Document:

EX-10.8

 Exhibit 10.8 

CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED AND REPLACED WITH “[***]”. SUCH IDENTIFIED INFORMATION HAS BEEN
EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF DISCLOSED. 
  

 
  

CREDIT AGREEMENT AND GUARANTY 

DATED AS OF 

JUNE 5, 2020 

AMONG 
 C4
THERAPEUTICS, INC., 
 AS THE BORROWER, 

THE GUARANTORS FROM TIME TO TIME PARTY
HERETO, 
 AS GUARANTORS 

THE LENDERS FROM TIME TO TIME PARTY
HERETO, 
 AS LENDERS 

AND 

PERCEPTIVE CREDIT HOLDINGS III, LP, 

AND ITS SUCCESSORS AND ASSIGNS PARTY
HERETO, 
 AS ADMINISTRATIVE AGENT AND AS
A LENDER 
 $20,000,000 
  

 
  

 TABLE OF CONTENTS 

 

							
	 SECTION
	  	HEADING	  	 	PAGE	 
	 ARTICLE I
	  	 DEFINITIONS
	  	 	1	 
			
	 Section 1.01.
	  	Certain Defined Terms	  	 	1	 
	 Section 1.02.
	  	Accounting Terms and Principles	  	 	26	 
	 Section 1.03.
	  	Interpretation	  	 	27	 
	 Section 1.04.
	  	Divisions	  	 	27	 
			
	 ARTICLE 2
	  	 THE COMMITMENTS
	  	 	28	 
			
	 Section 2.01.
	  	Term Loans	  	 	28	 
	 Section 2.02.
	  	Proportionate Shares	  	 	29	 
	 Section 2.03.
	  	Fees	  	 	29	 
	 Section 2.04.
	  	Notes	  	 	29	 
	 Section 2.05.
	  	Use of Proceeds	  	 	29	 
			
	 ARTICLE 3
	  	 PAYMENTS OF PRINCIPAL AND
INTEREST
	  	 	29	 
			
	 Section 3.01.
	  	Repayment	  	 	29	 
	 Section 3.02.
	  	Interest	  	 	29	 
	 Section 3.03.
	  	Prepayments	  	 	31	 
			
	 ARTICLE 4
	  	 PAYMENTS, ETC.
	  	 	32	 
			
	 Section 4.01.
	  	Payments	  	 	32	 
	 Section 4.02.
	  	Computations	  	 	33	 
	 Section 4.03.
	  	Notices	  	 	33	 
	 Section 4.04.
	  	Set-Off	  	 	34	 
			
	 ARTICLE 5
	  	 YIELD PROTECTION, ETC.
	  	 	34	 
			
	 Section 5.01.
	  	Additional Costs	  	 	34	 
	 Section 5.02.
	  	Illegality	  	 	35	 
	 Section 5.03.
	  	Taxes	  	 	36	 
	 Section 5.04.
	  	Delay in Requests	  	 	40	 
			
	 ARTICLE 6
	  	 CONDITIONS PRECEDENT
	  	 	40	 
			
	 Section 6.01.
	  	Conditions to Tranche A Term Loan; Closing Date	  	 	40	 
	 Section 6.02.
	  	Conditions to Tranche B Term Loan; Tranche B Term Loan Borrowing Date	  	 	43	 
			
	 ARTICLE 7
	  	 REPRESENTATIONS AND WARRANTIES
	  	 	44	 
			
	 Section 7.01.
	  	Power and Authority	  	 	44	 
	 Section 7.02.
	  	Authorization; Enforceability	  	 	44	 
	 Section 7.03.
	  	Governmental and Other Approvals; No Conflicts	  	 	44	 

  
 -i- 

							
	 Section 7.04.
	  	Financial Statements; Material Adverse Change	  	 	45	 
	 Section 7.05.
	  	Properties	  	 	45	 
	 Section 7.06.
	  	No Actions or Proceedings	  	 	46	 
	 Section 7.07.
	  	Compliance with Laws and Agreements	  	 	47	 
	 Section 7.08.
	  	Taxes	  	 	47	 
	 Section 7.09.
	  	Full Disclosure	  	 	47	 
	 Section 7.10.
	  	Regulation	  	 	47	 
	 Section 7.11.
	  	Solvency	  	 	48	 
	 Section 7.12.
	  	Subsidiaries	  	 	48	 
	 Section 7.13.
	  	Indebtedness and Liens	  	 	48	 
	 Section 7.14.
	  	Material Agreements	  	 	48	 
	 Section 7.15.
	  	Restrictive Agreements	  	 	48	 
	 Section 7.16.
	  	Real Property	  	 	48	 
	 Section 7.17.
	  	Pension and Other Plans	  	 	48	 
	 Section 7.18.
	  	Collateral; Security Interest	  	 	49	 
	 Section 7.19.
	  	Regulatory Approvals	  	 	49	 
	 Section 7.20.
	  	Capitalization	  	 	51	 
	 Section 7.21.
	  	Insurance	  	 	52	 
	 Section 7.22.
	  	Certain Fees	  	 	52	 
	 Section 7.23.
	  	Sanctions Laws	  	 	52	 
	 Section 7.24.
	  	Anti-Corruption Laws	  	 	52	 
	 Section 7.25.
	  	Anti-Terrorism Laws	  	 	52	 
	 Section 7.26.
	  	Royalty and Other Payments	  	 	52	 
			
	 ARTICLE 8
	  	 AFFIRMATIVE COVENANTS AND FINANCIAL
COVENANTS
	  	 	52	 
			
	 Section 8.01.
	  	Financial Statements and Other Information	  	 	52	 
	 Section 8.02.
	  	Notices of Material Events	  	 	55	 
	 Section 8.03.
	  	Existence; Maintenance of Properties, Etc.	  	 	57	 
	 Section 8.04.
	  	Payment of Obligations	  	 	58	 
	 Section 8.05.
	  	Insurance	  	 	58	 
	 Section 8.06.
	  	Books and Records; Inspection Rights	  	 	58	 
	 Section 8.07.
	  	Compliance with Laws	  	 	59	 
	 Section 8.08.
	  	Licenses	  	 	59	 
	 Section 8.09.
	  	Action under Environmental Laws	  	 	59	 
	 Section 8.10.
	  	Use of Proceeds	  	 	59	 
	 Section 8.11.
	  	Certain Obligations Respecting Subsidiaries; Further Assurances; Intellectual Property	  	 	59	 
	 Section 8.12.
	  	Termination of Non-Permitted Liens	  	 	61	 
	 Section 8.13.
	  	Non-Consolidation	  	 	61	 
	 Section 8.14.
	  	Anti-Terrorism and Anti-Corruption Laws	  	 	61	 
	 Section 8.15.
	  	Minimum Liquidity	  	 	61	 
	 Section 8.16.
	  	Maintenance of Regulatory Approvals, Contracts, Intellectual Property, Etc.	  	 	61	 
	 Section 8.17.
	  	Cash Management	  	 	61	 
	 Section 8.18.
	  	Milestone	  	 	62	 

  
 -ii- 

							
	 Section 8.19.
	  	Certain Post-Closing Obligations	  	 	62	 
			
	 ARTICLE 9
	  	 NEGATIVE COVENANTS
	  	 	62	 
			
	 Section 9.01.
	  	Indebtedness	  	 	62	 
	 Section 9.02.
	  	Liens	  	 	63	 
	 Section 9.03.
	  	Fundamental Changes and Acquisitions	  	 	65	 
	 Section 9.04.
	  	Lines of Business	  	 	65	 
	 Section 9.05.
	  	Investments	  	 	65	 
	 Section 9.06.
	  	Restricted Payments	  	 	67	 
	 Section 9.07.
	  	Payments of Indebtedness	  	 	67	 
	 Section 9.08.
	  	Change in Fiscal Year	  	 	67	 
	 Section 9.09.
	  	Sales of Assets, Etc.	  	 	68	 
	 Section 9.10.
	  	Transactions with Affiliates	  	 	68	 
	 Section 9.11.
	  	Restrictive Agreements	  	 	69	 
	 Section 9.12.
	  	Organizational Documents, Material Agreements	  	 	69	 
	 Section 9.13.
	  	Operating Leases	  	 	69	 
	 Section 9.14.
	  	Sales and Leasebacks	  	 	70	 
	 Section 9.15.
	  	Hazardous Material	  	 	70	 
	 Section 9.16.
	  	Accounting Changes	  	 	70	 
	 Section 9.17.
	  	Compliance with ERISA	  	 	70	 
	 Section 9.18.
	  	Deposit Accounts	  	 	70	 
	 Section 9.19.
	  	Outbound Licenses	  	 	70	 
	 Section 9.20.
	  	Inbound Licenses	  	 	70	 
	 Section 9.21.
	  	Activities of Securities Subsidiary	  	 	71	 
			
	 ARTICLE 10
	  	 EVENTS OF DEFAULT
	  	 	71	 
			
	 Section 10.01.
	  	Events of Default	  	 	71	 
	 Section 10.02.
	  	Remedies	  	 	74	 
	 Section 10.03.
	  	Prepayment Fee and Redemption Price	  	 	74	 
			
	 ARTICLE 11
	  	 GUARANTEE
	  	 	75	 
			
	 Section 11.01.
	  	The Guarantee	  	 	75	 
	 Section 11.02.
	  	Obligations Unconditional	  	 	75	 
	 Section 11.03.
	  	Reinstatement	  	 	76	 
	 Section 11.04.
	  	Subrogation	  	 	76	 
	 Section 11.05.
	  	Remedies	  	 	76	 
	 Section 11.06.
	  	Instrument for the Payment of Money	  	 	76	 
	 Section 11.07.
	  	Continuing Guarantee	  	 	77	 
	 Section 11.08.
	  	Rights of Contribution	  	 	77	 
	 Section 11.09.
	  	General Limitation on Guarantee Obligations	  	 	77	 
			
	 ARTICLE 12
	  	 ADMINISTRATIVE AGENT
	  	 	78	 
			
	 Section 12.01.
	  	Appointment	  	 	78	 
	 Section 12.02.
	  	Rights as a Lender	  	 	78	 

  
 -iii- 

							
	 Section 12.03.
	  	Exculpatory Provisions	  	 	78	 
	 Section 12.04.
	  	Reliance by Administrative Agent	  	 	79	 
	 Section 12.05.
	  	Delegation of Duties	  	 	80	 
	 Section 12.06.
	  	Resignation of Agent	  	 	80	 
	 Section 12.07.
	  	Non-Reliance on Administrative Agent and Other Lenders	  	 	81	 
	 Section 12.08.
	  	Administrative Agent May File Proofs of Claim	  	 	81	 
	 Section 12.09.
	  	Collateral and Guaranty Matters; Appointment of Collateral Agent	  	 	81	 
			
	 ARTICLE 13
	  	 MISCELLANEOUS
	  	 	82	 
			
	 Section 13.01.
	  	No Waiver	  	 	82	 
	 Section 13.02.
	  	Notices	  	 	83	 
	 Section 13.03.
	  	Expenses, Indemnification, Etc.	  	 	83	 
	 Section 13.04.
	  	Amendments, Etc.	  	 	84	 
	 Section 13.05.
	  	Successors and Assigns	  	 	85	 
	 Section 13.06.
	  	Survival	  	 	88	 
	 Section 13.07.
	  	Captions	  	 	88	 
	 Section 13.08.
	  	Counterparts	  	 	88	 
	 Section 13.09.
	  	Governing Law	  	 	88	 
	 Section 13.10.
	  	Jurisdiction, Service of Process and Venue	  	 	89	 
	 Section 13.11.
	  	Waiver of Jury Trial	  	 	89	 
	 Section 13.12.
	  	Waiver of Immunity	  	 	89	 
	 Section 13.13.
	  	Entire Agreement	  	 	89	 
	 Section 13.14.
	  	Severability	  	 	90	 
	 Section 13.15.
	  	No Fiduciary Relationship	  	 	90	 
	 Section 13.16.
	  	USA Patriot Act	  	 	90	 
	 Section 13.17.
	  	Treatment of Certain Information; Confidentiality	  	 	90	 
	 Section 13.18.
	  	Releases of Guarantees and Liens	  	 	91	 
	 Section 13.19.
	  	Acknowledgement and Consent to Bail-In of EEA Financial Institutions	  	 	91	 

 SCHEDULES: 
  

					
	 SCHEDULE 1.01A
	 	—	  	 Commitments and Warrant Shares

	 SCHEDULE 1.01B
	 	—	  	 Permitted Investors

	 SCHEDULE 7.05(b)
	 	—	  	 Obligor Intellectual Property

	 SCHEDULE 7.13A
	 	—	  	 Existing Indebtedness

	 SCHEDULE 7.13B
	 	—	  	 Existing Liens

	 SCHEDULE 7.14
	 	—  	  	 Material Agreements

	 SCHEDULE 7.15
	 	—	  	 Restrictive Agreements

	 SCHEDULE 7.16
	 	—	  	 Real Property

	 SCHEDULE 7.17
	 	—	  	 Pension Matters

	 SCHEDULE 7.19(b)
	 	—	  	 Regulatory Approvals

  
 -iv- 

					
	 SCHEDULE 7.20
	 	—	  	 Capitalization

	 SCHEDULE 7.22
	 	—  	  	 Broker’s Fee

	 SCHEDULE 7.26
	 	—	  	 Royalty and Other Payments

	 SCHEDULE 8.19
	 	—	  	 Post-Closing Obligations

	 SCHEDULE 9.05
	 	—	  	 Existing Investments

	 SCHEDULE 9.10
	 	—	  	 Transactions with Affiliates

			
	 EXHIBITS:
	 		  	
			
	 EXHIBIT A
	 	—	  	 Form of Guarantee Assumption Agreement

	 EXHIBIT B
	 	—	  	 Form of Note

	 EXHIBIT C
	 	—	  	 Form of U.S. Tax Compliance Certificate

	 EXHIBIT D
	 	—	  	 Form of Compliance Certificate

	 EXHIBIT E
	 	—	  	 Form of Assignment Agreement

	 EXHIBIT F
	 	—	  	 Form of Sources and Uses Certificate

	 EXHIBIT G
	 	—	  	 Form of Security Agreement

	 EXHIBIT H
	 	—	  	 Form of Collateral Questionnaire

	 EXHIBIT I
	 	—	  	 Form of Borrowing Notice

  

  
 -v- 

 CREDIT AGREEMENT AND GUARANTY,
dated as of June 5, 2020 (this “Agreement”), among C4 THERAPEUTICS, INC., a Delaware corporation (the “Borrower”), certain Guarantors from time to time parties hereto,
PERCEPTIVE CREDIT HOLDINGS III, LP, a Delaware limited partnership (“Perceptive”), as a lender (together with its successors and assigns party hereto pursuant to Section 13.05, the
“Lenders” and each a “Lender”) and as administrative agent for the Lenders (in such capacity, together with its successors and assigns, the “Administrative Agent”). 

WITNESSETH: 

The Borrower has requested the Lenders to make term loans to the Borrower, and the Lenders are prepared to make such loans on and subject to
the terms and conditions hereof. Accordingly, the parties agree as follows: 
 ARTICLE I 

DEFINITIONS 

Section 1.01. Certain Defined Terms. As used herein, the
following terms have the following respective meanings: 
 “Accounting Change” has the meaning set forth
in Section 1.02. 
 “Accounting Change Notice” has the meaning set forth in Section 1.02. 

“Acquisition” means any transaction, or any series of related transactions, by which any Person directly or indirectly, by
means of a take-over bid, tender offer, amalgamation, merger, purchase of assets, or similar transaction having the same effect as any of the foregoing, (a) acquires all or substantially all of the assets
of any Person engaged in any business, (b) acquires all or substantially all of a business line or unit or division of any other Person, (c) acquires control of securities of a Person engaged in a business representing more than 50% of the
ordinary voting power (determined on a fully-diluted basis) for the election of directors or other governing body if the business affairs of such Person are managed by a board of directors or other governing body, or (d) acquires control of
more than 50% of the ownership interest (determined on a fully-diluted basis) in any Person engaged in any business that is not managed by a board of directors or other governing body. 

“Act” has the meaning set forth in Section 13.16. 

“Administrative Agent” has the meaning set forth in the introduction hereto. 

“Affiliate” means, with respect to a specified Person, another Person that directly, or indirectly through one or more
intermediaries, Controls or is Controlled by or is under common Control with the Person specified. 

 “Agreement” has the meaning set forth in the introduction hereto. 

“Anti-Corruption Laws” means all laws, rules and regulations of any
jurisdiction applicable to the Obligors and their Affiliates concerning or relating to bribery or corruption, including, without limitation, the Foreign Corrupt Practices Act of 1977, as amended. 

“Anti-Terrorism Laws” means any laws or regulations relating to terrorism or
money laundering, including, without limitation the Bank Secrecy Act (31 U.S.C. §§ 5311 et seq.), the Money Laundering Control Act of 1986 (18 U.S.C. §§ 1956 et seq.), the USA Patriot Act and
any similar law enacted in the United States after the date of this Agreement. 
 “Applicable Margin” means 9.50% per
annum, as such percentage may be increased by Section 3.02(d). 
 “Approved Fund” has the meaning set forth in
Section 13.05(c). 
 “Asset Sale” has the meaning set forth in Section 9.09. 

“Assignment Agreement” means an assignment and assumption entered into by a Lender and an assignee of such Lender in
substantially the form of Exhibit E. 
 “Bail-In Action” means the
exercise of any Write-Down and Conversion Powers by the applicable EEA Resolution Authority in respect of any liability of an EEA Financial Institution. 

“Bail-In Legislation” means, with respect to any EEA Member
Country implementing Article 55 of Directive 2014/59/EU of the European Parliament and of the Council of the European Union, the implementing law for such EEA Member Country from time to time which is described in the EU Bail-In Legislation Schedule. 
 “Bankruptcy Code” means Title 11 of the United
States Code entitled “Bankruptcy”. 
 “Benefit Plan” means any employee benefit plan as defined in
Section 3(3) of ERISA to which any Obligor or Subsidiary thereof incurs or otherwise has any obligation or liability, contingent or otherwise. 

“Borrower” has the meaning set forth in the introduction hereto. 

“Borrowing” means a borrowing consisting of the Tranche A Term Loan made by the Lenders on the Closing Date or the Tranche B
Term Loan made by the Lenders on the Tranche B Term Loan Borrowing Date. 
 “Borrowing Notice” means a notice substantially
in the form attached hereto as Exhibit I. 
 “Business Day” means a day (other than a Saturday or Sunday) on which
commercial banks are not authorized or not required to close in New York City and, when determined in connection with notices and determinations in respect of LIBOR or any Term Loan or any funding, Interest Period or any payments in respect of
the Term Loans, that is also a day on which dealings in dollar deposits are carried on in the London interbank market. 

  
 -2- 

 “Capital Lease Obligations” means, as to any Person, the obligations of
such Person to pay rent or other amounts under a lease of (or other agreement conveying the right to use) real and/or personal Property which obligations are required to be classified and accounted for as a capital lease on a balance sheet of such
Person under GAAP and, for purposes of this Agreement, the amount of such obligations shall be the capitalized amount thereof, determined substantially in accordance with GAAP; provided that any obligations that were not required to be
included on the balance sheet of such Person as capital lease obligations when incurred (whether now outstanding or at any time incurred or entered into) but are subsequently re-characterized as capital lease
obligations due to a change in accounting rules under GAAP after the Closing Date shall for all purposes hereunder not be treated as a Capital Lease Obligation. 

“Casualty Event” means any actual or constructive loss, condemnation, destruction, confiscation, requisition, seizure or
forfeiture of all or any material portion of the assets of the Borrower or any other Obligor, excluding only those assets, individually or in the aggregate, subject to any such event during any calendar year with a fair market value as of the date
thereof equal to or less than $500,000. 
 “Change of Control” means (a) prior to a Qualified Public Offering, any
“person” or “group” (within the meaning of Rule 13d-5 of the Exchange Act as in effect on the date hereof), other than the Permitted Investors, shall own, directly or indirectly,
beneficially or of record, shares representing more than 50% of the aggregate ordinary voting power represented by the issued and outstanding Equity Interests of Borrower, (b) after a Qualified Public Offering, any “person” or
“group” (within the meaning of Rule 13d-5 of the Exchange Act as in effect on the date hereof) shall own, directly or indirectly, beneficially or of record, shares representing more than 45% of the
aggregate ordinary voting power represented by the issued and outstanding Equity Interests of Borrower, (c) during any period of twelve (12) consecutive calendar months, the occupation of a majority of the seats (other than vacant seats)
on the board of directors of Borrower by Persons who were neither (i) nominated by the board of directors of Borrower, nor (ii) appointed by directors on the board of directors on the Closing Date, or (d) Borrower shall cease to
directly own, beneficially and of record, 100% of the issued and outstanding Equity Interests of each Subsidiary (determined on a fully diluted basis). 

“Claims” includes claims, litigation, demands, complaints, grievances, actions, applications, suits, causes of action,
orders, charges, indictments, prosecutions, information (brought by a public prosecutor without grand jury indictment) or other similar processes, assessments or reassessments. 

“Closing Date” means the date hereof. 

“Closing Fee” has the meaning set forth in Section 2.03. 

“Code” means the Internal Revenue Code of 1986, as amended from time to time. 

  
 -3- 

 “Collateral” means any Property in which a Lien is purported to be granted
under any of the Security Documents (or all such Property, as the context may require). 
 “Collateral Questionnaire” means
that certain Collateral Questionnaire and certification by a Responsible Officer of the Borrower substantially in the form of attached hereto as Exhibit H. 

“Commitment” means, with respect to each Lender, such Lender’s Tranche A Term Loan Commitment and Tranche B Term Loan
Commitment, and “Commitments” means all such commitments of all Lenders. The aggregate amount of the Commitments as of the Closing Date is $20,000,000. 

“Commodity Account” has the meaning set forth in the Security Agreement. 

“Competitor” means any Person that is a bona fide direct competitor of any Obligor in the same industry or a substantially
similar industry which offers a substantially similar product or service as any Obligor; provided that no Lender or Affiliate of a Lender shall be deemed to be a direct competitor of any Obligor as a result of such Lender or Affiliate of
such Lender being an investor in, owning or managing a business that may be a competitor of any Obligor. 
 “Compliance
Certificate” has the meaning set forth in Section 8.01(d). 
 “Connection Income Taxes” means Other
Connection Taxes that are imposed on or measured by net income (however denominated) or that are franchise Taxes or branch profits Taxes. 

“Contract Manufacturer” means each third party contract manufacturer or development partner involved in the development,
manufacture or distribution of a Product. 
 “Contracts” means any contract, license, instrument, lease, agreement,
obligation, promise, undertaking, understanding, arrangement, document, commitment, entitlement or engagement under which a Person has, or will have, any liability or contingent liability (in each case, whether written or oral, expressed or implied,
and whether in respect of monetary or payment obligations, performance obligations or otherwise), excluding the Loan Documents. 

“Control” means, with respect to any particular Person, the possession by one or more other Persons, directly or indirectly,
of the power to direct or cause the direction of the management or policies of such particular Person, whether through the ability to exercise voting power, by contract or otherwise. “Controlling” and “Controlled”
have meanings correlative thereto. 
 “Controlled Account” has the meaning set forth in Section 8.17(a). 

“Copyrights” has the meaning set forth in the Security Agreement. 

“Default” means any Event of Default and any event that, upon the giving of notice, the lapse of time or both, would
constitute an Event of Default. 

  
 -4- 

 “Default Rate” has the meaning set forth in Section 3.02(d). 

“Deposit Account” has the meaning set forth in the Security Agreement and relates to such accounts located and/or maintained
in the United States of America. 
 “Designated Person” means a person or entity: 

(a) listed in the annex to, or otherwise targeted by the provisions of, the Executive Order (as disclosed by World-Check or another reputable commercially available database); 
 (b) named as a
“Specially Designated National and Blocked Person” on the most current list published by OFAC at its official website or any replacement website or other replacement official publication of such list (as disclosed by World-Check or another reputable commercially available database); or 
 (c) with which the
Lenders are prohibited from dealing or otherwise engaging in any transaction by any Economic Sanctions Laws. 
 “Disqualified Equity
Interests” means, with respect to any Person, any Equity Interest of such Person that, by its terms (or by the terms of any security or other Equity Interest into which it is convertible or for which it is exchangeable upon exercise or
otherwise), or upon the happening of any event or condition (i) matures or is mandatorily redeemable (other than solely for Qualified Equity Interests), including pursuant to a sinking fund obligation or otherwise, (ii) is redeemable at
the option of the holder thereof (other than solely for Qualified Equity Interests), in whole or in part, (iii) provides for the scheduled payments of dividends or other distributions in cash or other securities that would constitute
Disqualified Equity Interests, or (iv) is or becomes convertible into or exchangeable for Indebtedness or any other Equity Interests that would constitute Disqualified Equity Interests, in each case, prior to the date that is one hundred and
eighty (180) days after the Stated Maturity Date; provided that, if such Equity Interests are issued pursuant to any plan for the benefit of directors, officers, employees or consultants of such Person or by any such plan to such
directors, officers, employees or consultants, such Equity Interests shall not constitute Disqualified Equity Interests solely because they may be required to be repurchased by such Person upon the death, disability, retirement or termination of
employment or service of such director, officer, employee or consultant. 
 “Domestic Subsidiary” means any Subsidiary that
is organized under the laws of the United States, any state thereof or the District of Columbia. 
 “EEA Financial Institution”
means (a) any credit institution or investment firm established in any EEA Member Country which is subject to the supervision of an EEA Resolution Authority, (b) any entity established in an EEA Member Country which is a parent of an
institution described in clause (a) of this definition, or (c) any financial institution established in an EEA Member Country which is a subsidiary of an institution described in clauses (a) or (b) of this definition and is
subject to consolidated supervision with its parent. 

  
 -5- 

 “EEA Member Country” means any of the member states of the European Union,
Iceland, Liechtenstein, and Norway. 
 “EEA Resolution Authority” means any public administrative authority or any person
entrusted with public administrative authority of any EEA Member Country (including any delegee) having responsibility for the resolution of any EEA Financial Institution. 

“Economic Sanctions Laws” means: 

(a) the Executive Order, the International Emergency Economic Powers Act (50 U.S.C. §§ 1701
et seq.), the Trading with the Enemy Act (50 U.S.C. App. §§ 1 et seq.), any other law or regulation promulgated thereunder from time to time and administered by OFAC and any
similar law enacted in the United States after the date of this Agreement; and 
 (b) any other similar applicable law now or
hereafter enacted in any other applicable jurisdiction. 
 “Environmental Law” means any federal, state, provincial or
local governmental law, rule, regulation, order, writ, judgment, injunction or decree relating to pollution or protection of the environment or the treatment, storage, disposal, release, threatened release or handling of hazardous materials, and all
local laws and regulations related to environmental matters and any specific agreements entered into with any competent authorities which include commitments related to environmental matters. 

“Equity Interest” means, with respect to any Person, any and all shares, interests, participations or other equivalents,
including membership interests (however designated, whether voting or nonvoting), of equity of such Person, including, if such Person is a partnership, partnership interests (whether general or limited) and any other interest or participation that
confers on a Person the right to receive a share of the profits and losses of, or distributions of property of, such partnership, but excluding debt securities convertible or exchangeable into such equity. 

“ERISA” means the United States Employee Retirement Income Security Act of 1974, as amended. 

“ERISA Affiliate” means, collectively, any Obligor, Subsidiary thereof, and any Person under common control, or treated as a
single employer, with any Obligor or Subsidiary thereof, within the meaning of Section 414(b), (c), (m) or (o) of the Code. 

“ERISA Event” means (i) a reportable event as defined in Section 4043 of ERISA with respect to a Title IV
Plan, excluding, however, such events as to which the PBGC by regulation has waived the requirement of Section 4043(a) of ERISA that it be notified within thirty (30) days of the occurrence of such event; (ii) the applicability of the
requirements of Section 4043(b) of ERISA with respect to a contributing sponsor, as defined in Section 4001(a)(13) of ERISA, to any Title IV Plan where an event described in paragraph (9), (10), (11), (12) or (13) of
Section 4043(c) of ERISA is reasonably expected to occur with respect to such plan within the following thirty 

  
 -6- 

 
(30) days; (iii) a withdrawal by any Obligor or any ERISA Affiliate thereof from a Title IV Plan or the termination of any Title IV Plan resulting in liability under
Sections 4063 or 4064 of ERISA; (iv) the withdrawal of any Obligor or any ERISA Affiliate thereof in a complete or partial withdrawal (within the meaning of Section 4203 and 4205 of ERISA) from any Multiemployer Plan if there is any
potential liability therefore, or the receipt by any Obligor or any ERISA Affiliate thereof of notice from any Multiemployer Plan that it is in reorganization or insolvency pursuant to Section 4241 or 4245 of ERISA; (v) the filing of a
notice of intent to terminate, the treatment of a plan amendment as a termination under Section 4041 or 4041A of ERISA, or the commencement of proceedings by the PBGC to terminate a Title IV Plan or Multiemployer Plan; (vi) the
imposition of liability on any Obligor or any ERISA Affiliate thereof pursuant to Sections 4062(e) or 4069 of ERISA or by reason of the application of Section 4212(c) of ERISA; (vii) the failure by any Obligor or any ERISA Affiliate
thereof to make any required contribution to a Plan, or the failure to meet the minimum funding standard of Section 412 of the Code with respect to any Title IV Plan (whether or not waived in accordance with Section 412(c) of the
Code) or the failure to make by its due date a required installment under Section 430 of the Code with respect to any Title IV Plan or the failure to make any required contribution to a Multiemployer Plan; (viii) the determination
that any Title IV Plan is considered an at-risk plan or a plan in endangered to critical status within the meaning of Sections 430, 431 and 432 of the Code or Sections 303, 304 and 305 of ERISA;
(ix) an event or condition which might reasonably be expected to constitute grounds under Section 4042 of ERISA for the termination of, or the appointment of a trustee to administer, any Title IV Plan or Multiemployer Plan;
(x) the imposition of any liability under Title I or Title IV of ERISA, other than PBGC premiums due but not delinquent under Section 4007 of ERISA, upon any Obligor or any ERISA Affiliate thereof; (xi) an application for a
funding waiver under Section 303 of ERISA or an extension of any amortization period pursuant to Section 412 of the Code with respect to any Title IV Plan; (xii) the occurrence of a
non-exempt prohibited transaction under Sections 406 or 407 of ERISA for which any Obligor or any Subsidiary thereof may be directly or indirectly liable; (xiii) a violation of the applicable
requirements of Section 404 or 405 of ERISA or the exclusive benefit rule under Section 401(a) of the Code by any fiduciary or disqualified person for which any Obligor or any ERISA Affiliate thereof may be directly or indirectly liable;
(xiv) the occurrence of an act or omission which could give rise to the imposition on any Obligor or any ERISA Affiliate thereof of fines, penalties, Taxes or related charges under Chapter 43 of the Code or under Sections 409, 502(c),
(i) or (1) or 4071 of ERISA; (xv) the assertion of a material claim (other than routine claims for benefits) against any Plan or the assets thereof, or against any Obligor or any Subsidiary thereof in connection with any such plan;
(xvi) receipt from the IRS of notice of the failure of any Qualified Plan to qualify under Section 401(a) of the Code, or the failure of any trust forming part of any Qualified Plan to fail to qualify for exemption from taxation under
Section 501(a) of the Code; (xvii) the imposition of any lien (or the fulfillment of the conditions for the imposition of any lien) on any of the rights, properties or assets of any Obligor or any ERISA Affiliate thereof, in either case
pursuant to Title I or IV, including Section 302(f) or 303(k) of ERISA or to Section 401(a)(29) or 430(k) of the Code; or (xviii) the establishment or amendment by any Obligor or any Subsidiary thereof of any “welfare
plan,” as such term is defined in Section 3(1) of ERISA, that provides post-employment welfare benefits in a manner that would increase the liability of any Obligor, other than those benefits
required under the Consolidated Omnibus Budget Reconciliation Act. 

  
 -7- 

 “ERISA Funding Rules” means the rules regarding minimum required
contributions (including any installment payment thereof) to Title IV Plans, as set forth in Sections 412, 430, 431, 432 and 436 of the Code and Sections 302, 303, 304 and 305 of ERISA. 

“EU Bail-In Legislation Schedule” means the EU
Bail-In Legislation Schedule published by the Loan Market Association (or any successor Person), as in effect from time to time. 

“Event of Default” has the meaning set forth in Section 10.01. 

“Excess Funding Guarantor” has the meaning set forth in Section 11.08. 

“Excess Payment” has the meaning set forth in Section 11.08. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 “Excluded Accounts” means deposit accounts exclusively used for payroll, payroll taxes and other employee wage and
benefit payments to or for the benefit of the employees of the Borrower and its Subsidiaries and deposit accounts holding in trust funds not owned by Borrower or its Subsidiaries. 

“Excluded Taxes” means any of the following Taxes imposed on or with respect to a Recipient or required to be withheld or
deducted from a payment to a Recipient: (a) Taxes imposed on or measured by net income (however denominated), franchise Taxes and branch profits Taxes in each case (i) imposed as a result of such Recipient being organized under the laws
of, or having its principal office or, in the case of a Lender, its applicable lending office located in, the jurisdiction imposing such Tax or (ii) that are Other Connection Taxes, (b) any U.S. federal withholding Taxes that are
imposed on amounts payable to Lender to the extent that the obligation to withhold amounts existed on the date that (i) Lender became a “Lender” under this Agreement or (ii) Lender changes its lending office, except in each case
to the extent Lender is a direct or indirect assignee of any other Lender that was entitled, at the time the assignment of such other Lender became effective, to receive additional amounts under Section 5.03 or Lender was entitled to receive
additional amounts under Section 5.03 immediately before it changed its lending office, (c) any Taxes imposed in connection with FATCA, and (d) Taxes attributable to such Recipient’s failure to comply with Section 5.03(e).

 “Executive Order” means the US Executive Order No. 13224 on Blocking Property and Prohibiting Transactions with
Persons who commit, Threaten to Commit, or Support Terrorism. 
 “Expense Deposit” means a cash deposit in the amount of
$50,000 made by the Borrower to an Affiliate of Perceptive Advisors LLC pursuant to the Proposal Letter for the prepayment of the Lenders’ reasonable and documented
out-of-pocket costs and expenses (payable pursuant to Section 13.03(a) and/or the Proposal Letter) incurred prior to the Closing Date. 

  
 -8- 

 “FATCA” means Sections 1471 through 1474 of the Code, as of the date of
this Agreement (or any amended or successor version that is substantively comparable and not materially more onerous to comply with), any current or future regulations or official interpretations thereof, any agreements entered into pursuant to
Section 1471(b)(1) of the Code and any fiscal or regulatory legislation, rules or practices adopted pursuant to any intergovernmental agreement, treaty or convention among Governmental Authorities entered into in connection with the
implementation of the foregoing. 
 “FD&C Act” means the U.S. Food, Drug and Cosmetic Act of 1938 (or any successor
thereto), as amended from time to time, and the rules, regulations, guidelines, guidance documents and compliance policy guides issued or promulgated thereunder. 

“FDA” means the U.S. Food and Drug Administration and any successor entity. 

“FDA Laws” means (i) the FD&C Act and its implementing regulations; (ii) the Federal Controlled Substances Act
and its implementing regulations; (iii) the Controlled Substances Import and Export Act and its implementing regulations; (iv) all terms and conditions of any pending or approved Product Authorization; (v) any state board of pharmacy
Laws; (vi) any state Laws pertaining the possession, distribution, or use of controlled substances; (vii) any other applicable Laws of any jurisdiction governing the research, development and approval, testing, manufacturing, processing,
handling, packaging, labeling, storage, advertising, promotion, marketing, sale and distribution of drugs, medical devices or “combination products” (as defined at 21 CFR 3.2); and (viii) all other applicable Laws administered or
issued by the FDA. 
 “Federal Health Care Program” has the meaning specified in Section 1128B(f) of the Social
Security Act and includes the programs commonly known as Medicare, Medicaid, TRICARE and CHAMPVA. 
 “Financial Forecast”
has the meaning set forth in Section 8.01(i) 
 “Foreign Lender” means a Lender that is not a U.S. Person. 

“Foreign Subsidiary” means any Subsidiary that is not a Domestic Subsidiary. 

“GAAP” means generally accepted accounting principles in the United States of America, as in effect from time to time, set
forth in the opinions and pronouncements of the Accounting Principles Board and the American Institute of Certified Public Accountants, in the statements and pronouncements of the Financial Accounting Standards Board and in such other statements by
such other entity as may be in general use by significant segments of the accounting profession that are applicable to the circumstances as of the date of determination. Subject to Section 1.02, all references to “GAAP” shall be to
GAAP applied consistently with the principles used in the preparation of the financial statements described in Section 7.04(a). 

“Governmental Approval” means any consent, authorization, approval, order, license, franchise, permit, certification,
accreditation, registration, clearance, exemption, filing or notice that is issued or granted by or from (or pursuant to any act of) any Governmental Authority, including any application or submission related to any of the foregoing. 

  
 -9- 

 “Governmental Authority” means any nation, government, branch of power
(whether executive, legislative or judicial), state, municipality or other political subdivision thereof and any entity exercising executive, legislative, judicial, monetary, regulatory or administrative functions of or pertaining to government,
including without limitation Regulatory Authorities, governmental departments, agencies, commissions, bureaus, officials, ministers, courts, bodies, boards, tribunals and dispute settlement panels, and other
law-, rule- or regulation-making organizations or entities of any State, territory, county, city or other political subdivision
of the United States or any foreign country. 
 “Guarantee” of or by any Person (the “guarantor”) means
any obligation, contingent or otherwise, of the guarantor guaranteeing or having the economic effect of guaranteeing any Indebtedness or other obligation of any other Person (the “primary obligor”) in any manner, whether directly or
indirectly, and including any obligation of the guarantor, direct or indirect, (a) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or other obligation or to purchase (or to advance or supply
funds for the purchase of) any security for the payment thereof, (b) to purchase or lease property, securities or services for the purpose of assuring the owner of such Indebtedness or other obligation of the payment thereof, (c) to
maintain working capital, equity capital or any other financial statement condition or liquidity of the primary obligor so as to enable the primary obligor to pay such Indebtedness or other obligation or (d) as an account party in respect of
any letter of credit or letter of guaranty issued to support such Indebtedness or obligation; provided, that the term Guarantee shall not include endorsements for collection or deposit in the Ordinary Course of Business. 

“Guarantee Assumption Agreement” means a Guarantee Assumption Agreement substantially in the form of Exhibit A by an
entity that, pursuant to Section 8.11(a), is required to become a “Guarantor”. 
 “Guaranteed Obligations”
has the meaning set forth in Section 11.01. 
 “Guarantor” means, (i) initially, each of the Subsidiaries of the
Borrower listed as a Guarantor on the signature pages hereto and (ii) any other Subsidiary of the Borrower joined as a Guarantor from time to time pursuant to Section 8.11. For the avoidance of doubt, there are no Guarantors as of the
Closing Date. 
 “Hazardous Material” means any substance, element, chemical, compound, product, solid, gas, liquid, waste,
by-product, pollutant, contaminant or material which is hazardous or toxic, and includes, without limitation, (a) asbestos, polychlorinated biphenyls and petroleum (including crude oil or any fraction
thereof) and (b) any material classified or regulated as “hazardous” or “toxic” or words of like import pursuant to an Environmental Law. 

“Healthcare Laws” means, collectively, all Laws applicable to the business of the Borrower or any other Obligor regulating
the manufacturing, sale, distribution, labeling, marketing, promotion, export, or the provision of and payment for, health care products (including the Products), items and services, including but not limited to (i) all applicable Laws relating
to the privacy or security of consumer information, including but not limited to the Health Insurance Portability and Accountability Act of 1996 (Pub. L. No. 104-191) (“HIPAA”) and any
similar state 

  
 -10- 

 
laws; (ii) all applicable federal and state fraud and abuse Laws, including but not limited to the federal Anti-Kickback Statute (42 U.S.C. §1320a-7b(b) and any similar state laws), the federal Physician Self-Referral Prohibition (commonly referred to as the “Stark Law”) (42 U.S.C.
§ 1395nn and any similar state laws), the Civil Monetary Penalties Act (42 U.S.C. §1320a-7a), and the civil False Claims Act (31 U.S.C. §3729 et seq. and any
similar state laws); (iii) all applicable FDA Laws; (iv) the licensure and registration of drug or device manufacturers; and (v) all applicable rules and regulations promulgated under or pursuant to any of the foregoing. 

“Hedging Agreement” means any interest rate exchange agreement, foreign currency exchange agreement, commodity price
protection agreement or other interest or currency exchange rate or commodity price hedging arrangement. 
 “IND” means
(x) an Investigational New Drug Application (as defined in the FD&C Act) that is required to be submitted to the FDA before beginning a clinical trial in human subjects, and (y) any similar application relating to any investigational
new drug or clinical trial required by any country, jurisdiction or Governmental Authority other than the FDA. 

“Indebtedness” of any Person means, without duplication, (i) all obligations of such Person for borrowed money,
(ii) all obligations of such Person evidenced by bonds, debentures, notes, loan agreements or similar instruments, (iii) all obligations of such Person upon which interest charges are customarily paid, (iv) all obligations of such
Person under conditional sale or other title retention agreements relating to Property acquired by such Person, (v) all obligations of such Person in respect of the deferred purchase price of Property or services (excluding accounts payable
incurred in the Ordinary Course of Business not overdue by more than one hundred twenty (120) days), (vi) all Indebtedness of others secured by (or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be
secured by) any Lien on Property owned or acquired by such Person, whether or not the Indebtedness secured thereby has been assumed, (vii) all Guarantees by such Person of Indebtedness of others, (viii) all Capital Lease Obligations of
such Person, (ix) all obligations, contingent or otherwise, of such Person as an account party in respect of letters of credit and letters of guaranty, (x) obligations under any Hedging Agreement, currency swaps, forwards, futures or
derivatives transactions, (xi) all obligations, contingent or otherwise, of such Person in respect of bankers’ acceptances, and (xii) any Disqualified Equity Interests of such Person, and (xiii) all other obligations required to
be classified as indebtedness of such Person under GAAP. The Indebtedness of any Person shall include the Indebtedness of any other entity (including any partnership in which such Person is a general partner) to the extent such Person is liable
therefor as a result of such Person’s ownership interest in or other relationship with such entity, except to the extent the terms of such Indebtedness provide that such Person is not liable therefor. 

“Indemnified Party” has the meaning set forth in Section 13.03(b). 

“Indemnified Taxes” means (a) Taxes, other than Excluded Taxes, imposed on or with respect to any payment made by or on
account of any Obligation and (b) to the extent not otherwise described in clause (a), Other Taxes. 

“Information” has the meaning set forth in Section 13.17. 

  
 -11- 

 “Insolvency Proceeding” means (a) any case, action or proceeding
before any court or other Governmental Authority relating to bankruptcy, reorganization, insolvency, liquidation, receivership, dissolution, winding-up or relief of debtors, or (b) any general assignment
for the benefit of creditors, composition, marshaling of assets for creditors, or other, similar arrangement in respect of any Person’s creditors generally or any substantial portion of such Person’s creditors, in each case undertaken
under U.S. Federal, state or foreign law, including the Bankruptcy Code. 
 “Intellectual Property” means, with respect to
any Person, all of such Person’s rights, title and interest in and to all Patents, Trademarks, Copyrights, industrial designs, Technical Information, whether registered or not and whether existing under U.S. or
non-U.S. Law or jurisdiction, including, without limitation, all: 
 (a)
applications, registrations, amendments and extensions relating to such Intellectual Property; 
 (b) rights and privileges
arising under any applicable Laws with respect to any Intellectual Property; 
 (c) rights to sue for or collect any damages
for any past, present or future infringements of any Intellectual Property; and 
 (d) rights of the same or similar effect
or nature as described above in any jurisdiction corresponding to any Intellectual Property throughout the world. 
 “Interest
Period” means, (a) initially, the period beginning on (and including) the Closing Date and ending on (and including) the last day of the calendar month in which the Closing Date occurs, and (b) thereafter, the period beginning on
(and including) the first day of each succeeding calendar month and ending on the earlier of (and including) (x) the last day of such calendar month and (y) the Maturity Date. 

“Invention” means any novel, inventive or useful art, apparatus, method, process, machine (including any article or device),
manufacture or composition of matter, or any novel, inventive and useful improvement in any art, method, process, machine (including any article or device), manufacture or composition of matter. 

“Investment” means, for any Person: (a) the acquisition (whether for cash, Property, services or securities or
otherwise) of Equity Interests, bonds, notes, debentures, partnership or other ownership interests or other securities of any other Person or any agreement to make any such acquisition (including any “short sale” or any sale of any
securities at a time when such securities are not owned by the Person entering into such sale); (b) the making of any deposit with, or advance, loan, assumption of debt or other extension of credit to, any other Person (including the purchase
of Property from another Person subject to an understanding or agreement, contingent or otherwise, to resell such Property to such Person), but excluding any such advance, loan or extension of credit in the nature of an ordinary course trade
receivable having a term not exceeding one hundred twenty (120) days arising in connection with the sale of services, inventory or supplies by such Person in the Ordinary Course of Business; (c) the entering into of any Guarantee of, or

  
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other contingent obligation with respect to, Indebtedness or other liability of any other Person and (without duplication) any amount committed to be advanced, lent or extended to such Person;
(d) entering into any joint venture or (e) the entering into of any Hedging Agreement. The amount of an Investment will be determined at the time the Investment is made without giving effect to any subsequent changes in value. 

“IRS” means the U.S. Internal Revenue Service or any successor agency, and to the extent relevant, the U.S. Department of the
Treasury. 
 “Laws” means, collectively, all international, foreign, federal, state, provincial, territorial, municipal and
local statutes, treaties, rules, regulations, ordinances, codes and administrative or judicial precedents or authorities, including the interpretation or administration thereof by any Governmental Authority charged with the enforcement,
interpretation or administration thereof, and all applicable administrative orders, directed duties, requests, licenses, authorizations and permits of, and agreements with, any Governmental Authority, in each case whether or not having the force of
law. 
 “Lenders” has the meaning set forth in the introduction hereto. 

“LIBOR” means, for any Interest Period, the rate per annum (rounded upwards if necessary, to the next 1/100%) equal to the
London interbank offered for one-month deposits in Dollars appearing on the appropriate Bloomberg screen or the Dow Jones Markets Telerate Page 3750 as of 11:00 a.m. (London time) two (2)
Business Days prior to the commencement of any Interest Period; provided, that in the event that such rate does not appear on the appropriate Bloomberg screen or the Dow Jones Markets Telerate Page 3750 (or otherwise on the Dow Jones Markets
screen) at such time, “LIBOR” shall be determined by reference to such other comparable publicly available service for displaying the offered rate for deposit in Dollars in the London interbank market as may be selected by the Majority
Lenders; provided, further, that in no event shall LIBOR be less than 1.75%. 
 “Lien” means any mortgage,
lien, pledge, charge or other security interest, or any lease, title retention agreement, mortgage, restriction, easement, right-of-way, option or adverse claim (of
ownership or possession) or other encumbrance of any kind or character whatsoever or any preferential arrangement that has the practical effect of creating a security interest. 

“Loan Documents” means, collectively, this Agreement, the Notes, the Security Documents, any Guarantee Assumption Agreement,
each Warrant and any subordination agreement, intercreditor agreement or other present or future document, instrument, agreement or certificate delivered to any Lender in connection with this Agreement or any of the other Loan Documents, in each
case, as amended, restated, supplemented or otherwise modified. 
 “Loan Exposure” means, with respect to any Lender, as of
any date of determination, the outstanding principal amount of such Lender’s portion of the Term Loans; provided, at any time prior to the making of the Term Loans, the Loan Exposure of any Lender shall be equal to such Lender’s
Commitment. 

  
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 “Loss” means judgments, debts, liabilities, expenses, costs, damages or
losses, contingent or otherwise, whether liquidated or unliquidated, matured or unmatured, disputed or undisputed, contractual, legal or equitable, including loss of value, professional fees, including fees and disbursements of legal counsel on a
full indemnity basis, and all costs incurred in investigating or pursuing any Claim or any proceeding relating to any Claim. 

“M&A Event” means, (a) a merger, consolidation or exchange in which (i) the Borrower is a
constituent party or (ii) a Subsidiary of the Borrower is a constituent party and the Borrower issues shares of its Equity Interests pursuant to such merger, consolidation or exchange, except for any such merger, consolidation
or exchange involving the Borrower or a Subsidiary in which the shares of Equity Interests of the Borrower outstanding immediately prior to such merger, consolidation or exchange continue to represent, or are converted into or exchanged for shares
of Equity Interests that represent, immediately following such merger or consolidation, at least a majority, by voting power, of the Equity Interests of (x) the surviving or resulting company; or (y) if the surviving or resulting company
is a wholly owned Subsidiary of another entity immediately following such merger, consolidation or exchange, the parent entity of such surviving or resulting company; or (b) the sale, lease, transfer, exclusive license or other disposition, in
a single transaction or series of related transactions, by the Borrower of all or substantially all the assets of the Borrower and its Subsidiaries, taken as a whole, or the sale or disposition (whether by merger, consolidation or otherwise) of
one or more Subsidiaries of the Borrower if substantially all of the assets of the Borrower and its Subsidiaries, taken as a whole, are held by such Subsidiary or Subsidiaries, except where such sale, lease, transfer, exclusive license or other
disposition is to a wholly owned Subsidiary of the Borrower.
 “Majority Lenders” means, at any time, one or more Lenders
having or holding Loan Exposure and representing more than 50% of the aggregate Loan Exposure of all Lenders. 
 “Margin
Stock” means “margin stock” within the meaning of Regulations U and X. 
 “Material Adverse Change” and
“Material Adverse Effect” mean a material adverse change in or effect on (a) the business, financial condition, operations, or Property of the Obligors taken as a whole, (b) the ability of any Obligor to perform its
obligations under any Loan Document, (c) the value of the Property comprising Collateral (taken as a whole), or (d) the legality, validity, binding effect or enforceability of the Loan Documents or the rights and remedies of any Lender
under any of the Loan Documents. 
 “Material Agreement” means (a) any Contract which is listed in Schedule 7.14,
(b) any other Contract to which the Borrower or any of its Subsidiaries is a party or a beneficiary from time to time, or to which any assets or properties of the Borrower or any of its Subsidiaries is bound, the absence or termination of which
would reasonably be expected to result in a Material Adverse Effect, and (c) any other Contract to which the Borrower or any of its Subsidiaries is a party or a guarantor (or equivalent) whether existing as of the date hereof or in the future
that during any period of twelve (12) consecutive months is reasonably expected to (1) result in payments or receipts (including royalty, licensing or similar payments) made to the Borrower or any of its Subsidiaries in an aggregate amount
in excess of $1,000,000 or (2) require payments or expenditures (including royalty, licensing or similar payments) made by the Borrower or any of its Subsidiaries in an aggregate amount in excess of $1,000,000. 

  
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 “Material Indebtedness” means, at any time, any Indebtedness of any
Obligor, the outstanding principal amount of which, individually or in the aggregate, exceeds $750,000. 
 “Material Intellectual
Property” means all Obligor Intellectual Property, whether currently owned or licensed, or acquired, developed or otherwise licensed or obtained after the date hereof (a) necessary for the operation of the business of the Borrower and
its Subsidiaries as currently conducted or as currently contemplated to be conducted, including all current and contemplated Product Development and Commercialization Activities relating to the Products, (b) the loss of which would reasonably
be expected to have or result in a Material Adverse Effect or (c) that has a fair market value in excess of $1,000,000. 

“Maturity Date” means the earlier to occur of (i) the Stated Maturity Date, and (ii) the date on which the Term
Loans are accelerated pursuant to Section 10.02. 
 “Minimum Liquidity” has the meaning set forth in
Section 8.15. 
 “Multiple on Invested Capital” means, as of any date of determination a positive amount equal to
[(TAP × .4) – (TR)] × (TLR ÷ TAP), where: 
 TAP = the total
aggregate principal amount of the Term Loans borrowed as of such date of determination. 
 TR = the “Total
Return”, which is the aggregate amount of interest payments (excluding any interest payments payable at the Default Rate pursuant to Section 3.02(c)) and fees received by the Lenders on or before such date of determination (including the
Closing Fee and any Prepayment Fees, but excluding any return on or in respect of the Warrants). 
 TLR = the total
aggregate principal amount of the Term Loans repaid as of such date of determination. 
 “Multiemployer Plan” means any
multiemployer plan, as defined in Section 400l(a)(3) of ERISA, to which any ERISA Affiliate incurs or otherwise has any obligation or liability, contingent or otherwise. 

“NDA” means (i) (x) a New Drug Application or Abbreviated New Drug Application (each as defined in the FD&C Act)
that must be submitted to the FDA and (y) any similar application required by any country, jurisdiction or Governmental Authority other than the FDA that must be approved before a drug can be marketed, and (ii) all supplements and
amendments that may be submitted to permit any changes to an approved NDA. 

  
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 “Net Cash Proceeds” means, (a) with respect to any Casualty Event
experienced or suffered by an Obligor, the amount of cash proceeds actually received from time to time by or on behalf of such Obligor after deducting therefrom only (i) actual costs and expenses related thereto incurred by such Obligor in
connection therewith and (ii) Taxes paid or payable in connection therewith and (b) with respect to a Qualified Public Offering, the excess, if any, of (i) the sum of the cash received in connection with such offering over
(ii) underwriting discounts, commissions, costs and other reasonable and customary expenses (including reasonable attorney’s, accountant’s and other similar professional advisor’s fees), incurred by an Obligor in connection with
such offering. 
 “Note” means a promissory note executed and delivered by the Borrower to any Lender in accordance with
Section 2.04. 
 “Obligations” means, with respect to any Obligor, all amounts, obligations (including, without
limitation, all Warrant Obligations), liabilities, covenants and duties of every type and description owing by such Obligor to any Lender or any other Indemnified Party hereunder, arising out of, under, or in connection with, any Loan Document,
whether direct or indirect (regardless of whether acquired by assignment), absolute or contingent, due or to become due, whether liquidated or not, now existing or hereafter arising and however acquired, and whether or not evidenced by any
instrument for the payment of money, including, without duplication, (a) the principal amount of the Term Loans, (b) all interest, whether or not accruing after the filing of any petition in bankruptcy or after the commencement of any
insolvency, reorganization or similar proceeding, and whether or not a claim for post-filing or post-petition interest is allowed in any such proceeding, (c) the
Prepayment Fee, and (d) all other fees, expenses (including fees, charges and disbursement of counsel), interest, commissions, charges, costs, disbursements, indemnities and reimbursement of amounts paid and other sums chargeable to such
Obligor under any Loan Document. 
 “Obligor Intellectual Property” means, at any time of determination, Intellectual
Property owned by, licensed to or otherwise held by any Obligor at such time including, without limitation, the Intellectual Property listed on Schedule 7.05(b). 

“Obligors” means, collectively, the Borrower, each Guarantor and each of their respective successors and permitted assigns.

 “OFAC” means the Office of Foreign Assets Control of the U.S. Department of the Treasury (or any successor
thereto). 
 “Ordinary Course of Business” means, with respect to the Obligors, the ordinary course of business generally
consistent with past custom and practice (including with respect to nature, scope, magnitude, quantity and frequency). 

“Organizational Documents” means (a) with respect to any corporation, its certificate or articles of incorporation or
organization, as amended, and its by-laws, as amended, (b) with respect to any limited partnership, its certificate of limited partnership, as amended, and its partnership agreement, as amended,
(c) with respect to any general partnership, its partnership agreement, as amended, and (d) with respect to any limited liability company, its articles of organization, as amended, and its operating agreement, as amended. In the event any
term or condition of this Agreement or any other Loan Document requires any Organizational Document to be certified by a secretary of state or similar government official, the reference to any such “Organizational Document” shall only be
to a document of a type customarily certified by such government official. 

  
 -16- 

 “Other Connection Taxes” means, with respect to any Recipient, Taxes
imposed as a result of a present or former connection between such Recipient and the jurisdiction imposing such Tax (other than connections arising solely from such Recipient having executed, delivered, become a party to, performed its obligations
under, received payments under, received or perfected a security interest under, engaged in any other transaction pursuant to or enforced any Loan Document, or sold or assigned an interest in any Term Loan or Loan Document). 

“Other Taxes” means all present or future stamp, court or documentary, intangible, recording, filing or similar Taxes that
arise from any payment made under, from the execution, delivery, performance, enforcement or registration of, from the receipt or perfection of a security interest under, or otherwise with respect to, any Loan Document, except any such Taxes that
are Other Connection Taxes imposed with respect to an assignment (other than an assignment made pursuant to Section 5.03(h)). 

“Participant” has the meaning set forth in Section 13.05(e). 

“Participant Register” has the meaning set forth in Section 13.05(f). 

“Patents” has the meaning set forth in the Security Agreement. 

“Payment Date” means the last day of each Interest Period; provided that if such last day of such Interest Period is
not a Business Day, then the Payment Date for such Interest Period will be the next succeeding Business Day. 
 “PBGC”
means the United States Pension Benefit Guaranty Corporation referred to and defined in ERISA and any successor entity performing similar functions. 

“Permits” means all permits, licenses, registrations, certificates, orders, approvals, authorizations, consents, waivers,
franchises, variances and similar rights issued by or obtained from any Governmental Authority or any other Person, including, without limitation, those relating to Environmental Laws. 

“Permitted Acquisition” means any Acquisition by the Borrower or any of its
wholly-owned Subsidiaries, by (i) purchase, merger, license or otherwise, of all or substantially all of the assets of, all of the Equity Interests of, or a business line or unit or a division of, any
Person or (ii) license arrangement for the rights to use, develop, market or otherwise commercialize any Patents, Trademarks, Copyrights or other Intellectual Property (other than ordinary course, over the counter software license
arrangements); provided that: 
 (a) immediately prior to, and immediately after giving effect thereto, no Default or
Event of Default shall have occurred and be continuing or would result therefrom; 

  
 -17- 

 (b) all transactions in connection therewith shall be consummated, in all
material respects, in accordance with all applicable Laws and in conformity in all material respects with all applicable Governmental Approvals; 

(c) in the case of the Acquisition of all of the Equity Interests of such Person, all of the Equity Interests (except for any
such securities in the nature of directors’ qualifying shares required pursuant to applicable Law) acquired, or otherwise issued by such Person or any newly formed Subsidiary of the Borrower in connection with such Acquisition, shall be owned
100% by an Obligor or any other Subsidiary, and the Borrower shall have taken, or caused to be taken, as of the date such Person becomes a Subsidiary of the Borrower, each of the actions set forth in Section 8.11, if applicable; 

(d) such Person (in the case of an Acquisition of Equity Interests) or assets (in the case of an Acquisition of assets or a
division) (i) shall be engaged or used, as the case may be, in the same business or lines of business in which the Borrower and/or its Subsidiaries are engaged or a business reasonably and substantially related or incidental thereto or
(ii) shall have a similar customer base as the Borrower and/or its Subsidiaries; 
 (e) the Borrower shall have provided
the Administrative Agent with at least ten (10) Business Days’ prior written notice of any such Acquisition, together with summaries, prepared in reasonable detail, of all due diligence conducted by or on behalf of the Borrower or the
applicable Subsidiary prior to such Acquisition; 
 (f) all of the assets or Equity Interests acquired in connection with
such Acquisition shall be of a U.S. Person; 
 (g) on a pro forma basis after giving effect to such Acquisition, the
Borrower shall be in compliance with the Minimum Liquidity covenant set forth in Section 8.15; and 
 (h) the
Acquisition shall have been approved by the board of directors or other governing body or controlling Person of the Person acquired or the Person from whom such assets or division is acquired. 

“Permitted Cash Equivalent Investments” means (a) marketable direct obligations issued or unconditionally
guaranteed by the United States or any agency or any State thereof having maturities of not more than two (2) years from the date of acquisition, (b) commercial paper with an average maturity of no more than one (1) year and having
the highest rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc. and (c) any money market funds or other investment vehicles whose principal investments are in investments described in
clauses (i) or (ii) above, and (d) investments permitted by the investment policy approved by the board of directors of Borrower, so long as Borrower provides written notice to the Lenders of any changes to the investment policy
delivered to the Lenders on the Closing Date and such changes will not adversely affect the Lenders in any material respect in the determination of the Lenders in their reasonable discretion. 

“Permitted Indebtedness” means any Indebtedness permitted under Section 9.01. 

  
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 “Permitted Investors” means those persons identified on Schedule 1.01B.

 “Permitted Licenses” are (a) licenses of
over-the-counter software that is commercially available to the public and (b) licenses for the use of Obligor Intellectual Property, in each case, entered into in
the Ordinary Course of Business or as otherwise may be approved by the applicable Obligors’ board of directors and so long as (i) no Event of Default has occurred and is continuing at the time of such license and (ii) such license
does not materially impair the Lenders from exercising their rights under any of the Loan Documents. 
 “Permitted Liens”
means any Liens permitted under Section 9.02. 
 “Permitted Priority Liens” means (a) Liens permitted under
Section 9.02(d), (e), (f) or (g); and (b) Liens permitted under Section 9.02(b); provided that such Liens are also of the type described in Section 9.02(d), (e), (f) or (g). 

“Permitted Refinancing” means, with respect to any Indebtedness permitted to be refinanced, extended, renewed or replaced
hereunder, any refinancings, extensions, renewals and replacements of such Indebtedness; provided that such refinancing, extension, renewal or replacement shall not (a) increase the outstanding principal amount of the Indebtedness being
refinanced, extended, renewed or replaced, (b) contain terms relating to outstanding principal amount, amortization, maturity, collateral security (if any) or subordination (if any), or other material terms that, taken as a whole, are less
favorable in any material respect to the Borrower and its Subsidiaries or the Lenders than the terms of any agreement or instrument governing the Indebtedness being refinanced, (c) have an applicable interest rate or equivalent yield that
exceeds the interest rate or equivalent yield of the Indebtedness being refinanced, (d) contain any new requirement to grant any Lien or to give any Guarantee that was not an existing requirement of the Indebtedness being refinanced and
(e) after giving effect to such refinancing, extension, renewal or replacement, no Default or Event of Default shall have occurred (or would reasonably be expected to occur) as a result thereof. 

“Person” means any individual, corporation, company, voluntary association, partnership, limited liability company, joint
venture, trust, unincorporated organization or Governmental Authority or other entity of whatever nature. 
 “PFIC” has the
meaning set forth in Section 8.01(j). 
 “Plan” means any employee pension benefit plan (other than a Multiemployer
Plan) subject to the provisions of Title IV of ERISA or Section 412 of the Code or Section 302 of ERISA, and in respect of which the Borrower or any ERISA Affiliate is (or, if such plan were terminated, would under Section 4069
of ERISA be deemed to be) an “employer” as defined in Section 3(5) of ERISA. 
 “Premium Event” has the
meaning set forth in Section 10.03. 
 “Prepayment Fee” has the meaning set forth in Section 3.03(a). 

  
 -19- 

 “Pro Rata Share” has the meaning set forth in Section 11.08. 

“Product” means any current or future product subject to any Product Development and Commercialization Activities by any
Obligor, including any such product currently in development or which may be developed, in each case related to Material Intellectual Property. 

“Product Agreement” means, with respect to any Product, any Contract, license, document, instrument, interest (equity or
otherwise) or the like under which one or more Persons grants or receives (a) any right, title or interest with respect to any Product Development and Commercialization Activities of such Product, or (b) any right to exclude any other
Person from engaging in, or otherwise restricting any right, title or interest as to, any Product Development and Commercialization Activities with respect to such Product, including any Contract with suppliers, manufacturers, distributors, clinical
research organizations, hospitals, group purchasing organizations, wholesalers, pharmacies or any other Person related to such entity. 

“Product Assets” means, with respect to any Product, (a) any and all rights, title and interest of the Obligors or any
of its Subsidiaries in any assets relating to such Product or any Product Development and Commercialization Activities with respect to such Product, (b) all Product Related Information with respect to such Product or any related Product
Development and Commercialization Activities, (c) any Product Agreement related to such Product or any such Product Development and Commercialization Activities, (d) any Intellectual Property, Regulatory Approvals and similar assets with
respect to such Product or any such Product Development and Commercialization Activities, and (e) all rights, title and interests in any other property, tangible or intangible, manifesting or otherwise in respect of such Product or any such
Product Development and Commercialization Activities, including, without limitation, inventory, accounts receivable or similar rights to receive money or payment pertaining thereto and all proceeds of the foregoing. 

“Product Authorizations” means any and all Regulatory Approvals (including all applicable supplements, amendments,
governmental price and reimbursement approvals and approvals of applications for regulatory exclusivity), clearances, licenses, notifications, registrations, safety or quality specifications and standards, or any other authorizations of any
applicable Regulatory Authority in each case necessary for the manufacturing, development, distribution, ownership, use, storage, import, export, transport, promotion, marketing, sale or other commercialization of any Product or for any Product
Development and Commercialization Activities with respect thereto in any country or jurisdiction, whether U.S. or non-U.S, including without limitation INDs, NDAs or similar applications. 

“Product Development and Commercialization Activities” means, with respect to any Product, any combination of research,
development, manufacture, import, use, sale, licensing, importation, storage, design, labeling, marketing, promotion, supply, distribution, testing, packaging, purchasing or other commercialization activities, receipt of payment in respect of any of
the foregoing (including, without limitation, in respect of licensing, royalty or similar payments), or any similar or other activities the purpose of which is to commercially exploit such Product. 

  
 -20- 

 “Product Related Information” means, with respect to any Product, all
books, records, lists, ledgers, files, manuals, correspondence, reports, plans, drawings and data (in any form or medium), and all techniques and other know-how, owned or possessed by the Borrower or any of
its Subsidiaries that are necessary or required for any Product Development and Commercialization Activities relating to such Product, including (a) brand materials, packaging and other trade dress, customer targeting and other marketing,
promotion and sales materials and information, referral, customer, supplier and other contact lists and information, product, business, marketing and sales plans, research, studies and reports, sales, maintenance and production records, training
materials and other marketing, sales and promotional information, (b) clinical data, information included or supporting any Product Authorization or other Regulatory Approval, any regulatory filings, updates, notices and correspondence
(including adverse event and other pharmacovigilance and other post-marketing reports and information, etc.), technical information, product development and operational data and records, and all other
documents, records, files, data and other information relating to product development, manufacture and use, (c) litigation and dispute records, and accounting records, (d) all documents, records and files relating to Intellectual Property,
including all correspondence from and to third parties (including Intellectual Property counsel and patent, trademark and other intellectual property registries, including the United States Patent and Trademark Office) not subject to attorney-client
privilege, and (e) all other information, techniques and know-how necessary or required in connection with the Product Development and Commercialization Activities for any Product. 

“Prohibited Payment” means any bribe, rebate, payoff, influence payment, kickback or other payment or gift of money or
anything of value (including meals or entertainment) to any officer, employee or ceremonial office holder of any government or instrumentality thereof, political party or supra-national organization (such as
the United Nations), any political candidate, any royal family member or any other person who is connected or associated personally with any of the foregoing that is prohibited under any Requirement of Law. 

“Property” of any Person means any property or assets, or interest therein, of such Person. 

“Proportionate Share” means, with respect to any Lender, the percentage obtained by dividing (i) the Loan Exposure of
such Lender then in effect by (ii) the aggregate Loan Exposure of all Lenders then in effect. 
 “Proposal Letter”
means the letter agreement, dated March 26, 2020, among the Borrower and Perceptive Advisors LLC, regarding the transactions contemplated hereby and the outline of proposed terms and conditions attached thereto. 

“Publicly Reporting Company” means an issuer generally subject to the public reporting requirements of the Exchange Act. 

“Qualified Equity Interest” means, with respect to any Person, any Equity Interest of such Person that is not a Disqualified
Equity Interest. 

  
 -21- 

 “Qualified Plan” means an employee benefit plan (as defined in
Section 3(3) of ERISA) other than a Multiemployer Plan (i) that is or was at any time maintained or sponsored by any Obligor or any ERISA Affiliate thereof or to which any Obligor or any ERISA Affiliate thereof has ever made, or was ever
obligated to make, contributions, and (ii) that is intended to be tax qualified under Section 401(a) of the Code. 

“Qualified Public Offering” shall mean the initial underwritten public offering of common Equity Interests of Borrower
pursuant to an effective registration statement filed with the United States Securities and Exchange Commission in accordance with the Securities Act of 1933, raising Net Cash Proceeds of at least $60,000,000. 

“Recipient” means any Lender or the Administrative Agent. 

“Redemption Date” has the meaning set forth in Section 3.03(a). 

“Redemption Price” has the meaning set forth in Section 3.03(a). 

“Register” has the meaning set forth in Section 13.05(d). 

“Regulation T” means Regulation T of the Board of Governors of the Federal Reserve System, as
amended. 
 “Regulation U” means Regulation U of the Board of Governors of the Federal Reserve
System, as amended. 
 “Regulation X” means Regulation X of the Board of Governors of the Federal
Reserve System, as amended. 
 “Regulatory Approvals” means any Governmental Approval relating to any Product or any
Product Development and Commercialization Activities related to such Product, including any Product Authorizations with respect thereto. 

“Regulatory Authority” means any Governmental Authority that is concerned with or has regulatory or supervisory oversight
with respect to any Product or any Product Development and Commercialization Activities relating to any Product, including the FDA and all equivalent Governmental Authorities, whether U.S. or non-U.S. 

“Representatives” has the meaning set forth in Section 13.17. 

“Requirement of Law” means, as to any Person, any Law applicable to or binding upon such Person or any of its Properties or
revenues. 
 “Resignation Effective Date” has the meaning set forth in Section 12.06(a). 

“Responsible Officer” of any Person means each of the president, chief executive officer and chief financial officer of such
Person. 

  
 -22- 

 “Restricted Payment” means any dividend or other distribution (whether in
cash, securities or other Property) with respect to any Equity Interest of the Borrower or any of its Subsidiaries, or any payment (whether in cash, securities or other Property), including any sinking fund or similar deposit, on account of the
purchase, redemption, retirement, acquisition, cancellation or termination of any such shares of capital stock of the Borrower or any of its Subsidiaries or any option, warrant or other right to acquire any such shares of capital stock of the
Borrower or any of its Subsidiaries. 
 “Restrictive Agreement” means any indenture, agreement, instrument or other binding
arrangement that prohibits, restricts or imposes any condition upon (a) the ability of the Borrower or any Subsidiary to create, incur or permit to exist any Lien upon any of its Property (other than (i) customary provisions in contracts
(including without limitation leases and in-bound licenses of Intellectual Property) restricting the assignment thereof, (ii) restrictions or conditions imposed by any agreement governing secured
Permitted Indebtedness permitted under Section 9.01(g), to the extent that such restrictions or conditions apply only to the Property securing such Indebtedness and (iii) software and other Intellectual Property licenses pursuant to which
the Borrower or a Subsidiary thereof is the licensee of the relevant software or Intellectual Property, as the case may be (in which case, any prohibition or limitation shall relate only to the assets or rights subject to the applicable license
and/or the license itself)), or (b) the ability of any Subsidiary to pay dividends or other distributions with respect to any shares of its Equity Interests or to make or repay loans or advances to the Borrower or any other Subsidiary or to
Guarantee Indebtedness of the Borrower or any other Subsidiary. 
 “Sanctions” means economic or financial sanctions,
requirements or trade embargoes imposed, administered or enforced from time to time by U.S. Governmental Authorities (including, but not limited to, OFAC, the U.S. Department of State and the U.S. Department of Commerce). 

“Sanctions Laws” means all laws, rules, regulations and requirements of any jurisdiction applicable to the Obligors or any
party to the Loan Documents concerning or relating to Sanctions, terrorism or money laundering. 
 “SEC” means United
States Securities and Exchange Commission. 
 “Securities Account” has the meaning set forth in the Security Agreement.

 “Securities Subsidiary” means C4T Securities Corp., a Massachusetts corporation. 

“Security Agreement” means the Security Agreement, dated as of the date hereof, in substantially the form of Exhibit G,
among the Obligors, the Lenders and the Administrative Agent, granting a security interest in the personal Property constituting Collateral thereunder in favor of the Administrative Agent for the benefit of the Lenders. 

“Security Documents” means, collectively, the Security Agreement, each Short-Form IP
Security Agreement, and each other security document, control agreement or financing statement executed to perfect Liens in favor of the Administrative Agent for the benefit of the Lenders. 

  
 -23- 

 “Short-Form IP Security
Agreements” means any short-form copyright, patent or trademark (as the case may be) security agreements, dated as of the date hereof entered into by one or more Obligors in favor of the
Administrative Agent for the benefit of the Lenders, each in form and substance satisfactory to the Administrative Agent. 

“Solvent” means, with respect to any Person at any time, that (a) the present fair saleable value of the Property of
such Person is greater than the total amount of liabilities (including contingent liabilities) of such Person, (b) the present fair saleable value of the Property of such Person is not less than the amount that will be required to pay the
probable liability of such Person on its debts as they become absolute and matured, and (c) such Person has not incurred and does not intend to, and does not believe that it will, incur debts or liabilities beyond such Person’s ability to
pay as such debts and liabilities mature. 
 “Sources and Uses Certificate” means a certificate, required to be delivered
pursuant to Section 6.01(e)(x), duly executed and completed by a Responsible Officer of the Borrower setting forth the sources and uses of the cash and equity proceeds to be used in connection with the Transactions. 

“Specified Pipeline Targets” means those pipelines identified as Ikaros, BRAF, BRD9 and RET. 

“Stated Maturity Date” means the fourth (4th) anniversary of the Closing
Date; provided that if any such date shall occur on a day that is not a Business Day, then the Stated Maturity Date shall be the next succeeding Business Day. 

“Subsidiary” means, with respect to any Person (the “parent”) at any time of determination, any other Person
of which more than 50% of the outstanding capital stock of such other Person having ordinary voting powers, determined on a fully diluted basis, is at the time directly or indirectly owned or controlled by the parent. Unless the context otherwise
specifically requires, the term “Subsidiary” shall be a reference to a Subsidiary of Borrower. 
 “Taxes” means
all present or future taxes, levies, imposts, duties, deductions, withholdings (including backup withholding), assessments, fees or other charges imposed by any Governmental Authority, including any interest, additions to tax or penalties applicable
thereto. 
 “Technical Information” means all trade secrets and other proprietary or confidential information, which may
include any proprietary information of a scientific, technical, or business nature in any form or medium, standards and specifications, conceptions, ideas, innovations, discoveries, Invention disclosures, all documented research, developmental,
demonstration or engineering work, data, plans, specifications, reports, summaries, experimental data, manuals, models, samples, know-how, technical information, systems, methodologies, computer programs or
information technology. 
 “Term Loans” means the Tranche A Term Loan and the Tranche B Term Loan. 

  
 -24- 

 “Title IV Plan” means an employee benefit plan (as
defined in Section 3(3) of ERISA) other than a Multiemployer Plan (i) that is or was at any time maintained or sponsored by any Obligor or any ERISA Affiliate thereof or to which any Obligor or any ERISA Affiliate thereof has ever made, or
was obligated to make, contributions, and (ii) that is or was subject to Section 412 of the Code, Section 302 of ERISA or Title IV of ERISA. 

“Trademarks” has the meaning set forth in the Security Agreement. 

“Tranche A Term Loan” means each loan advanced by a Lender pursuant to Section 2.01(a). For purposes of clarification,
any calculation of the aggregate outstanding principal amount of the Tranche A Term Loan on any date of determination shall mean the aggregate principal amount of the Tranche A Term Loan made pursuant to Section 2.01(a) that has not yet been
repaid as of such date. 
 “Tranche A Term Loan Commitment” means the commitment of a Lender to make or otherwise fund a
Tranche A Term Loan and “Tranche A Term Loan Commitments” means such commitments of all Lenders in the aggregate. The amount of each Lender’s Tranche A Term Loan Commitment, if any, is set forth on Schedule 1.01A. The
aggregate amount of the Tranche A Term Loan Commitments as of the Closing Date is $12,500,000. 
 “Tranche B Term Loan”
means each loan advanced by a Lender pursuant to Section 2.01(b). For purposes of clarification, any calculation of the aggregate outstanding principal amount of the Tranche B Term Loan on any date of determination shall mean the aggregate
principal amount of the Tranche B Term Loan made pursuant to Section 2.01(b) that has not yet been repaid as of such date. 

“Tranche B Term Loan Borrowing Date” means with respect to the Tranche B Term Loan, the Business Day on which all conditions
set forth in Section 6.02 have been satisfied or waived by the Lenders and the Tranche B Term Loan is made hereunder. 

“Tranche B Term Loan Commitment” means the commitment of a Lender to make or otherwise fund a Tranche B Term Loan and
“Tranche B Term Loan Commitments” means such commitments of all Lenders in the aggregate. The amount of each Lender’s Tranche B Term Loan Commitment, if any, is set forth on Schedule 1.01A. The aggregate amount of the
Tranche B Term Loan Commitments as of the Closing Date is $7,500,000. 
 “Tranche B Term Loan Commitment Termination Date”
means June 30, 2021. 
 “Transactions” means the execution, delivery and performance by each Obligor of this Agreement
and the other Loan Documents to which such Obligor is a party and the other transactions contemplated hereby and thereby, including disbursement and application of the proceeds of the Term Loans. 

“Unrestricted Cash” means the balance of unencumbered cash (other than cash encumbered by the Liens granted to the Lenders
pursuant to the Loan Documents) and Permitted Cash Equivalent Investments (which for greater certainty shall not include any undrawn credit lines), in each case, to the extent held in a Deposit Account subject to an account control agreement
reasonably satisfactory to the Administrative Agent. 

  
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 “U.S. Person” means a “United States person” within the meaning
of Section 7701(a)(30) of the Code. 
 “U.S. Tax Compliance Certificate” has the meaning set forth in
Section 5.03(f)(ii)(B)(3). 
 “Warrants” means the warrants to be delivered to the Administrative Agent pursuant to
Section 6.01(i) that, among other things, grants the holder thereof the right to purchase the number of shares of Series B Preferred Stock of the Borrower as indicated on the Warrant Shares table on Schedule 1.01A, as the Warrants may be
amended, replaced or otherwise modified pursuant to the terms thereof. 
 “Warrant Obligations” means, with respect to the
Borrower, all of its Obligations arising out of, under or in connection with, any Warrant. 
 “Withdrawal Liability” means,
at any time, any liability incurred (whether or not assessed) by any ERISA Affiliate and not yet satisfied or paid in full at such time with respect to any Multiemployer Plan pursuant to Section 4201 of ERISA. 

“Write-Down and Conversion Powers” means, with respect to any EEA Resolution
Authority, the write-down and conversion powers of such EEA Resolution Authority from time to time under the Bail-In Legislation for the applicable EEA Member Country,
which write-down and conversion powers are described in the EU Bail-In Legislation Schedule. 

Section 1.02. Accounting Terms and Principles. All accounting determinations required to be made pursuant hereto
shall, unless expressly otherwise provided herein, be made substantially in accordance with GAAP. If, after the date hereof, any change occurs in GAAP or in the application thereof (an “Accounting Change”) and
such change would cause any amount required to be determined for the purposes of the covenants to be maintained or calculated pursuant to Article 8 or 9 to be materially different than the amount that would be determined prior to such change,
then the Borrower will provide a detailed notice of such change (an “Accounting Change Notice”) to the Administrative Agent in conjunction with the next required delivery of financial statements pursuant to
Section 8.01. If the Borrower requests an amendment to any provision hereof to eliminate the effect of any Accounting Change occurring after the Closing Date or in the application thereof on the operation of such provision, regardless of
whether any Accounting Change Notice is given before or after such Accounting Change or in the application thereof, then the Administrative Agent and the Borrower agree that they will negotiate in good faith amendments to the provisions of this
Agreement that are directly affected by such Accounting Change with the intent of having the respective positions of the Administrative Agent and the Borrower after such Accounting Change conform as nearly as possible to their respective positions
as of the date of this Agreement and, until any such amendments have been agreed upon, (i) the provisions in this Agreement shall be calculated as if no such Accounting Change had occurred and (ii) the Borrower shall provide to the
Administrative Agent a written reconciliation in form and substance reasonably satisfactory to the Administrative Agent, between calculations of any baskets and other requirements hereunder before and after giving effect to such Accounting Change.

  
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 All components of financial calculations made to determine compliance with this Agreement
shall be adjusted to include or exclude, as the case may be, without duplication, such components of such calculations attributable to any Acquisition or disposition of assets consummated after the first day of the applicable period of determination
and prior to the end of such period, as determined in good faith by the Borrower based on assumptions expressed therein and that were reasonable based on the information available to the Borrower at the time of preparation of the Compliance
Certificate setting forth such calculations. 
 Section 1.03. Interpretation. For all purposes of this Agreement,
except as otherwise expressly provided herein or unless the context otherwise requires, (a) the terms defined in this Agreement include the plural as well as the singular and vice versa; (b) words importing gender include all genders;
(c) any reference to a Section, Article, Annex, Schedule or Exhibit refers to a Section or Article of, or Annex, Schedule or Exhibit to, this Agreement; (d) any reference to “this Agreement” refers to this Agreement, including
all Annexes, Schedules and Exhibits hereto, and the words herein, hereof, hereto and hereunder and words of similar import refer to this Agreement and its Annexes, Schedules and Exhibits as a whole and not to any particular Section, Article, Annex,
Schedule, Exhibit or any other subdivision; (e) references to days, months and years refer to calendar days, months and years, respectively; (f) all references herein to “include” or “including” shall be deemed to be
followed by the words “without limitation”; (g) the word “from” when used in connection with a period of time means “from and including” and the word “until” means “to but not including”; and
(h) accounting terms not specifically defined herein shall be construed substantially in accordance with GAAP (except for the term “property,” which shall be interpreted as broadly as possible, including, in any case, cash,
securities, other assets, rights under contractual obligations and permits and any right or interest in any property, except where otherwise noted). Unless otherwise expressly provided herein, references to organizational documents, agreements
(including the Loan Documents) and other contractual instruments shall be deemed to include all subsequent amendments, restatements, extensions, supplements and other modifications thereto permitted by the Loan Documents. 

Section 1.04. Divisions. For all purposes under the Loan Documents, in connection with any division or plan of
division under Delaware law (or any comparable event under a different jurisdiction’s laws): (a) if any asset, right, obligation or liability of any Person becomes the asset, right, obligation or liability of a different Person, then it
shall be deemed to have been transferred from the original Person to the subsequent Person and (b) if any new Person comes into existence, such new Person shall be deemed to have been organized on the first date of its existence by the holders
of its Equity Interests at such time. 

  
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 ARTICLE 2 

THE COMMITMENTS 

Section 2.01. Term Loans. 

(a) Tranche A Term Loan. 

(i) Subject to the terms and conditions of this Agreement and relying on the representations and warranties set forth herein,
each Lender, severally and not jointly, agrees to provide its share of the Tranche A Term Loan to the Borrower on the Closing Date in Dollars in a principal amount equal to such Lender’s Tranche A Term Loan Commitment. No Lender shall have an
obligation to make a Tranche A Term Loan in excess of such Lender’s Tranche A Term Loan Commitment. 
 (ii) The Borrower
may make one borrowing under the Tranche A Term Loan Commitment which shall be on the Closing Date. Subject to Sections 3.01 and 3.03, all amounts owed hereunder with respect to the Tranche A Term Loan shall be paid in full no later than the
Maturity Date. Each Lender’s Tranche A Term Loan Commitment shall terminate immediately and without further action on the Closing Date after giving effect to the funding of such Lender’s Tranche A Term Loan Commitment on such date. 

(b) Tranche B Term Loan. 

(i) Prior to the Tranche B Term Loan Commitment Termination Date, subject to the terms and conditions of this Agreement and
relying on the representations and warranties set forth herein, each Lender, severally and not jointly, agrees, at the request of the Borrower, to provide its share of the Tranche B Term Loan to the Borrower on the Tranche B Term Loan Borrowing Date
in Dollars in a principal amount equal to such Lender’s Tranche B Term Loan Commitment. No Lender shall have an obligation to make a Tranche B Term Loan in excess of such Lender’s Tranche B Term Loan Commitment. 

(ii) Subject to the terms and conditions of this Agreement (including Section 6.02), the Borrower shall deliver to the
Administrative Agent a fully executed Borrowing Notice no later than 5 p.m. (Eastern time) at least three (3) Business Days in advance of the proposed Tranche B Term Loan Borrowing Date. 

(iii) The Borrower may make one (1) borrowing under the Tranche B Term Loan Commitment which shall be on the Tranche B
Term Loan Borrowing Date. Subject to Sections 3.01 and 3.03, all amounts owed hereunder with respect to the Tranche B Term Loan shall be paid in full no later than the Maturity Date. Each Lender’s Tranche B Term Loan Commitment shall
terminate immediately and without further action on the Tranche B Term Loan Borrowing Date after giving effect to the funding of such Lender’s Tranche B Term Loan Commitment on such date. 

  
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 (c) Any principal amount of the Term Loan borrowed under Section 2.01(a) or 2.01(b)
hereof and subsequently repaid or prepaid may not be reborrowed. 
 Section 2.02. Proportionate Shares. Each Term
Loan shall be made, and all participations purchased, by the Lenders simultaneously and proportionately to their respective Proportionate Shares, it being understood that no Lender shall be responsible for any default by any other Lender in such
other Lender’s obligation to make a Term Loan hereunder or purchase a participation required hereby nor shall the Commitment of any Lender be increased or decreased as a result of a default by any other Lender in such other Lender’s
obligation to make a Term Loan requested hereunder or purchase a participation required hereby. 
 Section 2.03.
Fees. On the Closing Date, the Borrower shall pay out of the proceeds of the Tranche A Term Loan advanced by the Lenders on the Closing Date a non-refundable fee in the amount of $300,000 (the
“Closing Fee”). Such payment shall be in addition to such fees, costs and expenses due and payable pursuant to Section 13.03. 

Section 2.04. Notes. Upon the request of any Lender, the Borrower shall prepare, execute and deliver to such Lender
one or more promissory note(s) evidencing the portion of the Term Loans payable to such Lender (or if requested by it, to it and its registered assigns) in the form attached hereto as Exhibit B (each, a “Note”).

 Section 2.05. Use of Proceeds. The Borrower shall use the proceeds of the Term Loans (a) for general
working capital purposes and corporate purposes not expressly prohibited hereunder, (b) to refinance certain existing Indebtedness on the Closing Date and (c) to pay, in accordance with the Sources and Uses Certificate, fees, costs and
expenses incurred in connection with the Transactions. 
 ARTICLE 3 

PAYMENTS OF PRINCIPAL AND INTEREST 

Section 3.01. Repayment. There will be no scheduled repayments of principal on the Term Loans prior to the thirtieth
(30th) month anniversary of the Closing Date. Commencing with the Payment Date occurring immediately after the thirtieth (30th) month
anniversary of the Closing Date, the Borrower shall on each Payment Date make a repayment of the Term Loans in an amount equal to 2.00% of the initial principal amount of the Term Loans drawn under Section 2.01. The entire outstanding principal
amount of the Term Loans will be due and payable on the Maturity Date. 
 Section 3.02. Interest. 

(a) Interest Generally. The Borrower agrees to pay to the Lenders interest in cash on the outstanding principal amount of the Term Loans
for each Interest Period at a rate per annum equal to the sum of (i) LIBOR plus (ii) the Applicable Margin. 

  
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 (b) LIBOR Not Determinable. If on or before the day on which LIBOR is to be
determined, the Majority Lenders determine that (i) LIBOR cannot be determined for any reason, (ii) LIBOR will not adequately and fairly reflect the cost of maintaining the Term Loans or (iii) Dollar deposits in the principal amount
of the Term Loans are not available in the London interbank market, the Majority Lenders shall, as soon as practicable thereafter, give written notice of such determination to the Borrower and the Administrative Agent. Upon any such determination,
LIBOR shall be LIBOR as of the end of the immediately preceding Interest Period and shall at all times thereafter bear interest at LIBOR as of the end of the immediately preceding Interest Period. Each determination by the Majority Lenders hereunder
shall be conclusive and binding absent manifest error. 
 (c) Replacement to LIBOR. If at any time the Administrative Agent determines
(which determination shall be conclusive absent manifest error) that (i) the circumstances set forth in clause (b)(i) of this Section have arisen and such circumstances are unlikely to be temporary or (ii) the circumstances set
forth in clause (b)(i) of this Section have not arisen but the supervisor for the administrator of LIBOR has made a public statement identifying a specific date after which LIBOR shall no longer be used for determining interest rates for
loans, then the Administrative Agent and the Borrower shall endeavor to establish an alternate rate of interest to LIBOR that gives due consideration to the then-prevailing market convention for determining a rate of interest for syndicated loans in
the United States at such time, and shall enter into an amendment to this Agreement to reflect such alternate rate of interest and such other related changes to this Agreement as may be applicable; provided that, if such alternate rate of
interest shall be less than 1.75%, such rate shall be deemed to be 1.75% for the purposes of this Agreement. Notwithstanding anything to the contrary in Section 13.04, such amendment shall become effective without any further action or consent
of any other party to this Agreement so long as the Administrative Agent shall not have received, within five (5) Business Days of the date notice of such alternate rate of interest is provided to the Lenders, a written notice from the Majority
Lenders stating that such Lenders object to such amendment. 
 (d) Default Interest. Notwithstanding the foregoing, upon the
occurrence and during the continuance of any Event of Default, the Applicable Margin on the principal amount of the Term Loans outstanding hereunder shall automatically increase by four percent (4.00%) per annum (the interest rate, as increased
pursuant to this Section 3.02(d), being the “Default Rate”). If any Obligation is not paid when due under any applicable Loan Document, the amount thereof shall accrue interest at the Default Rate. Payment or acceptance of the
increased rates of interest provided for in this Section 3.02(d) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of the
Administrative Agent or any Lender. 
 (e) Payment Dates. Accrued interest on the Term Loans shall be payable in arrears on each
Payment Date with respect to the most recently completed Interest Period in cash, and upon the payment or prepayment of the Term Loans (on the principal amount being so paid or prepaid); provided that interest payable at the Default Rate
shall be payable from time to time on demand by the Majority Lenders. 

  
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 (f) Maximum Rate. Notwithstanding any other provision of this Agreement, in no event
will any interest or rates referred to herein exceed the maximum interest rate permitted by applicable Law. If such maximum interest rate would be exceeded by the terms hereof, the rates of interest payable hereunder will be reduced to the extent
necessary so that such rates (together with any fees or other amounts which are construed by a court of competent jurisdiction to be interest or in the nature of interest) equal the maximum interest rate permitted by applicable Law and any
overpayment of interest received by the Lenders before such rates are so construed will be applied, forthwith after determination of such overpayment, to pay all then outstanding interest, and thereafter to pay outstanding principal. 

Section 3.03. Prepayments. 

(a) Optional Prepayments. The Borrower shall have the right to optionally prepay in whole or in part (in a minimum amount of $500,000
and integral multiples of $100,000 in excess of that amount for each partial prepayment) the outstanding principal amount of the Term Loans on any Business Day (a “Redemption Date”) for an amount equal to the sum of
(i) the aggregate principal amount of the Term Loans being prepaid, (ii) any accrued but unpaid interest in respect of the aggregate principal amount of the Term Loans being prepaid and (iii) a prepayment fee equal to the Multiple on
Invested Capital on the aggregate principal amount of the Term Loans being prepaid on such date (the “Prepayment Fee” and such aggregate amount, the “Redemption Price”). 

(b) Mandatory Prepayment. In the event of any Casualty Event, the Borrower shall prepay the Term Loans plus a Prepayment Fee on the
principal amount of the Term Loans being prepaid (calculated in accordance with the definition of “Multiple on Invested Capital”, it being agreed that the relevant payment date shall be deemed to be the “Redemption Date” for
purposes of such calculation), plus any accrued but unpaid interest and fees then due and owing, in an amount equal to 100% of the Net Cash Proceeds received by the Obligors with respect thereto; provided, however, so long as no Default or
Event of Default has occurred and is continuing, within one hundred eighty (180) days after receipt of such Net Cash Proceeds, the Borrower may apply the Net Cash Proceeds of any casualty policy up to $500,000 with respect to any loss, but not
exceeding $1,000,000 in the aggregate for all losses under all casualty policies during the term of this Agreement, toward the replacement or repair of destroyed or damaged property; provided, further, that any such replaced or repaired
property shall be Collateral in which the Administrative Agent for the benefit of the Lenders has been granted a security interest under the Security Documents. 

(c) Prepayment Fee. Payment of any Prepayment Fee under this Section 3.03 constitutes liquidated damages, not unmatured interest or
a penalty, as the actual amount of damages to the Lenders as a result of the relevant triggering event, prepayment or repayment would be impracticable and extremely difficult to ascertain. Accordingly, the Prepayment Fee hereunder is provided by
mutual agreement of the Borrower and the Lenders as a reasonable estimation and calculation of such actual lost profits and other actual damages of the Lenders. Without limiting the generality of the foregoing, it is understood and agreed that upon
the occurrence of any Premium Event, the Prepayment Fee shall be automatically and immediately due and payable as though any prepaid or repaid portion of the Term Loans were voluntarily prepaid as of such date 

  
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 and shall constitute part of the Obligations secured by the Collateral. The Prepayment Fee shall also be
automatically and immediately due and payable if the Term Loans are satisfied or released by foreclosure (whether by power of judicial proceeding or otherwise), deed in lieu of foreclosure or by any other means. THE BORROWER HEREBY EXPRESSLY WAIVES
(TO THE FULLEST EXTENT IT MAY LAWFULLY DO SO) THE PROVISIONS OF ANY PRESENT OR FUTURE STATUTE OR OTHER LAW THAT PROHIBITS OR MAY PROHIBIT THE COLLECTION OF THE FOREGOING APPLICABLE PREMIUM IN CONNECTION WITH ANY SUCH EVENTS. The Borrower and the
other Obligors expressly agree (to the fullest extent it and they may lawfully do so) that with respect to the Prepayment Fee payable under the terms of this Agreement: (i) the Prepayment Fee is reasonable and is the product of an arm’s
length transaction between sophisticated business parties, ably represented by counsel; (ii) the Prepayment Fee shall be payable notwithstanding the then-prevailing market rates at the time payment is made; (iii) there has been a course of
conduct between the Lenders and the Obligors giving specific consideration in this transaction for such agreement to pay the Prepayment Fee; and (iv) the Obligors shall be estopped hereafter from claiming differently than as agreed to in this
paragraph. The Obligors expressly acknowledge that their agreement to pay the Prepayment Fee as herein described is a material inducement to the Lenders to provide the Commitments and to make the Term Loans. 

ARTICLE 4 

PAYMENTS, ETC. 

Section 4.01. Payments. 

(a) Payments Generally. Each payment of principal, interest and other amounts to be made by the Obligors under this Agreement or any
other Loan Document shall be made in Dollars, in immediately available funds, without deduction, set off or counterclaim, to the deposit account of the Administrative Agent, for the account of the respective Lenders to which such payment is owed,
not later than 2:00 p.m. (Eastern time) on the date on which such payment is due (each such payment made after such time on such due date to be deemed to have been made on the next succeeding Business Day). 

(b) Application of Payments Following an Event of Default. Proceeds of all payments received following the occurrence and continuance
of an Event of Default shall be applied in the following order of priority, with proceeds being applied to a succeeding level of priority only if amounts owing pursuant to the immediately preceding level of priority have been paid in full in cash:

 (i) first, to the payment of any unpaid costs or expenses referred to in Section 13.03(a) then due and owing;

 (ii) second, to the payment of any accrued and unpaid interest and any fees (other than the Prepayment Fee) then
due and owing; 

  
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 (iii) third, to the payment of unpaid principal of the Term Loans on
a pro rata basis; 
 (iv) fourth, to the payment of any Prepayment Fee then due and payable; 

(v) fifth, in reduction of the Borrower’s obligation to pay any Claims or Losses referred to in
Section 13.03(b) then due and owing; and 
 (vi) sixth, to the Borrower or such other Persons as may lawfully be
entitled to or directed by the Borrower to receive the remainder. 
 (c) Application of Prepayments. Proceeds of any prepayment made
pursuant to clauses 3.03(a) or 3.03(b) above shall be applied in the following order of priority, with proceeds being applied to a succeeding level of priority only if amounts owing pursuant to the immediately preceding level of priority have
been paid in full in cash: 
 (i) first, to the payment of any unpaid costs or expenses referred to in
Section 13.03(a) then due and owing; 
 (ii) second, to the payment of any accrued and unpaid interest and any
fees (other than the Prepayment Fee) then due and owing; 
 (iii) third, to the payment of any Prepayment Fee then due
and payable; and 
 (iv) fourth, to the payment of unpaid principal of the Term Loans on a pro rata basis. 

Unless otherwise directed by the Majority Lenders, all payments of principal, interest and fees under this Agreement and the other Loan Documents shall be
made by the Obligors to the Lenders pro rata in accordance with the Lenders’ respective Proportionate Shares of such payments. 
 (d)
Non-Business Days. Except in the case of any payment to be made on any Payment Date, if the due date of any payment under this Agreement (whether in respect of principal, interest, fees, costs or
otherwise, but excluding the Stated Maturity Date) would otherwise fall on a day that is not a Business Day, such date shall be extended to the next succeeding Business Day, and, in the case of any payment accruing interest, interest thereon shall
be payable for the period of such extension. 
 Section 4.02. Computations. All computations of interest
and fees hereunder shall be computed on the basis of a year of 360 days and actual days elapsed during the period for which payable. 

Section 4.03. Notices. Each notice of optional prepayment shall be effective only if received by the Lenders
not later than 2:00 p.m. (Eastern time) on the date three (3) Business Days prior to the date of prepayment. Each notice of optional prepayment shall specify the amount to be prepaid and the date of prepayment. 

  
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 Section 4.04.
Set-Off. 
 (a) Set-Off Generally.
Upon the occurrence and during the continuance of any Event of Default, the Administrative Agent, the Lenders and each of their respective Affiliates are hereby authorized at any time and from time to time, to the fullest extent permitted by Law, to
set off and apply any and all deposits (general or special, time or demand, provisional or final) at any time held and other indebtedness at any time owing by the Lenders or such Affiliates to or for the credit or the account of any Obligor against
any and all of the Obligations, whether or not the Lenders shall have made any demand and although such Obligations may be unmatured. The Lenders agree promptly to notify the Borrower after any such set-off
and application, provided that the failure to give such notice shall not affect the validity of such set-off and application. The rights of the Lenders and their respective Affiliates under this
Section 4.04 are in addition to other rights and remedies (including other rights of set-off) that the Lenders and their respective Affiliates may have. 

(b) Exercise of Rights Not Required. Nothing contained herein shall require the Administrative Agent, the Lenders or any of their
respective Affiliates to exercise any such right or shall affect the right of such Persons to exercise, and retain the benefits of exercising, any such right with respect to any other indebtedness or obligation of any Obligor. 

ARTICLE 5 

YIELD PROTECTION, ETC. 

Section 5.01. Additional Costs. 

(a) Change in Requirements of Law Generally. If, on or after the date hereof, the adoption of any Requirement of Law, or any change in
any Requirement of Law, or any change in the interpretation or administration thereof by any court or other Governmental Authority charged with the interpretation or administration thereof, or compliance by any Lender (or its lending office) with
any request or directive (whether or not having the force of law) of any such Governmental Authority, shall impose, modify or deem applicable any reserve (including any such requirement imposed by the Board of Governors of the Federal Reserve
System), special deposit, contribution, insurance assessment or similar requirement, in each case that becomes effective after the date hereof, against assets of, deposits with or for the account of, or credit extended by, a Lender (or its lending
office) or shall impose on a Lender (or its lending office) any other condition affecting the Term Loans or the Commitment, not as a result of any action or inaction on the part of such Lender, and the result of any of the foregoing is to increase
the cost to any Lender of making or maintaining its portion of the Term Loans, or to reduce the amount of any sum received or receivable by any Lender under this Agreement or any other Loan Document, by an amount reasonably deemed by such Lender in
good faith to be material (other than (i) Indemnified Taxes, (ii) Taxes described in clauses (b) through (d) of the definition of “Excluded Taxes” and (iii) Connection Income Taxes), then the Borrower shall
promptly pay to such Lender on demand such additional amount or amounts as will compensate such Lender for such increased cost or reduction. Notwithstanding anything herein to the contrary, (x) the
Dodd-Frank Wall Street Reform and Consumer Protection Act and all requests, rules, guidelines or directives thereunder 

  
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 or issued in connection therewith and (y) all requests, rules, guidelines or directives promulgated by
the Bank for International Settlements, the Basel Committee on Banking Supervision (or any successor or similar authority) or the United States or foreign regulatory authorities, in each case pursuant to Basel III, shall in each case be deemed
to constitute a change in Requirements of Law for all purposes of this Section 5.01, regardless of the date enacted, adopted or issued. 

(b) Change in Capital Requirements. If a Lender shall have determined that, on or after the date hereof, the adoption of any Requirement
of Law regarding capital adequacy, or any change therein, or any change in the interpretation or administration thereof by any Governmental Authority charged with the interpretation or administration thereof, or any request or directive regarding
capital adequacy (whether or not having the force of law) of any such Governmental Authority, in each case that becomes effective after the date hereof, has or would have the effect of reducing the rate of return on capital of a Lender (or its
parent) as a consequence of a Lender’s obligations hereunder or the Term Loans to a level below that which a Lender (or its parent) could have achieved but for such adoption, change, request or directive by an amount reasonably deemed by it to
be material, then the Borrower shall pay to such Lender on demand such additional amount or amounts as will compensate such Lender (or its parent) for such reduction. 

(c) Notification by Lender. The Lenders will promptly notify the Borrower of any event of which it has knowledge, occurring after the
date hereof, which will entitle a Lender to compensation pursuant to this Section 5.01, including a calculation in reasonable detail of such compensation. Before giving any such notice pursuant to this Section 5.01(c) such Lender shall
designate a different lending office if such designation (x) will, in the reasonable judgment of such Lender, avoid the need for, or reduce the amount of, such compensation and (y) will not, in the reasonable judgment of such Lender, be
materially disadvantageous to such Lender. A certificate of the Lender claiming compensation under this Section 5.01, setting forth the amount or amounts to be paid to it hereunder, shall be conclusive and binding on the Borrower in the absence
of manifest error. 
 Section 5.02. Illegality. Notwithstanding any other provision of this Agreement, in
the event that on or after the date hereof the adoption of or any change in any Requirement of Law or in the interpretation or application thereof by any competent Governmental Authority shall make it unlawful for a Lender or its lending office to
make or maintain the Term Loans (and, in the opinion of such Lender, the designation of a different lending office would either not avoid such unlawfulness or would be disadvantageous to such Lender), then such Lender shall promptly notify the
Borrower thereof following which (a) the Lender’s Commitment shall be suspended until such time as such Lender may again make and maintain the Term Loans hereunder and (b) if such Requirement of Law shall so mandate, the Term Loans
shall be prepaid by the Borrower on or before such date as shall be mandated by such Requirement of Law in an amount equal to the Redemption Price applicable on the date of such prepayment in accordance with Section 3.03(a). 

  
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 Section 5.03. Taxes. 

(a) Payments Free of Taxes. Any and all payments on account of any Obligation shall be made without deduction or withholding for any
Taxes, except as required by applicable Law. If any applicable Law requires the deduction or withholding of any Tax from any such payment by an Obligor, then such Obligor shall be entitled to make such deduction or withholding and shall timely pay
the full amount deducted or withheld to the relevant Governmental Authority in accordance with applicable Law and, if such Tax is an Indemnified Tax, then the sum payable by such Obligor shall be increased as necessary so that after such deduction
or withholding for Indemnified Taxes has been made (including such deductions and withholdings for Indemnified Taxes applicable to additional sums payable under this Section 5.03) the applicable Recipient receives an amount equal to the sum it
would have received had no such deduction or withholding for Indemnified Taxes been made. For purposes of this Section, the term “applicable Law” includes FATCA. 

(b) Payment of Other Taxes by the Borrower. The Borrower shall timely pay to the relevant Governmental Authority in accordance with
applicable Law, or at the option of the Administrative Agent, timely reimburse it for, Other Taxes. 
 (c) Evidence of Payments. As
soon as practicable after any payment of Taxes by the Borrower to a Governmental Authority, as a withholding Tax pursuant to this Section 5.03, the Borrower shall deliver to the Administrative Agent the original or a certified copy of a receipt
issued by such Governmental Authority evidencing such payment, or a copy of the return reporting such payment or other evidence of such payment reasonably satisfactory to the Administrative Agent. 

(d) Indemnification. The Borrower shall reimburse and indemnify each Recipient, within ten (10) days after demand therefor, for the
full amount of any Indemnified Taxes (including Indemnified Taxes imposed or asserted on or attributable to amounts payable under this Section 5.03) payable or paid by such Recipient or required to be withheld or deducted from a payment to such
Recipient and any reasonable expenses arising therefrom or with respect thereto, whether or not such Indemnified Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. A certificate as to the amount of such
payment or liability delivered to the Borrower by a Lender (with a copy to the Administrative Agent), or by the Administrative Agent on its own behalf or on behalf of a Lender, shall be conclusive absent manifest error. 

(e) Indemnification by the Lenders. Each Lender shall severally indemnify the Administrative Agent, within ten (10) days after
demand therefor, for (i) any Indemnified Taxes attributable to such Lender (but only to the extent that the Borrower has not already indemnified the Administrative Agent for such Indemnified Taxes and without limiting the obligation of any
Borrower to do so), and (ii) any Taxes attributable to such Lender, in each case, that are payable or paid by the Administrative Agent in connection with any Loan Document, and any reasonable expenses arising therefrom or with respect thereto,
whether or not such Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. A certificate as to the amount of such payment or liability delivered to any Lender by the Administrative Agent shall be conclusive
absent manifest error. Each Lender hereby authorizes the Administrative Agent to set off and apply any and all amounts at any time owing to such Lender under any Loan Document or otherwise payable by the Administrative Agent to such Lender from any
other source against any amount due to the Administrative Agent under this paragraph (e). 

  
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 (f) Status of Lenders. (i) Any Lender that is entitled to an exemption from, or
reduction of withholding Tax with respect to payments made under any Loan Document shall deliver to the Borrower and the Administrative Agent, at the time or times reasonably requested by the Borrower or the Administrative Agent, such properly
completed and executed documentation reasonably requested by the Borrower or the Administrative Agent as will permit such payments to be made without withholding or at a reduced rate of withholding. In addition, any Lender, if reasonably requested
by the Borrower or the Administrative Agent, shall deliver such other documentation prescribed by applicable Law or as reasonably requested by the Borrower or the Administrative Agent as will enable the Borrower or the Administrative Agent to
determine whether or not such Lender is subject to backup withholding or information reporting requirements. Notwithstanding anything to the contrary in the preceding two sentences, the completion, execution and submission of such documentation
(other than such documentation set forth in Section 5.03(f)(ii)(A), (B) or (D)) shall not be required if in the Lender’s reasonable judgment such completion, execution or submission would subject such Lender to any material unreimbursed
cost or expense or would materially prejudice the legal or commercial position of such Lender. 
 (ii) Without limiting the generality of the
foregoing: 
 (A) any Lender that is a U.S. Person shall deliver to the Borrower and the Administrative Agent on or prior to
the date on which such Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Borrower or the Administrative Agent), duly completed, valid, executed copies of IRS Form W-9 (or successor form) certifying that such Lender is exempt from U.S. Federal backup withholding Tax; 

(B) any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to the Borrower and the Administrative
Agent (in such number of copies as shall be requested by the Recipient) on or prior to the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Borrower and the
Administrative Agent), whichever of the following is applicable: 
 (1) in the case of a Foreign Lender claiming the benefits
of an income Tax treaty to which the United States is a party (x) with respect to payments of interest under any Loan Document, duly completed, valid executed copies of IRS Form W-8BEN (or successor form)
or IRS Form W-8BEN-E (or successor form) establishing an exemption from, or reduction of, U.S. Federal withholding Tax pursuant to the “interest” article of
such Tax treaty and (y) with respect to any other applicable payments under any Loan Document, duly completed, valid, executed originals of IRS Form W-8BEN (or successor form) or IRS Form W-8BEN-E (or successor form) establishing an exemption from, or reduction of, U.S. Federal withholding Tax pursuant to the “business profits” or “other
income” article of such Tax treaty; 
 (2) duly completed, valid, executed copies of IRS Form W-8ECI (or successor form); 

  
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 (3) in the case of a Foreign Lender claiming the benefits of the exemption
for portfolio interest under Section 881(c) of the Code, (x) a certificate substantially in the form of Exhibit C to the effect that such Foreign Lender is not a “bank” within the meaning of Section 881(c)(3)(A) of the
Code, a “10 percent shareholder” of the applicable Borrower within the meaning of Section 881(c)(3)(B) of the Code, or a “controlled foreign corporation” described in Section 881(c)(3)(C) of the Code (a
“U.S. Tax Compliance Certificate”) and (y) executed copies of IRS Form W-8BEN (or successor form) or IRS Form
W-8BEN-E (or successor form); or 
 (4) to
the extent a Foreign Lender is not the beneficial owner, duly completed, valid, executed copies of IRS Form W-8IMY (or successor form), accompanied by IRS Form W-8ECI
(or successor form), IRS Form W-8BEN (or successor form), IRS Form W-8BEN-E (or successor form), a U.S. Tax Compliance
Certificate, IRS Form W-9 (or successor form), and/or other certification documents from each beneficial owner, as applicable; provided that if the Foreign Lender is a partnership and one or more
direct or indirect partners of such Foreign Lender are claiming the portfolio interest exemption, such Foreign Lender may provide a U.S. Tax Compliance Certificate on behalf of each such direct and indirect partner; 

(C) any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to the Borrower and the Administrative
Agent (in such number of copies as shall be requested by the Recipient) on or prior to the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Borrower or the
Administrative Agent), executed copies of any other form prescribed by applicable Law as a basis for claiming exemption from or a reduction in U.S. Federal withholding Tax, duly completed, together with such supplementary documentation as may be
prescribed by applicable Law to permit the Borrower or the Administrative Agent to determine the withholding or deduction required to be made; and 

(D) if a payment made to a Lender under any Loan Document would be subject to U.S. federal withholding Tax imposed by FATCA if
such Lender were to fail to comply with the applicable reporting requirements of FATCA (including those contained in Section 1471(b) or 1472(b) of the Code, as applicable), such Lender shall deliver to the Borrower and the Administrative Agent
at the time or times prescribed by Law and at such time or times reasonably requested by the Borrower or the Administrative Agent such documentation prescribed by applicable Law (including as prescribed by Section 1471(b)(3)(C)(i) of the Code)
and such additional documentation reasonably requested by the Borrower or the Administrative Agent as may be necessary for the Borrower and the Administrative Agent to comply with its obligations under FATCA and to determine that such Lender has
complied with such Lender’s obligations under FATCA or to determine the amount, if any, to deduct and withhold from such payment. Solely for purposes of this clause (D), “FATCA” shall include any amendments made to FATCA after
the date of this Agreement. 

  
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 Each Recipient agrees that if any form or certification it previously delivered expires or becomes obsolete
or inaccurate in any respect, it shall promptly update such form or certification or promptly notify the Borrower and the Administrative Agent in writing of its legal inability to do so. 

(g) Treatment of Certain Refunds. If any party to this Agreement determines, in its sole discretion exercised in good faith, that it has
received a refund of any Taxes as to which it has been indemnified pursuant to this Section 5.03 (including by the payment of additional amounts pursuant to this Section 5.03), it shall pay to the indemnifying party an amount equal to such
refund (but only to the extent of indemnity payments made under this Section with respect to the Taxes giving rise to such refund), net of all out-of-pocket expenses
(including Taxes) of such indemnified party and without interest (other than any interest paid by the relevant Governmental Authority with respect to such refund). Such indemnifying party, upon the written request of such indemnified party, shall
repay to such indemnified party the amount paid over pursuant to this paragraph (plus any penalties, interest or other charges imposed by the relevant Governmental Authority) in the event that such indemnified party is required to repay such refund
to such Governmental Authority. Notwithstanding anything to the contrary in this Section 5.03(g), in no event will the indemnified party be required to pay any amount to an indemnifying party pursuant to this Section 5.03(g) the payment of
which would place the indemnified party in a less favorable net after-Tax position than the indemnified party would have been in if the Tax subject to indemnification and giving rise to such refund had not
been deducted, withheld or otherwise imposed and the indemnification payments or additional amounts giving rise to such refund had never been paid. This Section 5.03(g) shall not be construed to require any indemnified party to make available
its Tax returns (or any other information relating to its Taxes that it deems confidential) to the indemnifying party or any other Person. 

(h) Mitigation Obligations. If the Borrower is required to pay any Indemnified Taxes or additional amounts to any Lender or to any
Governmental Authority for the account of any Lender pursuant to Section 5.01 or this Section 5.03, then such Lender shall (at the request of the Borrower) use commercially reasonable efforts to designate a different lending office for
funding or booking its Term Loans hereunder or to assign and delegate its rights and obligations hereunder to another of its offices, branches or Affiliates if, in the sole reasonable judgment of such Lender, such designation or assignment and
delegation would (i) eliminate or reduce amounts payable pursuant to Section 5.01 or this Section 5.03, as the case may be, in the future, (ii) not subject such Lender to any unreimbursed cost or expense and (iii) not
otherwise be disadvantageous to such Lender. The Borrower hereby agrees to pay all reasonable costs and expenses incurred by any Lender in connection with any such designation or assignment and delegation. 

(i) Survival. Each party’s obligations under this Article 5 shall survive the resignation or replacement of the Administrative
Agent or any assignment of rights by, or the replacement of, a Lender, the termination of the Commitments and the repayment, satisfaction or discharge of all Obligations under any Loan Document. 

  
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 Section 5.04. Delay in Requests. Failure or delay on the part of
any Lender to demand compensation pursuant to this Article 5 shall not constitute a waiver of such Lender’s right to demand such compensation; provided that the Borrower shall not be required to compensate a Lender pursuant to this
Section for any increased costs incurred or reductions suffered more than six (6) months prior to the date that such Lender notifies the Borrower of the change in Law giving rise to such increased costs or reductions, and of such Lender’s
intention to claim compensation therefor (except that, if the change in Law giving rise to such increased costs or reductions is retroactive, then the six-month period referred to above shall be extended to
include the period of retroactive effect thereof). 
 ARTICLE 6 

CONDITIONS PRECEDENT 

Section 6.01. Conditions to Tranche A Term Loan; Closing Date. The obligation of each Lender to make the
Tranche A Term Loan on the Closing Date shall not become effective until the following conditions precedent shall have been reasonably satisfied or waived in writing by the Lenders (which satisfaction or waiver may be made simultaneously with the
making of the Tranche A Term Loan hereunder): 
 (a) Organization and Capitalization. The organizational structure and
capitalization of the Obligors, after giving effect to the Transactions, as set forth on Schedule 7.20 shall be satisfactory to the Lenders. 

(b) Terms of Material Agreements. The Lenders shall be satisfied in their sole discretion with the terms and conditions
of all of the Obligors’ Material Agreements, including without limitation, the Material Agreements that are directly or indirectly associated with Product manufacturing, distribution and payment of royalties by any Obligor. 

(c) No Law Restraining Transactions. No applicable Law or regulation shall restrain, prevent or, in the reasonable
judgment of the Lenders, impose materially adverse conditions upon the Transactions. 
 (d) Lien Searches. The Lenders
shall be satisfied with Lien searches regarding the Obligors made prior to the Closing Date. 
 (e) Documentary
Deliveries. The Lenders shall have received the following documents, each of which shall be in form and substance satisfactory to the Lenders: 

(i) Agreement. This Agreement duly executed and delivered by the Borrower and each of the other parties hereto. 

(ii) Security Documents. (A) The Security Documents, including, without limitation, the Security Agreement, each Short-Form IP Security Agreement, account control agreements and financing statements, each in form and substance satisfactory to the Lenders and duly executed and delivered by each of the Obligors. 

  
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 (B) The Collateral Questionnaire, duly executed and delivered by a
Responsible Officer of the Borrower, substantially in the form of Exhibit H hereto and otherwise in form and substance satisfactory to the Lenders. 

(C) Without limitation, all other documents and instruments reasonably required to perfect the Lenders’ Lien on, and
security interest in, the Collateral required to be delivered on or prior to the Closing Date shall have been duly executed and delivered and be in proper form for filing, and shall create in favor of the Lenders, a perfected Lien on, and security
interest in, the Collateral, subject to no Liens other than Permitted Liens. 
 (D) The Borrower shall have executed and
delivered a landlord personal property collateral access agreement executed by the landlord of the leasehold property located at 490 Arsenal Way, Suite 200, Watertown, MA 02472 and by the Borrower. 

(iii) Note. Any Notes requested in accordance with Section 2.04. 

(iv) Approvals. The Borrower shall certify that all Regulatory Approvals have been made or obtained, and all material
licenses, consents, authorizations and approvals of, and notices to and filings and registrations with, any Governmental Authority (including all foreign exchange approvals) in connection with the Transactions have been made or obtained, and all
material third-party consents and approvals, necessary in connection with the execution, delivery and performance by the Obligors of the Loan Documents and the Transactions have been obtained. 

(v) Organizational Documents. (A) Certified copies of the Organizational Documents of each Obligor and of
resolutions of the board of directors (or similar governing body) of each Obligor approving and authorizing the execution, delivery and performance of this Agreement and each of the other Loan Documents to which it is a party, certified as of the
Closing Date by its secretary or assistant secretary as being in full force and effect without modification or amendment; (B) a good standing certificate and/or compliance certificate from the applicable Governmental Authority of each
Obligor’s jurisdiction of incorporation and in each jurisdiction in which it is qualified as a foreign corporation or other entity to do business, each dated a recent date prior to the Closing Date; and (C) such other documents as the
Lenders may have reasonably requested. 
 (vi) Incumbency Certificate. A certificate of each Obligor as to the
authority, incumbency and specimen signatures of the persons who have executed the Loan Documents and any other documents in connection herewith on behalf of the Obligors. 

  
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 (vii) Officer’s Certificate. A certificate, dated as of the
Closing Date and signed by a Responsible Officer of the Borrower, confirming compliance with the conditions set forth in this Section 6.01. 

(viii) Opinion of Counsel. A favorable opinion, dated as of the Closing Date, of Goodwin Procter LLP, counsel to each
Obligor in form reasonably acceptable to the Lenders and their counsel. 
 (ix) Evidence of Insurance. Certificates
from each Obligor’s insurance broker or other evidence satisfactory to the Lenders that all insurance required to be maintained pursuant to Section 8.05 is in full force and effect. 

(x) Sources and Uses Certificate. The Lenders shall have received the Sources and Uses Certificate duly executed and
delivered by a Responsible Officer of the Borrower, substantially in the form of Exhibit F hereto and otherwise in form and substance satisfactory to the Lenders. 

(f) Due Diligence. The Lenders shall have received and be satisfied with all due diligence regarding the Obligors
(including without limitation historical financial statements, technical, operational, legal, intellectual property, commercial market forecasts, clinical and regulatory assessments, supply chain, securities, labor, Tax, litigation, environmental,
reimbursement and regulatory authority matters) in their sole discretion. 
 (g) Indebtedness. As of the Closing Date,
after giving effect to the Transactions, no Obligor shall have any Indebtedness other than the Obligations and any Indebtedness specified on Schedule 7.13A. All amounts due or outstanding in respect of any Indebtedness other than the
Obligations and any Indebtedness specified on Schedule 7.13A shall have been repaid in full, all commitments (if any) in respect thereof terminated, all guarantees (if any) thereof discharged and released and all security therefor (if any)
released, together with all fees and other amounts owing thereon, or documentation in form and substance reasonably satisfactory to the Lenders to effect such release upon such repayment and termination shall have been delivered to the Lenders. 

(h) Closing Fees, Expenses, Etc. The Lenders and their Affiliates shall have received for their own account, the Closing
Fee and all reasonable and documented out-of-pocket fees, costs and expenses due (including reasonable and documented out-of-pocket attorney costs and the reasonable and documented out-of-pocket fees and expenses of any other advisors to the
Lenders) and payable pursuant to Section 13.03, after deducting therefrom the Expense Deposit. 
 (i) Warrants.
The Administrative Agent shall have received the executed Warrants, dated as of the Closing Date. 

  
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 (j) Representations and Warranties. The representations and warranties of the
Obligors contained in Article 7 or any other Loan Document shall be true and correct in all material respects on and as of the Closing Date; provided that to the extent that such representations and warranties specifically refer to an
earlier date, they shall be true and correct in all material respects as of such earlier date; provided further that any representation and warranty that is qualified as to “materiality”, “Material Adverse Effect” or
similar language shall be true and correct (after giving effect to any qualification therein) in all respects. 
 (k)
Required Equity Financing. Borrower shall have raised at least $60,000,000 of new cash equity in the form of Series B Preferred Stock, on terms reasonably satisfactory to the Administrative Agent. 

(l) No Default. No Default shall exist, or would result from such proposed borrowing of the Tranche A Term Loan or from
the application of the proceeds therefrom. 
 Section 6.02. Conditions to Tranche B Term Loan; Tranche B Term Loan
Borrowing Date. The obligation of each Lender to make the Tranche B Term Loan on the Tranche B Term Loan Borrowing Date shall not become effective until the following conditions precedent shall have been reasonably satisfied or waived in writing
by the Lenders (which satisfaction or waiver may be made simultaneously with the making of the Tranche B Term Loan hereunder): 

(a) Closing Conditions. All closing conditions as set forth in Section 6.01 shall have been satisfied or waived in
accordance with Section 13.04 on or before the Closing Date. 
 (b) Borrowing Notice. The Administrative Agent
shall have received a Borrowing Notice duly executed by a Responsible Officer of the Borrower. 
 (c) Representations and
Warranties. The representations and warranties of the Obligors contained in Article 7 or any other Loan Document shall be true and correct in all material respects on and as of the Tranche B Term Loan Borrowing Date; provided that to
the extent that such representations and warranties specifically refer to an earlier date, they shall be true and correct in all material respects as of such earlier date; provided further that any representation and warranty that is
qualified as to “materiality”, “Material Adverse Effect” or similar language shall be true and correct (after giving effect to any qualification therein) in all respects. 

(d) No Default. No Default shall exist, or would result from such proposed Borrowing or from the application of the
proceeds therefrom. 
 (e) Milestone. The Borrower shall have, on or prior to [***], filed an IND with respect to a
Specified Pipeline Target. 
 The borrowing of the Term Loans shall constitute a certification by the Borrower to the effect that the conditions set forth
in Section 6.01 and 6.02, as applicable, have been fulfilled as of the Closing Date or the Tranche B Term Loan Borrowing Date, as applicable. 

  
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 ARTICLE 7 

REPRESENTATIONS AND WARRANTIES 

In order to induce the Lenders to enter into this Agreement and to extend the Term Loans hereunder, each Obligor represents and warrants to
the Lenders and the Administrative Agent, on the Closing Date and on the Tranche B Term Loan Borrowing Date, that the following statements are true and correct: 

Section 7.01. Power and Authority. Each Obligor and each of its Subsidiaries (a) is duly organized,
validly existing and in good standing under the applicable laws of its jurisdiction of organization, (b) has all requisite corporate (or equivalent) power, and has all material governmental licenses, authorizations, consents and approvals
necessary to own its assets and carry on its business as now being or as proposed to be conducted except to the extent that failure to have the same would not reasonably be expected to have a Material Adverse Effect, (c) is qualified to do
business and is in good standing in all jurisdictions in which the nature of the business conducted by it makes such qualification necessary except where failure to so qualify would not (either individually or in the aggregate) reasonably be
expected to have a Material Adverse Effect, and (d) has full power, authority and legal right to make and perform each of the Loan Documents and, in the case of the Borrower, to borrow the Term Loans hereunder. 

Section 7.02. Authorization; Enforceability. The Transactions are within each Obligor’s corporate (or
equivalent) powers and have been duly authorized by all necessary corporate (or equivalent) action and, if required, by all necessary shareholder or other equity holder action. The Loan Documents have been duly executed and delivered by each Obligor
party thereto and constitutes, and each of the other Loan Documents to which it is a party when executed and delivered by such Obligor will constitute, a legal, valid and binding obligation of such Obligor, enforceable against each Obligor in
accordance with its terms, except as such enforceability may be limited by (a) bankruptcy, insolvency, reorganization, moratorium or similar Laws of general applicability affecting the enforcement of creditors’ rights and (b) the
application of general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law). 

Section 7.03. Governmental and Other Approvals; No Conflicts. The Transactions (a) do not require any
consent or approval of, registration or filing with, or any other action by, any Governmental Authority or any other Person, except for (i) such as have been obtained or made and are in full force and effect and (ii) filings and recordings
in respect of perfecting or recording the Liens created pursuant to the Security Documents, (b) will not violate any applicable Requirement of Law or the Organizational Documents of any Obligor or any applicable order of any Governmental
Authority, in each case, other than any such violations that, individually or in the aggregate, would not reasonably be expected to have a Material Adverse Effect, (c) will not violate or result in a default under any Material Agreement, or
give rise to a right thereunder to require any payment to be made by any such Person, and (d) will not result in the creation or imposition of any Lien (other than Permitted Liens) on any asset of any Obligor or any of its Subsidiaries. 

  
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 Section 7.04. Financial Statements; Material Adverse Change. 

(a) Financial Statements. The Borrower has heretofore furnished to the Administrative Agent certain financial statements as provided for
in Section 8.01. Such financial statements present fairly, in all material respects, the financial position and results of operations and cash flows of the Obligors as of such dates and for such periods substantially in accordance with GAAP,
subject to quarterly or year-end adjustments and the absence of footnotes. No Obligor has any material contingent liabilities or liabilities for taxes, long-term lease
or unusual forward or long-term commitments not disclosed in the aforementioned financial statements. 

(b) No Material Adverse Change. Since December 31, 2018 no event, circumstance or change has occurred that has caused or evidences,
either in individually or in the aggregate, a Material Adverse Change. 
 Section 7.05. Properties. 

(a) Property Generally. Each Obligor and each of its Subsidiaries has good and marketable fee simple title to, or valid leasehold
interests in, all its real and personal Property material to its business, subject only to Permitted Liens and except as would not reasonably be expected to interfere with its ability to conduct its business as currently conducted or to utilize such
properties for their intended purposes. 
 (b) Intellectual Property. (i) Schedule 7.05(b) lists, with respect to each
Obligor, all United States and foreign registrations of and applications for Patents, Trademarks, and Copyrights that are Obligor Intellectual Property, including the applicable jurisdiction, registration or application number and date, as
applicable thereto, a designation as to whether it is Material Intellectual Property, and a designation as to whether it is licensed or owned by an Obligor. 

(ii) Each Obligor (A) owns or possesses all legal and beneficial rights, title and interest in and to the Material Intellectual Property
designated on Schedule 7.05(b) as being owned by such Obligor and (B) has the right to use the Material Intellectual Property licensed to such Obligor, in each case with good and marketable title, free and clear of any Liens or Claims of
any kind other than Permitted Liens. 
 (iii) To each Obligor’s knowledge, the Material Intellectual Property does not violate any
license or infringe any valid and enforceable Intellectual Property right of another. 
 (iv) Other than with respect to the Material
Agreements, or as permitted by this Agreement, the Obligors have not assigned or otherwise transferred ownership of, or agreed to assign or otherwise transfer ownership of, any Material Intellectual Property, in whole or in part, to any Person who
is not an Obligor. 
 (v) Other than as set forth on Schedule 7.05(b), the Obligors have not received any written communications, nor is
there any pending or, to each Obligor’s knowledge, threatened action in writing, suit, proceeding or claim in writing by another, alleging that any of the Obligors has violated, infringed, diluted or misappropriated any Intellectual Property of
another. 

  
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 (vi) There is no pending or, to any Obligor’s knowledge, threatened action in writing,
suit, proceeding or claim in writing by another: (a) challenging an Obligor’s rights in or to any Material Intellectual Property owned by such Obligor; or (b) challenging the validity, enforceability or scope of any Material
Intellectual Property owned by an Obligor. 
 (vii) Each Obligor has taken commercially reasonable precautions to protect the secrecy,
confidentiality and value of the Material Intellectual Property. 
 (viii) Each Obligor has complied with the terms of each Material
Agreement pursuant to which Intellectual Property has been licensed to the Obligors (which material terms shall include, but not be limited to, pricing and duration of the agreement), unless such
non-compliance would not reasonably be expected to result in a Material Adverse Change. 
 (ix) All
maintenance fees, annuities, and the like due or payable on the Patents within the Material Intellectual Property owned by or exclusively licensed to an Obligor have been timely paid or the failure to so pay was the result of an intentional decision
by the applicable Obligor, which would not reasonably be expected to result in a Material Adverse Change. All documents and instruments necessary to register or apply for or renew registration of all Patents, Trademarks and Copyrights within the
Material Intellectual Property owned by an Obligor have been validly executed, delivered and filed in a timely manner with the United States Patent and Trademark Office or the United States Copyright Office, as applicable. 

(x) To each Obligor’s knowledge, (A) there are no material defects in any of the Patents within the Material Intellectual Property
and (B) no such Patents within the Material Intellectual Property have ever been finally adjudicated to be invalid, unpatentable or unenforceable for any reason in any administrative, arbitration, judicial or other proceeding. 

(xi) To each Obligor’s knowledge, no Obligor has received any written notice asserting that the Patents within the Material Intellectual
Property are invalid, unpatentable or unenforceable and, to each Obligor’s knowledge, no Obligor has engaged in any conduct, or omitted to perform any necessary act, the result of which would invalidate or render unpatentable or unenforceable
any such Patent within the Material Intellectual Property. 
 (xii) To the knowledge of each Obligor, no third party is infringing upon or
misappropriating, or violating any material license or agreement with such Obligor relating to any Material Intellectual Property. 
 (xiii)
The representations and warranties in this Section 7.05(b) are the exclusive representations and warranties with respect to Intellectual Property matters. 

Section 7.06. No Actions or Proceedings. 

(a) Litigation. There is no litigation, investigation or enforcement proceeding pending or threatened in writing with respect to any
Obligor by or before any Governmental Authority or arbitrator (i) that either individually or in the aggregate would reasonably be expected to have a Material Adverse Effect or (ii) that involves this Agreement or the Transactions. 

  
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 (b) Environmental Matters. The operations and the real Property of the Obligors
comply with all applicable Environmental Laws, except to the extent the failure to so comply, either individually or in the aggregate, would not reasonably be expected to have a Material Adverse Effect. To each Obligor’s knowledge, there have
been no conditions, occurrences or release of Hazardous Materials which would reasonably be expected to have a Material Adverse Effect. 

(c) Labor Matters. No Obligor has engaged in unfair labor practices and there are no pending or, to any Obligor’s knowledge,
threatened in writing labor actions, disputes, grievance or arbitration proceedings involving the employees of any Obligor, in each case that would reasonably be expected to have a Material Adverse Effect. There is no material strike or work
stoppage in existence or threatened in writing against any Obligor and to the knowledge of such Obligor, no union organization activity is taking place. 

Section 7.07. Compliance with Laws and Agreements. Each Obligor is in compliance with all Requirements of Law
(including Healthcare Laws and Environmental Laws) and all Contracts binding upon it or its Property, except where the failure to do so, individually or in the aggregate, would not reasonably be expected to result in a Material Adverse Effect. 

Section 7.08. Taxes. Each Obligor has timely filed or caused to be filed all federal income and other
material Tax returns and reports required to have been filed and has paid or caused to be paid all federal income and other material Taxes required to have been paid by it, except Taxes that are being contested in good faith by appropriate
proceedings and for which such Obligor has set aside on its books adequate reserves with respect thereto substantially in accordance with GAAP. 

Section 7.09. Full Disclosure. The Borrower has disclosed to the Lenders all Material Agreements to which any
Obligor is party, and all other matters to its knowledge, that, individually or in the aggregate, would reasonably be expected to result in a Material Adverse Effect. None of the reports, financial statements, certificates or other information
furnished by or on behalf of the Obligors to the Lenders in connection with the negotiation of this Agreement and the other Loan Documents or delivered hereunder or thereunder (as modified or supplemented by other information so furnished) contains
any material misstatement of material fact or omits to state any material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; provided that, with respect to projected
financial information, the Borrower represents only that such information was prepared in good faith based upon assumptions believed to be reasonable at the time (it being understood by the Administrative Agent and the Lenders that such projected
financial information is not to be viewed as facts, and that no assurances can be given that any particular projections will be realized and that actual results during the period or periods covered by any such projections may differ from the
projected results and such differences may be material). 
 Section 7.10. Regulation. 

(a) Investment Company Act. No Obligor is an “investment company” as defined in, or subject to regulation under, the
Investment Company Act of 1940. 

  
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 (b) Margin Stock. No Obligor is engaged principally, or as one of its important
activities, in the business of extending credit for the purpose, whether immediate, incidental or ultimate, of buying or carrying Margin Stock and no part of the proceeds of the Term Loans will be used to buy or carry any Margin Stock in violation
of Regulation T, U or X. 
 Section 7.11. Solvency. The Obligors, on a consolidated basis, are and,
immediately after giving effect to the Borrowings, the use of proceeds thereof, and the consummation of the Transactions, will be, Solvent. 

Section 7.12. Subsidiaries. Except for the Securities Subsidiary, the Borrower has no direct or indirect
Subsidiaries. 
 Section 7.13. Indebtedness and Liens. Set forth on Schedule 7.13A is a complete and
correct list of all Permitted Indebtedness described in Section 9.01(b) of each Obligor on the date hereof. Set forth on Schedule 7.13B is a complete and correct list of all Permitted Liens described in Section 9.02(b) granted by the
Borrower and other Obligors with respect to their respective Property and outstanding as of the date hereof. 

Section 7.14. Material Agreements. Set forth on Schedule 7.14 (as such Schedule may be updated by the
Borrower from time to time) is a complete and correct list of (i) each Material Agreement and (ii) each Contract creating or evidencing any Material Indebtedness, together with a summary reference to the Product or purpose of each such
Material Agreement and such Contract, to which an Obligor is a party. Accurate and complete copies of each such Contract listed on such schedule have been made available to the Lenders. No Obligor is in material default under any such Material
Agreement or such Contract creating or evidencing any Material Indebtedness listed on such schedule, and the Obligors have no knowledge of any material default by any counterparty to such Material Agreement or such Contract. Except as otherwise
disclosed on Schedule 7.14 (as such Schedule may be updated by the Borrower from time to time), all material vendor purchase agreements and provider Contracts of the Obligors, and all Material Agreements including a grant of rights under any
Intellectual Property to an Obligor, are in full force and effect without material modification from the form in which the same were disclosed to the Lenders. 

Section 7.15. Restrictive Agreements. None of the Obligors is party to any Restrictive Agreement, except
(i) those listed on Schedule 7.15 or otherwise permitted under Section 9.11, (ii) restrictions and conditions imposed by Law or by the Loan Documents, (iii) any stockholder agreement, charter, by laws or other organizational
documents of an Obligor and (iv) limitations associated with Permitted Liens. 
 Section 7.16. Real
Property. No Obligor or any of its Subsidiaries owns or leases (as tenant thereof) any real Property on the date hereof, except as described on Schedule 7.16. 

Section 7.17. Pension and Other Plans. Schedule 7.17 sets forth, as of the date hereof, a complete and correct
list of, and that separately identifies, (a) all Title IV Plans, (b) all Multiemployer Plans and (c) all material Benefit Plans. Each Benefit Plan, and each trust thereunder, intended to qualify for Tax exempt status under
Section 401 or 501 of the Code or 

  
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other Requirements of Law so qualifies. Except for those that would not, in the aggregate, have a Material Adverse Effect, (i) each Benefit Plan is in compliance with applicable provisions
of ERISA, the Code and other Requirements of Law, (ii) there are no existing or pending (or to the knowledge of any Obligor or Subsidiary thereof, threatened) claims (other than routine claims for benefits in the normal course), sanctions,
actions, lawsuits or other proceedings or investigation involving any Benefit Plan to which any Obligor or Subsidiary thereof incurs or otherwise has or would have an obligation or any liability or Claim and (iii) no ERISA Event is reasonably
expected to occur. The Borrower and each of its ERISA Affiliates has met all applicable requirements under the ERISA Funding Rules with respect to each Title IV Plan, and no waiver of the minimum funding standards under the ERISA Funding Rules
has been applied for or obtained. As of the most recent valuation date for any Title IV Plan, the funding target attainment percentage (as defined in Section 430(d)(2) of the Code) is at least 60%, and neither the Borrower nor any of its
ERISA Affiliates knows of any facts or circumstances that would reasonably be expected to cause the funding target attainment percentage to fall below 60% as of the most recent valuation date. As of the date hereof, no ERISA Event has occurred in
connection with which obligations and liabilities (contingent or otherwise) remain outstanding. No ERISA Affiliate would have any Withdrawal Liability as a result of a complete withdrawal from any Multiemployer Plan on the date this representation
is made. 
 Section 7.18. Collateral; Security Interest. Each Security Document is effective to create in
favor of the Administrative Agent for the benefit of the Lenders a legal, valid and enforceable security interest in the Collateral subject thereto and each such security interest is perfected to the extent required by (and has the priority required
by) the applicable Security Document, subject to Permitted Liens. The Security Documents collectively are effective to create in favor of the Administrative Agent for the benefit of the Lenders a legal, valid and enforceable security interest in the
Collateral, which upon the filing of financing statements and other similar statements filed in the appropriate offices, such security interests are perfected security interests to the extent that such perfection may be obtained by such filing,
subject only to Permitted Liens. 
 Section 7.19. Regulatory Approvals. (a) With respect to the Products,
each Obligor and each of its Subsidiaries holds either directly or through licensees and agents, all Regulatory Approvals and Permits necessary or required for each Obligor and its Subsidiaries to conduct all Product Development and
Commercialization Activities with respect to the Products. 
 (b) Set forth on Schedule 7.19(b) is a complete and accurate list as of
the date hereof of all Regulatory Approvals referred to in clause (a) above, setting forth (on a per Product basis) the Obligor that holds such Regulatory Approval and identifying the Product related to such Regulatory Approval. All such
Regulatory Approvals are (i) legally and beneficially owned exclusively by the Obligor identified on the Schedule, free and clear of all Liens other than Permitted Liens, (ii) validly registered and on file with the applicable Regulatory
Authority, in material compliance with all registration, filing and maintenance requirements (including any fee requirements) thereof, and (iii) in good standing, valid and enforceable with the applicable Regulatory Authority. All required and
material notices, registrations and listings, supplemental applications or notifications, reports (including annual reports, field alerts or other reports of adverse experiences) and all other required and material filings with respect to the
Products or any related Product Development and Commercialization Activities have been filed with the FDA and all other applicable Governmental Authorities. 

  
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 (c) (i) All material regulatory filings required by any Regulatory Authority or in
respect of any Regulatory Approval or Product Authorization with respect to any Product or any Product Development and Commercialization Activities have been made, and all such filings are complete and correct in all material respects and have
complied in all material respects with all applicable Requirements of Law, (ii) all clinical and pre-clinical trials, if any, of investigational Products have been and are being conducted by each Obligor
according to all applicable Requirements of Law in all material respects along with required monitoring of clinical investigator trial sites for their compliance, and (iii) each Obligor has disclosed to the Lenders all such material regulatory
filings and all material communications between representatives of each Obligor and any Regulatory Authority. 
 (d) Each Obligor and, to
each Obligor’s knowledge, each of its agents and Contract Manufacturers are in compliance in all material respects with all applicable statutes, rules and regulations (including all Regulatory Approvals and Product Authorizations) of all
applicable Governmental Authorities, including the FDA and all other Regulatory Authorities, with respect to each Product and all Product Development and Commercialization Activities related thereto. Each Obligor and, to each Obligor’s
knowledge, each Contract Manufacturer has and maintains in full force and effect all the necessary and requisite Regulatory Approvals and Product Authorizations. Each Obligor is in compliance in all material respects with all applicable registration
and listing requirements set forth in all applicable FDA Laws or equivalent regulation of each other Governmental Authority having jurisdiction over such Person. Each Obligor, and, to each Obligor’s knowledge, each Contract Manufacturer adheres
in all material respects to all applicable regulations of all Regulatory Authorities with respect to the Products and all Product Development and Commercialization Activities related thereto. 

(e) (i) No Obligor and, to each Obligor’s knowledge, no Contract Manufacturer has received from any Regulatory Authority any notice
of adverse findings with respect to any Product or any Product Development and Commercialization Activities related thereto, including any FDA Form 483 inspectional observations, notices of violations, Warning Letters, criminal proceeding
notices under Section 305 of the FD&C Act, or any other similar communication from any Regulatory Authority, (ii) there have been no seizures conducted or, to each Obligor’s knowledge, threatened by any Regulatory Authority with
respect to any Product, and no recalls, market withdrawals, field notifications, notifications of misbranding or adulteration or safety alerts conducted, requested or, to any Obligor’s knowledge, threatened by any Regulatory Authority with
respect to any Product, and no recalls, market withdrawals, field notifications, notifications of misbranding or adulteration or safety alerts have been conducted, requested or, to each Obligor’s knowledge, threatened by any Regulatory
Authority relating to any Products, and (iii) no Obligor and, to each Obligor’s knowledge, no Contract Manufacturer has received any written notification that remains unresolved from the FDA or any other Regulatory Authority indicating any
breach or violation of any applicable Product Authorization or Regulatory Approval, including that any of the Products is misbranded or adulterated as defined in the FD&C Act or the rules and regulations promulgated thereunder. 

  
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 (f) Neither any Obligor nor, to any Obligor’s knowledge, any officer, employee or agent
thereof or Contract Manufacturer, has made an untrue statement of a material fact or fraudulent statements to the FDA or any other Regulatory Authority, failed to disclose a material fact required to be disclosed to the FDA or any other Regulatory
Authority, or committed an act, made a statement, or failed to make a statement that, at the time such disclosure was made (or was not made), would reasonably be expected to provide a basis for the FDA or any other Regulatory Authority to invoke its
policy respecting Fraud, Untrue Statements of Material Facts, Bribery and Illegal Gratuities, set forth in 56 Fed. Reg. 46191 (September 10, 1991) or any similar policy. 

(g) No Obligor has received any written notice that the FDA or any other applicable Regulatory Authority has commenced or initiated, or, to the
knowledge of any such Obligor, threatened to commence or initiate, any action to withdraw any Regulatory Approval or Product Authorization or requested the recall of any Products or commenced or initiated or, to the knowledge of such Obligor,
threatened to commence or initiate, any action to enjoin any Product Development and Commercialization Activities of such Obligor or any Contract Manufacturer. 

(h) The clinical, preclinical, safety and other studies and tests conducted by or on behalf of or sponsored by each Obligor, or in respect of
which any Products or Product candidates under development have participated, were (and if still pending, are) being conducted materially in accordance with standard medical and scientific research procedures and all applicable Product
Authorizations. Each Obligor has operated within, and currently is in compliance in all material respects with, all applicable Laws, Product Authorizations and Regulatory Approvals, as well as the rules and regulations of the FDA and each other
Regulatory Authority. No Obligor has received any notices or other correspondence from the FDA or any other Regulatory Authority requiring the termination or suspension of any clinical, preclinical, safety or other studies or tests used to support
regulatory clearance of, or any Product Authorization or Regulatory Approval for, any Product. 
 (i) No material debarment or exclusionary
claims, actions, proceedings or investigations in respect of any Obligor’s business is pending, or to such Obligor’s knowledge, threatened in writing against such Obligor or its officers, employees or agents. No Obligor or, to such
Obligor’s knowledge, any officer, employee or agent of such Obligor, has been convicted of any crime or engaged in any conduct that would reasonably be expected to result in a debarment or exclusion under (i) Section 335a of the
FD&C Act or (ii) any similar applicable Law. 
 Section 7.20. Capitalization. All of the issued
and outstanding securities of each Obligor have been duly authorized, are validly issued, fully paid, and non-assessable. As of the Closing Date, except for the Warrants and except as set forth on
Schedule 7.20, there are no outstanding or authorized options, warrants, purchase rights, subscription rights, conversion rights, exchange rights, or other contracts or commitments that could require the Obligors to issue, sell, or otherwise
cause to become outstanding any of their ownership interests. There are no outstanding or authorized stock appreciation, phantom stock, profit participation, or similar rights with respect to the Obligors. There are no voting trusts, proxies, or
other agreements or understandings with respect to the voting of the ownership interests of the Obligors. None of the Equity Interests in the Obligors have been mortgaged, assigned or pledged in favor of any Person, other than pursuant to the
Security Agreement. 

  
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 Section 7.21. Insurance. Each Obligor has obtained (and is
maintaining), insurance for its assets (including the Collateral) and business as required under the Loan Documents. 

Section 7.22. Certain Fees. Except as described on Schedule 7.22, no broker’s or finder’s fee
will be payable in connection with the execution and delivery of this Agreement. 
 Section 7.23. Sanctions
Laws. Obligors and, to the knowledge of the Obligors, any director, officer or employee of an Obligor acting on behalf of the Obligors, are in compliance with the Sanctions Laws. 

Section 7.24. Anti-Corruption Laws. No Obligor nor any of its
Subsidiaries has, nor, to the knowledge of any Responsible Officer of any Obligor, has any director, officer, agent or employee of any Obligor acting on behalf of such Obligor (i) taken any action, directly or indirectly, that would result in a
violation by such Persons of the Anti-Corruption Laws, (ii) made, offered to make, promised to make or authorized the payment or giving of, directly or indirectly, any Prohibited Payment or
(iii) been subject to any investigation by any Governmental Authority with regard to any actual or alleged Prohibited Payment. 

Section 7.25. Anti-Terrorism Laws. The Obligors (i) have
taken reasonable measures to ensure compliance with applicable Economic Sanctions Laws and Anti-Terrorism Laws, (ii) are not Designated Persons and (iii) have not used any part of the proceeds from
any advance on behalf of any Designated Person or has not used, directly by it or indirectly through any Subsidiary, such proceeds in connection with any investment in, or any transactions or dealings with, any Designated Person. 

Section 7.26. Royalty and Other Payments. Except as set forth on Schedule 7.26, no Obligor, nor any of its
Subsidiaries, is obligated to pay any royalty, milestone payment, deferred payment or any other contingent payment in respect of any Product. 

ARTICLE 8 

AFFIRMATIVE COVENANTS AND FINANCIAL COVENANTS 

Each Obligor covenants and agrees with the Lenders that, until the Commitments have expired or been terminated and all Obligations (other than
the Warrant Obligations and inchoate indemnity obligations) have been paid in full in cash: 
 Section 8.01. Financial
Statements and Other Information. The Borrower will furnish to the Administrative Agent for distribution to the Lenders: 

(a) as soon as available and in any event within thirty (30) days after the end of each month, the consolidated balance
sheets of Borrower and its Subsidiaries as of the end of each such month, and the related consolidated statements of income and cash flows of Borrower and its Subsidiaries for such month, all in reasonable detail, together with a certificate of a
Responsible Officer of Borrower stating that such financial statements fairly present in all material respects the financial condition of Borrower and its Subsidiaries as at such date and the results of operations of Borrower and its Subsidiaries
for the period ended on such date and have been prepared substantially in accordance with GAAP consistently applied, subject to changes resulting from normal, quarterly or year-end adjustments and except for
the absence of notes; 

  
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 (b) commencing with the fiscal quarter ended June 30, 2020, as soon as
available and in any event within forty-five (45) days after the end of the first three quarters of each fiscal year and sixty (60) days, in the case of the fourth fiscal quarter of each fiscal year, the consolidated balance sheets of the
Borrower and its Subsidiaries as of the end of such quarter, and the related consolidated statements of income and cash flows of the Borrower and its Subsidiaries for such quarter and the portion of the fiscal year through the end of such quarter,
all in reasonable detail and setting forth in comparative form the figures for the corresponding period in the preceding fiscal year, together with a certificate of a Responsible Officer of the Borrower stating that such financial statements fairly
present in all material respects the financial condition of the Borrower and its Subsidiaries as at such date and the results of operations of the Borrower and its Subsidiaries for the period ended on such date and have been prepared substantially
in accordance with GAAP consistently applied, subject to changes resulting from normal quarterly or year-end adjustments and except for the absence of footnotes; provided that, if the Borrower is a
Publicly Reporting Company, the Borrower’s filing of a Quarterly Report on Form 10-Q with the SEC shall be deemed to satisfy the requirements of this Section 8.01(b) on the date on which such report
is first available via the SEC’s EDGAR system or a successor system related thereto; 
 (c) as soon as available and in
any event within one hundred eighty (180) days after the end of each fiscal year, the consolidated balance sheets of the Borrower and its Subsidiaries as of the end of such fiscal year, and the related consolidated statements of income,
shareholders’ equity and cash flows of the Borrower and its Subsidiaries for such fiscal year, prepared substantially in accordance with GAAP consistently applied, all in reasonable detail and setting forth in comparative form the figures for
the previous fiscal year, accompanied by (i) a report and opinion thereon of KPMG or another firm of independent certified public accountants of recognized national standing, which report and opinion shall be prepared in accordance with
generally accepted auditing standards and shall not be subject to any “going concern” or like qualification or exception or any qualification or exception as to the scope of such audit and (ii) a management’s discussion and
analysis of the financial condition and results of operations, including the Obligors’ liquidity and capital resources; provided that, if the Borrower is a Publicly Reporting Company, the Borrower’s filing of a Yearly Report on Form
10-K with the SEC shall be deemed to satisfy the requirements of this Section 8.01(c) on the date on which such report is first available via the SEC’s EDGAR system or a successor system related
thereto; 
 (d) within thirty (30) days after the end of each month, a compliance certificate of a Responsible Officer
of the Borrower as of the end of the applicable accounting period (which delivery may, unless a Lender requests executed originals, be by electronic communication including email and shall be deemed to be an original authentic counterpart thereof
for all purposes) in the form of Exhibit D (a “Compliance Certificate”) which, for 

  
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purposes of clarification, shall (i) demonstrate the Borrower’s compliance with Section 8.15 in respect of such month, (ii) state that the representations and warranties made
by the Obligors in Article 7 are true in all material respects on and as of the date thereof; provided that to the extent that such representations and warranties specifically refer to an earlier date, they shall be true and correct in
all material respects as of such earlier date; provided further that any representation and warranty that is qualified as to “materiality”, “Material Adverse Effect” or similar language shall be true and correct (after
giving effect to any qualification therein) in all respects, (iii) include details of any issues that are material that are raised by auditors and (iv) for each month end that coincides with the end of a fiscal year of the Borrower,
provide updated Schedules to this Agreement (if any); 
 (e) promptly, and in any event within five (5) Business Days
after receipt thereof by an Obligor thereof, copies of each notice or other correspondence received from any securities regulator or exchange to the authority of which an Obligor is subject concerning any investigation or possible investigation or
other inquiry by such agency regarding financial or other operational results of such Obligor; 
 (f) upon any renewal or
replacement, the information regarding insurance maintained by Obligors as required under Section 8.05; 
 (g) promptly
following the Lenders’ written request at any time, proof of the Borrower’s compliance with Section 8.15; 

(h) within ten (10) days of delivery, copies of all periodic reports distributed by the Borrower to its shareholders
generally; provided that (i) any such material may be redacted by the Borrower to exclude information relating to the Loan Documents or the Lenders and (ii) the Lenders shall not be entitled to receive statements, reports and
notices relating to topics that (A) are subject to attorney-client privilege or (B) present a conflict of interest for the Lenders; 

(i) a financial forecast for the Borrower and its Subsidiaries for each fiscal year, including forecasted balance sheets,
statements of income and cash flows of the Borrower and its Subsidiaries, all of which shall be prepared on a consolidated basis and delivered not later than February 28 of such fiscal year (the “Financial Forecast”); 

(j) promptly following any Lender’s written request, certification that such Obligor is not a passive foreign investment
company (“PFIC”) within the meaning of Sections 1291 through 1297 of the Code, or, if such Obligor determines that it is a PFIC, such information as would allow the Lender to make a qualified electing fund election with respect
to the stock of the Obligor; 
 (k) such other information respecting the operations, properties, business or condition
(financial or otherwise) of the Obligors (including with respect to the Collateral) as the Lenders may from time to time reasonably request; and 

  
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 (l) promptly after the receipt thereof, a copy of any “management
letter” received from its certified public accounts and the management’s response thereto. 
 Section 8.02.
Notices of Material Events. The Borrower will furnish to the Administrative Agent for distribution to the Lenders written notice of the following promptly after a Responsible Officer first learns of the existence of: 

(a) the occurrence of any Default or Event of Default; 

(b) the occurrence of any Casualty Event with respect to any Obligor’s Property resulting in a Loss, to the extent not
covered by insurance, aggregating $500,000 or more; 
 (c) (i) any proposed Acquisition by any Obligor that would
reasonably be expected to result in environmental liability under Environmental Laws in excess of $750,000, and (ii) in each case, to the extent that any of the following would reasonably be expected to result in liability in excess of
$750,000: (A) spillage, leakage, discharge, disposal, leaching, migration or release of any Hazardous Material required to be reported to any Governmental Authority under applicable Environmental Laws, and (B) all actions, suits, claims,
notices of violation, hearings, investigations or proceedings pending, or threatened in writing against or affecting any Obligor or any of its Subsidiaries or with respect to the ownership, use, maintenance and operation of their respective
businesses, operations or properties, relating to Environmental Laws or Hazardous Material; 
 (d) the assertion of any
environmental matter by any Person in writing against, or with respect to the activities of, any Obligor or any of its Subsidiaries and any alleged violation of or non-compliance with any Environmental Laws or
any permits, licenses or authorizations, in each case, which would reasonably be expected to involve damages in excess of $750,000 other than any environmental matter or alleged violation that, if adversely determined, would not (either individually
or in the aggregate) have a Material Adverse Effect; 
 (e) the filing or commencement of any action, suit or proceeding by
or before any arbitrator or Governmental Authority against or directly affecting any Obligor or any of its Subsidiaries, in each case, that would reasonably be expected to result in a Material Adverse Effect; 

(f) (i) on or prior to any filing by any ERISA Affiliate of any notice of intent to terminate any Title IV Plan, a
copy of such notice and (ii) promptly, and in any event within ten (10) days, after any Responsible Officer of any ERISA Affiliate knows or has reason to know that a request for a minimum funding waiver under Section 412 of the Code
has been filed with respect to any Title IV Plan or Multiemployer Plan, a notice (which may be made by telephone if promptly confirmed in writing) describing such waiver request and any action that any ERISA Affiliate proposes to take with
respect thereto, together with a copy of any notice filed with the PBGC or the IRS pertaining thereto; 

  
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 (g) within five (5) Business Days of obtaining written notice or
knowledge thereof: (i) the termination of any Material Agreement; (ii) the receipt by any Obligor or any of its Subsidiaries of a written notice under any Material Agreement (and a copy thereof) asserting a default by such Obligor or any
of its Subsidiaries where such alleged default would permit such counterparty to terminate such Material Agreement; (iii) the entering into any new Material Agreement by an Obligor (and a copy thereof); or (iv) any amendment to a Material
Agreement that would be materially adverse to the Lenders (and a copy thereof) (which includes, but is not limited to, any amendments to provisions relating to pricing and term); provided that notices required under this subsection
(g) may be delivered with monthly Compliance Certificate unless any of the foregoing events would reasonably be expected to have a Material Adverse Effect; 

(h) any product recalls, safety alerts, corrections, withdrawals, marketing suspensions, removals or the like conducted, to be
undertaken or issued by any Obligor or any of its Subsidiaries, whether or not at the request, demand or order of any Governmental Authority or otherwise with respect to any Product; 

(i) within ten (10) Business Days of obtaining written notice or knowledge thereof, any infringement or other violation by
any Person of any Obligor Intellectual Property that would reasonably be expected to result in a Material Adverse Effect; 

(j) within five (5) Business Days of obtaining written notice or knowledge thereof, a material licensing agreement or
arrangement entered into by any Obligor or any of its Subsidiaries in connection with any material infringement or alleged infringement of the Intellectual Property of another Person; 

(k) within ten (10) Business Days of obtaining written notice or knowledge thereof, any written claim by any Person that
the conduct of any Obligor’s (or any Subsidiary thereof) business, including the development, manufacture, use, sale or other commercialization of any Product, infringes any Intellectual Property of such Person, except to the extent any such
claim would not reasonably be expected to result in a Material Adverse Effect; 
 (l) the reports and notices as required by
the Security Documents; 
 (m) within thirty (30) days of the date thereof, or, if earlier, on the date of delivery of
any financial statements pursuant to Section 8.01, notice of any material change in accounting policies or financial reporting practices by the Obligors; 

(n) promptly after the occurrence thereof, notice of any labor controversy resulting in or threatening to result in any strike,
work stoppage, boycott, shutdown or other material labor disruption against or involving an Obligor (or any Subsidiary thereof); 

(o) any other development that results in a Material Adverse Effect; 

  
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 (p) concurrently with the delivery with Compliance Certificates pursuant to
Section 8.01(d), the creation or other acquisition of any Intellectual Property by any Obligor or any Subsidiary after the date hereof and during such prior fiscal year which is registered or becomes registered or the subject of an application
for registration with the United States Copyright Office or the United States Patent and Trademark Office, as applicable, or with any other equivalent foreign Governmental Authority; and 

(q) any change to any Obligor’s ownership of Deposit Accounts, Securities Accounts and Commodity Accounts, by delivering
to the Lenders an updated Schedule 7 to the Security Agreement setting forth a complete and correct list of all such accounts as of the date of such change. 

Each notice delivered under this Section 8.02 shall be accompanied by a statement of a Responsible Officer of the Borrower setting forth
in reasonable detail the event or development requiring such notice and any action taken or proposed to be taken with respect thereto; provided that, if the Borrower is a Publicly Reporting Company, the Borrower’s filing of notice of any
such event with the SEC shall be deemed to satisfy the requirements of this Section 8.02 on the date on which such report is first available via the SEC’s EDGAR system or a successor system related thereto. 

Notwithstanding any contrary provision of the Agreement or any other Loan Document (including, without limitation, Sections 8.01 and 8.02),
until such time as the Administrative Agent provides written notice to the Borrower that it no longer desires to receive information that constitutes material non-public information, the Borrower shall provide
any information required pursuant to the terms hereof, including any information that may be material non-public information, to the Administrative Agent; provided, that notwithstanding the forgoing,
the Borrower shall at all times comply with Section 8.01(d)(i)-(iv) and 8.02(a). 
 Section 8.03. Existence;
Maintenance of Properties, Etc. (a) It will, and will cause each of its Subsidiaries to, do or cause to be done all things necessary to preserve, renew and keep in full force and effect its legal existence; provided that the
foregoing shall not prohibit any merger, amalgamation, consolidation, liquidation or dissolution permitted under Section 9.03. 
 (b) It
shall, and shall cause each of its Subsidiaries to, maintain and preserve all rights, licenses, permits, privileges and franchises material to the conduct of its business, and maintain and preserve all of its assets and properties, necessary to the
conduct of its business in good working order and condition, ordinary wear and tear and damage from casualty or condemnation excepted. 
 (c)
It shall, and shall cause each of its Subsidiaries to, use commercially reasonable efforts to cause each new employee and contractor to execute and deliver a customary confidentiality, non-disclosure and
Intellectual Property assignment agreement that includes a waiver of moral rights. 

  
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 Section 8.04. Payment of Obligations. It will, and will
cause each of its Subsidiaries to, pay and discharge (i) all federal income and other material Taxes, fees, assessments and governmental charges or levies imposed upon it or upon its properties or assets prior to the date on which penalties
attach thereto, and all lawful claims for labor, materials and supplies which, if unpaid, might become a Lien (other than a Permitted Lien) upon any properties or assets of any Obligor, except to the extent such Taxes, fees, assessments or
governmental charges or levies, or such claims, are being contested in good faith by appropriate proceedings and are adequately reserved against substantially in accordance with GAAP, (ii) all lawful claims which, if unpaid, would by Law become
a Lien upon its Property not constituting a Permitted Lien and (iii) all other obligations if the failure to discharge such obligation would reasonably be expected to result in a Material Adverse Effect. 

Section 8.05. Insurance. At its own cost and expense, it will, and will cause each of its Subsidiaries, to
obtain and maintain, with financially sound and reputable insurers, insurance of the kinds, and in the amounts, as are consistent with customary practices and standards of its industry in the same or similar locations, it being understood and agreed
that the insurance held by the Obligors on the Closing Date is deemed to fulfill this requirement on the date hereof. All of the insurance policies required pursuant to this Section 8.05 will name the Administrative Agent as a “loss
payee,” “additional insured” or “mortgagee,” as applicable and as its interests may appear. The Borrower will use its commercially reasonable efforts to ensure, or to cause others to ensure, that all insurance policies
required pursuant to this Section 8.05 shall provide that they shall not be terminated or cancelled nor shall any policy be materially changed in a manner adverse to the insured Person without at least thirty (30) days’ written notice
to the Borrower and the Administrative Agent. Receipt of notice of termination or cancellation of any such insurance policies shall entitle the Administrative Agent to renew any such policies, all in accordance with the first sentence of this
Section 8.05 or otherwise to obtain similar insurance in place of such policies, in each case at the expense of the Borrower (payable within three (3) Business Days of any Borrower’s receipt of written demand therefor) and, unless an
Event of Default has occurred and is continuing, with the prior written consent of the Borrower (such consent not to be unreasonably withheld). The amount of any such expenses shall accrue interest at the Default Rate if not paid when due and shall
constitute “Obligations.” All of the insurance policies required hereby will be evidenced by one or more certificates of insurance, together with appropriate loss payee or additional insured clauses or endorsements in favor of the
Administrative Agent as required by this Section, delivered to the Administrative Agent on or before the Closing Date and at such other times as the Administrative Agent may request from time to time. 

Section 8.06. Books and Records; Inspection Rights. It will, and will cause each of its Subsidiaries to, keep
proper books of record and account in which full, true and correct entries are made of all dealings and transactions in relation to its business and activities. It will, and will cause each of its Subsidiaries to, permit any representatives
designated by the Administrative Agent, upon reasonable prior notice and at reasonable times, to visit and inspect its properties, to examine and make extracts from its books and records, and to discuss its affairs, finances and condition with its
officers and independent accountants, all at such reasonable times during normal business hours and with reasonable advance notice as the Administrative Agent may request. It will, and will cause each of its Subsidiaries to, pay all reasonable and
documented out-of-pocket expenses incurred by the Administrative Agent of (a) so long as no Default has occurred and is continuing, one (1) such inspection
each calendar year and (b) during a continuing Default, all such inspections. 

  
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 Section 8.07. Compliance with Laws. (a) It will, and
will cause each of its Subsidiaries to, (i) comply in all material respects with all Requirements of Law (including Healthcare Laws and Environmental Laws) and (ii) comply in all material respects with all terms of outstanding Indebtedness
and all Material Agreements, except where the failure to do so, individually or in the aggregate, would not reasonably be expected to result in a Material Adverse Effect. 

(b) Each Obligor will maintain, and will cause each of its Subsidiaries to maintain, all records required to be maintained by a Governmental
Authority or otherwise under any applicable Healthcare Law, except where failure to do so, individually or in the aggregate, would not reasonably be expected to have a Material Adverse Effect. 

Section 8.08. Licenses. It will, and will cause each of its Subsidiaries to, obtain and maintain all
licenses, authorizations, consents, filings, exemptions, registrations and other Governmental Approvals necessary in connection with the execution, delivery and performance of the Loan Documents, the consummation of the Transactions or the operation
and conduct of its business and ownership of its properties, except where failure to do so would not reasonably be expected to have a Material Adverse Effect. 

Section 8.09. Action under Environmental Laws. It will, and will cause each of its Subsidiaries to, upon a
Responsible Officer becoming aware of the release of any Hazardous Materials or the existence of any environmental liability under applicable Environmental Laws with respect to their respective businesses, operations or properties, take all actions,
at their cost and expense, as shall be required by applicable Law to investigate and clean up the condition of their respective businesses, operations or properties, including all required removal, containment and remedial actions, and restore their
respective businesses, operations or properties to a condition, in each case in material compliance with applicable Environmental Laws. 

Section 8.10. Use of Proceeds. The proceeds of the Term Loans will be used only as provided in
Section 2.05. No part of the proceeds of the Term Loans will be used, whether directly or indirectly, for any purpose that violates any of the Regulations of the Board of Governors of the Federal Reserve System, including Regulations T, U
and X. 
 Section 8.11. Certain Obligations Respecting Subsidiaries; Further Assurances; Intellectual Property.

 (a) Subsidiaries. It will take such action, and will cause each of its Subsidiaries (other than the Securities Subsidiary) to take
such action, from time to time as shall be necessary to ensure that all Subsidiaries (other than the Securities Subsidiary) are “Guarantors” hereunder. Without limiting the generality of the foregoing, in the event that the Borrower or any
of its Subsidiaries shall form or acquire any new Subsidiary, it and its Subsidiaries will promptly and in any event within thirty (30) days (or such longer time as consented to by the Administrative Agent in writing) of the formation or
Acquisition of such Subsidiary: 
 (i) cause such new Subsidiary to become a “Guarantor” hereunder, and a
“Grantor” under the Security Documents, pursuant to a Guarantee Assumption Agreement; 

  
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 (ii) take such action or cause such Subsidiary to take such action
(including delivering such Equity Interests, together with undated transfer powers executed in blank and any intercompany notes with undated endorsements executed in blank) as shall be necessary to create and perfect valid and enforceable first
priority (subject to Permitted Priority Liens) Liens on substantially all of the personal Property of such new Subsidiary as collateral security for the obligations of such new Subsidiary hereunder; 

(iii) to the extent that the parent of such Subsidiary is not a party to the Security Documents or has not otherwise pledged
Equity Interests in its Subsidiaries in accordance with the terms of the Security Documents and this Agreement, cause the parent of such Subsidiary to execute and deliver a pledge agreement in favor of the Lenders, in respect of all outstanding
issued shares of such Subsidiary; and 
 (iv) deliver such proof of corporate action, incumbency of officers, opinions of
counsel and other documents as is consistent with those delivered by each Obligor pursuant to Section 6.01 or as the Majority Lenders shall have requested. 

(b) Further Assurances. It will, and will cause each of its Subsidiaries to, take such action from time to time as shall reasonably be
requested in writing by the Majority Lenders to effectuate the purposes and objectives of this Agreement. Without limiting the generality of the foregoing, it will, and will cause each Person that is required to be a Guarantor to, take such action
from time to time (including executing and delivering such assignments, security agreements, control agreements and other instruments) as shall be reasonably requested in writing by the Majority Lenders to create, in favor of the Lenders, perfected
security interests and Liens (subject to Permitted Liens) in substantially all of the personal Property of such Obligor as collateral security for the Obligations; provided that any such security interest or Lien shall be subject to the
relevant requirements of the Security Documents. 
 (c) Intellectual Property. In the event that the Borrower or any of its
Subsidiaries creates, develops or acquires Obligor Intellectual Property during the term of this Agreement, then the provisions of this Agreement shall automatically apply thereto and any such Obligor Intellectual Property shall automatically
constitute part of the Collateral under the Security Documents, without further action by any party, in each case from and after the date of such creation, development or acquisition (except that any representations or warranties of any Obligor
shall apply to any such Obligor Intellectual Property only from and after the date, if any, subsequent to such acquisition that such representations and warranties are brought down or made anew as provided herein). In the event that the Borrower or
any of its Subsidiaries holds or acquires Obligor Intellectual Property during the term of this Agreement, then, upon the request of the Administrative Agent, the Borrower or any such Subsidiary shall take any action as shall be reasonably necessary
and reasonably requested by the Administrative Agent to ensure that the provisions of this Agreement and the Security Agreement shall apply thereto and any such Obligor Intellectual Property shall constitute part of the Collateral under the Security
Documents. 

  
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 Section 8.12. Termination of
Non-Permitted Liens. In the event that any Responsible Officer of the Borrower shall become aware or be notified by the Lenders of the existence of any outstanding Lien against any Property
of any Obligor, which Lien is not a Permitted Lien, such Obligor shall use its best efforts to promptly terminate or cause the termination of such Lien. 

Section 8.13. Non-Consolidation. The Borrower will, and will cause
each of its Subsidiaries to, (i) maintain entity records and books of account separate from those of any other entity (other than the Obligors) which is an Affiliate of such entity; and (ii) not commingle its funds or assets with those of
any other entity (other than the Obligors) which is an Affiliate of such entity. 
 Section 8.14. Anti-Terrorism and Anti-Corruption Laws. No Obligor shall engage in any transaction that violates any of the applicable prohibitions set forth in any Economic Sanctions
Law, Anti-Terrorism Law, or the US Foreign Corrupt Practices Act of 1977 (15 USC. §§ 78dd-1 et seq.). None of the funds
or assets of such Obligor or any Subsidiary that are used to repay the Term Loans shall constitute property of, or shall be beneficially owned by, any Designated Person or, to each Obligor’s knowledge, be the direct proceeds derived from any
transactions that violate the prohibitions set forth in any applicable Economic Sanctions Law, and no Designated Person shall have any direct or indirect interest in such Obligor insofar as such interest would violate any Economic Sanctions Laws
applicable to such Obligor. 
 Section 8.15. Minimum Liquidity. The Borrower shall ensure that the Borrower shall
have aggregate Unrestricted Cash of not less than $3,000,000 at all times (“Minimum Liquidity”). 

Section 8.16. Maintenance of Regulatory Approvals, Contracts, Intellectual Property, Etc. With respect to
each Product, such Obligor will, and will cause each of its Subsidiaries (to the extent applicable) to: (i) maintain in full force and effect all material Regulatory Approvals (including the Product Authorizations), Material Agreements, or
other rights necessary for the current operations of such Obligor’s or such Subsidiary’s business, as the case may be, including in respect of all related Product Development and Commercialization Activities, (ii) maintain in full
force and effect all material Intellectual Property owned or controlled by such Obligor or any such Subsidiary that is used in and necessary for related Product Development and Commercialization Activities and (iii) use commercially reasonable
efforts to pursue and maintain in full force and effect legal protection for all new, material Intellectual Property developed or controlled by such Obligor or any of its Subsidiaries, as the case may be, that is used in and necessary in connection
with any Product Development and Commercialization Activities relating to any such Product. 
 Section 8.17. Cash
Management. The Obligors will, and will cause each of their Subsidiaries to: 
 (a) maintain all Deposit Accounts,
Securities Accounts, Commodity Accounts and lockboxes (other than Excluded Accounts) with a bank or financial institution that has executed and delivered to the Administrative Agent an account control agreement, in form and substance reasonably
acceptable to the Administrative Agent (each such Deposit Account, Securities Account, Commodity Account and lockbox, a “Controlled Account”); and 

  
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 (b) deposit promptly, and in any event no later than five (5) Business
Days after the date of receipt thereof, all cash, checks, drafts or other similar items of payment relating to or constituting payments made in respect of any and all accounts and other rights and interests into Controlled Accounts. 

Section 8.18. Milestone. The Borrower shall: 

(a) (i) file an IND with respect to a Specified Pipeline Target on or prior to [***] and (ii) dose the first patient
in Phase I trial with respect to a Specified Pipeline Target on or prior to [***]; provided that the Borrower has the option to extend such date by up to an additional ninety (90) days by providing written notice of its intention to do
so to the Administrative Agent at least five (5) Business Days prior to [***]; provided, further that the Borrower may extend such additional period by another ninety (90) days subject to the Administrative Agent’s consent,
such consent not to be unreasonably withheld or delayed. 
 (b) on or before [***], either (i) complete a Qualified
Public Offering, (ii) issue at least $ [***] of new cash equity in the form of Series C Preferred Stock on terms reasonably satisfactory to the Administrative Agent or (iii) consummate an M&A Event; provided that the Borrower
has the option to extend such date by up to an additional ninety (90) days by providing written notice of its intention to do so to the Administrative Agent at least five (5) Business Days prior to [***]. 

Section 8.19. Certain Post-Closing Obligations. The Obligors will, and will cause each of their Subsidiaries to
provide the items set forth in Schedule 8.19 within the time periods set forth therein. 
 ARTICLE 9 

NEGATIVE COVENANTS 

Each Obligor covenants and agrees with the Lenders that, until the Commitments have expired or been terminated and all Obligations (other than
the Warrant Obligations and inchoate indemnity obligations) have been paid in full in cash: 
 Section 9.01.
Indebtedness. It will not, and will not permit any of its Subsidiaries to, create, incur, assume or permit to exist any Indebtedness, whether directly or indirectly, except: 

(a) the Obligations; 

(b) Indebtedness existing on the date hereof and set forth in Schedule 7.13A and Permitted Refinancings thereof; 

(c) accounts payable to trade creditors for goods and services and current operating liabilities (not the result of the
borrowing of money) incurred in the Ordinary Course of Business; 

  
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 (d) Indebtedness consisting of guarantees resulting from endorsement of
negotiable instruments for collection by it or any of its Subsidiaries in the Ordinary Course of Business; 
 (e)
Indebtedness of any Obligor to any other Obligor; 
 (f) Guarantees by any Obligor of the Indebtedness of any other Obligor;

 (g) Purchase money and capital lease financing; provided that (i) if secured, the collateral therefor consists
solely of the assets being financed, the products and proceeds thereof and books and records related thereto, (ii) in the case of purchase money Indebtedness, such Indebtedness shall constitute not less than 75% of the aggregate consideration
paid with respect to such asset and (iii) the aggregate outstanding principal amount of such Indebtedness does not exceed $750,000 at any time; 

(h) unsecured workers’ compensation claims, payment obligations in connection with health, disability or other types of
social security benefits, unemployment or other insurance obligations, reclamation and statutory obligations, in each case incurred in the Ordinary Course of Business; 

(i) Indebtedness under Hedging Agreements permitted pursuant to Section 9.05(f); 

(j) Indebtedness approved in advance in writing by the Majority Lenders; 

(k) Indebtedness of the Borrower and its Subsidiaries with respect to corporate credit cards not to exceed $500,000 at any time
outstanding; and 
 (l) other unsecured Indebtedness in an aggregate principal amount not to exceed $500,000 at any time
outstanding. 
 Section 9.02. Liens. It will not, and will not permit any of its Subsidiaries to, create, incur,
assume or permit to exist any Lien on any Property now owned by it, except: 
 (a) Liens securing the Obligations; 

(b) any Lien on any Property of any Obligor existing on the date hereof and set forth in Schedule 7.13B; provided
that (i) no such Lien shall extend to any other Property of such Obligor and (ii) any such Lien shall secure only those obligations which it secures on the date hereof and extensions, renewals and replacements thereof that do not increase
the outstanding principal amount thereof; 

  
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 (c) Liens securing Indebtedness permitted under Section 9.01(g);
provided that such Liens are restricted solely to the collateral described in Section 9.01(g); 
 (d) Liens
imposed by Law which were incurred in the Ordinary Course of Business, including (but not limited to) carriers’, warehousemen’s, landlords’ and mechanics’ liens, liens relating to leasehold improvements and other similar liens
arising in the Ordinary Course of Business and which (i) do not in the aggregate materially detract from the value of the Property subject thereto or materially impair the use thereof in the operations of the business of such Person or
(ii) are being contested in good faith by appropriate proceedings, which proceedings have the effect of preventing the forfeiture or sale of the Property subject to such liens and for which adequate reserves have been made if required
substantially in accordance with GAAP; 
 (e) Liens, pledges or deposits made in the Ordinary Course of Business in
connection with bids, contracts, leases, appeal bonds, workers’ compensation, unemployment insurance or other similar social security legislation; 

(f) Liens securing Taxes, assessments and other governmental charges, the payment of which is not yet due or is being contested
in good faith by appropriate proceedings promptly initiated and diligently conducted and for which such reserve or other appropriate provisions, if any, as shall be required by GAAP shall have been made; 

(g) servitudes, easements, rights of way, restrictions and other similar encumbrances on real Property imposed by applicable
Laws and encumbrances consisting of zoning or building restrictions, easements, licenses, restrictions on the use of Property or minor imperfections in title thereto which, in the aggregate, are not material, and which do not in any case materially
detract from the value of the Property subject thereto or interfere with the ordinary conduct of the business of any of the Obligors; 

(h) banker’s liens, rights of setoff and similar Liens incurred in the Ordinary Course of Business and arising in
connection with the Obligors’ deposit accounts or securities accounts held at financial institutions solely to secure payment of fees and similar costs and expenses of such financial institutions with respect to such accounts; 

(i) Liens in connection with transfers permitted under Section 9.09; 

(j) any judgment lien or lien arising from decrees or attachments not constituting an Event of Default; 

(k) leases or subleases of real property granted in the Ordinary Course of Business, and leases, subleases, nonexclusive
licenses or sublicenses of personal property (other than Intellectual Property) granted in the Ordinary Course of Business; 

(l) Liens in favor of customs and revenue authorities arising as a matter of law to secure the payment of custom duties in
connection with the importation of goods, not securing an amount in the aggregate in excess of $750,000 at any given time; 

(m) Liens on a deposit account of the Obligors and the cash and cash equivalents therein, in each case, securing Indebtedness
described in Section 9.01(k); and 

  
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 (n) Permitted Licenses solely to the extent that such Permitted License
would constitute a Lien; 
 provided that no Lien otherwise permitted under any of the foregoing Section 9.02 (excluding
Section 9.02(a)) shall apply to any Material Intellectual Property. 
 Section 9.03. Fundamental Changes and
Acquisitions. It will not, and will not permit any of its Subsidiaries to, (i) enter into or consummate any transaction of merger, amalgamation or consolidation, including without limitation, a
reverse-triangular merger, or other similar transaction or series of related transactions, (ii) liquidate, wind up or dissolve itself (or suffer any liquidation or dissolution) (including in connection
with any division or plan of division under Delaware law or any comparable event under a different jurisdiction’s laws), (iii) make or consummate any Acquisition, and (iv) make any public offering other than a Qualified Public
Offering, except: 
 (a) Investments permitted under Section 9.05(e); 

(b) Permitted Acquisitions for an aggregate consideration not to exceed $5,000,000 for the duration of this Agreement; and 

(c) the merger, amalgamation or consolidation of any Obligor with or into any other Obligor, provided that (i) if
the Borrower is a party to such merger, amalgamation or consolidation, the Borrower shall be the surviving entity and (ii) if a Domestic Subsidiary is a party to such merger, amalgamation or consolidation, a Domestic Subsidiary shall be the
surviving entity. 
 Section 9.04. Lines of Business. It will not, and will not permit any of its
Subsidiaries to, engage to any material extent in any business other than the business engaged in on the date hereof by such Obligor, or a business reasonably related, incidental or complementary thereto or reasonable extensions thereof. 

Section 9.05. Investments. It will not, and will not permit any of its Subsidiaries to, make, directly or
indirectly, or permit to remain outstanding any Investments except: 
 (a) Investments outstanding on the date hereof and
identified in Schedule 9.05 and any modification, replacement, renewal or extension thereof to the extent not involving new or additional Investments; 

(b) operating deposit accounts with banks; 

(c) extensions of credit in the nature of accounts receivable or notes receivable arising from the sales of goods or services
in the Ordinary Course of Business; 
 (d) Permitted Cash Equivalent Investments; 

  
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 (e) (i) Investments consisting of 100% of the ownership of the Equity
Interests of its Subsidiaries, (ii) Investments by the Borrower or any Subsidiary consisting of 100% of the ownership of the Equity Interests of the Person acquired in connection with a Permitted Acquisition and (iii) intercompany
Investments by the Borrower or its Subsidiaries in a Subsidiary that is a Guarantor or by any Subsidiary of Borrower in Borrower; 

(f) Hedging Agreements entered into in the ordinary course of any Obligor’s financial planning solely to hedge interest
rate risks (and not for speculative purposes) in respect of Permitted Indebtedness and in an aggregate amount for all such Hedging Agreements not in excess of $750,000; 

(g) Investments consisting of prepaid expenses, negotiable instruments held for collection or deposit, security deposits with
utilities, landlords and other like Persons, and deposits in connection with workers’ compensation and similar deposits, in each case made in the Ordinary Course of Business; 

(h) Investments received in connection with any Insolvency Proceedings in respect of any customers, suppliers or clients and in
settlement of delinquent obligations of, and other disputes with, customers, suppliers or clients; 
 (i) Investments
permitted pursuant to Section 9.03; 
 (j) Investments consisting of notes receivable of, or prepaid royalties and other
credit extensions, to customers and suppliers who are not Affiliates, in the Ordinary Course of Business; provided that this paragraph shall not apply to Investments of the Borrower in any Subsidiary; 

(k) Investments consisting of (i) travel advances and employee relocation loans and other employee loans and advances in
the Ordinary Course of Business, and (ii) loans to employees, officers or directors relating to the purchase of equity securities of the Borrower or its Subsidiaries pursuant to employee stock purchase plans or agreements approved by the
Borrower’s board of directors in an aggregate amount not to exceed $500,000 for subclauses (i) and (ii) in any fiscal year; 

(l) so long as no Event of Default has occurred and is continuing, Investments by any Obligor in another Obligor; 

(m) so long as no Default Event of Default shall have occurred and is continuing at the time of such Investment, Investments by
Borrower in the Securities Subsidiary, so long as the aggregate amount of cash and Permitted Cash Equivalent Investments held by Borrower is not less than (i) prior to the Tranche B Term Loan Borrowing Date, $12,500,000 and (ii) on and
after the Tranche B Term Loan Borrowing Date, $20,000,000; and 

  
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 (n) so long as no Default or Event of Default shall have occurred and is
continuing at the time of such Investment, or after giving effect thereto, other Investments in an amount not to exceed $500,000 in any fiscal year. 

Section 9.06. Restricted Payments. It will not, and will not permit any of its Subsidiaries to, declare or
make, or agree to pay or make, directly or indirectly, any Restricted Payment, other than: 
 (a) dividends with respect to
any Equity Interests of the Borrower or any of its Subsidiaries payable solely in additional shares of its Qualified Equity Interests; 

(b) any Restricted Payment by a Subsidiary to the Borrower; 

(c) any purchase, redemption, retirement, or other Acquisition by the Borrower or any of its Subsidiaries of shares of its
capital stock or other Equity Interests with the proceeds received from a substantially concurrent issue of new shares of its capital stock or other Equity Interests; 

(d) any non-cash (other than cash in lieu of fractional shares) conversion or exercise
requests in respect of any convertible securities, options or warrants of the Borrower into Qualified Equity Interests of the Borrower pursuant to the terms of such convertible securities, options or warrants or otherwise in exchange therefor; 

(e) repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements, stockholder
rights plans, director or consultant stock option plans, or similar plans in an aggregate amount not to exceed $250,000 in any fiscal year; 

(f) the making of cash payments in lieu of the issuance of fractional shares upon the conversion of convertible securities (or
in connection with the exercise of warrants or similar securities) not to exceed $25,000 in any fiscal year; 
 (g) cash
payments made to redeem, purchase, repurchase or retire the Warrant Obligations in accordance with the terms of the Warrants; and 

(h) dividends paid by any Guarantor to any other Obligor. 

Section 9.07. Payments of Indebtedness. It will not, and will not permit any of its Subsidiaries to, make any
payments in respect of any Material Indebtedness other than (i) payments of the Obligations, (ii) scheduled payments of other Permitted Indebtedness, and (iii) repayment of intercompany Indebtedness permitted in reliance upon
Section 9.01(e). 
 Section 9.08. Change in Fiscal Year. It will not, and will not permit any of its
Subsidiaries to, change the last day of its fiscal year from that in effect on the date hereof, without prior written notice to the Administrative Agent, except to change the fiscal year of a Subsidiary acquired in connection with an Acquisition to
conform its fiscal year to that of the Borrower. 

  
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 Section 9.09. Sales of Assets, Etc. It will not, and will
not permit any of its Subsidiaries to, sell, lease, exclusively license (in terms of geography or field of use), as a licensor, transfer (including in connection with any division or plan of division under Delaware law or any comparable event under
a different jurisdiction’s laws) or otherwise dispose of any of its Property (including accounts receivable and Equity Interests of Subsidiaries), or forgive, release or compromise any amount owed to the Borrower or any of its Subsidiaries, in
each case, in one transaction or series of transactions (any thereof, an “Asset Sale”), except: 

(a) transfers of cash or Permitted Cash Equivalent Investments in the Ordinary Course of Business for equivalent value; 

(b) sales or leases of inventory in the Ordinary Course of Business on ordinary business terms; 

(c) the forgiveness, release or compromise of any amount owed to the Borrower or any of its Subsidiaries in the Ordinary Course
of Business; 
 (d) entering into, or becoming bound, by a Permitted License to the extent not otherwise prohibited by this
Agreement; 
 (e) development and other collaborative arrangements where such arrangements provide for the license or
disclosure of Patents, Trademarks, Copyrights or other Intellectual Property rights of any Obligor in the Ordinary Course of Business and consistent with general market practices; provided that (i) such licenses must be true licenses
that do not result in a legal transfer of title of the licensed Property or otherwise constitute sales transactions in substance, and (ii) the aggregate amount of such periodic payments to the Obligors in any fiscal year shall not exceed
$500,000; 
 (f) a sale, lease, exclusive license, transfer or other disposition (including by way of abandonment or
cancellation) of any Property that is obsolete, worn out, surplus or no longer used or useful in connection with the business of the Obligors; 

(g) dispositions resulting from Casualty Events; 

(i) any transaction permitted under Section 9.02, 9.03, 9.05 and 9.20; 

(j) so long as no Default or Event of Default shall have occurred and is continuing at the time of such Asset Sale, or after
giving effect thereto, Asset Sales of other Property not to exceed $500,000 in the aggregate per fiscal year; and 
 (k)
transfers of Property between Obligors. 
 Section 9.10. Transactions with Affiliates. It will not, and will not
permit any of its Subsidiaries to, sell, lease, license or otherwise transfer any assets to, or purchase, lease, license or otherwise acquire any assets from, or otherwise engage in any other transactions with, any of its Affiliates, except: 

  
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 (a) transactions between or among the Obligors; 

(b) customary compensation and indemnification of, and other employment arrangements with, directors, officers and employees of
any Obligor in the Ordinary Course of Business; 
 (c) transactions upon fair and reasonable terms that are no less favorable
to any Obligor than would be obtained in a comparable arm’s-length transaction with a Person not an Affiliate; 

(d) the transactions set forth on Schedule 9.10; 

(e) any transaction permitted under Section 9.01, 9.05, 9.06 or 9.09; and 

(f) equity investments by Borrower’s investors in Borrower. 

Section 9.11. Restrictive Agreements. It will not, and will not permit any of its Subsidiaries to, directly
or indirectly, enter into, incur or permit to exist any Restrictive Agreement other than (i) restrictions and conditions imposed by Law or by the Loan Documents, (ii) Restrictive Agreements listed on Schedule 7.15, (iii) any stockholder
agreement, charter, by laws or other organizational documents of an Obligor as in effect on the date hereof or (iv) limitations associated with Permitted Liens or with any transaction permitted under Section 9.01, 9.03, 9.05, 9.06 or 9.09.

 Section 9.12. Organizational Documents, Material Agreements. (a) It will not, and will not permit any of
its Subsidiaries to, enter into any amendment to or modification of any Organizational Document without the prior written consent of the Administrative Agent, which consent shall not be unreasonably withheld, conditioned or delayed. 

(b) It will not, and will not permit any of its Subsidiaries to (i) enter into any material waiver, amendment or
modification of any Material Agreement (including, but not limited to, any amendments to provisions relating to pricing and term) that would be reasonably expected to adversely affect the Lenders in any material respect and (ii) take or omit to
take any action that results in the termination of, or permits any other Person to terminate, any Material Agreement or Material Intellectual Property that would be reasonably expected to adversely affect the Lenders in any material respect,
without, in each case, the prior written consent of the Administrative Agent, such consent not to be unreasonably withheld or delayed. 

Section 9.13. Operating Leases. It will not, and will not permit any of its Subsidiaries to, make any expenditures
in respect of operating leases, except for: 
 (a) real estate operating leases entered into in the Ordinary Course of
Business; 

  
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 (b) operating leases between Obligors; and 

(c) operating leases that would not cause the Borrower and its Subsidiaries, on a consolidated basis, to make payments
exceeding $750,000 in any fiscal year. 
 Section 9.14. Sales and Leasebacks. Except as permitted by
Section 9.01(g), it will not, and will not permit any of its Subsidiaries to, become liable, directly or indirectly, with respect to any lease, whether an operating lease or a Capital Lease Obligation, of any Property (whether real, personal,
or mixed), whether now owned or hereafter acquired, (i) which the Borrower or such Subsidiary has sold or transferred or is to sell or transfer to any other Person and (ii) which the Borrower or such Subsidiary intends to use for
substantially the same purposes as Property which has been or is to be sold or transferred. 
 Section 9.15. Hazardous
Material. It will not, and will not permit any of its Subsidiaries to, use, generate, manufacture, install, treat, release, store or dispose of any Hazardous Material, except in compliance with all applicable Environmental Laws or where
the failure to comply would not reasonably be expected to result in a Material Adverse Change. 
 Section 9.16.
Accounting Changes. It will not, and will not permit any of its Subsidiaries to, make any significant change in accounting treatment, except as required or permitted by GAAP. 

Section 9.17. Compliance with ERISA. No ERISA Affiliate shall cause or suffer to exist (a) any event
that would result in the imposition of a Lien with respect to any Title IV Plan or Multiemployer Plan or (b) any other ERISA Event that would, in the aggregate, have a Material Adverse Effect. No Obligor or any Subsidiary thereof shall
cause or suffer to exist any event that could result in the imposition of a Lien with respect to any Benefit Plan that would have a Material Adverse Effect. 

Section 9.18. Deposit Accounts. It will not, and will not permit any of its Subsidiaries to, establish or
maintain any bank account (other than an Excluded Account) that is not a Controlled Account and will not, and will not permit any of its Subsidiaries to, deposit proceeds in a bank account that is not a Controlled Account; provided, up to two
months of payroll expenses may be on deposit in Excluded Accounts in the aggregate at any time. 
 Section 9.19.
Outbound Licenses. It will not, and will not permit any of its Subsidiaries to, enter into or become bound by any outbound license or agreement unless such outbound license or agreement is a Permitted License. 

Section 9.20. Inbound Licenses. It will not, and will not permit any of its Subsidiaries to, enter into or
become bound by any inbound license or agreement (other than Permitted Licenses) unless (i) no Default has occurred and is continuing and (ii) such Obligor has taken such commercially reasonable actions as the Lenders may reasonably
request to obtain the consent of, or waiver by, any Person whose consent or waiver is necessary for the Lenders to be granted a valid and perfected security interest in such license or agreement allowing the Lenders to fully exercise their rights
under any of the Loan Documents in the event of a disposition or liquidation of the rights, assets or property that is the subject of such license or agreement; provided that the aggregate consideration paid for all such inbound licenses
pursuant to this Section 9.20 shall not exceed an amount equal to $5,000,000 per fiscal year. 

  
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 Section 9.21. Activities of Securities Subsidiary. Securities
Subsidiary shall not incur any Indebtedness or Liens, not make any Investments and shall not engage in any business activities and shall not own any property other than (a) activities permitted by, and Investments made in accordance with,
Massachusetts General Law, Chapter 63, Section 38B, (b) activities and contractual rights incidental to maintenance of its corporate existence, and (c) the performance of its obligations in its Organizational Documents. 

ARTICLE 10 

EVENTS OF DEFAULT 

Section 10.01. Events of Default. Each of the following events shall constitute an “Event of
Default”: 
 (a) the Borrower shall fail to pay any principal on the Term Loans when and as the same shall
become due and payable, whether at the due date thereof or at a date fixed for prepayment thereof or otherwise; or 
 (b) any
Obligor shall fail to pay any Obligation (other than an amount referred to in Section 10.01(a)) when and as the same shall become due and payable, and such failure shall continue unremedied for a period of three (3) Business Days; or 

(c) any representation or warranty made by or on behalf of an Obligor or any of its Subsidiaries in or in connection with this
Agreement or any other Loan Document or any amendment or modification hereof or thereof, or in any report, certificate, financial statement or other document furnished pursuant to or in connection with this Agreement or any other Loan Document or
any amendment or modification hereof or thereof, shall: (i) prove to have been incorrect when made or deemed made to the extent that such representation or warranty contains any materiality or Material Adverse Effect qualifier; or
(ii) prove to have been incorrect in any material respect when made or deemed made to the extent that such representation or warranty does not otherwise contain any materiality or Material Adverse Effect qualifier; or 

(d) any Obligor shall fail to observe or perform any covenant, condition or agreement contained in Section 8.01, 8.02,
8.03(a) (with respect to such Obligor’s existence), 8.10, 8.11, 8.13, 8.15, 8.16, 8.17, 8.18, 8.19 or Article 9; or 

(e) any Obligor shall fail to observe or perform any covenant, condition or agreement contained in this Agreement (other than
those specified in Section 10.01(a), (b) or (d)) or any other Loan Document, and, in the case of any failure that is capable of cure, such failure shall continue unremedied for a period of thirty (30) or more days; or 

  
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 (f) any Obligor shall fail to make any payment in respect of any Material Indebtedness, when
and as the same shall become due and payable after giving effect to any applicable grace or cure period as originally provided by the terms of such Indebtedness; or 

(g) (i) any material breach of, or “event of default” or similar event under, the Contract governing any Material Indebtedness
shall occur and such breach or “event of default” or similar event shall continue unremedied, uncured or unwaived after a period of ten (10) Business Days after the expiration of any cure period thereunder, or (ii) any event or
condition occurs (A) that results in any Material Indebtedness becoming due prior to its scheduled maturity or (B) that enables or permits (with or without the giving of notice, the lapse of time or both) the holder or holders of such
Material Indebtedness or any trustee or agent on its or their behalf to cause such Material Indebtedness to become due, or to require the prepayment, repurchase, redemption or defeasance thereof, prior to its scheduled maturity; provided that
this Section 10.01(g) shall not apply to secured Indebtedness that becomes due as a result of the voluntary sale or transfer of the Property securing such Material Indebtedness; or 

(h) any Obligor or any of its Subsidiaries: 

(i) ceases to be Solvent, or generally does not or becomes unable to pay its debts or meet its liabilities as the same become
due, or admits in writing its inability to pay its debts generally, or declares any general moratorium on its indebtedness, or proposes a compromise or arrangement or deed of company arrangement between it and any class of its creditors; or 

(ii) shall (A) voluntarily commence any proceeding or file any petition seeking liquidation, reorganization or other
relief under any Federal, state or foreign bankruptcy, insolvency, receivership or similar Law now or hereafter in effect, (B) consent to the institution of, or fail to contest in a timely and appropriate manner, any proceeding or petition
described in Section 10.01(i), (C) apply for or consent to the appointment of a receiver, trustee, custodian, sequestrator, conservator or similar official for an Obligor or any Subsidiary or for a substantial part of its assets,
(D) file an answer admitting the material allegations of a petition filed against it in any such proceeding, (E) make a general assignment for the benefit of creditors or (F) take any action for the purpose of effecting any of the
foregoing; or 
 (i) an involuntary proceeding shall be commenced or an involuntary petition shall be filed seeking (i) liquidation,
reorganization or other relief in respect of an Obligor or any Subsidiary or its debts, or of a substantial part of its assets, under any Federal, state or foreign bankruptcy, insolvency, receivership or similar law now or hereafter in effect or
(ii) the appointment of a receiver, trustee, custodian, sequestrator, conservator or similar official for an Obligor or any Subsidiary or for a substantial part of its assets, and, in any such case, such proceeding or petition shall continue
undismissed for sixty (60) days or an order or decree approving or ordering any of the foregoing shall be entered; or 

  
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 (j) one or more judgments for the payment of money in an aggregate amount in excess of
$750,000 (excluding any amounts covered by insurance as to which the applicable carrier has accepted coverage) shall be rendered against any Obligor or any combination thereof and the same shall remain undischarged for a period of forty-five
(45) consecutive days during which execution shall not be effectively stayed, or any action shall be legally taken by a judgment creditor to attach or levy upon any assets of any Obligor to enforce any such judgment; or 

(k) an ERISA Event shall have occurred that, in the opinion of the Lenders, when taken together with all other ERISA Events that have occurred,
would reasonably be expected to result in liability of the Obligors and their Subsidiaries in an aggregate amount exceeding (i) $250,000 in any year or (ii) $750,000 for all periods until repayment of all Obligations (other than the
Warrant Obligations); or 
 (l) a Change of Control shall have occurred; or 

(m) a Material Adverse Change shall have occurred; or 

(n) (i) any Lien created by any of the Security Documents shall at any time not constitute a valid and perfected Lien in favor of the
Administrative Agent on Collateral with an aggregate value in excess of $250,000, free and clear of all other Liens (other than Permitted Liens) except due to the action or inaction of the Administrative Agent or any Lender(s), (ii) except for
expiration in accordance with its terms and except due to the action or inaction of the Administrative Agent or any Lender(s), the Security Documents or any Guarantee of any of the Obligations shall for whatever reason cease to be in full force and
effect, or (iii) any of the Security Documents or any Guarantee of any of the Obligations, or the enforceability thereof, shall be repudiated or contested by any Obligor; or 

(o) any injunction, whether temporary or permanent, shall be rendered against any Obligor that prevents the Obligors from selling or
manufacturing the Product in the United States for more than one hundred twenty (120) consecutive calendar days; or 
 (p) (i) the
FDA or any other Governmental Authority (A) issues a letter or other communication asserting that any Product lacks a required Product Authorization, or (B) initiates enforcement action against, or issues a warning letter with respect to,
any Obligor, or any of their Products or the Contract Manufacturer therefor, that causes any Obligor or Subsidiary thereof to discontinue marketing or withdraw any of its material Products, or causes a delay in the manufacture of any of its material
Products, which discontinuance, withdrawal or delay would reasonably be expected to last for more than ninety (90) days, (ii) there is a recall of any Product that has generated or is expected to generate an aggregate amount of revenue
equal to at least $750,000 over any consecutive twelve (12) month period, or (iii) any Obligor or Subsidiary thereof enters into a settlement agreement with the FDA or any other Governmental Authority that results in aggregate
liability as to any single or related series of transactions, incidents or conditions, in excess of $750,000; or 

  
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 (q) any material Permit relating to any Product (including all Product
Authorizations), or any of the Obligors’ or their Subsidiaries’ material rights or interests thereunder, is terminated, adversely amended or otherwise determined to be ineffective in any manner adverse to any of the Products or Obligors or
Subsidiaries, in each case, for more than ninety (90) days; or 
 (r) a M&A Event shall have occurred. 

Section 10.02. Remedies. (a) Upon the occurrence of any Event of Default, then, and in every such event (other
than an Event of Default described in Section 10.01(h) or (i)), and at any time thereafter during the continuance of such event, the Majority Lenders may, by notice to the Borrower, take either or both of the following actions, at the same time
or different times: (i) terminate the Commitments, and thereupon the Commitments shall terminate immediately, and (ii) declare the Term Loans then outstanding to be due and payable in whole (or in part, in which case any principal not so
declared to be due and payable may thereafter be declared to be due and payable), and thereupon the principal of the Term Loans so declared to be due and payable, together with accrued interest thereon and all fees and other Obligations, shall
become due and payable immediately (in the case of the Term Loans, at the Redemption Price therefor), without presentment, demand, protest or other notice of any kind, all of which are hereby waived by each Obligor. 

(b) Upon the occurrence of any Event of Default described in Section 10.01(h) or (i), the Commitments shall automatically terminate and
the principal amount of the Term Loans then outstanding, together with accrued interest thereon and all fees and other Obligations, shall automatically become due and payable immediately (in the case of the Term Loans, at the Redemption Price
therefor), without presentment, demand, protest or other notice of any kind, all of which are hereby waived by each Obligor. 
 (c) If any
Lender collects any money or property pursuant to this Article 10, they shall pay out the money or property in the order set forth in Section 4.01(b). 

Section 10.03. Prepayment Fee and Redemption Price. For the avoidance of doubt, the Prepayment Fee (as a
component of the Redemption Price) shall be due and payable at any time the Term Loans become due and payable prior to the Stated Maturity Date for any reason (a “Premium Event”), whether due to acceleration pursuant
to the terms of this Agreement (in which case it shall be due immediately, upon the giving of notice to Borrower in accordance with Section 10.02(a), or automatically, in accordance with Section 10.02(b)), by operation of law or otherwise
(including, without limitation, on account of any bankruptcy filing). In view of the impracticability and extreme difficulty of ascertaining the actual amount of damages to the Lenders or profits lost by the Lenders as a result of such acceleration,
and by mutual agreement of the parties as to a reasonable estimation and calculation of the lost profits or damages of the Lenders, the Prepayment Fee shall be due and payable upon such date. Each Obligor hereby waives any defense to payment,
whether such defense may be based in public policy, ambiguity, or otherwise. The Obligors and the Lenders acknowledge and agree that any Prepayment Fee due and payable in accordance with this Agreement shall not constitute unmatured interest,
whether under Section 5.02(b)(3) of the Bankruptcy Code or otherwise. Each Obligor further acknowledges and agrees, and waives any argument to the contrary, that payment of such amount does not constitute a penalty or an otherwise unenforceable
or invalid obligation. 

  
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 ARTICLE 11 

GUARANTEE 

Section 11.01. The Guarantee. The Guarantors hereby jointly and severally guarantee to the Administrative
Agent and each Lender, and their respective successors and assigns, the prompt payment in full when due (whether at stated maturity, by acceleration or otherwise) of the principal of and interest on the Term Loans, all fees and other amounts and
Obligations from time to time owing to the Administrative Agent and the Lenders by the Borrower under this Agreement or under any other Loan Document and by any other Obligor under any of the Loan Documents, in each case strictly in accordance with
the terms thereof (such obligations being herein collectively called the “Guaranteed Obligations”). The Guarantors hereby further jointly and severally agree that if the Borrower shall fail to pay in full when due
(whether at stated maturity, by acceleration or otherwise) any of the Guaranteed Obligations, the Guarantors will promptly pay the same, without any demand or notice whatsoever, and that in the case of any extension of time of payment or renewal of
any of the Guaranteed Obligations, the same will be promptly paid in full when due (whether at extended maturity, by acceleration or otherwise) in accordance with the terms of such extension or renewal. 

Section 11.02. Obligations Unconditional. The obligations of the Guarantors under Section 11.01 are
absolute and unconditional, joint and several, irrespective of the value, genuineness, validity, regularity or enforceability of the obligations of the Borrower under this Agreement or any other agreement or instrument referred to herein, or any
substitution, release or exchange of any other guarantee of or security for any of the Guaranteed Obligations, and, to the fullest extent permitted by applicable Law, irrespective of any other circumstance whatsoever that might otherwise constitute
a legal or equitable discharge or defense of a surety or Guarantor, it being the intent of this Section 11.02 that the obligations of the Guarantors hereunder shall be absolute and unconditional, joint and several, under any and all
circumstances. Without limiting the generality of the foregoing, it is agreed that the occurrence of any one or more of the following shall not alter or impair the liability of the Guarantors hereunder, which shall remain absolute and unconditional
as described above: 
 (a) at any time or from time to time, without notice to the Guarantors, the time for any performance
of or compliance with any of the Guaranteed Obligations shall be extended, or such performance or compliance shall be waived; 

(b) any of the acts mentioned in any of the provisions of this Agreement or any other agreement or instrument referred to
herein shall be done or omitted; 
 (c) the maturity of any of the Guaranteed Obligations shall be accelerated, or any of the
Guaranteed Obligations shall be modified, supplemented or amended in any respect, or any right under this Agreement or any other agreement or instrument referred to herein shall be waived or any other guarantee of any of the Guaranteed Obligations
or any security therefor shall be released or exchanged in whole or in part or otherwise dealt with; or 

  
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 (d) any lien or security interest granted to, or in favor of, any Lender as
security for any of the Guaranteed Obligations shall fail to be perfected. 
 The Guarantors hereby expressly waive diligence, presentment,
demand of payment, protest and all notices whatsoever, and any requirement that the Administrative Agent or any Lender exhaust any right, power or remedy or proceed against the Borrower under this Agreement or any other agreement or instrument
referred to herein, or against any other Person under any other guarantee of, or security for, any of the Guaranteed Obligations. 

Section 11.03. Reinstatement. The obligations of the Guarantors under this Article 11 shall be
automatically reinstated if and to the extent that for any reason any payment by or on behalf of the Borrower in respect of the Guaranteed Obligations is rescinded or must be otherwise restored by any holder of any of the Guaranteed Obligations,
whether as a result of any proceedings in bankruptcy or reorganization or otherwise, and the Guarantors jointly and severally agree that they will indemnify the Administrative Agent and each Lender on demand for all reasonable costs and expenses
(including reasonable fees of counsel) incurred by such Persons in connection with such rescission or restoration, including any such reasonable costs and expenses incurred in defending against any claim alleging that such payment constituted a
preference, fraudulent transfer or similar payment under any bankruptcy, insolvency or similar Law. 
 Section 11.04.
Subrogation. The Guarantors hereby jointly and severally agree that, until the payment and satisfaction in full of all Guaranteed Obligations (other than the Warrant Obligations) they shall not exercise any right or remedy arising by
reason of any performance by them of their guarantee in Section 11.01, whether by subrogation or otherwise, against the Borrower or any other guarantor of any of the Guaranteed Obligations or any security for any of the Guaranteed Obligations.

 Section 11.05. Remedies. The Guarantors jointly and severally agree that, as between the Guarantors, on
one hand, and the Lenders, on the other hand, the obligations of the Borrower under this Agreement and under the other Loan Documents may be declared to be forthwith due and payable as provided in Article 10 (and shall be deemed to have become
automatically due and payable in the circumstances provided in Article 10) for purposes of Section 11.01 notwithstanding any stay, injunction or other prohibition preventing such declaration (or such obligations from becoming automatically
due and payable) as against the Borrower and that, in the event of such declaration (or such obligations being deemed to have become automatically due and payable), such obligations (whether or not due and payable by the Borrower) shall forthwith
become due and payable by the Guarantors for purposes of Section 11.01. 
 Section 11.06. Instrument for the
Payment of Money. Each Guarantor hereby acknowledges that the guarantee in this Article 11 constitutes an instrument for the payment of money, and consents and agrees that each Lender, at its sole option, in the event of a dispute by
such Guarantor in the payment of any moneys due hereunder, shall have the right to proceed by motion for summary judgment in lieu of complaint pursuant to N.Y. Civ. Prac. L&R § 3213. 

  
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 Section 11.07. Continuing Guarantee. The guarantee in this
Article 11 is a continuing guarantee, and shall apply to all Guaranteed Obligations (other than the Warrant Obligations) whenever arising. 

Section 11.08. Rights of Contribution. The Guarantors hereby agree, as between themselves, that if any
Guarantor shall become an Excess Funding Guarantor (as defined below) by reason of the payment by such Guarantor of any Guaranteed Obligations, each other Guarantor shall, on demand of such Excess Funding Guarantor (but subject to the next
sentence), pay to such Excess Funding Guarantor an amount equal to such Guarantor’s Pro Rata Share (as defined below and determined, for this purpose, without reference to the properties, debts and liabilities of such Excess Funding Guarantor)
of the Excess Payment (as defined below) in respect of such Guaranteed Obligations. The payment obligation of a Guarantor to any Excess Funding Guarantor under this Section 11.08 shall be subordinate and subject in right of payment to the prior
payment in full of the obligations of such Guarantor under the other provisions of this Article 11 and such Excess Funding Guarantor shall not exercise any right or remedy with respect to such excess until payment and satisfaction in full of
all of such obligations. 
 For purposes of this Section 11.08, (i) “Excess Funding Guarantor” means, in respect of
any Guaranteed Obligations, a Guarantor that has paid an amount in excess of its Pro Rata Share of such Guaranteed Obligations, (ii) “Excess Payment” means, in respect of any Guaranteed Obligations, the amount paid by an Excess
Funding Guarantor in excess of its Pro Rata Share of such Guaranteed Obligations and (iii) “Pro Rata Share” means, as of the date of determination, for any Guarantor, the ratio (expressed as a percentage) of (x) the amount by
which the aggregate present fair saleable value of all properties of such Guarantor (excluding any shares of stock of any other Guarantor) exceeds the amount of all the debts and liabilities of such Guarantor (including contingent, subordinated,
unmatured and unliquidated liabilities, but excluding the obligations of such Guarantor hereunder and any obligations of any other Guarantor that have been Guaranteed by such Guarantor) to (y) the amount by which the aggregate fair saleable
value of all properties of all of the Guarantors exceeds the amount of all the debts and liabilities (including contingent, subordinated, unmatured and unliquidated liabilities, but excluding the obligations of the Borrower and the Guarantors
hereunder and under the other Loan Documents) of all of the Guarantors, determined (A) with respect to any Guarantor that is a party hereto on the Closing Date, as of such date, and (B) with respect to any other Guarantor, as of the date
such Guarantor becomes a Guarantor hereunder. 
 Section 11.09. General Limitation on Guarantee
Obligations. In any action or proceeding involving any provincial, territorial or state corporate law, or any state or federal bankruptcy, insolvency, reorganization or other Law affecting the rights of creditors generally, if the
obligations of any Guarantor under Section 11.01 would otherwise, taking into account the provisions of Section 11.08, be held or determined to be void, invalid or unenforceable, or subordinated to the claims of any other creditors, on
account of the amount of its liability under Section 11.01, then, notwithstanding any other provision hereof to the contrary, the amount of such liability shall, without any further action by such Guarantor, the Administrative Agent, the
Lenders or any other Person, be automatically limited and reduced to the highest amount that is valid and enforceable and not subordinated to the claims of other creditors as determined in such action or proceeding. 

  
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 ARTICLE 12 

ADMINISTRATIVE AGENT 

Section 12.01. Appointment. Each of the Lenders hereby irrevocably appoints Perceptive Credit Holdings III, LP, a
Delaware limited partnership, to act on its behalf as the Administrative Agent hereunder and under the other Loan Documents and authorizes the Administrative Agent to take such actions on its behalf and to exercise such powers as are delegated to
the Administrative Agent by the terms hereof or thereof, together with such actions and powers as are reasonably incidental thereto. The provisions of this Article 12 are solely for the benefit of the Administrative Agent and the Lenders, and
neither the Borrower nor any other Obligor will have rights as a third-party beneficiary of any of such provisions. It is understood and agreed that the use of the term “agent” herein or in any other
Loan Documents (or any other similar term) with reference to the Administrative Agent is not intended to connote any fiduciary or other implied (or express) obligations arising under agency doctrine of any applicable Law. Instead, such term is used
as a matter of market custom, and is intended to create or reflect only an administrative relationship between contracting parties. 

Section 12.02. Rights as a Lender. The Person serving as the Administrative Agent hereunder will have the same
rights and powers in its capacity as a Lender as any other Lender and may exercise the same as though it were not the Administrative Agent, and the term “Lender” or “Lenders” will, unless otherwise expressly indicated or unless
the context otherwise requires, include the Person serving as the Administrative Agent hereunder in its individual capacity to the extent such Person is a Lender. The Lenders acknowledge and agree that such Person and its Affiliates may accept
deposits from, lend money to, own securities of, act as the financial advisor or in any other advisory capacity for, and generally engage in any kind of business with, the Borrower, the other Obligors or any other Subsidiaries or Affiliates of the
Obligors as if such Person were not the Administrative Agent hereunder and without any duty to account therefor to the Lenders. 

Section 12.03. Exculpatory Provisions. (a) The Administrative Agent will not have any duties or obligations
except those expressly set forth herein and in the other Loan Documents, and its duties hereunder are administrative in nature. Without limiting the generality of the foregoing, the Administrative Agent: 

(i) will not be subject to any fiduciary or other implied duties, regardless of whether a Default has occurred and is
continuing; 
 (ii) will not have any duty to take any discretionary action or exercise any discretionary powers, except
discretionary rights and powers expressly contemplated hereby or by the other Loan Documents that the Administrative Agent is required to exercise as directed in writing by the Majority Lenders (or such other number or percentage of the Lenders as
will be expressly provided for herein or in the other Loan Documents); provided that the Administrative Agent will not be required to take any action that, in its opinion or the opinion of its counsel, may expose the Administrative Agent to
liability or that is contrary to any Loan Document or applicable Law, including any action that may be in violation of the automatic stay under any Insolvency Proceeding; and 

  
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 (iii) will not, except as expressly set forth herein and in the other Loan
Documents, have any duty to disclose, and will not be liable for the failure to disclose, any information relating to the Obligors or any of its Subsidiaries or Affiliates that is communicated to or obtained by the Person serving as the
Administrative Agent or any of its Affiliates in any capacity. 
 (b) The Administrative Agent will not be liable for any action taken or not
taken by it (i) with the consent or at the request of the Majority Lenders (or such other number or percentage of the Lenders as will be necessary, or as the Administrative Agent believes in good faith will be necessary, under the
circumstances), or (ii) in the absence of its own gross negligence or willful misconduct as determined by a court of competent jurisdiction by final and non-appealable judgment. The Administrative Agent
will be deemed not to have knowledge of any Default unless and until notice describing such Default is given to the Administrative Agent in writing by the Borrower or a Lender. 

(c) The Administrative Agent will not be responsible for or have any duty to ascertain or inquire into (i) any statement, warranty or
representation made in or in connection with this Agreement or any other Loan Document, (ii) the contents of any certificate, report or other document delivered hereunder or thereunder or in connection herewith or therewith, (iii) the
performance or observance of any of the covenants, agreements or other terms or conditions set forth herein or therein or the occurrence of any Default, (iv) the validity, enforceability, effectiveness or genuineness of this Agreement, any
other Loan Document or any other agreement, instrument or document or (v) the satisfaction of any condition set forth in Article 6 or elsewhere herein, other than to confirm receipt of items expressly required to be delivered to the
Administrative Agent. 
 Section 12.04. Reliance by Administrative Agent. The Administrative Agent will be
entitled to rely upon, and will not incur any liability for relying upon, any notice, request, certificate, consent, statement, instrument, document or other writing (including any electronic message, Internet or intranet website posting or other
distribution) reasonably believed by it to be genuine and to have been signed, sent or otherwise authenticated by the proper Person. The Administrative Agent also may rely upon any statement made to it orally or by telephone and reasonably believed
by it to have been made by the proper Person, and will not incur any liability for relying thereon. In determining compliance with any condition hereunder to the making of the Term Loans that by its terms must be fulfilled to the satisfaction of a
Lender, the Administrative Agent may presume that such condition is satisfactory to such Lender unless the Administrative Agent has received notice to the contrary from such Lender prior to the making of such Term Loan. The Administrative Agent may
consult with legal counsel (who may be counsel for the Borrower), independent accountants and other experts selected by it, and will not be liable for any action taken or not taken by it in accordance with the advice of any such counsel, accountants
or experts. 

  
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 Section 12.05. Delegation of Duties. The Administrative Agent may
perform any and all of its duties and exercise its rights and powers hereunder or under any other Loan Document by or through any one or more sub-agents appointed by the Administrative Agent. The
Administrative Agent and any such sub-agent may perform any and all of its duties and exercise its rights and powers by or through their respective Affiliates. The exculpatory provisions of this Article
12 will apply to any such sub-agent and to the Affiliates of the Administrative Agent and any such sub-agent, and will apply to their respective activities in
connection with the syndication of the facility as well as activities as Administrative Agent. The Administrative Agent will not be responsible for the negligence or misconduct of any sub-agents except to the
extent that a court of competent jurisdiction determines in a final and non-appealable judgment that the Administrative Agent acted with gross negligence or willful misconduct in the selection of such sub-agents. 
 Section 12.06. Resignation of Agent. (a) The Administrative
Agent may at any time give notice of its resignation to the Lenders and the Borrower, which notice shall set forth the effective date of such resignation (the “Resignation Effective Date”), such date not to be earlier
than the thirtieth (30th) day following the date of such notice. The Majority Lenders and the Borrower shall mutually agree upon a successor to the Administrative Agent. If the Majority Lenders
and the Borrower are unable to so mutually agree and no successor shall have been appointed within twenty-five (25) days after the retiring Administrative Agent gives notice of its resignation, then the
retiring Administrative Agent may (but will not be obligated to), on behalf of the Lenders, appoint a successor Administrative Agent it shall designate (in its reasonable discretion after consultation with the Borrower and the Majority Lenders).
Whether or not a successor has been appointed, such resignation will become effective in accordance with such notice on the Resignation Effective Date. 

(b) With effect from the Resignation Effective Date (i) the retiring Administrative Agent will be discharged from its duties and
obligations hereunder and under the other Loan Documents (except that in the case of any Collateral held by the Administrative Agent on behalf of the Lenders under any of the Loan Documents, the retiring Administrative Agent will continue to hold
such Collateral until such time as a successor Administrative Agent is appointed) and (ii) except for any indemnity payments owed to the retiring Administrative Agent, all payments, communications and determinations provided to be made by, to
or through the Administrative Agent will instead be made by or to each Lender directly, until such time, if any, as the Majority Lenders appoint a successor Administrative Agent as provided for above. Upon the acceptance of a successor’s
appointment as Administrative Agent hereunder, such successor will succeed to and become vested with all of the rights, powers, privileges and duties of the retiring Administrative Agent (other than any rights to indemnity payments owed to the
retiring Administrative Agent), and the retiring Administrative Agent will be discharged from all of its duties and obligations hereunder or under the other Loan Documents. The fees payable by the Borrower to a successor Administrative Agent will be
the same as those payable to its predecessor unless otherwise agreed between the Borrower and such successor. After the retiring Administrative Agent’s resignation hereunder and under the other Loan Documents, the provisions of this
Article 12 and Sections 13.03 and 13.06 will continue in effect for the benefit of such retiring Administrative Agent, its sub-agents and their respective Affiliates in respect of any actions taken
or omitted to be taken by any of them while the retiring Administrative Agent was acting as Administrative Agent. 

  
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 Section 12.07.
Non-Reliance on Administrative Agent and Other Lenders. Each Lender acknowledges that it has, independently and without reliance upon the Administrative Agent or any other Lender or any of their
Affiliates and based on such documents and information as it has deemed appropriate, made its own credit analysis and decision to enter into this Agreement. Each Lender also acknowledges that it will, independently and without reliance upon the
Administrative Agent or any other Lender or any of their Affiliates and based on such documents and information as it will from time to time deem appropriate, continue to make its own decisions in taking or not taking action under or based upon this
Agreement, any other Loan Document or any related agreement or any document furnished hereunder or thereunder. 

Section 12.08. Administrative Agent May File Proofs of Claim. In case of the pendency of any Insolvency Proceeding
or any other judicial proceeding relative to the Borrower, the Administrative Agent (irrespective of whether the principal of the Term Loans will then be due and payable as herein expressed or by declaration or otherwise and irrespective of whether
the Administrative Agent has made any demand on the Borrower) will be entitled and empowered (but not obligated), by intervention in such proceeding or otherwise: 

(a) to file and prove a claim for the whole amount of the principal and interest owing and unpaid in respect of the Term Loans
and all other Obligations that are owing and unpaid hereunder or under any other Loan Document and to file such other documents as may be necessary or advisable in order to have the claims of the Lenders and the Administrative Agent (including any
claim for the reasonable compensation, expenses, disbursements and advances of the Lenders and the Administrative Agent and their respective agents and counsel and all other amounts due the Lenders and the Administrative Agent under this Agreement
or any other Loan Document) allowed in such judicial proceeding; and 
 (b) to collect and receive any monies or other
property payable or deliverable on any such claims and to distribute the same. 
 Any custodian, receiver, assignee, trustee, liquidator,
sequestrator or other similar official in any such judicial proceeding is hereby authorized by each Lender to make any payments of the type described above in this Section 12.08 to the Administrative Agent and, in the event that the
Administrative Agent consents to the making of such payments directly to the Lenders, to pay to the Administrative Agent any amount due for the reasonable compensation, expenses, disbursements and advances of the Administrative Agent and its agents
and counsel, and any other amounts due the Administrative Agent under this Agreement or any other Loan Document. 

Section 12.09. Collateral and Guaranty Matters; Appointment of Collateral Agent. (a) Without limiting the
provisions of Section 12.08, the Lenders irrevocably agree as follows: 
 (i) the Administrative Agent is authorized, at
its option and in its discretion, to release any Lien on any property granted to or held by the Administrative Agent under any Loan Document (A) on the date when all Obligations have been satisfied in full in cash (other than Warrant
Obligations and contingent obligations as to which no claims have been asserted), (B) that is sold or otherwise disposed of or to be sold or otherwise disposed of as part of or in connection with any sale or other disposition permitted under
the Loan Documents, or (C) subject to Sections 13.01 and 13.04, if approved, authorized or ratified in writing by the Majority Lenders; and 

  
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 (ii) the Administrative Agent is authorized, at its option and discretion,
to release any Subsidiary Guarantor from its obligations hereunder if such Person ceases to be a Subsidiary as a result of a transaction permitted under the Loan Documents. 

Upon request by the Administrative Agent at any time, each Lender will confirm in writing the Administrative Agent’s authority to release
or subordinate its interest in particular types or items of Collateral, or to release any Guarantor from its obligations under its guaranty pursuant to this Section 12.09. 

(b) The Administrative Agent will not be responsible for or have a duty to ascertain or inquire into any representation or warranty regarding
the existence, value or collectability of the Collateral, the existence, priority or perfection of the Administrative Agent’s Lien thereon, or any certificate prepared by any Obligor in connection therewith, nor will the Administrative Agent be
responsible or liable to the Lenders for any failure to monitor or maintain any portion of the Collateral. 
 (c) Each Lender hereby appoints
the Administrative Agent as its collateral agent under each of the Security Documents and agrees that, in so acting, the Administrative Agent will have all of the rights, protections, exculpations, indemnities and other benefits provided to the
Administrative Agent under this Agreement, and hereby authorizes and directs the Administrative Agent, on behalf of such Lender and all Lenders, without the necessity of any notice to or further consent from any of the Lenders, from time to time to
(i) take any action with respect to any Collateral or any Security Document which may be necessary to perfect and maintain perfected the Liens on the Collateral granted pursuant to any such Security Document or protect and preserve the
Administrative Agent’s ability to enforce the Liens or realize upon the Collateral, (ii) act as collateral agent for each Lender for purposes of acquiring, holding, enforcing and perfecting all Liens created by the Loan Documents and all
other purposes stated therein, (iii) enter into intercreditor or subordination agreements, as the case may be, in connection with Indebtedness permitted pursuant to Section 9.01(e), (iv) enter into
non-disturbance or similar agreements in connection with licensing agreements and arrangements permitted by this Agreement and the other Loan Documents and (v) otherwise to take or refrain from taking any
and all action that the Administrative Agent shall deem necessary or advisable in fulfilling its role as collateral agent under any of the Security Documents. 

ARTICLE 13 

MISCELLANEOUS 

Section 13.01. No Waiver. No failure on the part of the Administrative Agent or the Lenders to exercise and
no delay in exercising, and no course of dealing with respect to, any right, power or privilege under any Loan Document shall operate as a waiver thereof, nor shall any single or partial exercise of any right, power or privilege under any Loan
Document preclude any other or further exercise thereof or the exercise of any other right, power or privilege. The remedies provided herein are cumulative and not exclusive of any remedies provided by Law. 

  
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 Section 13.02. Notices. All notices, requests,
instructions, directions and other communications provided for herein (including any modifications of, or waivers, requests or consents under, the Loan Documents) shall be given or made in writing (including by telecopy or electronic mail)
delivered, if to the Borrower, another Obligor, the Administrative Agent or the Lenders, to its address specified on the signature pages hereto or its Guarantee Assumption Agreement, as the case may be, or at such other address as shall be
designated by such party in a notice to the other parties. Except as otherwise provided in this Agreement, all such communications shall be deemed to have been duly given upon receipt of a legible copy thereof, in each case given or addressed as
aforesaid. All such communications provided for herein by telecopy or electronic mail shall be confirmed in writing promptly after the delivery of such communication (it being understood that non-receipt of
written confirmation of such communication shall not invalidate such communication). 
 Section 13.03. Expenses,
Indemnification, Etc. 
 (a) Expenses. Each Obligor agrees to pay or reimburse (i) the Administrative Agent and the Lenders
for all of their reasonable and documented out of pocket costs and expenses (including the reasonable documented out of pocket fees and expenses of Chapman and Cutler LLP, counsel to the Administrative Agent) in connection with (x) the
negotiation, preparation, execution and delivery of this Agreement and the other Loan Documents and the making of the Tranche A Term Loan (exclusive of post-closing costs)
(y) post-closing costs and (z) the negotiation or preparation of any amendment, modification, supplement or waiver of any of the terms of this Agreement or any of the other Loan Documents (whether or
not consummated) and (ii) the Administrative Agent and the Lenders for all of their reasonable and documented out of pocket costs and expenses (including the reasonable and documented out of pocket fees and expenses of legal counsel) in
connection with any enforcement or collection proceedings resulting from the occurrence of an Event of Default. 
 (b) Indemnification.
Each Obligor hereby indemnifies the Administrative Agent, the Lenders, their respective Affiliates, and their respective directors, officers, employees, attorneys, agents and advisors (each, an “Indemnified Party”) from and
against, and agrees to hold them harmless against, any and all Claims and Losses of any kind (including reasonable fees and disbursements of counsel), joint or several, that is incurred by or asserted or awarded against any Indemnified Party, in
each case arising out of or in connection with or relating to any investigation, litigation or proceeding or the preparation of any defense with respect thereto arising out of or in connection with or relating to this Agreement or any of the other
Loan Documents or the Transactions or any use made or proposed to be made with the proceeds of the Term Loans, whether or not such investigation, litigation or proceeding is brought by an Obligor, any of its shareholders or creditors, an Indemnified
Party or any other Person, or an Indemnified Party is otherwise a party thereto, and whether or not any of the conditions precedent set forth in Article 6 are satisfied or the other transactions contemplated by this Agreement are consummated,
except to the extent such Claim or Loss is found in a final, non-appealable judgment by a court of competent jurisdiction to have resulted from any Indemnified Party’s gross negligence or willful

  
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misconduct. No Obligor shall assert any claim against any Indemnified Party, on any theory of liability, for consequential, indirect, special or punitive damages arising out of or otherwise
relating to this Agreement or any of the other Loan Documents or any of the Transactions or the actual or proposed use of the proceeds of the Term Loans. No Lender shall assert any claim against any Obligor, any Obligor’s Subsidiaries, or the
directors, officers, employees, attorneys, agents and advisers of any Obligor or Obligor’s Subsidiary, on any theory of liability, for consequential, indirect, special or punitive damages arising out of or otherwise relating to this Agreement
or any of the other Loan Documents or any of the transactions contemplated hereby or thereby or the actual or proposed use of the proceeds of the Term Loans. This Section shall not apply to Taxes other than Taxes relating to a non-Tax Claim or Loss governed by this Section 13.03(b). 
 Section 13.04.
Amendments, Etc. Except as otherwise expressly provided in this Agreement, any provision of this Agreement or any other Loan Document (except for the Warrant, which may be amended, modified, waived or supplemented in accordance with the terms
thereof) may be amended, modified, waived or supplemented only by an instrument in writing signed by the Borrower, the Administrative Agent and the Majority Lenders; provided that: 

(a) no amendment, waiver or consent shall, unless in writing and signed by all of the Lenders, do any of the following at any
time: 
 (i) change the number of Lenders or the percentage of (x) the Commitments or (y) the aggregate unpaid
principal amount of the Term Loans that, in each case, shall be required for the Lenders or any of them to take any action hereunder (including pursuant to any change to the definition of “Majority Lenders”); 

(ii) release one or more Guarantors (or otherwise limit such Guarantors’ liability with respect to the Obligations owing
to the Lenders under the Guarantees) if such release or limitation is in respect of all or substantially all of the value represented by the Guarantees to the Lenders; 

(iii) release, or subordinate the Lenders’ Liens in, all or substantially all of the Collateral in any transaction or
series of related transactions (other than in connection with any sale of Collateral permitted herein); or 
 (iv) amend any
provision of this Section 13.04; 
 (b) no amendment, waiver or consent shall, unless in writing and signed by each
Lender specified below for such amendment, waiver or consent: 
 (i) increase the Commitments of a Lender without the consent
of such Lender; 
 (ii) reduce the principal of, or stated rate of interest on, or Prepayment Fee payable on, the Term Loans
owed to a Lender or any fees or other amounts stated to be payable hereunder or under the other Loan Documents to such Lender without the consent of such Lender; 

  
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 (iii) postpone any date scheduled for any payment of principal of, or
interest on, the Term Loans, any date scheduled for payment or for any date fixed for any payment of fees hereunder (excluding the due date of any mandatory prepayment of a Term Loan), in each case payable to a Lender without the consent of such
Lender; 
 (iv) change the order of application of prepayment of the Term Loans from the application thereof set forth in the
applicable provisions of Section 4.01(b) or Section 4.01(c) in any manner that adversely affects the Lenders without the consent of holders of a majority of the Commitments or Term Loans outstanding or otherwise change any provision
requiring the pro rata distributions hereunder among the Lenders without all Lenders’ consent; or 
 (v) modify
Section 2.02 without the consent of each Lender directly and adversely affected thereby. 
 Section 13.05.
Successors and Assigns. 
 (a) General. The provisions of this Agreement shall be binding upon and inure to the benefit of the
parties hereto and their respective successors and assigns permitted hereby, except that (i) no Obligor may assign or otherwise transfer any of its rights or obligations hereunder without the prior written consent of the Administrative Agent
and each Lender (and any attempted assignment or transfer by such Obligor without such consent shall be null and void) and (ii) no Lender may assign or otherwise transfer its rights or obligations hereunder except in accordance with this
Section. Nothing in this Agreement, expressed or implied, shall be construed to confer upon any Person (other than the parties hereto, their respective successors and assigns permitted hereby, Participants (to the extent provided in
paragraph (e) of this Section) and, to the extent expressly contemplated hereby, the Indemnified Parties of the Lenders) any legal or equitable right, remedy or claim under or by reason of this Agreement. 

(b) Amendments to Loan Documents; Majority Lender Vote. Each of the Lenders and the Obligors agrees to enter into such amendments to the
Loan Documents, and such additional Security Documents and other instruments and agreements, in each case in form and substance reasonably acceptable to the Lenders and the Obligors, as shall reasonably be necessary to implement and give effect to
any assignment made by any Lender (or any direct or indirect assignee thereof) from time to time under this Section 13.05. 
 (c)
Assignments by Lenders. (i) Subject to the conditions set forth in paragraph (c)(ii) below, any Lender may assign to one or more Persons (other than an Ineligible Assignee) all or a portion of its rights and obligations under the
Loan Documents (including all or a portion of its Commitment and the Term Loans at the time owing to it) with the prior written consent (such consent not to be unreasonably withheld) of the Administrative Agent, provided that no consent of the
Administrative Agent shall be required for an assignment of any Commitment or of all or any portion of a Term Loan to a Lender, an Affiliate of a Lender or an Approved Fund. 

  
 -85- 

 (ii) Assignments shall be subject to the following additional conditions:

 (A) except in the case of an assignment to a Lender or an Affiliate of a Lender or an assignment of the entire remaining
amount of the assigning Lender’s Commitment or Term Loans, the amount of the Commitment or Term Loans of the assigning Lender subject to each such assignment (determined as of the date the Assignment Agreement with respect to such assignment is
delivered to the Administrative Agent) shall not be less than $1,000,000, unless the Administrative Agent otherwise consents; 

(B) each partial assignment shall be made as an assignment of a proportionate part of all the assigning Lender’s rights
and obligations under this Agreement and the other Loan Documents; and 
 (C) the parties to each assignment shall execute
and deliver to the Administrative Agent an Assignment Agreement in form and substance reasonably satisfactory to Administrative Agent. 

For the purposes of this Section 13.05(c), the term “Approved Fund” and “Ineligible Assignee” have the
following meanings: 
 “Approved Fund” means any Person (other than a natural person) that is engaged in
making, purchasing, holding or investing in bank loans and similar extensions of credit in the ordinary course of its business and that is administered or managed by (a) a Lender, (b) an Affiliate of a Lender or (c) an entity or an
Affiliate of an entity that administers or manages a Lender. 
 “Ineligible Assignee” means (a) a
natural person, (b) the Obligors or any of their respective Affiliates or (c) so long as no Event of Default has occurred and is continuing, a Competitor of any Obligor. 

(iii) Subject to acceptance and recording thereof pursuant to paragraph (d) of this Section, from and after the effective
date specified in each Assignment Agreement, the assignee thereunder shall be a party hereto and, to the extent of the interest assigned by such Assignment Agreement, have the rights and obligations of a Lender under the Loan Documents, and the
assigning Lender thereunder shall, to the extent of the interest assigned by such Assignment Agreement, be released from its obligations under the Loan Documents (and, in the case of an Assignment Agreement covering all of the assigning
Lender’s rights and obligations under the Loan Documents, such Lender shall cease to be a party hereto). Any assignment or transfer by a Lender of rights or obligations under the Loan Documents that does not comply with this Section 13.05
shall be treated for purposes of the Loan Documents as a sale by such Lender of a participation in such rights and obligations in accordance with paragraph (e) of this Section. 

  
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 (d) Register. The Administrative Agent, acting for this purpose as a non-fiduciary agent of the Borrower, shall maintain at one of its offices a copy of each Assignment Agreement delivered to it and a register for the recordation of the names and addresses of the Lenders, and the
Commitment of, and principal amount (and stated interest) of the Term Loans owing to, each Lender pursuant to the terms hereof from time to time (the “Register”). The entries in the Register shall be conclusive absent manifest
error, and the Borrower, the Administrative Agent, and the Lenders shall treat each Person whose name is recorded in the Register pursuant to the terms hereof as a Lender hereunder for all purposes of this Agreement, notwithstanding notice to the
contrary. The Register shall be available for inspection by the Borrower and any Lender, at any reasonable time and from time to time upon reasonable prior notice. No assignment shall be effective for purposes of this Agreement unless (i) it
has been recorded in the Register as provided in this paragraph and (ii) any written consent to such assignment required by paragraph (b) of this Section has been obtained. 

(e) Participations. Any Lender may at any time, without the consent of, or notice to, the Borrower, sell participations to any Person
(a “Participant”), other than a natural person, in all or a portion of such Lender’s rights and obligations under the Loan Documents (including all or a portion of its Commitment and the Term Loans owing to it); provided
that (i) such Lender’s obligations under the Loan Documents shall remain unchanged, (ii) such Lender shall remain solely responsible to the other parties hereto for the performance of such obligations and (iii) the Borrower shall
continue to deal solely and directly with such Lender in connection therewith. 
 (f) Any agreement or instrument pursuant to which a Lender
sells such a participation shall provide that such Lender shall retain the sole right to enforce this Agreement and to approve any amendment, modification or waiver of any provision of this Agreement; provided that such agreement or
instrument may provide that such Lender will not, without the consent of the Participant, agree to any amendment, modification or waiver that would (i) increase or extend the term of such Lender’s Commitment, (ii) extend the date
fixed for the payment of principal of or interest on the Term Loans or any portion of any fee hereunder payable to the Participant, (iii) reduce the amount of any such payment of principal, or (iv) reduce the rate at which interest is
payable thereon to a level below the rate at which the Participant is entitled to receive such interest. The Borrower agrees that each Participant shall be entitled to the benefits of Section 5.03 (subject to the requirements and limitations
therein, including the requirements under Section 5.03(e) (it being understood that the documentation required under Section 5.03(e) shall be delivered to the Borrower and the participating Lender)) to the same extent as if it were a
Lender and had acquired its interest by assignment pursuant to Section 13.05(c), provided that such Participant (A) agrees to be subject to the provisions of Section 5.03(g) as if it were an assignee under
Section 13.05(c); and (B) shall not be entitled to receive any greater payment under Section 5.03, with respect to any participation, than its participating Lender would have been entitled to receive, unless the sale of the
participation to such Participant is made with the Borrower’s prior written consent. To the extent permitted by Law, each Participant also shall be entitled to the benefits of Section 4.04(a) as though it were a Lender. Each Lender that
sells a participation shall, acting solely for this purpose as a non-fiduciary agent of the Borrower, maintain a register on which it enters the name and address of each Participant and the

  
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principal amounts (and stated interest) of each Participant’s interest in the Term Loans or other obligations under the Loan Documents (the “Participant Register”);
provided that no Lender shall have any obligation to disclose all or any portion of the Participant Register (including the identity of any Participant or any information relating to a Participant’s interest in any commitments, loans,
letters of credit or its other obligations under any Loan Document) to any Person except to the extent that such disclosure is necessary to establish that such commitment, loan, letter of credit or other obligation is in registered form under Section 5f.103-1(c) of the United States Treasury Regulations. The entries in the Participant Register shall be conclusive absent manifest error, and such Lender shall treat each Person whose name is recorded
in the Participant Register as the owner of such participation for all purposes of this Agreement notwithstanding any notice to the contrary. 

(g) Certain Pledges. Subject to Section 13.05(d), the Lenders may at any time pledge or assign a security interest in all or any
portion of its rights under this Agreement and any other Loan Document to secure obligations of the Lenders, including any pledge or assignment to secure obligations to a Federal Reserve Bank or another central bank; provided that no such
pledge or assignment shall release the Lenders from any of their obligations hereunder or substitute any such pledgee or assignee for the Lenders as a party hereto. 

Section 13.06. Survival. The obligations of the Borrower under Sections 5.01, 5.02, 5.03, 13.03, 13.05,
13.09, 13.10, 13.11, 13.12, 13.14, 13.15 and Article 11 (solely to the extent guaranteeing any of the obligations under the foregoing Sections) shall survive the repayment of the Obligations and the termination of the Commitments and, in the
case of any Lender’s assignment of any interest in the Commitments or the Term Loans hereunder, shall survive, in the case of any event or circumstance that occurred prior to the effective date of such assignment, the making of such assignment,
notwithstanding that such Lenders may cease to be a “Lender” hereunder. In addition, each representation and warranty made, or deemed to be made by a notice of the Term Loans, herein or pursuant hereto shall survive the making of such
representation and warranty. 
 Section 13.07. Captions. The table of contents and captions and section
headings appearing herein are included solely for convenience of reference and are not intended to affect the interpretation of any provision of this Agreement. 

Section 13.08. Counterparts. This Agreement may be executed in any number of counterparts, all of which taken
together shall constitute one and the same instrument and any of the parties hereto may execute this Agreement by signing any such counterpart. Delivery of an executed signature page of this Agreement by facsimile transmission, electronic
transmission (in PDF format) or DocuSign shall be effective as delivery of a manually executed counterpart hereof. 

Section 13.09. Governing Law. THIS AGREEMENT AND
THE OTHER LOAN DOCUMENTS, THE RIGHTS AND OBLIGATIONS OF THE PARTIES
HEREUNDER AND THEREUNDER, AND ALL CLAIMS, DISPUTES AND MATTERS ARISING HEREUNDER
OR THEREUNDER OR RELATED HERETO OR THERETO, SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK
APPLICABLE TO CONTRACTS EXECUTED IN AND TO BE PERFORMED ENTIRELY WITHIN
THAT STATE, WITHOUT REFERENCE TO CONFLICTS OF LAWS PROVISIONS (OTHER THAN
SECTION 5-1401 OF THE NEW YORK GENERAL OBLIGATIONS LAW). 

  
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 Section 13.10. Jurisdiction, Service of Process and Venue. 

(a) Submission to Jurisdiction. Each Obligor agrees that any suit, action or proceeding with respect to this Agreement or any other Loan
Document to which it is a party or any judgment entered by any court in respect thereof shall be brought in the Supreme Court of the State of New York sitting in New York County or in the United States District Court for the Southern
District of New York and irrevocably submits to the exclusive jurisdiction of each such court for the purpose of any such suit, action, proceeding or judgment. 

(b) Alternative Process. Nothing herein shall in any way be deemed to limit the ability of the Lenders to serve any such process or
summonses in any other manner permitted by applicable Law. 
 (c) WAIVER OF VENUE,
ETC. EACH OBLIGOR IRREVOCABLY WAIVES TO THE FULLEST EXTENT PERMITTED BY
LAW ANY OBJECTION THAT IT MAY NOW OR HEREAFTER HAVE TO THE
LAYING OF THE VENUE OF ANY SUIT, ACTION OR PROCEEDING ARISING OUT
OF OR RELATING TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT AND
HEREBY FURTHER IRREVOCABLY WAIVES TO THE FULLEST EXTENT PERMITTED BY LAW
ANY CLAIM THAT ANY SUCH SUIT, ACTION OR PROCEEDING BROUGHT IN ANY
SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. A FINAL JUDGMENT
(IN RESPECT OF WHICH TIME FOR ALL APPEALS HAS ELAPSED) IN ANY
SUCH SUIT, ACTION OR PROCEEDING SHALL BE CONCLUSIVE AND MAY BE
ENFORCED IN ANY COURT TO THE JURISDICTION OF WHICH SUCH OBLIGOR IS
OR MAY BE SUBJECT, BY SUIT UPON JUDGMENT. 

Section 13.11. WAIVER OF JURY
TRIAL. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE
FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO
TRIAL BY JURY IN ANY SUIT, ACTION OR PROCEEDING ARISING OUT OF
OR RELATING TO THIS AGREEMENT, THE OTHER LOAN DOCUMENTS OR THE
TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY. 

Section 13.12. WAIVER OF IMMUNITY.
TO THE EXTENT THAT ANY OBLIGOR MAY BE OR BECOME ENTITLED TO
CLAIM FOR ITSELF OR ITS PROPERTY OR REVENUES ANY IMMUNITY ON THE
GROUND OF SOVEREIGNTY OR THE LIKE FROM SUIT, COURT JURISDICTION, ATTACHMENT
PRIOR TO JUDGMENT, ATTACHMENT IN AID OF EXECUTION OF A JUDGMENT OR
EXECUTION OF A JUDGMENT, AND TO THE EXTENT THAT IN ANY SUCH
JURISDICTION THERE MAY BE ATTRIBUTED SUCH AN IMMUNITY (WHETHER OR NOT
CLAIMED), SUCH OBLIGOR HEREBY IRREVOCABLY AGREES NOT TO CLAIM AND HEREBY
IRREVOCABLY WAIVES SUCH IMMUNITY WITH RESPECT TO ITS OBLIGATIONS UNDER THIS
AGREEMENT AND THE OTHER LOAN DOCUMENTS. 

Section 13.13. Entire Agreement. This Agreement and the other Loan Documents constitute the entire agreement
among the parties with respect to the subject matter hereof and thereof and supersede any and all previous agreements and understandings, oral or written, relating to the subject matter hereof. Each Obligor acknowledges, represents and warrants that
in deciding to enter into this Agreement and the other Loan Documents or in taking or not taking any action hereunder or thereunder, it has not relied, and will not rely, on any statement, representation, warranty, covenant, agreement or
understanding, whether written or oral, of or with the Lenders other than those expressly set forth in this Agreement and the other Loan Documents. 

  
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 Section 13.14. Severability. If any provision hereof is
found by a court to be invalid or unenforceable, to the fullest extent permitted by applicable Law the parties agree that such invalidity or unenforceability shall not impair the validity or enforceability of any other provision hereof. 

Section 13.15. No Fiduciary Relationship. The Borrower acknowledges that the Lenders have no fiduciary
relationship with, or fiduciary duty to, the Borrower arising out of or in connection with this Agreement or the other Loan Documents, and the relationship between the Lenders and the Borrower are solely that of creditors and debtor. This Agreement
and the other Loan Documents do not create a joint venture among the parties. 
 Section 13.16. USA Patriot Act.
The Lenders hereby notify the Borrower that pursuant to the requirements of the USA PATRIOT Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the
“Act”), they are required to obtain, verify and record information that identifies the Borrower, which information includes the name and address of the Borrower and other information that will allow such Lender to
identify the Borrower in accordance with the Act. 
 Section 13.17. Treatment of Certain Information;
Confidentiality. The Lenders agree to maintain the confidentiality of the Information (as defined below), except that Information may be disclosed to (a) its Affiliates and to its and its Affiliates’ respective partners,
directors, officers, employees, agents, trustees, advisors and representatives (collectively, “Representatives”) (it being understood that the Persons to whom such disclosure is made will be informed of the
confidential nature of such information and instructed to keep such Information confidential), (b) to the extent requested by any regulatory authority purporting to have jurisdiction over it (including any
self-regulatory authority, such as FINRA or the National Association of Insurance Commissioners) or any exchange, (c) to the extent required by the applicable Laws or by any subpoena or similar legal
process, (d) to any other party hereto, (e) in connection with the exercise of any remedies hereunder or under any other Loan Document or any action or proceeding relating to this Agreement or any other Loan Document or the enforcement of
rights hereunder or thereunder, (f) subject to an agreement containing provisions substantially the same as those in this Section, to (i) any assignee of or Participant in, or any prospective assignee of or Participant in, any of its
rights or obligations under this Agreement or (ii) any actual or prospective counterparty (or its advisors) to any swap or derivative transaction relating to the Borrower or any Guarantor and its obligation, (g) with the consent of the
Borrower or (h) to the extent such Information (x) becomes publicly available other than as a result of a breach of this Section 13.17 or (y) becomes available to the Lender, or any of its respective Representatives on a
nonconfidential basis from a source other than the Borrower or any other Obligor. For purposes of this Section, “Information” means all information received from an Obligor relating to an Obligor or its Subsidiary or any of their
respective businesses, except that the term “Information” shall not include, and the Lenders shall not be subject to any confidentiality obligation with respect to any information that (i) is or becomes available to the Lender or any
of its Representatives on a nonconfidential basis prior to disclosure by an Obligor or its Subsidiary, (ii) becomes available to a Lender or any of its Representatives after disclosure by the Borrower or any other Obligor from a source that, to
the knowledge of such Lender, is not subject to a confidentiality obligation to the Borrower or such other Obligor, (iii) is or becomes publicly available other than as a result of a breach by such Lender, or (iv) is developed by a Lender
or any of its Representatives. Any Person required to maintain the confidentiality of Information as provided in this Section shall be considered to have complied with its obligation to do so if such Person has exercised the same degree of care to
maintain the confidentiality of such Information as such Person would accord to its own confidential information. 

  
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 In the case of any Lender that has elected to receive material non-public information pursuant to Section 8.02, such Lender acknowledges that (a) the Information may include material non-public information concerning an Obligor
or its Subsidiary, as the case may be, (b) it has developed compliance procedures regarding the use of material non-public information and (c) it will handle such material non-public information in accordance with applicable Law, including United States federal and state securities Laws. 

Section 13.18. Releases of Guarantees and Liens. (a) Notwithstanding anything to the contrary contained
herein or in any other Loan Document, each Lender agrees, and the Administrative Agent is hereby irrevocably authorized by each Lender and given a limited power of attorney by each Lender to perform the actions described hereafter in this
Section 13.18 (without requirement of notice to or consent of any Lender except as expressly required by Section 13.04) to take any action reasonably requested by the Borrower having the effect of releasing any Collateral or Obligations
(i) to the extent necessary to permit consummation of any transaction not prohibited by any Loan Document or that has been consented to by the Lenders or (ii) under the circumstances described in paragraph (b) below. 

(b) At such time as the Term Loans and the other Obligations (other than the inchoate indemnity obligations and the Warrant Obligations) under
the Loan Documents shall have been paid in full in cash and the Commitments have been terminated, the Collateral shall be released from the Liens created by the Security Documents, and the Security Documents and all obligations (other than those
expressly stated to survive such termination) of the Administrative Agent and each Obligor under the Security Documents shall terminate, all without delivery of any instrument or performance of any act by any Person. 

Section 13.19. Acknowledgement and Consent to Bail-In of EEA
Financial Institutions. Notwithstanding anything to the contrary in any Loan Document or in any other agreement, arrangement or understanding among any such parties, each party hereto acknowledges that any liability of any EEA Financial
Institution arising under any Loan Document, to the extent such liability is unsecured, may be subject to the write-down and conversion powers of an EEA Resolution Authority and agrees and consents to, and
acknowledges and agrees to be bound by: 
 (a) the application of any Write-Down and
Conversion Powers by an EEA Resolution Authority to any such liabilities arising hereunder which may be payable to it by any party hereto that is an EEA Financial Institution; and 

(b) the effects of any Bail-In Action on any such liability, including, if applicable:

 (i) a reduction in full or in part or cancellation of any such liability; 

  
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 (ii) a conversion of all, or a portion of, such liability into shares or
other instruments of ownership in such EEA Financial Institution, its parent undertaking, or a bridge institution that may be issued to it or otherwise conferred on it, and that such shares or other instruments of ownership will be accepted by it in
lieu of any rights with respect to any such liability under this Agreement or any other Loan Document; or 
 (iii) the
variation of the terms of such liability in connection with the exercise of the write-down and conversion powers of any EEA Resolution Authority. 

[Remainder of the Page Intentionally Left Blank; Signature Pages Follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have
caused this Agreement to be duly executed and delivered as of the day and year first above written. 
  

			
	BORROWER:
	
	C4 THERAPEUTICS, INC.
		
	By:	 	 /s/ Marc Cohen

		 	Name: Marc Cohen
		 	Title: Chief Executive Officer
	
	Address for Notices:
	
	490 Arsenal Way, Suite 200
	Watertown, MA 02472
	
	with a copy to (which shall not constitute notice):
	
	Goodman Procter LLP
	100 Northern Avenue
	Boston, MA 02210
	Attention: Mark D. Smith
	E-mail: marksmith@goodwinlaw.com

 [Signature Page to Credit Agreement and Guaranty] 

 LENDERS: 

PERCEPTIVE CREDIT HOLDINGS III, LP 

By: Perceptive Credit Opportunities GP, LLC, its general partner 
  

			
	By:	 	 /s/ Sandeep Dixit

	Name:	 	Sandeep Dixit
	Title:	 	Chief Credit Officer
		
	By:	 	 /s/ Sam Chawla

	Name:	 	Sam Chawla
	Title:	 	Portfolio Manager

 Address for Notices: 

Perceptive Credit Holdings III, LP 
 c/o Perceptive Advisors LLC

 51 Astor Place 
 10th Floor 

New York, New York 10003 
 Attention: Sandeep Dixit 

E-mail: Sandeep@perceptivelife.com; PCOFReporting@perceptivelife.com 

with a copy to: 
 Chapman and Cutler LLP 

1270 Avenue of the Americas 
 30th Floor 

New York, New York 10020-1708 

Attention: Nicholas Whitney 

E-mail: Whitney@chapman.com 

[Signature Page to Credit Agreement and Guaranty] 

 ADMINISTRATIVE AGENT: 

PERCEPTIVE CREDIT HOLDINGS III, LP 

By: Perceptive Credit Opportunities GP, LLC, its general partner 
  

			
	By:	 	 /s/ Sandeep Dixit

	Name:	 	Sandeep Dixit
	Title:	 	Chief Credit Officer
		
	By:	 	 /s/ Sam Chawla

	Name:	 	Sam Chawla
	Title:	 	Portfolio Manager

 Address for Notices: 

Perceptive Credit Holdings III, LP 
 c/o Perceptive Advisors LLC

 51 Astor Place 
 10th Floor 

New York, New York 10003 
 Attention: Sandeep Dixit 

E-mail: Sandeep@perceptivelife.com; PCOFReporting@perceptivelife.com 

with a copy to: 
 Chapman and Cutler LLP 

1270 Avenue of the Americas 
 30th Floor 

New York, New York 10020-1708 

Attention: Nicholas Whitney 

E-mail: Whitney@chapman.com 

[Signature Page to Credit Agreement and Guaranty] 

[Exhibits are Omitted.]EX-10.9

 Exhibit 10.9 

Execution Copy 
 LEASE 

BY 
 480 ARSENAL GROUP
LLC, LANDLORD 
 TO 

C4 THERAPEUTICS, INC., TENANT 
  

 
 LINX Building 

490 Arsenal Way 
 Watertown,
Massachusetts 02472 

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
	 ARTICLE 1: BASIC TERMS
	  	 	1	 
	 ARTICLE 2: PREMISES, APPURTENANT RIGHTS AND RIGHT OF FIRST OFFER
	  	 	4	 
	 2.01. Lease of Premises; Appurtenant Rights
	  	 	4	 
	 2.01(a) General
	  	 	4	 
	 2.01(b) Exclusions
	  	 	4	 
	 2.01(c) Appurtenant Rights
	  	 	4	 
	 2.01 (d) Reservations
	  	 	4	 
	 2.01 (e) Measurement.
	  	 	5	 
	 2.01(f) H3 Room; PH Systems; Control Areas; Bulk Tanks
	  	 	5	 
	 2.01 (g) Parking
	  	 	5	 
	 2.02. Right of First Offer
	  	 	6	 
	 ARTICLE 3: LEASE TERM
	  	 	8	 
	 3.01. Lease Term; Construction
	  	 	8	 
	 3.02. Hold Over
	  	 	8	 
	 3.03. Right to Extend
	  	 	9	 
	 3.03(a) Extension Term
	  	 	9	 
	 3.03(b) Extension Term Base Rent
	  	 	9	 
	 3.03(c) Determination of Fair Market Rent
	  	 	9	 
	 3.03(d) Rent Continuation
	  	 	10	 
	 ARTICLE 4: RENT
	  	 	10	 
	 4.01. Base Rent
	  	 	10	 
	 4.02. Additional Rent
	  	 	10	 
	 4.02(a) General
	  	 	10	 
	 4.02(b) Allocation of Certain Operating Costs
	  	 	11	 
	 4.03. Late Charge
	  	 	11	 
	 4.04. Interest
	  	 	11	 
	 4.05. Method of Payment
	  	 	11	 
	 4.06. Tenant’s Pro Rata Share
	  	 	12	 
	 ARTICLE 5: TAXES
	  	 	12	 
	 5.01. Taxes
	  	 	12	 
	 5.02. Definition of “Taxes”
	  	 	12	 
	 5.03. Personal Property Taxes
	  	 	13	 
	 ARTICLE 6: BUILDING SERVICES AND SPECIAL BUILDING FACILITIES
	  	 	13	 
	 6.01. Utility Services
	  	 	13	 
	 6. 02. Building Services and Building Systems
	  	 	14	 
	 6.03. Service Interruptions
	  	 	16	 
	 ARTICLE 7: OPERATING EXPENSES
	  	 	17	 
	 7.01. Operating Expenses
	  	 	17	 
	 ARTICLE 8: INSURANCE
	  	 	20	 
	 8.01. Coverage
	  	 	20	 
	 8.02 Avoid Action Increasing Rates
	  	 	21	 
	 8.03. Waiver of Subrogation
	  	 	21	 
	 8.04. Landlord’s Insurance
	  	 	21	 
	 ARTICLE 9: USE OF PREMISES
	  	 	22	 
	 9.01. Permitted Uses
	  	 	22	 

  
 i 

					
	 9.02. Indemnification
	  	 	22	 
	 9.03. Compliance With Legal Requirements
	  	 	22	 
	 9.04. Hazardous Substances
	  	 	23	 
	 9.05. Signs
	  	 	26	 
	 9.06. Landlord’s Access
	  	 	26	 
	 9.07. Landlord’s Rules and Regulations
	  	 	27	 
	 9.08. Compliance With Insurance Requirements
	  	 	27	 
	 9.09. Floor Load; Heavy Machinery
	  	 	27	 
	 9.10. LEED/Energy Conservation Measures
	  	 	27	 
	 9.11. Emergency Generator
	  	 	28	 
	 9.12. Rooftop Rights
	  	 	30	 
	 ARTICLE 10: CONDITION AND MAINTENANCE OF PREMISES AND PROPERTY
	  	 	31	 
	 10.01. Existing Conditions
	  	 	31	 
	 10.02. No Landlord Liability
	  	 	31	 
	 10.03. Landlord’s Repair and Maintenance Obligations
	  	 	32	 
	 10.04. Tenant’s Obligations
	  	 	32	 
	 10.04(a) Repair and Maintenance
	  	 	32	 
	 10.04(b) Landlord’s Right to Cure.
	  	 	33	 
	 10.05. Tenant Work
	  	 	33	 
	 10.05(a) General
	  	 	33	 
	 10.05(b) Construction Documents
	  	 	34	 
	 10.05(c) Performance
	  	 	34	 
	 10.05(d) Payment
	  	 	35	 
	 10.05(e) Other
	  	 	35	 
	 10.05(f) Removal at Conclusion of Term
	  	 	36	 
	 10.05(g) Initial Tenant Work
	  	 	36	 
	 10.06. Condition upon Termination
	  	 	36	 
	 10.07. Decommissioning of the Premises
	  	 	37	 
	 ARTICLE 11: DAMAGE OR DESTRUCTION CONDEMNATION
	  	 	38	 
	 11.01. Damage or Destruction of Premises
	  	 	38	 
	 11.02. Eminent Domain
	  	 	38	 
	 ARTICLE 12: ASSIGNMENT AND SUBLETTING
	  	 	39	 
	 12.01. Landlord’s Consent Required
	  	 	39	 
	 12.02. Terms
	  	 	40	 
	 12.03. Related Party Transfers
	  	 	40	 
	 12.04. Procedures
	  	 	40	 
	 12.05. Excess Rents
	  	 	40	 
	 12.06. No Release
	  	 	41	 
	 ARTICLE 13: EVENTS OF DEFAULT AND REMEDIES
	  	 	41	 
	 13.01. Event Default
	  	 	41	 
	 13.02. Remedies for Default
	  	 	43	 
	 13.02(a) Reletting Expenses Damages
	  	 	43	 
	 13.02(b) Termination Damages
	  	 	43	 
	 13.02(c) Lump Sum Liquidated Damages
	  	 	43	 
	 13.02(d) Remedies Cumulative; Late Performance
	  	 	43	 
	 13.02(e) Landlord’s Curing
	  	 	43	 
	 ARTICLE 14: SECURITY DEPOSIT
	  	 	44	 
	 ARTICLE 15: PROTECTION OF LENDERS/GROUND LANDLORD
	  	 	45	 
	 15.01. Subordination and Superiority of Lease
	  	 	45	 
	 15.02. Rent Assignment
	  	 	46	 
	 15.03. Other Instruments
	  	 	46	 

  
 ii 

					
	 15.04. Estoppel Certificates
	  	 	47	 
	 15.05. Financial Condition
	  	 	47	 
	 ARTICLE 16: MISCELLANEOUS PROVISIONS
	  	 	47	 
	 16.01. Landlord’s Consent Fees
	  	 	47	 
	 16.02. Landlord’s Default
	  	 	47	 
	 16.03. Quiet Enjoyment
	  	 	48	 
	 16.04. Interpretation
	  	 	48	 
	 16.05. Notices
	  	 	48	 
	 16.06. No Recordation
	  	 	48	 
	 16.07. Corporate Authority
	  	 	48	 
	 16.08. Joint and Several Liability
	  	 	48	 
	 16.09. Force Majeure
	  	 	48	 
	 16.10. No Warranties; Limitation of Landlord’s Liability
	  	 	49	 
	 16.10(a) No Warranties
	  	 	49	 
	 16.10(b) Limitation On Landlord’s Liability
	  	 	49	 
	 16.11. No Brokers
	  	 	49	 
	 16.12. No Waiver; Accord and Satisfaction
	  	 	49	 
	 16.13. Applicable Law and Construction
	  	 	50	 
	 16.14. Waiver of Trial by Jury
	  	 	50	 
	 16.15. No Representations or Inducements
	  	 	50	 
	 16.16. No Surrender
	  	 	50	 
	 16.17. Arbitration
	  	 	51	 
	 16.17(a.) Initial Construction Disputes
	  	 	51	 
	 16.17(b) Arbitration Procedures
	  	 	51	 
	 16.18. Patriot Act
	  	 	52	 

  
 iii 

 LEASE 

ARTICLE 1: BASIC TERMS 
 The following terms used in this
Lease shall have the meanings set forth below. Other terms are defined throughout this Lease and indexed on
 Schedule 1 attached hereto and made a part hereof. 
  

			
	Date of Lease:	  	As of July 5, 2017
		
	Landlord:	  	480 Arsenal Group LLC,
		  	a Massachusetts limited liability company
		
	Original Address of Landlord:	  	c/o Boylston Properties
		  	800 Boylston Street, Suite 1390
		  	Boston, Massachusetts 02199
		  	Attention: Mark A. Deschenes
		
		  	With copies to:
		
		  	Sherin and Lodgen, LLP
		  	101 Federal Street
		  	Boston Massachusetts 02110
		  	Attention: Peter Friedenberg, Esq.
		
	Tenant:	  	C4 Therapeutics, Inc.,
		  	a Delaware corporation
		
	Original Address of Tenant:	  	675 West Kendall Street
		  	Cambridge, Massachusetts 02142
		  	Attention: President
		
		  	With copies to:
		
		  	Krokidas & Bluestein LLP
		  	Attention: Kathryn Murphy, Esq.
		  	600 Atlantic Avenue, 19th Floor
		  	Boston, MA 02210
		
		  	and:
		
		  	Goodwin Proctor LLP
		  	Attention: Lawrence S. Wittenberg
		  	53 State Street
		  	Boston, MA 02109
		
	Guarantor:	  	N/A
		
	Address of Property:	  	490 Arsenal Way
		  	Watertown, Massachusetts 02472

			
		
	Building and Property:	  	The building Known as and numbered 490 Arsenal Way, containing a total rentable area of approximately 185,015 rentable square feet (“Building”), in the City Known as the Town of Watertown, Massachusetts, situated on
a parcel of land described in Exhibit A attached hereto (the Building and such parcel of land, together with all other improvements now or hereafter located thereon, are collectively referred to as the
(“Property”)).
		
	Premises:	  	A total rentable area of 45,559 rentable square feet, consisting of 463 rentable square feet on the first floor of the West Wing of the Building and 45,096 rentable square feet on the second floor of the West Wing of the Building,
as shown on Exhibit B attached hereto, as measured in accordance with the provisions of Section 2.01(e).
		
	Tenant’s Pro Rata Share:	  	24.62%. See Section 4.06.
		
	Term Commencement Date:	  	The date on which both (a) this Lease is executed and unconditionally delivered by both Landlord and Tenant, and (b) the Letter of Credit is delivered to Landlord.
		
	 Term:

      Initial Term:
	  	The period commencing on the Term Commencement Date and expiring on the day (“Termination Date”) which is the last day of the tenth (10th) Lease Year.
		
	      Extension Term:	  	One (1) extension term of five (5) Lease Years. See Section 3.03(a).
		
	Rent Commencement Date:	  	May 1, 2018.
		
	Lease Year:	  	The first Lease Year begins at 12:01 a.m. on May 1, 2018 and ends at 11:59 p.m. on April 30, 2019. Each subsequent Lease Year ends at 11:59 p.m. 12 months after the preceding Lease Year.
		
	Estimated Delivery Date:	  	July 1, 2017
		
	Permitted Uses:	  	General office, laboratory, research and development, and any other lawful use, all to the extent permitted under the watertown Zoning Ordinance as in effect from time to time.
		
	Landlord’s Broker:	  	Cushman & Wakefield
		
	Tenant’s Broker:	  	Jones Lang LaSalle
		
	Security Deposit:	  	Letter of Credit in the amount of $2,577,150.00.

  
 2 

			
	Parking Allotment:	  	Parking spaces at a ratio of 3.1 parking spaces per 1,000 rentable square feet in the Premises (initially, 141 parking spaces), including ten (10) reserved covered spaces initially located as shown on Exhibit A attached
hereto. See Section 2.01(g).
		
	 Base Rent:

      Initial Term:
	  	The following amounts:

  

													
	 Period
	  	Rate per
rentable s.f.	 	  	Monthly
Amount	 	  	Annual Amount	 
	 Rent Commencement Date to 12/31/2019
	  	$	47.00	 	  	$	178,439.42	 	  	$	2,141,273.00	 
	 1/1/2020 -12/31/2020
	  	$	48.41	 	  	$	183,792.60	 	  	$	2,205,511.19	 
	 1/1/2021 -12/31/2021
	  	$	49.86	 	  	$	189,297.65	 	  	$	2,271,571.74	 
	 1/1/2022 - 12/31/2022
	  	$	51.36	 	  	$	194,992.52	 	  	$	2,339,910.24	 
	 1/1/2023 - 12/31/2023
	  	$	52.90	 	  	$	200,839.26	 	  	$	2,410,071.11	 
	 1/1/2024 - 12/31/2024
	  	$	54.49	 	  	$	206,875.83	 	  	$	2,482,509.91	 
	 1/1/2025 -12/31/2025
	  	$	56.12	 	  	$	213,064.26	 	  	$	2,556,771.08	 
	 1/1/2026 -12/31/2026
	  	$	57.80	 	  	$	219,442.52	 	  	$	2,633,310.20	 
	 1/1/2027 -12/31/2027
	  	$	59.53	 	  	$	226,010.61	 	  	$	2,712,127.27	 
	 1/1/2028 -Termination Date
	  	$	61.32	 	  	$	232,806.49	 	  	$	2,793,677.88	 

  

					
	      Extension Term:	  	Fair Market Rent (as defined in Section 3.03(b).
		
	Initial Tenant Work:	  	As set forth in Exhibit C attached hereto.
		
	Base Building Work:	  	As set forth in Exhibit C attached hereto.
			
	Exhibits:	  	Schedule 1:	  	Index of Defined Terms
		  	Exhibit A (Art 1):	  	The Property
		  	Exhibit B (Art. 1):	  	Building Floor Plan showing the Premises
		  	Exhibit C (Sec. 3.01):	  	Work Letter
		  	Exhibit C-1 (Sec. 2.01(e)):	  	List of Base ‘Building Plans and Specifications
		  	Exhibit C-2:	  	Tenant’s Initial Test Fit Plan
		  	Exhibit C-3:	  	Lab Shell Specifications Tenant Landlord Matrix of Responsibility
		  	Exhibit C-4:	  	Preliminary Construction Schedule
		  	Exhibit D:	  	Intentionally deleted
		  	Exhibit E (Sec. 6.02):	  	Cleaning Specification for Common Areas and Landlord Services
		  	Exhibit F (Sec. 6.02):	  	Shuttle Service
		  	Exhibit G (Sec. 9.07):	  	Rules and Regulations
		  	Exhibit H (Sec. 10.05(b)):	  	Construction Documents Requirements
		  	Exhibit I (Sec. 10.05(c)):	  	Tenant Work Insurance Schedule
		  	Exhibit J (Sec. 15.01):	  	Form of SNDA
		  	Exhibit K (Sec. 15.04):	  	Form of Estoppel Certificate
		  	Exhibit L (Sec. 9.05):	  	Exterior Signage
		  	Exhibit M (Sec. 16.06):	  	Form of Notice of Lease

  
 3 

 ARTICLE 2: PREMISES, APPURTENANT RIGHTS AND RIGHT OF FIRST OFFER 

2.01. Lease of Premises; Appurtenant Rights. 

(a) General. Landlord hereby leases the Premises to Tenant, and Tenant hereby leases the Premises from Landlord, for the Term. Subject
to Landlord’s Rules and Regulations and the provisions of this Lease, Tenant shall have access to the Premises, the parking areas serving the Premises, and the common areas of the Building and the Property necessary for Tenant’s use of, or
access to and egress from, the Premises 24 hours a day, 7 days a week; provided, however, that in times of emergency as determined by Landlord, Landlord shall have the right to limit access to the Building by Tenant and all other tenants,
provided that any such limits on access shall cease as soon as the emergency is resolved and Landlord shall use commercially reasonable efforts to limit interference with Tenant’s business in connection with any exercise of its rights
hereunder. For purposes of this Lease, an “emergency” shall mean an event, such as a natural disaster, fire or act of terrorism, not within the reasonable control of either party hereto, that poses an immediate threat to life or the
Property. 
 (b) Exclusions. The Premises exclude the perimeter walls thereof (other than the inner surfaces thereof), as well as all
common areas and facilities of the Property, including the common stairways and stairwells, entranceways and the main lobby, elevators and elevator wells, fan rooms, roofs, off-floor electric and off-floor telephone closets, freight elevators, and pipes, ducts, conduits, wires and appurtenant fixtures serving other parts of the Property (exclusively or in common) and other common areas and facilities from
time to time designated as such by Landlord. If the Premises includes less than the entire rentable area of any floor, then the Premises also exclude the common corridors, elevator lobby, and toilets (with the exception of those restrooms located
entirely within the Premises and for the exclusive use of Tenant) located on such floor, as well as common on-floor electric, telephone and janitor closets located on such floor. 

(c) Appurtenant Rights. Tenant shall have, as appurtenant to the Premises, the right to use in common with others, and subject to
Landlord’s Rules and Regulations: (a) the common areas and facilities of the Building, including the common loading docks, lobbies, hallways, stairways and elevators of the Building serving the Premises in common with other portions of the
Building, the bike repair and storage room on the first floor of the Building, showers and lockers located on the first floor of the Building and other Building amenities, (b) common sidewalks, walkways and roadways necessary for access to the
Building, (c) if the Premises include less than the entire rentable area of any floor, the common toilets and other common facilities of such floor; and no other appurtenant rights or easements, (d) wireless internet access provided in the
common areas of the Building, and (e) the risers, conduits and roof areas of the Building for Tenant’s business, telecommunications and computer needs, which roof areas are subject to Section 9.12. All costs,
charges and expenses associated with the commencement of the provision by a particular utility service provider or telecommunications service provider of service to Tenant or to the Premises at the request of Tenant (e.g., installation charges,
service deposits) shall be the sole responsibility of Tenant. 
 (d) Reservations. In addition to other rights reserved herein or by
law, Landlord reserves the right from time to time, without incurring any liability to Tenant or otherwise affecting Tenant’s obligations under this Lease, provided that Landlord shall provide at least forty-eight (48) hours prior notice
to Tenant (except in the case of an emergency, in which case notice shall be provided as soon as reasonably practicable) and shall use commercially reasonable efforts to avoid (except in emergency) interruption of Tenant’s use and access to the
Premises: (i) to make additions, alterations, improvements, repairs or replacements to the Building, including all common areas and facilities located therein; (ii) to install, use, maintain, repair, replace and relocate for service to the
Premises and other parts of the Building, or either, chases, shafts, pipes, ducts, conduits, wires and appurtenant fixtures wherever located in the Premises, the Building or elsewhere in the Property; (iii) to alter, eliminate or relocate any
common area or facility, including the lobbies and entrances; and (iv) to grant easements and other rights with respect to the Property; provided that (a) to the maximum extent practicable, no such installations, replacements or
relocations in the Premises shall be placed below ceiling surfaces, above floor surfaces or to the inside of perimeter walls, (b) Tenant’s use of and access to the Premises, the common areas and its parking spaces shall not be adversely
impacted by any such additions, alterations, improvements, repairs, installations, replacements or relocations, and Tenant shall continue to have rights to use a bike repair and storage room, showers, lockers, and wireless internet access in the
Building and to the risers, conduits and roof areas of the Building for Tenant’s business, telecommunications and computer needs, subject to the applicable provisions of this Lease, and (c) all such work necessitating entry into the
Premises shall be subject to the provisions of Section 9.06. 

  
 4 

 This Lease, and Tenant’s leasehold interest in the Premises, are subject to all rights,
agreements, easements, restrictions and matters of record and all agreements applicable to the Property which have been executed as of the Date of Lease and which have been, prior to the Date of Lease, either provided to Tenant or recorded with the
Middlesex South Registry of Deeds; and all permits and approvals for the construction and/or use of the Building. 
 (e) Measurement.
The total rentable area of the Premises set forth in Article 1 has been determined by (i) measuring the usable area of the same based on the proposed location of the demising walls of the Premises as shown on Exhibit B attached
hereto, using the BOMA International Standard Method of Measurement for Office Buildings (ANSI/BOMA Z65.1-2010) (the “Measurement Standard”) and (ii) applying an add-on factor of 18.3% thereto. Landlord shall have the right to re-measure the Premises and re-calculate the rentable area of the
Premises or any portion thereof in accordance with the foregoing methodology (and to re-calculate the Tenant’s Pro Rata Share, Base Rent, and any other amount set forth in the Lease or the Work Letter
which is dependent upon the rentable area of the Premises or any portion thereof) only at such time as (i) Tenant’s Space Plan is approved by Landlord pursuant to the Work Letter, or (ii) Landlord determines the final size of the H3
Room and the portion thereof dedicated to Tenant’s exclusive use, or (iii) Tenant leases ROFO Space pursuant to Tenant’s ROFO Right. Upon request of either party, the parties shall promptly execute an amendment to this Lease
confirming any such change in the rentable area of the Premises or any portion thereof and any corresponding change in Tenant’s Pro Rata Share, Base Rent, and any other amount set forth in the Lease or the Work Letter which is dependent upon
the rentable area of the Premises or any portion thereof. 
 (f) H3 Room; PH System; Control Areas; Bulk Tanks.  

(i) As part of the Base Building Work, Landlord shall construct on the first floor of the Building (including fireproofing), at the location
identified on Exhibit A attached hereto or in another location hereafter designated by Landlord in proximity to the loading dock and reasonably acceptable to Tenant, a common “Control Area” (as defined in the International Building
Code and International Fire Code) for use by lab tenants of the Building for the temporary storage of Hazardous Materials to be used in the tenants’ leased premises within the Building (the “H3 Room”). The H3 Room shall be
built to comply with H3 hazard use requirements. Landlord shall designate a portion of the H3 Room containing approximately 154 square feet of rentable area (“Tenant’s H3 Space”) for Tenant’s exclusive use (subject to
remeasurement as provided in Section 2.01(e) above), which space shall be demised from the remainder of the H3 Room and shall constitute part of the Premises for all purposes of this Lease. 

(ii) Tenant shall construct as part of the Initial Tenant Work pursuant to the Work Letter, an acid neutralization system within the portion of
the Premises situated on the first floor of the Building as shown on Exhibit B attached hereto or in another location within the Premises agreed upon by the parties. 

(iii) The parties have agreed that there will be two “Control Areas” within the Premises on the second floor of the Building, and one
“Control Area” (the H3 Room) on the first floor of the Building. Landlord shall pay all costs of installing the required fireproofing for such “Control Areas,” in addition to (and not as part of) providing the Landlord Allowance.

 (iv) In addition, Landlord shall make available to Tenant, in a mutually agreeable location near the loading dock within which Landlord
can fit this facility (see the proposed location shown on Exhibit A, Detail Page 2 as “Common Inert Gas Tank Enclosure (approx. location)”), exterior space for the installation of tanks to accommodate the storage of bulk nitrogen and
carbon dioxide, which storage space may be included within a common storage space also used by other tenants of the Building for similar tank storage. 

(g) Parking. 
 (i) During
the Term, Tenant shall have the appurtenant right to use, at no additional charge, the total number of parking spaces (such amount, the “Parking Allotment”) set forth in Article 1 in the garage (the “Parking
Garage”) and/or surface parking areas (collectively, with the Parking Garage, the “Parking Facilities”) serving the Building, in common with all persons now or hereafter entitled to use the same. These parking spaces shall
be used only by Tenant and Tenant’s employees and business invitees for the parking of passenger vehicles only. At no time may Tenant use more parking spaces in the Parking Facilities than the Parking Allotment. 

  
 5 

 (ii) Subject to the provisions of clause (iii) below, use of the parking spaces in the
Parking Facilities shall be on a non-exclusive, non-reserved basis. The provisions of this Lease, including Landlord’s Rules and Regulations, shall apply to the
Parking Facilities and Tenant’s use thereof. Landlord shall have the right to alter the Parking Garage or any other portion of the Parking Facilities, or the operation thereof, from time to time, and to temporarily close portions thereof for
maintenance, repair or improvement, as necessary; provided, however, that (i) Landlord shall provide at least two weeks’ prior notice (except in the case of an emergency, in which event notice shall be provided as soon as reasonably
practicable) to Tenant of any such closure, and (ii) Landlord shall use reasonable efforts to minimize interference with Tenant’s use and access to the Premises during any such closure, (iii) if such closure reduces the number of
usable parking spaces in the Parking Facilities by twenty percent (20%) or more, Landlord shall provide alternative parking for Tenant in the amount of at least the portion of the Parking Allotment not available to Tenant at the Parking Facilities
during any such closure and, if such parking is not within a reasonable walking distance from the Premises, shall provide regular shuttle service between the Building and the alternative parking area, during the hours of 6:00 am to 10:00 am and 4:00
pm to 7:00 pm Monday through Friday, and (iv) to the extent that the closure lasts for a period of ten (10) consecutive Business Days or more, Tenant shall have the right to consent to any such closure. 

(iii) Tenant’s employees and visitors shall have the right to use, as part of the Parking Allotment, up to ten (10) designated
parking spaces situated in the Garage initially at the location identified on Exhibit A attached hereto. Landlord shall have the right to relocate such spaces from time to time provided that such relocated spaces are in reasonably comparable
proximity to the Building entrance and exit nearest to the Premises. Landlord, at Landlord’s sole expense, shall install signage identifying the designated spaces as devoted to Tenant’s exclusive use. Promptly following receipt of notice
from Tenant that an unauthorized vehicle is parked in one of the parking spaces designated for Tenant’s exclusive use, Landlord shall arrange for the removal of such vehicle. 

(iv) None of Tenant’s rights under this Section may be assigned, subleased or otherwise transferred except in connection with a Transfer
or Related Party Transfer effected in accordance with the provisions of Article 12 below. Neither Landlord nor any operator of the Parking Facilities shall be responsible for any loss or damage due to fire or theft or otherwise to any
automobile parked in the Parking Facilities or to any personal property therein. 
 (v) Tenant acknowledges receipt of copies of
(i) that certain License Agreement dated as of April 7, 2017 by and between Landlord and the Armenian Cultural and Educational Center, Inc. pursuant to which the owner’ of the property at 47 Nichols Avenue, Watertown, Massachusetts
has the right to use a portion of the parking spaces in the Parking Facilities on Monday through Friday between the hours of 6:00 p.m. and midnight, on Saturday between the hours of 8:00 a.m. and 2:00 a.m. (Sunday morning), and on Sunday between the
hours of 8:00 am and midnight, to which this Lease is subject, and (ii) that certain License Agreement dated May 2016 by and between Landlord and the Commonwealth of Massachusetts, acting by and through the Department of Conservation and
Recreation, concerning the land owned by the Commonwealth adjacent to the Property (collectively, the “Agreements”).  

2.02. Right of First Offer. 

(a) If at any time during the Term of this Lease, any space on the second floor of the West Wing of the Building (the “ROFO
Space”) becomes available for occupancy upon the expiration or earlier termination of the lease therefor between Landlord and a third party tenant (and provided that both (i) Tenant is not then in default hereunder beyond all
applicable notice and grace periods (if any), and (ii) the Tenant named in Article 1 above is then occupying at least ninety percent (90%) of the Premises for the conduct of the Permitted Uses), Tenant shall have the right of first offer
to lease any such ROFO Space subject to and in accordance with the terms and conditions set forth in this Section 2.02 (“Tenant’s ROFO Right”). If at any time any ROFO Space shall become available for
occupancy, Landlord shall notify Tenant thereof in writing (“Landlord’s ROFO Space Notice”), which notice shall include (i) the anticipated estimated date upon which such ROFO Space shall become available for occupancy by
Tenant (the “ROFO Commencement Date”), (ii) a floor plan showing the approximate rentable square footage thereof, and (iii) Landlord’s determination of the Fair Market Rent for such ROFO Space for a period coterminous with
the Term of this Lease. Tenant shall have the right only to lease all such ROFO Space described in Landlord’s ROFO Space Notice (and not less than all of such ROFO Space) by giving written notice to Landlord (“Tenant’s ROFO
Acceptance Notice”) within fifteen (15) days after Tenant receives Landlord’s ROFO Space Notice, time being of the essence. If Tenant so elects to lease the subject ROFO Space, such ROFO Space shall be leased by Landlord to Tenant
upon the same terms and conditions contained in this Lease, except that: (A) Base Rent for the subject ROFO Space shall be equal to the Fair Market Rent therefor determined in accordance with Section 3.03(c) below
(made applicable hereto by such changes and modifications as are required given the application hereof), (B) the subject ROFO Space shall be and become part of the Premises hereunder upon the delivery of such ROFO Space to Tenant, and (C) it is
understood and agreed that, unless otherwise expressly provided in Landlord’s ROFO Notice, the subject ROFO Space shall be leased by Tenant in its then “as-is”,
“where-is” condition, without warranty or representation by Landlord and Landlord shall have no obligation to complete any work to prepare the applicable ROFO Space for Tenant’s use and
occupancy or provide any allowance or contribution therefor. Following such election by Tenant, and effective as of the delivery of the applicable ROFO Space and for the balance of the Term of this Lease and any

  
 6 

 
extension thereof: (x) the “Premises”, as used in this Lease, shall include the applicable ROFO Space; (y) any Additional Rent, charges and expenses due under this Lease and
the number of parking spaces to which Tenant shall be entitled in the Parking Facilities shall be re-calculated to reflect the inclusion of the ROFO Space; and (z) the Base Rent shall equal the sum of the
then current Base Rent provided for in this Lease plus the Base Rent for the applicable ROFO Space as determined herein. The foregoing provisions of this Section 2.02(a) shall be self-executing, but the parties 

  
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 agree that for purposes of confirming the foregoing, Landlord shall prepare, and Tenant and Landlord shall
promptly execute and deliver, an amendment to this Lease in form reasonably acceptable to both parties reflecting the foregoing terms and the incorporation of any ROFO Space. For the purposes hereof, space shall be deemed “available for
occupancy” when (1) any lease or occupancy agreement (including extension periods thereunder) for such ROFO Space has expired or is due to expire within not less than six (6) months, (2) any expansion options, expansion rights or
other rights to lease with respect to such ROFO Space which are set forth in any other lease or leases entered into prior to the date hereof have expired or been waived, and (3) Landlord is free to, and intends to, lease such space to third
parties without restriction. 
 (b) If Tenant fails to timely exercise any of its rights hereunder, the right(s) granted hereunder as to the
applicable ROFO Space shall be deemed waived for the period set forth in this subsection (b) with respect to such ROFO Space, and Landlord may lease the applicable ROFO Space during such time to any party and upon terms substantially similar to
the terms offered to Tenant in Landlord’s ROFO Space Notice (including that the effective rental rate under such lease is at least ninety percent (90%) of the effective Rent offered to Tenant), free of any rights of Tenant. Tenant, following
such waiver and within seven (7) Business Days of Landlord’s request therefor, shall execute and deliver to Landlord a certification, in recordable form, confirming the waiver of such right (or if Tenant in good faith disputes that it has
so waived such right, Tenant shall so notify Landlord in writing within such 7-Business Day period). Provided that Landlord’s request specifies, in capitalized, boldfaced type in the first paragraph
thereof, that Tenant’s failure to so execute and deliver such certification (or to send notice of such dispute) shall (without limiting Landlord’s remedies on account thereof) entitle Landlord to execute and deliver to any third party, and
record, an affidavit confirming such waiver, then such failure to respond by Tenant shall entitle Landlord to do so, in which event such affidavit shall be binding on Tenant and may be conclusively relied on by third parties. Notwithstanding the
foregoing, if Landlord fails to execute a lease of such ROFO Space within twelve (12) months following the expiration of the 15-day period referenced in Section 2.02(a) above, or
if Landlord intends on accepting an offer to lease the ROFO Space at an effective rental rate that is less than ninety (90%) percent of the effective Rent offered to Tenant, then Landlord shall be required to again offer to lease the ROFO Space to
Tenant in accordance with the terms hereof prior to leasing the same to a third party. 
 (c) The foregoing Tenant’s ROFO Right may only
be exercised by the Tenant named in Article 1 above or a Related Party Transferee (in which latter case all references in this Section 2.02 to “Tenant” shall be deemed to refer to such Related Party Transferee). Tenant
acknowledges and agrees that its rights under this Section are and shall be subject and subordinate to any extension rights granted in (i) the initial lease by Landlord to a third party of each portion of the ROFO Space, and (ii) any lease
thereafter entered into by Landlord with a third party with respect to any portion of the ROFO Space in accordance with the provisions of this Section 2.02. 

ARTICLE 3: LEASE TERM 
 3.01. Lease
Term; Construction. The Initial Term of this Lease is set forth in Article 1. The Base Building and the Premises shall be constructed as provided in the Work Letter (the “Work Letter”) attached hereto as Exhibit C.

 3.02. Hold Over. If Tenant (or anyone claiming by, through or under Tenant) shall remain in occupancy of the Premises or any part
thereof after the expiration or early termination of the Term without a written agreement therefor executed and delivered by Landlord, then without limiting Landlord’s other rights and remedies the person remaining in possession shall be deemed
a tenant at sufferance, and Tenant shall thereafter pay a monthly use and occupancy charge (pro-rated for such portion of any partial month as Tenant (or anyone claiming by, through or under Tenant) shall
remain in possession) at a rate equal to the greater of (a) the Fair Market Rent for the Premises (which, notwithstanding anything to the contrary contained in this Lease, shall be deemed the rent then being quoted by Landlord for the Premises
(or any portion thereof) or comparable space in the Building, if the Premises (or any portion thereof) or any such space is then being marketed by Landlord), or (b) one hundred and fifty percent (150%) of the monthly amount payable as Base Rent
for the 12-month period immediately preceding such expiration or termination, and in either case with all Additional Rent also payable as provided in this Lease. No acceptance by Landlord of any payment by
Tenant pursuant to this Section shall constitute Tenant (or anyone claiming by, through or under Tenant) as a tenant at will, but Tenant or such other person or entity shall remain a tenant at sufferance subject to all of the provisions of this
Lease. If Landlord desires to regain possession of the Premises at any time Tenant (or anyone claiming by, through or under Tenant) is holding over, Landlord may, at its option, forthwith re-enter and take
possession of the Premises or any part thereof by any lawful, means. In any case, and notwithstanding the provisions of Section 16.10(b) to the contrary, Tenant shall be liable to Landlord for all claims, liabilities,
damages, losses or costs (including reasonable attorneys’ fees and costs) resulting from any failure by Tenant (or anyone claiming by, through or under Tenant) to vacate the Premises or any portion thereof when required hereunder, and shall
hold Landlord, its agents and employees, harmless and defend and indemnify Landlord, its agents and employees, from and against any and all claims, liabilities, damages, losses or costs (including reasonable attorneys’ fees and costs) which
Landlord may pay, incur or suffer on account of any such hold-over in the Premises after the expiration or earlier termination of the Term. 

  
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 3.03 Right to Extend. 

(a) Extension Term. Provided that, as of both the time Tenant gives the Extension Notice (as defined below) and the first day of the
Extension Term, (i) Tenant is not in default hereunder beyond all applicable notice and grace periods (if any), and (ii) the Tenant named in Article 1 above (or a Related Party Transferee) is then occupying at least seventy-five
percent (75%) of the Premises for the conduct of the Permitted Uses, then Tenant may extend the Term of this Lease for the Extension Term stated in Article 1 by giving unconditional written notice (an “Extension Notice”) to
Landlord at least twelve (12) months but not more than eighteen (18) months before the end of the Initial Term, time being of the essence. The Extension Notice shall be sufficient to extend the Term for the Extension Term, subject to all
of the terms of this Lease except for the change in Base Rent as set forth below, and no additional writing or further action by the parties shall be required for such purpose (but upon the request of either party, the parties shall promptly execute
and deliver an amendment to this Lease reflecting such extension of the Term). If Tenant fails to give the Extension Notice in strict accordance with the provisions of this Section 3.03(a), Tenant shall be deemed to have
waived all rights to extend the Term of this Lease. All references in this Lease to the “Term” shall mean the Initial Term as it may be extended by the Extension Term. 

(b) Extension Term Base Rent. Base Rent for the Extension Term(s) shall be the Fair Market Rent of the Premises (as defined below). Fair
market rent of the Premises (the “Fair Market Rent”) for the Extension Term shall be based upon leases or agreements to lease then being negotiated or executed with respect to comparable first-class office/laboratory space in the
Building or in comparable buildings in Watertown and other comparable inner suburban and suburban lab markets (excluding Kendall Square but including the Alewife section of Cambridge) with walkable urban amenities. In determining Fair Market Rent,
all relevant factors shall be taken into account, including size, location and condition of premises, lease term (including renewal options), tenant’s obligations with respect to operating expenses and taxes, tenant improvement allowances,
other inducements then being offered by landlords, condition of building, and services and amenities provided by the landlord. Fair Market Rent shall include provisions for increases or other adjustments during the Extension Term for which such
determination is being made. 
 (c) Determination of Fair Market Rent. Fair Market Rent shall be determined as follows: Landlord shall
give Tenant written notice (“Landlord’s Fair Market Rent Notice”) of Landlord’s determination of Fair Market Rent for the Extension Term within thirty (30) days of Tenant’s giving to Landlord the Tenant’s
Extension Notice. Tenant shall thereafter notify Landlord within thirty (30) days of Landlord’s giving to Tenant Landlord’s Fair Market Rent Notice of its agreement with or objection to Landlord’s determination of the Fair Market
Rent, whereupon in the case of Tenant’s objection, Fair Market Rent shall be determined by arbitration conducted in the manner set forth below. If Tenant does not notify Landlord within such 30-day period
of Tenant’s agreement with or objection to Landlord’s determination of the Fair Market Rent, then the Fair Market Rent for the Extension Term shall be deemed to be Landlord’s determination of the Fair Market Rent as set forth in
Landlord’s Fair Market Rent Notice to Tenant. If Tenant does notify Landlord within such 30-day period of Tenant’s objection to Landlord’s determination of the Fair Market Rent, then within ten
(10) days of Tenant’s giving such notice of objection to Landlord, each of Tenant and Landlord shall choose an MAI real estate appraiser or commercial real estate broker with at least ten (10) years of professional experience dealing
with properties similar to the Property in the vicinity of the Property (each a “Real Estate Professional”) and notify the other party of the person so selected. The Real Estate Professionals so selected shall each determine and
promptly report (in no event later than the thirtieth (30th) day following the giving of the notice of appointment of the second Real Estate Professional) to both Landlord and Tenant in writing
his or her determination of the Fair Market Rent. If the higher of the Fair Market Rents reported by the two Real Estate Professionals is no more than ten (10%) percent more than the lower rate, then the Fair Market Rent will be an average of such
amounts. However, if the higher amount is more than one hundred ten (110%) percent of the lower amount, then within ten (10) days after receipt of both reports, Landlord and Tenant will jointly appoint a third Real Estate Professional meeting
the aforesaid criteria, and the third Real Estate Professional will determine the Fair Market Rent by selecting either Landlord’s Fair Market Rent determination or Tenant’s Fair Market Rent determination according to whichever of the two
valuations as set forth in the reports from Landlord’s Real Estate Professional or Tenant’s Real Estate Professional, respectively, is closer to the actual Fair Market Rent in the opinion of such third Real Estate Professional. The third
Real Estate Professional shall have no discretion other than to select one of the determinations of Fair Market Rent made by the first two Real Estate Professionals as aforesaid. Landlord and Tenant shall each pay the Real Estate Professional that
it appoints, and shall share equally the cost of the third Real Estate Professional. 

  
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 (d) Rent Continuation. For any part of the Term for which the amount of Base Rent has
not finally been determined, Tenant shall make payment on account of Base Rent at the rate last paid under this Lease, and the parties shall adjust for any overpayments or underpayments upon the final determination of Fair Market Rent. The failure
by the parties to complete the processes contemplated under this Section 3.03 prior to the commencement of the Extension Term shall not affect the continuation of the Term or the parties’ obligation to make any
adjustments for any overpayments or underpayments for the Base Rent due for the applicable period promptly after the determination thereof is made. 

ARTICLE 4: RENT 
 4.01. Base Rent.
Commencing as of the Rent Commencement Date and continuing thereafter on the first day of each month during the Term, Tenant shall pay Landlord the monthly installment of Base Rent and the monthly installment of Tenant’s Pro Rata Share of
Operating Costs required by Section 4.02, in advance, without notice or demand. 
 4.02. Additional Rent

  

	 	(a)	 General. “Rent” means, collectively, Base Rent and all other amounts payable by Tenant
under this Lease other than Base Rent, including Tenant’s Pro Rata Share of Taxes (Article 5) and Operating Expenses (Article 7) , regardless of whether or not such amount is expressly described as “Additional Rent” in
this Lease (collectively, “Additional Rent”). Landlord shall reasonably estimate in advance (i) all Taxes under Article 5 and (ii) all Operating Expenses under Article 7 (the items in clauses (i) and
(ii), collectively, being “Operating Costs”) and Tenant shall pay one-twelfth (1/l2th) of Tenant’s Pro Rata Share of such reasonably
estimated Operating Costs monthly in advance together with Base Rent. Landlord may reasonably adjust its estimates of Operating Costs at any time based upon its experience and reasonable anticipation of costs. Such adjustments shall be effective as
of the next Rent payment date occurring at least fifteen (15) days after notice to Tenant. Within one hundred eighty (180) days after the end of each calendar year (or portion thereof) included within the Term, Landlord shall give Tenant a
reasonably detailed statement (an “Annual Operating Statement”) of the Operating Costs paid or incurred by Landlord during the preceding calendar year (pro-rated for partial calendar years
included within the Term) and Tenant’s Pro Rata Share of such expenses; provided, however, that Landlord may bill Tenant for any items omitted or underbilled with respect to the calendar year in question for a period of time not to
exceed one (1) year from the last day of such calendar year. Within thirty (30) days after Landlord’s delivery of an Annual Operating Statement to Tenant, Tenant shall pay Landlord any underpayment, or Landlord shall credit Tenant
with any overpayment (which credit shall be applied to any Rent due under this Lease next coming due after the delivery of the Annual Operating Statement (or if the Term has ended, Landlord shall pay Tenant the amount of any overpayment as provided
below)), of Tenant’s Pro Rata Share of such Operating Costs. 

 If Tenant wishes to dispute the determination of the
Operating Costs charged to Tenant under this Lease, Tenant may do so provided (i) Tenant shall give Landlord written notice of such dispute within one hundred twenty (120) days after its receipt of the Annual Operating Statement being
disputed and (ii) Tenant shall pay any overpayment due based on the Annual Operating Statement as provided in the foregoing paragraph, pending resolution of the dispute. If Landlord provides a revised Annual Operating Statement within the one-year period described in the preceding grammatical paragraph in response to a previously omitted or underbilled item of Operating Costs, Tenant shall have the same 120-day
period from its receipt of such revised Annual Operating Statement within which to give Landlord written notice that it disputes one or more of the revised items contained in such revised Annual Operating Statement (which shall be the only items
then subject to dispute by Tenant). Promptly after the giving of such notice in either such case, Landlord shall allow Tenant’s representatives to examine and audit in Landlord’s offices (or the office of its managing agent)
Landlord’s books and records with respect to the subject matter of the dispute, which review or audit shall be completed within ninety (90) days after Tenant gave such notice of dispute. Tenant agrees that the party selected by Tenant to
perform such review or audit shall be compensated on the basis of hourly fees and not on a contingency or percentage basis. Tenant agrees to keep the results of any such review or audit conducted by Tenant confidential except for disclosures to its
employees, attorneys, consultants, accountants and owners and except to the extent required to enforce Tenant’s rights hereunder. The cost of such audit shall be borne by Tenant; provided, however, in the event it is finally determined (by
mutual agreement or other resolution of such dispute) that Tenant was overcharged by more than five percent (5%) for the immediately preceding calendar year, then, in such event, Landlord shall pay for Tenant’s reasonable

  
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out-of-pocket cost for the audit. If it is finally determined (by mutual agreement or other resolution of such
dispute) that Landlord’s determination of any of the Operating Cost is (i) overstated, or (ii) understated, then in the case of (i) Landlord shall credit the difference against monthly installments of Rent next thereafter coming
due (or refund the difference if the Term has ended and Tenant has no further obligation to Landlord), or in the case of (ii) Tenant shall pay to Landlord the amount of such excess. Landlord’s obligation under this Paragraph shall survive
the expiration of the Term or earlier termination of this Lease. 
 If the Term expires or the Lease is terminated as of a date other than
the last day of a calendar year, Tenant’s payment of Additional Rent pursuant to this Section for such partial calendar year shall be based on Landlord’s good faith estimate of the items otherwise includable in Operating Costs and Landlord
shall provide such estimate to Tenant no later than thirty (30) days after the expiration or termination of the Term. Tenant’s payment of Additional Rent shall be made on or before ten (10) Business Days after Landlord delivers such
estimate to Tenant, with an appropriate payment or refund to be made upon Tenant’s later receipt of Landlord’s Annual Operating Statement for such calendar year. This Section shall survive the expiration or earlier termination of the Term.

 This Lease requires Tenant to pay directly to suppliers, vendors, carriers, contractors, and other parties certain utility costs,
personal property taxes, maintenance and repair costs and other expenses. If Tenant fails to make any such payments when due and Landlord thereafter receives notice of such failure on the part of Tenant, Landlord shall have the right (but no
obligation) to do so on its behalf, and if Landlord so pays any of these amounts in accordance with this Lease, Tenant shall reimburse such costs in full, together with interest thereon at the Default Rate, to Landlord, as Additional Rent, within
ten (10) Business Days of demand. 
 (b) Allocation of Certain Operating Costs. If at any time during the Term, Landlord provides
services (“Limited Landlord Services”) only with respect to particular portions of the Building or Property, or incurs any other Operating Costs allocable to particular portions of the Building or Property, then: (i) such
Operating Costs shall be charged entirely to those tenants, including Tenant, if applicable, of such portions, and the amounts so charged to such particular tenant or tenants shall be excluded from Operating Costs otherwise charged under
Section 4.06(A), and (ii) Tenant’s Pro Rata Share for any such Limited Landlord Services shall be as defined in Section 4.06(B). If, during any period for which Landlord’s Operating
Costs are being computed, less than ninety-five (95%) percent of the rentable area of the Building was leased and occupied by tenants: (x) Operating Costs that are allocable to the entire Building or the portion thereof in question and which
vary by level of occupancy shall be reasonably estimated and extrapolated by Landlord to determine the Operating Costs that would have been incurred if the Building or such portion in question were ninety-five (95%) leased and occupied by tenants
for such year and such services were being supplied to all tenants, and such estimated and extrapolated amount shall be deemed to be the Operating Costs for such period, and (y) Tenant’s Pro Rata Share with respect to such Operating Costs
shall be as defined in Section 4.06(A) or (B) as applicable; provided, however, that Landlord shall not collect from Tenant and other tenants in the Building in the aggregate more than one hundred percent of
Taxes and such Operating Costs actually incurred by Landlord. 
 4.03. Late Charge. Tenant acknowledges that if it pays Rent late,
Landlord will incur unanticipated costs which will be extremely difficult to ascertain exactly. Such costs include processing and accounting charges, and late charges that may be imposed on Landlord under a mortgage on the Property. Accordingly, if
Landlord does not receive any such payment within five (5) days following its due date, Tenant shall pay Landlord a late charge equal to five (5%) percent of the overdue amount as an administrative charge. The parties agree that this late
charge represents a fair and reasonable estimate of the costs Landlord shall incur by reason of Tenant’s payment default. Payment of the late charge shall not cure Tenant’s payment default or prevent Landlord from exercising any other
rights and remedies. 
 4.04. Interest. Any late Rent payment shall bear interest from the date due (without regard to the 5-day grace period provided in Section 4.03) until paid at a rate equal to the Prime Rate plus 4% per annum (the “Default Rate”), except to the extent such interest would
cause the total interest to be in excess of that legally permitted (and then interest will be at the maximum rate legally permitted). The “Prime Rate” shall mean the prime lending rate per annum published in The Wall Street
Journal from time to time, and the Default Rate shall be adjusted effective upon each change in the Prime Rate. 
 Payment of interest
shall not cure Tenant’s payment default or prevent Landlord from exercising any other rights and remedies. 
 4.05. Method of
Payment. Tenant shall make a pro rata payment of Base Rent and Additional Rent for any period of less than a month at the beginning or end of the Term. All payments of Base Rent, Additional Rent and other sums due shall be paid in current U.S.
exchange by check drawn on a Boston clearinghouse bank to the Original Address of Landlord or such other place as Landlord may from time to time direct (or if requested by Landlord in the case of Base Rent, by electronic fund transfer) without
demand (except to the extent notice or demand is expressly required herein), abatement (except to the extent expressly provided herein), set-off or other deduction. 

 

  
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 Without limiting the foregoing, except as expressly otherwise set forth in this Lease,
Tenant’s obligation so to pay Rent shall be absolute, unconditional, and independent and shall not be discharged or otherwise affected by any law or regulation now or hereafter applicable to the Premises, or any other restriction on
Tenant’s use, or any casualty or taking or any failure by Landlord to perform or other occurrence. 
 It is intended that Base Rent
payable hereunder shall be a net return to Landlord throughout the Term, free of expense, charge, offset, diminution or other deduction whatsoever on account of the Premises (excepting Landlord’s financing expenses, federal and state income
taxes of general application, and those expenses that this Lease expressly makes the responsibility of Landlord and excepting any expense or charge incurred as a result of Landlord’s acts or omissions), and all provisions hereof shall be
construed in terms of such intent. 
 4.06. Tenant’s Pro Rata Share. The term “Tenant’s Pro Rata Share”
shall have different definitions depending upon the circumstances in which such term is used. 
  

	 	(A)	 Entire Building. With respect to any Operating Costs and benefits that are allocable to the entire
Building and with respect to Tenant’s Parking Allotment, Tenant’s Pro Rata Share shall be defined as a fraction, the numerator of which is the total rentable area of the Premises, and the denominator of which is the total rentable area of
the Building, as of the date of the computation. As of the date hereof, the parties agree that the total rentable area of the Building is 185,015 square feet, and that Tenant’s Pro Rata Share is 24.62% (subject to adjustment as provided in
Section 2.0l(e) above. 

  

	 	(B)	 Costs that are only incurred for portions of the Building. With respect to any Operating Costs
and benefits that are allocable to only a portion of the Building which includes the Premises, Tenant’s Pro Rata Share shall be defined as a fraction, the numerator of which is the total rentable area of the Premises, and the denominator of
which is equal to the sum of the rentable square foot area of (i) the Premises and (ii) all other premises to which such cost is allocable. 

Tenant’s Pro Rata Share with respect to the entire Building is initially as set forth in Article 1 and Tenant’s Pro Rata
Share is subject to adjustment only if the total rentable area of the Premises changes on account of any amendment to the Lease as may be set forth in such amendment, or if the Building changes on account of any reconstruction after a casualty
event, expansion or contraction thereof. 
 ARTICLE 5: TAXES 

5.01. Taxes. Commencing as of the Rent Commencement Date and continuing thereafter throughout the Term of the Lease, Tenant covenants
and agrees to pay to Landlord as Additional Rent, Tenant’s Pro Rata Share of Taxes for each fiscal tax period, or ratable portion thereof, included in the Term. If Landlord receives a refund of any such Taxes, Landlord shall pay to Tenant
Tenant’s Pro Rata Share of the refund after deducting Landlord’s reasonable costs and expenses incurred in obtaining the refund, to the extent such costs and expenses were not previously included in, and actually paid as, Taxes pursuant to
Section 5.02 below. Tenant shall make estimated payments on account of Taxes in monthly installments on the first day of each month, in amounts estimated from time to time by Landlord pursuant to
Section 4.02(a). As of the Date of Lease, Landlord’s estimate of Taxes for the first Lease Year is $4.75 per rentable square foot of the Premises, but such amount is only an estimate and shall not govern over the
actual amount of Taxes for the first Lease Year as determined in accordance with the provisions of this Article. 
 5.02. Definition of
“Taxes”. “Taxes” shall mean all taxes, assessments, betterments, excises, user fees imposed by governmental authorities, and all other governmental charges and fees of any kind or nature, or impositions or agreed payments in
lieu thereof, or voluntary payments made in connection with the provision of governmental services or improvements of benefit to the Building or the Property (including any so-called linkage, impact or
voluntary betterment payments), assessed or imposed against the Premises, the Building or the Property (including any personal property taxes levied on such property or on 

  
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fixtures or equipment used in connection therewith). Furthermore, notwithstanding anything to the contrary herein, Taxes shall exclude (a) any interest and/or penalties for late payments to
the extent relating to a period in which Tenant was not in default (beyond any applicable notice and cure periods) of its obligations to pay Base Rent, Tenant’s Pro Rata Share of Operating Costs or other payments under this Lease, and
(b) federal, state or local income or profit taxes, franchise, rental, capital, inheritance, estate, conveyance, transfer, gift, or corporate excise taxes or levies. The amount of any special taxes, special assessments, and agreed or
governmentally imposed “in lieu of tax” or similar charges, shall be included in Taxes for any year but shall be limited to the amount of the installment (plus any interest, other than penalty interest, payable thereon) of such special
tax, special assessment or such charge required to be paid during or with respect to the year in question. Landlord agrees that if any special taxes, special assessments, and agreed or governmentally imposed “in lieu of tax” or similar
charges shall be levied against the Building, to elect to pay such assessment over the longest period of time permitted by law or applicable agreement with the governmental authority. Betterments and assessments, whether or not paid in installments,
shall be included in Taxes in any tax year as if the betterment or assessment were paid in installments over the longest period permitted by law, together with the interest thereon charged by the assessing authority for the payment of such
betterment or assessment in· installments. 
 Notwithstanding the foregoing, if during the Term the present system of ad valorem
taxation of property shall be changed so that, in lieu of or in addition to the whole or any part of such ad valorem tax there shall be assessed, levied or imposed on the Premises, the Building or the Property, or on Landlord, any kind or nature of
federal, state, county, municipal or other governmental capital levy, income, sales, franchise, excise or similar tax, assessment, charge or fee (as distinct from the federal and state income tax in effect on the Date of Lease) measured by or based
in whole or in part upon Building valuation, mortgage valuation, rents, services or any other incidents, benefits or measures of real property or real property operations, then any and all of such taxes, assessments, levies, charges and fees shall
be included within the term “Taxes”, but only to the extent that the same would be payable if the Property were the only property of Landlord. Taxes shall also include expenses, including reasonable fees of attorneys, appraisers and other
consultants, incurred in connection with any efforts to obtain abatements or reduction of Taxes for any year wholly or partially included in the Term, whether or not successful and whether or not such efforts involved filing of actual abatement
applications or initiation of formal proceedings. 
 5.03. Personal Property Taxes. Tenant shall pay directly all taxes (if any)
charged against Tenant’s Property (as defined in Section 10.06). Tenant shall use commercially reasonable efforts to have Tenant’s Property taxed separately from the Property. Landlord shall notify Tenant if any
of Tenant’s Property is taxed with the Property, and Tenant shall pay such taxes to Landlord within fifteen (15) days of such notice. 

ARTICLE 6: BUILDING SERVICES AND SPECIAL BUILDING FACILITIES 

6.01. Utility Services. 

(a) Tenant shall make all arrangements for, and shall provide and pay all charges and deposits required by the provider for, water, sewer, gas,
boiler water, electricity, telephone and any other utilities or services used or consumed on the Premises (collectively, “Utility Services”), whether called use charge, tax assessment, fee, or otherwise, as the same become due. As
part of the Base Building Work, Landlord will (i) install Oncom BTU metered taps for reheat hot water from the main Building loop to the Premises (if additional taps from the main loop are required, Tenant shall install them at its own cost and
expense, and any meters installed as part of such work shall be compatible with the Building equipment and the Building BMS system); (ii) provide space for a Tenant meter on the utility gas manifold so that Tenant can install (at its sole cost and
expense) any gas service necessary to service the exclusive needs of Tenant’s Premises; and (iii) provide a connection to the Building potable water service to the Premises (Tenant shall provide and install a water meter at this connection
with a remote reader to record Tenant’s use of domestic water within the Premises). Tenant shall install, as part of its electrical service switchgear, a CT cabinet with an electrical usage meter as required by the Utility Service Provider. If
the Utility Service Provider will not allow individual direct metering for Tenant’s service, this meter shall be used to measure Tenant’s direct usage of electricity within the Premises, (including the electricity consumed in providing
HVAC service to the Premises), for which Tenant shall reimburse Landlord at the direct billing rates charged to Landlord by the Utility Service Provider. Landlord shall bill Tenant monthly for such electrical consumption and hot water consumption as
a recurring charge, and Tenant shall pay each such invoice, as Additional Rent, within thirty (30) days after receipt of an invoice therefor. 

(b) Tenant shall timely pay all costs and expenses associated with any directly and separately metered utilities (such as telephone) provided
exclusively to the Premises directly to the applicable service provider. Tenant shall pay all costs and expenses associated with utility charges that are based on sub-metering or check metering directly to
Landlord, without mark-up by Landlord on account of Landlord’s administration of such charges, within thirty (30) days of invoice therefor by Landlord. With respect to any Utility Services that are
not either separately metered or measured by a check meter or submeter, Tenant shall pay the cost of the same 

  
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as part of Operating Costs payable hereunder. Tenant may, no more than once per calendar year, conduct an engineering survey at its sole cost and expense to determine whether the submeters and/or
check meters are accurately measuring the particular services to be measured thereby and, if Tenant discovers any metering inaccuracies as a result of such survey and such inaccuracies result in an error in the amount billed to Tenant, Landlord
shall promptly refund the overpayment within ten (10) Business Days after receipt of notice from Tenant of such inaccuracy. If requested by Landlord, Tenant and the persons conducting the engineering survey for Tenant shall enter into a
reasonable confidentiality agreement prior to inspecting such meters, which shall permit Tenant to disclose the results of such survey to the extent required to enforce its rights hereunder. If the survey shows any errors resulting in any
underpayment for such services, Tenant shall reimburse Landlord for Tenant’s share of such underpayment, as Additional Rent, within ten (10) Business Days of demand. In no event shall Tenant engage any person in connection with such
engineering survey whose fees or costs are payable, in whole or part or directly or indirectly, in a contingent manner or by means of any commission depending on the survey outcome. Any dispute regarding amounts due, or accuracy of the meters, under
this paragraph shall be resolved in accordance with Section 16.17 of this Lease at the request of Landlord or Tenant, which request shall be made with respect to disputes regarding amounts due, no later than one hundred
eighty (180) days after Tenant receives Landlord’s Annual Operating Statement for the fiscal year in question (any bill not disputed within such 180-day period shall be deemed final and conclusive).
Except as expressly set forth in Section 6.03, Landlord shall not be liable for any interruption or failure in the supply of any utilities or Utility Services. 

(c) To the maximum extent permitted by law, Landlord shall have the right at any time and from time to time during the Term to contract for or
purchase one or more Utility Services from any reputable company or third party providing Utility Services (“Utility Service Provider”) to the Building, provided that the rates charged by such Utility Service Provider are
competitive with the current market rates. In exercising its rights hereunder, Landlord shall make commercially reasonable efforts to avoid any interruption to Tenant’s business operations in connection with the change from one Utility Service
Provider to another. Subject to Section 9.06, Tenant agrees reasonably to cooperate with Landlord and such Utility Service Providers and at all times as reasonably necessary, and on reasonable advance notice of not less
than forty-eight (48) hours (except in the event of emergency), shall allow Landlord and the Utility Service Providers reasonable access to any utility lines, equipment, feeders, risers, ducts, shafts, fixtures, wiring and any other such
machinery or personal property within the Premises and associated with the delivery of Utility Services. 
 (d) Except for the Initial Tenant
Work and the equipment and appliances being installed in connection therewith, Tenant agrees that it will not make any material alteration or material addition to the electrical equipment and/or appliances in the Premises which would require
increased electrical service to the Premises or modifications to the structure of the Building, without the prior written consent of Landlord in each instance, which consent will not be unreasonably withheld, conditioned or delayed, and using
contractor(s) reasonably approved by Landlord, and will promptly advise Landlord of any other alteration or addition to such electrical equipment and/or appliances (as to which Landlord’s prior written consent shall not be required). Landlord
agrees to respond to any request for approval made by Tenant pursuant to this subsection (c) within ten (10) Business Days after its receipt of such request. 

6.02. Building Services and Building Systems. 

(a) In addition to the services described in Section 6.01, Landlord shall provide the following services to Building
common areas, the costs of which are included within Operating Expenses: 
  

	 	(i)	 Janitorial services for the Building common areas as described in Exhibit E attached hereto.

  

	 	(ii)	 Building security consistent with similar “first-class” laboratory and office buildings in the
vicinity of the Property as described in Exhibit E attached hereto. 

  

	 	(iii)	 Landlord shall arrange for and provide (as defined below) to the common areas of the Building those services as
set forth in Exhibit E attached hereto. 

  

	 	(iv)	 Landlord shall provide HVAC service to the common areas of the Building by means of the Building mechanical
system, during Normal Business Hours, at such temperatures and in such amounts as are reasonably deemed by Landlord to be in keeping with the first-class standards of the Building. 

Tenant acknowledges that Landlord has not made any warranty or representation to Tenant as to the efficacy of the security services that
Landlord is required to provide under this Lease. 

  
 14 

 (b) Landlord shall provide to the common areas of the Building the janitorial services as
described in Exhibit E attached hereto, the costs of which are included within Operating Expenses. Tenant shall, at its sole cost and expense, provide janitorial services to the Premises on each Business Day during the Term. In addition,
Tenant shall arrange for the removal and disposal of its lab-related refuse by a licensed vendor, all at Tenant’s sole cost and expense, such removal and disposal to be accomplished in accordance with all
applicable Legal Requirements. 
 (c) Tenant shall have the ability to control the provision of heat, ventilation or air conditioning to the
portions of the Premises served by the Building mechanical systems (as opposed to being provided by means of any HVAC equipment or system installed by or on behalf of Tenant and serving only the Premises). The electricity consumed in providing HVAC
service to the Premises through the Building mechanical system shall be measured by a submeter and charged back to Tenant by Landlord at Landlord’s actual cost, without mark-up. The hot water consumed in
providing HVAC service to the Premises through the Building mechanical system shall be metered to Tenant. Landlord shall bill Tenant monthly for such electrical consumption and hot water consumption as a recurring charge, and Tenant shall pay each
such invoice, as Additional Rent, within thirty (30) days after receipt of an invoice therefor. Tenant agrees to lower and close the blinds or drapes when necessary because of the sun’s position, whenever the air conditioning system is in
operation, and to cooperate fully with Landlord with regard to, and to abide by all the reasonable regulations and requirements which Landlord may prescribe for, the proper functioning and protection of the air conditioning system of general
applicability to all occupants of the Building and provided such regulations and requirements are provided in writing to Tenant thirty (30) days in advance. 

(d) If Tenant desires HVAC service to a common area of the Building outside of Normal Business Hours, Landlord will use reasonable efforts,
upon not less than twenty-four (24) hours’ prior written notice from Tenant of its requirements in that regard, to furnish additional heat or air conditioning services to such common area during such requested times. Tenant will pay to
Landlord Landlord’s actual hourly cost (including equipment depreciation), without markup, as the same may be adjusted from time to time by Landlord, for any such additional heat or air conditioning service required by Tenant. 

Excluding any equipment to be installed as part of the Initial Tenant Work, in the event Tenant requires additional air conditioning for
business machines, meeting rooms or other special purposes, or because of occupancy or excess electrical loads, any additional air conditioning units, chillers, condensers, compressors, ducts, piping and other equipment, such additional air
conditioning equipment will be installed, but only if, in Landlord’s reasonable judgment, the same will not cause damage or injury to the Building or create a dangerous or hazardous condition. At Landlord’s sole election, such equipment
will either be installed: 
  

	 	(i)	 by Landlord at Tenant’s expense and Tenant shall reimburse Landlord within thirty (30) days of demand
(to the extent that such equipment will serve portions of the Property other than the Premises, Tenant shall only be obligated to pay its proportionate share of such cost), as Additional Rent, in such an amount as will compensate it for the cost
incurred by it in operating, maintaining, repairing and replacing, if necessary, such additional air conditioning equipment. At Landlord’s election, such equipment shall be maintained, repaired and replaced by Tenant at Tenant’s sole cost
and expense, and throughout the term of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase and maintain a service contract for such equipment from a service provider reasonably approved by Landlord (to the extent that such
equipment will serve portions of the Property other than the Premises, Tenant shall only be obligated to pay its proportionate share of such costs). Tenant shall obtain Landlord’s prior written approval of both the form of service contract and
of the service provider, which approval shall not be unreasonably withheld, conditioned or delayed; or 

  

	 	(ii)	 only if the additional equipment will exclusively serve the Premises, by Tenant, subject to Landlord’s
prior reasonable approval of Tenant’s plans and specifications for such work. In such event: (i) such equipment shall be maintained, repaired and replaced by Tenant at Tenant’s sole cost and expense, and (ii) throughout the term
of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase and maintain a service contract for such equipment from a service provider approved by Landlord. Tenant shall obtain Landlord’s prior written approval of both the
form of service contract and of the service provider, which approval shall not be unreasonably withheld, conditioned or delayed. 

  
 15 

 (e) Pursuant to Section 10.03, Landlord shall repair, maintain in
good condition and order, and replace all Building Systems (including the HVAC, plumbing, electrical, mechanical and other systems) to the extent to which the same were installed as part of the Base Building Work, subject to casualty, condemnation
and matters described in Section 16.09, the cost of which shall be included in Operating Expenses to the extent provided in Section 7.01. Tenant shall be solely responsible, at its sole cost and expense, for
repairing, maintaining and replacing all equipment which services solely the Premises, whether the same were initially installed by Landlord or Tenant, and whether the same were installed prior to the Rent Commencement Date or thereafter, except to
the extent the need for such repair results from Landlord’s negligence or willful misconduct or the negligence or willful misconduct of its agents, employees, contractors, and/or invitees. In no event shall Landlord be liable for any
interruption or delay in providing any of the services described in this Section or in Exhibit E attached hereto by reason of any accident, the making of repairs, alterations or improvements, labor difficulties, trouble in obtaining fuel,
electricity, service or supplies from the sources from which they are usually obtained for such Building, governmental restraints, or any cause beyond Landlord’s control. 

(f) Notwithstanding anything to the contrary contained in this Article 6 or elsewhere in this Lease, Landlord may institute, and Tenant
shall comply with, such policies, programs and measures as may reasonably be necessary, required, or expedient for the conservation and/or preservation of energy or energy services, or as may be necessary or required to comply with applicable Legal
Requirements, provided the same do not materially interfere with Tenant’s use of the Premises or Tenant’s business or cause the Tenant to incur additional costs. 

(g) Tenant acknowledges that it has been provided with an opportunity to confirm that the electric current serving the Premises will be
adequate to supply its proposed permitted uses of the Premises. If, however, Tenant subsequently determines that it will require electric current for use in the Premises in excess of the quantity which, in Landlord’s reasonable judgment,
Landlord’s facilities are capable of providing, then Landlord, upon written request and at the sole cost and expense of Tenant, will furnish and install such additional wire, conduits, feeders, switchboards and appurtenances as reasonably may
be required to supply such additional requirements of Tenant if current therefor be available to Landlord, provided that the same shall be permitted by applicable Legal Requirements and Insurance Requirements, and shall not cause damage to the
Building or the Premises or cause or create a dangerous or hazardous condition or entail excessive or unreasonable alterations or repairs. 

(h) Tenant shall have the right to install, at its sole cost and expense, a security system for its Premises provided that (i) such
security system is compatible with any security system installed by Landlord with respect to the Building as a whole, and (ii) Tenant shall provide Landlord with access cards, keys or codes as required to gain entry into all parts of the
Premises, subject to the provisions of Section 9.06. On or prior to the date hereof, Landlord shall provide Tenant with schematics and plans with the location of cameras and all security access points in and around the
Premises. 
 (i) For the Term of this Lease, Landlord shall contract for the provision of scheduled shuttle private bus service or other
vehicular transportation for employees of Tenant and other tenants at the Property to and from the Property and the Harvard Square MBTA Red Line Station, as more particularly provided in Exhibit F attached hereto. 

(j) Landlord shall, at its sole cost and expense, construct a loading area and install a freight elevator, all as more particularly provided in
the Work Letter attached hereto as Exhibit C, at the location identified on Exhibit A attached hereto or as otherwise agreed upon by the parties. Tenant shall have the right to use such loading dock and freight elevator, in common with
other tenants of the Building, on a 24/7 basis at no additional charge. 
 6.03. Service Interruptions. When necessary by reason of
accident or emergency, or for repairs, alterations, replacements or improvements which in the reasonable judgment of Landlord are desirable or necessary to be made, or by reason of event(s) of Force Majeure, Landlord reserves the right to interrupt,
curtail, stop or suspend (i) the furnishing of heating, elevator, air conditioning, and cleaning services and (ii) the operation of the plumbing and electric systems. Landlord shall exercise reasonable diligence to eliminate the cause of
any such interruption, curtailment, stoppage or suspension, but there shall be no diminution or abatement of rent or other compensation due from Landlord to Tenant hereunder, nor shall this Lease be affected or any of the Tenant’s obligations
hereunder reduced, and the Landlord shall have no responsibility or liability for any such interruption, curtailment, stoppage, or suspension of services or systems, except as provided herein. Landlord shall schedule all non-emergency interruptions, curtailments, stops or suspensions of services or systems in advance after consultation with Tenant, and shall make commercially reasonable efforts to avoid the same interfering with
Tenant’s business. 

  
 16 

 Notwithstanding the foregoing, Tenant shall be entitled to a proportionate abatement of Base
Rent in the event of a Landlord Service Interruption (as defined below). For the purposes hereof, a “Landlord Service Interruption” shall occur in the event (i) the Premises shall lack any service which Landlord is required to provide
hereunder thereby rendering at least fifty (50%) percent of the usable area of the Premises untenantable for the entirety of the Landlord Service Interruption Cure Period (as defined below), (ii) such lack of service was not caused by the act or
omission of Tenant or any Tenant Party; (iii) Tenant in fact ceases to use at least fifty (50%) percent of the Premises for the entirety of the Landlord Service Interruption Cure Period; and (iii) such interruption of service was the
result of causes, events or circumstances within the Landlord’s reasonable control and the cure of such interruption is within Landlord’s reasonable control. During such Landlord Service Interruption Period, Landlord will, if reasonably
practical, cooperate with Tenant to arrange for the provision of any interrupted services on an interim basis via temporary measures until final corrective measures can be accomplished and Tenant will permit Landlord the necessary access to the
Premises to remedy such lack of service, subject to the provisions of Section 9.06. For the purposes hereof, the “Landlord Service Interruption Cure Period” shall be defined as seven (7) consecutive Business
Days after Landlord’s receipt of written notice from Tenant of the Landlord Service Interruption. This Section 6.03 shall be Tenant’s sole and exclusive remedy on account of an interruption of services or Landlord
default resulting in an interruption of services other than Tenant’s right to obtain affirmative injunctive relief. This Section 6.03 shall not apply to any interruption or failure of services required to be provided
by Landlord under Section 6.02(a) or Exhibit E attached hereto, which is caused in whole or in part by any act or omission of Tenant or any Tenant Party, or by any occurrence described in
Section 16.09, or by any cause whatsoever other than those set forth in the first sentence of this Section 6.03. Notwithstanding the foregoing, if either Landlord or Tenant disputes in good faith
whether, or the extent to which, an event is subject to the provisions of this Section 6.03, or the amount of Tenant’s abatement of Base Rent hereunder, such dispute shall be resolved in accordance with
Section 16.17 of this Lease; provided, however, that in the event that it is ultimately determined that there was a Landlord Service Interruption, then Tenant shall have the right to a retroactive equitable abatement of
Base Rent for the period as set forth above, provided that, if the Term expires before Tenant’s entire retroactive abatement has been effected, then Landlord shall immediately refund to Tenant any overpayment of Rent due under the Lease not yet
received on account of the retroactive abatement. 
 ARTICLE 7: OPERATING EXPENSES 

7.01. Operating Expenses. 

(a) “Operating Expenses” shall mean all costs and expenses of whatever nature associated with the ownership, operation,
management, cleaning, maintenance or repair of the Property, and of all Building Systems. Operating Expenses include the costs and expenses incurred in connection with the following (subject to the limitations and exclusions set forth in this
Section 7.01): compliance with Landlord’s obligations under Sections 6.01. 6.02 and 10.03; planting and landscaping; snow removal; utility, water and sewage services (in each case to the extent not metered to
and payable by specific tenants of the Building); maintenance of signs; supplies, materials and equipment purchased or rented; total wage and salary costs paid to, and all contract payments made on account of, all persons engaged in the management,
operation, maintenance, security, cleaning and repair of the Property, including Social Security, old age and unemployment taxes and so-called “fringe benefits”; services generally furnished to
tenants of the Property; maintenance, repair and replacement of Building equipment and components; utilities consumed and expenses incurred in the operation, maintenance and repair of the Property; costs incurred by Landlord in the performance of
its obligations under the Agreements; costs incurred by Landlord to comply with the terms and conditions of any governmental approvals affecting operations of the Property; workers’ compensation insurance and property, liability and other
insurance premiums; personal property taxes; rental or lease payments paid by Landlord for rented or leased personal property used in the operation or maintenance of the Property (provided that any such payments made to Affiliates of Landlord shall
not exceed the amount otherwise payable in an arm’s length transaction); rental or license payments paid by Landlord for parking areas to be made available for use by tenants of the Property; fees for required licenses and permits; routine
maintenance and repair of Parking Facilities (whether situated on or off of the Property) and paving, including sweeping, striping, repairing, repaving and resurfacing; refuse removal; security; shuttle and other transportation services operated or
contracted for by Landlord to provide transportation for employees of tenants of the Property between the Property and mass transit locations (which shuttle may service other locations owned or controlled by Landlord, in which case Landlord shall
equitably allocate the costs of such shuttle between the various properties); and property management fees (provided, however, that for purposes of calculating Operating Expenses under this Lease, no property management fee in excess of two
(2%) percent of Base Rent shall be included). Landlord may use third parties or Affiliates to perform any of these services, and the cost thereof shall be included in Operating Expenses, so long as such third parties are professional and such costs
are comparable to market rate costs. Costs referred to in this Section shall be ascertained in accordance with generally accepted accounting principles and allocated to appropriate fiscal periods on the accrual method of accounting. As of the Date
of Lease, Landlord’s estimate of Operating Expenses for the first Lease Year is $5.52 per rentable square foot of the Premises, but such amount is only an estimate and shall not govern over the actual amount of Operating Expenses for the first
Lease Year as determined in accordance with the provisions of this Article. 

  
 17 

 (b) Operating Expenses shall only include capital expenditures that (A) are for the
primary purpose of reducing Operating Expenses (and then only to the extent that the amount of any annual amortization amount otherwise calculated pursuant to this subsection (b) does not exceed the amount of such savings on an annual basis, as
reasonably determined by Landlord), or (B) are required by changes in Legal Requirements or Insurance Requirements occurring after the Delivery Date. Any capital expenditures not excluded from Operating Expenses pursuant to this paragraph shall
be amortized over the useful life of the item in question as reasonably determined by Landlord in accordance with the relevant provisions of the Internal Revenue Code and the regulations promulgated thereunder, as amended from time to time, together
with interest at Landlord’s actual interest rate incurred in financing such capital expenditures, or, if no part of such expenditure is financed, at an imputed interest rate equal to the Prime Rate plus 2%. 

(c) Notwithstanding anything contained herein to the contrary, in no event shall Operating Expenses include any of the following: 

 

	 	(1)	 expenses incurred by Landlord to lease space to new tenants or to retain existing tenants including marketing
costs, brokerage commissions and concessions and leasehold improvement costs, finders’ fees, attorneys’ fees and expenses, entertainment costs and travel expenses; 

 

	 	(2)	 debt service; 

  

	 	(3)	 attorneys’ fees incurred in connection with lease negotiations or disputes with individual tenants, and
other expenses and attorneys’ fees to resolve disputes, enforce or negotiate lease terms with prospective or existing tenants or in connection with any financing, sale or syndication of the Property; 

 

	 	(4)	 accountants’ fees incurred in connection with disputes with individual tenants and/or the existence,
maintenance or non-Property related operations of the legal entity or entities of which Landlord is comprised. Without limitation, the foregoing shall not exclude the costs of preparing financial statements
for Operating Expenses; 

  

	 	(5)	 the cost of any special work or service performed for any tenant (including Tenant) or licensee, such as
after-hours HVAC service, which is billable to such tenant or licensee, or any costs in connection with services or benefits that are provided to or for the particular benefit of specific (but less than all of) the tenants and billable to them, and
expenses for any item or service not provided to Tenant but to certain other tenant(s) in the Building; 

  

	 	(6)	 the cost of any items for which Landlord is reimbursed by insurance, condemnation, licensees, tenants (other
than through general operating expense provisions) or otherwise; 

  

	 	(7)	 the cost of any additions, changes, replacements, painting, decorating, renovations and other items that are
made solely in order to prepare tenant space for a new tenant’s occupancy, or the cost of any other work in any space leased to an existing or prospective tenant or other occupant of the Building or the Property; 

 

	 	(8)	 interest, principal, points and fees, amortization or other costs and expenses associated with any debt or
amortization payments on any mortgage or deed to secure debt and rental under any ground lease, master space lease or other underlying lease; 

  

	 	(9)	 any expenses for repairs or maintenance to the extent reimbursed due to warranties and service contracts;

  

	 	(10)	 any cost that Tenant pays for directly (either to Landlord or a third party); 

 

	 	(11)	 any cost for which Landlord is reimbursed by a warranty that Landlord is required to obtain in connection with
the Property pursuant to this Lease or that Landlord otherwise obtains in connection with the Property; 

  

	 	(12)	 any amounts paid to an Affiliate of Landlord for the performance of services that is in excess of the amount
that would have been paid on an arm’s length basis in the absence of such relationship; 

  

	 	(13)	 depreciation and amortization of the Property or any part thereof (except as otherwise provided in
Section 7.01(b) above); 

  

	 	(14)	 salaries and bonuses and benefits of officers, executives of Landlord and administrative employees above the
grade of property manager or building supervisor, and if a property manager or building supervisor or any personnel below such grades are shared with other buildings or has other duties not related to the building containing the Premises, only the
allocable portion of such person’s or persons’ salary, bonuses, and benefits shall be included in Operating Expenses; 

  
 18 

	 	(15)	 Landlord’s general overhead and administrative expenses; 

 

	 	(16)	 any capital expenditures, except to the extent expressly permitted pursuant to this
Section 7.01; 

  

	 	(17)	 expenses incurred by Landlord to the extent the same are chargeable to any other tenant or occupant of the
Property, or to any third party; 

  

	 	(18)	 management fees in excess of two percent (2%) of Base Rent; 

 

	 	(19)	 any cost incurred by the negligence or willful misconduct of Landlord, its agents and employees;

  

	 	(20)	 penalties, fines and other costs incurred due to violation by Landlord of any lease or any Legal Requirements
applicable to the Building, and any interest or penalties due for late payment by Landlord of any of the Operating Expenses; 

  

	 	(21)	 Taxes; 

  

	 	(22)	 reserves; 

  

	 	(23)	 cost of alterations, capital improvements, equipment replacement and other items which under generally accepted
accounting principles are properly classified as capital expenditures except as provided in Section 7.01(b); 

  

	 	(24)	 payments for rented equipment, the cost of which equipment would constitute a capital expenditure of the
equipment were purchased; 

  

	 	(25)	 costs and expenses incurred by Landlord in connection with the repair of damage to the Building or Property
caused by fire or other casualty, insured or required to be insured against hereunder, other than the deductible amount under such insurance policies; 

  

	 	(26)	 the cost of correcting defects in the initial construction of the Building; 

 

	 	(27)	 the cost of any item for which Landlord is reimbursed through condemnation awards; 

 

	 	(28)	 insurance premiums to the extent any unusual tenant activity causes Landlord’s existing insurance premiums
to increase or requires Landlord to purchase additional insurance, but only to the extent such additional cost can be identified by the insurer and are not passed through by Landlord to a specific tenant; 

 

	 	(29)	 the costs of all purchases of supplies for the Building or Property which create a larger than 90-day inventory; 

  

	 	(30)	 intentionally deleted; 

 

	 	(31)	 costs and expenses of investigating, monitoring and remediating hazardous materials which were present on or
beneath the surface of the Property as of the Date of Lease; and 

  

	 	(32)	 intentionally deleted. 

Tenant shall pay Tenant’s Pro Rata Share of Operating Expenses in accordance with Section 4.02. 

  
 19 

 ARTICLE 8: INSURANCE 

8.01. Coverage. Tenant shall maintain throughout the Term, at its sole cost and expense, insurance for the benefit of Tenant and
Landlord (as their interests may appear) from insurers licensed to do business in the state in which the Property is located, rated at least “A:IX” by A.M. Best, with terms and coverages reasonably satisfactory to Landlord, and with such
increases in limits as Landlord may from time to time require (provided that such limits are the same as those then being provided by similar types of tenants in the greater Boston area under leases of similar types of premises). Initially, Tenant
shall maintain the following on an occurrence basis (except as otherwise expressly provided below): 
  

	 	(A)	 Commercial general liability insurance on an occurrence basis naming Landlord, Landlord’s managing agent
and Landlord’s mortgagee(s) of which Tenant has received prior written notice from time to time as additional insureds, insuring against all claims and demands for personal injury liability (including bodily injury, sickness, disease, and
death) or damage to property, with combined single limits of not less than $5,000,000 per occurrence and $5,000,000 in the aggregate, which coverages may be effected by primary or excess coverage. The policy shall not contain any intra-insured
exclusions as between insured persons or organizations, but shall include coverage for liability assumed under this Lease as an “insured contract” for the performance of Tenant’s indemnity obligations under this Lease. Such insurance
shall be primary and not contributing to any insurance available to Landlord, and Landlord’s insurance (if any) shall be in excess thereto; 

  

	 	(B)	 Property insurance covering property damage and business interruption. Covered property shall include
all Tenant improvements in the Premises other than the Initial Tenant Work, but including all other Tenant Work, and Tenant’s Property. Such insurance, with respect only to Tenant Work, shall name Landlord and Landlord’s mortgagees of
which Tenant has received written notice from time to time as additional loss payees as their interests may appear. Such insurance shall be written on an “all risk” of physical loss or damage basis including the perils of fire, extended
coverage, windstorm, vandalism, malicious mischief, sprinkler leakage, and such other risks Landlord may from time to time designate (provided that insurance for such risks is then commercially available at commercially reasonable rates and is being
carried by similar tenants for research and laboratory facilities in the vicinity of the Property), for the full replacement cost of the covered items and in amounts that meet any co-insurance clause of the
policies of insurance, with a deductible amount not to exceed a then-commercially reasonable deductible, which initially shall be no greater than $50,000; 

  

	 	(C)	 Workers’ compensation insurance with statutory benefits and employers liability insurance in the following
amounts: each accident, $1,000,000; disease (policy limit), $1,000,000; disease (each employee), $1,000,000; 

  

	 	(D)	 Pollution legal liability insurance covering first and third party claims for
clean-up costs, personal injury and property damage on an on-site and off-site basis, with a single claim and aggregate claim
amount of Three Million Dollars ($3,000,000.00), naming Landlord, Landlord’s managing agent and Landlord’s mortgagee(s) from time to time as additional insureds. The parties acknowledge and agree that the insurance required by this
paragraph (D) shall not include coverage for pre-existing environmental conditions at the Property as of the Date of Lease; and 

 

	 	(E)	 During all construction by Tenant, Tenant shall maintain with respect to the Premises and Property adequate
builder’s risk insurance, in form and amount reasonably satisfactory to Landlord based upon the scope of work, (and Landlord, its mortgagees of which Tenant has received written notice, and any ground or master lease lessors of which Tenant has
received written notice shall be named as an additional insured party as their interest may appear). 

 Tenant shall give
Landlord certificate(s) evidencing (i) the coverages required by Sections 8.1(A), (B) and (C) on or before the Date of Lease, which coverages shall be effective as of such date, (ii) the coverage required by
Section 8.1(D) not later than thirty (30) days prior to the earlier of either (x) the first delivery of Hazardous Materials to the Property for Tenant’s use or (y) Tenant’s occupancy of any portion
of the Premises for the conduct of business therein, which coverage shall be effective not later than the earlier of the dates set forth in the foregoing clauses (x) and (y), and (iii) the coverage required by
Section 8.1(E) not later than thirty (30) days prior to the date on which Tenant anticipates that Tenant’s Contractor will commence its on-site mobilization for the
performance of the Initial Tenant Work, which coverage shall be effective not later than the date on which Tenant’s Contractor actually commences such on-site mobilization. Thereafter, Tenant shall
provide 

  
 20 

 
certificates of each insurance coverage required by this Section not less than thirty (30) days before the expiration of such insurance coverage. All insurance certificates required to be
provided by Tenant shall state that such coverages may not be canceled or amended so as to materially adversely affect Landlord’s interest without at least ten (10) days’ prior written notice to Landlord and Tenant for cancellation
due to non-payment and thirty (30) days’ prior written notice to Landlord and Tenant for other cancellations or amendments. All deductible amounts or self-insured retentions shall be subject to
Landlord’s prior written approval (which shall not be unreasonably withheld, conditioned or delayed), and shall be the sole responsibility of Tenant. In addition, Tenant shall cause Tenant’s Contractor to provide to Tenant on or before the
Date of Lease certificates evidencing the coverages required by Sections 8.1(A), (B) and (C) maintained by Tenant’s Contractor, and naming as additional insureds Landlord, Landlord’s managing agent and Landlord’s
mortgagee(s) of which Tenant has received prior written notice from time to time, which coverages shall be effective as of such date, and thereafter to provide to Landlord certificates of each such insurance coverage not less than thirty
(30) days before the expiration of such insurance coverage. 
 If Tenant does not procure the insurance required pursuant to this
Section, or keep the same in full force and effect, Landlord may, but shall not be obligated to, take out the necessary insurance and pay the premium therefor after notice thereof to Tenant, and Tenant shall repay to Landlord, as Additional Rent,
the amount so paid (together with interest thereon at the Default Rate) within ten (10) days of demand. In addition, Landlord may recover from Tenant, as Additional Rent, any and all reasonable expenses (including reasonable attorneys’
fees) and damages which Landlord may sustain by reason of the failure by Tenant to obtain and maintain such insurance, it being expressly declared that the expenses and damages of Landlord shall not be limited to the amount of the premiums thereon.
The foregoing rights and remedies of Landlord shall not be deemed to waive any default or Event of Default under this Lease resulting from any such failure by Tenant to procure or to maintain in full force and effect any insurance required by this
Section. 
 8.02 Avoid Action Increasing Rates. Tenant shall not use or permit any use of the Premises beyond the Permitted Use that
in any way that will make voidable any insurance on the Property, or on the contents of the Property, or which shall be contrary to any requirements from time to time established or made by Landlord’s insurer, or which increases the cost of
Landlord’s insurance or requires additional insurance. Tenant shall cure any breach of this Section within ten (10) days after notice from Landlord or Tenant otherwise learning of such by (i) stopping any use that jeopardizes any
insurance coverage or increases its cost or (ii) paying the increased cost of insurance. Tenant shall have no further notice or cure right under Article 13 for any such breach. Tenant shall reimburse Landlord within ten (10) days of
demand, as Additional Rent, for all of Landlord’s costs reasonably incurred in providing any insurance that is attributable to any special endorsement or increase in premium resulting from the business or operations of Tenant other than those
customarily associated with laboratory use for the type of medical research conducted by Tenant, and any special or extraordinary risks or hazards resulting therefrom, including any risks or hazards associated with the generation, storage and
disposal of Hazardous Materials. 
 8.03. Waiver of Subrogation. Landlord and Tenant each waive any and every claim for recovery from
the other for any and all loss of or damage to the Property or any part of it, or to any of its contents, which loss or damage is covered by valid and collectible property insurance (or which would have been covered had the insurance policies
required to be maintained by Tenant or Landlord under this Lease been in force, to the extent that such loss or damage would have been recoverable under such policies). This mutual waiver precludes the assignment of any such claim by subrogation (or
otherwise) to an insurance company (or any other person), and Landlord and Tenant each agree to give written notice of this waiver to each insurance company that has issued or shall issue any property insurance policy to it, and to have such
policies properly endorsed, if necessary, to prevent invalidation of the insurance coverage because of this waiver. In consideration of the foregoing, each of the parties hereto agrees with the other party that such insurance policies as it may have
in effect during the Term of this Lease shall include a clause or endorsement which provides in substance that the insurance company waives any right of subrogation which it might otherwise have against Landlord, Landlord’s managing agent, or
Tenant. 
 8.04. Landlord’s Insurance. Landlord may, in its sole and absolute discretion, but shall not be obligated to, purchase
and maintain during the Term with insurance companies qualified to do business in the state where the Property is located, such insurance as Landlord deems appropriate, which insurance may include the following: (i) commercial general liability
insurance for incidents occurring in the common areas, with coverage for premises/operations, personal and advertising injury, products/completed operations and contractual liability for bodily injury and property damage, with limits and deductibles
as determined by Landlord, and (ii) property insurance covering property damage to the Building, including the Initial Tenant Work but excluding any other Tenant Work. Throughout the Term, Landlord shall maintain, with responsible companies
qualified to do business in the Commonwealth of Massachusetts, insurance on the Building covering the same against fire and other casualty covered in an “all-risk” policy, at its full replacement
cost. As set forth in Section 4.02, the cost of any such insurance shall be borne by Tenant and other tenants as part of Operating Costs. 

  
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 ARTICLE 9: USE OF PREMISES 

9.01. Permitted Uses. Tenant shall use the Premises only for the Permitted Uses described in Article 1 and
for no other use. Tenant shall keep the Premises equipped with appropriate safety appliances to the extent required by applicable Legal Requirements or Insurance Requirements. Tenant shall not cause or permit any potentially harmful air emissions,
or other objectionable odors or emissions exceeding those typically emitted from normal laboratory operations similar to those conducted by Tenant, to emanate from or permeate the Premises. Tenant shall not conduct or permit any auctions or
sheriff’s sales at the Property. 
 9.02. Indemnification. Tenant is responsible for the Premises and any Tenant’s
improvements, equipment, facilities and installations, wherever located on the Property and all liabilities, including tort liabilities, incident thereto, except to the extent caused by the negligence or willful misconduct of Landlord,
Landlord’s agents, employees, contractors or invitees, or the Indemnitees. Except to the extent caused by the negligence or willful misconduct of Landlord, Landlord’s agents, employees, contractors or invitees, or the Indemnitees, Tenant
shall indemnify, save harmless and defend Landlord and Landlord’s partners, shareholders, members, managers, owners, officers, mortgagees, ground lessors, agents, employees, independent contractors, Landlord’s managing agent and other
persons acting under them (collectively, “indemnitees”) from and against all liability, claim, damage, loss or cost (including reasonable attorneys’ fees) to the extent arising from (i) any alleged or actual injury, loss,
theft or damage to any person or property while on the Premises; (ii) any alleged or actual injury, loss, theft or damage to any person or property while on the Property or in the Building (other than within the Premises) to the extent arising
from the acts or omissions of Tenant or persons claiming by, through or under Tenant, or any of their respective officers, employees, agents, servants, contractors or invitees (collectively, “Tenant Parties”); (iii) failure of
Tenant or any Tenant Party to comply with any provision of this Lease; or (iv) the use of the Premises, the Property or the Building by Tenant or any Tenant Party, in each case under (i) through (iv) above paying any cost to Landlord on
demand as Additional Rent. 
 Except to the extent caused by the negligence or willful misconduct of Tenant or Tenant Parties, Landlord
shall indemnify, save harmless and defend Tenant and Tenant Parties from and against all liability, claim, damage, loss or cost (including reasonable attorneys’ fees) to the extent arising from (i) the negligence or willful misconduct of
Landlord, Landlord’s agents, employees, contractors or invitees, or the Landlord Indemnitees, or (ii) the failure of Landlord, Landlord’s agents, employees, contractors or invitees, or the Indemnitees, to comply with any provision of
this Lease. 
 The provisions of this Section shall survive the expiration or earlier termination of this Lease. 

9.03. Compliance With Legal Requirements. 

(a) Tenant shall not permit the Premises, or cause the Premises or the Property or the Building, to be used in any way that violates any
applicable law, code, ordinance, restrictive covenant or other encumbrance of record, governmental regulation, order, permit, approval or any other governmental consent (each a “Legal Requirement”), or that unreasonably interferes
with the use of other portions (i.e., other than the Premises) of the Property by other tenants of the Property, or constitutes a nuisance or waste. Tenant shall, at its sole cost and expense, be responsible for material compliance with all Legal
Requirements applicable to the Premises (or to the Property by reason of Tenant’s use and occupancy of the Premises) or to Tenant’s use thereof. The foregoing notwithstanding, Landlord, and not Tenant, shall be responsible for making all
improvements and alterations to the common areas of the Building which are required to cause the same to comply with all present and future Legal Requirements (the cost of which shall be included in Operating Expenses pursuant to
Section 7.01(b). Furthermore, Tenant shall not be responsible for any violation of a Legal Requirement or Environmental Law (i) that occurred prior to the Delivery Date, (ii) that occurred in connection with the
Base Building Work or (iii) to the extent that such violation was caused by the negligence or willful misconduct of Landlord or Landlord’s agents, employees, contractors or invitees. 

(b) Tenant shall be responsible, at its sole cost and expense, for procuring and maintaining in full force and effect, and complying at all
times with, any and all necessary permits, certifications, permissions and the like and complying with any reporting requirements directly relating or incident to the conduct of its activities on the Premises. Within ten (10) Business Days of a
request by Landlord, which request shall be made not more than once during each period of twelve (12) consecutive months during the Term hereof, unless otherwise requested by any mortgagee of Landlord or prospective purchaser of the

  
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Property, Tenant shall furnish Landlord with copies of all such permits that Tenant has obtained together with a certificate certifying that Tenant is in material compliance with all Legal
Requirements and Environmental Laws applicable to its use and occupancy of the Premises, or, if applicable, identifying any violations of which Tenant is aware and which are Tenant’s obligation to cure under the terms hereof, and setting forth
the steps which Tenant is taking to cure such violations. Tenant shall promptly give notice to Landlord of any written warnings or violations resulting from Tenant’s use or occupancy of, or any condition within, the Premises (including building
code violations, fire safety code violations, wastewater management violations, OSHA violations, or violations of Legal Requirements (including Environmental Laws)) received from any federal, state, or municipal agency or any court of law within ten
(10) Business Days after Tenant’s receipt of such notice and, to the extent that the cure of such violation is Tenant’s obligation hereunder, shall promptly cure the conditions causing any such violations. Tenant shall not be deemed
to be in default of its obligations under the preceding sentence to promptly cure any condition causing any such violation in the event that, in lieu of such cure, Tenant shall contest the validity of such violation, or apply for a variance or
permission to allow such use by appellate or other proceedings permitted under applicable Legal Requirements, provided that: (i) any such contest is made reasonably and in good faith, (ii) Tenant makes provisions reasonably acceptable to
Landlord, including posting bond(s) or giving other security reasonably acceptable to Landlord, to protect Landlord and its mortgagees, the Building and the Property from any liability, costs, damages or expenses arising in connection with such
violation and failure to cure, (iii) Tenant agrees to indemnify, defend (with counsel reasonably acceptable to Landlord) and hold Landlord and its mortgagees harmless from and against any and all liability, costs, damages, or expenses arising
in connection with such condition and/or violation, except to the extent to which such condition was caused by the negligence or willful misconduct of Landlord or Landlord’s employees, agents, contractors or invitees, (iv) Tenant shall
promptly cure any violation in the event that its appeal of such violation is overruled or rejected, (v) Tenant shall certify to Landlord’s and its mortgagees’ reasonable satisfaction that Tenant’s decision to delay such cure
shall not result in any actual or threatened bodily injury or property damage to Landlord, any tenant or occupant of the Building or the Property or any other person or entity, and (vi) this Lease is in full force and effect and no Event of
Default has occurred and is then continuing. 
 9.04. Hazardous Materials. 

(a) “Environmental Law” shall mean all statutes, laws, rules, regulations, codes, ordinances, standards, guidelines,
authorizations and orders of federal, state or local public authorities now in force or hereafter enacted, modified, or amended pertaining to the protection of the environment or to health or safety risks arising therefrom, including, but not
limited to, control of air pollution, water pollution, groundwater pollution, and the generation, manufacture, management, handling, use, sale, transportation, delivery, discharge, emission, treatment, storage, disposal, release or threatened
release of Hazardous Materials. To the extent applicable, such laws include, but are not limited to: (1) the Clean Air Act, 42 U.S.C. § 7401, et seq.; (2) the Clean Water Act, 33 U.S.C. § 1251, et seq.; (3) the Safe Drinking Water
Act, 42 U.S.C. § 300f, et seq.; (4) the Resource Conservation and Recovery Act, 42 U.S.C. § 6901, et seq.; (5) the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. § 9601, et seq.; (6) the Toxic
Substances Control Act, 15 U.S.C. § 2601, et seq.; (7) Title III of the Superfund Amendments and Reauthorization Act, also known as the Emergency Planning and Community
Right-to-Know Act, 42 U.S.C. § 11001; (8) the Hazardous Materials Transportation Act, 49 U.S.C. § 1801 et seq.; (9) federal regulations promulgated pursuant to
any of the foregoing statutes; (10) Massachusetts laws and regulations enacted in order to implement federal environmental statutes and regulations; (11) the Massachusetts Hazardous Waste Management Act, M.G.L. c. 21C; (12) the
Massachusetts Oil and Hazardous Materials Release Prevention and Response Act, M.G.L. c. 21E; (13) the Hazardous Substances Disclosure by Employers Act, M.G.L. c. 111F; (14) Massachusetts regulations promulgated pursuant to the authority
of applicable state environmental laws; and (15) local ordinances and regulations. 
 “Hazardous Materials” shall
mean, but shall not be limited to, any products, hazardous substances, hazardous waste, toxic substances, environmental, biological, pathological, chemical, radioactive materials, waste or substances, oil or petroleum products and any material,
waste or substance, which because of its quantitative concentration, chemical, biological, radioactive, flammable, explosive, infectious, or other characteristics, constitutes or may reasonably be expected to constitute or contribute to a danger or
hazard to public health, safety or welfare or to the environment, including any asbestos (whether or not friable) and any asbestos-containing materials, lead paint, waste oils, solvents and chlorinated oils, polychlorinated biphenyls (PCBs), toxic
metals, etchants, pickling and plating wastes, explosives, reactive metals and compounds, pesticides, herbicides, radon gas, urea formaldehyde foam insulation and chemical, biological and radioactive wastes, or any other materials or substances that
are mentioned under or regulated by any Environmental Law; and including any other products or materials subsequently found by an authority of competent jurisdiction (excluding the U.S. Food & Drug Administration) to have adverse effects on
the environment or the health and safety of persons. 

  
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 (b) Tenant, at its sole cost and expense, shall comply with all Environmental Laws
pertaining to the transportation, use, storage, generation, disposal, release or discharge of Hazardous Materials to, from or at the Property by Tenant or any Tenant Party, including obtaining all required permits and approvals. Provided that the
same is performed at all times in accordance with the provisions of this Lease, Tenant may generate, produce, bring upon, use, store or treat Hazardous Materials in the Premises which are (a) typically found in commercial construction sites
(which shall apply only during such time as Tenant is performing construction at the Property as provided for in this Lease), (b) cleaning products or office supplies typically used in laboratory/office space, and (c) materials otherwise used
in the ordinary course of Tenant’s operations and typically found in other leased laboratory space used for comparable purposes, as reasonably needed for Tenant’s operations and research activities, and strictly in accordance with
Environmental Laws. In all events Tenant shall comply with all applicable provisions of the standards of the U.S. Department of Health and Human Services as further described in the USDHHS publication Biosafety in Microbiological and Biomedical
Laboratories (5th Edition, December 2009) as it may be further revised, or such nationally recognized new or replacement standards as may be reasonably selected by Landlord. Except as otherwise set forth above, Tenant shall not cause or permit any
Hazardous Materials to be generated, produced, brought upon, used, stored, treated or disposed of to, from, or in or about the Property by Tenant or any Tenant Party without Landlord’s prior written consent, which may be withheld in
Landlord’s sole discretion. Any Hazardous Materials permitted to be stored on the Premises pursuant to this paragraph shall be stored in areas of the Premises exclusively designated by Tenant for such purpose to the extent required by Legal
Requirements (including the areas described in Section 2.01(f). In no event shall any Hazardous Materials be generated, stored, used or disposed of outside of the Premises except for the portions of the Property described in
Section 2.01(f). Tenant shall not dispose of Hazardous Materials from the Premises to any other location except in strict compliance with all applicable Environmental Laws, nor permit any persons acting under it to do so.
Notwithstanding the foregoing, Tenant shall not, in any event, be responsible for any Hazardous Materials to the extent such Hazardous Materials are introduced to the Property by anyone other than Tenant or any Tenant Party. 

(c) Within ten (10) Business Days after taking initial occupancy of the Premises, Tenant shall provide to Landlord a list of all Hazardous
Materials used, stored or generated by Tenant in the Premises, including quantities of each anticipated to be used, together with the material safety data sheet (“MSDS”) for each such Hazardous Material. Thereafter, within ten
(10) Business Days of Landlord’s request (which request shall not be made more than two (2) times per 12-month period), Tenant shall provide Landlord with an updated list of all Hazardous
Materials used, stored or generated by Tenant in the Premises, including quantities of each used, together with the MSDS for each such Hazardous Material. From time to time at Landlord’s request, Tenant shall execute affidavits, certifications
and the like, in form reasonably acceptable to Tenant, to the best of Tenant’s knowledge and belief, regarding the presence or absence of Hazardous Materials on the Premises, the Property or the Building used, stored, generated, disposed of or
released by Tenant or any Tenant Party. Furthermore, within fifteen (15) days after Landlord’s request, Tenant shall make available to Landlord at the Premises, for review and audit by Landlord, all of Tenant’s books and records
relating to the types and amounts of all Hazardous Materials being generated, produced, brought upon, used, stored or disposed of by or on behalf of Tenant at, on or from the Premises, together with copies of any federal, state or municipal filings
or compliance reports made by Tenant with respect to such Hazardous Materials that are required by applicable Environmental Law. Tenant agrees to pay the cost of any environmental inspection or assessment requested by any governmental agencies,
mortgagees of the Property, or by any insurance carrier to the extent that such inspection or assessment pertains to any release, threat of release, contamination, claim of contamination, loss or damage or deterioration of condition in the Premises
caused by or alleged to be caused by Tenant or any Tenant Party (collectively, “Environmental Incidents”). Notwithstanding anything to the contrary contained in this Section 9.04, to the extent that any
disclosure, affidavit or similar document to be provided to Landlord under this Section 9.04 would otherwise be required to disclose proprietary information concerning chemicals, substances or materials synthesized by
Tenant from constituent Hazardous Materials, such disclosure may exclude such proprietary information provided that the constituent Hazardous Materials (but not the manner, quantities or concentrations in which they are combined to form such
chemicals, substances or materials) are identified therein. 
 (d) Landlord shall not be liable to Tenant or any Tenant Party or to any
person or governmental authority whatsoever for any release of Hazardous Materials brought to the Premises by or on behalf of Tenant at any time during the Term, except to the extent caused by the negligence or willful misconduct of Landlord or its
employees, agents, contractors or invitees. Landlord shall have the right, from time to time during the Term, but not more than once in any 12-month period unless either Tenant is in default of its obligations
under this Section 9.04 or Landlord has reason to believe that a release of Hazardous Materials has occurred on, at or from the Premises caused by Tenant or a Tenant Party, to enter upon the Premises upon reasonable prior
notice to Tenant to perform environmental audits relating to the operations of Tenant and all those claiming through Tenant on the Premises, including (i) reviewing records relating to compliance with Environmental Laws and industry standards
applicable to the generation, handling, use, storage and disposal of Hazardous Materials, (ii) observing techniques for handling, storing, using and disposing of Hazardous Materials, (iii) reviewing documentation relating to the off-Premises disposal of Hazardous Materials from the Premises, and (iv) conducting such tests as Landlord reasonably deems appropriate, all such work to be performed at Landlord’s sole expense except as
otherwise provided in the next sentence. In addition to, and not in limitation of the rights provided in the immediately preceding sentence, if required by any governmental agency or if Landlord reasonably believes that a release of Hazardous
Materials has 

  
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occurred on or from the Premises by Tenant or any Tenant Party or a threat of release exists arising from Hazardous Materials not being handled, stored, used or disposed of by Tenant or any
Tenant Party in accordance with the requirements of this Lease and all applicable Environmental Laws, then Landlord may, but need not, perform appropriate testing and the reasonable costs thereof shall be reimbursed to Landlord by Tenant within ten
(10) Business Days of demand, as Additional Rent, except that Landlord shall bear the cost of such testing if (i) Landlord (rather than a governmental agency) requested such testing and (ii) such testing determines that no such
release has occurred as a result of the actions of Tenant or any Tenant Party and that Hazardous Materials are being handled, used, stored and disposed of in compliance with the terms of this Lease and all applicable Environmental Laws. Tenant shall
cooperate with Landlord in connection with any environmental audits or other inspections or testing performed by Landlord pursuant to this Section. Landlord and any third parties conducting such audits and/or inspecting Tenant’s books and
records shall enter into reasonable non-disclosure and confidentiality agreements with Tenant, in form reasonably acceptable to Landlord and Tenant. 

(e) If any transportation, generation, storage, use or disposal of Hazardous Materials on or about the Premises, the Building or the Property
by Tenant or any Tenant Party, results in the threat of release, release onto, or other contamination of any portion of the Property or adjacent areas, including building or parking areas, soil or surface or ground water, or any loss or damage to
person(s) or property, Tenant agrees to: (a) notify Landlord immediately, once Tenant has knowledge or has received notice, of any release, threat of release, contamination, claim of contamination, loss or damage, and (b) after
consultation with Landlord, clean up the release, threat of release, or contamination in compliance with all applicable Environmental Laws or Legal Requirements. In the event of such contamination, Tenant agrees to cooperate fully with Landlord and
to provide such documents, affidavits and information as may be reasonably requested by Landlord (1) to comply with any Environmental Law or Legal Requirement, (2) to comply with the request of any lender, purchaser or tenant, and/or
(3) for any other reason reasonably deemed necessary by Landlord. Tenant shall notify Landlord promptly in the event of any spill or other release of any Hazardous Material at, in, on, under or about the Premises or the Property by Tenant or
any Tenant Party that is required to be reported to a governmental authority under any Environmental Law or Legal Requirement, shall promptly forward to Landlord copies of any written notices received by Tenant relating to alleged violations of any
Environmental Law or Legal Requirement and shall promptly pay when due any fine or assessment against Landlord, Tenant, the Premises or the Property relating to any violation of any Environmental Law or Legal Requirement by Tenant or any Tenant
Party, to the extent that compliance with such Environmental Law or Legal requirement is Tenant’s obligation. If any governmental authority files a lien against the Premises or the Property due to any act or omission, intentional or
unintentional, of Tenant or any Tenant Party that results or has resulted in the releasing, spilling, leaking, leaching, pumping, emitting, pouring, emptying or dumping of any Hazardous Material, Tenant shall, within ten (10) Business Days from
the date that Tenant is first given notice of such lien (or within such shorter period of time as may be specified by Landlord if such governmental authority takes steps to enforce such lien) either (A) pay the claim and remove the lien or
(B) furnish a cash deposit bond or such other security as is reasonably satisfactory in all respects to Landlord and sufficient to discharge the lien completely. 

(f) Any increase in the premium for necessary insurance on the Premises or the Property which arises from Tenant’s use and/or storage of
Hazardous Materials beyond those typically found in office and laboratory space used for comparable purposes shall be solely at Tenant’s expense. Tenant shall procure and maintain at its sole expense such additional insurance as may be required
to comply with any requirement of any federal, state or local government agency with jurisdiction. 
 (g) Except to the extent caused by the
negligence or willful misconduct of Landlord, its employees, agents, contractors and/or invitees or the Indemnitees, Tenant shall indemnify, defend with counsel reasonably acceptable to Landlord and hold the Indemnitees fully harmless from and
against any and all liability, loss, suits, claims, actions, causes of action, proceedings, judgments, demands, costs, penalties, damages, fines and expenses, including reasonable attorneys’ fees (including reasonable attorneys’ fees of
Landlord’s counsel and costs of litigation), consultants’ fees, laboratory fees and clean-up costs, and the costs and expenses of investigating and defending any claims or proceedings, resulting
from, or attributable to (i) the presence of any Hazardous Materials on or in the Premises, the Building or the Property arising from the act, omission or negligence of Tenant or any Tenant Party, or arising out of the generation, storage,
treatment, handling, transportation, disposal or release by Tenant or any Tenant Party of any Hazardous Materials at or near the Premises or the remainder of the Property from and after such time, and which require remedial action under applicable
Environmental Laws, (ii) any violation(s) by Tenant or any Tenant Party of any Environmental Laws, (iii) any Environmental Incidents (as defined above) and (iv) any breach by Tenant of its covenants and obligations under this
Section 9.04 or Section 10.07. 

  
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 (h) Landlord shall indemnify, defend with counsel reasonably acceptable to Tenant and hold
Tenant fully harmless from and against any and all liability, loss, suits, claims, actions, causes of action, proceedings, judgments, demands, costs, penalties, damages, fines and expenses, including reasonable attorneys’ fees (including
reasonable attorneys’ fees of Tenant’s counsel and costs of litigation), consultants’ fees, laboratory fees and clean-up costs, and the costs and expenses of investigating and defending any
claims or proceedings, resulting from, or attributable to the presence of any Hazardous Materials on or in the Premises, the Building or the Property (i) which were present prior to the Delivery Date and which require remedial action under
applicable Environmental Laws, or (ii) which are generated, stored, treated, handled, transported, disposed of or released by Landlord or any employee, agent, contractor or invitee of Landlord at any time and which require remedial action under
applicable Environmental Laws. 
 (i) The provisions of this Section 9.04 shall survive the expiration of the Term
or the earlier termination of this Lease. 
 (j) Reference is made to Section 10.07 for provisions relating to the
decommissioning of the Premises by Tenant upon the expiration of the Term or the earlier expiration of this Lease. 
 9.05. Signs.
Except as expressly otherwise provided in this Section and except for the Initial Tenant Work, no sign, antenna or other structure or thing shall be erected or placed on the Premises or any part of the exterior of the Building or erected so as
to be visible from the exterior of the Building, without first securing the written consent of Landlord. Landlord, at Landlord’s cost, shall provide building standard signage within the Building lobby identifying Tenant. Landlord shall also
provide to Tenant Tenant’s Pro Rata Share of entries on any Building directory maintained by Landlord within the Building from time to time within the Building. Tenant shall have the right to install one (1) sign on the Building facade, at
a location approved in advance by Landlord, subject to (i) the approval of Landlord as to the size, shape, color, method of illumination and method of installation of such sign (which approval shall not be unreasonably withheld, delayed or
conditioned), and (ii) the issuance to Tenant of all licenses, permits and approvals required from any governmental authority in connection with the installation or maintenance of such sign. Landlord hereby approves the drawing of a Building
façade sign attached hereto as Exhibit L, as to the approximate size, design and location of the sign, and that the sign may be illuminated (all subject to Tenant’s obligation as to licenses, permits and approvals
with respect to such sign as set forth in this Section). The final size, design and location and the method of illumination of such Building façade sign shall be subject to Landlord’s approval, not to be unreasonably withheld,
conditioned or delayed. Tenant shall not have the right to install any monument sign or any name or logo plate on any monument sign which is from time to time installed by Landlord. Tenant shall be solely responsible, at its sole cost and expense,
for (A) obtaining and maintaining in full force and effect all licenses, permits and approvals required from any governmental authority in connection with the installation or maintenance of all exterior signage, and (B) the installation,
maintenance and repair of all exterior signage, and shall maintain the same in good condition at all times. Tenant shall further be required, at its sole cost and expense, upon the expiration or earlier termination of the Term, to remove
Tenant’s signage installed on the Building facade and to repair all damage caused by such removal to Landlord’s reasonable satisfaction. 

9.06. Landlord’s Access. Subject to the provisions of this Section, Landlord or its agents may enter the Premises at all reasonable
times to show the Premises to potential buyers, investors, tenants (but with respect to potential tenants, only in the final twelve (12) months of the Term) or other parties; to inspect and conduct tests in order to monitor Tenant’s
compliance with Legal Requirements governing Hazardous Materials; for purposes described in Sections 2.01, 9.04, 10.03 and/or 10.04(b); or for any other purpose Landlord reasonably deems necessary. No prospective lender, purchaser, or tenant
claiming through Landlord shall be permitted access to the Premises without a representative of Landlord present. Except in the event of an emergency posing an imminent threat of personal injury or damage to the Property (in which event notice shall
be provided as soon as reasonably practicable), Landlord shall give Tenant at least one (1) Business Day’s prior notice (which may be oral) of any entry by Landlord into the Premises. Unless otherwise authorized by Tenant in advance, any
entry into the following secured areas within the Premises: laboratory space and areas identified in Section 2.01(f) for the storage of Hazardous Materials, other than in case of emergency shall occur only with a representative of Tenant or its
authorized designee present and Tenant agrees to make a representative available for such purpose during Normal Business Hours, Monday through Friday; provided, however, if Tenant’s representative fails to appear for a scheduled
inspection or access by Landlord, Landlord may nevertheless proceed with such scheduled inspection or access. Notwithstanding the foregoing, in case of emergency, Landlord may enter any part of the Premises without prior notice to Tenant provided
that Landlord provides Tenant with notice of such entry as soon as reasonably possible thereafter. Landlord shall use reasonable efforts not to interfere with Tenant’s use and occupancy of the Premises when exercising Landlord’s rights
under this paragraph. Landlord agrees to comply with Tenant’s reasonable requirements (including without limitation requirements in connection with access, health, safety, and/or security checks) in connection with non-emergency access to the Premises to the extent to which the same are consistent with the provisions of this Section and have been provided to Landlord in writing prior to any such entry. Upon request by Tenant,
Landlord and any parties who are given access to the above-described secured areas shall enter into reasonable confidentiality agreements with Tenant, in form reasonably acceptable to both Landlord and Tenant, prior to such access (except in the
event of an emergency). 

  
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 9.07. Landlord’s Rules and Regulations. Tenant and all Tenant Parties shall
observe Landlord’s rules and regulations (the “Rules and Regulations”) promulgated (and amended from time to time) with respect to the occupation and use of the Building and the Property and of general applicability to all
tenants of the Building and the Property (as well as all Rules and Regulations which are applicable only to all tenants which are using their leased premises for purposes similar to Tenant), provided that (i) Tenant receives reasonable prior
written notice of such Rules and Regulations, and (ii) the same are not inconsistent with the provisions of this Lease. All of Landlord’s Rules and Regulations shall be administered in an even handed manner among all occupants of the
Building using their leased premises for similar purposes. Landlord’s initial Rules and Regulations are set forth in Exhibit G attached hereto. The Rules and Regulations may also include, if any portion of the Building is being used as
an animal facility at any time, provisions specifically relating thereto. Nothing contained in this Lease shall be construed to impose upon Landlord any duty or obligation to enforce the terms, covenants or conditions in any other lease as against
any other tenant and Landlord shall not be liable to Tenant for violation of the same by any other tenant or such other tenant’s servants, employees, agents, contractors, visitors, invitees or licensees. 

9.08. Compliance With Insurance Requirements. Tenant and all Tenant Parties shall at all times comply with the terms of any policy of
insurance maintained by Landlord or Tenant and applicable to the Property or the Premises or any portion of either, and all requirements of the issuer of any such policy (in each case, with respect to insurance policies maintained by Landlord, to
the extent Landlord has provided written notice to Tenant of the requirements of such policy(is) or issuer(s)), and all orders, rules, regulations and other requirements of the National Board of Fire Underwriters (or any other body exercising
similar functions) (collectively, “Insurance Requirements”).  
 9.09. Floor Load; Heavy Machinery. Tenant shall not
place a load upon any floor of the Premises exceeding the floor load per square foot of area which such floor was designed to carry and which is allowed by law. Tenant acknowledges receipt from Landlord of the foregoing floor load information.
Landlord reserves the right to prescribe the weight and position of all heavy machinery and mechanical equipment, which shall be placed so as to distribute the weight. Heavy machinery and mechanical equipment shall be placed and maintained by Tenant
at Tenant’s expense in settings sufficient in Landlord’s reasonable judgment to absorb and prevent vibration, noise and annoyance. Tenant shall not move any heavy machinery, heavy equipment, freight, bulky matter, or fixtures into or out
of the Building without Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. If such machinery, equipment, freight, bulky matter or fixtures requires special handling, Tenant agrees to
employ only persons holding a Master Rigger’s License to do said work, and that all work in connection therewith shall comply with applicable Legal Requirements. Any such moving shall be at the sole risk and hazard of Tenant and Tenant will
defend, indemnify and save Landlord harmless against and from any liability, loss, injury, claim or suit resulting directly or indirectly from such moving, except to the extent caused by the negligence or willful misconduct of Landlord or its
employees, agents or contractors. Proper placement of all such heavy machinery, etc., in the Premises shall be Tenant’s responsibility. 

9.10. LEED/Energy Conservation Measures . Tenant acknowledges that Landlord intends to pursue certification at either a Gold or Silver
level in the Leadership in Energy and Environmental Design Core & Shell program (“LEED-CS”), and has designed and constructed the Building to achieve that goal. Tenant further
acknowledges and agrees that such certification will require Tenant to comply with the following requirements in connection with the design, construction, use and operation of its Premises: 

 

	 	(1)	 Mandatory Leadership in Energy and Environmental Design (LEED) Tenant Compliance. Tenant
shall meet the following design and construction requirements in support of and in compliance with the LEED-CS prerequisites and credits attempted within the base-building
LEED-CS certification application: 

  

	 	a.	 EAp3 Fundamental Refrigerant Management: Any additional HVAC & Refrigeration equipment and/or
systems installed by Tenant must comply with the following: “zero use of chlorofluorocarbon (CFC)-based refrigerants in new heating, ventilating, air conditioning and refrigeration (HVAC&R) systems. Small HVAC units (defined as
containing less than 0.5 pounds (228 grams) of refrigerant) and other equipment, such as standard refrigerators, small water coolers and any other equipment that contains less than 0.5 pounds (228 grams) of refrigerant, are not subject to the
requirements of this prerequisite”.  

  
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	 	b.	 IEQp1 Minimum Air Quality Performance: All mechanical ventilation systems installed by Tenant must
“meet the minimum requirements of Sections 4 through 7 of ASHRAE Standard 62.1-2007, Ventilation for Acceptable Indoor Air Quality. Mechanical ventilation systems must be designed
using the ventilation rate procedure or the applicable local code, whichever is more stringent.” Compliance must be demonstrated through calculations performed in alignment with the Ventilation Rate Procedure methodology as per
section 6.2 of the ASHRAE 62.1-2007 standard. 

  

	 	c.	 IEQp2 Environmental Tobacco Smoke Control (ETS): Tenant is required to “Prohibit smoking in the
building. Prohibit on-property smoking within 25 feet (8 meters) of entries, outdoor air intakes and operable windows. Provide signage to allow smoking in designated areas, prohibit smoking in designated areas
or prohibit smoking on the entire property.”  

  

	 	(2)	 Mandatory Tenant Energy Conservation Measures (ECMs). Tenant shall adhere to the following
performance requirements to support and align with the Energy Conservation Measures incorporated in the base-building Core and Shell building systems and building envelope design and the LEED-CS whole building
energy model: 

  

	 	a.	 Lighting Power Density: The installed interior lighting power in the Premises must be designed to be
equal to or less than 0.75 Watts/SF using the Building Area Calculation Method as referenced in ASHRAE 90.1-2007. 

  

	 	b.	 Lighting Controls: Office tenants are required to provide the following
lighting controls: 

  

	 	•	 	 Daylight dimming: The Premises shall be designed to meet the following daylight dimming requirements:

  

	 	•	 	 Automatic daylight harvesting controls must be provided in all tenant spaces that are within 15 ft of the
exterior walls. 

  

	 	•	 	 All lighting in these areas must be automatically controlled based on available daylight and is dimmed from 100%
to 30% of the light output with a proportional power input reduction (from 100% to 30% of the power input). 

  

	 	•	 	 The light level setpoint shall be 50 fc at a horizontal plane that is 2.5 ft above the floor.

  

	 	•	 	 Occupancy Sensors on Lighting: Occupancy sensors must be provided for light control in all tenant spaces.

 Beyond adhering to the requirements of the above listed LEED-CS prerequisites and credits,
Tenant, at its option and at its own cost and expense, may elect to pursue third party certification under the LEED 2009 program for Commercial Interiors. Even if third-party certification is not pursued, Tenant shall be required to comply with the
aforementioned LEED prerequisites and credits. 
 9.11. Emergency Generator. 

(a) Subject to Landlord’s prior written approval of the design and specifications therefor (which approval shall not be unreasonably
withheld, conditioned or delayed), Tenant shall have the right, at its sole cost and expense (except to the extent to which the installation cost thereof is paid through the Landlord’s Allowance), to install, operate, repair, maintain and
replace a back-up generator reasonably necessary for Tenant’s requirements including natural gas or fuel supply and tank therefor reasonably necessary for Tenant’s requirements (not to exceed
applicable code requirements), and all reasonably necessary cabling and related appurtenances (collectively, the “Generator”) to serve the Premises at the location identified on Exhibit A attached hereto or in a location in
or around the Building or the Parking Facilities as otherwise agreed upon by the parties, if Tenant elects to install the Generator. 
 (b)
No Rent shall be charged to Tenant for the area to be occupied by the Generator and the areas required to connect the Generator to the appropriate locations within the Premises (but if the Generator occupies any parking spaces in the Parking
Facilities, such spaces shall reduce the required Parking Allotment by the number of such occupied spaces). Tenant will be solely responsible for all utility charges incurred with respect to the Generator, as separately metered (at Tenant’s
expense). 

  
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 (c) Except to the extent the Generator is installed as part of the Initial Tenant Work in
accordance with the provisions of the Work Letter, installation of the Generator and any related cabling, conduit and appurtenances will be governed by the applicable provisions of this Lease relating to Tenant Work. Tenant will submit to Landlord
at least thirty (30) days prior to the proposed installation date(s) Tenant’s proposed plans and specifications relating to the installation, operation and use of the Generator and all associated lines. Except to the extent the Generator
is installed as part of the Initial Tenant Work in accordance with the provisions of the Work Letter, Tenant may not commence any work to install a Generator until it has received Landlord’s prior written approval (not to be unreasonably
withheld, delayed or conditioned) of such plans and specifications. Tenant, at its sole cost and expense, shall comply with all applicable Legal Requirements and restrictive covenants affecting the Property and Landlord’s reasonable directives
relating to the installation, operation, maintenance and repair of the Generator, including, but not limited to (i) obtaining and maintaining (or causing to be obtained and maintained) and complying with the provisions of all applicable permits
required for the installation, operation, maintenance and repair of the Generator, (ii) implementing spill prevention control and countermeasures and containment plan(s) (as required by federal, state, or local regulations) or best management
practices plan(s), (iii) providing evidence of insurance covering such facilities, and (iv) maintaining and inspecting such facilities and related equipment and keeping records related thereto. Tenant will maintain and repair the Generator in
good operating condition throughout the Term, at Tenant’s sole cost and expense. Any replacement (excluding insured casualty), all maintenance and repair of the Generator and all governmental compliance required in connection with the Generator
will be Tenant’s sole responsibility and Tenant’s sole cost and expense; provided, however, if Tenant fails to commence such maintenance and repair within thirty (30) days (unless an emergency exists, in which event Tenant shall
promptly commence such curative work and thereafter diligently prosecute the same to completion) after written notice from Landlord and thereafter diligently prosecutes the same to completion, then Landlord may elect to perform such maintenance at
Tenant’s sole cost and expense. Upon Landlord’s request, Tenant will promptly provide Landlord with copies of all records relating to the installation, operation, maintenance and repair of the Generator. 

(d) Tenant may not use the Generator for any purpose other than solely in connection with Tenant’s occupancy of the Premises for the
Permitted Use and in accordance with any applicable permit(s) pertaining to the Generator. Tenant may not use the Generator to serve other occupant(s) of the Property. This provision does not modify Tenant’s permitted use of the Premises, and
does not relieve Tenant of any environmental liability under this Lease. 
 (e) At any time within ninety (90) days prior to the
expiration of the Lease, or earlier termination of the Lease, Landlord may, at Tenant’s cost and expense, cause a qualified environmental consultant reasonably acceptable to Landlord and Tenant to perform an environmental investigation to
determine whether a release of any Hazardous Materials has occurred during the Term of this Lease with respect to the Generator. Within thirty (30) days following the expiration or earlier termination of this Lease, Tenant may elect (but shall
not be required) to remove the Generator, but if Tenant elects to do so, Tenant shall promptly (i) remove the Generator (and any related fuel tanks, conduit, fuel lines, cabling and other appurtenances associated therewith), (ii) restore the
affected areas to their original condition prior to the installation of the Generator, in accordance with plans and specifications reasonably acceptable to Landlord and all applicable Legal Requirements, and (iii) repair any damage to the
Premises or the Property caused by the removal of the Generator. Tenant shall perform any required environmental remediation for the release of any Hazardous Materials in connection with the Generator caused by Tenant or any Tenant Party during the
Term of this Lease in accordance with applicable Legal Requirements, all at Tenant’s sole cost and expense. If the environmental investigation performed by the environmental consultant as provided above confirms the release of any Hazardous
Materials caused by Tenant or any Tenant Party in connection with the Generator, Tenant must thereafter perform any clean up or remediation required by applicable Legal Requirements and in accordance with applicable Legal Requirements, and document
with a report prepared by a qualified environmental consultant reasonably approved by Landlord, evidencing either no impact to soil and groundwater exceeding state cleanup criteria for the use of the site, or that any impacted soil or groundwater
has been remediated in a manner and to a level meeting the applicable state cleanup criteria, together with any applicable state assurance or closure. 

(f) Tenant will promptly report to Landlord any spill or release and any written citations or notices of violation of any Legal Requirements
received by Tenant in connection with the Generator, and will provide Landlord with copies thereof. Such notification to Landlord will not relieve Tenant from its obligations to notify governmental agencies. Any cleanup or remediation will be
completed by Tenant in accordance with applicable Environmental Laws and in a manner and to a level meeting the applicable state cleanup criteria, together with any applicable state assurance or closure. 

(g) Tenant shall make annual inspections, at Tenant’s expense, to ensure regulatory compliance and the proper operation, maintenance and
repair of the Generator, and will forward copies of such inspection reports to Landlord promptly following receipt of Landlord’s written request(s) therefor. 

  
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 9.12. Rooftop Rights. 

(a) Tenant shall be permitted, in locations on the roof of the West Wing of the Building as approved by Landlord in writing in advance, to
install, operate, maintain, repair and remove, or Landlord may install on behalf of Tenant, all at Tenant’s sole cost and expense and for use solely by Tenant in connection with its business operations conducted in the Premises and not for use
by non-occupant third parties, (i) telecommunications and data processing equipment (including but not limited to satellite dishes, generators, cell boosters and antennae), and related wiring from the
roof to the interior portions of the Premises to the extent reasonably necessary (collectively, the “Rooftop Communications Equipment”), and (ii) such supplementary HVAC and other equipment
serving solely the Premises, consistent with Tenant’s use of the Premises (collectively, with the Rooftop Communications Equipment, the “Rooftop Equipment”), provided the same complies with
all Legal Requirements. The Rooftop Equipment shall be screened from exterior view in a manner reasonably acceptable to Landlord. During the Term, Tenant shall not be required to pay any monthly rental or license fee with respect to Tenant’s
Rooftop Space or any of the Rooftop Equipment. Tenant shall be responsible for all costs and expenses associated with or relating to the Rooftop Equipment, including installation, operation, maintenance, use, removal and insuring of the Rooftop
Equipment (same being deemed Tenant’s personal property for purposes of this Lease), and shall reimburse Landlord any reasonable, actual out-of-pocket costs
incurred by Landlord in connection therewith, including, but not limited to any costs for electric power and HVAC (if any) that Tenant uses in the Building for the Rooftop Equipment, as separately metered. Landlord shall have the right to permit
other tenants of the Building to lease space on the roof of the Building for such other party’s own rooftop antennae, satellite dishes and other telecommunications equipment to be used in the conduct of such tenant’s business operations in
the Building and not elsewhere, provided that (i) Tenant shall continue to have full access to the Rooftop Equipment, (ii) Tenant’s right to install, use, improve, add to and replace Rooftop Equipment shall be non-exclusive and shall be shared on a pro rata 

  
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basis with any such rights granted to other tenant(s) in the Buildings, (iii) Landlord shall not install, and shall prohibit the installation and/or operation by any other party of, any
additional microwave dishes/earth satellite disks, antennae, towers and/or other structures on the Roof which would, in Tenant’s reasonable judgment, interfere with Tenant’s use of the Rooftop Equipment which is then in place. 

(b) Prior to installing any Rooftop Equipment, Tenant shall submit to Landlord for its approval (which approval shall not be unreasonably
withheld, delayed or conditioned) plans and specifications that (i) specify in detail the design, location, size (and, with respect to Rooftop Communications Equipment, the frequency) of the Rooftop Equipment and (ii) are sufficiently
detailed to allow for the installation of the Rooftop Equipment in a good and workmanlike manner and in accordance with all Legal Requirements. Following Landlord’s approval of such plans, Tenant shall obtain all permits required for the
installation and operation, thereof, and copies of all such permits must be submitted to Landlord before Tenant begins to install the Rooftop Equipment. Tenant shall be permitted to select a contractor of its choice to undertake the installation of
the Rooftop Equipment, subject to Landlord’s approval (which approval shall not be unreasonably withheld, delayed or conditioned). Tenant shall install all Rooftop Equipment in a good and workmanlike manner, and shall maintain and use the
Rooftop Equipment in accordance with all applicable Legal Requirements. Tenant shall also have the right to install reasonably necessary conduit and sleeving from the roof to the points of connection within the Premises. Tenant shall be responsible
for all costs of installation (including structural reinforcing or modifications required to be made to the roof in order to support Tenant’s Rooftop Equipment), repair, maintenance and removal with respect to the Rooftop Equipment. Tenant
shall thereafter maintain all permits necessary for the maintenance and operation of the Rooftop Equipment while it is on the Property. Tenant shall maintain the Rooftop Equipment in good repair and condition and in such a manner so as not to
interfere in any material respect with any other satellite, antennae or other transmission facility on the roof or elsewhere in the Building which was installed and operating prior to Tenant’s installation of the Rooftop Equipment which is
claimed to be causing such interference. Tenant shall repair any damage to the Building caused by or relating to the Rooftop Equipment, including that which is caused by its installation, maintenance, use or removal, and Tenant shall reimburse
Landlord for any out-of-pocket costs and expenses incurred by Landlord for any actual damage to the Property, including any damage resulting from penetrations of the
Roof with respect to such installation, maintenance or use. 
 (c) All work relating to the Rooftop Equipment shall, at Landlord’s
request, be coordinated with Landlord’s roofing contractor so as not to void any warranty for the Roof. 
 ARTICLE 10: CONDITION AND MAINTENANCE OF
PREMISES AND PROPERTY 
 10.01. Existing Conditions. Tenant acknowledges that except for any express representations contained in
this Lease, neither Landlord nor any person acting under or on behalf of Landlord has made any representation as to the condition of the Premises, the Building or the Property, or the suitability of the Premises, the Building or the Property for
Tenant’s intended use. Tenant represents and warrants that Tenant has made its own inspection and inquiry regarding the Premises, the Building and the Property and is not relying on any representations of Landlord or any broker or persons
acting on behalf of Landlord other than as set forth in this Lease. 
 10.02. No Landlord Liability. Landlord shall not be liable for
any damage or injury to the persons, property or business (including loss of revenue, profits or data) of Tenant or any Tenant Party, provided, however, that this Section 10.02 shall not exempt Landlord from
liability for Landlord’s negligence or willful misconduct or the negligence or willful misconduct of its agents, employees, contractors, and/or invitees, or Landlord’s breach of its obligations herein. This exemption shall apply whether
such damage or injury is caused by (among other things): (i) fire, steam, electricity, water, gas, air, sewage, sewer gas or odors, snow, ice, frost or rain; (ii) the breakage, leakage, obstruction or other defects of pipes, faucets,
sprinklers, wires, appliances, plumbing, windows, air conditioning or lighting fixtures or any other cause; (iii) explosion, electrical or electromagnetic emissions; (iv) any casualty or Taking; (v) theft; (vi) conditions in or about
the Property or the Building; or (vii) any act or omission of any other tenant. Tenant hereby agrees that, to the maximum extent permitted by law, all merchandise, furniture, fixtures and property of every kind, nature and description of Tenant
or any Tenant Party which may be in or upon the Premises, the Building or the Property, shall be at the sole risk and hazard of Tenant, and that if the whole or any part thereof shall be damaged, destroyed, stolen or removed from any cause or reason
whatsoever, no part of said damage or loss shall be charged to, or borne by, Landlord, except to the extent caused by Landlord’s negligence or willful misconduct or the negligence or willful misconduct of its agents, employees, contractors,
and/or invitees, or Landlord’s breach of its obligations herein. 

  
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 10.03. Landlord’s Repair and Maintenance Obligations. Subject to the provisions
of Section 16.09, and except for damage caused by fire, other casually or taking (which is dealt with below), and damage caused by the act or omission of Tenant or any Tenant Party, Landlord shall, at its sole cost and
expense and not to be reimbursed as Operating Expenses, keep the foundation, roof (including the roof membrane), walls, foundations, floor slabs and other structural elements of the Building (excluding any structural elements added to the Building
as part of the Initial Tenant Work or other Tenant Work, which shall be Tenant’s responsibility), columns and beams, and exterior walls and windows of the Building, as well as the underground and under-slab plumbing lines serving the Building,
in good order, condition and repair, reasonable wear and tear excepted. Further subject to the provisions of Section 16.09, and except for damage caused by fire, other casually or taking (which is dealt with below), and damage caused by the act
or omission of Tenant or any Tenant Party, Landlord shall keep the Building Systems (including the HVAC, plumbing, electrical, mechanical and other systems serving the Premises in common with other portions of the Building), to the extent not
serving the Premises or another tenant’s premises exclusively, and the common areas of the Building and the Property, in good order, condition and repair, reasonable wear and tear excepted. Landlord shall make any repairs or replacements to the
Building, the Premises or the Property, to the extent such repair or replacement was necessitated by Landlord’s negligence or willful misconduct or the negligence or willful misconduct of its agents, employees, contractors, and/or invitees or
Landlord’s breach of its obligations herein, at its sole cost and expense and not to be reimbursed as an Operating Expense. Landlord shall cause the common areas of the Building and the Property to be kept clean and free from rubbish and
debris, and the paved portions of the common areas of the Property to be free from appreciable accumulation of ice and snow. Except to the extent caused by Landlord’s negligence or willful misconduct or the negligence or willful misconduct of
its agents, employees, contractors, and/or invitees, or Landlord’s breach of its obligations herein, Landlord shall not be obligated to maintain, repair or replace any interior windows, doors, plate glass, or the surfaces of walls within the
Premises, or any fixtures, components or equipment located within the Premises or elsewhere which serve the Premises exclusively, all of which shall be Tenant’s obligation. Tenant shall promptly report to Landlord any defective condition known
to it that Landlord is required by the provisions of this Section to repair. Tenant waives the benefit of any present or future law that provides Tenant the right to repair the Premises or the Property at Landlord’s expense or to abate or
reduce the Rent or to terminate this Lease because of the condition of the Property or the Premises to the extent such benefit of law may be waived by Tenant; provided, however, that the foregoing waiver shall not be deemed to waive any
rights expressly granted to Tenant pursuant to the provisions of Section 6.03 of this Lease. Tenant shall not be entitled to any abatement of Rent, nor shall Landlord incur any liability, by reason of inconvenience,
annoyance or injury to Tenant arising from any repairs, alterations, additions, replacements or improvements made by Landlord, or any related work undertaken by Landlord in accordance with the provisions of this Lease provided Landlord complies with
the terms of Section 9.06 regarding access to the Premises and provided Landlord takes commercially reasonable steps to minimize any interference with Tenant’s operations. Notwithstanding the fact that Landlord may
provide security services at the Property or Building at any time during the term of this Lease, (i) Tenant hereby releases Landlord from any claim for injury to persons or damage to property asserted by Tenant or any Tenant Party that is
suffered or occurs in or about the Premises or in or about the Building or Property or the common areas appurtenant thereto by reason of the act of any intruder or any other person in or about the Premises, Building or Property, and
(ii) Landlord shall not be deemed to owe Tenant or any other person any duty or standard of care as a result of Landlord’s provision of such security services. All costs and expenses incurred by Landlord in connection with the performance
of any obligation set forth in this Section 10.03 shall be included in Operating Expenses except to the extent otherwise expressly provided above in this Section. 

Throughout the Term, Landlord shall maintain a bicycle storage area, comparable to the existing bicycle storage area in the Building for Tenant’s use (in
common with other occupants of the Building). 
 10.04. Tenant’s Obligations. 

10.04(a) Repair and Maintenance. Except for work that Section 10.03 requires Landlord to do and subject to
Section 16.09, Tenant, at its sole cost and expense: shall keep the Premises (including all Initial Tenant Work, other Tenant Work, Tenant Property, and all fixtures, systems and equipment now or hereafter on the Premises or elsewhere that
exclusively serve the Premises regardless of whether or not the same are part of a Building System), together with any interior windows, doors, interior plate glass, and the inner surfaces of walls within the Premises, in at least as good order,
condition and repair as they are in on the Delivery Date or may be thereafter put in during the Term, reasonable wear and tear, damage caused by fire, other casualty or taking (which is dealt with below) and damage caused by the negligence or
willful misconduct of Landlord, Landlord’s agents, employees, or contractors excepted; shall keep in a secure and sanitary condition all trash and rubbish temporarily stored at the Premises; and shall make all repairs and replacements and do
all other work necessary for the 

  
 32 

 
foregoing purposes, whether the same may be ordinary or extraordinary, foreseen or unforeseen. Without limitation, Tenant shall be responsible for the maintenance, repair and replacement of all
plumbing, heating, ventilating and air-conditioning systems and other mechanical systems (whether or not part of the Building Systems) wherever located that exclusively serve the Premises, and Tenant shall
secure, pay for, and keep in force contracts with appropriate and reputable service companies approved by Landlord (which approval shall not be unreasonably withheld, conditioned or delayed) providing for the regular maintenance of such systems to
the extent that such systems exclusively serve the Premises. All repairs and replacements required to be made by Tenant hereunder shall be equal in quality and class to the original work. No storage shall be permitted outside of the Premises except
as otherwise expressly provided in this Lease. Storage inside the Premises shall be provided in a manner not visible from outside the Premises. 

10.04(b) Landlord’s Right to Cure. If Tenant does not perform any of its obligations under
Section 10.04(a), Landlord upon twenty (20) days’ prior notice to Tenant (or in the case of an emergency, with notice provided as soon as reasonably practicable) may perform such maintenance, repair or replacement
on Tenant’s behalf, and Tenant shall reimburse Landlord, as Additional Rent, for all costs reasonably incurred, together with an Administrative Charge (as defined in Section 13.02(e)), immediately upon demand. 

10.05. Tenant Work 

10.05(a) General. “Tenant Work” shall mean all work, demolition, installations, improvements, additions and alterations
made by or on behalf of Tenant in or to the Premises or, when expressly permitted by Landlord in advance, on or to any other portion of the Property. Without limitation, Tenant Work includes any penetrations in the walls, partitions, ceilings or
floors and all attached carpeting, all signs visible from the exterior of the Premises, and all changes in the exterior appearance of the windows of the Premises (including shades, curtains and the like). All Tenant Work shall be subject to
Landlord’s prior written approval (which approval shall not be unreasonably withheld, conditioned, or delayed) and shall be arranged and paid for by Tenant, all as provided herein; provided that any interior non-structural Tenant Work (including any series of related Tenant Work projects) that (a) costs less than the “Tenant Work Threshold Amount” (which shall be $50,000 in each instance or series
of related projects, provided that from and after the point at which the aggregate cost of Tenant Work proposed by Tenant in any Lease Year exceeds $100,000, all Tenant Work proposed during such Lease Year shall be deemed to exceed the Tenant
Work Threshold Amount and shall require Landlord’s prior written approval), and (b) does not materially adversely affect any structural component of the Building, or any elevators, fire-safety, telecommunications, curtain wall, electrical,
heating, ventilation, plumbing or any other mechanical system of the Building (collectively, the “Building Systems”), (c) does not materially adversely affect any penetrations in or otherwise materially adversely affect any walls,
floors, roofs, or other structural elements of the Building, or the curtain wall, and (d) does not include any signs visible from the exterior of the Premises or any change in the exterior appearance of the windows in the Premises (including
shades, curtains and the like) shall not require Landlord’s prior approval if Tenant delivers the Construction Documents (as defined in Section 10.05(b)) for such work to Landlord at least five (5) Business
Days’ prior to commencing such work. Without limiting Landlord’s rights hereunder, Landlord shall not be deemed unreasonable for withholding its approval as to any Tenant Work which would require unusual expense to re-adapt the Premises or any portion thereof to normal office use or typical laboratory use upon the termination or expiration of this Lease. In any event, non-structural
cosmetic work such as painting, carpeting and wall coverings (“Cosmetic Work”) shall not require Landlord’s consent or be included in the calculation of the Tenant Work Threshold, and no prior notice to Landlord of such work is
required. Whether or not Landlord’s approval is required, Tenant shall neither propose nor effect any Tenant Work that in Landlord’s reasonable judgment (i) adversely affects any structural component of the Building,
(ii) materially affects any Building System, (iii) affects the exterior or the exterior appearance of the Building or common areas within or around the Building or other property than the Premises, (iv) includes the installation of
equipment that will have an unreasonable acoustic impact on other tenants of the Building when compared to similar equipment in first-class office and laboratory buildings, (v) diminishes the value of the Premises, the Building or the Property,
or (vi) requires any unusual expense to readapt the Premises for use by a future occupant for the Permitted Uses. Any disputes regarding the scope and estimated cost of the work necessary to readapt the Premises for the Permitted Uses shall be
resolved pursuant to Section 16.17. Prior to commencing any Tenant Work affecting air disbursement from ventilation systems serving the Premises, including the installation of Tenant’s exhaust systems, Tenant shall
provide Landlord with a third-party report from a consultant, and in a form, reasonably acceptable to Landlord, showing that such work will not adversely affect the ventilation systems of the Building (or of any other tenant in the Building) and
shall, upon completion of such work, provide Landlord with a certification reasonably satisfactory to Landlord from such consultant confirming that no such adverse effects have resulted from such work. Landlord shall have the right to require Tenant
to provide to Landlord from time to time while Tenant’s Work is being performed, periodic lien waivers in statutory form from Tenant’s Contractor and such subcontractors and suppliers as Landlord may designate from time to time.

  
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 10.05(b) Construction Documents. No Tenant Work, other than Cosmetic Work, shall be
effected except in accordance with complete, coordinated construction drawings and specifications (“Construction Documents”) prepared in accordance with Exhibit H attached hereto. Before commencing any Tenant Work requiring
Landlord’s approval hereunder, Tenant shall obtain Landlord’s prior written approval of the Construction Documents for such work, which approval shall not be unreasonably withheld, conditioned or delayed. Landlord shall be given a
reasonable opportunity to consult with Tenant and review plans for any work under this Lease requiring Landlord’s consent as they are being prepared. The Construction Documents shall be prepared by an architect (“Tenant’s
Architect”) registered in the Commonwealth of Massachusetts and experienced in the construction of tenant space improvements in comparable buildings in the area where the Premises are located and, if the value of such Tenant Work will equal
or exceed the Tenant Work Threshold Amount or will affect any Building System, the identity of Tenant’s Architect (and also engineers if such work will affect any Building System) shall be approved by Landlord in advance, such approval not to
be unreasonably withheld, conditioned or delayed. Tenant shall be solely responsible for the liabilities associated with and expenses of all architectural and engineering services relating to Tenant Work and for the adequacy, accuracy, and
completeness of the Construction Documents even if approved by Landlord (and even if Tenant’s Architect has been otherwise engaged by Landlord in connection with the Base Building Work or the Initial Tenant Work). Construction Documents shall
set forth in detail the requirements for construction of the Tenant Work and shall show all work necessary to complete the Tenant Work, including all cutting, fitting, and patching and all connections to the mechanical, electrical, and plumbing
systems and components of the Building. Submission of the Construction Documents to Landlord for approval shall be deemed a warranty by Tenant that all Tenant Work described in the Construction Documents (i) complies with all applicable Legal
Requirements, (ii) does not materially adversely affect any structural component of the Building, (iii) is compatible with and does not materially adversely affect the Building Systems, (iv) does not affect any property other than the
Premises, (v) conforms to floor loading limits specified by Landlord, and (vi) with respect to all materials, equipment and special designs, processes or products, does not infringe on any patent or other proprietary rights of others. The
Construction Documents shall comply with Landlord’s requirements for the uniform exterior appearance of the Building, including the use of Building standard window blinds and Building standard light fixtures (which Building standard items shall
be consistent with the first-class nature of the Building). Landlord’s approval of Construction Documents shall signify only Landlord’s consent to the Tenant Work shown and shall not result in any responsibility of Landlord concerning
compliance of the Tenant Work with any Legal Requirements, or coordination or compatibility with any component or system of the Building, or the feasibility of constructing the Tenant Work without damage or harm to the Building, all of which shall
be the sole responsibility of Tenant. Landlord hereby represents to Tenant that the Base Building Work performed prior to the date of this Lease complies in all material respects with all applicable Legal Requirements. 

If, as a result of any Tenant Work performed or proposed to be performed by Tenant, Landlord is or will be obligated to comply with any Legal
Requirement (including the Americans With Disabilities Act) which was not previously applicable to the Premises or the Building (or which was previously applicable in a different manner or to a different extent), and such compliance requires
Landlord to make any improvement or alteration to any portion of the Building or the Property, then (i) when Landlord makes such determination prior to the performance of such Tenant Work, as a condition to Landlord’s consent, Landlord
shall have the right to require Tenant to pay to Landlord prior to the performance of such Tenant Work, the entire cost of any improvement or alteration Landlord is obligated to complete by such Legal Requirement, or (ii) when Landlord makes
such determination after such Tenant Work has commenced (regardless of whether or not the same has been completed), Tenant shall pay to Landlord, as Additional Rent, within ten (10) days of demand therefor by Landlord, the entire cost of any
improvement or alteration Landlord is obligated to complete by reason of such Legal Requirement. 
 10.05(c) Performance. The identity
of any person or entity (including any employee or agent of Tenant) performing any Tenant Work (“Tenant Contractor”) requiring Landlord’s approval hereunder shall be subject to Landlord’s prior written approval, which
approval shall not be unreasonably withheld, conditioned or delayed. Once any Tenant Contractor has been approved, the same Tenant Contractor may thereafter be used by Tenant for the same type of work until Landlord notifies Tenant that such Tenant
Contractor is no longer approved. Tenant shall procure at Tenant’s expense all necessary permits and licenses (and shall provide copies thereof to Landlord) before undertaking any Tenant Work, but shall not

  
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take any plans for Tenant Work to any governmental authority for review or approval without Landlord’s prior written authorization in each instance (which prior authorization shall not be
unreasonably withheld, conditioned or delayed). Tenant shall perform (or shall cause Tenant’s Contractor to perform) all Tenant Work at Tenant’s risk, in compliance with the Rules and Regulations and all applicable Legal Requirements and
Insurance Requirements, and in a good and workmanlike manner, employing new materials of good quality and producing a result at least equal in quality to the other parts of the Premises. When any Tenant Work is in progress, Tenant shall cause to be
maintained insurance as described in the Tenant Work Insurance Schedule attached hereto as Exhibit I and such other insurance as may be reasonably required by Landlord covering any additional hazards due to such Tenant Work. If the cost of
any Tenant Work exceeds the Tenant Work Threshold Amount, Tenant shall provide to Landlord such bonds or other assurances of satisfactory completion and payment as Landlord may reasonably require, in each case for the benefit of Landlord. If the
Tenant Work in any instance requires Landlord’s approval hereunder, Tenant shall reimburse Landlord within thirty (30) days of demand, as Additional Rent, for its reasonable third-party out-of-pocket costs of reviewing the proposed Tenant Work and inspecting the performance of such work (as well as all costs imposed upon Landlord by any mortgagee which reviews and/or inspects the same).
During the performance of any Tenant Work, representatives of Tenant and Landlord shall meet periodically (not less frequently than monthly) to review and discuss the progress of the work and the schedule for the performance of the remaining work.

 Each Tenant Contractor shall do nothing to impair any guaranties or warranties applicable to any portion or component of the Building or
the Property, and shall take all steps reasonably necessary to avoid delaying or otherwise interfering with the work of any contractor of Landlord or of any other tenant. Each Tenant Contractor working on the roof of the Building shall coordinate
with Landlord’s roofing contractor, shall comply with its requirements and shall not violate existing roof warranties. Tenant shall indemnify and hold the Indemnitees harmless from any claim, loss or expense based upon injury to persons or
damage to property to the extent arising from the act or omission of Tenant’s Contractor or any subcontractor or supplier of any tier, while on or about the Premises or the Property, except to the extent caused by the negligence or willful
misconduct of Landlord or Landlord’s agents, employees, contractors, and/or invitees. 
 10.05(d) Payment. Tenant shall pay the
entire cost of all Tenant Work so that the Premises, including Tenant’s leasehold, shall always be free of liens for labor or materials; provided, however, that in the event that there is a dispute over whether payment is due and
payable, Tenant may withhold payment so long as it files and records a bond sufficient to discharge any potential lien arising from the dispute or other security acceptable to Landlord and its mortgagees in their reasonable discretion within ten
(10) Business Days after Tenant has notice (from any source) of such dispute. If any such lien is filed that is claimed to be attributable to Tenant or persons acting under Tenant, then Tenant shall promptly (and always within ten
(10) Business Days) discharge the same by payment or filing any necessary bond. In the event that Tenant fails to discharge such lien within the time period set forth above, Landlord shall have the right, but not the obligation, to bond over or
otherwise discharge such lien as further set forth in Section 13.02 of this Lease; provided, however, that no notice or cure period shall apply. In such case Tenant shall pay Landlord’s reasonable costs of
discharging such lien within ten (10) Business Days of demand as Additional Rent. 
 10.05(e) Other. Tenant must schedule and
coordinate all aspects of work with the Building manager or other person or persons designated from time to time by Landlord, and shall make prior arrangements for elevator or temporary hoist use. Landlord shall provide Tenant and all other tenants
requiring the use of freight elevators and temporary hoists with joint access and the parties shall use reasonable efforts to coordinate such joint access to avoid conflicts. If an operating engineer is required by any union regulations, Tenant
shall pay for such engineer. If shutdown of risers and mains for electrical, mechanical or plumbing work is required, such work shall be supervised by Landlord’s representative at Tenant’s cost. If special security arrangements must be
made (e.g., in connection with work outside Normal Business Hours), Tenant shall pay the actual cost of such security. No work shall be performed in Building mechanical or electrical equipment rooms without Landlord’s approval, which approval
shall not be unreasonably withheld, conditioned or delayed, and all such work shall be performed under Landlord’s supervision. Except in case of emergency, at least five (5) days’ prior notice must be given to the Building manager
prior to the proposed shutdown of fire, sprinkler or other alarm systems, and in case of emergency, prompt notice shall be given. In the event that such work unintentionally alerts the Fire or Police Department or any private alarm monitoring
company through an alarm signal, Tenant shall be liable for any fees or charges levied by the Fire or Police Department or any private alarm monitoring company in connection with such alarm except to the extent such alert was caused by Landlord or
Landlord’s agents, employees, invitees or contractors. All demolition, installations, removals or other work that is reasonably likely to inconvenience other tenants of the Property or disturb Property operations must be scheduled with the
Building manager at least five (5) days in advance. 

  
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 Any requirements of any Tenant Contractor for services from Landlord or Landlord’s
Contractor, such as hoisting, electrical or mechanical needs, shall be paid for within thirty (30) days of billing after such costs are incurred, and arranged between such Tenant Contractor and Landlord or Landlord’s contractor. Tenant
shall cause each Tenant Contractor performing work on the Premises to clean up regularly and remove its debris from the Premises and Property. If any Tenant Contractor fails so to clean up, then Landlord may, after giving Tenant at least twenty-four
(24) hours’ prior written notice, cause its contractor to clean up and remove debris, and Tenant shall pay the reasonable out-of-pocket costs of such cleanup
and removal upon demand. 
 Each Tenant Contractor shall take all reasonable steps to assure that any work is carried out without disruption
from labor disputes arising from whatever cause, including disputes concerning union jurisdiction and the affiliation of workers employed by said Tenant Contractor or its subcontractors. Tenant shall be responsible for, and shall reimburse Landlord,
as Additional Rent, for, all actual costs and expenses, including reasonable attorneys’ fees and costs incurred by Landlord in connection with the breach by any Tenant Contractor of such obligations. If Tenant does not promptly resolve any
labor dispute caused by or relating to any Tenant Contractor, Landlord may in its sole discretion request that Tenant remove such Tenant Contractor from the Property, and if such Tenant Contractor is not promptly removed, Landlord may prohibit such
Tenant Contractor from entering the Property. 
 Upon completion of any Tenant Work and as a condition of such completion, Tenant shall give
to Landlord (i) a permanent certificate of occupancy (if one is legally required), and any other final governmental approvals required for such work, (ii) copies of “as built” plans (other than for Cosmetic Work) and all
construction contracts, and (iii) proof of payment for all labor and materials in the form of a final statutory lien waiver from Tenant’s Contractor or such other reasonable evidence as Landlord may require. 

10.05(f) Removal at Conclusion of Term. Except as set forth in the last sentence of this paragraph below, any Tenant Work that is
permanently affixed to the Premises or affixed in a manner so that it cannot be removed without causing other than incidental and repairable damage to the Premises shall become property of the Landlord at the termination of occupancy as provided
herein. If Landlord so notifies Tenant in writing at the time Landlord approves plans for any Tenant Work (or, if Landlord’s consent to the plans is not required, at the time Landlord receives notice of such work), Tenant shall remove such or
all Tenant Work as so specified prior to the conclusion of the Term. Tenant Work that may be removed with only incidental and/or repairable damage, may be removed by Tenant in any case provided such disturbance or damage is restored and repaired so
that the Premises are left in a clean and fully functional condition at least as good as they were in at the commencement of the Term or as they may be put in thereafter, reasonable wear and tear, damage caused by fire, other casualty or taking, and
damage caused by the negligence or willful misconduct of Landlord, Landlord’s agents, employees, or contractors excepted. 
 10.05(g)
Initial Tenant Work. The provisions of this Section 10.05 shall not apply to Initial Tenant Work except to the extent otherwise expressly provided in the Work Letter. 

10.06. Condition upon Termination. At the expiration or earlier termination of the Term, Tenant (and all persons claiming by, through or
under Tenant) shall without the necessity of notice deliver the Premises (including all Initial Tenant Work, none of which shall be removed by Tenant, and all other Tenant Work to the extent provided in Section 10.05(f) of
this Lease) broom-clean, in compliance with the requirements of Section 10.07 and in good order, repair and condition, excepting only damage caused by fire, other casualty, or taking, reasonable wear and tear, and damage
caused by the negligence or willful misconduct of Landlord, Landlord’s agents, employees, or contractors. The Premises shall be surrendered to Landlord free and clear of any mechanic’s liens (or any similar lien related to labor or
materials) or other lien or encumbrance (excluding liens or encumbrances existing as of the date hereof and liens or encumbrances granted by Landlord or related to work performed by or for Landlord) against any part of the Premises, equipment and/or
any Initial Tenant Work or any other Tenant Work to be surrendered with the Premises. As part of such delivery, Tenant shall also provide all keys (or lock combinations, codes, access cards or electronic passes) to the Premises to Landlord; remove
all signs wherever located; and, except as set forth in Section 10.05(f), remove all Tenant’s Property and other personal property whether or not bolted or otherwise attached. As used herein, “Tenant’s
Property” shall mean all trade fixtures, furnishings, equipment, inventory, cabling of any type, and other personal property owned by Tenant or any person acting under Tenant at the Premises. Tenant shall repair all damage that results from
such removal and restore the Premises substantially to a fully functional and tenantable condition (including the filling of all floor and wall holes, the removal of all disconnected wiring back to junction boxes and the replacement of all damaged
ceiling tiles). Any property not so removed shall be deemed abandoned, shall at once become the property of Landlord, and may be disposed of in such manner as Landlord shall see fit; and Tenant shall pay the reasonable cost of removal and disposal
to Landlord upon demand. The provisions of this Section shall survive the expiration or earlier termination of the Term. 

  
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 10.07. Decommissioning of the Premises. Prior to the expiration of this Lease (or
within thirty (30) days after any earlier termination), Tenant shall clean and otherwise decommission all interior surfaces (including floors, walls, ceilings, and counters), piping, supply lines, waste lines, tanks, and plumbing in or serving
the Premises, and all exhaust or other ductwork in or serving the Premises, in each case that has carried, released or otherwise been exposed to any Hazardous Materials, and shall otherwise clean the Premises so as to permit the report hereinafter
called for by this Section 10.07 to be issued. Prior to the expiration of this Lease (or within thirty (30) days after any earlier termination), Tenant, at Tenant’s expense, shall obtain and provide to Landlord a
report addressed to Landlord and Landlord’s designees prepared by a reputable licensed environmental engineer or certified industrial hygienist that is designated by Tenant and acceptable to Landlord in Landlord’s reasonable discretion,
which report shall be based on such person’s inspection of the Premises (including visual inspection, airborne and surface monitoring, and, if Tenant or any Tenant Party at any time stored or used any radioactive materials in the Premises,
Geiger counter evaluation), and shall show: 
 (i) that the Hazardous Materials brought onto the Premises by or for the use
by Tenant or any Tenant Party, if any, existing prior to such decommissioning, have been removed as necessary so that the interior surfaces of the Premises (including floors, walls, ceilings, and counters), piping, supply lines, waste lines, tanks,
and plumbing, and all such exhaust or other ductwork in and/or serving the Premises, may be reused by a subsequent tenant or disposed of in compliance with applicable Environmental Laws without taking any special precautions for Hazardous Materials,
without incurring special costs or undertaking special procedures for demolition, disposal, investigation, assessment, cleaning or removal of Hazardous Materials, and without incurring regulatory compliance requirements or giving notice in
connection with Hazardous Materials; 
 (ii) if Tenant or any Tenant Party at any time stored or used any radioactive
materials in the Premises, that the Premises (and all piping, supply lines, waste lines, tanks, and plumbing, and all exhaust or other ductwork in and/or serving the Premises), have been decommissioned in accordance with the regulations of the U.S.
Nuclear Regulatory Commission and/or the Massachusetts Department of Public Health for the control of radiation, and have accordingly been released for unrestricted use by the Radiation Control Program of the Massachusetts Department of Public
Health for the control of radiation; and 
 (iii) that the Premises may be reoccupied for office or laboratory use,
demolished or renovated without taking any special precautions for Hazardous Materials, without incurring special costs or undertaking special procedures for disposal, investigation, assessment, cleaning or removal of Hazardous Materials, and
without incurring regulatory requirements or giving notice in connection with Hazardous Materials. 
 For purposes of the preceding clauses (i) and
(iii) “special costs” or “special procedures” shall mean costs or procedures, as the case may be, that would not be incurred but for the nature of the Hazardous Materials introduced to the Premises by or for the use by Tenant or
any Tenant Party, as Hazardous Materials instead of non-Hazardous Materials. The report shall include reasonable detail concerning the clean-up locations, the tests run
and the analytic results. 
 In addition, Tenant shall provide to Landlord prior to the expiration of the Term (or within thirty
(30) days after any earlier termination), a copy of its most current chemical waste removal manifest and a certification from Tenant executed by an officer of Tenant that no Hazardous Materials or other potentially dangerous or harmful
chemicals brought onto the Premises by Tenant or any Tenant Party from and after the date that Tenant first took occupancy of the Premises remain in the Premises. 

If Tenant fails to perform its obligations under this Section 10.07, then without limiting any other right or
remedy, Landlord may, on five (5) Business Days’ prior written notice to Tenant, perform such obligations at Tenant’s expense, and Tenant shall within ten (10) days of demand reimburse Landlord, as Additional Rent, for all
reasonable out-of-pocket costs and expenses incurred by Landlord in connection with such work, together with an Administrative Charge, as defined in
Section 13.02. In addition, at Landlord’s election, Landlord may inspect the Premises and/or the Property for Hazardous Materials at Landlord’s cost and expense within sixty (60) days of Tenant’s
surrender of the Premises at the expiration or earlier termination of this Lease. Tenant shall pay for all such costs and expenses incurred by Landlord in connection with such inspection if such inspection reveals that a release or threat of release
of Hazardous Materials exists (a) at the Property as a result of the acts or omission of Tenant, its officers, employees, contractors, and agents, or (b) at the Premises (except to the extent resulting from the acts or omissions of
Landlord or Landlord’s agents, employees or contractors, or occupants of other portions of the Building). 
 The provisions of this
Section 10.07 shall survive the expiration of the Term or the earlier termination of this Lease. 

  
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 ARTICLE 11: DAMAGE OR DESTRUCTION; CONDEMNATION 

11.01. Damage or Destruction of Premises. If the Premises or the Building are damaged in whole or in part by any fire or other casualty
(a “casualty”), Tenant shall immediately give notice thereof to Landlord. Unless this Lease is terminated as provided herein, Landlord, at its own expense (but only to the extent of the insurance proceeds (net of all costs and expenses
incurred in obtaining same) received by Landlord on account thereof), except for any insurance deductibles (which shall be deemed Operating Costs), shall proceed with diligence to repair or cause to be repaired such damage so as to restore the
Premises (including the Initial Tenant Work but excluding any other Tenant Work) to substantially the same condition they were in prior to the casualty, subject to then applicable Legal Requirements. All such repairs made necessary by any act or
omission of Tenant shall be made by Landlord at Tenant’s expense to the extent that the cost of such repairs is not covered by insurance proceeds available therefor (including the payment by Tenant of any applicable deductible amount). Landlord
shall not be liable for delays in the making of any such repairs that are due to government regulation, casualties, strikes, unavailability of labor and materials, delays in obtaining insurance proceeds (provided Landlord files insurance claims with
reasonable diligence), and other causes beyond the reasonable control of Landlord, nor shall Landlord be liable for any inconvenience or annoyance to Tenant or injury to the business of Tenant resulting from delays in repairing such damage. All
repairs to and replacements of Tenant Property and any Tenant Work other than the Initial Tenant Work shall be made by and at the expense of Tenant, which work Tenant shall promptly commence as soon as practicable and thereafter prosecute diligently
to completion. 
 Landlord shall, within sixty (60) days after the occurrence of a casualty, provide Tenant with a good faith estimate
of the time required to repair the damage to the Premises or the Building, as provided herein; if such estimate is for a period of more than two hundred seventy (270) days from the occurrence of the casualty (or during the last twenty-four
(24) months of the Term, for a period of more than ninety (90) days), the Premises shall be deemed “substantially damaged”. If the Premises or the Building are substantially damaged, or if any mortgagee refuses to make available
to Landlord for the purpose of making such repairs a sufficient amount of the insurance proceeds, then in either such case Landlord may elect to terminate this Lease by giving Tenant written notice of such termination within one hundred twenty
(120) days of the date of such casualty. In addition, if the Premises or the Building are substantially damaged through no fault of Tenant or Tenant’s employees, contractors, invitees or agents, then Tenant may terminate this Lease by
giving Landlord written notice of such termination within one hundred twenty (120) days of the date of such casualty. 
 If the
Premises or any part thereof shall have been rendered unfit for use and occupation hereunder by reason of such damage, the Base Rent, or a just and proportionate part thereof, according to the nature and extent to which the Premises shall have been
so rendered unfit, shall be abated from and after the date of such casualty until the Premises (except as to Tenant Property and any Tenant Work other than the Initial Tenant Work) shall have been restored as nearly as practicable to the condition
in which they were immediately prior to such fire or other casualty. Notwithstanding the foregoing, if such casualty was due to the act or omission of Tenant or Tenant’s employees, contractors, invitees or agents, such abatement or reduction
shall be made only if and to the extent of any proceeds of rental interruption insurance actually received by Landlord and allocated to the Premises. 

In the event of any termination, the Term shall expire as though such effective termination date were the date originally stipulated in
Article 1 for the end of the Term and the Base Rent (to the extent not abated as set forth above) and Additional Rent for Operating Costs shall be apportioned as of such date. 

11.02. Eminent Domain. In the event of any condemnation or taking in any manner for public or quasi-public use, which shall be deemed
to include a voluntary conveyance in lieu of a taking (a “taking”) of the whole of the Building, this Lease shall forthwith terminate as of the date when Tenant is required to vacate the Premises. In such event Base Rent and Tenant’s
share of Operating Costs shall be apportioned as of the date of termination. Landlord shall promptly notify Tenant of any written notice received by Landlord from any governmental authority with respect to any condemnation or taking (including said
voluntary conveyance) of the Property or any part thereof. 
 In the event that only a part of the Premises or the Building shall be taken,
then, if such taking is a substantial taking (as hereinafter defined), either Landlord or Tenant may, by delivery of notice in writing to the other within sixty (60) days following the date on which Landlord’s title has been divested by
such authority, terminate this Lease, effective as of the date when Tenant is required to vacate the portion of the Premises so taken. A “substantial taking” shall mean a taking which: requires restoration and repair of the remaining
portion of the Building that cannot in the ordinary course be reasonably expected to be repaired within one hundred eighty (180) days; results in the loss of all reasonable access to the Premises; results in the loss of more than twenty-five
percent (25%) of the rentable floor area of the Premises; or results in the loss of more than ten (10%) percent of the number of parking spaces currently serving the Building and Landlord reasonably determines it is not practical to relocate such
parking within the remaining Property or on other property within the vicinity of the Property. 

  
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 Unless this Lease is terminated as provided herein, Landlord, at its own expense (but only
to the extent of the condemnation proceeds (net of all costs and expenses incurred in obtaining same) received by Landlord on account thereof), shall proceed with diligence to restore the remaining portion of the Premises (including the Initial
Tenant Work) and the necessary portions of the Building as nearly as practicable to the same condition as it was prior to such taking, subject to then applicable Legal Requirements. Landlord shall not be liable for delays in the performance of such
restoration that are due to government regulation, casualties, strikes, unavailability of labor and materials, delays in payment of condemnation proceeds, and other causes beyond the reasonable control of Landlord, nor shall Landlord be liable for
any inconvenience or annoyance to Tenant or injury to the business of Tenant resulting from delays in repairing such damage. All repairs to and replacements of Tenant Property and any Tenant Work other than the Initial Tenant Work shall be made by
and at the expense of Tenant, which work Tenant shall promptly commence as soon as practicable and thereafter prosecute diligently to completion. 

In the event some portion of the rentable floor area of the Premises is taken (other than for temporary use) and this Lease is not terminated,
Base Rent and Tenant’s share of Operating Costs shall be proportionally abated for the remainder of the Term. In the event of any taking of the Premises or any part thereof for temporary use, (i) this Lease shall be and remain unaffected
thereby and Rent shall not abate, and (ii) Tenant shall be entitled to receive for itself such portion or portions of any award made for such use with respect to the period of the taking that is within the Term (and the remainder of such award
shall be paid to Landlord), provided that if such taking shall remain in force at the expiration or earlier termination of this Lease, then Tenant shall pay to Landlord a sum equal to the reasonable cost of performing Tenant’s obligations
hereunder with respect to surrender of the Premises and upon such payment shall be excused from such obligations. 
 Landlord shall have and
hereby reserves and excepts, and Tenant hereby grants and assigns to Landlord, all rights to recover for damages to the Premises, the Building or the Property. Tenant agrees to execute such further instruments of assignment as may be reasonably
requested by Landlord, and to turn over to Landlord any damages that may be recovered in any proceeding or otherwise; and Tenant irrevocably appoints Landlord as its
attorney-in-fact with full power of substitution so to execute and deliver in Tenant’s name, place and stead all such further instruments if Tenant shall fail to do
so after ten (10) days’ notice. Nothing contained herein shall be construed to prevent Tenant from prosecuting in any condemnation proceedings a separate claim for the value of any of Tenant’s leasehold interest and improvements,
Tenant’s personal property, and for relocation and moving expenses and business losses, provided that such action shall not affect the amount of compensation otherwise recoverable by Landlord from the taking authority. 

ARTICLE 12: ASSIGNMENT AND SUBLETTING 

12.01. Landlord’s Consent Required. Except (i) for Related Party Transfers, and (ii) as set forth in this Article, Tenant
shall not directly or indirectly assign this Lease, or sublet or license the Premises or any portion thereof, or advertise the Premises for assignment or subletting, or permit the occupancy of all or any portion of the Premises or the use of any
portion of the Initial Tenant Work by any person other than Tenant, including transfer by mortgage, pledge or other encumbrance (whether of all or any portion of Tenant’s interest under this Lease, or any ownership interest (direct or indirect)
in Tenant, or any portion of the Initial Tenant Work or any equipment, machinery, trade fixture or other property paid for in whole or in part by any portion of Landlord’s Allowance) each of the foregoing actions are collectively referred to as
a “Transfer”), nor advertise the availability of or market the Premises for a Transfer in whole or in part, without obtaining, on each occasion, the prior written consent of Landlord, which consent shall not be unreasonably
withheld, conditioned or delayed, provided that Tenant complies with the provisions of this Article. An assignee, subtenant, licensee, or other occupant is referred to herein as a “Transferee”. It shall be reasonable for Landlord to
withhold consent to a proposed Transfer (other than a Related Party Transfer) if the proposed Transferee does not have a net worth equal to or in excess of that of Tenant at the Date of Lease or immediately prior to the proposed Transfer, whichever
is greater, or if the use proposed to be made of the Premises (or the applicable portion thereof) by the proposed Transferee is not a Permitted Use hereunder. A “Transfer” shall include any transfer of Tenant’s interest in this Lease
by operation of law, the transfer or sale of a controlling interest in Tenant (whether direct or indirect, and whether in one transaction or in a series of related transactions), any “Related Party Transfer” (as defined below), and the
grant of permission or license by Tenant to any other person or entity to use or occupy any portion of the Premises for any period of time or for any purpose whatsoever. Any Transfer shall be subject to this Lease, all of the provisions of which
shall be conditions to such Transfer and be binding on any Transferee. No Transferee shall have any right further to Transfer its interest in the Premises, and nothing herein shall impose any obligation on Landlord with respect to a further
Transfer. For purposes of this Lease, the term “Transfer” shall not include any mortgage, pledge or other encumbrance on or of any equipment, machinery, trade fixture or other property owned or used by Tenant which is not paid for in whole
or in part by any portion of Landlord’s Allowance. 

  
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 12.02. Terms. Tenant shall not offer to make a Transfer (i) to any tenant in the
Building (or any Affiliate of such tenant) if, at the time of Tenant’s intended Transfer, Landlord then has comparable space in the Building available for lease for a comparable term, or (ii) to any person or entity that would be of such
type, character or condition as to be inappropriate as a tenant of a building comparable to the Building. The provisions of this Section 12.02 shall not apply to Related Party Transfers. 

12.03. Related Party Transfers . Tenant may make a Related Party Transfer (as defined below) without the consent of Landlord provided
that Tenant gives Landlord at least ten (10) days’ prior written notice thereof together with evidence reasonably satisfactory to Landlord that the proposed Transfer is a Related Party Transfer and such Related Party Transfer is subject to
all of the other terms and conditions of this Article. A “Related Party Transfer” shall mean one or more of the following: (1) any assignment to (A) a parent which owns (either directly or indirectly) substantially all of
the voting stock of Tenant or otherwise exercises voting control over Tenant, or (B) a subsidiary of Tenant in which Tenant owns (directly or indirectly) substantially all of the voting stock or over which Tenant otherwise exercises voting
control, (C) any subsidiary of Tenant’s parent in which such parent owns (directly or indirectly) substantially all of the voting stock or over which such parent otherwise exercises voting control, or (D) any other Affiliate of
Tenant, or (2) an assignment incident to the sale of all or substantially all of Tenant’s assets, or (3) a statutory merger or consolidation of Tenant with any other entity, provided that in any of the situations described in the
preceding clauses (1)-(3), (a) the person or entity succeeding to Tenant’s interest immediately thereafter (the “Related Party Transferee”) has a net worth equal to or in excess of that of Tenant at the Date of Lease or
immediately prior to the Related Party Transfer, whichever is greater, and (b) such Related Party Transferee agrees in writing, for the benefit of Landlord, to assume all of Tenant’s obligations under this Lease. Related Party Transfers
shall not be subject to the provisions of (i) Section 12.02, (ii) the first sentence of Section 12.04, or (iii) Section 12.05. 

12.04. Procedures. At least thirty (30) days prior to the effective date of any Transfer, Tenant shall give Landlord in writing the
details of the proposed Transfer, including: (i) the name, business, and financial condition (including the most recent annual and quarterly financial statements, in form and content reasonably acceptable to Landlord) of the prospective
Transferee, (ii) a true and complete copy of the proposed instrument containing all of the terms and conditions of such Transfer, (iii) a written agreement of the prospective Transferee, in form and content reasonably acceptable to
Landlord, agreeing with Landlord to perform and observe all of the terms, covenants, and conditions of this Lease undertaken by such Transferee, and (iv) any other information Landlord reasonably requires. Tenant shall pay to Landlord, as
Additional Rent, Landlord’s reasonable attorneys’ fees in reviewing any Transfer. Tenant shall provide Landlord with a true and correct copy of the instrument effecting the Transfer on or before the date that it takes effect, except that
with respect to a Related Party Tenant Transfer, Tenant shall, within fifteen (15) days after the Related Party Transfer, deliver to Landlord evidence of merger or such other evidence as is reasonably satisfactory to Landlord that such Related
Party Transfer has occurred. 
 12.05. Excess Rents. If the consideration, rent, or other amounts payable to Tenant under any
sublease, license, or other occupancy arrangement (collectively, a “Sublease”) or any assignment exceed the sum of (1) Rent and other charges to be paid hereunder (which amounts, in the case of a Sublease, shall be pro-rated based on the floor area intended to be subject to such Sublease), and (2) Tenant’s Expenses (which shall be (a) in the case of an assignment, amortized over the remaining Term of the Lease,
and (b) in the case of a Sublease, (i) pro-rated based on the floor area intended to be subject to such Sublease, and (ii) amortized over the fixed term of the Sublease in question), then Tenant
shall pay to Landlord, as Additional Rent, one-half (1/2) of the amount of such excess when and as received by Tenant. “Tenant’s Expenses” shall mean, collectively, (i) the necessary
and reasonable expenses incurred by Tenant in good faith to third parties in connection with such an assignment or Sublease (as the case may be) on account of brokerage, legal, design, and demising and leasehold improvement costs in the portion of
the Premises affected by, and specifically in connection with, such assignment or Sublease, and (iii) the unamortized out of pocket cost to Tenant of previously constructing Tenant Work in the Premises (or, in the case of a Sublease, in the
portion of the Premises to be subject to such Sublease) and in either case with respect to the Initial Tenant Work, only the portion of the cost thereof paid out of pocket by Tenant, and not the portion of the cost thereof covered by Landlord’s
Allowance pursuant to the Work Letter, shall be included as an “out of pocket cost to Tenant” for purposes of this calculation, with such amortization to be calculated on a straight line basis over the remaining Initial Term of the Lease
as of the date such expense was incurred by Tenant. There shall be included in the calculation to be performed pursuant to the first sentence of this section any lump-sum payment or periodic payments made to
Tenant for the purchase of so-called leasehold improvements, but all lump-sum or periodic payments made to Tenant on account of the leasing or mere use of Tenant’s
equipment by the Transferee under such Sublease or assignment shall be excluded from such calculation. The provisions of this Section 12.05 shall not apply to Related Party Transfers.

  
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 12.06. No Release. Notwithstanding any Transfer and whether or not the same is a
Related Party Transfer or is consented to, the liability of Tenant to Landlord shall remain direct and primary, to the extent that Tenant still exists as a separate entity after a Related Party Transfer. Any Transferee of all or substantially all of
Tenant’s interest in the Premises, including any such Transferee under a Related Party Transfer, shall be jointly and severally liable with Tenant (to the extent that Tenant still exists as a separate entity after a Related Party Transfer) to
Landlord for the performance of all of Tenant’s covenants under this Lease; and such Transferee shall upon written request from Landlord execute and deliver such instruments as Landlord reasonably requests in confirmation thereof (and agrees
that its failure to do so shall be a default). During any period when there exists an Event of Default by Tenant which is then continuing, Tenant hereby irrevocably authorizes Landlord to collect Rent and other charges from any Transferee (and upon
notice from Landlord any Transferee shall pay directly to Landlord) and apply the net amount collected to the Rent and other charges reserved under this Lease. No Transfer shall be deemed a waiver of the provisions of this Section, or the acceptance
of the Transferee as a tenant, or a release of Tenant from direct and primary liability for the performance of all of the covenants of this Lease. The consent by Landlord to any Transfer shall not relieve Tenant or any Transferee from the obligation
of obtaining the express consent of Landlord to any modification of such Transfer or a further Transfer by Tenant or such Transferee. Notwithstanding anything to the contrary in the documents effecting the Transfer, Landlord’s consent shall not
alter in any manner whatsoever the terms of this Lease, to which any Transfer at all times shall be subject and subordinate. The breach by Tenant or any Transferee of any provision of this Article shall be a default for which there is no cure
period. 
 ARTICLE 13: EVENTS OF DEFAULT AND REMEDIES 

13.01. Events of Default. In the event that: 
  

	 	(A)	 Tenant shall default in the payment of any Base Rent, Additional Rent or other sum payable under this Lease,
when and as the same shall become due and payable hereunder, and such default shall continue for a period of five (5) days after Landlord gives Tenant notice that such payment was not paid when due; provided, however, that after Landlord
has given two (2) notices to Tenant of a failure to timely pay a recurring monthly charge (such as Basic Rent, Operating Costs or utility charges, regardless of whether the amount of such charge may vary from month to month), then for a period
of twelve (12) months from the date of such notice Tenant shall not be entitled to any notice of a further default in the payment of any recurring monthly charge (whether of the same or a different monetary obligation of Tenant hereunder) and
Tenant’s failure at any time during such 12-month period to make any such payment within five (5) days after the date on which such payment is due hereunder shall constitute an Event of Default
without the necessity of any notice; or 

  

	 	(B)	 Tenant shall (i) abandon or vacate for not less than three (3) consecutive months all or
substantially all of the Premises, or (ii) make any Transfer in violation of this Lease; or (iii) fail to (a) maintain all insurance as required hereunder, or (b) provide Landlord with the certificates of insurance required
pursuant to Article 7 above, or (c) restore or replenish the amount of the Security Deposit following a draw by Landlord upon the Security Deposit, as required by Article 14 below, or (d) provide Landlord with an estoppel
certificate as required by Section 15.04 below; or 

  

	 	(C)	 Tenant shall file a voluntary petition in bankruptcy or shall be adjudicated a bankrupt or insolvent; or shall
file any petition or answer seeking any reorganization, arrangement, composition, liquidation, dissolution or similar relief under any present or future federal, state or other statute, law or regulation relating to bankruptcy, insolvency or other
relief for debtors; or shall seek, or consent to, or acquiesce in the appointment of any trustee, receiver or liquidator of Tenant; or shall make any general assignment for the benefit of creditors; or 

 

	 	(D)	 any court enters an order, judgment or decree approving a petition filed against Tenant seeking any
reorganization, arrangement, composition, liquidation, dissolution or similar relief under any present or future federal, state or other statute, law or regulation relating to bankruptcy, insolvency or other relief for debtors, or for the
appointment of a receiver, and such order, judgment or decree shall remain unvacated or unstayed for an aggregate of ninety (90) days; or 

  

	 	(E)	 any representation or warranty made by Tenant herein is untrue in any material respect when made; or

  
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	 	(F)	 Tenant shall default in the observance or performance of any of Tenant’s covenants, agreements or
obligations hereunder, other than those referred to in the foregoing clauses (A)-(E), and such default shall not be corrected within the cure period expressly provided in this Lease therefor (and if no cure period is expressly provided, then for
thirty (30) days after notice is given, provided, however that such period shall be reasonably extended in the case of a non-monetary default that cannot be cured within such 30-day period through the use of diligent efforts but only if the default can be cured and Tenant begins such cure within such 30-day period and thereafter diligently
prosecutes such sure continuously to completion); 

 then, and in any such case, Landlord and its agents lawfully may, in addition to any
remedies for any preceding breach, immediately or at any time thereafter without demand or notice and with or without process of law, enter upon any part of the Premises in the name of the whole or mail or deliver a notice of termination of the Term
of this Lease addressed to Tenant at the Premises or any other address herein, and thereby terminate the Term and repossess the Premises as of Landlord’s former estate. Any default by Tenant continuing beyond applicable notice and cure periods
by is referred to herein as an “Event of Default”. Tenant waives any statutory notice to quit and equitable rights in the nature of further cure or redemption, and Tenant agrees that upon Landlord’s termination of this Lease,
Landlord shall be entitled to re-entry and possession in accordance with the terms hereof. Tenant agrees that a notice by Landlord alleging any default shall, at Landlord’s option (the exercise of such
option shall be indicated by the inclusion of the words “notice to quit” in such notice), constitute a statutory notice to quit. If Landlord exercises its option to designate a notice of default hereunder as a statutory notice to quit, any
grace periods provided for herein shall run concurrently with any statutory notice periods. Tenant further agrees that it shall not interpose any counterclaim or set-off in any summary proceeding or in any
action based in whole or in part on non-payment of Rent other than mandatory counterclaims. 
 Upon
such entry or mailing the Term shall terminate, all executory rights of Tenant and all obligations of Landlord will immediately cease, and Landlord may expel Tenant and all persons claiming under Tenant and remove their effects without any trespass
and without prejudice to any remedies for arrears of Rent or prior breach; and Tenant waives all statutory and equitable rights to its leasehold (including rights in the nature of further cure or redemption, if any). If Landlord engages attorneys in
connection with any failure to perform by Tenant hereunder, Tenant shall reimburse Landlord within ten (10) days of demand, as Additional Rent, for the reasonable fees of such attorneys. Without implying that other provisions do not survive,
the provisions of this Article shall survive the Term or earlier termination of this Lease. 
 Rent forgiveness, allowances for (and/or
Landlord expenses in designing and constructing) the Initial Tenant Work to ready the Premises for Tenant’s occupancy and the like, if any, have been agreed to by Landlord as inducements for Tenant faithfully to perform all of its obligations
hereunder for the entire Term. For all purposes, upon the occurrence of any Event of Default, any such inducements shall be deemed void as of the date hereof as though such had never been included, and the unamortized amounts (or value) thereof as
of the date of such Event of Default (based on straight line amortization of such amounts (or value), with interest thereon per annum at the Default Rate, over what would otherwise have constituted the Term of this Lease) will be deemed to be
Additional Rent then immediately due. The foregoing will occur automatically without any further notice by Landlord, whether or not the Term is then or thereafter terminated. 

Subject to the provisions of this Article 13, Tenant shall indemnify Landlord against all loss of Rent and other costs, expenses, loss
and damages that Landlord may incur during what would otherwise have constituted the balance of the Term by reason of the termination of this Lease for Tenant’s Event of Default hereunder. Without limiting the generality of the foregoing,
Tenant shall reimburse Landlord for all expenses incurred by Landlord arising out of such termination, including all costs incurred in collecting amounts due from Tenant under this Lease (including reasonable attorneys’ fees, costs of
litigation and the like); all expenses incurred by Landlord in good faith in attempting to relet the Premises or parts thereof (including advertisements, brokerage commissions, tenant allowances, costs of preparing space, and the like); and all
other expenditures by Landlord arising out of or resulting from the termination. The reimbursement from Tenant shall be due and payable immediately from time to time upon notice from Landlord that an expense has been incurred, without regard to
whether the expense was incurred before or after the termination of this Lease. 

  
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 13.02. Remedies for Default. 

13.02(a) Reletting Expenses Damages. If this Lease is terminated for Tenant’s Event of Default, Tenant covenants, as an additional
cumulative obligation after such termination, to pay on demand by Landlord all of Landlord’s reasonable costs, including reasonable attorneys’ fees and costs, related to Tenant’s default and in collecting amounts due, and all
reasonable expenses in connection with reletting, including tenant inducements to new tenants, brokerage commissions, fees for legal services, expenses of preparing the Premises for reletting and the like, together with an administrative charge of
ten (10%) percent of all the foregoing costs (“Reletting Expenses”). It is agreed that Landlord may (i) relet the Premises or part or parts thereof for a term or terms that may be equal to, less than or exceed the period that
would otherwise have constituted the balance of the Term, and may grant such tenant inducements, including free rent, as Landlord in its sole discretion considers advisable, and (ii) make such alterations to the Premises as Landlord in its sole
discretion considers advisable, and no failure to relet or to collect rent under any reletting shall operate to reduce Tenant’s liability. Except to the extent imposed by applicable law, Landlord shall have no obligation to relet the Premises
or any portion thereof, and any obligation to relet imposed by law will be subject to Landlord’s reasonable objectives of developing its property in a harmonious manner with appropriate mixes of tenants, uses, floor areas, terms and the like.

 13.02(b) Termination Damages. If this Lease is terminated for Tenant’s Event of Default, then unless and until Landlord elects
lump sum liquidated damages described in the next paragraph, Tenant covenants, as an additional, cumulative obligation after any such termination, to pay punctually to Landlord all the sums and perform all of its obligations hereunder at the same
time and in the same manner as if this Lease had not been terminated. In calculating such amounts, Tenant will be credited with the net proceeds of any rent then actually received by Landlord from a re-letting
of the Premises after deducting all Rent and Reletting Expenses that have not then been paid by Tenant, provided that Tenant shall never be entitled to receive any portion of the re-letting proceeds, even if
the same exceed the Rent originally due hereunder. 
 13.02(c) Lump Sum Liquidated Damages. If this Lease is terminated for
Tenant’s Event of Default, Tenant covenants, as an additional, cumulative obligation after any such termination, to pay forthwith to Landlord at Landlord’s election made by written notice at any time after termination, as liquidated
damages, a single lump sum payment equal to the sum of (i) all sums then due and owing from Tenant to Landlord at the time of such election, plus (ii) either, as Landlord elects, (A) the excess of the present value of all of the Rent
reserved for the residue of the Term (with Additional Rent deemed to increase four (4%) percent in each year on a non-compounding basis) over the present value of the aggregate Fair Market Rent and Additional
Rent payable on account of the Premises during such period, which Fair Market Rent shall be reduced by reasonable projections of vacancies and by Landlord’s Reletting Expenses described above to the extent not theretofore paid to Landlord, or
(B) an amount equal to the sum of all of the Rent and other sums due under the Lease with respect to the 12-month period next following the date of termination. The Federal Reserve discount rate (or
equivalent) shall be used in calculating such present values under clause (ii)(A). 
 13.02(d) Remedies Cumulative; Late Performance.
The remedies to which Landlord may resort under this Lease, and all other rights and remedies of Landlord, are cumulative, and any two or more may be exercised at the same time. Nothing in this Lease shall limit the right of Landlord to prove and
obtain in proceedings for bankruptcy or insolvency an amount equal to the maximum allowed by any statute or rule of law in effect at the time; and Tenant agrees that the fair value for occupancy of all or any part of the Premises at all times shall
never be less than the Base Rent and all Additional Rent payable from time to time. Tenant shall also indemnify and hold Landlord harmless in the manner provided elsewhere herein if Landlord shall become or be made a party to any claim or action
(a) instituted by Tenant against any third party, or by any third party against Tenant, or by or against any person claiming by, through or under Tenant; (b) for foreclosure of any lien for labor or material furnished to or for Tenant or
such other person; (c) otherwise arising out of or resulting from any act or transaction of Tenant or such other person; or (d) necessary to protect Landlord’s interest under this Lease in a bankruptcy proceeding, or other proceeding
under Title 11 of the United States Code, as amended. 
 13.02(e) Landlord’s Curing. If Tenant fails to perform any covenant
within the applicable cure period (if any), then Landlord at its option may (without waiving any right or remedy for Tenant’s non-performance) at any time thereafter perform the covenant for the account
of Tenant. Tenant shall upon demand reimburse, as Additional Rent, Landlord’s cost (including reasonable attorneys’ fees) of so performing, together with an administrative charge equal to ten percent (10%) of such cost
(“Administrative Charge”) on demand as Additional Rent. Notwithstanding any other provision concerning cure periods, Landlord may cure any non-performance for the account of Tenant after such
notice to Tenant, if any, as is reasonable under the circumstances if curing prior to the expiration of the applicable cure period is reasonably necessary to prevent likely damage to the Premises or the Property or possible injury to persons, or to
protect Landlord’s interest in the Premises or the Property. 

  
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 ARTICLE 14: SECURITY DEPOSIT 

Upon the execution of this Lease, Tenant shall deposit with Landlord a Letter of Credit as described in this Section (the “Letter of
Credit”), as security for the punctual performance of each and every obligation of Tenant under this Lease. Tenant shall simultaneously deliver to Landlord such documentation as Landlord may reasonably require to demonstrate that
Tenant’s obligation to the issuer of the Letter of Credit is a secured obligation. In no event shall the Security Deposit be deemed to be a prepayment of Rent nor shall it be considered a measure of liquidated damages. 

The Letter of Credit shall be an irrevocable standby letter of credit, in form and content and issued by Silicon Valley Bank or another
commercial bank satisfactory to Landlord in its sole discretion (Landlord agreeing not to unreasonably withhold, delay or condition its approval of another commercial bank with a credit rating at that time from Moody’s Investors Service or
Standard & Poor’s equal to or better than that of Silicon Valley Bank as of the date of this Lease), which Letter of Credit shall provide that it may be drawn upon in Boston, Massachusetts (i) in part or in whole, upon the
presentation of a sight draft accompanied by a certificate signed by a representative of Landlord, setting forth the amount due to Landlord by reason of the occurrence of an Event of Default by Tenant hereunder, or (ii) in whole, upon the
presentation of a sight draft accompanied by a certificate signed by a representative of Landlord, stating that (a) such Letter of Credit will expire within thirty (30) days of such certificate, and (b) Tenant has not deposited a
substitute Letter of Credit in the form, amount and issued by a bank as required by this Section. Any payment drawn by Landlord under the Letter of Credit pursuant to clause (ii) of the preceding sentence shall be held by Landlord as a cash
Security Deposit (“Cash Security”) pursuant to the provisions of this Article. Landlord may commingle any Cash Security with Landlord’s other funds, and no interest shall be due thereon. The Letter of Credit shall remain in
full force and effect for a period of at least one hundred twenty (120) days beyond the expiration of the Term. Tenant shall deposit the original Letter of Credit with Landlord and shall keep the Letter of Credit in full force and in compliance
with the provisions of this Lease throughout the Term. 
 Landlord may apply the Security Deposit towards any Event of Default by Tenant
and/or damages sustained by Landlord as a result thereof. In the event that Landlord so draws upon and applies or retains any portion or all of the proceeds of the Letter of Credit, or so applies all or any portion of the Cash Security, Tenant shall
pay to Landlord, as Additional Rent, the amount so expended by Landlord (or shall deliver an amendment to the Letter of Credit increasing the amount of the Letter of Credit by the amount so drawn by Landlord) within three (3) Business Days of
notice given by Landlord so that at all times (subject to the 3-Business Day grace period herein referenced) Landlord shall be entitled to draw down upon the full aggregate amount of the Letter of Credit or
hold the full Cash Security, or some combination thereof. Notwithstanding anything contained in this Lease to the contrary, any failure of Tenant to restore any amount drawn under the Letter of Credit or expended from the Cash Security within the
time and manner specified in this Section shall immediately constitute an Event of Default hereunder (without the necessity of any additional notice or the passage of any additional time) and entitle Landlord to immediately draw down the Letter of
Credit then in force or effect and Landlord shall retain such cash amounts as a Security Deposit pursuant to the provisions of this Section. Tenant shall be solely responsible for the payment of all costs associated with obtaining, replacing (as
necessary), transferring, extending and maintaining the Letter of Credit in accordance with the terms of this Section. The application of all or any part of the Security Deposit to any Event of Default of Tenant under this Lease shall not deprive
Landlord of any other rights or remedies Landlord may have, nor shall such application by Landlord constitute a waiver by Landlord. In addition, in the event of a termination based upon an Event of Default of Tenant under this Lease, or a rejection
of the Lease pursuant to the provisions of the Federal Bankruptcy Code, Landlord shall have the right to apply the Security Deposit (from time to time, if necessary) to cover up to the full amount of damages and other amounts due from Tenant to
Landlord under the Lease. Any amounts so applied shall, at Landlord’s election, be applied first to any unpaid Rent and other charges which were due prior to the filing of the petition for protection under the Federal Bankruptcy Code. 

Landlord shall assign the Security Deposit to any purchaser of the Building, and thereafter Landlord shall have no further responsibility
therefor. Upon request of Landlord or any such purchaser of the Building, Tenant shall, at its expense, cooperate with Landlord in obtaining an amendment to or replacement of any Letter of Credit which Landlord is then holding so that the amended or
new Letter of Credit reflects the name of the new owner of the Building. 
 Within one hundred twenty (120) days after the expiration
or earlier termination of the Term, Landlord shall inspect the Premises, make such draw upon the Letter of Credit or apply all or any portion of the Cash Security as may be required to cure any Event of Default by Tenant hereunder or to make payment
on account of damages suffered by Landlord, and, if no Event of Default is then continuing, Landlord shall redeliver the original Letter of Credit (as may have previously been drawn on by Tenant) or pay the balance of the Cash Security, as the case
may be, to Tenant. 

  
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 Notwithstanding the foregoing, provided that: (i) no Event of Default on the part of
Tenant has occurred prior to the applicable “Reduction Date” (as hereinafter defined), and no such Event of Default is continuing as of such Reduction Date, and (ii) (a) with respect to the first Reduction Date, Tenant demonstrates to
Landlord’s reasonable satisfaction that at all times during the twelve (12) months prior to such Reduction Date Tenant has held unrestricted cash in an amount equal to at least three (3) times the then-applicable amount of Base Rent
for the next twelve (12) months commencing on such Reduction Date, or (b) with respect to the second Reduction Date, Tenant demonstrates to Landlord’s reasonable satisfaction that at all times during the twelve (12) months prior
to such Reduction Date Tenant has held unrestricted cash in an amount equal to at least two (2) times the then-applicable amount of Base Rent for the next twelve (12) months commencing on such Reduction Date; and (iii) the Lease is
then in full force and effect, Landlord agrees to accept a reduction in the amount of the Letter of Credit which it is then holding so as to cause the total Security Deposit to be reduced as of each Reduction Date to the amount shown in the
following schedule: 
  

			
	 Reduction Date
	  	 New Reduced Amount of Security Deposit

	1st day of 37th month after	  	9 months of Base Rent and Operating Costs
	Rent Commencement Date	  	at then-current rates as of the Reduction Date
		
	1st day of 61st month after	  	6 months of Base Rent and Operating Costs
	Rent Commencement Date	  	at then-current rates as of the Reduction Date

 Any reduction in a Letter of Credit held by Landlord as the Security Deposit shall be accomplished by Tenant
providing Landlord with a substitute Letter of Credit in the reduced amount in exchange for the existing Letter of Credit(s) which Landlord is then holding, or by an amendment to the existing Letter of Credit(s) then held by Landlord, in form and
substance reasonably acceptable to Landlord, which is accepted by Landlord in writing. If Tenant does not satisfy the requirements for a reduction in the amount of the Letter of Credit on a Reduction Date as specified above, then Tenant shall have
the right to extend such Reduction Date for up to four (4) months by written notice given to Landlord prior to such Reduction Date in order to enable Tenant to satisfy such requirements as of such extended Reduction Date; failing which Tenant
shall be deemed to have irrevocably forfeited its right to the corresponding reduction in the amount of the Letter of Credit (but such a forfeiture of Tenant’s right to the first reduction in the amount of the Letter of Credit shall not affect
Tenant’s right to receive the second reduction in the amount of the Letter of Credit if the requirements of this paragraph are timely satisfied with respect to such second reduction). 

ARTICLE 15: PROTECTION OF LENDERS/GROUND LANDLORD 

15.01. Subordination and Superiority of Lease. Tenant agrees that this Lease and the rights of Tenant hereunder will be subject and
subordinate to the lien of the holder of any existing or future mortgage, and to the rights of any lessor under any ground or improvements lease of the Building (all mortgages and ground or improvements leases of any priority are collectively
referred to in this Lease as “mortgage”, and the holder or lessor thereof from time to time as a “mortgagee”), and to all advances and interest thereunder and all modifications, renewals, extensions, replacements and
consolidations thereof, provided that such mortgagee executes and delivers to Tenant a subordination, non-disturbance and attornment agreement in the form attached hereto as Exhibit J or in such other
form as such mortgagee may request and as is reasonably acceptable to Tenant. Upon such attornment, this Lease shall continue in full force and effect as a direct lease between the mortgagee and Tenant upon all of the terms, conditions and covenants
as are set forth in this Lease, except that the mortgagee shall not be (i) liable in any way to Tenant for any act or omission, neglect or default on the part of Landlord under this Lease except to the extent to which Tenant previously notified
such mortgagee in writing of such default and such default continues during such mortgagee’s period of ownership; (ii) responsible for any monies held by or on deposit with Landlord to the credit of Tenant unless received by the holder (it
being agreed that Landlord shall remain responsible for such monies until delivered to such holder); (iii) subject to any counterclaim or setoff that theretofore accrued to Tenant against Landlord; (iv) bound by any amendment or modification of
this Lease subsequent to such mortgage or by any previous prepayment of Rent for more than one (1) month which was not approved in writing by the mortgagee (except that such approval shall not be required with respect to any amendment to this
Lease that is ratifying the exercise by Tenant of any rights that Tenant has under this Lease (e.g., rights of extension and expansion)); (v) liable to Tenant beyond the mortgagee’s interest in the Property; or (vi) responsible for the
performance of any work to be done by Landlord under this Lease to render the Premises ready for occupancy by Tenant. Tenant agrees that any present or future mortgagee (or any holder of a ground or improvements lease) may at its option unilaterally
elect to subordinate, in whole or in part and by instrument in form and substance satisfactory to such mortgagee alone, the lien of its mortgage (or the priority of its lease) to this Lease effective upon either notice from such holder to Tenant in
the same fashion as notices from Landlord to Tenant are to be given hereunder or by the recording in the appropriate registry of deeds of an instrument in which such holder subordinates its rights under such mortgage or lease.

  
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 Tenant agrees that this Lease shall survive the merger of estates of ground (or
improvements) lessor and lessee. Until a mortgagee forecloses Landlord’s equity of redemption (or terminates or succeeds to a new lease in the case of a ground or improvements lease), no mortgagee shall be liable for failure to perform any of
Landlord’s obligations (and such mortgagee shall thereafter be liable only after it succeeds to and holds Landlord’s interest and then only as limited herein). 

In the event Tenant alleges that Landlord is in default under any of Landlord’s obligations under this Lease, Tenant agrees to give the
holder of any mortgage, by registered mail, a copy of any notice of default that is served upon Landlord, provided that prior to such notice, Tenant has been notified in writing (whether by way of notice of an assignment of lease, request to execute
an estoppel letter, or otherwise) of the address of any such holder. Tenant further agrees that if Landlord shall have failed to cure such default within the time provided in Section 16.02 below or such additional time as
may be provided in such notice to Landlord, such holder shall have thirty (30) days after the last date on which Landlord could have cured such default within which such holder will be permitted to cure such default. If such default cannot be
cured within such 30-day period, then such holder shall have such additional time as may be necessary to cure such default, if within such 30-day period such holder has
commenced and is diligently pursuing the remedies necessary to effect such cure (including, but not limited to, commencement of foreclosure proceedings, if necessary, to effect such cure). The agreements in this Lease with respect to the rights and
powers of a mortgagee constitute a continuing offer to any person that may be accepted by taking a mortgage (or entering into a ground or improvements lease) of the Premises. 

If, in connection with obtaining financing for the Property or any portion thereof, a bank, insurance company, pension trust or other
institutional lender shall request reasonable modifications to this Lease as a condition to such financing, Tenant will not unreasonably withhold, delay or condition its consent thereto, provided that such modifications do not materially increase
the obligations of Tenant hereunder or materially adversely affect the leasehold interest hereby created. 
 15.02. Rent Assignment.
If at any time and from time to time, Landlord assigns this Lease or the Rent payable hereunder to the holder of any mortgage on the Premises or the Property, or to any other party for the purpose of securing financing (the holder of any such
mortgage and any other such financing party are referred to herein as the “Financing Party”), whether such assignment is conditional in nature or otherwise, the following provisions shall apply: 

 

	 	(A)	 Except as set forth in clause (B) below, such assignment to the Financing Party shall not be deemed an
assumption by the Financing Party of any obligations of Landlord hereunder unless such Financing Party shall, by written notice to Tenant specifically otherwise, elect; 

 

	 	(B)	 The Financing Party shall be treated as having assumed Landlord’s obligations hereunder (subject to
Section 15.01) only upon foreclosure of its mortgage (or voluntary conveyance by deed in lieu thereof); and 

  

	 	(C)	 Subject to Section 15.01 and Section 15.02, the Financing
Party shall be responsible for only such breaches under the Lease by Landlord that occur during the period of ownership by the Financing Party after such foreclosure (or by conveyance by deed in lieu thereof) as aforesaid, except to the extent to
which Tenant previously notified the Financing Party in writing of such breach on the part of Landlord and such breach continues during such Financing Party’s period of ownership. 

Tenant hereby agrees to enter into such reasonable agreements or instruments as may, from time to time, be requested by Landlord in confirmation of the
foregoing. 
 15.03. Other Instruments. The provisions of this Article shall be self-operative; nevertheless, Tenant agrees to
execute, acknowledge and deliver any subordination, attornment or priority agreements or other instruments conforming to the provisions of this Lease from time to time reasonably requested by Landlord or any mortgagee or prospective mortgagee.
Tenant hereby irrevocably constitutes and appoints Landlord or any such mortgagee, acting singly, Tenant’s attorney-in-fact to execute and deliver any such
certificate or instrument for, on behalf and in the name of Tenant, but only if Tenant fails to execute, acknowledge and deliver any such certificate or instrument within fifteen (15) days after Landlord or such mortgagee has made written
request therefor. Without limitation, where Tenant in this Lease indemnifies or otherwise covenants for the benefit of mortgagees, such agreements are for the benefit of mortgagees as third-party beneficiaries; and at the request of Landlord, Tenant
from time to time will confirm such matters directly with such mortgagee. 

  
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 15.04. Estoppel Certificates. Within ten (10) Business Days after the written
request of Landlord, Tenant shall execute, acknowledge and deliver to Landlord a written statement in the form attached hereto as Exhibit K or in such other form as may be reasonably requested by Landlord, certifying (i) that none of the
terms or provisions of this Lease have been changed (or if they have been changed, stating how); (ii) that this Lease has not been canceled or terminated and is in full force and effect; (iii) the last date of payment of Base Rent and other
charges and the time period covered; (iv) to the best of Tenant’s knowledge, that Landlord is not in default under this Lease (or if in default, describing it in reasonable detail); and (v) such other information with respect to
Tenant as Landlord may reasonably request or which any prospective purchaser or encumbrancer of the Property may reasonably require. Landlord may deliver any such statement by Tenant to any prospective purchaser or encumbrancer, which parties may
rely conclusively upon such statement as true and correct. If Tenant does not deliver such statement to Landlord within such 10-Business Day period, Landlord, and any such prospective purchaser or
encumbrancer, may conclusively presume and rely upon the following facts: (i) that the terms and provisions of this Lease have not been changed except as represented by Landlord; (ii) that this Lease has not been canceled or terminated and
is in full force and effect, except as otherwise represented by Landlord; (iii) that not more than one (1) month’s Base Rent or other charges have been paid in advance; and (iv) that Landlord is not in default under this Lease.
In such event, Tenant shall be estopped from denying the truth of such facts. 
 Within ten (10) Business Days after the written
request of Tenant, Landlord shall execute, acknowledge and deliver to Tenant a written statement in such form as may be reasonably requested by Tenant, certifying (i) that none of the terms or provisions of this Lease have been changed (or if
they have been changed, stating how); (ii) that this Lease has not been canceled or terminated and is in full force and effect; (iii) the last date of payment of Base Rent and other charges and the time period covered; (iv) to the best of
Landlord’s knowledge, that Tenant is not in default under this Lease (or if in default, describing it in reasonable detail); and (v) such other information with respect to Landlord as Tenant may reasonably request or which any prospective
encumbrancer of the Tenant’s equipment or personal property in accordance with the provisions of Section 12.01 may reasonably require. Tenant may deliver any such statement by Landlord to any such prospective
encumbrancer, which parties may rely conclusively upon such statement as true and correct. 
 15.05. Financial Condition. Tenant,
within ten (10) Business Days after request from Landlord from time to time, but in no event more than twice per 12-month period, shall deliver to Landlord Tenant’s annual audited financial
statements for the latest available two (2) fiscal years, including the most recent fiscal year prior to Landlord’s request, and quarterly financial statements certified in writing by an officer of Tenant. Landlord may deliver such
financial statements to its mortgagees and lenders and prospective mortgagees, lenders, and purchasers. Tenant represents and warrants to Landlord that each such financial statement shall be true and accurate as of the date of such statements.
Except for publicly available information, financial statements shall be kept confidential, and Landlord and any parties to whom Landlord provides such statements shall enter into reasonable confidentiality agreements with Tenant, in form reasonably
acceptable to both Landlord and Tenant, prior to Tenant’s delivery of such financial statements. 
 ARTICLE 16: MISCELLANEOUS PROVISIONS 

16.01. Landlord’s Consent Fees. In addition to fees and expenses in connection with Tenant Work as described in
Section 10.05 above, Tenant shall pay Landlord’s reasonable out of pocket fees and expenses, including legal, engineering and other consultants’ fees and expenses, incurred in connection with Tenant’s request
for Landlord’s consent under Article 12 or in connection with any other request by Tenant for Landlord’s consent or approval under this Lease. 

16.02. Landlord’s Default. Landlord shall in no event be in default in the performance of any of Landlord’s obligations under
this Lease unless and until Landlord shall have failed to perform such obligation within thirty (30) days after notice by Tenant to Landlord (“Tenant’s Default Notice”) specifying the manner in which Landlord has failed to
perform any such obligation (provided that if correction of any such matter reasonably requires longer than thirty (30) days and Landlord so notifies Tenant within thirty (30) days after such Tenant’s Default Notice is given, Landlord
shall be allowed such longer period, but only if cure is begun within such 30-day period and thereafter diligently prosecuted to completion). In the event of any default by Landlord hereunder, Tenant shall
have no right to perform such Landlord obligation and recover from Landlord any costs so incurred, or (except as expressly otherwise provided in Section 6.03 above) to abate or withhold Rent, but Tenant shall have the
right, in the event of a default by Landlord hereunder, to commence and to prosecute an independent proceeding against Landlord for the recovery of damages or for equitable relief. This Lease shall be construed as though Landlord’s and
Tenant’s covenants contained herein are independent and not dependent, and Tenant hereby waives the benefit of any statute or judicial law to the contrary. In no event shall Landlord ever be liable to Tenant for any indirect, special,
consequential, or punitive damages. 

  
 47 

 16.03. Quiet Enjoyment. Landlord agrees that, so long as no Event of Default has
occurred and is then continuing under this Lease, Tenant shall peaceably and quietly hold, occupy and enjoy the Premises during the Term of this Lease without disturbance by Landlord or by any person claiming through or under Landlord, subject to
the terms of this Lease and any encumbrances of record. 
 16.04. Interpretation. In any provision relating to the conduct, acts or
omissions of Tenant, the term “Tenant” includes Tenant’s agents, employees, contractors, invitees, or successors. In any provision relating to the conduct, acts or omissions of Landlord, the term “Landlord”
includes Landlord’s agents, employees, contractors, invitees, or successors; provided, however, that neither the foregoing nor any reference in this Lease to “invitees” of Landlord shall be construed so as to include Tenant
or any other tenant or occupant of any portion of the Property or any of their respective employees, agents, contractors or invitees. 

16.05. Notices. All notices, requests and other communications required under this Lease shall be in writing, addressed as specified in
Article 1, and shall (unless otherwise expressly provided in this Lease) be (i) personally delivered, or (ii) sent by certified mail, return receipt requested, postage prepaid, or (iii) delivered by a national overnight
delivery service that maintains delivery records. Any notice so addressed shall be effective upon the earlier of (a) actual receipt, or (b) first tender for delivery by the United States Postal Service or a national overnight courier
(provided that such first tender occurs on a Business Day), or (c) on the third Business Day following the day of mailing if so mailed by certified mail, return receipt requested. Either party may change its notice address upon written notice
to the other party. Whenever oral notice is expressly permitted to be provided by either party pursuant to the provisions of this Lease, such notice shall only be valid and effective if such party uses all reasonable efforts to provide confirmatory
written notice to the other party within twenty-four (24) hours of the giving of such oral notice. 
 16.06. No Recordation.
Tenant shall not record this Lease or any portion(s) hereof, and immediately upon any such recording this Lease shall automatically (and without the necessity of any notice from or action by Landlord) terminate. Notwithstanding the foregoing,
Landlord and Tenant agree to execute herewith a Notice of Lease in the form attached hereto as Exhibit M, which shall be recorded with the appropriate Registry of Deeds, and agree to execute, upon termination of this Lease for
whatever cause, a Notice of Termination of Lease in recordable form for recording with said Registry of Deeds. 
 16.07. Corporate
Authority. Each of Tenant and Landlord warrant and represent to the other that (a) such party is duly organized, validly existing and in good standing under the laws of the jurisdiction in which such entity was organized; (b) such
party has the authority to own its property and to carry on its business as contemplated under this Lease; (c) such party has duly executed and delivered this Lease; and (d) the execution, delivery and performance by such party of this
Lease (i) are within the powers of such party, (ii) have been duly authorized by all requisite action, (iii) will not violate any provision of law or any order of any court or agency of government, or any agreement or other instrument
to which such party is a party or by which it or any of its property is bound, and (iv) will not result in the imposition of any lien or charge on any of such party’s property, except by the provisions of this Lease. Each party agrees that
breach of the foregoing warranties and representations shall at the other party’s election be a default under this Lease for which there shall be no cure. These warranties and representations shall survive the expiration of the Term or the
earlier termination of this Lease. Upon execution of this Lease, Tenant shall provide a board resolution or other entity vote authorizing the execution of this Lease on behalf of Tenant and identifying the person authorized to execute this Lease on
behalf of Tenant, together with a clerk’s or secretary’s certificate indicating that such authorized person has in fact executed this Lease. 

16.08. Joint and Several Liability. If more than one party signs this Lease as Tenant, they shall be jointly and severally liable for
all obligations of Tenant. 
 16.09. Force Majeure. If either party is delayed or hindered in or prevented from the performance of any
act required under this Lease to be performed by such party by reason of (i) strikes, lockouts, or labor disputes not attributable to the failure of the party claiming the benefit of a delay due to “Force Majeure” or any of its
contractors (of any tier) to perform their obligations under any applicable labor contract or law; (ii) inability to obtain labor or materials, or reasonable substitutes therefor; (iii) acts of God, governmental action, condemnation, civil
commotion, terrorism, riots, insurrection, war, fire, or other casualty; (iv) trouble in obtaining fuel, electricity, water, sewer, or telecommunication services or supplies from sources from which they are usually obtained, provided the party
experiencing such trouble shall have used reasonable efforts to procure alternative sources; or (v) other conditions similar to those hereinabove enumerated beyond the reasonable control of the party obligated to perform (collectively,
“Force Majeure”), then performance of such act shall be excused for the period of the delay, and the period for the performance of any such 

  
 48 

 
act shall be extended for a period equivalent to the period of such delay. Subject to the provisions of the last sentence of this Section, in case either party is prevented or delayed from
diligent construction of improvements, making any repairs, alterations or improvements, or furnishing any services or performing any other covenant or duty to be performed on the part of such party by reason of any cause reasonably beyond such
party’s control, then notwithstanding any contrary provision of this Lease, such party shall not be liable to the other party therefor nor shall Tenant be entitled to any abatement or reduction of Rent by reason thereof, nor shall the same give
rise to a claim in Tenant’s favor that such failure constitutes actual or constructive, total or partial, eviction from the Premises. In order to claim the benefit of a delay due to “Force Majeure”, the party experiencing such event
or circumstance must (a) notify the other party within a reasonable time period after such delay commences, and (b) use all reasonable and diligent efforts to minimize the duration of such delay and the effect of the delay upon the
progress of construction of its respective work as described in this Work Letter. Nothing in this Section 16.09 shall excuse Tenant’s failure to make payments under this Lease when due. 

16.10. No Warranties; Limitation on Landlord’s Liability. 

16.10(a) No Warranties. Landlord and Tenant expressly agree that there are and shall be no implied warranties of merchantability,
habitability, suitability, fitness for a particular purpose or of any other kind arising out of this Lease, and there are no warranties which extend beyond those expressly set forth in this Lease. 

16.10(b) Limitation On Landlord’s Liability. Tenant agrees that Landlord shall be liable only for breaches of its covenants
occurring while it is owner of the Property; provided, however, that if Landlord from time to time is lessee of the ground or improvements constituting the Building, then Landlord’s period of ownership of the Property shall be deemed to
mean only that period while Landlord holds such leasehold interest. Upon any sale or transfer of the Building, the transferor Landlord (including any mortgagee) shall be relieved of any liability or obligation thereafter arising and Tenant shall
look solely to the transferee Landlord as aforesaid for satisfaction of such liability or obligation except for defaults by Landlord prior to such transfer (for which the transferor Landlord shall remain liable). Tenant and each person acting under
Tenant agrees to look solely to Landlord’s interest from time to time in the Property for satisfaction of any claim against Landlord. No owner, trustee, beneficiary, partner, member, manager, officer, director, agent, or employee of Landlord
(or of any mortgagee or any lender or ground or improvements lessor) nor any person acting under any of them shall ever be personally or individually liable to Tenant or any person claiming under or through Tenant for or on account of any default by
Landlord or failure by Landlord to perform any of its obligations hereunder, or for or on account of any amount or obligations that may be or become due under or in connection with this Lease or the Premises; nor shall it or they ever be answerable
or liable in any equitable judicial proceeding or order beyond the extent of their interest in the Property. No deficit capital account of any member or partner of Landlord shall be deemed to be a liability of such member or partner or an asset of
Landlord. Any lien obtained to enforce any judgment against Landlord shall be subject and subordinate to any mortgage encumbering the Property. In no event shall Landlord or Tenant (or any such persons) ever be liable to the other party, or anyone
claiming through or on behalf of such party, for any special, indirect, punitive or consequential damages, including lost profits or revenues, except as otherwise provided in Section 3.02 with respect to a holdover by Tenant. 

16.11. No Brokers. Landlord and Tenant represent and warrant to each other that the parties named in Article 1 are the only
agents, brokers, finders or other parties with whom such party has dealt who may be entitled to any commission or fee with respect to this Lease or the Premises or the Property. Landlord shall compensate Landlord’s Broker and Tenant’s
Broker pursuant to a separate agreement between Landlord and such Brokers. Landlord and Tenant agree to indemnify and hold the other harmless from any claim, demand, cost or liability, including reasonable attorneys’ fees and expenses, asserted
by any party other than the parties named in Article 1 based upon dealings of that party with the indemnifying party. The provisions of this Section shall survive the expiration of the Term or the earlier termination of this Lease. 

16.12. No Waiver; Accord and Satisfaction. No consent by Landlord or Tenant to any act or omission that otherwise would be a default
shall be construed to permit other similar acts or omissions. Neither party’s failure to seek redress for violation or to insist upon the strict performance of any covenant, nor the receipt by Landlord of Rent with knowledge of any breach of
covenant, shall be deemed a consent to or waiver of such breach. No breach of covenant shall be implied to have been waived unless such is in writing, signed by the party benefiting from such covenant and delivered to the other party. No acceptance
by Landlord of a lesser sum than the Rent due shall be deemed to be other than on account of the earliest installment of such Rent; nor shall any endorsement or statement on any check or in any letter accompanying any check or payment be deemed an
accord and satisfaction; and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such installment or pursue any other right or remedy. The acceptance by Landlord of any Rent following the
giving of any default and/or termination notice shall not be deemed a waiver of such notice. Tenant shall not interpose any counterclaim or counterclaims in a summary proceeding or in any action based on
non-payment of Rent except to the extent that by failing to do so, Tenant will irrevocably lose the right to assert such claim in an independent action. 

  
 49 

 16.13. Applicable Law and Construction. This Lease may be executed in counterparts,
shall be construed as a sealed instrument, and shall be governed exclusively by the provisions hereof and by the laws of the state where the Property is located without regard to principles of choice of law or conflicts of law. A facsimile or
electronic signature affixed to this Lease shall be sufficient to prove the execution by a party. The covenants of Landlord and Tenant are independent, and such covenants shall be construed as such in accordance with the laws of The Commonwealth of
Massachusetts. If any provision of this Lease or the application thereof to any person or circumstance is for any reason held to be invalid, the remainder of this Lease (or the remainder of such provision) and the application thereof to other
persons or circumstances shall not be affected thereby. Other than contemporaneous instruments executed and delivered of even date, if any, this Lease contains all of the agreements between Landlord and Tenant relating in any way to the Premises and
supersedes all prior agreements and dealings between them. There are no oral agreements between Landlord and Tenant relating to this Lease or the Premises. This Lease may be amended only by instrument in writing executed and delivered by both
Landlord and Tenant. The provisions of this Lease shall bind Landlord and Tenant and their respective successors and assigns, and shall inure to the benefit of Landlord and its successors and assigns and of Tenant and its permitted successors and
assigns, subject to Article 12. The titles are for convenience only and shall not be considered a part of this Lease. This Lease shall not be construed more strictly against one party than against the other merely by virtue of the fact that
it may have been prepared primarily by counsel for one of the parties, it being recognized that both Landlord and Tenant have contributed substantially and materially to the preparation of this Lease. If Tenant is granted any extension or other
option, to be effective the exercise (and notice thereof) shall be unconditional; and if Tenant purports to condition the exercise of any option or to vary its terms in any manner, then the option granted shall be void and the purported exercise
shall be ineffective. Time is of the essence of this Lease and each of its provisions. The enumeration of specific examples of a general provision shall not be construed as a limitation of the general provision, and the term “including”
shall be deemed to mean “including, without limitation”. As used in this Lease, the term “Business Day” shall mean any day other than a Saturday, Sunday, or day on which commercial banks in Boston, Massachusetts are authorized or
required by law to remain closed. Unless a party’s approval or consent is required by the express terms of this Lease to not be unreasonably withheld, conditioned or delayed, such approval or consent may be withheld in the party’s sole
discretion. The submission of a form of this Lease or any summary of its terms shall not constitute an offer by Landlord to Tenant; but a leasehold shall only be created and the parties bound when this Lease is executed and delivered by both
Landlord and Tenant and approved by the holder of any mortgage of the Premises having the right to approve this Lease. Nothing herein shall be construed as creating the relationship between Landlord and Tenant of principal and agent or of partners
or joint venturers or any relationship other than landlord and tenant. This Lease and all consents, notices, approvals and all other related documents may be reproduced by any party by any electronic means or by facsimile, photographic, microfilm,
microfiche or other reproduction process and the originals may be destroyed; and each party agrees that any reproductions shall be as admissible in evidence in any judicial or administrative proceeding as the original itself (whether or not the
original is in existence and whether or not reproduction was made in the regular course of business), and that any further reproduction of such reproduction shall likewise be admissible. If any payment in the nature of interest provided for in this
Lease shall exceed the maximum interest permitted under controlling law, as established by final judgment of a court, then such interest shall instead be at the maximum permitted interest rate as established by such judgment. 

16.14. Waiver of Trial by Jury. LANDLORD AND TENANT HEREBY WAIVE TRIAL BY JURY IN ANY ACTION TO WHICH THEY ARE PARTIES ARISING OUT OF OR
RELATING TO THIS LEASE, THE PREMISES OR THE PROPERTY. 
 16.15. No Representations or Inducements. In entering into this Lease Tenant
acknowledges that Tenant is not relying on any representations, agreements, or promises of Landlord, or any inducements offered by Landlord to Tenant, not expressly set forth in this Lease. 

16.16. No Surrender. No act or thing done by Landlord shall be deemed an acceptance of a surrender of the Premises, and no agreement to
accept such surrender shall be valid, unless in writing signed by Landlord. No employee of Landlord or of Landlord’s agents shall have any power to accept the keys of the Premises prior to the termination of this Lease. The delivery of keys to
any employee of Landlord or of Landlord’s agents shall not operate as a termination of the Lease or a surrender of the Premises. In the event that Tenant at any time desires to have Landlord underlet the Premises for Tenant’s account,
Landlord or Landlord’s agents are authorized to receive the keys or other access devices for such purposes upon written notice from Tenant without releasing Tenant from any of the obligations under this Lease, and Tenant hereby relieves
Landlord of any liability for loss of or damage to any of Tenant’s effects in connection with such underletting. 

  
 50 

 16.17. Arbitration. All disputes between the parties specifically referencing this
Section 16.17 shall be resolved in accordance with this Section 16.17 except (i) Landlord shall have all of its rights and remedies at law or in equity in the event of a default by Tenant,
(ii) Landlord shall have the right to obtain possession of the Premises by any lawful means following a valid termination of this Lease, and (iii) any arbitration decision under this Section 16.17 shall be
enforceable in accordance with applicable law in any court of proper jurisdiction. 
 16.17(a) Initial Construction Disputes. If the
dispute is with respect to matters relating to the Base Building Work or Initial Tenant Work (“Initial Construction Disputes”), the dispute shall initially be submitted by either party to the Landlord Representative and the Tenant
Representative for resolution. The initial representatives of the parties shall be as follows, until a party gives written notice to the other parties that it is replacing its Representative: 

 

			
	 Landlord Representative:
	  	 Tenant Representative:

	Mark A. Deschenes	  	John Athanasopoulos
		
		  	Andrea Armstrong

 The Landlord and Tenant Representatives shall meet one or more times to attempt to resolve such dispute within the 5-Business Day period following the date that such dispute is submitted to them. If, after such meeting(s), the parties have been unable to resolve such dispute, then such dispute shall be resolved as set forth in
Section 16.17(b). 
 16.17(b) Arbitration Procedures. Either party may give written notice of the dispute
requesting resolution under this Section and submit a reasonably detailed written statement of the position and reasons therefor with such notice. The other party will, within ten (10) days ((five (5) days if an Initial Construction
Dispute) of receiving such written statement, submit to the party initiating the dispute resolution its own detailed written statement of the position and reasons therefor. The president of Tenant and Mark A. Deschenes, on behalf of Landlord (or
such other persons as Landlord or Tenant may designate by written notice to the other), shall meet at the earliest mutually acceptable time and place, but in any case within thirty (30) days (ten (10) days if an Initial Construction
Dispute) of the date of the response statement to attempt to resolve the dispute. If the matter has not been resolved within thirty (30) days (ten (10) days if an Initial Construction Dispute) of the date of the response statement, then
either party may initiate arbitration of such controversy by written notice to the other (the “Arbitration Notice”). The arbitration shall be held before a single arbitrator. The parties shall endeavor to agree upon and name the arbitrator
within the 15-day period following the giving of the Arbitration Notice. If the parties fail timely to agree upon and name the arbitrator, then unless the parties agree in writing to another procedure for
designating the arbitrator, either party may by written notice given to the other and to the Boston office of the American Arbitration Association request that the arbitrator be promptly chosen by the Boston office of the American Arbitration
Association. The arbitrator shall commence the arbitration hearing within ten (10) days after appointment, shall complete the arbitration hearing within thirty (30) days after the date the arbitration hearing commenced, and shall render a
written arbitration decision within forty (40)    days after the arbitration hearing commenced, which time periods may be extended by written agreement of the parties or by the arbitrator for good cause, except that any
arbitration of Initial Construction Disputes shall be conducted on an expedited basis and shall be concluded, with a decision issued, no later than two (2) weeks after the date that such dispute was submitted for arbitration. The arbitration
shall be conducted in accordance with then existing expedited procedures under the commercial arbitration rules of the American Arbitration Association; however, to the extent any provision of this paragraph is inconsistent with such procedures, the
provisions of this paragraph shall govern. The decision of the arbitrator shall be final and binding upon the parties and judgment upon the decision rendered by the arbitrator may be entered in any court having jurisdiction thereof. The parties
shall equally share and pay the costs of the arbitrator. Each party shall be afforded a reasonable opportunity to take discovery of the other prior to the commencement of such arbitration consistent with the expedited dispute resolution timetable
set forth in this Section 16.17(b); provided, however, that each party shall be limited to a maximum of twelve (12) deposition hours each. Notwithstanding the foregoing or anything herein to the contrary, the dispute
resolution provisions of this Section shall not apply to a dispute, claim or controversy in which: (i) a party claiming in good faith a breach of any provision of this Lease by the other party seeks immediate equitable relief from a court of
competent jurisdiction to enable the instituting party to prevent irreparable harm (alleged to arise from the alleged breach) pending agreed resolution or a grant of arbitral relief; or (ii) any claim by one party against the other party arises
out of the subject matter of any court litigation or proceeding commenced by any third party against one party in which the other party is an indispensable party or third party defendant; or (iii) any claim is asserted with respect to which a
third party, which is not bound and will not upon request of a party, agree to arbitrate, is an indispensable or necessary party. 

  
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 16.18. Patriot Act. Notwithstanding any other provision contained in this Lease to
the contrary, Tenant shall not knowingly transfer or permit the transfer of any legal or beneficial interest in Tenant to, or assign, sublease or otherwise Transfer all or any portion of its interest under this Lease or in all or any portion of the
Premises to, or enter into any sublease to, any of the following: 
 (a) any person or entity (or any person or entity whose operations are
directed or controlled by a person or entity) that has been convicted of or has pleaded guilty in a criminal proceeding to a felony or that is an on-going target of a grand jury investigation convened pursuant
to applicable statutes concerning organized crime; 
 (b) any entity organized in or controlled from a country, the activities with respect
to which are regulated or controlled pursuant to the following United States laws and the regulations or executive orders promulgated thereunder: (1) the Trading with the Enemy Act of 1917, 50 U.S.C. App. §1, et seq., as amended;
(2) the International Emergency Economic Powers Act of 1976, 50 U.S.C. §1701, et seq., as amended; or (3) the Anti-Terrorism and Arms Export Amendments Act of 1989, codified at Section 6(j) of the Export Administration Act
of 1979, 50 U.S.C. App. §2405W, as amended; or 
 (c) any person or entity with whom Landlord is restricted from doing business under
either (1) Executive Order No. 13224 on Terrorist Financing (effective September 24, 2001 (as amended or supplemented from time to time, the “Executive Order”), or (2) the Uniting and Strengthening America by
Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Public Law 10756; as amended, from time to time, the “Patriot Act”), or (3) the regulations of the United States Department of the Treasury
Office of Foreign Assets Control (including those Persons named on the list of “Specially Designated Nationals and Blocked Persons” as modified from time to time), or other governmental action; or 

(d) any Affiliate of any of the persons or entities described in the preceding paragraphs (a), (b) or (c). 

Tenant shall, simultaneously with its execution and delivery of this Lease, deliver to Landlord a certification stating that, to the best of Tenant’s
knowledge, neither Tenant nor any of its constituent partners, investors, beneficiaries or Affiliates, are in violation of any Legal Requirements relating to terrorism or money laundering, including the Executive Order and the Patriot Act and that
neither Tenant, nor its constituent partners, investors, beneficiaries or Affiliates, are listed on the United States Department of the Treasury Office of Foreign Assets Control list of “Specially Designated Nationals and Blocked Persons”
as modified from time to time, and that none of them is otherwise subject to the provisions of the Executive Order or the Patriot Act, or any rules or regulations promulgated thereunder. Thereafter, Tenant shall from time to time, within ten
(10) days after request by Landlord, deliver to Landlord a certification stating that, to the best of Tenant’s knowledge, neither Tenant nor any Transferee, nor any of their respective constituent partners, investors, beneficiaries or
Affiliates, are in violation of any Legal Requirements relating to terrorism or money laundering, including the Executive Order and the Patriot Act and that neither Tenant nor any Transferee, nor any of their respective constituent partners,
investors, beneficiaries or Affiliates, are listed on the United States Department of the Treasury Office of Foreign Assets Control list of “Specially Designated Nationals and Blocked Persons” as modified from time to time, and that none
of them is otherwise subject to the provisions of the Executive Order or the Patriot Act, or any rules or regulations promulgated thereunder. As used in this Lease, the term “Affiliate” shall mean, with respect to any specific
person or entity, any other person or entity which, directly or indirectly, controls or is controlled by or is under common control with such first-mentioned person or entity. For the purposes of this definition, “control” (including, with
correlative meanings, the terms “controlled by” and “under common control with”), as used with respect to any entity, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the
management and policies of such entity, whether through the ownership of voting stock or by contract or otherwise. 
 (the next page is the
signature page) 

  
 52 

 Executed to take effect as a sealed instrument on the Date of Lease first set forth above.

  

			
	LANDLORD:
	
	480 ARSENAL GROUP LLC,
	a Massachusetts limited liability company
		
	By:	 	 /s/ William P. McQuillan

		 	Name: William P. McQuillan
		 	Title:   Manager
	
	TENANT:
	
	 C4 THERAPEUTICS, INC.,

a Delaware corporation

		
	By:	 	 /s/ Marc Cohen

		 	Marc Cohen,
		 	Executive Chairman

  
 53 

 Schedule 1 

INDEX OF DEFINED TERMS 
  

			
	 TERM
	  	 SECTION

	Additional Rent	  	Section 4.02(a)
	Administrative Charge	  	Section 13.02(e)
	Affiliate	  	Section 16.18
	Agreements	  	Section 2.01(g)
	Annual Operating Statement	  	Section 4.02(a)
	Base Building Plans and Specifications	  	Exhibit C
	Base Building Work	  	Exhibit C
	Base Rent	  	Article 1
	Building	  	Article 1
	Building Holidays	  	Exhibit E
	Building Systems	  	Section 10.05(a)
	Business Day	  	Section 16.13
	Cash Security	  	Article 14
	Construction Documents	  	Section 10.05(b)
	Cosmetic Work	  	Section 10.05(a)
	CPI	  	Section 3.03(c)
	CPI Adjustment	  	Section 3.03(c)
	Date of Lease	  	Article 1
	Default Rate	  	Section 4.04
	Delivery Date	  	Exhibit C
	Environmental Incidents	  	Section 9.04
	Environmental Law	  	Section 9.04
	Estimated Delivery Date	  	Article 1
	Event of Default	  	Section 13.01
	Extension Notice	  	Section 3.03(a)
	Extension Term	  	Section 3.03(a)
	Fair Market Rent	  	Section 3.03(d)
	Financing Party	  	Section 15.02
	Force Majeure	  	Section 16.09
	Guarantor	  	Article 1
	H3 Room	  	Section 2.01(f)
	Hazardous Materials	  	Section 9.04
	Indemnitees	  	Section 9.02
	Initial Tenant Work	  	Exhibit C
	Initial Term	  	Article 1
	Insurance Requirements	  	Section 9.08
	Landlord	  	Article 1
	Landlord’s Allowance	  	Exhibit C
	Landlord’s Broker	  	Article 1
	Landlord’s Fair Market Rent Notice	  	Section 3.03(d)
	Late Penalty Date	  	Exhibit C
	Lease Year	  	Article 1
	Legal Requirement	  	Section 9.03
	Letter of Credit	  	Article 14
	Limited Landlord Services	  	Section 4.02(b)

			
	Material Services Failure	  	Section 6.03
	Measurement Standard	  	Section 2.01(d)
	Mortgage	  	Section 15.01
	Mortgagee	  	Section 15.01
	MSF Notice	  	Section 6.03
	Normal Business Hours	  	Exhibit E
	Operating Costs	  	Section 4.02(a)
	Operating Expenses	  	Section 8.01
	Original Address of Landlord	  	Article 1
	Original Address of Tenant	  	Article 1
	Parking Allotment	  	Section 2.01(f)
	Parking Facilities	  	Section 2.01(f)
	Parking Garage	  	Section 2.01(f)
	Permitted Uses	  	Article 1
	Premises	  	Article 1
	Prime Rate	  	Section 4.04
	Property	  	Article 1
	Real Estate Professional	  	Section 3.03(d)
	Regular Elevator Service Hours	  	Exhibit E
	Related Party Transfer	  	Section 12.03
	Related Party Transferee	  	Section 12.03
	Reletting Expenses	  	Section 13.02(a)
	Rent	  	Section 4.02(a)
	Restoration Areas	  	Section 11.01
	Rules and Regulations	  	Section 9.07
	Security Deposit	  	Article 1
	Sublease	  	Section 12.05
	Substantial Completion	  	Exhibit C
	Substantial Completion Date	  	Exhibit C
	Taxes	  	Section 5.02
	Tenant	  	Article 1
	Tenant Contractor	  	Section 10.05(c)
	Tenant Delays	  	Exhibit C
	Tenant Parties	  	Section 9.02
	Tenant Work	  	Section 10.05(a)
	Tenant Work Threshold Amount	  	Section 10.05(a)
	Tenant’s Architect	  	Section 10.05(b)
	Tenant’s Broker	  	Article 1
	Tenant’s Default Notice	  	Section 16.02
	Tenant’s Expenses	  	Section 12.05
	Tenant’s H3 Space	  	Section 2.01(f)
	Tenant’s Pro Rata Share	  	Section 4.06
	Tenant’s Property	  	Section 10.06
	Term	  	Article 1
	Term Commencement Date	  	Article 1
	Termination Date	  	Article 1
	Transfer	  	Section 12.01
	Transferee	  	Section 12.01
	Utility Service Provider	  	Section 6.01
	Utility Services	  	Section 6.01
	Work Letter	  	Section 3.01

 EXHIBIT A TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

PLAN OF THE PROPERTY 

[See attached pages] 
 Omitted.

 EXHIBIT B TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

BUILDING FLOOR PLAN SHOWING THE PREMISES 

[See attached page] 
 Omitted.

 EXHIBIT C TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

WORK LETTER 
 [See
attached pages] 
 Omitted. 

 EXHIBIT C-1 

LIST OF BASE BUILDING PLANS AND SPECIFICATIONS 

[see attached pages] 

Omitted. 

 EXHIBIT C-2 

TENANT’S INITIAL TEST FIT PLAN 

[see attached pages] 

Omitted. 

 EXHIBIT C-3 

LAB SHELL SPECIFICATIONS 

TENANT LANDLORD MATRIX OF RESPONSIBILITY 

[see attached pages} 

Omitted. 

 EXHIBIT C-4 

PRELIMINARY WORK SCHEDULE 

[see attached pages] 

Omitted. 

 EXHIBIT D TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

INTENTIONALLY DELETED 

 EXHIBIT E TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

CLEANING SPECIFICATION FOR COMMON AREAS AND LANDLORD SERVICES 

[See attached pages] 
 Omitted.

 EXHIBIT E 

CLEANING SPECIFICATIONS FOR COMMON AREAS AND LANDLORD SERVICES 

Omitted. 

 EXHIBIT F TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

SHUTTLE SERVICE 

[See attached pages] 
 Omitted.

 EXHIBIT G TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

RULES AND REGULATIONS 

[See attached pages] 
 Omitted.

 EXHIBIT H TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

CONSTRUCTION DOCUMENT REQUIREMENTS 

[See attached pages] 
 Omitted.

 EXHIBIT I TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

TENANT WORK INSURANCE SCHEDULE 

[See attached pages] 
 Omitted.

 EXHIBIT J TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

FORM OF SNDA 
 [See
attached pages] 
 Omitted. 

 EXHIBIT K TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

FORM OF ESTOPPEL CERTIFICATE 

[See attached pages] 
 Omitted.

 EXHIBIT L TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

EXTERIOR SIGNAGE 

[See attached page] 
 Omitted.

 EXHIBIT M TO LEASE 

BY 480 ARSENAL GROUP LLC TO C4 THERAPEUTICS, INC. 

FORM OF NOTICE OF LEASE 

[See attached pages] 
 Omitted.

  
 - 13 - 

 AMENDMENT TO LEASE 

THIS AMENDMENT TO LEASE (“Amendment”) is made as of August 2, 2018 by and between 480 Arsenal Group LLC, a Massachusetts
limited liability company (“Landlord”), and C4 Therapeutics, Inc., a Delaware corporation (“Tenant”). 

WHEREAS, Landlord and Tenant entered into a Lease dated as of July 5, 2017 (the “Lease”), pursuant to which Landlord leased to
Tenant certain premises situated at 490 Arsenal Way, Watertown, Massachusetts, all as more particularly described in the Lease; and 

WHEREAS, Landlord and Tenant have agreed to modify the provisions of the Lease relating to the “Parking Allotment” (as defined in
the Lease) as set forth in this Amendment. 
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as follows: 
 1. All capitalized terms used in this Amendment which
are defined in the Lease and not otherwise defined herein shall have the same meaning herein as in the Lease. 
 2. Exhibit A, Plan of
the Property, is hereby amended by deleting said Exhibit in its entirety and substituting therefor the two pages attached hereto as Exhibit A. 

3. Article 1, Basic Terms, is hereby amended by deleting therefrom the term “Parking Allotment” and its corresponding
definition in their entirety, and substituting therefor the following: 
  

			
	“Parking Allotment:	  	Parking spaces at a ratio of 2.9 parking spaces per 1,000 rentable square feet in the Premises (initially, 132 parking spaces), including twelve (12) reserved covered spaces initially located as shown on Exhibit A
attached hereto. See Section 2.01(g).”

 4. Section 2.01(f)(iv) is hereby amended by deleting said Section in its entirety and substituting therefor the
following: 
 “(iv) In addition, Landlord shall make available to Tenant, for the exclusive use by Tenant, in the location shown as
“C4 Dedicated Inert Gas Tank Storage Pad” on Exhibit A attached hereto, exterior space for the installation of tanks to accommodate the storage of bulk nitrogen and carbon dioxide.” 

5. Section 2.01(g), Parking, is hereby amended by deleting from clause (iii) thereof the phrase “up to ten (1 0) designated
parking spaces” and replacing it with the phrase “up to twelve (12) designated parking spaces”. 

  
 - 14 - 

 6. Except as specifically amended hereby, the Lease shall remain unchanged and shall be in
full force and effect, enforceable in accordance with its terms. In the event of any conflict between the provisions of the Lease and the provisions of this Amendment, the provisions of this Amendment shall govern and control. 

7. This Amendment shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns, and may not
be modified, amended or cancelled except by a written instrument executed by the parties hereto or their respective successors or assigns. 

8. Landlord and Tenant each hereby represents and warrants to the other party that it has the power and authority to execute and deliver this
Amendment, and that the person executing this Amendment on its behalf has been authorized to do so. 
 Executed as a sealed instrument as of
the date first set forth above. 
  

			
	LANDLORD:
	
	 480 ARSENAL GROUP LLC,

a Massachusetts limited liability company

		
	By:	 	 /s/ William P. McQuillan

		 	Name: William P. McQuillan
		 	Title: Manager
	
	TENANT:
	
	 C4 THERAPEUTICS, INC.,

a Delaware corporation

		
	By:	 	 DocuSigned by:

/s/ Andy Phillips 

		 	Name: Andy Phillips
		 	Title:   President and CEO

  
 - 15 - 

 EXHIBIT A 

PLAN OF THE PROPERTY 

[see attached plans] 

Omitted. 

  
 - 16 - 

 SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (“Second Amendment”) is made as of August 22, 2018 by and between 480 Arsenal Group LLC,
a Massachusetts limited liability company (“Landlord”), and C4 Therapeutics, Inc., a Delaware corporation (“Tenant”). 

WHEREAS, Landlord and Tenant entered into a Lease dated as of July 5, 2017, and an Amendment to Lease dated as of August 2, 2018
(collectively, the “Lease”), pursuant to which Landlord leased to Tenant certain premises situated at 490 Arsenal Way, Watertown, Massachusetts, all as more particularly described in the Lease; 

WHEREAS, Tenant has agreed to relinquish its rights to use the existing restrooms on the second floor of the Building adjacent to the
Premises, in return for which Landlord has agreed to construct, at its sole cost and expense, a restroom and shower area for Tenant’s exclusive use which shall be incorporated into Tenant’s Premises; and 

WHEREAS, Landlord and Tenant agree that it is their mutual intent that this modification to the Building and the Premises not materially
affect the total annual amount of Annual Base Rent payable by Tenant as set forth in the Lease; and 
 WHEREAS, Landlord and Tenant have
agreed to modify the provisions of the Lease as set forth in this Second Amendment to accomplish the foregoing. 
 NOW, THEREFORE, for good
and valuable consideration; the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as follows: 

1. All capitalized terms used in this Second Amendment which are defined in the Lease and not otherwise defined herein shall have the same
meaning herein as in the Lease. 
 2. Exhibit B, Building Floor Plan Showing the Premises, is hereby amended by deleting said
Exhibit in its entirety and substituting therefor the Exhibit B attached hereto. 
 3. Article 1, Premises, is hereby amended
by deleting therefrom the definition of the term “Premises” in its entirety, and substituting therefor the following: 
  

			
	“Premises:	  	A total rentable area of 45,400 rentable square feet, consisting of 463 rentable square feet on the first floor of the West Wing of the Building and 44,937 rentable square feet on the second floor of the West Wing of the Building,
as shown on Exhibit B attached hereto, as measured in accordance with the provisions of Section 2.01(e).”

 4. Article 1, Tenant’s Pro Rata Share, is hereby amended by deleting therefrom the figure
“24.62%” and substituting therefor the figure “24.54%”. 

  
 - 17 - 

 5. Article 1, Base Rent: Initial Term, is hereby amended by deleting therefrom the
table as it appears in the Lease under said definition and substituting therefor the table attached as Schedule 1 to this Second Amendment. 

6. Section 4.06, Tenant’s Pro Rata Share, is hereby amended by deleting therefrom the figure “24.62%” and substituting
therefor the figure “24.54%”. 
 7. Exhibit C, Work Letter, Section A.4, Landlord’s Allowance, is hereby amended
by deleting therefrom the first sentence as it appears in the Lease and substituting therefor the following: 
 “An
amount not to exceed Five Million Nine Hundred Twenty-Two Thousand Six Hundred Seventy ($5,922,670.00) Dollars, to be paid by Landlord towards the cost of design and construction of the Initial Tenant Work,
which amount shall be paid in the manner provided in this Work Letter.” 
 8. Exhibit C, Work Letter, Section C.4, Payment of
Costs for Initial Tenant Work; Landlord’s Allowance, is hereby amended by deleting therefrom the phrase “(up to a total of Four Hundred Fifty-Five Thousand Five Hundred Ninety ($455,590.00) Dollars)” and substituting therefor the
phrase “(up to a total of Four Hundred Fifty-Four Thousand 
 ($454,000.00) Dollars)”. 

9. Except as specifically amended hereby, the Lease shall remain unchanged and shall be in full force and effect, enforceable in accordance
with its terms. In the event of any conflict between the provisions of the Lease and the provisions of this Second Amendment, the provisions of this Second Amendment shall govern and control. 

10. This Second Amendment shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns, and
may not be modified, amended or cancelled except by a written instrument executed by the parties hereto or their respective successors or assigns. 

11. Landlord and Tenant each hereby represents and warrants to the other party that it has the power and authority to execute and deliver this
Second Amendment, and that the person executing this Second Amendment on its behalf has been authorized to do so. 
 12. This Second
Amendment may be executed in counterparts, each of which shall be deemed an original and all such counterparts shall constitute one and the same instrument. A facsimile or electronic signature affixed to this Second Amendment shall be valid as if
affixed to a hard copy hereof in ink. 
 (no further text; signatures appear on the next page) 

  
 - 18 - 

 Executed as a sealed instrument as of the date first set forth above. 

 

			
	LANDLORD:
	
	 480 ARSENAL GROUP LLC,

a Massachusetts limited liability company

		
	By:	 	 /s/ William McQuillan

		 	Name: William McQuillan
		 	Title:   Manager
	
	TENANT:
	
	 C4 THERAPEUTICS, INC.,

a Delaware corporation

		
	By:	 	 /s/ Andrew J. Phillips

		 	Name: Andrew J. Phillips
		 	Title:   President and CEO

  
 - 19 - 

 EXHIBIT B 

BUILDING FLOOR PLAN SHOWING THE PREMISES 

[see attached plan} 

Omitted. 

  
 - 20 - 

 SCHEDULE 1 

TABLE OF ANNUAL BASE RENT FOR THE INITIAL TERM 
  

													
	 Period
	  	Annual Base
Rent	 	  	Monthly Base Rent	 	  	Annual Base Rent Amount	 
	 Rent Commencement Date to 12/31/2019
	  	$	47.16	 	  	$	178,439.42	 	  	$	2,141,273.00	 
	 1/1/2020-12/31/2020
	  	$	48.58	 	  	$	183,792.60	 	  	$	2,205,511.19	 
	 1/1/2021-12/31/2021
	  	$	50.03	 	  	$	189,297.65	 	  	$	2,271,571.74	 
	 1/1/2022-12/31/2022
	  	$	51.54	 	  	$	194,992.52	 	  	$	2,339,910.24	 
	 1/1/2023-12/31/2023
	  	$	53.09	 	  	$	200,839.26	 	  	$	2,410,071.11	 
	 1/1/2024-12/31/2024
	  	$	54.68	 	  	$	206,875.83	 	  	$	2,482,509.91	 
	 1/1/2025-12/31/2025
	  	$	56.32	 	  	$	213,064.26	 	  	$	2,556,771.08	 
	 1/1/2026-12/31/2026
	  	$	58.00	 	  	$	219,442.52	 	  	$	2,633,310.20	 
	 1/1/2027-12/31/2027
	  	$	59.74	 	  	$	226,010.61	 	  	$	2,712,127.27	 
	 1/1/2028-Termination
	  	$	61.53	 	  	$	232,806.49	 	  	$	2,793,677.88

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