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                                                                   EXHIBIT 10.21

                                  SCIQUEST.COM
                         STRATEGIC PURCHASING AGREEMENT

     This STRATEGIC PURCHASING AGREEMENT is made effective as of
                                                                ---------------
("Effective Date"), by and between Buyer Company, a Delaware corporation
("Buyer" or "you") and SciQuest.com, Inc., a Delaware corporation ("SciQuest").
In consideration of the mutual covenants contained herein and other good and
valuable consideration, the parties agree as follows.

1.  Background.  SciQuest is in the business of providing an online
distribution and ordering system for scientific and laboratory products
("SciQuest Marketplace"), which includes listings of products ("Products") of
certain third party manufacturers and suppliers ("Suppliers") who have entered
into a Supplier Services Agreement with SciQuest. Buyer desires to purchase
Products of certain Suppliers from SciQuest through the SciQuest Marketplace and
SciQuest desires to sell such products to Buyer. Additionally, the parties wish
to create a mutually beneficial strategic alliance under the terms of this
Agreement and the attached Exhibits.

2.  Buyer Purchasing Site. SciQuest shall create, develop and maintain a
private purchasing site accessible by Buyer ("Buyer Site"). The Buyer Site shall
be a Buyer-specific version of the SciQuest Marketplace. SciQuest shall have
control over the development of the Buyer Site subject to Buyer's final approval
with respect to the Buyer-specific customization of the aesthetic look and feel
of the Buyer Site and the use of any tradenames, trademarks, logos or other
marks of Buyer, which shall not be unreasonably withheld.

3.  Use of the SciQuest Marketplace.  SciQuest agrees to provide Buyer access
to and use of the SciQuest Marketplace through the Buyer Site, and Buyer agrees
to utilize the SciQuest Marketplace for its purchasing needs for scientific and
laboratory products in accordance with the terms of this Agreement. From time to
time Buyer may supply (subject to existing confidentially obligations between
Buyer and its suppliers) SciQuest a list of Suppliers from which Buyer wishes to
purchase through the Buyer Site ("Buyer Designated Suppliers"). If Buyer has a
purchasing arrangement with any Buyer Designated Supplier, Buyer shall authorize
SciQuest to act for the benefit of Buyer under such arrangement, and shall
assist SciQuest in entering into an agreement for purchase and resale with such
Buyer Designated Supplier.

4.  Prices; Invoicing; Taxes.  The prices for Products listed in the Buyer
Site shall not exceed the Supplier's published list price of such Products. Upon
written notice to SciQuest from any Buyer Designated Supplier, SciQuest shall
offer to Buyer Buyer's negotiated discounts and/or prices from such Supplier for
Products purchased through the Buyer Site. SciQuest shall send a summary invoice
on a monthly basis. Buyer shall pay SciQuest within ten (10) days of the receipt
of invoice. Any payment not made within thirty (30) days from the due date shall
accrue the lessor rate of 1 1/2 percent per month from due date or the maximum
amount allowable under applicable law. All prices are in U.S. dollars and
exclusive of any sales/use taxes or similar charges assessed against Buyer's
purchase of Products. Buyer agrees to be directly responsible for such sales/use
taxes or similar charges, and any interest or penalties assessed, and will
reimburse and indemnify SciQuest for all such sales/use taxes or similar charges
paid by us for the Products. If Buyer is exempt from sales tax, Buyer must
deliver the appropriate exemption certificate(s) to SciQuest.

5.  Additional Terms.  The parties mutually agree to the obligations, terms
and conditions set forth in Exhibit A (Additional Terms) and Exhibit B (SciQuest
Marketplace Guide).

6.  Term.  This Agreement shall commence on the Effective Date and continue in
effect for a term of three (3) years unless earlier terminated as provided
herein. This Agreement shall renew for successive one (1) year terms if so
agreed in writing by the parties. Notwithstanding the foregoing, this Agreement
shall terminate: (i) upon thirty (30) days written notice by either party if the
other party materially breaches any provision of this Agreement and such breach
remains uncured for a period of thirty (30) days after delivery of written
notice of such breach; (ii) immediately upon written notice by either party if
the other party terminates or suspends its business or operations, becomes
insolvent or makes a general assignment for the benefit of creditors or files
(or has filed against it) a petition in bankruptcy; or (iii) as otherwise set
forth in Exhibit A. No termination of this Agreement shall affect any obligation
or liability which shall have accrued prior to such termination.

7.  Confidential Information.  In the performance of this Agreement, either
party may disclose to the other certain Proprietary Information. For the
purposes of this Agreement, (i) "Proprietary Information" means Trade Secrets
and Confidential Information; (ii) "Trade Secrets" means trade secrets as
defined under the Uniform Trade Secret Act; and (iii) "Confidential Information"
means information that is of value to its owner and is treated as confidential
other than Trade Secrets. Proprietary Information includes, without limitation,
all information regarding all financial information, business plans, procedures,
formulas, discoveries, inventions, improvements, innovations, concepts and
ideas. The receiving party agrees to hold the Proprietary Information disclosed
by the other party in strictest confidence and not to, directly or indirectly,
copy, use, reproduce, distribute, manufacture, duplicate, reveal, report,
publish, disclose, cause to be disclosed, or otherwise transfer the Proprietary
Information for any purpose whatsoever other than as expressly provided by this
Agreement.

Both parties acknowledge and agree that the Proprietary Information shall remain
the sole and exclusive property of the disclosing party or a third party
providing such information to the disclosing party.  The disclosure of the
Proprietary Information does not confer upon the receiving party any license,
interest, or rights of any kind in or to the Proprietary Information, except as
expressly provided under this Agreement.  Subject to the terms set forth herein,
the receiving party shall protect the Proprietary Information of the disclosing
party with the same degree of protection and care the receiving party uses to
protect its own Proprietary Information, but in no event less than reasonable
care.  With regard to Trade Secrets, the obligations in this Section shall
continue for so long as such information constitutes a Trade Secret.  With
regard to Confidential Information, the obligations in this Section shall
continue for the longer of (i) the duration dictated under governing law, or
(ii) the term of this Agreement and for a period of five (5) years thereafter.

Nothing in this Section shall prohibit or limit the receiving party's use of
information if (i) at the time of disclosure hereunder such information is
generally available to the public; (ii) after disclosure hereunder such
information becomes generally available to the public, except through breach of
this Agreement by the receiving party; (iii) the receiving party can demonstrate
such information was in its possession prior to the time of disclosure by the
disclosing party; (iv) the information becomes available to the receiving party
from a third party which is not legally prohibited from disclosing such
information; (v) the receiving party can demonstrate the information was
developed by or for it independently without the use of such information; or
(vi) if disclosure is required under applicable law or regulation.  Neither
party shall disclose the terms of this Agreement except (i) as required by
applicable law or regulation including, without limitation, to the extent
disclosure is required in connection with filings with the Securities and
Exchange Commission, (ii) as necessary to perform its obligations or exercise
its rights hereunder, or (iii) in connection with a potential merger or sale of
all or substantially all of its assets; provided that the receiving party agrees
in writing to be bound by the restrictions of this Agreement.

8.  Limitations of Warranties and Liability.  EXCEPT AS EXPRESSLY SET FORTH IN
THIS AGREEMENT AND ALL EXHIBITS HERETO, NETHER PARTY MAKES AND SPECIFICALLY
DISCLAIMS ALL OTHER WARRANTIES AND REPRESENTATIONS, EXPRESS OR IMPLIED,
INCLUDING, BUT NOT LIMITED TO, THE

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IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE AS TO
THE SCIQUEST MARKETPLACE, THE SERVICES PROVIDED UNDER THIS AGREEMENT AND THE
PRODUCTS. Except for breaches by either party of Section 7 (Confidential
Information), in no event shall either party be liable for special, incidental,
consequential or other indirect damages arising out of or relating in any manner
to this Agreement under any cause of action, including, without limitation, lost
profits, loss of business, down time or failure to realize savings, even if the
parties have been advised of the possibility of such damages. Nothing herein
will excuse Buyer from its obligation to pay any fees due under this Agreement.

9.  Governing Law; Interpretation.  This Agreement shall be governed by the
laws of the State of North Carolina without regard to conflict of law
provisions. Headings of particular Sections are inserted only for convenience
and are not to be considered a part of this Agreement or be used to define,
limit or construe the scope of any term or provision of this Agreement. Should
any provision of this Agreement require judicial interpretation, the parties
agree that the court or arbitrators construing the same shall not apply a
presumption that the terms of this Agreement shall be more strictly construed
against one party than against another. Notwithstanding the content of any
purchase order, sale order, sale confirmation or any other document relating to
the subject matter of this Agreement, this Agreement shall take precedence over
any such document, and any conflicting, inconsistent, or additional terms
contained therein shall be null and void.

10.  Arbitration; Injunctive Relief.  Except as provided below, all disputes
or claims relating in any manner to this Agreement shall be settled by binding
arbitration in accordance with the Commercial Arbitration Rules of the American
Arbitration Association. The decision of the arbitrators shall be final and
binding upon the parties and judgment upon the award may be entered in any court
having competent jurisdiction. Notwithstanding, the parties may apply to a court
of competent jurisdiction for any appropriate equitable or injunctive relief.
The parties acknowledge that any use or threatened misuse of the Proprietary
Information of either party will cause immediate irreparable harm to the non-
breaching party for which there is no adequate remedy at law. Accordingly, the
parties agree that the non-breaching party shall be entitled to immediate and
permanent injunctive relief from a court of competent jurisdiction in the event
of any such breach or threatened breach. Nothing contained herein shall limit
either party's right to any remedies at law, including the recovery of damages.
The prevailing party in any arbitration or action for equitable relief shall be
entitled to collect its reasonable attorneys' fees and costs from the losing
party.

11.  Joint Promotions and Press Releases.  Subject to Buyer's advance written
approval as to form and content, which approval shall not be unreasonably
withheld, SciQuest may issue a press release concerning the existence of this
Agreement and the parties' business arrangement hereunder.

12.  Miscellaneous.  Neither party shall be responsible for delays or failures
to perform their respective duties and obligations hereunder to the extent that
such delays or failures result from acts of God, other catastrophic economic or
natural events or any other act beyond such party's reasonable control. Except
as provided in Exhibit B, any notice provided for under this Agreement shall be
in writing and shall be given by certified mail, return receipt requested, and
shall be deemed sufficiently given if and when received by the party to be
notified at its address set forth on the signature page hereto. Either party
may, by notice to the other, change such address at any time. Except as provided
below, neither party may assign this Agreement in whole or in part without the
prior written consent of the other party. Either party may freely assign this
Agreement in conjunction with (i) a sale of all or substantially all of its
assets, or (ii) a merger, reorganization or similar transaction. This Agreement
shall be binding on the parties hereto and their respective successors and
permitted assigns. Each party shall act solely as an independent contractor and
nothing herein shall be construed to create the relationship of partner,
principal and agent or joint venturer between Buyer and SciQuest. This Agreement
and the attached Exhibits constitute the entire agreement between the parties
with reference to the subject matter hereof, supersedes any prior agreements
with respect to such subject matter. The parties may only change or modify this
Agreement in a written instrument, signed by the parties. The invalidity or
unenforceability of any term or provision of this Agreement shall not affect the
validity or enforceability of any other term or provision. No provision of this
Agreement is intended or shall be construed to provide or create any third party
beneficiary right or any other right of any kind in any third party or any
client, customer, affiliate, insurer, lender, shareholder, partner, officer,
director, employee or agent of any party hereto, or in any other person. This
Agreement may be executed simultaneously or in two counterparts, each of which
together shall constitute one and the same instrument and shall be deemed an
original hereof. All provisions of this Agreement, which by their nature are
intended to survive the expiration or termination of this Agreement, shall
survive and remain in full force and effect. Neither SciQuest nor anyone
employed by it shall be, represent themselves as, act or purport to act as or be
deemed to be the agent, representative, employee or servant of Buyer. Buyer and
SciQuest shall each comply with all applicable governmental laws, ordinances,
codes, rules, regulations and orders in the performance of this Agreement.

                      [SIGNATURES FOLLOW ON THE NEXT PAGE]

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IN WITNESS WHEREOF, the parties have caused this Agreement to be executed by
their duly authorized representatives

BUYER COMPANY                       SciQuest.com, Inc.

By:                                 By:
   ----------------------------        -------------------------------

Name:                               Name:
     --------------------------          -----------------------------

Title:                              Title:
      -------------------------           ----------------------------

Date:                               Date:
     --------------------------           ----------------------------

Address:                            Address:  5151 McCrimmon Parkway,
                                              Suite 208
                                              Morrisville, North Carolina  27560

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                                   EXHIBIT A
                                   ---------

                                ADDITIONAL TERMS
                                ----------------

1.  Exclusivity.  During the term of this Agreement, Buyer shall SciQuest and
    the SciQuest Marketplace as its exclusive provider of an online distribution
    and ordering system for scientific and laboratory products worldwide. During
    the term of this Agreement, Buyer shall also use SciQuest as its exclusive
    third party electronic channel for marketing and selling its used,
    refurbished and surplus scientific equipment through an electronic
    distribution system.

2.  Minimum Volume.  Buyer shall use purchase a minimum of $5 million in
    "Qualified Scientific Products" through the SciQuest Marketplace in each
    calendar year or portion thereof (excluding 1999) during the term of this
    Agreement. Qualified Scientific Products shall be defined as scientific and
    laboratory products or supplies sold through the SciQuest Marketplace under
    the Standard SciQuest Supplier Agreement negotiated by SciQuest directly
    with the supplier. Buyer Subsidiaries shall be defined as any foreign or
    domestic subsidiary, including any incorporated or unincorporated company,
    joint venture or partnership, which is at least fifty percent (50%) owned,
    directly or indirectly by Buyer, or if not fifty percent (50%) owned, then
    the maximum percent ownership permitted by law in the relevant country, and
    shall include any company or enterprise which, irrespective of ownership, is
    operated by Buyer or a "Buyer Subsidiary". Only subsidiaries having the
    express authorization of Buyer shall be included.

3.  Buyer's Suppliers. Buyer shall use its best efforts to direct its Suppliers
    to use SciQuest as the third party aggregator for Buyer purchases. Buyer
    agrees to the use of customary and reasonable letters, meetings and other
    communications designed to lead to the acceptance by such suppliers of
    SciQuest as Buyer's electronic purchasing intermediary.

4.  Participation in Case Study.  Buyer shall, if it deems appropriate,
    participate in reasonable case studies to be conducted by SciQuest regarding
    electronic distribution of scientific and laboratory products and supplies
    and the SciQuest Marketplace. Buyer acknowledges that by so agreeing it may
    incur certain reasonable expenses and that the results of such case studies
    may be used by SciQuest in its marketing efforts, provided that SciQuest
    does not disclose Proprietary Information in violation of its obligations
    under this Agreement. Buyer specifically agrees to allow SciQuest to use the
    fact that Buyer is a customer of SciQuest in all reasonable business uses
    and, if specifically agreed to in writing, may consider allowing SciQuest to
    use its name in publications, etc.

5.  Promotion of SciQuest Solution. Buyer shall promote the SciQuest solution in
    the scientific and laboratory products industry, to scientific product
    suppliers and to other buyers of scientific products and supplies.

6.  Initial Warrants.  In partial consideration for Buyer performing its
    obligations under this Agreement, SciQuest shall issue to Buyer on the
    Effective Date, a warrant to acquire            shares of SciQuest common
                                        -----------
    stock at an exercise price of $0.01 per share ("Initial Warrant"). One-third
    of the Initial Warrant shall be exercisable upon each anniversary of the
    Effective Date. If there is any inconsistency between the terms of the
    Agreement and the Initial Warrant, the terms of the Initial Warrant shall
    govern.

7.  Incentive Warrants.  To encourage maximum utilization of the SciQuest
    Marketplace by Buyer, SciQuest shall issue to Buyer, on February 15th 2001,
    2002 and 2003, additional warrants to acquire that number of shares of
    SciQuest common stock determined below, at an exercise price of $
                                                                      ------
    ("Incentive Warrants"). The number of shares of common stock eligible to be
    purchased pursuant to the Incentive Warrants for each calendar year shall be
    determined as follows:

 .   For 2000 (which shall consist of the period from the Effective Date until
    December 31, 2000), the number of shares shall be equal to the quotient of
    (i) the annual volume of Qualified Scientific Products sold to Buyer through
    the SciQuest system divided by (ii)       .
                                       -------

 .   For 2001, the number of shares shall be equal to the quotient of (i) the
    annual volume of Qualified Scientific Products sold to Buyer through the
    SciQuest system less year 2000 volume) divided by (ii)       .
                                                          -------

 .   For 2002, the number of shares shall be equal to the quotient of (i) the
    annual volume of Qualified Scientific Products sold to Buyer through the
    SciQuest system less year 2001 volume) divided by (ii)        .
                                                          --------

 .  Incentive Warrants shall be exercisable upon issuance.

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8.  Termination of Warrants.  The Initial Warrant and the Incentive Warrants
    shall terminate, to the extent not already exercised, upon the earlier of
    (i) termination of the Agreement, or (ii) five years after issuance.

9.  Adjustment of Shares.  All references to share information, including number
    of shares and price per share, shall be deemed automatically adjusted to
    reflect any stock dividend, stock split, reverse stock dividend or reverse
    stock split or any recapitalization of SciQuest occurring after the
    Effective Date.

10. Successors.  All the covenants and provisions of the Initial Warrant and
    Incentive Warrants by or for the benefit of SciQuest or any holder of such
    Warrants shall bind and inure to the benefit of their respective successors
    and assigns thereunder.

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                                   EXHIBIT B
                                   ---------

                        SCIQUEST MARKETPLACE USER GUIDE
                        -------------------------------

Order acceptance: Orders will not be binding on SciQuest.com or the Suppliers
until the applicable Supplier accepts them.

Order changes, cancellations, returns and refunds: SciQuest.com will process
requests for order changes, cancellations, returns and refunds with the
applicable Supplier. All order changes, cancellations, returns or refunds are
governed by the Supplier's policies, and Buyer agrees to pay additional shipment
costs or restocking charges imposed by the Supplier.  Orders may be changed by
canceling the unwanted order by emailing Customer Care by email at
customercare@sciquest.com or calling the Customer Care Hotline at (800) 233-
-------------------------
1121, then placing a new order through the Buyer Site.   The order change or
cancellation will be processed if the order has not been shipped from the
Supplier(s).   Please address questions about order changes, cancellations and
refunds, email SciQuest.com Customer Care by email at  customercare@sciquest.com
                                                       -------------------------
or by telephone at (800) 233-1121.

Shipment: All sales are shipped FOB place of shipment unless otherwise noted.
Products will be shipped via carriers designated by SciQuest.com. The method of
shipment will be determined from information provided by you during the order
process. You will be responsible for paying shipping and freight, insurance and
other Product shipment charges. SciQuest.com will not be liable for loss, damage
or penalty resulting from delivery delays or delivery failures due to any cause
beyond reasonable control.

Title: Title to the Products will pass from the Supplier to SciQuest at the
Supplier shipping point.  Title will pass from SciQuest to you upon delivery.

Product Release: SciQuest.com serves to manage the ordering, shipping and
billing processes and has no control over the quality or safety of the Products,
the truth or accuracy of the Product listings or the ability of the Suppliers to
sell the Products listed. You release SciQuest.com and its affiliated entities,
and their officers, directors, employees, agents and successors from any
actions, claims, demands, damages, liabilities or suits of any nature in law or
in equity arising from or in connection with the Products, your use of the
Products.

Product Use: You agree and warrant that you will use the Products you order
through the Site according to all federal, state or municipal laws or
regulations. You agree to use the Products as they are intended to be used as
described in the Supplier's Product listing on the Buyer Site, on the Products'
labels or documentation, in the Supplier's catalog or in other literature
furnished to you in connection with the Products.

Certain Products contain materials that may be hazardous or harmful if misused.
You recognize and acknowledge that SciQuest does not test the Products for
safety and efficacy. You have the responsibility to understand the hazards
involved in using the Products. It is your duty to warn your employees and
auxiliary consultants of any risks involved in using or handling the Products
and you will comply with instructions for Product use furnished by Supplier. No
Products will be considered to be food, drugs or medical devices unless clearly
stated in the Product listing on the Buyer Site.

User Indemnification: You expressly agree that you will test and use any
Products and/or materials produced from the Products according to the practices
standard in the industry and in strict compliance with all applicable laws and
regulations. You agree to indemnify and hold harmless SciQuest.com, its
officers, directors, employees, agents, successor and assigns from and against
any suits losses, claims, demands, liabilities, costs and expenses, including
attorneys' fees, that they may sustain or incur as a result of any claim against
them based upon negligence, breach of warranty, strict liability in tort,
contract or any other theory of law brought by you, your customers, by auxiliary
personnel (such as freight handlers) or by other third parties arising out of,
directly or indirectly, the use of any Products or by reason of your failure to
perform your obligations described in this Agreement.

You agree to notify SciQuest.com in writing within ten (10) days of your receipt
of knowledge of any accident or incident involving any Products which results in
personal injury or damage to property. You

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will help SciQuest.com or the Supplier in the investigation and determination of
the cause of an accident and you will make available to SciQuest.com or the
Supplier all statements, reports and tests made by you or made available to you
by others. Furnishing SciQuest.com with this information and any investigation
by SciQuest.com will not constitute assumption of any liability for the accident
or incident by SciQuest.com.

Passwords and Binding Orders:
You agree:
(i) to keep your password confidential and notify SciQuest within 24 hours of
any unauthorized disclosure or use of your password. If you do not notify
SciQuest, you will be responsible for the charges incurred by the use of your
password, and
(ii) that, unless canceled or changed as set forth above, you agree that all
orders placed by you, your employees or agents shall be binding on you.

Infringement: SciQuest.com does not warrant that the use of any Products will
not infringe the claims of any United States or other country's patents,
trademarks, copyrights, trade secrets or other intellectual property rights
which cover the Product itself or its use in combination with other products or
in the operation of any process.

Product Warranty: Products purchased through the Buyer Site will be subject to
the Product warranty provided by the Supplier.  SciQuest does not provided any
Product warranties or representations to you.  You agree to deal directly with
the Supplier regarding warranty issues.

SciQuest.com Intellectual Property Rights: The graphics, images, content,
compilation, magnetic translation, digital conversion and other matters related
to the Buyer Site are protected under applicable copyright, trademark and other
proprietary rights, including but not limited to intellectual property laws. You
are not permitted to copy, redistribute, use or publish any of the content or
any part of the Site, except as required to use the Site.

SciQuest.com(R) and SciMail(R) are registered service marks of SciQuest.com. The
SciQuest.com logo is a servicemark of SciQuest.com. SciQuest.com makes use of
Suppliers' trademarks, service marks, trade names or other identifying
information ("Third Party Trademarks"), and those Third Party Trademarks remain
the sole and exclusive property of the applicable third parties.

Links: Links on the Buyer Site are provided for your convenience and
SciQuest.com does not necessarily endorse or support them. Please direct your
concerns regarding any external link to the relevant website administrator or
webmaster.

Regulatory Matters: You acknowledge that certain Products may be subject to
certain regulatory standards.

The Products listed by Suppliers may be exempt from the pre-manufacturing notice
requirements of the Toxic Substance Control Act (TSCA). The TSCA requires any
person who intends to manufacture or import a new chemical substance for a
commercial purpose to submit a pre-manufacturing notice (PMN) at least 90 days
before the substance is manufactured and/or imported. TSCA Section 5(h)(3)
exempts from PMN chemical substances that are used solely for research and
development purposes. Some of the Products listed may be exempt under this
provision and any non-exempt use may trigger PMN requirements by you. You agree
to the responsibility of understanding and adhering to the TSCA, if it is
applicable.

Material Data Safety Sheets, required by Occupational Safety and Health
Administration (OSHA), 29 CFR 1910.1200, should be sent to you directly from
Supplier with the Product. You are responsible for providing the MSDS to all
personnel who may handle and use the Product. The Supplier also provides
comprehensive warnings on the Product labels. Only qualified, trained
professionals who are familiar with the potential hazards should handle all
chemicals. The absence of warnings should not be interpreted to mean that the
products have no risks upon exposure. If there is little or no health and safety
information available on any of the Products, you are responsible to follow
standard laboratory safety procedures and avoid any contact with the Products.

                                       7
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Certain Products may be subject to the control of the Nuclear Regulatory
Commission ("NRC"). If you purchase any radioactive compounds or other Products
under the control of the NRC, you agree that you are authorized to purchase
those Products and that you hold the proper government approvals, certificates
and authorizations required to make those purchases.

Only Products labeled with USP, NF and FCC designations are offered for use in
food, drug and cosmetic products.

Notice: Unless stated otherwise, all notices relating to your orders will be
sent by email:
(i) by you, to customercare@sciquest.com or
               -------------------------
(ii) by SciQuest.com, to the email address you provide in writing.

E-mail notices will be read within 24 hours after they are sent, unless the
sender is notified that the email address is invalid or returned undeliverable.
Alternatively, SciQuest.com may provide notice as otherwise provided in the
Agreement.

                                       8<PAGE>

                                                                   EXHIBIT 10.22

                         REGISTRATION RIGHTS AGREEMENT

     THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made and entered
into as of this 14th day of January 2000, by and among SCIQUEST.COM, INC., a
Delaware corporation (the "Company"), and the undersigned holders of Common
Stock of the Company (individually, a "Holder" and collectively, the "Holders").

     WHEREAS, pursuant to the terms of the Merger Agreement (the "Merger
Agreement") dated January 14, 2000, by and among the Company, Lujack
Subsidiary, Inc., a Delaware corporation, and Intralogix, Inc., an Illinois
corporation, the Holders are acquiring an aggregate of 26,930 shares (the
"Shares"), of the Company's Common Stock, $0.001 par value per share (the
"Common Stock"); and

     WHEREAS, the Company has agreed to provide the Holders with certain rights
relating to the registration and sale of the Shares.

     NOW, THEREFORE, in consideration of the covenants and promises contained
herein, the parties agree as follows:

                        ARTICLE 1 - REGISTRATION RIGHTS
                        -------------------------------

     1.1  Definitions.  For purposes of this Article 1, the following terms
          -----------
shall have the following respective meanings:

     (a)  "Act" shall mean the Securities Act of 1933, as amended, or any
similar federal statute enacted hereafter, and the rules and regulations of the
Commission thereunder, all as the same shall be in effect from time to time.

     (b)  "Commission" shall mean the Securities and Exchange Commission or any
other federal agency at the time administering the Act.

     (c)  "Common Stock" shall mean the Common Stock, $.001 par value per share,
of the Company.

     (d)  The terms "register," "registered" and "registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the Act and the declaration or ordering of effectiveness of such
registration statement by the Commission.

     (e)  "Registrable Securities" shall mean (i) shares of Common Stock issued
or issuable upon conversion of the Shares and (ii) any other shares of Common
Stock issued in respect of the Shares (on account of stock splits, stock
dividends, reclassifications, recapitalizations or similar events); provided,
                                                                    --------
however, that shares of Common Stock which are Registrable Shares shall cease to
-------
be Registrable Shares (i) upon any sale pursuant to a Registration Statement or
Rule 144 under the Act, (ii) upon any sale in any manner to a person or entity
which, by virtue of Section
<PAGE>

1.10 of this Agreement, is not entitled to the rights provided by this
Agreement, or (iii) with respect to each Holder, at such time as such Holder's
Registrable Securities may be sold pursuant to Rule 144 without holding period
or volume limitations.

     1.2  Piggyback Registration.  Subject to Section 1.8 of this Agreement, if
          ----------------------
at any time the Company proposes to register any of its securities under the
Act, either for its own account or for the account of others, in connection with
the public offering of such securities solely for cash, on a registration form
that would also allow the registration of the Registrable Securities, the
Company shall, each such time, promptly give each Holder written notice of such
proposed registration. This provision shall not apply to a registration solely
of securities issued or issuable in connection with any stock option plan or
other employee benefit plan or in connection with a merger or acquisition. Upon
receipt by the Company of the written request of any Holder given within twenty
(20) days after mailing of any such notice by the Company, the Company shall use
its best efforts to cause to be included in such registration under the Act all
the Registrable Securities that each such Holder has requested be registered.

     1.3  Obligations of the Company.  Whenever required under this Agreement to
          --------------------------
use its best efforts to effect the registration of any Registrable Securities,
the Company shall, as expeditiously as reasonably possible:

     (a)  Prepare and file with the Commission a registration statement covering
such Registrable Securities and use its best efforts to cause such registration
statement to be declared effective by the Commission as expeditiously as
possible and to keep such registration effective until the earlier of (i) the
date when all Registrable Securities covered by the registration statement have
been sold or (ii) 180 days from the effective date of the registration
statement.

     (b)  Prepare and file with the Commission such amendments and post-
effective amendments to such registration statement as may be necessary to keep
such registration statement effective during the period referred to in Section
1.3(a) and to comply with the provisions of the Act with respect to the
disposition of all securities covered by such registration statement, and cause
the prospectus to be supplemented by any required prospectus supplement, and as
so supplemented to be filed with the Commission pursuant to Rule 424 under the
Act.

     (c)  Furnish to the selling Holders such numbers of copies of such
registration statement, each amendment thereto, the prospectus included in such
registration statement (including each preliminary prospectus), and each
supplement thereto as they may reasonably request in order to facilitate the
disposition of Registrable Securities owned by them.

     (d)  Use its best efforts to register and qualify the Registrable
Securities under the securities laws of such jurisdictions in which the Company
shall also register securities to be sold by the Company pursuant to the same
registration under the Act.

     (e)  Promptly notify each selling Holder of such Registrable Securities at
any time when a prospectus relating thereto is required to be delivered under
the Act of the happening of any event as a result of which the prospectus
included in such registration statement contains an

                                       2
<PAGE>

untrue statement of a material fact or omits any fact necessary to make the
statements therein not misleading and, at the request of any such Holder, the
Company will prepare promptly a supplement or amendment to such prospectus so
that, as thereafter delivered to the purchasers of such Registrable Securities,
such prospectus will not contain an untrue statement of a material fact or omit
to state any fact necessary to make the statements therein not misleading.

     (f)  Provide a transfer agent for all such Registrable Securities not later
than the effective date of such registration statement.

     (g)  Enter into underwriting agreements and related agreements in customary
form for any primary offering.

     (h)  Promptly notify the selling Holders of Registrable Securities and the
underwriters, if any, of the following events and (if requested by any such
person) confirm such notification in writing: (1) the filing of the prospectus
or any prospectus supplement and the registration statement and any amendment or
post-effective amendment thereto and, with respect to the registration statement
or any post-effective amendment thereto, the declaration of the effectiveness of
such documents, (2) any requests by the Commission for amendments or supplements
to the registration statement or the prospectus or for additional information,
(3) the issuance of any stop order suspending the effectiveness of the
registration statement, and (4) the receipt by the Company of any notification
with respect to the suspension of the qualification of the Registrable
Securities for sale in any jurisdiction.

     (i)  Whenever any provision of this Agreement requires the Company to
furnish any information to the Holders or the agents or representatives of the
Holders, the Company may require any such person or entity to execute and
deliver a reasonable confidentiality agreement, agreement to refrain from
trading or any other agreement necessary or prudent to protect the Company or
its officers, directors and employees against insider trading liabilities and
may restrict access to confidential trade secret information.

     1.4  Furnish Information.  In the event of any registration by the Company,
          -------------------
the Holders shall furnish to the Company such information regarding them, the
Registrable Securities and other securities of the Company held by them, and the
intended method of disposition of such Registrable Securities as the Company
shall reasonably request and as shall be required in connection with the action
to be taken by the Company.  It shall be a condition precedent to the obligation
of the Company to include any Registrable Securities of an Holder in a
registration effected pursuant to this Agreement for such Holder to have
provided the Company with such written information regarding the registration of
such Registrable Securities as the Company shall reasonably request.

     1.5  Suspension of Disposition of Registrable Securities.  Each selling
          ---------------------------------------------------
Holder of Registrable Securities agrees by acquisition of such Registrable
Securities that, upon receipt of any notice from the Company of the happening of
any event of the kind described in Section 1.3(e) or 1.3(h)(2), 1.3(h)(3) or
1.3(h)(4) hereof, such Holder will forthwith discontinue disposition of
Registrable Securities until such Holder's receipt of copies of a supplemented
or

                                       3
<PAGE>

amended prospectus contemplated by Section 1.3(e) hereof, or until it is advised
in writing by the Company that the use of the prospectus may be resumed, and has
received copies of any additional or supplemental filings which are incorporated
by reference in the prospectus, or in the case of Section 1.3(h)(2), 1.3(h)(3)
or 1.3(h)(4), until the Company notifies the Holder in writing that sales of
Registrable Securities may continue. If so directed by the Company, such Holder
will deliver to the Company (at the expense of the Company) all copies, other
than permanent file copies then in such Holder's possession, of the prospectus
covering such Registrable Securities current at the time of receipt of such
notice.

     1.6  Expenses of Registration.
          ------------------------

     The Holders shall bear the fees and expenses of their own counsel and shall
bear any additional registration and qualification fees and expenses (including
underwriters' discounts and commissions and transfer taxes), and any additional
costs and disbursements of counsel for the Company that result solely from the
inclusion of Registrable Securities held by the Holders in such registration,
with such additional expenses of the registration being borne by all selling
Holders pro rata on the basis of the total number of Registrable Securities so
registered; provided, however, that if any such cost or expense is attributable
solely to one selling Holder and does not constitute a normal cost or expense of
a registration, such cost or expense shall be allocated solely to that selling
Holder.  All other expenses of such registrations shall be borne by the Company.

     1.7  Underwriting Requirements; Priorities.
          -------------------------------------

     (a)  The Company shall have the right to select the investment banker(s)
and/or manager(s) to administer any offering to which this Agreement is
applicable. If a registration is an underwritten registration, and the managing
underwriters advise the Company in writing that in their opinion the number of
securities requested to be included in such registration exceeds the number
which can be sold at the desired price in such offering, the Company will
include in such registration (i) first, securities the Company proposes to sell,
(ii) second, the securities requested to be included therein by holders of
securities with contractual registration rights that are senior to those of the
Holders, pro rata among the holders of such securities on the basis of the
number of shares requested to be included therein, (iii) third, the securities
requested to be included therein by Holders and by the holders of securities
with contractual registration rights that are in parity with the rights of the
Holders, pro rata among such Holders and other holders on the basis of the
number of shares requested to be included therein, and (iv) fourth, other
securities requested to be included in such registration, including securities
to be sold by holders without contractual registration rights.

     (b)  No Holder may participate in any underwritten registration hereunder
unless such Holder (i) agrees to sell such Holder's securities on the basis
provided in any underwriting arrangements approved by the persons entitled
hereunder to approve such arrangements and (ii) completes and executes all
questionnaires, powers of attorney, indemnities, underwriting agreements and
other documents required under the terms of such underwriting arrangements.

                                       4
<PAGE>

     1.8  Limitation of the Company's Obligations.
          ---------------------------------------

     (a)  The Company may, in its sole discretion, postpone or withdraw any
registration in which Registrable Securities have been included pursuant to this
Agreement without obligation to the Holders.

     (b)  The Company shall not be obligated under this Agreement to register or
include in any registration Registrable Securities that any Holder has requested
to be registered if the Company shall furnish such Holder with a written opinion
of counsel reasonably satisfactory to such Holder, that all Registrable
Securities that such Holder holds may be publicly offered, sold and distributed
without registration under the Act pursuant to Rule 144 promulgated by the
Commission under the Act in any three-month period without restriction as to the
amount of securities that can be sold.

     (c)  The Company may, in its sole discretion, grant to any owner of
securities of the Company registration rights of any kind or nature.

     1.9  Lock-up Agreement.  For so long as a Holder has the right to have
          -----------------
Registrable Securities included in any registration pursuant to this Agreement,
the Holder agrees in connection with any registration of the Company's
securities, upon the request of the underwriters managing any underwritten
offering of the Company's securities, not to sell, make any short sale of,
pledge, grant any option for the purchase of or otherwise dispose of any
Registrable Securities (other than those included in the registration) without
the prior written consent of the Company or such underwriters, as the case may
be, during the seven (7) days prior to and during the 180-day period beginning
on the effective date of such registration, as the Company or the underwriters
may specify.  This provision shall apply whether or not any Registrable
Securities of the Holder are included in the offering.

     1.10 Transfer of Registration Rights.  Provided that the Company is given
          -------------------------------
written notice by the Holder at the time of such transfer stating the name and
address of the transferee and identifying the securities with respect to which
the rights under this Agreement are being assigned and such transferee agrees in
writing to be bound by the terms of this Agreement, the registration rights
under this Agreement may be transferred in whole or in part at any time to any
transferee of Registrable Securities.  Upon such transfer, the transferee shall
be deemed to be a Holder for all purposes hereunder.

     1.11 Indemnification and Contribution. In the event any Registrable
          --------------------------------
Securities are included in a registration statement under this Agreement:

     (a)  To the fullest extent permitted by law, the Company will, and hereby
does, indemnify and hold harmless each Holder whose Registrable Securities are
included in a registration, each director, officer, partner, employee, or agent
for such Holder, any underwriter (as defined in the Act) for such Holder, and
each person, if any, who controls such Holder or underwriter within the meaning
of the Act, against any losses, claims, damages or liabilities, joint or
several, to which they may become subject under the Act and applicable state
securities

                                       5
<PAGE>

laws insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based on any untrue or alleged untrue
statement of any material fact contained in such registration statement,
including any preliminary prospectus or final prospectus contained therein or
any amendments or supplements thereto, or arise out of or are based upon the
omission or alleged omission to state therein a material fact required to be
stated therein in light of the circumstances under which they were made or
necessary to make the statements therein not misleading or arise out of any
violation by the Company of any rule or regulation promulgated under the Act
applicable to the Company and relating to action or inaction required of the
Company in connection with any such registration; and will reimburse each such
person or entity for any legal or other expenses reasonably incurred by them in
connection with investigating or defending any such loss, claim, damage,
liability, or action; provided, however, that the indemnity shall not apply to
amounts paid in settlement of any such loss, claim, damage, liability, or action
if such settlement is effected without the consent of the Company (which consent
shall not be unreasonably withheld) nor shall the Company be liable in any such
case for any such loss, claim, damage, liability or action to the extent that it
arises out of or is based upon an untrue statement or alleged untrue statement
or omission or alleged omission made in connection with such registration
statement, preliminary prospectus, final prospectus, or amendments or
supplements thereto, in reliance upon and in conformity with written information
furnished expressly for use in connection with such registration by or on behalf
of any such Holder, underwriter or controlling person.

     (b)  To the fullest extent permitted by law, each Holder whose Registrable
Securities are included in a registration under this Agreement, severally and
not jointly, will, and hereby does, indemnify and hold harmless the Company,
each of its directors, each of its officers who have signed the registration
statement, each person, if any, who controls the Company within the meaning of
the Act, and any underwriter for the Company (within the meaning of the Act),
each other selling Holder and each person, if any, who controls such other
selling Holder or underwriter within the meaning of the Act against any losses,
claims, damages or liabilities, joint or several, to which the Company or any
such director, officer, controlling person, selling Holder or underwriter may
become subject, under the Act and applicable state securities laws, insofar as
such losses, claims, damages or liabilities (or actions in respect thereof)
arise out of or are based upon any untrue statement or alleged untrue statement
of any material fact contained in such registration statement, including any
preliminary prospectus or final prospectus contained therein or any amendments
or supplements thereto, or arise out of or are based upon the omission or
alleged omission to state therein a material fact required to be stated therein
or necessary to make the statements therein not misleading in light of the
circumstances, in each case to the extent, but only to the extent, that such
untrue statement or alleged untrue statement or omission or alleged omission was
made in such registration statement, preliminary or final prospectus, or
amendments or supplements thereto, in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection
with such registration; and each such Holder will reimburse any legal or other
expenses reasonably incurred by the Company or any such director, officer,
controlling person, selling Holder or underwriter in connection with
investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the indemnity shall not apply to amounts paid in
settlement of any such loss, claim, damage,

                                       6
<PAGE>

liability or action if such settlement is effected without the consent of such
Holder (which consent shall not be unreasonably withheld).

     In no event shall the liability by reason of this contractual indemnity of
any selling Holder hereunder be greater than the dollar amount of the proceeds
received by such Holder upon the sale of the Registrable Securities giving rise
to such indemnification obligation. Any Holder required to indemnify the Company
as provided above shall cease to have the right to participate in any other
registration pursuant to this Agreement.

     (c)  In order to provide for just and equitable contribution to joint
liability under the Act in circumstances in which the indemnity provisions
provided for in this section are for any reason held to be unavailable to the
indemnified parties although applicable in accordance with its terms; then, in
each such case, the Company and such Holder will contribute to the aggregate
losses, claims, damages or liabilities to which they may be subject (after
contribution from others) in such proportions as shall be appropriate to reflect
the relative fault of the Company, on the one hand, and the Holder, on the other
hand, with such relative fault determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission or alleged omission to state a material fact relates to information
supplied by the Company or by the Holder, and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission; provided, however, that, in any such case, (A) no such
                       --------  -------
Holder will be required to contribute any amount in excess of the proceeds to it
of all Registrable Securities sold by it pursuant to such registration
statement, and (B) no person or entity guilty of fraudulent misrepresentation,
within the meaning of Section 11(f) of the Act, shall be entitled to
contribution from any person or entity who is not guilty of such fraudulent
misrepresentation.

                           ARTICLE 2 - MISCELLANEOUS
                           -------------------------

     2.1  Amendments and Waivers. The provisions of this Agreement, including
          ----------------------
the provisions of this sentence, may be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may be given, by
written consent of the Company and the Holders of at least fifty five percent
(55%) of the outstanding Registrable Securities; provided, that this Agreement
                                                 --------
may be amended with the consent of the holders of less than all Registrable
Securities only in a manner which affects all Registration Securities in the
same fashion.  No waivers of or exceptions to any term, condition or provision
of this Agreement, in any one or more instances, shall be deemed to be, or
construed as, a further or continuing waiver of any such term, condition or
provision.

     2.2  Counterparts.  This Agreement may be executed in any number of
          ------------
counterparts and by the parties hereto in separate counterparts, each of which
when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

                                       7
<PAGE>

     2.3  Headings.  The headings in this Agreement are for convenience of
          --------
reference only and shall not limit or otherwise affect the meaning hereof.

     2.4  Notices.  All notices required or permitted to be sent shall be sent
          -------
to the addresses of the parties set forth on their respective signature pages,
or to such other address as any party shall provide to the other parties in a
notice sent in accordance with this Agreement. Any notice sent by registered or
certified mail, return receipt requested, or by Federal Express or other
reputable nationwide overnight delivery service, shall be deemed to have been
received by the party to whom it was sent upon receipt of confirmation of
delivery if sent by registered or certified mail and one day following the date
it was sent if sent by Federal Express or other reputable nationwide overnight
delivery service. Any notice sent by any other means shall be deemed to have
been received when it is actually received at the address provided above.

     2.5  Governing Law.  This Agreement shall be governed by and construed in
          -------------
accordance with the laws of the State of North Carolina.

     2.6  Severability.  In the event that any one or more of the provisions
          ------------
contained herein, or the application thereof in any circumstance, is held
invalid, illegal or unenforceable, the validity, legality and enforceability of
any such provision in every other respect and of the remaining provisions
contained herein shall not be affected or impaired thereby.

     2.7  Entire Agreement.  This Agreement is intended by the parties as a
          ----------------
final expression of their agreement and intended to be a complete and exclusive
statement of the agreement and understanding of the parties hereto in respect of
the subject matter contained herein.  There are no restrictions, promises,
warranties or undertakings, other than those set forth or referred to herein
with respect to the registration rights granted by the Company with respect to
the Registrable Securities.  This Agreement supersedes all prior agreements and
understandings between the parties with respect to such subject matter.  Nothing
in this Agreement shall preclude the Company from entering into any other
agreement having the same or different terms with any Holder or any third party
with respect to registration rights or related matters.

     2.8  Parties Benefited.  Nothing in this Agreement, express or implied, is
          -----------------
intended to confer upon any third party any rights, remedies, obligations or
liabilities.

                 [Remainder of page intentionally left blank]

                                       8
<PAGE>

     IN WITNESS WHEREOF, the undersigned have executed this Agreement under seal
as of the date provided below:

                                   THE COMPANY:

                                   SCIQUEST.COM, INC.

                                   By:    _____________________________________
                                   Name:  _____________________________________
                                   Title: _____________________________________

THE HOLDERS:

____________________________________
Mary T. Romac

____________________________________
Dale L. Young

____________________________________
Timothy M. Brady

                                       9

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