Document:

Offer Letter by and between John G. Curd, M.D. and Novacea, Inc.

 Exhibit 10.18 
  
 D-Novo Therapeutics, Inc. 
 28202
Cabot Road, Suite 200 
 Laguna Niguel, CA 92677 
  
 December 11, 2001 
  
 John G. Curd, MD 
  
 Dear John: 
  
 I am pleased to offer you the position of President and Chief Medical Officer for D-Novo Therapeutics effective January 1, 2002. You will report to the Chief
Executive Officer. The Company will be located in the San Francisco area. 
  
 Your
base compensation will be $275,000 per year. Your annual bonus opportunity will be 25% of your base compensation ($68,750) based upon performance objectives to be mutually agreed upon. You will be issued an option to purchase up to 4.25% of the
Common Stock of the Company with vesting over a four-year period subject to approval by the Board of Directors. The 4.25% will be calculated after the Company’s Series A-2 closes in the first quarter of 2002. It is anticipated that the shares
authorized and issued at that time will be 12,800,000 (including option pool). A copy of the Incentive Stock Option Agreement and the Company’s standard form of Optionee Restriction Agreement will be provided after Board approval. 

 
 D-Novo will also provide a severance package of six (6) months’ salary if D-Novo
terminates your employment without cause. 
  
 You will be entitled to twenty
(20) days vacation each year, accruing on a monthly basis, one (1) personal day and eight (8) holidays. You will be eligible for fringe benefits established by the Company and approved by the Board. 
  
 The Company will reimburse you for all reasonable and necessary out-of-pocket expenses
incurred by you in connection with services rendered on behalf of the Company subject to your providing the Company with appropriate substantiation in accordance with Company policy. 
  
 Upon commencement of your employment, you and the Company will execute a Patent, Copyright and Non-disclosure Agreement and such other
agreements as 

 
set forth in the Employee Handbook. Your employment is at will, which means that either you or the Company may terminate it at any time, with or without
cause for any reason or no reason what so ever. 
  
 John, this is a very exciting
opportunity to build a company from the ground floor. I am looking forward to your contributions to our success. If this offer meets with your approval, please sign where indicated below and return to me no later than December 20, 2001.

  

	
	 Sincerely,

	
	/s/ Eckard Weber
	 Eckard Weber, M.D.
 CEO and President

	  
 Agreed and
accepted:

	
	/s/ John G. Curd
	 John G. Curd, MD

	
	December 20, 2001
	 DateOffer Letter by and between Edward Albini and Novacea, Inc.

 Exhibit 10.19 
  
 Novacea 
 601 Gateway Blvd., Suite 800 
 So. San Francisco, CA 94080 
 650.228.1800 
  
 January 28, 2004 
  
 Mr. Edward Albini 
  
 Dear Ed:

  
 I am pleased to offer you the position of Vice President and Chief Financial
Officer for Novacea effective on or before March 1, 2004, reporting to me. In this role you will be responsible for Finance, IT and Facilities. As we are a small company, you will also likely be asked to assist in other matters to which you can
lend your expertise. 
  
 Your base compensation will be $225,000 per year. Your
annual bonus opportunity will be up to 20% based upon company performance and individual performance objectives to be mutually agreed upon. Subject to the approval of the Board of Directors, you will be issued an option to purchase up to 350,000
shares of the Common Stock of the Company with vesting over four years: 25% at the end of 12 months and then monthly thereafter. A copy of the Incentive Stock Option Agreement and the Company’s standard form of Optionee Restriction Agreement
will be provided after approval by the Board. 
  
 You will be entitled to fifteen
(15) days vacation each year, accruing on a monthly basis and as well as all company paid holidays. You will be eligible for fringe benefits established by the Company and approved by the Board, which currently include medical, dental, vision,
life and a 401 (k) plan. 
  
 Novacea will reimburse you for all reasonable
and necessary out-of-pocket expenses incurred by you in connection with services rendered on behalf of Novacea, subject to your providing appropriate substantiation in accordance with Company policy. 

 Upon commencement of your employment, you and the Company will execute a Patent, Copyright and Non-disclosure Agreement
and such other agreements as set forth in the Employee Handbook. Your employment is at will, which means that either you or the Company may terminate it at any time, with or without cause for any reason or no reason what so ever; this provision can
not be waived by Novacea unless done in writing by the Chief Executive Officer. 
  
 Ed, this is a very exciting opportunity: there is good science supporting the drugs we are developing, a real possibility of changing the way we treat cancer, the opportunity to create a “world class” development and
commercialization organization and a terrifically successful company. If you accept this offer, please sign and return one copy, keeping one copy for your files. 
  
 I look forward to your response by the end of the week. Even more, I look forward to your joining this team and to your contributing to our
success. 
  

	
	Sincerely,
	
	/s/ Brad Goodwin
	Brad Goodwin
	CEO

  

			
		
	Accepted by:	 	/s/ Edward C. Albini

			
	Date:	 	2/26/04Offer Letter by and between Fong W. Clow D.Sc. and Novacea, Inc.

 Exhibit 10.20 
  
 [Company Letter Head] 
  
 March 7, 2005 
  
 Fong Wang Clow, D.Sc. 
  
 Dear Fong: 
  
 I am pleased to offer you the position of Vice President of Biometrics and Strategic Design for Novacea effective March 14, reporting to me as President and CMO.
Your position responsibilities for the first 3-6 months are delineated on Attachment A. A “Career Development Plan” is also outlined on Attachment B. 
  

Your base compensation will be $10,416.67 per pay period (semi-monthly) which equates to $250,000.00 annualized. Your annual bonus opportunity will be up to 20% of
your earned base compensation based upon company performance and individual performance objectives to be agreed upon mutually. In addition, you will be paid a one-time, sign-on bonus of $25,000.00 following your effective date of hire. Subject to
the approval of the Board of Directors, you will be issued an option to purchase 400,000 shares of the Common Stock of the Company with vesting over four years: 25% at the end of 12 months and then monthly thereafter. A copy of the Incentive Stock
Option Agreement and the Company’s standard form of Optionee Restriction Agreement will be provided after approval by the Board. 
  
 Effective with your hire date, you will be eligible to earn twenty-one (21) Paid Time Off or PTO days, accruing every pay period and subject to a maximum balance of
37 days, as well as all company paid holidays. We arc enclosing a copy of the 2005 Your Benefits overview. Please note that fringe benefits established by the Company and approved by the Board, which currently include medical, dental, vision,
life/AD&D and disability benefits, start on the first of the month following your date of hire, or April 1, 2005. Eligibility for the 401 (k) plan starts the first day of the following quarter after completing 30 days of employment
(July 1, 2005). You should confirm the end date of health coverage from your prior employer by providing us your Certificate of Health Coverage. 
  
 Novacea will reimburse you for all reasonable and necessary out-of-pocket expenses incurred by you in connection with services rendered on behalf of Novacea, subject to
you providing appropriate substantiation in accordance with Company policy. 
  
 Under immigration law, we are required to verify each new employee’s identity and legal authority to work in the United States. Accordingly, please be prepared to furnish appropriate documents satisfying those requirements no later
than 72 hours of your start date. This offer of employment is conditioned upon satisfactory documentation. 

 This letter, the attached Patent, Copyright and Non-Disclosure Agreement, and such other agreements as set forth
in the Employee Handbook, constitute all agreements with respect to your employment. However, Novacea may, in its sole discretion, adjust the compensation and benefits paid to you and its other employees. 
  
 Nothing in this document (including Attachments A & B) is intended to affect the “at
will” status of employment at Novacea. Also, management will determine, in its discretion, whether or not the criteria for promotion outlined in Attachment B has been met. Employment “at will” means that either you or the Company may
terminate your employment at any time, with or without cause for any reason or no reason whatsoever; this provision cannot be waived by Novacea unless done in writing by the CEO. 
  
 Fong, we look forward to your significant contributions in this new and critical role, as we move forward revolutionizing the way we treat
cancer, along with the opportunity to create a “world class” development and commercialization organization and a successful company. If you accept this offer, please sign and return a copy with the above referenced attachments to Laurie
De Sio. 
  

	
	 Sincerely,

	
	 /s/ John G. Curd

	 John G. Curd

	 President & Chief Medical Officer

  

	cc:	Human Resources 

  
 Attachments: 
  
 A – Position Responsibilities 
  
 B – Career Development Plan 
  
 C – Patent, Copyright and Non-Disclosure Agreement 
  

							
				
	Accepted: 	 	 /s/ Fong Wang Clow, D.Sc.
	 	 	 	 Date: 12/3/05

	 	 	 Fong Wang Clow, D.Sc.
	 	 	 	 March 12, 2005Offer Letter by and between Ivy Ang and Novacea, Inc.

 Exhibit 10.21 
  
 July 14, 2005 
  
 Ivy Ang 
  
 Dear Ivy: 
  
 I am pleased to offer you the position of Vice President of Human Resources for Novacea effective August 1, 2005 reporting to me. You will be responsible for human
resources and organizational development. As we are a dynamic organization, you may also be involved in other matters to which you can lend your expertise. 
  
 Your base compensation will be $6,270.83 per pay period (semi-monthly) which equates to $150,500.00 annualized for 70% time ($215,000 on a full time basis). Your annual
bonus opportunity will be up to 20% of your earned base compensation based upon company performance and individual performance objectives to be agreed upon mutually. In addition, you will be paid a one-time, sign-on bonus of $20,000.00 following
your effective date of hire. If you voluntarily leave the Company within one year of your hire date, you will be required to immediately pay back this lump sum amount to the Company. Subject to the approval of the Board of Directors, you will be
issued an option to purchase 220,000 shares of the Common Stock of the Company with vesting over four years: 25% at the end of 12 months and then monthly thereafter. A copy of the Incentive Stock Option Agreement and the Company’s standard form
of Optionee Restriction Agreement will be provided after approval by the Board. 
  
 Effective with your hire date, you will be eligible to earn twenty-one (21) Paid Time Off or PTO days, accruing every pay period and subject to a maximum balance of 37 days, as well as all company paid holidays. We are enclosing a copy
of the 2005 Your Benefits overview. Please note that fringe benefits established by the Company, which currently include medical, dental, vision, life/AD&D and disability benefits, start on the first of the month following your date of
hire, or September 1, 2005. Eligibility for the 401(k) plan starts the first day of the following quarter after completing 30 days of employment (October 1, 2005). You should confirm the end date of health coverage from your prior employer by
providing us your Certificate of Health Coverage. 
  
 Novacea will reimburse you
for all reasonable and necessary out-of-pocket expenses incurred by you in connection with services rendered on behalf of Novacea, subject to you providing appropriate substantiation in accordance with Company policy. 
  
 Under immigration law, we are required to verify each new employee’s identity and legal
authority to work in the United States. Accordingly, please be prepared to furnish appropriate documents satisfying those requirements no later than 72 hours of your start date. This offer of employment is conditioned upon satisfactory
documentation. 

 This letter, the attached Patent, Copyright and Non-Disclosure Agreement, and such other agreements as set forth
in the Employee Handbook, constitute all agreements with respect to your employment. However, Novacea may, in its sole discretion, adjust the compensation and benefits paid to you and its other employees. 
  
 Your employment is at will, which means that either you or the Company may terminate your
employment at any time, with or without cause for any reason or no reason whatsoever. This employment at-will provision cannot be waived by Novacea unless done in writing by me as the CEO. 
  
 Ivy, we look forward to your significant contributions in this critical role, as we move
forward revolutionizing the way we treat cancer, along with the opportunity to create a uniquely successful licensing, development and commercialization organization. If you accept this offer, please sign and return a copy with the above referenced
attachments to Laurie De Sio in Human Resources (her confidential fax: 650-228-1084). 
  

	
	 Sincerely,

	
	 /s/ Brad Goodwin

	 Brad Goodwin

	 CEO

  
 cc:
Human Resources 
  
 Attachment: 
 Patent, Copyright and Non-Disclosure Agreement 
  

							
				
	 Accepted: 
	 	 /s/ Ivy Ang
	 	 	 	Date: July 22, 2005
	 	 	 Ivg Ang

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