Document:

Joint Development Agreement

 Exhibit 10.20 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange
Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406 

JOINT DEVELOPMENT AGREEMENT 
 This Joint Development Agreement (this “JDA”), is dated as of this 15th day of March, 2011 (“Effective Date”), by and between Genomatica, Inc., a Delaware corporation
with principal offices located at 10520 Wateridge Circle, San Diego, California 92121 (hereinafter referred to as “Genomatica”), and Tate & Lyle Ingredients Americas, Inc., a Delaware corporation with principal offices
located at 2200 East Eldorado Street, Decatur, Illinois 62521 (hereinafter referred to as “T&L”). 

RECITALS: 

WHEREAS, Genomatica has invented and developed proprietary technology and recombinant microorganisms to produce 1,4-butanediol
(“Bio-BDO”); 
 WHEREAS, T&L possesses expertise in wet milling of corn and other raw materials into sugar
and/or starch, in the fermenting of sugar and/or starch, and in the separating and refining of fermentation products into commercial products; 
 WHEREAS, Genomatica and T&L have evaluated the economic feasibility of a biological route for the manufacture of Bio-BDO; 
 WHEREAS, Genomatica and T&L mutually desire to join their respective strengths in a relationship for the joint development of a process for producing renewable Bio-BDO from dextrose feedstocks sourced
from a T&L facility that may lead to the commercialization of Bio-BDO; and 
 WHEREAS, each Party recognizes it may be
necessary or desirable to grant to the other Party access to certain intellectual property in order to carry out the objectives of this JDA. 
 NOW THEREFORE, Genomatica and T&L agree to the following terms and conditions: 

ARTICLE I 

DEFINITIONS 
 1.1. Previously Defined Terms. Each term defined in the preamble and the Recitals to this JDA shall have the meaning set forth above whenever used herein. 

1.2. Definitions. In addition to the terms defined in the preamble and the Recitals of this JDA, the following terms, whenever
used herein, shall have the meanings set forth below: 

  
 1. 

 1.2.1. “Affiliate” shall mean, with respect to any specified Person, any
other Person that directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, such specified Person, and for this purpose, “control,” “controlled by” and “common
control” shall mean the ownership and voting control of more than 50% of the outstanding voting securities or interest in capital or profits of such specified Person, or the right to direct or control the management or affairs of such specified
Person by contract or similar arrangement. Should a Person divest an Affiliate or should an Affiliate cease to satisfy this definition, such Affiliate’s rights and obligations under this JDA shall be terminated. 

1.2.2. “Background Intellectual Property” shall mean all Intellectual Property first conceived, reduced to practice
and/or otherwise acquired or obtained by a Party prior to the Effective Date or outside of the scope of the Joint Development Program and during the term of this JDA, including rights arising in the course of prosecution and maintenance of such
Intellectual Property, which such Party discloses or otherwise provides to the other Party for use in the Joint Development Program. 
 1.2.3. “Bio-BDO Field” shall mean the biological manufacture of Bio-BDO and the marketing and the sale of Bio-BDO, and includes research and development related to the foregoing.

 1.2.4. “Bioprocess” shall mean a process using microorganisms for the production of Bio-BDO. 

1.2.5. “By-Products” shall mean isolatable compounds or substances, other than Bio-BDO, produced by the Bioprocess.

 1.2.6. “Commercial Facility” shall have the meaning set forth in Section 2.1. 

1.2.7. “Commercialization Agreement” shall have the meaning set forth in Section 4.2.1. 

1.2.8. “Commercialization KPIs” shall have the meaning set forth in Section 3.2(b). 

1.2.9. “Commercialization Phase” shall mean activities related to the commercialization of Bio-BDO produced using the
Commercial Process in the Territory. 
 1.2.10. “Commercial Process” shall have the meaning set forth in
Section 2.1. 
 1.2.11. “Confidential Information” shall mean any and all proprietary information and
materials, in any form (written, oral, photographic, electronic, magnetic, or otherwise), including without limitation, information related to technical, business, and intellectual property matters, intellectual property including know-how, data,
trade secrets, and all documents and other physical materials relating to prototypes, materials, compositions, devices, methods, or procedures related to the research and development, 

  
 2. 

 
manufacture, use or sale of Bio-BDO. Confidential Information of a Party disclosed pursuant to the NDA shall be treated as Confidential Information under this JDA. The T&L Intellectual
Property shall be Confidential Information of T&L, and the Genomatica Intellectual Property shall be Confidential Information of Genomatica. 
 1.2.12. Corn Processing Agreement” shall have the meaning set forth in Section 3.4. 
 1.2.13. “Damages” shall have the meaning set forth in Section 12.1. 
 1.2.14. “Demonstration Facility” shall have the meaning set forth in Section 2.1. 
 1.2.15. “Demonstration Phase” shall have the meaning set forth in Section 2.1.2. 
 1.2.16. “Demonstration Plan” shall have the meaning set forth in Section 3.1(c). 
 1.2.17. “Development KPIs” shall have the meaning set forth in Section 3.1(a). 
 1.2.18. “Development Plan” shall mean the plan for activities to be conducted under the Joint Development Program which is set forth in Schedule 1.2.18, including the
deliverables, estimated timelines and budget associated with the Investigative Phase and an initial proposal for the Demonstration Plan, which Demonstration Plan may be amended by the JDC pursuant to Section 3.1(c). 

1.2.19. “Election Period” shall have the meaning set forth in Section 4.1. 

1.2.20. “Exclusivity Period” shall have the meaning set forth in Section 4.3. 

1.2.21. “Facilities” shall mean the Demonstration Facility and the Commercial Facility, collectively. 

1.2.22. “Genomatica Confidential Information” shall mean any Confidential Information of Genomatica. 

1.2.23. “Genomatica Intellectual Property” shall mean (a) all Background Intellectual Property owned or licensed
(with the right to grant licenses or sublicenses) by Genomatica, which claims or covers all or part of a Bioprocess, including the components (including Genomatica Microorganisms) used in a Bioprocess, (b) all Process Intellectual Property, and
(c) all JDA Intellectual Property owned by Genomatica. 
 1.2.24. “Genomatica Microorganism(s)” shall mean
microorganisms designated by Genomatica and identified in Schedule 1.2.24 (as may be updated by 

  
 3. 

 
Genomatica with written notice to T&L) and which may be supplied by Genomatica during the term of the Joint Development Program. 

1.2.25. “Intellectual Property” shall mean all (a) Patent Rights, (b) trademarks, service marks, domain names,
trade dress, logos, trade names, and corporate names and registrations and applications for registration thereof, (c) copyrights and registrations and applications for registration thereof, (d) computer software, data, and documentation,
(e) trade secrets and confidential business information, whether patentable or unpatentable and whether or not reduced to practice, know-how, manufacturing and production processes and techniques, research and development information,
copyrightable works, financial, marketing and business data, pricing and cost information, business and marketing plans and customer and supplier lists and information, (f) other proprietary rights relating to any of the foregoing, and
(g) copies and tangible embodiments thereof. 
 1.2.26. “Investigative Phase” shall have the meaning set
forth in Section 2.1.1. 
 1.2.27. “Investigative Phase Plan” shall mean the plan and budget for the
Investigative Phase included in the Development Plan. 
 1.2.28. “JDA Intellectual Property” shall mean all
Intellectual Property first conceived, reduced to practice and/or otherwise acquired or obtained solely by a Party or jointly by the Parties in the course of and during the term of the Joint Development Program, including rights arising in the
course of prosecution and maintenance of such Intellectual Property, but excluding all Process Intellectual Property. 
 1.2.29.
“Joint Development Committee” shall mean the joint committee established pursuant to Article V. 
 1.2.30.
“Joint Development Program” shall mean the joint program undertaken by the Parties under this JDA as described in Articles II and III. 
 1.2.31. “Law” shall mean any federal, state, regional, local, or foreign law, constitution, rule, statute, ordinance, regulation, order, code, judgment, charge, writ, injunction, or
decree. 
 1.2.32. “NDA” shall mean the nondisclosure agreement between the Parties dated July 21, 2010.

 1.2.33. “Negotiation Period” shall have the meaning set forth in Section 4.2.2. 

1.2.34. “Other Equipment” shall have the meaning set forth in Section 7.2. 

1.2.35. “Party” shall mean Genomatica or T&L, as the case may be, and “Parties” shall mean
Genomatica and T&L. 

  
 4. 

 1.2.36. “Patent Rights” shall mean any patent application, certificate of
invention, application for certificate of invention, priority patent filing or patent (foreign or domestic), including any and all divisionals, continuation (in whole or in part), request for continued examination, reissues, reexaminations,
additions, substitution cases, confirmations, registrations, revalidations, revisions, renewals and extensions thereof. 

1.2.37. “Person” shall mean an individual or a corporation, partnership, limited liability company, trust, incorporated
or unincorporated association, joint venture, joint stock company, government (or an agency or political subdivision thereof) or other entity of any kind. 
 1.2.38. “Polymer-grade” shall refer to the quality of the bio-material meeting the specifications set forth on Schedule 1.2.38. 

1.2.39. “Potential Transaction” shall have the meaning set forth in Section 4.3. 

1.2.40. “Process Intellectual Property” shall mean all Intellectual Property relating to all or part of a Bioprocess,
including any components (including microorganisms) used in a Bioprocess, and/or the basic engineering package for the Demonstration Facility, which Intellectual Property is first conceived, reduced to practice and/or otherwise acquired or obtained
solely by a Party or jointly by the Parties in the course of and during the term of the Joint Development Program, including rights arising in the course of prosecution and maintenance of such Intellectual Property. For clarification, Process
Intellectual Property excludes all Background Intellectual Property. 
 1.2.41. “Representatives” shall mean,
with respect to any Person, the directors, officers, employees, agents, Affiliates, or other representatives of such specified Person, including, without limitation, financial advisors, consultants, and counsel. 

1.2.42. “Services Agreement” shall mean either or both of the Services Agreement (CP) and Services Agreement (DP).

 1.2.43. “Services Agreement (CP)” shall have the meaning set forth in Section 3.4. 

1.2.44. “Services Agreement (DP)” shall have the meaning set forth in Section 3.1(b). 

1.2.45. “Specified Equipment” shall have the meaning set forth in Section 7.2. 

1.2.46. “T&L Confidential Information” shall mean any Confidential Information of T&L. 

 

  
 5. 

 1.2.47. “T&L Intellectual Property” shall mean (a) all Background
Intellectual Property owned or licensed (with the right to grant licenses or sublicenses) by T&L, and (b) all JDA Intellectual Property owned by T&L. 
 1.2.48. “Term Sheet” shall have the meaning set forth in Section 3.4. 
 1.2.49. “Territory” shall mean the United States of America. 

1.2.50. “Third Party(ies)” shall mean any Person other than Genomatica and its Affiliates or T&L and its Affiliates.

 ARTICLE II 
 JOINT DEVELOPMENT PROGRAM OBJECTIVES 
 2.1. Objectives. The purpose
of the Parties’ relationship under this JDA is to (a) further develop Genomatica’s current Bioprocess at the T&L Decatur, Illinois demonstration plant, Building 119 and certain fermentation lab facilities located at Building 59
(the “Demonstration Facility”), to produce Bio-BDO from dextrose feedstocks sourced from a T&L corn wet-mill facility and (b) develop Genomatica’s current Bioprocess into a continuous or semi-continuous commercial
Bioprocess for producing Polymer-grade Bio-BDO from feedstocks from carbohydrate streams from corn grind mills (the “Commercial Process”) at a cash cost below that of BDO produced by other means, which cost is currently estimated at
$[...***...] per pound for all production costs including raw materials. The Parties also desire to discuss options to work together to commercialize in the Territory Bio-BDO produced using the Commercial Process and dextrose feedstocks at a
commercial manufacturing facility co-located with a T&L-owned corn wet-mill facility in the Territory (the “Commercial Facility”). The Joint Development Program will be conducted in two stages. 

2.1.1. Investigative Phase. The objective of the first stage of the Joint Development Program is to test potential commercially
viable microbial strains at small scale and identify process steps that have a high probability of being those used in the first commercial scale facility (the “Investigative Phase”). The principal tasks in the Investigative Phase
shall consist of those matters set forth in the Development Plan. 
 2.1.2. Demonstration Phase. The objective of the
second stage of the Joint Development Program is to demonstrate the ability to manufacture Polymer-grade Bio-BDO at the projected commercial scale in the 13,000 liter fermenter by the Bioprocess selected in the Investigative Phase (the
“Demonstration Phase”). The principal tasks in the Demonstration Phase shall consist of those matters set forth in the Development Plan. 

  

					
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 ARTICLE III 
 INVESTIGATIVE PHASE; DEMONSTRATION PHASE 
 3.1. Investigative Phase.

 (a) As soon as practicable following the Effective Date, the Parties will commence the Investigative Phase and
will conduct the Investigative Phase in accordance with the Investigative Phase Plan. The JDC will determine whether the technical key performance indexes for the Investigative Phase as set forth in the Development Plan (the “Development
KPIs”) have been satisfied. The Investigative Phase will end upon the date that the principal tasks in the Investigative Phase (and any other tasks reasonably determined by Genomatica) have been completed, whether or not the Development
KPIs have been satisfied. 
 (b) Concurrently with the execution of this JDA, T&L and Genomatica are entering
into a services agreement (the “Services Agreement (DP)”) for services to be provided by T&L during the Demonstration Phase. 
 (c) During the Investigative Phase, the JDC will jointly develop and approve a plan, based upon the draft plan included in the Development Plan, detailing the deliverables (including the Genomatica
deliverables and the T&L deliverables, as described in Section 3.3), the estimated timelines and a budget associated with [...***...] (the “Demonstration Plan”). Any amendments to the Demonstration Plan will be
subject to approval of the JDC. 
 (d) During the Investigative Phase, each of Genomatica and T&L will bear
50% of the costs and expenses in the categories set forth in the Development Plan incurred by either Party in the performance of the activities under the Development Plan, which costs and expenses do not exceed the budget as set forth in the
Development Plan by more than [...***...]% unless otherwise approved by the JDC. On a monthly basis, within [...***...] after the end of each month during the Investigative Phase, T&L will provide a written report to Genomatica
setting forth in reasonable detail such costs and expenses incurred by T&L for such month (together with the evidence supporting such costs and expenses). Within [...***...] after receipt of such report from T&L, Genomatica shall
provide T&L (i) a written reconciliation report, showing such costs and expenses incurred by each Party during such month and the amount payable by Genomatica to T&L (or if applicable, by T&L to Genomatica), and (ii) payment to
T&L (or an invoice for the amount payable to Genomatica, if applicable), so that each Party bears 50% of such costs and expenses as provided in this Section 3.1(d). 
 3.2. Demonstration Phase. 
 (a) Upon completion of the
Investigative Phase, Genomatica may elect to initiate the Demonstration Phase and commence activities under the 

  

					
		 	7.	  	***Confidential Treatment Requested

 
Demonstration Plan by providing written notice to T&L. During the Demonstration Phase, the responsibility of the Parties for costs and expenses will be as set forth in the Services Agreement
(DP). Without the approval of the JDC, neither Party will incur any capital expenditures in the performance of the Demonstration Phase except as expressly set forth in the Development Plan; provided that a Party may incur capital expenditures not
set forth in the Development Plan at its own expense, subject to reimbursement as may be set forth in the Commercialization Agreement if T&L and Genomatica enter into the Commercialization Agreement. 

(b) Genomatica will bear all expenses it incurs in connection with performance of the Demonstration Phase unless and until
T&L and Genomatica enter into a Commercialization Agreement, in which event T&L will reimburse Genomatica for expenses as set forth in the Commercialization Agreement. The JDC will determine whether the technical and commercial key
performance indexes for the Demonstration Phase as set forth in the Development Plan (the “Commercialization KPIs”) have been satisfied. The Demonstration Phase will continue until the date that the principal tasks in the
Demonstration Phase (and any other tasks reasonably determined by Genomatica) have been completed, whether or not the Commercialization KPIs have been satisfied. 
 3.3. Deliverables. 
 3.3.1. Genomatica Deliverables. 

(a) During the Investigative Phase, Genomatica will be responsible for (i) developing for the Demonstration Facility
[...***...], which will be subject to review by T&L through the JDC and will comply with safety and environmental standards required for activities conducted at the Demonstration Facility, and (ii) completing [...***...] the
Demonstration Facility, in each case subject to having sufficient data regarding the Demonstration Facility to enable such activities. 
 (b) During the Demonstration Phase, Genomatica will be responsible for developing a Commercial Process based upon Genomatica’s current Bioprocess, which is cost advantaged relative to petroleum BDO
plant costs, and which will be subject to review by T&L through the JDC and will comply with safety and environmental standards required for activities conducted at the Commercial Facility, subject to having sufficient data regarding the
Commercial Facility to enable such activities. 
 3.3.2. T&L Deliverables. 

(a) During the Investigative Phase, T&L will be responsible for developing [...***...]. 

  

					
		 	8.	  	***Confidential Treatment Requested

 [...***...]. 

(b) During the Demonstration Phase, T&L will be responsible for the following pursuant to the Services Agreement (DP):

 (i) providing dextrose; 

(ii) providing manufacturing expertise and experience to the Bio-BDO process; and 

(iii) providing product support services including analytical, QA, QC and product storage. 

In addition, during the Demonstration Phase, T&L will be responsible for [...***...] to Genomatica. 

3.3.3. Joint Deliverables. The Parties will be jointly responsible for the following deliverables under the Demonstration Plan:

 (a) jointly developing [...***...] that is acceptable to both Parties; and 

(b) coordinating any external communications regarding the Demonstration Plan. 

3.4. Discussion of Potential Commercialization Structure Options. During the Demonstration Phase, the Parties will discuss options
to work together to commercialize Bio-BDO in the Territory using the Commercial Process at the Commercial Facility and will negotiate in good faith an agreed term sheet that specifies the commercial structure (“Term Sheet”). Among
other possibilities for commercial structure, the Parties may form (a) a commercial joint venture to build and operate commercial manufacturing facilities, which joint venture may be structured as [...***...] pursuant to a corn processing
agreement in substantially the form attached hereto as Schedule 3.4 (the “Corn Processing Agreement”). The Services Agreement (CP) would become effective at such time as Genomatica provides T&L with written notice
pursuant to Section 4.1 that Genomatica is electing to initiate the Commercialization Phase; provided, that T&L shall not be required to enter into the Services Agreement (CP) if Genomatica has not undertaken significant commercial
activities in connection with the Commercialization Phase within [...***...] 

  

					
		 	9.	  	***Confidential Treatment Requested

 [...***...] after the Effective Date. The Corn Processing Agreement would become effective at such
time as Genomatica or any joint venture or other Person in which Genomatica has an economic interest determines to enter into an arrangement for the purchase of dextrose for use in the commercialization of Bio-BDO produced using the Commercial
Process in the first commercial facility in the Territory. 
 ARTICLE IV 

COMMERCIALIZATION PHASE 
 4.1. Election to Participate in Commercialization Phase. Upon completion of the Demonstration Phase, provided that the Bio-BDO produced in the Demonstration Phase meets minimum standards of quality
applicable to petroleum-based BDO, which specifications are described on Schedule 1.2.38, Genomatica may elect to initiate the Commercialization Phase by providing written notice to T&L. Genomatica will bear all expenses it incurs in
the Commercialization Phase unless and until Genomatica and T&L enter into a Commercialization Agreement, in which event T&L will reimburse Genomatica for Genomatica’s expenses as set forth in the Commercialization Agreement. T&L
shall provide Genomatica with written notice of whether or not T&L is electing to participate in the Commercialization Phase no later than the date that is the later of [...***...] after the Effective Date and [...***...], together
with the details associated therewith (the “Election Period”). If T&L does not provide written notice to Genomatica by the expiration of the Election Period, T&L shall be deemed to have elected not to participate in the
Commercialization Phase. 
 4.2. Negotiation of Commercialization Agreement. 

4.2.1. In the event T&L elects to participate in the Commercialization Phase in accordance with Section 4.1, the Parties will
negotiate in good faith the definitive agreements for the commercialization of Bio-BDO produced using the Commercial Process in the Territory (any such definitive agreement, a “Commercialization Agreement”), which agreements will
incorporate the terms reflected in the Term Sheet and will be subject to the approval of each of the Parties in its sole discretion. The Commercialization Agreement shall provide that T&L will, upon execution, reimburse Genomatica for
(a) 50% of the costs and expenses incurred by Genomatica in the performance of the Demonstration Phase, (b) 50% of any capital expenditures not set forth in the Development Plan and not approved by the JDC that were made by Genomatica in
the performance of the Demonstration Phase, and (c) 50% of the costs and expenses incurred by Genomatica in the performance of the Commercialization Phase prior to the effective date of the Commercialization Agreement (or such lesser percentage
of such costs and expenses for the Commercialization Phase incurred by Genomatica equal to the ownership percentage of T&L in the commercial venture as reflected in the Commercialization Agreement). 

  

					
		 	10.	  	***Confidential Treatment Requested

 4.2.2. If the Parties do not execute a Commercialization Agreement within the 90-day period
immediately following the written notice from T&L of its election to participate in the Commercialization Phase in accordance with Section 4.1, or such longer period agreed in writing by the Parties (the “Negotiation
Period”), then neither Party will have any further obligation to the other Party to negotiate or enter into a Commercialization Agreement; provided, however, that [...***...]. Prior to T&L’s election and thereafter if either
T&L does not elect to participate in the Commercialization Phase or the Parties do not enter into a Commercialization Agreement during the Negotiation Period, the Services Agreement (CP) will be effective in accordance with its terms.

 4.3. Exclusivity Period. During the period from the delivery of written notice from T&L to Genomatica of
T&L’s election to participate in the Commercialization Phase in accordance with Section 4.1 until the earlier to occur of (a) [...***...] and (b) [...***...] (“Exclusivity Period”), Genomatica
will negotiate exclusively with T&L in good faith with respect to an agreement for the commercialization of Bio-BDO produced using the Commercial Process in the Territory (the “Potential Transaction”). During the Exclusivity
Period, Genomatica agrees that it will not, and will not permit any of its Representatives on its behalf, to (i) [...***...] with a Third Party, or (ii) [...***...] with a Third Party; provided, that Genomatica shall have the
right to [...***...]. In addition, during the period from the Effective Date until the end of the Exclusivity Period (or earlier upon expiration of the Election Period if T&L does not elect to participate in the Commercialization Phase in
accordance with Section 4.1), Genomatica agrees that it will not (A) approve, endorse or recommend any Potential Transaction with a Third Party or (B) enter into any letter of intent or similar document or any contract contemplating
or otherwise relating to any Potential Transaction with a Third Party; provided that nothing shall prevent Genomatica from entering into nondisclosure agreements relating to discussions that Genomatica may have prior to the end of the Exclusivity
Period with respect to a Potential Transaction or with off take companies as contemplated by this Section 4.3. 

  

					
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 4.4. Supply of Dextrose. If Genomatica or any joint venture or other Person in which
Genomatica has an economic interest determines to enter into an arrangement for the purchase of dextrose for use in the commercialization of Bio-BDO produced using the Commercial Process in the first commercial facility in the Territory, T&L
shall supply such dextrose to Genomatica or such joint venture or other Person pursuant to the Corn Processing Agreement for a period of five (5) years after the commissioning of the Commercial Facility related thereto, regardless of whether or not
T&L is participating with Genomatica in a joint venture with respect thereto. 
 ARTICLE V 

GOVERNANCE OF THE JOINT DEVELOPMENT PROGRAM 
 5.1. Formation of JDC. Promptly following the Effective Date, the Parties shall form the JDC, and each Party will appoint two of its employees to serve on the JDC. The purpose of the JDC is to
oversee, guide, and monitor the conduct of the Joint Development Program under the terms of this JDA. To ensure the success of the Joint Development Program, the JDC will meet regularly and at least quarterly to review the progress towards the
objectives of the Joint Development Program. Such meetings may be held in person, or by any means of telecommunications or video conference, as the JDC members deem necessary or appropriate. The JDC will keep minutes of its meetings, including at a
minimum who is in attendance, the subject matter discussed or considered, and any action taken. Decisions of the JDC will be made by unanimous approval, with the representatives of Genomatica collectively having one vote and the representatives of
T&L collectively having one vote. If the JDC is unable to reach agreement on any matter properly before it, then either Party may, by written notice to the other Party, have such matter referred for resolution pursuant to Section 14.14.

 5.2. Responsibilities of JDC. The JDC shall have the following responsibilities and authority: 

 

	 	(a)	to provide a means of communication between the Parties regarding the Joint Development Program; 

 

	 	(b)	subject to and within the parameters of the Development Plan, to monitor and oversee the implementation of the Development Plan; 

 

	 	(c)	to review and approve any amendments or modifications to the Development Plan; and 

 

	 	(d)	such other responsibilities as expressly assigned to the JDC under this JDA or by written agreement of the Parties. 

5.3. Reservation of Rights. Matters outside the scope of the Joint Development Program and internal to each Party are not under
the purview of the JDC. Such matters include but are not limited to internal personnel policies and programs, budgeting, finance, commercial and marketing strategies, and business decisions. 

  

					
		 	12.	  	

 
However, the Parties agree to communicate with each other promptly on those matters which, while outside the scope of the Joint Development Program, nevertheless may reasonably be expected to
affect the Joint Development Program. 
 5.4. Independent Contractors. Each party is an independent contractor and shall
retain complete control and responsibility for its own operations and employees. Nothing in this JDA shall be construed to constitute either Party as a partner, agent or representative of the other Party. Neither Party shall have the right or
authority to assume or create any obligation on behalf of or in the name of the other, or to bind the other in any manner whatsoever. 
 ARTICLE VI 
 ADDITIONAL OBLIGATIONS OF T&L 

6.1. Supply of Storage Equipment and Instrumentation. Subject to payment under the Services Agreement (DP), during the
Demonstration Phase and in accordance with the Demonstration Plan, T&L shall supply all equipment and instrumentation for the storing of ingredients and supplies, excluding dextrose, for the storing of crude and purified Bio-BDO, and for the
storing and disposal of waste materials generated by the processes, provided that such storage and disposal are permissible under current T&L permits. The JDC will discuss the scope of storage and disposal of waste materials permissible under
current T&L permits and whether any waste materials resulting from the Demonstration Phase would be outside the scope of such permits and, if so, alternatives for addressing storage and disposal of such waste materials. T&L will not be
required to undertake storage and disposal of waste materials that are not permissible under current T&L permits, unless Genomatica agrees to pay for any increased costs of such storage and disposal, subject to reimbursement as may be set forth
in the Commercialization Agreement if T&L and Genomatica enter into the Commercialization Agreement. T&L shall own all right, title and interest in and to any such equipment or instrumentation supplied by T&L. 

6.2. Installation of Equipment and Instrumentation. Subject to payment under the Services Agreement (DP), during the Demonstration
Phase and in accordance with the Development Plan, T&L shall install all equipment and instrumentation (including any Genomatica-supplied equipment or instrumentation) at the Facilities. The equipment and instrumentation, together with the
Facilities, shall be accessible, upon reasonable prior notice, to Genomatica employees assigned to support the Joint Development Program. 
 6.3. Services. Subject to payment under the Services Agreement (DP), during the Demonstration Phase and in accordance with the Development Plan, T&L shall supply (i) technical and
engineering services for the Facilities and (ii) employees to operate the Facilities. 
 6.4. Access to Information and
Data. T&L shall provide Genomatica reasonable access to all Confidential Information, technical information, and data used during and data generated from the startup and operation of the Facilities. 

  
 13.

 6.5. Provision of T&L Code of Conduct. T&L has provided to Genomatica
T&L’s Code of Conduct in effect as of the Effective Date. 
 ARTICLE VII 

ADDITIONAL OBLIGATIONS OF GENOMATICA 
 7.1. Supply of Materials. During the Demonstration Phase and in accordance with the Development Plan, Genomatica shall select and supply [...***...] pursuant to this JDA. 

7.2. Supply of Equipment and Instrumentation. Subject to reimbursement under the Commercialization Agreement (if applicable),
during the Demonstration Phase and in accordance with the Development Plan, Genomatica shall supply all equipment and instrumentation required to be supplied by Genomatica under the Development Plan. The Genomatica-supplied equipment and
instrumentation shall be installed at the Demonstration Facility. Genomatica shall own all right, title and interest in and to the [...***...] supplied by Genomatica (the “Specified Equipment”), and T&L shall own all
right, title and interest in and to [...***...] (the “Other Equipment”). Maintenance and repair of the Specified Equipment and the Other Equipment shall be provided for in the Services Agreement (DP). If this JDA terminates
and the Parties do not enter into a Commercialization Agreement, T&L will have thirty (30) days after the termination of this JDA to determine whether T&L desires to retain ownership of any Other Equipment. With respect to any Other
Equipment that T&L elects to retain ownership of, Genomatica shall be entitled to a credit equal to [...***...]% of the supply cost of such Other Equipment against any goods and/or services provided by T&L to Genomatica under any
Services Agreement and/or the Corn Processing Agreement. Genomatica, at its sole cost and expense (including repair costs), shall remove from the Demonstration Facility within two months after the termination of this JDA any Specified Equipment and
any Other Equipment which T&L elects not to retain ownership of, with Genomatica acquiring all of T&L’s right, title and interest in and to any such Other Equipment upon removal and payment in accordance with the foregoing. In the event
that Genomatica does not remove any such Specified Equipment or Other Equipment within two months after the termination of this JDA, T&L shall have the right to remove such equipment and Genomatica shall promptly reimburse T&L for the cost
of removal thereof. 
 7.3. Availability of Technical Employees. Genomatica shall make available such technical employees
at the Facilities reasonably required by T&L to assist in the development of the Bioprocess as provided in the Development Plan. Genomatica shall cause its employees made available pursuant to this Section 7.3 to comply with T&L’s
safety, health, and environmental policies and procedures and ethical guidelines while such employees are at the Facilities. 

7.4. Compliance with T&L Code of Conduct. Genomatica acknowledges that it has read T&L’s Code of Conduct provided to
Genomatica by T&L and that 

  

					
		 	14.	  	***Confidential Treatment Requested

 
Genomatica shall comply with the standards, expectations and commitments from such Code of Conduct in connection with the performance of its obligations under this JDA. 

7.5. Conduct of Test Market Evaluations. Genomatica shall conduct test market evaluations of the Bio-BDO produced by the
Facilities and conduct end-use product testing [...***...] (notwithstanding anything to the contrary set forth herein). Genomatica will share the results of all such testing with T&L. Genomatica will share with T&L all volume demand
forecasts for Bio-BDO (by application). Such results and forecasts shall be Genomatica Confidential Information subject to Article X of this JDA. 
 7.6. Licenses. Subject to reimbursement under the Commercialization Agreement (if applicable), Genomatica will be responsible for obtaining any licenses to Third Party Intellectual Property for use
in the production of Bio-BDO under this JDA and the Commercialization Agreement, as applicable. 
 ARTICLE VIII

 INTELLECTUAL PROPERTY 
 8.1. Background Intellectual Property. Each Party acknowledges and agrees that, as between the Parties, each Party is and shall remain the sole and exclusive owner of all right, title, and interest
in and to its Background Intellectual Property, and that this JDA does not affect such ownership. Each Party acknowledges that it acquires no rights under this JDA to the other Party’s Background Intellectual Property other than the limited
rights specifically granted in this JDA. 
 8.2. Process Intellectual Property. All Process Intellectual Property will be
owned by Genomatica. The Parties shall use commercially reasonable efforts to promptly disclose and jointly identify all Process Intellectual Property during the term of this JDA. T&L hereby irrevocably transfers, conveys and assigns to
Genomatica all of its right, title, and interest in the Process Intellectual Property. T&L shall execute such documents, render such assistance, and take such other action as Genomatica may reasonably request, at Genomatica’s expense, to
apply for, register, perfect, confirm, and protect Genomatica’s ownership rights in the Process Intellectual Property, and Genomatica shall have the exclusive right to apply for and register any patents and other proprietary protections with
respect to the Process Intellectual Property. To the extent that a Party has the right to practice and use the Process Intellectual Property outside the course of the Joint Development Program as provided in this JDA, such Party shall have the
exclusive right to apply for or register any patents and other Intellectual Property claiming or covering any inventions arising from such permitted practice or use of the Process Intellectual Property that are first conceived or reduced to practice
solely by employees and/ or consultants of that Party outside the course of the Joint Development Program. 
 8.3. JDA
Intellectual Property. JDA Intellectual Property first conceived or reduced to practice solely by employees and/ or consultants of a Party shall be owned solely by such Party, and JDA Intellectual Property first conceived or reduced to practice

  

					
		 	15.	  	***Confidential Treatment Requested

 
jointly by employees and/or consultants of both Parties shall be owned jointly by the Parties. A Party shall have the exclusive right to apply for or register any patents and other proprietary
protections with respect to the JDA Intellectual Property solely owned by such Party, including, for example, improvements, modifications, or uses of existing technology in different areas. The Parties through the JDC shall agree which Party shall
apply for and register any patents and other proprietary protections with respect to the JDA Intellectual Property jointly owned by the Parties, and shall cooperate in such activities, including sharing copies of filings with adequate time for
review and comment by the other Party, and assembling inventorship information and data for filing such patent applications. Each Party shall have the right to use and practice, and grant licenses to use and practice, all jointly owned JDA
Intellectual Property, without the consent of or any duty of accounting to the other Party provided that [...***...]. To the extent that a Party has the right to practice and use the JDA Intellectual Property outside the course of the Joint
Development Program as provided in this JDA, such Party shall have the exclusive right to apply for or register any patents and other Intellectual Property claiming or covering any inventions arising from such permitted practice or use of the JDA
Intellectual Property that are first conceived or reduced to practice solely by employees and/ or consultants of that Party outside the course of the Joint Development Program. 

8.4. Expenses for Jointly Owned JDA Intellectual Property. [...***...] will bear all costs and expenses associated with the
preparation, filing, prosecution, and maintenance of any patent applications or patents for [...***...] unless and until Genomatica and T&L enter into a Commercialization Agreement, in which event [...***...] as reflected in the
Commercialization Agreement). No Party shall withdraw support for such jointly owned patent applications or discontinue maintenance of such jointly owned patents without first giving the other Party a meaningful opportunity to assume expenses
thereof. 
 8.5. No Implied Licenses. No license or right is granted by implication or otherwise with respect to any
patent application or patent except as may be specifically set forth in this JDA. T&L and Genomatica will promptly notify the other in writing if such Party (a) becomes aware of any Intellectual Property of a Third Party that would be
infringed by the activities under the Joint Development Program, (b) receives a written claim or notice of infringement of any Intellectual Property of a Third Party related to the activities under the Joint Development Program or (c) is
sued for infringement of any Intellectual Property of a Third Party as a result of the activities under the Joint Development Program. 

  

					
		 	16.	  	***Confidential Treatment Requested

 ARTICLE IX 
 GRANT OF RIGHTS 
 9.1. Limited License for Joint Development
Program. Subject to the terms and conditions of this JDA, Genomatica hereby grants to T&L a non-exclusive, non-sublicensable (except to T&L’s Affiliates), royalty-free license to use Genomatica Intellectual Property directly
relevant to the Joint Development Program within the Territory solely for purposes of performing T&L’s obligations under the Joint Development Program during the term of this JDA. Subject to the terms and conditions of this JDA, T&L
hereby grants to Genomatica a non-exclusive, non-sublicensable, (except to Genomatica’s Affiliates), royalty-free license to use T&L Intellectual Property directly relevant to the Joint Development Program within the Territory solely for
purposes of performing Genomatica’s obligations under the Joint Development Program during the term of this JDA. If a Party grants a sublicense of the license under this Section 9.1 to any of its Affiliates, such Party shall cause its
Affiliates to comply with all obligations of such Party hereunder, including, without limitation, Articles VIII and X; provided that such Party shall at all times be fully responsible for the performance of such Affiliate. 

9.2. Limited License for Other Activities. Subject to the terms and conditions of this JDA, Genomatica hereby grants to T&L a
non-exclusive, royalty-free license to practice Process Intellectual Property and JDA Intellectual Property for the development, production, sale and distribution of materials or products other than BDO. T&L may grant sublicenses under such
license to any Third Party with whom T&L or its Affiliate has a partnership, agreement or arrangement related to the development, production, sale or distribution of materials or products other than BDO; provided, that T&L may not grant
sublicenses under such license to any Third Party for the production of materials or products listed on Schedule 9.2 at any time prior to the date that is [...***...] after the Effective Date as listed on Schedule 9.2.
If T&L grants a sublicense of the license under this Section 9.2, T&L shall cause its sublicensees to be bound by the obligations of T&L arising under this Article IX and Article X; provided that T&L shall be liable for any
breach of such obligations by such sublicensee. Subject to the terms and conditions of this JDA, T&L hereby grants to Genomatica a non-exclusive, sublicensable, royalty-free license to practice JDA Intellectual Property for the development,
production, sale and distribution of BDO and the development, production, sale and distribution of materials or products other than BDO. If Genomatica grants a sublicense of the license under this Section 9.2, Genomatica shall cause its
sublicensees to be bound by the obligations of Genomatica arising under this Article IX and Article X; provided that Genomatica shall be liable for any breach of such obligations by such sublicensee. 

9.3. Reservation of Rights to Intellectual Property. T&L reserves all rights under the T&L Intellectual Property, subject
only to the license granted to Genomatica in Sections 9.1 and 9.2, and Genomatica reserves all rights under the Genomatica Intellectual Property, subject only to the licenses granted to T&L in Sections 9.1 and 9.2. Notwithstanding
anything to the contrary in this JDA, the Parties acknowledge and agree 

  

					
		 	17.	  	***Confidential Treatment Requested

 
that general knowledge about operation of the Facilities learned or observed in the course of the Joint Development Agreement may be used by either Party. 

9.4. Mutual Agreements. T&L agrees not to practice the Genomatica Intellectual Property and the JDA Intellectual Property
developed jointly by the Parties, and Genomatica agrees not to practice the T&L Intellectual Property and the JDA Intellectual Property developed jointly by the Parties, in each case except as expressly permitted in this JDA or other written
agreement between the Parties. 
 9.5. No Use of Names. Except as otherwise provided herein, no right, express or
implied, is granted by this JDA to use in any manner the name “T&L” or “Genomatica” or any other trademark, service mark, or trade name of the other Party in connection with the performance of this JDA. 

ARTICLE X 

CONFIDENTIAL INFORMATION 
 10.1. Confidentiality. Each Party (in such capacity, the “receiving Party”) agrees to maintain the confidentiality of, and not disclose to any other Person, all Confidential Information
of the other Party (in such capacity, the “disclosing Party”) and not to use the Confidential Information of the other Party except for the purposes of this JDA or pursuant to the terms of a Commercialization Agreement, in each case for
[...***...] years from the Effective Date of this JDA. The obligation of confidentiality, nondisclosure and nonuse shall not apply to Confidential Information which: 

 

	 	(a)	is or becomes public through no fault of the receiving Party; 

  

	 	(b)	is known by the receiving Party at the time of disclosure as shown by prior written records; 

 

	 	(c)	is disclosed to the receiving Party by a Third Party entitled to disclose it without obligation of confidentiality, or 

 

	 	(d)	is independently developed by the receiving Party. 

 10.2. Permitted Disclosures. Each Party may disclose Confidential Information belonging to the other Party: 
  

	 	(a)	to its own employees or consultants who are subject to binding obligations concerning confidential information and inventions, to the extent such disclosure is
reasonably necessary in connection with the activities contemplated by this JDA, provided that the disclosing Party shall be responsible for any breach thereof by its own employees or consultants; 

 

	 	(b)	to the extent such disclosure is reasonably necessary for filing or prosecuting patents as expressly permitted by Article VIII; or 

	

  

					
		 	18.	  	***Confidential Treatment Requested

 (c) to the extent such disclosure is reasonably necessary for prosecuting or
defending litigation or complying with applicable laws, rules or governmental regulations, provided that in the event a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to this clause (c), it shall,
except where impracticable or not permitted by Law, give reasonable advance notice to the other Party of such disclosure and use commercially reasonable efforts, at the cost of the other Party, to secure confidential treatment of such information.

 10.3. Permitted Disclosure of Material Terms of this JDA. A Party shall have the right to disclose the material terms
of this JDA (a) to any Person retained by such Party to perform legal, accounting, engineering or similar services and who have a need to know such terms in order to provide such services and (b) to Third Parties in connection with due
diligence or similar investigations by such Third Parties, provided that any such Person or Third Party is bound to confidentiality obligations consistent in all material respects with the terms of this Article X. 

10.4. Publicity. In any event, each Party agrees to take all reasonable action to avoid disclosure of the other Party’s
Confidential Information hereunder. Promptly following the Effective Date, the Parties will coordinate issuing a press release concerning this JDA (which may be a joint press release or separate press releases by each Party), subject to mutual
agreement of the Parties on the content of such press release. If either Party desires to, or is required by Law or stock exchange requirements to, make a public announcement concerning this JDA or the subject matter hereof after such initial press
release, such Party shall give reasonable prior advance notice of the proposed text of such announcement to the other Party for its prior review and comment. 
 10.5. JDA Terms Are Confidential Information of Both Parties. Except for public statements agreed to by the Parties or for disclosures that are in the reasonable judgment of a Party required by Law
or stock exchange listing requirements, the Parties agree that the existence, material terms, and the subject matter of this JDA shall be considered Confidential Information of both Parties. 

10.6. Equitable Remedies. Each Party acknowledges and agrees that the other Party’s remedies at law for breach or threatened
breach of any of the provisions of this Article X would be inadequate and, in recognition of that fact, in the event of any such breach or threatened breach, it is agreed that, in addition to other remedies to which it may be entitled, the
other Party will be entitled to equitable relief in the form of specific performance, temporary restraining order, temporary or permanent injunction without the necessity of posting bond, or any other equitable remedy which may then be available;
provided, that nothing herein contained will be construed as prohibiting the non-breaching Party from pursuing any other remedies available to it for such breach or threatened breach, including recovery of damages from such breaching Party.

  
 19.

 ARTICLE XI 
 REPRESENTATIONS AND WARRANTIES 
 11.1. Representations and Warranties of
Genomatica. Genomatica represents and warrants to T&L as of the Effective Date that: 
 (a) Genomatica is
a corporation, duly incorporated, validly existing and in good standing under the laws of the State of Delaware. Genomatica has all requisite power and authority to carry on its business and to own and use the assets and properties owned and used by
it. 
 (b) Genomatica has all requisite power and authority to execute and deliver this JDA and to perform its
obligations hereunder. The execution and delivery of this JDA by Genomatica and the performance by Genomatica of its obligations hereunder have been duly and validly authorized by all necessary action on the part of Genomatica. This JDA has been
duly and validly executed and delivered by Genomatica and, assuming the due authorization, execution and delivery by T&L, constitutes a valid and binding obligation of Genomatica enforceable against Genomatica in accordance with its terms.

 (c) The execution and delivery of this JDA by Genomatica and the performance by Genomatica of its obligations
hereunder, does not and will not, as the case may be, (i) conflict with or violate any provision of the Certificate of Incorporation or the Bylaws of Genomatica, (ii) conflict with, result in a breach of, constitute (with or without due
notice or lapse of time or both) a default under, result in the acceleration of, create in any party the right to accelerate, terminate, modify or cancel, or require any notice, consent or waiver under, any contract, agreement or arrangement
(written or oral), franchise or permit to which Genomatica is a party or by which Genomatica is bound, (iii) result in the imposition of any lien, claim, charge or encumbrance upon any Genomatica Intellectual Property, or (iv) violate any
Law applicable to Genomatica. 
 (d) There is no action, suit, proceeding, claim, or investigation pending or
threatened against Genomatica, in any court or by or before any governmental authority, or before any arbitrator of any kind, which, if adversely determined, would restrict the ability of Genomatica to perform its obligations hereunder. Genomatica
knows of no basis for any such action, suit, claim, investigation, or proceeding. 
 (e) Genomatica is the
exclusive owner of the Background Intellectual Property included in the Genomatica Intellectual Property, and it has the right to grant T&L the limited license under Section 9.1 without conflict with the rights of any Third Party, or has
secured all necessary and appropriate consents to license the same. 

  
 20.

 (f) The Background Intellectual Property included in the Genomatica
Intellectual Property is not subject to any claims, encumbrances, liens, licenses, judgments and/or security interests that could reasonably be expected to have an adverse effect on the right to practice such Background Intellectual Property in the
Bio-BDO Field, and none of the Background Intellectual Property included in the Genomatica Intellectual Property is the current subject of any litigation, interference or opposition proceeding. 

(g) Genomatica is unaware of any publications or activities (including, without limitation, patents, articles, and public
uses or sales) by it or others, which could reasonably be expected to invalidate any claim(s) of any patent or patent application within the Background Intellectual Property included in the Genomatica Intellectual Property. 

(h) Genomatica is not aware of any valid Third Party Intellectual Property that could reasonably be expected to be
infringed or asserted to be infringed by practice of the Background Intellectual Property included in the Genomatica Intellectual Property in the performance of the Joint Development Program pursuant to this JDA. 

(i) Genomatica has and will continue to have the legal power to extend the rights granted to T&L in this JDA with
respect to Process Intellectual Property and JDA Intellectual Property owned by Genomatica, and it has not made and will not make any commitments to others inconsistent with or in derogation of such rights. 

(j) Genomatica has, and will through the term of this JDA, cause its employees who work on the Joint Development Program
to disclose to it inventions within the scope of JDA Intellectual Property or Process Intellectual Property and to assign to it rights in such inventions, it being understood that if due care and diligence are used, any inadvertent failure to comply
with this Section 11.1(j) will not constitute a breach of this JDA. 
 11.2. Representations and Warranties of
T&L. T&L represents and warrants to Genomatica as of the Effective Date that: 
 (a) T&L is a
corporation validly existing and in good standing under the laws of the State of Delaware. T&L has all requisite power and authority to carry on its business and to own and use the assets and properties owned and used by it. 

(b) T&L has all requisite power and authority to execute and deliver this JDA and to perform its obligations
hereunder. The execution and delivery of this JDA by T&L and the performance by T&L of its obligations hereunder have been duly and validly authorized by all necessary action on the part of T&L. This JDA has been duly and validly
executed and delivered by T&L and, assuming the 

  
 21.

 
due authorization, execution and delivery by Genomatica, constitutes a valid and binding obligation of T&L enforceable against T&L in accordance with its terms. 

(c) The execution and delivery of this JDA by T&L and the performance by T&L of its obligations hereunder, does
not and will not, as the case may be, (i) conflict with or violate any provision of the Certificate of Incorporation or By-Laws of T&L, (ii) conflict with, result in a breach of, constitute (with or without due notice or lapse of time
or both) a default under, result in the acceleration of, create in any party the right to accelerate, terminate, modify or cancel, or require any notice, consent or waiver under, any contract, agreement or arrangement (written or oral), franchise or
permit to which T&L is a party or by which T&L is bound, (iii) result in the imposition of any lien, claim, charge or encumbrance upon any T&L Intellectual Property, or (iv) violate any Law applicable to T&L. 

(d) There is no action, suit, proceeding, or material claim or investigation pending or threatened against T&L, in any
court or by or before any governmental authority, or before any arbitrator of any kind, which, if adversely determined, would restrict T&L’s ability to perform its obligations hereunder. T&L knows of no basis for any such action, suit,
claim, investigation, or proceeding. 
 (e) T&L is the exclusive owner of the Background Intellectual
Property included in the T&L Intellectual Property, and it has the right to grant Genomatica the limited license under Section 9.1 without conflict with the rights of any Third Party, or has secured all necessary and appropriate consents to
license the same. 
 (f) The Background Intellectual Property included in the T&L Intellectual Property is
not subject to any claims, encumbrances, liens, licenses, judgments and/or security interests that could reasonably be expected to have an adverse effect on the right to practice such Background Intellectual Property in the Bio-BDO Field, and none
of the Background Intellectual Property included in the T&L Intellectual Property is the current subject of any litigation, interference or opposition proceeding. 

(g) T&L is unaware of any publications or activities (including, without limitation, patents, articles, and public
uses or sales) by it or others, which could reasonably be expected to invalidate any claim(s) of any patent or patent application within the Background Intellectual Property included in the T&L Intellectual Property. 

(h) T&L is not aware of any valid Third Party Intellectual Property that could reasonably be expected to be infringed
or asserted to be infringed by practice of the Background Intellectual Property included in the Genomatica Intellectual Property in the performance of the Joint Development Program pursuant to this JDA. 

	

  
 22.

 (i) T&L has and will continue to have the legal power to extend the
rights granted to Genomatica in this JDA with respect to Process Intellectual Property and JDA Intellectual Property owned by T&L, and it has not made and will not make any commitments to others inconsistent with or in derogation of such rights.

 (j) T&L has, and will through the term of this JDA, cause its employees who work on the Joint Development
Program to disclose to it inventions within the scope of JDA Intellectual Property or Process Intellectual Property and to assign to it rights in such inventions, it being understood that if due care and diligence are used, any inadvertent failure
to comply with this Section 11.2(j) will not constitute a breach of this JDA. 
 11.3. Notice of Developments. The
Parties will give prompt written notice to each other of (a) any event or development causing a breach of any of their respective representations and warranties contained in this JDA, (b) any failure to comply with or satisfy any covenant
or agreement to be complied with by such Party hereunder and (c) any event or development that, individually or in the aggregate, could reasonably be expected to result in a breach of any of their respective representations and warranties
contained in this JDA or the failure to comply with or satisfy any covenant or agreement to be complied with by such Party hereunder. No disclosure by any Party pursuant to this Section 11.3, however, shall be deemed to prevent or cure any
misrepresentation, breach of warranty or breach of covenant. During the term of this JDA, no Party shall take any action or agree to take any action, either orally or in writing, that could reasonably be expected to result in a breach of any of
their respective representations and warranties contained in this JDA or any failure to comply with or satisfy any covenant or agreement to be complied with by such Party hereunder. 

11.4. DISCLAIMER OF WARRANTIES. Except as specifically provided in this Article XI, each Party disclaims all warranties of
any kind, express or implied, to the fullest extent permitted by Law, including but not limited to the implied warranties of merchantability, fitness for particular purpose and noninfringement. NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY WITH
REGARD TO THE SUCCESS OF THE JOINT DEVELOPMENT PROGRAM OR THE USEFULNESS OF ANY BACKGROUND INTELLECTUAL PROPERTY, PROCESS INTELLECTUAL PROPERTY OR JDA INTELLECTUAL PROPERTY. 
 ARTICLE XII 
 INDEMNIFICATION 

12.1. Indemnification by Genomatica. Genomatica shall indemnify, defend, and hold harmless T&L and its Representatives from
and against any and all damages, losses, liabilities, judgments, awards, costs, and expenses of any nature whatsoever, including reasonable attorneys’ fees and court costs (collectively, “Damages”), incurred by any of them as a
result of (a) any Third Party claims, actions, suits or proceedings arising from any breach of any representation, warranty, covenant or agreement of Genomatica herein 

  
 23.

 
or (b) any Third Party claims that the practice of the Background Intellectual Property included in the Genomatica Intellectual Property in the performance of the Joint Development Program
pursuant to this JDA infringes Intellectual Property of such Third Party. 
 12.2. Indemnification by T&L. T&L
shall indemnify, defend, and hold harmless Genomatica and its Representatives from and against any and all Damages incurred by any of them as a result of (a) any Third Party claims, actions, suits or proceedings arising from any breach of any
representation, warranty, covenant or agreement of T&L herein or (b) any Third Party claims that the practice of the Background Intellectual Property included in the T&L Intellectual Property in the performance of the Joint Development
Program pursuant to this JDA infringes Intellectual Property of such Third Party. 
 12.3. Control of Defense. Except as
specifically provided in this section, any Person entitled to indemnification under this Article XII shall give written notice to the indemnifying Party of any claims that may be subject to indemnification, promptly after learning of such
claim, and the indemnifying Party shall assume the defense of such claims with counsel reasonably satisfactory to the indemnified party. If such defense is assumed by the indemnifying Party with counsel so selected, the indemnifying Party will not
be subject to any liability for any settlement of such claims made by the indemnified party without its consent (but such consent will not be unreasonably withheld or delayed), and will not be obligated to pay the fees and expenses of any separate
counsel retained by the indemnified party with respect to such claims. 
 12.4. Remedies. No remedy set forth in this JDA
is intended to be exclusive of any other remedy. Each remedy shall be in addition to every other remedy provided hereunder, or now or hereafter existing at law, in equity, by statute, or otherwise. 

ARTICLE XIII 
 TERM AND TERMINATION 
 13.1. Termination by the Parties. This JDA
may be terminated: 
 (a) by mutual written consent of T&L and Genomatica; 

(b) by Genomatica in the event T&L has breached in any material respect any representation, warranty, covenant or
agreement of T&L contained in this JDA, Genomatica has notified T&L of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach; 

(c) by T&L in the event Genomatica has breached in any material respect any representation, warranty, covenant or
agreement of Genomatica contained in this JDA, T&L has notified Genomatica of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach; 

  
 24.

 (d) by T&L in the event Genomatica has not notified T&L in writing
by March 15, 2012 that Genomatica is electing to proceed to the Demonstration Phase; or 
 (e) by T&L in
the event Genomatica has not notified T&L in writing by September 15, 2013 that Genomatica is electing to proceed to the Commercialization Phase. 
 Any termination of this JDA pursuant to Section 13.1 shall be effective upon the delivery of written notice of the terminating Party to the other Party. 

13.2. Automatic Termination. This JDA shall automatically terminate, unless the Parties agree otherwise, upon: 

(a) the date that Genomatica provides T&L with written notice that Genomatica is electing not to proceed to either the
Demonstration Phase or the Commercialization Phase; 
 (b) the date that T&L provides Genomatica with written
notice that T&L is electing not to proceed to the Commercialization Phase; 
 (c) the expiration of the
Election Period if T&L does not provide Genomatica with written notice prior to the end of the Election Period that T&L is electing to participate in the Commercialization Phase; 

(d) the expiration of the Negotiation Period if the Parties have not entered into a Commercialization Agreement during the
Negotiation Period; 
 (e) the date that the Services Agreement (DP) terminates; or 

(f) the date on which the Parties enter into a Commercialization Agreement. 

13.3. Effect of Termination. Upon termination of this JDA pursuant to this Article XIII, all rights and obligations of the
Parties under this JDA shall terminate, except as provided in this Section 13.3. Termination of this JDA shall not relieve or release either Party of any right or obligation which, at the time of such termination, has already accrued to such
Party or which is attributable to a period prior to such termination, nor will any expiration or termination of this JDA preclude either Party from pursuing all rights and remedies it may have under this JDA, at law or in equity, with respect to
breach of this JDA. The provisions set forth in Sections 4.2.2, 7.2, 9.2, 9.3, 9.4, 9.5, 11.4 and 13.3 and Articles I, VIII, X, XII and XIV shall remain in full force and effect and survive any termination of this JDA. The provisions set
forth in Section 4.4 shall remain in full force and effect and survive any termination of this JDA, other than any termination by Genomatica pursuant to Section 13.1(b). For a period of [...***...] after the termination of this JDA
(other than in the event of termination of this JDA (a) by Genomatica pursuant to Section 13.1(b), (b) pursuant to Section 13.2(b) or (c), or (c) pursuant to Section 13.2(d), which will be governed by
Section 4.2.2), Genomatica 

  

					
		 	25.	  	***Confidential Treatment Requested

 
will not enter into an agreement for the commercialization of Bio-BDO produced using the Commercial Process in the Territory with any Third Party that is a supplier of dextrose, unless Genomatica
proposes such terms to T&L and T&L does not accept such terms by written notice to Genomatica within sixty (60) days after notice of such terms from Genomatica. 
 ARTICLE XIV 
 GENERAL TERMS 

14.1. Non-Solicitation. During the term of this JDA and for a period of [...***...] after the termination of this JDA,
unless otherwise agreed to by the Parties, each Party agrees that it will not and will not permit its Affiliates to directly or indirectly solicit for employment or consulting any employee of the other Party or its Affiliates; provided that in no
event will listing or advertising any employee or consultant position in any publicly available source or hiring or engaging any person who contacts a Party or its Affiliate based upon such listing or advertisement be a breach of this
Section 14.1. 
 14.2. Force Majeure. The Parties shall be exempt from liability in respect of any failure to
perform their obligations under this JDA due to circumstances beyond their reasonable control, including but not limited to those arising from: (a) war, acts of terrorism, fire, epidemic, flood or other acts of God, explosion, civil commotion,
strike, lock-out or labor disturbances, acts, regulations or laws of any government, or failure of public utilities or common carriers, (b) inability to procure raw materials (other than dextrose) due to shortages of raw materials, or
(c) prevention from or hindrance in obtaining energy or other utilities. The Party so affected shall give written notice to the other Party of any such force majeure event and shall use its good faith efforts to avoid or remove such causes of
non-performance and to continue performance whenever such causes are removed. Should the event(s) of force majeure suffered by a Party extend beyond a three (3)-month period, the other Party may then terminate this JDA by written notice to the
non-performing Party, with the consequences of such termination as set forth in Section 13.3. 
 14.3.
Notices. Except as expressly set forth to the contrary in this JDA, all notices, requests, or consents provided for or permitted to be given under this JDA must be in writing and must be given either by depositing that writing in the
United States mail, addressed to the recipient, postage paid, and registered or certified with return receipt requested or by delivering that writing to the recipient in person, by courier, or by facsimile transmission; and a notice, request, or
consent given under this JDA is effective on receipt by the person to receive it. All notices, requests, and consents to be sent to a Party must be sent to or made at the following addresses (or such other address as that a Party may specify by
notice to the other Party). 
  

					
	 If to T&L:
	  	Tate & Lyle Ingredients Americas, Inc.	  	
		  	2200 East Eldorado Street	  	
		  	Decatur, IL 62521	  	
		  	Attention: General Counsel	  	
		  	Facsimile: (217) 421-4728	  	

  

					
		 	26.	  	***Confidential Treatment Requested

			
	 with a copy to:
	  	Tate & Lyle Ingredients Americas, Inc.
		  	2200 East Eldorado Street
		  	Decatur, IL 62521
		  	Attention: President
		  	Facsimile: (217) 421-4765
		
	
If to Genomatica, to:                  
  
	  	Genomatica, Inc.
		  	10520 Wateridge Circle
		  	San Diego, CA 92121
		  	Attention: Chief Technology Officer
		  	Facsimile: (858) 824-1772
		
	 with a copy to:
	  	Cooley LLP
		  	4401 Eastgate Mall
		  	San Diego, CA 92121
		  	Attention: Kay Chandler
		  	Facsimile: (858) 550-6420

 Whenever any notice is required to be given by law or this JDA, a written waiver thereof, signed by the person entitled
to notice, whether before or after the time stated therein, shall be deemed equivalent to the giving of such notice. 
 14.4.
Entire Agreement; Superseded. This JDA, together with the Exhibits hereto, constitutes the entire agreement of the Parties relating to the subject matter hereof and thereof and supersedes all prior contracts or agreements with respect to the
development of a process for Bio BDO, whether oral or written, including the NDA. 
 14.5. Effect of Waiver or Consent. A
waiver or consent, express or implied, to or of any breach or default by any Party in the performance by that Party of its obligations is not a consent or waiver to or of any other breach or default in the performance by that Party of the same or
any other obligations of that Party. Failure on the part of a Party to complain of any act of any Party or to declare the other Party in default, irrespective of how long that failure continues, does not constitute a waiver by that Party of its
rights with respect to that default until the applicable statute-of-limitations period has run. 
 14.6. Amendment or
Modification. This JDA may be amended, modified, or supplemented only by a written instrument duly executed by each of the Parties to, which instrument shall specifically indicate that it is the desire of the Parties to amend, modify or
supplement this JDA, and similarly may be waived only by a written instrument duly executed by the waiving Party. 
 14.7.
Binding Act. This JDA is binding on and inures to the benefit of the Parties and their respective heirs, legal representatives, successors, and assigns. 

  
 27.

 14.8. Governing Law. THIS JDA IS GOVERNED BY AND SHALL BE CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF DELAWARE, EXCLUDING ANY CONFLICT-OF-LAWS RULE OR PRINCIPLE THAT MIGHT REFER THE GOVERNANCE OR THE CONSTRUCTION OF THIS JDA TO THE LAW OF ANOTHER JURISDICTION. 

14.9. Severability. If any provision of this JDA or the application thereof to any Person or circumstance is held invalid or
unenforceable to any extent, the remainder of this JDA and the application of that provision to other Persons or circumstances is not affected thereby and that provision shall be enforced to the greatest extent permitted by Law. 

14.10. Further Assurances. In connection with this JDA and the transactions contemplated hereby, each Party shall execute and
deliver any additional documents and instruments and perform any additional acts that may be necessary or appropriate to effectuate and perform the provisions of this JDA and those transactions. 

14.11. No Third Party Beneficiaries. The provisions hereof are solely for the benefit of the Parties and are not intended to, and
shall not be construed to, confer a right or benefit on any other Person. 
 14.12. Counterparts. This JDA may be
executed in any number of counterparts with the same effect as if all Parties had signed the same document. All counterparts shall be construed together and constitute the same instrument. 

14.13. Assignability. Unless expressly provided otherwise in this JDA, no Party shall have the right to assign or otherwise
transfer its rights or obligations under this JDA, except with the written consent of the other Party, not to be unreasonably withheld or delayed; provided, however, that a Party may, without the other Party’s consent, assign or otherwise
transfer its rights or obligations under this JDA to (a) a successor in interest to all or substantially all of the business of such Party to which this JDA relates, whether by merger, sale of stock, sale of assets or otherwise, or
(ii) any Affiliate. In the event of any assignment of this JDA by a Party to an Affiliate pursuant to this Section 14.13, the assigning Party shall remain liable and responsible to the non-assigning Party hereto for the performance and
observance of all such rights and obligations by such Affiliate. Any assignment of this JDA in contravention of this Section 14.13 shall be null and void. 
 14.14. Resolutions of Disputes. 
 (a) The Parties will use
commercially reasonable efforts to resolve any dispute through good faith negotiations. If within [...***...] of any dispute being notified to the other Party the dispute has not been satisfactorily concluded, then unless otherwise agreed, the
Parties shall refer the dispute to the President of T&L and the Chief Executive Officer of Genomatica. If within [...***...] of the dispute being referred to the individuals referenced in the prior sentence the dispute has not been
satisfactorily concluded, 

  

					
		 	28.	  	***Confidential Treatment Requested

 then either Party may (but is not required to) refer the dispute for resolution pursuant to
Section 14.14(b). 
 (b) Following negotiations pursuant to Section 14.14(a), any remaining dispute,
controversy, or claim arising under, out of or relating to this JDA (and subsequent amendments thereof), its validity, binding effect, interpretation, performance, breach or termination, including tort claims, shall be finally determined by
arbitration administered by the American Arbitration Association under its Commercial Arbitration Rules, as in force at the time when the arbitration is initiated. The arbitral tribunal shall consist of three (3) mutually acceptable
arbitrators. The place of arbitration shall be [...***...]. Judgment on the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. 
 14.15. Headings and Recitals. The headings and recitals used herein are for ease of reference and information and do not affect the interpretation of the Article to which they relate or the
interpretation of this JDA in any other respect. 
 14.16. Limitation of Liability. IN NO EVENT SHALL EITHER PARTY BE
LIABLE TO THE OTHER OR ITS AFFILIATES FOR ANY SPECIAL OR CONSEQUENTIAL DAMAGES, REGARDLESS OF THE FORM OF ACTION, WHETHER IN CONTRACT, IN TORT INCLUDING NEGLIGENCE, BY STATUTE OR UNDER ANY QUASI-CONTRACTUAL THEORY OF LIABILITY, EVEN IF A PARTY HAS
BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. The foregoing limitations of liability and damages will not apply and nothing in this JDA shall affect either Party’s liability for breach of any obligation specified in Article X or either
Party’s indemnification obligations under Article XII. 
 [signature page follows] 

  

					
		 	29.	  	***Confidential Treatment Requested

 IN WITNESS WHEREOF, the Parties caused this Joint Development Agreement to be executed by
their duly authorized and empowered representatives as of the Effective Date. 
  

			
	 TATE & LYLE INGREDIENTS
 AMERICAS, INC.

		
	By:	 	 /s/ Matt Wineinger

	Title:	 	 President

	
	GENOMATICA, INC.
		
	By:	 	 /s/ William Baum

	Title:	 	 Executive Chairman

 SIGNATURE PAGE TO JOINT
DEVELOPMENT AGREEMENT 

 Schedule 1.2.18 
 Development Plan 
 BDO Demonstration Development Plan 

 
  
  

			
	

	 	

  
  

This document presents a Demonstration Development Plan aimed at establishing an integrated process for the production of 1,4-butanediol (BDO) from corn
wet mill dextrose. [...***...]. 
 This program is sub-divided in two work phases based on scale: 

1.) Lab scale (2-50 L) 
 2.)
Demonstration scale (13,000-15,000 L) 
 Details associated with [...***...]. Tasks, activities, timelines, responsibilities, milestones,
requirements (feedstock, resources, capital), and deliverables are outlined below in a development plan [...***...]. 
 This plan is a
living document that will be modified as needed to satisfy program requirements. 

  

					
		 	1.	  	***Confidential Treatment Requested

 1,4-Butanediol 
 1,4-Butanediol (BDO) is a major commodity chemical that currently is manufactured exclusively through various petrochemical routes requiring feedstocks such as acetylene, butane, propylene, and butadiene.
The demand for BDO stems largely from its use as an intermediate for the production of over 2.5 million tons of PBT plastic resins, polyurethane thermoplastics, co-polyester ethers, and spandex fibers. Given the importance of BDO as a chemical
intermediate and the issues associated with petroleum feedstocks, alternative low-cost renewable routes from sugars have been sought. Genomatica has engineered the first direct routes to BDO in E. coli and has developed a preliminary process
for the production and recovery of BDO from renewable carbohydrate feedstocks. This process has been demonstrated at both lab (2-30 L) and pilot (3000 L) scales and work continues [...***...]. 

Program Objectives 
 The main program
objective is to develop, scale-up, and confirm consistent performance of a robust process for the production BDO at demonstration scale (13,000-15,000 L). These studies will provide all data and capital equipment designs required for creating an
engineering package and constructing a manufacturing facility for conversion of corn wet mill dextrose to BDO. 
 A work plan for scale-up and
development of a “commercial ready” process and details associated with a full BDO demonstration development program are provided below. [...***...] 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 

  

					
		 	2.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	3.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	4.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	5.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	6.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	7.	  	***Confidential Treatment Requested

 [...***...] 
 Work Plan – Tasks, Activities, Responsibilities 
 A preliminary Work Plan is shown
below and includes a list of major tasks, activities, timelines, and responsibilities at the two phases of development: Lab Scale (2-50 L) and Demo Scale (13,000 L). 
 Lab Scale – Process Development (2-50 L) 
 [...***...] 

  

					
		 	8.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	9.	  	***Confidential Treatment Requested

 [...***...] 
 Demo Scale Development (13,000 L) 
 [...***...] 

  

					
		 	10.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	11.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	12.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	13.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	14.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	15.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	16.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	17.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	18.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	19.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	20.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	21	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	22.	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	23.	  	***Confidential Treatment Requested

 Schedule 1.2.24 
 [...***...] 

  

					
		 		  	***Confidential Treatment Requested

 Schedule 1.2.38 
 Polymer-grade Specifications 
 [...***...] 

  

					
		 		  	***Confidential Treatment Requested

 [...***...] 

  

					
		 		  	***Confidential Treatment Requested

 Schedule 3.4 
 Form of Corn Processing Agreement 
 CORN PROCESSING AGREEMENT

 This Corn Processing Agreement (the “Agreement”) is entered into as of the     day of
                    , between Tate & Lyle Ingredients Americas, Inc., with its principal place of business in Decatur, Illinois (hereinafter
“Tate & Lyle”), and Genomatica, Inc. with its principal place of business in “San Diego, California” (hereinafter “Customer”). 
 WITNESSETH THAT: 
 WHEREAS, Tate & Lyle owns corn wet milling plants in Lafayette,
Indiana, and Loudon, Tennessee, which process corn into [...***...] is hereinafter referred to as “corn sweetener”; 
 WHEREAS,
Customer and Tate & Lyle entered into a Joint Development Agreement dated as of March     , 2011 (as may be amended in accordance with its terms, the “JDA”), and capitalized terms used but not
otherwise defined in this Agreement shall have the meanings given such terms in the JDA; 
 WHEREAS, Customer wishes to have
Tate & Lyle process corn into corn sweetener and wishes to purchase from Tate & Lyle the corn sweetener resulting therefrom, and Tate & Lyle wishes to do so, in each case for use in the commercialization of Bio-BDO
produced using the Commercial Process in the first commercial facility in the Territory; 
 NOW, THEREFORE, in consideration of the premises and
the mutual obligations contained herein, the parties agree as follows: 
  

	I.	[...***...] 

[...***...] and are an integral part of this Agreement. 

 

	II.	Confidentiality  

Tate & Lyle and Customer agree that the terms of this Agreement, and the corn sweetener prices that result from this
Agreement are and shall remain confidential and, except as herein provided, will not be disclosed to any individual or organization during the term of this Agreement. Furthermore, 

  

					
		 	1	  	***Confidential Treatment Requested

 Tate & Lyle and Customer each agree to control information within their
respective organizations concerning all aspects of this Agreement. Nothing herein shall be deemed to prohibit such disclosures with respect to information that is now or hereafter becomes part of the public domain through no fault of the party
disclosing such information. Notwithstanding the foregoing, (i) Customer may disclose the terms of this Agreement and the corn sweetener prices that result from this Agreement to any joint venture or other Person in which Customer
has an economic interest which is involved in the commercialization of Bio-BDO produced using the Commercial Process in the first commercial facility in the Territory, provided that (A) in advance of any such disclosure, Customer
notifies Tate & Lyle of the name of any such joint venture partner or other Person and (B) any such Person is bound by confidentiality obligations consistent in all material respects with the terms of this Agreement that can be
enforced by Tate & Lyle; (ii) either party may disclose the existence, material terms, and the subject matter of this Agreement to the extent such disclosure is, in the reasonable judgment of a party, required by Law or stock exchange
listing requirements, and (iii) either party may disclose the terms of this Agreement and the corn sweetener prices that result from this Agreement: 
 (a) to its own employees or consultants who are subject to binding obligations concerning confidential information and inventions, to the extent such disclosure is reasonably necessary in connection
with the activities contemplated by the JDA or this Agreement, provided that such party shall be responsible for any breach thereof by its own employees or consultants; 
 (b) to the extent such disclosure is reasonably necessary for prosecuting or defending litigation or complying with applicable laws, rules or governmental regulations, provided that in the event a
party is required to make a disclosure of such information pursuant to this clause (b), it shall, except where impracticable or not permitted by Law, give reasonable advance notice to the other party of such disclosure and use commercially
reasonable efforts, at the cost of such other party, to secure confidential treatment of such information; 
 (c) to any
Person retained by such party to perform legal, accounting, engineering or similar services and who have a need to know such terms in order to provide such services, provided that any such Person is bound to confidentiality obligations consistent in
all material respects with the terms of this Agreement; and 
 (d) to Third Parties in connection with due diligence or
similar investigations by such Third Parties, provided that any such Third Party is bound to confidentiality obligations consistent in all material respects with the terms of this Agreement. 

 

	III.	Warranties: Limitation of Warranty 

  
 2 

 All corn sweeteners sold by Tate & Lyle pursuant to this Agreement shall conform
with the respective specifications thereof attached to this Agreement as Schedule B (“Specifications”). All corn sweeteners shall not be adulterated or misbranded within the meaning of the Food, Drug and Cosmetic Act (the
“Act”) nor articles which may not, under the provisions of Section 404 or 505 of the Act, be introduced into interstate commerce. TATE & LYLE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO
WARRANTIES OF FITNESS FOR ANY PARTICULAR PURPOSE OR ADEQUACY FOR ANY PARTICULAR RECIPE. 
  

	IV.	Limitation of Remedy and Liability 

 Upon request of Customer, Tate & Lyle will provide a certificate of analysis with all corn sweeteners delivered hereunder. Customer or its agent will examine and inspect all corn
sweeteners delivered hereunder promptly upon receipt and give prompt notice to Tate & Lyle of any defect or discrepancy from the Specifications and/or nonconforming delivery. Tate & Lyle shall remedy any such defect or discrepancy
by prompt replacement of any corn sweeteners promptly and properly rejected by Customer. The replacement remedy set forth above is Customer’s exclusive remedy, except that Customer shall have the right to terminate this
Agreement as provided in Section XII below. IN NO EVENT SHALL EITHER PARTY BE LIABLE FOR ANY INCIDENTAL, INDIRECT OR CONSEQUENTIAL DAMAGES, WHETHER ARISING IN CONTRACT, IN TORT OR OTHERWISE, INCLUDING BUT NOT LIMITED TO LOSS OF PROFITS, LOSS OF
BUSINESS AND/OR LOSS OF REPUTATION. 
  

	V.	Force Majeure  

 The
parties shall be exempt from liability in respect of any failure to perform their obligations under this Agreement due to circumstances beyond their reasonable control, including but not limited to those arising from: (a) war, acts of
terrorism, fire, epidemic, flood or other acts of God, explosion, civil commotion, strike, lock-out or labor disturbances, acts, regulations or laws of any government, or failure of public utilities or common carriers, (b) inability to procure
raw materials due to shortages of raw materials, or (c) prevention from or hindrance in obtaining energy or other utilities. The party so affected shall give written notice to the other party of any such force majeure event and shall use its
good faith efforts to avoid or remove such causes of non-performance and to continue performance whenever such causes are removed. If for any of the foregoing reasons beyond its reasonable control, Tate & Lyle is unable to supply the total
demand for processing of corn sweeteners, Tate & Lyle shall allocate its available processing and supply for each plant among all of its customers in an 

  
 3 

 equitable manner. If Tate & Lyle is unable to deliver or make available for
delivery quantities specified hereunder while a force majeure condition is in effect, Customer shall have the option to either cancel all or any part of the undelivered contract quantity affected by the force majeure event during such a force
majeure period, or take delivery of such volume on a later basis at such time as Tate & Lyle is able to perform; however, at all times [...***...] is and remains financially and otherwise responsible for [...***...] purchased,
and [...***...] under this Agreement. Should the event(s) of force majeure suffered by Tate & Lyle extend beyond a [...***...], Customer may then terminate this Agreement by written notice to Tate & Lyle.

  

	VI.	Assignment 

 Unless
expressly provided otherwise in this Agreement, neither Tate & Lyle nor Customer shall have the right to assign or otherwise transfer its rights or obligations under this Agreement, except with the written consent of the other party,
not to be unreasonably withheld or delayed; provided, however, that a party may, without the other party’s consent, assign or otherwise transfer its rights or obligations under this Agreement to (a) a successor in interest to all or
substantially all of the business of such party to which this Agreement relates, whether by merger, sale of stock, sale of assets or otherwise, or (b) any direct or indirect subsidiary of the assigning party, any corporation which owns more
than 50% of the stock of the assigning party, or any corporation 50% or more of the stock of which is owned by common parent corporation. In the event of any assignment of this Agreement by a party pursuant to subsection (b) of the prior
sentence, the assigning party shall remain liable and responsible to the non-assigning party hereto for the performance and observance of all such rights and obligations by the assignee of this Agreement. Any assignment of this Agreement in
contravention of this Section VI shall be null and void. In addition, Tate & Lyle may assign this Agreement in whole or in part to any entity which buys or leases all or part of Tate & Lyle’s facilities dedicated to the
manufacture of corn sweeteners or a transfer of all or a portion of Tate & Lyle’s assets dedicated to the manufacture of corn sweeteners, whether by sale of assets or stock, merger, operation of law or otherwise. Subject to the
foregoing, this Agreement shall inure to the benefit of, and be binding upon, Tate & Lyle, Customer and their respective successors and assigns. 
  

	VII.	Counterparts 

 This
Agreement may be executed in one or more counterparts, all of which shall be considered one and the same agreement, and shall 

  

					
		 	4	  	***Confidential Treatment Requested

 become effective when one or more counterparts have been signed by each of the parties and
delivered to the other party. 
  

	VIII.	Entire Agreement 

 This
Agreement and the Schedules hereto contain the entire agreement between the parties with respect to the subject matter hereof and there are no agreements, understandings, representations or warranties between the parties other than those set forth
or referred to herein. 
  

	IX.	Amendments and Waivers 

This Agreement may not be modified or amended except by an instrument or instruments in writing signed by the party against whom
enforcement of any such modification or amendment is sought. Tate & Lyle may waive compliance by Customer or Customer may waive compliance by Tate & Lyle with any term or provision of this Agreement on the part of
such party to be performed or complied with, but only by an instrument in writing signed by the party that is waiving compliance. The waiver by any party hereto of a breach of any term or provision of this Agreement shall not be construed as a
waiver of any subsequent breach. 
  

	X.	Notices 

 Notices required
or given under the terms of this Agreement shall be deemed to have been duly given upon delivery in person or by facsimile transmission or upon receipt if delivered by courier service or by U.S. mail, first class postage prepaid, as follows:

  

			
		  	Tate & Lyle Ingredients Americas, Inc.
		  	2200 East Eldorado Street
		  	Decatur, Illinois 62525
		  	Attention: General Counsel
		  	Facsimile: (217) 421-4728
		
	Copy to:	  	Tate & Lyle Ingredients Americas, Inc.
		  	2200 East Eldorado Street
		  	Decatur, Illinois 62525
		  	Attention: Vice President Sweetener Sales
		  	Facsimile:                         
		
		  	Genomatica, Inc.
		  	10520 Wateridge Circle
		  	San Diego, CA 92121
		  	Attention: Chief Technology Officer
		  	Facsimile: (858) 824-1772

  
 5 

	XI.	Applicable Law 

 THIS
AGREEMENT IS GOVERNED BY AND SHALL BE CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF DELAWARE, EXCLUDING ANY CONFLICT-OF-LAWS RULE OR PRINCIPLE THAT MIGHT REFER THE GOVERNANCE OR THE CONSTRUCTION OF THIS AGREEMENT TO THE LAW OF ANOTHER
JURISDICTION. 
  

	XII.	Termination  

 This
Agreement may be terminated: 
  

	 	(a)	by mutual written consent of Tate & Lyle and Customer; 

  

	 	(b)	by Customer in the event Tate & Lyle has breached in any material respect any representation, warranty, covenant or agreement of Tate & Lyle
contained in this Agreement, Customer has notified Tate & Lyle of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach; or 

 

	 	(c)	by Tate & Lyle in the event Customer has breached in any material respect any representation, warranty, covenant or agreement of Customer
contained in this Agreement, Tate & Lyle has notified Customer of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach.

 

	XII.	Scope of Agreement  

 This
Agreement shall apply only to the supply of corn sweetener for use in production of Bio-BDO using the Commercial Process in the first commercial facility in the Territory. 

  
 6 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first written above.

  

					
		 	TATE & LYLE INGREDIENTS AMERICAS, INC.
			
		 	 By
	 	 
		 	
			
		 	 Its
	 	 
		
		 	GENOMATICA, INC.
			
		 	 By
	 	 
		 	
			
		 	 Its
	 	 
		 	

  

					
		 	7	  	***Confidential Treatment Requested

 Schedule A 
 Corn Sweetener [...***...]  
  

	I.	Quantity 

 A.
[...***...] 
 B. Corn
Sweetener                    [...***...] 
 [...***...] 
 [...***...] 

 

	II.	Term of Agreement 

 This
Agreement shall be for a period of five (5) years after commencement of this Agreement in accordance with Section 3.4 of the Joint Development Agreement dated as of March     , 2011 by and between Customer and
Tate & Lyle, unless earlier terminated as provided in Section XII of this Agreement. 
  

	III.	Pricing Formula for Net Plant Corn Sweetener Price 

 A. Pricing Formula 
 [...***...] 

  

					
		 	8	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	9	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	10	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	11	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	12	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	13	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	14	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	15	  	***Confidential Treatment Requested

 [...***...] 

 

	IV.	Products 

 This Agreement
covers the purchase of Corn Sweetener. 
  

	V.	Distribution Charges 

Distribution charges for product received at a location other than the Tate & Lyle production facility will be based upon actual
costs to Tate & Lyle, and are subject to quarterly review and revision prior to the beginning of each quarter. 
  

	VI.	Payment Terms 

 Payment
will be due within 30 days of date of invoice. “Net 30 Days” 

  

					
		 	16	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	17	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	18	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	19	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	20	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	21	  	***Confidential Treatment Requested

 [...***...] 

  

					
		 	22	  	***Confidential Treatment Requested

 Schedule 4.1 
 Activities to be Completed by Genomatica 
 With respect to the Commercial Facility:

 [...***...] 

  

					
		 	1	  	***Confidential Treatment Requested

 Schedule 9.2 
 Limited Materials/Products 
  

			
	 Chemical
	  	 Number of years following
 [...***...] that T&L limitation

on sublicense applies

	
                        
            [...***...]
	  	                             
       [...***...]
	
                        
            [...***...]
	  	                             
       [...***...]

  

					
		 	1	  	***Confidential Treatment RequestedJoint Development Agreement

 Exhibit 10.22 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange
Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406 

JOINT DEVELOPMENT AGREEMENT 
 This Joint Development Agreement (this “JDA”), is dated as of this 15th day of April, 2011 (“Effective Date”), by and between Genomatica, Inc., a Delaware corporation with
principal offices located at 10520 Wateridge Circle, San Diego, California 92121 (hereinafter referred to as “Genomatica”), and Chemtex Italia S.r.l., an Italian corporation with principal offices located at Strada Ribrocca n. 11,
15057 Tortona (AL), Italy (hereinafter referred to as “Chemtex”). 
 RECITALS: 

WHEREAS, Genomatica has invented and developed proprietary technology and recombinant microorganisms to produce 1,4-butanediol
(“Bio-BDO”); 
 WHEREAS, Chemtex has invented and developed the proprietary PROESATM process, which
converts Biomass to cellulosic sugars; 
 WHEREAS, Genomatica and Chemtex have evaluated the economic feasibility of a
biological route for the manufacture of Bio-BDO using Biomass cellulosic sugars; 
 WHEREAS, Genomatica and Chemtex mutually
desire to join their respective strengths in a relationship for the joint development of a process combining their respective processes for producing renewable Bio-BDO from Biomass feedstocks; and 

WHEREAS, each Party recognizes it may be necessary or desirable to grant to the other Party access to certain intellectual property in
order to carry out the objectives of this JDA. 
 NOW THEREFORE, Genomatica and Chemtex agree to the following terms and
conditions: 
 ARTICLE I 
 DEFINITIONS 
 1.1. Previously Defined Terms. Each term defined in
the preamble and the Recitals to this JDA shall have the meaning set forth above whenever used herein. 
 1.2.
Definitions. In addition to the terms defined in the preamble and the Recitals of this JDA, the following terms, whenever used herein, shall have the meanings set forth below: 

1.2.1 “Affiliate” shall mean, with respect to any specified Person, any other Person that directly, or indirectly
through one or more intermediaries, controls, is controlled by, or is under common control with, such specified Person, and for this 

  
 1 

 
purpose, “control,” “controlled by” and “common control” shall mean the ownership and voting control of more than 50% of the outstanding voting securities or
interest in capital or profits of such specified Person, or the right to direct or control the management or affairs of such specified Person by contract or similar arrangement. Should a Person divest an Affiliate or should an Affiliate cease to
satisfy this definition, such Affiliate’s rights and obligations under this JDA shall be terminated. 
 1.2.2
“Background Intellectual Property” shall mean all Intellectual Property first conceived, reduced to practice and/or otherwise acquired or obtained by a Party prior to the Effective Date of this JDA or outside of the course of the
Joint Development Program and during the term of this JDA, including rights arising in the course of prosecution and maintenance of such Intellectual Property, which such Party discloses or otherwise provides to the other Party for use in the Joint
Development Program. 
 1.2.3 “Bio-BDO Field” shall mean the biological manufacture of Bio-BDO from sugars
produced from Biomass and the marketing and the sale of Bio-BDO manufactured from sugars produced from Biomass, and includes research and development related to the foregoing. 
 1.2.4 “Biomass” shall mean any non-food agriculture plant (such as but not limited to poplar, eucalyptus and energy crops) and agricultural waste (such as but not limited to straw, corn
stover and sugar cane bagasse) that can be used as a renewable non-food feedstock for the production of sugars (which non-food feedstock excludes, without limitation, first generation food feedstocks of corn, wheat, sugar beets and sugar cane).

 1.2.5 “Bioprocess” shall mean a fermentation process using microorganisms for the production of Bio-BDO, and
including the downstream Bio-BDO purification steps. 
 1.2.6 “Chemtex Confidential Information” shall mean any
Confidential Information of Chemtex. 
 1.2.7 “Chemtex Intellectual Property” shall mean (a) all
Background Intellectual Property owned or licensed (with the right to grant licenses or sublicenses) by Chemtex which claims or covers all or part of the PROESATM Process Technology, and (b) all JDA Intellectual Property owned by Chemtex.

 1.2.8 “Commercialization KPIs” shall have the meaning set forth in Section 3.1(b). 

1.2.9 “Commercial Process” shall have the meaning set forth in Section 2.1. 

1.2.10 “Confidential Information” shall mean any and all proprietary information and materials, in any form (written,
oral, photographic, electronic, magnetic, or otherwise), including without limitation, information related to technical, business, and 

  
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intellectual property matters, intellectual property including know-how, data, trade secrets, and all documents and other physical materials relating to prototypes, materials, compositions,
devices, methods, or procedures related to the research and development, manufacture, use or sale of Bio-BDO. Confidential Information of a Party disclosed pursuant to the NDA shall be treated as Confidential Information under this JDA. The Chemtex
Intellectual Property shall be Confidential Information of Chemtex, and the Genomatica Intellectual Property shall be Confidential Information of Genomatica. 
 1.2.11 “Damages” shall have the meaning set forth in Section 13.1. 
 1.2.12 “Development Plan” shall mean the plan for activities to be conducted under the Joint Development Program which is set forth in Schedule 1.2.12, including deliverables, estimated
timelines and budget, which may be amended by the JDC pursuant to Section 5.2. 
 1.2.13 “Facilities”
shall mean the Chemtex facilities located in Rivalta Scrivia (AL) – Italy. 
 1.2.14 “Genomatica Confidential
Information” shall mean any Confidential Information of Genomatica. 
 1.2.15 “Genomatica Intellectual
Property” shall mean (a) all Background Intellectual Property owned or licensed (with the right to grant licenses or sublicenses) by Genomatica, which claims or covers all or part of a Bioprocess, including the components (including
Genomatica Microorganisms) used in a Bioprocess, (b) all Process Intellectual Property, and (c) all JDA Intellectual Property owned by Genomatica. 
 1.2.16 “Genomatica Microorganism(s)” shall mean microorganisms designated by Genomatica and identified in Schedule 1.2.16 and which may be supplied by Genomatica during the term of the
Joint Development Program. 
 1.2.17 “Intellectual Property” shall mean all (a) Patent Rights,
(b) trademarks, service marks, domain names, trade dress, logos, trade names, and corporate names and registrations and applications for registration thereof, (c) copyrights and registrations and applications for registration thereof,
(d) computer software, data, and documentation, (e) trade secrets and confidential business information, whether patentable or unpatentable and whether or not reduced to practice, know-how, manufacturing and production processes and
techniques, research and development information, copyrightable works, financial, marketing and business data, pricing and cost information, business and marketing plans and customer and supplier lists and information, (f) other proprietary
rights relating to any of the foregoing, and (g) copies and tangible embodiments thereof. 
 1.2.18 “JDA
Intellectual Property” shall mean all Intellectual Property first conceived, reduced to practice and/or otherwise acquired or obtained solely by a Party or jointly by the Parties in the course of and during the term of the Joint Development
Program, including rights arising in the course of prosecution and 

  
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maintenance of such Intellectual Property, but excluding all Process Intellectual Property. 
 1.2.19 “Joint Development Committee” or “JDC” shall mean the joint committee established pursuant to Article V. 

1.2.20 “Joint Development Program” shall mean the joint program undertaken by the Parties under this JDA as described in
Articles II and III. 
 1.2.21 “Law” shall mean any federal, state, regional, local, or foreign law,
constitution, rule, statute, ordinance, regulation, order, code, judgment, charge, writ, injunction, or decree. 
 1.2.22
“MOU” shall have the meaning set forth in Section 1.2.32. 
 1.2.23 “NDA” shall mean the
nondisclosure agreement between the Parties dated 19 March 2010 between M&G Finanziaria S.r.l. and Genomatica and covering also M&G Finanziaria Affiliates, which includes Chemtex. 

1.2.24 “Party” shall mean Genomatica or Chemtex, as the case may be, and “Parties” shall mean
Genomatica and Chemtex. 
 1.2.25 “Patent Rights” shall mean any patent application, certificate of invention,
application for certificate of invention, priority patent filing or patent (foreign or domestic), including any and all divisionals, continuation (in whole or in part), request for continued examination, reissues, reexaminations, additions,
substitution cases, confirmations, registrations, revalidations, revisions, renewals and extensions thereof. 
 1.2.26
“Person” shall mean an individual or a corporation, partnership, limited liability company, trust, incorporated or unincorporated association, joint venture, joint stock company, government (or an agency or political subdivision
thereof) or other entity of any kind. 
 1.2.27 “Pilot Phase” shall have the meaning set forth in
Section 2.2. 
 1.2.28 “Pilot Plant Facility” shall have the meaning set forth in Section 2.1.

 1.2.29 “Process Intellectual Property” shall mean all Intellectual Property relating to all or
part of a Bioprocess, including any components (including microorganisms) used in a Bioprocess, and/or the basic engineering package that uses or incorporates the Bioprocess, which Intellectual Property is first conceived, reduced to practice and/or
otherwise acquired or obtained solely by a Party or jointly by the Parties in the course of and during the term of the Joint Development Program, including rights arising in the course of prosecution and maintenance of such Intellectual Property.
For clarification, Process Intellectual Property excludes all Background Intellectual Property. 

  
 4 

 1.2.30 “PROESATM Intellectual Property” shall mean all Intellectual
Property relating to all or part of PROESATM Process Technology, including any components used in PROESATM Process Technology, and/or the basic engineering package that uses or incorporates the PROESATM Process Technology, which
Intellectual Property is first conceived, reduced to practice and/or otherwise acquired or obtained solely by a Party or jointly by the Parties in the course of and during the term of the Joint Development Program, including rights arising in the
course of prosecution and maintenance of such Intellectual Property. For clarification, PROESATM Intellectual Property excludes all Background Intellectual Property. 
 1.2.31 “PROESATM License” shall have the meaning set forth in Section 3.3. 
 1.2.32 “PROESATM License Agreement” shall mean the license in the Bio-BDO Field granted by Chemtex to Genomatica for the use of the PROESATM Technology, PROESATM Intellectual
Property and Chemtex Intellectual Property in the Commercial Process where the scope of the license and the applicable conditions are as set out in the “Biomass to Chemicals Partnership Memorandum of Understanding (MOU)” between Genomatica
and Gruppo M&G dated February 14, 2011 (hereinafter referred to as the “MOU”). The MOU is attached hereto as Schedule 1.2.36. 
 1.2.33 “PROESATM Process Technology” shall mean the process configuration, operating parameters and conditions, the equipment set up and/or the equipment design to produce fermentable
sugar or precursor of fermentable sugar from Biomass [...***...]. For clarification, PROESATM Process Technology does not include any technology (including, but not limited to, process configuration, operating parameters and conditions,
equipment set up and/or equipment design) with respect to any portion of a process using fermentable sugar, including, without limitation, any process for fermentation of fermentable sugars. 

1.2.34 “Representatives” shall mean, with respect to any Person, the directors, officers, employees, agents, Affiliates,
or other representatives of such specified Person, including, without limitation, financial advisors, consultants, and counsel. 

1.2.35 “Territory” shall mean the world. 
 1.2.36 “Third Party(ies)” shall mean any Person other than Genomatica and its Affiliates or Chemtex and its Affiliates. 

1.2.37 “Third Party Agreement” shall have the meaning set forth in Section 3.3. 

  

					
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 ARTICLE II 
 JOINT DEVELOPMENT PROGRAM OBJECTIVES 
 2.1. Objectives. The purpose
of the Parties’ relationship under this JDA is to further develop Genomatica’s current Bioprocess at the Chemtex’s PROESATM pilot plant located at the Facilities (the “Pilot Plant Facility”) to produce Bio-BDO
from cellulosic sugars produced from Biomass feedstocks by modifying the Pilot Plant Facility to develop Genomatica’s current Bioprocess into a continuous or semi-continuous commercially viable Bioprocess for producing Bio-BDO from cellulosic
sugars generated using Biomass feedstocks via PROESATM Process Technology (collectively, the “Commercial Process”) at a competitive cash cost relative to petroleum-based BDO. The Parties also desire to discuss options to work
together to commercialize in the Territory, Bio-BDO produced using the Commercial Process and Biomass feedstocks at a commercial manufacturing facility co-located with a Third Party. 

2.2. Pilot Phase. During the period of performance of the Joint Development Program (the “Pilot Phase”), the
objective is to demonstrate the ability to manufacture Bio-BDO via the Bioprocess using cellulosic sugars generated from Biomass feedstocks via the PROESATM Process Technology in the Pilot Plant Facility. The principal tasks in the Pilot Phase
shall consist of those matters set forth in the Development Plan. 
 ARTICLE III 

PILOT PHASE 
 3.1. Pilot Phase. 
 (a) During the Pilot Phase, the
responsibility of the Parties for costs and expenses will be as set forth in Schedule 3.1(a). Without the approval of the JDC, neither Party will incur any capital expenditures in the performance of the Pilot Phase except as expressly set forth in
the Development Plan. 
 (b) [...***...]. The JDC will determine whether the technical and commercial key
performance indexes (KPIs) for the Pilot Phase, as set forth in the Development Plan (the “Commercialization KPIs”) have been satisfied. The Pilot Phase will continue until the date that the principal tasks in the Development Plan
(and any other tasks reasonably determined by Genomatica) have been completed, whether or not the Commercialization KPIs have been satisfied. 
 3.2. Deliverables. 
 1. Genomatica Deliverables. 

(a) During the Pilot Phase, Genomatica will be responsible for (i) transferring to the Pilot Plant Facility
[...***...] which will be subject to review by Chemtex, with the [...***...] approved by the JDC and will comply with safety and environmental standards 

  

					
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required for activities conducted at the Pilot Plant Facility, and (ii) completing the [...***...], in each case subject to having sufficient data regarding the Pilot Plant Facility to
enable such activities. 
 (b) During the Pilot Phase, Genomatica will be responsible for providing information
regarding Genomatica’s actual Bioprocess costs for use in jointly developed cost models,which are currently cost advantaged relative to petroleum-based BDO plant costs, using dextrose. These costs will be subject to review by Chemtex, through
the JDC. 
 2. Chemtex Deliverables. 

(a) During the Pilot Phase, Chemtex will be responsible [...***...]. 

(b) During the Pilot Phase, Chemtex will be responsible for the following: 

(i) providing Biomass feedstock to produce cellulosic sugars; 

(ii) providing engineering and manufacturing expertise and experience to [...***...]; and 

(iii) providing Bio-BDO product support services, including [...***...]. 

(c) During the Pilot Phase, Chemtex will be responsible for providing information regarding Chemtex’s actual cost for
PROESATM Process Technology based upon a Biomass standard cost of [...***...] $/t d.m. for use in jointly developed cost models. These costs will be subject to review by Genomatica, through the JDC. 

3. Joint Deliverables. The Parties will be jointly responsible for the following deliverables under the Development Plan:

 (a) jointly developing the overall process cost model, including the PROESATM cellulosic sugar cost model
and the Bio-BDO cost model, that is required to manufacture competitive Bio-BDO; and 
 (b) preparing the PDP for
the overall process on the basis of the result of the Pilot Phase, and 
 (c) coordinating any external
communications regarding the Development Plan. 

  

					
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 3.3. Commercialization Structure. During the Pilot Phase, the Parties will discuss
how to work together to commercialize Bio-BDO in the Territory using the Commercial Process. [...***...]. 
 ARTICLE IV

 COMMERCIALIZATION 
 4.1. Commercialization Process License. Upon completion of the Pilot Phase, provided that the Bio-BDO produced in the Pilot Phase meets minimum standards of quality and costs, applicable to
petroleum-based BDO, which specifications are described on Schedule 4.1, Genomatica will enter into Third Party Agreement discussions and provide written notice to Chemtex identifying the potential Third Party licensee. Genomatica will bear
all expenses it incurs in executing Third Party Agreements. 
 4.2. Negotiation of PROESATM License Agreement. The
Parties will negotiate in good faith the definitive agreements for the PROESATM License Agreement for the commercialization of Bio-BDO produced using the Commercial Process, including the PROESATM Process Technology, in the Territory.

 4.3. Supply of Biomass Feedstock. [...***...]. 

ARTICLE V 

GOVERNANCE OF THE JOINT DEVELOPMENT PROGRAM 
 5.1. Formation of Joint Development Committee (JDC). Promptly following the Effective Date, the Parties shall form the JDC, and each Party will appoint two of its employees to serve on the JDC. The
purpose of the JDC is to oversee, guide, and monitor the conduct of the Joint Development Program under the terms of this JDA. To ensure the success of the Joint Development Program, the JDC will meet regularly and at least quarterly to review the
progress towards the objectives of the Joint Development Program. Such meetings may be held in person, or by any means of telecommunications 

  

					
		  	8	  	***Confidential Treatment Requested

 
or video conference, as the JDC members deem necessary or appropriate. The JDC will keep minutes of its meetings, including at a minimum who is in attendance, the subject matter discussed or
considered, and any action taken. Decisions of the JDC will be made by unanimous approval, with the representatives of Genomatica collectively having one vote and the representatives of Chemtex collectively having one vote. If the JDC is unable to
reach agreement on any matter properly before it, then either Party may, by written notice to the other Party, have such matter referred for resolution pursuant to Section 14.14. 

5.2. Responsibilities of JDC. The JDC shall have the following responsibilities and authority: 

 

	 	(a)	to provide a means of communication between the Parties regarding the Joint Development Program; 

 

	 	(b)	subject to and within the parameters of the Development Plan, to monitor and oversee the implementation of the Development Plan; 

 

	 	(c)	to review and approve any amendments or modifications to the Development Plan; and 

 

	 	(d)	such other responsibilities as expressly assigned to the JDC under this JDA or by written agreement of the Parties. 

5.3. Reservation of Rights. Matters outside the scope of the Joint Development Program and internal to each Party are not under
the purview of the JDC. Such matters include but are not limited to internal personnel policies and programs, budgeting, finance, commercial and marketing strategies, and business decisions. However, the Parties agree to communicate with each other
promptly on those matters which, while outside the scope of the Joint Development Program, nevertheless may reasonably be expected to affect the Joint Development Program. 
 5.4. Independent Contractors. Each party is an independent contractor and shall retain complete control and responsibility for its own operations and employees. Nothing in this JDA shall be
construed to constitute either Party as a partner, agent or representative of the other Party. Neither Party shall have the right or authority to assume or create any obligation on behalf of or in the name of the other, or to bind the other in any
manner whatsoever. 
 ARTICLE VI 
 ADDITIONAL OBLIGATIONS OF CHEMTEX 
 6.1. Supply of Storage Equipment and
Instrumentation. Chemtex shall supply [...***...]. 

  

					
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 6.2. Installation of Equipment and Instrumentation. Chemtex shall coordinate the
installation of all equipment and instrumentation (including any Genomatica-supplied equipment or instrumentation) at the Facilities. The equipment and instrumentation, together with the Facilities, shall be accessible, upon reasonable prior notice,
to Genomatica employees assigned to support the Joint Development Program. 
 6.3. Services. Chemtex shall supply
(i) technical and engineering services for the Facilities and (ii) employees to operate the Facilities. 
 6.4.
Access to Information and Data. Chemtex shall provide Genomatica reasonable access to all Confidential Information, technical information, and data used during and data generated from the startup and operation of the Facilities. 

ARTICLE VII 

ADDITIONAL OBLIGATIONS OF GENOMATICA 
 7.1. [...***...]. During the Pilot Phase and in accordance with the Development Plan, Genomatica shall [...***...] pursuant to this JDA. 

7.2. [...***...] [....***...] required to be supplied by Genomatica under the Development Plan as well as [...***...]
defined in detail in the Development Plan. 
 7.3. Availability of Technical Employees. Genomatica shall make available
such technical employees at the Facilities reasonably required by Chemtex to assist in the development of the Bioprocess as provided in the Development Plan. Genomatica shall cause its employees to comply with Chemtex’s safety, health, and
environmental policies and procedures. 
 ARTICLE VIII 

INTELLECTUAL PROPERTY 
 8.1. Background Intellectual Property. Each Party acknowledges and agrees that, as between the Parties, each Party is and shall remain the sole and exclusive owner of all right, title, and interest
in and to its Background Intellectual Property, and that this JDA does not affect such ownership. Each Party acknowledges that it acquires no rights under this JDA to the other Party’s Background Intellectual Property other than the limited
rights specifically granted in this JDA. 
 8.2. Process Intellectual Property. All Process Intellectual Property, other
than the PROESATM Intellectual Property, will be owned by Genomatica. Chemtex hereby irrevocably transfers, conveys and assigns to Genomatica all of its right, title, and interest in the Process Intellectual Property, other than the PROESATM
Intellectual Property, and agrees to execute such documents, render such assistance, and take such other action as Genomatica may reasonably request, at Genomatica’s expense, to apply for, register, perfect, confirm, and protect
Genomatica’s ownership rights in such Process Intellectual 

  

					
		  	10	  	***Confidential Treatment Requested

 
Property. The Parties shall use commercially reasonable efforts to promptly disclose and jointly identify all Process Intellectual Property during the term this JDA. Under the PROESATM
License Agreement, Chemtex will grant to Genomatica the exclusive right under the Chemtex Intellectual Property and PROESATM Intellectual Property to use the PROESATM Process Technology with and as part of the Commercial Process. Chemtex
shall render such assistance, and take such other action as Genomatica may reasonably request, to protect Genomatica’s license rights in the Chemtex Intellectual Property and PROESATM Intellectual Property. 

8.3. JDA Intellectual Property. JDA Intellectual Property first conceived or reduced to practice solely by employees and/ or
consultants of a Party shall be owned solely by such Party, and JDA Intellectual Property first conceived or reduced to practice jointly by employees and/or consultants of both Parties shall be owned jointly by the Parties. A Party shall have the
exclusive right to apply for or register any patents and other proprietary protections with respect to the JDA Intellectual Property solely owned by such Party, including, for example, improvements, modifications, or uses of existing technology in
different areas. The Parties through the JDC shall agree which Party shall apply for and register any patents and other proprietary protections with respect to the JDA Intellectual Property jointly owned by the Parties, and shall cooperate in such
activities, including sharing copies of filings with adequate time for review and comment by the other Party, and assembling inventorship information and data for filing such patent applications. Each Party shall have the right to use and practice,
and grant licenses to use and practice, all jointly owned JDA Intellectual Property, without the consent of or any duty of accounting to the other Party; provided that Chemtex shall not have the right to use and practice, or grant licenses to use
and practice, jointly owned JDA Intellectual Property for the development, production, sale and distribution of BDO; and provided that Genomatica shall not have the right to use and practice, or grant licenses to use and practice, jointly owned JDA
Intellectual Property for the development, production, sale and distribution of a [...***...] process. 
 8.4. No Implied
Licenses. No license or right is granted by implication or otherwise with respect to any patent application or patent except as may be specifically set forth in this JDA. Chemtex and Genomatica will promptly notify the other in writing if such
Party (a) becomes aware of any Intellectual Property of a Third Party that would be infringed by the activities under the Joint Development Program, (b) receives a written claim or notice of infringement of any Intellectual Property of a
Third Party related to the activities under the Joint Development Program or (c) is sued for infringement of any Intellectual Property of a Third Party as a result of the activities under the Joint Development Program. 

ARTICLE IX 

GRANT OF RIGHTS 
 9.1. Limited License for Joint Development Program. Subject to the terms and conditions of this JDA, Genomatica hereby grants to Chemtex a non-exclusive, non-sublicensable (except to Chemtex’s
Affiliates), royalty-free license to use Genomatica Intellectual Property directly relevant to the Joint Development Program within the Pilot 

  

					
		  	11	  	***Confidential Treatment Requested

 
Plant Facility, solely for purposes of performing Chemtex’s obligations under the Joint Development Program during the term of this JDA. Subject to the terms and conditions of this JDA,
Chemtex hereby grants to Genomatica a non-exclusive, non-sublicensable (except to Genomatica’s Affiliates), royalty-free license to use Chemtex Intellectual Property and PROESATM Intellectual Property directly relevant to the Joint
Development Program within the Territory solely for purposes of performing Genomatica’s obligations under the Joint Development Program during the term of this JDA. If a Party grants a sublicense of the license under this Section 9.1 to
any of its Affiliates, such Party shall cause its Affiliates to comply with all obligations of such Party hereunder, including, without limitation, Articles VIII and X; provided that such Party shall at all times be fully responsible for the
performance of such Affiliate. 
 9.2. Reservation of Rights to Intellectual Property. Chemtex reserves all rights under
the Chemtex Intellectual Property and PROESATM Intellectual Property, subject only to the license granted to Genomatica in Section 9.1, and Genomatica reserves all rights under the Genomatica Intellectual Property, subject only to the
licenses granted to Chemtex in Section 9.1. Notwithstanding anything to the contrary in this JDA, the Parties acknowledge and agree that general knowledge about operation of the Facilities learned or observed in the course of the Joint
Development Agreement may be used by either Party. 
 9.3. Mutual Agreements. Chemtex agrees not to practice the
Genomatica Intellectual Property and the JDA Intellectual Property developed jointly by the Parties, and Genomatica agrees not to practice the Chemtex Intellectual Property, PROESATM Intellectual Property and the JDA Intellectual Property
developed jointly by the Parties, in each case except as expressly permitted in this JDA or other written agreement between the Parties. 
 9.4. No Use of Names. Except as otherwise provided herein, no right, express or implied, is granted by this JDA to use in any manner the name “Chemtex” or “Genomatica” or any
other trademark, service mark, or trade name of the other Party in connection with the performance of this JDA. 
 ARTICLE X

 CONFIDENTIAL INFORMATION 
 10.1. Confidentiality. Each Party (in such capacity, the “receiving Party”) agrees to maintain the confidentiality of, and not disclose to any other Person, all Confidential Information
of the other Party (in such capacity, the “disclosing Party”) and not to use the Confidential Information of the other Party except for the purposes of this JDA or pursuant to the terms of a Commercialization Agreement, in each case for
[...***...] from the Effective Date of this JDA. The obligation of confidentiality, nondisclosure and nonuse shall not apply to Confidential Information which: 
  

	 	(a)	is or becomes public through no fault of the receiving Party; 

  

					
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	 	(b)	is known by the receiving Party at the time of disclosure as shown by prior written records; 

 

	 	(c)	is disclosed to the receiving Party by a Third Party entitled to disclose it without obligation of confidentiality, [...***...]

 

	 	(d)	[...***...]. 

 10.2.
Permitted Disclosures. Each Party may disclose Confidential Information belonging to the other Party: 

(a) to its own employees or consultants who are subject to binding obligations concerning confidential information and
inventions, to the extent such disclosure is reasonably necessary in connection with the activities contemplated by this JDA, provided that the disclosing Party shall be responsible for any breach thereof by its own employees or consultants;

 (b) to the extent such disclosure is reasonably necessary for filing or prosecuting patents as expressly
permitted by Article VIII; or 
 (c) to the extent such disclosure is reasonably necessary for prosecuting or
defending litigation or complying with applicable laws, rules or governmental regulations, providing that in the event a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to this clause (c), it shall,
except where impracticable or not permitted by Law, give reasonable advance notice to the other Party of such disclosure and use commercially reasonable efforts, at the cost of the other Party, to secure confidential treatment of such information.

 10.3. Permitted Disclosure of Material Terms of this JDA. A Party shall have the right to disclose the material terms
of this JDA (a) to any Person retained by such Party to perform legal, accounting, engineering or similar services and who have a need to know such terms in order to provide such services and (b) to Third Parties in connection with due
diligence or similar investigations by such Third Parties, provided that any such Person or Third Party is bound to confidentiality obligations consistent in all material respects with the terms of this Article X. 

10.4. Publicity. In any event, each Party agrees to take all reasonable action to avoid disclosure of the other Party’s
Confidential Information hereunder. Promptly following the Effective Date, the Parties will coordinate issuing a press release concerning this JDA (which may be a joint press release or separate press releases by each Party), subject to mutual
agreement of the Parties on the content of such press release. If either Party desires to, or is required by Law or stock exchange requirements to, make a public announcement concerning this JDA or the subject matter hereof after such initial press
release, such Party shall give reasonable prior advance notice of the proposed text of such announcement to the other Party for its prior review and comment. 

  

					
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 10.5. JDA Terms Are Confidential Information of Both Parties. Except for public
statements agreed to by the Parties or for disclosures that are in the reasonable judgment of a Party required by Law or stock exchange listing requirements, the Parties agree that the existence, material terms, and the subject matter of this JDA
shall be considered Confidential Information of both Parties. 
 10.6. Equitable Remedies. Each Party acknowledges and
agrees that the other Party’s remedies at law for breach or threatened breach of any of the provisions of this Article 10 would be inadequate and, in recognition of that fact, in the event of any such breach or threatened breach, it is agreed
that, in addition to other remedies to which it may be entitled, the other Party will be entitled to equitable relief in the form of specific performance, temporary restraining order, temporary or permanent injunction without the necessity of
posting bond, or any other equitable remedy which may then be available; provided, that nothing herein contained will be construed as prohibiting the non-breaching Party from pursuing any other remedies available to it for such breach or threatened
breach, including recovery of damages from such breaching Party. 
 ARTICLE XI 

REPRESENTATIONS AND WARRANTIES 
 11.1. Representations and Warranties of Genomatica. Genomatica represents and warrants to Chemtex as of the Effective Date that: 

(a) Genomatica is a corporation, duly incorporated, validly existing and in good standing under the laws of the State of
Delaware. Genomatica has all requisite power and authority to carry on its business and to own and use the assets and properties owned and used by it. 
 (b) Genomatica has all requisite power and authority to execute and deliver this JDA and to perform its obligations hereunder. The execution and delivery of this JDA by Genomatica and the performance by
Genomatica of its obligations hereunder have been duly and validly authorized by all necessary action on the part of Genomatica. This JDA has been duly and validly executed and delivered by Genomatica and, assuming the due authorization, execution
and delivery by Chemtex, constitutes a valid and binding obligation of Genomatica enforceable against Genomatica in accordance with its terms. 
 (c) The execution and delivery of this JDA by Genomatica and the performance by Genomatica of its obligations hereunder, does not and will not, as the case may be, (i) conflict with or violate any
provision of the Certificate of Incorporation or the Bylaws of Genomatica, (ii) conflict with, result in a breach of, constitute (with or without due notice or lapse of time or both) a default under, result in the acceleration of, create in any
party the right to accelerate, terminate, modify or cancel, or require any notice, consent or waiver under, any contract, agreement or arrangement (written or oral), franchise or permit to which Genomatica is a party or by which Genomatica is bound,
(iii) result in the 

  
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imposition of any lien, claim, charge or encumbrance upon any Genomatica Intellectual Property, or (iv) violate any Law applicable to Genomatica. 

(d) There is no action, suit, proceeding, claim, or investigation pending or threatened against Genomatica, in any court
or by or before any governmental authority, or before any arbitrator of any kind, which, if adversely determined, would restrict the ability of Genomatica to perform its obligations hereunder. Genomatica knows of no basis for any such action, suit,
claim, investigation, or proceeding. 
 (e) Genomatica is the exclusive owner of the Background Intellectual
Property included in the Genomatica Intellectual Property, and it has the right to grant Chemtex the limited license under Section 9.1 without conflict with the rights of any Third Party, or has secured all necessary and appropriate consents to
license the same. 
 (f) The Background Intellectual Property included in the Genomatica Intellectual Property is
not subject to any claims, encumbrances, liens, licenses, judgments and/or security interests that could reasonably be expected to have an adverse effect on the right to practice such Background Intellectual Property in the Bio-BDO Field, and none
of the Background Intellectual Property included in the Genomatica Intellectual Property is the current subject of any litigation, interference or opposition proceeding. 

(g) Genomatica is unaware of any publications or activities (including, without limitation, patents, articles, and public
uses or sales) by it or others, which could reasonably be expected to invalidate any claim(s) of any patent or patent application within the Background Intellectual Property included in the Genomatica Intellectual Property. 

(h) Genomatica is not aware of any valid Third Party Intellectual Property that could reasonably be expected to be
infringed or asserted to be infringed by practice of the Background Intellectual Property included in the Genomatica Intellectual Property in the performance of the Joint Development Program pursuant to this JDA. 

(i) Genomatica has and will continue to have the legal power to extend the rights granted to Chemtex in this JDA with
respect to Process Intellectual Property and JDA Intellectual Property owned by Genomatica, and it has not made and will not make any commitments to others inconsistent with or in derogation of such rights. 

(j) Genomatica has, and will through the term of this JDA, cause its employees who work on the Joint Development Program
to disclose to it inventions within the scope of JDA Intellectual Property or Process Intellectual Property and to assign to it rights in such inventions, it being understood that if 

  
 15 

 
due care and diligence are used, any inadvertent failure to comply with this Section 11.1(j) will not constitute a breach of this JDA. 

11.2. Representations and Warranties of Chemtex. Chemtex represents and warrants to Genomatica as of the Effective Date that:

 (a) Chemtex is a corporation validly existing and in good standing under the laws of the country of Italy.
Chemtex has all requisite power and authority to carry on its business and to own and use the assets and properties owned and used by it. 
 (b) Chemtex has all requisite power and authority to execute and deliver this JDA and to perform its obligations hereunder. The execution and delivery of this JDA by Chemtex and the performance by Chemtex
of its obligations hereunder have been duly and validly authorized by all necessary action on the part of Chemtex. This JDA has been duly and validly executed and delivered by Chemtex and, assuming the due authorization, execution and delivery by
Genomatica, constitutes a valid and binding obligation of Chemtex enforceable against Chemtex in accordance with its terms. 
 (c) The execution and delivery of this JDA by Chemtex and the performance by Chemtex of its obligations hereunder, does not and will not, as the case may be, (i) conflict with or violate any
provision of the Certificate of Incorporation or By-Laws of Chemtex, (ii) conflict with, result in a breach of, constitute (with or without due notice or lapse of time or both) a default under, result in the acceleration of, create in any party
the right to accelerate, terminate, modify or cancel, or require any notice, consent or waiver under, any contract, agreement or arrangement (written or oral), franchise or permit to which Chemtex is a party or by which Chemtex is bound,
(iii) result in the imposition of any lien, claim, charge or encumbrance upon any Chemtex Intellectual Property, or (iv) violate any Law applicable to Chemtex. 

(d) There is no action, suit, proceeding, or material claim or investigation pending or threatened against Chemtex, in any
court or by or before any governmental authority, or before any arbitrator of any kind, which, if adversely determined, would restrict Chemtex’s ability to perform its obligations hereunder. Chemtex knows of no basis for any such action, suit,
claim, investigation, or proceeding. 
 (e) Chemtex is the exclusive owner of the Background Intellectual
Property included in the Chemtex Intellectual Property, and it has the right to grant Genomatica the limited license under Section 9.1 without conflict with the rights of any Third Party, or has secured all necessary and appropriate consents to
license the same. 
 (f) The Background Intellectual Property included in the Chemtex Intellectual Property is
not subject to any claims, encumbrances, liens, licenses, 

  
 16 

 
judgments and/or security interests that could reasonably be expected to have an adverse effect on the right to practice such Background Intellectual Property in the Bio-BDO Field, and none of
the Background Intellectual Property included in the Chemtex Intellectual Property is the current subject of any litigation, interference or opposition proceeding. 

(g) Chemtex is unaware of any publications or activities (including, without limitation, patents, articles, and public
uses or sales) by it or others, which could reasonably be expected to invalidate any claim(s) of any patent or patent application within the Background Intellectual Property included in the Chemtex Intellectual Property. 

(h) Chemtex is not aware of any Third Party Intellectual Property that could reasonably be expected to be infringed or
asserted to be infringed by practice of the Background Intellectual Property included in the Chemtex Intellectual Property in the performance of the Joint Development Program pursuant to this JDA. 

(i) Chemtex has and will continue to have the legal power to extend the rights granted to Genomatica in this JDA with
respect to Chemtex Intellectual Property, PROESATM Intellectual Property and JDA Intellectual Property owned by Chemtex, and it has not made and will not make any commitments to others inconsistent with or in derogation of such rights.

 (j) Chemtex has, and will through the term of this JDA, cause its employees who work on the Joint Development
Program to disclose to it inventions within the scope of JDA Intellectual Property, PROESATM Intellectual Property or Process Intellectual Property and to assign to it rights in such inventions, it being understood that if due care and diligence
are used, any inadvertent failure to comply with this Section 11.2(j) will not constitute a breach of this JDA. 
 11.3.
Notice of Developments. The Parties will give prompt written notice to each other of (a) any event or development causing a breach of any of their respective representations and warranties contained in this JDA, (b) any failure to
comply with or satisfy any covenant or agreement to be complied with by such Party hereunder and (c) any event or development that, individually or in the aggregate, could reasonably be expected to result in a breach of any of their respective
representations and warranties contained in this JDA or the failure to comply with or satisfy any covenant or agreement to be complied with by such Party hereunder. No disclosure by any Party pursuant to this Section 11.3, however, shall be
deemed to prevent or cure any misrepresentation, breach of warranty or breach of covenant. During the term of this JDA, no Party shall take any action or agree to take any action, either orally or in writing, that could reasonably be expected to
result in a breach of any of their respective representations and warranties contained in this JDA or any failure to comply with or satisfy any covenant or agreement to be complied with by such Party hereunder. 

  
 17 

 11.4 DISCLAIMER OF WARRANTIES. Except as specifically provided in this Article XI,
each Party disclaims all warranties of any kind, express or implied, to the fullest extent permitted by Law, including but not limited to the implied warranties of merchantability, fitness for particular purpose and noninfringement. NEITHER PARTY
MAKES ANY REPRESENTATION OR WARRANTY WITH REGARD TO THE SUCCESS OF THE JOINT DEVELOPMENT PROGRAM OR THE USEFULNESS OF ANY BACKGROUND INTELLECTUAL PROPERTY, PROCESS INTELLECTUAL PROPERTY OR JDA INTELLECTUAL PROPERTY. 

ARTICLE XII 

INDEMNIFICATION 
 12.1. Indemnification by Genomatica. Genomatica shall indemnify, defend, and hold harmless Chemtex and its Representatives from and against any and all damages, losses, liabilities, judgments,
awards, costs, and expenses of any nature whatsoever, including reasonable attorneys’ fees and court costs (collectively, “Damages”), incurred by any of them as a result of (a) any Third Party claims, actions, suits or
proceedings arising from any breach of any representation, warranty, covenant or agreement of Genomatica herein or (b) any Third Party claims that the practice of the Background Intellectual Property included in the Genomatica Intellectual
Property in the performance of the Joint Development Program pursuant to this JDA infringes Intellectual Property of such Third Party. 
 12.2. Indemnification by Chemtex. Chemtex shall indemnify, defend, and hold harmless Genomatica and its Representatives from and against any and all Damages incurred by any of them as a result of
(a) any Third Party claims, actions, suits or proceedings arising from any breach of any representation, warranty, covenant or agreement of Chemtex herein or (b) any Third Party claims that the practice of the Background Intellectual
Property included in the Chemtex Intellectual Property in the performance of the Joint Development Program pursuant to this JDA infringes Intellectual Property of such Third Party. 

12.3. Control of Defense. Except as specifically provided in this section, any Person entitled to indemnification under this
Article XII shall give written notice to the indemnifying Party of any claims that may be subject to indemnification, promptly after learning of such claim, and the indemnifying Party shall assume the defense of such claims with counsel reasonably
satisfactory to the indemnified party. If such defense is assumed by the indemnifying Party with counsel so selected, the indemnifying Party will not be subject to any liability for any settlement of such claims made by the indemnified party without
its consent (but such consent will not be unreasonably withheld or delayed), and will not be obligated to pay the fees and expenses of any separate counsel retained by the indemnified party with respect to such claims. 

12.4. Remedies. No remedy set forth in this JDA is intended to be exclusive of any other remedy. Each remedy shall be in addition
to every other remedy provided hereunder, or now or hereafter existing at law, in equity, by statute, or otherwise. 

  
 18 

 ARTICLE XIII 
 TERM AND TERMINATION 
 13.1. Termination by the Parties. This JDA
may be terminated: 
 (a) by mutual written consent of Chemtex and Genomatica; 

(b) by Genomatica in the event Chemtex has breached in any material respect any representation, warranty, covenant or
agreement of Chemtex contained in this JDA, Genomatica has notified Chemtex of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach; 

(c) by Chemtex in the event Genomatica has breached in any material respect any representation, warranty, covenant or
agreement of Genomatica contained in this JDA, Chemtex has notified Genomatica of the breach, and the breach has continued without cure for a period of thirty (30) days after the notice of breach; 

Any termination of this JDA pursuant to Section 13.1 shall be effective upon the delivery of written notice of the terminating Party to the other
Party. 
 13.2. Automatic Termination. This JDA shall automatically terminate, unless the Parties agree otherwise, upon:

 (a) the mutual decision by the Parties to discontinue the Joint Development Program; 

(b) the expiration of five years from the Effective Date; or 

(c) the date on which Genomatica enters into a Third Party Agreement. 

13.3. Effect of Termination. Upon termination of this JDA pursuant to this Article XIII all rights and obligations of the Parties
under this JDA shall terminate, except as provided in this Section 13.3. Upon termination of this JDA, Genomatica shall have the right to remove at its cost any equipment or materials that it has supplied or paid for pursuant to
Section 7.2 hereof, provided that it elects to exercise that right within 60 days after the date of termination. Termination of this JDA shall not relieve or release either Party of any right or obligation which, at the time of such
termination, has already accrued to such Party or which is attributable to a period prior to such termination, nor will any expiration or termination of this JDA preclude either Party from pursuing all rights and remedies it may have under this JDA,
at law or in equity, with respect to breach of this JDA. The provisions set forth in Sections 9.2, 9.3, 9.4, 11.4 and 13.3 and Articles I, VIII, X, XII and XIV shall remain in full force and effect and survive any termination of this JDA. The
expiration or termination of this JDA shall not affect any PROESATM License Agreement entered into prior to such expiration or termination, which shall remain in effect in accordance with its terms. 

  
 19 

 ARTICLE XIV 
 GENERAL TERMS 
 14.1. Non-Solicitation. During the term of this JDA
and for a period of [...***...] after the termination of this JDA, unless otherwise agreed to by the Parties, each Party agrees that it will not and will not permit its Affiliates to directly or indirectly solicit for employment or consulting
any employee of the other Party or its Affiliates; provided that in no event will listing or advertising any employee or consultant position in any publicly available source or hiring or engaging any person who contacts a Party or its Affiliate
based upon such listing or advertisement be a breach of this Section 14.1. 
 14.2. Force Majeure. The Parties shall
be exempt from liability in respect of any failure to perform their obligations under this JDA due to circumstances beyond their reasonable control, including but not limited to those arising from: (i) war, acts of terrorism, fire, epidemic,
flood or other acts of God, explosion, civil commotion, strike, lock-out or labor disturbances, acts, regulations or laws of any government, or failure of public utilities or common carriers, (ii) inability to procure raw materials due to
shortages of raw materials, or (iii) prevention from or hindrance in obtaining energy or other utilities. The Party so affected shall give written notice to the other Party of any such force majeure event and shall use its good faith efforts to
avoid or remove such causes of non-performance and to continue performance whenever such causes are removed. Should the event(s) of force majeure suffered by a Party extend beyond a three (3)-month period, the other Party may then terminate this JDA
by written notice to the non-performing Party, with the consequences of such termination as set forth in Section 13.3. 

14.3. Notices. Except as expressly set forth to the contrary in this JDA, all notices, requests, or consents provided for
or permitted to be given under this JDA must be in writing and must be given either by depositing that writing in the United States mail, addressed to the recipient, postage paid, and registered or certified with return receipt requested or by
delivering that writing to the recipient in person, by courier, or by facsimile transmission; and a notice, request, or consent given under this JDA is effective on receipt by the person to receive it. All notices, requests, and consents to be sent
to a Party must be sent to or made at the following addresses (or such other address as that a Party may specify by notice to the other Party). 
  

			
	 If to Chemtex:
	  	Chemtex Italia S.r.l.
		  	Strada Ribrocca n. 11
		  	15057 Tortona (AL) Italy
		  	Attention: Corporate R&D Director
		  	Facsimile: (39) 0131-81-1759

  

					
		  	20	  	***Confidential Treatment Requested

			
	 with a copy to:
	  	Chemtex International Inc.
		  	1979 Eastwood Road
		  	Wilmington, NC 28403
		  	Attention: General Counsel
		  	Facsimile: (910) 509-4567
		
	 If to Genomatica, to:
	  	Genomatica, Inc.
		  	10520 Wateridge Circle
		  	San Diego, CA 92121
		  	Attention:    Chief Technology Officer
		  	Facsimile:    (858) 824-1772
		
	 with a copy to:
	  	Cooley LLP
		  	4401 Eastgate Mall
		  	San Diego, CA 92121
		  	Attention: Kay Chandler
		  	Facsimile: (858) 550-6420

 Whenever any notice is required to be given by law or this JDA, a written waiver thereof, signed by the person entitled
to notice, whether before or after the time stated therein, shall be deemed equivalent to the giving of such notice. 
 14.4.
Entire Agreement; Superseded. This JDA, together with the Exhibits hereto and the MOU and, as applicable, the PROESATM License Agreement, constitutes the entire agreement of the Parties relating to the subject matter hereof and thereof
and supersedes all prior contracts or agreements with respect to the development of a process for Bio-BDO, whether oral or written, including the NDA. 
 14.5. Effect of Waiver or Consent. A waiver or consent, express or implied, to or of any breach or default by any Party in the performance by that Party of its obligations is not a consent or
waiver to or of any other breach or default in the performance by that Party of the same or any other obligations of that Party. Failure on the part of a Party to complain of any act of any Party or to declare the other Party in default,
irrespective of how long that failure continues, does not constitute a waiver by that Party of its rights with respect to that default until the applicable statute-of-limitations period has run. 

14.6. Amendment or Modification. This JDA may be amended, modified, or supplemented only by a written instrument duly executed by
each of the Parties to, which instrument shall specifically indicate that it is the desire of the Parties to amend, modify or supplement this JDA, and similarly may be waived only by a written instrument duly executed by the waiving Party.

 14.7. Binding Act. This JDA is binding on and inures to the benefit of the Parties and their respective heirs,
legal representatives, successors, and assigns. 

  
 21 

 14.8. Governing Law. THIS JDA IS GOVERNED BY AND SHALL BE CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF DELAWARE, EXCLUDING ANY CONFLICT-OF-LAWS RULE OR PRINCIPLE THAT MIGHT REFER THE GOVERNANCE OR THE CONSTRUCTION OF THIS JDA TO THE LAW OF ANOTHER JURISDICTION. 

14.9. Severability. If any provision of this JDA or the application thereof to any person or circumstance is held invalid or
unenforceable to any extent, the remainder of this JDA and the application of that provision to other persons or circumstances is not affected thereby and that provision shall be enforced to the greatest extent permitted by Law. 

14.10. Further Assurances. In connection with this JDA and the transactions contemplated hereby, each Party shall execute and
deliver any additional documents and instruments and perform any additional acts that may be necessary or appropriate to effectuate and perform the provisions of this JDA and those transactions. 

14.11. No Third Party Beneficiaries. The provisions hereof are solely for the benefit of the Parties and are not intended to, and
shall not be construed to, confer a right or benefit on any other person. 
 14.12. Counterparts. This JDA may be
executed in any number of counterparts with the same effect as if all signing Parties had signed the same document. All counterparts shall be construed together and constitute the same instrument. 

14.13. Assignability. Unless expressly provided otherwise in this JDA, no Party shall have the right to assign or otherwise
transfer its rights or obligations under this JDA, except with the written consent of the other Party, not to be unreasonably withheld or delayed; provided, however, that a Party may, without the other Party’s consent, assign or otherwise
transfer its rights or obligations under this JDA to (a) a successor in interest to all or substantially all of the business of such Party to which this JDA relates, whether by merger, sale of stock, sale of assets or otherwise, or
(ii) any Affiliate. In the event of any assignment of this JDA by a Party to its Affiliate pursuant to this Section 14.13, the assigning Party shall remain liable and responsible to the non-assigning Party hereto for the performance and
observance of all such rights and obligations by such Affiliate. Any assignment of this JDA in contravention of this Section 14.13 shall be null and void. 
 14.14. Resolutions of Disputes. 
 (a) The Parties will use
commercially reasonable efforts to resolve any dispute through good faith negotiations. If within [...***...] of any dispute being notified to the other Party the dispute has not been satisfactorily concluded, then unless otherwise agreed, the
Parties shall refer the dispute to the Chief Executive Officer of Chemtex and the Chief Executive Officer of Genomatica. If within [...***...] of the dispute being referred to the individuals referenced in the prior sentence the dispute has
not been 

  

					
		  	22	  	***Confidential Treatment Requested

 
satisfactorily concluded, then either Party may (but is not required to) refer the dispute for resolution 
pursuant to Section 14.14(b). 
 (b) Following negotiations pursuant to Section 14.14(a), any
remaining dispute, controversy, or claim arising under, out of or relating to this JDA (and subsequent amendments thereof), its validity, binding effect, interpretation, performance, breach or termination, including tort claims, shall be finally
determined by arbitration administered by the American Arbitration Association under its Commercial Arbitration Rules, as in force at the time when the arbitration is initiated. The arbitral tribunal shall consist of three (3) mutually
acceptable arbitrators. The place of arbitration shall be [...***...]. Judgment on the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. 

14.15. Headings and Recitals. The headings and recitals used herein are for ease of reference and information and do not affect
the interpretation of the Article to which they relate or the interpretation of this JDA in any other respect. 
 14.16.
Limitation of Liability. IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER OR ITS AFFILIATES FOR ANY SPECIAL OR CONSEQUENTIAL DAMAGES, REGARDLESS OF THE FORM OF ACTION, WHETHER IN CONTRACT, IN TORT INCLUDING NEGLIGENCE, BY STATUTE OR
UNDER ANY QUASI-CONTRACTUAL THEORY OF LIABILITY, EVEN IF A PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. The foregoing limitations of liability and damages will not apply and nothing in this JDA shall affect either Party’s
liability for breach of any obligation specified in Article X or either Party’s indemnification obligations under Article XII. 
 [signature page follows] 

  

					
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 IN WITNESS WHEREOF, the Parties caused this Joint Development Agreement to be executed by
their duly authorized and empowered representatives as of the Effective Date. 
  

	
	CHEMTEX ITALIA S.R.L.
	
	 By: /s/ Illegible

	
	 Title: Chief Technology Officer

	
	GENOMATICA, INC.
	
	 By: /s/ William Baum

	
	 Title: Executive Chairman

  

SIGNATURE PAGE TO JOINT DEVELOPMENT AGREEMENT

 SCHEDULE 1.2.12 

DEVELOPMENT PLAN 
  

	 	1.	Definition of the [...***...] 

  

	 	2.	Delivery of [...***...] 

  

	 	3.	Definition of [...***...] 

  

	 	4.	Definition of [...***...] 

  

	 	5.	APPROVAL OF [...***...] 

  

	 	6.	Execution of [...***...] 

  

	 	7.	Start up of the plant 

  

	 	8.	Operation of the pilot plant. 

  

	 	9.	[...***...] 

 During operation the
following aspect will be tested: 
 [...***...] 
 TIMING: 
 [...***...] 
 Commercialization KPIs 
 Overall process that [...***...] 

Quality: [...***...] 

  

					
		  		  	***Confidential Treatment Requested

 Schedule 1.2.16 

GENOMATICA MICROORGANISMS 
 [...***...] 

  
 1 

 SCHEDULE 1.2.32 

MOU 

Biomass to Chemicals Partnership 
 Memorandum of Understanding (MOU) 
 (Non-Binding) 

February 14, 2011 
  

 
  

					
	 

	 		  	

  
  

The purpose of the MOU is to set forth the basis for a series of Agreements establishing a partnership between Gruppo M&G and Genomatica for the
development and commercialization of process technologies to produce major basic and intermediate chemicals from biomass. This MOU is intended by the parties to be non-binding, does not contain all of the terms necessary to effect the transactions
contemplated hereby, and if the parties wish to proceed with the transaction, the terms of any such agreements effecting the transaction shall be embodied in a definitive agreement or agreements. 

  
 1 

 [...***...] 
 Gruppo M&G and Genomatica seek to enter into a partnership that will lead the way for commercial production of major industrial chemicals from biomass, [...***...] Together the companies will
[...***...] enabling the conversion of cellulosic biomass into major industrial chemicals, [...***...] The partnership will begin in Q2’11 with a focus on 1,4-butanediol (BDO) [...***...]. In addition the parties may enter
into a third aspect of the partnership to pursue the production of [...***...]. 
  

	 	1.	Gruppo M&G Background 

Gruppo M&G is privately held company in Italy owned by the Ghisolfi family with [...***...] (“PROESATM technology”). Chemtex is currently building a 45KT cellulosic
ethanol facility in Crescentino, Italy [...***...]. 
  

	 	2.	Genomatica Background 

 Genomatica is a
privately-held venture capital backed company in the US. Genomatica aims to become the leading sustainable chemicals company in the world in terms of both the production of sustainable chemicals as well as the development of innovative process

  

					
		  	2	  	***Confidential Treatment Requested

 
technologies to convert renewable feedstocks into chemicals. Genomatica has developed a novel bioprocess that offers the first low-cost direct route for the production of renewable BDO. This
process will deliver a cost-advantage versus the current production of BDO from hydrocarbon feedstocks. Genomatica is currently driving initial commercial production of Bio-BDO from dextrose in the US to demonstrate the process at commercial scale
targeting initial production from an integrated facility by the end of 2013, with possible toll manufacturing of the first Bio-BDO in 2012. In addition Genomatica has established intellectual property that forms the basis of other bioprocesses
targeting 20+ basic and intermediate chemicals, and seeks to develop processes for many of these chemicals including [...***...]. 
  

	 	3.	Scope 

 [...***...]: 

 

	 	1.	 Development and Commercialization of Biomass to BDO – In the coming months Genomatica and Chemtex will aim to establish a joint development
agreement to develop the complete biomanufacturing process for making BDO from cellulosic biomass (2G-BDO,
2nd generation BDO process), and drive a path for the
initial commercialization in [...***...]. 

 [...***...]. 

  

					
		  	3	  	***Confidential Treatment Requested

 [...***...] 

 

	 	4.	Development and Commercialization of Biomass to BDO 

 [...***...] 
 It is the desire of M&G/Chemtex and Genomatica to coordinate on impactful
public announcements around the partnership for biomass to chemicals. 
 [...***...] 

  

					
		  	4	  	***Confidential Treatment Requested

 Chemtex-Genomatica Exclusive Joint Development Agreement for Biomass to BDO 

Genomatica and Chemtex will form an exclusive partnership to develop and license a commercial process for biomass to BDO integrating
PROESATM technology with Genomatica BDO fermentation
technology and relevant needed separation technology. (2G-BDO) 
 [...***...] 

Genomatica’s current BDO process will [...***...] use biomass feedstock derived from the Chemtex PROESA technology. The combined process will
then be demonstrated at approximately a 1 ton/day of biomass scale in an integrated demonstration plant that will be operational in H1’12 that will be similar to the existing pilot plant in Rivalta that has been the basis for generating the
basic engineering package for the current commercial cellulosic ethanol facility being constructed in Crescentino. 

[...***...] 
  

  

					
		  	5	  	***Confidential Treatment Requested

 [...***...] 
  

  

					
		  	6	  	***Confidential Treatment Requested

 M&G-Chemtex-Genomatica Commercial Agreement for Biomass to BDO 

Genomatica and M&G will agree to engage in exploring the first commercial plant for producing BDO from biomass. Genomatica will drive the
commercialization as part of its BDO business, and M&G (directly or through a nominated third party) will at a minimum provide guaranteed off-take of a certain quantity of BDO for [...***...]. Initial commercialization will target
[...***...]. Initial estimated capacity is 20-45KT. 
 [...***...] 

 

  

					
		  	7	  	***Confidential Treatment Requested

 [...***...] 
 As part of this partnership, Genomatica and M&G will enter into a Sponsored Research Agreement that will begin in [...***...]. 

[...***...] 
  

  

					
		  	8	  	***Confidential Treatment Requested

 [...***...] 

 

			
	GRUPPO M&G	  	GENOMATICA, INC.
		
	 Signature:
                                        
            
	  	Signature:                           
                                 
		
	 Name:
                                        
                  
	  	Name:                            
                                      
		
	 Title:
                                        
                    
	  	Title:                            
                                        

		
	 Date:
                                        
                    
	  	Date:                            
                                        

  

					
		  	9	  	***Confidential Treatment Requested

 SCHEDULE 3.1(a) 

RESPONSIBILITY OF PARTIES FOR EXPENSES 
  

			
	 ITEM
	  	 Responsibility

	 Genomatica Personnel cost and travelling expenses both in Genomatica lab and in Chemtex Lab
	  	[...***...]
	 Chemtex Personnel cost and travelling expenses both in Genomatica lab and in Chemtex Lab
	  	[...***...]
	 Cost of biomass feedstock for testing and running pilot plant
	  	[...***...]
	 Equipment, instrumentation and installation cost needed to modify the pilot line in order to produce 2G-BDO
	  	[...***...]
	 Cost of BDO disposal if not used for testing
	  	[...***...]
	 Cost of preparation of PDP
	  	[...***...]
	 All activities for product storage, testing
	  	[...***...]
	 Sample delivery
	  	[...***...]

  

					
		  	1	  	***Confidential Treatment Requested

 Schedule 4.1 
 BDO Specification 
 [...***...] 

 

  

					
		  	1	  	***Confidential Treatment Requested

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