Document:

exv10w41

 

EXHIBIT 10.41

SGX Pharmaceuticals, Inc.

2005 Equity Incentive Plan

Restricted Stock Unit Grant Notice 

SGX Pharmaceuticals, Inc. (the “Company”), pursuant to Section 7(c) of its 2005 Equity
Incentive Plan (the “Plan”), hereby awards to you as a Participant under the Plan a Restricted
Stock Unit for the number of shares of the Company’s Common Stock set forth below (the “Award”).
This Award is subject to all of the terms and conditions as set forth herein and in the applicable
Restricted Stock Unit Agreement and the Plan, both of which are attached hereto and incorporated
herein in their entirety.

	 	 	 
	Participant:
	 	 
	 

	 	 
	Date of Grant:
	 	 
	 

	 	 
	Number of Shares subject to the Award:
	 	 
	 

	 	 
	Consideration:

	 	Participant’s services to the Company
	 

	 	 

Vesting Schedule: The shares subject to this Award will vest in accordance with the following
schedule, provided that the vesting will cease upon the termination of Participant’s Continuous
Service:

Additional Terms/Acknowledgements: The undersigned Participant acknowledges receipt of, and
understands and agrees to, this Restricted Stock Unit Grant Notice, the Restricted Stock Unit
Agreement and the Plan. Participant further acknowledges that as of the Date of Grant, this
Restricted Stock Unit Grant Notice, the Restricted Stock Unit Agreement and the Plan set forth the
entire understanding between Participant and the Company regarding the acquisition of Restricted
Stock Units of the Company and supersede all prior oral and written agreements on that subject with
the exception of (i) Stock Awards previously granted and delivered to Participant under the Plan,
and (ii) the following agreements only:

	 	 	 
	Other Agreements:
	 	 
	 

	 	 
	 
	 	 
	 

	 	 

 

 

	 	 	 	 	 	 	 
	Participant	 	SGX Pharmaceuticals, Inc. 
	 
	 	 	 	 	 	 
	 

	 	 	 	By:	 	 
	 	 	 	 	 
	 

	 	Signature
	 	 	 	Signature
	 
	 	 	 	 	 	 
	Name:

	 	 	 	Name:	 	 
	 

	 	 
	 	 	 	 
	 

	 	Print
	 	 	 	Print
	 
	 	 	 	 	 	 
	Date:

	 	 	 	Title:	 	 
	 

	 	 
	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	Date:	 	 
	 

	 	 	 	 	 	 

Attachments: Restricted Stock Unit Agreement, 2005 Equity Incentive Plan

 

 

Attachment I

Restricted Stock Unit Agreement

 

 

Attachment II

2005 Equity Incentive Plan

 

 

SGX Pharmaceuticals, Inc.

2005 Equity Incentive Plan

Restricted Stock Unit Agreement — Executive

     Pursuant
to your Restricted Stock Unit Grant Notice (“Grant
Notice”) and this Restricted
Stock Unit Agreement (this “Agreement”), SGX
Pharmaceuticals, Inc. (the “Company”) has awarded you
a Restricted Stock Unit under Section 7(c) of the SGX Pharmaceuticals, Inc. 2005 Equity Incentive
Plan (the “Plan”) for the number of shares of the Company’s common stock (the “Common Stock”)
indicated in the Grant Notice (collectively, the
“Award”). Defined terms not explicitly defined
in this Agreement but defined in the Plan shall have the same definitions as in the Plan.

     The details of your Award are as follows.

     1. Distribution of Shares of Common Stock. The Company will deliver to you
a number of shares of Common Stock equal to the number of vested shares of Common Stock subject to
your Award on the vesting date or dates provided in your Grant Notice; provided, however, that to
the extent a vesting date occurs no sooner than 12 months following the Date of Grant specified in
your Grant Notice and if, within the 30-day period following the Date of Grant indicated on your
Grant Notice, you elect to defer delivery of such shares of Common Stock beyond the vesting date,
then the Company will deliver such shares to you on the date or dates that you so elect (the
“Settlement Date”); provided further, that notwithstanding any such deferral election, upon
termination of your Continuous Service, all vested shares of Common Stock subject to your Award
shall be delivered to you as soon as practicable after your date of termination. If such deferral
election is made, the Board (or appropriate committee thereof) will, in its sole discretion,
establish the rules and procedures for such deferrals. Notwithstanding the foregoing, in the
event that the Company determines that you are subject to its policy regarding insider trading of
the Company’s stock and any shares of Common Stock subject to your Award are scheduled to be
delivered on a day (the “Original Distribution
Date”) that does not occur during an open “window
period” applicable to you, as determined by the Company in accordance with such policy, then such
shares shall not be delivered on such Original Distribution Date and shall instead be delivered as
soon as practicable within the next open “window period” applicable to you pursuant to such
policy.

     2. Consideration. The Common Stock delivered to you pursuant to Section 1
of this Agreement shall be deemed paid, in whole or in part, in consideration of your services to
the Company in the amounts and to the extent required by law.

     3. Vesting. Subject to the limitations contained herein, your Award will
vest as provided in the Grant Notice, provided that vesting will cease upon the termination of
your Continuous Service. Notwithstanding the foregoing, if you elect to defer receipt of the
shares pursuant to Section 1 of this Agreement, then any shares subject to this Award that would
otherwise vest prior to the date that is 12 months following the date of such election shall
instead vest on the date that is 12 months following the date of your election to defer.

 

 

     4. Number of Shares. The number of shares of Common Stock subject to your
Award referenced in your Grant Notice may be adjusted from time to time for Capitalization
Adjustments as set forth in the Plan.

     5. Conditions to Issuance and Delivery of Shares. Notwithstanding any other
provision of this Agreement or the Plan, the Company will not be obligated to issue or deliver any
shares of Common Stock pursuant to this Agreement (i) until all conditions to the Award have been
satisfied or removed, (ii) until, in the opinion of counsel to the Company, all applicable federal
and state laws and regulations have been complied with, (iii) if the outstanding Common Stock is
at the time listed on any stock exchange or included for quotation on an inter-dealer system,
until the shares to be delivered have been listed or included or authorized to be listed or
included on such exchange or system upon official notice of notice of issuance, (iv) if it might
cause the Company to issue or sell more shares of Common Stock than the Company is then legally
entitled to issue or sell, and (v) until all other legal matters in connection with the issuance
and delivery of such shares have been approved by counsel to the Company.

     6. Execution of Documents. You hereby acknowledge and agree that the
manner selected by the Company by which you indicate your consent to your Grant Notice is also
deemed to be your execution of your Grant Notice and of this Agreement. You further agree that
such manner of indicating consent may be relied upon as your signature for establishing your
execution of any documents to be executed in the future in connection with your Award. This
Agreement shall be deemed to be signed by the Company and you upon the respective signing by the
Company and you of the Grant Notice to which it is attached.

     7. Non-transferability. Your Award is not transferable, except by will or
by the laws of descent and distribution. Notwithstanding the foregoing, by delivering written
notice to the Company, in a form satisfactory to the Company, you may designate a third party who,
in the event of your death, will thereafter be entitled to receive any distribution of shares
pursuant to Section 1 of this Agreement.

     8. Award Not a Service Contract. Your Award is not an employment or
service contract, and nothing in your Award will be deemed to create in any way whatsoever any
obligation on your part to continue in the employ of the Company or an Affiliate, or on the part
of the Company or an Affiliate to continue your employment. In addition, nothing in your Award
will obligate the Company or an Affiliate, their respective stockholders, boards of Directors or
Employees to continue any relationship that you might have as a Director or Consultant for the
Company or an Affiliate.

     9. Unsecured Obligation. Your Award is unfunded, and as a holder of a
vested Award, you will be considered an unsecured creditor of the Company with respect to the
Company’s obligation, if any, to issue shares of Common Stock pursuant to this Agreement. You
will not have voting or any other rights as a stockholder of the Company with respect to the
shares of Common Stock issued pursuant to this Agreement until such shares are issued to you
pursuant to Section 1 of this Agreement. Upon such issuance, you will obtain full voting and
other rights as a stockholder of the Company. Nothing contained in this Agreement, and no action
taken pursuant to its provisions, will create or be construed to create

2.

 

a trust of any kind or a fiduciary relationship between you and the Company or any other
person.

     10. Withholding Obligations.

          (a) On or before the time you receive a distribution of shares pursuant to your Award, or at
any time thereafter as requested by the Company, you hereby authorize withholding from, at the
Company’s election, vested shares of Common Stock distributable to you, payroll and any other
amounts payable to you and otherwise agree to make adequate provision for, as determined by the
Company, any sums required to satisfy the federal, state, local and foreign tax withholding
obligations of the Company or an Affiliate, if any, which arise in connection with your Award.

          (b) Unless the tax withholding obligations of the Company or any Affiliate are satisfied, the
Company will have no obligation to issue a certificate for such shares of Common Stock in
connection with your Award.

     11. Notices. All notices with respect to the Plan shall be in writing and
shall be hand delivered or sent by first class mail or reputable overnight delivery service,
expenses prepaid. Notice may also be given by electronic mail or facsimile and shall be effective
on the date transmitted if confirmed within 24 hours thereafter by a signed original sent in a
manner provided in the preceding sentence. Notices to the Company or the Board shall be delivered
or sent to the Company’s headquarters, to the attention of its Chief Financial Officer. Notices
to any Participant or holder of shares of Common Stock issued pursuant to an Award shall be
sufficient if delivered or sent to such person’s address as it appears in the regular records of
the Company or its transfer agent.

     12. Headings. The headings of the Sections in this Agreement are inserted
for convenience only and will not be deemed to constitute a part of this Agreement or to affect
the meaning of this Agreement.

     13. Amendment. This Agreement may be amended only by a writing executed by
the Company and you which specifically states that it is amending this Agreement. Notwithstanding
the foregoing, this Agreement may be amended solely by the Board (or appropriate committee
thereof) by a writing which specifically states that it is amending this Agreement, so long as a
copy of such amendment is delivered to you, and provided that no such amendment adversely
affecting your rights hereunder may be made without your written consent. Without limiting the
foregoing, the Board (or appropriate committee thereof) reserves the right to change, by written
notice to you, the provisions of this Agreement in any way it may deem necessary or advisable to
carry out the purpose of the grant as a result of any change in applicable laws or regulations or
any future law, regulation, ruling, or judicial decision, provided that any such change will be
applicable only to rights relating to that portion of the Award which is then subject to
restrictions as provided herein.

     14. Miscellaneous.

          (a) The rights and obligations of the Company under your Award will be transferable by the
Company to any one or more persons or entities, and all covenants and

3.

 

agreements hereunder will inure to the benefit of, and be enforceable by the Company’s
successors and assigns. Your rights and obligations under your Award may not be assigned by you,
except with the prior written consent of the Company.

          (b) You agree upon request to execute any further documents or instruments necessary or
desirable in the sole determination of the Company to carry out the purposes or intent of your
Award.

     15. Governing Plan Document. Your Award is subject to all the provisions
of the Plan, the provisions of which are hereby made a part of your Award, and is further subject
to all interpretations, amendments, rules and regulations which may from time to time be
promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions
of your Award and those of the Plan, the provisions of the Plan will control; provided, however,
that Section 1 of this Agreement will govern the timing of any distribution of Shares under your
Award. The Board (or appropriate committee thereof) will have the power to interpret the Plan and
this Agreement and to adopt such rules for the administration, interpretation, and application of
the Plan as are consistent therewith and to interpret or revoke any such rules. All actions taken
and all interpretations and determinations made by the Board (or appropriate committee thereof)
will be final and binding upon you, the Company, and all other interested persons. No member of
the Board (or appropriate committee thereof) will be personally liable for any action,
determination, or interpretation made in good faith with respect to the Plan or this Agreement.

     16. Effect on Other Employee Benefit Plans. The value of the Award subject
to this Agreement will not be included as compensation, earnings, salaries, or other similar terms
used when calculating the Employee’s benefits under any employee benefit plan sponsored by the
Company or any subsidiary except as such plan otherwise expressly provides. The Company expressly
reserves its rights to amend, modify, or terminate any of the Company’s or any subsidiary’s
employee benefit plans.

     17. Choice of Law. The interpretation, performance and enforcement of this
Agreement will be governed by the law of the state of California without regard to such state’s
conflicts of laws rules.

     18. Severability. If all or any part of this Agreement or the Plan is
declared by any court or governmental authority to be unlawful or invalid, such unlawfulness or
invalidity will not invalidate any portion of this Agreement or the Plan not declared to be
unlawful or invalid. Any Section of this Agreement (or part of such a Section) so declared to be
unlawful or invalid will, if possible, be construed in a manner which will give effect to the
terms of such Section or part of a Section to the fullest extent possible while remaining lawful
and valid.

4.exv10w42

 

EXHIBIT 10.42

Execution Version

NOVARTIS PHARMA AG

AND

SGX PHARMACEUTICALS, INC.

STOCK PURCHASE AGREEMENT

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Page
	1.	 	Purchase and Sale of Common Stock	 	 	1	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	1.1	 	 	Sale of the Common Stock
	 	 	1	 
	 
	 	 	 	 	 	 	 	 	 	 
	2.	 	Closing Date; Deliveries	 	 	1	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	2.1	 	 	Closing Date
	 	 	1	 
	 

	 	 	2.2	 	 	Deliveries
	 	 	1	 
	 

	 	 	2.3	 	 	Further Assurances
	 	 	1	 
	 
	 	 	 	 	 	 	 	 	 	 
	3.	 	Representations and Warranties of the Company	 	 	2	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	3.1	 	 	Organization, Good Standing and Qualification
	 	 	2	 
	 

	 	 	3.2	 	 	Capitalization and Voting Rights
	 	 	2	 
	 

	 	 	3.3	 	 	Subsidiaries
	 	 	3	 
	 

	 	 	3.4	 	 	Authorization
	 	 	3	 
	 

	 	 	3.5	 	 	No Conflict
	 	 	3	 
	 

	 	 	3.6	 	 	Valid Issuance of Common Stock
	 	 	4	 
	 

	 	 	3.7	 	 	Liabilities
	 	 	4	 
	 

	 	 	3.8	 	 	Governmental Consents
	 	 	4	 
	 

	 	 	3.9	 	 	Litigation
	 	 	4	 
	 

	 	 	3.10	 	 	Employees and Consultants
	 	 	5	 
	 

	 	 	3.11	 	 	Proprietary Rights.
	 	 	5	 
	 

	 	 	3.12	 	 	Agreements; Action
	 	 	6	 
	 

	 	 	3.13	 	 	Registration Rights
	 	 	7	 
	 

	 	 	3.14	 	 	Title to Property and Assets
	 	 	7	 
	 

	 	 	3.15	 	 	Financial Statements and SEC Filings
	 	 	7	 
	 

	 	 	3.16	 	 	Disclosure Controls and Procedures
	 	 	8	 
	 

	 	 	3.17	 	 	Accounting Controls
	 	 	8	 
	 

	 	 	3.18	 	 	Employee Benefit Plans
	 	 	8	 
	 

	 	 	3.19	 	 	Tax Returns, Payments and Elections
	 	 	8	 
	 

	 	 	3.20	 	 	Insurance
	 	 	9	 
	 

	 	 	3.21	 	 	Labor Agreements and Actions
	 	 	9	 
	 

	 	 	3.22	 	 	Real Property Holding Corporation
	 	 	9	 
	 

	 	

	3.23

3.24	

	 	Investment Company

Offering
	 	 	9

9	 
	 

	 	 	3.25	 	 	Environmental Matters
	 	 	10	 
	 

	 	 	3.26	 	 	Securities Laws
	 	 	10	 
	 

	 	 	3.27	 	 	Licenses and Other Rights; Compliance with Laws
	 	 	11	 
	 

	 	 	3.28	 	 	Broker or Finders
	 	 	11	 
	 

	 	 	3.29	 	 	Market Listing
	 	 	11	 
	 

	 	 	3.30	 	 	Related Party Transactions
	 	 	11	 

i

 

	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Page
	 

	 	 	3.31	 	 	No Material Adverse Effect
	 	 	11	 
	 
	 	 	 	 	 	 	 	 	 	 
	4.	 	Representations and Warranties of the Investor	 	 	11	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	4.1	 	 	Authorization, Governmental Consents and Compliance with Other Instruments
	 	 	11	 
	 

	 	 	4.2	 	 	Purchase Entirely for Own Account
	 	 	12	 
	 

	 	 	4.3	 	 	Disclosure of Information
	 	 	12	 
	 

	 	 	4.4	 	 	Investment Experience and Accredited Investor Status
	 	 	12	 
	 

	 	 	4.5	 	 	No Governmental Review
	 	 	12	 
	 

	 	 	4.6	 	 	Residency
	 	 	12	 
	 

	 	 	4.7	 	 	Foreign Investors
	 	 	12	 
	 

	 	 	4.8	 	 	No Short Sales
	 	 	13	 
	 

	 	 	4.9	 	 	Restricted Securities
	 	 	13	 
	 

	 	 	4.10	 	 	Legends
	 	 	13	 
	 
	 	 	 	 	 	 	 	 	 	 
	5.	 	Conditions to Closing of Investor	 	 	13	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	5.1	 	 	Representations and Warranties Correct
	 	 	14	 
	 

	 	 	5.2	 	 	Covenants
	 	 	14	 
	 

	 	 	5.3	 	 	Compliance Certificate
	 	 	14	 
	 

	 	 	5.4	 	 	Certification of Resolutions and Officers
	 	 	14	 
	 

	 	 	5.5	 	 	Organizational Documents
	 	 	14	 
	 

	 	 	5.6	 	 	Good Standing Certificate
	 	 	14	 
	 

	 	 	5.7	 	 	Cross Receipt
	 	 	14	 
	 

	 	 	5.8	 	 	Other Agreements
	 	 	15	 
	 

	 	 	5.9	 	 	Proceedings and Documents
	 	 	15	 
	 

	 	 	5.10	 	 	Continued Market Listing
	 	 	15	 
	 

	 	 	5.11	 	 	Registration Rights Consent
	 	 	15	 
	 
	 	 	 	 	 	 	 	 	 	 
	6.	 	Conditions to Closing of the Company	 	 	15	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	6.1	 	 	Representations and Warranties Correct
	 	 	15	 
	 

	 	 	6.2	 	 	Cross Receipt
	 	 	15	 
	 

	 	 	6.3	 	 	Other Agreements
	 	 	15	 
	 

	 	 	6.4	 	 	Lock-Up Agreement
	 	 	15	 
	 
	 	 	 	 	 	 	 	 	 	 
	7.	 	Mutual Conditions to Closing	 	 	15	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	7.1	 	 	Qualifications
	 	 	16	 
	 

	 	 	7.2	 	 	Absence of Litigation
	 	 	16	 
	 
	 	 	 	 	 	 	 	 	 	 
	8.	 	Additional Covenants and Agreements	 	 	16	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	8.1	 	 	Share Legend Removal
	 	 	16	 
	 

	 	 	8.2	 	 	Use of Proceeds
	 	 	16	 
	 

	 	 	8.3	 	 	Standstill Agreement
	 	 	16	 
	 

	 	 	8.4	 	 	Termination of Standstill
	 	 	17	 

ii

 

	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Page
	 

	 	 	8.5	 	 	Share Ownership
	 	 	18	 
	 
	 	 	 	 	 	 	 	 	 	 
	9.	 	Miscellaneous	 	 	18	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	9.1	 	 	Termination
	 	 	18	 
	 

	 	 	9.2	 	 	Effect of Termination
	 	 	18	 
	 

	 	 	9.3	 	 	Survival of Warranties
	 	 	18	 
	 

	 	 	9.4	 	 	Attorney’s Fees
	 	 	19	 
	 

	 	 	9.5	 	 	Remedies
	 	 	19	 
	 

	 	 	9.6	 	 	Successors and Assigns
	 	 	19	 
	 

	 	 	9.7	 	 	Entire Agreement
	 	 	19	 
	 

	 	 	9.8	 	 	Governing Law and Consent to Jurisdiction
	 	 	19	 
	 

	 	 	9.9	 	 	Counterparts
	 	 	19	 
	 

	 	 	9.10	 	 	Titles and Subtitles
	 	 	20	 
	 

	 	 	9.11	 	 	Nouns and Pronouns
	 	 	20	 
	 

	 	 	9.12	 	 	Notices
	 	 	20	 
	 

	 	 	9.13	 	 	Finder’s Fee
	 	 	21	 
	 

	 	 	9.14	 	 	Expenses
	 	 	21	 
	 

	 	 	9.15	 	 	Amendments and Waivers
	 	 	21	 
	 

	 	 	9.16	 	 	Severability
	 	 	21	 
	 

	 	 	9.17	 	 	Confidentiality and Publicity
	 	 	21	 
	 

	 	 	9.18	 	 	Definitions
	 	 	22	 
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	Annex A — Disclosure Schedule	 	 	 	 
	 	 	Exhibit A — Cross Receipt	 	 	 	 
	 	 	Exhibit B — Investor Rights Agreement Amendment	 	 	 	 
	 	 	Exhibit C — Lock-Up Agreement	 	 	 	 

iii

 

STOCK PURCHASE AGREEMENT

     THIS STOCK PURCHASE AGREEMENT (this “Agreement”) is made as of the 27th day
of March, 2006, by and between Novartis Pharma AG (“Novartis” or the “Investor”), a
corporation organized under the laws of Switzerland, with its principal place of business at
Lichtstrasse 35, CH-4002, Basel, Switzerland, and SGX Pharmaceuticals, Inc., (the
“Company”), a Delaware corporation with its principal place of business at 10505 Roselle
Street, San Diego, California 92121.

     THE PARTIES HEREBY AGREE AS FOLLOWS:

1. Purchase and Sale of Common Stock.

     1.1 Sale of the Common Stock.

          (a) Subject to the terms and conditions of this Agreement, the Company shall issue and sell to
the Investor and the Investor shall purchase from the Company that number of shares of common stock
(the “Shares”), par value $0.001 per share of the Company (the “Common Stock”)
equal to the quotient obtained by dividing (i) Five Million U.S. Dollars (US$5,000,000) (the
“Purchase Price”) by (ii) the Share Price determined in accordance with Section 1.1(b)
below.

          (b) The “Share Price” means $7.84.

2. Closing Date; Deliveries.

     2.1 Closing Date. Subject to the terms and conditions of this Agreement, the closing of the
purchase and sale of the Shares (the “Closing”) shall be held on or prior to the second
(2nd) business day after the satisfaction or waiver of all of the conditions to the
Closing (other than those conditions that by their nature are to be satisfied or waived at the
Closing) or such other date upon which the Company and the Investor may agree. The date of the
Closing is hereinafter referred to as the “Closing Date.”

     2.2 Deliveries.

          (a) Deliveries by the Company. At the Closing, the Company shall deliver to the
Investor a stock certificate, registered in the Investor’s name, representing the Shares purchased
by the Investor. The Company will also make all such deliveries as are contemplated by Section 5
of this Agreement prior to or in connection with the Closing.

          (b) Deliveries by the Investor. At the Closing, the Investor shall deliver the
Purchase Price by wire transfer of same day funds per the Company’s wiring instructions (which
shall have been delivered to the Investor not less than two business days before the Closing Date).
The Investor will also make all such deliveries as are contemplated by Section 6 of this Agreement
prior to or in connection with the Closing.

     2.3 Further Assurances. The Company and the Investor hereby covenant and agree without the
necessity of any further consideration, to execute, acknowledge and deliver any and

 

 

all such other documents and take any such other action as may be reasonably necessary to carry out
the intent and purposes of this Agreement.

3. Representations and Warranties of the Company. The Company hereby represents and warrants to
the Investor that, except as set forth in the corresponding section of the Disclosure Schedule
delivered to Investor concurrently with the execution hereof (the “Disclosure Schedule”) or
in another section of the Disclosure Schedule, but only to the extent the relevance to any other
Section is reasonably apparent from the actual text of such disclosure, or as otherwise set forth
in the Company’s Amendment No. 8 to Registration Statement on Form S-1 filed with the SEC on
January 31, 2006 (the “Registration Statement”) or any Annual Report on Form 10-K or
Current Report on Form 8-K filed by the Company with the SEC at least two (2) business days prior
to the date hereof, the statements contained in this Section 3 are true and correct as of the date
hereof:

     3.1 Organization, Good Standing and Qualification. The Company is a corporation duly organized,
validly existing and in good standing under the laws of the State of Delaware. The Company has all
requisite corporate power and corporate authority to own and operate its properties and assets, to
carry on its business as now conducted and as currently proposed to be conducted, to enter into
this Agreement, to sell the Shares in accordance with the terms hereof and to perform its
obligations hereunder. The Company, and each of its Subsidiaries, is qualified to transact
business and is in good standing in each jurisdiction in which the failure to qualify would
reasonably be expected to have, individually or in the aggregate, a material adverse effect on the
business, properties, financial condition or results of operations of the Company and its
Subsidiaries taken as a whole (a “Material Adverse Effect”). The Company has delivered to
the Investor true, correct and complete copies of the Company’s Amended and Restated Certificate of
Incorporation (the “Certificate of Incorporation”) and the Company’s Bylaws in effect on
the date hereof.

     3.2 Capitalization and Voting Rights.

          (a) The authorized capital of the Company as of the date of this Agreement consists of:

     (i) Preferred Stock. 5,000,000 shares of Preferred Stock, par value
$0.001 per share (the “Preferred Stock”), of which no shares are issued and
outstanding.

     (ii) Common Stock. 75,000,000 shares of Common Stock, of which
14,375,940 shares are issued and outstanding as of March 22, 2006.

          (b) There are (i) other than lock-up restrictions with the Company or the underwriters in the
Company’s initial public offering and the restrictions set forth in the Investor Rights Agreement,
no restrictions on the transfer of capital stock of the Company imposed by the Certificate of
Incorporation or Bylaws of the Company, or any agreement to which the Company is a party, any order
of any court or any governmental agency to which the Company is subject, or any statute other than
those imposed by relevant state and federal securities laws; and (ii) no cumulative voting rights
for any of the Company’s capital stock.

2

 

          (c) As of March 22, 2006, of the authorized Common Stock (i) 195,629 shares have been reserved
for issuance upon exercise of outstanding warrants, and (ii) 1,706,045 shares have been reserved
for issuance upon exercise of outstanding options or other stock-based awards under the 2000 Equity
Incentive Plan, 2005 Equity Incentive Plan, 2005 Non-Employee Directors’ Stock Option Plan and the
2005 Employee Stock Purchase Plan, and (iii) an aggregate of 866,009 shares remain available for
future issuance of options or other stock-based awards under the 2005 Equity Incentive Plan, the
2005 Non-Employee Directors’ Stock Option Plan and the 2005 Employee Stock Purchase Plan. Other
than as set forth in the preceding sentence, there are no other shares of Common Stock reserved for
issuance. There are no outstanding options, warrants, or agreements pursuant to which the Company
is or may become obligated to issue or sell any shares of its capital stock or any other securities
of the Company in respect of which a sufficient number of such shares or securities have not been
reserved for issuance upon exercise or conversion thereof.

     3.3 Subsidiaries. All the outstanding shares of capital stock of each Subsidiary are validly
issued, fully paid and nonassessable, and are owned by the Company free and clear of any
Encumbrances. There are no options, warrants, convertible securities, or other rights, agreements,
arrangements or commitments of any character relating to the capital stock of any Subsidiary.
There are no voting trusts, stockholder agreements, proxies or other agreements or understandings
in effect with respect to the voting or transfer of any shares of capital stock of or any other
interests in any Subsidiary.

     3.4 Authorization. All corporate action on the part of the Company, its officers, directors and
its stockholders necessary for the authorization, execution and delivery of this Agreement and the
Investor Rights Agreement Amendment, the performance of all obligations of the Company hereunder
and under the Investor Rights Agreement and the authorization, issuance and delivery of the Shares
to be sold hereunder, has been taken. This Agreement and the Investor Rights Agreement Amendment
have been duly executed and delivered by the Company and this Agreement and the Investor Rights
Agreement constitute valid and legally binding obligations of the Company, enforceable against the
Company in accordance with their terms (except as such enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or other laws of general application relating to
or affecting enforcement of creditors rights, or by equitable principles and except as rights to
indemnity and contribution may be limited by state or federal securities laws or public policy
underlying such laws).

     3.5 No Conflict. The execution and delivery of this Agreement and the Investor Rights Agreement
Amendment, the performance of this Agreement and the Investor Rights Agreement and compliance with
the provisions hereof and thereof by the Company, will not:

          (a) violate any provision of law, statute, ordinance, rule or regulation or any ruling, writ,
injunction, order, judgment or decree of any court, administrative agency or other Governmental
Authority (as used herein, “Governmental Authority” shall mean any nation or government,
any federal, state, municipal, local, provincial, regional or other political subdivision thereof,
and any Person exercising executive, legislative, judicial regulatory or administrative functions
of or pertaining to government), the violation of which would reasonably be expected to have,
individually or in the aggregate, a Material Adverse Effect;

3

 

          (b) conflict with or result in any breach of any of the terms, conditions or provisions of, or
constitute (with due notice or lapse of time, or both) a default (or give rise to any right of
termination, cancellation or acceleration) under (i) any material agreement, document, instrument,
contract, understanding, arrangement, note, indenture, mortgage or lease to which the Company is a
party or under which the Company or any of its assets is bound or affected, other than conflicts or
breaches which would not have, individually or in the aggregate, a Material Adverse Effect, (ii)
the Company’s Certificate of Incorporation, or (iii) the Bylaws of the Company; or

          (c) result in the creation of any Encumbrance upon any of the Shares or on any of the
properties or assets of the Company or any Subsidiary, other than Encumbrances on any properties or
assets which would not have, individually or in the aggregate, a Material Adverse Effect.

     3.6 Valid Issuance of Common Stock. When issued, sold and delivered in accordance with the terms
hereof for the consideration expressed herein, the Shares will be duly authorized, validly issued,
fully paid and nonassessable, and, other than as set forth or contemplated herein or in the
Investor Rights Agreement, will not be subject to any preemptive rights, rights of first refusal or
other similar rights.

     3.7 Liabilities. Since September 30, 2005, the Company has not incurred any unpaid indebtedness
for money borrowed or any other contractual liabilities of the type required to be disclosed on a
balance sheet prepared in accordance with United States generally accepted accounting principles
(“GAAP”), in excess of $200,000 in any instance, or $500,000 in the aggregate, other than
liabilities incurred in the ordinary course of business.

     3.8 Governmental Consents. No consent, approval, order or authorization of, or registration,
qualification, designation, declaration, notification or filing with, any federal, state or local
Governmental Authority, the National Association of Securities Dealers or such other
self-regulatory organization or stock exchange on which the Common Stock is listed, on the part of
the Company is required in connection with the valid execution, delivery and performance of this
Agreement or the valid execution and delivery of the Investor Rights Agreement Amendment, the
offer, sale, or issuance of the Shares or the consummation of any other transaction contemplated
hereby, except the filing required to be made under federal securities laws and the qualification
(or the taking of such action as may be necessary to secure an exemption from qualification) of the
offer and sale of the Shares under applicable Blue Sky laws, which filings and qualifications, if
required to be made prior to the Closing, shall be accomplished prior to the Closing.

     3.9 Litigation. There is no action, suit, proceeding or investigation pending or, to the Company’s
knowledge, currently threatened against the Company or any Subsidiary which questions the validity
of this Agreement or the Investor Rights Agreement or the right of the Company to enter into such
agreements, or to consummate the transactions contemplated hereby or thereby, or which would
reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect, or
result in any material change in the current equity ownership of the Company. To the Company’s
knowledge, there are no legal actions pending or threatened in writing involving the violation by
any current or former employee of the Company of any

4

 

employment contract or proprietary information agreement with any prior employer of such employee
relating to their employment with the Company or any Proprietary Rights used by the Company. To
the Company’s knowledge, there has not been, nor is there pending or contemplated, any
investigation by the SEC involving the Company or any current or former director or officer of the
Company relating to such officer’s or director’s activities with the Company. The Company has not
received any stop order or other order suspending the effectiveness of the Registration Statement
and, to the Company’s knowledge, the SEC has not issued any such order. The Company is not a party
to any order, writ, injunction, judgment or decree of any court. There is no action, suit,
proceeding or investigation initiated by the Company currently pending.

     3.10 Employees and Consultants.

          (a) Each employee of, or consultant to, the Company or its Subsidiaries, who has access to
confidential or proprietary information of the Company or its Subsidiaries, is a signatory to, and,
to the Company’s knowledge, is bound by, an agreement with the Company relating to nondisclosure,
proprietary information and assignment of patent, copyright and other intellectual property rights.

          (b) To the Company’s knowledge, no employee of, or consultant to, the Company or its
Subsidiaries is in violation of any term of any employment contract, patent disclosure agreement or
any other contract or agreement with the Company or any Subsidiary including, but not limited to,
those matters relating to (i) the relationship of any such employee with the Company or any
Subsidiary, or (ii) unfair competition, trade secrets or proprietary information.

     3.11 Proprietary Rights.

          (a) Except as set forth in Section 3.11(a) of the Disclosure Schedule, to the knowledge of the
Company, the Company owns or possesses, or believes it can obtain, rights to use all U.S. and
non-U.S. patents, trade secrets, know-how, trademarks, service marks copyrights, and other
proprietary and intellectual property rights (collectively, the “Proprietary Rights”)
necessary for the conduct of the Company’s and its Subsidiaries’ business as now conducted (such
Propriety Rights owned by or licensed to the Company or its Subsidiaries collectively, the
“Company Rights”). To the knowledge of the Company, (i) the Company’s rights in the
Company Rights are valid and enforceable; (ii) except to the extent not yet due, all necessary and
material registration, maintenance and renewal fees in respect of the Company Rights in existence
as of the date hereof have been paid; (iii) none of the Company or its Subsidiaries have infringed
or are infringing the issued patents of any Person in existence as of the date hereof, and have not
received any written notice and are not subject to any actual or threatened (in writing)
proceedings alleging such, that would reasonably be expected to have a Material Adverse Effect;
(iv) no Person is infringing or otherwise violating any Company Rights; and (v) there are no
material breaches or defaults of, or any disputes or threatened disputes concerning, any of the
Material IP Contracts.

          (b) Schedule 3.11(b) contains a complete and accurate list of all material agreements required
to be filed by the Company pursuant to Item 601 of Regulation S-K that

5

 

have not been so filed by the Company prior to the date hereof granting any rights (including,
without limitation, licenses, options and covenants not to sue) with respect to any of the Company
Rights (collectively, the “Material IP Contracts”), specifically indicating, as applicable,
each amendment thereto.

     3.12 Agreements; Action.

          (a) There are no agreements, understandings, transactions or proposed transactions between the
Company or any Subsidiary and any of its officers, directors, or affiliates of a nature required to
be disclosed pursuant to the provisions of Item 404 of Regulation S-K, and none of any such
individuals or entities has any material interest in any such agreement, understanding, transaction
or proposed transaction of a nature required to be disclosed pursuant to the provisions of Item 404
of Regulation S-K.

          (b) Neither the Company nor any Subsidiary thereof has (i) declared or paid any dividends, or
authorized or made any distribution upon or with respect to any class or series of its capital
stock (other than a dividend or distribution by a wholly-owned Subsidiary to the Company or to
another wholly-owned Subsidiary of the Company), (ii) since September 30, 2005, made any loans or
advances to any Person in excess of $200,000 in any one instance and $500,000 in the aggregate,
other than ordinary advances to employees for travel expenses or in the ordinary course of
business, or (iii) since September 30, 2005, sold, exchanged or otherwise disposed of any of its
assets or rights that would have been required to be disclosed by the Company in a Current Report
on Form 8-K.

          (c) Neither the Company nor any Subsidiary thereof has admitted in writing its inability to
pay its debts generally as they become due, filed or consented to the filing against it of a
petition in bankruptcy or a petition to take advantage of any insolvency act, made an assignment
for the benefit of creditors, consented to the appointment of a receiver for itself or for the
whole or any substantial part of its property, or had a petition in bankruptcy filed against it,
been adjudicated as bankrupt, or filed a petition or answer seeking reorganization or arrangement
under the federal bankruptcy laws or any other laws of the United States or any other jurisdiction.

          (d) Each of the Company and its Subsidiaries is in compliance with all obligations, agreements
and conditions contained in any evidence of indebtedness or any loan agreement or other contract or
agreement (whether or not relating to indebtedness) to which the Company or such Subsidiary is a
party or is subject (collectively, the “Obligations”), the lack of compliance with which
could afford any Person the right to (i) accelerate any indebtedness or (ii) terminate any right or
agreement of the Company or such Subsidiary, the acceleration or termination of which would
reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect. To
the Company’s knowledge, all other parties to such Obligations are in compliance with the terms and
conditions of such Obligations, except where such failure to be in compliance would not reasonably
be expected to have, individually or in the aggregate, a Material Adverse Effect.

          (e) There are no agreements, understandings, instruments, contracts or proposed transactions
to which the Company or any Subsidiary is a party or by which it is bound

6

 

that are required to be filed by the Company as material exhibits pursuant to Item 601 of
Regulation S-K that have not been so filed and may involve (i) obligations (contingent or
otherwise) of, or payments to, the Company or such Subsidiary in excess of $500,000, other than
obligations of, or payments to, the Company or a Subsidiary arising from purchase or sale
agreements entered into in the ordinary course of business or (ii) the license of any patent,
copyright, trade secret or other proprietary right to or from the Company or a Subsidiary, other
than licenses arising from the purchase of “off the shelf” or other standard products.

     3.13 Registration Rights. Other than pursuant to the Investor Rights Agreement, the Company does
not have any obligation to provide registration rights with respect to shares of the Company’s
capital stock under the Securities Act of 1933, as amended (the “Securities Act”),
including piggyback rights, to any Person.

     3.14 Title to Property and Assets. The Company has good title to, or has valid rights to lease or
otherwise use, all of the property and assets reflected on its balance sheet as of September 30,
2005, except those assets sold, consumed or otherwise disposed of since the date of such balance
sheet in the ordinary course of business, none of which assets sold, consumed or otherwise disposed
of since the date of such balance sheet, either alone or in the aggregate are material, either in
nature or amount, to the business of the Company and its Subsidiaries. With respect to the
property and assets they lease, each of the Company and its Subsidiaries is in all respects in
compliance with such leases, has not received written notice of any allegations that it is in
default thereunder in any respect and holds a valid leasehold interest in such property and assets
free of any Encumbrances, except where such failure to be in compliance, or such default or
Encumbrance would not reasonably be expected to have a Material Adverse Effect.

     3.15 Financial Statements and SEC Filings.

          (a) The Company has (i) made available to the Investor the Registration Statement containing
its audited financial statements at and for the fiscal year ended December 31, 2004 (the
“Audited Financial Statements”) and its unaudited financial statements at and for the
nine-month period ended September 30, 2005 (the “Interim Financial Statements”) and (ii)
delivered to the Investor its unaudited financial statements at and for the fiscal year ended
December 31, 2005 (the “2005 Unaudited Financial Statements” and together with the Audited
Financial Statements and the Interim Financial Statements, collectively, the “Financial
Statements”), and with respect to the Audited Financial Statements, the notes thereto. The
Financial Statements have been prepared in accordance with GAAP applied on a consistent basis
throughout the periods indicated and fairly present the financial condition and operating results
of the Company as of the dates, and for the periods, indicated therein, except as may be otherwise
indicated in the Financial Statements or notes thereto or, in the case of the Interim Financial
Statements or the 2005 Unaudited Financial Statements, to the extent they may not include
footnotes, do not reflect year-end adjustments or may conform to the SEC’s rules and instructions
for disclosure with respect to interim periods. The Company’s audited financial statements at and
for the end of the year ended December 31, 2005, as they will be filed in the Company’s Annual
Report on Form 10-K, will not differ in the aggregate in any material respect in any manner adverse
to the Company from the 2005 Unaudited Financial Statements, except for the completion of
footnotes. The Company maintains and consistently applies and will

7

 

continue to maintain and consistently apply a standard system of accounting established and
administered in accordance with GAAP.

          (b) Since January 31, 2006, the Company has filed with the SEC all reports, schedules, forms,
statements and other documents, including the Registration Statement and the prospectus contained
therein (including exhibits and all other information incorporated therein) required by federal
securities laws to be filed with the SEC (“Company SEC Documents”). As of their respective
dates, the Company SEC Documents complied in all material respects with the requirements of the
Securities Act or the Securities Exchange Act, as the case may be, and the rules and regulations of
the SEC applicable to such Company SEC Documents, and no Company SEC Documents when filed contained
any untrue statement of a material fact or omitted to state a material fact required to be stated
therein or necessary in order to make the statements therein, in light of the circumstances under
which they were made, not misleading.

     3.16 Disclosure Controls and Procedures. The Company has established and maintains disclosure
controls and procedures (as defined in Securities Exchange Act Rules 13a-15(e) and 15d-15(e)) that
are effective in all material respects to ensure that material information relating to the Company,
including any consolidated Subsidiaries, is made known to its chief executive officer and chief
financial officer by others within those entities.

     3.17 Accounting Controls. The Company maintains a system of accounting controls sufficient to
provide reasonable assurances that (i) transactions are executed in accordance with management’s
general or specific authorization, (ii) transactions are recorded as necessary to permit
preparation of financial statements in conformity with GAAP and to maintain accountability for
assets, (iii) access to assets is permitted only in accordance with management’s general or
specific authorization, and (iv) the recorded accountability for assets is compared with existing
assets at reasonable intervals and appropriate action is taken with respect to any differences.

     3.18 Employee Benefit Plans. There are no “employee benefit plans” as such term is defined in
Section 3(3) of the Employee Retirement Income Security Act of 1974 (“ERISA”) maintained by
the Company or any Subsidiary or any stock purchase plan, stock option plan, fringe benefit plan,
bonus plan or any other deferred compensation agreement, plan, practice or pending arrangement
sponsored, maintained or to which contributions are made by the Company by or on behalf of current
or former employees of the Company or any Subsidiary, their dependents or any other party. The
Company has no current plans to substantially alter the benefits or coverage available under any of
the employee benefit, employee pension benefit or other plans, arrangements or practices referred
to above.

     3.19 Tax Returns, Payments and Elections . The Company and each of its Subsidiaries has filed all
tax returns and reports as required, and within the time prescribed by law (including, for this
purpose, any permitted extension), including without limitation, all federal, state and local
income, excise or franchise tax returns, real estate and personal property tax returns, sales and
use tax returns, payroll tax returns and other tax returns or reports required to be filed by it.
These returns and reports are true and correct in all material respects. The Company and each of
its Subsidiaries has paid or made provision for the payment of all accrued and unpaid taxes and
other charges to which the Company or any Subsidiary is subject and

8

 

which are not currently due and payable. The federal income tax returns of the Company have never
been audited, and none of the Company’s Subsidiaries are currently subject to any audit, by the
Internal Revenue Service, and neither the Company nor any Subsidiary has agreed to an extension of
the statute of limitations with respect to any of its tax years. Neither the Internal Revenue
Service nor any other taxing authority is now asserting, nor is threatening to assert, against the
Company or any Subsidiary any deficiency or claim for additional taxes or interest thereon or
penalties in connection therewith.

     3.20 Insurance. The Company has in full force and effect fire, casualty and liability insurance
policies, with coverage, in the case of property insurance, in such amount (subject to reasonable
deductibles) as the Company believes is necessary to allow it to replace any of its properties that
might be damaged or destroyed, and in the case of casualty and liability insurance, in such amounts
as the Company believes is customary and adequate for businesses similar to the business of the
Company, with the resources of the Company and at the stage of development of the Company.

     3.21 Labor Agreements and Actions. Neither the Company nor any of its Subsidiaries has any
collective bargaining agreements covering any of its employees, nor is the Company or any of its
Subsidiaries bound by or subject to (and none of its assets or properties is bound by or subject
to) any written or oral, express or implied, contract, commitment or arrangement with any labor
union, and no labor union has requested or, to the knowledge of the Company, has sought to
represent any of the employees, representatives or agents of the Company or any of its
Subsidiaries. There is no strike or other labor dispute involving the Company or any of its
Subsidiaries pending, or to the knowledge of the Company threatened, nor is the Company or any of
its Subsidiaries aware of any labor organization activity involving its employees. The Company is
not aware that any officer or key employee or that any group of key employees intends to terminate
their employment with the Company or any of its Subsidiaries, nor does the Company or any of its
Subsidiaries have a present intention to terminate the employment of any of the foregoing.

     3.22 Real Property Holding Corporation. The Company is not, and has not been at any time, a United
States real property holding corporation as defined in Section 897 of the Code.

     3.23 Investment Company. The Company is not and, after giving effect to the offering and sale of
the Shares, will not be an “investment company” as such term is defined in the Investment Company
Act of 1940, as amended (the “Investment Company Act”). The Company shall conduct its
business in a manner so that it will not become subject to the Investment Company Act.

     3.24 Offering. Subject to the accuracy of the Investor’s representations set forth in Section 4 of
this Agreement, the offer, sale and issuance of the Shares to be issued in conformity with the
terms of this Agreement constitute transactions which are: (i) in full compliance with all
applicable laws; and (ii) exempt from the registration requirements of the Securities Act and from
all applicable state registration or qualification requirements, other than those with which the
Company has complied or will comply with prior to the Closing or those that are permitted to be
complied with following the Closing.

9

 

     3.25 Environmental Matters.

          (a) To the Company’s knowledge, neither the Company nor any of its Subsidiaries is in material
violation of any Environmental Law (as hereinafter defined). As used in this Agreement,
“Environmental Law” shall mean any applicable federal, state and local law, ordinance, rule
or regulation that regulates, fixes liability for, or otherwise relates to, the handling, use
(including use in industrial processes, in construction, as building materials, or otherwise),
treatment, storage and disposal of hazardous and toxic wastes and substances, and to the discharge,
leakage, presence, migration, actual Release (as hereinafter defined) or threatened Release
(whether by disposal, a discharge into any water source or system or into the air, or otherwise) of
any pollutant or effluent.

          (b) To the Company’s knowledge, neither the Company nor any of its Subsidiaries has used,
generated, manufactured, refined, treated, transported, stored, handled, disposed, transferred,
produced, processed or released (hereinafter together defined as “Release”) any Hazardous
Materials (as hereinafter defined) on, from or affecting any Property (as hereinafter defined) in
any manner or by any means in material violation of any Environmental Laws and to the Company’s
knowledge after due investigation, there is no threat of such Release in material violation of
Environmental Laws. As used herein, the term “Property” shall include, without limitation,
land, buildings and laboratory facilities owned or leased by the Company or as to which the Company
now has any duties, responsibilities (for cleanup, remedy or otherwise) or liabilities under any
Environmental Laws, or as to which the Company or any Subsidiary of the Company may have such
duties, responsibilities or liabilities because of past acts or omissions of the Company or any
such Subsidiary or their predecessors, or because the Company or any such Subsidiary or their
predecessors in the past was such an owner or operator of, or bore some other relationship with,
such land, buildings or laboratory facilities. The term “Hazardous Materials” shall
include, without limitation, any flammable explosives, petroleum products, petroleum by-products,
radioactive materials, hazardous wastes, hazardous substances, toxic substances or related
materials as defined by Environmental Laws.

          (c) The Company has not received written notice that the Company or any of its Subsidiaries is
a party potentially responsible for costs incurred at a cleanup site or corrective action under any
Environmental Laws. The Company has not received any written requests for information in
connection with any inquiry by any Governmental Authority concerning disposal sites or with respect
to the violation of Environmental Laws.

          (d) The stockholders of the Company, other than those that are officers or employees of the
Company, have had no control over, or authority with respect to, the waste disposal operations of
the Company or any of its Subsidiaries.

     3.26 Securities Laws. Neither the Company nor anyone acting on its behalf has offered the Shares
for sale to, or solicited any offers to buy the Shares from any Person, in any case so as to
subject the Company, its promoter, directors or officers to any liability under the Securities Act,
the Securities Exchange Act of 1934, as amended (the “Securities Exchange Act”), or any
state securities or blue sky law (collectively, the “Securities Laws” ).

10

 

     3.27 Licenses and Other Rights; Compliance with Laws. Each of the Company and its Subsidiaries has
all franchises, permits, licenses and other rights and privileges necessary to permit it to own its
properties and to conduct its business as presently conducted and is in compliance thereunder,
except where the failure to have any such franchise, permit, license, right or privilege or such
non-compliance would not reasonably be expected to have a Material Adverse Effect. Each of the
Company and its Subsidiaries is in compliance in all material respects with all laws and
governmental rules and regulations applicable to its business, properties and assets, including,
without limitation, all such rules, laws and regulations relating to fair employment practices,
occupational safety and health and public safety. Neither the Company nor any Subsidiary (i) is
subject to any material judgment, consent decree, compliance order or administrative order with
respect to any aspect of the business, affairs, properties or assets of the Company or such
Subsidiary, (ii) has, since December 31, 2004, received any written request for information,
notice, demand letter or administrative inquiry with respect to any aspect of the business,
affairs, properties or assets of the Company or such Subsidiary relating to any matter which, in
the case of this clause (ii) would reasonably be expected to have a Material Adverse Effect, or
(iii) has, since December 31, 2004, received any formal or informal complaint or claim from any
regulatory agency with respect to any material aspect of the business, affairs, properties or
assets of the Company or such Subsidiary.

     3.28 Broker or Finders. The Company has not incurred, nor will incur, directly or indirectly, as a
result of any action taken by the Company, any liability for brokerage or finders’ fees or agents’
commissions or any similar charges in connection with this Agreement.

     3.29 Market Listing. The Common Stock is listed for trading on the NASDAQ National Market and the
Company is in compliance with the rules, regulations and requirements of the NASDAQ National Market
relating to the continued listing of the Common Stock.

     3.30 Related Party Transactions. Except with respect to the transactions that are not required to
be disclosed, all transactions that have occurred between or among the Company, on the one hand,
and any of its officers or directors, or any affiliate or affiliates of any such officer or
director, on the other hand, prior to the date hereof have been disclosed in the Company SEC
Documents.

     3.31 No Material Adverse Effect. Since September 30, 2005, no event or events have occurred that
have had or would, individually or in the aggregate, reasonably be expected to have, a Material
Adverse Effect.

4. Representations and Warranties of the Investor. The Investor hereby represents and warrants to
the Company that the statements contained in Section 4 are true and correct as of the date hereof
and as of the Closing Date:

     4.1 Authorization, Governmental Consents and Compliance with Other Instruments. All corporate
action on the part of the Investor necessary for the authorization, execution and delivery of this
Agreement and the Investor Rights Agreement Amendment and the performance of all obligations of the
Investor hereunder and under the Investor Rights Agreement has been taken or will be taken prior to
the Closing. Each of this Agreement and the Investor Rights Agreement constitute a valid and
legally binding obligation of the Investor,

11

 

enforceable in accordance with its terms, except as such enforceability may be limited by
applicable bankruptcy, insolvency, reorganization, moratorium or other laws of general application
relating to or affecting enforcement of creditors rights or by equitable principles and except as
rights to indemnity and contribution may be limited by state or federal securities laws or public
policy underlying such laws. No consent, approval, order or authorization of, or registration,
qualification, designation, declaration or filing with, any federal, state or local Governmental
Authority on the part of the Investor is required in connection with the consummation of the
transactions contemplated by this Agreement and the Investor Rights Agreement, except for filings
required pursuant to securities laws. The execution, delivery and performance of this Agreement
and the Investor Rights Agreement Amendment and the consummation of the transactions contemplated
hereby and thereby will not result in any violation or be in conflict with or constitute, with or
without the passage of time and giving of notice, either a default under any provision of the
Investor’s corporate charter or bylaws or any instrument, judgment, order, writ, decree or contract
to which the Investor is a party or by which it is bound.

     4.2 Purchase Entirely for Own Account. By the Investor’s execution of this Agreement, the Investor
hereby confirms that the Shares will be acquired for investment for the Investor’s own account, not
as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and
the Investor has no present intention of selling, granting any participation, or otherwise
distributing the Shares.

     4.3 Disclosure of Information. The Investor has received all the information from the Company and
its management that the Investor considers necessary or appropriate for deciding whether to
purchase the Shares hereunder. The Investor further represents that it has had an opportunity to
ask questions and receive answers from the Company regarding the terms and conditions of the
offering of the Shares. Neither the foregoing nor any information disclosed to the Investor shall
limit or modify the representations and warranties of the Company in Section 3 of this Agreement.

     4.4 Investment Experience and Accredited Investor Status. The Investor is an accredited investor
(as defined in Regulation D promulgated under the Securities Act) and is not acquiring the Shares
for the account or benefit of any United States Person. The Investor is an investor in securities
of companies in the development stage and acknowledges that it is able to fend for itself, and bear
the economic risk of its investment and has such knowledge and experience in financial or business
matters that it is capable of evaluating the merits and risks of the investment in the Shares
hereunder.

     4.5 No Governmental Review. The Investor understands that no United States federal or state agency
or any other government or governmental agency has passed upon or made any recommendation or
endorsement of the Shares or an investment therein.

     4.6 Residency. The Investor is a resident of Switzerland.

     4.7 Foreign Investors. If the Investor is not a United States person (as defined by Section
7701(a)(30) of the Code), the Investor hereby represents that it has satisfied itself as to the
full observance of the laws of its jurisdiction in connection with any invitation to subscribe

12

 

for the Shares or any use of this Agreement, including (i) the legal requirements within its
jurisdiction for the purchase of the Shares, (ii) any foreign exchange restrictions applicable to
such purchase, (iii) any government or other consents that may need to be obtained, and (iv) the
income tax and other tax consequences, if any, that may be relevant to the purchase, holding,
redemption, sale or transfer of the Shares. The Company’s offer and sale and the Investor’s
subscription and payment for and continued beneficial ownership of the Shares will not violate any
applicable securities or other laws of the Investor’s jurisdiction.

     4.8 No Short Sales. Prior to the date hereof, Investor has not engaged in any short sales or
similar transactions with respect to shares of Common Stock, nor has the Investor, directly or
indirectly, caused any Person to engage in any short sales or similar transactions with respect to
shares of Common Stock.

     4.9 Restricted Securities. The Investor understands that the Shares, when issued, will be
restricted securities under the federal securities laws inasmuch as they are being acquired from
the Company in a transaction not involving a public offering and that under such laws and
applicable regulations, such securities may be resold without registration under the Securities Act
only in certain limited circumstances. The Investor understands that the Shares will not be
registered under the Securities Act by reason of a specific exemption therefrom, that such
securities must be held by it indefinitely and that the Investor must, therefore, bear the economic
risk of such investment indefinitely, unless a subsequent disposition thereof is registered under
the Securities Act or is exempt from such registration. In this respect, the Investor represents
that it is familiar with Rule 144, as presently in effect, and understands the resale limitations
imposed thereby and by the Securities Act.

     4.10 Legends. It is understood that the certificates evidencing the Shares will bear any legend
required to be placed thereon under applicable state securities laws, any lock-up legend or legend
referring to any restriction on transfer or sale (solely for so long as the Shares are subject to
such lock-up or restriction, as applicable), and the following legend until such legend is removed
in accordance with Section 8.1:

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED.
THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN
THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES UNDER SUCH
ACT OR AN EXEMPTION FROM SUCH REGISTRATION AS PROVIDED FOR IN SUCH ACT.

Investor acknowledges that the Company will instruct the Company’s transfer agent not to register
the transfer of the Shares (or any portion thereof) during any period in which the Shares are
subject to a lock-up or other restriction on transfer. The Securities Act legend shall not be
removed from the Shares unless the conditions specified in Section 8.1 for the removal of such
legend are satisfied.

5. Conditions to Closing of Investor. The Investor’s obligation to purchase the Shares and
consummate the other transactions contemplated hereby at the Closing is subject to the

13

 

fulfillment as of the Closing of the following conditions (unless waived in writing by the
Investor):

     5.1 Representations and Warranties Correct. The representations and warranties made by the Company
in Section 3 hereof shall be true and correct in all respects as of the date of this Agreement, and
as of the Closing Date with the same force and effect as though such representations and warranties
had been made on such Closing Date.

     5.2 Covenants. All covenants, agreements and conditions contained in this Agreement and the
Investor Rights Agreement to be performed by the Company on or prior to the Closing Date shall have
been performed or complied with in all material respects.

     5.3 Compliance Certificate. The Company shall have delivered to the Investor a certificate, dated
as of the Closing Date, executed by the President and Chief Executive Officer of the Company,
certifying to the fulfillment of the conditions specified in Sections 5.1 and 5.2 of this
Agreement.

     5.4 Certification of Resolutions and Officers. The Company shall have delivered to the Investor a
certificate or certificates, dated the Closing Date, of the Secretary of the Company certifying as
to (a) the resolutions of the Company’s Board of Directors authorizing the execution and delivery
of this Agreement and the Investor Rights Agreement Amendment, the issuance of the Shares to the
Investor, the execution and delivery of such other documents and instruments as may be required by
this Agreement or the Investor Rights Agreement and the consummation of the transactions
contemplated hereby and thereby and certifying that such resolutions were duly adopted and have not
been rescinded or amended as of said date, (b) the name and the signature of the officers of the
Company authorized to sign, as appropriate, this Agreement, the Investor Rights Agreement Amendment
and the other documents and certificates to be delivered pursuant to this Agreement or the Investor
Rights Agreement by either the Company or any of its officers, and (c) a specimen certificate
representing the Shares.

     5.5 Organizational Documents. The Company shall have delivered to the Investor copies of (i) the
Certificate of Incorporation, certified by the Secretary of State of Delaware as of a date not
earlier than five (5) business days prior to the Closing Date and accompanied by a certificate of
the Secretary of the Company, dated as of the Closing Date, stating that no amendments have been
made to such Certificate of Incorporation since such date, and (ii) the Bylaws of the Company
certified by the Secretary of the Company.

     5.6 Good Standing Certificate. The Company shall have delivered to the Investor (i) a good
standing certificate dated as of a date not earlier than five (5) business days prior to the
Closing Date issued with respect to the Company and each of its Subsidiaries by the Secretary of
State of Delaware and (ii) good standing certificates as of a date not earlier than five (5)
business days prior to the Closing Date issued with respect to the Company by the Secretary of
State of California.

     5.7 Cross Receipt. The Company shall have delivered to the Investor a duly executed Cross Receipt
setting forth the number of Shares, the Share Price and the Purchase

14

 

Price determined in accordance with Section 1.1 substantially in the form of Exhibit A
attached hereto.

     5.8 Other Agreements. The Company shall have delivered to the Investor the duly executed License
and Collaboration Agreement and the Investor Rights Agreement Amendment and such agreements shall
be in full force and effect.

     5.9 Proceedings and Documents. All corporate and other proceedings to have been taken and all
waivers and consents to be obtained in connection with the transactions contemplated by this
Agreement and the Ancillary Agreements shall have been taken or obtained, and all documents
incidental hereto and thereto shall be satisfactory to the Investor and its counsel.

     5.10 Continued Market Listing. On the Closing Date, the Common Stock shall be listed for trading
on the NASDAQ National Market and the Shares shall be approved for listing on the NASDAQ National
Market.

     5.11 Registration Rights Consent. The Company shall have delivered written consents from the
requisite parties to the Investor Rights Agreement consenting to the rights granted to the Investor
in the Investor Rights Agreement Amendment, such written consents to be in form and substance
reasonably acceptable to the Investor and sufficient to effectively amend the Investor Rights
Agreement in accordance with its terms.

6. Conditions to Closing of the Company. The Company’s obligation to sell the Shares and
consummate the other transactions contemplated hereby at the Closing is subject to the fulfillment
as of the Closing of the following conditions:

     6.1 Representations and Warranties Correct. The representations and warranties made by the
Investor in Section 4 hereof shall be true and correct in all respects as of the date of this
Agreement, and as of the Closing Date with the same force and effect as though such representations
and warranties had been made on such date.

     6.2 Cross Receipt. The Investor shall have delivered to the Company a duly executed Cross Receipt
setting forth the number of Shares, the Share Price and the Purchase Price determined in accordance
with Section 1.1 substantially in the form of Exhibit A attached hereto.

     6.3 Other Agreements. The Investor shall have delivered to the Company the duly executed License
and Collaboration Agreement and the Investor Rights Agreement Amendment and such agreements shall
be in full force and effect.

     6.4 Lock-Up Agreement. The Investor shall have delivered to the Company a duly executed lock-up
letter substantially in the form of Exhibit C attached hereto.

7. Mutual Conditions to Closing. The obligations of each of the Investor and the Company to
consummate the Closing are subject to the fulfillment as of the Closing Date of the following
conditions:

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     7.1 Qualifications. All authorizations, consents, waivers, permits, approvals, qualifications and
registrations required to be obtained or effected with any Governmental Authority prior to the
Closing Date shall have been duly obtained and be effective as of the Closing Date.

     7.2 Absence of Litigation. There shall be no injunction, action, suit, proceeding or investigation
pending or currently threatened in writing against the Company or the Investor which questions the
validity of this Agreement or the Investor Rights Agreement Amendment, or the right of the Company
or the Investor to enter into this Agreement or the Investor Rights Agreement or to consummate the
transactions contemplated hereby or thereby.

8. Additional Covenants and Agreements.

     8.1 Share Legend Removal. The Securities Act legend set forth in Section 4.10 hereof shall be
removed from the certificate evidencing the Shares and the Company shall, or shall cause its
transfer agent to, issue, no later than two (2) business days from receipt of a request from the
Investor pursuant to this Section 8.1, a certificate or certificates evidencing all or a portion of
the Shares, as requested by the Investor, without such legend if: (i) such securities have been
resold under an effective registration statement under the Securities Act, (ii) such securities
have been transferred in compliance with Rule 144 under the Securities Act, (iii) such securities
are eligible for resale pursuant to Rule 144(k) under the Securities Act or (iv) the Investor shall
have provided the Company with an opinion of counsel, reasonably satisfactory to the Company,
stating that such securities may lawfully be transferred without registration under Rule 144(k)
promulgated under the Securities Act.

     8.2 Use of Proceeds. The Company shall use the proceeds from the sale of the Shares for working
capital and other general corporate purposes.

     8.3 Standstill Agreement.

          (a) Provided that nothing contained herein will prevent or prohibit the Investor from
acquiring the Shares or any other securities of the Company to be acquired in connection with any
future collaboration agreement with the Company, the Investor will not, directly or indirectly,
without the prior consent of a majority of the Board of Directors of the Company (the
“Board”), (i) acquire (or offer or agree to acquire) any shares of Common Stock or
Preferred Stock possessing rights to vote together with Common Stock (each a “Company Equity
Security”); (ii) engage in any “solicitation” of “proxies” (as such terms are defined in
Regulation 14A under the Securities Exchange Act) or consents to vote any Company Equity Security;
or (iii) transfer to any third party (other than to its “affiliates,” “associates” (as such terms
are defined in Rule 12b-2 under the Securities Exchange Act), officers, directors or employees and
other than pursuant to a proxy solicitation conducted by or on behalf of the Board), the right to
vote any Company Equity Security except in connection with a sale by the Investor of such Company
Equity Security in a transaction not otherwise prohibited by this Agreement. The Investor also
agrees that it will not advise, assist or encourage any third party to do any of the foregoing.
Subject to Section 8.4, the covenants in this Section 8.3 shall remain in effect until the earlier
of (i) the second anniversary of the Closing Date and (ii) the termination of this Agreement.

16

 

          (b) Nothing contained herein shall prevent the Investor or its affiliates from (i) investing
in fixed income investments made in money-market mutual funds or direct debt investments, (ii)
acquiring any Company Equity Security if after such acquisition, the Investor and its affiliates
would “beneficially own” (as defined in Rule 13d-3 under the Securities Exchange Act) ten percent
(10%) or less of the voting power of the outstanding Company Equity Securities, provided, that it
shall not be a violation of this Section 8.3 if the Investor and its affiliates beneficially own
more than ten percent (10%) of the voting power of the outstanding Company Equity Securities as a
result of any share repurchase, redemption, cancellation or other change in the Company’s capital
structure reducing the number or altering the voting power of the outstanding Company Equity
Securities, (iii) acquiring Company Equity Securities distributed or issued with respect to or in
exchange for any Company Equity Securities beneficially owned by the Investor or its affiliates or
distributed or issued with respect thereto or in exchange therefor without any cash payment
therefor, (iv) acquiring securities of any biotechnology or pharmaceutical company that
beneficially owns Company Equity Securities or (v) making any request to the Board to amend or
waive any of the restrictions set forth in this Section 8.3.

     8.4 Termination of Standstill. Notwithstanding the foregoing, the obligations of the Investor
under Section 8.3 shall terminate in the event (i) of any bona fide third party tender or exchange
offer for at least 50% of the voting power of the outstanding Company Equity Securities, (ii) the
Company enters into any agreement to merge, consolidate or enter into a business combination or
other extraordinary corporate transaction with any Person not affiliated with the Investor in which
the holders of the outstanding Company Equity Securities immediately prior to such merger,
consolidation, business combination or other transaction (other than the beneficial owners of such
Person, if applicable) hold less than a majority of the voting power of the outstanding voting
securities of the surviving or resulting company, (iii) the Company enters into any agreement to
sell all or substantially all of its assets to any Person not affiliated with the Investor, (iv)
any Person not affiliated with the Investor acquires Company Equity Securities which, together with
any Company Equity Securities previously owned by such Person, represent more than twenty-five
percent (25%) of the voting power of the outstanding Company Equity Securities, or (v) the
individuals who on the date hereof constituted the Board (together with any new directors whose
election by the Board or nomination for election by the stockholders of the Company was approved by
a majority of the directors of the Company then still in office or whose election or nomination for
election was previously so approved by the directors in office on the date hereof, other than any
director designated by any Person that has made a tender or exchange offer described in clause (i)
above or has entered into an agreement described in clause (ii) or (iii) above) ceasing for any
reason to constitute a majority of the Board. All of the provisions of Section 8.3 shall be
reinstated and shall apply in full force according to their terms in the event that: (x) if the
provisions of Section 8.3 shall have terminated as the result of a tender or exchange offer, such
tender or exchange offer (as originally made or as amended or modified) shall have terminated
(without closing) prior to the commencement of a tender or exchange offer by the Investor that
would have been permitted to be made pursuant to the first sentence of this Section 8.4 as a result
of such third-party tender or exchange offer; (y) any tender or exchange offer by the Investor (as
originally made or as extended or modified) that was permitted to be made pursuant to this Section
8.4 shall have terminated (without closing); or (z) if the provisions of Section 8.3 shall have
terminated as a result of any action by the Company referred to in this Section 8.4, the Company
shall have

17

 

determined, prior to the taking of any action by the Investor that would have been permitted to be
made pursuant to the first sentence of this Section 8.4 as a result of such Company action, not to
take any of such actions (and no such transaction shall have closed). Upon reinstatement of the
provisions of Section 8.3, the provisions of this Section 8.4 shall continue to govern in the event
that any of the events described in this Section 8.4 shall occur.

     8.5 Share Ownership. In the event the Investor becomes a beneficial owner of more than 19% of the
outstanding voting equity securities of the Company (other than as a result of the Investor’s
purchase of additional shares of Common Stock of the Company after the date hereof), upon written
request of the Investor, the Company shall (i) release any contractual limitation or restriction in
favor of the Company, if any, on the sale or transfer of shares with respect to a sufficient number
of shares of voting equity securities held by the Investor to permit the Investor to reduce the
Investor’s beneficial ownership of the Company’s voting equity securities to 19% of the voting
equity securities of the Company then outstanding, and (ii) cooperate with the Investor to permit
the Investor to effect such sale or transfer provided such sale or transfer is made in compliance
with applicable securities laws.

9. Miscellaneous.

     9.1 Termination. This Agreement may be terminated at any time prior to the Closing:

          (a) By mutual written agreement of the Company and the Investor;

          (b) By either the Company or the Investor, by written notice to the other party (provided the
terminating party is not then in material breach of any representation, warranty, covenant or other
agreement contained in this Agreement if the Closing shall not have been consummated on or before
April 30, 2006; or

          (c) By either the Company or the Investor by giving written notice to the other party if any
governmental entity shall have issued an injunction or other ruling prohibiting the consummation of
any of the transactions contemplated by this Agreement, the Investor Rights Agreement or the
License and Collaboration Agreement and such injunction or other ruling shall not be subject to
appeal or shall have become final and unappealable.

     9.2 Effect of Termination. In the event of any termination of this Agreement pursuant to Section
9.1, all rights and obligations of the parties hereunder shall terminate without any liability on
the part of any party or its Affiliates in respect thereof; provided, however, that (i) Sections
9.4, 9.5, 9.6, 9.7. 9.8, 9.13, 9.14 and 9.17 shall survive any such termination and (ii) such
termination shall not relieve the Company or the Investor of any liability on account of any
willful breach of this Agreement.

     9.3 Survival of Warranties. The representations and warranties of the Company and the Investor
contained in this Agreement shall survive the Closing until thirty (30) days after the Company has
filed its Annual Report on Form 10-K for the fiscal year ended December 31, 2006; provided however,
that the representations and warranties contained in Sections 3.2, 3.6 and 3.25 shall survive until
the expiration of the statute of limitations applicable to claims with respect to the matters
contained therein.

18

 

     9.4 Attorney’s Fees. In the event that a final, binding and non-appealable ruling by a court of
competent jurisdiction holds that the Company breached its obligations under this Agreement, the
Company shall pay all reasonable legal fees and expenses of the Investor.

     9.5 Remedies. In case any one or more of the covenants or agreements set forth in this Agreement
shall have been breached by any party hereto, the party or parties entitled to the benefit of such
covenants or agreements may proceed to protect and enforce their rights either by suit in equity or
action at law, including, but not limited to, an action for damages as a result of any such breach
or an action for specific performance of any such covenant or agreement contained in this
Agreement. The rights, powers and remedies of the parties under this Agreement are cumulative and
not exclusive of any other right, power or remedy which such parties may have under any other
agreement or law. No single or partial assertion or exercise of any right, power or remedy of a
party hereunder shall preclude any other or further assertion or exercise thereof.

     9.6 Successors and Assigns. Except as otherwise expressly provided herein, the terms and
conditions of this Agreement shall inure to the benefit of and be binding upon the respective
successors and permitted assigns of the parties, including, without limitation, successors through
merger, consolidation, reorganization, recapitalization, any similar transaction or otherwise.
Neither this Agreement nor any rights or duties of a party hereto may be assigned by the Company,
in whole or in part, without the prior written consent of the Investor, except in a sale to a
purchaser of the Company’s business, whether by way of a sale of all or substantially all of the
Company’s assets, merger, business combination or otherwise. This Agreement or any rights and/or
obligations hereunder may be assigned by the Investor without the prior written consent of the
Company; provided, however, that until the earlier of (i) the second anniversary of
the date hereof and (ii) the termination of the License and Collaboration Agreement, the Investor
may not assign any claim for breach of this Agreement or its obligations under Section 8.3 hereof,
other than (x) to an Affiliate of the Investor, (y) to any permitted assignee of the obligations
under the License and Collaboration Agreement or an Affiliate thereof, or (z) in connection with
the sale of a division or business unit by the Investor or any Affiliate thereof.

     9.7 Entire Agreement. This Agreement and the annexes, exhibits and schedules hereto which form a
part hereof contain the entire agreement among the parties with respect to the subject matter
hereof and thereof and supersede all prior and contemporaneous arrangements or understandings,
whether written or oral, with respect thereto; provided, however, that this Agreement is not
intended to supersede the License and Collaboration Agreement.

     9.8 Governing Law and Consent to Jurisdiction. This Agreement shall be governed by and construed
under the laws of the State of New York (without regard to the conflict of law principles thereof).

     9.9 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall
be deemed an original, but all of which together shall constitute one and the same instrument.

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     9.10 Titles and Subtitles. The titles and subtitles used in this Agreement are used for
convenience only and are not to be considered in construing or interpreting this Agreement.

     9.11 Nouns and Pronouns. Whenever the context may require, any pronouns used herein shall include
the corresponding masculine, feminine or neuter forms, and the singular form of names and pronouns
shall include the plural and vice-versa.

     9.12 Notices. Unless otherwise provided, all notices, requests, consents and other communications
hereunder to any party shall be given in writing and shall be deemed effectively given upon
personal delivery to the party to be notified or five business days after being duly sent by first
class registered or certified mail, or other courier service, postage prepaid, or the following
business day after being telecopied with a confirmation copy by regular mail, and addressed or
telecopied to the party to be notified at the address or telecopier number indicated for such
party, as the case may be, set forth below or such other address or telecopier number, as the case
may be, as may hereafter be designated in writing by the addressees to the addressor listing all
parties:

     To the Company:

SGX Pharmaceuticals, Inc.

10505 Roselle Street

San Diego, California 92121

Attention: Chief Financial Officer

Attention: Legal Department

Fax:
          (858) 558-4859

     With a copy (which shall not constitute notice) to:

Cooley Godward llp

4401 Eastgate Mall

San Diego, CA 92121

Attention: Kay Chandler

Fax:
          (858) 550-6420

     To the Investor:

Novartis Pharma AG

Lichtstrasse 35

CH-4002 Basel

Switzerland

Attention: Joseph E. Mamie

Fax:
         41 61 324 8111

     With a copy (which shall not constitute notice) to:

Novartis Institutes for BioMedical Research, Inc.

400 Technology Square

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Cambridge, Massachusetts 02139

Attention: Robert L. Thompson, Vice President and General Counsel

Fax:
          (617) 871-3354

     With a copy (which shall not constitute notice) to:

Kaye Scholer LLP

425 Park Avenue

New York, New York 10022

Attention: Adam H. Golden, Esq.

Fax:
          (212) 836-8689

     9.13 Finder’s Fee. The Investor agrees to indemnify and to hold harmless the Company from any
liability for any commission or compensation in the nature of a finder’s fee (and the reasonable
costs and expenses of defending against such liability or asserted liability) for which the
Investor or any of its officers, partners, employees, or representatives is responsible. The
Company agrees to
indemnify and hold harmless the Investor from any liability for any commission or compensation in
the nature of a finder’s fee (and the reasonable costs and expenses of defending against such
liability or asserted liability) for which the Company or any of its officers, employees or
representatives is responsible.

     9.14 Expenses. Except as otherwise contemplated herein, each party shall pay its own fees and
expenses with respect to this Agreement.

     9.15 Amendments and Waivers. Any term of this Agreement may be amended and the observance of any
term of this Agreement may be waived (either generally or in a particular instance and either
retroactively or prospectively), only with the written consent of the Company and the Investor
(other than the waiver of any condition set forth in Section 5, which may be waived in the sole
discretion of the Investor, and other than the waiver of any condition set forth in Section 6,
which may be waived in the sole discretion of the Company).

     9.16 Severability. If one or more provisions of this Agreement are held to be unenforceable under
applicable law, in any jurisdiction, such provision shall be ineffective, as to such jurisdiction,
and the balance of the Agreement shall be interpreted as if such provision were so excluded,
without invalidating the remaining provisions of this Agreement; and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in
any other jurisdiction.

     9.17 Confidentiality and Publicity.

          (a) All confidential information disclosed by a party hereto or its Affiliates to the other
party hereto or its Affiliates under this Agreement will be maintained in confidence and otherwise
safeguarded by the recipient party. Each party shall hold as confidential such confidential
information of the other party or its Affiliates in the same manner and with the same protection as
such recipient party maintains its own confidential information, but no less than a reasonable
standard of care. A recipient party may only disclose confidential information of the other party
to employees, agents, contractors, consultants and advisers of the party and its Affiliates,
licensees and sublicensees; provided that such persons are bound to maintain the

21

 

confidentiality of
the confidential information in a manner consistent with the confidentiality provisions of this
Agreement. The mutual obligations under this Section 9.17 shall not apply to any information to
the extent the recipient party can demonstrate by competent evidence that such information: (i) is
(at the time of disclosure) or becomes (after the time of disclosure) known to the public or part
of the public domain through no breach of this Agreement by the recipient party or its Affiliates;
(ii) was known to, or was otherwise in the possession of, the recipient party or its Affiliates
prior to the time of disclosure by the disclosing party; (iii) is disclosed to the recipient party
or an Affiliate on a non-confidential basis by a third party who is entitled to disclose it without
breaching any confidentiality obligation to the disclosing party or
any of its Affiliates; or (iv) is independently developed by or on behalf of the recipient
party or its Affiliates, as evidenced by its written records, without reference to the confidential
information disclosed by the disclosing party or its Affiliates under this Agreement. In addition
to disclosures allowed hereunder, each party hereto may disclose confidential information belonging
to the other party to the extent such disclosure is necessary in the following instances: (i)
complying with applicable court orders or governmental regulations; and (ii) disclosure to
consultants, investors, bankers, lawyers, accountants, agents or other third parties in connection
with due diligence or similar investigations by such third parties, provided, in each case, that
any such consultant, investor, banker, lawyer, accountant, agent or third party is bound to
maintain the confidentiality of the confidential information in a manner consistent with the
confidentiality provisions of this Agreement.

          (b) Each party hereto agrees not to issue any press release or other public statement, whether
oral or written, disclosing the existence of this Agreement, the terms hereof or any information
relating to this Agreement without the prior written consent of the other party; provided however,
that neither party hereto will be prevented from complying with any duty of disclosure it may have
pursuant to law or governmental regulation or pursuant to the rules of any recognized stock
exchange or quotation system. A party hereto who desires to issue a press release or make any
other public disclosure relating to this Agreement shall notify the other in writing at least ten
(10) business days (or such shorter period where legally required) before the time of the proposed
release. Such party shall provide a draft of any of the proposed documents containing any such
reference (including without limitation, a copy of this Agreement or any excerpt hereof, proposed
to be filed with any securities regulatory authority or any securities exchange) to the other party
and its counsel in sufficient time for review of such documents. In the event such other party
objects to any such reference, the applicable document will be modified to such party’s reasonable
satisfaction.

     9.18 Definitions. As used in this Agreement, the following terms shall have the following
meanings:

     “2005 Unaudited Financial Statements” shall have meaning set forth in Section 3.15(a).

     “Affiliate” shall mean, with respect to any Person, any other Person that directly or
indirectly, by itself or through one or more intermediaries, controls, or is controlled by, or is
under common control with, such Person. The term “control” means the possession, direct or
indirect, of the power to direct or cause the direction of the management and policies of a Person,
whether through the ownership of voting securities, by contract or otherwise. Control will be

22

 

presumed if one Person owns, either of record or beneficially, at least 50% of the voting stock of
any other Person.

     “Audited Financial Statements” shall have the meaning set forth in Section 3.15(a).

     “Board” shall have the meaning set forth in Section 8.3(a).

     “Certificate of Incorporation” shall have the meaning set forth in Section 3.1.

     “Closing Date” shall have the meaning set forth in Section 2.1.

     “Closing” shall have the meaning set forth in Section 2.1.

     “Code” shall mean the U.S. Internal Revenue Code of 1986, as amended.

     “Common Stock” shall have the meaning set forth in Section 1.1(a).

     “Company” shall have the meaning set forth in the Preamble.

     “Company Equity Security” shall have the meaning set forth in Section 8.3(a).

     “Company Rights” shall have the meaning set forth in Section 3.11(a).

     “Company SEC Documents” shall have the meaning set forth in Section 3.15(b).

     “Disclosure Schedule” shall have the meaning set forth in the introductory paragraph
of Section 3.

     “Encumbrance(s)” shall mean any security interest, pledge, mortgage, lien (including,
without limitation, environmental and tax liens), charge, encumbrance, adverse claim, or
restriction of any kind, including, without limitation, any restriction on the use, voting,
transfer, receipt of income or other exercise of any attributes of ownership.

     “Environmental Law” shall have the meaning set forth in Section 3.25(a).

     “ERISA” shall have the meaning set forth in Section 3.18.

     “Financial Statements” shall have the meaning set forth in Section 3.15(a).

     “GAAP” shall have the meaning set forth in Section 3.15(a).

     “Governmental Authority” shall have the meaning set forth in Section 3.5(a).

     “Hazardous Materials” shall have the meaning set forth in Section 3.25(b).

     “Interim Financial Statements” shall have meaning set forth in Section 3.15(a).

     “Investment Company Act” shall have the meaning set forth in Section 3.23.

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     “Investor” shall have the meaning set forth in the Preamble and Section 1.1(c).

     “Investor Rights Agreement” shall mean that certain Amended and Restated Investor
Rights Agreement, dated as of April 21, 2005, by and among the Company and each of the investors
named therein, as amended by the First Amendment to Amended and Restated Investor Rights Agreement,
dated as of October 31, 2005, and by the Investor Rights Agreement Amendment.

     “Investor Rights Agreement Amendment” shall mean that certain Amendment to Amended and
Restated Investor Rights Agreement, dated as of the date hereof, by and between
the Company, the Investor and the other stockholders of the Company parties thereto, a copy of
which is attached as Exhibit B hereto.

     “License and Collaboration Agreement” shall mean that certain License and
Collaboration Agreement, dated as of the date hereof, between the Company and Novartis Institutes
for BioMedical Research, Inc.

     “Material Adverse Effect” shall have the meaning set forth in Section 3.1.

     “Material IP Contracts” shall have the meaning set forth in Section 3.11(b).

     “Novartis” shall have the meaning set forth in the Preamble.

     “Obligations” shall have the meaning set forth in Section 3.12(d).

     “Person” means any individual, partnership, firm, corporation, association, trust,
unincorporated organization, government or any department or agency thereof or other entity, as
well as any syndicate or group that would be deemed to be a Person under Section 13(d)(3) of the
Securities Exchange Act.

     “Preferred Stock” shall have the meaning set forth in Section 3.2(a)(i).

     “Property” shall have the meaning set forth in Section 3.25(b).

     “Proprietary Rights” shall have the meaning set forth in Section 3.11(a).

     “Purchase Price” shall have the meaning set forth in Section 1.1(a).

     “Registration Statement” shall have the meaning set forth in the introductory
paragraph of Section 3.

     “Release” shall have the meaning set forth in Section 3.25(b).

     “SEC” shall mean the U.S. Securities and Exchange Commission.

     “Securities Act” shall have the meaning set forth in Section 3.13.

     “Securities Exchange Act” shall have the meaning set forth in Section 3.26.

24

 

     “Securities Laws” shall have the meaning set forth in Section 3.26.

     “Shares” shall have the meaning set forth in Section 1.1(a).

     “Share Price” shall have the meaning set forth in Section 1.1(b).

     “Subsidiary” shall mean any and all corporations, partnerships, joint ventures,
associations and other entities controlled by the Company directly or indirectly through one or
more intermediaries.

25

 

     IN WITNESS WHEREOF, the parties have executed and delivered this Agreement as of the date
first above written.

	 	 	 	 	 	 	 
	 	 	NOVARTIS PHARMA AG	 	 
	 
	 	 	 	 	 	 
	 

	 	By:

Name:
	 	/s/ Joseph E. Mamie
 

Joseph E. Mamie
	 	 
	 

	 	Title:
	 	Head Operational Treasury	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Dr. Matthias S. Runge	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Dr. Matthias S. Runge	 	 
	 

	 	Title:
	 	Head Legal Pharma Ophthalmics & Oncology

Region Europe	 	 
	 
	 	 	 	 	 	 
	 	 	SGX PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Michael Grey	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Michael Grey	 	 
	 

	 	Title:
	 	President and Chief Executive Officer	 	 

[SIGNATURE PAGE TO STOCK PURCHASE AGREEMENT]

 

 

Annex A

Disclosure Schedule

(Delivered herewith)

 

 

Exhibit A

Cross Receipt

SGX PHARMACEUTICALS, INC.

637,755 SHARES OF COMMON STOCK

CROSS-RECEIPT

     Reference is made to the Stock Purchase Agreement, dated as of March 27, 2006 (the
“Purchase Agreement”), by and between SGX Pharmaceuticals, Inc., a Delaware corporation
(the “Company”) and Novartis Pharma AG, a corporation organized under the laws of
Switzerland (“Novartis”).

     Capitalized terms used but not defined herein shall have the meanings set forth in the
Purchase Agreement.

     1. Novartis hereby acknowledges receipt of an aggregate of 637,755 shares of the Company’s
common stock, par value $0.001 per share (the “Shares”).

     2. The Company hereby acknowledges receipt from Novartis in Federal or other immediately
available funds by wire transfer in the aggregate amount of U.S. $5,000,000.00 (the “Purchase
Price”) to purchase and pay for the Shares delivered by the Company at a per share price of
$7.84 (the “Share Price”) pursuant to Section 1.1 of the Purchase Agreement.

 

 

Dated: March 27, 2006

New York, New York

	 	 	 	 	 	 	 
	 	 	SGX PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:

Name:
	 	/s/ Michael Grey
 

Michael Grey
	 	 
	 

	 	Title:
	 	President and Chief Executive Officer	 	 
	 
	 	 	 	 	 	 
	 	 	NOVARTIS PHARMA AG	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Joseph E. Mamie	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Joseph E. Mamie	 	 
	 

	 	Title:
	 	Head Operational Treasury	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Dr. Matthias S. Runge	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Dr. Matthias S. Runge	 	 
	 

	 	Title:
	 	Head Legal Pharma Ophthalmics &

Oncology Region Europe	 	 

[Signature to Cross Receipt]

 

 

Exhibit B

Investor Rights Agreement Amendment

 

 

Exhibit C

Lock-Up Agreement

LOCK-UP AGREEMENT

March 27, 2006

CIBC World Markets Corp.

Piper Jaffray & Co.

JMP Securities LLC

As Representative of the Several Underwriters

c/o CIBC World Markets Corp.

300 Madison Avenue

New York, New York 10017

     Re: Public Offering of SGX Pharmaceuticals, Inc.

Ladies and Gentlemen:

     The undersigned, a holder of common stock, par value $0.001 per share (“Common Stock”) or
rights to acquire Common Stock of SGX Pharmaceuticals, Inc. (the “Company”), understands that you,
as Representative of the several Underwriters, propose to enter into an Underwriting Agreement (the
“Underwriting Agreement”) with the Company, providing for the public offering (the “Public
Offering”) by the several Underwriters named in Schedule I to the Underwriting Agreement (the
“Underwriters”), of shares of Common Stock of the Company (the “Securities”). Capitalized terms
used herein and not otherwise defined shall have the meanings set forth in the Underwriting
Agreement.

     In consideration of the Underwriters’ agreement to enter into the Underwriting Agreement and
to proceed with the Public Offering of the Securities, and for other good and valuable
consideration receipt of which is hereby acknowledged, the undersigned hereby agrees for the
benefit of the Company, you and the other Underwriters that, without the prior written consent of
CIBC World Markets Corp. on behalf of the Underwriters, the undersigned will not, during the period
ending 180 days after the date of the prospectus relating to the Public Offering (the “Lock-Up
Period”), directly or indirectly (1) offer, pledge, assign, encumber, announce the intention to
sell, sell, contract to sell, sell any option or contract to purchase, purchase any option or
contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose
of, any shares of Common Stock of the Company or any securities convertible into or exercisable or
exchangeable for Common Stock owned either of record or beneficially (as defined in the Securities
Exchange Act of 1934, as amended (the “Exchange Act”)) by the undersigned on the date hereof or
hereafter acquired or (2) enter into any swap or other agreement that transfers, in whole or in
part, any of the economic consequences of ownership of the Common Stock, whether any such
transaction described in clause (1) or (2) above is to be settled by delivery of Common Stock or
such other securities, in cash or otherwise, or publicly announce an intention

 

 

to do any of the foregoing. In addition, the undersigned agrees that, without the prior written
consent of CIBC World Markets Corp. on behalf of the Underwriters, it will not, during the Lock-Up
Period, make any demand for or exercise any right with respect to, the registration of any shares
of Common Stock or any security convertible into or exercisable or exchangeable for Common Stock.
The foregoing shall not apply to: (i) the sale of the Securities to be sold pursuant to the
prospectus relating to the Public Offering; (ii) sales under any 10b-5 plan; or (iii) transfers of
Common Stock (A) as a bona fide gift or gifts, (B) to any trust for the direct or indirect benefit
of the undersigned or the immediate family of the undersigned, (C) if the undersigned is a
corporation, to any “affiliate” (as such term is defined in Rule 12b-2 promulgated under the
Exchange Act) of such corporation, (D) if the undersigned is a limited liability company, to a
member or affiliated limited liability company, or (E) if the undersigned is a partnership, to a
partner or affiliated partnership; provided, however, that in each such case under
clause (iii) above, (1) it shall be a condition to the transfer that the donee or transferee
execute an agreement stating that the donee or transferee is receiving and holding such capital
stock subject to the provisions of this Lock-Up Agreement and there shall be no further transfer of
such capital stock except in accordance with this Lock-Up Agreement, (2) any such transfer shall
not involve a disposition for value, (3) no filing by any party (donor, donee, transferor or
transferee) under the Exchange Act shall be required or shall be voluntarily made in connection
with such transfer (other than a filing on a Form 5, Schedule 13D (or amendment thereto) or
Schedule 13G (or amendment thereto)), (4) each party (donor, donee, transferor or transferee) shall
not be required by law (including without limitation the disclosure requirements of the Securities
Act of 1933, as amended (the “Securities Act”), and the Exchange Act) to make, and shall agree to
not voluntarily make, any public announcement of the transfer or disposition, and (5) the
undersigned notifies CIBC World Markets Corp. at least two business days prior to the proposed
transfer or disposition. For purposes of this Lock-Up Agreement, “immediate family” shall mean any
relationship by blood, marriage or adoption, not more remote than first cousin.

     Notwithstanding the foregoing, if (1) during the last 17 days of the Lock-Up Period the
Company issues an earnings release or material news or a material event relating to the Company
occurs; or (2) prior to the expiration of the Lock-Up Period, the Company announces that it will
release earnings results during the 16-day period beginning on the last day of the Lock-Up Period,
the restrictions imposed in this Lock-Up Agreement shall continue to apply until the expiration of
the 18-day period beginning on the issuance of the earnings release or the occurrence of the
material news or material event; provided, however, that this sentence shall not
apply if the research published or distributed on the Company is compliant under Rule 139 of the
Securities Act and the Company’s securities are actively traded as defined in Rule 101(c)(1) of
Regulation M of the Exchange Act.

     In furtherance of the foregoing, the Company, and any duly appointed transfer agent for the
registration or transfer of the securities described herein, are hereby authorized to decline to
make any transfer of securities if such transfer would constitute a violation or breach of this
Lock-Up Agreement.

     The undersigned hereby represents and warrants that the undersigned has full power and
authority to enter into this Lock-Up Agreement. All authority herein conferred or agreed to be

 

 

conferred and any obligations of the undersigned shall be binding upon the successors, assigns,
heirs or personal representatives of the undersigned.

     The undersigned understands that, if the Underwriting Agreement does not become effective, or
if the Underwriting Agreement (other than the provisions thereof which survive termination) shall
terminate or be terminated prior to payment for and delivery of the Common Stock to be sold
thereunder, the undersigned shall be released form all obligations under this Lock-Up Agreement.

     The undersigned, whether or not participating in the Public Offering, understands that the
Underwriters are entering into the Underwriting Agreement and proceeding with the Public Offering
in reliance upon this Lock-Up Agreement.

[signature page follows]

 

 

     This Lock-Up Agreement shall be governed by and construed in accordance with the laws of the
State of New York, without regard to the conflict of laws principles thereof.

	 	 	 	 	 	 	 
	 	 	Very truly yours,	 	 
	 
	 	 	 	 	 	 
	 	 	NOVARTIS PHARMA AG	 	 
	 
	 	 	 	 	 	 
	 

	 	By:

Name:
	 	/s/ Joseph E. Mamie
 

Joseph E. Mamie
	 	 
	 

	 	Title:
	 	Head Operational Treasury	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Dr. Matthias S. Runge	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Dr. Matthias S. Runge	 	 
	 

	 	Title:
	 	Head Legal Pharma Ophthalmics &

Oncology Region Europe

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