Document:

<PAGE>

                                                                    EXHIBIT 10.6

                               SUBLEASE AGREEMENT

                                     BETWEEN

                         PURDUE PHARMA, L.P, SUBLESSOR

                                       AND

                      AMICUS THERAPEUTICS, INC., SUBLESSEE

Building Address:      6 Cedar Brook Drive
                       Cranbury, New Jersey 08512

Subleased Premises:    A Portion of the First Floor and
                       The Entire Second Floor
<PAGE>

                               SUBLEASE AGREEMENT

      SUBLEASE AGREEMENT ("SUBLEASE") made as of this 12 day of May, 2005, by
and between PURDUE PHARMA L.P., a Delaware limited partnership having an office
at One Stamford Forum, Stamford, CT 06901-3413 ("SUBLESSOR") and AMICUS
THERAPEUTICS, Inc., a Delaware corporation having an office at 675 US Hightway
One, North Brunswick, NJ 08902 ("SUBLESSEE").

                                   WITNESSETH:

      WHEREAS, pursuant to a Lease Agreement dated as of December 13, 2000 (the
"PRIME LEASE"), between Cedar Brook 10 Corporate Center, L.P., as landlord
("LANDLORD"), and Sublessor, as tenant, Landlord leased to Sublessor certain
premises containing approximately 114,486 rentable square feet (the "PREMISES"),
in the building located at 6 Cedar Brook Drive, Cranbury, New Jersey 08512 (the
"BUILDING").

      WHEREAS, Sublessor desires to sublease to Sublessee and Sublessee desires
to sublease from Sublessor a portion of the Premises, consisting of a portion
of the first floor and the entire second floor of the Building, containing
approximately 31,906 rentable square feet which is made up of 12,293 rentable
square feet of laboratory space (the "LAB SPACE"), 11,308 rentable feet of
office space (the "OFFICE SPACE") and 8,305 rentable square feet of
unfinished(the "UNFINISHED SPACE") and shown outlined on the Floor Plan annexed
hereto as EXHIBIT A, and made a part hereof (collectively the "SUBLEASED
PREMISES"), on the terms, covenants and conditions hereinafter provided,

      NOW, THEREFORE, Sublessor and Sublessee covenant and agree as follows:

1.    SUBLEASE.

      (a) Sublessor hereby subleases to Sublessee, and Sublessee hereby hires
and subleases from Sublessor, the Subleased Premises.

      (b) The parties acknowledge and agree that for all purposes of this
Sublease, as of the Commencement Date (hereafter defined) (i) the Subleased
Premises conclusively shall be to contain 31,906 rentable square feet, (ii) the
Lab Space conclusively shall be deemed to contain 12,293 rentable square feet,
(iii) the Office Space conclusively shall be deemed to contain 11,308 rentable
square feet, and (iv) the Unfinished Space conclusively shall be deemed to
contain 8,305 rentable square feet.

2.    TERM.

      (a) The term (the "TERM") of this Sublease shall commence on the date
which is the later to occur of (i) the date when this Sublease has been fully
executed and delivered by both Sublessor and Sublessee, (ii) the date Sublessor
notifies Sublessee it has received the consent of the Landlord or Landlord's
consent was deemed given and (iii) the date that possession of the Subleased
Premises are provided to Sublessee (the "COMMENCEMENT DATE"), and shall expire
on February 28, 2012 or on such earlier date upon which the Term may expire or
terminate pursuant to any provision set forth herein (the "EXPIRATION DATE"). It
is expressly understood and agreed

<PAGE>

that Sublessee shall have no rights whatsoever to extend the Term and/or expand
the Subleased Premises, except as otherwise set forth in Section 29 of this
Sublease.

      (b) After the Commencement Date, Sublessee and Sublessor shall execute a
memorandum, in a form reasonably acceptable to both parties, memorializing the
Commencement Date. Notwithstanding the foregoing, Sublessee agrees that failure
or omission to execute such a memorandum will not effect the Commencement Date.

3.    BASE RENT.

During the entire Term, Sublessee shall pay Sublessor, as rent for each part of
the Subleased Premises, the following annual sums ("BASE RENT"), in equal
monthly installments, in advance on the first day of each month, without setoff
or deduction whatsoever (except to the extent otherwise specifically set forth
herein):

LAB SPACE AND
OFFICE SPACE:
<TABLE>
<CAPTION>
                                                                                 Annual Base Rent
                                                                                 Rate Per Rentable
          Period                     Annual Base Rent      Monthly Base Rent        Square Foot
--------------------------           ----------------      -----------------     -----------------
<S>                                  <C>                   <C>                   <C>
From the Commencement Date             $ 660,828.00            $ 55,069.00           $ 28.00
through and including
February 28, 2007

From March 1, 2007 through             $ 759,952.20            $ 63,329.35           $ 32.20
and including the
Expiration Date
</TABLE>

UNFINISHED
  SPACE:

<TABLE>
<CAPTION>
                                                                                 Annual Base Rent
                                                                                 Rate Per Rentable
          Period                     Annual Base Rent      Monthly Base Rent        Square Foot
--------------------------           ----------------      -----------------     -----------------
<S>                                  <C>                   <C>                   <C>
From the Commencement Date             $ 141,185.00            $ 11,765.42           $ 17.00
through and including
February 28, 2007

From March 1, 2007 through             $ 153,642.50            $ 12,803.54           $ 18.50
and including the
Expiration Date
</TABLE>

                                       2

<PAGE>

Notwithstanding the foregoing, Sublessor hereby grants Sublessee an abatement
of the Base Rent only (such abatement specifically excluding any additional
rent) for (i) the Lab Space and Office Space for the period commencing on the
Commencement Date and expiring on the date which is sixty (60) days next
following the Commencement Date and (ii) the Unfinished Space for the period
commencing on the Commencement Date and expiring on the date which is one
hundred and eighty (180) days next following the Commencement Date (the
"ABATEMENT PERIODS"), provided that no Event of Default has occurred and the
Sublease remains in full force and effect. In the event Sublessee shall default
with respect to any of its obligations under this Sublease at any time during
the Term of this Sublease, in addition to all of Sublessor's right and remedies
under This Sublease, Sublessor shall be entitled to full payment of Base Rent
for the Abatement Periods.

It the Commencement Date occurs on a day which is not the first day of a
calendar month, or if the Expiration Date occurs on a day which is not the last
day of a calendar month, then the Base Rent payable under this Sublease for such
month shall be appropriately adjusted so that Sublessee pays Base Rent only for
the portion of such calendar month occurring within the Term.

4.    ADDITIONAL RENT.

In addition to the Base Rent under Section 3 above, Sublessee shall pay
Sublessor additional rent as follows:

      (a) Operating Expense Payments. Commencing from and after the Commencement
Date, Sublessee shall pay to Sublessar, as additional rent, in equal monthly
installments, in advance on the first day of each month, (prorated for any
partial month) without setoff or deduction whatsoever the annual sum of
$332,944.45 ($27,745.38 per month; $10.50 per rentable square foot of the
Subleased Premises) (the "FIXED OPERATING EXPENSE CHARGE") as payment to
Sublessor for Sublessor's costs of operating and maintaining the Building.
Beginning on the first anniversary of the Commencement Date and on each
successive anniversary thereafter during the Term (the "ADJUSTMENT DATES") the
Fixed Operating Expense Charge shall be increased by three percent (3%) over the
Fixed Operating Expense Charge in effect for the period immediately preceding
the applicable Adjustment Date.

      (b) Real Estate Taxes and Landlord Common Charge.

            (i) Commencing from and after the Commencement Date, Sublessee shall
pay to Sublessor, as additional rent (prorated for any partial month)
without setoff or deduction whatsoever, an amount (the "TAX AND COMMON
CHARGE AMOUNT") equal to the Sublessee's proportionate share (i.e. 27.87%)
of the Sublessor's payments to Landlord under Article 8 of the Prime
Lease. Sublessee shall pay the Tax and Common Charge Amount to Sublessor within
thirty (30) days after the rendition of a bill thereof by Sublessor, from time
to time.

                                       3

<PAGE>

      (c) Electricity. Sublessee's costs for electrical current consumed in the
Subleased Premises is included in the Fixed Operating Expense Charge, but may be
increased pursuant to the terms of Section 6 herein.

      (d) Lab Gasses. Sublessee's costs for compressed air and natural gas
consumed in the Subleased Premises is included in the Fixed Operating Expense
Charge, but may be increased pursuant to the terms of Section 6 herein.

      (e) License Fee. Sublessee shall pay the Temp Lab Operating Expense Charge
as provided in Section 35 of this Sublease in the same manner as the Fixed
Operating Expense Charge.

      (f) Sums Due as Additional Rent. All sums of money (except for Base Rent)
as shall become due from Sublessee to Sublessor hereunder shall be deemed
additional rent. If Sublessee fails to make any payment of additional rent when
due, Sublessor shall have (in addition to all other remedies) the same rights
and remedies with respect thereto as provided in this Sublease(including,
without limitation, the provisions of the Prime Lease incorporated by reference)
for nonpayment of Base Rent or additional rent.

5.    RENT PAYMENTS.

      (a) All Base Rent, additional rent and other charges payable by Sublessee
to Sublessor under this Sublease shall be paid to Sublessor at the following
address:

                Purdue Pharma, L.P.
                One Stamford Forum
                Stamford, CT 06901
                Attention: James O'Brien, Chief Accountant

or such other place, or to such agent and at such place, as Sublessor may
designate by notice to Sublessee. Notwithstanding anything to the contrary set
forth herein, Sublessee shall pay the first installment of Monthly Base Rent,
the Fixed Operating Expense Charge, Tax and Common Charge Amount and Security
Deposit (as hereinafter defined) simultaneously with the execution and delivery
of this Sublease by Sublessee to Sublessor.

      (b) Notwithstanding the foregoing, Sublessee, at its election, may pay
any item of Base Rent, additional rent or other charges payable by Sublessee to
Sublessor under this Sublease by wire transfer made to such account as Sublessor
may have contemporaneously herewith designated in writing.

      (c) From time to time during the Term, Sublessor may designate a new
address and/or wire transfer account for payment of the aforesaid items by
giving reasonable prior written notice thereof to Sublessee in accordance with
the provisions of Section 19 hereof.

                                       4

<PAGE>

6.    UTILITY SERVICES.

      (a) Costs for consumption of electrical current, lab gasses, HVAC (as
hereinafter defined in Section 18) and other utilities in the Subleased Premises
are included in the Fixed Operating Expense Charge based on the use of the
Subleased Premises in strict conformity with the Permitted Use (as hereinafter
defined in Section 8). If the use of the Subleased Premises is not in strict
conformity with the Permitted Use, Sublessee shall, within thirty (30) days
after the rendition of a bill thereof by Sublessor, from time to time, pay
Sublessor for any additional costs incurred by Sublessor for such other use
including, without limitation, increased utility costs, Nothing herein shall be
deemed to allow Sublessee to use the Subleased Premises for any use other than
the Permitted Use.

      (b) Notwithstanding anything to the contrary in this Sublease, Sublessee
shall be entitled to HVAC service pursuant to the terms of Section 18 based upon
usage solely from the existing (as of the date of this Sublease) air handling
equipment serving the Subleased Premises. Sublessee shall pay for any additional
air handlers or additional HVAC service installed in or supplied to the
Subleased Premises, including without limitation, costs to submeter the
Subleased Premises, at Sublessee's sole cost and expense. Nothing herein shall
be deemed to allow Sublessee to install and/or use any additional air handling
equipment or HVAC service without Sublessor's consent which consent shall not be
unreasonably withheld provided such equipment or services (i) are consistent and
compatible with the existing Building HVAC systems, (ii) Landlord has approved
the installation of such services and (iii) Sublessee has complied with the
terms of Section 15 of this Sublease and all applicable terms of the Prime Lease
with respect to such equipment or services. If Sublessor, in its sole
discretion, shall supply any additional HVAC service, Sublessee shall pay the
costs thereof to Sublessor within thirty (30) days after the rendition of a bill
thereof by Sublessor, from time to time.

7.    OBLIGATION TO IMPROVE.

Sublessee shall improve the Unfinished Space, and cause it to be constructed, at
Sublessee's sole cost and expense, as a chemistry and biology lab in a manner
that is architecturally similar to the improvements currently existing in the
Building. Such improvements shall comply with all laws (as hereinafter defined)
and the terms of Section 15 hereof. Sublessee shall obtain Sublessor's consent
to the plans and specifications for such improvements pursuant to the terms of
Section 15 hereof. Sublessee shall commence the construction of the Unfinished
Space immediately after the Commencement Date and approval by Sublessor of the
plans and specifications for such construction and diligently pursue such
construction to completion. Sublessee shall complete the construction to the
Unfinished Space as required herein, on or prior to the nine (9) month
anniversary of the Commencement Date.

8.    USE

      (a) Sublessee (and any permitted occupants of the Subleased Premises)
shall use and occupy (i) the Lab Space as a customary biology and chemistry
laboratory, (ii) the Office Space for customary, general office use and (iii)
the Unfinished Space for a customary biology and chemistry laboratory,
(collectively, the "PERMITTED USE") provided however that each Permitted

                                       5
<PAGE>
Use is subject to all applicable zoning or other ordinances, rules, regulations,
orders, decrees, statues and laws of any governmental entity, board, or bureaus
(collectively "LAWS") and in no event shall Sublessee use or permit the use of
the Subleased Premises or any part thereof in any manner or for any purpose
which is not permitted under and consistent with the provisions of the Prime
Lease or as a vivarium. For purposes of this Sublease, the terms "customary
biology and chemistry laboratory" shall consist of customary research and
development for the operation of Sublessee's business but shall specifically
exclude (i) any chemical or biological production for commercial sale, (ii) BL3
or BL4 activities as classified by the US Center for Disease Control and (iii)
the housing of or experimentation with live animals of any kind.

      (b) Sublessee shall, at its sole cost and expense, shield all equipment
which generates or produces any electro-magnetic fields or emissions or wireless
communication devices so that all generated fields are reasonably contained
solely within the Subleased Premises and do not create any interference outside
the Subleased Premises. If Sublessee fails to shield all such equipment or
devices, Sublessee shall immediately remove and cease operation of such
equipment or devices within three (3) days after rendition of notice from
Sublessor to Sublessee advising Sublessee to remove such equipment or device.

9. CONDITION OF SUBLEASED PREMISES.

      (a) Sublessee acknowledges that Sublessee is hiring the Subleased Premises
in "as-is" condition as of the date hereof. In making and executing this
Sublease, Sublessee has not relied upon or been induced by any statements or
representations of any person with respect to the physical condition of the
Subleased Premises. Sublessee has relied solely on its own investigations,
examinations and inspections of the Subleased Premises.

      (b) Notwithstanding the provisions of Section 9(a) above, Sublessor hereby
agrees to deliver the Subleased Premises to Sublessee on the Commencement Date
in broom clean condition, including any and all fixtures, furniture and
furnishings (the "FURNITURE") existing within the Subleased Premises on the
Commencement Date which Sublessee shall accept in its "as is" condition on the
Commencement Date.

10. SUBORDINATION.

Sublessor and Sublessee agree that this Sublease is, and shall be, subject and
subordinate to all of the terms, covenants and conditions of the Prime Lease,
and to the matters to which the Prime Lease shall be subordinate. This Section
shall be self operative and no further instrument of subordination shall be
required to effectuate this provision.

11. INCORPORATION OF PRIME LEASE TERMS.

      (a) The terms, covenants and conditions of the Prime Lease are
incorporated herein by reference so that, except as set forth in Section 11 (b)
below or elsewhere in this Sublease, and except to the extent that such
incorporated provisions are inapplicable to or modified by Section 11(c)below or
other provisions of this Sublease (all such incorporated provisions, and all
such incorporated provisions as so modified, are herein called the "INCORPORATED
PROVISIONS"), all of

                                       6
<PAGE>
 the terms, covenants and conditions of the Prime Lease which bind or inure to
the benefit of the Landlord thereunder shall, in respect of this Sublease, bind
or inure to the benefit of Sublessor, said all of the terms, covenants and
conditions of the Prime Lease which bind or inure to the benefit of the Tenant
thereunder shall, in respect of this Sublease, bind or inure to the benefit of
Sublessee, with the same force and effect as if such incorporated terms,
covenants and conditions were completely set forth in this Sublease, and as if
the words "landlord" and "tenant" or words of similar import, wherever the same
appear in the Prime Lease, were construed to mean, respectively, "Sublessor" and
"Sublessee" in this Sublease, and as if the words "premises," "occupied
premises", "property" and "demised premises" or words of similar import,
wherever the same appear in the Prime Lease, were construed to mean "Subleased
Premises" in this Sublease, and as if the word "lease" or words of similar
import, wherever the same appear in the Prime Lease, were construed to mean this
"Sublease" except that references to "Occupied Premises" in Article 7 of the
Prime Lease shall be deemed to refer to the "Subleased Premises" only and
references to "Landlord" therein shall be deemed to refer to Landlord and not
Sublessor. Sublessee shall not do, or permit to be done, any act or thing that
would result in an increase in any of the rents, additional rents, or any other
sums or charges payable by Sublessor under the Lease or any other obligation or
liability of Sublessor under the Lease or that is (or, with notice and/or the
passage of time, would be) a default under the Lease.

      (b) The following provisions of the Prime Lease shall not be incorporated
herein by reference and shall not apply to this Sublease: the preamble and
witness statements; Article 1; Article 2; Article 3 except Sections 3.12 (a) and
(b) and except that Sublessee shall comply with Section 3.12 and all references
to "Landlord" in these Sections shall be deemed to refer to Landlord and not
Sublessor; Articles 4 - 6; the third sentence in Section 7.1, the first and
second sentences in Section 7.2; Article 8; Article 9 except that any signage
proposed by Sublessee shall be in compliance with Section 33 of this Sublease;
Articles 10-11; Sections 12.1(a)(ii)and b(ii), the penultimate sentence in
Section 12.3, the eleventh sentence in Section 12.4 and all of 12.5; Article 16;
Article 18; Article 20; Article 21; Article 24; Sections 25.4(a) and (b);
Article 27; Article 28; Article 31; Article 34; Article 35; Articles 37 & 38;
Article 40; Articles 43 - 46; Sections 47.1 - 47.13, 47.15 - 47.17, 47.20,
Article 48, Article 49 and all exhibits to the Prime Lease.

      (c) The following provisions of the Prime Lease shall be incorporated
herein by reference, but shall be modified as indicated:

            (i) The definition of "Commencement Date" set forth in the Prime
Lease shall be deleted in its entirety and replaced with the definition of
"Commencement Date" set forth above in this Sublease.

            (ii) The definition of "Expiration Date" set forth in the Prime
Lease shall be deleted in its entirety and replaced with the definition of
"Expiration Date" set forth above in this Sublease.

            (iii) The definition of "Fixed Rent" under the Prime Lease shall be
replaced with the definition of "Base Rent" set forth above in this Sublease.

                                       7
<PAGE>

            (iv) The definition of "Term" under the Prime Lease shall be
modified to mean the term of this Sublease as described above in this Sublease.

      (d) To the extent any term or condition of this Sublease conflicts with
any term or condition of the Prime Lease, as between Sublessor and Sublessee
(but not as to Landlord), this sublease shall govern.

      (e) Any and all representations and warranties of Landlord set forth in
the Prime Lease shall be deemed to be representations and/or warranties of
Landlord and shall not be deemed to be representations and/or warranties of
Sublessor and Sublessee shall look solely to Landlord in connection with any
breach and/or enforcement thereof.

      (f) All provisions of the Prime Lease that require Sublessor, as tenant,
to submit, exhibit, supply or provide to Landlord, as lessor, evidence,
certificates, or any other matter or thing shall be deemed to require Sublessee
to submit, exhibit, supply or provide the same to both Landlord and Sublessor.
Sublessee shall submit, exhibit, supply or provide the same to Sublessor and
Sublessor shall submit the same to Landlord, provided however that the submittal
to Landlord of any such materials by Sublessor shall not be deemed consent to
any request for approval by Sublessee. In no event shall Sublessee make any
direct submissions or requests or provide any documentation or materials
directly to Landlord.

      (g) Whenever the approval or consent of Landlord is required under any
provision of the Prime Lease or this Sublease, Sublessee shall be required to
obtain the written approval or consent of Sublessor, and Sublessor shall forward
any request for consent and thereafter use commercially reasonable efforts to
obtain like approval or consent of Landlord. Whenever Sublessor has agreed that
a required approval or consent shall not be unreasonably withheld or delayed it
shall be deemed reasonable for Sublessor to withhold or delay its approval or
consent if Landlord shall have delayed or refused to give any approval or
consent that may be requested of if related to the same matter. Sublessor shall
have no liability for any failure or refusal on the part of Landlord to grant
any such approval or consent. Nothing contained herein shall require Sublessor
to grant its approval or consent merely because Landlord has granted it approval
or consent.

12. SUBLESSEE'S DEFAULT/INDEMNIFICATION AND SUBLESSOR'S REMEDIES.

      (a) An "Event of Default," or default by Sublessee as used in this
Sublease, shall mean (i) any default by Sublessee under any term, covenant or
condition of this Sublease (including, without limitation, any provision of the
Prime Lease incorporated herein by reference) and which default shall have been
continued beyond applicable cure periods provided in this Sublease, (ii) any
default of tenant under the Prime Lease, if the same is caused by an act of
default of Sublessee, (iii) default in the payment of Base Rent or additional
rent within three (3) days after Sublessor's notice to Sublessee that same is
due; (iv) Sublessee's failure to perform any other non-monetary provision of
this Sublease within thirty (30) days (or immediately if the failure involves a
hazardous condition or may cause a default or forfeiture under the Prime Lease
or may cause a violation of Law) after notice from Sublessor; (v) Sublessee's
failure to restore or increase the Security Deposit as required in Section 25
herein;

                                       8
<PAGE>
 (vi) Sublessee's abandonment or vacatur of the Subleased Premises (which shall
be conclusively presumed if the Subleased Premises remains unoccupied for more
than 10 consecutive days); (vii) any voluntary or involuntary proceedings are
filed by or against Sublessee under any bankruptcy, insolvency or similar laws
and, in the case of any involuntary proceedings, are not dismissed within thirty
(30) days after filing or (viii) Sublessee's failure or inability to, or
admitting in writing of its inability to, pay its debts as they become due.

      (b) If Sublessee shall be in default of any term, covenant or condition of
this Sublease, Sublessor shall have available to it all of the remedies
available to Landlord under the Prime Lease in the event of a like default on
the part of the tenant thereunder. The mention in the Prime Lease or this
Sublease of any particular right or remedy shall not preclude Sublessor from
exercising any and all other rights and remedies available to it hereunder at
law and in equity or pursuant to the terms of this Sublease. Upon an occurrence
of any default or Event of Default by Sublessee, Sublessor shall also have the
following rights and remedies, any one of which may be pursued successively or
cumulatively as Sublessor may elect: (i) accelerate all Base Rent, additional
rent and other sums due or to become due hereunder, which shall thereupon be
immediately due and payable in full and (ii) Sublessor may terminate the right
of Sublessee to possession of the Subleased Premises without terminating this
Sublease by giving notice thereof to Sublessee and Sublessor may remove all
occupants and property from the Subleased Premises, using such force as may be
necessary to the extent allowed by laws, without being guilty of in any manner
of trespass, eviction or forcible entry and without relinquishing Sublessor's
right to Base Rent or any additional rent or any other right given to Sublessor
hereunder or by operation of law or in equity. Notwithstanding anything to the
contrary herein or in the Prime Lease, Sublessor shall not have any obligation
to relet the Subleased Premises or otherwise mitigate its damages in the event
of a default by Sublessee.

      (c) Sublessee shall indemnify, defend and hold harmless Sublessor from and
against all claims, liabilities, damages, losses, costs and expenses (including
reasonable attorneys' fees and disbursements) attributable to any damages that
Landlord shall seek to recover from Sublessor attributable to a default by
Sublessee under the terms of this Sublease and Sublessee shall also indemnify,
defend and hold Sublessor harmless from and against all claims, damages,
liabilities, losses, costs, expenses (including, without limitation, reasonable
attorney's fees and disbursements) which Sublessor incurs due to a failure by
Sublessee to comply with any obligation of Sublessee under this Sublease or
which arises from the use or occupancy of the Subleased Premises or any business
conducted therein or any accident or occurrence therein or from any work or
thing whatsoever done by or any condition created by or any other act or
omission of Sublessee.

      (d) In addition, Sublessee shall not do, or permit to be done by any party
for whom Sublessee is legally responsible, any act or thing in or with respect
to the Subleased Premises which will constitute a default under, or violation
of, any of the terms, covenants or conditions of the Prime Lease which pertain
to the Subleased Premises. Sublessee shall indemnify, defend and hold Sublessor
harmless from and against all claims, losses, costs, expenses (including
attorneys' fees and disbursements), damages and liability which Sublessor incurs
due to a failure by Sublessee to comply (after the expiration of all applicable
notice and cure periods)

                                       9
<PAGE>

with any obligation of Sublessee under this Sublease which would constitute a
default or under, or violation of, the Prime Lease.

      (e) Sublessor shall not take any action or fail to take any action which
would be an Event of Default under the Prime Lease, provided the same does not
arise out of or is a result of any action or failure to act by Sublessee.
Sublessor shall indemnify, defend and hold Sublessee harmless from and against
all claims, losses, costs, expenses (including reasonable attorneys' fees and
disbursements), damages and liability which Sublessee incurs due to (i) any
breach or nonperformance of any term contained in this Sublease or the Prime
Lease on the part of Sublessor to be observed, provided the same is not due to
negligence of Sublessee or a breach or failure by Sublessee (or anyone acting by
or through Sublessee) to perform under the terms of this Sublease and (ii) any
injury to persons in or about the Subleased Premises and caused by or resulting
from the fault of Sublessor, its agents, employees, contractors or visitors. The
provisions of Sections 12 (c), (d) and (e) hereunder shall survive the
expiration or earlier termination of this Sublease.

13. LIABILITY INSURANCE.

      (a) Sublessee agrees that during the Term it shall obtain and keep in
force the insurance policies required of Sublessor as tenant under Sections
8.4(b) -8.5 of the Prime Lease and such other insurance as Sublessor may from
time to time reasonably require that Sublessee maintain and all such policies
shall include the Sublessee, as insured, and Sublessor and Landlord, as
additional insureds.

      (b) Sublessee shall furnish a certificate of insurance evidencing all of
the above-described insurance policies prior to or upon execution of this
Sublease and annually, no later than ten (10) business days after the expiration
of each policy. All policies shall provide that no less than thirty (30) days
prior written notice of cancellation, or non-renewal shall be given to the other
party.

14. RESTRICTION ON ASSIGNMENTS, ETC.

      (a) Sublessee shall not assign, mortgage, pledge, encumber, or otherwise
transfer this Sublease, whether by operation of law or otherwise, and shall not
sub-sublet (or underlet), or permit or suffer the Subleased Premises or any part
thereof to be used or occupied by others (whether for desk space, mailing
privileges or otherwise), without Sublessor's prior consent in each instance
which may be withheld in Sublessor's sole discretion. Any assignment,
sub-sublease, mortgage, pledge, encumbrance or transfer in contravention of the
provisions of this Section 14 shall (i) constitute an Event of Default under
this Sublease and (ii) be null and void.

      (b) If Sublessee is a corporation, the transfer by one or more transfers,
directly or indirectly, by operation of law or otherwise, of a majority of the
stock of Sublessee shall be deemed a voluntary assignment of this Sublease;
provided, however, that the provisions of this Section 14(f) shall not apply to
the transfer of shares of stock of Sublessee if and so long as Sublessee is
publicly traded on a nationally recognized stock exchange. For purposes of this
Section the term "transfers" shall be deemed to include the issuance of new
stock or of treasury

                                       10
<PAGE>

stock which results in a majority of the stock of Sublessee being held by a
Person or Persons, that do not hold a majority of the stock of Sublessee on the
date hereof. If Sublessee is a partnership, the transfer by one or more
transfers, directly or indirectly, by operation of law or otherwise, of a
majority interest in the partnership shall be deemed a voluntary assignment of
this Sublease. If Sublessee is a limited liability company, trust, or any other
legal entity (including a corporation or partnership), the transfer by one or
more transfers, directly or indirectly, of Control of such entity, however
characterized, shall be deemed a voluntary assignment of this Lease.

      (c) Notwithstanding anything to the contrary herein and provided the same
is permitted pursuant to the terms of the Prime Lease, Sublessee shall have the
right, without Sublessor's consent but upon thirty (30) days prior notice, to
assign this Sublease to a successor entity by merger or acquisition provided
that (i) the nature of the business and the proposed use of the Subleased
Premises shall be the same as the Permitted Use, and (ii) the net worth of the
successor entity shall be equal to or greater than Sublessee's net worth on the
date of this Sublease. No assignment shall be binding on Sublessor unless such
assignee shall deliver to Sublessor an instrument containing a covenant of
assumption by such assignee. Notwithstanding the foregoing, such assignment must
not have been entered into, in whole or in part, as a subterfuge to avoid the
obligations and restrictions set forth in this Sublease and no assignment shall
act to release Sublessee from its obligations under this Sublease.

15. ALTERATIONS.

The following provisions regarding alterations shall supplement and be in
addition to the provisions of the Prime Lease regarding alterations:

      (a) (i) SUBLESSEE'S ALTERATIONS. Sublessee shall not make any alterations,
additions or other physical changes in or about the Subleased Premises, or other
alterations to prepare the Subleased Premises for its use (collectively,
"ALTERATIONS"), other than decorative Alterations such as painting, wall
coverings and floor coverings (collectively, "DECORATIVE ALTERATIONS"), without
Sublessor's (and if required by the Prime Lease, Landlord's) prior consent,
which may be withheld in Sublessor's and/or Landlord's sole discretion.
Sublessor will not unreasonably withhold its consent to Alterations so long as
such Alterations (i) are non-structural and do not affect the building
systems, (ii) are performed by contractors approved by Sublessor and/or Landlord
to perform such Alterations, (iii) affect only the Subleased Premises and are
not visible from outside of the Subleased Premises or the Building, (iv) do not
affect the certificate of occupancy issued for the Building or the Subleased
Premises, (v) are consistent with the design, construction and equipment of the
Building, (vi) do not adversely affect any service furnished by Landlord or
Sublessor in connection with the operation of the Building, (vii) are in
compliance with all the terms of the Prime Lease and (viii) are consented to by
Landlord pursuant to the terms of the Prime Lease. Notwithstanding anything to
the contrary herein, all alterations by Sublessee shall be architecturally
similar to the existing improvements in the building in Sublessor's reasonable
judgment and all construction materials and laboratory furnishings shall be of
equal or greater quality than those currently existing in the Building and any
fume hoods and biosafety cabinets installed by Sublessee shall be from the same
manufacturer.

                                       11
<PAGE>

            (ii) PLANS AND SPECIFICATIONS. Prior to making any Alterations,
Sublessee, at its expense, shall (i) submit to Sublessor (and if required by the
Prime Lease, to Landlord) for its approval, detailed plans and specifications
(including layout, architectural, mechanical, electrical, plumbing, sprinkler
and structural construction drawings using the AutoCAD Computer Assisted
Drafting and Design System, Version 12 or later of each proposed Alteration
(other than Decorative Alterations), (ii) obtain all permits, approvals and
certificates required by any governmental authorities, (iii) furnish to
Sublessor and to Landlord duplicate original policies or certificates of
insurance (covering all persons to be employed and work to be completed by
Sublessee, and Sublessee's contractors and subcontractors in connection with
such Alteration) evidencing insurance policies and the terms as required in
Section 13, and (iv) furnish to Sublessor and Landlord such other evidence of
Sublessee's ability to complete and to fully pay for such Alterations (other
than Decorative Alterations), including posting a bond or other security, as is
satisfactory to Sublessor (and if required by the Prime Lease, Landlord).
Sublessee shall give Sublessor and Landlord (as required) not less than five (5)
Business Days' notice prior to performing any Decorative Alteration, which
notice shall contain a description of such Decorative Alteration.

            (iii) GOVERNMENTAL APPROVALS; PLANS. Upon completion of any
Alterations, Sublessee, at its expense, shall promptly obtain certificates of
final approval of such Alterations required by any Governmental Authority, and
shall furnish Sublessor and Landlord with copies thereof, together with
"as-built" plans and specifications for such Alterations (other than Decorative
Alterations) prepared on the AutoCAD Computer Assisted Drafting and Design
Systems Version 12 or later (or such other system or medium as Sublessor and
Landlord may accept), using naming conventions issued by the American Institute
of Architects in June, 1990 (or such other naming convention as Sublessor and
Landlord may accept) and magnetic computer media of such record drawings and
specifications, translated into DXF format or another format acceptable to
Sublessor and Landlord.

      (b) MANNER AND QUALITY OF ALTERATIONS. All Alterations shall be performed
(i) in a good and workmanlike manner and free from defects, (ii) in accordance
with the plans and specifications as required under paragraph (a) above, and by
contractors, approved by Sublessor and Landlord, (iii) under the supervision of
a licensed architect reasonably satisfactory to Sublessor and Landlord (other
than Decorative Alterations), and (iv) in compliance with all in compliance with
all applicable Laws, the terms of this Sublease, all procedures and regulations
then prescribed by Landlord for work performed in the Building. All materials
and equipment to be used in the Subleased Premises shall be of equal or greater
quality than those currently existing in the Building as of the date of this
Sublease, and no such materials or equipment shall be subject to any lien or
other encumbrance.

      (c) REMOVAL OF SUBLESSEE'S PROPERTY. All Building Standard Alterations (as
defined in this Section) shall be the property of Sublessor and/or Landlord and
shall not be removed by Sublessee without the prior approval of Sublessor. All
Above Building Standard Alterations (as defined in this Section) and Sublessee's
property shall be and, except as hereinafter provided, shall remain the property
of Sublessee. On or prior to the Expiration Date or sooner termination of the
Term, Sublessee shall, at Sublessee's expense, remove all of Sublessee's
property and, unless otherwise directed by Sublessor and/or Landlord: (i) close
up any slab penetrations in the

                                       12
<PAGE>

Premises and (ii) remove any Alterations which (x) Sublessor is required to
remove pursuant to the Prime Lease, (y) Sublessor advised Sublessee it must
remove at the time of approval of Sublessee's plans for such Alterations and/or
(z) are Above Building Standard Alterations (but nothing herein shall give
Sublessee a right to make any such alterations, additions and improvements). At
least sixty (60) days prior to commencing the removal of any Alterations
(including without limitations those specified in the preceding sentence) or the
closing of any slab penetrations, Sublessee shall notify Sublessor of its
intention to remove such Alterations or effect such closings, and if Sublessor
and/or Landlord notifies Sublessee within such sixty (60) day period, Sublessee
shall not remove such Alterations or close such slab penetrations, and the
Alterations not so removed shall become the property of Sublessor and/or
Landlord upon the Expiration Date or sooner termination of the Term. Sublessee
shall repair and restore, in a good and workmanlike manner, any damage to the
Subleased Premises and/or the Building caused by Sublessee's removal of any
Alterations or Sublessee's property, or by the closing of any slab penetrations,
and if Sublessee fails to do so, Sublessee shall reimburse Sublessor and/or
Landlord, on demand, for Sublessor's and/or Landlord's cost of repairing and
restoring such damage. Any Above Building Standard Alterations or Sublessee's
property not removed on or before the Expiration Date or sooner termination of
the Term shall be deemed abandoned (unless Sublessor previously advised
Sublessee that it shall not so remove such Above Building Standard Alterations)
and Sublessor may either retain the same as Sublessor's property or remove and
dispose of same, and repair and restore any damage caused thereby, at
Sublessee's cost and without accountability to Sublessee. For the purposes of
this Sublease, (x) Alterations and improvements, the cost of which generally
conform to the cost of improvements typically performed in connection with the
initial occupancy of tenants in the Building for office and laboratory use are
defined as "BUILDING STANDARD ALTERATIONS", and (y) Alterations or improvements
which exceed Building Standard Alterations are defined as "ABOVE BUILDING
STANDARD ALTERATIONS". Notwithstanding anything to the contrary herein,
Sublessee shall not remove any laboratory benches or fume hoods from the
Subleased Premises whether currently existing on the Subleased Premises or
installed after the Commencement Date and all improvements made to the
Unfinished Space by Sublessee which are standard laboratory improvements shall
be deemed Building Standard Alterations and shall not be removed by Sublessee
unless Sublessor so advised Sublessee prior to the expiration of the Term that
Sublessee shall remove the same.

      (d) MECHANIC'S LIENS. Sublessee, at its expense, shall discharge any lien
or charge filed against the Subleased Premises, the Building or the Real
Property in connection with any work claimed or determined in good faith by
Sublessor and/or Landlord to have been done by or on behalf of, or materials
claimed or determined in good faith by Sublessor and/or Landlord to save been
furnished to, Sublessee, within twenty (20) days after Sublessee's receipt of
notice thereof by payment, filing the bond required by law or otherwise in
accordance with law.

      (e) LABOR RELATIONS. Sublessee shall not employ, or permit the employment
of, any contractor or laborer, or permit any materials to be delivered to or
used in the Building, if, in Sublessor's and/or Landlord's sole judgment, such
employment, delivery or use will interfere or cause any conflict or disharmony
with other contractors or laborers engaged in the construction, maintenance or
operation of the Building by Landlord, Sublessee or others, or the use and
enjoyment of the Building by other tenants or occupants. In the event of such
interference,

                                       13
<PAGE>

conflict or disharmony, upon Sublessor's and/or Landlord's request, Sublessee
shall cause all contractors or laborers causing such interference or conflict to
leave the Building immediately.

      (f) SUBLESSEE'S COSTS. To the extent that any fees (administrative or
otherwise) are due Landlord in connection with any Alterations made by Sublessee
in the Subleased Premises (including the Initial Installations), Sublessee shall
pay to Sublessor, within ten (10) days after demand, all out-of-pocket costs
incurred by Sublessor in connection therewith, including, but not limited to,
costs incurred in connection with (i) review of the Alterations (including
review of requests for approval thereof), and (ii) the provision of Building
personnel during the performance of any Alterations required by trade union
policy or otherwise, to operate elevators or otherwise to facilitate Sublessee's
Alterations.

      (g) SUBLESSEE'S EQUIPMENT. Sublessee shall not move any heavy machinery,
heavy equipment, freight, bulky matter or fixtures into or out of the Building
without Sublessor's and/or Landlord's prior consent and payment to Sublessor or
Landlord of Landlord's reasonable charges in connection therewith. If any such
machinery, equipment or other items require special handling, Sublessee agrees
(i) to employ only persons holding a Master Rigger's License to perform such
work, and (ii)such work shall be done only during hours designated by Landlord.

      (h) LEGAL COMPLIANCE. The approval of plans or specifications, or the
consent by Sublessor and/or Landlord to the making of any Alterations, does not
constitute Sublessor's and/or Landlord's agreement or representation that such
plans, specifications or Alterations comply with any Laws or the certificate of
occupancy issued for the Building. Neither Sublessor nor Landlord shall have any
liability to Sublessee or any other party in connection with Sublessor's and/or
Landlord's approval of plans and specifications for any Alterations, or
Sublessor's and/or Landlord's consent to Sublessee's performing any Alterations.
If, as the result of any Alterations made by or on behalf of Sublessee,
Sublessor and/or Landlord is required to make any alterations or improvements to
any part of the Building in order to comply with any Laws, whether or not in the
Subleased Premises, Sublessee shall pay all costs and expenses incurred by
Sublessor and/or Landlord in connection with such alterations or improvements.

      (i) LANDLORD'S RIGHT OF CONSTRUCTION. Notwithstanding anything to the
contrary herein, Sublessee shall comply with the provisions of Section 3.12 of
the Prime Lease with respect to any alterations or improvements to the
Unfinished Space and shall afford Landlord its construction right of first
refusal as provided therein.

      (j) SUBLESSEE CONSTRUCTION OF THE UNFINISHED SPACE. Sublessor acknowledges
that Sublessee is to build-out the Unfinished Space pursuant to the terms of
Section 7 of this Sublease (the "UNFINISHED SPACE ALTERATIONS") and that the
Unfinished Space Alterations may affect the building systems and structure of
the Building. Notwithstanding anything to the contrary herein, Sublessor will
not unreasonably withhold its consent to the Unfinished Space Alterations
provided (i) Landlord consents to the Unfinished Space Alterations, (ii) such
alterations do not adversely affect building systems or the structural integrity
of the building and (iii) such alterations otherwise comply with the provisions
of this Section 15.

                                       14
<PAGE>
     (k) ENTRANCE APPEARANCE. Notwithstanding anything to the contrary in this
Sublease, Sublessee shall not make any Alterations that may change the
appearance of the space visible from the main lobby area without Sublessor's
consent which may be withheld in Sublessor's sole discretion, it being
understood that this space shall remain a first-class office/reception area at
all times during the Term.

16.  REPAIRS

     (a) Sublessee shall make all repairs or replacements that Sublessor is
required to make under the Prime Lease with respect to the Subleased Premises.
To the extent Landlord makes any repair or replacement with respect to the
Subleased Premises for which Sublessor is required to pay for all or any of the
cost thereof, Sublessee shall, within thirty (30) days after rendition of a bill
thereof by Sublessor from time to time, pay Sublessor for any such cost for
which Sublessor is liable.

     (b) Sublessor reserves the right to make any and all changes, alterations,
additions, improvements, repairs or replacements to any and all pipes, wires,
cables, ducts, conduits and other equipment used by Sublessor to provide to
Sublessee any of the services provided by Sublessor to Sublessee pursuant to
this Sublease, as Sublessor deems necessary or desirable, provided that in no
event shall the level of any such service decrease in any material respect from
the level required of Sublessor in this Sublease as a result thereof (other than
temporary changes in the level of such services during the performance of any
such work by Sublessor). Sublessor shall use reasonable efforts to minimize
interference with Sublessee's use and occupancy of the Subleased Premises during
the making of such changes, alterations, additions, improvements, repairs or
replacements, provided that Sublessor shall have no obligation to employ
contractors or labor at overtime or other premium pay rates or to incur any
other overtime costs or additional expenses whatsoever. Except as otherwise
provided herein, there shall be no abatement of Base Rent or any additional rent
or allowance to Sublessee for a diminution of rental value, no actual or
constructive eviction of Sublessee, in whole or in part, no relief from any of
Sublessee's other obligations under this Sublease, and no liability on the part
of Sublessor, by reason of inconvenience, annoyance or injury to business
arising from Landlord, Sublessor, Sublessee or others making, or failing to
make, any repairs, alterations, additions or improvements in or to any portion
of the Building or the Subleased Premises, or in or to fixtures, appurtenances
or equipment therein.

17.  FURNITURE.

     (a) Sublessee shall have the right, without charge by Sublessor therefor,
to use all of the Furniture and telephone desk sets in the Subleased Premises,
provided that Sublessee shall, throughout the term of the Sublease, take good
care of same at Sublessee's sole cost and expense. All damage to the Furniture
and telephone desk sets shall be repaired promptly by Sublessee at its sole cost
and expense. Sublessee shall, at the expiration or earlier termination of the
Sublease term, surrender all Furniture and telephone desk sets to Sublessor in
the condition it was in on the Commencement Date subject, however, to reasonable
wear and tear. Sublessee shall use the Furniture in a reasonable manner and only
for the uses for which it was intended.

                                       15
<PAGE>

Sublessee accepts all risks with respect to the Furniture and Sublessor shall
not be liable for any damage or loss caused by or attributable to the Furniture.

     (b) Notwithstanding anything to the contrary in this Sublease, Sublessee
shall obtain and use its own telephone switch (PBX equipment) and
telecommunications services, at its sole cost and expense.

     (c) Sublessor shall disconnect the existing data/voice wiring from the main
point of demarcation in the Subleased Premises on or prior to the Commencement
Date. Sublessee shall reterminate and redirect such wiring within the Subleased
Premises at Sublessee's sole cost and expense.

18.  SERVICES/NON-LIABILITY OF SUBLESSOR/RENT ABATEMENT.

     (a) Sublessor shall have no obligation to comply with any laws, perform any
work, or provide any services or make any repairs in or to the Subleased
Premises whatsoever or to maintain any insurance or to perform any other
obligation which is the obligation of Landlord under the Prime Lease. Sublessee
recognizes that all services and repair obligations other than those to be
provided by Sublessor pursuant to Sections 18(b) and (c) and Section 32, to
which Sublessee is entitled under this Sublease are to be supplied by Landlord
under the Prime Lease and not by Sublessor. In the event that Landlord shall
fail to perform such services and/or repair obligations or shall refuse to
comply with any of the provisions of the Prime Lease insofar as they materially
affect Sublessee's occupancy of the Subleased Premises, Sublessor shall, at the
written request of Sublessee, use commercially reasonable, good faith efforts to
cause Landlord to so comply but without any obligation to incur any cost,
expense, liability or obligation whatsoever. Sublessor shall be under no
liability to Sublessee in the event of the failure by Landlord to supply any
services, unless the same is due to the wrongful act or the wrongful failure to
act (where action is required hereunder) of Sublessor.

     (b) Sublessor shall provide (1) standard heating and air-conditioning
("HVAC") service to the (x) Office Premises from 7 A.M. to 7 P.M. on Business
Days, (y) Lab Space 24 hours per day provided that night temperature set-back
shall be provided after 7 PM and on non- Business Days, (z) Unfinished Space in
the same manner provided to the Lab Space upon Sublessee's completion of the
Alterations to the Unfinished Space in accordance with plans approved by
Sublessor therefor; (2) Uninterruptible Power Supply and emergency power
(collectively the "EMERGENCY POWER") to the Subleased Premises provided that no
Event of Default has occurred and to the extent that it currently exists within
the Subleased Premises (i.e. Sublessee shall have the right, upon approval of
plans therefor by Sublessor, to connect to the existing panels for the Emergency
Power, but shall not create any new panels for such service); (3) hot and cold
water to the Subleased Premises for ordinary office and bathroom use; (4)
natural gas to the Lab Space and Unfinished Space for ordinary laboratory use;
(5) deionized water to the Lab Space and Unfinished Space for ordinary
laboratory use and (6) ordinary laboratory vacuum system ("VACUUM SYSTEM") to
the Lab Space and Unfinished Space for ordinary laboratory use.

                                       16
<PAGE>

     (c) Sublessor shall maintain, repair and replace, if necessary the HVAC
system, Vacuum System, fire alarm and elevator servicing the Subleased Premises
and shall maintain the common areas of the interior of the Building, at
Sublessor's expense (as part of the Fixed Operating Expense Charge) unless any
repairs, maintenance or replacements are due to Sublessee's negligence or
Sublessee's alterations in which case Sublessee shall pay, as additional rent,
Sublessor's cost and expense for such repair or maintenance or replacement.
Notwithstanding anything to the contrary herein, Sublessor shall not be
obligated to upgrade or make any additions to the HVAC system, Emergency Power
or Vacuum System and Sublessee shall only use such systems within their design
specifications. Sublessee shall also use the Vacuum System with traps and other
protection devices so as to prevent the contamination of the Vacuum System
piping and equipment with any chemical. If contamination of the Vacuum System
occurs, Sublessee shall promptly decontaminate same or replace the component of
the system contaminated at Sublessee's sole cost and expense (or shall pay the
cost thereof to Sublessor if Sublessor elects, in its sole discretion, to
perform such decontamination and/or replacement), and Sublessor reserves the
right, in addition to any other rights or remedies Sublessor may have, to
discontinue providing the Vacuum System or any other service provided to
Sublessee if Sublessee fails to use such systems or services in the manner
described herein.

     (d) Sublessor shall not be liable in any way to Sublessee for any failure,
defect or interruption of any service, utility or other system to be supplied by
Sublessor, including without limitation the Emergency Power, except if
attributable to the gross negligence or willful misconduct of Sublessor, nor
(except as otherwise provided in this Sublease) shall there be any allowance to
Sublessee or diminution of rental value, nor shall the same constitute an actual
or constructive eviction of Sublessee, in whole or in part, or relieve Sublessee
of from any of its Sublease obligations. In addition, in no event (either
through indemnity or otherwise) shall Sublessor be liable to Sublessee for any
consequential, punitive or other damages.

     (e) Sublessee shall provide all cleaning and janitorial services to the
Subleased Premises, including but not limited to the removal of biohazardous
waste as referred to in Section 34 of this Sublease, at Sublessee's sole costs
and expense, to the reasonable satisfaction of Sublessor. Sublessee shall keep
its Premises clean and use the same cleaning service utilized by the Sublessor
to clean the Building unless otherwise approved in writing by Sublessor. In
addition, Sublessee shall make any non-structural repairs to the Subleased
Premises and the fixtures and appurtenances therein as and when needed to
preserve the Subleased Premises in good order and condition, except for
reasonable wear and tear.

     (f) Notwithstanding anything to the contrary in this Sublease, in the event
that Sublessee is unable to use all or more than 20% of the Subleased Premises
for the ordinary conduct of its business as a result solely of (x) Sublessor's
breach of an obligation under this Sublease to perform repairs or provide
services or (y) disruption in any required services to the Subleased Premises
due solely to Sublessor's negligence or willful misconduct, in each case other
than as result of (i) a fire or other casualty, (ii) breach of this Sublease by
Sublessee or any action or inaction by Sublessee, (iii) breach of the Prime
Lease by Landlord or any action or inaction by Landlord or (iv) any other cause
not within Sublessor's control, and such condition continues for a period in
excess of ten (10) consecutive Business Days after the date of notice from
Sublessee to Sublessor (the "ABATEMENT NOTICE") stating Sublessee's inability to
use all or

                                       17
<PAGE>

more than 20% percent of the Subleased Premises, then, provided Sublessee
vacates and does not use all or such portion of the Subleased Premises, the Base
Rent shall be abated on a per diem basis and in proportion to the portion of the
Subleased Premises not used by Sublessee for the period commencing on the
eleventh (11th) day after Sublessor receives the Abatement Notice, and ending
on the earlier of the date on which (A) Sublessee reoccupies all or a portion of
the Subleased Premises for the ordinary conduct of its business, or (B) such
condition is substantially remedied.

19.  NOTICES

Subject to the provisions of Section 5 hereof, any notice, demand, bill,
invoice, statement or communication which either Sublessor or Sublessee may
desire or be required to give to the other in connection with this Sublease
shall be in writing and shall be deemed to have been sufficiently given or
rendered if delivered by hand (against a signed receipt), or by reputable
overnight courier service (against a signed receipt), or by registered or
certified mail (return receipt requested), to such other party at the following
addresses:

           To Sublessor:      Purdue Pharma, L.P.
                              One Stamford Forum
                              Stamford, CT 06901
                              Attention: Diana Lenkowsky

                              copy to:

                              Herrick, Feinstein, LLP
                              2 Penm Plaza
                              Newark, NJ 07105
                              Attention: Joann B. Birle, Esq.

           To Sublessee:

                Before Sublessee commences business in the Subleased Premises:

                              Amicus Therapeutics, Inc.
                              675 U.S. Highway One
                              North Brunswick, NJ 08902
                              Attention: Ms. Allison Sorokin

                After Sublessee commences business in the Subleased Premises
                at the Subleased Premises:

                              Amicus Therapeautics, Inc.
                              6 Cedar Brook Drive
                              Cranbury, NJ 08512
                              Attention: Ms. Allison Sorokin

                                       18
<PAGE>

                              copy to:

                              Riker, Danzig, Scherer, Hyland & Peretti LLP
                              One Speedwell Avenue
                              Morristown, NJ 079625
                              Attention: Nicholas Racioppi, Jr., Esq.

           To Landlord:       Cedar Brook 10 Corporate Center, L.P.
                              1000 Eastpark Blvd.
                              Cranbury, NJ 08512

                              with a copy to:

                              Stephen J. Edwards, Esq.
                              59 Forrest Road
                              Randolph, NJ 07869

or to such other address(es) as Sublessor or Sublessee (or Landlord, if
applicable) may designate as its new address(es) for such purpose by notice
given to the parties in accordance with the provisions of this Section 19. Any
such bill, invoice, statement, notice or communication shall be deemed to have
been rendered or given on the date when it shall have been delivered (as
evidenced by a signed receipt, or, as the case may be, the date of delivery
shown on the return receipt) or upon refusal to accept delivery. Counsel for
Sublessor and Sublessee may deliver notices on behalf of their respective
clients in connection with this Sublease.

20.  TIME LIMITS.

The time limits set forth in the Prime Lease for the performance of any act or
the making of any payment are, for the purposes of this Sublease, changed so
that the time of Sublessee in a particular case hereunder to do or perform any
act or make any payment shall be three (3) days less than the time of Sublessor
as tenant under the Prime Lease to do so in such case (taking into account the
maximum grace period, if any, relating thereto contained in the Prime Lease).
Each party shall promptly deliver to the other party copies of all notices,
requests or demands which relate to the Subleased Premises or the use or
occupancy thereof after receipt of same from Landlord.

21.  BROKERAGE.

Sublessor and Sublessee warrant and represent to each other that in connection
with this Sublease, they have dealt with no brokers except Triad Properties,
Inc., ("TRIAD") Calloway Commercial ("CALLOWAY") and Cushman and Wakefield of
New Jersey ("CW") (collectively, the "BROKER"). Sublessor and Sublessee shall
indemnify, defend and hold the other harmless (including the payment of
attorney's fees) from any claim of any broker that Sublessor or Sublessee had,
or is alleged to have had, dealings with concerning this Sublease other than the
Broker Sublessor shall pay Triad and CW any amounts to which Broker is entitled
in connection with this Sublease, pursuant to a separate written agreement, and
Triad shall pay to

                                       19
<PAGE>

Calloway any amounts to which Calloway is entitled in connection with this
Sublease, pursuant to a separate written agreement.

22.  SURRENDER OF SUBLEASED PREMISES; HOLDING OVER.

     (a) Sublessor and Sublessee recognize that the damage to Sublessor
resulting from any failure by Sublessee to timely surrender possession of the
Subleased Premises may be substantial, may exceed the amount of the Base Rent
and additional rent theretofore payable hereunder, and will be impossible to
accurately measure. Sublessee therefore agrees that if possession of the
Subleased Premises is not surrendered to Sublessor on or before the Expiration
Date, in addition to any other rights or remedies Sublessor may have hereunder
or at law or in equity, Sublessee shall:

          (i) pay to Sublessor for each month (or any portion thereof) during
which Sublessee holds over in the Subleased Premises after the Expiration Date,
a sum equal to the greater of (i) two times (2x) the aggregate of the Base Rent
(as defined in the Prime Lease) and additional rent payable under the Prime
Lease for the last full calendar month of the term thereunder, or (ii) two times
(2x) the fair market rental value of the Subleased Premises for such month (as
reasonably determined by Sublessor);

          (ii) be liable to Sublessor for (A) any payment or rent concession
which Sublessor may be required to make to any sublessee obtained by Sublessor
for all or any part of the Subleased Premises (a "NEW SUBLESSEE") in order to
induce such New Sublessee not to terminate its lease by reason of the
holding-over by Sublessee, and (B) the loss of the benefit of the bargain if any
New Sublessee shall terminate its lease by reason of the holding-over by
Sublessee;

          (iii) be liable to Sublessor for, and indemnify, defend and hold
Sublessor harmless from and against, any and all claims, actions, and suits by
any New Sublessee and any and all costs, expenses (including attorneys' fees and
expenses), losses, damages, liabilities, and obligations Sublessor may incur in
connection therewith; and

          (iv) be liable to Sublessor for, and indemnify, defend and hold
Sublessor harmless from and against, any and all claims, actions, suits, costs,
expenses (including attorneys' fees and expenses), losses, damages, liabilities,
and obligations Sublessor may incur under or in connection with the Prime Lease
by reason of the holding-over by Sublessee.

     (b) No holding-over by Sublessee, nor the payment to Sublessor of the
amounts specified above, shall operate to extend the Term hereof. Nothing herein
contained shall be deemed to permit Sublessee to retain possession of the
Premises after the Expiration Date, and no acceptance by Sublessor of payments
from Sublessee after the Expiration Date shall be deemed to be other than on
account of the amount to be paid by Sublessee in accordance with the provisions
of this Section. If Sublessee does hold over, Sublessor may exercise any and all
rights under this Sublease and/or as may exist at law and/or in equity
(including, without limitation, resort to summary proceedings) to obtain
possession of the Subleased Premises.

                                       20
<PAGE>

     (c) The obligations of Sublessee under this Section 22 shall survive the
expiration or termination of the Term.

23.  CAPTIONS.

The captions in this Sublease are used for convenience and reference only and
are not to be taken as part of this Sublease or to be used in determining the
intent of the parties or otherwise interpreting this Sublease.

24.  SUCCESSORS AND ASSIGNS.

This Sublease shall be binding upon and inure to the benefit of Sublessor and
Sublessee and their respective successors and permitted assigns.

25.  SECURITY DEPOSIT

     (a) Simultaneously with the execution and delivery of this Sublease,
Sublessee has deposited (the "SECURITY DEPOSIT") with Sublessor the sum of Two
Hundred Sixty-Seven Thousand Three Hundred Thirty-Eight Dollars ($267,338) to be
held during the Term as security for the payment of the Base Rent, additional
rent and all other sums of money payable by Sublessee under this Sublease, and
for the faithful performance of all other covenants and agreements of Sublessee
under this Sublease. The Security Deposit shall be returned to Sublessee
(subject to the application thereof to any unpaid "SECURED OBLIGATION" as
hereinafter defined) within thirty (30) days after the expiration date of this
Sublease. Said Security Deposit be held in a non-segregated, non-interest
bearing account.

     (b) Notwithstanding anything to the contrary set forth herein and subject
to the terms and conditions of this Article 25, if Sublessee fails to commence
construction and/or thereafter diligently continue and complete construction of
the Unfinished Space in accordance with the plans approved therefor by Sublessor
within nine (9) months after the Commencement Date, the Security Deposit shall
be increased on the nine month anniversary of the Commencement Date (the
"SECURITY INCREASE DATE") to Eight Hundred and Two Thousand Thirteen Dollars
($802,013) and such amount shall be deemed to be the Security Deposit hereunder.
The failure by Sublessee to provide such increase in the Security Deposit shall
be deemed to be a material breach of the terms of this Sublease and an Event of
Default.

     (c) If an Event of Default shall occur hereunder, in addition to all of
Sublessor's right and remedies set forth in this Sublease, within ten (10) days
after notice by Sublessor, Sublessee shall immediately restore the Security
Deposit to the full amount of the Security Deposit.

     (d) Sublessee's Federal Identification Number is (omitted).

     (e) If an Event of Default shall occur and be continuing, Sublessor may,
subject to the terms and conditions hereinafter set forth, apply the whole or
any part of the Security Deposit (i) toward the payment of any Base Rent or any
item of additional rent due under this Sublease as to which Sublessee is then in
default beyond any applicable notice, cure and/or grace period and (ii)

                                       21
<PAGE>

toward any sum which Sublessor may expend or may be required to expend by reason
of Sublessee's default, beyond any applicable notice, cure and/or grace period,
in respect of any of the terms, covenants and conditions of this Sublease (the
obligations of Sublessee set forth in the foregoing clauses (i) and (ii) being
referred to collectively herein as the "SECURED OBLIGATIONS"). If Sublessor
applies or retains any part of the proceeds of the Security Deposit, Sublessee,
upon demand by Sublessor, shall deposit with Sublessor the amount so applied or
retained so that Sublessor shall have the full Security Deposit on deposit as
security for the Secured Obligations, at all times during the Term.

     (f) In lieu of the cash security deposit, Sublessee may at any time during
the Term deliver to Sublessor and shall thereafter maintain in effect a clean,
irrevocable, non-documentary and unconditional letter of credit, in the form
attached hereto as EXHIBIT E (the "LETTER OF CREDIT") issued by and drawable
upon any commercial bank, trust company, national banking association or savings
and loan association with offices for banking and drawing purposes in the State
of New Jersey (the "ISSUING BANK"), which has outstanding unsecured, uninsured
and unguaranteed indebtedness, or shall have issued a letter of credit or other
credit facility that constitutes the primary security for any outstanding
indebtedness (which is otherwise uninsured and unguaranteed), that is then
rated, without regard to qualification of such rating by symbols such as "+" or
"-" or numerical notation, "Aa" or better by Moody's Investors Service and "AA"
or better by Standard & Poor's Ratings Service (and is not on credit-watch with
negative implications), and has combined capital, surplus and undivided profits
of not less than $500,000,000. The Letter of Credit shall (i) name Sublessor as
beneficiary, (ii) be in the amount of the Security Deposit, (iii) have a term of
not less than one (1) year, (iv) permit multiple drawings, (v) be fully
transferable by Sublessor multiple times without the consent of Sublessee and
without the payment of any fees or charges, (vi) be payable to Sublessor or an
authorized representative of Sublessor upon presentation of only the Letter of
Credit and a sight draft and shall not contain as a condition to a draw the
requirement of Sublessor's certification or other statement as to the existence
of Sublessee's default, and (vii) otherwise be in form and content satisfactory
to Sublessor. If upon any transfer of the Letter of Credit, any fees or charges
shall be so imposed, then such fees or charges shall be payable solely by
Sublessee and the Letter of Credit shall so specify. The Letter of Credit shall
provide that it shall be deemed automatically renewed, without amendment, for
consecutive periods of one (1) year each thereafter during the Term through the
date that is at least sixty (60) days after the Expiration Date, unless the
Issuing Bank sends a notice (the "NON-RENEWAL NOTICE") to Sublessor by certified
mail, return receipt requested, not less than sixty (60) days prior to the
then-current expiration date of the Letter of Credit, stating that the Issuing
Bank has elected not to renew the Letter of Credit. Sublessor shall have the
right to draw upon the Letter of Credit (in whole or in part, at Sublessor's
discretion) at any time or times that Sublessor shall, under this Sublease, be
entitled to retain or apply all or any portion of the Security Deposit.
Sublessor also shall have the right, upon receipt of a Non-Renewal Notice, to
draw the full amount of the Letter of Credit, by sight draft on the Issuing
Bank, and shall thereafter hold or apply the cash proceeds of the Letter of
Credit pursuant to the terms of this Section 25. The Letter of Credit shall
state that drafts drawn under and in compliance with the terms of the Letter of
Credit will be duly honored upon presentation to the Issuing Bank at an office
location in the State of New Jersey or the State of Connecticut. The Letter of
Credit shall be subject in all respects to the International Standby Practices
1998, International Chamber of Commerce Publication No. 590. Sublessee shall
cooperate, at

                                       22
<PAGE>

Sublessee's expense, with Sublessor to promptly execute and deliver to Sublessor
any and all modifications, amendments, and replacements of the Letter of Credit,
as Sublessor may reasonably request to carry out the intent, terms and
conditions of this Section 25. If Sublessee is required to increase the Security
Deposit as required in this Section 25, Sublessee may tender to Sublessor a
replacement Letter of Credit for such increased amount and thereupon, Sublessor
shall exchange the Letter of Credit it is then holding for such replacement
Letter of Credit. If Sublessor applies or returns any part of the proceeds to
the Security Deposit, Sublessee, upon demand by Sublessor, shall deposit with
Sublessor the amount so applied or retained in the form of an additional letter
of credit meeting the requirements hereof, or an increase in the amount of the
tetter of credit meeting the requirements hereof so that Sublessor shall have
the full Security Deposit on deposit as security for the Secured Obligations, at
all times during the Term.

     (g) Upon an assignment of the Sublease and assumption of the obligations of
Sublessor by the assignee, Sublessor shall have the right to transfer the cash
Security Deposit or the Letter of Credit, as applicable, to the assignee. With
respect to the Letter of Credit, within ten (10) days after notice from
Sublessor of any such anticipated assignment, Sublessee, at its sole cost, shall
arrange for the transfer of the Letter of Credit to the new sublessor, as
designated by Sublessor in the foregoing notice, or to have the Letter of Credit
reissued in the name of the new sublessor. Sublessee shall look solely to the
new sublessor for the return of such cash Security Deposit or Letter of Credit,
and the provisions of this subsection shall apply to every transfer or
assignment made of the Security Deposit to a new sublessor. Sublessee will not
assign or encumber, or attempt to assign or encumber, the cash Security Deposit
or Letter of Credit, and neither Sublessor nor its successors or assigns shall
be bound by any such actual or attempted assignment or encumbrance.

     (h) Any cash proceeds of the Letter of Credit which are not otherwise
applied or retained by Sublessor as provided in this Section 25 shall be
invested in a non-segregated, non-interest bearing account.

     (i) The foregoing notwithstanding, it shall be an Event of Default under
this Sublease if Sublessee delivers such a Letter of Credit and the Issuing Bank
sends a Non-Renewal Notice to Sublessor, or if for any reason the Letter of
Credit is not renewed in a timely manner during the entirety of the Term, or if
for any reason the Letter of Credit is not maintained by Sublessee in full force
and effect, in the amount of the Security Deposit during the entirety of the
Term.

26.  ACCESS.

     (a) Subject to the terms and provisions of this Sublease and the Prime
Lease, Sublessee shall have access to the Subleased Premises 24 hours per day,
every day of the year.

     (b) Sublessee and Sublessor acknowledge that as of the date of this
Sublease, Sublessor provides certain security services to the Building.
Sublessee will comply with all security procedures from time to time implemented
by Sublessor, including, without limitation, requirements that any person
entering the Building sign in and/or present satisfactory identification at the
concierge desk and that deliveries be made to a secured freight entrance.
Nothing herein shall impose any obligation on the part of Sublessor to supply or
to cause to be

                                       23
<PAGE>

supplied such security services, or any other security services. Sublessor shall
maintain, or cause to be maintained the current level of security offered by
Sublessor in the Building including the operation of the current front desk
service in the lobby of the Building.

     (e) Sublessor shall have the right, from time to time, to adopt reasonable
rules and regulations with respect to Sublessor's operation and maintenance of
the Building including, without limitation, rules governing access to the
Building.

27.  INTENTIONALLY OMITTED.

28.  PERFORMANCE OF OBLIGATIONS OF LANDLORD UNDER THE PRIME LEASE/OTHER.

Notwithstanding anything to the contrary in this Sublease, Sublessor and
Sublessee agree as follows:

     (a) Sublessee shall not in any event have any rights in respect of the
Subleased Premises greater than Sublessor's rights to such space under the Prime
Lease.

     (b) Any obligation of Sublessor which is contained in this Sublease
(including, without limitation, any obligation for the providing of services,
performance of repairs, or otherwise) by the incorporation by reference of the
provisions of the Prime Lease may be observed or performed
by Sublessor using commercially reasonable efforts to cause Landlord under the
Prime Lease to observe and/or perform the same, and Sublessor shall have a
reasonable time to use such reasonable efforts to so do; and, notwithstanding
any provision to the contrary, as to obligations contained in this Sublease by
the incorporation by reference of the provisions of the Prime Lease, Sublessor
shall not be required to make any payment or perform any obligation, and
Sublessor shall have no liability to Sublessee for any matter whatsoever, except
for Sublessor's obligation to pay the rent and additional rent due under the
Prime Lease and for Sublessor's obligation to use commercially reasonable
efforts where required by this Sublease, upon request of Sublessee, to cause the
landlord under the Prime Lease to observe and/or perform its obligations under
the Prime Lease.

     (c) Sublessor shall not be responsible for any failure or interruption, for
any reason whatsover, except Sublessor's gross negligence or intentional
wrongful act, of any of the services or facilities that may be appurtenant to or
supplied at the Building by the Landlord under the Prime Lease or otherwise,
and no failure to furnish, or interruption of, any such services or facilities
shall give rise to any (i) abatement, diminution or reduction of Sublessee's
obligations under this Sublease, (ii) constructive eviction, whether in whole or
in part, or (iii) liability on the part of Sublessor.

     (d) Sublessee and Sublessor hereby release the other or anyone claiming by,
through or under the other under this Sublease and the Prime Lease and the
Landlord or anyone claiming by, through or under the Landlord under the Prime
Lease by way of subrogation or otherwise to the extent that Sublessor released
the Landlord under the Prime Lease and/or the Landlord under the Prime Lease was
relieved of liability or responsibility pursuant to the provisions of the Prime
Lease, and Sublessee will cause its insurance carriers to include any clauses or
endorsements in

                                       24
<PAGE>
favor of Sublessor and the Landlord under the Prime Lease which Sublessor is
required to provide pursuant to the provisions of the Prime Lease, or Sections
13 and 15(a)(ii) of this Sublease.

      (e) In any instance when Sublessor's consent or approval is required under
this Sublease, Sublessor's refusal to consent to or approve any matter or thing
shall be deemed reasonable if, inter alia, such consent or approval has not been
obtained from the Landlord under the Prime Lease. In the event that Sublessee
shall seek the approval by or consent of Sublessor and Sublessor shall fail or
refuse to give such consent or approval, Sublessee shall not be entitled to any
damages for any withholding or delay of such approval or consent by Sublessor,
it being intended that Sublessee's sole remedy shall be an action for injunction
or specific performance and that said remedy of an action for injunction or
specific performance shall be available only in those cases where Sublessor
shall have expressly agreed in writing not to unreasonably withhold or delay its
consent.

      (f) If for any reason whatsoever the term of the Prime Lease shall
terminate prior to the expiration date of this Sublease, this Sublease shall
thereupon be terminated and Sublessor shall not be liable to Sublessee by reason
thereof. Upon such termination, the obligations of Sublessor and Sublessee
(other than the obligation of Sublessee for the payment of any monies then owing
to Sublessor and such other obligations that are expressly made to be effective
upon the termination of this Sublease as are set forth in the Lease and
incorporated herein by reference and/or as are set forth in this Sublease) shall
cease, except that the parties shall remain liable for any obligations incurred
prior to any such termination date for any matter occurring prior to such date.

      (g) If Sublessee shall at any time fail to make any payment or perform any
other obligation of Sublessee hereunder, then Sublessor shall have the right,
but not the obligation, after three (3) days' notice to Sublessee, or without
notice to Sublessee in the case of any emergency or if such failure would be a
default under the Prime Lease, and without waiving or releasing Sublessee from
any obligations of Sublessee hereunder, to make such payment or perform such
other obligation of Sublessee in such manner and to such extent as Sublessor
shall deem necessary, and in exercising any such right, to pay any incidental
costs and expenses, employ attorneys, and incur and pay reasonable attorneys'
fees. Sublessee shall pay to Sublessor upon demand all sums paid by Sublessor
and all incidental costs and expenses of Sublessor in connection therewith,
together with interest thereon at the Late Charge as defined in the Prime Lease
from the date of the making of such expenditures.

29. SUBLESSEE'S SINGLE RIGHT OF FIRST OFFER

      (a) Sublessor shall offer to sublease to Sublessee (the "ROFO OFFER"), one
time only, on the terms set forth in this Section 29, the vacant, unfinished
space remaining on the first floor chemistry wing of the Building, as more
particularly identified on the floor plan which is attached hereto and made a
part hereof as EXHIBIT D (the "ROFO SPACE"), upon the commencement by Sublessor
of active negotiations to sublease the ROFO Space to a third party. For purposes
hereof, the term "active negotiations" shall be deemed to mean the exchange of
term sheets and/or phone calls and/or other communications with a third party
(or a broker for

                                       25
<PAGE>

such third party) regarding the leasing of the ROFO Space to such third party.
Sublessor shall provide Sublessee with written notice (the "ROFO NOTICE") of the
initiation of Sublessee's ROFO Offer.

            (i) The Base Rent payable for the ROFO Space shall be the per square
foot rental then applicable to the Unfinished Space under this Sublease.

            (ii) Sublessee's proportionate share for the ROFO Space shall be
calculated accordingly under the terms of this Sublease with respect to
obligations under Section 4 of this Sublease.

            (iii) The term of the ROFO Space shall be coterminous with the Term
of this Sublease as same may be earlier terminated.

            (iv) Sublessee shall accept the ROFO Space in its "as-is" condition
on the ROFO Space Commencement Date (as hereinafter defined), and Sublessor
shall not be required to perform any work in the ROFO Space, provide any rent
abatement or any other rent concessions, make any contributions, or render any
services to make the ROFO Space ready for Sublessee's use or occupancy.

            (v) On the ROFO Space Commencement Date, the Subleased Premises
shall be deemed to include the ROFO Space for all purposes of this Sublease and
except as set forth in this Section 29, the subleasing of the ROFO Space shall
be upon all of the other then applicable terms, covenants and conditions
contained in this Sublease with respect to the Subleased Premises.

      (b) If Sublessee chooses to accept the ROFO Offer in accordance with the
provisions of this Article, Sublessee shall notify Sublessor in writing within
seven (7) days of the date of the ROFO Notice that Sublessee will accept the
ROFO Offer. TIME SHALL BE OF THE ESSENCE with respect thereto. Sublessee agrees
that if it accepts the ROFO Offer, it shall be bound by and subject to the terms
stated therein. The ROFO Space Commencement Date shall be the date which is
seventeen (17) days after the date of the ROFO Notice.

      (c) Promptly after the acceptance of the ROFO Offer, (i) the parties shall
execute, upon the request of either party, any amendment or other documentation
reasonably requested to reflect Sublessee's acceptance of the ROFO Offer and the
inclusion of the ROFO Space within the Subleased Premises. Notwithstanding the
foregoing, Sublessee agrees that failure or omission to execute such
documentation shall not effect the inclusion of the ROFO Space within the
Subleased Premises.

      (d) If Sublessee does not timely accept or fails to timely accept the ROFO
Offer for any reason whatsoever, the ROFO Offer shall be deemed null and void
and of no force or effect, and Sublessor shall be entitled to Sublease such ROFO
Space to others at such rental and upon such terms and conditions as Sublessor
in its sole discretion may determine. Sublessee shall, within five (5) days
after Sublessor's request therefor, deliver an instrument in form reasonably

                                       26
<PAGE>

satisfactory to Sublessor confirming the aforesaid waiver of the specifically
made ROFO Offer, but no such instrument shall be necessary to make the
provisions hereof effective.

      (e)Notwithstanding anything to the contrary contained in this Section 29,
Sublessor shall not be obligated to make the ROFO Offer to Sublessee, Sublessee
shall have no right to sublease the ROFO Space, and Sublessor shall have the
right to Sublease the ROFO Space to a third party (i) if and for as long as a
default shall then exist under this Sublease beyond any applicable notice, grace
or cure periods; or (ii) if there shall have been a termination, cancellation or
surrender of this Sublease or a surrender of all or any portion of the Subleased
Premises; or (iii) if Sublessee is not fully occupying the Subleased Premises;
or (iv) once Sublessor subleases the ROFO Space to any other third party in
accordance with the provisions of this Section 29. In addition to and not in
limitation of the foregoing, if any third party desires to sublease the ROFO
Space together with any other space in the Building (whether or not such space
is contiguous), then the provisions of this Section 29 shall be deemed null,
void and of no further force or effect, Sublessor shall be under no obligation
to make the ROFO Offer to Sublessee and Sublessee shall have no right whatsoever
to sublease the ROFO Space pursuant to the terms of this Section 29 and the
provisions of this Section 29 shall be deemed automatically terminated.

      (f) Notwithstanding anything to the contrary contained herein, as of the
date which is the 2nd anniversary of the Commencement Date, the provisions of
this Section 29 shall expire and be deemed null, void and of no further force or
effect, and Sublessor shall have no obligation to make the ROFO Offer to
Sublessee and Sublessee shall have no right whatsoever to sublease the ROFO
Space pursuant to the terms of this Section 29.

      (g) Notwithstanding anything to the contrary herein, Sublessor shall have
the right to offer or sublease the ROFO Space or any portion thereof to any of
its affiliates, subsidiaries or other related entities and such offer or
sublease shall not require Sublessor to make the ROFO Offer to Sublessee and
Sublessee shall not have the right to sublease the ROFO Space in the case of
such an offer or sublease.

30. MISCELLANEOUS.

      (a) Sublessor represents that, to the best of its knowledge, the copy of
the Prime Lease attached hereto as EXHIBIT F is a true, full and complete copy
of the Prime Lease (as redacted) and that the Prime Lease is in full force and
effect.

      (b) This Sublease may be executed in multiple counterparts, and each such
counterpart shall be considered an original, but all of which together shall
constitute one and the same instrument.

                                       27
<PAGE>

31. PARKING. Sublesee shall be entitled to its proportionate share of on-site
parking in the surface parking area serving the Building for use by its
employees, customers and invitees on a non-exclusive basis pursuant to the terms
of the Prime Lease. Sublessee acknowledges that Sublessor has no repair,
maintenance or other obligations with regard to the parking area serving the
Building, but Sublessor reserves the right to close off or otherwise alter
sections of the parking area in Sublessor's reasonable discretion.

32. FOOD SERVICE. Provided Sublessee is (i) not in default under the terms of
this Sublease and (ii) occupying substantially all of the Subleased Premises as
subtenant, Sublessor shall provide reasonable, basic food service at the
Building for Sublessee's employees to purchase breakfast and lunch ("SUBLESSOR'S
FOOD SERVICE") and Sublessor, in its sole discretion, shall have the right to
(x) relocate, diminish or otherwise change the currently existing cafeteria in
the Building and or the operations thereof and/or (y) modify the food service in
any manner, from time to time, except that Sublessor will provide Sublessor's
Food Service.

33. SIGNAGE. Provided Sublessee is not in default pursuant to the terms of this
Sublease and Sublessee is occupying substantially all of the Subleased Premises,
Sublessee shall be entitled to install, at its sole expense and subject to the
approval of Landlord pursuant to the terms of the Prime Lease and the approval
of Sublessor, which may be withheld in the Sublessor's sole discretion, a sign
for the purpose of identifying Sublessee, which sign shall be no larger than 24"
x 18"and shall be located under Sublessor's existing sign on the fixed glass
panel adjacent to main the entrance door at the main lobby of the Building.
Additionally Sublessee may install signage on the main entrance door into the
Subleased Premises. This signage shall be collectively no larger than 12" x 24".
All signage shall comply with the terms of the Prime Lease and all Laws. All
signs installed by Sublessee shall be maintained by Sublessee in good condition
and Sublessee shall remove all signs at the end of the Term and repair any
damage caused by such installation, existence of removal.

34. HAZARDOUS MATERIALS; BIO-HAZARDOUS WASTE; ISRA COMPLIANCE.

      (a) In addition to the provisions of Article 12 of the Prime Lease as
incorporated herein by reference pursuant to Paragraph 11(b) of the Sublease,
Sublessee warrants, represents and covenants to Sublessor that Sublessee's use
of the Subleased Premises will at all times comply and conform to all applicable
Laws which relate to the use, transportation, storage, placement, handling,
treatment, discharge, generation, production, existence or disposal
(collectively "USE OR TREATMENT") of any waste, waste products, radioactive
waste, petroleum products, poly-chlorinated biphenyls, asbestos, hazardous
materials as defined under applicable Laws, and any substance which is regulated
by any Laws, statute, ordinance, rule or regulation, and any Bio-Hazardous Waste
(collectively "HAZARDOUS MATERIALS"). Sublessee further covenants that it will
not engage in or permit any of Sublessee's agents, employees, representatives,
contractors, invitees, vendors, licensees sub-subtenants, assignees, or
occupants of the Subleased Premises to engage in any Use or Treatment of any
Hazardous Materials and Bio-Hazardous Waste on or which affects the Office Park,
unless said Use or Treatment complies with and conforms to all Laws relating to
such Hazardous Materials, "BIO-HAZARDOUS WASTE" means any waste, substance or
material (solid, liquid or gaseous) existing, generated,

                                       28
<PAGE>

produced or resulting from any use, storage, research, production or testing of
biological agents, including without limitation, any definition thereof or
reference thereto in applicable Laws.

      (b) At Sublessee's sole liability, risk, cost, and expense, Sublessee
shall provide proper receptacles and containers for all Hazardous Materials and
Bio-Hazardous Waste and shall make such arrangements as shall be necessary,
proper, and/or required for the Use or Treatment or disposal of Sublessee's
Hazardous Material and Bio-Hazardous Waste in strict compliance with all
applicable Laws. Scheduling for the disposal of Sublessee's Hazardous Materials
and Bio-Hazardous Waste shall be reasonably coordinated with Sublessor and
Sublessee shall, upon request by Sublessor, provide Sublessor with all required
documentation evidencing Sublessee's removal and Use or Treatment of all
Hazardous Materials and Bio-Hazardous Waste in compliance with all applicable
Laws. Sublessor assumes no duty, obligation, or liability with respect to
Sublessee's Hazardous Material and Bio-Hazardous Waste and Sublessee shall
indemnify Sublessor and Prime Landlord from all liability arising out of the
existence of Hazardous Materials and Bio-Hazardous Waste which arise during
Sublessee's (or its agents, employees, representatives, contractors, invitees,
vendors, licensees sub-subtenants, assignees or occupants of the Subleased
Premises) use or occupancy of the Subleased Premises including, without
limitation, the use, existence, creation, storage, transportation, or disposal
thereof.

      (c) Promptly upon receipt of any Notice, as hereinafter defined, from any
party, Sublessee shall deliver to Sublessor a true, correct and complete copy of
any written Notice or a true, correct and complete report of any non-written
Notice. Additionally, Sublessee shall notify Sublessor immediately after having
knowledge of any Use or Treatment of Hazardous Material or Bio-Hazardous Waste,
which does not comply with or conform to all Laws relating to such Hazardous
Material or Bio-Hazardous Waste or any Spill, as hereinafter defined, of same in
or affecting the Subleased Premises. "NOTICE" shall mean any note, notice, or
report, which constitutes or alleges, or states facts which could reasonably
result in any of the following:

            (i) any suit, proceeding, investigation, order, consent order,
injunction, writ, award or action related to or affecting or indicating the Use
or Treatment of any Hazardous Material or Bio-Hazardous Waste in or affecting
the Subleased Premises;

            (ii) any spill, contamination, discharge, leakage, release or escape
of any Hazardous Material or Bio-Hazardous Waste in or affecting the Office
Park, whether sudden or gradual, accidental or anticipated, or of any other
nature (hereinafter "SPILL");

            (iii) any dispute relating to Sublessee's or any other party's Use
or Treatment of any Hazardous Material or Bio-Hazardous Waste or any Spill in or
affecting the Office Park;

            (iv) any claims by or against any insurer related to or arising out
of any Hazardous Material or Bio-Hazardous Waste or Spill in or affecting the
Office Park;

            (v) any recommendations or requirements of any governmental or
regulatory authority, insurer or board of underwriters relating to any Use or
Treatment of Hazardous Material or Bio-Hazardous Waste or a Spill in or
affecting the Office Park; or

                                       29
<PAGE>
            (vi) any legal requirement or deficiency related to the Use or
Treatment of Hazardous Material or Bio-Hazardous Waste or any Spill in or
affecting the Office Park.

      (d) In the event that Sublessee or any of Sublessee's agents, employees,
representatives, invitees, vendors, licensees, sub-subtenants, assignees or
other party or entity entering the Office Park on behalf of or at the request of
Sublessee has caused, suffered or permitted, directly or indirectly, any Spill
in or affecting the Office Park, then Sublessee shall promptly and diligently
take all of the following actions:

            (i) notify Sublessor, as provided herein;

            (ii) take all steps necessary or required by (a) the Prime Lease and
(b) the NJDEP or the appropriate governmental or regulatory agency, to clean up
such Spill and any contamination related to the Spill, all in accordance with
the requirements, rules and regulations of gay or federal environmental
department or agency having jurisdiction over the Spill;

            (iii) fully restore the Office Park to its condition prior to the
Spill subject to the requirements of the Prime Lease and any applicable Laws and
as required by the NJDEP,

            (iv) allow Sublessor or its agents and any state or federal
environmental department or agency having jurisdiction thereof to monitor and
inspect all cleanup and restoration related to such Spill; and

            (v) provided Sublessee has not purchased or fails to maintain
environmental insurance liability coverage in the amount of at least One Million
($ 1,000,000) dollars, then if any clean-up or other remedial action is required
of Sublessee under this Section 34 which would cost more than $200,000 to
comply, at the written request of Sublessor, post a bond or obtain a letter of
credit for the benefit of Sublessor (drawn upon a company or bank satisfactory
to Sublessor) or deposit an amount of money in an escrow account under
Sublessor's name upon which bond, letter of credit or escrow Sublessee may draw,
and which bond, letter of credit or escrow shall be in an amount sufficient to
meet all of Sublessee's obligations under this Section 34. Sublessor shall have
the unfettered right to draw against the bond, letter of credit or escrow in its
discretion in the event that Sublessee is unable or unwilling to meet its
obligations under this paragraph or, if Sublessee fails to post a bond or obtain
a letter of credit or deposit such cash as is required herein, then Sublessor,
at Sublessee's cost and expense, may, but shall have no obligation, do so for
the benefit of Sublessee and do those things which Sublessee is required to do
under this Section 34 and Sublessee will reimburse Sublessor for all costs
incurred within ten (10) days of demand.

      (e) Sublessee hereby agrees that it will indemnify, defend, save and hold
harmless Sublessor and Prime Landlord and each of their respective members,
partners, officers, directors, employees and mortgagees (collectively
"INDEMNIFIED PARTIES") against and from, and to reimburse the Indemnified
Parties with respect to, any and all damages, claims, liabilities, losses, costs
and expenses (including, without limitation, reasonable attorneys' fees and
expenses, court costs, administrative costs, costs of appeals and all clean up,
administrative, fines, penalties and enforcement costs of applicable
governmental agencies) which may be incurred by or asserted

                                       30
<PAGE>

against the Indemnified Parties, either directly or indirectly, by reason or
arising out of; (i) the breach of any representation or undertaking of Sublessee
under this Section 34; or (ii) the Treatment of any Hazardous Material or any
Spill caused by or related to Sublessee or any of its agents, employees,
representatives, contractors, invitees, vendors, licensees, sub-subtenants,
assignees or other party occupying the Subleased Premises or entering the Office
Park on behalf of or at the request of Sublessee; or (iii) the presence of any
Hazardous Materials in or upon the Subleased Premises which did not exist in or
upon the Subleased Premises prior to the Commencement Date of this Sublease.
Sublessee shall not be required to indemnify the Indemnified Parties for any
damages referred to herein if such damage results from the presence of any
Hazardous Materials existing in or on the Office Park or Subleased Premises
prior to the Commencement Date of this Sublease (the "PRE-EXISTING MATERIAL")
unless such damage is related to the disturbance or exacerbation of the
Pre-Existing Material or negligence or willful misconduct (which results in the
disturbance or exacerbation of the Pre-Existing Materials) by Sublessee or any
of its agents, employees, representatives, contractors, invitees, vendors,
licensees, sub-subtenants, assignees or other party occupying the Subleased
Premises or entity entering the Office Park on behalf of or at the request of
Sublessee.

      (f) Sublessor shall indemnify Sublessee and its members, partners,
officers, directors, employees against and from any and all damages, claims,
liabilities, losses, costs and expenses (including, without limitation,
reasonable attorneys' fees and expenses, court costs, administrative costs,
costs of appeals and all clean up, administrative, fines, penalties and
eaforcement costs of applicable governmental agencies) which may be incurred by
or asserted against same, either directly or indirectly, by reason of or arising
out of the Treatment of any Hazardous Material or any Spill caused by Sublessor
or any of its agents, employees, representatives, contractors, invitees, or
vendors with respect to the Subleased Premises. Sublessor shall notify Sublessee
of any Spill (of which it has received actual or constructive notice) that
adversely affects the Subleased Premises. Sublessor shall also (i) take all
steps required by the NJDEP to clean up any Spill that adversely affects
Sublessee's use of the Subleased Premises which is caused by Sublessor or any of
its agents, employees, representatives, contractors, invitees, or vendors, or
(ii) use reasonable efforts to have the Prime Landlord or any of Sublessor's
licensees, subtenants or assignees meet their obligations with respect to any
such Spill caused by such entities which adversely affects Sublessee's use of
the Subleased Premises.

      (g) The obligations of Sublessee and Sublessor under this Section 34 shall
survive any termination or satisfaction of this Sublease.

      (h) Sublessee shall comply with ISRA and all regulations promulgated
thereunder from to time and the requirements under the Prime Lease with respect
to the activities of Sublessee at the Subleased Premises including, without
limitation the closing, termination or transfer of any operation or other
activity of the Sublessee. Notwithstanding the foregoing, Sublessee shall
provide the evidence of compliance referred to in Section 12.4 of the Prime
Lease and any other ISRA requirements related to Sublessee's use of the
Subleased Premises at least six (6) months prior to Sublessee's surrender of the
Subleased Premises or any portion thereof. Sublessee hereby represents and
warrants that its NAICS No. is 541710 and that it shall

                                       31
<PAGE>

inform Sublessor of any change in its NAICS number and obtain Sublessor's and
Landlord's consent for any change in the nature of its business to be conducted
in the Subleased Premises.

      (i) Sublessee shall have no responsibility for any ancillary or reporting
costs for ISRA compliance that arise as a result of any action or inaction of
Sublessor, including by way of example but without limitation, termination of
Sublessor's operations, except for such costs for which Sublessee would
otherwise be responsible pursuant to the terms of this Sublease.

35. TEMP LAB LICENSE. Provided Sublessee is not in default under the terms of
this Sublease, Sublessor grants Sublessee a license to use the laboratory space
and access thereto consisting of 1,280 rentable square feet and as depicted on
EXHIBIT C hereto (the "TEMP LAB"), for a term which shall commence upon the
delivery of possession of the Temp Lab to Sublessee (the " TEMP LAB COMMENCEMENT
DATE") and shall end on the date which is the six month anniversary of the Temp
Lab Commencement Date, or such earlier date upon which the Term hereunder may
expire or terminate pursuant to any provision set forth herein (the "TEMP LAB
EXPIRATION DATE") Sublessor estimates that the Temp Lab Commencement Date shall
occur no later than thirty (30) days after the Commencement Date of this
Sublease. Sublessee shall be entitled to use such Temp Lab pursuant to the terms
herein as if such Temp Lab were part of the Subleased Premises, provided however
that Sublessee shall not pay any Base Rent for said license but shall pay $10.50
per rentable square foot of the Temp Lab ($13,440 per annum; $ 1,120 per month)
as additional rent herein (the "TEMP LAB OPERATING EXPENSE CHARGE") subject to
the terms (including without limitation the escalations, in Section 4(a)) of
this Sublease. Commencing on the Commencement Date (and pro-rated for any
partial month), Sublessee shall pay the Temp Lab Operating Expense Charge in
equal monthly installments in advance on the first day of each month (prorated
for any partial month) without setoff or deduction whatsoever.

      (a) Sublessee shall accept the Temp Lab in its "as-is" condition and shall
keep the Temp Lab in good order and repair as if the Temp Lab were part of the
Subleased Premises. Sublessee shall not be entitled to make any alterations or
changes to the Temp Lab. Sublessee shall be entitled to use the fixtures (the
"FIXTURES") in the Temp Lab and shall take good care of the Fixtures at
Sublessee's sole cost and expense. All damage to the Fixtures shall be promptly
repaired by Sublessee at its sole cost and expense.

      (b) The Temp Lab is subject to all the terms and conditions of this
Sublease as if it were part of the Subleased Premises (including without
limitation, Sublessee's insurance requirements pursuant to Section 13 herein),
except as otherwise expressly set forth in this Section 35. Sublessor shall have
the right to enter upon the Temp Lab at any time to inspect the same or for any
other reason.

      (c) Sublessee shall use the Temp Lab solely as a temporary, but customary
science and chemistry laboratory and in compliance with the terms of the
Sublease (including, without limitation, the terms of Section 8), the Prime
Lease, all Laws and any policies and procedures with respect to the use of the
Temp Lab promulgated by Sublessor from time to time. Any policies and procedures
promulgated by Sublessor with respect to Sublessee's use of the Temp Lab shall
be in keeping with Sublessor's then applicable policies and procedures for use
of the

                                       32
<PAGE>

Temp Lab or space similar to the Temp Lab. In no event shall the Temp Lab be
used as a vivarium. Sublessee shall also disclose to Sublessor the existence of
any toxic reagents to be brought into or used within the Temp Lab and
Sublessee's detailed safety precautions with respect to the use, storage and
handling of these reagents. In no event shall Sublessee store, use or bring or
cause to be stored, used or brought into the Temp Lab any "Scheduled" or
controlled substances.

      (d) Sublessee acknowledges and agrees that the privileges granted to
Sublessee hereunder shall merely constitute a license and shall not be deemed to
grant Sublessee a subtenancy, leasehold or other real property interest in the
Temp Lab or any portion thereof. Sublessee shall promptly vacate and remove all
its property from the Temp Lab on the Temp Lab Expiration Date (or sooner
termination of the license granted herein or this Sublease) and repair any
damage to the Temp Lab and/or the Fixtures therein so as to place the Temp Lab
and/or the fixtures therein as closely as possible, in the same condition as
existed as of the Temp Lab Commencement Date, normal wear and tear excepted
Sublessor shall have the right, in addition to all rights or remedies it may
have at law or in equity and to deny Sublessee access to the Temp Lab If
Sublessee fails to properly vacate the Temp Lab on or prior to the Temp Lab
Expiration Date.

36. DAMAGE; DESTRUCTION; CONDEMNATION.

      (a) If all or any part of the Subleased Premises or any other part of the
Building shall be damaged by fire or other casualty or be condemned or taken in
any manner for a public or quasi - public use, then (i) Sublessor shall not be
required by this Sublease to repair, restore or rebuild the same, (ii) the
parties acknowledge that Landlord shall be required to repair, restore or
rebuild the same to the extent provided in the Prime Lease, and (iii) if by
reason of any such fire or other casualty or condemnation Sublessor shall
receive an abatement of rent or additional rent relating directly to the
Subleased Premises, there shall be a corresponding abatement of Base Rent or
additional rent payable hereunder in proportion to the percentage of the
abatement of Base Rent and Additional Rent Sublessor receives under the Prime
Lease in respect of the Subleased Premises.

      (b) If the Prime Lease shall be terminated by either party thereto
pursuant to Article 11 thereof, Sublessor shall promptly deliver written notice
thereof to Sublessee and this Sublease shall terminate on and as of the same
date, without any liability of either party to the other on account thereof

      (c) If the Prime Lease shall terminate or be terminated (by either party
thereto) pursuant to Article 24 thereof, Sublessor shall promptly deliver
written notice thereof to Sublessee and this Sublease shall terminate on and as
of the same date, without liability of either party to the other on account
thereof.

      (d) Except as provided in subsection (g) hereto, this Sublease shall not
terminate by reason of any casualty or condemnation unless the Prime Lease is
terminated by Sublessor or Landlord pursuant to the terms of the Prime Lease.

                                       33
<PAGE>

      (e) If any part of the Building shall be lawfully taken by condemnation or
in any other manner for any public or quasi-public use or purpose and this
Sublease shall not terminate pursuant to Section 36(c) hereof, then

            (i) this Sublease shall continue in full force and effect except as
provided below, and

            (ii) (A) if all of the Subleased Premises shall be so taken, then
this Sublease shall terminate, without liability of either party to the other on
account thereof, and (B) if any part, but not all, of the Subleased Premises
shall be so taken then (i) on the date of such taking this Sublease shall
terminate as to such part of the Subleased Premises, without liability of either
party with respect to such part on account thereof, and (ii) from and after such
date, the rents hereunder shall be reduced pro-rata according to the rentable
area of such part of the Subleased Premises.

      (f) In no event shall Sublessee be entitled to any portion of any award in
any proceeding with respect to any taking and Sublessee hereby assigns to
Sublessor any such portion or Interest which it may have by operation of law,
except that Sublessee may make a claim with respect to the unamortized portion
of its improvements to the Unfinished Space to the appropriate condemning
authority, provided that same does not reduce any award to Sublessor or Prime
Landlord.

      (g) Notwithstanding anything to the contrary herein, but without limiting
Prime Landlord's or Sublessor's rights under the Prime Lease, if during the last
two (2) years of the Term of this Sublease, the Subleased Premises are destroyed
by fire or other casualty which venders at least 1/3 of the floor area of the
Subleased Premises untenantable or unusable for Sublessee's intended use under
this Sublease, Sublessee shall have the right to terminate this Sublease upon
written notice to Sublessor within ten (10) days after the date of such
casualty.

      (h) In case of any termination of this Sublease (in whole or in part)
pursuant to this Section 36, rents shall be adjusted as of the date of
termination, and any prepaid rents shall be refunded.

37. ADDITIONAL LAB GASES. Sublessee at its sole cost and expense, shall have the
right to install supply tanks (the "TANKS") for the distribution of carbon
dioxide (CO(2)) gas and nitrogen gas to the Lab Space, Temp Lab and Unfinished
Space. The Tanks shall be located solely within the Premises in a location to be
approved by Sublessor in it's sole discretion. The Tanks shall be connected to
the existing piping within the Premises and Sublessee shall not make any
alterations to said existing piping without Sublessor's prior consent which
shall not be unreasonably withheld. Sublessee shall make and maintain all
connections to the existing piping in compliance with all Laws. The size and use
of such Tanks shall be in compliance with all Laws and subject to the approval
of Sublessor. Sublessee shall maintain such Tanks and connections in good order
and repair to avoid any leakage or other seepage from occurring with respect to
such Tanks and shall indemnify Landlord, pursuant to the terms of Section 12
herein, for any claim, liabilities, damages, losses costs and expenses arising
from or related to Sublessee's use, maintenance, storage or other handling of
the Tanks, the gasses within them and the connections

                                       34
<PAGE>

thereto. Sublessor shall have no liability to Sublessee with respect to
Sublessee's use of the Tanks or additional lab gasses.

                            [SIGNATURE PAGE FOLLOWS]

                                       35
<PAGE>

      IN WITNESS WHEREOF, this Sublease has been executed as of the day and year
first above written.

WITNESS:                                 SUBLESSOR:

                                         PURDUE PHARMA L.P.

By: ______________________               By: /s/ Diana Lenkowsky
                                             ------------------------
                                             Name: Diana Lenkowsky
                                             Title: Vice President

WITNESS:                                 SUBLESSEE:
                                         AMICUS THERAPEUTICS, INC.

By: ______________________               By: /s/ John F. Crowley
                                             ------------------------
                                             Name: John F. Crowley
                                             Title: CEO

                                       36<PAGE>
                                                                    EXHIBIT 10.7

                              AMENDED AND RESTATED
                              EMPLOYMENT AGREEMENT

            THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this "Amended
Agreement"), dated as of April 28, 2006, between AMICUS THERAPEUTICS, INC., a
Delaware corporation having an office at 6 Cedar Brook Drive, Cranbury, New
Jersey 08512 (the "Company"), and JOHN F. CROWLEY, an individual residing at 15
Leonard Court, Princeton, NJ 08540 ("Employee").

                                    PREAMBLE

            WHEREAS, effective January 6, 2005, the Company and the Employee
entered into that certain Employment. Agreement (the "Original Agreement") and
this Amended Agreement amends and restates the Original Agreement;

            WHEREAS, since January 17, 2005, the Employee has served as the
Chief Executive Officer of the Company, and the Company desires to continue the
employment of Employee in the capacities of President and Chief Executive
Officer and Employee desires to continue such service, all pursuant to the
terms and conditions hereinafter set forth;

            NOW, THEREFORE, in consideration of the mutual covenants contained
herein, and for ether good and valuable consideration, the sufficiency and
receipt whereof is hereby acknowledged, the parties agree as follows:

      SECTION 1. Definitions. Unless otherwise defined herein, the following
terms shall have the following respective meanings:

            "Cause" means for any of the following reasons: (i) willful or
deliberate misconduct by Employee that materially damages the Company; (ii)
misappropriation of Company assets; (iii) Employee's conviction of or a plea of
guilty or "no contest" to, a felony; or (iv) any willful disobedience of the
lawful and unambiguous instructions of the Board of Directors of the Company;
provided that the Board of Directors has given Employee thirty (30) days written
notice of such disobedience or neglect and Employee has failed to cure such
cause.

            "Change in Control Event" means any of the following (i) any person
or entity (except for a current stockholder) becomes the beneficial owner of
greater than 50% of the then outstanding voting power of the Company; (ii) a
merger or consolidation with another entity where the voting securities of the
Company outstanding immediately before the transaction constitute less than a
majority of the voting power of the voting securities of the Company or the
surviving entity outstanding immediately after the transaction, or (iii) the
sale or disposition of all or substantially all of the Company's assets.

            "Common Stock" means the common stock of the Company; par value $.01
per share.

            "Effective Date" means January 17, 2005.

            "Good Reason" means (i) a change in Employee's position with the
Company or its successor that materially reduces his title, duties, reporting
obligations or level of responsibility; or (ii) the relocation of the Company or
its successor greater than 25 miles away from the then current location of the
Company's principal offices, without the consent of Employee.

<PAGE>

      SECTION 2. Employment.

            Subject to the terms and conditions of this Amended Agreement,
Employee is hereby employed by the Company to serve as its President and Chief
Executive Officer. Employee accepts such employment, and agrees to discharge all
of the duties normally associated with said positions, to faithfully and to the
best of his abilities perform such other services consistent with his position
as a senior executive officer as may from time to time be assigned to him by the
Board of Directors of the Company and to devote all of his business time, skill
and attention to such services. Notwithstanding the foregoing, however, Employee
may serve on the boards of directors of other companies, and in civic, cultural,
philanthropic and professional organizations so long as such service does not
detract from the performance of Employee's duties hereunder, such determination
to be made by the Board of Directors in its sole discretion. Employee may
continue service as an officer, U.S. Navy Reserve, and any periods of active
duty service shall not result in any reduction in compensation or benefits
payable to Employee under Section 3 of this Amended Agreement. At all times
during which Employee remains President and Chief Executive Officer of the
Company, Employee shall serve as a member of the Company's Board of Directors
and, at the request of the Company's Board of Directors, as an officer or
director of any Company affiliate, in each case without additional remuneration
therefor.

      SECTION 3. Compensation and Benefits.

            3.1 Base Salary. During the Employment Term (as defined in Section 5
hereof), the Company shall pay Employee a salary at the annual rate of $400,000
or such greater amount as the Company's Board of Directors may from time to time
establish pursuant to the terms hereof (the "Base Salary"). Such Base Salary
shall be reviewed annually and may be increased, but not decreased, by the Board
of Directors of the Company in its sole discretion. The Base Salary shall be
payable in accordance with the Company's customary payroll practices for its
senior management personnel.

            3.2 Bonus. During the Employment Term, Employee shall be eligible to
participate in the Company's bonus programs in effect with respect to senior
management personnel. Employee shall be eligible to receive an annual target
bonus of up to 50% of the Base Salary in cash (the "Bonus").

            3.3 Benefits

                  (a) Benefit Plans. During the Employment Term, Employee may
participate, on the same basis and subject to the same qualifications as other
senior management personnel of the Company, in any benefit plans (including
health and medical insurance of Employee, Employee's spouse and Employee's
dependents) and policies in effect with respect to senior management personnel
of the Company, including any stock option plan.

                  (b) Reimbursement of Expenses. During the Employment Term, the
Company shall pay or promptly reimburse Employee, upon submission of proper
invoices in accordance with the Company's normal procedures, for all reasonable
out-of-pocket business, entertainment and travel expenses incurred by Employee
in the performance of his duties hereunder.

                  (c) Medical Expenses. Effective May 1, 2006, the Company shall
secure and maintain during the Employment Term, at the expense of the Company,
an Executive Medical Reimbursement Contract with First Rehabilitation Life
Insurance Company of America, or a plan with another insurer providing
substantially similar benefits, covering Employee, Employee's spouse and
Employee's dependents (the "Health Plan Contract"). The Company shall reimburse
Employee for all out-of-pocket expenses (the "Out of Pocket Expenses") incurred
by Employee, Employee's spouse and

                                      - 2 -
<PAGE>

Employee's dependents for ail "medical expenses" (as such term is defined in the
Internal Revenue Code of 1986, as amended (the "Code") and as interpreted by
federal courts) not otherwise reimbursed or covered under; (i) the Health Plan
Contract; (ii) any other existing health care insurance policy maintained by the
Company covering Employee, Employee's spouse and Employee's dependents; or (iii)
COBRA payments required to continue any health care insurance policies, if any,
currently covering Employee, Employee's spouse and Employee's dependents as of
the date of this Agreement, The amount of Out of Pocket Expenses to be
reimbursed to Employee: (x) shall be "grossed-up" such thai the Company shall
pay all Federal and state income taxes which the Employee shall incur as a
consequence of the Company's reimbursement of the Out of Pocket Expenses and the
grossing-up thereof; and (y) shall not exceed $220,000 (before grossing-up as
provided in (x) above). Employee shall submit reimbursement requests and the
Company shall reimburse Employee within the same framework and timeframe as
employees submit their business expense reimbursement requests. The
reimbursement of Out of Pocket Expenses for Employee's spouse and Employee's
dependents shall continue for a period of twelve (12) months following
Employee's death or Disability (as defined in Section 5.5).

                  (d) Vacation. During the Employment Term, Employee shall be
entitled to up to four (4) weeks of vacation in accordance with the policies of
the Company applicable to senior management personnel from time to time.

                  (e) Withholding. The Company shall be entitled to withhold
from amounts payable or benefits accorded to Employee under this Agreement all
federal, state and local income, employment and other taxes, as and in such
amounts as may be required by applicable law.

      Section 4. Employment Term. The term of this Agreement (the "Employment
Term") shall sad on the close of business on the first anniversary of the date
of this Amended Agreement. The Employment Term shall be automatically extended
for additional one-year periods (each a "Renewal Period") unless, at least sixty
(60) days prior to the end of the expiration of the Employment Term, Employee
notifies the Board of Directors or the Board of Directors notifies Employee that
the notifying party does not wish to extend such Employment Term. Employee's
employment hereunder shall be coterminous with the Employment Term, unless
sooner terminated as provided in Section 5.

      Section 5. Termination; Severance Benefits.

            5.1 Generally. Either the Board of Directors of the Company or
Employee may terminate Employee's employment hereunder, for any reason, at any
time prior to the expiration of the Employment Term, upon sixty (60) days prior
written notice to the other party. Upon termination of Employee's employment
hereunder for any reason, Employee shall be deemed simultaneously to have
resigned as a member of the Board of Directors of the Company and from any other
position or office he may at the time hold with the Company or any of its
affiliates.

            5.2 Termination by Employee.

                  (a) No Reason. If, prior to the expiration of the Employment
Term, Employee voluntarily resigns from his employment, other than for Good
Reason, Employee shall (i) receive no further Base Salary or Bonus hereunder,
other than accrued and unpaid Base Salary through and including the effective
date of termination of his employment with the Company (the "Accrued
Compensation") and (it) cease to be covered under or be permitted to participate
in or receive any of the benefits described in Section 3.3 hereof (provided,
however, that Employee shall be entitled to receive any benefits under Section
3.3 hereof to the extent such benefits have accrued through and including the
effective date of termination of his employment with the Company).

                                      - 3 -
<PAGE>

                  (b) Good Reason. If, prior to the expiration of the Employment
Term, Employee terminates his employment hereunder for Good Reason, Employee
shall be entitled to receive an amount equal to Employee's then current Base
Salary, payable over eighteen (18) months in accordance with the Company's
customary payroll practices for its senior management personnel (the "Severance
Payment"), plus an amount equal to 1.5 (one and one-half) times the target Bonus
for the year in which such termination occurs (such amount being payable on the
effective date of the termination of Employee's employment with the Company),
plus any of the benefits under Section 3.3 hereof if and to the extent such
benefits have accrued through and including such effective date of termination
(such accrued benefits being payable on such effective date of the termination).
In addition, the vesting of the Options shall accelerate with respect to the
twelve (12) month period beginning on the date of Employee's effective date of
termination, and Employee shall continue to be covered under or be permitted to
participate in or receive the benefits described in paragraphs (a) and (c) of
Section 3.3 hereof for the period of time during which the Severance Payment is
payable to Employee.

            5.3 Termination by the Company.

                  (a) Without Cause. If, prior to the expiration of the
Employment Term, the Company terminates Employee's employment hereunder without
Cause or if the Board of Directors of the Company gives written notice pursuant
to Section 4 hereof notifying Employee that the Board of Directors does not wish
to extend the Employment Term, then Employee shall be entitled to receive the
Severance Payment commencing upon the effective date of the termination of
Employee's employment with the Company, shall be entitled to receive (on such
effective date of termination) benefits under Section 3.3(b) hereof to the
extent such benefits have accrued through and including such effective date of
termination, shall continue to be covered under or be permitted to participate
in or receive the benefits described in paragraphs (a) and (c) of Section 3.3
hereof for the period of time during which the Severance Payment is payable to
Employee, and shall be paid (on such effective date of termination) an amount
equal to 1.5 (one and one-half) times the target Bonus for the year in which
such termination occurs. In addition, the vesting of the Options shall
accelerate with respect to the twelve (12) month period beginning on the date of
Employee's effective date of termination and Employee shall continue to be
covered under or be permitted to participate in or receive applicable Benefits
for the period of time during which the Severance Payment is payable to
Employee.

                  (b) For Cause. If, prior to the expiration of the Employment
Term, the Company terminates Employee's employment hereunder for Cause, Employee
shall (i) receive no further base Salary or Bonus hereunder, other than Accrued
Compensation which shall be payable on the effective date of the termination of
Employee's employment with the Company and (ii) cease to be covered under or be
permitted to participate in or receive any of the benefits described in Section
3.3 hereof; provided, however, that (A) Employee shall be entitled to receive
(on such effective date of termination) any benefits under Section 3.3 hereof to
the extent such benefits have accrued through and including such effective date
of termination, and (B) if Employee is terminated for Cause hereunder solely as
a result of being convicted of a felony, which conviction is ultimately reversed
on appeal or pardoned, Employee shall be deemed to have been terminated without
Cause as of the date of such termination for Cause.

            5.4 Termination in Connection with a Change in Control Event. If,
prior to the expiration of the Employment Term, Employee resigns for Good Reason
or the Company terminates Employee's employment hereunder without Cause, or if
the Board of Directors of the Company gives written notice pursuant to Section 4
hereof notifying Employee that the Board of Directors does not wish to extend
the Employment Term, in each case within: (a) three (3) months prior to, or (b)
twelve (12) months following, the occurrence of a Change in Control Event,
Employee shall be entitled to receive an amount equal to two (2.0) times
Employee's then current Base Salary, payable over twenty-four (24)

                                      - 4 -
<PAGE>

months, commencing upon the effective date of the termination of Employee's
employment with the Company, in accordance with the Company's customary payroll
practices for its senior management personnel (the "Change in Control Severance
Payment"), plus an amount equal to two (2.0) times the target Bonus for the year
in which such resignation or termination occurs (such amount being payable on
such effective date of termination), plus any of the benefits under Section 3.3
hereof if and to the extent such benefits have accrued through and including
such effective date of termination (such accrued benefits being payable on such
effective date of the termination). In addition, the Options shall vest in full,
any vesting requirements for any restricted stock grants shall lapse and
Employee shall continue to be covered under or be permitted to participate in or
receive the benefits described in paragraphs (a) and (c) of Section 3.3 hereof
for the period of time during which the Change in Control Severance Payment is
payable to Employee.

            5.5 Termination upon Death or Disability. Employee's employment
hereunder shall termination upon death of Employee. The Company may terminate
Employee's employment hereunder in the event Employee is disabled and such
disability continues for more than 180 days. "Disability" shall be defined as
the inability of Employee to render the services required of him, with or
without a reasonable accommodation, under this Agreement as a result of physical
or mental incapacity. In the event of death or termination by the Company due to
disability of Employee, the Company shall continue to pay to Employee or
Employee's estate, the compensation required under Section 3, for a period of
twelve (12) months.

            5.6 Release Required. In order to receive the Severance Payment or
the Change in Control Severance Payment, and other benefits under Section 5
hereof, including the acceleration of vesting of the Options, Employee must
execute and deliver to the Company a release, the form and substance of which
are acceptable to the Company.

      Section 6. Federal Excise Tax.

            6.1 General Rule. Employee's payments and benefits under this
Agreement and all other arrangements or programs related thereto shall not, in
the aggregate, exceed the maximum amount that may be paid to Employee without
triggering golden parachute penalties under Section 280G of the Code, and the
provisions related thereto with respect to such payments. If Employee's benefits
must be cut back to avoid triggering such penalties, Employee's benefits will be
cut back in the priority order Employee designates or, if Employee fails to
promptly designate an order, the priority order designated by the Company. If an
amount in excess of the limit set forth in this Section is paid to Employee,
Employee must repay the excess amount to the Company upon demand, with interest
at the rate provided in Code Section 1274(b)(2)(B). Employee and the Company
agree to cooperate with each other reasonably in connection with any
administrative or judicial proceedings concerning the existence or amount of
golden parachute penalties on payments or benefits Employee receives.

            6.2 Exception. Section 6.1 shall apply only if it increases the net
amount Employee would realize from payments and benefits subject to Section 6.1,
after payment of income and excise taxes by Employee on such payments and
benefits.

            6.3 Determinations. The determination of whether the golden
parachute penalties under Code Section 280G and the provisions related thereto
shall be made by counsel chosen by Employee and reasonably acceptable to the
Company. All other determinations needed to apply this Section 6 shall be made
in good faith by the Company's independent auditors.

                                      - 5 -
<PAGE>

      Section 7. General.

            7.1 Confidentiality and Non-Competition Agreement. Employee and the
Company hereby ratify and re-affirm that certain Confidentiality and
Non-Competition Agreement dated January 26, 2005 (the "Confidentiality
Agreement").

            7.2 No Conflict. Employee represents and warrants that he has not
entered, nor will he enter, into any other agreements that restrict his ability
to fulfill his obligations under this Agreement and the Confidentiality
Agreement.

            7.3 Governing Law. This Agreement shall be construed, interpreted
and governed by the laws of the State of New Jersey, without regard to the
conflicts of law rules thereof.

            7.4 Binding Effect. This Agreement shall extend to and be binding
upon Employee, his legal representatives, heirs and distributes and upon the
Company, its successors and assigns regardless of any change in the business
structure of the Company.

            7.5 Assignment. Neither this Agreement nor any of the rights or
obligations hereunder shall be assigned or delegated by any party without the
prior written consent of the other party.

            7.6 Entire Agreement. Except for any stock option or stock award
agreements between the parties, this Agreement contains the entire agreement of
the parties with respect to the subject matter hereof. No waiver, modification
or change of any provision of this Agreement shall be valid unless in writing
and signed by both parties.

            7.7 Waiver. The waiver of any breach of any duty, term or condition
of this Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

            7.8 Severability. If any provision of this Agreement shall be
unenforceable in any jurisdiction in accordance with its terms, the provision
shall be enforceable to the fullest extent permitted in that jurisdiction and
shall continue to be enforceable in accordance with its terms in any other
jurisdiction and the validity, legality and enforceability of the remaining
provisions contained herein shall not be affected thereby.

            7.9 Conflicting Agreements. In the event of a conflict between this
Agreement and any other agreement between Employee and the Company, the terms
and provisions of this Agreement shall control.

            7.10 Resolution of Disputes. Any claim or controversy arising out
of, or relating to, this Agreement, other than with respect to the
Confidentiality Agreement, between Employee and the Company (or any officer,
director, employee or agent of the Company), or the breach thereof, shall be
settled by arbitration administrated by the American Arbitration Association
under its National Rules for the Resolution, of Employment Disputes. Such
arbitration shall be held in New Jersey (or in such other location as the
Company may at the time be headquartered). The arbitration shall be conducted
before a three-member panel. Within fifteen (15) days after the commencement of
arbitration, each party shall select one person to act as arbitrator and the two
selected shall select a third arbitrator within ten (10) days of their
appointment.

            If the arbitrators selected by the parties are unable or fail to
agree upon the third arbitrator, the third arbitrator shall be selected by the
American Arbitration Association and shall be a

                                      - 6 -
<PAGE>

member of the bar of the State of New Jersey actively engaged in the practice of
employment law for at least ten years. The arbitration panel shall apply the
substantive laws of the State of New Jersey in connection with the arbitration
and the New Jersey Rules of Evidence shall apply to all aspects of the
arbitration. The award shall be made within thirty days of the closing of the
hearing. Judgment upon the award rendered by the arbitrators(s) may be entered
by any Court having jurisdiction thereof.

            7.11 Notices. All notices pursuant to this Agreement shall be in
writing and shall be sent by prepaid certified mail, return receipt requested or
by recognized air courier service addressed as follows:

                  (i)   If to the Company to:

                        Amicus Therapeutics, Inc.
                        6 Cedar Brook Drive
                        Cranbury, New Jersey 08512

                  (ii)  If to Employee to:

                        John F. Crowley
                        15 Leonard Court
                        Princeton, New Jersey 08540

or to such other addresses as may hereinafter be specified by notice in writing
by either of the parties, and shall be deemed given three (3) business days
after the date so mailed or sent.

            7.12 Counterparts. This Agreement may be executed in counterparts,
each of which shall be deemed an original but all of which shall together
constitute one and the same agreement.

                            [Signature Page Follows]

                                      - 7 -
<PAGE>

  IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first above written.

                                        /s/ John F. Crowley
                                        --------------------------------
                                        JOHN F. CROWLEY

                                        AMICUS THERAPEUTICS, INC.

                                        By:  /s/ P. Sherrill Neff
                                             ---------------------------
                                        Name: P. SHERRILL NEFF
                                        Title: CHAIRMAN, COMPENSATION COMMITTEE

                                      - 8 -

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}]]