Document:

14th Amendment to 4th Amended, dated August 15, 2005

 EXHIBIT 10.1 
  
 FOURTEENTH AMENDMENT TO FOURTH AMENDED AND 
 RESTATED REVOLVING CREDIT AND SECURITY AGREEMENT 
  
 THIS FOURTEENTH AMENDMENT TO FOURTH AMENDED AND RESTATED REVOLVING CREDIT
AND SECURITY AGREEMENT (the “Amendment”) is made this 15th
day of August, 2005, by and among WinCup Holdings, Inc., Radnor Chemical Corporation, StyroChem U.S., Ltd., Radnor Holdings Corporation (“Radnor”), Radnor Delaware II, Inc., StyroChem Delaware, Inc., WinCup Texas, Ltd., StyroChem GP,
L.L.C., StyroChem LP, L.L.C., WinCup GP, L.L.C., and WinCup LP, L.L.C. (each individually a “Borrower” and collectively, “Borrowers”), and PNC Bank, National Association (“PNC”), as Lead Arranger and Administrative
Agent (defined below), Fleet Capital Corporation (“Fleet”), as Documentation Agent (defined below) and Lenders (defined below). 
  
 BACKGROUND 
  
 A. On December 26, 2001, Borrowers, the financial institutions which are now or which hereafter become a party thereto (individually, a
“Lender” and collectively, the “Lenders”), and PNC, as agent for Lenders (PNC in such capacity, the “Agent”) entered into a certain Fourth Amended and Restated Revolving Credit and Security Agreement (as amended,
modified, renewed, extended, replaced or substituted from time to time, the “Loan Agreement”) to reflect certain financing arrangements between the parties thereto. The Loan Agreement and all other documents executed in connection
therewith are collectively referred to as the “Existing Financing Agreements.” All capitalized terms not otherwise defined herein shall have the meaning ascribed thereto in the Loan Agreement. In the case of a direct conflict between the
provisions of the Loan Agreement and the provisions of this Amendment, the provisions hereof shall prevail. 
  
 B. Borrowers, Agent and Lenders modified certain definitions, terms and conditions contained in the Loan Agreement pursuant to that (i) certain First
Amendment to Revolving Credit and Security Agreement dated February 4, 2002 to facilitate the execution of a Commitment Transfer Supplement by and between Lenders and Fleet Capital Corporation, (ii) certain Letter Agreement, dated as of
March 21, 2002, among Borrowers, Agent and Lenders, (iii) certain Second Amendment to Revolving Credit, Term Loan and Security Agreement dated March 5, 2003, (iv) certain Third Amendment to Revolving Credit, Term Loan and
Security Agreement dated August 1, 2003, (v) certain Fourth Amendment to Revolving Credit, Term Loan and Security Agreement dated September 12, 2003, (vi) certain Fifth Amendment to Revolving Credit, Term Loan and Security
Agreement dated October 27, 2003, (vii) certain Sixth Amendment to Revolving Credit, Term Loan and Security Agreement dated November 17, 2003, (viii) certain Seventh Amendment to Revolving Credit, Term Loan and Security Agreement
dated March 12, 2004, (ix) certain Eighth Amendment to Revolving Credit, Term Loan and Security Agreement dated April 27, 2004, (x) certain Ninth Amendment to Revolving Credit and Security Agreement dated September 27, 2004,
(xi) certain Tenth Amendment to Fourth Amended and Restated Revolving Credit and Security Agreement dated February 15, 2005, (xii) certain Eleventh Amendment to Fourth Amended and Restated Revolving Credit and Security Agreement dated
March 30, 2005, (xiii) certain Twelfth Amendment to Fourth 

 
Amended and Restated Revolving Credit and Security Agreement dated April 8, 2005; (xiv) certain Letter Agreement, dated as of May 5, 2005,
among Borrowers, Agent and Lenders; and (xv) certain Thirteenth Amendment to Fourth Amended and Restated Revolving Credit and Security Agreement dated June 13, 2005. 
  
 C. The Borrowers have requested and the Agent has agreed to modify certain definitions, terms and conditions in the Loan
Agreement. 
  
 D. The parties have agreed, subject to the terms
and conditions of this Amendment, to modify and amend the Existing Financing Agreements. 
  
 NOW THEREFORE, with the foregoing background hereinafter deemed incorporated by reference herein and made part hereof, the parties hereto, intending to be legally bound, promise and agree as follows: 
  
 1. Upon the Effective Date, the Loan Agreement shall be amended as follows:

  
 (i) The definitions of “Contract
Rate”, “Fixed Charge Coverage Ratio” and “Revolving Interest Rate” contained in Section I shall be deleted in their entirety and replaced as follows: 
  
 “Contract Rate” shall mean the Revolving
Interest Rate. 
  
 “Fixed Charge Coverage
Ratio” for any period shall mean with respect to any fiscal period the ratio of (a) EBITDA minus unfinanced capital expenditures and all distributions and dividends made during such period to (b) all Debt Payments made
during such period. For purposes of this calculation, (i) amounts received by Lenders during any quarter, and from the end of such quarter to the date on which financial statements for such quarter are delivered to the Lenders pursuant to
Section 9.8 hereof, from one or more Capital Events and applied to reduce Revolving Advances not to exceed the amount of such unfinanced capital expenditures, shall reduce the amount of unfinanced capital expenditures subtracted from EBITDA for
such quarter and, without double counting, for any subsequent quarter, and (ii) Borrowers shall be entitled to allocate up to $14,000,000 against unfinanced capital expenditures for fiscal year 2005 from proceeds received from one or more
Capital Events. Borrowers shall be permitted to allocate towards unfunded capital expenditures for fiscal years 2005 and 2006 an additional amount up to the amount of proceeds received in connection with one or more Capital Events occurring after
August 1, 2005 not to exceed $20,000,000. 
  
 “Revolving Interest Rate” shall mean an interest rate per annum equal to (a) the Alternate Base Rate plus fifty (50) basis points with respect to Advances that are Domestic Rate Loans or (b) the sum of
the Eurodollar Rate plus the Applicable Margin with respect to Advances that are Eurodollar Rate Loans. 
  

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 (ii) Section 6.5 of the Loan Agreement shall be deleted in its entirety and replaced
as follows: 
  
 6.5. Fixed Charge Coverage
Ratio for Radnor on a Consolidated Basis. Cause to be maintained a Fixed Charge Coverage Ratio for Radnor on a Consolidated Basis to be calculated at the end of each fiscal quarter, based on the most recent: (i) two fiscal quarters then
ended with respect to the test period ending June 30, 2005; (ii) three fiscal quarters then ended with respect to the test period ending September 30, 2005; and (iii) most recent four fiscal quarters then ended with respect to
the test period ending December 31, 2005 and for each test period thereafter (for purposes of calculating the Fixed Charge Coverage Ratio, the amount of interest expense attributable to the Senior Notes shall be equal to one-quarter of the
annual interest expense for each quarter included in the test period) equal to or greater than the amounts set forth below for the periods set forth below: 
  

			
	 Period  

	  	 Fixed Charge Coverage Ratio      

	 June 30, 2005
	  	.63 to 1.00; and
	 September 30, 2005
	  	.85 to 1.00;
	 December 31, 2005
	  	1.00 to 1.00;
	 March 31, 2006
	  	1.00 to 1.00;
	 June 30, 2006
	  	1.05 to 1.00; and
	 September 30, 2006
 each quarter thereafter
	  	1.15 to 1.00.

  
 (iii)
Section 6.6 shall be deleted in its entirety and replaced as follows: 
  
 6.6. Funded Debt to EBITDA Ratio. Cause to be maintained a Funded Debt to EBITDA Ratio for Radnor on a Consolidated Basis to be calculated at the end of each fiscal quarter, based on the most recent:
(i) three fiscal quarters then ended annualized with respect to the test period ending September 30, 2005; and (ii) most recent four fiscal quarters then ended with respect to the test period ending December 31, 2005 and for each
test period thereafter not greater than the amounts set forth below for the periods set forth below: 
  

			
	 Period  

	  	 Funded Debt to EBITDA Ratio      

	 June 30, 2005
	  	NA
	 September 30, 2005
	  	8.80 to 1.00;
	 December 31, 2005
	  	7.40 to 1.00
	 March 31, 2006
	  	6.60 to 1.00;
	 June 30, 2006
	  	5.50 to 1.00;
	 September 30, 2006
	  	5.00 to 1.00;
	 December 31, 2006
	  	4.50 to 1.00; and
	 March 31, 2007 and each
 quarter thereafter
	  	3.75 to 1.00.

  

 3 

 (iv) Section 7.6 shall be deleted and replaced as follows: 
  
 7.6 Capital Expenditures. Purchase or make any
expenditure for fixed or capital assets (including capitalized leases) in an amount in excess of (i) $20,000,000 (or $30,000,000 in the event that Borrowers repay outstanding Advances by an amount not less than $20,000,000 from the proceeds of
one or more Capital Events occurring after August 1, 2005) during fiscal year ending December 31, 2005 with respect to Radnor on a Consolidated Basis, (ii) $25,000,000 during fiscal year ending December 31, 2006 with respect to
Radnor on a Consolidated Basis and (iii) $20,000,000 during any fiscal year thereafter with respect to Radnor on a Consolidated Basis. 
  
 (v) Section 7.17 shall be deleted and replaced as follows: 
  
 7.17. Senior Notes. At any time, directly or indirectly, pay, prepay, repurchase,
redeem, retire or otherwise acquire or make any payments on account of any principal of, interest on or premium payable in connection with the repayment or redemption of the Senior Notes, or permit any Subsidiary or any Affiliate to, at any time,
directly or indirectly, pay, prepay, repurchase, redeem, retire or otherwise acquire or make any payments on account of any principal of, interest on or premium payable in connection with the repayment or redemption of the Senior Notes, except that
Radnor, any Subsidiary or any Affiliate may pay all regularly scheduled payments of interest on the Senior Notes and principal thereof at maturity, so long as no Event of Default has occurred and is continuing and after giving effect to such payment
Borrowers’ Undrawn Availability is not less than $10,000,000. 
  
 2. Additional Secured Notes. Notwithstanding Sections 7.2 (Creation of Liens) and Section 7.8 (Indebtedness) of the Loan Agreement, Radnor shall be permitted to issue up to an additional $30,000,000 of Secured Notes pursuant to
the Secured Indenture and any supplement thereto. 
  
 3.
Transfer of Intangibles. Anything else to the contrary in the Existing Financing Agreements notwithstanding, Borrowers shall be permitted to sell know-how and trademarks used in connection with the manufacture and sale of StyroChem products
to StyroChem Canada, Ltd. and to StyroChem Finland Oy; provided that, (i) prior to such sale, Borrowers deliver to Agent an appraisal (“Appraisal”), in form and substance satisfactory to Agent, which evidences that the sale price of
such know-how or trademark is equivalent to the fair market value of such asset, (ii) Borrowers receive cash proceeds in an amount equal to the fair market value of any such know-how or trademark as evidenced by the Appraisal, (iii) such
know-how or trademark remains subject to any Liens in favor of Agent and Lenders, (iv) the use of such know-how and trademarks by StyroChem Canada, Ltd. shall be limited geographically solely to Canada, (v) the use of such know-how and
trademarks by StyroChem Finland Oy shall be limited geographically solely to Europe, (vi) the Borrowers shall retain all rights to use such know-how and trademarks, and (vii) all proceeds of such sale shall be paid to the Agent to be
applied to reduce outstanding Advances. 
  

 4 

 4. Representations and Warranties. Each Borrower hereby: 
  
 (a) reaffirms all representations and warranties made to
Agent and Lenders under the Loan Agreement and all of the other Existing Financing Agreements and confirms that all are true and correct as of the date hereof; 
  

(b) reaffirms all of the covenants contained in the Loan Agreement, as amended hereby, and covenants to abide thereby until all
Advances, Obligations and other liabilities of Borrowers to Agent and Lenders, of whatever nature and whenever incurred, are satisfied and/or released by Agent and Lenders; 
  
 (c) represents and warrants that no Default or Event of Default has occurred and is continuing under any of
the Existing Financing Agreements; 
  
 (d)
represents and warrants that it has the authority and legal right to execute, deliver and carry out the terms of this Amendment, that such actions were duly authorized by all necessary corporate, partnership or limited liability company action, as
applicable, and that the officers executing this Amendment on its behalf were similarly authorized and empowered, and that this Amendment does not contravene any provisions of its organizational documents or of any contract or agreement to which it
is a party or by which any of its properties are bound; and 
  
 (e) represents and warrants that this Amendment and all assignments, instruments, documents, and agreements executed and delivered in connection herewith, are valid, binding and enforceable in accordance with their
respective terms. 
  
 5. Conditions Precedent/Effectiveness
Conditions. This Amendment shall be effective upon satisfaction of the following conditions precedent (the “Effective Date”) (all documents to be in form and substance satisfactory to Agent and Agent’s counsel): 
  
 (a) Agent shall have received a fully executed copy of this
Amendment; 
  
 (b) Agent shall have received all
fees which are due and payable to Agent or to the Lenders as required by the Loan Agreement, this Amendment or any fee letter entered into by Borrowers and Agent and/or Lenders; and 
  
 (c) Agent shall have received all other documents, agreements or information as required by Agent in its
sole discretion. 
  
 6. Further Assurances and Affirmative
Covenants. Each Borrower hereby agrees to take all such actions and to execute and/or deliver to Agent and Lenders all such documents, assignments, financing statements and other documents, as Agent and Lenders may reasonably require from time
to time, to effectuate and implement the purposes of this Amendment. 
  
 7. Payment of Expenses. Borrowers shall pay or reimburse Agent and Lenders for their reasonable attorneys’ fees and expenses in connection with the preparation, negotiation and execution of this Amendment and the documents
provided for herein or related hereto. 
  

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 8. Reaffirmation of Loan Agreement. Except as modified by the terms hereof, all of the terms and
conditions of the Loan Agreement and all other of the Existing Financing Agreements are hereby reaffirmed and shall continue in full force and effect as therein written. 
  
 9. Miscellaneous. 
  
 (a) Third Party Rights. No rights are intended to be created hereunder for the benefit of any third party donee, creditor, or
incidental beneficiary. 
  
 (b) Headings.
The headings of any paragraph of this Amendment are for convenience only and shall not be used to interpret any provision hereof. 
  
 (c) Modifications. No modification hereof or any agreement referred to herein shall be binding or enforceable unless in writing and
signed on behalf of the party against whom enforcement is sought. 
  
 (d) Governing Law. The terms and conditions of this Amendment shall be governed by the laws of the Commonwealth of Pennsylvania. 
  
 (e) Counterparts. This Amendment may be executed in any number of counterparts and by facsimile, each
of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. 
  
 (f) Effective Date. This Amendment shall be effective as of June 30, 2005. 
  
 [SIGNATURES TO FOLLOW ON SEPARATE PAGES] 
  

 6 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed and delivered by their duly
authorized officers as of the date first above written. 
  

							
	 RADNOR CHEMICAL CORPORATION
 STYROCHEM DELAWARE, INC.
 RADNOR DELAWARE II, INC.
 STYROCHEM GP, LLC

	 	 	By:	 	 Radnor Chemical Corporation,
 its Sole
Member

	STYROCHEM LP, LLC
	 	 	By:	 	 Radnor Chemical Corporation,
 its Sole Member

	STYROCHEM U.S., LTD.,
	 	 	By:	 	StyroChem GP, LLC, its General Partner
	 	 	  By:	 	 Radnor Chemical Corporation,
 its Sole Member

		
	By:	 	/s/ R. Radcliffe Hastings
	 	 	R. Radcliffe Hastings, Executive Vice President

  

							
	 RADNOR HOLDINGS CORPORATION
 WINCUP
HOLDINGS, INC.
 WINCUP GP, LLC

	 	 	By:	 	 WinCup Holdings, Inc.,
 its Sole Member

	WINCUP LP, LLC
	 	 	By:	 	 WinCup Holdings, Inc.
 its Sole
Member

	WINCUP TEXAS, LTD.
	 	 	By:	 	 WinCup GP, LLC
 its General Partner

	 	 	  By:	 	 WinCup Holdings, Inc.
 its Sole
Member

		
	By:	 	/s/ R. Radcliffe Hastings
	 	 	R. Radcliffe Hastings, Executive Vice President

  
 (Signature
Page to Fourteenth Amendment) 
  

 S-1 

			
	Agents:
	 PNC BANK, NATIONAL ASSOCIATION,
 as
Lead Arranger and Administrative Agent

		
	By:	 	/s/ Janeann Fehrle
	 	 	Janeann Fehrle
	 	 	Vice President and Team Leader

  

			
	 FLEET CAPITAL CORPORATION,
 as
Documentation Agent

		
	By:	 	/s/ Robert Anchundia
	Name:	 	Robert Anchundia
	Title:	 	Vice President

  

			
	Lenders:
	 PNC BANK, NATIONAL ASSOCIATION,
 as
Lender

		
	By:	 	/s/ Janeann Fehrle
	 	 	Janeann Fehrle
	 	 	Vice President and Team Leader
	
	Commitment Percentage: 33.33333332%

  

			
	 FLEET CAPITAL CORPORATION,
 as
Lender

		
	By:	 	/s/ Robert Anchundia
	Name:	 	Robert Anchundia
	Title:	 	Vice President
	
	Commitment Percentage: 27.7777777867%

  
 (Signature
Page to Fourteenth Amendment) 
  

 S-2 

			
	 LASALLE BUSINESS CREDIT, LLC,
 as
Lender

		
	By:	 	/s/ Ellen T. Cook
	Name:	 	Ellen T. Cook
	Title:	 	First Vice President
	
	Commitment Percentage: 27.7777777867%

  

			
	 FIFTH THIRD BANK,
 as
Lender

		
	By:	 	/s/ Donald K. Mitchell
	Name:	 	Donald K Mitchell
	Title:	 	Vice President
	
	Commitment Percentage: 11.1111111067%

  
 (Signature
Page to Fourteenth Amendment) 
  

 S-3Corporate Governance and Voting Agreement

 Exhibit 4.1 
  

CORPORATE GOVERNANCE 
  
 AND 
  
 VOTING AGREEMENT 
  
 THIS CORPORATE GOVERNANCE AND VOTING AGREEMENT (this “Agreement”) is entered as of
                         , 2006 by and among Dr. Patrick Soon-Shiong (“PSS”), and the other
persons executing signature pages hereto (PSS and such other persons, together with any third party related to any PSS Party who hereafter becomes a signatory hereto as contemplated by Section 2.05, the “PSS Parties”), and
American Pharmaceutical Partners, Inc., a Delaware corporation (the “Company”). 
  
 WHEREAS, the Company, American BioScience, Inc., a California Corporation (“ABI”), PSS, and certain other ABI shareholders have entered
into an Agreement and Plan of Merger, dated as of November 27, 2005 (the “Merger Agreement”) pursuant to which, among other things, ABI shall be merged with and into the Company (the “Merger”), and all
outstanding shares of capital stock of ABI shall be converted into the right to receive shares of Company Common Stock, all upon the terms and subject to the conditions set forth in the Merger Agreement; 
  
 WHEREAS, concurrently with the execution of this Agreement, the PSS Parties
are entering into a Registration Rights Agreement dated as of the date hereof (the “RRA”) which, among other things, sets forth certain registration rights granted by the Company to the PSS Parties and certain other recipients of
Company Common Stock pursuant to the Merger; 
  
 WHEREAS,
immediately prior to the Merger, the PSS Parties own approximately 99% of the outstanding shares of ABI capital stock and desire that the Merger be completed pursuant to the Merger Agreement; 
  
 WHEREAS, as an inducement for the Company to enter into the Merger Agreement,
ABI has agreed that it is a condition to the Company’s obligation to consummate the Merger that the PSS Parties execute and deliver this Agreement and thereby establish (a) certain terms and conditions concerning the voting of and future
acquisitions of Company Common Stock by the PSS Parties and their respective Affiliates, and (b) certain other matters concerning the corporate governance of the Company; and 
  
 WHEREAS, certain terms used herein are defined in Article IV hereof. 
  
 NOW, THEREFORE, in consideration of the foregoing and the mutual promises and
agreements contained herein, the parties hereto hereby agree as follows: 
  
 ARTICLE I 
  
 STOCK OWNERSHIP

  
 SECTION 1.01. Acquisitions of Company Common
Stock. Each PSS Party shall not, and shall not permit any of his or its Affiliates to, acquire Beneficial Ownership of any 

 
shares of Company Common Stock, in each case whether by tender offer, market purchase, privately-negotiated purchase, merger or other transaction, through
the use of a derivative instrument or voting agreement, by joining a Group, or otherwise, except for: 
  
 (a) acquisitions of Beneficial Ownership of Company Common Stock pursuant to the Merger; 
  
 (b) acquisitions of Beneficial Ownership of Company Common
Stock approved in advance by a majority of the Outside Independent Directors then in office; 
  
 (c) acquisitions of Beneficial Ownership of Company Common Stock (i) upon the exercise of options to acquire Company Common Stock
held by PSS or any of his Affiliates as of the date hereof or (ii) as a result of the grant of options to acquire Company Common Stock hereafter approved by the Company Board and the Outside Independent Directors or the exercise of any such
options; 
  
 (d) acquisitions of Company Common
Stock that would not cause the PSS Parties and their respective Affiliates collectively to Beneficially Own more than 83.5% of the then-outstanding shares of Company Common Stock; and 
  
 (e) acquisitions of Company Common Stock pursuant to, or after the consummation of, a Qualifying Tender
Offer. 
  
 ARTICLE II 
  
 CORPORATE GOVERNANCE 
  
 SECTION 2.01. Outside Independent Directors. 
  
 (a) At each meeting of the stockholders of the Company, or
in connection with any action by written consent, occurring prior to (but not including) the 2007 Annual Meeting at which at least three Outside Independent Director candidates have been nominated for election by the Company, each PSS Party shall
vote or cause to be voted all of such PSS Party’s Voting Control Shares in favor of the election of three Outside Independent Director candidates. 
  
 (b) Prior to (but not including) the 2007 Annual Meeting, no PSS Party shall permit any of such PSS Party’s Voting Control Shares to
be voted (or permit any written consent to be executed in respect of any of such PSS Party’s Voting Control Shares) in favor of the removal of any Outside Independent Directors, unless after giving effect to the removal of such Outside
Independent Directors and any simultaneous or nearly simultaneous election or appointment of any directors, the Board will include at least three Outside Independent Directors. 
  
 SECTION 2.02. Proxy Solicitation. No PSS Party shall, and each shall not permit its Affiliates to, directly or
indirectly solicit, or be a participant in the solicitation of, proxies from stockholders of the Company for the purpose of opposing a solicitation conducted by or on behalf of the Company or the Company Board; provided, that the foregoing
shall not (a) prevent 

  

 2 

 
any PSS Party or any of its Affiliates, in his, her or its capacity as a stockholder of the Company, from nominating candidates for election as directors of
the Company or presenting proposals for a vote or consent of the stockholders of the Company or (b) restrict the ability of any PSS Party or any of its Affiliates from voting or executing consents in respect of shares of Company Common Stock
Beneficially Owned by a PSS Party or any of its Affiliates (or causing such shares to be voted or consents executed in respect thereof) in their discretion on all matters submitted for a vote or consent of the stockholders of the Company.

  
 SECTION 2.03 Board Action. The Company, subject to the
Company Board’s fiduciary duties, shall take all necessary and desirable actions within its control (including calling special meetings of the Company Board and the stockholders of the Company) to effectuate the provisions and intent of this
Agreement. 
  
 SECTION 2.04. Restrictions on Business
Combinations. No PSS Party shall, or permit any of its Affiliates to, (a) merge or consolidate with or into the Company or any of its majority-owned subsidiaries, or (b) acquire from the Company and/or any of its majority owned
subsidiaries, by purchase, lease, exchange, mortgage, pledge, transfer or other disposition (in one transaction or in a series of related transactions), except proportionately as a stockholder of the Company, assets of the Company or any of its
majority-owned subsidiaries having an aggregate market value equal to 10% or more of either the aggregate market value of all of the assets of the Company determined on a consolidated basis or the aggregate market value of all of the outstanding
shares of Company Common Stock, unless such transaction is approved in advance by a majority of the Outside Independent Directors (and the other directors of the Company Board, to the extent required by applicable law); provided, that the
foregoing shall not apply to prevent any PSS Party or any of its Affiliates from merging (or require the approval of a majority of the Outside Independent Directors in order for any PSS Party or any of its Affiliates to merge) with the Company after
the consummation of a Qualifying Tender Offer. 
  
 SECTION 2.05
No Circumvention. No PSS Party shall, or permit its Affiliates to, take any action, or refrain from taking any action, that would cause any Voting Control Shares to cease to constitute Voting Control Shares prior to the termination of this
Agreement; provided, however, that sales or transfers of Voting Control Shares to unrelated third parties on arm’s-length terms, or transfers to related third parties who as a condition to such transfer execute and deliver a
counterpart signature page hereto and thereby become a PSS Party, shall not be deemed to be a violation of this Section 2.05. 
  
 ARTICLE III 
  
 REPRESENTATIONS AND WARRANTIES 
  
 SECTION 3.01 Representations and Warranties of PSS and the PSS Parties. PSS and each other PSS Party hereby jointly and severally represents and warrants to the Company, as follows: 
  
 (a) Each PSS Party (if it is an entity) is duly incorporated
or otherwise organized, validly existing and in good standing under the laws of its jurisdiction of incorporation or organization is duly qualified or licensed to do business, and is in good 

  

 3 

 
standing, in each jurisdiction where the character of the properties owned, leased or operated by it or the nature of its business makes such qualification,
licensing or good standing necessary, except for such failures to be so duly incorporated or organized, validly existing or in good standing, qualified or licensed that, individually or in the aggregate, would not reasonably be expected to have a
material adverse effect on such PSS Party’s ability to perform its obligations hereunder. 
  
 (b) Each PSS Party (if it is an entity) has all necessary corporate or other power and authority to execute and deliver this Agreement, to
perform its obligations hereunder and to consummate the transactions contemplated hereby. The execution and delivery of this Agreement by each PSS Party (if it is an entity), the performance by such PSS Party (if it is an entity) of its obligations
hereunder and the consummation by such PSS Party (if it is an entity) of the transactions contemplated hereby (i) have been duly and validly authorized by all necessary corporate or other organizational action required on the part of such PSS
Party (if it is an entity) under applicable law or the organizational, constituent or governing documents of such PSS Party (if it is an entity), and (ii) (assuming compliance with all requirements of applicable securities laws and the rules
and regulations of the NASDAQ National Market or any exchange upon which the Company’ securities are listed or traded and that the consents, approvals, authorizations and permits described in Section 4.5(b) of the Company’s disclosure
schedule to the Merger Agreement have been obtained and all filings and notifications described in such section of the Company’s disclosure schedule have been made and any waiting periods thereunder have terminated or expired) no other
consents, approvals, actions, proceedings or authorizations are necessary to authorize the execution and delivery of this Agreement by the PSS Parties or the performance of their respective obligations hereunder, except as would not, individually or
in the aggregate, reasonably be expected to have a material adverse effect on such PSS Party’s ability to perform its obligations hereunder. This Agreement has been duly and validly executed and delivered by each PSS Party and constitutes a
legal, valid and binding obligation of each PSS Party, enforceable against such PSS Party in accordance with its terms, subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicability
relating to or affecting creditors’ rights and to general principles of equity. The trustee(s) listed on the signature page hereof with respect to the respective PSS Parties who are trusts have the full right, power and authority to cause such
trusts to comply with the terms hereof without any instructions, directions, authorizations, or approvals of any beneficiary thereof or any other person, or have obtained all necessary instructions, directions, authorizations, or approvals.

  
 (c) The execution and delivery of this
Agreement by each PSS Party does not, and the performance of this Agreement by the PSS Parties will not, (i) conflict with or violate any provision of the organizational, constituent or governing documents of such PSS Party (if that PSS Party
is an entity), (ii) conflict with or violate any organizational documents of any Affiliate of such PSS Party, or (iii) (assuming compliance with all requirements of applicable securities laws and the rules and regulations of the NASDAQ
National Market or any exchange upon which the Company’ securities are listed or traded and that the consents, approvals, authorizations and permits described in Section 4.5(b) of the Company’s disclosure schedule to the Merger
Agreement have been obtained and all filings and notifications described in such section of the Company’s disclosure schedule have been made and any waiting periods thereunder have terminated or expired) conflict with or violate any contract
binding on or any 

  

 4 

 
statute, law or order applicable to such PSS Party or by which any property or asset of such PSS Party is bound, except as would not, individually or in the
aggregate, reasonably be expected to materially limit or delay such PSS Party’s ability to perform its obligations hereunder. There are no contractual, legal or other restrictions or impediments to the right, authority and ability of the PSS
Parties to agree to and perform, and to cause such respective PSS Parties’ Affiliates to perform, the obligations contemplated hereby, except as would not, individually or in the aggregate, reasonably be expected to materially limit or delay
such PSS Party’s ability to perform its obligations hereunder. 
  
 (d) All shares of Company Common Stock issued to the PSS Parties pursuant to the Merger are Voting Control Shares for purposes of this Agreement. 
  
 SECTION 3.02 Representations and Warranties of the Company. The Company hereby represents and warrants to the PSS
Parties, as follows: 
  
 (a) The Company is a
corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company is duly qualified or licensed to do business, and is in good standing, in each jurisdiction where the character of the properties
owned, leased or operated by it or the nature of its business makes such qualification, licensing or good standing necessary, except for such failures to be so qualified, licensed or in good standing that individually or in the aggregate, would not
reasonably be expected to have a Company Material Adverse Effect (as defined in the Merger Agreement). 
  
 (b) The Company has all necessary corporate power and authority to execute and deliver this Agreement, to perform its obligations
hereunder and to consummate the transactions contemplated hereby. The execution and delivery of this Agreement, the performance by the Company of its obligations hereunder and the consummation by the Company of the transactions contemplated hereby
have been duly and validly authorized by all necessary corporate action on the part of the Company, and no other corporate proceedings on the part of the Company are necessary to authorize this Agreement or to consummate the transactions
contemplated hereby. This Agreement has been duly authorized and validly executed and delivered by the Company and constitutes a legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms,
subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicability relating to or affecting creditors’ rights and to general principles of equity. 
  

 5 

 (c) The execution and delivery of this Agreement by the Company does not, and the
performance of this Agreement by the Company will not, (i) conflict with or violate any provision of the organizational or governing documents of the Company, (ii) conflict with or violate any organizational documents of any of the
subsidiaries of the Company, or (iii) (assuming that all consents, approvals, authorizations and permits described in Section 4.5(b) of the Company’s disclosure schedule to the Merger Agreement have been obtained and all filings and
notifications described in such section of the Company’s disclosure schedule have been made and any waiting periods thereunder have terminated or expired) conflict with or violate any statute, law or order applicable to the Company or any of
its subsidiaries or by which any property or asset of the Company or any of its subsidiaries is bound or affected. 
  
 ARTICLE IV 
  
 DEFINITIONS 
  
 SECTION 4.01
Definitions. The following terms as used herein have the following respective meanings: 
  
 “2007 Annual Meeting” means the annual meeting of the stockholders of the Company held in calendar year 2007. 
  

“Affiliate” with respect to any person means (i) if such person is an individual, any spouse or minor child (natural or by
adoption) of such person; (ii) any trust or family partnership established by such person (if such person is an individual) and/or his or her spouse for the benefit of such person and/or members of his or her immediate family; (iii) the
estate of such person (if such person is an individual); or (iv) any entity that, directly, or indirectly through one or more intermediaries controls, is controlled by or is under common control with, such person. For purposes of this
definition, “control” means the possession, directly or indirectly, of the power to direct the management and policies of the applicable entity, whether through the ownership of voting securities, by contract or otherwise. For purposes of
Section 1.01 of this Agreement and subject to the next sentence, a person shall not be considered an “Affiliate” of a PSS Party for purposes of the provisions of this Agreement obligating a PSS Party to cause its
“Affiliates” to take or refrain certain actions if that PSS Party does not possess, directly or indirectly, the power to cause such person to comply with the requirements of such provision, whether through the ownership of voting
securities, by contract or otherwise. For purposes of this Agreement, neither the Company nor any person controlled by the Company or their respective officers and directors (other than PSS) shall be deemed to be Affiliates of any PSS Party.

  
 “Beneficial Ownership” (and related terms
such as “Beneficially Owns” or “Beneficial Owner”) has the meaning set forth in Rule 13d-3 promulgated under the Exchange Act; provided, however; that for purposes of determining Beneficial Ownership, a person or
entity shall be deemed to Beneficially Own any securities which such person has the right to acquire (irrespective of whether such right to acquire such securities is exercisable immediately or only after the passage of time, the satisfaction of any
conditions, the occurrence of any event or any combination of the foregoing) pursuant to any agreement or upon the exercise of conversion 

  

 6 

 
rights, exchange rights, warrants or options, or otherwise; provided, however, that a person shall not be deemed to Beneficially Own any
securities tendered pursuant to a tender or exchange offer made by such person until such tendered securities are accepted for purchase or exchange by such person. For purposes of this Agreement, no PSS Party or any of their respective Affiliates
shall be deemed to Beneficially Own any securities Beneficially Owned by the Company or any person controlled by the Company or any of their respective officers and directors (other than PSS). Under this Agreement, for purposes of calculating the
percentage of the outstanding shares of Company Common Stock Beneficially Owned by any person or persons, the number of outstanding shares of Company Common Stock shall be deemed to include the total number of basic shares of Company Common Stock
then outstanding plus the number of shares of Company Common Stock issuable upon exercise of stock options which are then “in the money,” calculated as follows: the number of option shares to be counted in shares outstanding is calculated
individually for each tranche of options (e.g. if the company has 100 tranches, a number of shares potentially issued is calculated for each), in each case by multiplying the number of shares subject to options outstanding per tranche by the
difference between the current stock price and the strike price of the applicable tranche of option, and then dividing such number by the then current stock price. For all those tranches for which the strike price is higher than the current
stock price, the shares subject to the options are not considered to be outstanding. 
  
 “Company Board” means the board of directors of the Company and, from and after the effective time of the Merger, the board of directors of the corporation surviving the Merger. 
  
 “Company Common Stock” means shares of common stock, par
value $0.001 per share, of the Company, and any capital stock into or for which such common stock hereafter may be converted or exchanged pursuant to a recapitalization, reclassification, merger or other similar event. 
  
 “Exchange Act” means the Securities Exchange Act of 1934, as
amended, and any Rules promulgated thereunder. 
  
 “Group” has the same meaning as described in Section 13(d)(3) of the Exchange Act. 
  
 “Outside Independent Directors” means any director of the Company (a) who either (i) qualifies as an “independent
director” with respect to the Company pursuant to Section 4200(a)(15) of the Nasdaq National Market Marketplace Rules (as in effect as of the date of the Merger Agreement), or (ii) qualifies as “independent” with respect to
the Company under Rule 10A-3 under the Exchange Act (as in effect as of the date of the Merger Agreement), and (b) whose nomination or appointment was approved by PSS and a majority of the Outside Independent Directors then in office (in each
case such approval not to be unreasonably withheld), it being understood that, for purposes of this clause (b), each of the individuals who is a director of the Company as of the date of the Merger Agreement and who satisfies the requirements of
clause (a) shall be deemed to have been approved by PSS and a majority of the Outside Independent Directors. 
  
 “person” means any individual, corporation, limited liability company, partnership, association, trust, unincorporated organization or
other entity. 
  

 7 

 “Qualifying Tender Offer” means a tender or exchange offer by PSS, one or more
Affiliates of PSS and/or one or more other PSS Parties that (i) is for all of the outstanding shares of Company Common Stock (provided, that such tender or exchange offer need not seek to acquire shares of Company Common Stock
Beneficially Owned by PSS, any of his Affiliates or any of the other PSS Parties); (ii) is subject to a non-waiveable condition that a majority of the then-outstanding shares of Company Common Stock (other than any shares of Company Common
Stock Beneficially Owned by PSS or any of his Affiliates) be validly tendered and accepted for purchase by the offeror; and (iii) includes a commitment by the offeror (to be contained in the offer to purchase pursuant to which the tender or
exchange offer is made) to promptly consummate a merger following the completion of the tender or exchange offer, in which all remaining shares of Company Common Stock not Beneficially Owned by PSS, any of his Affiliates or the PSS Parties shall be
acquired for the same amount and type of consideration as was paid per share of Company Common Stock pursuant to the tender or exchange offer. 
  
 “Voting Control Shares” shall mean, with respect to any PSS Party, any shares of Company Common Stock Beneficially Owned by such PSS
Party or any of its Affiliates over which such PSS Party has the power to vote or control or direct the voting thereof. 
  
 ARTICLE V 
  
 MISCELLANEOUS 
  
 SECTION 5.01. Notices. All notices, requests and other communications to any party hereunder shall be in writing (including faxes or similar writing) and shall be given, 
  
 If to the Company, to: 
  
 American Pharmaceutical Partners, Inc. 
 1501 East Woodfield Road, Suite 300 East 
 Schaumburg, IL 60173-5837 
 Attention: General Counsel 
 Fax: (847) 413-2670 
  
 with a
copy (which shall not constitute notice) to: 
  
 Gibson,
Dunn & Crutcher LLP 
 333 South Grand Avenue 
 Los Angeles, California 90071-3197 
 Attention: Peter Ziegler, Esq. 
 Fax: (213) 229-7520 
  
 and further copies (which shall not constitute notice) to: 
  
 Morrison & Foerster LLP 
 400 Capitol
Mall, Suite 2600 
 Sacramento, California 95814 
 Attention: Charles Farman, Esq. 
 Fax: (415) 268-7522 
  

 8 

 and: 
  
 Morrison & Foerster LLP 
 425 Market
Street 
 San Francisco, California 94105-2482 
 Attention: Michael G. O’Bryan, Esq. 
 Fax: (415) 268-7522 
  
 If to any PSS Party to the address of such party set forth beneath such
party’s signature hereto, 
  
 or such other address or fax number as such
party may hereafter specify for such purpose by notice to the other parties hereto. Each such notice, request or other communication shall be effective (i) if given by fax, when such fax is transmitted to the fax number specified in this
Section and electronic confirmation of transmission is received or (ii) if given by any other means, when delivered at the address specified in this Section. 
  
 SECTION 5.02. Amendments; No Waivers; Enforcement. 
  
 (a) Any provision of this Agreement may be amended or waived
if, and only if, such amendment or waiver is in writing and signed, in the case of an amendment, by PSS and the Company, or in the case of a waiver, by the party against whom the waiver is to be effective; provided, that no such amendment or
waiver on behalf of the Company shall be effective without the approval of (i) a majority of the Outside Independent Directors, or (ii) if no member of the Company Board meets the definition of an Outside Independent Director, a majority
of the members of the audit committee of the Company. 
  
 (b) Any action to be taken by the Company to amend, modify, waive, suspend or enforce its rights under this Agreement shall be taken at the direction of a majority of the Outside Independent Directors or, if no member of the Company Board
meets the definition of an Outside Independent Director, a majority of the members of the audit committee of the Company. 
  
 (c) No failure or delay by any party in exercising any right, power or privilege hereunder shall operate as a waiver thereof nor shall any
single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power or privilege. The rights and remedies herein provided shall be cumulative and not exclusive of any rights or remedies
provided by law. 
  
 SECTION 5.03. Headings. The
headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning or interpretation of this Agreement. 
  
 SECTION 5.04. Severability. If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced under
applicable law or for reasons of public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions contemplated hereby is not
affected in any manner materially adverse to any party. Upon such determination 

  

 9 

 
that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this
Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that transactions contemplated hereby are fulfilled to the extent possible. 
  
 SECTION 5.05. Entire Agreement. This Agreement, the Merger
Agreement and the RRA represent the entire agreement of the parties and supersede all prior or contemporaneous oral or written agreements and undertakings between the parties with respect to the specific collective subject matter hereof and thereof
(it being understood that the execution and delivery hereof shall not affect the validity or enforceability of the Merger Agreement, the RRA and the other documents and instruments executed and delivered concurrently herewith in accordance with the
Merger Agreement’s terms). 
  
 SECTION 5.06.
Assignment. Neither this Agreement nor any of the rights, interests or obligations hereunder shall be assigned by any of the parties hereto, in whole or in part (whether by operation of law or otherwise), without the prior written consent of
the other parties (and, in the case of any such purported assignment by any PSS Party, without the prior written consent of the Outside Independent Directors or, if no member of the Company Board meets the definition of an Outside Independent
Director, a majority of the members of the audit committee of the Company), and any attempt to make any such assignment without such consent shall be null and void ab initio. 
  
 SECTION 5.07. Parties in Interest. This Agreement shall be binding upon and inure solely to the benefit of the
parties hereto and their respective successors and assigns, and nothing expressed or implied in this Agreement is intended to or shall confer upon any other person any right, benefit or remedy of any nature whatsoever under or by reason of this
Agreement. 
  
 SECTION 5.08. Mutual Drafting. Each
party hereto has participated in the drafting of this Agreement, which each party acknowledges is the result of extensive negotiations between the parties. As a result, the parties expressly acknowledge and agree that no principles of contractual
interpretation (whether statutory or under common law) purporting to construe ambiguities against the drafter shall apply to the interpretation, application or enforcement of this Agreement. 
  
 SECTION 5.09. Governing Law; Consent to Jurisdiction; Waiver of Trial
by Jury. 
  
 (a) This Agreement shall be
governed by, and construed in accordance with, the law of the State of Delaware, without regard to its conflicts or choice of law principles. 
  
 (b) Each of the parties hereto hereby irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction
of any Delaware State court, or Federal court of the United States of America, sitting in Delaware, and any appellate court from any thereof, in any action or proceeding arising out of or relating to this Agreement or the transactions contemplated
hereby or for recognition or enforcement of any judgment relating hereto, and each of the parties hereby irrevocably and unconditionally (i) agrees not to commence any such action or proceeding except in such courts, (ii) agrees that any
claim in 

  

 10 

 
respect of any such action or proceeding may be heard and determined in such Delaware State court or, to the extent permitted by law, in such Federal court,
(iii) waives, to the fullest extent it may legally and effectively do so, any objection which it may now or hereafter have to the laying of venue of any such action or proceeding in any such Delaware State or Federal court and (iv) waives,
to the fullest extent permitted by law, the defense of an inconvenient forum to the maintenance of such action or proceeding in any such Delaware State or Federal court. Each of the parties hereto agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by law. Each party to this Agreement irrevocably consents to service of process in the manner provided for notices in
Section 5.01. Nothing in this Agreement will affect the right of any party to this Agreement to serve process in any other manner permitted by Law. 
  

(c) EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND
DIFFICULT ISSUES, AND THEREFORE IT HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT AND ANY OF THE AGREEMENTS
DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (i) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER
PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE EITHER OF SUCH WAIVERS, (ii) IT UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF SUCH WAIVERS, (iii) IT MAKES SUCH WAIVERS VOLUNTARILY, AND (iv) IT HAS BEEN INDUCED TO
ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 5.09(c). 
  
 SECTION 5.10. Counterparts. This Agreement may be executed by facsimile signature and in two or more counterparts, and by the different parties
hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same agreement. 
  
 SECTION 5.11. Specific Performance. The parties hereto agree that irreparable damage would occur in the event that
any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions, without the posting of any
bond, to prevent breaches of this Agreement and to enforce specifically the terms and provisions hereof, this being in addition to any other remedy to which they may be entitled at law or in equity. 
  
 SECTION 5.12 Termination. This Agreement automatically shall
terminate upon the earliest of (a) the date of the 2007 Annual Meeting, (b) the first date upon which the PSS Parties and their respective Affiliates collectively Beneficially Own less than 65% of the then outstanding shares of Company
Common Stock and (c) the date a Qualifying Tender Offer and 

  

 11 

 
the related back-end merger are completed and all outstanding shares of Company Common Stock are owned by PSS or his Affiliates. 
  
 [signature page follows] 
  

 12 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of the day and
year first above written. 
  

			
	PSS
	
	 
	Dr. Patrick Soon-Shiong
		
	 Address:
	 	 
	 
	 
	
	CALIFORNIA CAPITAL LIMITED PARTNERSHIP
		
	By:	 	 Themba, LLC, its General Partner

		
	By:	 	 
	 	 	S. Hassan, Manager
		
	 Address:
	 	 
	 
	 
	
	THEMBA 2005 TRUST I
		
	By:	 	 
	 	 	S. Hassan, Trustee
		
	 Address:
	 	 
	 
	 

  

 13 

			
	THEMBA 2005 TRUST II
		
	By:	 	 
	 	 	S. Hassan, Trustee
		
	 Address:
	 	 
	 
	 
	
	2005 TWO-YEAR ANNUITY TRUST A
		
	By:	 	 
	 	 	S. Hassan, Trustee
		
	 Address:
	 	 
	 
	 
	
	2005 TWO-YEAR ANNUITY TRUST B
		
	By:	 	 
	 	 	S. Hassan, Trustee
		
	 Address:
	 	 
	 
	 
	
	AMERICAN PHARMACEUTICAL PARTNERS, INC.
		
	By:	 	 
	 Name:
	 	 
	 Title:
	 	 

  

 14

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