Document:

Exhibit 10.12

                                ORTHODONTIX, INC.

                          STOCK OPTION AWARD AGREEMENT

      1.  Grant  of  Option.  Orthodontix,  Inc.,  a  Florida  corporation  (the
"Company"),  hereby grants to Jane Hsiao, Ph.D. (the "Grantee"),  an option (the
"Option")  to purchase  354,601  shares of the common  stock,  par value  $.0001
(which gives effect to the reverse stock split that went into effect on December
29, 2006) (the "Common  Stock"),  of the Company (the "Shares"),  at an exercise
price per share equal to $16.70 (the "Exercise  Price") subject to the terms and
provisions of this Stock Option Award  Agreement (the "Option  Agreement").  The
Company,  during  the term of the  Option,  will at all times  reserve  and keep
available  such  number  of  Shares  as  shall  be  sufficient  to  satisfy  the
requirements of the Option.

      2. Exercise of Option.

            (a) Right to Exercise.  The Option shall be  exercisable  during its
term in accordance with the following Vesting Schedule:

        Percentage of Stock              Vesting Date
        -------------------              ------------
        20%                              Sixth   months  after
                                         the Company's  Common
                                         Stock begins  trading
                                         on the American Stock
                                         Exchange

        20%                              on the  first  day of
                                         each six month period
                                         thereafter  such that
                                         all  shall  be  fully
                                         vested  on  the  30th
                                         month    after    the
                                         Company's      Common
                                         Stock begins  trading
                                         on the American Stock
                                         Exchange.

Notwithstanding  the  foregoing,  such  vesting  schedule  shall  cease  and all
unvested  options shall remain  unvested in the event Grantee  ceases to express
the  willingness to serve on the Board of Directors of the Company and no longer
serves on such  Board  and,  if not on the Board of  Directors  of the  Company,
ceases to provide and has not  provided  any services to the Company of the same
type that was provided while such Grantee was a member of the Board of Directors
("Continuous Service"). In no event shall the Company issue fractional Shares.

            (b) Acceleration of Award Upon Change in Control.

                  (i) Change in  Control.  Following  a Change in  Control,  the
Options  granted   hereunder   automatically   shall  become  fully  vested  and
exercisable, immediately upon the consummation of such Change in Control.

<PAGE>

                  (ii) Definition of "Change in Control". For purposes hereof, a
"Change in  Control"  means a change in  ownership  or  control  of the  Company
effected through either of the following transactions:

                          (A) the direct or indirect  acquisition  by any person
or related group of persons (other than an acquisition from or by the Company or
by a  Company-sponsored  employee  benefit plan or by a person that  directly or
indirectly  controls,  is controlled  by, or is under common  control with,  the
Company)  of  beneficial  ownership  (within  the  meaning  of Rule 13d-3 of the
Exchange  Act) of  securities  possessing  more than fifty  percent (50%) of the
total combined voting power of the Company's outstanding  securities pursuant to
a tender or exchange offer made directly to the Company's  stockholders  which a
majority of the  Continuing  Directors who are not  Affiliates or Associates (as
such terms are defined in Rule 12b-2 promulgated  under the Securities  Exchange
Act of 1934,  as  amended)  of the offeror do not  recommend  such  stockholders
accept, or

                          (B) a change in the  composition  of the Board  over a
period of twelve (12)  months or less such that a majority of the Board  members
(rounded up to the next whole number) ceases, by reason of one or more contested
elections  for  Board  membership,  to  be  comprised  of  individuals  who  are
Continuing Directors. For purposes hereof,  "Continuing Directors" means members
of the Board who either (i) have been Board members continuously for a period of
at least twelve (12) months or (ii) have been Board members for less than twelve
(12) months and were  elected or nominated  for election as Board  members by at
least a majority of the Board members  described in clause (i) who were still in
office at the time such election or nomination was approved by the Board.

                          (c)  Method  of   Exercise.   The   Option   shall  be
exercisable  by delivery  of an exercise  notice (a form of which is attached as
Exhibit A) which shall state the  election  to  exercise  the Option,  the whole
number of Shares in  respect of which the  Option is being  exercised,  and such
other  provisions  as set  forth in  Exhibit  A. The  exercise  notice  shall be
delivered  in person,  by certified  mail,  or by such other  reasonable  method
(including electronic transmission) accompanied by payment of the Exercise Price
and all  applicable  income and employment  taxes  required to be withheld.  The
Option  shall be deemed to be  exercised  upon  receipt  by the  Company of such
notice  accompanied by the Exercise Price and all applicable  withholding taxes,
which,  to the extent  selected,  shall be deemed to be  satisfied by use of the
broker-dealer  sale and remittance  procedure to pay the Exercise Price provided
in Section  3(d) below to the extent such  procedure is available to the Grantee
at the time of exercise  and such an exercise  would not violate any  applicable
law.

                          (d) Taxes.  No Shares will be delivered to the Grantee
or other  person  pursuant to the  exercise  of the Option  until the Grantee or
other person has made reasonable arrangements for the satisfaction of applicable
income  tax and  employment  tax  withholding  obligations,  including,  without
limitation, such other tax obligations of the Grantee incident to the receipt of
Shares.  Upon exercise of the Option,  the Company or the Grantee's employer may
offset or  withhold  (from  any  amount  owed by the  Company  or the  Grantee's
employer to the  Grantee) or collect  from the Grantee or other person an amount
sufficient to satisfy such tax withholding obligations.

                                       2
<PAGE>

      3. Method of Payment.  Payment of the Exercise  Price shall be made by any
of the  following,  or a  combination  thereof,  at the election of the Grantee;
provided,  however,  that  such  exercise  method  does  not  then  violate  any
applicable law:

            (a) cash;

            (b) check;

            (c)  surrender of Shares or delivery of a properly  executed form of
attestation of ownership of Shares which have a Fair Market Value on the date of
surrender or attestation equal to the aggregate  Exercise Price of the Shares as
to which the Option is being exercised;

            (d) payment  through a broker-dealer  sale and remittance  procedure
pursuant  to which the  Grantee  (i) shall  provide  written  instructions  to a
Company-designated brokerage firm to effect the immediate sale of some or all of
the  purchased  Shares and remit to the  Company  sufficient  funds to cover the
aggregate exercise price payable for the purchased Shares and (ii) shall provide
written  directives to the Company to deliver the certificates for the purchased
Shares   directly  to  such  brokerage  firm  in  order  to  complete  the  sale
transaction;

            (e) issuance of a note to the extent not  prohibited  by  applicable
law;

            (f) payment through a "net exercise" such that,  without the payment
of any funds,  the Grantee may exercise the Option and receive the net number of
Shares  equal to (i) the  number  of  Shares  as to which  the  Option  is being
exercised,  multiplied  by (ii) a fraction,  the  numerator of which is the Fair
Market Value per Share (on such date as is determined by the Administrator) less
the Exercise  Price,  and the denominator of which is such Fair Market Value per
Share (the  number of net  Shares to be  received  shall be rounded  down to the
nearest whole number of Shares); or

            (g) any combination of the foregoing methods of payment.

      4.  Restrictions  on Exercise.  The Option must be exercised no later than
the ten year anniversary of the date of grant (the "Expiration Date"). After the
Expiration  Date,  the Option shall be of no further force or effect and may not
be  exercised.  The Option may not be  exercised  if the  issuance of the Shares
subject to the Option upon such  exercise  would  constitute  a violation of any
Applicable Laws. If the exercise of the Option is prevented by the provisions of
this Section 4, the Option shall  remain  exercisable  until one (1) month after
the date the Grantee is notified by the Company that the Option is  exercisable,
but in any event no later than the Expiration Date.

      5.  Transferability of Option. The Option may be transferred by Grantee to
any person so long as Grantee  provides  notice of such  transfer to the Company
within five business days of completing such transfer. In addition,  Grantee may
designate one or more  beneficiaries  of the Grantee's Stock Option in the event
of the  Grantee's  death  on a  beneficiary  designation  form  provided  by the
officer,  director,  committee of the Board of Directors,  Board of Directors or
other  person  designated  to  administer  the  terms  of the  Company's  equity
incentive  compensation  (the  "Administrator").  Following  the  death  of  the
Grantee,  the Option may be  exercised  (a) by the person or persons  designated
under the deceased Grantee's beneficiary

                                       3
<PAGE>

designation or (b) in the absence of an effectively designated  beneficiary,  by
the Grantee's legal representative or by any person empowered to do so under the
deceased  Grantee's  will or  under  the then  applicable  laws of  descent  and
distribution.  The terms of the  Option  shall be  binding  upon the  executors,
administrators, heirs, successors and transferees of the Grantee.

      6.  Adjustment.  Subject to any required action by the stockholders of the
Company,  the number of Shares  covered by this  Option and the  Exercise  Price
shall be proportionately adjusted for (i) any increase or decrease in the number
of issued  shares of Common Stock  resulting  from a stock split,  reverse stock
split, stock dividend, combination or reclassification of the Shares, or similar
transaction  affecting  the Shares,  (ii) any other  increase or decrease in the
number  of  issued  shares  of  Common  Stock   effected   without   receipt  of
consideration  by the Company,  or (iii) any other  transaction  with respect to
Common  Stock  including  a  corporate  merger,  consolidation,  acquisition  of
property or stock,  separation  (including a spin-off or other  distribution  of
stock or property), reorganization, liquidation (whether partial or complete) or
any similar transaction.

      7. Tax  Consequences.  The Grantee may incur tax  liability as a result of
the Grantee's  purchase or disposition of the Shares. THE GRANTEE SHOULD CONSULT
A TAX ADVISER BEFORE EXERCISING THE OPTION OR DISPOSING OF THE SHARES.

      8. Entire Agreement:  Governing Law. This Option Agreement constitutes the
entire  agreement of the parties with respect to the subject  matter  hereof and
supersede in their entirety all prior undertakings and agreements of the Company
and the  Grantee  with  respect to the  subject  matter  hereof,  and may not be
modified adversely to the Grantee's interest except by means of a writing signed
by the Company and the  Grantee.  Nothing in this  Option  Agreement  (except as
expressly  provided therein) is intended to confer any rights or remedies on any
persons  other than the  parties.  This Option  Agreement  is to be construed in
accordance  with and  governed  by the  internal  laws of the  State of  Florida
without giving effect to any choice of law rule that would cause the application
of the laws of any  jurisdiction  other than the  internal  laws of the State of
Florida to the rights and duties of the  parties.  Should any  provision of this
Option  Agreement be determined to be illegal or  unenforceable,  such provision
shall be enforced to the fullest extent allowed by law and the other  provisions
shall nevertheless remain effective and shall remain enforceable.

      9.  Construction.  The captions used in this Option Agreement are inserted
for convenience and shall not be deemed a part of the Option for construction or
interpretation.  Except when  otherwise  indicated by the context,  the singular
shall include the plural and the plural shall  include the singular.  Use of the
term "or" is not intended to be exclusive,  unless the context clearly  requires
otherwise.

      10.  Venue and Waiver of Jury Trial.  The Company,  the  Grantee,  and the
Grantee's  assignees (the "parties") agree that any suit,  action, or proceeding
arising  out of or relating  to this  Option  Agreement  shall be brought in the
United  States  District  Court for the Southern  District of Florida (or should
such court lack  jurisdiction  to hear such  action,  suit or  proceeding,  in a
Florida  state court in the County of  Miami-Dade)  and that the  parties  shall
submit to the jurisdiction of such court. The parties  irrevocably waive, to the
fullest extent  permitted by law, any objection the party may have to the laying
of venue for any such suit, action or proceeding

                                       4
<PAGE>

brought in such court.  THE PARTIES ALSO EXPRESSLY  WAIVE ANY RIGHT THEY HAVE OR
MAY HAVE TO A JURY TRIAL OF ANY SUCH SUIT,  ACTION OR PROCEEDING.  If any one or
more  provisions  of this  Section  10 shall for any  reason be held  invalid or
unenforceable,  it is the specific  intent of the parties  that such  provisions
shall be modified to the minimum extent  necessary to make it or its application
valid and enforceable.

      11. Notices.  Any notice required or permitted hereunder shall be given in
writing  and shall be deemed  effectively  given upon  personal  delivery,  upon
deposit for  delivery by an  internationally  recognized  express  mail  courier
service or upon  deposit in the United  States  mail by  certified  mail (if the
parties are within the United States), with postage and fees prepaid,  addressed
to the other  party at its  address  as shown in these  instruments,  or to such
other  address as such party may  designate  in writing from time to time to the
other party.

      12. Definition of "Fair Market Value". As used herein, "Fair Market Value"
means, as of any date, the value of Common Stock determined as follows:

                  (i) If the Common  Stock is listed on one or more  established
stock  exchanges or national market systems,  including  without  limitation the
American Stock Exchange,  its Fair Market Value shall be the closing sales price
for such stock (or the closing bid, if no sales were  reported) as quoted on the
principal  exchange or system on which the Common Stock is listed (as determined
by the  Administrator)  on the date of  determination  (or, if no closing  sales
price or closing  bid was  reported  on that date,  as  applicable,  on the last
trading date such closing sales price or closing bid was reported),  as reported
in The Wall Street Journal;

                  (ii) If the Common Stock is  regularly  quoted on an automated
quotation  system  (including  the  OTC  Bulletin  Board)  or  by  a  recognized
securities  dealer,  its Fair Market Value shall be the closing  sales price for
such stock as quoted on such system or by such securities  dealer on the date of
determination,  but if selling prices are not reported, the Fair Market Value of
a share of Common  Stock  shall be the mean  between  the high bid and low asked
prices for the Common Stock on the date of determination  (or, if no such prices
were  reported on that date,  on the last date such prices  were  reported),  as
reported in The Wall Street  Journal or such other  source as the  Administrator
deems reliable; or

                  (iii) In the absence of an  established  market for the Common
Stock of the type  described  in (i) and  (ii),  above,  the Fair  Market  Value
thereof shall be reasonably  determined by the Board of Directors of the Company
in good faith.

                                END OF AGREEMENT

                                       5
<PAGE>

                                                    Accepted by:

                                                    ORTHODONTIX, INC.

                                                    By: /s/ David Aviezer
                                                        ------------------------

                                                    Title: CEO
                                                           ---------------------

                                                    Date: December 31, 2006

                                       6
<PAGE>

                                    EXHIBIT A

                                ORTHODONTIX, INC.

                                 EXERCISE NOTICE

Orthodontix, Inc.
2 Snunit Street
Science Park
POB 455
Carmiel, Israel 21000

Attention: Secretary

      1.  Exercise of Option.  Effective  as of today,  ______________,  ___ the
undersigned  (the "Grantee")  hereby elects to exercise the Grantee's  option to
purchase  ___________  shares of the Common Stock (the "Shares") of Orthodontix,
Inc. (the "Company") under and pursuant to the Stock Option Award Agreement (the
"Option  Agreement")  dated December 31, 2006.  Unless otherwise defined herein,
the terms defined in the Option  Agreement shall have the same defined  meanings
in this Exercise Notice.

      2.  Representations  of the  Grantee.  The Grantee  acknowledges  that the
Grantee has received,  read and  understood  the Option  Agreement and agrees to
abide by and be bound by their terms and conditions.

      3. Rights as  Stockholder.  Until the stock  certificate  evidencing  such
Shares is issued  (as  evidenced  by the  appropriate  entry on the books of the
Company or of a duly authorized transfer agent of the Company), no right to vote
or receive  dividends  or any other  rights as a  stockholder  shall  exist with
respect to the Shares,  notwithstanding  the exercise of the Option. The Company
shall issue (or cause to be issued) such stock  certificate  promptly  after the
Option is exercised.  No  adjustment  will be made for a dividend or other right
for which the record date is prior to the date the stock  certificate is issued,
except as provided in Section 6 of the Plan.

      4. Delivery of Payment.  The Grantee herewith  delivers to the Company the
full Exercise  Price for the Shares,  which,  to the extent  selected,  shall be
deemed to be satisfied by use of the broker-dealer sale and remittance procedure
to pay the Exercise Price provided in Section 3(d) of the Option Agreement.

      5. Tax Consultation.  The Grantee  understands that the Grantee may suffer
adverse tax consequences as a result of the Grantee's purchase or disposition of
the Shares.  The Grantee  represents that the Grantee has consulted with any tax
consultants  the Grantee  deems  advisable  in  connection  with the purchase or
disposition of the Shares and that the Grantee is not relying on the Company for
any tax advice.

      6. Taxes. The Grantee agrees to satisfy all applicable  foreign,  federal,
state and local income and employment tax  withholding  obligations and herewith
delivers  to the  Company  the  full  amount  of such  obligations  or has  made
arrangements acceptable to the Company to satisfy such obligations.

                                       1
<PAGE>

      7. Successors and Assigns.  The Grantee may assign any of its rights under
this Exercise Notice to single or multiple  assignees,  and this agreement shall
inure to the benefit of the successors and assigns of the Company. This Exercise
Notice  shall be binding  upon the  Company and its  executors,  administrators,
successors and assigns.

      8.  Construction.  The captions used in this Exercise  Notice are inserted
for  convenience  and  shall  not  be  deemed  a  part  of  this  agreement  for
construction or interpretation.  Except when otherwise indicated by the context,
the singular shall include the plural and the plural shall include the singular.
Use of the term "or" is not intended to be exclusive, unless the context clearly
requires otherwise.

      9. Governing Law; Severability. This Exercise Notice is to be construed in
accordance  with and  governed  by the  internal  laws of the  State of  Florida
without giving effect to any choice of law rule that would cause the application
of the laws of any  jurisdiction  other than the  internal  laws of the State of
Florida to the rights and duties of the  parties.  Should any  provision of this
Exercise Notice be determined by a court of law to be illegal or  unenforceable,
such  provision  shall be enforced to the fullest  extent allowed by law and the
other   provisions  shall   nevertheless   remain  effective  and  shall  remain
enforceable.

      10. Notices.  Any notice required or permitted hereunder shall be given in
writing  and shall be deemed  effectively  given upon  personal  delivery,  upon
deposit for  delivery by an  internationally  recognized  express  mail  courier
service or upon  deposit in the United  States  mail by  certified  mail (if the
parties are within the United States), with postage and fees prepaid,  addressed
to the other party at its address as shown below  beneath its  signature,  or to
such other  address as such party may  designate in writing from time to time to
the other party.

      11.  Further  Instruments.  The  parties  agree to  execute  such  further
instruments  and to take such further  action as may be reasonably  necessary to
carry out the purposes and intent of this agreement.

      12.  Entire  Agreement.  The Option  Agreement is  incorporated  herein by
reference and together with this Exercise Notice constitute the entire agreement
of the parties with respect to the subject  matter hereof and supersede in their
entirety all prior  undertakings  and  agreements of the Company and the Grantee
with respect to the subject matter hereof,  and may not be modified adversely to
the Grantee's  interest  except by means of a writing  signed by the Company and
the Grantee. Nothing in the Option Agreement and this Exercise Notice (except as
expressly  provided therein) is intended to confer any rights or remedies on any
persons other than the parties.

                                       2
<PAGE>

Submitted by:                                       Accepted by:

GRANTEE:                                            ORTHODONTIX, INC.

                                                    By:_________________________

_______________________________                     Title:______________________
(Signature)

Address:                                            Address:

_______________________________                     Orthodontix, Inc.
_______________________________                     2 Snunit Street
                                                    Science Park
                                                    POB 455
                                                    Carmiel, Israel 21000

                                       3Exhibit 10.13

                                ORTHODONTIX, INC.

                          STOCK OPTION AWARD AGREEMENT

      1.  Grant  of  Option.  Orthodontix,  Inc.,  a  Florida  corporation  (the
"Company"),  hereby  grants to Steven  Rubin  (the  "Grantee"),  an option  (the
"Option") to purchase  354,601 shares of the common stock, par value $.0001 (the
"Common Stock"),  of the Company (the "Shares"),  at an exercise price per share
equal to $16.70  (which gives  effect to the reverse  stock split that went into
effect on December 29,  2006) (the  "Exercise  Price")  subject to the terms and
provisions of this Stock Option Award  Agreement (the "Option  Agreement").  The
Company,  during  the term of the  Option,  will at all times  reserve  and keep
available  such  number  of  Shares  as  shall  be  sufficient  to  satisfy  the
requirements of the Option.

      2. Exercise of Option.

            (a) Right to Exercise.  The Option shall be  exercisable  during its
term in accordance with the following Vesting Schedule:

         Percentage of Stock             Vesting Date
         -------------------             ---------------------
         20%                             Sixth   months  after
                                         the Company's  Common
                                         Stock begins  trading
                                         on the American Stock
                                         Exchange

         20%                             on the  first  day of
                                         each six month period
                                         thereafter  such that
                                         all  shall  be  fully
                                         vested  on  the  30th
                                         month    after    the
                                         Company's      Common
                                         Stock begins  trading
                                         on the American Stock
                                         Exchange.

Notwithstanding  the  foregoing,  such  vesting  schedule  shall  cease  and all
unvested options shall remain unvested in the event Grantee ceases to provide to
the Company legal,  corporate and any other  consulting  services as required by
the Company,  it being agreed that Grantee  shall  provide such  services for at
least two working days per calendar month  ("Continuous  Service").  In no event
shall the Company issue fractional Shares.

            (b) Acceleration of Award Upon Change in Control.

                  (i) Change in  Control.  Following  a Change in  Control,  the
Options  granted   hereunder   automatically   shall  become  fully  vested  and
exercisable, immediately upon the consummation of such Change in Control.

                  (ii) Definition of "Change in Control". For purposes hereof, a
"Change in  Control"  means a change in  ownership  or  control  of the  Company
effected through either of the following transactions:

<PAGE>

                          (A) the direct or indirect  acquisition  by any person
or related group of persons (other than an acquisition from or by the Company or
by a  Company-sponsored  employee  benefit plan or by a person that  directly or
indirectly  controls,  is controlled  by, or is under common  control with,  the
Company)  of  beneficial  ownership  (within  the  meaning  of Rule 13d-3 of the
Exchange  Act) of  securities  possessing  more than fifty  percent (50%) of the
total combined voting power of the Company's outstanding  securities pursuant to
a tender or exchange offer made directly to the Company's  stockholders  which a
majority of the  Continuing  Directors who are not  Affiliates or Associates (as
such terms are defined in Rule 12b-2 promulgated  under the Securities  Exchange
Act of 1934,  as  amended)  of the offeror do not  recommend  such  stockholders
accept, or

                          (B) a change in the  composition  of the Board  over a
period of twelve (12)  months or less such that a majority of the Board  members
(rounded up to the next whole number) ceases, by reason of one or more contested
elections  for  Board  membership,  to  be  comprised  of  individuals  who  are
Continuing Directors. For purposes hereof,  "Continuing Directors" means members
of the Board who either (i) have been Board members continuously for a period of
at least twelve (12) months or (ii) have been Board members for less than twelve
(12) months and were  elected or nominated  for election as Board  members by at
least a majority of the Board members  described in clause (i) who were still in
office at the time such election or nomination was approved by the Board.

            (c) Method of Exercise.  The Option shall be exercisable by delivery
of an  exercise  notice (a form of which is  attached  as Exhibit A) which shall
state the election to exercise the Option, the whole number of Shares in respect
of which the Option is being  exercised,  and such other provisions as set forth
in Exhibit A. The exercise  notice  shall be  delivered in person,  by certified
mail, or by such other reasonable  method  (including  electronic  transmission)
accompanied  by  payment of the  Exercise  Price and all  applicable  income and
employment  taxes  required  to be  withheld.  The Option  shall be deemed to be
exercised upon receipt by the Company of such notice accompanied by the Exercise
Price and all applicable withholding taxes, which, to the extent selected, shall
be  deemed  to be  satisfied  by use of the  broker-dealer  sale and  remittance
procedure to pay the Exercise Price provided in Section 3(d) below to the extent
such  procedure  is available to the Grantee at the time of exercise and such an
exercise would not violate any applicable law.

            (d)  Taxes.  No Shares  will be  delivered  to the  Grantee or other
person  pursuant to the exercise of the Option until the Grantee or other person
has made reasonable  arrangements for the satisfaction of applicable  income tax
and employment tax withholding obligations,  including, without limitation, such
other tax  obligations  of the Grantee  incident to the receipt of Shares.  Upon
exercise of the  Option,  the Company or the  Grantee's  employer  may offset or
withhold  (from any amount owed by the Company or the Grantee's  employer to the
Grantee) or collect  from the Grantee or other  person an amount  sufficient  to
satisfy such tax withholding obligations.

      3. Method of Payment.  Payment of the Exercise  Price shall be made by any
of the  following,  or a  combination  thereof,  at the election of the Grantee;
provided,  however,  that  such  exercise  method  does  not  then  violate  any
applicable law:

                                       2
<PAGE>

            (a) cash;

            (b) check;

            (c)  surrender of Shares or delivery of a properly  executed form of
attestation of ownership of Shares which have a Fair Market Value on the date of
surrender or attestation equal to the aggregate  Exercise Price of the Shares as
to which the Option is being exercised;

            (d) payment  through a broker-dealer  sale and remittance  procedure
pursuant  to which the  Grantee  (i) shall  provide  written  instructions  to a
Company-designated brokerage firm to effect the immediate sale of some or all of
the  purchased  Shares and remit to the  Company  sufficient  funds to cover the
aggregate exercise price payable for the purchased Shares and (ii) shall provide
written  directives to the Company to deliver the certificates for the purchased
Shares   directly  to  such  brokerage  firm  in  order  to  complete  the  sale
transaction;

            (e) issuance of a note to the extent not  prohibited  by  applicable
law;

            (f) payment through a "net exercise" such that,  without the payment
of any funds,  the Grantee may exercise the Option and receive the net number of
Shares  equal to (i) the  number  of  Shares  as to which  the  Option  is being
exercised,  multiplied  by (ii) a fraction,  the  numerator of which is the Fair
Market Value per Share (on such date as is determined by the Administrator) less
the Exercise  Price,  and the denominator of which is such Fair Market Value per
Share (the  number of net  Shares to be  received  shall be rounded  down to the
nearest whole number of Shares); or

            (g) any combination of the foregoing methods of payment.

      4.  Restrictions  on Exercise.  The Option must be exercised no later than
the ten year anniversary of the date of grant (the "Expiration Date"). After the
Expiration  Date,  the Option shall be of no further force or effect and may not
be  exercised.  The Option may not be  exercised  if the  issuance of the Shares
subject to the Option upon such  exercise  would  constitute  a violation of any
Applicable Laws. If the exercise of the Option is prevented by the provisions of
this Section 4, the Option shall  remain  exercisable  until one (1) month after
the date the Grantee is notified by the Company that the Option is  exercisable,
but in any event no later than the Expiration Date.

      5.  Transferability of Option. The Option may be transferred by Grantee to
any person so long as Grantee  provides  notice of such  transfer to the Company
within five business days of completing such transfer. In addition,  Grantee may
designate one or more  beneficiaries  of the Grantee's Stock Option in the event
of the  Grantee's  death  on a  beneficiary  designation  form  provided  by the
officer,  director,  committee of the Board of Directors,  Board of Directors or
other  person  designated  to  administer  the  terms  of the  Company's  equity
incentive  compensation  (the  "Administrator").  Following  the  death  of  the
Grantee,  the Option may be  exercised  (a) by the person or persons  designated
under the deceased Grantee's beneficiary designation or (b) in the absence of an
effectively designated beneficiary,  by the Grantee's legal representative or by
any person  empowered  to do so under the deceased  Grantee's  will or under the
then applicable laws of descent and distribution.  The terms of the Option shall
be binding upon the executors, administrators, heirs, successors and transferees
of the Grantee.

                                       3
<PAGE>

      6.  Adjustment.  Subject to any required action by the stockholders of the
Company,  the number of Shares  covered by this  Option and the  Exercise  Price
shall be proportionately adjusted for (i) any increase or decrease in the number
of issued  shares of Common Stock  resulting  from a stock split,  reverse stock
split, stock dividend, combination or reclassification of the Shares, or similar
transaction  affecting  the Shares,  (ii) any other  increase or decrease in the
number  of  issued  shares  of  Common  Stock   effected   without   receipt  of
consideration  by the Company,  or (iii) any other  transaction  with respect to
Common  Stock  including  a  corporate  merger,  consolidation,  acquisition  of
property or stock,  separation  (including a spin-off or other  distribution  of
stock or property), reorganization, liquidation (whether partial or complete) or
any similar transaction.

      7. Tax  Consequences.  The Grantee may incur tax  liability as a result of
the Grantee's  purchase or disposition of the Shares. THE GRANTEE SHOULD CONSULT
A TAX ADVISER BEFORE EXERCISING THE OPTION OR DISPOSING OF THE SHARES.

      8. Entire Agreement:  Governing Law. This Option Agreement constitutes the
entire  agreement of the parties with respect to the subject  matter  hereof and
supersede in their entirety all prior undertakings and agreements of the Company
and the  Grantee  with  respect to the  subject  matter  hereof,  and may not be
modified adversely to the Grantee's interest except by means of a writing signed
by the Company and the  Grantee.  Nothing in this  Option  Agreement  (except as
expressly  provided therein) is intended to confer any rights or remedies on any
persons  other than the  parties.  This Option  Agreement  is to be construed in
accordance  with and  governed  by the  internal  laws of the  State of  Florida
without giving effect to any choice of law rule that would cause the application
of the laws of any  jurisdiction  other than the  internal  laws of the State of
Florida to the rights and duties of the  parties.  Should any  provision of this
Option  Agreement be determined to be illegal or  unenforceable,  such provision
shall be enforced to the fullest extent allowed by law and the other  provisions
shall nevertheless remain effective and shall remain enforceable.

      9.  Construction.  The captions used in this Option Agreement are inserted
for convenience and shall not be deemed a part of the Option for construction or
interpretation.  Except when  otherwise  indicated by the context,  the singular
shall include the plural and the plural shall  include the singular.  Use of the
term "or" is not intended to be exclusive,  unless the context clearly  requires
otherwise.

      10.  Venue and Waiver of Jury Trial.  The Company,  the  Grantee,  and the
Grantee's  assignees (the "parties") agree that any suit,  action, or proceeding
arising  out of or relating  to this  Option  Agreement  shall be brought in the
United  States  District  Court for the Southern  District of Florida (or should
such court lack  jurisdiction  to hear such  action,  suit or  proceeding,  in a
Florida  state court in the County of  Miami-Dade)  and that the  parties  shall
submit to the jurisdiction of such court. The parties  irrevocably waive, to the
fullest extent  permitted by law, any objection the party may have to the laying
of venue for any such suit,  action or  proceeding  brought in such  court.  THE
PARTIES ALSO EXPRESSLY  WAIVE ANY RIGHT THEY HAVE OR MAY HAVE TO A JURY TRIAL OF
ANY SUCH  SUIT,  ACTION OR  PROCEEDING.  If any one or more  provisions  of this
Section 10 shall for any  reason be held  invalid  or  unenforceable,  it is the
specific  intent of the parties  that such  provisions  shall be modified to the
minimum extent necessary to make it or its application valid and enforceable.

                                       4
<PAGE>

      11. Notices.  Any notice required or permitted hereunder shall be given in
writing  and shall be deemed  effectively  given upon  personal  delivery,  upon
deposit for  delivery by an  internationally  recognized  express  mail  courier
service or upon  deposit in the United  States  mail by  certified  mail (if the
parties are within the United States), with postage and fees prepaid,  addressed
to the other  party at its  address  as shown in these  instruments,  or to such
other  address as such party may  designate  in writing from time to time to the
other party.

      12. Definition of "Fair Market Value". As used herein, "Fair Market Value"
means, as of any date, the value of Common Stock determined as follows:

                  (i) If the Common  Stock is listed on one or more  established
stock  exchanges or national market systems,  including  without  limitation the
American Stock Exchange,  its Fair Market Value shall be the closing sales price
for such stock (or the closing bid, if no sales were  reported) as quoted on the
principal  exchange or system on which the Common Stock is listed (as determined
by the  Administrator)  on the date of  determination  (or, if no closing  sales
price or closing  bid was  reported  on that date,  as  applicable,  on the last
trading date such closing sales price or closing bid was reported),  as reported
in The Wall Street Journal;

                  (ii) If the Common Stock is  regularly  quoted on an automated
quotation  system  (including  the  OTC  Bulletin  Board)  or  by  a  recognized
securities  dealer,  its Fair Market Value shall be the closing  sales price for
such stock as quoted on such system or by such securities  dealer on the date of
determination,  but if selling prices are not reported, the Fair Market Value of
a share of Common  Stock  shall be the mean  between  the high bid and low asked
prices for the Common Stock on the date of determination  (or, if no such prices
were  reported on that date,  on the last date such prices  were  reported),  as
reported in The Wall Street  Journal or such other  source as the  Administrator
deems reliable; or

                  (iii) In the absence of an  established  market for the Common
Stock of the type  described  in (i) and  (ii),  above,  the Fair  Market  Value
thereof shall be reasonably  determined by the Board of Directors of the Company
in good faith.

                                                    ORTHODONTIX, INC.

                                                    By: /s/ David Aviezer
                                                        ------------------------

                                                    Title: CEO
                                                           ---------------------

                                                    Date: December 31, 2006

                                       5
<PAGE>

                                    EXHIBIT A

                                ORTHODONTIX, INC.

                                 EXERCISE NOTICE

Orthodontix, Inc.
2 Snunit Street
Science Park
POB 455
Carmiel, Israel 21000

Attention: Secretary

      1.  Exercise of Option.  Effective  as of today,  ______________,  ___ the
undersigned  (the "Grantee")  hereby elects to exercise the Grantee's  option to
purchase  ___________  shares of the Common Stock (the "Shares") of Orthodontix,
Inc. (the "Company") under and pursuant to the Stock Option Award Agreement (the
"Option  Agreement")  dated December 31, 2006.  Unless otherwise defined herein,
the terms defined in the Option  Agreement shall have the same defined  meanings
in this Exercise Notice.

      2.  Representations  of the  Grantee.  The Grantee  acknowledges  that the
Grantee has received,  read and  understood  the Option  Agreement and agrees to
abide by and be bound by their terms and conditions.

      3. Rights as  Stockholder.  Until the stock  certificate  evidencing  such
Shares is issued  (as  evidenced  by the  appropriate  entry on the books of the
Company or of a duly authorized transfer agent of the Company), no right to vote
or receive  dividends  or any other  rights as a  stockholder  shall  exist with
respect to the Shares,  notwithstanding  the exercise of the Option. The Company
shall issue (or cause to be issued) such stock  certificate  promptly  after the
Option is exercised.  No  adjustment  will be made for a dividend or other right
for which the record date is prior to the date the stock  certificate is issued,
except as provided in Section 6 of the Plan.

      4. Delivery of Payment.  The Grantee herewith  delivers to the Company the
full Exercise  Price for the Shares,  which,  to the extent  selected,  shall be
deemed to be satisfied by use of the broker-dealer sale and remittance procedure
to pay the Exercise Price provided in Section 3(d) of the Option Agreement.

      5. Tax Consultation.  The Grantee  understands that the Grantee may suffer
adverse tax consequences as a result of the Grantee's purchase or disposition of
the Shares.  The Grantee  represents that the Grantee has consulted with any tax
consultants  the Grantee  deems  advisable  in  connection  with the purchase or
disposition of the Shares and that the Grantee is not relying on the Company for
any tax advice.

      6. Taxes. The Grantee agrees to satisfy all applicable  foreign,  federal,
state and local income and employment tax  withholding  obligations and herewith
delivers  to the  Company  the  full  amount  of such  obligations  or has  made
arrangements acceptable to the Company to satisfy such obligations.

                                       1
<PAGE>

      7. Successors and Assigns.  The Grantee may assign any of its rights under
this Exercise Notice to single or multiple  assignees,  and this agreement shall
inure to the benefit of the successors and assigns of the Company. This Exercise
Notice  shall be binding  upon the  Company and its  executors,  administrators,
successors and assigns.

      8.  Construction.  The captions used in this Exercise  Notice are inserted
for  convenience  and  shall  not  be  deemed  a  part  of  this  agreement  for
construction or interpretation.  Except when otherwise indicated by the context,
the singular shall include the plural and the plural shall include the singular.
Use of the term "or" is not intended to be exclusive, unless the context clearly
requires otherwise.

      9. Governing Law; Severability. This Exercise Notice is to be construed in
accordance  with and  governed  by the  internal  laws of the  State of  Florida
without giving effect to any choice of law rule that would cause the application
of the laws of any  jurisdiction  other than the  internal  laws of the State of
Florida to the rights and duties of the  parties.  Should any  provision of this
Exercise Notice be determined by a court of law to be illegal or  unenforceable,
such  provision  shall be enforced to the fullest  extent allowed by law and the
other   provisions  shall   nevertheless   remain  effective  and  shall  remain
enforceable.

      10. Notices.  Any notice required or permitted hereunder shall be given in
writing  and shall be deemed  effectively  given upon  personal  delivery,  upon
deposit for  delivery by an  internationally  recognized  express  mail  courier
service or upon  deposit in the United  States  mail by  certified  mail (if the
parties are within the United States), with postage and fees prepaid,  addressed
to the other party at its address as shown below  beneath its  signature,  or to
such other  address as such party may  designate in writing from time to time to
the other party.

      11.  Further  Instruments.  The  parties  agree to  execute  such  further
instruments  and to take such further  action as may be reasonably  necessary to
carry out the purposes and intent of this agreement.

      12.  Entire  Agreement.  The Option  Agreement is  incorporated  herein by
reference and together with this Exercise Notice constitute the entire agreement
of the parties with respect to the subject  matter hereof and supersede in their
entirety all prior  undertakings  and  agreements of the Company and the Grantee
with respect to the subject matter hereof,  and may not be modified adversely to
the Grantee's  interest  except by means of a writing  signed by the Company and
the Grantee. Nothing in the Option Agreement and this Exercise Notice (except as
expressly  provided therein) is intended to confer any rights or remedies on any
persons other than the parties.

                                       2
<PAGE>

Submitted by:                                       Accepted by:

GRANTEE:                                            ORTHODONTIX, INC.

                                                    By:_________________________

__________________________________                  Title:______________________
(Signature)

Address:                                            Address:

__________________________________                  Orthodontix, Inc.
__________________________________                  2 Snunit Street
                                                    Science Park
                                                    POB 455
                                                    Carmiel, Israel 21000

                                       3

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