Document:

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                                                                     Exhibit 4.5

NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR
DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT OR
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF
COUNSEL FOR THE HOLDER, SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATION IS
NOT REQUIRED UNDER THE ACT OR RECEIPT OF A NO-ACTION LETTER FROM THE SECURITIES
AND EXCHANGE COMMISSION.

                       WARRANT TO PURCHASE 4,817 SHARES OF

                      SERIES A CONVERTIBLE PREFERRED STOCK

                                                     January 8, 2004

THIS CERTIFIES THAT, for value received, GENERAL ELECTRIC CAPITAL CORPORATION
("Holder") is entitled to subscribe for and purchase four thousand eight hundred
seventeen (4,817) shares of the fully paid and no assessable Series A
Convertible Preferred Stock (the "Shares" or the "Series A Preferred Stock") of
Predix Pharmaceuticals Holdings, Inc., a Delaware corporation (the "Company"),
at the Warrant Price (as hereinafter defined), pursuant to that certain
equipment lease financing agreement by and between the Holder and the Company
dated December 3, 2002, subject to the provisions and upon the terms and
conditions hereinafter set forth.

1. Warrant Price. The Warrant Price shall initially be Ten and 00/100 dollars
($10.00) per share, subject to adjustment as provided in Section 7 below.

2. Conditions to Exercise. The purchase right represented by this Warrant may be
exercised at any time, or from time to time, in whole or in part during the term
commencing on the date hereof and ending at 5:00 P.M. Pacific time on the tenth
anniversary of the date of this Warrant (the "Expiration Date").

3. Method of Exercise; Payment; Issuance of Shares; Issuance of New Warrant.

      (a) Cash Exercise. Subject to Section 2 hereof, the purchase right
represented by this Warrant may be exercised by the Holder hereof, in whole or
in part, by the surrender of this Warrant (with a duly executed Notice of
Exercise in the form attached hereto) at the principal office of the Company (as
set forth in Section 18 below) and by payment to the Company, by check, of an
amount equal to the then applicable Warrant Price per share multiplied by the
number of shares then being purchased. In the event of any exercise of the
rights represented by this Warrant, certificates for the shares of stock so
purchased shall be in the name of, and delivered to, the Holder hereof, or as
such Holder may direct (subject to the terms of transfer contained herein and
upon payment by such Holder hereof of any applicable transfer taxes). Such
delivery shall be made within 30 days after exercise of the Warrant and at the
Company's expense and, unless this Warrant has been fully exercised or expired,
a new Warrant having terms and conditions substantially identical to this
Warrant and representing the portion of the Shares, if any, with respect to
which this Warrant shall not have been exercised, shall also be issued to the
Holder hereof within 30 days after exercise of the Warrant.

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      (b) Net Issue Exercise. Holder may also elect to receive shares equal to
the value of this Warrant (or of any portion thereof remaining unexercised) by
surrender of this Warrant at the principal office of the Company together with
notice of such election, in which event the Company shall issue to Holder the
number of shares of Series A Preferred Stock computed using the following
formula:

      X = Y (A-B)
          -------
             A

      Where X = the number of shares of Series A Preferred Stock to be issued to
Holder.

      Y = the number of shares of Series A Preferred Stock purchasable under
          this Warrant (at the date of such calculation).

      A = the Fair Market Value of one share of the Series A Preferred Stock (at
          the date of such calculation).

      B = Warrant Price (as adjusted to the date of such calculation).

      (c) Fair Market Value. For purposes of this Section 3, Fair Market Value
of one share of Series A Preferred Stock shall mean:

         (i) The average of the closing bid and asked prices of the Company's
         common stock, $0.01 par value (the "Common Stock") quoted in the
         Over-The-Counter Market Summary, the last reported sale price quoted on
         the Nasdaq National Market or on any exchange on which the Common Stock
         is listed, whichever is applicable, as published in the Western Edition
         of the Wall Street Journal for the ten (10) trading days prior to the
         date of determination of Fair Market Value; or

         (ii) In the event of an exercise in connection with a merger,
         acquisition or other consolidation in which the Company is not the
         surviving entity, the per share Fair Market Value for the Stock shall
         be the value to be received per share of Series A Preferred Stock by
         all holders of the Series A Preferred Stock in such transaction as
         determined by the Board of Directors; or

         (iii) In any other instance, the per share Fair Market Value for the
         Series A Preferred Stock shall be as determined in good faith by the
         Company's Board of Directors.

         In the event of 3(c)(ii) or 3(c)(iii), above, the Company's Board of
         Directors shall prepare a certificate, to be signed by an authorized
         officer of the Company, setting forth in reasonable detail the basis
         for and method of determination of the per share Fair Market Value of
         the Stock. The Board will also certify to the Holder that this per
         share Fair Market Value will be applicable to all holders of the Series

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      A Preferred Stock. Such certification must be made to Holder at least
      thirty (30) business days prior to the proposed effective date of the
      merger, consolidation, sale, or other triggering event as defined in
      3(c)(ii) or 3(c)(iii).

   (d) Automatic Exercise. So long as the Fair Market Value of the Warrant is
equal to or greater than the Warrant Price, to the extent this Warrant is not
previously exercised, it shall be automatically exercised in accordance with
Sections 3(b) and 3(c) hereof (even if not surrendered) immediately before its
expiration, involuntary termination or cancellation.

4. Representations and Warranties of Holder and the Company.

   (a) Representations and Warranties by Holder. The Holder represents and
warrants to the Company with respect to his purchase as follows:

      (i) The Holder has substantial experience in evaluating and investing in
      private placement transactions of securities of companies similar to the
      Company so that the Holder is capable of evaluating the merits and risks
      of its investment in the Company and has the capacity to protect its
      interests.

      (ii) Except for transfer to a Holder's affiliates, the Holder is acquiring
      the Warrant and the Shares of Series A Preferred Stock issuable upon
      exercise of the Warrant (collectively the "Securities") for investment for
      its own account and not with a view to, or for resale in connection with,
      any distribution thereof. The Holder understands that the Securities have
      not been registered under the Securities Act of 1933, as amended (the
      "Act") by reason of a specific exemption from the registration provisions
      of the Act which depends upon, among other things, the bona fide nature of
      the investment intent as expressed herein.

      (iii) The Holder acknowledges that the Securities must be held
      indefinitely unless subsequently registered under the Act or an exemption
      from such registration is available. The Holder is aware of the provisions
      of Rule 144 promulgated under the Act.

      (iv) The Holder is an "accredited investor" within the meaning of
      Regulation D promulgated under the Act.

      (v) The Holder has had an opportunity to discuss the Company's business,
      management and financial affairs with its management and an opportunity to
      review the Company's facilities. The Holder understands that such
      discussions, as well as the written information issued by the Company,
      were intended to describe the aspects of the Company's business and
      prospects which the Company believes to be material but were not
      necessarily a thorough or exhaustive description.

   (b) Company hereby represents and warrants to Holder that the statements in
the following paragraphs of this Section 4(b) are true and correct as of the
date hereof.

      (i) Corporate Organization and Authority. The Company (a) is a corporation
      duly organized, validly existing, and in good standing in its jurisdiction
      of

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      incorporation, (b) has the corporate power and authority to own and
      operate its properties and to carry on its business as now conducted and
      as proposed to be conducted; and (c) is qualified as a foreign corporation
      in all jurisdictions where the failure to be so qualified would have a
      material adverse effect on the Company.

      (ii) Corporate Power. The Company has all requisite legal and corporate
      power and authority to execute, issue and deliver the Warrant, to issue
      the Series A Preferred Stock issuable upon exercise or conversion of the
      Warrant, and to carry out and perform its obligations under the Warrant
      and any related agreements.

      (iii) Authorization; Enforceability. All corporate action on the part of
      Company, its officers, directors and shareholders necessary for the
      authorization, execution, delivery and performance of its obligations
      under this Warrant and for the authorization, issuance and delivery of the
      Warrant and Stock issuable upon exercise of the Warrant has been taken and
      this Warrant constitutes the legally binding and valid obligation of
      Company enforceable in accordance with its terms.

      (iv) Valid Issuance of Warrant and Series A Preferred Stock. The Warrant
      has been validly issued and is free of restrictions on transfer other than
      restrictions on transfer set forth herein and under applicable state and
      federal securities laws. The Series A Preferred Stock issuable upon
      conversion of this Warrant, when issued, sold and delivered in accordance
      with the terms of this Warrant for the consideration expressed herein,
      will be duly and validly issued, fully paid and no assessable, and will be
      free of restrictions on transfer other than restrictions on transfer under
      this Warrant and under applicable state and federal securities laws.
      Subject to applicable restrictions on transfer, the issuance and delivery
      of the Warrant and the Series A Preferred Stock issuable upon conversion
      of the Warrant are not subject to any preemptive or other similar rights
      or any liens or encumbrances except as specifically set forth in Company's
      Certificate of Incorporation, as amended and restated to date (the
      "Certificate of Incorporation"), or this Warrant. The offer, sale and
      issuance of the Warrant and Series A Preferred Stock, as contemplated by
      this Warrant, are exempt from the prospectus and registration requirements
      of applicable United States federal and state security laws, and neither
      Company nor any authorized agent acting on its behalf has or will take any
      action hereafter that would cause the loss of such exemption.

      (v) No Conflict with Other Instruments. The execution, delivery, and
      performance of this Warrant will not result in any violation of, be in
      conflict with, or constitute a default under, with or without the passage
      of time or the giving of notice (a) any provision of Company's Certificate
      of Incorporation or by-laws; (b) any provision of any judgment, decree, or
      order to which Company is a party or by which it is bound or an event
      which results in the creation of any material lien, charge or encumbrance
      upon any material assets of Company; (c) any

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      contract, obligation, or commitment to which Company is a party or by
      which it is bound; or (d) any statute, rule, or governmental regulation
      applicable to Company.

      (vi) Capitalization. As of the date of this Warrant, the authorized and
      issued capital stock of Company is as set forth in Exhibit A. The
      outstanding shares have been duly authorized and validly issued
      (including, without limitation, issued in compliance with applicable
      federal and state securities laws), are fully paid and nonassessable and
      have been issued in compliance with the registration and prospectus
      delivery requirements of the Securities Act and the registration and
      qualification requirements of all applicable state securities laws, or in
      compliance with applicable exemptions therefrom. The Company has reserved
      4,817 shares of Series A Preferred Stock for issuance upon exercise of
      this Warrant and 48,170 shares of Common Stock for the conversion of the
      Series A Preferred Stock to Common Stock. Except as set forth on the
      capitalization table attached to this Warrant in Exhibit A, there are no
      outstanding warrants, options, conversion privileges, preemptive rights or
      other rights or agreements to purchase or otherwise acquire or issue any
      equity securities or convertible securities of Company, nor has the
      issuance of any of the aforesaid rights to acquire securities of Company
      been authorized.

      (vii) Governmental Consents. No consent, approval, order or authorization
      of, or registration, qualification, designation, declaration or filing
      with, any federal, state or local governmental authority on the part of
      Company is required in connection with the offer, sale or issuance of the
      Warrant (and the Stock issuable upon the exercise of this Warrant), or the
      consummation of any other transaction contemplated hereby, except for the
      following: (a) the filing of a notice on Form D under the Act and (b) the
      compliance with other applicable state securities laws, which compliance
      will have occurred within the appropriate time periods therefore. The
      offer, sale and issuance of the Warrant and the shares of Stock in
      conformity with the terms of this Warrant are exempt from the registration
      requirements of the Act and any applicable state laws.

   (c) Within ten (10) days of the Holder providing notice to the Company of its
intent to exercise this Warrant, the Company will deliver to the Holder an
Officer's Certificate certifying that all of the representations and warranties
set forth in this Section 4 are true and correct in all material respects as of
the date of such certificate, except for Section 4(vi), in which case the
Company will deliver to the Holder an updated capitalization table in the same
form as set forth in Appendix A and make the representations and warranties set
forth in Section 4(vi) as they relate to the updated capitalization table.

5. Legends.

   (a) Each certificate representing the Securities shall be endorsed with the
following legend:

   THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933
   AND MAY NOT BE TRANSFERRED UNLESS COVERED BY AN

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      EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT, A "NO ACTION" LETTER FROM
      THE SECURITIES AND EXCHANGE COMMISSION WITH RESPECT TO SUCH TRANSFER, A
      TRANSFER MEETING THE REQUIREMENTS OF RULE 144 OF THE SECURITIES AND
      EXCHANGE COMMISSION, OR (IF REASONABLY REQUIRED BY THE COMPANY) AN OPINION
      OF COUNSEL SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY SUCH TRANSFER
      IS EXEMPT FROM SUCH REGISTRATION.

The Company need not enter into its stock records a transfer of Securities
unless the conditions specified in the foregoing legend are satisfied. The
Company may also instruct its transfer agent not to allow the transfer of any of
the Shares unless the conditions specified in the foregoing legends are
satisfied.

      (b) Removal of Legend and Transfer Restrictions. The legend relating to
the Act endorsed on a certificate pursuant to paragraph 5(a) of this Warrant
shall be removed and the Company shall issue a certificate without such legend
to the Holder of the Securities if (i) the Securities are registered under the
Act and a prospectus meeting the requirements of Section 10 of the Act is
available or (ii) the Holder provides to the Company an opinion of counsel for
the Holder reasonably satisfactory to the Company, a no-action letter or
interpretive opinion of the staff of the SEC reasonably satisfactory to the
Company, or other evidence reasonably satisfactory to the Company, to the effect
that public sale, transfer or assignment of the Securities may be made without
registration and without compliance with any restriction such as Rule 144.

6. Condition of Transfer or Exercise of Warrant. It shall be a condition to any
transfer or exercise of this Warrant that at the time of such transfer or
exercise, the Holder shall provide the Company with a representation in writing
that the Holder or transferee is acquiring this Warrant and the shares of Stock
to be issued upon exercise for investment purposes only and not with a view to
any sale or distribution, or will provide the Company with a statement of
pertinent facts covering any proposed distribution. As a further condition to
any transfer of this Warrant or any or all of the shares of Stock issuable upon
exercise of this Warrant, other than a transfer registered under the Act, the
Company may request a legal opinion, in form and substance satisfactory to the
Company and its counsel, reciting the pertinent circumstances surrounding the
proposed transfer and stating that such transfer is exempt from the registration
and prospectus delivery requirements of the Act. The Company shall not require
Holder to provide an opinion of counsel if the transfer is to an affiliate of
Holder. Each certificate evidencing the shares issued upon exercise of the
Warrant or upon any transfer of the shares (other than a transfer registered
under the Act or any subsequent transfer of shares so registered) shall, at the
Company's option, if the Shares are not freely saleable under Rule 144(k) under
the Act, contain a legend in form and substance satisfactory to the Company and
its counsel, restricting the transfer of the shares to sales or other
dispositions exempt from the requirements of the Act. As further condition to
each transfer, at the request of the Company, the Holder shall surrender this
Warrant to the Company and the transferee shall receive and accept a Warrant, of
like tenor and date, executed by the Company.

7. Adjustment for Certain Events. If, and only if, the terms of the Series A
Preferred Stock are not otherwise adjusted in accordance with the Company's
Certificate of Incorporation, the number and kind of securities purchasable upon
the exercise of this Warrant and the Warrant

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Price shall be subject to adjustment from time to time upon the occurrence of
certain events, as follows:

      (a) Reclassification or Merger. In case of any reclassification or change
of securities of the class issuable upon exercise of this Warrant (other than a
change in par value, or from par value to no par value, or from no par value to
par value, or as a result of a subdivision or combination), or in case of any
merger of the Company with or into another corporation (other than a merger with
another corporation in which the Company is the acquiring and the surviving
corporation and which does not result in any reclassification or change of
outstanding securities issuable upon exercise of this Warrant), or in case of
any sale of all or substantially all of the assets of the Company, the Company,
or such successor or purchasing corporation, as the case may be, shall duly
execute and deliver to the Holder a new Warrant (in form and substance
satisfactory to the Holder of this Warrant), or the Company shall make
appropriate provision without the issuance of a new Warrant, so that the Holder
shall have the right to receive, at a total purchase price not to exceed that
payable upon the exercise of the unexercised portion of this Warrant, and in
lieu of the shares of Stock theretofore issuable upon exercise of this Warrant,
the kind and amount of shares of stock, other securities, money and property
receivable upon such reclassification, change, merger or sale by a Holder of the
number of shares of Stock then purchasable under this Warrant, or in the case of
such a merger or sale in which the consideration paid consists all or in part of
assets other than securities of the successor or purchasing corporation, at the
option of the Holder, the securities of the successor or purchasing corporation
having a value at the time of the transaction equivalent to the value of the
Stock purchasable upon exercise of this Warrant at the time of the transaction.
Any new Warrant shall provide for adjustments that shall be as nearly equivalent
as may be practicable to the adjustments provided for in this Section 7. The
provisions of this subparagraph (a) shall similarly apply to successive
reclassifications, changes, mergers and transfers.

      (b) Subdivision or Combination of Shares. If the Company at any time while
this Warrant remains outstanding and unexpired shall subdivide or combine its
outstanding shares of Series A Preferred Stock, the Warrant Price shall be
proportionately decreased and the number of Shares issuable hereunder shall be
proportionately increased in the case of a subdivision and the Warrant Price
shall be proportionately increased and the number of Shares issuable hereunder
shall be proportionately decreased in the case of a combination.

      (c) Stock Dividends and Other Distributions. If the Company at any time
while this Warrant is outstanding and unexpired shall (i) pay a dividend with
respect to Series A Preferred Stock payable in any shares of capital stock of
the Company, then the Warrant Price shall be adjusted, from and after the date
of determination of shareholders entitled to receive such dividend or
distribution, to that price determined by multiplying the Warrant Price in
effect immediately prior to such date of determination by a fraction (A) the
numerator of which shall be the total number of shares of Series A Preferred
Stock outstanding immediately prior to such dividend or distribution, and (B)
the denominator of which shall be the total number of shares of Series A
Preferred Stock outstanding immediately after such dividend or distribution; or
(ii) make any other distribution with respect to Series A Preferred Stock
(except any distribution specifically provided for in Sections 7(a) and 7(b)),
then, in each such case, provision shall be made by the Company such that the
Holder of this Warrant shall receive upon exercise of this warrant a
proportionate share of any such dividend or distribution as though it were the
Holder of

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the Series A Preferred Stock as of the record date fixed for the determination
of the shareholders of the Company entitled to receive such dividend or
distribution.

      (d) Adjustment of Number of Shares. Upon each adjustment in the Warrant
Price, the number of Shares purchasable hereunder shall be adjusted, to the
nearest whole share, to the product obtained by multiplying the number of Shares
purchasable immediately prior to such adjustment in the Warrant Price by a
fraction, the numerator of which shall be the Warrant Price immediately prior to
such adjustment and the denominator of which shall be the Warrant Price
immediately thereafter.

8. Notice of Adjustments. Whenever any Warrant Price or the kind or number of
securities issuable under this Warrant shall be adjusted pursuant to Section 7
hereof, the Company shall prepare a certificate signed by an officer of the
Company setting forth, in reasonable detail, the event requiring the adjustment,
the amount of the adjustment, the method by which such adjustment was
calculated, and the Warrant Price and number or kind of shares issuable upon
exercise of the Warrant after giving effect to such adjustment, and shall cause
copies of such certificate to be mailed (by certified or registered mail, return
receipt required, postage prepaid) within thirty (30) days of such adjustment to
the Holder of this Warrant as set forth in Section 17 hereof.

9. Transferability of Warrant. (a) This Warrant is transferable on the books of
the Company at its principal office by the registered Holder hereof upon
surrender of this Warrant properly endorsed, subject to compliance with Section
6 hereof and applicable federal and state securities laws. The Company shall
issue and deliver to the transferee a new Warrant representing the Warrant so
transferred. Upon any partial transfer, the Company will issue and deliver to
Holder a new Warrant with respect to the Warrant not so transferred. Holder
shall not have any right to transfer any portion of this Warrant to any direct
competitor of the Company. Notwithstanding the foregoing, although the Warrant
may be transferred more than once, this Warrant shall only be transferable so
long as any such transfer does not increase the total number of holders of this
Warrant by more than one (taking into account all prior transfers of any one
Warrant) and will not increase the total number of stockholders of the Company
by more than one (taking into account all prior transfers of any one Warrant).

      (b) Any transfer pursuant to Section 9(a) shall be effected upon surrender
of this Warrant with a properly executed assignment (in the form attached hereto
as Exhibit B) at the principal office of the Company (or, if another office or
agency has been designated by the Company for such purpose, then at such other
office or agency).

10. Registration Rights.

      (a) Whenever the Company proposes to file a Registration Statement
covering shares of Common Stock (other than a Registration Statement covering
shares: (i) to be sold solely for the account of Other Holders (as defined
below); (ii) pursuant to the initial public offering of the Company; (iii)
pursuant to a Form S-4 or Form S-8, or such similar forms; and (iv) acquired
pursuant to either (A) an acquisition of a company of which they were formerly
stockholders, (B) a "private placement" under the Act or (C) Rule 144A under the
Act) at any time and from time to time, it will, prior to such filing, give
written notice to the Holder of its intention to do so;

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provided, that no such notice need be given if none of the Holder's shares of
Common Stock underlying these Securities are to be included therein as a result
of a written notice from the managing underwriter pursuant to Section 10(b)
below. Upon the written request of the Holder given within 20 days after the
Company provides such notice (which request shall state the intended method of
disposition of such shares of Common Stock underlying the Securities), the
Company shall use its commercially reasonable efforts to cause all shares of
Common Stock underlying the Securities which the Company has been requested by
the Holder to register to be registered under the Act to the extent necessary to
permit their sale or other disposition in accordance with the intended methods
of distribution specified in the request of the Holder; provided that the
Company shall have the right to postpone or withdraw any registration effected
pursuant to this Section 10 without obligation to the Holder. For purposes of
this Section 10, "Other Holders" shall mean holders of securities of the Company
(other than the Holder) who are entitled, by contract with the Company, to have
securities included in a Registration Statement pursuant to the terms of that
certain Stockholders Agreement, dated August 8, 2003, by and among the Company
and the Stockholders, as defined therein.

      (b) If the registration for which the Company gives notice pursuant to
Section 10(a) is a registered public offering involving an underwriting, the
Company shall so advise the Holder as a part of the written notice given
pursuant to Section 10(a). In such event, (i) the right of the Holder to include
its Securities in such registration pursuant to this Section 10 shall be
conditioned upon the Holder's participation in such underwriting on the terms
set forth herein and (ii) the Holder including Securities in such registration
shall enter into an underwriting agreement upon customary terms with the
underwriter or underwriters selected for the underwriting by the Company. If the
Holder disapproves of the terms of the underwriting, the Holder may elect, by
written notice to the Company, to withdraw its shares from such Registration
Statement and underwriting. If the managing underwriter advises the Company in
writing that marketing factors require a limitation on the number of shares to
be underwritten, and subject to the superior rights, if any, of the Other
Holders and any other holder of the Company's capital stock then outstanding,
which other holders shall by virtue of such superior rights receive preference
over the Holder (the "Superior Rights Holders"), the shares held by the Holder
shall be excluded from such Registration Statement and underwriting to the
extent deemed advisable by the managing underwriter, and, if a further reduction
of the number of shares is required, and, subject to the rights of Superior
Rights Holders, if any, the number of shares that may be included in such
Registration Statement and underwriting shall be allocated first to the Company,
then to the Other Holders requesting registration in proportion, as nearly as
practicable, to the respective number of shares of Common Stock (on an
as-converted basis) held by them on the date the Company gives the notice
specified in Section 10(a) above, and then to the Holder. If any Holder or Other
Holder would thus be entitled to include more shares than such holder requested
to be registered, the excess shall be allocated among other requesting Holders
and Other Holders pro rata in the manner described in the preceding sentence.

11. No Fractional Shares. No fractional share of Series A Preferred Stock will
be issued in connection with any exercise hereunder, but in lieu of such
fractional share the Company shall make a cash payment therefor upon the basis
of the Warrant Price then in effect.

12. Charges, Taxes and Expenses. Issuance of certificates for shares of Series A
Preferred Stock upon the exercise of this Warrant shall be made without charge
to the Holder for any

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United States or state of the United States documentary stamp tax or other
incidental expense with respect to the issuance of such certificate, all of
which taxes and expenses shall be paid by the Company, and such certificates
shall be issued in the name of the Holder.

13. No Shareholder Rights Until Exercise. This Warrant does not entitle the
Holder hereof to any voting rights or other rights as a shareholder of the
Company prior to the exercise hereof.

14. Registry of Warrant. The Company shall maintain a registry showing the name
and address of the registered Holder of this Warrant. This Warrant may be
surrendered for exchange or exercise, in accordance with its terms, at such
office or agency of the Company, and the Company and Holder shall be entitled to
rely in all respects, prior to written notice to the contrary, upon such
registry.

15. Loss, Theft, Destruction or Mutilation of Warrant. Upon receipt by the
Company of evidence reasonably satisfactory to it of the loss, theft,
destruction or mutilation of this Warrant, and, in the case of loss, theft, or
destruction, of indemnity reasonably satisfactory to it, and, if mutilated, upon
surrender and cancellation of this Warrant, the Company will execute and deliver
a new Warrant, having terms and conditions substantially identical to this
Warrant, in lieu hereof.

16. Miscellaneous.

      (a) Issue Date. The provisions of this Warrant shall be construed and
shall be given effect in all respect as if it had been issued and delivered by
the Company on the date hereof.

      (b) Successors. This Warrant shall be binding upon any successors or
assigns of the Company.

      (c) Governing Law. This Warrant shall be governed by and construed in
accordance with the laws of the General Corporation Law of the State of Delaware
as to matters within in the scope thereof, and as to all other matters shall be
governed by and construed in accordance with the internal laws of the
Commonwealth of Massachusetts (without reference to the conflicts of law
provisions thereof).

      (d) Headings. The headings used in this Warrant are used for convenience
only and are not to be considered in construing or interpreting this Warrant.

      (e) Saturdays, Sundays, Holidays. If the last or appointed day for the
taking of any action or the expiration of any right required or granted herein
shall be a Saturday or a Sunday or shall be a legal holiday in the Commonwealth
of Massachusetts, then such action may be taken or such right may be exercised
on the next succeeding day not a legal holiday.

      (f) Waiver of Jury Trial. Each of the parties hereto hereby waives to the
fullest extent permitted by applicable law, any right it may have to a trial by
jury in respect of any litigation directly or indirectly arising out of, under
or in connection with this Warrant or the Shares.

      (g) Attorney's Fees. In the event of any dispute between the parties
concerning the terms and provisions of this Warrant, the party prevailing in
such dispute shall be entitled to

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collect from the other party all costs incurred in such dispute, including
reasonable attorney's fees.

17. No Impairment. The Company will not, by amendment of its Certificate of
Incorporation or any other voluntary action, avoid or seek to avoid the
observance or performance of any of the terms of this Warrant, but will at all
times in good faith assist in the carrying out of all such terms and in the
taking of all such action as may be necessary or appropriate in order to protect
the rights of the Holders hereof against impairment.

18. Addresses. Any notice required or permitted hereunder shall be in writing
and shall be mailed by overnight courier, registered or certified mail, return
receipt required, and postage prepaid, or otherwise delivered by hand or by
messenger, addressed as set forth below, or at such other address as the Company
or the Holder hereof shall have furnished to the other party.

                   If to the Company:     Predix Pharmaceuticals Holdings, Inc.
                                          10-K Gill Street
                                          Woburn, MA 01801
                                          Attn: Dr. Michael Kaufmann
                                          Chief Executive Officer

                   If to the Holder:      General Electric Capital Corporation
                                          401 Merritt 7, Suite 23
                                          Norwalk, CT 06851-1177
                                          Attn: Credit Manager

                                       11
<PAGE>

IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its
officers thereunto duly authorized.

Dated as of January 8, 2004

                                            PREDIX PHARMACEUTICALS
                                            HOLDINGS, INC.

                                            By: /s/ NJG HAYES
                                                ------------------

                                            Name: NJG Hayes

                                            Title: Chief Financial Officer

                                       12
<PAGE>

                               NOTICE OF EXERCISE

TO: Predix Pharmaceuticals Holdings, Inc.
    10-K Gill Street
    Woburn, MA  01801

    The undersigned Warrant holder ("Holder") elects to acquire shares of Series
A convertible preferred stock, $0.01 par value (the "Series A Preferred Stock"),
of Predix Pharmaceuticals Holdings, Inc. (the "Company"), pursuant to the terms
of the Stock Purchase Warrant dated _________, 2004 (the "Warrant").

1.  The Holder exercises its rights under the Warrant as set forth below
   (check one):

            ( )   The Holder elects to purchase ___________ shares of Preferred
                  Stock as provided in Section 3(a) and tenders herewith a
                  check in the amount of $______________ as payment of the
                  purchase price.

            ( )   The Holder elects to convert the purchase rights into shares
                  of Series A Preferred Stock as provided in Section 3(b) of the
                  Warrant.

2.  The Holder surrenders the Warrant with this Notice of Exercise.

The Holder represents that it is acquiring the aforesaid shares of Series A
Preferred Stock for investment and not with a view to or for resale in
connection with distribution and that the Holder has no present intention of
distributing or reselling the shares.

Please issue a certificate representing the shares of the Series A Preferred
Stock in the name of the Holder or in such other name as is specified below:

            Name:
            Address:

            Taxpayer I.D.:

                                       GENERAL ELECTRIC CAPITAL CORPORATION

                                       By:__________________________________

                                       Title:_______________________________

                                       Date:________________________________

<PAGE>

                                                                       EXHIBIT B

                                 ASSIGNMENT FORM

            FOR VALUE RECEIVED, __________________________ hereby sells, assigns
and transfers all of the rights of the undersigned under the attached Warrant
(No.______________) with respect to the number of shares of capital stock of
Predix Pharmaceuticals Holdings, Inc. covered thereby set forth below, unto:

<TABLE>
<CAPTION>
Name of Assignee           Address                         No. of Shares
----------------           -------                         -------------
<S>                        <C>                             <C>
</TABLE>

Dated:______________________________________      Signature:____________________
Signature Guaranteed:
By:_________________________________________<PAGE>

                                                                     Exhibit 4.6

      THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, ASSIGNED OR TRANSFERRED
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, UNLESS THE COMPANY HAS RECEIVED THE WRITTEN
OPINION OF COUNSEL SATISFACTORY TO THE COMPANY TO THE EFFECT THAT SUCH SALE,
ASSIGNMENT OR TRANSFER DOES NOT INVOLVE A TRANSACTION REQUIRING REGISTRATION OF
SUCH SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED.

Issue Date: November 7, 1997                                 Right to Purchase
Void After: June 30, 2007                                    100,000 Shares

                             PHYSIOME SCIENCES, INC.
                                     WARRANT

      THIS CERTIFIES that, for value received, Oxford Bioscience Management
Partners II (the "Holder") is entitled, upon the terms and subject to the
conditions hereinafter set forth, to subscribe for and purchase from Physiome
Sciences, Inc., a Delaware corporation (the "Company"), the number of fully paid
and nonassessable shares of the Company's Common Stock set forth in the caption
of this Warrant. The Exercise Price per share of the Common Stock that may be
purchased upon the exercise of this Warrant shall be $0.25 per share.

      1. EXERCISE PERIOD - The purchase rights represented by this Warrant are
exercisable by the Holder, in whole or in part, at any time from time to time
during the Exercise Period, which shall commence at 12:00 noon New York time on
the Issue Date set forth in the caption of this Warrant and shall end at 5:00
p.m. New York time on June 30, 2007.

      2. EXERCISE OF WARRANT

            (a) During the Exercise Period and provided this Warrant has not
been terminated, this Warrant shall be exercised, in whole or in part and from
time to time, by the surrender of this Warrant and the Notice of Exercise
annexed hereto duty executed at the principal office of the Company (or such
other office or agency of the Company as it may designate) and upon payment of
the Exercise Price of the shares thereby purchased. Payment of the Exercise
Price may be made (i) by check or bank draft payable to the order of the
Company, (ii) by cancellation of indebtedness of the Company to the Holder
hereof at the time of exercise, (iii) by cancellation as of the date of exercise
of a portion of this Warrant (calculated at the net fair market value of such
cancelled portion at the time of exercise), or (iv) by any combination of the
foregoing. The net fair market value of any portion of this Warrant cancelled in
full or partial payment of the Exercise Price shall be determined by (x)
multiplying (a) the number of shares of Common Stock for which the portion of
this Warrant to be cancelled was exercisable by (b) the fair market value of a
share of Common Stock as of the close of trading on the date of cancellation and
(y) subtracting from such product the aggregate Exercise Price of the shares of
Common Stock for which the portion of this Warrant to be cancelled was
exercisable. For purposes of this

<PAGE>

calculation, the fair market value of a share of Common Stock as of any date
shall be the average of the last reported sales prices for the thirty (30)
business days prior to exercise on the Nasdaq National Market or the exchange
where the Common Stock is primarily traded or, if the Common Stock is not traded
on the Nasdaq National Market or an exchange, the Common Stock shall be valued
at the closing bid price (or average of bid prices) on such date as reported by
an established quotation service for over-the-counter securities, or if the
Common Stock is not publicly traded, the Common Stock shall be valued by the
Company's Board of Directors in good faith, based upon all relevant factors,
including, without limitation, the current financial position and current and
historical operating results of the Company and sales prices of recent public
and private transactions in the Common Stock. If the amount of the payment
received by the Company is less than the Exercise Price, the Holder will be
notified of the deficiency and shall make payment in that amount within three
days. In the event the payment exceeds the Exercise Price, the Company will
refund the excess to the holder within three days of receipt. Upon exercise, the
Holder shall be entitled to receive, promptly after payment in full, one or more
certificates, issued in the Holder's name or in such name or names as the Holder
may direct, subject to the limitations on transfer contained herein, for the
number of shares of Common Stock so purchased. The shares so purchased shall be
deemed to be issued as of the close of business on the date on which this
Warrant shall have been exercised.

      The Company covenants that all shares of Common Stock that are issued upon
the exercise of rights represented by this Warrant (the "Warrant Shares") will
be fully paid, nonassessable, and free from all taxes, liens and charges in
respect of the issue thereof (other than taxes in respect of any transfer
occurring contemporaneously with such issue).

            (b) This Warrant shall be exercisable for all or any portion of the
Warrant Shares upon the reorganization, consolidation or merger of the Company
with another corporation after which the Company is not the surviving entity, or
a sale or other transfer of all or substantially all of the Company's assets to
another corporation. The Company shall give ten days' written notice to the
Holder on the effective date of any transaction described in the preceding
sentence in accordance with Section 12 hereof, in order to permit the Holder to
exercise this Warrant by such date. This Warrant shall be terminated if not
exercised by Holder upon the effective date of any such reorganization, merger,
consolidation and/or sale or other transfer of assets.

      3. NO FRACTIONAL SHARES OR SCRIP - No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of this
Warrant. In lieu thereof, a cash payment shall be made equal to such fraction
multiplied by the Exercise Price per share as then in effect.

      4. CHARGES, TAXES AND EXPENSES - Issuance of certificates for Warrant
Shares shall be made without charge to the Holder for any issue or transfer tax
or other incidental expense in respect of the issuance of such certificate, all
of which taxes and expenses shall be paid by the Company.

<PAGE>

      5. NO RIGHTS AS SHAREHOLDER - This Warrant does not entitle the Holder to
any voting rights or other rights as a shareholder of the Company prior to
exercise and payment of the Exercise Price in accordance with Section 2 hereof.

      6. INVESTMENT REPRESENTATION - The Holder, by acceptance of this Warrant,
represents and warrants to the Company that this Warrant and all securities
acquired upon any and all exercises of this Warrant are purchased for the
Holder's own account for investment, and not with view to resale or distribution
of either this Warrant or any securities purchasable upon exercise hereof.

      7. SALE OR TRANSFER OF THE WARRANT; LEGEND - Neither this Warrant nor the
Warrant Shares may be sold or transferred unless either (i) they first shall
have registered under the Securities Act of 1933, as amended (the "1933 Act")
and any applicable state securities laws, or (ii) the Company first shall have
been furnished with an opinion of legal counsel reasonably satisfactory to the
Company to the effect that such sale or transfer is exempt from the registration
requirements of the 1933 Act and such state laws. Each certificate representing
any Warrant or any Warrant Shares that has not been registered and that has not
been sold pursuant to an exemption that permits removal of the legend shall bear
a legend referring to such restrictions on transfer, substantially in the form
of the legend affixed to this Warrant. Upon the request of a holder of a
certificate representing any Warrant or any Warrant Shares, the Company shall
remove the foregoing legend from the certificate or issue to such holder a new
certificate therefor free of any transfer legend, if, with such request, the
Company shall have received either (i) an opinion of counsel reasonably
satisfactory to the Company to the effect that such legend may be removed from
such certificate or (ii) if Paragraph (k) of Rule 144 or a substantially similar
successor rule remains in force and effect, representations from the Holder that
such Holder is not then, and has not been during the preceding three months, an
affiliate of the Company and that such Holder has beneficially owned the
security (within the meaning of Rule 144) for two years or more.

      8. ADJUSTMENTS

            8.1 ADJUSTMENTS FOR STOCK SPLITS, REVERSE STOCK SPLITS OR STOCK
DIVIDENDS - In the event that the outstanding shares of Common Stock shall be
subdivided (split), combined (reverse split), by reclassification or otherwise,
or in the event of any dividend payable on the Common Stock in shares of Common
Stock, the number of shares of Common Stock available for purchase in effect
immediately prior to such subdivision, combination, or dividend shall be
proportionately adjusted.

            8.2 ADJUSTMENT FOR CAPITAL REORGANIZATIONS - If at any time there
shall be a capital reorganization of the Company or a merger or consolidation of
the Company with or into another corporation, or the sale of the Company's
properties and assets as, or substantially as, an entirety to any other person,
then, as part of such reorganization, merger, consolidation, or sale, lawful
provision shall be made so that the Holder of this Warrant shall thereafter be
entitled to receive on exercise of this Warrant during the period specified in
this Warrant and on payment of the Exercise Price then in effect, the number of
shares of stock or other securities or property of the Company, or of the
successor corporation

<PAGE>

resulting from such merger or consolidation, to which a holder of the Common
Stock deliverable on exercise of this Warrant would have been entitled on such
capital reorganization, merger, consolidation, or sale if this Warrant had been
exercised immediately before that capital reorganization, merger, consolidation,
or sale. In any such case, appropriate adjustment, as determined in good faith
by the Board of Directors of the Company, shall be made in the application of
the provisions of this Warrant with respect to the rights and interests of the
Holder of this Warrant after the reorganization, merger, consolidation, or sale
to the end that the provisions of this Warrant (including adjustment of the
number of shares purchasable on exercise of this Warrant) shall be applicable
after that event, as near as reasonably may be, in relation to any shares or
other securities or property deliverable after that event on exercise of this
Warrant.

      8.3 CERTIFICATE AS TO ADJUSTMENTS - Upon the occurrence of each adjustment
or readjustment pursuant to this Section 8, the Company at its expense shall
promptly compute such adjustment or readjustment in accordance with the terms
hereof and furnish to each Holder a certificate setting forth such adjustment or
readjustment and showing in detail the facts upon which such adjustment or
readjustment is based. The Company shall, upon the written request, at any time,
of any Holder, furnish or cause to be furnished to such Holder, a like
certificate setting forth: (i) such adjustments and readjustments; (ii) the
Exercise Price at the time in effect; and (iii) the number of shares of Common
Stock and the amount, if any, of other property that at the time would be
received upon the exercise of the Warrant.

      8.4 NOTICES OF RECORD DATE - In the event of any taking by the Company of
a record of the holders of any class of securities for the purpose of
determining the holders thereof who are entitled to receive any dividend (other
than a cash dividend that is the same as cash dividends paid in previous
quarters) or other distribution, the Company shall mail to each Holder at least
ten days prior to the date specified for the taking of a record, a notice
specifying the date on which any such record is to be taken for the purpose of
such dividend or distribution.

      9. RESERVATION OF STOCK ISSUABLE ON EXERCISE OF WARRANT - The Company will
at all times reserve and keep available, solely for issuance and delivery upon
the exercise of this Warrant, all shares of Common Stock (or other securities)
from time to time issuable upon the exercise of this Warrant.

      10. LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT - Upon receipt by
the Company of evidence reasonably satisfactory to it of the loss, theft,
destruction, or mutilation of this Warrant, and in case of loss, theft, or
destruction, of indemnity or security reasonably satisfactory to it, and upon
reimbursement to the Company of all reasonable expenses incidental thereto, and
upon surrender and cancellation of this Warrant, if mutilated, the Company will
make and deliver a new warrant of like tenor and dated as of such cancellation
in lieu of this Warrant.

      11. REMEDIES - The Company stipulates that the remedies at law of the
holder of this Warrant in the event of any default or threatened default by the
Company in the performance of or compliance with any of the terms of this
Warrant are not adequate and

<PAGE>

may be enforced by a decree for the specific performance of any agreement
contained herein or by an injunction against a violation of any of the terms
hereof or otherwise.

      12. NOTICES, ETC. - All notices and other communications from the Company
to the holder of this Warrant shall be mailed, by first class mail, to such
address as may have been furnished to the Company in writing by such holder, or,
until an address is so furnished, to and at the address of the last holder of
this Warrant who has so furnished an address to the Company. All communications
from the holder of this Warrant to the Company shall be mailed by first class
mail to the Company at it principal business address, or such other address as
may have been furnished to the holder in writing by the Company.

      13. MISCELLANEOUS - This Warrant shall be construed and enforced in
accordance with and governed by the laws of the State of Delaware. The headings
in this Warrant are for purposes of reference only, and shall not limit or
otherwise affect any of the terms hereof.

      IN WITNESS WHEREOF, the Company has caused this Warrant to be executed in
its corporate name by its duly authorized officer and to be dated as of the
issue date set forth on the first page of this Warrant.

                                               PHYSIOME SCIENCES, INC.

                                               By: /s/ WILLIAM A. SCOTT
                                                   --------------------
                                               President

(CORPORATE SEAL]

Attest:

/s/ DONNA ROUNDS
----------------
Secretary

<PAGE>

                          NOTICE OF EXERCISE OF WARRANT

TO: Physiome Sciences, Inc.

      (1) Pursuant to the terms of the attached Warrant, the undersigned hereby
elects to purchase ______________ shares of ______________ Stock of Physiome
Sciences, Inc. (the "Company"), and either (i) tenders herewith payment of the
Exercise Price of such shares in full or (ii) by indicating "cashless exercise"
below, directs that payment of the Exercise Price be made by cancellation as of
the date of exercise of a portion of this Warrant having a net fair market value
equal to the Exercise Price.

      (2) Please issue a certificate or certificates representing said shares of
Common Stock, in the name of the undersigned or in such other name(s) as is/are
specified immediately below or, if necessary, on an attachment hereto:

<TABLE>
<CAPTION>
                NAME                          ADDRESS
                ----                          -------
                <S>                           <C>
</TABLE>

      (3) In the event of partial exercise, please reissue an appropriate
Warrant exercisable into the remaining shares.

DATE:____________________                    HOLDER:____________________

Check here if cashless exercise:_____________________

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