Document:

Exhibit 10.2

                                                                  EXECUTION COPY

                       AMENDMENT NO. 1 TO CREDIT AGREEMENT
                                       AND
                      AMENDMENT NO. 1 TO GUARANTY AGREEMENT

            THIS AMENDMENT NO. 1 TO CREDIT AGREEMENT AND AMENDMENT NO. 1 TO
GUARANTY AGREEMENT (this "Amendment") is being executed and delivered as of
March 21, 2005 by and among Watts Water Technologies, Inc., a Delaware
corporation (the "Company"), Watts Industries Europe B.V., a private company
with limited liability organized under the laws of The Netherlands (the "Initial
Designated Borrower"), each of the Subsidiary Guarantors named as signatories
hereto, the several financial institutions from time to time party to the Credit
Agreement referred to and defined below (collectively, the "Lenders") and Bank
of America, N.A. ("Bank of America"), as administrative agent for the Lenders
(in such capacity, the "Administrative Agent"). Undefined capitalized terms used
herein shall have the meanings ascribed to such terms in such Credit Agreement
as defined below.

                                   W I T N E S S E T H:

            WHEREAS, the Company, the Initial Designated Borrower, the Lenders
and the Administrative Agent have entered into that certain Credit Agreement
dated as of September 23, 2004 (the "Credit Agreement"), pursuant to which,
among other things, the Lenders have agreed to provide, subject to the terms and
conditions contained therein, certain loans and other financial accommodations
to or for the benefit of the Company and the Initial Designated Borrower;

            WHEREAS, the Company, the Initial Designated Borrower and certain
Subsidiaries of the Company have executed that certain Guaranty Agreement, dated
as of September 23, 2004 (as amended, restated, supplemented or otherwise
modified from time to time, the "Guaranty Agreement"), in favor of the
Administrative Agent;

            WHEREAS, pursuant to Section 2.14(c) of the Credit Agreement, the
Initial Designated Borrower has (i) agreed to be jointly and severally liable
for the Obligations of the Company and each other Designated Borrower and (ii)
executed the Guaranty Agreement, pursuant to which the Initial Designated
Borrower provided an unconditional guaranty of the Obligations of the Company
and each other Designated Borrower;

            WHEREAS, pursuant to Section 6.15 of the Credit Agreement, Watts
Cazzaniga S.p.A., a private company with limited liability organized under the
laws of Italy ("Watts Cazzaniga"), Watts Londa S.p.A., a private company with
limited liability organized under the laws of Italy ("Watts Londa"), Watts
Intermes S.r.l., a private company with limited liability organized under the
laws of Italy ("Watts Intermes"), and Giuliani Anello S.r.l., a private company
with limited liability organized under the laws of Italy ("Giuliani Anello" and,
collectively with Watts Cazzaniga, Watts Londa and Watts Intermes, the "Foreign
Subsidiary Guarantors"), executed Supplements to the Guaranty Agreement, dated
as of November 19, 2004, pursuant to which the Foreign Subsidiary Guarantors
provided an unconditional guaranty of the Obligations of the Company and the
Designated Borrowers; and
<PAGE>

            WHEREAS, the Company, the Initial Designated Borrower and the
Foreign Subsidiary Guarantors have requested that that Lenders and the
Administrative Agent, and subject to the terms and conditions set forth herein,
the Lenders and the Administrative Agent have agreed to, (i) amend the Credit
Agreement to provide that Designated Borrowers that are Foreign Subsidiaries of
the Company (such Designated Borrowers, "Foreign Designated Borrowers") shall be
required to deliver an unconditional guaranty only of the Obligations of Foreign
Designated Borrowers and (ii) amend the Guaranty Agreement to provide that
Foreign Subsidiaries of the Company party thereto shall provide an unconditional
guaranty only of Obligations of Foreign Designated Borrowers;

            NOW, THEREFORE, in consideration of the foregoing premises, the
terms and conditions stated herein and other valuable consideration, the receipt
and sufficiency of which are hereby acknowledged by the Company, the Initial
Designated Borrower, the Subsidiary Guarantors, the Lenders and the
Administrative Agent, such parties hereby agree as follows:

            1. Amendment to Credit Agreement. Subject to the satisfaction of
each of the conditions set forth in Paragraph 3 of this Amendment, the Credit
Agreement is hereby amended as follows:

            (a) The Credit Agreement is hereby amended to delete the first
sentence of Section 2.03(i) thereof in its entirety and to replace such sentence
with the following sentence:

      Each Borrower shall pay to the Administrative Agent for the account of
      each Lender in accordance with its Applicable Percentage, in Dollars, a
      Letter of Credit fee (the "Letter of Credit Fee") for each Letter of
      Credit issued at the request of such Borrower equal to the Applicable Rate
      times the Dollar Equivalent of the daily amount available to be drawn
      under such Letter of Credit.

            (b) Section 2.03(j) of the Credit Agreement is hereby amended to (i)
delete therefrom the phrase: "The Borrowers shall, jointly and severally, pay
directly to the L/C Issuer for its own account, in Dollars, a fronting fee with
respect to each Letter of Credit" and insert therefor the following phrase:
"Each Borrower shall pay directly to the L/C Issuer for its own account, in
Dollars, a fronting fee with respect to each Letter of Credit issued at the
request of such Borrower" and (ii) delete therefrom the phrase "In addition, the
Borrowers shall, jointly and severally, pay directly to the L/C Issuer for its
own account, in Dollars" and insert therefor the following phrase: "In addition,
each Borrower shall pay directly to the L/C Issuer for its own account, in
Dollars, with respect to each Letter of Credit issued at the request of such
Borrower".

            (c) The Credit Agreement is hereby amended to delete Section 2.14(c)
thereof in its entirety and to replace such provision with the following
provision:

            "(c) Concurrently with the delivery of each Designated Borrower
      Request and Assumption Agreement, the related Applicant Borrower shall
      execute and deliver to the Administrative Agent a counterpart of the
      Guaranty Agreement or such other document as the Administrative Agent
      shall deem appropriate in order for such Subsidiary to provide an
      unconditional guaranty of the Obligations of each other Borrower (in the
      case of any Designated Borrower that is a Domestic Subsidiary of the
      Company) or each other Foreign Designated Borrower (in the case of any
      Designated Borrower that is a Foreign Subsidiary of the Company), in form,
      content and scope reasonably satisfactory to the Administrative Agent."

                                       2
<PAGE>

            (d) Section 6.15 of the Credit Agreement is hereby amended to delete
      therefrom the phrase "unconditional guaranty of the Obligations of the
      Borrowers" and insert therefor the following phrase: "unconditional
      guaranty of the Obligations of the each Designated Borrower that is a
      Foreign Subsidiary of the Company".

            2. Amendments to Guaranty Agreement. Subject to the satisfaction of
      each of the conditions set forth in Paragraph 3 of this Amendment, the
      Guaranty Agreement is hereby amended as follows:

            (a) The Guaranty Agreement is hereby amended to delete the last
preliminary statement thereto in its entirety and to replace such statement with
the following statement:

            "WHEREAS, in order to induce Administrative Agent and Lenders to
      enter into the Credit Agreement and other Loan Documents and to induce
      Lenders to make the Loans and other financial accommodations as provided
      for in the Credit Agreement, (i) the Company, each Designated Borrower
      that is a Domestic Subsidiary of the Company (each such Designated
      Borrower, a "Domestic Designated Borrower") and each Subsidiary Guarantor
      that is a Domestic Subsidiary of the Company (such Subsidiary Guarantors,
      together with the Company and the Domestic Designated Borrowers, the
      "Domestic Guarantors") have agreed to guarantee payment of the Obligations
      of all of the Borrowers and (ii) each Designated Borrower that is a
      Foreign Subsidiary of the Company (each such Designated Borrower, a
      "Foreign Designated Borrower") and each Subsidiary Guarantor that is a
      Foreign Subsidiary of the Company (such Subsidiary Guarantors, together
      with the Foreign Designated Borrowers, the "Foreign Guarantors") have
      agreed to guarantee payment of the Obligations of all of the Foreign
      Designated Borrowers;"

            (b) Section 1 of the Guaranty Agreement is hereby amended to delete
the first sentence thereof in its entirety and to replace such sentence with the
following provision:

      "Each Domestic Guarantor hereby, jointly and severally, absolutely and
      unconditionally guarantees, as a guarantee of payment and not merely as a
      guarantee of collection, prompt payment when due, whether at stated
      maturity, upon acceleration or otherwise, and at all times thereafter, of
      any and all existing and future Obligations of all of the Borrowers to the
      Administrative Agent, the Lenders, the L/C Issuer and the Affiliates of
      the foregoing to whom Obligations are owed, and the respective successors,
      endorsees, transferees and assigns of each of the foregoing (each a
      "Holder of Obligations" and collectively the "Holders of Obligations")
      (including all renewals, extensions and modifications thereof and all
      costs, reasonable attorneys' fees and expenses incurred by the Holders of
      Obligations in connection with the collection or enforcement thereof)
      (collectively, the "Guaranteed Obligations"). Each Foreign Guarantor
      hereby, jointly and severally, absolutely and unconditionally guarantees,

                                       3
<PAGE>

      as a guarantee of payment and not merely as a guarantee of collection,
      prompt payment when due, whether at stated maturity, upon acceleration or
      otherwise, and at all times thereafter, of any and all existing and future
      Obligations of all of the Foreign Designated Borrowers to the Holders of
      Obligations (including all renewals, extensions and modifications thereof
      and all costs, reasonable attorneys' fees and expenses incurred by the
      Holders of Obligations in connection with the collection or enforcement
      thereof) (collectively, the "Guaranteed Foreign Obligations"; it being
      understood that all references to the "Guaranteed Obligations" herein
      (except in the first sentence of Section 10, in which instance the
      reference to "Guaranteed Obligations" shall refer to all existing and
      future Obligations of all of the Borrowers to the Holders of Obligations)
      shall, in the case of any Foreign Guarantor, refer only to the Guaranteed
      Foreign Obligations)."

            (c) Section 2 of the Guaranty Agreement is hereby amended to insert
at the end of the last sentence thereof the following proviso: "; provided, that
no Foreign Guarantor shall be liable for any indemnity for (or otherwise with
respect to) any taxes paid by a Holder of Obligations in respect of a payment
received from any Domestic Guarantor".

            (d) Section 12 of the Guaranty Agreement is hereby amended to insert
at the end of the first sentence thereof the following proviso: "; provided,
that no Foreign Guarantor shall be liable for any expenses in any way related to
the enforcement or protection of the rights of the Holders of Obligations
hereunder against any Domestic Guarantor".

            2. Effectiveness of this Amendment; Condition Precedent. The
provisions of Paragraphs 1 and 2 of this Amendment shall be deemed to have
become effective as of the date of this Amendment, but such effectiveness shall
be expressly conditioned upon the receipt by the Administrative Agent of an
originally-executed counterpart of this Amendment executed and delivered by duly
authorized officers of the Company, the Initial Designated Borrower, each
Subsidiary Guarantor, each Lender and the Administrative Agent.

            3. Representations and Warranties. The Company, the Initial
Designated Borrower and each Subsidiary Guarantor hereby represents and warrants
that (i) this Amendment constitutes its legal, valid and binding obligation,
enforceable against each such party in accordance with its terms, (ii) there is
no consent, approval or other requirement known to such Loan Party which could
reasonably be expected to impair or materially delay such Loan Party's ability
to perform its obligations under this Amendment or the Credit Agreement or
Guaranty Agreement as proposed to be amended hereby and (iii) after giving
effect to the provisions of Paragraphs 1 and 2 of this Amendment, no Event of
Default will be continuing.

            4. Reaffirmation, Ratification and Acknowledgment; Reservation. The
Company, the Initial Designated Borrower and each Subsidiary Guarantor hereby
(a) ratifies and reaffirms all of its payment and performance obligations,
contingent or otherwise, and each grant of security interests and liens in favor
of the Administrative Agent, under each Loan Document to which it is a party,
(b) agrees and acknowledges that such ratification and reaffirmation is not a
condition to the continued effectiveness of such Loan Documents, and (c) agrees
that neither such ratification and reaffirmation, nor the Administrative Agent's
or any Lender's solicitation of such ratification and reaffirmation, constitutes
a course of dealing giving rise to any obligation or condition requiring a

                                       4
<PAGE>

similar or any other ratification or reaffirmation from the Company, the Initial
Designated Borrower or such Subsidiary Guarantors with respect to any subsequent
modifications to the Credit Agreement or the other Loan Documents. The Credit
Agreement and the Guaranty Agreement are in all respects ratified and confirmed.
Each of the Loan Documents shall remain in full force and effect and is hereby
ratified and confirmed. Neither the execution, delivery nor effectiveness of
this Amendment shall operate as a waiver of any right, power or remedy of the
Administrative Agent or the Lenders, or of any Default or Event of Default
(whether or not known to the Administrative Agent or the Lenders), under any of
the Loan Documents, all of which rights, powers and remedies, with respect to
any such Default or Event of Default or otherwise, are hereby expressly reserved
by the Administrative Agent and the Lenders. This Amendment shall constitute a
Loan Document for purposes of the Credit Agreement.

            5. Effect on the Credit Agreement and the Guaranty Agreement. Upon
the effectiveness of this Amendment, on and after the date hereof, (i) each
reference in the Credit Agreement to "this Agreement," "hereunder," "hereof,"
"herein" or words of like import shall mean and be a reference to the Credit
Agreement, as amended and modified hereby and (ii) each reference in the
Guaranty Agreement to "this Guaranty," "hereunder," "hereof," "herein" or words
of like import shall mean and be a reference to the Guaranty Agreement, as
amended and modified hereby.

            6. Governing Law. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED
IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.

            7. Administrative Agent's Expenses. The Company hereby agrees to
promptly reimburse the Administrative Agent for all of the reasonable
out-of-pocket expenses, including, without limitation, attorneys' and
paralegals' fees, it has heretofore or hereafter incurred or incurs in
connection with the preparation, negotiation and execution of this Amendment.

            8. Counterparts. This Amendment may be executed in counterparts,
each of which shall be an original and all of which together shall constitute
one and the same agreement among the parties.

            9. Section Titles. The section titles contained in this Amendment
are and shall be without substance, meaning or content of any kind whatsoever
and are not a part of the agreement between the parties hereto.

                                         * * * *

                                       5
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed and delivered by their proper and duly authorized officers as of
the day and year first above written.

                                       WATTS WATER TECHNOLOGIES, INC.

                                       By:  /s/ William C. McCartney
                                           --------------------------
                                       Name: William C. McCartney
                                       Title: Chief Financial Officer

                                       WATTS INDUSTRIES EUROPE B.V.

                                       By:  /s/ Johan van Kouterik
                                           --------------------------
                                       Name: Johan van Kouterik
                                       Title: Vice President & CFO

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

SUBSIDIARY GUARANTORS:

WATTS REGULATOR CO.                           WATTS PREMIER, INC.

By: /s/ William C. McCartney                  By: /s/ William C. McCartney
    ---------------------------                   ---------------------------
Name: William C. McCartney                    Name: William C. McCartney
Title: VP Finance                             Title: Treasurer

ANDERSON-BARROWS METALS CORPORATION           WATTS CAZZANIGA S.P.A.

By: /s/ William C. McCartney                  By: /s/ Johan van Kouterik
    ---------------------------                   ---------------------------
Name: William C. McCartney                    Name: Johan van Kouterik
Title: VP Finance                             Title: Vice President & CFO

WEBSTER VALVE, INC.                            WATTS LONDA S.P.A.

By: /s/ William C. McCartney                   By: /s/ Johan van Kouterik
    ---------------------------                    ---------------------------
Name: William C. McCartney                     Name: Johan van Kouterik
Title: VP Finance                              Title: Vice President & CFO

HUNTER INNOVATIONS, INC.                       WATTS INTERMES S.R.L.

By: /s/ William C. McCartney                   By: /s/ Johan van Kouterik
    ---------------------------                    ---------------------------
Name: William C. McCartney                     Name: Johan van Kouterik
Title: Chief Financial Officer                 Title: Vice President & CFO

WATTS DISTRIBUTION COMPANY, INC.               GIULIANI ANELLO S.R.L.

By: /s/ William C. McCartney                   By: /s/ Johan van Kouterik
    ---------------------------                    ---------------------------
Name: William C. McCartney                     Name: Johan van Kouterik
Title: Treasurer                               Title: Vice President & CFO

WATTS RADIANT, INC.

By: /s/ William C. McCartney
    ---------------------------
Name: William C. McCartney
Title: Treasurer

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         BANK OF AMERICA, N.A., as

                                         Administrative Agent

                                         By:  /s/ David A Johanson
                                             ----------------------
                                         Name:  David A. Johanson
                                         Title:  Vice President

                                         BANK OF AMERICA, N.A., as a Lender

                                         By:  /s/ Jennifer L. Gerdes
                                             ----------------------
                                         Name:  Jennifer L. Gerdes
                                         Title: Senior Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         JPMORGAN CHASE BANK, N.A.,
                                         as a Lender

                                         By:  /s/ Peter M. Killea
                                             ----------------------
                                         Name:  Peter M. Killea
                                         Title:  Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement

<PAGE>

                                         WACHOVIA BANK, NATIONAL ASSOCIATION,
                                         as a Lender

                                         By:  /s/ Sarah T. Warren
                                             ----------------------
                                         Name:  Sarah T. Warren
                                         Title:  Director

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         KEYBANK NATIONAL ASSOCIATION,
                                         as a Lender

                                         By:  /s/ Thomas J. Purcell
                                             ----------------------
                                         Name:  Thomas J. Purcell
                                         Title:  Senior Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         SUNTRUST BANK, as a Lender

                                         By:  /s/ Robert W. Maddox
                                             ----------------------
                                         Name:  Robert W. Maddox
                                         Title:  Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         HSBC BANK USA, N.A., as a Lender

                                         By:  /s/ Dan Lobdell
                                             ----------------------
                                         Name:  Dan Lobdell
                                         Title:  Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         LASALLE BANK NATIONAL ASSOCIATION,
                                         as a Lender

                                         By:  /s/ Gary A. Pirri
                                             ----------------------
                                         Name:  Gary A. Pirri
                                         Title:  Senior Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         CITIZENS BANK OF MASSACHUSETTS,
                                         as a Lender

                                         By:  /s/ Daniel Bernard
                                             ----------------------
                                         Name:  Daniel Bernard
                                         Title:  Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         CALYON NEW YORK BRANCH,
                                         as a Lender

                                         By:  /s/ Scott R. Chappelka
                                             ----------------------
                                         Name:  Scott R. Chappelka
                                         Title:  Director

                                         By:  /s/ Phillip Schubert
                                             ----------------------
                                         Name:  Phillip Schubert
                                         Title:  Director

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty Agreement
<PAGE>

                                         BROWN BROTHERS HARRIMAN & CO., as a
                                         Lender

                                         By:  /s/ John D. Rogers
                                             ----------------------
                                         Name:  John D. Rogers
                                         Title:  Senior Vice President

                                Signature Page to
                     Amendment No. 1 to Credit Agreement and
                      Amendment No. 1 to Guaranty AgreementRESTATED CERTIFICATE OF INCORPORATION OF THE REGISTRANT

 Exhibit 4.1 
  

RESTATED 
 CERTIFICATE OF INCORPORATION

 OF 
 ICAGEN, INC. 
 Pursuant to Sections 242 and 245 
 of the
General Corporation Law of 
 the State of Delaware 
  
 Icagen, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of
Delaware, does hereby certify as follows: 
  
 1. The name of the
Corporation is Icagen, Inc. 
  
 2. The Corporation’s original
Certificate of Incorporation was filed with the Secretary of State of the State of Delaware on November 23, 1992 and was amended and restated by a First Amended and Restated Certificate of Incorporation filed on December 15, 2003 (collectively, the
“Certificate of Incorporation”). 
  
 3. At a
meeting of the Board of Directors of the Corporation, a resolution was duly adopted, pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware, setting forth a Restated Certificate of Incorporation of the Corporation
(the “Restated Certificate”), which restates, integrates and further amends the Certificate of Incorporation and declaring said Restated Certificate to be advisable. The stockholders of the Corporation duly approved said proposed
Restated Certificate at a duly called and noticed meeting of stockholders in accordance with Sections 242 and 245 of the General Corporation Law of the State of Delaware. The resolution setting forth the Restated Certificate is as follows:

  
 RESOLVED: That the Certificate of Incorporation of the
Corporation, as heretofore amended, be amended and restated to read in its entirety as follows: 
  
 FIRST: The name of the Corporation is Icagen, Inc. 
  
 SECOND: The address of the registered office of the Corporation in the State of Delaware is 2711 Centerville Road, Suite 400, Wilmington, New Castle
County, Delaware 19808 and the registered agent is Corporation Service Company. 
  
 THIRD: The purpose for which the Corporation is organized is to engage in any lawful act or activity for which corporations may be organized under the General Corporation Law of the State of Delaware. 
  
 FOURTH: The total number of shares of all classes of stock which the
Corporation shall have authority to issue is 100,000,000 shares, consisting of (i) 90,000,000 shares of Common Stock, $.001 par value per share (“Common Stock”), and (ii) 10,000,000 shares of Preferred Stock, $.001 par value per
share (“Preferred Stock”). 

 The following is a statement of the designations and the powers, privileges and rights, and the
qualifications, limitations or restrictions thereof in respect of each class of capital stock of the Corporation. 
  
 A. COMMON STOCK. 
  
 1. General. The voting, dividend and liquidation rights of the holders of the Common Stock are subject to and qualified by the rights of the
holders of the Preferred Stock of any series as may be designated by the Board of Directors upon any issuance of the Preferred Stock of any series. 
  
 2. Voting. The holders of the Common Stock shall have voting rights at all meetings of stockholders, each such holder being entitled to one vote
for each share thereof held by such holder; provided, however, that, except as otherwise required by law, holders of Common Stock shall not be entitled to vote on any amendment to this Certificate of Incorporation (which, as used
herein, shall mean the certificate of incorporation of the Corporation, as amended from time to time, including the terms of any certificates of designation of any series of Preferred Stock) that relates solely to the terms of one or more
outstanding series of Preferred Stock if the holders of such affected series are entitled, either separately or together as a class with the holders of one or more other such series, to vote thereon pursuant to this Certificate of Incorporation.
There shall be no cumulative voting. 
  
 The number of authorized
shares of Common Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders of a majority of the stock of the Corporation entitled to vote, irrespective of the provisions
of Section 242(b)(2) of the General Corporation Law of Delaware. 
  
 3. Dividends. Dividends may be declared and paid on the Common Stock from funds lawfully available therefor as and when determined by the Board of Directors and subject to any preferential dividend rights of any then outstanding
Preferred Stock. 
  
 4. Liquidation. Upon the dissolution
or liquidation of the Corporation, whether voluntary or involuntary, holders of Common Stock will be entitled to receive all assets of the Corporation available for distribution to its stockholders, subject to any preferential rights of any then
outstanding Preferred Stock. 
  
 B. PREFERRED
STOCK. 
  
 Preferred Stock may be issued from time to time in
one or more series, each of such series to have such terms as stated or expressed herein and in the resolution or resolutions providing for the issue of such series adopted by the Board of Directors of the Corporation as hereinafter provided. Any
shares of Preferred Stock which may be redeemed, purchased or acquired by the Corporation may be reissued except as otherwise provided herein or by law. Different series of Preferred Stock shall not be construed to constitute different classes of
shares for the purposes of voting by classes unless expressly provided. 
  

 2 

 Authority is hereby expressly granted to the Board of Directors from time to time to issue the Preferred
Stock in one or more series, and in connection with the creation of any such series, by resolution or resolutions providing for the issue of the shares thereof, to determine and fix the number of shares of such series and such voting powers, full or
limited, or no voting powers, and such designations, preferences and relative participating, optional or other special rights, and qualifications, limitations or restrictions thereof, including without limitation thereof, dividend rights, conversion
rights, redemption privileges and liquidation preferences, as shall be stated and expressed in such resolutions, all to the full extent now or hereafter permitted by the General Corporation Law of Delaware. Without limiting the generality of the
foregoing, the resolutions providing for issuance of any series of Preferred Stock may provide that such series shall be superior or rank equally or be junior to the Preferred Stock of any other series to the extent permitted by law. Except as
otherwise provided in this Certificate of Incorporation, no vote of the holders of the Preferred Stock or Common Stock shall be a prerequisite to the designation or issuance of any shares of any series of the Preferred Stock authorized by and
complying with the conditions of this Certificate of Incorporation, the right to have such vote being expressly waived by all present and future holders of the capital stock of the Corporation. 
  
 The number of authorized shares of Preferred Stock may be increased or
decreased (but not below the number of shares then outstanding) by the affirmative vote of the holders of a majority of the stock of the Corporation entitled to vote, irrespective of the provisions of Section 242(b)(2) of the General Corporation Law
of Delaware. 
  
 FIFTH: Except as otherwise provided herein, the
Corporation reserves the right to amend, alter, change or repeal any provision contained in this Certificate of Incorporation, in the manner now or hereafter prescribed by statute and this Certificate of Incorporation, and all rights conferred upon
stockholders herein are granted subject to this reservation. 
  
 SIXTH: In furtherance and not in limitation of the powers conferred upon it by the laws of the State of Delaware, and subject to the terms of any series of Preferred Stock, the Board of Directors shall have the power to adopt, amend, alter
or repeal the Corporation’s Bylaws. The affirmative vote of a majority of the directors present at any regular or special meeting of the Board of Directors at which a quorum is present shall be required to adopt, amend, alter or repeal the
Corporation’s Bylaws. The Corporation’s Bylaws also may be adopted, amended, altered or repealed by the affirmative vote of the holders of at least seventy-five percent (75%) of the votes which all the stockholders would be entitled to
cast in any annual election of directors or class of directors, in addition to any other vote required by this Certificate of Incorporation. Notwithstanding any other provisions of law, this Certificate of Incorporation or the Bylaws of the
Corporation, and notwithstanding the fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at least seventy-five percent (75%) of the votes which all the stockholders would be entitled to cast in any annual
election of directors or class of directors shall be required to amend or repeal, or to adopt any provision inconsistent with, this Article SIXTH. 
  
 SEVENTH: Except to the extent that the General Corporation Law of Delaware prohibits the elimination or limitation of liability of directors for breaches
of fiduciary duty, no director of 
  

 3 

 the Corporation shall be personally liable to the Corporation or its stockholders for monetary damages for any breach of
fiduciary duty as a director, notwithstanding any provision of law imposing such liability. No amendment to or repeal of this provision shall apply to or have any effect on the liability or alleged liability of any director of the Corporation for or
with respect to any acts or omissions of such director occurring prior to such amendment or repeal. 
  
 EIGHTH: The Corporation shall provide indemnification as follows: 
  
 1. Actions, Suits and Proceedings Other than by or in the Right of the Corporation. The Corporation shall indemnify
each person who was or is a party or threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the
Corporation) by reason of the fact that he or she is or was, or has agreed to become, a director or officer of the Corporation, or is or was serving, or has agreed to serve, at the request of the Corporation, as a director, officer, partner,
employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan) (all such persons being referred to hereafter as an “Indemnitee”), or
by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by or on behalf of Indemnitee in
connection with such action, suit or proceeding and any appeal therefrom, if Indemnitee acted in good faith and in a manner which Indemnitee reasonably believed to be in, or not opposed to, the best interests of the Corporation, and, with respect to
any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction or upon a plea of nolo contendere or its
equivalent, shall not, of itself, create a presumption that Indemnitee did not act in good faith and in a manner which Indemnitee reasonably believed to be in, or not opposed to, the best interests of the Corporation, and, with respect to any
criminal action or proceeding, had reasonable cause to believe that his or her conduct was unlawful. 
  
 2. Actions or Suits by or in the Right of the Corporation. The Corporation shall indemnify any Indemnitee who was or is a party to or threatened to
be made a party to any threatened, pending or completed action or suit by or in the right of the Corporation to procure a judgment in its favor by reason of the fact that Indemnitee is or was, or has agreed to become, a director or officer of the
Corporation, or is or was serving, or has agreed to serve, at the request of the Corporation, as a director, officer, partner, employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other
enterprise (including any employee benefit plan), or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees) and, to the extent permitted by law, amounts paid in
settlement actually and reasonably incurred by or on behalf of Indemnitee in connection with such action, suit or proceeding and any appeal therefrom, if Indemnitee acted in good faith and in a manner which Indemnitee reasonably believed to be in,
or not opposed to, the best interests of the Corporation, except that no indemnification shall be made under this Section 2 in respect of any claim, issue or matter as to which Indemnitee shall have been adjudged to be liable to the Corporation,
unless, and only to the extent, that the Court of Chancery of Delaware shall determine upon application that, despite the adjudication of such liability but in view of all the circumstances of the case, Indemnitee is fairly and reasonably entitled
to indemnity for such expenses (including attorneys’ fees) which the Court of Chancery of Delaware shall deem proper. 
  

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 3. Indemnification for Expenses of Successful Party. Notwithstanding any other provisions of this
Article, to the extent that an Indemnitee has been successful, on the merits or otherwise, in defense of any action, suit or proceeding referred to in Sections 1 and 2 of this Article EIGHTH, or in defense of any claim, issue or matter therein, or
on appeal from any such action, suit or proceeding, Indemnitee shall be indemnified against all expenses (including attorneys’ fees) actually and reasonably incurred by or on behalf of Indemnitee in connection therewith. Without limiting the
foregoing, if any action, suit or proceeding is disposed of, on the merits or otherwise (including a disposition without prejudice), without (i) the disposition being adverse to Indemnitee, (ii) an adjudication that Indemnitee was liable to the
Corporation, (iii) a plea of guilty or nolo contendere by Indemnitee, (iv) an adjudication that Indemnitee did not act in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the
Corporation, and (v) with respect to any criminal proceeding, an adjudication that Indemnitee had reasonable cause to believe his conduct was unlawful, Indemnitee shall be considered for the purposes hereof to have been wholly successful with
respect thereto. 
  
 4. Notification and Defense of Claim.
As a condition precedent to an Indemnitee’s right to be indemnified, such Indemnitee must notify the Corporation in writing as soon as practicable of any action, suit, proceeding or investigation involving such Indemnitee for which indemnity
will or could be sought. With respect to any action, suit, proceeding or investigation of which the Corporation is so notified, the Corporation will be entitled to participate therein at its own expense and/or to assume the defense thereof at its
own expense, with legal counsel reasonably acceptable to Indemnitee. After notice from the Corporation to Indemnitee of its election so to assume such defense, the Corporation shall not be liable to Indemnitee for any legal or other expenses
subsequently incurred by Indemnitee in connection with such action, suit, proceeding or investigation, other than as provided below in this Section 4. Indemnitee shall have the right to employ his or her own counsel in connection with such action,
suit, proceeding or investigation, but the fees and expenses of such counsel incurred after notice from the Corporation of its assumption of the defense thereof shall be at the expense of Indemnitee unless (i) the employment of counsel by Indemnitee
has been authorized by the Corporation, (ii) counsel to Indemnitee shall have reasonably concluded that there may be a conflict of interest or position on any significant issue between the Corporation and Indemnitee in the conduct of the defense of
such action, suit, proceeding or investigation or (iii) the Corporation shall not in fact have employed counsel to assume the defense of such action, suit, proceeding or investigation, in each of which cases the fees and expenses of counsel for
Indemnitee shall be at the expense of the Corporation, except as otherwise expressly provided by this Article. The Corporation shall not be entitled, without the consent of Indemnitee, to assume the defense of any claim brought by or in the right of
the Corporation or as to which counsel for Indemnitee shall have reasonably made the conclusion provided for in clause (ii) above. The Corporation shall not be required to indemnify Indemnitee under this Article EIGHTH for any amounts paid in
settlement of any action, suit, proceeding or investigation effected without its written consent. The Corporation shall not settle any action, suit, proceeding or investigation in any manner which would impose any penalty or limitation on Indemnitee
without Indemnitee’s written consent. Neither the Corporation nor Indemnitee will unreasonably withhold or delay its consent to any proposed settlement. 
  

 5 

 5. Advance of Expenses. Subject to the provisions of Section 6 of this Article EIGHTH, in the
event that the Corporation does not assume the defense pursuant to Section 4 of this Article EIGHTH of any action, suit, proceeding or investigation of which the Corporation receives notice under this Article, any expenses (including attorneys’
fees) incurred by or on behalf of Indemnitee in defending an action, suit, proceeding or investigation or any appeal therefrom shall be paid by the Corporation in advance of the final disposition of such matter; provided, however, that the
payment of such expenses incurred by or on behalf of Indemnitee in advance of the final disposition of such matter shall be made only upon receipt of an undertaking by or on behalf of Indemnitee to repay all amounts so advanced in the event that it
shall ultimately be determined that Indemnitee is not entitled to be indemnified by the Corporation as authorized in this Article; and further provided that no such advancement of expenses shall be made under this Article EIGHTH if it is determined
(in the manner described in Section 6) that (i) Indemnitee did not act in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests of the Corporation, or (ii) with respect to any criminal action or
proceeding, Indemnitee had reasonable cause to believe his conduct was unlawful. Such undertaking shall be accepted without reference to the financial ability of Indemnitee to make such repayment. 
  
 6. Procedure for Indemnification. In order to obtain indemnification
or advancement of expenses pursuant to Section 1, 2, 3 or 5 of this Article EIGHTH, an Indemnitee shall submit to the Corporation a written request. Any such advancement of expenses shall be made promptly, and in any event within 30 days after
receipt by the Corporation of the written request of Indemnitee, unless the Corporation determines within such 30-day period that Indemnitee did not meet the applicable standard of conduct set forth in Section 1, 2 or 5 of this Article EIGHTH, as
the case may be. Any such indemnification, unless ordered by a court, shall be made with respect to requests under Section 1 or 2 only as authorized in the specific case upon a determination by the Corporation that the indemnification of Indemnitee
is proper because Indemnitee has met the applicable standard of conduct set forth in Section 1 or 2, as the case may be. Such determination shall be made in each instance (a) by a majority vote of the directors of the Corporation consisting of
persons who are not at that time parties to the action, suit or proceeding in question (“disinterested directors”), whether or not a quorum, (b) by a committee of disinterested directors designated by majority vote of disinterested
directors, whether or not a quorum, (c) if there are no disinterested directors, or if the disinterested directors so direct, by independent legal counsel (who may, to the extent permitted by law, be regular legal counsel to the Corporation) in a
written opinion, or (d) by the stockholders of the Corporation. 
  
 7. Remedies. The right to indemnification or advancement of expenses as granted by this Article shall be enforceable by Indemnitee in any court of competent jurisdiction. Neither the failure of the Corporation to have made a
determination prior to the commencement of such action that indemnification is proper in the circumstances because Indemnitee has met the applicable standard of conduct, nor an actual determination by the Corporation pursuant to Section 6 of this
Article EIGHTH that Indemnitee has not met such applicable standard of conduct, shall be a defense to the action or create a presumption that Indemnitee has not met the 
  

 6 

 applicable standard of conduct. Indemnitee’s expenses (including attorneys’ fees) reasonably incurred in
connection with successfully establishing Indemnitee’s right to indemnification, in whole or in part, in any such proceeding shall also be indemnified by the Corporation. 
  
 8. Limitations. Notwithstanding anything to the contrary in this Article, except as set forth in Section 7 of the
Article EIGHTH, the Corporation shall not indemnify an Indemnitee pursuant to this Article EIGHTH in connection with a proceeding (or part thereof) initiated by such Indemnitee unless the initiation thereof was approved by the Board of Directors of
the Corporation. Notwithstanding anything to the contrary in this Article, the Corporation shall not indemnify an Indemnitee to the extent such Indemnitee is reimbursed from the proceeds of insurance, and in the event the Corporation makes any
indemnification payments to an Indemnitee and such Indemnitee is subsequently reimbursed from the proceeds of insurance, such Indemnitee shall promptly refund indemnification payments to the Corporation to the extent of such insurance reimbursement.

  
 9. Subsequent Amendment. No amendment, termination or
repeal of this Article or of the relevant provisions of the General Corporation Law of Delaware or any other applicable laws shall affect or diminish in any way the rights of any Indemnitee to indemnification under the provisions hereof with respect
to any action, suit, proceeding or investigation arising out of or relating to any actions, transactions or facts occurring prior to the final adoption of such amendment, termination or repeal. 
  
 10. Other Rights. The indemnification and advancement of expenses
provided by this Article shall not be deemed exclusive of any other rights to which an Indemnitee seeking indemnification or advancement of expenses may be entitled under any law (common or statutory), agreement or vote of stockholders or
disinterested directors or otherwise, both as to action in Indemnitee’s official capacity and as to action in any other capacity while holding office for the Corporation, and shall continue as to an Indemnitee who has ceased to be a director or
officer, and shall inure to the benefit of the estate, heirs, executors and administrators of Indemnitee. Nothing contained in this Article shall be deemed to prohibit, and the Corporation is specifically authorized to enter into, agreements with
officers and directors providing indemnification rights and procedures different from those set forth in this Article. In addition, the Corporation may, to the extent authorized from time to time by its Board of Directors, grant indemnification
rights to other employees or agents of the Corporation or other persons serving the Corporation and such rights may be equivalent to, or greater or less than, those set forth in this Article. 
  
 11. Partial Indemnification. If an Indemnitee is entitled under any
provision of this Article to indemnification by the Corporation for some or a portion of the expenses (including attorneys’ fees), judgments, fines or amounts paid in settlement actually and reasonably incurred by or on behalf of Indemnitee in
connection with any action, suit, proceeding or investigation and any appeal therefrom but not, however, for the total amount thereof, the Corporation shall nevertheless indemnify Indemnitee for the portion of such expenses (including
attorneys’ fees), judgments, fines or amounts paid in settlement to which Indemnitee is entitled. 
  
 12. Insurance. The Corporation may purchase and maintain insurance, at its expense, to protect itself and any director, officer, employee or agent
of the Corporation or another 
  

 7 

 corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan) against any
expense, liability or loss incurred by him in any such capacity, or arising out of his status as such, whether or not the Corporation would have the power to indemnify such person against such expense, liability or loss under the General Corporation
Law of Delaware. 
  
 13. Savings Clause. If this Article or
any portion hereof shall be invalidated on any ground by any court of competent jurisdiction, then the Corporation shall nevertheless indemnify each Indemnitee as to any expenses (including attorneys’ fees), judgments, fines and amounts paid in
settlement in connection with any action, suit, proceeding or investigation, whether civil, criminal or administrative, including an action by or in the right of the Corporation, to the fullest extent permitted by any applicable portion of this
Article that shall not have been invalidated and to the fullest extent permitted by applicable law. 
  
 14. Definitions. Terms used herein and defined in Section 145(h) and Section 145(i) of the General Corporation Law of Delaware shall have the
respective meanings assigned to such terms in such Section 145(h) and Section 145(i). 
  
 NINTH: This Article is inserted for the management of the business and for the conduct of the affairs of the Corporation. 
  
 1. General Powers. The business and affairs of the Corporation shall be managed by or under the direction of the Board of Directors. 
  
 2. Number of Directors; Election of Directors. Subject to the rights
of holders of any series of Preferred Stock to elect directors, the number of directors of the Corporation shall be established by the Board of Directors. Election of directors need not be by written ballot, except as and to the extent provided in
the Bylaws of the Corporation. 
  
 3. Classes of Directors.
Subject to the rights of holders of any series of Preferred Stock to elect directors, the Board of Directors shall be and is divided into three classes: Class I, Class II and Class III. 
  
 4. Terms of Office. Subject to the rights of holders of any series of Preferred Stock to elect directors, each
director shall serve for a term ending on the date of the third annual meeting following the annual meeting at which such director was elected; provided, that each director initially appointed to Class I shall serve for a term expiring at the
Corporation’s annual meeting of stockholders held in 2005; each director initially appointed to Class II shall serve for a term expiring at the Corporation’s annual meeting of stockholders held in 2006; and each director initially
appointed to Class III shall serve for a term expiring at the Corporation’s annual meeting of stockholders held in 2007; provided further, that the term of each director shall continue until the election and qualification of his successor and
be subject to his earlier death, resignation or removal. 
  
 5.
Quorum. The greater of (a) a majority of the directors at any time in office and (b) one-third of the number of directors fixed pursuant to Section 2 of this Article NINTH shall constitute a quorum. If at any meeting of the Board of Directors
there shall be less than such a quorum, a majority of the directors present may adjourn the meeting from time to time without further notice other than announcement at the meeting, until a quorum shall be present. 
  

 8 

 6. Action at Meeting. Every act or decision done or made by a majority of the directors present at
a meeting duly held at which a quorum is present shall be regarded as the act of the Board of Directors unless a greater number is required by law or by this Certificate of Incorporation. 
  
 7. Removal. Subject to the rights of holders of any series of Preferred Stock, directors of the Corporation may be
removed only for cause and only by the affirmative vote of the holders of at least seventy-five percent (75%) of the votes which all the stockholders would be entitled to cast in any annual election of directors or class of directors. 
  
 8. Vacancies. Subject to the rights of holders of any series of
Preferred Stock, any vacancy or newly created directorships in the Board of Directors, however occurring, shall be filled only by vote of a majority of the directors then in office, although less than a quorum, or by a sole remaining director and
shall not be filled by the stockholders. A director elected to fill a vacancy shall hold office until the next election of the class for which such director shall have been chosen, subject to the election and qualification of a successor and to such
director’s earlier death, resignation or removal. 
  
 9.
Stockholder Nominations and Introduction of Business, Etc. Advance notice of stockholder nominations for election of directors and other business to be brought by stockholders before a meeting of stockholders shall be given in the manner
provided by the Bylaws of the Corporation. 
  
 10. Amendments
to Article. Notwithstanding any other provisions of law, this Certificate of Incorporation or the Bylaws of the Corporation, and notwithstanding the fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at
least seventy-five percent (75%) of the votes which all the stockholders would be entitled to cast in any annual election of directors or class of directors shall be required to amend or repeal, or to adopt any provision inconsistent with, this
Article NINTH. 
  
 TENTH: Stockholders of the Corporation may not
take any action by written consent in lieu of a meeting. Notwithstanding any other provisions of law, this Certificate of Incorporation or the Bylaws of the Corporation, and notwithstanding the fact that a lesser percentage may be specified by law,
the affirmative vote of the holders of at least seventy-five percent (75%) of the votes which all the stockholders would be entitled to cast in any annual election of directors or class of directors shall be required to amend or repeal, or to adopt
any provision inconsistent with, this Article TENTH. 
  
 ELEVENTH:
Special meetings of stockholders for any purpose or purposes may be called at any time by the Board of Directors, the Chairman of the Board or the President or Chief Executive Officer, but such special meetings may not be called by any other person
or persons. Business transacted at any special meeting of stockholders shall be limited to matters relating to the purpose or purposes stated in the notice of meeting. Notwithstanding any other provision of law, this Certificate of Incorporation or
the Bylaws of the Corporation, and notwithstanding the 
  

 9 

 fact that a lesser percentage may be specified by law, the affirmative vote of the holders of at least seventy-five
percent (75%) of the votes which all the stockholders would be entitled to cast in any annual election of directors or class of directors shall be required to amend or repeal, or to adopt any provision inconsistent with, this Article ELEVENTH.

  
 IN WITNESS WHEREOF, this Restated Certificate of
Incorporation, which restates, integrates and amends the certificate of incorporation of the Corporation, and which has been duly adopted in accordance with Sections 228, 242 and 245 of the Delaware General Corporation Law, has been executed by its
duly authorized officer this 7th day of February, 2005. 
  

			
	 Icagen, Inc.

		
	 By:
	 	 /s/    P. Kay Wagoner

	 	 	 Name: P. Kay Wagoner

	 	 	 Title: President and Chief Executive Officer

  

 10

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