Document:

Exhibit 10.18

 

Certain information has been omitted under a request for confidential treatment, and the omitted information has been filed with the Commission. Confidential portions are marked [**].

 

Second Amendment

to the

Sponsored  Research Agreement

 

This SECOND AMENDMENT TO THE SPONSORED  RESEARCH AGREEMENT (the "Second Amendment") is made as of the date of the last signature below (the "Second Amendment Effective Date"), by and between THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, a Pennsylvania nonprofit corporation located at 3601 Spruce Street, Philadelphia, PA 19104 ("Wistar"), and ONCOCYTE CORPORATION, a corporation organized under the laws of California, with a principal place of business located at 1301 Harbor Bay Parkway, Alameda, CA 94502 ("Sponsor"). Wistar and Sponsor shall be referred to herein individually as a "Party" and collectively as the "Parties."

 

WHEREAS, Wistar and Sponsor entered into a sponsored research agreement on September 18, 2013 to fund Dr. Louise C. Showe's research relating to the development of new molecular diagnostics for lung cancer (the "SRA");

 

WHEREAS, Sponsor has paid to Wistar two hundred fifty thousand dollars (**) under the SRA as of the First Amendment Effective Date;

 

WHEREAS, the Parties executed a first exclusive option agreement on February 20, 20 I 5 to negotiate mutually agreeable terms and conditions of an exclusive, worldwide license to practice Wistar's and the University of Pennsylvania's ("Penn") joint ownership interest in the Wistar Background Technology (the "First Option");

 

WHEREAS, the Parties executed a second exclusive option agreement on May 15, 2015 to negotiate mutually agreeable terms and conditions of an exclusive, worldwide license to practice Wistar's ownership interest in its wholly-owned Selected Inventions (the "Second Option") (the First Option and Second Option shall be collectively refered to herein as the "Options"); and

 

WHEREAS, the Parties executed a first amendment to the SRA to expand the scope of research and budget ("First Amendment"); and

 

WHEREAS, concurrent with the negotiation and contract finalization of the license agreement(s) per the Options, the Parties wish to further expand the Sponsored Research scope of work, increase the budget, and modify the payment schedule of the SRA as specified below.

 

NOW, THEREFORE, in consideration of the premises and mutual covenants contained herein, and intending to be legally bound hereby, the Parties hereto agree as follows:

 

1.         All capitalized terms not expressly defined herein shall have the same meanings assigned to them in the SRA.

 

Wistar/OncoCyte Second Amendment to the Sponsored Research Agreement

 

Page 1 of 4

Certain information has been omitted under a request for confidential treatment, and the omitted information has been filed with the Commission. Confidential portions are marked [**].

 

2.         The words "Schedule I" in Section 1.5 of the SRA shall be replaced with the words "Schedules I, III and IV" to account for the expanded scope of work and additional budget.

 

3.         The SRA shall be amended to include the attached Schedule IV.

 

4.         Aim 1 of the First Amendment has been completed. Aim 2 is being modified under this Second Amendment to the SRA. Aim 3 of the First Amendment has been deleted.

 

5.         Section 4.1 (Funding) of the SRA shall be deleted in its entirety and replaced with the following:

 

Funding. Sponsor has already paid Wistar [**] in accordance with (i) and (ii) below. Sponsor shall pay Wistar the additional amount of [**] in accordance with (iii) through (vi) below:

 

(i)             [**] shall be paid upon execution of this Agreement (received by Wistar on October 22, 2013);

 

(ii)            [**] shall be paid upon the first anniversary of this Agreement (received by Wistar on October 24, 2014);

 

(iii)          [**] shall be paid upon execution of the First Amendment (invoiced by Wistar on October 5, 201 5);

 

(iv)          [**] shall be paid upon execution of the Second Amendment;

 

(v)           [**] shall be paid upon completion of Aim I as outlined in Schedule III (invoiced by Wistar on October 12, 2015);

 

(vi)          an additional [**] shall be paid upon completion of Aim 4 as outlined in Schedule IV. Completion is defined as completing the analysis described in Aim 4 (Schedule IV) and transmission of data to OncoCyte.

 

6.         Except as expressly amended or modified herein, any and all other terms and conditions of the SRA will remain unchanged .

 

7.         Entire Agreement. This Second Amendment, the amended SRA and the Options embodies the entire understanding between the Parties relating to the subject matter thereof and supersedes all prior understandings and agreements, whether written or oral.

Wistar/OncoCyte Second Amendment to the Sponsored Research Agreement

 

Page 2 of 4

IN WITNESS WHEREOF, the duly authorized representatives of the Parties hereby execute this First Amendment as of the dates below.

 

	THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY	 	ONCOCYTE CORPORATION	 
	 	 	 	 	 	 	 	 
	
By:

	/s/Heather A. Steinman	 	 	
By:

	
/s/ William Annett

	 	 
		Heather A. Steinman, Ph.D., M.B.A.	 	 	William Annett	 
		Vice President, Business Development	 	 	
CEO OncoCyte

	 
	 	Executive Director, Technology Transfer	 	 	 	 	 
	 	 	 	 	Date:	October 18, 2015	 
	
Date:

	October 15, 2015	 			 	 

 

	
AGREED TO AND ACCEPTED BY:

	
 

	
By:

	
/s/Louise C. Showe

	 	
 

	
 

	
Louise C. Showe, Ph.D.

	
 

	
 

	
Professor

	
 

	
 

	
 

	 	
 

	
Date:

	
October 15, 2015

	
 

 

Wistar/OncoCyte Second Amendment to the Sponsored Research Agreement

 

Page 3 of 4

Certain information has been omitted under a request for confidential treatment, and the omitted information has been filed with the Commission. Confidential portions are marked [**].

SPONSORED RESEARCH AGREEMENT

 

Schedule IV

Budget to cover expanded scope of work of Aim 2 based on 10/7/2015 conference  call

 

A: Additional full-time support (100% effort) of entry level technician salary= [**]

 

B: Direct cost of [**] probe set the cost is –[**]

 

[**]

Total Cost:

 

[**]  100% effort technician

[**]

[**] overhead

 

[**]

 

Aim 4: Immunology Panel

 

[**]

Can initiate experiment right away.

 

Additional cost:

 

[**] materials cost * [**] indirect rate= [**]

 

 

Wistar/OncoCyte Second Amendment to the Sponsored Research Agreement

 

Page 4 of 4Exhibit 10.2

 

 

	August 26, 2015	$2,200.00

 

PROMISSORY NOTE

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

This Note has not been registered
under the Securities Act of 1993, as amended (the "Securities Act"), or under the provisions of any applicable state
securities laws, but has been acquired by the registered holder hereof for purposes of investment and in reliance on statutory
exemptions under the Securities Act, and under any applicable state securities laws. This Note may not be sold, pledged, transferred
or assigned except in a transaction which is exempt under provisions of the Securities Act and any applicable state securities
laws or pursuant to an effective registration statement; and in the case of an exemption, only if the Company has received
an opinion of counsel satisfactory to the Company that such transaction does not require registration of this Note.

 

Frontier
Digital Media Group, Inc.. a Colorado corporation (the "Company"), for value received, hereby promises to pay to Patrick
A. Dunda, or assign(s) (the "Holder"), on or before December 31, 2016 (the "Maturity Date"), at the offices
of Holder, the principal sum of Two Thousand Two Hundred and 00/100 Dollars ($2,200.00) in such coin or currency of the United
States of America as at the time of payment shall be legal tender for the payment of public and private debts.

 

This
Note shall be interest free until May 30, 2015, after which time it shall bear interest at the rate of 6% per annum. Interest
shall accrue and be compounded monthly and shall be payable in like coin or currency on the Maturity Date.

 

Transfers of Note
to Comply with the Securities Act

 

The Holder
agrees that this Note may not be sold, transferred, pledged or otherwise disposed of except as follows: (1) to a person who, in
the opinion of counsel to the Company, is a person to whom the Note may legally be transferred without registration and without
delivery of a current prospectus under the Securities Act with respect thereto and then only against a receipt of an agreement
of such person to comply with the provisions of this Section 1 with respect to any resale or other disposition of the Note; (2)
to any person who complies with the provisions of this Section 1 with respect to any resale or other disposition of the Note; or
(3) to any person upon the delivery of a prospectus then meeting the requirements of the Securities Act relating to such securities
and the offering thereof for such sale or disposition, and thereafter to all successive assignees.

 

1.     Prepayment.

 

The principal
amount of this Note may be prepaid by the Company, in whole or in part without premium or penalty, at any time. Upon any prepayment
of the entire principal amount of this Note, all accrued but unpaid interest shall be paid to the Holder on the date of prepayment.

 

    	1

    	 

    

 

3.     Events of Default 

 

a.     This
Note shall become due and payable immediately upon the failure by the Company to pay within five (5) days of the date due any amount
of the principal or accrued interest on this Note;

 

4.     Miscellaneous 

 

b.     This Note has been issued by the Company pursuant to authorization of the Board of Directors of the Company.

 

c.     The Company may consider and treat the person in whose name this Note shall be registered as the absolute owner thereof
for all purpose whatsoever (whether or not this Note shall be overdue) and the Company shall not be affected by any notice to the
contrary. This Note may only be transferred in accordance with Section I above. This Note is transferable only on the books of
the Company by the Holder hereof, in person or by attorney, on the surrender hereof, duly endorsed. Communications sent to any
registered owner shall be effective as against all holders or transferees of the Note not registered at the time of sending the
communication.

 

d.     Payments of principal and accmed interest shall be made to the registered owner of this Note. Payments of principal shall
be made to the registered owner of this Note upon presentation of this Note on or after maturity of this Note and its presentation
for payment.

 

e.     The Holder shall not, by virtue hereof, be entitled to any rights of a shareholder in the Company, whether at law or in
equity, and the rights of the Holder are limited to those expressed in the Note.

 

f.     This Note shall be construed and enforced in accordance with the laws of the State of Colorado.

 

g.     No recourse shall be had for the payment of the principal or interest of this Note against any incorporator or any past,
present or future shareholder, officer, director, agent or attorney of the Company, or of any successor corporation, either directly
or through the Company or any successor corporations, otherwise, all such liability of incorporators, shareholders, officers, directors,
attorneys and agents being waived, released and surrendered by the Holder hereof by the acceptance of this Note.

 

h.     The Company shall pay all costs and expenses incurred by the Holder to enforce any of the provisions of this Note, including
reasonable attorneys' fees and other expenses of collection.

 

IN WITNESS
WHEREOF, Frontier Digital Media Group, Inc.. has caused this Note to be executed in its name by its President as of the date first
set forth above.

 

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

By: /s/ Patrick A. Dunda

       Patrick
A. Dunda — President- Director

 

    	2

    	 

    

  

	August 27, 2015	$8,000.00

 

PROMISSORY NOTE

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

This Note has not been registered
under the Securities Act of 1993, as amended (the "Securities Act"), or under the provisions of any applicable state
securities laws, but has been acquired by the registered bolder hereof for purposes of investment and in reliance on statutory
exemptions under the Securities Act, and under any applicable state securities laws. This Note may not be sold, pledged, transferred
or assigned except in a transaction which is exempt under provisions of the Securities Act and any applicable state securities
laws or pursuant to an effective registration statement; and in the case of an exemption, only if the Company has received an
opinion of counsel satisfactory to the Company that such transaction does not require registration of this Note.

 

Frontier Digital
Media Group, Inc.. a Colorado corporation (the "Company"), for value received, hereby promises to pay to VentureVest
Capital Corporation, or assign(s) (the "Holder"), on or before December 31, 2016 (the "Maturity Date"), at
the offices of Holder, the principal sum of Eight Thousand and 00/100 Dollars ($8,000.00) in such coin or currency of the United
States of America as at the time of payment shall be legal tender for the payment of public and private debts.

 

This
Note shall be interest free until December 31, 2015, after which time it shall bear interest at the rate of 6% per annum. Interest
shall accrue and be compounded monthly and shall be payable in like coin or currency on the Maturity Date.

 

Transfers of Note
to Comply with the Securities Act.

 

The Holder
agrees that this Note may not be sold, transferred, pledged or otherwise disposed of except as follows: (1) to a person who, in
the opinion of counsel to the Company, is a person to whom the Note may legally be transferred without registration and without
delivery of a current prospectus under the Securities Act with respect thereto and then only against a receipt of an agreement
of such person to comply with the provisions of this Section 1 with respect to any resale or other disposition of the Note; (2)
to any person who complies with the provisions of this Section 1 with respect to any resale or other disposition of the Note; or
(3) to any person upon the delivery of a prospectus then meeting the requirements of the Securities Act relating to such securities
and the offering thereof for such sale or disposition, and thereafter to all successive assignees.

 

1.     Prepayment.

 

The principal
amount of this Note may be prepaid by the Company, in whole or in part without premium or penalty, at any time. Upon any prepayment
of the entire principal amount of this Note, all accrued but unpaid interest shall be paid to the Holder on the date of prepayment.

 

    	3

    	 

    

 

3.     Events of Default 

 

a.     This Note
shall become due and payable immediately upon the failure by the Company to pay within five (5) days of the date due any amount
of the principal or accrued interest on this Note;

 

4.     Miscellaneous 

 

b.     This Note has been issued by the Company pursuant to authorization of the Board of Directors of the Company.

 

c.     The
Company may consider and treat the person in whose name this Note shall be registered as the absolute owner thereof for all purpose
whatsoever (whether or not this Note shall be overdue) and the Company shall not be affected by any notice to the contrary. This
Note may only be transferred in accordance with Section I above. This Note is transferable only on the books of the Company by
the Holder hereof, in person or by attorney, on the surrender hereof, duly endorsed. Communications sent to any registered owner
shall be effective as against all holders or transferees of the Note not registered at the time of sending the communication.

 

d.     Payments of principal and accrued interest shall be made to the registered owner of this Note. Payments of principal shall
be made to the registered owner of this Note upon presentation of this Note on or after maturity of this Note and its presentation
for payment.

 

e.     The Holder shall not, by virtue hereof, be entitled to any rights of a shareholder in the Company, whether at law or in
equity, and the rights of the Holder are limited to those expressed in the Note.

 

f.     This Note shall be construed and enforced in accordance with the laws of the State of Colorado.

 

g.     No recourse shall be had for the payment of the principal or interest of this Note against any incorporator or any past,
present or future shareholder, officer, director, agent or attorney of the Company, or of any successor corporation, either directly
or through the Company or any successor corporations, otherwise, all such liability of incorporators, shareholders, officers, directors,
attorneys and agents being waived, released and surrendered by the Holder hereof by the acceptance of this Note.

 

h.     The Company shall pay all costs and expenses incurred by the Holder to enforce any of the provisions of this Note, including
reasonable attorneys' fees and other expenses of collection.

 

IN WITNESS
WHEREOF, Frontier Digital Media Group, Inc. has caused this Note to be executed in its name by its President as of the date first
set forth above.

 

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

By: /s/ Patrick A. Dunda

       Patrick A. Dunda — President- Director

 

    	4

    	 

    

 

	September 1, 2015	$6,500.00

 

PROMISSORY NOTE

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

This Note has
not been registered under the Securities Act of 1993, as amended (the "Securities Act"), or under the provisions of
any applicable state securities laws, but has been acquired by the registered holder hereof for purposes of investment and in
reliance on statutory exemptions under the Securities Act, and under any applicable state securities laws. This Note may not be
sold, pledged, transferred or assigned except in a transaction which is exempt under provisions of the Securities Act and any
applicable state securities laws or pursuant to an effective registration statement; and in the case of an exemption, only if
the Company has received an opinion of counsel satisfactory to the Company that such transaction does not require registration
of this Note.

 

Frontier Digital
Media Group, Inc.. a Colorado corporation (the "Company"), for value received, hereby promises to pay to VentureVest
Capital Corporation, or assign(s) (the "Holder"), on or before December 31, 2016 (the "Maturity Date"), at
the offices of Holder, the principal sum of Six Thousand Five Hundred and 00/100 Dollars ($6,500.00) in such coin or currency of
the United States of America as at the time of payment shall be legal tender for the payment of public and private debts.

 

This
Note shall be interest free until December 31, 2015, after which time it shall bear interest at the rate of 6% per annum. Interest
shall accrue and be compounded monthly and shall be payable in like coin or currency on the Maturity Date.

 

Transfers of Note
to Comply with the Securities Act.

 

The Holder agrees
that this Note may not be sold, transferred, pledged or otherwise disposed of except as follows: (1) to a person who, in the opinion
of counsel to the Company, is a person to whom the Note may legally be transferred without registration and without delivery of
a current prospectus under the Securities Act with respect thereto and then only against a receipt of an agreement of such person
to comply with the provisions of this Section 1 with respect to any resale or other disposition of the Note; (2) to any person
who complies with the provisions of this Section 1 with respect to any resale or other disposition of the Note; or (3) to any person
upon the delivery of a prospectus then meeting the requirements of the Securities Act relating to such securities and the offering
thereof for such sale or disposition, and thereafter to all successive assignees.

 

1.     Prepayment.

 

The
principal amount of this Note may be prepaid by the Company, in whole or in part without premium or penalty, at any time. Upon
any prepayment of the entire principal amount of this Note, all accrued but unpaid interest shall be paid to the Holder on the
date of prepayment.

 

    	5

    	 

    

 

3.     Events
of Default 

 

a.     This
Note shall become due and payable immediately upon the failure by the Company to pay within five (5) days of the date due any amount
of the principal or accrued interest on this Note;

 

4.     Miscellaneous 

 

b.     This
Note has been issued by the Company pursuant to authorization of the Board of Directors of the Company.

 

c.     The Company may consider and treat the person in whose name this Note shall be registered as the absolute owner thereof
for all purpose whatsoever (whether or not this Note shall be overdue) and the Company shall not be affected by any notice to the
contrary. This Note may only be transferred in accordance with Section 1 above. This Note is transferable only on the books of
the Company by the Holder hereof, in person or by attorney, on the surrender hereof, duly endorsed. Communications sent to any
registered owner shall be effective as against all holders or transferees of the Note not registered at the time of sending the
communication.

 

d.     Payments of principal and accrued interest shall be made to the registered owner of this Note. Payments of principal shall
be made to the registered owner of this Note upon presentation of this Note on or after maturity of this Note and its presentation
for payment.

 

e.     The Holder shall not, by virtue hereof, be entitled to any rights of a shareholder in the Company, whether at law or in
equity, and the rights of the Holder are limited to those expressed in the Note.

 

f.     This Note shall be construed and enforced in accordance with the laws of the State of Colorado.

 

g.     No recourse shall be had for the payment of the principal or interest of this Note against any incorporator or any past,
present or future shareholder, officer, director, agent or attorney of the Company, or of any successor corporation, either directly
or through the Company or any successor corporations, otherwise, all such liability of incorporators, shareholders, officers, directors,
attorneys and agents being waived, released and surrendered by the Holder hereof by the acceptance of this Note.

 

h.     The Company shall pay all costs and expenses incurred by the Holder to enforce any of the provisions of this Note, including
reasonable attorneys' fees and other expenses of collection.

 

IN WITNESS
WHEREOF, Frontier Digital Media Group, Inc. has caused this Note to be executed in its name by its President as of the date first
set forth above.

 

 

FRONTIER DIGITAL MEDIA GROUP, INC.

 

By: /s/ Patrick A. Dunda

       Patrick A. Dunda — President- Director

 

    	6

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