Document:

Exhibit

March 2, 2017
Leonard Bell, M.D.
By Hand and by Email
Dear Dr. Bell:
Effective as of the date hereof, this letter (the "Amendment") amends the letter agreement between you and Alexion Pharmaceuticals, Inc. (the "Company"), dated April 1, 2015, setting forth the treatment of certain outstanding equity awards granted to you by the Company (the "Letter Agreement").  All capitalized terms used in this Amendment shall have the meanings ascribed to them in the Letter Agreement unless otherwise expressly provided herein.
In consideration of your service on the Company’s Board of Directors and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, you and the Company agree to amend the Letter Agreement as follows:  
1.    Amendment to Section 2(a) of the Letter Agreement.  Section 2(a) of the Letter Agreement is hereby amended as follows:  
A.    The first sentence is hereby amended by substituting the phrase "March 2, 2017" for the phrase "March 31, 2015".  
B.    The second sentence is hereby amended by substituting the phrase "March 2, 2017" for the phrase "after the date hereof" immediately prior to the period.
2.    Amendment to Section 2(c) of the Letter Agreement.  Section 2(c) of the Letter Agreement is hereby amended in its entirety to read as follows:
"Notwithstanding the foregoing or the provisions of the Equity Plan or any applicable Equity Award agreement to the contrary, if (i) your service on the Board is terminated due to your death, or your service on the Board involuntarily terminates without Cause (as defined below) (e.g., the Board does not nominate you for reelection under circumstances where you are otherwise willing to continue to serve on the Board), (ii) your term of service on Board terminates  because you do not stand for reelection as a Director at the Company’s 2017 annual meeting of stockholders, or (iii) a Change in Control occurs, any then outstanding and unvested Restricted Units and Performance Units that are then "Earned Units" (as determined in accordance with the terms of the applicable Performance Unit award and Section 2(d) of this Agreement) will vest in full and any then outstanding and unvested Stock Options will vest in full and become exercisable and each Stock Option will remain exercisable until the expiration of its original term.  Upon any other termination of your service on the Board, any then outstanding and unvested Equity Awards will terminate."

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3.    Effect of Amendment; Miscellaneous.  Except as expressly amended herein, the Letter Agreement will continue in full force and effect in accordance with its terms.  The Letter Agreement, as amended by the Amendment, embodies the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior communications, agreements and understandings, whether written or oral, with respect to the same.  This Amendment may be executed in one or more counterparts, each of which shall be deemed to be an original, but all of which taken together shall constitute one and the same instrument.  This Amendment is a Delaware contract and will be will be construed and enforced under and be governed in all respects by the laws of the State of Delaware, without regard to any conflict of laws principles that would result in the application of the laws of any other jurisdiction.
[Remainder of page intentionally left blank.]

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This Amendment has been executed by the Company, by its duly authorized representative, and by Dr. Bell as of the date first written above. 

ALEXION PHARMACEUTICALS, INC.

By:     /s/ Michael V. Greco            

Title:     SVP of Law and Corporate Secretary    

LEONARD BELL, M.D.

/s/ Leonard Bell        
Signature

3Exhibit 4.1

 

	RIGHTS CERTIFICATE #:	NUMBER OF RIGHTS

 

THE TERMS AND CONDITIONS OF THE RIGHTS OFFERING
ARE SET FORTH IN THE COMPANY'S PROSPECTUS SUPPLEMENT

DATED MARCH 2, 2017 (THE "PROSPECTUS
SUPPLEMENT") AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF

THE PROSPECTUS SUPPLEMENT AND ACCOMPANYING
PROSPECTUS ARE AVAILABLE UPON REQUEST FROM D.F. KING & CO., INC., THE INFORMATION AGENT.

 

Trinity Place Holdings Inc.

Incorporated under
the laws of the State of Delaware

 

NON
- TRANSFERABLE SUBSCRIPTION RIGHTS CERTIFICATE

 

Evidencing Non - Transferable Subscription Rights
to Purchase Shares of Common Stock of Trinity Place Holdings Inc.

 

Subscription Price:     $7.50
per Share

 

THE SUBSCRIPTION
RIGHTS WILL EXPIRE IF NOT EXERCISED ON OR BEFORE 5:00 P.M., NEW YORK CITY TIME,

ON MARCH 31, 2017, UNLESS EXTENDED BY THE COMPANY

 

	REGISTERED

        OWNER:

         
	 	 	 	 

 

 

 

 

	 	
        THIS CERTIFIES THAT the registered owner whose name is inscribed
        hereon is the owner of the number of non-transferable subscription rights (“Rights”) set forth above. Each whole Right
        entitles the holder thereof to subscribe for and purchase one share of Common Stock, with a par value of $0.01 per share, of Trinity
        Place Holdings Inc., a Delaware corporation, at a subscription price of $7.50 per share (the “Basic Subscription Privilege”),
        pursuant to a rights offering (the “Rights Offering”), on the terms and subject to the conditions set forth in the
        Prospectus Supplement and the “Instructions as to Use of Trinity Place Holdings Inc. Subscription Rights Certificates”
        accompanying this Subscription Rights Certificate.

         

        This Subscription Rights Certificate is not valid unless countersigned
        by the subscription agent and registered by the registrar. Witness the seal of Trinity Place Holdings Inc. and the signatures of
        its duly authorized officers.

         

        Dated: March 2, 2017

         
	 	If any shares of Common Stock available for purchase in the Rights Offering are not purchased by  other holders of Rights pursuant to the exercise of their Basic Subscription Privilege (the “Unsubscribed Shares”), any Rights holder that exercises its Basic Subscription Privilege in full may subscribe for a number of Unsubscribed Shares pursuant to the terms and conditions of the Rights Offering, subject to proration, as  described in the Prospectus (the “Over-Subscription Privilege”).   The Rights represented by this  Subscription Rights Certificate may be exercised by completing the appropriate forms on the reverse  side hereof and by returning the full payment of the subscription price for each share of Common Stock in accordance with the “Instructions as to Use of Trinity Place Holdings Inc. Subscription Rights Certificates” that accompany this Subscription Rights Certificate 	 
	 	/s/ Matthew Messinger	 	/s/ Richard Pyontek
	 	President and Chief Executive Officer	 	Secretary

 

 

     

     

    

 

 

DELIVERY OPTIONS FOR SUBSCRIPTION RIGHTS
CERTIFICATE

Delivery other than in the manner or to the
address listed below will not constitute valid delivery.

 

If delivering by mail, hand or overnight
courier:

 

American Stock Transfer & Trust Company,
LLC

Operations Center

Attn: Reorganization Department

6201 15th Avenue

Brooklyn, New York 11219

 

PLEASE PRINT ALL INFORMATION CLEARLY AND
LEGIBLY.

 

FORM 1-EXERCISE OF SUBSCRIPTION RIGHTS

 

To subscribe for shares pursuant
to your Basic Subscription Privilege, please complete lines (a) and (c) below, check the appropriate box under Form 4 and sign
under Form 5 and, if applicable, complete Form 6. To subscribe for shares pursuant to your Over-Subscription Privilege, please
also complete line (b) and sign under Form 5. To the extent you subscribe for more Shares than you are entitled under either the
Basic Subscription Privilege or the Over-Subscription Privilege, you will be deemed to have elected to purchase the maximum number
of shares for which you are entitled to subscribe under the Basic Subscription Privilege or Over-Subscription Privilege, as applicable.

 

(a) EXERCISE OF BASIC SUBSCRIPTION PRIVILEGE:

 

I apply for ______________ shares    x  $ 7.50 =        $_______________

(no. of shares)              (subscription price)  (amount enclosed)

 

(b) EXERCISE OF OVER-SUBSCRIPTION PRIVILEGE

 

If you have exercised your Basic Subscription Privilege
in full and wish to subscribe for additional shares pursuant to your Over-Subscription Privilege:

 

I apply for ______________ shares x $ 7.50 =        $_______________

(no. of shares)            (subscription price) (amount enclosed)

 

(c) Total Amount
of Payment Enclosed = $__________________

 

METHOD OF PAYMENT (CHECK ONE)

 

		 ̈	Wire transfer of immediately available
funds directly to the account maintained by American Stock Transfer & Trust Company, LLC, as Subscription Agent, for purposes
of accepting subscriptions in this Rights Offering at JPMorgan Chase Bank, 55 Water Street, New York, New York 10005, ABA #021000021,
Account # 530-354616 American Stock Transfer FBO Trinity Place Holdings Inc., with reference to the rights holder's name.

		 ̈	Check or bank draft payable to “American
Stock Transfer & Trust Company, LLC (acting as subscription agent for Trinity Place Holdings Inc.)”.

 

FORM 2-DELIVERY TO DIFFERENT ADDRESS

 

If you wish for the Common Stock underlying
your subscription rights or a certificate representing unexercised subscription rights to be delivered to an address different
from that shown on the face of this Subscription Rights Certificate, please enter the alternate address below, sign under Form
5 and have your signature guaranteed under Form 6. 

	 	 
	 	 
	 	 

  

FORM 3-LIMIT OWNERSHIP TO SPECIFIED
PERCENTAGE 

 

If you wish to own less than a specified
percentage of the outstanding Common Stock of the Company upon completion of this rights offering, please specify such percentage
here: _________%

 

In order for this election to be
effective, you must also contact the information agent, D.F. King & Co., Inc., at (212) 493-3918.

 

Please inform us of the number of
shares of common stock that you currently own without counting any shares to be issued upon exercise of these rights.

 

__________________________________
shares of common stock currently owned.

 

FORM 4 – STOCK OWNERSHIP FOLLOWING EXERCISE OF RIGHTS

 

(CHECK ONE)

 

		 ̈	You currently hold 1,393,000 or more shares
of the Company’s common stock.

 

		 ̈	You currently hold less than 1,393,000
shares of the Company’s common stock, but you are subscribing for a number of shares through the exercise of your Basic Subscription
Privilege and, if applicable, Over-Subscription Privilege, that would, if accepted by the Company, result in you holding 1,393,000
or more shares of the Company’s common stock following the closing of the rights offering.

 

		 ̈	Neither of the above is applicable.

 

IMPORTANT: If you checked the
first or second box, you must notify the Company by completing and returning directly to the Company the “Notification
of 4.75% Holder Form” included with the subscription documents, as you may be required to submit additional information to
the Company in connection with the exercise of your Basic Subscription privilege, and, if applicable, your Over-Subscription Privilege.
See the “Instructions as to Use of Trinity Place Holdings Inc. Subscription Rights Certificates” for more information.

 

FORM 5-SIGNATURE

 

TO SUBSCRIBE: I acknowledge that I
have received the Prospectus Supplement and accompanying Prospectus for this Rights Offering and I hereby irrevocably subscribe
for the number of shares indicated above on the terms and conditions specified in the Prospectus Supplement. I agree to cooperate
with the Company and provide to the Company any and all information requested by the Company in connection with the exercise of
the rights.

 

	Signature(s):	 	 
	 	 	 
	 	 	 
	 	(Print Name of Signatory and Capacity in which Signed if an Entity)	 

  

IMPORTANT: The signature(s) must correspond
with the name(s) as printed on the reverse of this Subscription Rights Certificate in every particular, without alteration or enlargement,
or any other change whatsoever.

 

FORM 6-SIGNATURE GUARANTEE

 

This form must be completed if you have completed any portion
of Form 2.

 

	Signature Guaranteed:	 	 
	 	(Name of Bank or Firm)	 

 

	By:	 	 
	 	(Signature of Officer)	 

 

IMPORTANT: The signature(s) should
be guaranteed by an eligible guarantor institution (bank, stock broker, savings & loan association or credit union) with membership
in an approved signature guarantee medallion program pursuant to Securities and Exchange Commission Rule 17Ad-15.

 

FOR INSTRUCTIONS ON THE USE OF
TRINITY PLACE HOLDINGS INC. SUBSCRIPTION RIGHTS CERTIFICATES, CONSULT DF KING & CO., INC., THE INFORMATION AGENT, AT (866)
751-6308.

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