Document:

AMENDMENT NUMBER 1
                             to the October 14, 2002
               AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

      This Amendment Number 1 to the October 14, 2002 Amended and Restated
Registration Rights Agreement (the "Agreement"), made effective as of September
29, 2007, is by and between the Holders and BioForce Nanosciences Holdings, Inc.
(the "Company"), as successor to BioForce Nanosciences, Inc.

      WHEREAS, the Holders possess certain registration rights as parties to the
October 14, 2002 Amended and Restated Registration Rights Agreement (the "Prior
Amendment");

      WHEREAS, under Section 2(a) of the Prior Amendment the Holders may request
that their shares be included in a registration if the Company proposes to
register any shares of its capital stock under the Securities Act;

      WHEREAS, as required by Section 2(a) of the Prior Agreement the Company
provided notice to the Holders of the Company's intent to file on or about
October 1, 2007 a registration statement under the Securities Act (the "Current
Registration") for shares of its capital stock owned by certain institutional
investors ("Institutional Investors"); and

      WHEREAS, the Company has requested that the Holders enter into this
Agreement whereby they would agree to amend the Prior Amendment, waiving their
registration rights associated with the Current Registration in exchange for the
right to be included in a certain subsequent registration as explained more
fully below.

      NOW, THEREFORE, in consideration of the premises, the mutual agreements
herein set forth below and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows:

1. Until the earlier to occur of (a) six months after the registration statement
filed by the Company with the United States Securities and Exchange Commission
(the "SEC") in connection with the Current Registration is deemed effective by
the SEC or (b) such registration statement is withdrawn by the Company and not
promptly refiled, the Holders agree not to exercise any rights they have under
the Prior Amendment to request registration of their Registrable Shares except
as provided below.

2. If the Company is required to file more than one registration statement to
register the shares contemplated by the Current Registration, the Company agrees
to include in the subsequent filing as many of the Registrable Shares and any
other shares owned by Holders as of September 24, 2007 ("Additional Shares")
(collectively, "Holder Shares") as Holders indicate in writing that they desire
registered at that time.

<PAGE>

3. If a registration statement including Holder Shares is filed under Section 2,
and less than all of the Holder Shares are registered under Section 2, the
Company agrees to file one or more registration statements for the Holders until
the Holder Shares are registered, subject to the minimum number of shares to be
registered being greater than 500,000.

4. If no registration statement including Holder Shares is filed under Section
2, the Company agrees to file a registration statement for the Holders,
including in the registration statement as many of the Holder Shares as the
Holders indicate in writing that they desire registered at that time. If less
than all of the Holder Shares are registered as a result of this filing, the
Company agrees to promptly file subsequent registration statements until all of
the Holder Shares that have been requested to be registered are registered. In
either case, the Company shall have no obligation to file a registration
statement if the number of Holder Shares to be included in the registration is
less than 500,000. The Company shall file the initial registration statement
under this Section no later than seven months following the date on which all of
the shares contemplated by the initial registration statement for the Current
Registration are registered or that registration statement is withdrawn and not
promptly refiled, but in any event no later than nine (9) months from the date
hereof. This nine-month time period shall be subject to automatic extensions for
any time after two (2) months from the date hereof that the Company is
diligently pursuing with the SEC the effectiveness of the initial registration
statement associated with the Current Registration.

5. The following shall determine the order of precedence for including shares in
a registration statement under this Agreement: the shares owned by the
Institutional Investors; followed by the Registrable Shares owned by all
Holders; followed by the Additional Shares owned by all Holders (the "Priority
Requirements").

6. In the event any Registrable Shares remain to be registered after exhaustion
of Section 3 or 4, their registration shall be governed by the Prior Amendment.
The Additional Shares shall have no further registration rights.

7. This Amendment shall be binding upon and inure to the benefit of the parties
hereto and their respective successors, heirs and assigns.

8. Each party warrants and represents that the person signing this Agreement has
the full and proper authority to do so and has been empowered to make and
execute this Agreement in the name of such party.

9. This Agreement may be executed in any number of counterparts, each of which
shall be deemed to be an original, and all of which taken together shall
constitute one and the same Agreement.

10. All capitalized terms used in the Agreement not otherwise defined herein
shall have the same meaning as in the Prior Amendment. All terms of the Prior
Amendment shall continue in full force and effect except as expressly modified
by this Agreement. All terms of the Prior Amendment shall apply to this
Agreement, including, without limitation, to the registration statement(s)
covering the Holders Shares contemplated hereby, except in the event and to the
extent they are expressly modified herein, in which case the terms of this
Agreement shall control.

                                       2
<PAGE>

11. This Agreement shall become binding upon the Company and all Holders of
Registrable Shares upon its execution by the Holders of at least 51% of the
Registrable Shares.

BioForce Nanosciences Holdings, Inc.

By:
    --------------------------------
Name:
Title:

HOLDER:

By:
    --------------------------------
Name:
Title:

                                       3Mr. Mike Dunham
c/o WorkWise, Inc.
12000 W. Park Place
Milwaukee WI 53224-3026
USA

                                                                 August 21, 2007

Dear Mike,

It is my pleasure to offer you a seat on the Board of Directors for BioForce
Nanosciences Holdings, Inc. The Board meets four times per year, with at least
one (preferably two) meetings being held in person. I believe we can accommodate
your annual travel schedule and living arrangements by having physical meetings
of the board at the appropriate times and places.

Board members are currently compensated with options to purchase BioForce stock
at pricing that is determined by the market price at the time of issuance. You
will receive 200,000 options to purchase BioForce stock, vesting over a
three-year period as follows.

66,666 after the first year of service
66,666 after the second year of service
66,667 after the third year of service

All options would vest immediately upon a change in control.

BioForce does not currently provide cash compensation to our Directors. However
I would like to change that policy and will bring the matter forward in an
upcoming Board meeting. I will propose a reasonable level of additional cash
compensation for service as a board committee chair. Such committees have not
yet been established, but I believe that that deficit must be rectified quickly.
In particular, we need to establish an audit committee, and I consider you to be
the best candidate for chair of that committee if that service can be melded
with your other activities.

Thank you for your kind consideration. Please feel free to contact Greg, Kerry
or me if you have any questions or comments.

Best wishes,

/s/ Eric Henderson
---------------------------
Eric Henderson, CEO
BioForce Nanosciences, Inc.
Ames, IA 50014

515 233 8333 x101
ehenderson@bioforcenano.comAGREEMENT AND PLAN OF MERGER

         This AGREEMENT AND PLAN OF MERGER (hereinafter called this
"Agreement"), dated as of August 27, 2007, is entered into between Discovery
Technologies, Inc., a Nevada corporation (the "Discovery Technologies Nevada")
and Discovery Technologies, Inc., a Kansas corporation (the "Company")

         RECITALS

         WHEREAS, the board of directors of each of Discovery Technologies
Nevada and the Company deems it advisable, upon the terms and subject to the
conditions herein stated, that the Company be merged with and into Discovery
Technologies Nevada, and that Discovery Technologies Nevada be the surviving
corporation (the "Reincorporation Merger"); and

         WHEREAS, the Company will submit this Agreement for approval by
separate vote of the holders of shares of common stock, no par value, of the
Company ("common stock") at a special meeting.

         NOW, THEREFORE, in consideration of the premises and of the agreements
of the parties hereto contained herein, the parties hereto agree as follows:

                                    ARTICLE I

                   THE REINCORPORATION MERGER; EFFECTIVE TIME

         1.1. The Reincorporation Merger. Upon the terms and subject to the
conditions set forth in this Agreement, at the Effective Time (as defined in
Section 1.2), the Company shall be merged with and into Discovery Technologies
Nevada, whereupon the separate existence of the Company shall cease. Discovery
Technologies Nevada shall be the surviving corporation (sometimes hereinafter
referred to as the "Surviving Corporation") in the Reincorporation Merger and
shall continue to be governed by the laws of the State of Nevada. The
Reincorporation Merger shall have the effects specified in the Kansas General
Corporation Code of the State of Kansas as amended (the "KGCC") and in the
Nevada Revised Statutes as amended (the "NRS") and the Surviving Corporation
shall succeed, without other transfer, to all of the assets and property
(whether real, personal or mixed), rights, privileges, franchises, immunities
and powers of the Company, and shall assume and be subject to all of the duties,
liabilities, obligations and restrictions of every kind and description of the
Company, including, without limitation, all outstanding indebtedness of the
Company.

         1.2. Effective Time. Provided that the condition set forth in Section
5.1 has been fulfilled or waived in accordance with this Agreement and that this
Agreement has not been terminated or abandoned pursuant to Section 6.1, on the
date of the closing of the Reincorporation Merger, the Company and Discovery
Technologies Nevada shall cause Articles of Merger to be executed and filed with
the Secretary of State of Nevada (the "Nevada Articles of Merger") and a
Articles of Merger to be executed and filed with the Secretary of State of
Kansas (the "Kansas Articles of Merger") . The Reincorporation Merger shall
become effective upon the date and time specified in the Nevada Articles of
Merger and the Kansas Articles of Merger (the "Effective Time")

<PAGE>

                                   ARTICLE II

                 CHARTER AND BYLAWS OF THE SURVIVING CORPORATION

         2.1. The Certificate of Incorporation. The certificate of incorporation
of Discovery Technologies Nevada in effect at the Effective Time shall be the
certificate of incorporation of the Surviving Corporation, until amended in
accordance with the provisions provided therein or applicable law.

         2.2. The Bylaws. The bylaws of Discovery Technologies Nevada in effect
at the Effective Time shall be the bylaws of the Surviving Corporation, until
amended in accordance with the provisions provided therein or applicable law.

                                   ARTICLE III

               OFFICERS AND DIRECTORS OF THE SURVIVING CORPORATION

         3.1. Officers. The officers of the Company at the Effective Time shall,
from and after the Effective Time, be the officers of the Surviving Corporation,
until their successors have been duly elected or appointed and qualified or
until their earlier death, resignation or removal.

         3.2. Directors. The directors of the Company at the Effective Time
shall, from and after the Effective Time, be the directors of the Surviving
Corporation, until their successors have been duly elected or appointed and
qualified or until their earlier death, resignation or removal.

                                   ARTICLE IV

                        EFFECT OF MERGER ON CAPITAL STOCK

         4.1. Effect of Merger on Capital Stock. At the Effective Time, as a
result of the  Reincorporation  Merger and without any action on the part of the
Company, Discovery Technologies Nevada or the shareholders of the Company:

         (a) Each share of common stock (other than shares ("Dissenting Shares")
that are owned by shareholders ("Dissenting Shareholders") exercising
dissenters' rights pursuant to Section 17-6712 of the KGCC), issued and
outstanding immediately prior to the Effective Time shall be converted at a
ratio of nine (9) shares of common stock, no par value, for one (1) share of
Discovery Technologies Nevada Common Stock, par value $.01, ("Nevada Common
Stock"), with the same rights, powers and privileges as the shares so converted
and all shares of common stock shall be cancelled and retired and shall cease to
exist. No fractional shares will be issued and all Nevada Common Stock ownership
will be rounded to the nearest full share.

         (b) Each option, warrant or other security of the Company issued and
outstanding immediately prior to the Effective Time shall be (i) converted into
and shall be an identical security of Discovery Technologies Nevada at the ratio
of nine (9) shares of common stock for one (1) share of Nevada Common Stock and

<PAGE>

(ii) in the case of securities to acquire common stock, converted into the right
to acquire shares of Nevada Common Stock on the same terms and at the same ratio
as the common stock of the Company are converted into Nevada Common Stock, and
at a price equal to nine (9) times the current exercise price. The same number
of shares of Nevada common stock shall be reserved for purposes of the exercise
of such options, warrants or other securities as is equal to the number of
shares of the common stock so reserved as of the Effective Time.

         (c) Each share of Nevada common stock owned by the Company shall no
longer be outstanding and shall be cancelled and retired and shall cease to
exist.

         4.2. Certificates. At and after the Effective Time, all of the
outstanding certificates which immediately prior thereto represented shares of
common stock (other than Dissenting Shares), options, warrants or other
securities of the Company shall be deemed for all purposes to evidence ownership
of and to represent the shares of the respective Nevada common stock, options,
warrants or other securities of Discovery Technologies Nevada, as the case may
be, into which the shares of common stock, options, warrants or other securities
of the Company represented by such certificates have been converted as herein
provided and shall be so registered on the books and records of the Surviving
Corporation or its transfer agent. The registered owner of any such outstanding
certificate shall, until such certificate shall have been surrendered for
transfer or otherwise accounted for to the Surviving Corporation or its transfer
agent, have and be entitled to exercise any voting and other rights with respect
to, and to receive any dividends and other distributions upon, the shares of
Nevada Common Stock, options, warrants or other securities of Discovery
Technologies Nevada, as the case may be, evidenced by such outstanding
certificate, as above provided.

         Further, as soon as practicable after the Effective Date, Corporate
Stock Transfer, Inc. will send shareholders, who hold all of their shares in
certificate form, a letter of transmittal. The letter of transmittal will
contain instructions on how to surrender your certificate(s) representing the
shares of common stock of the Company owned by you to the transfer agent. Upon
receipt of such shareholder's certificate, subject to the aforementioned ratio
of nine (9) shares of common stock of the Company for one (1) share of Nevada
Common Stock, such shareholder will be issued a new stock certificate for shares
of Nevada Common Stock.

         4.3. Dissenters' Rights. No Dissenting Shareholder shall be entitled to
shares of Nevada Common Stock under this Article IV unless and until the holder
thereof shall have failed to perfect or shall have effectively withdrawn or lost
such holder's right to dissent from the Reincorporation Merger under the KGCC,
and any Dissenting Shareholder shall be entitled to receive only the payment
provided by Section 17-6712 with respect to Dissenting Shares owned by such
Dissenting Shareholder. If any person or entity who otherwise would be deemed a
Dissenting Shareholder shall have failed to properly perfect or shall have
effectively withdrawn or lost the right to dissent with respect to any shares
which would be Dissenting Shares but for that failure to perfect or withdrawal
or loss of the right to dissent, such Dissenting Shares shall thereupon be
treated as though such Dissenting Shares had been converted into shares of
Nevada Common Stock pursuant to Section 4.1 hereof.

<PAGE>

                                    ARTICLE V

                                    CONDITION

         5.1. Condition to Each Party's Obligation to Effect the Reincorporation
Merger. The respective obligation of each party hereto to effect the
Reincorporation Merger is subject to receipt prior to the Effective Time of the
requisite approval of this Agreement and the transactions contemplated hereby by
the holders of common stock pursuant to the KGCC and the Articles of
Incorporation of the Company.

                                   ARTICLE VI

                                   TERMINATION

         6.1. Termination. This Agreement may be terminated, and the
Reincorporation Merger may be abandoned, at any time prior to the Effective
Time, whether before or after approval of this Agreement by the shareholders of
the Company, if the board of directors of the Company determines for any reason,
in its sole judgment and discretion, that the consummation of the
Reincorporation Merger would be inadvisable or not in the best interests of the
Company and its shareholders. In the event of the termination and abandonment of
this Agreement, this Agreement shall become null and void and have no effect,
without any liability on the part of either the Company or Discovery
Technologies Nevada or any of their respective shareholders, directors or
officers.

                                   ARTICLE VII

                            MISCELLANEOUS AND GENERAL

         7.1. Modification or Amendment. Subject to the provisions of applicable
law, at any time prior to the Effective Time, the parties hereto may modify or
amend this Agreement; provided, however, that an amendment made subsequent to
the approval of this Agreement by the holders of common stock shall not (i)
alter or change the amount or kind of shares and/or rights to be received in
exchange for or on conversion of all or any of the shares or any class or series
thereof of such corporation, (ii) alter or change any provision of the
certificate of incorporation of the Surviving Corporation to be effected by the
Reincorporation Merger, or (iii) alter or change any of the terms or conditions
of this Agreement it such alteration or change would adversely affect the
holders of any class or series of capital stock of any of the parties hereto.

         7.2. Counterparts. This Agreement may be executed in any number of
counterparts, each such counterpart being deemed to be an original instrument,
and all such counterparts shall together constitute the same agreement.

         7.3. GOVERNING LAW. THIS AGREEMENT SHALL BE DEEMED TO BE MADE IN AND IN
ALL RESPECTS SHALL BE INTERPRETED, CONSTRUED AND GOVERNED BY AND IN ACCORDANCE
WITH THE LAW OF THE STATE OF NEVADA WITHOUT REGARD TO THE CONFLICT OF LAW
PRINCIPLES THEREOF.

<PAGE>

         7.4. Entire Agreement. This Agreement constitutes the entire agreement
and supersedes all other prior agreements, understandings, representations and
warranties, both written and oral, among the parties, with respect to the
subject matter hereof.

         7.5. No Third Party  Beneficiaries.  This  Agreement is not intended to
confer upon any person other than the parties hereto any rights or remedies
hereunder.

         7.6. Severability. The provisions of this Agreement shall be deemed
severable and the invalidity or unenforceability of any provision shall not
affect the validity or enforceability of the other provisions hereof. If any
provision of this Agreement, or the application thereof to any person or any
circumstance, is determined by any court or other authority of competent
jurisdiction to be invalid or unenforceable, (a) a suitable and equitable
provision shall be substituted thereof or in order to carry out, so far as may
be valid and enforceable, the intent and purpose of such invalid or
unenforceable provision and (b) the remainder of this Agreement and the
application of such provision to other persons or circumstances shall not be
affected by such invalidity or unenforceability, nor shall such invalidity or
unenforceability affect the validity or enforceability of such provision, or the
application thereof, in any other jurisdiction.

         7.7. Headings. The headings therein are for convenience of reference
only, do not constitute part of this Agreement and shall not be deemed to limit
or otherwise affect any of the provisions hereof.

         IN WITNESS WHEREOF, this Agreement has been duly executed and delivered
by the duly authorized officers of the parties hereto as of the date first
written above.

                                             Discovery Technologies, Inc.
                                             a Nevada corporation

                                             By /s/ Michael Friess
                                             Name:   Michael Friess,
                                             Title:  Chief Executive Officer

                                             Discovery Technologies, Inc.
                                             a Kansas corporation

                                             By /s/ Michael Friess
                                             Name:   Michael Friess
                                             Title:  Chief Executive Officer

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