Document:

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                                                                   Exhibit 10.16

                               LICENSE AGREEMENT
                               -----------------

          THIS AGREEMENT is entered into and effective as of the 16th day of
February, 2001, by and between CytRx Corporation, a Delaware corporation, having
a principal office at 154 Technology Parkway, Technology Park/Atlanta, Norcross,
Georgia  30092 ("Licensor"), and Ivy Animal Health, Inc., a Delaware
corporation, having a principal office at 8857 Bond Street, Overland Park,
Kansas  66214 ("Licensee").

          WHEREAS, Licensor is the owner or licensee of, and has the right to
grant licenses to, certain existing proprietary know how, technical information
and patentable subject matter, including certain patents owned by Emory
University ("Emory") and listed on Schedule "A" hereto (the "Licensed Patents"),
all generally relating to growth promotion in poultry and swine (collectively
the "Technology");

          WHEREAS, Licensee desires an exclusive license to make, have made,
develop, use, market and/or sell the methods and compositions covered by the
Technology for non-human use;

          NOW THEREFORE, in consideration of the mutual grants and undertakings
and other good and valuable consideration, the receipt and sufficiency thereof
hereby acknowledged, the parties hereto agree as follows:

          1.  License Grant.  Licensor grants to Licensee a worldwide,
              -------------
irrevocable, exclusive right and license (the "License") to make, have made,
develop, use, market, sell, import and/or export the methods and compositions
covered by (a) the Licensed Patents; (b) any and all U.S. or foreign patents or
applications covering the subject matter of the Technology; (c) any continuation
and/or divisional patents or applications of (a) or (b); and (d) any reissues,
extensions or reexaminations of (a), (b) or (c) for non-human use and to
otherwise use the Technology in conjunction therewith.  Licensor shall provide
Licensee with the technical information, know how and technical assistance
reasonably necessary to allow Licensee to exploit the Technology for non-human
use.

      2.  Consideration.
          -------------

          a.  Initial Payment.  Licensee shall pay to Licensor a one-time single
              ---------------
and fixed lump sum initial payment of One Thousand Dollars ($1,000) upon
execution of this Agreement in consideration for the License.

          b.  Milestone Payments.  Licensee shall pay to Licensor a one-time
              ------------------
single and fixed lump sum milestone payment of One Hundred Thousand Dollars
($100,000) upon Licensee's obtaining regulatory approval in the United States to
market and sell methods or compositions covered by the claims of a Licensed
Patents for non-human use.  Licensee shall be responsible for obtaining any such
regulatory approval, but is not required to seek or obtain any such approval.
No milestone payments shall be due for any non-U.S. approvals.

          c.  Royalty.  Licensee shall pay to Licensor a royalty equal to five
              -------
percent (5 %) of Net Sales of compositions covered by the claims of a Licensed
Patent (a "Licensed
<PAGE>

Product") in any country in which a Licensed Patent is valid and in force. "Net
Sales" shall mean the total gross amount received by Licensee for sales of
Licensed Products less (i) trade, quantity and cash discounts actually allowed,
(ii) credits or allowances given for rejection or return of previously sold
Licensed Products, billing errors or retroactive price reductions, (iii) sales
taxes or other governmental charges levied directly on the sale, transportation
or delivery of the Licensed Products and borne by the Licensee, and (iv)
transportation and related insurance costs actually invoiced. Licensor shall be
solely responsible for payment of any royalty and other amounts due to Emory
resulting from Licensee's performance under this Agreement. During the term of
this Agreement, Licensee shall be responsible for payment of the royalties owed
by CytRx to BASF Corporation ("BASF") under the May 22, 1986 Agreement between
CytRx and BASF, as amended by letter agreement dated February 15, 1990 ("the
BASF Agreement") resulting from Licensee's performance under this Agreement.
Royalties shall be paid during the term of the Agreement on a quarterly basis,
on the last day of March, June, September and December of each year. Payment
shall be accompanied by a report verifying the amount due. If no sales are made
during a quarter, neither the royalty, nor the report, shall be due for that
quarter.

          3.  No Development Requirements.  Licensee shall have no obligation to
              ---------------------------
make, have made, develop, use, market, sell, import or export any methods or
compositions covered by or relating to the Technology.

          4.  Patent Maintenance.  Licensor shall maintain the Licensed Patents
              ------------------
in full force and effect through the maximum term available for each Licensed
Patent.  Licensee shall pay to Licensor an annual maintenance fee of One
Thousand Dollars ($1,000) to be applied to Licensor's costs in maintaining the
Licensed Patents.  It is understood that Licensor is obligated to pay any and
all fees associated with maintenance of the Licensed Patents in excess of the
amount paid to Licensor by Licensee pursuant to this Section 3.

          5.  Improvements. Licensee shall own any improvements or modifications
              ------------
developed by or on behalf of Licensee, relating to the Technology, whether or
not patentable.

          6.  Patent Infringement.  In the event that any infringement of the
              -------------------
Licensed Patents or other Technology rights comes to the attention of either
party, such party shall promptly notify the other party of the infringement.
Licensor shall have the option, but not the obligation, to take steps to abate
the infringement by litigation or otherwise at its sole expense.  Should
Licensor opt not to take, or to cease, any steps to abate such infringement,
Licensee shall have the option to take or continue steps to abate such
infringement at its sole cost or expense, and Licensor agrees to be added as a
legally indispensable party, if necessary.  Licensor and Licensee agree to
assist the other as reasonably necessary in any steps taken to abate the
infringement.

          7.  Indemnity.
              ---------

          a.  Licensor hereby releases, indemnifies, and agrees to defend and
hold harmless Licensee, its sublicensees, agents, servants, employees, officers,
directors, shareholders, and any subsidiary or affiliate of Licensee, from and
against any and all actions, claims, liabilities, losses, damages, costs and
expenses (including legal fees) of every kind,

                                      -2-
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incident to, arising in connection with, or resulting from any
misrepresentation, breach, non-performance or inaccuracy of any representation
or warranty made by Licensor in this Agreement.

          b. Licensee hereby releases, indemnifies, and agrees to defend and
hold harmless Licensor, its agents, servants, employees, officers, directors,
shareholders, and any subsidiary or affiliate of Licensor, from and against any
and all actions, claims, liabilities, losses, damages, costs and expenses
(including legal fees) of every kind, incident to, arising in connection with,
or resulting from, Licensee's negligence in making, developing, using,
marketing, selling, importing or exporting compositions covered by the
Technology.

          8.  Representation and Warranty.  Licensor represents and warrants
              ---------------------------
that it has the legal power and authority to extend the rights granted to
Licensee in this Agreement and that it has not made, and will not make, any
commitments to others inconsistent with or in derogation of such rights.
Licensor shall be solely responsible for assuring that it has the legal power
and authority to extend the license of Emory's interest in the License Patents
granted herein throughout the term of this Agreement.

          Licensor further represents and warrants that, to the best of its
knowledge, Licensee's making, developing, using, marketing, selling, importing
and exporting of any methods and/or compositions covered by the Technology under
this Agreement will not infringe any patent, copyright, trade secret, or other
rights of any third party, including Emory and BASF.  Licensor makes no further
warranties as to the fitness of the technology for any particular purpose or
use.  Licensee agrees to accept the technology on an "as is" basis.

          9.  Term and Termination.
              --------------------

              a.  This Agreement shall continue until the expiration date of
the last patent of the Licensed Patents to expire.

          b.  Either party may terminate this Agreement in the event the other
party commits a material breach of any of the provisions of this Agreement and
fails to cure such breach within thirty (30) days following receipt of written
notice of such breach.

          10.  Notices.  All notices, statements, payments, questions regarding
               -------
billing or otherwise under this Agreement shall be directed to the respective
parties at the addresses identified in the first paragraph hereof (or such other
address as a party may designate by giving written notice to the other party).
Notices shall be deemed delivered when delivered personally or by reputable
courier, or when mailed by United States registered or certified mail with
return receipt requested.

          11.  Waiver.  No waiver by either party of any non-performance or
               ------
violation by the other party of any covenants, obligations or agreements of such
other party hereunder shall be deemed to be a waiver of any subsequent violation
or non-performance of the same or any other covenant, agreement or obligation,
nor shall forbearance by any party be deemed to be waiver by such party of its
rights or remedies with respect to such violation or non-performance.

                                      -3-
<PAGE>

          12.  Assignability.  This Agreement will inure to the benefit of and
               -------------
be binding upon the parties hereto and their respective successors, assigns and
personal representatives.  Any successor or assignee of this Agreement shall
take said assignment subject to the terms hereof.

          13.  Severability.  Should any provision of this Agreement or the
               ------------
application thereof to any extent be held invalid or unenforceable, the
remainder of this Agreement and the application thereof, other than those
provisions as to which it shall have been held invalid or unenforceable, shall
not be affected thereby and shall continue valid and enforceable to the fullest
extent permitted by law.

          14.  Entire Agreement and Modifications.  This Agreement constitutes
               ----------------------------------
the entire agreement between the parties and replaces any prior agreements
between them. No modifications or revisions of this Agreement shall have any
force and effect unless the same are in writing and executed by the parties
hereto.

LICENSOR:                                      LICENSEE:

CYTRX CORPORATION                              IVY ANIMAL HEALTH, INC.

By:  /s/ Jack J. Luchese                       By:  /s/ Richard O. Shuler
   -----------------------                        --------------------------
Name: Jack J. Luchese                          Name:  Richard O. Shuler
      --------------------                           -----------------------
Title: President & CEO                         Title: President & CEO
       -------------------                           -----------------------

                                      -4-
<PAGE>

                                   SCHEDULE A
                                   ----------

<TABLE>
<CAPTION>

 Country         Patent Number                        Title
--------------------------------------------------------------------------------------------------
<S>              <C>                <C>
United States      5,234,683        METHOD OF STIMULATING THE IMMUNE SYSTEM
--------------------------------------------------------------------------------------------------
Australia          596,986          BIOLOGICALLY-ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
Canada             1,279,822        BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
Chile              36,564           BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
China              96,104,742       BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
Germany            228,448          USE OF BIOLOGICALLY ACTIVE COPOLYMERS FOR THE USE OF
                                    MANUFACTURE OF A MEDICAMENT FOR STIMULATING THE GROWTH OF AN
                                    ANIMAL
--------------------------------------------------------------------------------------------------
EPO                228,448          USE OF BIOLOGICALLY ACTIVE COPOLYMERS FOR THE USE OF
                                    MANUFACTURE OF A MEDICAMENT FOR STIMULATING THE GROWTH OF AN
                                    ANIMAL
--------------------------------------------------------------------------------------------------
Spain              556              BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
France             228,448          USE OF BIOLOGICALLY ACTIVE COPOLYMERS FOR THE USE OF
                                    MANUFACTURE OF A MEDICAMENT FOR STIMULATING THE GROWTH OF AN
                                    ANIMAL
--------------------------------------------------------------------------------------------------
United Kingdom     228,448          USE OF BIOLOGICALLY ACTIVE COPOLYMERS FOR THE USE OF
                                    MANUFACTURE OF A MEDICAMENT FOR STIMULATING THE GROWTH OF AN
                                    ANIMAL
--------------------------------------------------------------------------------------------------
Mexico             176,179          BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
Netherlands        228,448          USE OF BIOLOGICALLY ACTIVE COPOLYMERS FOR THE USE OF
                                    MANUFACTURE OF A MEDICAMENT FOR STIMULATING THE GROWTH OF AN
                                    ANIMAL
--------------------------------------------------------------------------------------------------
South Africa       864,556          BIOLOGICALLY ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
United States      5,114,708        BIOLOGICALLY-ACTIVE COPOLYMERS
--------------------------------------------------------------------------------------------------
United States      5,824,322        GROWTH PROMOTING COMPOSITIONS AND METHODS OF USE
--------------------------------------------------------------------------------------------------
</TABLE>

                                      -5-COMMONWEALTH INDUSTRIES, INC.

                                  Amendment to
                    1997 Stock Incentive Plan, as amended and
                             restated April 23, 1999

Effective  December  18,  2000,  the Board of  Directors  adopted the  following
resolution:

RESOLVED,  that the first  sentence of Section 7, titled  Non-Employee  Director
Stock Options and Shares.,  of the  Commonwealth  Industries,  Inc.,  1997 Stock
Incentive Plan, as amended and restated April 23, 1999, be amended to, effective
December 18, 2000, to read in its entirety as follows:

         Nonqualified  Stock Options to purchase  10,000 shares of Common Stock,
         the number of shares being  subject to  adjustment  pursuant to Section
         13, shall be granted  automatically to each  Non-Employee  Director (a)
         upon the date such director  joins the Board or becomes a  Non-Employee
         Director and (b) on each succeeding January 1 which is not less than 90
         days after the date referred to in clause (a).

December 18, 2000.

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