Document:

<PAGE>

                           CONSENT AND AMENDMENT NO. 4

     THIS CONSENT AND AMENDMENT NO. 4, dated as of September [ ], 2006 ("Consent
and Amendment No. 4") among PolyMedica Corporation, a Massachusetts corporation
(the "Borrower"), the lenders from time to time parties thereto (collectively,
the "Lenders"), and Bank of America, N.A., as administrative agent (in such
capacity, the "Administrative Agent") to the Credit Agreement, dated as of April
12, 2005, as supplemented, amended and modified by the Credit Agreement
Supplement and Amendment, dated as of May 24, 2005, Amendment and Limited Waiver
No. 2, dated as of November 18, 2005, Consent, dated as of February 8, 2006 and
Credit Agreement Supplement and Amendment No. 3, dated as of March 30, 2006 (the
"Credit Agreement") among the Borrower, the Lenders, the Administrative Agent,
Swing Line Lender and L/C Issuer and certain other agents parties thereto.
Capitalized terms used and not otherwise defined herein shall have the meanings
assigned to such terms in the Credit Agreement (the Credit Agreement, as amended
by, and together with, this Consent and Amendment No. 4, and as hereinafter
amended, modified, extended or restated from time to time, being called the
"Amended Agreement").

                              W I T N E S S E T H:

     WHEREAS, the Borrower has requested certain amendments to its existing
financial covenants and other covenants under the Credit Agreement;

     WHEREAS, the Borrower has requested the Required Lenders consent to the
terms of an issuance of certain convertible subordinated notes of the Borrower,
the terms of which are set forth on Annex A hereto (the "Convertible
Subordinated Notes"); and

     WHEREAS, the parties hereto have agreed, subject to the terms and
conditions hereof, to supplement, amend and modify the Credit Agreement as
provided herein and to consent to the terms of the Convertible Subordinated
Notes;

     NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto hereby agree as
follows:

                                   ARTICLE I
                                   AMENDMENTS

     Effective as of the Consent and Amendment Effective Date (defined below),
the Credit Agreement is hereby amended as follows:

     1.01 AMENDMENTS TO SECTION 1.01. (a) Section 1.01 is hereby amended by
adding the following definitions in the appropriate alphabetical order:

          ""Consolidated Senior Indebtedness" means, for the Borrower and its
          Subsidiaries determined on a consolidated basis, as of any date of
          determination, without duplication, total Indebtedness as of such date
          minus the aggregate principal amount of any Permitted Subordinated
          Indebtedness outstanding on such date (including any obligations
          arising from a permitted refinancing thereof)."

          ""Consolidated Senior Leverage Ratio" means, as of any date of
          determination, the ratio of (a) Consolidated Senior Indebtedness as of
          such date to (b) Consolidated EBITDA for the period of the four
          consecutive fiscal quarters most recently ended."

<PAGE>

          ""Convertible Subordinated Notes" means the Convertible Subordinated
          Notes due September 2011 in an original aggregate principal amount not
          to exceed $180 million."

          ""Fourth Consent and Amendment Effective Date" means September [ ],
          2006."

     (b) Section 1.01 is hereby amended by deleting the following definitions in
their entirety and replacing them with the following:

          ""Applicable Rate" means, from time to time, the following percentages
     per annum, based upon the Consolidated Senior Leverage Ratio as set forth
     in the most recent Compliance Certificate received by the Administrative
     Agent pursuant to Section 6.02(b):

<TABLE>
<CAPTION>

                                      APPLICABLE RATE

                  REVOLVING LOANS, SWING LINE LOANS AND LETTERS OF CREDIT
--------------------------------------------------------------------------------------------

                   Consolidated                              Base Rate
                     Senior             Eurodollar           Loans and
    Pricing         Leverage          Rate Loans and        Swing Line        Commitment
     Level            Ratio          Letters of Credit         Loans             Fees
--------------------------------------------------------------------------------------------
<S>              <C>               <C>                   <C>               <C>

       I         > 2.50 to 1.00           1.75%               0.50%             0.25%

--------------------------------------------------------------------------------------------

      II         >2.00 to 1.00            1.50%               0.25%             0.20%
                 but
                 < 2.50 to 1.00
                 -

--------------------------------------------------------------------------------------------

      III        >1.50 to 1.00            1.25%                 0               0.20%
                 but
                 < 2.00 to 1.00
                 -

--------------------------------------------------------------------------------------------

      IV         >1.00 to 1.00            1.00%                 0               0.15%
                 but
                 < 1.50 to 1.00
                 -

--------------------------------------------------------------------------------------------

       V         <1.00 to 1.00            0.75%                 0               0.15%
                 -

============================================================================================
</TABLE>

          Any increase or decrease in the Applicable Rate resulting from a
     change in the Consolidated Senior Leverage Ratio shall become effective as
     of the first Business Day immediately following the date a Compliance
     Certificate is delivered pursuant to Section 6.02(b); provided, however,
     that if a Compliance Certificate is not delivered when due in accordance
     with such Section 6.02(b), then, at the option of the Required Lenders,
     Pricing Level I will be applicable until the first Business Day immediately
     following the date an appropriate Compliance Certificate is delivered,
     whereupon the Applicable Rate shall be adjusted based on the information
     contained in the Compliance Certificate. The Applicable Rate in effect
     during the period from the Fourth Consent and Amendment

                                       2
<PAGE>

     Effective Date until the next quarterly Compliance Certificate is delivered
     shall be determined based upon Pricing Level II."

     (c) Section 1.01 is hereby amended by changing the defined term
"Consolidated Leverage Ratio" to "Consolidated Total Leverage Ratio", and
realphabetizing such term in proper order. The reference to the defined term
"Consolidated Leverage Ratio" in Section 4.01(a)(ix) is hereby changed to
"Consolidated Total Leverage Ratio".

     1.02 AMENDMENTS TO CERTAIN COVENANTS IN ARTICLE VII. (a) Section 7.03 is
hereby amended by deleting subsection (g) thereof in its entirety and replacing
it with the following:

               "(g) so long as no Default has occurred and is continuing or
          would result therefrom, Permitted Subordinated Indebtedness in an
          aggregate amount not to exceed $200 million at any one time
          outstanding; and"

     (b) Section 7.06 is hereby amended by deleting "and" after subsection (d),
adding "; and" after subsection (e) and deleting "." at the end of subsection
(e), and by adding immediately following subsection (e) thereof, a new
subsection (f) as follows:

               "(f) the Borrower may permit the conversion of the Convertible
          Subordinated Notes in accordance with the terms of the Convertible
          Subordinated Notes, and in connection therewith the Borrower may
          purchase options sufficient to satisfy any such conversions and
          exercise options to purchase or sell its common Equity Interests upon
          any such conversions."

     1.03 AMENDMENTS TO FINANCIAL COVENANTS IN ARTICLE VII. (a) Section 7.15 of
the Credit Agreement is hereby amended by deleting subsection (b) thereof in its
entirety and replacing such subsection with the following:

               "(b) Consolidated Coverage Ratio. Permit the Consolidated
          Coverage Ratio as of the end of any fiscal quarter of the Borrower to
          be less than 2.75 to 1.00."

     (c) Section 7.15 of the Credit Agreement is hereby amended by deleting
subsection (c) thereof in its entirety and replacing such subsection with the
following:

               "(c) Consolidated Total Leverage Ratio. Permit the Consolidated
          Total Leverage Ratio as of the end of any fiscal quarter (calculated
          for each four consecutive fiscal quarter period) of the Borrower to be
          greater than the ratio set forth opposite such period:

<TABLE>
<CAPTION>

       Four Fiscal                          Maximum Consolidated Total
     Quarters Ending                              Leverage Ratio
     ---------------                              --------------
<S>                                        <C>
Closing Date through
December 31, 2006                                  4.25 to 1.00

March 31, 2007 and each                            4.00 to 1.00"
fiscal quarter thereafter

</TABLE>

                                       3

<PAGE>

     1.04 NEW CONSOLIDATED SENIOR LEVERAGE RATIO FINANCIAL COVENANT IN ARTICLE
VII. Section 7.15 of the Credit Agreement is hereby amended by adding
immediately following subsection (c) thereof a new subsection (d) as follows:

               "(d) Consolidated Senior Leverage Ratio. Permit the Consolidated
          Senior Leverage Ratio as of the end of any fiscal quarter (calculated
          for each four consecutive fiscal quarter period) of the Borrower to be
          greater than the ratio set forth opposite such period:

<TABLE>
<CAPTION>

         Four Fiscal                      Maximum Consolidated
       Quarters Ending                    Senior Leverage Ratio
       ---------------                    ---------------------
<S>                                   <C>
Closing Date through                          2.75 to 1.00
December 31, 2006

March 31, 2007 and each                       2.50 to 1.00"
fiscal quarter thereafter

</TABLE>

     1.05 AMENDMENT TO ARTICLE SECTION 10.6. Section 10.06(b)(iv) of the Credit
Agreement is hereby amended by deleting such subsection in its entirety and
replacing it with the following:

               "(iv) Assignment and Assumption. The parties to each assignment
          shall execute and deliver to the Administrative Agent an Assignment
          and Assumption, together with a processing and recordation fee in the
          amount of $3,500; provided, however, that the Administrative Agent
          may, in its sole discretion, elect to waive such processing and
          recordation fee in the case of any assignment. The assignee, if it is
          not a Lender, shall deliver to the Administrative Agent an
          Administrative Questionnaire."

     1.06 DELETION OF SCHEDULE 10.6. Schedule 10.6 to the Credit Agreement is
hereby deleted in its entirety.

     1.07 REPLACEMENT OF EXHIBIT D. Exhibit D to the Credit Agreement is hereby
replaced in its entirety by Exhibit D attached hereto as Annex B.

                                   ARTICLE II
                             CONSENTS AND AGREEMENTS

     2.01 CONSENT TO PERMITTED SUBORDINATED INDEBTEDNESS. Effective as of the
Consent and Amendment Effective Date, the undersigned hereby consent to the
terms of the Convertible Subordinated Notes and agree that the Convertible
Subordinated Notes constitute Permitted Subordinated Indebtedness. This consent
shall not, by implication or otherwise, constitute an amendment to the terms of
the definition of "Permitted Subordinated Indebtedness" nor shall it constitute
a consent not to comply with any other provision in the Credit Agreement related
to Permitted Subordinated Indebtedness or otherwise.

                                       4

<PAGE>

                                  ARTICLE III
                         REPRESENTATIONS AND WARRANTIES

     3.01 REPRESENTATIONS AND WARRANTIES. The Borrower hereby represents and
warrants to the Administrative Agent and the Lenders, as follows:

     (a) The representations and warranties of the Borrower contained in Article
V of the Amended Agreement, and in each other Loan Document or which are
contained in any document furnished at any time under or in connection
therewith, are true and correct in all material respects on and as of the date
hereof and on and as of the Consent and Amendment Effective Date with the same
effect as if made on and as of the date hereof or the Consent and Amendment
Effective Date, as the case may be, (i) except to the extent such
representations and warranties specifically refer to an earlier date, in which
case they are true and correct in all material respects as of such earlier date,
(ii) except the representations and warranties contained in subsections (a) and
(b) of Section 5.05 of the Amended Agreement shall be deemed to refer to the
most recent financial statements furnished pursuant to subsections (a) and (b),
respectively, of Section 6.01 of the Amended Agreement, and (iii) together with
any additional items that will be disclosed on any updated Schedules required to
be supplemented pursuant to Section 6.02(b) on the next scheduled delivery date,
as to which the Borrower has notified the Administrative Agent in writing.

     (b) After giving effect to this Consent and Amendment No. 4, no Default or
Event of Default has occurred or is continuing under the Amended Agreement.

     (c) The execution, delivery and performance by the Borrower of this Consent
and Amendment No. 4 have been duly authorized by all necessary corporate or
other organizational action of the Borrower.

     (d) No approval, consent, exemption or other action by, or notice to, or
filing with any Governmental Authority or any other Person is necessary or
required in connection with the execution, delivery or performance by the
Borrower or any other Loan Party of this Consent and Amendment No. 4 or any
document related hereto other than the approvals, consents, exemptions, actions,
notices or filings which have been duly obtained, taken, given or made and are
in full force and effect.

     (e) This Consent and Amendment No. 4 constitutes the legal, valid and
binding obligation of the Borrower, enforceable against the Borrower in
accordance with its terms except as such enforceability may be limited by Debtor
Relief Laws and by principles of equity.

     (f) The execution, delivery, performance and compliance with the terms and
provisions, by the Borrower, of this Consent and Amendment No. 4, and the
consummation of the transactions contemplated hereby with respect to each Loan
Party, do not and will not: (i) contravene the terms of any of such Person's
Organization Documents; (ii) conflict with or result in any breach or
contravention of, or the creation of any Lien under, or require any payment to
be made under (A) any Contractual Obligation to which such Person is a party
affecting such Person or the properties of such Person or any of its
Subsidiaries or (B) any order, injunction, writ or decree of any Governmental
Authority or any arbitral award to which such Person or its property is subject;
or (iii) violate any Law, including, without limitation, Medicare Regulations.

                                       5

<PAGE>

                                   ARTICLE IV
                              CONDITIONS PRECEDENT

     4.01 CONDITIONS TO EFFECTIVENESS. This Consent and Amendment No. 4 shall
become effective only upon satisfaction of the following conditions precedent
(the first date upon which each such condition has been satisfied being herein
called the "Fourth Consent and Amendment Effective Date"):

     (a) the Administrative Agent shall have received duly executed counterparts
of this Consent and Amendment No. 4 which, when taken together, bear the
authorized signatures of the Borrower, all of the Lenders and the Administrative
Agent;

     (b) the representations and warranties set forth in Section 3.01 hereof are
true and correct in all material respects on and as of the Fourth Consent and
Amendment Effective Date;

     (c) the Administrative Agent shall have received a Responsible Officer's
Certificate executed by a Responsible Officer of the Borrower in the form of
Annex C hereto;

     (d) all corporate and other proceedings taken or to be taken in connection
with this Consent and Amendment No. 4 and all documents incidental thereto,
whether or not referred to herein, shall be reasonably satisfactory in form and
substance to the Lenders and their respective counsel; and

     (e) the Administrative Agent shall have received payment of all fees and
expenses referred to in Section 5.05.

                                   ARTICLE V
                                  MISCELLANEOUS

     5.01 LENDER CONSENT. For purposes of determining compliance with the
conditions specified in Section 4.01, each Lender that has signed this Consent
and Amendment No. 4 shall be deemed to have consented to, approved or accepted
or to be satisfied with, each document or other matter required thereunder to be
consented to or approved by or acceptable or satisfactory to a Lender unless the
Administrative Agent shall have received notice from such Lender prior to the
Fourth Consent and Amendment Effective Date specifying its objection thereto.

     5.02 APPLICABLE LAW. THIS CONSENT AND AMENDMENT NO. 4 SHALL BE GOVERNED BY,
AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

     5.03 COUNTERPARTS. This Consent and Amendment No. 4 may be executed in any
number of counterparts, each of which shall constitute an original but all of
which when taken together shall constitute but one agreement. Delivery by
facsimile by any of the parties hereto of an executed counterpart of this
Consent and Amendment No. 4 shall be as effective as an original executed
counterpart hereof and shall be deemed a representation that an original
executed counterpart hereof will be delivered, but the failure to deliver a
manually executed counterpart shall not affect the validity, enforceability or
binding effect of this Consent and Amendment No. 4.

     5.04 CREDIT AGREEMENT. Except as expressly set forth herein, the amendments
provided herein shall not by implication or otherwise limit, constitute a waiver
of, or otherwise affect the rights and remedies of the Lenders or the
Administrative Agent under the Amended Agreement or any other Loan Document, nor
shall they constitute a waiver of any Default or Event of Default, nor shall
they alter,

                                       6

<PAGE>

modify, amend or in any way affect any of the terms, conditions, obligations,
covenants or agreements contained in the Amended Agreement or any other Loan
Document. Each of the consent and amendments provided herein shall apply and be
effective only with respect to the provisions of the Amended Agreement
specifically referred to by such consent or amendment. Except as expressly
amended herein, the Amended Agreement shall continue in full force and effect in
accordance with the provisions thereof. As used in the Amended Agreement, the
terms "Agreement", "herein", "hereinafter", "hereunder", "hereto" and words of
similar import shall mean, from and after the date hereof, the Amended
Agreement.

     5.05 COSTS AND EXPENSES. (a) The Administrative Agent shall have received
payment for the account of each Lender which has executed a counterpart of this
Consent and Amendment No. 4 on or prior to the Fourth Consent and Amendment
Effective Date, a fee equal to 0.10% of the Commitment of such Lender.

     (b) On the Fourth Consent and Amendment Effective Date, the Borrower agrees
to pay all reasonable costs and expenses of the Administrative Agent in
connection with the preparation, execution and delivery of this Consent and
Amendment No. 4 and the instruments and documents to be delivered hereunder and
the reasonable fees, charges and expenses of counsel for the Administrative
Agent outstanding on the Fourth Consent and Amendment Effective Date.

     5.06 SECTION CAPTIONS. Section captions used in this Consent and Amendment
No. 4 are for convenience of reference only and shall not affect this
construction of this Consent and Amendment No. 4.

                            [Signature Pages Follow]

                                       7

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Consent and
Amendment No. 4 to be duly executed by their duly authorized officers, all as of
the date first above written.

                                      POLYMEDICA CORPORATION

                                      By:
                                         ---------------------------------------

                                         Name:
                                              ----------------------------------

                                         Title:
                                               ---------------------------------

<PAGE>

                                      BANK OF AMERICA, N.A., as
                                      Administrative Agent

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      BANK OF AMERICA, N.A., as Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

<PAGE>

                                      WACHOVIA BANK, NATIONAL ASSOCIATION,
                                      as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      CITIZENS BANK OF MASSACHUSETTS, as a
                                      Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      KEYBANK NATIONAL ASSOCIATION, as a
                                      Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      CIBC INC., as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

<PAGE>

                                      SUNTRUST BANK, as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      DEUTSCHE BANK TRUST COMPANY
                                      AMERICAS, as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      UBS LOAN FINANCE LLC, as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

<PAGE>

                                      BANKNORTH (TD BANKNORTH), as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      FIFTH THIRD BANK, as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

                                      LASALLE BANK NATIONAL ASSOCIATION,
                                      as a Lender

                                      By:
                                         ---------------------------------------

                                          Name:
                                               ---------------------------------

                                          Title:
                                                --------------------------------

<PAGE>

                                                                      ANNEX A TO
                                                     CONSENT AND AMENDMENT NO. 4

                SUMMARY TERMS FOR CONVERTIBLE SUBORDINATED NOTES

<TABLE>
<S>                                               <C>

Issuer........................................    PolyMedica Corporation

Proceeds / par amount.........................    $150.0 million

Greenshoe.....................................    $30.0 million (20% of base deal size)

Maturity......................................    5 years (September 15, 2011)

Ranking.......................................    Subordinated

Interest......................................    Anticipated to be between 1.0 and 1.5% per year, payable
                                                  semiannually in arrears

Conversion premium............................    Anticipated to be between 10 and 14%

Conversion settlement.........................    Net share settlement.  Upon conversion, a holder will receive

                                                  - Cash equal to the lesser of the conversion value and the
                                                    par amount; and

                                                  - To the extent the conversion value exceeds the par
                                                    amount, shares of PLMD stock with value equal to such excess

Optional redemption...........................    Non-call life

Investor puts.................................    None, except upon a fundamental change

Use of proceeds...............................    The net proceeds of the offering is expected to be $145 million
                                                  (assuming no exercise of the greenshoe).  PolyMedica intends to
                                                  use:

                                                  - $[93] million for the repayment of the credit facility;

                                                  - $[29] million for the purchase of 700,000 shares
                                                     concurrently with the offering; and

                                                  - $[23] million for the purchase of a hedging transaction
                                                     to limit the dilution under the notes
</TABLE>

<PAGE>

                                                                      ANNEX B TO
                                                     CONSENT AND AMENDMENT NO. 4

                                                   EXHIBIT D TO CREDIT AGREEMENT

                         FORM OF COMPLIANCE CERTIFICATE

                                      Financial Statement Date:              ,
                                                               --------------

To: Bank of America, N.A., as Administrative Agent

Ladies and Gentlemen:

     Reference is made to that certain Credit Agreement, dated as of April 12,
2005 (as amended, restated, amended and restated, extended, supplemented or
otherwise modified in writing from time to time, the "Agreement;" the terms
defined therein being used herein as therein defined), among PolyMedica
Corporation, a Massachusetts corporation (the "Borrower"), the Lenders from time
to time party thereto, Bank of America, N.A., as Administrative Agent, L/C
Issuer and Swing Line Lender and certain other agents party thereto.

     The undersigned Responsible Officer hereby certifies, in [his/her] capacity
as such and not individually, as of the date hereof that he/she is the
        of the Borrower, and that, as such, he/she is authorized to execute and
deliver this Certificate to the Administrative Agent on the behalf of the
Borrower, and that:

      [Use following paragraph 1 for fiscal YEAR-END financial statements]

     1. Attached hereto as Schedule 1 are the year-end audited financial
statements required by Section 6.01(a) of the Agreement for the fiscal year of
the Borrower ended as of the above date, together with the report and opinion of
an independent certified public accountant required by such section.

     [Use following paragraph 1 for fiscal QUARTER-END financial statements]

     1. Attached hereto as Schedule 1 are the unaudited financial statements
required by Section 6.01(b) of the Agreement for the fiscal quarter of the
Borrower ended as of the above date. Such financial statements fairly present in
all material respects the financial condition, results of operations and cash
flows of the Borrower and its Subsidiaries in accordance with GAAP as at such
date and for such period, subject only to normal year-end audit adjustments and
the absence of footnotes.

     2. The undersigned has reviewed and is familiar with the terms of the
Agreement and has made, or has caused to be made under his/her supervision, a
review of the activities of the Borrower during the accounting period covered by
the attached financial statements.

     3. A review of the activities of the Borrower and each Loan Party during
such fiscal period has been made under the supervision of the undersigned with a
view to determining whether

<PAGE>

during such fiscal period the Borrower and each Loan Party performed and
observed all their respective Obligations under the Loan Documents, and

                                  [SELECT ONE:]

     [TO THE KNOWLEDGE OF THE UNDERSIGNED DURING SUCH FISCAL PERIOD, EACH OF THE
BORROWER AND THE OTHER LOAN PARTIES PERFORMED AND OBSERVED EACH COVENANT AND
CONDITION OF THE LOAN DOCUMENTS APPLICABLE TO IT, AND NO DEFAULT HAS OCCURRED
AND IS CONTINUING.]

                                     --OR--

     [THE FOLLOWING COVENANTS OR CONDITIONS HAVE NOT BEEN PERFORMED OR OBSERVED
AND THE FOLLOWING IS A LIST OF EACH SUCH DEFAULT AND ITS NATURE AND STATUS:]

     4. The representations and warranties of the Borrower contained in Article
V of the Agreement, or which are contained in any document furnished at any time
under or in connection with the Loan Documents, are true and correct in all
material respects on and as of the date hereof, except to the extent that such
representations and warranties specifically refer to an earlier date, in which
case they are true and correct in all material respects as of such earlier date,
and except that for purposes of this Compliance Certificate, the representations
and warranties contained in subsections (a) and (b) of Section 5.05 of the
Agreement shall be deemed to refer to the most recent statements furnished
pursuant to clauses (a) and (b), respectively, of Section 6.01 of the Agreement,
including the statements in connection with which this Compliance Certificate is
delivered.

     5. The financial covenant analyses and information set forth on Schedule 2
attached hereto are true and accurate in all material respects on and as of the
date of this Certificate.

     IN WITNESS WHEREOF, the undersigned has executed this Certificate as of
___________________, _________.

                                      POLYMEDICA CORPORATION

                                      By:
                                         ---------------------------------------

                                      Name:
                                           -------------------------------------

                                      Title:
                                            ------------------------------------

<PAGE>

                For the Quarter/Year ended ___________________("Statement Date")

                                   SCHEDULE 2
                          to the Compliance Certificate
                                  ($ in 000's)

                           [see Attached Spreadsheet]

<PAGE>
                             POLYMEDICA CORPORATION
                             Compliance Certificate
                  Per the Credit Agreement dated April 12, 2005
                          (as amended and supplemented)

<TABLE>
<S>                                                                             <C>                      <C>

CONSOLIDATED NET WORTH

A. Beginning Net Worth (from line E of the previous quarter)
                                                                                                         ---------
B.   PLUS:                           75% of Net Income each Quarter             +
                                                                                 -----------------------
                                     100% increases in Shareholders' Equity     +                      0
                                                                                 -----------------------
C.   LESS:                           Dividends and Stock Repurchase             -
                                                                                 -----------------------
D.   Sub-total (lines B less line C)                                                                            $0
                                                                                                         ---------
E. Ending Consolidated Net Worth for Covenant Compliance (line A less line D)                                   $0
                                                                                                         =========
F. Actual Consolidated Net Worth (shareholder's equity from the balance sheet)
                                                                                                         ---------

CONSOLIDATED COVERAGE RATIO

A.   Consolidated Net Income
                                                                                                         ---------
B.   PLUS:                           Consolidated Interest Charges              +
                                                                                 -----------------------
                                     Taxes                                      +
                                                                                 -----------------------
                                     Depreciation                               +
                                                                                 -----------------------
                                     Amortization (excluding direct-advertising)+
                                                                                 -----------------------
                                     Settlement Charges (< $30 million)         +
                                                         -                       -----------------------
                                     Non-cash Stock-based Compensation Charge   +
                                                                                 -----------------------
                                     Other One-time Non-cash Charges            +
                                                                                 -----------------------
                                     One-time Cash Charges                      +
                                                                                 -----------------------
C.   LESS:                           Tax Credits                                -
                                                                                 -----------------------
                                     Extraordinary Gains                        -
                                                                                 -----------------------
                                     Non-cash Items Increasing Net Income       -
                                                                                 -----------------------
D.   Sub-total (lines B less lines C)                                                                           $0
                                                                                                         ---------
E.   Consolidated EBITDA (line A plus line D) (used for leverage calculation)                                   $0
                                                                                                         ---------
F.   PLUS:                           Direct-advertising Amortization            +
                                                                                 -----------------------
G.   LESS:                           Direct-advertising Expense                 -
                                                                                 -----------------------
H. Adjusted Consolidated EBITDA (line E plus line F less line G)                                                $0
                                                                                                         =========

I.                                   Consolidated Interest Charges              +                      0
                                                                                 -----------------------
J.   PLUS:                           Consolidated Cash Dividends                +
                                                                                 -----------------------
K. Total Coverage Charges (line I plus line J)                                                                  $0
                                                                                                         =========

                                                                                RATIO (LINE H/LINE K)
                                                                                                         ---------
                                                                                  Covenant:                >
                                                                                                           _ _.__
</TABLE>

<PAGE>

<TABLE>
<S>                                                                               <C>

CONSOLIDATED TOTAL LEVERAGE RATIO

A. Consolidated Funded Indebtedness
                                                                                                        ==========

B. Consolidated EBITDA (line E above)                                                                           $0
                                                                                                        ==========

                                                                                RATIO (LINE A/LINE B)
                                                                                                        ----------
                                                                                  Covenant                < _.__

CONSOLIDATED SENIOR LEVERAGE RATIO

A. Consolidated Senior Indebtedness
                                                                                                        ==========

B. Consolidated EBITDA (line E above)                                                                           $0
                                                                                                        ==========

                                                                                RATIO (LINE A/LINE B)
                                                                                                        ----------
                                                                                  Covenant                < _.__

</TABLE>

<PAGE>

                                                                      ANNEX C TO
                                                     CONSENT AND AMENDMENT NO. 4

                        RESPONSIBLE OFFICER'S CERTIFICATE

                             POLYMEDICA CORPORATION

     The undersigned duly appointed and acting Responsible Officer of PolyMedica
Corporation, a Massachusetts corporation (the "Borrower"), in connection with
Consent and Amendment No. 4, dated as of September 8, 2006 ("Consent and
Amendment No. 4"), amending, supplementing and modifying certain provisions of
the Credit Agreement dated as of April 12, 2005 (as so amended and supplemented
on May 24, 2005, November 18, 2005, the subject of a Consent dated as of
February 8, 2006 and amended and supplemented on March 30, 2006 (the "Credit
Agreement") and further amended by Consent and Amendment No. 4, the "Amended
Agreement"; capitalized terms used herein without definition, having the
meanings provided in the Amended Agreement and the Credit Agreement), among the
Borrower, the lenders from time to time parties thereto (collectively, the
"Lenders"), and Bank of America, N.A., as administrative agent (in such
capacity, the "Administrative Agent") for the Lenders, Swing Line Lender and L/C
Issuer and certain other agents parties thereto, DO HEREBY CERTIFY on behalf of
the Borrower in such capacity and not individually, as follows:

          (i) the representations and warranties of the Borrower made in this
     Certificate and in the Loan Documents immediately after giving effect to
     the amendments and supplements contemplated by the Amended Agreement on the
     date hereof, are true and correct in all material respects on and as of the
     date hereof (i) except to the extent such representations and warranties
     specifically refer to an earlier date, in which case they are true and
     correct in all material respects as of such earlier date, (ii) except the
     representations and warranties contained in subsections (a) and (b) of
     Section 5.05 of the Amended Agreement shall be deemed to refer to the most
     recent financial statements furnished pursuant to subsections (a) and (b),
     respectively, of Section 6.01 of the Amended Agreement, and (iii) together
     with any additional items that will be disclosed on any updated Schedules
     required to be supplemented pursuant to Section 6.02(b) on the next
     scheduled delivery date, as to which the Borrower has notified the
     Administrative Agent in writing.

          (ii) after giving effect to Consent and Amendment No. 4, no event has
     occurred and is continuing that constitutes a Default.

                  [Remainder of this page intentionally blank]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Responsible Officer's
Certificate this __ day of September, 2006.

                                      POLYMEDICA CORPORATION

                                      By:
                                         ---------------------------------------
                                      Name:
                                           -------------------------------------
                                      Title:
                                            ------------------------------------<PAGE>

                                                                    Exhibit 10.1

                            FIRST AMENDMENT TO LEASE

     THIS FIRST AMENDMENT TO LEASE (this "Amendment") is dated for reference
purposes only as of August __, 2006, by and between CaRR NP Properties L.L.C., a
Delaware limited liability company ("Landlord"), and NAVISITE, INC., a Delaware
Corporation ("Tenant").

                                    RECITALS

     A. Landlord and Tenant are parties to that certain Lease dated as of April
30, 1999 (the "Existing Lease"), originally entered into by and between
CarrAmerica Realty Corporation, Landlord's predecessor-in-interest, and Tenant,
pursuant to which Landlord leases to Tenant certain premises in the building
located at 2720 Zanker Road, San Jose, California, containing approximately
66,350 rentable square feet (the "Premises"). The Existing Lease is scheduled to
expire on November 8, 2006.

     B. Notwithstanding the renewal options set forth in Section 31 of the
Existing Lease. Landlord and Tenant now desire to extend the Lease Term to
expire on November 30, 2016, and make certain other amendments to the Existing
Lease, all subject to, and on the basis of, the terms, covenants and conditions
hereinafter set forth. The Existing Lease, as amended by this Amendment, is
sometimes referred to herein as the "Lease."

     NOW, THEREFORE, in consideration of the foregoing and the agreements of
Landlord and Tenant herein contained and other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, Landlord and
Tenant hereby agree as follows:

     1. Use of Defined Terms; Recitals; Effective Date.

          1.1 Definitions; Recitals. All capitalized terms used and not defined
herein shall have the defined meanings ascribed to them in the Existing Lease.
The provisions of the Recitals above are fully incorporated herein by this
reference.

          1.2 Effective Date. Unless otherwise specifically provided herein, all
provisions of this Amendment shall be effective as of the date of execution set
forth under Landlord's signature below.

     2. Term. The Lease Term is hereby extended (the "Extension Term") for the
period commencing on November 9, 2006 (the "Extension Term Commencement Date"),
and continuing through November 30, 2016 (which, for all purposes under the
Lease, shall hereinafter be the "Termination Date"), unless earlier terminated
pursuant to the terms and conditions of the Lease. Tenant hereby agrees and
acknowledges that it has no options to extend the Term of the Lease beyond
November 30, 2016, and the provisions of Section 31 of the Existing Lease are
hereby deleted.

                                        1

<PAGE>

     3. Monthly Rent During Extension Term. As of the Extension Term
Commencement Date and thereafter during the Extension Term, Tenant shall pay
Base Rent in accordance with the following:

<TABLE>
<CAPTION>
                                           Annual        Monthly
Period                                   Base Rent      Base Rent
------                                 -------------   -----------
<S>                                    <C>             <C>
Extension Term Commencement
Date - November 30, 2008               $1,194,300.00   $ 99,525.00
December 1, 2008 - November 30, 2009   $1,592,400.00   $132,700.00
December 1, 2009 - November 30, 2010   $1,672,020.00   $139,335.00
December 1, 2010 - November 30, 2012   $1,791,450.00   $149,287.50
December 1, 2012 - November 30, 2014   $1,871,070.00   $155,922.50
December 1, 2014 - November 30, 2016   $1,950,690.00   $162,557.50
</TABLE>

     4. First Negotiation Rights. Sections 32 and 33 of the Existing Lease are
hereby deleted and shall be of no further force or effect.

     5. Tenant's Certification. Tenant hereby certifies to Landlord that, as of
the execution and delivery of this Amendment by Tenant to Landlord, there are no
existing defenses against the enforcement of any of the obligations of Tenant
under the Lease, and Landlord is not in default under the Lease by reason of its
failure to perform any obligations thereunder, and there is no circumstance,
event, condition or state of facts which, by the passage of time or the giving
of notice, or both, could entitle Tenant to any such defenses or constitute or
result in such a default.

     6. Real Estate Brokers. Tenant and Landlord represent and warrant that
neither party has utilized the services of any broker in connection with the
negotiation or execution of this Amendment, other than CB Richard Ellis.
Landlord shall be responsible for paying any and all commissions or fees owed
and due to CB Richard Ellis with regard to the subject matter of this Amendment.
Either party agrees to indemnify the other party and hold the other party
harmless from any and all costs (including attorneys' fees), expenses or
liability for commissions or other compensation claimed by any other broker or
agent claiming to have had dealings with a party in connection with this
Amendment.

     7. Miscellaneous.

          7.1 Ratification. Except as modified by this Amendment, all of the
terms, conditions and provisions of the Existing Lease shall remain in full
force and effect and are hereby ratified and confirmed.

          7.2 Conflict. To the extent the terms of the Existing Lease and this
Amendment are inconsistent, the terms of this Amendment shall control.

                                        2

<PAGE>

          7.3 No Offer. The submission of this Amendment to Tenant for
examination or execution does not create an option or constitute an offer to
Tenant to amend the Existing Lease on the terms and conditions contained herein,
and this Amendment shall not become effective as an amendment to the Existing
Lease unless and until it has been executed and delivered by both Landlord and
Tenant.

          7.4 Time of the Essence. Time is of the essence for each and every
provision of this Amendment.

          7.5 Entire Agreement. This Amendment contains the entire agreement of
Landlord and Tenant with respect to the subject matter hereof. It is understood
that there are no oral agreements between Landlord and Tenant affecting the
Existing Lease as hereby amended, and this Amendment supersedes and cancels any
and all previous negotiations, representations, agreements and understandings,
if any, between Landlord and Tenant and their respective agents with respect to
the subject matter thereof, and none shall be used to interpret or construe the
Lease. Tenant acknowledges that all prior communications from Landlord or its
agents are not and were not, and shall not be construed to be, representations
or warranties of Landlord or its agents as to the matters communicated, and have
not and will not be relied upon by Tenant.

         [The remainder of this page has been intentionally left blank]

     IN WITNESS WHEREOF, the parties have caused this Amendment to be executed
on the dates set forth below.

LANDLORD:                               TENANT:

CaRR NP Properties L.L.C.,              NAVISITE, INC.,
a Delaware limited liability company    a Delaware corporation

By: /s/ Marshall Findley                By: /s/ John J. Gavin, Jr.
    ---------------------------------       ------------------------------------
    Marshall Findley                    Name: John J. Gavin Jr.
    Managing Director and               Title: Chief Financial Officer
    Vice President

Date of Execution: 8/09/06              Date of Execution: August 4, 2006

                                        3

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