Document:

Exhibit 10.33

                                 LEASE AGREEMENT

THIS Lease dated effective April 28, 2000 is by and between:

                  CASS MILL NURSERIES, INC. a company incorporated under
                  the laws of the State of Ohio, having an office at 6905 Middle
                  Ridge Road, Madison, Ohio, 44052.

                  ("Landlord")

AND

                  NAPRO BIOTHERAPEUTICS, INC., a company incorporated under the
                  laws of the State of Delaware, having an office at 6304 Spine
                  Road, Unit A, Boulder, Colorado, 80301

                  ("Tenant")

                                   BACKGROUND

A.       The Landlord is the registered owner of lands located in City of
Madison, County of Lake and State of Ohio.

B.       The Landlord has agreed to lease the lands to the Tenant on the terms
and conditions set out below.

                                   AGREEMENTS

         For good and valuable consideration, the receipt and sufficiency of
which each party acknowledges, the parties covenant and agree as follows:

                                     PART 1

                                   DEFINITIONS

1.1      Defined Terms.  In this Lease:

         (a)      "Basic Rent" has the meaning set out in paragraph 3.1;
         (b)      "Lands"  means ten (10) acres,  as described  in Schedule 1,
                  subject to amendment from time to time in accordance with
                  paragraph 2.3;
         (c)      "Removed Lands" has the meaning given it in paragraph 2.3;
         (d)      "Term" means the term of fifteen (15) years  commencing on
                  April 10, 2000  ("Commencement  Date") and ending on April
                  10, 2015.
         (e)      "Lease Year" means any term of one (1) year commencing on any
                  anniversary date of the Effective Date of this Lease and
                  continuing for one (1) year from that date.

                                     PART 2

                                 DEMISE AND TERM

2.1 Demise. The Landlord leases the Lands to the Tenant for the Term, and the
Tenant leases the Lands from the Landlord for the Term, subject to the terms of
this Lease.

2.2 Early Termination. If the Tenant wishes to terminate this Lease prior to the
expiration of the Term, it may do so provided the Tenant gives written notice of
termination to the Landlord sixty (60) days prior to the end of any Lease Year.

2.3 Lands. The Tenant shall have the right to decrease the acreage comprising
the Lands provided that the Tenant gives written notice sixty (60) days prior to
the end of any Lease Year, such notice to include a revised Schedule 1
reflecting that portion of the Lands to be removed for the purposes of this
Lease ("Removed Lands");

                                     PART 3

                                 RENT AND TAXES

3.1 Rent. During the Term the Tenant will pay to the Landlord, except as
provided in 2.3 above, at such place as the Landlord designates in writing, and
without deduction, set off or abatement whatsoever, basic rent of ____________
("Basic Rent") for each year, payable annually in advance. On the effective date
of any deletion of Removed Lands in accordance with 2.3 above the Basic Rent
will abate in the proportion that the Removed Lands bears to the whole of the
Lands.

3.2      Property  Taxes.  The  Landlord  will  pay  promptly  when  due  all
taxes,  rates,  duties,  levies  and assessments imposed or assessed against the
Lands or upon the Landlord in respect of the Lands.

3.3 Business Taxes. The Tenant will pay promptly when due all taxes, rates,
duties, levies and assessments which have been attracted by the Tenant's
improvements and equipment (if any), and all corporate, income, profit or excess
profit taxes, sales tax or business tax by whatever name called assessed upon
the Tenant.

                                     PART 4

                      USE OF PREMISES AND TENANT COVENANTS

4.1 Permitted Use. The Tenant may use the Premises for the purpose of yew tree
or other plantation and the Tenant will not use the Lands or permit them to be
used for any other purpose without the Landlord's prior written consent which
may not be withheld unreasonably.

4.2      Tenant Covenants.  Subject to paragraph 4.3, the Tenant agrees as
follows:

         (a)      to occupy the Lands in compliance with all laws (including
                  without limitation all environmental laws), ordinances, rules
                  and regulations of governmental authorities. Tenant hereby
                  reserves the right to contest enforcement of any such
                  governmental regulations.

         (b)      to keep the Lands in a clean and orderly condition; and

         (c)      not to commit or permit to be committed waste upon the Lands.

4.3 Cass Mill Nurseries, Inc. Notwithstanding any provision in this Lease, the
Landlord acknowledges and agrees that to the extent Landlord or any other
affiliate of the Landlord is performing management services on behalf of the
Tenant, the Tenant will not be responsible for any act of Landlord or such
affiliate that is in violation of the covenants in this Lease.

4.4 Quiet Enjoyment. Subject to the observance and performance by the Tenant of
all its obligations under this lease, the Tenant may use the Lands in accordance
with the provisions of this Lease.

                                     PART 5

                             INSURANCE AND INDEMNITY

5.1 Tenant's Insurance. The Tenant at its expense will provide and maintain in
force during the Term commercial general liability insurance concerning the
Lands and the Tenant's business of not less than five million dollars
($5,000,000) or in such other amount as may be reasonably required by the
Landlord; the insurance will include, without limitation, liability for personal
injury or death, contractual liability, property damage and contingent
employer's liability. Tenant is entitled to provide such coverage under the
terms of its general corporate insurance and does not have to provide and
maintain a separate insurance policy covering the Lands.

5.2 Landlord's Right to Insure. If the Tenant does not provide or maintain in
force the insurance required under this Lease or provide proof of the insurance
when requested by the Landlord, the Landlord may take out the necessary
insurance and pay the premiums, and the Tenant will pay to the Landlord as
additional rent the amount of such premium on the next succeeding rental payment
date.

5.3 Acts Conflicting with Insurance. The Tenant will not do or permit to be done
any act or thing which may render void or conflict with any policy of insurance,
by which the Lands are insured. If any such policies are cancelled or reduced,
or threatened to be cancelled or reduced, by reason of any act or omission of
the Tenant, the Landlord will have the right at its option to place such
insurance at the expense of the Tenant and to remedy the circumstances which may
prevent the issuance of the insurance. If the premium paid in respect of any
policy is increased by any act or omission of the Tenant, the Tenant will pay to
the Landlord at the Landlord's option on the next succeeding rental payment date
the amount by which the premium has been increased as additional rent. All of
the remedies of the Landlord in this paragraph may be taken without limiting or
affecting any other right or remedy in this Lease.

5.4 Indemnity. The Tenant will indemnify the Landlord and save it harmless from
and against all claims, actions, damages, liabilities, costs and expenses in
connection with loss of life, personal injury or damage to property arising from
any occurrence on the Lands, or use of the Lands, or occasioned wholly or in
part by an act or omission of the Tenant, its officers, employees, agents,
customers, contractors or other invitees to the extent that such act is arising
out of the negligence, willful conduct, act, or omission of the Tenant, its
officers, employees, agents, customers, contractors, or other invitees. The
indemnification obligation under this Part 5.4 shall not apply to any
contributory negligence of the indemnified party. The provisions of this
paragraph will survive the expiry or sooner termination of this Lease.

5.5 Force Majure. In the event that either party"s performance of its
obligations under this Lease shall be prevented by any cause beyond its
reasonable control, including without limitation acts of God, acts of
government, shortage of material, accident, fire, delay or destruction of means
of transport or other disaster, provided that the affected party shall have used
its reasonable efforts to avoid or remove the cause of such nonperformance, then
such affected party"s performance shall be excused and the time for performance
shall be extended for the period of delay or inability to perform due to such
occurrence. The affected party shall continue performance under this Lease using
its best efforts as soon as such cause is removed.

                                     PART 6

                 MAINTENANCE, REPAIRS, ALTERATIONS AND FIXTURES

6.1 Tenant's Maintenance and Repairs. Subject to paragraph 4.3, the Tenant will
at its cost: reimburse the Landlord within ninety (90) days for the repair of
any damage caused to any part of the Lands caused by or through the wilful act,
negligence or omission of the Tenant, its officers, employees, agents,
customers, contractors or other invitees; and immediately discharge any liens
and other encumbrances filed at any time against the Lands by reason of any act
of the Tenant, its officers, employees, agents, customers, contractors or other
invitees, and if the Tenant fails to do so the Landlord may at its option pay
into Court the amount required to obtain a discharge of any such lien and any
amount so paid including costs and disbursements on a solicitor client basis
will be payable as additional rent; the Tenant acknowledges that the Landlord
may file a notice of interest in the applicable land title office under the
provisions of the Builders Lien Act or any legislation in amendment or
substitution thereof evidencing that the Landlord is not responsible for the
Tenant's improvements (if any); the Tenant reserves the direct right to contest
the filing of such lien; and the Tenant agrees to cooperate with the Landlord in
respect of the same and, if necessary, to execute and deliver all other
instruments and take any actions necessary to give effect to the same.

                                       3
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6.2 Alterations, Installations and Fixtures. The Tenant may make alterations,
repairs, installations, removals, improvements or install any fixtures or
leasehold improvements in or about the Lands with the Landlord's prior written
consent, such consent not to be withheld unreasonably. Any alterations, repairs,
installations, removals, improvements or leasehold improvements in or about the
Lands made by the Tenant shall remain the property of the Tenant upon the
expiration or termination of this Lease.

6.3 Removal of Leasehold Improvements. Upon expiry or earlier termination of
this Lease, in spite of the provisions of paragraph 6.2 the Tenant will, at its
expense, remove from the Lands all yew trees, leasehold improvements, fixtures,
furniture and equipment.

                                     PART 7

                            ASSIGNMENT AND SUBLETTING

7.1 Landlord's Consent. The Tenant may assign, mortgage, or encumber this Lease
in whole or in part, sublease all or any part of the Lands or permit them to be
used or occupied by any other person (collectively "Transfer") at its sole
discretion without the prior written consent of the Landlord.

7.2 Assignment by Landlord. If the Landlord sells or otherwise transfers an
interest in the Lands or this Lease, in whole or in part, to the extent that the
transferee is responsible for compliance with the obligations of the Landlord
under this Lease, the Landlord without further written agreement will be
released from all of its obligations in this Lease other than the indemnity
provisions of this Lease applicable to the Landlord and the covenants of the
Landlord hereunder. So long as the Culture Agreement between Landlord and Tenant
is still effective, the Landlord may not sell or otherwise transfer an interest
in the Land or this Lease, in whole or in part, unless the transferee third
party agrees in writing to comply with the obligations of the Landlord under
this Lease.

                                     PART 8

                                STATUS STATEMENT

8.1 Status Statement. Once per Calendar Year, as requested by the Landlord, its
mortgagee, or the Tenant, the Landlord or Tenant will provide within thirty (30)
days thereafter a certificate in writing as to the status of the Lease,
including whether it is in full force and effect, is modified or unmodified,
confirming the rental payable and the state of accounts between the Landlord and
Tenant, the existence or non-existence of defaults, and any other matters
pertaining to this Lease as may be reasonably required.

                                     PART 9

                                     DEFAULT

9.1      Tenant's Default.  If:

         (a)      the Tenant fails to pay any rent or any other amount owing
                  under this Lease within thirty (30) days following written
                  notice of demand by Landlord;

         (b)      the Tenant fails to observe or perform any of its other
                  obligations under this Lease and the Tenant has not, within
                  thirty (30) days after notice from the Landlord specifying the
                  default, cured the default or, if the cure reasonably requires
                  a longer period, if the Tenant has not commenced to cure the
                  default within the thirty (30) day period and thereafter does
                  not diligently pursue the cure of such default;

the Landlord, in addition to any other right or remedy, may do any or all of the
following:

         (c)      re-enter and remove all persons and property from the
                  Premises, and the property may be removed and stored
                  elsewhere. Landlord must first give service of notice to
                  Tenant before any re-entry occurs. Landlord acknowledges that
                  failure to serve notice before re-entry is grounds for
                  trespass and liability for losses.

         (d)      terminate this Lease and all of the Tenant's rights under it;
and

9.2      Bankruptcy.  If:

         (a)      a receiver is appointed to control the conduct of the business
                  of the Tenant on or from the Premises;

         (b)      the Tenant  becomes  bankrupt or insolvent or takes the
                  benefit of any  legislation  in force for bankrupt or
                  insolvent debtors;

         (c)      proceedings  are instituted  for the winding-up or termination
                  of the corporate existence of the Tenant;

         (d)      the Lease or the Tenant's assets are taken under a writ of
execution or security instrument;

then this Lease, at the option of the Landlord, may be immediately terminated
according to 9.1 (d) herein.

9.3      Right to Relet.

         (a)      If the Landlord re-enters, it may at its option, without
                  terminating the Tenant's rights, relet the Lands, or any part,
                  as the Tenant's agent for such period of time and at such rent
                  and on such other terms as the Landlord wishes;

         (b)      Upon reletting, all rent and monies received by the Landlord
                  will be applied, first to the payment of indebtedness other
                  than rent due from the Tenant to the Landlord, second to the
                  payment of costs and expenses of the reletting including
                  brokerage and legal expenses, and third to the payment of rent
                  due and unpaid under this Lease. The residue, if any, will be
                  applied to the payment of future rent as it becomes due and
                  payable.

         (c)      If at any time the rent received from the reletting is less
                  than the rent to be paid under this Lease, the Tenant will pay
                  the deficiency to the Landlord to be calculated and paid
                  annually.

9.4 Re-entry. No re-entry or entry will be construed as an election by the
Landlord to terminate this Lease unless a written notice of intention to
terminate is given to the Tenant.

9.5 Landlord Perform Tenant's Covenants. If Tenant fails to perform an
obligation relating to an event of default existing under this Lease, the
Landlord may perform the obligation and may enter the Lands without notice and
do everything the Landlord considers reasonably necessary. The Tenant will pay
as rent all costs and expenses incurred by the Landlord. The Landlord will not
be liable for any loss or damages resulting from negligence or otherwise
resulting from such action.

9.6 Damages. If the Landlord terminates this Lease then in addition to other
remedies, it may recover from the Tenant all costs incurred and damages suffered
including the cost of recovering the Premises, professional fees and
disbursements paid, and the worth at the time of termination of the excess, if
any, of (i) the amount of rent and charges equivalent to rent for the remainder
of the term over (ii) the then reasonable rental value of the Premises for the
remainder of the Term calculated on a present value basis, all of which amounts
will be immediately due and payable.

                                     PART 10

                               ACCESS BY LANDLORD

10.1 Access and Entry. The Landlord and its agents may enter the Lands at any
reasonable time with the prior written or oral consent of the Tenant to examine
them and show them to a prospective purchaser or mortgagee.

                                     PART 11

                                  MISCELLANEOUS

11.1 Holding Over. If the Tenant holds over after the expiration of the term,
and the Landlord accepts rent, there is no tacit renewal of this Lease, and the
Tenant will be considered to be occupying the Lands as a Tenant from month to
month at a rental, payable in advance on the first day of each month, equal to
one hundred and twenty five percent (125%) of one twelfth of the annual
installment of Basic Rent payable by the Tenant for the last lease year of the
Term, and otherwise all terms and conditions of this Lease are applicable.

11.2 Relationship of Parties. Nothing contained in this Lease shall be construed
so as to operate or to place any party hereto in the relationship of employee or
agent or joint venturer or legal representative of the other party. It is hereby
expressly agreed and acknowledged that each of the parties hereto is an
independent contracting party which does not have the authority or power for or
on behalf of the other party hereto to enter into any contract to incur debts,
to accept money, to assume any obligations or to make any warranties or
representations whatsoever.

11.3 Interpretation. Where the context requires, the singular includes the
plural and vice versa, and the masculine, feminine and neuter include each
other. If two or more individuals or entities compose the Tenant, the liability
of each under this Lease is joint and several.

11.4     Registration.  This Lease will not be  registered  in the Land Title
Office and the  Landlord  will not be required to deliver it in registrable
form.

11.5 No Waiver. The waiver by either Party of a breach or a default of any
provision of this Lease by the other Party shall not be construed as a waiver of
any succeeding breach of the same or any other provisions, nor shall any delay
or omission on the part of either Party to exercise or avail itself of any
right, power or privilege that it has, or may have hereunder, operate as a
waiver of any right, power or privilege by such Party.

11.6 Notices. Any notice to be given under this Lease will be considered to be
given to the Tenant if delivered by hand to Kai Larson, VP, General Counsel at
6304 Spine Road, Unit A, Boulder, Colorado, 80301, or if mailed by prepaid
registered or certified post to the named individual at the given address. Any
notice to be given under this Lease will be considered to be given to the
Landlord if delivered by hand to the Landlord or a responsible representative of
the Landlord at 6905 Middle Ridge Road, Madison, Ohio 44052, or if mailed by
prepaid registered post to the same address.

11.7     Time of Essence.  Time will be of the essence in this Lease.

11.8 Remedies. The parties hereto shall be entitled to enforce their rights
under this Lease specifically, to recover damages and costs (including
reasonable attorneys" fees) caused by any breach of any provision of this Lease
and to exercise all other rights existing in their favour. The parties hereto
agree and acknowledge that money damages may not be an adequate remedy for any
breach of the provisions of this Lease and that any party may in its sole
discretion apply to any court of law or equity of competent jurisdiction for
specific performance and/or other injunctive relief (without posting any bond or
deposit) in order to enforce or prevent any violations of the provisions of this
Lease.

11.9 Severance. Whenever possible, each provision of this Lease shall be
interpreted in such manner as to be effective and valid under applicable law,
but if any provision of this Lease is held to be invalid, illegal or
unenforceable in any respect under any applicable law or rule in any
jurisdiction, such invalidity, illegality or unenforceability shall not affect
any other provision or any other jurisdiction, but this Lease shall be reformed,
construed and enforced in such jurisdiction as if such invalid, illegal or
unenforceable provision had never been contained herein.
11.10 Complete Lease. This Lease and the Culture Agreement of July 26, 1997
which have been executed by Landlord and Tenant embody the complete agreement
and understanding among the parties hereto with respect to the subject matter
hereof and supersede and preempt any prior understandings, agreements or
representations by or among the parties, written or oral, which may have related
to the subject matter hereof in any way.

11.11 No Modification. Any modification, alteration, change or variation in any
provision of this Lease shall be only made in a writing that refers to this
Lease executed by both parties.

11.12 Successors. Except as otherwise provided herein, this Lease shall bind and
inure to the benefit of an be enforceable by the Landlord, and the Tenant, and
their respective heirs and assigns.

11.13 Governing Law. This Lease shall be governed by and construed in accordance
with the laws of the State of Ohio, without giving effect to any choice of law
or conflict of law provision or rule (whether State of Ohio or any other
jurisdiction) that would cause the application of the law of any jurisdiction
other than the State of Ohio.

11.14 Interpretation. Headings and captions in this Lease are for ease of
reference only and shall not be used to interpret this Lease. The language of
this Lease shall be deemed to be the language mutually chosen by the parties and
no rule of strict construction shall be applied against either Party hereto.

11.15 Counterparts. This Lease shall become binding when any one or more
counterparts hereof, individually or taken together, shall bear the signatures
of each of the parties hereto. This Lease may be executed in any number of
counterparts, each of which shall be deemed an original as against the party
whose signature appears thereon, but all of which taken together shall
constitute but one and the same instrument.

IN WITNESS WHEREOF, the parties hereto have duly executed this Lease as of the
date first written above.

CASS MILL NURSERIES, INC.
By:

John Cassell
Authorized Signatory

NAPRO BIOTHERAPEUTICS, INC.
By:

Gordon Link
VP, Chief Financial Officer
Authorized SignatoryExhibit 10.34

          FORM OF SUBSCRIPTION AGREEMENT INCLUDING REGISTRATION RIGHTS

NaPro BioTherapeutics, Inc.
6304 Spine Road, Unit A
Boulder, Colorado  80301

Ladies and Gentlemen:

         The undersigned subscriber ("Subscriber") hereby tenders this
Subscription Agreement (this "Agreement") in accordance with and subject to the
terms and conditions set forth herein:

         1.   Subscription.

                  1.1.Subscriber hereby subscribes for and agrees to purchase
the number of shares of common stock, par value $.0075 per share (the "Common
Stock"), of NaPro Biotherapeutics, Inc., 6304 Spine Road, Unit A Boulder,
Colorado 80301, a Delaware corporation (the "Company"), indicated on the
signature page attached hereto at the purchase price set forth on such signature
page (the "Purchase Price"). Subscriber has made payment by wire transfer of
funds in accordance with instructions from the Company in the full amount of the
Purchase Price of the Common Stock for which Subscriber is subscribing (the
"Payment").

                  1.2 This Agreement is part of an offering of up to 2,000,000
shares of Common Stock being conducted by Stonegate Securities, Inc. (the
"Placement Agent") on behalf of the Company (the "Offering"). The Company agrees
that it shall not undertake any other financings involving its Equity Common
Stock (as defined below) on terms more favorable than those in the Offering
until the later of ninety (90) days after the Initial Closing Date or 30 days
after the filing of the Registration Statement (as that term is defined in
Appendix I hereto) covering all of the Common Stock. The term "Equity Common
Stock" as used herein shall mean all capital stock of the Company, plus all
rights, warrants, options, convertible Common Stock or indebtedness,
exchangeable Common Stock or indebtedness, or other rights, exercisable for or
convertible into, directly or indirectly, capital stock of the Company.
Notwithstanding the above, "Equity Common Stock" shall not include any Common
Stock of the Company issued pursuant to (a) any incentive or stock option plan
of the Company approved by the stockholders or the board of directors of the
Company. and (b) that certain Stock Purchase Agreement by and between the
Company and Abbott Laboratories dated June 23, 1999. In the event the Company
shall, during the period beginning on the date of this Agreement and ending the
later of ninety (90) days after the Initial Closing Date or thirty (30) days
after the filing of the Registration Statement, sell any shares of the Company's
common stock or any instruments that can be converted into or otherwise
exchanged for the Company's common stock (the "Subsequent Sale") exercisable at
a price per share (the "Subsequent Purchase Price") of less than $8.75 per
share, the purchase price per Share hereunder shall be adjusted to an amount
equal to the Subsequent Purchase Price, such that the Company shall, within ten
(10) business days of the Subsequent Sale, pay to each Subscriber an amount
equal to the number of Shares times the difference between $8.75 and the
Subsequent Purchase Price.

                  1.3.Subscriber understands that it will not receive a fee
equal to 6% of the gross proceeds from the sale of the Common Stock in this
Offering and a warrant to purchase shares of Common Stock equal to 5% of the
number of shares sold in this Offering up to a maximum of 100,000 shares. In
addition, the Company will reimburse the Placement Agent for its reasonable
out-of-pocket expenses incurred in connection with this Offering.

                  1.4.Subscriber understands that it will not earn interest on
any funds held by the Company prior to the date of closing of the Offering. The
Placement Agent and the Company may hold an initial closing of the Offering (the
"Initial Closing') at any mutually agreeable time. The date of the Initial
Closing is hereinafter referred to as the "Initial Closing Date". The Company
may hold additional interim closings after the Initial Closing provided that the
terms of the Offering are the same for each closing. Any such interim closings
are each hereinafter referred to as an "Additional Closing" and shall occur on
one 0or more dates each hereinafter referred to as an "Additional Closing Date."
The Initial Closing Date and the Additional Closing Dates are each hereinafter
sometimes referred to as a "Closing Date." Upon receipt by the Company of the
requisite payment for all Common Stock to be purchased by the subscribers whose
subscriptions are accepted at the Initial Closing or any Additional Closing, as
applicable, and subject to the satisfaction of certain conditions, the Common
Stock so purchased will be issued in the name of each such subscriber, and the
name of such subscriber will be registered on the stock transfer books of the
Company as the record owner of such Common Stock. The Company will promptly
thereafter issue to each subscriber participating in such closing a stock
certificate for the Common Stock so purchased.

                  1.5.Subscriber hereby agrees to be bound hereby upon (i)
execution and delivery to the Company, in care of the Placement Agent, of the
signature page to this Agreement and (ii) written acceptance on the Initial
Closing Date or an Additional Closing Date, as the case may be, by the Company
and the Placement Agent of Subscriber's subscription, which shall be confirmed
by faxing to the Subscriber the signature page to this Agreement that has been
executed by the Company (the "Subscription").

                  1.6.Prior to acceptance of this Agreement by the Company and
the Placement Agent, Subscriber agrees that the Company and Placement Agent may,
as they mutually agree in their sole and absolute discretion, reduce the
Subscription to any number of shares of Common Stock that in the aggregate do
not exceed the number of shares of Common Stock hereby applied for without any
prior notice to or further consent by Subscriber; provided, however, if any of
Subscriber's Subscription is so reduced, Subscriber may withdraw his entire
Subscription. Subscriber hereby irrevocably constitutes and appoints the
Placement Agent and each officer of the Placement Agent, each of the foregoing
acting singularly, in each case with full power of substitution, the true and
lawful agent and attorney-in-fact of Subscriber, with full power and authority
in Subscriber's name, place and stead to amend this Agreement, including, in
each case, Subscriber's signature page thereto, to effect any of the foregoing
provisions of this Section 1.5.

                  1.7.Subscriber agrees and understands that the principals of
the Placement Agent may purchase Common Stock in this offering for their own
account, and that the Placement Agent has traded Common Stock of the Company
prior to the date of this Agreement.

         2.   Offering Material.

                  2.1.Subscriber represents and warrants that it is in receipt
of and that it has carefully read the following items:

         (a) The Company's definitive proxy statement filed with the SEC on
August 15, 2000;

         (b) The Company's Form 10-K for the year ended December 31, 1999 ("Form
10-K")

         (c) The Company's Form 10-K/A for the year ended December 31, 1999
("Form 10-K/A");

         (d) The Company's Form 10-Qs for the quarters ended March 31, June 30
and September 30, 2000;

         (e) The Company's Form 8-K dated October 31, 2000;

         (f) All other documents filed by the Company with the Commission
subsequent to the Company's Form 10-K/A and prior to the Closing Date; and

         (g) The risk factors for the Company set forth in Appendix II to this
Agreement.

         The documents listed in this Section 2.1 shall be referred to herein as
the "Public Reports."

         3.       Conditions to  Subscriber's Obligations.

                  3.1.The obligation of Subscriber to close the transaction
contemplated by this Agreement (the "Transaction") is subject to the
satisfaction on or prior to the Closing Date of the following conditions set
forth in Sections 3.2 through 3.3 hereof.

                  3.2.The Company  shall have  executed  this  Agreement  and
delivered  the same to the Placement Agent.

                  3.3.The Board of Directors of the Company shall have adopted
resolutions consistent with Section 4.1(d) below in a form reasonably acceptable
to the Placement Agent.

                  3.4.The Placement Agent and its counsel shall have received
copies of all documents and information which it may have reasonably requested
in connection with the Offering.

                  3.5.The Company shall have delivered to Subscribers a legal
opinion in substantially the form attached hereto as Appendix III.

         4.   Representations and Warranties; Covenants; Survival.

                  4.1.The Company  represents  and warrants that, at the date of
this Agreement and at each Closing Date:

                           (a) The Company and each of its subsidiaries is a
                  corporation duly organized, validly existing and in good
                  standing under the laws of its state of incorporation, with
                  all requisite corporate power and authority to carry on the
                  business in which it is engaged and to own the properties it
                  owns, and the Company has all requisite power and authority to
                  execute and deliver this Agreement and to consummate the
                  transactions contemplated hereby. The Company and each of its
                  subsidiaries is duly qualified and licensed to do business and
                  is in good standing in all jurisdictions where the nature of
                  its business makes such qualification necessary, except where
                  the failure to be qualified or licensed would not have a
                  material adverse effect on the business of the Company and its
                  subsidiaries, taken as a whole.

                           (b) Except as described in the Public Reports, there
                  are no legal actions or administrative proceedings or
                  investigations instituted, or to the best knowledge of the
                  Company threatened, against, or that could reasonably be
                  expected to have a material adverse effect on the Company or
                  any subsidiary, any of the Common Stock, or the business of
                  the Company and its subsidiaries.

                           (c) The Company's audited consolidated financial
                  statements as of December 31, 1999, contained in the Form
                  10-K, and its unaudited financial statements as of September
                  30, 2000, contained in the Form 10-Q (the "September 2000
                  10-Q"), including the notes contained therein, fairly present
                  the consolidated financial position of the Company at the
                  respective dates thereof and the results of its consolidated
                  operations for the periods purported to be covered thereby.
                  Such financial statements have been prepared in conformity
                  with generally accepted accounting principles consistently
                  applied with prior periods subject to any comments and notes
                  contained therein. Since September 30, 2000, there has been no
                  material adverse change in the financial condition of the
                  Company from the financial condition stated in such financial
                  statements or change in the capitalization of the Company as
                  set forth in the September 2000 10-Q.

                           (d) The Company, by appropriate and required
                  corporate action, has, or will have prior to the Initial
                  Closing, duly authorized the execution of this Agreement,
                  including Appendix I, and the issuance and delivery of the
                  Common Stock. The Common Stock is not subject to preemptive,
                  antidilution or other rights of any stockholders of the
                  Company and when issued in accordance with the terms of this
                  Agreement and the Certificate of Incorporation of the Company,
                  the Common Stock will be validly issued, fully paid and
                  nonassessable and free and clear of all pledges, liens and
                  encumbrances.

                           (e) Performance of this Agreement and compliance with
                  the provisions hereof will not violate any provision of any
                  applicable law or of the Certificate of Incorporation or
                  Bylaws of the Company, or of any of its subsidiaries, and,
                  will not conflict with or result in any breach of any of the
                  terms, conditions or provisions of, or constitute a default
                  under, or result in the creation or imposition of any lien,
                  charge or encumbrance upon, any of the properties or assets of
                  the Company, or of any of its subsidiaries, pursuant to the
                  terms of any indenture, mortgage, deed of trust or other
                  agreement or instrument binding upon the Company, or any of
                  its subsidiaries, other than such breaches, defaults or liens
                  which would not have a material adverse effect on the Company
                  and its subsidiaries taken as a whole.

                           (f) The Public Reports, taken together, do not
                  contain any untrue statement of a material fact or omit to
                  state a material fact required to be stated therein to make
                  the statements contained therein not misleading.

                           (g) The Company has provided Subscriber with all
                  material public information in connection with the business of
                  the Company and the transactions contemplated by this
                  Agreement, and no representation or warranty made, nor any
                  document, statement, financial statement prepared or
                  furnished, by the Company in connection herewith contains any
                  untrue statement of material fact, or omits to state a
                  material fact necessary to make the statements or facts
                  contained herein or therein not misleading.

                           (h) This Agreement, including Appendix I, has been
                  duly executed and delivered by the Company and constitutes a
                  valid and binding obligation of the Company, enforceable
                  against the Company in accordance with its terms.

                           (i) No registration, authorization, approval,
                  qualification or consent of any court or governmental
                  authority or agency is necessary in connection with the
                  execution and delivery of this Agreement or the offering,
                  issuance or sale of the Shares under this Agreement.

                           (j) The Company has timely filed with the Securities
                  and Exchange Commission (the "Commission") all documents
                  required to be filed by the Company under the Exchange Act of
                  1934, as amended (the "Exchange Act").

                           (k) The Company intends to use the proceeds from the
                  sale of the Shares for working capital and other general
                  corporate purposes. The Company is not now, and after the sale
                  of the Shares under this Agreement and under all other
                  agreements and the application of the net proceeds from the
                  sale of the Shares described in the proceeding sentence will
                  not be, an "investment company" within the meaning of the
                  Investment Company Act of 1940, as amended.

                           (l) Subject to the accuracy of the Subscribers'
                  representations and warranties in Section 7 of this Agreement,
                  the offer, sale, and issuance of the Shares in conformity with
                  the terms of this Agreement constitute transactions exempt
                  from the registration requirements of Section 5 of the
                  Securities Act and from the registration or qualification
                  requirements of the laws of any applicable state or United
                  States jurisdiction.

                           (m) Neither the Company, nor any of its affiliates,
                  nor any person acting on its or their behalf, has directly or
                  indirectly made any offers or sales in any security or
                  solicited any offers to buy any security under circumstances
                  that would require registration under the Securities Act of
                  the issuance of the Shares to the Purchasers. The issuance of
                  the Shares to the Purchasers will not be integrated with any
                  other issuance of the Company's securities (past, current or
                  future) for purposes of the Securities Act or any applicable
                  rules of Nasdaq. The Company will not make any offers or sales
                  of any security (other than the Shares) that would cause the
                  offering of the Shares to be integrated with any other
                  offering of securities by the Company for purposes of any
                  registration requirement under the Securities Act or any
                  applicable rules of Nasdaq.

         5.   Transfer and Registration Rights

                  5.1.Subscriber acknowledges that it is acquiring the Common
Stock for its own account and for the purpose of investment and not with a view
to any distribution or resale thereof within the meaning of the Securities Act
of 1933, as amended (the "Act"), and any applicable state or other securities
laws ("State Acts"). Subscriber further agrees that it will not sell, assign,
transfer or otherwise dispose of any of the Common Stock in violation of the Act
or State Acts and acknowledges that, in taking unregistered Common Stock, it
must continue to bear economic risk in regard to its investment for an
indefinite period of time because of the fact that such Common Stock has not
been registered under the Act or State Acts and further realizes that such
Common Stock cannot be sold unless subsequently registered under the Act and
State Acts or an exemption from such registration is available. Subscriber
further recognizes that the Company is not assuming any obligation to register
such Common Stock except as expressly set forth herein. Subscriber also
acknowledges that appropriate legends reflecting the status of the Common Stock
under the Act and State Acts may be placed on the face of the certificates for
such Common Stock at the time of their transfer and delivery to the holder
thereof. This Agreement is made with Subscriber in reliance upon Subscriber's
above representations.

                  5.2.The Common Stock issued pursuant to this Agreement may not
be transferred except in a transaction which is in compliance with the Act and
State Acts. Except as provided hereafter with respect to registration of the
Common Stock or sale under Rule 144 contemplated in Appendix I, it shall be a
condition to any such transfer that the Company shall be furnished with an
opinion of counsel, which counsel and opinion shall be reasonably satisfactory
to the Company, to the effect that the proposed transfer would be in compliance
with the Act and State Acts.

                  5.3.The Company hereby grants to Subscriber the registration
rights set forth in Appendix I attached hereto. Appendix I is incorporated into,
and made a part of, this Agreement.

                  5.4.Anything in this Section 5 or elsewhere herein to the
contrary notwithstanding, it is understood and agreed by the Company (1) that
Subscriber has not been asked to agree, nor has he agreed, to desist from
purchasing or selling, long and/or short, Common Stock issued by the Company, or
"derivative" Common Stock based on Common Stock issued by, the Company or to
hold the Common Stock purchased from the Company for any specified term; (2)
that past or future open market or other transactions by Subscriber, including
short sales, and specifically including, without limitation, short sales or
"derivative" transactions, before or after the closing of this or future private
placement transactions, may negatively impact the market price of the issuer's
publicly-traded Common Stock; (3) that Subscriber, and counter parties in
"derivative" transactions to which Subscriber is a party, directly or
indirectly, have or may have a "short" position in the common stock of the
Company, and (4) that Subscriber shall not be deemed to have any affiliation
with or control over any arm's length counter-party in any "derivative"
transaction.

         6.   Closing.

                  6.1.The closing of the sale of the Common Stock to Subscriber
shall take place at the offices of the Placement Agent at such time as the
Company and Placement Agent shall mutually agree; provided, however, that in no
event shall such closing occur after November 17, 2000; and provided further
that no Additional Closing shall occur more than two (2) weeks after the Initial
Closing Date.

         7.   Subscriber Representations.  Subscriber hereby represents,
warrants and acknowledges and agrees with the Company and Placement Agent as
follows:

                  7.1.Subscriber has been furnished with and has carefully read
the Public Reports as set forth in Section 2.1 hereto and is familiar with the
terms of the Offering. With respect to individual or partnership tax and other
economic considerations involved in this investment, Subscriber is not relying
on the Company or the Placement Agent (or any agent or representative of any of
them). Subscriber has carefully considered and has, to the extent Subscriber
believes such discussion necessary, discussed with Subscriber's legal, tax,
accounting and financial advisers the suitability of an investment in the Common
Stock for Subscriber's particular tax and financial situation.

                  7.2.Subscriber has had an opportunity to inspect relevant
documents relating to the organization and operations of the Company. Subscriber
acknowledges that all documents, records and books pertaining to this investment
which Subscriber has requested have been made available for inspection by
Subscriber and Subscriber's attorney, accountant or other adviser(s).

                  7.3.Subscriber and/or Subscriber's advisor(s) has/have had a
reasonable opportunity to ask questions of and receive answers and to request
additional relevant information from a person or persons acting on behalf of the
Company concerning the Offering.

                  7.4.Subscriber is not subscribing for the Common Stock as a
result of or subsequent to any advertisement, article, notice or other
communication published in any newspaper, magazine or similar media or broadcast
over television or radio or presented at any seminar.

                  7.5.Subscriber is an "accredited investor" within the meaning
of Rule 501(a) of Regulation D under the Act ("Regulation D"). Subscriber, by
reason of Subscriber's business or financial experience or the business or
financial experience of Subscriber's professional advisers who are unaffiliated
with and who are not compensated by the Company or the Placement Agent or any
affiliate of either of them, directly or indirectly, can be reasonably assumed
to have the capacity to protect Subscriber's own interests in connection with
the transaction. Subscriber further acknowledges that he has read the written
materials provided by the Company.

                  7.6.If Subscriber is a natural person, Subscriber has adequate
means of providing for Subscriber's current financial needs and contingencies,
is able to bear the substantial economic risks of an investment in the Common
Stock for an indefinite period of time, has no need for liquidity in such
investment and, at the present time, could afford a complete loss of such
investment.

                  7.7.Subscriber has such knowledge and experience in financial,
tax and business matters so as to enable Subscriber to use the information made
available to Subscriber in connection with the Offering to evaluate the merits
and risks of an investment in the Common Stock and to make an informed
investment decision with respect thereto.

                  7.8.Subscriber acknowledges that the Common Stock herein
subscribed for has not been registered under the Act or under any State Act.
Subscriber understands further that in absence of an effective Registration
Statement, the Common Stock can only be sold pursuant to some exemption from
registration, such as Rule 144 of the Act, which requires, among other
conditions that the Common Stock must be held for a minimum of one (1) year.

                  7.9.Subscriber recognizes that investment in the Common Stock
involves substantial risks. Subscriber further recognizes that no Federal or
state agencies have passed upon this offering of the Common Stock or made any
finding or determination as to the fairness of this investment.

                  7.10. Subscriber acknowledges that each certificate
representing the Common Stock shall contain a legend substantially in the
following form:

                  THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
                  ACT OF 1933 (THE "SECURITIES ACT") OR UNDER APPLICABLE STATE
                  SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED OR OTHERWISE
                  DISPOSED OF UNLESS REGISTERED UNDER THE SECURITIES ACT AND ANY
                  APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AVAILABLE
                  EXEMPTIONS FROM SUCH REGISTRATION, PROVIDED THAT THE SELLER
                  DELIVERS TO THE COMPANY AN OPINION OF COUNSEL (WHICH OPINION
                  AND COUNSEL ARE SATISFACTORY TO THE COMPANY) SATISFACTORY TO
                  THE COMPANY CONFIRMING THE AVAILABILITY OF SUCH EXEMPTION.
                  INVESTORS SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO BEAR
                  THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE
                  PERIOD OF TIME.

                  7.11. If this Agreement is executed and delivered on behalf of
a partnership, corporation, trust or estate: (i) such partnership, corporation,
trust or estate has the full legal right and power and all authority and
approval required (a) to execute and deliver, or authorize execution and
delivery of, this Agreement and all other instruments executed and delivered by
or on behalf of such partnership, corporation, trust or estate in connection
with the purchase of the Common Stock, (b) to delegate authority pursuant to a
power of attorney and (c) to purchase and hold such Common Stock; (ii) the
signature of the party signing on behalf of such partnership, corporation, trust
or estate is binding upon such partnership, corporation, trust or estate; and
(iii) such partnership, corporation or trust has not been formed for the
specific purpose of acquiring the Common Stock, unless each beneficial owner of
such entity is qualified as an "accredited investor" within the meaning of
Regulation D and has submitted information substantiating such individual
qualification.

                  7.12. If Subscriber is a retirement plan or is investing on
behalf of a retirement plan, Subscriber acknowledges that investment in the
Common Stock poses risks in addition to those associated with other investments,
including the inability to use losses generated by an investment in the Common
Stock to offset taxable income.

                  7.13. Subscriber shall indemnify and hold harmless the Company
and the Placement Agent and each officer, director or control person of any such
entity, who is a party to any action, suit or proceeding, whether civil,
criminal, administrative or investigative, by reason of or arising from any
misrepresentation or misstatement made by Subscriber to the Company or the
Placement Agent in the Subscriber Questionnaire or other document signed and
submitted by Subscriber to the Company or the Placement Agent against losses,
liabilities and expenses actually and reasonably incurred by the Company, the
Placement Agent or any officer, director or control person of any such entity in
connection with such action, suit or proceeding for which the Company, the
Placement Agent, or such officer, director or control person has not otherwise
been reimbursed (including reasonable attorneys' fees, judgments, fines and
amounts paid in settlements approved by Subscriber). As used herein the term
"misrepresentation" includes the supplying of information by Subscriber in
writing that is materially inaccurate by reason of Subscriber's omission to
state facts about Subscriber that are called for by the Company in the
Subscriber Questionnaire.

         8.   Stock Option Matters.

         The Company shall, within thirty (30) days of the Closing Date, adopt
such amendments to the Company's stock option plans and the Company's By-laws
(the "Stock Option Plan and By-law Amendments") to provide that, unless approved
by the holders of a majority of the shares present and entitled to vote at a
duly convened meeting of shareholders, the Company shall not grant any stock
options with an exercise price that is less than 100% of the fair market value
of the underlying stock on the date of grant or reduce the exercise price of any
stock option granted under any existing or future stock option plan. This By-law
may not be amended or repealed without the affirmative vote of the holders of a
majority of the shares present and entitled to vote at a duly convened meeting
of shareholders. Upon the adoption of the Stock Option Plan and By-law
Amendments, the Company shall promptly furnish a copy of such amendments to the
Subscribers.

         9.   No Conflicts of Interest.

         The Company represents, warrants and covenants that, to the best of its
knowledge, no officer or employee of the State of Wisconsin Investment Board has
or will receive, directly or indirectly, a personal interest in the Company or
its property or anything of substantial economic value for his or her private
benefit from the Company, or anyone acting on its behalf, in connection with the
investment made pursuant to this Agreement.

         10.  Understandings.

         Subscriber understands, acknowledges and agrees with the Company and
the Placement Agent as follows:

                  10.1. Subscriber hereby acknowledges and agrees that upon
notice of acceptance from the Company and Placement Agent pursuant to Section
1.3, the Subscription hereunder is irrevocable by Subscriber, that, except as
required by law, Subscriber is not entitled to cancel, terminate or revoke this
Agreement or any agreements of Subscriber hereunder and that this Subscription
Agreement and such other agreements shall survive the death or disability of
Subscriber and shall be binding upon and inure to the benefit of the parties
hereto and their respective heirs, executors, administrators, successors, legal
representatives and permitted assigns. If Subscriber is more than one person,
the obligations of Subscriber hereunder shall be joint and several and the
agreements, representations, warranties and acknowledgments herein contained
shall be deemed to be made by and be binding upon each such person and his or
her heirs, executors, administrators, successors, legal representatives and
permitted assigns.

                  10.2. No federal or state agency has made any findings or
determination as to the fairness of the terms of this Offering for investment
nor any recommendations or endorsement of the Common Stock.

                  10.3. The Offering is intended to be exempt from registration
under the Act by virtue of Section 4(2) of the Act and the provisions of Rule
506 of Regulation D thereunder, which is in part dependent upon the truth,
completeness and accuracy of the statements made by Subscriber herein and in
Subscriber Questionnaire.

                  10.4. It is understood that in order not to jeopardize the
Offering's Offering's exempt status under Section 4(2) of the Act and Regulation
D, any transferee may, at a minimum, be required to fulfill the investor
suitability requirements thereunder.

                   10.5. The Placement Agent will receive compensation from the
Company in connection with the Offering but is not guaranteeing or assuming
responsibility for the operation or possible liability of the Company,
including, without limitation, compliance by the Company with the agreements
entered into in connection with the Offering, and the Placement Agent will not
supervise or participate in the operation or management of the Company. The
Company shall indemnify and hold harmless the Subscribers from and against all
fees, commissions or other payments owing by the Company to the Placement Agent
or any other person or firm acting on behalf of the Company hereunder.

                  10.6 8.6. No person or entity acting on behalf, or under the
authority, of Subscriber is or will be entitled to any broker's, finder's or
similar fee or commission in connection with this Subscription.

                   10.7. Subscriber acknowledges that the information furnished
in this Agreement by the Company or the Placement Agent to Subscriber or its
advisers in connection with the Offering, is confidential and nonpublic and
agrees that all such written information shall be kept in confidence by
Subscriber and neither used by Subscriber for Subscriber's Subscriber's personal
benefit (other than in connection with this Subscription), nor disclosed to any
third party for any reason; provided, however, that this obligation shall not
apply to any such information that (i) is part of the public knowledge or
literature and readily accessible at the date hereof, (ii) becomes a part of the
public knowledge or literature and readily accessible by publication (except as
a result of a breach of this provision) or (iii) is received from third parties
(except third parties who disclose such information in violation of any
confidentiality agreements or obligations, including, without limitation, any
subscription agreement entered into with the Company); and provided further that
the Company shall make public all confidential and nonpublic information
referred to in this Section 10.7 upon the earlier of the final Closing of this
Offering or November 30, 2000.

                  10.8. The representations, warranties and agreements of
Subscriber and the Company contained herein and in any other writing delivered
in connection with the Offering shall be true and correct in all material
respects on and as of the Closing Date of such Subscription as if made on and as
of the date the Company executes this Agreement and shall survive the execution
and delivery of this Agreement and the purchase of the Common Stock.

                   10.9. IN MAKING AN INVESTMENT DECISION, SUBSCRIBER MUST RELY
ON ITS OWN EXAMINATION OF THE COMPANY AND THE TERMS OF THE OFFERING, INCLUDING
THE MERITS AND RISKS INVOLVED. THE COMMON STOCK HAS NOT BEEN RECOMMENDED BY ANY
FEDERAL OR STATE SECURITIES COMMISSION OR REGULATORY AUTHORITY. ANY
REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

 11.     Miscellaneous.

                  11.1. Except as set forth elsewhere herein, any notice or
demand to be given or served in connection herewith shall be deemed to be
sufficiently given or served for all purposes by being sent as registered or
certified mail, return receipt requested, postage prepaid, in the case of the
Company, addressed to it at the address set forth below:

                                      NaPro BioTherapeutics, Inc.
                                      6304 Spine Road, Unit A
                                      Boulder, Colorado  80301
                                      Attention:  Kai Larson
                                      Vice President - General Counsel

and in the case of Subscriber to the address for correspondence set forth on the
Subscriber Questionnaire.

          11.2. This Agreement shall be enforced, governed and construed in all
respects in accordance with the laws of the State of Delaware, and shall be
binding upon Subscriber, Subscriber's heirs, estate, legal representatives,
successors and assigns and shall inure to the benefit of the Company, the
Placement Agent, and their respective successors and assigns. If any provision
of this Agreement is invalid or unenforceable under any applicable statute or
rule of law, then such provision shall be deemed inoperative to the extent that
it may conflict therewith and shall be deemed to be modified to conform with
such statute or rule of law. Any provision hereof that may prove invalid or
unenforceable under any law shall not affect the validity or enforceability of
any other provision hereof.

                   11.3. In any action, proceeding or counterclaim brought to
enforce any of the provisions of this Agreement or to recover damages, costs and
expenses in connection with any breach of the Agreement, the prevailing party
shall be entitled to be reimbursed by the opposing party for all of the
prevailing party's reasonable outside attorneys' fees, costs and other
out-of-pocket expenses incurred in connection with such action, proceeding or
counterclaim.

                   11.4. This Agreement (including Appendix I) and the
Subscriber Questionnaire constitutes the entire agreement among the parties
hereto with respect to the subject matter hereof. There are no restrictions,
promises, warranties or undertakings, other than those set forth herein. The
Company acknowledges that all material facts upon which it has relied in forming
its decision to enter into this Agreement are expressly set forth herein and
further acknowledges that the Subscriber has not made any representations,
express or implied, which are not set expressly set forth herein. This Agreement
supercedes all prior agreements and understandings among the parties hereto with
respect to the subject matter hereof.

                   11.5. The Company shall indemnify, defend and hold harmless
Subscriber and each of its agents, partners, members, officers, directors,
representatives, or affiliates (collectively, the "Subscriber Indemnities")
against any and all losses, liabilities, claims and expenses, including
reasonable attorneys' fees ("Losses"), sustained by Subscriber Indemnities
resulting from, arising out of, or connected with any material inaccuracy in,
breach of, or nonfulfillment of any representation, warranty, covenant or
agreement made by or other obligation of the Company contained in this Agreement
(including the Exhibits hereto) or in any document delivered in connection
herewith.

12.      Signature.  The  signature  page of this  Agreement is contained  as
part of the  applicable  Subscription Package, entitled "Signature Page."

                                   Appendix I

                               Registration Rights

         Definitions.

                  As used in this Appendix I, the following terms shall have the
meanings:

                           "Affiliate," of any specified Person means any other
                  Person who directly, or indirectly through one or more
                  intermediaries, is in control of, is controlled by, or is
                  under common control with, such specified Person. For purposes
                  of this definition, control of a Person means the power,
                  directly or indirectly, to direct or cause the direction of
                  the management and policies of such Person whether by
                  contract, securities, ownership or otherwise; and the terms
                  "controlling" and "controlled" have the respective meanings
                  correlative to the foregoing.

                           "Commission" means the Securities and Exchange
                  Commission.

                           "Exchange Act" means the Securities Exchange Act of
                  1934, as amended, and the rules and regulations of the
                  Commission thereunder, or any similar successor statute.

                           "Investors" means the Investors and any permitted
                  transferee or assignee of Registrable Securities who agrees to
                  become bound by all of the terms and provisions of this
                  Appendix I and the Subscription Agreements.

                           "Person" means any individual, partnership,
                  corporation, limited liability company, joint stock company,
                  association, trust, unincorporated organization, or a
                  government or agency or political subdivision thereof.

                           "Prospectus" means the prospectus (including any
                  preliminary prospectus and/or any final prospectus filed
                  pursuant to Rule 424(b) under the Securities Act and any
                  prospectus that discloses information previously omitted from
                  a prospectus filed as part of an effective registration
                  statement in reliance on Rule 430A under the Securities Act)
                  included in the Registration Statement, as amended or
                  supplemented by any prospectus supplement with respect to the
                  terms of the offering of any portion of the Registrable
                  Securities covered by the Registration Statement and by all
                  other amendments and supplements to such prospectus, including
                  all material incorporated by reference in such prospectus and
                  all documents filed after the date of such prospectus by the
                  Company under the Exchange Act and incorporated by reference
                  therein.

                           "Public Offering" means an offer registered with the
                  Commission and the appropriate state securities commissions by
                  the Company of its Common Stock and made pursuant to the
                  Securities Act.

                           "Registrable Securities" means the shares of Common
                  Stock purchased pursuant to the Subscription Agreements;
                  provided, however, a share of Common Stock shall cease to be a
                  Registrable Security for purposes of this Appendix I when it
                  no longer is a Restricted Security.

                           "Registration Statement" means a registration
                  statement of the Company filed on an appropriate form under
                  the Securities Act providing for the registration of, and the
                  sale on a continuous or delayed basis by the holders of, all
                  of the Registrable Securities pursuant to Rule 415 under the
                  Securities Act, including the Prospectus contained therein and
                  forming a part thereof, any amendments to such registration
                  statement and supplements to such Prospectus, and all exhibits
                  and other material incorporated by reference in such
                  registration statement and Prospectus.

                           "Restricted Security" means any share of Common Stock
                  except any that (i) have been registered pursuant to an
                  effective registration statement under the Securities Act and
                  sold in a manner contemplated by the prospectus included in
                  such registration statement, (ii) have been transferred in
                  compliance with the resale provisions of Rule 144 under the
                  Securities Act (or any successor provision thereto) or is
                  transferable pursuant to paragraph (k) of Rule 144 under the
                  Securities Act (or any successor provision thereto), or (iii)
                  otherwise has been transferred and a new share of Common Stock
                  not subject to transfer restrictions under the Securities Act
                  has been delivered by or on behalf of the Company.

                           "Securities Act" means the Securities Act of 1933, as
                  amended, and the rules and regulations of the Commission
                  thereunder, or any similar successor statute.

                  All capitalized terms used and not defined herein have the
respective meaning assigned to them in the Subscription Agreements.

         Registration.

                  Filing and Effectiveness of Registration Statement. The
Company shall prepare and file with the Commission not later than fifteen days
following the final Closing (as that term is defined in the accompanying
Subscription Agreement) (the "Filing Deadline") a Registration Statement
relating to the offer and sale of the Registrable Securities and shall use its
best efforts to cause the Commission to declare such Registration Statement
effective under the Securities Act as promptly as practicable but not later than
60 days after final Closing. The shares of Common Stock and the shares of Common
Stock underlying warrants issued to Stonegate Securities, Inc. shall be included
in the Registration Statement. The Company shall notify the Investors by written
notice that such Registration Statement has been declared effective by the
Commission within three (3) business days of such declaration by the Commission.

                  Registration Default. If the Registration Statement covering
the Registrable Securities required to be filed by the Company pursuant to
Section 2(a) is not (i) filed with the Commission not later than the Filing
Deadline or (ii) declared effective by the Commission not later than the earlier
of 90 days after the Initial Closing Date (as defined in the Subscription
Agreement) or 60 days after filing of the Registration Statement (either of
which, without duplication, an "Initial Date"), then the Company shall make the
payments to the Investors as provided in the next sentence as liquidated damages
and not as a penalty. The amount to be paid by the Company to the Investors
shall be determined as of each Computation Date (as defined below), and such
amount shall be equal to 2.5% (the "Liquidated Damage Rate") of the Purchase
Price (as defined in the Subscription Agreements) from the Initial Date to the
first Computation Date and for each Computation Date thereafter, calculated on a
pro rata basis to the date on which the Registration Statement is filed with (in
the event of an Initial Date pursuant to clause (i) above) or declared effective
by (in the event of an Initial Date pursuant to clause (ii) above) the
Commission (the "Periodic Amount") provided, however, that in no event shall the
liquidated damages be less than $25,000. The full Periodic Amount shall be paid
by the Company to the Investors, pro rata, by wire transfer of immediately
available funds within three days after each Computation Date.

                  As used in this Section 2(b), "Computation Date" means the
date which is 30 days after the Initial Date and, if the Registration Statement
required to be filed by the Company pursuant to Section 2(a) has not theretofore
been declared effective by the Commission, each date which is 30 days after the
previous Computation Date until such Registration Statement is so declared
effective.

                  Notwithstanding the above, if the Registration Statement
covering the Registrable Securities required to be filed by the Company pursuant
to Section 2(a) hereof is not filed with the Commission by the Filing Deadline,
the Company shall be in default of the terms of this Appendix I, and the
Investors shall be entitled to damages as set forth above and any other damages
permitted by law.

                  Piggyback Registration Rights. (i)If the Company proposes to
register any of its Common Stock or any other shares of common stock of the
Company under the Securities Act (other than a registration (A) on Form S-8 or
S-4 or any successor or similar forms, (B) relating to Common Stock or any other
shares of common stock of the Company issuable upon exercise of employee share
options or in connection with any employee benefit or similar plan of the
Company or (C) in connection with a direct or indirect acquisition by the
Company of another Person or any transaction with respect to which Rule 145 (or
any successor provision) under the Securities Act applies), whether or not for
sale for its own account, it will each such time, give prompt written notice at
least 20 days prior to the anticipated filing date of the registration statement
relating to such registration to the Investors, which notice shall set forth
such Investors' rights under this Section 2(c) and shall offer the Investors the
opportunity to include in such registration statement such number of Registrable
Securities as the Investors may request. Upon the written request of an Investor
made within 10 days after the receipt of notice from the Company (which request
shall specify the number of Registrable Securities intended to be disposed of by
such Investors), the Company will use its best efforts to effect the
registration under the Securities Act of all Registrable Securities that the
Company has been so requested to register by the Investors, to the extent
requisite to permit the disposition of the Registrable Securities to be so
registered; provided, however, that (A) if such registration involves a Public
Offering, the Investors must sell their Registrable Securities to the
underwriters on the same terms and conditions as apply to the Company and (B)
if, at any time after giving written notice of its intention to register any
Registrable Securities pursuant to this Section 2(c) and prior to the effective
date of the registration statement filed in connection with such registration,
the Company shall determine for any reason not to register such Registrable
Securities, the Company shall give written notice to the Investors and,
thereupon, shall be relieved of its obligation to register any Registrable
Securities in connection with such registration. The Company's obligations under
this Section 2(c) shall terminate on the date that the registration statement to
be filed in accordance with Section 2(a) is declared effective by the
Commission. (ii) If a registration pursuant to this Section 2(c) involves a
Public Offering and the managing underwriter thereof advises the Company that,
in its view, the number of shares of Common Stock, if any, or other shares of
Common Stock that the Company and the Investors intend to include in such
registration exceeds the largest number of shares of Common Stock (including any
other shares of Common Stock or warrants of the Company) that can be sold
without having an adverse effect on such Public Offering (the "Maximum Offering
Size"), the Company will include in such registration only that number of shares
of Common Stock which does not exceed the Maximum Offering Size, in the
following order of priorities: (1) first, all securities the Company proposes to
sell for its own account, (2) second, up to the full number of securities
proposed to be registered for the account of the holders of securities entitled
to inclusion of their securities in the Registration Statement by reason of
demand registration rights, and (3) third, the securities requested to be
registered by other holders of securities entitled to participate in the
registration, drawn from them pro-rata based on the number of shares each has
requested to be included in such registration and the Investors pursuant to this
Appendix I.

                  If as a result of the proration provisions of this Section
2(c)(ii), the Investors are not entitled to include all such Registrable
Securities in such registration, such Investors may elect to withdraw their
request to include any Registrable Securities in such registration.

                  Notwithstanding the foregoing, the Company shall have no
obligations under this Section 2(c) hereof at any time that such Registrable
Securities are the subject of an effective registration statement.

         Obligations of the Company. In connection with the registration of the
Registrable Securities, the Company shall use its reasonable best efforts to:

                  Subject to the provisions of Section 3(r) hereof, promptly (i)
prepare and file with the Commission such amendments (including post-effective
amendments) to the Registration Statement and supplements to the Prospectus as
may be necessary to keep the Registration Statement continuously effective and
in compliance with the provisions of the Securities Act applicable thereto so as
to permit the Prospectus forming part thereof to be current and useable by
Investors for resales of the Registrable Securities for a period of two years
from the date the Registrable Securities is first declared effective by the
Commission (the "Effective Time") or such shorter period that will terminate
when all the Registrable Securities covered by the Registration Statement have
been sold pursuant thereto in accordance with the plan of distribution provided
in the Prospectus, transferred pursuant to Rule 144 under the Securities Act or
otherwise transferred in a manner that results in the delivery of new securities
not subject to transfer restrictions under the Securities Act (the "Registration
Period") and (ii) take all lawful action such that each of (A) the Registration
Statement and any amendment thereto does not, when it becomes effective, contain
an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make the statements therein, not misleading
and (B) the Prospectus forming part of the Registration Statement, and any
amendment or supplement thereto, does not at any time during the Registration
Period include an untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not
misleading. Notwithstanding the foregoing, the Company's obligations hereunder
shall terminate as to any investor at such time as that Investor's Registrable
Securities can be sold under Rule 144(k);

                  During the Registration Period, comply with the provisions of
the Securities Act with respect to the Registrable Securities of the Company
covered by the Registration Statement until such time as all of such Registrable
Securities have been disposed of in accordance with the intended methods of
disposition by the Investors as set forth in the Prospectus forming part of the
Registration Statement;

                  (i) Prior to the filing with the Commission of any
Registration Statement (including any amendments thereto) and the distribution
or delivery of any Prospectus (including any supplements thereto), provide draft
copies thereof (including a copy of the accountant's consent letter to be
included in the filing) to Stonegate Securities, Inc. ("Stonegate") and reflect
in such documents all such comments as Stonegate reasonably may propose; and
(ii) furnish to Stonegate for delivery to each Investor whose Registrable
Securities are included in the Registration Statement, (A) promptly after the
same is prepared and publicly distributed, filed with the Commission, or
received by the Company, one copy of the Registration Statement, each
Prospectus, and each amendment or supplement thereto, and (B) such number of
copies of the Prospectus and all amendments and supplements thereto and such
other documents, as such Investor may reasonably request in order to facilitate
the disposition of the Registrable Securities owned by such Investor;

                  (i) Register or qualify the Registrable Securities covered by
the Registration Statement under such securities or "blue sky" laws of all
jurisdictions requiring blue sky registration or qualification, (ii) prepare and
file in such jurisdictions such amendments (including post-effective amendments)
and supplements to such registrations and qualifications as may be necessary to
maintain the effectiveness thereof at all times during the Registration Period,
(iii) take all such other lawful actions as may be necessary to maintain such
registrations and qualifications in effect at all times during the Registration
Period, and (iv) take all such other lawful actions reasonably necessary or
advisable to qualify the Registrable Securities for sale in such jurisdictions;
provided, however, that the Company shall not be required in connection
therewith or as a condition thereto to (A) qualify to do business in any
jurisdiction where it would not otherwise be required to qualify but for this
Section 3(d), (B) subject itself to general taxation in any such jurisdiction or
(C) file a general consent to service of process in any such jurisdiction;

                  As promptly as practicable after becoming aware of such event,
notify each Investor of the occurrence of any event, as a result of which the
Prospectus included in the Registration Statement, as then in effect, includes
an untrue statement of a material fact or omits to state a material fact
required to be stated therein or necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading, and
promptly prepare an amendment to the Registration Statement and supplement to
the Prospectus to correct such untrue statement or omission, and deliver a
number of copies of such supplement and amendment to each Investor as such
Investor may reasonably request;

                  As promptly as practicable after becoming aware of such event,
notify each Investor who holds Registrable Securities being sold (or, in the
event of an underwritten offering, the managing underwriters) of the issuance by
the Commission of any stop order or other suspension of the effectiveness of the
Registration Statement at the earliest possible time and take all lawful action
to effect the withdrawal, recession or removal of such stop order or other
suspension;

                  Cause all the Registrable Securities covered by the
Registration Statement to be listed on the principal national securities
exchange, and included in an inter-dealer quotation system of a registered
national securities association, on or in which securities of the same class or
series issued by the Company are then listed or included;

                  Maintain a transfer agent and registrar, which may be a single
entity, for the Registrable Securities not later than the effective date of the
Registration Statement;

                  Cooperate with the Investors who hold Registrable Securities
being offered to facilitate the timely preparation and delivery of certificates
for the Registrable Securities to be offered pursuant to the registration
statement and enable such certificates for the Registrable Securities to be in
such denominations or amounts, as the case may be, as the Investors reasonably
may request and registered in such names as the Investor may request; and,
within three business days after a registration statement which includes
Registrable Securities is declared effective by the Commission, deliver and
cause legal counsel selected by the Company to deliver to the transfer agent for
the Registrable Securities (with copies to the Investors whose Registrable
Securities are included in such registration statement) an appropriate
instruction and, to the extent necessary, an opinion of such counsel;

                  Take all such other lawful actions reasonably necessary to
expedite and facilitate the disposition by the Investors of their Registrable
Securities in accordance with the intended methods therefor provided in the
Prospectus which are customary under the circumstances;

                  Make generally available to its security holders as soon as
practicable, but in any event not later than three (3) months after (i) the
effective date (as defined in Rule 158(c) under the Securities Act) of the
Registration Statement, and (ii) the effective date of each post-effective
amendment to the Registration Statement, as the case may be, an earnings
statement of the Company and its subsidiaries complying with Section 11(a) of
the Securities Act and the rules and regulations of the Commission thereunder
(including, at the option of the Company, Rule 158);

                  In the event of an underwritten offering, promptly include or
incorporate in a Prospectus supplement or post-effective amendment to the
Registration Statement such information as the managers reasonably agree should
be included therein and to which the Company does not reasonably object and make
all required filings of such Prospectus supplement or post-effective amendment
as soon as practicable after it is notified of the matters to be included or
incorporated in such Prospectus supplement or post-effective amendment;

                  In connection with any underwritten offering, make such
representations and warranties to the Investors participating in such
underwritten offering and to the managers, in form, substance and scope as are
customarily made by the Company to underwriters in secondary underwritten
offerings;

                  In connection with any underwritten offering, obtain opinions
of counsel to the Company (which counsel and opinions (in form, scope and
substance) shall be reasonably satisfactory to the managers) addressed to the
underwriters, covering such matters as are customarily covered in opinions
requested in secondary underwritten offerings (it being agreed that the matters
to be covered by such opinions shall include, without limitation, as of the date
of the opinion and as of the date the Registration Statement is first declared
effective or most recent post- effective amendment thereto, as the case may be,
the absence from the Registration Statement and the Prospectus, including any
documents incorporated by reference therein, of an untrue statement of a
material fact or the omission of a material fact required to be stated therein
or necessary to make the statements therein (in the case of the Prospectus, in
light of the circumstances under which they were made) not misleading, subject
to customary limitations);

                  In connection with any underwritten offering, obtain "cold
comfort" letters and updates thereof from the independent public accountants of
the Company (and, if necessary, from the independent public accountants of any
subsidiary of the Company or of any business acquired by the Company, in each
case for which financial statements and financial data are, or are required to
be, included in the Registration Statement), addressed to each underwriter
participating in such underwritten offering (if such underwriter has provided
such letter, representations or documentation, if any, required for such cold
comfort letter to be so addressed), in customary form and covering matters of
the type customarily covered in "cold comfort" letters in connection with
secondary underwritten offerings;

                  In connection with any underwritten offering, deliver such
documents and certificates as may be reasonably required by the managers, if
any; and

                  In the event that any broker-dealer registered under the
Exchange Act shall be an "Affiliate" (as defined in Rule 2729(b)(1) of the rules
and regulations of the National Association of Securities Dealers, Inc. (the
"NASD Rules") (or any successor provision thereto)) of the Company or has a
"conflict of interest" (as defined in Rule 2720(b)(7) of the NASD Rules (or any
successor provision thereto)) and such broker-dealer shall underwrite,
participate as a member of an underwriting syndicate or selling group or assist
in the distribution of any Registrable Securities covered by the Registration
Statement, whether as a holder of such Registrable Securities or as an
underwriter, a placement or sales agent or a broker or dealer in respect
thereof, or otherwise, the Company shall assist such broker-dealer in complying
with the requirements of the NASD Rules, including, without limitation, by (A)
engaging a "qualified independent underwriter" (as defined in Rule 2720(b)(15)
of the NASD Rules (or any successor provision thereto)) to participate in the
preparation of the Registration Statement relating to such Registrable
Securities, to exercise usual standards of due diligence in respect thereof and
to recommend the public offering price of such Registrable Securities, (B)
indemnifying such qualified independent underwriter to the extent of the
indemnification of underwriters provided in Section 5 hereof, and (C) providing
such information to such broker-dealer as may be required in order for such
broker-dealer to comply with the requirements of the NASD Rules.

                  Notwithstanding anything to the contrary in Section 3, at any
time after the Registration Statement has been declared effective, the Company
may delay the disclosure of material non-public information concerning the
Company the disclosure of which at the time is not, in the good faith opinion of
the Company and its counsel, in the best interest of the Company (a "Grace
Period"); provided, that the Company shall promptly (i) notify the Investors in
writing of the existence of material non-public information giving rise to a
Grace Period and the date on which the Grace Period will begin, and (ii) notify
the Investors in writing of the date on which the Grace Period ends; and,
provided further, that during any consecutive 365 day period, there shall be
only two Grace Periods, such Grace Periods in total not to exceed 30 days. For
purposes of determining the length of a Grace Period above, the Grace Period
shall begin on and include the date the holders receive the notice referred to
in clause (i) and shall end on and include the date the holders receive the
notice referred to in clause (ii).

                  Notwithstanding the foregoing, the Company shall have no
obligations under Section 3(l) through (q) unless it is effecting an
underwritten offering pursuant to Section 2(c).

         Obligations of the Investors. In connection with the registration of
the Registrable Securities, the Investors shall have the following obligations:

                  It shall be a condition precedent to the obligations of the
Company to complete the registration pursuant to this Appendix I with respect to
the Registrable Securities of a particular Investor that such Investor shall
furnish to the Company such information regarding itself, the Registrable
Securities held by it and the intended method of disposition of the Registrable
Securities held by it as shall be reasonably required to effect the registration
of such Registrable Securities and shall execute such documents in connection
with such registration as the Company may reasonably request. As least ten
business days prior to the first anticipated filing date of the Registration
Statement, the Company shall notify each Investor and its counsel, whether
in-house or otherwise identified on Schedule 4(a) ("Counsel") of the information
the Company requires from each such Investor (the "Requested Information") if
such Investor elects to have any of its Registrable Securities included in the
Registration Statement. If at least four business days prior to the anticipated
filing date the Company has not received the Requested Information from an
Investor (a "Non-Responsive Investor") or its Counsel, then the Company shall
send such Non-Responsive Investor and its Counsel a reminder of such information
request. If at least two business days prior to the anticipated filing date the
Company still has not received the Requested Information from such
Non-Responsive Investor or its Counsel, then the Company may file the
Registration Statement without including Registrable Securities of such
Non-Responsive Investor and have no further registration obligations to the
Non-Responsive Investor;

                  Each Investor by its acceptance of the Registrable Securities
agrees to cooperate with the Company in connection with the preparation and
filing of the Registration Statement hereunder, unless such Investor has
notified the Company in writing of its election to exclude all of its
Registrable Securities from the Registration Statement; the Company shall, on
its part, ensure that Item 507 of Regulation S-K of the Securities Act
(regarding information on the selling security holders) be complied with in
connection with its preparation and filing of the Registration Statement
hereunder;

                  As promptly as practicable after becoming aware of such event,
notify the Company of the occurrence of any event, as a result of which the
Prospectus included in the Registration Statement, as then in effect, includes
an untrue statement of a material fact or omits to state a material fact
required to be stated therein or necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading; and

                  Each Investor agrees that, upon receipt of any notice from the
Company of the occurrence of any event of the kind described in Section 3(e) or
3(f), it shall immediately discontinue its disposition of Registrable Securities
pursuant to the Registration Statement covering such Registrable Securities
until such Investor's receipt of the copies of the supplemented or amended
Prospectus contemplated by Section 3(e) and, if so directed by the Company, such
Investor shall deliver to the Company (at the expense of the Company) or destroy
(and deliver to the Company a certificate of destruction) all copies in such
Investor's possession, of the Prospectus covering such Registrable Securities
current at the time of receipt of such notice.

         Expenses of Registration. All expenses, other than underwriting
discounts and commissions, incurred in connection with registrations, filings or
qualifications pursuant to Section 3, but including, without limitation, all
registration, listing, and qualifications fees, printing and engraving fees,
accounting fees, and the fees and disbursements of counsel for the Company, and
the reasonable fees, not to exceed $5,000.00, of one firm of counsel to the
holders of a majority in interest of the Registrable Securities shall be borne
by the Company.

         Indemnification and Contribution.

                  The Company shall indemnify and hold harmless each Investor
and each underwriter, if any, which facilitates the disposition of Registrable
Securities, and each of their respective officers and directors and each person
who controls such Investor or underwriter within the meaning of Section 15 of
the Securities Act or Section 20 of the Exchange Act (each such person being
sometimes hereinafter referred to as an "Indemnified Person") from and against
any losses, claims, damages or liabilities, joint or several, to which such
Indemnified Person may become subject under the Securities Act or otherwise,
insofar as such losses, claims, damages or liabilities (or actions in respect
thereof) arise out of or are based upon an untrue statement or alleged untrue
statement of a material fact contained in any Registration Statement or an
omission or alleged omission to state therein a material fact required to be
stated therein or necessary to make the statements therein, not misleading, or
arise out of or are based upon an untrue statement or alleged untrue statement
of a material fact contained in any Prospectus or an omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein, in the light of the circumstances
under which they were made, not misleading; and the Company hereby agrees to
reimburse such Indemnified Person for all reasonable legal and other expenses
incurred by them in connection with investigating or defending any such action
or claim as and when such expenses are incurred; provided, however, that the
Company shall not be liable to any such Indemnified Person in any such case to
the extent that any such loss, claim, damage or liability arises out of or is
based upon (i) an untrue statement or alleged untrue statement made in, or an
omission or alleged omission from, such Registration Statement or Prospectus in
reliance upon and in conformity with written information furnished to the
Company by such Indemnified Person expressly for use therein or (ii) in the case
of the occurrence of an event of the type specified in Section 3(e), the use by
the Indemnified Person of an outdated or defective Prospectus after the Company
has provided to such Indemnified Person written notice that such Prospectus is
outdated or defective.

                  Indemnification by the Investors and Underwriters. Each
Investor agrees, as a consequence of the inclusion of any of its Registrable
Securities in a Registration Statement, and each underwriter, if any, which
facilitates the disposition of Registrable Securities shall agree, as a
consequence of facilitating such disposition of Registrable Securities,
severally and not jointly, to (i) indemnify and hold harmless the Company, its
directors (including any person who, with his or her consent, is named in the
Registration Statement as a director nominee of the Company), its officers and
each person, if any, who controls the Company within the meaning of either
Section 15 of the Securities Act or Section 20 of the Exchange Act, against any
losses, claims, damages or liabilities to which the Company or such other
persons may become subject, under the Securities Act or otherwise, insofar as
such losses, claims, damages or liabilities (or actions in respect thereof)
arise out of or are based upon an untrue statement or alleged untrue statement
of a material fact contained in such Registration Statement or Prospectus or
arise out of or are based upon the omission or alleged omission to state therein
a material fact required to be stated therein or necessary to make the
statements therein (in light of the circumstances under which they were made, in
the case of the Prospectus), not misleading, in each case to the extent, but
only to the extent, that such untrue statement or alleged untrue statement or
omission or alleged omission was made in reliance upon and in conformity with
written information furnished to the Company by such holder or underwriter
expressly for use therein; provided, however, that no Investor or underwriter
shall be liable under this Section 6(b) for any amount in excess of the gross
proceeds paid to such Investor or underwriter in respect of shares sold by it,
and (ii) reimburse the Company for any legal or other expenses incurred by the
Company in connection with investigating or defending any such action or claim
as such expenses are incurred.

                  Notice of Claims, etc. Promptly after receipt by a party
seeking indemnification pursuant to this Section 6 (an "Indemnified Party") of
written notice of any investigation, claim, proceeding or other action in
respect of which indemnification is being sought (each, a "Claim"), the
Indemnified Party promptly shall notify the party against whom indemnification
pursuant to this Section 6 is being sought (the "Indemnifying Party") of the
commencement thereof; but the omission to so notify the Indemnifying Party shall
not relieve it from any liability that it otherwise may have to the Indemnified
Party, except to the extent that the Indemnifying Party is materially prejudiced
and forfeits substantive rights and defenses by reason of such failure. In
connection with any Claim as to which both the Indemnifying Party and the
Indemnified Party are parties, the Indemnifying Party shall be entitled to
assume the defense thereof. Notwithstanding the assumption of the defense of any
Claim by the Indemnifying Party, the Indemnified Party shall have the right to
employ separate legal counsel and to participate in the defense of such Claim,
and the Indemnifying Party shall bear the reasonable fees, out-of-pocket costs
and expenses of such separate legal counsel to the Indemnified Party if (and
only if): (x) the Indemnifying Party shall have agreed to pay such fees, costs
and expenses, (y) the Indemnified Party and the Indemnifying Party shall
reasonably have concluded that representation of the Indemnified Party by the
Indemnifying Party by the same legal counsel would not be appropriate due to
actual or, as reasonably determined by legal counsel to the Indemnified Party,
potentially differing interests between such parties in the conduct of the
defense of such Claim, or if there may be legal defenses available to the
Indemnified Party that are in addition to or disparate from those available to
the Indemnifying Party, or (z) the Indemnifying Party shall have failed to
employ legal counsel reasonably satisfactory to the Indemnified Party within a
reasonable period of time after notice of the commencement of such Claim. If the
Indemnified Party employs separate legal counsel in circumstances other than as
described in clauses (x), (y) or (z) above, the fees, costs and expenses of such
legal counsel shall be borne exclusively by the Indemnified Party. Except as
provided above, the Indemnifying Party shall not, in connection with any Claim
in the same jurisdiction, be liable for the fees and expenses of more than one
firm of counsel for the Indemnified Party (together with appropriate local
counsel). The Indemnified Party shall not, without the prior written consent of
the Indemnifying Party (which consent shall not unreasonably be withheld),
settle or compromise any Claim or consent to the entry of any judgment that does
not include an unconditional release of the Indemnifying Party from all
liabilities with respect to such Claim or judgment.

                  Contribution. If the indemnification provided for in this
Section 6 is unavailable to or insufficient to hold harmless an Indemnified
Person under subsection (a) or (b) above in respect of any losses, claims,
damages or liabilities (or actions in respect thereof) referred to therein, then
each Indemnifying Party shall contribute to the amount paid or payable by such
Indemnified Party as a result of such losses, claims, damages or liabilities (or
actions in respect thereof) in such proportion as is appropriate to reflect the
relative fault of the Indemnifying Party and the Indemnified Party in connection
with the statements or omissions which resulted in such losses, claims, damages
or liabilities (or actions in respect thereof), as well as any other relevant
equitable considerations. The relative fault of such Indemnifying Party and
Indemnified Party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or omission or
alleged omission to state a material fact relates to information supplied by
such Indemnifying Party or by such Indemnified Party, and the parties' relative
intent, knowledge, access to information and opportunity to correct or prevent
such statement or omission. The parties hereto agree that it would not be just
and equitable if contribution pursuant to this Section 6(d) were determined by
pro rata allocation (even if the Investors or any underwriters were treated as
one entity for such purpose) or by any other method of allocation which does not
take account of the equitable considerations referred to in this Section 6(d).
The amount paid or payable by an Indemnified Party as a result of the losses,
claims, damages or liabilities (or actions in respect thereof) referred to above
shall be deemed to include any legal or other fees or expenses reasonably
incurred by such Indemnified Party in connection with investigating or defending
any such action or claim. No person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation. The obligations of the Investors and any underwriters in this
Section 6(d) to contribute shall be several in proportion to the percentage of
Registrable Securities registered or underwritten, as the case may be, by them
and not joint.

                  Notwithstanding any other provision of this Section 6, in no
event shall any (i) Investor be required to undertake liability to any person
under this Section 6 for any amounts in excess of the dollar amount of the gross
proceeds to be received by such Investor from the sale of such Investor's
Registrable Securities pursuant to any Registration Statement under which such
Registrable Securities are to be registered under the Securities Act.

                  The obligations of the Company under this Section 6 shall be
in addition to any liability which the Company may otherwise have to any
Indemnified Person and the obligations of any Indemnified Person under this
Section 6 shall be in addition to any liability which such Indemnified Person
may otherwise have to the Company. The remedies provided in this Section 6 are
not exclusive and shall not limit any rights or remedies which may otherwise be
available to an indemnified party at law or in equity.

         Rule 144. With a view to making available to the Investors the benefits
of Rule 144 under the Securities Act or any other similar rule or regulation of
the Commission that may at any time permit the Investors to sell securities of
the Company to the public without registration ("Rule 144"), the Company agrees
to:

                  comply with the provisions of paragraph (c) (1) of Rule 144;
and

                  file with the Commission in a timely manner all reports and
other documents required to be filed by the Company pursuant to Section 13 or
15(d) under the Exchange Act; and, if at any time it is not required to file
such reports but in the past had been required to or did file such reports, it
will, upon the request of any Investor, make available other information as
required by, and so long as necessary to permit sales of, its Registrable
Securities pursuant to Rule 144.

         Assignment. The rights to have the Company register Registrable
Securities pursuant to this Appendix I may be assigned or transferred only with
the prior written consent of the Company, and any such assignment or transfer
without such consent shall be void and of no effect. In the event of any such
permitted assignment or transfer by the Investors to any permitted transferee of
all or any portion of such Registrable Securities such transfer will be allowed
only if: (a) the Investor agrees in writing with the transferee or assignee to
assign such rights, and a copy of such agreement is furnished to the Company
within a reasonable time after such assignment, (b) the Company is, within a
reasonable time after such transfer or assignment, furnished with written notice
of (i) the name and address of such transferee or assignee and (ii) the
securities with respect to which such registration rights are being transferred
or assigned, (c) immediately following such transfer or assignment, the
securities so transferred or assigned to the transferee or assignee constitute
Restricted Securities, and (d) at or before the time the Company received the
written notice contemplated by clause (b) of this sentence the transferee or
assignee agrees in writing with the Company to be bound by all of the provisions
contained herein.

         Amendment and Waiver. Any provision of this Appendix I may be amended
and the observance thereof may be waived (either generally or in a particular
instance and either retroactively or prospectively), only with the written
consent of the Company and Investors who hold a 66 2/3% interest of the
Registrable Securities. Any amendment or waiver effected in accordance with this
Section 9 shall be binding upon each Investor and the Company.

         Miscellaneous.

                  A person or entity shall be deemed to be a holder of
Registrable Securities whenever such person or entity owns of record such
Registrable Securities. If the Company receives conflicting instructions,
notices or elections from two or more persons or entities with respect to the
same Registrable Securities, the Company shall act upon the basis of
instructions, notice or election received from the registered owner of such
Registrable Securities.

                  If after the date hereof and prior to the Commission declaring
the Registration Statement to be filed pursuant to Section 2(a) effective under
the Securities Act, the Company grants to any Person any registration rights
with respect to any Company securities which are more favorable to such other
Person than those provided in this Appendix I, then the Company forthwith shall
grant (by means of an amendment to this Appendix I or otherwise) identical
registration rights to all Investors hereunder.

                  Except as may be otherwise provided herein, any notice or
other communication or delivery required or permitted hereunder shall be in
writing and shall be delivered personally or sent by certified mail, postage
prepaid, or by a nationally recognized overnight courier service as follows, and
shall be deemed given when actually received.

                           if to the Company, to:

                           NaPro BioTherapeutics, Inc.
                           6304 Spine Road, Unit A
                           Boulder, Colorado  80301
                           Attention:  Kai Larson
                            Vice President - General Counsel

                           if to the Investors, to:

                           Each individual or entity identified on Schedule
                           10(c) attached hereto

                           With a copy to:

                           -------------------
                           Phone: ___________________
                           Fax: (___________________
                           Attention: ___________________

                  The Company or any Investor may change the foregoing address
by notice given pursuant to this Section 10(c).

                  Failure of any party to exercise any right or remedy under
this Appendix I or otherwise, or delay by a party in exercising such right or
remedy, shall not operate as a waiver thereof.

                  This Appendix I shall be governed by and interpreted in
accordance with the laws of the State of Delaware. Each of the parties consents
to the jurisdiction of the federal courts whose districts encompass the City of
Boulder or the state courts of the State of Colorado sitting in Boulder,
Colorado in connection with any dispute arising under this Appendix I and hereby
waives, to the maximum extent permitted by law, any objection including any
objection based on forum non conveniens, to the bringing of any such proceeding
in such jurisdictions.

                  The remedies provided in this Appendix I are cumulative and
not exclusive of any remedies provided by law. If any term, provision, covenant
or restriction of this Appendix I is held by a court of competent jurisdiction
to be invalid, illegal, void or unenforceable, the remainder of the terms,
provisions, covenants and restrictions set forth herein shall remain in full
force and effect and shall in no way be affected, impaired or invalidated, and
the parties hereto shall use their best efforts to find and employ an
alternative means to achieve the same or substantially the same result as that
contemplated by such term, provision, covenant or restriction. It is hereby
stipulated and declared to be the intention of the parties that they would have
executed the remaining terms, provisions, covenants and restrictions without
including any of such that may be hereafter declared invalid, illegal, void or
unenforceable.

                  The Company shall not enter into any agreement with respect to
its securities that is inconsistent with the rights granted to the holders of
Registrable Securities in this Appendix I or otherwise conflicts with the
provisions hereof. The Company is not currently a party to any agreement
granting any registration rights with respect to any of its securities to any
person which conflicts with the Company's obligations hereunder or gives any
other party the right to include any securities in any Registration Statement
filed pursuant hereto, except for such rights and conflicts as have been
irrevocably waived. Without limiting the generality of the foregoing, without
the written consent of the holders of a 66 2/3% interest of the Registrable
Securities, the Company shall not grant to any person the right to request it to
register any of its securities under the Securities Act unless the rights so
granted are pari pasu to the prior rights of the holders of Registrable
Securities set forth herein, and are not otherwise in conflict or inconsistent
with the provisions of this Appendix I. The restrictions on the Company's rights
to grant registration rights under this paragraph shall terminate on the date
all Registerable Securities have been registered pursuant to a Registration
Statement that has been declared effective by the Commission. Notwithstanding
the foregoing, Subscriber acknowledges that the Company has obligations to
register shares pursuant to that certain Stock Purchase Agreement dated July 23,
1999 between NaPro and Abbott Laboratories, and the Company's fulfillment of
such obligations shall not cause the Company to be in default hereunder.

                  This Appendix I and the Subscription Agreements constitute the
entire agreement among the parties hereto with respect to the subject matter
hereof. There are no restrictions, promises, warranties or undertakings, other
than those set forth or referred to herein. This Appendix I and the Subscription
Agreements supersede all prior agreements and undertakings among the parties
hereto with respect to the subject matter hereof.

                  Subject to the requirements of Section 8 hereof, this Appendix
I shall inure to the benefit of and be binding upon the successors and assigns
of each of the parties hereto.

                  All pronouns and any variations thereof refer to the
masculine, feminine or neuter, singular or plural, as the context may require.

                  The headings in this Appendix I are for convenience of
reference only and shall not limit or otherwise affect the meaning thereof.

The Company acknowledges that any failure by the Company to perform its
obligations under Section 3, or any delay in such performance could result in
damages to the Investors and the Company agrees that, in addition to any other
liability the Company may have by reason of any such failure or delay, the
Company may be liable for all damages caused by such failure or delay.

SCHEDULE OF OMITTED PORTIONS OF DOCUMENTS

The above Form of Subscription Agreement including Registration Rights differs
from the individually executed Subscription Agreements. Signature pages were
omitted which includes information concerning the identity of the individual
subscribers as well as information regarding the number of shares purchased by
each of the individual subscribers.

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