Document:

exv10w20

 

Exhibit 10.20

Dynavax Technologies Corporation

The following is summary of a Lease Agreement (“Lease Agreement”) for 9 and 11 Eichsfelder Strasse,
Düsseldorf dates as of August 14, 1990, as amended. The Lease Agreement is in German and this
summary in English is provided pursuant to Rule 12b-12(d)(3).

Effective Date: Lease for 9 and 11 Eichsfelder Strasse, Düsseldorf – Dated 8/14/1990 (the building
was not completed until 1994 when the lease term began)

	 	 	 
	 

	 	Amendment No. 1 – Undated
	 

	 	Amendment No. 2 – Dated 03/24/1997
	 

	 	Amendment No. 3 – Dated 07/03/1999
	 

	 	Amendment No. 4 – Dated 10/11/2002
	 

	 	Amendment No. 5 – Dated 07/02/2003
	 

	 	Amendment No. 6 – Dated 5/17/2004
	 
	 	 
	Landlord:

	 	The name of the landlord effective April 2006 is: HBI
Düsseldorf S.a.r.l. They are represented by Halverton Real Estate Investment
Management GmbH, Friedrichstraße 185-187, D-10117 Berlin.
	 
	 	 
	Term:

	 	The current term expires on August 31, 2009. The Lease
Agreement provides an option for the Company to extend the term an additional 5
years; provided that the option is exercised not later than 18 months from the
scheduled expiration date.

Leased Premises:

     Area
(m2=square meters):

Offices: 1.649 m2 (Eichsfelderstr. 11 – B1)

Offices: 159 m2 (Eichsfelderstr. 9 – B4)

Warehouse: 652 m2 (Eichsfelderstr. 11 – B2)

Warehouse: 544 m2 (Eichsfelderstr. 9 – B3)

Warehouse: 467 m2 (Eichsfelderstr. 9 – B4)

Parking space: 28

Underground parking: 11

(According to Addendum No. 6, dated 17.05.2004)

     Rent/month (EUR=Euros):

Office: 9.71 EUR/m2

Warehouse: Eichsfelderstr. 11–B2 — 4.09 EUR/m2

Eichsfelderstr. 9–B3 — 3.80 EUR/m2

Eichsfelderstr. 9–B4 – 4.09 EUR/m2

Parking space: 30.67 EUR, flat rate

Underground parking: 40.90 EUR. flat rate

Total: 25,508.25 EUR/month Plus VAT, plus ancillary expenses (prepayment of 6,630 EUR/month).

Payments are made monthly.

Annual increases in the foregoing apply based on the local consumer price increase index.

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Structural alterations are at the expense of the Company. At the end of the contract term, the
landlord has right to request that the leased premises be returned to their original condition.

A long term deposit of Euro 115,000 was required to be made and held as security for the lease.

Other Provisions:

The remaining provisions of the Lease Agreement contain requirements with respect to habitability
of the premises; provision of services by the landlord with respect to the leased premises; tenant
obligations with respect to occupancy; terms of payments; effect of breach.

40exv10w21

 

CONFIDENTIAL

[ * ] = Certain confidential information contained in this document, marked by brackets,
has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

Exhibit 10.21

DEFINITIVE COMMERCIAL AGREEMENT

This Definitive Commercial Agreement (the “Agreement”) is entered into this 21st day of April, 2006
by and between:

Rhein Biotech NV, incorporated under the laws of the Netherlands having its registered office at
Oude Maasstraat 47, NL 6229 BC Maastricht, The Netherlands (hereinafter “RBNV”);

And

Rhein Biotech GmbH, formed and in good standing under the laws of Germany, having its seat in
Dusseldorf, Eichsfelder Strasse 11, 40595, Germany, (“RBG”);

And

Dynavax Technologies Corporation, a USA corporation having its offices at 2929 Seventh Street,
Suite 100, Berkeley, CA 94710 USA (“Dynavax”).

(With each of RBNV, RBG and Dynavax, referred individually as a “Party” and collectively as the
“Parties”)

RECITALS

     Whereas, Crucell NV (“Parent”) is the owner of substantially all of the share capital
of Berna Biotech AG (“Berna”), which is the owner of substantially all of the share capital
of RBNV, which is in the vaccine business and owns 100 percent of the share capital of RBG;

     Whereas, Dynavax is in the vaccine development business and is a party to a License and Supply
Agreement with Berna;

     Whereas, Dynavax is purchasing RBG, and RBNV is selling RBG to Dynavax, under the Share Sale
and Purchase Agreement dated March 27, 2006;

     Whereas, RBNV and Dynavax have entered into a Letter of Intent dated March 10, 2006, in
connection with the purchase of the RBG stock and the commercial agreements associated therewith
(the “Letter of Intent”), for the purpose of reaching non-binding understanding as to certain terms
and binding understanding as to others (as set forth therein), in order to negotiate a written
share purchase agreement and written commercial agreements (jointly the “Definitive Agreements,”
more particularly defined below);

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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     And Whereas, RBNV and Dynavax have negotiated the Definitive Agreements, including the terms
of the Agreement, which provides, inter alia, for the termination of certain pre-existing
agreements among the Parties (including superseding such Letter of Intent with regard to the
subject matter of this Agreement), and the granting of certain license and other rights, as more
specifically described hereinbelow.

     NOW THEREFORE, in consideration of the foregoing premises and the mutual covenants set forth
below, the Parties agree as follows:

SECTION 1. DEFINITIONS. The following initially capitalized terms have the following meanings when
used in this Agreement (and derivative forms of them will be interpreted accordingly):

	 	1.1	 	“Affiliate” means, as to any person or entity, any other person or entity,
which controls, is controlled by, or is under common control with such person or
entity. A person or entity shall be regarded as in control of another entity only if
it owns or controls, directly or indirectly, at least fifty percent (50%) of the equity
securities or other ownership interests in the subject entity entitled to vote in the
election of directors or with the power to direct or elect management of such subject
entity. Affiliates of RBNV include Parent, Green Cross Vaccine Corp. (an entity
organized under the laws of the Republic of Korea), Rhein Vaccines B.V., Berna Biotech
A.G., and Crucell Holland B.V.,. Affiliation shall be determined based on RBG being
wholly owned by Dynavax, and not owned at all by RBNV.
	 
	 	1.2	 	“Alum” means any composition that is or contains aluminum in any form,
regardless of whether [ * ]
	 
	 	1.3	 	“Asian Country” means any country geographically located on the continent of
Asia. To be clear, the Asian Countries exclude Australia and New Zealand.
	 
	 	1.4	 	“Closing Date” means the first date set forth above.
	 
	 	1.5	 	“Control” means, with respect to a particular item of know-how or a particular
Patent at a given date, the ownership of or a license under, together with the right to
grant a license or sublicense of the scope set forth in the Agreement under, such item
of know-how or Patent, without breaching any written agreement with a third party in
existence as of such date.
	 
	 	1.6	 	“Cytovax” means the prophylactic cytomegalovirus vaccine currently under
development in NovoVacs BV.
	 
	 	1.7	 	“Cytovax Program Products” means [ * ] , including Cytovax.
	 
	 	1.8	 	“Definitive Agreements” means (i) the Share Sale and Purchase Agreement
(parties are RBNV and Dynavax) dated as of March 27, 2006; (ii) this Agreement (parties
are RBNV, RBG, and Dynavax); (iii) the Supervax Exclusive License Agreement dated as of
the Closing Date (parties are RBNV, RBG and Green

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	 	 	Cross); (iv) the Termination Agreement dated as of the Closing Date (parties are
Berna and Dynavax); and (v) the Waiver Agreement relating to the employee stock
plans (by managers and employees of RBG) dated as of the Closing Date.
	 
	 	1.9	 	[ * ]
	 
	 	1.10	 	“Dynavax Notice” has the meaning given in the first paragraph of Section 3.1.
	 
	 	1.11	 	“Existing Contracts” has the meaning given in Section 2.1.
	 
	 	1.12	 	“Heplisav” means Dynavax’s current Hepatitis B vaccine containing Hepatitis B
surface antigen and Dynavax’s 1018 ISS.
	 
	 	1.13	 	“Heplisav Program Product” means [ * ] In this context, [ * ] The product
Heplisav is included among the Heplisav Program Products.
	 
	 	1.14	 	[ * ]
	 
	 	1.15	 	“High Cost Registration European Countries” means all countries that are
members of the European Union as of the Closing Date, and Norway, Switzerland and
Iceland, other than the Low Cost Registration European Countries.
	 
	 	1.16	 	“Know How” means all materials, information, experience and data, formulae,
procedures, results and specifications, in written or electronic form, that (i) are
Controlled by RBG or RBNV as of the Closing Date, (ii) are not generally known and
(iii) are not subject to a third party confidentiality obligation that prevents RBG or
RBNV from disclosing the same. Know How includes the Master Cell Line.
	 
	 	1.17	 	“Low Cost Registration European Countries” means any country within the
European Union as of the Closing Date, and Norway, Switzerland and Iceland, in which
the approval for marketing of a vaccine product [ * ]
	 
	 	1.18	 	“Master Cell Line “ means the [ * ] strain, designated as [ * ] that exists
as master cell banks designated as [ * ] and working cell banks designated as [ * ]
as such cell line is described and referred to in the following IND filed with the FDA:
[ * ] This strain is referred to between the Parties as the [ * ] strain.
	 
	 	1.19	 	“Patents” means all granted patents, including utility models and certificates
of invention, and reissues, reexaminations, supplementary protection certificates,
extensions, and term restorations thereof, and patent applications, including any
continuations, continuations-in-parts, divisionals thereof, and the like.
	 
	 	1.20	 	[ * ] is defined by reference to [ * ] it [ * ] to [ * ] or [ * ] for a [ * ]

	 	(a)	 	[ * ] means to [ * ] and [ * ] a [ * ] or [ * ] of [ * ]
are [ * ] pursuant to a [ * ] that provides that [ * ] of [ * ] as a [ * ]
from [ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	(b)	 	[ * ] to [ * ] or [ * ] for [ * ] of a [ * ] in [ * ] or [ * ] for the [ * ] of [ * ] the [ * ] in a [ * ] for [ * ] which [ * ] is
[ * ] of this definition [ * ] qualify [ * ]

	 	1.21	 	“RBG IP” means RBG Patents and the related Know How, both as of the Closing
Date.
	 
	 	1.22	 	“RBG Patents” means Patents Controlled by RBG as of the Closing Date that are
listed in Exhibit 1.16.
	 
	 	1.23	 	“Supervax” shall mean the current prophylactic two dose Hepatitis B vaccine
that includes the [ * ] adjuvant. [ * ]
	 
	 	1.24	 	“Supervax Program Products” means all prophylactic Hepatitis B vaccines that
contain all of the following: [ * ] The Supervax Program Products include Supervax.
	 
	 	1.25	 	“Theravax” means a therapeutic Hepatitis B vaccine that contains all of [ * ]
	 
	 	1.26	 	“Theravax Program Products” means all therapeutic Hepatitis B vaccines that
contain all of [ * ] The Theravax Program Products include Theravax.
	 
	 	1.27	 	“Traditional Hepatitis B Vaccine” means any vaccine that contains [ * ] For
the avoidance of doubt, Traditional Hepatitis B Vaccine includes the following
Hepatitis B vaccines registered at Closing: [ * ]

In addition, throughout this Agreement the words “include” (and all conjugations of it), “such
as” and “for example” shall each be deemed to be followed by the words “without limitation,”
“but without limitation,” or similar language against construing the language as limiting.

SECTION 2. CONFIRMATION, AMENDMENT AND TERMINATION OF EXISTING CONTRACTS AMONG THE PARTIES

	 	2.1	 	Confirmation of Existing Contract Obligations. Except for the March 1,
2005 Agreement between RBG, RBNV and Berna (which is terminated by the Share Sale and
Purchase Agreement), and except to the extent specifically modified herein and/or by a
separate amendment attached hereto as an Exhibit, all terms of pre-existing (prior to
the Closing Date) contracts among RBG on the one hand and RBNV, and its Affiliates, on
the other hand the “Existing Contracts;” the Existing Contracts exclude the Definitive
Agreements), are hereby confirmed and remain in full force and effect.
	 
	 	2.1.1	 	The Parties hereby agree that this Agreement sets forth the entire
understanding between the Parties and their Affiliates with respect to the ownership
of, all licenses to, and all rights to use and practice, the RBG IP and the [ * ]
strain (here and everywhere else used in this Agreement where we refer to [ * ] we
mean the strain [ * ] as described in [ * ] Release Testing, Genetic and Product
Characterisation). That is to say, where we refer above to “except to the extent

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	 	 	specifically modified hereunder,” the grants of licenses under and rights to use and
practice the RBG IP set forth in this Agreement is, together with the remainder of
this Section 2.1.1 and Sections 2.4 and 2.5, are intended to supersede all prior
understandings with respect to the ownership of, licenses under, and rights to use
RBG IP and the [ * ] strain, and to set forth the Parties’ entire agreement with
respect to all of the foregoing matters mentioned in this sentence. RBNV and its
Affiliates hereby acknowledge that they have no ownership or license rights in the
RBG IP (excluding the Master Cell Line) and the [ * ] strain other than the license
rights set forth in this Agreement. RBNV acknowledge that they have no financial
interest in the RBG IP or [ * ] strain other than as set forth in Section 2.4 and
2.5.
	 
	 	2.2	 	Termination of Berna Agreement. The Termination Agreement between
Dynavax and Berna, which sets forth the Parties’ mutual agreement to terminate the
License and Supply Agreement, dated November 19, 2003, is attached as Exhibit 2.2.
Thus, such License and Supply Agreement is terminated. Section 2.1 of this Agreement
shall not viewed or deemed in any way to resurrect it.
	 
	 	2.3	 	Assignment of Supervax Trademark Rights. The Supervax Trademark
Assignment Agreement between RBG and Berna is attached as Exhibit 2.3.
	 
	 	2.4	 	Fully Paid-Up License Rights. All Patent and Know-How rights, including
RBG Patents rights, granted to RBNV, RBG, and their Affiliates, in pre-existing
agreements between or among RBNV, RBG and their Affiliates, are hereby paid-up and
royalty-free at the Closing Date. With the exception of (1) any outstanding invoices at
Closing, (2) the arrangements specifically made and/or referenced in the Definitive
Agreements executed at Signing and/or Closing (such as the profit share for Supervax,
the loan repayments, any outstanding accounts payable, any open invoices, and the
payments under Section 2.5) and (3) the [ * ] between RBG and RBNV described in the
October 1, 2005 Addendum to License Agreement (between RBG and GCVC dated June 30,
1998) with respect to the License and Technology Transfer Agreement between [ * ]
sharing arrangement is also referred to at the end of Section 2.5). RBG and RBNV
hereby waive all rights to any and all claims to all monies owed under such
pre-existing agreements. If RBNV or RBG requests in writing, RBG or RBNV, respectively,
shall promptly execute, and deliver to the other, any formal amendment documents
confirming the waiver of any monetary obligations owing thereto and/or to its
Affiliates and specific to the aforesaid pre-existing documents. Such confirmations
must be consistent with this Agreement and the other Definitive Agreements. Such
confirmations shall not have any force of effect to the extent inconsistent with this
Agreement and/or any of the other Definitive Agreements.
	 
	 	2.5	 	RBNV Rights to RBG Third Party License Revenues. RBG shall pay to RBNV
all monies (excluding those already included in RBG’s accounts receivable as of the
Closing Date) received by RBG from third parties pursuant to obligations in license
agreements with RBG, which agreements exist on the Closing (other than current licenses
with RBNV and its Affiliates and specifically

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	 	 	excluding [ * ] and the License and Technology Transfer Agreement between [ * ] )
(“Current Licenses”), to the extent that such monies exceed [ * ] annually after
adjustment for payments owed (a) based on agreements existing at Closing, to other
third parties from such monies (including any royalties due to such other third
parties on in-licensed IP sublicenses to the RBG licensees), and (b) for
intellectual property that becomes licensed under the Current Licenses due to RBG
obtaining control thereof after the Closing Date, to such third parties pursuant to
the written agreement by which RBG obtains such control. For the purposes of
clarity, these payments shall not include any payments received by RBG with respect
to its Supervax Program Products, Theravax Program Products and Cytovax Program
Products. RBNV shall have reasonable audit access to records of such payments on
reasonable terms and at reasonable times. Such audits must be performed by a
reputable certified public accountant, under appropriate obligations of
confidentiality. Such audits shall not be made more frequently than once annually,
no later than three (3) years after the payment period being audited.

     Current Licenses specifically exclude the following:

	 	(a)	 	[ * ]
	 
	 	(b)	 	[ * ]

With respect to such [ * ] the [ * ] referred to in the October 1 2005 Addendum to License
Agreement (between RBG and GCVC dated June 30, 1998) shall continue in full force and
effect.

SECTION 3. SUPERVAX RIGHTS OF FIRST REFUSAL AND FIRST NEGOTIATION

	 	3.1	 	European Countries (other then Low Cost Registration European
Countries). Dynavax, or an Affiliate thereof, shall promptly notify RBNV in writing
within [ * ] of taking its decision to develop the first Supervax Program Product (and
thereafter within [ * ] after it takes such decision with respect to each subsequent
Supervax Program Product not already (at the time of such decision) subject to a
pre-existing third party agreement) for any High Cost Registration European Countries
(“Dynavax Notice”). Dynavax, and/or an Affiliate thereof, shall not [ * ] the (i)
development and commercialization (including marketing and selling), and/or (ii)
distribution and/or sale of such Supervax Program Product(s) for and in High Cost
Registration European Countries until after the Parties have exercised their
commercially reasonable efforts according to this Section 3.1 (unless RBNV fails to
provide within the time period stated in Section 3.1.1 a notice that RBNV wishes to
negotiate with Dynavax or its Affiliate under that Section).
	 
	 	3.1.1	 	Schedule and Procedure. Within [ * ] of receiving notification
pursuant to Section 3.1, RBNV, or an Affiliate thereof, may notify Dynavax in writing
of RBNV’s, or an Affiliate’s, intention to negotiate a development and
commercialization agreement with Dynavax or an Affiliate thereof (the “RBNV

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	 	 	Notice”). If RBNV, or an Affiliate thereof, does not provide the RBNV Notice, then
Dynavax may deem the failure to answer as a negative response and shall be free to
proceed with third-party transactions regarding such Supervax Program Product rights
in any and/or all of the countries mentioned in the Dynavax notice, without
restriction.
	 
	 	3.1.2	 	Within [ * ] of receiving the RBNV Notice, Dynavax, or an Affiliate thereof,
shall provide RBNV with a good faith written proposal for a development and
commercialization agreement (at a term sheet or greater level of detail, but not
required to be at the level of a fully drafted agreement), which may, at Dynavax’s
discretion, [ * ] for such Supervax Program Product in the specific country or
countries (“Dynavax Proposal”).
	 
	 	3.1.3	 	Within [ * ] of receipt by RBNV of the Dynavax Proposal (“Negotiation
Period”), RBNV and Dynavax, or their designated Affiliates, shall exercise their
commercially reasonable efforts to negotiate, [ * ] the terms of such development and
commercialization arrangement, including [ * ] .
	 
	 	3.1.4	 	Dynavax, or an Affiliate thereof, shall not offer more favorable terms, such
as an offer that does not require the sharing of development costs (if the offer to
RBNV included such sharing), than those offered to RBNV under Section 3.1.2 (if a
proposal under such Section was required of Dynavax), within [ * ] from the expiration
of the Negotiation Period, unless those terms have first been offered to, and rejected
by, RBNV, which rejection or approval shall be provided within [ * ] of notification.
A failure to respond within such [ * ] shall be considered a rejection. After such [
* ] period, Dynavax, RBG and their Affiliates shall be free to proceed with
third-party transactions regarding such Supervax Program Products rights in any and/or
all of the countries mentioned in the Dynavax notice, without restriction.

Dynavax is entitled to provide the Dynavax Notice to RBNV with respect to one or more High Cost
Registration European Countries. Dynavax may also choose (in its sole discretion) to include in
the Dynavax Notice Low Cost Registration European Countries, and is not required to proceed
separately, contemporaneously or later under Section 3.2. RBNV is not entitled to pick and
choose among countries in a Dynavax Notice, but rather must respond on a group basis to the
country or countries that is or are included in the Dynavax Notice.

Dynavax is entitled to provide the Dynavax Notice to RBNV with respect to one or more Supervax
Program Products. RBNV is not entitled to pick and choose among Supervax Program Products in a
Dynavax Notice, but rather must respond on a group basis to the Supervax Program Product(s) that
is or are included in the Dynavax Notice.

	 	3.2	 	Asian Countries and Low Cost Registration European Countries. Dynavax,
or an Affiliate thereof, shall promptly notify RBNV in writing within [ * ] of taking
its decision to [ * ] in any Asian Country(ies) and/or Low Cost Registration European
Country(ies). Such decision must only be made if the Supervax Program Product and data
regarding it is such that it shall be at a stage

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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CONFIDENTIAL

	 	 	 	that it would be reasonable to [ * ] it being understood and agreed that if in the
particular country it is customary that [ * ] Dynavax, and/or an Affiliate
thereof, shall not [ * ] any third party for the sale and/or distribution of
Supervax for and in any Asian Country(ies) and/or Low Cost Registration European
Country(ies) until after the Parties have exercised their commercially reasonable
efforts according to this Section 3.2 (unless RBNV fails to provide a notice that it
wishes to negotiate with Dynavax or its Affiliate under Section 3.2.1 within the
deadline stated in such Section in which case Dynavax and RBG are free to proceed
regarding such Supervax Program Product rights for the country(ies) mentioned in the
notice, without restriction).
	 
	 	3.2.1	 	Schedule and Procedure. Within [ * ] of receiving notification
pursuant to Section 3.2, RBNV, or an Affiliate thereof, may notify Dynavax in writing
of RBNV’s, or an RBNV Affiliate’s, intention to negotiate a commercialization agreement
with Dynavax, or an Affiliate thereof, with respect to the Asian Country(ies) and/or
Low Cost Registration European Country(ies) mentioned in Dynavax’s or its Affiliate’s
notice (such notice from RBNV, the “RBNV Notice”). If RBNV, or an Affiliate thereof,
does not provide the RBNV Notice, then Dynavax may deem the failure to answer as a
negative response. In that case, Dynavax and RBG are free to proceed regarding such
Supervax Program Product rights for the country(ies) mentioned in their notice, without
restriction.
	 
	 	3.2.2	 	Within [ * ] of receipt of the RBNV Notice, RBNV and Dynavax, or their
designated Affiliates, shall exercise their commercially reasonable efforts to
negotiate, [ * ] in good faith, the essential terms and conditions of sales and
distribution, including [ * ] .
	 
	 	3.2.3	 	In case negotiations under Section 3.2.2 (if required to be initiated
thereunder) do not result, within the specified [ * ] in an agreement as specified in
Section 3.2.2, Dynavax, or an Affiliate thereof, may [ * ] provided that Dynavax, or
an Affiliate thereof, shall not offer to such third parties more favorable terms than
those offered to RBNV, within [ * ] after the end of discussions under Section 3.2.2
without first offering such more favorable terms to RBNV. RBNV is obliged to respond
yes or no to the more favorable terms within [ * ] A failure to respond within such [
* ] is considered a rejection.

The principles of the last two paragraph of Section 3.1 apply to Section 3.2 as well. To avoid
any doubt, this Section 3.2 does not apply to Supervax Program Product rights for Low Cost
Registration European Countries where such rights for the particular countries have already been
passed upon by RBNV through the mechanism of Section 3.1.

	 	3.3	 	First Negotiation. Dynavax and RBNV agree that, for [ * ] after the
Closing Date, neither Party nor their Affiliates, shall negotiate with any third
parties, without first negotiating and discussing in good faith with each other, any
possible joint development, research, collaboration and/or marketing agreement for [ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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SECTION 4. GRANT OF LICENSES.

	 	4.1	 	Supervax. RBG hereby confirms its exercise of the exclusive (even as to
the grantor) license option in the License Option Agreement Supervax dated November 9,
2005, between RBG and Green Cross Vaccine Corporation (the “Superseded Option”). The
terms of such resulting exclusive license are described in the Exclusive License
Agreement attached hereto as Exhibit 4.1, which terms supersede the Superseded Option.
	 
	 	4.2	 	Master Cell Line and Hepatitis B Surface Antigen [ * ] . Subject to
any pre-existing third party agreements and the terms of this Agreement (including the
covenants specified in Section 6 hereof), RBNV and its Affiliates, hereby with respect
to Section 4.2.1 agree that RBG and Dynavax have, and with respect to Section 4.2.2
grant, and confirm the grant, to RBG and Dynavax, of the following rights:
	 
	 	4.2.1	 	The right to use the Master Cell Line for Hepatitis B surface antigen ([ * ] )
currently in RBG’s possession (including progeny of such cell line) for any and all
permitted purposes, including clinical and commercial production. “Permitted purposes”
in this context means all activities outside the scope of the exclusive license of
Section 4.3.2, other than activities forbidden in Section 6, during the time period
forbidden therein.
	 
	 	4.2.2	 	A non-exclusive license under all Patents (if any) owned, or controlled with
the right to sublicense, by RBNV to develop, make, have made, use, offer to sell, sell,
store and import Hepatitis B surface antigen ([ * ] ) produced on the Master Cell
Line, but while the license of Section 4.3.2 is in effect only outside the scope of the
exclusive license of Section 4.3.2; and excluding activities forbidden in Section 6,
during the time period forbidden therein.
	 
	 	4.2.3	 	Sublicense Rights. The rights and licenses specified in 4.2.1 and
4.2.2 above are sublicensable without RBNV’s and its Affiliates’ consent through one or
more tiers or layers of sublicensees to RBG’s and Dynavax’s Affiliates, third party
contract manufacturers, contract clinical and analytical service providers,
distributors, and commercial development and/or marketing partners (including
licensees).
	 
	 	4.2.4	 	The rights and licenses granted in this Section 4.2 are royalty-free and fully
paid-up as far as any payments to RBNV and its Affiliates are concerned, and are
perpetual.
	 
	 	4.3	 	RBG License Grants to RBNV. Subject to the terms of this Agreement and
any restrictions stated in in-licenses by which RBG acquired Control of any RBG IP that
is not owned by RBG, RBG hereby grants to RBNV and its Affiliates, and RBNV and its
Affiliates shall hereby receive, the following rights:
	 
	 	4.3.1	 	a fully paid-up, royalty-free, non-exclusive, license under RBG IP, in
perpetuity, to develop, make, have made, use, sell, offer to sell, store, import and
export any

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	 	 	and all products, except for Supervax Program Products, Theravax Program Products,
Cytovax Program Products and Heplisav Program Products.

	 	4.3.1.1	 	The exclusion of Supervax Program Products, Theravax Program Product,
Cytovax Program Products and Heplisav Program Products from the foregoing
license means (without limitation) that such license does not extend to the
making and selling of Hepatitis B surface antigen (or any other ingredient
covered by or made using the RBG IP) for inclusion (or under contractual terms
that would permit their inclusion) in any Supervax Program Product(s), Theravax
Program Product(s), Cytovax Program Product(s) and/or Heplisav Program
Product(s). Accordingly, RBNV and their Affiliates shall only supply Hepatitis
B surface antigen, made using RBG IP, and such other ingredients to third
parties under circumstances in which such third parties (and any entities to
which they may transfer such antigen and other ingredients) are legally
forbidden and precluded from making Supervax Program Products, Theravax Program
Products, Cytovax Program Product and Heplisav Program Products using the
supplied quantities of such antigen and other ingredients. Notwithstanding the
foregoing, RBNV and its Affiliates shall not be required to amend their
existing agreements to comply with the restrictions specified in this Section
4.3.1, but shall exert its reasonable diligent efforts, which do not adversely
financially impact RBNV, to include such terms upon amendment thereof and shall
include them on any voluntary extension to the relationship (i.e. one that is
not required without RBNV’s or its Affiliate’s consent under the contract that
exists as of the Closing Date).

	 	4.3.2	 	a fully paid-up exclusive license under RBG IP, to develop, make, use, offer
to sell, store, sell and import Traditional Hepatitis B Vaccines (such as [ * ] and
any combination vaccines (containing two (2) or more vaccines directed against diseases
caused by independent agents) that (a) include a Traditional Hepatitis B Vaccine (such
as [ * ] ), but (b) exclude Heplisav Program Products. Such license shall be exclusive,
even as to Dynavax and RBG, for a term lasting until the longer of the end of ten years
or the life of the last-to-expire applicable RBG Patent.

	 	4.3.2.1	 	The foregoing license explicitly does not extend to the making and selling
of Hepatitis B surface antigen (or any other ingredient covered by or made
using the RBG IP) for inclusion (or under contractual terms that would permit
their inclusion) in any Supervax Program Product(s), Theravax Program
Product(s), Cytovax Program Product(s) and/or Heplisav Program Products.
Accordingly, RBNV and their Affiliates shall only supply Hepatitis B surface
antigen, made using RBG IP, and such other ingredients to third parties under
circumstances in which such third parties (and any entities to which they may
transfer such antigen and other ingredients) are legally forbidden and
precluded from making Supervax Program Products, Theravax Program Products,
Cytovax Program Product and Heplisav Program Products using the supplied
quantities of such

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	 	 	 	antigen and other ingredients. Notwithstanding the foregoing, RBNV and its
Affiliates shall not be required to amend their existing agreements to
comply with the restrictions specified in this Section 4.3.2, but shall
exert its reasonable diligent efforts, which do not adversely financially
impact RBNV, to include such terms upon amendment thereof and shall include
them on any voluntary extension to the relationship (i.e. one that is not
required without RBNV’s or its Affiliate’s consent under the contract that
exists as of the Closing Date).

	 	4.3.3	 	For the avoidance of doubt, the licenses of Section 4.3.1 and 4.3.2 do not in
any way diminish the scope of RBG’s rights to the Supervax Program Products, Theravax
Program Products and Cytovax Program Products.
	 
	 	4.3.4	 	Sublicense Rights and Restrictions. The licenses of both Sections
4.3.1 and 4.3.2 are subject to restrictions on RBG’s ability to license and sublicense
pursuant to pre-existing third-party agreements (i.e. agreements with entities other
than Affiliates). Other than such third party licensing restrictions:

	 	(1)	 	RBNV’s non-exclusive license rights provided in subsection
4.3.1 above are sublicensable in conjunction with the grant of a license or
sublicense under [ * ]
	 
	 	(2)	 	RBNV’s exclusive license rights provided in subsection 4.3.2
above, are sublicensable [ * ] without any requirement that RBNV license other
intellectual property in conjunction with the grant of the sublicense.
	 
	 	(3)	 	To avoid any doubt, any sublicensees under the license of
subsection 4.3.1 and any sublicensees under the license of Section 4.3.2 shall
be subject to the same restrictions as stated in Sections 4.3.1.1 and 4.3.2.1,
respectively, as if such sublicensees were RBNV or an RBNV Affiliate.

	 	4.3.5	 	RBG Obligation to Secure Third Party Licensor Consent. At RBNV’s
written request, RBG shall promptly notify each third party licensor of RBG IP, of
RBG’s obligation under Section 4.3 to sublicense rights in such RBG IP to RBNV, and if
consent or amendment under the appropriate license agreement is required, then RBG
shall [ * ] to obtain written consent from each such third party licensor. Promptly
upon securing each required consent from a third party licensor, if the terms of the
consent are acceptable to RBNV, then the Parties shall execute a formal sublicense
agreement with RBNV providing for (1) the sublicense of RBG IP rights to RBNV, and (2)
the assumption of obligations by RBNV as provided for in such third party license
agreements. If any such sublicense requires the payment of monies to the third party
licensor (including any payment in the form of an amendment that results in a payment
of less money to RBG under the contract than without such amendment), RBNV shall be
informed in writing of such potential financial obligation, and RBNV shall be
responsible for the payment of all such fees to said third party licensor. RBNV shall
be entitled to terminate such sublicense in accordance with its terms, but shall not in
this manner be able to avoid responsible for any non-cancelable sublicensing-related
fees.

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	 	4.3.6	 	Licensed RBG Patent Maintenance. Given the non-exclusive nature of
the license of Section 4.3.1, RBG and Dynavax will be under no requirement to prosecute
or maintain RBG Patents, which do not specifically claim [ * ] If RBG and Dynavax
elect to abandon any RBG Patent, RBG and/or Dynavax will first give RBNV reasonable
notice of such intention and the opportunity to prosecute or maintain such RBG Patent.
In this case, optionally, at RBNV’s sole discretion, RBNV may do so in its own name;
provided that RBG and Dynavax will receive a non-exclusive license to such RBG Patents,
consistent with the licenses granted herein and with any pre-existing third party
agreements (i.e. if 3rd party obligations exist that apply to the practice of the
inventions claimed in the RBG Patents taken over by RBNV, then RBNV must comply with
such 3rd party license obligations respecting such practice). If RBG and Dynavax
choose, as part of a strategic move, to abandon a particular RBG Patent, which does not
claim specifically [ * ] and which would reasonably benefit the RBG Patent portfolio,
then the Parties will diligently [ * ]
	 
	 	4.4	 	Defense of Patent Litigation. If either Party after the Closing is
warned or sued by a third party alleging or charging infringement of any Patents
claiming the licensed Know How or the use thereof by either Party or its Affiliates,
then the Party that was warned or sued shall notify promptly the other Party. Except
only if, as and to the extent otherwise provided in Article 8, each Party shall be
responsible, at its expense, for settling and/or defending such warning, allegation or
charge (including associated litigation) to the extent relating to such Party’s or its
Affiliates’ use of the licensed Know-How. [ * ] Upon a Party’s reasonable request,
the other Party agrees to reasonably assist in any such defense on mutually agreed
reasonable terms, provided that the requesting Party agrees to reimburse the other
Party for the reasonable out of pocket expenses incurred by the other Party for the
provision of such assistance. Dynavax and RBG are considered a single “Party” for
purposes of this Section 4.4.
	 
	 	4.5	 	Patent Enforcement.
	 
	 	4.5.1	 	Notification. In the event that a Party obtains actual knowledge that
a third party’s activities likely infringe one or more of the RBG Patents within the
scope of the exclusive license granted in Section 4.3.2, it shall promptly notify the
other Party of any such likely infringement.
	 
	 	4.5.2	 	Control of Suit:

	 	4.5.2.1	 	As to the infringement of exclusively licensed RBG Patents pursuant to
Section 4.3.2, RBG shall have the first right to effect termination of such
infringement, including bringing suit or other proceedings against the
infringer in its own name and the other Parties hereto shall be kept informed
at all times of all such proceedings taken by RBG. If RBNV, or

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	 	 	 	another Party licensee, requests, such Party may join with RBG as a Party to
the lawsuit or other proceeding in a monitoring capacity only at its own
expense. However, even if RBNV chooses to join the suit in such a
monitoring capacity, RBG shall retain sole control of the prosecution of
such suit or proceedings, as the case may be.
	 
	 	4.5.2.2	 	If (a) RBG elects not to file legal proceedings against a third party within
[ * ] such possible infringing activities, and has not engaged in, or has
terminated, reasonably diligent business discussions to terminate such
infringement, and (b) the infringement involves the commercialization of a
product that competes directly with any then-marketed product of RBNV or any of
its Affiliates, and if the alleged infringement is likely to have a more than
insignificant impact on RBNV’s business in the country(ies) where sales of
allegedly infringing product is occurring, then RBNV shall have the right to
effect termination of such infringement, including bringing suit or other
proceedings against the infringer in its own name. The other Parties hereto
shall be kept informed at all times of all such proceedings taken by RBNV.
RBNV shall not be authorized to make any admission, consent, or other
representation during the proceeding, which would admit the invalidity or
unenforceability of an RBG Patent, without the advice and consent, in writing,
from RBG, which RBG is entitled to withhold in its reasonable discretion. If
RBG (or an RBG Affiliate) requests, such entity may join with RBNV as a party
to the lawsuit or other proceeding at its own expense. In this case, RBNV
shall retain control of the prosecution of such suit or proceedings, as the
case may be, except that RBG shall have the sole right to control the
prosecution of such suit or proceedings as regards all matters affecting
validity and/or enforceability of the RBG Patent(s).

	 	4.5.3	 	Costs and Monetary Recovery: Each Party shall bear all its costs
incurred in connection with such lawsuit or other proceeding. Any monetary recovery
shall first be paid to the Parties (and their Affiliates) to reimburse their legal and
other costs associated with the legal proceeding. [ * ] remaining recovery shall be
paid to or retained by RBNV, [ * ] remaining recovery shall be paid to or retained
by RBG.
	 
	 	4.5.4	 	Disclaimer. Nothing in this Agreement shall be construed as
obligating any Party the right, to proceed against a third party infringer.
	 
	 	4.5.5	 	Area of No RBNV Enforcement Rights. RBNV and its Affiliates shall not
have any right to enforce the RBG Patents outside the scope of the exclusive license in
Section 4.3.2 during the time period while it remains exclusive. Without limitation,
this means that RBNV and its Affiliates have no right to enforce the RBG Patents within
the scope of the non-exclusive license of Section 4.3.1, to the extent broader than the
license of Section 4.3.2 (i.e. outside of any overlap between Section 4.3.1 and Section
4.3.2).

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SECTION 5. TECHNICAL ASSISTANCE AND COOPERATION

	 	5.1	 	Master Cell Line Issues-Cooperation. Dynavax and RBNV acknowledge that
the Master Cell Line is (1) used by RBNV and its Affiliates for the production of
products that are approved by Governmental Authorities, and that are currently on the
market, and (2) is confidential and of crucial importance to the Parties. Accordingly,
[ * ] ensure the best and most informed approach. To avoid any doubt, [ * ] Dynavax
and RBNV further agree to use reasonable efforts to promptly notify the other party of
any and all communications to and from Governmental Authorities relating to the safety
of the Master Cell Line, as well as of any communication and/or concerns expressed by
such regulatory authority relating to the safety, quality or characterization of the
Master Cell Line, and agree to consult promptly with each other to resolve any such
concerns with the FDA or such other Governmental Authorities. The Parties agree to
share all safety, toxicity and tumorogenicity data regarding the Master Cell Line that
any of them (or their Affiliates) generates (or receives or contracts for) [ * ]
	 
	 	5.2	 	Production Technology Assistance. RBG will provide to RBNV and to its
Affiliates reasonable access to assistance regarding the Hepatitis B and Hansensula
polymorpha production technologies as in existence at RBG on the Closing (with no
updating), as follows:
	 
	 	5.2.1	 	Troubleshooting. For a period of [ * ] after Closing, RBG will make
available for general diagnosis and troubleshooting, in each year during this [ * ]
period up to [ * ] at a cost of [ * ] per FTE month, which cost may be adjusted for
inflation every year, plus all travel and related expenses, provided that RBNV provides
RBG at least [ * ] advance notice of such request. [ * ] RBG’s technical personnel
supplied by RBG for such general diagnosis and troubleshooting.
	 
	 	5.2.2	 	Long Term Projects. For a period of [ * ] after Closing, RBG will
make available for long term projects, including training of Parent’s personnel, up to
an aggregate of [ * ] of which no more then [ * ] within [ * ] at a cost of [ * ]
per FTE month, which cost may be adjusted for inflation every year, plus all travel and
related expenses, provided that Parent provides RBG at least [ * ] advance notice of
such request. [ * ] RBG technical personnel supplied by RBG for such long term
projects.
	 
	 	5.2.3	 	The aggregate FTEs stated in Sections 5.2.1 and 5.2.2 are stated collectively
for RBNV and its Affiliates together. They are not each separately entitled to this
number of FTEs.
	 
	 	5.3	 	No Transfer or Supply Obligations. Other than is mentioned in Sections
5.1 and 5.2, there are no obligations for RBG or RBNV to supply each other or their
Affiliates, Know How, products or other materials pursuant to the license grants
herein. Any such existing obligations are hereby waived. The Parties remain free to
contract in writing for new such obligations in the future in their sole discretions.

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SECTION 6. COVENANTS NOT TO COMPETE

	 	6.1	 	[ * ] RBG and Dynavax, for [ * ] after Closing, will not develop and/or
market, and/or license others to develop and/or market, for [ * ] Hepatitis B vaccine,
other than Heplisav Program Products.
	 
	 	6.2	 	[ * ] RBG and Dynavax, for [ * ] after Closing, will not develop and/or
market, and/or license others to develop and/or market, [ * ] other than Heplisav
Program Products.

SECTION 7. REPRESENTATIONS AND WARRANTIES

	 	7.1	 	RBG warrants and represents to RBNV that any and all RBG IP rights licensed
from third parties, which rights are necessary for the research, development,
manufacture, marketing, sale or importation of the products known as (a) [ * ] and/or
(b) HepavaxGene, are sublicensable, and have been sublicensed, to RBNV and its
Affiliates, without the need to secure the prior consent from such third parties.
	 
	 	7.2	 	RBNV, RBG and Dynavax warrant and represent to each other that (i) it has the
full right and authority to enter into this Agreement and to grant the rights granted
herein; (ii) it has not previously granted any rights to third parties in conflict with
the rights and options granted herein; (iii) it shall not violate the law or existing
contractual obligations by executing this Agreement; (iv) it is not bound by any
obligations to third parties that would impair its ability to perform its obligations
or grant the licenses contemplated herein; and (v) it has duly executed this
Agreement. UNLESS OTHERWISE EXPRESSLY PROVIDED FOR IN THIS AGREEMENT, EACH PARTY
DISCLAIMS ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF
MERCHANTABILITY, NON-INFRINGEMENT, PATENT VALIDITY, TECHNICAL FEASIBILITY, FITNESS FOR
ANY PARTICULAR PURPOSE, AND ANY WARRANTIES CONCERNING THE INHERENT PROPERTIES OF KNOW
HOW AND RBG IP SUPPLIED OR LICENSED UNDER THIS AGREEMENT. EACH PARTY MAKES NO WARRANTY
AS TO THE MERCHANTABILITY OF THE PRODUCTS, ITS LICENSED KNOW HOW OR LICENSED PATENTS.

SECTION 8. INDEMNIFICATIONS AND INSURANCE

	 	8.1	 	Licensee Third Party Responsibilities.
	 
	 	8.1.1	 	Dynavax/RBG Responsibility. Dynavax and RBG shall be responsible, and
shall hold RBNV harmless for: (i) all financial obligations to third parties (i.e.
parties that are not Parties hereto and Affiliates thereof) due to the receipt or
exercise by Dynavax or RBG of the rights addressed in section 4.2; and (ii) all
requirements in relation to RBNV’s existing (as of the Closing Date) third-party
licenses, arising out of Dynavax’s or RBG’s receipt or exercise of the rights addressed
in section 4.2 of which RBNV informs Dynavax (i.e. if third-party

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	 	 	 	obligations exist (meaning that they are provided for in a written agreement with a
third party executed before the Closing Date) for the use of the Master Cell Line by
RBG and Dynavax under the license of Section 4.2, then fulfillment of those
obligations shall not be RBNV’s responsibility, but RBNV must inform RBG and Dynavax
of such third-party obligations in order for RBG and Dynavax to be able to fulfill
them). For the avoidance of any doubt, RBNV shall not be liable for any financial
obligations to third parties, including for example upstream royalties or other
payments, arising out of Dynavax’s, RBG’s or their Affiliates’ exercise of rights to
third-party technology the rights in which have been sublicensed hereunder.
	 
	 	8.1.2	 	RBNV/Affiliate Responsibility. RBNV is responsible, and shall hold
RBG and Dynavax harmless for: (i) all financial obligations to third parties (i.e.
parties that are not Parties hereto and Affiliates thereof) due to the receipt or
exercise by RBNV and its Affiliates of the license of subsection 4.3.1 and/or 4.3.2,
and (ii) all requirements in relation to RBG’s existing (as of the Closing Date)
third-party licenses for RBG IP, arising out of RBNV’s or its Affiliates’ receipt or
exercise of the licenses of subsections 4.3.1 and 4.3.2 of which RBG and/or Dynavax
informs RBNV (i.e. if third-party obligations exist (meaning that they are provided for
in a written agreement with a third party executed before the Closing Date) for the
exercise of the licenses of Sections 4.3.2 and 4.3.2 shall not be Dynavax’s nor RBG’s
responsibility, but Dynavax or RBG must inform RBNC of such third-party obligations in
order for RBNV and its Affiliates to be able to fulfill them. For the avoidance of any
doubt, RBG and Dynavax shall not be liable for any financial obligations to third
parties, including for example upstream royalties or other payments, arising out of
RBNV’s or its Affiliates’ exercise of rights to third-party RBG IP sublicensed
hereunder.
	 
	 	8.1.3	 	Cooperation. The Parties shall cooperate in the mechanics of making
payment to any upstream licensors. This includes that the sublicensing Party will
forward payments and reports received from the sublicensed Party to the third-party
licensor, promptly after receipt, and will share promptly all notices of delinquency
and non-payment received.
	 
	 	8.2	 	General Product Indemnification.

	 	(a)	 	Each licensing Party herein (“Licensor”) shall not be liable
for, and each licensed Party herein (“Licensee”) shall defend indemnify and
hold Licensor together with its Affiliates and the directors, officers and
employees of all of them (the “Licensor Indemnitees”) harmless against, any and
all liabilities (including product liability and infringement of third party
Patents insofar as such infringement relates to activities carried out by
Licensee under this Agreement), damages, losses costs, and expenses, including
reasonable attorney’s fees (collectively “Damages”), resulting in any manner
from third-party claims, demands and actions (collectively, “Claims”) arising
out of (a) the use by Licensee or its Affiliates of the Master Cell Line and/or
the licensed Know How, or (b) the Licensee’s

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	 	 	 	other activities in exercise of a license granted it hereunder, including
the development or manufacture of licensed (hereunder) prototypes or
clinical supplies by Licensee or its Affiliates, or the use of any licensed
(hereunder) product manufactured, or used by Licensee or its Affiliates by
any human being regardless of whether such use was contemplated by the
Parties, except in the case of each (a) and (b) to the extent such
liabilities result from (x) the willful misconduct, or gross negligence by
the Licensor Indemnitees and/or (y) the Licensor’s breach of its
representations and warranties under this Agreement. For purposes of
illustration, Dynavax shall not be responsible and shall be defended and
held harmless by RBNV for product liabilities relating to [ * ] while RBNV
shall not be responsible for and shall be defended and held harmless by
Dynavax and RBG for product liabilities relating to Supervax Program
Products, Theravax Program Products and Cytovax Program Products. RBG is
the Licensor, and RBNV and its Affiliates are the Licensees, regarding the
licenses of Section 4.3. RBNV is the Licensor, and RBG, Dynavax and their
Affiliates are the Licensees, regarding the licenses of Section 4.2.
	 
	 	(b)	 	RBG hereby agrees to indemnify, defend and hold harmless RBNV
and its Licensor Indemnitees from and against all Damages resulting from Claims
to the extent arising out of (1) a breach of RBG’s representations and
warranties under this Agreement, and/or (2) RBG Indemnitees’ willful
misconduct, or gross negligence. Likewise, RBNV hereby agrees to indemnify,
defend and hold harmless RBG and its Licensor Indemnitees (including Dynavax
and its people) from and against all Damages resulting from Claims to the
extent arising out of (1) a breach of RBNV’S representations and warranties
under this Agreement, and/or (2) RBNV Indemnitees’ willful misconduct, or gross
negligence.

	 	8.3	 	Indemnification Procedure. If a Party (the “Indemnitee”) intends to
claim indemnification under Section 8, Indemnitee shall promptly notify the other Party
(the “Indemnitor”) of any claim, demand, action, or other proceeding for which the
Indemnitee intends to claim such indemnification. The Indemnitor shall have the right
to participate in, and to the extent the Indemnitor so desires jointly with any other
Indemnitor similarly noticed, to assume the defense thereof with counsel selected by
the Indemnitor; provided, however, that the Indemnitee shall have the right to retain
its own counsel at Indemnitee’s own expense. The indemnity obligations under this
Article 8 shall not apply to amounts paid in settlement of any claim, demand, action or
other proceeding if such settlement is effected without the prior express written
consent of the Indemnitor, which consent shall not be unreasonably withheld or delayed.
The failure to deliver notice to the Indemnitor within a reasonable time after notice
of any such claim or demand, or the commencement of any such action or other
proceeding, only to the extent actually prejudicial to its ability to defend such
claim, demand, action or other proceeding, shall relieve such Indemnitor of any
liability to the Indemnitee under this Article 8 with respect thereto, but the omission
so to deliver notice to the Indemnitor shall not relieve it of any liability that it
may have to the

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	 	 	 	Indemnitee otherwise than under this Article 8. The Indemnitor may not settle or
otherwise consent to an adverse judgment in any such claim, demand, action or other
proceeding, that diminishes the rights or interests of the Indemnitee without the
prior express written consent of the Indemnitee, which consent shall not be
unreasonably withheld or delayed. The Indemnitee, its Affiliates, and all of their
employees and agents, shall reasonably cooperate with the Indemnitor and its legal
representatives in the investigation of any claim, demand, action or other
proceeding covered by this Section 8.

If the Parties cannot in good faith agree as to the application of Section 8.2 to any
particular Claim, then each Party may the conduct its own defense of such Claim and reserves
the right to claim indemnification (to the extent provided for in Section 8.2) from the
other Party upon resolution of the underlying Claim.

	 	8.4	 	Insurance. Each Party shall maintain insurance against all foreseeable
risks and claims arising from its performance of activities licensed hereunder.
	 
	 	8.5	 	Limitation of Liability. EXCEPT TO THE EXTENT A PARTY MAY BE REQUIRED
TO INDEMNIFY THE OTHER FOR AMOUNTS PAID TO THIRD PARTIES OR AS REGARDS A BREACH OF A
CONFIDENTIALITY OBLIGATION, NEITHER PARTY (NOR ITS AFFILIATES) SHALL BE LIABLE TO THE
OTHER PARTY (NOR ITS AFFILIATES) FOR PUNITIVE, EXEMPLARY, MULTIPLIED OR CONSEQUENTIAL
DAMAGES (SUCH AS LOST PROFITS, OPPORTUNITY COSTS, MISSED BUSINESS OPPORTUNITIES, OR
OTHER THINGS CAUSED BUT NOT PROXIMATELY CAUSED BY ANY BREACH OR DEFAULT UNDER THIS
AGREEMENT, WHETHER THE THEORY OF LIABILITY IS GROUNDED IN CONTRACT, TORT (INCLUDING
NEGLIGENCE) PRODUCT LIABILITY OR OTHERWISE). EACH PARTY HEREBY IRREVOCABLY WAIVES ANY
RIGHT TO SEEK SUCH DAMAGES.

SECTION 9. MISCELLANEOUS

	 	9.1	 	Governing Law. This Agreement will be governed by the laws of [ * ]
(without giving effect to its conflict of law rules and regulations). Any dispute
shall be resolved by arbitration before the London Court of International Arbitration
in accordance with the [ * ] applying the substantive law of [ * ] excluding
conflicts of law rules.
	 
	 	9.2	 	Arbitration Procedure.
	 
	 	 	 	Any controversy, dispute or claim which may arise out of or in connection with
this Agreement, including the exhibits attached hereto, or the interpretation,
enforceability, performance, breach, termination or validity thereof, including
disputes relating to alleged breach or termination of the foregoing, but excluding
any determination as to the infringement, validity or claim interpretation of
Patents of each Party related to the subject matter hereof and/or the misuse and/or

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

18.

 

CONFIDENTIAL

	 	 	 	misappropriation of a Party’s Information, (each a “Dispute”) shall be resolved
by binding arbitration in accordance with the [ * ] except where this rules
conflict with this provision, in which case this provision controls. The
Arbitration shall be held in English and shall take place in London. The Dispute
shall be construed in accordance with the laws of [ * ] exclusive of conflicts of
law rules. The arbitration tribunal shall consist of three neutral arbitrators,
each of whom shall be an attorney who (a) has at least fifteen (15) years of
experience in the biopharmaceutical field in a law firm or corporate law department
of over twenty-five (25) lawyers or (b) was a judge of a court of general
jurisdiction. However: (X) at least one of the arbitrators must be an attorney
described in clause (a) of the foregoing sentence; (Y) at least one of the
arbitrators must be trained in [ * ] and have been admitted to practice in [ * ] ;
and (Z) at least one of the arbitrators must be a native English speaker. The
arbitrators shall be neutral, independent, disinterested, and impartial. Each Party
shall nominate in the request for arbitration and the answer thereto one arbitrator
and the two arbitrators so named will then jointly appoint the third arbitrator as
chairman of the arbitration tribunal. After appointment, the Parties shall have no
ex-parte communication with their proposed arbitrator. If one Party fails to
nominate its arbitrator or, if the Parties’ arbitrators cannot agree on the person
to be named as chairman within [ * ] the President of the London Court of
International Arbitration shall make the necessary appointments. Within [ * ] of
initiation of arbitration, the Parties shall reach agreement upon and thereafter
follow procedures assuring that the arbitration will be concluded and the award
rendered within no more than eight months from selection of the arbitrators.
Failing such agreement, the Arbitration Rules of the London Court of International
Arbitration will control the procedures and scheduling and the Parties will follow
procedures that meet such a time schedule. Each Party has the right before or, if
the arbitrators cannot hear the matter within an acceptable period, during the
arbitration to seek and obtain from the appropriate court provisional remedies such
as attachment, preliminary injunction, replevin, etc., to avoid irreparable harm,
maintain the status quo or preserve the subject matter of the arbitration. Any
request for such provisional measures by a Party to a court shall not be deemed a
waiver of this agreement to arbitrate. In addition, the Arbitrator Tribunal may, at
the request of a Party, order provisional or conservatory measures (including,
without limitation, preliminary injunctions to prevent breaches hereof) and the
Parties shall be able to enforce the terms and provisions of such orders in any
court having jurisdiction. The decision of the arbitration tribunal must be in
writing and must specify the basis on which the decision was made, and the award of
the arbitration tribunal shall be final and judgment upon such an award may be
entered in any competent court or application may be made to any competent court for
judicial acceptance of such an award and order of enforcement. AS IS CONSISTENT
WITH SECTION 8.5, THE ARBITRATOR SHALL BE EMPOWERED TO AND SHALL NOT AWARD ANY PARTY
PUNITIVE, EXEMPLARY, MULTIPLIED OR CONSEQUENTIAL DAMAGES (SUCH AS LOST PROFITS,
OPPORTUNITY COSTS, MISSED BUSINESS OPPORTUNITIES, OR OTHER THINGS CAUSED BUT NOT
PROXIMATELY CAUSED BY ANY BREACH OR

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

19.

 

CONFIDENTIAL

	 	 	 	DEFAULT UNDER THIS AGREEMENT, WHETHER THE THEORY OF LIABILITY IS GROUNDED IN
CONTRACT, TORT (INCLUDING NEGLIGENCE) PRODUCT LIABILITY OR OTHERWISE), AND EACH
PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT TO SEEK SUCH DAMAGES. NO PARTY MAY SEEK
OR OBTAIN PREJUDGMENT INTEREST OR ATTORNEY’S FEES OR COSTS.
	 
	 	9.3	 	Notice and Reports. All notices required by this Agreement shall be in
writing. All notices and reports shall be sent by fax followed by overnight courier to
the Parties at the following addresses or such other addresses as may be designated in
writing by the respective Parties:

	 	 	 	 	 
	 

	 	To RBNV:
	 	Rhein Biotech NV
	 

	 	 	 	Oude Maasstraat 47,
	 

	 	 	 	NL 6229 BC Maastricht,
	 

	 	 	 	The Netherlands
	 

	 	 	 	[ * ]
	 
	 	 	 	 
	 

	 	To RBG:
	 	Rhein Biotech GmbH
	 

	 	 	 	Eichsfelder Strasse 11
	 

	 	 	 	Dusseldorf 40595
	 

	 	 	 	Germany
	 

	 	 	 	[ * ]
	 
	 	 	 	 
	 

	 	To Dynavax:
	 	Dynavax Technologies Corporation
	 

	 	 	 	2929 Seventh Street, Suite 100
	 

	 	 	 	Berkeley, CA 94710
	 

	 	 	 	USA
	 

	 	 	 	[ * ]
	 

	 	 	 	ATTN: CEO
	 
	 	 	 	 
	 

	 	 	 	With a required copy to Dynavax at the same
address and fax, to “ATTN: LEGAL DEPARTMENT.”

Any notices shall be deemed given when received by the other Party, including in the case of
notices sent by facsimile, if the sender has a valid confirmation of the facsimile going through.

	 	9.4	 	Priority of Agreement. The Parties agree and acknowledge that this
Agreement supersedes any and all prior written or oral agreements between the Parties
and any of their affiliates concerning the subject matter of this Agreement. In
particular, this Agreement supersedes the Letter of Intent in all respects regarding
the subject matter of this Agreement. The Letter of Intent shall not be used to
interpret or deemed to limit or modify the terms of this Agreement. However, the
Confidentiality Agreement will remain in effect and will not be superseded by this
Agreement; provided, however, that information exchanged between the Parties

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

20.

 

CONFIDENTIAL

	 	 	 	(with each Party for this purpose being deemed to include its Affiliates) shall be
deemed exchanged under the Confidentiality Agreement) and protected thereunder; and
provided, further, that notwithstanding any restriction on use stated in such
Confidentiality Agreement, the right of a Party and its Affiliates to use items of
confidential information, materials and know-how as stated in this Agreement shall
not be restricted by such Confidentiality Agreement within the scope of a right or
license granted hereunder to such Party and its Affiliates and instead the Parties’
(and their Affiliates’) rights stated in this Agreement shall prevail. This
Agreement and the Exclusive License Agreement between Green Cross and RBG and the
Trademark Assignment Agreement both signed on the Closing Date together state the
Parties entire agreement with respect to Supervax Program Products, as if they were
a single agreement, with none of such agreement superseding any of the others of
them.
	 
	 	9.5	 	Assignability. This Agreement may not be assigned without the prior
written consent of the other Party, except (i) to an Affiliate, (ii) upon merger of a
Party, or (iii) upon the sale of all or substantially all of Licensee’s assets relating
to the manufacture of antibodies or proteins. Any attempted assignment contrary to the
terms of this provision shall be void.
	 
	 	9.6	 	Force Majeure. Neither Party or its Affiliates shall be liable for any
unforeseeable event beyond its reasonable control not caused by the fault or negligence
of such Party, which causes such Party to be unable to perform its obligations under
this Agreement, and which it has been unable to overcome by the exercise of due
diligence. In the event of the occurrence of such a force majeure event, the Party
unable to perform shall promptly notify the other Party. It shall further use its best
efforts to resume performance as quickly as possible and shall suspend performance only
for such period of time as is necessary as a result of the force majeure event
	 
	 	9.7	 	Expenses. Each Party shall bear its own expenses, if not expressly
agreed otherwise in this Agreement.
	 
	 	9.8	 	Amendment and Waiver. This Agreement may be amended or modified only
by a writing executed by each of the Parties. No waiver of any breach of this Agreement
will be deemed to constitute a continuing waiver of any subsequent breach, whether of
the same or of any other provision hereof.
	 
	 	9.9	 	Severability. If any provision of this Agreement is held or found to
be unenforceable, such provision shall be deemed severed and stricken from this
Agreement, but the remainder of this Agreement shall under all circumstances remain in
full force and effect. The Parties intend that even is a provision is found to be
unenforceable and thus deemed severed and stricken from this Agreement, the remaining
terms of this Agreement shall continue in effect in all cases, and there shall be no
right to rescind or terminate this Agreement.
	 
	 	9.10	 	Counterparts. This Agreement may be executed in multiple counterparts,
each

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

21.

 

CONFIDENTIAL

	 	 	 	of which will constitute an original, but all of which when taken together will
constitute a single agreement. Delivery of an executed counterpart signature page
of this Agreement by facsimile, email or other electronic transmission will be
effective as delivery of a manually executed counterpart of this Agreement.

{REMAINDER OF PAGE INTENTIONALLY BLANK}

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

22.

 

CONFIDENTIAL

THIS AGREEMENT HAS BEEN EXECUTED BY DYNAVAX, RBG AND RBNV, TO HAVE EFFECT ON THE DATE FIRST WRITTEN
ABOVE ON THE FIRST PAGE OF THIS AGREEMENT.

	 	 	 	 	 
	For RBNV:	 	 
	 
	 	 	 	 
	By:

	 	/s/ P.G.J. Heijmanns	 	 
	 

	 	 	 	 
	Name:

	 	P.G.J. Heijmanns	 	 
	Title:

	 	Managing Director	 	 
	 
	 	 	 	 
	For Dynavax:	 	 
	 
	 	 	 	 
	By:

	 	/s/ Dino Dina	 	 
	 

	 	 	 	 
	Name:

	 	Dino Dina, M.D.	 	 
	Title:

	 	President and CEO	 	 
	 
	 	 	 	 
	For RBG:	 	 
	 
	 	 	 	 
	By:

	 	/s/ Frank Ubags	 	 
	 

	 	 	 	 
	Name:

	 	Frank Ubags	 	 
	Title:

	 	CEO	 	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

23.

 

CONFIDENTIAL

Exhibit 1.16

The RBG Patents

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

24.

 

CONFIDENTIAL

Exhibit 2.2

Termination of Berna Agreement 

TERMINATION AGREEMENT

This Termination Agreement (“Agreement”) is made as of the 21st day of April 2006 (hereinafter the
“Effective Date”) by and between

BERNA BIOTECH AG, a Swiss Company having its registered Head Office at Rehhagstrasse 79, CH-3018
Bern, Switzerland (“Berna”)

And

DYNAVAX TECHNOLOGIES CORPORATION, a USA corporation having its offices at 2929 Seventh Street,
Suite 100, Berkeley, CA 94710 USA (“Dynavax”).

(With each of Berna and Dynavax, referred individually as a “Party” and collectively as the
“Parties”).

WITNESSETH

WHEREAS, Berna is the owner of 100 per cent of the share capital of Rhein Biotech NV (hereinafter
“RBNV”), which prior to the Effective Date owned 100 percent of the share capital of Rhein Biotech
GmbH (hereinafter “RBG”);

WHEREAS, Berna and Dynavax are parties to the License and Supply Agreement dated November 19, 2003
(“November 19 Agreement”), a copy of which is attached hereto as Exhibit 1;

WHEREAS, Dynavax is purchasing RGB, and RBNV is selling RGB to Dynavax;

WHEREAS, the sale of RBG to Dynavax is conditioned on the Parties’ mutual termination of the
November 19, 2003 Agreement on the terms and conditions set forth in this Termination Agreement;

NOW THEREFORE, in consideration of the premises, the mutual understandings and the obligations
herein contained, and intending to be legally bound, the Parties do hereby agree as follows,:

	 	1.	 	Pursuant to Section 15.2 of the November 19 Agreement, the Parties mutually
agree to terminate the November 19 Agreement as of the Effective Date.
	 
	 	2.	 	With the exceptions of (a) any payments already made under the November 19
Agreement, (b) any payments due and owed as of Closing to Berna, and (c) the Parties’
obligations under Section 14 of the November 19 Agreement, all financial and other
obligations based on the November 19 Agreement are forever waived and forgiven.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

25.

 

CONFIDENTIAL

	3.	 	Without limiting the generality of the foregoing, neither Party shall be bound
by the surviving Sections 4.4 thorough 4.9, 8, 9 through 13 and 16 of the November 19
Agreement, notwithstanding Section 15.6 of the November 19 Agreement. The
confidentiality clause 14 shall, however, survive termination.

	4.	 	Any and all rights of the Parties relating to the subject matter of the
November 19 Agreement, shall be only as set forth in the Definitive Commercial
Agreement dated as of the Effective Date, among Dynavax, RBG and Rhein Biotech NV.

(Signature page follows)

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

26.

 

CONFIDENTIAL

IN WITNESS WHEREOF, the Parties hereto have caused this instrument to be executed, in two copies,
each an original, by their respective duly authorized officers and representatives with effect as
of the date first above written.

DYNAVAX TECHNOLOGIES CORPORATION

	 	 	 	 	 	 	 	 	 
	/s/ Dino, Dina	 	 	 	 	 	 
	 
	By:

	 	Dino Dina, M.D.
	 	 	 	By:	 	blank
	 

	 	 	 	 	 	 	 	 
	Title:

	 	President & CEO
	 	 	 	Title:	 	blank
	 

	 	 	 	 	 	 	 	 
	Date:

	 	blank
	 	 	 	Date:	 	blank
	 

	 	 	 	 	 	 	 	 

BERNA BIOTECH AG

	 	 	 	 	 	 	 	 	 
	/s/ René Beukema	 	 	 	 	 	 
	 
	By:

	 	René Beukema
	 	 	 	By:	 	blank
	 

	 	 	 	 	 	 	 	 
	Title:

	 	General Counsel & Corporate	 	 	 	 	 	 
	 

	 	Secretary of Crucell Holland, B.V.
	 	 	 	Title:	 	blank
	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Date:

	 	21 April, 2006
	 	 	 	Date:	 	blank
	 

	 	 	 	 	 	 	 	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

27.

 

CONFIDENTIAL

Exhibit 2.3

Supervax Trademark Assignment Agreement

TRADEMARK ASSIGNMENT AGREEMENT

 

This Trademark Assignment Agreement (“Agreement”) is made as of the .... day of March 2006
(hereinafter the “Effective Date”) by and between

BERNA BIOTECH AG, a Swiss Company having its registered Head Office at Rehhagstrasse 79, CH-3018
Bern, Switzerland (“Assignor”)

And

RHEIN BIOTECH GmbH, formed and in good standing under the laws of Germany, having its seat in
Dusseldorf, Eichsfelder Strasse 11, 40595, Germany, (“Assignee”);

WITNESSETH

WHEREAS, Assignor has adopted, and used, the mark “SUPERVAX” (hereinafter the “Trademark”), which
it has registered worldwide. Attached Exhibit 1 identifies the specific registrations by country;

WHEREAS, Assignor has exclusively licensed, on a worldwide basis, the Trademark to Assignee in a
Trademark License Agreement having the Effective Date of October 24, 2005;

WHEREAS, Assignor is selling its equity interest in Assignee to another Party, and as a
consequence, is willing to assign the Trademark to Assignee, and Assignee is willing to acquire
title to such Trademark;

NOW THEREFORE, in consideration of the premises, the mutual understandings and the obligations
herein contained, and intending to be legally bound, Assignor and Assignee do hereby agree as
follows,:

	 	1.	 	For good and valuable consideration, the receipt of which is hereby
acknowledged, Assignor does hereby assign to Assignee all rights, title and interest in
and to said Trademark, the goodwill of the business symbolized by said mark, along with
the registrations thereof worldwide.
	 
	 	2.	 	Assignor shall cooperate with all of Assignee’s reasonable requests for the
execution of formal documents, which Assignee may require to record its title to said
registrations with, and assume responsibilities for representation before, the
trademark office authorities of the various countries in which the Trademark is
registered.
	 
	 	3.	 	As of Closing, Assignee shall assume all responsibilities for the filing,
prosecution, and maintenance of the Trademark worldwide.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

28.

 

	 	4.	 	The terms and conditions of this Assignment Agreement, including the
Attachments hereto, constitute the entire agreement and understanding of the Parties,
supersede all previous communications, whether oral or written, between the Parties,
including any previous agreement or understanding varying or extending the same. There
are no further or other agreements or understandings, written or oral, in effect
between the Parties with respect to the subject matter hereof.
	 
	 	5.	 	This Agreement may be released, discharged, abandoned, changed or modified in
any manner, only by an instrument in writing of equal formality, signed by the duly
authorized officer or representative of the Parties.
	 
	 	6.	 	Notices. All notices required by this Agreement shall be in writing.
All notices shall be sent by fax followed by overnight courier to the Parties at the
following addresses or such other addresses as may be designated in writing by the
respective Parties:

	  	To Berna: 	 	Berna Biotech AG

Rehhagstrasse 79

CH-3018 Berne

Switzerland

[ * ]
	 
	 	To RBG:	 	 Rhein Biotech GmbH

Eichsfelder Strasse 11

Dusseldorf 40595

Germany

[ * ]

	 	 	 	Any notices shall be deemed given when received by the other Party.
	 
	 	7.	 	Force Majeure. No Party, or its Affiliates, shall be liable for any
failure or delay in performance under this Agreement which is due in whole or in part
directly or indirectly to any cause of any nature beyond the reasonable control of such
Party or its Affiliate.

(Signature page follows)

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

29.

 

 CONFIDENTIAL

IN WITNESS WHEREOF, the Parties hereto have caused this instrument to be executed, in two copies,
each an original, by their respective duly authorized officers and representatives with effect as
of the date first above written.

RHEIN BIOTECH GmbH

	 	 	 	 	 	 	 	 	 
	/s/ Frank Ubags	 	 	 	/s/ Z. Janowicz
	 	 	 	 	 
	By:

	 	Frank Ubags
	 	 	 	By:
	 	Z. Janowicz
	Title:

	 	managing director
	 	 	 	Title:
	 	COO
	 
	 	 	 	 	 	 	 	 
	Date:

	 	21 April, 2006
	 	 	 	Date:
	 	21 April, 2006

BERNA BIOTECH AG

	 	 	 	 	 	 	 
	/s/ René Beukema	 	 	 	 
	 	 	 	 	 
	By:

	 	René Beukema
	 	 	 	By:    blank
	Title:

	 	General Counsel & Corporate	 	 	 	 
	 

	 	Secretary of Crucell Holland, B.V.
	 	 	 	Title:  blank
	 
	 	 	 	 	 	 	 	 
	Date:

	 	21 April 2006
	 	 	 	Date:  blank

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

30.

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