Document:

Exhibit 10.1

                   2003 Ameren Executive Incentive Plan (EIP)
                               Ameren Corporation

The Ameren Executive Incentive Plan (EIP) is intended to reward contributions to
Ameren's shareholder value.

PLAN PARTICIPATION
All applicable members of the Ameren Leadership Team are eligible to participate
in the EIP.

PLAN FUNDING
Plan funding is the total amount of incentive money available to award. The plan
is funded based on the  achievement of Ameren  Corporation's  earnings per share
(EPS) for the plan year  (achievement  levels may be adjusted to reflect refunds
and rate changes under regulatory sharing plans or other extraordinary  one-time
events).  Three  levels  of  EPS  achievement  will  be  established  to  reward
participants for progress  achieved in overall EPS  performance.  Achievement of
EPS falling  between the  established  levels  will be  interpolated.  The three
levels are defined as:

1.   Threshold: This is the minimum level of corporate financial achievement for
     incentive awards to be available.  Since the payment of incentives reflects
     a large cost to the organization,  Ameren must achieve this level of EPS to
     justify the payment in respect to our owners, the shareholders.

2.   Target: This is Ameren's targeted level of financial  achievement.  This is
     the level our shareholders and Wall Street expect Ameren to achieve.

3.   Maximum:  This  level  shares  higher  rewards  in years of high  financial
     success.  This level will be very  difficult  to  achieve,  but in years of
     outstanding performance, executives will share in Ameren's success.

BONUS AWARD OPPORTUNITIES
Annual  bonus  award  opportunity  percentages  are set by the  Human  Resources
Committee of the Board of Directors.

PERFORMANCE COMPONENT WEIGHTINGS
There are two performance components (or measures) of the plan: EPS and Business
Line  KPIs/Individual.  The  performance  components  are the  measures  used to
determine  a bonus  award  pay-out.  Each  component  is  weighted.  This weight
indicates  how  much  of the  available  funding  will  be  available  for  each
component.

The weightings for the 2003 plan are:
                            EPS                              50%
                            Business Line KPIs/Individual    50%

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     EPS:  This  component  is the  corporate  level  of  measurement;  Ameren's
     earnings per share achievement.  Fifty percent of the available bonus funds
     will be available for payment to each executive based on corporate success.

     Business  Line/Individual:  Each executive will have 50% of their available
     bonus  determined  by the success of their  individual  contributions.  The
     success of their respective  business line or function's  compensation KPIs
     will be used as the basis of the assessment.

PLAN PAYMENT
Awards will be paid by 3/15/2004.  The bonus award  percentage  will be based on
each  executive's  base salary as of  12/31/2003.  Payment  will be prorated for
participants  who become  eligible after  1/1/2003 or who retire,  die or become
disabled  during  2003.  The salary  basis for those who  retire,  die or become
disabled will be as of the date of retirement,  death or  disability.  The Human
Resources  Committee of the Board of Directors  will approve the final amount of
payment upon recommendation of the CEO of Ameren Corporation.Amendment to Loan Documents

 
EXHIBIT 10.45

Silicon Valley Bank 
 
Amendment to Loan Documents 
 

	Borrower:	 	APPLIED IMAGING CORP. 

	Address:	 	2380 Walsh Avenue 

	        	 	Santa Clara, CA 95051 

 
Dated as of January 31, 2003 
 
THIS AMENDMENT TO LOAN DOCUMENTS is entered into between Silicon Valley Bank (“Silicon”) and the borrower named above
(“Borrower”). 
 
Silicon and Borrower
hereby agree to amend the Loan and Security Agreement between them, dated September 28, 2001 (as amended, restated, supplemented, or otherwise modified from time to time, the “Loan Agreement”), as follows, effective as of the date hereof.
(Capitalized terms used but not defined in this Amendment shall have the meanings set forth in the Loan Agreement.) 
 
1.    Modification of TNW Base Amount and TNW Capital Increase.    The portion of Section 5 of the Schedule
to Loan Agreement that currently reads as follows: 
 
The term “TNW Base Amount” means, as of any date of determination, the amount set forth below corresponding to the time period set forth below: 
 
(A)  during the period commencing on October 1, 2002 and ending on October 31, 2002, $3,500,000;

 
(B)  during the period commencing on
November 1, 2002 and ending on November 30, 2002, $3,200,000; 
 
(C)  during the period commencing on December 1, 2002 and ending on December 31, 2002, $4,800,000; 
 
(D)  during the period commencing on January 1, 2003 and ending on January 31, 2003, $4,000,000; 
 

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(E)  during the period commencing on February 1, 2003 and ending on February 28, 2003, $3,600,000; 
 
(F)  during the period commencing on March 1, 2003 and ending on March 31, 2003, $5,000,000; 
 
(G)  during the period commencing on April 1, 2003
and ending on April 30, 2003, $4,300,000; 
 
(H)  during the period commencing on May 1, 2003 and ending on May 31, 2003, $4,000,000; 
 
(I)  during the period commencing on June 1, 2003 and ending on June 30, 2003, $5,500,000; 
 
(J)  during the period commencing on July 1, 2003
and ending on July 31, 2003, $5,000,000; 
 
(K)  during the period commencing on August 1, 2003 and ending on August 31, 2003, $4,500,000; 
 
(L)  from and after September 1, 2003, $5,500,000. 
 
The term “TNW Capital Increase” means, as of any date of determination, the greater of (a) $-0- and
(b) 50% of all consideration (if any) received after the date of this Agreement for equity securities and subordinated debt of the Borrower. In no event shall the amount of the TNW Capital Increase be decreased. 
 

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, hereby is amended and
restated in its entirety to read as follows: 
 
The term “TNW Base Amount” means, as of any date of determination, the amount set forth below corresponding to the time period set forth below: 
 
(A)  during the period commencing on October 1, 2002 and ending on October 31, 2002, $3,500,000;

 
(B)  during the period commencing on
November 1, 2002 and ending on November 30, 2002, $3,200,000; 
 
(C)  during the period commencing on December 1, 2002 and ending on December 31, 2002, $4,800,000; 
 
(D)  during the period commencing on January 1, 2003 and ending on January 31, 2003, $2,800,000; 
 
(E)  during the period commencing on February 1,
2003 and ending on February 28, 2003, $2,200,000; 
 
(F)  during the period commencing on March 1, 2003 and ending on March 31, 2003, $3,300,000; 
 
(G)  during the period commencing on April 1, 2003 and ending on April 30, 2003, $2,600,000; 
 
(H)  during the period commencing on May 1, 2003
and ending on May 31, 2003, $2,100,000; 
 
(I)  during the period commencing on June 1, 2003 and ending on June 30, 2003, $3,600,000; 
 
(J)  during the period commencing on July 1, 2003 and ending on July 31, 2003, $2,900,000; 
 
(K)  during the period commencing on August 1, 2003
and ending on August 31, 2003, $2,300,000; 
 
(L)  from and after September 1, 2003, $4,200,000. 
 

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The term
“TNW Capital Increase” means, as of any date of determination, the greater of (a) $-0- and (b) 50% of all consideration (if any) received after January 31, 2003 for equity securities and subordinated debt of the Borrower. In no event shall
the amount of the TNW Capital Increase be decreased. 
 
2.    Modification relative to Copyright Registrations.    The portion of Section 9(3) of the Schedule to Loan Agreement that currently reads as follows: 
 
Except for Embedded Software, maskworks under development,
and other computer software under development, Borrower promptly will identify to Silicon in writing and register with the United States Copyright Office (i) any maskworks and computer software that generates Receivables from the sale or licensing
thereof or that is otherwise material to the business of Borrower it has, develops or acquires, including those in Exhibit A to the Intellectual Property Security Agreement, within 30 days of the date of execution and delivery of this Agreement, and
(ii) any additional maskworks and computer software rights developed or acquired, including significant revisions, additions or improvements to the maskworks or computer software or revisions, additions or improvements which significantly improve
the functionality of the maskworks or computer software, after the date of execution and delivery of this Agreement before the sale or licensing to any third party of the maskworks or computer software or any product based on or containing any
maskworks or computer software, and Borrower will execute such additional security agreement(s) and other documentation which Silicon deems necessary for filing with respect to such additional registered copyright(s). 
 
, hereby is amended and restated in its entirety to read as follows:

 
As of February     , 2003,
none of Borrower’s maskworks, computer software, or other copyrights are registered (or the subject of a pending application for registration) with the United States Copyright Office. Borrower will NOT register with the United States Copyright
Office (or apply for such registration of) any of Borrower’s maskworks, computer software, or other copyrights, unless Borrower has provided Silicon not less than 30 days prior written notice of the commencement of such registration/application
and Borrower has executed and delivered to Silicon such additional security agreement(s) and other documentation which Silicon deems necessary for filing with respect to such additional copyright registration/application. 
 
3.    Limited
Waiver.    Silicon and Borrower agree that solely Borrower’s failure to comply with the Minimum Tangible Net Worth financial covenant set forth in Section 5 of the Schedule to the Loan Agreement for the reporting period
ended December 31, 2002 (the “Designated Default”) hereby is waived. It is understood by the parties hereto, however, that the foregoing 
 

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waiver of the Designated Default does not constitute a waiver of the aforementioned covenant with respect
to any other date or time period, or of any other provision or term of the Loan Agreement or any related document, nor an agreement to waive in the future such covenant with respect to any other date or time period or any other provision or term of
the Loan Agreement or any related document. 
 
4.    Fee.    In consideration for Silicon entering into this Amendment, Borrower shall pay Silicon a fee of $3,500 concurrently with the execution and delivery of this Amendment, which
fee shall be non-refundable and in addition to all interest and other fees payable to Silicon under the Loan Documents. Silicon is authorized to charge said fee to Borrower’s loan account. 
 
5.    Representations
True.    Borrower represents and warrants to Silicon that all representations and warranties set forth in the Loan Agreement, as amended hereby, are true and correct. 
 
[remainder of page intentionally left blank; signature page follows]

 

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6.    General Provisions.    This Amendment, the Loan
Agreement, any prior written amendments to the Loan Agreement signed by Silicon and Borrower, and the other written documents and agreements between Silicon and Borrower set forth in full all of the representations and agreements of the parties with
respect to the subject matter hereof and supersede all prior discussions, representations, agreements and understandings between the parties with respect to the subject hereof. Except as herein expressly amended, all of the terms and provisions of
the Loan Agreement, and all other documents and agreements between Silicon and Borrower shall continue in full force and effect and the same are hereby ratified and confirmed. 
 

	 Borrower:
  
 APPLIED IMAGING CORP.
	 	 	 	 Silicon:
  
 SILICON VALLEY BANK

	
	 By
	 	 /s/    Carl
Hull        

	 	 	 	 By
	 	 /s/    Chitra
Suriyanarayanan        

	 	 	 President or Vice President
	 	 	 	 Title
	 	 Account Manager

	
	 By
	 	 /s/    Barry
Hotchkies        

	 	 	 	 	 	 
	 	 	 Secretary or Ass’t Secretary
	 	 	 	 	 	 

 

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