Document:

EX-10.1

 Exhibit 10.1 

VOTING AGREEMENT 
 THIS
VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Zalicus”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the
“Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of Zalicus. 

WHEREAS, Zalicus, BRunning, Inc., a Delaware corporation and a wholly owned subsidiary of Zalicus (“Merger Sub”), and
the Company, have entered into an Agreement and Plan of Merger and Reorganization, dated of even date herewith (the “Merger Agreement”), providing for the merger of Merger Sub with and into the Company (the
“Merger”); 
 WHEREAS, Stockholder beneficially owns and has sole or shared voting power with respect to the number
of Shares, and holds stock options or other rights to acquire the number of Shares indicated opposite Stockholder’s name on Schedule 1 attached hereto; 

WHEREAS, as an inducement and a condition to the willingness of Zalicus, Merger Sub and the Company to enter into the Merger Agreement,
and in consideration of the substantial expenses incurred and to be incurred by them in connection therewith, Stockholder has agreed to enter into and perform this Agreement; and 

WHEREAS, all capitalized terms used in this Agreement without definition herein shall have the meanings ascribed to them in the Merger
Agreement. 
 NOW, THEREFORE, in consideration of, and as a condition to, Zalicus’s, Merger Sub’s and the Company’s
entering into the Merger Agreement and proceeding with the transactions contemplated thereby, and in consideration of the expenses incurred and to be incurred by them in connection therewith, Stockholder, Zalicus and the Company agree as follows:

 1. Agreement to Vote Shares. Stockholder agrees that, prior to the Expiration Date (as defined in Section 2 below), at
any meeting of the stockholders of Zalicus or any adjournment or postponement thereof, or in connection with any written consent of the stockholders of Zalicus, with respect to the Merger, the Merger Agreement or any Zalicus Acquisition Proposal,
Stockholder shall: 
 (a) appear at such meeting or otherwise cause the Shares and any New Shares (as defined in
Section 3 below) to be counted as present thereat for purposes of calculating a quorum; 
 (b) from and after the
date hereof until the Expiration Date, vote (or cause to be voted), or deliver a written consent (or cause a written consent to be delivered) covering all of the Shares and any New Shares that such Stockholder shall be entitled to so vote:
(i) in favor of adoption and approval of (A) the issuance of the shares of Zalicus Common Stock by virtue of the Merger, and (B) an amendment to the Zalicus Charter to effect the Reverse Stock Split; (ii) against any action or
agreement that, to the knowledge 

 
of Stockholder, would reasonably be expected to result in a breach in any material respect of any covenant, representation or warranty or any other obligation or agreement of Zalicus or any of
its Subsidiaries or Affiliates under the Merger Agreement or that would reasonably be expected to result in any of the conditions to Zalicus’s or any of its Subsidiaries’ or Affiliates’ obligations under the Merger Agreement not being
fulfilled; and (iii) against any Zalicus Acquisition Proposal, or any agreement, transaction or other matter that is intended to, or would reasonably be expected to, impede, interfere with, delay, postpone, discourage or materially and
adversely affect the consummation of the Merger and all other transactions contemplated by the Merger Agreement. The Stockholder shall not take or commit or agree to take any action inconsistent with the foregoing. 

2. Expiration Date. As used in this Agreement, the term “Expiration Date” shall mean the earlier to occur of
(a) the Effective Time, (b) such date and time as the Merger Agreement shall be terminated pursuant to Section 9 thereof or otherwise, or (c) upon mutual written agreement of the parties to terminate this Agreement. Upon
termination or expiration of this Agreement, no party shall have any further obligations or liabilities under this Agreement; provided, however, such termination or expiration shall not relieve any party from liability for any willful
breach of this Agreement or acts of bad faith prior to termination hereof. 
 3. Additional Purchases. Stockholder agrees that any
shares of capital stock or other equity securities of Zalicus that Stockholder purchases or with respect to which Stockholder otherwise acquires sole or shared voting power after the execution of this Agreement and prior to the Expiration Date,
whether by the exercise of any stock options or otherwise (“New Shares”), shall be subject to the terms and conditions of this Agreement to the same extent as if they constituted the Shares. 

4. Agreement to Retain Shares. From and after the date hereof until the Expiration Date, Stockholder shall not, directly or indirectly,
(a) sell, assign, transfer, tender, or otherwise dispose of (including, without limitation, by the creation of any Liens (as defined in Section 5(c) below)) any Shares, (b) deposit any Shares or New Shares into a voting trust
or enter into a voting agreement or similar arrangement with respect to such Shares or New Shares or grant any proxy or power of attorney with respect thereto (other than this Agreement), (c) enter into any contract, option, commitment or other
arrangement or understanding with respect to the direct or indirect sale, transfer, assignment or other disposition of (including, without limitation, by the creation of any Liens) any Shares or New Shares, or (d) take any action that would
make any representation or warranty of Stockholder contained herein untrue or incorrect or have the effect of preventing or disabling Stockholder from performing Stockholder’s obligations under this Agreement. Notwithstanding the foregoing,
Stockholder may make (a) transfers by will or by operation of law or other transfers for estate-planning purposes, in which case this Agreement shall bind the transferee, (b) with respect to such Stockholder’s Company Options which
expire on or prior to the Expiration Date, transfers, sale, or other disposition of Shares to the Company as payment for the (i) exercise price of such Stockholder’s Company Options and (ii) taxes applicable to the exercise of such
Stockholder’s Company Options, (c) if Stockholder is a partnership or limited liability company, a transfer to one or more partners or members of Stockholder or to an affiliated corporation, trust or other business entity under common
control 

  
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with Stockholder, or if Stockholder is a trust, a transfer to a beneficiary, provided that in each such case the applicable transferee has signed a voting agreement in substantially the form
hereof, (d) to another holder of the capital stock of the Company that has signed a voting agreement in substantially the form hereof, and (e) as Phoenix may otherwise agree in writing in its sole discretion. 

5. Representations and Warranties of Stockholder. Stockholder hereby represents and warrants to Zalicus and the Company as follows:

 (a) Stockholder has the full power and authority to execute and deliver this Agreement and to perform Stockholder’s
obligations hereunder; 
 (b) this Agreement has been duly executed and delivered by or on behalf of Stockholder and, to the
Stockholder’s knowledge and assuming this Agreement constitutes a valid and binding agreement of the Company and Zalicus, constitutes a valid and binding agreement with respect to Stockholder, enforceable against Stockholder in accordance with
its terms, except as enforcement may be limited by general principles of equity whether applied in a court of law or a court of equity and by bankruptcy, insolvency and similar laws affecting creditors’ rights and remedies generally; 

(c) except as set forth on Schedule 1, Stockholder beneficially owns the number of Shares indicated opposite such
Stockholder’s name on Schedule 1, and will own any New Shares, free and clear of any liens, claims, charges or other encumbrances or restrictions of any kind whatsoever (“Liens”), and has sole or shared, and
otherwise unrestricted, voting power with respect to such Shares or New Shares and none of the Shares or New Shares is subject to any voting trust or other agreement, arrangement or restriction with respect to the voting of the Shares or the New
Shares, except as contemplated by this Agreement; 
 (d) to the knowledge of Stockholder, the execution and delivery of this
Agreement by Stockholder does not, and the performance by Stockholder of his or her obligations hereunder and the compliance by Stockholder with any provisions hereof will not, violate or conflict with, result in a material breach of or constitute a
default (or an event that with notice or lapse of time or both would become a material default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, or result in the creation of any Liens on any Shares or
New Shares pursuant to, any agreement, instrument, note, bond, mortgage, contract, lease, license, permit or other obligation or any order, arbitration award, judgment or decree to which Stockholder is a party or by which Stockholder is bound, or
any law, statute, rule or regulation to which Stockholder is subject or, in the event that Stockholder is a corporation, partnership, trust or other entity, any bylaw or other organizational document of Stockholder; and 

(e) to the knowledge of Stockholder, the execution and delivery of this Agreement by Stockholder does not, and the performance
of this Agreement by Stockholder does not and will not, require any consent, approval, authorization or permit of, or filing with or notification to, any governmental or regulatory authority by 

  
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Stockholder except for applicable requirements, if any, of the Exchange Act, and except where the failure to obtain such consents, approvals, authorizations or permits, or to make such filings or
notifications, would not prevent or delay the performance by Stockholder of his or her obligations under this Agreement in any material respect. 

6. Irrevocable Proxy. Subject to the penultimate sentence of this Section 6, by execution of this Agreement, Stockholder
does hereby appoint the Company with full power of substitution and resubstitution, as Stockholder’s true and lawful attorney and irrevocable proxy, to the fullest extent of the undersigned’s rights with respect to the Shares, to vote, if
the Stockholder is unable to perform his or her obligations under this Agreement, each of such Shares solely with respect to the matters set forth in Section 1 hereof. Stockholder intends this proxy to be irrevocable and coupled with an
interest hereunder until the Expiration Date and hereby revokes any proxy previously granted by Stockholder with respect to the Shares. Notwithstanding anything contained herein to the contrary, this irrevocable proxy shall automatically terminate
upon the Expiration Date of this Agreement. The Stockholder hereby revokes any proxies previously granted and represents that none of such previously-granted proxies are irrevocable. 

7. No Solicitation. From and after the date hereof until the Expiration Date, Stockholder shall not (a) initiate, solicit, seek or
knowingly encourage or support any inquiries, proposals or offers that constitute or may reasonably be expected to lead to, a Zalicus Acquisition Proposal, (b) engage or participate in, or knowingly facilitate, any discussions or negotiations
regarding any inquiries, proposals or offers that constitute, or may reasonably be expected to lead to, a Zalicus Acquisition Proposal, (c) furnish to any Person other than the Company any non-public information that could reasonably be
expected to be used for the purposes of formulating any Zalicus Acquisition Proposal, (d) enter into any letter of intent, agreement in principle or other similar type of agreement relating to a Zalicus Acquisition Proposal, or enter into any
agreement or agreement in principle requiring Zalicus to abandon, terminate or fail to consummate the transactions contemplated hereby, (e) initiate a stockholders’ vote or action by consent of the Zalicus’s stockholders with respect
to a Zalicus Acquisition Proposal, (f) except by reason of this Agreement, become a member of a “group” (as such term is defined in Section 13(d) of the Exchange Act) with respect to any voting securities of Zalicus that takes
any action in support of a Zalicus Acquisition Proposal or (g) propose or agree to do any of the foregoing. In the event that Stockholder is a corporation, partnership, trust or other entity, it shall not permit any of its Subsidiaries or
Affiliates to, nor shall it authorize any officer, director or representative of Stockholder, or any of its Subsidiaries or Affiliates to, undertake any of the actions contemplated by this Section 7. 

8. Waiver of Appraisal Rights; No Legal Actions. 

(a) The Stockholder hereby waives, and agrees not to exercise or assert, any appraisal rights under applicable law, including
Section 262 of the DGCL in connection with the Merger. 

  
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 (b) The Stockholder will not in its capacity as a stockholder of Zalicus bring,
commence, institute, maintain, prosecute or voluntarily aid any Legal Proceeding which (i) challenges the validity or seeks to enjoin the operation of any provision of this Agreement or (ii) alleges that the execution and delivery of this
agreement by the Stockholder, either alone or together with the other voting agreements and proxies to be delivered in connection with the execution of the Merger Agreement, or the approval of the Merger Agreement by the Board of Directors of
Zalicus, constitutes a breach of any fiduciary duty of the Board of Directors of Zalicus or any member thereof. 
 9. Other Remedies;
Specific Performance. Except as otherwise provided herein, any and all remedies herein expressly conferred upon a party will be deemed cumulative with, and not exclusive of, any other remedy conferred hereby, or by Law or equity upon such party,
and the exercise by a party of any one remedy will not preclude the exercise of any other remedy. The parties hereto agree that irreparable damage would occur in the event that any of the provisions of this Agreement were not performed in accordance
with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to seek an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions hereof
in any court of the United States or any state having jurisdiction, this being the addition to any other remedy to which they are entitled at Law or in equity. 

10. Directors and Officers. This Agreement shall apply to Stockholder solely in Stockholder’s capacity as a stockholder of
Zalicus and/or holder of options to purchase shares of Zalicus Common Stock and/or holder of warrants to purchase shares of Zalicus Common Stock and not in such Stockholder’s capacity as a director, officer or employee of Zalicus or any of its
Subsidiaries or in such Stockholder’s capacity as a trustee or fiduciary of any employee benefit plan or trust. Notwithstanding any provision of this Agreement to the contrary, nothing in this Agreement shall (or require Stockholder to
attempt to) limit or restrict a director and/or officer of Zalicus in the exercise of his or her fiduciary duties consistent with the terms of the Merger Agreement as a director and/or officer of Zalicus or in his or her capacity as a trustee or
fiduciary of any employee benefit plan or trust or prevent or be construed to create any obligation on the part of any director and/or officer of Zalicus or any trustee or fiduciary of any employee benefit plan or trust from taking any action in his
or her capacity as such director, officer, trustee and/or fiduciary. 
 11. No Ownership Interest. Nothing contained in this
Agreement shall be deemed to vest in the Company any direct or indirect ownership or incidence of ownership of or with respect to any Shares. All rights, ownership and economic benefits of and relating to the Shares shall remain vested in and belong
to Stockholder, and the Company does not have authority to manage, direct, superintend, restrict, regulate, govern, or administer any of the policies or operations of Zalicus or exercise any power or authority to direct Stockholder in the voting of
any of the Shares, except as otherwise provided herein. 
 12. Termination. This Agreement shall terminate and shall have no
further force or effect as of the Expiration Date. Notwithstanding the foregoing, nothing set forth in this Section 12 or elsewhere in this Agreement shall relieve either party hereto from any liability, or otherwise limit the
liability of either party from any liability for any intentional breach of any obligation or other provision contained in this Agreement. 

  
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 13. Further Assurances. Stockholder shall, from time to time, execute and deliver, or
cause to be executed and delivered, such additional or further consents, documents and other instruments as the Company or Zalicus may reasonably request for the purpose of effectively carrying out the transactions contemplated by this Agreement and
the Merger Agreement. 
 14. Disclosure. Stockholder hereby agrees that Zalicus and the Company may publish and disclose in the
Registration Statement, any resale registration statement relating thereto (including all documents and schedules filed with the SEC), the Proxy Statement, any prospectus filed with any regulatory authority in connection with the Merger and any
related documents filed with such regulatory authority and as otherwise required by Law, such Stockholder’s identity and ownership of Shares and the nature of such Stockholder’s commitments, arrangements and understandings under this
Agreement and may further file this Agreement as an exhibit to the Registration Statement or prospectus or in any other filing made by Zalicus or the Company as required by Law or the terms of the Merger Agreement, including with the SEC or other
regulatory authority, relating to the Merger, all subject to prior review and an opportunity to comment by Stockholder’s counsel. 

15. Notice. All notices and other communications hereunder shall be in writing and shall be deemed given if delivered personally or
sent by overnight courier (providing proof of delivery) or by facsimile transmission (providing confirmation of transmission) to the Company or Zalicus, as the case may be, in accordance with Section 10.8 of the Merger Agreement and to each
Stockholder at its address set forth on Schedule 1 attached hereto (or at such other address for a party as shall be specified by like notice). 

16. Severability. Any term or provision of this Agreement that is invalid or unenforceable in any situation in any jurisdiction shall
not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or provision in any other situation or in any other jurisdiction. If a final judgment of a
court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the parties hereto agree that the court making such determination shall have the power to limit such term or provision, to delete
specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this Agreement shall be
valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the parties hereto agree to replace such invalid or unenforceable term or provision with a valid and enforceable term or
provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision. 

17. Assignability. This Agreement shall be binding upon, and shall be enforceable by and inure solely to the benefit of, the parties
hereto and their respective successors and assigns; provided, however, that neither this Agreement nor any of a party’s rights or obligations hereunder may be assigned or delegated by such party without the prior written consent of the
other parties hereto, and any attempted assignment or delegation of this Agreement or any of such rights or obligations by such party without the other party’s prior written consent shall be void and of no effect. Nothing in this Agreement,
express or implied, is intended to or shall confer upon any Person (other than the parties hereto) any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. 

  
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 18. No Waivers. No waivers of any breach of this Agreement extended by the Company or
Zalicus to Stockholder shall be construed as a waiver of any rights or remedies of the Company or Zalicus, as applicable, with respect to any other stockholder of Zalicus who has executed an agreement substantially in the form of this Agreement with
respect to Shares held or subsequently held by such stockholder or with respect to any subsequent breach of the Stockholder or any other such stockholder of Zalicus. No waiver of any provisions hereof by any party shall be deemed a waiver of any
other provisions hereof by any such party, nor shall any such waiver be deemed a continuing waiver of any provision hereof by such party. 

19. Applicable Law; Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the Laws of the State of
Delaware, regardless of the Laws that might otherwise govern under applicable principles of conflicts of Laws. In any action or proceeding between any of the parties arising out of or relating to this Agreement, each of the parties:
(i) irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Court of Chancery of the State of Delaware or to the extent such court does not have subject matter jurisdiction, the Superior Court of the
State of Delaware or the United States District Court for the District of Delaware, (ii) agrees that all claims in respect of such action or proceeding shall be heard and determined exclusively in accordance with clause (i) of this
Section 19, (iii) waives any objection to laying venue in any such action or proceeding in such courts, (iv) waives any objection that such courts are an inconvenient forum or do not have jurisdiction over any party, and
(v) agrees that service of process upon such party in any such action or proceeding shall be effective if notice is given in accordance with Section 15 of this Agreement. 

20. Waiver of Jury Trial. The parties hereto hereby waive any right to trial by jury with respect to any action or proceeding related
to or arising out of this Agreement, any document executed in connection herewith and the matters contemplated hereby and thereby. 
 21.
No Agreement Until Executed. Irrespective of negotiations among the parties or the exchanging of drafts of this Agreement, this Agreement shall not constitute or be deemed to evidence a contract, agreement, arrangement or understanding
between the parties hereto unless and until (a) the Board of Directors of Zalicus has approved, for purposes of any applicable anti-takeover laws and regulations and any applicable provision of the Zalicus Charter, the transactions contemplated
by the Merger Agreement, (b) the Merger Agreement is executed by all parties thereto, and (c) this Agreement is executed by all parties hereto. 

22. Entire Agreement; Counterparts; Exchanges by Facsimile. This Agreement and the other agreements referred to in this Agreement
constitute the entire agreement and supersede all prior agreements and understandings, both written and oral, among or between any of the parties with respect to the subject matter hereof and thereof. This Agreement may be executed in several
counterparts, each of which shall be deemed an original and all of which shall constitute one and the same instrument. The exchange of a fully executed Agreement (in counterparts or otherwise) by all parties by facsimile or electronic transmission
via “.pdf’ shall be sufficient to bind the parties to the terms and conditions of this Agreement. 

  
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 23. Amendment. This Agreement may not be amended, supplemented or modified, and no
provisions hereof may be modified or waived, except by an instrument in writing signed on behalf of each party hereto. 
 24. Definition
of Merger Agreement. For purposes of this Agreement, the term “Merger Agreement” may include such agreement as amended or modified as long as such amendments or modifications (a) do not (i) change the form of
consideration or (ii) change the Exchange Ratio in a manner adverse to Stockholder, or (b) have been agreed to in writing by Stockholder. 

25. Construction. 

(a) For purposes of this Agreement, whenever the context requires: the singular number shall include the plural, and vice
versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine genders. 

(b) The parties hereto agree that any rule of construction to the effect that ambiguities are to be resolved against the
drafting party shall not be applied in the construction or interpretation of this Agreement. 
 (c) As used in this
Agreement, the words “include” and “including,” and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 

(d) Except as otherwise indicated, all references in this Agreement to “Sections,” “Exhibits” and
“Schedules” are intended to refer to Sections of this Agreement and Exhibits and Schedules to this Agreement, respectively. 

(e) The bold-faced headings contained in this Agreement are for convenience of reference only, shall not be deemed to be a part
of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. 
 [Remainder of
Page has Intentionally Been Left Blank] 

  
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 EXECUTED as of the date first above written. 

 

			
	[STOCKHOLDER]
		
	By:	 	 
	Name:	 	 
	Title:	 	 

  
  

 
  

  
 Signature Page to
Voting Agreement 

 EXECUTED as of the date first above written. 

 

			
	ZALICUS INC.
		
	By:	 	 
	Name:	 	 
	Title:	 	 
	
	EPIRUS BIOPHARMACEUTICALS, INC.
		
	By:	 	 
	Name:	 	 
	Title:	 	 

  
  

 

  
 Signature Page to
Voting Agreement 

 SCHEDULE 1 
  

							
	 Name and Address of Stockholder
	 	 Shares
	 	 Options
	  	 Other Rights

 Schedule of Signatories 

Mark H.N. Corrigan, M.D. 
 Sally W. Crawford 

Frank Haydu 
 William Hunter, M.D. 

Michael Kauffman, M.D. 
 W. James O’Shea 

Justin A. RenzEX-10.2

 Exhibit 10.2 

VOTING AGREEMENT 
 THIS
VOTING AGREEMENT (“Agreement”), dated as of April 15, 2014, is made by and among Zalicus Inc., a Delaware corporation (“Phoenix”), Epirus Biopharmaceuticals, Inc., a Delaware corporation (the
“Company”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of the Company. 

WHEREAS, Phoenix, BRunning, Inc., a Delaware corporation and a wholly owned subsidiary of Phoenix (“Merger Sub”), and
the Company, have entered into an Agreement and Plan of Merger and Reorganization, dated of even date herewith (the “Merger Agreement”), providing for the merger of Merger Sub with and into the Company (the
“Merger”); 
 WHEREAS, Stockholder beneficially owns and has sole or shared voting power with respect to the number
of Shares, and holds stock options or other rights to acquire the number of Shares indicated opposite Stockholder’s name on Schedule 1 attached hereto; 

WHEREAS, as an inducement and a condition to the willingness of Phoenix, Merger Sub and the Company to enter into the Merger Agreement,
and in consideration of the substantial expenses incurred and to be incurred by them in connection therewith, Stockholder has agreed to enter into and perform this Agreement; and 

WHEREAS, all capitalized terms used in this Agreement without definition herein shall have the meanings ascribed to them in the Merger
Agreement. 
 NOW, THEREFORE, in consideration of, and as a condition to, Phoenix’s, Merger Sub’s and the Company’s
entering into the Merger Agreement and proceeding with the transactions contemplated thereby, and in consideration of the expenses incurred and to be incurred by them in connection therewith, Stockholder, Phoenix and the Company agree as follows:

 1. Agreement to Vote Shares. Stockholder agrees that, prior to the Expiration Date (as defined in Section 2 below), at
any meeting of the stockholders of the Company or any adjournment or postponement thereof, or in connection with any written consent of the stockholders of the Company, with respect to the Merger, the Merger Agreement or any Company Acquisition
Proposal, Stockholder shall: 
 (a) appear at such meeting or otherwise cause the Shares and any New Shares (as defined in
Section 3 below) to be counted as present thereat for purposes of calculating a quorum; 
 (b) from and after the
date hereof until the Expiration Date, vote (or cause to be voted), or deliver a written consent (or cause a written consent to be delivered) covering all of the Shares and any New Shares that such Stockholder shall be entitled to so vote:
(i) in favor of adoption and approval of the Merger; (ii) against any action or agreement that, to the knowledge of Stockholder, would reasonably be expected to result in a breach in any material respect of any covenant, representation or
warranty or any 

 
other obligation or agreement of the Company or any of its Subsidiaries or Affiliates under the Merger Agreement or that would reasonably be expected to result in any of the conditions to the
Company’s or any of its Subsidiaries’ or Affiliates’ obligations under the Merger Agreement not being fulfilled; and (iii) against any Company Acquisition Proposal, or any agreement, transaction or other matter that is intended
to, or would reasonably be expected to, impede, interfere with, delay, postpone, discourage or materially and adversely affect the consummation of the Merger and all other transactions contemplated by the Merger Agreement. The Stockholder shall not
take or commit or agree to take any action inconsistent with the foregoing. 
 2. Expiration Date. As used in this Agreement, the
term “Expiration Date” shall mean the earlier to occur of (a) the Effective Time, (b) such date and time as the Merger Agreement shall be terminated pursuant to Section 9 thereof or otherwise, or (c) upon
mutual written agreement of the parties to terminate this Agreement. Upon termination or expiration of this Agreement, no party shall have any further obligations or liabilities under this Agreement; provided, however, such termination
or expiration shall not relieve any party from liability for any willful breach of this Agreement or acts of bad faith prior to termination hereof. 

3. Additional Purchases. Stockholder agrees that any shares of capital stock or other equity securities of the Company that Stockholder
purchases or with respect to which Stockholder otherwise acquires sole or shared voting power after the execution of this Agreement and prior to the Expiration Date, whether by the exercise of any stock options or otherwise (“New
Shares”), shall be subject to the terms and conditions of this Agreement to the same extent as if they constituted the Shares. 

4. Agreement to Retain Shares. From and after the date hereof until the Expiration Date, Stockholder shall not, directly or indirectly,
(a) sell, assign, transfer, tender, or otherwise dispose of (including, without limitation, by the creation of any Liens (as defined in Section 5(c) below)) any Shares, (b) deposit any Shares or New Shares into a voting trust
or enter into a voting agreement or similar arrangement with respect to such Shares or New Shares or grant any proxy or power of attorney with respect thereto (other than this Agreement), (c) enter into any contract, option, commitment or other
arrangement or understanding with respect to the direct or indirect sale, transfer, assignment or other disposition of (including, without limitation, by the creation of any Liens) any Shares or New Shares, or (d) take any action that would
make any representation or warranty of Stockholder contained herein untrue or incorrect or have the effect of preventing or disabling Stockholder from performing Stockholder’s obligations under this Agreement. Notwithstanding the foregoing,
Stockholder may make (a) transfers by will or by operation of law or other transfers for estate-planning purposes, in which case this Agreement shall bind the transferee, (b) with respect to such Stockholder’s Company Options which
expire on or prior to the Expiration Date, transfers, sale, or other disposition of Shares to the Company as payment for the (i) exercise price of such Stockholder’s Company Options and (ii) taxes applicable to the exercise of such
Stockholder’s Company Options, (c) if Stockholder is a partnership or limited liability company, a transfer to one or more partners or members of Stockholder or to an affiliated corporation, trust or other business entity under common
control with Stockholder, or if Stockholder is a trust, a transfer to a beneficiary, provided that in each such case the applicable transferee has signed a voting agreement in substantially the form hereof, (d) to another holder of the capital
stock of the Company that has signed a voting agreement in substantially the form hereof, and (e) as Phoenix may otherwise agree in writing in its sole discretion. 

  
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 5. Representations and Warranties of Stockholder. Stockholder hereby represents and
warrants to Phoenix and the Company as follows: 
 (a) Stockholder has the full power and authority to execute and deliver
this Agreement and to perform Stockholder’s obligations hereunder; 
 (b) this Agreement has been duly executed and
delivered by or on behalf of Stockholder and, to the Stockholder’s knowledge and assuming this Agreement constitutes a valid and binding agreement of the Company and Phoenix, constitutes a valid and binding agreement with respect to
Stockholder, enforceable against Stockholder in accordance with its terms, except as enforcement may be limited by general principles of equity whether applied in a court of law or a court of equity and by bankruptcy, insolvency and similar laws
affecting creditors’ rights and remedies generally; 
 (c) except as set forth on Schedule 1, Stockholder
beneficially owns the number of Shares indicated opposite such Stockholder’s name on Schedule 1, and will own any New Shares, free and clear of any liens, claims, charges or other encumbrances or restrictions of any kind whatsoever
(“Liens”), and has sole or shared, and otherwise unrestricted, voting power with respect to such Shares or New Shares and none of the Shares or New Shares is subject to any voting trust or other agreement, arrangement or restriction
with respect to the voting of the Shares or the New Shares, except as contemplated by this Agreement; 
 (d) to the knowledge
of Stockholder, the execution and delivery of this Agreement by Stockholder does not, and the performance by Stockholder of his or her obligations hereunder and the compliance by Stockholder with any provisions hereof will not, violate or conflict
with, result in a material breach of or constitute a default (or an event that with notice or lapse of time or both would become a material default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, or
result in the creation of any Liens on any Shares or New Shares pursuant to, any agreement, instrument, note, bond, mortgage, contract, lease, license, permit or other obligation or any order, arbitration award, judgment or decree to which
Stockholder is a party or by which Stockholder is bound, or any law, statute, rule or regulation to which Stockholder is subject or, in the event that Stockholder is a corporation, partnership, trust or other entity, any bylaw or other
organizational document of Stockholder; and 
 (e) to the knowledge of Stockholder, the execution and delivery of this
Agreement by Stockholder does not, and the performance of this Agreement by Stockholder does not and will not, require any consent, approval, authorization or permit of, or filing with or notification to, any governmental or regulatory authority by
Stockholder except for applicable requirements, if any, of the Exchange Act, and except where the failure to obtain such consents, approvals, authorizations or permits, or to make such filings or notifications, would not prevent or delay the
performance by Stockholder of his or her obligations under this Agreement in any material respect. 

  
 3 

 6. Irrevocable Proxy. Subject to the penultimate sentence of this Section 6,
by execution of this Agreement, Stockholder does hereby appoint Phoenix with full power of substitution and resubstitution, as Stockholder’s true and lawful attorney and irrevocable proxy, to the fullest extent of the undersigned’s rights
with respect to the Shares, to vote, if the Stockholder is unable to perform his or her obligations under this Agreement, each of such Shares solely with respect to the matters set forth in Section 1 hereof. Stockholder intends this
proxy to be irrevocable and coupled with an interest hereunder until the Expiration Date and hereby revokes any proxy previously granted by Stockholder with respect to the Shares. Notwithstanding anything contained herein to the contrary, this
irrevocable proxy shall automatically terminate upon the Expiration Date of this Agreement. The Stockholder hereby revokes any proxies previously granted and represents that none of such previously-granted proxies are irrevocable. 

7. No Solicitation. From and after the date hereof until the Expiration Date, Stockholder shall not (a) initiate, solicit, seek or
knowingly encourage or support any inquiries, proposals or offers that constitute or may reasonably be expected to lead to, a Company Acquisition Proposal, (b) engage or participate in, or knowingly facilitate, any discussions or negotiations
regarding any inquiries, proposals or offers that constitute, or may reasonably be expected to lead to, a Company Acquisition Proposal, (c) furnish to any Person other than the Company any non-public information that could reasonably be
expected to be used for the purposes of formulating any Company Acquisition Proposal, (d) enter into any letter of intent, agreement in principle or other similar type of agreement relating to a Company Acquisition Proposal, or enter into any
agreement or agreement in principle requiring the Company to abandon, terminate or fail to consummate the transactions contemplated hereby, (e) initiate a stockholders’ vote or action by consent of the Company’s stockholders with
respect to a Company Acquisition Proposal, (f) except by reason of this Agreement, become a member of a “group” (as such term is defined in Section 13(d) of the Exchange Act) with respect to any voting securities of the Company
that takes any action in support of a Company Acquisition Proposal or (g) propose or agree to do any of the foregoing. In the event that Stockholder is a corporation, partnership, trust or other entity, it shall not permit any of its
Subsidiaries or Affiliates to, nor shall it authorize any officer, director or representative of Stockholder, or any of its Subsidiaries or Affiliates to, undertake any of the actions contemplated by this Section 7. 

8. Waiver of Appraisal Rights; No Legal Actions. 

(a) The Stockholder hereby waives, and agrees not to exercise or assert, any appraisal rights under applicable law, including
Section 262 of the DGCL in connection with the Merger. 
 (b) The Stockholder will not in its capacity as a stockholder
of the Company bring, commence, institute, maintain, prosecute or voluntarily aid any Legal Proceeding which (i) challenges the validity or seeks to enjoin the operation of any provision of this Agreement or (ii) alleges that the execution
and delivery of this agreement by the 

  
 4 

 
Stockholder, either alone or together with the other voting agreements and proxies to be delivered in connection with the execution of the Merger Agreement, or the approval of the Merger
Agreement by the Board of Directors of the Company, constitutes a breach of any fiduciary duty of the Board of Directors of the Company or any member thereof. 

9. Other Remedies; Specific Performance. Except as otherwise provided herein, any and all remedies herein expressly conferred upon a
party will be deemed cumulative with, and not exclusive of, any other remedy conferred hereby, or by Law or equity upon such party, and the exercise by a party of any one remedy will not preclude the exercise of any other remedy. The parties hereto
agree that irreparable damage would occur in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to
seek an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions hereof in any court of the United States or any state having jurisdiction, this being the addition to any other remedy to
which they are entitled at Law or in equity. 
 10. Directors and Officers. This Agreement shall apply to Stockholder solely in
Stockholder’s capacity as a stockholder of the Company and/or holder of options to purchase shares of Company Common Stock and/or holder of warrants to purchase shares of Company Common Stock and not in such Stockholder’s capacity as a
director, officer or employee of the Company or any of its Subsidiaries or in such Stockholder’s capacity as a trustee or fiduciary of any employee benefit plan or trust. Notwithstanding any provision of this Agreement to the contrary,
nothing in this Agreement shall (or require Stockholder to attempt to) limit or restrict a director and/or officer of the Company in the exercise of his or her fiduciary duties consistent with the terms of the Merger Agreement as a director and/or
officer of the Company or in his or her capacity as a trustee or fiduciary of any employee benefit plan or trust or prevent or be construed to create any obligation on the part of any director and/or officer of the Company or any trustee or
fiduciary of any employee benefit plan or trust from taking any action in his or her capacity as such director, officer, trustee and/or fiduciary. 

11. No Ownership Interest. Nothing contained in this Agreement shall be deemed to vest in Phoenix any direct or indirect ownership
or incidence of ownership of or with respect to any Shares. All rights, ownership and economic benefits of and relating to the Shares shall remain vested in and belong to Stockholder, and Phoenix does not have authority to manage, direct,
superintend, restrict, regulate, govern, or administer any of the policies or operations of the Company or exercise any power or authority to direct Stockholder in the voting of any of the Shares, except as otherwise provided herein. 

12. Termination. This Agreement shall terminate and shall have no further force or effect as of the Expiration
Date. Notwithstanding the foregoing, nothing set forth in this Section 12 or elsewhere in this Agreement shall relieve either party hereto from any liability, or otherwise limit the liability of either party from any liability for
any intentional breach of any obligation or other provision contained in this Agreement. 
 13. Further Assurances. Stockholder
shall, from time to time, execute and deliver, or cause to be executed and delivered, such additional or further consents, documents and other instruments as the Company or Phoenix may reasonably request for the purpose of effectively carrying out
the transactions contemplated by this Agreement and the Merger Agreement. 

  
 5 

 14. Disclosure. Stockholder hereby agrees that Phoenix and the Company may publish and
disclose in the Registration Statement, any resale registration statement relating thereto (including all documents and schedules filed with the SEC), the Proxy Statement, any prospectus filed with any regulatory authority in connection with the
Merger and any related documents filed with such regulatory authority and as otherwise required by Law, such Stockholder’s identity and ownership of Shares and the nature of such Stockholder’s commitments, arrangements and understandings
under this Agreement and may further file this Agreement as an exhibit to the Registration Statement or prospectus or in any other filing made by Phoenix or the Company as required by Law or the terms of the Merger Agreement, including with the SEC
or other regulatory authority, relating to the Merger, all subject to prior review and an opportunity to comment by Stockholder’s counsel. 

15. Notice. All notices and other communications hereunder shall be in writing and shall be deemed given if delivered personally or
sent by overnight courier (providing proof of delivery) or by facsimile transmission (providing confirmation of transmission) to the Company or Phoenix, as the case may be, in accordance with Section 10.8 of the Merger Agreement and to each
Stockholder at its address set forth on Schedule 1 attached hereto (or at such other address for a party as shall be specified by like notice). 

16. Severability. Any term or provision of this Agreement that is invalid or unenforceable in any situation in any jurisdiction shall
not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or provision in any other situation or in any other jurisdiction. If a final judgment of a
court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the parties hereto agree that the court making such determination shall have the power to limit such term or provision, to delete
specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this Agreement shall be
valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the parties hereto agree to replace such invalid or unenforceable term or provision with a valid and enforceable term or
provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision. 

17. Assignability. This Agreement shall be binding upon, and shall be enforceable by and inure solely to the benefit of, the parties
hereto and their respective successors and assigns; provided, however, that neither this Agreement nor any of a party’s rights or obligations hereunder may be assigned or delegated by such party without the prior written consent of the
other parties hereto, and any attempted assignment or delegation of this Agreement or any of such rights or obligations by such party without the other party’s prior written consent shall be void and of no effect. Nothing in this Agreement,
express or implied, is intended to or shall confer upon any Person (other than the parties hereto) any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. 

  
 6 

 18. No Waivers. No waivers of any breach of this Agreement extended by the Company or
Phoenix to Stockholder shall be construed as a waiver of any rights or remedies of the Company or Phoenix, as applicable, with respect to any other stockholder of the Company who has executed an agreement substantially in the form of this Agreement
with respect to Shares held or subsequently held by such stockholder or with respect to any subsequent breach of the Stockholder or any other such stockholder of the Company. No waiver of any provisions hereof by any party shall be deemed a waiver
of any other provisions hereof by any such party, nor shall any such waiver be deemed a continuing waiver of any provision hereof by such party. 

19. Applicable Law; Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the Laws of the State of
Delaware, regardless of the Laws that might otherwise govern under applicable principles of conflicts of Laws. In any action or proceeding between any of the parties arising out of or relating to this Agreement, each of the parties:
(i) irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Court of Chancery of the State of Delaware or to the extent such court does not have subject matter jurisdiction, the Superior Court of the
State of Delaware or the United States District Court for the District of Delaware, (ii) agrees that all claims in respect of such action or proceeding shall be heard and determined exclusively in accordance with clause (i) of this
Section 19, (iii) waives any objection to laying venue in any such action or proceeding in such courts, (iv) waives any objection that such courts are an inconvenient forum or do not have jurisdiction over any party, and
(v) agrees that service of process upon such party in any such action or proceeding shall be effective if notice is given in accordance with Section 15 of this Agreement. 

20. Waiver of Jury Trial. The parties hereto hereby waive any right to trial by jury with respect to any action or proceeding related
to or arising out of this Agreement, any document executed in connection herewith and the matters contemplated hereby and thereby. 
 21.
No Agreement Until Executed. Irrespective of negotiations among the parties or the exchanging of drafts of this Agreement, this Agreement shall not constitute or be deemed to evidence a contract, agreement, arrangement or understanding
between the parties hereto unless and until (a) the Board of Directors of the Company has approved, for purposes of any applicable anti-takeover laws and regulations and any applicable provision of the Company Charter, the transactions
contemplated by the Merger Agreement, (b) the Merger Agreement is executed by all parties thereto, and (c) this Agreement is executed by all parties hereto. 

22. Entire Agreement; Counterparts; Exchanges by Facsimile. This Agreement and the other agreements referred to in this Agreement
constitute the entire agreement and supersede all prior agreements and understandings, both written and oral, among or between any of the parties with respect to the subject matter hereof and thereof. This Agreement may be executed in several
counterparts, each of which shall be deemed an original and all of which shall constitute one and the same instrument. The exchange of a fully executed Agreement (in counterparts or otherwise) by all parties by facsimile or electronic transmission
via “.pdf’ shall be sufficient to bind the parties to the terms and conditions of this Agreement. 

  
 7 

 23. Amendment. This Agreement may not be amended, supplemented or modified, and no
provisions hereof may be modified or waived, except by an instrument in writing signed on behalf of each party hereto. 
 24. Definition
of Merger Agreement. For purposes of this Agreement, the term “Merger Agreement” may include such agreement as amended or modified as long as such amendments or modifications (a) do not (i) change the form of
consideration or (ii) change the Exchange Ratio in a manner adverse to Stockholder, or (b) have been agreed to in writing by Stockholder. 

25. Construction. 

(a) For purposes of this Agreement, whenever the context requires: the singular number shall include the plural, and vice
versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine genders. 

(b) The parties hereto agree that any rule of construction to the effect that ambiguities are to be resolved against the
drafting party shall not be applied in the construction or interpretation of this Agreement. 
 (c) As used in this
Agreement, the words “include” and “including,” and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 

(d) Except as otherwise indicated, all references in this Agreement to “Sections,” “Exhibits” and
“Schedules” are intended to refer to Sections of this Agreement and Exhibits and Schedules to this Agreement, respectively. 

(e) The bold-faced headings contained in this Agreement are for convenience of reference only, shall not be deemed to be a part
of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. 

[Remainder of Page has Intentionally Been Left Blank] 

  
 8 

 EXECUTED as of the date first above written. 

 

			
	[STOCKHOLDER]
		
	By:	 	 
	Name:	 	 
	Title:	 	 

  
  

 
 Signature Page to Voting Agreement 

 EXECUTED as of the date first above written. 

 

			
	ZALICUS INC.
		
	By:	 	 
	Name:	 	 
	Title:	 	 
	
	EPIRUS BIOPHARMACEUTICALS, INC.
		
	By:	 	 
	Name:	 	 
	Title:	 	 

  
  

 

  
 Signature Page to
Voting Agreement 

 SCHEDULE 1 
  

							
	 Name and Address of Stockholder
	 	 Shares
	 	 Options
	 	 Other Rights

 Schedule of Signatories 

Livzon Mabpharm Inc. 
 Bestow Mind Limited 

5AM Co-Investors III, L.P. 
 5AM Ventures III, L.P. 

Montreux Equity Partners V, L.P. 
 Montreux Equity Partners IV,
L.P. 
 TPG Biotechnology Partners III, L.P. 
 Adage Capital
Management, LLC 
 Amit Munshi 
 Kevin Buchi 

Thomas Shea 
 Kim Seth

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