Document:

Employment Agreement, by and between the Registrant and Mona Haynes

 Exhibit 10.8 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT
AGREEMENT (the “Agreement”) is made as of this 7th day of February, 2008, by and between Targanta Therapeutics Corporation, (the “Company”), and Mona Haynes
(“Employee”) (collectively, the “Parties”). 
 WHEREAS, the Company
wishes to employ Employee and to assure itself of the continued services of Employee on the terms set forth herein; 
 WHEREAS, Employee wishes to be so employed under the terms set forth herein; 
 NOW,
THEREFORE, in consideration of the mutual promises and covenants contained herein, it is hereby agreed by and between the Parties hereto as follows: 
 1. EMPLOYMENT. The Company will employ Employee and Employee shall serve the Company in the capacity of Chief Commercial
Officer (“CCO”). The Employee’s employment with the Company shall commence on March 3, 2008 (the “Commencement Date”). 
 2. AT-WILL EMPLOYMENT. It is understood and agreed by the Parties that this Agreement does not contain any promise or representation concerning the duration
of Employee’s employment with the Company. Employee specifically acknowledges that her employment with the Company is at-will and except as otherwise prohibited by law, may be altered or terminated by either Employee or the Company at any time,
with or without Cause (as defined below) and with or without notice. The nature, terms or conditions of Employee’s employment with the Company cannot be changed by any oral representation, custom, habit or practice. In addition, that the rate
of salary, any bonuses, paid time off, other compensation, or vesting schedules are stated in units of years or months or weeks does not alter the at-will nature of the employment, and does not mean and should not be interpreted to mean that
Employee is guaranteed employment to the end of any period of time or for any period of time. In the event of conflict between this disclaimer and any other statement, oral or written, present or future, concerning terms and conditions of
employment, the at-will relationship confirmed by this disclaimer shall control. This at-will status cannot be altered except in a writing signed by Employee and approved by the Board of Directors of the Company (the “Board of
Directors”). 
 3. DUTIES. Employee shall render exclusive, full-time services to the Company as its
CCO. Employee shall report to the Company’s Chief Executive Officer. Employee shall perform services under this Agreement primarily at the office of the Company to be located in the Commonwealth of Massachusetts (the “Primary
Location”), and from time to time at such other locations (including Indianapolis) as is necessary to perform the duties of CCO under this Agreement. Subject to the terms of this Agreement, Employee’s responsibilities, working
conditions and duties may be changed, added to, diminished or eliminated during her employment at the sole discretion of the Board of Directors. During Employee’s employment with the Company she shall devote her reasonable best efforts and her
full business time, skill and attention to the performance of her duties on behalf of the Company. 

 4. POLICIES AND PROCEDURES. Employee agrees
that she is subject to and will comply with the policies and procedures of the Company as such policies and procedures may be modified, added to or eliminated from time to time at the sole discretion of the Company, except to the extent any such
policy or procedure specifically conflicts with the express terms of this Agreement. Employee further agrees and acknowledges that any written or oral policies and procedures of the Company do not constitute contracts between the Company and
Employee. 
 5. BASE SALARY. For all services rendered and to be rendered hereunder, the Company
agrees to pay to the Employee, and the Employee agrees to accept a salary of $275,000 per annum (“Base Salary”), which salary will be paid periodically in accordance with normal Company payroll practices and shall be subject to such
deductions and withholdings as the Company is required to make pursuant to law, or by further agreement with the Employee. Employee’s salary shall be subject to annual review and discretionary adjustment by the Board of Directors, which
discretion shall be exercised reasonably. 
 6. STOCK OPTIONS. In connection with Employee’s
commencement of employment by the Company, and no later than the next regularly-scheduled meeting of the Board of Directors, the Company will grant Employee options to purchase 143,000 shares of the Company’s common stock, such options to be
granted at the then-current fair market value of the common stock as determined by the Board of Directors (the “Options”). The terms, conditions and limitations of the Options will be set forth in the Company’s 2007 Stock
Option and Incentive Plan (the “Plan”) and in the standard form of notice of stock option grant and stock option agreement to be approved by the Board of Directors and to be entered into by Employee, such terms and conditions to
include provisions providing that the Options shall vest quarterly in arrears over four years, commencing on the Commencement Date (such that the first 8,937 shares shall vest on June 3, 2008), subject to acceleration in certain circumstances
as further described below. Employee shall be eligible to receive future grants of equity incentives as determined by the Board of Directors (or the compensation committee thereof) in its sole discretion. 
 7. BONUS. Employee may be eligible to receive an annual performance bonus of up to 25% of her Base Salary (subject to
employment taxes, withholding and deductions) for each year of this Agreement (pro rated for the partial year commencing on the date of this Agreement), based upon Employee’s achievements of certain milestones and performance objectives to be
mutually agreed upon by the Board of Directors and the Employee (the “Bonus”). Except as expressly provided otherwise herein, Employee must remain employed by the Company throughout the applicable bonus year in order to be eligible
for any Bonus. The Board of Directors, in its sole discretion, which shall be exercised reasonably, shall determine the extent to which Employee has achieved the performance targets upon which Employee’s Bonus is based, and the amount of Bonus
to be paid to Employee, if any. Bonuses are not earned until they are approved in writing by the Board of Directors. 
 8.
OTHER BENEFITS. While employed by the Company as provided herein: 
 (a)
Employee Benefits. Employee shall be entitled to all benefits to which other executive officers of the Company are entitled, on terms comparable thereto, 

 
including, without limitation, participation in pension and profit sharing plans, 401(k) plan, group insurance policies and plans, medical, health, vision,
and disability insurance policies and plans, and the like, which benefits may be maintained by the Company for the benefit of its executives. The Company reserves the right to alter and amend the benefits received by Employee from time to time at
the Company’s discretion. 
 (b) Expense Reimbursement. Employee shall receive, against presentation of
proper receipts and vouchers, reimbursement for direct and reasonable out-of-pocket expenses incurred by her in connection with the performance of her duties hereunder, according to the Company’s policies. 
 (c) Vacation. Employee will be entitled to twenty (20) vacation days per year, which will accrue in monthly increments.

 9. CONFIDENTIAL INFORMATION, RIGHTS AND DUTIES. 

 (a) Proprietary Information. Employee will, as a condition to commencing her employment with the Company, execute
and deliver to the Company an Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions in the form attached hereto as Exhibit A. 
 (b) Exclusive Property. Employee agrees that all Company-related business procured by the Employee, and all Company-related
business opportunities and plans made known to Employee while employed by the Company, are and shall remain the permanent and exclusive property of the Company. 
 (c) Non-Solicitation; Non-Competition. Employee agrees that following her last day of employment with the Company, she shall
continue to comply with the non-competition and non-solicitation obligations set forth in the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions for the entire time period set forth therein. 
 10. TERMINATION. The Parties each acknowledge that either of the Parties has the right to terminate Employee’s
employment with the Company at any time for any reason whatsoever, with or without Cause or advance notice. 

 (a) Payments through Termination. Except as provided herein, upon termination of
Employee’s employment for any reason, whether voluntary or involuntary, or due to death or Disability, the Company’s obligation to make payments shall terminate except the Company shall pay Employee (or her estate) any amount of Base
Salary and Bonus earned through the date of termination, any benefits vested through the date of termination, all unused vacation accrued through the date of termination, and any business expenses that were incurred but not reimbursed as of the date
of termination. Except as provided herein, vesting of the Options and any other equity incentives granted to Employee after the date hereof shall cease on the date of termination. 
 (b) Severance Benefits Prior to a Change of Control. In the event that Employee’s employment is terminated either without
Cause or due to her death or Disability prior to a Change of Control, Employee shall be entitled to receive the following severance pay and benefits in addition to the payments described in Section 10(a): 
 (i) Severance Pay. The equivalent of six (6) months (the “Severance Pay Period”) of Employee’s
Base Salary as in effect immediately prior to the date of her termination, payable on the same basis and at the same time as previously paid and subject to employment tax withholdings and deductions, commencing on the first regularly scheduled pay
date following the Effective Date of the Release; 
 (ii) Pro Rated Bonus. Unless the Employee’s termination is
due to her death, the Employee shall be deemed to have earned (on a pro rated basis) as of the date of her termination that portion of any Bonus that the Board of Directors, in its discretion, otherwise would have awarded the Employee as of such
date, based on her achieving (on a pro rated basis) the performance targets upon which Employee’s Bonus is based. The payment of any such pro rated Bonus shall be made by the Company in accordance with its standard policies and procedures
following the end of the year in which the Bonus was earned; and 
 (iii) Medical and Dental Benefits. Provided
that Employee or her dependents are eligible for and timely elect continued coverage under the Company’s group health and/or dental insurance plans pursuant to the federal law known as “COBRA,” for the duration of the Severance Pay
Period the Company shall reimburse Employee or her dependents for the cost of the COBRA premiums (less an amount equal to the employee portion of such premiums in accordance with the Company’s then standard employee policies regarding health
and dental insurance premiums), provided, however, that the Company’s obligation to pay the COBRA premiums in respect of health and/or dental insurance, as the case may be, will cease immediately in the event
Employee or her dependents (as the case may be) become eligible for other group health or dental insurance that is reasonably comparable in terms of the scope and cost of coverage during the Severance Pay Period, and Employee or her dependents shall
promptly notify the Company if he/they become eligible to be covered by other group health or dental insurance during the Severance Pay Period. Except for any right Employee has to continue participation in the Company’s group health and dental
plans under COBRA, all employee benefits shall terminate in accordance with the terms of the applicable benefit plans as of the date of termination of the Employee’s employment by the Company (or one of its subsidiaries). 
 (iv) Definition of Severance Benefits. The severance pay, pro rated Bonus and COBRA reimbursement described in Sections 10(b)(i)
through (iii) above are collectively referred to as the “Severance Benefits.” 

 (c) Severance Benefits Following a Change of Control. In the event that,
within twenty four (24) months following a Change of Control, Employee’s employment is terminated without Cause or as a result of death or Disability, or Employee resigns for Good Reason, then, in addition to the payments described in
Section 10(a), Employee shall be entitled to receive the Severance Benefits; provided, that the Severance Pay Period shall be twelve (12) months instead of six (6) months. 
 (d) Conditions for Receipt of Severance Benefits. The Company’s obligation to pay Severance Benefits shall be contingent upon
the Executive signing a release in the form attached as Exhibit B (“Release”) and a written acknowledgment of Employee’s continuing obligations under the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure
and Ownership of Inventions. 
 (e) Definition of Cause. For purposes of this Agreement,
“Cause” means (i) Employee’s incompetence or failure or refusal to perform satisfactorily any duties reasonably required of Employee by the Board of Directors and/or the Company (other than by reason of Disability),
including Employee’s continuing inattention to or neglect of her duties and responsibilities reasonably assigned to her by the Company and/or its Board of Directors, which failure or inaction is not cured by Employee within 30 days of receiving
written notice of such event or events giving rise to a claim of Cause; (ii) Employee’s violation of any law, rule or regulation (other than traffic violations, misdemeanors or similar offenses) or cease-and-desist order, court order,
judgment, regulatory directive or agreement or Employee’s conviction of or plea of nolo contendere to any felony or a crime involving moral turpitude; (iii) the commission or omission of or engaging in any act or practice that
constitutes a material breach of Employee’s fiduciary duty to the Company, involves personal dishonesty, fraud or misrepresentation on the part of Employee or demonstrates a willful or continuing disregard for the best interests of the Company;
(iv) Employee’s engaging in dishonorable or disruptive behavior, practices or acts that would be reasonably expected to harm or bring disrepute to the Company, its subsidiaries, its business or any of its customers, employees or vendors;
or (v) a breach by Employee of her obligations under the Agreement Re: Non-Competition, Non-Solicitation, Non-Disclosure and Ownership of Inventions or any Company code of conduct or ethics or other Company policies or practices. In any case
where the Company believes that the Employee may be terminated for Cause, it shall provide Employee with a written notice setting forth, in reasonable detail, the factual basis for such claimed Cause prior to or at the time of such termination.

 (f) Definition of Good Reason. For purposes of this Agreement, “Good Reason” means (i) the
failure of the Company to employ Employee in her current or a substantially similar position with the same reporting relationship, without regard to title, such that her duties and responsibilities are materially diminished without her written
consent (provided that she notifies the Company in writing of such diminution of duties within 45 days of the diminution); (ii) a reduction in Employee’s Base Salary and/or target annual Bonus without her written consent (unless
such reduction is in connection with a proportional reduction in compensation to all or substantially all of the Company’s employees); or (iii) a permanent relocation of Employee’s Primary Location more than 50 miles from her current
site of employment without Employee’s written consent. 

 (g) Definition of Disability. For purposes of this Agreement,
“Disability” means the Employee’s inability to carry out her job responsibilities for a continuous period of more than six (6) months as a result of illness (mental or physical), accident, or injury, as reasonably
determined in the sole discretion of the Board of Directors. 
 11. CHANGE IN CONTROL
BENEFITS. 
 (a) Definition of Change of Control. A “Change of Control” shall mean
any of the following events: (i) the dissolution or liquidation of the Company, (ii) any merger or consolidation of the Company with one (1) or more corporations where the Company is the surviving corporation and the stockholders of
the Company (including any holder of exchangeable shares of the Canadian subsidiaries) immediately prior to such transaction do not own at least fifty percent (50%) of the Company’s outstanding capital stock (assuming the exchange of all
outstanding exchangeable shares of the Canadian subsidiaries) immediately after such transaction, (iii) any merger or consolidation of the Company with one or more corporations where the Company is not the surviving corporation, (iv) a
sale of substantially all of the assets of the Company or fifty percent (50%) or more of the then outstanding shares of capital stock of the Company (assuming the exchange of all exchangeable shares of the Canadian subsidiaries) to another
corporation or entity, or (v) the entry by the Company into a joint venture, strategic partnership or other commercial agreement the result of which is that the Company is no longer responsible for marketing and sales of oritavancin in the
United States. 
 (b) Acceleration of Options upon a Change in Control. In the event that (i) Employee’s
employment is terminated without Cause at any time following a Change in Control or within thirty (30) days prior to the consummation of a Change of Control or (ii) Employee resigns for Good Reason at any time following a Change of
Control, then all Options issued to Employee in connection with this Agreement and any other options or shares of restricted stock then held by Employee that have not yet vested shall immediately vest such that all of the remaining unvested shares
under the Options and any other equity incentive granted to Employee during the course of her employment by the Company shall, at the time of the termination without Cause or resignation for Good Reason, immediately become vested shares. All other
terms and conditions set forth in the Options, the Plan, and applicable notices of stock option grant, stock option agreements and restricted stock agreements, if applicable, shall remain in full force and effect. 
 (c) Section 4999 Compliance. If the Company reasonably determines after consultation with its counsel that any benefit
accorded to the Employee under this Section 11 or any other provision or agreement between the Company and the Employee (“Other Agreement”) would cause the imposition of an excise tax upon the Employee under Section 4999
of the Internal Revenue Code of 1986, as amended (the “Code”), 

 
then the Company shall adjust the timing and/or the amount of any payment or benefit to the Employee pursuant to this Section 11 or Other Agreement so
that the excise tax imposed by Section 4999 shall not be imposed upon any such payment or benefit due to the Employee. The Company shall consult with the Employee regarding such adjustments, but shall retain the power to control the timing and
amounts of any such adjustments. 
 12. CODE SECTION 409A COMPLIANCE. Because of the
uncertainty of the application of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) to payments pursuant to this Agreement, including, without limitation, payments pursuant to Sections 10 and 11 hereof,
Employee agrees that if any such payments are subject to the provisions of Section 409A(a)(1) of the Code by reason of this Agreement, or any part thereof, being considered a “nonqualified deferred compensation plan” pursuant to
Section 409A of the Code, then such payments shall be made in accordance with, and this Agreement automatically shall be amended in such a manner as to prevent any current or future payment to the Employee under this Agreement or the vesting of
any Company stock option or other equity incentive held issued to the Employee becoming subject to Section 409A(a)(1) of the Code, including, without limitation, any necessary delay of six (6) months applicable to payment of deferred
compensation to a “specified employee” (as defined in Section 409A(2)(B)(i) of the Code) upon separation from service. In the event that a six month delay is required, on the first regularly scheduled pay date following the conclusion
of the delay period the Employee shall receive a lump sum payment in an amount equal to six (6) months of Employee’s Base Salary and thereafter, any remaining Severance Benefits shall be paid on the same basis and at the same time as
previously paid and subject to employment tax withholdings and deductions. The Company and the Employee shall consult together in good faith to determine the manner in which this Agreement should be amended to avoid the application of
Section 409A(a)(1) as provided herein while avoiding or minimizing any financial disadvantage to the Employee as might arise from such amendment, but in case of disagreement the decision of the Board of Directors shall govern, and the Company
and the Employee shall be bound thereby. 
 13. MISCELLANEOUS. 
 (a) Taxes; Withholding. Employee agrees to be responsible for the payment of any taxes due on any and all compensation, stock
options, equity incentives and other benefits provided by the Company pursuant to this Agreement and hereby acknowledges that all payments made by the Company to Employee under this Agreement shall be reduced by any tax or other amounts required to
be withheld by the Company under applicable law. Employee agrees to indemnify the Company and hold the Company harmless from any and all claims or penalties asserted against the Company for any failure to pay taxes due on any compensation, stock
option, or benefit provided by the Company pursuant to this Agreement. Employee expressly acknowledges that the Company has not made, nor herein makes, any representation about the tax consequences of any consideration provided by the Company to
Employee pursuant to this Agreement. 

 (b) Modification/Waiver. This Agreement may not be amended, modified, superseded,
canceled, renewed or expanded, or any terms or covenants hereof waived, except by a writing executed by each of the parties hereto or, in the case of a waiver, by the party waiving compliance. Failure of any party at any time or times to require
performance of any provision hereof shall in no manner affect her or its right at a later time to enforce the same. No waiver by a party of a breach of any term or covenant contained in this Agreement, whether by conduct or otherwise, in any one or
more instances shall be deemed to be or construed as a further or continuing waiver of that or any other term or covenant in this Agreement. 
 (c) Successors and Assigns. This Agreement shall be binding upon and shall inure to the benefit of any successors or assignees of the business of the Company. This Agreement shall not be assignable by the
Employee. 
 (d) Notices. All notices given hereunder shall be given by certified mail, addressed, or delivered by
hand, to the other party at her or its address as set forth herein, or at any other address hereafter furnished by notice given in like manner. Employee promptly shall notify Company of any change in Employee’s address. Each notice shall be
dated the date of its mailing or delivery and shall be deemed given, delivered or completed on such date. 
 (e) Governing
Law; Personal Jurisdiction and Venue. This Agreement and all disputes relating to this Agreement shall be governed in all respects by the laws of the Commonwealth of Massachusetts without regard to its conflicts of laws principles, and all
disputes hereunder shall be adjudicated in the courts of the Commonwealth of Massachusetts, to whose personal jurisdiction the Parties hereby consent. 
 (f) Entire Agreement. This Agreement, together with the Exhibits A and B attached hereto, sets forth the entire agreement and understanding of the parties hereto with regard to the employment of
the Employee by the Company and supersedes any and all prior agreements, arrangements and understandings, written or oral, pertaining to the subject matter hereof. No representation, promise or inducement relating to the subject matter hereof has
been made to a party that is not embodied in these Agreements, and neither of the Parties shall be bound by or liable for any alleged representation, promise or inducement not so set forth. In consideration of the benefits provided to Employee
hereunder, Employee hereby agrees that, in the event of her termination from the Company, such benefits shall be in complete satisfaction of any and all obligations that the Company may have to Employee.
 (g) Severability. If any portion or provision of this Agreement shall to any extent be declared illegal or unenforceable by a
court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each
portion and provision hereof shall be valid and enforceable to the fullest extent permitted by law. 

 (h) Employer. Employee shall be employed initially by the Company. During
the term of this Agreement, Employee may be transferred to the employment of a subsidiary or subsidiaries of the Company, in which event the term “Company” as used herein in reference to the employer of Employee shall refer to said
subsidiary(ies). Any such transfer to the employment of a subsidiary, and/or any such transfer back to the employment of Company, shall not otherwise alter or affect the terms or conditions of this Agreement, which shall continue to govern
Employee’s employment relationship. 
 (i) Counterparts. This Agreement may be executed in two counterparts, each
of which shall be an original and all of which together shall constitute one and the same instrument. 
 (j)
Fees. Each party shall be responsible for its own fees and expenses incurred in connection with negotiating this Agreement, provided that the Company shall reimburse the Employee for up to $2,500 for her legal expenses incurred
herewith. 
 [Remainder of Page Intentionally Left Blank.] 

 IN WITNESS WHEREOF, the Parties have each duly
executed this Agreement as of the day and year first above written. 
  

			
	TARGANTA THERAPEUTICS CORPORATION
		
	By:	 	/s/ Mark Leuchtenberger
	Name:	 	Mark Leuchtenberger
	Title:	 	President and CEO

  

	
	
	/s/ Mona Haynes
	MONA HAYNESSecond Amendment to Lease, by and between the Registrant and American Twine

 Exhibit 10.11.2 
 Second Amendment to Lease 
 Second Amendment made this 12th day of March, 2008 by and between Targanta Therapeutics
Corporation (“Tenant”) and American Twine Limited Partnership (“Landlord”). 
 WITNESSETH THAT 
 WHEREAS the parties have heretofore entered into a lease dated October 20, 2006, as amended by a First Amendment to Lease dated May 4, 2007 (the
“Lease”). 
 WHEREAS the Tenant wishes to expand the Premises demised under the Lease to include suites 2220 and 2230, which contain 3,210 rentable
square feet located on the second floor of the Building (as shown on Exhibit A attached) ( the “Second Expansion Space”) and return suite 1200 on the first floor of the Building (the “Returned Space”). 
 NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows: 
  

	 	1.	The effective date of this Second Amendment shall be the later of (i) May 1, 2008, or (ii) two (2) business days after Tenant receives written notice from
Landlord of the date that Landlord’s Work as defined in Exhibit B has been substantially completed and delivery of possession of the Second Expansion Space. 

  

	 	2.	The Premises currently contains 6,151 square feet. Effective after the effective date, the information contained in Section 1.1 of the Lease immediately following the Heading
“Premises” is amended to add suite 2220 and suite 2230 totaling 3,210 rentable square feet and to remove suite 1200, 1,471 rentable square feet. The total area of the Premises shall be 7,890 square feet. 

  

	 	3.	Effective after the effective date, the information contained in Section 1.1 of the Lease immediately following the heading Tenant’s Prorate Share is amended to add the
Pro Rata share for the Second Expansion Space, which is 2.77% and to remove the Pro Rata share for the Returned Space, which is 1.27%. The total Pro Rata share will be 6.81% 

  

	 	4.	Effective after the effective date, the information contained in Section 1.1 of the Lease immediately following the heading Parking Spaces is amended to add two
(2) additional parking spaces for the Second Expansion Space at $175.00 per month and remove one (1) parking space for suite 1200. Total number of parking spaces shall be five (5). 

  

	 	5.	Effective after the effective date, the information contained in Section 1.1 of the Lease, immediately following the heading Annual Fixed Rent shall be amended to remove the
Annual Fixed Rent for the Expansion Space defined in the First Amendment to Lease and to add the rent for the Second Expansion Space : 

  

					
	 5/1/08 – 5/31/08
	  	$135,269.40	  	($42.14/rsf/year)
	 6/1/08 – 4/30/09
	  	$136,746.00	  	($42.60/rsf/year)
	 5/1//09 – 10/31/09
	  	$138,479.40	  	($43.14/rsf/year)

	 	6.	Effective after the effective date, the Security Deposit under the Lease shall be amended to add $22,788 and remove $7,232 for a total of $55,548.00. 

  

	 	7.	Tenant retains its option to extend the term of the Lease as amended for two (2) periods of one (1) year each as defined in the Lease, such extension option to be
applicable to the entire Premises, and Landlord and Tenant confirm that the Tenant’s notice of extension must be given no later than April 30, 2009. 

  

	 	8.	On or before the effective date, Tenant will return suite 1200 subject to Section 5.1.9 Yield Up, of the Lease. Tenant shall not be required to remove any installations,
alterations or improvements from suite 1200. Tenant shall remove its trade fixtures, machinery, equipment and personal property therein. 

  

	 	9.	Tenant represents and warrants the Tenant has had no contact with any broker in connection with this Second Amendment. Landlord represents and warrants the Landlord has had no
contact with any broker in connection with this Second Amendment. Landlord and Tenant will each indemnify and hold the other harmless in the event that any other broker claims a commission from Landlord as a result of representing Tenant or from
Tenant as a result of representing Landlord. 

  

	 	10.	Landlord represents that, as of the date hereof, Tenant is not in default under the Lease, and that the Lease is in full force and effect. 

 Except as herein provided the terms and conditions of the Lease shall remain in full force and effect. Executed as a sealed instrument as of the day and year first above
written. 
  

									
	LANDLORD:	 		 	TENANT:
			
	American Twine Limited Partnership	 		 	Targanta Therapeutics Corporation
			
	ATLP, Inc., Its General Partner	 		 	
					
	By	 	/s/ Anthony Goschalk	 		 	By:	 	/s/ George Eldridge
	Name: Anthony Goschalk	 		 	Name: George Eldridge
	Title: President	 		 	 Title: CFO
           Duly Authorized

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