Document:

EX-10.22

 Exhibit 10.22 

THIS NOTE AND THE SECURITIES ISSUABLE UPON THE CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR UNDER THE SECURITIES LAWS OF ANY STATES IN THE UNITED STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND
THE APPLICABLE STATE SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR
RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 
 CONVERTIBLE PROMISSORY NOTE 

 

			
	Note Series:	 	     2017A

	Date of Note:	 	  

	Principal Amount of Note:	 	     $

 For value received PERSONALIS, INC., a Delaware corporation (the
“Company”) promises to pay to the undersigned holder or such party’s assigns (the “Holder”) the principal amount set forth above with simple interest on the outstanding principal amount at the
rate of 8% per annum. Interest shall commence with the date hereof and shall continue on the outstanding principal until paid in full or converted. Interest shall be computed on the basis of a year of 365 days for the actual number of days
elapsed. All unpaid interest and principal shall be due and payable upon request of the Requisite Holders on or after June 28, 2018 or such later date as may be determined by the Requisite Holders (the “Maturity Date”).

  

	 	1.	 BASIC TERMS. 

(a)    Series of Notes. This convertible promissory note (the “Note”) is
issued as part of a series of notes designated by the Note Series above (collectively, the “Notes”) and issued in a series of multiple closings to certain persons and entities (collectively, the
“Holders”). The Company shall maintain a ledger of all Holders. 

(b)    Payments. All payments of interest and principal shall be in lawful money of the United States of
America and shall be made pro rata among all Holders. All payments shall be applied first to accrued interest, and thereafter to principal. 

(c)    Prepayment. The Company may not prepay this Note prior to the Maturity Date without the consent of
Lightspeed Venture Partners VIII, L.P. and Abingworth Bioventures V, LP (the “Requisite Holders”). 
  

	 	2.	 CONVERSION AND REPAYMENT. 

(a)    Conversion upon a Qualified Financing. In the event that the Company issues and sells shares of its
equity securities (the “Equity Securities”) to investors (the “Investors”) on or before the Maturity Date in an equity financing with total proceeds to the Company of not less than $10,000,000
(excluding the conversion of the Notes and any other convertible securities issued for capital raising purposes (e.g., Simple Agreements for Future Equity)) (a “Qualified Financing”), then the outstanding

 
principal amount of this Note and any unpaid accrued interest shall automatically convert in whole without any further action by the Holder into such Equity Securities sold in the Qualified
Financing at a conversion price equal to the price paid per share for Equity Securities by the Investors in the Qualified Financing multiplied by 0.80. The issuance of Equity Securities pursuant to the conversion of this Note pursuant to this
Section 2(a) shall be upon and subject to the same terms and conditions applicable to the Equity Securities sold in the Qualified Financing. Notwithstanding this paragraph, if the conversion price of the Notes as determined pursuant to this
paragraph (the “QF Conversion Price”) is less than the price per share at which Equity Securities are issued in the Qualified Financing, the Company may, solely at its option, elect to convert this Note into
shares of a newly created series of preferred stock having the identical rights, privileges, preferences and restrictions as the Equity Securities issued in the Qualified Financing, and otherwise on the same terms and conditions, other than with
respect to: (i) the per share liquidation preference and the conversion price for purposes of price-based anti-dilution protection, which will equal the QF Conversion Price; and (ii) the per share dividend, which will be the same
percentage of the QF Conversion Price as applied to determine the per share dividends of new Investors in the Qualified Financing relative to the purchase price paid by such Investors. 

(b)    Conversion upon other Financings. In the event that the Company issues and sells Equity Securities to
Investors on or before the Maturity Date in an equity financing that does not qualify as a Qualified Financing (a “Non-Qualified Financing”), then at the option of either (x) the
Requisite Holders or (y) the Holder, the outstanding principal amount of this Note and any unpaid accrued interest shall automatically convert in whole without any further action by the Holder into such Equity Securities sold in the Non-Qualified Financing at a conversion price equal to the price paid per share for Equity Securities by the Investors in the Non-Qualified Financing multiplied by 0.80
(provided that in the event of conversion requested by the Requisite Holders, all of the Notes shall be converted upon the same terms). The issuance of Equity Securities pursuant to the conversion of this Note pursuant to this Section 2(b)
shall be upon and subject to the same terms and conditions applicable to the Equity Securities sold in the Non-Qualified Financing. Notwithstanding this paragraph, if the conversion price of the Notes as
determined pursuant to this paragraph (the “NQF Conversion Price”) is less than the price per share at which Equity Securities are issued in the Non-Qualified Financing,
then upon the conversion of this Note pursuant to this Section 2(b), the Company may, solely at its option, elect to convert this Note into shares of a newly created series of preferred stock having the identical rights, privileges, preferences
and restrictions as the Equity Securities issued in the Non-Qualified Financing, and otherwise on the same terms and conditions, other than with respect to: (i) the per share liquidation preference and
the conversion price for purposes of price-based anti-dilution protection, which will equal the NQF Conversion Price; and (ii) the per share dividend, which will be the same percentage of the NQF Conversion Price as applied to determine the per
share dividends of new Investors in the Non-Qualified Financing relative to the purchase price paid by such Investors. 

(c)    Maturity Date Conversion. In the event that this Note remains outstanding on the Maturity Date, then
the outstanding principal balance of this Note and any unpaid accrued interest shall upon the election of the Holder given prior to the Maturity Date, convert as of the Maturity Date into shares of a newly created series of the Company’s
preferred stock (the “Series C-1 Preferred”) at a conversion price equal to the price paid per share for the Company’s Series C Preferred Stock and which will have identical
rights, privileges, preferences and restrictions as the Company’s Series C Preferred Stock, other than the Series C-1 Preferred shall be entitled to no vote on any matters submitted to the Company’s
stockholders (the “Maturity Date Conversion”). The Series C-1 Preferred will be subject to the Amended and Restated Investor Rights Agreement, by and among the Company and the Investors
party thereto, dated as of December 16, 2014 (the “IRA”) and the Amended and Restated Voting Agreement, by and among the Company and the Investors party thereto, dated as of December 16, 2014 (the “Voting
Agreement”), provided, however, that the Series C-1 Preferred will not be included in the voting or amendment thresholds under such agreements. In the event of a Maturity Date
Conversion by any of the Holders of the Notes, the 

  
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Company and the Holder, and each of the Holder’s affiliates that holds any shares of capital stock of the Company as of the date of such Maturity Date Conversion, shall amend the IRA, the
Voting Agreement and the Company’s certificate of incorporation to include the Series C-1 Preferred. 

(d)    Change of Control. If the Company consummates a Change of Control (as defined below) while this Note
remains outstanding, the Company shall provide the Holder with at least ten (10) days’ prior written notice thereof and shall repay the Holder in cash in an amount equal to 150% of the outstanding principal amount of this Note plus any
unpaid accrued interest on the original principal; provided however, that, if requested in writing by (x) the Requisite Holders or (y) the Holder, in lieu of such repayment, the outstanding principal amount and unpaid accrued
interest thereon shall convert into shares of the then-most recently issued series of preferred stock of the Company issued in a bona fide equity financing transaction at a conversion price equal to the lowest price paid per share by investors in
such financing, which conversion shall take place immediately prior to the closing of such Change of Control (provided that in the event of conversion requested by the Requisite Holders, all of the Notes shall be converted upon the same terms). For
purposes of this Note, a “Change of Control” means (i) a consolidation or merger of the Company with or into any other corporation or other entity or person, or any other corporate reorganization, other than any such
consolidation, merger or reorganization in which the shares of capital stock of the Company immediately prior to such consolidation, merger or reorganization, continue to represent a majority of the voting power of the surviving entity immediately
after such consolidation, merger or reorganization; (ii) any transaction or series of related transactions to which the Company is a party in which in excess of 50% of the Company’s voting power is transferred; or (iii) the sale or
transfer of all or substantially all of the Company’s assets, or the exclusive license of all or substantially all of the Company’s material intellectual property; provided that a Change of Control shall not include any transaction
or series of transactions principally for bona fide equity financing purposes in which cash is received by the Company or any successor, indebtedness of the Company is cancelled, or converted or a combination thereof. The Company shall give the
Holder notice of a Change of Control not less than 10 days prior to the anticipated date of consummation of the Change of Control. Any repayment pursuant to this paragraph in connection with a Change of Control shall be subject to any required tax
withholdings, and may be made by the Company (or any party to such Change of Control or its agent) following the Change of Control in connection with payment procedures established in connection with such Change of Control. 

(e)    Procedure for Conversion. In connection with any conversion of this Note into capital stock, the
Holder shall surrender this Note to the Company and deliver to the Company any documentation reasonably required by the Company (including, in the case of a Qualified Financing, all financing documents executed by other investors in connection with
such Qualified Financing). The Company shall not be required to issue or deliver the capital stock into which this Note may convert until the Holder has surrendered this Note to the Company and delivered to the Company any such
documentation. Upon the conversion of this Note into capital stock pursuant to the terms hereof, in lieu of any fractional shares to which the Holder would otherwise be entitled, the Company shall pay the Holder cash equal to such fraction
multiplied by the price at which this Note converts. 
 (f)    Interest Accrual. If a Change of Control or
Qualified Financing is consummated, all interest on this Note shall be deemed to have stopped accruing as of a date selected by the Company that is not more than 10 days prior to the signing of the definitive agreement for the Change of Control or
Qualified Financing. 

  
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	 	3.	 REPRESENTATIONS AND WARRANTIES. 

(a)    Representations and Warranties of the Company. The Company hereby represents and warrants to the
Holder as of the date the first Note was issued as follows: 
 (i)    Organization, Good Standing and
Qualification. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company has the requisite corporate power to own and operate its properties and assets and to carry on
its business as now conducted and as proposed to be conducted. The Company is duly qualified and is authorized to do business and is in good standing as a foreign corporation in all jurisdictions in which the nature of its activities and of its
properties (both owned and leased) makes such qualification necessary, except for those jurisdictions in which failure to do so would not have a material adverse effect on the Company or its business. 

(ii)    Corporate Power. The Company has all requisite corporate power to issue this Note and to
carry out and perform its obligations under this Note. The Company’s Board of Directors (the “Board”) has approved the issuance of this Note based upon a reasonable belief that the issuance of this Note is appropriate
for the Company after reasonable inquiry concerning the Company’s financing objectives and financial situation. 

(iii)    Authorization. All corporate action on the part of the Company, the Board and the Company’s
stockholders necessary for the issuance and delivery of this Note has been taken. This Note constitutes a valid and binding obligation of the Company enforceable in accordance with its terms, subject to laws of general application relating to
bankruptcy, insolvency, the relief of debtors and, with respect to rights to indemnity, subject to federal and state securities laws. Any securities issued upon conversion of this Note (the “Conversion Securities”), when
issued in compliance with the provisions of this Note, will be validly issued, fully paid, nonassessable, free of any liens or encumbrances and issued in compliance with all applicable federal and securities laws. 

(iv)    Governmental Consents. All consents, approvals, orders or authorizations of, or registrations,
qualifications, designations, declarations or filings with, any governmental authority required on the part of the Company in connection with issuance of this Note has been obtained. 

(v)    Compliance with Laws. To its knowledge, the Company is not in violation of any applicable statute,
rule, regulation, order or restriction of any domestic or foreign government or any instrumentality or agency thereof in respect of the conduct of its business or the ownership of its properties, which violation of which would materially and
adversely affect the business, assets, liabilities, financial condition, operations or prospects of the Company. 

(vi)    Compliance with Other Instruments. The Company is not in violation or default of any term of its
certificate of incorporation or bylaws, or of any provision of any mortgage, indenture or contract to which it is a party and by which it is bound or of any judgment, decree, order or writ, other than such violation(s) that would not have a material
adverse effect on the Company. The execution, delivery and performance of this Note will not result in any such violation or be in conflict with, or constitute, with or without the passage of time and giving of notice, either a default under any
such provision, instrument, judgment, decree, order or writ or an event that results in the creation of any lien, charge or encumbrance upon any assets of the Company or the suspension, revocation, impairment, forfeiture, or nonrenewal of any
material permit, license, authorization or approval applicable to the Company, its business or operations or any of its assets or properties. Without limiting the foregoing, the Company has obtained all waivers reasonably necessary with respect to
any preemptive rights, rights of first refusal or similar rights, including any notice or offering periods provided for as part of any such rights, in order for the Company to consummate the transactions contemplated hereunder without any third
party obtaining any rights to cause the Company to offer or issue any securities of the Company as a result of the consummation of the transactions contemplated hereunder. 

  
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 (vii)    No “Bad Actor” Disqualification. The
Company has exercised reasonable care to determine whether any Company Covered Person (as defined below) is subject to any of the “bad actor” disqualifications described in Rule 506(d)(1)(i) through (viii), as modified by Rules 506(d)(2)
and (d)(3), under the Act (“Disqualification Events”). To the Company’s knowledge, no Company Covered Person is subject to a Disqualification Event. The Company has complied, to the extent required, with any disclosure
obligations under Rule 506(e) under the Act. For purposes of this Note, “Company Covered Persons” are those persons specified in Rule 506(d)(1) under the Act; provided, however, that Company Covered Persons do not include
(a) any Holder, or (b) any person or entity that is deemed to be an affiliated issuer of the Company solely as a result of the relationship between the Company and any Holder. 

(viii)    Offering. Assuming the accuracy of the representations and warranties of the Holder contained in
subsection (b) below, the offer, issue, and sale of this Note and any Conversion Securities are and will be exempt from the registration and prospectus delivery requirements of the Act, and have been registered or qualified (or are exempt from
registration and qualification) under the registration, permit or qualification requirements of all applicable state securities laws. 

(ix)    Use of Proceeds. The Company shall use the proceeds of this Note solely for the operation of
its business, and not for any personal, family or household purpose.  
 (b)    Representations and
Warranties of the Holder. The Holder hereby represents and warrants to the Company as of the date hereof as follows: 

(i)    Purchase for Own Account. The Holder is acquiring this Note and the Conversion Securities
(collectively, the “Securities”) solely for the Holder’s own account and beneficial interest for investment and not for sale or with a view to distribution of the Securities or any part thereof, has no present intention
of selling (in connection with a distribution or otherwise), granting any participation in, or otherwise distributing the same, and does not presently have reason to anticipate a change in such intention. 

(ii)    Information and Sophistication. Without lessening or obviating the representations and warranties
of the Company set forth in subsection (a) above, the Holder hereby: (A) acknowledges that the Holder has received all the information the Holder has requested from the Company and the Holder considers necessary or appropriate for deciding
whether to acquire the Securities, (B) represents that the Holder has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of the Securities and to obtain any additional
information necessary to verify the accuracy of the information given the Holder and (C) further represents that the Holder has such knowledge and experience in financial and business matters that the Holder is capable of evaluating the merits
and risk of this investment. 
 (iii)    Ability to Bear Economic Risk. The Holder acknowledges that
investment in the Securities involves a high degree of risk, and represents that the Holder is able, without materially impairing the Holder’s financial condition, to hold the Securities for an indefinite period of time and to suffer a complete
loss of the Holder’s investment. 

  
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 (iv)    Further Limitations on Disposition. Without in
any way limiting the representations set forth above, the Holder further agrees not to make any disposition of all or any portion of the Securities unless and until: 

(1)    There is then in effect a registration statement under the Act covering such proposed disposition and such
disposition is made in accordance with such registration statement; or 
 (2)    The Holder shall have notified
the Company of the proposed disposition and furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and if reasonably requested by the Company, the Holder shall have furnished the Company with an
opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration under the Act or any applicable state securities laws, provided that no such opinion shall be required for dispositions in compliance
with Rule 144 under the Act, except in unusual circumstances. 
 (3)    Notwithstanding the provisions of
paragraphs (1) and (2) above, no such registration statement or opinion of counsel shall be necessary for a transfer by the Holder to a partner (or retired partner) or member (or retired member) of the Holder in accordance with partnership or
limited liability company interests, or transfers by gift, will or intestate succession to any spouse or lineal descendants or ancestors, if all transferees agree in writing to be subject to the terms hereof to the same extent as if they were the
Holders hereunder. 
 (v)    Accredited Investor Status. The Holder is an “accredited investor”
as such term is defined in Rule 501 under the Act. 
 (vi)    No “Bad Actor” Disqualification.
The Holder represents and warrants that neither (A) the Holder nor (B) any entity that controls the Holder or is under the control of, or under common control with, the Holder, is subject to any Disqualification Event, except for
Disqualification Events covered by Rule 506(d)(2)(ii) or (iii) or (d)(3) under the Act and disclosed in writing in reasonable detail to the Company. The Holder represents that the Holder has exercised reasonable care to determine the accuracy
of the representation made by the Holder in this paragraph, and agrees to notify the Company if the Holder becomes aware of any fact that makes the representation given by the Holder hereunder inaccurate. 

(vii)    Foreign Investors. If the Holder is not a United States person (as defined by
Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended (the “Code”)), the Holder hereby represents that he, she or it has satisfied itself as to the full observance of the laws of the Holder’s
jurisdiction in connection with any invitation to subscribe for the Securities or any use of this Note, including (A) the legal requirements within the Holder’s jurisdiction for the purchase of the Securities, (B) any foreign exchange
restrictions applicable to such purchase, (C) any governmental or other consents that may need to be obtained, and (D) the income tax and other tax consequences, if any, that may be relevant to the purchase, holding, redemption, sale, or
transfer of the Securities. The Holder’s subscription, payment for and continued beneficial ownership of the Securities will not violate any applicable securities or other laws of the Holder’s jurisdiction. 

(viii)    Forward-Looking Statements. With respect to any forecasts, projections of results and other
forward-looking statements and information provided to the Holder, the Holder acknowledges that the Company represents to the Holder that such statements were prepared based upon assumptions deemed reasonable by the Company at the time of
preparation. There is no assurance that such statements will prove accurate, and the Company has no obligation to update such statements. 

  
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	 	4.	 EVENTS OF DEFAULT. 

(a)    If there shall be any Event of Default (as defined below) hereunder, at the option and upon the declaration
of the Requisite Holders and upon written notice to the Company (which election and notice shall not be required in the case of an Event of Default under subsection (ii) or (iii) below), this Note shall accelerate and all principal and unpaid
accrued interest shall become due and payable. The occurrence of any one or more of the following shall constitute an “Event of Default”: 

(i)    The Company fails to pay timely any of the principal amount due under this Note on the date the same
becomes due and payable or any unpaid accrued interest or other amounts due under this Note on the date the same becomes due and payable; 

(ii)    The Company files any petition or action for relief under any bankruptcy, reorganization, insolvency or
moratorium law or any other law for the relief of, or relating to, debtors, now or hereafter in effect, or makes any assignment for the benefit of creditors or takes any corporate action in furtherance of any of the foregoing; or 

(iii)    An involuntary petition is filed against the Company (unless such petition is dismissed or discharged
within 60 days under any bankruptcy statute now or hereafter in effect, or a custodian, receiver, trustee, assignee for the benefit of creditors (or other similar official) is appointed to take possession, custody or control of any property of the
Company). 
 (b)    In the event of any Event of Default hereunder, the Company shall pay all reasonable
attorneys’ fees and court costs incurred by the Holder in enforcing and collecting this Note. 
  

	 	5.	 MISCELLANEOUS PROVISIONS. 

(a)    Waivers. Company hereby waives demand, notice, presentment, protest and notice of dishonor. 

(b)    Further Assurances. The Holder agrees and covenants that at any time and from time to time the Holder
will promptly execute and deliver to the Company such further instruments and documents and take such further action as the Company may reasonably require in order to carry out the full intent and purpose of this Note and to comply with state or
federal securities laws or other regulatory approvals. 
 (c)    Transfers of Notes. This Note may be
transferred only upon its surrender to the Company for registration of transfer, duly endorsed, or accompanied by a duly executed written instrument of transfer in form satisfactory to the Company. Thereupon, this Note shall be reissued to, and
registered in the name of, the transferee, or a new Note for like principal amount and interest shall be issued to, and registered in the name of, the transferee. Interest and principal shall be paid solely to the registered holder of this Note.
Such payment shall constitute full discharge of the Company’s obligation to pay such interest and principal. 

(d)    Market Standoff. The Holder hereby agrees that the Holder shall not sell, dispose of, transfer, make
any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale of, any shares of Common Stock (or other securities) of the Company held by the Holder (other than
those included in the registration) during the 180-day period following the effective date of the initial public offering of the Company (or such longer period, not to exceed 34 days after the expiration of
the 180-day period, as the underwriters or the Company shall request in order to facilitate compliance with FINRA Rule 2241 or NYSE Member Rule 472 or any successor or

  
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similar rule or regulation). The Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the managing underwriters that are consistent with the
foregoing or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of the Company’s Common Stock (or other securities of the Company), the Holder shall provide,
within 10 days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the
Act. The obligations described in this paragraph shall not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms
that may be promulgated in the future, or a registration relating solely to a transaction on Form S-4 or similar forms that may be promulgated in the future. In order to enforce the foregoing covenant, the
Company may impose stop-transfer instructions with respect to such Common Stock (or other securities of the Company) until the end of such period. The Holder agrees that any transferee of any of the Securities (or other securities of the Company)
held by the Holder shall be bound by this paragraph. The underwriters of the Company’s stock are intended third-party beneficiaries of this paragraph and shall have the right, power and authority to enforce the provisions hereof as though they
were a party hereto.  
 (e)    Amendment and Waiver. Any term of this Note may be amended or
waived with the written consent of the Company and the Requisite Holders. Upon the effectuation of such waiver or amendment with the consent of the Requisite Holders in conformance with this paragraph, such amendment or waiver shall be effective as
to, and binding against the holders of, all of the Notes and the Company shall promptly give written notice thereof to the Holder if the Holder has not previously consented to such amendment or waiver in writing, provided that the failure to give
such notice shall not affect the validity of such amendment or waiver. 
 (f)    Governing Law. This Note
shall be governed by and construed under the laws of the State of Delaware, as applied to agreements among Delaware residents, made and to be performed entirely within the State of Delaware, without giving effect to conflicts of laws principles.

 (g)    Binding Agreement. The terms and conditions of this Note shall inure to the benefit of and be
binding upon the respective successors and assigns of the parties. Nothing in this Note, expressed or implied, is intended to confer upon any third party any rights, remedies, obligations, or liabilities under or by reason of this Note, except as
expressly provided in this Note. 
 (h)    Counterparts. This Note may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic signature complying with
the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act or other applicable law) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all
purposes. 
 (i)    Titles and Subtitles. The titles and subtitles used in this Note are used for
convenience only and are not to be considered in construing or interpreting this Note. 
 (j)    Notices.
All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (i) upon personal delivery to the party to be notified, (ii) when sent by confirmed electronic mail or facsimile if sent during normal
business hours of the recipient, if not, then on the next business day, (iii) five days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (iv) one day after deposit with a nationally
recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications to a party shall be sent to the party’s address set forth on the signature page hereto or at such other address(es) as such
party may designate by 10 days advance written notice to the other party hereto. A copy of any notice to the Company shall be sent to Cooley LLP, 3175 Hanover Street, Palo Alto, CA 94304-1130, Attn: James C. Kitch,
e-mail: kitchjc@cooley.com. 

  
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 (k)    Expenses. The Company and the Holder shall each
bear its respective expenses and legal fees incurred with respect to the negotiation, execution and delivery of this Note and the transactions contemplated herein. 

(l)    Waiver of Conflicts. Each party to this Note acknowledges that Cooley LLP
(“Cooley”), outside general counsel to the Company, has in the past performed and is or may now or in the future represent the Holder or the Holder’s affiliates in matters unrelated to the transactions contemplated by
this Note (the “Note Financing”), including representation of the Holder or the Holder’s affiliates in matters of a similar nature to the Note Financing. The applicable rules of professional conduct require that Cooley
inform the parties hereunder of this representation and obtain their consent. Cooley has served as outside general counsel to the Company and has negotiated the terms of the Note Financing solely on behalf of the Company. The Company and the Holder
hereby (i) acknowledge that they have had an opportunity to ask for and have obtained information relevant to such representation, including disclosure of the reasonably foreseeable adverse consequences of such representation;
(ii) acknowledge that with respect to the Note Financing, Cooley has represented solely the Company, and not any Holder or any stockholder, Board member or employee of the Company or director, stockholder or employee of the Holder; and
(iii) gives the Holder’s informed consent to Cooley’s representation of the Company in the Note Financing. 

(m)    Delays or Omissions. It is agreed that no delay or omission to exercise any right, power or remedy
accruing to the Holder, upon any breach or default of the Company under this Note shall impair any such right, power or remedy, nor shall it be construed to be a waiver of any such breach or default, or any acquiescence therein, or of or in any
similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. It is further agreed that any waiver, permit, consent or
approval of any kind or character by the Holder of any breach or default under this Note, or any waiver by the Holder of any provisions or conditions of this Note, must be in writing and shall be effective only to the extent specifically set forth
in writing and that all remedies, either under this Note, or by law or otherwise afforded to the Holder, shall be cumulative and not alternative. This Note shall be void and of no force or effect in the event that the Holder fails to remit the full
principal amount to the Company within five calendar days of the date of this Note. 
 (n)    Entire
Agreement. This Note constitutes the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other party in any manner by any representations, warranties,
covenants and agreements except as specifically set forth herein. 
 (o)    Exculpation among Holders. The
Holder acknowledges that the Holder is not relying on any person, firm or corporation, other than the Company and its officers and Board members, in making its investment or decision to invest in the Company. 

(p)    Senior Indebtedness. The indebtedness evidenced by this Note is subordinated in right of payment to
the prior payment in full of any Senior Indebtedness in existence on the date of this Note or hereafter incurred. “Senior Indebtedness” shall mean, unless expressly subordinated to or made on a parity with the amounts due
under this Note, all amounts due in connection with (i) indebtedness of the Company to banks or other lending institutions regularly engaged in the business of lending money (excluding venture capital, investment banking or similar institutions
and their affiliates, which sometimes engage in lending activities but which are primarily engaged in investments in equity securities), and (ii) any such indebtedness or any debentures, notes or other evidence of indebtedness issued in
exchange for such Senior Indebtedness, or any indebtedness arising from the satisfaction of such Senior Indebtedness by a guarantor. 

  
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 (q)    Broker’s Fees. Each party hereto
represents and warrants that no agent, broker, investment banker, person or firm acting on behalf of or under the authority of such party hereto is or will be entitled to any broker’s or finder’s fee or any other commission directly or
indirectly in connection with the transactions contemplated herein. Each party hereto further agrees to indemnify each other party for any claims, losses or expenses incurred by such other party as a result of the representation in this subsection
being untrue. 
 (r)    California Corporate Securities Law. THE SALE OF THE SECURITIES WHICH ARE THE
SUBJECT OF THIS AGREEMENT HAS NOT BEEN QUALIFIED WITH THE COMMISSIONER OF CORPORATIONS OF THE STATE OF CALIFORNIA AND THE ISSUANCE OF SUCH SECURITIES OR THE PAYMENT OR RECEIPT OF ANY PART OF THE CONSIDERATION THEREFOR PRIOR TO SUCH QUALIFICATION OR
IN THE ABSENCE OF AN EXEMPTION FROM SUCH QUALIFICATION IS UNLAWFUL. PRIOR TO ACCEPTANCE OF SUCH CONSIDERATION BY THE COMPANY, THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT ARE EXPRESSLY CONDITIONED UPON SUCH QUALIFICATION BEING OBTAINED OR AN
EXEMPTION FROM SUCH QUALIFICATION BEING AVAILABLE. 
 [Signature pages follow] 

  
 10 

 The parties have executed this CONVERTIBLE PROMISSORY NOTE
as of the date first noted above. 
  

			
	COMPANY:
	
	PERSONALIS, INC. 
		
	By:	 	 /s/ John West

	Name:	 	John West
	Title:	 	Chief Executive Officer
		
	E-mail:	 	  

	Address:	 	1330 O’Brien Drive
		 	Menlo Park, California 94025

  
 SIGNATURE PAGE TO 

PERSONALIS, INC. 
 CONVERTIBLE
PROMISSORY NOTE 

 The parties have executed this CONVERTIBLE PROMISSORY NOTE
as of the date first noted above. 
  

							
		 		 	HOLDER (if an entity):
			
		 	Name of Holder:	 	  

				
		 		 	By:	 	  

		 		 	Name:	 	  

		 		 	Title:	 	  

				
		 		 	E-mail:	 	  

				
		 		 	Address:	 	  

		 		 		 	  

		 		 		 	  

			
		 		 	HOLDER (if an individual):
			
		 	Name of Holder:	 	  

			
		 	Signature:	 	  

				
		 		 	E-mail:	 	  

				
		 		 	Address:	 	  

		 		 		 	  

		 		 		 	  

  
 SIGNATURE PAGE TO 

PERSONALIS, INC. 
 CONVERTIBLE
PROMISSORY NOTEEX-10.23

 Exhibit 10.23 

PERSONALIS, INC. 

AMENDMENT TO 

CONVERTIBLE PROMISSORY NOTES 

THIS AMENDMENT TO CONVERTIBLE PROMISSORY NOTES (this “Amendment”) is entered
into as of May 31st, 2018 by and among PERSONALIS, INC., a Delaware corporation
(“Company”), and each of the individuals and entities set forth on the signature pages hereto (the
“Holders”). 
 RECITALS 

A.    The Holders are holders of convertible promissory notes (each, a “Note” and
collectively, the “Notes”), by and between the Company and the Holders named therein dated June 29, 2017 (the “Agreement”) and
constitute the Requisite Holders (as defined in the Notes). 
 B.    The Notes provide that the terms of the Notes may be amended by the
Requisite Holders. 
 C.    The undersigned desire to amend the Notes to provide that the Maturity Date shall be extended to
June 28, 2019. 
 AGREEMENT 

The parties hereby agree as follows: 

1.    The Notes are hereby amended to extend the “Maturity Date” to June 28, 2019. 

2.    This Amendment shall be governed by and construed under the laws of the State of Delaware as applied to agreements
among Delaware residents, made and to be performed entirely within the State of Delaware. 
 3.    Except as provided
herein, the Notes shall remain unamended and in full force and effect. This Amendment may be executed in one or more counterparts each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

[Signature pages follow] 

  
 - 1 - 

 IN WITNESS WHEREOF, the parties have executed this Amendment to Convertible
Promissory Notes to be effective as of the date first above written. 
  

			
	COMPANY:
	
	PERSONALIS, INC.
		
	By:	 	 /s/ John West

	Name:	 	John West
	Title:	 	Chief Executive Officer

 [SIGNATURE PAGE TO AMENDMENT
TO NOTE AND WARRANT PURCHASE AGREEMENT – NOVEMBER 2017] 

 IN WITNESS WHEREOF, the parties have executed this Amendment to Convertible
Promissory Notes to be effective as of the date first above written. 
  

	
	HOLDERS:
	
	 Abingworth Bioventures V, LP

	(Print Name of Holder)
	
	 /s/ James Abell

	(Signature of Holder or of Authorized Signatory)
	
	 James Abell

	(Print Name And Title Of Authorized Signatory, If
	Applicable)

  

			
	Address:	 	38 Jermyn Street
		 	London
		 	UK SW1Y6DN

  

			
	Phone:	 	 +44 207 534 1500

	Fax:	 	+44 207 534 1539
	Email:	 	legal@abingworth.com

 [SIGNATURE PAGE TO AMENDMENT
TO NOTES] 

 IN WITNESS WHEREOF, the parties have executed this Amendment to Convertible
Promissory Notes to be effective as of the date first above written. 
  

			
	HOLDERS:
	
	 Lightspeed Venture Partners VIII, L.P.

	By:    	 	Lightspeed General Partner VIII, L.P.,
		 	Its general partner
	By:    	 	Lightspeed Ultimate General Partner VIII, Ltd.,
		 	Its general partner
	
	 /s/ Christopher Schaepe

	(Signature of Holder or of Authorized Signatory)
	
	 Christopher Schaepe

	 (Print Name And Title Of Authorized Signatory, If

Applicable)

		
	Address:	 	2200 Sand Hill Road, Suite 100
		 	Menlo Park, CA 94025
		
	Phone:	 	  

	Fax:	 	  

	Email:	 	cschaepe@lsvp.com
	
	HOLDERS:
	
	Lightspeed Venture Partners Select, L.P.
		
	By:    	 	Lightspeed General Partner Select, L.P.,
		 	Its general partner
		
	By:    	 	Lightspeed Ultimate General Partner Select, Ltd.,
		 	Its general partner
	
	 /s/ Christopher Schaepe

	(Signature of Holder or of Authorized Signatory)
	
	Christopher Schaepe
	 (Print Name And Title Of Authorized Signatory, If

Applicable)

 [SIGNATURE PAGE TO AMENDMENT
TO NOTES] 

 
			
	Address:	 	2200 Sand Hill Road, Suite 100
		 	Menlo Park, CA 94025
		
	Phone:	 	  

	Fax:	 	  

	Email:	 	cschaepe@lsvp.com

 [SIGNATURE PAGE TO AMENDMENT
TO NOTES]

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