Document:

exv4w68

 

    Exhibit 4.68

     

 

    October 26,
    2006
    

 

    Multicell Technologies, Inc.

    701 George Washington Highway

    Lincoln

    RI 02865

    USA

 

    Dear Sirs

 

 

    Worldwide Exclusive License Agreement dated
    December 31st 2005 made between Multicell Technologies,
    Inc. (“Multicell”) and Amarin Neuroscience Limited
    (“Amarin”) (the “Agreement”)

 

    We refer to the Agreement, as amended by letter agreement dated
    June 27, 2006 (“First Amendment Letter”)
    and to recent discussions between Multicell and Amarin relating
    to the payment of the sum of $400,000 (the “Sum”)
    remaining payable by Multicell to Amarin pursuant to
    Section 3.2(a) of the Agreement, as amended by the First
    Amendment Letter.

 

    As per your proposal and our further discussions, it is agreed
    that the milestone and payment terms for the Sum (as set out in
    the Agreement, as amended by the First Amendment Letter) shall
    be further revised to payment by instalment
    (“Instalment(s)”) as follows:

 

				
	 	    • 
	
    $100,000 due on November 3, 2006;
	 
	 
	 	    • 
	
    $300,000 due on December 15, 2006
	 

 

    Notwithstanding the above, the Sum or any outstanding
    Instalment, shall in any event be due and payable in full by
    December 15, 2006.

 

    In the event that Multicell should raise finance in excess of
    $3,000,000 in a financing (other than bridging finance or equity
    line credit) prior to December 15, 2006, all outstanding
    amounts of the Sum shall be immediately payable.

 

    In the event that Multicell defaults in paying any of the Sum
    and/or the Instalments and notwithstanding Section 9.2(a)
    of the Agreement, Amarin shall, at its option, thereafter be at
    liberty to terminate the Agreement on the giving of seven
    (7) days prior written notice to Multicell at any time.

 

    For the avoidance of doubt Multicell shall have no cure period
    in respect of the non payment of the above Sum and/or the
    Instalments by the due date(s) set forth above.

 

													
	    Amarin
    Neuroscience Ltd
    	    •
    	    1 st
    Floor
    	    •
    	    Magdalen
    Centre North
    	    •
    	    The
    Oxford Science Park
    	    •
    	    Oxford
    	    •
    	    OX4 4GA
    	    •
    	    UK
    

							
	    Tel:
    +44 (0)1865 784210
    	    •
    	    Fax:
    +44 (0)1865 784213
    	    •
    	    Email:
    admin@amarin-neuro.com
    	    •
    	    Www.amarincorp.com
    

 

    Registered
    In Scotland No. 179838
    

    Registered
    Office: 4th Floor • Saltire
    Court • 20 Castle
    Terrace • Edinburgh • EHI 2EN • Scotland • UK
    

 

    
    

 

    - 2 -
    

 

 

    In the event that this letter agreement is not counter signed by
    Multicell and returned to Amarin on or before
    October 27,2006, then this letter agreement shall be null
    and void.

 

    Save as set out above, the parties’ respective rights and
    obligations under the Agreement shall remain unaffected.

 

 

    Yours faithfully

 

    

 

 

    Amendment terms agreed

 

    

 

													
	    Amarin
    Neuroscience Ltd
    	    •
    	    1 st
    Floor
    	    •
    	    Magdalen
    Centre North
    	    •
    	    The
    Oxford Science Park
    	    •
    	    Oxford
    	    •
    	    OX4 4GA
    	    •
    	    UK
    

							
	    Tel:
    +44 (0)1865 784210
    	    •
    	    Fax:
    +44 (0)1865 784213
    	    •
    	    Email:
    admin@amarin-neuro.com
    	    •
    	    Www.amarincorp.com
    

 

    Registered
    In Scotland No. 179838
    

    Registered
    Office: 4th Floor • Saltire
    Court • 20 Castle
    Terrace • Edinburgh • EHI 2EN • Scotland • UKexv4w69

 

 

    Exhibit
    4.69

 

    MASTER
    SERVICES AGREEMENT

 

			
	
    AGREEMENT		
    Made on the 15 day of November 2006 (“Effective
    Date”)
	 
	
    BETWEEN		
    ICON Clinical Research (UK) Limited doing business as ICON
    Development Solutions (hereinafter called “ICON”)
    of 2 Globeside, Globeside Business Park, Marlow, Bucks SL7 1HZ,
    UK
	 
	
    AND 		
    Amarin Pharmaceuticals Ireland Limited of 50 Pembroke
    Road, Ballsbridge, Dublin 4, Ireland (hereinafter called
    (“CLIENT”)

 

    WHEREAS CLIENT desires to retain ICON to provide, and ICON
    wishes to provide consultancy
    and/or other
    services (“the Services”), to CLIENT from time to time
    and subject to the terms and conditions of this Agreement and
    for the purposes set out herein and:

 

    WHEREAS the parties to this Agreement wish to agree upon the
    various terms and conditions that will govern their business
    relationship for the term specified in this Agreement in
    connection with the provision of Services by ICON to CLIENT.

 

    THE
    PARTIES HERETO AGREE AS
    FOLLOWS:

 

    1. (a) ENGAGEMENT —
    Subject to the terms and conditions set out in this
    Agreement, CLIENT hereby retains the services of ICON, and ICON
    hereby agrees to provide services (“the Services”)
    from time to time as may be specified in individual Project
    Contracts as set out below, in connection with the development
    of certain medical/biopharmaceutical products (the
    “Products”) as CLIENT requires.

 

    For the avoidance of doubt, this MSA is specific to the
    provision of due diligence services by ICON Development
    Solutions and is additional to that already in place with Amarin
    Corporation plc and, therefore, should in no way be construed as
    replacing or superseding that agreement.

 

    (b) SERVICES — The Services
    to be provided shall include but shall not be limited to:

 

    (i) Providing due diligence services and reports in respect
    of scientific, clinical
    and/or
    regulatory matters relating to companies
    and/or
    specified products in the manner requested by CLIENT;

 

    (ii) Such other services as may be required or as may
    otherwise be agreed between the parties, relating to the
    PRODUCTS.

 

    (c) TERMS &
    CONDITIONS

 

    (i) All Services provided by ICON under this agreement
    shall be subject to the ICON Plc Group Terms and Conditions as
    set out in Appendix A hereto, together with such specific
    terms or conditions as may be agreed in writing and specified in
    each Project Contract.

 

    Any terms and conditions in Project Contracts which conflict
    with any terms and conditions in this Agreement shall only be
    valid and enforceable where they are specifically identified in
    writing as such in the Project Contract and in that case shall
    only be valid and enforceable for that particular Project
    Contract. In the absence of any such provision the terms and
    conditions of this Agreement shall prevail.

 

    (d) PROJECT CONTRACTS

 

    (i) Each individual project assignment under this Master
    Services Agreement will be defined in numbered Project
    Contracts. Each Project Contract will be separately negotiated
    and executed by the parties and when so executed shall be
    incorporated into this Master Services Agreement by reference in
    Appendix B to this Master Services Agreement.

 

    (ii) Each Project Contract, together with the terms and
    conditions of this Agreement, shall constitute and be construed
    as a separate agreement.

 

 

    (e) AFFILIATES

 

    (i) ICON and CLIENT intend that their respective Affiliates
    may also execute Project Contracts. Unless the context requires
    otherwise, references to CLIENT or ICON in this Master Agreement
    (together with the related rights and obligations) as
    incorporated into a Project Contract shall apply to the CLIENT
    Affiliate or ICON Affiliate that is a party to the Project
    contract.

 

    (ii) For the purposes of this Agreement and any Project
    Contracts “Affiliate” shall mean any entity that
    controls, is controlled by, or is under the common control with
    that party. In this context “control” shall mean
    (1) ownership by one entity, directly or indirectly, of at
    least fifty percent (50%) of the voting stock of another entity,
    (2) power of one entity to direct the management or
    policies of another entity by contract or otherwise, or
    (3) any other relationship between a party and an entity
    which both CLIENT and ICON have agreed in writing may be
    considered an “Affiliate” of a party.

 

			
	 	    2.  
	
    TERM & TERMINATION

 

    (i) This Master Services Agreement shall take effect on the
    Effective Date and shall continue unless terminated as provided
    below.

 

    (ii) Each Project Contract shall take effect and terminate
    as designated in the Project Contract. Termination of this
    Master Services Agreement or any Project Contract shall not
    affect any other Project Contract: each Project Contract shall
    continue in force and effect unless specifically terminated in
    accordance with the terms of this Master Services Agreement or
    the terms of that Project Contract.

 

    (iii) Either party may terminate this Master Services
    Agreement
    and/or any
    Project Contract in the event of a material breach by the other
    party. The party seeking to terminate shall provide written
    notice to the party in breach setting forth in reasonable detail
    the nature of such breach. The breaching party shall have
    30 days within which to cure such breach. If the breaching
    party fails to cure within such
    30-day
    period, the party asserting the breach shall have the right to
    immediately terminate this Master Services Agreement
    and/or the
    relevant Project Contract.

 

    (iv) Either party may terminate this Master Services
    Agreement
    and/or a
    Project contract for any reason upon providing 90 days
    written notice to the other.

 

    (v) Either party may terminate this Master Services
    Agreement
    and/or a
    Project contract immediately upon written notice if:

 

    a. The other party becomes insolvent, or if proceedings are
    instituted against that other party for reorganization or other
    relief under any bankruptcy law, or if any substantial part of
    the other party’s assets come under the jurisdiction of a
    liquidator, receiver or trustee in an insolvency proceeding
    authorized by law, or;

 

    b. If there is a change in control of the other party by
    the acquisition by any person or entity, directly or indirectly,
    of more than fifty percent (50%) of the total voting capital
    stock of the other party or by any sale, lease, exchange or
    other disposition by that party of all or substantially all of
    its assets.

 

    (vi) In the event of early termination of this Master
    Services Agreement
    and/or a
    Project Contract for any reason, the parties agree that:

 

    a. They shall co-operate with one another to ensure the
    orderly winding down and transition of the services being
    provided and the transfer of all data, materials and information
    to the CLIENT thereof, and;

 

    b. CLIENT shall immediately pay to ICON all outstanding
    amounts in respect of fees earned and expenses or costs incurred
    up to the date of such early termination.

 

    3.  COMPENSATION — In
    consideration for its provision of services under a Project
    Contract, CLIENT shall pay ICON in accordance with the terms and
    amounts specified in the Project Contract.

 

    4.  GOVERNING LAW —
    This Agreement shall be governed by and construed in
    accordance with the law in force for the time being in England.

 

    IN WITNESS WHERE OF the parties hereto have
    cause this Agreement to be duly executed by their authorised
    representatives as of the dates written below.

 

	 	 	 
	
 
	
 
	
 

	
 
	
 
	
 

	

    AMARIN PHARMACEUTICALS

    IRELAND LIMITED

	
 
	
    ICON CLINICAL RESEARCH (UK)

    LTD doing business as ICON

    DEVELOPMENT SOLUTIONS

	
 
	
 
	
 

	

    Date: 11/12/06 
    

	
 
	
    Date: 15/11/06
    

	

    Title: Director 
    

	
 
	
    Title: Vice President
    

	
 
	
 
	
 

	

    SIGNED
    DARREN CUNNINGHAM
    

	
 
	
    SIGNED
    S. C. MUIR
    

 

    MASTER
    SERVICES AGREEMENT- APPENDIX A

 

    ICON
    CLINICAL RESEARCH (UK) LTD doing business as ICON

    DEVELOPMENT SOLUTIONS TERMS AND CONDITIONS FOR SUPPLY OF
    SERVICES

 

		
	
    1.  
	
    DEFINITIONS

 

    a. “ICON” shall mean ICON Plc
    and/or any
    of its subsidiary or associated companies.

 

    b. “CLIENT” shall mean the company, corporation,
    person or other legal entity to which Icon supplies services,
    which are subject to these Terms & Conditions.

 

    c. “FEES” shall mean collectively all sums due to
    ICON from CLIENT in consideration for the supply of services,
    together with all due Expenses and Costs.

 

    d. “EXPENSES” shall mean travel and accommodation
    expenses as agreed from time to time with CLIENT.

 

    e. “COSTS” shall mean all other charges arising
    in connection with the provision of services (other than service
    fees and Expenses) including, but not limited to fees payable to
    third parties, telecommunication costs, couriers, translation
    costs, photocopying and other such costs as are agreed with
    CLIENT.

 

    f. “PROPOSAL” shall mean the ICON proposal for
    the provision of Services as agreed with CLIENT.

 

    g. “SERVICES” shall mean consultancy or other
    such services to be provided by ICON as are agreed with CLIENT
    in a Project Contract or otherwise.

 

    h. “PROJECT CONTRACT” shall mean the legally
    binding agreement between ICON and CLIENT (whether in writing,
    orally or a combination of both), for the provision of Services
    by ICON to be subject to these Terms & Conditions.

 

    i “CONFIDENTIAL INFORMATION” shall mean the
    information defined in Clause 5 below.

 

		
	
    2.  
	
    SERVICES

 

    a. ICON shall provide services in good faith and with
    reasonable care and skill as agreed with CLIENT.

 

    b. Services shall be provided in accordance with all
    generally accepted professional standards and in compliance with
    all applicable laws, rules, regulations and Protocols.

 

    c. Any material change to the Services shall be agreed
    between ICON and CLIENT and shall be subject to any applicable
    amendments in fees, costs and expenses.

 

    d. A Proposal shall only become binding upon ICON if
    accepted in writing by CLIENT within 3 months of the date
    of the Proposal. If not so accepted, any assumptions or estimate
    costs in the Proposal may be subject to change by ICON.

 

    e. In the event that ICON, in good faith and at the written
    request of CLIENT, shall provide Services to CLIENT prior to or
    in contemplation of the formal execution of a Project Contract
    in respect of the provision of any Services, ICON shall be
    entitled to a payment by CLIENT in respect of any Services so
    provided, notwithstanding that such Project Contract shall not
    have been formally executed by ICON
    and/or
    CLIENT.

 

    f. In the event that CLIENT is responsible for providing
    ICON with data, materials or other information which is required
    by ICON to provide the Services and that delay materially
    adversely affects the provision of the Services, then CLIENT
    shall be responsible for ICON’S fees, costs and expenses in
    relation thereto
    and/or at
    CLIENT’S election, the time limit for the provision of the
    Services (as set out in an applicable time schedule of a Project
    Contract) shall be amended accordingly.

 

		
	
    3.  
	
    PAYMENT

 

    a. In consideration for the Services provided by ICON to
    CLIENT, CLIENT shall pay to ICON fees, expenses and costs as
    agreed in accordance with ICON’S Proposal
    and/or an
    applicable Project Contract or as may otherwise be agreed to by
    the parties in writing.

 

 

    b. Unless otherwise agreed, fees, expenses and costs shall
    be paid by monthly payments in arrears against an invoice from
    ICON describing the Services provided in the preceding month and
    consistent with a payment schedule agreed to by the parties in
    the applicable Project Contract.

 

    c. Invoices shall be paid by CLIENT within 30 days of
    receipt of invoice. Interest may be charged at the rate of
    1% per month or part thereof on any invoices overdue for
    payment longer than 30 days after receipt by CLIENT.

 

    d. If the provision of services is terminated before the
    contemplated completion date for any reason (except ICON’S
    fault, insolvency or bankruptcy) then ICON shall be entitled to
    payment of all fees and expenses outstanding in respect of
    Services provided up to the date of early termination, together
    with any reasonable costs necessarily incurred by ICON to
    complete its obligations in performing Services.

 

    e. If applicable, VAT
    and/or any
    other chargeable taxes shall be charged to each invoiced amount
    at the appropriate rate and shall be payable by CLIENT.

 

    f. Fees charged to CLIENT by ICON shall not, under any
    circumstances, exceed the total amount set forth in the Project
    Contract
    and/or
    Proposal unless the parties shall agree to such an increase in a
    written amendment to the Project Contract
    and/or
    Proposal in advance of any additional fees being incurred.

 

		
	
    4.  
	
    LIABILITY &
    INDEMNITY

 

    a. ICON shall not be liable for any loss, damage, claim,
    investigations or costs suffered or incurred by CLIENT or any
    third party resulting directly or indirectly from the provision
    of Services unless and to the extent that, such loss is due to
    ICON’S negligence, wilful misconduct or breach of its
    obligations in the provision of Services.

 

    b. CLIENT shall indemnify ICON, its servants or agents,
    against any claims by third parties alleging loss of or damage
    to any property or for the death or injury to any person arising
    directly or indirectly from the supply or use of any product or
    compound supplied by CLIENT and which is the subject of the
    provision of Services unless and to the extent that there is any
    negligence, wilful misconduct, breach of obligations on the part
    of ICON or its servants or agents in the provision of Services
    to CLIENT.

 

    c. ICON shall indemnify CLIENT, its servants or agents
    against any claims by third parties alleging loss of or damage
    to any property or for the death or injury to any person arising
    directly or indirectly due to ICON’S negligence, wilful
    misconduct or breath of its obligations in the provision of
    Services unless and to the extent that such a loss is due to
    CLIENT’S negligence or wilful misconduct.

 

		
	
    5.  
	
    CONFIDENTIALITY

 

    a. ICON acknowledges that during the course of providing
    Services to CLIENT, ICON
    and/or its
    servants or agents may be exposed to material and other
    information, which are confidential to CLIENT
    (“Confidential information” as defined herein). ICON,
    either by itself or through any of its servants or agents shall
    not use, disclose, publicize, disseminate, promote or advertise
    any Confidential Information for any purpose other than for the
    performance of Services for CLIENT, other than with the prior
    written consent of CLIENT, or as may be required by law, in
    which case ICON shall give CLIENT as much advance notice of the
    proposed disclosure as is practical (including a copy of any
    written request or order), and shall co-operate with CLIENT in
    any effort to limit or restrict such disclosure, via a
    protective order or otherwise.

 

    b. ICON acknowledges that all Confidential Information is
    the exclusive property of CLIENT and that ICON has no ownership
    or property right in such Confidential Information. Upon request
    by CLIENT, either during or after the provision of any Services,
    ICON shall return to CLIENT all Confidential Information in
    whatever form.

 

    c. “Confidential information” (which shall
    include “Inventions”), shall mean any information, in
    whatever form of a secret or private nature connected with the
    business of CLIENT or any of its suppliers or customers
    including, but not limited to, matters of a technical nature
    (such as; inventions, products, compositions, formulations,
    improvements, methods, know-how, designs, formulae, methods,
    developmental or experimental work, clinical data, improvements,
    discoveries, pending or potential patent claims, computer
    programs and research projects and any information derived there
    from), matters of a commercial nature (such as; unpublished
    financial information, pricing and costing information, profits,
    budgets, promotional methods, marketing sales, customers,

 

    suppliers and employees), business plans and any other
    information of a similar nature not ordinarily available
    publicly.

 

    d. “Confidential information” shall not include;

 

    (i) Information which is or becomes generally available to
    the public otherwise than by reason of a breach of these Terms
    and Conditions; or

 

    (ii) Information already in possession of ICON and is at
    its free disposal at the time of disclosure by CLIENT; or

 

    (iii) Information received by ICON from a third party under
    no obligation of confidentiality to CLIENT; or

 

    (iv) Information which was independently developed by ICON,
    as evidenced by written records; or

 

    (v) Information expressly identified in writing by CLIENT
    as not being confidential.

 

    e. Any inventions or discoveries (whether or not
    patentable), innovations, suggestions, ideas and reports
    (“Inventions”), made or developed by either ICON or
    CLIENT as a result of performing Services shall be promptly
    disclosed to CLIENT and shall be the sole property of CLIENT.

 

    f. Upon CLIENT’S request and at CLIENT’S cost,
    ICON will co-operate with CLIENT in obtaining patent or other
    proprietary protection concerning any Confidential Information.

 

		
	
    6.  
	
    FORCE
    MAJEURE

 

    a. If the performance of any obligation under these
    Terms & Conditions,
    and/or a
    Project Contract by either ICON or CLIENT is prevented,
    restricted or interfered with as a result of a Force Majeure,
    which shall mean causes beyond either ICON’S or
    CLIENT’S reasonable control, being acts of God, fires,
    strikes, acts of war, acts of terrorism, or intervention of a
    Governmental Authority,, that party shall, upon giving prompt
    notice to the other, be excused from performance to the extent
    of the prevention, restriction or interference but that party
    shall use its best efforts to avoid or remove such causes of
    non-performance and shall continue performance under the
    Terms & Conditions
    and/or
    Project Contract with the utmost speed whenever such causes are
    removed or diminished. In the event that a performance delay
    contemplated hereunder exceeds 30 days, the non-delaying
    party may immediately terminate the applicable Project Contract.

 

		
	
    7.  
	
    GENERAL

 

    a. Unless otherwise agreed in writing, these
    Terms & Conditions govern the supply of all Services by
    ICON to any CLIENT and ICON does not accept to any oral or
    written terms or conditions submitted by CLIENT unless ICON
    expressly agree in writing to accept a variation of these
    Terms & Conditions.

 

    b. ICON shall not assign any of its rights or obligations
    under any Contract without the prior written consent of CLIENT.

 

    c. No modification of these Terms & Conditions
    shall be deemed effective unless in writing and signed by both
    ICON and CLIENT and no waiver of any right herein shall be
    deemed effective unless in writing and signed by the party
    against whom the waiver is sought.

 

    d. If any of the provisions of these Terms &
    Conditions is held to be unenforceable or invalid by a court of
    competent jurisdiction, the validity and enforceability of the
    enforceable portion of any such provision
    and/or the
    remaining provisions shall not be affected thereby.

 

    e. These Terms & Conditions and any Contract which
    is subject to them shall be governed and construed in accordance
    with the laws of England.

 

 

    Client Darren Cunningham

 

    Date 23/11/06

 

    MASTER
    SERVICES AGREEMENT-APPENDIX B

    LIST OF PROJECT CONTRACTS UNDER MASTER SERVICES
    AGREEMENT

 

    1. PROJECT
    CONTRACT NO. 7076

 

    1.
    PROJECT CONTRACT NO. 7076

 

			
	
    PARTIES 		
    ICON CLINICAL RESEARCH (UK) LTD doing business as ICON
    Development Solutions (“ICON”) with offices
    located at 2 Globeside, Globeside Business Park, Marlow,
    Buckinghamshire, SL7 1HZ and Amarin Pharmaceuticals Ireland
    Limited of 50 Pembroke Road, Ballsbridge, Dublin 4, Ireland
    (hereinafter called “CLIENT”)
	 
	
    DATE 		
    EFFECTIVE DATE:  13 November 2006
	 
	
    TERMS 		

    1.  ICON agrees to supply to CLIENT the Services
    specified below at the Fees specified, subject to:

	 
	
		

         a.  The Master Services
    Agreement (“MSA”) dated [  ] November 2006
    (“MSA”) and specifically the Terms &
    Conditions of Appendix A of that Agreement.

	 
	
		

         b.  This Project
    Contract.

	 
	
		

    2.  This Project Contract and the Terms &
    Conditions of the MSA shall upon acceptance by CLIENT
    collectively comprise the Contract between ICON and CLIENT for
    the provision of the Services.

	 
	
		

    3.  ICON supplies the Services as an independent
    contractor and no relationship of employer or employee shall
    arise or be created under this Project Contract as and between
    CLIENT and ICON
    and/or any
    personnel engaged by ICON to provide the Services.

	 
	
		
    This Project Contract shall not become binding and ICON shall
    not be obliged to provide any Services until acceptance in
    writing of this Project Contract is received.
	 
	
    SERVICES 		
    Due diligence activities with respect to in-licensing
    opportunities for compounds with therapeutic potential in CNS
    disorders as instructed by Amarin
	 
	
    TIME SCHEDULE 		
    •  Project Start
    (Est):                 November
    2006
	 
	
		
    •  Project Completion
    (Est):          December
    2007
	 
	
    FEES 		
    Estimated costs for due diligence activities with respect to
    in-licensing opportunities for compounds with therapeutic
    potential in CNS disorders shall be as set forth in
    Appendix A to this Project Contract. The amount will not
    exceed £10,000 without prior consultation with Amarin.
	 
	
		
    Costs shall include all consulting fees and
    secretarial/administrative staff costs, but exclude other direct
    costs such as translations, purchase of publications,
    photocopying and binding, couriers, fees of regulatory agencies,
    travelling and accommodation expenses, and other disbursements
    to third parties as may be agreed with CLIENT from time to time.
	 
	
		
    Unless otherwise specified, this estimate does not include the
    cost of time spent by ICON staff in meetings, video or
    teleconferences with CLIENT, CLIENT’s experts or other
    third parties as required by CLIENT from time to time. Such
    meetings will be charged at the applicable hourly rate per
    person.
	 
	
		
    This estimate is based on data unseen and historical experience
    of projects of this nature; ICON reserves the right to review
    these costs 

 

			
	
		
    when fuller information is made available. Any changes in the
    scope of the project will be documented and agreed by both
    parties.
	 
	
		
    This estimate is valid for three months from the date indicated
    on the cover. ICON reserves the right to review these costings,
    if the proposal is not accepted within this period.
	 
	
		
    Consulting fees for the year to 31 May 2007 are listed in
    Appendix I to the Project Contract; ICON reserves the right
    to increase these fees on 1st June 2007.
	 
	
    PAYMENT SCHEDULE 		
    Invoices will be issued monthly itemising the hours worked
	 
	
    NOTICES 		
    Notices relating to this Project Contract shall be delivered and
    addressed as follows:

 

	 	 	 	 	 
	

    If to CLIENT:
    

	
 
	
    Contact Title
    
	
 
	
    Darren Cunningham
    

	
 
	
 
	
    Client Name
    
	
 
	
    Amarin Pharmaceuticals Ireland
    Limited
    

	
 
	
 
	
    Client Address
    
	
 
	
    50 Pembroke Road 

    Ballsbridge 

    Dublin 4 

    Ireland
    

	
 
	
 
	
    Phone:
    
	
 
	
    +353 (0)1 6699 020
    

	
 
	
 
	
    Fax:
    
	
 
	
    +353 (0)1 6699 028
    

	
 
	
 
	
    E-mail:
    
	
 
	
    Darren.Cunningham@amarincorp.com
    

	

    If to ICON:
    

	
 
	
    Contact
    
	
 
	
    Stuart Muir
    

	
 
	
 
	
    Title
    
	
 
	
    VP Global Regulatory Affairs
    

	
 
	
 
	
    Name 

    Address
    
	
 
	
    ICON Development Solutions 

    2 Globeside 

    Globeside Business Park

    MARLOW Buckinghamshire 

    SL7 1HZ
    

	
 
	
 
	
    Phone:
    
	
 
	
    01628 496300
    

	
 
	
 
	
    Fax:
    
	
 
	
    01628 496301
    

	
 
	
 
	
    E-mail:
    
	
 
	
    muirs@iconuk.com
    

	

    With copy to:
    

	
 
	
    Contact
    
	
 
	
    Steve Hayes
    

	
 
	
 
	
    Title
    
	
 
	
    Director, Business Development
    

	
 
	
 
	
    Name
    
	
 
	
    ICON Development Solutions
    

	
 
	
 
	
    Address
    
	
 
	
    2 Globeside 

    Globeside Business Park

    MARLOW Buckinghamshire 

    SL7 1HZ
    

	
 
	
 
	
    Phone:
    
	
 
	
    01628 496360
    

	
 
	
 
	
    Fax:
    
	
 
	
    01628 496301
    

	
 
	
 
	
    E-mail:
    
	
 
	
    hayesst@iconuk.com
    

 

			
	
    INVOICES and PAYMENTS 		
    All ICON invoices should be forwarded to CLIENT as follows:
	 
	
		
    Darren Cunningham
	 
	
		
    Amarin Pharmaceuticals Ireland Limited 50 Pembroke Road
	 
	
		
    Ballsbridge
	 
	
		
    Dublin 4
	 
	
		
    Ireland
	 
	
		
    All payments shall be in electronic form, payable to ICON
    Clinical Research (UK) Limited at:

 

	 	 	 	 	 
	

    Bank:
    

	
 
	
    Barclays Bank, Jewry Street,
    Winchester, SO23 8TN
    

	

    Account:
    

	
 
	
    ICON Clinical Research (UK)
    

	

    Account No.:
    

	
 
	
    60501425
    
	
 
	
 

	

    Sort Code:
    

	
 
	
    20 97 01
    
	
 
	
 

	

    Swift Code:
    

	
 
	
    BARCGB210NB
    
	
 
	
 

	

    IBAN No:
    

	
 
	
    IBAN GB21 BARC 2097 0160 5014 25
    

 

	 	 	 
	
    AMARIN PHARMACEUTICALS
    IRELAND

    
	
 
	
    ICON CLINICAL RESEARCH (UK)
    LTD

    

	
    LIMITED

    
	
 
	
    doing business as ICON DEVELOPMENT SOLUTIONS

	 

	

    Date: 13 November 2006
    

	
 
	
    Date: 15/11/06
    

	
 
	
 
	
 

	

    Name: Darren Cunningham
    

	
 
	
    Name: S. C. Muir
    

	
 
	
 
	
 

	

    Title: Director
    

	
 
	
    Title: Vice President
    

	
 
	
 
	
 

	

    SIGNED

	
 
	
    SIGNED 

 

    PROJECT
    CONTRACT NO. 7076 — APPENDIX A

    

 

    ICON
    DEVELOPMENT SOLUTIONS — CONSULTING FEES

 

    Hourly
    Rates to
    1st June
    2007

 

	 	 	 
	

    Project Assistant
    

	
 
	
    £51
    

	

    Publisher
    

	
 
	
    £78
    

	

    Documentum &
    E-Submissions
    Manager
    

	
 
	
    £147
    

	

    Regulatory Associate
    

	
 
	
    £74
    

	

    Regulatory Consultant
    

	
 
	
    £125
    

	

    Senior Consultant
    

	
 
	
    £147
    

	

    Principal Consultant
    

	
 
	
    £170
    

	

    Senior Director / Expert
    

	
 
	
    £191-216

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00118-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00118-of-00352.parquet"}]]