Document:

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                                                                    EXHIBIT 10.1

                     AMENDMENT NO. 1 TO CONSULTING AGREEMENT

      This Amendment No. 1 to the Consulting Agreement (the "Consulting
Agreement") dated as of November 1, 2001 between Samir Patel, M.D. (the
"Consultant") and Eyetech Pharmaceuticals, Inc., a Delaware corporation (the
"Company") with offices at 3 Time Square, 12th Floor, New York, NY 10036 is
effective as of January 1, 2004.

                                    RECITALS

      WHEREAS, the Consultant and the Company have entered into the Consulting
Agreement;

      WHEREAS, the Consulting Agreement expired on December 31, 2003;

      WHEREAS, the Company and the Consultant wish to extend the Consulting
Agreement and provide for Consultant's continued service to the Company through
September 30, 2004;

      NOW, THEREFORE, in consideration of the premises and agreement and
provisions hereinafter set forth, and for other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, the Consultant and
the Company agree as follows:

      1.    The first sentence of Section 3 is hereby deleted in its entirety
      and amended to read as follows: "The Consultant agrees to devote at least
      five (5) eight (8) hour days per week, for a total of forty (40) hours per
      week, to the provision of the Services" (the `Minimum Time Commitment")."

      2.    Section 4(a) is hereby deleted in its entirety and amended to read
      as follows: "This Agreement shall be deemed to be effective as of January
      1, 2004 and shall terminate on September 30, 2004 (the "Termination
      Date"). The term of this Agreement shall be referred to herein as the
      "Term."

      3.    The first sentence of Section 5(a) is hereby deleted in its entirety
      and amended to read as follows: "In consideration of the Consultant's
      performance hereunder, the Consultant shall be paid a monthly consultancy
      fee of $22,650. The Consultant shall be eligible for bonus from 0-25% of
      total consultancy fees earned from January 1, 2004 through September 30,
      2004. As this bonus is discretionary, any failure to provide bonus
      compensation under this section shall not give rise to any claim by
      Consultant for unpaid compensation."

      4.    Except as set forth above, all other provisions of the Consulting
      Agreement shall remain in full force and effect and are unmodified by this
      Amendment No. 1.

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      5.    This Amendment shall be governed in all respects, including as to
      validity, interpretation and effect, by the internal laws of the State of
      New York without giving effect to the conflict of laws and rules thereof.

      This Agreement may be executed in counterparts, each of which shall be
deemed an original and both of which shall together constitute one and the same
instrument.

      IN WITNESS WHEREOF, the parties have executed this amendment as of May 4,
2004.

                                   EYETECH PHARMACEUTICALS, INC.

                                   By: /s/ David Guyer, M.D.
                                       -----------------------------------
                                       Name:  David Guyer, M.D.
                                       Title: Chief Executive Officer

                                   CONSULTANT

                                   /s/ Samir Patel, M.D.
                                   ---------------------------------------
                                   Samir Patel, M.D.<PAGE>

EXHIBIT 10(a)

                                  May 10, 2004

Raybestos Products Company
1204 Darlington Avenue
Crawfordsville, IN 47933

Raytech Automotive Components Company
44600 Merrill Road
Sterling Heights, MI 48314

      RE:   WAIVER AND FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT

Gentlemen:

      Reference is made to the Loan and Security Agreement dated September 28,
2000 by and between Raybestos Products Company, Raytech Automotive Components
Company, and Automotive Composites Company (collectively the "Borrowers") and
Congress Financial Corporation (New England) (the "Lender"), as amended by that
certain Amendment to Loan and Security Agreement dated March 31, 2003, that
certain Second Amendment to Loan and Security Agreement dated August 12, 2003,
that certain Third Amendment to Loan and Security Agreement dated November 12,
2003, and that certain Fourth Amendment to Loan and Security Agreement dated
April 5, 2004 (as so amended, the "Loan Agreement"). All capitalized terms used
but not otherwise defined herein shall have the meanings given such terms in the
Loan Agreement. This agreement is hereby referred to as the "Fifth Amendment."

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May__, 2004
Page 2

      (1)   Background. Borrowers have requested that Lender waive a certain
existing Event of Default and Lender has agreed to do so. Additionally, Lender
has determined in its reasonable discretion that a certain Account of Borrowers
with General Motors Corporation and its affiliates (collectively, "GM," and the
"GM Account") is not an Eligible Account because of a potential right of setoff
(the "Specific Condition") that may arise pursuant to the terms of Borrowers
supply agreement with GM, as evidenced by certain quotations, award letters and
purchase orders (the "GM Supply Agreement"). Borrowers have also requested that
Lender agree to continue to make Revolving Loans to Borrowers under the Loan
Agreement, on the terms and conditions set forth herein and, in consideration
for Borrowers' agreement to provide a mortgage on certain of Borrowers' real
property in favor of Lender. Lender has agreed to the foregoing, subject to the
terms and conditions hereof.

      (2)   Waiver. Prior to March 27, 2004, Borrowers made Lender aware of
their inability to comply with Section 9.6(a) of the Loan Agreement as it
relates to delivery to Lender of Borrowers' 2003 Form 10-K filed with the
Securities and Exchange Commission and have requested a waiver of such
requirement for up to thirty days. Subject to the terms and conditions hereof,
Lender hereby waives for a period of thirty days commencing March 27, 2004, the
Borrowers' noncompliance with Section 9.6(a) of the Loan Agreement, solely as it
relates to Borrowers' failure to timely deliver to Lender its 2003 Form 10-K
filed with the Securities and Exchange Commission. Lender hereby acknowledges
that Borrowers have delivered to Lender the required 2003 Form 10-K within such
thirty day period. This waiver is limited to and enforceable only to the extent
specifically set forth herein and shall not be construed as a bar to or waiver
of any right, power and/or remedy which Lender would have on any future
occasion, whether similar in kind or otherwise.

      (3)   Mortgage. Within fifteen days of the date hereof, Borrowers shall
cause to be duly recorded a mortgage (the "Mortgage") in favor of Lender, in
form and substance satisfactory to Lender, for Borrowers' real property,
buildings and improvements (the "Property") located in the City of Sterling
Heights, Macomb County, Michigan (as more precisely identified in Exhibit A
hereto), so as to perfect in favor of Lender a valid first priority mortgage
lien on the Property, subject only to such interests as are described in that
certain Commitment for Title Insurance issued by the Chicago Title Insurance
Company regarding the Property (No. 50-510307) dated November 12, 2003 and
previously delivered to Lender's counsel. Lender shall discharge the Mortgage
upon and in connection with Borrowers' sale of the Property on arms' length
terms, provided that by such date Borrower and Lender have made arrangements
acceptable to Lender for the grant to Lender of substitute collateral. Upon
Lender's request, and if the same would not cause a default condition to arise
in connection with Borrowers' obligations to third parties, Borrowers shall also
cause to be recorded in favor of Lender a mortgage on its property in
Crawfordsville, Indiana to secure all amounts payable under the Loan Agreement.

      (4)   Eligible Accounts. Borrowers and Lender hereby agree that the GM
Account shall no longer be deemed an Eligible Account; provided, however, that
if Borrowers provide evidence satisfactory to Lender, in Lender's reasonable
discretion, that the Specific Condition is no longer applicable, then the GM
Account shall be deemed an Eligible Account solely to the

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May__, 2004
Page 3

extent otherwise set forth in the Loan Agreement (calculated as though the GM
Account were not subject to the Specific Condition). Notwithstanding the
foregoing, upon due recordation of the Mortgage, and subject to all of the other
limitations and conditions set forth in the Loan Agreement, Lender will make
Revolving Loans in an amount over and above the revolving loan limit (as
calculated without inclusion of the GM Account as an Eligible Account) under
Section 2.1(a) of the Loan Agreement, up to the lesser of:

            (a)   85% of the liquidation value of the Property, net of estimated
                  disposition costs and any accrued taxes or municipal charges,
                  all as reasonably determined by Lender;

            (b)   an amount equal to the amount of Revolving Loans that could be
                  borrowed against the GM Account if the GM Account were not
                  subject to the Specific Condition; and

            (c)   One Million Eight Hundred Seventy Thousand Dollars
                  ($1,870,000.00), or such lower amount as Lender may in its
                  reasonable discretion determine (the "Cap Amount"); provided,
                  however, that if Lender determines to reduce the Cap Amount
                  below One Million Eight Hundred Seventy Thousand Dollars
                  ($1,870,000.00), then Lender shall consent to Borrowers'
                  granting a mortgage interest in the Property that is senior to
                  the Mortgage to secure indebtedness of an amount equal to the
                  amount of Revolving Loans that could be borrowed against the
                  GM Account if the GM Account were not subject to the Specific
                  Condition, and upon Lender granting such consent, the Cap
                  Amount will be reduced to Zero Dollars ($0.00).

      (5)   Representations and Warranties. Each Borrower hereby represents,
warrants and covenants that (a) the representations and warranties of Borrowers
in the Financing Agreements, as modified by the updated and revised Schedules to
the Information Certificate attached to the Third Amendment, are and remain
accurate and complete in all material respects and (b) no Default or Event of
Default exists or has occurred and is continuing as of the date hereof (after
giving effect to this Letter Agreement).

      (6)   Enforceability of Obligations; Waiver. Each Borrower hereby agrees
that (i) the Financing Agreements are in full force and effect, and enforceable
against each Borrower in accordance with their respective terms, and (ii) each
Borrower has no offsets, claims or defenses to or in connection with the
Obligations, or the terms of the Financing Agreements, all of which offsets,
claims or defenses are hereby waived. Each Borrower hereby waives and
affirmatively agrees not to challenge or otherwise pursue any and all defenses,
affirmative defenses, counterclaims, claims, causes of action, setoffs or other
rights that it may have relating to the Obligations, the Financing Agreements,
or the Collateral therefore, including, but not limited to, any right to contest
the Existing Events of Default under the Financing Agreements or any other
Defaults or Events of Default, the liens and security interests in favor of
Lender, or the conduct of Lender in administering any such Obligations or
agreements.

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May__, 2004
Page 4

      (7)   Miscellaneous. Each Borrower hereby confirms that the Financing
Agreements remain in full force and effect without amendment or modification of
any kind, except for the amendments and modifications set forth herein. The
execution and delivery of this Fifth Amendment by Lender shall not be construed
as a waiver by Lender of any other term, covenant, condition or agreement under
the Financing Agreements. This Letter Agreement shall be deemed to be a
Financing Agreement and, together with the other Financing Agreements,
constitute the entire agreement between the parties with respect to the subject
matter hereof and supersedes all prior dealings, correspondence, conversations
or communications between the parties with respect to the subject matter hereof.
This Letter Agreement may be executed in counterparts and/or by facsimile, and
each such counterpart and facsimile shall be as valid as if an original
signature.

                  [Remainder of Page Intentionally Left Blank]

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   Signature Page to Waiver and Fifth Amendment to Loan and Security Agreement

  If you accept and agree to the foregoing please sign and return the enclosed
                         copy of this letter. Thank you.

                                                   Very truly yours,

                                           CONGRESS FINANCIAL CORPORATION
                                           (NEW ENGLAND)

                                           By:    /s/ Melissa A. Post
                                                  ------------------------------
                                           Name:  Melissa A. Post
                                           Title: Vice President

AGREED:

RAYBESTOS PRODUCTS COMPANY

By: John B. Devlin
    --------------------------
    Name: John B. Devlin
    Title: Treasurer

RAYTECH AUTOMOTIVE COMPONENTS COMPANY

By: John B. Devlin
    --------------------------
    Name: John B. Devlin
    Title: Treasurer

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                                    EXHIBIT A

                        DESCRIPTION OF MORTGAGED PREMISES

Section 4, town 2 north, range 12 east, commencing at the west 1/4 corner of
section 4; thence south 88 degrees 45 minutes 40 seconds east 1355.74 feet;
thence north 00 degrees 59 minutes 50 seconds east 2075.19 feet; thence south 89
degrees 29 minutes 30 seconds east 43.0 feet to the point of beginning; thence
north 00 degrees 59 minutes 50 seconds east 531.23 feet along the easterly right
of way line of Merrill Road; thence south 87 degrees 03 minutes 47 seconds east
565.0 feet; thence south 00 degrees 59 minutes 50 seconds west 358.0 feet;
thence south 87 degrees 03 minutes 47 seconds east 233.85 feet; thence south 00
degrees 56 minutes 24 seconds west 153.31 feet; thence north 88 degrees 28
minutes 30 seconds west 798.57 feet to the point of beginning.

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