Document:

EX-10.8

 Exhibit 10.8 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(c) and Rule 406 of the 

Securities Act of 1933, as amended. 

SUPPORT SERVICES AGREEMENT 

THIS SUPPORT SERVICES AGREEMENT (this
“Agreement”) is made and entered into as of October 10, 2017 (the “Effective Date”), by and between SYNTHORX, INC., a Delaware Corporation (the
“Company”), and COI PHARMACEUTICALS, INC., a Delaware Corporation (the “Service Provider”). 

RECITALS 

WHEREAS, the Company possesses the rights to certain intellectual property relating to unnatural base
pair biotechnology (the “Technology”), which it desires to further research and develop; 

WHEREAS, the Company currently has limited operational resources and therefore desires to engage Service
Provider to provide additional operational resources and services (including personnel, facilities and equipment) intended to assist the Company in pursuing its business plan of researching and developing the Technology, in each case on the terms
and conditions set forth in this Agreement; and 
 WHEREAS, Service Provider desires to accept the
engagement by the Company. 
 NOW, THEREFORE, in
consideration of the foregoing premises and the mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree as follows: 

AGREEMENT 
  

	1.	     SERVICES. 

1.1        Description of Services.  Subject to the terms and
conditions of this Agreement, the Company hereby engages Service Provider, and Service Provider hereby accepts the engagement by the Company, to provide the services described on Exhibit A, or of a similar nature, as may reasonably be
requested by the Company and reasonably approved by Service Provider from time to time following the date hereof (the “Services”). 

1.2        Service Provider Personnel.  For such time as any
personnel of Service Provider are performing Services: (i) such personnel will remain employees of Service Provider and will not be deemed to be employees of the Company for any purpose; and (ii) Service Provider shall be solely
responsible for [...***...]. In addition, Service Provider expressly acknowledges and agrees that it will be solely responsible for the performance of the Services by all personnel of Service Provider performing any of the Services, and shall
at all times cause such personnel to comply with all of the obligations of Service Provider set forth in this Agreement. 
  

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	1.3	         General Obligations; Standard of Care.

     (a)        Performance
Requirements.  Service Provider shall provide Services in accordance with the terms of this Agreement and in accordance with its policies, procedures and practices then in effect, and shall exercise substantially the same care and
skill as it exercises in performing similar activities to the Services for itself. 

    (b)        Separation.  Service
Provider shall use all reasonable efforts to distinguish the Services performed under this Agreement from other work the Service Provider performs for itself or any third parties (collectively, “Other Work”), and shall keep
records pertaining to such Other Work separately from the records to be maintained pursuant to Section 5.5 below. 

    (c)        Communication.  On a regular
basis during the Term, the parties shall conduct meetings, either in person or by telephone or video conference, to discuss the progress and results of the Services. 

    (d)        Key Providers.  It is the
present intention of Service Provider that substantially all of the Services will be provided and/or overseen by the individuals as specified on Exhibit B hereto (the “Key Providers”), subject to modification from time
to time in consultation with the Company. 
 2.        SERVICE
FEES.  In consideration of Service Provider’s performance of the Services, the Company shall pay to Service Provider the quarterly fees for Services provided in accordance with the schedule of fees set forth
on EXHIBIT A hereto (the “Service Fees”). Such Service Fees shall be: (i) paid to Service Provider in advance of each calendar quarter during the Term, commencing with an initial payment on the
Effective Date in respect of the first calendar quarter during the Term and continuing thereafter with payments due on the first (1st) business day of each calendar quarter during the Term in respect of each such calendar quarter; and
(ii) prorated and refunded (or applied forward to future Service Fees, in each case as directed by the Company) as necessary for any unearned Service Fees paid during the quarter in which Services are provided. 

3.        EXPENSES.  The Company shall [...***...]
incurred by Service Provider in connection with the provision of the Services, provided Service Provider must: (i) obtain the prior written approval of the Company for all such expenses in excess of $[...***...]; and (ii) submit such
written documentation of all such expenses as the Company may reasonably require. Any advance payments by the Company for Service Fees may be credited toward the reimbursement of any expenses eligible for reimbursement pursuant to the provisions
hereof. Within thirty (30) days of the end of each calendar quarter Service Provider will invoice or refund Company (or apply forward to future Service Fees and expense reimbursements that may become due hereunder, as directed by the Company)
as necessary for any under-payment or over payment for such expenses. 

4.        INDEPENDENT CONTRACTOR
RELATIONSHIP.  Service Provider’s relationship with the Company shall be solely that of an independent contractor, and nothing in this Agreement shall be construed to create a partnership, joint venture or
employer-employee relationship. Service Provider is not the agent of the Company and is not authorized to make any representation, contract or commitment on behalf of the Company. Service Provider shall not be entitled to any of the 

 
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 2. 

 benefits that the Company may make available to its employees, such as group insurance,
profit-sharing or retirement benefits. Service Provider shall be solely responsible for all tax returns and payments required to be filed with or made to any federal, state or local tax authority with respect to Service Provider’s and its
personnel’s performance of the Services and Service Provider’s receipt of any compensation pursuant to this Agreement. The Company will regularly report amounts paid to Service Provider by filing Form 1099-MISC with the Internal Revenue
Service as required by law. 
  

	5.	     INFORMATION AND INTELLECTUAL
PROPERTY RIGHTS. 

5.1        Confidentiality.  Service Provider agrees that it
shall at all times take all steps reasonably necessary to hold all Proprietary Information (as defined below) to which Service Provider has access in trust and confidence, shall not use such Proprietary Information in any manner or for any purpose
except as expressly set forth in this Agreement and shall not disclose any such Proprietary Information to any third party without first obtaining the Company’s express written consent on a case-by-case basis; provided, however, that Service Provider may disclose certain Proprietary Information, without violating its obligations under this Agreement, to the extent such disclosure
is required by a valid order of a court or other governmental body having jurisdiction, provided that Service Provider provides the Company with reasonable prior written notice of such disclosure and uses his [...***...] to obtain, or
to assist the Company in obtaining, a protective order preventing or limiting the disclosure and/or requiring that the Proprietary Information so disclosed be used only for the purposes for which the law or regulation required, or for which the
order was issued. “Proprietary Information” means (a) the Company Work Product (as defined below) and (b) any and all other data, information, technology, samples and specimens of the Company or its products,
product concepts, technologies, businesses, financial, marketing, clinical or regulatory affairs, manufacturing processes and procedures, or those of any other third party (including Third-Party Information, as defined below), provided or otherwise
made available to Service Provider or to which Service Provider otherwise has access, either directly or indirectly and whether in written, graphic or verbal form. 

5.2        Limitations.  Service Provider shall not be obligated to
treat information as Proprietary Information if Service Provider can show by competent evidence that such information: 

 (a)        was already known to Service Provider without any obligations
of confidentiality prior to receipt from Company (provided this exception will not apply to Company Work Product); 

 (b)        was generally available to the public or otherwise part of
the public domain at the time of its disclosure to Service Provider; 

 (c)        became generally available to the public or otherwise part of
the public domain after its disclosure, other than through any act or omission of Service Provider in breach of any obligation of confidentiality; 
  

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 3. 

  (d)        was
disclosed to Service Provider, other than under an obligation of confidentiality, by a third party who had no obligation not to disclose such information to others; or 

 (e)        was independently discovered or developed by Service Provider
without any use of or reference to Proprietary Information. 
 As a qualification to the foregoing exceptions, any combination of features or
disclosures shall not be deemed to fall within the foregoing exclusions solely because certain individual features are published or available to the general public or in the rightful possession of a party unless the combination as a whole falls
within any of the above exceptions. 
 5.3        Third-Party
Information.  Service Provider understands that the Company has received and will in the future receive from third parties certain confidential or proprietary information relating to such third parties (collectively,
“Third-Party Information”), subject to duties on the Company’s part to maintain the confidentiality of such Third-Party Information and to use such Third-Party Information only for certain limited purposes. Service
Provider agrees to hold all Third-Party Information in confidence and not to disclose to anyone (other than personnel of the Company) or to use, except in connection with Service Provider’s performance of the Services, any Third-Party
Information unless expressly authorized in writing by an officer of the Company. 

5.4        Intellectual Property. 

 (a)        Ownership. The Company shall own all right, title and
interest in and to all Materials, the Technology and Company Work Product, including, without limitation, all patent, copyright or other intellectual property rights therein, that is conceived or first reduced to practice by Service Provider, either
solely or jointly with others, in the course of performing the Services (collectively, the “Company Intellectual Property”), and neither this Agreement, nor the provision of the Services hereunder, shall give Service Provider
any right, title or interest in or to any Company Intellectual Property. The Company hereby grants to Service Provider a non-exclusive, worldwide, fully-paid, royalty-free license, without the right to
sublicense, under the Company Intellectual Property solely as necessary or appropriate to perform the Services under this Agreement during the Term. Company shall have the sole right to prosecute any patent application covering any Company
Intellectual Property and to maintain any patents issued thereon. [...***...] of any such patent preparation and filing, prosecuting and maintenance activities in the countries selected by Company. “Materials” means any
chemical or biological materials provided by the Company to Service Provider for use in the Services. “Company Work Product” shall mean any and all results (including data) and products (interim and/or final) of the Services
performed by Service Provider, whether tangible or intangible, including, without limitation, each and every invention (whether or not patentable), discovery, design, drawing, protocol, process, technique, formula, trade secret, device, compound,
substance, material, pharmaceutical, method, software program (including without limitation, object code, source code, flow charts, algorithms and related documentation), listing, routine, manual and specification, whether or not patentable or
copyrightable, that are made, developed, perfected, designed, conceived or first reduced to practice by Service Provider, either solely or jointly with others, in the course of the Services. 

 
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 4. 

 (b)        Assignment. Service Provider hereby: (i) assigns
to the Company all of its right, title and interest in and to all Company Intellectual Property; and (ii) designates the Company as its agent for, and grants to the officers of the Company a power of attorney with full power of substitution
(which power of attorney shall be deemed coupled with an interest) solely for the purpose of, effecting the foregoing assignments from Service Provider to the Company. Service Provider will provide all data, results, supporting documents, copies of
notebook pages, computer files, etc. necessary for Company to prepare and file patent applications and will assist Company in obtaining necessary or required documentation and signatures from Service Provider and/or any of its personnel performing
the Services. Service Provider further agrees to cooperate with and (subject to Company’s reimbursement of Service Provider’s reasonable expenses) provide reasonable assistance to the Company to obtain and from time to time enforce any and
all current or future intellectual property rights covering or relating to Company Intellectual Property in any and all jurisdictions. If any intellectual property rights, including moral rights, in the Company Intellectual Property, cannot as a
matter of law be assigned by Service Provider to the Company as provided in this Section 5.4, then: (x) Service Provider unconditionally and irrevocably waives the enforcement of such rights and all claims and causes of action of any kind
against Company with respect to such rights; and (y) to the extent Service Provider cannot as a matter of law make such waiver, Service Provider unconditionally grants to Company an exclusive, perpetual, irrevocable, worldwide, fully-paid
license to fully utilize such Company Intellectual Property without any restriction, including with the right to sublicense. 

 (c)        The parties hereto acknowledge that Service Provider commenced
activities of the same nature as the Services set forth on Exhibit A prior to the Effective Date on or about February 4, 2014. The parties’ intention was and is for such activities to be treated as Services under this Agreement in
all respects and Service Provider acknowledges and confirms receipt of payment as consideration for such activities from the Company in the amount of $[...***...]. Accordingly, the parties hereby agree that any and all such activities shall be
deemed Services under this Agreement and any all intellectual property to which Service Provider has or may have any right, title or interest that would constitute Company Work Product if such activities had constituted Services hereunder at the
time they were conducted (“Prior Company Work Product”) shall be treated as Company Work Product for all purposes hereunder, including, without limitation, the ownership and assignment provisions of this Section 5.
Service Provider hereby represents and warrants: (A) that the only personnel of Service Provider that have engaged in activities prior to the Effective Date that would have constituted Services hereunder had they been performed during the Term
are listed on Exhibit B hereto, and all such personnel were employees of Service Provider at the time of performing any such activities and have executed proprietary information and inventions agreements or otherwise executed assignments in
favor of Service Provider which effectively assigned all of such personnel’s right, title and interest to all such Prior Company Work Product to Service Provider; and (B) as of immediately prior to the Effective Date, all Prior Company
Work Product contemplated by this Section 5.4(c) is free from any encumbrance, and Service Provider owns all right, title and interest to and all of such Prior Company Work Product, which is free and clear of any lien, encumbrance or, to
Service Provider’s knowledge, any claim of any right, title or interest of any third party. 

5.5        Records. Service Provider shall maintain records of documents,
information, data and materials used or generated in performance of the Services in a professional manner so as to permit Company to review such records in full in accordance with this Section 5.5 without 

 
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 5. 

 
disclosing to Company any third party confidential or proprietary information. Designated representatives of Company shall, upon reasonable notice to Service Provider, have access to and shall be
permitted to review and copy all such records. Following termination of this Agreement, Service Provider shall upon Company’s request deliver to Company one (1) complete copy of such records. 

6.           NO CONFLICTING
OBLIGATION.  Service Provider represents that its entering into this Agreement and its performance of all of the terms of this Agreement (including the performance of the Services pursuant to this Agreement) do not and
will not breach or conflict with any agreement between the Service Provider and any third party, including, without limitation, any agreement between Service Provider and any third party to keep in confidence any proprietary information of another
entity acquired by Service Provider in confidence or in trust prior to the date of this Agreement. Service Provider agrees not to enter into any agreement that conflicts with this Agreement while this Agreement remains in effect. In addition, except
as contemplated by this Agreement, Service Provider will not conduct or participate in, alone or with any third parties, any research or development activities directed to the Technology without the prior written consent of the Company, which
consent shall not be unreasonably withheld. 
  

	7.	     SERVICE PROVIDER REPRESENTATIONS
AND WARRANTIES. 

7.1        Representations and
Warranties.    Service Provider represents, warrants and covenants that Service Provider: (i) will not grant, directly or indirectly, any right or interest in the Company Intellectual Property to any other person;
(ii) has full right, power, and authority to enter into and perform this Agreement without the consent of any third party, including the right to grant all assignments and licenses granted by Service Provider in this Agreement; and
(iii) will comply with all laws, regulations and ordinances applicable to Service Provider’s performance of the Services and its other obligations under this Agreement. 

7.2        Disclaimer of Warranties.    EXCEPT AS
EXPRESSLY SET FORTH IN SECTION 5.4(C), ARTICLE 6 AND SECTION 7.1 ABOVE, SERVICE PROVIDER MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, CONCERNING THE SERVICES, THE COMPANY INTELLECTUAL PROPERTY, OR THE DELIVERABLES,
INCLUDING, WITHOUT LIMITATION, WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT, OR VALIDITY OF ANY CLAIMS OF ANY PATENT OR PATENT APPLICATION ARISING FROM THE SERVICES, WHETHER ISSUED OR PENDING. 

 

	8.	     INDEMNIFICATION. 

8.1        By Service Provider.  Service Provider will defend,
indemnify and hold harmless the Company and its affiliates, directors, officers, employees, consultants and agents (“Company Indemnitees”) from any loss, expense (including reasonable legal counsel fees and expenses), cost,
liability or damages to which any Company Indemnitee may become subject as a result of any claim, demand, action or other proceeding by any third party arising out of a breach of any representation, warranty, covenant or obligation of Service
Provider in this Agreement or any negligence or intentional misconduct by Service Provider or any of its personnel in performing the Services (collectively “Company Loss”), provided that: 

  
 6. 

  (a)        Service
Provider shall not indemnify any Company Indemnitee for any Company Loss to the extent the Company Loss is caused by the gross negligence or willful misconduct of Company; 

 (b)        Service Provider shall not indemnify any Company Indemnitee
for any Company Loss to the extent the Company Loss is caused by a material breach of this Agreement by Company. 

8.2        By Company.  Company agrees to indemnify, defend and
hold harmless Service Provider and its Key Providers, officers, employees and agents (“Service Provider Indemnitees”) from any loss, expense (including reasonable legal counsel fees and expenses), cost, liability or damages
to which any Service Provider Indemnitee may become subject as a result of any claim, demand, action or other proceeding by any third party arising out of Service Provider’s performance of the Services or the use by Company or its designees of
any data, findings, or Company Intellectual Property (collectively “Service Provider Loss”), provided that: 

 (a)        Company shall not indemnify any Service Provider Indemnitee
for any Service Provider Loss to the extent the Service Provider Loss is caused by the negligence or willful misconduct of Service Provider; 

 (b)        Company shall not indemnify any Service Provider Indemnitee
for any Service Provider Loss to the extent the Service Provider Loss is caused by a breach of this Agreement by Service Provider. 

8.3        Procedure.  Any Company Indemnitee or Service
Provider Indemnitee (each, an “Indemnitee”) that intends to claim indemnification under Section 8.1 or 8.2 respectively shall: 

 (a)        as soon as practicable, and in any event within
[...***...], notify the indemnifying party of any known complaint, claim or injury for which it intends to seek indemnification under this Article 8; and 

 (b)        give the indemnifying party sole control of the defense and/or
settlement of any such claim and fully cooperate with the indemnifying party in the defense or settlement of such claim, at the indemnifying party’s expense; provided, however, that no Indemnitee shall be required to
admit fault or responsibility in connection with any settlement. The Indemnitee shall have the right to select and to obtain representation by separate legal counsel [...***...]. 

 (c)        Notwithstanding the foregoing, the indemnifying party shall
have no obligations with respect to any claim under this Article 8 with respect to which the Indemnitee seeking indemnification makes any admission, settlement or other communication regarding such claim without the prior written consent of
indemnifying party, which consent shall not be unreasonably withheld.  

8.4        Disclaimer of Consequential Damages; Limitation of Liability.
NOTWITHSTANDING ANYTHING TO THE CONTRARY IN THIS AGREEMENT: (I) IN NO EVENT SHALL EITHER PARTY OR ANY OF ITS AFFILIATES, OR ANY OF THEIR RESPECTIVE DIRECTORS, OFFICERS, EMPLOYEES, CONSULTANTS OR AGENTS BE 

 
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 7. 

 
LIABLE TO THE OTHER PARTY OR ANY OF ITS AFFILIATES FOR INDIRECT, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND ARISING IN ANY WAY OUT OF THIS AGREEMENT OR THE RIGHTS GRANTED HEREUNDER,
HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, REGARDLESS OF WHETHER SUCH PARTY SHALL BE OR HAS BEEN ADVISED, SHALL HAVE REASON TO KNOW OR IN FACT SHALL KNOW OF THE POSSIBILITY OF THE FOREGOING; PROVIDED, HOWEVER, THAT THE
FOREGOING DISCLAIMER OF CONSEQUENTIAL DAMAGES SHALL NOT BE CONSTRUED TO LIMIT EITHER PARTY’S INDEMNIFICATION OBLIGATIONS UNDER THIS ARTICLE 8, AND (II) IN NO EVENT SHALL SERVICE PROVIDER’S LIABILITY UNDER THIS AGREEMENT EXCEED THE
LESSER OF THE AGGREGATE AMOUNT PAID OR PAYABLE BY COMPANY TO SERVICE PROVIDER UNDER THIS AGREEMENT OR TEN MILLION U.S. DOLLARS ($10,000,000). 
  

	9.	     TERM; TERMINATION. 

9.1        Term.  This Agreement shall remain in effect for a
period of one (1) year following the Effective Date (the “Initial Term”). At the end of such Initial Term, this Agreement shall automatically be renewed for one or more additional periods of one (1) year each (each,
a “Renewal Term”) unless terminated by either party by written notice to the other party delivered at least thirty (30) days prior to the end of the Initial Term or any Renewal Term, as applicable. The Initial Term and
all Renewal Terms, if any, are collectively referred to herein as the “Term”. 

9.2        Termination by Service Provider.  This Agreement may
be terminated, for any reason or no reason at all, by Service Provider at any time following the Effective Date by delivering thirty (30) days’ prior written notice to the Company. 

9.3        Termination by the Company.  This Agreement may be
terminated by the Company: 
  (a)        for any reason or no reason at
all, by the Company at any time following the Effective Date by delivering thirty (30) days’ prior written notice to Service Provider; or 

 (b)        upon Service Provider’s material breach of its
obligations hereunder; provided, however, that the Company shall provide Service Provider written notice of any such claimed breach, describing in reasonable detail the basis for such claim, and Service Provider shall have thirty
(30) days to cure any such breach. 
 9.4        Effect of
Termination.  The provisions of Sections 4, 5, 7, 8, 9.4 and 10 as well as any outstanding payment or reimbursement obligations of the Company, shall survive any termination of this Agreement. Upon any termination of this
Agreement, Service Provider shall promptly deliver to the Company all documents and other materials of any nature pertaining to the Services, together with all documents and other items containing or pertaining to any Proprietary Information,
Third-Party Information or Company Intellectual Property. 
  

	10.	     MISCELLANEOUS. 

10.1      Notices.  All notices required or permitted hereunder shall be
in writing and shall be deemed effectively given: (i) upon personal delivery to the party to be notified; (ii) when sent 

  
 8. 

 
by electronic mail or confirmed facsimile if sent during normal business hours of the recipient, and if not, then on the next business day; (iii) five (5) days after having been sent by
registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All
communications shall be sent to the Company or to Service Provider, as applicable, at the respective addresses set forth on the signature page to this Agreement or at such other address(es) as the Company or Service Provider may designate by ten
(10) days’ advance written notice to the other party hereto. 

10.2      Governing Law.  This Agreement shall be governed
in all respects by the laws of the State of California, without giving effect to principles of conflicts of laws. 

10.3      Successors and Assigns.  The rights and liabilities of the
parties hereto shall bind and inure to the benefit of their respective successors, heirs, executors and administrators, as the case may be; provided, however, that, as the Company has specifically contracted for Service
Provider’s services, which services are unique and personal, Service Provider may not assign or delegate its obligations under this Agreement either in whole or in part to any party without the prior written consent of the Company. The Company
may assign its rights and obligations hereunder to any person or entity who succeeds to all or substantially all of the Company’s operations and who has agreed to be bound by the terms and conditions of this Agreement. Any attempted assignment
in violation of the foregoing terms shall be void. 

10.4      Waiver.  No failure on the part of any party to
exercise any power, right, privilege or remedy under this Agreement, and no delay on the part of any party in exercising any power, right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy
and no single or partial exercise of any such power, right, privilege or remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. No party shall be deemed to have waived any claim arising out of
this Agreement, or any power, right, privilege or remedy under this Agreement, unless the waiver of such claim, power, right, privilege or remedy is expressly set forth in a written instrument duly executed and delivered on behalf of such party, and
any such waiver shall not be applicable or have any effect except in the specific instance in which it is given. 

10.5      Amendments.    This Agreement may not be amended,
modified, altered or supplemented other than by means of a written instrument duly executed and delivered on behalf of all of the parties hereto. 

10.6      Severability.    If one or more provisions of this
Agreement are held to be unenforceable under applicable law, the parties agree to renegotiate such provision in good faith. In the event that the parties cannot reach a mutually agreeable and enforceable replacement in writing for such provision,
then: (i) such provision shall be excluded from this Agreement; (ii) the balance of the Agreement shall be interpreted as if such provision were so excluded; and (iii) the balance of the Agreement shall be enforceable in accordance
with its terms. 
 10.7      Disclaimer.  Except as expressly set
forth in this Agreement (including the Exhibits hereto), NEITHER PARTY MAKES ANY REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, AND EXPRESSLY DISCLAIMS ALL IMPLIED 

  
 9. 

 
WARRANTIES OF TITLE, NON-INFRINGEMENT, MERCHANTABILITY, AND FITNESS FOR A PARTICULAR PURPOSE 

10.8      Entire Agreement.  This Agreement, including the Exhibits,
sets forth the entire understanding of the parties hereto relating to the subject matter hereof and thereof and supersedes all prior agreements and understandings among or between any of the parties relating to the subject matter hereof and thereof.

 10.9      Counterparts; Execution by Facsimile.  This Agreement may
be executed in any number of counterparts, each of which shall be deemed an original and all of which together shall constitute one and the same instrument. The exchange of copies of this Agreement or amendments thereto and of signature pages by
facsimile transmission or by e-mail transmission in portable digital format, or similar format, shall constitute effective execution and delivery of such instrument(s) by the parties and may be used in lieu of
the original Agreement for all purposes. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 10. 

 IN WITNESS WHEREOF, the
parties hereto have executed this SUPPORT SERVICES AGREEMENT as of the Effective Date. 

THE COMPANY: 

SYNTHORX, INC. 

/s/ Jay B. Lichter,
Ph.D.                                 

Jay B. Lichter, Ph.D. 

Interim President and Chief Executive Officer 

SERVICE PROVIDER: 

COI PHARMACEUTICALS, INC. 

/s/ Tighe
Reardon                                     

Tighe Reardon 
 CFO 

  
 [SIGNATURE PAGE TO SUPPORT
SERVICES AGREEMENT] 

 EXHIBIT A 

DESCRIPTION OF SERVICES 

 

							
	 	 	 	 
	
Service
  
	  	 Description of Services

 
	 	  	  	 Quarterly
Rate
  

	
General Administrative

Services
	  	 Services normally associated with the roles of Head of Finance, Sr. Staff
Accountant, Human Resources and Facilities, Information Technology, Financial Analyst, Contracts Administration , Executive Assistant, Accounts Payable, and Receptionist. Such Services will include general administrative services required in the
ordinary course of the Company’s business which shall include, but is not limited to: (i) bookkeeping and accounting services, including the maintenance of books and records of the Company’s financial operations in accordance with
U.S. generally accepted accounting principles; (ii) reasonable management information services to the Company, including coordination of network services and database management services, information technology planning services and procurement
of general hardware and software; (iii) payroll administration and process services; and (iv) overhead items, including office supplies and telecommunications services.

 
	 	 	  	$[...***...]
	
Facilities Support
	  	 Service Provider will make available to the Company up to approximately 8,636
square feet of space in Service Provider’s facilities located at 11099 North Torrey Pines, Suite 290, La Jolla, California 92037. Such space is comprised of laboratory space and office space. Quarterly rate to include all operating expenses
(rent, utilities, office supplies, phone, internet, shred services, janitorial, kitchen supplies, bank charges, insurance, legal, tax and accounting, etc.).
  
	 	 	  	$[...***...]
	
Supplies and

Equipment
	  	 Ordering, prepayment, invoicing and distribution of laboratory supplies and
equipment for use in the R&D Services. Amounts may vary each quarter depending on necessity, with the exact amount to be paid in advance to be set forth in a preliminary invoice provided by Service Provider to the Company (which amount shall
ultimately be subject to further adjustment in accordance with Section 2 hereof).
  
	 	 	  	$[...***...]

  
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Treatment Requested 

 EXHIBIT B 

KEY PROVIDERS 

Jennifer Arthur 
 Fran Senchak

 Abby Beers 
 Michael Garcia

 Curt Robak 
 Lauri Sutro 

Charisse Partridge 
 Jennifer
Vargas 
 Christy SayersEX-10.9

 Exhibit 10.9 

OFFICE SUBLEASE 

11099 North Torrey Pines Road, San Diego, California 

KEY PROVISIONS SUMMARY 

					
	 Sublease Date:
	  	
May 6, 2014

	 Sublandlord:
	  	
COI PHARMACEUTICALS, INC., a Delaware corporation

	 Subtenant:
	  	
SYNTHORX, INC., a Delaware corporation

	 Premises:
	  	
Approximately 8,636 rentable square feet of space located in Suite 200/230 in the Master Property, more particularly shown on the floor plan
attached hereto as Exhibit B

	 Master Property:
	  	
Those certain premises located in the building having a street address of 11099 North Torrey Pines Road, City of San Diego, California and
being more particularly described in the Master Lease

	 Master Landlord:
	  	
HCP TORREY PINES LLC, a Delaware limited liability company

	 Master Lease:
	  	
Standard Multi-Tenant Office Lease – Net, by and between Master Land, as landlord, and Sublandlord, as tenant, dated May 7, 2013,
as amended by that certain Addendum to Lease dated August 22, 2013, as amended by that certain First Amendment to Multi Tenant – Net Office Lease dated August 22, 2013, as amended by that certain Second Amendment to Multi-Tenant
Office Lease – Net dated September 23, 2014, as amended by that certain Third Amendment to Multi-Tenant Office Lease – Net dated September 14, 2015, as amended by that certain Fourth Amendment to Multi-Tenant Office Lease –
Net dated May 6, 2016, as amended by that certain Fifth Amendment to Multi-Tenant Office Lease – Net dated November 2, 2016, for the lease of the Master Property, attached hereto as Exhibit A

	 Notices:
	  	 Sublandlord:
	  	
Subtenant:

	  	 COI PHARMACEUTICALS,
INC.
	  	
SYNTHORX, INC.

	  	 With a copy
to:
	  	
With a copy to:

	  	 Tighe
Reardon
	  	
Jay B. Lichter, PhD

	 Commencement Date:
	  	
The Sublease Date: May 6, 2014

	Rent Commencement Date:	  	
The Sublease Date (Section 3)

May 6, 2014

	 Expiration Date:
	  	
The Expansion Expiration Date as defined in the Master Lease: February 28, 2027

	 Rent:
	  	
24 % of Sublandlord’s Base Rent (as defined in the Master Lease) under the Master Lease (Section 3)

	 Additional Rent:
	  	
23% of Lessee’s Share of Operating Expenses (as defined in the Master Lease) under the Master Lease (Section 3)

	 Rent Payment Address:
	  	
11099 N Torrey Pines Road, Suite 290, La Jolla, CA 92037

	 Permitted Use:
	  	
The Agreed Use (as defined in the Master Lease) under the Master (Section 5)

	 Security Deposit:
	  	
$ - 0 - (Section 15)

	 Brokers:
	  	
Re:align Tenant Strategies, whose commission(s) to be paid by HCP (Section 10)

	 Exhibits:
	  	
Exhibit A – Master Lease

Exhibit B – Floor Plan of Premises

  
  

Page 1 

 OFFICE SUBLEASE AGREEMENT 

THIS SUBLEASE is made and entered into as of the Sublease Date by and between Sublandlord and Subtenant. 

Recitals 

A.        Sublandlord leases from Master Landlord the Master Property pursuant to the
Master Lease. 
 B.        Subtenant desires to sublease from Sublandlord the
Premises pursuant to the terms hereof. 
 NOW, THEREFORE, in consideration of mutual covenants contained herein and
other good and valuable consideration, the receipt and sufficiency of which is acknowledged, Sublandlord does hereby sublease unto Subtenant and Subtenant hereby subleases from Sublandlord the Premises upon the following terms and conditions: 

1.        Master Lease Terms and Conditions. 

1.1    References in the body of this Sublease to a portion of the Key Provisions Summary (e.g.,
the defined terms in the left-hand column of the Key Provisions Summary) shall be deemed and construed to incorporate all the terms provided under each such referenced portion of the Key Provisions Summary. References in the Key Provisions Summary
to a portion of the body of this Sublease (e.g., Section references in the right-hand column of the Key Provisions Summary) shall be deemed and construed to incorporate all the terms provided under each such referenced portion of the body of the
Sublease. Notwithstanding anything set forth above, if there is any inconsistency between the Key Provisions Summary and another portion of this Sublease, the terms of the Key Provisions Summary shall control. 

1.2    Except as set forth herein, this Sublease is made upon, and shall be subject and subordinate
to, all of the terms, covenants and conditions of the Master Lease and all mortgages, leases and other documents to which the Master Lease is or may hereafter become subject and subordinate. Subtenant shall, upon request, execute certificates
reasonably requested to confirm such subordination. 
 1.3    Subtenant hereby covenants and
agrees (a) to assume, faithfully perform, observe and be bound by all of the terms, covenants, and conditions required to be performed by or on the part of tenant under the Master Lease related to the Premises, all of which shall constitute the
terms of this Sublease, except to the extent such terms are inconsistent with the terms of this Sublease, in which event the terms of this Sublease shall prevail; (b) to indemnify, protect, defend and hold Sublandlord harmless from and against
any and all liabilities, penalties, demands and other costs and expenses (including, without limitation, reasonable attorneys’ fees) incurred under or pursuant to the Master Lease by reason of Subtenant’s failure to fully comply with any
and all of the duties, covenants and obligations of Sublandlord under and pursuant thereto which are required to be performed by tenant pursuant to the terms of the Master Lease; (c) that any default by Master Landlord shall not affect this
Sublease or waive or defer the performance of any of Subtenant’s obligations hereunder; (d) that Subtenant shall not do or cause to be done or suffer or permit any act to be done which would or might cause the Master Lease, or the rights
of Sublandlord as tenant under the Master Lease to be endangered, canceled, terminated, forfeited or surrendered, or which would or might cause Sublandlord to be in default thereunder or liable for any damage, claim or penalty; and (e) to
obtain Sublandlord’s consent whenever Master Landlord’s consent is needed under the Master Lease. 

1.4    Subtenant agrees, as an express inducement for Sublandlord’s execution of this
Sublease, that if there is any conflict between the provisions of this Sublease and the provisions of the Master 

  
  

Page 2 

 
Lease which would permit Subtenant to do or cause to be done or suffer or permit anything to be done which is prohibited by the Master Lease, then the provisions of the Master Lease shall
prevail. Subtenant acknowledges that Sublandlord does not covenant or agree to do or perform any obligations undertaken or assumed by the Master Landlord under the Master Lease and that Master Landlord has responsibility for providing services and
utilities under the terms of the Master Lease. Sublandlord agrees to assist Subtenant in securing the performance of any responsibility of Master Landlord under the terms of the Master Lease. Sublandlord shall maintain the Master Lease in full force
and effect during the Sublease Term provided Sublandlord shall not be liable to Subtenant for any early termination of or default under the Master Lease which is not due to the gross negligence or willful misconduct of Sublandlord. 

2.        Sublease Term. The term of this Sublease shall
begin on the Commencement Date and shall continue until the Expiration Date (the “Sublease Term”). 

3.        Rent. 

3.1        Subtenant shall pay Sublandlord the Rent in twelve (12) equal
monthly installments, in advance, not later than the first day of each calendar month, without notice, deduction, or offset, commencing on the Rent Commencement Date and continuing through the Sublease Term. If the Rent Commencement Date is not the
first day of a calendar month, Rent shall be pro-rated for such short-month and paid not later than the Rent Commencement Date. 

3.2        Checks for all Rent shall be made payable to Sublandlord and mailed
or delivered to the address set forth in the Key Provisions Summary or to such other address as Sublandlord may designate to Subtenant in writing. To defray administrative and handling expenses, Subtenant agrees to pay an additional charge of Fifty
and No/100 Dollars ($50) for each returned check. If any payment of Rent is not received by Sublandlord when due, then Subtenant shall pay Sublandlord the greater of (i) five percent (5%) of the late Rent; or (ii) Two Hundred Fifty and
No/00 Dollars ($250.00). In addition, if any payment of Rent is not received within ten (10) days of when due, such late Rent shall bear interest at the lesser of eighteen percent (18%) per annum, compounded monthly, or the maximum rate
permitted under law (“Interest”), from the due date of such Rent until such Rent and all Interest accrued thereon is paid in full. Subtenant acknowledges that the aforementioned administrative charge, late charge and Interest
are in addition to Sublandlord’s other rights and remedies available under this Sublease, at law or in equity, and that such administrative charge, late charge and Interest shall in no way limit Sublandlord’s other rights and remedies. If
Sublandlord shall at any time accept any such Rent or other sums after the same shall become due and payable, such acceptance shall not excuse a delay upon subsequent occasions, or constitute or be construed as a waiver of any of Sublandlord’s
rights hereunder, at law or in equity. 
 3.3        Sublandlord’s Base
Rent (as defined in the Master Lease) under the Master Lease is subject to annual increases as set forth in the Master Lease. 

3.4        With each payment of Rent, Subtenant shall pay 23% of Lessee’s
Share of Operating Expenses (as defined in the Master Lease) under the Master Lease for the upcoming month. 

4.        Insurance. Subtenant shall, at its sole cost and
expense, maintain throughout the Sublease Term, any insurance coverage required to be maintained by Sublandlord under the Master Lease, pursuant to the terms and conditions of the Master Lease, with a company authorized to transact business in the
jurisdiction where the Premises is located and otherwise in accordance with the terms of the Master Lease. Sublandlord and Master Landlord shall be named as additional insureds under such insurance. Subtenant shall indemnify and save harmless
Sublandlord and Master Landlord from any claim or loss by reason of an accident or damage to any person or property happening in the Premises. Subtenant shall provide Sublandlord and Master Landlord with certificates of insurance evidencing the
insurance be maintained by Subtenant herein. Subtenant 

  
  

Page 3 

 
further agrees to give thirty (30) days advance written notice of any cancellation or reduction of insurance under any such policy. Neither Sublandlord nor Subtenant shall be liable to the
other party for damages to the Master Property or the Premises, the improvements located thereon or the contents thereof, to the extent that such liability is coverable by a policy of insurance required to be maintained, or actually maintained, by
the damaged party. Sublandlord and Subtenant hereby grant to one another on behalf of any insurer providing insurance to either covering the Master Property or the Premises, the improvements located thereon or the contents thereof, a waiver of any
right of subrogation any such insurer of one party may acquire against the other by virtue of payment of any loss under any such insurance. The foregoing provision shall be of no force or effect to the extent its existence or enforceability would
adversely affect the enforceability, validity and/or collectability of any insurance coverage claimed by either party provided that both parties agree to obtain any insurance endorsements which may be available at nominal cost if such endorsements
would permit the effectiveness of this provision under circumstances where it would otherwise be ineffective. If a party is unable to obtain such endorsement, it shall immediately notify the other of this inability. In the absence of such
notification, each party shall be deemed to have obtained such waiver of subrogation. 

5.        Use and Compliance With Laws. Subtenant shall
(a) use the Premises for the Permitted Use only and for no other purpose; (b) not conduct on the Premises nor permit to be conducted on the Premises any business which is in violation of federal law, the laws of the State in which the
Premises is located or any law or ordinance of any political subdivision having jurisdiction over the Premises: (c) maintain the Premises in compliance with “tenant’s” maintenance requirements under the Master Lease; and
(d) not, without compliance with applicable rules, regulations and ordinances, generate, store, treat or dispose of any hazardous materials (as defined in the Master Lease) or otherwise breach any of the representations regarding hazardous
materials contained in the Master Lease or this Sublease and shall promptly notify Sublandlord of any written allegation of non-compliance received by Subtenant. Without limiting any other indemnification set
forth in this Sublease, Subtenant shall indemnify, protect, defend and hold Sublandlord and Master Landlord harmless from and against any and all damages, liabilities, judgments, costs, claims, liens, expenses, penalties, suits, demands, actions,
fines, and all costs and expenses thereof (including, without limitation, reasonable attorneys’ and consultants’ fees) arising out of or involving any hazardous materials introduced to the Premises by Subtenant or at Subtenant’s
direction or any other violation of any applicable environmental laws by Subtenant or its agents. This provision shall survive the expiration or earlier termination of the Sublease Term. No termination, cancellation or release agreement entered into
by Sublandlord or Master Landlord and Subtenant shall release Subtenant from its obligations under this Sublease with respect to all applicable environmental laws unless specifically so agreed by Sublandlord and Master Landlord in writing at the
time of such agreement. This provision shall survive the expiration or early termination of this Sublease. 

6.        Alterations. Subtenant has examined the Premises
and accepts the Premises in an “AS IS” “WHERE IS” “WITH ALL FAULTS” condition, and Subtenant acknowledges and agrees that neither Sublandlord nor any of Sublandlord’s agents, employees or
representatives have made any representation or warranty, either express or implied, with respect to the Premises or the use thereof by Subtenant. Subtenant shall not make any alterations to the Premises without Sublandlord’s and Master
Landlord’s, as may be required, prior written consent. If any alterations are permitted, Subtenant shall comply with all requirements of the Master Lease with respect to such alterations, including, but not limited to, mechanics’ liens and
bonding. Any alterations made, other than the installation of Subtenant’s personal property, shall remain on and be surrendered with the Premises on the expiration or earlier termination of the Sublease Term, unless such alterations are
required to be removed pursuant to the terms of this Sublease or Sublandlord requires Subtenant to remove such alterations, in which case Subtenant shall, at its own cost, remove such alterations and repair any damage caused by such removal. 

7.        Indemnification. Subtenant shall indemnify,
protect, defend and hold Sublandlord and Master Landlord harmless from and against any and all damages, liabilities, judgments, costs, claims, liens, expenses, penalties, suits, demands, actions, fines, and all costs and expenses thereof (including,
without limitation, 

  
  

Page 4 

 
reasonable attorneys’ and consultants’ fees) arising out of or involving the use or occupancy of the Premises by Subtenant, its agents, contractors, employees, invitees, licensees,
servants, subcontractors or subtenants, except to the extent caused by the gross negligence or willful misconduct of Sublandlord. 

8.        Default. The occurrence of one or more of the
following events (herein “Events of Default”) shall constitute a default by Subtenant and a breach of this Sublease: (a) the filing of a petition by Subtenant for adjudication as bankrupt, the involuntary adjudication of
Subtenant as bankrupt or the voluntary reorganization of Subtenant pursuant to the United States Bankruptcy Code; (b) the appointment of a receiver for Subtenant; (c) the making by Subtenant of any assignment for the benefit of creditors;
(d) the failure to pay rent within three (3) days after same becomes due or the failure to maintain the required insurance coverages to be maintained by Subtenant hereunder; (e) a default in the performance of any other covenant or
condition of this Sublease on the part of Subtenant not cured within five (5) days of Sublandlord’s notice thereof (except no notice shall be required for Sublandlord to commence to cure Subtenant’s default in the event of an
emergency or if required under the Master Lease); and (f) any other act or omission which would constitute a default under the terms of the Master Lease. 

9.        Sublandlord’s Remedies On Default By
Subtenant. Upon the occurrence of an Event of Default, Sublandlord shall have the right to terminate this Sublease and/or Subtenant’s right to possession of the Premises at any time and reenter the Premises. In addition,
Sublandlord shall have the right to pursue any and all other remedies available at law and in equity to recover from Subtenant all amounts then due or thereafter accruing and such other damages as are caused by Subtenant’s Event of Default. No
course of dealing between Sublandlord and Subtenant or any delay on the part of Sublandlord in exercising any rights Sublandlord may have under this Sublease shall operate as a waiver of any of the rights of Sublandlord hereunder nor shall any
waiver or prior default operate as a waiver of any subsequent default. In exercising its rights and remedies under this Sublease, Sublandlord shall be entitled to recover from Subtenant all costs incurred, including, without limitation, reasonable
attorneys’ fees. 
 10.        Brokers. Sublandlord
and Subtenant warrant that they have not used any broker other than Broker, if any, and each party agrees to indemnify, protect, defend and hold each other harmless from and against any and all damages, liabilities, judgments, costs, claims, liens,
expenses, penalties, suits, demands, actions, fines, and all costs and expenses thereof (including, without limitation, reasonable attorneys’ and consultants’ fees) for brokerage commissions arising out of or involving each other’s
actions in connection with this Sublease, including the payment of any commission or any other fee or charge due to any other broker having a claim through such party. 

11.        Assignment and Subletting. Subtenant shall not
further sublet all or any portion of the Premises to others or assign or encumber this Sublease without the prior written consent of Sublandlord. Consent by Sublandlord to one assignment or subletting shall not destroy or operate as a waiver of the
prohibitions contained in this paragraph or in the Master Lease as to future assignments or subleases, and all such later assignments or subleases shall be made only with the prior written consent of Sublandlord. In the event an assignment or
encumbrance of this Sublease or subletting of the Premises or any part thereof is made by Subtenant, Subtenant shall remain liable to Sublandlord for payment of all rent provided for hereunder and for the faithful performance of all the covenants
and conditions contained herein to the same extent as if this Sublease had not been assigned or encumbered or the Premises sublet. If Subtenant sublets the Premises at a rental that exceeds all rentals to be paid to Sublandlord hereunder, Subtenant
shall pay over any such excess to Sublandlord. Subtenant shall pay to Sublandlord a fee of $1,500 for Sublandlord’s review of a request for consent to assign, encumber, or sublet. 

12.        Entry. Master Landlord and Sublandlord shall
have the same rights to enter into the Premises as are provided to Master Landlord to enter the Master Property in the Master Lease. 

  
  

Page 5 

 13.        Holding
Over. Subtenant shall have no right to occupy the Premises or any portion thereof after the expiration of this Sublease or after termination of this Sublease or of Subtenant’s right to possession in consequence of an Event of
Default hereunder. If Subtenant or any party claiming by, through or under Subtenant holds over, Sublandlord may exercise any and all remedies available to it at law or in equity to recover possession of the Premises, and to recover damages,
including, without limitation, damages payable by Sublandlord to Master Landlord by reason of such holdover. For each and every month or partial month that Subtenant or any party claiming by, through or under Subtenant remains in occupancy of all or
any portion of the Premises after the expiration of this Sublease or after termination of this Sublease or Subtenant’s right to possession, Subtenant shall pay, as minimum damages and not as a penalty, monthly rent at a rate equal to double the
rate of monthly Rent and Additional Rent payable by Subtenant hereunder immediately prior to the expiration or other termination of this Sublease or of Subtenant’s right of possession. The acceptance by Sublandlord of any lesser sum shall be
construed as payment on account and not in satisfaction of damages for such holding over. 

14.        Limitation of Liability. Subtenant agrees that
Subtenant shall look solely to the interest of Sublandlord in the Premises for the collection of any judgment requiring the payment of money by Sublandlord for any default or breach under this Sublease. 

15.        Security Deposit. As an express condition of
the Sublease, Subtenant shall deposit with Sublandlord the Security Deposit, which shall be held during the Sublease Term by Sublandlord to guarantee the faithful performance by Subtenant of its obligations as provided in this Sublease. The Security
Deposit or any portion thereof may be applied to the curing of any default that may then exist, without prejudice to any other remedy or remedies which Sublandlord may have on account thereof, and upon such application Subtenant shall pay
Sublandlord on demand the amount so applied which shall be added to the Security Deposit so the same may be restored to its original amount. Unless prohibited by law, Sublandlord or its successor may commingle the Security Deposit with its other
funds. Upon termination of this Sublease, and provided Subtenant is not in default hereunder and has performed all of its obligations under this Sublease, Sublandlord shall return the remainder of Security Deposit, without any interest thereon, to
Subtenant. Subtenant covenants and agrees that it will not assign, pledge, hypothecate, mortgage or otherwise encumber the aforementioned security during the Sublease Term. 

16.        Notice. 

16.1    Written Notice; Delivery Methods. Each party giving or making any
notice, request, demand, consent, approval, or other communication (each, a “Notice” (but sometimes “notice”)) pursuant to this Sublease shall: (i) give the Notice in writing; (ii) cause the
Notice to be signed by an authorized officer of the sending party; and (iii) use one of the following methods of delivery, each of which for purposes of this Sublease is a writing: (a) personal delivery; (b) Registered or Certified
Mail, in each case, return receipt requested and postage prepaid; (c) nationally recognized overnight courier, with all fees prepaid; or (d) facsimile (but only if a party’s fax number is included in its notice address in the Key
Provisions Summary). 
 16.2    Addresses. Each party giving a Notice shall
address the Notice to the appropriate person at the receiving party (the “Addressee”) at the addresses listed in the Notice Addresses section of the Key Provisions Summary or to another Addressee or at another address as
designated by a party in a Notice pursuant to this Section 16. 

16.3    Effectiveness of a Notice. Except as provided elsewhere in this Sublease, a Notice
is effective only if the party giving the Notice has complied with Sections 16.1 and 16.2 above and if the Addressee has received the Notice. A Notice is deemed to have been received as follows: (i) if a Notice is delivered in
person, or sent by Registered or Certified Mail, or nationally recognized overnight courier, upon receipt as indicated by the date on the signed receipt; (ii) if a Notice is sent by facsimile, upon receipt by the

  
  

Page 6 

 
party giving the Notice of an acknowledgment or transmission report generated by the machine from which the facsimile was sent indicating that the facsimile was sent in its entirety to the
Addressee’s facsimile number; and (iii) if the Addressee rejects or otherwise refuses to accept the Notice, or if the Notice cannot be delivered because of a change in address for which no Notice was given, then upon the rejection,
refusal, or inability to deliver the Notice. In addition, if a Notice is sent by facsimile, the party sending the Notice shall also send a confirmation copy of the Notice by one of the methods set forth in Section 16.3(i)
above. 
 16.4    Delivery Time of Notice. Notwithstanding the foregoing,
if any Notice is received after 5:00 p.m. on a Business Day where the Addressee is located, or on a day that is not a Business Day where the Addressee is located, then the Notice is deemed received at 9:00 a.m. on the next Business Day where the
Addressee is located. Each party’s attorney is authorized to give any Notice pursuant to this Sublease on behalf of such attorney’s client. 

17.        Jurisdiction. The parties hereto agree that
this Sublease and the enforcement hereof shall be construed in accordance with and governed by the laws of the State in which the Premises is located and that any action brought under this Sublease shall be brought in the state courts. 

18.        Corporate Authority. Subtenant and each person
executing this Sublease on behalf of Subtenant represents and warrants that Subtenant is validly existing under the laws of their state of domicile and that Subtenant has full right and authority to enter into this Sublease and to perform all of
Subtenant’s obligations hereunder. 
 19.        Integration and
Binding Effect. The entire agreement between Sublandlord and Subtenant is contained in the provisions of this Sublease and any stipulations, representations, promises or agreements, written or oral made prior to or contemporaneous
with this Sublease shall have no legal effect unless contained herein. In the event Sublandlord retains an attorney to enforce provisions of this Sublease, Sublandlord shall be entitled to recover, in addition to all other remedies available at law
or in equity, its reasonable attorneys’ fees from the Subtenant. Titles to the paragraphs of this Sublease shall be ignored when interpreting this Sublease. This Sublease shall be binding upon and inure to the benefit of the parties hereto,
their respective heirs, successors and assigns. Any amendments to this Sublease must be made in writing and executed by the party to be charged with such amendment. 

20.        Certification. Subtenant certifies that:
(i) it is not acting, directly or indirectly, for or on behalf of any person, group, entity, or nation named by any Executive Order or by the U.S. Treasury Department as a terrorist, a “Specially Designated National and Blocked
Person,” or any other banned or blocked person, entity, nation, or transaction pursuant to any law, order, rule, or regulation that is enforced or administered by the Office of Foreign Assets control; and (ii) it is not engaged in this
transaction directly or indirectly on behalf of, or instigating or facilitating this transaction directly or indirectly on behalf of, any such person, group, entity, or nation. Tenant shall indemnify, defend, and hold harmless Sublandlord from and
against any and all claims, damages, losses, liabilities, costs, expenses, and fines, including but not limited to reasonable attorneys’ fees, witness fees, and court costs actually incurred, arising out of or related to any breach of the
foregoing certification. 
 21.        Attorneys’
Fees. In the event of any litigation related to this Sublease, whether to enforce its terms, recover for default, or otherwise, if either party receives a judgment, settlement, or award in its favor (the “Receiving
Party”) against the other party (the “Paying Party”) in such litigation, the Paying Party will pay upon demand all of the Receiving Party’s costs, charges, and expenses (including but not limited to
reasonable attorneys’ fees, court costs, and expert witness fees) arising out of such litigation (including the costs of any appeal related thereto); provided, however, that if prior to commencement of a trial in the litigation the Paying Party
offers to pay an amount equal to or in excess of such judgment, settlement, or award, the Receiving Party shall not be entitled to any such costs, charges, expenses, or attorneys’ fees. 

  
  

Page 7 

 IN WITNESS WHEREOF, the parties hereto have executed this Office
Sublease Agreement as of the day and year first above written. 
  

	
	 Sublandlord

	
	 COI PHARMACEUTICALS, INC.,

a Delaware corporation

	
	 By: /s/ Tighe
Reardon                                    

	
	 Print Name: Tighe Reardon

	
	 Title: Chief Financial Officer

	
	 Date: August 28,
2017                                  

	
	 Subtenant

	
	SYNTHORX, INC.
	 A Delaware corporation

	
	 By: /s/ Jay B. Lichter,
PhD                          

	
	 Print Name: Jay B. Lichter, PhD

	
	 Title: President & Chief Executive Officer

	
	 Date: August 28, 2017

  
  

Page 8 

 EXHIBIT A 

MASTER LEASE 

 EXHIBIT B 

FLOOR PLAN

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