Document:

Exhibit 10.45

 

FIRST
AMENDMENT TO LEASE

 

THIS
FIRST AMENDMENT TO LEASE (the “Amendment”) is entered into this 30 day of October, 2017 (the “Effective
Date”), between MEADOWS LANDMARK LLC, a Delaware limited liability company (“Landlord”), and
CANCER GENETICS, INC., a Delaware corporation (“Tenant”).

 

Landlord
and Tenant are parties to a certain Office Lease Agreement dated October 9, 2007 (the “Lease”) between
Landlord’s predecessor-in-interest Meadows Office, L.L.C. (“MOLLC”) and Tenant, covering an area
(the “Premises”) deemed to contain 17,936 rentable square feet on the second (2nd) floor, located in the
building commonly known as Building 201 of the Meadows Office Complex, whose street address is 201 Route 17 North,
Rutherford, New Jersey (the “Building “).

 

Landlord
has succeeded to the rights and interests of MOLLC as landlord under the Lease.

 

The
Expiration Date (as defined in the Lease) of the Lease is February 28, 2018.

 

Landlord
and Tenant desire (i) to extend the Term (as defined in the Lease) of the Lease, and (ii) to otherwise amend certain terms and
provisions of the Lease, subject to and in accordance with the terms and conditions set forth in this Amendment.

 

In
consideration of the foregoing and of the mutual promises contained in this Amendment, and for other good and valuable consideration
the receipt and sufficiency of which is acknowledged by Landlord and Tenant, and intending to be legally bound hereby, Landlord
and Tenant agree as follows:

 

1.
The New Work. Following the execution and delivery of this Amendment by Landlord and Tenant, Tenant shall perform Alterations
(as defined in the Lease) required by Tenant for Tenant’s continued use and occupancy of the Premises (the “New
Work”), in accordance with Section 8(a) of the Lease. The plans and specifications to be submitted by Tenant
to Landlord for approval of the proposed New Work shall include complete and coordinated working, finished and detailed mechanical,
engineering and construction drawings and specifications for the New Work (the “MEPs”). The MEPs shall include
adequate detail of all existing and proposed systems serving the Premises, including but not limited to HVAC. Tenant shall also
provide to Landlord, with the MEPs, an inventory or schedule of all equipment and systems currently in the Premises and to be
located in the Premises following completion of the New Work, and will update said inventory/schedule at any time that additional
equipment and/or systems are installed the Premises during the Term. The MEPs for the HVAC systems and equipment serving the Premises
shall take into account all such existing and proposed systems and equipment and their impact on HVAC requirements and performance
in the Premises. During the performance of the New Work (but not more frequently than once per calendar month) and upon substantial
completion thereof, provided no Event of Default (as defined in the Lease) is then in existence under the Lease (as amended by
this Amendment), and provided no construction liens have been filed in connection with the New Work, within thirty (30) days after
presentation to Landlord of the items described below with respect to each draw, Landlord shall pay out of the Tenant’s
Allowance (as hereinafter defined) (up to an aggregate total amount equal to Landlord’s NW Cost Obligation (as hereinafter
defined)) for Tenant’s NW Costs (as hereinafter defined) theretofore incurred. Each draw against the Tenant’s Allowance
shall be limited to the proportion that Landlord’s NW Cost Obligation bears to the total Tenant’s NW Costs (as reasonably
estimated by Landlord until such time as the actual amount of Tenant’s NW Costs shall have been determined) (“Landlord’s
NW Cost Proportion”), times the amount then payable to the contractor(s) performing the New Work. In addition, at no
time shall the total amount drawn against the Tenant’s Allowance exceed Landlord’s NW Cost Proportion of the total
of all monies paid through the current draw to the contractor(s) performing New Work. All draws against the Tenant’s Allowance
paid prior to the final draw shall be reduced by a ten percent (10%) retainage (which retainage shall be payable as part of the
final draw). The final draw of Tenant’s Allowance shall not be paid until issuance of a certificate of occupancy (if required
by the Borough of Rutherford) for the New Work and delivery to Landlord of Auto-CAD as-built drawings of the completed New Work.
For purposes of this Section 1, (i) “Tenant’s NW Costs” shall mean actual out-of-pocket hard and
soft construction costs incurred by Tenant in connection with the New Work, including permit and inspection fees and other costs
associated with obtaining necessary permits and approvals and costs of materials and labor used in construction of the New Work,
(ii) “Landlord’s NW Cost Obligation” shall mean the sum of (a) the Tenant’s Allowance less (b)
the fee payable to Landlord’s Construction Manager (as defined in the Lease) pursuant to Section 8(a) of the Lease,
and (iii) “Tenant’s Allowance” shall mean the amount of $269,040.00. Notwithstanding the foregoing, Landlord’s
obligation under this Section 1 to pay Tenant’s NW Costs out of the Tenant’s Allowance shall be applicable
only to Tenant’s NW Costs for New Work completed (and draws submitted therefor) prior to January 1, 2019. Items to be delivered
to Landlord with respect to each draw against Tenant’s Allowance shall include (i) an application for payment and sworn
statement of contractor substantially in the form of AIA Document G-702, Application and Certificate for Payment, covering all
work for which disbursement is to be made to a date specified therein; (ii) a certification from an AIA architect substantially
in the form of the Architect’s Certificate for Payment which is located in said Document G-702; (iii) contractors’,
subcontractors’ and material suppliers’ waivers of liens covering all of the New Work for which payment is requested;
(iv) a cost breakdown for each trade or subcontractor performing the New Work; (v) copies of all construction contracts for the
New Work, with copies of all change orders, if any; and (vi) a request to disburse executed by Tenant containing an approval by
Tenant of the theretofore completed New Work. Tenant shall schedule and coordinate the performance of the New Work with Landlord
so as to minimize disruption with operations of other tenants at the Building and Building operations. Landlord and Tenant acknowledge
that Tenant intends to commence the New Work prior to the Extension Term Commencement Date (as defined below).

 

    	-1-

     

    

 

2.
Extension of Term. The Term is hereby extended for a period (the “Extension Term”) commencing March
1, 2018 (the “Extension Term Commencement Date”), and expiring on February 28, 2023. The Expiration Date is
hereby amended to mean February 28, 2023 (unless sooner terminated in accordance with the Lease, as amended by this Amendment).

 

3.
Base Rent.

 

(a)
Tenant shall continue to pay to Landlord Base Rent (as defined in the Lease) for the Premises through February 28, 2018, in accordance
with the terms of the Lease.

 

(b)
From and after March 1, 2018, Tenant shall pay to Landlord Base Rent for the Premises at the following rates for and during the
following periods:

 

	Rental Period	 	Annual Base Rent per Rentable Square Foot	 	 	Annual Base Rent	 	 	Monthly Installment of Annual Base Rent	 
	3/1/2018 - 2/28/2019	 	$	29.50	 	 	$	529,112.04	 	 	$	44,092.67	 
	3/1/2019 - 2/29/2020	 	$	30.00	 	 	$	538,080.00	 	 	$	44,840.00	 
	3/1/2020 - 2/28/2021	 	$	30.50	 	 	$	547,047.96	 	 	$	45,587.33	 
	3/1/2021 - 2/28-2022	 	$	31.00	 	 	$	556,016.04	 	 	$	46,334.67	 
	3/1/2022 - 2/28/2023	 	$	31.50	 	 	$	564,984.00	 	 	$	47,082.00	 

 

4.
Additional Rent/Taxes. With respect to all periods from and after March 1, 2018, the Base Year (as defined in the Lease)
shall mean the calendar year 2018.

 

5.
HVAC. Notwithstanding the provisions of clause (ii) of Section 7(a)(i) of the Lease (“Landlord’s Building-Standard
HVAC Obligation”), Landlord and Tenant acknowledge and agree:

 

(i)
That Tenant’s use of the Premises is not normal office use, but includes medical laboratory use requiring supplemental HVAC
service beyond the Building standard HVAC service required to be provided by Landlord under the Lease for normal office use;

 

(ii)
That the internal air handling, distribution and control of HVAC within the Premises (including but not limited to supplemental
HVAC units and equipment (the “Existing HVAC Equipment”) was designed and installed by Tenant as part of the
Tenant’s Initial Alterations (as defined in the Lease) under the Lease;

 

(iii)
That all HVAC work performed as part of the New Work will be performed in accordance with Tenant’s plans and specifications
therefor (any HVAC equipment installed as part of the New Work, together with the Existing HVAC Equipment, being herein referred
to together as “Tenant’s HVAC Equipment”);

 

    	-2-

     

    

 

(iv)
That Tenant shall be solely responsible for the maintenance and repair of Tenant’s HVAC Equipment, and shall, as part of
such maintenance and repair, ensure that all of Tenant’s HVAC Equipment (and any other systems or equipment serving the
Premises having an impact on heating, cooling and air quality in the Premises or any other portions of the Building) is properly
filtered and vented to the exterior of the Building, in accordance with all applicable legal requirements and Building standards;
and

 

(v)
That Landlord’s sole obligation with respect to the provision of HVAC to the Premises is to supply heated and refrigerated
air at the entry of the portion of the Building HVAC system serving the Premises into the connection with Tenant’s HVAC
Equipment in such amounts and at such temperatures as would be adequate to heat and cool the Premises in accordance with Landlord’s
Building-Standard HVAC Obligation if the Premises consisted solely of normal office space containing HVAC ducts, air handlers
and controls consistent with Landlord’s Building-standard specifications (it being specifically understood and agreed that
in no event shall Landlord be responsible for the failure of Tenant’s HVAC Equipment to perform in accordance with its design
specifications due to the design, installation, operation or performance thereof).

 

6.
Security Deposit.

 

(a)
The amount of the Security Deposit (as defined in the Lease) to be held by Landlord under the Lease is hereby increased from
its current amount of $300,000.00 to $350,000.00 (to be maintained in such amount throughout the Term, as the same may be
extended or renewed). Tenant shall, simultaneously with Tenant’s execution of this Amendment, deliver to Landlord a
replacement Letter of Credit (as defined in the Lease) in such increased amount of the Security Deposit, whereupon Landlord
shall surrender to Tenant the existing Letter of Credit currently held by Landlord under the Lease.

 

(b)
The second (2nd) subparagraph of Section 6 of the Lease is deleted in its entirety.

 

7.
Termination Option. Provided the Lease, as amended by this Amendment, shall then be in full force and effect, and provided
no Event of Default then exists under the Lease, as amended by this Amendment, Tenant shall have the one-time-only option to terminate
the Term (the “Termination Option”) as of March 31, 2021 (the “Early Termination Date”). The
Termination Option shall be exercised only by Tenant delivering to Landlord not later than twelve (12) months prior to the Early
Termination Date (time being of the essence):

 

(i)
Written notice of Tenant’s exercise of the Termination Option (“Tenant’s Termination Notice”); and

 

(ii)
A termination fee (the “Termination Fee”) (which Termination Fee shall be payable in addition to, and not in
substitution of, any other Rent payable by Tenant under the Lease), in an amount equal to $188,185.38.

 

    	-3-

     

    

 

Provided
Tenant timely and properly exercises the Termination Option described in this Section 7 in the manner set forth above,
the Term shall expire at 11:59 p.m. on the Early Termination Date, and such early termination date shall become the Expiration
Date for all purposes of the Lease, as amended by this Amendment. If Tenant fails to timely and properly exercise the Termination
Option described in this Section 7 in the manner set forth above, the Termination Option shall be null and void.

 

8.
No Renewal Option. Landlord and Tenant acknowledge and confirm that the Renewal Option (as defined in the Lease) provided
under Exhibit H attached to the Lease is hereby deleted in its entirety.

 

9.
Broker. Tenant represents and warrants to Landlord that Tenant has not dealt with any party to whom a commission might
be owing in connection with this Amendment, except for Cushman & Wakefield of New Jersey, Inc., and Colliers International
(together, “Broker”), and shall indemnify, defend and hold harmless Landlord from and against the claim of
any party other than Broker claiming a commission owing due to its dealings with Tenant in connection with this Amendment. Landlord
shall pay any commission payable to Broker in connection with this Amendment under a separate agreement or agreements, and shall
indemnify, defend and hold harmless Tenant from any claim and/or cause of action by Broker for any commission payment or similar
claim.

 

10.
Removal of Alterations. Notwithstanding anything to the contrary set forth in Sections 8(a) and 21 of the Lease regarding
Tenant’s obligation to remove Alterations at the end of the Term (or the Extension Term), such obligation shall extend only
to Alterations made by Tenant or Landlord at Tenant’s request in or to the Premises of a “non-office” nature,
including in any event, but not limited to, lab benches, supplemental air conditioning equipment, specialized appliances, and
any other lab related equipment (collectively, “Specialty Alterations”). However, if Tenant is notified by
Landlord to the contrary not less than six (6) months prior to the Expiration Date, Tenant shall deliver possession of the Premises
to Tenant with the Specialty Alterations, to the extent designated by Landlord, remaining in the Premises.

 

11.
Miscellaneous. If there is any conflict between the terms and provisions of the Lease and the terms and provisions of this
Amendment, the terms and provisions of this Amendment shall prevail. Landlord and Tenant ratify and affirm the Lease as modified
by this Amendment. Except as modified by this Amendment, the Lease shall remain unmodified, in full force and effect. Except as
herein otherwise expressly provided, or except as the terms of the Lease may be in conflict with or inconsistent with the terms
of this Amendment, all of the terms, covenants and provisions of the Lease are hereby incorporated into and made a part of this
Amendment as if fully set forth herein. Tenant represents that, as of the date hereof, it has no defenses or accrued offsets under
the Lease and, to Tenant’s actual knowledge, Landlord is not in default of its obligations under the Lease.

 

[BALANCE
OF THIS PAGE INTENTIONALLY LEFT BLANK- SIGNATURE PAGE TO FOLLOW]

 

    	-4-

     

    

 

IN
WITNESS WHEREOF, Landlord and Tenant have executed this Amendment on the day and year first above written.

 

	WITNESS/ATTEST	MEADOWS LANDMARK LLC,

                                                                                a Delaware limited liability company

	 	 	 
	 	By:	/s/
    Barbara A. Carley
	 	Print
    name and title:	Barbara
    A. Carley
	 		Authorized
    Person
	 	 	 
	 	CANCER GENETICS, INC.,  

                                                                                a Delaware corporation

	 	 	 
	 	By	/s/
    John A. Roberts
	 	Print
    name and title	John
    A. Roberts, COO

 

    	-5-Exhibit 10.46

 

CONSENT
TO ASSIGNMENT

 

This
Consent to Assignment (this “Agreement”) is executed as of July 19, 2019, between Meadows Landmark
LLC, a Delaware limited liability company (“Landlord”), Cancer Genetics, Inc., a Delaware
corporation (“Assignor”), Interpace BioPharma, Inc., a Delaware corporation (“Assignee”).

 

RECITALS:

 

A.
Assignor is the tenant under a certain Office Lease Agreement, dated October 9, 2007, between Meadows Office, L.L.C. (“MOLLC”),
as landlord, and Assignor, as tenant, as amended by a certain First Amendment to Lease, dated October 30, 2017, between Landlord
(successor to MOLLC), as landlord, and Assignor, as tenant (collectively, the “Lease”).

 

B.
Assignor desires to assign unto Assignee all of Assignor’s rights, title and interest as tenant in and to the Lease, and
Assignee desires to accepts such assignment and to assume and be bound by and to perform all duties and obligations as tenant
under the Lease. Assignor and Assignee have requested that Landlord consent to such assignment and assumption (the “Assignment”),
and Landlord has agreed thereto, subject to and in accordance with the terms and conditions contained herein.

 

AGREEMENTS

 

For
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows:

 

1.
Consent. Subject to and in accordance with the terms and conditions contained in this Agreement, Landlord hereby
consents to the Assignment and waives any applicable termination or other rights under the Lease arising solely in connection
with the Assignment. The Assignment shall be effectuated pursuant to an assignment of lease between Assignor and Assignee, the
exact form of which is attached hereto as Exhibit A (the “Assignment”). Landlord’s consent
contained herein shall not waive its rights as to any subsequent assignment, sublease or other transfer. Landlord hereby asserts
that that, to Landlord’s actual knowledge, the Lease is in full force and effect and acknowledges that, upon receipt by
Landlord of the full amount of the outstanding rent as set forth in Section 4 of the Assignment (and any additional amounts of
rent becoming due under the Lease prior to the date of Landlord’s execution and delivery of this Agreement), there is no
default of Assignor under the Lease which has remained uncured after any applicable period for notice and cure and no circumstance
or set of circumstances exists (including the Assignment) which, with the giving of notice or the passage of time, or both, would
constitute a default under the Lease.

 

2.
No Obligations Created. Each of the parties to this Agreement agree and acknowledge that Landlord shall have no
obligation or liability under the terms of the Assignment. Without limiting the generality of the foregoing, Landlord shall have
no liability (and shall not be bound by) any modifications, deletions or waivers of any provision of the Lease which Landlord
has not agreed to specifically in writing.

 

    	1

     

    

 

3.
Condition of Premises. Landlord makes no representations or warranties, express or implied, concerning the condition
of the Premises (as defined in the Lease) and Assignee accepts the Premises in their “as-is” condition as of the effective
date of the Assignment.

 

4.
Guaranty. In order to induce Landlord to enter into this Agreement, and in consideration of Landlord’s entering
into this Agreement, the full and faithful keeping, performance and observance of all the covenants, agreements, terms, provisions
and conditions of the Lease provided to be kept, performed and observed by the tenant thereunder (expressly including, without
being limited to, the payment as and when due of the Base Rent (as defined in the Lease) and additional Rent (as defined in the
Lease) payable by the tenant under the Lease) and the payment of any and all other damages for which the tenant under the Lease
shall be liable by reason of any act or omission contrary to any of said covenants, agreements, terms, provisions or conditions
is being guaranteed by Interpace Diagnostics Group, Inc. (“Guarantor”), by the execution by Guarantor
of the Guaranty attached to and made a part of the Assignment as Exhibit B (the “Guaranty”).
Assignor and Assignee confirm and acknowledge that Landlord would not have entered into this Agreement but for the giving of the
Guaranty by Guarantor.

 

5.
Brokerage. In no event shall Landlord be liable for any leasing or brokerage commission with respect to the Assignment
or the negotiation and execution of the Assignment or this Agreement. Assignor and Assignee shall each jointly and severally indemnify,
defend and hold Landlord harmless from and against all costs, expenses, attorney’s fees and other liability for commissions
or other compensation claimed by any broker or agent claiming the same by, through or under the indemnifying party with respect
to the Assignment or this Agreement.

 

6.
Landlord’s Costs. Assignee shall, upon delivery of an invoice therefor; reimburse Landlord for all of Landlord’s
costs and expenses (including legal fees incurred by Landlord) incurred in connection with the Assignment and this Agreement.

 

7.
Governing Law; Amendment; Entire Agreement. This Agreement shall be governed by the laws of the State of New Jersey.
This Agreement shall not be amended or modified except by an instrument in writing signed by all the parties hereto and this Agreement
contains all of the agreements, understandings, representations and warranties of the parties with respect to the subject matter
hereof.

 

8.
Counterparts. This Agreement may be executed in multiple counterparts, each of which shall constitute an original,
but all of which shall constitute one document. Such counterparts may be transmitted electronically and any such electronically
transmitted counterparts shall be deemed to be an original executed counterpart.

 

[SIGNATURE
PAGE FOLLOWS]

 

    	2

     

    

 

EXECUTED
as of the date first written above.

 

	 LANDLORD:	MEADOWS
    LANDMARK LLC, a Delaware limited liability company
	 	 	 
	 	By:	/s/
    John H. Rooser
	 	Name:	John
H. Rooser
	 	Title:	Authorized
Person
	 	 
	 ASSIGNOR:	CANCER
    GENETICS, INC., a Delaware corporation
	 	 	 
	 	By:	/s/
    John A. Roberts
	 	Name:	John
A. Roberts 
	 	Title:	President
& CEO
	 	 
	ASSIGNEE:	INTERPACE
    BIOPHARMA, INC., a Delaware corporation
	 	 	 
	 	By:	/s/
    Jack Stover
	 	 	Jack
Stover
	 	 	President
and Chief Executive Officer

 

[Signature
Page to Cancer Genetics, Inc. Consent to NJ Lease Assignment]

 

    	3

     

    

 

EXHIBIT
A

 

Lease
Assignment

 

[Intentionally
omitted]

 

    	 

     

    

 

EXHIBIT
B

 

Form
of Guaranty

 

[Intentionally
omitted]

 

    	 

     

    

 

EXHIBIT
C

 

Form
of Consent to Assignment

 

[Intentionally
omitted]

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