Document:

Warrant issued to Silicon Valley Bank, dated March 28, 2008

 Exhibit 4.7 
 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AND PURSUANT TO
THE PROVISIONS OF ARTICLE 5 BELOW, MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE
SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS EXEMPT FROM REGISTRATION. 
 WARRANT TO PURCHASE STOCK 
 Company: BG Medicine, Inc., a Delaware corporation 
 Number of Shares: As set forth below 
 Class of
Stock: As set forth below 
 Warrant Price: As set forth below 
 Issue Date: March 28, 2008 
 Expiration Date: March 28, 2018 

			
	Credit Facility:	 	This Warrant is issued in connection with that certain First Loan
		 	Modification Agreement, of even date herewith, to that certain Loan and
		 	Security Agreement dated as of November 9, 2007, between Silicon
		 	Valley Bank and the Company.

 THIS WARRANT CERTIFIES THAT, for good and valuable consideration, SILICON VALLEY BANK
(Silicon Valley Bank, together with any successor or permitted assignee or transferee of this Warrant or of any shares issued upon exercise hereof, is referred to hereinafter as “Holder”) is entitled to purchase the number of fully paid
and nonassessable shares (the “Shares”) of the class of securities (the “Class”) of the above-named company (the “Company”) at the Warrant Price, all as set forth herein and as adjusted pursuant to Article 2 of
this Warrant, subject to the provisions and upon the terms and conditions set forth in this Warrant. 
 A. Number and Class
of Shares; Warrant Price. 
 (1) Certain Definitions. As used herein, the following definitions have
the respective meanings set forth below: 
 “Acquisition” has the meaning given in Section 1.6.1
below. 
 “Common Stock” means the Company’s common stock, $0.001 par value per share, and any
securities of the Company into or for which the outstanding shares of such common stock may be converted, reclassified, reorganized or exchanged. 
 “IPO” means the Company’s initial, underwritten offering and sale of its shares to the public pursuant to an effective registration statement under the Securities Act of 1933, as amended.

 “Qualified Financing” means the first sale or issuance by the
Company after the Issue Date of this Warrant set forth above, in a single transaction or series of related transactions, of shares of its convertible preferred stock or other senior equity securities to one or more investors for cash for financing
purposes. 
 “Qualified Financing Securities” means the class and series of convertible preferred stock
or other senior equity security sold or issued by the Company in the Qualified Financing. 
 “Qualified
Financing Price” means the lowest price per share for which Qualified Financing Securities are sold or issued by the Company in the Qualified Financing. 
 “Series C Price” means $3.65, subject to adjustment from time to time upon the occurrence of events described in
Article 2 hereof. 
 “Series C Stock” shall mean the Company’s Series C Preferred Stock, $0.001
par value per share, and any securities of the Company into or for which the outstanding shares of Series C Preferred Stock may be converted, reclassified, reorganized or exchanged. 
 (2) Class of Shares. The class and series of the Company’s capital stock for which this Warrant shall be
exercisable (the “Class”) shall be Qualified Financing Securities; provided, that if upon consummation of the Qualified Financing, the Qualified Financing Price shall be greater than the then-effective Series C Price, then the
“Class” shall be Series C Stock from and after the consummation of such Qualified Financing; provided, further, that if, prior to the consummation of the Qualified Financing, there shall be an Acquisition or IPO, then
“Class” shall be Series C Stock as of immediately prior to (i) the effectiveness of the registration statement filed in connection with the IPO, or (ii) the closing of the Acquisition, as the case may be. 
 (3) Warrant Price. The purchase price per Share hereunder (the “Warrant Price”) shall be the Qualified
Financing Price; provided, that if upon consummation of the Qualified Financing, the Qualified Financing Price shall be greater than the then-effective Series C Price, then the “Warrant Price” shall be the Series C Price from and
after the consummation of such Qualified Financing; provided, further, that if, prior to the consummation of the Qualified Financing, there shall be an Acquisition or IPO, then the “Warrant Price” shall be the Series C Price
as of immediately prior to (i) the effectiveness of the registration statement filed in connection with the IPO, or (ii) the closing of the Acquisition, as the case may be; and in any event subject to further adjustment thereafter from
time to time in accordance with the provisions of this Warrant. 
 (4) Number of Shares. This Warrant
shall be exercisable for the Initial Shares plus the Additional Shares (if any). 
 (a) Initial Shares. As
used herein, “Initial Shares” means such number of shares of the Class as shall equal (i) $150,000, divided by (ii) the applicable Warrant Price (determined in accordance with paragraph A(3) above), subject to adjustment from
time to time in accordance with the provisions of this Warrant. 
  

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 (b) Additional Shares. This Warrant shall become exercisable for the
Additional Shares, if at all, on and as of the close of business on June 30, 2008 if the Company on or before such date shall not have consummated a Qualified Financing resulting in gross cash proceeds to the Company (net of finder, broker,
investment banker and similar fees and commissions) of at least $15,000,000. As used herein, “Additional Shares” means such number of additional shares of the Class as shall equal (i) $150,000, divided by (ii) the applicable
Warrant Price (determined in accordance with paragraph A(3) above), subject to adjustment from time to time in accordance with the provisions of this Warrant. 
 (c) As used herein, “Shares” means the Initial Shares, plus the Additional Shares (if any), as adjusted from time
to time in accordance with the provisions of this Warrant. 
 ARTICLE 1. EXERCISE. 
 1.1 Method of Exercise. Holder may exercise this Warrant by delivering the original of this Warrant together with a duly executed
Notice of Exercise in substantially the form attached as Appendix 1 to the principal office of the Company. Unless Holder is exercising the conversion right set forth in Article 1.2, Holder shall also deliver to the Company a check, wire transfer
(to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price for the Shares being purchased. 
 1.2 Conversion Right. In lieu of exercising this Warrant as specified in Article 1.1, Holder may from time to time convert this Warrant, in whole or in part, into a number of Shares determined by
dividing (a) the aggregate fair market value of the Shares or other securities otherwise issuable upon exercise of this Warrant minus the aggregate Warrant Price of such Shares by (b) the fair market value of one Share. The fair market
value of the Shares shall be determined pursuant to Article 1.3. 
 1.3 Fair Market Value. If the Company’s Common
Stock is traded in a public market and the Shares are Common Stock, the fair market value of a Share shall be the closing price of a share of Common Stock reported for the business day immediately before Holder delivers this Warrant together with
its Notice of Exercise to the Company (or in the instance where the Warrant is exercised immediately prior to the effectiveness of the IPO, the “price to public” per share price specified in the final prospectus relating to such offering).
If the Company’s Common Stock is traded in a public market and the Shares are preferred stock, the fair market value of a Share shall be the closing price of a share of the Company’s Common Stock reported for the business day immediately
before Holder delivers this Warrant together with its Notice of Exercise to the Company (or, in the instance where the Warrant is exercised immediately prior to the effectiveness of the IPO, the initial “price to public” per share price
specified in the final prospectus relating to such offering), in both cases, multiplied by the number of shares of the Company’s Common Stock into which a Share is convertible. If the Company’s Common Stock is not traded in a public
market, the Board of Directors of the Company shall determine fair market value in its reasonable good faith judgment. 
  

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 1.4 Delivery of Certificate and New Warrant. Promptly after Holder exercises or
converts this Warrant and, if applicable, the Company receives payment of the aggregate Warrant Price, the Company shall deliver to Holder certificates for the Shares acquired and, if this Warrant has not been fully exercised or converted and has
not expired, a new Warrant representing the Shares not so acquired. 
 1.5 Replacement of Warrants. On receipt of
evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and amount to the
Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor. 
 1.6 Treatment of Warrant Upon Acquisition of Company. 
 1.6.1 “Acquisition”. For the purpose of this Warrant, “Acquisition” means any sale, license, or
other disposition of all or substantially all of the assets of the Company, or any reorganization, consolidation, merger or sale of outstanding capital stock of the Company where the holders of the Company’s securities before the transaction
beneficially own less than a majority of the outstanding voting securities of the surviving entity after the transaction (but excluding the IPO). 
 1.6.2 Treatment of Warrant at Acquisition. 
 A) Upon the
written request of the Company, Holder agrees that, in the event of an Acquisition in which the sole consideration is cash, either (a) Holder shall exercise its conversion or purchase right under this Warrant and such exercise will be deemed
effective immediately prior to the consummation of such Acquisition or (b) if Holder elects not to exercise the Warrant, this Warrant will expire upon the consummation of such Acquisition. The Company shall provide the Holder with written
notice of its request relating to the foregoing (together with such reasonable information as the Holder may request in connection with such contemplated Acquisition giving rise to such notice), which is to be delivered to Holder not less than ten
(10) days prior to the closing of the proposed Acquisition. 
 B) Upon the written request of the Company,
Holder agrees that, in the event of an Acquisition that is an “arms length” sale of all or substantially all of the Company’s assets (and only its assets) to a third party that is not an Affiliate (as defined below) of the Company (a
“True Asset Sale”), either (a) Holder shall exercise its conversion or purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such Acquisition or (b) if Holder elects
not to exercise the Warrant, this Warrant will continue until the Expiration Date if the Company continues as a going concern following the closing of any such True Asset Sale. The Company shall provide the Holder with written notice of its request
relating to the foregoing (together with such reasonable information as the Holder may request in connection with such contemplated Acquisition giving rise to such notice), which is to be delivered to Holder not less than ten (10) days prior to
the closing of the proposed Acquisition. 
  

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 C) Upon the closing of any Acquisition other than those particularly
described in subsections (A) and (B) above, the successor entity shall assume the obligations of this Warrant, and this Warrant shall be exercisable for the same securities, cash, and property as would be payable for the Shares issuable
upon exercise of the unexercised portion of this Warrant as if such Shares were outstanding on the record date for the Acquisition and subsequent closing. The Warrant Price and/or number of Shares shall be adjusted accordingly. 
 As used herein “Affiliate” shall mean any person or entity that owns or controls directly or indirectly ten percent (10%) or more of
the stock of Company, any person or entity that controls or is controlled by or is under common control with such persons or entities, and each of such person’s or entity’s officers, directors, joint venturers or partners, as applicable.

 ARTICLE 2. ADJUSTMENTS TO THE SHARES. 
 2.1 Stock Dividends, Splits, Etc. If the Company declares or pays a dividend on the outstanding shares of the Class payable in Common Stock or other securities after the date hereof, then upon
exercise of this Warrant, for each Share acquired, Holder shall receive, without cost to Holder, the total number and kind of securities to which Holder would have been entitled had Holder owned the Shares of record as of the date the dividend
occurred. If the Company subdivides the outstanding shares of the Class after the date hereof by reclassification or otherwise into a greater number of shares or takes any other action after the date hereof which increases the amount of Common Stock
into which the one share of the Class is convertible, the number of Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the outstanding shares of the Class are combined or
consolidated, by reclassification or otherwise, after the date hereof into a lesser number of shares, the Warrant Price shall be proportionately increased and the number of Shares shall be proportionately decreased. 
 2.2 Reclassification, Exchange, Combinations or Substitution. Upon any reclassification, exchange, substitution, or other event that
results in a change of the number and/or class of the securities issuable upon exercise or conversion of this Warrant, Holder shall be entitled to receive, upon exercise or conversion of this Warrant, the number and kind of securities and property
that Holder would have received for the Shares if this Warrant had been exercised immediately before such reclassification, exchange, substitution, or other event. Such an event shall include, without limitation, any automatic conversion of the
outstanding or issuable securities of the Company of the same class or series as the Shares to Common Stock pursuant to the terms of the Company’s Amended and Restated Certificate of Incorporation, as amended and/or restated and in effect from
time to time (the “Certificate”). The Company or its successor shall promptly issue to Holder an amendment to this Warrant setting forth the number and kind of such new securities or other property issuable upon exercise or conversion of
this Warrant as a result of such reclassification, exchange, substitution or other event that results in a change of the number and/or class of securities issuable upon exercise or conversion of this Warrant. The amendment to this Warrant shall
provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments provided for in this Article 2 including, without limitation, adjustments to the Warrant Price and to the number of securities or property issuable
upon exercise of the new Warrant. The provisions of this Article 2.2 shall similarly apply to successive reclassifications, exchanges, substitutions, or other events. 
  

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 2.3 Adjustments for Diluting Issuances. The number of shares of Common Stock issuable
upon conversion of the Shares shall be subject to adjustment, from time to time in the manner set forth in the Certificate as if the Shares were issued and outstanding on and as of the date of any such required adjustment. The anti-dilution
provisions set forth for the Class in the Certificate in effect as of the Issue Date may not be amended, modified or waived, without the prior written consent of Holder unless such amendment, modification or waiver affects the rights associated with
the Shares in the same manner as such amendment, modification or waiver affects the rights associated with all other shares of the Class. 
 2.4 No Impairment. The Company shall not, by amendment of the Certificate or through a reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any
other voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed under this Warrant by the Company, but shall at all times in good faith assist in carrying out of all the provisions of this
Article 2 and in taking all such action as may be necessary or appropriate to protect Holder’s rights under this Article against impairment. 
 2.5 Fractional Shares. No fractional Shares shall be issuable upon exercise or conversion of the Warrant and the number of Shares to be issued shall be rounded down to the nearest whole Share. If a
fractional share interest arises upon any exercise or conversion of the Warrant, the Company shall eliminate such fractional share interest by paying Holder the amount computed by multiplying the fractional interest by the fair market value of a
full Share. 
 2.6 Certificate as to Adjustments. Upon each adjustment of the Warrant Price, Class and/or number of
Shares, the Company shall promptly notify Holder in writing, and, at the Company’s expense, promptly compute such adjustment, and furnish Holder with a certificate of its Chief Financial Officer setting forth such adjustment and the facts upon
which such adjustment is based. The Company shall, upon written request, furnish Holder a certificate setting forth the Warrant Price, Class and number of Shares in effect upon the date thereof and the series of adjustments leading to such Warrant
Price, Class and number of Shares. 
 ARTICLE 3. REPRESENTATIONS AND COVENANTS OF THE COMPANY. 
 3.1 Representations and Warranties. The Company represents and warrants to, and agrees with, the Holder as follows: 
 (a) The Series C Price is not greater than the price per share at which shares of Series C Stock were last issued in an
arms-length transaction in which at least $500,000 of such shares were sold. 
 (b) All Shares which may be
issued upon the exercise of the purchase right represented by this Warrant, and all securities, if any, issuable upon conversion of the Shares, shall, upon issuance, be duly authorized, validly issued, fully paid and nonassessable, and free of any
liens and encumbrances except for restrictions on transfer provided for herein or under applicable federal and state securities laws. 
 (c) The Company’s capitalization table attached hereto as Schedule 1 is true and complete as of the Issue Date. 
  

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 3.2 Notice of Certain Events. If the Company proposes at any time (a) to declare
any dividend or distribution upon the outstanding shares of the Class, whether in cash, property, stock, or other securities and whether or not a regular cash dividend; (b) to offer for subscription or sale pro rata to the holders of the
outstanding shares of the Class any additional shares of any class or series of the Company’s stock; (c) to effect any reclassification, reorganization or recapitalization of any of its stock; (d) to effect an Acquisition or to
liquidate, dissolve or wind up; or (e) offer holders of registration rights the opportunity to participate in an underwritten public offering of the Company’s securities for cash, then, in connection with each such event, the Company shall
give Holder: (1) at least 10 days prior written notice of the date on which a record will be taken for such dividend, distribution, or subscription rights (and specifying the date on which the holders of shares of the same class and series as
the Shares will be entitled thereto) or for determining rights to vote, if any, in respect of the matters referred to in (c) and (d) above; (2) in the case of the matters referred to in (c) and (d) above at least 10 days
prior written notice of the date when the same will take place (and specifying the date on which the holders of shares of the same class and series as the Shares will be entitled to exchange their shares for the securities or other property
deliverable upon the occurrence of such event); and (3) in the case of the matter referred to in (e) above, the same notice as is given to the holders of such registration rights. 
 3.3 Registration Under Securities Act of 1933, as amended. The Company agrees that the Shares or, if the Shares are convertible into
Common Stock of the Company, such Common Stock, shall have certain incidental, or “Piggyback,” registration rights pursuant to and as set forth in Sections 3 through 11, 13 and 15(b), 15(d) and 15(h) (the “Applicable Sections”)
of that certain Third Amended and Restated Investor Rights Agreement dated as of May 1, 2007 among the Company and the other parties named therein, as amended and/or restated and in effect from time to time (the “Rights Agreement”)
pursuant to the terms, conditions and restrictions of the Applicable Sections. The Applicable Sections in effect as of the Issue Date may not be amended, modified or waived without the prior written consent of Holder unless such amendment,
modification or waiver affects the rights associated with the Shares in the same manner as such amendment, modification, or waiver affects the rights associated with all other shares of the Class held by holders who are parties to the Rights
Agreement. 
 3.4 No Shareholder Rights. Except as provided in this Warrant, Holder will not have any rights as a
shareholder of the Company until the exercise of this Warrant. 
 3.5 Certain Information. The Company agrees to provide
Holder at any time and from time to time with such information as Holder may reasonably request for purposes of Holder’s compliance with regulatory, accounting and reporting requirements applicable to Holder. 
 ARTICLE 4. REPRESENTATIONS, WARRANTIES OF THE HOLDER. The Holder represents and warrants to the Company as follows: 
 4.1 Purchase for Own Account. This Warrant and the securities to be acquired upon exercise of this Warrant by Holder will be acquired
for investment for Holder’s account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act. Holder also represents that it has not been formed for the specific purpose of acquiring
this Warrant or the Shares. 
  

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 4.2 Disclosure of Information. Holder has received or has had full access to all the
information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. Holder further has had an opportunity to ask questions and receive answers from
the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the Company possessed such information or could acquire it without unreasonable effort
or expense) necessary to verify any information furnished to Holder or to which Holder has access. 
 4.3 Investment
Experience. Holder understands that the purchase of this Warrant and its underlying securities involves substantial risk. Holder has experience as an investor in securities of companies in the development stage and acknowledges that Holder can
bear the economic risk of such Holder’s investment in this Warrant and its underlying securities and has such knowledge and experience in financial or business matters that Holder is capable of evaluating the merits and risks of its investment
in this Warrant and its underlying securities and/or has a preexisting personal or business relationship with the Company and certain of its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the
character, business acumen and financial circumstances of such persons. 
 4.4 Accredited Investor Status. Holder is an
“accredited investor” within the meaning of Regulation D promulgated under the Act. 
 4.5 The Act. Holder
understands that this Warrant and the Shares issuable upon exercise or conversion hereof have not been registered under the Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature
of the Holder’s investment intent as expressed herein. Holder understands that this Warrant and the Shares issued upon any exercise or conversion hereof must be held indefinitely unless subsequently registered under the Act and qualified under
applicable state securities laws, or unless exemption from such registration and qualification are otherwise available. 
 ARTICLE 5.
MISCELLANEOUS. 
 5.1 Term: This Warrant is exercisable in whole or in part at any time and from time to time on
or before the Expiration Date. 
 5.2 Legends. This Warrant and the Shares (and the securities issuable, directly or
indirectly, upon conversion of the Shares, if any) shall be imprinted with a legend in substantially the following form: 
 THIS
WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE ACT, OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AND PURSUANT TO THE PROVISIONS OF ARTICLE 5 OF THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE COMPANY TO SILICON
VALLEY BANK DATED AS OF MARCH 28, 2008, MAY NOT BE OFFERED, SOLD OR OTHERWISE

  

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TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE
ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS EXEMPT FROM REGISTRATION. 
 5.3
Compliance with Securities Laws on Transfer. This Warrant and the Shares issuable upon exercise of this Warrant (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) may not be transferred or assigned in
whole or in part without compliance with applicable federal and state securities laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory
to the Company, as reasonably requested by the Company). The Company shall not require Holder to provide an opinion of counsel if the transfer is to SVB Financial Group (Silicon Valley Bank’s parent company) or any other affiliate of Holder,
provided that any such transferee is an “accredited investor” as defined in Regulation D promulgated under the Act. 
 5.4 Transfer Procedure. After receipt by Silicon Valley Bank (“Bank”) of the executed Warrant, Bank will transfer all of this Warrant to SVB Financial Group, Holder’s parent company. Subject to the provisions of
Article 5.3 and upon providing the Company with written notice, SVB Financial Group and any subsequent Holder may transfer all or part of this Warrant or the Shares issuable upon exercise of this Warrant (or the securities issuable directly or
indirectly, upon conversion of the Shares, if any) to any transferee, provided, however, in connection with any such transfer, SVB Financial Group or any subsequent Holder will give the Company notice of the portion of the Warrant being transferred
with the name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to the transferee(s) (and Holder if applicable). The Company may refuse to transfer this Warrant or the
Shares to any person who directly competes with the Company, unless, in either case, the stock of the Company is publicly traded. 
 5.5 Notices. All notices and other communications from the Company to the Holder, or vice versa, shall be deemed delivered and effective when given personally or mailed by first-class registered or certified mail, postage prepaid, at
such address as may have been furnished to the Company or Holder, as the case may (or on the first business day after transmission by facsimile) be, in writing by the Company or such holder from time to time. All notices to Holder shall be addressed
as follows until the Company receives notice of a change of address in connection with a transfer or otherwise: 
 SVB Financial
Group 
 Attn: Treasury Department 
 3003 Tasman Drive, HA 200 
 Santa Clara, CA 95054 
 Telephone: 408-654-7400 
 Facsimile: 408-496-2405 
  

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 Notice to the Company shall be addressed as follows until Holder receives notice of a change
in address: 
 BG Medicine, Inc. 
 Attn: Mark Shooman 
 610 Lincoln Street North 
 Waltham, MA 02451 
 Telephone: 781-890-1199 
 Facsimile: 781-895-1119 
 5.6 Waiver. This Warrant and any term hereof may be changed, waived, discharged or terminated only by an instrument in writing signed
by the party against which enforcement of such change, waiver, discharge or termination is sought. 
 5.7 Attorney’s
Fees. In the event of any dispute between the parties concerning the terms and provisions of this Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including
reasonable attorneys’ fees. 
 5.8 Automatic Conversion upon Expiration. In the event that, upon the Expiration
Date, the fair market value of one Share (or other security issuable upon the exercise hereof) as determined in accordance with Article 1.3 above is greater than the Warrant Price in effect on such date, then this Warrant shall automatically be
deemed on and as of such date to be converted pursuant to Article 1.2 above as to all Shares (or such other securities) for which it shall not previously have been exercised or converted, and the Company shall promptly deliver a certificate
representing the Shares (or such other securities) issued upon such conversion to Holder. 
 5.9 Counterparts. This
Warrant may be executed in counterparts, all of which together shall constitute one and the same agreement. 
 [Remainder of
page left blank intentionally] 
  

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 5.10 Governing Law. This Warrant shall be governed by and construed in accordance
with the laws of the Commonwealth of Massachusetts, without giving effect to its principles regarding conflicts of law. 
  

			
	“COMPANY”
	
	BG MEDICINE, INC.
		
	By:	 	/ S/ Pieter Muntendam
	Name:	 	Pieter Muntendam
		 	(Print)
	Title:	 	President
	
	“HOLDER”
	
	SILICON VALLEY BANK
		
	By:	 	/S/ Clark Hayes
	Name:	 	Clark Hayes
		 	(Print)
	Title:	 	R. M.

  

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 APPENDIX 1 
 NOTICE OF EXERCISE 
 1. Holder elects to purchase
                     shares of the Common/Series              Preferred
[strike one] Stock of                              pursuant to the terms of the attached Warrant, and
tenders payment of the purchase price of the shares in full. 
 [or] 
 1. Holder elects to convert the attached Warrant into Shares/cash [strike one] in the manner specified in the Warrant. This conversion is
exercised for                                      of the
Shares covered by the Warrant. 
 [Strike paragraph that does not apply.] 
 2. Please issue a certificate or certificates representing the Shares in the name specified below: 

	
	
	  
	Holders Name
	
	 
	
	  
	(Address)

 3. By its execution below and for the benefit of the Company, Holder hereby restates
each of the representations and warranties in Article 4 of the Warrant as of the date hereof. 
  

			
	HOLDER:
	
	 

			
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 
		
	(Date):	 	 

  

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 SCHEDULE 1 
 Company Capitalization Table 
 See attached 
  

 13Second Amendment to Lease

 Exhibit 10.1 
 HOBBS BROOK OFFICE PARK 
 610 Lincoln Street, Waltham,
Massachusetts 
 SECOND AMENDMENT TO LEASE, SUBLEASE, AND 
 ASSIGNMENT, ASSUMPTION AND AMENDMENT OF SUBLEASE AGREEMENT 
 BG Medicine, Inc. 
 Second Amendment to Lease, Sublease, and Assignment, Assumption and Amendment of Sublease
Agreement (“Second Amendment”) dated as of May 19, 2009, between 610 Lincoln LLC, a Delaware limited liability company (“Landlord”), and BG Medicine, Inc., a Delaware corporation (“Tenant”).

 Background 
 A. Landlord, as landlord, and GPC Biotech Inc. (“GPC”), as tenant, entered into that certain Lease dated as of March 26, 2001, as amended by that certain First Amendment to Lease
dated as of January 1, 2002 (as amended, the “Prime Lease”), for certain premises located within the building at 610 Lincoln Street, Waltham, Massachusetts described in the Prime Lease. 
 B. GPC, as sublessor, and Tenant, as sublessee, entered into that certain Sublease dated April 14, 2005 (the
“Sublease”), with respect to certain portions of the premises under the Prime Lease (the “Premises”). 
 C. Landlord, Tenant and GPC entered into that certain Assignment, Assumption and Amendment of Sublease Agreement dated as of December 31, 2007 (the “Assignment”), under which
Landlord assumed from GPC the interest of sublandlord under the Sublease as more fully set forth in the Assignment. 
 D. The
Prime Lease, as it related to Landlord and GPC, terminated and Tenant continued to lease the Premises from Landlord under the terms of the Prime Lease, as affected by the Sublease and the Assignment (collectively, the “Original
Lease”). Capitalized terms used and not otherwise defined in this Second Amendment shall have the meanings ascribed to them in the Original Lease. 
 E. Landlord and Tenant desire that Tenant should continue to lease the Premises for an extended term and that certain modifications and amendments be made to the Original Lease, all as more fully set
forth in this Second Amendment. 
 Agreement 
 FOR VALUE RECEIVED, Landlord and Tenant agree as follows: 
 1. Lease. The First Amendment to Lease dated as of January 1, 2002, the Sublease and the Assignment are hereby deleted in their entirety. The following provisions of the Original Lease are
hereby deleted: Articles/Sections: 1.1 (except, however, the definitions of “Landlord’s

 
Address”, “Land”, “Building”, “Total Rentable Floor Area of Building”, “Permitted Uses” and “Public Liability Insurance” are incorporated
herein), 1.2, the first four (4) sentences of 2.1 (and the words “Until the Delivery Date for Premises B,” of the fifth sentence of 2.1), the words “, and the Special Permit dated March 9, 1992 allows Tenant to operate the
Premises for the Permitted Uses” in the last sentence of the second paragraph of 2.1, the third paragraph of 2.1, 2.4, the first paragraph of 2.5, 2.6.1, the last paragraph of 2.6.3, Article III, 4.1.4, 4.3.3, 4.4, 8.3, 8.6, 8.18(e), 8.20, the
last grammatical paragraph of 9.2; and Exhibits A, B, E, F, H, I and J. 
 From and after the date hereof, the Lease is comprised of the
Original Lease (as affected by the preceding sentences), as amended by this Second Amendment, and as it may be amended, modified and supplemented from time to time (the “Lease”). 
 2. Premises. For the rent and upon the terms and conditions in the Lease, Landlord hereby leases to Tenant and Tenant leases from
Landlord the Premises, consisting of (a) 15,050 rentable square feet of space located on the first and third floors of the Building (the “Office Space Premises”) and (b) 6,500 rentable square feet of laboratory space
located on the third floor of the Building (the “Lab Space Premises”), as shown on Exhibit 1 attached hereto. 
 3. As-Is. The Premises are being leased in their “as-is” condition without representation or warranty by Landlord, and Landlord shall not be required to perform any improvement work or make any alterations in connection
with Tenant’s occupancy of the Premises during the Term. 
 4. Term Extension. The Term of the Lease is hereby
extended for an additional approximately four (4) year term commencing on the date of this Second Amendment and expiring on March 31, 2013, which shall be the new Term Expiration Date. 
 5. Security Deposit. Tenant previously provided to Landlord a letter of credit issued by Silicon Valley Bank dated October 10,
2008, as amended, with an expiration date of June 30, 2009. On or before June 1, 2009, Tenant shall deliver to Landlord a replacement letter of credit complying with the requirements of the Lease, including, without limitation,
Section 8.18, except that the amount of such letter of credit shall be $36,667.00. 
 6. Annual Fixed Rent.
Commencing on April 1, 2009, Tenant covenants and agrees to pay Annual Fixed Rent to Landlord in equal monthly installments on the first day of each calendar month during the Term, as follows: 
 OFFICE SPACE PREMISES: 
  

										
	 Time Period
	  	Rent Per Rentable
Square Foot	  	Annual Fixed Rent	  	Monthly Rent
	 April 1, 2009 through initial Term Expiration Date
	  	$	28.00	  	$	421,400.00	  	$	35,116.67

  

 2 

 LAB SPACE PREMISES: 
  

										
	 Time Period
	  	Rent Per Rentable
Square Foot	  	Annual Fixed Rent	  	Monthly Rent
	 April 1, 2009 through initial Term Expiration Date
	  	$	30.00	  	$	195,000.00	  	$	16,250.00

 All payments shall be made without billing or demand and without deduction, setoff or
counterclaim. All payments shall be made to Landlord at Landlord’s Address as specified in Section 1.1, or to such other entities at such other places as Landlord may from time to time designate. 
 7. Additional Rent – Office Space Premises. Commencing on April 1, 2009, Tenant covenants and agrees to pay to Landlord, as
“Additional Rent”, at the times and in the manner set forth in Section 2.6 of the Lease, (i) an amount equal to the product of (a) the Rentable Floor Area of the Office Space Premises and (b) the excess
(if any) of Landlord’s Operating Expenses per square foot of Rentable Floor Area of the Building over Base Operating Expenses per Square Foot of Rentable Floor Area of the Building, (ii) an amount equal to the product of (a) the
Rentable Floor Area of the Office Space Premises and (b) the excess (if any) of Landlord’s Taxes per square foot of Rentable Floor Area of the Building over Base Taxes Per Square Foot of Rentable Floor Area of the Building, provided that
if less than the Total Rentable Floor Area of the Building is occupied at any time during such period, Landlord may extrapolate components of Landlord’s Operating Expenses and Landlord’s Taxes as though the Total Rentable Floor Area of the
Building had been ninety-five percent (95%) occupied at all times during such period, and (iii) any other charges payable by Tenant to Landlord under the Lease. “Rentable Floor Area of the Office Space Premises” is
conclusively agreed to mean 15,050 square feet located on the first and third floors of the Building. “Base Operating Expenses per Square Foot of Rentable Floor Area of the Building” means Landlord’s Operating Expenses per
square foot of Rentable Floor Area of the Building for the calendar year 2009, adjusted to reflect 95% occupancy. “Base Taxes Per Square Foot of Rentable Floor Area of the Building” means Landlord’s Taxes per square foot of
Rentable Floor Area of the Building for the calendar year 2009. “Total Rentable Floor Area of the Building” is conclusively agreed to be 85,430 square feet. The term “rent” as used in the Lease means Annual Fixed
Rent and Additional Rent as set forth in the Lease. Appropriate adjustments shall be made for any portion of a year at the beginning or end of the Term. 
 For the avoidance of doubt, the obligations of Tenant to pay a portion of Landlord’s Operating Expenses and Landlord’s Taxes set forth in this Section 7 and Section 8 below supersede
and replace any such obligations as specified under Section 2.6.1 of the Lease. 
 8. Additional Rent – Lab
Space Premises. It is intended by Landlord and Tenant that the Annual Fixed Rent for the Lab Space Premises be net of all costs and expenses related to the Lab Space Premises. On account of the Lab Space Premises only, Tenant shall during the
Term pay to Landlord, as Additional Rent hereunder, (a) the Tenant’s Percentage (as hereinafter

  

 3 

 
defined) of Common Expenses (as hereinafter defined), and (b) one hundred percent (100%) of Lab Space Premises Operating Costs (as hereinafter defined). The costs and expenses payable
by Tenant with respect to the Lab Space Premises are collectively referred to herein as the “Tenant’s Share”. For purposes of the Lease, the following terms shall have the following respective meanings: 
 (i) “Tenant’s Percentage” shall mean the rentable square footage of the Lab Space Premises divided by the rentable
square footage of the Building, expressed as a percentage. As of the date hereof, based upon the Lab Space Premises as of such date containing 6,500 rentable square feet and the Building as of such date containing 85,430 rentable square feet, the
Tenant’s Percentage shall be seven and sixty-one one-hundredths percent (7.61%). 
 (ii) “Common Expenses”
shall mean Landlord’s Operating Expenses and Landlord’s Taxes, both as defined in the Lease. 
 (iii) “Lab
Space Premises Operating Costs” shall mean, in each case solely to the extent not otherwise payable by Tenant under the definition of Common Expenses above, (x) all out-of-pocket, third party costs and expenses incurred by Landlord in
providing services directly to the Lab Space Premises including, without limitation, those services listed in Exhibit 5, and (y) Tenant’s pro rata share of any out-of-pocket, third party costs incurred by Landlord for any other
permits, licenses, services and other costs incurred by Landlord with respect to operation and maintenance of laboratory facilities in the Building including, without limitation, costs incurred in connection with the licenses and services detailed
in Exhibit 3. For purposes of this Section 8, “Tenant’s pro rata share” shall mean the Rentable Floor Area of the Lab Space Premises divided by the Rentable Floor Area of laboratory facilities in the Building
benefited by such permit, license or service, as determined by Landlord from time to time, expressed as a percentage. 
 Landlord may bill Tenant for Tenant’s Share based on reasonably estimated projected costs (the “Estimated Costs”), in which case Tenant shall pay Tenant’s Share, as Additional Rent hereunder, based on such
estimated amounts, such estimates to be based on the estimates by Landlord. At least annually, and not later than fifteen (15) days after Landlord’s annual accounting as more particularly described under Section 2.6.2 of the
Lease, Landlord shall provide to Tenant copies of all records and documents relating to the annual accounting including, but not limited to, all materials and reconciliations supplied by Landlord. Tenant shall have the right to dispute any such
charges in the manner set forth in Section 2.6.2 of the Lease. To the extent Tenant’s Share of the Estimated Costs exceeds Tenant’s Share of the actual costs and expenses, Landlord shall credit (or promptly refund, as
appropriate) such excess amount against amounts due from Tenant hereunder. To the extent Tenant’s Share of actual costs and expenses exceeds Tenant’s Share of Estimated Costs, Tenant shall pay Landlord the amount of such deficiency upon
demand as Additional Rent hereunder. 
 9. Electricity. From and after the Extension Commencement Date, the second
sentence of Section 2.7 is hereby deleted and replaced with the following: “Tenant covenants and agrees to pay, as Additional Rent, the cost of such electricity, which shall be separately metered or check metered and billed to
Tenant monthly without markup.” 
  

 4 

 10. Additional Tenant Rights. Subject to the terms and conditions of the Lease,
Landlord has agreed to make available to Tenant, in connection with Tenant’s use and occupancy of the Premises, certain services, and to authorize Tenant to use certain permits and licenses, held by Landlord, including those services and
licenses listed on Exhibit 3 attached hereto, jointly with Landlord and others who may be authorized by Landlord from time to time, as well as the following: 
 (a) Landlord shall provide customary janitorial and custodial services (i) to the Lab Space Premises in accordance with the schedule attached hereto as Exhibit 5, and (ii) to the Office
Space Premises in accordance with the schedule attached hereto as Exhibit 6. 
 (b) Landlord grants Tenant a license
to the use, occupancy and operation of the Premises under the auspices of all existing municipal, state and federal licenses and permits held by Landlord with respect to the use and operation of laboratory and research facilities within the Premises
including, without limitation, the Sewer Use Discharge Permit. Tenant represents, warrants and covenants that it has obtained and will maintain at its sole expense its own Flammable Storage Permit for the materials and up to the maximum quantities
set forth on Exhibit 4 attached hereto. Landlord will maintain the Sewer Use Discharge Permit unless the Massachusetts Water Resource Authority requires otherwise; in such event, Landlord shall provide written notice thereof to Tenant and
Tenant shall apply in its own name for, and obtain at its sole expense its own Sewer Use Discharge Permit. 
 (c) Landlord
grants Tenant the right to connect to Landlord’s emergency generator, to the extent Landlord’s generator has capacity to support Tenant’s usage as reasonably determined by Landlord, through the outlets existing in the Premises as of
the date hereof. 
 11. Early Termination Rights. During the Term, Tenant shall have the right to terminate this Lease
effective between September 1, 2010 and the date six (6) months before the Term Expiration Date (the “Tenant’s Early Termination Window”), provided that Tenant provides Landlord with written notice given at least six
(6) months (but not more than twelve (12) months) prior to the effective date of such termination (the “Tenant’s Early Termination Date”) and provided that Tenant’s Early Termination Date is within Tenant’s
Early Termination Window. If Tenant elects to terminate this Lease in accordance with this Section 11, and if Tenant’s Early Termination Date is on or prior to January 31, 2011, then Tenant shall pay to Landlord on or before
Tenant’s Early Termination Date an amount equal to two (2) months Annual Fixed Rent. In the event of such election by Tenant, this Lease shall terminate on Tenant’s Early Termination Date as if Tenant’s Early Termination Date
were the Term Expiration Date hereof. 
 During the Term, Landlord shall have a one time right to terminate this Lease effective
between March 31, 2011 and the date six (6) months before the Term Expiration Date (the “Landlord’s Early Termination Window”), provided that (i) Landlord provides Tenant with written notice
(“Landlord’s Termination Notice”) given at least six (6) months (but not more than twelve (12) months) prior to the effective date of such termination (the “Landlord’s Early Termination Date”),
(ii) Landlord’s Early Termination Date is within Landlord’s Early Termination Window, and (iii) Landlord elects to exercise this early termination right following its acceptance of a bona fide, non-binding, arms-length term sheet
from an unaffiliated third

  

 5 

 
party (the “Replacement Tenant”) to lease the full Building and provides to Tenant a copy of such term sheet (which Landlord may reasonably redact to protect information Landlord
deems to be confidential) along with Landlord’s Termination Notice. Landlord shall have no obligation to pay Tenant in connection with Landlord’s election to terminate the Lease under this Section 11. In the event of such election by
Landlord, this Lease shall terminate on Landlord’s Early Termination Date as if Landlord’s Early Termination Date were the Term Expiration Date hereof. Notwithstanding the foregoing, if Landlord and the Replacement Tenant have not executed
a lease within one hundred twenty (120) days after delivery of Landlord’s Termination Notice, Landlord may (but shall not be obligated to) withdraw Landlord’s Termination Notice by written notice given to Tenant
(“Landlord’s Withdrawal Notice”). If, within ten (10) business days after delivery of Landlord’s Withdrawal Notice, Tenant delivers a written notice to Landlord in which Tenant elects to accept Landlord’s
withdrawal of Landlord’s Termination Notice, the Lease shall continue, without modification, through the Term Expiration Date (as the same may be extended pursuant to Section 13 below). If Tenant does not deliver a written notice accepting
Landlord’s withdrawal of Landlord’s Termination Notice as provided in the foregoing sentence, this Lease shall terminate on Landlord’s Early Termination Date as if Landlord’s Early Termination Date were the Term Expiration Date
hereof 
 12. Right of First Offer for Additional Premises. If Landlord desires to lease all or any portion of the
premises described in the “Plans of First Offer Space” attached hereto as Exhibit 2 to any third party, Landlord shall first offer to lease such space (the “Offered Space”) to Tenant at the Expansion Market
Rent (defined below) and except as otherwise specified herein on the same terms and conditions as this Lease, provided, however, that (a) Tenant must lease the Offered Space for at least a three (3) year term, and (b) the Offered
Space shall be leased by Tenant in its “as is” condition. If at the time Tenant wishes to lease the Offered Space the remaining portion of the Term is less than three (3) years, then Landlord shall offer to extend the Term (which
extension will be applicable to the Premises and the Offered Space) so that the Term Expiration Date occurs at least three (3) years after Tenant leases the Offered Space and the Annual Fixed Rent for the Premises after the originally scheduled
Term Expiration Date shall be at the Expansion Market Rent determined under this Section 12. Such extension offer shall be in addition to, and not in lieu of, the extension option set forth in Section 13 below. Any tenant or occupant of
the Offered Space from time to time, any affiliate thereof, or any party having a right (including right of first offer) to lease such space as of the date hereof shall not be considered a “third-party” for purposes of this
Section 12, and Landlord shall be free to lease the Offered Space to any of the foregoing without offering the same to Tenant. Any offer by Landlord to lease all or a portion of the Offered Space shall be accompanied by Landlord’s good
faith determination of the Expansion Market Rent and other terms and conditions. 
 Any offer by Landlord under this
Section 12 may he accepted by Tenant by written notice given within fifteen (15) business days of delivery of Landlord’s offer. Landlord agrees to meet with Tenant, if Tenant requests such meetings, at least twice during such fifteen
(15) business day period at reasonable, mutually agreed upon times during business days to discuss such offer. If Tenant fails to timely accept Landlord’s offer, such offer shall be deemed conclusively waived by Tenant, and Landlord shall
have no further obligation to offer the Offered Space to Tenant nor shall Tenant have any further right to lease the same under this Section 12 so long as (i) Landlord enters into a tease agreement with respect to the Offered Space within
one hundred twenty (120) days after the date that Landlord offered to lease the

  

 6 

 
Offered Space to Tenant and (ii) the net effective rental rate thereunder is at least ninety percent (90%) of the net effective rental rate in Landlord’s offer to Tenant. If
Landlord desires to offer the Offered Space at a net effective rental rate less than ninety percent (90%) of the net effective rental rate in Landlord’s offer to Tenant, or does not lease the Offered Space within such one hundred twenty
(120) day period, then the right of first offer in this Section 12 shall again apply to the Offered Space, and Landlord may not lease it without again complying with the provisions hereof. In the event that Tenant accepts any offer by
Landlord under this section, the leasing of such Offered Space shall be documented by an Amendment to the Lease. Tenant’s rights under this Section 12 shall be rendered void, at Landlord’s election, if Tenant is in default (subject to
any applicable notice and cure periods) at the time Tenant notifies Landlord of its interest in leasing the applicable portion of the Offered Space or at the time Tenant’s lease of any Offered Space under this Section 12 would otherwise
commence. 
 “Expansion Market Rent” shall mean ninety five percent (95%) of the then prevailing market
rate for a three (3) year lease of biotech and office space in the Greater Boston, Massachusetts “Metro-West” area comparable to the Premises in terms of location within a building, finish, age, building quality and amenities for a
tenant of equal size and financial strength as Tenant, under terms and conditions substantially the same as those of this Lease as though then available for single occupancy for the Permitted Uses (or any higher and better use then being made by
Tenant) in “as-is” condition or such better condition in which Tenant is required to maintain the Premises. 
 If
Tenant exercises its rights under this Section 12, Landlord shall use reasonable efforts to deliver the Offered Space as set forth in Landlord’s offer. Landlord’s failure to deliver, or delay in delivering, all or any part of the
Offered Space by reason of Force Majeure, and including continued occupancy of any such Offered Space by any occupant thereof, shall not give rise to any liability of Landlord, shall not alter Tenant’s obligation to accept such Offered Space
when delivered, shall not constitute a default of Landlord, and shall not affect the validity of the Lease; provided that if delivery of the Offered Space does not occur within sixty (60) days after the delivery date set forth in
Landlord’s Offer, Tenant may elect to withdraw its exercise of its rights under this Section 12 by notice given within five (5) business days after the expiration of such sixty (60) day period. If Tenant so notifies Landlord,
Landlord shall have no further obligation to offer the Offered Space to Tenant nor shall Tenant have any further right to lease the same under this Section 12 so long as (i) Landlord enters into a lease agreement with respect to the
Offered Space within one hundred twenty (120) days after the date that Tenant notifies Landlord of its election to withdraw its exercise of its rights under this Section 12 and (ii) the net effective rental rate thereunder is at least
ninety percent (90%) of the net effective rental rate in Landlord’s offer to Tenant. If Landlord desires to offer the Offered Space at a net effective rental rate less than ninety percent (90%) of the net effective rental rate in
Landlord’s offer to Tenant, or does not lease the Offered Space within such one hundred twenty (120) day period, then the right of first offer in this Section 12 shall again apply to the Offered Space, and Landlord may not lease it
without again complying with the provisions hereof. 
 This Section 12 shall not be construed to grant to Tenant any rights
or interest in any space in the Building and any claims by Tenant alleging a failure of Landlord to comply herewith shall be limited to claims for monetary damages and Tenant may not assert any rights in any space nor file any lis pendens or similar
notice with respect thereto. 
  

 7 

 Tenant’s rights under this Section 12 are personal to Tenant and shall not apply
to any Transferee of Tenant (other than a Transferee under a transfer permitted by the second sentence of Section 5.8). If at any time during the Term Tenant has transferred any portion of the Premises (not including transfers permitted
by the second sentence of Section 5.8), then Tenant’s rights under this Section 11 shall be null and void and of no further force or effect. 
 13. Extension Option. 
 (a) Tenant shall have the option to extend the Term
for one (1) additional five (5) year extension term (the “Extension Term”) by notice given to Landlord at least ten (10) months before the Term Expiration Date. Tenant’s election shall be exercised, and Annual
Fixed Rent for the Extension Term determined, as set forth below. If Tenant fails timely to exercise its option for the Extension Term, Tenant shall have no further extension rights hereunder. 
 (b) Tenant’s option so to extend the Term shall be void, at Landlord’s election, if Tenant is in default (subject to any
applicable notice and cure periods) at the time Tenant elects to extend the Term or at the time the Term would expire but for such extension. The extension of the Term shall be applicable to the entire Premises and Tenant shall have no right to
extend the Term for only a portion of the Premises. During the Extension Term, if any, all provisions of the Lease shall apply except that Tenant shall have no further option to extend the Term after the Extension Term. 
 (c) During the Extension Term, Tenant shall pay Annual Fixed Rent equal to ninety five percent (95%) of the then prevailing market rate
for a five (5) year lease of biotech and office space in the Greater Boston, Massachusetts “Metro-West” area comparable to the Premises in terms of location within a building, finish, age, building quality and amenities for a tenant
of equal size and financial strength as Tenant, under terms and conditions substantially the same as those of this Lease as though then available for single occupancy for the Permitted Uses (or any higher and better use then being made by Tenant) in
“as-is” condition or such better condition in which Tenant is required to maintain the Premises (the “Fair Market Rent”). 
 (d) Landlord shall notify Tenant of its estimate of the Fair Market Rent within ten (10) days after Tenant exercises the applicable extension option. Tenant shall within fifteen (15) business
days following delivery of such estimate: (i) accept such estimate, (ii) elect to have the Fair Market Rent determined as provided in Section 13(e) below, or (iii) withdraw its exercise of the extension option; provided, that
Tenant’s failure to respond within such fifteen (15) business day period shall be deemed to be an election to have the Fair Market Rent determined as provided in Section 13(e) below. Landlord agrees to meet with Tenant, if Tenant
requests such meetings, at least twice during such fifteen (15) business day period at reasonable, mutually agreed upon times during business days to discuss Landlord’s Fair Market Rent determination. 
 (e) If Tenant elects (or is deemed to have elected) to have Fair Market Rent determined as provided in this Section 13(e), each of
Landlord and Tenant, within twenty (20) days after the date of such election (or deemed election), shall appoint as an arbitrator an MAI appraiser with at least ten (10) years experience as an appraiser of office buildings in the Greater
Boston area, including first class suburban office buildings, and shall give notice of such appointment to the other party. If either Landlord or Tenant shall fail timely to appoint an

  

 8 

 
arbitrator, the other may apply to the Boston office of the American Arbitration Association (“AAA”) for appointment of such an arbitrator five (5) business days after
notice of such failure to the delinquent party if such arbitrator has not then been appointed. The two arbitrators shall, within five (5) business days after appointment of the second arbitrator, appoint a third arbitrator who shall be
similarly qualified. If the two arbitrators are unable to agree timely on the selection of the third arbitrator, then either arbitrator on behalf of both may request such appointment from the Boston office of the AAA. The arbitration shall be
conducted in accordance with the commercial arbitration rules of the AAA insofar as such rules are not inconsistent with the provisions of this Lease (in which case the provisions of this Lease shall govern). The arbitrators shall be charged to
reach a majority written decision in accordance with the standards for the Fair Market Rent as provided in this Section, within twenty (20) days after the third arbitrator is appointed, by selecting either of the final estimates of the Fair
Market Rent provided by Landlord and Tenant at the commencement of the hearing. The arbitrators shall have no authority or jurisdiction to make any other determination of such amount. The cost of the arbitration (exclusive of each party’s
witness and attorneys fees, which shall be paid by such party) shall be borne equally by the parties. If the AAA shall cease to provide arbitration for commercial disputes in Boston, the second or third arbitrator, as the case may be, shall be
appointed by any successor organization providing substantially the same services, and in the absence of such an organization, by a court of competent jurisdiction under the arbitration act of The Commonwealth of Massachusetts. 
 (f) If Landlord should delay in giving the notice which begins the valuation procedures of this Section, or if the process should otherwise
be delayed for any reason, then such procedures shall nevertheless remain in effect and be applicable when and as invoked with respect to Annual Fixed Rent payable during the Extension Term; but until such procedures are completed, Tenant shall pay
on account of Annual Fixed Rent at the rate established for Annual Fixed Rent for the last twelve (12) months of the Term (and upon Fair Market Rent being established, Tenant shall pay the same within twenty (20) days of such
determination, retroactively to the beginning of the Extension Term). Each party shall bear the costs of the arbitrator selected by it and shall share equally in the costs of the third arbitrator selected in accordance herewith. The parties shall
adjust for over or under payments within twenty (20) days after the decision of the arbitrators is announced. 
 (g)
Promptly after the Annual Fixed Rent is determined for the Extension Term, Landlord and Tenant shall enter into an amendment of the Lease confirming the extension of the Term and the new rate for Annual Fixed Rent. 
 14. Signage. Tenant has the right, at its sole cost and expense, to install and maintain signage (i) consistent with
Tenant’s signage in the Building as of the date of this Second Amendment and that of any other subtenants on the Building lobby directory and on the first and third floor entrances to the Premises and (ii) on a portion of the monument sign
equal in size to its pro rata share of the Building based on the square footage of the Premises. 
 15. Direct Lease.
Upon request of Landlord in connection with Landlord’s prospective transfer or financing of the Building, Tenant will enter into an Amended and Restated Lease upon the same terms as the Lease, but contained in a single document. 
  

 9 

 16. Notification. Any notice, approval, consent and other like communication
hereunder from Landlord to Tenant or from Tenant to Landlord shall be effective only if given in writing and shall be deemed duly delivered if (i) hand delivered, (ii) mailed by prepaid certified or registered mail, return receipt
requested, or (iii) delivered by a national overnight delivery service, receipt confirmed. If requested, Tenant shall send copies of all such notices in like manner to Landlord’s mortgagees and any other persons having an interest in the
Premises and designated by Landlord. Any notice so addressed shall be deemed duly delivered on the third (3rd) business day following the day of mailing if so mailed by registered or certified mail, return receipt requested, whether or not
accepted, or on the date of delivery if hand delivered or sent by overnight delivery service. Communications to Tenant shall be addressed to President and CEO – Pieter Muntendam. Communications to Landlord shall be addressed to P. 0. Box 549249
c/o 225 Wyman Street, Waltham, Massachusetts 02454-9249, Attention: Real Estate Manager, and a copy of all notices shall be sent to Landlord’s attorneys, Chief Legal Officer, Hobbs Brook Management LLC, P.O. Box 54929, Waltham, Massachusetts
02454-9249 and Richard D. Rudman, Esq., DLA Piper LLP (US), 33 Arch Street, 26th Floor, Boston, Massachusetts 02110. Either party may from time to time designate other addresses within the continental United States by notice to the other.

 17. Tenant’s Representative. Tenant’s Representative under Section 8.14 of the Lease is
President and CEO – Pieter Muntendam. 
 18. Brokerage. Landlord and Tenant each represent and warrant to the other
that it has had no dealings with any broker or agent in connection with this Second Amendment or the negotiation hereof, except Richards Barry, Joyce and Partners, LLC and Wyman Street Advisors (the “Brokers”). Landlord and Tenant
each covenant to defend (by counsel reasonably acceptable to the other party), pay, hold harmless and indemnify the other from and against any and all costs, expense or liability for any compensation, commissions, and charges claimed by any broker
or agent, with respect to this Second Amendment or the negotiation thereof arising from a breach of the foregoing warranty. Landlord shall pay all commissions or other brokerage fees and compensation due to Brokers by separate agreement with
Landlord in connection with this Second Amendment. 
 19. Ratification. Except as set forth herein, the terms of the
Lease are hereby ratified and confirmed. 
 20. Miscellaneous. Except as modified herein, the Lease and all of the terms
and provisions thereof shall remain unmodified and in full force and effect as originally written. Tenant’s obligation to pay Annual Fixed Rent and Additional Rent under the Lease shall be absolute, unconditional, and independent and shall not
be discharged or otherwise affected by any law or regulation now or hereafter applicable to the Premises, or any other restriction on Tenant’s use, or, except as expressly provided in the Lease, any casualty or taking, or any failure by
Landlord to perform or other occurrence; and Tenant waives all rights now or hereafter existing to terminate, quit or surrender this Lease or the Premises or any part thereof, or to assert any defense in the nature of constructive eviction to any
action seeking to recover Annual Fixed Rent and Additional Rent, provided, however, that nothing herein shall prevent Tenant from bringing a separate claim for monetary damages or injunctive relief in the event of a Landlord default. In the event of
any conflict or inconsistency between the provisions of the Lease and the

  

 10 

 
provisions of this Second Amendment, the provisions of this Second Amendment shall control. All terms used herein but not defined herein which are defined in the Lease shall have the same meaning
for purposes hereof as they do for purposes of the Lease. The recitals set forth above in this Second Amendment are hereby incorporated by this reference. This Second Amendment shall be binding upon and shall inure to the benefit of the parties
hereto and their respective beneficiaries, successors and assigns. This Second Amendment shall be deemed to have been executed and delivered within The Commonwealth of Massachusetts, and the rights and obligations of Landlord and Tenant shall be
construed and enforced in accordance with, and governed by, the laws of The Commonwealth of Massachusetts. Each party has cooperated in the drafting and preparation of this Second Amendment and, therefore, in any construction to be made of this
Second Amendment, the same shall not be construed against either party. This Second Amendment may be executed in counterparts, and when both Landlord and Tenant have signed and delivered at least one such counterpart, each counterpart shall be
deemed an original, and, when taken together with other signed counterparts, shall constitute one Second Amendment, which shall be binding upon and effective as to Landlord and Tenant. In case any one or more of the provisions contained in this
Second Amendment shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provision of this Second Amendment, and this Second Amendment shall be
construed as if such invalid, illegal or unenforceable provision had never been contained herein. 
 [Signature Pages Follow]

  

 11 

 EXECUTED as a sealed Massachusetts instrument as of the date first written above.

  

			
	LANDLORD:
	
	610 LINCOLN LLC
		
	By:	 	/S/ Donald G. Oldmixon
		 	Name: Donald G. Oldmixon
		 	Title: Manager
	
	TENANT:
	
	BG MEDICINE, INC., a Delaware corporation
		
	By:	 	/S/ Pieter Muntendam
		 	Name: Pieter Muntendam
		 	Title: President & CEO

 EXHIBIT 1 
 Floor Plans of Office Space Premises and Lab Space Premises 
 [GRAPHIC] 

 EXHIBIT 2 
 Plans of First Offer Space on 1st and 3rd Floors 
 [GRAPHIC] 

 EXHIBIT 3 
 Licenses and Services 
 RECEPTION FULLY LOADED FTEs INCLUDING TEMP
COVERAGE 
 MWRA LICENSE FEE - MWRA 
 MWRA TESTING - ANNUAL AND SEMIANNUAL TESTING - GZA 
 MWRA TESTING - SILVER ANALYSIS TESTING - EVOLVE TECHNOLOGIES 
 WASTE NEUTRALIZATION MAINTENANCE EQUIP/PERMIT - GPC BIOTECH 
 PERSONNEL COSTS 
 WASTE NEUTRALIZATION MAINTENANCE - CONTRACT COSTS 
 WASTE NEUTRALIZATION - OPERATOR TRAINING COSTS 
 RODI MAINTENANCE - FLUID SOLUTIONS 
 FACILITY CLEANING - NEW ENGLAND CLEANING 
 FACILITY
CLEANING - SUPPLIES 
 VACUUM SYSTEM MAINTENANCE BUDGET 

 EXHIBIT 4 
 Tenant’s Permitted Hazardous Materials 
 Tenant may store and or
use hazardous materials as needed to operate their business provided the use, and storage of said materials is in all respects, in compliance with all applicable local, state and federal regulations. Provided, however that the use of flammable
materials not exceed the limits set below: 
 Flammable materials as noted: 
  

			
	BG Medicine Flammables	  	Allocation to be stored and used on the third floor.
	Class 1A	  	10 Gallons
	Class 1B	  	35 Gallons
	Class 1C	  	25 Gallons
	Class II	  	100 Gallons
	Class IIIA	  	100 Gallons
	Class IIIB	  	100 Gallons
	Flammable Solids	  	2 Pounds
	Flammable Gases	  	250 Cubic Feet

 EXHIBIT 5 
 Janitorial Specifications for Cleaning of Lab Space Premises 
 1.
LABS AND RELATED AREAS 
 DAILY 
  

	1.	Empty the wastebaskets and replace the plastic liners as needed. 

  

	2.	Spot clean the glass panes on the doors and the partitions. 

  

	3.	Sweep, dry mop or vacuum the resilient tile flooring. 

  

	4.	Spot mop the resilient tile flooring. 

  

	5.	Pick up and discard broken glass. 

  

	6.	Pick up and discard (triple rinsed) reagent bottles in 55 gallon bins in chemistry. 

 SEMI-WEEKLY 
  

	1.	Damp mop the resilient tile flooring. 

  

	2	Spray buff and/or burnish the resilient tile flooring. 

 MONTHLY 
  

	1.	Wash both sides of the glass panes an the doors and the partitions. 

  

	2.	Dust the ceiling corners and other items outside of reach. 

 J. STAIRWAYS 
 DAILY 
  

	1.	Sweep or vacuum the stair treads and the landings. 

  

	2.	Spot mop the stair treads and the landings. 

  

	3.	Vacuum the stair treads and the landings. 

 WEEKLY 
  

	1.	Damp mop the stair treads and the landings. 

  

	2.	Damp wipe the railings, door frames, doors, lighting fixtures, and other items within reach. 

 MONTHLY 
  

	1.	Dust the ceiling corners and other items outside of reach. 

  

 17 

 EXHIBIT 6 
 Janitorial Specifications for Cleaning of Office Space Premises 
 OFFICE AREA 
 Daily/Nightly Monday through Friday, excluding holidays. 
  

	 	•	 	 Empty all waste receptacles and return to proper locations. 

  

	 	•	 	 Sweep and dust mop all uncarpeted areas. 

  

	 	•	 	 Vacuum all rugs and carpeted areas. 

  

	 	•	 	 Dust horizontal surfaces of furniture and equipment within normal reach. 

  

	 	•	 	 Clean and sanitize all drinking fountains and water coolers. 

  

	 	•	 	 Remove finger marks from glass sidelights 

  

	 	•	 	 Wipe Clean all brass and other metal surfaces within normal reach. 

 Clean Tenant kitchen space, (sink, surfaces, and floors with germicide) 
 Monthly: 
 Remove all finger marks from doors, door jambs, and light switches Spot clean tile floor areas where needed 
 Quarterly: 
 Wash interior partition glass surfaces. 
 Dust picture frames, chart boards and similar wall hangings 
 RESTROOMS 
 Daily 
  

	 	•	 	 Sweep and mop floors 

  

	 	•	 	 Clean and sanitize all floors, toilet seats, bowls, urinals and fixtures 

  

	 	•	 	 Clean all mirrors and shelves 

  

	 	•	 	 Refill towel dispensers, tissue holders, materials to be furnished by Landlord. 

  

	 	•	 	 Empty paper towel receptacles 

  

	 	•	 	 Dust all partitions 

 Monthly: 
 Machine scrub restroom floors 
 Wash all partitions, dispensers and splash areas 
 Dust all light fixtures and ventilating grills. 
 Quarterly: 
 Wash all tile walls and partitions. 
 Tenant requiring services in excess of those above shall request through Landlord at Tenant’s expense.

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