Document:

Exhibit 4.15

 

EXECUTION VERSION

 

ABBVIE INC.

 

SUPPLEMENTAL INDENTURE NO. 9

 

€547,703,000 Floating
Rate Notes due 2020

€539,018,000 0.500%
Senior Notes due 2021

€433,228,000 1.500%
Senior Notes due 2023

€603,389,000 1.250%
Senior Notes due 2024

€427,893,000 2.625%
Senior Notes due 2028

€513,538,000 2.125%
Senior Notes due 2029

 

THIS SUPPLEMENTAL INDENTURE NO. 9, dated
as of May 14, 2020 (the “Supplemental Indenture”), among ABBVIE INC., a Delaware corporation (the “Company”),
U.S. BANK NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”), ELAVON FINANCIAL
SERVICES DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. BANK NATIONAL ASSOCIATION, as transfer
agent and registrar (the “Transfer Agent” and/or “Security Registrar”).

 

RECITALS OF THE COMPANY:

 

WHEREAS, the Company has heretofore executed
and delivered to the Trustee an Indenture, dated as of November 8, 2012 (as heretofore supplemented or amended, the “Indenture”),
providing for the issuance from time to time of one or more series of Securities (as defined in the Indenture);

 

WHEREAS, the Company has entered into a
definitive transaction agreement, dated as of June 25, 2019, by and among the Company, Allergan plc, an Irish public limited company
(“Allergan”), and Venice Subsidiary LLC, a wholly owned subsidiary of the Company (“Acquiror Sub”),
as amended from time to time, which provides, among other things, that on the terms and subject to conditions set forth therein,
Acquiror Sub will acquire Allergan, with Allergan surviving as a wholly-owned subsidiary of the Company (the “Acquisition”);

 

WHEREAS, in connection with the Acquisition,
the Company offered to exchange (the “Exchange Offers”) any and all outstanding notes of certain series issued
by Allergan Finance, LLC, Allergan, Inc., Allergan Sales, LLC and Allergan Funding SCS (the “Allergan Notes”)
for notes issued by the Company pursuant to an Offering Memorandum and Consent Solicitation Statement, dated as of October 25,
2019 (as amended, the “Offering Memorandum and Consent Solicitation Statement”);

 

WHEREAS, the Company has duly determined
to appoint the Paying Agent as the paying agent and the Transfer Agent and Security Registrar as the transfer agent and registrar,
each under the Agency Agreement, dated as of the date hereof (the “Agency Agreement”), and the Paying Agent
and the Transfer Agent and Security Registrar are willing to accept such appointment with respect to the Notes;

 

WHEREAS, Article Nine of the Indenture
provides for various matters with respect to any series of Securities issued under the Indenture to be established in an indenture
supplemental to the Indenture;

 

     

     

    

 

WHEREAS, Section 9.1(7) of the
Indenture provides that the Company and the Trustee may enter into an indenture supplemental to the Indenture to establish the
form or terms of Securities of any series as permitted by Sections 2.1 and 3.1 of the Indenture;

 

WHEREAS, Section 9.1 of the Indenture provides
that the Company and the Trustee may modify certain terms of the Indenture and provide certain additional provisions with respect
to any series of Securities to be issued under the Indenture; and

 

WHEREAS, all the conditions and requirements
necessary to make this Supplemental Indenture, when duly executed and delivered, a valid and binding agreement in accordance with
its terms and for the purposes herein expressed, have been performed and fulfilled.

 

NOW THEREFORE, THIS SUPPLEMENTAL INDENTURE
WITNESSETH:

 

For and in consideration of the premises
and the issuance of the series of Securities provided for herein, the Company and the Trustee mutually covenant and agree for the
equal and proportionate benefit of the respective Holders of the Securities of each such series as follows:

 

Article 1

RELATION TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION

 

Section 1.1.          
Relation to Indenture.  This Supplemental Indenture constitutes an integral part of the Indenture.

 

Section 1.2.          
Relation to Agency Agreement. The terms of this Supplemental Indenture are subject to the
terms of the Agency Agreement, which shall be deemed incorporated herein. In the event of an inconsistency between the terms of
the Indenture, this Supplemental Indenture and the Agency Agreement, the terms of the Agency Agreement shall prevail, except that
the rights, benefits, protections, indemnities and immunities of the Trustee shall be governed by the Indenture and this Supplemental
Indenture.

 

Section 1.3.          
Definitions.  For all purposes of this Supplemental Indenture, the following terms shall have the respective meanings
set forth in this Section.

 

“2021 Notes”
means the 0.500% Senior Notes due 2021.

 

“2023 Notes”
means the 1.500% Senior Notes due 2023.

 

“2024 Notes”
means the 1.250% Senior Notes due 2024.

 

“2028 Notes”
means the 2.625% Senior Notes due 2028.

 

“2029 Notes”
means the 2.125% Senior Notes due 2029.

 

“Applicable Procedures”
means, with respect to any transfer or transaction involving a Regulation S Global Note or beneficial interest therein, the
rules and procedures of Euroclear, Clearstream and their respective nominees and successors, acting through itself or the Common
Depositary, in each case to the extent applicable to such transaction and as in effect from time to time.

 

    	 	2	 

     

    

 

“Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the TARGET2 System (as defined
below), or any successor thereto, operates.

 

“Clearstream”
means Clearstream Banking S.A.

 

“Common Depositary”
means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be Elavon Financial Services
DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the maturity of the Notes, or if the Independent Investment Bank in its discretion determines that
such similar bond is not in issue, such other German government bond as the Independent Investment Bank may, with the advice of
three brokers of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining
the Comparable Government Bond Rate.

 

“Comparable
Government Bond Rate” means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005
being rounded upwards), on the third Business Day prior to the date fixed for redemption, of the Comparable Government Bond on
the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business
Day as determined by an Independent Investment Bank.

 

“Corporate
Trust Office of the Paying Agent” means, initially, the office of Elavon Financial Services DAC, U.K. Branch located
at 125 Old Broad Street, London, EC2N 1AR, United Kingdom.

 

“Corporate
Trust Office of the Registrar and Transfer Agent” means, initially, the office of U.S. Bank National Association located
at 190 South LaSalle Street, 10th Floor Chicago, IL 60603.

 

“Dealer Managers”
means Morgan Stanley & Co. LLC, BofA Securities, Inc., Citigroup Global Markets Inc., BNP Paribas Securities Corp., HSBC Securities
(USA) Inc., Mizuho Securities USA LLC and Wells Fargo Securities, LLC.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend and in a customary form agreed by the Company, the Trustee and
the Paying Agent and security printed in accordance with any applicable legal and stock exchange requirements.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

 

    	 	3	 

     

    

 

“Euroclear” means Euroclear
Bank SA/NV, as operator of the Euroclear System.

 

“Exchange Notes” has
the meaning specified in the Registration Rights Agreement.

 

“Fixed Rate Notes” means
the 2021 Notes, the 2023 Notes, the 2024 Notes, the 2028 Notes and the 2029 Notes.

 

“Floating Rate Notes”
means the Floating Rate Notes due 2020.

 

“Global Notes Legend”
means the legend set forth in Exhibits A1 through A6 to this Supplemental Indenture.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

“Initial Notes” means
the Notes issued pursuant to this Supplemental Indenture on the date hereof.

 

“Notes” means, collectively,
the Floating Rate Notes and the Fixed Rate Notes.

 

“Par Call Date” means
(i) with respect to the 2021 Notes, May 1, 2021, (ii) with respect to the 2023 Notes, October 15, 2023, (iii) with respect to the
2024 Notes, March 1, 2024, (iv) with respect to the 2028 Notes, August 15, 2028 and (v) with respect to the 2029 Notes, March 1,
2029.

 

“QIB” means qualified
institutional buyer as specified in Rule 144A promulgated under the Securities Act.

 

“Registered Exchange Offer”
means the offer by the Company, pursuant to the Registration Rights Agreement, to certain Holders of Initial Notes, to issue and
deliver to such Holders, in exchange for their Initial Notes, a like aggregate principal amount of Exchange Notes in an exchange
registered under the Securities Act.

 

“Registration Rights Agreement”
means the Registration Rights Agreement, dated as of May 14, 2020, by and among the Company and the Dealer Managers.

 

“Regulation S” means
Regulation S promulgated under the Securities Act.

 

“Regulation S Notes”
means all Notes offered and issued pursuant to the Exchange Offers to holders of Allergan Notes in an offshore transaction in reliance
on Regulation S.

 

“Restricted Notes Legend”
means the legend set forth in Section 2.7(e)(i) hereof.

 

“Restricted Period” means,
with respect to any Notes, the period that is 40 consecutive days beginning on and including the later of (i) the day
on which such Notes are first offered to Persons other than distributors (as defined in Regulation S under the Securities
Act) in reliance on Regulation S and (ii) the date of original issuance with respect to such Notes.

 

“Rule 144” means
Rule 144 promulgated under the Securities Act.

 

    	 	4	 

     

    

 

“Rule 144A” means
Rule 144A promulgated under the Securities Act.

 

“Rule 144A Notes” means
all Notes offered and issued pursuant to the Exchange Offers to holders of Allergan Notes reasonably believed to be QIBs in reliance
on Rule 144A.

 

“Securities Act” means
the U.S. Securities Act of 1933, as amended.

 

“Transfer Restricted Note”
means any Note that bears or is required to bear a Restricted Notes Legend.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Section 1.4.          
Rules of Construction.  For all purposes of this Supplemental Indenture:

 

(a)              
capitalized terms used herein without definition shall have the meanings specified in the Indenture;

 

(b)              
all references herein to Articles and Sections, unless otherwise specified, refer to the corresponding Articles and Sections
of this Supplemental Indenture;

 

(c)              
the terms “herein,” “hereof,” “hereunder” and other words of similar import refer to
this Supplemental Indenture; and

 

(d)              
in the event of a conflict with the definition of terms in the Indenture, the definitions in this Supplemental Indenture
shall control.

 

Section 1.5.          
References. References to the Security Register in
the Indenture will be deemed to refer to the register of Holders of the Notes as prescribed by this Supplemental Indenture, and
the provisions of the Notes and references to the Security Registrar in the Indenture will be deemed to refer to the Registrar
as defined in the Agency Agreement and the Notes.

 

Article 2

THE SECURITIES

 

Section 2.1.          
Title of the Notes.  There shall be (i) a series of Securities designated the Floating Rate Notes due 2020, (ii)
a series of Securities designated the 0.500% Senior Notes due 2021, (iii) a series of Securities designated the 1.500% Senior Notes
due 2023, (iv) a series of Securities designated the 1.250% Senior Notes due 2024, (v) a series of Securities designated the
2.625% Senior Notes due 2028 and (vi) a series of Securities designated the 2.125% Senior Notes due 2029.

 

Section 2.2.          
Initial Principal Amount. The Floating Rate Notes will be initially issued in an aggregate
principal amount of €547,703,000. The 2021 Notes will be initially issued in an aggregate principal amount of €539,018,000.
The 2023 Notes will be initially issued in an aggregate principal amount of €433,228,000. The 2024 Notes will be initially
issued in an aggregate principal amount of €603,389,000. The 2028 Notes will be initially issued in an aggregate principal
amount of €427,893,000. The 2029 Notes will be initially issued in an aggregate principal amount of €513,538,000. 

 

    	 	5	 

     

    

 

Section 2.3.          
Interest on the Floating Rate Notes. Interest on the Floating Rate Notes will accrue from
(and including) the most recent date on which interest has been paid or duly provided for by Allergan Funding SCS on the Allergan
2020 Floating Rate Notes (as defined in the Offering Memorandum and Consent Solicitation Statement) that were accepted in the Exchange
Offers. Interest on the Floating Rate Notes will be payable on the applicable interest payment dates set forth in Exhibit A1 attached
hereto. The first interest payment date on the Floating Rate Notes is set forth in Exhibit A1 attached hereto. Interest will be
payable to the Persons in whose names the Floating Rate Notes are registered at the close of business on the 15th calendar day
immediately preceding the interest payment date (whether or not a Business Day) (such day, the “Floating Rate Notes Record
Date”). However, interest paid on the maturity date will be payable to the Person to whom the principal will be payable.
The amount of interest for each day that the Floating Rate Notes are outstanding (the “Daily Interest Amount”)
will be calculated by dividing the interest rate in effect for such day by 360 and multiplying the result by the principal amount
of the Floating Rate Notes outstanding on such day. The amount of interest to be paid on the Floating Rate Notes for each interest
period will be calculated by adding such Daily Interest Amounts for each day in such interest period.

 

Section 2.4.          
Interest on the Fixed Rate Notes. Interest on each series of Fixed Rate Notes will accrue
from (and including) the most recent date on which interest has been paid or duly provided for by Allergan Funding SCS on the corresponding
series of Allergan Euro Notes (as defined in the Offering Memorandum and Consent Solicitation Statement) that were accepted in
the Exchange Offers. Interest on each series of Fixed Rate Notes will be payable on the applicable interest payment dates set forth
in the corresponding Exhibits A2-A6 attached hereto. The first interest payment date on each series of the Fixed Rate Notes is
set forth in the corresponding Exhibits A2-A6 attached hereto. Interest will be payable to the Persons in whose names the Fixed
Rate Notes are registered at the close of business on the date that is (i) in the case of Fixed Rate Notes represented by a Global
Note, the clearing system business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments
in euro) immediately prior to the relevant interest payment date and (ii) in all other cases, 15 calendar days prior to the relevant
interest payment date (whether or not a Business Day) (such day, the “Fixed Rate Notes Record Date” and, together
with the Floating Rate Notes Record Date, the “Record Date”). Interest on the Fixed Rate Notes shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Fixed Rate Notes, but excluding the next following interest payment date. This
payment convention is referred to as ACTUAL/ACTUAL (ICMA) as defined in the rulebook of the International Capital Market Association.

 

    	 	6	 

     

    

 

Section 2.5.          
Issuance In Euro. All payments of principal of, and premium, if any, and interest on, the
Notes, including payments made upon any redemption of the Notes, shall be payable in euro. If the Company is unable to obtain euro
in amounts sufficient to make a required payment under the Notes due to the imposition of exchange controls or other circumstances
beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro is no longer being
used by the then member states of the European Monetary Union that have adopted the euro as their currency or for the settlement
of transactions by public institutions or within the international banking community, then all payments in respect of the Notes
shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such circumstances, the amount payable
on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal Reserve Board as of the close
of business on the second business day prior to the relevant payment date or, in the event the U.S. Federal Reserve Board has not
mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate available on or prior to the
second business day prior to the relevant payment date as determined by the Company in its sole discretion. Any payment in respect
of the Notes so made in U.S. Dollar shall not constitute an Event of Default under the Notes or the Indenture. Neither the Trustee
nor the Paying Agent shall have any responsibility for any calculation or conversion in connection with the foregoing. 

 

Section 2.6.          
Form and Dating.

 

(a)           
General.  The Notes shall initially be issued in the form of one or more Global
Notes in fully registered, book-entry form, duly executed by the Company and authenticated by the Trustee, which shall be deposited
with the Common Depositary and shall be registered in the name of USB Nominees (UK) Limited, as nominee of Elavon Financial Services
DAC, as common depositary for Euroclear and Clearstream. The Notes shall be substantially in the forms set forth in the corresponding
Exhibits A1-A6 attached hereto (other than, (i) with respect to any additional Notes of any series of the Notes, changes related
to issue date, issue price and first interest payment date of such additional Notes, and (ii) with respect to any Exchange Notes
of any series of the Notes, changes related to legends, transfer restrictions, CUSIP/ISIN numbers and other changes customary for
registered notes). The Notes may have notations, legends or endorsements required by law, stock exchange rule or usage. Each
Note shall be dated the date of its authentication. The Notes shall be issued in fully registered form only in denominations of
 €100,000 and integral multiples of €1,000 in excess thereof. The Notes of each series and any additional Notes of such
series subsequently issued under the Indenture, together with any Exchange Notes issued with respect to the Notes of such series
in accordance with the Registration Rights Agreement, will be treated as a single series or class for all purposes under the Indenture,
including, without limitation, waivers, amendments and redemptions; provided that, if any such additional Notes are not fungible
with the existing Notes for Federal income tax purposes, such additional Notes will have a separate CUSIP number.

 

i.           
The Notes shall initially be issued only (A) to persons reasonably believed to be QIBs in reliance on Rule 144A
or (B) outside the United States, to persons other than “U.S. persons” as defined in Rule 902 under the Securities
Act, in compliance with Regulation S. Notes may thereafter be transferred to, among others, purchasers reasonably believed
to be QIBs, and purchasers in reliance on Regulation S, subject to the restrictions on transfer set forth herein. Notes initially
issued pursuant to Rule 144A shall be issued in the form of one or more permanent global securities in fully registered form
(collectively, the “Rule 144A Global Note”) and Notes initially issued pursuant to Regulation S shall
be issued in the form of one or more permanent global securities in fully registered form (collectively, the “Regulation S
Global Note”), in each case without interest coupons and with the Global Notes Legend and the applicable Restricted Notes
Legend set forth in Section 2.7(e)(i) hereof, which shall be deposited on behalf of the purchasers of the Notes represented thereby
with the Common Depositary and shall be registered in the name of USB Nominees (UK) Limited, as nominee of the Common Depositary
for such Global Note or Global Notes, duly executed by the Company and authenticated by the Trustee as provided in this Supplemental
Indenture.

 

    	 	7	 

     

    

 

ii.           
Beneficial interests in Regulation S Global Notes may be exchanged for interests in Rule 144A Global Notes of
the same series if (1) such exchange occurs in connection with a transfer of Notes in compliance with Rule 144A and (2) the
transferor of the beneficial interest in the Regulation S Global Note first delivers to the Trustee a written certificate
(in the form of the Form of Exchange Certificate attached to the applicable Exhibit hereto) to the effect that the beneficial interest
in the Regulation S Global Note is being transferred to a Person (A) who the transferor reasonably believes to be a QIB,
(B) purchasing for its own account or the account of a QIB in a transaction meeting the requirements of Rule 144A, and
(C) in accordance with all applicable securities laws of the States of the United States and other jurisdictions.

 

iii.           
Beneficial interests in Rule 144A Global Notes may be transferred to a Person who takes delivery in the form of an
interest in a Regulation S Global Note only if the transferor first delivers to the Trustee a written certificate (in the
form of Exhibit B hereto) to the effect that such transfer is being made in accordance with Rule 903 or 904 of Regulation S
(if applicable).

 

iv.           
The Rule 144A Global Notes and the Regulation S Global Notes are collectively referred to herein as “Global
Notes.”

 

The
terms and provisions contained in the Notes shall constitute, and are hereby expressly made, a part of this Supplemental Indenture,
and the Company and the Trustee, by their execution and delivery of this Supplemental Indenture, expressly agree to such terms
and provisions and to be bound thereby. However, to the extent any provision of any Note conflicts with the express provisions
of this Supplemental Indenture, the provisions of this Supplemental Indenture shall govern and be controlling.

 

(b)              
Book-Entry Provisions.  This Section 2.6(b) shall apply only to a Global Note deposited with the Common
Depositary. The Company shall execute and the Trustee shall, in accordance with this Section 2.6(b) and pursuant to an
order of the Company, authenticate and deliver initially one or more Global Notes that (A) shall be registered in the name
of USB Nominees (UK) Limited, as nominee of the Common Depositary for such Global Note or Global Notes and (B) shall be delivered
by the Trustee to such Common Depositary.

 

    	 	8	 

     

    

 

(c)              
Payment. The Company will make payments on the Notes in euro at the office of the Trustee (in the limited circumstances
specified in the Indenture), the Paying Agent or any paying agent the Company designates (which paying agent may include the Company).
At its option, the Company may make payments of interest by (i) check mailed to the address of the Person entitled thereto
as such address shall appear in the Security Register or (ii) wire transfer as directed by the Holder of any Note, in immediately
available funds to an account maintained by the Common Depositary or its nominee with respect to a Global Note, and to the Holder
of any Note or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive Note (x)
the Holder thereof shall have provided written wiring instructions to the Paying Agent on or before the related Record Date and
(y) if appropriate instructions for any such wire transfer are not received by the related Record Date, then such payment
shall be made by check mailed to the address of such Holder specified in the Security Register. The Company will make interest
payments to the Holder in whose name the Note is registered at the close of business on the Record Date for the interest payment.

 

Payment of principal in respect of the Notes
and payment of accrued interest payable on redemption of the Notes (other than on an interest payment date) will be made to the
Persons shown in the Security Register at the close of business on the Record Date, subject to surrender (or in the case of partial
payment only, endorsement) of the relevant note, at the specified office of the Paying Agent. Payments of interest due on any interest
payment date will be made to the Persons shown in the Security Register at close of business on the Record Date. Payments of all
other amounts will be made as provided in the Indenture.

 

If the principal of or any premium or interest
on the Notes is payable on a day that is not a Payment Business Day, the payment will be made on the following Payment Business
Day without the accrual of any interest on that payment.

 

For these purposes “Payment Business
Day” means any day that is:

 

		a)	a day on which commercial banks and foreign exchange markets settle payments and are open for general business (including dealing
in foreign exchange and foreign currency deposits) in, in the case of Definitive Notes only, the relevant place of presentation;

 

		b)	a day on which the TARGET2 System is open; and

 

		c)	in the case of any payment in respect of a Global Note, a day on which Euroclear and/or Clearstream, as the case may be, settle(s)
payments in euro.

 

For these purposes “TARGET2 System”
means the Trans-European Automatic Realtime Gross Settlement Express Transfer (TARGET2) System.

 

All payments of any amounts paid to or to
the order of USB Nominees (UK) Limited, as nominee for the Common Depositary for Euroclear and Clearstream shall be valid and,
to the extent of the sums so paid, effectual to satisfy and discharge the liability of the Company for the moneys payable on the
Notes.

 

    	 	9	 

     

    

 

The Company has designated the Paying Agent
as its paying agent for payments on Notes. The Company may at any time designate additional paying agents or rescind the designation
of any paying agent or approve a change in the office through which any paying agent acts.

 

The Trustee or Paying Agent, as applicable,
will repay to the Company on the Company’s written request any funds they hold for payments on the Notes that remain unclaimed
for two years after the date upon which that payment has become due. After repayment to the Company, Holders entitled to those
funds must look only to it for payment.

 

(d)              
Definitive Notes.  Except as provided in this Section 2.6, owners of a beneficial interest in the Global
Notes will not have Notes registered in their names, will not receive physical delivery of Definitive Notes and will not be considered
the registered owners or “holders” thereof under the Indenture for any purpose.

 

Section 2.7.          
Transfer and Exchange.

 

(a)              
Transfer and Exchange of Definitive Notes.  When Definitive Notes are presented to the Security Registrar with
a request:

 

(i)                
to register the transfer of such Definitive Notes; or

 

(ii)             
to exchange such Definitive Notes for an equal principal amount of Definitive Notes of other authorized denominations, the
Security Registrar shall register the transfer or make the exchange as requested if its reasonable requirements for such transaction
are met; provided, however, that the Definitive Notes surrendered for transfer or exchange:

 

(A)            
shall be duly endorsed or accompanied by a written instrument of transfer in form reasonably satisfactory to the
Company and the Security Registrar, duly executed by the Holder thereof or his attorney duly authorized in writing; and

 

(B)             
are accompanied by the following additional information and documents, as applicable:

 

(x)       certification
(in the form set forth on the reverse side of the Initial Note) that such definitive Note is being transferred (A) to a QIB in
accordance with Rule 144A or (B) outside the United States in an offshore transaction within the meaning of Regulation S and in
compliance with Rule 903 or Rule 904 under the Securities Act; and

 

(y)        (1)
if such Definitive Notes are being delivered to the Security Registrar by a Holder for registration in the name of such Holder,
without transfer, a certification from such Holder to that effect (in the form set forth on the reverse side of the Note); or (2)
if such Definitive Notes are being transferred to the Company, a certification to that effect (in the form satisfactory to the
Trustee).

 

    	 	10	 

     

    

 

(b)              
Restrictions on Transfer of a Definitive Note for a Beneficial Interest in a Global Note.  A Definitive Note
may not be exchanged for a beneficial interest in a Global Note except upon satisfaction of the requirement set forth below. Upon
receipt by the Trustee of a Definitive Note, duly endorsed or accompanied by a written instrument of transfer in form reasonably
satisfactory to the Company and the Security Registrar, together with (i) certification (in the form set forth on the reverse side
of the Initial Note) that such definitive Note is being transferred (A) to a QIB in accordance with Rule 144A or (B) outside
the United States in an offshore transaction within the meaning of Regulation S and in compliance with Rule 903 or Rule 904
under the Securities Act and (ii) written instructions directing the Trustee to make an adjustment on its books and records with
respect to such Global Note to reflect an increase in the aggregate principal amount of the Notes represented by the Global Note,
such instructions to contain information regarding the Common Depositary account to be credited with such increase, then the Trustee
shall cancel such Definitive Note and cause the aggregate principal amount of Notes represented by the Global Note to be increased
by the aggregate principal amount of the Definitive Note to be exchanged and shall credit or cause to be credited to the account
of the Person specified in such instructions a beneficial interest in the Global Note equal to the principal amount of the Definitive
Note so canceled. If no Global Notes are then outstanding and the Global Note has not been previously exchanged for certificated
securities pursuant to this Section 2.7, the Company shall issue and the Trustee shall authenticate, upon receipt of a Company
Order, a new Global Note in the appropriate principal amount.

 

(c)              
Exchange of Global Notes for Definitive Notes. A Global Note shall be exchanged by the Company for Definitive Notes
only if:

 

(i)                
an Event of Default has occurred and is continuing; or

 

(ii)             
either Euroclear or Clearstream is closed for business for a continuous period of 14 days or more (other than by reason
of holiday, statutory or otherwise) or announces an intention permanently to cease business or does in fact do so and no alternative
clearing system satisfactory to the Trustee is available; or

 

(iii)           
the Company would suffer a disadvantage as a result of a change in laws or regulations (taxation or otherwise) or as a result
of a change in the practice of Euroclear and/or Clearstream which would not be suffered were the Notes in definitive form and a
certificate to such effect signed by an authorized signatory of the Company is given to the Trustee.

 

In the case of (i) or (ii) above,
the Holder of a Global Note (acting on behalf of one or more of the accountholders) or the Trustee may give notice to the Company
and, in the case of (iii) above, the Company may give notice to the Trustee and the Holders of Notes, of its intention to
exchange a Global Note for Definitive Notes on or after the Exchange Date (as defined below).

 

    	 	11	 

     

    

 

On or after the Exchange Date the Holder
of the Global Note may, or in the case of (iii) above, shall surrender it to or to the order of the Paying Agent. In exchange
for the Global Note, the Company shall deliver, or procure the delivery of, an equal aggregate principal amount of Definitive Notes,
security printed in accordance with any applicable legal and stock exchange requirements. On exchange of the Global Note, the Company
will procure that it is cancelled and, if the Holder so requests, returned to the Holder together with any relevant Definitive
Notes.

 

For these purposes, “Exchange Date”
means a day specified in the notice requiring exchange falling not less than 60 days after that on which the notice requiring
exchange is given and being a day on which banks are open for general business in London, the place in which the specified office
of the Paying Agent is located and, except in the case of exchange pursuant to (ii) above, in the place in which Euroclear
and Clearstream are located.

 

In all cases, Definitive Notes delivered
in exchange for any Global Note or beneficial interests in Global Notes will be registered in the names, and issued in any approved
denominations, requested by or on behalf of the Holder of the relevant Global Notes.

 

In the event that Global Notes are exchanged
for Definitive Notes prior to the consummation of the Registered Exchange Offer or the effectiveness of the shelf registration
statement with respect to such Notes, such Notes may be exchanged only in accordance with such procedures as are substantially
consistent with the provisions of this section (including the certification requirements set forth on the reverse of the Initial
Notes intended to ensure that such transfers comply with Rule 144, Rule 144A, Regulation S or such other applicable exemption from
registration under the Securities Act, as the case may be) and such other procedures as may from time to time be adopted by the
Company.

 

None of the Company, the Trustee, the Paying
Agent or the Security Registrar will be liable for any delay by the Holder of the relevant Global Notes in identifying the Holders
of beneficial interests in the Global Notes, and each such Person may conclusively rely on, and will be protected in relying on,
instructions from Euroclear or Clearstream for all purposes (including with respect to the registration and delivery, and the respective
principal amounts, of the Definitive Notes to be issued).

 

    	 	12	 

     

    

 

(d)              
Restrictions on Transfer of Regulation S Global Notes.

 

(i)       Prior
to the expiration of the Restricted Period, interests in a Regulation S Global Note may only be held through Euroclear or
Clearstream. During the Restricted Period, beneficial ownership interests in a Regulation S Global Note may only be sold,
pledged or transferred through Euroclear or Clearstream in accordance with the Applicable Procedures and only (A) to the Company,
(B) so long as such security is eligible for resale pursuant to Rule 144A, to a person whom the selling holder reasonably
believes is a QIB that purchases for its own account or for the account of a QIB to whom notice is given that the resale, pledge
or transfer is being made in reliance on Rule 144A, (C) in an offshore transaction in accordance with Regulation S,
(D) pursuant to an available exemption from registration under the Securities Act or (E) pursuant to an effective registration
statement under the Securities Act, in each case in accordance with any applicable securities laws of any state of the United States;
provided, however, that prior to the expiration of the Restricted Period, transfers of beneficial interests in a
Regulation S Global Note may not be made to a U.S. person or for the account or benefit of a U.S. person. Prior to the expiration
of the Restricted Period, transfers by an owner of a beneficial interest in a Regulation S Global Note to a transferee who
takes delivery of such interest through a Rule 144A Global Note shall be made only in accordance with the Applicable Procedures,
pursuant to Rule 144 or Rule 144A and upon receipt by the Trustee of a written certification from the transferor of the
beneficial interest in the form provided on the reverse of the Initial Note to the effect that such transfer is being made to a
person whom the transferor reasonably believes is a QIB within the meaning of Rule 144A in a transaction meeting the requirements
of Rule 144A. Such written certification shall no longer be required after the expiration of the Restricted Period. In the
case of a transfer of a beneficial interest in a Regulation S Global Note for an interest in a Rule 144A Global Note,
the transferee must, at the request of the Company, deliver an opinion of counsel reasonably acceptable to the Company stating
that the proposed transfer is being made pursuant to an exemption from, or in a transaction not subject to, the registration requirements
of the Securities Act.

 

(ii)       Upon
the expiration of the Restricted Period, beneficial ownership interests in a Regulation S Global Note shall be transferable
in accordance with applicable law and the other terms of the Indenture.

 

(e)              
Legends.

 

(i)       Except
as permitted by the following paragraphs (ii), (iii), (iv) or (v), each Note certificate evidencing the Global Notes and the
Definitive Notes (and all Notes issued in exchange therefor or in substitution thereof) shall bear a legend in substantially the
following form (each defined term in the legend being defined as such for purposes of the legend only):

 

THIS SECURITY HAS NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

    	 	13	 

     

    

 

NEITHER THIS SECURITY NOR ANY INTEREST
OR PARTICIPATION HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE
OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY,
BY ITS ACCEPTANCE HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES,
TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT
IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE
DATE HEREOF OR ANY OTHER ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH
ABBVIE INC. OR ANY AFFILIATE OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO
ABBVIE INC. OR ANY SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE
SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A “QUALIFIED INSTITUTIONAL BUYER” AS DEFINED IN RULE 144A THAT PURCHASES
FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE
IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS AND SALES
TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, (E) TO
AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7) UNDER THE SECURITIES
ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF ANOTHER INSTITUTIONAL
ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT PURPOSES AND NOT
WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR (F) PURSUANT
TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S AND THE
TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE DELIVERY
OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED UPON
THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

Each Note evidencing a Global Note
offered and sold to QIBs pursuant to Rule 144A shall bear a legend in substantially the following form:

 

EACH PURCHASER OF THIS SECURITY
IS HEREBY NOTIFIED THAT THE SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE
SECURITIES ACT PROVIDED BY RULE 144A THEREUNDER.

 

    	 	14	 

     

    

 

Each Note evidencing a Global Note
offered and sold to non-U.S. persons outside the United States in reliance on Regulation S shall bear a legend substantially in
the following form:

 

BY ITS ACQUISITION HEREOF, THE HOLDER
HEREOF REPRESENTS THAT IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY
IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.

 

Each Global Note shall bear a legend
substantially in the following form:

 

THIS SECURITY IS A SECURITY IN A
GLOBAL FORM WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED,
AS NOMINEE OF ELAVON FINANCIAL SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV
(“EUROCLEAR”) AND CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED
IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY
THE COMMON DEPOSITARY TO A NOMINEE THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY
OR BY THE COMMON DEPOSITARY OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR
COMMON DEPOSITARY. THIS GLOBAL SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE
OF THE COMMON DEPOSITARY ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER
THAN A TRANSFER OF THIS SECURITY AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

Each Note in definitive form shall
bear the following additional legend:

 

IN CONNECTION WITH ANY TRANSFER,
THE HOLDER WILL DELIVER TO THE SECURITY REGISTRAR AND TRANSFER AGENT SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH TRANSFER AGENT
MAY REASONABLY REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.

 

(ii)       Upon
any sale or transfer of a Transfer Restricted Note that is a definitive Note, the Security Registrar shall permit the Holder thereof
to exchange such Transfer Restricted Note for a definitive Note that does not bear the legends set forth above and rescind any
restriction on the transfer of such Transfer Restricted Note if the Holder certifies in writing to the Security Registrar that
its request for such exchange was made in reliance on Rule 144 (such certification to be in the form set forth on the reverse
of the Initial Note).

 

    	 	15	 

     

    

 

(iii)       After
a transfer of any Initial Notes during the period of the effectiveness of a shelf registration statement with respect to such Initial
Notes, as the case may be, all requirements pertaining to the Restricted Notes Legend on such Initial Notes shall cease to apply
and the requirements that any such Initial Notes be issued in global form shall continue to apply.

 

(iv)       Upon
the consummation of a Registered Exchange Offer with respect to the Initial Notes pursuant to which Holders of such Initial Notes
are offered Exchange Notes in exchange for their Initial Notes, all requirements pertaining to Initial Notes that Initial Notes
be issued in global form shall continue to apply, and Exchange Notes in global form without the Restricted Notes Legend shall be
available to Holders that exchange such Initial Notes in such Registered Exchange Offer.

 

(v)       Upon
a sale or transfer after the expiration of the Restricted Period of any Initial Note acquired pursuant to Regulation S, all
requirements that such Initial Note bear the Restricted Notes Legend shall cease to apply and the requirements requiring any such
Initial Note be issued in global form shall continue to apply.

 

(f)               
By its acceptance of any Note bearing any legend in Section 2.7(e)(i) hereof, each Holder of such Note acknowledges
the restrictions on transfer of such Note set forth in this Supplemental Indenture and in such legend in Section 2.7(e)(i)
hereof and agrees that it shall transfer such Note only as provided in this Supplemental Indenture.

 

(g)              
Cancellation or Adjustment of Global Note. At such time as all beneficial interests in a Global Note have either
been exchanged for Definitive Notes, transferred, redeemed, repurchased or canceled, such Global Note shall be returned by the
Common Depositary to the Security Registrar for cancellation or retained and canceled by the Security Registrar. At any time prior
to such cancellation, if any beneficial interest in a Global Note is exchanged for Definitive Notes, transferred in exchange for
an interest in another Global Note, redeemed, repurchased or canceled, the principal amount of Notes represented by such Global
Note shall be reduced and an adjustment shall be made on the books and records of the Security Registrar with respect to such Global
Note, by the Security Registrar, to reflect such reduction.

 

(h)              
Obligations with Respect to Transfers and Exchanges of Notes.

 

(i)                
To permit registrations of transfers and exchanges, the Company shall execute and the Trustee shall authenticate Definitive
Notes and Global Notes at the Security Registrar’s request.

 

    	 	16	 

     

    

 

(ii)             
No service charge shall be made for any registration of transfer or exchange of the Notes, but the Company or the Security
Registrar may require payment of a sum sufficient to cover any transfer tax, assessments, or similar governmental charge payable
in connection therewith (other than any such transfer taxes, assessments or similar governmental charge payable upon exchange or
transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

(i)                
Prior to the due presentation for registration of transfer of any Note, the Company, the Trustee, the Paying Agent or the
Security Registrar may deem and treat the Person in whose name a Note is registered as the absolute owner of such Note for the
purpose of receiving payment of principal of and interest on such Note and for all other purposes whatsoever, whether or not such
Note is overdue, and none of the Company, the Trustee, the Paying Agent or the Security Registrar shall be affected by notice to
the contrary.

 

(j)                
The Company hereby appoints the Security Registrar as Security Registrar for the Notes. Neither the Company nor the Security
Registrar shall be required to register the transfer of or exchange Notes of any series (i) during a period beginning at the
opening of business 15 days before the day of the mailing of a notice of redemption of Notes of that series selected for redemption
under Section 11.3 of the Indenture and ending at the close of business on the day of such mailing, or (ii) so selected
for redemption in whole or in part, except the unredeemed portion of any Note being redeemed in part.

 

(k)              
All Notes issued upon any transfer or exchange pursuant to the terms of this Supplemental Indenture shall evidence the same
Debt and shall be entitled to the same benefits under the Indenture as the Notes surrendered upon such transfer or exchange.

 

(l)                
No Obligation of the Trustee.

 

(i)                
The Trustee shall have no responsibility or obligation to any beneficial owner of a Global Note, a member of, or a participant
in, the Common Depositary or any other Person with respect to the accuracy of the records of the Common Depositary or its nominee,
with respect to any ownership interest in the Notes or with respect to the delivery to any beneficial owner or other Person (other
than the Common Depositary) of any notice (including any notice of redemption or repurchase) or the payment of any amount, under
or with respect to such Notes. All notices and communications to be given to the Holders and all payments to be made to Holders
under the Notes shall be given or made only to the Holders (which shall be the Common Depositary or its nominee in the case of
a Global Note). The rights of beneficial owners in any Global Note shall be exercised only through the Common Depositary subject
to the applicable rules and procedures of the Common Depositary. The Trustee may rely and shall be fully protected in relying
upon information furnished by the Common Depositary with respect to any beneficial owners.

 

    	 	17	 

     

    

 

(ii)             
The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on
transfer imposed under this Supplemental Indenture or under applicable law with respect to any transfer of any interest in any
Note (including any transfers between or among beneficial owners in any Global Note) other than to require delivery of such certificates
and other documentation or evidence as are expressly required by, and to do so if and when expressly required by, the terms of
this Supplemental Indenture, and to examine the same to determine substantial compliance as to form with the express requirements
hereof.

 

Article 3
 

TRUSTEE AND PAYING AGENT

 

 

Section 3.1.          
Appointments. The Paying Agent for the Notes shall initially be Elavon Financial Services
DAC, U.K. Branch. The Company hereby initially designates the Corporate Trust Office of the Paying Agent as the office to be maintained
by it where Notes may be presented for payment and where notices to or demands upon the Company in respect of the Notes or the
Indenture may be served. The Security Registrar and Transfer Agent for the Notes shall initially be U.S. Bank National Association
and the Company hereby initially designates the Corporate Trust Office of the Security Registrar and Transfer Agent as the office
to be maintained by it where Notes may be presented for registration of transfer or exchange. The Company reserves the right at
any time to vary or terminate the appointment of the Paying Agent or Security Registrar, to appoint additional or other paying
agents or another security registrar and to approve any change in the office through which any paying agent or security registrar
acts. In furtherance of such appointment, the Trustee is hereby authorized and directed to execute and deliver the Agency Agreement.
The Trustee shall not be liable for any act or omission of the Paying Agent, Security Registrar, Transfer Agent, Common Depositary,
Euroclear or Clearstream. In considering the interests of Holders of the Notes while any relevant Global Notes are held on behalf
of Euroclear and Clearstream, the Trustee may have regard to any information provided to it by such clearing systems as to the
identity (either individually or by category) of their accountholders and may consider such interests as if such accountholders
were Holders of the relevant Global Notes and interests therein.

 

Article 4
 

REDEMPTION

 

Section 4.1.          
Optional Redemption of the Floating Rate Notes. The Floating Rate Notes may not be redeemed
at the Company’s option prior to their stated maturity, except in the case of certain changes in withholding tax laws, as
discussed below in Section 4.3. 

 

Section 4.2.          
Optional Redemption of the Fixed Rate Notes.

 

(a)              
At any time prior to the Par Call Date applicable to a series of Fixed Rate Notes, the Company may redeem some or all of
the Fixed Rate Notes of such series at its option, in each case at a redemption price equal to the greater of:

 

(i)                
100% of the principal amount of the Fixed Rate Notes of that series to be redeemed; and

 

    	 	18	 

     

    

 

(ii)             
the sum of the present values of the remaining scheduled payments (through the Par Call Date with respect to such Notes
assuming for such purpose that such Notes matured on the applicable Par Call Date) of principal and interest on the Notes to be
redeemed (exclusive of interest accrued to the date of redemption) on such Fixed Rate Notes to be redeemed discounted to the date
of redemption on an annual basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 20 basis points
for the 2021 Notes, 25 basis points for the 2023 Notes, 25 basis points for the 2024 Notes, 35 basis points for the 2028 Notes
and 30 basis points for the 2029 Notes.

 

In
each case, the Company will pay accrued and unpaid interest on the principal amount being redeemed to, but excluding, the date
of redemption.

 

(b)              
In addition, at any time on or after the Par Call Date applicable to a series of Fixed Rate Notes, the Company may redeem
some or all of the Fixed Rate Notes of that series at its option, in each case at a redemption price equal to 100% of the principal
amount of the Fixed Rate Notes of that series to be redeemed, plus, in each case, accrued and unpaid interest on the principal
amount being redeemed to, but excluding, the date of redemption.

 

(c)              
Notice of redemption will be mailed at least 15 but not more than 60 days before the redemption date (i) in the case of
Global Notes, to and through Euroclear or Clearstream for communication by them to each Holder of the Fixed Rate Notes to be redeemed,
or (ii) in the case of Definitive Notes, to each Holder of record of the Fixed Rate Notes to be redeemed at its registered address.
The notice of redemption for the Fixed Rate Notes will state, among other things, the series and amount of Fixed Rate Notes to
be redeemed, the redemption date, the redemption price and the place or places that payment will be made upon presentation and
surrender of Fixed Rate Notes to be redeemed. Any redemption or notice of redemption may, at the Company’s discretion, be
subject to one or more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until such
time as any or all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the close
of business two business days prior to the redemption date if any such redemption has been rescinded or delayed, and upon receipt
the Trustee shall provide such notice to each Holder of the Fixed Rate Notes in the same manner in which the notice of redemption
was given. Unless the Company defaults in the payment of the redemption price, interest will cease to accrue on any Fixed Rate
Notes that have been called for redemption at the redemption date. If fewer than all of the Fixed Rate Notes of a series are to
be redeemed at any time, (i) in the case of Fixed Rate Notes represented by a Global Note, the Fixed Rate Notes will be selected
in accordance with the rules of Euroclear and/or Clearstream (to be reflected in the records of Euroclear and Clearstream as either
a pool factor or a reduction in nominal amount, at their discretion), or (ii) in the case of Definitive Notes, the Trustee will
select the particular Fixed Rate Notes or portions thereof for redemption from the outstanding Fixed Rate Notes not previously
redeemed by random lot.

 

    	 	19	 

     

    

 

Section 4.3.          
Redemption for Tax Reasons. If, as a result of any change in, or amendment to, the laws
(or any regulations or rulings promulgated under the laws) of the United States (or any taxing authority in the United States),
or any change in, or amendment to, an official position or judicial precedent regarding the application or interpretation of such
laws, regulations or rulings, which change or amendment is announced or becomes effective on or after the date of the Offering
Memorandum and Consent Solicitation Statement, the Company becomes or, based upon a written opinion of independent counsel selected
by it, will become obligated to pay Additional Amounts (as described in Article 5 hereunder) with respect to a series of Notes,
then the Company may at any time at its option redeem, in whole, but not in part, the Notes of such series on not less than 30
nor more than 60 days’ prior notice, (i) in the case of Notes represented by a Global Note, to and through Euroclear
or Clearstream for communication by them to the Holders of interests in the Notes to be so redeemed, or (ii) in the case of
Definitive Notes, to each Holder of record of the Notes to be redeemed at its registered address, at a redemption price equal to
100% of their principal amount plus accrued and unpaid interest to the redemption date.

 

Article 5
 

PAYMENT OF ADDITIONAL
AMOUNTS

 

Section 5.1.          
General. The Company will, subject to the exceptions and limitations set forth below, pay
as additional interest on each series of the Notes such additional amounts (the “Additional Amounts”) as are
necessary in order that the net amount of the principal of, and premium, if any, and interest on such Notes received by a beneficial
owner who is not a U.S. person (as defined below), after withholding or deduction for any future tax, assessment or other governmental
charge imposed by the United States or a taxing authority in the United States, will not be less than the amount provided in the
Notes to be then due and payable; provided, however,
that the foregoing obligation to pay Additional Amounts shall not apply:

 

(a)              
to any tax, assessment or other governmental charge that would not have been imposed but for the Holder (or the beneficial
owner for whose benefit such Holder holds such Note), or a fiduciary, settlor, beneficiary, member or shareholder of the Holder
if the Holder is an estate, trust, partnership or corporation, or a Person holding a power over an estate or trust administered
by a fiduciary holder, being considered as:

 

(i)                
being or having been engaged in a trade or business in the United States or having or having had a permanent establishment
in the United States;

 

(ii)             
having a current or former connection with the United States (other than a connection arising solely as a result of the
ownership of the Notes or the receipt of any payment or the enforcement of any rights thereunder), including being or having been
a citizen or resident of the United States;

 

(iii)           
being or having been a personal holding company, a passive foreign investment company or a controlled foreign corporation
for U.S. federal income tax purposes or a corporation that has accumulated earnings to avoid U.S. federal income tax;

 

    	 	20	 

     

    

 

(iv)            
being or having been a “10-percent shareholder” of the Company as defined in section 871(h)(3) of
the U.S. Internal Revenue Code of 1986, as amended (the “Code”), or any successor provision; or

 

(v)              being a bank receiving payments on an extension of credit made pursuant to a loan agreement entered into in the ordinary
course of its trade or business;

 

(b)              
to any Holder that is not the sole beneficial owner of the Notes, or a portion of the Notes, or that is a fiduciary, partnership
or limited liability company, but only to the extent that a beneficial owner with respect to the Holder, a beneficiary or settlor
with respect to the fiduciary, or a beneficial owner or member of the partnership or limited liability company would not have been
entitled to the payment of an Additional Amount had the beneficiary, settlor, beneficial owner or member received directly its
beneficial or distributive share of the payment;

 

(c)              
to any tax, assessment or other governmental charge that would not have been imposed but for the failure of the Holder or
beneficial owner or any other Person to comply with certification, identification or information reporting requirements concerning
the nationality, residence, identity or connection with the United States of the Holder or beneficial owner of the Notes, if compliance
is required by statute, by regulation of the United States or any taxing authority therein or by an applicable income tax treaty
to which the United States is a party as a precondition to exemption from such tax, assessment or other governmental charge;

 

(d)              
to any tax, assessment or other governmental charge that is imposed otherwise than by withholding by the Company or a paying
agent from the payment;

 

(e)              
to any tax, assessment or other governmental charge that would not have been imposed but for a change in law, regulation,
or administrative or judicial interpretation that becomes effective more than 15 days after the payment becomes due or is
duly provided for, whichever occurs later;

 

(f)               
to any estate, inheritance, gift, sales, excise, transfer, wealth, capital gains or personal property tax or similar tax,
assessment or other governmental charge;

 

(g)              
to any tax, assessment or other governmental charge required to be withheld by any paying agent from any payment of principal
of or interest on any Note, if such payment can be made without such withholding by at least one other paying agent;

 

(h)              
to any tax, assessment or other governmental charge that would not have been imposed but for the presentation by the Holder
of any Note, where presentation is required, for payment on a date more than 30 days after the date on which payment became
due and payable or the date on which payment thereof is duly provided for, whichever occurs later;

 

(i)                
to any tax, assessment or other governmental charge that would not have been imposed or withheld but for the beneficial
owner being a bank (i) purchasing the Notes in the ordinary course of its lending business or (ii) that is neither (A) buying
the Notes for investment purposes only nor (B) buying the Notes for resale to a third-party that either is not a bank or holding
the Notes for investment purposes only;

 

    	 	21	 

     

    

 

(j)                
to any tax, assessment or other governmental charge imposed under Sections 1471 through 1474 of the Code (or any amended
or successor provisions), any current or future regulations or official interpretations thereof, any agreement entered into pursuant
to Section 1471(b) of the Code, any intergovernmental agreement entered into in connection with the implementation of such
sections of the Code or any fiscal or regulatory legislation, rules or practices adopted pursuant to any such intergovernmental
agreement; or

 

(k)              
in the case of any combination of items (a) through (j).

 

Section 5.2.          
No Other Requirements. The Notes are subject in all cases to any tax, fiscal or other law
or regulation or administrative or judicial interpretation applicable to the Notes. Except as specifically provided under this
Article V, the Company shall not be required to make any payment for any tax, assessment or other governmental charge imposed by
any government or a political subdivision or taxing authority of or in any government or political subdivision.

 

Section 5.3.          
Definition. As used under this Article 5, the term “United States” means
the United States of America, the states of the United States, and the District of Columbia, and the term “U.S. person”
means any individual who is a citizen or resident of the United States for U.S. federal income tax purposes, a corporation, partnership
or other entity created or organized in or under the laws of the United States, any state of the United States or the District
of Columbia, or any estate or trust the income of which is subject to U.S. federal income taxation regardless of its source.

 

Article 6

AMENDMENTS TO THE BASE INDENTURE

 

Section 6.1.          
Amendment to Section 4.1 of the Indenture. Solely as it relates to the Notes, Section 4.1
of the Indenture shall be amended by replacing subsection (1)(B) with the following:

 

(B)        all
of the Securities of such series not theretofore delivered to the Trustee for cancellation

 

(i)              
have become due and payable,

 

(ii)            
will become due and payable at their Stated Maturity within one year, or

 

(iii)             
if redeemable at the Company’s option, are to be called for redemption within one year under arrangements satisfactory
to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company,

 

    	 	22	 

     

    

 

and the Company, in the case of (i), (ii) or (iii) above,
has irrevocably deposited or caused to be deposited with the Trustee funds in an amount sufficient to pay and discharge the entire
indebtedness on the Securities of such series not theretofore delivered to the Trustee for cancellation, for principal of, premium,
if any, and interest on the Securities of such series to the date of such deposit (in the case of Securities which have become
due and payable), or to their Stated Maturity or the Redemption Date, as the case may be (provided that in connection with any
discharge relating to any redemption that requires the payment of a premium, the amount deposited shall be sufficient for purposes
of the Indenture to the extent that an amount is deposited with the Trustee equal to the premium calculated as of the date of the
notice of redemption, with any deficit as of the Redemption Date only required to be deposited with the Trustee on or prior to
the Redemption Date), together with irrevocable instructions from the Company directing the Trustee to apply such funds to the
payment thereof at Maturity or the Redemption Date, as the case may be.

 

Section 6.2.          
Amendment to Section 5.1 to the Indenture. Solely as it relates to the Notes, Section 5.1
of the Indenture shall be amended by: 

 

(a)       
replacing subsection (4) with the following: “default in the performance, or breach, of any covenant or warranty of the Company
in this Indenture (other than a covenant or warranty a default in whose performance or whose breach is elsewhere in this Section specifically
dealt with or which has expressly been included in this Indenture solely for the benefit of series of Securities other than that
series), and continuance of such default or breach for a period of 90 days after the giving of written notice to the Company by
the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal amount of the Outstanding Securities
of that series a written notice specifying such default or breach and requiring it to be remedied and stating that such notice
is a “Notice of Default” hereunder (provided that such notice may not be given with respect to any action taken, and
reported publicly or to Holders of the Securities more than two years prior to such notice);” and

 

(b)       adding
the following paragraph at the end of Section 5.1: “Any time period in this Indenture to cure any actual or alleged default
or Event of Default may be extended or stayed by a court of competent jurisdiction.”

 

Section 6.3.          
Amendment to Section 11.2 to the Indenture. Solely as it relates to the Notes, Section
11.2 of the Indenture shall be amended by replacing “45 days” with “30 days.”

 

Section 6.4.          
Amendment to Section 11.3 to the Indenture. Solely as it relates to the Notes, Section
11.3 of the Indenture shall be amended by replacing “45 days” with “30 days” in each instance it appears.

 

Section 6.5.          
Amendment to Section 11.4 to the Indenture.

 

(a)              
Solely as it relates to the Notes, Section 11.4 of the Indenture shall be amended by replacing the first sentence with the
following: “Notice of redemption will be mailed at least 15 but not more than 60 days before the redemption date (i) in the
case of Global Notes, to and through Euroclear or Clearstream for communication by them to each Holder of Securities to be redeemed,
or (ii) in the case of Definitive Notes, to each Holder of record of Securities to be redeemed at its registered address”;
and

 

    	 	23	 

     

    

 

(b)              
Solely as it relates to the Notes, Section 11.4 of the Indenture shall be amended by adding the following sentence to the
end of Section 11.4: “Any redemption or notice of redemption may, at the Company’s discretion, be subject to one or
more conditions precedent, and, at the Company’s discretion, the redemption date may be delayed until such time as any or
all such conditions shall be satisfied. The Company shall provide written notice to the Trustee prior to the close of business
two business days prior to the redemption date if any such redemption has been rescinded or delayed, and upon receipt the Trustee
shall provide such notice to each Holder of Securities in the same manner in which the notice of redemption was given.”

 

Section 6.6.          
Amendment to Section 13.4 of the Indenture.

 

(a)              
Solely as it relates to the Notes, Section 13.4 of the Indenture shall be amended by replacing subsections (5) and
(6) with the following:

 

		(5)	In the case of an election under Section 13.2, the Company shall have delivered to the Trustee an Opinion of Counsel stating
that (x) the Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (y) since
the date of this Indenture there has been a change in the applicable Federal income tax law, in either case to the effect that,
and based thereon such opinion shall confirm that, the beneficial owners of the Outstanding Securities of such series will not
recognize income, gain or loss for Federal income tax purposes as a result of such defeasance and will be subject to Federal income
tax in the same manner as would have been the case if such defeasance had not occurred.

 

		(6)	In the case of an election under Section 13.3, the Company shall have delivered to the Trustee an Opinion of Counsel to
the effect that the beneficial owners of the Outstanding Securities of such series will not recognize income, gain or loss for
Federal income tax purposes as a result of such covenant defeasance and will be subject to Federal income tax in the same manner
as would have been the case if such covenant defeasance had not occurred.

 

(b)              
Solely with respect to the Notes, the term “U.S. Government Obligations,” defined in Section 13.4 of
the Indenture, shall be deleted and replaced with the following: “euro denominated securities that are direct obligations
(or certificates representing an ownership interest in such obligations) of a member state of the European Union as of the Issue
Date (including any agency or instrumentality thereof) for the payment of which the full faith and credit of such government is
pledged; provided that such member state has a long-term government debt rating of “A1” or higher by Moody’s
or “A+” or higher by S&P or the equivalent rating category of another internationally recognized rating agency.”

 

    	 	24	 

     

    

 

Article 7

MISCELLANEOUS PROVISIONS

 

Section 7.1.          
Ratification.  The Indenture, as supplemented and amended by this Supplemental Indenture, is in all respects hereby
adopted, ratified and confirmed.

 

Section 7.2.          
Counterparts.  This Supplemental Indenture may be executed in any number of counterparts, each of which when so
executed shall be deemed an original, and all such counterparts shall together constitute but one and the same instrument.

 

Section 7.3.          
Governing Law.  THIS SUPPLEMENTAL INDENTURE AND EACH NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH
THE LAWS OF THE STATE OF NEW YORK.

 

Section 7.4.          
Conflict with Trust Indenture Act.  If any provision hereof limits, qualifies or conflicts with a provision of
the Trust Indenture Act that is required under such Act to be a part of and govern this Supplemental Indenture, the latter provision
shall control.  If any provision of this Supplemental Indenture modifies or excludes any provision of the Trust Indenture
Act that may be so modified or excluded, the latter provision shall be deemed to apply to this Supplemental Indenture as so modified
or to be excluded, as the case may be.

 

Section 7.5.          
The Trustee.  The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication,
shall be taken as the statements of the Company, and the Trustee assumes no responsibility for their correctness.  The Trustee
makes no representations as to the validity or sufficiency of this Supplemental Indenture or of the Securities.

 

[signature pages follow]

 

    	 	25	 

     

    

 

IN WITNESS WHEREOF, the parties hereto have
caused this Supplemental Indenture No. 9 to be duly executed as of the day and year first above written.

 

	 	ABBVIE INC.
	 	 	 
	 	By:	/s/
Scott T. Reents

	 		Name:	
Scott T. Reents

	 		Title:	Vice
President, Tax and Treasury

 

	 	U.S. BANK NATIONAL ASSOCIATION,

                                                                                as Trustee

	 
		By:	/s/
Linda Garcia

			Name:	Linda Garcia

			Title:	Vice
President

 

	 	ELAVON FINANCIAL SERVICES DAC,

                                                                                U.K. Branch, as Paying Agent

	 
		By:	/s/
David Harnett

		 	Name:	David Harnett

		 	Title:	Authorised
Signatory

 

	

                                                                                 
	U.S. BANK NATIONAL ASSOCIATION,

as Transfer Agent and Registrar

	 
		By:	/s/
Linda Garcia

		 	Name:	
Linda Garcia

		 	Title:	Vice
President

 

[Signature Page to Supplemental Indenture
No. 9]

 

    

     

    

 

EXHIBIT A1

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

    	 	A-1-1	 

     

    

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    	 	A-1-2	 

     

    

 

ABBVIE INC.

 

Senior Floating Rate Notes due 2020

 

 

	No. [●]	€[●]

 

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on November 15, 2020 (the “Maturity Date”), and to pay interest thereon,
at a variable rate, as provided on the reverse hereof, until the principal and any unpaid and accrued interest are paid or duly
provided for.

 

Payments of principal
of, and premium, if any, and interest on, this Security, including payments made upon any redemption of this Security, shall be
made by wire transfer of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of
exchange controls or other circumstances beyond the Company’s control (including the dissolution of the European Monetary
Union) or if the euro is no longer being used by the then member states of the European Monetary Union that have adopted the euro
as their currency or for the settlement of transactions by public institutions or within the international banking community, then
all payments in respect of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used.
In such circumstances, the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the
U.S. Federal Reserve Board as of the close of business on the second business day prior to the relevant payment date, or in the
event the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro
exchange rate available on or prior to the second business day prior to the relevant payment date as determined by the Company
in its sole discretion. Any payment in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default
under this Security or the Indenture. Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any
responsibility for any calculation or conversion in connection with the foregoing.

 

 

	1	Rule 144A Note CUSIP:	00287YDD8

	 	Regulation S Note CUSIP: 	U0029QBJ4

 

	2	Rule 144A Note ISIN:	XS2117753868

	 	Regulation S Note ISIN: 	XS2117753603

 

    	 	A-1-3	 

     

    

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    	 	A-1-4	 

     

    

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

Dated:               

 

	 	ABBVIE INC.
	 
	 	By:
	 	 	Name:
	 	 	Title:

 

    	 	A-1-5	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

Dated:                

 

	 	U.S. BANK NATIONAL ASSOCIATION,
	 	as Trustee
	 
	 	By:	 
	 	 	Authorized Signatory

 

    	 	A-1-6	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”) among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9,” and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Interest

 

Interest shall be paid at a rate per annum
equal to EURIBOR (as defined below), as determined on the applicable Interest Determination Date (as defined below) by the Calculation
Agent (as defined below), plus 0.350%; provided, however, that the minimum interest rate on the Securities shall
not be less than 0.000%. The interest rate on the Securities shall be reset on the first day of each Interest Period (as defined
below) other than the Initial Interest Period (as defined below).

 

The Company shall pay interest on the Securities
from the most recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”)
on the Floating Rate Notes due 2020 issued by Allergan that were accepted in the Exchange Offers, quarterly on February 15, May
15, August 15 and November 15 of each year (each, an “Interest Payment Date”), with the first interest payment
to be made on May 15, 2020.

 

An “Interest Period”
for the Securities means the period commencing on an Interest Payment Date and ending on the day preceding the next following Interest
Payment Date (or, in the case of the Initial Interest Period, commencing on the most recent date on which interest has been paid
or duly provided for by Allergan on the Floating Rate Notes due 2020 issued by Allergan that were accepted in the Exchange Offers).
The “Initial Interest Period” shall be February 15, 2020 through May 14, 2020. The “Interest Determination
Date” for an Interest Period shall be the second TARGET System Day (as defined below) preceding the first day of such
Interest Period (or, in the case of the Initial Interest Period, February 13, 2020).

 

All payments of interest on the Securities
due on any Interest Payment Date shall be made to the Persons in whose name the Securities are registered at the close of business
on the 15th calendar day immediately preceding the relevant Interest Payment Date (whether or not a Business Day (as defined below))
(each such date, a “Regular Record Date”). However, interest that the Company pays on the Maturity Date shall
be payable to the Person to whom the principal shall be payable. The amount of interest for each day that the Securities are outstanding
(the “Daily Interest Amount”) will be calculated by dividing the interest rate in effect for such day by 360
and multiplying the result by the principal amount of the Securities outstanding on such day. The amount of interest to be paid
on the Securities for each Interest Period will be calculated by adding such Daily Interest Amounts for each day in such Interest
Period.

 

    	 	A-1-7	 

     

    

 

If an Interest Payment Date, other than
the Maturity Date, falls on a day that is not a Business Day, the interest payment shall be postponed to the next day that is a
Business Day, except that if that Business Day is in the next succeeding calendar month, the Interest Payment Date shall be the
immediately preceding Business Day. If the Maturity Date of the Securities falls on a day that is not a Business Day, the payment
of interest and principal shall be made on the next succeeding Business Day, and no interest on such payment shall accrue for the
period from and after the Maturity Date. If any such Interest Payment Date, other than the Maturity Date, is postponed or brought
forward as described above, the amount of interest for the relevant Interest Period will be adjusted accordingly.

 

“EURIBOR”
shall be determined by the Calculation Agent in accordance with the following provisions:

 

		(a)	“EURIBOR,” with respect to any Interest Determination Date, shall be the offered
rate for deposits of euros having a maturity of three months that appears on “Reuters Page EURIBOR 01” (or such other
page as may replace “Reuters Page EURIBOR 01” on such service or any successor service for the purpose of displaying
eurozone interbank offered rates for euro-denominated deposits of major banks) at approximately 11:00 a.m., Brussels time, on such
Interest Determination Date. If no rate appears, then EURIBOR, in respect of that Interest Determination Date, shall be determined
in accordance with the provisions described in (b) below.

 

		(b)	If no offered rate appears on the “Reuters Page EURIBOR 01” on an Interest Determination
Date, as specified in (a) above, EURIBOR shall be determined for such Interest Determination Date on the basis of the rates at
approximately 11:00 a.m., Brussels time, on such Interest Determination Date at which deposits in euros are offered to prime banks
in the eurozone inter-bank market by the principal eurozone office of each of four major banks in such market selected and identified
by the Company (the “Reference Banks”), for a term of three months commencing on the first day of the applicable
Interest Period and in a principal amount of not less than €1,000,000 that is representative for a single transaction in euros
in such market at such time. The Company shall ensure the Calculation Agent is provided with the complete contact details of the
relevant personnel at each of the Reference Banks that they will be required to contact in order to obtain the relevant interest
rate. The Calculation Agent shall request the principal eurozone office of each of the Reference Banks to provide a quotation of
its rate. If at least two such quotations are provided, EURIBOR for such Interest Period shall be the arithmetic mean (rounded
upwards) of such quotations. If fewer than two such quotations are provided, EURIBOR for such Interest Period shall be the arithmetic
mean (rounded upwards) of the rates quoted at approximately 11:00 a.m., Brussels time, on such Interest Determination Date by three
major banks in the eurozone, selected and identified by the Company, for loans in euros to leading European banks, for a term of
three months, commencing on the first day of the applicable Interest Period and in a principal amount of not less than €1,000,000
that is representative for a single transaction in euros in such market at such time; provided, however,
that if the banks so selected do not provide quotes as specified above, the interest rate for the applicable Interest Period shall
be the same as the interest rate for the immediately preceding Interest Period, or, if none, the interest rate for the applicable
Interest Period shall be the interest rate with respect to the Initial Interest Period. 

 

    	 	A-1-8	 

     

    

 

Notwithstanding
the paragraph immediately above, if the Company, in its sole discretion, determines that EURIBOR has been permanently discontinued
and the Company has notified the Calculation Agent of such determination (a “EURIBOR Event”), the Calculation
Agent will use, as a substitute for EURIBOR (the “Alternate Rate”) for each future interest determination date,
the alternative reference rate selected by the central bank, reserve bank, monetary authority or any similar institution (including
any committee or working group thereof) that is consistent with market practice regarding a substitute for EURIBOR. As part of
such substitution, the Calculation Agent may make such adjustments to the Alternate Rate or the spread thereon, as well as the
business day convention, Interest Determination Dates and related provisions and definitions, in each case that are consistent
with market practice for the use of such Alternate Rate. If a EURIBOR Event has occurred, but for any reason an Alternate Rate
has not been determined, the rate of EURIBOR for the next Interest Period shall be set equal to the rate of EURIBOR for the then
current Interest Period. All percentages resulting from any of the above calculations shall be rounded, if necessary, to the nearest
one hundred thousandth of a percentage point, with five one-millionths of a percentage point being rounded upwards (e.g., 8.986865%
(or 0.08986865) being rounded to 8.98687% (or 0.0898687)) and all euro amounts used in or resulting from such calculation shall
be rounded to the nearest cent (with one-half cent being rounded upwards). Promptly upon determination, the Calculation Agent shall
inform the Trustee, if applicable, and the Company of the interest rate for the next Interest Period.

 

“Business Day” means
any day, other than a Saturday, Sunday, (i) which is not a day on which banking institutions in New York, New York or London are
authorized or required by law or executive order to close and (ii) on which the Trans European Automated Realtime Gross Settlement
Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

“TARGET System Day” means
any day in which the TARGET2 System, or any successor thereto, is open for business and a day on which commercial banks are open
for dealings in euro deposits in the London interbank market. With respect to notes in certificated form, the reference to business
day shall also mean a day on which banking institutions generally are open for business in the location of each office of a transfer
agent, but only with respect to a payment or other action to occur at that office.

 

The “Calculation
Agent” shall be the agent appointed by the Company to calculate the interest rate on the Securities and shall initially
be the Paying Agent. The Calculation Agent shall calculate the interest rate in accordance with the foregoing. On or before each
Calculation Date (as defined below), the Calculation Agent shall determine the interest rate and notify the Paying Agent. The Calculation
Agent shall, upon the request of any Holder of the Securities, provide the interest rate then in effect with respect to the Securities.
All calculations of the Calculation Agent, in the absence of manifest error, shall be conclusive for all purposes and binding on
the Company, the Trustee and the Holders of this Securities. The “Calculation Date” pertaining to any Interest
Determination Date on the Securities shall be the earlier of (i) the tenth calendar day after such Interest Determination Date,
or, if any such day is not a Business Day, the next succeeding Business Day, and (ii) the Business Day immediately preceding the
applicable Interest Payment Date or the Maturity Date, as the case may be.

 

    	 	A-1-9	 

     

    

 

The interest
rate on this Security shall in no event be higher than the maximum rate permitted by New York law, as the same may be modified
by United States law of general application.

 

Optional Redemption 

 

The Securities of this series may not be
redeemed prior to maturity, except as set forth in Section 4.3 (Redemption for Tax Reasons) of the Supplemental Indenture.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous 

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

    	 	A-1-10	 

     

    

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, shall be issued to the designated transferee or transferees.

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

    	 	A-1-11	 

     

    

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

 

*                                        
*                                        
*

 

    	 	A-1-12	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-1-13	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

 

(Print or type assignee’s name, address and zip code)

 

(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

 

 

Date:  

 

Your Signature*:   

 

By:    

 

Name:    

 

Title:   

 

 

Sign exactly as your name appears on the
other side of this Security.

 

 

*Signature Guaranteed:

 

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-1-14	 

     

    

 

 

FORM
OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈   to the Company; or

 

		(2)	 ̈   pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈   inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈   in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	 ̈   pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

	 	
	 	Signature

 

    	 	A-1-15	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

	Dated:	 	 	Notice:	To be executed by an executive officer

 

    	 	A-1-16	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: Floating Rate Notes due
2020

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

	 	[Insert Name of Transferor]

 

		By:	

		Name:	

		Title:	

 

Dated:
_______________________

 

    	 	A-1-17	 

     

    

 

EXHIBIT A2

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

    	 	A-2-1	 

     

    

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    	 	A-2-2	 

     

    

 

 

ABBVIE INC.

 

0.500% Senior Notes due 2021

 

	No. [●]	€[●]

 

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on June 1, 2021 (the “Maturity Date”), and to pay interest thereon from the most
recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”) on the
0.500% Senior Notes due 2021 issued by Allergan that were accepted in the Exchange Offers, annually on June 1 (the “Interest
Payment Date”), with the first interest payment to be made on June 1, 2020, at the rate of 0.500% per annum, until the
principal and any unpaid and accrued interest are paid or duly provided for.

 

Interest on the Securities shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Securities, but excluding the next following Interest Payment Date. This payment
convention is referred to as ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of the International Capital Market Association).

 

The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is the clearing system
business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments in euro) immediately prior
to the relevant Interest Payment Date (such day, the “Record Date”). For purposes of this Security, “Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the Trans European Automated
Realtime Gross Settlement Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

	1	Rule 144A Note CUSIP:	00287YDE6

	 	Regulation S Note CUSIP:	U0029QBK1

 

	2	Rule 144A Note ISIN:	XS2117754247

	 	Regulation S Note ISIN:	XS2117754163

 

    	 	A-2-3	 

     

    

 

Payments of principal of, and premium, if
any, and interest on, this Security, including payments made upon any redemption of this Security, shall be made by wire transfer
of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange controls or
other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro
is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their currency or
for the settlement of transactions by public institutions or within the international banking community, then all payments in respect
of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such circumstances,
the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal Reserve Board
as of the close of business on the second business day prior to the relevant payment date, or in the event the U.S. Federal Reserve
Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate available on or
prior to the second business day prior to the relevant payment date as determined by the Company in its sole discretion. Any payment
in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default under this Security or the Indenture.
Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any responsibility for any calculation or
conversion in connection with the foregoing.

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    	 	A-2-4	 

     

    

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

Dated:               

 

	 	ABBVIE INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:

 

    	 	A-2-5	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

Dated:             

 

 

	 	 
	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:
	 	 	Authorized Signatory

 

    	 	A-2-6	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”), among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9”), and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Optional Redemption 

 

At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at the Company’s
option, at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal and interest (exclusive of interest
accrued to the Redemption Date) on the Securities of this series to be redeemed discounted to the Redemption Date on an annual
basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 20 basis points.

 

The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.

 

In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date. If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.

 

    	 	A-2-7	 

     

    

 

The Company will give notice of any optional
redemption to and through Euroclear or Clearstream for communication by them to the Holders of interests in the Securities not
more than 60 nor less than 15 days prior to the Redemption Date. The notice of redemption will specify, among other items, the
Redemption Date, redemption price, the principal amount of the Securities of this series to be redeemed and the place or places
that payment will be made upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption
may, at the Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion,
the Redemption Date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two business days prior to the Redemption Date if any such redemption
has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each Holder of Securities in the same
manner in which the notice of redemption was given.

 

The Company will notify the Trustee
at least 30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the Trustee) of
the aggregate principal amount of the Securities of this series to be redeemed and their Redemption Date. If less than all of the
Securities of this series are to be redeemed at any time, the Securities will be selected in accordance with the rules of Euroclear
and Clearstream (to be reflected in the records of Euroclear and Clearstream as either a pool factor or a reduction in nominal
amount, at their discretion).

 

Definitions

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be
Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the Maturity Date, or if such Independent Investment Bank in its discretion determines that such similar
bond is not in issue, such other German government bond as such Independent Investment Bank may, with the advice of three brokers
of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate.

 

“Comparable Government Bond Rate”
means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), on
the third business day prior to the date fixed for redemption, of the Comparable Government Bond on the basis of the middle market
price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business Day as determined by an Independent
Investment Bank.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

 

“Euroclear” means Euroclear
Bank SA/NV.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

    	 	A-2-8	 

     

    

 

“Par Call Date” means
May 1, 2021.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default 

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.

 

    	 	A-2-9	 

     

    

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

*                                        
*                                        
*

 

    	 	A-2-10	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-

Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-

Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-2-11	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

	 
	(Print or type assignee’s name, address and zip code)

 

	 
	(Insert assignee’s soc. sec. or tax I.D. No.)

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

	Date:
	 
	Your Signature*:
	 
	By:
	 
	Name:
	 
	Title:

 

Sign exactly as your name appears on the
other side of this Security.

 

	*Signature Guaranteed:

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-2-12	 

     

    

 

 

FORM OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈    to
the Company; or

 

		(2)	 ̈    pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈    inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈    in an offshore
transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	 ̈    pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

 

	 	 
	 	Signature

 

    	 	A-2-13	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

 

	Dated:____________________	Notice: To be executed by an executive officer

 

    	 	A-2-14	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: 0.500% Senior Notes due
2021

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

 

	 	[Insert
Name of Transferor]
	 	 	 
		By:	
	 	 	Name:
	 	 	Title:

 

Dated: _______________________

 

    	 	A-2-15	 

     

    

 

EXHIBIT A3

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

    	 	A-3-1	 

     

    

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    	 	A-3-2	 

     

    

 

ABBVIE INC.

 

1.500% Senior Notes due 2023

 

	No. [●]	€[●]

 

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on November 15, 2023 (the “Maturity Date”), and to pay interest thereon from the
most recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”) on
the 1.500% Senior Notes due 2023 issued by Allergan that were accepted in the Exchange Offers, annually on November 15 (the “Interest
Payment Date”), with the first interest payment to be made on November 15, 2020, at the rate of 1.500% per annum, until
the principal and any unpaid and accrued interest are paid or duly provided for.

 

Interest on the Securities shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Securities, but excluding the next following Interest Payment Date. This payment
convention is referred to as ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of the International Capital Market Association).

 

The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is the clearing system
business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments in euro) immediately prior
to the relevant Interest Payment Date (such day, the “Record Date”). For purposes of this Security, “Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the Trans European Automated
Realtime Gross Settlement Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

		1	Rule 144A Note CUSIP:	00287YDF3
		 	Regulation S Note CUSIP:	U0029QBL9

 

		2	Rule 144A Note ISIN:	 XS2117754759
		 	Regulation S Note ISIN:	XS2117754593

 

    	 	A-3-3	 

     

    

 

Payments of principal of, and premium, if
any, and interest on, this Security, including payments made upon any redemption of this Security, shall be made by wire transfer
of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange controls or
other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro
is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their currency or
for the settlement of transactions by public institutions or within the international banking community, then all payments in respect
of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such circumstances,
the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal Reserve Board
as of the close of business on the second business day prior to the relevant payment date, or in the event the U.S. Federal Reserve
Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate available on or
prior to the second business day prior to the relevant payment date as determined by the Company in its sole discretion. Any payment
in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default under this Security or the Indenture.
Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any responsibility for any calculation or
conversion in connection with the foregoing.

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    	 	A-3-4	 

     

    

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

	Dated:  
	 
	 
	 	ABBVIE INC.
	 
	 	By:
	 	 	Name:
	 	 	Title:

 

    	 	A-3-5	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

	Dated:  
	 
	 
	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 
	 	By:
	 	 	Authorized Signatory

 

    	 	A-3-6	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”), among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9”), and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Optional Redemption 

 

At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at the Company’s
option, at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal and interest (exclusive of interest
accrued to the Redemption Date) on the Securities of this series to be redeemed discounted to the Redemption Date on an annual
basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 25 basis points.

 

The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.

 

In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date. If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.

 

    	 	A-3-7	 

     

    

 

The Company will give notice of any optional
redemption to and through Euroclear or Clearstream for communication by them to the Holders of interests in the Securities not
more than 60 nor less than 15 days prior to the Redemption Date. The notice of redemption will specify, among other items, the
Redemption Date, redemption price, the principal amount of the Securities of this series to be redeemed and the place or places
that payment will be made upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption
may, at the Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion,
the Redemption Date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two business days prior to the Redemption Date if any such redemption
has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each Holder of Securities in the same
manner in which the notice of redemption was given.

 

The Company will
notify the Trustee at least 30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory
to the Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their Redemption Date. If
less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance with
the rules of Euroclear and Clearstream (to be reflected in the records of Euroclear and Clearstream as either a pool factor or
a reduction in nominal amount, at their discretion).

 

Definitions

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be
Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the Maturity Date, or if such Independent Investment Bank in its discretion determines that such similar
bond is not in issue, such other German government bond as such Independent Investment Bank may, with the advice of three brokers
of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate.

 

“Comparable Government Bond Rate”
means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), on
the third business day prior to the date fixed for redemption, of the Comparable Government Bond on the basis of the middle market
price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business Day as determined by an Independent
Investment Bank.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

 

“Euroclear” means Euroclear
Bank SA/NV.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

    	 	A-3-8	 

     

    

 

“Par Call Date” means
October 15, 2023.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default 

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.

 

    	 	A-3-9	 

     

    

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

	*	* 	 *

 

    	 	A-3-10	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-3-11	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

	(Print or type assignee’s name, address and zip code)

 

	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

Date: 

 

Your Signature*: 

 

By: 

 

Name: 

 

Title: 

 

Sign exactly as your name appears on the
other side of this Security.

 

*Signature Guaranteed: 

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-3-12	 

     

    

 

FORM OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈ to the Company; or

 

		(2)	 ̈ pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈ inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈ in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	 ̈ pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

	 	
	 	Signature

 

    	 	A-3-13	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

	Dated:_____________________	 	Notice: To be executed by an executive officer

 

    	 	A-3-14	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: 1.500% Senior Notes due
2023

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

	 	[Insert Name of Transferor]
	 
	 	By:	                               
	 	 	Name:
	 	 	Title:
	 
	Dated: ______________________

 

    	 	A-3-15	 

     

    

 

EXHIBIT A4

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

    A-4- 1

     

    

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    A-4- 2

     

    

 

ABBVIE INC.

 

1.250% Senior Notes due 2024

 

	No. [●]	€[●]

 

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on June 1, 2024 (the “Maturity Date”), and to pay interest thereon from the most
recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”) on the
1.250% Senior Notes due 2024 issued by Allergan that were accepted in the Exchange Offers, annually on June 1 (the “Interest
Payment Date”), with the first interest payment to be made on June 1, 2020, at the rate of 1.250% per annum, until the
principal and any unpaid and accrued interest are paid or duly provided for.

 

Interest on the Securities shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Securities, but excluding the next following Interest Payment Date. This payment
convention is referred to as ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of the International Capital Market Association).

 

The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is the clearing system
business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments in euro) immediately prior
to the relevant Interest Payment Date (such day, the “Record Date”). For purposes of this Security, “Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the Trans European Automated
Realtime Gross Settlement Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

 

		1	Rule 144A Note CUSIP:	00287YDG1

		 	Regulation S Note CUSIP:	U0029QBM7

 

		2	Rule 144A Note ISIN:	XS2117754916

			Regulation S Note ISIN:	XS2117754833

 

    A-4- 3

     

    

 

Payments of principal of, and premium, if
any, and interest on, this Security, including payments made upon any redemption of this Security, shall be made by wire transfer
of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange controls or
other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro
is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their currency or
for the settlement of transactions by public institutions or within the international banking community, then all payments in respect
of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such circumstances,
the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal Reserve Board
as of the close of business on the second business day prior to the relevant payment date, or in the event the U.S. Federal Reserve
Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate available on or
prior to the second business day prior to the relevant payment date as determined by the Company in its sole discretion. Any payment
in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default under this Security or the Indenture.
Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any responsibility for any calculation or
conversion in connection with the foregoing.

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    A-4- 4

     

    

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

Dated:                 

 

 

	 	ABBVIE INC.
	 	 
	 	By:
	 	 	Name:
	 	 	Title:

 

    	 	A-4-5
	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

Dated:                 

 

 

	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:
	 	 	Authorized Signatory

 

    	 	A-4-6
	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”), among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9”), and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Optional Redemption 

 

At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at the Company’s
option, at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal and interest (exclusive of interest
accrued to the Redemption Date) on the Securities of this series to be redeemed discounted to the Redemption Date on an annual
basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 25 basis points.

 

The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.

 

In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date. If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.

 

The Company will give notice of any optional
redemption to and through Euroclear or Clearstream for communication by them to the Holders of interests in the Securities not
more than 60 nor less than 15 days prior to the Redemption Date. The notice of redemption will specify, among other items, the
Redemption Date, redemption price, the principal amount of the Securities of this series to be redeemed and the place or places
that payment will be made upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption
may, at the Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion,
the Redemption Date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two business days prior to the Redemption Date if any such redemption
has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each Holder of Securities in the same
manner in which the notice of redemption was given.

 

    	 	A-4-7
	 

     

    

 

The Company will
notify the Trustee at least 30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory
to the Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their Redemption Date. If
less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance with
the rules of Euroclear and Clearstream (to be reflected in the records of Euroclear and Clearstream as either a pool factor or
a reduction in nominal amount, at their discretion).

 

Definitions

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be
Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the Maturity Date, or if such Independent Investment Bank in its discretion determines that such similar
bond is not in issue, such other German government bond as such Independent Investment Bank may, with the advice of three brokers
of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate.

 

“Comparable Government Bond Rate”
means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), on
the third business day prior to the date fixed for redemption, of the Comparable Government Bond on the basis of the middle market
price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business Day as determined by an Independent
Investment Bank.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

 

“Euroclear” means
Euroclear Bank SA/NV.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

    	 	A-4-8
	 

     

    

 

“Par Call Date” means
March 1, 2024.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default 

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.

 

    	 	A-4-9
	 

     

    

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

*                                        
*                                        
*

 

    	 	A-4-10
	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-4-11
	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

	 
	(Print or type assignee’s name, address and zip code)

 

	 
	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

 

	Date:	 
	 	 
	Your Signature*:	 
	 	 
	By:	 
	 	 
	Name:	 
	 	 
	Title:	 

 

Sign exactly as your name appears on the
other side of this Security.

 

 

*Signature Guaranteed: 

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-4-12
	 

     

    

 

FORM OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈  to the Company; or

 

		(2)	 ̈  pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈  inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈  in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	 ̈  pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

	 	 
	 	Signature

 

    	 	A-4-13
	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

	Dated:____________________ 	Notice: To be executed by an executive officer

 

    	 	A-4-14
	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: 1.250% Senior Notes due
2024

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

	 	[Insert Name of Transferor]
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:

 

Dated: _______________________

 

    	 	A-4-15
	 

     

    

 

EXHIBIT A5

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

    	 	A-5-1
	 

     

    

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    	 	A-5-2
	 

     

    

 

ABBVIE INC.

 

2.625% Senior Notes due 2028

 

	No. [●]	€[●]

 

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on November 15, 2028 (the “Maturity Date”), and to pay interest thereon from the
most recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”) on
the 2.625% Senior Notes due 2028 issued by Allergan that were accepted in the Exchange Offers, annually on November 15 (the
 “Interest Payment Date”), with the first interest payment to be made on November 15, 2020, at the rate of 2.625%
per annum, until the principal and any unpaid and accrued interest are paid or duly provided for.

 

Interest on the Securities shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Securities, but excluding the next following Interest Payment Date. This payment
convention is referred to as ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of the International Capital Market Association).

 

The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is the clearing system
business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments in euro) immediately prior
to the relevant Interest Payment Date (such day, the “Record Date”). For purposes of this Security, “Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the Trans European Automated
Realtime Gross Settlement Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

 

		1	Rule 144A Note CUSIP:	00287YDH9

			Regulation S Note CUSIP:	U0029QBN5

 

		2	Rule 144A Note ISIN:	XS2117755210
	 	 	Regulation S Note ISIN:	XS2117755053

 

    	 	A-5-3
	 

     

    

 

Payments of principal of, and premium, if
any, and interest on, this Security, including payments made upon any redemption of this Security, shall be made by wire transfer
of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange controls or
other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro
is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their currency or
for the settlement of transactions by public institutions or within the international banking community, then all payments in respect
of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such circumstances,
the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal Reserve Board
as of the close of business on the second business day prior to the relevant payment date, or in the event the U.S. Federal Reserve
Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate available on or
prior to the second business day prior to the relevant payment date as determined by the Company in its sole discretion. Any payment
in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default under this Security or the Indenture.
Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any responsibility for any calculation or
conversion in connection with the foregoing.

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    	 	A-5-4
	 

     

    

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

Dated:              

 

 

	 	ABBVIE INC.
	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:

 

    	 	A-5-5
	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

Dated:              

 

 

	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:
	 	 	Authorized Signatory

 

    	 	A-5-6
	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”), among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9”), and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Optional Redemption 

 

At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at the Company’s
option, at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal and interest (exclusive of interest
accrued to the Redemption Date) on the Securities of this series to be redeemed discounted to the Redemption Date on an annual
basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 35 basis points.

 

The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.

 

In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date. If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.

 

The Company will give notice of any optional
redemption to and through Euroclear or Clearstream for communication by them to the Holders of interests in the Securities not
more than 60 nor less than 15 days prior to the Redemption Date. The notice of redemption will specify, among other items, the
Redemption Date, redemption price, the principal amount of the Securities of this series to be redeemed and the place or places
that payment will be made upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption
may, at the Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion,
the Redemption Date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two business days prior to the Redemption Date if any such redemption
has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each Holder of Securities in the same
manner in which the notice of redemption was given.

 

    	 	A-5-7
	 

     

    

 

The Company will
notify the Trustee at least 30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory
to the Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their Redemption Date. If
less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance with
the rules of Euroclear and Clearstream (to be reflected in the records of Euroclear and Clearstream as either a pool factor or
a reduction in nominal amount, at their discretion).

 

Definitions

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be
Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the Maturity Date, or if such Independent Investment Bank in its discretion determines that such similar
bond is not in issue, such other German government bond as such Independent Investment Bank may, with the advice of three brokers
of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate.

 

“Comparable Government Bond Rate”
means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), on
the third business day prior to the date fixed for redemption, of the Comparable Government Bond on the basis of the middle market
price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business Day as determined by an Independent
Investment Bank.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

 

“Euroclear” means Euroclear
Bank SA/NV.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

    	 	A-5-8
	 

     

    

 

“Par Call Date” means
August 15, 2028.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default 

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.

 

    	 	A-5-9
	 

     

    

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

*                                        
*                                        
*

 

    	 	A-5-10
	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-5-11
	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

	 
	(Print or type assignee’s name, address and zip code)

 

	 
	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

 

	Date:	 
	 	 
	Your Signature*:	 
	 	 
	By:	 
	 	 
	Name:	 
	 	 
	Title:	 

 

Sign exactly as your name appears on the
other side of this Security.

 

*Signature Guaranteed: 

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”) or such
other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-5-12
	 

     

    

 

FORM OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈ to the Company; or

 

		(2)	 ̈ pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈ inside the United States to a person reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈ in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	  ̈ pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

	 	 
		
	 	Signature

 

    	 	A-5-13
	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

		Dated:________________________	Notice: To be executed by an executive officer

 

    	 	A-5-14
	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: 2.625% Senior Notes due
2028

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

	 	[Insert Name of Transferor]
	 
	 	By:	______________________
	 	 	Name:
	 	 	Title:
	 
	Dated: _______________________

 

    	 	A-5-15
	 

     

    

 

EXHIBIT A6

 

(FORM OF FACE OF INITIAL NOTE)

 

THIS SECURITY IS A SECURITY IN A GLOBAL FORM WITHIN THE MEANING
OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF USB NOMINEES (UK) LIMITED, AS NOMINEE OF ELAVON FINANCIAL
SERVICES DAC, AS COMMON DEPOSITARY (THE “COMMON DEPOSITARY”) FOR EUROCLEAR BANK SA/NV (“EUROCLEAR”) AND
CLEARSTREAM BANKING S.A. (“CLEARSTREAM”), UNLESS AND UNTIL THIS SECURITY IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES
IN DEFINITIVE, CERTIFICATED FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE COMMON DEPOSITARY TO A NOMINEE
THEREOF OR BY A NOMINEE THEREOF TO THE COMMON DEPOSITARY OR ANOTHER NOMINEE OF THE COMMON DEPOSITARY OR BY THE COMMON DEPOSITARY
OR A NOMINEE OF THE COMMON DEPOSITARY TO A SUCCESSOR COMMON DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR COMMON DEPOSITARY. THIS GLOBAL
SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE NOMINEE OF THE COMMON DEPOSITARY ONLY
IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS SECURITY
AS A WHOLE AS DESCRIBED ABOVE) MAY BE REGISTERED EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION.

 

NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN
MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION
OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE
HEREOF, AGREES ON ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ISSUE DATE HEREOF OR ANY OTHER
ISSUE DATE IN RESPECT OF A FURTHER ISSUANCE OF SECURITIES OF THE SAME SERIES AND THE LAST DATE ON WHICH ABBVIE INC. OR ANY AFFILIATE
OF ABBVIE INC. WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF SUCH SECURITY), ONLY (A) TO ABBVIE INC. OR ANY SUBSIDIARY
THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR
SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT (“RULE 144A”),
TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A
THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER
IS BEING MADE IN RELIANCE ON RULE 144A IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (D) PURSUANT TO OFFERS
AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES
ACT, (E) TO AN INSTITUTIONAL “ACCREDITED INVESTOR” WITHIN THE MEANING OF RULE 501(a)(1), (2), (3) OR (7)
UNDER THE SECURITIES ACT THAT IS NOT A QUALIFIED INSTITUTIONAL BUYER AND THAT IS PURCHASING FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT
OF ANOTHER INSTITUTIONAL ACCREDITED INVESTOR, IN EACH CASE IN A MINIMUM PRINCIPAL AMOUNT OF THE SECURITIES OF $250,000, FOR INVESTMENT
PURPOSES AND NOT WITH A VIEW TO OR FOR OFFER OR SALE IN CONNECTION WITH ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT OR
(F) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO ABBVIE INC.’S
AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D), (E) OR (F) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE.

 

    	 	A-6-1
	 

     

    

 

[EACH PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE
SELLER OF THIS SECURITY MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE SECURITIES ACT PROVIDED BY
RULE 144A THEREUNDER.](1)

 

[BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT
IT IS NOT A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION
IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.](2)

 

(1) Applies to Rule 144A Notes only

 

(2) Applies to Regulation S Notes only

 

    	 	A-6-2
	 

     

    

 

ABBVIE INC.

 

2.125% Senior Notes due 2029

 

	No. [●]	€[●]

CUSIP No: [●]1

 

ISIN No: [●]2

 

ABBVIE INC., a corporation duly organized
and existing under the laws of Delaware (herein called the “Company,” which term includes any successor Person
under the Indenture and Supplemental Indenture hereinafter referred to), for value received, hereby promises to pay to USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common Depositary”) for
Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”), or registered
assigns, the principal sum of [●] euro (€[●]), or such other principal sum as may be indicated on the Schedule
of Exchanges attached hereto, on June 1, 2029 (the “Maturity Date”), and to pay interest thereon from the most
recent date on which interest has been paid or duly provided for by Allergan Funding SCS (“Allergan”) on the
2.125% Senior Notes due 2029 issued by Allergan that were accepted in the Exchange Offers, annually on June 1 (the “Interest
Payment Date”), with the first interest payment to be made on June 1, 2020, at the rate of 2.125% per annum, until the
principal and any unpaid and accrued interest are paid or duly provided for.

 

Interest on the Securities shall be determined
on the basis of the actual number of days in the period for which interest is being calculated, and including the last date on
which interest was paid or duly provided for on the Securities, but excluding the next following Interest Payment Date. This payment
convention is referred to as ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of the International Capital Market Association).

 

The interest so payable, and punctually
paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is the clearing system
business day (which, for these purposes, is a day on which Euroclear and Clearstream settle payments in euro) immediately prior
to the relevant Interest Payment Date (such day, the “Record Date”). For purposes of this Security, “Business
Day” means any day, other than a Saturday or Sunday, (i) which is not a day on which banking institutions in New York,
New York or London are authorized or required by law or executive order to close and (ii) on which the Trans European Automated
Realtime Gross Settlement Express Transfer System, or the TARGET2 System, or any successor thereto, operates.

 

 

		1	Rule 144A Note CUSIP:	00287YDJ5
		 	Regulation S Note CUSIP:	U0029QBP0

 

		2	Rule 144A Note ISIN:	XS2117755996
		 	Regulation S Note ISIN:	XS2117755566

 

    	 	A-6-3
	 

     

    

 

Payments of principal of, and premium,
if any, and interest on, this Security, including payments made upon any redemption of this Security, shall be made by wire transfer
of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange controls or
other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or if the euro
is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their currency
or for the settlement of transactions by public institutions or within the international banking community, then all payments
in respect of this Security shall be made in U.S. Dollars until the euro is again available to the Company or so used. In such
circumstances, the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S. Federal
Reserve Board as of the close of business on the second business day prior to the relevant payment date, or in the event the U.S.
Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange rate
available on or prior to the second business day prior to the relevant payment date as determined by the Company in its sole discretion.
Any payment in respect of this Security so made in U.S. Dollars shall not constitute an Event of Default under this Security or
the Indenture. Neither the Trustee nor the Paying Agent (as defined on the reverse hereof) shall have any responsibility for any
calculation or conversion in connection with the foregoing.

 

Reference is hereby made to the further
provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect
as if set forth at this place.

 

Unless the certificate of authentication
hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purpose.

 

    	 	A-6-4
	 

     

    

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

	Dated:             
	 
	 
	 	ABBVIE INC.
	 
	 	By:
	 	 	Name:
	 	 	Title:

 

    	 	A-6-5
	 

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the Securities of the series
designated therein referred to in the within-mentioned Indenture.

 

	Dated:                
	 
	 
	 	U.S. BANK NATIONAL ASSOCIATION,
	 	 	as Trustee
	 	 
	 	By:
	 	 	Authorized Signatory

 

    	 	A-6-6
	 

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one of a duly authorized
issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more
series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended from time to time (herein called
the “Base Indenture”), between the Company and U.S. Bank National Association, as Trustee (herein called the
 “Trustee,” which term includes any successor trustee under the Indenture), and Supplemental Indenture No. 9,
dated as of May 14, 2020 (herein called the “Supplemental Indenture”), among the Company, the Trustee, Elavon
Financial Services DAC, U.K. Branch, as paying agent (the “Paying Agent”), and U.S. Bank National Association,
as transfer agent and registrar (the “Transfer Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 9”), and together with the Base Indenture, the “Indenture”), to which Indenture,
Supplemental Indenture and all supplemental indentures thereto reference is hereby made for a statement of the respective rights,
limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series
and of the terms upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one
of the series designated on the face hereof, in an initial aggregate principal amount of €[●].

 

Optional Redemption 

 

At any time prior to the Par Call Date (as
defined below), the Company may redeem some or all of the Securities of this series at its option, in each case at the Company’s
option, at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal and interest (exclusive of interest
accrued to the Redemption Date) on the Securities of this series to be redeemed discounted to the Redemption Date on an annual
basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 30 basis points.

 

The Company will pay accrued and unpaid
interest on the principal amount of the Securities of this series being redeemed to, but excluding, the Redemption Date.

 

In addition, at any time on or after the
Par Call Date, the Company may redeem some or all of the Securities of this series at its option at a redemption price equal to
100% of the principal amount of the Securities of this series to be redeemed, plus accrued and unpaid interest on the principal
amount of Securities of this series being redeemed to, but excluding, the Redemption Date. If the Company has given notice as provided
in the Indenture and funds for the redemption of any Securities of this series called for redemption have been made available on
the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the date fixed for redemption.
Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption price.

 

    	 	A-6-7
	 

     

    

 

The Company will give notice of any optional
redemption to and through Euroclear or Clearstream for communication by them to the Holders of interests in the Securities not
more than 60 nor less than 15 days prior to the Redemption Date. The notice of redemption will specify, among other items, the
Redemption Date, redemption price, the principal amount of the Securities of this series to be redeemed and the place or places
that payment will be made upon surrender of the Securities of this series to be redeemed. Any redemption or notice of redemption
may, at the Company’s discretion, be subject to one or more conditions precedent, and, at the Company’s discretion,
the Redemption Date may be delayed until such time as any or all such conditions shall be satisfied. The Company shall provide
written notice to the Trustee prior to the close of business two business days prior to the Redemption Date if any such redemption
has been rescinded or delayed, and upon receipt the Trustee shall provide such notice to each Holder of Securities in the same
manner in which the notice of redemption was given.

 

The Company will
notify the Trustee at least 30 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory
to the Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their Redemption Date. If
less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance with
the rules of Euroclear and Clearstream (to be reflected in the records of Euroclear and Clearstream as either a pool factor or
a reduction in nominal amount, at their discretion).

 

Definitions

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, which initially shall be
Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an Independent
Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German government bond”),
whose maturity is closest to the Maturity Date, or if such Independent Investment Bank in its discretion determines that such similar
bond is not in issue, such other German government bond as such Independent Investment Bank may, with the advice of three brokers
of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate.

 

“Comparable Government Bond Rate”
means the yield to maturity, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), on
the third business day prior to the date fixed for redemption, of the Comparable Government Bond on the basis of the middle market
price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business Day as determined by an Independent
Investment Bank.

 

“Definitive Note” means
a certificated Note that does not include the Global Notes Legend.

 

“euro” or “€”
means the currency of the member states of the European Monetary Union that have adopted or that adopt the single currency in accordance
with the treaty establishing the European Community, as amended by the Treaty on European Union.

“Euroclear” means Euroclear
Bank SA/NV.

 

“Independent Investment Bank”
means an independent investment bank selected by the Company.

 

    	 	A-6-8
	 

     

    

 

“Par Call Date” means
March 1, 2029.

 

“U.S. Dollar” or “$”
means the lawful currency of the United States of America.

 

Sinking Fund 

 

The Securities of this series do not provide
for a sinking fund.

 

Default 

 

If an Event of Default with respect to Securities
of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in
the manner and with the effect provided in the Indenture.

 

Miscellaneous

 

The Indenture contains provisions for defeasance
at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to
this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and 13.3 of the Indenture
apply to the Securities of this series.

 

The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of
the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with
the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding of each series
to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the
Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive compliance
by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders
of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof,
whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein to the Indenture or
Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security
at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the Indenture and subject
to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender
of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any
premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form
satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate
principal amount, will be issued to the designated transferee or transferees.

 

    	 	A-6-9
	 

     

    

 

The Securities of this series are issuable
in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in excess thereof. As
provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for
a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination, as requested
by the Holder surrendering the same.

 

No service charge shall be made for any
registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require payment of a sum sufficient
to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith (other than any such transfer
taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Section 9.6 or 11.7 of the Indenture).

 

Prior to due presentment of this Security
for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat the Person in whose
name this Security is registered as the owner hereof for the purpose of receiving payments and for all other purposes, whether
or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

 

All terms used in this Security that are
not defined herein but which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in
the Indenture and Supplemental Indenture.

 

THIS SECURITY SHALL BE GOVERNED BY AND CONSTRUED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a Book-Entry Security within
the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for Euroclear and Clearstream. This Security is exchangeable for Securities registered in the name of a Person
other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture and may not be transferred
except as a whole by the Common Depositary to a nominee of the Common Depositary or by a nominee of the Common Depositary to the
Common Depositary or another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary
to a successor Common Depositary or a nominee of such successor Common Depositary.

 

	*	* 	*

 

    	 	A-6-10
	 

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges, redemptions or
purchases of a part of this Book-Entry Security have been made:

 

	Date of

Exchange/

Redemption/

Repurchase	Amount of

decrease in

Principal Amount

of this Book-Entry

Security	Amount of

increase in

Principal Amount

of this Book-

Entry Security	Principal Amount

of this Book-Entry

Security following

such decrease (or

increase)	Signature of

authorized

signatory of

Trustee
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

 

    	 	A-6-11
	 

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form below:

 

I or we assign and transfer this Security to

 

 

	(Print or type assignee’s name, address and zip code)

 

 

	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint                               
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

Date: 

 

Your Signature*: 

 

By: 

 

Name: 

 

Title: 

 

Sign exactly as your name appears on the
other side of this Security.

 

*Signature Guaranteed:

 

*NOTICE: The signature to this assignment must correspond with
the name as it appears upon the face of the within Note in every particular, without alteration, enlargement or any change whatever.
Such signature must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security
Registrar, which requirements include membership or participation in Security Transfer Agents Medallion Program (“STAMP”)
or such other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution
for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

 

    	 	A-6-12
	 

     

    

 

FORM OF TRANSFER CERTIFICATE

 

In connection with any transfer of any of
the Securities evidenced by this certificate occurring prior to the expiration of the period referred to in Rule 144 under
the Securities Act (“Rule 144”) after the later of the date of original issuance of such Notes and the last date,
if any, on which such Notes were owned by the Company or any Affiliate (as such term is defined in Rule 144) of the Company,
the undersigned confirms that such Securities are being transferred in accordance with its terms:

 

CHECK
ONE BOX BELOW

 

		(1)	 ̈ to the Company; or

 

		(2)	 ̈ pursuant to an effective registration statement under the Securities Act; or

 

		(3)	 ̈ inside the United States to a Form reasonably believed to be a “qualified institutional buyer” (as
defined in Rule 144A under the Securities Act) that purchases for its own account or for the account of a qualified institutional
buyer to whom notice is given that such transfer is being made in reliance on Rule 144A, in each case pursuant to and in compliance
with Rule 144A under the Securities Act; or

 

		(4)	 ̈ in an offshore transaction in compliance with Rule 903 or Rule 904 of Regulation S under the Securities Act; or

 

		(5)	 ̈ pursuant to the exemption from registration provided by Rule 144 under the Securities Act or any other available
exemption from the registration requirement of the Securities Act.

 

Unless one of the boxes is checked,
the Trustee shall refuse to register any of the Securities evidenced by this certificate in the name of any person other than the
registered holder thereof; provided, however, that if box (5) is checked, the Trustee shall be entitled to require,
prior to registering any such transfer of the Securities, such legal opinions, certifications and other information as the Company
has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or in a transaction not subject
to, the registration requirements of the Securities Act.

 

	 	
	 	Signature

 

    	 	A-6-13
	 

     

    

 

TO BE COMPLETED
BY PURCHASER IF (3) ABOVE IS CHECKED.

 

The undersigned represents and warrants that it is purchasing
this Security for its own account or an account with respect to which it exercises sole investment discretion and that it and any
such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act, and is
aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding
the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it
is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption
from registration provided by Rule 144A.

 

	Dated:____________________ 	Notice: To be executed by an executive officer

 

    	 	A-6-14
	 

     

    

 

FORM OF EXCHANGE CERTIFICATE

 

AbbVie Inc.

1 North Waukegan Road

North Chicago, Illinois 60064

 

U.S. Bank National Association

190 South LaSalle Street, 10th Floor

Chicago, IL 60603

Attention: Corporate Trust Services

 

Re: 2.125% Senior Notes due
2029

 

Reference is hereby made to the Indenture,
dated as of November 8, 2012 (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated as
of November 8, 2012, the Second Supplemental Indenture, dated as of May 14, 2015, the Third Supplemental Indenture, dated as of
May 12, 2016, the Fourth Supplemental Indenture, dated as of November 17, 2016, the Fifth Supplemental Indenture, dated as of September
18, 2018, the Sixth Supplemental Indenture, dated as of September 26, 2019, the Seventh Supplemental Indenture, dated as of November
21, 2019, the Eighth Supplemental Indenture, dated as of May 14, 2020, and the Ninth Supplemental Indenture, dated as of May 14,
2020 (as so supplemented, the “Indenture”), between AbbVie Inc. (the “Company”) and U.S. Bank National
Association, a national banking association, as trustee. Capitalized terms used but not defined herein shall have the meanings
given to them in the Indenture.

 

___________ (the “Owner”) owns
and proposes to exchange the Security[ies] or interest in such Security[ies] specified herein, in the principal amount of €__________
in such Security[ies] or interests (the “Exchange”). In connection with the Exchange, the Owner hereby certifies that
in connection with the Exchange of the Owner’s Regulation S Global Note for a beneficial interest in the Rule 144A Global
Note, with an equal principal amount, the Security[ies] or interest in such Security[ies] specified herein [is][are] being transferred
to a Person (A) who the transferor reasonably believes to be a QIB, (B) purchasing for its own account or the account of a QIB
in a transaction meeting the requirements of Rule 144A, and (C) in accordance with all applicable securities laws of the States
of the United States and other jurisdictions.

 

This certificate and the statements contained
herein are made for your benefit and the benefit of the Company and are dated ______________________.

 

[Insert
Name of Transferor]

 

		By:	

		Name:	

		Title:	

 

Dated: _______________________

 

    	 	A-6-15
	 

     

    

 

EXHIBIT B

 

FORM OF CERTIFICATE TO BE

DELIVERED IN CONNECTION WITH

TRANSFERS PURSUANT TO REGULATION S

 

[Date]

 

Attention:

 

		Re:	

 

AbbVie Inc. (the “Company”)

[applicable series of Notes] (the “Securities”)

 

Ladies and Gentlemen:

 

In connection with our proposed sale of €______________
aggregate principal amount of the Securities, we confirm that such sale has been effected pursuant to and in accordance with Regulation S
under the U.S. Securities Act of 1933, as amended (the “Securities Act”), and, accordingly, we represent that:

 

		(1)	the offer of the Securities was not made to a person in the United States;

 

		(2)	either (a) at the time the buy offer was originated, the transferee was outside the United States or we and any person acting
on our behalf reasonably believed that the transferee was outside the United States, or (b) the transaction was executed in, on
or through the facilities of a designated offshore securities market and neither we nor any person acting on our behalf knows that
the transaction has been prearranged with a buyer in the United States;

 

		(3)	no directed selling efforts have been made in the United States in contravention of the requirements of Rule 903 or Rule 904
of Regulation S, as applicable;

 

		(4)	the transaction is not part of a plan or scheme to evade the registration requirements of the Securities Act; and

 

		(5)	we have advised the transferee of the transfer restrictions applicable to the Securities.

 

You and the Company are entitled to rely upon this letter and
are irrevocably authorized to produce this letter or a copy hereof to any interested party in any administrative or legal proceedings
or official inquiry with respect to the matters covered hereby. Terms used in this certificate have the meanings set forth in Regulation S.

 

    B-1

     

    

 

	 	Very truly yours,
	 
	 	[Name of Transferor]
	 
	 	By:	            
	 
	 	Authorized Signature

 

    B-2Exhibit 4.16

 

Dated
May 14, 2020

 

 

ISSUER

 

PAYING AGENT

 

TRANSFER AGENT

 

REGISTRAR

 

CALCULATION AGENT

 

- AND-

 

TRUSTEE

 

 

AGENCY AGREEMENT

 

    

     

    

 

CONTENTS

 

	CLAUSE	 	PAGE

 

	1.	Interpretation	4
	2.	Appointment of the Registrar	4
	3.	Appointment of the Transfer Agent	4
	4.       	Appointment
                                         of Paying Agent	5
	5.       	Appointment
                                         of Calculation Agent	5
	6.	Authentication and Delivery of Notes	5
	7.	Payment	6
	8.	Computation of Interest	6
	9.	Repayment	7
	10.	Prepayment; Notice of Withholding or Deduction	7
	11.	Issue of Replacement Notes	8
	12.	Records	8
	13.	Fees And Expenses	8
	14.	Indemnity	9
	15.	Conditions of Appointment	9
	16.	Changes in Paying Agent Calculation Agent, Transfer Agent or Registrar and Specified Offices	11
	17.	Notices	12
	18.	Communications	13
	19.	Amendments	14
	20.	Taxes	15
	21.	Regulatory Matters	15
	22.	Governing Law and Jurisdiction; Waiver of Jury Trial; Service of Process	16
	23.	Counterparts	17
	24.	Severability	17
	25.	Benefit of Agreement	17

	APPENDIX 1	19

 

    

     

    

 

THIS AGREEMENT (this “Agreement”)
is made on May 14, 2020

 

BETWEEN:

 

		(1)	ABBVIE INC., a Delaware corporation, registered number 32-0375147, with its registered office at
1 North Waukegan Road, North Chicago, Illinois 60064, USA (the “Issuer”);

 

		(2)	ELAVON FINANCIAL SERVICES DAC, a designated activity company registered in Ireland with the Companies
Registration Office, registered number 418442, with its registered office at 2nd Floor, Block E, Cherrywood Science &
Technology Park, Loughlinstown, Co. Dublin, Ireland, acting through its UK Branch (registered number BR009373) from its
offices at 125 Old Broad Street, Fifth Floor, London EC2N 1AR under the trade name U.S. Bank Global Corporate Trust Services, as
Paying Agent (the “Paying Agent” which expression shall include any successor paying agent appointed in accordance
with this Agreement);

 

		(3)	ELAVON FINANCIAL SERVICES DAC, a designated activity company registered in Ireland with the Companies
Registration Office, registered number 418442, with its registered office at 2nd Floor, Block E, Cherrywood Science &
Technology Park, Loughlinstown, Co. Dublin, Ireland, acting through its UK Branch (registered number BR009373) from its
offices at 125 Old Broad Street, Fifth Floor, London EC2N 1AR under the trade name U.S. Bank Global Corporate Trust Services, as
Calculation Agent (the “Calculation Agent” which expression shall include any successor calculation agent appointed
in accordance with this Agreement);

 

		(4)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York, as Transfer Agent (the “Transfer
Agent” which expression shall include any successor transfer agent appointed in accordance with this Agreement);

 

		(5)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York, as Registrar (the “Registrar”
which expression shall include any successor registrar appointed in accordance with this Agreement, and together with the Paying
Agent, the Calculation Agent and the Transfer Agent, the “Agents” and each an “Agent”); and

 

		(6)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York, as Trustee (the “Trustee”).

 

WHEREAS:

 

		(A)	The Issuer has agreed to issue Floating Rate Notes due 2020 (the “Floating Rate Notes”),
0.500% Senior Notes due 2021 (the “2021 Notes”), 1.500% Senior Notes due 2023 (the “2023 Notes”),
1.250% Senior Notes due 2024 (the “2024 Notes”), 2.625% Senior Notes due 2028 (the “2028 Notes”)
and 2.125% Senior Notes due 2029 (the “2029 Notes” and, together with the 2028 Notes, the 2024 Notes, the 2023
Notes, the 2021 Notes and the Floating Rate Notes, the “Notes”). The Notes will initially be represented by
one or more global notes in registered form (the “Global Notes”).

 

    

     

    

 

		(B)	The Notes are to be constituted by an indenture dated November 8, 2012 (the “Base
Indenture”), as supplemented by the Supplemental Indenture No. 9 dated May 14, 2020 (the “Supplemental
Indenture,” and together with the Base Indenture, the “Indenture”), as set out in Appendix 1.

 

		(C)	The Issuer hereby appoints the Paying Agent, the Calculation Agent, the Transfer Agent and the
Registrar in accordance with the terms of this Agreement and the Indenture.

 

IT IS AGREED:

 

		1.	Interpretation

 

		1.1	Unless the context otherwise requires:

 

		1.2	References in this Agreement to the payment of principal or interest in respect of any Note shall
be deemed to include any additional amounts which may become payable in respect thereof pursuant to the Notes and the Indenture.

 

		1.3	All references in this Agreement to an agreement, instrument or other document (including this
Agreement, the Indenture and the Notes) shall be construed as a reference to that agreement, instrument or document as the same
may be amended, modified, varied, supplemented or novated from time to time.

 

		1.4	Except as specifically set forth in this Agreement, this Agreement is for the exclusive benefit
of the parties to this Agreement and their respective permitted successors, and shall not be deemed to give, either expressly or
implicitly, any legal or equitable right, remedy, or claim to any other entity or person whatsoever.

 

		2.	Appointment of the Registrar

 

		2.1	The Issuer hereby appoints the Registrar, and the Registrar hereby agrees to act at its specified
office as registrar in relation to the Notes in accordance with the provisions of this Agreement and the Indenture and upon the
terms and subject to the conditions contained in this Agreement and the Indenture.

 

		2.2	On the date of this Agreement, the Registrar shall provide to the Paying Agent a complete and correct
copy of the register maintained by the Registrar in respect of the holders of Notes and the outstanding principal amount of Notes
held by each holder of Notes.

 

		2.3	The Registrar shall from time to time provide to the Paying Agent a complete and correct copy of
the register of Notes maintained by it as soon as reasonably practicable following any transfer or exchange of any Notes, and promptly
on request therefor by the Paying Agent.

 

		2.4	The Paying Agent shall be entitled to treat as conclusive the most recent copy of the register
provided to it by the Registrar in accordance with this Agreement.

 

		3.	Appointment of the Transfer Agent

 

		3.1	The Transfer Agent is hereby appointed as the agent of the Issuer, to act as Transfer Agent for
the purposes specified in this Agreement, the Indenture and the Notes, including, inter alia, completing, authenticating, holding
and delivering Notes, upon the terms and subject to the conditions specified herein, the Indenture and in the Notes, and the Transfer
Agent hereby accepts such appointment.

 

    4

     

    

 

		4.	Appointment of Paying Agent

 

		4.1	The Issuer hereby appoints the Paying Agent, and the Paying Agent hereby agrees, to act at its
specified office as paying agent in relation to the Notes in accordance with the provisions of this Agreement and the Indenture
and upon the terms and subject to the conditions contained in this Agreement and the Indenture.

 

		4.2	The Paying Agent is appointed hereunder for the purposes of:

 

		(a)	paying sums due on the Notes referred to in the Supplemental Indenture; and

 

		(b)	otherwise fulfilling its duties and obligations as set out in this Agreement and the Indenture.

 

		5.	Appointment of Calculation Agent

 

		(a)	The Issuer hereby appoints the Calculation Agent, and the Calculation Agent hereby agrees, to act
at its specified office as calculation agent in relation to the Floating Rate Notes in accordance with the provisions of this Agreement
and the Indenture and upon the terms and subject to the conditions contained in this Agreement, the Indenture and the Floating
Rate Notes. For the avoidance of doubt, this appointment shall apply only to the Floating Rate Notes issued as of the date hereof,
unless otherwise specifically agreed in writing by the Calculation Agent.

 

		(b)	The Calculation Agent is appointed hereunder for the purposes of calculating the interest rate
on the Floating Rate Notes in accordance with Section 8 of this Agreement.

 

		6.	Authentication and Delivery of Notes

 

		6.1	If a Global Note is to be exchanged in accordance with its terms for definitive notes, the Issuer
undertakes that it will deliver to, or to the order of, the Paying Agent, as soon as reasonably practicable and in any event not
later than 15 days before the relevant exchange is due to take place, definitive Notes in an aggregate principal amount of €3,064,769,000
or such lesser amount as is the principal amount of Notes represented by the Global Note to be issued in exchange for the Global
Note. Each definitive Note so delivered shall be duly executed on behalf of the Issuer.

 

		6.2	The Issuer authorises and instructs the Trustee to authenticate the Global Notes and any definitive
notes delivered pursuant to subclause 6.1 subject to and in accordance with Section 3.3 of the Indenture.

 

		6.3	The Issuer authorises and instructs the Paying Agent to cause interests in a Global Note to be
exchanged for definitive notes in accordance with their respective terms. Following the exchange of the last interest in a Global
Note, the Paying Agent shall deliver the relevant Global Note to the Trustee for cancellation in accordance with Section 3.9
of the Indenture.

 

    5

     

    

 

		7.	Payment

 

Subject always to the Indenture
and, in particular, any restrictions on the Issuer following delivery of a notice of an Event of Default (as defined in the Indenture):

 

		(a)	The Issuer shall, not later than 2.00 p.m. (London time) on a day which is one Business Day
prior to the Business Day on which any payment in respect of the Notes becomes due, pay to such account of the Paying Agent as
the Paying Agent shall specify in Euros in immediately available funds on each due date for the payment of principal and/or interest
and/or other amounts referred to in Section 3.1 of the Indenture in respect of the Notes, an amount sufficient (together with
any funds then held by the Paying Agent and available for the purpose) to pay all principal and interest and/or other amounts referred
to in Section 3.1 of the Indenture due in respect of the Notes on such date; ; provided that if any such date is not a Business
Day such payment shall be made on the next succeeding date which is a Business Day. As used in this Agreement, “Business
Day” shall have the meaning as set forth in the Notes.

 

		(b)	The Issuer hereby authorises and directs the Paying Agent from funds so paid to the Paying Agent
to make payment of all amounts due on the Notes in accordance with the terms of the Notes, the Indenture and the provisions of
this Agreement. If any payment provided for in clause 7(a) is made late but otherwise in accordance with the provisions of
this Agreement, the Paying Agent shall nevertheless make payments in respect of the Notes as aforesaid following receipt by the
Paying Agent of such payment.

 

		(c)	If the Paying Agent has not, on the date on which any payment is due to be made to the Paying Agent
pursuant to clause 7(a), received the full amount payable in respect thereof on such date but receives such full amount later,
together with accrued interest (if any) in accordance with the Indenture, it shall forthwith so notify the Issuer and the Trustee.
Unless and until the full amount of any such principal or interest payment has been made to it, the Paying Agent will not be bound
to make such payments.

 

		(d)	Without prejudice to clause 7(b), if the Paying Agent pays out on or after the due date therefor
to persons entitled thereto, or becomes liable to pay out, any amounts on the assumption (which is not negated by reasonable evidence
to the contrary) that the corresponding payment by the Issuer has been or will be made, the Issuer shall on demand reimburse the
Paying Agent for the relevant amount, and pay interest to the Paying Agent on such amount from (and including) the date on which
it is paid out to (but excluding) the date of reimbursement at the rate per annum equal to the cost to the Paying Agent of funding
the amount paid out, as certified by the Paying Agent and expressed as a rate per annum.

 

		(e)	Payment of only part of the amount payable in respect of a Note may only be made at the discretion
of the relevant Noteholder(s) (except as the result of a withholding or deduction for or on account of any taxes permitted
by the Indenture). If at any time a Paying Agent makes a partial payment in respect of any Note presented to it, it shall inform
the Registrar of the same such that the Registrar may record the same on the register of Notes.

 

		8.	Computation of Interest

 

		(a)	The Calculation Agent shall, as soon as practicable after 11:00 a.m. (Brussels time) on each
date which is two TARGET System Days (as defined in the Floating Rate Notes) before the initial interest period and each subsequent
interest period, calculate the interest rate on the Floating Rate Notes for the following interest period in accordance with the
terms contained within the Floating Rate Notes. The determination of the interest rate by the Calculation Agent shall, in the absence
of manifest error, be final and binding on all parties. In no event will the interest rate on the Floating Rate Notes be less than
0.00% or higher than the maximum rate permitted by applicable law, provided, however, that the Calculation Agent shall not be responsible
for verifying that the rate of interest on the Floating Rate Notes is permitted under any applicable law. Promptly upon such determination,
the Calculation Agent will notify the Issuer (via electronic mail (at an electronic mail address provided to the Calculation Agent
by the Issuer in Section 18.1 herein), followed by a telephonic confirmation), the Paying Agent (if the Calculation Agent
is not the Paying Agent) and the Trustee of the interest rate for the new interest period.

 

    6

     

    

 

		(b)	The Calculation Agent will, upon the written request of any holder of the Floating Rate Notes,
provide the interest rate then in effect with respect to the Floating Rate Notes and, if determined, the interest rate that will
become effective in the next interest period. The rights of holders to receive the payments of interest on the Notes are subject
to applicable procedures of Euroclear Bank SA/NV and Clearstream Banking, S.A. The Trustee, Paying Agent, Transfer Agent and Registrar
shall not be responsible for nor incur any liability in relation to any computation of interest made by the Calculation Agent.

 

		(c)	The Calculation Agent shall not have any (i) liability for the selection, adoption or determination
of an alternative or replacement reference rate as a successor or replacement for EURIBOR (as defined in the Indenture), or (ii) liability
for any failure or delay by the Issuer in performing its respective duties under the Indenture or other transaction documents as
a result of the unavailability of EURIBOR or the Alternate Rate (as defined in the Indenture).

 

		9.	Repayment

 

Any sums paid by, or by arrangement
with the Issuer to the Paying Agent pursuant to the terms of this Agreement shall not be required to be repaid to the Issuer unless
and until the Notes in respect of which such sums were paid shall have been purchased by the Issuer or any other subsidiary of
the Issuer and cancelled, but in any of these events the Paying Agent shall (provided that all other amounts due under this Agreement
shall have been duly paid) upon written request by the Issuer forthwith repay to the Issuer sums equivalent to the amounts which
would otherwise have been payable on the relevant Notes together with any fees previously paid to the Paying Agent in respect of
such Notes. Notwithstanding the foregoing, the Paying Agent shall not be obliged to make any repayment to the Issuer so long as
any amounts which under this Agreement should have been paid to or to the order of the Paying Agent by the Issuer shall remain
unpaid. The Paying Agent shall not, however, be otherwise required or entitled to repay any sums properly received by it under
this Agreement.

 

		10.	Prepayment; Notice of Withholding or Deduction

 

		10.1	The Issuer shall provide to the Paying Agent a copy of all notices of redemption delivered under
the Indenture in respect of the Notes that it serves on the holders of the Notes including, without limitation, details of the
date(s) on which such redemptions in respect of the Notes are to be made, all amounts required to be paid by the Issuer in
respect thereof in accordance with this Agreement and the Indenture and the manner in which such redemption will be effected.

 

    7

     

    

 

		10.2	If:

 

		(a)	the Issuer, in respect of any payment; or

 

		(b)	the Paying Agent, in respect of any payment of principal of or any premium or interest on the Notes,
is required to withhold or deduct any amount for or on account of Tax,

 

		(c)	the Issuer shall give notice thereof to the Paying Agent and the Trustee as soon as it becomes
aware of such requirement and shall give to the Paying Agent such information as the Paying Agent requires to enable it to make
such deduction or withholding; and

 

		(d)	except where such requirement arises as a result of prepayment of the Notes in accordance with
the Indenture or by virtue of the relevant holder failing to satisfy any certification or other requirement in respect of its Notes,
the Paying Agent shall give notice thereof to the Issuer and the Trustee as soon as it becomes aware of the requirement to withhold
or deduct.

 

In the event that the Issuer determines
in its sole discretion that withholding will be required by applicable law in connection with any payment due to the Paying Agent
on any Notes, then the Issuer will be entitled to redirect or reorganise any such payment in any way that it sees fit in order
that the payment may be made without such withholding provided that, any such redirected or reorganised payment is made through
a recognised institution of international standing and otherwise made in accordance with this Agreement and the Indenture. The
Issuer will promptly notify the Paying Agent and the Trustee of any such redirection or reorganisation.

 

		11.	Issue of Replacement Notes

 

		11.1	The Trustee shall, on issuing any replacement definitive note, forthwith inform the Issuer and
the Transfer Agent of the serial number of the replacement definitive note issued and (if known) of the serial number of the definitive
note in place of which the replacement definitive note has been issued.

 

		11.2	Whenever a definitive note for which a replacement definitive note has been issued is presented
to the Paying Agent for payment of principal or a Transfer Agent for transfer, the relevant agent shall immediately send notice
to the Issuer and (if it is not itself the Paying Agent) the Paying Agent.

 

		12.	Records

 

The Paying Agent shall:

 

		(a)	keep a full and complete record of all payments made by it in respect of the Notes; and

 

		(b)	make such records available at all reasonable times to the Issuer and any persons authorised by
it, and the Trustee for inspection and for the taking of copies thereof.

 

		13.	Fees And Expenses

 

		13.1	The Issuer will pay to each Agent such fees and expenses in respect of such Agent’s services
under this Agreement as agreed to in the fee letter dated March 13, 2020 from the Agents to, and countersigned by, the Issuer.

 

    8

     

    

 

		13.2	The Issuer will also pay on demand, against presentation of such invoices and receipts as it may
reasonably require, all out-of-pocket expenses (including necessary advertising, facsimile and telex transmission, postage and
insurance expenses and, subject to prior approval by the Issuer as set forth below, the fees and expenses of legal advisers) properly
incurred by each Agent in connection with the services under this Agreement, together with any applicable value added tax or similar
tax properly chargeable thereon. Payment by the Issuer to each Agent of such out-of-pocket expenses shall be a good discharge of
the obligations of the Issuer in respect thereof. Where the advice of legal counsel is sought by the Paying Agent, Calculation
Agent, Transfer Agent or Registrar, the fees of any such counsel shall be agreed to by the Issuer (acting reasonably) in advance.

 

		14.	Indemnity

 

		14.1	The Issuer undertakes to indemnify and hold harmless, each Agent and each of its respective directors,
officers, employees or agents (each an “Indemnified Party”) on demand by such Indemnified Party against any
losses, liabilities, costs, fees, expenses, claims, actions, damages or demands (including, but not limited to, all reasonable
costs, charges and expenses paid or incurred in disputing or defending the foregoing or enforcing the terms of this Agreement (including
the indemnification provided herein) and the properly incurred fees and expenses of legal advisers) which such Indemnified Party
may incur or which may be made against it (whether asserted by the Issuer, any Holder or any third party), as a result of or in
connection with the appointment or the exercise of or performance of its powers and duties under this Agreement, except such as
may result from such Agent’s own gross negligence, wilful misconduct or fraud or that of its directors, officers, employees
or agents as determined in a final non-appealable judgment by a court of competent jurisdiction.

 

		14.2	The indemnity contained in clause 14.1 above shall survive the termination and expiry of this Agreement
or the resignation or removal of any Agent.

 

		15.	Conditions of Appointment

 

		15.1	The Paying Agent shall (a) hold all sums receives from Issuer in accordance with this Agreement
and the Indenture for payment of principal of or any premium or interest on the Notes in trust for the benefit of the Trustee until
such sums shall be paid to such persons or otherwise disposed of as provided in this Agreement and the Indenture; (b) give
the Trustee notice of any default by the Issuer (or any other obligor upon the Notes) in the making of any payment of principal
of or premium or interest on the Notes; and (c) at any time during the continuance of any such default, upon the written request
of the Trustee, forthwith pay to the Trustee all sums held by it in trust for payment in respect of the Notes.

 

		15.2	No monies held by the Paying Agent need be segregated except as required by law.

 

		15.3	In acting under this Agreement and in connection with the Notes, each Agent shall act solely as
an agent of the Issuer and, save solely in respect of its obligations under clause 15.1 hereof, shall not have any obligations
towards or relationship of agency or trust with any of the holders of the Notes or the Trustee.

 

		15.4	Each Agent shall be obliged to perform such duties and only such duties as are specifically set
out in this Agreement, in the Indenture and in the Notes. No implied duties or obligations shall be read into such document. No
Agent shall be obliged to perform any duties additional to or different from such duties resulting from any modification or supplement
after the date hereof to any relevant documents (including, without limitation, the Indenture), unless it shall have previously
agreed to perform such duties. No Agent shall be under any obligation to take any action hereunder which either party expects,
and has thus notified the Issuer in writing, will result in any expense or liability of such Agent, the payment of which within
a reasonable time is not, in its opinion, assured to it.

 

    9

     

    

 

		15.5	Except as ordered by a court of competent jurisdiction or as required by law, the Paying Agent
shall be entitled to treat the holder of any Note (as evidenced by the register of Notes maintained by the Registrar) as the absolute
owner thereof for all purposes (whether or not it is overdue and notwithstanding any notice to the contrary or any notice of ownership,
trust or any interest in it, any writing on it, or its theft or loss) and shall not be required to obtain any proof thereof or
as to the identity of the bearer or holder.

 

		15.6	Each Agent may consult with any legal or other professional advisers (who may be an employee of
or legal adviser to the Issuer) selected by it, at the cost of the Issuer, provided that the fees of any such counsel shall be
agreed to by the Issuer (acting reasonably) in advance, and the opinion of such advisers shall be full and complete protection
in respect of any action taken, omitted or suffered hereunder in accordance with the written opinion of such advisers.

 

		15.7	Each Agent shall be protected and shall incur no liability for or in respect of any action taken,
suffered or omitted by it in reliance upon any instruction, request or order from the Issuer or upon any Note, notice, resolution,
direction, consent, certificate, affidavit, statement, telex, facsimile transmission or other document or information from any
electronic or other source reasonably believed by it to be genuine and to have been signed or otherwise given or disseminated by
the proper party or parties, even if it is subsequently found not to be genuine or to be incorrect.

 

		15.8	Each Agent, whether acting for itself or in any other capacity, will not be precluded from becoming
the owner of, or acquiring any interest in, holding or disposing of any Note or any shares or other securities of the Issuer or
any of its subsidiaries, holding or associated companies (each a “Connected Company”), with the same rights
as it would have had if it were not acting as Paying Agent or from entering into or being interested in any contracts or transactions
with any Connected Company or from acting on, or as depositary, trustee or agent for, any committee or body of holders of any securities
of any Connected Company and will not be liable to account for any profit.

 

		15.9	The Paying Agent shall not be required to make any payments to any holder of a Note if under any
laws or regulations affecting the Paying Agent, such payment is not permitted. In the event of any such laws or regulations affecting
the Paying Agent coming to the attention of the Paying Agent it shall forthwith notify the Issuer and the Trustee.

 

		15.10	The Issuer shall do or cause to be done all such acts, matters and things and shall make available
all such documents as shall be necessary or desirable to enable each Agent to fully comply with and carry out its respective duties
and obligations hereunder.

 

		15.11	In no event shall any Agent or any of its affiliates or any of their respective officers, directors,
employees, agents, advisors or representatives (collectively, “Agent Parties”) have any liability for damages
of any kind, including, without limitation, direct or indirect, special, incidental or consequential damages, losses or expenses
(whether in tort, contract or otherwise).

 

    10

     

    

 

		15.12	Notwithstanding anything contained in this Agreement to the contrary, no Agent shall incur any
liability for not performing any act or fulfilling any obligation hereunder by reason of any occurrence beyond its control including,
without limitation, (i) any governmental activity (whether de jure or de facto), act of authority (whether lawful or unlawful),
compliance with any governmental or regulatory order, rule, regulation or direction, curfew restriction, expropriation, compulsory
acquisition, seizure, requisition, nationalisation or the imposition of currency or currency control restrictions; (ii) any
failure of or the effect of rules or operations of any funds transfer, settlement or clearing system, interruption, loss or
malfunction of utilities, communications or computer services or the payment or repayment of any cash or sums arising from the
application of any law or regulation in effect now or in the future, or from the occurrence of any event in the country in which
such cash is held which may affect, limit, prohibit or prevent the transferability, convertibility, availability, payment or repayment
of any cash or sums until such time as such law, regulation or event shall no longer affect, limit, prohibit or prevent such transferability,
convertibility, availability, payment or repayment (and in no event, other than as provided in the Notes, shall any Agent be obliged
to substitute another currency for a currency whose transferability, convertibility or availability has been affected, limited,
prohibited or prevented by such law, regulation or event or be obliged to pay any penalty interest); (iii) any strike or work
stoppage, go slow, occupation of premises, other industrial action or dispute or any breach of contract by any essential personnel;
(iv) any equipment or transmission failure or failure of applicable banking or financial systems; (v) any war, armed
conflict including but not limited to hostile attack, hostilities, or acts of a foreign enemy; (vi) any riot, insurrection,
civil commotion or disorder, mob violence or act of civil disobedience; (vii) any act of terrorism or sabotage; (viii) any
explosion, fire, destruction of machines, equipment or any kind of installation, prolonged breakdown of transport, radioactive
contamination, nuclear fusion or fission or electric current; (ix) any epidemic, natural disaster (such as but not limited
to violent storm, hurricane, blizzard, earthquake, landslide, tidal wave, flood, damage or destruction by lightning, or drought);
or (x) any other act of God.

 

		15.13	Pursuant to and in accordance with the procedures set forth in Section 10.3 of the Indenture
(i) the Issuer may at any time, for the purpose of obtaining the satisfaction and discharge of the Indenture or for any other
purpose, direct the Paying Agent to pay to the Trustee all sums held in trust by the Paying Agent, such sums to be held by the
Trustee upon the same trusts as those upon which such sums were held by the Paying Agent; and, upon such payment by the Paying
Agent to the Trustee, the Paying Agent shall be released from all further liability with respect to such money and (ii) any
money deposited with the Paying Agent in trust for the payment of the principal of or any premium or interest on the Notes remaining
unclaimed for two years after such principal, premium or interest has become due and payable shall be paid to the Issuer on the
Issuer’s request and all liability of the Paying Agent with respect to such trust money shall thereupon cease.

 

		15.14	The rights, protections, immunities and indemnities afforded to the Trustee under the Indenture
shall also be afforded to each Agent mutatis mutandis; provided (i) an Agent shall only be liable to the extent
of its gross negligence, wilful misconduct or fraud; and (ii) in and during an Event of Default (as defined in the Indenture),
only the Trustee, and not any Agent, shall be subject to the prudent person standard.

 

		16.	Changes in Paying Agent Calculation Agent, Transfer Agent
or Registrar and Specified Offices

 

		16.1	The Issuer may at any time vary or terminate the appointment of the Paying Agent, Calculation Agent,
Transfer Agent or the Registrar and appoint additional or other paying agents or registrars.

 

Any variation or termination
shall be made by giving to the Paying Agent, Calculation Agent, Transfer Agent or Registrar and (if different) to the paying agent,
transfer agent or registrar whose appointment is to be varied or terminated not less than 30 days’ written notice to that
effect, which notice shall expire not less than 30 days before or after any due date for any payment in respect of Notes.

 

		16.2	Subject to clause 16.1, no Agent may resign its appointment hereunder at any time by giving to
the Issuer not less than 60 days’ written notice to that effect, which notice shall expire not less than 30 days before or
after any due date for any payments in respect of any Notes.

 

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		16.3	Notwithstanding clauses 16.1 and 16.2 no such termination of the appointment of, or resignation
by, any Agent shall take effect until a successor has been appointed on terms approved by the Issuer or the Issuer has otherwise
approved such resignation without a successor being appointed.

 

		16.4	Notwithstanding any other provisions of clause 16.1, the appointment of any Agent shall forthwith
terminate if at any time such Agent becomes incapable of acting, or is adjudged bankrupt or insolvent, or files a voluntary petition
in bankruptcy or makes an assignment for the benefit of its creditors or consents to the appointment of a receiver, administrator
or other similar official of it or of all or any substantial part of its property or admits in writing its inability to pay or
meet its debts as they mature or suspends payment thereof, or if a resolution is passed or an order made for its winding up or
dissolution, or if a receiver, administrator or other similar official of it or of all or any substantial part of its property
is appointed, or if any order of any court is entered approving any petition filed by or against it under the provisions of any
applicable bankruptcy or insolvency law, or if any public officer takes charge or control of such Agent or its property or affairs
for the purpose of rehabilitation, conservation, administration or liquidation or there occurs any analogous event under any applicable
law.

 

		16.5	On the date on which any such termination or resignation takes effect, such Agent shall (upon written
direction of the Issuer) (i) deliver to its successor (or, if none, the Issuer) any amounts held by it in respect of the Notes
which have become due and payable but which have not been presented for payment; and (ii) deliver to its successor (or, if
none, the Issuer), or as it may direct, all records maintained by it, pursuant hereto. Following such termination or resignation
and pending such payment and delivery, such Agent shall hold such amounts, records and documents in trust for and subject to the
order of its successor or, as the case may be, the Issuer.

 

		16.6	Any corporation into which any Agent may be merged or converted or any corporation with which such
Agent may be consolidated or any corporation resulting from any merger, conversion or consolidation to which such Agent shall be
a party, or any corporation, including affiliated corporations, to which the Agent shall sell or otherwise transfer: (a) all
or substantially all of its assets or (b) all or substantially all of its corporate trust business shall, on the date when
the merger, conversion, consolidation or transfer becomes effective and to the extent permitted by any applicable laws, be the
successor paying agent, calculation agent, transfer agent or registrar under this Agreement without any further formality, and
after such effective date all references in this Agreement to such Paying Agent, Calculation Agent, Transfer Agent or Registrar
shall be deemed to be references to such corporation. Notice of any such merger, conversion, consolidation or transfer shall forthwith
be given by the Paying Agent, Calculation Agent, Transfer Agent or Registrar to the Issuer and the Trustee.

 

		16.7	Any Agent may change its specified office to another office in London at any time by giving to
the Issuer and the Trustee not less than 60 days’ prior written notice to that effect, which notice shall expire not less
than 30 days before or after any due date for any payments in respect of any Notes, and which notice shall specify the address
of the new specified office and the date upon which such change is to take effect.

 

		17.	Notices

 

		17.1	If the Issuer arranges publication of any notice to the holders of the Notes, it shall at or before
the time of such publication, send copies of each notice so published to the Paying Agent.

 

		17.2	Notwithstanding the above and on behalf of and at the request and expense of the Issuer, the Paying
Agent shall cause to be published all notices required to be given by the Issuer under the Indenture.

 

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		17.3	Any Agent shall promptly forward any written notice received by it from any holders of the Notes
to the Issuer and the Trustee.

 

		18.	Communications

 

		18.1	For the purposes of this clause, the address of each party at the date of this Agreement shall
be the address set out below (including, where applicable, the details of the facsimile number, the person for whose attention
the notice or communication is to be addressed and the email address):

 

the Issuer:

 

	AbbVie Inc.	 
	
        1 North Waukegan Road

        North Chicago, Illinois 60064

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: +1 847-938-8779

        Attention: Vice President, Tax and Treasury

        Email: scott.reents@abbvie.com

 

the Paying Agent:

 

	Elavon Financial Services DAC, UK Branch	 
	
        125 Old Broad Street

        London

        EC2N 1AR

        United Kingdom

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: +44 (0)207 365 2577

        Attention: MBS Relationship Management

        Email: mbs.relationship.management@usbank.com

 

the Calculation Agent:

 

	Elavon Financial Services DAC, UK Branch	 
	
        125 Old Broad Street

        London

        EC2N 1AR

        United Kingdom

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: +44 (0)207 365 2577

        Attention: MBS Relationship Management

        Email: mbs.relationship.management@usbank.com

 

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the Transfer Agent:

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email: linda.garcia@usbank.com

 

the Registrar:

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email: linda.garcia@usbank.com

 

the Trustee:

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with the Indenture
        and notified by the Issuer to the Paying Agent.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email:linda.garcia@usbank.com

 

		19.	Amendments

 

		19.1	For the avoidance of doubt, this Agreement may be amended in writing by the parties hereto. No
Agent shall be obligated to enter into any amendment or supplement to this Agreement, or to perform duties pursuant to an amendment
to the Indenture or the Notes that adversely affects its duties or protections without, its consent.

 

		19.2	The Issuer shall provide to each Agent a copy of any amendment to the Indenture as soon as reasonably
practicable following such amendment taking effect. Where reference is made in this Agreement to the Indenture, such reference
shall, for the purposes of such Agent’s rights and obligations under this Agreement only, be deemed to refer to the most
recent version of such document provided to such Agent by the Issuer.

 

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		20.	Taxes

 

		20.1	The Issuer agrees to pay any and all stamp and other documentary taxes or duties which may be payable
in connection with the execution, delivery, performance and enforcement of this Agreement.

 

		21.	Regulatory Matters

 

		21.1	The Paying Agent and the Calculation Agent are authorised and regulated by the Central Bank of
Ireland (“CBOI”) and its activities in the UK are subject to limited regulation by the UK Prudential Regulation
Authority (“PRA”) and the UK Financial Conduct Authority (“FCA”).

 

		21.2	In connection with the worldwide effort against the funding of terrorism and money laundering activities,
an Agent may be required under various national laws and regulations to which they are subject to obtain, verify and record information
that identifies each person who opens an account with it. For a non-individual person such as a business entity, a charity, a Trust
or other legal entity, such Agent shall be entitled to ask for documentation to verify such entity’s formation and legal
existence as well as financial statements, licenses, identification and authorisation documents from individuals claiming authority
to represent the entity or other relevant documentation.

 

		21.3	The parties to this Agreement acknowledge and agree that the obligations of any Agent under this
Agreement are limited by and subject to compliance by them with EU and US Federal anti-money laundering statutes and regulations,
as applicable. If such Agent or any of their directors know or suspect that a payment is the proceeds of criminal conduct, such
person is required to report such information pursuant to the applicable authorities and such report shall not be treated as a
breach by such person of any confidentiality covenant or other restriction imposed on such person under this Agreement, by law
or otherwise on the disclosure of information. The Agents shall be indemnified and held harmless by the Issuer from and against
all losses suffered by them that may arise as a result of the agents being prevented from fulfilling their obligations hereunder
due to the extent doing so would not be consistent with applicable statutory anti-money laundering requirements.

 

		21.4	Notwithstanding anything to the contrary in this Agreement or in any other agreement, arrangement
or understanding among any such parties, each party hereto acknowledges that any liability of any party arising under this Agreement
or any such other document, to the extent such liability is unsecured or not otherwise exempted, may be subject to the write-down
and conversion powers of a Resolution Authority and agrees and consents to, and acknowledges and agrees to be bound by:

 

		(a)	the application of any Write-Down and Conversion Powers by a Resolution Authority to any such liabilities
arising hereunder which may be payable to it by any party hereto; and

 

		(b)	the effects of any Bail-in Action on any such liability, including, if applicable:

 

		1.	a reduction in full or in part or cancellation of any such liability;

 

		2.	a conversion of all, or a portion of, such liability into shares or other instruments of ownership
in such party, its parent undertaking, or a bridge institution that may be issued to it or otherwise conferred on it, and that
such shares or other instruments of ownership will be accepted by it in lieu of any rights with respect to any such liability under
this Agreement or any other agreement; or

 

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		3.	the variation of the terms of such liability in connection with the exercise of the Write-Down
and Conversion Powers of any Resolution Authority.

 

For the purpose of this sub-clause 21.4
the following terms shall have the following meanings:

 

“Bail-In Action” means
the exercise of any Write-Down and Conversion Powers by the applicable Resolution Authority.

 

“Bail-In Legislation”
means, with respect to any EEA Member Country implementing Article 55 of Directive 2014/59/EU of the European Parliament and
of the Council of the European Union, the implementing law for such EEA Member Country from time to time which is described in
the EU Bail-In Legislation Schedule and in relation to any other state, any analogous law or regulation from time to time which
requires contractual recognition of any Write-down and Conversion Powers contained in that law or regulation.

 

“EEA Member Country”
means any of the member states of the European Union, Iceland, Liechtenstein, and Norway.

 

“EU Bail-In Legislation Schedule”
means the EU Bail-In Legislation Schedule published by the Loan Market Association (or any successor person), as in effect from
time to time.

 

“Resolution Authority”
means any public administrative authority or any person entrusted with public administrative authority to exercise any Write-down
and Conversion Powers.

 

“Write-Down and Conversion Powers”
means,

 

		(a)	in relation to any Bail-In Legislation described in the EU Bail-In Legislation Schedule from time
to time, the powers described as such in relation to that Bail-In Legislation in the EU Bail-In Legislation Schedule; and

 

		(b)	any powers under the Bail-In Legislation to cancel, transfer or dilute shares issued by a person
that is a bank or investment firm or other financial institution or affiliate of a bank, investment firm or other financial institution,
to cancel, reduce, modify or change the form of a liability of such a person or any contract or instrument under which that liability
arises, to convert all or part of that liability into shares, securities or obligations of that person or any other person, to
provide that any such contract or instrument is to have effect as if a right had been exercised under it or to suspend any obligation
in respect of that liability or any of the powers under that Bail-In Legislation that are related to or ancillary to any of those
powers; and any similar or analogous powers under that Bail-In Legislation.

 

		22.	Governing Law and Jurisdiction; Waiver of Jury Trial;
Service of Process

 

		22.1	This Agreement shall be construed and enforced in accordance with, and the rights of the parties
shall be governed by, the law of the State of New York.

 

		22.2	Each of the Agents and the Issuer irrevocably submits to the non-exclusive jurisdiction of any
New York State or federal court sitting in the Borough of Manhattan, The City of New York, over any suit, action or proceeding
arising out of or relating to this Agreement. To the fullest extent permitted by applicable law, each of the Agents and the Issuer
irrevocably waives and agrees not to assert, by way of motion, as a defense or otherwise, any claim that it is not subject to the
jurisdiction of any such court, any objection that it may now or hereafter have to the laying of the venue of any such suit, action
or proceeding brought in any such court and any claim that any such suit, action or proceeding brought in any such court has been
brought in an inconvenient forum.

 

    16

     

    

 

		22.3	Each of the Agents and the Issuer agrees, to the fullest extent permitted by applicable law, that
a final judgment in any suit, action or proceeding of the nature referred to in clause 22.2 brought in any such court shall be
conclusive and binding upon it subject to rights of appeal, as the case may be, and may be enforced in the courts of the United
States of America or the State of New York (or any other courts to the jurisdiction of which it or any of its assets is or may
be subject) by a suit upon such judgment.

 

		22.4	THE PARTIES HERETO HEREBY WAIVE TRIAL BY JURY IN ANY ACTION BROUGHT ON OR WITH RESPECT TO THIS
AGREEMENT.

 

		22.5	The Issuer waives personal service of process and consents to service of process by certified or
registered mail, return receipt requested, directed to it at the address last specified for notices hereunder, and such service
shall be deemed completed ten (10) calendar days after the same is so mailed.

 

		23.	Counterparts

 

This Agreement may be executed
in any number of counterparts and the signatories of all parties need not appear on the same counterpart. Each counterpart, when
executed and delivered, shall be an original, but all of which when taken together shall constitute a single instrument. The delivery
of signed counterparts by facsimile or electronic transmission that includes a copy of the sending party’s signature is as
effective as signing and delivering the counterpart in person.

 

		24.	Severability

 

In case any one or more of the
provisions contained in this Agreement should be or become invalid, illegal or unenforceable in any respect, the validity, legality
and enforceability of the remaining provisions contained herein or therein shall in no way be affected, prejudiced or disturbed
thereby.

 

		25.	Benefit of Agreement

 

This Agreement is for the exclusive
benefit of the parties hereto, and their respective successors hereunder, and shall not be deemed to give any legal or equitable
right, remedy or claim to any other person whatsoever.

 

    17

     

    

 

AS WITNESS the hands of the parties
or their duly authorised agents the day and year first above written.

 

ABBVIE INC., AS ISSUER

 

	By:	/s/ Scott T. Reents	 
	Name:	Scott T. Reents	 
	Title:	Vice President, Tax and Treasury	 

 

ELAVON FINANCIAL SERVICES DAC, U.K. BRANCH, AS PAYING AGENT
AND CALCULATION AGENT

  

	By:	/s/ David Harnett

	 
	Name:	David Harnett 

	 
	Title:	Authorised Signatory

	 

 

U.S. BANK NATIONAL ASSOCIATION, AS TRANSFER AGENT AND REGISTRAR

 

	By:	/s/ Linda Garcia

	 
	Name:	Linda Garcia

	 
	Title:	Vice President

	 

 

U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE

 

	By:	/s/ Linda Garcia

	 
	Name:	Linda Garcia

	 
	Title:	Vice President

	 

 

     

     

    

 

APPENDIX 1

 

Indenture

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