Document:

EX-10.11

 Exhibit 10.11 

OFFICE SUBLEASE 

11099 North Torrey Pines Road, San Diego, California 

KEY PROVISIONS SUMMARY 

					
	 Sublease Date:
	  	
May 6, 2014

	 Sublandlord:
	  	
COI PHARMACEUTICALS, INC., a Delaware corporation

	 Subtenant:
	  	
SYNTHORX, INC., a Delaware corporation

	 Premises:
	  	
Approximately 8,636 rentable square feet of space located in Suite 200/230 in the Master Property, more particularly shown on the floor plan
attached hereto as Exhibit B

	 Master Property:
	  	
Those certain premises located in the building having a street address of 11099 North Torrey Pines Road, City of San Diego, California and
being more particularly described in the Master Lease

	 Master Landlord:
	  	
HCP TORREY PINES LLC, a Delaware limited liability company

	 Master Lease:
	  	
Standard Multi-Tenant Office Lease – Net, by and between Master Land, as landlord, and Sublandlord, as tenant, dated May 7, 2013,
as amended by that certain Addendum to Lease dated August 22, 2013, as amended by that certain First Amendment to Multi Tenant – Net Office Lease dated August 22, 2013, as amended by that certain Second Amendment to Multi-Tenant
Office Lease – Net dated September 23, 2014, as amended by that certain Third Amendment to Multi-Tenant Office Lease – Net dated September 14, 2015, as amended by that certain Fourth Amendment to Multi-Tenant Office Lease –
Net dated May 6, 2016, as amended by that certain Fifth Amendment to Multi-Tenant Office Lease – Net dated November 2, 2016, for the lease of the Master Property, attached hereto as Exhibit A

	 Notices:
	  	 Sublandlord:
	  	
Subtenant:

	  	 COI PHARMACEUTICALS,
INC.
	  	
SYNTHORX, INC.

	  	 With a copy
to:
	  	
With a copy to:

	  	 Tighe
Reardon
	  	
Jay B. Lichter, PhD

	 Commencement Date:
	  	
The Sublease Date: May 6, 2014

	Rent Commencement Date:	  	
The Sublease Date (Section 3)

May 6, 2014

	 Expiration Date:
	  	
The Expansion Expiration Date as defined in the Master Lease: February 28, 2027

	 Rent:
	  	
24 % of Sublandlord’s Base Rent (as defined in the Master Lease) under the Master Lease (Section 3)

	 Additional Rent:
	  	
23% of Lessee’s Share of Operating Expenses (as defined in the Master Lease) under the Master Lease (Section 3)

	 Rent Payment Address:
	  	
11099 N Torrey Pines Road, Suite 290, La Jolla, CA 92037

	 Permitted Use:
	  	
The Agreed Use (as defined in the Master Lease) under the Master (Section 5)

	 Security Deposit:
	  	
$ - 0 - (Section 15)

	 Brokers:
	  	
Re:align Tenant Strategies, whose commission(s) to be paid by HCP (Section 10)

	 Exhibits:
	  	
Exhibit A – Master Lease

Exhibit B – Floor Plan of Premises

  
  

Page 1 

 OFFICE SUBLEASE AGREEMENT 

THIS SUBLEASE is made and entered into as of the Sublease Date by and between Sublandlord and Subtenant. 

Recitals 

A.        Sublandlord leases from Master Landlord the Master Property pursuant to the
Master Lease. 
 B.        Subtenant desires to sublease from Sublandlord the
Premises pursuant to the terms hereof. 
 NOW, THEREFORE, in consideration of mutual covenants contained herein and
other good and valuable consideration, the receipt and sufficiency of which is acknowledged, Sublandlord does hereby sublease unto Subtenant and Subtenant hereby subleases from Sublandlord the Premises upon the following terms and conditions: 

1.        Master Lease Terms and Conditions. 

1.1    References in the body of this Sublease to a portion of the Key Provisions Summary (e.g.,
the defined terms in the left-hand column of the Key Provisions Summary) shall be deemed and construed to incorporate all the terms provided under each such referenced portion of the Key Provisions Summary. References in the Key Provisions Summary
to a portion of the body of this Sublease (e.g., Section references in the right-hand column of the Key Provisions Summary) shall be deemed and construed to incorporate all the terms provided under each such referenced portion of the body of the
Sublease. Notwithstanding anything set forth above, if there is any inconsistency between the Key Provisions Summary and another portion of this Sublease, the terms of the Key Provisions Summary shall control. 

1.2    Except as set forth herein, this Sublease is made upon, and shall be subject and subordinate
to, all of the terms, covenants and conditions of the Master Lease and all mortgages, leases and other documents to which the Master Lease is or may hereafter become subject and subordinate. Subtenant shall, upon request, execute certificates
reasonably requested to confirm such subordination. 
 1.3    Subtenant hereby covenants and
agrees (a) to assume, faithfully perform, observe and be bound by all of the terms, covenants, and conditions required to be performed by or on the part of tenant under the Master Lease related to the Premises, all of which shall constitute the
terms of this Sublease, except to the extent such terms are inconsistent with the terms of this Sublease, in which event the terms of this Sublease shall prevail; (b) to indemnify, protect, defend and hold Sublandlord harmless from and against
any and all liabilities, penalties, demands and other costs and expenses (including, without limitation, reasonable attorneys’ fees) incurred under or pursuant to the Master Lease by reason of Subtenant’s failure to fully comply with any
and all of the duties, covenants and obligations of Sublandlord under and pursuant thereto which are required to be performed by tenant pursuant to the terms of the Master Lease; (c) that any default by Master Landlord shall not affect this
Sublease or waive or defer the performance of any of Subtenant’s obligations hereunder; (d) that Subtenant shall not do or cause to be done or suffer or permit any act to be done which would or might cause the Master Lease, or the rights
of Sublandlord as tenant under the Master Lease to be endangered, canceled, terminated, forfeited or surrendered, or which would or might cause Sublandlord to be in default thereunder or liable for any damage, claim or penalty; and (e) to
obtain Sublandlord’s consent whenever Master Landlord’s consent is needed under the Master Lease. 

1.4    Subtenant agrees, as an express inducement for Sublandlord’s execution of this
Sublease, that if there is any conflict between the provisions of this Sublease and the provisions of the Master 

  
  

Page 2 

 
Lease which would permit Subtenant to do or cause to be done or suffer or permit anything to be done which is prohibited by the Master Lease, then the provisions of the Master Lease shall
prevail. Subtenant acknowledges that Sublandlord does not covenant or agree to do or perform any obligations undertaken or assumed by the Master Landlord under the Master Lease and that Master Landlord has responsibility for providing services and
utilities under the terms of the Master Lease. Sublandlord agrees to assist Subtenant in securing the performance of any responsibility of Master Landlord under the terms of the Master Lease. Sublandlord shall maintain the Master Lease in full force
and effect during the Sublease Term provided Sublandlord shall not be liable to Subtenant for any early termination of or default under the Master Lease which is not due to the gross negligence or willful misconduct of Sublandlord. 

2.        Sublease Term. The term of this Sublease shall
begin on the Commencement Date and shall continue until the Expiration Date (the “Sublease Term”). 

3.        Rent. 

3.1        Subtenant shall pay Sublandlord the Rent in twelve (12) equal
monthly installments, in advance, not later than the first day of each calendar month, without notice, deduction, or offset, commencing on the Rent Commencement Date and continuing through the Sublease Term. If the Rent Commencement Date is not the
first day of a calendar month, Rent shall be pro-rated for such short-month and paid not later than the Rent Commencement Date. 

3.2        Checks for all Rent shall be made payable to Sublandlord and mailed
or delivered to the address set forth in the Key Provisions Summary or to such other address as Sublandlord may designate to Subtenant in writing. To defray administrative and handling expenses, Subtenant agrees to pay an additional charge of Fifty
and No/100 Dollars ($50) for each returned check. If any payment of Rent is not received by Sublandlord when due, then Subtenant shall pay Sublandlord the greater of (i) five percent (5%) of the late Rent; or (ii) Two Hundred Fifty and
No/00 Dollars ($250.00). In addition, if any payment of Rent is not received within ten (10) days of when due, such late Rent shall bear interest at the lesser of eighteen percent (18%) per annum, compounded monthly, or the maximum rate
permitted under law (“Interest”), from the due date of such Rent until such Rent and all Interest accrued thereon is paid in full. Subtenant acknowledges that the aforementioned administrative charge, late charge and Interest
are in addition to Sublandlord’s other rights and remedies available under this Sublease, at law or in equity, and that such administrative charge, late charge and Interest shall in no way limit Sublandlord’s other rights and remedies. If
Sublandlord shall at any time accept any such Rent or other sums after the same shall become due and payable, such acceptance shall not excuse a delay upon subsequent occasions, or constitute or be construed as a waiver of any of Sublandlord’s
rights hereunder, at law or in equity. 
 3.3        Sublandlord’s Base
Rent (as defined in the Master Lease) under the Master Lease is subject to annual increases as set forth in the Master Lease. 

3.4        With each payment of Rent, Subtenant shall pay 23% of Lessee’s
Share of Operating Expenses (as defined in the Master Lease) under the Master Lease for the upcoming month. 

4.        Insurance. Subtenant shall, at its sole cost and
expense, maintain throughout the Sublease Term, any insurance coverage required to be maintained by Sublandlord under the Master Lease, pursuant to the terms and conditions of the Master Lease, with a company authorized to transact business in the
jurisdiction where the Premises is located and otherwise in accordance with the terms of the Master Lease. Sublandlord and Master Landlord shall be named as additional insureds under such insurance. Subtenant shall indemnify and save harmless
Sublandlord and Master Landlord from any claim or loss by reason of an accident or damage to any person or property happening in the Premises. Subtenant shall provide Sublandlord and Master Landlord with certificates of insurance evidencing the
insurance be maintained by Subtenant herein. Subtenant 

  
  

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further agrees to give thirty (30) days advance written notice of any cancellation or reduction of insurance under any such policy. Neither Sublandlord nor Subtenant shall be liable to the
other party for damages to the Master Property or the Premises, the improvements located thereon or the contents thereof, to the extent that such liability is coverable by a policy of insurance required to be maintained, or actually maintained, by
the damaged party. Sublandlord and Subtenant hereby grant to one another on behalf of any insurer providing insurance to either covering the Master Property or the Premises, the improvements located thereon or the contents thereof, a waiver of any
right of subrogation any such insurer of one party may acquire against the other by virtue of payment of any loss under any such insurance. The foregoing provision shall be of no force or effect to the extent its existence or enforceability would
adversely affect the enforceability, validity and/or collectability of any insurance coverage claimed by either party provided that both parties agree to obtain any insurance endorsements which may be available at nominal cost if such endorsements
would permit the effectiveness of this provision under circumstances where it would otherwise be ineffective. If a party is unable to obtain such endorsement, it shall immediately notify the other of this inability. In the absence of such
notification, each party shall be deemed to have obtained such waiver of subrogation. 

5.        Use and Compliance With Laws. Subtenant shall
(a) use the Premises for the Permitted Use only and for no other purpose; (b) not conduct on the Premises nor permit to be conducted on the Premises any business which is in violation of federal law, the laws of the State in which the
Premises is located or any law or ordinance of any political subdivision having jurisdiction over the Premises: (c) maintain the Premises in compliance with “tenant’s” maintenance requirements under the Master Lease; and
(d) not, without compliance with applicable rules, regulations and ordinances, generate, store, treat or dispose of any hazardous materials (as defined in the Master Lease) or otherwise breach any of the representations regarding hazardous
materials contained in the Master Lease or this Sublease and shall promptly notify Sublandlord of any written allegation of non-compliance received by Subtenant. Without limiting any other indemnification set
forth in this Sublease, Subtenant shall indemnify, protect, defend and hold Sublandlord and Master Landlord harmless from and against any and all damages, liabilities, judgments, costs, claims, liens, expenses, penalties, suits, demands, actions,
fines, and all costs and expenses thereof (including, without limitation, reasonable attorneys’ and consultants’ fees) arising out of or involving any hazardous materials introduced to the Premises by Subtenant or at Subtenant’s
direction or any other violation of any applicable environmental laws by Subtenant or its agents. This provision shall survive the expiration or earlier termination of the Sublease Term. No termination, cancellation or release agreement entered into
by Sublandlord or Master Landlord and Subtenant shall release Subtenant from its obligations under this Sublease with respect to all applicable environmental laws unless specifically so agreed by Sublandlord and Master Landlord in writing at the
time of such agreement. This provision shall survive the expiration or early termination of this Sublease. 

6.        Alterations. Subtenant has examined the Premises
and accepts the Premises in an “AS IS” “WHERE IS” “WITH ALL FAULTS” condition, and Subtenant acknowledges and agrees that neither Sublandlord nor any of Sublandlord’s agents, employees or
representatives have made any representation or warranty, either express or implied, with respect to the Premises or the use thereof by Subtenant. Subtenant shall not make any alterations to the Premises without Sublandlord’s and Master
Landlord’s, as may be required, prior written consent. If any alterations are permitted, Subtenant shall comply with all requirements of the Master Lease with respect to such alterations, including, but not limited to, mechanics’ liens and
bonding. Any alterations made, other than the installation of Subtenant’s personal property, shall remain on and be surrendered with the Premises on the expiration or earlier termination of the Sublease Term, unless such alterations are
required to be removed pursuant to the terms of this Sublease or Sublandlord requires Subtenant to remove such alterations, in which case Subtenant shall, at its own cost, remove such alterations and repair any damage caused by such removal. 

7.        Indemnification. Subtenant shall indemnify,
protect, defend and hold Sublandlord and Master Landlord harmless from and against any and all damages, liabilities, judgments, costs, claims, liens, expenses, penalties, suits, demands, actions, fines, and all costs and expenses thereof (including,
without limitation, 

  
  

Page 4 

 
reasonable attorneys’ and consultants’ fees) arising out of or involving the use or occupancy of the Premises by Subtenant, its agents, contractors, employees, invitees, licensees,
servants, subcontractors or subtenants, except to the extent caused by the gross negligence or willful misconduct of Sublandlord. 

8.        Default. The occurrence of one or more of the
following events (herein “Events of Default”) shall constitute a default by Subtenant and a breach of this Sublease: (a) the filing of a petition by Subtenant for adjudication as bankrupt, the involuntary adjudication of
Subtenant as bankrupt or the voluntary reorganization of Subtenant pursuant to the United States Bankruptcy Code; (b) the appointment of a receiver for Subtenant; (c) the making by Subtenant of any assignment for the benefit of creditors;
(d) the failure to pay rent within three (3) days after same becomes due or the failure to maintain the required insurance coverages to be maintained by Subtenant hereunder; (e) a default in the performance of any other covenant or
condition of this Sublease on the part of Subtenant not cured within five (5) days of Sublandlord’s notice thereof (except no notice shall be required for Sublandlord to commence to cure Subtenant’s default in the event of an
emergency or if required under the Master Lease); and (f) any other act or omission which would constitute a default under the terms of the Master Lease. 

9.        Sublandlord’s Remedies On Default By
Subtenant. Upon the occurrence of an Event of Default, Sublandlord shall have the right to terminate this Sublease and/or Subtenant’s right to possession of the Premises at any time and reenter the Premises. In addition,
Sublandlord shall have the right to pursue any and all other remedies available at law and in equity to recover from Subtenant all amounts then due or thereafter accruing and such other damages as are caused by Subtenant’s Event of Default. No
course of dealing between Sublandlord and Subtenant or any delay on the part of Sublandlord in exercising any rights Sublandlord may have under this Sublease shall operate as a waiver of any of the rights of Sublandlord hereunder nor shall any
waiver or prior default operate as a waiver of any subsequent default. In exercising its rights and remedies under this Sublease, Sublandlord shall be entitled to recover from Subtenant all costs incurred, including, without limitation, reasonable
attorneys’ fees. 
 10.        Brokers. Sublandlord
and Subtenant warrant that they have not used any broker other than Broker, if any, and each party agrees to indemnify, protect, defend and hold each other harmless from and against any and all damages, liabilities, judgments, costs, claims, liens,
expenses, penalties, suits, demands, actions, fines, and all costs and expenses thereof (including, without limitation, reasonable attorneys’ and consultants’ fees) for brokerage commissions arising out of or involving each other’s
actions in connection with this Sublease, including the payment of any commission or any other fee or charge due to any other broker having a claim through such party. 

11.        Assignment and Subletting. Subtenant shall not
further sublet all or any portion of the Premises to others or assign or encumber this Sublease without the prior written consent of Sublandlord. Consent by Sublandlord to one assignment or subletting shall not destroy or operate as a waiver of the
prohibitions contained in this paragraph or in the Master Lease as to future assignments or subleases, and all such later assignments or subleases shall be made only with the prior written consent of Sublandlord. In the event an assignment or
encumbrance of this Sublease or subletting of the Premises or any part thereof is made by Subtenant, Subtenant shall remain liable to Sublandlord for payment of all rent provided for hereunder and for the faithful performance of all the covenants
and conditions contained herein to the same extent as if this Sublease had not been assigned or encumbered or the Premises sublet. If Subtenant sublets the Premises at a rental that exceeds all rentals to be paid to Sublandlord hereunder, Subtenant
shall pay over any such excess to Sublandlord. Subtenant shall pay to Sublandlord a fee of $1,500 for Sublandlord’s review of a request for consent to assign, encumber, or sublet. 

12.        Entry. Master Landlord and Sublandlord shall
have the same rights to enter into the Premises as are provided to Master Landlord to enter the Master Property in the Master Lease. 

  
  

Page 5 

 13.        Holding
Over. Subtenant shall have no right to occupy the Premises or any portion thereof after the expiration of this Sublease or after termination of this Sublease or of Subtenant’s right to possession in consequence of an Event of
Default hereunder. If Subtenant or any party claiming by, through or under Subtenant holds over, Sublandlord may exercise any and all remedies available to it at law or in equity to recover possession of the Premises, and to recover damages,
including, without limitation, damages payable by Sublandlord to Master Landlord by reason of such holdover. For each and every month or partial month that Subtenant or any party claiming by, through or under Subtenant remains in occupancy of all or
any portion of the Premises after the expiration of this Sublease or after termination of this Sublease or Subtenant’s right to possession, Subtenant shall pay, as minimum damages and not as a penalty, monthly rent at a rate equal to double the
rate of monthly Rent and Additional Rent payable by Subtenant hereunder immediately prior to the expiration or other termination of this Sublease or of Subtenant’s right of possession. The acceptance by Sublandlord of any lesser sum shall be
construed as payment on account and not in satisfaction of damages for such holding over. 

14.        Limitation of Liability. Subtenant agrees that
Subtenant shall look solely to the interest of Sublandlord in the Premises for the collection of any judgment requiring the payment of money by Sublandlord for any default or breach under this Sublease. 

15.        Security Deposit. As an express condition of
the Sublease, Subtenant shall deposit with Sublandlord the Security Deposit, which shall be held during the Sublease Term by Sublandlord to guarantee the faithful performance by Subtenant of its obligations as provided in this Sublease. The Security
Deposit or any portion thereof may be applied to the curing of any default that may then exist, without prejudice to any other remedy or remedies which Sublandlord may have on account thereof, and upon such application Subtenant shall pay
Sublandlord on demand the amount so applied which shall be added to the Security Deposit so the same may be restored to its original amount. Unless prohibited by law, Sublandlord or its successor may commingle the Security Deposit with its other
funds. Upon termination of this Sublease, and provided Subtenant is not in default hereunder and has performed all of its obligations under this Sublease, Sublandlord shall return the remainder of Security Deposit, without any interest thereon, to
Subtenant. Subtenant covenants and agrees that it will not assign, pledge, hypothecate, mortgage or otherwise encumber the aforementioned security during the Sublease Term. 

16.        Notice. 

16.1    Written Notice; Delivery Methods. Each party giving or making any
notice, request, demand, consent, approval, or other communication (each, a “Notice” (but sometimes “notice”)) pursuant to this Sublease shall: (i) give the Notice in writing; (ii) cause the
Notice to be signed by an authorized officer of the sending party; and (iii) use one of the following methods of delivery, each of which for purposes of this Sublease is a writing: (a) personal delivery; (b) Registered or Certified
Mail, in each case, return receipt requested and postage prepaid; (c) nationally recognized overnight courier, with all fees prepaid; or (d) facsimile (but only if a party’s fax number is included in its notice address in the Key
Provisions Summary). 
 16.2    Addresses. Each party giving a Notice shall
address the Notice to the appropriate person at the receiving party (the “Addressee”) at the addresses listed in the Notice Addresses section of the Key Provisions Summary or to another Addressee or at another address as
designated by a party in a Notice pursuant to this Section 16. 

16.3    Effectiveness of a Notice. Except as provided elsewhere in this Sublease, a Notice
is effective only if the party giving the Notice has complied with Sections 16.1 and 16.2 above and if the Addressee has received the Notice. A Notice is deemed to have been received as follows: (i) if a Notice is delivered in
person, or sent by Registered or Certified Mail, or nationally recognized overnight courier, upon receipt as indicated by the date on the signed receipt; (ii) if a Notice is sent by facsimile, upon receipt by the

  
  

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party giving the Notice of an acknowledgment or transmission report generated by the machine from which the facsimile was sent indicating that the facsimile was sent in its entirety to the
Addressee’s facsimile number; and (iii) if the Addressee rejects or otherwise refuses to accept the Notice, or if the Notice cannot be delivered because of a change in address for which no Notice was given, then upon the rejection,
refusal, or inability to deliver the Notice. In addition, if a Notice is sent by facsimile, the party sending the Notice shall also send a confirmation copy of the Notice by one of the methods set forth in Section 16.3(i)
above. 
 16.4    Delivery Time of Notice. Notwithstanding the foregoing,
if any Notice is received after 5:00 p.m. on a Business Day where the Addressee is located, or on a day that is not a Business Day where the Addressee is located, then the Notice is deemed received at 9:00 a.m. on the next Business Day where the
Addressee is located. Each party’s attorney is authorized to give any Notice pursuant to this Sublease on behalf of such attorney’s client. 

17.        Jurisdiction. The parties hereto agree that
this Sublease and the enforcement hereof shall be construed in accordance with and governed by the laws of the State in which the Premises is located and that any action brought under this Sublease shall be brought in the state courts. 

18.        Corporate Authority. Subtenant and each person
executing this Sublease on behalf of Subtenant represents and warrants that Subtenant is validly existing under the laws of their state of domicile and that Subtenant has full right and authority to enter into this Sublease and to perform all of
Subtenant’s obligations hereunder. 
 19.        Integration and
Binding Effect. The entire agreement between Sublandlord and Subtenant is contained in the provisions of this Sublease and any stipulations, representations, promises or agreements, written or oral made prior to or contemporaneous
with this Sublease shall have no legal effect unless contained herein. In the event Sublandlord retains an attorney to enforce provisions of this Sublease, Sublandlord shall be entitled to recover, in addition to all other remedies available at law
or in equity, its reasonable attorneys’ fees from the Subtenant. Titles to the paragraphs of this Sublease shall be ignored when interpreting this Sublease. This Sublease shall be binding upon and inure to the benefit of the parties hereto,
their respective heirs, successors and assigns. Any amendments to this Sublease must be made in writing and executed by the party to be charged with such amendment. 

20.        Certification. Subtenant certifies that:
(i) it is not acting, directly or indirectly, for or on behalf of any person, group, entity, or nation named by any Executive Order or by the U.S. Treasury Department as a terrorist, a “Specially Designated National and Blocked
Person,” or any other banned or blocked person, entity, nation, or transaction pursuant to any law, order, rule, or regulation that is enforced or administered by the Office of Foreign Assets control; and (ii) it is not engaged in this
transaction directly or indirectly on behalf of, or instigating or facilitating this transaction directly or indirectly on behalf of, any such person, group, entity, or nation. Tenant shall indemnify, defend, and hold harmless Sublandlord from and
against any and all claims, damages, losses, liabilities, costs, expenses, and fines, including but not limited to reasonable attorneys’ fees, witness fees, and court costs actually incurred, arising out of or related to any breach of the
foregoing certification. 
 21.        Attorneys’
Fees. In the event of any litigation related to this Sublease, whether to enforce its terms, recover for default, or otherwise, if either party receives a judgment, settlement, or award in its favor (the “Receiving
Party”) against the other party (the “Paying Party”) in such litigation, the Paying Party will pay upon demand all of the Receiving Party’s costs, charges, and expenses (including but not limited to
reasonable attorneys’ fees, court costs, and expert witness fees) arising out of such litigation (including the costs of any appeal related thereto); provided, however, that if prior to commencement of a trial in the litigation the Paying Party
offers to pay an amount equal to or in excess of such judgment, settlement, or award, the Receiving Party shall not be entitled to any such costs, charges, expenses, or attorneys’ fees. 

  
  

Page 7 

 IN WITNESS WHEREOF, the parties hereto have executed this Office
Sublease Agreement as of the day and year first above written. 
  

	
	 Sublandlord

	
	 COI PHARMACEUTICALS, INC.,

a Delaware corporation

	
	 By: /s/ Tighe
Reardon                                    

	
	 Print Name: Tighe Reardon

	
	 Title: Chief Financial Officer

	
	 Date: August 28,
2017                                  

	
	 Subtenant

	
	SYNTHORX, INC.
	 A Delaware corporation

	
	 By: /s/ Jay B. Lichter,
PhD                          

	
	 Print Name: Jay B. Lichter, PhD

	
	 Title: President & Chief Executive Officer

	
	 Date: August 28, 2017

  
  

Page 8 

 EXHIBIT A 

MASTER LEASE 

 EXHIBIT B 

FLOOR PLANEX-10.12

 Exhibit 10.12 

 
 

 
 October 15, 2017 

Laura Shawver, Ph.D. 
 7135 Fay 

La Jolla, CA 92037 
  

					
	VIA ELECTRONIC MAIL	  		  	CONFIDENTIAL

 lshawver@cleavebio.com 

Dear Laura, 
 We are very
pleased to extend to you the offer of employment for the position of President and Chief Executive Officer. You will also serve as a Director on the Board of Directors of Synthorx, Inc. 

The following outlines your offer of Employment: 
  

			
	 Start Date:
	  	 On November 27, 2017; we understand that you might need to transition out of Cleave and so we would accommodate a
fractional position up to 6 months.

		
	 Compensation:
	  	 Your semi-monthly salary in the amount of $18,750.00 will be paid to you on the 15th and on the last day of each
month, less all standard payroll deductions and withholdings, in accordance with the Company’s normal payroll practices; should the 15th or the last day of the month fall on a weekend day or holiday, then payment would be made on the last
business day prior to the weekend or holiday.

		
	 Relocation Fee:
	  	 The Company will reimburse you for relocation expenses up to Ten thousand dollars ($10,000.00). In the event that you
terminate your employment with the Company for any reason before 12 months, you then agree to repay in-full the amount back to the company prior to your departure.

 11099 N. Torrey Pines Road, Suite 290, La Jolla, CA 92037 

Main: (858) 750-4700    Fax: (858) 750-4701

			
	Sick Time Policy:	  	 As of your date of employment, you will be eligible to accrue sick time at a rate of 3.33 hours per month, up to a maximum
of five days per year.

		
	Company Benefits:	  	 You will be eligible to participate in the company’s Medical, Dental, Vision, Life, AD&D, STD, LTD and 401(k)
plans (the “Benefit Plans”). Your participation in any such Benefit Plans will be governed by the terms and conditions of such plans and the Company will have the right to amend or terminate any such Benefit Plans in its sole
discretion.

		
	Annual Bonus:	  	 You will be eligible to receive a target bonus payment of thirty-five percent (35%) of your annual salary payable at the
end of each calendar year, beginning in 2018. Such bonus would be contingent upon successful achievement of agreed upon objectives between you and the Company.

		
	Performance/Merit	  	
	Review:	  	 Annually

		
	Equity Incentive Plan:	  	
		
		  	 It is contemplated that you will be granted an option to purchase, pursuant to Synthorx’s equity incentive plan, a
number of shares of Synthorx’s common stock equal to 5% of Synthorx’s post Series B financing fully diluted capitalization. Such option grant shall be made at a purchase price per share equal to the fair market value of
Synthorx’s common stock on the date of grant as determined by Synthorx’s Board of Directors and will vest as follows: 25% of the shares subject to the option will vest on the one year anniversary of the vesting commencement date and the
remaining shares will vest in equal monthly installments over the next 36 months.

		
	Severance:	  	 In the event your employment with the Company is terminated by the Company not for Cause1 subject to

  

 
 1 “Cause” means any of the following: (i) your material breach of any agreement between you and the Company, including but not limited to a breach of any confidentiality
agreement or invention assignment agreement between you and the Company; (ii) your ongoing and repeated failure or refusal to perform or neglect of your lawful duties; (iii) your engaging in any act of dishonesty, fraud or misrepresentation; (iv)
your violation of any federal or state law or regulation applicable to the business of the Company or its affiliates; or (v) your being convicted of, or entering a plea of nolo contendere to, any crime or committing any act of moral turpitude.

			
		  	 your execution of a release of claims acceptable in form and substance to the Company, the Company will continue to pay you
normal salary payments for a period of six (6) months, less all standard payroll deductions and withholdings, in accordance with the Company’s normal payroll practices.

 This offer of employment is at will, meaning, you may terminate your employment with the Company at any time
and for any reason. Likewise, the Company may terminate your employment at any time, with or without cause or advance notice.    As a condition of employment, you must read, sign and comply with the attached Employee Proprietary
Information and Inventions Assignment Agreement which prohibits unauthorized use or disclosure of Company proprietary information.    This offer is contingent upon the company acquiring satisfactory references from the list that
you have provided. 
 Federal law requires all companies to verify U.S. work authorization upon date of hire. Therefore, please bring your
documents verifying identity and work authorization, i.e. passport, or driver’s license, and your social security card or birth certificate with you on your first day. If you do not have these documents, please contact my office prior to your
start date. 
 To formally respond and accept this offer, please sign below and return to the Company by Friday, October 20, 2017. We
look forward to your acceptance of this offer and to a mutually rewarding relationship. This letter sets forth all the material terms of our offer of employment, and it supersedes all prior offers, agreements and discussions about employment that
you may have had with any employee of the Company, whether written or oral. The terms of this employment offer cannot be modified or amended by any Company employee, or by any action of the Company or any of its affiliated entities, unless made in
writing, signed by both you, the Company’s CEO, and approved by the board of directors. 
 Very truly yours, 

/s/ Jay B. Lichter, PhD 
 Jay B. Lichter,
PhD     
 Interim Chief Executive Officer     

 

			
	 Accepted by: /s/ Laura
Shawver                                
	  	 Date:
10/19/17

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