Document:

AGREEEMENT ON PRE-CLINICAL SAFETY ASSESSMENT OF THERAPEUTICAL HIV-PV PSEUDOVIRUS
VACCINE

Instructions

The Agreement is a legal-binding  document that the Bio-Bridge (Beijing) Science
Corporation  (Party A) and the Beijing Institute of Radiation Medicine (Party B)
agree to sign and abide by after mutual consultation.  Both of Party A and Party
B may have its legal representative or an agent designated by the representative
sign the Agreement.

Party A:  Bio-Bridge (Beijing) Science Corporation
Address:  Tianzhu Export Processing Zone, Shunyi District Beijing, China 101312

Legal Representative(pound)-Designated Agent:   Zhi- Guo Weng/Vice President

Party B: Beijing Institute of Radiation Medicine
Address: 27 Taiping Road, Beijing 100850, China

Legal Representative(pound)-Designated Agent: Xiang-Jun Hu

On an equal and voluntary basis, Parties A and B have agreed as follows:

ARTICLE [_]Service Content, Form and Request

Based on the need of Party A, Party A entrusts  Party B Party A entrusts Party B
to finish (a) acute toxicity test; (2) chronic toxicity test;(3)  immunogenicity
and immunological test;(4)safety pharmacology; (5) reproductive toxicity test

Party B should finish the entrusted experiment and issues the complete report.

Party A entrusts Party B to do the safety  evaluation of the pre-clinical  study
of HIV-PV pseudovirus vaccine.  Party B is responsible for enacting testing plan
and consults  with  professionals  in such field.  All tests should be conducted
following the " Provisions for New Drugs  Registration" and related  techniques.
Party B should  submit a testing  report  sealed with official chop to Party and
the content of the report  should  correspond  to the  requirements  of new drug
application.

                                       1
<PAGE>

ARTICLE [_]Work Requirements

Party A:

      1.    Should provide qualified and enough samples in time.

      2.    Should pay the related expense according to Item E.

      3.    Provides the related material for testing.

      4.    Makes sure the final testing plan and final testing report.

Party B:

      1.    Completes the research  according to Item A.

      2.    Provides the testing result in the format of reports.

      3.    Discusses  with  technical  staff  from Party A  regarding  the test
            progress and related issues.

      4.    bears the responsibility of not leaking any information to any party
            or not using the  material  for the purpose of not being  defined in
            the Contract.

      5.    should finish the test reports in the format required by Party A and
            corresponds to the  requirements for applying for clinical study.

      6.    should give Party A invoice  within 10 working days after  receiving
            payment from Party B.

      7.    should  return Party A all  remaining  test  samples  after the test
            finishes.

ARTICLE [_]Period and Method

The  Contract  period  is from  May 6,  2004 to March  15,  2005 and the test is
conducted  at Party B's  laboratory.  If Party A delays in  delivering  samples,
material or in payments,  then the finish time should be postponed  according to
the terms which both parties agree to.

ARTICLE [_] Methods of Inspection and Acceptance

The test report  will be issued in Chinese in  accordance  with the  application
criteria of SFDA of China. Party A confirms the initial report, and Party B will
issue the final test report.  Party B is responsible  for the correctness of the
testing  results,  and will help Party A explain the related results to SFDA. If
any  problems  ensue  because  of  quality  or  implementation,  Party B  should
compensate to make the results perfect at its own expense.

ARTICLE [_] Amount and Method of Payment

The total study fund for this Contract is RMB 800,000. Party A agrees to pay 50%
of the  amount,  RMB  400,000,  within 10 working  days after the signing of the
Contact.  Party A agrees to pay 20% of the amount, RMB 160,000 on April 1, 2005.
After the  acceptance  and  confirmation  of the test reports issued by Party B,
Party A pays the remaining 30% of the amount, RMB 240,000.

Payment method will either be by wire or checks.

                                       2
<PAGE>

ARTICLE [_] Non-disclosure obligation

Party B should not  disclose any secret to any party  without the prior  written
consent from Party A.

ARTICLE [_]Default

A.    If Party A is unable to fufill the obligation  mentioned in Article II and
      thus causes Party B cannot  finish the items  mentioned  in the  Contract,
      Party B will not return the first payment to Party A.

B.    If for reasons  Party B is unable to finish the  service  content in time,
      both  parties can  negotiate  to redo the tests or Party B returns all the
      payments received to Party A.

C.    If either party violates the terms of  non-disclosure  and causes economic
      loss, the defaulting  party should  compensate the other party for all the
      economic loss plus 3% of the Contract amount.

ARTICLE VIII

Any disputes  between the Parties  arising  under or relating to this  Agreement
shall be  taken  legal  proceedings  or be  arbitrated  in  accordance  with the
Agreement within the boundaries of the People's Republic of China.

The attached Plan is viewed as part of the Contract. If there is any change with
regard to the plan,  both  parties  sign  another  supplementary  agreements  to
complete he Contract.

This Agreement consists of 4 original copies, among which Parties A and B keep 2
copies each,  Amendments  and  supplements  can be made when the Parties deem it
necessary and agree to do so after consultations.

        Legal Representative for Party A or Designated Agent

          /s/  Zhi Guo Weng                      (Signature)
        -----------------------------------------
        Legal Representative for Party B or Designated Agent

        /s/    Xiang-Jun Hu                      (Signature)
        -----------------------------------------
        Date of Signature ___6___(Date) __5___(Month)___2004   (Year)

                                       3
<PAGE>

Plan for  Pre-clinical  Safety  Assessment of Therapeutical  HIV-PV  Pseudovirus
Vaccine

      According to Management Method of drug admission,  Technical guidelines to
vaccine  assessment  of gene  therapy  preparation  from  National  Institute of
allergy and Infectious  diseases and SFDA, the following  experimental  plan was
suggested:

(1) acute toxicity test

Animal: nonhuman primate

Dosage: high  dosage (possible maxim dosage), medium dosage, low dosage,
        and medium control

Parameters: general  condition, blood,  biochemical parmeters

Duration: 1 month

(2) chronic toxicity test

                                       4
<PAGE>

Animal: nonhuman primate

Group: normal  control,  low dosage group,  medium  dosage  group,  high dosage
       group,and satellite group

Parameters: general condition, Urinalysis, ECG, Ophthalmologic examination blood
cloting,   blood,   biochemical  parmeters,   plasmid  and  target  gene  tissue
distribution  (PCR),  genomic  integration  of  plasmid,  kinetic  detection  of
expression of taget gene (p24) in serum, necropsy, et al

Duration: 6 month

(3) Immunogenicity and /Immunological test

Animal:   nonhuman  primate

Parameters: antibody IgG  to  p24, to ELDKWA peptide,  to  NWFDIT peptide, et Al

(4) Safety pharmacology

animal: mice and nonhuman primate

Parameters:  spirital  and nerval  system,  cardiovascular  system,  respiratory
system

(5)Reproductive toxicity test
Animal: mice
Parameters: routine
\LAND USE RIGHT AGREEMENT ( THIS IS ONLY A TRANSLATION OF THE ORIGINAL CHINESE
VERSION OF AGREEMENT)

Party A: Beijing Airport High-Tech Park Co. Ltd
Party B: Bio-Bridge Science (Beijing) Co. Ltd

Beijing Airport High-Tech Park Co. Ltd is a legal representative to have the
legal land development right and was approved by Beijing Municipal Government
and Shunyi District People Government.

Party A and Party B reaches the following agreement for Party B's industrial
zone in the Tianzhu Export Processing Zone in accordance with the laws and
provisions of the People's Republic of China.

Article 1

Party A agrees that Party B sets up a biotech engineering and technology project
in Tianzhu Export Processing Zone and the total investment will be US$19
million. Party B's shareholder equity is US$1 million and the annual output will
be RMB 10 billion, with the annual sales is RMB 10 billion, and the annual
profit will be RMB 1 billion. The scope of business are the research and
development, production, and sales of biotech engineering, biotech medicine and
Chinese/western medicine. This Agreement should specify the land location, size,
price ( including the land transfer price for National Land Resource and Housing
Management Bureau of Beijing City and Shunyi District), payment terms and
duration, each party's responsibility.

Article 2 Location, Size and Quality

The location of the land is on the west side of Zhuyuan West Road and the north
side of Zhuyuan second Street. The total area is 17.313 mu ( 2.8 acre) including
construction land 13 mu, and municipal land of 4.313. mu.

Article 3  Land Price

The land which Party A provides should be six tong ( with electricity, water
supply, simple water drainage, communications, heat, and road) and one ping (
the land surface is smooth), and is with 50 year use right. The construction
land price is RMB 225,000 per mu, and the municipal land price is RMB 90,000 per
mu. The total land price is RMB 3,313,170. Party B will pay the amount in
installments.

<PAGE>

Article 4 Payment Method and Terms

After signing the agreement, Party A should pay 50% of the total price for the
construction land, which is RMB 1,462,500.

Within 90 days after the signing of the Agreement, Party B shall sign with the
Bureau of National Land/ Resources and Housing Management for " Agreement for
National Land Use Right". Party B should pay Party A another 50% of the
construction land price, i.e. RMB 1,462,500, within 15 days after signing. Party
A shall provide a copy certificate of the " National Land Use Right" to Party B
within 7 days after receiving the payment.

Party B agrees that it will pays the municipal land price of RMB 388,170 to
Party A before December 31, 2003.

Party A should provide the original certificate of " National Land Use Right" to
Party B within 3 days after receiving the total payment.

Article 5 Responsibilities

1.    Party A should assist Party B during the corporate registration process
      and get National Land Use Right certificate and provide B with all
      material and data for construction planning.

2.    Party A should assist Party B to get all beneficial policies at the
      district and municipal levels.

3.    Party A should make sure the "six tong one ping" condition be achieved
      before singing " National Land Use Right Agreement". The electricity power
      should get to the power room next to Party B. All other municipal pipes
      should be the same with Appendix 3. The ground level height of the Project
      should be within plus or minus 20 centimeters of the road height level
      adjacent to the Project.

4.    Party B should guarantee that the corporate address for
      industrial/commercial purpose, tax purpose and statistics purpose should
      be in Beijing Tianzhu Export Processing Zone.

<PAGE>

5.    Party B should guarantee that the purpose of the land use is for
      industrial project, and should begin to construct with not less than 25%
      of the construction space within one year. The planning of the Project
      should correspond to the total planning of the Export Processing Zone.

6.    Party B can appoint Party A to handle various procedures for construction
      with payment. The content of the service and charge can be negotiated.

7.    The quantity of Party B's water use is 30 tons/per day, and the
      electricity should be 700 KVA.

8.    The new Project of Party B in the Export Processing Zone should correspond
      to environmental protection requirement for the Zone.

Article 6 Defaults

1.    If Party B cannot sign " National Land Use Right" agreement after signing
      the agreement, Party A should return 90% of the first payment to Party B
      after receiving the written notice from Party B.

2.    If the " National Land Use Right" Agreement cannot be singed due to the
      reasons caused by Party A, Party A should return the all the paid amount
      plus 10% of the fist payment by Party B within 2 months.

3.    Party B should pay the total land price within the dates specified in
      Article 4. If Party B is unable to pay the amount on time, then it will
      pay the interest of 0.2% of the unpaid amount per day.

      If Party B is unable to pay the total land price after 2 months of the
      terminated payment date, Party A has the right to discharge from the
      agreement and not return to Party B the paid amount.

4.    Party A shall execute the order of " No.83 Beijing Idle Land Management"
      stipulated by Beijing Municipal Government if Party B idles the land to a
      certain extent not allowed by law.

Article 7

Any disputes between the Parties arising from this Agreement shall be arbitrated
by the Beijing Arbitration Committee.

<PAGE>

Article 8

If there is any change regarding national policies or laws, the Agreement shall
be amended accordingly.

Article 9

If there is any matter not specified in the Agreement, both Parties can sign
amendments. The amendments shall the same legal status as the Agreement.

Article 10

This Agreement consists of 6 original copies, among which Parties A and B keep 3
copies each, The Agreement takes effect after the signing of both Parties.

Appendix 1: Location Map

Appendix 2: Red Line Construction Line Four Angle Map
Appendix 3: Municipal Pipeline Map

Party A: Beijing Airport High-Tech Park Co. Ltd    /s/

Party B: Bio-Bridge Science (Beijing) Co. Ltd      /s/

May 28, 2003

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00083-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00083-of-00352.parquet"}]]