Document:

<PAGE>   1
                                                                    Exhibit 10.8

                                                           FINAL VERSION 3/15/01

                       AMENDMENT AND SUPPLEMENT TO ASSETS
                     SALE AND PURCHASE AGREEMENT AND RELEASE

         THIS AMENDMENT AND SUPPLEMENT AGREEMENT AND RELEASE (THE "AMENDMENT")
is entered into as of the 28th day of February 2001, by and between ESCALON
MEDICAL CORP., a Delaware corporation ("Escalon"), ESCALON VASCULAR ACCESS, INC.
("Buyer") and RADIANCE MEDICAL SYSTEMS, INC. (formerly CARDIOVASCULAR DYNAMICS,
INC.), a Delaware corporation ("Radiance").

                                   BACKGROUND

         WHEREAS, Escalon, Buyer and Radiance entered into an Assets Sale and
Purchase Agreement (the "Asset Agreement") dated January 21, 1999, and

         WHEREAS, any capitalized term used herein and not defined shall have
the meaning ascribed to it in the Asset Agreement, and

         WHEREAS, the parties wish to amend the Asset Agreement to provide an
adjustment in the terms of payment of the royalties pursuant to Section 2.3(c)
of the Asset Agreement,;

                                   WITNESSETH

         NOW, THEREFORE, in consideration of the respective covenants contained
herein and intending to be legally bound hereby, the parties hereto agree as
follows:

         1.       The last two sentences of Section 2.3(c) of the Asset
Agreement shall be amended to read as follows:

                  "With respect to Net Sales made during each 12-month period
         during the Royalty Period commencing on January 21, 2001, (each such
         period a "Royalty Year"), Buyer shall pay to Seller royalty payments
         under this Section 2.3(c) only with respect to Net Sales in excess of
         $3,000,000 in any Royalty Year."

         2.       Radiance, Escalon and Buyer agree that Buyer owes to Radiance
an additional $182,442 for royalties for the 12 months ended January 21, 2001,
and agree that as payment therefor, and as consideration for the amendment of
Section 2.3(c) of the Asset Agreement set forth above, Escalon and Buyer shall
make the issuances and payments and deliver promissory notes, and agrees to the
obligations, as set forth in Sections 3, 4, 5, 6 and 7 below.

         3.       Escalon shall within three (3) days of the date of this
Amendment issue to Radiance 50,000 shares of Escalon's common stock (to be
valued at $100,000). Radiance understands and acknowledges that (i) the shares
of Escalon Common Stock to be issued to the Radiance pursuant to this Amendment
will be issued under certain
<PAGE>   2
exemptions from the registration provisions of the Securities Act of 1933 (the
"Securities Act"), (ii) Radiance is acquiring the shares of Escalon Common Stock
without being furnished any offering literature or prospectus, (iii) the
issuance of the shares of Escalon Common Stock has not been examined by the
Securities and Exchange Commission (the "Commission") or by any agency charged
with the administration of the securities laws of any state or other
jurisdiction and (iv) it has had the opportunity to review certain materials,
including financial information, regarding Escalon and to ask questions of
officers of Escalon regarding Escalon. Radiance represents and warrants that it
has such knowledge and experience in financial and business matters that it is
capable of evaluating the merits and risks of an investment in the shares of
Escalon Common Stock and of making an informed investment decision with respect
thereto. Radiance understand that Escalon is relying on the truth and accuracy
of the representations, declarations and warranties made in this Section 3 by
Radiance in issuing the shares of Escalon Common Stock without having first
registered the shares under the Securities Act or under the securities laws of
any state or other jurisdiction. Radiance also confirms that (i) it understands
that there are substantial restrictions on the transferability of the shares of
Escalon Common Stock it is to receive pursuant to this Amendment and,
accordingly, it may not be possible for it to liquidate its investment in the
shares of Escalon Common Stock in case of emergency and (ii) it is able to bear
the economic risk of its investment in the shares and to hold the shares for an
indefinite period of time. The shares of Escalon Common Stock are being acquired
by the Radiance in good faith solely for its own account, for investment
purposes only, and are not being acquired with a view to or for the resale,
distribution, subdivision or fractionalization thereof. Radiance does not have
any contract, undertaking, understanding, agreement or arrangement, formal or
informal, with any person to sell, transfer or pledge to any person the shares
of Escalon Common Stock, or any part thereof, and has no current plan to enter
into any such contract, undertaking, agreement or arrangement. Radiance
understands that the legal consequences of the foregoing representations and
warranties are that it must bear the economic risk of its investment in the
shares of the Escalon Common Stock for an indefinite period of time because the
shares have not been registered under the Securities Act.

         4.       Registration Rights.

         (i) Registration Rights. Escalon shall use its best efforts to register
the shares of Escalon Common Stock issued to Radiance in this Amendment within
the seventy-five (75) days following the execution of this Amendment or as soon
as practicable thereafter on Form S-3 under the Securities Act, or any successor
to such form, (or if Escalon is not eligible to use Form S-3, then any other
appropriate form) in a manner that will, upon being declared effective,
constitute a "shelf" registration for purposes of Rule 415 under the Securities
Act, pursuant to which Radiance may sell the shares of Escalon Common Stock
received by it in this Amendment, from time to time and in such amounts as
Radiance may hereafter determine, all in a manner consistent with all applicable
provisions of the Securities Act and the Exchange Act.

         (ii) Registration Procedure. With respect to registration under Section
4(i), Escalon shall prepare and file such amendments, post-effective amendments
and periodic
<PAGE>   3
reports under the Exchange Act as may be necessary to keep such registration
statement continuously effective until the second anniversary of this Amendment.
Notwithstanding the foregoing, Escalon shall not be required to update, pursuant
to this Section 4, any document during a period when Escalon shall, in good
faith and using reasonable business judgment, believe that the premature
disclosure of any event or information would have a material adverse effect on
Escalon or its prospects. Radiance hereby agrees, that upon receipt of notice
from Escalon of the happening of any occurrence described in the preceding
sentence, Radiance shall forthwith discontinue disposition of the shares of
Escalon Common Stock received by it in this Amendment pursuant to such
registration statement until Radiance receipt of the copies of the supplemented
or amended prospectus, and, if so directed by Escalon, Radiance shall deliver to
Escalon all copies in its possession, other than permanent file copies then in
Radiance's possession, of the prospectus covering such Escalon Common Stock
current at the time of receipt of such notice.

         (iii) Expenses. The costs and expenses, other than selling discounts or
commissions, of registration pursuant to this Section 4 shall be paid by Escalon
(including, without limitation, all registration and filing fees, printing
expenses, and costs of special audits incident to or required by such
registration).

          (iv) Indemnification. To the extent permitted by law, Escalon will
indemnify and hold harmless Radiance, any underwriter (as defined in the
Securities Act) for Radiance and each person, if any, who controls Radiance or
underwriter within the meaning of the Securities Act or the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), against any losses, claims,
damages or liabilities (joint or several) to which they may become subject under
the Securities Act, the Exchange Act or other federal or state law, insofar as
such losses, claims, damages or liabilities (or actions in respect thereof)
arise out of or are based upon any of the following statements, omissions or
violations: (i) any untrue statement or alleged untrue statement of a material
fact contained in such registration statement on or after the effective date, or
final prospectus contained therein or any amendments or supplements thereto;
(ii) the omission or alleged omission to state therein a material fact required
to be stated therein, or necessary to make the statements therein not
misleading; or (iii) any violation or alleged violation by Escalon of the
Securities Act, the Exchange Act, any state securities law or any rule or
regulation promulgated under the Securities Act, the Exchange Act or any state
securities law; and the Company will pay to each the Holder, underwriter or
controlling person, as incurred, any legal or other expenses reasonably incurred
by them in connection with investigating or defending any such loss, claim,
damage, liability or action.
<PAGE>   4
         5.       Upon execution of this Amendment Escalon or Buyer shall pay
$17,558 to Radiance in immediately available funds.

         6.       Escalon and Buyer, jointly and severally, shall execute and
deliver to Radiance a term note, in the form attached hereto as Exhibit 1, (the
"Short Term Note") in the amount of $64,884, with interest at the Prime Rate as
published in the Wall Street Journal (New York edition) plus 1%, payable
interest only quarterly beginning on May 31, 2001 and the principal and interest
shall be due in full on January 15, 2002;

         7.       Escalon and Buyer, jointly and severally, shall execute and
deliver to Radiance an additional term note, in the form attached hereto as
Exhibit 2, (the "Long Term Note") in the amount of $717,558, with interest at
the Prime Rate as published in the Wall Street Journal (New York edition) plus
1%, payable interest only quarterly beginning on May 31, 2001 through January
15, 2002 and thereafter principal and interest payable in eleven (11) quarterly
installments beginning on April 15, 2002;

         8.       In the event of a Change of Control (as defined therein) of
either Escalon or Buyer then all obligations under the Short Term Note and the
Long Term Note (collectively, the "Notes") shall be immediately due and payable,
with a prepayment premium as set forth in the Notes.

         9.       Each of Buyer and Escalon, on behalf of itself and each of its
Affiliates, and the predecessors, successors and assigns of each acknowledges
full and complete satisfaction of, and hereby irrevocably, unconditionally,
forever and finally releases and fully discharges Radiance and its Affiliates,
and the shareholders, Affiliates, officers, directors, employees, agents,
attorneys, representatives, predecessors, successors and assigns of each (the
"Radiance Releasees") from, any and all claims, demands, actions, causes of
action, promises, covenants, contracts, agreements, bonds, obligations,
liabilities, losses, damages, costs, expenses and moneys otherwise accrued, due
or unpaid, of whatsoever character, nature or kind, whether in law or in equity,
in contract or in tort, under statute or at common law, whether now known or
unknown, suspected or unsuspected, fixed or contingent, against the Radiance
Releasees arising out of, in connection with, or in any way related to the Asset
Agreement.

         10.      Each of Buyer and Escalon, on behalf of itself and its
Affiliates, having been fully advised by its respective counsel, hereby
expressly and voluntarily waives all rights or benefits that it might otherwise
have under the provisions of Section 1542 of the Civil Code of the State of
California, which provides as follows, and under any and all federal, state,
foreign and/or common-law statutes or principles of similar effect:

         A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT
         KNOW OR SUSPECT TO EXIST IN ITS FAVOR AT THE TIME OF EXECUTING THE
         RELEASE, WHICH IF KNOWN BY IT MUST HAVE MATERIALLY AFFECTED ITS
         SETTLEMENT WITH DEBTOR.

         11.      Each of Buyer and Escalon, on behalf of itself and its
Affiliates, represents and acknowledges that (a) the terms of this Amendment
have been completely read and fully understood and accepted for the purpose of
effecting a full, complete and final compromise,
<PAGE>   5
adjustment, and settlement of the matters referred to herein; (b) it intends to
be fully bound hereby and may not hereafter raise any claim of mistake of fact,
misunderstanding, or inadequacy of consideration in connection herewith; and (c)
in executing this Agreement, it relies solely upon its own judgment, belief, and
knowledge, and the advice and recommendations of its own independently selected
counsel, concerning the nature, extent, and duration of its rights and claims,
and it has not been influenced to any extent whatsoever in executing the same by
any representation or statement made or omitted to be made by the other parties
hereto or by any person representing another party.

         12.      This Amendment shall be governed by the terms in the Asset
Agreement, provided however that in the event of any conflict or variance
between the terms of this Amendment and the Asset Agreement, this Amendment
shall control.

         13.      The parties acknowledge and agree that all of the terms,
provisions, covenants and conditions of the Asset Agreement shall hereafter
continue in full force and effect in accordance with the terms thereof, except
to the extent amended, modified, deleted or revised in this Amendment.

         14.      This Amendment may be executed in any number of counterparts
by facsimile or otherwise, each of which shall be deemed an original, but which
together shall constitute one and the same instrument.

         IN WITNESS WHEREOF, this Amendment has been executed by the parties
hereto as of the day and year first written above.

                                    RADIANCE MEDICAL SYSTEMS, INC.

                                    By:  /s/ Stephen R. Kull
                                        ----------------------------------------
                                    Title: VP Finance and Adm.
                                          --------------------------------------

                                    ESCALON MEDICAL CORP.

                                    By: /s/ Richard J. DePiano, CEO
                                        ----------------------------------------
                                    Richard J. DePiano, CEO
                                    --------------------------------------------

                                    ESCALON VASCULAR ACCESS, INC.

                                    By: /s/ Richard J. DePiano, CEO
                                       -----------------------------------------
                                    Richard J. DePiano, CEO
                                    --------------------------------------------

     [SIGNATURE PAGE TO THE AMENDMENT TO ASSETS SALE AND PURCHASE AGREEMENT
            ESCALON MEDICAL CORP. AND RADIANCE MEDICAL SYSTEMS, INC.]

<PAGE>   6
                                                              ESMC Final 3/15/01

                                    EXHIBIT 1

                                 SHORT TERM NOTE

                                                    February 28, 2001

$64,884.00

         FOR VALUE RECEIVED, Escalon Medical Corp, a Delaware corporation, and
Escalon Vascular Access, Inc., a Delaware corporation, both having an address at
351 East Conestoga Road, Wayne, PA 19087 (each a "Maker"), hereby, jointly and
severally, covenant and promise to pay to Radiance Medical Systems, Inc., a
Delaware corporation, having an address at 13700 Alton Parkway, Suite 160,
Irvine, CA 92618 ("Payee"), at Payee's address first above written or at such
other address as Payee may designate in writing, Sixty Four Thousand Eight
Hundred Eighty Four Dollars ($64,884.00), lawful money of the United States of
America, together with interest thereon computed from the date hereof at a rate
per annum equal to 1 percentage point above the prime rate as published in the
Wall Street Journal (New York Edition) on the last business day of each quarter
(to be applicable to the succeeding quarter), which only interest shall be
payable in quarterly installments commencing on the 31st day of May, 2001, and
on the 31st day of August and the 30th day of November, until January 15, 2002,
on which date all outstanding principal and interest shall be due and payable.
To the extent any payment of principal or interest is not paid when due, it
shall accrue interest until paid at the rate of one and one-half percent
(1-1/2%) per month, or the maximum rate permitted by law, which is less.

EACH MAKER JOINTLY AND SEVERALLY COVENANTS AND AGREES WITH PAYEE AS FOLLOWS:

         1.       Maker will pay the indebtedness evidenced by this Note as
provided herein.

         2.       Maker shall not have the right to prepay the indebtedness
evidenced by this Note, in whole or in part, unless Maker shall give Payee ten
(10) days notice of its intention to prepay such indebtedness and shall pay to
Payee on the date of the prepayment all interest accrued to said date and a
prepayment premium. The prepayment premium shall be calculated by multiplying
the remaining principal balance times the excess, if any of the rate of return
achieved by Payee on cash or cash equivalents owned by Payee for the most recent
quarter prior to the date of prepayment over the Prime Rate plus 1% on the date
of prepayment, divided by twelve (12) months, multiplied by the number of
remaining months to maturity (see attached example on Exhibit A) The Prime Rate
shall be defined as the published Prime Rate in the Wall Street Journal (New
York edition) on the date of prepayment.

         3.       If any of the following events shall occur:
<PAGE>   7
                  (1)      the Maker defaults in the payment of any principal or
interest due under this Note or the Long Term Note issued in conjunction with
this Note under the Amendment and Supplement Agreement and Release, dated as of
February 28, 2001, by and among Payee and each Maker, (together with this Note,
the "Notes");

                  (2)      any material default by either Maker of any other
material obligation under the Notes or the Assets Sale and Purchase Agreement,
dated January 21, 1999, by and among Payee and each Maker, as amended;

                  (3)      there shall be a Change in Control of either Maker.

then, and in each and every such case, the Payee shall provide notice to either
or both Makers and provide Makers ten (10) days to begin to cure such default.
Thereafter, if Makers shall not have cured such default, Payee may by written
notice to either or both Makers declare all amounts under this Note to be
forthwith due and payable and thereupon the balance shall become so due and
payable, along with a prepayment premium as calculated in Section 2 above,
without presentation, protest or further demand or notice of any kind, all of
which are hereby expressly waived.

         4.       For purposes hereof a Change in Control of Escalon Vascular
Access, Inc., shall be deemed to have occurred if Escalon Vascular Access, Inc.
is no longer a wholly owned subsidiary of Escalon Medical Corp. For purposes
hereof a Change of Control of Escalon Medical Corp. shall be deemed to have
occurred only (i) if Escalon Medical Corp. is liquidated or dissolved, (ii) if
Escalon Medical Corp. sells substantially all of its assets or (iii) if Escalon
Medical Corp is acquired by another entity.

         5.       Maker hereby waives presentment for payment, demand, protest,
and notice of dishonor. If an action is brought for collection under this Note,
the Payee shall be entitled to receive all costs of collection, including,
without limitation, its reasonable attorneys' fees.

         6.       Any notice or demand required or permitted to be made or given
hereunder shall be deemed sufficiently made and given if given by the mailing of
such notice or demand by certified or registered mail, return receipt requested,
with postage prepaid, addressed, if to either Maker, at such Maker's address
first above written, or if to Payee, at Payee's address first above written. Any
party may change its address by like notice to the other party.

         7.       This Note may not be changed or terminated orally, but only by
an agreement in writing signed by the party against whom enforcement of any
change, modification, termination, waiver, or discharge is sought. This Note
shall be construed and enforced in accordance with the laws of Delaware.
<PAGE>   8
         IN WITNESS WHEREOF, Maker has executed this Note as of the date first
above written.

                                    ESCALON MEDICAL CORP
ATTEST:

                                    By:
                                        ----------------------------------------
                                             Richard J. DePiano, CEO
By
   ------------------------
         Secretary

                                    ESCALON VASCULAR ACCESS, INC.

                                    By:
                                        ----------------------------------------
                                             Richard J. DePiano, CEO

                       [SIGNATURE PAGE TO SHORT TERM NOTE]
<PAGE>   9
                                    Exhibit A

                      See Exhibit 3 of Amendment Agreement
<PAGE>   10
COMMONWEALTH OF PENNSYLVANIA, COUNTY OF                     , ss.

         On this ___ day of February, 2001, before me, the undersigned officer,
personally appeared ____ , to me known, who being duly sworn, did depose and say
and did acknowledge that he is the CEO of Escalon Medical Corp, the corporation
described in and which executed the foregoing Note; that he knows the seal of
said corporation; that the seal affixed to said Note is such corporate seal;
that it was so affixed by the order of the board of directors of the said
corporation; and that he signed his name thereto by like order for the uses and
purposes therein contained.

         IN WITNESS WHEREOF I hereunto set my hand and official seal.

                                             -------------------------------
                                                      Notary Public
                                                My commission expires on
<PAGE>   11
                                                                       Exhibit 3

<TABLE>
<CAPTION>
Payment #      Date        Payment of Principal     Balance
<S>          <C>           <C>                    <C>
              2/28/01                              717,558
       1      4/15/02                   65,233     652,325
       2      7/15/02                   65,233     587,092
       3     10/15/02                   65,233     521,859
       4      1/15/03                   65,233     456,626
       5      4/15/03                   65,233     391,393
*      6      7/15/03                   65,233     326,160
       7     10/15/03                   65,233     260,927
       8      1/15/04                   65,233     195,694
       9      7/15/04                   65,233     130,461
      10     10/15/04                   65,233      65,228
      11      1/15/05                   65,228           0
</TABLE>

Assumptions

*  Sale of Company 7/16/2003, Prime Rate 8 1/2%, Radiance Earn Rate 5 1/2%

Formula
Remaing Outstanding Principal X  [Prime Rate + 1% -
(Radiance Earn Rate)] / 12 X Remaining Months to Maturity   = Prepayment Premium
326,160 X  [(8 1/2 % + 1 %) / 12] X 15 = 16,308
<PAGE>   12
                                                              ESMC Final 3/15/01

                                   EXHIBIT 2

                                 LONG TERM NOTE

                                                               February 28, 2001

$717,558.00

     FOR VALUE RECEIVED, Escalon Medical Corp., a Delaware corporation, and
Escalon Vascular Access, Inc., a Delaware corporation, both having an address at
351 East Conestoga Road, Wayne, PA 19087 (each a "Maker"), hereby, jointly and
severally, covenant and promise to pay to Radiance Medical Systems, Inc., a
Delaware corporation, having an address at 13700 Alton Parkway, Suite 160,
Irvine, CA 92618 ("Payee"), at Payee's address first above written or at such
other address as Payee may designate in writing, Seven Hundred and Seventeen
Thousand Five Hundred and Fifty Eight Dollars ($717,558.00), lawful money of the
United States of America, together with interest thereon computed from the date
hereof at a rate per annum equal to 1 percentage point above the prime rate as
published in the Wall Street Journal (New York Edition) on the last business day
of each quarter (to be applicable to the succeeding quarter), which only
interest shall be payable in quarterly installments commencing on the 31st day
of May, 2001, and continuing on the 31st day of August, the 30th day of November
and the 28th day of February. Thereafter, beginning on the 15th day of April,
2002 Maker shall pay principal and interest in eleven (11) quarterly
installments. To the extent any payment of principal or interest is not paid
when due, it shall accrue interest until paid at the rate of one and one-half
percent (1 1/2%) per month, or the maximum rate permitted by law, which is less.

EACH MAKER JOINTLY AND SEVERALLY COVENANTS AND AGREES WITH PAYEE AS FOLLOWS:

     1.   Maker will pay the indebtedness evidenced by this Note as provided
herein.

     2.   Maker shall not have the right to prepay the indebtedness evidenced
by this Note, in whole or in part, unless Maker shall give Payee ten (10) days
notice of its intention to prepay such indebtedness and shall pay to Payee on
the date of the prepayment all interest accrued to said date and a prepayment
premium. The prepayment premium shall be calculated by multiplying the
remaining principal balance times the excess, if any of the rate of return
achieved by Payee on cash or cash equivalents owned by Payee for the most
recent quarter prior to the date of prepayment over the Prime Rate plus 1% on
the date of prepayment, divided by twelve (12) months, multiplied by the number
of remaining months to maturity (see attached example on Exhibit A). The Prime
Rate shall be defined as the published Prime Rate in the Wall Street Journal
(New York edition) on the date of prepayment.

<PAGE>   13

     3.   If any of the following events shall occur:

          (1)  the Maker defaults in the payment of any principal or interest
due under this Note or the Long Term Note issued in conjunction with this Note
under the Amendment and Supplement Agreement and Release, dated as of February
28, 2001, by and among Payee and each Maker, (together with this Note, the
"Notes");

          (2)  any material default by either Maker of any other material
obligation under the Notes or the Assets Sale and Purchase Agreement, dated
January 21, 1999, by and among Payee and each Maker, as amended;

          (3)  there shall be a Change in Control of either Maker.

then, and in each and every such case, the Payee shall provide notice to either
or both Makers and provide Makers ten (10) days to begin to cure such default.
Thereafter, if Makers shall not have cured such default, Payee may by written
notice to either or both Makers declare all amounts under this Note to be
forthwith due and payable and thereupon the balance shall become so due and
payable, along with a prepayment premium as calculated in Section 2 above,
without presentation, protest or further demand or notice of any kind, all of
which are hereby expressly waived.

     4.   For purposes hereof a Change in Control of Escalon Vascular Access,
Inc., shall be deemed to have occurred if Escalon Vascular Access, Inc. is no
longer a wholly owned subsidiary of Escalon Medical Corp. For purposes hereof a
Change of Control of Escalon Medical Corp. shall be deemed to have occurred
only (i) if Escalon Medical Corp. is liquidated or dissolved, (ii) if Escalon
Medical Corp. sells substantially all of its assets or (iii) if Escalon Medical
Corp. is acquired by another entity.

     5.   Maker hereby waives presentment for payment, demand, protest, and
notice of dishonor. If an action is brought for collection under this Note, the
Payee shall be entitled to receive all costs of collection, including, without
limitation, its reasonable attorneys' fees.

     6.   Any notice or demand required or permitted to be made or given
hereunder shall be deemed sufficiently made and given if given by the mailing
of such notice or demand by certified or registered mail, return receipt
requested, with postage prepaid, addressed, if to either Maker, at such Maker's
address first above written, or if to Payee, at Payee's address first above
written. Any party may change its address by like notice to the other party.

     7.   This Note may not be changed or terminated orally, but only by an
agreement in writing signed by the party against whom enforcement of any
change, modification, termination, waiver, or discharge is sought. This Note
shall be construed and enforced in accordance with the laws of Delaware.
<PAGE>   14
  IN WITNESS WHEREOF, Maker has executed this Note as of the date first above
written.

                                   ESCALON MEDICAL CORP
ATTEST:
                                   By:
                                       --------------------------
                                        Richard J. DePiano, CEO
By
   -------------------
     Secretary
                                   ESCALON VASCULAR ACCESS, INC.

                                   By:
                                       --------------------------
                                        Richard J. DePiano, CEO

                       [SIGNATURE PAGE TO LONG TERM NOTE]
<PAGE>   15
                                   Exhibit A
                      See Exhibit 3 of Amendment Agreement
<PAGE>   16
COMMONWEALTH OF PENNSYLVANIA, COUNTY OF              , ss.

     On this    day of February, 2001, before me, the undersigned officer,
personally appeared                                           , to me known, who
being duly sworn, did depose and say and did acknowledge that he is the CEO of
Escalon Medical Corp, the corporation described in and which executed the
foregoing Note; that he knows the seal of said corporation; that the seal
affixed to said Note is such corporate seal; that it was so affixed by the order
of the board of directors of the said corporation; and that he signed his name
thereto by like order for the uses and purposes therein contained.

          IN WITNESS WHEREOF I hereunto set my hand and official seal.

                              ----------------------------
                              Notary Public
                              My commission expires on<PAGE>   1
EXHIBIT 4.1

                       UPDATED SCHEDULE TO EXHIBIT 4.9 TO
                       REGISTRATION STATEMENT ON FORM S-1
                        (No. 333-37833) FILED PURSUANT TO
                 INSTRUCTION 2 TO ITEM 601(A) OF REGULATION S-K

                              CAPITAL STOCK WARRANT
<TABLE>
<CAPTION>
                                              Purchase        Exercise
Holder          Shares         Date/Term      Price           Schedule
------          ------         ---------      -----------     ---------
<S>             <C>            <C>            <C>             <C>
Susan
McBroom         10,000         10/1/96;       $2.50/share
                               5 years

George
Strong          35,000         10/1/96;       $2.50/share     3/26/97-
                               10 years                       35,000
                                                              warrants

Roger
Breed           21,972         10/1/96;       $2.50/share     4/1/97 -
                               5 years                        21,972
                                                              warrants

Susan
McBroom         7,500          2/24/98;       $6.94/share
                               5 years
</TABLE>

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00030-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00030-of-00352.parquet"}]]