governing
                  Law.
                  This Agreement shall be governed by and interpreted in accordance
                  with the
                  laws of the State
                  of New Jersey as such laws are applied to agreements entered into
                  and to
                  be performed entirely within New Jersey between New Jersey residents.
                  You
                  hereby expressly consent to the personal jurisdiction of the
                  state
                  and federal courts located
                  in New Jersey for any lawsuit filed there against you by the Corporation
                  arising from or related to this Agreement.

              

      

       

      
        	
                26.

              	
                Exercise
                  of Functions.
                  The rights of the Corporation as provided in this Agreement may
                  be
                  exercised on behalf of the Corporation only by the Board (excluding
                  you).

              

      

       

      
        	
                27.

              	
                Entire
                  Agreement.
                  The terms and conditions of this Agreement and
                  its exhibits are
                  in addition to and not in substitution for the obligations, duties
                  and
                  responsibilities imposed by law on employees of corporations generally,
                  and you agree to comply with such obligations, duties and
                  responsibilities. Except as otherwise provided in this Agreement,
                  this
                  Agreement and
                  its exhibits constitute
                  the entire agreement between the parties with respect to the subject
                  matter hereof, and may only be varied by further written agreement
                  signed
                  by you and the Corporation. This Agreement supersedes any previous
                  communications, understandings and agreements between you and the
                  Corporation regarding your employment. It is acknowledged and agreed
                  that
                  this Agreement is mutually beneficial and is entered into for valuable
                  consideration with the intent that it shall constitute a legally
                  binding
                  agreement.

              

      

       

      
        	
                28.

              	
                Further
                  Assurances.
                  The parties will execute and deliver to each other such further
                  instruments and assurances and do such further acts as may be required
                  to
                  give effect to this Agreement.

              

      

       

      
        	
                29.

              	
                Surviving
                  Obligations.
                  Your obligations and covenants under Section 17 (No Additional
                  Compensation upon Termination), Section 19 (Confidentiality and
                  Assignment
                  of Inventions),
                  Section 22
                  (Remedies), Section 23 (Binding Effect), Section 24 (Agreement
                  Confidential), Section 25 (Governing Law), Section 27 (Entire Agreement)
                  and Section 33 (Waiver) shall survive the termination of this
                  Agreement.

              

      

       

      
        
          
          

        

        
          -
            9
            -

          
            

          

        

        
          
          

        

      

       

      
        	
                30.

              	
                Independent
                  Legal Advice.
                  You hereby acknowledge that you have obtained (at your own cost)
                  or have
                  had an opportunity to obtain independent legal advice in connection
                  with
                  this Agreement, and further acknowledge that you have read, understand,
                  and agree to be bound by all of the terms and conditions contained
                  herein.

              

      

       

      
        	
                31.

              	
                Notice.
                  Any notice or other communication required or contemplated under
                  this
                  Agreement to be given by one party to the other shall be delivered
                  personally,
                  by overnight delivery or
                  mailed by prepaid registered post to the party to receive same
                  at the
                  address as set out below:

              

      

       

      If
        to the Corporation: Aspreva
        Pharmaceuticals Inc

      C/o
        Aspreva Pharmaceuticals Corporation

      1203-4464
        Markham Rd, Victoria, BC, Canada. V8Z 7X8 

      or
        Aspreva Pharmaceuticals Corporation Corporate Headquarters address at the
        time
        notice is given 

      

      Attn:
        If
        to Charles
        F. Goulburn:

      Charles
        F. Goulburn 

      346
        Mount Prospect Road

      Far
        Hills, New Jersey, 07931

      or
        home address as shown in the Corporation’s records at the time notice is
        given

       

      Any
        notice delivered shall be deemed to have been given and received on
        the date of delivery. Any notice mailed shall be deemed to have been given
        and
        received on the fifth business day following the date it was posted, unless
        between the time of mailing and actual receipt of the notice.

       

      
        	
                32.

              	
                Severability.
                  If any provision of this Agreement or any part thereof shall for
                  any
                  reason be held to be invalid or unenforceable in any respect, then
                  such
                  invalid or unenforceable provision or part shall be severable and
                  severed
                  from this Agreement and the other provisions of this Agreement
                  shall
                  remain in effect and be construed as if such invalid or unenforceable
                  provision or part had never been contained
                  herein.

              

      

       

      
        	
                33.

              	
                Waiver.
                  Any waiver of any breach or default under this Agreement shall
                  only be
                  effective if in writing signed by the party against whom the waiver
                  is
                  sought to be enforced, and no waiver shall be implied by any other
                  act or
                  conduct or by any indulgence, delay or omission. Any waiver shall
                  only
                  apply to the specific matter waived and only in the specific instance
                  in
                  which it is waived.

              

      

       

      
        
          
          

        

        
          -
            10
            -

          
            

          

        

        
          
          

        

      

       

      
        	
                34.

              	
                Counterparts.
                  This Agreement may be executed in any number of counterparts, each
                  of
                  which so executed shall be deemed to be an original, and such counterparts
                  will together constitute but one
                  Agreement.

              

      

       

      If
        you accept and agree to the foregoing, please confirm your acceptance and
        agreement by signing the enclosed duplicate copy of this letter where indicated
        below and by returning it to us. You are urged to consider fully all the
        above
        terms and conditions and to obtain independent legal advice or any other
        advice
        you feel is necessary before you execute this agreement.

       

      
        	 	
                Yours
                  truly,

              
	 	 
	 	
                Aspreva
                  Pharmaceuticals Inc

              
	 	 
	 	 
	
                By: 

              	 
	    [Name]	 
	 	 
	 	 
	
                    [Title]

              	 
	 	 
	
                Accepted
                  and agreed to by Charles
                  F. Goulburn as
                  of the 23rd
                  day of September, 2004

              
	 
	/s/
                Charles F. Goulburn	 
	
                Charles
                  F. Goulburn

              	 

      

       

       

      

      
        
          
          

        

        
          -
            11
            -

          
            

          

        

        
          
          

        

      

       

       

      SCHEDULE
        B

       

      CONFIDENTIALITY
        AGREEMENT AND

      ASSIGNMENT
        OF INVENTIONS

       

       

      ASPREVA
        PHARMACEUTICALS INC

       

      

       

      PRIVATE
        AND CONFIDENTIAL

       

      23rd
        September, 2004

      Charles
        F. Goulburn 

      346
        Mount Prospect Road

      Far
        Hills, New Jersey, 07931

      

      Dear
        Rick:

       

      The
        purpose of this letter is to confirm and record the terms of the agreement
        (the
“Agreement”)
        between you and Aspreva Pharmaceuticals Incorporated (“Aspreva”)
        concerning, among other things, the terms on which you will (i) receive from
        and
        disclose to Aspreva proprietary and confidential information; (ii) agree
        to keep
        the information confidential, to protect it from disclosure and to use it
        only
        in accordance with the terms of this Agreement; (iii) assign to Aspreva all
        rights, including any ownership interest which may arise in all inventions
        and
        intellectual property developed or disclosed by you over the course of your
        work
        during your employment with Aspreva; and (iv) agree to certain restrictions
        on
        competitive activity. The effective date (“Effective
        Date”)
        of this Agreement is the date that you start or started working at Aspreva,
        as
        indicated in the employment agreement between you and Aspreva dated as of
        18th
        October, 2004.

       

      In
        consideration of the offer of employment by Aspreva and other good and valuable
        consideration, the receipt and sufficiency of which is hereby acknowledged,
        you
        and Aspreva hereby agree as follows:

       

      The
        following numbering is done with the Alt NB numbering macro. There are 6
        levels
        (Heading 1 to Heading 6 styles); shortcut keys Ctrl Alt 1 to Ctrl Alt 6.
        

       

      
        	
                1.

              	
                INTERPRETATION

              

      

      
         

        
          	
                  1.1

                	
                  Definitions. 
                    In this Agreement:

                

        

              

                     “Confidential
          Information”,
          subject to the exemptions set out in Section 2.8, shall mean any information,
          data, or knowledge of Aspreva and its affiliates, parents, and subsidiaries
          (for
          purposes of this definition of Confidential Information, “Aspreva”), including
          that which relates to Aspreva’s Business (as hereinafter defined), whether or
          not conceived, originated, discovered, or developed in whole or in part
          by you,
          that is not generally known to the public or 

         

        
          
            
            

          

          
            
            

            
              

            

          

          
            
            

          

        

         

        to
          other persons who are not bound by obligations of confidentiality. Confidential
          Information, without limiting the generality of the foregoing, shall
          include:

      

       

      
        	 	
                (i)

              	
                all
                  proprietary information licensed to, acquired, used or developed
                  by
                  Aspreva in its research and development activities including but
                  not
                  restricted to the development and commercialization of drugs for
                  rare
                  diseases and conditions and orphan drugs as defined by the U.S.
                  Orphan
                  Drug Act,
                  other scientific strategies and concepts, designs, know-how, information,
                  material, formulas, processes, research data and proprietary rights
                  in the
                  nature of copyrights, patents, trademarks, licenses and industrial
                  designs;

              

      

       

      
        	 	
                (ii)

              	
                all
                  information relating to Aspreva’s Business, and to all other aspects of
                  Aspreva’s structure, personnel, and operations, including financial,
                  clinical, regulatory, marketing, advertising and commercial information
                  and strategies, compilations, agreements and contractual records
                  and
                  correspondence, programs, devices, concepts, inventions, designs,
                  methods,
                  processes, data, know-how, unique combinations of separate items
                  that are
                  not generally known and items provided or disclosed to Aspreva
                  by third
                  parties subject to restrictions on use or
                  disclosure;

              

      

       

      
        	 	
                (iii)

              	
                all
                  information relating to customers, including names, lists,
                  representatives, their desires and needs with respect to the type
                  of
                  products and services offered by Aspreva;

              

      

       

      
        	 	
                (iv)

              	
                all
                  know-how relating to Aspreva’s Business including, all biological,
                  chemical, pharmacological, toxicological, pharmaceutical, physical
                  and
                  analytical, clinical, safety, manufacturing and quality control
                  data and
                  information, and all applications, registrations, licenses,
                  authorizations, approvals and correspondence submitted to regulatory
                  authorities;

              

      

       

      
        	 	
                (v)

              	
                all
                  information relating to the businesses of competitors of Aspreva
                  and its
                  affiliates, parents and subsidiaries, including information relating
                  to
                  competitors’ research and development, intellectual property, operations,
                  financial, clinical, regulatory, marketing, advertising and commercial
                  strategies, that is not generally known;

              

      

       

      
        	 	
                (vi)

              	
                all
                  information provided by Aspreva’s agents, consultants, lawyers,
                  contractors, licensors or licensees to Aspreva and relating to
                  Aspreva’s
                  Business; 

              

      

       

      
        	 	
                (vii)

              	
                all
                  information relating to compensation and benefits, including salary,
                  vacation, stock options, rights to continuing education, perquisites,
                  severance notice, rights on termination and all other compensation
                  and
                  benefits, except that you shall be entitled to disclose such information
                  as it relate to you to your bankers, advisors, agents, consultants
                  and
                  other third parties who have a duty of confidence to you and who
                  have a
                  need to know 

              

      

      
         

        
          
            
            

          

          
            - 2
              -

            
              

            

          

          
            
            

          

        

         

        
          	 	
                	
                  such
                    information in order to provide advice, products or services
                    to you; and
                    

                

        

      

      
      

       

      
        	 	
                (viii)

              	
                all
                  other information of Aspreva from which Aspreva derives economic
                  value,
                  actual or potential, from the information not being generally known;
                  or in
                  respect of which Aspreva otherwise has a legitimate interest in
                  maintaining secrecy.

              

      

       

      
        	 	
                (b)

              	
                “Inventions”
                  shall mean any and all discoveries, developments, enhancements,
                  improvements, inventions, concepts, ideas, formulas, processes,
                  ideas,
                  writings, whether or not reduced to practice, industrial and other
                  designs, patents, patent applications, provisional patent applications,
                  continuations, continuations-in-part, substitutions, divisionals,
                  reissues, renewals, re-examinations, extensions, supplementary
                  protection
                  certificates or the like, trade secrets or utility models, copyrights
                  and
                  other forms of intellectual property including all applications,
                  registrations and related foreign applications filed and registrations
                  granted thereon.

              

      

       

      
        	 	
                (c)

              	
                “Work
                  Product”
                  shall mean any and all Inventions and possible Inventions that
                  you may
                  invent, conceive or reduce to practice, either alone or jointly
                  with
                  others, during your involvement in any capacity with Aspreva; provided
                  that those Inventions invented by you entirely on your own time
                  that do
                  not relate to Aspreva’s Business or Aspreva’s anticipated business or
                  research or developments or do not derive from any equipment, supplies,
                  facilities, Confidential Information or other information, gained,
                  directly or indirectly, by you from or through your involvement
                  in any
                  capacity with Aspreva are not Work
                  Product.

              

      

       

      
        	 	
                (d)

              	
                “Aspreva’s
                  Business”
                  shall mean the businesses carried on by Aspreva and its affiliates,
                  parents and subsidiaries, directly or indirectly, whether under
                  an
                  agreement with or in collaboration with, any other party including
                  but not
                  exclusively, the development and commercialization of drugs for
                  rare
                  diseases and conditions and orphan drugs as defined by the U.S.
                  Orphan
                  Drug Act.

              

      

       

      
        	
                2.

              	
                CONFIDENTIALITY

              

      

       

      2.1                 Basic
        Obligation of Confidentiality.
        You hereby acknowledge and agree that in the course of your involvement with
        Aspreva, Aspreva or its affiliates, parents or subsidiaries may disclose
        to you
        or you may otherwise have access or be exposed to Confidential Information.
        You
        agree to receive and hold all Confidential Information on the terms and
        conditions set out in this Agreement. Except as set out in this Agreement,
        you
        will keep strictly confidential all Confidential Information and all other
        information belonging to Aspreva or its affiliates, parents and subsidiaries,
        that you acquire, observe or are informed of, directly or indirectly, in
        connection with your involvement, in any capacity, with Aspreva.

       

      2.2                 Fiduciary
        Capacity.
        You will be and act toward Aspreva as a fiduciary in respect of the Confidential
        Information.

       

      
        
          
          

        

        
          - 3
            -

          
            

          

        

        
          
          

        

      

       

      2.3                 Non-disclosure.
        Unless Aspreva first gives you written permission to do so under Section
        2.7 of
        this Agreement, you will not at any time, either during or after your
        involvement in any capacity with Aspreva;

       

      
        	 	
                (a)

              	
                use
                  or copy Confidential Information or your recollections thereof;
                  

              

      

       

      
        	 	
                (b)

              	
                publish
                  or disclose Confidential Information or your recollections thereof
                  to any
                  person other than to employees of Aspreva or its affiliates, parents,
                  and
                  subsidiaries who have a need to know such Confidential Information
                  for
                  their work for Aspreva; 

              

      

       

      
        	 	
                (c)

              	
                permit
                  or cause any Confidential Information to be used, copied, published,
                  disclosed, translated or adapted except as otherwise expressly
                  permitted
                  by this Agreement;

              

      

       

      
        	 	
                (d)

              	
                permit
                  or cause any Confidential Information to be stored off the premises
                  of
                  Aspreva, including permitting or causing such Information to be
                  stored in
                  electronic format on personal computers, except in accordance with
                  written
                  procedures of Aspreva, as amended from time to time in writing;
                  or

              

      

       

      
        	 	
                (e)

              	
                communicate
                  the Confidential Information or your recollections thereof to another
                  employee of Aspreva in a public place or using methods of communication
                  that are capable of being intercepted (such as unencrypted messages
                  using
                  the internet or cellular phones) or overheard, without the written
                  permission of Aspreva.

              

      

       

      2.4                 Third
        Party Information.
        You understand, in addition, that Aspreva has received and in the future
        will
        receive from third parties their confidential and/or proprietary knowledge,
        data, or information (“Third
        Party Information”).
        During my employment and thereafter, you will hold Third Party Information
        in
        the strictest confidence. You will not disclose to anyone (other than Aspreva
        personnel who need to know such information in connection with their work
        for
        Aspreva) or use, except in connection with my work for Aspreva, Third Party
        Information unless expressly authorized by an officer of Aspreva in
        writing

       

      2.5                 Taking
        Precautions.
        You will take all reasonable precautions necessary or prudent to prevent
        material in your possession or control that contains or refers to Confidential
        Information from being discovered, used or copied by third parties.

       

      2.6                 Aspreva’s
        Ownership of Confidential Information.
        As between you and Aspreva, Aspreva shall own all right, title and interest
        in
        and to the Confidential Information, whether or not created or developed
        by
        you.

       

      2.7                 Control
        of Confidential Information and Return of Information.
        All physical materials produced or prepared by you containing Confidential
        Information, including, without limitation, biological material, chemical
        entities, test results, notes of experiments, computer files, photographs,
        x-ray
        film, designs, devices, formulas, memoranda, drawings, plans, prototypes,
        samples, accounts, reports, financial statements, estimates and materials
        prepared in the course of your responsibilities to or for the benefit of
        Aspreva, shall belong to Aspreva, and 

       

      
        
          
          

        

        
          - 4
            -

          
            

          

        

        
          
          

        

      

       

      you
        will promptly turn over to Aspreva’s possession every original and copy of any
        and all such items in your possession or control upon request by Aspreva.
        You
        shall not permit or cause any physical materials to be stored off the premises
        of Aspreva, unless in accordance with written procedures of Aspreva, as amended
        from time to time in writing. You shall not transfer any biological material
        to
        another person outside of Aspreva, unless a material transfer agreement has
        been
        signed by both Aspreva and the other party. You shall not accept any biological
        material from another person outside of Aspreva, unless in accordance with
        written procedures of Aspreva, as amended from time to time in
        writing.

       

      2.8                 Purpose
        of Use.
        You will use Confidential Information only for purposes authorised or directed
        by Aspreva.

       

      2.9                 Exemptions.
        Your obligation of confidentiality under this Agreement will not apply to
        any of
        the following:

       

      
        	 	
                (a)

              	
                information
                  that is already known to you, though not due to a prior disclosure
                  by
                  Aspreva or its affiliates, parents, and subsidiaries or by a person
                  who
                  obtained knowledge of the information, directly or indirectly,
                  from
                  Aspreva or its affiliates, parents, and
                  subsidiaries;

              

      

       

      
        	 	
                (b)

              	
                information
                  disclosed to you by another person who is not obliged to maintain
                  the
                  confidentiality of that information and who did not obtain knowledge
                  of
                  the information, directly or indirectly, from Aspreva or its affiliates,
                  parents, and subsidiaries;

              

      

       

      
        	 	
                (c)

              	
                information
                  that is developed by you independently of Confidential Information
                  received from Aspreva or its affiliates, parents, and subsidiaries
                  and
                  such independent development can be documented by
                  you;

              

      

       

      
        	 	
                (d)

              	
                other
                  particular information or material which Aspreva expressly exempts
                  by
                  written instrument signed by
                  Aspreva;

              

      

       

      
        	 	
                (e)

              	
                information
                  or material that is in the public domain through no fault of your
                  own;
                  and

              

      

       

      
        	 	
                (f)

              	
                information
                  or material that you are obligated by law to disclose, to the extent
                  of
                  such obligation, provided that:

              

      

       

      
        	 	
                (i)

              	
                in
                  the event that you are required to disclose such information or
                  material,
                  then, as soon as you become aware of this obligation to disclose,
                  you will
                  provide Aspreva with prompt written notice so that Aspreva may
                  seek a
                  protective order or other appropriate remedy and/or waive compliance
                  with
                  the provisions of this Agreement;

              

      

       

      
        	 	
                (ii)

              	
                if
                  Aspreva agrees that the disclosure is required by law, it will
                  give you
                  written authorization to disclose the information for the required
                  purposes only;

              

      

       

      
        
          
          

        

        
          - 5
            -

          
            

          

        

        
          
          

        

      

       

      
        	 	
                (iii)

              	
                if
                  Aspreva does not agree that the disclosure is required by law,
                  this
                  Agreement will continue to apply, except to the extent that a Court
                  of
                  competent jurisdiction orders otherwise;
                  and

              

      

       

      
        	 	
                (iv)

              	
                if
                  a protective order or other remedy is not obtained or if compliance
                  with
                  this Agreement is waived, you will furnish only that portion of
                  the
                  Confidential Information that is legally required and will exercise
                  all
                  reasonable efforts to obtain confidential treatment of such Confidential
                  Information.

              

      

       

      
        	
                3.

              	
                ASSIGNMENT
                  OF INTELLECTUAL PROPERTY
                  RIGHTS

              

      

       

      3.1                 Notice
        of Invention.
        You agree to promptly and fully inform Aspreva of all your Work Product,
        whether
        or not patentable, throughout the course of your involvement, in any capacity,
        with Aspreva, whether or not developed before or after your execution of
        this
        Agreement. On your ceasing to be employed by Aspreva for any reason whatsoever,
        you will immediately deliver up to Aspreva all of your Work Product. You
        further
        agree that all of your Work Product shall at all times be the Confidential
        Information of Aspreva.

       

      3.2                 Previous
        Inventions. Inventions,
        if any, patented or unpatented, which you made prior to the commencement
        of your
        involvement, in any capacity, with Aspreva, are excluded from the scope of
        this
        Agreement. To preclude any possible uncertainty, you must set forth on
Exhibit A
        (Previous
        Inventions) attached hereto a complete list of all Inventions that you have,
        alone or jointly with others, conceived, developed or reduced to practice
        or
        caused to be conceived, developed or reduced to practice prior to the course
        of
        your involvement, in any capacity, with Aspreva,, that you consider to be
        your
        property or the property of third parties and that you wish to have excluded
        from the scope of this Agreement (collectively referred to as “Previous
        Inventions”).
        If disclosure of any such Previous Invention would cause you to violate any
        prior confidentiality agreement, you understand that you are not to list
        such
        Previous Inventions in Exhibit A
        but are only to disclose a cursory name for each such invention, a listing
        of
        the party(ies) to whom it belongs and the fact that full disclosure as to
        such
        inventions has not been made for that reason. A space is provided on
Exhibit
        A
        for such purpose. If no such disclosure is attached, you represent that there
        are no Previous Inventions. If, in the course of your employment with Aspreva,
        you incorporate a Previous Invention into a product, process or machine of
        Aspreva, Aspreva is hereby granted and shall have a nonexclusive, royalty-free,
        irrevocable, perpetual, worldwide license (with rights to sublicense through
        multiple tiers of sublicensees) to make, have made, modify, use and sell
        such
        Previous Invention. Notwithstanding the foregoing, you agree that you will
        not
        incorporate, or permit to be incorporated, Previous Inventions in any Work
        Product without Aspreva's prior written consent.

       

      3.3                 Assignment
        of Rights.
        You will assign, and do hereby assign, to Aspreva or, at the option of Aspreva
        and upon notice from Aspreva, to Aspreva’s designee, your entire right, title
        and interest in and to all of your Work Product during your involvement,
        in any
        capacity, with Aspreva and all other rights and interests of a proprietary
        nature in and associated with your Work Product, including all patents, patent
        applications filed and other registrations granted thereon. To the extent
        that
        you retain or acquire legal title to any such rights and interests, you hereby
        declare and confirm that such legal title is and will be held by you only
        as
        trustee and 

       

      
        
          
          

        

        
          - 6
            -

          
            

          

        

        
          
          

        

      

       

      agent
        for Aspreva. You agree that Aspreva’s rights hereunder shall attach to all of
        your Work Product, notwithstanding that it may be perfected or reduced to
        specific form after you have terminated your relationship with Aspreva. You
        further agree that Aspreva’s rights hereunder are worldwide rights and are not
        limited to the United States or Canada, but shall extend to every country
        of the
        world.

       

      3.4                 Moral
        Rights.
        Without limiting the foregoing, you irrevocably waive any and all Moral Rights
        that you may have with respect to your Work Product, and agree never to assert
        any Moral Rights which you may have in your Work Product, including, without
        limitation, the right to the integrity of such Work Product, the right to
        be
        associated with the Work Product, the right to restrain or claim damages
        for any
        distortion, mutilation or other modification or enhancement of the Work Product
        and the right to restrain the use or reproduction of the Work Product in
        any
        context and in connection with any product, service, cause or institution,
        and
        you further confirm that Aspreva may use or alter any such Work Product as
        Aspreva sees fits in its absolute discretion. “Moral Rights” shall mean any
        right to claim authorship of an Invention, to object to or prevent the
        modification of any Invention, or to withdraw from circulation or control
        the
        publication or distribution of any Invention, and any similar right, existing
        under the judicial or statutory law of any country in the world, or under
        any
        treaty, regardless of whether or not such right is denominated or generally
        referred to as a “moral right.”

       

      3.5                 Goodwill.
        You hereby agree that all goodwill you have established or may establish
        with
        clients, customers, suppliers, principals, shareholders, investors,
        collaborators, strategic partners, licensees, contacts or prospects of Aspreva
        relating to the business or affairs of Aspreva (or of its parents, subsidiaries
        or affiliates), both before and after the Effective Date, shall, as between
        you
        and Aspreva, be and remain the property of Aspreva exclusively, for Aspreva
        to
        use, alter, vary, adapt and exploit as Aspreva shall determine in its
        discretion.

       

      3.6                 Assistance.
        You hereby agree to reasonably assist Aspreva, at Aspreva’s request,
        in:

       

      
        	 	
                (a)

              	
                making
                  patent applications for your Work Product, including instructions
                  to
                  lawyers and/or patent agents as to the characteristics of your
                  Work
                  Product in sufficient detail to enable the preparation of a suitable
                  patent specification, to execute all formal documentation incidental
                  to an
                  application for letters patent and to execute assignment documents
                  in
                  favour of Aspreva for such
                  applications;

              

      

       

      
        	 	
                (b)

              	
                making
                  applications for all other forms of intellectual property registration
                  relating to your Work Product;

              

      

       

      
        	 	
                (c)

              	
                prosecuting
                  and maintaining the patent applications and other intellectual
                  property
                  relating to your Work Product; and

              

      

       

      
        	 	
                (d)

              	
                registering,
                  maintaining and enforcing the patents and other intellectual property
                  registrations relating to your Work
                  Product.

              

      

      

       

      Your
        obligation to assist the Aspreva shall continue beyond the termination of
        your
        employment, but Aspreva shall compensate you at a reasonable rate after your
        termination for the time 

       

      
        
          
          

        

        
          - 7
            -

          
            

          

        

        
          
          

        

      

       

      actually
        spent by you on such assistance. In the event Aspreva is unable for any reason,
        after reasonable effort, to secure your signature on any document needed
        in
        connection with the actions specified in this section 3, you hereby irrevocably
        designate and appoint Aspreva and its duly authorized officers and agents
        as
        your agent and attorney in fact, which appointment is coupled with an interest,
        to act for and in your behalf to execute, verify and file any such documents
        and
        to do all other lawfully permitted acts to further the purposes of the preceding
        paragraph with the same legal force and effect as if executed by you. You
        hereby
        waive and quitclaim to Aspreva any and all claims, of any nature whatsoever,
        which you now or may hereafter have for infringement of any Work Product
        an
        intellectual property relating to Work Product assigned hereunder to
        Aspreva.

       

       

      3.7                 Assistance
        with Proceedings.
        You further agree to reasonably assist Aspreva, at Aspreva’s request and
        expense, in connection with any defence to an allegation of infringement
        of
        another person’s intellectual property rights, claim of invalidity of another
        person’s intellectual property rights, opposition to, or intervention regarding,
        an application for letters patent, copyright or trademark or other proceedings
        relating to intellectual property or applications for registration
        thereof.

       

      
        	
                4.

              	
                NON-COMPETE
                  PROVISION 

              

      

       

      4.1                 You
        agree that you will not, either alone or in partnership or in conjunction
        with
        any person, firm, company, corporation, syndicate, association or any other
        entity or group, whether as principal, agent, employee, director, officer,
        shareholder, consultant or in any capacity or manner whatsoever, whether
        directly or indirectly, for the period of 6 months after the date your
        employment ends for any reason, including but not limited to voluntary
        termination by you or involuntary termination by Aspreva, solicit,
        provide, or attempt to provide Conflicting Services anywhere in the USA,
        or for
        companies within pharmaceutical or related industry, in direct competition
        against Aspreva in those specific disease areas where Aspreva Pharmaceuticals,
        Inc was commercially operating or planning to operate, nor will you assist
        another person to solicit, attempt to provide, or provide Conflicting Services
        anywhere in the USA, or for companies within pharmaceutical or related industry,
        in direct competition against Aspreva in those specific disease areas where
        Aspreva Pharmaceuticals, Inc was commercially operating or planning to
        operate.

       

      4.2                 The
        parties agree that for purposes of this Agreement, “Conflicting
        Services”
        means engaging in any business activity, including but not limited to rendering
        services or providing any advice or assistance to or on behalf of any person
        or
        organization other than Aspreva, which relates to any product, service, process
        or the like, which directly competes with a product, service, process or
        the
        like with which you worked directly or indirectly during your employment
        by
        Aspreva or about which you acquired Confidential Information during your
        employment by Aspreva. 

       

      
        
          
          

        

        
          - 8
            -

          
            

          

        

        
          
          

        

      

      

       

      
        	
                5.

              	
                Non-Solicitation

              

      

       

      You
        agree that you will not, either alone or in partnership or in conjunction
        with
        any person, firm, company, corporation, syndicate, association or any other
        entity or group, whether as principal, agent, employee, director, officer,
        shareholder, consultant or in any capacity or manner whatsoever, whether
        directly or indirectly, for the term of employment and continuing for a period
        of 6 months after the date your employment ends for any reason, including
        but
        not limited to voluntary termination by
        you or involuntary termination by Aspreva, other than on behalf of
        Aspreva:

       

      5.1                 solicit,
        induce, encourage, or participate in soliciting, inducing, or encouraging
        any
        employee, independent contractor or consultant of Aspreva to terminate his
        or
        her relationship with Aspreva or to work in any capacity for any person or
        entity other than Aspreva;

       

      5.2                 hire,
        employ, or engage in business with or attempt to hire, employ, or engage
        in
        business with any person employed by Aspreva or who has left the employment
        of
        Aspreva within the preceding three (3) months or discuss any potential
        employment or business association with such person, even if you did not
        initiate the discussion or seek out the contact;

       

      5.3                 solicit,
        induce or attempt to induce any Customer, supplier, principal, shareholder,
        investor, collaborator, strategic partner, licensee with whom you had direct
        or
        indirect contact or whose identity you learned as a result of your employment
        with Aspreva to terminate, diminish, or materially alter in a manner harmful
        to
        Aspreva its relationship with Aspreva; or

       

      5.4                 solicit,
        perform or attempt to perform any Conflicting Services for a Customer or
        for any
        consultant or contractor of Aspreva with whom you had direct or indirect
        contact
        or whose identity you learned as a result of your employment with Aspreva
        .

      

       

      The
        parties agree that for purposes of this Agreement, a “Customer”
        is any person or entity who or which, at any time during the two (2) years
        prior
        to the date your employment with Aspreva ends, (i) contracted for, was billed
        for, or received from Aspreva any product, service or process with which
        you
        worked directly or indirectly during your employment by Aspreva or about
        which
        you acquired Confidential Information; or (ii) was in contact with you or
        in
        contact with any other employee, owner, or agent of Aspreva, of which contact
        you were or should have been aware, concerning any product, service or process
        with which you worked directly or indirectly during your employment with
        Aspreva
        or about which you acquired Confidential Information; or (iii) was solicited
        by
        Aspreva or in consideration or planning to be solicited by Aspreva in an
        effort
        in which you were involved or of which you were or should have been aware.
        

       

       

      
        	
                6.

              	
                DUTY
                  OF LOYALTY.

              

      

       

      6.1                 While
        you are an employee of Aspreva, you will not provide services to or enter
        into a
        contract of employment or service in any capacity for any business which
        is in
        any way competitive with Aspreva’s business without the prior written consent of
        Aspreva.

       

      
        
          
          

        

        
          - 9
            -

          
            

          

        

        
          
          

        

      

      
      

       

      
        	
                7.

              	
                Provisions
                  Reasonable. 

              

      

       

      It
        is acknowledged and agreed that:

       

      	 	
              both
                before and since the Effective Date Aspreva has operated and competed
                and
                will operate and compete in a global market, with respect to the
                Aspreva
                Business;

            

       

      	 	
              competitors
                of Aspreva are located in countries around the
                world;

            

       

      	  	
              in
                order to protect Aspreva adequately, any enjoinder of competition
                would
                have to apply world wide; [comment - may need to adjust depending
                upon the
                restriction decided upon in the non-compete
                provision]

            

       

      	 	
              during
                the course of your employment by Aspreva, both before and after the
                Effective Date, on behalf of Aspreva, you have acquired and will
                acquire
                knowledge of, and you have come into contact with, initiated and
                established relationships with and will come into contact with, initiate
                and establish relationships with, both existing and new clients,
                customers, suppliers, principals, contacts and prospects of Aspreva,
                and
                that in some circumstances you have been or may well become the senior
                or
                sole representative of Aspreva dealing with such persons;
                

            

       

      	  	
              You
                agree that you have read this entire Agreement and understand it.
                You
                agree that this Agreement does not prevent you from earning a living
                or
                pursuing your career. You agree that the restrictions contained in
                this
                Agreement are reasonable, proper, and necessitated by Aspreva’s legitimate
                business interests. You represent and agree that you am entering
                into this
                Agreement freely and with knowledge of its contents with the intent
                to be
                bound by the Agreement and the restrictions contained in
                it;

            

       

      	 	
              in
                light of the foregoing, the provisions of this Agreement are reasonable
                and necessary for the proper protection of the business, property
                and
                goodwill of Aspreva; 

            

       

      	 	
              In
                the event that a court finds this Agreement, or any of its restrictions,
                to be ambiguous, unenforceable, or invalid, you and Aspreva agree
                that the
                court shall read the Agreement as a whole and interpret the restriction(s)
                at issue to be enforceable and valid to the maximum extent allowed
                by law;
                

            

       

      	  	
              If
                the court declines to enforce this Agreement in the manner provided
                in
                subsection 7(g), you and Aspreva agree that this Agreement will be
                automatically modified to provide Aspreva with the maximum protection
                of
                its business interests allowed by law and you agree to be bound by
                this
                Agreement as modified.

            

       

      
        	
                8.

              	
                Legal
                  and Equitable Remedies. 

              

      

       

      8.1                 You
        agree that it may be impossible to assess the damages caused by your violation
        of this Agreement or any of its terms. You agree that any threatened or actual
        violation of this Agreement or any of its terms will constitute immediate
        and
        irreparable injury to Aspreva and Aspreva shall have the right to enforce
        this
        Agreement and any of its provisions by 

       

      
        
          
          

        

        
          - 10
            -

          
            

          

        

        
          
          

        

      

       

      injunction,
        specific performance or other equitable relief, without bond and without
        prejudice to any other rights and remedies that Aspreva may have for a breach
        or
        threatened breach of this Agreement. 

       

      8.2                 You
        agree that if Aspreva is successful in whole or in part in any legal or
        equitable action against you under this Agreement, Aspreva shall be entitled
        to
        payment of all costs, including reasonable attorney’s fees, from
        you.

       

      8.3                 In
        the event Aspreva enforces this Agreement through a court order, you agree
        that
        the restrictions of Sections 4 and 5 shall remain in effect for a period
        of six
        (6) months from the effective date of the Order enforcing the
        Agreement.

       

      
        	
                9.

              	
                NOTIFICATION
                  OF NEW EMPLOYER.

              

      

       

      9.1                 In
        the event that you leave the employ of Aspreva, you hereby consent to the
        notification of your new employer of your rights and obligations under this
        Agreement.

       

      
        	
                10.

              	
                RETURN
                  OF COMPANY PROPERTY.

              

      

       

      10.1                When
        you leave the employ of Aspreva, you will deliver to Aspreva any and all
        drawings, notes, memoranda, specifications, devices, formulas, and documents,
        together with all copies thereof, and any other material containing or
        disclosing any Work Product or Confidential Information. You further agree
        that
        any property situated on Aspreva's premises and owned by Aspreva, including
        disks and other storage media, filing cabinets or other work areas, is subject
        to inspection by company personnel at any time with or without notice.

       

      
        	
                11.

              	
                GENERAL

              

      

       

      11.1                Continuing
        Obligations.
        The provisions of this Agreement shall survive the termination of my employment,
        regardless of the reason, and the assignment of this Agreement by Aspreva
        to any
        successor in interest or other assignee.

       

      11.2                    
        Binding
        Nature of Agreement.
        This Agreement is not assignable by you. You agree that this Agreement shall
        be
        binding upon your heirs and estate. This Agreement is intended to inure to
        the
        benefit of and be enforceable by Aspreva, and its successors and assigns.
        

       

      11.3                 No
        Conflicting Obligations.
        You represent and warrant that you will not use or disclose to other persons
        at
        Aspreva information that (i) constitutes a trade secret of persons other
        than
        Aspreva during your employment at Aspreva, or (ii) which is confidential
        information owned by another person. You represent and warrant that you have
        no
        agreements with or obligations to others with respect to the matters covered
        by
        this Agreement or concerning the Confidential Information that are in conflict
        with anything in this Agreement.

       

      11.4                 Publicity.
        You shall not, without the prior written consent of Aspreva, make or give
        any
        public announcements, press releases or statements to the public or the press
        regarding your Work Product or any Confidential Information.

       

      
        
          
          

        

        
          - 11
            -

          
            

          

        

        
          
          

        

      

       

      11.5                 Severability.
        If any covenant or provision of this Agreement or of a section of this Agreement
        is determined by a court of competent jurisdiction to be void or unenforceable
        in whole or in part, then such void or unenforceable covenant or provision
        shall
        not affect or impair the enforceability or validity of the balance of the
        section or any other covenant or provision. If moreover, any one or more
        of the
        provisions contained in this Agreement shall for any reason be held to be
        excessively broad as to duration, geographical scope, activity or subject,
        it
        shall be construed by limiting and reducing it, so as to be enforceable to
        the
        extent compatible with the applicable law as it shall then appear.

       

      11.6                 Time
        of Essence/No Waiver.
        Time is of the essence hereof and no waiver, delay, indulgence, or failure
        to
        act by Aspreva regarding any particular default or omission by you shall
        affect
        or impair any of Aspreva’s rights or remedies regarding that or any subsequent
        default or omission that is not expressly waived in writing, and in all events
        time shall continue to be of the essence without the necessity of specific
        reinstatement.

       

      11.7                 Further
        Assurances.
        The parties will execute and deliver to each other such further instruments
        and
        assurances and do such further acts as may be required to give effect to
        this
        Agreement.

       

      11.8                 Notices.
        All notices and other communications that are required or permitted by this
        Agreement must be in writing and shall be hand delivered or sent by express
        delivery service or certified or registered mail, postage prepaid, or by
        facsimile transmission (with written confirmation copy by registered first-class
        mail) to the parties at the addresses indicated below.

       

      If
        to the Corporation: Aspreva
        Pharmaceuticals Inc

      C/o
        Aspreva Pharmaceuticals Corporation

      1203-4464
        Markham Rd, Victoria, BC, Canada. V8Z 7X8 

      or
        Aspreva Pharmaceuticals Corporation Corporate Headquarters address at the
        time
        notice is given 

      

      

      Attn:
        If to Charles
        F. Goulburn:

      Charles
        F. Goulburn 

      346
        Mount Prospect Road

      Far
        Hills, New Jersey, 07931

      or
        home address as shown in the Corporation’s records at the time notice is
        given

       

      Any
        notice delivered shall be deemed to have been given and received on the date
        of
        delivery. Any notice mailed shall be deemed to have been given and received
        on
        the fifth business day following the date it was posted. 

       

      11.9                Amendment.
        No amendment, modification, supplement or other purported alteration of this
        Agreement shall be binding unless it is in writing and signed by you and
        by
        Aspreva.

       

      11.10               Entire
        Agreement.
        This Agreement supersedes all previous dealings, understandings, and
        expectations of the parties and constitutes the whole agreement with respect
        

       

      
        
          
          

        

        
          - 12
            -

          
            

          

        

        
          
          

        

      

       

                                  to
        the matters
        contemplated hereby, and there are no representations, warranties, conditions
        or
        collateral agreements between the parties with respect to such transactions
        except as expressly set out herein.

       

      11.11               Governing
        Law.
        This Agreement will be governed by and construed according to the laws of
        the
        State of New Jersey as such laws are applied to agreements entered into and
        to
        be performed entirely within New Jersey between New Jersey residents. I hereby
        expressly consent to the personal jurisdiction of the state and federal courts
        located in New Jersey for any lawsuit filed there against me by Company arising
        from or related to this Agreement.

       

      11.12               Independent
        Legal Advice.
        You hereby acknowledge that you have obtained or have had an opportunity
        to
        obtain independent legal advice in connection with this Agreement, and further
        acknowledge that you have read, understand, and agree to be bound by all
        of the
        terms and conditions contained herein.

       

      11.13               Acceptance.
        If
        the foregoing terms and conditions are acceptable to you, please indicate
        your
        acceptance of and agreement to the terms and conditions of this Agreement
        by
        signing below on this letter and on the enclosed copy of this letter in the
        space provided and by returning the enclosed copy so executed to us. Your
        execution and delivery to Aspreva of the enclosed copy of this letter will
        create a binding agreement between us.

       

      Thank
        you for your cooperation in this matter.

       

      Yours
        truly,

       

      ASPREVA
        PHARMACEUTICALS INC

       

      
        	 

                By: 

              	 
	 	/s/
                Noel Hall
	
              	
                Noel
                  Hall

              

      

       

      Accepted
        and agreed as of the 23rd
        day of September, 2004

       

      

      
        	 	 	/s/
                Charles F. Goulburn
	
                Witness
                  Signature

              	 	
                Signature
                  of Charles Goulburn 

              
	 	 	 
	 	 	 
	
                Witness
                  Name

              	 	 
	 	 	 
	 	 	 
	
                Occupation

              	 	 
	 	 	 
	 	 	 
	
                Address

              	 	 

      

       

      
        
          
          

        

        
          - 13
            -

          
            

          

        

        
          
          

        

      

       

      EXHIBIT
        A

      Exclusion
        from Work Product

       

       

      
        	TO:	Aspreva Pharmaceuticals,
                Inc.
	 	 
	
                FROM:  

              	 
	 	 
	
                DATE:  

              	 

      

       

      SUBJECT: Previous
        Inventions 

       

      1.             Except
        as listed in Section 2 below, the following is a complete list of all inventions
        or improvements relevant to the subject matter of my employment by Aspreva
        Pharmaceuticals, Inc.
        (the “Company”)
        that have been made or conceived or first reduced to practice by me alone
        or
        jointly with others prior to my engagement by the Company:

       

      

      
        	 o	
                No
                  inventions or improvements.

              
	 	 
	 o	
                See
                  below:

              
	 	 
	 	 
	 	 

      

       

      
        	 o	
                Additional
                  sheets attached.

              

      

       

       

      2.             Due
        to a prior confidentiality agreement, I cannot complete the disclosure under
        Section 1 above with respect to inventions or improvements generally listed
        below, the proprietary rights and duty of confidentiality with respect to
        which
        I owe to the following party(ies):

       

      
        	 	
                 Invention
                  or
                  Improvement 

              	 	
                 Party(ies) 

              	 	
                 Relationship

              
	1.  	 	 	 	 	 
	2.    	 	 	 	 	 
	3.  	 	 	 	 	 
	 	 	 	 	 	 
	o	
                AAdditional
                  sheets attached.

              	 	 	 	 

      

      

      
        
          
          

        

        
          - 14
            -Change of Control Agreement

    Exhibit
      10.31

     

    
 

    SCHEDULE
      B

     

    ASPREVA
      PHARMACEUTICALS CORPORATION

     

     

    October
      24, 2006

     

    Charles
      F. Goulburn

    346
      Mount Prospect Road

    Far
      Hills, NJ 07931

     

    Dear
      Mr. Goulburn:

     

    Re:
      Change in Control Agreement

     

               
      Aspreva Pharmaceuticals Corporation (the “Corporation”) considers it essential
      to the best interests of its members to foster the continuous employment of
      its
      senior executive officers.  In this regard, the Board of Directors of the
      Corporation (the “Board”) has determined that it is in the best interests of the
      Corporation and its members that appropriate steps should be taken to reinforce
      and encourage management’s continued attention, dedication and availability to
      the Corporation in the event of a Potential Change in Control (as defined in
      Section 2), without being distracted by the uncertainties which can arise from
      any possible changes in control of the Corporation.

     

               
      In order to induce you to agree to remain in the employ of the Corporation,
      such
      agreement evidenced by the employment agreement entered into as of the date
      of
      this Agreement between you and the Corporation (the “Employment Agreement”) and
      in consideration of your agreement as set forth in Section 3 below, the
      Corporation agrees that you shall receive and you agree to accept the severance
      and other benefits set forth in this Agreement should your employment with
      the
      Corporation be terminated subsequent to a Change of Control (as defined in
      Section 2) in full satisfaction of any and all claims that now exist or then
      may
      exist for remuneration, fees, salary, bonuses or severance arising out of or
      in
      connection with employment by the Corporation or the termination of your
      employment:

     

    1.                 
      Terms
      of Agreement.

     

               
      This
      Agreement shall be in effect for a term commencing on the Effective Date of
      the
      Employment Agreement (as therein defined) and ending on the date of termination
      of the Employment Agreement.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    2.                 
      Definitions.

     

               
      (a)        “Affiliate” means a corporation
      that is an affiliate of the Corporation

                           
      under the Securities
      Act
      (British Columbia), as amended from time to time.

     

    (b)              
      “Change in Control” of the Corporation shall be deemed to have
      occurred:

     

    (i)             if
      a merger, amalgamation, arrangement, consolidation,
      reorganization or transfer takes place in which Equity Securities
      of the
      Corporation possessing more than 50% of the total combined voting
      power of the Corporation’s outstanding Equity Securities are
      acquired by a person or persons different from the persons holding those Equity
      Securities immediately prior to such transaction, and the composition of the
      Board following such transaction is such that the directors of the Corporation
      prior to the transaction constitute less than 50% of the Board membership
      following the transaction, except that no Change in Control will be deemed
      to
      occur if such merger, amalgamation, arrangement, consolidation, reorganization
      or transfer is with any subsidiary or subsidiaries of the
      Corporation;

     

    (ii)            if
      any person, or any combination of persons acting jointly or in

    concert
      by virtues of an agreement, arrangement, commitment or understanding shall
      acquire of hold, directly or indirectly, 50% or more of the voting rights
      attached to all outstanding Equity Securities; or

     

    (iii)           if
      any person, or any combination of persons acting jointly or in concert by virtue
      of an agreement, arrangement, commitment or understanding shall acquire or
      hold,
      directly or indirectly, the right to appoint a majority of the directors of
      the
      Corporation; or

     

    (iv)          if
      the Corporation sells, transfers or otherwise disposes of all or substantially
      all of its assets, except that no Change of Control will be deemed to occur
      if
      such sale or disposition is made to a subsidiary or subsidiaries of the
      Corporation.

     

    Provided
      however, that a Change in Control shall not be deemed to have occurred if such
      Change in Control results solely from the issuance, in connection with a bona
      fide financing or series of financings by the Corporation of Equity
      Securities.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    (c)               
      “Base Salary” shall mean the annual base salary, as referred to in Section 3
      (Base Salary), and as adjusted from time to time in accordance with Section
      4
      (Annual Review), of the Employment Agreement.

     

    (d)               
      “Bonus” shall mean the bonus referred to in Section 5 (Performance Bonus) of the
      Employment Agreement.

     

    (e)               
      “Cause” shall have the meaning set out in Section 16 (Termination by the
      Corporation for Cause) of the Employment Agreement.

     

    (f)                
      “Date of Termination” shall mean, if your employment is terminated, the date
      specified in the Notice of Termination.

     

    (g)               
      “Equity Security” in respect of a security of the Corporation, shall have the
      meaning ascribed thereto in Part II of the Securities
      Act (British
      Columbia), as it existed on the date of this Agreement, and also means any
      security carrying the right to convert such security into, exchange such
      security for , or entitling the holder to subscribe for, any equity security,
      or
      into or for any such convertible or exchangeable security or security carrying
      a
      subscription right.

     

    (h)               
      “Good Reason” shall mean the occurrence of one or more of the following events,
      without your express written consent, within 12 months of Change in
      Control:

     

    (i)             a
      material change in your status, position, authority or responsibilities that
      does not represent a promotion from or represent an adverse change from your
      status, position, authority or responsibilities in effect immediately prior
      to
      the Change in Control;

     

     (ii)            a
      material reduction by the corporation, in the aggregate, in your
      Base Salary, or incentive, retirement, health benefits, bonus or other
      compensation plans provided to you immediately prior to the Change in Control,
      unless an equitable arrangement has been made with respect to such benefits
      in
      connection with a Change in Control;

     

     (iii)           a
      failure by the Corporation to continue in effect any other compensation
      plan in which you participated immediately prior to the Change in control
      (except for reasons of non-insurability), including but not limited to,
      incentive, retirement and health benefits, unless an equitable arrangement
      has
      been made with respect to such benefits in connection with a Change in
      Control;

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    (iv)          any
      request by the Corporation or any affiliate of the Corporation that you
      participate in an unlawful act; or

     

    (v)           any
      purported termination of your employment by the Corporation after a Change
      in
      Control which is not effected pursuant to a Notice of Termination satisfying
      the
      requirements of clause (i) below and for the purposes of this Agreement, no such
      purported termination shall be effective.

     

    (i)                 
      ‘Notice of Termination” shall mean a notice, in writing, communicated to the
      other party in accordance with Section 6 below, which shall indicate the
      specific termination provision in this Agreement relied upon and shall set
      forth
      in reasonable detail the facts and circumstances claimed to provide a basis
      for
      termination of your employment under the provision so indicated.

     

    (j)                
      “Potential Change in Control” of the Corporation shall be deemed to have
      occurred if:

     

    (i)          
      the Corporation enters into an agreement, the consummation of which would result
      in the occurrence of a Change in Control;

     

                                       
      (ii)          any person (including
      the Corporation) publicly announces an
      intention to take or to consider taking actions which if consummated would
      constitute a Change in Control; or

     

                                      
      (iii)         the Board adopts a
      resolution to the effect that, for the purposes of
      this Agreement, a Potential Change in Control of the Corporation has
      occurred.

     

    3.         Potential
      Change in Control.

     

               
      You
      agree that, in the event of a Potential Change in control of the Corporation
      occurring after the Effective Date, and until 12 months after a Change in
      Control, subject to your right to terminate your employment by issuing and
      delivering a Notice of Termination for Good Reason, you will continue to
      diligently carry out your duties and obligations, on the terms set out in the
      Employment Agreement.

     

     

    4.        
      Compensation
      Upon Termination Following Change in Control.

     

               
      Subject
      to compliance by you with Section 3, upon your employment terminating pursuant
      to a Notice of Termination within 12 months after a Change in Control, the
      Corporation agrees that you shall receive and you agree to accept, subject
      to
      your prior resignation as a director of the Corporation, the following payments
      in full satisfaction of 

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    any
      and all claims you may have or then may have against the Corporation, for
      remuneration, fees, salary, benefits, bonuses or severance, arising out of
      or in
      connection with your employment by the Corporation or the termination of your
      employment:

     

    (a)               
      If your employment shall be terminated by the Corporation of Cause or by
you
      other than for Good Reason, the terms of the Employment Agreement shall govern
      and the Corporation shall have no further obligations to you under this
      Agreement.

     

     

     

    (b)               If
      your employment by the
      Corporation shall be terminated by you for Good
      Reason or by the Corporation other than for Cause, then you shall be entitled
      to
      the payments and benefits provided below:

     

    (i)            subject
      to the withholding of all applicable statutory deductions, the Corporation
      shall
      pay you a lump sum equal to 12 months’ Base Salary, as referred to in Section 3
      (Base Salary) and as adjusted from time to time in accordance with Section
      4
      (Annual Review) of the Employment Agreement, plus other sums owed for arrears
      of
      salary, vacation pay and, if awarded, Bonus;

     

                           
      (ii)           to the extent permitted
      by
      law and subject to the terms and
      conditions of any benefit plans in effect from time to time, the Corporation
      shall maintain the benefits and payments set out in Section 6 (Benefits) of
      the
      Employment Agreement during the 12 month period;

     

                           
      (iii)           the Corporation shall
      arrange for you to be provided with such outplacement
      career counseling services as are reasonable and appropriate, to assist you
      in
      seeking new executive level employment; and

     

    (iv)           all
      incentive stock options granted to you by the Corporation under any
      stock option agreement that is entered into between you and the Corporation
      and
      is outstanding at the time of termination of your employment, which incentive
      stock options have not yet vested, shall immediately vest upon the termination
      of your employment and shall be fully exercisable by you in accordance with
      the
      terms of the agreement or agreements under which such options were
      granted.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    You
      shall not be required to mitigate the amount of any payment provided for in
      this
      Section 4 by seeking other employment or otherwise, nor will any sums actually
      received be deducted.

     

    5.
              Binding
      Agreement

     

              
      This Agreement shall ensure to the benefit of and be enforceable by your
      personal or legal representatives, executors, administrators, successors, heirs,
      distributes, devisees and legatees.  If you dies while any amount would
      still be payable to you under this Agreement if you had continued to live,
      that
      amount shall be paid in accordance with the terms of this Agreement to your
      devisee, legatee or other designee or, if there is no such designee, to your
      estate.

     

    6.                 
      Notices.

     

               
      Any notice or other communication required or contemplated under, this Agreement
      to be given by one party to the other shall be delivered or mailed by prepaid
      registered post to the party to receive same at the addresses set out
      below:

     

               
       If
      to Aspreva Pharmaceuticals Corporation:

     

               
      Aspreva Pharmaceuticals Corporation

               
      c/o Farris, Vaughan, Wills & Murphy

               
      26th
      Floor, 700 West Georgia Street

               
      Vancouver, BC V7Y 1B3

     

               
      Attn: R. Hector MacKay-Dunn

     

               
      If
      to Noel Hall:

     

               
      Noel Hall

               
      5077 Cordova Bay Road

               
      Victoria, BC V8Y 2K1

     

     

     

    Any
      notice delivered shall be deemed to have been given and received on the first
      business day following the date of delivery.  Any notice mailed shall be
      deemed to have been given and received on the fifth business day following
      the
      date it was posted, unless between the time of mailing and actual receipt of
      the
      notice there shall be a mail strike, slow-down or other labour dispute which
      might affect delivery of the notice by mail.  In such event, the notice
      shall be effective only if actually delivered.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    7.                 
      Modification:
      Amendments:  Entire Agreement

     

    This
      Agreement may not be modified, waived or discharged unless such waiver,
      modification or discharge is agreed to in writing and signed by you and such
      officer as may be specifically designated by the Board.  No waiver by
      either party at any time of any breach by the other party of, or compliance
      with, any condition or provision of this Agreement to be performed by such
      other
      party will be deemed a waiver of similar or dissimilar provisions or conditions
      at the same or at any prior or subsequent time.  Except as set forth in
      your Employment Agreement, no agreements or representations, oral or otherwise,
      express or implied, with respect to the subject matter hereof have been made
      by
      either party which are not expressly set forth in this Agreement.

     

    8.                 
      Governing
      Law

     

    This
      Agreement shall be governed by and interpreted in accordance with the laws
      of
      the Province of British Columbia and applicable laws of Canada and the parties
      hereto attorn to the exclusive jurisdiction of the provincial and federal courts
      of such province.

     

    9.                 
      Validity

     

    The
      invalidity or unenforceability of any provision of this Agreement shall not
      affect the validity or enforceability of any other provision of this Agreement,
      which shall remain in full force and effect.

     

    10.             
      No
      Employment or Service Contract

     

    Nothing
      in this Agreement shall confer upon you any right to continue in the employment
      of the Corporation for any period of specific duration or interfere with or
      otherwise restrict in any way the rights of the Corporation or you, which rights
      are hereby expressly reserved by each, to terminate your employment at any
      time
      for any reason whatsoever, with or without cause.

     

    If
      the foregoing sets forth our agreement on this matter, kindly sign and return
      to
      the Corporation a copy of this letter.

     

    
      
        	 	Yours truly,
	 	ASPREVA PHARMACUETICALS
                CORPORATION
	 	 	 
	 	 By:
                	 /s/
                Richard M. Glickman
	 	 	Authorized Signatory
	 	 	 

      

    

      Accepted
      and agreed to by Charles F. Goulburn, as of the 24th
      day of October 2006.

     

    
      
        
          	 /s/
                  Rick Goulburn	 
	 Rick
                  Goulburn	 
	 	 

        

      

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    

      

      

      

      

       

      October
        23rd,
        2006

      

      

      

       

      Rick
        Goulburn, 

      

      Dear
        Rick,

      

      

      I
        am pleased to present to you the following proposal for EVP
        Global Pharmaceutical Operations and an
        Officer of
        Aspreva Pharmaceuticals Corp. The position
        description attached as schedule A) with Aspreva Pharmaceuticals Corporation,
        (“the Company”). Please review the changes and if acceptable, execute and return
        the letter to my attention.

      

       

      

        
          	
                  Position:

                	
                  EVP
                    Global Pharmaceutical Operations
                    These duties and functions will be conducted in accordance with
                    and
                    adhering to all corporate policies and procedures. The Company
                    may change
                    your position, duties, and work location from time to time in
                    its
                    discretion, acting reasonably.

                
	
                  Department:

                	
                  Global
                    Pharma Operations

                
	
                  Location:

                	
                  Basking
                    Ridge, New Jersey, USA

                
	
                  Supervisor:
                    

                	
                  President
                    or subsequent designate

                
	
                  Start
                    Date:

                	
                  November
                    1st,
                    2006

                
	
                  Salary:

                	
                  $277,000
                    USD per annum

                
	
                  Bonus:

                	
                  Remains
                    unchanged

                
	
                  Benefits:
                    

                	
                  No
                    change

                
	
                  Vacation:

                	
                  No
                    change

                

        

      

       

      Change
        of Control: An amendment to your current “Change of Control” terms is also
        enclosed.

       

      If
        you have any questions or concerns please feel free to contact me. Please
        sign
        and return this letter, which will become an amendment to your employment
        agreement, the position description below and the change of control form
        attached.

      

      Sincerely,

       

      ASPREVA
        PHARMACEUTICALS CORPORATION

      

       

      

      N
        Hall 

      President

       

      Enclosure

      

      

      
        	/s/
                Rick Goulburn	 	
                October
                  24, 2006

              
	R
                Goulburn       	 	
                Date

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