Document:

Security Agreement (Patents) by MDRNA Research, Inc.

 Exhibit 10.6 
 EXECUTION COPY 
 SECURITY AGREEMENT (PATENTS)

 WHEREAS, MDRNA RESEARCH, INC., a Delaware corporation, with a principal place of business at 3830 Monte Villa Parkway,
Bothell, Washington 98021 (the “Company”) and CEQUENT PHARMACEUTICALS, INC., a Delaware corporation, with a place of business at One Kendall Square, Building 700, Cambridge, Massachusetts 02139 (the “Lender”) have entered into a
Security Agreement (All Assets) dated March 31, 2010 (as amended, the “Security Agreement”), which Security Agreement was executed in connection a loan agreement (as amended, the “Loan Agreement”) between MDRNA, Inc., the
corporate parent of the Company, and the Lender; and 
 WHEREAS, the Company is the owner of the registered United States
Patents (“U.S. Patents”) and United States Patent Applications (“U.S. Applications”) listed on Schedule A hereto; and 
 WHEREAS, among the security interests granted by the Company to the Lender pursuant to the Security Agreement is a security interest in the U.S. Patents and U.S. Applications listed on Schedule A
hereto and in any registered patents which may hereafter issue in respect of such U.S. Applications; and 
 WHEREAS, the parties
to the Security Agreement contemplate and intend that, if an Event of Default (as defined in the Loan Agreement) shall occur and be continuing, the Lender shall have all rights of a foreclosing secured party in and to the U.S. Patents and U.S.
Applications and any registered patents which may hereafter issue in respect of such U.S. Applications and any proceeds thereof, including, without limitation, the right, following such foreclosure, to transfer to a purchaser all of the
Company’s right, title and interest in and to the U.S. Patents and U.S. Applications and any registered patents which may hereafter issue in respect of such U.S. Applications; 
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties reconfirm the
terms of the Security Agreement, as if set forth fully herein, and acknowledge that the Lender has a security interest in the U.S. Patents and U.S. Applications listed on Schedule A hereto and in any registered patents which may hereafter issue in
respect of such U.S. Applications; as security for the Obligations (as defined in the Security Agreement) the Company hereby collaterally assigns to the Lender, and grants a security interest to the Lender in and to, all of the Company’s right,
title and interest in and to said U.S. Patents and U.S. Applications and any registered patents which may hereafter issue in respect of such U.S. Applications; the Company agrees that except as permitted by the Security Agreement, it will not sell
or assign any of the U.S. Patents, any of the U.S. Applications or any registered patents which may hereafter issue in respect of such U.S. Applications without the prior written consent of the Lender; and the Company and the Lender request that the
Commissioner of Patents and Trademarks record this document with respect to the U.S. Patents and U.S. Applications. 

 The Company hereby appoints the Lender as the Company’s attorney-in-fact (with full
power of substitution and resubstitution) with the power and authority, after the occurrence and during the continuance of any Event of Default (as defined in the Loan Agreement), to execute and deliver, in the name and on behalf of the Company, and
to cause the recording of all such further assignments and other instruments as the Lender may deem necessary or desirable in order to carry out the intent of the Security Agreement and this Security Agreement (Patents). The Company agrees that all
third parties may conclusively rely on any such further assignment or other instrument, so executed, delivered and recorded by the Lender (or the Lender’s designee in accordance with the terms hereof) and on the statements made therein.

  

									
	MDRNA RESEARCH, INC.	 		 	CEQUENT PHARMACEUTICALS, INC.,
					
	By:	 	 /s/ J. Michael French
	 		 	By:	 	 /s/ Peter D. Parker

	Name:	 	J. Michael French	 		 	Name:	 	Peter D. Parker
	Title:	 	President	 		 	Title:	 	President and Chief Executive Officer

 Signature Page to Security Agreement (Patents) 

 SCHEDULE A 
 TO 
 SECURITY AGREEMENT (PATENTS) 
 Patents with United States Registration 
  

					
	 Patent Description
	 	 Registration No.
	 	 Issue Date

			
		 		 	

  

					
	 United States Patent Applications
	 		 	
			
	 Description
	 	 Serial No.
	 	 Filing DateGuanranty Agreement

 Exhibit 10.7 
 EXECUTION COPY 
 GUARANTY AGREEMENT

 GUARANTY AGREEMENT dated as of March 31, 2010 from Atossa HealthCare, Inc., a Delaware corporation
(“Healthcare”), MDRNA Research, Inc., a Delaware corporation (“Research”), and Calais Acquisition Corp., a Delaware corporation (“Merger Sub”) (Healthcare, Research and Merger Sub being hereinafter
referred to, collectively, as “Guarantors” and, individually, as a “Guarantor”), to Cequent Pharmaceuticals, Inc., a Delaware corporation (“Lender”). 
 WITNESSETH: 
 WHEREAS, MDRNA, Inc., a Delaware corporation (“Borrower”), and Lender are entering into that certain Loan Agreement dated as of the date hereof (as amended, restated, supplemented and/or otherwise modified from time to
time, the “Loan Agreement”), pursuant to which Lender will establish a facility for a term loan (the “Loan”) that may be advanced to the Borrower in installments; and 
 WHEREAS, the Loan is evidenced by the Borrower’s promissory note (as amended, restated, supplemented and/or otherwise modified from
time to time, the “Note”) in an aggregate face principal amount of $3,000,000, payable to the order of Lender; and 
 WHEREAS, in order to induce the Lender to enter into the Loan Agreement, the Borrower has agreed to obtain and deliver this Agreement; and 
 WHEREAS, the Guarantors are wholly-owned subsidiaries of the Borrower and participate in a common business enterprise with the Borrower; and 
 WHEREAS, the Lender’s agreement to enter into the Loan Agreement is and will be beneficial to each Guarantor, as each Guarantor has a
significant economic interest in the strength and success of the Borrower; 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the Guarantors hereby jointly and severally agree as follows: 
 ARTICLE I 
 CERTAIN DEFINITIONS 
 Section 1.01. Defined Terms. As used in this Agreement, the following terms shall have the meanings set out respectively after
each: 
 “Agreement” – This Guaranty Agreement, as same may be from time to time amended. 
 “Business Day” – As defined in the Loan Agreement. 

 “Environmental Event” – Each of (i) the generation, storage,
disposal, removal, transportation or treatment of Hazardous Substances on any property owned, occupied or operated by any Guarantor or any Subsidiary of a Guarantor; (ii) the receipt by any Guarantor or by any Subsidiary of a Guarantor of any
notice or claim of any violation of any Environmental Law or of any action based upon nuisance, negligence or other tort theory alleging liability on the basis of improper generation, storage, disposal, removal, transportation or treatment of
Hazardous Substances on any affected property; or (iii) the presence or release of Hazardous Substances at or upon any property owned, occupied or operated by any Guarantor or any Subsidiary of a Guarantor that has resulted in contamination or
deterioration of any property resulting in a level of contamination greater than the levels permitted or established by any Governmental Authority of competent jurisdiction. 
 “Governmental Authority” – As defined in the Loan Agreement. 
 “Guaranteed Obligations” – Any and all indebtedness, liabilities or obligations of the Borrower, joint or several,
direct or indirect, absolute or contingent, due or to become due, now existing or hereafter arising, to or for the benefit of the Lender arising out of or provided for in any of the Loan Documents or the Merger Agreement, such term to include
obligations to perform acts and refrain from taking action as well as obligations to pay money. 
 “Guarantors’
Agreements” – Collectively, this Agreement, the Security Agreement and any other instrument, document or other agreement between any one or more of the Guarantors and the Lender or given by any one or more of the Guarantors to the
Lender, whether now existing or hereafter arising. 
 “Guaranty” – The guaranty of the Guarantors set
forth in Section 2.01 below. 
 “Hazardous Substances” – As defined in the Loan Agreement.

 “Indebtedness” – As defined in the Loan Agreement. 
 “Loan Documents” – The Loan Agreement, the Note, the Security Agreement and any other instruments, documents or other
agreements made by the Borrower with or in favor of the Lender in connection with the Loan, whether now existing or hereafter entered into or delivered. 
 “Merger Agreement” – As defined in the Loan Agreement. 
 “Person” – As defined in the Loan Agreement. 
 “Security Agreement” – The
Security Agreement (All Assets) of even date herewith given by the Borrower and the Guarantors to the Lender. 
 Capitalized terms defined in
the Loan Agreement and not otherwise defined herein shall have the respective meanings set forth in the Loan Agreement. 
 Section 1.02. Use of Defined Terms. Any defined term used in the plural preceded by the definite article shall be taken to encompass all members of the relevant class. Any defined

  

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term used in the singular preceded by “any” shall be taken to indicate any number of the members of the relevant class. 
 ARTICLE II 
 THE GUARANTY 
 Section 2.01. Guaranty. In consideration of the Lender entering into the Loan Agreement, the Guarantors hereby jointly and
severally guaranty to the Lender the due and punctual payment of all of the Guaranteed Obligations, as and when the same shall become due and payable, whether on demand or at maturity, by declaration or otherwise, according to the terms thereof, and
all losses, costs, expenses and reasonable attorneys’ fees and disbursements incurred by reason of a default under any of said Guaranteed Obligations. In case of any failure by the Borrower punctually to pay any of the Guaranteed Obligations,
the Guarantors unconditionally, jointly and severally agree to cause such payment to be made punctually as and when the same shall become due, whether at maturity or by declaration or otherwise, and as if such payment were made by the Borrower. This
Guaranty is an absolute, unlimited, unconditional and continuing guaranty of the full and punctual payment by the Borrower of the Guaranteed Obligations and not merely of their collectibility, and is in no way conditioned upon any requirement that
the Lender first collect or attempt to collect the Guaranteed Obligations or any portion thereof from the Borrower or from any other guarantor (nor, as to any Guarantor, from any other Guarantor) of any of same or resort to any security or other
means of obtaining payment of any of the Guaranteed Obligations that the Lender now has or may acquire after the date hereof, or upon any other contingency whatsoever. Upon the occurrence of any Event of Default (as defined herein) and written
notice thereof to the Guarantors, all liabilities and obligations of each Guarantor to the Lender shall, at the option of the Lender, become due and payable to the Lender without further demand or notice of any nature, all of which are expressly
waived by the Guarantors. Payments by the Guarantors hereunder may be required by the Lender on any number of occasions. 
 Section 2.02. Guarantors’ Further Agreements to Pay. The Guarantors further jointly and severally agree, as principal obligors and not as guarantors, to pay to the Lender, on demand, in funds immediately available to the
Lender, all costs and expenses (including court costs and reasonable attorneys’ fees and disbursements) incurred or expended by the Lender in connection with the enforcement of this Guaranty, together with interest on any sum now or hereafter
payable by the Guarantors under this Agreement, such interest to accrue from the date of demand for any payment to the date of actual payment. Such interest will be payable at the rate set forth in Section 6.04 below. 
 Section 2.03. Freedom to Deal with Borrower and Other Parties. The Lender shall be at liberty, without giving notice to or
obtaining the assent of any Guarantor and without relieving any Guarantor of any liability hereunder, to deal with each other Guarantor, with the Borrower and with each other party who now is or after the date hereof becomes liable in any manner for
any of the Guaranteed Obligations in such manner as the Lender in its sole discretion deems fit. The Lender may in its sole discretion (to the extent permitted by the Loan Agreement) do any or all of the following things, none of which shall
discharge or affect any Guarantor’s liability

  

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hereunder: (i) extend credit, make loans and afford other financial accommodations to the Borrower at such times, in such amounts and on such terms as the Lender may approve;
(ii) modify, amend, vary the terms and grant extensions or renewals of any present or future indebtedness or of all or any of the Guaranteed Obligations held by Lender or any instrument relating to or securing same; (iii) grant time,
waivers and other indulgences in respect thereto; (iv) vary, exchange, release or discharge, wholly or partially, or delay or abstain from perfecting and enforcing any security or guaranty held by Lender (including, as to any Guarantor,
varying, exchanging, releasing, discharging or delaying or abstaining to enforce this Guaranty with respect to any other Guarantor ) or other means of obtaining payment of any of the Guaranteed Obligations that the Lender now has or acquires after
the date hereof; (v) take or omit to take any of the actions referred to in the Loan Documents or other instrument evidencing, securing or relating to any of the Guaranteed Obligations or any actions under this Agreement; (vi) fail, omit
or delay to enforce, assert or exercise any right, power or remedy conferred on the Lender in this Agreement or in any other Loan Document or other instrument evidencing, securing or relating to any of the Guaranteed Obligations or take or refrain
from taking any other action; (vii) accept partial payments from the Borrower or any other party; (viii) as to any Guaranteed Obligations held by Lender, release or discharge, wholly or partially, any other Guarantor, any endorser or any
guarantor, or accept additional collateral for the payment of any Guaranteed Obligations held by Lender; (ix) compromise or make any settlement or other arrangement with the Borrower or any other Person as to the Guaranteed Obligations held by
Lender; and (x) consent to and participate in the proceeds of any assignment, trust or mortgage for the benefit of creditors as to the Guaranteed Obligations held by Lender. 
 Section 2.04. Unenforceability of Guaranteed Obligations; Invalidity of Security or Other Guaranties. If for any reason now or
hereafter the Borrower has no legal existence or is under no legal obligation to discharge any of the Guaranteed Obligations undertaken or purported to be undertaken by it or on its behalf, or if any of the moneys included in the Guaranteed
Obligations have become irrecoverable from the Borrower by operation of law or for any other reason, this Agreement shall nevertheless be binding on the Guarantors jointly and severally to the same extent as if the Guarantors at all times had been
the joint and several principal debtors on all of the Guaranteed Obligations (and no invalidity or unenforceability as to one Guarantor shall affect the obligations of any other Guarantor hereunder). This Agreement shall be in addition to any other
guaranty or other security for the Guaranteed Obligations, and it shall not be prejudiced or rendered unenforceable by the invalidity of any such other guaranty or security. The liability of each Guarantor under this Agreement shall remain in full
force and effect until payment and performance in full of all of the Guaranteed Obligations. This Agreement shall continue to be effective or be reinstated, as the case may be, if at any time any payment of any of the Guaranteed Obligations is
rescinded or must otherwise be restored or returned by the Lender upon the insolvency, bankruptcy or reorganization of the Borrower, any Guarantor or otherwise, all as though such payment had not been made. 
 Section 2.05. Waivers by Guarantors. Each Guarantor waives: notice of acceptance hereof and reliance hereon, notice of any
action taken or omitted by the Lender in reliance hereon, any requirement that the Lender be diligent or prompt in making demands hereunder, any requirement as to any presentment, demand, protest, giving notice of any default by the Borrower (except
as otherwise specifically required under the Loan Agreement) or asserting any other right

  

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of the Lender hereunder and all demands, notices (except as aforesaid) and all suretyship defenses generally. Each Guarantor also irrevocably waives, to the fullest extent permitted by law, all
defenses which at any time may be available in respect of such Guarantor’s obligations hereunder by virtue of any statute of limitations, valuation, stay, homestead or moratorium law or other similar law now or hereafter in effect. 

Without limiting the generality of the foregoing provisions of this Agreement, the liability of each Guarantor shall not be released,
discharged or otherwise affected by: 
 (i) any extension, renewal, settlement, compromise, waiver or release in respect of any
obligation of the Borrower, any other Guarantor or any other guarantor of any of the Guaranteed Obligations; 
 (ii) any change
in the time, manner, amount or place of payment of any Guaranteed Obligation or any modification or amendment of or supplement to any Loan Document or this Agreement; 
 (iii) any release, non-perfection or invalidity of any direct or indirect security for any obligation of the Borrower, any Guarantor or any other guarantor of any of the Guaranteed Obligations;

 (iv) any change in the legal existence, structure, record or beneficial ownership or control of the Borrower, any Guarantor
or any other guarantor of any of the Guaranteed Obligations, or any insolvency, bankruptcy, reorganization or other similar proceeding affecting any such Person or its assets; 
 (v) the existence of any claim, set-off or other rights that any Guarantor may have at any time against the Borrower, the Lender, any
Guarantor or any other guarantor of any of the Guaranteed Obligations or any other Person, whether or not arising in connection with this Agreement; 
 (vi) any invalidity or unenforceability relating to or against the Borrower or any Guarantor for any reason under any Loan Document or under this Agreement; or any provision of applicable law or
regulation purporting to prohibit the payment by any Person of the principal of or interest on the Note or any other amount payable under any Loan Document or under this Agreement; or 
 (vii) any other act or omission to act or delay of any kind by the Borrower, any other Guarantor, the Lender, or any other Person or any
other circumstances whatsoever that might, but for the provisions of this paragraph, constitute a legal or equitable discharge of any Guarantor’s obligations hereunder. 
 Section 2.06. Subrogation. Unless and until all Guaranteed Obligations shall have been indefeasibly paid in full and discharged,
each Guarantor hereby irrevocably and unconditionally waives enforcement of any and all rights of subrogation, contribution or similar rights that, but for this Section 2.06, such Guarantor might otherwise have in relation to the Borrower, any
other Guarantor or any other guarantor as a result of this Agreement. No right of subrogation,

  

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contribution or any similar rights will in any event be deemed to give any Guarantor any cause of action against the Lender or any of its respective officers, employees or agents for any act or
omission on the part of the Lender; the Lender may, without liability, release or fail to perfect any security interest and may take or omit to take any action under any of the Loan Documents, even if same would reduce the value of any
Guarantor’s subrogation or similar rights. 
 Section 2.07. No Contest with Lender. No set-off, counterclaim,
reduction or diminution of any obligation, or any claim or defense of any kind or nature that any Guarantor has or may have against the Borrower, any other Guarantor, any other guarantor, or the Lender, as the case may be, shall be available
hereunder to any Guarantor. No Guarantor will, in any proceedings under the Bankruptcy Code or insolvency proceedings of any nature, prove in competition with the Lender in respect of any payment hereunder or be entitled to have the benefit of any
counterclaim or proof of claim or dividend or payment by or on behalf of the Borrower or the benefit of any other security for any Guaranteed Obligation that, now or hereafter, any Guarantor may hold in competition with the Lender. 
 Section 2.08. Stay of Acceleration. If acceleration of the time for payment of any amount payable by the Borrower under any Loan
Document is stayed upon the insolvency, bankruptcy or reorganization of the Borrower, all such amounts otherwise subject to acceleration under the terms of this Agreement shall nonetheless be payable jointly and severally by the Guarantors hereunder
forthwith on demand by the Lender. 
 Section 2.09. Payments. All payments by any Guarantor to the Lender hereunder
shall be made, without withholding, deduction or offset of any sort, in lawful currency of the United States in immediately available funds at the offices of the Lender at One Kendall Square, Building 700, Cambridge, MA 02139, or such other place as
the Lender may designate. Whenever any payment hereunder shall be due on a day that is not a Business Day, the date for payment thereof shall be extended to the next succeeding Business Day, and any interest payable thereon shall be payable for such
extended time at the specified rate. Any payments received after 2:00 p.m. on any day will be deemed received on the next succeeding Business Day. 
 ARTICLE III 
 REPRESENTATIONS AND WARRANTIES 
 Section 3.01. Representations and Warranties. Each Guarantor hereby represents and warrants that: 
 (a) Each Guarantor (i) is a corporation, duly incorporated, validly existing and in good standing under the laws of the jurisdiction
indicated in the introductory sentence of this Agreement, (ii) has the corporate power and authority to own its assets and to transact the business in which it is now engaged and to enter into and perform this Agreement and each of the other
Guarantors’ Agreements in which such Guarantor is named as a party, and (iii) is duly qualified as a foreign corporation (or company, as the case may be) and in good standing under the laws of each jurisdiction in which failure to be so
qualified could have a material adverse effect on the business, assets or condition of such Guarantor. At the date of this Agreement, no

  

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Guarantor has any Subsidiaries, except as shown on item 3.01(a) of the attached Disclosure Schedule. 
 (b) The owners of all of the equity securities of each Guarantor are set forth on item 3.01(b) of the attached Disclosure Schedule. 
 (c) The execution, delivery and performance by each Guarantor of this Agreement and each of the other Guarantors’ Agreements in which
such Guarantor is named as a party have been duly approved by such Guarantor’s Board of Directors (and, if required, by such Guarantor’s shareholders) and do not and will not: 
 (i) contravene such Guarantor’s charter documents or by-laws; 
 (ii) violate any provision of, or require any filing, registration, consent or approval under, any law, rule, regulation,
order, writ, judgment, injunction, decree, determination or award presently in effect having applicability to such Guarantor; 
 (iii) result in a breach of or constitute a default or require any consent (not heretofore obtained) under any indenture or loan or credit agreement or any other agreement, lease or instrument to which
such Guarantor is a party or by which such Guarantor or any of its properties may be bound or affected; or 
 (iv) result in, or require, the creation or imposition of any lien, security interest or other encumbrance upon or with respect to any of the properties now owned or hereafter acquired by such Guarantor. 
 (d) This Agreement has been duly executed and delivered on behalf of each Guarantor and is the legal, valid and binding joint and several
obligation of the Guarantors, enforceable against the Guarantors in accordance with its terms. Each of the other Guarantors’ Agreements in which any Guarantor is named as a party has been duly executed and delivered on behalf of each such
Guarantor and is the legal, valid and binding obligation of such Guarantor, enforceable against such Guarantor in accordance with its terms. 
 (e) Each Guarantor is an affiliate of the Borrower and wishes to enter into this Agreement in furtherance of its corporate purposes. Each Guarantor has a substantial interest in the continued financial
strength of the Borrower and, in particular, its financing arrangements with the Lender, and the execution and delivery of this Agreement is a substantial inducement for the Lender to enter into the Loan Agreement. Each Guarantor has determined the
execution, delivery and performance of this Agreement to be necessary and convenient to the conduct, promotion and attainment of the businesses of such Guarantor and the Borrower. 
 (f) Except as described on item 3.01(f) of the attached Disclosure Schedule, there are no actions, suits, proceedings or investigations
pending or, to the knowledge of any Guarantor, threatened by or against any Guarantor or any Subsidiary of a Guarantor before any court or governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, which
could hinder or prevent the consummation of the transactions contemplated hereby or call into question the validity of this Agreement or any action taken or to be taken in

  

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connection with the transactions contemplated hereby or which in any single case or in the aggregate might result in any material adverse change in the business, condition, affairs or operations
of any Guarantor or any such Subsidiaries. 
 (g) After giving effect to this Agreement and the transactions contemplated
hereby, each Guarantor (i) is and will be able to pay its debts as they become due, (ii) has and will have funds and capital sufficient to carry on its business as now conducted or as contemplated to be conducted, (iii) owns property
having a value both at fair valuation and at present fair salable value greater than the amount required to pay its debts as they become due, and (iv) is not insolvent and will not be rendered insolvent as determined by applicable law, after
taking into account the reasonable likelihood of payments being required hereunder. 
 ARTICLE IV 
 COVENANTS 
 Section 4.01. Guarantors’ Covenants Effective Regardless of Status of Merger Agreement. Without limitation of any other covenants and agreements contained herein or elsewhere, so long as the Loan Agreement is in effect or
any of the Guaranteed Obligations remain outstanding: 
 (a) Covenants Incorporated by Reference. Each Guarantor
(i) will perform (and will cause each of its Subsidiaries to perform) all affirmative agreements and covenants applicable to it set forth in the Merger Agreement, and (ii) will not violate or suffer or permit the violation of any of the
negative covenants or agreements applicable to it contained in the Merger Agreement by itself or by any of such Guarantor’s Subsidiaries; all of which affirmative and negative covenants and agreements (together with the related definitions
contained in the Merger Agreement) are incorporated herein by this reference as effectively as if set forth at length herein. Said agreements and covenants (and the related definitions) are incorporated herein as they exist in the Merger Agreement
at the date hereof and without regard for any future termination or waiver of the Merger Agreement. 
 (b) Further
Assurances. Each Guarantor will execute and deliver, or cause to be executed and delivered, to the Lender from time to time, promptly upon request therefor, any and all other and further instruments (including correction instruments and
supplemental security documents) that may be reasonably requested by the Lender to cure any deficiency in the execution and delivery of this Agreement or any of the other Guarantors’ Agreements in which such Guarantor is named as a party or
more fully to describe or give effect to particular aspects of any of the agreements and undertakings of such Guarantor provided in this Agreement or any of the other Guarantors’ Agreements or intended to be so provided. 
 Section 4.02 Guarantors’ Covenants Effective Upon Termination of the Merger Agreement. Without limitation of any other
covenants and agreements contained herein or elsewhere, so long as the Loan Agreement is in effect or any of the Guaranteed Obligations remain outstanding, the Guarantors will observe and perform each of the covenants and agreements contained in the
Loan Agreement and relevant to the Guarantors, all such covenants

  

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and agreements of the Loan Agreement (together with the related definitions) being incorporated herein by this reference as effectively as if set forth at length herein. 
 ARTICLE V 
 DEFAULT AND REMEDIES 
 Section 5.01. Events of Default. An Event of Default will be deemed to have
occurred under this Agreement upon the occurrence of any one or more of the following: 
 (i) Any Guarantor shall
fail to make any monetary payment hereunder when due; or 
 (ii) Any representation or warranty of any Guarantor
contained herein or made in connection herewith shall at any time prove to have been incorrect in any material respect when made; or 
 (iii) Any Guarantor shall fail to perform or observe any obligation or agreement under Section 4.01 or Section 4.02 and such failure shall, as to any provision incorporated herein by reference
to the Loan Agreement and/or the Merger Agreement, continue beyond the expiration of the notice and/or grace period (if any) provided for the corresponding provision in the Loan Agreement or the Merger Agreement, as applicable; or 
 (iv) Any Guarantor shall fail to perform or observe any other obligation or agreement contained in this Agreement and such
failure shall continue uncured for ten (10) Business Days after written notice of such failure is given to such Guarantor; or 
 (v) Any default on the part of any Guarantor or any Subsidiary of any Guarantor shall exist, and shall remain unwaived or uncured beyond the expiration of any applicable notice and/or grace period, under
any other contract, agreement or undertaking now existing or hereafter entered into with or for the benefit of the Lender (or any affiliate of the Lender); or 
 (vi) Any default shall exist and remain unwaived or uncured beyond the expiration of any applicable notice and/or grace
period with respect to any other Indebtedness of any Guarantor or any Subsidiary of any Guarantor that would constitute an “Event of Default” under and as defined in the Loan Agreement; or 
 (vii) Any Guarantor, other than Healthcare, shall be dissolved; or any Guarantor or any Subsidiary of any Guarantor shall
become insolvent or bankrupt or shall cease paying its debts as they mature or shall make an assignment for the benefit of creditors; or a trustee, receiver or liquidator shall be appointed for any Guarantor or any Subsidiary of any Guarantor or for
a substantial part of the property of any of the foregoing; or bankruptcy, reorganization, arrangement, insolvency or similar proceedings shall be instituted by or against any Guarantor or any such Subsidiary under the laws of any jurisdiction
(except for an involuntary proceeding filed against any Guarantor or any

  

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Subsidiary of any Guarantor that is dismissed within 60 days following the institution thereof); or 
 (viii) Any final uninsured judgment shall be entered against any Guarantor or any Subsidiary of any Guarantor which would constitute an “Event of Default” under and as defined in the Loan
Agreement; or 
 (ix) Any Guarantor or any Subsidiary of any Guarantor shall fail to meet its minimum funding
requirements under ERISA with respect to any employee benefit plan (or other class of benefit which the PBGC has elected to insure) or any such plan shall be the subject of termination proceedings (whether voluntary or involuntary) and there shall
result from such termination proceedings a liability of any Guarantor or any Subsidiary of any Guarantor to the PBGC which in the reasonable opinion of the Lender may have a material adverse effect upon the financial condition of any Guarantor and
its Subsidiaries, taken as a whole; or 
 (x) An Environmental Event shall have occurred that in the reasonable
opinion of the Lender materially adversely affects the financial condition, prospects, business or operations of any Guarantor or any of its Subsidiaries or any of their respective premises; or 
 (xi) There shall occur any other material adverse change in the condition (financial or otherwise), operations, properties,
assets, liabilities or earnings of any Guarantor and its Subsidiaries, taken as a whole. 
 Section 5.02. Rights and
Remedies Upon Default. Upon the occurrence of any Event of Default and at any time thereafter during the continuance thereof, in addition to any other rights and remedies available to the Lender hereunder or otherwise, the Lender may exercise
any one or more of the following rights and remedies (all of which shall be cumulative): 
 (a) Enforce the provisions of this
Agreement by legal proceedings for the specific performance of any covenant or agreement contained herein or for the enforcement of any other appropriate legal or equitable remedy, and the Lender may recover damages caused by any breach by any
Guarantor of the provisions of this Agreement, including court costs, reasonable attorneys’ fees and other costs and expenses incurred in the enforcement of the obligations of any Guarantor hereunder. 
 (b) Exercise all rights and remedies hereunder, under the Guarantors’ Documents, under the Loan Documents, and under any other
agreement with the Lender, and exercise all other rights and remedies that the Lender may have under applicable law. 
 Section 5.03. Set-off. In addition to any rights now or hereafter granted under applicable law and not by way of limitation of any such rights, upon the occurrence of any Event of Default and during the continuance thereof, the
Lender is hereby authorized at any time or from time to time, without presentment, demand, protest or other notice of any kind to any Guarantor or to any other Person, all of which are hereby expressly waived, to set off and to appropriate and apply

  

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any and all deposits and any other Indebtedness at any time held or owing by the Lender or any affiliate of the Lender to or for the credit or the account of any Guarantor against and on account
of the obligations and liabilities of any Guarantor to the Lender, under this Agreement or otherwise, although said obligations, liabilities or claims, or any of them, may then be contingent or unmatured and without regard for the availability or
adequacy of other collateral. ANY AND ALL RIGHTS TO REQUIRE THE LENDER TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY COLLATERAL WHICH SECURES ANY OF THE OBLIGATIONS PRIOR TO THE EXERCISE BY THE LENDER OF ITS RIGHT OF SET-OFF UNDER THIS
SECTION ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED. 
 Section 5.04. Distribution. All cash actually
received by the Lender pursuant to this Agreement or the exercise of its rights hereunder shall be applied by the Lender in the manner set forth in Section 1.5 of the Loan Agreement. 
 ARTICLE VI 
 MISCELLANEOUS 
 Section 6.01. No Waiver; Cumulative Remedies. No failure or delay on the part of any party in exercising any right, power or
remedy hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any such right, power or remedy preclude any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. The
remedies herein provided are cumulative and not exclusive of any remedies provided by law or otherwise available to the Lender. Such remedies may be exercised without resort or regard to the other source of satisfaction of any liabilities of any
Guarantor to the Lender. The provisions of this Agreement are not limited by nor in limitation of any additional or inconsistent provisions contained in the Loan Agreement or elsewhere. 
 Section 6.02. Amendments, Waivers and Consents. Neither this Agreement nor any provision hereof may be amended, waived
discharged or terminated orally. Any such amendment, waiver, discharge or termination must be in writing signed by the party against whom enforcement of the amendment, waiver, discharge or termination is sought. Any waiver or consent may be given
subject to satisfaction of conditions stated therein and any waiver or consent shall be effective only in the specific instance and for the specific purpose for which given. 
 Section 6.03. Addresses for Notices, etc. Except as otherwise expressly provided in this Agreement, all notices, requests,
demands and other communications provided for hereunder shall be in writing and shall be mailed or delivered to the applicable party at the address indicated below:

  

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 If to the Guarantors: 
 Atossa HealthCare, Inc. 
 MDRNA Research, Inc. 
 Calais Acquisition Corp. 
 c/o MDRNA, Inc. 
 3830 Monte Villa Parkway 
 Bothell, Washington 98021 
 Attention: J. Michael French, President 
 and Chief Executive Officer 
 If to the Lender: 
 Cequent Pharmaceuticals, Inc. 
 One Kendall Square 
 Building 700 
 Cambridge, MA 02139 
 Attention: Peter D. Parker, President 
 and Chief Executive Officer 
 or, as to each of the foregoing, at such other address as shall be designated by such Person in a written notice to the other party complying as to delivery
with the terms of this Section. Except as otherwise provided herein, all such notices, requests, demands and other communications shall be deemed delivered on the earlier of (i) the date received or (ii) the date of delivery, refusal or
non-delivery indicated on the return receipt if deposited in the United States mails, sent postage prepaid, registered or certified mail, return receipt requested, postage and registration or certification charges prepaid, addressed as aforesaid. If
any such notice, request, demand or other communication is hand-delivered or delivered by overnight delivery service, same shall be effective upon receipted delivery. 
 Section 6.04. Costs, Expenses and Taxes. The Guarantors jointly and severally agree to pay all costs and expenses (including, without limitation, reasonable legal fees) incurred by the Lender
in connection with the preparation, execution and delivery of this Agreement and all other instruments and documents to be delivered in connection herewith and any amendments or modifications of any of the foregoing, as well as the costs and
expenses incurred by the Lender in connection with the administration, default, collection, waiver or amendment of any terms of this Agreement and/or such other instruments and documents, or in connection with the Lender’s exercise,
preservation or enforcement of any of its rights, remedies or options hereunder or thereunder, including, without limitation, fees of outside legal counsel or the allocated costs of in-house legal counsel, accounting, consulting, brokerage or other
similar professional fees or expenses, and any fees or expenses associated with travel or other costs relating to any appraisals or examinations conducted in connection with this Agreement or any collateral therefor, all whether or not legal action
is instituted. In addition, the Guarantors shall be jointly and severally obligated to pay any and all stamp and other taxes payable or determined to be payable in connection with the execution and delivery of this Agreement and all other
instruments and documents to be delivered in connection with any Guaranteed Obligation. Any fees, expenses or

  

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other charges that the Lender is entitled to receive from any Guarantor hereunder shall bear interest from the date of any demand for payment until paid at a rate per annum equal to the rate that
would be then applicable to the Loan or that would have been then applicable to the Loan, if the Loan is not then outstanding. 
 Section 6.05. Representations and Warranties. All covenants, agreements, representations and warranties made herein or in any other document delivered by or on behalf of any Guarantor pursuant to or in connection with this
Agreement are material and shall be deemed to have been relied upon by the Lender, notwithstanding any investigation heretofore or hereafter made by the Lender and shall survive the issuance of any Guaranteed Obligations, and shall continue in full
force and effect so long as the Loan Agreement is in effect or any of the Guaranteed Obligations remain outstanding and unpaid or any facility for the making of loans to the Borrower remains in effect. All statements contained in any certificate or
other paper delivered to the Lender at any time by or on behalf of any Guarantor pursuant hereto shall constitute representations and warranties by such Guarantor hereunder. All representations, warranties, covenants, agreements and obligations of
the Guarantors contained herein shall be deemed to be joint and several representations, warranties, covenants and agreements of the Guarantors, whether or not expressly so stated herein. 
 Section 6.06. Binding Effect; Assignment. This Agreement shall be binding upon each Guarantor and its respective successors and
assigns and shall inure to the benefit of the Lender and its successors and assigns. No Guarantor may assign this Agreement or any rights hereunder without the express written consent of the Lender. 
 Section 6.07. Reproduction of Agreement. This Agreement and all other instruments, documents and papers which relate thereto
that have been or may be hereafter furnished to the Lender may be reproduced by the Lender by any photographic, photostatic, micro-card, miniature photographic, xerographic or similar process, and the Lender may destroy the original from which any
document was so reproduced. Any such reproduction shall be admissible in evidence as the original itself in any judicial or administrative proceeding (whether or not the original is in existence and whether or not such reproduction was made in the
regular course of business). 
 Section 6.08. Replacement Documents. Upon receipt of an affidavit of an officer of
the Lender as to the loss, theft, destruction or mutilation of this Agreement or of any other document delivered pursuant hereto that is not of public record and, in the case of any such mutilation, upon surrender and cancellation of this Agreement
or such other document, the Guarantors will issue, in lieu thereof, a replacement Guaranty Agreement or other document. 
 Section 6.09. Consent to Jurisdiction. Each Guarantor irrevocably submits to the non-exclusive jurisdiction of any Massachusetts court or any federal court sitting within The Commonwealth of Massachusetts over any suit, action
or proceeding arising out of or relating to this Agreement. Each Guarantor irrevocably waives, to the fullest extent permitted by law, any objection which it may now or hereafter have to the laying of venue of any such suit, action or proceeding
brought in such a court and any claim that any such suit, action or proceeding has been brought in an inconvenient forum. Each Guarantor agrees that final judgment in any such suit, action or proceeding brought in such a court shall be enforced in
any court of proper

  

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jurisdiction by a suit upon such judgment, provided that service of process in such action, suit or proceeding shall have been effected upon such Guarantor in one of the manners specified in the
following paragraph of this Section 6.09 or as otherwise permitted by law. 
 Each Guarantor hereby consents to process
being served in any suit, action or proceeding of the nature referred to in the preceding paragraph of this Section 6.09 either (i) by mailing a copy thereof by registered or certified mail, postage prepaid, return receipt requested, to it
at its address set forth in Section 6.03 or (ii) by serving a copy thereof upon it at its address set forth in Section 6.03. Each Guarantor irrevocably waives, to the fullest extent permitted by law, all claims of error by reason of
any service as contemplated herein and agrees that such service shall (x) be deemed in every respect effective service upon such Guarantor in any such suit, action or proceeding and (y) to the fullest extent permitted by law, be taken and
held to be valid personal service upon and personal delivery to such Guarantor. 
 Section 6.10. Governing Law. This
Agreement shall be governed by, and construed in accordance with, the laws of The Commonwealth of Massachusetts (without giving effect to conflict of laws principles). 
 Section 6.11. Severability. In the event that any provision of this Agreement or the application thereof to any Person, property or circumstances shall be held to any extent to be invalid or
unenforceable, the remainder of this Agreement and the application of such provision to Persons, properties or circumstances other than those as to which it has been held invalid or unenforceable shall not be affected thereby, and each provision of
this Agreement shall be valid and enforceable to the fullest extent permitted by law. 
 Section 6.12. Usury. It is
expressly stipulated and agreed to be the intent of each Guarantor and the Lender at all times to comply with applicable state law or applicable United States federal law (to the extent that it permits the Lender to contract for, charge, take,
reserve or receive a greater amount of interest than under state law) and that this Section shall control every other covenant and agreement in this Agreement and the other Loan Documents. If applicable state or federal law should be at any time be
judicially interpreted so as to render usurious any amount called for under this Agreement, or any of the other Loan Documents, or contracted for, charged, taken, reserved or received with respect to this Agreement, or if the acceleration of any
Guaranteed Obligation, or any prepayment, results in any Guarantor having paid any interest in excess of that permitted by applicable law, then it is the Lender’s express intent that all excess amounts theretofore actually collected by the
Lender from such Guarantor and then retained by the Lender shall be credited on the principal balance of the indebtedness guaranteed hereby, and the provisions of this Agreement shall immediately be deemed reformed and the amounts thereafter
collectible hereunder and thereunder reduced, without the necessity of the execution of any new documents, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder or thereunder.
All sums paid or agreed to be paid by any Guarantor to the Lender for the use or forbearance of the Guaranteed Obligations shall, to the extent permitted by applicable law, be amortized, prorated, allocated and spread throughout the full stated term
of the Guaranteed Obligations until payment in full so that the rate or amount of interest collected under this Agreement does not exceed the maximum lawful rate from time to time in effect and applicable to the obligations payable under this
Agreement. 
  

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 Section 6.13. Headings. Article and Section headings in this Agreement are
included herein for convenience of reference only and shall not constitute a part of this Agreement for any other purpose. 
 Section 6.14. WAIVER OF JURY TRIAL. THE GUARANTORS AND THE LENDER WAIVE TRIAL BY JURY IN RESPECT OF ANY DISPUTE OR CLAIM HEREUNDER OR UNDER ANY OF THE OTHER LOAN DOCUMENTS AND ANY ACTION ON SUCH DISPUTE. THIS WAIVER IS
KNOWINGLY, WILLINGLY AND VOLUNTARILY MADE BY THE GUARANTORS AND THE LENDER, AND THE GUARANTORS AND THE LENDER HEREBY REPRESENT THAT NO REPRESENTATIONS OF FACT OR OPINION HAVE BEEN MADE BY ANY PERSON OR ENTITY TO INDUCE THIS WAIVER OF TRIAL BY JURY
OR TO IN ANY WAY MODIFY OR NULLIFY ITS EFFECT. THIS PROVISION IS A MATERIAL INDUCEMENT FOR THE PARTIES ENTERING INTO THE LOAN DOCUMENTS. THE GUARANTORS AND THE LENDER ARE EACH HEREBY AUTHORIZED TO FILE A COPY OF THIS SECTION IN ANY PROCEEDING AS
CONCLUSIVE EVIDENCE OF THIS WAIVER OF JURY TRIAL. EACH GUARANTOR FURTHER REPRESENTS AND WARRANTS THAT IT HAS BEEN REPRESENTED IN THE SIGNING OF THIS AGREEMENT AND IN THE MAKING OF THIS WAIVER BY INDEPENDENT LEGAL COUNSEL, OR HAS HAD THE OPPORTUNITY
TO BE REPRESENTED BY INDEPENDENT LEGAL COUNSEL SELECTED OF ITS OWN FREE WILL, AND THAT IT HAS HAD THE OPPORTUNITY TO DISCUSS THIS WAIVER WITH COUNSEL. 
 Section 6.15. Integration. This Agreement and any other documents delivered herewith are intended by the parties as the final, complete and exclusive statement of the transactions evidenced by
this Agreement. All prior or contemporaneous promises, agreements and understandings, whether oral or written, are deemed to be superseded by this Agreement and the other documents delivered herewith. 
 Section 6.16. Counterparts. This Agreement may be signed in any number of counterparts with the same effect as if the signatures
hereto and thereto were upon the same instrument. 
 [Signature pages follow.] 
  

 - 15 - 

 IN WITNESS WHEREOF, the Guarantors have executed this Agreement, as an instrument under
seal, as of the day and year first above written. 
  

			
	ATOSSA HEALTHCARE, INC.
		
	By:	 	 /s/ J. Michael French

	Name:	 	J. Michael French
	Title:	 	President
	
	MDRNA RESEARCH, INC.
		
	By:	 	 /s/ J. Michael French

	Name:	 	J. Michael French
	Title:	 	President
	
	CALAIS ACQUISITION CORP.
		
	By:	 	 /s/ J. Michael French

	Name:	 	J. Michael French
	Title:	 	President

 Signature Page to Guaranty
Agreement 

 Accepted: 
  

			
	CEQUENT PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Peter D. Parker

	Name:	 	Peter D. Parker
	Title:	 	President and Chief Executive Officer

 Signature Page to Guaranty Agreement 

 DISCLOSURE SCHEDULE 
  

			
	Item 3.01(a)	 	- Subsidiaries of Guarantors
		
	Item 3.01(b)	 	- Ownership of Stock of Guarantors
		
	Item 3.01(f)	 	- Litigation and Administrative Proceedings

 Item 3.01(a) 
 Subsidiaries of Guarantors 
 None 

 Item 3.01(b) 
 Ownership of Stock of Guarantors 
  

								
	 Guarantor:
	  	 Stockholder:
	  	 Number of Shares/Class:
	  	Percent
Ownership:	 
	Atossa HealthCare, Inc.	  	MDRNA, Inc.	  	100 / Common	  	100	% 
	MDRNA Research, Inc.	  	MDRNA, Inc.	  	360,000 / Common	  	100	% 
		  	MDRNA, Inc.	  	1,839,080 / Series A Participating Preferred	  	100	% 
	Calais Acquisition Corp.	  	MDRNA, Inc.	  	1,000 / Common	  	100	% 

 Item 3.01(f) 
 Litigation and Administrative Proceedings 
 None

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