Document:

EX-10.1

AMENDMENT NO. 1 TO LOAN AND SECURITY AGREEMENT

This Amendment No. 1 (“Amendment”) amends that certain Loan and Security Agreement dated as of
September 1, 2009 by and between Terry M. Giles and Pacific Biomarkers, Inc. (the “Agreement”).
Capitalized terms used in this Amendment without being defined shall have their respective meanings
set forth in the Agreement.

The parties desire to amend the repayment terms of the Loan to reamortize the Loan and extend
the term for a portion of the Loan. This Amendment shall be effective as of October 1, 2010 (the
“Amendment Effective Date”).

The parties agree as follows:

1. As of the Amendment Effective Date, the outstanding principal Loan balance was
$3,667,769.87, consisting of $1,178,490.13 (the “Extended Amount”) and $2,489,279.74 (the
“Remaining Amount”).

2. Section 1.2 of the Agreement (Maturity of Loan) is amended to read in its entirety as
follows:

“The term of the Loan is as follows: (a) the Remaining Amount of the Loan shall be for
a term of 48 months from the Closing Date, unless earlier repaid (the “Term”), and Borrower
hereby promises to pay to Lender all remaining unpaid principal, accrued and unpaid
interest, and any other amounts due with respect to the Remaining Amount of the Loan on or
before September 1, 2013 (the “Original Maturity Date”); and (b) the Extended Amount of the
Loan shall be for a term of 55 months from the Amendment Effective Date, unless earlier
repaid (the “Extended Term”), and Borrower hereby promises to pay to Lender all remaining
unpaid principal, accrued and unpaid interest, and any other amounts due with respect to the
Extended Amount of the Loan on or before April 30, 2015 (the “Extended Maturity Date”).

3. Section 1.4(a) of the Agreement (Loan Payment Schedule) is amended to read in its entirety
as follows:

“From the Amendment Effective Date, Borrower shall make payments to Lender on the Loan on the
following schedule:

	 	 	 	“(i) With respect to the Remaining Amount: (1) Borrower shall make
regular monthly payments of principal and interest ($84,644.68 each) beginning
on October 31, 2010 and on the last business day of each succeeding calendar
month according to amortization schedule on Schedule A-1, and (2) on
the Original Maturity Date, Borrower shall make a final payment of all
outstanding principal, accrued interest, and any and all unpaid fees and other
charges owed.

	 	 	 	“(ii) With respect to the Extended Amount: (1) Borrower shall make
regular monthly payments of principal and interest ($20,000.00 each) beginning
on October 31, 2010 and on the last business day of each succeeding calendar
month according to amortization schedule on Schedule A-2, and (2) on
the Extended Maturity Date, Borrower shall make a balloon payment of
$600,000.00 plus payment of any remaining outstanding principal, accrued
interest, and any and all unpaid fees and other charges owed.”

4. Section 1.5 of the Agreement (No Prepayment Penalties) is amended to read in its entirety
as follows:

“The Loan may be prepaid, in full or in part, at any time prior to the Extended
Maturity Date without premium or penalty and any such payment will be applied first to the
Remaining Amount until paid in full, then applied to the Extended Amount.”

5. Except as expressly amended hereby, the Agreement shall continue in full force and effect
as though set forth in full herein.

6. To the extent this Amendment and the Agreement conflict or are inconsistent, the terms and
conditions of this Amendment shall prevail.

EXECUTED as of the Amendment Effective Date.

BORROWER:

PACIFIC BIOMARKERS, INC.

a Delaware corporation

	 	 	 	 	 
	 	 	By:
	 	/s/ Ronald R. Helm

	 	 	 	 	 

	 	 	 	 	Ronald R. Helm

Chief Executive Officer

	LENDER:
	 	

	 	

	 	 	 	 	/s/ Terry M. Giles

	 	 	 
	 	 

	 	 	TERRY M. GILES

1

SCHEDULE A-1

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Balance brought forward on original note at 9/30/10	 	$	3,667,769.87	 
	 	 	 	 	 	 	Balance of non-extended portion at 9/30/10	 	$	2,489,279.74	 
	Paid:
	 	 	 	 	 	Payment
	 	Interest

	 	Principal
	 	Note Balance

	 
	 	 	 	 	 	 	 	 	 	 

	 	 	 	 	 	 	 	 
	10/31/2010
	 	 	1	 	 	$	84,644.68	 	 	24,892.80

	 	$	59,751.88	 	 	$	2,429,527.86	 
	11/30/2010
	 	 	2	 	 	$	84,644.68	 	 	24,295.28

	 	$	60,349.40	 	 	$	2,369,178.46	 
	12/31/2010
	 	 	3	 	 	$	84,644.68	 	 	23,691.78

	 	$	60,952.89	 	 	$	2,308,225.57	 
	1/31/2011
	 	 	4	 	 	$	84,644.68	 	 	23,082.26

	 	$	61,562.42	 	 	$	2,246,663.15	 
	2/28/2011
	 	 	5	 	 	$	84,644.68	 	 	22,466.63

	 	$	62,178.04	 	 	$	2,184,485.11	 
	3/31/2011
	 	 	6	 	 	$	84,644.68	 	 	21,844.85

	 	$	62,799.83	 	 	$	2,121,685.28	 
	4/30/2011
	 	 	7	 	 	$	84,644.68	 	 	21,216.85

	 	$	63,427.82	 	 	$	2,058,257.46	 
	5/31/2011
	 	 	8	 	 	$	84,644.68	 	 	20,582.57

	 	$	64,062.10	 	 	$	1,994,195.36	 
	6/30/2011
	 	 	9	 	 	$	84,644.68	 	 	19,941.95

	 	$	64,702.72	 	 	$	1,929,492.63	 
	7/31/2011
	 	 	10	 	 	$	84,644.68	 	 	19,294.93

	 	$	65,349.75	 	 	$	1,864,142.88	 
	8/31/2011
	 	 	11	 	 	$	84,644.68	 	 	18,641.43

	 	$	66,003.25	 	 	$	1,798,139.64	 
	9/30/2011
	 	 	12	 	 	$	84,644.68	 	 	17,981.40

	 	$	66,663.28	 	 	$	1,731,476.36	 
	10/31/2011
	 	 	13	 	 	$	84,644.68	 	 	17,314.76

	 	$	67,329.91	 	 	$	1,664,146.45	 
	11/30/2011
	 	 	14	 	 	$	84,644.68	 	 	16,641.46

	 	$	68,003.21	 	 	$	1,596,143.23	 
	12/31/2011
	 	 	15	 	 	$	84,644.68	 	 	15,961.43

	 	$	68,683.24	 	 	$	1,527,459.99	 
	1/31/2012
	 	 	16	 	 	$	84,644.68	 	 	15,274.60

	 	$	69,370.08	 	 	$	1,458,089.91	 
	2/29/2012
	 	 	17	 	 	$	84,644.68	 	 	14,580.90

	 	$	70,063.78	 	 	$	1,388,026.14	 
	3/31/2012
	 	 	18	 	 	$	84,644.68	 	 	13,880.26

	 	$	70,764.41	 	 	$	1,317,261.72	 
	4/30/2012
	 	 	19	 	 	$	84,644.68	 	 	13,172.62

	 	$	71,472.06	 	 	$	1,245,789.66	 
	5/31/2012
	 	 	20	 	 	$	84,644.68	 	 	12,457.90

	 	$	72,186.78	 	 	$	1,173,602.88	 
	6/30/2012
	 	 	21	 	 	$	84,644.68	 	 	11,736.03

	 	$	72,908.65	 	 	$	1,100,694.24	 
	7/31/2012
	 	 	22	 	 	$	84,644.68	 	 	11,006.94

	 	$	73,637.73	 	 	$	1,027,056.50	 
	8/31/2012
	 	 	23	 	 	$	84,644.68	 	 	10,270.57

	 	$	74,374.11	 	 	$	952,682.39	 
	9/30/2012
	 	 	24	 	 	$	84,644.68	 	 	9,526.82

	 	$	75,117.85	 	 	$	877,564.54	 
	10/31/2012
	 	 	25	 	 	$	84,644.68	 	 	8,775.65

	 	$	75,869.03	 	 	$	801,695.51	 
	11/30/2012
	 	 	26	 	 	$	84,644.68	 	 	8,016.96

	 	$	76,627.72	 	 	$	725,067.79	 
	12/31/2012
	 	 	27	 	 	$	84,644.68	 	 	7,250.68

	 	$	77,394.00	 	 	$	647,673.79	 
	1/31/2013
	 	 	28	 	 	$	84,644.68	 	 	6,476.74

	 	$	78,167.94	 	 	$	569,505.85	 
	2/28/2013
	 	 	29	 	 	$	84,644.68	 	 	5,695.06

	 	$	78,949.62	 	 	$	490,556.23	 
	3/31/2013
	 	 	30	 	 	$	84,644.68	 	 	4,905.56

	 	$	79,739.11	 	 	$	410,817.12	 
	4/30/2013
	 	 	31	 	 	$	84,644.68	 	 	4,108.17

	 	$	80,536.50	 	 	$	330,280.61	 
	5/31/2013
	 	 	32	 	 	$	84,644.68	 	 	3,302.81

	 	$	81,341.87	 	 	$	248,938.74	 
	6/30/2013
	 	 	33	 	 	$	84,644.68	 	 	2,489.39

	 	$	82,155.29	 	 	$	166,783.46	 
	7/31/2013
	 	 	34	 	 	$	84,644.68	 	 	1,667.83

	 	$	82,976.84	 	 	$	83,806.61	 
	8/31/2013
	 	 	35	 	 	$	84,644.68	 	 	838.07

	 	$	83,806.61	 	 	$	0.00	 

2

SCHEDULE A-2

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 Balance of extended portion at 9/30/10
	 	$	1,178,490.13	 
	Paid:
	 	 	 	 	 	Payment

	 	Interest
	 	Principal
	 	Note Balance

	 
	 	 	 	 	 	 

	 	 	 	 	 	 	 	 	 	 	 	 
	10/31/2010
	 	 	1	 	 	$20,000.00

	 	 	11,784.90	 	 	$	8,215.10	 	 	$	1,170,275.03	 
	11/30/2010
	 	 	2	 	 	$20,000.00

	 	 	11,702.75	 	 	$	8,297.25	 	 	$	1,161,977.78	 
	12/31/2010
	 	 	3	 	 	$20,000.00

	 	 	11,619.78	 	 	$	8,380.22	 	 	$	1,153,597.56	 
	1/31/2011
	 	 	4	 	 	$20,000.00

	 	 	11,535.98	 	 	$	8,464.02	 	 	$	1,145,133.54	 
	2/28/2011
	 	 	5	 	 	$20,000.00

	 	 	11,451.34	 	 	$	8,548.66	 	 	$	1,136,584.87	 
	3/31/2011
	 	 	6	 	 	$20,000.00

	 	 	11,365.85	 	 	$	8,634.15	 	 	$	1,127,950.72	 
	4/30/2011
	 	 	7	 	 	$20,000.00

	 	 	11,279.51	 	 	$	8,720.49	 	 	$	1,119,230.23	 
	5/31/2011
	 	 	8	 	 	$20,000.00

	 	 	11,192.30	 	 	$	8,807.70	 	 	$	1,110,422.53	 
	6/30/2011
	 	 	9	 	 	$20,000.00

	 	 	11,104.23	 	 	$	8,895.77	 	 	$	1,101,526.75	 
	7/31/2011
	 	 	10	 	 	$20,000.00

	 	 	11,015.27	 	 	$	8,984.73	 	 	$	1,092,542.02	 
	8/31/2011
	 	 	11	 	 	$20,000.00

	 	 	10,925.42	 	 	$	9,074.58	 	 	$	1,083,467.44	 
	9/30/2011
	 	 	12	 	 	$20,000.00

	 	 	10,834.67	 	 	$	9,165.33	 	 	$	1,074,302.12	 
	10/31/2011
	 	 	13	 	 	$20,000.00

	 	 	10,743.02	 	 	$	9,256.98	 	 	$	1,065,045.14	 
	11/30/2011
	 	 	14	 	 	$20,000.00

	 	 	10,650.45	 	 	$	9,349.55	 	 	$	1,055,695.59	 
	12/31/2011
	 	 	15	 	 	$20,000.00

	 	 	10,556.96	 	 	$	9,443.04	 	 	$	1,046,252.54	 
	1/31/2012
	 	 	16	 	 	$20,000.00

	 	 	10,462.53	 	 	$	9,537.47	 	 	$	1,036,715.07	 
	2/29/2012
	 	 	17	 	 	$20,000.00

	 	 	10,367.15	 	 	$	9,632.85	 	 	$	1,027,082.22	 
	3/31/2012
	 	 	18	 	 	$20,000.00

	 	 	10,270.82	 	 	$	9,729.18	 	 	$	1,017,353.04	 
	4/30/2012
	 	 	19	 	 	$20,000.00

	 	 	10,173.53	 	 	$	9,826.47	 	 	$	1,007,526.57	 
	5/31/2012
	 	 	20	 	 	$20,000.00

	 	 	10,075.27	 	 	$	9,924.73	 	 	$	997,601.84	 
	6/30/2012
	 	 	21	 	 	$20,000.00

	 	 	9,976.02	 	 	$	10,023.98	 	 	$	987,577.86	 
	7/31/2012
	 	 	22	 	 	$20,000.00

	 	 	9,875.78	 	 	$	10,124.22	 	 	$	977,453.64	 
	8/31/2012
	 	 	23	 	 	$20,000.00

	 	 	9,774.54	 	 	$	10,225.46	 	 	$	967,228.17	 
	9/30/2012
	 	 	24	 	 	$20,000.00

	 	 	9,672.28	 	 	$	10,327.72	 	 	$	956,900.45	 
	10/31/2012
	 	 	25	 	 	$20,000.00

	 	 	9,569.00	 	 	$	10,431.00	 	 	$	946,469.46	 
	11/30/2012
	 	 	26	 	 	$20,000.00

	 	 	9,464.69	 	 	$	10,535.31	 	 	$	935,934.15	 
	12/31/2012
	 	 	27	 	 	$20,000.00

	 	 	9,359.34	 	 	$	10,640.66	 	 	$	925,293.49	 
	1/31/2013
	 	 	28	 	 	$20,000.00

	 	 	9,252.93	 	 	$	10,747.07	 	 	$	914,546.43	 
	2/28/2013
	 	 	29	 	 	$20,000.00

	 	 	9,145.46	 	 	$	10,854.54	 	 	$	903,691.89	 
	3/31/2013
	 	 	30	 	 	$20,000.00

	 	 	9,036.92	 	 	$	10,963.08	 	 	$	892,728.81	 
	4/30/2013
	 	 	31	 	 	$20,000.00

	 	 	8,927.29	 	 	$	11,072.71	 	 	$	881,656.10	 
	5/31/2013
	 	 	32	 	 	$20,000.00

	 	 	8,816.56	 	 	$	11,183.44	 	 	$	870,472.66	 
	6/30/2013
	 	 	33	 	 	$20,000.00

	 	 	8,704.73	 	 	$	11,295.27	 	 	$	859,177.39	 
	7/31/2013
	 	 	34	 	 	$20,000.00

	 	 	8,591.77	 	 	$	11,408.23	 	 	$	847,769.16	 
	8/31/2013
	 	 	35	 	 	$20,000.00

	 	 	8,477.69	 	 	$	11,522.31	 	 	$	836,246.85	 

3

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Paid:	 	 	 	Payment	 	Interest	 	Principal	 	Note Balance
	9/30/2013	 	36	 	$20,000.00	 	8,362.47	 	$11,637.53	 	$	824,609.32	 
	10/31/2013	 	37	 	$20,000.00	 	8,246.09	 	$11,753.91	 	$	812,855.42	 
	11/30/2013	 	38	 	$20,000.00	 	8,128.55	 	$11,871.45	 	$	800,983.97	 
	12/31/2013	 	39	 	$20,000.00	 	8,009.84	 	$11,990.16	 	$	788,993.81	 
	1/31/2014	 	40	 	$20,000.00	 	7,889.94	 	$12,110.06	 	$	776,883.75	 
	2/28/2014	 	41	 	$20,000.00	 	7,768.84	 	$12,231.16	 	$	764,652.59	 
	3/31/2014	 	42	 	$20,000.00	 	7,646.53	 	$12,353.47	 	$	752,299.11	 
	4/30/2014	 	43	 	$20,000.00	 	7,522.99	 	$12,477.01	 	$	739,822.10	 
	5/31/2014	 	44	 	$20,000.00	 	7,398.22	 	$12,601.78	 	$	727,220.32	 
	6/30/2014	 	45	 	$20,000.00	 	7,272.20	 	$12,727.80	 	$	714,492.53	 
	7/31/2014	 	46	 	$20,000.00	 	7,144.93	 	$12,855.07	 	$	701,637.45	 
	8/31/2014	 	47	 	$20,000.00	 	7,016.37	 	$12,983.63	 	$	688,653.83	 
	9/30/2014	 	48	 	$20,000.00	 	6,886.54	 	$13,113.46	 	$	675,540.36	 
	10/31/2014	 	49	 	$20,000.00	 	6,755.40	 	$13,244.60	 	$	662,295.77	 
	11/30/2014	 	50	 	$20,000.00	 	6,622.96	 	$13,377.04	 	$	648,918.73	 
	12/31/2014	 	51	 	$20,000.00	 	6,489.19	 	$13,510.81	 	$	635,407.91	 
	1/31/2015	 	52	 	$20,000.00	 	6,354.08	 	$13,645.92	 	$	621,761.99	 
	2/28/2015	 	53	 	$20,000.00	 	6,217.62	 	$13,782.38	 	$	607,979.61	 
	3/31/2015	 	54	 	$20,000.00	 	6,079.80	 	$13,920.20	 	$	594,059.41	 
	4/30/2015	 	55	 	$600,000.00	 	5,940.59	 	$594,059.41	 	$	0.00	 

4EX-4.1

Exhibit 4.1

AMENDMENT NO. 4

Dated as of September 28, 2010

to

CREDIT AGREEMENT

Dated as of November 7, 2007

THIS AMENDMENT NO. 4 (“Amendment”) is made as of September 28, 2010 by and among Brush
Engineered Materials Inc. (the “Company”), the Foreign Subsidiary Borrowers from time to
time party thereto (together with the Company, the “Borrowers”), the financial institutions
listed on the signature pages hereof and JPMorgan Chase Bank, National Association, as
Administrative Agent (the “Administrative Agent”), under that certain Credit Agreement
dated as of November 7, 2007 by and among the Borrowers, the Lenders and the Administrative Agent
(as amended, supplemented or otherwise modified from time to time, the “Credit Agreement”).
Capitalized terms used herein and not otherwise defined herein shall have the respective meanings
given to them in the Credit Agreement.

WHEREAS, the Company has requested that the Lenders and the Administrative Agent agree to
certain amendments to the Credit Agreement;

WHEREAS, the Lenders party hereto and the Administrative Agent have agreed to such amendments
on the terms and conditions set forth herein;

NOW, THEREFORE, in consideration of the premises set forth above, the terms and conditions
contained herein, and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the Borrowers, the Lenders party hereto and the Administrative Agent have
agreed to enter into this Amendment.

1. Amendments to Credit Agreement. Effective as of the date of satisfaction
of the conditions precedent set forth in Section 2 below, the Credit Agreement is hereby
amended as follows:

(a) The definition of “Consolidated Funded Debt” set forth in Article 1 of the
Credit Agreement is amended to delete the reference to “$235,000,000” therein and to substitute
“$270,000,000” therefor.

(b) The definition of “Permitted Precious Metals Agreements” set forth in Article
1 of the Credit Agreement is amended to delete the reference to “$235,000,000” therein and to
substitute “$270,000,000” therefor.

(c) Clause (h) of Section 6.01 of the Credit Agreement is amended to delete the
reference to “$235,000,000” therein and to substitute “$270,000,000” therefor.

2.

Conditions of Effectiveness. The effectiveness of this Amendment is subject to
the conditions precedent that (a) the Administrative Agent shall have received (i) counterparts of
this Amendment duly executed by the Borrowers, the Required Lenders and the Administrative Agent,
(ii) counterparts of the Consent and Reaffirmation attached hereto as Exhibit A duly
executed by the Subsidiary Guarantors and (iii) for the account of each Lender which delivers its
executed signature page hereto by such time as is requested by the Administrative Agent, an
amendment fee in an amount equal to $5,000 and (b) the Company shall have paid, to the extent
invoiced, all out-of-pocket expenses of the Administrative Agent (including reasonable attorneys’
fees and expenses) in connection with this Amendment and the other Loan Documents.

3. Representations and Warranties of the Borrowers. Each Borrower hereby
represents and warrants as follows:

(a) This Amendment and the Credit Agreement, as amended hereby, constitute legal, valid and
binding obligations of such Borrower and are enforceable against such Borrower in accordance with
their terms, subject to applicable bankruptcy, insolvency, reorganization, moratorium or other laws
affecting creditors’ rights generally and subject to general principles of equity, regardless of
whether considered in a proceeding in equity or at law.

(b) As of the date hereof and giving effect to the terms of this Amendment, (i) no Default
shall have occurred and be continuing and (ii) the representations and warranties of the Borrowers
set forth in the Credit Agreement, as amended hereby, are true and correct as of the date hereof.

4. Reference to and Effect on the Credit Agreement.

(a) Upon the effectiveness hereof, each reference to the Credit Agreement in the Credit
Agreement or any other Loan Document shall mean and be a reference to the Credit Agreement as
amended hereby.

(b) Except as specifically amended above, the Credit Agreement and all other documents,
instruments and agreements executed and/or delivered in connection therewith shall remain in full
force and effect and are hereby ratified and confirmed.

(c) The execution, delivery and effectiveness of this Amendment shall not operate as a waiver
of any right, power or remedy of the Administrative Agent or the Lenders, nor constitute a waiver
of any provision of the Credit Agreement or any other documents, instruments and agreements
executed and/or delivered in connection therewith.

5. Governing Law. This Amendment shall be construed in accordance with and
governed by the law of the State of New York.

6. Headings. Section headings in this Amendment are included herein for
convenience of reference only and shall not constitute a part of this Amendment for any other
purpose.

7. Counterparts. This Amendment may be executed by one or more of the
parties hereto on any number of separate counterparts, and all of said counterparts taken together
shall be deemed to constitute one and the same instrument. Signatures delivered by facsimile or
PDF shall have the same force and effect as manual signatures delivered in person.

[Signature Pages Follow]

IN WITNESS WHEREOF, this Amendment has been duly executed as of the day and year first above
written.

BRUSH ENGINEERED MATERIALS INC., as the Company

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: VP, Treasurer and Secretary

WILLIAMS ADVANCED MATERIALS

(NETHERLANDS) B.V., as the Dutch Borrower

By: /s/ Cynthia Friedman

	 
	 	 	Name:	 	 	Cynthia Friedman
	 	 	Title: Class A Director	 
	 	 	By:	 	 	/s/ James P. Marrotte

	 
	 	 	Name:	 	 	James P. Marrotte
	 	 	Title: Class A Director	 
	 	 	By:	 	 	/s/ J. G. W. van Blokland

	 	 	Name: J. G. W. van Blokland

Title: Class B Director

1

JPMORGAN CHASE BANK, NATIONAL ASSOCIATION, individually as a
Lender, as Swingline Lender, as Issuing Bank and as
Administrative Agent

By /s/ William P. McGreehan

2

	 
	 	 	Name:	 	 	William P. McGreehan
	 	 	Title: Senior Vice President

FIFTH THIRD BANK, individually as a Lender and as
Co-Syndication Agent

	 	 	 
	By:

Name:

Title:

	 	/s/ Martin H. McGinty

Martin H. McGinty

Vice President

3

	 	 	BANK OF AMERICA, N.A., individually as a Lender and as
Co-Syndication Agent

	 	 	 
	By:

Name:

Title:

	 	/s/ Sandra Guerreri

Sandra Guerreri

Vice President

4

	 	 	RBS CITIZENS, NATIONAL ASSOCIATION, individually as a Lender
and as Co-Documentation Agent

	 	 	 
	By:

Name:

Title:

	 	/s/ Patrick F. Dunphy

Patrick F. Dunphy

Senior Vice President

5

	 	 	KEYBANK NATIONAL ASSOCIATION, individually as a Lender and as
Co-Documentation Agent

	 	 	 
	By:

Name:

Title:

	 	/s/ Marcel Fournier

Marcel Fournier

Vice President

6

	 	 	WELLS FARGO BANK, NATIONAL ASSOCIATION,

as a Lender

	 	 	 
	By:

Name:

Title:

	 	/s/ Jason W. Sutton

Jason W. Sutton

Vice President

EXHIBIT A

CONSENT AND REAFFIRMATION

Each of the undersigned hereby acknowledges receipt of a copy of the foregoing Amendment No. 4
to the Credit Agreement dated as of November 7, 2007 (as the same may be amended, restated,
supplemented or otherwise modified from time to time, the “Credit Agreement”) by and among
Brush Engineered Materials Inc. (the “Company”), the Foreign Subsidiary Borrowers from time
to time party thereto (together with the Company, the “Borrowers”), the financial
institutions from time to time party thereto (the “Lenders”) and JPMorgan Chase Bank,
National Association, as Administrative Agent (the “Administrative Agent”), which Amendment
No. 4 is dated as of September 28, 2010 (the “Amendment”). Capitalized terms used in this
Consent and Reaffirmation and not defined herein shall have the meanings given to them in the
Credit Agreement. Without in any way establishing a course of dealing by the Administrative Agent
or any Lender, each of the undersigned consents to the Amendment and reaffirms the terms and
conditions of the Subsidiary Guaranty, the Security Agreement and any other Loan Document executed
by it and acknowledges and agrees that such agreements and each and every such Loan Document
executed by the undersigned in connection with the Credit Agreement remains in full force and
effect and is hereby reaffirmed, ratified and confirmed. All references to the Credit Agreement
contained in the above-referenced documents shall be a reference to the Credit Agreement as so
modified by the Amendment and as the same may from time to time hereafter be amended, modified or
restated.

Dated: September 28, 2010

[Signature Page Follows]

	 	 	 
	BRUSH ENGINEERED MATERIALS INC. BRUSH W

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: VP, Treasurer & Secretary

	 	ELLMAN INC.

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: VP, Treasurer & Secretary
	BRUSH RESOURCES INC.

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: Treasurer

	 	WILLIAMS ADVANCED MATERIALS INC.

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: VP, Treasurer & Secretary
	TECHNICAL MATERIALS, INC.

By: /s/ Michael C. Hasychak

Name: Michael C. Hasychak

Title: VP, Treasurer & Secretary

	 	

7

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