Document:

<PAGE>

                                                                   EXHIBIT 10.37

             CONFIDENTIAL TREATMENT REQUESTED. CONFIDENTIAL PORTIONS
     OF THIS DOCUMENT MARKED [****] HAVE BEEN REDACTED AND HAVE BEEN FILED
                SEPARATELY WITH THE U.S. SECURITIES AND EXCHANGE
                                   COMMISSION.

                          TRANSITION SERVICES AGREEMENT

                                 BY AND BETWEEN

                            IPR PHARMACEUTICALS, INC.

                                       AND

                               ATHEROGENICS, INC.

                             DATE: DECEMBER 22, 2005

<PAGE>

TABLE OF CONTENTS

<TABLE>
<S>                                                                     <C>
1      Definitions.................................................      1
2      Construction................................................      6
3      Amendment...................................................      6
4      Transition Assistance.......................................      6
5      Fees........................................................      8
6      Invoicing, Payment, Recordkeeping and Audits................     11
7      Representations and Warranties..............................     12
8      Indemnification.............................................     13
9      Force Majeure...............................................     17
10     Term and Termination........................................     17
11     Confidentiality.............................................     19
12     Use of Name.................................................     21
13     Notices.....................................................     21
14     Relationship of the Parties.................................     22
15     Rights Of Third Parties.....................................     23
16     Assignment..................................................     23
17     Entire Agreement............................................     23
18     Expenses....................................................     23
19     Waiver and Non-Exclusion of Remedies........................     24
20     Severability................................................     24
21     Governing Law and Disputes..................................     24
22     Equitable Relief............................................     24
23     Environmental Provisions....................................     25
24     Counterparts................................................     25
</TABLE>

EXHIBITS

Exhibit 1 -- Process Improvements
Exhibit 2 -- Estimated Spray Drying Capital Expenditure
Exhibit 3 -- Estimated Manufacturing Start-Up and Other Costs
Exhibit 4 -- Existing Agreements
Exhibit 5 -- Dow Consent to Assignment

                                       (i)
<PAGE>

                          TRANSITION SERVICES AGREEMENT

      This Transition Services Agreement (the "AGREEMENT") is made as of
December 22, 2005 and shall be effective as of the Effective Date (as defined
herein) by and between

(1)   IPR Pharmaceuticals, Inc., a company organized and existing under the laws
      of Puerto Rico with an address at CARR 188 LOTE 17 SAN ISIDRO INDUSTRIAL
      PARK, CANOVANAS, PR 00729 ("ASTRAZENECA"); and

(2)   AtheroGenics, Inc., a Georgia corporation with principal executive offices
      at 8995 Westside Parkway, Alpharetta, Georgia 30004 (the "AGIX").

RECITALS

(A)   WHEREAS, AstraZeneca desires to receive certain transition services from
      AGIX to facilitate AstraZeneca's exercise of the manufacturing rights
      granted pursuant to the License Agreement; and

(B)   WHEREAS, AGIX is willing to provide such transition services on the terms
      and conditions set forth herein.

AGREEMENT

NOW, THEREFORE, in consideration of the mutual covenants contained in this
Agreement, and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties, intending to be
legally bound, agree as follows:

1     DEFINITIONS

Unless otherwise specifically provided in this Agreement, the following terms
shall have the following meanings:

1.1   "AFFILIATE" means any Person that directly (or indirectly through one or
      more intermediaries) controls, is controlled by, or is under common
      control with a Party. For purposes of this definition only, the terms
      "controls," "controlled," and "control" means (i) the direct or indirect
      ability or power to direct or cause the direction of the management and
      policies of an entity or otherwise direct the affairs of such entity,
      whether through ownership of equity, voting securities, or beneficial
      interest, by contract, or otherwise, or (ii) the ownership, directly or
      indirectly, of at least 50% of the voting securities (or other comparable
      ownership interest for an entity other than a corporation) of a Party.

1.2   "AGIX INDEMNITEES" has the meaning set forth in Section 8.2.

                                       1
<PAGE>

1.3   "AGIX INFORMATION" means all data and information related to or comprised
      in Intellectual Property Rights and Know-How, as well as other information
      in relation to AGIX's general business operations, SDD, a SDD
      Manufacturing Process, the Final Commercial Products, a Manufacturing
      Process, an SDD Process Improvement, or a Process Improvement, which is
      owned by AGIX.

1.4   "APPLICABLE LAWS AND REGULATIONS" mean all applicable statutes,
      ordinances, regulations, rules, or orders of any kind whatsoever of any
      Governmental Authority, including, without limitation, the Food, Drug and
      Cosmetic Act, Prescription Drug Marketing Act, Generic Drug Enforcement
      Act of 1992 (21 U.S.C. Section 335a et seq.), and Anti-Kickback Statute
      (42 U.S.C. Section 1320a-7b et seq.), all as amended from time to time.

1.5   "ASTRAZENECA INFORMATION" means all data and information related to or
      comprised in Intellectual Property Rights and Know-How, as well as other
      information in relation to AstraZeneca's general business operations, SDD,
      a SDD Manufacturing Process, the Final Commercial Products, a
      Manufacturing Process, or a Process Improvement, which data and
      information is owned by AstraZeneca.

1.6   "CAPACITY RESERVE FEE" shall have the meaning set forth in the Dow
      Agreement.

1.7   "COMBINATION PRODUCT" means a Product in final form that includes one or
      more pharmaceutically active ingredients other than the Compound, in
      combination with the Compound, that are sold as a fixed dose or separate
      doses in a single package and priced as one item. All references to
      Product in this Agreement shall be deemed to include Combination
      Product(s).

1.8   "COMPOUND" means AGI-1067, which is chemically defined as [****],
      including its pharmacologically acceptable salts, solvates, hydrates,
      hemihydrates, polymorphs, metabolites, free base forms, pro-drugs, esters,
      tautomers, and if applicable, any isomers, stereoisomers, racemates,
      enantiomers and all optically active forms thereof.

1.9   "CONFIDENTIAL INFORMATION" has the meaning set forth in Section 11.1.1
      hereof.

1.10  "CONTROL" or "CONTROLLED" means with respect to any Intellectual Property
      Right, that the Party owns or has a license to such Intellectual Property
      Right or Information and has the ability to grant access, a license, or a
      sublicense to such Intellectual Property Right to the other Party as
      provided for in this Agreement without violating an agreement with, or
      infringing any rights of, a Third Person as of the time such person would
      be first required under this Agreement to grant the other person such
      access, license or sublicense.

1.11  "DISCLOSING PARTY" means the Party disclosing Confidential Information.

1.12  "DOW AGREEMENT" means that "Commercial Supply Agreement for Production of
      AGI-1067 and Probucol between The Dow Chemical Company ("DOW") and

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                       2
<PAGE>

      AtheroGenics, Inc." dated as of October 6, 2005, excluding any amendments
      thereto entered into after the Effective Date.

1.13  "EFFECTIVE DATE" means the Effective Date of the License Agreement.

1.14  "EXISTING AGREEMENTS" means the Dow Agreement and the other agreements set
      forth on Exhibit 4.

1.15  "FDA" means the United States Food and Drug Administration, or any
      successor federal agency having responsibility over United States
      Regulatory Approvals.

1.16  "FINAL COMMERCIAL PRODUCT" means a pharmaceutical product in
      ready-for-sale form, packaged and labeled dosage form marketed by or on
      behalf of AstraZeneca, its Affiliates or Sublicensees, now or in the
      future, that comprises or utilizes SDD or the Compound in its manufacture.

1.17  "FORCE MAJEURE" has the meaning set forth in Section 9.1.

1.18  "GOVERNMENTAL AUTHORITY" means any court, tribunal, arbitrator, agency,
      commission, official or other instrumentality of any federal, state, or
      other political subdivision, or supranational body, domestic or foreign.

1.19  "INDIRECT TAXES" means value added taxes, sales taxes, consumption taxes
      and other similar taxes.

1.20  "INFORMATION" means any information Controlled by either Party, including,
      but not limited to: (a) any and all inventions (whether or not
      patentable), Know-How, developments, materials, data, analyses, and the
      like, regardless of whether the information is stored or transmitted in
      oral, documentary, or electronic form; (b) information relating to
      research and development plans, experiments, results, compounds,
      therapeutic leads, candidates and products, clinical and preclinical data,
      trade secrets and manufacturing, marketing, financial, regulatory,
      personnel and other business information and plans, and all scientific,
      clinical, regulatory, marketing, financial and commercial information or
      data; (c) AstraZeneca Information; and (d) AGIX Information.

1.21  "INTELLECTUAL PROPERTY RIGHTS" means trade secrets, patent rights,
      trademarks, service marks, trade names, design rights, copyrights
      (including rights in computer software) and any rights or property similar
      to any of the foregoing in any part of the world, whether registered or
      not, together with the right to apply for the registration of any such
      rights, and all rights or forms of protection having equivalent or similar
      effect, in any part of the world.

1.22  "INVOICE CURRENCY" means United States dollars.

1.23  "KNOW-HOW" means all technical information or data relating to SDD,
      whether protected by Intellectual Property Rights or not, including, but
      not limited to technology, processes, specifications, formulas,
      procedures, techniques, SHE

                                       3
<PAGE>

      Information, practices and instructions of, and scientific, analytical and
      technical data regarding the synthesis, manufacturing and pharmaceutical
      processing of SDD or the Compound.

1.24  "LICENSE AGREEMENT" means the License and Collaboration Agreement between
      AstraZeneca and AGIX, dated as of December 22, 2005, as the same shall be
      amended from time to time.

1.25  "LOSSES" means any and all liabilities, claims, demands, causes of action,
      damages, loss and expenses incurred directly in connection with this
      Agreement, including interest, penalties, and reasonable lawyers' fees and
      disbursements.

1.26  "MANUFACTURING PROCESS" means any process (or any step in or portion of
      any process) used or developed by AGIX, Third Party Suppliers, or
      AstraZeneca (or any of their Affiliates) as of the Effective Date or at
      any time thereafter, in manufacturing SDD or Final Commercial Product.

1.27  "MANUFACTURING START-UP AND OTHER COSTS" shall mean such expenditures
      estimated by AGIX as all reasonably necessary expenditures for the start
      up and launch of manufacture of SDD (other than those expenditures
      described as Spray Dried Capital Expenditures) as set forth in Exhibit 3.

1.28  "PARTIES" means AstraZeneca and AGIX and "PARTY" means either AstraZeneca
      or AGIX.

1.29  "PERSON" means a natural person, a corporation, a partnership, a trust, a
      joint venture, a limited liability company, any Governmental Authority or
      any other entity or organization.

1.30  "PROCESS IMPROVEMENT" has the meaning set forth in Section 5.3.1.

1.31  "PRODUCT" means a pharmaceutical product that contains or incorporates the
      Compound, whether in development or approved by any Regulatory Authority,
      including all formulations, line extensions and modes of administration
      (including, without limitation, all delivery devices, dosage forms or
      other peripherals and consumables), including, without limitation,
      Combination Products.

1.32  "RECEIVING PARTY" means the Party to whom Confidential Information is
      disclosed.

1.33  "REGULATORY APPROVAL" means any and all approvals (including pricing
      approvals to the extent necessary), licenses, registrations or
      authorizations of any Regulatory Authority, necessary for the development,
      manufacture and commercialization of a Final Commercial Product.

1.34  "REGULATORY AUTHORITY" means, in a particular country or jurisdiction, any
      applicable government regulatory authorities involved in granting
      Regulatory

                                       4
<PAGE>

      Approval and/or, to the extent required in such country or jurisdiction,
      pricing approval of Final Commercial Product in such country or
      jurisdiction, including without limitation, (a) in the United States, the
      FDA, and any other applicable governmental or regulatory authority in the
      United States having jurisdiction over Final Commercial Product, and any
      successor government authority having substantially the same function, and
      (b) any foreign equivalent thereof.

1.35  "SAVINGS" has the meaning set forth in Sections 5.3.5 and 5.3.6,
      respectively.

1.36  "SAVINGS TRIGGER DATE" has the meaning set forth in Section 5.3.3.

1.37  "SHE INFORMATION" means to the extent applicable and available, and as
      agreed to by the Parties, safety, health and environmental information as
      it relates to SDD and SDD Manufacturing Process including, without
      limitation: safety data sheets, chemical hazard assessments, operational
      hazard test results and environmental assessments.

1.38  "SPRAY DRIED DISPERSION" or "SDD" means the Compound in spray-dried form.

1.39  "SDD MANUFACTURING PROCESS" means any process (or any step in or portion
      of any process) used or developed by a Party (or any of its Affiliates or
      Third Party Suppliers) as of the Effective Date or at any time thereafter,
      in manufacturing SDD.

1.40  "SPRAY DRYING CAPITAL EXPENDITURE" shall mean such capital expenditures
      estimated by AGIX as being all reasonably necessary capital expenditures
      relating directly to the spray drying process to manufacture SDD, which
      expenditures are estimated in Exhibit 2.

1.41  "SUBLICENSEE" means any Third Person (including, without limitation, a
      distributor) to which AstraZeneca or any of its Affiliates grants any
      right to make, use, market, or import and sell a Final Commercial Product
      in accordance with the License Agreement. A Third Person who is granted
      only the right to distribute or promote a Final Commercial Product (such
      as a contract sales organization) shall not be considered a Sublicensee.

1.42  "TERM" means the period beginning on the Effective Date and continuing
      until the date upon which this Agreement is terminated in accordance with
      Article 10.

1.43  "THIRD PARTY" or "THIRD PERSON" means any Person other than AGIX or
      AstraZeneca and their respective Affiliates.

1.44  "THIRD PARTY SUPPLIER" means a Person engaged by a Party, including,
      without limitation, Dow, for the supply of SDD or any aspect of the
      supply, manufacture or warehousing of SDD, its constituents or raw
      materials (such as Probucol), including the performance of a SDD
      Manufacturing Process.

                                       5
<PAGE>

1.45  "TRANSITION PERIOD" means the period commencing on the Effective Date and
      continuing until the receipt of the first Regulatory Approval for the
      Product.

2     CONSTRUCTION

2.1   Except where the context requires otherwise, whenever used the singular
      includes the plural, the plural includes the singular, the use of any
      gender is applicable to all genders and the word "or" has the inclusive
      meaning represented by the phrase "and/or." Whenever this Agreement refers
      to a number of days, unless otherwise specified, such number refers to
      calendar days. The headings of this Agreement are for convenience of
      reference only and do not define, describe, extend or limit the scope or
      intent of this Agreement or the scope or intent of any provision contained
      in this Agreement. The term "including" or "includes" as used in this
      Agreement means including, without limiting the generality of any
      description preceding such term. The wording of this Agreement shall be
      deemed to be the wording mutually chosen by the Parties and no rule of
      strict construction shall be applied against any Party.

2.2   References to Articles, Sections, Exhibits and Schedules refer to the
      Articles, Sections, Exhibits and Schedules of and to this Agreement.

2.3   The Exhibits and the Schedules (as amended from time to time by agreement
      of the Parties in writing) form part of this Agreement and have the same
      force and effect as if expressly set out in the body of the Agreement. Any
      reference to the Agreement includes the Exhibits and the Schedules. Any
      breach of the Exhibits or Schedules shall be deemed as a breach of this
      Agreement.

3     AMENDMENT

      Any amendment or modification of this Agreement (including any amendment
      of any Exhibit or Schedule hereto) must be in writing and signed by
      authorized representatives of both Parties.

4     TRANSITION ASSISTANCE

4.1   Transition Assistance. Following the Effective Date and continuing
      throughout the Transition Period, AGIX shall cooperate with AstraZeneca
      and provide AstraZeneca with all reasonable assistance as reasonably
      requested by AstraZeneca to facilitate manufacturing of the Final
      Commercial Product and Compound, including, without limitation, assistance
      regarding the Process Improvements. Such technical assistance shall
      include, without limitation, (i) transitioning to AstraZeneca
      relationships with Third Party Suppliers, vendors and contractors relating
      to the manufacture of raw materials, Compound and Spray Dried Dispersion
      and (ii) transferring to AstraZeneca financial, business, regulatory,
      technical and all other necessary or useful information relating to the
      manufacture and supply of raw materials, Compound and Spray Dried
      Dispersion.

4.2   Manufacturing Timelines. [****]

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                       6
<PAGE>

4.3   Assignment of Contracts and Other Rights. AGIX shall use commercially
      reasonable efforts to assign to AstraZeneca and, upon such assignment,
      AstraZeneca shall assume all rights and obligations of AGIX under the Dow
      Agreement and the other Existing Agreements, provided, however that
      AstraZeneca will, at AGIX's option, use commercially reasonable efforts to
      assign to AGIX such agreements, to the extent then still in effect, and
      any new agreements entered into by AstraZeneca relating to the manufacture
      of raw materials, Compound and Spray Dried Dispersion together with any
      equipment funded under Section 5.2 and used in connection with the
      manufacture thereof, and the right to the use thereof in the event that
      AstraZeneca terminates the License Agreement pursuant to Sections 13.3(a),
      13.3(b), 13.3(c) or 13.3(d) of the License Agreement or AGIX terminates
      the License Agreement pursuant to Section 13.4 thereof, provided, however,
      that in the event that AGIX elects to have an agreement, equipment or the
      use thereof assigned to AGIX pursuant to this Section 4.3, AstraZeneca
      shall be relieved of its obligation pursuant to Section 13.5(b)(vi) of the
      License Agreement to supply Products and/or Compounds to AGIX. AGIX and
      AstraZeneca shall use commercially reasonable efforts to obtain any third
      party consents that may be necessary to effect the assignments required by
      this Section 4.3. Immediately following the execution of this Agreement,
      AGIX shall contact Niro to obtain Niro's consent to the assignment of
      PO#B24579 set forth on Exhibit 4 to AstraZeneca. In the event AGIX is
      unable to obtain Niro's consent, AGIX shall lease or, at AstraZeneca's
      option, assign the equipment purchased thereunder to AstraZeneca, for no
      addition consideration beyond that set forth herein, and shall pass
      through to AstraZeneca all warranties set forth in such purchase order.

4.4   Assistance Following Transition Period. Following the Transition Period,
      AGIX shall continue to provide such reasonable additional technical and
      regulatory assistance as reasonably requested by AstraZeneca, at
      AstraZeneca's expense. Such assistance may be provided by telephone, video
      conference or in-person at AstraZeneca's facility or at any third party's
      facility, as mutually agreed; provided that, the Parties reasonably agree
      to the scheduling of any such assistance.

4.5   Certain Additional Covenants. Following the date hereof, AGIX (i) will not
      enter into any contracts related to the manufacture or supply of Spray
      Dried Dispersion without the prior written consent of AstraZeneca, except
      that AGIX may take any of the foregoing actions in the ordinary course
      prior to the Effective Date without AstraZeneca's consent; (ii) will not
      terminate, take any action likely to result in a breach of or prepay any
      contract or obligation related to the manufacture or supply of Spray Dried
      Dispersion without the prior written consent of AstraZeneca; and (iii)
      will cause each of its Affiliates to comply with this Section 4.5.

4.6   Meetings. During the Transition Period, AstraZeneca shall notify AGIX
      promptly of any material developments with respect to, and shall keep AGIX
      informed on an ongoing basis regarding, the manufacture and supply of the
      SDD, the Compound and materials, and regulatory matters. During the
      Transition Period,

                                       7
<PAGE>

      the Parties shall meet no less than monthly regarding the manufacturing,
      supply and regulatory filings related to the SDD, the Compound and
      materials.

5     FEES

5.1   Costs of Transitional Assistance. AstraZeneca shall reimburse AGIX for all
      costs and expenses reasonably incurred by AGIX in providing transition
      assistance hereunder. Promptly following the Effective Date, the Parties
      will agree on a process and rates for determining such costs and expenses.

5.2   Reimbursement for Capital and Other Expenses.

      5.2.1 AstraZeneca shall reimburse AGIX for [****] of the capital and other
            expenses set forth on Exhibits 2 and 3 incurred by AGIX prior to the
            Effective Date.

      5.2.2 After the Effective Date, AGIX shall reimburse AstraZeneca for
            [****] of the capital and other expenses set forth on Exhibits 2 and
            3 incurred by AstraZeneca, up to the maximum AGIX payment levels
            specified on such Exhibits.

      5.2.3 AstraZeneca shall pay to AGIX, within thirty (30) days following the
            last date that AstraZeneca is no longer entitled to elect to
            terminate the License Agreement pursuant to Sections 13.3(a),
            13.3(b) or 13.3(c) (and has not exercised any such election to
            terminate the License Agreement), or prior to such last date, AGIX
            terminates the License Agreement pursuant to Section 13.4 thereof,
            an amount equal to (a) the capital and other expenses set forth on
            Exhibits 2 and 3 incurred by AGIX prior to the Effective Date and
            not previously reimbursed by AstraZeneca pursuant to Section 5.2.1
            plus (b) any amounts paid by AGIX pursuant to Section 5.2.2 above.

      5.2.4 All amounts payable pursuant to this Section 5.2 shall be made
            within thirty (30) days after receipt of an invoice therefor,
            accompanied by evidence of payment of such expenses.

5.3   Process Improvements.

      5.3.1 As of the Effective Date, AGIX has proposed the following
            improvements to the manufacturing process, as more fully described
            in Exhibit 1 (the "PROCESS IMPROVEMENTS"):

            (a) [****] (Part A, Exhibit 1);

            (b) [****] (Part B, Exhibit 1);

            (c) [****] (Part C, Exhibit 1); and

            (d) [****] (Part D, Exhibit 1).

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                       8
<PAGE>

      5.3.2 AstraZeneca shall have the right to determine which of the Process
            Improvements to implement and shall pay all costs associated with
            implementing any such Process Improvements. The Process Improvements
            described in Sections 5.3.1(a)-(c) shall be considered to have been
            implemented on the date that the price paid by AstraZeneca to any
            Third Party Supplier for SDD or the Compound is reduced to reflect
            such implementation (the "PROCESS IMPLEMENTATION DATE").

      5.3.3 AGIX shall not be entitled to receive Savings, if any, from any
            Process Improvement until the earlier of: (a) the date on which
            [****] of the Final Commercial Product sold by AstraZeneca, its
            Affiliates and Sublicensees in two consecutive calendar quarters is
            in the form of a 300mg tablet or (b) [****] from the First
            Commercial Sale (as defined in the License Agreement) of the
            Product. The earlier of such dates is referred to herein as the
            "SAVINGS TRIGGER DATE."

      5.3.4 With respect to each of the Process Improvements set forth in
            Section 5.3.1(a)-(c), beginning on the Savings Trigger Date and
            continuing throughout the term of the License Agreement, AstraZeneca
            shall pay to AGIX on a quarterly basis, [****] of any Savings from
            such Process Improvement (as calculated in accordance with Sections
            5.3.5 and 5.3.6 below) times the number of kilograms of Compound
            purchased by AstraZeneca, its Affiliates and Sublicensees (other
            than Third Party Suppliers) during such calendar quarter.

      5.3.5 With respect to the Process Improvements set forth in Section
            5.3.1(b) and (c) the term "SAVINGS" shall mean the difference
            between the per kilogram price of the Compound to AstraZeneca and
            its Affiliates and Sublicensees prior to the Process Implementation
            Date and the per kilogram price of the Compound to AstraZeneca and
            its Affiliates and Sublicensees immediately after the Process
            Implementation Date for such Process Improvement to the extent that
            any such reduction in price is attributable to the implementation of
            such Process Improvement.

      5.3.6 With respect to the Process Improvement set forth in Section
            5.3.1(a), the term "SAVINGS" shall mean (i) for the number of
            kilograms of Compound actually purchased by AstraZeneca, its
            Affiliates and Sublicensees, the difference between the per kilogram
            price of Compound prior to the Process Implementation Date and the
            per kilogram price of Compound to AstraZeneca, its Affiliates and
            Sublicensees, after the Process Implementation Date for such Process
            Improvement (both such prices as set forth specifically in the Dow
            Agreement) plus, (ii) for the number of kilograms of Probucol
            actually purchased by AstraZeneca, its Affiliates and Sublicensees,
            the cost reduction per kilogram as a result of reduced Probucol
            consumption, which cost reduction shall equal the average per
            kilogram price of Probucol during a calendar year times the
            fraction, where the numerator is the difference between the number
            of Probucol

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                       9
<PAGE>

            kilograms required per kilogram of Compound prior to the
            Implementation Date and the number of Probucol kilograms required
            per kilo of Compound after the Process Implementation Date and the
            denominator is the number of Probucol kilograms required per
            kilogram of Compound after the Process Implementation Date.

      5.3.7 The Parties acknowledge and agree that the calculations of Savings
            are based on the financial structure currently set forth in the Dow
            Agreement as of the Effective Date and that AstraZeneca may at any
            time seek to amend the Dow Agreement. In the event that AstraZeneca
            amends the Dow Agreement or structures its relationships with Third
            Party Suppliers in a manner that reduces the amounts that would be
            otherwise paid to AGIX pursuant to this Section 5.3.6 had the Dow
            Agreement remained in effect and unamended, AGIX shall be entitled
            to the amounts that would have been due under the Dow Agreement,
            unless such change was agreed to in advance by AGIX.

      5.3.8 For the avoidance of doubt, all decreases in the price of Compound
            or SDD attributable to the Process Improvement described in Section
            5.3.1(d) shall be retained by AstraZeneca. Furthermore, sales from
            AstraZeneca or any of its Affiliates to a Sublicensee or Affiliate
            shall be disregarded for purposes of the calculations set forth in
            this Section 5.3.

5.4   Capacity Reserve Fee.

      5.4.1 If Regulatory Approval has not been obtained prior to [****], any
            Capacity Reserve Fees due to Dow under the Dow Agreement relating to
            any period prior to [****] shall be paid by AstraZeneca and,
            provided that AstraZeneca performs the validation run of the
            Compound for 2006 as specified in the Dow Agreement, reimbursed by
            AGIX. Thereafter, AstraZeneca shall pay any Capacity Reserve Fees
            due under Section 6.1(c) of the Dow Agreement, however, AGIX shall
            reimburse AstraZeneca for [****] of any Capacity Reserve Fees paid
            by AstraZeneca pursuant to Section 6.1(c) of the Dow Agreement for
            periods prior to receipt of the first Regulatory Approval. Any
            Capacity Reserve Fees that are due under the Dow Agreement for
            periods after receipt of the first Regulatory Approval shall be paid
            solely by AstraZeneca. Any Capacity Reserve Fees for the year in
            which Regulatory Approval is first obtained shall be prorated.

      5.4.2 In the event that AGIX has reimbursed AstraZeneca for a Capacity
            Reserve Fee or a portion thereof and AstraZeneca's, its Affiliates'
            and Sublicensees' orders for that year exceed the minimum quantity
            specified in Section 6.1(b) of the Dow Agreement, AstraZeneca shall
            refund any reimbursement by AGIX for any Capacity Reserve Fee
            reimbursed by AGIX for such year.

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                       10
<PAGE>

      5.4.3 In the event the Dow Agreement is amended after the Effective Date
            hereof, for the purpose of this Section 5.4, AGIX shall receive the
            benefit of any reduction in the Capacity Reserve Fees or minimum
            quantities agreed to in any amendment, but shall not be subject to
            any increases with respect thereto.

      5.4.4 Notwithstanding the provisions of the Dow Agreement, no Capacity
            Reserve Fees or portion thereof shall be payable by AGIX for any
            year in which the total cumulative quantity of Compound ordered by
            AstraZeneca from all of its Third Party Suppliers exceeds the
            minimum quantity specified in Section 6.1(b) of the Dow Agreement.

6     INVOICING, PAYMENT, RECORDKEEPING AND AUDITS

6.1   Except as otherwise provided herein, each Party shall pay all amounts due
      hereunder within thirty (30) days after receipt of an invoice therefor,
      accompanied by evidence of payment of such expenses.

6.2   All past due amounts owed by one Party to the other Party under this
      Agreement shall bear simple interest at the U.S. Prime Rate, as reported
      by the Wall Street Journal, Eastern Edition, on the due date (or the next
      business day if the due date is not a business day), calculated based on
      the number of days between the actual date the payment is made and the
      date the payment was due; provided, however, that in no event shall such
      rate exceed the maximum legal annual interest rate. The payment of such
      interest shall not limit a Party from exercising any other rights it may
      have as a consequence of the lateness of any payment.

6.3   All amounts payable hereunder are:

      6.3.1 exclusive of Indirect Taxes, which, if payable, shall be borne and
            paid by each Party against the provision by the other Party of an
            appropriate Indirect Tax invoice; and

      6.3.2 payable in the Invoice Currency.

6.4   Each Party shall maintain for at least five (5) years, complete and
      accurate books and records in connection with the fees payable hereunder
      as necessary to allow the accurate calculation of the amounts due to the
      other Party hereunder.

6.5   Audits

      6.5.1 Each Party shall permit upon written notice to the other Party, at
            its own expense, a certified public accountant or a person
            possessing similar professional status and associated with an
            independent accounting firm acceptable to the Parties to inspect,
            during normal business hours, and not more than once in any calendar
            year, to audit the other Party's books and records as may be
            reasonably necessary to verify the accuracy of the financial reports
            furnished by the other Party pursuant to this Agreement

                                       11
<PAGE>

            or of any charges, reimbursements or payments made by the other
            Party pursuant to this Agreement, in respect of any Calendar Year
            ending not more than three (3) years prior to the date of such
            notice.

      6.5.2 Each Party recognizes that the Third Party performing any audit for
            a Party may perform accounting services for a Party, and each Party
            hereby waives any conflict of interest relating to the use of such
            accounting firm.

      6.5.3 Upon the expiration of the three (3) years following the end of any
            Calendar Year, the calculation of amounts payable with respect to
            such fiscal year shall be binding and conclusive upon the Parties,
            and the Parties shall be released from any liability or
            accountability with respect to payments for such year.

      6.5.4 The report prepared by any Third Party, if used by a Party, shall
            contain the conclusions of such Third Party regarding the audit and
            shall specify that the amounts paid pursuant thereto were correct
            or, if incorrect, the amount of any underpayment or overpayment.

      6.5.5 In the case of any payments hereunder, if such report shows any
            underpayment by a Party, such Party shall remit to the other Party
            within thirty (30) days after receipt of such report, (A) the amount
            of such underpayment; and (B) if such underpayment exceeds five
            percent (5%) of the total amount owed for the Calendar Year then
            being audited, the reasonable and necessary fees and expenses of
            such Third Party to perform the audit, subject to reasonable
            substantiation thereof. If such report shows any overpayment by a
            Party, then at the audited Party's option, such overpayment shall
            either be refunded to such Party by the other Party within thirty
            (30) days of receipt of the audit report, or be creditable against
            amounts payable by such Party in subsequent payment periods.

      6.5.6 The Parties agree that all information subject to review under this
            Article 6 is Confidential Information and that each Party shall
            retain and cause any Third Party used for any audit to retain all
            such information in confidence.

7     REPRESENTATIONS AND WARRANTIES

7.1   AGIX represents and warrants to AstraZeneca that:

      7.1.1 To the best of AGIX's knowledge as of the Effective Date, the
            performance by AGIX of its obligations to AstraZeneca under this
            Agreement will not breach or be in conflict with any covenant or
            obligation of AGIX to any third party, and, to the best of AGIX's
            knowledge as of the Effective Date, will not infringe the
            Intellectual Property Rights of any Third Party;

                                       12
<PAGE>

      7.1.2 There are no material contracts or other legally binding commitments
            of AGIX relating to the manufacturing, start-up or launch of supply
            of SDD other than the Existing Agreements, and (ii) there are no
            material contracts or other legally binding commitments of AGIX
            relating to the supply of raw materials or services in connection
            with supply of SDD other than the Existing Agreements;

      7.1.3 AGIX represents and warrants to AstraZeneca that

            (a)   the Existing Agreements are in full force and effect and have
                  not been modified or amended other than as shown therein;

            (b)   neither AGIX nor, to the knowledge of AGIX, any other party to
                  an Existing Agreement is in default with respect to a material
                  obligation under, and neither such party has claimed or has
                  grounds upon which to claim that the other party is in default
                  with respect to a material obligation under, an Existing
                  Agreement; and

            (c)   AGIX has not waived or allowed to lapse any of its rights
                  under any Existing Agreement, and no such rights have lapsed
                  or otherwise expired or been terminated. and

      7.1.4 The estimates of Spray Drying Capital Expenditures and the
            Manufacturing Start-Up and Other Costs set forth on Exhibits 2 and 3
            represent AGIX's good faith estimates as of the Effective Date of
            these expenses. For the avoidance of doubt, AGIX makes no
            representation or warranty that actual costs will equal these
            estimated costs.

7.2   EXCEPT AS EXPRESSLY PROVIDED IN THIS AGREEMENT OR THE RELATED AGREEMENTS,
      NEITHER PARTY MAKES ANY OTHER REPRESENTATION OR WARRANTY, EXPRESS OR
      IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, STATUTE, OR OTHERWISE, AND
      EACH PARTY SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED OR STATUTORY
      WARRANTIES INCLUDING WARRANTIES OF MERCHANTABILITY, OF FITNESS FOR A
      PARTICULAR PURPOSE, AND OF NON-INFRINGEMENT.

7.3   NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY FOR INDIRECT, INCIDENTAL,
      CONSEQUENTIAL, OR SPECIAL DAMAGES INCLUDING, BUT NOT LIMITED TO, LOST
      PROFITS ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT,
      REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. HOWEVER,
      NOTHING IN THIS SECTION IS INTENDED TO LIMIT OR RESTRICT THE
      INDEMNIFICATION RIGHTS OR OBLIGATIONS OF EITHER PARTY UNDER ARTICLE 8.

8     INDEMNIFICATION

                                       13
<PAGE>

8.1   AGIX shall defend AstraZeneca, its Affiliates and their respective
      officers, directors, partners, shareholders, employees and agents and
      licensees (the "AZ INDEMNITEES"), at AGIX's cost and expense, and will
      indemnify and hold harmless the AZ Indemnitees from and against any and
      all Losses incurred by or awarded against an AZ Indemnitee only to the
      extent relating to or in connection with any and all claims or actions
      brought by an unaffiliated Third Party against any AZ Indemnitee arising
      out of a breach of a representation, warranty, covenant or obligation set
      forth herein, except to the extent that such Losses are (i) attributable
      to the gross negligence or willful misconduct of the AZ Indemnitees or
      (ii) otherwise subject to an obligation by AstraZeneca to indemnify AGIX
      Indemnitees under Section 8.2.

8.2   Except with respect to Losses required to be indemnified by AGIX pursuant
      to Section 8.1 above, AstraZeneca shall defend AGIX, its Affiliates and
      their respective officers, directors, partners, shareholders, employees
      and agents and licensees (the "AGIX INDEMNITEES"), at AstraZeneca's
      expense, and will indemnify and hold harmless the AGIX Indemnitees from
      and against any and all Losses incurred by or awarded against an AGIX
      Indemnitee relating to or in connection with any and all claims or actions
      brought by an unaffiliated Third Party against a AGIX Indemnitee arising
      out of a breach of a representation, warranty, covenant or obligation set
      forth herein, except to the extent that such Losses are (i) attributable
      to the gross negligence or willful misconduct of the AGIX Indemnitees or
      (ii) otherwise subject to an obligation by AGIX to indemnify AstraZeneca
      Indemnitees under Section 8.1.

8.3   Indemnification Procedures

      8.3.1 Notice. Promptly after an Indemnitee receives notice of a pending or
            threatened claim, demand, suit, action or proceeding brought or
            initiated by a Third Party (an "ACTION"), such Indemnitee shall give
            written notice of the Action to the Indemnifying Party to whom the
            Indemnitee is entitled to look for indemnification pursuant to this
            Article 8. However, an Indemnitee's delay in providing or failure to
            provide such notice shall not relieve the Indemnifying Party of its
            indemnification obligations, except to the extent it can demonstrate
            prejudice due to the delay or lack of notice.

      8.3.2 Defense. Upon receipt of notice under Section 8.3.1 from the
            Indemnitee, the Indemnifying Party shall have the duty to either
            compromise or defend, at its own expense and by counsel (reasonably
            satisfactory to Indemnitee, such Action. The Indemnifying Party
            shall promptly and in any event not more than twenty (20) days after
            receipt of the Indemnitee's original notice) notify the Indemnitee
            in writing that it wishes to assume control of the Action pursuant
            to this Article 8 and of its intention to either compromise or
            defend such Action. The assumption of the defense of an Action by
            the Indemnifying Party shall not be construed as an acknowledgement
            that the Indemnifying Party is liable to indemnify the Indemnitee in
            respect of the Action, nor shall it constitute a waiver by the

                                       14
<PAGE>

            Indemnifying Party of any defenses it may assert against any
            Indemnified Party's claim for indemnification. Once the Indemnifying
            Party gives such notice to the Indemnitee, the Indemnifying Party is
            not liable to the Indemnitee for the fees of other counsel or any
            other expenses subsequently incurred by the Indemnitee in connection
            with such defense, other than the Indemnitee's reasonable costs of
            investigation and cooperation. However, the Indemnitee shall have
            the right to employ separate counsel and to control the defense of
            an Action (and the Indemnifying Party shall bear the reasonable
            fees, costs, and expenses of such counsel) if:

            (a)   the use of the counsel chosen by the Indemnifying Party would
                  present such counsel with a conflict of interest;

            (b)   the actual or potential defendants in, or targets of, such
                  Action include both the Indemnifying Party and the Indemnitee,
                  and the Indemnitee reasonably concludes that there may be
                  legal defenses available to it that are different from or
                  additional to those available to the Indemnifying Party (in
                  which case the Indemnifying Party shall not have the right to
                  assume the defense of such Action on the Indemnitee's behalf);

            (c)   the Indemnifying Party does not employ counsel reasonably
                  satisfactory to the Indemnitee to represent the Indemnitee
                  within a reasonable time after the Indemnitee's notice of such
                  Action; or

            (d)   in the reasonable opinion of counsel to the Indemnitee, the
                  claim could result in the Indemnitee becoming subject to
                  injunctive relief or relief other than the payment of Losses
                  that could have a materially adverse effect on the ongoing
                  business of the Indemnitee; provided, however, that in no
                  event shall the Indemnifying Party be obligated to bear the
                  fees, costs and expenses of more than one (1) separate counsel
                  for all of the other Party's Indemnitees in such Action.

      8.3.3 Cooperation. The Indemnitee shall cooperate fully with the
            Indemnifying Party and its legal representatives in the
            investigation and defense of an Action. The Indemnifying Party shall
            keep the Indemnitee informed on a reasonable and timely basis as to
            the status of such Action (to the extent the Indemnitee is not
            participating in the defense of such Action) and conduct the defense
            of such Action in a prudent manner.

      8.3.4 Settlement. If an Indemnifying Party assumes the defense of an
            Action, no compromise or settlement of such Action may be effected
            by the Indemnifying Party without the Indemnitee's written consent
            (which consent shall not be unreasonably withheld or delayed),
            unless (i) there is no finding or admission of any violation of law
            or any violation of the rights of any person and no effect on any
            other claims that may be made

                                       15
<PAGE>

            against the Indemnitee, (ii) the sole relief provided is monetary
            damages that are paid in full by the Indemnifying Party, and (iii)
            the Indemnitee's rights under this Agreement are not adversely
            affected. If the Indemnifying Party fails to assume defense of an
            Action within a reasonable time, the Indemnitee may settle such
            Action on such terms as it deems appropriate with the consent of the
            Indemnifying Party (which consent shall not be unreasonably
            withheld), and Indemnifying Party shall be obligated to indemnify
            the Indemnitee for such settlement as provided in this Article 8.

8.4   Indemnification Payment Adjustments

      8.4.1 Insurance Proceeds Or Other Recovery. The amount of any Losses for
            which indemnification is provided under this Article 8 shall be
            reduced by the insurance proceeds received and any other amount
            recovered, if any, by the Indemnitee with respect to any Losses. An
            Indemnitee shall mitigate, to the extent such mitigation does not
            otherwise harm such Indemnitee or is otherwise inconsistent with
            this Article 8, any Losses for which indemnification is sought
            hereunder and, to the extent such Losses are covered by Indemnitee's
            insurance, shall pursue an insurance claim relating to such Losses.

      8.4.2 Refund. If an Indemnitee receives a payment pursuant to this Article
            8 and subsequently receives insurance proceeds or other amounts with
            respect to the same Losses, the Indemnitee shall pay to the
            Indemnifying Party an amount equal to the difference (if any)
            between: (i) the sum of the insurance proceeds received, other
            amounts received, and the indemnification amount received from the
            Indemnifying Party pursuant to this Article 8 and (ii) the amount
            necessary to fully and completely indemnify and hold harmless the
            Indemnitee from and against such Losses. However, in no event shall
            such refund ever exceed the Indemnifying Party's payment to the
            Indemnitee under this Article 8.

8.5   Indemnification Payment. Any amount owed by an Indemnitee to a Third
      Person, for which the Indemnifying Party has an obligation under this
      Article 8 to indemnify, shall be due from the Indemnifying Party to the
      Third Person, whether upon entry of judgment, upon settlement, or
      otherwise.

8.6   Survival. The provisions of this Article 8 shall survive any termination
      or expiration of this Agreement. Each Indemnitee's rights under this
      Article 8 shall not be deemed to have been waived or otherwise affected by
      such Indemnitee's waiver of the breach of any obligation, agreement,
      condition, covenant, representation, or warranty contained in, or made
      pursuant to, this Agreement, unless such waiver expressly (and in writing)
      also waives any or all of the Indemnitee's rights under this Article 8.

                                       16
<PAGE>

9     FORCE MAJEURE

9.1   Subject to Section 9.3, a Party's obligations under this Agreement will be
      suspended to the extent and for the duration that its performance is
      delayed, hindered or prevented by circumstances which are not within its
      reasonable control ("FORCE MAJEURE").

9.2   For the purposes of this Section, Force Majeure includes acts or
      restraints of governments or public authorities, war, revolution, riot or
      civil commotion, strikes, lock-outs (except relating to a Party's own
      employees), blockage or embargo, explosion, fire, flood or natural
      disaster and any other events that are beyond the reasonable control of
      the affected Party.

9.3   A Party affected by any event of Force Majeure shall:

      9.3.1 promptly in writing notify the other Party, explaining the nature,
            details and expected duration of such event. Such Party shall also
            notify the other Party from time to time as to when the affected
            Party reasonably expects to resume performance in whole or in part
            of its obligations hereunder, and notify the other Party of the
            cessation of any such event;

      9.3.2 use diligent efforts to resume full performance of its obligations
            under this Agreement as soon as reasonably practical; and

      9.3.3 pending such resumption, use commercially reasonable efforts to
            facilitate any efforts that the other Party may make to procure an
            alternative method by which its obligations under this Agreement may
            be performed.

9.4   If a Party anticipates that an event of Force Majeure may occur, such
      Party shall notify the other Party of the nature, details and expected
      duration of such event.

10    TERM AND TERMINATION

10.1  Term. This Agreement shall be effective during the Term.

10.2  Termination by Either Party. In addition to any other provision of this
      Agreement expressly providing for termination of this Agreement, this
      Agreement may be terminated immediately by either Party upon notice to the
      other Party in the following circumstances:

      10.2.1 in the event of a material breach of this Agreement by the other
             Party, which breach remains uncured for sixty (60) days.

      10.2.2 if the other Party shall file in any court or agency, pursuant to
             any statute or regulation of any state or country, a petition in
             bankruptcy or insolvency or for reorganization or for an the
             appointment of a receiver or trustee of such other Party or of its
             assets, or if the other Party proposes a written agreement of
             composition or extension of its debts, or

                                       17
<PAGE>

             if the other Party shall be served with an involuntary petition
             against it, filed in any insolvency proceeding, or if the other
             Party shall propose or be a party to any dissolution or
             liquidation, or if the other Party shall make an assignment for the
             benefit of its creditors;

      10.2.3 if any encumbrancer takes possession of any material part of the
             assets of the other Party;

      10.2.4 if any distress, execution or other such process is levied or
             enforced upon or against any of the material assets of the other
             Party;

      10.2.5 if the other Party ceases or threatens to cease to carry on the
             whole or substantially the whole of its business or that part of
             its business to which this Agreement relates; or

      10.2.6 if the License Agreement is terminated pursuant to Sections
             13.3(a), 13.3(b), 13.3(c) or 13.3(d) of the License Agreement or
             AGIX terminates the License Agreement pursuant to Section 13.4
             thereof.

10.3  Effect of Termination. Without prejudice to any other rights or remedies
      which either Party may have, upon the termination of this Agreement,
      howsoever the same occurs, each Party shall:

      10.3.1 immediately pay to the other Party all undisputed sums which at the
             date of termination are due and payable to the other Party under
             this Agreement, and

      10.3.2 within thirty (30) days of such termination, at its own expense,
             return to the other Party any property of the other Party in its
             possession, custody or control, including all Confidential
             Information of that Party and copies of it; provided, however, that
             a Party may retain one (1) copy of the other Party's Confidential
             Information in order to ensure compliance with its obligations set
             forth in this Agreement.

10.4  Articles 1, 2, 8, 11-22 and Section 6.4, 6.5, 7.2, 7.3, 10.3, 10.4 and
      with respect to the effects of termination of the License Agreement,
      Sections 4.3 and 5.2.3 will survive expiration or termination of this
      Agreement, howsoever the same occurs.

                                       18
<PAGE>

11    CONFIDENTIALITY

11.1  Nondisclosure Obligation

      11.1.1 Confidential Information. All Information disclosed by one Party to
             the other Party pursuant to this Agreement, including the terms of
             this Agreement ("CONFIDENTIAL INFORMATION"), shall be maintained in
             confidence by the Receiving Party and shall not be disclosed to any
             non-Party or used for any purpose except to exercise its rights and
             perform its obligations under this Agreement without the prior
             written consent of the Disclosing Party, except to the extent that
             the Receiving Party can demonstrate by competent written evidence
             that such Information:

                  (a) is known by the Receiving Party at the time of its receipt
                  and, not through a prior disclosure by the disclosing Party,
                  as documented by the receiving Party's business records;

                  (b) is in the public domain other than as a result of any
                  breach of this Agreement by the Receiving Party;

                  (c) is subsequently disclosed to the Receiving Party on a
                  non-confidential basis by a Third Party who may lawfully do
                  so; or

                  (d) is independently discovered or developed by the Receiving
                  Party without the use of Confidential Information provided by
                  the Disclosing Party, as documented by the Receiving Party's
                  business records.

      11.1.2 Return of Confidential Information Upon Expiration or Termination
             of Agreement. Within thirty (30) days after any expiration or
             termination of this Agreement, each Party shall destroy (and
             certify to the other Party such destruction) or return such
             Confidential Information provided by the other Party as the other
             Party reasonably requests be destroyed or returned; provided,
             however, that (i) the foregoing obligation shall not apply to any
             matter of Confidential Information otherwise provided for in this
             Agreement; and (ii) each Party may retain a single copy of the
             Confidential Information in its confidential legal files for the
             sole purpose of ascertaining its ongoing rights and
             responsibilities regarding the Confidential Information.

11.2  Permitted Disclosures

      11.2.1 Certain Permitted Disclosures. Each Party may disclose Confidential
             Information provided by the other Party without such other Party's
             written consent to the extent such disclosure is reasonably
             necessary in the following instances:

                                       19
<PAGE>

                  (a) disclosure to governmental or other regulatory agencies in
                  order to obtain or maintain patents and to obtain, maintain or
                  amend any regulatory materials regarding SDD or satisfy any
                  other regulatory obligation regarding SDD, but such disclosure
                  may be only to the extent reasonably necessary to obtain
                  patents or obtain, maintain or amend such regulatory
                  materials;

                  (b) complying with applicable court orders or governmental
                  regulations, including without limitation rules or regulations
                  of the Securities and Exchange Commission, or by rules of the
                  National Association of Securities Dealers, any securities
                  exchange or NASDAQ; provided, however, that the receiving
                  Party shall first have given notice to the other Party hereto
                  in order to allow such Party the opportunity to seek
                  confidential treatment of the Confidential Information;

                  (c) disclosure to consultants, agents or other Third Parties
                  (including Third Party Suppliers) solely to the extent
                  required to accomplish the purposes of this Agreement or in
                  connection with due diligence or similar investigations by
                  such Third Parties; provided, however, that such Third Parties
                  agree to be bound by confidentiality and non-use obligations
                  at least equivalent in scope to those contained in this
                  Agreement.

      11.2.2 Written Agreements. Each Party shall obtain written agreements from
             each of its employees and consultants who perform work pursuant to
             this Agreement, which agreements shall obligate such persons to
             similar obligations of confidentiality and to assign to such Party
             all inventions made by such persons during the course of performing
             such work. Each Party will notify the other Party promptly upon
             discovery of any unauthorized use or disclosure of the Confidential
             Information of the other Party.

      11.2.3 Required Disclosure. If a Party is required by judicial or
             administrative process to disclose Confidential Information that is
             subject to the non-disclosure provisions of Section 11.1.1, such
             Party shall promptly inform the other Party of the disclosure that
             is being sought in order to provide the other Party an opportunity
             to challenge or limit the disclosure obligations, provided that
             such Party's obligations to comply with Applicable Laws and
             Regulations shall not be affected by such obligations. Confidential
             Information that is disclosed by judicial or administrative process
             shall remain otherwise subject to the confidentiality and non-use
             provisions of this Article 11, and the Party disclosing
             Confidential Information pursuant to law or court order shall take
             all reasonable steps necessary, including without limitation
             obtaining an order of confidentiality, to ensure the continued
             confidential treatment of such Confidential Information.

                                       20
<PAGE>

11.3  Except as otherwise provided in this Agreement or the License Agreement,
      any Confidential Information which is disclosed by or on behalf of a
      Disclosing Party to the Receiving Party will remain the property of the
      Disclosing Party, and AstraZeneca at all times shall own the AstraZeneca
      Information, and AGIX at all times shall own the AGIX Information.

11.4  The obligations of each Party in this Article 11 will survive for a period
      of ten (10) years after the date of expiration or termination of this
      Agreement.

12    USE OF NAME

12.1  Except as provided under Section 12.2, neither Party may make any
      announcement about the transactions contemplated by this Agreement without
      the prior written consent of the other Party.

12.2  Except as set forth in the License Agreement, each Party shall not mention
      or otherwise use the name, insignia, symbol, trademark, trade name or
      logotype of the other Party or its Affiliates in any publication, press
      release, promotional material or other form of publicity without the prior
      written consent of the other Party in each instance, except for those
      disclosures for which consent has previously been obtained. The
      restrictions imposed by this Article 12 shall not prohibit either Party
      from making any disclosure identifying the other Party that is required by
      applicable law, rule or regulation or the requirements of a national
      securities exchange or another similar regulatory body; provided that any
      such disclosure shall be governed by Article 12. Further, the restrictions
      imposed on each Party under this Article 12 are not intended, and shall
      not be construed, to prohibit a Party from identifying the other Party in
      its internal business communications; provided that any confidential
      information in such communications remains subject to Article 12.

13    NOTICES

13.1  Notice Requirements

      Any notice, request, demand, waiver, consent, approval or other
      communication permitted or required under this Agreement shall be in
      writing and shall be deemed given only if delivered by hand or sent by
      facsimile transmission (with transmission confirmed) or by internationally
      recognized overnight delivery service that maintains records of delivery,
      addressed to the Parties at their respective addresses specified in
      Section 13.2 or to such other addresses of which notice shall have been
      given. Such Notice shall be deemed to have been given as of the date
      delivered by hand or transmitted by facsimile (with transmission
      confirmed) or on the second delivery day after deposit with an
      internationally recognized overnight delivery service. Any notice
      delivered by facsimile shall be confirmed by a hard copy delivered as soon
      as practicable thereafter. This Section is not intended to govern the
      day-to-day business communications

                                       21
<PAGE>

      necessary between the Parties in performing their obligations under the
      terms of this Agreement.

13.2  Address for Notice

      For AstraZeneca:        IPR Pharmaceuticals, Inc.
                              CARR 188 LOTE 17
                              SAN ISIDRO INDUSTRIAL PARK,
                              CANOVANAS, PR 00729
                              Fax: (787) 750-5332
                              Attn: President and General Manager

      With a copy to:         Shiona McGillivray, Senior Legal Counsel
                              AstraZeneca
                              Alderley House
                              Alderley Park
                              Macclesfield
                              Post Code SK10 4TF  England

      For AGIX:               AtheroGenics, Inc.
                              8995 Westside Parkway
                              Alpharetta, Georgia  30004
                              Attn: President and Chief Executive Officer
                              Fax:  (678) 336-2504

      With a copy to:         Arnold & Porter LLP
                              Suite 900
                              1600 Tysons Boulevard
                              McLean, Virginia  22102
                              Attn: Steve Parker, Esq.
                              Fax:  (703) 720-7399

14    RELATIONSHIP OF THE PARTIES

      The status of a Party under this Agreement shall be that of an independent
      contractor. Nothing contained in this Agreement shall be construed as
      creating a partnership, joint venture or agency relationship between the
      Parties or, except as otherwise expressly provided in this Agreement, as
      granting either Party the authority to bind or contract any obligation in
      the name of or on the account of the other Party or to make any
      statements, representations, warranties or commitments on behalf of the
      other Party. All persons employed by a Party shall be employees of such
      Party and not of the other Party and all costs and obligations incurred by
      reason of any such employment shall be for the account and expense of such
      Party.

                                       22
<PAGE>

15    RIGHTS OF THIRD PARTIES

      The provisions of this Agreement are for the sole benefit of the Parties
      and their successors and permitted assigns, and they shall not be
      construed as conferring any rights in any other persons except as
      otherwise provided in this Agreement.

16    ASSIGNMENT

      This Agreement shall inure to the benefit and be binding upon each Party,
      its successors and assigns. The Agreement may not be assigned or otherwise
      transferred, nor, except as expressly provided hereunder, may any right or
      obligation hereunder be assigned or transferred by either Party without
      the prior written consent of the other Party, provided, however, that
      either Party may, without such consent, assign the Agreement and its
      rights and obligations hereunder (i) to an Affiliate, provided such
      Affiliate has the financial resources to perform the obligations of this
      Agreement in the reasonable judgment of the other Party or (ii) in
      connection with the transfer or sale of all or substantially all of its
      assets or business to which this Agreement relates, or in the event of its
      merger or consolidation or change in control or similar transaction, or a
      sale of all or substantially all the pharmaceutical business assets of the
      Party; and provided further, that either Party shall be permitted to sell,
      assign or transfer the right to receive any payments owed by the other
      Party pursuant to this Agreement to one or more Third Parties. Any
      attempted assignment not in accordance with this Article 16 shall be void.

17    ENTIRE AGREEMENT

17.1  This Agreement constitutes the entire agreement between the Parties with
      respect to the subject matter of the Agreement. This Agreement supersedes
      all prior agreements, whether written or oral, with respect to the subject
      matter of the Agreement. Each Party confirms that it is not relying on any
      representations, warranties or covenants of the other Party except as
      specifically set out in this Agreement. Nothing in this Agreement is
      intended to limit or exclude any liability for fraud. All Schedules and/or
      Exhibits referred to in this Agreement are intended to be and are hereby
      specifically incorporated into and made a part of this Agreement.

17.2  Where it is lawful to exclude them, all other conditions, representations
      and warranties which would otherwise be implied (by law or otherwise) will
      not form part of this Agreement.

18    EXPENSES

      Except as otherwise expressly provided in this Agreement, each Party shall
      pay the fees and expenses of its respective lawyers and all other expenses
      and costs incurred by such Party incidental to the negotiation,
      preparation, execution and delivery of this Agreement.

                                       23
<PAGE>

19    WAIVER AND NON-EXCLUSION OF REMEDIES

19.1  A Party's failure to enforce, at any time or for any period of time, any
      provision of this Agreement, or to exercise any right or remedy shall not
      constitute a waiver of that provision, right or remedy or prevent such
      Party from enforcing any or all provisions of this Agreement and
      exercising any rights or remedies. To be effective any waiver must be in
      writing. The rights and remedies provided herein are cumulative and do not
      exclude any other right or remedy provided by law or otherwise available
      except as expressly set forth herein.

19.2  The payment of the invoices by a Party will not operate as any waiver by
      such Party any right, power or remedy provided by law or under this
      Agreement.

20    SEVERABILITY

      To the fullest extent permitted by applicable law, the Parties waive any
      provision of law that would render any provision in this Agreement
      invalid, illegal or unenforceable in any respect. If any provision of this
      Agreement is held to be invalid, illegal or unenforceable, in any respect,
      then such provision will be given no effect by the Parties and shall not
      form part of this Agreement. To the fullest extent permitted by applicable
      law and if the rights or obligations of any Party will not be materially
      and adversely affected, all other provisions of this Agreement shall
      remain in full force and effect and the Parties will use their best
      efforts to negotiate a provision in replacement of the provision held
      invalid, illegal or unenforceable that is consistent with applicable law
      and achieves, as nearly as possible, the original intention of the
      Parties.

21    GOVERNING LAW AND DISPUTES

      The interpretation and construction of this Agreement shall be governed by
      the laws of State of New York excluding any conflicts or choice of law
      rule or principle that might otherwise refer construction or
      interpretation of this Agreement to the substantive law of another
      jurisdiction.

22    EQUITABLE RELIEF

      A breach by either Party of Article 11 may cause irreparable damage and
      the non-breaching Party will not be adequately compensated by monetary
      damages. In the event of a breach, or threatened breach, of Section
      11.1.1, the non-breaching Party shall be entitled to seek from any court
      of competent jurisdiction equitable relief, whether preliminary or
      permanent, without the need to show irreparable harm or the inadequacy of
      monetary damages as a remedy. Nothing in this Article 22 is intended, or
      shall be construed, to limit the Parties' rights to equitable relief or
      any other remedy for a breach of any provision of this Agreement.

                                       24
<PAGE>

23    ENVIRONMENTAL PROVISIONS

      Each Party shall comply with all environmental and occupational safety and
      health laws, rules, regulations and requirements relating to SDD and the
      raw materials used in connection therewith.

24    COUNTERPARTS

      This Agreement may be executed in any number of counterparts, each of
      which shall be deemed an original and all of which taken together shall be
      deemed to constitute one and the same instrument. An executed signature
      page of this Agreement delivered by facsimile transmission shall be as
      effective as an original executed signature page.

                            [Signature Page Follows]

                                       25
<PAGE>

IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date
first set forth above.

IPR PHARMACEUTICALS, INC.                ATHEROGENICS, INC.

By: /s/ RUBEN FREYRE                     By: /s/ RUSSELL M. MEDFORD
    ------------------                       ---------------------------------
Name: Ruben Freyre                       Name: Russell M. Medford, M.D., Ph.D.

Title: President & General Manager       Title: President & CEO

<PAGE>

                                    EXHIBIT 1

                              PROCESS IMPROVEMENTS

PART A: [****]

PART B: [****]

PART C: [****]

PART D: [****]

                                   Exhibit 1-1

---------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

PART A: [****]

                                    Part A-1

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

PART B: [****]

                                    Part B-1

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

PART C: [****]

                                    Part C-1

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

PART D: [****]

                                    Part D-1

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

<PAGE>

                                    EXHIBIT 2

                   ESTIMATED SPRAY DRYING CAPITAL EXPENDITURES

                                     [****]

                                   Exhibit 3-1

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

                                    EXHIBIT 3

                ESTIMATED MANUFACTURING START-UP AND OTHER COSTS

[****]

                                   Exhibit 3-2

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.
<PAGE>

                                    EXHIBIT 4

(1)   The Dow Agreement

(2)   The addenda to the Research Agreement entered into by and between AGIX and
      Dow, dated November 11, 2005.

(3)   [****]

(4)   [****]

-------
[****] indicates that certain confidential information contained in this
document has been omitted pursuant to a request for confidential treatment and
filed separately with the Securities and Exchange Commission.

                                  Exhibit 4-1
<PAGE>

                                    Exhibit 5

                            Dow Consent to Assignment

                                   Exhibit 4-2EX-10.8

 

Exhibit 10.8

FIRST AMENDMENT AND LEASE EXTENSION AGREEMENT

     THIS FIRST AMENDMENT AND LEASE EXTENSION AGREEMENT is made this 19th day of
October, 2004 by and between WESTON PROPERTY INVESTMENT XV, LTD., an Ohio limited liability company
(“Landlord”) and ERICO PRODUCTS, INC., an Ohio corporation (“Tenant”).

WITNESSETH

     WHEREAS, the parties entered into a Lease Agreement dated September 13, 2000 (the “Lease”) for
Landlord’s property located at 31700 Solon Road, Solon, OH 44139, deemed to contain 164,940 square
feet of space (the “Premises”); and

     WHEREAS, the Original Term of the Lease expires on October 31, 2005; and

     WHEREAS, Section 2.1(d) of the Lease provides that, so long as Tenant is not in default of the
Lease beyond any applicable grace periods, Tenant shall have two (2) options to renew the Lease for
five (5) year Terms upon the provision of twelve (12) months advance written notice to Landlord due
by October 31, 2004 and October 31, 2009, respectively, at an increased monthly rental rate for
each successive five (5) year renewal period of 15% over the annual rent for the prior Term of the
Lease; and

     WHEREAS, the parties desire to amend the Lease to (i) extend the Original Term of the Lease;
(ii) establish the Base Rent for the Extended Term and (iii) modify Sections 2.1 (d), (e) and (f).

     NOW THEREFORE, in consideration of the mutual benefits to be derived, the Lease is hereby
amended as follows:

	 	1)	 	The Original Term of the Lease is extended for one (1) year commencing
November 1, 2005 and continuing through and including October 31, 2006 (the “Extended
Term”).
	 
	 	2)	 	The Base Rent for the Extended Term shall be Fifty-Seven Thousand, Seven
Hundred Twenty-Nine Dollars ($57,729.00) which represents a 20% increase over the
annual Base Rent at the expiration of the Original Term.
	 
	 	3)	 	Section 2.1(d) shall be modified to reflect that the date by which Tenant
must notify Landlord of the exercise of Tenant’s options to renew shall be changed to
October 31, 2005 and October 31, 2010, respectively, The first option term shall
commence on November 1, 2006 and continue through and including October 31, 2011. The
second option term shall commence on November 1, 2011 and continue through and
including October 31. 2016.

 

 

	 	4)	 	If tenant exercises its first option to renew for a five (5) year Term,
Landlord shall refund to Tenant the 5% difference between the monthly rental rate the
Tenant would have paid for the first year of the first option term and the monthly
rental rate for the Extended Term, or Twenty-Eight Thousand, Thirty-Nine and 80/100
Dollars ($28,039.80), within thirty (30) days of the exercise of the option.
	 
	 	5)	 	While the parties understand and agree that the Option to Terminate has
expired, the last sentence of Section 2.1 (e) shall be modified to reflect that the
Lease shall remain in full force and effect through the sixth lease year, ending on
October 31, 2006.
	 
	 	6)	 	Section 2.1 (f) shall be modified to reflect that Tenant shall on November 1,
2006, have the option to purchase the premises by providing Landlord with twelve
months advance written notice (due October 31, 2005) of Tenant’s intent to exercise
this purchase option.
	 
	 	7)	 	All of the terms, conditions, provisions and covenants of the original Lease
Agreement, except as specifically modified or amended herein, shall remain in full
force and effect and apply hereto, and Landlord and Tenant agree that the terms of
said Lease as amended herein, shall continue to govern their respective rights and
duties.

     IN WITNESS WHEREOF, the Landlord and Tenant have executed this First Amendment and Lease
Extension Agreement as of the day and year first above written.

	 	 	 	 	 
	WESTON PROPERTY INVESTMENTS XV, LTD
	an Ohio limited liability company
	 
	By:

	 	Weston Inc., Agent	 	 
	 
	 	 	 	 
	By:

	 	/s/ James A. Asher	 	 
	 

	 	 	 	 
	 

	 	James Asher, Exec. V.P./Sec.	 	 

                              “Landlord”

 

 

	 	 	 	 	 	 	 
	STATE OF OHIO

	 	 	)	 	 	 
	 

	 	 	)	 	 	SS
	COUNTY OF CUYAHOGA

	 	 	)	 	 	 

     BEFORE ME, a Notary Public, in and for said county and state, personally appeared the above
named Weston Inc, Agent for WESTON PROPERTY INVESTMENTS XV, LTD., by James A. Asher, its Exec.
V.P./Sec., who acknowledged that he did sign the foregoing instrument and that the same is the free
act and deed of said corporation and his free act and deed as such officer.

     IN WITNESS WHEREOF, I have hereunder set my hand and official seal at Cleveland, Ohio, this
19th day of October, 2004.

	 	 	 	 	 
	 

	 	/s/ Jennifer L. Brosius	 
	 

	 	 	 	 
	 

	 	NOTARY PUBLIC	 
	 
	 	 	 	 
	 

	 	Jennifer L. Brosius	 
	 

	 	Notary Public, State of Ohio	 
	 

	 	Recorded in Cuyahoga County	 
	 

	 	My Commission Expires July 27, 2008	 

ERICO PRODUCTS, INC.

an Ohio corporation

	 	 	 	 	 
	By:

	 	/s/ Peter B. Korte	 	 
	 

	 	 	 	 
	 

	 	Peter B. Korte, General Counsel	 	 

                              “Tenant”

	 	 	 	 	 	 	 
	STATE OF OHIO

	 	 	)	 	 	 
	 

	 	 	)	 	 	SS
	COUNTY OF CUYAHOGA

	 	 	)	 	 	 

     BEFORE ME, a Notary Public, in and for said county and state, personally appeared the above
named ERICO PRODUCTS, INC. by Peter B. Korte, its General Counsel, who acknowledged that he did
sign the foregoing instrument and that the same is the free act and deed of said corporation and
his free act and deed as such officer.

     IN WITNESS WHEREOF, I have hereunder set my hand and official seal at Cleveland, Ohio, this
12th day of October, 2004.

	 	 	 	 	 
	 

	 	/s/ Sandra C. Ketchaver	 
	 

	 	 	 	 
	 

	 	NOTARY PUBLIC	 
	 
	 	 	 	 
	 

	 	Sandra C. Ketchaver	 
	 

	 	Notary Public, State of Ohio	 
	 

	 	Recorded in Cuyahoga County	 
	 

	 	My Commission Expires October 18, 2004

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00099-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00099-of-00352.parquet"}]]