Document:

Exhibit 10.7

 Exhibit 10.7 
 LIPOSCIENCE, INC. 
 SECOND AMENDED AND RESTATED 

INVESTOR RIGHTS AGREEMENT 
 This Second Amended and Restated Investor Rights Agreement (the “Agreement”) is entered into as of August 2, 2006, by and among LipoScience, Inc., a Delaware corporation (formerly known as
LipoMed, Inc.) (the “Company”), the holders of the Company’s Series D Preferred Stock (the “Series D Stock”) and Series D-1 Preferred Stock (the “Series D-1 Stock”) listed on Exhibit A attached hereto
(collectively, the “Series D Investors”), the holders of the Company’s Series E Preferred Stock (the “Series E Stock”) listed on Exhibit B attached hereto (the “Series E Investors”), the holders of the
Series F Preferred Stock (the “Series F Stock”) listed on Exhibit C attached hereto, and those persons listed on Exhibit D attached hereto (each individually a “Common Holder” and collectively the “Common
Holders”). The Series D Investors, the Series E Investors and the Series F Investors shall be referred to herein collectively as the “Investors.” The Series D Stock, the Series D-1 Stock, the Series E Stock, the Series F Stock, the
Warrants (as defined below) and the Warrant Shares (as defined below) shall be referred to herein collectively as “Investor Securities.” 
 WHEREAS, the Company, the Series D Holders (as hereinafter defined) and the Common Holders entered into that certain Investor Rights Agreement, dated as of December 22, 2000, as amended (the
“2000 Agreement”); and 
 WHEREAS, the Company, the Series D Holders (as hereinafter defined), the Series E Holders
(as hereinafter defined) and the Common Holders entered into that certain Amended and Restated Investor Rights Agreement, dated as of May 7, 2003, as amended (which amended and restated the 2000 Agreement) (the “Prior Agreement”); and

 WHEREAS, the Company proposes to sell and issue up to 2,988,506 shares of Series F Stock, pursuant to that certain Series F
Preferred Stock Purchase Agreement, dated as of the date hereof, by and among the Company and the Series F Investors (the “Purchase Agreement”); and 
 WHEREAS, the Series F Investors, as a condition to entering into the Purchase Agreement, have requested that the Company provide the Series F Investors certain registration rights and certain other rights
with respect to the Series F Stock as set forth herein; and 
 WHEREAS, the amendment and restatement of the Prior Agreement
contemplated hereby requires the written consent of (i) the Investors holding at least a majority of the shares of Series D Stock, Series D-1 Stock and Series E Stock (the “Requisite Investors”) and (ii) the Company and execution
of this Agreement by the undersigned Requisite Investors and the Company satisfies such requirement; and 
 WHEREAS, in order to
induce the Company and the Series F Investors to enter into the Purchase Agreement, the Company, the Series F Investors, and the Requisite Investors hereby agree that this Agreement shall amend and restate the Prior Agreement and shall extend to the
Company, the Common Holders and the Investors the rights and obligations as set forth below. 

 NOW, THEREFORE, in consideration of the mutual agreements, covenants and conditions
contained herein, the Company, the Investors and the Common Holders hereby agree as follows. 
 Section 1. 

RESTRICTIONS ON TRANSFER 
 1.1 Restrictive Legend. Each certificate representing (i) the Investor Securities, (ii) the Common Stock of the Company (the “Common Stock”) issued upon conversion of the
Investor Securities, and (iii) any other securities issued in respect of the Investor Securities or Common Stock issued upon conversion of the Investor Securities upon any stock split, stock dividend, recapitalization, merger, consolidation or
similar event, shall (unless otherwise permitted by the provisions of this Section 1.1 or Section 1.2 below) be stamped or otherwise imprinted with a legend in substantially the following form (in addition to any legend required under
applicable state securities laws). 
 “THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE SOLD, MORTGAGED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND ANY APPLICABLE STATE SECURITIES LAWS, OR THE AVAILABILITY OF AN EXEMPTION FROM THE REGISTRATION PROVISIONS OF THE SECURITIES ACT OF
1933, AS AMENDED, AND APPLICABLE STATE SECURITIES LAWS. COPIES OF THE STOCK PURCHASE AGREEMENT AND THE SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT PROVIDING FOR RESTRICTIONS ON TRANSFER OF THESE SECURITIES MAY BE OBTAINED UPON WRITTEN
REQUEST BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF THE CORPORATION AT THE PRINCIPAL EXECUTIVE OFFICES OF THE CORPORATION.” 
 Each Holder (as defined below) consents to the Company’s making a notation on its records and giving instructions to any transfer agent of the Investor Securities or the Common Stock issued upon
conversion of the Investor Securities in order to implement the restrictions on transfer established in this Section 1. Such legend shall be removed by the Company from any certificate at such time as the holder of the shares represented by the
certificate satisfies the requirements of Rule 144(k) (“Rule 144(k)”) of the Securities Act of 1933, as amended (the “1933 Act”), provided that Rule 144(k) as then in effect does not differ substantially from Rule 144(k) as in
effect as of the date of this Agreement, and provided further that the Company has received from the Holder a written representation that (i) such Holder is not an affiliate of the 

  
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Company and has not been an affiliate during the preceding three months, (ii) such Holder has beneficially owned the shares represented by the certificate for a period of at least two years,
(iii) such Holder otherwise satisfies the requirements of Rule 144(k) as then in effect with respect to such shares, and (iv) such Holder will submit the certificate for any such shares to the Company for reapplication of the legend at
such time as the Holder becomes an affiliate of the Company or otherwise ceases to satisfy the requirements of Rule 144(k) as then in effect. 
 1.2 Notice of Proposed Transfers. The Holder of each certificate representing Registrable Securities (as defined below) by acceptance thereof agrees to comply in all respects with the provisions of
this Section 1.2. Prior to any proposed sale, assignment, transfer or pledge of any Registrable Securities, unless there is in effect a registration statement under the 1933 Act covering the proposed transfer, the Holder thereof shall give
written notice to the Company of such Holder’s intention to effect such transfer, sale, assignment or pledge. Each such notice shall describe the manner and circumstances of the proposed transfer, sale, assignment or pledge in sufficient
detail, and, if reasonably requested by the Company, shall be accompanied at such Holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company
addressed to the Company, to the effect that the proposed transfer of the Registrable Securities may be effected without registration under the 1933 Act or (ii) a “no action” letter from the SEC (as defined below) to the effect that
the transfer of such securities without registration will not result in a recommendation by the staff of the Securities and Exchange Commission (the “SEC”) that action be taken with respect thereto, whereupon the holder of such Registrable
Securities shall be entitled to transfer such Registrable Securities in accordance with the terms of the notice delivered by the holder to the Company. The Company will not require such a legal opinion or “no action” letter in any
transaction in compliance with Rule 144 of the 1933 Act (“Rule 144”) or for a transfer by a Holder, (a) which is a partnership, to such partnership’s partners or employees or former employees or former partners or employees in
accordance with partnership interests and in accordance with the partnership’s agreement, (b) which is a limited liability company, to such limited liability company’s members or former members in accordance with their interests in
the limited liability company, (c) which is a corporation, to such corporation’s stockholders in accordance with their stock ownership, (d) to a subsidiary or affiliate of the Holder or (e) to the Holder’s family member or
trust for the benefit of an individual Holder; provided that in each case the transferee will be subject to the terms of this Agreement to the same extent as if he, she or it were an original Holder hereunder. Each certificate evidencing the
Registrable Securities transferred as above provided shall bear, except if such transfer is made pursuant to Rule 144, the appropriate restrictive legend set forth in Section 1.1 above, except that such certificate shall not bear such
restrictive legend if in the opinion of counsel for such Holder and the Company such legend is not required in order to establish compliance with any provisions of the 1933 Act. 

Section 2. 

REGISTRATION RIGHTS 
 The Company hereby grants to each of the Holders (as defined below) the registration rights set forth in this Section 2, with respect to the Registrable Securities (as defined below) owned by such
Holders. The Company and the Holders agree that the registration rights provided herein set forth the sole and entire agreement, and supersede any prior agreement, between the Company and the Holders with respect to registration rights for the
Company’s securities. 

  
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 2.1 Certain Definitions. As used in this Section 2: 

(a) The terms “register,” “registered” and “registration” refer to a registration effected
by filing with the SEC a registration statement (the “Registration Statement”) in compliance with the 1933 Act, and the declaration or ordering by the SEC of the effectiveness of such Registration Statement. 

(b) The term “Registrable Securities” means (i) Common Stock issued or issuable upon conversion of any
shares of Series D Stock, Series D-1 Stock, Series E Stock (including up to 646,724 shares of Series E Stock (the “Warrant Shares”) issuable upon the exercise of certain warrants the (“Warrants”) outstanding as of the date
hereof) and Series F Stock, held by the Investors or any transferee as permitted by Section 2.9 hereof, and (ii) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right or other security that is issued
as) a dividend or other distribution with respect to, or in exchange or in replacement of, such Registrable Securities; provided, however, that shares of Common Stock or other securities shall only be treated as Registrable Securities if and so long
as (A) they have not been sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction, (B) they have not been sold in a transaction exempt from the registration and prospectus delivery
requirements of the 1933 Act under Section 4(1) thereof so that all transfer restrictions and restrictive legends with respect thereto are removed upon the consummation of such sale, and (C) the registration rights associated with such
securities have not been terminated pursuant to Section 2.16 hereof. 
 (c) The term “Holder”
(collectively, “Holders”) means each Investor and any transferee, as permitted by Section 2.9 hereof, holding Registrable Securities, securities exercisable or convertible into Registrable Securities or securities exercisable for
securities convertible into Registrable Securities. 
 2.2 Demand Registration 

(a) Subject to the conditions of this Section 2.2, if the Company shall receive a written request from either
(i) the Holders of at least forty percent (40%) of the Registrable Securities then outstanding and held by the Holders of the Series D Investors and the Series E Investors, taken together, or (ii) the Holders of at least forty percent
(40%) of the Registrable Securities then outstanding and held on the date hereof by the Series F Investors (in either case, such Holders are hereinafter referred to as the “Initiating Holders”) that the Company file a registration
statement under the 1933 Act covering the registration of such Registrable Securities, then the Company shall promptly give written notice of such request to all Holders and Common Holders and, subject to the limitations of this Section 2.2 and
Section 2.15, use its best efforts to effect, as soon as practicable, the registration under the 1933 Act of all Registrable Securities that the Holders (including the Initiating Holders) request to be registered and all shares of Common Stock
that Common Holders request to be registered pursuant to Section 2.15. 

  
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 (b) If the Initiating Holders intend to distribute the Registrable
Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such
information in the written notice referred to in Section 2.2(a) or Section 2.4, as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s
participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an
underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by a majority in interest of the Initiating Holders (which underwriter or underwriters shall be reasonably acceptable to the Company).
Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities)
then the Company shall so advise all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to the Holders of such Registrable
Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders). Any Registrable Securities excluded or withdrawn from such underwriting shall be withdrawn from the
registration. If the underwriter has not limited the number of Registrable Securities to be underwritten, the Company may include securities for its own account (or for the account of other stockholders) in such registration if the underwriter so
agrees and if the number of Registrable Securities would not thereby be limited. 
 (c) The Company shall not be
required to effect a registration pursuant to this Section 2.2: 
 (i) prior to the earlier of (A) the
third anniversary of the date of this Agreement or (B) 180 days following the effective date of the registration statement pertaining to the Company’s first underwritten public offering of its Common Stock registered under the 1933 Act (an
“Initial Offering”); 
 (ii) on behalf of Holders of at least forty percent (40%) of the
Registrable Securities held by the Series D Investors and the Series E Investors, taken together after the Company has effected two (2) registrations pursuant to this Section 2.2 on their behalf, and such registrations have been declared
or ordered effective; provided, however, that a registration effected by the Company pursuant to this Section 2.2 in which such Holders are given the opportunity to include such Holder’s Registrable Securities (whether or not such Holders
were the Initiating Holders for such registration or elected to participate in such registration) shall qualify as a registration for purposes of this Subparagraph (c)(ii); 

(iii) on behalf of Holders of at least forty percent (40%) of the Registrable Securities held by the Series F
Investors after the Company has effected two (2) registrations pursuant to this Section 2.2 on their behalf, and such registrations have been declared or ordered effective; provided, however, that a registration effected by the Company
pursuant to this Section 2.2 in which such Holders are given the opportunity to include such Holder’s Registrable Securities, without being subject to cutbacks or similar limitations, shall qualify as a registration for purposes of this
Subparagraph (c)(iii); 

  
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 (iv) during the period starting thirty (30) days prior to the date of
filing of, and ending on the date one hundred eighty (180) days following the effective date of a registration statement pertaining to a public offering of the Company’s securities in which the Holders have the right to register the
Registrable Securities pursuant to Section 2.3; provided that the Company makes reasonable good faith efforts to cause such registration statement to become effective; 

(v) if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 2.2, a
certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration
statement to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than one hundred twenty (120) days after receipt of the request of the Initiating Holders; provided that
such right to delay a request shall be exercised by the Company not more than once in any twelve (12) month period; 
 (vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below; or

 (vii) in any particular jurisdiction in which the Company would be required to qualify to conduct business or
execute a general consent to service of process in effecting such registration, qualification or compliance unless the Company is already so qualified or subject to service in such jurisdiction. 

2.3 Piggyback Registration. 
 (a) Notice of Registration. If at any time or from time to time the Company shall determine to register any of its securities, either for its own account or for the account of security holders,
other than a registration relating solely to employee benefit plans, a registration on Form S-4 relating solely to an SEC Rule 145 transaction or a registration pursuant to Section 2.2 hereof, the Company will: 

(i) promptly (but in any event 10 days prior to the filing of any such registration statement) give to each Holder written
notice thereof; and 
 (ii) include in such registration (and any related qualification under state securities
laws or other compliance), and in any underwriting involved therein, all the Registrable Securities specified in a written request or requests, made within 15 days after receipt of such written notice from the Company, by any Holder or Holders,
except as set forth in Section 2.3(b) below. 

  
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 Such Registrable Securities shall only be included in any registration pursuant to this
Section 2.3 to the extent that such inclusion will not diminish the number of securities included by the Company. 
 (b) Underwriting. If the registration of which the Company gives notice is for a registered public offering involving an underwriting, the Company shall so advise the Holders as a part of the
written notice given pursuant to Section 2.3(a)(i). In such event the right of any Holder to registration pursuant to this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of
such Holder’s Registrable Securities in the underwriting to the extent provided herein. 
 All Holders proposing to
distribute their Registrable Securities through such underwriting shall, together with the Company and the other parties distributing their securities through such underwriting, enter into an underwriting agreement in customary form with the
underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Section 2.3, if the underwriter determines in good faith that marketing factors require a limitation of the number of shares
to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders;
and third, to any stockholder of the Company (other than a Holder) on a pro rata basis, provided, however, that no such reduction shall reduce the amount of securities of the selling Holders included in the registration below twenty-five
percent (25%) of the total amount of securities included in such registration, unless such offering is the Initial Offering and such registration does not include shares of any other selling stockholders, in which event any or all of the
Registrable Securities of the Holders may be excluded in accordance with this sentence. In no event will shares of any other selling stockholder be included in such registration which would reduce the number of shares which may be included by
Holders without the written consent of Holders of not less than a majority of the Registrable Securities proposed to be sold in the offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw
therefrom by written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall
be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and stockholders of such Holder, or the estates and family members of any such partners and retired partners and
any trusts for the benefit of any of the foregoing persons shall be deemed to be a single “Holder”, and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares
carrying registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence. 
 (c) Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such
registration whether or not any Holder has elected to include securities in such registration. The registration expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof. 

  
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 2.4 Form S-3 Registration. In the event the Company shall receive from the Initiating
Holders a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3) or any similar short-form registration statement and any related qualification or compliance with respect to all or a part
of the Registrable Securities owned by such Holder or Holders, the Company will: 
 (a) promptly give written
notice of the proposed registration, and any related qualification or compliance, to all other Holders of Registrable Securities; and 
 (b) as soon as practicable, effect such registration and all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion
of such Holder’s or Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written
request given within fifteen (15) days after receipt of such written notice from the Company as specified above in 2.4(a); provided, however, that the Company shall not be obligated to effect any such registration, qualification or
compliance pursuant to this Section 2.4: 
 (i) if Form S-3 (or any successor or similar form) is not
available for such offering by the Holders; or 
 (ii) if the Holders, together with the holders of any other
securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) in such registration at an aggregate price to the public of less than one million dollars ($1,000,000);
or 
 (iii) during the period starting sixty (60) days prior to the date of filing of, and ending on the
date one hundred eighty (180) days following the effective date of a registration statement pertaining to a public offering of the Company’s securities in which the Holders have the right to register the Registrable Securities pursuant to
Section 2.3; provided that the Company makes reasonable good faith efforts to cause such registration statement to become effective; or 
 (iv) if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of the
Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration
statement for a period of not more than one hundred twenty (120) days after receipt of the request of the Holder or Holders under this Section 2.4; provided, that such right to delay a request shall be exercised by the Company not
more than once in any twelve (12) month period; or 
 (v) if the Company has, within the twelve
(12) month period preceding the date of such request, already effected two (2) registrations on Form S-3 for the Holders pursuant to Section 2.4; or 

  
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 (vi) in any particular jurisdiction in which the Company would be required
to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance unless the Company is already so qualified or subject to service in such jurisdiction. 

(c) Subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities
and other securities so requested to be registered as soon as practicable after receipt of the request or requests of the Holders under this Section 2.4. Registrations effected pursuant to this Section 2.4 shall not be counted as demands
for registration or registrations effected pursuant to Section 2.2 hereof. 
 2.5 Expenses of Registration. All
expenses incurred in connection with all registrations effected pursuant to Sections 2.2, 2.3 and 2.4, including, without limitation, all registration, filing and qualification fees (including state securities law fees and expenses), printing
expenses, escrow fees, fees and disbursements of counsel for the Company and expenses of any special audits incidental to or required by such registration shall be borne by the Company; provided, however, that the Company shall not be required to
pay stock transfer taxes or underwriters’ discounts or selling commissions relating to Registrable Securities; and provided, further, that the Company shall not be required to pay for any expenses of any registration pursuant to
Section 2.4 after the Company has effected two (2) registrations pursuant to Section 2.4, in which event the Holders of Registrable Securities to be registered shall bear all such expenses pro rata on the basis of the Registrable
Securities to be registered. 
 2.6 Obligations of the Company. Whenever required under this Section 2 to effect the
registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (a)
prepare and file with the SEC a Registration Statement with respect to such Registrable Securities and use its diligent efforts to cause such Registration Statement to become effective, and keep such Registration Statement effective for the lesser
of 180 days or until the Holder or Holders have completed the distribution relating thereto; provided, however, that the Company shall have the right to terminate such Registration Statement, or to place a stop-transfer order with respect to the
shares for which registration has been requested thereunder, upon notice to the participating Holders to the extent necessary, in the sole discretion of the Company upon the advice of counsel, to avoid any requirement that the Company disclose
material, nonpublic information, the disclosure of which would be seriously detrimental to the Company and its stockholders, provided, further, that (i) such 180-day period shall be extended for a period of time equal to the period the Holder
refrains from selling any securities included in such registration at the request of an underwriter of Common Stock (or other securities) of the Company; and (ii) in the case of any registration of Registrable Securities on Form S-3 which are
intended to be offered on a continuous or delayed basis, such 180-day period shall be extended, if necessary, to keep the registration statement effective until all such Registrable Securities are sold, provided that Rule 415, or any successor rule
under the 1933 Act, permits an offering on a continuous or delayed basis, and provided further that applicable rules under the 1933 Act governing the obligation to file a post-effective amendment permit, in lieu of filing a post-effective amendment
which (I) includes any prospectus required by Section 10(a)(3) of the Act, 

  
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or (II) reflects facts or events representing a material or fundamental change in the information set forth in the registration statement, the incorporation by reference of information required
to be included in (I) and (II) above to be contained in periodic reports filed pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, in the registration statement; and provided further that in no event shall
the Company be required to keep any such Registration Statement effective for longer than eighteen (18) months. 
 (b) prepare and file with the SEC such amendments and supplements to such Registration Statement and the prospectus used in connection with such Registration Statement as may be necessary to keep such
Registration Statement effective and to comply with the provisions of the 1933 Act with respect to the disposition of all securities covered by such Registration Statement. 

(c) furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus, in conformity with
the requirements of the 1933 Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

(d) use its diligent efforts to register or otherwise qualify the securities covered by such Registration Statement under
such other securities laws of such states and other jurisdictions as shall be reasonably requested by the Holders or the managing underwriter, provided that the Company shall not be required in connection therewith or as a condition thereto to
qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 

(e) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting
agreement, in usual and customary form, with the managing underwriter of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 

(f) notify each Holder of Registrable Securities covered by such Registration Statement, at any time when a prospectus
relating thereto is required to be delivered under the 1933 Act, of the happening of any event as a result of which the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits
to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing and, in the Company’s reasonable discretion, the Company shall prepare a
supplement or amendment to such prospectus so that, as thereafter delivered to the purchasers of such Registrable Securities, such prospectus shall not contain an untrue statement of material fact or omit to state any fact necessary to make the
statements therein, in light of the circumstances under which they were made, not misleading. 
 (g) use its
diligent efforts to list the Registrable Securities covered by such Registration Statement with any securities exchange on which the Common Stock is then listed. 

(h) make available for inspection by each Holder including Registrable Securities in such registration, any underwriter
participating in any distribution pursuant to such registration, and any attorney, accountant or other agent retained by such Holder or underwriter, 

  
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all financial and other records, pertinent corporate documents and properties of the Company, as such parties may reasonably request, and cause the Company’s officers, directors and
employees to supply all information reasonably requested by any such Holder, underwriter, attorney, accountant or agent in connection with such Registration Statement. 

(i) cooperate with the Holders including Registrable Securities in such registration and the managing underwriters, if
any, to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold, such certificates to be in such denominations and registered in such names as such Holders or the managing underwriters may
request at least two business days prior to any sale of Registrable Securities. 
 (j) permit any Holder, which
Holder, in the sole and exclusive judgment, exercised in good faith, of such Holder, might be deemed to be a controlling person of the Company, to participate in good faith in the preparation of such Registration Statement and to require the
insertion therein of material, furnished to the Company in writing, that in the reasonable judgment of such Holder and its counsel should be included. 
 2.7 Indemnification. 
 (a) The Company will, and does hereby
undertake to, indemnify and hold harmless each Holder of Registrable Securities, each of such Holder’s officers, directors, managers, partners, members and agents, and each person controlling such Holder, with respect to any registration,
qualification or compliance effected pursuant to this Section 2, and each underwriter, if any, and each person who controls any underwriter, of the Registrable Securities held by or issuable to such Holder, against all claims, losses, damages
and liabilities (or actions in respect thereto) to which they may become subject under the 1933 Act, the Securities Exchange Act of 1934, as amended (the “1934 Act”), or other federal or state law arising out of or based on (i) any
untrue statement (or alleged untrue statement) of a material fact contained in any prospectus, offering circular or other similar document (including any related Registration Statement, notification, or the like) incident to any such registration,
qualification or compliance, or based on any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances in which they were
made, or (ii) any violation or alleged violation by the Company of any federal, state or common law rule or regulation applicable to the Company in connection with any such registration, qualification or compliance, and will reimburse, as
incurred, each such Holder, each such underwriter and each such director, manager, officer, partner, member, agent and controlling person, for any legal and any other expenses reasonably incurred in connection with investigating or defending any
such claim, loss, damage, liability or action; provided that the Company will not be liable in any such case to an indemnified party to the extent that any such claim, loss, damage, liability or expense arises out of or is based on any untrue
statement or omission made in conformity with written information furnished to the Company by an instrument duly executed by such indemnified party specifically for use therein. 

(b) Each Holder will, severally and not jointly, and if Registrable Securities held by or issuable to such Holder are
included in such registration, qualification or compliance pursuant to this Section 2, does hereby undertake to indemnify and hold harmless the Company, each of its directors and officers, and each person controlling the Company, each
underwriter, if 

  
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any, and each person who controls any underwriter, of the Company’s securities covered by the Registration Statement relating to such registration, qualification or compliance, and each
other Holder, each of such other Holder’s officers, directors, managers, partners, members and agents and each person controlling such other Holder, against all claims, losses, damages and liabilities (or actions in respect thereof) arising out
of or based on (i) any failure of such Holder or its agents or representatives to comply with the prospectus delivery requirements of the 1933 Act or any other applicable securities or Blue Sky law, or (ii) any untrue statement (or alleged
untrue statement) of a material fact contained in any such Registration Statement, prospectus, offering circular or other document, or any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to
make the statements therein not misleading in light of the circumstances in which they were made, and will reimburse, as incurred, the Company, each such underwriter, each such other Holder, and each such director, officer, manager, partner, member,
agent and controlling person of the foregoing, for any legal or any other expenses reasonably incurred in connection with investigating or defending any such claim, loss, damage, liability or action; provided, that, if the indemnification
obligations shall have arisen under (ii) above, such indemnifying Holder will have indemnification obligations hereunder only to the extent that such untrue statement (or alleged untrue statement) or omission (or alleged omission) was made in
such Registration Statement, prospectus, offering circular or other document, in reliance upon and in conformity with written information furnished to the Company by an instrument duly executed by such Holder and stated to be specifically for use
therein; provided, however, that the liability of each Holder hereunder (unless such Holder’s liability hereunder is based upon such Holder’s willful misconduct) shall be limited to the proportion of any such claim, loss, damage or
liability that is equal to the proportion that the public offering price of the shares sold by such Holder under such Registration Statement bears to the total public offering price of all securities sold thereunder, but in any event not to exceed
the net proceeds received by such Holder from the sale of securities under such Registration Statement. 
 (c)
Each party entitled to indemnification under this Section 2.7 (the “Indemnified Party”) shall give notice to the party required to provide such indemnification (the “Indemnifying Party”) of any claim as to which
indemnification may be sought promptly after such Indemnified Party has actual knowledge thereof, and shall permit the Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom; provided that counsel for the
Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be subject to approval by the Indemnified Party (whose approval shall not be unreasonably withheld) and the Indemnified Party may participate in such defense at the
Indemnified Party’s expense if representation of such Indemnified Party would be inappropriate due to actual or potential differing interests between such Indemnified Party and any other party represented by such counsel in such proceeding; and
provided further that the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Section 2, except to the extent that such failure to give notice shall
materially adversely affect the Indemnifying Party in the defense of any such claim or any such litigation. An Indemnifying Party, in the defense of any such claim or litigation, may, without the consent of each Indemnified Party, consent to entry
of any judgment or enter into any settlement only if it includes as an unconditional term thereof the giving by the claimant or plaintiff therein, to such Indemnified Party, of a release from all liability with respect to such claim or litigation.
The Indemnifying Party shall have no liability under this Section 2.7 for any settlement effected by 

  
 12 

 
an Indemnified Party without the written consent of the Indemnifying Party (which consent shall not be unreasonably withheld) except in the event that the Indemnifying Party fails to diligently
undertake the defense of the claim or litigation resulting in such settlement after notice is provided as set forth herein. 
 (d) In order to provide for just and equitable contribution to joint liability under the 1933 Act in any case in which either (i) any Holder exercising rights under this Agreement, or any controlling
person of any such Holder, makes a claim for indemnification pursuant to this Section 2.7 but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or
the denial of the last right of appeal) that such indemnification may not be enforced in such case notwithstanding the fact that this Section 2.7 provides for indemnification in such case, or (ii) contribution under the 1933 Act may be
required on the part of any such Holder or any such controlling person in circumstances for which indemnification is provided under this Section 2.7; then, and in each such case, the Company and such Holder will contribute to the aggregate
claims, losses, damages or liabilities to which they may be subject (after contribution from others) in such proportions as shall be appropriate to reflect the relative fault of the Company, on the one hand, and each such Holder, on the other hand,
with such relative fault determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company or
by each such Holder, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, however, that, in any case, (A) no such Holder will be required to
contribute any amount in excess of the public offering price of all securities offered by it pursuant to such Registration Statement, after deduction of underwriting discounts and commissions (unless such Holder’s liability hereunder is based
upon such Holder’s willful misconduct); and (B) no person or entity guilty of fraudulent misrepresentation (within the meaning of Section 11 (f) of the 1933 Act) will be entitled to contribution from any person or entity who was
not guilty of such fraudulent misrepresentation. 
 (e) The indemnities provided in this Section 2.7 shall
survive the transfer of any Registrable Securities by such Holder, whether pursuant to a Registration Statement under this Agreement or otherwise. 
 2.8 Information by Holder. The Holder or Holders of Registrable Securities included in any registration shall furnish to the Company such information regarding such Holder or Holders and the
distribution proposed by such Holder or Holders as the Company may reasonably request in writing and as shall be required in connection with any registration, qualification or compliance referred to in this Section 2. The Company shall not be
required to include any Holder’s Registrable Securities in any registration hereunder unless such information shall have been provided. 
 2.9 Transfer of Rights. The rights contained in Sections 2 and 3 hereof may be assigned or otherwise conveyed to transferees or assignees of Registrable Securities, who shall be considered a
“Holder” for purposes hereof, provided that such transfer is effected in compliance with Section 1.2 hereof and such transfer is a “Permitted Transfer” as defined herein. 

  
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 For purposes of this Agreement, a “Permitted Transfer” shall mean:
(i) a transaction not involving a change in beneficial ownership; (ii) transactions involving distributions or transfers by a stockholder that is a partnership, limited liability company or corporation to (A) any of its partners
(including limited partners), members or stockholders (as the case may be), (B) any of its retired partners, members or stockholders, (C) any of its affiliates, or (D) the estate of any of its partners (including limited partners),
members or stockholders; (iii) transactions involving distribution without consideration by a stockholder that is a corporation to any of its stockholders; (iv) transfers by any stockholder who is an individual to a trust for the benefit
of such stockholder or his family; (v) a transfer in which the transferee acquires at least 25% of the transferor’s shares of Registrable Securities, subject to adjustments for combinations, consolidations, recapitalizations, stock splits,
stock dividends and the like; or (vi) transfers by gift, will or intestate succession to the spouse, lineal descendants, whether by blood or by adoption, spouses of such descendants, ancestors, siblings, or direct lineal descendants, whether by
blood or by adoption, of such siblings, of any stockholder or spouse of a stockholder or a trust or family limited partnership for the sole benefit of such persons. 
 2.10 Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result of any controversy that might arise
with respect to the interpretation or implementation of this Section 2. 
 2.11 Subsequent Registration Rights. From
and after the date hereof, the Company shall not, without the prior written consent of the Holders of (i) a majority of the Common Stock issued or issuable upon conversion of the Investor Securities then outstanding, and (ii) a majority of
the Registrable Securities then held by the Series F Investors, enter into any agreement with any holder or prospective holder of any securities of the Company that would grant such holder registration rights senior to or on parity with those
granted to the Holders hereunder. 
 2.12 Rule 144 Reporting. With a view to making available to the Holders the benefits
of certain rules and regulations of the SEC that may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its diligent efforts to: 

(a) Make and keep current public information available, within the meaning of SEC Rule 144 or any similar or analogous
rule promulgated under the 1933 Act, at all times after it has become subject to the reporting requirements of the 1934 Act; 
 (b) File with the SEC, in a timely manner, all reports and other documents required of the Company under the 1933 Act and 1934 Act (after it has become subject to such reporting requirements); 

(c) So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request a written statement
by the Company as to its compliance with the reporting requirements of said Rule 144 (at any time commencing 90 days after the effective date of the Initial Offering), the 1933 Act and the 1934 Act (at any time after it has become subject to such
reporting requirements); a copy of the most recent annual or quarterly report of the Company; and such other reports and documents as a Holder may reasonably request in availing itself of any rule or regulation of the SEC allowing it to sell any
such securities without registration. 

  
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 2.13 “Market Stand-Off” Agreement. Each Holder hereby agrees that during a
period, not to exceed 180 days, following the effective date of any registration statement of the Company filed under the 1933 Act in connection with the Company’s Initial Offering, it shall not, to the extent requested by the Company and any
underwriter, sell, pledge, transfer, make any short sale of, loan, grant any option for the purchase of, or otherwise transfer or dispose of (other than to donees who agree in writing to be similarly bound) any securities of the Company held by it
at any time during such period except any Common Stock which may be included in such registration; provided, however, that no Holders shall have any such obligations unless all “One Percent Stockholders” with registration rights (whether
or not pursuant to this Agreement) and all officers and directors of the Company enter into similar agreements. 
 For purposes
of this Section 2.13, the term “One Percent Stockholder” shall mean a stockholder of the Company who holds at least one percent of the outstanding Common Stock of the Company (assuming conversion of all outstanding convertible
securities of the Company). 
 In order to enforce the foregoing covenant, the Company may impose stop transfer instructions
with respect to the Registrable Securities of each Holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 

2.14 Amendment of Registration Rights. Any provision of this Section 2 may be amended and the observance thereof may be
waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of (i) the Company, (ii) the Holders of at least a majority of the Registrable Securities then outstanding and
not registered, and (iii) the Holders of at least a majority of the Registrable Securities then held by the Series F Investors. Any amendment or wavier effected in accordance with this Section shall be binding upon each Holder, each future
Holder of Registrable Securities and the Company. 
 2.15 Inclusion of Stock Held by Common Holders. In connection with
any registration effected pursuant to Section 2.2 or Section 2.3 hereof, the Common Holders shall be entitled to include in such registration (on the same terms and conditions as Holders selling their Registrable Securities in such
registration) shares of Common Stock held by such Common Holders; provided that no Common Holder shall have the right to initiate a request for registration under Section 2.2 (unless otherwise a holder of Registrable Securities) and any
limitation by the underwriter on the number of shares to be underwritten in connection with any such registration pursuant to Section 2.2 or 2.3 hereof shall be applied to the shares of Common Stock so included by such Common Holders before any
limitation is applied to any Registrable Securities, and no Registrable Securities shall be excluded from the registration unless all shares held by Common Holders (other than Registrable Securities) are also excluded, and provided further
that each such Common Holder’s right to include shares of Common Stock in a registration pursuant to this Section 2.15 is contingent upon such Common Holder’s agreement (as evidenced by signing this Agreement) to be bound by all other
applicable restrictions and obligations contained in this Section 2 with respect to Holders, as if such Common Holder were a Holder hereunder (including, without limitation, the provisions of Section 2.13 hereof). 

2.16 Termination of Rights. The rights of any particular Holder to cause the Company to register securities under Section 2
hereof shall terminate as to such Holder upon the later to occur of (i) three (3) years after the date of the closing of the Company’s Initial Offering or 

  
 15 

 
(ii) the time that (a) the Company has completed its Initial Offering and is subject to the provisions of the 1934 Act, (b) such Holder holds less than 1% of the Company’s
outstanding Common Stock (treating all shares of the Company’s Preferred Stock on an as-converted basis) and (c) all Registrable Securities held by and issuable to such Holder (and its affiliates, partners, former partners, members and
former members) which may be required to be aggregated with such Holder’s Registrable Securities under Rule 144 may be sold under Rule 144 during any ninety (90) day period. 

Section 3. 

RIGHTS OF FIRST REFUSAL 
 3.1 Certain Definitions. As used in this Section 3: 

(a) The term “New Securities” shall mean any capital stock of the Company, whether now authorized or not, and
rights, options or warrants to purchase capital stock, and securities of any type whatsoever that are, or may become, convertible into capital stock; provided that the term “New Securities” does not include: (i) the Investor
Securities; (ii) securities issuable upon conversion, exchange or exercise of or with respect to Investor Securities (including any securities issuable upon further exercise, exchange or conversion of the Investor Securities);
(iii) securities issuable upon conversion or exercise of any other preferred stock or warrant or debt security of the Company issued on or prior to the date hereof (including securities issuable upon further conversion of any such exercised
securities); (iv) shares of Common Stock and options, warrants or rights convertible into such Common Stock, issued or issuable to employees, consultants or directors of the Company pursuant to any incentive agreement or arrangement approved by
the Board of Directors of the Company in an aggregate amount of not more than 4,580,000 shares or such higher number of shares as may be approved by the Board of Directors, including at least two (2) of the directors designated by the holders
of Series D Stock, Series E Stock and Series F Stock pursuant to Section 5.3 of this Agreement, appropriately adjusted for any stock split, stock dividend or other recapitalization; (v) shares of capital stock or securities exercisable for
or convertible into such capital stock issued in connection with any equipment leases or borrowings, direct or indirect, from financial or other institutions regularly engaged in such business as may be approved by the Board of Directors;
(vi) securities issued pursuant to any stock dividend, stock split, combination or other reclassification by the Company of any of its capital stock; (vii) securities issued pursuant to the acquisition of another corporation or business
entity by the Company or one or more of its wholly owned subsidiaries by merger, consolidation, share exchange, purchase of substantially all the assets or other reorganization whereby the stockholders of the Company immediately prior to the
transaction own in the aggregate more than 50% of the voting power of the Company or other surviving entity after the transaction; (viii) any performance based equity issued in connection with strategic relationships or similar arrangements
approved by the Company’s Board of Directors; or (ix) shares of capital stock or securities exercisable for or convertible into such capital stock issued to the Company’s chief executive officer in connection with a stock or warrant
bonus plan pursuant to that certain letter agreement by and between the Company and Richard O. Brajer dated February 6, 2003. 

  
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 (b) The term “Pro Rata Share” means the ratio (A) the
numerator of which is the number of shares of Common Stock held by such Investor, or issuable to such Investor upon the conversion or exercise of all securities convertible into or exercisable for Common Stock of the Company held by such Investor,
on the date of the written notice pursuant to Section 3.2 hereof, and (B) the denominator of which is, with respect to the right of first refusal set forth in Section 3.2, the number of shares of Common Stock outstanding, assuming for
this purpose conversion or exercise of all securities convertible into or exercisable for Common Stock of the Company. 
 3.2
Right of First Refusal. The Company hereby grants to each Investor, subject to the terms and conditions specified in this Section 3.2, the right of first refusal to purchase, on the terms and conditions set forth in the Company’s
notice pursuant to this Section 3.2, up to such Investor’s Pro Rata Share of all New Securities that the Company may, from time to time, propose to sell and issue. In the event the Company proposes to undertake an issuance of New
Securities, it shall give each Investor written notice of its intention, describing the type of New Securities, the price and the general terms upon which the Company proposes to issue the same. Each Investor shall have 20 days from the date of any
such notice to exercise its right of first refusal under this Section 3.2 for the price and upon the general terms specified in the notice by giving written notice to the Company and stating therein the quantity of New Securities to be
purchased. The Company shall have 75 days after the 20-day period described in this Section 3.2 to sell all such New Securities respecting which the Investors’ rights of first refusal hereunder were not exercised, at a price and upon terms
no more favorable in any material respect to the purchasers thereof than specified in the Company’s notice. In the event the Company has not sold all such New Securities within such 75-day period, the Company shall not thereafter issue or sell
any New Securities without first notifying the Investors in the manner provided herein. 
 3.3 Expiration of Right. The
rights of first refusal granted under this Section 3 shall not apply to, and shall expire upon, the effectiveness of a registration statement for the sale of the Company’s shares of Common Stock in an underwritten public offering
registered under the 1933 Act (a “Qualified Public Offering”). 

  
 17 

 Section 4. 
 COMPANY COVENANTS 
 The Company hereby covenants and agrees as follows:

 4.1 Financial Information. 
 (a) So long as any Investor or any subsidiary, affiliate or partner of such Investor shall own at least 30% of the Investor Securities originally acquired by such Investor (including any shares of Common
Stock or preferred stock of the Company (“Preferred Stock”) issued upon conversion or exercise thereof, and subject to adjustment for combinations, consolidations, recapitalizations, stock splits, stock dividends and similar events), the
Company will furnish each such Investor, subject to Section 4.1(c) below, the following reports: 
 (i) As
soon as practicable after the end of each fiscal year, and in any event within 120 days thereafter, (1) audited consolidated balance sheets of the Company and its subsidiaries, if any, as at the end of such fiscal year, and audited consolidated
statements of income and losses, stockholders’ equity and cash flows of the Company and its subsidiaries, if any, for such fiscal year, prepared in accordance with generally accepted accounting principles and setting forth in each case in
comparative form the figures for the previous fiscal year, if any, all in reasonable detail and accompanied by a report and opinion thereon by independent auditors selected by the Company’s Board of Directors; and (2) a copy of such
auditors’ management letter prepared in connection therewith, if any, (as soon as such management letter is available, which may be greater than the aforesaid 120-day period); 

(ii) As soon as practicable after the end of each of the first three quarters of the fiscal year, but in any event within
45 days after the end of each such quarter, the unaudited consolidated balance sheets of the Company and its subsidiaries, if any, as of the end of such quarter, and its unaudited consolidated statements of income and losses, stockholders’
equity and cash flows for such quarter, setting forth in each case in comparative form the figures for the corresponding period of the preceding fiscal year, all in reasonable detail and prepared in accordance with generally accepted accounting
principles, except that such financial statements may not contain notes and will be subject to year-end adjustment, and certified by the principal financial or accounting officer of the Company. Such quarterly report shall include a narrative,
summary description of the Company’s operations for such quarter, indicating whether the Company is materially in compliance with this Agreement and other material agreements and discussing any material variances from the Company’s
operating plan for such fiscal year; 
 (iii) As soon as practicable after the adoption thereof, an annual
operating plan for each fiscal year; and 
 (iv) With reasonable promptness, such other information respecting
the business, properties or the condition or operations, financial or other, of the Company or any subsidiary as any Investor may from time to time reasonably request. 

  
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 (b) So long as any Series F Investor or any subsidiary, affiliate or partner
of such Investor shall own at least 30% of the Investor Securities originally acquired by such Series F Investor, the Company will furnish each such Series F Investor, subject to Section 4.1(c) below, as soon as practicable after the end of
each month, but in any event within 45 days after the end of such month, unaudited consolidated balance sheets of the Company and its subsidiaries, if any, as of the end of such month, and its unaudited consolidated statements of income and losses,
stockholders’ equity and cash flows for such month, setting forth in each case in comparative form the figures for the corresponding period of the preceding fiscal year, all in reasonable detail and prepared in accordance with generally
accepted accounting principles, except that such financial statements may not contain notes and will be subject to year-end adjustment, and certified by the principal financial or accounting officer of the Company. Such monthly report shall include
a narrative, summary description of the Company’s operations for such month, indicating whether the Company is materially in compliance with this Agreement and other material agreements and discussing any material variances from the
Company’s operating plan for such fiscal year. 
 (c) The Company shall not be obligated pursuant to this
Section 4.1 to provide financial information to any person whom the Company reasonably believes to be engaged in the business of developing, manufacturing or selling products or services competitive with those of the Company (a
“Competitor”). 
 (d) The rights granted pursuant to this Section 4.1 may not be assigned or
otherwise conveyed by any Investor or by any subsequent transferee of any such rights without the prior written consent of the Company, which consent shall not be unreasonably withheld; provided that the Company may refuse such written consent if
the proposed transferee is reasonably believed by the Board of Directors of the Company to be a Competitor. 
 4.2
Inspection. The Company shall permit each Investor and each transferee in a Permitted Transfer (as defined in Section 2.9 hereof) (provided such transfer is effected in compliance with Section 1.2 hereof), its attorney or its other
representative to visit and inspect the Company’s properties, to examine the Company’s books of account and other records, to make copies or extracts therefrom and to discuss the Company’s affairs, finances and accounts with its
officers, management, employees and independent auditors all at such reasonable times and as often as such Investor or transferee may reasonably request; provided, however, that the Company shall not be obligated pursuant to this Section 4.2 to
provide trade secrets or confidential information or to provide information to any person whom the Board of Directors of the Company reasonably believes is a Competitor; provided, further, that such Investor shall bear any costs or expenses of such
investigations or inquiries. 

  
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 4.3 Additional Affirmative Covenants. Without limiting any other covenant or
provision hereof, the Company covenants and agrees that, so long as shares representing at least 14% of the Series D Stock and Series D-1 Stock (taken together) outstanding as of the date hereof or 14% of the Series E Stock outstanding as of the
date hereof or 14% of the Series F Stock outstanding immediately subsequent to the final closing pursuant to the Purchase Agreement remain outstanding, subject to adjustment for combinations, stock splits, stock dividends and similar events, it
will, and will cause each subsidiary (to the extent applicable thereto) of the Company, if and when such subsidiary exists, to: 
 (a) Payment of Taxes. Pay, and cause each subsidiary to pay, and discharge all taxes, assessments and governmental charges or levies imposed upon it or upon its income, profits or business, or upon
any properties belonging to it, prior to the date on which penalties attach thereto, and all lawful claims that, if unpaid, might become a lien or charge upon any properties of the Company or any subsidiary, provided that neither the Company nor any
subsidiary shall be required to pay any such tax, assessment, charge, levy or claim that is being contested in good faith and by appropriate proceedings if the Company or any subsidiary shall have set aside on its books sufficient reserves, if any,
with respect thereto; 
 (b) Payment of Trade Debt. Pay, and cause each subsidiary to pay, when due, or in
conformity with customary trade terms but not later than ninety (90) days from the due date, all lease obligations, all trade debt, and all other indebtedness incident to the operations of the Company or its subsidiaries, except such as are
being contested in good faith and by proper proceedings if the Company or subsidiary concerned shall have set aside on its books sufficient reserves, if any, with respect thereto; 

(c) Maintenance of Insurance. Maintain, and cause each subsidiary to maintain, insurance with responsible and
reputable insurance companies or associations in such amounts and covering such risks as is customarily carried by companies engaged in similar businesses and owning similar properties in the same general areas in which the Company or such
subsidiary operates; 
 (d) Preservation of Corporate Existence. Preserve and maintain, and, unless the
Company reasonably deems it not to be in its best interests, cause each subsidiary to preserve and maintain, its corporate existence, rights, franchises and privileges in the jurisdiction of its incorporation, and qualify and remain qualified, and
cause each subsidiary to qualify and remain qualified, as a foreign corporation in each jurisdiction in which such qualification is necessary or desirable in view of its business and operations or the ownership or lease of its properties, except
when the failure to be so qualified would not have a material adverse effect on the Company and its subsidiaries taken as a whole; provided that nothing in this Section 4.3(d) shall prohibit the Company or any of its subsidiaries from engaging
in a corporate transaction in connection with the acquisition of another corporation or business entity by the Company or one or more of its wholly owned subsidiaries by merger, consolidation, share exchange, purchase of substantially all the assets
or other reorganization whereby the stockholders of the Company immediately prior to the transaction own in the aggregate more than 50% of the voting power of the Company or other surviving entity after the transaction; 

(e) Intellectual Property. Secure, preserve and maintain, and cause each subsidiary to secure, preserve and
maintain, all licenses and other rights to use patents, processes, licenses, permits, trademarks, trade names, inventions, intellectual property rights or copyrights owned or used by it to the extent necessary to the conduct of its business or the
business of any subsidiary; 

  
 20 

 (f) Compliance with Laws. Comply, and cause each subsidiary to
comply, with the requirements of all applicable laws, rules, regulations and orders of any governmental authority, the noncompliance with which could materially adversely affect its business or financial condition; 

(g) Records and Books of Account. Keep, and cause each subsidiary to keep, adequate records and books of account in
which complete entries will be made in accordance with generally accepted accounting principles consistently applied, reflecting all financial transactions of the Company and any subsidiary, and in which, for each fiscal year, all proper reserves
for depreciation, depletion, returns of merchandise, obsolescence, amortization, taxes, bad debts and other purposes in connection with its business shall be made; 

(h) Maintenance of Properties. Maintain and preserve, and cause each subsidiary to maintain and preserve, all of
its properties and assets necessary for the proper conduct of its business, in good repair, working order and condition, ordinary wear and tear excepted; 
 (i) Regulatory Compliance. Comply, and cause each subsidiary to comply, with all minimum funding requirements applicable to any pension, employee benefit plans, or employee contribution plans that
are subject to the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), or to the Internal Revenue Code of 1986, as amended (the “Code”), and comply, and cause each subsidiary to comply, in all other material
respects with the provisions of ERISA and the Code, and the rules and regulations thereunder, which are applicable to any such plan; provided further that neither the Company nor any subsidiary will permit any event or condition to exist that would
permit any such plan to be terminated under circumstances that would cause any material lien provided for in section 4068 of ERISA to attach to the assets of the Company or any subsidiary; 

(j) Financings. Promptly, fully and in detail, inform the Board of Directors of the Company of any discussions,
offers or contracts relating to possible financings of any nature for the Company, whether initiated by the Company or any other person, except for arrangements with trade creditors in the ordinary course of business; 

(k) Nature of Business. Continue to conduct its business without material change from the nature of the business as
conducted or contemplated as of the date of this Agreement and it will not enter into material transactions not in the ordinary course of business, except as approved by the Board of Directors of the Company, including the unanimous approval of the
directors nominated by the Investors; and 
 (l) D&O Insurance. The Company will maintain a D&O
insurance policy with a recognized, reputable insurance company covering the directors and officers of the Company in amounts customarily carried by similar companies; provided, however, that the minimum coverage shall be at least $1
million and the Company shall increase such coverage prior to an initial public offering of the Company’s stock to at least $10 million in coverage. 

  
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 4.4 Reservation of Common Stock. The Company will at all times reserve and
keep available, solely for issuance and delivery upon the conversion of the Company’s Preferred Stock, all Common Stock issuable from time to time upon such conversion. 
 4.5 Stock Vesting. 
 (a) Unless otherwise approved by the
Board of Directors of the Company or the Compensation Committee of the Board of Directors, all stock options and other stock equivalents issued prior to the date hereof to employees, directors, consultants and other service providers shall retain
their existing vesting terms. 
 (b) Unless otherwise approved by the Board of Directors of the Company or the
Compensation Committee of the Board of Directors, all stock options and other stock equivalents issued after the date hereof to employees, directors, consultants and other service providers shall be subject to vesting as follows: (i) 25% at the
end of the first year following the date of issue, and 2.0833% per month thereafter over the next three (3) years. With respect to any shares of the Company’s capital stock purchased by any such person, the Company’s repurchase
option shall provide that upon such person’s termination of employment or service with the Company, with or without cause, the Company or its assignee (to the extent permissible under applicable securities laws and other laws) shall have the
option to purchase at cost any unvested shares of stock held by such person. 
 4.6 Proprietary Information and Inventions
Agreement. The Company shall require all employees and consultants to execute and deliver a Proprietary Information and Inventions Agreement in substantially the form provided to the Investors. 

4.7 Bonus Plans/Extraordinary Payments. The Company shall not, without the approval of the Series F Director, (i) adopt any
bonus or retention plan for employees of the Company containing terms substantially similar to that certain Retention Bonus Plan adopted by the Board of Directors of the Company on March 2, 2006 or otherwise providing for payment to such
employees of any amounts received by the Company in a Liquidating Event or Deemed Liquidation Event (as defined the Company’s Second Amended and Restated Certificate of Incorporation); or (ii) otherwise provide for the payment of any
extraordinary cash payments to employees of the Company; provided, however, that salary and standard annual or performance bonuses for such employees approved by the Compensation Committee of the Board of Directors or payments of severance or other
obligations pursuant to agreements with senior management entered into prior to August 2, 2006 or other payments made in the ordinary course of business shall not require the approval of the Series F Director. 

4.8 Expiration of Covenants. The covenants set forth in this Section 4 shall expire and be of no further force or effect upon
the effectiveness of a Qualified Public Offering. 

  
 22 

 Section 5. 
 VOTING AGREEMENT 
 5.1 Investor Shares. Each of the Investors agrees
to hold all shares of voting capital stock of the Company (including but not limited to all shares of Common Stock issued upon conversion or exercise (as applicable) of the Investor Securities or other preferred stock of the Company) registered in
their respective names or beneficially owned by them as of the date hereof and any and all other securities of the Company legally or beneficially acquired by each of the Investors after the date hereof subject to, and to vote such shares in
accordance with, the provisions of this Section 5. 
 5.2 Common Shares. Each of the Common Holders agrees to hold
all shares of voting capital stock of the Company registered in their respective names or beneficially owned by them as of the date hereof and any and all other securities of the Company legally or beneficially acquired by them after the date hereof
subject to, and to vote such shares in accordance with, the provisions of this Section 5. 
 5.3 Election of
Directors. Subject to the provisions of Section 5.7, the Board of Directors of the Company will consist of the following persons: (i) James D. Otvos representing the holders of Common Stock; (ii) the Company’s President and
Chief Executive Officer; (iii) Harold S. Lichtin representing the holders of the Company’s Series A Preferred Stock, Series A-1 Preferred Stock, Series B Preferred Stock, Series B-1 Preferred Stock, Series C Preferred Stock and Series C-1
Preferred Stock (collectively, the “Junior Stock”); (iv) two directors to be designated by the holders of a majority of Series D Stock and Series D-1 Stock collectively, who shall initially be Buzz Benson and Richard Y. Lin (the
“Series D Directors”); (v) one director to be designated by Three Arch Capital, L.P., which seat shall initially be vacant (the “Series E Director”); (vi) one director to be designated by Camden Partners Strategic Fund
III, L.P. and Camden Partners Strategic Fund III-A, L.P., who shall initially be Richard M. Johnston (the “Series F Director”) and (vii) two outside directors to be designated by the unanimous vote of the other directors, who shall
initially be Charles A. Sanders and David T. Giddings. Each time the stockholders of the Company meet, or act by written consent in lieu of a meeting, for the purpose of electing the directors to serve on the Company’s Board of Directors, each
Common Holder and each Investor shall vote all shares of the Company’s capital stock owned by such Common Holder or Investor, as the case may be, in order to cause the election of the directors as set forth above. The Investors and Common
Holders shall not vote to remove any director(s) of the Company designated pursuant to this Section 5 unless such removal is requested or consented to by the party(ies) that have the right to designate such director(s) and any vacancy created
by the resignation, removal or death of a director elected pursuant to this Section 5.3, shall be filled by a representative designated as provided above; provided, however, that in the event that such vacancy is caused by the death or
resignation of Otvos or Lichtin, such vacancy shall be filled by a representative of the holders of the Common Stock or the holders of the Junior Stock, respectively, designated by the unanimous vote of the remaining directors other than the Series
D Directors, the Series E Director and the Series F Director, and each Common Holder and Investor shall thereafter vote all shares of the Company’s capital stock owned by such Common Holder or Investor, as the case may be, to elect such
designee. 

  
 23 

 5.4 Binding Effect of Voting Agreement. The voting agreement set forth in this
Section 5 shall be binding upon any transferee of shares of the Company’s stock held by the Investors and Common Holders. Each such transferee shall execute documents assuming the obligations of the transferor under this Section 5
prior to the completion of such transfer. 
 5.5 Legends. Each certificate held by or now issued to the Investors or the
Common Holders, whether now outstanding or subsequently issued, shall be surrendered to the Company for endorsement or be endorsed by the Company prior to its issuance with substantially the following legend (the “Legend”): 

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A VOTING AGREEMENT AMONG THE HOLDER OF THESE SECURITIES AND CERTAIN
OTHER HOLDERS OF THE ISSUER’S SECURITIES. BY ACCEPTING ANY INTEREST IN SUCH SECURITIES, THE PERSON ACCEPTING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL OF THE PROVISIONS OF SUCH AGREEMENT. COPIES OF SUCH VOTING
AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF THE CORPORATION AT THE PRINCIPAL EXECUTIVE OFFICES OF THE CORPORATION.” 
 The Company agrees that, during the term of this Agreement, it will not remove, and will not permit to be removed (upon registration of transfer, reissuance or otherwise), the Legend from any such
certificate and will place or cause to be placed the Legend on any new certificate issued to the Investors or the Common Holders. 
 5.6 Right of First Refusal/Co-Sale Agreement. Each of the Investors that is a party to that certain Second Amended and Restated Right of First Refusal and Co-Sale Agreement, dated as of the date
hereof (as such agreement may be amended from time to time) (the “ROFR Agreement”) agrees to not to amend or waive any provision of the ROFR Agreement unless such amendment or waiver applies to all Investors that are a party to the ROFR
Agreement in the same fashion. 
 5.7 Other Rights. Except as provided by this Agreement or any other agreement entered
into in connection with the issuance of the Series D Stock, the Series E Stock or the Series F Stock, each Common Holder and Investor shall exercise the full rights of a holder of capital stock of the Company with respect to any shares of capital
stock held by such Common Holder and Investor, respectively. 
 5.8 Termination of Voting Agreement. The covenants set
forth in this Section 5 shall terminate upon the earlier of (a) the closing of a registration statement for the sale of the Company’s shares of Common Stock in an underwritten public offering registered under the 1933 Act, or
(b) the date ten years from the date hereof. 

  
 24 

 Section 6. 
 MISCELLANEOUS 
 6.1 Ownership. Each Common Holder represents
and warrants to the Investors that (a) such Common Holder now owns the Common Stock, free and clear of liens or encumbrances, and has not, prior to or on the date of this Agreement, executed or delivered any proxy or entered into any other
voting agreement or similar arrangement other than one which has expired or terminated prior to the date hereof, and (b) such Common Holder has full power and capacity to execute, deliver and perform this Agreement, which has been duly executed
and delivered by, and evidences the valid and binding obligation of, such Common Holder enforceable in accordance with its terms. 
 6.2 Further Action. If and whenever the Common Stock is sold, the Common Holder or the personal representative of the Common Holder shall do all things and execute and deliver all documents
and make all transfers, and cause any transferee of the Common Stock to do all things and execute and deliver all documents, as may be necessary to consummate such sale consistent with this Agreement. 

6.3 Specific Performance. The parties hereto hereby declare that it is impossible to measure in money the damages which
will accrue to a party hereto or to their heirs, personal representatives, or assigns by reason of a failure to perform any of the obligations under this Agreement and agree that the terms of this Agreement shall be specifically enforceable. If any
party hereto or his heirs, personal representatives, or assigns institutes any action or proceeding to specifically enforce the provisions hereof, any person against whom such action or proceeding is brought hereby waives the claim or defense
therein that such party or such personal representative has an adequate remedy at law, and such person shall not offer in any such action or proceeding the claim or defense that such remedy at law exists. 

6.4 Governing Law. This Agreement shall be governed by, and construed and interpreted in accordance with the laws of the State of
Delaware as applied to agreements among Delaware residents made and to be performed entirely within the State of Delaware. THE PARTIES HERETO WAIVE ALL RIGHTS TO TRIAL BY JURY IN ANY ACTION OR PROCEEDING TO ENFORCE OR DEFEND ANY RIGHTS UNDER THIS
AGREEMENT. 
 6.5 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall
inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. The Company shall not permit the transfer of any certificate of the Company’s stock covered hereby or issue a new
certificate representing such shares of the Company’s stock unless and until the person to whom such security is to be transferred shall have executed a written agreement, substantially in the form of this Agreement, or a joinder agreement,
pursuant to which such person becomes a party to this Agreement and agrees to be bound by all the provisions hereof as if such person were an Investor or Common Holder, as applicable. 

6.6 Entire Agreement. This Agreement constitutes the full and entire understanding and agreement among the parties with regard to
the subjects hereof. Nothing in this Agreement, express or implied, is intended to confer upon any party, other than the parties hereto and their successors and assigns, any rights, remedies, obligations or liabilities under or by reason of this
Agreement, except as expressly provided herein. 

  
 25 

 6.7 Severability. Any invalidity, illegality or limitation of the enforceability with
respect to any Holder of any one or more of the provisions of this Agreement, or any part thereof, whether arising by reason of the law of any such person’s domicile or otherwise, shall in no way affect or impair the validity, legality or
enforceability of this Agreement with respect to any other Holder. In case any provision of this Agreement shall be invalid, illegal or unenforceable, it shall to the extent practicable, be modified so as to make it valid, legal and enforceable and
to retain as nearly as practicable the intent of the parties, and the validity, legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

6.8 Amendment and Waiver. Except as otherwise expressly provided herein, any term of this Agreement may be amended or restated and
the observance of any term of this Agreement may be waived (either generally or in a particular instance, either retroactively or prospectively and either for a specified period of time or indefinitely) with the written consent of the Company and
the Investors, or their transferees, holding at least a majority of the shares of Series D Stock, Series D-1 Stock, Series E Stock and Series F Stock (collectively, “Investor Stock”), voting together as a single group (treated as if
converted at the conversion rate then in effect and including, for such purposes shares of Common Stock into which any shares of Investor Stock shall have been converted that are held by an Investor); provided, however, that any amendment,
restatement or waiver to or of: (i) the rights of the holders of the Series D Stock and Series D-1 Stock, which rights are given solely to such holders (including without limitation Sections 4.3, 5.3 and 6.8), shall also require the written
consent of the Investors, or their transferees, holding at least a majority of the shares of Series D Stock and Series D-1 Stock then outstanding (voting together); (ii) the rights of the holders of the Series E Stock, which rights are given
solely to such holders (including without limitation Sections 4.3, 5.3 and 6.8), shall also require the written consent of the Investors, or their transferees, holding at least a majority of the shares of Series E Stock then outstanding, and
(iii) the rights of the holders of the Series F Stock, which rights are given solely to such holders (including without limitation Sections 2.2, 2.11, 2.14, 4.1, 4.3, 5.3 and 6.8), shall also require the written consent of the Investors, or
their transferees, holding at least a majority of the shares of Series F Stock then outstanding; provided further, however, that no such amendment, restatement or waiver shall reduce the aforesaid percentages of Investor Stock
and Common Stock issued upon conversion thereof required for amendment, restatement or waiver of this Agreement or any term thereof without the consent of the holders of all of such Investor Stock and Common Stock; provided, further,
that any amendment to Section 2.15 (or to Section 2 that would affect the rights of the Common Holders under Section 2.15) shall also require the consent of the holders of at least a majority of the shares of Common Stock issued to,
or issuable upon exercise of options held by, the Common Holders. Any amendment, restatement or waiver effected in accordance with this Section 6.8 shall be binding upon each Common Holder, each Investor and each transferee of the securities
held by any Common Holder or Investor (as well as any subsequent transferees). Notwithstanding this Section 6.8, this Agreement may not be amended or terminated and the observance of any term hereunder may not be waived with respect to any
Investor without the 

  
 26 

 
written consent of such Investor unless such amendment, termination or waiver applies to all Investors in the same fashion. Upon the effectuation of each such amendment, restatement or waiver,
the Company shall promptly give written notice thereof to the Investors and Common Holders who have not previously consented thereto in writing. Notwithstanding anything to the contrary in this Section 6.8, the Company shall be entitled to
include additional purchasers of its Series F Stock as parties to this Agreement by having such additional purchasers execute and deliver an additional counterpart signature page to this Agreement, or a joinder agreement, and all such additional
purchasers shall be deemed “Investors” and “Holders” hereunder. 
 6.9 Delays or Omissions. No delay
or omission to exercise any right, power or remedy accruing to the Company, the Investors, or any transferees upon any breach, default or noncompliance of the Investors or any transferee or the Company under this Agreement, shall impair any such
right, power or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any
waiver, permit, consent or approval of any kind or character on the part of the Company or the Investors of any breach, default or noncompliance under this Agreement or any waiver on the Company’s or the Investors’ part of any provisions
or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing and that all remedies, either under this Agreement, by law, or otherwise afforded to the Company and the Investors,
shall be cumulative and not alternative. 
 6.10 Notices, etc. All notices and other communications required or permitted
hereunder shall be in writing and shall be deemed effectively given upon personal delivery or delivery by express courier service or upon confirmed delivery by facsimile, electronic transmission or telecopy, or on the fifth day (or the tenth day if
to a party with an address outside of the United States) following mailing by registered or certified mail, return receipt requested, postage prepaid, addressed: (a) if to the Company, at: 

LipoScience, Inc. 

2500 Sumner Blvd. 

Raleigh, North Carolina 27616 
 Attention: Timothy J. Williams, Esq., General Counsel 
 Phone: (919) 212-1999

 Fax: (919) 212-1954 
 With a copy to: 
 Helga L. Leftwich, Esq. 

Hutchison Law Group PLLC 
 5410 Trinity Road, Suite 400 
 Raleigh, North Carolina 27607 

Phone: (919) 829-9600 
 Fax: (919) 829-9696 
 or at such other address as the Company shall have furnished to the
Investors in writing, and 

  
 27 

 (b) if to the Series F Investors, at the addresses of such Investors specified on
Exhibit C hereto, or at such other addresses as the Investors shall have furnished to the Company in writing; 
 (c)
if to the Series E Investors, at the addresses of such Investors specified on Exhibit B hereto, or at such other addresses as the Investors shall have furnished to the Company in writing; 

(c) if to a Series D Investor, at such address as the Series D Investor shall have furnished to the Company in writing; and 

(d) if to a Common Holder, at such address as the Common Holder shall have furnished to the Company in writing. 

6.11 Titles and Subtitles. The titles of the sections and subsections of this Agreement are for convenience of reference only and
are not to be considered in construing this Agreement. 
 6.12 Additional Shares. In the event that subsequent to
the date of this Agreement any shares or other securities are issued on, or in exchange for, any shares of the Company’s stock covered hereunder by reason of any stock dividend, stock split, combination of shares, reclassification or the like,
such shares or securities shall be subject to the terms and provisions of this Agreement. 
 6.13 Covenants of the
Company. The Company agrees to use its commercially reasonable best efforts to ensure that the rights granted hereunder are effective and that the parties hereto enjoy the benefits thereof. Such actions include, without limitation, the use of
the Company’s commercially reasonable best efforts to cause the nomination and election of the directors as provided above. The Company will not, by any voluntary action, avoid or seek to avoid the observance or performance of any of the terms
to be performed hereunder by the Company, but will at all times in good faith assist in the carrying out of all of the provisions of this Agreement and in the taking of all such actions as may be necessary, appropriate or reasonably requested by the
holders of a majority of the outstanding voting securities held by the parties hereto, assuming conversion of all outstanding securities, in order to protect the rights of the parties hereunder against impairment. 

6.14 No Liability for Election of Recommended Directors. Neither the Company, the Common Holders, the Investors, nor any officer,
director, stockholder, partner, employee or agent of such party, makes any representation or warranty as to the fitness or competence of the nominee of any party hereunder to serve on the Company’s Board of Directors by virtue of such
party’s execution of this Agreement or by the act of such party in voting for such nominee pursuant to this Agreement. 

6.15 Grant of Proxy. Should the provisions of this Agreement be construed to constitute the granting of proxies, such
proxies shall be deemed coupled with an interest and are irrevocable for the term of the relevant provisions of this Agreement. 

  
 28 

 6.16 Manner of Voting. The voting of shares pursuant to this Agreement may be
effected in person, by proxy, by written consent, or in any other manner permitted by applicable law. 
 6.17
Counterparts. This Agreement may be executed in any number of counterparts, each of which, including facsimile copies, shall be deemed an original, but all of which together shall constitute one instrument. 

6.18 Aggregation of Stock. All Investor Securities, Investor Stock or Registrable Securities (including any shares of Common Stock
issued on conversion thereof), as applicable, held or acquired by affiliated entities or persons shall be aggregated for the purpose of determining the availability of any rights under this Agreement. For the purposes of this Section 6.18, an
affiliated entity or person shall be, with respect to any entity or person, any other entity or person directly or indirectly controlling, controlled by, or under common control with such entity or person. 

6.19 Amended and Restatement of Prior Agreement. This Agreement amends, supersedes and replaces the Prior Agreement in its
entirety, and the execution by the Company and the Requisite Investors shall constitute their consent to such amendment and restatement as required under Sections 2.11 and 6.8 of the Prior Agreement. 

[Signature pages follow.] 

  
 29 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	COMPANY:
	
	LIPOSCIENCE, INC.
		
	By:	 	 /s/ Richard O. Brajer

		 	Richard O. Brajer
		 	President and Chief Executive Officer

  
 30 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	CAMDEN PARTNERS STRATEGIC FUND III, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	 /s/ Richard M. Johnston

	Name:	 	Richard M. Johnston
	Title:	 	Managing Member
	
	CAMDEN PARTNERS STRATEGIC FUND III-A, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	 /s/ Richard M. Johnston

	Name:	 	Richard M. Johnston
	Title:	 	Managing Member

  
 31 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	THREE ARCH CAPITAL, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
		 	Richard Lin, Member
	
	TAC ASSOCIATES, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
		 	Richard Lin, Member

  
 32 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	SIGHTLINE HEALTHCARE FUND III, L.P.
		
	By:	 	SightLineHealthcare Management III, L.P.
	Its:	 	General Partner
		
	By:	 	/s/ Maureen Harder
		 	Maureen Harder, Managing Director
	
	SIGHTLINE HEALTHCARE VINTAGE FUND
		
	By:	 	SightLine Vintage Management, LLC
	Its:	 	General Partner
		
	By:	 	/s/ Maureen Harder
		 	Maureen Harder, Managing Director

  
 33 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	A. M. PAPPAS LIFE SCIENCE VENTURES II, L.P.
		
	By:	 	AMP&A Management II, LLC
	Its:	 	General Partner
		
	By:	 	/s/ Ford S. Worthy
		 	Ford S. Worthy, Partner & CFO

  
 34 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	GE CAPITAL EQUITY INVESTMENTS, INC.
		
	By:	 	/s/ Rafael Torres
		 	Rafael Torres, Vice President
	
	EQUITY INVESTMENT TRUST, A DELAWARE BUSINESS TRUST
		
	By:	 	GE Capital Services Equity Corp.,
	Its:	 	Manager
		
	By:	 	/s/ Lorraine Hliboki
		 	Lorraine Hliboki, Sr. Managing Director

  
 35 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	CHANCELLOR V. L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ Illegible
	Name:	 	 
	Title:	 	 
	
	CHANCELLOR V-A, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ Illegible
	Name:	 	 
	Title:	 	 
	
	CITIVENTURE 2000, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ Illegible
	Name:	 	 
	Title:	 	 

  
 36 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	VARIAN, INC.
		
	By:	 	/s/ Garry W. Rogerson
		 	Garry W. Rogerson, President & CEO

  
 37 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	/s/ Jeffrey M. Lipton
	Jeffrey M. Lipton

  
 38 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	THE MARIE BERG TRUST, DTD 12-2-83
		
	By:	 	/s/ Jeremy Berg
	Name:	 	Jeremy Berg
	Title:	 	Trustee

  
 39 

 IN WITNESS WHEREOF, this Amended and Restated Investor Rights Agreement has been duly
executed and delivered by the parties as of the date first above written. 
  

			
	INVESTORS:
	
	/s/ Stephen K. Markham
	Stephen K. Markham

  
 40 

 EXHIBIT A 
 Schedule of Series D Investors 
 Arasaratnam, Thirumurugan 

Armitage, Ian M. 
 The Marie Berg Trust, DTD
12-2-83 
 Davis, Anne G. 
 DiGilio,
Christopher 
 DiGilio, John D. 

DiGilio, Theodore M. and Elaine J. DiGilio 

Doggett, Jane 
 Doggett, Mark P. 

Doggett, Michael S. 
 Drutz, David J. 

Drutz, Jonathan Morris 
 Equity Asset Investment
Trust 
 Fulton, III, William H. and Barbara E. Fulton 
 Harold S. Lichtin Family LP 
 Jeyarajah, Elias J. 

Jeyarajah, Shanthini 
 Jones, Steven C.

 Lawrence & Company Inc. 

Lindsey, Jonathan S. 
 Lorraine, Matthew J.
Lorraine 
 Lorraine, Michael P. Lorraine 
 Lorraine, Peter A. Lorraine 
 Mahalingam, Satkunakumar 

Markham, Stephen K. 
 Mattox, Jr., James D.

 McCutchen, Doyle, Brown & Enersen LLP 
 Mitchell, Jerry E. 
 Mitchell, John F. 
 Mudra, Stephen 
 Murray, John and Coralie Eddy Murray TTEES, U/A/D 5-9-94 As Amended, Creating the
Murray Family Trust 
 Neeb, Robert W. 

Nithianandarajah, Elias 
 Northcreek Capital
Partners, LLC 
 Osgood, Richard H. & Catherine F. Osgood TTEES for the Osgood Family Trust UAD 4/14/2000 

Pacific Rim Life Science No. 2 Investment Partnership 
 Palladin Opportunity Fund LLC 
 Presnell, III, Lacy M. and Sydnor C. Presnell 

Rajendra, Clement 
 Ranjithan, N. A. 

 Ranjithan, Vimala 
 LMWW C/F FBO Robert Rosenson SEP IRA 
 Smith Barney FBO Ronald H. Rosenson IRA Rollover 

Satellite Healthcare 
 SightLine Healthcare Fund
III, L.P. 
 Stanton, Sr., Frank Ronald 

Stone, K. C. 
 TAC Associates, L.P. 

Taylor, John F. and Gail S. Taylor 
 Three Arch
Capital, L.P. 
 Westover Partners 

Wetzel, Ronald and Lucy Wetzel 

 EXHIBIT B 
 Schedule of Series E Investors 
 Three Arch Capital, L.P. 

TAC Associates, L.P. 
 SightLine Healthcare Fund
III, L.P. 
 GE Capital Equity Investments, Inc. 
 Charles A. Sanders 
 A. M. Pappas Life Science Ventures II, L.P. 

Ian M. Armitage 
 Daniel C. Arnold 

Elias J. Jeyarajah 
 Shanthini Jeyarajah

 Robert B. Johnson and Melissa R. Johnson, JT TEN 
 The Frank H. Lamson-Scribner, Jr. Trust Under Deed of Trust Dated October 13, 1982 

Lawrence & Company Inc. 
 James D.
Mattox, Jr. 
 Robert W. Neeb 

Northcreek Capital Partners, LLC 
 Palladin
Opportunity Fund LLC 
 Lacy M. Presnell, III and Sydnor Cozart, JT TEN 
 Satellite Healthcare 
 William A. Schreyer 
 Robert W. Spearman and Patricia H., JT TEN 
 Michael Zapata, III and Lisa Painter, JT TEN

 Qun Zhou and Gong Shen, JT TEN 

Chancellor V, L.P. 
 Chancellor V-A, L.P.

 Citiventure 2000, L.P. 
 Jeffrey M.
Lipton 
 Varian, Inc. 

 EXHIBIT C 
 Schedule of Series F Investors 
 A.M. Pappas Life Science Ventures II, LP 

Camden Partners Strategic Fund III, L.P. 
 Camden
Partners Strategic Fund III-A, L.P. 
 Chancellor V, L.P. 
 Chancellor V-A, L.P. 
 Citiventure 2000, L.P. 

GE Capital Equity Investments, Inc. 
 SightLine
Healthcare Fund III, LP 
 SightLine Healthcare Vintage Fund 
 Three Arch Capital, L.P. 
 TAC Associates, L.P. 

Varian, Inc. 
 Jeffrey M. Lipton 

The Marie Berg Trust 
 Stephen K. Markham

 EXHIBIT D 
 Schedule of Common Holders 
  

					
	 Holder
	  	Shares of Capital Stock Held	 
	 Crawford, Dorothy Ann
	  	 	800	  
		
	 Farkas, Beverly A.
	  	 	15,004	  
		
	 Irrevocable Trust Agmt. Between Richard Anthony Franco, Grantor, and Richard Anthony Franco, Jr., TTEE Dtd. 12-20-01, FBO Alyssa
Marie Franco
	  	 	4,000	  
		
	 Franco, Danielle
	  	 	64,000	  
		
	 Franco, Dianne M.
	  	 	37,124	  
		
	 Franco, Richard A.
	  	 	271,466	  
		
	 Franco, Jr., Richard A. and Kathleen S. Franco
	  	 	64,000	  
		
	 Irrevocable Trust Agmt. Between Richard Anthony Franco, Grantor, and Richard Anthony Franco, Jr., TTEE Dtd. 12-20-01, FBO Richard
Anthony Franco
	  	 	4,000	  
		
	 Harpold, Michael A.
	  	 	14,620	  
		
	 Harpold, Peggy
	  	 	26,666	  
		
	 Harpold, Terry A.
	  	 	15,004	  
		
	 Huddleston, Michelle
	  	 	2,400	  
		
	 Humann, Diane and Greg Humann
	  	 	9,065	  
		
	 Markham, Allyson Rae
	  	 	70,667	  
		
	 Irrevocable Trust Agmt. Between Stephen Keith Markham, Grantor, and Diane Ruth Humann, TTEE Dtd 12-27-01, FBO Ashley Rae
Markham
	  	 	8,320	  
		
	 Irrevocable Trust Agmt. Between Stephen Keith Markham, Grantor, and Diane Ruth Humann, TTEE Dtd 12-27-01, FBO Emily Ann
Markham
	  	 	8,320	  
		
	 Markham, Glen and Stephanie Markham
	  	 	800	  
		
	 Irrevocable Trust Agmt. Between Stephen Keith Markham, Grantor, and Diane Ruth Humann, TTEE Dtd 12-27-01, FBO Jillian Lela
Markham
	  	 	8,320	  

					
	 Holder
	  	Shares of Capital Stock Held	 
	 Irrevocable Trust Agmt. Between Stephen Keith Markham, Grantor, and Diane Ruth Humann, TTEE Dtd 12-27-01, FBO Joshua Hartley
Markham
	  	 	8,320	  
		
	 Markham, Keith and Lela Markham
	  	 	1,760	  
		
	 Markham, Stephen K.
	  	 	108,396	  
		
	 Irrevocable Trust Agmt. Between Stephen Keith Markham, Grantor, and Diane Ruth Humann, TTEE Dtd 12-27-01, FBO Stephen Keith
George Markham
	  	 	8,320	  
		
	 Otvos, Allan G.
	  	 	2,288	  
		
	 Otvos, James D.
	  	 	934,702	  
		
	 Irrevocable Trust Agmt. Between James D. Otvos, Grantor, and Laura D. Hibbert, TTEE Dtd 12/17/01, FBO Jennifer Anne
Otvos
	  	 	169,088	  
		
	 Otvos, Sally S.
	  	 	371,480	  
		
	 Irrevocable Trust Agmt. Between James D. Otvos, Grantor, and Laura D. Hibbert, TTEE Dtd 12/17/01, FBO Sarah Allene
Otvos
	  	 	169,088	  
		
	 Rossi, Sandra S.
	  	 	2,288	  
		
	 Sessions, Nancy
	  	 	160	  
		
	 Stanton, Jr., Frank R.
	  	 	2,400	  
		
	 Stanton, Sr., Frank Ronald
	  	 	95,006	  
		
	 Stanton, Sr., Frank Ronald and Molly Elder Stanton
	  	 	15,882	  
		
	 Stanton, John A.
	  	 	2,400	  
		
	 Turner, Linda
	  	 	2,288	  
		  	 	 	 
	 TOTALS
	  	 	2,518,442	  
		  	 	 	 

 LIPOSCIENCE, INC. 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 THIS FIRST AMENDMENT TO SECOND
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “First Amendment”) is effective as of October 28, 2010 by and among LipoScience, Inc., a Delaware corporation (the “Company”), and the undersigned holders of
at least a majority of the outstanding shares of the Company’s Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and Series F Preferred Stock, voting together as a single group on an as-converted basis
(collectively, the “Investors” and together with the Company, the “Parties”). 
 WHEREAS, the
Parties and certain other individuals and entities are parties to a Second Amended and Restated Investor Rights Agreement, dated August 2, 2006 (the “Investor Rights Agreement”); and 

WHEREAS, pursuant to Section 6.8 of the Investor Rights Agreement, the Parties desire to amend the Investor Rights Agreement in the
manner and to the extent set forth herein. 
 NOW, THEREFORE, the Parties hereby agree as follows: 

1. Defined Terms. Capitalized terms used herein that are not otherwise defined shall have the meaning given to them in the
Investor Rights Agreement. 
 2. Amendment to Section 5.3. Section 5.3(vii) of the Investor Rights Agreement is
deleted in its entirety and replaced with the following: 
 “(vii) three outside directors to be designated
by the vote of at least seventy percent (70%) of the other directors then in office.” 
 3. Effect of First
Amendment. The provisions of the Investor Rights Agreement are amended and modified by the provisions of this First Amendment. If any provisions of the Investor Rights Agreement are different from or inconsistent with any of the provisions of
this First Amendment, the provisions of this First Amendment shall control, and the provisions of the Investor Rights Agreement shall, to the extent of such difference or inconsistency, be amended and modified. 

4. Single Agreement. This First Amendment and the Investor Rights Agreement shall constitute and be construed as a single
agreement. 
 5. Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be
enforceable against the parties actually executing such counterparts, and all of which together shall constitute one instrument. 

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	LIPOSCIENCE, INC.
		
	By:	 	/s/ Richard O. Brajer
		 	Richard O. Brajer
		 	President & Chief Executive Officer

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	THREE ARCH CAPITAL, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
	Name:	 	 
	Title:	 	 
	
	TAC ASSOCIATES, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
	Name:	 	 
	Title:	 	 

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	CAMDEN PARTNERS STRATEGIC FUND III, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	/s/ Richard M. Johnston
	Name:	 	Richard M. Johnston
	Title:	 	Managing Member
	
	CAMDEN PARTNERS STRATEGIC FUND III-A, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	/s/ Richard M. Johnston
	Name:	 	Richard M. Johnston
	Title:	 	Managing Member

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	SIGHTLINE HEALTHCARE FUND III, L.P.
		
	By:	 	SightLineHealthcare Management III, L.P.
	Its:	 	General Partner
		
	By:	 	/s/ Buzz Benson
	Name:	 	 
	Title:	 	 
	
	SIGHTLINE HEALTHCARE VINTAGE FUND
		
	By:	 	SightLineHealthcare Management III, L.P.
	Its:	 	General Partner
		
	By:	 	/s/ Buzz Benson
	Name:	 	 
	Title:	 	 

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	CHANCELLOR V. L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner
	
	CHANCELLOR V-A, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner
	
	CITIVENTURE 2000, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	A. M. PAPPAS LIFE SCIENCE VENTURES II, L.P.
		
	By:	 	AMP&A Management II, LLC
	Its:	 	General Partner
		
	By:	 	/s/ Ford S. Worthy
	Name:	 	Ford S. Worthy
	Title:	 	Partner and CEO

 SEPARATE SIGNATURE PAGE TO 

FIRST AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED OCTOBER 28, 2010

  

			
	GE CAPITAL EQUITY INVESTMENTS, INC.
		
	By:	 	 
	Name:	 	 
	Title:	 	 
	
	 EQUITY INVESTMENT TRUST, A DELAWARE
 BUSINESS TRUST

		
	By:	 	GE Capital Services Equity Corp.,
	Its:	 	Manager
		
	By:	 	 
	Name:	 	 
	Title:	 	 

 LIPOSCIENCE, INC. 

SECOND AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 THIS SECOND AMENDMENT TO SECOND
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Second Amendment”) is effective as of March 11, 2011 by and among LipoScience, Inc., a Delaware corporation (the “Company”), and the undersigned holders of at
least a majority of the outstanding shares of the Company’s Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and Series F Preferred Stock, voting together as a single group on an as-converted basis (collectively,
the “Investors” and together with the Company, the “Parties”). 
 WHEREAS, the Parties and
certain other individuals and entities are parties to a Second Amended and Restated Investor Rights Agreement, dated August 2, 2006, as amended (the “Investor Rights Agreement”); and 

WHEREAS, pursuant to Section 6.8 of the Investor Rights Agreement, the Parties desire to amend the Investor Rights Agreement in the
manner and to the extent set forth herein. 
 NOW, THEREFORE, the Parties hereby agree as follows: 

1. Defined Terms. Capitalized terms used herein that are not otherwise defined shall have the meaning given to them in the
Investor Rights Agreement. 
 2. Amendment to Section 5.3. Section 5.3 of the Investor Rights Agreement is
hereby deleted in its entirety and replaced with the following: 
 “Election of Directors. Subject to
the provisions of Section 5.7, the Board of Directors of the Company will consist of the following persons: (i) the Company’s President and Chief Executive Officer; (ii) Charles A. Sanders representing the holders of the
Company’s Series A Preferred Stock, Series A-1 Preferred Stock, Series B Preferred Stock, Series B-1 Preferred Stock, Series C Preferred Stock and Series C-1 Preferred Stock (collectively, the “Junior Stock”); (iii) two directors
to be designated by the holders of a majority of Series D Stock and Series D-1 Stock collectively, currently designated as Buzz Benson and Roderick A. Young (the “Series D Directors”); (iv) one director to be designated by Three Arch
Capital, L.P., which seat shall initially be vacant (the “Series E Director”); (v) one director to be designated by Camden Partners Strategic Fund III, L.P. and Camden Partners Strategic Fund III-A, L.P., currently designated as
Christopher W. Kersey (the “Series F Director”) and (vi) four outside directors to be designated by the vote of at least seventy percent (70%) of the other directors then in office. Each time the stockholders of the Company meet,
or act by written consent in lieu of a meeting, for the purpose of electing the directors to serve on the Company’s Board of Directors, each Common Holder and each Investor shall vote all shares of the Company’s capital stock owned by such
Common Holder or 

 
Investor, as the case may be, in order to cause the election of the directors as set forth above. The Investors and Common Holders shall not vote to remove any director(s) of the Company
designated pursuant to this Section 5 unless such removal is requested or consented to by the party(ies) that have the right to designate such director(s) and any vacancy created by the resignation, removal or death of a director elected
pursuant to this Section 5.3, shall be filled by a representative designated as provided above.” 
 3. Effect of
Second Amendment. The provisions of the Investor Rights Agreement are amended and modified by the provisions of this Second Amendment. If any provisions of the Investor Rights Agreement are different from or inconsistent with any of the
provisions of this Second Amendment, the provisions of this Second Amendment shall control, and the provisions of the Investor Rights Agreement shall, to the extent of such difference or inconsistency, be amended and modified. 

4. Single Agreement. This Second Amendment and the Investor Rights Agreement shall constitute and be construed as a single
agreement. 
 5. Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be
enforceable against the parties actually executing such counterparts, and all of which together shall constitute one instrument. 

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDED 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	LIPOSCIENCE, INC.
		
	By:	 	/s/ Richard O. Brajer
		 	Richard O. Brajer
		 	President & Chief Executive Officer

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	THREE ARCH CAPITAL, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
	Name:	 	Richard Lin
	Title:	 	Member
	
	TAC ASSOCIATES, L.P.
		
	By:	 	TAC Management L.L.C.
	Its:	 	General Partner
		
	By:	 	/s/ Richard Lin
	Name:	 	Richard Lin
	Title:	 	Member

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	CAMDEN PARTNERS STRATEGIC FUND III, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	/s/ Richard M. Berkeley
	Name:	 	Richard M. Berkeley
	Title:	 	Managing Director
	
	CAMDEN PARTNERS STRATEGIC FUND III-A, L.P.
		
	By:	 	 Camden Partners Strategic III, LLC,
 its General Partner

		
	By:	 	 Camden Partners Strategic Manager, LLC,
 its Managing Member

		
	By:	 	/s/ Richard M. Berkeley
	Name:	 	Richard M. Berkeley
	Title:	 	Managing Director

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	SIGHTLINE HEALTHCARE FUND III, L.P.
		
	By:	 	SightLineHealthcare Management III, L.P.
	Its:	 	General Partner
		
	By:	 	/s/ Buzz Benson
	Name:	 	Buzz Benson
	Title:	 	 Managing Director of SightLine
 Partners, GP of GP

	
	SIGHTLINE HEALTHCARE VINTAGE FUND
		
	By:	 	SightLineVintage Management, LLC
	Its:	 	General Partner
		
	By:	 	/s/ Buzz Benson
	Name:	 	Buzz Benson
	Title:	 	 Managing Director of SightLine
 Partners, GP of GP

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	CHANCELLOR V. L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner
	
	CHANCELLOR V-A, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner
	
	CITIVENTURE 2000, L.P.
	By:	 	IPC Direct Associates, V, LLC,
	Its:	 	General Partner
		
	By:	 	INVESCO Private Capital, Inc.,
	Its:	 	Managing Member
		
	By:	 	/s/ E. Lohrasbpour
	Name:	 	E. Lohrasbpour
	Title:	 	General Partner

 SEPARATE SIGNATURE PAGE TO 

SECOND AMENDMENT TO SECOND AMENDEND 
 AND RESTATED INVESTOR RIGHTS AGREEMENT 
 DATED MARCH 11, 2011

  

			
	A. M. PAPPAS LIFE SCIENCE VENTURES II, L.P.
		
	By:	 	AMP&A Management II, LLC
	Its:	 	General Partner
		
	By:	 	/s/ Ford S. Worthy
	Name:	 	Ford S. Worthy
	Title:	 	Partner and CFOExhibit 10.8

 Exhibit 10.8 
 STANDARD LEASE 
 Parker Business Center - Building 307 and 308 

This Lease is made by and between the Landlord and Tenant named below. 

ARTICLE 1. - BASIC LEASE TERMS 
 For purposes of this Lease, the following terms shall have the meanings set forth below: 
 1.1 Landlord. Parker-Raleigh Development XXX, LLC 
 1.2 Tenant.
Lipomed, Inc., a Delaware corporation 
 1.3 Manager. Parker Lincoln Developers, Inc. 

1.4 Building. The Buildings, (including the Premises) known as 2500 Sumner Boulevard, Raleigh, North Carolina 27616,
located on that tract of land (the “Land”) described on Exhibit A hereto, together with all other buildings, structures, fixtures and other improvements (the “Buildings”) located thereon from time to time, being presently as
depicted on the drawing (the “Site Plan”) attached hereto as Exhibit B. The Building, Buildings and the Land are collectively referred to herein as the “Property.” 

1.5 Premises. The floor space and interior wall and ceiling space of that portion of the Buildings outlined in red or highlighted
on Exhibit C attached hereto, resulting in an aggregate of approximately 85,000 square feet of gross leasable area known as Buildings 307 (39,820 square feet) and 308 (33,180 square feet) and a 12,000 square foot connector (the
“Connector”) between the Buildings all as shown on Exhibit C. Landlord will construct the “Improvements” (as defined in the Addendum) and deliver Building 307 to Tenant first. The Commencement Date for Building 307 is anticipated
to be December 15, 2001. Prior to completion of the Improvements in Building 307, Landlord will begin construction of the Improvements in Building 308 and the Connector. The Commencement Date for the Connector and Building 308 is anticipated to
be July 1, 2002. 
 1.6 Lease Term. 10 years, 6 months and 14 days beginning on the Commencement
Date for Building 307. 
 1.7 Commencement Date. The “Commencement Date” for each Building shall be the earlier
of the date that Tenant takes possession of the Premises or ten (10) days after Landlord notifies Tenant that the Building is, or will be by a date certain, ready for Tenant to take possession. The Commencement Date shall constitute the
commencement of the Lease Term for all purposes, whether or not Tenant has actually taken possession as evidenced by a Certificate of Occupancy. By mutual agreement of the parties, the Commencement Date may be changed. Within thirty (30) days
after the Commencement Date for each Building, Landlord will provide to Tenant a letter acknowledging the Commencement, Rental Commencement (if different) Expiration Dates, and the square footage of the Building which letter will then be attached
hereto as Exhibit D. Notwithstanding anything herein to the contrary, the Lease Term shall extend through and end on the last day of the last month of the Term. If Tenant is permitted access to the Premises prior to the Commencement Date, such early
entry will be subject to all the terms and provisions of this Lease as though the Commencement Date had occurred, unless otherwise agreed to in writing by Landlord. The Rental Commencement for each Building shall be the fifteenth (15 th) day after
the Commencement Date except as provided in the Addendum. 
 1.8 Base Rent. Base Rent is: 

 

													
	Months	  	Per Square Foot	 	  	Annually	 	 	Monthly	 
	 1 through 6 - Building 307
	  	$	11.85	  	  	 	N/A	  	 	$	39,322.25	  
	 Approximately 7 through 12 - Building 308 and the Connector
	  	$	11.85	  	  	 	N/A	  	 	$	83,937.50	  
	 13 through 24
	  	$	12.15	  	  	$	1,032,750.00	  	 	$	86,062.50	  
	 25 through 36
	  	$	12.45	  	  	$	1,058,250.00	  	 	$	88,187.50	  
	 37 through 48
	  	$	12.76	  	  	$	1,084,600.00	  	 	$	90,383.33	  
	 49 through 60
	  	$	13.08	  	  	$	1,111,800.00	  	 	$	92,650.00	  
	 61 through 72
	  	$	13.41	  	  	$	1,139,850.00	  	 	$	94,987.50	  
	 73 through 84
	  	$	13.75	  	  	$	1,168,750.00	  	 	$	97,395.83	  
	 85 through 96
	  	$	14.09	  	  	$	1,197,650.00	  	 	$	99,804.17	  
	 97 through 108
	  	$	14.44	  	  	$	1,227,400.00	  	 	$	102,283.33	  
	 109 through 120
	  	$	14.80	  	  	$	1,258,000.00	  	 	$	104,833.33	  
	 121 through 126 + 14 days
	  	$	15.17	  	  	$	694,870.34 (6 months, 14 days	) 	 	$	107,454.17	  

 1.9 Security
Deposit. Security Deposit is a $1,500,000.00 letter of credit in the form specified in the Addendum, due at execution of the Lease. 
 1.10 Addresses. 
  

							
	Landlord’s Address:	  	 Tenant’s Address: 
	  	Manager’s Address:
		  	UNTIL THE Commencement Date	  	AS OF THE Commencement Date	  	
	Post Office Box 58036	  	3009 New Bern Avenue	  	2500 Sumner Boulevard	  	Post Office Box 58036
	Raleigh, NC 27658	  	Raleigh, NC 27610	  	Raleigh, NC 27616	  	Raleigh, NC 27658
	ATTN: Legal Department	  	ATTN: Richard A. Franco	  	ATTN: Richard A. Franco	  	ATTN: Accounting Department

  
 Page 1 of 12

 Landlord, Tenant and Manager, by written notice to the others may change from time to time the foregoing
addresses, and Landlord, by written notice to Tenant, may notify Tenant from time to time of the appointment of a new Manager and such new Manager’s address. 
 1.11 Permitted Use: laboratory, testing and related assembly, distribution and offices. 
 1.12 Common Areas. Such parking areas, streets, driveways, aisles, sidewalks, curbs, delivery passages, loading areas, lighting facilities, and all other areas situated on or in the Property which
are designated by Landlord, from time to time, for use by all tenants of the Property in common. 
 1.13 Proportionate
Share. The proportion, expressed as a percentage, that the gross leasable area in square feet in the Premises, as determined by Landlord, bears to the total number of constructed gross leasable area in square feet in the Building or Buildings
(measured outside wall to outside wall), as reasonably determined by Landlord, as of the date that the computation is made. The Connector and Building 307 shall be measured upon completion but prior to the Commencement Date. Landlord shall adjust
the computation if additional square footage is added to the Building or Buildings or to the Premises. 
 1.14 Estimated
Initial Common Area Costs Payment (Includes Common Area Maintenance, Taxes and Insurance): 
  

									
	PSF	  	2002 rate to be determined	  	Annual $ TBD	  	Monthly $ TBD	  	

 1.15 Total Rental: 
 (The total of the Base Rent for Year One and the Estimated Initial Common Area Costs Payments for the balance of the calendar year in which the lease commences.) 

 

					
		 	Annual $ TBD	  	Monthly $ TBD

 1.16
Guarantor(s). The guarantor(s) of Tenant’s obligations under this Lease is (are) 
  

			
		 	 N/A

ARTICLE 2. - GRANTING CLAUSE AND RENT PROVISIONS 
 2.1 Grant of Premises. In consideration of the obligation of Tenant to pay the Base Rent and other charges as provided in this Lease and in consideration of the other terms and provisions of this
Lease, Landlord hereby leases the Premises to Tenant during the Lease Term, subject to the terms and provisions of this Lease. 

2.2 Base Rent. Tenant agrees to pay monthly as Base Rent during the term of this Lease the sum of money set forth in
Section 1.8 of this Lease, which amount shall be payable to Landlord at the address shown above or at such other address that Landlord in writing shall notify Tenant. One (1) monthly installment of Base Rent for Building 307 shall be due
and payable on the date of execution of this Lease by Tenant for the first month’s rent and a like monthly installment shall be due and payable on or before the first day of each calendar month succeeding the Commencement Date during the term
of this Lease, without demand, offset or deduction; provided, if the Commencement Date should be a date other than the first day of a calendar month, the monthly rental set forth above shall be prorated to the end of that calendar month, and all
succeeding installments of rent shall be payable on or before the first day of each succeeding calendar month during the term of this Lease. The first month’s Base Rent for Building 308 and the Connector shall be due at the Commencement Date
thereof and thereafter, as set forth above. Tenant shall pay, as “Additional Rent,” all other sums due under this Lease. Base Rent and Additional Rent are sometimes collectively referred to herein as “Rent.” 

2.3 Common Area Costs. As used in this Lease, the term “Common Area Costs” shall mean all expenses of Landlord with
respect to the maintenance, servicing, repairing and operation of the Property, including, but not limited to the following: maintenance, repair, and replacement costs; electricity, fuel, water, sewer, gas and other utility charges; security, window
washing and janitorial services; trash and snow and ice removal; landscaping and pest control; management fees payable to Landlord, Landlord’s affiliates or third parties; wages and benefits payable to employees of Landlord whose duties are
directly connected with the operation and maintenance of the Property; all services, supplies, repairs, replacement or other expenses for maintaining and operating the Property; the cost, including interest, amortized over its useful life, of any
capital improvement made to the Property by Landlord after the date of this Lease which is required under any governmental law or regulation that was not applicable to the Property at the time it was constructed; the cost, including interest,
amortized over its useful life, of installation of any device or other equipment which improves the operating efficiency of any system within the Premises and thereby reduces operating expenses; all other expenses which generally would be regarded
as operating and maintenance expenses which would reasonably be amortized over a period not to exceed five (5) years; all real property taxes and installments of special assessments, including dues and assessments by means of deed restrictions
and/or owner’s association which accrue against the Property during the term of this Lease; governmental levies or charges of any kind or nature assessed or imposed on the Property, whether by state, county, city or any political subdivision
thereof; and all insurance premiums Landlord is required to pay or deems necessary to pay, including public liability insurance, with respect to the Property. The term operating expenses does not include the following: expenses for repairs,
restoration or other work occasioned by fire, wind, the elements or other casualty that are covered by insurance; income and franchise taxes of Landlord; expenses incurred in leasing to or procuring of tenants, leasing commissions, advertising
expenses and expenses for the renovating of space for new tenants; interest or principal payments on any mortgage or other indebtedness of Landlord; compensation paid to any employee of Landlord above the grade of property manager; any depreciation
allowance or expenses; or operating expenses which are the responsibility of Tenant, or any other tenant. Prior to the Commencement Date, and from time to time thereafter, Landlord shall deliver to Tenant its estimate of the Common Area Costs to be
incurred during the then-current calendar year. Landlord may adjust the estimate from time to time during the year to which it relates. Tenant shall have the right to audit Landlord’s Books and Records as set forth in the Addendum. 

2.4 Common Area Costs Payments. Tenant, on the first day of each month during the Lease Term shall pay to Landlord, as Additional
Rent, without offset or deduction, an amount equal to one-twelfth (1/12) of Tenant’s Proportionate Share of the estimated Common Area Costs as calculated by Landlord (prorated for any partial month). The Estimated Initial Common Area Costs
Payment due from Tenant for the balance of the calendar year in which the Lease commences shall be the sum set forth in Section 1.14 above. All sums payable as Additional Rent under the terms of this Section shall be subject to adjustment as
provided in Section 2.5. 
 2.5 Adjustments to Common Area Costs. Within one hundred twenty (120) days following the
end of each calendar year, Landlord shall furnish to Tenant a statement showing the total actual Common Area Costs for the calendar year just expired, the amount of Tenant’s Proportionate Share of the Common Area Costs, and payments made by
Tenant during such calendar year under Section 2.4. If Tenant’s Proportionate Share of the actual Common Area Costs for such calendar year exceeds the aggregate of Tenant’s monthly payments made during the calendar year just expired,
Tenant shall pay to Landlord the deficiency within thirty (30) 

  
 Page 2 of 12

 
days after receipt of said statement. If Tenant’s payments exceed Tenant’s Proportionate Share of the actual Common Area Costs as shown on such statement, Tenant shall be entitled to
offset the excess against payments thereafter becoming due as Tenant’s Proportionate Share of Common Area Costs. No portion of the Common Area Costs paid by Tenant under this Article 2 shall be credited against Base Rent or any other rental
obligations hereunder. If such excess occurs during the last year of the Lease Term, Landlord shall be obligated to pay any such excess to Tenant within ninety (90) days after expiration of the Lease. This obligation survives termination of
Lease. Common Area Costs (excluding Taxes and Insurance) shall not increase by more than ten percent (10%) per square foot, per year. 
 2.6 Late Payment. Other remedies for nonpayment of Rent notwithstanding, if any payment of Base Rent or Additional Rent is not received by Landlord on or before the fifth (5th) business day of
the month for which the Rent is due, or if any other payment hereunder due Landlord by Tenant is not received by Landlord on or before the fifth (5th) business day of the month next following the month in which Tenant was invoiced, Tenant shall
also pay (a) a late payment charge of five percent (5%), but not less than $100.00, of such past due amount and (b) interest of eighteen percent (18%) per annum or the maximum then allowed by applicable law, whichever is less, on the
remaining unpaid balance, retroactive to the date originally due until paid. Notwithstanding the foregoing, Landlord shall not invoke its rights to late payment fees unless Tenant is late in payment on more than one (1) occasion per year in
each Lease year and provided such payment is made by the fifteenth (15 th) of that month. 
 2.7 Increase in Insurance
Premiums. If an increase in any insurance premiums paid by Landlord for the Property is caused by Tenant’s use of the Premises, or if Tenant vacated the Premises and caused an increase in such premiums, then Tenant shall pay as Additional
Rent the amount of such increase to Landlord. Tenant agrees to pay any amounts due under this Section within ten (10) days following receipt of the invoice showing the Additional Rent due. Tenant shall be given written notice of the increase in
premiums and a right to cure the cause of such increase prior to being obligated to pay such additional premiums, if possible. 

2.8 Security Deposit. This provision shall only apply in the event that Tenant substitutes a cash deposit in accordance with
Paragraph 4 of the Addendum. The Security Deposit set forth in Section 1.9 (if any) shall be held by Landlord for the performance of Tenant’s covenants and obligations under this Lease, it being expressly understood that the Security
Deposit shall not be considered an advance payment of Rent or a measure of Landlord’s damage in case of default hereunder by Tenant, and shall be held by Landlord without payment of any interest thereon. Upon the occurrence of any event of
default by Tenant under this Lease, Landlord may, from time to time, without prejudice to any other remedy, use the Security Deposit to the extent necessary to make good any arrears of Rent, or to repair any damage or injury, or pay any expense or
liability incurred by Landlord as a result of the event of default or breach of covenant, and any remaining balance of the Security Deposit shall be returned by Landlord to Tenant upon the termination of this Lease. If any portion of the Security
Deposit is so used or applied, Tenant shall upon ten (10) days written notice from Landlord, deposit with Landlord by cash or cashier’s check an amount sufficient to restore the Security Deposit to its original amount. The Security Deposit
may be assigned and transferred by Landlord to the successor in interest of Landlord and, upon acknowledgment by such successor of receipt of such security and its assumption of the obligation to account to Tenant for such security in accordance
with the terms of this Lease, Landlord shall thereby be discharged of any further obligation relating thereto. 
 2.9 Notice
to Vacate. (SEE ADDENDUM.) 
 2.10 Holding Over. If Tenant does not vacate the Premises upon the expiration or
earlier termination of this Lease, Tenant shall be a tenant at sufferance for the holdover period and all of the terms and provisions of this Lease shall be applicable during that period, except that Tenant shall pay Landlord (in addition to
Additional Rent payable under Section 2.3 and any other sums payable under this Lease) as Base Rent for the period of such holdover an amount equal to one and one-half times the Base Rent which would have been payable by Tenant had the holdover
period been a part of the original term of this Lease (without waiver of Landlord’s right to recover damages as permitted by law). Upon the expiration or earlier termination of this Lease, Tenant agrees to vacate and deliver the Premises, and
all keys thereto, to Landlord upon delivery to Tenant of notice from Landlord to vacate. The rental payable during the holdover period shall be payable to Landlord on demand. No holding over by Tenant, whether with or without the consent of Landlord
shall operate to extend the term of this Lease. If Tenant holds over without Landlord’s consent, Tenant shall indemnify Landlord against all claims made by any tenant or prospective tenant against Landlord resulting from delay by Landlord in
delivering possession of the Premises to such other tenant or prospective tenant. 
 
 ARTICLE 3. - OCCUPANCY, USE AND OPERATIONS 
 3.1 Use and Operation of
Tenant’s Business. Tenant warrants and represents to Landlord that the Premises shall be used and occupied only for the purpose as set forth in Section 1.11. Tenant shall occupy the Premises, conduct its business and control its
agents, employees, invitees and visitors in such a manner as is lawful, reputable and will not create a nuisance to other tenants in the Property. Tenant shall at all times operate its business in a first class manner. Tenant shall not conduct any
auction or fire or bankruptcy sale in the Premises. Tenant shall not solicit business, distribute handbills or display merchandise within the Common Areas, or take any action, which would interfere with the rights of other persons to use the Common
Areas. Tenant shall not permit any operation which emits any odor or matter which intrudes into other portions of the Property, use any apparatus or machine which makes undue noise or causes vibration in any portion of the Property or otherwise
interfere with, annoy or disturb any other tenant in its normal business operations or Landlord in its management of the Property. Tenant shall neither permit any waste on the Premises nor allow the Premises to be used in any way that would in the
opinion of Landlord, be extra hazardous on account of fire or which would in any way increase or render void the fire insurance on the Property. 
 3.2 Signs. Tenant shall be responsible for the installation of a sign within thirty (30) days of occupancy in accordance with the sign criteria attached hereto as Exhibit G. No other sign of
any type or description shall be erected, placed or painted in or about the Premises or the Property without Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned, or delayed and Landlord reserves the
right to remove, at Tenant’s expense, all signs other than signs approved in writing by Landlord under this Section 3.2, without notice to Tenant and without liability to Tenant for any damages sustained by Tenant as a result thereof.
Tenant shall be liable to Landlord for any cost or expense incurred by Landlord in removing such sign and for any damage caused by the removal of such sign unless caused by Landlord’s negligence in the removal. Landlord reserves the right, in
Landlord’s discretion, to permit a sign or signs which deviate from the Landlord’s then-established sign criteria, and such permission by Landlord to any tenant or tenants shall not give rise to any rights in any other tenants to object
thereto or to require Landlord to permit such other tenant to deviate from the criteria. Nothing contained herein shall limit Landlord’s right to modify or amend such criteria from time to time. 

3.3 Compliance with Laws, Rules and Regulations. 
 (a) Landlord represents that the Premises will comply with all applicable laws, regulations and codes at the Commencement Date. Thereafter, Tenant, at Tenant’s sole cost and expense, shall comply
with all laws, ordinances, orders, rules and regulations of state, federal, municipal or other agencies or bodies having jurisdiction over the use, condition or occupancy of the Premises. Tenant shall procure at its own expense all permits and
licenses required for the transaction of its business in the Premises. 

  
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 (b) The “Americans with Disabilities Act of 1990” (the “ADA”) is a
federal law that prohibits discrimination on the basis of disability. The requirements of this act vary with the type of business the Tenant is engaged in and the number of employees the Tenant has both at this, and other locations. The Landlord is
not qualified to determine which provisions of the ADA apply to Tenant. Therefore, the Tenant shall determine if the Premises complies with the accessibility guidelines under ADA and advise the Landlord if any physical modifications to this Premises
are required to meet the Tenants needs under this law, or any other law, code or regulations. Modifications requested by Tenant to the Premises shall be made by the Landlord, and the Tenant shall pay Landlord the full cost of the modifications
requested. The Tenant shall indemnify and hold harmless the Landlord and its agents and employees from and against all claims, damages, losses and expenses, including but not limited to reasonable Attorney’s fees, arising out of or resulting
from the Tenants compliance or failure to comply with the ADA or other laws, codes or regulations. Tenant shall not be responsible for ADA compliance in the Common Areas or the exterior of the Building unless required in connection with
Tenant’s use of the Premises or resulting from Tenant’s seeking a building permit. 
 (c) Tenant will comply with the
rules and regulations of the Property adopted by Landlord attached hereto as Exhibit E. If Tenant is not complying with such rules and regulations, or if Tenant is in any way not complying with this Article 3, then, notwithstanding anything to the
contrary contained herein, Landlord may, at its election, enter the Premises without liability therefor and fulfill Tenant’s obligations. Tenant shall reimburse Landlord on demand, as Additional Rent, for any expenses, which Landlord may incur
in effecting compliance with Tenant’s obligations, and agrees that Landlord shall not be liable for any damages resulting to Tenant from such action except due to Landlord’s negligence or willful misconduct. Landlord shall have the right
at all times to change and amend the rules and regulations in any reasonable manner as it may deem advisable for the safety, care, cleanliness, preservation of good order and operation or use of the Property or the Premises. All changes and
amendments to the rules and regulations of the Property will be forwarded by Landlord to Tenant in writing and shall thereafter be carried out and observed by Tenant. 
 3.4 Warranty of Possession. Landlord and Tenant each warrants that it has the right and authority to execute this Lease, and Landlord warrants to Tenant, that upon payment of the required rents by
Tenant and subject to the terms, conditions, covenants and agreements contained in this Lease, Tenant shall have possession of the Premises during the full term of this Lease, as well as any extension or renewal thereof, without hindrance from
Landlord or any person or persons lawfully claiming the Premises by, through or under Landlord (but not otherwise); subject, however, to all mortgages, deeds of trust, leases and agreements to which this Lease is subordinate and to all laws,
ordinances, orders, rules and regulations of any governmental authority. Landlord shall not be responsible for the acts or omissions of any other lessee or third party that may interfere with Tenant’s use and enjoyment of the Premises but shall
make reasonable efforts (as determined by Landlord) to correct the problem. 
 3.5 Inspection. With reasonable prior
notice and subject to accompaniment by Tenant, except in the event of an emergency, Landlord or its authorized agents shall at any and all reasonable times have the right to enter the Premises to inspect the same, to supply janitorial service or any
other service to be provided by Landlord, to show the Premises to prospective mortgagees, purchasers or prospective tenants (within the last six (6) months of the Lease Term), and to alter, improve or repair the Premises or any other portion of
the Property provided that such entry does not unreasonably interfere with Tenant’s use or occupancy of the Premises. Tenant hereby waives any claim for abatement or reduction of rent, or for any damages for injury, or inconvenience to, or
interference with, Tenant’s business, for any loss or occupancy or use of the Premises, and for any other loss occasioned thereby unless such loss was caused by the negligence or willful misconduct of Landlord. Landlord shall have the right at
all times to enter the Premises by any means in the event of an emergency without liability therefor. 
 3.6 Personal
Property Taxes. Tenant shall be liable for all taxes levied against leasehold improvements, merchandise, personal property, trade fixtures and all other taxable property located in the Premises. If any such taxes for which Tenant is liable are
levied against Landlord or Landlord’s property and if Landlord elects to pay the same or if the assessed value of Landlord’s property is increased by inclusion of personal property and trade fixtures placed by Tenant in the Premises and
Landlord elects to pay the taxes based on such increase, Tenant shall pay to Landlord, upon demand, that part of such taxes for which the Tenant is primarily liable pursuant to the terms of this Section. Tenant shall pay when due any and all taxes
related to Tenant’s use and operation of its business in the Premises. 
 3.7 Garbage. All garbage and refuse shall
be kept in an area designated by Landlord and in the kind of container specified by Landlord and shall be placed outside of the Premises daily, prepared for collection in the manner and at the times and places specified by Landlord. If Landlord
provides or designates a service for collection of refuse and garbage, Tenant shall use it, at Tenant’s expense, provided the cost thereof is competitive with any identical service available to Tenant. 

ARTICLE 4. - UTILITIES AND SERVICE 
 4.1 Utility Services. Landlord shall provide or cause to be provided the mains, conduits and other facilities necessary to supply water, gas, electricity, telephone service and sewage service to
the Premises. Tenant shall, however, be responsible, at its expense, to make provisions for connecting or hooking up to such utilities, directly with the appropriate utility company furnishing same. 

4.2 Tenant Responsible for Charges. Tenant shall promptly pay all charges and deposits for electricity, water, gas, telephone
service and sewage service and other utilities furnished to the Premises. Landlord may, if it so elects, furnish one or more utility services to Tenant, and in such event, Tenant shall purchase the use of such services as are tendered by Landlord,
and shall pay on demand the rates established therefor by Landlord which shall not exceed the rate which would be charged for the same services if furnished to Tenant directly by the local public utility furnishing the same to the public at large
and including any discounts or credits obtained by Landlord. Landlord may at any time discontinue furnishing any such service without obligation to Tenant other than to connect the Premises to the public utility, if any, furnishing such service.

 4.3 Landlord’s Services. Landlord shall provide routine maintenance, painting and electrical lighting service for
all Common Areas and special service areas of the Property in the manner and to the extent deemed by Landlord to be standard in the Raleigh, North Carolina market. Landlord may, in its sole discretion, provide additional services not enumerated
herein. 
 4.4 No Liability. Landlord shall not be liable for any interruption whatsoever in utility services not
furnished by it, nor for interruption in utility service furnished by it which are due to fire, accident, strikes, acts of God, riot, civil commotion, terrorist act, national emergency, shortage of labor or materials or other causes beyond the
control of Landlord or in order to make alterations, repairs or improvements unless such interruption was because of the negligence or willful misconduct of Landlord. Moreover, Landlord shall not be liable for any interruption of such utility
services, which continues during any reasonable period necessary to restore such service upon the occurrence of any of the foregoing conditions unless due to Landlord’s negligence or willful misconduct. Failure by Landlord to any extent to
provide any services of Landlord specified herein or any other services not specified, or any cessation thereof, 

  
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 shall not render Landlord liable in any respect for damages to either person or property, be construed as an
eviction of Tenant, or an abatement of rent or relieve Tenant from fulfillment of any covenant in this Lease unless such interruption was because of the negligence or willful misconduct of Landlord. If any of the equipment or machinery necessary or
useful for provision of any utility services, and for which Landlord is responsible, breaks down, or for any cause ceases to function properly, shall use reasonable diligence to repair the same promptly, but Tenant shall have no claim for rebate of
rent or damages on account of any interruption in service occasioned from the repairs unless such failure to function was because of the negligence or willful misconduct of Landlord. 

4.5 Theft or Burglary. Unless due to the negligence or willful misconduct of Landlord, Landlord shall not be liable to Tenant for
losses to Tenant’s property or personal injury caused by criminal acts or entry by unauthorized persons into the Premises or the Property. 
 ARTICLE 5. - REPAIRS AND MAINTENANCE 
 5.1 Landlord Repairs. Landlord shall
not be required to make any improvements, replacements or repairs of any kind or character to the Premises during the Term of this Lease except as are set forth in this Section or the Addendum. Landlord shall maintain only the roof, foundation,
parking and Common Areas, and the structural soundness of the Buildings. Landlord’s cost of maintaining and repairing the items set forth in this Section are subject to the additional rent provisions in Section 2.3 and 2.4. Landlord shall
not be liable to Tenant, except as expressly provided in this Lease, for any damage or inconvenience, and Tenant shall not be entitled to any damages nor to any abatement or reduction of rent by reason of any repairs, alterations or additions made
by Landlord under this Lease unless caused by Landlord’s negligence or willful misconduct. 
 5.2 Tenant Repairs.
Tenant shall maintain, at its sole and direct cost, the Premises in a first-class condition (except for those items listed under Section 5.1). Without limiting the generality of the foregoing, Tenant shall maintain and keep in good repair
except for normal wear and tear (including replacement when necessary): 
 (a) the interior of the Premises, including walls,
floors and ceilings; 
 (b) all windows and doors, including frames, glass, molding and hardware; 

(c) all wires and plumbing within the Premises which serve the Premises (as distinguished from those serving the Building generally);

 (d) all signs, air conditioning and heating equipment (see attached Rules and Regulations for service requirements),
mechanical doors and other mechanical equipment situated on or in the Premises or serving the Premises (as distinguished from those serving the Building generally); and 
 (e) those utility facilities that are not maintained by Landlord hereunder. Tenant shall further make all other repairs to the Premises made necessary by Tenant’s failure to comply with its
obligations under this Section. All fixtures installed by Tenant shall be new or shall have been completely and recently reconditioned. 
 On
the Commencement Date, Landlord shall assign to Tenant the warranty covering the new HVAC unit and any other warranties on any portions or components of the Premises, which Tenant is required to maintain or repair under this Lease. 

5.3 Request for Repairs. All requests for repairs or maintenance to Landlord pursuant to Section 5.1 of this Lease must be
made in writing to Landlord at the address in Section 1. except, in an emergency situation, a telephone call shall be acceptable with a written follow-up. All repairs must be completed within a reasonable period of time. 

5.4 Tenant Damages. Tenant shall not allow any damage to be committed on any portion of the Premises or Property, and at the
termination of this Lease, by lapse of time or otherwise, Tenant shall deliver the Premises to Landlord in as good condition as existed at the Commencement Date of this Lease, ordinary wear and tear, and loss by insured casualty excepted. The cost
and expense of any repairs necessary to restore the condition of the Premises shall be borne by Tenant. 
 

ARTICLE 6. - ALTERATIONS AND IMPROVEMENTS 
 6.1 Construction. If any construction of tenant improvements is necessary for the initial occupancy of the Premises, such construction shall be accomplished and the cost of such construction shall
be borne by Landlord and/or Tenant in accordance with Exhibit F and/or the Addendum (if any) attached hereto. Except as expressly provided in this Lease, Tenant acknowledges and agrees that Landlord has not undertaken to perform any modification,
alteration or improvements to the Premises, and Tenant further waives any defects in the Premises and acknowledges and accepts (1) the Premises as suitable for the purpose for which they are leased and (2) the Property and every part and
appurtenance thereof as being in good and satisfactory condition subject to a “Punch List” to be prepared and agreed upon by Landlord and Tenant at occupancy. If any improvements, modifications or alterations, beyond those specified on
Exhibit F or the Addendum, are required for Tenant’s initial occupancy of the Premises, due solely to Tenant’s use of the Premises, by any governmental or municipal body or agency or are required by any law, rule, regulation, ordinance,
code or order, Tenant shall be solely responsible for all associated costs. After the Commencement Date, if any improvements, modifications or alterations are required by any governmental or municipal body or agency or due to any law, rule,
regulation, code, ordinance or order, as a result of Tenant’s use of the Premises, Tenant shall be solely responsible for all associated costs. Upon the request of Landlord, Tenant shall deliver to Landlord a completed Acceptance of Premises
Memorandum in Landlord’s prescribed form. If Landlord pays for the cost of construction of any Tenant improvements and the cost is amortized over the Lease Term and included in the Base Rent, Landlord shall be entitled to collect the unpaid
balance in the event that the Lease is terminated or Tenant’s right to possession of the Premises is terminated due to a default by Tenant. 
 6.2 Tenant Improvements. Tenant shall not make or allow to be made any alterations, physical additions or improvements in or to the Premises without first obtaining the written consent of Landlord,
which consent shall not be unreasonably withheld, conditioned, or delayed. Any alterations, physical additions or improvements to the Premises made by or installed by either party hereto shall remain upon and be surrendered with the Premises and
become the property of Landlord upon the expiration or earlier termination of this Lease without credit to Tenant; provided, however, Landlord, at its option, may require Tenant to remove any physical improvements or additions and/or repair any
alterations in order to restore the Premises to the condition existing at the time Tenant took possession, all costs of removal and/or alterations to be borne by Tenant. Notwithstanding the foregoing, Tenant may request in writing that Landlord make
a determination at the time of consent as to whether the Tenant improvements will have to be removed at the end of the Lease Term. This clause shall not apply to moveable equipment, furniture or moveable trade fixtures owned by Tenant, which may be
removed by Tenant at the end of the term of this Lease. Tenant shall have no authority or power, express or 

  
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 implied, to create or cause any mechanic’s or materialmen’s lien, charge or encumbrance of any
kind against the Premises, the Property or any portion thereof. Tenant shall promptly cause any such liens that have arisen by reason of any work claimed to have been undertaken by or through Tenant to be released by payment, bonding or otherwise
within thirty (30) days after request by Landlord, and shall indemnify Landlord against losses arising out of any such claim (including, without limitation, reasonable legal fees and court costs). 

6.3 Common and Service Area Alterations. Landlord shall have the right to decorate and to make repairs, alterations, additions,
changes or improvements, whether structural or otherwise, in, about or on the exterior of the Property, or any part thereof exclusive of the Premises, and to change, alter, relocate, remove or replace service areas and/or Common Areas, and to
otherwise alter or modify the Property exclusive of the Premises, and for such purposes, to take such measures for safety or for the expediting of such work as may be required, in Landlord’s judgment, all without affecting any of Tenant’s
obligations hereunder, provided such changes do not unreasonably interfere with Tenant’s use and enjoyment of the Premises. 

ARTICLE 7. - CASUALTY AND INSURANCE 
 7.1 Substantial Destruction. If in the reasonable determination of Landlord the Premises should be totally destroyed by fire or other casualty, or if in the reasonable determination of Landlord the
Premises should be damaged so that rebuilding cannot reasonably be completed substantially within one hundred and eighty (180) working days after Landlord’s receipt of written notification by Tenant of the destruction, or if the Premises
are damaged or destroyed by casualty not covered by the standard broad form of fire and extended coverage insurance then in common use in the State of North Carolina, then, at Landlord’s and Tenant’s option, this Lease shall terminate and,
in such case, the rent shall be abated for the unexpired portion of the Lease, effective as of the date of the written notification. 
 7.2 Partial Destruction. If following damage or destruction to the Premises by fire or other casualty, this Lease is not terminated pursuant to Section 7.1 hereof, this Lease shall not
terminate, and Landlord shall proceed, to the extent of insurance proceeds actually received by Landlord after the exercise by any mortgagee of the Property of an option to apply proceeds against Landlord’s debt to such mortgagee, with
reasonable diligence to rebuild or repair the Building or other improvements to substantially the same conditions in which they existed as of the Commencement Date, normal wear and tear excepted. If the Premises are to be rebuilt or repaired and are
untenantable in whole or in part following the damage, and the damage or destruction was not caused or contributed to by act or negligence of Tenant, its agents, employees, invitees or those for whom Tenant is responsible, the Base Rent payable
under this Lease during the period for which the Premises are untenantable until the Premises are returned to the condition that existed as of the Commencement Date shall be reduced to an amount determined by multiplying the Base Rent that would
otherwise be payable but for this provision by the ratio that the portion of the Premises not rendered untenantable bears to the total net rentable area of the Premises prior to the casualty. Landlord’s obligation to rebuild or restore under
this Section shall be limited to restoring the Premises to substantially the condition in which the same existed prior to the casualty including the Improvements as defined in the Addendum, exclusive of improvements constructed by Tenant , and
Tenant shall, promptly after the completion of such work by Landlord, proceed with reasonable diligence and at Tenant’s sole cost and expense to restore those improvements for which Tenant is responsible to substantially the condition in which
the same existed prior to the casualty and to otherwise make the Premises suitable for Tenant’s use. If Landlord fails to substantially complete the necessary repairs or rebuilding within one hundred and eighty (180) working days from the
date of Landlord’s receipt of written notification by Tenant of the destruction, Tenant may at its own option terminate this Lease by delivering written notice of termination to Landlord, whereupon all rights and obligations under this Lease
shall cease to exist. 
 7.3 Property Insurance. Landlord shall at all times during the term of this Lease insure the
Property against all risk of direct physical loss in an amount and with such deductibles as Landlord considers reasonably appropriate; provided, Landlord shall not be obligated in any way or manner to insure any personal property (including, but not
limited to, any furniture, machinery, goods or supplies) of Tenant upon or within the Premises, any fixtures installed or paid for by Tenant upon or within the Premises, or any improvements which Tenant may construct on the Premises. Tenant shall
have no right in or claim to the proceeds of any policy of insurance maintained by Landlord even if the cost of such insurance is borne by Tenant as set forth in Article 2. Landlord shall have the right to self-insure against the above-described
risk provided Landlord gives advance written notice to Tenant. Tenant at all times during the term of this Lease shall, at its own expense, keep in full force and effect insurance against fire and such other risks as are from time to time included
in standard all-risk insurance policy (including coverage against vandalism, theft, burglary, and malicious mischief) for the Premises and the full replacement cost of Tenant’s trade fixtures, furniture, supplies and all items of personal
property of Tenant located on or within the Premises. Tenant’s policy shall also include business interruption/extra expense coverage in sufficient amounts. Landlord shall be a named insured on said policy. 

7.4 Waiver of Subrogation. Anything in this Lease to the contrary notwithstanding, Landlord and Tenant hereby waive and release
each other of and from any and all right of recovery, claim, action or cause of action, against each other, their agents, officers and employees, for any loss or damage that may occur to the Premises, improvements to the Property, or personal
property within the Property, by reason of fire or the elements, regardless of cause or origin, including negligence of Landlord or Tenant and their agents, officers and employees. Landlord and Tenant agree immediately to give their respective
insurance companies which have issued policies of insurance covering all risk of direct physical loss, written notice of the terms of the mutual waivers contained in this Section, and to have the insurance policies properly endorsed, if necessary,
to prevent the invalidation of the insurance coverages by reason of the mutual waivers. 
 7.5 Hold Harmless. Unless and
to the extent caused by Landlord’s negligence or willful misconduct, Landlord shall not be liable to Tenant or to Tenant’s customers, employees, agents, guests or invitees, or to any other person whomever, for any injury to persons or
damage to property on or about the Premises, including but not limited to, consequential damage, (1) caused by any act or omission of Tenant, its employees, subtenants, licensees and concessionaires or of any other person entering the Property
or the Premises by express or implied invitation of Tenant, or (2) arising out of the use of the Premises or the Property by Tenant, its employees, subtenants, licensees, concessionaires or invitees, or (3) arising out of any breach or
default by Tenant in the performance of its obligations hereunder, or (4) caused by the improvements located in the Premises becoming out of repair or by defect in or failure of equipment, pipes, or wiring, or by broken glass, or by the backing
up of drains, or by gas, water, steam, electricity or oil leaking, escaping or flowing into the Premises or Property, or (5) arising out of the failure or cessation of any service provided by Landlord (including security service and devices),
and Tenant hereby agrees to indemnify Landlord and hold Landlord harmless from any liability, loss, expense or claim (including, but not limited to reasonable attorneys’ fees) arising out of such damage or injury. Nor shall Landlord be liable
to Tenant for any loss or damage that may be occasioned by or through the acts or omissions of other tenants of the Property or of any other persons whomsoever, excepting only duly authorized employees and agents of Landlord acting within the scope
of their authority. Further, Tenant specifically agrees to be responsible for and indemnify and hold Landlord harmless from any and all damages or expenses of whatever kind arising out of or caused by a burglary, theft, vandalism, malicious mischief
or other illegal acts performed in, at or from the Premises unless caused by Landlord’s negligence or willful misconduct. Landlord hereby agrees to 

  
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 indemnify Tenant and hold Tenant harmless from any liability, loss, expense or claim (including, but not
limited to reasonable attorneys’ fees) arising out of the negligence or willful misconduct of Landlord. 
 7.6
Insurance. Tenant at all times during the Lease shall, at its own expense, keep in full force and effect the following policies: 
 (a) commercial general liability insurance with “personal injury” coverage and contractual liability coverage, with minimum combined bodily injury and property damage limit of $1,000,000 per
occurrence per location subject to no deductible. 
 (b) Affording coverage under the Workers Compensation laws of the State of
North Carolina and Employers Liability coverage subject to a limit of no less than $100,000 each employee, $100,000 each accident, $500,000 policy limit. 
 (c) Tenant shall maintain umbrella liability insurance at not less than a $1,000,000 limit providing excess coverage over all limits and coverages noted in 7.6.a and 7.6.b above. 

(d) At all times when a “boiler,” as that term is defined for the purposes of boiler insurance, is located within the Premises,
Tenant shall carry, at its expense, boiler insurance with policy limits of not less than One Hundred Thousand Dollars ($100,000.00) insuring both Landlord and Tenant against loss or liability caused by the operation or malfunction of such boiler.

 These policies shall be written on an occurrence basis. All policies noted above shall be written with insurance companies
licensed to do business in the State of North Carolina and rated no lower than A: 10 in the most current edition of A.M. Best’s Casualty Key Rating Guide. All policies shall be endorsed to provide that in the event of cancellation, non-renewal
or material modification, Landlord shall receive thirty (30) days written notice thereof. Landlord shall be an additional insured on the policies . Definition of additional insured shall include all partners, officers, directors, employees,
agents and representatives of the named entities including its managing agent. Further, coverage for additional insured shall apply on a primary basis irrespective of any other insurance, whether collectible or not. All insurance policies or duly
executed certificates for the same required to be carried by Tenant under this Lease, together with satisfactory evidence of the payment of the premium thereof, shall be deposited with Landlord on the date Tenant first occupies the Premises and upon
renewals of such policies not less than fifteen (15) days prior to the expiration of the term of such coverage. All insurance required to be carried by Tenant under this Lease shall be in form and content, and written by insurers acceptable to
Landlord, in its reasonable discretion. If Tenant shall fail to comply with any of the requirements contained relating to insurance, Landlord may obtain such insurance and Tenant shall pay to Landlord, on demand as additional rent hereunder, the
premium cost thereof. 
 7.8 Hazardous Materials. Throughout the term of this Lease, Tenant shall prevent the presence,
use, generation, release, discharge, storage, disposal, or transportation of any Hazardous Materials (as hereinafter defined) on, under, in, above, to, or from the Premises other than in strict compliance with all applicable federal, state, and
local laws, rules, regulations and orders. For purposes of this provision, the term “Hazardous Materials” shall mean and refer to any wastes, materials, or other substances of any kind or character that are or become regulated as hazardous
or toxic, or which require special handling or treatment, under any applicable local, state or federal law, rule, regulation or order. In addition, the term “Hazardous Materials” includes (i) oil of any kind and in any form,
including, but specifically not limited to, petroleum, crude oil, diesel oil, fuel oil, gasoline, lubrication oil, oil refuse, oil mixed with other waste, oil sludge, petroleum related products or by-products, and all other liquid hydrocarbons,
regardless of specific gravity, whether singly or in combination with other substances; and (ii) natural gas, synthetic gas usable for fuel, and mixtures of natural gas and such synthetic gas. If Tenant, its employees, agents contractors,
subtenants, licensees, concessionaires, invitees or guests shall violate this provision, Tenant shall indemnify, defend, and hold Landlord, its affiliates and their employees, agents, officers, directors, members and managers, harmless from and
against the following: 
 (a) any loss, cost, expense, claim, liability, injury or damage (incidental, consequential, indirect
and direct), including, but not limited to, reasonable attorneys fees and expert and consulting fees, arising out of any investigation, monitoring, clean-up, containment, removal, storage, or restoration work (herein referred to as “Remedial
Work”) required by, or incurred by Landlord or any other person or party in a reasonable belief that such Remedial Work is required by any applicable federal, state or local law, rule, regulation or order, or by any governmental agency,
authority, or political subdivision having jurisdiction over the Premises, and 
 (b) any claims of third parties for any loss,
cost, expense, claim, liability, injury or damage (incidental, consequential, indirect and direct), including, but not limited to, reasonable attorneys fees and expert and consulting fees, arising out of the presence, release, threatened release or
discharge of any Hazardous Materials on, under, in, above, to, or from the Premises. 
 In the event any Remedial Work is
required under any applicable federal, state, or local law, rule, regulation or order, as a result of any violation by Tenant of the foregoing, Tenant shall promptly perform or cause to be performed such Remedial Work in compliance with such
law, rule, regulation, or order. In the event Tenant shall fail to commence the Remedial Work in a timely fashion, or shall fail to prosecute diligently the Remedial Work to completion, such failure shall constitute an Event of Default on the part
of Tenant under the terms of this Lease, and Landlord, in addition to any other rights or remedies afforded it hereunder, may, but shall not be obligated to, upon thirty (30) days prior notice to Tenant (except in the event of exigent
circumstances), cause the Remedial Work to be performed, and Tenant shall promptly reimburse Landlord for the cost and expense thereof upon demand. 
 Landlord represents and warrants to Tenant that, to the best of Landlord’s knowledge, as of the Commencement Date, no Hazardous Materials are present on, under, in or above the Property in violation
of any applicable federal, state or local laws, rules, regulations or orders. Landlord shall indemnify, defend and hold Tenant, its directors, employees, and officers harmless from and against any loss, cost or damage arising out of any Hazardous
Materials being present on, under, in or above the Property as of the Commencement Date, or arising out of any Hazardous Materials present, released or discharged following the Commencement Date which are the result of the acts or omissions of
Landlord. 
 ARTICLE 8. - CONDEMNATION 
 8.1 Substantial Taking. If in the reasonable determination of Landlord all or a substantial part of the Premises are taken for any public or quasi-public use under any governmental law, ordinance
or regulation, or by right of eminent domain or by purchase in lieu thereof, and in the reasonable determination of Landlord and Tenant the taking would prevent or materially interfere with the use of the Premises for the purpose for which it is
then being used, this Lease shall, at the option of either Landlord or Tenant, terminate and the Rent shall be abated during the unexpired portion of this Lease effective on the date physical possession is taken by the condemning authority.

 8.2 Partial Taking. If in the reasonable determination of Landlord a portion of the Premises shall be taken for any
public or quasi-public use under any governmental law, ordinance or regulation, or by right of eminent domain or by purchase in lieu thereof, 

  
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 and this Lease is not terminated as provided in Section 8.1 above, Landlord shall restore and
reconstruct, to the extent of condemnation proceeds (excluding any proceeds for land) actually received after the exercise by any mortgagee of the Property of an option to apply such proceeds against Landlord’s debt to such mortgagee, the
Property and other improvements on the Premises to the extent necessary to make it reasonably tenantable. The Base Rent payable under this Lease during the unexpired portion of the term shall be reduced to an amount determined by multiplying the
Base Rent that would otherwise be payable but for this provision by the ratio that the portion of the Premises not rendered untenantable bears to the total net rentable area of the Premises prior to the casualty. If Landlord fails to substantially
complete such restoration and reconstruction within one hundred and eighty (180) working days of the date of the physical possession by the condemning authority, Tenant may at its option terminate this Lease by delivering written notice of
termination to Landlord, whereupon all rights and obligations of this Lease shall cease to exist. 
 8.3 Condemnation
Proceeds. All compensation awarded for any taking (or the proceeds of private sale in lieu thereof), whether for the whole or a part of the Premises, shall be the property of Landlord (whether such award is compensation for damages to
Landlord’s or Tenant’s interest in the Premises) and Tenant hereby assigns all of its interest in any such award to Landlord; provided, however, Landlord shall have no interest in any award made to Tenant for loss of business or for taking
of Tenant’s fixtures and other property within the Premises if a separate award for such items is made to Tenant. 
 ARTICLE
9. - ASSIGNMENT OR SUBLEASE 
 9.1 Tenant Assignment. Tenant shall not assign, in whole or in part, this Lease, or allow
it to be assigned, in whole or in part, by operation of law or otherwise (including without limitation by merger, dissolution or transfer of a controlling interest in any partnership or corporate Tenant unless such transfer of control occurs in
connection with any public offering of the Shares of Common Stock of the Tenant or if such transfer of control results from additional debt or equity financings, which merger, dissolution or transfer shall be deemed an assignment) or mortgage or
pledge the same, or sublet the Premises, in whole or in part, without the prior written consent of Landlord, not to be unreasonably withheld, conditioned, or delayed, and in no event shall any such assignment or sublease ever release Tenant or any
guarantor from any obligation or liability hereunder. No assignee or sublessee of the Premises or any portion thereof may assign or sublet the Premises or any portion thereof without also obtaining such consent from Landlord. Notwithstanding
the foregoing, Tenant may, without Landlord’s consent but upon notice to Landlord, assign this Lease or sublet the Premises, in whole or in part, to any entity controlled by, controlling or under common control with Tenant or to any entity
succeeding to Tenant or Tenant’s business by merger or purchase of assets, provided the assignee’s credit is at least as good as Tenant’s at the time of the Commencement Date. 

9.2 Conditions of Tenant Assignment. If Tenant desires to assign or sublet all or any part of the Premises, it shall so notify
Landlord in writing at least thirty (30) days in advance of the date on which Tenant desires to make such assignment or sublease. Tenant shall provide Landlord with a copy of the proposed assignment or sublease and such information as Landlord
might reasonably request concerning the proposed sublessee or assignee to allow Landlord to make informed judgments as to the financial condition, reputation, operations and general desirability of the proposed sublessee or assignee. Within fifteen
(15) days after Landlord’s receipt of Tenant’s proposed assignment or sublease and all required information concerning the proposed sublessee or assignee, Landlord shall have the following options: 

(1) cancel this Lease as to the Premises or portion thereof proposed to be assigned or sublet; 

(2) consent to the proposed assignment or sublease, and, if the rent due and payable by any assignee or sublessee under any such
permitted assignment or sublease (or a combination of the rent payable under such assignment or sublease plus any bonus or any other consideration or any payment incident thereto) exceeds the rent payable under this Lease for such space, Tenant
shall pay to Landlord one-half of all such excess rent and other excess consideration within ten (10) days following receipt thereof by Tenant; or 
 (3) refuse, in its reasonable discretion and judgment, to consent to the proposed assignment or sublease, which refusal shall be deemed to have been exercised unless Landlord gives Tenant written notice
stating otherwise. 
 Upon the occurrence of an event of default by Tenant under this Lease, if all or any part of the Premises
are then assigned or sublet, Landlord, in addition to any other remedies provided by this Lease or provided by law, may, at its option, collect directly from the assignee or sublessee all rents becoming due to Tenant by reason of the assignment or
sublease, and Landlord shall have a security interest in all properties belonging to Tenant on the Premises to secure payment of such sums. No collection directly by Landlord from the assignee or sublessee shall be construed to constitute a novation
or a release of Tenant or any guarantor from the further performance of its obligations under this Lease. All reasonable legal fees and expenses incurred by Landlord in connection with the review by Landlord of Tenant’s requested assignment or
sublease pursuant to this Section, together with any reasonable legal fees and disbursements incurred in the preparation and/or review of any documentation, shall be the responsibility of Tenant and shall be paid by Tenant within five (5) days
of demand for payment thereof, as rental hereunder. If the rent due and payable by any assignee or sublessee under any such permitted assignment or sublease (or a combination of the rent payable under such assignment or sublease plus any bonus or
any other consideration or any payment incident thereto) exceeds the Rent payable under this Lease for such space, Tenant shall pay to Landlord one-half of such excess rent and other excess consideration within ten (10) days, following receipt
thereof by Tenant. 
 9.3 Landlord Assignment. Landlord shall have the right to sell, transfer or assign, in whole or in
part, its rights and obligations under this Lease and in the Property. Any such sale, transfer or assignment shall operate to release Landlord from any and all liabilities under this Lease arising after the date of such sale, assignment or transfer
except to the extent that Landlord fails to transfer the Security Deposit. 
 9.4 Rights of Mortgagee. Tenant accepts
this Lease subject and subordinate to any recorded lease, mortgage or deed of trust lien presently existing, if any, or hereafter encumbering the Property and to all existing ordinances and recorded restrictions, covenants, easements, and agreements
with respect to the Property. Landlord hereby is irrevocably vested with full power and authority to subordinate Tenant’s interest under this Lease to any mortgage or deed of trust lien hereafter placed on the Property. Upon any foreclosure,
judicially or non-judicially, of any such mortgage, or the sale of the Property in lieu of foreclosure, or any other transfer of Landlord’s interest in the Property, whether or not in connection with a mortgage, Tenant hereby does, and
hereafter agrees to attorn to the purchaser at such foreclosure sale or to the grantee under any deed in lieu of foreclosure or to any other transferee of Landlord’s interest, and shall recognize such purchaser, grantee, or other transferee as
Landlord under this Lease, and no further attornment or other agreement shall be required to effect or evidence Tenant’s attornment to and recognition of such purchaser or grantee as Landlord hereunder provided Tenant is given a Non-Disturbance
and Attornment Agreement. Such agreement of Tenant to attorn 

  
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 shall survive any such foreclosure sale, trustee’s sale, conveyance in lieu thereof, or any other
transfer of Landlord’s interest in the Property. Tenant, upon demand, at any time, before or after any such foreclosure sale, trustee’s sale, conveyance in lieu thereof, or other transfer shall execute, acknowledge, and deliver to the
prospective transferee and/or mortgage a Lease Subordination, Non-Disturbance and Attornment Agreement and any additional written instruments and certificates evidencing such attornment as the mortgagee or other prospective transferee may reasonably
require. Notwithstanding anything to the contrary implied in this Section, any mortgagee under any mortgage shall have the right at any time to subordinate any such mortgage to this Lease on such terms and subject to such conditions as the mortgagee
in its discretion may consider appropriate. 
 9.5 Estoppel Certificates. Tenant agrees to furnish, from time to time,
within ten (10) days after receipt of a request from Landlord or Landlord’s mortgagee, a statement certifying, if applicable, all or some of the following: Tenant is in possession of the Premises; the Lease is in full force and effect; the
Lease is unmodified (except as disclosed in such statement); Tenant claims no present charge, lien, or claim of offset against Rent; the Rent is paid for the current month, but it is not prepaid for more than one (1) month and will not be
prepaid for more than one (1) month in advance; there is no existing default by reason of some act or omission by Landlord; that Landlord has performed all inducements required of Landlord in connection with this Lease, including construction
obligations, and Tenant accepts the Premises as constructed; an acknowledgment of the assignment of rentals and other sums due hereunder to the mortgagee and agreement to be bound thereby; an agreement requiring Tenant to advise the mortgagee of
damage to or destruction of the Premises by fire or other casualty requiring reconstruction; an agreement by Tenant to give the mortgagee written notice of Landlord’s default hereunder and to permit the mortgagee to cure such default within a
reasonable time after such notice before exercising any remedy Tenant might possess as a result of such default; and such other matters as may be reasonably required by Landlord’s mortgagee. Tenant’s failure to deliver such statement, in
addition to being a default under this Lease, shall be deemed to establish conclusively that this Lease is in full force and effect except as declared by Landlord, that Landlord is not in default of any of its obligations under this Lease, and that
Landlord has not received more than one (1) month’s Rent in advance. 
 ARTICLE 10. - LIENS 

10.1 INTENTIONALLY DELETED 
 10.2 INTENTIONALLY DELETED 
 10.3 Upon request of Tenant or Tenant’s
assignees or any subtenant, Landlord shall execute and deliver a Landlord Waiver in the form attached hereto as Exhibit H. 

ARTICLE 11. - DEFAULT AND REMEDIES 
 11.1 Default by Tenant. The following shall be deemed to be events of default by Tenant under this Lease: 
 (1) Tenant shall fail to pay within five (5) days of written notice any installment of Rent or any other payment required pursuant to this Lease; 

(2) Tenant shall vacate, abandon or cease to operate its business for a period of more than 5 business days in any substantial portion
of the Premises (other than for renovation or casualty) (If Tenant vacates or ceases to operate its business in the Premises it must continue to comply with all other obligations of the Lease and maintain one (1) full-time security guard in the
Premises during normal business hours.); 
 (3) Tenant or any guarantor of Tenant’s obligations hereunder shall file a
petition or be adjudged bankrupt or insolvent under any applicable federal or state bankruptcy or insolvency law or admit that it cannot meet its financial obligations as they become due, or a receiver or trustee shall be appointed for all or
substantially all of the assets of Tenant or any guarantor of Tenant’s obligations hereunder; 
 (4) Tenant or any
guarantor of Tenant’s obligations hereunder shall make a transfer in fraud of creditors or shall make an assignment for the benefit of creditors; 
 (5) Tenant shall do or permit to be done any act which results in a lien being filed against the Premises or the Property; 
 (6) the liquidation, termination, dissolution or (if the Tenant is a natural person) the death of Tenant or any guarantor of Tenant’s obligations hereunder; 

(7) Tenant shall be in default of any other term, provision or covenant of this Lease, and such default is not cured within thirty
(30) days after written notice thereof to Tenant. 
 11.2 Remedies for Tenant’s Default. Upon the occurrence of
any event of default set forth in this Lease, Landlord shall have the option to pursue any one or more of the remedies set forth in this Section 11.2 without any additional notice or demand: 

(1) Without declaring the Lease terminated, Landlord may enter upon and take possession of the Premises, by picking or changing locks if
necessary, and lock out, expel or remove Tenant and any other person who may be occupying all or any part of the Premises without being liable for any claim for damages, and relet the Premises and receive the rent directly by reason of the
reletting. Tenant agrees to pay Landlord on demand all amounts then due under this Lease, any deficiency that may arise by reason of any reletting of the Premises and the unpaid balance of any amortized construction cost of Tenant improvements;
further, Tenant agrees to reimburse Landlord for any reasonable expenditure made by it in order to relet the Premises, including, but not limited to, remodeling and repair costs, brokerage commissions free rent or rental concessions and
attorneys’ fees. 
 (2) Without declaring the Lease terminated, Landlord may enter upon the Premises, by picking or
changing locks if necessary, without being liable for any claim for damages, and do whatever Tenant is obligated to do under the terms of this Lease. Tenant agrees to reimburse Landlord on demand for any reasonable expenses which Landlord may incur
in effecting compliance with Tenant’s obligations under this Lease; further, Tenant agrees that Landlord shall not be liable for any damages resulting to Tenant from effecting compliance with Tenant’s obligations under this Lease caused by
the negligence of Landlord or otherwise. 
 (3) Landlord may terminate this Lease, in which event Tenant shall immediately
surrender the Premises to Landlord, and if Tenant fails to surrender the Premises, Landlord may, without prejudice to any other remedy which it may have for 

  
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possession or arrearages in rent, enter upon and take possession of the Premises, by picking or changing locks if necessary, and lock out, expel or remove Tenant and any other person who may be
occupying all or any part of the Premises without being liable for any claim for damages. Tenant agrees to pay on demand the amount of all loss and damage which Landlord may suffer for any reason due to the termination of this Lease under this
Section 11.2, including (without limitation) past due amounts, any remaining unpaid balance of amortized construction costs, loss and damage due to the failure of Tenant to maintain and/or repair the Premises as required hereunder and/or due to
the inability of Landlord to relet the Premises on reasonably satisfactory terms or otherwise. 
 Landlord’s exercise,
following a default by Tenant under this Lease, of any right granted hereunder or under any applicable law to lock out or change the locks securing the Premises shall not impose upon Landlord any duty to notify Tenant of the name and address or
telephone number of the individual or company from whom a new key may be obtained, nor shall Landlord have any duty to provide Tenant with a new key or any other means of access to the Premises. To the maximum extent permitted by law, Landlord and
Tenant agree that the parties hereto intend that all rights and remedies of Landlord under this Lease shall supersede any conflicting provisions of the General Statutes of North Carolina, and any amendments, modifications, recodification or other
changes thereto. 
 Notwithstanding any other remedy set forth in this Lease, if Landlord has made rent concessions of any type
or character, or waived any Base Rent, and Tenant fails to take possession of the Premises on the Commencement Date or otherwise defaults at any time during the term of this Lease beyond any applicable cure periods, the rent concessions, including
any waived Base Rent, shall be canceled and the amount of the Base Rent or other rent concessions shall be due and payable immediately as if no rent concessions or waiver of any Base Rent had ever been granted. A rent concession or waiver of the
Base Rent shall not relieve Tenant of any obligation to pay any other charge due and payable under this Lease. Notwithstanding anything contained in this Lease to the contrary, this Lease may be terminated by Landlord only by written notice of such
termination to Tenant given in accordance with Section 13.7 below, and no other act or omission of Landlord shall be construed as a termination of this Lease. 
 11.3 Remedies Cumulative. All rights and remedies of Landlord herein or existing at law or in equity are cumulative and the exercise of one or more rights or remedies shall not be taken to exclude
or waive the rights to the exercise of any other. 
 ARTICLE 12. - DEFINITIONS 

12.1 Abandon. “Abandon” means the vacating of all or a substantial portion of the Premises by Tenant or of any Landlord
approved assignee or sublet tenant, whether or not Tenant is in default of the rental or other payments due under this Lease. 

12.2 Act of God or Force Majeure. An “act of God” or “force majeure” is defined for purposes of this Lease as
strikes, lockouts, sitdowns, material or labor restrictions by any governmental authority, unusual transportation delays, riots, floods, washouts, explosions, earthquakes, fire storms, weather (including wet grounds or inclement weather which
prevents construction), acts of the public enemy, wars, insurrections, and/or any other cause not reasonably within the control of a party or which by the exercise of due such party is unable wholly or in part, to prevent or overcome.

 ARTICLE 13. - MISCELLANEOUS 
 13.1 Waiver. Failure of Landlord to declare an event of default immediately upon its occurrence, or delay in taking any action in connection with an event of default, shall not constitute a waiver
of the default, but Landlord shall have the right to declare the default at any time and take such action as is lawful or authorized under this Lease. Pursuit of any one or more of the remedies set forth in Article 11 above shall not preclude
pursuit of any one or more of the other remedies provided elsewhere in this Lease or provided by law, nor shall pursuit of any remedy hereunder or at law constitute forfeiture or waiver of any rent or damages accruing to Landlord by reason of the
violation of any of the terms, provisions or covenants of this Lease. Failure by Landlord to enforce one or more of the remedies provided hereunder or at law upon any event of default shall not be deemed or construed to constitute a waiver of the
default or of any other violation or breach of any of the terms provisions and covenants contained in this Lease. Waiver by Landlord of any default by Tenant hereunder shall in no event be deemed or construed to be a waiver of identical or similar
future defaults. Landlord may collect and receive rent due from Tenant without waiving or affecting any rights or remedies that Landlord may have at law or in equity or by virtue of this Lease at the time of such payment. To the maximum extent
allowable pursuant to applicable law, institution of a summary ejectment action to re-enter the Premises shall not be construed to be an election by Landlord to terminate this Lease. 

13.2 Act of God. Neither party shall be required to perform any covenant or obligation in this Lease, or be liable in damages to
the other party, so long as the performance or non-performance of the covenant or obligation is delayed, caused or prevented by an act of God, force majeure or by such other party. 

13.3 Attorney’s Fees. If either party defaults in the performance of any of the terms, covenants agreements or conditions
contained in this Lease and the non-defaulting party places in the hands of any attorney the enforcement of all or any part of this Lease, the collection of any rent or other sums due or to become due or recovery of the possession of the Premises,
the defaulting party agrees to pay the non-defaulting party’s cost of collection, including reasonable attorneys’ fees, whether suit is actually filed or not. 
 13.4 Successors. This Lease shall be binding upon and inure to the benefit of Landlord and Tenant and their respective heirs, personal representatives, successors and assigns. 

13.5 Rent Tax. If applicable in the jurisdiction where the Premises are situated, Tenant shall pay and be liable for all rental,
sales and use taxes or other similar taxes, if any, levied or imposed by any city, state, county or other governmental body having authority, such payments to be in addition to all other payments required to be paid to Landlord by Tenant under the
terms of this Lease. Any such payment shall be paid concurrently with the payment of the Base Rent, Additional Rent, Common Area Costs, or other charge upon which the tax is based as set forth above. 

13.6 Interpretation. The captions appearing in this Lease are for convenience only and in no way define, limit, construe or
describe the scope or intent of any Section. Grammatical changes required to make the provisions of this Lease apply (1) in the plural sense where there is more than one tenant and (2) to either corporations, associations, partnerships or
individuals, males or females, shall in all instances be assumed as though in each case fully expressed. The laws of the State of North Carolina shall govern the validity, performance and enforcement of this Lease. This Lease shall not be construed
more or less favorably with respect to either party as a consequence of the Lease or various provisions hereof having been drafted by one of the parties hereto. 
 13.7 Notices. All rent and other payments required to be made by Tenant shall be payable to Landlord, in care of Manager, at Manager’s address set forth on page 1 (or if no address be set
forth for Manager, to Landlord at Landlord’s address set forth on page 1). All payments required to be made by Landlord to Tenant shall be payable to Tenant at Tenant’s address set forth on

  
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page 1. Any notice or document (other than rent) required or permitted to be delivered by the terms of this Lease shall be deemed to be delivered when deposited in the United States Mail, postage
prepaid, certified mail, return receipt required, addressed to the parties at the respective addresses set forth on page 1, or to such other addresses as the parties may have designated by written notice to each other, with copies of notices to
Landlord being sent to Landlord’s address as shown on page 1. Manager shall be a co-addressee with Landlord on all notices sent to Landlord by Tenant hereunder, and any notice sent to Landlord and not to Manager, also, in accordance with this
section shall be deemed ineffective. 
 13.8 Submission of Lease. SUBMISSION OF THIS LEASE TO TENANT FOR SIGNATURE DOES
NOT CONSTITUTE A RESERVATION OF SPACE OR AN OPTION TO LEASE. THIS LEASE IS NOT EFFECTIVE UNTIL EXECUTION BY BOTH LANDLORD AND TENANT. 
 13.9 Corporate Authority. If Tenant executes this Lease as a corporation or a partnership (general or limited), Tenant represents and warrants that: Tenant is a duly authorized and existing
corporation or partnership (general or limited), Tenant is qualified to do business in the state in which the Premises are located, the corporation or partnership (general or limited) has full right and authority to enter into this Lease, each
person signing on behalf of the corporation or partnership (general or limited) is authorized to do so, and the execution and delivery of the Lease by Tenant will not result in any breach of, or constitute a default under any mortgage, deed of
trust, lease, loan, credit agreement, partnership agreement, or other contract or instrument to which Tenant is a party or by which Tenant may be bound. 
 13.10 Multiple Tenants. If this Lease is executed by more than one person or entity as “Tenant,” each such person or entity shall be jointly and severally liable hereunder. It is
expressly understood that any one of the named Tenants shall be empowered to execute any modification, amendment, exhibit, floor plan, or other document herein referred to and bind all of the named Tenants thereto; and Landlord shall be entitled to
rely on same to the extent as if all of the named Tenants had executed same. 
 13.11 Tenant’s Financial Statements.
Tenant represents and warrants to Landlord that, as of the date of execution of this Lease by Tenant, the financial statements, if any, of Tenant provided to Landlord prior to or simultaneously with the execution of this Lease accurately represent
the financial condition of Tenant as of the dates and for the periods indicated therein, such financial statements are true and do not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the
statements included therein not misleading and there has been no material adverse change in the financial condition or business prospects of Tenant since the respective dates of such financial statements. If there is a material adverse change in
Tenant’s financial condition, Tenant will give immediate notice of such material adverse change to Landlord. If Tenant fails to give such immediate notice to Landlord, such failure shall be deemed an event of default under this Lease. Landlord
agrees to keep all financial or other information received from Tenant strictly confidential and will not disclose such information to any person other than Landlord’s mortgagees, accountants, attorneys or employees who have a need to know such
information. 
 13.12 Severability. If any provision of this Lease or the application thereof to any person or
circumstances shall be invalid or unenforceable to any extent, the remainder of this Lease and the application of such provisions to other persons or circumstances shall not be affected thereby and shall be enforced to the greatest extent permitted
by law. Each covenant and agreement contained in this Lease shall be construed to be a separate and independent covenant and agreement, and the breach of any such covenant or agreement by Landlord shall not discharge or relieve Tenant from
Tenant’s obligation to perform each and every covenant and agreement of this Lease to be performed by Tenant. 
 13.13
Landlord’s Liability. If Landlord shall be in default under this Lease and, if as a consequence of such default, Tenant shall recover a money judgment against Landlord, such judgment shall be satisfied only out of the right, title and
interest of Landlord in the Property as the same may then be encumbered and neither Landlord nor any other person or entity comprising Landlord shall be liable for any deficiency. In no event shall Tenant have the right to levy execution against any
property of Landlord other than the Property, nor any person or entity comprising Landlord other than its interest in the Property as herein expressly provided. 
 13.14 Sale of Property. Upon any conveyance, sale or exchange of the Premises or assignment of this Lease, Landlord shall be and is hereby entirely free and relieved of all liability under any and
all of its covenants and obligations contained in or derived from this Lease arising out of any act, occurrence, or omission relating to the Premises or this Lease occurring after the consummation of such sale or exchange and assignment. 

13.15 Time is of the Essence. The time of the performance of all of the covenants, conditions and agreements of this Lease is of
the essence. 
 13.16 Subtenancies. At Landlord’s option, the voluntary or other surrender of this Lease by Tenant,
or a mutual cancellation thereof, shall not work a merger of estates and shall operate as an assignment of any or all permitted subleases or subtenancies. 
 13.17 Common Areas. Landlord reserves the right to change, from time to time, the dimensions and location, identity and type of any buildings comprising the Building, and to construct additional
buildings or additional stories on existing buildings or other improvements on the Property, provided that such changes and additional construction do not materially or adversely affect parking and signage for the Premises. Landlord reserves the
right to change, from time to time, the dimensions and location of the Common Area and to allow the Common Area to be put to such uses, as Landlord shall, from time to time, deem desirable, provided that Tenant’s use and enjoyment of, access to
and parking for the Premises and/or the Common Areas is not materially adversely affected thereby for an unreasonable period of time and during such time Tenant has an alternate means of access to the Premises. Tenant and its employees and customers
shall have the nonexclusive right to use the Common Area in common with Landlord, other tenants of the Property and other persons designated by Landlord, subject to reasonable rules and regulations governing use that Landlord from time to time
prescribes. Tenant shall not solicit business, distribute handbills or display merchandise within the Common Area, or take any action, which would interfere with the rights of other persons to use the Common Area. Landlord may temporarily close any
part of the Common Area to make repairs or alterations. Tenant acknowledges that Landlord may be required to grant to major tenants of the Property the right to display and sell merchandise and services on portions of the Common Area, and the rights
herein granted to Tenant shall be inferior to any such rights granted to major tenants. The Common Area shall be under Landlord’s sole operation and control. Tenant shall be responsible for and shall indemnify and hold Landlord harmless from
any liability, loss or damage arising out of or caused by Tenant, its employees, subtenants, licensees, concessionaires, agents, suppliers, vendors, or service contractors, to any part of the Common Area, or to the Property whether such damages be
structural or nonstructural. 
 13.18 Parking. Landlord will provide, at no additional cost, as many parking spaces as
required by the City of Raleigh (for the square footage of the Premises’ but in no event less than two and one-half (2.5) spaces per one thousand (1,000) square feet. Landlord may, from time to time, designate specific areas in which
vehicles owned by Tenant and its employees shall be parked, and Tenant shall use best efforts to see that such vehicles are parked in such areas. Upon request, Tenant shall furnish to Landlord a complete list of the license numbers of all vehicles
operated by Tenant and its employees. 
 Please Initial 

  
 Page 11 of 12

 13.19 Tenant’s Indemnities. All representations, warranties and indemnities
given by Tenant or Landlord pursuant to this Lease shall survive the expiration or earlier termination of the Lease Term. 

ARTICLE 14. - AMENDMENT AND LIMITATION OF WARRANTIES 
 14.1 Entire Agreement. IT IS EXPRESSLY AGREED BY TENANT, AS A MATERIAL CONSIDERATION FOR THE EXECUTION OF THIS LEASE, THAT THIS LEASE, WITH THE SPECIFIC REFERENCES TO EXTRINSIC DOCUMENTS, IS THE
ENTIRE AGREEMENT OF THE PARTIES; THAT THERE ARE, AND WERE, NO VERBAL REPRESENTATIONS, WARRANTIES, UNDERSTANDINGS, STIPULATIONS, AGREEMENTS OR PROMISES PERTAINING TO THE SUBJECT MATTER OF THIS LEASE OR OF ANY EXPRESSLY MENTIONED EXTRINSIC DOCUMENTS
THAT ARE NOT INCORPORATED IN WRITING IN THIS LEASE OR IN SUCH DOCUMENTS. 
 14.2 Amendment. THIS LEASE MAY NOT BE
ALTERED, WAIVED, AMENDED OR EXTENDED EXCEPT BY AN INSTRUMENT IN WRITING SIGNED BY LANDLORD AND TENANT. 
 14.3 Limitation of
Warranties. LANDLORD AND TENANT EXPRESSLY AGREE THAT THERE ARE AND SHALL BE NO IMPLIED WARRANTIES OF MERCHANTABILITY, HABITABILITY, SUITABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OF ANY OTHER KIND ARISING OUT OF THIS LEASE, AND THERE ARE NO
WARRANTIES WHICH EXTEND BEYOND THOSE EXPRESSLY SET FORTH IN THIS LEASE. WITHOUT LIMITING THE GENERALITY OF THE FOREGOING, TENANT EXPRESSLY ACKNOWLEDGES THAT LANDLORD HAS MADE NO WARRANTIES OR REPRESENTATIONS CONCERNING ANY HAZARDOUS SUBSTANCES OR
OTHER ENVIRONMENTAL MATTERS AFFECTING ANY PART OF THE PROPERTY, AND LANDLORD HEREBY EXPRESSLY DISCLAIMS AND TENANT WAIVES ANY EXPRESS OR IMPLIED WARRANTIES WITH RESPECT TO ANY SUCH MATTERS. 

14.4 Waiver and Releases. TENANT SHALL NOT HAVE THE RIGHT TO WITHHOLD OR TO OFFSET RENT OR TO TERMINATE THIS LEASE EXCEPT AS
EXPRESSLY PROVIDED HEREIN. TENANT WAIVES AND RELEASES ANY AND ALL STATUTORY LIENS AND OFFSET RIGHTS. 
 14.5 Non-Disclosure
of Lease Terms. NOTWITHSTANDING ANYTHING CONTAINED WITHIN THIS LEASE TO THE CONTRARY, IF TENANT DISCLOSES ANY OF THE MATERIAL TERMS AND/OR PROVISIONS OF THIS LEASE, INCLUDING BUT NOT LIMITED TO THE BASE RENT, TENANT’S COMMON AREA COSTS OR
ANY CAPS ON SUCH COSTS, THE TENANT FINISH OUT ALLOWANCE, TENANT’S PROPORTIONATE SHARE OF GENERAL TAXES OR ANY CAP ON SUCH EXPENSE, TENANT’S PROPORTIONATE SHARE OF INSURANCE PREMIUMS OR ANY CAP ON SUCH EXPENSE, OR THE LEASE TERM TO ANY
PERSON OR ENTITY NOT A PARTY TO THIS LEASE, EXCEPT TENANT’S ATTORNEY AND TENANT’S REAL ESTATE REPRESENTATIVE (BUT ONLY TO BE USED FOR PURPOSES OF THIS TRANSACTION AND NO OTHER), THEN TENANT SHALL BE LIABLE FOR ALL DAMAGE OR INJURY TO
LANDLORD RESULTING FROM TENANT’S FAILURE TO KEEP ALL SUCH INFORMATION CONFIDENTIAL AND TENANT SHALL INDEMNIFY AND HOLD LANDLORD HARMLESS FROM ANY DAMAGE, LOSS OR INJURY OCCASIONED THEREBY. IN THE ALTERNATIVE, AND AT LANDLORD’S SOLE OPTION,
IF DAMAGES ARE DIFFICULT TO CALCULATE, TENANT SHALL PAY LIQUIDATED DAMAGES EQUAL TO ONE (1) MONTH’S BASE RENT AS DEFINED IN ARTICLE 1 HEREOF. 
 14.6 The parties shall prepare, execute and record a memorandum of this Lease, which shall include a summary of the basic terms of the Lease, including the names of the parties, the Lease Term, and all
extended term periods, a description of the Premises. 
 15.1 Addendum. The Addendum attached hereto is incorporated
herein by reference as if set forth verbatim. In the event of a conflict between the terms and conditions of the Addendum and the Lease, the Addendum shall govern and control. All terms defined herein have the same meaning in the Addendum as herein.

 IN WITNESS WHEREOF, the parties have executed this Lease causing their respective seals to be affixed hereto. 

EXECUTED by Tenant on
                                         
                   , 2001, and by Landlord on October 4, 2001, to be effective upon full execution by Landlord and Tenant. 

  

									
		 		 	LANDLORD:
			
		 		 	PARKER-RALEIGH DEVELOPMENT XXX, LLC
		 		 	By:	 	Parker Lincoln Developers, Inc.,	 	
		 		 		 	its Managing Agent	 	
					
	ATTEST:	 		 		 		 	
					
	 /s/ Vickie B. Poor
	 		 	By:	 	 /s/ David L. Brady, CEO 
	 	(SEAL)
	Asst. Secretary	 		 		 	Vice President	 	
					
	(CORPORATE SEAL)	 		 		 		 	
			
		 		 	TENANT:
			
		 		 	LIPOMED, INC.,
		 		 	 a Delaware corporation

					
	ATTEST:	 		 		 		 	
					
	 /s/ Fred D. Hutchison
	 		 	By:	 	 /s/ Richard A. Franco
	 	(SEAL)
	Asst. Secretary	 		 	                           
  Chairman	 	
					
	(CORPORATE SEAL)	 		 	Name:	 	  
	 	
		 		 		 	Type or Print 	 	

  
 Page 12 of 12

 Exhibit A 
 Legal Description 
 Parker Business Center 

Building #307 

2540 Sumner Boulevard 
 Raleigh, NC 27616 
 BEING all of Lot 16 (consisting of 3.507 acres) as shown on Plat entitled
“Subdivision and Right of Way Dedication Map of Parker Business Center” prepared by Kenneth Close, Inc., Land Surveying, and recorded in Book of Maps 1998, Page 201, Wake County Registry. 

Parker Business Center 
 Building #308 
 2500 Sumner Boulevard 

Raleigh, NC 27616 
 BEING all of
Lot 17 (consisting of 3.016 acres) as shown on Plat entitled “Recombination Map of Parker Business Center Lots 17 - 19” prepared by Kenneth Close, Inc., Land Surveying, and recorded in Book of Maps 2000, Page 1781, Wake County Registry.

 EXHIBIT B 
 SITE PLAN 
 Parker Business Center 

Raleigh, North Carolina 
 [MAP APPEARS HERE] 

 EXHIBIT C 
 BUILDING PLAN 
 Parker Business Center 

Buildings 307, 308 and the Connector 
 2500 Sumner Boulevard, Raleigh, NC 27616 

 EXHIBIT D 
 Commencement Letter 

 EXHIBIT E 
 RULES & REGULATIONS 
 The following rules and regulations will remain in full force and
affect until Landlord notifies Tenant of any changes in writing. 
  

	 	1.	Access to the Building. Access to the Premises shall be gained by use of a key to the outside doors of the Premises. Landlord may, from time to time, establish
security controls for the purpose of regulating access to the Building. Tenant shall abide by all such security regulations to be established. 

  

	 	2.	Protecting Premises. Before leaving the Premises unattended, Tenant shall close and securely lock all doors or other means of entry to the Premises. Tenant must
maintain an adequate number of suitable fire extinguisher on the Premises at all times for use in case of fire, including electrical or chemical fires. 

  

	 	3.	Large Articles. Furniture, freight and other large or heavy articles may be brought into the Building only at times and in the manner designated by Landlord and
always at Tenant’s sole responsibility. All damage to the Building, its furnishing, fixtures or equipment by moving or maintaining such furniture, freight or articles shall be repaired at the expense of Tenant. 

 

	 	4.	Signs. Tenant shall not paint, display, inscribe, maintain or affix any sign, placard, picture, advertisement, name, notice, lettering or direction on any part
of the outside or inside of the Building, or on any part of the inside of the Premises which can be seen from the outside of the Premises, without the written consent of the Landlord, and then only such name or names or matter and in such color,
size, style, character and material as shall be first approved Landlord in writing. Landlord reserves the right to remove, at the Tenant’s expense, all matter other than that above provided for without notice to Tenant. Under no circumstances
shall Tenant display or cause or allow to be displayed, on or in the Premises, any sign for a real estate company, broker, brokerage company or person or company engaged in the leasing of real property other than Parker Lincoln Commercial Realty,
Inc. Further, Tenant shall not place a “For Rent” or “For Lease” sign in or on the Premises. 

  

	 	5.	Compliance with Laws. Tenant shall comply with all applicable laws, ordinances, governmental orders or regulations and applicable orders or directions from any
public office or body having jurisdiction, whether now existing or hereinafter enacted with respect to the Premises and the use or occupancy thereof. Tenant shall not make permit any use of the Premises which directly or indirectly is forbidden by
law, ordinance, governmental regulations or order or direction of applicable public authority, or which may be dangerous to person or property. 

  

	 	6.	Waste Disposal. Tenant must keep, and prepare for collection, all garbage and refuse in a container approved by Landlord. Landlord must also approve the location
of the container. Tenant will be responsible for the cost of container and the cost of trash removal. Tenant must not burn trash or garbage of any kind on or about the Premises or the Building or Property where located. 

 

	 	7.	Antenna or satellite dish. Tenant may not erect any aerial, antenna or satellite dish on the roof or exterior walls of the Premises or on the grounds. Any such
installation will be subject to removal without notice at any time. 

  

	 	8.	Obstruction of Public Areas. Tenant may not place or permit any obstructions, materials or equipment in the outside areas adjoining the Premises without the
written consent of the Landlord. All equipment, merchandise, freight or other materials must be moved inside the Premises at the end of each business day. Tenant shall not, whether temporarily, accidentally or otherwise, allow anything to remain in,
place or store anything in, or obstruct in any way, any sidewalk, court, passageway, entrance, or shipping area. Tenant shall lend its full cooperation to keep such areas free from all obstruction and in a clean and sightly condition, and move all
supplies, furniture and equipment as soon as received directly to the Premises, and shall move all such items and waste (other than waste customarily removed by the Building employees) that are any time being taken from the Premises directly to the
areas designated for disposal. All courts, passageways, entrances, exits, elevators, escalators, stairways, corridors, halls and roofs are not for the use of the general public and Landlord shall in all cases retain the right to control and prevent
access thereto by all persons whose presence in the judgement of Landlord shall be prejudicial to the safety, character, reputation and interest of the Building and its tenants; provided, however, that nothing herein contained shall be construed to
prevent such access to persons with whom Tenant deals within the normal course of Tenant’s business unless such persons are engaged in illegal activities. 

 
 

	 	9.	Defacing Premises and Overloading. Tenant shall not place anything or allow anything to be placed in the Premises near the glass of any door, partition, wall or
window, which may be unsightly from outside the Premises. Tenant shall not place or permit to be placed any article of any kind on any window ledge or on the exterior walls: blinds, shades, awnings or other forms of inside or outside window
ventilators or similar devices shall not be placed in or about the outside windows in the Premises. Tenant shall not do any painting or decorating in the Premises or install any floor coverings in the Premises or make, paint, cut or drill into, or
in any way deface any part of the Premises or Building without in each instance obtaining the prior written consent of Landlord. Tenant shall not overload any floor or part thereof in the Premises, or any facility in the Building or any public
corridors or elevators therein by bringing in or removing any large or heavy articles and Landlord may direct and control the location of safes, files, and all other heavy articles and, if considered necessary by Landlord, require supplementary
supports at Tenant’s expense of such material and dimensions necessary to properly distribute the weight. 

  

	 	10.	Additional Locks. Tenant shall not attach or permit to be attached additional locks or similar devices to any door or window, change existing locks or the
mechanism thereof, or make or permit to be made any keys for any door 

  
 Page 1 of 3

	 	 
other than those provided by Landlord. Upon termination of this lease or termination of Tenant’s possession, Tenant shall surrender all keys to the Premises. 

 

	 	11.	Communications or Utility Connections. If Tenant desires signal, alarm or other utility or similar service connections installed or changed, Tenant shall not
install or change the same without the approval of Landlord, and then only under the direction of Landlord and at Tenant’s expense. Tenant shall not install in the Premises any equipment, which requires a substantial amount of electrical
current without the advance written consent of Landlord. Tenant shall ascertain from Landlord the maximum amount of load or demand for or use of electrical current, which can safely be permitted in the Premises, taking into account the capacity of
the electric wiring in the Building, and shall not in any event connect a greater load that which is safe. 

Tenant shall not operate any electrical device from which may emanate electrical waves, which may interfere with or impair radio or
television broadcasting or reception from or in the Building or elsewhere and/or cause distributing noises or vibrations. Tenant shall not use any illumination or power for the operation of any equipment or device other than electricity. 

 

	 	12.	Parking. Parking is in designated parking areas only. There should not be any parking in the “no parking” zones or at curbs. Handicapped spaces are for
handicapped persons and the Police Department will ticket unauthorized (unidentified) cars in handicapped spaces. Tenant’s employees should not use visitor parking spaces. Storage of vehicles on the parking lot is prohibited except with the
written consent of the Landlord. Landlord will designate tenant employee parking. 

  

	 	13.	Pest Control. Tenant must keep the Premises free from pests, insects and rodents by using a professional pest-exterminating contractor when needed, at
Tenant’s expense. 

  

	 	14.	Restrooms. The restrooms, toilets, urinals, vanities and the other apparatus shall not be used for any purpose other than that for which they were constructed
and no foreign substance of any kind whatsoever shall be thrown therein and the expense of any breakage, stoppage, or damage resulting form the violation of this rule shall be borne by Tenant who, or whose employees or invitees, shall have caused
it. 

  

	 	15.	Solicitation. Tenant shall not make any room-to-room canvass to solicit business from other tenants in the Building or on the Property and shall not exhibit,
sell or offer to sell, use, rent or exchange any products or services in or from the Premises unless ordinarily embraced within the Tenant’s use of the Premises specified herein and specific authority granted in the Lease. Tenant, his
employees, and agents, may not solicit business in the parking lot or other common areas and may not distribute handbills or other advertising matter in automobiles parked in the parking area or other common area. 

 

	 	16.	Energy Conservation. Tenant shall not waste electricity, water, heat or air conditioning and agrees to cooperate fully with Landlord to assure the most effective
operation of the Building’s heating and air conditioning, and shall not allow the adjustment (except by Landlord’s authorized Building personnel) of any controls. 

 

	 	17.	Intoxication. Landlord reserves the right to exclude or expel from the Property any person who, in the judgement of Landlord, is intoxicated or under the
influence of liquor or drugs, or who shall in any manner do any act in violation of any of the rules and regulations of the Property. 

  

	 	18.	Nuisances and Certain Other Prohibited Uses. Tenant shall not: 

  

	 	(a)	engage in any mechanical business, utilize any article or thing, or engage in any service in or about the Premises or Property, except those ordinarily embraced within
the permitted use of the Premises; 

  

	 	(b)	use the Premises for housing, lodging, or sleeping purposes; 

  

	 	(c)	create excessive noise, place a musical or sound producing instrument or device inside or outside the Premises which may be heard outside the Premises;

  

	 	(d)	bring or permit to be in the Building any bicycle or other vehicle, or dog (except in the company of a blind person) or other animal or bird; 

 

	 	(e)	cause or permit any noxious or offensive odors, fumes, gases, smoke, dust, steam or vapors; 

 

	 	(f)	do anything in or about the Premises tending to create or maintain a nuisance or do any act tending to injure the reputation of the Property. 

 

	 	19.	HVAC Equipment. All heating and air conditioning equipment must be maintained by Tenant and inspected and serviced by a qualified, licensed contractor on a
quarterly basis. The quarterly inspections and service must occur no later than March 31, June 30, September 30, and December 31 of each calendar year. Within ten (10) days of each quarterly inspection and service
date, Tenant must provide to Landlord a report from the contractor performing such inspection and service. If the Commencement Date of Tenant’s Lease is less than sixty-day (60 days) from the next scheduled quarterly inspection and service
date, Tenant shall be permitted to skip such inspection and service and begin on the following date. If Tenant fails to have the quarterly inspection and service performed in accordance with this provision or fails to provide the required report to
Landlord, Landlord may have the inspection and service performed and bill Tenant for the cost thereof plus a 15% administrative cost. 

  
 Page 2 of 3

	 	20.	Window Treatments. If Tenant desires to install window coverings, Landlord must approve them in writing before installation. 

 

	 	21.	Amendment of Rules & Regulations. Landlord reserves the right to amend or waive any of the foregoing rules or regulations at any time when, in its
judgement, it is in the property’s best interests and the Tenant’s best interests. No such amendment or waiver of any rules and regulation in favor of one Tenant operates as an alteration or waiver in favor of any other Tenant. Landlord is
not responsible to any Tenant for the non-observance or violation by any other Tenant of any of these rules and regulations at any time. 

  
 Page 3 of 3

 EXHIBIT F 
 FLOOR PLAN 
 Parker Business Center 

Buildings 307, 308 and the Connector 
 2500 Sumner Boulevard, Raleigh, NC 27616 

 EXHIBIT G 
 Sign Criteria 
 Parker Business Center 

Buildings 307, 308 and the Connector 
 2500 Sumner Boulevard, Raleigh, NC 27616 

 ADDENDUM 
 This Addendum is attached to and incorporated by reference in the lease by and between PARKER-RALEIGH DEVELOPMENT XXX, LLC (“Landlord”) and LIPOMED, INC. (“Tenant”) dated
October 4, 2001 (the “Lease”). In the event of a conflict between the terms and conditions of this Addendum and the Lease, this Addendum shall govern and control. All terms defined in the Lease shall have the same meaning herein.
Except as modified herein, all provisions of the Lease shall be in full force and effect. 
 The following shall constitute
additional provisions or conditions to the Lease: 
  

	 	1.	Construction of the Premises. The Premises are comprised of Buildings 307 and 308 and the Connector between the Buildings. Tenant desires, and Landlord has
agreed, to construct improvements (the “Improvements”) to the exterior and interior of the Premises to meet the needs of Tenant’s business operations. Landlord will construct the Connector and the Improvements in accordance with
construction plans (the “Construction Plans”) to be prepared by Landlord’s architects and engineers. The Construction Plans for Building 307 will be submitted to Tenant for review and approval within ten (10) days of execution
hereof and Tenant shall respond to Landlord with all comments within five (5) days of receipt. Both Landlord and Tenant must approve the Construction Plans within twenty (20) days of execution hereof. 

Within forty-five (45) days of the execution of the Lease, Landlord will deliver to Tenant the Construction Plans for Building 308
and the Connector. Tenant shall have ten (10) days to review and comment on the Construction Plans for Building 308 and the Connector. The parties must agree on the Building 308 and the Connector Construction Plans within sixty (60) days
of execution of the Lease. Upon approval, the Construction Plans for Building 307, Building 308, and the Connector will be attached to the Lease as an exhibit and incorporated herein by reference. Landlord and Tenant will work in good faith to agree
on the Construction Plans for all the Buildings. 
 Interior Improvements: Landlord will provide to Tenant a construction
allowance not to exceed thirty dollars ($30) per square foot of the Premises (85,000 square feet) (the “Interior Fit-Up Allowance”) for the construction of the interior Improvements. Landlord will construct the interior Improvements in
accordance with the Construction Plans. If the cost of the interior Improvements exceeds the Interior Fit-Up Allowance, the excess shall be at Tenant’s sole expense. Upon completion of the interior Improvements for each Building and prior to
occupancy of each Building, if there is any excess costs over the Interior Fit-Up Allowance, Tenant shall reimburse Landlord in current funds for Landlord’s expenses of every kind and nature in connection with construction of the interior
Improvements, including, but not limited to, all amounts paid by Landlord to the general contractor for materials, labor, and services, plus overhead and profit of sixteen percent (16%). In the event that the total cost of the interior Improvements
is less than the Interior Fit-Up Allowance, the difference shall be applied to Tenant’s monthly Base Rent under the Lease. 

Prior to commencement of construction of the interior Improvements for each Building, Landlord will submit to Tenant a breakdown of the
construction costs. Within five (5) days of receipt of the breakdown, Tenant may review, in Landlord’s offices, Landlord’s supporting documentation. The final cost of the interior Improvements for Building 307 must be agreed upon
between Landlord and Tenant within thirty (30) days of full execution hereof. The final cost of the interior Improvements for Building 308 and the Connector must be agreed upon within sixty (60) days of execution hereof. 

Exterior Improvements: Landlord will construct the following Improvements to the exterior of the Buildings as shown on the Construction
Plans: 
  

	 	(a)	install edge levelers on four (4) existing docks; 

  

	 	(b)	replace all other existing dock overhead doors with windows; 

  

	 	(c)	install “spandrel glass” on the exterior ends of the Buildings and the side of the Connector facing Sumner Boulevard; 

 

	 	(d)	construct the “special entry feature”; and 

  
 Page 1 of 6

	 	(e)	construct two outside break areas (each with one thousand (1,000) square feet of concrete pad and two hundred (200) square feet of awning.

  

	 	2.	Construction Delays. In the event that completion of the Buildings is delayed due to any act or omission of Tenant or its agents, including but not limited to,
design changes, change orders, failure to timely give an approval or improperly timed activities which are Tenant’s responsibility (“Tenant Delay”) then, in that event, the Rental Waiver for both Buildings shall be reduced on a
day-for-day basis. If the Tenant Delay is longer than fourteen (14) days, Rent shall commence on the anticipated completion dates for each Building (December 15, 2001, for Building 307 and July 1,2002, for Building 308 and the Connector)
irrespective of completion of the Improvements or occupancy by Tenant. 

 In the event that completion of the
Buildings is delayed for any reason other than a Tenant Delay, Rent shall not commence until fifteen (15) days after the Commencement Date for each Building, and otherwise there shall be no other penalty to Landlord. 

 

	 	3.	Rental Waiver. As consideration for Tenant’s performance of all obligations under the Lease, Landlord hereby conditionally waives the Base Rent for the
first fourteen (14) days of the Lease Term for each Building, provided Tenant shall not be in default hereunder. Should Tenant at any time during the Lease Term be in default, the total sum of such Base Rent so conditionally waived shall become
immediately due and payable by Tenant to Landlord. If at the expiration of this Lease, including any option or renewal periods, Tenant is not in default hereunder, Landlord shall permanently waive payment of the conditionally waived Base Rent. This
waiver does not include Common Area Costs Payment, which Tenant shall begin paying on the Commencement Date. 

  

	 	4.	Letter of Credit. Simultaneously with the execution of the Lease, Tenant will provide to Landlord a clean, unconditional, irrevocable, payable-at-sight letter of
credit, which shall conform, in all material respects, to the form attached hereto as Exhibit H in the stated principal amount of $1,500,000.00, drawn on a bank chartered in North Carolina and approved by Landlord (the “Letter of Credit”).

 The Letter of Credit shall name Landlord as its beneficiary and shall remain outstanding until thirty
(30) days after the expiration of the Lease Term, including all extensions and renewals. If there shall be an event of default under the Lease, in addition to the remedies set forth in Section 11.2 of the Lease, Landlord shall have the
right immediately, without further notice, to draw on the Letter of Credit in whole or in part at Landlord’s sole discretion to reimburse Landlord for the default and all related costs. If Landlord elects to allow Tenant to cure the event of
default, which Landlord shall not be obligated to do, Tenant must provide to Landlord a replacement letter of credit in the same amount and with the same terms, and pay to Landlord a nonrefundable fee of $5,000.00 to reimburse Landlord for its costs
associated with drawing upon the Letter of Credit. 
 The Letter of Credit may be reduced as follows: 

 

	 	(a)	on January 1, 2003: to $1,000,000.00 on the condition that Tenant had not less than $2,500,000.00 in gross sales each month for the year 2002 and 2002 annual net
income of not less than $5,400,000.00 for 2002, solely from its United States operations, coronary heart disease division (the “US Heart Division”); 

 

	 	(b)	on July 1, 2003: to $500,000.00 on the condition that the requirements of (a) were timely met and, in addition, the US Heart Division had not less than
$4,000,000.00 in gross sales each month and $6,960,000.00 in net income for the first six (6) months of 2003; 

  

	 	(c)	on January 1, 2004: to an amount equal to two (2) months of the then current Rent on the condition that the requirements of (a) and (b) were timely met
and, in addition, that the US Heart Division had not less than $5,000,000.00 in gross sales each month and a net income of $8,700,000.00 for the last six (6) months of 2003. (Subparagraphs (a), (b), (c) are collectively the “Financial
Benchmarks”). 

 The Financial Benchmarks must exclude all inter-company sales, transfers, and other such
transactions. The Financial Benchmarks must be based upon examination, by an independent certified public accountant (“CPA”) reasonably acceptable to Landlord, of Tenant’s audited (unqualified) balance sheets, statements of income,
retained earnings and statement of cash flow (collectively “Tenant’s Financial Statements”) for the years in question. The examination must be made in accordance with generally accepted auditing standards. The CPA must determine in
his or her opinion that the Financial Statements present fairly the financial 

  
 Page 2 of 6

 
position of the Tenant in conformity with generally accepted accounting principles (“GAAP”) applied on a consistent basis. The CPA must express an unqualified opinion based on agreed
upon procedures, verifying that Tenant’s US Heart Division has achieved the applicable Financial Benchmarks. Landlord will respond to Tenant within ten (10) days of receipt of the audited Financial Statements and an acceptable CPA
verification. Immediately upon receipt of the audited Financial Statements and Landlord’s acceptance of the CPA verification, Tenant may reduce the Letter of Credit. 
 The Letter of Credit will remain at two (2) months Rent for the balance of the Lease Term including any renewals and extensions. Tenant may substitute a cash deposit of an equal amount for the Letter
of Credit in which case Section 2.8 of the Lease shall apply. 
  

	 	5.	Renewal Options. On the condition that Tenant has fully complied with all the terms and conditions of the Lease, and on the further condition that Tenant gives
Landlord one hundred eighty (180) days advance written notice of its desire to exercise its option to renew (failure to give notice being an absolute bar to any right on the part of the Tenant to so renew), Landlord hereby gives to Tenant the
right to renew this Lease for two (2) terms of five (5) additional years each at the then current Base Rent plus three percent (3%). Thereafter, the Base Rent shall increase annually by three percent (3%). The Common Area Costs shall be at
Landlord’s then current rate. Except as provided above for Base Rent, the same terms and conditions as set forth in the Lease shall govern the parties’ rights and obligations during the renewal term. 

 

	 	6.	Expansion Options. To accommodate Tenant’s expansion needs, Landlord hereby gives Tenant an option to lease (the “Expansion Option”) up to one
hundred percent (100%), but not less than fifty percent (50%), of a building of approximately one-hundred thousand ( 100,000) square feet, or of whatever size the City of Raleigh will allow (the “Expansion Building”) to be constructed by
Landlord on the land shown on the attached Exhibit B-1. The initial term of the Expansion Option shall commence upon the Commencement Date hereof and shall automatically expire on January 1, 2003. The Expansion Option shall be at no cost to
Tenant for the initial term. 

 If Tenant elects to lease the Expansion Building, such lease shall contain
substantially the same terms and conditions as in this Lease with the specific business terms to be agreed upon between the parties within thirty (30) days of receipt of detailed plans and specifications for the Tenant Improvements. Landlord
will provide to Tenant a “bid” to construct the new building and all improvements. If Tenant elects to lease one hundred percent (100%) of the Expansion Building, Tenant may obtain bids for the construction from two other qualified,
licensed, general contractors. If Tenant wishes to use one of the other contractors, Tenant must submit the bid and all supporting and related documentation to Landlord. Upon receipt of the competing bid with supporting documentation, Landlord will
have thirty (30) days to notify Tenant as to whether Landlord will match the bid or allow Tenant to use the other contractor. If Landlord elects to allow Tenant to use the other contractor, Tenant must do so and, prior to commencing
construction, must deliver to Landlord a letter of credit in the amount of the bid and in the form required by the Lease as shown on Exhibit H. If Tenant elects to lease less than one hundred percent (100%) of the Expansion Building, Tenant
must use Landlord for all construction. 
 All negotiations concerning the Expansion Option must be conducted in good faith with
the parties using their best efforts to reach an agreement. All negotiations and a fully executed lease must be completed prior to the expiration of the Expansion Option term (initial or extended, as applicable), failure to do so being an absolute
bar of Tenant’s rights under the Expansion Option. Time is of the essence with regard to the Expansion Option 
  

	 	7.	Tenant’s Right to Audit. Tenant shall have the right to audit Landlord’s Books and Records upon the following conditions: 

a. So long as no event of default by Tenant has occurred beyond any applicable cure periods, nor any other event with which the passage of
time or the giving of notice, or both, would constitute an event of default by Tenant, under this Lease, Tenant, or its representative, shall have the right, at Tenant’s sole expense, to inspect and copy Landlord’s books and records
relating to any Common Area Cost reconciliation statement (the “Reconciliation Statement”) for the purpose of verifying the information contained therein (the “Tenant Audit”), provided that: 

 

	 	i.	Tenant shall have sent notice, in writing, no later than ninety (90) days after receipt of the Reconciliation Statement to be verified, of its desire to conduct the
Tenant Audit (the “Audit Notice”); 

  
 Page 3 of 6

	 	ii.	The Audit Notice identifies with specificity the particular item(s) in the Reconciliation Statement that the Tenant believes is/are incorrect; and,

  

	 	iii.	Tenant has paid the Reconciliation Statement in full. 

  

	 	b.	Procedures for Review. 

  

	 	i.	The Tenant Audit shall be conducted only: 

  

	 	(A)	By an independent firm of certified public accountants of national standing that is not being compensated by Tenant on a contingency fee basis; and

  

	 	(B)	During regular business hours at the office where Landlord maintains its books and records. 

 

	 	ii.	The Tenant Audit shall commence by no later than thirty (30) days after Landlord’s receipt of the Audit Notice, and shall be completed within five
(5) business days after such commencement. 

  

	 	iii.	A copy of the results of the Tenant Audit shall be delivered to Landlord within thirty (30) days after the completion of the Tenant Audit.

  

	 	c.	Waiver. If Tenant fails to timely request the Tenant Audit as required by subparagraph (a) hereof, or the results of the Tenant Audit are not timely delivered to
Landlord as required by subparagraph (b) hereof, or Tenant fails to follow any of the procedures set forth in subparagraph (b) hereof, then such Reconciliation Statement shall be deemed to have been approved and accepted by Tenant as
correct. 

  

	 	d.	Limitations on Tenant Audit. 

  

	 	i.	The Tenant Audit shall be limited strictly to those items in the Reconciliation Statement that Tenant has specifically identified in writing as being allegedly
incorrect. 

  

	 	ii.	Tenant shall not be entitled to inspect any of Landlord’s books and records that apply to any prior Reconciliation Statements or to any calendar year other than
the year covered by the most recent Common Area Cost Reconciliation Statement delivered to Tenant unless Tenant was due a credit for an overpayment (pursuant to subparagraph (f) hereof) in a Tenant Audit of a Reconciliation Statement, and then
solely: 

  

	 	(A)	in connection with the same specific item that was the subject of the previous Tenant Audit in which Tenant was due a credit; and 

 

	 	(B)	for the two (2) years immediately preceding the calendar year for which Tenant was due a credit in such inspection, but in no event shall Tenant be entitled to
conduct an inspection for a period earlier than three (3) years prior to the year in which Landlord delivers the most recent Reconciliation Statement. 

 

	 	iii.	Tenant shall be entitled to no more than one (1) Tenant Audit per calendar year. 

 

	 	iv.	no subtenant has any right to conduct a Tenant Audit and no assignee shall conduct a Tenant Audit for any period during which such assignee was not in possession of the
Premises. 

  

	 	v.	once having conducted a Tenant Audit with respect to a specific item of a Reconciliation Statement in any year, Tenant shall have no right to conduct another Tenant
Audit of the same specific item for such year. 

  

	 	vi.	if Tenant violates this Lease at any time during the Tenant Audit, the Tenant Audit shall immediately cease and the matters originally set forth in the Common Area Cost
Reconciliation Statement shall be deemed to be correct. 

  

	 	e.	Confidential Information. Tenant acknowledges and agrees that any records reviewed under this Clause constitute confidential information of Landlord, which shall not be
disclosed to anyone other than: 

  

	 	i.	the auditor performing the Tenant Audit; 

  

	 	ii.	 the principals of Tenant who receive the results of the Tenant Audit. Tenant further acknowledges and agrees that the disclosure of information to any
other person, whether by Tenant or anyone acting on behalf of Tenant, shall constitute a material 

  
 Page 4 of 6

	 	 
breach of this Lease. Accordingly, Tenant and its auditor shall execute and deliver to Landlord a confidentiality agreement prepared by Landlord, in favor of Landlord, prior to any Tenant Audit.

  

	 	f.	Overpayment. In the event that the results of the Tenant Audit reveal that Tenant has overpaid its obligations and is due a credit for a preceding period, Landlord
shall credit the amount due against Tenant’s next installment(s) of its obligations of estimated Common Area Costs Payments. Tenant will not have the right to terminate the Lease on account of an overpayment. 

 

	 	g.	Under-billing. In the event that, as a result of the Tenant Audit, it is ascertained that Tenant has been under-billed for a preceding period, Tenant shall pay the
amount of such under-billing to Landlord with the next installment obligation of estimated Common Area Costs Payments. 

  

	 	h.	Costs of Tenant Audit. Tenant shall pay Landlord, on demand and as Additional Rent, Landlord’s invoice for: 

 

	 	i.	the photocopying of documents; 

  

	 	ii.	the retrieval of documents from Landlord’s storage archives; 

  

	 	iii.	the time spent by Landlord’s employees in supervising, coordinating, and cooperating with the Tenant Audit; 

 

	 	iii.	any other expenses of Landlord incidental to the Tenant Audit: and, 

  

	 	iv.	in the event the Tenant Audit reflects that Tenant has been overcharged by Landlord by an amount greater than five percent (5%) of the total charge, Landlord shall
reimburse Tenant for the reasonable cost of the Tenant Audit. 

 [END OF DOCUMENT; SIGNATURE PAGE FOLLOWS.]

  
 Page 5 of 6

 IN WITNESS WHEREOF, the parties have executed this Addendum causing their respective seals
to be affixed hereto. 
 EXECUTED by Tenant on
                                        ,
2001, and by Landlord on October 4, 2001, to be effective upon full execution by Landlord and Tenant. 
  

											
		 		 	LANDLORD:
			
		 		 	PARKER-RALEIGH DEVELOPMENT XXX, LLC
		 		 	By:	 	Parker Lincoln Developers, Inc.,
		 		 		 	 its Managing Agent

						
	ATTEST:	 		 		 		 		 	
					
	 /s/ Vickie B. Poor
	 		 	By:	 	 /s/ David L. Brady, CEO
	 	(SEAL)
	Asst. Secretary	 		 		 	 Vice President
	 	
						
	(CORPORATE SEAL)	 		 		 		 		 	
			
		 		 	TENANT:
			
		 		 	LIPOMED, INC.,
		 		 	a Delaware corporation
						
	ATTEST:	 		 		 		 		 	
					
	 /s/ James Otvos
	 		 	By:	 	 /s/ Richard A. Franco
	 	(SEAL)
	James Otvos Secretary	 		 		 	 Chairman
	 	
						
	(CORPORATE SEAL)	 		 		 		 		 	
		 		 	Name:	 	 Richard A. Franco
	 	
		 		 		 		 	 Type or Print
	 	

  
 Page 6 of 6

 STATE OF NORTH CAROLINA 

 

					
		 		 	LEASE AMENDMENT NO. 1

 COUNTY OF
WAKE 
 THIS LEASE AMENDMENT is made this 5TH day of MARCH 2002, by and between PARKER-RALEIGH DEVELOPMENT XXX,
LLC (“Landlord”) and LIPOSCIENCE, INC. (“Tenant”). 
 WHEREAS, Landlord and Tenant
(collectively the “Parties”) entered into a written agreement of Lease executed October 4, 2001 (the “Lease”) whereby the Landlord leased to Tenant approximately 85,000 square feet of space located at 2500 Sumner Boulevard,
Raleigh, North Carolina 27615 (the “Premises”); and, 
 WHEREAS, the Tenant name has been changed and the
parties wish to amend the Lease to reflect the change; and, 
 WHEREAS, the parties desire to further amend and modify
the Lease as hereinafter set forth. 
 NOW, THEREFORE, by mutual agreement of the parties and in consideration of the
mutual promises and obligations hereinafter set forth, the Lease is hereby amended and modified as follows: 
  

	 	I.	Delete “LipoMed, Inc.” wherever it appears in the Lease and substitute in its place: 

LipoScience, Inc. 
 In the event of a conflict between the terms and conditions of the Lease and this Amendment, this Amendment shall govern and control. All terms defined in the Lease shall have the same meaning herein.
Except as modified herein all terms and conditions of the Lease are ratified and confirmed in all other respects. 
 IN
WITNESS WHEREOF, the parties hereto have hereunto executed this Lease Amendment No. 1 in triplicate causing their respective seals to be affixed hereto the day and year first above written. 

 

									
		 		 	LANDLORD:
			
		 		 	PARKER-RALEIGH DEVELOPMENT XXX, LLC
		 		 	By:	 	Parker Lincoln Developers, Inc.,
		 		 		 	    its Managing Agent
					
	ATTEST:	 		 		 		 	
					
	
 

	 		 	By:	 	
 

	 	(SEAL)
			
	    Asst     Secretary	 		 	    Vice     President
					
	(CORPORATE SEAL)	 		 		 		 	
		
	

	 	
	 	TENANT:
	 	 LIPOSCIENCE, INC.,
     a Delaware corporation

					
	ATTEST:	 		 		 		 	
					
	
 

	 		 	By:	 	
 

	 	(SEAL)
					
	  

 

	 	Secretary	 	Title:	 	 Chairman
	 	
				
	(CORPORATE SEAL)	 	Name:	 	
 

	 	
		 		 		 	 Type or Print

  

					
		 	Page 1 of 1	 	

 STATE OF NORTH CAROLINA 
 LEASE AMENDMENT NO. 2 
 COUNTY OF WAKE 

THIS LEASE AMENDMENT is made this 28th day of August 2002, by and between PARKER-RALEIGH DEVELOPMENT XXX, LLC
(“Landlord”) and LIPOSCIENCE, INC. (“Tenant”). 
 WHEREAS, Landlord and Tenant entered
into a written agreement of Lease dated October 4, 2001 and amended by Lease Amendment No. 1 (collectively the “Lease”) whereby the Landlord leased to Tenant approximately 85,000 square feet of space located at 2500 Sumner
Boulevard, Raleigh, North Carolina 27615 (the “Premises”); and, 
 WHEREAS, the square footage of the Premises
was incorrectly stated in the Lease as 85,000 square feet and the parties wish to amend the Lease to reflect the correct square footage as 82,785 square feet; and, 
 WHEREAS, the parties desire to further amend and modify the Lease as hereinafter set forth. 
 NOW, THEREFORE, by mutual agreement of the parties and in consideration of the mutual promises and obligations hereinafter set forth, the Lease is hereby amended and modified as follows:

  

	 	1.	The foregoing recitals are true and correct and are incorporated herein by reference. 

 

	 	2.	Delete paragraph 1.5 of the Lease and substitute in its place: 

 1.5 Premises. The floor space and interior wall and ceiling space of that portion of the Buildings outlined in red or highlighted on Exhibit C attached hereto, resulting in an aggregate of
approximately 82,785 square feet of gross leasable area known as Buildings 307 (39,820 square feet) and 308 (33,220 square feet) and a 9,745 square foot connector (the “Connector”) between Building 307 and Building 308, all as shown on
Exhibit C. Landlord will construct the “Improvements” (as defined in the Addendum) and deliver Building 307 to Tenant first. The Commencement Date for Building 307 is anticipated to be December 15, 2001. Prior to completion of the
Improvements in Building 307, Landlord will begin construction of the Improvements in Building 308 and the Connector. The Commencement Date for the Connector and Building 308 is anticipated to be July 1, 2002. 

 

	 	3.	Delete paragraph 1.8 of the Lease and substitute in its place: 

 1.8 Base Rent. Base Rent is: 
  

													
	 Months
	  	Per Square Foot	 	  	Annually	 	  	Monthly	 
	 1 through 6 – Building 307
	  	$	11.85	  	  	 	N/A	  	  	$	39,322.25	  
	 Approximately 7 through 12 – Buildings 307, 308, and the Connector
	  	$	11.85	  	  	 	N/A	  	  	$	81,750.19	  
	 13 through 24
	  	$	12.15	  	  	$	1,005,837.75	  	  	$	83,819.81	  
	 25 through 36
	  	$	12.45	  	  	$	1,030,673.25	  	  	$	85,889.44	  
	 37 through 48
	  	$	12.76	  	  	$	1,056,336.60	  	  	$	88,028.05	  
	 49 through 60
	  	$	13.08	  	  	$	1,082,827.80	  	  	$	90,235.65	  
	 61 through 72
	  	$	13.41	  	  	$	1,110,146.85	  	  	$	92,512.24	  
	 73 through 84
	  	$	13.75	  	  	$	1,138,293.75	  	  	$	94,857.81	  
	 85 through 96
	  	$	14.09	  	  	$	1,166,440.65	  	  	$	97,203.39	  

  

					
		 	Page 1 of 2	 	

													
	 97 through 108
	  	$	14.44	  	  	$	1,195,415.40	  	  	$	99,617.95	  
	 109 through 120
	  	$	14.80	  	  	$	1,225,218.00	  	  	$	102,101.50	  
	 121 through 126 + 14 days
	  	$	15.17	  	  	$
 	676,762.82
(6 months, 14 days)	  
  	  	$	104,654.04	  

 In the event of a
conflict between the terms and conditions of the Lease and this Amendment, this Amendment shall govern and control. All terms defined in the Lease shall have the same meaning herein. Except as modified herein all terms and conditions of the Lease
are ratified and confirmed in all other respects. 
 IN WITNESS WHEREOF, the parties hereto have hereunto executed this
Lease Amendment No. 2 in triplicate causing their respective seals to be affixed hereto the day and year first above written. 
  

									
	 	 	 	 	LANDLORD:
			
		 		 	PARKER-RALEIGH DEVELOPMENT XXX, LLC
		 		 	By:	 	Parker Lincoln Developers, Inc.,
		 		 		 	    its Managing Agent
				
	ATTEST:	 		 		 	
					
	
 

	 		 	By:	 	
 

	 	(SEAL)
					
	    ASST     Secretary	 		 		 	    VICE     President	 	
			
	(CORPORATE SEAL)	 		 	
		
	
 

	 	TENANT:
			
		 		 	LIPOSCIENCE, INC.,
		 		 	 a Delaware corporation

					
	ATTEST:	 		 		 		 	
					
	
 

	 		 	By:	 	
 

	 	(SEAL)
					
	
 

	 	Secretary	 	Title:	 	 EVP & CFO
	 	
				
	(CORPORATE SEAL)	 	Name:	 	
 

	 	
		 		 		 	 Type or Print
	 	

  

					
		 	Page 2 of 2

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