Document:

exv10w5

Exhibit 10.5

EXECUTION COPY

#42352696v5

LEASE

BETWEEN

PDM UNIT 850, LLC

AND

ALKERMES, INC.

FOR PREMISES LOCATED AT

850 AND 852 WINTER STREET

RESERVOIR WOODS, WALTHAM, MASSACHUSETTS

 

 

TABLE OF CONTENTS

	 	 	 	 	 
	 	 	Page	 
	Article 1. Premises — Term of Lease
	 	 	1	 
	 
	Section 1.01. Premises
	 	 	1	 
	 
	Section 1.02. Special Appurtenant Rights
	 	 	2	 
	 
	Section 1.03. Term Commencement
	 	 	3	 
	 
	Article 2. Rent
	 	 	5	 
	 
	Section 2.01. Base Rent
	 	 	5	 
	 
	Section 2.02. Additional Rent for Operating Expenses and Taxes
	 	 	6	 
	 
	Section 2.03. Payment of Rent
	 	 	14	 
	 
	Section 2.04. Rent from Real Property
	 	 	14	 
	 
	Section 2.05. Security Deposit
	 	 	15	 
	 
	Article 3. Utility Services
	 	 	17	 
	 
	Section 3.01. Electricity
	 	 	17	 
	 
	Section 3.02. Other Landlord Services
	 	 	17	 
	 
	Section 3.03. Facilities Management Rights
	 	 	18	 
	 
	Article 4. Insurance
	 	 	20	 
	 
	Section 4.01. Compliance with Property Insurance
	 	 	20	 
	 
	Section 4.02. Tenant’s Required Insurance
	 	 	20	 
	 
	Section 4.03. Landlord’s Required Insurance
	 	 	22	 
	 
	Section 4.04. Tenant Work Insurance
	 	 	22	 
	 
	Section 4.05. Waiver of Subrogation
	 	 	22	 
	 
	Section 4.06. Certificates of Insurance
	 	 	22	 
	 
	Article 5. Use of Premises
	 	 	23	 
	 
	Section 5.01. Permitted Use
	 	 	23	 
	 
	Section 5.02. Tenant’s Conduct; Hazardous Materials
	 	 	23	 
	 
	Section 5.03. Hazardous Materials Indemnity
	 	 	27	 
	 
	Section 5.04. Rules and Regulations
	 	 	27	 
	 
	Article 6. Compliance with Legal Requirements
	 	 	28	 
	 
	Section 6.01. Compliance with Legal Requirements
	 	 	28	 
	 
	Article 7. Construction, Condition, Repairs and Maintenance of Premises
	 	 	28	 
	 
	Section 7.01. Base Building Work
	 	 	28	 
	 

 -i-

 

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 
	 	 	Page	 
	Section 7.02. Finish Work
	 	 	29	 
	 
	Section 7.03. Landlord Maintenance Obligations
	 	 	29	 
	 
	Section 7.04. Tenant Maintenance Obligations
	 	 	30	 
	 
	Section 7.05. Landlord’s Right of Entry
	 	 	30	 
	 
	Section 7.06. Service Interruptions
	 	 	30	 
	 
	Article 8. Alterations and Additions
	 	 	31	 
	 
	Section 8.01. Tenant Work
	 	 	31	 
	 
	Article 9. Discharge of Liens
	 	 	33	 
	 
	Section 9.01. No Liens
	 	 	33	 
	 
	Article 10. Subordination
	 	 	33	 
	 
	Section 10.01. Lease Subordinate to Mortgages
	 	 	33	 
	 
	Section 10.02. Estoppel Certificates
	 	 	35	 
	 
	Section 10.03. Notices to Mortgagees
	 	 	36	 
	 
	Section 10.04. Assignment of Rents
	 	 	36	 
	 
	Article 11. Fire, Casualty and Eminent Domain
	 	 	37	 
	 
	Section 11.01. Rights to Terminate the Lease
	 	 	37	 
	 
	Section 11.02. Restoration Obligations
	 	 	38	 
	 
	Article 12. Indemnification
	 	 	38	 
	 
	Section 12.01. General Indemnity
	 	 	38	 
	 
	Section 12.02. Defense Obligations
	 	 	39	 
	 
	Article 13. Mortgages, Assignments and Subleases by Tenant
	 	 	39	 
	 
	Section 13.01. Right to Transfer
	 	 	39	 
	 
	Section 13.02. Tenant Remains Bound
	 	 	42	 
	 
	Article 14. Default
	 	 	42	 
	 
	Section 14.01. Events of Default
	 	 	42	 
	 
	Section 14.02. Landlord’s Right to Cure
	 	 	44	 
	 
	Section 14.03. No Waiver
	 	 	44	 
	 
	Section 14.04. Late Payments
	 	 	45	 
	 
	Section 14.05. Remedies Cumulative
	 	 	45	 
	 
	Section 14.06. Landlord’s Obligation to Make Payments
	 	 	45	 
	 
	Section 14.07. Landlord Defaults
	 	 	45	 

 -ii-

 

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 
	 	 	Page	 
	Article 15. Surrender
	 	 	47	 
	 
	Section 15.01. Obligation to Surrender
	 	 	47	 
	 
	Section 15.02. Holdover Remedies
	 	 	47	 
	 
	Section 15.03. Decommissioning
	 	 	47	 
	 
	Section 15.04. Failure to Decommission
	 	 	48	 
	 
	Article 16. Quiet Enjoyment
	 	 	49	 
	 
	Section 16.01. Covenant of Quiet Enjoyment
	 	 	49	 
	 
	Article 17. Acceptance of Surrender
	 	 	49	 
	 
	Section 17.01. Acceptance of Surrender
	 	 	49	 
	 
	Article 18. Notices
	 	 	49	 
	 
	Section 18.01. Means of Giving Notice
	 	 	49	 
	 
	Article 19. Separability of Provisions
	 	 	50	 
	 
	Section 19.01. Severability
	 	 	50	 
	 
	Article 20. Miscellaneous
	 	 	50	 
	 
	Section 20.01. Amendments
	 	 	50	 
	 
	Section 20.02. Governing Law
	 	 	50	 
	 
	Section 20.03. Counterparts
	 	 	50	 
	 
	Section 20.04. Successors and Assigns
	 	 	51	 
	 
	Section 20.05. Merger Clause
	 	 	51	 
	 
	Section 20.06. Notice of Lease
	 	 	51	 
	 
	Section 20.07. No Lease
	 	 	51	 
	 
	Section 20.08. Reimbursements
	 	 	51	 
	 
	Section 20.09. Financial Statements
	 	 	51	 
	 
	Section 20.10. Parking
	 	 	52	 
	 
	Section 20.11. Future Development
	 	 	52	 
	 
	Section 20.12. Signage
	 	 	53	 
	 
	Section 20.13. Brokers
	 	 	54	 
	 
	Section 20.14. Force Majeure
	 	 	54	 
	 
	Section 20.15. Limitations on Liability
	 	 	54	 
	 
	Section 20.16. Certain Definitions
	 	 	54	 
	 
	Section 20.17. Prevailing Parties
	 	 	54	 

 -iii-

 

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 
	 	 	Page	 
	Section 20.18. Waiver of Trial by Jury
	 	 	55	 
	 
	Section 20.19. Landlord’s Reserved Rights
	 	 	55	 
	 
	Section 20.20. Tenant as non-Specially Designated National or Blocked Person
	 	 	55	 
	 
	Section 20.21. Authority
	 	 	56	 
	 
	Section 20.22. Environmental Representation
	 	 	56	 
	 
	Article 21. Rooftop License
	 	 	56	 
	 
	Section 21.01. Rooftop License
	 	 	56	 
	 
	Section 21.02. Installation and Maintenance of Rooftop Equipment
	 	 	57	 
	 
	Section 21.03. Indemnification
	 	 	57	 
	 
	Section 21.04. Removal of Rooftop Equipment
	 	 	58	 
	 
	Section 21.05. Interference by Rooftop Equipment
	 	 	58	 
	 
	Section 21.06. Relocation of Rooftop Equipment
	 	 	59	 
	 
	Article 22. Extension Options
	 	 	59	 
	 
	Section 22.01. Option to Extend
	 	 	59	 
	 
	Section 22.02. Extension Rent
	 	 	60	 
	 
	Section 22.03. Market Rent
	 	 	60	 
	 
	Section 22.04. Tenant’s Right to Dispute Market Rent
	 	 	60	 
	 
	Section 22.05. Arbitration of Market Rent
	 	 	61	 
	 
	Article 23. Right of First Refusal
	 	 	62	 
	 
	Section 23.01. Right of First Refusal
	 	 	62	 
	 
	Article 24. Right of First Offer
	 	 	64	 
	 
	Section 24.01. Right of First Offer
	 	 	64	 
	 
	Article 25. Expansion Option
	 	 	65	 
	 
	Section 25.01. Expansion Option
	 	 	65	 

 -iv-

 

 

TABLE OF CONTENTS

Page

LEASE

     LEASE dated as of April 22, 2009, by and between PDM 850 Unit, LLC, a Delaware limited
liability company (hereinafter called “Landlord”), and Alkermes, Inc., a Pennsylvania
corporation (hereinafter called “Tenant”).

Article 1.

Premises — Term of Lease

     Section 1.01. Premises. Upon and subject to the conditions and limitations
hereinafter set forth, Landlord does hereby lease and demise unto Tenant on an “as is” basis
(except as otherwise expressly set forth herein) a portion of each of the lower level, first
(including the main lobby and entryway serving the Premises), second, and third floors of a
building with an address of 850 and 852 Winter Street, Waltham, Massachusetts and constructed
substantially in accordance with the specifications attached as Exhibit 1.01-3, subject to
reasonably equivalent substitutions for materials described therein (such building being referred
to herein as the “Building”), as such demised premises is more particularly described on
Exhibit 1.01-1 (the “Premises”), together with the right to use, in common with
others, the walkways, driveways, parking areas, loading areas, and utility lines (including
telecommunications lines) serving the Premises. The parties agree that the rentable area for the
Premises is 100,235 rentable square feet, as measured in accordance with the measurement standard
described on Exhibit 1.01-4, attached.

     The Building is a condominium unit within the Reservoir Woods Primary Condominium (the
“Condominium”), a condominium created by Master Deed dated February 26, 2007, recorded in
Book 49037, Page 229 of the Middlesex South Registry of Deeds, as amended. The Building and its
undivided interest in the common elements of the Condominium are referred to herein as the
“Property” and are more particularly described on Exhibit 1.01-2. This Lease, and
Tenant’s leasehold interest in the Premises, are subject to the terms, covenants and conditions of
agreements, easements and restrictions of record applicable to the Property, all of which Tenant
shall perform and observe insofar as the same are applicable to the Premises; provided, however,
that Tenant shall not be bound by any easements or restrictions made after the date of this Lease
that materially and adversely affect Tenant’s rights and obligations under this Lease unless and
until Landlord has obtained Tenant’s prior written consent. Landlord hereby represents and
warrants that none of the existing agreements, easements and restrictions of record prohibit or
restrict use of the Premises for the Permitted Uses.

     The Premises exclude common areas and facilities of the Building, including without limitation
exterior walls, roofs, the common stairways and stairwells, the parking garage, elevators and
elevator wells, fan rooms, electric and telephone closets (other

- 1 -

 

than those exclusively serving the Premises, if any), janitor closets, freight elevators, and
pipes, ducts, conduits, wires and appurtenant fixtures serving other parts of the Property
(exclusively or in common) and other common areas and facilities from time to time designated as
such by Landlord; provided that, in any event, the designation of such common areas and facilities
does not adversely affect the Premises, Tenant’s use of the Premises, or access to the Premises in
more than a de minimis manner. If the Premises include less than the entire rentable area of any
floor, then the Premises also exclude the common corridors, common elevator lobby and common
toilets located on such floor.

     Section 1.02. Special Appurtenant Rights.

               (a) Tenant shall, subject to reasonable closures for repairs and the like, casualty, and
condemnation, have the appurtenant, non-exclusive right, in common with others, to use the common
fitness center (subject only to nominal charges for use of basic services) and cafeteria (with
associated patio area) located at the Building, in each case subject to reasonable rules
established by Landlord from time to time pursuant to Section 5.04 of this Lease, and which
services shall, subject to the matters set forth above, be available throughout the term of this
Lease (the facilities referred to in this paragraph, collectively, the “Amenities”).

     Landlord and Tenant acknowledge that Landlord intends to retain a third-party vendor for the
operation of the cafeteria in the Building. If the service provided by any third-party vendor
operating the cafeteria from time to time is inconsistent with first-class standards for a suburban
office, laboratory and research and development park in more than a de minimus manner, Tenant shall
have the right to give Landlord written notice of such event with sufficient detail for Landlord to
investigate the complaint. At the written request of Tenant, Landlord shall exercise its right to
terminate the contract of such vendor, in which event Landlord shall use reasonable efforts to
replace the applicable vendor with a substitute vendor experienced in operating similar facilities
in first class suburban office, laboratory and research and development buildings, subject to
Tenant’s rights under the immediately preceding paragraph. Landlord shall consult with Tenant in
the process of making menu selections for the cafeteria.

               (b) So long as Landlord or an entity controlled by, under common control with, or controlling
Landlord is the owner of the property known as 840 Winter Street, Waltham, Massachusetts (also
known as “Healthpoint”), Tenant shall be entitled to the benefit of any discounted rates
for the fitness facilities located at Healthpoint, if any, that are negotiated between Landlord and
the owner of Healthpoint for the benefit of tenants at the Building.

               (c) Tenant shall have the appurtenant, non-exclusive right, in common with others, to
reasonably access any Building communication system serving the Premises (which access shall be
reasonably coordinated and facilitated by Landlord) and the exclusive right and obligation to use
and maintain the heating, ventilation and air-conditioning units installed on the roof and
exclusively serving the second and third floors of the Premises, together with the rights to use
the roof further described in Article 21, below.

- 2 -

 

               (d) Landlord shall cooperate with Tenant during Tenant’s design of the Finish Work to identify
an appropriate portion or portions of the parking garage beneath the Building in which Tenant may
install a pH neutralization system and other lab equipment and systems serving the Premises (such
areas collectively being referred to as the “PH Rooms”). In no event shall the PH Rooms
exceed 750 square feet in gross floor area in the aggregate. Landlord and Tenant shall enter into
a written instrument identifying the location of the PH Rooms upon determining their location, in
which event such areas shall be deemed to be appurtenant to the Premises and available for Tenant’s
exclusive use. If the location of the PH Rooms, as agreed to by Landlord, results in the loss of
one or more parking spaces serving the Building, then such eliminated parking space(s) shall be
counted towards Tenant’s parking allocation under Section 20.10 of this Lease.

               (e) Tenant shall, subject to reasonable closures for maintenance and repairs (for which
Landlord shall provide Tenant with reasonable prior notice where feasible), casualty, and
condemnation, have the appurtenant, exclusive right to use the two (2) elevators identified as
“Tenant Exclusive Elevators” on Exhibit 1.01-1 for access and egress to the
Premises. Notwithstanding the foregoing, except for casualty or condemnation and subject to the
provisions of Section 3.02, at least one of the Tenant Exclusive Elevators shall be available 24
hours per day, 365 days per year during the Term.

     Section 1.03. Term Commencement. Tenant and Landlord acknowledge and agree that the
Premises shall be delivered by Landlord in two phases: the first and third floor of the Premises
and associated basement areas (the “Office Portion”) shall be delivered first, and the
second floor of the Premises and associated basement areas shall be delivered second (the “Lab
Portion”; either the Office Portion or the Lab Portion being referred to herein as a
“Portion”).

               (a) The term of this Lease for each Portion of the Premises shall commence on the earlier of
(i) the Delivery Date (as defined below), or (ii) the date Tenant enters into possession of all or
any substantial portion of such Portion for the conduct of its business (for the purposes of this
Section 1.03, “conduct of its business” shall not include installation of furniture, fixtures,
equipment, or the like). The date of commencement for each Portion as so determined is hereinafter
referred to as the “Commencement Date.” The term shall expire at 11:59 p.m. on the date
(the “Expiration Date”) that is the last day of the calendar month in which the 10th
anniversary of the initial Rent Commencement Date (as defined in Section 2.01) occurs, unless
extended or sooner terminated as hereinafter provided and shall include the period between the
Commencement Date and the initial Rent Commencement Date. Landlord will provide Tenant with at
least fourteen (14) days prior notice of each Delivery Date. If the Delivery Date designated in
such notice does not occur on the initially designated date, Landlord shall keep Tenant informed of
the anticipated Delivery Date and shall be required to give Tenant at least two (2) business days
prior notice of the applicable Delivery Date as so extended.

     The “Delivery Date” shall mean the date on which Landlord Substantially Completes the
Landlord Work (as defined in Exhibit 7.02) for a Portion of the Premises and delivers such
Portion to Tenant. The “Estimated Delivery Date” means December 1, 2009, with respect to
the Office Portion and February 1, 2010, with respect to the Lab Portion, as such dates are
extended for Tenant Delay

- 3 -

 

and matters described in Section 20.14. Landlord’s failure to Substantially Complete the
Finish Work and deliver the Premises on or before the applicable Estimated Delivery Date, for any
reason, shall not give rise to any liability of Landlord hereunder, shall not constitute a
Landlord’s default, shall not affect the validity of this Lease, and shall have no effect on the
beginning or end of the term of this Lease as otherwise determined hereunder or on Tenant’s
obligations associated therewith except that:

          (i) if the Commencement Date for the Office Portion occurs more than 30 days after the
Estimated Delivery Date for the Office Portion as it may be extended, then, as liquidated damages
Tenant shall receive an abatement of Base Rent allocable to the Office Portion equal to (x) one day
for each day following such 30-day period through the 60th day following the Estimated Delivery
Date with respect to the Office Portion, and (y) two days for each day thereafter until the
Commencement Date for the Office Portion occurs.

          (ii) if the Commencement Date for the Lab Portion occurs more than 60 days after the Estimated
Delivery Date for the Lab Portion as it may be extended, then, as liquidated damages Tenant shall
receive an abatement of Base Rent allocable to the Lab Portion equal to (i) one day for each day
following such sixty-day period through the 90th day following the Estimated Delivery Date with
respect to the Lab Portion, and (ii) two days for each day thereafter until the Commencement Date
for the Lab Portion occurs; and

          (iii) Notwithstanding the foregoing, in the event that the Commencement Date for the Office
Portion fails to occur within 135 days after the Estimated Delivery Date for the Office Portion,
then Tenant shall have the one-time option to elect either to (A) terminate this Lease or (B)
complete all of the Landlord Work at its sole cost and expense (except as set forth below) and in
compliance with Article 8 hereof, in either case upon thirty (30) days prior written notice to
Landlord; provided, however, that if the Commencement Date for the Office Portion occurs within
such thirty (30) day period, then such election shall be of no force or effect. Notwithstanding
anything to the contrary herein, if Tenant makes the election set forth in clause (B), above, then
Tenant may apply any unused Finish Work Allowance towards any work undertaken pursuant to clause
(B) pursuant to (and subject to the provisions of) Exhibit 7.02 and shall, to the extent
not reimbursed through use of the Finish Work Allowance, have the right to reimbursement by
Landlord (on 30 days prior notice) for Tenant’s reasonable third party costs and expenses to
complete such Landlord Work to the extent exceeding the amount of Excess Finish Work costs that
Tenant would otherwise have incurred in the completion of such Landlord Work by Landlord; and

          (iv) Notwithstanding the foregoing, in the event that the Commencement Date for the Lab
Portion fails to occur within 135 days after the Estimated Delivery Date for the Lab Portion, then
Tenant shall have the one time option to elect either to (A) terminate this Lease solely with
respect to the Lab Portion of the Premises, or (B) complete the Landlord Work for the Lab Portion
at its sole cost and expense (except as set forth below) and in compliance with Article 8 hereof,
in either case upon thirty (30) days prior written notice to Landlord; provided, however, that if
the Commencement Date for the Lab Portion occurs within such thirty (30) day

- 4 -

 

period, then such election shall be of no force or effect. In the event that Tenant makes the
election set forth in (A), above, then the Lab Portion (which the parties agree consists of 33,443
rentable square feet) shall be deemed to be removed from the Premises and the Base Rent, Tenant’s
Pro Rata Share, Finish Work Allowance and any other rights under this Lease that are expressly
derived on a per-square-foot basis shall be adjusted accordingly. Notwithstanding anything to the
contrary herein, if Tenant makes the election set forth in clause (B), above, then Tenant may apply
any unused Finish Work Allowance towards any work undertaken pursuant to clause (B) to the extent
elected by Tenant pursuant to (and subject to the provisions of) Exhibit 7.02 and shall, to
the extent not reimbursed through use of the Finish Work Allowance, have the right to reimbursement
by Landlord (on 30 days prior notice) for Tenant’s reasonable third party costs and expenses to
complete such Landlord Work to the extent exceeding the amount of Excess Finish Work costs that
Tenant would otherwise have incurred in the completion of such Landlord Work by Landlord.

          (v) In connection with the exercise of this Lease, Landlord has provided Tenant with a
guaranty from The Prudential Insurance Company of America, acting solely on behalf of or for the
benefit of its insurance company separate account PRISA II, in the form attached as Exhibit 1.03.

     The remedies set forth in this Section 1.03(a) are Tenant’s sole and exclusive remedies, at
law or in equity, with respect to Landlord’s timely delivery of the Premises and timely Substantial
Completion of the Landlord Work.

               (b) Tenant and Landlord agree to execute an agreement in recordable form identifying the
actual Commencement Dates, the Rent Commencement Dates, and the Expiration Date, but a failure to
execute such an agreement shall not affect the commencement or expiration of the term of this
Lease.

     THIS LEASE IS MADE UPON THE COVENANTS, AGREEMENTS, TERMS, PROVISIONS, CONDITIONS AND
LIMITATIONS SET FORTH HEREIN, ALL OF WHICH TENANT AND LANDLORD EACH COVENANT AND AGREE TO PERFORM
AND COMPLY WITH, EXCEPTING ONLY AS TO THE COVENANTS OF THE OTHER:

Article 2.

Rent

     Section 2.01. Base Rent. (a) The “Rent Commencement Date” shall mean,
respectively, (x) the date that is six months after the Commencement Date for the Office Portion
and (y) the date that is five months month after the Commencement Date for the Lab Portion.
Beginning on the Rent Commencement Date for the applicable Portion, and on the first day of each
month thereafter, the Tenant shall pay the Landlord base rent (“Base Rent”) in equal
monthly installments, in advance, pursuant to the following schedule:

- 5 -

 

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Annual Base Rent	 	Annual Base Rent	 	Monthly Base Rent
	 	 	for the entire	 	Per Rentable Square	 	for the entire
	Period	 	Premises*	 	Foot	 	Premises*
	From the Rent
Commencement Date
through the last
day of the 42nd
calendar month
	 	$	2,505,875.00	 	 	$	25.00	 	 	$	208,822.92	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	From the first day
of the 43rd
calendar month
through the last
day of the 78th
calendar month
	 	$	2,706,345.00	 	 	$	27.00	 	 	$	225,528.75	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	From the first day
of the 79th
calendar month
through the
expiration of the
term of this Lease
	 	$	2,936,885.50	 	 	$	29.30	 	 	$	244,740.46	 

 

			
	*	 	In the event that the Office Portion and Lab Portion Rent Commencement Dates do not occur on
the same day, the Annual Base Rent and Monthly Base Rent shall be apportioned accordingly (e.g.
66.6% of the Annual Base Rent is allocable to the Office Portion and 33.4% is allocable to the Lab
Portion).

     If any Rent Commencement Date is other than the first day of the month, then, with respect to
the partial month following such Rent Commencement Date, Tenant shall pay to Landlord on the
applicable Rent Commencement Date a pro-rated share of the Base Rent that would have otherwise been
payable for such month (based on the number of days remaining in such month) had such Rent
Commencement Date occurred on the first day of such month.

     Section 2.02. Additional Rent for Operating Expenses and Taxes.

- 6 -

 

               (a) Commencing on the Commencement Date for each Portion of the Premises, Tenant shall pay as
Additional Rent to Landlord Tenant’s Pro Rata Share of Taxes (as defined below) and Tenant’s Pro
Rata Share of all Operating Expenses (as defined below). If at any time within any calendar year,
less than 95% of the rentable space of the Building or Property is leased and occupied under
agreements for which the lease term has commenced, Operating Expenses that vary with such occupancy
for that calendar year during the term of this Lease shall be computed and adjusted upward so that
Operating Expenses shall at all times equal the greater of (i) actual Operating Expenses or (ii) an
amount extrapolated as if the Building or Property, as applicable, were ninety-five (95%) leased.

     Additional Rent computed under this Section 2.02 shall be prorated should this Lease commence
or terminate before: (i) the end of any fiscal tax year for that portion related to Taxes; or (ii)
the end of any calendar year for that portion related to Operating Expenses. Tenant shall make
monthly payments of Additional Rent, in advance, on the applicable Commencement Date and the first
of each month thereafter equal to one-twelfth (1/12) of the annual amount of such Additional Rent
reasonably projected by Landlord to be due from Tenant (pro-rated for any partial month at the
beginning or end of the term) from time to time. Tenant’s monthly payments may be reasonably
revised by Landlord from time to time so that Tenant’s aggregate monthly payments shall equal the
Additional Rent then projected to be due for the year in question. A final accounting and payment
for each real estate tax and operating period shall be made within thirty (30) days after written
notice from Landlord of the exact amount of such Additional Rent for the fiscal tax year or
calendar year in question (each, a “Reconciliation Notice ”), which notice Landlord shall
endeavor to deliver to Tenant within ninety (90) days after the end of each fiscal tax year or
calendar year, as applicable, and, in any event, Landlord shall deliver within 270 days after the
end of each fiscal tax year or calendar year, as applicable. Landlord’s statements of Additional
Rent for Operating Expenses and Taxes shall be conclusive and binding on Tenant unless disputed
within six months after the respective year-end statements are issued. In the event that the
Additional Rent due with respect such period is finally determined to be less than the Additional
Rent paid by Tenant on account of Landlord’s projection of Additional Rent, Landlord shall credit
the difference against the next installment of Rent coming due under this Lease or, if no such
installment is coming due, then Landlord shall promptly refund such difference. In the event Taxes
for the Premises, based upon which Tenant shall have paid Additional Rent, are subsequently reduced
or abated, Tenant shall be entitled to receive its allocable share of the amount abated, provided
that the amount of the rebate allocable to Tenant shall in no event exceed the amount of Additional
Rent paid by Tenant for such fiscal year on account of Taxes under this Section 2.02, and further
provided the rebate allocable to Tenant shall be reduced by its allocable share of the reasonable
cost of obtaining such reduction or abatement not otherwise paid by Tenant. The obligations of
this paragraph shall survive the expiration of the Lease.

     “Tenant’s Pro Rata Share” is calculated by dividing the rentable square foot area of
the Premises by the rentable square foot area of the Building, as of the date of the computation.
Tenant’s Pro Rata Share is initially 37.1% for the Office Portion and 55.7% for the entire Premises
and is subject to adjustment if the rentable square footages of the Premises changes on account of
any

- 7 -

 

amendment to the Lease or the Building changes on account of any remeasurement, reconstruction
or expansion by Landlord. The Building consists of 180,039 rentable square feet, subject to
adjustment pursuant to the immediately preceding sentence.

               (b) “Operating Expenses” for the purpose of this Section shall mean:

                    (1) All expenses incurred by the Landlord or its agents which shall be directly related to
employment of day and night supervisors, janitors, handymen, engineers, mechanics, electricians,
plumbers, porters, cleaners, accounting and management personnel, and other personnel (including
amounts incurred for wages, salaries and other compensation for services, payroll, social security,
unemployment and similar taxes, workmen’s compensation, insurance, disability benefits, pensions,
hospitalization, retirement plans and group insurance, uniforms and working clothes and the
cleaning thereof, and expenses imposed on the Landlord or its agents pursuant to any collective
bargaining agreement), for services in connection with the operation, management, repair,
maintenance, cleaning and protection of the Property and appurtenant common areas and facilities
serving the Premises in a manner customarily provided to first class suburban mixed use office,
laboratory and research and development parks in the suburban Boston area including without
limitation repair and maintenance and providing the services required by this Lease, and, subject
to clause (c)(1) below, personnel engaged in supervision of any of the persons mentioned above
(collectively the “Operation of the Property”);

                    (2) The cost of services, materials and supplies furnished or used in the Operation of the
Property;

                    (3) The cost of replacements for tools and equipment used in the Operation of the Property;

                    (4) Commercially reasonable management fees paid to managing agents and for reasonable legal
and other professional fees relating to the Operation of the Property, but excluding legal and
other professional fees paid in connection with negotiation, administration or enforcement of
leases; provided, however, that so long as an affiliate of the Landlord manages the Property,
management fees for the Property shall not exceed the greater of $75,000 or three percent (3%) of
the gross income from tenants of the Property (including Base Rent and all Additional Rent)
computed on an annual basis plus reimbursements;

                    (5) Insurance premiums in connection with the Operation of the Property, including without
limitation for such insurance coverages and amounts as Landlord or its mortgagees may require from
time to time;

                    (6) The costs of plowing and snow removal, maintaining landscaping and storm water drainage
systems, maintaining parking garages, other parking areas, driveways, roadways, light poles, entry
areas, and loading docks in good repair reasonably free of snow and ice (costs for shared
facilities shall be allocated as set forth in clause 8 below), and the cost to provide the shuttle
services described in Exhibit 3.02;

- 8 -

 

                    (7) Amounts paid to independent contractors for services, materials and supplies furnished for
the Operation of the Property;

                    (8) Condominium assessments and charges;

                    (9) All other expenses incurred in connection with the Operation of the Property, including
expenditures for maintenance and repairs that are classified as capital expenditures in accordance
with generally accepted accounting principles, consistently applied, and for capital improvements
and replacements that (A) will, in Landlord’s reasonable estimate, result in a reduction in
Operating Expenses payable by Tenant (but only to the extent of such reduction) or (B) are required
by changes in law occurring after the first Delivery Date to occur or enforcement of laws not
generally occurring on such Delivery Date) to the extent not otherwise excluded as Operating
Expenses, phone charges, travel (to the extent related to the performance of services included in
Operating Expenses), costs of customary waste and recyclables removal, security and life safety
systems testing, common area electricity and cleaning, and utilities, any expenses in the nature of
common area charges for operation, maintenance and repair of driveways, parking garages, if any,
and other facilities or services shared with other buildings or premises, and any condominium
common expenses assessed against a condominium unit comprising the Premises. Any capital
expenditures included in Operating Expenses pursuant to this paragraph shall be amortized on a
straight line basis over the useful life of the item in question, as determined by Landlord using
generally accepted accounting principles, consistently applied, together with interest at
Landlord’s actual interest rate incurred in financing such capital improvements, or, if no part of
such expenditure is financed, at an imputed interest rate equal to the prime rate of interest as
reported by Bank of America, N.A., plus three (3%) percent; and

                    (10) Costs incurred in connection with the operation of the common fitness room and cafeteria,
except to the extent covered by fees for use of such facilities.

               (c) Operating Expenses shall be computed on an accrual basis and shall be determined in
accordance with generally accepted accounting principles consistently applied. They must be
actually incurred, but may be incurred directly or by way of reimbursement, and shall include taxes
applicable thereto. The following shall be excluded from Operating Expenses:

                    (1) Salaries and related benefits or any portion thereof for officers and executives of the
Landlord or Landlord’s managing agent above the level of property manager.

                    (2) Depreciation of the Premises or any improvements thereon.

                    (3) Interest and amortization on indebtedness (except as expressly provided above).

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                    (4) Expenses for which the Landlord, by the terms of this Lease or otherwise, makes a separate
charge.

                    (5) The cost of any electric current or other utilities or services paid for by the Tenant or
by other tenants as a separate charge.

                    (6) Leasing fees or commissions.

                    (7) Repairs or other work occasioned by the exercise of right of eminent domain.

                    (8) Renovating or otherwise improving or decorating, painting or redecorating space for
tenants or other occupants or vacant tenant space, other than maintenance and repairs required by
this Lease and work in common areas.

                    (9) Landlord’s costs of utilities and other services sold separately to tenants for which
Landlord is entitled to be reimbursed by such tenants as a separate charge over and not as part of
the base rent, operating expense, or other rental amounts payable under the lease with such tenant.

                    (10) Expenses in connection with services or other benefits of a type which Tenant is not
entitled to receive under the Lease but which are provided to another tenant or occupant.

                    (11) Expenses, including rental, created under any ground or underlying leases.

                    (12) Any particular items and services for which a tenant otherwise reimburses Landlord by
direct payment over and above the base rent, operating expenses and other rental amounts payable
under the applicable lease.

                    (13) Any expense for which Landlord is compensated through proceeds of insurance, condemnation
or otherwise.

                    (14) Expenses for periods of time not included within the term of this Lease.

                    (15) Expenses that are considered capital improvements and replacements under generally
accepted accounting principles, except to the extent expressly permitted pursuant to clause (b)(9),
above.

                    (16) Cost of rebuilding after casualty or taking, other than insurance deductibles.

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                    (17) All Operating Expenses shall be reduced by the amount (net of collection costs) of any
insurance reimbursement, discount or allowance received by the Landlord in connection with such
costs.

                    (18) Costs incurred in the acquisition and development of the Property including the
correction of any defective Base Building Work.

                    (19) Environmental testing, and the cost of complying with applicable federal, state and local
laws, regulations and rules dealing with handling, storage and disposal of Hazardous Materials
(other than those ordinarily found or used in the customary operation of first class office
buildings), including clean up costs, and any related matters, except in each case to the extent
caused by Tenant or any party for whom Tenant is legally responsible.

                    (20) That portion of employee expenses allocable to work that is not for the benefit of the
Property or common areas and facilities serving the same; if employees work at more than one
location, their compensation and other labor costs shall be properly allocated.

                    (21) Administrative fees and compensation for Landlord’s and managing agent’s general
administrative staff, to the extent not directly attributable to the management, operation,
maintenance and repair of the Property or common areas and facilities serving the Property (other
than the management fee referred to in subsection (b)(4), above).

                    (22) Franchise or income taxes imposed on Landlord.

                    (23) Costs incurred by Landlord as a result of any violation by Landlord or any other tenant
of the terms and conditions of any lease of space.

                    (24) Costs related to maintaining Landlord’s existence, either as a corporation, partnership,
or other entity, or costs incurred by Landlord relative to any debt that encumbers the Property (by
example these costs shall include, but not be limited to income tax return preparation, filing
costs, legal costs, etc.).

                    (25) Costs arising from Landlord’s charitable contributions not to exceed $500 per year (such
amount to be increased, but never decreased, annually in proportion to any increase in the Consumer
Price Index — All Urban Consumers for the Boston Metropolitan area published by the U.S. Department
of Labor or a comparable index reasonably selected by Landlord (such index being referred to herein
as the “CPI”)).

                    (26) Costs for reserves of any kind.

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                    (27) Costs incurred in connection with Building events for tenants, including, but not limited
to, tenant parties, holiday gifts and tenant welcoming gifts.

                    (28) Costs for any services to the Premises that are assumed by Tenant pursuant to Section
3.03 of this Lease, whether provided to Tenant or to other tenants of the Building in their
premises.

                    (29) Costs of audited financial statements, but only to the extent the same is in excess of
$15,000 in any single lease year (such amount to be increased, but never decreased, annually in
proportion to any increase in the CPI).

               (d) “Taxes” means all taxes, assessments, betterments, excises, user fees imposed by
governmental authorities, and all other governmental charges and fees of any kind or nature, or
impositions or agreed payments in lieu thereof or voluntary payments made in connection with the
provision of governmental services or improvements of benefit to the Building or the Property),
assessed or imposed against the Building or the Property (including without limitation any personal
property taxes levied on such property or on fixtures or equipment used in connection therewith),
other than a federal or state income tax of general application. Notwithstanding anything to the
contrary herein, Taxes shall exclude (a) any land acquisition costs, and any other fee, cost or tax
(other than increases in real property taxes resulting from reassessments of the Property)
associated with the development or construction of the Property and (b) any interest or penalties
for late payments to the extent relating to a period in which Tenant was not in default of its
obligations to pay Tenant’s Pro Rata Share of Taxes, and (c) any income, capital levy, transfer,
capital stock, gift, estate or inheritance tax. The amount of any special taxes, special
assessments and agreed or governmentally imposed “in lieu of tax” or similar charges shall be
included in Taxes for any year but shall be limited to the amount of the installment (plus any
interest, other than penalty interest, payable thereon) of such special tax, special assessment or
such charge required to be paid during or with respect to the year in question. Betterments and
assessments, whether or not paid in installments, shall be included in Taxes in any tax year as if
the betterment or assessment were paid in installments over the longest period permitted by law,
together with the interest thereon charged by the assessing authority for the payment of such
betterment or assessment in installments.

     If during the term of this Lease the present system of ad valorem taxation of property shall
be changed so that, in lieu of or in addition to the whole or any part of such ad valorem tax there
shall be assessed, levied or imposed on such property or on Landlord any kind or nature of federal,
state, county, municipal or other governmental capital levy, income, sales, franchise, excise or
similar tax, assessment, levy, charge or fee (as distinct from the federal and state income tax in
effect on the date of this Lease) measured by or based in whole or in part upon building valuation,
mortgage valuation, rents, services or any other incidents, benefits or measures of real property
or real property operations, then any and all of such taxes, assessments, levies, charges and fees
shall be included within the term of Taxes, but only to the extent that the same would be payable
if the Property were the only property of Landlord. Taxes shall also include expenses, including
reasonable fees of attorneys, appraisers and other consultants, incurred in connection with any
efforts to obtain abatements or reduction or to assure maintenance of Taxes for any year wholly or
partially included in the term of this

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Lease, whether or not successful and whether or not such efforts involved filing of actual
abatement applications or initiation of formal proceedings.

               (e) Tenant shall have the right for a period of ninety (90) days (the “Audit Period”)
following its receipt of Landlord’s statement of Additional Rent due on account of Operating
Expenses to examine and copy Landlord’s books and records concerning Operating Expenses for the
calendar year covered by such statement in the offices of the property manager or another location
reasonably designated by Landlord in the greater Boston area, so long as Tenant pays any amount
billed by Landlord on account of Additional Rent without protest (but subject to Tenant’s right to
recover any overpayments pursuant to this paragraph). Tenant’s audit may be conducted by its
employees or its designated accountants, provided that the accountants must be employed on a
regular fee for services basis and not on a contingency fee basis. If, by notice to Landlord given
after such examination but during the Audit Period (which notice shall be accompanied by
documentation evidencing the results of Tenant’s audit to Landlord’s reasonable satisfaction),
Tenant disputes the amount of Additional Rent for Operating Expenses shown on the statement, then
Tenant may request that the amount of Additional Rent for Operating Expenses for the year in
question be determined by an audit conducted by a certified public accountant reasonably selected
by both parties, provided that if the parties are unable so to agree on an accountant within ten
(10) days after receipt of Tenant’s notice, then within twenty (20) days after Tenant’s notice is
given Tenant may submit the dispute for determination by an arbitration conducted by a single
arbitrator in the Boston Office of the American Arbitration Association (“AAA”) in
accordance with the AAA’s Commercial Arbitration Rules. The arbitrator shall be selected by the
AAA and shall be a certified public accountant with at least ten (10) years of experience in
auditing mixed use office, laboratory and research and development buildings in the suburban Boston
area. The cost of the accountant selected by both parties, and the arbitrator, if applicable,
shall be shared equally by the parties. Tenant and each person reviewing Landlord’s books and
records or participating in the arbitration shall agree in an instrument prepared by Landlord that
all information obtained from Landlord’s books and records shall be kept confidential and used only
for the purpose of determining amounts properly due under this Lease. If the Additional Rent due
is finally determined to be less than the Additional Rent paid by Tenant on account of Landlord’s
calculation of Operating Expenses, Landlord shall either promptly refund to Tenant the difference
or credit same against Rent next due from Tenant. If the Additional Rent due was less than
ninety-five percent (95%) of the Additional Rent paid by Tenant on account of Landlord’s
calculation of Operating Expenses, Landlord shall reimburse Tenant for the reasonable third-party
costs of reviewing Landlord’s books and records, but in any event not to exceed $4,000 (such amount
to be increased, but never decreased, annually in proportion to any increase in the CPI).

               (f) Operating Expenses which are incurred jointly for the benefit of the Building and another
building or premises shall be allocated between the Building and the other building or premises in
accordance with the ratio of their respective rentable areas calculated using a consistent
methodology, unless Landlord reasonably determines that the other building or premises is used for
a purpose materially different than the Building or that the Operating Expense in question results
from a service provided or used in a materially disproportionate manner, in which case the affected
cost items shall be allocated on a reasonable basis by

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Landlord. Landlord may elect to allocate Operating Expenses separately among tenants with
different use categories in the Building from time to time based on such factors as the Landlord
reasonably determines (rather than on a proportionate basis based on square feet) if Landlord
reasonably determines it is necessary to fairly allocate the Operating Expenses. If the Building
and the land appurtenant thereto are not assessed as a separate tax parcel, then real estate taxes
shall be allocated between the Building and the balance of the tax parcel based on the factors
taken into account by the municipal tax assessor or such other reasonable method as Landlord may
elect, which may be based on the relative square footages of the buildings and their use or may be
in accordance with the ratio of their respective fair market values. In the event of a dispute
concerning the allocation of Operating Expenses or Taxes, then the matter shall be submitted by
Landlord and Tenant for resolution by arbitration in accordance with the procedures set forth in
Section 2.02(e).

     Section 2.03. Payment of Rent. The term “Additional Rent” shall mean all
amounts due under Section 2.02 for Operating Expenses and Taxes, and all other amounts (except Base
Rent) to be paid by Tenant to Landlord in accordance with the terms of this Lease, including
without limitation payments to Landlord for reimbursement of any costs expended upon an Event of
Default by Tenant. The term “Rent” shall mean Base Rent and Additional Rent. All payments
of Rent shall be made without set-off, deduction or offset except as expressly provided in this
Lease. All payments of Rent shall be made to the Landlord at c/o  Davis Marcus Management, One
Appleton Street, Boston, Massachusetts 02116, Attn: Larry Lenrow, or as may be otherwise directed
by the Landlord in writing, which may include a direction to pay by wire transfer to an account
specified by Landlord. Without limiting the foregoing, Tenant’s obligation to pay Rent shall be
absolute, unconditional, and independent and shall not be discharged or otherwise affected by any
law or regulation now or hereafter applicable to the Premises, or any other restriction on Tenant’s
use, or, except as provided in Article 11, any casualty or taking, or any failure by Landlord to
perform or other occurrence; and, except as expressly provided in this Lease, Tenant assumes the
risk of the foregoing and waives all rights now or hereafter existing to quit or surrender the
Premises or any part thereof, to terminate or cancel this Lease, or to assert any defense in the
nature of constructive eviction to any action seeking to recover rent. Subject to the provisions
of this Lease, however, Tenant shall have the right to injunctive relief or to seek judgments for
direct money damages occasioned by Landlord’s breach of its Lease covenants.

     Section 2.04. Rent from Real Property. It is intended that all Rent payable by Tenant
to Landlord, which includes all sums, charges, or amounts of whatever nature to be paid by Tenant
to Landlord in accordance with the provisions of this Lease, shall qualify as “rents from real
property” within the meaning of both Sections 512(b)(3) and 856(d) of the Internal Revenue Code of
1986, as amended (the “Code”) and the U.S. Department of Treasury Regulations promulgated
thereunder (the “Regulations”). If Landlord, in its sole discretion, determines that there
is any risk that all or part of any Rent shall not qualify as “rents from real property” for the
purposes of Sections 512(b)(3) or 856(d) of the Code and the Regulations, Tenant agrees (i) to
cooperate with Landlord by entering into such amendment or amendments to this Lease as Landlord
reasonably deems necessary to qualify all Rent as “rents from real property,” and (ii) to permit an
assignment of this Lease; provided, however, that any adjustments required under this section shall
be made so as to produce the equivalent (in economic terms) Rent as payable before the adjustment.

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     Section 2.05. Security Deposit. On or before April 27, 2009, Tenant shall deliver to
Landlord as security for the performance of the obligations of Tenant hereunder a letter of credit
in the initial amount of $1,000,000 (the “Letter of Credit Amount”) in accordance with this
Section 2.05 (as renewed, replaced, increased and/or reduced pursuant to this Section 2.05, the
“Letter of Credit”). Tenant’s failure to timely deliver the Letter of Credit to Landlord,
or increase the amount of the Letter of Credit as required under this Section 2.05, at any time
pursuant to this Section 2.05 shall constitute an Event of Default under this Lease, without any
notice or cure period under Article 14. The Letter of Credit (i) shall be irrevocable and shall be
issued by a commercial bank reasonably acceptable to Landlord that has an office for presentment in
the City of Waltham or City of Boston, in the form attached as Exhibit 2.05 or such other
substantially similar form as is reasonably acceptable to Landlord, (ii) shall require only the
presentation to the issuer of a certificate of the holder of the Letter of Credit stating that
Landlord is entitled to draw on the Letter of Credit pursuant to the terms of this Lease,
(iii) shall be payable to Landlord or its successors in interest as the Landlord and shall be
freely transferable without cost to Landlord, any such successor or any lender holding a collateral
assignment of Landlord’s interest in the Lease, (iv) shall be for an initial term of not less than
one year and contain a provision that such term shall be automatically renewed for successive
one-year periods unless the issuer shall, at least 45 days prior to the scheduled expiration date,
give Landlord notice of such non-renewal, and (v) shall otherwise be in form and substance
reasonably acceptable to Landlord. Landlord acknowledges that, as of the date of this Lease, Bank
of America is an approved issuer of the Letter of Credit. Notwithstanding the foregoing, the term
of the Letter of Credit for the final period shall be for a term ending not earlier than the date
sixty (60) days after the last day of the Term. Tenant acknowledges that Landlord may be required
to pledge the proceeds of the Letter of Credit to any lender holding a collateral assignment of
Landlord’s interest in the Lease and agrees to provide Landlord with such documentation as Landlord
may reasonably request, and to cooperate with Landlord as is necessary, to evidence the consent to
such pledge by the issuer of the Letter of Credit.

               (a) The Letter of Credit Amount shall be increased by Tenant (via amendment to the
then-existing Letter of Credit or by supplying Landlord with a replacement Letter of Credit) by the
amount of $1,500,000 if Tenant fails, at any time during the term of this Lease, to meet the
Financial Test (as hereinafter defined). The “Financial Test” shall mean that Tenant has
unrestricted cash and cash equivalents, as determined in accordance with generally accepted
accounting principles, consistently applied, equal to at least $50,000,000 in United States
dollars. If, at any time after the Letter of Credit is increased pursuant to the foregoing, Tenant
subsequently meets the Financial Test for three complete calendar quarters in a row and reasonably
evidences the same to Landlord, then, provided that Tenant is not then in default beyond applicable
notice or cure periods and no Bankruptcy Event (as defined below) is then in effect, Tenant shall
be entitled to reduce the Letter of Credit by the amount of $1,500,000 (but to an amount equal to
no less than $1,000,000) until such time, if any, that Tenant subsequently fails to meet the
Financial Test. A “Bankruptcy Event” shall mean that Tenant files a voluntary petition in
bankruptcy or shall be adjudicated a bankrupt or insolvent, shall file any petition or answer
seeking any reorganization, arrangement, composition, dissolution or similar relief under any
present or future federal, state or other statute, law or regulation relating to bankruptcy,
insolvency or other relief for debtors, or shall seek, or consent, or acquiesce in the appointment
of any trustee, receiver or liquidator of Tenant of all or any substantial part of their respective

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properties, or of the Premises, or shall make any general assignment for the benefit of
creditors; or any court enters an order, judgment or decree approving a petition filed against
Tenant seeking any reorganization, arrangement, composition, dissolution or similar relief under
any present or future federal, state or other statute, law or regulation relating to bankruptcy,
insolvency or other relief for debtors.

     Landlord shall be entitled to draw upon the Letter of Credit in part or for its full amount,
as Landlord may elect (i) if an Event of Default is then continuing (or if Tenant has failed to
timely pay rent or perform any of its other obligations under the Lease and transmittal of a
default notice or running of any cure period is barred or tolled by applicable law), (ii) if, not
less than 30 days before the scheduled expiration of the Letter of Credit, Tenant has not delivered
to Landlord a new Letter of Credit in accordance with this Section 2.05 (which failure shall be
deemed a default without notice or cure period) or (iii) if the credit rating of the long-term debt
of the issuer of the Letter of Credit (according to Moody’s or similar national rating agency) is
downgraded to a grade below investment rate), or if the issuer of the Letter of Credit shall enter
into any supervisory agreement with any governmental authority, or if the issuer of the Letter of
Credit shall fail to meet any capital requirements imposed by applicable law. Landlord may, but
shall not be obligated to, apply the amount so drawn to the extent necessary to cure an Event of
Default under the Lease and/or make any payments due to Landlord hereunder on account of such Event
of Default including without limitation any unpaid Rent, any damages arising from a termination of
this Lease in accordance with its terms, and for any damages arising from any rejection of this
Lease in a bankruptcy proceeding commenced by or against Tenant. Any amount drawn in excess of the
amount applied by Landlord pursuant to the immediately preceding sentence shall be held by Landlord
as a security deposit for the performance by Tenant of its obligations hereunder. Said security
deposit may be mingled with other funds of Landlord, and no fiduciary relationship shall be created
with respect to such deposit, nor shall Landlord be liable to pay Tenant interest thereon. If
Tenant shall fail to perform any of its obligations under this Lease, Landlord may, but shall not
be obliged to, apply the security deposit to the extent necessary to cure the Event of Default
and/or make any payments due to Landlord hereunder on account of such Event of Default. After any
such application by Landlord of the Letter of Credit or security deposit, Tenant shall reinstate
the Letter of Credit to the amount then required to be maintained hereunder, upon demand (and, upon
such reinstatement, Landlord shall return any cash security deposit then being held by Landlord to
Tenant). Within forty-five (45) days after the expiration or sooner termination of the Term the
Letter of Credit and any security deposit, to the extent not applied, shall be returned to the
Tenant, without interest. For purposes of this Section 2.05, an Event of Default shall also include
any default that is prevented or delayed from ripening into an Event of Default due to Landlord’s
inability to give any required notice or the tolling of any grace or cure period caused by any stay
or injunction arising from the bankruptcy of Tenant.

     In the event of a sale of the Property or lease, conveyance or transfer of the Property,
Landlord shall have the right to transfer the security to the transferee (“New Landlord”) and
Landlord shall thereupon be released by Tenant from all liability for the return of such security;
and Tenant agrees to look to the New Landlord solely for the return of said security. The
provisions hereof shall apply to every transfer or assignment made of the security to a New
Landlord. Tenant further covenants that it will not assign or encumber

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or attempt to assign or encumber the Letter of Credit or the monies deposited herein as
security, and that neither Landlord nor its successors or assigns shall be bound by any assignment,
encumbrance, attempted assignment or attempted encumbrance

Article 3.

Utility Services

     Section 3.01. Electricity. From and after the Commencement Date for each Portion of
the Premises, Tenant agrees to pay, or cause to be paid, as Additional Rent, all charges for
electricity consumed in the applicable Portion of the Premises (or by any special facilities
serving the Premises). Tenant will comply with all contracts relating to any such services.
Tenant’s charges for such utility usage shall be based upon Tenant’s actual usage as determined by
Landlord’s reading of check-meters serving the Premises provided as part of the Finish Work.
Tenant shall make monthly payments of Additional Rent on account of electricity, in advance, on the
applicable Commencement Date and the first of each month thereafter equal to one-twelfth (1/12) of
the annual amount of such Additional Rent reasonably projected by Landlord, based upon prior usage
at the relevant building or as projected by Landlord’s engineer, to be due from Tenant (pro-rated
for any partial month at the beginning or end of the term) from time to time. Tenant’s monthly
payments may be reasonably revised by Landlord from time to time so that Tenant’s aggregate monthly
payments shall equal the Additional Rent then projected to be due for the year in question.
Landlord shall provide Tenant with a statement showing Tenant’s actual usage of electricity based
on the reading of Tenant’s check-meters no less often than annually. If the Additional Rent due
for electricity is less than the Additional Rent for electricity paid by Tenant on account of
Landlord’s calculation of estimated electrical charges, Landlord shall either promptly refund to
Tenant the difference or credit same against Rent next due from Tenant. If the Additional Rent due
for electricity is more than Landlord’s calculation of estimated electrical charges, Tenant shall
pay such amount to Landlord within 30 days following receipt of the bill therefor. If such usage
is not separately or check-metered from time to time, such usage and billing shall be based upon
the reasonable estimate of Landlord’s consulting engineer. If Tenant is directed by Landlord to
make payments directly to the utility company for separately metered electricity, then Tenant shall
pay such bills directly to the utility company, Tenant shall contract directly for electric
service, and shall pay all bills for such utility service as and when due. Tenant shall pay all
costs associated with obtaining the electricity service, including costs for equipment
installation, maintenance and repair; exit fees, stranded cost charges, and the like.

     Section 3.02. Other Landlord Services. Landlord shall provide Tenant with access to
the Premises, the Building and the parking areas serving the Building 24 hours per day, 365 days
per year, subject to matters described in Section 20.14 and Landlord’s reasonable security
measures, and subject to Landlord’s right to prohibit, restrict or limit access to the Building or
the Premises in emergency situations if Landlord determines, in its reasonable discretion, that it
is necessary or advisable to do so in order to prevent or protect against death or injury to
persons or damage to property. Landlord agrees to furnish to the Premises the services, and for
the

- 17 -

 

periods, set forth on Exhibit 3.02 (Tenant paying for such services as Operating
Expenses). All other services necessary for the use, occupancy or operation of the Premises, or to
maintain the same in good condition and repair (except to the extent set forth in Section 7.01,
below), shall be provided by Tenant. In the event of an unanticipated maintenance or repair cost
that is incurred by Landlord as an Operating Expense, Landlord may notify Tenant upon determining
the maintenance or repair is needed and, if requested by Landlord, Tenant shall pay the reasonable
cost thereof to Landlord within thirty (30) days after request in addition to the estimated monthly
payments for Operating Expenses under Section 2.02 and the additional payment shall be credited
against the total amount of Operating Expenses due under Section 2.02 for the year in question.
Landlord shall not be required to provide services which exceed the capacity of the building
systems serving the Premises and shall not be required to act (or prevented from acting) in any
manner which might create unsafe conditions, violate applicable legal requirements, or be
inconsistent with standards for the operation of comparable institutionally-financed mixed use
office, laboratory and research and development buildings. In any event, subject to Section 7.06
below, Landlord’s obligation to provide such services shall be subject to interruption due to any
act or omission of Tenant (including a failure to pay for utilities), accident, to the making of
repairs, alterations or improvements (other than those due to the willful misconduct of Landlord),
to labor difficulties, to trouble in obtaining fuel, electricity, service or supplies from the
sources from which they are usually obtained for such building, governmental restraints, or to any
cause beyond the Landlord’s reasonable control. In the event of any such disruption or
interruption (other than an act or omission of Tenant) prior to the time when Tenant is responsible
for providing such services, Landlord will use diligent efforts to restore the services, or to
cause the services to be restored, as promptly as reasonably possible. In no event shall Landlord
be liable for any interruption or delay in any of the above services for any of such causes except
as provided in Section 7.06.

     Normal Building hours of operation are Monday through Friday, 8 a.m. to 6 p.m., and Saturday 8
a.m. to 1 p.m., exclusive of state and federal holidays and such other days as Landlord may
reasonably designate as Building holidays (e.g. the day after Thanksgiving).

     Section 3.03. Facilities Management Rights.

               (a) So long as an Event of Default does not then exist, Tenant shall have the right to assume
all or any portion of the on-site management services with respect to the Building systems serving
the Premises described on Exhibit 3.03-1 commencing on a date no earlier than the initial
Commencement Date. If Tenant desires to assume all or any portion of such on-site management
responsibilities pursuant to this Section 3.03, Tenant shall notify Landlord in writing (a
“Facilities Management Notice”) at least sixty (60) days prior to the first day of the
month in which Tenant intends to assume such management responsibilities and identify by reference
to Exhibit 3.03-1 the responsibilities to be assumed. In connection with any such change
in management, the parties shall cooperate and coordinate with each other so as to effect a smooth
transition and transfer of information and responsibility. During any period that Tenant is
exercising its facilities management rights pursuant to this Section 3.03, the provisions of
Exhibit 3.03-2 shall apply.

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     Tenant shall have the right voluntarily to terminate any portion of its management services
under this Section 3.03 and to relinquish all or any portion of such services under this
Section 3.03 upon sixty (60) days notice and may subsequently again exercise its management rights
hereunder (in whole or in part) provided that the conditions set forth in this Section 3.03 are
then satisfied and more than twelve (12) months have elapsed following the effective date of the
termination of the applicable portion of its management services. If Landlord terminates Tenant’s
management services pursuant to the provisions of Exhibit 3.03-2, then Tenant shall have no
further right to manage any portion of the Building under this Section 3.03. In no event shall
Tenant, in the exercise of its rights under this Section 3.03, be permitted to assume the
management of areas or facilities of the Building serving tenants other than Tenant.

               (b) During such time as Tenant is exercising its facilities management rights pursuant to this
Section 3.03, Tenant will cooperate and work with Landlord to manage the same cooperatively with
the remainder of the Property. In all events, Tenant shall be fully responsible for all costs and
expenses of facilities management under this Section, subject to reimbursement for capital
expenditures as set forth below. Tenant’s rights under this Section 3.03 shall be personal to the
Tenant originally named hereunder. In no event may Tenant’s facilities management rights pursuant
to this Section 3.03 be transferred to or exercised by any other transferee.

     Notwithstanding anything in this Lease to the contrary, so long as Tenant is exercising its
facilities management rights pursuant to this Section 3.03, Tenant will maintain, repair and
replace, at its sole cost and expense (subject to reimbursement with respect to capital
expenditures as set forth below) portions of the Building as further described on Exhibit
3.03-1 and designated in Tenant’s Facilities Management Notice (the “Self-Managed
Components”) and Landlord shall, during such period, have no obligation to maintain, repair, or
replace the Self-Managed Components. If any element of the Self-Managed Components cannot be fully
repaired or restored, and Landlord authorizes replacement of such item or replacement, or such
replacement item is included in an Approved Budget (as defined in Exhibit 3.03-2) Tenant
shall replace it at Tenant’s cost even if the benefit or useful life of such replacement extends
beyond the term of this Lease and Landlord shall reimburse Tenant for such costs to the extent that
such costs are capital expenditures that would not have been includable in Operating Expenses
payable by Tenant under this Lease. Landlord shall reimburse Tenant for the costs set forth in the
preceding sentence by paying such costs within 30 days after receiving Tenant’s invoice therefor.
If Landlord pays costs for capital expenditures when invoiced under this paragraph and Tenant
subsequently exercises an option to extend the term in accordance with this Lease, Tenant shall
reimburse Landlord for all such costs allocable to the extension term or terms (to the extent that
such costs would have been includable in Operating Expenses payable by Tenant) within 30 days after
written request by Landlord made at any time after Tenant exercises the applicable extension
option. Landlord’s and Tenant’s obligations under the prior two sentences shall survive the
expiration of the term.

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Article 4.

Insurance

     Section 4.01. Compliance with Property Insurance. The Tenant shall not permit any use
of the Premises which will make voidable any insurance on the Property, or on the contents of said
property, or which shall be contrary to any law or regulation from time to time established by the
Insurance Services Office, or any similar body succeeding to its powers. The Tenant shall, on
demand, reimburse the Landlord in full for its allocable share of any extra insurance premiums
caused by the particular use or manner of use of the Premises by Tenant.

     Section 4.02. Tenant’s Required Insurance. The Tenant shall maintain with respect to
the Premises and the property of which the Premises are a part, the following insurance:

               (a) Commercial general liability insurance, including Broad Form Project Damage and
Contractual Liability, with respect to the Premises, their use, occupancy and operation, under
which Tenant is the named insured and Landlord, Landlord’s managing agent, any mortgagee, the
association of unit owners under the Reservoir Woods Primary Condominium, The Prudential Insurance
Company of America, and any Landlord agents or contractors (provided that Landlord has identified
such mortgagee, agents and/or contractors by notice to Tenant) are named as additional insureds
with respect to their vicarious liability for covered claims arising from Tenant’s use or occupancy
of the Premises or the Property. Such coverage shall be written on an occurrence basis, with the
following minimum limits: General Aggregate $2,000,000.00; Products/Completed Operations Aggregate
$2,000,000.00; Each Occurrence $1,000,000.00; Personal and Advertising Injury $1,000,000.00;
Medical Payments $5,000.00 per person. In addition, Tenant shall maintain  Umbrella/Excess
Liability insurance on a following form basis with the following minimum limits: General Aggregate
$5,000,000.00; Each Occurrence $5,000,000.00;

               (b) Commercial property insurance on an “all risk” basis, and specifically including sprinkler
leakages, vandalism, and malicious mischief and plate glass damage covering all property of every
description owned or brought into the Premises by Tenant, its employees, agents, contractors,
subtenants, or assignees including stock-in-trade, furniture, fittings, installations, alterations,
additions, partitions and fixtures or anything in the nature of a leasehold improvement made or
installed by or on behalf of the Tenant, including without limitation any Tenant Work and the
Finish Work, in an amount of not less than one hundred percent (100%) of the full replacement cost
thereof as shall from time to time be reasonably approved by Landlord in form satisfactory to
Landlord in its reasonable discretion and plate glass insurance coverage covering all plate glass
within the Premises. Landlord shall be named as loss payee on such property insurance to the
extent of its interest;

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               (c) Policies of insurance against loss or damage arising from incidents relating to the
air-conditioning and/or heating system, electrical systems, steam pipes, steam turbines, steam
engines, steam boilers, other pressure vessels, high pressure piping and machinery, if any,
installed in, or serving, the Premises in an amount satisfactory to Landlord in its reasonable
discretion;

               (d) Worker’s compensation and occupational disease insurance with statutory limits and
Employer’s Liability insurance with the following limits: Bodily injury by disease per person
$1,000,000.00; Bodily injury by accident policy limit $1,000,000.00; Bodily injury by disease
policy limit $1,000,000.00;

               (e) Business automobile liability insurance including owned, hired and non-owned automobiles,
in an amount not less than One Million Dollars ($1,000,000) combined single limit per occurrence,
with such commercially reasonable increases as Landlord may require from time to time;

               (f) Business interruption insurance insuring interruption or stoppage of Tenant’s business at
the Premises for a period of not less than twelve (12) months; and

               (g) with increases in the foregoing limits, and any other form or forms of insurance as
Landlord may reasonably require from time to time, with any other form(s) of insurance in amounts
and for insurable risks (on commercially reasonable terms) against which a prudent tenant would
protect itself to the extent landlords of comparable buildings in the vicinity of the Property
require their tenants to carry such other form(s) of insurance.

     Each policy of insurance required under this Section 4.02 shall be issued by companies rated
not less than A-/X by Best’s Rating Service (or its successor) or otherwise acceptable to Landlord
in the Landlord’s reasonable discretion and licensed to do business in The Commonwealth of
Massachusetts, and shall be noncancellable with respect to Landlord and any mortgagee (provided
that Landlord has identified such mortgagee by notice to Tenant), without thirty (30) days prior
notice to Landlord and such mortgagee. Tenant shall deliver to Landlord and any mortgagee
(provided that Landlord has identified such mortgagee by notice to Tenant) certificate(s) of
insurance evidencing the coverage required hereunder upon commencement of the term of this Lease
and no later than thirty (30) days prior to the expiration of the coverage evidenced by a prior
certificate. All such insurance certificates shall provide that such policy shall not be canceled
or reduced as to coverage or amount without at least thirty (30) days prior written notice to each
insured named therein. Tenant’s liability insurance policy shall be primary with respect to all
claims for which Tenant is to indemnify Landlord under Article 12. All furnishings, fixtures,
equipment, effects and property of Tenant and of all persons claiming through Tenant which from
time to time may be on the Premises or Property or in transit thereto or therefrom (“Tenant
Property”) shall be at the sole risk of Tenant, and if the whole or any part thereof shall be
destroyed or damaged by fire, water or otherwise, or by the leakage or bursting of water pipes, or
other pipes, by theft or from any other cause, no part of said loss or damage is to be charged to
or be borne by Landlord.

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     Section 4.03. Landlord’s Required Insurance. The Landlord shall maintain at least
Seven Million ($7,000,000.00) Dollars of commercial general liability insurance (including
so-called umbrella coverage) covering the Building. Landlord shall maintain physical damage and
casualty insurance on an “all risk” basis on the Building (excluding furnishings, fixtures,
equipment and other personal property of Tenant) in the amount of the full replacement cost of the
Premises (other than Tenant Work and any Finish Work) as reasonably determined by Landlord, and
shall also maintain boiler and rent loss insurance in amounts required by Landlord’s mortgage
lender or otherwise reasonably determined by Landlord. Landlord’s insurance shall be issued by
companies rated not less than A-/X by Best’s Rating Service (or its successor) and licensed to do
business in The Commonwealth of Massachusetts. Landlord shall cause the casualty insurance
replacement cost coverage to be updated as reasonably necessary. Any or all of Landlord’s
insurance may be provided by blanket coverage maintained by Landlord or any affiliate of Landlord
under its insurance program for its portfolio of properties. Landlord may maintain other coverages
in such amounts as are required by Landlord’s mortgage lender or otherwise as reasonably determined
by Landlord.

     Section 4.04. Tenant Work Insurance. In addition, during the performance of any
Tenant Work, in addition to the above coverage required to be maintained by Tenant, Tenant shall
cause the general contractor performing any work in the Premises (and the general contractor shall
cause its subcontractors) to carry: (a) workers’ compensation and occupational disease insurance in
statutory amounts; (b) employer’s liability insurance with a limit of not less than One Million
Dollars ($1,000,000); (c) commercial general liability insurance, including personal injury and
property damage, on an occurrence basis in the amount of a combined single limit of not less than
One Million Dollars ($1,000,000.00) for each occurrence, such limit to be increased to Five Million
Dollars ($5,000,000.00) if the cost of the work exceeds One Million Dollars ($1,000,000.00); and
(d) all risk installation floater insurance (on the complete value/full coverage form) to protect
Landlord’s interest and that of Tenant, contractors and subcontractors during the course of the
construction, with limits of not less than the total replacement cost of the completed improvements
under construction. Such contractor insurance policies shall be endorsed to include Landlord, The
Prudential Insurance Company of America, the condominium association, Landlord’s managing agent,
any mortgagee, and any other third party providing services to the Building (provided that Landlord
has identified such mortgagee and/or third parties by notice to Tenant) as additional insureds.

     Section 4.05. Waiver of Subrogation. Any property insurance carried by either party
under Sections 4.02(b), 4.02(c) or 4.03 shall, if it can be so written without additional premium
or with an additional premium which the other party agrees to pay, include a clause or endorsement
denying to the insurer rights of subrogation against the other party to the extent rights have been
waived by the insured hereunder prior to occurrence of injury or loss. Each party, notwithstanding
any provisions of this Lease to the contrary, hereby waives any rights of recovery against the
other for injury or loss due to hazards covered by property insurance carried (or required to be
carried) by the party suffering the injury or loss to the extent of the coverage provided (or to be
provided) thereunder.

     Section 4.06. Certificates of Insurance. Within fifteen (15) days of request, each
party shall provide the other with certificates of all insurance maintained or required to be
maintained under this Lease.

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Article 5.

Use of Premises

     Section 5.01. Permitted Use. The Tenant covenants and agrees to use the Premises only
for the purposes of business and professional offices, research labs, and ancillary and subordinate
uses customarily undertaken as accessory uses in connection therewith including without limitation
an animal care facility not to exceed Tenant’s ACF Share (as defined below) of the Premises
(measured in rentable square feet), and for no other purpose (the “Permitted Use”).

     “Tenant’s ACF Share” shall mean the percentage of the Premises that is proportionate
to the percentage of accessory animal care facility space permitted in the Building from time to
time under applicable laws, codes and ordinances, which, as of the date hereof, is 20%. If Tenant
is then utilizing all or substantially all of Tenant’s ACF Share, and provided that no Event of
Default is then continuing, then, following the initial lease-up of the entire Building, upon
Tenant’s reasonable request from time to time Landlord shall allocate any then-excess animal care
facility rights at the Building (i.e. rights in excess of Tenant’s ACF Share not then allocated to
other tenants) to Tenant as an increase in the foregoing limit so long as such use, as increased,
remains an accessory use ancillary and subordinate to Tenant’s other activities in the Premises.

     Section 5.02. Tenant’s Conduct; Hazardous Materials.

               (a) Tenant will not make or permit any occupancy or use of any part of the Premises for any
hazardous, offensive, dangerous, noxious or unlawful occupation, trade, business or purpose or any
occupancy or use thereof which is contrary to any law, by-law, ordinance, rule, permit or license,
and will not cause, maintain or permit any nuisance in, at or on the Premises; provided, however,
that the Permitted Use, if conducted in conformance with the terms of this Lease, all applicable
legal requirements, and customary standards for first class office, laboratory and research and
development space, shall not be deemed to be a hazardous, offensive, dangerous, or noxious
occupation, trade, business or purpose or a nuisance unless it adversely affects tenants or
occupants outside the Premises. Tenant shall not conduct or permit any foreclosure or going out of
business auctions, or sheriff’s sales, at the Property. Tenant shall not place any loads upon the
floors, walls, or ceiling which endanger the structure, or place any Hazardous Materials in the
drainage system of the Premises or Property (other than Hazardous Materials in compliance with
Environmental Laws applicable to the drainage system of the Premises) or overload existing
electrical or other mechanical systems. Tenant shall not use any machinery or equipment in the
Premises that causes excessive noise or vibration perceptible from the exterior of the Premises, as
reasonably determined by Landlord, or that unreasonably interferes with the use or enjoyment of the
Property by other tenants or lawful occupants. No waste materials or refuse shall be dumped upon
or permitted to remain outside of the Premises except in trash containers placed inside exterior
enclosures designated by Landlord for that purpose. No sign, antenna or other structure or thing
shall be erected or placed on the Premises or any part of the exterior of any building or on the
land comprising the Property or erected so as

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to be visible from the exterior of the building containing the Premises except as expressly
permitted pursuant to Section 20.12 of this Lease. Tenant will not cause or permit any waste,
overloading, stripping, damage, disfigurement or injury of or to the Property, the Premises, or any
part thereof.

               (b) Tenant agrees not to generate, store or use any Hazardous Materials (as hereinafter
defined) on or about the Premises, except (a) those used by Tenant in its general office operations
and janitorial services, in both cases limited to such Hazardous Materials in such amounts as are
customarily used in general office uses and for janitorial service provided to general office uses,
and (b) those used in connection the Permitted Uses, and in each case only in compliance with any
and all Environmental Laws (as defined below) and, in each of (a) and (b), in a manner consistent
with the use and operation of a biotechnology laboratory below a so-called BL-3 level (or such
lower level as is required pursuant to applicable Environmental Laws) in a mixed-use setting.
Tenant shall provide Landlord, upon Landlord’s written request, with copies of all Material Safety
Data Sheets (“MSDS”) for Hazardous Materials used or stored in the Premises. Following the
initial occupancy of the Premises, Tenant agrees to notify Landlord prior to introducing any
Hazardous Materials into the Premises that require special precautions or facilities materially
different from Tenant’s initial operations in the Premises. In all events, Tenant agrees not to
release or permit Tenant or Tenant’s contractors, subtenants, licensees, invitees, agents, servants
or employees or others for whom Tenant is legally responsible (collectively, with Tenant,
“Tenant Responsible Parties”) to release any Hazardous Materials on the Premises in
violation of or that requires reporting under any Environmental Law, and not to dispose of
Hazardous Materials (a) on the Premises or (b) from the Property to any other location except a
properly approved disposal facility and then only in compliance with any and all Environmental Laws
regulating such activity, nor permit any occupant of the Premises to do so. In all events Tenant
shall comply with all applicable provisions of the standards of the U.S. Department of Health and
Human Services as further described in the USDHHS publication Biosafety in Microbiological and
Biomedical Laboratories as it may be further revised, or such nationally recognized new or
replacement standards as may be reasonably selected by Landlord.

               (c) For purposes of this Lease, “Hazardous Materials” shall mean any substance
regulated under any Environmental Law, including those substances defined in 42 U.S.C. Sec.
9601(14) or any related or applicable federal, state or local statute, law, regulation, or
ordinance, pollutants or contaminants (as defined in 42 U.S.C. Sec. 9601(33), petroleum (including
crude oil or any fraction thereof), any form of natural or synthetic gas, sludge (as defined in 42
U.S.C. Sec. 6903(26A), radioactive substances, hazardous waste (as defined in 42 U.S.C. Sec.
6903(27)) and any other hazardous wastes, hazardous substances, contaminants, pollutants or
materials as defined, regulated or described in any of the Environmental Laws. As used in this
Lease, “Environmental Laws” means all federal, state and local laws relating to the
protection of the environment or health and safety, and any rule or regulation promulgated
thereunder and any order, standard, interim regulation, moratorium, policy or guideline of or
pertaining to any federal, state or local government, department or agency, including but not
limited to the Comprehensive Environmental Response, Compensation and Liability Act of 1980, as
amended, the Superfund Amendments and Reauthorization Act of 1986, the Clean Water Act, the Clean
Air Act, the Toxic Substances Control Act, the Occupational Safety and Health Act, the

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Federal Insecticide, Fungicide and Rodenticide Act, the Marine Protection, Research, and
Sanctuaries Act, the National Environmental Policy Act, the Noise Control Act, the Safe Drinking
Water Act, the Resource Conservation and Recovery Act, as amended, the Hazardous Material
Transportation Act, the Refuse Act, the Uranium Mill Tailings Radiation Control Act and the Atomic
Energy Act and regulations of the Nuclear Regulatory Agency, Massachusetts General Laws Chapters
21C and 21E, and any other state and local counterparts or related statutes, laws, regulations, and
order and treaties of the United States.

               (d) Tenant shall permit Landlord and Landlord’s agents, representatives and employees,
including, without limitation, legal counsel and environmental consultants and engineers, access to
the Premises during the term upon at least twenty-four (24) hours’ prior notice (which may be
verbal, and no such prior notice is necessary in the event of an emergency threatening life or
property) to Don Reitano (Director of Corporate Operations) or such other employee of Tenant as
Tenant may designate to Landlord from time to time for purposes of conducting environmental
assessments; provided, however, that such assessments may only be conducted if (i) Landlord has
reason to believe that there has been a release or threat of release of Hazardous Materials in a
reportable quantity at the Premises or arising from Tenant’s activities at the Property or (ii)
requested by an actual or prospective mortgage lender, purchaser or equity investor. Landlord
shall permit Tenant or Tenant’s representatives to be present during any such assessment, and any
investigation, testing or sampling. In making any such entry, Landlord shall avoid materially
interfering with Tenant’s use of the Premises, and upon completion of Landlord’s assessment,
investigation, and sampling, shall substantially repair and restore the affected areas of the
Premises from any damage caused by the assessment. Such assessment shall be at Landlord’s expense,
provided that if the assessment shows that a release of Hazardous Materials in violation of this
Lease has occurred, then Landlord’s actual, reasonable, out-of-pocket costs relating to such
assessment shall be reimbursed by Tenant. Tenant shall pay for all costs reasonably incurred by
Landlord, for independent consultants or otherwise, in connection with inspections, investigations,
and/or response actions concerning a release or threat of release of Hazardous Materials at the
Premises.

               (e) Tenant covenants to use best industry practices in the conduct of all laboratory
operations and the storage, use, treatment, and disposal of Environmental Substances at the
Premises. Tenant shall prepare a written environmental contingency plan sufficient to comply with
applicable laws, regulations, codes and ordinances and good practice for first class laboratory
space (“Tenant’s Environmental Contingency Program”) and shall revise the same from time to
time as reasonably necessary because of changes in operations within the Premises, changes in
applicable legal requirements, and changes in customary practice for environmental contingencies in
first class laboratory space. Tenant shall implement the Environmental Contingency Program as
necessary in accordance with the approved plan (as it may be revised) and shall, within 14 days
after Landlord’s written request, provide Landlord with copies of all reports and documentation
prepared in connection therewith. Within 14 days after Landlord’s written request, Tenant shall
provide Landlord with copies of any routine safety audits conducted by Tenant in the ordinary
course of Tenant’s business. Landlord may from time-to-time undertake an environmental audit to
assess the compliance of Tenant with applicable Environmental Laws if Landlord reasonably believes
that Tenant is not then in material compliance with such Environmental Laws or if there is any
release of Hazardous Materials required to be reported under any Environmental Law that arises

- 25 -

 

out of the use, operation, or occupancy of the Premises or Premises by Tenant or any Tenant
Responsible Parties during the term of this Lease and any further period during which Tenant or any
Tenant Responsible Party retains use, operation or occupancy of the Premises (a “Tenant’s
Release”). Any such audit shall be at Tenant’s cost and expense if the results of such audit
identify any such material non-compliance by Tenant or any Tenant’s Release. In addition, Tenant
shall investigate, assess, monitor and report as required by applicable Environmental Law, at
Tenant’s sole cost and expense, any Tenant’s Release. Further, Tenant shall remediate, in
compliance with applicable Environmental Laws, at Tenant’s sole cost and expense, any Tenant’s
Release requiring Response Action (as defined in 310 C.M.R. 40.0000). Tenant shall submit to
Landlord for Landlord’s prior approval a work plan outlining in reasonable detail any Remedial Work
to be performed by Tenant hereunder (the “Remedial Work Plan”). Landlord shall not unreasonably
withhold or delay its approval of such Remedial Work Plan if (i) it complies with all applicable
Environmental Laws; and (ii) the Remedial Work outlined therein reasonably appears sufficient to
remediate the releases to the level provided for in this Section 5.02(d). If Tenant is obligated
to remediate a Tenant’s Release under this Lease, Tenant shall be obligated to remediate the
Tenant’s Release to a level that will permit the portion of the Property to be used for first class
office, laboratory, and research and development uses under applicable laws, statutes, codes, and
ordinances, whether now existing or hereafter enacted. Tenant shall make available to Landlord
copies of drafts of any submittals to governmental authorities in connection with the Remedial Work
for Landlord’s review and comment at least three (3) business days prior to such submittal, and
Tenant shall consider in good faith and incorporate as Tenant reasonably deems appropriate
Landlord’s comments thereon. Tenant shall sign any manifests or other documents as the waste
generator for any Hazardous Materials it disposes of or sends off site or otherwise arising from a
Tenant’s Release. This Subsection shall survive the term of this Lease and shall be subject to the
provisions of Section 5.03. Tenant’s remediation obligation set forth in this Subsection shall not
limit Landlord’s right to damages, if any, which Landlord may incur due to any unremediated
Hazardous Materials resulting from a Tenant’s Release.

               (f) Tenant shall pay for all costs reasonably incurred by Landlord, for independent
consultants or otherwise, in connection with inspections, investigations, and/or response actions
concerning a release of Hazardous Materials at the Premises (to the extent caused by Tenant, Tenant
’s agents, contractors or employees, or persons acting by, through or under Tenant ).

               (g) Tenant may require that any representative of Landlord entering into a secured portion of
the Premises identified by Tenant to Landlord in advance as containing proprietary information for
the purposes set forth in this Section 5.02 execute a confidentiality agreement with respect to
Tenant’s proprietary information, provided, however, that such agreement is subject to Landlord’s
prior approval (not to be unreasonably withheld). Landlord agrees to hold any proprietary
information identified by Tenant and supplied to Landlord pursuant to this Section 5.02(b)-(f)
(“Confidential Information”) in confidence, subject to disclosures to the extent that such
disclosure is required by law or court order or by discovery rules in any legal proceeding.
Notwithstanding the foregoing, Landlord may disclose such Confidential Information to its lenders,
attorneys, and consultants in connection with the financing or sale of the Property or Landlord’s
review of such information provided that such lenders, attorneys

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and consultants are informed of Landlord’s obligations hereunder and do not disclose such
Confidential Information in a manner that would not be permitted hereunder.

               (h) Tenant shall have no right to use the area identified on Exhibit 1.01-1 as “Second
Floor Common Lobby” for any purpose other than (x) code-required emergency access and egress to the
Premises or (y) if a portion of the second floor of the Premises is subleased by Tenant as
permitted by this Lease and requires use of the Second Floor Common Lobby as a primary entry for
such subleased premises.

     Section 5.03. Hazardous Materials Indemnity. Tenant shall indemnify, defend with
counsel reasonably acceptable to Landlord and hold Landlord, Landlord’s managing agent and any
mortgagee of the Premises, and any other Indemnitees (as defined in Section 12.01) fully harmless
from and against any and all liability, loss, suits, claims, actions, causes of action,
proceedings, demands, costs, penalties, damages, fines and expenses, including, without limitation,
attorneys fees, consultants’ fees, laboratory fees and clean up costs, and the costs and expenses
of investigating and defending any claims or proceedings, resulting from, or attributable to
(i) the presence of any Hazardous Materials on the Property or the Premises arising from the action
or negligence of Tenant, its officers, employees, contractors, and agents, or arising out of the
generation, storage, treatment, handling, transportation, disposal or release by such party (or
their respective officers, employees, contractors, agents or invitees) of any Hazardous Materials
at or near the Property or the Premises, (ii) any violation(s) by Tenant or its officers,
employees, contractors, agents or invitees of any applicable law regarding Hazardous Materials, and
(iii) any breach by Tenant of the obligations set forth in Sections 5.02(b) and (d) of this Lease.

     The provisions of this Section 5.03 shall survive the expiration or earlier termination of
this Lease.

     Section 5.04. Rules and Regulations. Rules and regulations delivered to Tenant in
writing, provided the same are not inconsistent with or in limitation of the provisions of this
Lease, which in the judgment of the Landlord are reasonable, shall be observed by the Tenant and
its employees, and Tenant shall use reasonable efforts to cause its agents, contractors, customers
and business invitees to comply therewith. Tenant acknowledges that the rules and regulations may
include provisions necessary to comply with requirements of governmental approvals. Landlord
agrees that the rules and regulations shall not be applied against Tenant in a discriminatory
manner. Tenant agrees that Landlord shall not be liable to Tenant for the failure of other tenants
to comply with the rules and regulations.

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Article 6.

Compliance with Legal Requirements

     Section 6.01. Compliance with Legal Requirements. Throughout the term of this Lease,
Tenant, at its sole cost and expense, will promptly comply with all requirements of law, code,
regulation or ordinance related in any way to its use and occupancy of the Premises, including
without limitation any Tenant Work, and will procure and maintain all permits, licenses and other
authorizations required with respect to the Premises, or any part thereof, for the lawful and
proper operation, use and maintenance of the Premises or any part thereof. Notwithstanding the
foregoing to the contrary, Tenant shall have no obligation to bring elements of the foundations,
exterior walls, structural floors, and roof of the Building, and the portions of the electrical,
heating, ventilation and air conditioning systems of the Building that serve other tenants,
(collectively, the “Base Building”) into compliance with applicable laws, codes,
regulations or ordinances except to the extent such compliance is required as a result of Tenant
Work, Tenant’s particular use of the Premises, as opposed to the Permitted Use, generally, the
exercise of Tenant’s facilities management rights pursuant to Section 3.03 of this Lease, Tenant’s
negligence or willful misconduct (subject to the provisions of Section 4.05), or Tenant’s default
under this Lease. Landlord shall have the obligation to bring elements of the Base Building into
compliance with applicable laws (including, without limitation, Environmental Laws as hereinafter
defined, but subject to the other provisions of this lease governing Tenant’s use of Hazardous
Materials) except to the extent such compliance is required as a result of Tenant Work, Tenant’s
particular use of the Premises, as opposed to the Permitted Use, generally, Tenant’s negligence or
willful misconduct (subject to the provisions of Section 4.05), or Tenant’s default under this
Lease.

Article 7.

Construction, Condition, Repairs and Maintenance of Premises

     Section 7.01. Base Building Work. Landlord shall perform certain base building
modifications to accommodate the demising of the Premises, as further described below, in a good
and workmanlike manner, using new materials of first quality, and shall comply with applicable laws
and all applicable ordinances, orders and regulations of governmental authorities. The work
described in the immediately preceding sentence shall be performed in all material respects in
accordance with the scope of work and schematic plan attached as Exhibit 7.01 (the
“Base Building Work”), provided that Landlord may modify the design of the Base Building
Work from time to time (subject to the provisions of the immediately following paragraph) so long
as the modification (i) does not affect the utility, quality, or appearance of the Base Building
Work in any material respect, (ii) does not materially increase the cost of the Finish Work (except
as provided below), (iii) will not materially interfere with Tenant’s use of the Premises, (iv)
does not involve a material reduction in the quality of materials to be incorporated in the Base
Building Work, (v) will not result in any material diminution of the rentable area of the Premises,
and (vi) will not materially and adversely affect the building service systems

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and equipment serving the Premises (collectively, the “Tenant Approval Not Required
Standards”). In addition to the requirements described in Exhibit 7.01, Landlord’s
Base Building Work shall be further described in final construction documents that shall be
consistent with a first class suburban office building and the initial scope of work and schematic
plan for the Base Building Work pursuant to the schedule for Landlord’s Deadlines set forth on
Schedule 2 to Exhibit 7.02, attached. Landlord shall provide Tenant with copies of
the construction documents for Tenant’s review and comment. Tenant shall review and comment on
such plans within five (5) business days following the delivery of such plans to Tenant. If Tenant
fails to review and comment on such plans within such five (5) business day period, then Tenant
shall be deemed to have waived its right to comment.

     From time to time during the construction of the Base Building Work directly affecting the
Building and the Finish Work, Landlord shall allow Tenant’s authorized representatives to review
and make copies of plans and specifications including all changes thereto and generally to review
the progress of Landlord Work. Such reviews shall be scheduled so as not to interfere with the
conduct of Landlord Work. Tenant shall be provided with copies of all changes or supplements to
the construction plans for the Base Building Work when the same are given to Landlord’s contractor.

     Section 7.02. Finish Work. Landlord shall construct Tenant’s initial improvements to
prepare the Premises for Tenant’s occupancy in accordance with Exhibit 7.02, attached.

     Section 7.03. Landlord Maintenance Obligations.

               (a) Except as otherwise provided in this Lease, including without limitation if Tenant has
assumed responsibility for such services pursuant to a Facilities Management Notice, throughout the
term of this Lease, but subject to the terms of Article 11, Landlord shall make such repairs to the
Base Building and the common areas of the Property, including all elevators (even the Tenant
Exclusive Elevators), as may be necessary to keep them in good condition in accordance with
standards for a first class office, laboratory and research and development building in the
suburban Boston area, reasonable wear and tear excepted.

               (b) Landlord shall prepare, or cause to be prepared, a written operations and maintenance plan
for any heating, ventilation and air-conditioning systems serving the Premises in common with other
parts of the Building from time-to-time and shall provide Tenant with a copy of such O&M Plan.
Landlord may amend or modify the O&M Plan from time to time in consultation with Tenant. If, in
Tenant’s good faith determination, the O&M Plan does not comply with standards for first class
office, laboratory and research and development buildings in the suburban Boston area, Tenant may
object to such O&M Plan with specific comments and suggestions for revisions given within 20 days
following receipt of such plan from Landlord. If the parties are unable to resolve any disputes
regarding whether the O&M Plan meets the applicable standard within 60 days thereafter, despite
good faith efforts to do so, then either party may submit such dispute to arbitration in accordance
with the last paragraph of Section 14.07(b) of this Lease (except that the arbitrator shall be a
mechanical, engineering and plumbing engineer with at least 20 years’ experience in the design and

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operation of HVAC systems in first class office and laboratory buildings in the greater Boston
area). In connection with the operation and repair of such systems, Tenant shall have the
appurtenant right to monitor, access and inspect such systems to confirm that they are being
operated and maintained as required hereunder.

     Section 7.04. Tenant Maintenance Obligations. Throughout the term of this Lease, and
except as provided in Section 7.01, but subject to the terms of Article 11, Tenant shall clean,
maintain and repair the Premises, and any Tenant Work (including the Finish Work), the utility
meters serving only the Premises, the heating ventilation and air-conditioning units located on the
roof of the Building as of the date of this Lease and serving exclusively the second and third
floors of the Premises, and any other Building systems to the extent exclusively serving the
Premises, all in accordance with standards for a first class office, laboratory and research and
development building in the suburban Boston area, reasonable wear and tear excepted.

     Section 7.05. Landlord’s Right of Entry. Landlord, or agents or prospective
investors, lenders or purchasers of Landlord, at reasonable times, reserves the right to enter upon
the Premises to examine the condition thereof, to make repairs, alterations and additions as
Landlord is required or permitted under the terms of this Lease, and at any reasonable time within
twelve (12) months before the expiration of the term to show the Premises to prospective tenants.
In connection with such access, Landlord shall not unreasonably interfere with the operation or
work at the Premises and shall give Tenant reasonable prior written notice where practicable
(except in the event of an emergency, in which event such notice shall be as prompt as possible
under the circumstances and may be oral) of Landlord’s intent to access the Premises.

     Section 7.06. Service Interruptions. In the event that there shall be an
interruption, curtailment or suspension of any service required to be provided by Landlord pursuant
to Exhibit 3.02 (and no reasonably equivalent alternative service or supply is provided by
Landlord) (but not including any services that are then subject to Tenant’s facilities management
rights pursuant to the exercise of Tenant’s rights under Section 3.03), or if Landlord fails to
commence and diligently prosecute to completion any repair or maintenance required by Landlord
under this Lease within applicable notice and cure periods, that shall materially interfere with
Tenant’s use and enjoyment of a material portion of the Premises, and Tenant actually ceases to use
the affected portion of the Premises (any such event, a “Service Interruption”), and if
(i) such Service Interruption shall continue for five (5) consecutive business days following
receipt by Landlord of written notice from Tenant describing such Service Interruption (the
“Service Interruption Notice”), (ii)  such Service Interruption shall not have been caused,
in whole or in part, by matters described by Article 11 or by an act or omission in violation of
this Lease by Tenant or by any negligence of Tenant, or Tenant’s agents, employees, contractors or
invitees, and (iii) the cure of the condition giving rise to the Material Service Interruption is
within Landlord’s reasonable control (a Service Interruption that satisfies the foregoing
conditions being referred to hereinafter as a “Material Service Interruption”) then, as
liquidated damages and Tenant’s sole remedy at law or equity, Tenant shall be entitled to an
equitable abatement of Rent, based on the nature and duration of the Material Service Interruption,
the area of the Premises affected, and the then current Rent amounts, for the

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period that shall begin on the commencement of such Service Interruption and that shall end on
the day such Material Service Interruption shall cease.

     Notwithstanding the foregoing, if (w) a Material Service Interruption continues for 180 days
(provided that such 180 day period shall be extended for a period of up to an additional 90 days so
long as Landlord is diligently prosecuting to cure such Material Services Interruption) following
delivery of the Service Interruption Notice, (x) Tenant simultaneously delivered the Service
Interruption Notice to any then-Mortgagee (as defined in Section 10.1), (y) such Mortgagee has not
cured such Material Service Interruption within the period set forth in Section 10.3, and (z) such
Material Service Interruption adversely interferes with Tenant’s operations in either (i) at least
25% of the Premises (measured in rentable square feet) or (ii) any portion of the Lab Portion such
that there are material adverse consequences to critical laboratory operations of Tenant in
progress or planned at the time such Material Service Interruption commenced, then following such
period Tenant shall have the option to terminate this Lease upon thirty (30) days prior written
notice to Landlord and such Mortgagee; provided, however, that if such Material Service
Interruption shall cease prior to the expiration of such thirty (30) day period, then such
termination notice shall be of no force or effect.

     The provisions of this Section 7.06 shall not apply to matters arising out of any casualty or
taking by eminent domain, which events are addressed by Article 11 of this Lease.

Article 8.

Alterations and Additions

     Section 8.01. Tenant Work

               (a) The Tenant shall not make any additional alterations or additions, structural or
non-structural, to the Premises without first obtaining the written consent of Landlord on each
occasion, which consent shall not be unreasonably withheld, conditioned or delayed. Any such
alterations or additions are referred to herein as “Tenant Work”. For non-structural
alterations or additions valued at less than $100,000 which do not affect any of the exterior,
lobbies, elevator, roof, structure, or building systems in or at the Building, Landlord’s consent
shall not be required (“Minor Alterations”) provided, however, that (i) if such Minor
Alteration requires a building permit from the applicable municipal authority, Landlord’s consent
shall be required, provided that such consent shall not be unreasonably withheld, conditioned or
delayed, and (ii) if Landlord’s consent was not obtained therefor, upon the expiration or
termination of this Lease, Tenant shall readapt, repair and restore the affected portion of the
Premises to substantially the condition the same were in prior to such Minor Alteration.
Additionally, Tenant shall give prior written notice to Landlord of any Minor Alteration regardless
of whether Landlord’s consent is required. Wherever consent is required, it shall include
reasonable approval of plans and contractors and the insurance required under Section 4.04. Unless
otherwise approved by Landlord, Tenant

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shall use the structural engineer employed by Landlord for the Building where Alterations affect
Building structure. Tenant shall notify Landlord of all alterations or additions and provide
Landlord with copies of any construction plans therefor whether or not Landlord’s consent is
required. All such allowed alterations, including reasonable third-party costs of review in
seeking Landlord’s approval, shall be made at Tenant’s expense by an Approved Contractor (as
defined below), in compliance with all laws, and be of first class quality. Prior to
commencing any work at the Property other than Minor Alterations or Alterations costing less
than $1,000,000 (such amount decreasing to $250,000 at any time that Tenant fails to meet the
Financial Test) in the aggregate, Tenant shall provide and record bonds or such other security
as is reasonably satisfactory to Landlord sufficient to protect the interests of both Tenant
and Landlord in the Property from any lien arising out of a failure to pay for work performed
for Tenant, and all alterations and additions performed by Tenant, (but excluding Minor
Alterations), shall be performed by an Approved Contractor. Upon the expiration or earlier
termination of this Lease, Tenant shall assign to Landlord (without recourse) all warranties
and guaranties then in effect for all work performed by Tenant at the Premises.

     For purposes of this Section 8.01(a), an “Approved Contractor” shall mean a contractor
or mechanic identified by Tenant in writing, who has been approved by Landlord (such approval not
to be unreasonably withheld, conditioned or delayed).

               (b) Except as set forth below, any alterations or additions made by, for or on behalf of the
Tenant which are permanently affixed to the Premises or affixed in a manner so that they cannot be
removed without defacing or damaging the Premises shall, except as expressly provided in this
paragraph, become property of the Landlord at the termination of occupancy as provided herein. If
Landlord notifies Tenant, in connection with any consent to alterations or additions requested by
Tenant, or in connection with the review and approval of the plans for the Finish Work under
Exhibit 7.02 that Tenant shall be required to remove such alterations or additions or
Finish Work at the expiration of the term of the Lease, or if any such alterations or additions did
not require Landlord’s consent pursuant to the terms hereof, then such alterations or additions or
Finish Work, as applicable, shall be removed by Tenant, at its expense, with minimal disturbance to
the Premises prior to the expiration of the term of the Lease. Notwithstanding the immediately
preceding sentence to the contrary, Landlord may only require Tenant to remove items of Tenant Work
or Finish Work that are above or otherwise inconsistent with the first class nature of the
Building. Tenant’s trade fixtures and personal property and equipment, which are not affixed or
that may be removed with minimal disturbance or repairable damage, may be removed by Tenant during
the term of this Lease, and shall be removed prior to the expiration of the term of the Lease,
provided such disturbance or damage is restored and repaired so that the Premises are left in at
least as good a condition as they were in at the commencement of the term, reasonable wear and tear
excepted. In no event shall any Finish Work funded by the Finish Work Allowance be deemed to be
Tenant’s trade fixtures, personal property or equipment. The Premises shall otherwise be left in
the same condition as at the commencement of the term or such better condition as it may thereafter
be put, reasonable wear, tear and, to the extent Landlord is required to restore the same, damage
by fire or other casualty or taking or condemnation by public authority excepted. Notwithstanding
anything herein or otherwise in this Lease to the contrary, the Tenant emergency generators and
nitrogen tanks paid for directly by Tenant, together with such other items that may be agreed upon
by mutual written agreement of the parties from time to

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time, shall be and remain the personal property of Tenant, shall not be deemed to be Tenant
Work, and Tenant shall have the right to remove the foregoing from the Premises at any time and
from time to time during the term of this Lease.

Article 9.

Discharge of Liens

     Section 9.01. No Liens. Tenant will not create or permit to be created or to remain,
and within ten (10) days after notice from Landlord will discharge or bond off, at its sole cost
and expense and to the reasonable satisfaction of Landlord and any mortgagee, any lien, encumbrance
or charge (on account of any mechanic’s, laborer’s, materialmen’s or vendor’s lien, or any
mortgage, or otherwise) made or suffered by Tenant which is or might be or become a lien,
encumbrance or charge upon the Premises (including Tenant’s leasehold interest therein), Property
or any part thereof, or the rents, issues, income or profits accruing to Landlord therefrom, and
Tenant will not suffer any other matter or thing within its control whereby the estate, rights and
interest of Landlord in the Property or Premises or any part thereof might be materially impaired.
Notice is hereby given that Landlord shall not be liable for any labor or materials furnished or to
be furnished to Tenant in connection with any Tenant Work and that no mechanic’s or other lien for
any such labor or materials shall attach to or affect the estate or interest of Landlord in and to
the Premises or the Property, and, upon Landlord’s request, to the maximum extent permitted by law,
Tenant shall cause any contractor of Tenant to execute and deliver an acknowledgement confirming
the same in such form as Landlord may from time to time reasonably prescribe.

Article 10.

Subordination

     Section 10.01. Lease Subordinate to Mortgages.

               (a) The interest of the Tenant hereunder shall be subordinate to the rights of any holder of a
mortgage or holder of a ground lease of property which includes the Premises (any such holder, a
“Mortgagee”), and executed and recorded subsequent to the date of this Lease, unless such Mortgagee
shall otherwise so elect, subject to the provisions of Section 10.01(f), below; or

               (b) If any Mortgagee shall so elect, this Lease, and the rights of the Tenant hereunder, shall
be superior in right to the rights of such Mortgagee, with the same force and effect as if this
Lease had been executed and delivered, and recorded, or a statutory notice hereof recorded, prior
to the execution, delivery and recording of any such mortgage.

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     Any election as to Subsection (b) above shall become effective upon either notice from such
Mortgagee to the Tenant in the same fashion as notices from the Landlord to the Tenant are to be
given hereunder or by the recording in the appropriate registry or recorder’s office of an
instrument, in which such Mortgagee subordinates its rights under such mortgage or ground lease to
this Lease.

     In the event any Mortgagee shall succeed to the interest of Landlord, whether by judicial or
non-judicial foreclosure or otherwise, at the election of such Mortgagee, Tenant shall, and does
hereby agree to attorn to such Mortgagee and to recognize such Mortgagee as its Landlord and Tenant
shall promptly execute and deliver any instrument that such Mortgagee may reasonably request to
evidence such attornment provided such document contains reasonably satisfactory non-disturbance
provisions to allow Tenant to remain in occupancy pursuant to this Lease and exercise all of its
other rights under this Lease as long as no Event of Default exists. The form of instrument
attached as Exhibit 10.01 shall be deemed acceptable to Tenant. If requested by any such
Mortgagee, Tenant further agrees to enter into a new lease for the balance of the term of this
Lease (and otherwise upon the same terms and conditions of this Lease) in the event of a judicial
or non-judicial foreclosure of a mortgage granted to any Mortgagee. Landlord will reimburse Tenant
for all reasonable third party attorneys’ fees that Tenant incurs to review such agreement pursuant
to the preceding sentence.

     Upon such attornment, the Mortgagee shall not be: (i) liable in any way to the Tenant for any
act or omission, neglect or default on the part of Landlord under this Lease except that the
Mortgagee shall cure any continuing failure to perform maintenance or repair work (but shall not be
liable for any damages arising prior to the attornment) and complete the Landlord Work in
accordance with the Lease (ii) responsible for any monies owing by or on deposit with Landlord to
the credit of Tenant unless received by the Mortgagee, but it shall be liable for payment of any
unpaid portion of the Finish Work Allowance being funded by the loan and to the extent not
previously advanced by such Mortgagee; (iii) subject to any credit, counterclaim or setoff which
theretofore accrued to Tenant against Landlord; (iv) bound by any modification of this Lease
subsequent to such mortgage or by any previous prepayment of regularly scheduled monthly
installments of Base Rent for more than (1) month, which was not approved in writing by the
Mortgagee; (v) liable to the Tenant beyond the Mortgagee’s interest in the Property and the rents,
income, receipts, revenues, issues and profits issuing from such Property; or (vi) liable for any
portion of a security deposit not actually received by the Mortgagee.

               (c) The covenant and agreement contained in this Lease with respect to the rights, powers and
benefits of any such Mortgagee constitute a continuing offer to any person, corporation or other
entity, which by accepting or requiring an assignment of this Lease or by entry of foreclosure
assumes the obligations set forth in this Article 10 with respect to such Mortgagee.

               (d) No assignment of this Lease and no agreement to make or accept any surrender, termination
or cancellation of this Lease and no agreement to modify so as to reduce the Rent, change the term,
or otherwise materially change the rights of the Landlord under this Lease, or to relieve the
Tenant of any obligations or liability under this Lease, shall be valid unless consented to in
writing by the Landlord’s Mortgagees, if any, to the extent that such consent is required pursuant
to the terms of the applicable mortgage or ground lease.

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               (e) The Tenant agrees, within ten (10) business days following the request of the Landlord, to
execute and deliver from time to time any agreement, in recordable form, which may reasonably be
deemed necessary to implement the provisions of this Section 10.01, including, without limitation,
the form of agreement attached as Exhibit 10.01. Landlord will reimburse Tenant for all
reasonable third party attorneys’ fees that Tenant incurs to review such agreement under this
subsection (e) if the form provided by Landlord is not substantially similar to Exhibit
10.01, provided that Landlord shall have no obligation to reimburse Tenant for any amount in
excess of $4,000 in any one instance (such amount to be increased, but never decreased, annually in
proportion to any increase in the CPI).

               (f) Landlord agrees that any subordination of this Lease to any mortgage now or hereafter
encumbering the Premises shall be conditioned upon Landlord delivering to Tenant a written,
recordable Subordination, Non-Disturbance and Attornment Agreement from the ground lessor or
mortgagee seeking to have this Lease subordinated to its interest substantially in the form
attached as Exhibit 10.01 or in such other customary form as is required by Landlord’s
mortgagee. Landlord shall provide Tenant with a non-disturbance agreement from Landlord’s current
first mortgage lender, Bank of America, N.A., simultaneously with the execution and delivery of
this Lease.

     Section 10.02. Estoppel Certificates. Each party agrees to furnish to the other,
within ten (10) business days after request therefor (or, with respect to Tenant, if requested of
Tenant by any Mortgagee) from time to time, a written statement setting forth the following
information:

               (a) Whether and when Tenant accepted possession of the Premises, and the commencement and
expiration dates of the term of this Lease,

               (b) The applicable Rent then being paid, including all Additional Rent based upon the
Additional Rent most recently established;

               (c) That, if true, the Lease is current and the party providing the statement is not aware of
any uncured breach of this Lease or specifying any breach;

               (d) That, if true, the party providing the statement is not aware of any current claims or
offsets against the other party, or specifically listing any such claims;

               (e) The date through which Base Rent and Additional Rent has then been paid;

               (f) Whether Tenant then meets the Financial Test;

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               (g) Such other information relevant to the Lease as the requesting party may reasonably
request;

               (h) A statement that any prospective Mortgagee and/or purchaser may rely on all such
information.

Without limiting the generality of the foregoing, Tenant has approved the statement form attached
as Exhibit 10.02.

     Section 10.03. Notices to Mortgagees. After receiving notice from any person, firm or
other entity that it holds a mortgage which includes the Premises as part of the mortgaged
premises, or that it is the ground lessor under a lease with the Landlord, as ground Tenant, which
includes the Premises as a part of the mortgaged premises, no notice from the Tenant to the
Landlord shall be effective against such Mortgagee unless and until a copy of the same is given to
such Mortgagee, and the curing of any of the Landlord’s defaults by such Mortgagee shall be treated
as performance by the Landlord. Accordingly, no act or failure to act on the part of the Landlord
which would entitle the Tenant under the terms of this Lease, or by law, to be relieved of the
Tenant’s obligations hereunder, to exercise any right of self-help or to terminate this Lease,
shall result in a release or termination of such obligations or a termination of this Lease unless
(i) the Tenant shall have first given written notice to such Mortgagee of the Landlord’s act or
failure to act which could or would give basis for the Tenant’s rights; and (ii) such Mortgagee,
after receipt of such notice, has failed or refused to correct or cure the condition complained of
within the applicable cure period afforded Landlord under this Lease or such longer period of time
as may be reasonably required by Mortgagee to cure such default with due diligence (including such
time as may be necessary for Mortgagee to obtain possession or title to the Property, if required
to cure the default, but in no event shall such longer period of time exceed, in the aggregate, 180
days).

     Section 10.04. Assignment of Rents. With reference to any assignment by the Landlord
of the Landlord’s interest in this Lease, or the rents payable hereunder, conditional in nature or
otherwise, which assignment is made to the a Mortgagee, the Tenant agrees:

               (a) That the execution thereof by the Landlord, and the acceptance thereof by the Mortgagee,
shall never be treated as an assumption by such Mortgagee of any of the obligations of the Landlord
hereunder, unless such Mortgagee shall, by notice sent to the Tenant, specifically make such
election; and

               (b) That, except as aforesaid, such Mortgagee shall be treated as having assumed the
Landlord’s obligations hereunder only upon foreclosure of such Mortgagee’s mortgage or the taking
of possession of the Property, or, in the case of a ground lessor, the termination of the ground
lease.

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Article 11.

Fire, Casualty and Eminent Domain

     Section 11.01. Rights to Terminate the Lease. The Landlord, at its sole option, may
elect to terminate this Lease, provided that Landlord is then also terminating the lease of any
other tenant that is similarly affected in the Building, if (i) all or substantially all of the
Premises or at least 50 percent of the Building (not including the Premises) is damaged by a
casualty not insured by the coverage required to be carried hereunder (whether or not such
insurance is actually carried), or is taken by eminent domain, (ii) the Building is damaged by an
fire or other casualty (whether or not insured) such that the same cannot, in ordinary course,
reasonably be expected to be restored within 270 days from the time that such restoration work
would commence, or (iii) the Premises or Building is damaged by a fire or other casualty, or is
taken by eminent domain, at a time when no more than 18 months then remain in the term of this
Lease, and the time reasonably estimated by Landlord’s general contractor pursuant to Section
11.01(b), below, to restore the Premises or Building, as applicable, will take longer than 50% of
the then-remaining term of the Lease (unless, within 21 days after receipt of Landlord’s
termination notice, Tenant exercises any then-remaining right to extend the term of this Lease
pursuant to Article 22 hereof). When fire or other unavoidable casualty or taking renders any
portion of the Premises substantially unsuitable for its intended use (including, without
limitation, by causing damage to such portions of the common areas and facilities of the Building
as are necessary to provide reasonably safe access to the Premises and to provide those building
services, such as utilities and HVAC service, that Landlord is required to provide hereunder), a
just and proportionate abatement of rent shall be made for so long as such interference shall
continue, and the Tenant may elect to terminate this Lease if:

               (a) The Landlord fails, within ten (10) days following written notice from Tenant of such
failure, to give written notice sixty (60) days after such casualty of its intention to restore the
Premises (and such portions of the common areas and facilities of the Building as are necessary to
provide reasonably safe access to the Premises and to provide those building services, such as
utilities and HVAC service, that Landlord is required to provide hereunder) or provide alternate
access, if access has been taken or destroyed; or

               (b) If Landlord gives notice of its intention to restore and, in the reasonable estimate of
Landlord’s general contractor, such restoration of the Premises (and such portions of the common
areas and facilities of the Building as are necessary to provide reasonably safe access to the
Premises and to provide those building services, such as utilities and HVAC service, that Landlord
is required to provide hereunder) will take greater than nine (9) months to complete (or, if less
than eighteen (18) months remain in the term of this Lease, greater than one-half of the
then-remaining length of the term), provided that Tenant gives such notice within 30 days after
receiving Landlord’s notice that it intends to restore the Premises; or

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               (c) If Landlord gives notice of its intention to restore and the Landlord fails to restore the
Premises (together with such portions of the common areas and facilities of the Building as are
necessary to provide reasonably safe access to the Premises and to provide those building services,
such as utilities and HVAC service, that Landlord is required to provide hereunder) to a condition
substantially suitable for their intended use within the longer of nine (9) months or such longer
period as Landlord’s general contractor has estimated for restoration pursuant to clause (b),
above, plus a contingency period equal to 10% of such period estimated by the general contractor,
of such fire or other unavoidable casualty, or taking; provided however, that (x) in the event
Landlord has diligently commenced repairs to the damaged property and such repair takes more than
such period to complete due to causes beyond Landlord’s reasonable control, Landlord shall have the
right to complete such repairs within a reasonable time period thereafter (the “Additional
Time”) but in no event shall such Additional Time be longer than the shorter of (i) ninety (90
) days; or (ii) the length of such delays beyond Landlord’s reasonable control and (y) if Landlord
completes such restoration within 30 days following receipt of Tenant’s notice of termination, then
such notice of termination shall be deemed null and void and of no further force and effect.

     The Landlord reserves, and the Tenant grants to the Landlord, all rights which the Tenant may
have for damages or injury to the Premises for any taking by eminent domain, except for damages
specifically awarded on account of the Tenant’s trade fixtures, property or equipment, and moving
expenses.

     Section 11.02. Restoration Obligations. If the Lease has not terminated pursuant to
Section 11.01, then, following any casualty or taking by eminent domain, Landlord shall proceed
with diligence, subject to then applicable statutes, building codes, zoning ordinances and
regulations of any governmental authority, and the receipt of insurance proceeds, to repair or
cause to be repaired such damage (excluding any Tenant Work and Finish Work). All repairs to and
replacements of Tenant’s Tenant Work, Finish Work, trade fixtures, equipment and personal property
shall be made by and at the expense of Tenant.

Article 12.

Indemnification

     Section 12.01. General Indemnity. Subject to the waiver of claims set forth in
Section  4.05, except to the extent arising from a breach of this Lease by Landlord or the
negligent acts or willful misconduct of Landlord or Landlord’s agents, contractors or employees,
Tenant shall defend, indemnify and hold harmless Landlord, Landlord’s lenders, Landlord’s managing
agent, The Prudential Life Insurance Company of America, the association of unit owners of the
Reservoir Woods Primary Condominium and their respective partners, members, managers, officers,
directors, and employees (the “Indemnitees”) from and against any and all claims, demands,
liabilities, damages, judgments, orders, decrees, actions, proceedings, fines, penalties, costs and
expenses, including without limitation, court costs and attorneys’ fees, (x) arising from or
relating to any third party claim for loss of life, or damage or injury to a person or property
(i) occurring in the Premises or arising out of the use of the common areas of the Property by
Tenant, or

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its agents, employees, or contractors or anyone claiming by or through Tenant, (ii) caused by
any negligent act or omission or violation of this Lease by Tenant, or its agents, employees, or
contractors or anyone claiming by or through Tenant, or (y) arising out the exercise of Tenant’s
rights under Section 14.07(b) (including without limitation any claim by another tenant in
the Building that such exercise resulted in a default under its lease).

     Subject to the waiver of claims set forth in Section 4.05, except to the extent arising from a
breach of this Lease by Tenant or the negligent acts or willful misconduct of Tenant or Tenant’s
agents, contractors or employees, Landlord shall defend, indemnify and hold harmless Tenant from
and against any and all claims, demands, liabilities, damages, judgments, orders, decrees, actions,
proceedings, fines, penalties, costs and expenses, including without limitation, court costs and
attorneys’ fees, arising from or relating to any third party claim for loss of life, or damage or
injury to a person or property caused by any negligent act or omission or violation of this Lease
by Landlord, its agents, employees, or contractors.

     Section 12.02. Defense Obligations. In case any action or proceeding is brought
against either party by reason of any such occurrence, the party required to provide
indemnification, upon written notice from the party entitled to indemnification, will, at the sole
cost and expense of the party required to provide indemnification, resist and defend such action or
proceeding or cause the same to be resisted and defended, by counsel designated by the party
required to provide indemnification and approved in writing by the party to be defended, which
approval shall not be unreasonably withheld.

Article 13.

Mortgages, Assignments and Subleases by Tenant

     Section 13.01. Right to Transfer.

               (a) Tenant’s interest in this Lease may not be mortgaged, encumbered, assigned or otherwise
transferred, or made the subject of any license or other privilege, by Tenant or by operation of
law or otherwise, and the Premises may not be sublet, as a whole or in part, (any of the foregoing
events, a “Transfer”) without in each case having obtained the prior written consent of
Landlord, and the execution and delivery to Landlord by the assignee or transferee (in either case,
a “Transferee”) of a good and sufficient instrument whereby such Transferee assumes (with
respect to any sublease, to the extent of the subtenants’ obligations under the applicable
sublease) all obligations of Tenant under this Lease. The provisions of this Article 13 shall
apply to a transfer (by one or more Transfers) of a controlling portion of or interest in the stock
or partnership or membership interests or other evidences of equity interests of Tenant or sale of
all or substantially all of the assets of Tenant as if such Transfer were an assignment of this
Lease; provided, that, so long as equity interests in Tenant are traded on a nationally recognized
public stock exchange, the transfer of equity

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interests in Tenant on such public stock exchange shall not be deemed an assignment within the
meaning of this Article. Subject to the provisions of this Article 13, Landlord shall not
unreasonably withhold, condition or delay its consent to any sublet of all or any portion of the
Premises or any assignment of Tenant’s interest in this Lease. It shall be reasonable for Landlord
to withhold its consent with respect to any proposed Transfer if the Transferee is not sufficiently
creditworthy to meet its obligations under such assignment or sublease, as demonstrated by audited
financial statements or equivalent evidence. It shall be reasonable for Landlord to deny its
consent to any Transfer to any of the following so long as Landlord has competitive space in the
Building (e.g. similar type and size of space, offered for a similar term) available for lease
prior to the earlier to occur of the date that is 24 months following the initial Commencement Date
to occur or the date that Building is first fully leased to unrelated third parties: (i) a tenant
at the Property or in the office park known as Reservoir Woods; (ii) any party with whom Landlord
has negotiated in the previous six (6) months with respect to space in the Building; (iii) any
affiliates controlled by, controlling, or under common control with any tenant or party described
in clauses (i) and (ii) hereof and it shall be reasonable for Landlord to withhold its consent to
any Transfer in violation of the provisions of this sentence. It shall be reasonable for Landlord
to withhold its consent to a Transfer to any party which would be of such type, character or
condition as to be inappropriate, in Landlord’s reasonable judgment, as a tenant for a first class
suburban office building.

     Nothing herein contained shall be construed as requiring Tenant to obtain any consent on the
part of Landlord (i) as a condition to or any assignment resulting from any merger, consolidation,
or sale of all or substantially all of the assets of Tenant, or acquisition of all or substantially
all of the issued and outstanding capital stock of Tenant or (ii) as a condition to any assignment
or sublease to any affiliates controlled by, controlling, or under common control with Tenant;
provided that (a) Tenant gives Landlord at least twenty (20) days prior written notice of such
event or Transfer (except that no prior notice need be given with respect to any Transfer referred
to in clause (b) below to the extent that such notice is prohibited by law or by confidentiality
agreement, in which case Tenant shall provide Landlord with notice of such Transfer within ten (10)
business days following such Transfer) with evidence reasonably satisfactory to Landlord that the
conditions of this paragraph have been satisfied, (b) in the case of an assignment, merger,
consolidation or asset sale the Transferee shall be at least as creditworthy as the then Tenant as
of the date that is three months prior to such Transfer, as demonstrated by audited financial
statements or equivalent evidence (the determination of creditworthiness shall take into account
all of the considerations which an institutional investor in real estate would consider in
evaluating the credit of a proposed tenant), (c) the Transferees comply with the provisions of this
Lease, and (d) with respect to a Transfer to any affiliate of Tenant pursuant to clause (ii),
above, the provisions of this Article 13 shall apply to such Transfer if, as and when such
affiliate ceases to be an affiliate of Tenant. Any Transferee referred to in the immediately
preceding sentence is referred to herein as a “Permitted Transferee”. Any such Permitted
Transferee, however, shall be subject to the terms and conditions set forth in Section 13.02 below.
For purposes of this Lease, control shall mean possession of more than 50 percent ownership of the
shares of beneficial interest of the entity in question together with the power to control and
manage the affairs thereof either directly or by election of directors and/or officers.

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     In connection with any request by Tenant for any consent to Transfer, Tenant shall provide
Landlord with all relevant information requested by Landlord concerning the proposed Transferee’s
financial responsibility, credit worthiness and business experience to enable Landlord to make an
informed decision. Tenant shall reimburse Landlord promptly for all reasonable out-of-pocket
expenses incurred by Landlord including reasonable attorneys’ fees in connection with the review of
Tenant’s request for consent to any Transfer.

     Any purported Transfer under this Article 13 without Landlord’s prior written consent or prior
notice (as applicable) to the extent such consent or notice is required, shall be void and of no
effect. No acceptance of Rent by Landlord from or recognition in any way of the occupancy of the
Premises by a Transferee shall be deemed consent to such Transfer. Without limiting Landlord’s
right to withhold its consent to any Transfer by Tenant, and regardless of whether Landlord shall
have consented to any such Transfer, neither Tenant nor any other person having an interest in the
possession, use, or occupancy of any portion of the Premises shall enter into any lease, sublease,
license, concession, assignment, or other transfer or agreement for possession, use, or occupancy
of all or any portion of the Premises which provides for rental or other payment for such use,
occupancy, or utilization based, in whole or in part, on the net income or profits derived by any
person or entity from the space so leased, used, or occupied, and any such purported lease,
sublease, license, concession, assignment, or other transfer or agreement shall be absolutely void
and ineffective as a conveyance of any right or interest in the Premises. Furthermore, Tenant
agrees that in the event Landlord determines, in its sole discretion, that there is any risk that
all or part of any amount payable under or in connection with any Transfer shall cause any amounts
to be received by Landlord to fail to qualify as “rents from real property” within the meaning of
Code Sections 512(b)(3) and 856(d) and the Treasury Regulations thereunder, Tenant shall amend or
modify the terms of such Transfer.

               (b) In the event Tenant Transfers the Premises or any part thereof for consideration in excess
of the obligations of Tenant to Landlord hereunder, other than with respect to a Permitted
Transferee, Tenant shall from time to time within fifteen (15) days of receipt pay over to Landlord
an amount equal to fifty percent (50%) of the excess, if any, of (1) any consideration, rent, or
other amounts received by Tenant from such Transferee, over (2) the sum of the rents and other
expenses payable by Tenant to Landlord hereunder, after such excess is applied to reimburse Tenant
for the actual and reasonable third-party costs for legal fees, brokerage costs, leasehold
improvements, free rent or other out-of-pocket rent concession payments incurred by Tenant in
procuring the Transfer, and the amount of any unamortized costs incurred by Tenant for Excess
Finish Work pursuant to Exhibit 7.02. (Tenant’s reimbursement for the costs of the Excess
Finish Work shall be in monthly amounts to amortize such costs on a straight-line basis without
interest over the term of the Transfer in question). Within ten (10) days after request by
Landlord from time to time, Tenant shall provide Landlord with an itemized statement of all such
costs, together with reasonable third party back-up documentation for the same. Without limiting
the generality of the first sentence of this subparagraph, any lump-sum payment or series of
payments actually or reasonably allocated to Tenant’s interest in the Premises (including the
purchase or use of so-called leasehold improvements), as opposed to other assets of Tenant, on
account of any Transfer shall be deemed to be in excess of rent and other charges to the extent
such payments, if amortized at a market interest rate over the period to which such charges relate,
exceeds rent or

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other charges allocable to the period to which such payments relate (i.e. if it is a single
lump sum payment for an assignment of the entire lease, the period to which they would relate is
the entire then-remaining term). In the event of any dispute regarding the allocation referenced
in the immediately preceding sentence, either party may submit such matter to arbitration pursuant
to the provisions of the last paragraph of Section 14.07(b) of this Lease.

     Section 13.02. Tenant Remains Bound. No Transfer of any interest in this Lease, and
no execution and delivery of any instrument of assumption pursuant to Section 13.01 hereof, shall
in any way affect or reduce any of the obligations of Tenant under this Lease, but this Lease and
all of the obligations of Tenant under this Lease shall continue in full force and effect as the
obligations of a principal (and not as the obligations of a guarantor or surety). From and after
any such Transfer, the obligations of each such Transferee and of the original Tenant named as such
in this Lease to fulfill all of the obligations of Tenant under this Lease shall be joint and
several (but, with respect to any sublease, solely with respect to the obligations assumed by the
subtenant thereunder). Each violation of any of the covenants, agreements, terms or conditions of
this Lease, whether by act or omission, by any of Tenant’s permitted encumbrances, assignees,
employees, transferees, licensees, grantees of a privilege, sub-tenants or occupancy, shall
constitute a violation thereof by Tenant. The consent by Landlord to any Transfer shall not
relieve Tenant or any Transferee from the obligation of obtaining the express consent of Landlord
to any modification of such Transfer or a further Transfer by Tenant or such transferee.

Article 14.

Default

     Section 14.01. Events of Default. It shall be an “Event of Default” in the
event that:

               (a) the Tenant shall default in the due and punctual payment of any installment of Base Rent,
or any part hereof, when and as the same shall become due and payable and such default shall
continue for more than five (5) business days after notice that such payment is due;

               (b) the Tenant shall default in the payment of any Additional Rent, or any part thereof, when
and as the same shall become due and payable, and such default shall continue for a period of ten
(10) days, with respect to Tenant’s regular monthly payments of Operating Expenses and Taxes, and
(20) days otherwise, after notice that such payment is due; or

               (c) the Tenant shall default in the observance or performance of any of the Tenant’s
covenants, agreements or obligations under Sections 10.01 and 10.02 of the Lease within the time
periods set forth therein or default in the observance or performance of any of the Tenant’s
covenants, agreements or obligations under Section 20.06;

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               (d) the Tenant shall default in the observance or performance of any of the Tenant’s
covenants, agreements or obligations hereunder, other than those referred to in the foregoing
clauses (a) — (c), and such default shall not be corrected within thirty (30) days after written
notice; provided, however, if Tenant promptly commenced to cure the default and diligently pursued
the cure, but such default was not capable of being cured by Tenant within the said thirty (30) day
period and Tenant so notified Landlord promptly (but in any event within thirty (30) days after
notice of such default was given) together with an estimate of the reasonable time required for
such cure, Tenant shall be allowed such longer period, but in no event longer than 180 days; or

               (e) the Tenant shall file a voluntary petition in bankruptcy or shall be adjudicated bankrupt
or insolvent, shall file any petition or answer seeking any reorganization, arrangement,
composition, dissolution or similar relief under any present or future federal, state or other
statute, law or regulation relating to bankruptcy, insolvency or other relief for debtors, or shall
seek, or consent, or acquiesce in the appointment of any trustee, receiver or liquidator of Tenant
of all or any substantial part of their respective properties, or of the Premises, or shall make
any general assignment for the benefit of creditors; or

               (f) a petition is filed against Tenant seeking any reorganization, arrangement, composition,
dissolution or similar relief under any present or future federal, state or other statute, law or
regulation relating to bankruptcy, insolvency or other relief for debtors, and such petition is not
dismissed within sixty (60) days;

then, unless and until Landlord accepts a full cure of the default giving rise to the Event of
Default, Landlord shall have the right thereafter to re-enter and take complete possession of the
Premises, to declare this Lease terminated by written notice to Tenant and to remove the Tenant’s
effects without prejudice to any remedies which might be otherwise used for arrears of Rent or
other Event of Default. Any written notice of termination by Landlord may, at Landlord’s express
election, serve as any statutory demand or notice that is a prerequisite to Landlord’s commencement
of eviction proceedings against Tenant, and may, at Landlord’s express election, be included in any
notice of default (provided, however, that any such notice included in a notice of default shall
not be effective unless and until the expiration of applicable notice and cure periods).

     The Tenant shall indemnify the Landlord against all loss of Rent and other payments which the
Landlord may incur by reason of such termination during the residue of the term. Without limiting
the generality of the foregoing, Landlord may elect by written notice to Tenant following such
termination to be indemnified for loss of Rent by a lump sum payment representing the present value
of the amount of Base Rent and Additional Rent which would have been paid in accordance with this
Lease for the remainder of the term minus the present value of the aggregate fair market rent and
Additional Rent for the Premises on an “as-is” basis during such time period, estimated as of the
date of termination, and taking into account reasonable projections of vacancy and time required to
re-let the Premises. (For purposes of the lump sum calculation, Additional Rent for the last
12 months prior to termination shall be deemed to increase for each year thereafter by the average
annual increase during the immediately preceding 5 years in the Consumer Price Index - All Urban
Consumers for the Boston Metropolitan area published by the U.S. Department of Labor or a
comparable

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index reasonably selected by Landlord. The Federal Reserve discount rate, or equivalent, plus
2% shall be used in calculating present values.) In the absence of such election, Tenant shall
indemnify Landlord for the loss of Rent by a payment at the end of each month which would have been
included in the term equal to the difference between the Base Rent and Additional Rent which would
have been paid in accordance with this Lease and the Rent actually derived from the Premises by
Landlord for such month.

     In addition to the payment(s) due under the prior paragraph, Tenant shall reimburse Landlord
for all reasonable expenses arising out of the termination, including without limitation, all costs
incurred by Landlord in attempting to re-let the Premises or parts thereof such as advertising,
brokerage commissions, tenant fit-up costs, and legal expenses. The reimbursement from Tenant
shall be due and payable immediately from time to time upon notice from Landlord of the expense so
incurred. Landlord shall use reasonable efforts re-let the Premises in the event the Lease is
terminated pursuant to this Article 14, however, Landlord’s obligation shall be subject to the
reasonable requirements of Landlord to lease other available space for comparable use prior to
reletting the Premises and to lease to high quality tenants in a harmonious manner with an
appropriate mix of uses, tenants, floor areas and terms of tenancies. The provisions of this
Section 14.01, and Tenant’s obligations to Landlord hereunder, shall survive the termination of
this Lease.

     Section 14.02. Landlord’s Right to Cure. If an Event of Default occurs or Landlord
reasonably determines that an emergency posing imminent threat of injury or damage to persons or
property exists, the Landlord, without being under any obligation to do so and without thereby
waiving its rights with regard to any Event of Default, may, after prior written notice to Tenant
(prior written notice shall not be required if not practical in the case of an emergency posing
imminent threat of injury or damage to persons or property ) remedy the default giving rise to the
Event of Default , or the imminent threat, for the account and at the expense of the Tenant. If
the Landlord makes any reasonable expenditures or incurs any reasonable obligations for the payment
of money in connection therewith, including but not limited to reasonable attorney’s fees in
instituting, prosecuting or defending any action or proceeding, such sums paid or obligation
incurred and costs, shall be paid upon demand to the Landlord by the Tenant as Additional Rent and,
if not paid within five (5) business days following notice that such amount is past due (provided
that no such notice shall be required following the first two such notices in any 12 month period)
with interest at the rate of eighteen (18%) percent per annum for the purposes of late payments of
Base Rent or regular monthly payments of Operating Expenses and Taxes, and otherwise at the Prime
Rate plus six percent (6%) per annum, (the applicable such rate, the “Default Rate”)
calculated as of the date such payments were due.

     Section 14.03. No Waiver. No failure by either party to insist upon strict
performance of any covenant, agreement, term or condition of this Lease, or to exercise any right
or remedy consequent upon breach thereof, and no acceptance by Landlord of full or partial Rent
during the continuance of any breach, shall constitute a waiver of any such breach or of any
covenant, agreement, term or condition. No covenant, agreement, term or condition of this Lease to
be performed or complied with by either party, and no breach thereof, shall be waived, altered or
modified except by written instrument executed by the other party. No waiver of any breach shall

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affect or alter this Lease, but each and every covenant, agreement, term and condition of this
Lease shall continue in full force and effect with respect to any other then existing or subsequent
breach thereof.

     Section 14.04. Late Payments. In the event (i) any payment of Rent is not paid within
five (5) business days of the due date, or (ii) a check received by Landlord from Tenant shall be
dishonored, then because actual damages for a late payment or for a dishonored check are extremely
difficult to fix or ascertain, but recognizing that damage and injury result therefrom, Tenant
agrees to pay 5% of the amount due in (i)  as liquidated damages for each late payment and 2.5% of
the amount due in (ii)  as liquidated damages for each time a check is dishonored. Notwithstanding
the foregoing, no payment shall be due under the foregoing sentence for the first late payment of
Rent in any twelve (12) month period if such Rent payment is made within five (5) business days
after written notice from Landlord to Tenant. Furthermore, if any payment of Rent shall not be
paid when due, the same shall bear interest, from the date when the same was due until the date
paid, at the Default Rate; provided, however, that no interest shall be due with respect to late
payments of Rent on the first occasion in any 12 month period unless Tenant fails to make such
payment within five (5) business days after Landlord gives Tenant notice of such delinquency. (The
grace periods herein provided are strictly related to the liquidated damages for, and interest on,
a late payment and shall in no way modify or stay Tenant’s obligation to pay Rent when it is due,
nor shall the same preclude Landlord from pursuing its remedies under this Article 14, or as
otherwise allowed by law.)

     Section 14.05. Remedies Cumulative. Each right and remedy of Landlord provided for in
this Lease shall be cumulative and concurrent and shall be in addition to every other right or
remedy provided for in this Lease now or hereafter existing at law or in equity or by statute or
otherwise, and the exercise or beginning of the exercise by Landlord of any one or more of the
rights or remedies provided for in this Lease now or hereafter existing at law or in equity or by
statute or otherwise shall not preclude the simultaneous exercise by Landlord of any or all other
rights or remedies provided for in this Lease or now or hereafter existing at law or in equity or
by statute or otherwise.

     Section 14.06. Landlord’s Obligation to Make Payments. Tenant shall not be entitled
to offset against Rent any payments due from Landlord to Tenant except as expressly set forth
herein.

     Section 14.07. Landlord Defaults.

               (a) Landlord shall in no event be in default in the performance of any of Landlord’s
obligations under the terms of this Lease unless and until Landlord shall have failed to perform
such obligation within thirty (30) days after notice by Tenant to Landlord (“Tenant Default
Notice”) specifying the manner in which Landlord has failed to perform any such obligations
(provided, however, if Landlord promptly commences to cure the default and diligently pursues the
cure, but such default is not capable of being cured by Landlord within the said thirty (30) day
period and Landlord so notifies Tenant promptly (but in any event within thirty (30) days after
such Tenant Default Notice is given) together with an estimate of the reasonable time required for
such cure, Landlord shall

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be allowed such longer period, , but in no event longer than 180 days). The provisions of
this Section 14.07 shall not apply to Landlord’s obligations to complete the Landlord Work, the
sole and exclusive remedies for which are set forth in Section 1.03 of this Lease.

               (b) Tenant’s Self-Help Right. If Landlord is in default in the performance of any of
its obligations hereunder beyond applicable notice and cure periods, then Tenant shall have the
right to remedy such default on Landlord’s behalf (provided that Tenant uses reasonable efforts to
avoid violating or rendering void any warranties maintained by Landlord) after ten (10) business
days prior notice to Landlord, in which event Landlord shall reimburse Tenant within 30 days after
invoice for all reasonable costs and expenses incurred by Tenant in connection therewith to the
extent in excess of Tenant’s Pro Rata Share of the Operating Expenses that Tenant would have been
obligated to pay had Landlord performed such obligations within applicable notice and cure periods,
together with interest at the Default Rate, and if not so paid then Tenant shall have the right to
recover the same by an abatement of Base Rent, provided that such abatement shall cease at such
time as and to the extent that payment of the full amount then due Tenant hereunder is tendered to
Tenant. Notwithstanding the foregoing, if Landlord disputes Tenant’s right to abate Base Rent, or
the amount of the abatement, such dispute shall be resolved in an arbitration proceeding pursuant
to the immediately following paragraph prior to any abatement of disputed amounts by Tenant and if
the amount of the abatement is more than 20% of the aggregate amount of Base Rent due in any month,
then the amount abated in any one month shall not exceed 20% of the Base Rent and the excess amount
of the abatement shall be carried forward with interest at the Default Rate. Tenant’s self-help
rights under this paragraph shall be exercised by Tenant only (i) with respect to conditions
actually existing within the Premises or, in the event of an emergency, in common areas of the
Building, and (ii) with respect to conditions that materially affect Tenant’s ability to use and
enjoy the Premises and to conduct Tenant’s operations therein. Tenant is not precluded from
entering into other tenant spaces in the exercise of the foregoing self-help rights to the extent
reasonably necessary to access common areas of the Building; provided, however, that (x) any such
entry by Tenant’s shall be at its own risk and expense and (y) Tenant obtains, in advance, an
agreement from the other tenant allowing such entry. The provisions of this paragraph may not be
exercised by any subtenants of Tenant.

     Any arbitration decision under this paragraph shall be enforceable in accordance with
applicable law in any court of proper jurisdiction. Within fifteen (15) days after Landlord
requests arbitration by notice to Tenant, the parties shall direct the Boston office of the AAA to
appoint an arbitrator who shall have a minimum of ten (10) years experience in commercial real
estate disputes and who shall not be affiliated with either Landlord or Tenant. Both Landlord and
Tenant shall have the opportunity to present evidence and outside consultants to the arbitrator.
The arbitration shall be conducted in accordance with the Commercial Arbitration Rules of the AAA
insofar as such rules are not inconsistent with the provisions of this Lease (in which case the
provisions of this Lease shall govern). The cost of the arbitration (exclusive of each party’s
witness and attorneys’ fees, which shall be paid by such party) shall be borne equally by the
parties. The decision of the arbitrator(s) shall be final and binding on the parties. The parties
shall comply with any orders of the arbitrator(s) establishing deadlines for any such proceeding.

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Article 15.

Surrender

     Section 15.01. Obligation to Surrender. Tenant shall, upon any expiration or earlier
termination of the term of this Lease, remove all of Tenant’s Property from the Premises unless
otherwise approved by Landlord in writing. Tenant shall peaceably vacate and surrender to the
Landlord the Premises and deliver all keys, locks thereto, and subject to Section 8.01 all
alterations and additions made to or upon the Premises, in the same condition as they were at the
commencement of the term, or as they were put in during the term hereof, reasonable wear and tear
and, to the extent Landlord is required to restore the same, damage by fire or other casualty or
taking or condemnation by public authority excepted. In the event of the Tenant’s failure to
remove any of Tenant’s Property from the Premises, Landlord is hereby authorized, without liability
to Tenant for loss or damage thereto, and at the sole risk of Tenant, to remove and store any of
the property at Tenant’s expense, or to retain same under Landlord’s control or to sell at public
or private sale, after thirty (30) days notice to Tenant at its address last known to Landlord, any
or all of the property not so removed and to apply the net proceeds of such sale to the payment of
any sum due hereunder, or to destroy such property.

     Section 15.02. Holdover Remedies. If Tenant (or anyone claiming by, through, or under
Tenant) shall remain in possession of the Premises or any part thereof after the expiration or
earlier termination of this Lease with respect thereto without any agreement in writing executed
with Landlord, Tenant shall be deemed a tenant at sufferance. After the expiration or earlier
termination of the term of this Lease, Tenant shall pay Base Rent at the higher of (x) 150% of the
Base Rent in effect immediately preceding such expiration or termination or, (y) 150% of the
then-market rate for the Premises, and, in either case, with all Additional Rent payable and
covenants of Tenant in force as otherwise herein provided, and, commencing on the date that is 45
days after the expiration or earlier termination of this Lease, Tenant shall be liable to Landlord
for all damages arising from such failure to surrender and vacate the Premises, including damages
arising from the loss of a replacement lease transaction. Notwithstanding the forgoing to the
contrary, clause (y) of this paragraph, above, shall not apply in the event that the Lease
terminates prior to its scheduled expiration on account of the exercise of termination rights by
either party pursuant to Article 11 or Tenant pursuant to Section 7.06.

     Section 15.03. Decommissioning. Prior to the expiration of this Lease (or within 30
days after any earlier termination), Tenant shall clean and otherwise decommission all interior
surfaces (including floors, walls, ceilings, and counters), process piping, process supply lines,
process waste lines and process plumbing in the Premises, and all exhaust or other ductwork in the
Premises, in each case which has carried or released or been exposed to any Hazardous Materials
(other than ordinary and customary office supplies and cleaning fluids) from the operations of
Tenant or any person claiming by or through Tenant, and shall otherwise clean the Premises so that:

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               (a) the Hazardous Materials from Tenant (or any person claiming by or through Tenant)
operations, to the extent, if any, existing prior to such decommissioning, have been removed as
necessary so that the interior surfaces (including floors, walls, ceilings, and counters), process
piping, process supply lines, process waste lines and process plumbing, and all such exhaust or
other ductwork, may be reused by a subsequent tenant or disposed of in compliance with applicable
Environmental Laws without taking any special precautions for Hazardous Materials, without
incurring special costs or undertaking special procedures for demolition, disposal, investigation,
assessment, cleaning or removal of Hazardous Materials and without incurring regulatory compliance
requirements or giving notice in connection with Hazardous Materials; and

               (b) the Premises may be reoccupied for office, laboratory or research and development use,
demolished or renovated without taking any special precautions for Hazardous Materials, without
incurring special costs or undertaking special procedures for disposal, investigation, assessment,
cleaning or removal of Hazardous Materials and without incurring regulatory requirements or giving
notice in connection with Hazardous Materials.

     Further, for purposes of clauses (a) and (b): (i) materials previously or hereafter generated
from operations shall not be deemed part of the Premises, and (ii) “special costs” or “special
procedures” shall mean costs or procedures, as the case may be, that would not be incurred but for
the nature of the Hazardous Materials as Hazardous Materials instead of non-Hazardous Materials.
Prior to the expiration of this Lease (or within 30 days after any earlier termination), Tenant, at
Tenant’s expense, shall obtain for Landlord a report addressed to Landlord (and, at Tenant’s
election, Tenant) by a reputable licensed environmental engineer that is designated by Tenant and
acceptable to Landlord in Landlord’s reasonable discretion, which report shall be based on the
environmental engineer’s inspection of the Premises and shall confirm that Tenant has complied with
the requirements of this Section 15.03. The report shall include reasonable detail concerning the
clean-up location, the tests run and the analytic results.

     Tenant may, by written request made no earlier than six months prior to the then-scheduled
expiration of the term of this Lease, request that Landlord approve the scope of Tenant’s
decommissioning activities under this Section 15.03 in writing, which approval shall not be
unreasonably withheld, conditioned or delayed.

     Section 15.04. Failure to Decommission. If Tenant fails to perform its obligations
under Section 15.03 within ten (10) days after the expiration of the term of this Lease, without
limiting any other right or remedy, Landlord may, on five (5) business days prior written notice to
Tenant perform such obligations at Tenant’s expense, and Tenant shall promptly reimburse Landlord
upon demand for all out-of-pocket costs and expenses incurred by Landlord in connection with such
work. In addition, any such reimbursement shall include a ten percent (10%) administrative fee
(but in no event less than $1,000) to cover Landlord’s overhead in undertaking such work and, if
the expiration of the term has occurred on account of a Tenant default or if the Landlord has,
prior to the regularly scheduled expiration of the term, previously approved the scope of Tenant’s
decommissioning activities under Section 15.03 in writing, then Tenant shall be deemed to be in
occupancy of the Premises as a holdover occupant subject to Section 15.02 until the

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obligations are fully performed. The reimbursement and administrative fee shall be Additional
Rent. Tenant’s obligations under this Article 15 of this Lease shall survive the termination of
this Lease.

Article 16.

Quiet Enjoyment

     Section 16.01. Covenant of Quiet Enjoyment. Tenant, subject to any ground leases,
deeds of trust and mortgages to which this Lease is from time to time subordinate in accordance
with Article 10, upon paying the Rent and performing and complying with all covenants, agreements,
terms and conditions of this Lease on its part to be performed or complied with, shall not be
prevented by the Landlord, or anyone claiming by, through or under Landlord, from lawfully and
quietly holding, occupying and enjoying the Premises during the term of this Lease, except as
specifically provided for by the terms hereof. This covenant is in lieu of any other so-called
quiet enjoyment covenant, either express or implied.

Article 17.

Acceptance of Surrender

     Section 17.01. Acceptance of Surrender. No surrender to Landlord of this Lease or of
the Premises or any part thereof or of any interest therein by Tenant shall be valid or effective
unless required by the provisions of this Lease or unless agreed to and accepted in writing by
Landlord. No act on the part of any representative or agent of Landlord, and no act on the part of
Landlord other than such a written agreement and acceptance by Landlord, shall constitute or be
deemed an acceptance of any such surrender.

Article 18.

Notices

     Section 18.01. Means of Giving Notice. All notices, demands, requests and other
instruments which may or are required to be given by either party to the other under this Lease
shall be in writing. All notices, demands, requests and other instruments from Landlord to Tenant
shall be deemed to have been properly given if sent by United States certified mail, return receipt
requested, postage prepaid, or if sent by prepaid Federal Express or other similar overnight
delivery service which provides a receipt, addressed to Tenant at the Premises, attn: Kathryn L.
Biberstein, General Counsel (and, until Tenant occupies the Premises, to Tenant at 88 Sidney
Street, Cambridge, Massachusetts, 02139, attn: Kathryn L. Biberstein, General Counsel or at such
other address or addresses as the Tenant from time to time may have designated by written notice to
Landlord, with a copy to Langer & McLaughlin, LLP, 137

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Newbury Street, Suite 700, Boston, Massachusetts 02116, Attn: Doug McLaughlin, Esq. All
notices, demands, requests and other instruments from Tenant to Landlord shall be deemed to have
been properly given if sent by United States certified mail, return receipt requested, postage
prepaid or if sent by prepaid Federal Express or other similar overnight delivery service which
provides a receipt, addressed to Landlord, c/o Davis Marcus Partners, Inc., One Appleton Street,
Boston, Massachusetts 02116, Attn: Jonathan G. Davis, with copies to Marcus Partners, Inc., 75 Park
Plaza, 4th Floor, Boston, Massachusetts 02116, Attn: Paul R. Marcus; The Prudential Insurance
Company of America, c/o Prudential Real Estate Investors, 8 Campus Drive, Parsippany, New Jersey
07054, Attn.: Lynn DeCastro; and Richard D. Rudman, Esq., DLA Piper LLP (US), 33 Arch Street,
Boston, Massachusetts 02110. Any notice shall be deemed to be effective upon receipt by, or
attempted delivery to, the intended recipient. Any notice under this Lease may be given by counsel
to the party giving such notice.

Article 19.

Separability of Provisions

     Section 19.01. Severability. If any term or provision of this Lease or the
application thereof to any person or circumstance shall, to any extent, be invalid or contrary to
applicable law or unenforceable, the remainder of this Lease, and the application of such term or
provision to persons or circumstances other than those as to which it is held invalid or contrary
to applicable law or unenforceable, as the case may be, shall not be affected thereby, and each
term and provision of this Lease shall be legally valid and enforced to the fullest extent
permitted by law.

Article 20.

Miscellaneous

     Section 20.01. Amendments. This Lease may not be modified or amended except by
written agreement duly executed by the parties hereto.

     Section 20.02. Governing Law. This Lease shall be governed by and construed and
enforced in accordance with the laws of the state in which the Property is located.

     Section 20.03. Counterparts. This Lease may be executed in several counterparts, each
of which shall be an original but all of which shall constitute but one and the same instrument.

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     Section 20.04. Successors and Assigns. The covenants and agreements herein contained
shall, subject to the provisions of this Lease, bind and inure to the benefit of Landlord, its
successors and assigns, and Tenant, and Tenant’s permitted successors and assigns, and no
extension, modification or change in the terms of this Lease effected with any successor, assignee
or transferee shall cancel or affect the obligations of the original Tenant hereunder unless agreed
to in writing by Landlord. The term “Landlord” as used herein and throughout the Lease shall mean
only the owner or owners at the time in question of Landlord’s interest in this Lease. Upon any
transfer of such interest, from and after the date of such transfer, Landlord herein named (and in
case of any subsequent transfers the then transferor), shall be relieved of all liability for the
performance of any obligations on the part of the Landlord contained in this Lease except for
defaults by Landlord prior to such transfer or monies owed by Landlord to Tenant and which were not
assigned to and repayment or performance thereof assumed by such transferee, provided that if any
monies are in the hands of Landlord or the then transferor at the time of such transfer, and in
which Tenant has an interest, shall be delivered to the transferee, then Tenant shall look only to
such transferee for the return thereof.

     Section 20.05. Merger Clause. This instrument (including the exhibits) contains the
entire and only agreement between the parties regarding the lease of the Premises, and no oral
statements or representations or prior written matter not contained in this instrument shall have
any force or effect.

     Section 20.06. Notice of Lease. Upon the mutual execution and delivery of this Lease,
and thereafter, at the request of either Landlord or Tenant in connection with any amendment, the
parties shall execute a document in recordable form containing only such information as is
necessary to constitute a Notice of Lease under Massachusetts law. All recording costs for such
notice shall be borne by Tenant. At the expiration or earlier termination of this Lease, Tenant
shall provide Landlord with an executed termination of the Notice of Lease in recordable form,
which obligation shall survive such expiration or earlier termination.

     Section 20.07. No Lease. The submission of this Lease for review or comment shall not
constitute an agreement between Landlord and Tenant until both have signed and delivered copies
thereof.

     Section 20.08. Reimbursements. Whenever Tenant is required to obtain Landlord’s
approval hereunder, Tenant agrees to reimburse Landlord all reasonable out-of-pocket expenses
incurred by Landlord, including reasonable attorney fees in order to review documentation or
otherwise determine whether to give its consent.

     Section 20.09. Financial Statements. If, at any time, Tenant ceases to be a publicly
traded company subject to the reporting requirements of the SEC, then Tenant, within 30 days
following the end of each fiscal quarter occurring during the term shall furnish to Landlord an
accurate, up-to-date financial statement of Tenant showing Tenant’s financial condition for the
immediately preceding fiscal quarter and, with respect to the fourth fiscal quarter, the fiscal
year, such annual statement to be audited if available, together with a certification from Tenant’s
chief financial officer as to whether Tenant then complies with the Financial Test. Tenant shall
also

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use commercially reasonable efforts to provide the foregoing annual financial statements for
any Transferee of more than 33% of the Premises that is not a publicly traded company subject to
the reporting requirements of the SEC. If any such financial statements are not publicly
available, Landlord shall treat the financial statements confidentially, but shall be permitted to
provide them to prospective and current lenders and prospective purchasers.

     Section 20.10. Parking. Landlord agrees that, during the term of this Lease, Tenant
shall have the right (at no additional charge, other than to the extent provided as Operating
Expenses) to use 351 (based on a ratio of 3.5 spaces per 1,000 rentable square feet of the
Premises) non-designated parking spaces as may be reasonably necessary to accommodate officers,
employees, guests, invitees and clients, in connection with the operation of its business following
the initial Commencement Date. Included within the foregoing spaces are 35 (based on a ratio of 1
per 2,800 rentable square feet of the Premises) non-designated parking spaces located in the
parking garage on the lower level of the Building, with direct access to the Building lobby serving
the Premises. The balance of Tenant’s parking spaces shall be located in the areas shown on
Exhibit 20.10, attached. At Landlord’s election and at no cost to Tenant, Landlord may
designate parking spaces for exclusive use by Tenant and other tenants of the Property and may
install signage or implement a pass or sticker system to control parking use, and may employ valet
parking to meet the requirements of this Section. To the extent applicable to Tenant’s use of the
parking spaces, the provisions of the Lease shall apply, including rules and regulations of general
applicability from time to time promulgated by Landlord.

     Section 20.11. Future Development. (a) Landlord reserves all rights as may be
necessary or desirable to construct additional structured parking at the Property in the location
shown on Exhibit 20.11 or, if otherwise permitted under this Section 20.11(a), one or more
additions to the Building. In connection with any such additional development, exterior common
areas and facilities at the Property may be eliminated, altered, or relocated and may also be
utilized to serve the Building addition(s) and other new improvements. The rights set forth above
shall include rights to use portions of the Property (other than the Premises) for the purpose of
temporary construction staging and related activities and to implement valet parking for reserved
and unreserved parking spaces for the purpose of facilitating construction during such activities.
Landlord agrees that, so long as no Event of Default is continuing under this Lease, it shall not
construct any material additions to the Building unless such construction is in accordance with the
exercise of Tenant’s rights pursuant to Article 25 and it shall not construct any additional
structured parking that would inhibit Tenant’s rights pursuant to Article 25 in any material
manner.

     (b) Landlord and its representatives, contractors, agents, employees and licensees shall have
the right during any construction period to enter the Premises to undertake such work; to shore up
the foundations and/or walls of the Premises and other improvements at the Property; to erect
scaffolding and protective barricades around the Premises or in other locations within or adjacent
to the other improvements at the Property; and to do any other act necessary for the safety of the
Premises or other improvements at the Property or the expeditious completion of such construction.
Landlord shall use reasonable efforts not to interfere with the conduct of Tenant’s business and to
minimize the extent and duration of any inconvenience, annoyance or

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disturbance to Tenant resulting from any work pursuant to this Section in or about the
Premises or Property, consistent with accepted construction practice, and so long as Landlord uses
such reasonable efforts Landlord shall not be liable to Tenant for any compensation or reduction of
Rent by reason of inconvenience or annoyance or for loss of business resulting from any act by
Landlord pursuant to this Section.

     (c) In connection with the foregoing or as Landlord may otherwise reasonably determine is
necessary to accommodate the financing or operation of the Building, Landlord may create a
subsidiary condominium or subject the Property to a ground lease. In the event the Building is
submitted to a subsidiary condominium regime, the Property shall be deemed to be the condominium
unit in which the Premises is located and all common areas and facilities serving such unit of the
condominium, and, at the request of either Landlord or Tenant, Exhibit 1.01-2 shall be
amended accordingly. This Lease shall be subject and subordinate to any such ground lease or
condominium (and covenants and easements granted in connection therewith) so long as the same are
not inconsistent in any material respect with Tenant’s rights under this Lease. Tenant agrees to
enter into any instruments reasonably requested by Landlord in connection with the foregoing so
long as the same do not decrease the rights or increase the obligations of Tenant under this Lease,
including a subordination of this Lease to a ground lease or documents creating a subsidiary
condominium at the Property. Tenant agrees not to take any action to oppose any application by
Landlord for any permits, consents or approvals from any governmental authorities for any
redevelopment or additional development of all or any part of the Property, and will use all
commercially reasonable efforts to prevent any of Tenant’s subtenants or assigns (collectively,
“Tenant Responsible Parties”) from doing so. For purposes hereof, action to oppose any
such application shall include, without limitation, communications with any governmental
authorities requesting that any such application be limited or altered. Also for purposes hereof,
commercially reasonable efforts shall include, without limitation, commercially reasonable efforts,
upon receiving notice of any such action to oppose any application on the part of any Tenant
Responsible Parties, to obtain injunctive relief, and, in the case of a subtenant, exercising
remedies against the subtenant under its sublease. Landlord will reimburse Tenant for all
reasonable third party attorneys’ fees that Tenant incurs to review any such documents and
agreements.

     Section 20.12. Signage. So long as the Tenant originally named herein, or any
successor or assign acquiring Tenant’s interest in the Lease in a merger or acquisition of all or
substantially all of Tenant’s business and assets, is the Tenant hereunder, the Premises consist of
at least 80,000 rentable square feet and continues to include the 852 Winter Street entrance and
lobby, and subject to applicable laws, codes and ordinances, Tenant, at Tenant’s cost, may install
the signage described on Exhibit 20.12, attached. Any signage installed by Tenant pursuant
to this paragraph shall be the responsibility of Tenant, and the design of such signage shall be
subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld,
conditioned, or delayed. All signage described in this Section 20.12 shall be consistent in
quality with similar signage in first class office, laboratory, research and development buildings.
Landlord shall cooperate with Tenant, at Tenant’s cost, as is reasonably required for Tenant to
obtain the approvals necessary for all such signage.

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     Section 20.13. Brokers. Landlord and Tenant each represent and warrant that they have
not directly or indirectly dealt with any broker with respect to the leasing of the Premises other
than CB Richard Ellis and Colliers Meredith & Grew (“Brokers”). Each party agrees to
exonerate and save harmless and indemnify the other against any loss, cost, claim or expense
(including reasonable attorney’s fees) resulting from its breach of the forgoing representation and
warranty. Brokers are to be paid by Landlord pursuant to the terms of a separate agreement.

     Section 20.14. Force Majeure. In the event Landlord or Tenant shall be delayed or
hindered in or prevented from the performance of any act (excluding monetary obligations) required
under this Lease to be performed by such party by reason of strikes, lockouts, labor troubles,
inability to procure materials, failure of power, restricted governmental law or regulations,
riots, insurrection, war or other reason of a like nature not the fault of such party, then
performance of such act shall be excused for the period of the delay, and the period for the
performance of any such act shall be extended for a period equivalent to the period of such delay.
Nothing in this Section 20.14 shall excuse Landlord or Tenant’s failure to make payments under this
Lease when due.

     Section 20.15. Limitations on Liability. None of the provisions of this Lease shall
cause Landlord to be liable to Tenant, or anyone claiming through or on behalf of Tenant, for any
special, indirect or consequential damages, including, without limitation, lost profits or
revenues. None of the provisions of this Lease shall cause Tenant to be liable to Landlord, or
anyone claiming through or on behalf of Landlord, for any special, indirect or consequential
damages, including, without limitation, lost profits or revenues, except for a breach of Section
5.02(b)-(c) of this Lease or as otherwise provided in Section 15.02 of this Lease, and provided
that no remedy expressly set forth in this Lease shall be deemed special, indirect or
consequential. In no event shall any individual partner, officer, shareholder, trustee,
beneficiary, director, agent or similar party be liable for the performance of or by Landlord or
Tenant under this Lease or any amendment, modification or agreement with respect to this Lease.
Tenant agrees to look solely to Landlord’s interest in the Property in connection with the
enforcement of Landlord’s obligations in this Lease.

     Section 20.16. Certain Definitions. The expression “the original term” means the
period of years referred to in Article 2. Prior to the exercise by Tenant of any election to
extend the original term, the expression “the term of this Lease” or any equivalent expression
shall mean the original term; after the exercise by Tenant of the aforesaid election or other
extension of the term, the expression “the term of this Lease” or any equivalent expression shall
mean the original term as extended. The expression “attorneys fees” includes reasonable fees of
in-house and external counsel.

     Section 20.17. Prevailing Parties. Landlord shall pay all reasonable attorney’s fees
incurred by Tenant in connection with any legal action concerning an alleged breach of this Lease
to the extent that Tenant is the prevailing party. Tenant shall pay all reasonable attorney’s fees
incurred by Landlord in connection with any legal action concerning an alleged breach of this Lease
to the extent that Landlord is the prevailing party.

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     Section 20.18. Waiver of Trial by Jury. LANDLORD AND TENANT WAIVE TRIAL BY JURY IN
ANY ACTION TO WHICH THEY ARE PARTIES, and further agree that any action arising out of this Lease
(except an action for possession by Landlord, which may be brought in whatever manner or place
provided by law) shall be brought in the Trial Court, Superior Court Department, in the county
where the Premises are located. Tenant expressly submits and consents in advance to such
jurisdiction in any action or proceeding commenced in such court, hereby waiving personal service
of the summons and complaint, or other process or papers issued therein and agreeing that service
of such summons and complaint or other process or papers may be made by registered or certified
mail addressed to Tenant at the address of Tenant set forth in Section 18.01 hereof.

     Section 20.19. Landlord’s Reserved Rights. Landlord reserves the right from time to
time, without unreasonable (except in emergency) interruption of Tenant’s use and access to the
Premises: (i) to make additions to or reconstructions of the Building and to install, use,
maintain, repair, replace and relocate for service to the Premises and other parts of the Building,
or either, pipes, ducts, conduits, wires and appurtenant fixtures, wherever located in the
Premises, the Building, or elsewhere in the Property , provided that (a) no such installations,
replacements or relocations in the Premises shall be placed, to the extent reasonably practicable,
below dropped ceilings, to the inside of interior walls, or above floors and (b) all such work
necessitating entry into the Premises shall be subject to the provisions of Section 7.03; (ii) to
grant easements and other rights with respect to the Property, and (iii) to alter, relocate or
eliminate common areas and facilities in the Building, or on or serving the Property, including
with limitation the alteration or relocation (but not the elimination of) the Amenities, from time
to time so long as is there is no material adverse effect on access to, or use and occupancy of,
the Premises and all such additions, reconstruction and eliminations are consistent with a first
class office building in the suburban Boston area. Landlord shall use reasonable efforts not to
interfere with the conduct of Tenant’s business and to minimize the extent and duration of any
inconvenience, annoyance or disturbance to Tenant resulting from any work pursuant to this
paragraph in or about the Premises or Building, consistent with accepted construction practice, and
so long as Landlord uses such reasonable efforts Landlord shall not be liable to Tenant for any
compensation or reduction of Rent by reason of inconvenience or annoyance or for loss of business
resulting from any act by Landlord pursuant to this paragraph.

     Section 20.20. Tenant as non-Specially Designated National or Blocked Person. Tenant
hereby warrants, represents and certifies Tenant is not acting, directly or indirectly, for or on
behalf of any person, group, entity, or nation named by any Executive Order or the United States
Treasury Department as a terrorist, “Specially Designated National and Blocked Person”, or other
banned or blocked person, group, entity, nation, or transaction pursuant to any law, order, rule,
or regulation that is enforced or administered by the Office of Foreign Assets Control and that it
is not engaged in this transaction, directly or indirectly, on behalf of, or instigating or
facilitating this transaction, directly or indirectly, on behalf of any such person, group, entity,
or nation. Tenant agrees that any breach of the foregoing shall at Landlord’s election be a
default under this Lease for which there shall be no cure, and Tenant hereby agrees to defend,
indemnify, and hold harmless Landlord from and against any and all claims, damages, losses, risks,
liabilities, and expenses (including attorneys’ fees and costs) arising from or related to any
breach of the foregoing warranty, representation, and certification. Tenant acknowledges and
agrees that as a condition to the requirement or effectiveness of any consent to any Transfer

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by Landlord pursuant to Section 13.01, Tenant shall cause each Transferee (including any
Permitted Transferee), for the benefit of Landlord, to reaffirm, on behalf of such Transferee, the
representations of, and to otherwise comply with the obligations set forth in, this Section 20.20,
and it shall be reasonable for Landlord to refuse to consent to a Transfer in the absence of such
reaffirmation and compliance. Tenant agrees that breach of the representations and warranties set
forth in this Section 20.20 shall at Landlord’s election be a default under this Lease for which
there shall be no cure. This Section 20.20 shall survive the termination or earlier expiration of
the Lease.

     Section 20.21. Authority. Tenant warrants and represents that (a) Tenant is duly
organized, validly existing and in good standing under the laws of Massachusetts; (b) Tenant has
the authority to own its property and to carry on its business as contemplated under this Lease;
(c) Tenant is in compliance in all material respects with all laws and orders of public authorities
applicable to Tenant; (d) Tenant has duly executed and delivered this Lease; (e) the execution,
delivery and performance by Tenant of this Lease (i) are within the powers of Tenant, (ii) have
been duly authorized by all requisite action, (iii) will not violate any provision of law or any
order of any court or agency of government, or any agreement or other instrument to which Tenant is
a party or by which it or any of its property is bound, (iv) will not result in the imposition of
any lien or charge on any of Tenant’s Property, except by the provisions of this Lease; and (v) the
Lease is a valid and binding obligation of Tenant in accordance with its terms. Tenant agrees that
breach of the foregoing warranty and representation shall at Landlord’s election be a default under
this Lease for which there shall be no cure. This Section 20.21 shall survive the termination or
earlier expiration of the Lease.

     Section 20.22. Environmental Representation. Landlord represents and warrants that,
on the Delivery Date for each Portion of the Premises, such Portion of the Premises shall not
contain any Hazardous Materials other than materials customarily used in the construction or
operation of comparable suburban office buildings.

Article 21.

Rooftop License

     Section 21.01. Rooftop License. Landlord grants Tenants the appurtenant,
non-exclusive, and irrevocable (except upon the expiration or earlier termination of this Lease)
license at no additional charge, but otherwise subject to the terms and conditions of this Lease,
to use a contiguous portion of the roof of the Building approved by Landlord (the “Rooftop
Installation Areas”) to operate, maintain, repair and replace heating, ventilation and
air-conditioning equipment and telecommunications transmission and receiving equipment for Tenant’s
own use, such as a satellite dish, microwave dish, and the like, in each case appurtenant to the
Permitted Uses installed as part of Finish Work or otherwise as permitted pursuant to Article 8
(“Rooftop Equipment”). The exact location and layout of the Rooftop Installation Areas
shall be approved by Landlord in its reasonable discretion and shall not exceed in area the
Tenant’s Pro Rata Share of rooftop areas made available to tenants in the Building for similar
purposes.

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     Section 21.02. Installation and Maintenance of Rooftop Equipment. Tenant shall
install Rooftop Equipment at its sole cost and expense, at such times and in such manner as
Landlord may reasonably designate and in accordance with all of the provisions of this Lease,
including without limitation Article 8. Tenant shall not install or operate Rooftop Equipment
until it receives prior written approval of the plans for such work in accordance with Article 8.
Landlord may withhold approval if the installation or operation of Rooftop Equipment reasonably
would be expected to damage the structural integrity of the Building. Tenant shall cooperate with
Landlord as reasonably required to accommodate any re-roofing of the Building during the Lease term
and Tenant shall be responsible for any costs associated with moving or temporarily relocation
Tenant’s Roof Equipment to the extent such Rooftop Equipment is not attached to the roof with
permanent flashing or equivalent measures consistent with the permanent installation of such
Rooftop Equipment (as opposed to surface mounting or use of ballasts). Tenant’s access to the
rooftop for the purposes of exercising its rights and obligations under this Article 21 shall be
limited to Normal Business Hours by prior appointment with the property manager, except in the case
of emergencies threatening life or personal property.

     Tenant shall engage Landlord’s roofer before beginning any rooftop installations or repairs of
Rooftop Equipment, whether under this Article 21 or otherwise, and shall always comply with the
roof warranty governing the protection of the roof and modifications to the roof. Tenant shall
obtain a letter from Landlord’s roofer following completion of such work stating that the roof
warranty remains in effect. Tenant, at its sole cost and expense, shall cause a qualified
contractor to inspect the Rooftop Installation Areas periodically (and at least two times per year)
and correct any loose bolts, fittings or other appurtenances and shall repair any damage to the
roof caused by the installation or operation of Rooftop Equipment. Tenant shall pay Landlord
following a written request therefor, with the next payment of Rent, (i) all applicable taxes or
governmental charges, fees, or impositions imposed on Landlord because of Tenant’s use of the
Rooftop Installation Areas and (ii) the amount of any increase in Landlord’s insurance premiums as
a result of the installation of Rooftop Equipment. All Rooftop Equipment shall be screened or
otherwise designed so that it is not visible from the ground level of the Property.

     Section 21.03. Indemnification. Indemnification. Tenant agrees that the
installation, operation and removal of Rooftop Equipment shall be at its sole risk. Tenant shall
indemnify and defend Landlord and the other Indemnitees against any liability, claim or cost,
including reasonable attorneys’ fees, incurred in connection with the loss of life, personal
injury, damage to property or business or any other loss or injury (except to the extent due to the
negligence or willful misconduct of Landlord or its employees, agents, or contractors) arising out
of the installation, use, operation, or removal of Rooftop Equipment by Tenant or its employees,
agents, or contractors, including any liability arising out of Tenant’s violation of this Article
21. Subject to the provisions of Section 21.05, Landlord assumes no responsibility for
interference in the operation of Rooftop Equipment caused by other tenants’ equipment, or for
interference in the operation of other tenants’ equipment caused by Rooftop Equipment; provided,
however, that Landlord shall use commercially reasonable efforts to enforce the rights of Tenant
under this Lease to the extent the same are superior to that of any other tenants of the Property
and shall comply with the provisions of Section 21.05, below. The provisions of this Section 21.03
shall survive the expiration or earlier termination of this Lease.

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     Section 21.04. Removal of Rooftop Equipment. Upon the expiration or earlier
termination of the Lease, Tenant, at its sole cost and expense, shall (i) remove Rooftop Equipment
from the Rooftop Installation Areas in accordance with the provisions of this Lease and (ii) leave
the Rooftop Installation Areas in good order and repair, reasonable wear and tear excepted. If
Tenant does not remove Rooftop Equipment when so required, Landlord may remove and dispose of it
and charge Tenant for all costs and expenses incurred.

     Section 21.05. Interference by Rooftop Equipment. Landlord may grant future roof
rights to other parties, and Landlord shall be contractually obligated to cause such other parties
to eliminate and avoid interference with Rooftop Equipment to the same or greater extent as Tenant
is so obligated. If Rooftop Equipment (i) causes physical damage to the structural integrity of
the Building, (ii) materially interferes with any telecommunications, mechanical or other systems
located at or servicing (as of the initial Delivery Date) the Building, or (iii) interferes with
any other service provided to other tenants in the Building by rooftop installations installed
prior to the installation of Rooftop Equipment, in each case in excess of that permissible under
F.C.C. or other regulations (to the extent that such regulations apply and do not require such
tenants or those providing such services to correct such interference or damage), Tenant shall
within five (5) business days of notice of a claim of interference or damage cooperate with
Landlord or any other tenant or third party making such claim to determine the source of the damage
or interference and effect a prompt solution at Tenant’s expense (if Rooftop Equipment caused such
interference or damage). In the event Tenant disputes Landlord’s allegation that Rooftop Equipment
is causing a problem with the Building (including, but not limited to, the electrical, HVAC, and
mechanical systems of the Building) and/or any other Building tenants’ equipment in the Building,
in writing delivered within five (5) business days of receiving Landlord’s notice claiming such
interference, then Landlord and Tenant shall meet to discuss a solution, and if within seven (7)
days of their initial meeting Landlord and Tenant are unable to resolve the dispute, then the
matter shall be submitted to arbitration in accordance with the provisions set forth below.

     The parties shall direct the Boston office of the AAA to appoint an arbitrator who shall have
a minimum of ten (10) years experience in commercial real estate disputes and who shall not be
affiliated with either Landlord or Tenant. Both Landlord and Tenant shall have the opportunity to
present evidence and outside consultants to the arbitrator. The arbitration shall be conducted in
accordance with the commercial real estate arbitration rules of the AAA insofar as such rules are
not inconsistent with the provisions of this Lease (in which case the provisions of this Lease
shall govern). The cost of the arbitration (exclusive of each party’s witness and attorneys’ fees,
which shall be paid by such party) shall be borne equally by the parties. Within ten (10) days of
appointment, the arbitrator shall determine whether or not Rooftop Equipment is causing a problem
with the Building and/or any other Building tenants’ equipment in the Building, and the appropriate
resolution, if any. The arbitrator’s decision shall be final and binding on the parties. If
Tenant shall fail to cooperate with Landlord in resolving any such interference or if Tenant shall
fail to implement the arbitrator’s decision within ten (10) days after it is issued, Landlord may
at any time thereafter (i) declare an Event of Default and/or (ii) relocate the item(s) of Rooftop
Equipment in dispute in a manner consistent with the arbitral decision.

- 58 -

 

     Section 21.06. Relocation of Rooftop Equipment. Based on Landlord’s good faith
determination that such a relocation is necessary, Landlord reserves the right to cause Tenant to
relocate Rooftop Equipment located on the roof to comparably functional space on the roof by giving
Tenant prior notice of such intention to relocate. If within thirty (30) days after receipt of
such notice Tenant has not agreed with Landlord on the space to which Rooftop Equipment is to be
relocated , the functional utility of such location, the timing of such relocation, and the terms
of such relocation, then either party may submit such dispute to arbitration pursuant to Section
21.05, above (except that the arbitrators determination shall be of the space to which Rooftop
Equipment is to be relocated, the timing of such relocation, and the terms of such relocation).
Landlord agrees to pay the reasonable cost of moving Rooftop Equipment to such other space, taking
such other steps necessary to ensure comparable functionality of Rooftop Equipment, and finishing
such space to a condition comparable to the then condition of the current location of Rooftop
Equipment. Such payment by Landlord shall not constitute an Operating Expense under this Lease.
Tenant shall arrange for the relocation of Rooftop Equipment within sixty (60) days after a
comparable space is agreed upon or determined by arbitration, as the case may be. In the event
Tenant fails to arrange for said relocation within the sixty (60) day period, Landlord shall have
the right to arrange for the relocation of Rooftop Equipment at Landlord’s expense, all of which
shall be performed in a manner designed to minimize interference with Tenant’s business.

Article 22.

Extension Options

     Section 22.01. Option to Extend. Provided that (i) Tenant is not in default
hereunder, after any applicable notice and cure periods have expired, at the time Tenant gives its
Extension Notice or at the time the applicable Option Term would commence, or (ii) no sublets of
more than 50% of the Premises are then in effect that required Landlord’s consent under Article 13,
Tenant shall have the right, at its election, to extend the original term of this Lease for two (2)
additional periods of five (5) years each (each, an “Option Term”) commencing upon the
expiration of the original term or first Option Term, as applicable, provided that Tenant shall
give Landlord an irrevocable (except as expressly set forth in Section 22.04) written notice (an
“Extension Notice”) in the manner provided in Section 18.01 of the exercise of its election
to so extend at least twelve (12) months, and no more than fifteen (15) months prior to the
expiration of the term (as the same may have been extended) of this Lease. Except for this Article
22 with respect to the second such Option Term, the provisions of the Work Letter, and as expressly
otherwise provided in this Lease, all the agreements and conditions in this Lease contained shall
apply to the applicable Option Term, including without limitation the obligation to pay Additional
Rent for Tenant’s Pro Rata Share of Taxes and Tenant’s Pro Rata Share of Operating Expenses. If
Tenant shall give written notice as provided in Section 18.01 of the exercise of the election in
the manner and within the time provided aforesaid, the term shall be extended upon the giving of
the notice without the requirement of any action on the part of Landlord.

- 59 -

 

     Section 22.02. Extension Rent. The annual Base Rent payable during any Option Term
shall be the greater of (x) ninety-five percent (95%) of the Market Rent as determined in the
manner set forth in Section 22.03, 22.04 and 22.05, below, or (y) $27.05 per rentable square foot
per annum. If the annual Base Rent for any Option Term has not been determined by the commencement
date of such Option Term, Tenant shall pay Base Rent at the last annual rental rate in effect for
the expiring Term until such time as annual Base Rent for the Option Term has been determined.
Upon such determination, the Base Rent for the Premises shall be retroactively adjusted to the
commencement of the Option Term. If such adjustment results in an underpayment of Base Rent by
Tenant, Tenant shall pay Landlord the amount of such underpayment within 30 days after the
determination thereof. If such adjustment results in an overpayment of Base Rent by Tenant,
Landlord shall credit such overpayment against the next installment of Base Rent due under the
Lease and, to the extent necessary, any subsequent installments, until the entire amount of such
overpayment has been credited against Base Rent.

     Section 22.03. Market Rent. If Tenant gives Landlord timely notice of its election to
extend the then current term of this Lease, then within thirty (30) days thereafter, Landlord shall
give Tenant written notice of Landlord’s estimate of the then applicable market rent for Tenant’s
space, based on the rent for similar space in the Property and rent for similar space in similar
first class suburban office buildings in Waltham area (the “Market Rent”) for the Premises
in its then as-is condition (or such better condition as Tenant shall be required to maintain under
this Lease), taking into account all of the factors that a landlord and tenant would consider in
negotiating an arms-length rent (however, in no event shall the determination of Market Rent treat
any portion of the Premises as being used for research or laboratory purposes, but rather that said
determination of Market Rent shall treat the entire Premises as being used for office purposes for
the purposes of determining such Market Rent). For each year of an Option Term after the first
year of such Option Term, Base Rent shall never be decreased below that paid in the prior lease
year, but may or may not, on account of the determination of Market Rent, increase.

     Section 22.04. Tenant’s Right to Dispute Market Rent. In the event that Tenant
disputes the Market Rent estimate provided by Landlord, Tenant may, within 15 days of its receipt
of notice from Landlord estimating such Market Rent, either (i) elect to withdraw its request for
an extension, in which case there shall be no extension of the term of this Lease, or (ii) give
notice to Landlord of such dispute and require that both Landlord and Tenant enter into a 15 day
good faith negotiating period to see if Landlord and Tenant come to a mutual agreement in
establishing the Market Rent. If Landlord and Tenant can come to agreement as to the Market Rent
within such 15 day period, then the Market Rent shall be set for the purposes of the Option Term as
the parties agree. If Landlord and Tenant cannot come to an agreement in establishing Market Rent
within such 15 day period, then Tenant may either (x) elect to withdraw its request for an
extension, in which case there shall be no extensions of the term of this lease, or (y) give notice
to Landlord requiring that the establishment of the Market Rent be submitted to arbitration in
accordance with the terms set forth in Section 22.05 below. If Tenant does not so dispute
Landlord’s estimated Market Rent within the 15 day period first referenced in this paragraph,
Tenant shall be deemed to have accepted Landlord’s estimate of Market Rent. In no event shall the

- 60 -

 

extension of the term of this Lease be affected by the determination of the Market Rent, such
exercise of extension being fixed at the time at which notice is given (subject to the provisions
of clauses (i) and (x), above).

     Section 22.05. Arbitration of Market Rent.  In the event Landlord and Tenant shall be
unable to agree on the then Market Rent for the purposes of determining the Base Rent for the
applicable Option Term, then Market Rent shall be established in the following manner of
arbitration:

               (a) Each of Tenant and Landlord shall choose an arbitrator knowledgeable in the field of
establishing fair rental values in the Waltham Class A office market;

               (b) The arbitrators selected in accordance with “(a)” above shall select a third arbitrator
who is a qualified real estate appraiser with at least ten (10) years’ experience in the appraisal
of first class office buildings in the Waltham Class A office market;

               (c) The selections shall be completed no later than twenty-one (21) days after Tenant’s notice
requiring the arbitration of Market Rent. If any selection is not made within the 21-day time
period, either party may petition the Boston office of the AAA to make the selection;

               (d) Within thirty (30) days after their appointment, the arbitrators shall determine the
Market Rent for the Premises for the Option Term, and shall notify Tenant and Landlord of such
determination within seven (7) days, which determination shall be final and binding upon Tenant and
Landlord. If the arbitrators are unable to agree upon the Market Rent, the Market Rent will be
deemed to be the average of the Market Rents proposed by the arbitrators, except that (i) if the
lowest proposed Market Rent is less than 90% of the second to lowest proposed fair market rent, the
lowest proposed Market Rent will automatically be deemed to be 90% of the second to lowest proposed
Market Rent and (ii) if the highest proposed Market Rent is greater than 110% of the second to
highest proposed Market Rent, the highest proposed Market Rent will automatically be deemed to be
110% of the second to highest proposed Market Rent.

               (e) The foregoing arbitration shall be conducted in accordance with the commercial arbitration
rules of the AAA or its successors;

               (f) Landlord and Tenant shall each pay all costs of the arbitrator it selected and one-half
(1/2) of all other costs of the arbitration proceedings.

- 61 -

 

     For the purpose of determining Market Rent the parties shall use as a guideline the average
rental rates for similar available office space (and shall value the subject space as 100% office
space without regard for any research or laboratory use by Tenant) in similar office buildings in
the Waltham market.

Article 23.

Right of First Refusal

     Section 23.01. Right of First Refusal. Prior to January 17, 2011 (the “RFR
Termination Date”), before entering into the initial lease for all or any portion of the third
floor of the Building not initially leased to Tenant hereunder or any portion of the first floor of
the Building shown on the attached Exhibit 23.01 (collectively, the “First Refusal
Space”) with a third party (other than Exempt RFR Transactions, as defined below), and provided
that Landlord has received a written proposal or counter-proposal for the applicable First Refusal
Space that Landlord is willing to accept (or Landlord has received an acceptance of a proposal
initiated by Landlord, whether or not such acceptance is binding), Landlord shall offer the
applicable First Refusal Space to Tenant for lease by written notice to Tenant (“Landlord’s FR
Notice”). Within five (5) business days after receipt of Landlord’s FR Notice, Tenant may, by
written notice delivered to Landlord, (i) reject Landlord’s FR Notice, or (ii) accept Landlord’s
offer to lease such space for its own use on the terms set forth in this Article 23 (the failure by
Tenant to timely respond as aforesaid being deemed Tenant’s rejection of Landlord’s FR Notice
pursuant to clause (i), above).

     If Landlord’s FR Notice is rejected under clause (i) above (or deemed rejected by Tenant’s
failure to timely respond), then Landlord may enter into any lease for such space on materially the
same terms set forth in such Landlord’s FR Notice, provided that Landlord shall deliver to Tenant a
new Landlord’s FR Notice prior to entering into an initial lease for the applicable First Refusal
Space (a) with any third party other than the party (or an affiliate of the party) that previously
made the offer to, or accepted an offer from, Landlord giving rise to such prior Landlord’s FR
Notice, or (b) on terms materially more favorable to the party (or an affiliate of the party) that
previously made the offer to, or accepted an offer from, Landlord giving rise to such prior
Landlord’s FR Notice, than those terms set forth in such prior Landlord’s FR Notice (it being
agreed that a net effective rental rate (after taking into account base rent, tenant improvement
allowances, free rent and other concessions) of at least 95% of the net effective rental rate set
forth in Landlord’s FR Notice does not constitute materially more favorable terms).

     If Tenant timely accepts Landlord’s offer to lease the space as set forth in clause (ii)
above, the space shall, subject to the following paragraph below and without further action by the
parties, be leased by Tenant in its “as is” condition, without any obligation to construct tenant
or other improvements (except that Landlord shall be responsible, at Landlord’s sole cost and
expense, to separately demise the space), and otherwise on the terms and conditions then applicable
to the remainder of the Premises (e.g. the Base Rent shall be at the then-applicable rate,
escalating as otherwise provided in Section 2.01) except that (x) the Finish Work

- 62 -

 

Allowance shall be reduced with respect to the applicable First Refusal Space on a pro rata
basis for the actual initial lease term for such First Refusal Space (e.g. if the term of the First
Refusal Space is eight years, then the Finish Work Allowance for the First Refusal Space would be
96/126ths of the Finish Work Allowance applicable to the remainder of the Premises on a per square
foot basis), (y) the rent commencement date with respect to the applicable First Refusal Space
shall be no later than the later to occur of (i) the Rent Commencement Date for the Office Portion
of the Premises or (ii) seven (7) months after the execution of the amendment described in the
immediately following sentence, and (z) the estimated delivery date that Landlord shall deliver the
applicable First Refusal Space to Tenant for the commencement of construction of any Tenant Work
shall be no later than the sixty (60) days after the execution of the amendment described in the
immediately following sentence. At the request of either party, Landlord and Tenant shall promptly
execute and deliver an agreement confirming such expansion of the Premises and the estimated date
the Premises are to be expanded pursuant to this Paragraph with a provision for establishing the
effective date of such expansion based on actual delivery. Tenant shall execute any such amendment
within 21 days following tender by Landlord provided that such amendment complies with the terms of
this Article 23. If Landlord fails to deliver the First Refusal Space within 90 days of the
estimated delivery date set forth in Landlord’s FR Notice, then Tenant, at its option, may either
(x) terminate its obligations with respect to the First Refusal Space upon 30 days prior written
notice to Landlord, whereupon all obligations of the parties hereto with respect to the First
Refusal Space shall be null and void and without recourse to either party unless Landlord delivers
the First Refusal Space within such 30 day period, in which case Tenant’s termination notice shall
be null and void and of no further force and effect or (y) if such failure results from matters
within Landlord’s reasonable control and is not cured within 30 days following written notice from
Tenant, pursue any of its equitable remedies to cause Landlord to deliver such First Refusal Space
to Tenant and bring a claim for monetary damages against Landlord, but in no event shall such
failure constitute a default of Landlord, result in a right of Tenant to terminate the Lease with
respect to the remainder of the Premises, or affect the validity of the Lease.

     In no event shall the rights under this Section 23.01 apply to (x) leases subsequent to the
initial lease or leases of all or any portion of the First Refusal Space (such leases, “Initial
Leases”), or (y) any space offered to lease for use as a building amenity, such as a cafeteria
or fitness center (collectively, “Exempt RFR Transactions”).

     Notwithstanding any provision of this Section to the contrary, Tenant’s rights under this
Section shall terminate on the RFR Termination Date and shall be void, at Landlord’s election, if
(i) Tenant is in default hereunder, after any applicable notice and cure periods have expired, at
any time prior to the time Tenant makes any election with respect to the First Refusal Space under
this Section or at the time the First Refusal Space would be added to the Premises, or (ii)
subleases of more than 50% of the Premises are in effect that required Landlord’s consent under
Article 13 at the time Tenant makes any election with respect to the First Refusal Space under this
Section or at the time the First Refusal Space would be added to the Premises.

     In connection with the rights granted under this Article 23, Landlord shall, prior to the RFR
Termination Date, keep Tenant reasonably informed from time to time of the leasing status of any
then-available Right of First Refusal space.

- 63 -

 

Article 24.

Right of First Offer

     Section 24.01. Right of First Offer. Following the RFR Termination Date, before
entering into a lease for all or any portion of the Building (the “First Offer Space”) with
a third party (other than Exempt RFO Transactions, as defined below), Landlord shall notify Tenant
of the terms on which Landlord intends to lease the space (“Landlord’s FO Notice”). Within
five (5) business days after receipt of Landlord’s FO Notice, Tenant may, by written notice
delivered to Landlord, (i) reject Landlord’s FO Notice, or (ii) unconditionally and irrevocably
accept Landlord’s offer to lease such space for its own use on the terms set forth in Landlord’s FO
Notice (the failure by Tenant to timely respond as aforesaid being deemed Tenant’s rejection of
Landlord’s FO Notice pursuant to clause (i), above).

     If Landlord’s FO Notice is rejected under clause (i) above (or deemed rejected by Tenant’s
failure to timely respond), then Landlord may enter into any lease for such space on materially the
same net financial terms set forth in such Landlord’s FO Notice, provided that Landlord shall
deliver to Tenant a new Landlord’s FO Notice prior to entering into an initial lease for the First
Offer Space providing for a net effective rental rate (taking into account base rent, tenant
improvement allowances, free rent and other concessions) more than five (5) percent less than that
specified in Landlord’s FO Notice.

     If Tenant timely accepts Landlord’s offer to lease the space as set forth in clause (ii)
above, then the space shall, subject to the following paragraph below and without further action by
the parties, be leased by Tenant on the accepted terms (but in any event for a term not less than
the shorter of three years or the then-remaining term of this Lease) and otherwise on all of the
terms of the Lease in effect immediately prior to such expansion, provided that, at the request of
either party, Landlord and Tenant shall promptly execute and deliver an agreement confirming such
expansion of the Premises and the estimated date the Premises are to be expanded pursuant to this
Paragraph with a provision for establishing the effective date of such expansion based on actual
delivery. Except as otherwise agreed by the parties in writing, Landlord’s failure to deliver, or
delay in delivering, all or any part of the First Offer Space, for any reason, shall not alter
Tenant’s obligation to accept such space when delivered, shall not constitute a default of
Landlord, and shall not affect the validity of the Lease, provided, however, that if Landlord fails
to deliver the First Offer Space within 180 days of the date set forth for delivery in Landlord’s
FO Notice, then Tenant, at its sole option, may terminate its obligations with respect to the First
Offer Space upon 30 days prior written notice to Landlord, whereupon all obligations of the parties
hereto with respect to the First Offer Space shall be null and void and without recourse to either
party unless Landlord delivers the First Offer Space within such 30 day period, in which case
Tenant’s termination notice shall be null and void and of no further force and effect. Landlord
shall use commercially reasonable efforts to commence and diligently prosecute legal action to
evict any tenant holding over in First Offer Space subject to an accepted offer by Tenant pursuant
to this Section 24.01 commencing no later than the date that is 30 days following the date that
Landlord is anticipated to deliver such First Offer Space to Tenant.

- 64 -

 

     In no event shall the rights under this Section 24.01 apply to (x) the initial lease for all
or any portion of the First Offer Space and the renewal or extension thereof (such leases,
“Initial Leases”), (y) any space offered to lease for use as a building amenity, such as a
cafeteria or fitness center, or (z) solely with respect to the first and second floor portions of
the First Offer Space, the exercise of an expansion right by a then-existing Building tenant or the
renewal or extension of leases by occupants of the first and second floor (collectively,
“Exempt RFO Transactions”).

     Notwithstanding any provision of this Section to the contrary, Tenant’s rights under this
Section shall terminate on the date that is one year prior to the Expiration Date and shall be
void, at Landlord’s election, if (i) Tenant is in default hereunder, after any applicable notice
and cure periods have expired, at any time prior to the time Tenant makes any election with respect
to the First Offer Space under this Section or at the time the First Offer Space would be added to
the Premises, or (ii) subleases of more than 50% of the Premises are in effect that required
Landlord’s consent under Article 13 at the time Tenant makes any election with respect to the First
Offer Space under this Section or at the time the First Offer Space would be added to the Premises.
Nothing in this Section shall be construed to grant to Tenant any rights or interest in any space
in the Building, and any claims by Tenant alleging a failure of Landlord to comply herewith shall
be limited to claims for monetary damages. Tenant may not assert and hereby waives any rights in
any space nor file any lis pendens or similar notice with respect thereto.

Article 25.

Expansion Option

     Section 25.01. Expansion Option. Tenant shall have the right to request that Landlord
pursue the expansion of the Building by approximately 45,000 rentable square feet upon at least 30
days prior written notice to Landlord. Following the giving of such written notice, Landlord and
Tenant shall cooperate in good faith to agree upon a schedule and budget for any such expansion,
which shall include a pre-development phase for permitting. Any such expansion shall be
conditioned upon (i) the parties entering into a mutually agreeable lease amendment at market rent
(taking into account the current building financing, financing available in the market, and
allowing a market return to Landlord on its costs to construct such expansion) and for a term of at
least 10 years (which may be achieved by use of any extension options under the Lease then
remaining) and (ii) Landlord’s ability to obtain the necessary permits for such expansion (using
good faith, commercially reasonable efforts to do so). Tenant shall have no right to request an
expansion under this section at any time that an Event of Default then exists, if Tenant ceases to
occupy at least 66% of the Premises, or if, at the time Tenant gives its notice or at any time
thereafter, there are at least 45,000 rentable square feet available for lease in the Building.

     It is intended that this instrument will take effect as a sealed instrument.

- 65 -

 

[Remainder of page intentionally left blank.]

- 66 -

 

     IN WITNESS WHEREOF, the Landlord and Tenant have signed the same as of the date first
appearing above.

	 	 	 	 	 	 	 	 	 
	 	 	LANDLORD:	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	PDM 850 UNIT, LLC	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	By:	 	PD Winter Street, LLC, its sole member	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	 	 	By :
	 	/s/ Paul R. Marcus
 

Name: Paul R. Marcus
	 	 
	 

	 	 	 	 	 	Title: A Member of Its Executive Committee	 	 

	 	 	 	 	 
	 	TENANT:

ALKERMES, INC.

 	 
	 	By:  	/s/ Gordon G. Pugh
 	 
	 	 	Name: Gordon G. Pugh	 
	 	 	Title: Chief Operating Officer	 
	 
	 	 	 
	 	By:  	     /s/ James M. Frates
 	 
	 	 	Name:  	James M. Frates 	 
	 	 	Title:  	Chief Financial Officer 	 
	 

- 67 -EX-4.6

Exhibit 4.6

THE WILLIAMS COMPANIES, INC.

AND

THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.

Trustee

 

INDENTURE

Dated as of [ ____________ ]

Debt Securities

 

 

Reconciliation and tie between

Trust Indenture Act of 1939, as amended,

and the Indenture

	 	 	 
	Trust Indenture Act Section	 	Indenture Section
	(S)310(a)(1)
	 	608
	(a)(2)
	 	608
	(b)
	 	609
	(S)312(a)
	 	701
	(b)
	 	702
	(c)
	 	702
	(S)313(a)
	 	703
	(b)(2)
	 	703
	(c)
	 	703
	(d)
	 	703
	(S)314(a)
	 	704
	(c)(1)
	 	102
	(c)(2)
	 	102
	(e)
	 	102
	(f)
	 	102
	(S)316(a) (last sentence)
	 	101
	(a)(1)(A)
	 	502, 512
	(a)(1)(B)
	 	513
	(b)
	 	508
	(S)317(a)(1)
	 	503
	(a)(2)
	 	504
	(b)
	 	1003
	(S)318(a)
	 	108

Note: This reconciliation and tie shall not, for any purpose, be deemed to be part of the
Indenture.

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 
	 	 	 	 	Page
	ARTICLE ONE DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION	 	 	1	 
	Section 101

	 	Definitions; Rules of Construction.
	 	 	1	 
	Section 102

	 	Compliance Certificates and Opinions.
	 	 	11	 
	Section 103

	 	Form of Documents Delivered to Trustee.
	 	 	11	 
	Section 104

	 	Acts of Holders.
	 	 	12	 
	Section 105

	 	Notices, etc. to Trustee and Company.
	 	 	14	 
	Section 106

	 	Notice to Holders of Securities; Waiver.
	 	 	14	 
	Section 107

	 	Language of Notices.
	 	 	14	 
	Section 108

	 	Incorporation by Reference
of Trust Indenture Act; Trust
Indenture Act Controls.
	 	 	15	 
	Section 109

	 	Effect of Headings and Table of Contents.
	 	 	15	 
	Section 110

	 	Successors and Assigns.
	 	 	15	 
	Section 111

	 	Separability Clause.
	 	 	15	 
	Section 112

	 	Benefits of Indenture.
	 	 	15	 
	Section 113

	 	Governing Law; Waiver of Trial by Jury.
	 	 	16	 
	Section 114

	 	Legal Holidays.
	 	 	16	 
	Section 115

	 	Counterparts.
	 	 	16	 
	Section 116

	 	Judgment Currency.
	 	 	16	 
	Section 117

	 	Limitation on Individual Liability.
	 	 	17	 
	ARTICLE TWO SECURITIES FORMS
	 	 	17	 
	Section 201

	 	Forms Generally.
	 	 	17	 
	Section 202

	 	Form of Trustee’s Certificate of Authentication.
	 	 	18	 
	Section 203

	 	Securities in Global Form.
	 	 	18	 
	ARTICLE THREE THE SECURITIES
	 	 	19	 
	Section 301

	 	Amount Unlimited; Issuable in Series.
	 	 	19	 
	Section 302

	 	Currency; Denominations.
	 	 	23	 
	Section 303

	 	Execution, Authentication, Delivery and Dating.
	 	 	23	 
	Section 304

	 	Temporary Securities.
	 	 	24	 
	Section 305

	 	Registration, Transfer and Exchange.
	 	 	25	 
	Section 306

	 	Mutilated, Destroyed, Lost and Stolen Securities.
	 	 	29	 
	Section 307

	 	Payment of Interest and Certain Additional
Amounts; Rights to Interest and Certain
Additional Amounts Preserved.
	 	 	30	 

i

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 	 	 
	 	 	 	 	Page
	Section 308

	 	Persons Deemed Owners.
	 	 	31	 
	Section 309

	 	Cancellation.
	 	 	32	 
	Section 310

	 	Computation of Interest.
	 	 	32	 
	Section 311

	 	CUSIP and ISIN Numbers.
	 	 	32	 
	ARTICLE FOUR SATISFACTION AND DISCHARGE OF INDENTURE	 	 	32	 
	Section 401

	 	Satisfaction and Discharge.
	 	 	32	 
	Section 402

	 	Defeasance and Covenant Defeasance.
	 	 	34	 
	Section 403

	 	Application of Trust Money.
	 	 	37	 
	Section 404

	 	Qualifying Trustee.
	 	 	38	 
	ARTICLE FIVE REMEDIES	 	 	38	 
	Section 501

	 	Events of Default.
	 	 	38	 
	Section 502

	 	Acceleration of Maturity; Rescission and Annulment.
	 	 	39	 
	Section 503

	 	Collection of Indebtedness and Suits for Enforcement by Trustee.
	 	 	40	 
	Section 504

	 	Trustee May File Proofs of Claim.
	 	 	41	 
	Section 505

	 	Trustee May Enforce Claims without Possession of Securities .
	 	 	42	 
	Section 506

	 	Application of Money Collected.
	 	 	42	 
	Section 507

	 	Limitations on Suits.
	 	 	42	 
	Section 508

	 	Unconditional Right of Holders to Receive Principal and any
Premium, Interest and Additional Amounts.
	 	 	43	 
	Section 509

	 	Restoration of Rights and Remedies.
	 	 	43	 
	Section 510

	 	Rights and Remedies Cumulative.
	 	 	43	 
	Section 511

	 	Delay or Omission Not Waiver.
	 	 	44	 
	Section 512

	 	Control by Holders of Securities.
	 	 	44	 
	Section 513

	 	Waiver of Past or Existing Defaults.
	 	 	44	 
	Section 514

	 	Waiver of Stay or Extension Laws.
	 	 	45	 
	Section 515

	 	Undertaking for Costs.
	 	 	45	 
	ARTICLE SIX THE TRUSTEE	 	 	45	 
	Section 601

	 	Certain Duties and Responsibilities.
	 	 	45	 
	Section 602

	 	Certain Rights of Trustee.
	 	 	46	 
	Section 603

	 	Notice of Defaults.
	 	 	48	 
	Section 604

	 	Not Responsible for Recitals or Issuance of Securities.
	 	 	48	 

ii

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 	 	 
	 	 	 	 	Page
	Section 605

	 	May Hold Securities.
	 	 	49	 
	Section 606

	 	Money Held in Trust.
	 	 	49	 
	Section 607

	 	Compensation and Reimbursement.
	 	 	49	 
	Section 608

	 	Corporate Trustee Required; Eligibility; Conflicting Interests.
	 	 	50	 
	Section 609

	 	Resignation and Removal; Appointment of Successor.
	 	 	51	 
	Section 610

	 	Acceptance of Appointment by Successor.
	 	 	52	 
	Section 611

	 	Merger, Conversion, Consolidation or Succession to Business.
	 	 	54	 
	Section 612

	 	Appointment of Authenticating Agent.
	 	 	54	 
	ARTICLE SEVEN HOLDERS LISTS AND REPORTS BY TRUSTEE AND COMPANY	 	 	56	 
	Section 701

	 	Company to Furnish Trustee Names and Addresses of Holders.
	 	 	56	 
	Section 702

	 	Preservation of Information; Communications to Holders.
	 	 	57	 
	Section 703

	 	Reports by Trustee.
	 	 	57	 
	Section 704

	 	Reports by Company.
	 	 	57	 
	ARTICLE EIGHT CONSOLIDATION, MERGER AND SALES	 	 	58	 
	Section 801

	 	Company May Consolidate, etc., Only on Certain Terms.
	 	 	58	 
	Section 802

	 	Successor Person Substituted for Company.
	 	 	59	 
	ARTICLE NINE SUPPLEMENTAL INDENTURES	 	 	59	 
	Section 901

	 	Supplemental Indentures without Consent of Holders.
	 	 	59	 
	Section 902

	 	Supplemental Indentures With Consent of Holders.
	 	 	61	 
	Section 903

	 	Execution of Supplemental Indentures.
	 	 	62	 
	Section 904

	 	Revocation of Consents.
	 	 	62	 
	Section 905

	 	Effect of Supplemental Indentures.
	 	 	63	 
	Section 906

	 	Reference in Securities to Supplemental Indentures.
	 	 	63	 
	Section 907

	 	Conformity with Trust Indenture Act.
	 	 	63	 
	Section 908

	 	Notice of Supplemental Indenture.
	 	 	63	 
	ARTICLE TEN COVENANTS	 	 	64	 
	Section 1001

	 	Payment of Principal, any Premium, Interest
and Additional
Amounts.
	 	 	64	 
	Section 1002

	 	 Maintenance of Office or Agency.
	 	 	64	 
	Section 1003

	 	 Money for Securities Payments to Be Held in Trust.
	 	 	64	 

iii

 

TABLE OF CONTENTS

(continued)

	 	 	 	 	 	 	 
	 	 	 	 	Page
	Section 1004

	 	Additional Amounts.
	 	 	66	 
	Section 1005

	 	Waiver of Certain Covenants.
	 	 	67	 
	Section 1006

	 	Company Statement as to Compliance.
	 	 	67	 
	ARTICLE ELEVEN REDEMPTION OF SECURITIES	 	 	67	 
	Section 1101

	 	Applicability of Article.
	 	 	67	 
	Section 1102

	 	Election to Redeem; Notice to Trustee.
	 	 	67	 
	Section 1103

	 	Selection by Trustee of Securities to be Redeemed.
	 	 	68	 
	Section 1104

	 	Notice of Redemption.
	 	 	68	 
	Section 1105

	 	Deposit of Redemption Price.
	 	 	70	 
	Section 1106

	 	Securities Payable on Redemption Date.
	 	 	70	 
	Section 1107

	 	Securities Redeemed in Part.
	 	 	70	 
	Section 1108

	 	Repurchases on the Open Market.
	 	 	71	 
	ARTICLE TWELVE SINKING FUNDS	 	 	71	 
	Section 1201

	 	Applicability of Article.
	 	 	71	 
	Section 1202

	 	Satisfaction of Sinking Fund Payments with Securities.
	 	 	71	 
	Section 1203

	 	Redemption of Securities for Sinking Fund.
	 	 	72	 
	ARTICLE THIRTEEN REPAYMENT AT THE OPTION OF HOLDERS	 	 	72	 
	Section 1301

	 	Applicability of Article.
	 	 	72	 
	ARTICLE FOURTEEN SECURITIES IN FOREIGN CURRENCIES	 	 	73	 
	Section 1401

	 	Applicability of Article.
	 	 	73	 
	ARTICLE FIFTEEN MEETINGS OF HOLDERS OF SECURITIES	 	 	73	 
	Section 1501

	 	Purposes for Which Meetings May Be Called.
	 	 	73	 
	Section 1502

	 	Call, Notice and Place of Meetings.
	 	 	73	 
	Section 1503

	 	Persons Entitled to Vote at Meetings.
	 	 	74	 
	Section 1504

	 	Quorum; Action.
	 	 	74	 
	Section 1505

	 	Determination of Voting Rights; Conduct and Adjournment of
Meetings.
	 	 	75	 
	Section 1506

	 	Counting Votes and Recording Action of Meetings.
	 	 	75	 

iv

 

     INDENTURE (the “Indenture”), dated as of [                    ], between THE
WILLIAMS COMPANIES, INC., a corporation existing under the laws of the State of Delaware (the
“Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking
association, duly organized and validly existing under the laws of the United States of America, as
trustee (the “Trustee”).

RECITALS

     The Company has duly authorized the execution and delivery of this Indenture to provide for
the issuance from time to time of its debentures, notes or other evidences of indebtedness
(hereinafter called the “Securities”), unlimited as to principal amount, to bear such rates
of interest, to mature at such time or times, to be issued in one or more series and to have such
other provisions as shall be fixed as hereinafter provided.

     All things necessary to make this Indenture a valid and legally binding agreement of the
Company, in accordance with its terms, have been done.

     NOW, THEREFORE, THIS INDENTURE WITNESSETH:

     For and in consideration of the premises and the purchase of the Securities by the Holders (as
herein defined) thereof, it is mutually covenanted and agreed, for the equal and proportionate
benefit of all Holders of the Securities or of any series thereof as follows:

ARTICLE ONE

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION

Section 101 Definitions; Rules of Construction.

     Except as otherwise expressly provided in or pursuant to this Indenture or unless the context
otherwise requires, for all purposes of this Indenture:

     (1) the terms defined in this Article One have the meanings assigned to them in this Article
One, and include the plural as well as the singular;

     (2) all other terms used herein which are defined in the Trust Indenture Act, either directly
or by reference therein, have the meanings assigned to them therein;

     (3) all accounting terms not otherwise defined herein have the meanings assigned to them in
accordance with generally accepted accounting principles and, except as otherwise herein expressly
provided, the terms “generally accepted accounting principles” or “GAAP” with respect to any
computation required or permitted hereunder shall mean such accounting principles as are generally
accepted as of the date hereof;

     (4) the words “herein,” “hereof,” “hereto” and “hereunder” and other words of similar import
refer to this Indenture as a whole and not to any particular Article, Section or other subdivision;

 

 

     (5) the word “or” is always used inclusively (for example, the phrase “A or B” means “A or B
or both,” not “either A or B but not both”);

     (6) provisions apply to successive events and transactions;

     (7) any reference to gender includes the masculine, feminine and the neuter, as the case may
be;

     (8) references to agreements and other instruments include subsequent amendments thereto and
restatements thereof;

     (9) “including” means “including without limitation”;

     (10) all exhibits are incorporated by reference herein and expressly made a part of this
Indenture;

     (11) all references to articles, sections and exhibits (and subparts thereof) are to this
Indenture; and

     (12) any transaction or event shall be considered “permitted by” or made “in accordance with”
or “in compliance with” this Indenture or any particular provision thereof if such transaction or
event is not expressly prohibited by this Indenture or such provision, as the case may be.

     Certain terms used principally in certain Articles hereof are defined in those Articles.

     “Act,” when used with respect to any Holders, has the meaning specified in Section
104.

     “Additional Amounts” means any additional amounts which are required by this Indenture
or by any Security, under circumstances specified herein or therein, to be paid by the Company in
respect of certain taxes, assessments or other governmental charges imposed on Holders specified
therein and which are owing to such Holders.

     “Affiliate” of any specified Person means any other Person directly or indirectly
controlling or controlled by or under direct or indirect common control with such specified Person.
For the purposes of this definition, “control,” when used with respect to any specified Person,
means the power to direct the management and policies of such Person, directly or indirectly,
whether through the ownership of voting securities, by contract or otherwise; and the terms
“controlling” and “controlled” have the meanings correlative to the foregoing.

     “Applicable Procedures” means, with respect to any transfer or exchange of or for
beneficial interests in any Global Security, the rules and procedures of the Depositary that apply
to such transfer or exchange at the relevant time.

     “Authenticating Agent” means any Person authorized by the Trustee pursuant to Section
612 to act on behalf of the Trustee to authenticate Securities of one or more series.

2

 

     “Authorized Newspaper” means a newspaper, in an official language of the place of
publication or in the English language, customarily published on each day that is a Business Day in
the place of publication, whether or not published on days that are Legal Holidays in the place of
publication, and of general circulation in each place in connection with which the term is used or
in the financial community of each such place. Where successive publications are required to be
made in Authorized Newspapers, the successive publications may be made in the same or in different
newspapers in the same city meeting the foregoing requirements and in each case on any day that is
a Business Day in the place of publication. If it shall be impractical in the opinion of the
Trustee to make any publication of any notice required hereby in an Authorized Newspaper, any
publication or other notice in lieu thereof which is made or given with the approval of the Trustee
shall constitute a sufficient publication of such notice.

     “Board of Directors” means:

     (1) with respect to the Company, the board of directors of the Company or any committee of the
board of directors of the Company duly authorized to act generally or in any particular respect for
the Company under this Indenture;

     (2) with respect to any other corporation, the board of directors of the corporation or any
authorized committee thereof;

     (3) with respect to a limited liability company, the managing member or managing members of
such limited liability company or any authorized committee thereof;

     (4) with respect to a partnership, the board of directors of the general partner of the
partnership or any authorized committee thereof; and

     (5) with respect to any other Person, the board or committee of such Person serving a similar
function.

     “Board Resolution” means a copy of one or more resolutions (which may be standing
resolutions), certified by the Secretary or an Assistant Secretary of the Company to have been duly
adopted by the Board of Directors of the Company and to be in full force and effect on the date of
such certification, and delivered to the Trustee.

     “Business Day” means, unless otherwise specified with respect to any Securities
pursuant to Section 301, each day that is not a Saturday, Sunday or other day on which banking
institutions in New York, New York or another Place of Payment are authorized or required by law,
regulation or executive order to close.

     “Capital Stock” means:

     (1) in the case of a corporation, corporate stock;

     (2) in the case of an association or business entity, any and all shares, interests,
participations, rights or other equivalents (however designated) of corporate stock;

3

 

     (3) in the case of a partnership or limited liability company, partnership or membership
interests (whether general or limited); and

     (4) any other interest or participation that confers on a Person the right to receive a share
of the profits and losses of, or distributions of assets of, the issuing Person.

     “Commission” means the Securities and Exchange Commission, as from time to time
constituted, created under the Exchange Act or any successor agency.

     “Common Stock” includes any stock of any class of the Company which has no preference
in respect of dividends or of amounts payable in the event of any voluntary or involuntary
liquidation, dissolution or winding up of the Company.

     “Company” means the Person named as the “Company” in the first paragraph of this
Indenture until a successor Person shall have become such pursuant to the applicable provisions of
this Indenture, and thereafter “Company” shall mean such successor Person.

     “Company Request” and “Company Order” mean, respectively, a written request or
order, as the case may be, signed in the name of the Company by the Chairman of the Board of
Directors of the Company, a Vice Chairman, the President, a Vice President, the Treasurer, the
Assistant Treasurer, the Secretary or the Assistant Secretary or other person authorized by
resolution of the Board of Directors of the Company, and delivered to the Trustee.

     “Corporate Trust Office” means the designated office of the Trustee at which the
corporate trust business of the Trustee shall at any particular time be administered, which office
at the date of original execution of this Indenture is located at 601 Travis Street, 16th Floor,
Houston, Texas 77002, Attention: Corporate Finance.

     “Corporation” includes corporations and limited liability companies and, except for
purposes of Article Eight, associations, companies (other than limited liability companies) and
business trusts.

     “Currency” means, with respect to any payment, deposit or other transfer in respect of
the principal of or any premium or interest on or any Additional Amounts with respect to any
Security, Dollars or the Foreign Currency, as the case may be, in which such payment, deposit or
other transfer is required to be made by or pursuant to the terms hereof or such Security and, with
respect to any other payment, deposit or transfer pursuant to or contemplated by the terms hereof
or such Security, means Dollars.

     “CUSIP number” means the alphanumeric designation assigned to a Security by Standard &
Poor’s Corporation, CUSIP Service Bureau.

     “Defaulted Interest” has the meaning specified in Section 307.

     “Definitive Security” means a certificated Security registered in the name of the
Holder thereof (other than a Depositary or its nominee) issued under this Indenture pursuant to
Section 301 and Section 305.

4

 

     “Dollars” or “$” means a dollar or other equivalent unit of legal tender for
payment of public or private debts in the United States of America.

     “Event of Default” has the meaning specified in Section 501.

     “Exchange Act” means the Securities Exchange Act of 1934, as amended, or any successor
thereto, in each case as amended from time to time.

     “Foreign Currency” means any currency, currency unit or composite currency, including,
without limitation, the euro, issued by the government of one or more countries other than the
United States of America or by any recognized confederation or association of such governments.

     “GAAP” means generally accepted accounting principles in the United States, which are
in effect from time to time.

     “Global Security” means a Security issued under this Indenture in global form pursuant
to Section 301, bearing the legend set forth in Section 203 and deposited with, or on behalf of,
and registered in the name of, the Depositary or its nominee.

     “Government Obligations” means securities which are (i) direct obligations of the
United States of America or the other government or governments in the confederation which issued
the Foreign Currency in which the principal of or any premium or interest on any Security or any
Additional Amounts in respect thereof shall be payable, in each case where the payment or payments
thereunder are supported by the full faith and credit of the United States or such government or
governments or (ii) obligations of a Person controlled or supervised by and acting as an agency or
instrumentality of the United States of America or such other government or governments, in each
case where the timely payment or payments thereunder are unconditionally guaranteed as a full faith
and credit obligation by the United States of America or such other government or governments, and
which, in the case of (i) or (ii), are not callable or redeemable at the option of the issuer or
issuers thereof, and shall also include a Depositary receipt issued by a bank or trust company as
custodian with respect to any such Government Obligation or a specific payment of interest on or
principal of or other amount with respect to any such Government Obligation held by such custodian
for the account of the holder of a Depositary receipt, provided that (except as required by law)
such custodian is not authorized to make any deduction from the amount payable to the holder of
such Depositary receipt from any amount received by the custodian in respect of the Government
Obligation or the specific payment of interest on or principal of or other amount with respect to
the Government Obligation evidenced by such Depositary receipt.

     “Holder” means, in the case of any Registered Security, the Person in whose name such
Security is registered in the Security Register.

     “Indenture” means this instrument as it may from time to time be supplemented or
amended by one or more indentures supplemental hereto entered into pursuant to the applicable
provisions hereof and, with respect to any Security of any series, by the terms and provisions of
such Security established pursuant to Section 301 (as such terms and provisions may be amended

5

 

pursuant to the applicable provisions hereof); provided, however, that, if at any time more
than one Person is acting as Trustee under this instrument, “Indenture” shall mean, with respect to
any one or more series of Securities for which such Person is Trustee, this instrument as
originally executed or as it may from time to time be supplemented or amended by one or more
indentures supplemental hereto entered into pursuant to the applicable provisions hereof and shall
include the terms of those particular series of Securities for which such Person is Trustee
established pursuant to Section 301, exclusive, however, of any provisions or terms which relate
solely to other series of Securities for which such Person is not Trustee, regardless of when such
terms or provisions were adopted.

     “Independent Registered Public Accounting Firm” means a firm of accountants that, with
respect to the Company and any other obligor under the Securities, is an independent registered
public accounting firm within the meaning of the Securities Act of 1933, as amended, and the rules
and regulations promulgated by the Commission thereunder, who may be the independent registered
public accounting firm regularly retained by the Company or who may be another independent
registered public accounting firm. Such firm shall be entitled to rely upon any Opinion of Counsel
as to the interpretation of any legal matters relating to this Indenture or certificates required
to be provided hereunder.

     “Indexed Security” means a Security the terms of which provide that the principal
amount thereof payable at Stated Maturity may be more or less than the principal face amount
thereof at original issuance.

     “Indirect Participant” means an entity that, with respect to any Depositary, clears
through or maintains a direct or indirect, custodial relationship with a Participant.

     “interest” means any interest specified in any Security as being payable with respect
to that Security and, with respect to any Original Issue Discount Security which by its terms bears
interest only after Maturity, means interest payable after Maturity and, when used with respect to
a Security which provides for the payment of Additional Amounts pursuant to Section 1004, includes
such Additional Amounts.

     “Interest Payment Date” means, with respect to any Security, the Stated Maturity of an
installment of interest on such Security.

     “Joint Venture” means any Person that is not a direct or indirect Subsidiary of the
Company in which the Company or any of its Subsidiaries owns any Capital Stock.

     “Judgment Currency” has the meaning specified in Section 116.

     “Legal Holidays” has the meaning specified in Section 114.

     “Maturity” means, with respect to any Security, the date on which the principal of
such Security or an installment of principal becomes due and payable as provided in or pursuant to
this Indenture, whether at the Stated Maturity or by declaration of acceleration, notice of
redemption or repurchase, notice of option to elect repayment or otherwise, and includes the
Redemption Date.

6

 

     “New York Banking Day” has the meaning specified in Section 116.

     “Office” or “Agency,” means, with respect to any Securities, an office or
agency of the Company maintained or designated in a Place of Payment for such Securities pursuant
to Section 1002 or any other office or agency of the Company maintained or designated for such
Securities pursuant to Section 1002 or, to the extent designated or required by Section 1002 in
lieu of such office or agency, the Corporate Trust Office of the Trustee.

     “Officer” means, with respect to any Person, the Chairman of the Board of Directors, a
Vice Chairman, the Chief Executive Officer, the President, any Vice President (without regard to
qualifiers such as “Executive” or “Senior”), the Chief Operating Officer, the Chief Financial
Officer, the Treasurer, an Assistant Treasurer, the Controller, the Secretary or an Assistant
Secretary of such Person, or other Person authorized by resolution of the Board of Directors of the
Company.

     “Officer’s Certificate” means a certificate signed by an Officer, that, if applicable,
complies with the requirements of Section 314(e) of the Trust Indenture Act and is delivered to the
Trustee.

     “Opinion of Counsel” means a written opinion of counsel, who may be an employee of or
counsel for the Company or other counsel that, if applicable, complies with the requirements of
Section 314(e) of the Trust Indenture Act.

     “Original Issue Discount Security” means a Security issued pursuant to this Indenture
which provides, at any time prior to the final Stated Maturity of such Security, for declaration of
an amount less than the principal amount thereof to be due and payable upon acceleration pursuant
to Section 502.

     “Outstanding” means, when used with respect to any Securities, as of the date of
determination, all such Securities theretofore authenticated and delivered under this Indenture,
except:

     (1) any such Security theretofore cancelled by the Trustee or delivered to the Trustee for
cancellation including Securities tendered and exchanged for other securities of the Company;

     (2) any such Security of any series for which payment at the Maturity thereof money in the
necessary amount has been theretofore deposited pursuant hereto (other than pursuant to Section
402) with the Trustee or any Paying Agent (other than the Company) in trust or set aside and
segregated in trust by the Company (if the Company shall act as its own Paying Agent) for the
Holders of such series of Securities, provided that, if such Securities are to be redeemed, notice
of such redemption has been duly given pursuant to this Indenture or provision therefor
satisfactory to the Trustee has been made;

     (3) any such Security of any series with respect to which the Company has effected defeasance
or covenant defeasance pursuant to the terms hereof, except to the extent provided in Section 402;

7

 

     (4) any such Security which has been paid pursuant to Section 306 or in exchange for or in
lieu of which other Securities have been authenticated and delivered pursuant to this Indenture,
unless there shall have been presented to the Trustee proof satisfactory to it that such Security
is held by a “protected purchaser” (as such term is defined in the New York Uniform Commercial
Code) in whose hands such Security is a valid obligation of the Company; and

     (5) any such Security converted or exchanged as contemplated by this Indenture into Common
Stock or other securities, cash or other property, if the terms of such Security provide for such
conversion or exchange pursuant to Section 301;

provided, however, that in determining whether the Holders of the requisite principal amount of
Outstanding Securities of any series have given any request, demand, authorization, direction,
notice, consent or waiver hereunder or are present at a meeting of Holders of Securities of such
series for quorum purposes, (i) the principal amount of an Original Issue Discount Security that
may be counted in making such determination and that shall be deemed to be Outstanding for such
purposes shall be equal to the amount of the principal thereof that pursuant to the terms of such
Original Issue Discount Security would be declared (or shall have been declared to be) due and
payable upon a declaration of acceleration thereof pursuant to Section 502 at the time of such
determination, and (ii) the principal amount of any Indexed Security that may be counted in making
such determination and that shall be deemed Outstanding for such purpose shall be equal to the
principal face amount of such Indexed Security at original issuance, unless otherwise provided in
or pursuant to this Indenture, and (iii) the principal amount of a Security denominated in a
Foreign Currency shall be the Dollar equivalent, determined on the date of original issuance of
such Security, of the principal amount (or, in the case of an Original Issue Discount Security, the
Dollar equivalent on the date of original issuance of such Security of the amount determined as
provided in (i) above) of such Security, and (iv) Securities owned by the Company or any other
obligor upon the Securities or any Affiliate of the Company or such other obligor, shall be
disregarded and deemed not to be Outstanding, except that, in determining whether the Trustee shall
be protected in making any such determination or relying upon any such request, demand,
authorization, direction, notice, consent or waiver, only Securities which a Responsible Officer
actually knows to be so owned shall be so disregarded. Securities so owned which shall have been
pledged in good faith may be regarded as Outstanding if the pledgee establishes to the satisfaction
of a Responsible Officer (A) the pledgee’s right so to act with respect to such Securities and (B)
that the pledgee is not the Company or any other obligor upon the Securities or an Affiliate of the
Company or such other obligor.

     “Participant” means, with respect to the Depositary, a Person who has an account with
the Depositary.

     “Paying Agent” means any Person authorized by the Company to pay the principal of, or
any premium or interest on, or any Additional Amounts with respect to, any Security on behalf of
the Company.

     “Person” or “person” means any individual, corporation, partnership, joint
venture, joint-stock company, association, trust, unincorporated organization, limited liability
company or government or any agency or political subdivision thereof.

8

 

     “Place of Payment” means, with respect to any Security, the place or places where the
principal of, or any premium or interest on, or any Additional Amounts with respect to such
Security are payable as provided in or pursuant to this Indenture or such Security.

     “Predecessor Security” of any particular Security means every previous Security
evidencing all or a portion of the same indebtedness as that evidenced by such particular Security;
and, for the purposes of this definition, any Security authenticated and delivered under Section
306 in exchange for or in lieu of a lost, destroyed, mutilated or stolen Security shall be deemed
to evidence the same indebtedness as the lost, destroyed, mutilated or stolen Security.

     “Redemption Date” means, with respect to any Security or portion thereof to be
redeemed, each date fixed for such redemption by or pursuant to this Indenture or such Security.

     “Redemption Price” means, with respect to any Security or portion thereof to be
redeemed, the price at which it is to be redeemed including, if applicable, accrued and unpaid
interest and Additional Amounts as determined by or pursuant to this Indenture or such Security.

     “Registered Security” means any Security established pursuant to Section 201 which is
registered in the Security Register.

     “Regular Record Date” for the interest payable on any Registered Security on any
Interest Payment Date therefor means the date, if any, specified in or pursuant to this Indenture
or such Security as the “Regular Record Date.”

     “Required Currency” has the meaning specified in Section 116.

     “Responsible Officer” means any officer of the Trustee in its Corporate Trust Office
with direct responsibility for the administration of this Indenture, and also, with respect to a
particular corporate trust matter, any other officer of the Trustee to whom such matter is referred
because of such officer’s knowledge of and familiarity with the particular subject.

     “Security” or “Securities” means any note or notes, bond or bonds, debenture
or debentures, or any other evidences of indebtedness, as the case may be, authenticated and
delivered under this Indenture; provided, however, that, if at any time there is more than one
Person acting as Trustee under this Indenture, “Securities,” with respect to any such Person, shall
mean Securities authenticated and delivered under this Indenture, exclusive, however, of Securities
of any series as to which such Person is not Trustee.

     “Security Register,” “Security Registrar” and “Registrar” have the
respective meanings specified in Section 305.

     “series” means a series of Securities established under this Indenture.

     “Special Record Date” for the payment of any Defaulted Interest on any Registered
Security means a date fixed by the Trustee pursuant to Section 307.

     “Stated Maturity” means, with respect to any Security or any installment of principal
thereof or interest thereon or any Additional Amounts with respect thereto, the date established

9

 

by or pursuant to this Indenture or such Security as the fixed date on which the principal of
such Security or such installment of principal or interest is, or such Additional Amounts are, due
and payable.

     “Subsidiary” means, with respect to any specified Person:

     (1) any corporation, association or other business entity (other than a partnership or limited
liability company) of which more than 50% of the total voting power of Voting Stock is at the time
owned or controlled, directly or indirectly, by that Person or one or more of the other
Subsidiaries of that Person (or a combination thereof); and

     (2) any partnership (whether general or limited) or limited liability company (a) the sole
general partner or member of which is such Person or a Subsidiary of such Person, or (b) if there
is more than a single general partner or member, either (x) the only managing general partners or
managing members of which are such Person or one or more Subsidiaries of such Person (or any
combination thereof) or (y) such Person owns or controls, directly or indirectly, a majority of the
outstanding general partner interests, member interests or other Voting Stock of such partnership
or limited liability company, respectively.

     “Trust Indenture Act” or “TIA” means the Trust Indenture Act of 1939, as
amended, and any reference herein to the Trust Indenture Act or a particular provision thereof
shall mean such Act or provision, as the case may be, as amended or replaced from time to time or
as supplemented from time to time by rules or regulations adopted by the Commission under or in
furtherance of the purposes of such Act or provision, as the case may be.

     “Trustee” means the Person named as the “Trustee” in the first paragraph of this
instrument until a successor Trustee shall have become such with respect to one or more series of
Securities pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall
mean each Person who is then a Trustee hereunder; provided, however, that if at any time there is
more than one such Person, “Trustee” shall mean each such Person and as used with respect to the
Securities of any series shall mean only the Trustee with respect to the Securities of such series.

     “United States” means, except as otherwise provided in or pursuant to this Indenture
or any Security, the United States of America (including the states thereof and the District of
Columbia), its territories and possessions and other areas subject to its jurisdiction.

     “United States Alien” means, except as otherwise provided in or pursuant to this
Indenture or any Security, any Person who, for United States federal income tax purposes, is a
foreign corporation, a non-resident alien individual, a non-resident alien fiduciary of a foreign
estate or trust, or a foreign partnership one or more of the members of which is, for United States
federal income tax purposes, a foreign corporation, a non-resident alien individual or a
non-resident alien fiduciary of a foreign estate or trust.

     “U.S. Depositary” or “Depositary” means, with respect to any Security issuable
or issued in the form of one or more Global Securities, the Person designated as U.S. Depositary or
Depositary by the Company in or pursuant to this Indenture, which Person must be, to the extent

10

 

required by applicable law or regulation, a clearing agency registered under the Exchange Act
and, if so provided with respect to any Security, any successor to such Person. If at any time
there is more than one such Person, “U.S. Depositary” or “Depositary” shall mean, with respect to
any Securities, the qualifying entity which has been appointed with respect to such Securities.

     “Vice President” means, when used with respect to the Company or the Trustee, any vice
president, whether or not designated by a number or a word or words added before or after the title
“Vice President.”

     “Voting Stock” of any Person as of any date means the Capital Stock of such Person
that is at the time entitled (without regard to the occurrence of any contingency) to vote in the
election of the Board of Directors of such Person.

Section 102 Compliance Certificates and Opinions.

     Except as otherwise expressly provided in or pursuant to this Indenture, upon any application
or request by the Company to the Trustee to take any action under any provision of this Indenture,
the Company shall furnish to the Trustee an Officer’s Certificate stating that all conditions
precedent, if any, provided for in this Indenture relating to the proposed action have been
complied with and an Opinion of Counsel stating that, in the opinion of such counsel, all such
conditions precedent, if any, have been complied with, except that in the case of any such
application or request as to which the furnishing of such documents or any of them is specifically
required by any provision of this Indenture relating to such particular application or request, no
additional certificate or opinion need be furnished.

     Every certificate or opinion with respect to compliance with a condition or covenant or
covenant provided for in this Indenture (other than a certificate delivered pursuant to Section
1006) shall include:

     (1) a statement that each individual signing such certificate or opinion has read such
condition or covenant and the definitions herein relating thereto;

     (2) a brief statement as to the nature and scope of the examination or investigation upon
which the statements or opinions contained in such certificate or opinion are based;

     (3) a statement that, in the opinion of each such individual, he has made such examination or
investigation as is necessary to enable him to express an informed opinion as to whether or not
such condition or covenant has been complied with; and

     (4) a statement as to whether, in the opinion of each such individual, such condition or
covenant has been complied with.

Section 103 Form of Documents Delivered to Trustee.

     In any case where several matters are required to be certified by, or covered by an opinion
of, any specified Person, it is not necessary that all such matters be certified by, or covered by
the opinion of, only one such Person, or that they be so certified or covered by only one document,
but one such Person may certify or give an opinion with respect to some matters

11

 

and one or more other such Persons as to other matters, and any such Person may certify or
give an opinion as to such matters in one or several documents.

     Any certificate or opinion of an Officer of the Company may be based, insofar as it relates to
legal matters, upon an Opinion of Counsel, unless such Officer knows that the opinion with respect
to the matters upon which his certificate or opinion is based are erroneous. Any such Opinion of
Counsel may be based, insofar as it relates to factual matters, upon a certificate or opinion of,
or representations by, an Officer or Officers of the Company stating that the information with
respect to such factual matters is in the possession of the Company unless such counsel knows that
the certificate or opinion or representations with respect to such matters are erroneous. Any
certificate, statement or opinion of an Officer of the Company or any Opinion of Counsel may be
based, insofar as it relates to accounting matters, upon a certificate or opinion of or
representations by an accountant or firm of accountants in the employ of the Company, unless such
Officer or counsel, as the case may be, knows that the certificate or opinion or representations
with respect to the accounting matters upon which his certificate, statement or opinion may be
based as aforesaid are erroneous.

     Where any Person is required to make, give or execute two or more applications, requests,
consents, certificates, statements, opinions or other instruments under this Indenture or any
Security, they may, but need not, be consolidated and form one instrument.

Section 104 Acts of Holders.

     (1) Any request, demand, authorization, direction, notice, consent, waiver or other action
provided by or pursuant to this Indenture to be given or taken by Holders may be embodied in and
evidenced by one or more instruments (including instruments in electronic, digital or other
machine-readable form) of substantially similar tenor signed by such Holders (whether in person or
through signatures in electronic, digital or other machine-readable form) or by an agent duly
appointed in writing (including writings in electronic, digital or other machine-readable form) or
may be embodied in and evidenced by the record of Holders voting in favor thereof, either in person
or by proxies duly appointed in writing, at any meeting of Holders duly called and held in
accordance with the provisions of Article Fifteen, or a combination of such instruments or record.
Except as herein otherwise expressly provided, such action shall become effective when such
instrument or instruments or record or both are delivered to the Trustee and, where it is hereby
expressly required, to the Company. Such instrument or instruments or record or both (and the
action embodied therein and evidenced thereby) are herein sometimes referred to as the
“Act” of the Holders signing such instrument or instruments or so voting at any such
meeting. Proof of execution of any such instrument or of a writing appointing any such agent, or
of the holding by any Person of a Security, shall be sufficient for any purpose of this Indenture
and (subject to Section 315 of the Trust Indenture Act) conclusive in favor of the Trustee and the
Company and any agent of the Trustee or the Company, if made in the manner provided in this Section
104. The record of any meeting of Holders of Securities shall be proved in the manner provided in
Section 1506.

     Without limiting the generality of this Section 104, unless otherwise provided in or pursuant
to this Indenture, a Holder, including a U.S. Depositary that is a Holder of a Global Security, may
make, give or take, by a proxy or proxies, duly appointed in writing, any request,

12

 

demand, authorization, direction, notice, consent, waiver or other Act provided in or pursuant
to this Indenture or the Securities to be made, given or taken by Holders, and a U.S. Depositary
that is a Holder of a Global Security may provide its proxy or proxies to the beneficial owners of
interests in any such Global Security through such U.S. Depositary’s standing instructions and
customary practices.

     The Trustee may fix a record date for the purpose of determining the Persons who are
beneficial owners of interests in any permanent Global Security held by a U.S. Depositary entitled
under the procedures of such U.S. Depositary to make, give or take, by a proxy or proxies duly
appointed in writing, any request, demand, authorization, direction, notice, consent, waiver or
other Act provided in or pursuant to this Indenture to be made, given or taken by Holders.

     (2) The fact and date of the execution by any Person of any such instrument or writing
referred to in this Section 104 may be proved in any reasonable manner which the Trustee deems
sufficient and in accordance with such reasonable rules as the Trustee may determine; and the
Trustee may in any instance require further proof with respect to any of the matters referred to in
this Section 104.

     (3) The ownership, principal amount and serial numbers of Registered Securities held by any
Person, and the date of the commencement and the date of the termination of holding the same, shall
be proved by the Security Register.

     (4) If the Company shall solicit from the Holders of any Registered Securities any request,
demand, authorization, direction, notice, consent, waiver or other Act, the Company may at its
option (but is not obligated to), by Board Resolution, fix in advance a record date for the
determination of Holders of Registered Securities entitled to give such request, demand,
authorization, direction, notice, consent, waiver or other Act. If such a record date is fixed,
such request, demand, authorization, direction, notice, consent, waiver or other Act may be given
before or after such record date, but only the Holders of Registered Securities of record at the
close of business on such record date shall be deemed to be Holders for the purpose of determining
whether Holders of the requisite proportion of Outstanding Securities have authorized or agreed or
consented to such request, demand, authorization, direction, notice, consent, waiver or other Act,
and for that purpose the Outstanding Securities shall be computed as of such record date; provided
that no such authorization, agreement or consent by the Holders of Registered Securities shall be
deemed effective unless it shall become effective pursuant to the provisions of this Indenture not
later than six months after the record date.

     (5) Any request, demand, authorization, direction, notice, consent, waiver or other Act by the
Holder of any Security shall bind every future Holder of the same Security and the Holder of every
Security issued upon the registration of transfer thereof or in exchange therefor or in lieu
thereof in respect of anything done or suffered to be done by the Trustee, any Security Registrar,
any Paying Agent or the Company in reliance thereon, whether or not notation of such Act is made
upon such Security.

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Section 105 Notices, etc. to Trustee and Company.

     Any request, demand, authorization, direction, notice, consent, waiver or other Act of Holders
or other document provided or permitted by this Indenture to be made upon, given or furnished to,
or filed with,

     (1) the Trustee by any Holder or the Company shall be sufficient for every purpose hereunder
if made, given, furnished or filed in writing (which may be via facsimile) to or with the Trustee
at its Corporate Trust Office, or

     (2) the Company by the Trustee or any Holder shall be sufficient for every purpose hereunder
(unless otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid
or airmail postage prepaid if sent from outside the United States, to the Company addressed to the
attention of its Treasurer (with a copy to the General Counsel) at the address of its principal
office specified in the first paragraph of this instrument or at any other address previously
furnished in writing to the Trustee by the Company.

Section 106 Notice to Holders of Securities; Waiver.

     Except as otherwise expressly provided in or pursuant to this Indenture, where this Indenture
provides for notice to Holders of Securities of all or any series of any event, such notice shall
be sufficiently given to Holders of Registered Securities of such series if in writing and mailed,
first-class postage prepaid, to each Holder of a Registered Security affected by such event, at his
address as it appears in the Security Register, not later than the latest date, and not earlier
than the earliest date, prescribed for the giving of such notice. In any case where notice to
Holders of Registered Securities is given by mail, neither the failure to mail such notice, nor any
defect in any notice so mailed, to any particular Holder of a Registered Security shall affect the
sufficiency of such notice with respect to other Holders of Registered Securities given as provided
herein. Any notice which is mailed in the manner herein provided shall be conclusively presumed to
have been duly given or provided. In the case by reason of the suspension of regular mail service
or by reason of any other cause it shall be impracticable to give such notice by mail, then such
notification as shall be made with the approval of the Trustee shall constitute a sufficient
notification for every purpose hereunder.

     Where this Indenture provides for notice in any manner, such notice may be waived in writing
by the Person entitled to receive such notice, either before or after the event, and such waiver
shall be the equivalent of such notice. Waivers of notice by Holders of Securities shall be filed
with the Trustee, but such filing shall not be a condition precedent to the validity of any action
taken in reliance upon such waiver.

Section 107 Language of Notices.

     Any request, demand, authorization, direction, notice, consent, election or waiver required or
permitted under this Indenture shall be in the English language, except that, if the Company so
elects, any published notice may be in an official language of the country of publication (with a
copy in English to be provided to the Trustee).

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Section 108 Incorporation by Reference of Trust Indenture Act; Trust Indenture Act Controls.

     (a) If any provision hereof limits, qualifies or conflicts with the duties that would be
imposed by any of Sections 310 to 317 of the Trust Indenture Act through operation of Section
318(c) thereof on any person, such imposed duties shall control. The following Trust Indenture Act
terms have the following meanings:

          “indenture securities” means the Securities;

          “indenture security holder” means a Holder;

          “indenture to be qualified” means this Indenture;

          “indenture trustee” or “institutional trustee” means the Trustee; and

          “obligor” on the indenture securities means the Company and any other obligor on the indenture
securities.

          All other Trust Indenture Act terms used in this Indenture that are defined by the Trust
Indenture Act, defined in the Trust Indenture Act by reference to another statute or defined by SEC
Rule have the meanings assigned to them by such definitions.

     (b) If any provision of this Indenture limits, qualifies or conflicts with another provision
which is required to be included in this Indenture by the Trust Indenture Act, the provision
required by the Trust Indenture Act shall control.

Section 109 Effect of Headings and Table of Contents.

     The Article and Section headings herein and the Table of Contents are for convenience only and
shall not affect the construction hereof.

Section 110 Successors and Assigns.

     All covenants and agreements in this Indenture by the Company shall bind its successors and
assigns, whether so expressed or not.

Section 111 Separability Clause.

     In case any provision in this Indenture or any Security shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining provisions shall not in
any way be affected or impaired thereby.

Section 112 Benefits of Indenture.

     Nothing in this Indenture or any Security, express or implied, shall give to any Person, other
than the parties hereto, any Security Registrar, any Paying Agent, any Authentication
Agent and their successors hereunder and the Holders of Securities, any benefit or any legal
or equitable right, remedy or claim under this Indenture.

15

 

Section 113 Governing Law; Waiver of Trial by Jury.

     This Indenture and the Securities shall be governed by and construed in accordance with the
laws of the State of New York applicable to agreements made or instruments entered into and, in
each case, performed in said state. Each of the Company and the Trustee hereby irrevocably waives,
to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal
proceeding arising out of or relating to this Indenture, the Securities or the transactions
contemplated hereby.

Section 114 Legal Holidays.

     Unless otherwise specified in or pursuant to this Indenture or any Securities, in any case
where any Interest Payment Date, Stated Maturity or Maturity of any Security, or the last date on
which a Holder has the right to convert or exchange Securities of a series that are convertible or
exchangeable shall not be a Business Day (a “Legal Holiday”) at any Place of Payment, then
(notwithstanding any other provision of this Indenture or any Security other than a provision in
any Security that specifically states that such provision shall apply in lieu hereof) payment need
not be made at such Place of Payment on such date, and such Securities need not be converted or
exchanged on such date but such payment may be made, and such Securities may be converted or
exchanged, on the next succeeding day that is a Business Day at such Place of Payment with the same
force and effect as if made on the Interest Payment Date or at the Stated Maturity or Maturity or
on such last day for conversion or exchange, and no interest shall accrue on the amount payable on
such date or at such time for the period from and after such Interest Payment Date, Stated
Maturity, Maturity or last day for conversion or exchange, as the case may be, to the next
succeeding Business Day. If this Indenture provides for a time period that ends or requires
performance of any non-payment obligation by a day that is not a Business Day, then such time
period shall instead be deemed to end on, and such obligation shall instead be performed by, the
next succeeding Business Day.

Section 115 Counterparts.

     This Indenture may be executed in several counterparts, each of which shall be an original and
all of which shall constitute but one and the same instrument.

Section 116 Judgment Currency.

     The Company agrees, to the fullest extent that it may effectively do so under applicable law,
that (a) if for the purpose of obtaining judgment in any court it is necessary to convert the sum
due in respect of the principal of, or premium or interest, if any, or Additional Amounts on the
Securities of any series (the “Required Currency”) into a currency in which a judgment will
be rendered (the “Judgment Currency”), the rate of exchange used shall be the rate at which
in accordance with normal banking procedures the Trustee could purchase in The City of New York the
requisite amount of the Required Currency with the Judgment Currency on the New York Banking Day
preceding the day on which a final unappealable judgment is given and (b) its
obligations under this Indenture to make payments in the Required Currency (i) shall not be
discharged or satisfied by any tender, or any recovery pursuant to any judgment (whether or not
entered in accordance with clause (a)), in any currency other than the Required Currency, except

16

 

to
the extent that such tender or recovery shall result in the actual receipt, by the payee, of the
full amount of the Required Currency expressed to be payable in respect of such payments, (ii)
shall be enforceable as an alternative or additional cause of action for the purpose of recovering
in the Required Currency the amount, if any, by which such actual receipt shall fall short of the
full amount of the Required Currency so expressed to be payable and (iii) shall not be affected by
judgment being obtained for any other sum due under this Indenture. For purposes of the foregoing,
“New York Banking Day” means any day except a Saturday, Sunday or a Legal Holiday in The
City of New York or a day on which banking institutions in The City of New York are authorized or
obligated by law, regulation or executive order to be closed.

Section 117 Limitation on Individual Liability.

     No recourse under or upon any obligation, covenant or agreement contained in this Indenture or
in any Security, or for any claim based thereon or otherwise in respect thereof, shall be had
against any incorporator, shareholder, officer or director, as such, past, present or future, of
the Company or of any successor, either directly or through the Company or any successor, whether
by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or
penalty or otherwise; it being expressly understood that this Indenture and the obligations issued
hereunder are solely corporate obligations, and that no such personal liability whatever shall
attach to, or is or shall be incurred by, the incorporators, shareholders, officers or directors,
as such, of the Company or any successor, or any of them, because of the creation of the
indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements
contained in this Indenture or in any Security or implied therefrom; and that any and all such
personal liability of every name and nature, either at common law or in equity or by constitution
or statute, of, and any and all such rights and claims against, every such incorporator,
shareholder, officer or director, as such, because of the creation of the indebtedness hereby
authorized, or under or by reason of the obligations, covenants or agreements contained in this
Indenture or in any Security or implied therefrom, are hereby expressly waived and released as a
condition of, and as a consideration for, the execution of this Indenture and the issuance of such
Security.

ARTICLE TWO

SECURITIES FORMS

Section 201 Forms Generally.

     Each Registered Security and temporary or permanent Global Security or Definitive Security
issued pursuant to this Indenture shall be in the form established by or pursuant to a Board
Resolution and set forth in an Officer’s Certificate, or established in one or more indentures
supplemental hereto, shall have such appropriate insertions, omissions, substitutions and other
variations as are required or permitted by or pursuant to this Indenture or any indenture
supplemental hereto and may have such letters, numbers or other marks of identification and
such legends or endorsements placed thereon as may, consistently herewith, be determined by
the Officers executing such Security as evidenced by their execution of such Security.

17

 

     Unless otherwise provided in or pursuant to this Indenture or any Securities, the Securities
shall be issuable in registered form without coupons and shall not be issuable upon the exercise of
warrants.

     Definitive Securities shall be printed, lithographed or engraved or produced by any
combination of these methods on a steel engraved border or steel engraved borders or may be
produced in any other manner, all as determined by the Officers of the Company executing such
Securities, as evidenced by their execution of such Securities.

Section 202 Form of Trustee’s Certificate of Authentication.

     Subject to Section 612, the Trustee’s certificate of authentication shall be in substantially
the following form:

     This is one of the Securities of the series designated therein referred to in the
within-mentioned Indenture.

	 	 	 	 	 
	 	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.,
as Trustee

 	 
	 	By  	
 	 
	 	 	Authorized Signatory 

	 
	 	Dated:
	 
	 

Section 203 Securities in Global Form.

     Unless otherwise provided in or pursuant to this Indenture or any Securities, the Securities
shall be issuable in permanent global form. If Securities of a series shall be issuable in global
form, any such Security may provide that it or any number of such Securities shall represent the
aggregate amount of all Outstanding Securities of such series (or such lesser amount as is
permitted by the terms thereof) from time to time endorsed thereon and may also provide that the
aggregate amount of Outstanding Securities represented thereby may from time to time be increased
or reduced to reflect exchanges, redemptions or transfer of beneficial interests from one Global
Security to another Global Security. Any endorsement of any Global Security to reflect the amount,
or any increase or decrease in the amount, or changes in the rights of Holders, of Outstanding
Securities represented thereby shall be made in such manner and by such Person or Persons as shall
be specified therein or in the Company Order to be delivered pursuant to Section 303 or Section 304
with respect thereto. Subject to the provisions of Section 303 and, if applicable, Section 304,
the Trustee shall deliver and redeliver any Security in permanent global form in the manner and
upon instructions given by the Person or Persons specified therein or in the applicable Company
Order. If a Company Order pursuant to Section 303 or Section 304 has been, or simultaneously is,
delivered, any instructions by the Company
with respect to a Global Security shall be in writing but need not be accompanied by or
contained in an Officer’s Certificate and need not be accompanied by an Opinion of Counsel.

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     Notwithstanding the provisions of Section 307, unless otherwise specified in or pursuant to
this Indenture or any Securities, payment of principal of, any premium and interest on, and any
Additional Amounts in respect of, any Security in temporary or permanent global form shall be made
to the Person or Persons specified therein.

     Notwithstanding the provisions of Section 308 and except as provided in the preceding
paragraph, the Company, the Trustee and any agent of the Company or the Trustee shall treat as the
Holder of such principal amount of Outstanding Securities as is represented by a Global Security in
the case of a Global Security in registered form, the Holder of such Global Security in registered
form.

     Each Global Security shall bear a legend in substantially the following form (unless otherwise
specified by the Depositary):

     “THIS DEBT SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER
REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS DEBT SECURITY
MAY NOT BE TRANSFERRED TO, OR REGISTERED OR EXCHANGED FOR SECURITIES REGISTERED IN THE NAME OF, ANY
PERSON OTHER THAN THE DEPOSITARY OR A NOMINEE THEREOF AND NO SUCH TRANSFER MAY BE REGISTERED,
EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. EVERY DEBT SECURITY AUTHENTICATED
AND DELIVERED UPON REGISTRATION OF TRANSFER OF, OR IN EXCHANGE FOR OR IN LIEU OF, THIS DEBT
SECURITY SHALL BE A GLOBAL SECURITY SUBJECT TO THE FOREGOING, EXCEPT IN SUCH LIMITED
CIRCUMSTANCES.”

ARTICLE THREE

THE SECURITIES

Section 301 Amount Unlimited; Issuable in Series.

     The aggregate principal amount of Securities which may be authenticated and delivered under
this Indenture is unlimited. The Securities may be issued in one or more series. With respect to
any Securities to be authenticated and delivered hereunder, there shall be established in or
pursuant to a Board Resolution and set forth in an Officer’s Certificate, or established in one or
more indentures supplemental hereto,

     (1) the title of such Securities and the series, including CUSIP numbers in which such
Securities shall be included;

     (2) any limit upon the aggregate principal amount of the Securities of such series which may
be authenticated and delivered under this Indenture (except for Securities authenticated and
delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities of
such series pursuant to Section 304, Section 305, Section 306, Section 906 or Section 1107, upon
repayment in part of any Registered Security of such series pursuant to Article Thirteen or
upon surrender in part of any Registered Security for conversion or exchange into Common Stock or

19

 

other securities, cash or other property pursuant to its terms, or pursuant to the terms of such
Securities and except for any Securities, which, pursuant to Section 303, are deemed never to have
been authenticated and delivered hereunder);

     (3) if any of such Securities are to be issuable in global form, when any of such Securities
are to be issuable in global form and (i) whether such Securities are to be issued in temporary or
permanent global form or both, (ii) whether beneficial owners of interests in any such Global
Security may exchange such interests for Securities of the same series and of like tenor and of any
authorized form and denomination, and the circumstances under which any such exchanges may occur,
if other than in the manner specified in Section 305, and (iii) the name of the Depositary or the
U.S. Depositary, as the case may be, with respect to any Global Security;

     (4) the date as of which any Global Security shall be dated (if other than the date of
original issuance of the first of such Securities to be issued);

     (5) the date or dates, or the method or methods, if any, by which such date or dates shall be
determined, on which the principal and premium, if any, of such Securities is payable;

     (6) the rate or rates at which such Securities shall bear interest, if any, or the method or
methods, if any, by which such rate or rates are to be determined, the date or dates, if any, from
which such interest shall accrue or the method or methods, if any, by which such date or dates are
to be determined, the Interest Payment Dates, if any, on which such interest shall be payable and
the Regular Record Date, if any, for the interest payable on Registered Securities on any Interest
Payment Date, whether and under what circumstances Additional Amounts on such Securities or any of
them shall be payable, the notice, if any, to Holders regarding the determination of interest on a
floating rate Security and the manner of giving such notice, and the basis upon which interest
shall be calculated if other than that of a 360-day year of twelve 30- day months;

     (7) if in addition to or other than the Borough of Manhattan, The City of New York, the place
or places where the principal of, any premium and interest on or any Additional Amounts with
respect to such Securities shall be payable, any of such Securities that are Registered Securities
may be surrendered for registration of transfer or exchange, any of such Securities may be
surrendered for conversion or exchange and notices or demands to or upon the Company in respect of
such Securities and this Indenture may be served, the extent to which, or the manner in which, any
interest payment or Additional Amounts on a Global Security on an Interest Payment Date, will be
paid and the manner in which any principal of or premium, if any, on any Global Security will be
paid;

     (8) whether any of such Securities are to be redeemable at the option of the Company and, if
so, the date or dates on which, the period or periods within which, the price or prices at which
and the other terms and conditions upon which such Securities may be redeemed, in whole or in part,
at the option of the Company;

     (9) whether the Company is obligated to redeem or purchase any of such Securities pursuant to
any sinking fund or analogous provision or at the option of any Holder thereof and, if so, the date
or dates on which, the period or periods within which, the price or prices at which

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and the other
terms and conditions upon which such Securities shall be redeemed or purchased, in whole or in
part, pursuant to such obligation, and any provisions for the remarketing of such Securities so
redeemed or purchased;

     (10) the denominations in which any of such Securities that are Registered Securities shall be
issuable if other than denominations of $2,000 and any multiple of $1,000 in excess thereof;

     (11) whether the Securities of the series will be convertible into shares of Common Stock
and/or exchangeable for other securities, cash or other property of the Company or of any other
Person, and if so, the terms and conditions upon which such Securities will be so convertible or
exchangeable, and any deletions from or modifications or additions to this Indenture to permit or
to facilitate the issuance of such convertible or exchangeable Securities or the administration
thereof;

     (12) if other than the principal amount thereof, the portion of the principal amount of any of
such Securities that shall be payable upon declaration of acceleration of the Maturity thereof
pursuant to Section 502 or the method by which such portion is to be determined;

     (13) if other than Dollars, the Foreign Currency in which payment of the principal of, any
premium or interest on or any Additional Amounts with respect to any of such Securities shall be
payable;

     (14) if the principal of, any premium or interest on or any Additional Amounts with respect to
any of such Securities are to be payable, at the election of the Company or a Holder thereof or
otherwise, in Currency other than that in which such Securities are stated to be payable, the date
or dates on which, the period or periods within which, and the other terms and conditions upon
which, such election may be made, and the time and manner of determining the exchange rate between
the Currency in which such Securities are stated to be payable and the Currency in which such
Securities or any of them are to be paid pursuant to such election, and any deletions from or
modifications of or additions to the terms of this Indenture to provide for or to facilitate the
issuance of Securities denominated or payable, at the election of the Company or a Holder thereof
or otherwise, in a Foreign Currency;

     (15) whether the amount of payments of principal of, any premium or interest on or any
Additional Amounts with respect to such Securities may be determined with reference to an index,
formula, financial or economic measure or other method or methods (which index, formula, measure or
method or methods may be based, without limitation, on one or more Currencies, commodities, equity
indices or other indices), and, if so, the terms and conditions upon which and the manner in which
such amounts shall be determined and paid or be payable;

     (16) any deletions from, modifications of or additions to the Events of Default or covenants
of the Company with respect to any of such Securities, whether or not such Events of Default or
covenants are consistent with the Events of Default or covenants set forth herein;

     (17) whether either or both of Section 402(2) relating to defeasance or Section 402(3)
relating to covenant defeasance shall not be applicable to the Securities of such series, and any

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covenants relating to the Securities of such series which shall be subject to covenant defeasance,
and, if the Securities of such series are subject to repurchase or repayment at the option of the
Holders thereof, whether the Company’s obligation to repurchase or repay such Securities will be
subject to defeasance or covenant defeasance, and any deletions from, or modifications or additions
to, the provisions of Article Four in respect of the Securities of such series;

     (18) whether any of such Securities are to be issuable upon the exercise of warrants, and the
time, manner and place for such Securities to be authenticated and delivered;

     (19) if there is more than one Trustee or a Trustee other than The Bank of New York Mellon
Trust Company, N.A., the identity of the Trustee and, if not the Trustee, the identity of each
Security Registrar, Paying Agent or Authenticating Agent with respect to such Securities;

     (20) whether the Securities are senior or subordinated debt securities, and if subordinated
debt securities, the terms of such subordination;

     (21) whether the Securities of the series will be guaranteed by any Persons and, if so, the
identity of such Persons, the terms and conditions upon which such Securities shall be guaranteed
and, if applicable, the terms and conditions upon which such guarantees may be subordinated to
other indebtedness of the respective guarantors and may be released;

     (22) whether the Securities of the series will be secured by any collateral and, if so, the
terms and conditions upon which such Securities shall be secured and, if applicable, upon which
such liens may be subordinated to other liens securing other indebtedness of the Company or any
guarantor and may be released; and

     (23) any other terms of such Securities and any deletions from or modifications or additions
to this Indenture in respect of such Securities.

All Securities of any one series shall be substantially identical except as to denomination and
except as may otherwise be provided by the Company in or pursuant to the Board Resolution and set
forth in the Officer’s Certificate or in any indenture or indentures supplemental hereto pertaining
to such series of Securities. The terms of the Securities of any series may provide, without
limitation, that the Securities of such series shall be authenticated and delivered by the Trustee
on original issue from time to time in accordance with such procedures as are acceptable to the
Trustee (including authentication and delivery by the Trustee on original issue from time to time
upon telephonic or written order of persons designated in the Officer’s Certificate or supplemental
indenture (telephonic instructions to be promptly confirmed in writing by such person) and that
such persons are authorized to determine, consistent with such Officer’s Certificate or any
applicable supplemental indenture, such terms and conditions of the Securities of such series as
are specified in such Officer’s Certificate or supplemental indenture). All Securities of any one
series need not be issued at the same time and, unless otherwise so provided by the Company, a
series may be reopened for issuances of additional Securities of such series or to establish
additional terms of such series of Securities. If any of the terms of the Securities of any series
shall be established by action taken by or pursuant to a Board Resolution,
the Board Resolution shall be delivered to the Trustee at or prior to the delivery of the Officer’s
Certificate setting forth the terms of such series.

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Section 302 Currency; Denominations.

     Unless otherwise provided in or pursuant to this Indenture or any Security, the principal of,
any premium and interest on and any Additional Amounts with respect to, the Securities shall be
payable in Dollars. Unless otherwise provided in or pursuant to this Indenture, Registered
Securities denominated in Dollars shall be issuable in registered form without coupons in
denominations of $2,000 or any integral multiple of $1,000 in excess thereof. Securities not
denominated in Dollars shall be issuable in such denominations as are established with respect to
such Securities in or pursuant to this Indenture.

Section 303 Execution, Authentication, Delivery and Dating.

     Securities shall be executed on behalf of the Company by any Officer of the Company. The
signature of any such Officer on the Securities may be manual or facsimile.

     Securities bearing the manual or facsimile signatures of individuals who were at any time the
proper Officers of the Company shall bind the Company, notwithstanding that such individuals or any
of them have ceased to hold such offices prior to the authentication and delivery of such
Securities or did not hold such offices at the date of such Securities.

     At any time and from time to time after the execution and delivery of this Indenture, the
Company may deliver Securities, executed by the Company, to the Trustee for authentication and,
provided that the Board Resolution and Officer’s Certificate or supplemental indenture or
indentures with respect to such Securities referred to in Section 301 and a Company Order for the
authentication and delivery of such Securities have been delivered to the Trustee, the Trustee in
accordance with the Company Order and subject to the provisions hereof and of such Securities shall
authenticate and deliver such Securities. In authenticating such Securities, and accepting the
additional responsibilities under this Indenture in relation to such Securities, the Trustee shall
be provided with, and (subject to Sections 315(a) through 315(d) of the Trust Indenture Act) shall
be fully protected in relying upon an Opinion of Counsel and an Officer’s Certificate that contain
the statements required by Section 102 and shall also be entitled to receive an Opinion of Counsel
stating:

     (1) if the form or forms of such Securities have been established by or pursuant to a Board
Resolution as permitted by Section 201, that such form or forms have been established in conformity
with the provisions of this Indenture;

     (2) if the terms of such Securities have been, or in the case of Securities of a series that
are to be authenticated and delivered by the Trustee on original issue from time to time, will be,
established by or pursuant to a Board Resolution as permitted by Section 301, that such terms have
been, or in the case of Securities of a series that are to be authenticated and delivered by the
Trustee on original issue from time to time, will be, established in conformity with the provisions
of this Indenture, subject, in the case of Securities of a series that are to be authenticated and
delivered by the Trustee on original issue from time to time, to any conditions specified in
such Opinion of Counsel; and

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     (3) that such Securities, when authenticated and delivered by the Trustee and issued by the
Company in the manner and subject to any conditions specified in such Opinion of Counsel, will
constitute valid and legally binding obligations of the Company enforceable in accordance with
their terms, subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and
similar laws of general applicability relating to or affecting creditors’ rights and to general
equity principles.

If such forms or terms have been so established, the Trustee shall not be required to authenticate
such Securities if the issue of such Securities pursuant to this Indenture will affect the
Trustee’s own rights, duties or immunities under the Securities and this Indenture or otherwise in
a manner which is not reasonably acceptable to the Trustee.

     Notwithstanding the provisions of Section 301 and of the preceding paragraph, if all
Securities of a series are not to be originally issued at one time, it shall not be necessary to
deliver the Officer’s Certificate or Company Order otherwise required pursuant to such preceding
paragraph at or prior to the authentication of each Security of such series if such documents are
delivered at or prior to the authentication upon original issuance of the first Security of such
series to be issued. This paragraph shall not be applicable to Securities of a series that are
issued as part of a reopening pursuant to the last paragraph of Section 301.

     Each Registered Security shall be dated the date of its authentication.

     No Security shall be entitled to any benefit under this Indenture or be valid or obligatory
for any purpose, unless there appears on such Security a certificate of authentication
substantially in the form provided for in Section 202 or Section 612 executed by or on behalf of
the Trustee or by the Authenticating Agent by the manual signature of one of its authorized
signatories. Such certificate upon any Security shall be conclusive evidence, and the only
evidence, that such Security has been duly authenticated and delivered hereunder.

     Notwithstanding the foregoing, if any Security shall have been authenticated and delivered
hereunder but never issued and sold by the Company, and the Company shall deliver such Security to
the Trustee for cancellation as provided in Section 309, for all purposes of this Indenture such
Security shall be deemed never to have been authenticated and delivered hereunder and shall never
be entitled to the benefits of this Indenture.

Section 304 Temporary Securities.

     Pending the preparation of Definitive Securities, the Company may execute and deliver to the
Trustee and, upon Company Order, the Trustee shall authenticate and deliver, in the manner provided
in Section 303, temporary Securities in lieu thereof which are printed, lithographed, typewritten,
mimeographed or otherwise produced, in any authorized denomination, substantially of the tenor of
the Definitive Securities in lieu of which they are issued, in registered form and with such
appropriate insertions, omissions, substitutions and other variations as the Officers of the
Company executing such Securities may determine, as
conclusively evidenced by their execution of such Securities. Such temporary Securities may
be in the form of Global Securities.

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     Except in the case of temporary Global Securities, which shall be exchanged in accordance with
the provisions thereof, if temporary Securities are issued, the Company shall cause Definitive
Securities to be prepared without unreasonable delay. After the preparation of Definitive
Securities of the same series and containing terms and provisions that are identical to those of
any temporary Securities, such temporary Securities shall be exchangeable for such Definitive
Securities upon surrender of such temporary Securities at an Office or Agency for such Securities,
without charge to any Holder thereof. Upon surrender for cancellation of any one or more temporary
Securities, the Company shall execute and the Trustee shall authenticate and deliver in exchange
therefor a like principal amount of Definitive Securities of authorized denominations of the same
series and containing identical terms and provisions. Unless otherwise provided in or pursuant to
this Indenture with respect to a temporary Global Security, until so exchanged the temporary
Securities of any series shall in all respects be entitled to the same benefits under this
Indenture as Definitive Securities of such series.

Section 305 Registration, Transfer and Exchange.

     With respect to the Registered Securities of each series, if any, the Company shall cause to
be kept a register (each such register being herein sometimes referred to as the “Security
Register”) at an Office or Agency for such series in which, subject to such reasonable
regulations as it may prescribe, the Company shall provide for the registration of the Registered
Securities of such series and of transfers of the Registered Securities of such series.

     Such Office or Agency shall be the “Security Registrar” or “Registrar” for
that series of Securities. Unless otherwise specified in or pursuant to this Indenture or the
Securities, the Trustee shall be the initial Security Registrar for each series of Securities. The
Company shall have the right to remove and replace from time to time the Security Registrar for any
series of Securities; provided that no such removal or replacement shall be effective until a
successor Security Registrar with respect to such series of Securities shall have been appointed by
the Company and shall have accepted such appointment by the Company. In the event that the Trustee
shall not be or shall cease to be Security Registrar with respect to a series of Securities, it
shall have the right to examine the Security Register for such series at all reasonable times.
There shall be only one Security Register for each series of Securities.

     A Global Security may not be transferred as a whole except by the Depositary to a nominee of
the Depositary, by a nominee of the Depositary to the Depositary or to another nominee of the
Depositary, or by the Depositary or any such nominee to a successor Depositary or a nominee of such
successor Depositary. Notwithstanding the foregoing, except as may be provided pursuant to Section
301, any Global Security or any beneficial interest therein shall be exchangeable for Definitive
Securities only if (i) the Depositary is at any time unwilling, unable or ineligible to continue as
Depositary and a successor Depositary is not appointed by the Company within 90 days of the date
the Company is so informed in writing, (ii) the Depositary ceases to be a clearing agency
registered under the Exchange Act, (iii) the Company (subject to the Applicable Procedures)
executes and delivers to the Trustee a Company Order to the effect that such Global Security shall
be so exchangeable or (iv) an Event of Default has occurred and
is continuing with respect to such Securities. If the holder of a Global Security or the
beneficial owners of interests in a Global Security are entitled to exchange such interests for
Definitive Securities as the result of an event specified in clause (i), (ii), (iii) or (iv) of the
preceding

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sentence, the Company shall promptly make available to the Trustee Definitive Securities
in such form and denominations as are required by or pursuant to this Indenture, and of the same
series, containing identical terms and in aggregate principal amount equal to the principal amount
of such Global Security, executed by the Company. Such Global Security shall be surrendered from
time to time by the U.S. Depositary or such other Depositary as shall be specified in the Company
Order with respect thereto, and in accordance with instructions given to the Trustee and the U.S.
Depositary or such other Depositary, as the case may be (which instructions shall be in writing but
need not be contained in or accompanied by an Officer’s Certificate or be accompanied by an Opinion
of Counsel), as shall be specified in the Company Order with respect thereto to the Trustee, as the
Company’s agent for such purpose, to be exchanged, in whole or in part, for Definitive Securities
as described above without charge. The Trustee shall authenticate and make available for delivery,
in exchange for each portion of such surrendered Global Security, a like aggregate principal amount
of Definitive Securities of the same series of authorized denominations and of like tenor as the
portion of such Global Security to be exchanged; provided, however, that no such exchanges may
occur during a period beginning at the opening of business 15 days before any selection of
Securities of the same series to be redeemed and ending on the relevant Redemption Date. Promptly
following any such exchange in part, such Global Security shall be returned by the Trustee to such
Depositary or the U.S. Depositary, as the case may be, or such other Depositary or U.S. Depositary
referred to above in accordance with the instructions of the Company referred to above. If a
Registered portion of a Global Security is exchanged for Definitive Registered Securities after the
close of business at the Office or Agency for such Security where such exchange occurs on or after
(i) any Regular Record Date for such Security and before the opening of business at such Office or
Agency on the next Interest Payment Date, or (ii) any Special Record Date for such Security and
before the opening of business at such Office or Agency on the related proposed date for payment of
interest or Defaulted Interest, as the case may be, interest shall not be payable on such Interest
Payment Date or proposed date for payment, as the case may be, in respect of such Definitive
Registered Security, but shall be payable on such Interest Payment Date or proposed date for
payment, as the case may be, only to the Person to whom interest in respect of such portion of such
Global Security shall be payable in accordance with the provisions of this Indenture.

     The transfer and exchange of beneficial interests in the Global Securities shall be effected
through the Depositary, in accordance with the provisions of this Indenture and the Applicable
Procedures. Transfers and exchanges of beneficial interests in the Global Securities also shall
require compliance with either subparagraph (1) or (2) below, as applicable, as well as one or more
of the other following paragraphs, as applicable:

     (1) Beneficial interests in any Global Security may be transferred to Persons who take
delivery thereof in the form of a beneficial interest in the same Global Security. No written
orders or instructions shall be required to be delivered to the Registrar to effect the transfers
described in this subparagraph (1).

     (2) In connection with the transfer or exchange of beneficial interests in any Global Security
to Persons who take delivery thereof in the form of a beneficial interest in a different
Global Security, the transferor of such beneficial interest must deliver to the Registrar (i)
an order from a Participant or an Indirect Participant given to the Depositary in accordance with
the Applicable Procedures directing the Depositary to credit or cause to be credited a beneficial

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interest in another Global Security in an amount equal to the beneficial interest to be transferred
or exchanged and (ii) instructions given in accordance with the Applicable Procedures containing
information regarding the Participant account to be credited with such increase. Upon satisfaction
of all of the requirements for transfer or exchange of beneficial interests in Global Securities
contained in this Indenture and such Securities or otherwise applicable under the Securities Act,
the Trustee shall adjust the principal amount of the relevant Global Security(s) pursuant to this
paragraph.

     If any Holder of a beneficial interest in a Global Security proposes to exchange such
beneficial interest for a Definitive Security or to transfer such beneficial interest to a Person
who takes delivery thereof in the form of a Definitive Security in the event of the occurrence of
any of the conditions set forth in the third paragraph of this Section 305, then, upon delivery to
the Registrar of (i) an order from a Participant or an Indirect Participant given to the Depositary
in accordance with the Applicable Procedures directing the Depositary to cause to be issued a
Definitive Security in an amount equal to the beneficial interest to be transferred or exchanged
and (ii) instructions given by the Depositary to the Registrar containing information regarding the
Person in whose name such Definitive Security shall be registered to effect the transfer or
exchange referred to in clause (i), the Trustee shall cause the aggregate principal amount of the
applicable Global Security to be reduced accordingly as described below, and the Company shall
execute and, upon receipt of a Company Order pursuant to Section 303, the Trustee shall
authenticate and deliver to the Person designated in the instructions a Definitive Security in the
appropriate principal amount. Any Definitive Security issued in exchange for a beneficial interest
pursuant to this paragraph shall be registered in such name or names and in such authorized
denomination or denominations as the Holder of such beneficial interest shall instruct the
Registrar through instructions from the Depositary and the Participant or Indirect Participant.
The Trustee shall deliver such Definitive Securities to the Persons in whose names such Securities
are so registered.

     A Holder of a Definitive Security may exchange such Security for a beneficial interest in a
Global Security or transfer such Definitive Securities to a Person who takes delivery thereof in
the form of a beneficial interest in a Global Security at any time. Upon receipt of a request for
such an exchange or transfer, the Trustee shall cancel the applicable Definitive Security and
increase or cause to be increased the aggregate principal amount of the applicable Global Security.

     At the option of the Holder, Definitive Securities of any series may be exchanged for other
Definitive Securities of the same series, of any authorized denominations and of like tenor and
aggregate principal amount, upon surrender of the Definitive Securities to be exchanged at an
Office or Agency. Whenever any Definitive Securities are so surrendered for exchange, the Company
shall execute, and the Trustee shall authenticate and deliver, the Definitive Securities which the
Holder making the exchange is entitled to receive.

     Upon request by a Holder of Definitive Securities and such Holder’s compliance with the
provisions of this paragraph, the Registrar shall register the transfer or exchange of Definitive
Securities. Prior to such registration of transfer or exchange, the requesting Holder shall
present or surrender to the Registrar the Definitive Securities duly endorsed or accompanied by a
written instruction of transfer in form satisfactory to the Registrar duly executed by such Holder
or by its

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attorney, duly authorized in writing. A Holder of Definitive Securities may transfer
such Securities to a Person who takes delivery thereof in the form of a Definitive Security. Upon
receipt of a request to register such a transfer, the Registrar shall register the Definitive
Securities pursuant to the instructions from the Holder thereof.

     At such time as all beneficial interests in a particular Global Security have been exchanged
for Definitive Securities or a particular Global Security has been redeemed, repurchased or
cancelled in whole and not in part, each such Global Security shall be returned to or retained and
cancelled by the Trustee in accordance with Section 309. At any time prior to such cancellation,
if any beneficial interest in a Global Security is exchanged for or transferred to a Person who
will take delivery thereof in the form of a beneficial interest in another Global Security or for
Definitive Securities, the principal amount of Securities represented by such Global Security shall
be reduced accordingly and an endorsement shall be made on such Global Security by the Trustee or
by the Depositary at the direction of the Trustee to reflect such reduction; and if the beneficial
interest is being exchanged for or transferred to a Person who will take delivery thereof in the
form of a beneficial interest in another Global Security, the principal amount of Securities
represented by such other Global Security shall be increased accordingly and an endorsement shall
be made on such Global Security by the Trustee or by the Depositary at the direction of the Trustee
to reflect such increase.

     All Securities issued upon any registration of transfer or exchange of Securities shall be the
valid and legally binding obligations of the Company evidencing the same debt and entitling the
Holders thereof to the same benefits under this Indenture as the Securities surrendered upon such
registration of transfer or exchange.

     Every Registered Security presented or surrendered for registration of transfer or for
exchange or redemption shall (if so required by the Company or the Security Registrar for such
Security) be duly endorsed, signature guaranteed, or be accompanied by a written instrument of
transfer in form satisfactory to the Company and the Security Registrar for such Security duly
executed by the Holder thereof, signature guaranteed, or his attorney duly authorized in writing.

     No service charge shall be made for any registration of transfer or exchange, or redemption of
Securities, but the Company may require payment of a sum sufficient to cover any tax or other
governmental charge and any other expenses (including fees and expenses of the Trustee) that may be
imposed in connection with any registration of transfer or exchange of Securities, other than
exchanges pursuant to Sections 304, 306, 906 and 1107 not involving any transfer.

     Except as otherwise provided in or pursuant to this Indenture, the Company shall not be
required (i) to issue, register the transfer of or exchange any Securities during a period
beginning at the opening of business 15 days before the day of selection of Securities of like
tenor and the same series under Section 1103 for redemption and ending at the close of business on
the day of
such selection, (ii) to register the transfer of or exchange any Registered Security so
selected for redemption in whole or in part, except in the case of any Security to be redeemed in
part, the portion thereof not to be redeemed, or (iii) to issue, register the transfer of or
exchange any

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Security which, in accordance with its terms, has been surrendered for repayment or
purchase at the option of the Holder, except the portion, if any, of such Security not to be so
repaid.

     The Registrar shall retain copies of all certificates, notices and other written
communications received pursuant to this Section 305. The Company shall have the right to inspect
and make copies of all such certificates, notices or other written communications at any reasonable
time upon the giving of reasonable written notice to the Registrar.

     All certifications and certificates required to be submitted to the Registrar pursuant to this
Section 305 to effect a registration of transfer or exchange may be submitted by facsimile, with an
original of such document to be sent promptly thereafter.

Section 306 Mutilated, Destroyed, Lost and Stolen Securities.

     If any mutilated Security is surrendered to the Trustee, subject to the provisions of this
Section 306, the Company shall execute and the Trustee shall authenticate and deliver in exchange
therefor a new Security of the same series containing identical terms and of like principal amount
and bearing a number not contemporaneously outstanding.

     If there be delivered to the Company and to the Trustee (i) evidence to their satisfaction of
the destruction, loss or theft of any Security and (ii) such security or indemnity as may be
required by them to save each of them and any agent of either of them harmless, then, in the
absence of notice to the Company or to a Responsible Officer that such Security has been acquired
by a “protected purchaser” (as such term is defined in the New York Uniform Commercial Code), the
Company shall execute and, upon the Company’s request the Trustee shall authenticate and deliver,
in exchange for or in lieu of any such destroyed, lost or stolen Security, a new Security of the
same series containing identical terms and of like principal amount and bearing a number not
contemporaneously outstanding.

     Notwithstanding the foregoing provisions of this Section 306, in case any mutilated,
destroyed, lost or stolen Security has become or is about to become due and payable, the Company in
its discretion may, instead of issuing a new Security, pay such Security.

     Upon the issuance of any new Security under this Section 306, the Company may require the
payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in
relation thereto and any other expenses (including the fees and expenses of the Trustee) connected
therewith.

     Every new Security issued pursuant to this Section 306 in lieu of any destroyed, lost or
stolen Security shall constitute a separate obligation of the Company, whether or not the
destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be
entitled to all the benefits of this Indenture equally and proportionately with any and all other
Securities of such series duly issued hereunder.

     The provisions of this Section 306, as amended or supplemented pursuant to this Indenture with
respect to particular Securities or generally, shall be exclusive and shall preclude (to the extent
lawful) all other rights and remedies with respect to the replacement or payment of mutilated,
destroyed, lost or stolen Securities.

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Section 307 Payment of Interest and Certain Additional Amounts; Rights to Interest and Certain
Additional Amounts Preserved.

     Unless otherwise provided in or pursuant to this Indenture, any interest on and any Additional
Amounts with respect to, any Registered Security which shall be payable, and are punctually paid or
duly provided for, on any Interest Payment Date shall be paid to the Person in whose name such
Security (or one or more Predecessor Securities) is registered as of the close of business on the
Regular Record Date for such interest.

     Unless otherwise provided in or pursuant to this Indenture, any interest on and any Additional
Amounts with respect to, any Registered Security which shall be payable, but shall not be
punctually paid or duly provided for, on any Interest Payment Date for such Registered Security
(herein called “Defaulted Interest”) shall forthwith cease to be payable to the Holder
thereof on the relevant Regular Record Date by virtue of having been such Holder; and such
Defaulted Interest may be paid by the Company, at its election in each case, as provided in clause
(1) or (2) below:

     (1) The Company may elect to make payment of any Defaulted Interest to the Person in whose
name such Registered Security (or a Predecessor Security thereof) shall be registered at the close
of business on a Special Record Date for the payment of such Defaulted Interest, which shall be
fixed in the following manner. The Company shall notify the Trustee in writing of the amount of
Defaulted Interest proposed to be paid on such Registered Security and the date of the proposed
payment, and at the same time the Company shall deposit with the Trustee an amount of money equal
to the aggregate amount proposed to be paid in respect of such Defaulted Interest or shall make
arrangements satisfactory to the Trustee for such deposit on or prior to the date of the proposed
payment, such money when so deposited to be held in trust for the benefit of the Person entitled to
such Defaulted Interest as in this clause provided. Thereupon, the Trustee shall fix a Special
Record Date for the payment of such Defaulted Interest which shall be not more than 15 days and not
less than 10 days prior to the date of the proposed payment and not less than 10 days after the
receipt by the Trustee of the notice of the proposed payment. The Trustee shall promptly notify
the Company of such Special Record Date and, in the name and at the expense of the Company, shall
cause notice of the proposed payment of such Defaulted Interest and the Special Record Date
therefor to be mailed, first-class postage prepaid, to the Holder of such Registered Security (or a
Predecessor Security thereof) at his address as it appears in the Security Register not less than
10 days prior to such Special Record Date. The Trustee may, in its discretion, in the name and at
the expense of the Company, cause a similar notice to be published at least once in an Authorized
Newspaper of general circulation in the Borough of Manhattan, The City of New York, but such
publication shall not be a condition precedent to the establishment of such Special Record Date.
Notice of the proposed payment of such Defaulted Interest and the Special Record Date therefor
having been mailed as aforesaid, such Defaulted Interest shall be paid to the Person in whose name
such Registered Security (or a
Predecessor Security thereof) shall be registered at the close of business on such Special
Record Date and shall no longer be payable pursuant to the following clause (2).

     (2) The Company may make payment of any Defaulted Interest in any other lawful manner not
inconsistent with the requirements of any securities exchange on which such Security may be listed,
and upon such notice as may be required by such exchange, if, after notice given

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by the Company to
the Trustee of the proposed payment pursuant to this clause, such payment shall be deemed
practicable by the Trustee.

     Unless otherwise provided in or pursuant to this Indenture or the Securities of any particular
series pursuant to the provisions of this Indenture, at the option of the Company, interest on
Registered Securities that bear interest may be paid by wire transfer in immediately available
funds if the Holder of the Registered Security has provided to the Company and the Trustee wire
instructions at least five Business Days prior to the applicable payment date or by check mailed to
the address of that Holder as it appears on the books of the Securities Registrar if that Holder
has not provided wire instructions; provided that any payment of principal (or premium, if any) in
respect of any Security will be made only upon presentation and surrender of such Security at the
applicable Office or Agency.

     Subject to the foregoing provisions of this Section 307 and Section 305, each Security
delivered under this Indenture upon registration of transfer of or in exchange for or in lieu of
any other Security shall carry the rights to interest accrued and unpaid, and to accrue, which were
carried by such other Security.

     In the case of any Registered Security of any series that is convertible, which Registered
Security is converted after any Regular Record Date and on or prior to the immediately succeeding
Interest Payment Date (other than any Registered Security with respect to which the Maturity is
prior to such Interest Payment Date), interest on such Interest Payment Date shall be payable on
such Interest Payment Date notwithstanding such conversion, and such interest (whether or not
punctually paid or duly provided for) shall be paid to the Person in whose name that Registered
Security (or one or more predecessor Registered Securities) is registered at the close of business
on such Regular Record Date. Except as otherwise expressly provided in the immediately preceding
sentence, in the case of any Registered Security which is converted, interest with respect to which
the Stated Maturity is after the date of conversion of such Registered Security shall not be
payable.

Section 308 Persons Deemed Owners.

     Prior to due presentment of a Registered Security for registration of transfer, the Company,
the Trustee and any agent of the Company or the Trustee may treat the Person in whose name such
Registered Security is registered in the Security Register as the owner of such Registered Security
for the purpose of receiving payment of principal of, any premium and (subject to Section 305 and
Section 307) interest on and any Additional Amounts with respect to, such Registered Security and
for all other purposes whatsoever, whether or not any payment with respect to such Registered
Security shall be overdue, and none of the Company, the Trustee or any agent of the Company or the
Trustee shall be affected by notice to the contrary.

     No holder of any beneficial interest in any Global Security held on its behalf by a Depositary
shall have any rights under this Indenture with respect to such Global Security, and such
Depositary may be treated by the Company, the Trustee and any agent of the Company or the Trustee
as the owner of such Global Security for all purposes whatsoever. None of the Company, the
Trustee, any Paying Agent or the Security Registrar will have any responsibility or liability for
any aspect of the records relating to or payments made on account of beneficial

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ownership interests
of a Global Security or for maintaining, supervising or reviewing any records relating to such
beneficial ownership interests.

Section 309 Cancellation.

     All Securities surrendered for payment, redemption, registration of transfer, exchange or
conversion or for credit against any sinking fund payment shall, if surrendered to any Person other
than the Trustee, be delivered to the Trustee, and any such Securities, as well as Securities
surrendered directly to the Trustee for any such purpose, shall be cancelled promptly by the
Trustee. The Company may at any time deliver to the Trustee for cancellation any Securities
previously authenticated and delivered hereunder which the Company may have acquired in any manner
whatsoever, and all Securities so delivered shall be cancelled promptly by the Trustee. No
Securities shall be authenticated in lieu of or in exchange for any Securities cancelled as
provided in this Section 309, except as expressly permitted by or pursuant to this Indenture. All
cancelled Securities held by the Trustee shall be disposed of by the Trustee in accordance with its
customary procedures.

Section 310 Computation of Interest.

     Except as otherwise provided in or pursuant to this Indenture, or in any Security, interest on
the Securities shall be computed on the basis of a 360-day year of twelve 30-day months.

Section 311 CUSIP and ISIN Numbers.

     The Company in issuing the Securities may use “CUSIP” and “ISIN” numbers (if then generally in
use), and, if so, the Trustee shall use CUSIP and ISIN numbers in notices of redemption as a
convenience to Holders; provided that any such notice may state that no representation is made as
to the correctness of such numbers either as printed on the Securities or as contained in any
notice of a redemption and that reliance may be placed only on the other identification numbers
printed on the Securities, and any such redemption shall not be affected by any defect in or
omission of such numbers. The Company will promptly notify the Trustee of any change in the CUSIP
and ISIN numbers.

ARTICLE FOUR

SATISFACTION AND DISCHARGE OF INDENTURE

Section 401 Satisfaction and Discharge.

     Upon the direction of the Company by a Company Order, this Indenture shall cease to be of
further effect with respect to any series of Securities specified in such Company Order and the
Trustee, on receipt of a Company Order, at the expense of the Company, shall execute proper
instruments acknowledging satisfaction and discharge of this Indenture as to such series, when

     (1) either

     (a) all Securities of such series theretofore authenticated and delivered have been
delivered to the Trustee for cancellation (other than (i) Securities of such series which

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have been destroyed, lost or stolen and which have been replaced or paid as provided in
Section 306 and (ii) Securities of such series the payment of money for which has
theretofore been deposited in trust or segregated and held in trust by the Company and
thereafter repaid to the Company or discharged from such trust, as provided in Section
1003); or

     (b) all Securities of such series not theretofore delivered to the Trustee for
cancellation:

	 	(ii)	 	have become due and payable, or
	 
	 	(iii)	 	will become due and payable at their Stated Maturity within
one year, or
	 
	 	(iv)	 	if redeemable at the option of the Company, are to be called
for redemption within one year under arrangements satisfactory to the Trustee
for the giving of notice of redemption by the Trustee in the name, and at the
expense, of the Company,

and the Company, in the case of (i), (ii) or (iii) above, has deposited or caused to be
deposited with the Trustee as trust funds in trust for such purpose, (x) money in an amount
or (y) Government Obligations that through the payment of interest and principal in respect
thereof in accordance with their terms will provide, not later than one day before the due
date of any payment, in the opinion of a nationally recognized Independent Registered Public
Accounting Firm expressed in a written certification thereof delivered to the Trustee, money
in the amount, or (z) a combination of (x) and (y) in an amount in the Currency in which
such series of Securities are payable sufficient to pay and discharge the entire
indebtedness on such Securities not theretofore delivered to the Trustee for cancellation,
including the principal of, any premium and interest on, and any Additional Amounts with
respect to such Securities then determinable, to the date of such deposit (in the case of
Securities which have become due and payable) or to the Maturity thereof, as the case may
be;

     (2) the Company has paid or caused to be paid all other sums payable hereunder by the Company
with respect to the Outstanding Securities of such series; and

     (3) the Company has delivered to the Trustee an Officer’s Certificate and an Opinion of
Counsel, each stating that all conditions precedent herein provided for relating to the
satisfaction and discharge of this Indenture as to such series have been complied with.

     In the event there are Securities of two or more series hereunder, the Trustee shall be
required to execute an instrument acknowledging satisfaction and discharge of this Indenture
only if requested to do so with respect to Securities of such series as to which it is Trustee
and if the other conditions thereto are met.

     Notwithstanding the satisfaction and discharge of this Indenture with respect to any series of
Securities, the obligations of the Company to the Trustee under Section 607, the obligations of the
Trustee under Section 403, if money, Government Obligations or a combination thereof shall have
been deposited with the Trustee pursuant to subclause (b) of clause (1) of this Section 401,

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the
obligations of the Company and the Trustee with respect to the Securities of such series under
Section 304, Section 305, Section 306, Section 1002 and Section 1003, and the obligations of the
Company with respect to the payment of Additional Amounts, if any, with respect to such Securities
as contemplated by Section 1004 (but only to the extent that the Additional Amounts payable with
respect to such Securities exceed the amount deposited in respect of such Additional Amounts
pursuant to Section 401(1)(b)), and with respect to any rights to convert or exchange such
Securities into Common Stock or other securities, cash or other property shall survive such
satisfaction and discharge.

Section 402 Defeasance and Covenant Defeasance.

     (1) Unless pursuant to Section 301, either or both of (i) defeasance of the Securities of a
series under clause (2) of this Section 402 shall not be applicable with respect to the Securities
of such series or (ii) covenant defeasance of the Securities of a series under clause (3) of this
Section 402 shall not be applicable with respect to the Securities of such series, then such
provisions, together with the other provisions of this Section 402 (with such modifications thereto
as may be specified pursuant to Section 301 with respect to any Securities), shall be applicable to
such Securities, and the Company may at its option by Board Resolution, at any time, with respect
to such Securities, elect to have Section 402(2) or Section 402(3) be applied to such Outstanding
Securities upon compliance with the conditions set forth below in this Section 402.

     (2) Upon the Company’s exercise of the above option applicable to this Section 402(2) with
respect to any Securities of or within a series, the Company shall be deemed to have been
discharged from its obligations with respect to such Outstanding Securities on the date the
conditions set forth in clause (4) of this Section 402 are satisfied (hereinafter,
“defeasance”). For this purpose, such defeasance means that the Company shall be deemed to
have paid and discharged the entire indebtedness represented by such Outstanding Securities, which
shall thereafter be deemed to be “Outstanding” only for the purposes of the Sections of this
Indenture referred to in clauses (i) and (ii) below, and to have satisfied all of its other
obligations under such Securities and this Indenture insofar as such Securities are concerned (and
the Trustee, at the expense of the Company, shall execute proper instruments acknowledging the
same), except for the following which shall survive until otherwise terminated or discharged
hereunder: (i) the rights of Holders of such Outstanding Securities to receive, solely from the
trust fund described in clause (4) of this Section 402 and as more fully set forth in such Section,
payments in respect of the principal of (and premium, if any) and interest, if any, on, and
Additional Amounts, if any, with respect to, such Securities when such payments are due, and any
rights of such Holder to convert or exchange such Securities into Common Stock or other securities,
cash or other property, (ii) the obligations of the Company and the Trustee with respect to such
Securities under Section 304, Section 305, Section 306, Section 1002 and Section 1003 and the
obligations
of the Company with respect to the payment of Additional Amounts, if any, on such Securities
as contemplated by Section 1004 (but only to the extent that the Additional Amounts payable with
respect to such Securities exceed the amount deposited in respect of such Additional Amounts
pursuant to Section 402(4)(a) below), and with respect to any rights to convert or exchange such
Securities into Common Stock or other securities, cash or other property, (iii) the rights, powers,
trusts, duties and immunities of the Trustee hereunder and (iv) this Section 402. The Company

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may
exercise its option under this Section 402(2) notwithstanding the prior exercise of its option
under clause (3) of this Section 402 with respect to such Securities.

     (3) Upon the Company’s exercise of the above option applicable to this Section 402(3) with
respect to any Securities of or within a series, (i) the Company shall be released from its
obligations to comply with any term, provision or condition under Section 801 with respect to such
Securities (and, to the extent specified pursuant to Section 301, any other restrictive covenant
added for the benefit of such Securities) and (ii) unless otherwise specified pursuant to Section
301, the occurrence of any event specified in Section 501(7) shall not be deemed to be an Event of
Default, in each case on and after the date the conditions set forth in clause (4) of this Section
402 are satisfied (hereinafter, “covenant defeasance”), and such Securities shall
thereafter be deemed to be not “Outstanding” for the purposes of any direction, waiver, consent or
declaration or Act of Holders (and the consequences of any thereof) in connection with any such
covenant, but shall continue to be deemed “Outstanding” for all other purposes hereunder. For this
purpose, such covenant defeasance means that, with respect to such Outstanding Securities, the
Company may omit to comply with, and shall have no liability in respect of, any term, condition or
limitation set forth in any such covenant, whether directly or indirectly, by reason of any
reference elsewhere herein to any covenant or by reason of reference in any such covenant to any
other provision herein or in any other document and such omission to comply shall not constitute a
default or an Event of Default under Section 501(4), Section 501(7) or otherwise, as the case may
be, insofar as it relates to Section 801 and, to the extent specified pursuant to Section 301, any
other restrictive covenant added for the benefit of such Security, but, except as specified above,
the remainder of this Indenture and such Securities shall be unaffected thereby; provided that the
obligations of the Company with respect to the payment of Additional Amounts, if any, on such
Securities as contemplated by Section 1004 shall remain unsatisfied only to the extent that the
Additional Amounts payable with respect to such Securities exceed the amount deposited in respect
of such Additional Amounts pursuant to Section 402(4)(a) below; provided, further, that
notwithstanding a covenant defeasance with respect to Section 801, any Person to whom a sale,
assignment, transfer, lease, conveyance or other disposition is made pursuant to Section 801, shall
as a condition to such sale, assignment, transfer, lease, conveyance or other disposition, assume
by an indenture supplemental hereto in form satisfactory to the Trustee, executed by such successor
Person and delivered to the Trustee, the obligations of the Company to the Trustee under Section
607 and the second to the last paragraph of Section 402.

     (4) The following shall be the conditions to the application of clause (2) or (3) of this
Section 402 to any Outstanding Securities of a series:

     (a) The Company shall irrevocably have deposited or caused to be deposited with the
Trustee (or another trustee satisfying the requirements of Section 608 who shall agree to
comply with the provisions of this Section 402 applicable to it) as trust funds in trust
for the purpose of making the following payments, specifically pledged as security for,
and dedicated solely to, the benefit of the Holders of such Securities, (1) an amount in
Dollars or in such Foreign Currency in which such Securities are then specified as payable
at Stated Maturity, or (2) Government Obligations applicable to such Securities (determined
on the basis of the Currency in which such Securities are then specified as payable at
Stated Maturity) which through the scheduled payment of principal and

35

 

interest in respect
thereof in accordance with their terms will provide, not later than one day before the due
date of any payment of principal of (and premium, if any) and interest, if any, on such
Securities, money in an amount, or (3) a combination thereof, in any case, in an amount,
sufficient, without consideration of any reinvestment of such principal and interest, in the
opinion of a nationally recognized Independent Registered Public Accounting Firm expressed
in a written certification thereof delivered to the Trustee, to pay and discharge, and which
shall be applied by the Trustee (or other qualifying trustee) to pay and discharge, (y) the
principal of (and premium, if any) and interest or Additional Amounts then determinable, if
any, on such Outstanding Securities at the Maturity of such principal or installment of
principal or interest, provided that the Company shall specify whether such Outstanding
Securities are being defeased to Stated Maturity or to the Redemption Date and (z) any
mandatory sinking fund payments or analogous payments applicable to such Outstanding
Securities on the day on which such payments are due and payable in accordance with the
terms of this Indenture and of such Securities.

     (b) Such defeasance or covenant defeasance shall not result in a breach or violation
of, or constitute a default under, this Indenture or any other material agreement or
instrument to which the Company is a party or by which it is bound.

     (c) No Event of Default or event which with notice or lapse of time or both would
become an Event of Default with respect to such Securities shall have occurred and be
continuing on the date of such deposit (other than an Event of Default resulting from
non-compliance with any covenant from which the Company is released upon effectiveness of
such defeasance or covenant defeasance, as applicable).

     (d) In the case of an election under clause (2) of this Section 402, the Company shall
have delivered to the Trustee an Opinion of Counsel stating that

	 	(ii)	 	the Company has received from the Internal Revenue Service a
letter ruling, or there has been published by the Internal Revenue Service a
Revenue Ruling, or
	 
	 	(iii)	 	since the date of execution of this Indenture, there has been
a change in the applicable federal income tax law,

in either case to the effect that, and based thereon such opinion shall confirm that,
subject to customary assumptions and exclusions, the Holders of such Outstanding Securities
will not recognize income, gain or loss for federal income tax purposes as a result of such
defeasance and will be subject to federal income tax on the same amounts, in the same manner
and at the same times as would have been the case if such defeasance had not occurred.

     (e) In the case of an election under clause (3) of this Section 402, the Company shall
have delivered to the Trustee an Opinion of Counsel to the effect that, subject to customary
assumptions and exclusions, the Holders of such Outstanding Securities will not recognize
income, gain or loss for federal income tax purposes as a result of such covenant defeasance
and will be subject to federal income tax on the same amounts, in

36

 

the same manner and at the
same times as would have been the case if such covenant defeasance had not occurred.

     (f) The Company shall have delivered to the Trustee an Officer’s Certificate and an
Opinion of Counsel, each stating that all conditions precedent to the defeasance or covenant
defeasance under clause (2) or (3) of this Section 402 (as the case may be) have been
complied with.

     (g) If the Securities are to be redeemed prior to their Stated Maturity (other than
from mandatory sinking fund payments or analogous payments), notice of such redemption shall
have been duly given pursuant to this Indenture or provision therefor satisfactory to the
Trustee shall have been made.

     (h) Notwithstanding any other provisions of this Section 402(4), such defeasance or
covenant defeasance shall be effected in compliance with any additional or substitute terms,
conditions or limitations which may be imposed on the Company in connection therewith
pursuant to Section 301.

     The Company shall pay and indemnify the Trustee against any tax, fee or other charge, imposed
on or assessed against the Government Obligations deposited pursuant to this Section 402 or the
principal or interest received in respect thereof other than any such tax, fee or other charge
which by law is for the account of the Holders of such Outstanding Securities.

     Anything in this Section 402 to the contrary notwithstanding, the Trustee shall deliver or pay
to the Company from time to time upon Company Request any money or Government Obligations (or other
property and any proceeds therefrom) held by it as provided in clause (4) of this Section 402
which, in the opinion of a nationally recognized Independent Registered Public Accounting Firm
expressed in a written certification thereof delivered to the Trustee, are in excess of the amount
thereof which would then be required to be deposited to effect a defeasance or covenant defeasance,
as applicable, in accordance with this Section 402.

Section 403 Application of Trust Money.

     Subject to the provisions of the last paragraph of Section 1003, all money and Government
Obligations (including the proceeds thereof) deposited with the Trustee or other qualifying trustee
(solely for purposes of this Section 403, the Trustee and any such other trustee are referred to
collectively as the “Trustee”) pursuant to Section 401 or Section 402 in respect of any Outstanding
Securities of any series shall be held in trust and applied by the Trustee, in accordance with the
provisions of the Securities and this Indenture, to the payment, either directly or through any
Paying Agent (including the Company acting as its own Paying Agent) as the Trustee may determine,
to the Persons entitled thereto, of the principal, premium, if any, interest and Additional
Amounts, if any, for whose payment such money has or Government
Obligations have been deposited with or received by the Trustee; but such money and Government
Obligations need not be segregated from other funds except to the extent required by law.

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Section 404 Qualifying Trustee.

     Any trustee appointed pursuant to Section 402 for the purpose of holding trust funds deposited
pursuant to that Section shall be appointed under an agreement in form acceptable to the Trustee
and shall provide to the Trustee a certificate of such trustee, upon which certificate the Trustee
shall be entitled to conclusively rely, that all conditions precedent provided for herein to the
related defeasance or covenant defeasance have been complied with. In no event shall the Trustee
be liable for any acts or omissions of said trustee.

ARTICLE FIVE

REMEDIES

Section 501 Events of Default.

     “Event of Default,” wherever used herein with respect to Securities of any series,
means any one of the following events (whatever the reason for such Event of Default and whether it
shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment,
decree or order of any court or any order, rule or regulation of any administrative or governmental
body), unless such event is specifically deleted or modified in or pursuant to the supplemental
indenture, Board Resolution or Officer’s Certificate establishing the terms of such series pursuant
to this Indenture:

     (1) default for 30 days in the payment when due of any interest on or any Additional Amount in
respect of any Security of such series;

     (2) default in the payment of the principal of or any premium on any Security of such series
when the principal or premium becomes due and payable at Maturity;

     (3) default in the deposit of any sinking fund payment when and as due by the terms of any
Security of such series, subject to any cure period specified in any Security of such series;

     (4) failure on the part of the Company duly to observe or perform any other of the covenants
or agreements (other than those described in clause (1), (2) or (3) above) on the part of the
Company with respect to that series contained in such Securities or otherwise established with
respect to that series of Securities pursuant to Section 301 hereof or contained in this Indenture
(other than a covenant or agreement which has been expressly included in this Indenture solely for
the benefit of one or more series of Securities other than such series) and such failure shall
continue for a period of 60 days after the date on which written notice of such failure, requiring
the same to be remedied and stating that such notice is a “Notice of Default” shall have been given
to the Company by the Trustee, upon direction of Holders of at least 25% in principal amount of the
Outstanding Securities of that series; provided, however, that if such failure is not capable of
cure within such 60-day period, such 60-day period shall be automatically extended by an additional
60 days so long as (i) such failure is subject to cure, and
(ii) the Company is using commercially reasonable efforts to cure such failure; and provided,
further, that a failure to comply with any such other agreement in the indenture that results from
a change in GAAP shall not be deemed to be an Event of Default;

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     (5) a decree or order by a court having jurisdiction in the premises shall have been entered
adjudging the Company bankrupt or insolvent, or approving as properly filed a petition seeking
liquidation or reorganization of the Company under any applicable bankruptcy, insolvency,
reorganization or other similar law, and such decree or order shall have continued unvacated and
unstayed for a period of 90 days; an involuntary case shall be commenced under any applicable
bankruptcy, insolvency, reorganization or other similar law in respect of the Company and shall
continue undismissed for a period of 90 days or an order for relief in such case shall have been
entered and such order shall have remained in force unvacated and unstayed for a period of 90 days;
or a decree or order of a court having jurisdiction in the premises shall have been entered for the
appointment on the ground of insolvency or bankruptcy of a receiver, custodian, liquidator, trustee
or assignee in bankruptcy or insolvency of the Company or of its property, or for the winding up or
liquidation of its affairs, and such decree or order shall have remained in force unvacated and
unstayed for a period of 90 days;

     (6) the Company shall institute proceedings to be adjudicated a voluntary bankrupt, shall
consent to the filing of a bankruptcy proceeding against it, shall file a petition or answer or
consent seeking liquidation or reorganization under any applicable bankruptcy, insolvency,
reorganization or other similar law, shall consent to the filing of any such petition or shall
consent to the appointment on the ground of insolvency or bankruptcy of a receiver or custodian or
liquidator or trustee or assignee in bankruptcy or insolvency of it or of its property, or shall
make a general assignment for the benefit of creditors; or

     (7) any other Event of Default provided in or pursuant to the Indenture with respect to
Securities of the series, provided that any such Event of Default that results from a change in
GAAP shall not be deemed to be an Event of Default.

Section 502 Acceleration of Maturity; Rescission and Annulment.

     If an Event of Default specified in clause (5) or (6) of the definition thereof above occurs,
the principal of all Securities shall automatically become due and payable without further action
or notice, anything contained in this Indenture or the Securities of each series or established
with respect to each series pursuant to Section 301 to the contrary notwithstanding. If (a) upon
the occurrence and continuance of an Event of Default specified in clause (1) or (2) of the
definition thereof, the Company and the Trustee receive notice in writing that Holders of not less
than 25%, or (b) upon the occurrence and continuance of any other Event of Default other than an
Event of Default specified in clause (1), (2), (5) and (6) of the definition thereof, the Company
and the Trustee receive notice in writing that Holders of not less than a majority in aggregate
principal amount of the Outstanding Notes of that series have declared the principal of all
Securities of that series to be due and payable immediately, then upon any such declaration the
same shall become and shall be immediately due and payable, anything contained in this Indenture or
in the Securities of that series or established with respect to that series to the contrary
notwithstanding.

     At any time after a declaration of acceleration or automatic acceleration with respect to the
Securities of any series has been made and before a judgment or decree for payment of the money due
has been obtained by the Trustee as hereafter in this Article Five provided, the Holders of not
less than a majority in principal amount of the Outstanding Securities of such

39

 

series, by written
notice to the Company and the Trustee, may rescind and annul the declaration or automatic
acceleration and its consequences if:

     (1) the Company has paid or deposited with the Trustee a sum of money sufficient to pay (A)
all overdue installments of interest on all Securities of such series and any Additional Amounts
payable with respect thereto, (B) the principal of and any premium on any Securities of the series
which have become due otherwise than by the declaration of acceleration or automatic acceleration
and interest thereon and any Additional Amounts with respect thereto at the rate or rates borne by
or provided in such Securities, (C) interest upon overdue interest at the rate or rates prescribed
therefor in such Securities and (D) all sums paid or advanced by the Trustee hereunder and the
reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and
counsel; and

     (2) all Events of Default with respect to Securities of such series, other than the
non-payment of the principal of, any premium and interest on, and any Additional Amounts with
respect to, Securities of such series which shall have become due solely by the acceleration, shall
have been cured or waived as provided in Section 513.

Section 503 Collection of Indebtedness and Suits for Enforcement by Trustee.

     The Company covenants that if

     (1) default is made in the payment of any installment of interest on any Security, or any
Additional Amounts payable with respect thereto, when such interest or Additional Amounts shall
have become due and payable and such default continues for any cure period specified with respect
to such Security,

     (2) default is made in the payment of any principal of or premium, if any, on, or any
Additional Amounts payable in respect of any principal of or premium, if any, on any Security at
its Maturity; or

     (3) default is made in the deposit of any sinking fund payment, when and as due by the terms
of any Security and such default continues for any cure period specified with respect to such
Security;

the Company shall, upon demand of the Trustee, pay to the Trustee, for the benefit of the Holders
of such Securities, the whole amount of money then due and payable with respect to such Securities,
with interest upon the overdue principal, any premium and, to the extent that payment of such
interest shall be legally enforceable, upon any overdue installments of interest and Additional
Amounts at the rate or rates borne by or provided for in such Securities, and, in addition thereto,
such further amount of money as shall be sufficient to cover the costs and expenses of collection,
including the reasonable compensation, expenses, disbursements and
advances of the Trustee, its agents and counsel and all other amounts due to the Trustee under
Section 607.

     If the Company fails to pay the money it is required to pay the Trustee pursuant to the
preceding paragraph forthwith upon the demand of the Trustee, the Trustee, in its own name and as
trustee of an express trust, may institute a judicial proceeding for the collection of the money

40

 

so
due and unpaid, and may prosecute such proceeding to judgment or final decree, and may enforce the
same against the Company or any other obligor upon such Securities and collect the monies adjudged
or decreed to be payable in the manner provided by law out of the property of the Company or any
other obligor upon such Securities, wherever situated.

     If an Event of Default with respect to the Securities of any series occurs and is continuing,
the Trustee may, and if (A) an Event of Default specified in clause (1), (2), (5) or (6) of the
definition thereof occurs and is continuing, and Holders of not less than 25%, or (B) an Event of
Default other than an Event of Default specified in clause (1), (2), (5) or (6) of the definition
thereof occurs and is continuing, and Holders of not less than a majority, in aggregate principal
amount of the Outstanding Securities of such series direct, so long as such Holders shall have
provided the Trustee with such indemnity as it shall require and subject to the provisions of
Section 512, the Trustee shall, proceed to protect and enforce its rights and the rights of the
Holders of Securities of such series by such appropriate judicial proceedings to protect and
enforce any such rights, whether for the specific enforcement of any covenant or agreement in this
Indenture or such Securities or in aid of the exercise of any power granted herein or therein, or
to enforce any other proper remedy.

Section 504 Trustee May File Proofs of Claim.

     In case of the pendency of any receivership, insolvency, liquidation, bankruptcy,
reorganization, arrangement, adjustment, composition or other judicial proceeding relative to the
Company or any other obligor upon the Securities or the property of the Company or such other
obligor or their creditors, the Trustee (irrespective of whether the principal of the Securities
shall then be due and payable as therein expressed or by declaration or otherwise and irrespective
of whether the Trustee shall have made any demand on the Company for the payment of any overdue
principal, premium, interest or Additional Amounts) shall be entitled and empowered, by
intervention in such proceeding or otherwise,

     (1) to file and prove a claim for the whole amount, or such lesser amount as may be provided
for in the Securities of such series, of the principal and any premium, interest and Additional
Amounts owing and unpaid in respect of the Securities and to file such other papers or documents as
may be necessary or advisable in order to have the claims of the Trustee (including any claim for
the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents or
counsel) and of the Holders of Securities allowed in such judicial proceeding, and

     (2) to collect and receive any monies or other property payable or deliverable on any such
claims and to distribute the same;

and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official
in any such judicial proceeding is hereby authorized by each Holder of Securities to make such
payments to the Trustee and, in the event that the Trustee shall consent to the making of such
payments directly to the Holders of Securities, to pay to the Trustee any amount due to it for the
reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and
counsel and any other amounts due the Trustee under Section 607.

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     Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to
or accept or adopt on behalf of any Holder of a Security any plan of reorganization, arrangement,
adjustment or composition affecting the Securities or the rights of any Holder thereof, or to
authorize the Trustee to vote in respect of the claim of any Holder of a Security in any such
proceeding.

Section 505 Trustee May Enforce Claims without Possession of Securities .

     All rights of action and claims under this Indenture or any of the Securities may be
prosecuted and enforced by the Trustee without the possession of any of the Securities or the
production thereof in any proceeding relating thereto, and any such proceeding instituted by the
Trustee shall be brought in its own name as trustee of an express trust, and any recovery or
judgment, after provision for the payment of the reasonable compensation, expenses, disbursements
and advances of the Trustee, its agents and counsel, shall be for the ratable benefit of each and
every Holder of a Security in respect of which such judgment has been recovered.

Section 506 Application of Money Collected.

     Any money collected by the Trustee pursuant to this Article Five with respect to Securities of
any series shall be applied in the following order, at the date or dates fixed by the Trustee and,
in case of the distribution of such money on account of principal, or any premium, interest or
Additional Amounts, upon presentation of such Securities, and the notation thereon of the payment
if only partially paid and upon surrender thereof if fully paid:

     FIRST: To the payment of all amounts due the Trustee and any predecessor Trustee under Section
607;

     SECOND: To the payment of the amounts then due and unpaid upon such Securities for principal
and any premium, interest and Additional Amounts in respect of which or for the benefit of which
such money has been collected, ratably, without preference or priority of any kind, according to
the aggregate amounts due and payable on such Securities for principal and any premium, interest
and Additional Amounts, respectively;

     THIRD: The balance, if any, to the Company.

Section 507 Limitations on Suits.

     No Holder of any Security of any series shall have any right to institute any proceeding,
judicial or otherwise, with respect to this Indenture, or for the appointment of a receiver or
trustee, or for any other remedy hereunder, unless

     (1) such Holder has previously given written notice to the Trustee of a continuing Event of
Default with respect to the Securities of such series;

     (2) (a) in the case of an Event of Default specified in clause (1), (2), (5) and (6) of the
definition thereof, Holders of not less than 25%, or (b) in the case of an Event of Default other
than as specified in clause (1), (2), (5) and (6) of the definition thereof, Holders of not less
than a majority, in aggregate principal amount of the Outstanding Securities of such series shall
have

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made written request to the Trustee to institute proceedings in respect of such Event of
Default in its own name as Trustee hereunder;

     (3) such Holder or Holders have offered to the Trustee indemnity satisfactory to it against
the costs, expenses and liabilities to be incurred in compliance with such request;

     (4) the Trustee for 60 days after its receipt of such notice, request and offer of indemnity
has failed to institute any such proceeding; and

     (5) no direction inconsistent with such written request has been given to the Trustee during
such 60-day period by the Holders of a majority in principal amount of the Outstanding Securities
of such series;

it being understood and intended that no one or more of such Holders shall have any right in any
manner whatever by virtue of, or by availing of, any provision of this Indenture or any Security to
affect, disturb or prejudice the rights of any other such Holders or Holders of Securities of any
other series, or to obtain or to seek to obtain priority or preference over any other Holders or to
enforce any right under this Indenture, except in the manner herein provided and for the equal and
ratable benefit of all such Holders.

Section 508 Unconditional Right of Holders to Receive Principal and any Premium, Interest and
Additional Amounts.

     Notwithstanding any other provision in this Indenture, the Holder of any Security shall have
the right, which is absolute and unconditional, to receive payment of the principal of, any premium
and (subject to Section 305 and Section 307) interest on, and any Additional Amounts with respect
to, such Security, on the respective Stated Maturity or Maturities therefor specified in such
Security (or, in the case of redemption, on the Redemption Date or, in the case of repayment at the
option of such Holder if provided in or pursuant to this Indenture, on the date such repayment is
due) and to institute suit for the enforcement of any such payment, and such right shall not be
impaired without the consent of such Holder.

Section 509 Restoration of Rights and Remedies.

     If the Trustee or any Holder of a Security has instituted any proceeding to enforce any right
or remedy under this Indenture and such proceeding has been discontinued or abandoned for any
reason, or has been determined adversely to the Trustee or to such Holder, then and in every such
case the Company, the Trustee and each such Holder shall, subject to any determination in such
proceeding, be restored severally and respectively to their former positions hereunder, and
thereafter all rights and remedies of the Trustee and each such Holder shall continue as though no
such proceeding had been instituted.

Section 510 Rights and Remedies Cumulative.

     Except as otherwise provided with respect to the replacement or payment of mutilated,
destroyed, lost or stolen Securities in the last paragraph of Section 306, no right or remedy
herein conferred upon or reserved to the Trustee or to each and every Holder of a Security is
intended to be exclusive of any other right or remedy, and every right and remedy, to the extent
permitted by

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law, shall be cumulative and in addition to every other right and remedy given
hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or
employment of any right or remedy hereunder, or otherwise, shall not, to the extent permitted by
law, prevent the concurrent assertion or employment of any other appropriate right or remedy.

Section 511 Delay or Omission Not Waiver.

     No delay or omission of the Trustee or of any Holder of any Security to exercise any right or
remedy accruing upon any Event of Default shall impair any such right or remedy or constitute a
waiver of any such Event of Default or an acquiescence therein. Every right and remedy given by
this Article Five or by law to the Trustee or to any Holder of a Security may be exercised from
time to time, and as often as may be deemed expedient, by the Trustee or by such Holder, as the
case may be.

Section 512 Control by Holders of Securities.

     The Holders of a majority in principal amount of the Outstanding Securities of any series
shall have the right to direct the time, method and place of conducting any proceeding for any
remedy available to the Trustee or exercising any trust or power conferred on the Trustee with
respect to the Securities of such series, provided that

     (1) such direction shall not be in conflict with any rule of law or with this Indenture or
with the Securities of any series and would not involve the Trustee in personal liability,

     (2) the Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction, and

     (3) such direction is not unduly prejudicial to the rights of the other Holders of Securities
of such series not joining in such action.

Section 513 Waiver of Past or Existing Defaults.

     The Holders of not less than a majority in principal amount of the Outstanding Securities of
any series on behalf of the Holders of all the Securities of such series may waive any past or
existing default or Event of Default hereunder with respect to such series and its consequences,
except a continuing default

     (1) in the payment of the principal of, any premium or interest on, or any Additional Amounts
with respect to, any Security of such series, or

     (2) in respect of a covenant or provision hereof which under Article Nine hereof cannot be
modified or amended without the consent of the Holder of each Outstanding Security of such series
affected.

     Upon any such waiver, such default or Event of Default shall cease to exist, and any Event of
Default arising therefrom shall be deemed to have been cured, for every purpose of this Indenture;
but no such waiver shall extend to any subsequent or other default or impair any right consequent
thereon.

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Section 514 Waiver of Stay or Extension Laws.

     The Company covenants that (to the extent that it may lawfully do so) it will not at any time
insist upon, or plead, or in any manner whatsoever claim or take the benefit or advantage of, any
stay or extension law wherever enacted, now or at any time hereafter in force, which may affect the
covenants or the performance of this Indenture; and the Company expressly waives (to the extent
that it may lawfully do so) all benefit or advantage of any such law and covenants that it will not
hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer
and permit the execution of every such power as though no such law had been enacted.

Section 515 Undertaking for Costs.

     All parties to this Indenture agree, and each Holder of any Security by his acceptance thereof
shall be deemed to have agreed, that any court may in its discretion require, in any suit for the
enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any
action taken or omitted by it as Trustee, the filing by any party litigant in such suit of any
undertaking to pay the costs of such suit, and that such court may in its discretion assess
reasonable costs, including reasonable attorneys’ fees and expenses, against any party litigant in
such suit having due regard to the merits and good faith of the claims or defenses made by such
party litigant; but the provisions of this Section 515 shall not apply to any suit instituted by
the Trustee, to any suit instituted by any Holder, or group of Holders, holding in the aggregate
more than 10% in principal amount of Outstanding Securities of any series, or to any suit
instituted by any Holder for the enforcement of the payment of the principal of (or premium, if
any) or interest, if any, on or Additional Amounts, if any, with respect to any Security on or
after the respective Stated Maturities expressed in such Security (or, in the case of redemption,
on or after the Redemption Date, and, in the case of repayment, on or after the date for repayment)
or for the enforcement of the right, if any, to convert or exchange any Security into Common Stock
or other securities, cash or other property in accordance with its terms.

ARTICLE SIX

THE TRUSTEE

Section 601 Certain Duties and Responsibilities.

     The duties and responsibilities of the Trustee shall be as provided by the Trust Indenture
Act. Except during the continuance of an Event of Default with respect to the Securities of a
series of which a Responsible Officer has actual knowledge, the Trustee undertakes to perform
such duties and only such duties as are specifically set forth in this Indenture with respect to
such Securities, and no implied covenants or obligations shall be read into this Indenture with
respect to such Securities against the Trustee. In case an Event of Default of which a Responsible
Officer has actual knowledge with respect to the Securities of a series has occurred (which has not
been cured or waived), the Trustee shall exercise the rights and powers vested in it by this
Indenture, and use the same degree of care and skill in their exercise, with respect to such
Securities, as a prudent person would exercise or use under the circumstances in the conduct of
such person’s own affairs. Notwithstanding the foregoing, no provision of this Indenture shall

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require the Trustee to expend or risk its own funds or otherwise incur any financial liability in
the performance of any of its duties hereunder, or in the exercise of any of its rights or powers.
Whether or not therein expressly so provided, every provision of this Indenture relating to the
conduct or affecting the liability of or affording protection to the Trustee shall be subject to
the provisions of this Section 601.

Section 602 Certain Rights of Trustee.

     Subject to the provisions of Section 601:

     (1) the Trustee may conclusively rely and shall be fully protected in acting or refraining
from acting upon any resolution, certificate, statement, instrument, opinion, report, notice,
request, direction, consent, order, bond, debenture, note, coupon, other evidence of indebtedness
or other paper or document (whether in its original or facsimile form) believed by it to be genuine
and to have been signed or presented by the proper party or parties;

     (2) any request or direction of the Company mentioned herein shall be sufficiently evidenced
by a Company Request or a Company Order (in each case, other than delivery of any Security to the
Trustee for authentication and delivery pursuant to Section 303 which shall be sufficiently
evidenced as provided therein) and any resolution of the Board of Directors of the Company may be
sufficiently evidenced by a Board Resolution;

     (3) whenever in the administration of this Indenture the Trustee shall deem it desirable that
a matter be proved or established prior to taking, suffering or omitting any action hereunder, the
Trustee (unless other evidence shall be herein specifically prescribed) may, in the absence of bad
faith on its part, request and conclusively rely upon an Officer’s Certificate;

     (4) the Trustee may consult with counsel of its selection and the advice of such counsel or
any Opinion of Counsel shall be full and complete authorization and protection in respect of any
action taken, suffered or omitted by it hereunder in good faith and in reliance thereon;

     (5) the Trustee shall be under no obligation to exercise any of the rights or powers vested in
it by or pursuant to this Indenture or to institute, conduct or defend any litigation hereunder or
in relation hereto at the request or direction of any of the Holders of Securities of any series
pursuant to this Indenture, unless such Holders shall have offered to the Trustee security or
indemnity reasonably satisfactory to it against the costs, expenses and liabilities which might be
incurred by it in compliance with such request or direction;

     (6) the Trustee shall not be bound to make any investigation into the facts or matters stated
in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction,
consent, order, bond, debenture, coupon, note, other evidence of indebtedness or other paper or
document, but the Trustee, in its discretion, may but shall not be obligated to make such further
inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee shall
determine to make such further inquiry or investigation, it shall be entitled to examine, during
business hours and upon reasonable notice, the books, records and premises of the Company,
personally or by agent or attorney at the expense of the Company and shall incur no liability or
additional liability of any kind by reason of such inquiry or investigation;

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     (7) the Trustee may execute any of the trusts or powers hereunder or perform any duties
hereunder either directly or by or through agents, attorneys or custodians and the Trustee shall
not be responsible for any misconduct or negligence on the part of any agent, attorney or
custodians appointed with due care by it hereunder;

     (8) the Trustee shall not be liable in its individual capacity for any action taken or
suffered to be taken, unless it shall be proved that the Trustee was negligent, acted in bad faith
or engaged in willful misconduct;

     (9) the Authenticating Agent, Paying Agent, and Security Registrar shall have the same
protections as the Trustee set forth hereunder;

     (10) the Trustee shall not be liable in its individual capacity with respect to any action
taken, suffered or omitted to be taken by it in good faith in accordance with this Indenture, and,
to the extent not so provided herein, with respect to any act requiring the Trustee to exercise its
own discretion, relating to the time, method and place of conducting any proceeding for any remedy
available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this
Indenture or any Securities, unless it shall be proved that, in connection with any such action
taken, suffered or omitted or any such act, the Trustee was negligent, acted in bad faith or
engaged in willful misconduct;

     (11) no provision of this Indenture shall require the Trustee to expend or risk its own funds
or otherwise incur any financial liability in the performance of any of its duties hereunder, or in
the exercise of any of its rights or powers;

     (12) the Trustee shall not be charged with knowledge or required to take notice of any default
or Event of Default with respect to the Securities unless either (A) a Responsible Officer shall
have actual knowledge of such default or Event of Default or (B) written notice of such default or
Event of Default, which references the Securities and this Indenture, shall have been given to a
Responsible Officer by the Company or other obligor on such Securities or by any Holder of such
Securities;

     (13) the Trustee shall not be liable in its individual capacity for any action taken, suffered
or omitted by it in good faith and reasonably believed by it to be authorized or within the
discretion or rights or powers conferred upon it by this Indenture;

     (14) the rights, privileges, protections, immunities and benefits given to the Trustee,
including, without limitation, its right to be indemnified, are extended to, and shall be
enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian,
director, officer, employee and other Person employed to act hereunder;

     (15) the Trustee may request that the Company deliver an Officer’s Certificate setting forth
the names of individuals and/or titles of Officers authorized at such time to take specified
actions pursuant to this Indenture, which Officer’s Certificate may be signed by any person
authorized to sign an Officer’s Certificate, including any person specified as so authorized in any
such certificate previously delivered and not superseded;

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     (16) the permissive rights of the Trustee to take certain actions under or perform any
discretionary act enumerated in this Indenture shall not be construed as a duty unless so specified
herein, and the Trustee shall not be answerable for other than its negligence or willful misconduct
in the performance of such action or act;

     (17) the Trustee shall not be liable in its individual capacity with respect to any action
taken, suffered or omitted to be taken by it in good faith in accordance with this Indenture or at
the direction of the Holders of a majority in aggregate principal amount of the Outstanding
Securities relating to the time, method and place of conducting any proceeding for any remedy
available to the Trustee, or exercising or omitting to exercise any trust or power conferred upon
the Trustee, under this Indenture;

     (18) in no event shall the Trustee be liable for special, indirect or consequential loss or
damage of any kind whatsoever (including but not limited to lost profits) even if the Trustee has
been advised of the likelihood of such loss or damage and regardless of the form of action; and

     (19) in no event shall the Trustee be responsible or liable for any failure or delay in the
performance of its obligations hereunder arising out of or caused by, directly or indirectly,
forces beyond its control, including, without limitation strikes, work stoppages, accidents, acts
of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of
God, and interruptions, loss or malfunctions of utilities, communications or computer (software and
hardware) services; it being understood that the Trustee shall use reasonable efforts which are
consistent with accepted practices in the banking industry to resume performance as soon as
practicable under the circumstances.

Section 603 Notice of Defaults.

     Within 90 days after the occurrence of any default hereunder with respect to the Securities of
any series of which a Responsible Officer has actual knowledge, the Trustee shall give the Holders
of Securities of such series entitled to receive reports pursuant to Section 703, notice of such
default hereunder actually known to a Responsible Officer, unless such default shall have been
cured or waived; provided, however, that, except in the case of a default in the payment of the
principal of (or premium, if any), or interest, if any, on, or Additional Amounts or any sinking
fund or purchase fund installment with respect to, any Security of such series, the Trustee shall
be protected in withholding such notice if and so long as the board of directors, the executive
committee or a trust committee of directors and/or Responsible Officers in good faith
determine that the withholding of such notice is in the best interest of the Holders of
Securities of such series; and provided, further, that in the case of any default of the character
specified in Section 501(4) with respect to Securities of such series, no such notice to Holders
shall be given until at least 30 days after the occurrence thereof. For the purpose of this
Section, the term “default” means any event which is, or after notice or lapse of time or
both would become, an Event of Default with respect to Securities of such series.

Section 604 Not Responsible for Recitals or Issuance of Securities.

     The recitals contained herein and in the Securities, except the Trustee’s certificate of
authentication, shall be taken as the statements of the Company, and neither the Trustee nor any

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Authenticating Agent assumes any responsibility for their correctness. The Trustee makes no
representations as to the validity, sufficiency or priority of this Indenture or of the Securities.
Neither the Trustee nor any Authenticating Agent shall be accountable for the use or application
by the Company of the Securities or the proceeds thereof. Except with respect to the
authentication of Securities pursuant to Section 303, the Trustee shall not be responsible for the
legality or the validity of this Indenture or any Securities issued or to be issued hereunder.

Section 605 May Hold Securities.

     The Trustee, any Authenticating Agent, any Paying Agent, any Security Registrar or any other
Person that may be an agent of the Trustee or the Company, in its individual or any other capacity,
may become the owner or pledgee of Securities and, subject to Sections 310(b) and 311 of the Trust
Indenture Act, may otherwise deal with the Company with the same rights it would have if it were
not the Trustee, Authenticating Agent, Paying Agent, Security Registrar or such other Person.

Section 606 Money Held in Trust.

     Money held by the Trustee in trust hereunder need not be segregated from other funds except to
the extent required by law. The Trustee shall be under no liability for interest on any money
received by it hereunder except as otherwise agreed in writing with the Company.

Section 607 Compensation and Reimbursement.

     The Company agrees:

     (1) to pay to the Trustee from time to time such compensation as shall be agreed upon from
time to time in writing between the Company and the Trustee for all services rendered by the
Trustee hereunder (which compensation shall not be limited by any provision of law in regard to the
compensation of a trustee of an express trust);

     (2) except as otherwise expressly provided herein, to reimburse the Trustee upon its request
for all reasonable expenses, disbursements and advances incurred or made by the Trustee in
accordance with any provision of this Indenture arising out of or in connection with the acceptance
or administration of the trust or trusts hereunder (including the reasonable compensation and the
expenses and disbursements of its agents and counsel), except any such
expense, disbursement or advance as may be caused by the Trustee’s own negligence or willful
misconduct; and

     (3) to fully indemnify each of the Trustee and any predecessor Trustee and its agents,
officers, directors and employees for, and to hold them harmless against, any loss, liability,
damage, claim or expense (including reasonable legal fees and expenses), including taxes (other
than taxes based on the income of the Trustee), incurred without negligence or willful misconduct
on their part, arising out of or in connection with the acceptance or administration of the trust
or trusts hereunder, including the reasonable costs and expenses of defending themselves against
any claim or liability (whether asserted by the Company, a Holder of Securities, or any other
Person) in connection with the exercise or performance of any of their powers or duties hereunder.

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     As security for the performance of the payment obligations of the Company under this Section
606, the Trustee shall have a lien prior to the Securities of any series upon all property and
funds held or collected by the Trustee as such, except funds held in trust for the payment of
principal of, and premium or interest on, or any Additional Amounts with respect to, particular
Securities. Such lien shall survive the resignation or removal of the Trustee and the satisfaction
and discharge of this Indenture. Without prejudice to any other rights available to the Trustee
under applicable law, when the Trustee incurs expenses or renders services after a default or Event
of Default specified in Section 501(5) and 501(6) hereof occurs, the expenses and the compensation
for the services (including the fees and expense of its agents and counsel) are intended to
constitute expense of administration under U.S. Code, Title 11 or any other similar foreign,
federal or state law for the relief of debtors.

     Without prejudice to any other rights available to the Trustee under applicable law, to the
extent permitted by law any compensation or expense incurred by the Trustee after a default
specified in or pursuant to Section 501 is intended to constitute an expense of administration
under any then applicable bankruptcy or insolvency law. “Trustee” for purposes of this
Section 607 shall include any predecessor Trustee but the negligence or willful misconduct of any
Trustee shall not affect the rights of any other Trustee under this Section 607.

     Notwithstanding any other provision of this Indenture to the contrary, in no event shall the
Trustee be liable for special, indirect or consequential damages of any kind whatsoever (including
but not limited to lost profits) even if the Trustee had been advised of the likelihood of such
loss or damage and regardless of the form of action.

     The provisions of this Section 607 shall survive the satisfaction and discharge of this
Indenture or the earlier resignation or removal of the Trustee and shall apply with equal force and
effect to the Trustee in its capacity as Authenticating Agent, Paying Agent or Security Registrar.

Section 608 Corporate Trustee Required; Eligibility; Conflicting Interests.

     There shall at all times be a Trustee hereunder that is a Corporation or a national banking
association, organized and doing business under the laws of the United States of America, any state
thereof or the District of Columbia, eligible under Section 310(a)(1) of the Trust Indenture
Act to act as trustee under an indenture qualified under the Trust Indenture Act and that has
a combined capital and surplus (computed in accordance with Section 310(a)(2) of the Trust
Indenture Act) of at least $50,000,000 subject to supervision or examination by federal or state
authority. If at any time the Trustee shall cease to be eligible in accordance with the provisions
of this Section 608, it shall resign immediately in the manner and with the effect hereinafter
specified in this Article Six.

     If the Trustee has or shall acquire a conflicting interest within the meaning of the Trust
Indenture Act, the Trustee shall either eliminate such interest or resign, to the extent and in the
manner provided by, and subject to the provisions of, the Trust Indenture Act and this Indenture.
To the extent permitted by such Act, the Trustee shall not be deemed to have a conflicting interest
by virtue of being a trustee under this Indenture with respect to Securities of more than one
series or by virtue of being trustee under the Senior Indenture dated as of July 19, 1990,

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between
the Company and the Trustee, the Senior Indenture dated as of February 1, 1996, between the Company
and the Trustee, the Senior Indenture dated as of February 25, 1997, between the Company and the
Trustee, the Senior Indenture dated as of November 10, 1997, between the Company and the Trustee,
the Indenture dated as of May 28, 2003 between the Company and the Trustee, and the Indenture dated
as of March 5, 2009 between the Company and the Trustee.

Section 609 Resignation and Removal; Appointment of Successor.

     (1) No resignation or removal of the Trustee and no appointment of a successor Trustee
pursuant to this Article Six shall become effective until the acceptance of appointment by the
successor Trustee pursuant to Section 610.

     (2) The Trustee may resign at any time with respect to the Securities of one or more series by
giving written notice thereof to the Company. If the instrument of acceptance by a successor
Trustee required by Section 610 shall not have been delivered to the Trustee within 30 days after
the giving of such notice of resignation, the resigning Trustee may petition, at the expense of the
Company, any court of competent jurisdiction for the appointment of a successor Trustee with
respect to such series.

     (3) The Trustee may be removed at any time with respect to the Securities of any series by Act
of the Holders of a majority in principal amount of the Outstanding Securities of such series,
delivered to the Trustee and the Company. If the instrument of acceptance by a successor Trustee
required by Section 610 shall not have been delivered to the Trustee within 30 days after the
giving of such notice of removal, the Trustee being removed may petition, at the expense of the
Company, any court of competent jurisdiction for the appointment of a successor Trustee with
respect to such series. The Trustee for one or more series of Securities may be removed by the
Company, so long as no default or Event of Default has occurred and is continuing with respect to
such series.

     (4) If at any time:

     (a) the Trustee shall fail to comply with the obligations imposed upon it under Section
310(b) of the Trust Indenture Act with respect to Securities of any series after
written request therefor by the Company or any Holder of a Security of such series who
has been a bona fide Holder of a Security of such series for at least six months, or

     (b) the Trustee shall cease to be eligible under Section 608 and shall fail to resign
after written request therefor by the Company or any such Holder, or

     (c) the Trustee shall become incapable of acting or shall be adjudged a bankrupt or
insolvent or a receiver of the Trustee or of its property shall be appointed or any public
officer shall take charge or control of the Trustee or of its property or affairs for the
purpose of rehabilitation, conservation or liquidation,

     then, in any such case,

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	 	(ii)	 	the Company, by or pursuant to a Company Order, may remove the
Trustee with respect to all Securities or the Securities of such series, or
	 
	 	(iii)	 	subject to Section 515, any Holder of a Security who has been
a bona fide Holder of a Security of such series for at least six months may, on
behalf of himself and all others similarly situated, petition any court of
competent jurisdiction for the removal of the Trustee with respect to all
Securities of such series and the appointment of a successor Trustee or
Trustees.

     (5) If the Trustee shall resign, be removed or become incapable of acting, or if a vacancy
shall occur in the office of Trustee for any cause, with respect to the Securities of one or more
series, the Company, by or pursuant to a Company Order, shall promptly appoint a successor Trustee
or Trustees with respect to the Securities of such series (it being understood that any such
successor Trustee may be appointed with respect to the Securities of one or more or all of such
series and that at any time there shall be only one Trustee with respect to the Securities of any
particular series) and shall comply with the applicable requirements of Section 610. If, within
one year after such resignation, removal or incapacity, or the occurrence of such vacancy, a
successor Trustee with respect to the Securities of any series shall be appointed by Act of the
Holders of a majority in principal amount of the Outstanding Securities of such series delivered to
the Company and the retiring Trustee, the successor Trustee so appointed shall, forthwith upon its
acceptance of such appointment in accordance with the applicable requirements of Section 610,
become the successor Trustee with respect to the Securities of such series and to that extent
supersede the successor Trustee appointed by the Company. If no successor Trustee with respect to
the Securities of any series shall have been so appointed by the Company or the Holders of
Securities and accepted appointment in the manner required by Section 610, any Holder of a Security
who has been a bona fide Holder of a Security of such series for at least six months may, on behalf
of himself and all others similarly situated, petition any court of competent jurisdiction for the
appointment of a successor Trustee with respect to the Securities of such series.

     (6) The Company shall give notice of each resignation and each removal of the Trustee with
respect to the Securities of any series and each appointment of a successor Trustee with respect to
the Securities of any series by mailing written notice of such event by first-class mail, postage
prepaid, to the Holders of Registered Securities, if any, of such series as their names and
addresses appear in the Security Register. Each notice shall include the name of the
successor Trustee with respect to the Securities of such series and the address of its Corporate
Trust Office.

     (7) In no event shall any retiring Trustee be liable for the acts or omissions of any
successor Trustee hereunder.

Section 610 Acceptance of Appointment by Successor.

     (1) Upon the appointment hereunder of any successor Trustee with respect to all Securities,
such successor Trustee so appointed shall execute, acknowledge and deliver to the Company and the
retiring Trustee an instrument accepting such appointment, and thereupon the resignation or removal
of the retiring Trustee shall become effective and such successor Trustee, without any further act,
deed or conveyance, shall become vested with all the rights, powers,

52

 

trusts and duties hereunder of
the retiring Trustee; but, on the request of the Company or such successor Trustee, such retiring
Trustee, upon payment of its charges, shall execute and deliver an instrument transferring to such
successor Trustee all the rights, powers and trusts of the retiring Trustee and, subject to Section
1003, shall duly assign, transfer and deliver to such successor Trustee all property and money held
by such retiring Trustee hereunder, subject nevertheless to its lien, if any, provided for in
Section 607.

     (2) Upon the appointment hereunder of any successor Trustee with respect to the Securities of
one or more (but not all) series, the Company, the retiring Trustee and such successor Trustee
shall execute and deliver an indenture supplemental hereto wherein each successor Trustee shall
accept such appointment and which (1) shall contain such provisions as shall be necessary or
desirable to transfer and confirm to, and to vest in, such successor Trustee all the rights,
powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those
series to which the appointment of such successor Trustee relates, (2) if the retiring Trustee is
not retiring with respect to all Securities, shall contain such provisions as shall be deemed
necessary or desirable to confirm that all the rights, powers, trusts and duties of the retiring
Trustee with respect to the Securities of that or those series as to which the retiring Trustee is
not retiring shall continue to be vested in the retiring Trustee and (3) shall add to or change any
of the provisions of this Indenture as shall be necessary to provide for or facilitate the
administration of the trusts hereunder by more than one Trustee, it being understood that nothing
herein or in such supplemental indenture shall constitute such Trustees co-trustees of the same
trust, that each such Trustee shall be trustee of a trust or trusts hereunder separate and apart
from any trust or trusts hereunder administered by any other such Trustee and that no Trustee shall
be responsible for any notice given to, or received by, or any act or failure to act on the part of
any other Trustee hereunder, and, upon the execution and delivery of such supplemental indenture,
the resignation or removal of the retiring Trustee shall become effective to the extent provided
therein, such retiring Trustee shall have no further responsibility for the exercise of rights and
powers or for the performance of the duties and obligations vested in the Trustee under this
Indenture with respect to the Securities of that or those series to which the appointment of such
successor Trustee relates other than as hereinafter expressly set forth, and such successor
Trustee, without any further act, deed or conveyance, shall become vested with all the rights,
powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those
series to which the appointment of such successor Trustee relates; but, on request of the Company
or such successor Trustee, such retiring Trustee, upon payment of its charges with
respect to the Securities of that or those series to which the appointment of such successor
Trustee relates and subject to Section 1003 shall duly assign, transfer and deliver to such
successor Trustee, to the extent contemplated by such supplemental indenture, the property and
money held by such retiring Trustee hereunder with respect to the Securities of that or those
series to which the appointment of such successor Trustee relates, subject to its lien, if any,
provided for in Section 607.

     (3) Upon request of any Person appointed hereunder as a successor Trustee, the Company shall
execute any and all instruments for more fully and certainly vesting in and confirming to such
successor Trustee all such rights, powers and trusts.

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     (4) No Person shall accept its appointment hereunder as a successor Trustee unless at the time
of such acceptance such successor Person shall be qualified and eligible under this Article Six.

Section 611 Merger, Conversion, Consolidation or Succession to Business.

     Any Corporation or national banking association into which the Trustee may be merged or
converted or with which it may be consolidated, or any Corporation or national banking association
resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or
any Corporation or national banking association succeeding to all or substantially all of the
corporate trust business of the Trustee by sale or otherwise, shall be the successor of the Trustee
hereunder, provided such Corporation or national banking association shall otherwise be qualified
and eligible under this Article Six, in each case without the execution or filing of any paper or
any further act on the part of any of the parties hereto. In case any Securities shall have been
authenticated but not delivered by the Trustee then in office, any successor by merger, conversion
or consolidation to such authenticating Trustee may adopt such authentication and deliver the
Securities so authenticated with the same effect as if such successor Trustee had itself
authenticated such Securities.

Section 612 Appointment of Authenticating Agent.

     The Trustee may appoint one or more Authenticating Agents acceptable to the Company with
respect to one or more series of Securities which shall be authorized to act on behalf of the
Trustee to authenticate Securities of that or those series issued upon original issue, exchange,
registration of transfer, partial redemption or partial repayment or pursuant to Section 306, and
Securities so authenticated shall be entitled to the benefits of this Indenture and shall be valid
and obligatory for all purposes as if authenticated by the Trustee hereunder. Wherever reference
is made in this Indenture to the authentication and delivery of Securities by the Trustee or the
Trustee’s certificate of authentication, such reference shall be deemed to include authentication
and delivery on behalf of the Trustee by an Authenticating Agent and a certificate of
authentication executed on behalf of the Trustee by an Authenticating Agent.

     Each Authenticating Agent must be acceptable to the Company and, except as provided in or
pursuant to this Indenture, shall at all times be a Corporation or national banking association
that would be permitted by the Trust Indenture Act to act as trustee under an indenture qualified
under the Trust Indenture Act, is authorized under applicable law and by its
charter to act as an Authenticating Agent and has a combined capital and surplus (computed in
accordance with Section 310(a)(2) of the Trust Indenture Act) of at least $50,000,000. If at any
time an Authenticating Agent shall cease to be eligible in accordance with the provisions of this
Section 612, it shall resign immediately in the manner and with the effect specified in this
Section 612.

     Any Corporation or national banking association into which an Authenticating Agent may be
merged or converted or with which it may be consolidated, or any Corporation or national banking
association resulting from any merger, conversion or consolidation to which such Authenticating
Agent shall be a party, or any Corporation or national banking association succeeding to all or
substantially all of the corporate agency or corporate trust business of an

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Authenticating Agent,
shall be the successor of such Authenticating Agent hereunder, provided such Corporation or
national banking association shall be otherwise eligible under this Section 612, without the
execution or filing of any paper or any further act on the part of the Trustee or the
Authenticating Agent.

     An Authenticating Agent may resign at any time by giving written notice thereof to the Trustee
and the Company. The Trustee may at any time terminate the agency of an Authenticating Agent by
giving written notice thereof to such Authenticating Agent and the Company. Upon receiving such a
notice of resignation or upon such a termination, or in case at any time such Authenticating Agent
shall cease to be eligible in accordance with the provisions of this Section 612, the Trustee may
appoint a successor Authenticating Agent which shall be acceptable to the Company and shall mail
written notice of such appointment by first-class mail, postage prepaid, to all Holders of
Registered Securities, if any, of the series with respect to which such Authenticating Agent shall
serve, as their names and addresses appear in the Security Register. Any successor Authenticating
Agent, upon acceptance of its appointment hereunder, shall become vested with all the rights,
powers and duties of its predecessor hereunder, with like effect as if originally named as an
Authenticating Agent. No successor Authenticating Agent shall be appointed unless eligible under
the provisions of this Section 612.

     The Company agrees to pay each Authenticating Agent from time to time reasonable compensation
for its services under this Section 612 to the extent agreed in writing.

     The provisions of Section 303, Section 601, Section 604 and Section 605 shall be applicable to
each Authenticating Agent.

     If an Authenticating Agent is appointed with respect to one or more series of Securities
pursuant to this Section 612, the Securities of such series may have endorsed thereon, in addition
to or in lieu of the Trustee’s certificate of authentication, an alternate certificate of
authentication in substantially the following form:

     This is one of the Securities of the series designated therein referred to in the
within-mentioned Indenture.

55

 

	 	 	 	 	 
	 	THE BANK OF NEW YORK MELLON
TRUST COMPANY, N.A.,

As Trustee

 	 
	 	By:  	 	 
	 	 	As Authenticating Agent 	 
	 	 	 	 
	 	 	 
	 	By:  	
 	 
	 	 	Authorized Officer 

	 
	 	Dated:
	 
	 

     If all of the Securities of any series may not be originally issued at one time, and if the
Trustee does not have an office capable of authenticating Securities upon original issuance located
in a Place of Payment where the Company wishes to have Securities of such series authenticated upon
original issuance, the Trustee, if so requested by Company Request (which writing need not be
accompanied by or contained in an Officer’s Certificate), shall appoint in accordance with this
Section 612 (and subject to such procedures as shall be acceptable to the Trustee) an
Authenticating Agent having an office in a Place of Payment designated by the Company with respect
to such series of Securities.

ARTICLE SEVEN

HOLDERS LISTS AND REPORTS BY TRUSTEE AND COMPANY

Section 701 Company to Furnish Trustee Names and Addresses of Holders.

     In accordance with Section 312(a) of the Trust Indenture Act, the Company shall furnish or
cause to be furnished to the Trustee

     (1) semi-annually with respect to Securities of each series not later than 15 days after each
Regular Record Date in respect of Securities of a series, a list, in each case in such form as the
Trustee may reasonably require, of the names and addresses of Holders of such Securities as of the
applicable date, and

     (2) at such other times as the Trustee may request in writing, within 30 days after the
receipt by the Company of any such request, a list of similar form and content as of a date not
more than 15 days prior to the time such list is furnished,

provided, however, that so long as the Trustee is the Security Registrar no such list shall be
required to be furnished.

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Section 702 Preservation of Information; Communications to Holders.

     The Trustee shall comply with the obligations imposed upon it pursuant to Section 312 of the
Trust Indenture Act.

     Every Holder of Securities, by receiving and holding the same, agrees with the Company and the
Trustee that neither the Company, the Trustee, any Paying Agent or any Security Registrar shall be
held accountable by reason of the disclosure of any such information as to the names and addresses
of the Holders of Securities in accordance with Section 312 of the Trust Indenture Act, regardless
of the source from which such information was derived, and that the Trustee shall not be held
accountable by reason of mailing any material pursuant to a request made under Section 312(b) of
the Trust Indenture Act.

Section 703 Reports by Trustee.

     (1) Within 60 days after May 15 of each year commencing with the first May 15 following the
first issuance of Securities pursuant to Section 301, if required by Section 313(a) of the Trust
Indenture Act, the Trustee shall transmit, pursuant to Section 313(c) of the Trust Indenture Act, a
brief report dated as of such May 15 with respect to any of the events specified in said Section
313(a) which may have occurred since the later of the immediately preceding May 15 and the date of
this Indenture.

     (2) The Trustee shall transmit any reports required by Section 313(a) of the Trust Indenture
Act at the times specified therein.

     (3) A copy of each report, if any, described in Section 703(1) and (2) shall, at the time of
such transmission to Holders, be filed by the Trustee with each stock exchange, if any, upon which
the Securities are listed, with the Commission and with the Company. The Company will promptly
notify the Trustee when the Securities are listed on any stock exchange and of any delisting
thereof.

Section 704 Reports by Company.

     The Company, pursuant to Section 314(a) of the Trust Indenture Act, shall:

     (1) file with the Trustee, within 30 days after the Company has filed the same with the
Commission, unless such reports are available on the Commission’s EDGAR filing system (or any
successor thereto), copies of the annual reports and of the information, documents and other
reports (or copies of such portions of any of the foregoing as the Commission may from time to time
by rules and regulations prescribe) which the Company may be required to file with the Commission
pursuant to Section 13 or Section 15(d) of the Exchange Act; or, if the Company is not required to
file information, documents or reports pursuant to either of Section 13 or Section 15(d) of the
Exchange Act, then it shall file with the Trustee and the Commission, in accordance with rules and
regulations prescribed from time to time by the Commission, such of the supplementary and periodic
information, documents and reports which may be required pursuant to Section 13 of the Exchange Act
in respect of a security listed and registered on a national securities exchange as may be
prescribed from time to time in such rules and regulations.

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     (2) file with the Trustee and the Commission, in accordance with rules and regulations
prescribed from time to time by the Commission, such additional information, documents and reports
with respect to compliance by the Company with the conditions and covenants of this Indenture as
may be required from time to time by such rules and regulations; and

     (3) transmit within 30 days after the filing thereof with the Trustee, in the manner and to
the extent provided in Section 313(c) of the Trust Indenture Act, such summaries of any
information, documents and reports required to be filed by the Company pursuant to paragraphs (1)
and (2) of this Section 704 as may be required by rules and regulations prescribed from time to
time by the Commission.

     Delivery of such reports, information and documents to the Trustee is for informational
purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any
information contained therein or determinable from information contained therein, including the
Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to
rely exclusively on Officer’s Certificates).

ARTICLE EIGHT

CONSOLIDATION, MERGER AND SALES

Section 801 Company May Consolidate, etc., Only on Certain Terms.

     The Company shall not directly or indirectly consolidate with or merge with or into, or sell,
assign, transfer, lease, convey or otherwise dispose of all or substantially all of its assets and
properties and the assets and properties of its Subsidiaries (taken as a whole) to another Person
in one or more related transactions unless:

     (1) either: (A) the Company is the survivor; or (B) the Person formed by or surviving any such
consolidation or merger (if other than the Company) or to which such sale, assignment, transfer,
lease, conveyance or other disposition has been made is a Person organized or existing under the
laws of the United States, any state of the United States or the District of Columbia;

     (2) the Person formed by or surviving any such consolidation or merger (if other than the
Company) or the Person to which such sale, assignment, transfer, lease, conveyance or other
disposition has been made shall expressly assume, by an indenture (or indentures, if at such time
there is more than one Trustee) supplemental hereto, in form reasonably satisfactory to the
Trustee, executed by the successor Person and delivered to the Trustee, the due and punctual
payment of the principal of, any premium and interest on and any Additional Amounts with respect
to, all the Securities and the performance of every obligation in this Indenture and the
Outstanding Securities on the part of the Company to be performed or observed and shall provide for
conversion or exchange rights in accordance with the provisions of the Securities of any series
that are convertible or exchangeable into Common Stock or other securities, cash or other property;

     (3) either the Company or the successor Person shall have delivered to the Trustee an
Officer’s Certificate and an Opinion of Counsel, each stating that such consolidation, merger,

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sale, assignment, transfer, lease, conveyance or other disposition and, if a supplemental
indenture is required in connection with such transaction, such supplemental indenture comply with
this Article Eight and that all conditions precedent herein provided for relating to such
transaction have been complied with; and

     (4) immediately after giving effect to such transaction, no Event of Default or event which,
after notice or lapse of time, or both, would become an Event of Default, shall have occurred and
be continuing.

Section 802 Successor Person Substituted for Company.

     Upon any consolidation by the Company with or merger of the Company into any other Person or
Persons where the Company is not the survivor or any sale, assignment, transfer, lease, conveyance
or other disposition of all or substantially all of the properties and assets of the Company and
the properties and assets of its Subsidiaries (taken as a whole) to any Person or Persons in
accordance with Section 801, the successor Person formed by such consolidation or into which the
Company is merged or to which such sale, assignment, transfer, lease, conveyance or other
disposition is made shall succeed to, and be substituted for, and may exercise every right and
power of, the Company under this Indenture with the same effect as if such successor Person had
been named as the Company herein; and thereafter, except in the case of a lease, the predecessor
Person shall be released from all obligations and covenants under this Indenture and the
Securities.

ARTICLE NINE

SUPPLEMENTAL INDENTURES

Section 901 Supplemental Indentures without Consent of Holders.

     Without the consent of any Holders of Securities, the Company (when authorized by or pursuant
to a Board Resolution) and the Trustee, at any time and from time to time, may enter into one or
more indentures supplemental hereto, in form satisfactory to the Trustee, for any of the following
purposes:

     (1) to evidence the succession of another Person to the Company, and the assumption by any
such successor of the covenants of the Company contained herein and in the Securities; or

     (2) to add to the covenants of the Company for the benefit of the Holders of all or any series
of Securities (as shall be specified in such supplemental indenture or indentures) or to surrender
any right or power herein conferred upon the Company; provided, that in respect of any such
additional covenant, such supplemental indenture may provide for a particular period of grace after
default (which period may be shorter or longer than that allowed in the case of other defaults) or
may provide for an immediate enforcement upon such a default or may limit the remedies available to
the Trustee upon an Event of Default or may limit the right of the Holders of a majority in
aggregate principal amount of the Securities of such series to waive such an Event of Default; or

59

 

     (3) to establish the form or terms of Securities of any series as permitted by Section 201 and
Section 301; or

     (4) to evidence and provide for the acceptance of appointment hereunder by a successor Trustee
with respect to the Securities of one or more series and to add to or change any of the provisions
of this Indenture as shall be necessary to provide for or facilitate the administration of the
trusts hereunder by more than one Trustee, pursuant to the requirements of Section 610; or

     (5) to cure any ambiguity, to correct or supplement any provision herein which may be
defective or inconsistent with any other provision herein, or to make any other provisions with
respect to matters or questions arising under this Indenture; provided that no action pursuant to
this clause (5) shall adversely affect the interests of the Holders of Securities of any series
then Outstanding in any material respect; or

     (6) to add to, delete from or revise the conditions, limitations and restrictions on the
authorized amount, terms or purposes of issue, authentication and delivery of Securities, as herein
set forth; or

     (7) to add any additional Events of Default with respect to all or any series of Securities
(as shall be specified in such supplemental indenture); or

     (8) to supplement any of the provisions of this Indenture to such extent as shall be necessary
for the defeasance and discharge of any series of Securities pursuant to Article Four, provided
that any such action shall not adversely affect the interests of any Holder of an Outstanding
Security of such series or any other Security in any material respect; or

     (9) to make provisions with respect to conversion or exchange rights of Holders of Securities
of any series; or

     (10) to add guarantees in respect of the Securities of one or more series and to provide for
the terms and conditions of release thereof; or

     (11) to convey, transfer, assign, mortgage or pledge to the Trustee as security for the
Securities of one or more series any property or assets and to provide for the terms and conditions
of release thereof; or

     (12) to change or eliminate any of the provisions of this Indenture, provided that any such
change or elimination shall become effective only when there is no Outstanding Security of any
series created prior to the execution of such supplemental indenture which is entitled to the
benefit of such provision; or

     (13) to provide for Definitive Securities in addition to or in place of Global Securities; or

     (14) to qualify the Indenture under the Trust Indenture Act; or

     (15) with respect to the Securities of a series, to conform the text of the Indenture or the
Securities of such series to any provision of the description thereof in the Company’s

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offering memorandum or prospectus relating to the initial offering of such Securities, to the
extent that such provision, in the good faith judgment of the Company, was intended to be a
verbatim recitation of a provision of the Indenture or such Securities, or

     (16) to make any other change that does not adversely affect the rights of Holders of
Outstanding Securities in any material respect.

     The Trustee is hereby required to join with the Company and any guarantors in the execution of
any such supplemental indenture, to make any further appropriate agreements and stipulations which
may be therein contained and to accept the conveyance, transfer, assignment, mortgage or pledge of
any property thereunder, but the Trustee shall not be obligated to enter into any such supplemental
indenture which affects the Trustee’s own rights, duties or immunities under this Indenture or
otherwise.

Section 902 Supplemental Indentures With Consent of Holders.

     With the consent of the Holders of not less than a majority (or such greater amount as is
provided for a particular series of Securities) in principal amount of the Outstanding Securities
of each series affected by such supplemental indenture (including consents obtained in connection
with a purchase of, or tender offer or exchange offer for, Securities of such series), by Act of
said Holders delivered to the Company and the Trustee, the Company (when authorized by or pursuant
to a Board Resolution) and the Trustee may enter into an indenture or indentures supplemental
hereto for the purpose of adding any provisions to or changing in any manner or eliminating any of
the provisions of this Indenture or of modifying in any manner the rights of the Holders of
Securities of such series under this Indenture or of the Securities of such series; provided,
however, that no such supplemental indenture, without the consent of the Holder of each Outstanding
Security affected thereby, shall

     (1) change the Stated Maturity of the principal of, or any premium or installment of interest
on or any Additional Amounts with respect to, any Security, or reduce the principal amount thereof
or the rate (or modify the calculation of such rate in a manner that reduces such rate) of interest
thereon or any Additional Amounts with respect thereto, or any premium payable upon the redemption
thereof or otherwise, or change the obligation of the Company to pay Additional Amounts pursuant to
Section 1004, or reduce the amount of the principal of an Original Issue Discount Security that
would be due and payable upon a declaration of acceleration of the Maturity thereof pursuant to
Section 502 or the amount thereof provable in bankruptcy pursuant to Section 504, change the
redemption provisions or adversely affect the right of repayment at the option of any Holder as
contemplated by Article Thirteen, or change the Place of Payment for any Security or the Currency
in which the principal of, any premium or interest on, or any Additional Amounts with respect to
any Security is payable, or impair the right to institute suit for the enforcement of any such
payment on or after the Stated Maturity thereof (or, in the case of redemption, on or after the
Redemption Date or, in the case of repayment at the option of the Holder, on or after the date for
repayment); or

     (2) reduce the percentage in principal amount of the Outstanding Securities of any series the
consent of the Holders of which are required for any such supplemental indenture, or the consent of
whose Holders is required for any waiver (of compliance with certain provisions of

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this Indenture or certain defaults hereunder and their consequences) provided for in this
Indenture, or reduce the requirements of Section 1504 for quorum or voting; or

     (3) modify any of the provisions of this Section 902 or Section 513 or Section 1005, except to
increase any such percentage or to provide that certain other provisions of this Indenture cannot
be modified or waived without the consent of the Holder of each Outstanding Security affected
thereby; or

     (4) make any change that adversely affects the right to convert or exchange any Security into
or for Common Stock or other securities, cash or other property in accordance with the terms of
such Security.

     A supplemental indenture which changes or eliminates any covenant or other provision of this
Indenture which shall have been included expressly and solely for the benefit of one or more
particular series of Securities, or which modifies the rights of the Holders of Securities of such
series with respect to such covenant or other provision, shall be deemed not to affect the rights
under this Indenture of the Holders of Securities of any other series.

     It shall not be necessary for any Act of Holders of Securities under this Section 902 to
approve the particular form of any proposed supplemental indenture, but it shall be sufficient if
such Act shall approve the substance thereof.

     Upon the request of the Company, accompanied by a copy of a Board Resolution authorizing the
execution of any such supplemental indenture, and upon the filing with the Trustee of evidence of
the consent of Holders of Securities as aforesaid, the Trustee shall join with the Company and any
guarantors in the execution of such supplemental indenture unless such supplemental indenture
affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise, in which
case the Trustee may in its discretion, but shall not be obligated to, enter into such supplemental
indenture.

Section 903 Execution of Supplemental Indentures.

     As a condition to executing, or accepting the additional trusts created by, any supplemental
indenture permitted by this Article Nine or the modifications thereby of the trusts created by this
Indenture, the Trustee shall be entitled to receive, and shall be fully protected in relying upon,
an Officer’s Certificate and Opinion of Counsel stating that the execution of such supplemental
indenture is authorized or permitted by this Indenture. The Trustee may, but shall not be
obligated to, enter into any such supplemental indenture which affects the Trustee’s own rights,
duties or immunities under this Indenture or otherwise.

Section 904 Revocation of Consents.

     Notwithstanding clause (5) of Section 104, any Holder of a Security or future Holder of the
same Security may revoke a consent as to its Security or portion of a Security. Any revocation of
a consent by the Holder of a Security or any such future Holder shall be effective only if the
Trustee receives the notice of revocation before the date on which the Trustee receives an
Officer’s Certificate from the Company certifying that the requisite number of consents have been
received. If, however, a record date is fixed pursuant to Section 104, then notwithstanding

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the second preceding sentence, those Persons who were Holders at such record date (or their
duly designated proxies), and only those Persons, shall be entitled to revoke any consent
previously given, whether or not such Persons continue to be Holders after such record date.

Section 905 Effect of Supplemental Indentures.

     A supplemental indenture or waiver becomes effective upon the (a) receipt by the Company or
the Trustee of the requisite number of consents (if required), (b) satisfaction of any conditions
to effectiveness as set forth in this Indenture or any such supplemental indenture or waiver and
(c) with respect to a supplemental indenture, execution of such supplemental indenture by the
Company and the Trustee. After a supplemental indenture or waiver becomes effective, it shall bind
every Holder, unless it makes a change described in any of clauses (1) through (4) of Section 902,
in which case, the supplemental indenture or waiver shall bind a Holder of a Security who is
affected thereby only if it has consented to such supplemental indenture or waiver and every
subsequent Holder of a Security or portion of a Security that evidences the same debt as the
consenting Holder’s Security. Upon the effectiveness of any supplemental indenture under this
Article, this Indenture shall be modified in accordance therewith, and such supplemental indenture
shall form a part of this Indenture for all purposes; and, except as provided in the preceding
sentence, every Holder of Securities theretofore or thereafter authenticated and delivered
hereunder shall be bound thereby.

Section 906 Reference in Securities to Supplemental Indentures.

     Securities of any series authenticated and delivered after the execution of any supplemental
indenture pursuant to this Article Nine may, and shall if required by the Trustee, bear a notation
in form approved by the Trustee as to any matter provided for in such supplemental indenture. If
the Company shall so determine, new Securities of any series so modified as to conform, in the
opinion of the Trustee and the Company, to any such supplemental indenture may be prepared and
executed by the Company and authenticated and delivered by the Trustee in exchange for Outstanding
Securities of such series.

Section 907 Conformity with Trust Indenture Act.

     Every supplemental indenture executed pursuant to this Article Nine shall conform to the
requirements of the Trust Indenture Act as then in effect.

Section 908 Notice of Supplemental Indenture.

     Promptly after the execution by the Company and the Trustee of any supplemental indenture
pursuant to Section 902, the Company shall transmit to the Holders of Outstanding Securities of any
series affected thereby a notice setting forth the substance of such supplemental indenture;
provided, that any failure to provide, or any defect in any such notice, shall not impair the
validity of any such supplemental indenture.

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ARTICLE TEN

COVENANTS

Section 1001 Payment of Principal, any Premium, Interest and Additional Amounts.

     The Company covenants and agrees for the benefit of the Holders of the Securities of each
series that it will duly and punctually pay the principal of, any premium and interest on and any
Additional Amounts with respect to, the Securities of such series in accordance with the terms
thereof and this Indenture.

Section 1002 Maintenance of Office or Agency.

     The Company shall maintain in each Place of Payment for any series of Securities an Office or
Agency where Securities of such series may be presented or surrendered for payment, where
Securities of such series may be surrendered for registration of transfer or exchange, where
Securities of such series that are convertible or exchangeable may be surrendered for conversion or
exchange, and where notices and demands to or upon the Company in respect of the Securities of such
series relating thereto and this Indenture may be served. The Company will give prompt written
notice to the Trustee of the location, and any change in the location, of such Office or Agency.
If at any time the Company shall fail to maintain any such required Office or Agency or shall fail
to furnish the Trustee with the address thereof, such presentations, surrenders, notices and
demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby
appoints the Trustee as its agent to receive all such presentations, surrenders, notices and
demands.

     The Company may also from time to time designate one or more other Offices or Agencies where
the Securities of one or more series may be presented or surrendered for any or all such purposes
and may from time to time rescind such designations; provided, however, that no such designation or
rescission shall in any manner relieve the Company of its obligation to maintain an Office or
Agency in each Place of Payment for Securities of any series for such purposes. The Company shall
give prompt written notice to the Trustee of any such designation or rescission and of any change
in the location of any such other Office or Agency.

     Unless otherwise provided in or pursuant to this Indenture, the Company hereby designates as
the Place of Payment for each series of Securities the Borough of Manhattan, The City of New York,
and initially appoints the Corporate Trust Office of The Bank of New York Mellon Trust Company,
N.A., acting through the corporate trust office of its affiliate, The Bank of New York Mellon,
located at 101 Barclay Street, New York, New York 10286, as the Office or Agency of the Company in
the Borough of Manhattan, The City of New York for such purpose. The Company may subsequently
appoint a different Office or Agency in the Borough of Manhattan, The City of New York for the
Securities of any series.

Section 1003 Money for Securities Payments to Be Held in Trust.

     If the Company shall at any time act as its own Paying Agent with respect to any series of
Securities, it shall, on or before each due date of the principal of, any premium or interest on or

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Additional Amounts with respect to any of the Securities of such series, segregate and hold in
trust for the benefit of the Persons entitled thereto a sum in the currency or currencies, currency
unit or units or composite currency or currencies in which the Securities of such series are
payable (except as otherwise specified pursuant to Section 301 for the Securities of such series)
sufficient to pay the principal or any premium, interest or Additional Amounts so becoming due
until such sums shall be paid to such Persons or otherwise disposed of as herein provided, and
shall promptly notify the Trustee of its failure so to act.

     Whenever the Company shall have one or more Paying Agents for any series of Securities, it
shall, on or prior to each due date of the principal of, any premium or interest on or any
Additional Amounts with respect to any Securities of such series, deposit with any Paying Agent a
sum (in the currency or currencies, currency unit or units or composite currency or currencies
described in the preceding paragraph) sufficient to pay the principal or any premium, interest or
Additional Amounts so becoming due, such sum to be held in trust for the benefit of the Persons
entitled thereto, and (unless such Paying Agent is the Trustee) the Company will promptly notify
the Trustee of its failure so to act.

     The Company shall cause each Paying Agent for any series of Securities (other than the
Trustee) to execute and deliver to the Trustee an instrument in which such Paying Agent shall agree
with the Trustee, subject to the provisions of this Section 1003, that such Paying Agent shall:

     (1) hold all sums held by it for the payment of the principal of, any premium or interest on
or any Additional Amounts with respect to Securities of such series in trust for the benefit of the
Persons entitled thereto until such sums shall be paid to such Persons or otherwise disposed of as
provided in or pursuant to this Indenture;

     (2) give the Trustee notice of any default by the Company (or any other obligor upon the
Securities of such series) in the making of any payment of principal, any premium or interest on or
any Additional Amounts with respect to the Securities of such series; and

     (3) at any time during the continuance of any such default, upon the written request of the
Trustee, forthwith pay to the Trustee all sums so held in trust by such Paying Agent.

     The Company may at any time, for the purpose of obtaining the satisfaction and discharge of
this Indenture or for any other purpose, pay, or by Company Order direct any Paying Agent to pay,
to the Trustee all sums held in trust by the Company or such Paying Agent, such sums to be held by
the Trustee upon the same terms as those upon which such sums were held by the Company or such
Paying Agent; and, upon such payment by any Paying Agent to the Trustee, such Paying Agent shall be
released from all further liability with respect to such sums.

     Except as otherwise provided herein or pursuant hereto, any money deposited with the Trustee
or any Paying Agent, or then held by the Company, in trust for the payment of the principal of, any
premium or interest on or any Additional Amounts with respect to any Security of any series and
remaining unclaimed for two years after such principal or any such premium or interest or any such
Additional Amounts shall have become due and payable shall be paid to the Company on Company
Request, or (if then held by the Company) shall be discharged from such

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trust; and the Holder of such Security shall thereafter, as an unsecured general creditor,
look only to the Company for payment thereof, and all liability of the Trustee or such Paying Agent
with respect to such trust money, and all liability of the Company as trustee thereof, shall
thereupon cease; provided, however, that the Trustee or such Paying Agent, before being required to
make any such repayment, may at the expense of the Company either cause to be published once, in an
Authorized Newspaper in each Place of Payment for such series, or may cause to be mailed once to
Holders of Registered Securities of such series, notice that such money remains unclaimed and that,
after a date specified therein, which shall not be less than 30 days from the date of such
publication or mailing nor later than two years after such principal and any premium or interest or
Additional Amounts shall have become due and payable, any unclaimed balance of such money then
remaining will be repaid to the Company.

Section 1004 Additional Amounts.

     If any Securities of a series provide for the payment of Additional Amounts, the Company
agrees to pay to the Holder of any such Security Additional Amounts as provided in or pursuant to
this Indenture or such Securities. Whenever in this Indenture there is mentioned, in any context,
the payment of the principal of or any premium or interest on, or in respect of, any Security of
any series, such mention shall be deemed to include mention of the payment of Additional Amounts
provided by the terms of such series established hereby or pursuant hereto to the extent that, in
such context, Additional Amounts are, were or would be payable in respect thereof pursuant to such
terms, and express mention of the payment of Additional Amounts (if applicable) in any provision
hereof shall not be construed as excluding Additional Amounts in those provisions hereof where such
express mention is not made.

     Except as otherwise provided in or pursuant to this Indenture or the Securities of the
applicable series, if the Securities of a series provide for the payment of Additional Amounts, at
least 10 days prior to the first Interest Payment Date with respect to such series of Securities
(or if the Securities of such series shall not bear interest prior to Maturity, the first day on
which a payment of principal is made), and at least 10 days prior to each date of payment of
principal or interest if there has been any change with respect to the matters set forth in the
below-mentioned Officer’s Certificate, the Company shall furnish to the Trustee and the principal
Paying Agent or Paying Agents, if other than the Trustee, an Officer’s Certificate instructing the
Trustee and such Paying Agent or Paying Agents whether such payment of principal of and premium, if
any, or interest on the Securities of such series shall be made to Holders of Securities of such
series who are United States Aliens (as demonstrated by delivery of appropriate tax forms) without
withholding for or on account of any tax, assessment or other governmental charge described in the
Securities of such series. If any such withholding shall be required, then such Officer’s
Certificate shall specify by country the amount, if any, required to be withheld on such payments
to such Holders of Securities, and the Company agrees to pay to the Trustee or such Paying Agent
the Additional Amounts required by the terms of such Securities. The Company covenants to
indemnify the Trustee and any Paying Agent for, and to hold them harmless against, any loss,
liability or expense reasonably incurred without negligence or bad faith on their part arising out
of or in connection with actions taken or omitted by any of them in reliance on any Officer’s
Certificate furnished pursuant to this Section 1004.

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Section 1005 Waiver of Certain Covenants.

     The Company may omit in any particular instance to comply with any term, provision or
condition specified pursuant to Section 301 with respect to the Securities of any series if the
Company shall have obtained or filed with the Trustee, prior to the time of such failure or
omission, evidence (as described in Section 104) of the consent of the Holders of a majority in
aggregate principal amount of the Outstanding Securities of such series, by Act of such Holders,
either waiving such compliance in such instance or generally waiving compliance with such term,
provision or condition, but no such waiver shall extend to or affect such term, provision or
condition except to the extent so expressly waived, and, until such waiver shall become effective
in accordance with Section 905, the obligations of the Company and the duties of the Trustee in
respect of any such term, provision or condition shall remain in full force and effect.

Section 1006 Company Statement as to Compliance.

     (1) If any Securities are Outstanding under this Indenture, the Company shall deliver to the
Trustee, within 120 days after the end of each fiscal year, a written statement (which need not be
contained in or accompanied by an Officer’s Certificate) signed by the principal executive officer,
the principal financial officer or the principal accounting officer, stating that

     (a) in the course of the performance of his or her duties as an officer of the Company
he or she would normally have knowledge of any default by the Company in the performance of
the covenants contained in this Indenture, and

     (b) to his or her knowledge, the Company has complied with all the conditions and
covenants imposed on it under this Indenture throughout such year, or, if there has been a
noncompliance in the fulfillment of any such condition or covenant, specifying each such
noncompliance known to him or her and the nature and status thereof.

     (2) The Trustee shall have no duty to monitor the Company’s compliance with the covenants
contained in this Indenture other than to receive written notices described in Section 1006(1).

ARTICLE ELEVEN

REDEMPTION OF SECURITIES

Section 1101 Applicability of Article.

     Redemption of Securities of any series at the option of the Company as permitted or required
by the terms of such Securities shall be made in accordance with the terms of such Securities and
(except as otherwise provided herein or pursuant hereto) this Article Eleven.

Section 1102 Election to Redeem; Notice to Trustee.

     The election of the Company to optionally redeem any Securities shall be evidenced by or
pursuant to a Board Resolution. In case of any redemption at the election of the Company of the
Securities of any series, the Company shall, at least 60 days prior to the Redemption Date

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fixed by the Company (unless a shorter notice shall be satisfactory to the Trustee), notify
the Trustee of such Redemption Date and of the principal amount of Securities of such series to be
redeemed. In the case of any redemption of Securities (a) prior to the expiration of any
restriction on such redemption provided in the terms of such Securities or elsewhere in this
Indenture, or (b) pursuant to an election of the Company which is subject to a condition specified
in the terms of such Securities or elsewhere in this Indenture, the Company shall furnish the
Trustee with an Officer’s Certificate evidencing compliance with such restriction or condition.

Section 1103 Selection by Trustee of Securities to be Redeemed.

     If less than all of the Securities of any series with the same issue date, interest rate or
formula, Stated Maturity and other terms are to be redeemed, the particular Securities to be
redeemed shall be selected not more than 60 days prior to the Redemption Date by the Trustee from
the Outstanding Securities of such series not previously called for redemption on a pro rata basis
or by lot (whichever is consistent with the Trustee’s customary practice); provided, however, that
no such partial redemption shall reduce the portion of the principal amount of a Registered
Security of such series not redeemed to less than the minimum denomination for a Security of such
series established herein or pursuant hereto.

     The Trustee shall promptly notify the Company and the Security Registrar (if other than
itself) in writing of the Securities selected for redemption and, in the case of any Securities
selected for partial redemption, the principal amount thereof to be redeemed.

     For all purposes of this Indenture, unless the context otherwise requires, all provisions
relating to the redemption of Securities shall relate, in the case of any Securities redeemed or to
be redeemed only in part, to the portion of the principal of such Securities which has been or is
to be redeemed.

     Unless otherwise specified in or pursuant to this Indenture or the Securities of any series,
if any Security selected for partial redemption is converted into or exchanged for Common Stock or
other securities, cash or other property in part before termination of the conversion or exchange
right with respect to the portion of the Security so selected, the converted portion of such
Security shall be deemed (so far as may be) to be the portion selected for redemption. Securities
which have been converted or exchanged during a selection of Securities to be redeemed shall be
treated by the Trustee as Outstanding for the purpose of such selection.

Section 1104 Notice of Redemption.

     Notice of redemption shall be given in the manner provided in Section 106, not less than 30
nor more than 60 days prior to the Redemption Date, unless a shorter period is specified in the
Securities to be redeemed, to the Holders of Securities to be redeemed. Failure to give notice by
mailing in the manner herein provided to the Holder of any Registered Securities designated for
redemption as a whole or in part, or any defect in the notice to any such Holder, shall not affect
the validity of the proceedings for the redemption of any other Securities or portion thereof.

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     Any notice that is mailed to the Holder of any Registered Securities in the manner herein
provided shall be conclusively presumed to have been duly given, whether or not such Holder
receives the notice.

     All notices of redemption shall state:

     (1) the Redemption Date,

     (2) the Redemption Price or if not then ascertainable, the manner of calculation thereof,

     (3) if less than all Outstanding Securities of any series are to be redeemed, the
identification (and, in the case of partial redemption, the principal amount) of the particular
Security or Securities to be redeemed,

     (4) in case any Security is to be redeemed in part only, the notice which relates to such
Security shall state that on and after the Redemption Date, upon surrender of such Security, the
Holder of such Security will receive, without charge, a new Security or Securities of authorized
denominations for the principal amount thereof remaining unredeemed,

     (5) that, on the Redemption Date, the Redemption Price shall become due and payable upon each
such Security or portion thereof to be redeemed, and, if applicable, that interest thereon shall
cease to accrue on and after said date, subject to such conditions as may be specified pursuant to
Section 301 with respect to such Security,

     (6) the place or places where such Securities are to be surrendered for payment of the
Redemption Price and any accrued interest and Additional Amounts pertaining thereto,

     (7) that the redemption is for a sinking fund, if such is the case,

     (8) in the case of Securities of any series that are convertible or exchangeable into Common
Stock or other securities, cash or other property, the conversion or exchange price or rate, the
date or dates on which the right to convert or exchange the principal of the Securities of such
series to be redeemed will commence or terminate and the place or places where such Securities may
be surrendered for conversion or exchange, and

     (9) the CUSIP number (or any other numbers used by a Depositary to identify such Securities).

     A notice of redemption published as contemplated by Section 106 need not identify particular
Registered Securities to be redeemed.

     Notice of redemption of Securities to be redeemed at the election of the Company shall be
given by the Company or, upon Company Request, by the Trustee in the name and at the expense of the
Company.

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Section 1105 Deposit of Redemption Price.

     At or prior to 10:00 a.m., New York City time, on any Redemption Date, the Company shall
deposit, with respect to the Securities of any series called for redemption pursuant to Section
1104, with the Trustee or with a Paying Agent (or, if the Company is acting as its own Paying
Agent, segregate and hold in trust as provided in Section 1003) an amount of money in the
applicable Currency sufficient to pay the Redemption Price of, and (except if the Redemption Date
shall be an Interest Payment Date, unless otherwise specified pursuant to Section 301 or in the
Securities of such series) any accrued interest on and Additional Amounts with respect to such
accrued interest, all such Securities or portions thereof which are to be redeemed on that date.

Section 1106 Securities Payable on Redemption Date.

     Notice of redemption having been given as aforesaid and all conditions specified pursuant to
Section 301 having been satisfied, the Securities so to be redeemed shall, on the Redemption Date,
become due and payable at the Redemption Price therein specified, and from and after such date
(unless the Company shall default in the payment of the Redemption Price and accrued interest) such
Securities shall cease to bear interest. Upon surrender of any such Security for redemption in
accordance with said notice, such Security shall be paid by the Company at the Redemption Price,
together with any accrued interest and Additional Amounts to the Redemption Date; provided,
however, that, except as otherwise specified in or pursuant to this Indenture or the Registered
Securities of such series, installments of interest on Registered Securities whose Stated Maturity
is on or prior to the Redemption Date shall be payable to the Holders of such Securities, or one or
more Predecessor Securities, registered as such at the close of business on the Regular Record
Dates therefor according to their terms and the provisions of Section 307.

     Unless otherwise specified in or pursuant to this Indenture or the Securities of any series,
if any Security called for redemption shall not be so paid upon surrender thereof for redemption,
the principal and any premium, until paid, shall bear interest from the Redemption Date at the rate
prescribed therefor in the Security.

Section 1107 Securities Redeemed in Part.

     Any Registered Security which is to be redeemed only in part shall be surrendered at any
Office or Agency for such Security (with, if the Company or the Trustee so requires, due
endorsement by, or a written instrument of transfer in form satisfactory to the Company and the
Trustee duly executed by, the Holder thereof or his attorney duly authorized in writing) and the
Company shall execute and the Trustee shall authenticate and deliver to the Holder of such Security
without service charge, a new Registered Security or Securities of the same series, containing
identical terms and provisions, of any authorized denomination as requested by such Holder in
aggregate principal amount equal to and in exchange for the unredeemed portion of the principal
amount of the Security so surrendered. If a Global Security is so surrendered, the Company shall
execute, and the Trustee shall authenticate and deliver to or on behalf of the U.S. Depositary or
other Depositary for such Global Security as shall be specified in the Company Order with respect
thereto to the Trustee, without service charge, a new Global Security in a

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denomination equal to and in exchange for the unredeemed portion of the principal of the
Global Security so surrendered.

Section 1108 Repurchases on the Open Market.

     The Company or any Affiliate of the Company may at any time or from time to time repurchase
any of the Securities in the open market or otherwise. Such Securities may, at the option of the
Company or the relevant Affiliate of the Company, be held, resold or surrendered to the Trustee for
cancellation.

ARTICLE TWELVE

SINKING FUNDS

Section 1201 Applicability of Article.

     The provisions of this Article Twelve shall be applicable to any sinking fund for the
retirement of Securities of a series, except as otherwise permitted or required in or pursuant to
this Indenture or any Security of such series issued pursuant to this Indenture.

     The minimum amount of any sinking fund payment provided for by the terms of Securities of any
series is herein referred to as a “mandatory sinking fund payment,” and any payment in excess of
such minimum amount provided for by the terms of Securities of such series is herein referred to as
an “optional sinking fund payment.” If provided for by the terms of Securities of any series, the
cash amount of any sinking fund payment may be subject to reduction as provided in Section 1202.
Each sinking fund payment shall be applied to the redemption of Securities of any series as
provided for by the terms of Securities of such series and this Indenture.

Section 1202 Satisfaction of Sinking Fund Payments with Securities.

     The Company may, in satisfaction of all or any part of any sinking fund payment with respect
to the Securities of any series to be made pursuant to the terms of such Securities (1) deliver
Outstanding Securities of such series (other than any of such Securities previously called for
redemption or any of such Securities in respect of which cash shall have been released to the
Company) and (2) apply as a credit Securities of such series which have been redeemed either at the
election of the Company pursuant to the terms of such series of Securities or through the
application of permitted optional sinking fund payments pursuant to the terms of such Securities,
provided that such Securities have not been previously so credited. Such Securities shall be
received and credited for such purpose by the Trustee at the Redemption Price specified in such
Securities for redemption through operation of the sinking fund and the amount of such sinking fund
payment shall be reduced accordingly. If as a result of the delivery or credit of Securities of
any series in lieu of cash payments pursuant to this Section 1202, the principal amount of
Securities of such series to be redeemed in order to satisfy the remaining sinking fund payment
shall be less than $100,000, the Trustee need not call Securities of such series for redemption,
except upon Company Request, and such cash payment shall be held by the Trustee or a Paying Agent
and applied to the next succeeding sinking fund payment, provided, however, that the

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Trustee or such Paying Agent shall at the request of the Company from time to time pay over
and deliver to the Company any cash payment so being held by the Trustee or such Paying Agent upon
delivery by the Company to the Trustee of Securities of that series purchased by the Company having
an unpaid principal amount equal to the cash payment requested to be released to the Company.

Section 1203 Redemption of Securities for Sinking Fund.

     Not less than 60 days prior to each sinking fund payment date for any series of Securities,
the Company shall deliver to the Trustee an Officer’s Certificate specifying the amount of the next
ensuing mandatory sinking fund payment for that series pursuant to the terms of that series, the
portion thereof, if any, which is to be satisfied by payment of cash and the portion thereof, if
any, which is to be satisfied by delivering and crediting of Securities of that series pursuant to
Section 1202, and the basis for such credit and the optional amount, if any, to be added in cash to
the next ensuing mandatory sinking fund payment, and will also deliver to the Trustee any
Securities to be so credited and not theretofore delivered. If such Officer’s Certificate shall
specify an optional amount to be added in cash to the next ensuing mandatory sinking fund payment,
the Company shall thereupon be obligated to pay the amount therein specified. Not less than 60
days before each such sinking fund payment date the Trustee shall select the Securities to be
redeemed upon such sinking fund payment date in the manner specified in Section 1103 and cause
notice of the redemption thereof to be given in the name of and at the expense of the Company in
the manner provided in Section 1104. Such notice having been duly given, the redemption of such
Securities shall be made upon the terms and in the manner stated in Section 1106 and Section 1107.

ARTICLE THIRTEEN

REPAYMENT AT THE OPTION OF HOLDERS

Section 1301 Applicability of Article.

     Securities of any series which are repayable at the option of the Holders thereof before their
Stated Maturity shall be repaid in accordance with the terms of the Securities of such series. The
repayment of any principal amount of Securities pursuant to such option of the Holder to require
repayment of Securities before their Stated Maturity, for purposes of Section 309, shall not
operate as a payment, redemption or satisfaction of the indebtedness represented by such Securities
unless and until the Company, at its option, shall deliver or surrender the same to the Trustee
with a directive that such Securities be cancelled. Notwithstanding anything to the contrary
contained in this Section 1301, in connection with any repayment of Securities, the Company may
arrange for the purchase of any Securities by an agreement with one or more investment bankers or
other purchasers to purchase such Securities by paying to the Holders of such Securities on or
before the close of business on the repayment date an amount not less than the repayment price
payable by the Company on repayment of such Securities, and the obligation of the Company to pay
the repayment price of such Securities shall be satisfied and discharged to the extent such payment
is so paid by such purchasers.

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ARTICLE FOURTEEN

SECURITIES IN FOREIGN CURRENCIES

Section 1401 Applicability of Article.

     Whenever this Indenture provides for (i) any action by, or the determination of any of the
rights of, Holders of Securities of any series in which not all of such Securities are denominated
in the same Currency, or (ii) any distribution to Holders of Securities, in the absence of any
provision to the contrary pursuant to this Indenture or the Securities of any particular series,
any amount in respect of any Security denominated in a Foreign Currency shall be treated for any
such action or distribution as that amount of Dollars that could be obtained for such amount on
such reasonable basis of exchange and as of the record date with respect to Registered Securities
of such series (if any) for such action, determination of rights or distribution (or, if there
shall be no applicable record date, such other date reasonably proximate to the date of such
action, determination of rights or distribution) as the Company may specify in a written notice to
the Trustee or, in the absence of such written notice, as the Trustee may determine.

ARTICLE FIFTEEN

MEETINGS OF HOLDERS OF SECURITIES

Section 1501 Purposes for Which Meetings May Be Called.

     A meeting of Holders of Securities of any series may be called at any time and from time to
time pursuant to this Article Fifteen to make, give or take any request, demand, authorization,
direction, notice, consent, waiver or other Act provided by this Indenture to be made, given or
taken by Holders of Securities of such series.

Section 1502 Call, Notice and Place of Meetings.

     (1) The Trustee may at any time call a meeting of Holders of Securities of any series for any
purpose specified in Section 1501, to be held at such time and at such place in the Borough of
Manhattan, The City of New York as the Trustee may select and as shall be acceptable to the
Company. Notice of every meeting of Holders of Securities of any series, setting forth the time
and the place of such meeting and in general terms the action proposed to be taken at such meeting,
shall be given, in the manner provided in Section 106, not less than 21 nor more than 180 days
prior to the date fixed for the meeting.

     (2) In case at any time the Company (by or pursuant to a Board Resolution) or the Holders of
at least 10% in principal amount of the Outstanding Securities of any series shall have requested
the Trustee to call a meeting of the Holders of Securities of such series for any purpose specified
in Section 1501, by written request setting forth in reasonable detail the action proposed to be
taken at the meeting, and the Trustee shall not have mailed notice of such meeting within 21 days
after receipt of such request or shall not thereafter proceed to cause the meeting to be held as
provided herein, then the Company or the Holders of Securities of such series in the amount above
specified, as the case may be, may determine the time and the place in the

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Borough of Manhattan, The City of New York for such meeting and may call such meeting for such
purposes by giving notice thereof as provided in clause (1) of this Section 1504.

Section 1503 Persons Entitled to Vote at Meetings.

     To be entitled to vote at any meeting of Holders of Securities of any series, a Person shall
be (1) a Holder of one or more Outstanding Securities of such series, or (2) a Person appointed by
an instrument in writing as proxy for a Holder or Holders of one or more Outstanding Securities of
such series by such Holder or Holders. The only Persons who shall be entitled to be present or to
speak at any meeting of Holders of Securities of any series shall be the Persons entitled to vote
at such meeting and their counsel, any representatives of the Trustee and its counsel and any
representatives of the Company and its counsel.

Section 1504 Quorum; Action.

     The Persons entitled to vote a majority in principal amount of the Outstanding Securities of a
series shall constitute a quorum for a meeting of Holders of Securities of such series; provided,
however, that if any action is to be taken at such meeting with respect to a consent or waiver
which this Indenture expressly provides may be given by the Holders of a different percentage in
principal amount of the Outstanding Securities of a series, the Persons entitled to vote such
percentage in principal amount of the Outstanding Securities of such series shall constitute a
quorum. In the absence of a quorum within 30 minutes after the time appointed for any such
meeting, the meeting shall, if convened at the request of Holders of Securities of such series, be
dissolved. In any other case the meeting may be adjourned for a period of not less than 10 days as
determined by the chairman of the meeting prior to the adjournment of such meeting. In the absence
of a quorum at any such adjourned meeting, such adjourned meeting may be further adjourned for a
period of not less than 10 days as determined by the chairman of the meeting prior to the
adjournment of such adjourned meeting. Notice of the reconvening of any adjourned meeting shall be
given as provided in Section 1502(1), except that such notice need be given only once not less than
five days prior to the date on which the meeting is scheduled to be reconvened. Notice of the
reconvening of an adjourned meeting shall state expressly the percentage, as provided above, of the
principal amount of the Outstanding Securities of such series which shall constitute a quorum.

     Except as limited by the proviso to Section 902, any resolution presented to a meeting or
adjourned meeting duly reconvened at which a quorum is present as aforesaid may be adopted only by
the affirmative vote of the Holders of a majority in principal amount of the Outstanding Securities
of that series; provided, however, that, except as limited by the proviso to Section 902, any
resolution with respect to any consent or waiver which this Indenture or any supplemental indenture
expressly provides may be given by the Holders of at least 66-2/3% in principal amount of the
Outstanding Securities of a series may be adopted at a meeting or an adjourned meeting duly
convened and at which a quorum is present as aforesaid only by the affirmative vote of the Holders
of 66-2/3% in principal amount of the Outstanding Securities of that series; and provided, further,
that, except as limited by the proviso to Section 902, any resolution with respect to any request,
demand, authorization, direction, notice, consent, waiver or other Act which this Indenture or any
supplemental indenture expressly provides may be made, given or taken by the Holders of a different
specified percentage, which is less than a majority, in

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principal amount of the Outstanding Securities of a series, may be adopted at a meeting or an
adjourned meeting duly reconvened and at which a quorum is present as aforesaid by the affirmative
vote of the Holders of such specified percentage in principal amount of the Outstanding Securities
of such series.

     Any resolution passed or decision taken at any meeting of Holders of Securities of any series
duly held in accordance with this Section 1504 shall be binding on all the Holders of Securities of
such series, whether or not such Holders were present or represented at the meeting.

Section 1505 Determination of Voting Rights; Conduct and Adjournment of Meetings.

     (1) Notwithstanding any other provisions of this Indenture, the Trustee may make such
reasonable regulations as it may deem advisable for any meeting of Holders of Securities of such
series in regard to proof of the holding of Securities of such series and of the appointment of
proxies and in regard to the appointment and duties of inspectors of votes, the submission and
examination of proxies, certificates and other evidence of the right to vote, and such other
matters concerning the conduct of the meeting as it shall deem appropriate. Except as otherwise
permitted or required by any such regulations, the holding of Securities shall be proved in the
manner specified in Section 104 and the appointment of any proxy shall be proved in the manner
specified in Section 104. Such regulations may provide that written instruments appointing
proxies, regular on their face, may be presumed valid and genuine without the proof specified in
Section 104 or other proof.

     (2) The Trustee shall, by an instrument in writing, appoint a temporary chairman of the
meeting, unless the meeting shall have been called by the Company or by Holders of Securities as
provided in Section 1502(2), in which case the Company or the Holders of Securities of the series
calling the meeting, as the case may be, shall in like manner appoint a temporary chairman. A
permanent chairman and a permanent secretary of the meeting shall be elected by vote of the Persons
entitled to vote a majority in principal amount of the Outstanding Securities of such series
represented at the meeting.

     (3) At any meeting, each Holder of a Security of such series or proxy shall be entitled to one
vote for each $1,000 principal amount of Securities of such series held or represented by him;
provided, however, that no vote shall be cast or counted at any meeting in respect of any Security
challenged as not Outstanding and ruled by the chairman of the meeting to be not Outstanding. The
chairman of the meeting shall have no right to vote, except as a Holder of a Security of such
series or proxy.

     (4) Any meeting of Holders of Securities of any series duly called pursuant to Section 1502 at
which a quorum is present may be adjourned from time to time by Persons entitled to vote a majority
in principal amount of the Outstanding Securities of such series represented at the meeting; and
the meeting may be held as so adjourned without further notice.

Section 1506 Counting Votes and Recording Action of Meetings.

     The vote upon any resolution submitted to any meeting of Holders of Securities of any series
shall be by written ballots on which shall be subscribed the signatures of the Holders of

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Securities of such series or of their representatives by proxy and the principal amounts and
serial numbers of the Outstanding Securities of such series held or represented by them. The
permanent chairman of the meeting shall appoint two inspectors of votes who shall count all votes
cast at the meeting for or against any resolution and who shall make and file with the permanent
secretary of the meeting their verified written reports in triplicate of all votes cast at the
meeting. A record, at least in triplicate, of the proceedings of each meeting of Holders of
Securities of any series shall be prepared by the permanent secretary of the meeting and there
shall be attached to said record the original reports of the inspectors of votes on any vote by
ballot taken thereat and affidavits by one or more Persons having knowledge of the facts setting
forth a copy of the notice of the meeting and showing that said notice was given as provided in
Section 1502 and, if applicable, Section 1504. Each copy shall be signed and verified by the
affidavits of the permanent chairman and secretary of the meeting and one such copy shall be
delivered to the Company, and another to the Trustee to be preserved by the Trustee, the latter to
have attached thereto the ballots voted at the meeting. Any record so signed and verified shall be
conclusive evidence of the matters therein stated.

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     IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of
the day and year first above written.

	 	 	 	 	 
	 	THE WILLIAMS COMPANIES, INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 
	 	THE BANK OF NEW YORK MELLON TRUST
COMPANY,
N.A., as Trustee
 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

Base Indenture

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00159-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00159-of-00352.parquet"}]]