Document:

Employee noncompetition, nondisclosure and developments, Colleen Wilson

 Exhibit 10.43 
 EMPLOYEE NONCOMPETITION, 
 NONDISCLOSURE AND DEVELOPMENTS AGREEMENT

 This Employee Noncompetition, Nondisclosure and Developments Agreement (the “Agreement”) is entered into by
and between Colleen Wilson (Print Name Here) the undersigned employee and Rib-X Pharmaceuticals, Inc., its parents, affiliates and subsidiaries (the “Company”). 

NOW THEREFORE, in consideration of my employment by the Company and of the covenants herein, my employment with the Company, and for
other good and valuable consideration, I hereby covenant and agree as follows: 
 1. Best Efforts. 

During the period of my employment by the Company, I shall devote my full time and best efforts to the business of the Company, and I
shall neither pursue any business opportunity outside the Company nor take any position with any organization other than the Company without the written approval of the Chief Executive Officer or her designee. 

2. Noncompetition. 

During the period of my employment by the Company, I shall not, directly or indirectly, alone or as a consultant, partner, officer,
director, employee, joint venturer, lender or stockholder of any entity, engage in any business or activity that is in competition with the products or services being created, developed, manufactured, marketed, distributed or sold by the Company in
(a) the State of Connecticut, (b) the States of New York, Massachusetts and Connecticut, (c) the continental United States of America, (d) the United States and Europe or (e) worldwide. For one year following the termination
of my employment, regardless of the reasons for my termination, I will refrain from management of or participation in research programs at or on behalf of any entity in areas related to antimicrobials or in areas related to specific chemical
approaches or series the Company is engaged in during my employment or in which the Company is planning to engage or has in the past engaged. In the case of areas of business unrelated to antimicrobials, for one year following the termination of my
employment, regardless of the reasons for my termination, I will refrain from management of or participating in any such non-antimicrobial programs which are under prosecution at the Company, in which the Company is planning to engage or has in the
past engaged in. 
 3. Nonsolicitation of Customers. 
 During the period of my employment by the Company and for one year following the termination of my employment, regardless of the reasons for my termination, I shall not directly or indirectly, alone or as
a consultant, partner, officer, director, employee, joint venturer, lender or stockholder of any entity, solicit or do business with any customer of the Company or any potential customer of the Company (i) with whom I have had contact or
(ii) about whom I obtained information, or became familiar with through Confidential Information (as defined in Paragraph 5), during the course of my employment with the Company. 

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 4. Nonsolicitation of Employees. 

(a) During the period of my employment by the Company and for one year following the termination of my employment, regardless of the
reasons for the termination, I will not, in any manner, hire or engage, or assist any company or business organization by which I am employed or which is directly or indirectly controlled by me to hire or engage, any person who is or was employed by
the Company (or is or was an agent, representative, contractor, project consultant or consultant of the Company) at the time of my termination. 
 (b) During the period of my employment by the Company and for one year following the termination of my employment, regardless of the reasons for the termination, I will not, in any manner, solicit,
recruit or induce, or assist any company or business organization by which I am employed or which is directly or indirectly controlled by me to solicit, recruit or induce, any person who is or was employed by the Company (or is or was an agent,
representative, contractor, project consultant or consultant of the Company) at the time of my termination, to leave his or her employment, relationship or engagement with the Company. 
 5. Nondisclosure. 
 I shall not at any time, whether during or after the
termination of my employment, reveal to any person or entity any Confidential Information except to employees of the Company who need to know such Confidential Information for the purposes of their employment, or as otherwise authorized by the
Company in writing. The term “Confidential Information” shall include any information concerning the organization, business or finances of the Company or of any third party which the Company is under an obligation to keep confidential that
is maintained by the Company as confidential. Such Confidential Information shall include, but is not limited to, trade secrets or confidential information respecting inventions, products, designs, methods, know-how, techniques, systems, processes,
specifications, blueprints, engineering data, software programs, works of authorship, customer lists, customer information, financial information, pricing information, personnel information, business plans, projects, plans and proposals. I shall
keep confidential all matters entrusted to me and shall not use or attempt to use any Confidential Information except as may be required in the ordinary course of performing my duties as an employee of the Company, nor shall I use any Confidential
Information in any manner which may injure or cause loss or may be calculated to injure or cause loss to the Company, whether directly or indirectly. 
 6. Assignment of Developments. 
 (a) If at any time or times during my
employment, I shall (either alone or with others) make, conceive, create, discover, invent or reduce to practice any Development that (i) relates to the business of the Company or any customer of or supplier to the Company or any of the
products or services being developed, manufactured or sold by the Company or which may be used in relation therewith; or (ii) results from tasks assigned to me by the Company; or (iii) results from the use of premises or personal property
(whether tangible or intangible) owned, leased or contracted for by the Company, then all such Developments and the benefits thereof are and shall immediately become the sole and absolute property of the Company and its assigns, as works made for
hire or otherwise. The term “Development” shall mean any invention, 

  

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modification, discovery, design, development, improvement, process, software program, work of authorship, documentation, formula, data, technique, know-how, trade secret or intellectual property
right whatsoever or any interest therein (whether or not patentable or registrable under copyright, trademark or similar statutes (including, but not limited to, the Semiconductor Chip Protection Act) or subject to analogous protection). I shall
promptly disclose to the Company (or any persons designated by it) each such Development. I hereby assign all rights (including, but not limited to, rights to inventions, patentable subject matter, copyrights and trademarks) I may have or may
acquire in the Developments and all benefits and/or rights resulting therefrom to the Company and its assigns without further compensation and shall communicate, without cost or delay, and without disclosing to others the same, all available
information relating thereto (with all necessary plans and models) to the Company. 
 (b) Excluded Developments. I
represent that the Developments identified in the Appendix, if any, attached hereto comprise all the Developments that I have made or conceived prior to my employment by the Company and that are owned or controlled by me, which Developments are
excluded from this Agreement. I understand that it is only necessary to list the title of such Developments and the purpose thereof but not details of the Development itself. If no Developments are identified in the Appendix, it will be deemed that
there are no such exclusions. 
 7. Further Assurances. 
 I shall, during my employment and at any time thereafter, at the request and cost of the Company, promptly sign, execute, make and do all such deeds, documents, acts and things as the Company and its duly
authorized officers may reasonably require: 
 (a) to apply for, obtain, register and vest in the name of the
Company alone (unless the Company otherwise directs) patents, copyrights, trademarks or other analogous protection in any country throughout the world relating to a Development and when so obtained or vested to renew and restore the same; and

 (b) to defend any judicial, opposition or other proceedings in respect of such applications and any judicial,
opposition or other proceeding, petition or application for revocation of any such patent, copyright, trademark or other analogous protection. 
 If the Company is unable, after reasonable effort, to secure my signature on any application for patent, copyright, trademark or other analogous protection or other documents regarding any legal
protection relating to a Development, whether because of my physical or mental incapacity or for any other reason whatsoever, I hereby irrevocably designate and appoint the Company and its duly authorized officers and agents as my agent and
attorney-in-fact, to act for and in my behalf and stead to execute and file any such application or applications or other documents and to do all other lawfully permitted acts to further the prosecution and issuance of patent, copyright or trademark
registrations or any other legal protection thereon with the same legal force and effect as if executed by me. 

  

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 8. Employment At Will. 
 I understand that this Agreement does not constitute an implied or written employment contract and that my employment with the Company is on an “at-will” basis. Accordingly, I understand that
either the Company or I may terminate my employment at any time, for any or no reason, with or without prior notice. 
 9. Severability.

 I hereby agree that each provision and the subparts of each provision herein shall be treated as separate and independent
clauses, and the unenforceability of any one clause shall in no way impair the enforceability of any of the other clauses of the Agreement. Moreover, if one or more of the provisions contained in this Agreement shall for any reason be held to be
excessively broad as to scope, activity, subject or otherwise so as to be unenforceable at law, such provision or provisions shall be construed by the appropriate judicial body by limiting or reducing it or them, so as to be enforceable to the
maximum extent compatible with the applicable law as it shall then appear. I hereby further agree that the language of all parts of this Agreement shall in all cases be construed as a whole according to its fair meaning and not strictly for or
against either of the parties. 
 10. Amendments; Waiver. 
 Any amendment to or modification of this Agreement, or any waiver of any provision hereof, shall be in writing and signed by the Company. Any waiver by the Company of a breach of any provision of this
Agreement shall not operate or be construed as a waiver of any subsequent breach of such provision or any other provision hereof. 
 11.
Survival. 
 This agreement shall be effective as of the date entered below. My obligations under this Agreement shall
survive the termination of my employment regardless of the manner of such termination and shall be binding upon my heirs, executors, administrators and legal representatives. 
 12. Assignment. 
 The Company shall have the right to assign this Agreement
to its successors and assigns, and all covenants and agreements hereunder shall inure to the benefit of and be enforceable by said successors or assigns. I may not assign this Agreement. 
 13. Representations. 
 (a) I represent that my employment with the Company
and my performance of all of the terms of this Agreement do not and will not breach any agreement to keep in confidence proprietary information acquired by me in confidence or in trust prior to my employment by the Company. I have not entered into,
and I shall not enter into, any agreement either written or oral in conflict herewith. I agree that in the course of my employment with the Company, if the Company requests that I undertake activities that will cause me to use Confidential
Information of my prior employer, I will inform the Company of that fact. 

  

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 (b) I agree that the restrictions set forth in paragraph 2 hereof are reasonable and
necessary to protect specific business interests of the Company. I agree that any breach of this Agreement by me will cause irreparable damage to the Company and that in the event of such breach the Company shall have, in addition to any and all
remedies of law, the right to an injunction, specific performance or other equitable relief to prevent the violation of my obligations hereunder. The Company may apply for such injunctive relief in any court of competent jurisdiction without the
necessity of posting any bond or other security. 
 14. Governing Law; Forum Selection Clause. 

This Agreement and any claims arising out of this Agreement (or any other claims arising out of the relationship between the parties)
shall be governed by and construed in accordance with the laws of the State of Connecticut and shall in all respects be interpreted, enforced and governed under the internal and domestic laws of such state, without giving effect to the principles of
conflicts of laws of such state. Any claims or legal actions by one party against the other shall be commenced and maintained in any state or federal court located in such state, and I hereby submit to the jurisdiction and venue of any such court.

 15. Entire Agreement. 
 This Agreement sets forth the complete, sole and entire agreement between the parties on the subject matter herein and supersedes any and all other agreements, negotiations, discussions, proposals, or
understandings, whether oral or written, previously entered into, discussed or considered by the parties. 

  

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 IN WITNESS WHEREOF, the undersigned has executed this Agreement as a sealed instrument as of the date
written below. 
  

			
	 /s/ Colleen Wilson

	Signature	 	
	
	 Colleen Wilson

	Name (Please Print)
		
	Address:	 	 109 Church St. #603

		
		 	 New Haven, CT 06510

			
		
	Date:	 	 2/1/11

 APPENDIX — TITLE/PURPOSE OF DEVELOPMENTS 

The following is a complete list of all Developments owned or controlled by me and the purpose of those Developments: 

 

					
	If There Are No Developments Check Here	  	 ü
	  	
			
	If There Are Developments Check Here And List Below	  	  
	  	

 Developments and purpose: 
  

			
	  
	  	
		
	  
	  	
		
	  
	  	
		
	  
	  	
		
	  
	  	
		
	  
	  	
		
	  
	  	

  

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 - 2 -Letter Agreement

 Exhibit 10.44 

 
 

 
 April 6, 2012 
 Matthew A. Wikler, MD 
 PO Box 5000, PMB 84 

Rancho Santa Fe, CA 92067 
 Dear
Dr. Wikler, 
 We are very pleased to offer you employment at Rib-X Pharmaceuticals (“Rib-X”). Your start date will be effective
on or around April 30, 2012. We are very enthusiastic about the prospect of your joining the Rib-X team, and are confident of a mutually beneficial relationship. 
 Position and Compensation 
 Your initial position will be Chief Development Officer of Rib-X
reporting to Mark Leuchtenberger, President and CEO. During the course of your employment with Rib-X, your position and duties are, of course, subject to change. As a Rib-X employee, we expect that you will perform any and all duties and
responsibilities normally associated with your position in a satisfactory manner and to the best of your abilities at all times. Your performance will be reviewed formally at the end of the calendar year, and on a periodic basis thereafter as long
as you remain employed by Rib-X. 
 Your initial base pay shall be $13,541.67, payable semi-monthly (annualized to $325,000), less state,
federal and other applicable withholdings and taxes. Based upon your yearly performance and the overall performance of Rib-X, you may also be eligible for an annual bonus with a target of 30% of your base salary or $97,500. Any bonus to be paid will
be determined by our Compensation Committee and based 50% on your individual performance and 50% on Rib-X’s performance. Any annual bonus earned in respect of any year will be paid no later than 90 days following the end of such year. You must
be employed by Rib-X on the date any bonus is paid in order to receive it. Rib-X will review your compensation periodically. Your compensation also is subject to change, as Rib-X considers necessary or appropriate. 

Signing Bonus 
 In addition, you will
receive a signing bonus in the amount of $60,000 less all applicable withholdings and taxes. This signing bonus will be paid to you in its entirety within the first 30 days of your employment. If you leave Rib-X for any reason other than Good Reason
(as such term is defined in your Severance Agreement) or Rib-X terminates you for cause (as such term is defined in your Severance Agreement) within one year from your start date, you will be required to repay Rib-X for the net amount (less
applicable withholdings, taxes and deductions) received by you in respect of this signing bonus within thirty (30) days of such event. 

 Benefits 
 Equity: Provided that you have commenced employment with Rib-X, you will be granted, subject to approval by the Compensation Committee of the Board of Directors (the “Committee”), on the
date of the effectiveness of Rib-X’s Initial Public Offering a stock option award for such number of shares of Rib-X common stock as determined by the Committee which number of shares shall represent 1% of the outstanding capital stock of
Rib-X, calculated on a fully diluted basis on such date of grant and assuming in such calculation that the shares of Rib-X common stock to be issued at the closing of the Initial Public Offering have been issued (the “Option”). The
exercise price of the Option shall be equal to the Initial Public Offering price of Rib-X’s common stock. Should no Initial Public Offering take place by June 30, 2012, Rib-X shall grant the Option to you in the third quarter of 2012
provided that you are then employed by Rib-X at an exercise price equal to the fair market value of Rib-X’s common stock on the grant date. The Option shall vest commencing on your start date as follows: 25% of the Option shall vest on the
first anniversary of your start date and the remaining 75% of the Option shall vest ratably at the rate of
1/36th per month on each monthly anniversary
commencing one year and one month after your start date such that the Option shall be vested in full on the fourth anniversary of your start date provided that you are employed by Rib-X on the applicable dates. The Option shall be subject to the
terms and conditions of Rib-X’s stock plan then in effect and standard form of Option Agreement. Additional stock options may also be offered from time to time depending upon certain events, including for example the successful completion of
annual corporate goals. 
 Severance: Rib-X shall also provide severance to you upon termination of your employment in certain
circumstances pursuant to the terms set forth in the enclosed Severance Agreement. 
 Vacation Time: You will be entitled to paid
vacation time consistent with the senior executive level vacation policy offered by Rib-X. 
 Other Benefits: Rib-X currently offers
various benefits, including group medical and dental insurance, time off, short term disability, long term disability, life insurance and other benefits. These benefits may be modified or changed from time to time at the discretion of Rib-X. The
present benefit structure and other important information about the benefits for which you may be eligible is described in other documents, which you will receive upon the commencement of your employment. Where a particular benefit is subject to a
formal plan (i.e., medical insurance or life insurance), eligibility to participate in and receive any particular benefit is governed solely by the applicable plan document. Should you have any questions regarding benefits, please see Human
Resources for a copy of the applicable plan document. 
 Return Travel / Relocation 

We understand that, at least initially, you will maintain your home in California while residing in the New Haven area. In support of that we will allow
you to work remotely from California for a week up to once per quarter provided it is not a week that Rib-X requires you, as a member of the senior management team, to be elsewhere representing Rib-X. 

 In view of your need to find housing, and transport items from your current residence to the New Haven area,
we agree to assist you with expenses associated with these activities, within the terms of the executive level relocation policy offered by Rib-X. It is understood that if you terminate your employment within one year of your start date for any
reason other than Good Reason, you will be required to repay Rib-X for your relocation expenses that have been reimbursed by Rib-X. Rib-X has developed a relationship with Mobility Services International (MSI) who will assist you with your
relocation to the New Haven area. 
 In the event that you decide to sell your home in California and move permanently to the New Haven area, we
agree to assist you with expenses associated with selling your home, purchasing a new home (but not the purchase price for such home), and moving. To that extent, you would be eligible for the executive level relocation policy offered by Rib-X.
However, the reimbursements associated with the executive level relocation policy will be modified to deduct any expenses, as described in the previous paragraph, which may have already been reimbursed to you. It is understood that if you terminate
your employment for any reason other than Good Reason within one year of your move to New Haven you will be required to repay Rib-X for your relocation expenses that have been reimbursed by Rib-X. Rib-X has developed a relationship with Mobility
Services International (MSI) who will assist you with your relocation to the New Haven area. 
 Nature of relationship 

As a Rib-X employee, you will be expected to devote substantially all of your business time to the performance of your duties at Rib-X throughout your
employment with us. Notwithstanding the foregoing, as long as it does not interfere with your employment with Rib-X, you may serve as an officer, director or trustee or otherwise participate in educational, welfare, social, religious and civic
organizations, and up to two (2) additional boards upon prior approval of the Chief Executive Officer, which approval will not be unreasonably heald. Rib-X acknowledges that you currently serve on the Board of Directors of the Clinical and
Laboratory Standards Institute and on the Leadership Council of Franklin & Marshall College, and that nothing hereunder shall prohibit you from continuing to serve in such organizations in such capacities. While this letter reflects our
commitment to employ you and we look forward to a mutually rewarding relationship, this letter does not constitute a contract (express or implied) for a specific length of employment, and either party may choose to terminate the employment
relationship upon written notice to the other at any time and for any reason. 
 Non-Competition, Non-Solicitation, Non-Disclosure and
Developments Agreement 
 As a condition of your employment and continued employment with Rib-X, you are required to sign and comply with the
terms and conditions of the enclosed Non-Competition, Non-Disclosure and Developments Agreement. Also, just as Rib-X regards the protection of its trade secrets, and other confidential information as a matter of great importance, we also respect
that you may have an obligation to your present and/or prior employers to safeguard the confidential information of those companies, and we expect you to honor them as well. To that end, you should not take any documents or other confidential
information from your employer if and when you depart. Further, we want to make it perfectly clear you should not bring with you to Rib-X, or use in the performance of your responsibilities for Rib-X any proprietary business or

 
technical information, materials or documents of a former employer. Finally, you must provide Rib-X with a copy of any agreements with a former employer or other party that could restrict your
professional activities in any way on behalf of Rib-X. 
 I-9 information 
 On your start date, you must complete an I-9 Form including presenting any of the accepted forms of identification specified on the I-9 Form. Your employment with Rib-X is conditioned on your eligibility
to work in the United States. 
 We are pleased to inform you that we have successfully completed our pre-employment background and reference
checks. 
 This letter, the enclosed Severance Agreement and the enclosed Employee Noncompetition, Nondisclosure and Developments Agreement
constitute our entire offer regarding the terms and conditions of your employment by Rib-X. These supersede any prior agreements, or other promises or statements (whether oral or written) regarding the offered terms of employment. The terms of your
employment shall be governed by and construed under the laws of the State of Connecticut, without giving effect to conflict of laws principles. 

You may accept this offer of employment and the terms and conditions hereof by signing the enclosed additional copy of this letter. Your signature on the
copy of this letter and your submission of the signed copy to me will evidence your agreement with the terms and conditions set forth in this letter. Please return a copy of the offer letter to me in the addressed/stamped envelope provided. This
offer will expire on April 10, 2012 unless accepted by you in writing prior to such date. 
 We genuinely hope that you decide to join the
Rib-X Pharmaceuticals team and look forward to your arrival soon. 
  

							
	Sincerely,	 		 		 	
				
	 /s/ Mark Leuchtenberger
 Mark
Leuchtenberger
	 		 		 	 /s/ Colleen Wilson
 Colleen
Wilson

	President & CEO	 		 		 	Director, Human Resources
				
	Accepted and Agreed To:	 		 		 	
			
	 /s/ Matthew A. Wikler
 Signature
	 		 	 April 30, 2012
 Anticipated Start Date

				
	 April 8, 2012
 Date

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