Document:

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OFFICE LEASE AGREEMENT

400 HAMILTON BUILDING

This Lease is made as of June 13, 2006 (the “Effective Date of Lease”) by and between 400 HAMILTON
ASSOCIATES, a California limited partnership, (hereinafter called “Landlord”), and the individuals
and/or entities as set forth specifically in Subparagraph 1 of the Fundamental Lease Provisions
below, (hereinafter called “Tenant”), and is subject to the terms and conditions set forth below:

FUNDAMENTAL LEASE PROVISIONS

	 	 	 	 	 
	1.

	 	Tenant:
	 	Hercules Technology Growth Capital, Inc., a California corporation
	 
	 	 	 	 
	2.

	 	Notice/Correspondence Address:
	 	400 Hamilton Avenue, Suite 300
	 

	 	 	 	Palo Alto, CA 94301
	 

	 	 	 	Attn: Sally Borg
	 
	 	 	 	 
	3.

	 	Guarantor(s) of Tenant:
	 	None
	 
	 	 	 	 
	4.

	 	Address & Suite #:
	 	400 Hamilton Avenue, Suite 300
	 

	 	 	 	Palo Alto, CA 94301
	 
	 	 	 	 
	 

	 	Gross rentable square feet:
	 	8325 square feet, subject to adjustment pursuant to
Paragraph 8.A
	 
	 	 	 	 
	5.

	 	Tenant’s Pro Rata Share:
	 	8.84%, subject to adjustment pursuant to
Paragraph 8.A
	 
	 	 	 	 
	6.

	 	Management Fee:
	 	Three Percent (3%) of Base Rent
	 
	 	 	 	 
	7.

	 	Commencement Date:
	 	Date of delivery of possession; see Paragraph 2
	 
	 	 	 	 
	8.

	 	Term of Lease:
	 	Approximately Seven (7) years and three months
	 
	 	 	 	 
	 

	 	Expiration Date:
	 	Last day of the month in which the seventh (7th) anniversary of
the Rent Commencement Date occurs
	 
	 	 	 	 
	9.

	 	Monthly Base Rent:
	 	$36,213.75, subject to adjustment pursuant to
Paragraph 8.A
	 
	 	 	 	 
	10.

	 	Rent Commencement Date:
	 	Date on which (i) Landlord’s Architect furnishes a
Certificate of Substantial Completion confirming the
substantial completion of the Tenant Improvements; and (ii) the final building inspection
has been obtained from the City of Palo Alto,
subject to adjustment for Tenant Delay provided in
Exhibit “B”, but in no event later than November 1, 2006.
	 
	 	 	 	 
	11.

	 	Base Rent Adjustment Date:
	 	Each anniversary of the Rent Commencement Date, commencing with
the first anniversary and each year thereafter; if the Rent Commencement Date occurs on a day
other than the first day of a month, the first day of the month in which each anniversary of
the Rent Commencement Date occurs.

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	 	Scheduled Base Rent Adjustments:
	 	Increase of three percent (3%) over Base Rent in the month
preceding the Adjustment Date
	 
	 	 	 	 
	12.

	 	Security Deposit:
	 	[TBD] Total of tenant improvement dollars
contributed by Landlord and brokerage commission
	 
	 	 	 	 
	13.

	 	Tenant Use:
	 	General office purposes and uses incidental thereto
consistent with professional office use and use of
the Building
	 
	 	 	 	 
	14.

	 	Tenant’s Broker:
	 	NAI BT Commercial
	 
	 	 	 	 
	 

	 	Landlord’s Broker:
	 	Cornish & Carey Commercial
	 
	 	 	 	 
	15.

	 	Parking:
	 	33 non-exclusive parking spaces in underground parking garage only, subject to
adjustment pursuant to Paragraph 8.A
	 
	 	 	 	 
	16.

	 	Tenant Improvement Allowance:
	 	Thirty-Five Dollars per useable square foot;
approximately $262,500.00, subject to adjustment
pursuant to Paragraph 8.A
	 
	 	 	 	 
	17.

	 	Option to Extend:
	 	One (1) option to extend for five (5) years

Landlord hereby leases to Tenant and Tenant hereby leases from Landlord those certain Premises
designated in Subparagraph 4 of the Fundamental Lease Provisions above at the 400 Hamilton Building
(the “Building”), located at 400 Hamilton Avenue, Palo Alto, California, as outlined on Exhibit “A”
attached hereto and made a part hereof (the “Premises”). Said Premises comprise a gross rentable
square footage (hereinafter “Rentable Square Footage”) as set forth in Subparagraph 4 of the
Fundamental Lease Provisions. The Building is deemed to contain Ninety-Four Thousand One Hundred
Thirty-One (94131) gross rentable square feet.

The parties hereto agree that said letting is upon and subject to the terms, covenants and
conditions herein set forth and Tenant covenants as a material part of the consideration for this
Lease to keep and perform each and all of said terms, covenants and conditions by it to be kept and
performed and that this Lease is made upon the condition of such performance.

	 	 	 	 	 	 	 
	LANDLORD	 	 	 	TENANT
	400 HAMILTON ASSOCIATES, a	 	 	 	HERCULES TECHNOLOGY GROWTH CAPITAL, INC, a California corporation
	 
	 	 	 	 	 	 
	California limited partnership	 	 	 	 
	By

	 	/s/ Charles J. Keenan III
	 	By:
	 	/s/ Manuel A. Henriquez
	 

	 	 
	 	 	 	 
	 

	 	Charles J. Keenan III, Trustee for the Amended and
Restated Keenan Declaration of Trust dated February 17, 1998,
General Partner
	 	Name:

Title:
	 	Manuel A. Henriquez

Chief Executive Officer and President
	 
	 	 	 	 	 	 
	By

	 	/s/ Mark T. Gates
	 	By:
	 	/s/ David M. Lund
	 

	 	 
	 	 	 	 
	 

	 	Mark T. Gates, Trustee of the Mark T. Gates and Elizabeth W.
Gates Living Trust Agreement dated September 10, 1993,
General Partner
	 	Name:

Title:
	 	David M. Lund

Chief Financial Officer
	 
	 	 	 	 	 	 
	By

	 	/s/ Elizabeth W. Gates	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Elizabeth W. Gates, Trustee of the Mark T. Gates and Elizabeth
W. Gates Living Trust Agreement dated September 10, 1993,
General Partner	 	 	 	 

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OFFICE LEASE AGREEMENT

400 HAMILTON BUILDING

1. TERM. The term of this Lease shall be for that consecutive year period identified in
Subparagraph 8 of the Fundamental Lease Provisions, commencing on the Commencement Date identified
in Subparagraph 7 of the Fundamental Lease Provisions. The Lease shall expire on the Expiration
Date identified in Subparagraph 8 of the Fundamental Lease Provisions, subject to the option to
extend identified in Subparagraph 17 of the Fundamental Lease Provisions.

2. POSSESSION.

     a. Tenant agrees that in the event of the inability of Landlord to deliver possession of the
Premises to Tenant on the anticipated Commencement Date set forth in Subparagraph 7 of the
Fundamental Lease Provisions, this Lease shall not be void or voidable, nor shall Landlord be
liable to Tenant for any loss or damage resulting therefrom. Should Landlord tender possession of
the Premises to Tenant prior to the date specified for commencement of the term hereof, and Tenant
elects to accept such prior tender, such prior occupancy shall be subject to all of the terms,
covenants and conditions of this Lease. Notwithstanding the above, if Landlord does not deliver
possession within three (3) months of the anticipated Commencement Date stated in Subparagraph 7 of
the Fundamental Lease Provisions, Tenant can elect to terminate this Lease by giving written notice
to Landlord within five (5) days after said date, in which case this Lease shall be terminated and
any sums paid or security deposit delivered to Landlord shall be returned to Tenant. However,
delays caused by Force Majeure (defined in Paragraph 40 below) shall extend such three-month period
by the number of days of such delay.

     b. Inasmuch as Tenant is taking the Premises “as is”, possession of the Premises shall be
deemed delivered and the term of this Lease shall commence when Landlord tenders possession of the
Premises to Tenant. Landlord shall tender possession of the Premises to Tenant upon execution of
this Lease, provided that Tenant has delivered to Landlord the prepaid rent and security deposit
provided for in Paragraph 3.f and 3.h below and the Certificate of Insurance provided for in
Paragraph 18.a below.

3. RENT.

     a. Base Rent: Commencing on the Rent Commencement Date set forth in Subparagraph 10
of the Fundamental Lease Provisions, Tenant shall pay to Landlord as monthly Base Rent for the
Premises, in advance and subject to adjustments as provided herein, the sum set forth in
Subparagraph 9 of the Fundamental Lease Provisions on or before the first day of each and every
successive calendar month until that date set forth in Subparagraph 11 of the Fundamental Lease
Provisions above (the “ Adjustment Date”).

     b. Rental Adjustments: The monthly Base Rent provided for in Paragraph 3.a of this
Lease shall be subject to adjustment on each Adjustment Date specified in Subparagraph 11 of the
Fundamental Lease Provisions in the amount of a three percent (3%) increase as specified in said
Subparagraph 11.

     c. Additional Rent: Beginning on the Rent Commencement Date, Tenant shall pay to
Landlord in addition to the Base Rent, as Additional Rent, in accordance with Paragraph 3.c (v)
below, Tenant’s Pro Rata share of the items set forth in paragraphs 3(c)(i)-(iii) below. Tenant’s
Pro Rata Share of such items is equal to the Rentable Square Footage of the Premises divided by the
rentable square footage of the Building. Additional Rent shall include a management fee in the
amount stipulated in Subparagraph 6 of the Fundamental Lease Provisions. Tenant’s Pro Rata Share
is that percentage set

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forth in Subparagraph 5 of the Fundamental Lease
Provisions. Landlord reserves the right to redetermine Tenant’s Pro Rata Share of these
charges calculated on another equitable basis. An equitable adjustment shall be made to Tenant’s
Pro Rata Share of Real Property Taxes for such circumstances as Tenant’s installation of
overstandard tenant improvements which increase the value of the Premises relative to the balance
of the Building and the value of such overstandard improvements are assessed against the entire
Building.

          (i) Taxes. Tenant shall pay to Landlord Tenant’s Pro Rata Share of all Real Property
Taxes assessed against the Building, the parcel or parcels of land on which the Building and other
improvements are located (the “Land”), and other improvements thereon, plus any amount allocated to
the Premises by Landlord as provided below in this Paragraph. The term “Real Property Taxes”, as
used herein, shall mean (a) all taxes, assessments, levies and other charges of any kind or nature
whatsoever, general and special, foreseen and unforeseen (including all installments when due of
principal and interest required to pay any general or special assessments for public improvements
and any increases resulting from reassessments caused by any change in ownership of the Building)
now or hereafter imposed by any governmental or quasi-governmental authority or special district
having the direct or indirect power to tax or levy assessments, which are levied or assessed
against, or with respect to the value, occupancy or use of, all or any portion of the Building (as
now constructed or as may at any time hereafter be constructed, altered, or otherwise changed) or
Landlord’s interest therein, or Landlord’s business of owning and leasing the Building; any
improvements located within the Building; the fixtures, equipment and other property of Landlord,
real or personal, that are an integral part of and located in the Building; public utilities, or
energy within the Building; (b) all charges, levies or fees imposed by reason of environmental
regulation or other governmental control of the Building; and (c) all costs and fees (including
attorneys’ fees) incurred by Landlord in contesting any Real Property Taxes and in negotiating with
public authorities as to any Real Property Taxes. Real Property Taxes shall not include penalties,
interest, or other charges incurred by Landlord due to Landlord’s failure to timely pay Real
Property Taxes. If at any time during the term of this Lease the taxation or assessment of the
Building prevailing as of the Commencement Date of this Lease shall be altered so that in lieu of
or in addition to any Real Property taxes described above there shall be levied, assessed or
imposed (whether by reason of a change in the method of taxation or assessment, creation of a new
tax or charge, or any other cause) an alternate or additional tax or charge (1) on the value, use
or occupancy of the Building or Landlord’s interest therein or (2) on or measured by the gross
receipts, income or rentals from the Building, on Landlord’s business of leasing the Building, or
computed in any manner with respect to the operation of the Building, then any such tax or charge,
however designated, shall be included within the meaning of the term “Real Property Taxes” for
purposes of this Lease. If any Real Property Tax is based in part upon property or rents unrelated
to the Building then only that part of such Real Property Tax that is fairly allocable to the
Premises shall be included within the meaning of the term “Real Property Taxes.” Notwithstanding
the foregoing, the term “Real Property Taxes” shall not include estate, inheritance, gift or
franchise taxes of Landlord, the federal or state net income tax imposed on Landlord’s income from
all sources, documentary or other transfer, or succession taxes.

Tenant shall be liable for and shall pay ten (10) days before delinquency, taxes levied against any
personal property or trade fixtures placed by Tenant in or about the Premises. If any such taxes
on Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property
or if the assessed value of the Building is increased by the inclusion therein of a value placed
upon such personal property or trade fixtures of Tenant and if Landlord, after written notice to
Tenant, pays the taxes based on such increased assessment, which Landlord shall have the right to
do regardless of the validity thereof, but only under proper protest if requested by Tenant, Tenant
shall upon demand, repay to Landlord the taxes so levied against Landlord, or the proportion of
such taxes resulting from such increase in the assessment; provided that in any such event Tenant
shall have the right, in the name of Landlord and with Landlord’s full cooperation, to bring suit
in any court of competent jurisdiction to

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recover the amount of any such taxes so paid under protest, and any amount so recovered shall
belong to Tenant.

          (ii) Property Insurance. Landlord shall purchase and keep in force a policy or
policies of (1) commercial general liability insurance, (2) fire and property damage insurance
including provision for the payment of deductibles and pre-payment for coverage, up to one year,
covering loss or damage to the Building, the Common Areas, and Premises (excluding any tenant
improvements or alterations installed by Tenant) in the amount of the full replacement value
thereof, insuring direct physical loss or damage included within the “special form” classification
of coverage, (3) flood and/or earthquake insurance, if available, with deductible selected by
Landlord in its discretion and rental income insurance in the amount of one hundred percent (100%)
of eighteen (18) months Base and Additional Rent. Tenant shall pay to Landlord Tenant’s Pro Rata
Share of the cost of such a policy or policies of insurance. If such insurance cost is increased
due to Tenant’s use of the Premises, Tenant agrees to pay to Landlord the full cost of such
increase. Tenant shall have no interest in nor any right to the proceeds of any insurance procured
by Landlord for the Premises.

          (iii) Expenses of Operation, Management and Maintenance of the Building and Common
Areas. As Additional Rent, Tenant shall pay to Landlord its Pro Rata Share of all expenses of
owning, operating, managing, maintaining and repairing the Building and Common Areas (“Operating
Expenses”), including, but not limited to, license, permit, and inspection fees; security; all
charges incurred in the maintenance, repair, and replacement of the Common Areas, including parking
lots, sidewalks, driveways, landscaping, parking garage; maintenance, repair and replacement of all
fixtures, elevators, electrical, mechanical, and plumbing systems, roof, plate glass, glazing and
exterior surfaces of the Building; salaries and employee benefits of janitorial personnel and
payroll taxes directly applicable thereto; Common Area Operating Expenses accounting fee paid to
the Building management company; supplies, materials, equipment and tools; insurance deductibles
(provided that the amount of a deductible for flood or earthquake insurance in excess of the
deductible for the property damage insurance policy shall be amortized over a fifteen (15) year
period with interest at the rate specified below in this paragraph on the unamortized balance); the
cost of capital expenditures (1) intended to reduce Operating Expenses or to modernize or otherwise
improve the efficiency of Building systems, or (2) required to comply with existing laws or future
laws of general applicability (but excluding costs to correct any violations existing as of the
Commencement Date, any compliance required to have been done prior to the Commencement Date and any
compliance within individual tenant spaces), provided, however, that in the event Landlord makes
such capital improvements, Landlord shall amortize its investment over the useful life of said
improvements (together with interest at the rate of twelve (12%) percent per annum on the
unamortized balance).

“Operating Expenses” as used herein shall not include Landlord’s debt repayments; interest on real
property indebtedness; expenses directly or indirectly incurred by Landlord for the benefit of any
other tenant: cost for the installation of partitioning or any other tenant improvements; cost of
attracting tenants (including brokerage commissions, advertising expenses, free rent or other
inducements); costs of negotiating leases with tenants or prospective tenants or of enforcing
leases; depreciation on the Building or Common Areas; interest on debt encumbering the Building;
executive salaries or expenses thereof; legal expenses for disputes with tenants and professional
fees incurred outside the normal course of maintenance and operation of the Building and Common
Areas; expenses for repair or replacement paid by warranty, insurance, litigation, settlement or
condemnation proceeds; expenses incurred in remediating environmental contamination; repairs or
replacements caused by Landlord’s gross negligence or the negligence of its agents, employees or
contractors; costs incurred due to the violation by Landlord or any tenant of the Building of the
terms of any lease, encumbrance or law, rule
or regulation applicable to the Building or Common Areas; charitable or political contributions;
acquisition of art unless legally required; costs of selling or mortgaging Landlord’s interest in the

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Building; costs relating to the enforcement of any lease except for provisions for the benefit
of Building tenants generally; costs relating to the defense of Landlord’s title or interest in the
Land or Building; or relating to the negotiation and preparation of tenant leases and related
documents; rent and other payments pursuant to any ground or underlying lease; amortization except
as specifically allowed in the preceding paragraph; costs of items for which a tenant (including
Tenant) reimburses Landlord or pays third parties; costs incurred by Landlord to the extent that
Landlord is reimbursed by governmental entities; Landlord’s general corporate and administrated
expenses, including Landlord’s general accounting fees and expenses for capital improvements to the
Building or Common Areas, except as specifically allowed under the preceding paragraph.

          (iv) Utilities of the Building. As Additional Rent, Tenant shall pay its Pro Rata
Share of the cost of all utility charges such as water, gas, electricity, telephone, and other
electronic communications service, sewer service, waste pick-up and any other utilities, materials
or services furnished directly to the Building, including, without limitation, any temporary or
permanent utility surcharge or usage penalties (including water use penalties imposed by any
regulatory authority) or other exactions whether currently in effect or hereafter imposed.
Landlord shall have the right in its judgment to equitably adjust Tenant’s Pro Rata Share of
utility charges if Landlord reasonably determines that Tenant is using a disproportionate amount of
any utility service not separately metered. Tenant shall be solely responsible for the payment of
all electricity, telephone, telex, water, gas or other utility service used within the Premises and
separately metered to the Premises.

Landlord shall not be liable for and Tenant shall not be entitled to any abatement or reduction of
rent by reason of any interruption or failure of utility services to the Premises when such
interruption or failure is caused by Force Majeure as defined in Paragraph 40 below.

          (v) Payment. The Additional Rent due hereunder shall be paid to Landlord within
thirty (30) days after presentation of invoice from Landlord setting forth such Additional Rent.
At the option of Landlord, Tenant shall pay to Landlord monthly, in advance, Tenant’s Pro Rata
Share of an amount estimated by Landlord to be Landlord’s approximate average monthly expenditures
for Additional Rent items. Landlord shall deliver Landlord’s estimate of such average monthly
expenditures for the following year on or before December 1 of each year, and Tenant shall pay
Tenant’s Pro Rata Share of the estimate monthly in advance during such calendar year. Prior to
April 30 of each year, Landlord shall deliver to Tenant a reconciliation comparing the estimated
amount for Additional Rent for the previous calendar year to Landlord’s actual expenditures for
said Additional Rent items for such calendar year. Tenant shall pay to Landlord, within fifteen
(15) days after demand, any amount of actual expenses expended by Landlord in excess of said
estimated amount, or, providing that Tenant is not in default under this Lease, Landlord shall
credit against subsequent monthly Base Rent or Additional Rent or refund to Tenant (if this Lease
has expired), providing Tenant is not in default under this Lease, any amount of estimated payments
made by Tenant in excess of Landlord’s actual expenditures for said Additional Rent items.

No more often than annually, Tenant may cause a review of Landlord’s calculation and determination
of Additional Rent on the following terms and conditions:

Tenant must request such review within ninety (90) days after delivery of the annual reconciliation
by Landlord and must specifically designate the fiscal year(s) that Tenant intends to review, which
shall be a year within two (2) years of the date of the review but such year must be within the
Term of this Lease; and

Such review will be conducted only during regular business hours at the office where Landlord
maintains Operating Expense records and only after Tenant gives Landlord thirty (30) days notice.
Such review shall be conducted on a non-contingency fee basis, by an independent accountant of

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Tenant’s selection, and if the statements of reconciliation as provided and previously made by
Landlord to Tenant are found to be equal to or less than the amount of one hundred five percent
(105%) of the figure determined by the review, then Tenant shall immediately pay the reasonable
cost of such review and Landlord’s costs (including charges to Landlord by the property manager for
the Building); otherwise the reasonable cost of such review shall be paid for by Landlord.

Tenant shall deliver to Landlord a copy of the results of such review within fourteen (14) days of
its receipt by Tenant, but in any event no later than sixty (60) days after commencement of the
review. No such review shall be conducted if any other tenant has conducted a review for the time
period Tenant intends to review and Landlord furnishes to Tenant a copy of the results of such
review. No review shall be conducted at any time that an Event of Default (defined in Paragraph 21
below) exists on the part of Tenant. No subtenant shall have any right to conduct a review and no
assignee shall conduct a review for any period during which such assignee was not in possession of
the Premises.

The respective obligations of Landlord and Tenant under this paragraph shall survive the expiration
or other termination of this Lease, and if the term hereof shall expire or shall otherwise
terminate on a day other than the last day of a calendar year, the actual Additional Rent incurred
for the calendar year in which the term hereof expires or otherwise terminates shall be determined
on the basis of the statement of actual Additional Rent for such calendar year and shall be
prorated in the proportion which the number of days in such calendar year preceding such
expiration/termination bears to Three Hundred Sixty Five (365).

     d. Partial Month: In the event that the term of this Lease commences on a date other
than the first day of a calendar month, on the date of commencement of the term hereof Tenant shall
pay to Landlord, as rent for the period from such date of commencement to the first day of the next
succeeding calendar month, that proportion of the monthly rent hereof which the number of days
beyond such date of commencement and the first day of the next succeeding calendar month bears to
thirty (30). In the event that the term of this Lease, for any reason, ends on a date other than
the last day of a calendar month, on the first day of the last calendar month of the term hereof,
Tenant shall pay to Landlord, as rent for the period from said first day of the last calendar month
to and including the last calendar day of the term hereof, that proportion of the monthly rent
hereof which the number of days beyond said first day of said last calendar month and the last day
of the term hereof bears to thirty (30).

     e. Late Charge: Tenant hereby acknowledges that late payment by Tenant to Landlord of
Base Rent and Additional Rent and other sums due hereunder will cause Landlord to incur costs not
contemplated by this Lease, the exact amount of which is extremely difficult to ascertain. Such
costs include but are not limited to: administrative, processing, accounting, and late charges
which may be imposed on Landlord by the terms of any contract, revolving credit, mortgage, or trust
deed covering the Premises. Accordingly, if any installment of Base Rent or Additional Rent or
other sum due from Tenant shall not be received by Landlord or its designee when due, Tenant shall
pay to Landlord, as Additional Rent, a late charge equal to two percent (2%) of such overdue amount
in addition to such overdue amount, which late charge shall be due on the same date that the
overdue amount was due. The Parties agree that such late charge represents a fair and reasonable
estimate of the costs Landlord will incur by reason of late payment by Tenant. If any amount due
from Tenant to Landlord remains delinquent for a period in excess of five (5) days, then in
addition to such late charge, Tenant shall pay to Landlord interest on such amount not paid when
due at the Agreed Interest Rate specified in Paragraph 45 from the date such amount became due
until paid. Acceptance by Landlord of such late charge shall not constitute a waiver of any of
Landlord’s rights and remedies granted hereunder. In the event that a late charge is due hereunder,
whether or not collected, for three (3) installments of Base Rent in any twelve (12) month period,
then the Base Rent and Additional Rent shall automatically become due and payable quarterly in
advance, rather than monthly, payable by bank wire/ACH payment or cashier’s check, notwithstanding
any provision of this Lease to the contrary.

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     f. Initial Payment of First Month’s Rent: Upon execution of this Lease, Tenant shall
pay to Landlord (i) the monthly Base Rent stated in Subparagraph 9 of the Fundamental Lease
Provisions above constituting Base Rent for the first (1st) month of the term following the Rent
Commencement Date and (ii) the first months Additional Rent.

     g. Payment of Rents: All Base Rent, Additional Rent, and other sums due hereunder
shall be paid to Landlord, without deduction or offset, in lawful money of the United States of
America, either to the Landlord at:

700 Emerson Street, Palo Alto, California 94301

or by electronic wire transfer directly to Landlord’s bank, or to such other person or to such
other place as Landlord may, from time to time, designate in writing.

     h. Security Deposit: Concurrently with Tenant’s execution of this Lease, Tenant shall
deposit with Landlord the sum identified in Subparagraph 12 of the Fundamental Lease Provisions
above as the Security Deposit. Said sum shall be held by Landlord as a security for the faithful
performance by Tenant of all of the terms, covenants, and conditions of this Lease to be kept and
performed by Tenant during the term hereof. At Tenant’s election, such Security Deposit may be in
the form of an irrevocable standby letter of credit issued by a bank reasonably approved by
Landlord and in form approved by Landlord (“Letter of Credit”). The Letter of Credit shall be
transferable at Tenant’s cost to a successor or successors of Landlord any number of times in its
entirety by notice of assignment from the then holder of the Letter of Credit. Upon the occurrence
of an Event of Default by Tenant, or if the Letter of Credit is not renewed or replaced thirty (30)
days prior to expiration, Landlord may from time to time draw upon the Letter of Credit in whole or
in part and hold the proceeds as a cash Security Deposit. Landlord may, but shall not be mandated
to use, apply or retain all or any part of this Security Deposit for the payment of any amount
which Landlord may spend by reason of Tenant’s default or to compensate Landlord for any other loss
or damage which Landlord may suffer by reason of Tenant’s Event of Default. If any portion of said
Security Deposit is so used or applied, Tenant shall, within ten (10) days after written demand
therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its
original amount. Tenant’s failure to do so shall be a material breach of this Lease. Landlord
shall not be required to keep this Security Deposit separate from its general funds, and Tenant
shall not be entitled to interest on such Security Deposit. If an Event of Default shall occur
more than three (3) times in the payment of Base Rent or Additional Rent in any twelve month
period, irrespective of whether or not such default is cured, then Tenant shall deliver to Landlord
an additional Security Deposit within ten (10) days after demand by Landlord in an amount equal to
three (3) times the Base Rent and Additional Rent. If Tenant fully and faithfully performs every
provision of this Lease to be performed by it, the Security Deposit or any balance thereof shall be
returned to Tenant, or Tenant’s assignee if applicable, within thirty (30) days after the
expiration of the Lease term and Tenant has vacated the Premises.

     i. Rent Definition. All Real Property Taxes, insurance, Operating Expenses, late
fees, charges, interest, and other sums which Tenant is required to pay to Landlord under the terms
of this Lease (together with all interest and penalties that may accrue in the event of Tenant’s
failure to pay such charges) and all damages, costs and expenses which Landlord may incur by reason
of any default by Tenant shall be deemed to be “Additional Rent” under the terms of this Lease.
Landlord shall have all of the same rights and remedies with respect to the non-payment
of Additional Rent as Landlord has for the non-payment of Base Rent. The term “Rent” and
“rent” as used in this Lease are interchangeable terms and shall mean Base Rent and Additional
Rent.

4. USE. Tenant shall use the Premises for the purpose set forth in Subparagraph 13 of the
Fundamental Lease Provisions above and no other purpose and Tenant shall not use or occupy the
Premises in violation of law or of the certificate of occupancy issued for the Premises and shall,
upon

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five (5) days’ written notice from Landlord, discontinue any use of the Premises which is to
be a violation of the use authorized above, law, or of said certificate of occupancy. The Premises
shall not be used by Tenant or any subtenant or licensee for any business purpose where the primary
business is residential real estate brokerage or real estate title or escrow services nor in
violation of any exclusivity right of other tenants of the Building granted by Landlord prior to
the date of this Lease. Tenant shall comply at its sole expense with any statute, rule, regulation,
order or direction of any governmental authority having jurisdiction, which shall by reason of the
nature of Tenant’s particular use or occupancy of the Premises impose any duty upon Tenant or
Landlord with respect to the Premises, or with respect to the use or occupation thereof. Landlord
shall comply with any statute, rule, regulation, order or direction of any governmental authority
having jurisdiction which imposes any duty upon Landlord or Tenant with respect to the physical
condition of the Premises which would be applicable to all general office users and which are not
the result of Tenant’s particular use of the Premises. Costs of Landlord’s compliance may be
treated as Operating Expenses as provided in Paragraph 3 above. Tenant shall not do or permit to
be done anything which will invalidate or increase the cost of any fire, extended coverage or any
other insurance policy covering the Premises and/or property located therein. Tenant shall, at its
sole cost, comply with all requirements of any insurance company or organization necessary for the
maintenance of reasonable fire and public liability insurance covering the Premises and
appurtenances. Tenant shall promptly upon demand reimburse Landlord for any additional premium
charged for such policy by reason of Tenant’s failure to comply with the provisions of this
Paragraph. Tenant shall not use or allow the Premises to be used for any improper, immoral,
unlawful or objectionable purpose, nor shall Tenant cause, maintain or permit any nuisance in, on
or about the Premises. Tenant shall not commit or suffer to be committed any waste in or upon the
Premises.

5. NOTICES. Any notice required or permitted to be given hereunder must be in writing and
may be given by personal delivery or by mail, and if given by mail shall be deemed sufficiently
given three (3) days after being sent by registered or certified mail, or one day after being sent
by overnight mail for guaranteed next-day delivery by a nationally recognized overnight courier
service which guarantees overnight delivery, addressed to Tenant at the addresses set forth in
Subparagraph 2 of the Fundamental Lease Provisions, or to Landlord at the address of Landlord set
forth in Paragraph 3.g. Either party may by written notice to the other specify a different
address for notice purposes except that the Landlord may in any event use the Premises as Tenant’s
address for notice purposes.

6. BROKERS. Tenant and Landlord each represents and warrants to the other that it has had
no dealings with any real estate broker or agent in connection with the negotiation of this Lease,
other than any individuals or entities identified in Subparagraph 14 of the Fundamental Lease
Provisions above (“Brokers”), and that neither Landlord nor Tenant knows of no other real estate
broker or agent who is, or might be, entitled to a commission in connection with this Lease.
Landlord and Tenant each agree to indemnify and defend the other against and hold the other
harmless for any and all claims, demands, losses, liabilities, lawsuits, judgments, costs and
expenses (including without limitation reasonable attorney’s fees) with respect to any leasing
commission or equivalent compensation alleged to be owing on account of any dealings with any real
estate broker or agent, other than the Brokers, occurring by, through, or under the indemnifying
party. Landlord shall be responsible for payment of any brokerage commissions to the Brokers in
connection with this Lease.

7. HOLDING OVER. If Tenant holds over after the expiration or earlier termination of the
term hereof without the express written consent of Landlord, Tenant shall become a tenant at
sufferance only, at one hundred fifty percent (150%) of the Base Rent in effect upon the date of
such expiration plus all other amounts payable by Tenant under this Lease. Any holding over shall
otherwise be on the terms and conditions herein specified, except those provisions relating to the
Lease Term and any options to extend or renew, which provisions shall be of no further force and
effect following the expiration of the applicable exercise period. Tenant shall indemnify, defend,
and hold Landlord harmless from all loss or liability (including, without limitation, any loss or
liability resulting from any

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claim against Landlord made by any succeeding tenant) resulting from
Tenant’s failure to timely surrender the Premises to Landlord and losses to Landlord due to lost
opportunities to lease the Premises to succeeding tenants. Acceptance by Landlord of rent after
such expiration or earlier termination shall not constitute a holdover hereunder or result in a
renewal. The foregoing provisions of this paragraph are in addition to and do not affect
Landlord’s right of re-entry or any other rights of Landlord hereunder or as otherwise provided by
law.

8. CONDITION OF PREMISES.

     A. Landlord shall deliver the Premises to Tenant in shell condition, with demising walls,
corridor, and suite entry completed. Tenant is leasing the Premises “as-is”, without any other
obligation on Landlord’s part to alter, remodel, improve or decorate any part of the Premises or
the Building or Common Areas other than demising the Premises. Tenant will build out tenant
improvements according to the terms of the Work Letter attached hereto as Exhibit “B” (“Work
Letter”). Landlord shall provide the sum identified in Subparagraph 16 of the Fundamental Lease
Provisions above as a Tenant Improvement Allowance in accordance with the Work Letter, which sum
shall be reduced or increased after calculation of the square footage of the Premises as provided
below.

     Landlord shall, after Tenant’s approval of architectural drawings for the Tenant Improvements,
calculate the useable square footage of the Premises and the Common Area located on the third floor
from the approved drawings and calculate the rentable square footage of the Premises. The rentable
and useable square footage shall be determined in accordance with the standards promulgated by the
Building Owners and Managers Association (“BOMA Standard”) as determined by Landlord’s architect
for the Building (“Landlord’s Architect”). The Tenant Improvement Allowance stated in Subparagraph
16 of the Fundamental Lease Provisions shall be determined by the calculation of usable square
footage described above. The rentable square footage stated in Subparagraph 4 of the Fundamental
Lease Provisions, Tenant’s pro rata share stated in Subparagraph 5, monthly Base Rent stated in
Subparagraph 9, and parking stated in Subparagraph 15 shall be adjusted according to the. Landlord
shall provide to Tenant a statement from Landlord’s Architect of the usable square footage and of
the rentable square footage after completion of each such calculation. After calculation of the
square footage of the Premises, Landlord shall deliver to Tenant a Square Footage Statement
substantially in the form of Exhibit “C” attached hereto. The calculation described above affect
only the usable square footage and rentable square footage of the Premises, and the square footage
of the Building for purposes of this Lease shall remain as stated in the grammatical paragraph
following the numbered subparagraphs of the Fundamental Lease Provisions.

     Monthly Base Rent shall be recalculated based on $4.35 per rentable square foot. If the Base
Rent after calculation of the square footage of the Premises is greater than $36,213.75, Landlord
shall deliver an invoice to Tenant for the difference and Tenant shall pay the additional Base Rent
due within ten (10) days after receipt of the invoice. If the Base Rent after calculation of the
square footage of the Premises is less than $36,213.75, Landlord shall credit the excess payment
against the next installments of Base Rent due from Tenant to Landlord.

     Parking shall be recalculated based on the calculated rentable square footage multiplied by
four parking stalls per one thousand square feet; if the product of the multiplication is not a
whole number, the result shall be rounded down to the nearest whole number.

     B. Landlord represents and warrants that on the Commencement Date the Building Common Areas
described in Paragraph 14 below, and Building structural components, Building systems, including
without limitation the roof, plumbing, electrical and HVAC systems, and the Building parking
garage, landscaping plantings and irrigation system, and exterior lighting shall be in good
condition and repair, except as specifically provided in this Paragraph. In the event that a
breach of the foregoing representation and warranty is discovered within thirty (30) days following
the Rent

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Commencement Date, Landlord shall repair or cure such condition at Landlord’s sole cost
and expense (the costs of which shall not be passed through to Tenant pursuant to Paragraph 3);
provided, however, that if Tenant fails to notify Landlord of such breach within said thirty (30)
day period then the costs of any repair or cure of such condition shall be determined in accordance
with the provisions of paragraph 3. Tenant acknowledges that on the date of execution of this
Lease, water intrusion may occur in the Premises from decking on the floor immediately above.
Landlord shall use diligent efforts to locate and repair the decking area which causes such water
intrusion to occur, and Landlord shall throughout the term of this Lease, at Landlord’s cost,
diligently abate any such water intrusion. Landlord also represents and warrants that as of the
Commencement Date the Building, Common Areas, and Building systems shall be in compliance with
then-effective and required provisions of law. Tenant acknowledges that neither Landlord nor any
agent of Landlord has made any representation or warranty with respect to the Premises or with
respect to suitability for the conduct of Tenant’s business unless expressly set forth in this
Lease. Tenant’s failure to notify Landlord with the thirty (30) day period described above of any
defect in the Premises shall conclusively establish that the Premises were at such time in
satisfactory condition, in accordance with the requirements of this Lease, and in good order,
condition, and repair. It is understood and agreed that no provision of the Lease shall be
construed as obligating Landlord to perform any repairs, alterations, or decorations except as
otherwise expressly agreed herein to be performed by Landlord.

9. ALTERATIONS. Tenant shall make no alterations, decorations, additions or improvements
(“Tenant Work”) in or to the Premises without Landlord’s prior written consent, and then by
contractors or materialmen approved by Landlord. Tenant agrees that there shall be no construction
or partitions or other obstructions which might interfere with Landlord’s free access to mechanical
installations or service facilities of the Premises or interfere with the moving of Landlord’s
equipment to or from the enclosures containing said installations or facilities. All Tenant Work
shall be done at such times and in such manner as Landlord may from time to time designate in a
manner to avoid interference with other tenant’s business. Tenant covenants and agrees that all
Tenant Work done by Tenant shall be performed in full compliance with all laws, rules, orders,
ordinances, directions, regulations and requirements of all governmental agencies, offices,
departments, bureaus and boards having jurisdiction. Before commencing any Tenant Work, Tenant
shall give Landlord at least five (5) days’ written notice of the proposed commencement of such
Tenant Work and shall, if required by Landlord, secure at Tenant’s own cost and expense a
completion and lien indemnity bond for such Tenant Work costing in excess of $100,000.00,
satisfactory to Landlord, for such Tenant Work. Tenant further covenants and agrees that any
mechanic’s lien filed against the Premises for work claimed to have been done for, or materials
claimed to have been furnished to, Tenant, will be discharged by Tenant, by bond or otherwise,
within thirty (30) days after receipt of notification of the filing thereof, at the cost and
expense of Tenant. All alterations, decorations, additions or improvements upon the Premises made
by either party, including (without limiting the generality of the foregoing) all wall coverings,
built-in cabinet work, paneling and the like, shall (unless Landlord elects otherwise) become the
property of Landlord and shall remain upon, and be surrendered with, the Premises, as a part
thereof, at the end of the term hereof, except that Landlord may, by written notice to Tenant,
require Tenant to remove all partitions, cabinet work, paneling, counters, railings and
the like installed by Tenant, and Tenant shall repair or, at Landlord’s option, shall pay to the
Landlord all costs arising from such removal.

All personal property, office machinery and equipment, furniture and moveable partitions and other
furnishings, fixtures, and equipment owned by Tenant or installed by Tenant at its expense in the
Premises (collectively, “Tenants FF&E”) shall be and remain the property of Tenant and may be
removed by Tenant at any time during the Term so long as no Event of Default exists hereunder.
Upon expiration or earlier termination of this Lease, Tenant shall remove all Tenant’s FF&E from
the Premises. At Landlord’s election, Tenant shall remove all data, telephone, and other cabling
installed in the Premises or Building by Tenant. If Tenant shall fail to remove all Tenant’s FF&E
from the Premises upon expiration or termination of this Lease for any cause whatsoever, Landlord
may, at its option, remove the same in any manner that Landlord shall choose, and store said
effects without

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liability to Tenant for loss thereof, and Tenant agrees to pay Landlord upon demand
any and all expenses incurred in such removal and/or disposal thereof, including court costs and
attorneys’ fees and storage charges on such effects for any length of time that the same shall be
in Landlord’s possession; or Landlord may, at its option, sell or otherwise dispose of said
effects, or any of the same, in accordance with law for such price as Landlord may obtain and apply
the proceeds of such sale upon any amounts due under this Lease from Tenant to Landlord and upon
the expenses incident to the removal and sale of said effects.

10. REPAIRS. Tenant shall, at Tenant’s sole cost and expense, keep the Premises and every
part thereof in a high standard of maintenance and repair and in good and sanitary condition and
repair, ordinary wear and tear excepted. Tenant shall, upon the expiration or sooner termination
of the term hereof, surrender the Premises to Landlord in the condition existing upon completion of
Tenant’s initial Tenant Improvements and in broom clean condition, ordinary wear and tear excepted.

11. MAINTENANCE BY LANDLORD. Landlord shall maintain in good condition and repair and
subject to reimbursement by Tenant as Additional Rent, if specified in Paragraph 3(c)(iii): a) the
structural portions of the Building, including the foundation, sub-flooring, floor slabs, walls,
roof, and utilities outside the exterior of the Building or in the Building foundation; b) the roof
membrane and exterior wall surfaces; c) all Common Areas, including vertical shaft and distribution
stubouts to the exterior of the Premises, landscaping, and service areas, and Building Systems
(including elevator, plumbing, HVAC, mechanical, electrical, security, power, and life safety),
provided that Landlord shall maintain the plumbing, HVAC, mechanical, electrical, security, and
life safety systems only to the point of distribution to the Premises. Tenant shall promptly
notify Landlord in writing of any items which Tenant is aware require maintenance. Landlord shall
not be liable for any failure to make repairs or perform any maintenance unless such failure shall
continue for an unreasonable time under the circumstances after written notice of need for repairs
is given Landlord. Tenant hereby waives all rights under, and benefits of Subsection 1 of Sections
1932, 1941 and 1942 of the California Civil Code and under any similar law, statute or ordinance
now or hereafter in effect concerning Landlord’s obligation of tenantability or Tenant’s right to
make repairs and deduct the cost of such repairs from rent.

12. ENTRY BY LANDLORD. Landlord reserves and shall at any and all times have the right to
enter the Premises at reasonable business hours, upon giving twenty four (24) hours written or oral
notice to Tenant if Tenant is not otherwise in default hereunder; to inspect the same, to submit
said Premises to prospective purchasers or tenants (during the last nine (9) months of the Term for
prospective tenants), to post notices of nonresponsibility, to alter, improve or repair the
Premises, except in the event of an emergency for which notice will not be required, all without
being deemed guilty of an eviction of Tenant and without abatement of rent, and may erect
scaffolding and other necessary structures where reasonably required by the character of the work
to be performed, provided that the business of the Tenant shall be interfered with as little as is
reasonably practicable. Tenant hereby waives any claim for damages for any injury or inconvenience
to or interference with Tenant’s business, any loss of occupancy or quiet enjoyment of the
Premises, and any other loss occasioned thereby in Landlord’s exercise of rights reserved in the
preceding sentence. For each of the aforesaid purposes, Landlord may, as agreed to by Landlord and
Tenant retain a key with which to unlock all of the doors in, upon and about the Premises,
excluding Tenant’s vaults and safes, and Landlord shall have the right to use any and all means
which Landlord may deem proper to open said door in an emergency in order to obtain entry to the
Premises, and any entry to the Premises obtained by Landlord in the event of an emergency shall not
under any circumstances be construed or deemed to be a forcible or unlawful entry into, or a
detainer of, the Premises, or an eviction of Tenant from the Premises or any portion thereof, and
any damages caused on account thereof shall be paid by Tenant.

13. BUILDING SERVICES & UTILITIES. Landlord shall provide the following standards for
utilities and services, subject to reimbursement by Tenant, as herein above stipulated. Landlord
reserves the right to adopt nondiscriminatory modifications and additions hereto as Landlord deems
necessary.

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     A. Air-Conditioning: The building schedule for heating and air-conditioning shall be
Monday through Friday from 8:00 AM to 6:00 PM and Saturday 9:00 AM to 5:00 PM.

          (i) After Hours Use: Premises shall be supplied with an After Hours Over-ride that
will allow tenant continuing heating and air-conditioning. This use will be separately metered and
Tenant will be directly charged for any after-hours use of the HVAC system. The charge for
after-hours usage shall be at Landlord’s cost therefor, as determined by Landlord in its reasonable
judgment including (1) the cost of electricity at the rate charged by Palo Alto Utilities, (2)
allocated costs of repair and maintenance, (3) depreciation and wear and tear of the HVAC
equipment. The estimated cost to be charged for After Hours Use in the Premises in calendar year
2006 is $12.00 per hour, subject to reconciliation as provided in Paragraph 3.C (v).

     B. Janitorial Service: The Premises shall be provided with five (5) days per week
janitorial service which shall include once a year interior window washing and once a year carpet
cleaning. No one other than persons approved by Landlord shall be permitted to enter the Premises
for such purposes. Tenant shall pay to Landlord the cost of removal of any of Tenant’s recycling,
refuse, and rubbish, to the extent that the same exceeds the recycling, refuse and rubbish usually
and normally attendant upon the use of the Premises as offices.

     C. Security Systems; Access: The building elevators and underground parking garage
lock down to general access from 5 PM to 7 AM Monday through Friday and all day on Saturday and
Sunday. The elevators and the garage security gates are equipped for after-hours controlled
access. A parking access card will be needed at all times for vehicular entry to and exit from the
parking garage. Tenant shall be provided an appropriate number of access instruments for its
personnel at a rate of $10.00 per instrument or the then charge established from time to time by
Landlord.

14. COMMON AREAS. Tenant shall have the non-exclusive right, in common with other tenants
of the Building, to the use of common entrances, hallways, parking areas (excluding on-grade
non-handicapped parking spaces), elevators, corridors, stairways, restrooms, walkways, driveways,
loading docks, ramps, stairs and similar access and service ways and common areas in and adjacent
to the Building generally made available by Landlord to occupants of the Building (“Common Areas”),
subject to such nondiscriminatory rules and regulations as may be adopted by Landlord and attached
hereto as Exhibit “D” and made a part hereof.

15. INDEMNIFICATIONS AND WAIVER. Tenant hereby assumes all risk of damage to property or
injury to persons in, upon or about the Premises or Building from any cause whatsoever and agrees
that Landlord, its partners, and its agents, employees, property managers and independent
contractors (individually, a “Landlord Party” and collectively, “Landlord Parties”) shall not be
liable for, and are hereby released from any responsibility for, any damage either to person or
property or resulting from the loss of use thereof, which damage is sustained by Tenant or by other
persons claiming through Tenant, except to the extent caused by the negligence or willful
misconduct of Landlord or a Landlord Party (excluding any independent contractor hired by Landlord
at Tenant’s request) or by Landlord’s breach of its obligations under this Lease. Tenant shall
indemnify, defend, protect, and hold harmless the Landlord Parties from any and all loss, cost,
damage, expense and liability (including without limitation court costs and reasonable attorneys’
fees) incurred in connection with or arising from any cause in, on or about the Premises, or
arising from any acts, omissions or negligence of Tenant or of any person claiming by, through or
under Tenant, or of the contractors, agents, servants, employees, invitees, guests or licensees of
Tenant, (individually, a “Tenant Party” and collectively, “Tenant Parties”) in, on or about the
Building or any breach by Tenant of the terms, covenants, and conditions of this Lease, provided
that the terms of the foregoing indemnity shall not apply to the negligence or willful misconduct
of any Landlord Party or to Landlord’s breach of its obligations under this Lease and Tenant shall
not be liable for personal injury or property damage to any Landlord Party or its employees which
does not arise from the negligence or willful misconduct of Tenant or a Tenant Party or Tenant’s
breach

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of its obligations under this Lease. Should Landlord be named as a defendant in any suit
brought against Tenant in connection with or arising out of Tenant’s occupancy of the Premises,
Tenant shall defend Landlord, at Tenant’s expense, with counsel selected by Tenant but subject to
Landlord’s reasonable approval. Tenant shall also pay to Landlord its other costs and expenses
incurred in such suit, including without limitation, its actual professional fees, such as
appraisers’, accountants’ and attorneys’ fees, reasonably approved by Tenant. Landlord shall
indemnify, defend, protect and hold harmless Tenant, its officers, directors, agents, and employees
from any and all claims, damages, expense and liability (including without limitation court costs
and reasonable attorneys fees) for personal injury or property damage arising from any cause in,
on, or about the Land, Building (excluding the Premises), and Common Areas, provided that the terms
of the foregoing indemnity shall not apply to the negligence or willful misconduct of Tenant or a
Tenant Party or Tenants breach of its obligations under this Lease. Should Tenant be named as a
defendant in any suit brought against Landlord in connection with or arising out of Landlord’s
obligations with respect to the Premises, Landlord shall defend Tenant, at Landlord’s expense, with
counsel selected by Landlord but subject to Tenant’s reasonable approval. Landlord shall also pay
to Tenant its other costs and expenses incurred in such suit, including without limitation, its
actual professional fees, such as appraisers’, accountants’ and attorneys’ fees, reasonably
approved by Landlord. The foregoing indemnity provisions are not intended and shall not relieve
any insurance carrier of its obligations under policies required to be carried by the indemnified
party pursuant to the provisions of this Lease, to the extent such policies cover the matters
subject to the Parties’ foregoing indemnification obligations; nor shall they supersede any
inconsistent agreement of the parties set forth in any other provision of this Lease. The
provisions of this Paragraph 15 shall survive the expiration or sooner termination of this Lease
with respect to any claims or liability arising in connection with any event occurring prior to
such expiration or termination. Notwithstanding anything to the contrary contained in this Lease,
nothing in this Lease shall impose any obligations on Tenant or Landlord to be responsible or
liable for, and each hereby releases the other from all liability for, consequential damages other
than those consequential damages incurred by Landlord in connection with a holdover of the Premises
by Tenant after the expiration or earlier termination of this Lease or incurred by Landlord in
connection with any repair, physical construction or improvement work performed by or on behalf of
Tenant in the Building.

16. DAMAGE TO TENANT’S PROPERTY. Notwithstanding any provisions of this Lease to the
contrary, neither Landlord nor its partners,
agents, employees, independent contractors, or property manager shall be liable for any damage to
Tenant’s property, nor for loss of or damage to any property by theft or otherwise, nor for any
injury or damage to persons or property resulting from fire, explosion, falling plaster, steam,
gas, electricity, water or rain which may leak from any part of the Premises or adjoining buildings
or from the pipes, appliances or plumbing works therein or from the roof, street or sub-surface or
from any other place or resulting from dampness or any other cause whatsoever, unless the same is
caused by the negligence or willful misconduct of the Landlord or Landlord’s breach of its
obligations under this Lease. Landlord or its agents shall not be liable for interference with the
light or other intangible properties, nor, except to the extent set forth in this Lease, shall
Landlord be liable for any loss or damage caused by latent defect in the Premises or Building or in
the adjoining properties. Tenant shall give prompt notice to Landlord in case of fire or accidents
in the Premises or of defects therein or in the fixtures or equipment.

17. INSURANCE SUBROGATION. The parties release each other, and their partners, officers,
agents, and employees from any claims for injury to any person or damage to the Premises, Common
Areas, or Building and to the fixtures, personal property, tenant improvements, and alterations of
either Landlord or Tenant in or on the Premises, Common Areas, or Building that are caused by or
result from risks insured against under any insurance policies carried by the parties and in force
at the time of any such damage or which would be covered by any insurance required to be maintained
by this Lease, provided that such release shall not include reasonable insurance deductibles. Each
party shall use their reasonable efforts to cause each insurance policy obtained by it to provide
that the insurance

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company waives all right of recovery by way of subrogation against the other
party in accordance with this paragraph.

18. INSURANCE.

     a. Liability: Tenant shall, at Tenant’s expense, obtain and keep in force during the
term of this Lease a policy of Commercial General Liability insurance written on an occurrence form
insuring Landlord, Landlord’s property manager, Landlord’s lender, and Tenant against any liability
arising out of the use, occupancy, maintenance, and repair or improvement of the Premises and
appurtenants thereto by Tenant. Such insurance shall provide a minimum of $3,000,000 combined
single limit each occurrence and $4,000,000 annual aggregate for bodily injury, personal injury and
property damage. The minimum limits of this liability policy shall be subject to increase at any
time, and from time to time, after the first full Lease Year if the Landlord shall reasonably deem
such increased coverage necessary for adequate protection or if required by Landlord’s lender. The
liability policy shall contain cross-liability and contractual liability endorsements (covering
Tenant’s indemnity obligations hereunder other than the indemnity contained in Paragraph 43 below
pertaining to Hazardous Materials). The limits of said insurance shall not, however, limit the
liability of the Tenant hereunder, and Tenant is responsible for ensuring that the amount of
liability insurance carried by Tenant is sufficient for Tenant’s purposes. Tenant may carry said
insurance under a blanket policy so long as a “per location” liability aggregate limit is
maintained, reasonably satisfactory to Landlord. If Tenant shall fail to procure and maintain said
insurance, Landlord may, but shall not be required to, procure and maintain same, but at the
expense of Tenant. Insurance required hereunder shall be in companies rated “A-X” or better in the
most current issue of “AM Best’s Insurance Guide.” Tenant shall deliver to Landlord prior to
occupancy of the Premises evidence of liability insurance required herein by a Certificate of
Insurance outlining the amounts of such insurance and naming Landlord, Landlord’s property manager,
and Landlord’s lender as additional insureds, with evidence satisfactory to Landlord of payment of
premiums. No policy shall be cancelable or subject to reduction of coverage except after thirty
(30) days’ prior written notice to Landlord.

     b. Landlord’s Insurance: Landlord shall obtain and maintain the insurance coverage
specified and required in Paragraph 3.(c)(ii) of this Lease. Tenant acknowledges and agrees that
insurance coverage carried by Landlord will not cover Tenant’s property
within the Premises or the Building and that Tenant shall be responsible, at Tenant’s sole
cost and expense, for obtaining and maintaining insurance coverage for Tenant’s equipment,
furnishings, trade fixtures and other personal property in or upon the Premises or the Building,
and for any tenant improvements installed by Tenant (including the Initial Tenant Improvements) and
any alterations, additions or improvements to or of the Premises or any part thereof made by
Tenant, in the event of damage or loss thereto from any cause whatsoever. Notwithstanding the
foregoing, Landlord may elect to maintain insurance coverage for all interior improvements in the
Premises.

     c. Tenant’s Personal Property Insurance and Worker’s Compensation Insurance: Tenant
shall obtain and maintain a policy or policies of fire and property damage insurance in “all risk”
form, with a sprinkler leakage endorsement if such coverage is not included in the “all risk”
definition, insuring the equipment, furnishings, personal property, trade fixtures, and any
leasehold improvements made by Tenant for the full replacement value thereof. The proceeds from
any of such policies with respect to leasehold improvements shall be used for the repair or
replacement of such items so insured if such lease is not terminated pursuant to the terms of
Paragraph 19 below. If this Lease is terminated pursuant to Paragraph 19, the amount of proceeds
applicable to leasehold improvements shall be paid to Landlord and Tenant may retain the balance of
the proceeds.

Tenant shall also maintain a policy or policies of worker’s compensation insurance and any other
employee benefit insurance sufficient to comply with all laws to cover all persons employed in
connection with any finish work, repair, alterations and all employees and/or agents of Tenant.

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     d. Tenant’s Insurance: (i) shall be in customary form and shall be carried with
companies that are licensed to do business in the State of California and have ratings in the most
current issue of AM Best’s Insurance Guide of not less than A-X for all coverage; (ii) shall
provide that such policies shall not be subject to cancellation or any material changes except
after at least thirty (30) days prior written notice to Landlord; and (iii) shall be primary and
insurance carried by Landlord shall be non-contributing. Tenant’s certificates of insurance,
including waiver of subrogation endorsements, shall be deposited with Landlord prior to the
Commencement Date and thirty (30) days prior to the renewal of such policies.

19. DAMAGE OR DESTRUCTION.

a. If at any time during the term of this Lease there is damage or destruction for which the
cost to repair is twenty-five percent (25%) or more of the replacement value of the Premises or of
the entire Building (a “Casualty”), Landlord shall within, thirty (30) days after Landlord’s
receipt of notice from Landlord’s insurer of its determination of the insurer’s proposed coverage
of the Casualty, provide written notice to Tenant (“Repair Notice”) stating the anticipated period
for repairing the damage and whether Landlord has elected to repair the damage or terminate this
Lease. The Repair Notice shall be accompanied by a certified statement executed by a contractor
retained by Landlord to complete the repairs, or, if Landlord has not retained a contractor, a
licensed contractor not affiliated with Landlord, certifying the contractor’s estimate of the
anticipated period for repairing the Casualty.

Landlord may elect to terminate this Lease if (i) the contractor’s estimated period for repairing
the casualty exceeds one hundred eighty (180) days from the date of Casualty, or (ii) the Casualty
is caused by a peril not required to be insured against by this Lease and is not actually insured
against, or (iii) the insurance proceeds plus deductible amount will not be sufficient to repair
the Casualty (based upon the estimated cost to repair prepared by the contractor providing the
estimate of the time period to repair). Landlord may not elect to terminate this Lease under this
Article unless Landlord also elects to terminate the leases of all similarly situated tenants,
provided that Landlord has the right under each applicable lease to terminate based on the extent
of the Casualty. Tenant may elect to terminate this
Lease if the contractor’s estimated period for repairing the casualty exceeds one hundred eighty
(180) days from the date of Casualty.

If the Repair Notice indicates that the anticipated period for repairing the Casualty exceeds one
hundred eighty (180) days from the date of Casualty, Tenant may elect to terminate this Lease by
providing written notice to Landlord within ten (10) days after Tenant’s receipt of the Repair
Notice.

If this Lease is not terminated pursuant to this Section, Landlord shall diligently commence repair
and restoration and prosecute the same to completion.

     b. Upon any termination of this Lease under any of the provisions of this Paragraph 19, the
parties shall be released thereby without further obligation to the other from the date possession
of the Premises is surrendered to the Landlord except for items which have therefore accrued and
are then unpaid.

     c. In the event of any Casualty, the rental provided to be paid under this Lease shall be
abated proportionally in the ratio which the Tenant’s use of said Premises is impaired during the
period of such repair, reconstruction or restoration. Tenant shall not be entitled to any
compensation or damages for loss in the use of the whole or any part of said Premises and/or any
inconvenience or annoyance occasioned by such damage, repair, reconstruction or restoration.

     d. Tenant shall not be released from any of its obligations under this Lease except as
expressly stated in this Paragraph 19. Notwithstanding anything to the contrary contained in this
Paragraph 19, should Landlord be delayed or prevented from repairing or restoring said damaged

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Premises within one (1) year after the occurrence of such damage or destruction by reason of acts
of God, war, governmental restrictions, inability to procure the necessary labor or materials, or
other causes beyond the reasonable control of Landlord, Landlord shall be relieved of its
obligation to make such repairs or restoration and Tenant shall be released from its obligations
under this Lease as of the end of said one (1) year period.

     e. If Landlord is obligated to or elects to repair or restore as herein provided, Landlord
shall be obligated to make repairs or restoration only of those portions of said Premises which are
Landlord’s obligations to maintain under Paragraph 11; and the repair and restoration of any
leasehold improvements made by Tenant (including the Initial Tenant Improvements) and any other
alterations or improvements made to the Premises by Tenant, and Tenant’s FF&E shall be the
obligation of Tenant.

     f. Notwithstanding anything to the contrary contained in this Paragraph, Landlord shall have
no obligation whatsoever to repair, reconstruct or restore the Premises and this Lease shall
terminate thirty (30) days after notice from Landlord (1) if the damage is due to a cause not
required to be insured against or (2) when the damage occurs during the last twelve (12) months of
the term of this Lease; provided that if Tenant then has an option to extend the then term for a
period of at least five years, Tenant has previously exercised the option to extend the term or
exercises such option with thirty (30) days after the date of Landlord’s notice referred to in this
sentence.

     g. The provisions of Section 1932 (2), and Section 1933 (4), of the California Civil Code are
hereby waived by Tenant.

20. EMINENT DOMAIN. If the whole of the Premises, or such part thereof as shall
substantially interfere with Tenant’s use and occupancy thereof, shall be taken for any public or
quasi-public purpose by any lawful power or authority, by exercise of the right of appropriation,
condemnation or eminent domain, or sold to prevent such taking, or the Premises are subject to a
temporary taking which shall exceed twelve (12) months, Tenant or Landlord, may, at its option,
terminate this Lease effective as of the date possession is required to be surrendered to said
authority. Tenant shall not, because of such taking, assert any claim against Landlord or the
taking authority for any compensation because of such taking except as specifically described
below, and Landlord shall be entitled to receive the entire amount of any award without deduction
for any estate or any interest of Tenant, except for the unamortized cost of any leasehold
improvements installed at Tenant’s sole expense. In the event the amount of property or the type
of estate taken shall not substantially interfere with the conduct of Tenant’s business, Landlord
shall be entitled to the entire amount of the award without deduction for any estate or interest of
Tenant. If Landlord does not so elect to terminate this Lease, Landlord shall promptly proceed to
restore the Premises to substantially their same condition prior to such partial taking, and a
proportionate allowance shall be made to Tenant for the rent corresponding to the time during which
said restoration is being made and to the part of the Premises of which Tenant shall be so deprived
on account of such taking and restoration. Nothing contained in this Paragraph shall be deemed to
give Landlord any interest in any specific award made to Tenant for the taking of personal property
and removable trade fixtures belonging to Tenant or for relocation of Tenant’s business. If the
Premises are subject to a temporary taking of twelve (12) months or less, Tenant shall be entitled
to any award for such temporary taking and there shall be no abatement or diminution of Base Rent
or Additional Rent due under this Lease.

21. DEFAULTS AND REMEDIES.

     a. Default by Tenant. The occurrence of any one or more of the following events shall
constitute an Event of Default hereunder by Tenant:

          (i) The abandonment or vacation of the Premises without making adequate provision for
security, whether or not Tenant is in monetary or other default of this lease. Abandonment

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is
herein defined to include, but is not limited to, any cessation of business for seven (7) days or
longer. Tenant shall be deemed to have made adequate provision for security if Tenant has given
Landlord ten (10) days of notice of intent to vacate the Premises and after such vacation Tenant
complies with a security program for vacation previously approved by Landlord.

          (ii) The failure by Tenant to make any payment of Rent or Additional Rent required to be made
by Tenant hereunder, within five (5) days after written notice thereof from Landlord to Tenant.
Such notice is in lieu of and not in addition to any notice requirements of California Code of
Civil Procedure Section 1161;

          (iii) The failure by Tenant to observe or perform any of the express or implied covenants or
provisions of this Lease to be observed or performed by Tenant, other than as specified in (i) or
(ii) above, where such failure shall continue for a period of fifteen (15) days after written
notice thereof from Landlord to Tenant, provided however, that any such notice shall be in lieu of,
and not in addition to, any notice required under California Code of Civil Procedure Section 1161;
provided, further, that if the nature of Tenant’s default is such that more than fifteen (15) days
are reasonably required for its cure, then Tenant shall not be deemed to be in default if Tenant
shall commence such cure within said fifteen (15) day period and thereafter diligently prosecute
such cure to completion, but in any event such cure shall be completed within thirty (30) days.

          (iv) To the extent permitted by law, a general assignment by Tenant or any guarantor of this
Lease for the benefit of creditors, or the taking of any corporate action in furtherance of
bankruptcy or dissolution whether or not there exists any proceeding under an insolvency or
bankruptcy law, or the filing by or against Tenant or any guarantor proceeding under an insolvency
or bankruptcy law, unless in the case of a proceeding filed against Tenant or any guarantor the
same is dismissed within sixty (60) days, or the appointment of a trustee or receiver to take
possession of all or substantially all of the assets of Tenant or any guarantor, unless possession
Is restored to Tenant or such guarantor within thirty (30) days, or any execution or other
judicially authorized seizure of all or substantially all of

          Tenant’s assets located upon the Premises or of Tenant’s interest in this Lease, unless such
seizure is discharged within thirty (30) days.

          b. Termination. In the event of an Event of Default by Tenant, in addition to any
other remedies available to Landlord at law or in equity, Landlord shall have the option to
terminate this Lease and all rights of Tenant hereunder. In the event that Landlord shall elect to
so terminate this Lease then Landlord may recover from Tenant:

          (i) The worth at the time of award of any unpaid rent which has been earned at the time of
such termination; plus

          (ii) The worth at the time of award of the amount by which the unpaid rent which would have
been earned after termination until the time of award exceeds the amount of such rental loss Tenant
proves could have been reasonably avoided; plus

          (iii) The worth at the time of award of the amount by which the unpaid rent for the balance of
the term after the time of award exceeds the amount of such rental loss Tenant proves could
reasonably be avoided; plus

          (iv) Any other amount necessary to compensate the Landlord for all the detriment proximately
caused by Tenant’s failure to perform its obligations under this Lease or which in the ordinary
course of things would be likely to result therefrom.

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As used in subparagraphs (i) and (ii) above, the “worth at the time of award” is computed by
allowing interest at the greater of (a) ten percent per annum, or (b) the prevailing discount rate
of the Federal Reserve Bank of San Francisco at the time of the award plus five (5%) percent, but
in no event greater than the maximum amount permitted under California law. As used in
subparagraph (iii) above, the “worth at the time of award” is computed by discounting such amount
at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one
percent (1%). The term “rent” as used in this Paragraph shall have the definition given in
Paragraph 3.i and includes all amounts of every nature required to be paid by Tenant pursuant to
the terms of this Lease, whether to Landlord or to other parties.

     c. Section 1951.4 Remedy. Landlord shall have the remedy described in California
Civil Code Section 1951.4 (lessor may continue lease in effect after lessee’s breach and
abandonment and recover rent as it becomes due, if lessee has the right to sublet or assign,
subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this
Lease on account of any default by Tenant, Landlord may, from time to time, without terminating
this Lease, enforce all of its rights and remedies under this Lease, including the right to recover
all rent as it becomes due.

     d. Re-entry. In the event of an Event of Default by Tenant, Landlord shall also have
the right, with or without terminating this Lease, to re-enter the Premises and remove all persons
and property from the Premises; such property may be removed and stored in a public warehouse or
elsewhere at the cost of and for the account of Tenant. No re-entry or taking possession of the
Premises by Landlord pursuant to this subparagraph shall be construed as an election to terminate
this Lease unless a written notice of such intention be given to Tenant or unless the termination
thereof be decreed by a court of competent jurisdiction.

     e. Right to Perform. If Tenant fails to perform any obligation required under this
Lease or by law or governmental regulation, Landlord in its sole discretion may, without notice,
without waiving any rights or remedies and without releasing Tenant from its obligations hereunder,
perform such obligation, in which event Tenant shall pay Landlord as Additional
Rent all out-of-pocket sums paid by Landlord in connection with such substitute performance,
including interest as provided below within ten (10) days of Landlord’s written demand for such
payment.

     f. Cumulative. Landlord shall at all times have the rights and remedies (which shall
be cumulative with each other and cumulative and in addition to those right and remedies available
under subparagraphs b, c, d, and e above, or any law or other provision of this Lease), without
prior demand or notice except as required by applicable law, to seek any declaratory, injunctive or
other equitable relief, and especially enforce this Lease, or restrain or enjoin a violation or
breach of any provision hereof.

     g. Repetitive Default. Notwithstanding any provisions to the contrary, the parties
agree that if Tenant shall have defaulted in the performance of any (but not necessarily the same)
term or condition of this Lease for three or more times during any 12-month period during the Lease
Term, then such conduct shall, at the election of the Landlord, represent a separate event of
default which cannot be cured by Tenant. Tenant acknowledges that the purpose of this provision is
to prevent repetitive defaults by Tenant, which work a hardship upon Landlord and deprive Landlord
of Tenant’s timely performance under the Lease.

     h. Landlord Default. In the event Landlord fails or refuses to perform any of the
provisions, covenants or conditions of this Lease on Landlord’s part to be kept or performed,
Tenant, prior to exercising any other right or remedy Tenant may have against Landlord on account
of any such default, shall provide fifteen (15) days written notice to Landlord of such default,
specifying in reasonable detail the alleged nature of the default and specifically referencing each
paragraph and subparagraph which Tenant believes to be in default. Notwithstanding any other
provision hereof, Tenant agrees that if said

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default is of such a nature that the same can be
rectified or cured by Landlord but cannot with reasonable diligence be rectified or cured within
said thirty (30) day period, then Landlord shall not be in default if Landlord within said thirty
(30) day period shall have diligently commenced the rectification or curing thereof and shall
diligently continue thereafter to cause such rectification or curing to proceed to completion. In
addition, upon any such failure by Landlord, Tenant shall give notice by registered or certified
mail to any person or entity with a security interest in the Premises (“Mortgagee”) (which notice
may be given concurrently with notice to Landlord) that has provided Tenant with notice of its
interest in the Premises, and shall provide Mortgagee a reasonable opportunity to cure such
failure. Tenant agrees that each of the Mortgagees to whom this Lease has been assigned is an
express third-party beneficiary of this Paragraph 12.h. Tenant waives any right under California
Civil Code Section 1950.7 or any other present or future law to the collection of any payment or
deposit from Mortgagee or any purchaser at a foreclosure sale of Mortgagee’s interest unless
Mortgagee or such purchaser shall have actually received and not refunded the applicable payment or
deposit.

Failure by Landlord to perform any defined services, or any cessation thereof, when such failure is
caused by Force Majeure shall not render Landlord liable to Tenant in any respect, including
damages to either person or property, nor be construed as an eviction of Tenant, nor cause an
abatement of rent, nor relieve Tenant from fulfillment of any covenant or agreement hereof. Should
any equipment or machinery utilized in supplying the services listed herein break down or for any
cause cease to function properly, upon receipt of written notice from Tenant of any deficiency or
failure of any services, Landlord shall use reasonable diligence to repair the same promptly, but
Tenant shall have no right to terminate this Lease and shall have no claim for rebate of rent or
damages on account of any interruptions in service occasioned by Force Majeure or resulting
therefrom.

In consideration of the benefits accruing hereunder, Tenant and all successors and assigns covenant
and agree that, in the event of any actual or alleged failure, breach or default hereunder by
Landlord, the sole and exclusive remedy against Landlord shall be satisfied only out of Landlord’s
equity in the
Building and no other real or personal property of Landlord or its partners shall be subject to
levy on any judgment obtained against Landlord.

22. ASSIGNMENT AND SUBLETTING.

     A. Consent by Landlord: Except as specifically provided in this Paragraph 22, Tenant
may not assign, sublet, hypothecate, or allow a third party to use or occupy the Premises without
the express written consent of Landlord, which consent shall not be unreasonably withheld or
delayed. In the event Tenant desires to assign this Lease or any interest herein including,
without limitation, a pledge, mortgage or other hypothecation, or sublet the Premises or any part
thereof, Tenant shall deliver to Landlord (i) executed counterparts of any agreement and of all
ancillary agreements with the proposed assignee/subtenant, (ii) current financial statements of the
transferee covering the current and preceding three years, (iii) the nature of the proposed
transferee’s business to be carried on in the Premises, and (iv) a statement of all consideration
to be given on account of the transfer. Landlord may condition its approval of any transfer to a
certification from both Tenant and the proposed transferee of all consideration to be paid to
Tenant in connection with such transfer. At Landlord’s request, Tenant shall also provide
additional information reasonably required by Landlord to determine whether it will consent to the
proposed assignment or sublease. Landlord shall have a fifteen (15) day period following receipt
of all the foregoing within which to notify Tenant in writing that Landlord elects to: (i) permit
Tenant to assign or sublet such space to the named assignee/subtenant on the terms and conditions
set forth in the notice; or (ii) refuse consent. If Landlord should fail to notify Tenant in
writing of such election within the fifteen (15) day period, Landlord shall be deemed to have
elected option (ii) above. Landlord’s written consent to the proposed assignment or sublease shall
not be unreasonably withheld. If any or any one of the following circumstances exist, Landlord
shall be deemed to have acted reasonably if it denies consent: (i) the proposed assignee or
subtenant is engaged in a business that is not within the use expressly permitted under this Lease
or violates any exclusivity provision of

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another lease in the Building; (ii) the proposed assignee
or subtenant is a tenant in the building or an affiliate of such tenant or a party that Landlord or
Landlord’s broker has entered into discussions with as a prospective tenant in the Building within
ninety (90) days of Tenant’s proposal; (iii) Landlord has reasonably equivalent space available for
rent in the Building, (iv) the proposed assignee or subtenant is not a company with sufficient
financial worth and management ability to undertake the financial obligation of this Lease or
Landlord has not been furnished with reasonable proof thereof; (v) the proposed assignment or
sublease is not in form reasonably satisfactory to Landlord; (vi) the amount of the aggregate rent
to be paid by the proposed subtenant is less than the then current fair market value (based upon
factors used in determining Fair Market Rental in Paragraph 46 which are applicable to the sublease
and other applicable factors) ; (vii) Tenant does not reimburse Landlord on demand for all
reasonable costs that may be incurred by Landlord in connection with said assignment or sublease,
including the costs of making investigations as to the acceptability of the proposed assignee or
subtenant and legal costs incurred in connection with the granting of any requested consent; and
(viii) Tenant has publicly advertised or publicized the availability of the Premises without prior
notice to Landlord.

     B. Assignment or Subletting Consideration: One hundred percent (100%) of any Rent or
other economic consideration realized by Tenant for any sublease or assignment of Tenant’s
leasehold interest in excess of the Rent payable hereunder for the portion of the Premises
subleased or assigned and after recovery by Tenant of Tenant’s reasonable subletting and assignment
costs (such as tenant improvements for the proposed subtenant, real estate commissions, and legal
fees) shall be paid to Landlord as Additional Rent. The above provision relating to Landlord’s
right to a portion of the bonus rent is an independently negotiated term of this Lease which
constitutes a material inducement for the Landlord to enter into the Lease, and is agreed by the
parties to be commercially reasonable. No assignment or subletting by Tenant shall relieve it of
any obligation under this Lease. Any assignment or subletting which conflicts with the provisions
hereof shall be void.

     C. No Release: Any assignment or sublease, including a Permitted Transfer, shall be
made only if and shall not be effective until the assignee or subtenant shall execute, acknowledge,
and deliver to Landlord an agreement, in form and substance satisfactory to Landlord, whereby the
assignee or subtenant shall assume all the obligations of this Lease (in the case of a sublease,
those obligations applicable to a subtenant) on the part of Tenant to be performed or observed and
shall be subject to all the covenants, agreements, terms, provisions and conditions in this Lease.
Notwithstanding any such sublease or assignment and the acceptance of rent by Landlord from any
subtenant or assignee, Tenant and any guarantor shall remain fully liable as a primary obligor for
the payment of Base Rent and Additional Rent due, and to become due hereunder, for the performance
of all the covenants, agreements, terms, provisions and conditions contained in this Lease on the
part of Tenant to be performed and for all acts and omissions of any licensee, subtenant, assignee
or any other person claiming under or through any subtenant or assignee that shall be in violation
of any of the terms and conditions of this Lease, and any such violation shall be deemed a
violation by Tenant. Tenant shall indemnify, defend and hold Landlord harmless from and against
all losses, liabilities, damages, costs and expenses (including reasonable attorney fees) resulting
from any claims that may be made against Landlord by the proposed assignee or subtenant, or by any
real estate brokers or other persons claiming compensation in connection with the proposed
assignment or sublease.

     D. Reorganization of Tenant: If Tenant is a corporation or limited liability company,
the following shall be deemed an assignment of Tenant’s interest in this Lease governed by the
provisions of this Paragraph 22: (i) any dissolution, merger, consolidation, conversion, or other
reorganization of or affecting Tenant, whether or not Tenant is the surviving entity, or (ii) the
sale or transfer to one person or entity (or to any group of related persons or entities) of stock
or membership interests possessing more than 50% of the total combined voting power of all classes
of Tenant’s capital stock or membership interests entitled to vote on issues requiring vote of
members or stockholders. The sale of

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Tenant’s capital stock through any public exchange or
issuance for the purpose of raising financing shall not be deemed an assignment of this Lease.

     E. Permitted Transfers: Notwithstanding anything contained in this Paragraph 22, so
long as Tenant otherwise complies with the provisions of this Article, Tenant may enter into any of
the following transfers (a “Permitted Transfer”) without Landlord’s prior consent, and Landlord
shall not be entitled to terminate the Lease or to receive any part of any sub-rent resulting
therefrom that would otherwise be due pursuant to this paragraph. Tenant may sublease all or part
of the Premises or assign its interest in this Lease to (i) any corporation, limited liability
company, or other entity which controls, is controlled by, or is under common control with the
original Tenant to this Lease by means of an ownership interest of more than 50%; provided,
however, that if this Lease is assigned to an entity under common control with Tenant (e.g., from
Tenant to another subsidiary or other entity controlled by the entity with a controlling interest
in Tenant), Landlord shall have the right to require that the controlling entity guarantee this
Lease by guaranty in form and substance acceptable to Landlord as a condition to such assignment
being a Permitted Transfer, (ii) a successor corporation, limited liability company, or other
entity, which results from a merger, consolidation or other nonbankruptcy reorganization in which
Tenant is not the surviving entity, so long as the successor has a net worth at the time as such
assignment that is equal to or greater than the net worth of Tenant immediately prior to such
transaction; and (iii) an entity which purchases or otherwise acquires all or substantially all of
the assets of Tenant so long as such acquiring entity has a net worth at the time of such
assignment that is equal to or greater than the net worth of Tenant immediately prior to such
transaction.

     G. Effect of Default: Tenant hereby assigns all Rents due from any assignment or
subletting to Landlord as security for performance of its obligations under this Lease, and in the
event of an Event of Default, Landlord may collect such rents as Tenant’s Attorney-in-Fact, except
that Tenant may collect such rent so long as no Event of Default has occurred
and is continuing. A Lease termination due to Tenant’s default shall not automatically
terminate an assignment or sublease then in existence; rather at Landlord’s election, such
assignment or sublease shall survive the Lease termination, the assignee or subtenant shall attorn
to Landlord, and Landlord shall undertake the obligations of Tenant under the sublease or
assignment; except that Landlord shall not be liable for prepaid rent, security deposits or other
defaults of Tenant to the subtenant or assignee, or for any acts or omissions of Tenant and
Tenant’s Agents.

     H. Successors and Assigns: Subject to the provisions in this Paragraph 22, the
covenants and conditions of this Lease shall apply to and bind the successors and assigns of the
parties hereto.

23. PEACEFUL USE. So long as Tenant shall perform each and every term, condition and
covenant to be performed by Tenant hereunder, Tenant shall have the absolute right to exclusive
occupancy of the Premises without interference or hindrance on the part of Landlord until the
termination of this Lease and the end of the Lease term herein, including any option period, and
Landlord shall warrant and defend Tenant in such peaceful use and possession under Landlord.
Tenant’s rights under this Lease shall be provided by Landlord to any lender, ground lessor or any
other individual or entity claiming a security interest on the Premises now or hereafter placed
relating to the Building or any part or parts thereof by the Landlord as an affirmative obligation
of Landlord.

24. SUBORDINATION. This Lease is subject and subordinate to ground and underlying leases,
mortgages and deeds of trust (collectively “Encumbrances”) which may now affect the Premises, to
any covenants, conditions or restrictions of record, and to all renewals, modifications,
consolidations, replacements and extensions thereof; provided, however, if the holder or holders of
any such Encumbrance (“Holder”) require that this Lease be prior and superior thereto, within seven
(7) days after written request of Landlord to Tenant, Tenant shall execute, have acknowledged and
deliver all documents or instruments, in commercially reasonable form, which Landlord or Holder
deems necessary or desirable for such purposes. This Lease shall be and become and remain subject
and

xxii

 

subordinate to any and all Encumbrances which may hereafter be executed covering the Premises
or any renewals, modifications, consolidations, replacements or extensions thereof, for the full
amount of all advances made or to be made thereunder and without regard to the time or character of
such advances, together with interest thereon and subject to all the terms and provisions thereof;
provided only, that in the event of termination of any such lease or upon the foreclosure of any
such mortgage or deed of trust or transfer in lieu thereof, the applicable Holder agrees in writing
to recognize Tenant’s rights under this Lease, including the option to extend, as long as no Event
of Default by Tenant exists and Tenant continues to pay Base Monthly Rent and Additional Rent and
observes and performs all required provisions of this Lease. Within seven (7) days after
Landlord’s written request, Tenant shall execute any documents required by Landlord or the Holder
to make this Lease subordinate to any lien of the Encumbrance, provided that the applicable Holder
agrees in writing to recognize Tenant’s rights under this Lease as long as Tenant is not then in
default and continues to pay Base Monthly Rent and Additional Rent and observes and performs all
required provisions of this Lease and such document does not increase Tenant’s costs or expenses
under this Lease or materially and adversely affect Tenant’s rights or obligations under this
Lease. Tenant agrees that the form of subordination, nondisturbance, and attornment agreement
attached hereto as Exhibit “E” satisfies the requirement of the preceding sentence. If Tenant
fails to do so, then in addition to such failure constituting a default by Tenant, it shall be
deemed that this Lease is so subordinated to such Encumbrance. Notwithstanding anything to the
contrary in this Section, Tenant hereby attorns and agrees to attorn to any entity purchasing or
otherwise acquiring the Premises at any sale or other proceeding or pursuant to the exercise of any
other rights, powers or remedies under such encumbrance, provided that in the event of termination
of any such ground lease or upon the foreclosure of any such mortgage or deed of trust or transfer
in lieu thereof, the applicable Holder recognizes Tenant’s rights under this Lease as long as no
Event of Default exists by Tenant and
Tenant continues to pay Base Monthly Rent and Additional Rent and observes and performs all
required provisions of this Lease. Landlord agrees to use commercially reasonable efforts to
deliver to Tenant within sixty (60) days after the date of execution of this lease a subordination,
nondisturbance and attornment agreement between Tenant and Landlord’s lender in the form of Exhibit
“E” attached hereto.

25. ESTOPPEL CERTIFICATE. Tenant shall, at any time and from time to time upon not less
than ten (10) business days’ prior written notice from Landlord, execute, acknowledge and deliver
to Landlord a statement in writing (i) certifying that this Lease is unmodified and in full force
and effect (or, if modified, stating the nature of such modification and certifying that this Lease
as so modified, is in full force and effect) and the dates to which the rental and other charges
are paid in advance, if any, and (ii) acknowledge that there is not, to Tenant’s knowledge, any
uncured defaults on the part of the Landlord hereunder, or specifying such defaults, if any, that
are claimed, and (iii) certifying such other items as the lender or purchaser may reasonably
request. Any such statement may be relied upon by a prospective purchaser or lender of all or any
portion of the real property of which the Premises are a part.

Tenant’s failure to deliver such statement within such time shall be conclusive upon Tenant (i)
that this Lease is in full force and effect, without modification except as may be represented by
Landlord, (ii) that there are no uncured defaults in Landlord’s performance, and (iii) that not
more than one month’s rental has been paid in advance. Tenant agrees to provide, within ten (10)
business days of Landlord’s request, Tenant’s most recent three (3) years of audited financial
statements or Federal tax returns for Landlord’s use in financing the Premises or Landlord’s
interest therein so long as the party receiving such financial information agrees in writing to
maintain the information in confidence.

26. CHOICE OF LAW AND VENUE. This Lease shall be governed by and construed pursuant to the
laws of the State of California and the parties agree that venue shall be in Santa Clara County.

27. SUCCESSORS AND ASSIGNS. This Lease shall be binding upon and shall inure to the
benefit of the parties hereto and their respective heirs, personal representatives, successors and
assigns.

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28. SURRENDER OF LEASE. The voluntary or other surrender of this Lease by Tenant, or a
mutual cancellation thereof, shall not automatically effect a merger of the Lease with Landlord’s
ownership of the Premises. Instead, at the option of Landlord, Tenant’s surrender may terminate
all or any existing subleases or subtenancies or may operate as an assignment to Landlord of any or
all such subleases or subtenancies, thereby creating a direct Landlord-tenant relationship between
Landlord and any subtenants.

29. ATTORNEYS’ FEES. In the event that either party should bring suit or commence
arbitration under this Lease or because of the breach of any provision of this Lease, then all
costs and expenses, including reasonable attorneys’ fees and expert fees, incurred by the
prevailing party relating to such legal action shall be paid by the other party, which obligation
on the part of the other party shall be deemed to have accrued on the date of the commencement of
such action and shall be enforceable whether or not the action is prosecuted to judgment.

30. PERFORMANCE BY TENANT. All covenants and agreements to be performed by Tenant under
any of the terms of this Lease shall be performed by Tenant at Tenant’s sole cost and expense and
without any abatement of rent. If Tenant shall fail to pay any sum of money, other than rent
required to be paid by it hereunder or shall fail to perform any other act on its part to be
performed hereunder, and such failure shall continue for thirty (30) days after notice thereof by
Landlord, Landlord may, without waiving or releasing Tenant from any
obligations of Tenant, but shall not be obligated to, make any such payment or perform any other
such action on Tenant’s part to be made or performed as in this Lease provided.

31. DEFINITION OF LANDLORD. The term “Landlord” as used in this Lease, so far as covenants
or obligations on the part of Landlord are concerned, shall be limited to mean and include only the
owner or owners at the time in question of the fee of the Building, and in the event of any
transfer, assignment or other conveyance of any such title, the Landlord herein named (and in the
case of any subsequent transfers or conveyances, the then grantor) shall be automatically freed and
relieved from and after the date of such transfer, assignment or conveyance of all liability in
respect to the performance of any covenants or obligations on the part of Landlord contained in
this Lease to be performed after the date of such transfer, assignment, or conveyance, and without
further agreement, the transferee of such title shall be deemed to have assumed agreed to observe
and perform any and all obligations of the Landlord hereunder, during its ownership of the
Premises. Landlord may transfer its interest in the Premises without the consent of Tenant and
such transfer or subsequent transfer shall not be deemed a violation on Landlord’s part of any of
the terms and conditions of this Lease.

32. WAIVER. The waiver by either party of any breach of any term, covenant, or condition
herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any
other term, covenant or condition herein contained nor shall any custom or practice which may arise
between the parties in the administration of the terms hereof be deemed a waiver of, or in any way
affect, the right of Landlord to insist upon the performance by Tenant in strict accordance with
said terms. The subsequent acceptance of rent hereunder by Landlord shall not be deemed to be a
waiver of any preceding breach by Tenant of any term, covenant or condition of this Lease, other
than the failure of Tenant to pay the particular rent so accepted, regardless of Landlord’s
knowledge of such preceding breach at the time of acceptance of such rent.

33. TERMS AND HEADINGS. The words “Landlord” and “Tenant” as used herein shall include the
plural as well as the singular. Words used in any gender include other genders. If there be more
than one Tenant the obligations hereunder imposed upon Tenant shall be joint and several. The
paragraph headings of this Lease are not a part of this Lease and shall have no effect upon the
construction or interpretation of any part thereof.

xxiv

 

34. EXAMINATION OF LEASE/NO PRESUMPTIONS AGAINST DRAFTER. Tenant understands, agrees and
acknowledges that this Lease has been freely negotiated by both parties; and that in any
controversy, dispute, or contest over the meaning, interpretation, validity, or enforceability of
this Lease or any of its terms or conditions, there shall be no inference, presumption, or
conclusion drawn whatsoever against either party by virtue of that party having drafted this Lease
or any portion thereof. Submission of this instrument for examination or signature by Tenant does
not constitute a reservation of or option for a lease, and it is not effective as a lease or
otherwise until execution by and delivery to both Landlord and Tenant.

35. TIME. Time is of the essence with respect to the performance of every provision of
this Lease in which time or performance is a factor.

36. ENTIRE AGREEMENT. This Lease contains all of the agreements of the parties hereto with
respect to any matter covered or mentioned in this Lease, and no prior agreement or understanding
pertaining to any such matter shall be effective for any purpose. Tenant does not rely on the
fact, nor does Landlord represent, that there will be any particular number of tenants or any
specific tenancy or occupant(s) of space in the Building. No provision of this Lease may be
amended or added to except by an agreement in writing signed by the parties hereto or their
respective successors in interest. Tenant acknowledges that neither Landlord nor any of its
employees or agents have made any
agreements, representations, warranties or promises with respect to the Premises or with respect to
present or future rents, expenses, operations, tenancies or any other matter except as expressly
set forth in this Lease. Except as herein expressly set forth herein, Tenant relied on no
statement of Landlord or its employees or agents for that purpose.

37. SEVERABILITY. Any provision of this Lease which shall prove to be invalid, void or
illegal in no way affects, impairs or invalidates any other provision hereof, and such other
provisions shall remain in full force and effect.

38. RECORDING. Neither Landlord nor Tenant shall record this Lease or a short form
memorandum thereof without the consent of the other.

39. EXHIBITS. All Exhibits that are referred to in this Lease and attached hereto are
incorporated herein by this reference and made a part of the Lease.

40. FORCE MAJEURE. Any prevention, delay or stoppage due to strikes, lockouts, labor
disputes, acts of God, inability to obtain services, labor, or materials or reasonable substitutes
therefore, governmental actions, inability to obtain permits, civil commotions, fire or other
casualty, and other cause beyond the reasonable control of the party obligated to perform, except
with respect to the obligations imposed with regard to Rent and other charges to be paid by Tenant
pursuant to this Lease (collectively, a “Force Majeure”), notwithstanding anything to the contrary
contained in this Lease, shall excuse the performance of such party for a period equal to any such
prevention, delay or stoppage and, therefore, of this Lease specifies a time period for performance
of an obligation of either party, that time period shall be extended by the period of any delay in
such party’s performance caused by Force Majeure.

41. SIGNS. No sign, placard, banner, picture, advertisement, name or notice (collectively,
“sign”) shall be inscribed, displayed or printed or affixed on or to any part of the outside of the
Premises or to any exterior windows of the Premises or within the lobby, elevators or any part of
Common Area without the written consent of Landlord first had and obtained. Landlord shall have
the right to remove any such sign, without notice to and at the expense of Tenant. Landlord agrees
that Tenant’s name shall be displayed in the main lobby directory, the first floor elevator lobby
and in the directories, if any, in lobby A and lobby B of the parking garage and on the third floor
in a manner comparable to that of

xxv

 

the other tenants of the Building, and Landlord shall install
identification signage adjacent to the front door of the Premises. Tenant shall be responsible for
the cost of all such signage.

Tenant shall not place anything or allow anything to be placed near the glass of any window, door
partition or wall which may appear unsightly from outside the Premises.

42. AUTHORITY. If Tenant is a corporation, then Tenant represents and warranties that it
is duly formed and in good standing, and that the Party executing this Lease is duly authorized to
execute and deliver this Lease on behalf of said corporation, in accordance with a duly adopted
resolution of the Board of Directors of said corporation or in accordance with the by-laws of said
corporation, and that this Lease is binding upon said corporation in accordance with its terms.
Unless this Lease is executed by (i) the Chairman of the Board, the President, or a Vice-president
of Tenant, and (ii) the secretary, any assistant secretary, the chief financial officer, or any
assistant treasurer of Tenant, within thirty (30) days after the execution of this Lease, Tenant
shall provide Landlord with corporate resolutions or other proof in a form acceptable to Landlord
authorizing the execution of this Lease.

43. HAZARDOUS MATERIALS.

     A. Tenant’s Responsibility: Except for Tenant’s use of ordinary general office and
janitorial supplies (such as copier and printer toner, liquid paper, glue, cleaners), Tenant shall
not bring, use, or permit upon the Premises or Building, or generate, create, release, emit, or
dispose (nor permit any of the same) from the Premises or Building any Hazardous Materials (defined
in Paragraph 43 G below) without the prior written consent of Landlord. In order to obtain
consent, Tenant shall deliver to Landlord its written proposal describing the Hazardous Material to
be brought onto the Premises or Building, measures to be taken for storage and disposal thereof,
safety measures to be employed to prevent pollution of the air, ground, surface and ground water.
Landlord’s approval may be withheld in its reasonable judgment. In the event Landlord consents to
Tenant’s use of Hazardous Materials on the Premises or Building. Tenant represents and warrants
that it will do the following: (i) adhere to all reporting and inspection requirements imposed by
federal, state, county or municipal laws, ordinances or regulations and will provide Landlord a
copy of any such reports or agency inspections; (ii) obtain and provide Landlord copies of all
necessary permits required for the use and handling of Hazardous Materials on the Premises or
Building; (iii) enforce Hazardous Materials handling and disposal practices consistent with
industry standards; and (iv) surrender the Premises or Building free from any Hazardous Materials
arising from Tenant’s bringing, using, permitting, generating, creating, releasing, emitting or
disposing of Hazardous Materials; and (v) properly close the facility with regard to Hazardous
Materials including the removal or decontamination of any process piping, mechanical ducting,
storage tanks, containers, or trenches which have come into contact with Hazardous Materials and
obtain a closure certificate from the local administering agency prior to the Expiration Date.

     B. Indemnity Regarding Hazardous Materials: Landlord and Tenant shall, at such party’s
sole cost, indemnify and hold the other harmless from, any claims, liabilities, costs or expenses
incurred or suffered by the indemnitee arising from the transporting, using, releasing, generating
or emitting or disposing of Hazardous Materials by the indemnitor or its agents or employees to,
at, or from the Premises, Land or Building during the Lease Term. The foregoing indemnification
and hold harmless obligations include, without limitation, the following: (i) claims, liability,
costs or expenses resulting from or based upon administrative, judicial (civil or criminal) or
other action, legal or equitable, brought by any private or public person under common law or under
Environmental Laws or any other federal, state, county or municipal law, ordinance or regulation;
(ii) claims, liabilities, costs or expenses pertaining to the identification, monitoring, cleanup,
containment, or removal of Hazardous Materials from soils, riverbeds or aquifers including the
provision of an alternative pubic drinking water source; and (iii) all costs of defending such
claims, the indemnifications provided above shall survive expiration or termination of this Lease
for a period of three years and shall apply to any claim made in writing

xxvi

 

during such three (3) year
period (provided that if this Lease is terminated for default of Tenant, Tenant shall have no
rights to claim the benefit of the indemnification after termination). .

     C. Actual Release by Tenant: Tenant agrees to notify Landlord of any lawsuits or
others which relate to the remedying of or actual release of Hazardous Materials on or into the
soils or ground water at or under the Premises. Tenant shall also provide Landlord all notices
required by Section 25359.7(b) of the Health and Safety Code and all other notices required by law
to be given to Landlord in connection with Hazardous Materials. Without limiting the foregoing,
Tenant shall also deliver to Landlord, within twenty (20) days after receipt thereof, any written
notices from any governmental agency alleging a material violation of, or material failure to
comply with, any federal, state or local laws, regulations ordinances or others, the violation of
which or failure to comply with poses a foreseeable and material risk of contamination of the
ground water or injury to humans (other than injury solely to Tenant, its agents and employees
within the Premises, Land or Building).

In the event of any release on or into the Premises, Land or Building or into the soil or ground
water under the Land of any Hazardous Materials used, treated, stored or disposed of by Tenant,
Tenant
agrees to comply, at its sole cost, with all laws, regulations, ordinances and orders of any
federal, sate or local agency relating to the monitoring or remediation of such Hazardous
Materials. In the event of any such release of Hazardous Materials, Tenant agrees to meet and
confer with Landlord and its Lender to attempt to eliminate and mitigate any financial exposure to
such Lender and resultant exposure to Landlord under California Code of Civil Procedure Section
736(b) as a result of such release, and promptly to take reasonable monitoring, cleanup and
remedial steps given, inter alia, the historical uses to which the Property has and continues to be
used, the risks to public health posed by the release, the then available technology and the costs
of remediation, cleanup and monitoring, consistent with acceptable customary practices for the type
and severity of such contamination and all applicable laws. Nothing in the preceding sentence
shall eliminate, modify or reduce the obligation of Tenant under of this Lease to indemnify and
hold Landlord harmless from any claims, liabilities, costs or expenses incurred or suffered by
Landlord. Tenant shall provide Landlord prompt written notice of Tenant’s monitoring, cleanup and
remedial steps.

In the absence of an order of any federal, state or local government or quasi-government agency
relating to the cleanup, remediation or other response action required by applicable law, any
dispute arising between Landlord and Tenant concerning Tenant’s obligation to Landlord under this
Paragraph concerning the level, method, and manner of cleanup, remediation or response action
required in connection with such a release of Hazardous Materials shall be resolved by dispute
resolution as set forth below.

     D. Environmental Monitoring: Landlord and its agents shall have the right to inspect,
investigate, sample and monitor the Premises including any air, soil, water, ground water or other
sampling or any other testing, digging, drilling or analysis to determine whether Tenant is
complying with the terms of this paragraph. If Landlord discovers that Tenant is not in compliance
with the terms of this paragraph, any such costs incurred by Landlord, including attorneys’ and
consultants’ fees, shall be due and payable by Tenant to Landlord within five (5) days following
Landlord’s written demand therefor.

     E. Warranties: Landlord warrants and represents to Tenant that:

          (i) to Landlord’s actual knowledge, without independent investigation or inquiry, other than a
review of the Phase I Environmental Site Assessment prepared for Principal Real Estate Investors,
LLC by Stellar Environmental Solutions and dated as of March 26, 2004, and without additional duty
of independent investigation or inquiry, as of the effective date of the Lease:

xxvii

 

          1. There has been no release, leak, discharge, spill, disposal, or emission onto
or under the Land or the Building of any Hazardous Material in violation of any
Environmental Law; and

          2. The Building contains no PCBs, PCB-contaminated electrical equipment, or
asbestos-containing materials.

          (ii) Landlord has received no notice that the Premises or the Building is in violation of any
Environmental Law.

If, during the Lease term (including any extensions), either Landlord or Tenant becomes aware of
(a) any actual or threatened release of any Hazardous Materials on, under, or about the Premises or
the Building or (b) any inquiry, investigation, proceeding, or claim by any government agency or
other person regarding the presence of Hazardous Materials on, under, or about the Premises or the
Building, that party shall give the other party written notice of the release or investigation
within five (5) days after learning of it and shall simultaneously furnish to the other party
copies of any claims, notices
of violation, reports, or other writings received by the party providing notice that concern the
release or investigation.

     F. Remediation Obligations; Tenant’s Rights on Cleanup by Landlord: If the presence
of any Hazardous Materials brought onto the Premises, Land or Building by either Landlord or Tenant
or by Landlord’s or Tenant’s employees, agents, contractors, or invitees results in contamination
of the Premises, Land or Building or poses a realistic threat of liability, that party shall
promptly take all necessary actions, at the party’s sole expense, to return the Premises, Land and
Building to the condition that existed before the introduction of such Hazardous Materials. Tenant
shall first obtain Landlord’s approval of the proposed remedial action, which may not be
unreasonably withheld or delayed. This provision does not limit the indemnification obligations
set forth above. The costs of any Hazardous Materials cleanup or remediation undertaken by
Landlord during the Lease Term for Hazardous Materials originating from any cause other than the
activities of Tenant or its agents, employees, contractors, or invitees shall be borne by Landlord
and shall not be included in Operating Expenses.

     G. Definition of Hazardous Materials: As used herein “Hazardous Materials” means any
substance which is toxic, ignitable, reactive, or corrosive or which is regulated by “Environmental
Laws”. The term “Environmental Laws” means federal, state and local laws and regulations,
judgments, orders and permits governing safety and health and the protection of the environment,
including without limitation the Comprehensive Environmental Response, Compensation and Liability
Act 42, U.S.C. 9601 et seq., as amended CERCLA), the Resource Conservation and Recovery Act, as
amended 42 U.S.C. U.S.C. 6901 et seq., the Clean Water Act, 33 U.S.C. 1251 et seq., the Clean Air
Act, 42 U.S. C. 7401 et seq., the Toxic Substance Control Act, 15 U.S.C. 2601 et seq., and the Safe
Drinking Water Act, U.S.C. 300f through 300j, and Division 22 Title 26 of the California Code of
Regulation, all of which may be amended from time to time. “Hazardous Materials” includes any and
all materials or substances which are defined as “hazardous waste”, “extremely hazardous waste” or
a “hazardous substance” pursuant to state, federal or local governmental law. “Hazardous
Substances” also includes asbestos, polychlorinated biphenyls (“PCBs” and petroleum products).

44. DISPUTE RESOLUTION. Landlord and Tenant and any other party that may become a party to
this Lease or be deemed a party to this Lease including any subtenants agree to and shall mediate
any controversy, dispute, or claim of whatever nature arising out of, in connection with, or in
relation to the interpretation, performance or breach of this Lease, including any claim based on
contract, tort, or statute, except for any claim by Landlord for unlawful detainer, or any action
within the jurisdiction of the small claims court. The mediation shall be held prior to any court
action or arbitration. The mediation shall be confidential and in accordance with California
Evidence Code Section 1152.5. In the event the

xxviii

 

parties are not able to agree on a mediator within
thirty days, JAMS or another judicial and mediation service mutually acceptable to the parties
shall appoint a mediator. In the event the mediator determines that a second mediation session is
necessary, it shall be conducted in accordance with this paragraph. SHOULD THE PREVAILING PARTY
ATTEMPT AN ARBITRATION OR A COURT ACTION BEFORE ATTEMPTING TO MEDIATE, THE PREVAILING PARTY SHALL
NOT BE ENTITLED TO ATTORNEYS FEES THAT MIGHT OTHERWISE BE AVAILABLE TO THEM IN A COURT ACTION OR
ARBITRATION, AND IN ADDITION THERETO, THE PARTY WHO IS DETERMINED BY THE ARBITRATOR TO HAVE
RESISTED MEDIATION SHALL BE SANCTIONED BY THE ARBITRATOR OR JUDGE. Except for any claim by
Landlord for unlawful detainer or any claim within the jurisdiction of the small claims court
(which for such claims the parties agree shall be the sole court of competent jurisdiction), any
controversy, dispute, or claim of whatever nature arising out of, in connection with, or in
relation to the interpretation, performance or breach of this Lease, including any claim based on
contract, tort, or statute, shall be resolved at the request of any party to this agreement through
a mediation process as provided above administered by JAMS or another judicial and mediation
service mutually acceptable to
the parties, followed, if necessary, by final and binding arbitration administered by and in
accordance with the then-existing rules and practice of the judicial and mediation service
selected, and judgment upon any award rendered by the arbitrator(s) may be entered by any State or
Federal Court having jurisdiction thereof. The parties to the arbitration shall have those rights
of discovery that the arbitrator(s) deem necessary (after application to the arbitrator(s)) to a
full and fair hearing of the matter. However, in no event shall the parties be entitled to
propound interrogatories or requests for admissions during the arbitration process. The arbitrator
shall be a retired judge or a licensed California Attorney. The venue for any such arbitration’s
or mediations shall be in Santa Clara County. The Arbitrator shall award to the prevailing party
its out-of-pocket costs (and only out-of-pocket costs) for attorney’s fee and costs.

45. INTEREST. All Rent, Additional Rent and all other charges due from Tenant to Landlord,
if not paid when due, shall bear interest at the lesser of (1) the twelve percent (12%) or (2) the
maximum rate permitted by law (“Agreed Interest Rate”). This provision shall survive the
expiration or sooner termination of the Lease. Despite any other provision of this Lease, the
total liability for interest payments shall not exceed the limits, if any, imposed by the usury
laws of the State of California. Any interest paid in excess of those limits shall be refunded to
Tenant by application of the amount of excess interest paid against any sums outstanding in any
order that Landlord requires. If the amount of excess interest paid exceeds the sums outstanding,
the portion exceeding those sums shall be refunded in cash to Tenant by Landlord. To ascertain
whether any interest payable exceeds the limits imposed, any non-principal payment(including late
charges) shall be considered to the extent permitted by law to be an expense or a fee, premium, or
penalty rather than interest.

46. MODIFICATIONS REQUIRED BY LENDER. If any Lender of Landlord or ground lessor of the
Real Property requires a modification of this Lease that will not increase Tenant’s cost or expense
or materially or adversely change Tenant’s rights and obligations, this Lease shall be so modified
and Tenant shall execute whatever documents are reasonably required and deliver them to Landlord
within thirty (30) days after the request.

47. PARKING. Tenant shall have the non-exclusive right to use, in common with other tenants
or occupants of the Building, that number of parking stalls indicated in Subparagraph 15 of the
Fundamental Lease Provisions without additional charge unless required by law. The parking stalls
allotted to Tenant are located in the underground parking garage of the Building. Tenant shall not
use the garage for storage of any items and vehicles shall not be parked overnight in the parking
garage without Landlord’s prior written consent.

48. OPTION TO EXTEND THE LEASE TERM.

xxix

 

     A. Grant and Exercise of Option: Landlord grants to Tenant, subject to the terms and
conditions set forth in this Paragraph, an option (the “Option”) to extend the Lease Term for one
(1) additional term (“Option Term”). The Option Term shall be for the period set forth in
Subparagraph 17 of the Fundamental Lease Provisions above and shall be exercised, if at all, by
written notice to Landlord no earlier than fifteen (15) months and no later than twelve (12) months
prior to the Expiration Date. If Tenant exercises the Option, all of the terms, covenants and
conditions of this Lease shall apply during the Option Term as though the expiration date of the
Option Term was the date originally set forth herein as the Expiration Date, provided that Base
Rent for the Premises payable by Tenant during the Option Term shall be, unless otherwise agreed in
writing, the greater of either the Base Rent applicable to the month immediately prior to the
commencement of the Option Term, or the Fair Market Rental as hereinafter defined. Notwithstanding
anything herein to the contrary, if an Event of Default by Tenant exists either at the time Tenant
exercises the Option or at the commencement date of the Option Term, Landlord shall have, in
addition to all of Landlord’s other rights and remedies provided in this Lease, the right to
terminate the Options upon notice to Tenant, in which event the expiration date of this Lease shall
be and remain the Expiration Date. As used herein, the term “Fair Market Rental” is defined as the
rental and all other monetary payments, including any escalations and adjustments thereto
(including without limitation Consumer Price Indexing) and after giving effect to market
concessions such as free rent and tenant improvement allowance and other inducements that Landlord
could obtain during the Option Term from a third party desiring to lease the Premises, based upon
the current use and other potential uses of the Premises, as determined by the rents then being
obtained for new leases of space comparable in age, buildout and quality to the Premises in the
locality of the Premises. Fair Market Rental shall further take into account that Tenant is in
occupancy and making functional use of the Premises in its then existing condition.

     B. Determination of Fair Market Rental: If Tenant exercises the Option, Landlord
shall send Tenant a notice setting forth the Fair Market Rental for the Option Term within thirty
(30) days following the Exercise Date. If Tenant disputes Landlord’s determination of Fair Market
Rental for the Option Term, Tenant shall, within thirty (30) days after the date of Landlord’s
notice setting forth Fair Market Rental for the Option Term, send to Landlord a notice stating that
Tenant either elects to terminate its exercise of the Option, in which event the Option shall lapse
and this Lease shall terminate on the Expiration Date, or that Tenant disagrees with Landlord’s
determination of Fair Market Rental for the Option Term and elects to resolve the disagreement as
provided below. If Tenant does not send Landlord a notice as provided in the previous sentence,
Landlord’s determination of Fair Market Rental shall be the basis for determining the Base Rent
payable by Tenant during the Option Term. If Tenant elects to resolve the disagreement as provided
below and such procedures are not concluded prior to the commencement date of the Option Term,
Tenant shall pay to Landlord as Base Rent the Fair Market Rental as determined by Landlord in the
manner provided above. If the Fair Market Rental as finally determined pursuant to the provisions
set forth below is greater than Landlord’s determination, Tenant shall pay Landlord the difference
between the amount paid by Tenant and the Fair Market Rental as so determined within thirty (30)
days after said determination. If the Fair Market Rental as finally determined is less than
Landlord’s determination, the difference between the amount paid by Tenant and the Fair Market
Rental as so determined shall be credited against the next installments of Base Rent due from
Tenant to Landlord hereunder.

     C. Resolution of a Disagreement over the Fair Market Rental: Any disagreement
regarding the Fair Market Rental shall be resolved as follows:

          1. Within thirty (30) days after Tenant’s response to Landlord’s notice setting for the Fair
Market Rental, Landlord and Tenant shall meet at least two (2) times at a mutually agreeable time
and place, in an attempt to resolve the disagreement.

          2. If within the 30 day period referred to above, Landlord and Tenant cannot reach agreement
as to Fair Market Rental, each party shall select one appraiser to determine Fair Market

xxx

 

Rental.
Each such appraiser shall arrive at a determination of Fair Market Rental and submit their
conclusions to Landlord and Tenant within thirty (30) days after the expiration of the 30 day
consultation period described above.

          3. If only one appraisal is submitted within the requisite time period, it shall be deemed as
Fair Market Rental. If both appraisals are submitted within such time period and the two
appraisals so submitted differ by less than ten percent (10%), the average of the two shall be
deemed as Fair Market Rental. If the two appraisals differ by more than 10%, the appraisers shall
immediately select a third appraiser who shall, within fifteen (15) days after his selection,
determine which of the two
appraisals most closely represents the Fair Market Rental and this appraisal shall be deemed
Fair Market Rental.

          4. All appraisers specified pursuant to this Paragraph shall be members of the American
Institute of Real Estate Appraisers with not less than ten (10) years recent experience appraising
office properties in the immediate geographic area of the Building. Each party shall pay the cost
of the appraiser selected by such party and one-half of the cost of the third appraiser. The
“immediate geographic area of the Building” shall mean the cities of Palo Alto and Menlo Park.

          5. Promptly after determination of the Fair Market Rental, the parties shall execute an
amendment to this Lease incorporating such Rent with respect to the Option Term.

xxxi

 

IN WITNESS WHEREOF, the parties have executed this Lease the day and year first above written which
shall constitute the Effective Date of the Lease.

	 	 	 	 	 	 	 
	LANDLORD	 	 	 	TENANT
	400 HAMILTON ASSOCIATES, a 

California limited partnership	 	 	 	Hercules Technology Growth Capital, a

California corporation
	 
	 	 	 	 	 	 
	By

	 	/s/ Charles J. Keenan III
	 	By:
	 	/s/ Manuel A. Henriquez
	 

	 	 
	 	 	 	 
	 

	 	Charles J. Keenan III, Trustee for the Amended and
	 	Name:
	 	 Manuel A. Henriquez
	 

	 	Restated Keenan Declaration of Trust dated February 17,
	 	Title:
	 	Chief Executive Officer and President
	 

	 	1998,General Partner	 	 	 	 
	 
	 	 	 	 	 	 
	By

	 	/s/ Mark T. Gates
	 	By:
	 	/s/ David M. Lund
	 

	 	 
	 	 	 	 
	 

	 	Mark T. Gates, Trustee of the Mark T. Gates and Elizabeth W.
	 	Name:
	 	 David M. Lund
	 

	 	Gates Living Trust Agreement dated September 10, 1993,
	 	Title:
	 	 Chief Financial Officer
	 

	 	General Partner	 	 	 	 
	 
	 	 	 	 	 	 
	By

	 	/s/ Elizabeth W. Gates	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Elizabeth W. Gates, Trustee of the Mark T. Gates and Elizabeth	 	 	 	 
	 

	 	W. Gates Living Trust Agreement dated September 10, 1993,	 	 	 	 
	 

	 	General Partner	 	 	 	 

xxxiiexv10w1

 

EXHIBIT 10.1

 

SANTARUS, INC.

LOAN AND SECURITY AGREEMENT

 

 

 

     This LOAN AND SECURITY AGREEMENT (this “Agreement”) is entered into as of July 28, 2006, by
and between COMERICA BANK (“Bank”) and SANTARUS, INC. (“Borrower”).

RECITALS

     Borrower wishes to obtain credit from time to time from Bank, and Bank desires to extend
credit to Borrower. This Agreement sets forth the terms on which Bank will advance credit to
Borrower, and Borrower will repay the amounts owing to Bank.

AGREEMENT

     The parties agree as follows:

     1. DEFINITIONS AND CONSTRUCTION.

          1.1 Definitions. As used in this Agreement, the following terms shall have the
following definitions:

               “Accounts” means all presently existing and hereafter arising accounts, contract rights,
payment intangibles, and all other forms of obligations owing to Borrower arising out of the sale
or lease of goods (including, without limitation, the licensing of software and other technology)
or the rendering of services by Borrower, whether or not earned by performance, and any and all
credit insurance, guaranties, and other security therefor, as well as all merchandise returned to
or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing.

               “Advance” or “Advances” means a cash advance or cash advances under the Revolving Line.

               “Affiliate” means, with respect to any Person, any Person that owns or controls directly or
indirectly such Person, any Person that controls or is controlled by or is under common control
with such Person, and each of such Person’s senior executive officers, directors, and its general
partners, if any.

               “Bank Expenses” means (subject to reasonable documentation thereof) all out-of-pocket:
reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred in
connection with the preparation, negotiation, administration, and enforcement of the Loan
Documents; reasonable Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses
incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of
appeal), incurred by or for the benefit of Bank before, during and after an Insolvency Proceeding,
whether or not suit is brought.

               “Borrower State” means Delaware, the state under whose laws Borrower is organized.

               “Borrower’s Books” means all of Borrower’s books and records including: ledgers; records
concerning Borrower’s assets or liabilities, the Collateral, business operations or financial
condition; and all computer programs, or tape files, and the equipment, containing such
information.

               “Borrowing Base” means an amount equal to eighty percent (80%) of Eligible Accounts, as
reasonably determined by Bank with reference to the most recent Borrowing Base Certificate
delivered by Borrower.

               “Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in
the State of California are authorized or required to close.

               “Cash” means unrestricted cash, cash equivalents and marketable securities.

- 1 -

 

               “Cash Burn” means net loss (determined in accordance with GAAP), plus depreciation and
amortization, minus any decrease in deferred revenue, plus any increase in deferred revenue, plus
stock-based compensation expensed in accordance in GAAP, during the four (4) month period ending on
the measurement date, divided by four (4).

               “Change in Control” shall mean a transaction in which any “person” or “group” (within the
meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the
“beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly
or indirectly, of a sufficient number of shares of all classes of stock then outstanding of
Borrower ordinarily entitled to vote in the election of directors, empowering such “person” or
“group” to elect a majority of the Board of Directors of Borrower, who did not have such power
before such transaction.

               “Chief Executive Office State” means California, where Borrower’s chief executive office is
located.

               “Closing Date” means the date of this Agreement.

               “Code” means the California Uniform Commercial Code, as amended or supplemented from time to
time.

               “Collateral” means the property described on Exhibit A attached hereto and all Negotiable
Collateral to the extent not described on Exhibit A, except to the extent any such property (i) is
nonassignable by its terms without the consent of the licensor thereof or another party (but only
to the extent such prohibition on transfer is enforceable under applicable law, including, without
limitation, Sections 9406 and 9408 of the Code), or (ii) the granting of a security interest
therein is contrary to applicable law, provided that upon the cessation of any such restriction or
prohibition, such property shall automatically become part of the Collateral; provided that in no
case shall the definition of “Collateral” exclude any Accounts, proceeds of the disposition of any
property, or general intangibles consisting of rights to payment.

               “Collateral State” means: the state or states in the United States where the Collateral is
located (other than: personal property used to support field services and marketing operations,
having an aggregate book value of less than Five Hundred Thousand Dollars ($500,000); and
Collateral located in Canada, provided that such Collateral shall not have a book value in excess
of One Million Dollars ($1,000,000) at any time), which are California, Kentucky and New York.

               “Consolidated Net Income (or Deficit)” means the consolidated net income (or deficit) of any
Person and its Subsidiaries, after deduction of all expenses, taxes, and other proper charges,
determined in accordance with GAAP, after eliminating therefrom all extraordinary nonrecurring
items of income and expense (subject to Bank’s prior review and reasonable approval of such
proposed extraordinary items).

               “Consolidated Total Interest Expense” means with respect to any Person for any period, the
aggregate amount of interest required to be paid or accrued by a Person and its Subsidiaries during
such period on all Indebtedness of such Person and its Subsidiaries outstanding during all or any
part of such period, whether such interest was or is required to be reflected as an item of expense
or capitalized, including payments consisting of interest in respect of any capitalized lease or
any synthetic lease, and including commitment fees, agency fees, facility fees, balance deficiency
fees and similar fees or expenses in connection with the borrowing of money.

               “Contingent Obligation” means, as applied to any Person, any direct or indirect liability,
contingent or otherwise, of that Person with respect to (i) any indebtedness, capital lease,
dividend, letter of credit or other obligation of another, including, without limitation, any such
obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse
by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii)
any obligations with respect to undrawn letters of credit, corporate credit cards, or merchant
services issued for the account of that Person; and (iii) all obligations arising under any
interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate
collar agreement, or other agreement or arrangement designated to protect a Person against
fluctuation in interest rates, currency exchange

- 2 -

 

rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not
include endorsements for collection or deposit in the Ordinary Course of Business. The amount of
any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount
of the primary obligation in respect of which such Contingent Obligation is made or, if not stated
or determinable, the maximum reasonably anticipated liability in respect thereof as determined by
such Person in good faith; provided, however, that such amount shall not in any event exceed the
maximum amount of the obligations under the guarantee or other support arrangement.

               “Copyrights” means any and all copyright rights, copyright applications, copyright
registrations and like protections in each work or authorship and derivative work thereof, whether
published or unpublished and whether or not the same also constitutes a trade secret, now or
hereafter existing, created, acquired or held.

               “Credit Extension” means each Advance or any other extension of credit by Bank to or for the
benefit of Borrower hereunder.

               “EBITDA” means with respect to any fiscal period an amount equal to the sum of (a)
Consolidated Net Income of the Borrower and its Subsidiaries for such fiscal period, plus (b) in
each case to the extent deducted in the calculation of the Borrower’s Consolidated Net Income and
without duplication, (i) depreciation and amortization for such period, plus (ii) income tax
expense for such period, plus (iii) Consolidated Total Interest Expense paid or accrued during such
period, plus (iv) stock-based compensation expensed in accordance with GAAP, and minus, to the
extent added in computing Consolidated Net Income, and without duplication, all extraordinary and
non-recurring revenue and gains and expenses (including income tax benefits) (subject, in all
events, to Bank’s prior review and reasonable approval of such proposed extraordinary items) for
such period, all as determined in accordance with GAAP.

               “Eligible Accounts” means those Accounts that arise in the Ordinary Course of Business that
comply with all of Borrower’s representations and warranties to Bank set forth in Section 5.3;
provided that, as the result of an audit of the Collateral which is unsatisfactory to Bank in its
reasonable discretion, or an Event of Default, Bank may change the standards of eligibility by
giving Borrower thirty (30) days prior written notice. Unless otherwise agreed to by Bank,
Eligible Accounts shall not include the following:

               (a) Accounts that the account debtor has failed to pay in full within (x) sixty (60) days of
due date with respect to Accounts payable on terms consistent with Borrower’s Trade Policy; and (y)
ninety (90) days of invoice date on all other Accounts;

               (b) Credit balances over (x) sixty (60) days with respect to Accounts payable on terms
consistent with Borrower’s Trade Policy; and (y) ninety (90) days on all other Accounts;

               (c) Accounts with respect to an account debtor, twenty-five percent (25%) of whose Accounts
the account debtor has failed to pay within (x) sixty (60) days of due date with respect to
Accounts payable on terms consistent with Borrower’s Trade Policy; and (y) ninety (90) days of
invoice date on all other Accounts;

               (d) Accounts with respect to an account debtor, including Subsidiaries and Affiliates, whose
total obligations to Borrower exceed twenty five percent (25%) of all Accounts, to the extent such
obligations exceed the aforementioned percentage; except for Accounts of McKesson Corporation,
AmerisourceBergen Corporation and Cardinal Health, Inc. (and each of their Affiliates), to the
extent the obligations (of each such Account) exceed fifty percent (50%) of all Accounts; except as
approved in writing by Bank;

               (e) Accounts with respect to which the account debtor does not have its principal place of
business in the United States, except for Eligible Foreign Accounts;

               (f) Accounts with respect to which the account debtor is the United States or any department,
agency, or instrumentality of the United States, except for Accounts of the United States if the
payee

- 3 -

 

has assigned its payment rights to Bank and the assignment has been acknowledged under the
Assignment of Claims Act of 1940 (31 U.S.C. 3727);

               (g) Accounts with respect to which Borrower is liable to the account debtor for goods sold or
services rendered by the account debtor to Borrower, but only to the extent of any amounts owing to
the account debtor against amounts owed to Borrower;

               (h) Accounts with respect to which goods are placed on consignment, guaranteed sale, sale or
return, sale on approval, bill and hold, demo or promotional, or other terms by reason of which the
payment by the account debtor may be conditional (other than Accounts subject to return as a result
of product damage or expiration, in accordance Borrower’s Trade Policy);

               (i) Accounts with respect to which the account debtor is an officer, employee or Affiliate of
Borrower;

               (j) Accounts that have not yet been billed to the account debtor or that relate to deposits
(such as good faith deposits) or other property of the account debtor held by Borrower for the
performance of services or delivery of goods which Borrower has not yet performed or delivered;

               (k) Accounts with respect to which the account debtor disputes liability or makes any claim
with respect thereto as to which Bank believes, in its sole discretion, that there may be a basis
for dispute (but only to the extent of the amount subject to such dispute or claim), or is subject
to any Insolvency Proceeding, or becomes insolvent, or goes out of business;

               (l) Accounts the collection of which Bank reasonably determines after inquiry and consultation
with Borrower to be doubtful; and

               (m) Retentions and hold-backs.

               “Eligible Foreign Accounts” means Accounts with respect to which the account debtor does not
have its principal place of business in the United States and that are (i) supported by one or more
letters of credit in an amount and of a tenor, and issued by a financial institution, acceptable to
Bank, (ii) insured by the Export Import Bank of the United States, (iii) generated by an account
debtor with its principal place of business in Canada, provided that the Bank has perfected its
security interest in the appropriate Canadian province, or (iv) approved by Bank on a case-by-case
basis. All Eligible Foreign Accounts must be calculated in U.S. Dollars.

               “Environmental Laws” means all laws, rules, regulations, orders and the like issued by any
federal state, local foreign or other governmental or quasi-governmental authority or any agency
pertaining to the environment or to any hazardous materials or wastes, toxic substances, flammable,
explosive or radioactive materials, asbestos or other similar materials.

               “Equipment” means all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest.

               “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the
regulations thereunder.

               “Event of Default” has the meaning assigned in Article 8.

               “GAAP” means generally accepted accounting principles, consistently applied, as in effect from
time to time.

               “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of
property or services, including without limitation reimbursement and other obligations with respect
to surety

- 4 -

 

bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or
similar instruments, (c) all capital (but not operating) lease obligations, and (d) all Contingent
Obligations.

               “Insolvency Proceeding” means any proceeding commenced by or against any Person or entity
under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy
or insolvency law, including assignments for the benefit of creditors, formal or informal
moratoria, compositions, extension generally with its creditors, or proceedings seeking
reorganization, arrangement, or other relief.

               “Intellectual Property” means all of Borrower’s right, title, and interest in and to the
following:

               (a) Copyrights, Trademarks and Patents;

               (b) Any and all trade secrets, and any and all Intellectual Property rights in computer
software and computer software products now or hereafter existing, created, acquired or held;

               (c) Any and all design rights which may be available to Borrower now or hereafter existing,
created, acquired or held;

               (d) Any and all claims for damages by way of past, present and future infringement of any of
the rights included above, with the right, but not the obligation, to sue for and collect such
damages for said use or infringement of the Intellectual Property rights identified above;

               (e) All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all
license fees and royalties arising from such use to the extent permitted by such license or rights;

               (f) All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents;
and

               (g) All proceeds of the foregoing, including without limitation all payments under insurance
or any indemnity or warranty payable in respect of any of the foregoing.

               “Inventory” means all present and future inventory in which Borrower has any interest.

               “Investment” means any beneficial ownership of (including stock, partnership or limited
liability company interest other securities) any Person, or any loan, advance or capital
contribution to any Person.

               “IRC” means the Internal Revenue Code of 1986, as amended, and the regulations thereunder.

               “Letter of Credit” means a commercial or standby letter of credit or similar undertaking
issued by Bank at Borrower’s request.

               “LIBOR Addendum” means that certain LIBOR Addendum to Loan and Security Agreement executed by
and between Borrower and Bank of even date herewith.

               “Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other
encumbrance.

               “Liquidity” means the sum of Cash at Bank (or Bank’s Affiliates or other third parties, in
each case subject to a control agreement in form and content reasonably acceptable to Bank and
provided the Bank can view the accounts’ balances on a daily basis), plus the Borrowing Base.

- 5 -

 

               “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower,
and any other document, instrument or agreement entered into in connection with this Agreement, all
as amended or extended from time to time.

               “Material Adverse Effect” means a material adverse effect on (i) the business operations,
condition (financial or otherwise) or prospects of Borrower and its Subsidiaries taken as a whole,
(ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under
the Loan Documents, (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s
security interest in the Collateral.

               “Negotiable Collateral” means all of Borrower’s present and future letters of credit of which
it is a beneficiary, drafts, instruments (including promissory notes), securities, documents of
title, and chattel paper, and Borrower’s Books relating to any of the foregoing.

               “Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to
Bank by Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent,
due or to become due, now existing or hereafter arising, including any interest that accrues after
the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing
from Borrower to others that Bank may have obtained by assignment or otherwise.

               “Ordinary Course of Business” means, with respect to Borrower and any transaction, agreement
or other matter, engaging in the usual and customary business of a specialty pharmaceutical company
similar to Borrower in size (financial and otherwise) and business strategy (as of the Closing Date
and as contemplated as of the Closing Date), including but not limited to, entering into or
amending arrangements relating to collaborations, joint ventures, strategic alliances, product
acquisitions and the development, manufacture and commercialization of pharmaceutical products
(including but not limited to the license (exclusive only as to duration, market segment and/or
geography) and sublicense of Intellectual Property in arms’ length transactions on fair and
reasonable terms); in each case, provided the same could not reasonably be expected to have a
Material Adverse Effect and provided further that an Event of Default has not occurred and is not
continuing before and could not reasonably be expected to occur after giving effect to such
transaction, agreement or other matter.

               “Patents” means all patents, patent applications and like protections including without
limitation improvements, divisions, continuations, renewals, reissues, extensions and
continuations-in-part of the same.

               “Periodic Payments” means all installments or similar recurring payments that Borrower may now
or hereafter become obligated to pay to Bank pursuant to the terms and provisions of any
instrument, or agreement now or hereafter in existence between Borrower and Bank.

               “Permitted Indebtedness” means:

               (a) Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan
Document;

               (b) Indebtedness existing on the Closing Date and disclosed in the Schedule;

               (c) Indebtedness not to exceed One Million Five Hundred Thousand Dollars ($1,500,000) in the
aggregate in any fiscal year of Borrower secured by a lien described in clause (c) of the defined
term “Permitted Liens;” provided such Indebtedness does not exceed the lesser of the cost or fair
market value of the equipment financed with such Indebtedness;

               (d) Without duplication with (c), above, or clause (d) of the defined term “Permitted Liens,”
Indebtedness with respect to capital leases not to exceed Five Million Dollars ($5,000,000) in the
aggregate outstanding, resulting solely from (x) changes to GAAP which require the conversion of
leases considered “operating leases” as of the Closing Date to “capital leases” as of any future
date or (y) Borrower’s determination to finance or refinance assets subject to operating leases as
of the Closing Date with capital leases;

- 6 -

 

               (e) Subordinated Debt;

               (f) Indebtedness to trade creditors incurred in the Ordinary Course of Business;

               (g) Indebtedness of Borrower which (i) is convertible into shares of common stock of Borrower;
(ii) is unsecured, (iii) provides for principal payment only after the Revolving Maturity Date; and
(iv) may or may not be Subordinated Debt; and

               (h) Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided
that the principal amount is not increased or the terms modified in any material respect to impose
more burdensome terms upon Borrower or its Subsidiary, as the case may be.

               “Permitted Investment” means:

               (a) Investments existing on the Closing Date disclosed in the Schedule; and

               (b) (i) Marketable direct obligations issued or unconditionally guaranteed by the United
States of America or any agency or any State thereof maturing within one (1) year from the date of
acquisition thereof, (ii) commercial paper maturing no more than one (1) year from the date of
creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s
Corporation or Moody’s Investors Service, (iii) Bank’s certificates of deposit maturing no more
than one year from the date of investment therein, (iv) Bank’s money market accounts, and (v)
Investments made in accordance with Borrower’s investment policy approved from time to time by
Borrower’s board of directors and provided to (and, to the extent amended after the Closing Date,
approved by) Bank;

               (c) Repurchases of stock from former employees or directors of Borrower under the terms of
applicable repurchase agreements (i) in an aggregate amount not to exceed Two Million Five Hundred
Thousand Dollars ($2,500,000) in any fiscal year, provided that no Event of Default has occurred,
is continuing or would exist after giving effect to the repurchases, or (ii) in any amount where
the consideration for the repurchase is the cancellation of indebtedness owed by such former
employees to Borrower regardless of whether an Event of Default exists;

               (d) Investments accepted in connection with Permitted Transfers;

               (e) Investments of Subsidiaries in or to other Subsidiaries or Borrower and Investments by
Borrower in Subsidiaries not to exceed Five Hundred Thousand Dollars ($500,000) in the aggregate in
any fiscal year;

               (f) Investments not to exceed Five Hundred Thousand Dollars ($500,000) in the aggregate in any
fiscal year consisting of (i) travel advances and employee relocation loans and other employee
loans and advances in the Ordinary Course of Business, and (ii) loans to employees, officers or
directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant to
stock option plan agreements (and similar agreements) approved by Borrower’s Board of Directors;

               (g) Investments (including debt obligations) received in connection with the bankruptcy or
reorganization of customers or suppliers and in settlement of delinquent obligations of, and other
disputes with, customers or suppliers arising in the Ordinary Course of Business;

               (h) Investments consisting of notes receivable of, or prepaid royalties and other credit
extensions, to customers and suppliers who are not Affiliates, in the Ordinary Course of Business,
provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary;
and

               (i) Transactions, agreements or other matters entered into in the Ordinary Course of Business.

- 7 -

 

               “Permitted Liens” means:

               (a) Any Liens existing on the Closing Date and disclosed in the Schedule or arising under this
Agreement or the other Loan Documents;

               (b) Liens for taxes, fees, assessments or other governmental charges or levies, either not
delinquent or being contested in good faith by appropriate proceedings and for which Borrower
maintains adequate reserves, provided the same have no priority over any of Bank’s security
interests;

               (c) Liens not to exceed One Million Five Hundred Thousand Dollars ($1,500,000) in the
aggregate in any fiscal year (i) upon or in any Equipment acquired or held by Borrower or any of
its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for
the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such
Equipment at the time of its acquisition, provided that the Lien is confined solely to the property
so acquired and improvements thereon, and the proceeds of such Equipment;

               (d) Without duplication with (c), above, or clause (d) of the defined term “Permitted
Indebtedness,” Liens securing capital leases not to exceed Five Million Dollars ($5,000,000) in the
aggregate outstanding, resulting solely from (x) changes to GAAP which require the conversion of
leases considered “operating leases” as of the Closing Date to “capital leases” as of any future
date or (y) Borrower’s determination to finance or refinance assets subject to operating leases as
of the Closing Date with capital leases;

               (e) Liens incurred in connection with the extension, renewal or refinancing of the
indebtedness secured by Liens of the type described in clauses (a) through (c) above, provided that
any extension, renewal or replacement Lien shall be limited to the property encumbered by the
existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced
does not increase in any material respect;

               (f) Liens arising from judgments, decrees or attachments in circumstances not constituting an
Event of Default under Sections 8.5 or 8.9;

               (g) Liens of materialmen, mechanics, warehousemen, carriers, artisans or other similar Liens
arising in the Ordinary Course of Business or by operation of law, which are not past due or which
are being contested in good faith by appropriate proceedings and for which reserves have been
established in accordance with GAAP; and

               (h) Liens in favor of other financial institutions arising in connection with Borrower’s
deposit accounts held at such institutions to secure standard fees for deposit services charged by,
but not financing made available by such institutions, provided that Bank has a perfected security
interest in the amounts held in such deposit accounts.

               “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or
any Subsidiary of:

               (a) Inventory in the Ordinary Course of Business;

               (b) licenses and similar arrangements for the use of the Intellectual Property of Borrower or
its Subsidiaries in the Ordinary Course of Business;

               (c) worn-out or obsolete Equipment;

               (d) transfers of Borrower’s assets in the Ordinary Course of Business; or

               (e) other assets of Borrower or its Subsidiaries that do not in the aggregate exceed Five
Hundred Thousand Dollars ($500,000) during any fiscal year.

- 8 -

 

               “Person” means any individual, sole proprietorship, partnership, limited liability company,
joint venture, trust, unincorporated organization, association, corporation, institution, public
benefit corporation, firm, joint stock company, estate, entity or governmental agency.

               “Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank,
as its “prime rate,” whether or not such announced rate is the lowest rate available from Bank.

               “Profitability” means net income after tax, calculated in accordance with GAAP, plus
stock-based compensation expensed in accordance with GAAP.

               “Responsible Officer” means each of the Chief Executive Officer and the Chief Financial
Officer of Borrower.

               “Revolving Line” means a Credit Extension of up to Twenty Million Dollars ($20,000,000).

               “Revolving Maturity Date” means July 28, 2009.

               “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any,
including any updates thereto in accordance with Section 3.2(b).

               “SOS Reports” means the official reports from the Secretaries of State of each Collateral
State, Chief Executive Office State and the Borrower State and other applicable federal, state or
local government offices identifying all current security interests filed in the Collateral and
Liens of record as of the date of such report.

               “Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the
debt owing by Borrower to Bank on terms reasonably acceptable to Bank (and identified as being such
by Borrower and Bank).

               “Subsidiary” means any corporation, partnership or limited liability company or joint venture
in which (i) any general partnership interest or (ii) more than fifty percent (50%) of the stock,
limited liability company interest or joint venture of which by the terms thereof has the ordinary
voting power to elect the Board of Directors, managers or trustees of the entity, at the time as of
which any determination is being made, is owned by Borrower, either directly or through an
Affiliate.

               “Trademarks” means any trademark and servicemark rights, whether registered or not,
applications to register and registrations of the same and like protections, and the entire
goodwill of the business of Borrower connected with and symbolized by such trademarks.

               “Trade Policy” means Borrower’s policy with respect to damaged and/or expired products, as set
forth in that certain “Santarus, Inc. Trade Policy” in effect (and as contemplated) as of the
Closing Date, attached hereto as Annex I (and as amended from time to time, as approved by Bank).

          1.2 Accounting Terms. Any accounting term not specifically defined herein shall be
construed in accordance with GAAP and all calculations shall be made in accordance with GAAP. The
term “financial statements” shall include, with respect to annual and quarterly financial
statements (unless otherwise required by the SEC), the accompanying notes and schedules.

     2. LOAN AND TERMS OF PAYMENT.

          2.1 Credit Extensions.

               (a) Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United
States of America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to

- 9 -

 

Borrower, together with interest on the unpaid principal amount of such Credit Extensions at
rates in accordance with the terms hereof.

               (b) Advances Under Revolving Line.

                    (i) Amount. Subject to and upon the terms and conditions of this Agreement, and, when
Advances are made against the Borrowing Base, subject to an audit of the Collateral the results of
which shall be satisfactory to Bank, (1) Borrower may request Advances, subject to Section 6.7(b)
in an aggregate outstanding amount not to exceed the Revolving Line, and (2) amounts borrowed
pursuant to this Section 2.1(b) may be repaid and reborrowed at any time prior to the Revolving
Maturity Date, at which time all Advances under this Section 2.1(b) shall be immediately due and
payable. Except as set forth in the LIBOR Addendum, Borrower may prepay any Advances without
penalty or premium.

                    (ii) Form of Request. Whenever Borrower desires an Advance, Borrower will notify Bank
by facsimile transmission or email no later than 3:00 p.m. Pacific time (1:00 p.m. Pacific time for
wire transfers), on the Business Day that the Advance is to be made. Each such notification shall
be promptly confirmed by a Loan Advance/Paydown Request Form in substantially the form of Exhibit B
hereto. Bank is authorized to make Advances under this Agreement, based upon instructions received
from a Responsible Officer or a designee of a Responsible Officer, or without instructions (but
with notice to Borrower) if in Bank’s discretion such Advances are necessary to meet Obligations
which have become due and remain unpaid. Bank shall be entitled to rely on any facsimile or email
notice given by a person who Bank reasonably believes to be a Responsible Officer or a designee
thereof, and Borrower shall indemnify and hold Bank harmless for any damages or loss suffered by
Bank as a result of such reliance. Bank will credit the amount of Advances made under this Section
2.1(b) to Borrower’s deposit account.

          2.2 Overadvances. If the aggregate amount of the outstanding Advances exceeds the
lesser of the Revolving Line or, subject to Section 6.7(b), the Minimum Liquidity Ratio at any
time, Borrower shall immediately pay to Bank, in cash, the amount of such excess.

          2.3 Interest Rates, Payments, and Calculations.

               (a) Interest Rates. Except as set forth in Section 2.3(b), the Advances shall bear
interest, on the outstanding daily balance thereof, as set forth in the LIBOR Addendum.

               (b) Default Rate. All Obligations shall bear interest, from and after the occurrence
and during the continuance of an Event of Default, at a rate equal to three (3) percentage points
above the interest rate applicable immediately prior to the occurrence of the Event of Default.

               (c) Payments. Interest hereunder shall be due and payable in arrears on the first
calendar day of each month during the term hereof. Bank shall, at its option, charge such
interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts
or, in the event of insufficient funds in such accounts, against the Revolving Line, in which case
those amounts shall thereafter accrue interest at the rate then applicable hereunder. Any interest
not paid when due (other than as a result of Bank’s failure to debit Borrower’s deposit accounts
when such accounts have sufficient funds) shall be compounded by becoming a part of the
Obligations, and such interest shall thereafter accrue interest at the rate then applicable
hereunder.

               (d) Computation. In the event the Prime Rate is changed from time to time hereafter,
the applicable rate of interest hereunder shall be increased or decreased, effective as of the day
the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest
chargeable under the Loan Documents shall be computed on the basis of a three hundred sixty (360)
day year for the actual number of days elapsed.

          2.4 Crediting Payments. Prior to the occurrence of an Event of Default, Bank shall
credit a wire transfer of funds, check or other item of payment to such deposit account or
Obligation as Borrower specifies. After the occurrence and during the continuance of an Event of
Default, Bank shall have the right, in its sole

- 10 -

 

discretion, to immediately apply any wire transfer of funds, check, or other item of payment
to conditionally reduce Obligations, but such applications of funds shall not be considered a
payment on account unless such payment is of immediately available federal funds or unless and
until such check or other item of payment is honored when presented for payment. Notwithstanding
anything to the contrary contained herein, any wire transfer or payment received by Bank after
12:00 noon Pacific time shall be deemed to have been received by Bank as of the opening of business
on the immediately following Business Day. Whenever any payment to Bank under the Loan Documents
would otherwise be due (except by reason of acceleration) on a date that is not a Business Day,
such payment shall instead be due on the next Business Day, and additional fees or interest, as the
case may be, shall accrue and be payable for the period of such extension.

          2.5 Fees. Borrower shall pay to Bank the following:

               (a) Facility Fee. On the Closing Date, a fee equal to $25,000, which shall be
nonrefundable; and

               (b) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the
Closing Date, and, after the Closing Date, all Bank Expenses as and when they become due.

          2.6 Term. This Agreement shall become effective on the Closing Date and, subject to
Section 13.7, shall continue in full force and effect for so long as any Obligations remain
outstanding or Bank has any obligation to make Credit Extensions under this Agreement.
Notwithstanding the foregoing, Bank shall have the right to terminate its obligation to make Credit
Extensions under this Agreement immediately and without notice upon the occurrence and during the
continuance of an Event of Default. Borrower shall have the right to terminate this Agreement upon
thirty (30) days prior written notice to Bank and indefeasible payment in full of the Obligations.

     3. CONDITIONS OF LOANS.

          3.1 Conditions Precedent to Initial Credit Extension. The obligation of Bank to make
the initial Credit Extension is subject to the condition precedent that Bank shall have received,
in form and substance satisfactory to Bank, the following:

               (a) this Agreement;

               (b) the LIBOR Addendum;

               (c) an officer’s certificate of Borrower with respect to incumbency and resolutions
authorizing the execution and delivery of this Agreement;

               (d) UCC National Form Financing Statement;

               (e) current SOS Reports indicating that except for Permitted Liens, there are no other
security interests or Liens of record in the Collateral;

               (f) securities and/or deposit account control agreements with respect to any accounts
permitted hereunder to be maintained outside Bank;

               (g) agreement to provide insurance;

               (h) payment of the fees and Bank Expenses then due specified in Section 2.5 hereof;

               (i) current financial statements, including audited statements for Borrower’s most recently
ended fiscal year, together with an unqualified opinion, company prepared consolidated balance
sheets and income statements for the most recently ended quarter (as filed with the Securities and
Exchange Commission (the

- 11 -

 

“SEC”)) in accordance with Section 6.2, and such other updated financial information as Bank
may reasonably request;

               (j) current Compliance Certificate in accordance with Section 6.2; and

               (k) such other documents, certificates or opinions, and completion of such other matters, as
Bank may reasonably deem necessary or appropriate.

          3.2 Conditions Precedent to all Credit Extensions. The obligation of Bank to make
each Credit Extension, including the initial Credit Extension, is further subject to the following
conditions:

               (a) timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in Section
2.1; and

               (b) the representations and warranties contained in Section 5 shall be true and correct in all
material respects on and as of the date of such Loan Advance/Paydown Request Form and on the
effective date of each Credit Extension as though made at and as of each such date, and no Event of
Default shall have occurred and be continuing, or would exist after giving effect to such Credit
Extension (provided, however, that those representations and warranties expressly referring to
another date shall be true, correct and complete in all material respects as of such date). The
making of each Credit Extension shall be deemed to be a representation and warranty by Borrower on
the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2.
Notwithstanding the foregoing, after the initial Credit Extension, Borrower may update such
representations and warranties by amending the Schedule attached hereto for events or circumstances
arising after the initial Credit Extension so long as Bank reviews and approves such updated
information, which information could not reasonably be expected to have a Material Adverse Effect.

     4. CREATION OF SECURITY INTEREST.

          4.1 Grant of Security Interest. Borrower grants and pledges to Bank a continuing
security interest in the Collateral to secure prompt repayment of any and all Obligations and in
order to secure prompt performance by Borrower of each of its covenants and duties under the Loan
Documents. Except as set forth in the Schedule, such security interest constitutes a valid, first
priority security interest in the presently existing Collateral, and will constitute a valid, first
priority security interest in later-acquired Collateral. Borrower also hereby agrees to not sell,
transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its
Intellectual Property; in each case, other than in the Ordinary Course of Business.
Notwithstanding any termination, Bank’s Lien on the Collateral shall remain in effect for so long
as any Obligations are outstanding.

          4.2 Perfection of Security Interest. Borrower authorizes Bank to file at any time
financing statements, continuation statements, and amendments thereto that (i) either specifically
describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged
hereunder, and (ii) contain any other information required by the Code for the sufficiency of
filing office acceptance of any financing statement, continuation statement, or amendment,
including whether Borrower is an organization, the type of organization and any organizational
identification number issued to Borrower, if applicable. Any such financing statements may be
signed by Bank on behalf of Borrower, as provided in the Code, and may be filed at any time in any
jurisdiction whether or not Revised Article 9 of the Code is then in effect in that jurisdiction.
Borrower shall from time to time endorse and deliver to Bank, at the request of Bank, all
Negotiable Collateral and other documents that Bank may reasonably request, in form satisfactory to
Bank, to perfect and continue perfected Bank’s security interests in the Collateral and in order to
fully consummate all of the transactions contemplated under the Loan Documents. Borrower shall
have possession of the Collateral, except where expressly otherwise provided in this Agreement or
where Bank reasonably determines to perfect its security interest by possession in addition to the
filing of a financing statement. Where Collateral is in possession of a third party bailee,
Borrower shall take such steps as Bank reasonably requests for Bank to (i) obtain an
acknowledgment, in form and substance satisfactory to Bank, of the bailee that the bailee holds
such Collateral for the benefit of Bank, and (ii) obtain “control” of any Collateral consisting of
investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such
items and the term “control” are defined in Revised Article 9 of the Code) by causing the
securities intermediary or depositary institution or issuing bank to execute a control agreement in
form and substance satisfactory to Bank.

- 12 -

 

Borrower will not create any chattel paper without placing a legend on the chattel paper
acceptable to Bank indicating that Bank has a security interest in the chattel paper. Borrower
from time to time may deposit with Bank specific cash collateral to secure specific Obligations;
Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any
drafts thereon or any request by Borrower or any other Person to pay or otherwise transfer any part
of such balances for so long as the specific Obligations are outstanding.

          4.3 Right to Inspect. Bank (through any of its officers, employees, or agents) shall
have the right, upon reasonable prior notice, from time to time during Borrower’s usual business
hours but no more than once a year (unless an Event of Default has occurred and is continuing), to
inspect Borrower’s Books and to make copies thereof and to check, test, and appraise the Collateral
in order to verify Borrower’s financial condition or the amount, condition of, or any other matter
relating to, the Collateral.

     5. REPRESENTATIONS AND WARRANTIES.

          Borrower represents and warrants as follows:

          5.1 Due Organization and Qualification. Borrower and each Subsidiary is duly existing
under the laws of the state in which it is organized and qualified and licensed to do business in
any state in which the conduct of its business or its ownership of property requires that it be so
qualified, except where the failure to do so could not reasonably be expected to cause a Material
Adverse Effect.

          5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the
Loan Documents are within Borrower’s corporate powers, have been duly authorized by all necessary
corporate action on the part of Borrower, and are not in conflict with nor constitute a breach of
any provision contained in Borrower’s Certificate of Incorporation or Bylaws, nor will they
constitute an event of default under any material agreement by which Borrower is bound. Borrower
is not in default under any agreement by which it is bound, except to the extent such default could
not reasonably be expected to cause a Material Adverse Effect.

          5.3 Collateral. Borrower has rights in or the power to transfer the Collateral, and
its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on
transfer or pledge except for Permitted Liens. Other than: personal property used to support field
services and marketing operations, having an aggregate book value of less than Five Hundred
Thousand Dollars ($500,000); and Collateral located in Canada, which shall not have a book value in
excess of One Million Dollars ($1,000,000) at any time; all Collateral is located solely in the
Collateral States. The Eligible Accounts are bona fide existing obligations. The property or
services giving rise to such Eligible Accounts has been delivered or rendered to the account debtor
or its agent for immediate shipment to and unconditional acceptance by the account debtor (subject
to Borrower’s Trade Policy). Borrower has not received notice of actual or imminent Insolvency
Proceeding of any account debtor whose accounts are included in any Borrowing Base Certificate as
an Eligible Account. All Inventory is in all material respects of good and merchantable quality,
free from all material defects, except for Inventory for which adequate reserves have been made in
accordance with GAAP. Except as set forth in the Schedule, none of Borrower’s Cash is maintained
or invested with a Person other than Bank or Bank’s Affiliates.

          5.4 Intellectual Property. Borrower owns or controls the Intellectual Property
utilized in its business, except for licenses granted by Borrower in the Ordinary Course of
Business. To the best of Borrower’s knowledge, except as set forth in the Schedule, and no part of
its Intellectual Property has been judged invalid or unenforceable, in whole or in part, and no
claim has been made to Borrower that any part of its Intellectual Property violates the rights of
any third party except to the extent such claim could not reasonably be expected to cause a
Material Adverse Effect.

          5.5 Name; Location of Chief Executive Office. Except as disclosed in the Schedule,
Borrower has not done business under any name other than that specified on the signature page
hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The
chief executive office of Borrower is located in the Chief Executive Office State at the address
indicated in Section 10 hereof.

- 13 -

 

          5.6 Litigation. Except as set forth in the Schedule, there are no actions or
proceedings pending by or against Borrower or any Subsidiary before any court or administrative
agency in which a likely adverse decision could reasonably be expected to have a Material Adverse
Effect.

          5.7 No Material Adverse Change in Financial Statements. All consolidated financial
statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly
present in all material respects Borrower’s consolidated financial condition as of the date thereof
and Borrower’s consolidated results of operations for the period then ended. There has not been a
material adverse change in the consolidated or in the consolidating financial condition of Borrower
since the date of the most recent of such financial statements submitted to Bank (or available to
Bank on the SEC’s website).

          5.8 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade
debts) as they mature; the fair saleable value of Borrower’s assets (including goodwill minus
disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with
unreasonably small capital after the transactions contemplated by this Agreement.

          5.9 Compliance with Laws and Regulations. Borrower and each Subsidiary have met the
minimum funding requirements of ERISA with respect to any employee benefit plans maintained by
Borrower and subject to ERISA. No event has occurred resulting from Borrower’s failure to comply
with ERISA that is reasonably likely to result in Borrower’s incurring any liability that could
have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled”
by an “investment company” within the meaning of the Investment Company Act of 1940, as amended.
Borrower is not engaged principally, or as one of the important activities, in the business of
extending credit for the purpose of purchasing or carrying margin stock (within the meaning of
Regulations T and U of the Board of Governors of the Federal Reserve System). Borrower has
complied in all material respects with all the provisions of the Federal Fair Labor Standards Act.
Borrower is in compliance with all environmental laws, regulations and ordinances except where the
failure to comply could not reasonably be expected to have a Material Adverse Effect. Borrower has
not violated any statutes, laws, ordinances or rules applicable to it, the violation of which could
reasonably be expected to have a Material Adverse Effect. Borrower and each Subsidiary have filed
or caused to be filed all tax returns required to be filed, and have paid, or have made adequate
provision for the payment of, all taxes reflected therein except those being contested in good
faith with adequate reserves under GAAP or where the failure to file such returns or pay such taxes
could not reasonably be expected to have a Material Adverse Effect.

          5.10 Subsidiaries. Borrower does not own any stock, partnership interest or other
equity securities of any Person, except for Permitted Investments.

          5.11 Government Consents. Borrower and each Subsidiary have obtained all consents,
approvals and authorizations of, made all declarations or filings with, and given all notices to,
all governmental authorities that are necessary for the continued operation of Borrower’s business
as currently conducted, except where the failure to do so could not reasonably be expected to cause
a Material Adverse Effect.

          5.12 Inbound Licenses. Except as disclosed in the Schedule, Borrower is not a party
to, nor is bound by, any material inbound license or agreement that prohibits or otherwise
restricts Borrower from granting a security interest in Borrower’s interest in such material
inbound license or agreement or any other property.

          5.13 Full Disclosure. No representation, warranty or other statement made by Borrower
in any certificate or written statement furnished to Bank taken together with all such certificates
and written statements furnished to Bank contains any untrue statement of a material fact or omits
to state a material fact necessary in order to make the statements contained in such certificates
or statements not misleading it being recognized by Bank that the projections and forecasts
provided by Borrower in good faith and based upon reasonable assumptions are not to be viewed as
facts and that actual results during the period or periods covered by any such projections and
forecasts may differ from the projected or forecasted results.

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     6. AFFIRMATIVE COVENANTS.

          Borrower covenants and agrees that, until payment in full of all outstanding Obligations, and
for so long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do
all of the following:

          6.1 Good Standing and Government Compliance. Borrower shall maintain its and each of
its Subsidiaries’ corporate existence and good standing in the Borrower State, shall maintain
qualification and good standing in each other jurisdiction in which the failure to so qualify could
reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the
organizational identification number issued to Borrower by the authorities of the state in which
Borrower is organized, if applicable. Borrower shall meet, and shall cause each Subsidiary to
meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject
to ERISA. Borrower shall comply in all material respects with all applicable Environmental Laws,
and maintain all material permits, licenses and approvals required thereunder where the failure to
do so could have a Material Adverse Effect. Borrower shall comply, and shall cause each Subsidiary
to comply, with all statutes, laws, ordinances and government rules and regulations to which it is
subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all
licenses, approvals and agreements, the loss of which or failure to comply with which could
reasonably be expected to have a Material Adverse Effect.

          6.2 Financial Statements, Reports, Certificates. Borrower shall deliver the following
to Bank (provided that any such financial statements that are available to Bank on the SEC’s
website shall be deemed delivered without further action by Borrower): (i) as soon as available,
but in any event within one hundred twenty (120) days (or such earlier time as is required by the
SEC) after the end of Borrower’s fiscal year, audited consolidated financial statements of Borrower
prepared in accordance with GAAP, consistently applied, together with an opinion which is
unqualified or otherwise consented to in writing by Bank on such financial statements of an
independent certified public accounting firm reasonably acceptable to Bank; (ii) as soon as
available, but in any event within forty (40) days after the last day of each month when the
Liquidity Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts
(or, otherwise, forty (40) days after the end of each of Borrower’s first, second and third fiscal
quarters (or such earlier time as may be mandated by the SEC from time to time)), unaudited
financial statements of Borrower prepared in accordance with GAAP; (iii) as and when filed, all
reports on Forms 10-K and 10-Q filed with the SEC; (iv) within five (5) calendar days following
receipt of notice thereof, a report of any legal actions pending or threatened against Borrower or
any Subsidiary that could reasonably be expected to have a Material Adverse Effect (or otherwise
require the Company to report the same to the SEC); (v) within five (5) calendar days following
receipt thereof, each management letter prepared by Borrower’s independent certified public
accounting firm regarding Borrower’s management control systems; and (vi) such budgets, sales
projections, operating plans or other financial information as Bank may reasonably request from
time to time.

               (a) Within forty (40) days after the last day of each month (other than December, which shall
be thirty (30) days for drafts and seventy-five (75) days for final reporting) when the Liquidity
Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts, Borrower
shall deliver to Bank a Borrowing Base Certificate signed by a Responsible Officer in substantially
the form of Exhibit C hereto, together with aged listings by invoice due date of accounts
receivable and accounts payable.

               (b) Within forty (40) days after the last day of each month (other than December, which shall
be thirty (30) days for drafts and seventy-five (75) days for final reporting) when the Liquidity
Ratio set forth in Section 6.7(b) includes consideration of Borrower’s Eligible Accounts (or,
otherwise, forty (40) days after the end of each of Borrower’s first, second and third fiscal
quarters), Borrower shall deliver to Bank a Compliance Certificate certified as of the last day of
the applicable month and signed by a Responsible Officer in substantially the form of Exhibit
D hereto.

               (c) As soon as possible and in any event within five (5) calendar days after becoming aware of
the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible
Officer (or its designee) setting forth details of the Event of Default, and the action which
Borrower has taken or proposes to take with respect thereto.

- 15 -

 

               (d) Bank shall have a right from time to time hereafter to audit Borrower’s Accounts and
appraise Collateral at Borrower’s expense, provided that such audits will be conducted no more
often than every six (6) months unless an Event of Default has occurred and is continuing.

     Borrower may deliver to Bank on an electronic basis any certificates, reports or information
required pursuant to this Section 6.2, and Bank shall be entitled to rely on the information
contained in the electronic files, provided that Bank in good faith believes that the files were
delivered by a Responsible Officer or its designee. If Borrower delivers this information
electronically, it shall also deliver to Bank by U.S. Mail, reputable overnight courier service,
hand delivery, facsimile or .pdf file within five (5) Business Days of submission of the unsigned
electronic copy the certification of monthly financial statements, the Borrowing Base Certificate
and the Compliance Certificate, each bearing the physical signature of the Responsible Officer.

          6.3 Inventory; Returns. Borrower shall keep all Inventory in good and merchantable
condition, free from all material defects except for Inventory for which adequate reserves have
been made in accordance with GAAP. Returns and allowances, if any, as between Borrower and its
account debtors shall be on the same basis and in accordance with Borrower’s Trade Policy.
Borrower shall promptly notify Bank of all returns and recoveries and of all disputes and claims
involving more than Five Hundred Thousand Dollars ($500,000), other than in accordance with
Borrower’s Trade Policy.

          6.4 Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely
payment or deposit of all material federal, state, and local taxes, assessments, or contributions
required of it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A.,
F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory
to Bank indicating that Borrower or a Subsidiary has made such payments or deposits and any
appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a
Subsidiary need not make any payment if the amount or validity of such payment is contested in good
faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by
Borrower.

          6.5 Insurance.

               (a) Borrower, at its expense, shall keep the Collateral insured against loss or damage by
fire, theft, explosion, sprinklers, and all other hazards and risks, and in such amounts, as
ordinarily insured against by other owners in similar businesses conducted in the locations where
Borrower’s business is conducted on the date hereof. Borrower shall also maintain liability and
other insurance in amounts and of a type that are customary to businesses similar to Borrower’s.

               (b) All such policies of insurance shall be in such form, with such companies, and in such
amounts as are reasonably satisfactory to Bank. All policies of property insurance shall contain a
lender’s loss payable endorsement, in a form reasonably satisfactory to Bank, showing Bank as an
additional loss payee, and all liability insurance policies shall show the Bank as an additional
insured and shall specify that the insurer must give at least 20 days notice to Bank before
canceling its policy for any reason. Upon Bank’s request, Borrower shall deliver to Bank certified
copies of the policies of insurance and evidence of all premium payments. If no Event of Default
has occurred and is continuing, proceeds payable under any casualty policy will, at Borrower’s
option, be payable to Borrower to replace the property subject to the claim, provided that any such
replacement property shall be deemed Collateral in which Bank has been granted a first priority
security interest. If an Event of Default has occurred and is continuing, all proceeds payable
under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the
Obligations.

          6.6 Accounts. Borrower shall maintain its primary depository and operating accounts
with Bank. All material investment accounts and all other accounts maintained outside of Bank or
Bank’s Affiliates shall be subject to control agreements in form and content reasonably acceptable
to Bank. Bank agrees that it will not exercise control of such accounts unless an Event of Default
has occurred and is continuing.

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          6.7 Financial Covenants. Borrower shall at all times maintain the following financial
ratios and covenants:

               (a) Minimum Cash. A balance of Cash at Bank and Cash at Bank’s Affiliates covered by
a control agreement of not less Four Million Dollars ($4,000,000).

               (b) Minimum Liquidity Ratio. A ratio of Liquidity to all Indebtedness owing by
Borrower to Bank of at least 1.25 to 1.00. Notwithstanding the foregoing, if Borrower’s Remaining
Months’ Cash (or, “RMC”) exceeds the following amounts, the Borrowing Base portion of Borrower’s
Liquidity may not exceed the following percentages (the “Maximum Borrowing Base Component”) of
Borrower’s Liquidity, and Borrower’s Cash must be at least the respective percentages (the “Minimum
Cash Component”) of Borrower’s Liquidity:

	 	 	 	 	 	 	 	 	 
	 	 	Minimum Cash	 	Maximum Borrowing
	Remaining Months’ Cash	 	Component	 	Base Component
	< 18 months

	 	 	100	%	 	 	0	%
	18 < RMC < 24

	 	65% to 100%
	 	Up to 35%

	> 24 months

	 	40% to 100%
	 	Up to 60%

	2 consecutive quarters
of Profitability

	 	25% to 100%
	 	Up to 75%

As used herein, “Remaining Months’ Cash” means, as of any date of determination, Cash divided by
Cash Burn. If at any time Borrower’s Remaining Months’ Cash falls below any level described above,
and/or thereafter increases, the Minimum Cash and Maximum Eligible Accounts Components likewise
shall revert to the corresponding percentages described above, for so long as Borrower’s Remaining
Months’ Cash dictates such level. Notwithstanding the foregoing, if Advances exceed Fifteen
Million Dollars ($15,000,000) (the “Excess Advances”), the Minimum Cash Component of Borrower’s
Liquidity with respect to such Excess Advances shall be one hundred percent (100%) (the “Excess
Cash Component”) until such time (and only for so long) as Borrower achieves two (2) consecutive
quarters of Profitability. The Excess Cash Component shall be comprised of Cash in addition to the
Cash included in Borrower’s Liquidity with respect to Advances of up to but not exceeding Fifteen
Million Dollars ($15,000,000).

               (c) Minimum EBITDA. When Advances exceed Fifteen Million Dollars ($15,000,000), an
EBITDA, measured quarterly on a trailing six (6) months basis, of not less than the amounts, and
for the periods, set forth on Annex II hereto. Bank shall have the right to reset this EBITDA
covenant for Borrower’s fiscal years 2007, 2008 and 2009, based upon Borrower’s Board of Director’s
approved and Bank reviewed fiscal year budgets to be delivered to Bank no later than December 31 of
each year, commencing December 31, 2006. Each new Minimum EBITDA covenant shall be established, in
consultation with Borrower, within thirty (30) days of Borrower’s submission of the required
budgets; provided that, if the parties cannot agree in good faith on the revised Minimum EBITDA
covenants, Bank shall have the right to establish such covenants in its good faith business
judgment.

          6.8 Consent of Inbound Licensors. Prior to entering into or becoming bound by any
material inbound license or agreement (other than such license or agreement entered into in the
Ordinary Course of Business of Borrower), Borrower shall provide written notice to Bank of the
material terms of such license or agreement with a description of its likely impact on Borrower’s
business or financial condition.

          6.9 Creation/Acquisition of Subsidiaries. In the event Borrower or any Subsidiary
creates or acquires any Subsidiary, Borrower and such Subsidiary shall promptly notify Bank of the
creation or acquisition of such new Subsidiary and take all such action as may be reasonably
required by Bank to cause such Subsidiary to guarantee the Obligations of Borrower under the Loan
Documents and grant a continuing pledge and security

- 17 -

 

interest in and to the collateral of such Subsidiary (substantially as described on Exhibit A
hereto), and Borrower shall grant and pledge to Bank a perfected security interest in the stock,
units or other evidence of ownership of such Subsidiary.

          6.10 Further Assurances. At any time and from time to time Borrower shall execute and
deliver such further instruments and take such further action as may reasonably be requested by
Bank to effect the purposes of this Agreement.

     7. NEGATIVE COVENANTS.

          Borrower covenants and agrees that, so long as any credit hereunder shall be available and
until the outstanding Obligations are paid in full or for so long as Bank may have any commitment
to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior
written consent, which shall not be unreasonably withheld:

          7.1 Dispositions. Convey, sell, lease, license, transfer or otherwise dispose of
(collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of
its business or property, other than Permitted Transfers.

          7.2 Change in Name, Location, Executive Office, Change in Business; Change in Fiscal Year;
Change in Control. Change its name or the Borrower State or relocate its chief executive
office without thirty (30) days prior written notification to Bank; engage in any business, or
permit any of its Subsidiaries to engage in any business, other than or reasonably related or
incidental to the businesses currently engaged in by Borrower; change its fiscal year end; suffer
or permit a Change in Control.

          7.3 Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries
to merge or consolidate, with or into any other business organization (other than mergers or
consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any
of its Subsidiaries to acquire, all or substantially all of the capital stock or property of
another Person except transactions in the Ordinary Course of Business, where (i) such transactions
do not in the aggregate exceed Five Million Dollars ($5,000,000) during any fiscal year, (ii) no
Event of Default has occurred, is continuing or would exist after giving effect to such
transactions, (iii) such transactions do not result in a Change in Control, and (iv) Borrower is
the surviving entity.

          7.4 Indebtedness. Create, incur, assume, guarantee or be or remain liable with
respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness,
or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any
Indebtedness, except Indebtedness to Bank and Indebtedness incurred in the Ordinary Course of
Business (provided that no Event of Default has occurred, is continuing or would exist after
giving effect to such prepayment).

          7.5 Encumbrances. Create, incur, assume or allow any Lien with respect to any of its
property, or assign or otherwise convey any right to receive income, including the sale of any
Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens. Agree with any
Person other than Bank not to grant a security interest in, or otherwise encumber, any of its, or
covenant to any other Person that Borrower in the future will refrain from creating, incurring,
assuming or allowing any Lien with respect to any of Borrower’s property, or permit any Subsidiary
to do so; other than in connection with licenses and similar arrangements for the use of the
Intellectual Property of Borrower or its Subsidiaries in the Ordinary Course of Business.

          7.6 Distributions. Pay any dividends or make any other distribution or payment on
account of or in redemption, retirement or purchase of any capital stock, except that Borrower may
(i) repurchase the stock of former employees pursuant to stock repurchase agreements as long as an
Event of Default does not exist prior to such repurchase or would not exist after giving effect to
such repurchase, and (ii) repurchase the stock of former employees pursuant to stock repurchase
agreements by the cancellation of indebtedness owed by such former employees to Borrower regardless
of whether an Event of Default exists.

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          7.7 Investments. Directly or indirectly acquire or own, or make any material
Investment in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted
Investments, or maintain or invest any of its property with a Person other than Bank or Bank’s
Affiliates or permit any Subsidiary to do so unless such Person has entered into a control
agreement with Bank, in form and substance satisfactory to Bank, or suffer or permit any Subsidiary
to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying dividends
or otherwise distributing property to Borrower.

          7.8 Transactions with Affiliates. Directly or indirectly enter into or permit to
exist any material transaction with any Affiliate of Borrower except for transactions that are in
the Ordinary Course of Business, upon fair and reasonable terms that are no less favorable to
Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person, which
permitted transactions shall include, without limitation, reasonable and customary fees to its
directors and compensation arrangements and benefit plans for its officers and employees.

          7.9 Subordinated Debt. Make any payment in respect of any Subordinated Debt, or
permit any of its Subsidiaries to make any such payment, except in compliance with the terms of
such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any
documentation relating to the Subordinated Debt without Bank’s prior written consent.

          7.10 Inventory and Equipment. Store the Inventory or the Equipment having a book
value of One Million Dollars ($1,000,000) or more with a bailee, warehouseman, or similar third
party unless the third party has been notified of Bank’s security interest and Bank (a) has
received an acknowledgment from the third party that it is holding or will hold the Inventory or
Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable,
covering such Inventory or Equipment. Except for Inventory sold in the Ordinary Course of Business
and except for such other locations as Bank may approve in writing, Borrower shall keep the
Inventory and Equipment only at the location set forth in Section 10 and such other locations of
which Borrower gives Bank prior written notice and as to which Bank files a financing statement, or
takes other action, where needed to perfect its security interest. Notwithstanding the foregoing,
Borrower shall cause each of Integrated Commercialization Services and OSG Norwich to execute and
deliver to Bank, within sixty (60) days of the Closing Date, a bailee agreement (or similar) in
form and content reasonably acceptable to Bank.

          7.11 No Investment Company; Margin Regulation. Become or be controlled by an
“investment company,” within the meaning of the Investment Company Act of 1940, or become
principally engaged in, or undertake as one of its important activities, the business of extending
credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit
Extension for such purpose.

     8. EVENTS OF DEFAULT.

          Any one or more of the following events shall constitute an Event of Default by Borrower under
this Agreement:

          8.1 Payment Default. If Borrower fails to pay any of the Obligations within three (3)
calendar days of the date when due;

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          8.2 Covenant Default. If Borrower fails to perform any obligation under Article 6 or
violates any of the covenants contained in Article 7 of this Agreement, or fails or neglects to
perform or observe any other material term, provision, condition, covenant contained in this
Agreement, in any of the Loan Documents, or in any other present or future agreement between
Borrower and Bank and as to any default under such other term, provision, condition or covenant
that can be cured, has failed to cure such default within fifteen (15) days after Borrower receives
notice thereof or any Responsible Officer of Borrower (or Borrower’s General Counsel) becomes aware
thereof; provided, however, that if the default cannot by its nature be cured within the fifteen
(15) day period or cannot after diligent attempts by Borrower be cured within such fifteen (15) day
period, and such default is likely to be cured within a reasonable time, then Borrower shall have
an additional reasonable period (which shall not in any case exceed thirty (30) days) to attempt to
cure such default, and within such reasonable time period the failure to have cured such default
shall not be deemed an Event of Default but no Credit Extensions will be made;

          8.3 Defective Perfection. If Bank shall receive at any time following the Closing
Date an SOS Report indicating that except for Permitted Liens, Bank’s security interest in the
Collateral is not prior to all other security interests or Liens of record reflected in such SOS
Report;

          8.4 Material Adverse Effect. If there occurs any circumstance or circumstances that
could reasonably be expected to have a Material Adverse Effect;

          8.5 Attachment. If any material portion of Borrower’s assets is attached, seized,
subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any
trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or
distress warrant or levy has not been removed, discharged or rescinded within ten (10) days, or if
Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct
all or any material part of its business affairs, or if a judgment or other claim becomes a lien or
encumbrance upon any material portion of Borrower’s assets, or if a notice of lien, levy, or
assessment is filed of record with respect to any of Borrower’s assets by the United States
Government, or any department, agency, or instrumentality thereof, or by any state, county,
municipal, or governmental agency, and the same is not paid within ten (10) days after Borrower
receives notice thereof, provided that none of the foregoing shall constitute an Event of Default
where such action or event is stayed or an adequate bond has been posted pending a good faith
contest by Borrower (provided that no Credit Extensions will be made during such cure period);

          8.6 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is
commenced by Borrower, or if an Insolvency Proceeding is commenced against Borrower and is not
dismissed or stayed within thirty (30) days (provided that no Credit Extensions will be made prior
to the dismissal of such Insolvency Proceeding);

          8.7 Other Agreements. If there is a default or other failure to perform in any
agreement to which Borrower is a party with a third party or parties resulting in a right by such
third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in
an amount in excess of One Million Five Hundred Thousand Dollars ($1,500,000) or that could
reasonably be expected to have a Material Adverse Effect;

          8.8 Subordinated Debt. If Borrower makes any payment on account of Subordinated Debt,
except to the extent such payment is allowed under any subordination agreement entered into with
Bank;

          8.9 Judgments. If an uninsured judgment or uninsured judgments for the payment of
money in an amount, individually or in the aggregate, of at least Five Hundred Thousand Dollars
($500,000) shall be rendered against Borrower and shall remain unsatisfied and unstayed for a
period of fifteen (15) days (provided that no Credit Extensions will be made prior to the
satisfaction or stay of such judgment); or

          8.10 Misrepresentations. If any material misrepresentation or material misstatement
exists now or hereafter in any warranty or representation set forth herein or in any certificate
delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter
into this Agreement or any other Loan Document.

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     9. BANK’S RIGHTS AND REMEDIES.

          9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event
of Default, Bank may, at its election, without notice of its election and without demand, do any
one or more of the following, all of which are authorized by Borrower:

               (a) Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan
Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event
of Default described in Section 8.6, all Obligations shall become immediately due and payable
without any action by Bank);

               (b) Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any
Letters of Credit remaining undrawn, as collateral security for the repayment of any future
drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled
to be paid or payable over the remaining term of the Letters of Credit, and Borrower shall promptly
deposit and pay such amounts;

               (c) Cease advancing money or extending credit to or for the benefit of Borrower under this
Agreement or under any other agreement between Borrower and Bank;

               (d) Settle or adjust disputes and claims directly with account debtors for amounts, upon terms
and in whatever order that Bank reasonably considers advisable;

               (e) Make such payments and do such acts as Bank considers necessary or reasonable to protect
its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so
requires, and to make the Collateral available to Bank as Bank may designate. Borrower authorizes
Bank to enter the premises where the Collateral is located, to take and maintain possession of the
Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance,
charge, or lien which in Bank’s determination appears to be prior or superior to its security
interest and to pay all expenses incurred in connection therewith. With respect to any of
Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such
premises and to occupy the same, without charge, in order to exercise any of Bank’s rights or
remedies provided herein, at law, in equity, or otherwise;

               (f) Set off and apply to the Obligations any and all (i) balances and deposits of Borrower
held by Bank, and (ii) indebtedness at any time owing to or for the credit or the account of
Borrower held by Bank;

               (g) Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for
sale, and sell (in the manner provided for herein) the Collateral. Except to the extent Borrower
is prohibited by an enforceable license from doing so, Bank is hereby granted a license or other
right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s
labels, Intellectual Property, and advertising matter, or any property of a similar nature, as it
pertains to the Collateral, in completing production of, advertising for sale, and selling any
Collateral and, in connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s
rights under all licenses and all franchise agreements shall inure to Bank’s benefit;

               (h) Sell the Collateral at either a public or private sale, or both, by way of one or more
contracts or transactions, for cash or on terms, in such manner and at such places (including
Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the
Obligations in whatever manner or order Bank deems appropriate. Bank may sell the Collateral
without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties
of title or the like. This procedure will not be considered adversely to affect the commercial
reasonableness of any sale of the Collateral. If Bank sells any of the Collateral upon credit,
Borrower will be credited only with payments actually made by the purchaser, received by Bank, and
applied to the indebtedness of the purchaser. If the purchaser fails to pay for the Collateral,
Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale;

               (i) Bank may credit bid and purchase at any public sale;

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               (j) Apply for the appointment of a receiver, trustee, liquidator or conservator of the
Collateral, without notice and without regard to the adequacy of the security for the Obligations
and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of
the Obligations; and

               (k) Any deficiency that exists after disposition of the Collateral as provided above will be
paid immediately by Borrower.

Bank may comply with any applicable state or federal law requirements in connection with a
disposition of the Collateral and compliance will not be considered adversely to affect the
commercial reasonableness of any sale of the Collateral.

          9.2 Power of Attorney. Effective only upon the occurrence and during the continuance
of an Event of Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated
officers, or employees) as Borrower’s true and lawful attorney to: (a) send requests for
verification of Accounts or notify account debtors of Bank’s security interest in the Accounts; (b)
endorse Borrower’s name on any checks or other forms of payment or security that may come into
Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading relating to any
Account, drafts against account debtors, schedules and assignments of Accounts, verifications of
Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and
adjust all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle
and adjust disputes and claims respecting the accounts directly with account debtors, for amounts
and upon terms which Bank determines to be reasonable; and (g) to file, in its sole discretion, one
or more financing or continuation statements and amendments thereto, relative to any of the
Collateral without the signature of Borrower where permitted by law; provided Bank may exercise
such power of attorney to sign the name of Borrower on any of the documents described in clause (g)
above, regardless of whether an Event of Default has occurred. The appointment of Bank as
Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with
an interest, is irrevocable until all of the Obligations have been fully repaid and performed and
Bank’s obligation to provide Credit Extensions hereunder is terminated.

          9.3 Accounts Collection. At any time after the occurrence and during the continuance
of an Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security
interest in such funds and verify the amount of such Account. Borrower shall collect all amounts
owing to Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately
deliver such payments to Bank in their original form as received from the account debtor, with
proper endorsements for deposit.

          9.4 Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof
of payment due to third persons or entities, as required under the terms of this Agreement, then
Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of
the same or any part thereof; (b) set up such reserves under the Revolving Line as Bank deems
necessary to protect Bank from the exposure created by such failure; or (c) obtain and maintain
insurance policies of the type discussed in Section 6.5 of this Agreement, and take any action with
respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall
constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then
applicable rate hereinabove provided, and shall be secured by the Collateral. Any payments made by
Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver
by Bank of any Event of Default under this Agreement.

          9.5 Bank’s Liability for Collateral. As long as Bank complies with reasonable banking
practices, Bank has no obligation to clean up or otherwise prepare the Collateral for sale. All
risk of loss, damage or destruction of the Collateral shall be borne by Borrower, except to the
extent caused by Bank’s gross negligence or willful misconduct.

          9.6 No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the
Obligations by collecting them from any other Person liable for them and Bank may release, modify
or waive any collateral provided by any other Person to secure any of the Obligations, all without
affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to
pursue any other Person for any of the Obligations.

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          9.7 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan
Documents, and all other agreements shall be cumulative. Bank shall have all other rights and
remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise
by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of
Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute
a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a
written document signed on behalf of Bank and then shall be effective only in the specific instance
and for the specific purpose for which it was given. Borrower expressly agrees that this Section
may not be waived or modified by Bank by course of performance, conduct, estoppel or otherwise.

          9.8 Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives
demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment
and any other notices relating to the Obligations.

     10. NOTICES.

          Unless otherwise provided in this Agreement, all notices or demands by any party relating to
this Agreement or any other agreement entered into in connection herewith shall be in writing and
(except for financial statements and other informational documents which may be sent by first-class
mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery
service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower
or to Bank, as the case may be, at its addresses set forth below:

	 	 	 	 	 
	 

	 	If to Borrower:
	 	SANTARUS, INC.
	 

	 	 	 	10590 W. Ocean Air Dr., Ste 200
	 

	 	 	 	San Diego, CA 92130
	 

	 	 	 	Attn: Chief Financial Officer and Legal Affairs Department
	 

	 	 	 	FAX: (858) 314-5702
	 
	 	 	 	 
	 

	 	If to Bank:
	 	Comerica Bank
	 

	 	 	 	75 East Trimble Road, M/C 4770
	 

	 	 	 	San Jose, California 95131
	 

	 	 	 	Attn: Manager
	 

	 	 	 	FAX: (408) 556-5091
	 
	 	 	 	 
	 

	 	with a copy to:
	 	Comerica Bank
	 

	 	 	 	11943 El Camino Real, Suite 110B
	 

	 	 	 	San Diego, CA 92130
	 

	 	 	 	Attn: Steven J. Stuckey, Senior Vice President
	 

	 	 	 	FAX: (858) 509-2365

     The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other.

     11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.

     This Agreement shall be governed by, and construed in accordance with, the internal laws of
the State of California, without regard to principles of conflicts of law. Each of Borrower and
Bank hereby submits to the exclusive jurisdiction of the state and Federal courts located in the
County of San Diego, State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY
JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT
PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH
COUNSEL OF ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL
PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO
THIS AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES.

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     12. REFERENCE PROVISION.

          In the event the Jury Trial Waiver set forth above is not enforceable, the parties elect to
proceed under this Judicial Reference Provision.

          12.1 Mechanics.

               (a) With the exception of the items specified in clause (c), below, any controversy, dispute
or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any
other document, instrument or agreement between the undersigned parties (collectively in this
Section, the “Comerica Documents”), will be resolved by a reference proceeding in California in
accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure
(“CCP”), or their successor sections, which shall constitute the exclusive remedy for the
resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except
as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the
state or federal court in the county or district where the real property involved in the action, if
any, is located or in the state or federal court in the county or district where venue is otherwise
appropriate under applicable law (the “Court”).

               (b) The matters that shall not be subject to a reference are the following: (i) nonjudicial
foreclosure of any security interests in real or personal property, (ii) exercise of self-help
remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv)
temporary, provisional or ancillary remedies (including, without limitation, writs of attachment,
writs of possession, temporary restraining orders or preliminary injunctions). This reference
provision does not limit the right of any party to exercise or oppose any of the rights and
remedies described in clauses (i) and (ii) or to seek or oppose from a court of competent
jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition
to, any of those items does not waive the right of any party to a reference pursuant to this
reference provision as provided herein.

               (c) The referee shall be a retired judge or justice selected by mutual written agreement of
the parties. If the parties do not agree within ten (10) days of a written request to do so by any
party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the
Court (or his or her representative). A request for appointment of a referee may be heard on an ex
parte or expedited basis, and the parties agree that irreparable harm would result if ex parte
relief is not granted. Pursuant to CCP § 170.6, each party shall have one peremptory challenge to
the referee selected by the Presiding Judge of the Court (or his or her representative).

               (d) The parties agree that time is of the essence in conducting the reference proceedings.
Accordingly, the referee shall be requested, subject to change in the time periods specified herein
for good cause shown, to (i) set the matter for a status and trial-setting conference within
fifteen (15) days after the date of selection of the referee, (ii) if practicable, try all issues
of law or fact within one hundred twenty (120) days after the date of the conference and (iii)
report a statement of decision within twenty (20) days after the matter has been submitted for
decision.

               (e) The referee will have power to expand or limit the amount and duration of discovery. The
referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s
failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based
upon good cause shown, no party shall be entitled to “priority” in conducting discovery,
depositions may be taken by either party upon seven (7) days written notice, and all other
discovery shall be responded to within fifteen (15) days after service. All disputes relating to
discovery which cannot be resolved by the parties shall be submitted to the referee whose decision
shall be final and binding.

          12.2 Procedures. Except as expressly set forth herein, the referee shall determine
the manner in which the reference proceeding is conducted including the time and place of hearings,
the order of presentation of evidence, and all other questions that arise with respect to the
course of the reference proceeding. All proceedings and hearings conducted before the referee,
except for trial, shall be conducted without a court reporter, except that when any party so
requests, a court reporter will be used at any hearing conducted before the referee, and the
referee will be provided a courtesy copy of the transcript. The party making such a request shall
have the obligation to

- 24 -

 

arrange for and pay the court reporter. Subject to the referee’s power to award costs to the
prevailing party, the parties will equally share the cost of the referee and the court reporter at
trial.

          12.3 Application of Law. The referee shall be required to determine all issues in
accordance with existing case law and the statutory laws of the State of California. The rules of
evidence applicable to proceedings at law in the State of California will be applicable to the
reference proceeding. The referee shall be empowered to enter equitable as well as legal relief,
enter equitable orders that will be binding on the parties and rule on any motion which would be
authorized in a court proceeding, including without limitation motions for summary judgment or
summary adjudication. The referee shall issue a decision at the close of the reference proceeding
which disposes of all claims of the parties that are the subject of the reference. Pursuant to CCP
§ 644, such decision shall be entered by the Court as a judgment or an order in the same manner as
if the action had been tried by the Court and any such decision will be final, binding and
conclusive. The parties reserve the right to appeal from the final judgment or order or from any
appealable decision or order entered by the referee. The parties reserve the right to findings of
fact, conclusions of laws, a written statement of decision, and the right to move for a new trial
or a different judgment, which new trial, if granted, is also to be a reference proceeding under
this provision.

          12.4 Repeal. If the enabling legislation which provides for appointment of a referee
is repealed (and no successor statute is enacted), any dispute between the parties that would
otherwise be determined by reference procedure will be resolved and determined by arbitration.
The arbitration will be conducted by a retired judge or justice, in accordance with the California
Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with
respect to discovery set forth above shall apply to any such arbitration proceeding.

          12.5 THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED
UNDER THIS REFERENCE PROVISION WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY
KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE
PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR
IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS.

     13. GENERAL PROVISIONS.

          13.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of
the respective successors and permitted assigns of each of the parties and shall bind all Persons
who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor
any rights hereunder may be assigned by Borrower without Bank’s prior written consent, which
consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without
the consent of or notice to Borrower to sell, transfer, negotiate, or grant participation in all or
any part of, or any interest in, Bank’s obligations, rights and benefits hereunder.

          13.2 Indemnification. Borrower shall defend, indemnify and hold harmless Bank and its
officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities
claimed or asserted by any other party in connection with the transactions contemplated by this
Agreement; and (b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its
officers, employees and agents as a result of or in any way arising out of, following, or
consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise
(including without limitation reasonable attorneys’ fees and expenses), except for losses caused by
Bank’s gross negligence or willful misconduct.

          13.3 Time of Essence. Time is of the essence for the performance of all obligations
set forth in this Agreement.

          13.4 Severability of Provisions. Each provision of this Agreement shall be severable
from every other provision of this Agreement for the purpose of determining the legal
enforceability of any specific provision.

- 25 -

 

          13.5 Amendments in Writing, Integration. All amendments to or terminations of this
Agreement or the other Loan Documents must be in writing. All prior agreements, understandings,
representations, warranties, and negotiations between the parties hereto with respect to the
subject matter of this Agreement and the other Loan Documents, if any, are merged into this
Agreement and the Loan Documents.

          13.6 Counterparts. This Agreement may be executed in any number of counterparts and
by different parties on separate counterparts, each of which, when executed and delivered, shall be
deemed to be an original, and all of which, when taken together, shall constitute but one and the
same Agreement.

          13.7 Survival. All covenants, representations and warranties made in this Agreement
shall continue in full force and effect so long as any Obligations remain outstanding or Bank has
any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify
Bank with respect to the expenses, damages, losses, costs and liabilities described in Section 13.2
shall survive until all applicable statute of limitations periods with respect to actions that may
be brought against Bank have run.

          13.8 Confidentiality. In handling any confidential information, Bank and all
employees and agents of Bank shall exercise the same degree of care that Bank exercises with
respect to its own proprietary information of the same types to maintain the confidentiality of any
non-public information thereby received or received pursuant to this Agreement except that
disclosure of such information may be made (i) to the subsidiaries or Affiliates of Bank in
connection with their present or prospective business relations with Borrower, (ii) to prospective
transferees or purchasers of any interest in the Credit Extensions, provided that they have entered
into a comparable confidentiality agreement in favor of Borrower and have delivered a copy to
Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar
order, (iv) as may be required in connection with the examination, audit or similar investigation
of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder.
Confidential information hereunder shall not include information that either: (a) is in the
public domain or in the knowledge or possession of Bank when disclosed to Bank, or becomes part of
the public domain after disclosure to Bank through no fault of Bank; or (b) is disclosed to Bank by
a third party, provided Bank does not have actual knowledge that such third party is prohibited
from disclosing such information.

[Balance of Page Intentionally Left Blank]

- 26 -

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written.

	 	 	 
	 

	 	SANTARUS, INC.
	 
	 	 
	 

	 	By: /s/ Debra P. Crawford
	 

	 	 
	 
	 	 
	 

	 	Title: SVP & CFO
	 
	 	 
	 

	 	COMERICA BANK
	 
	 	 
	 

	 	By: /s/ Steven J. Stuckey
	 

	 	 
	 
	 	 
	 

	 	Title: Senior Vice President

[Signature Page to Loan and Security Agreement]

 

 

	 	 	 	 	 
	DEBTOR

	 	SANTARUS, INC.
	 	 
	 
	 	 	 	 
	SECURED PARTY:

	 	COMERICA BANK	 	 

EXHIBIT A

COLLATERAL DESCRIPTION ATTACHMENT

TO LOAN AND SECURITY AGREEMENT

     All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether
presently existing or hereafter created or acquired, and wherever located, including, but not
limited to:

          (a) all accounts (including health-care-insurance receivables), chattel paper (including
tangible and electronic chattel paper), deposit accounts, documents (including negotiable
documents), equipment (including all accessions and additions thereto), general intangibles
(including payment intangibles and software), goods (including fixtures), instruments (including
promissory notes), inventory (including all goods held for sale or lease or to be furnished under a
contract of service, and including returns and repossessions), investment property (including
securities and securities entitlements), Negotiable Collateral, letter of credit rights, money, and
all of Debtor’s books and records with respect to any of the foregoing, and the computers and
equipment containing said books and records;

          (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including,
without limitation, insurance proceeds, and all supporting obligations and the security therefor or
for any right to payment. All terms above have the meanings given to them in the California
Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9
of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45), Section
35, operative July 1, 2001.

          Notwithstanding the foregoing, the Collateral shall not include any Intellectual Property;
provided, however, that the Collateral shall include all accounts and general intangibles that
consist of rights to payment and proceeds from the sale, licensing or disposition of all or any
part, or rights in, the foregoing (the “Rights to Payment”). Notwithstanding the foregoing, if a
judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the
underlying Intellectual Property is necessary to have a security interest in the Rights to Payment,
then the Collateral shall automatically, and effective as of the Closing Date, include the
Intellectual Property to the extent and only to the extent necessary to permit perfection of Bank’s
security interest in the Rights to Payment, and further provided, however, that Bank’s enforcement
rights with respect to any security interest in the Intellectual Property shall be absolutely
limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to
the underlying Intellectual Property.

               As used herein, “Intellectual Property” means all of Borrower’s right, title, and interest in
and to the following:

               (a) Copyrights, Trademarks and Patents;

               (b) Any and all trade secrets, and any and all Intellectual Property rights in computer
software and computer software products now or hereafter existing, created, acquired or held;

               (c) Any and all design rights which may be available to Borrower now or hereafter existing,
created, acquired or held;

               (d) Any and all claims for damages by way of past, present and future infringement of any of
the rights included above, with the right, but not the obligation, to sue for and collect such
damages for said use or infringement of the Intellectual Property rights identified above;

               (e) All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all
license fees and royalties arising from such use to the extent permitted by such license or rights;

 

 

               (f) All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents;
and

               (g) All proceeds of the foregoing, including without limitation all payments under insurance
or any indemnity or warranty payable in respect of any of the foregoing.

               As used herein, “Copyrights” means any and all copyright rights, copyright applications,
copyright registrations and like protections in each work or authorship and derivative work
thereof, whether published or unpublished and whether or not the same also constitutes a trade
secret, now or hereafter existing, created, acquired or held.

               As used herein, “Patents” means all patents, patent applications and like protections
including without limitation improvements, divisions, continuations, renewals, reissues, extensions
and continuations-in-part of the same.

               As used herein, “Trademarks” means any trademark and servicemark rights, whether registered or
not, applications to register and registrations of the same and like protections, and the entire
goodwill of the business of Borrower connected with and symbolized by such trademarks.

 

 

EXHIBIT B

TECHNOLOGY & LIFE SCIENCES DIVISION

LOAN ANALYSIS

LOAN ADVANCE/PAYDOWN REQUEST FORM

DEADLINE FOR SAME DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time]

FORMULA BASED LINES: DEADLINE FOR NEXT DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time]

DEADLINE FOR EQUIPMENT ADVANCES IS [3:00 P.M., Pacific Time/ 3:30 P.M. Eastern Time ]**

DEADLINE FOR WIRE TRANSFERS IS [1:30 P.M., Pacific Time/ 3:30 P.M. Eastern Time]

[*At month end and the day before a holiday, the cut off time is 1:30 P.M., Pacific Time]

**Subject to 3 day advance notice.

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	To: Loan Analysis	 	 	  DATE:	 	 	 	TIME:	 	 	 	 	 
	 	 

	 	 	 	 	 	 	 
	 	 	 	 	 	 	 
	 	FAX #: (650) 846-6840	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	FROM:	 	SANTARUS, INC.	 	 	TELEPHONE REQUEST (For Bank Use Only):	 	 	 
	 	 

	 	Borrower’s Name	 	 	 	 	 	 	 	 	 	 	 	 
	 	FROM:	 	 	 	 	The following person is authorized to request
the loan payment transfer/loan	 	 	 
	 	 

	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	Authorized Signer’s Name	 	 	advance on the designated account and is known to me.	 	 	 
	 	FROM:
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	Authorized Signer’s Name	 	 	Authorized Request & Phone #	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	PHONE #:
	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Received by (Bank) & Phone #	 	 	 
	 	FROM ACCOUNT#:	 	 	 	 	 	 	 	 	 	 	 	 
	 	(please include Note number, if applicable)	 	 	 	 	 	 	 	 	 	 	 	 
	 	TO ACCOUNT #:	 	 	Authorized Signature (Bank)	 	 	 
	 	(please include Note number, if applicable)	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 

	 	 	 	 	 	 	 	 
	 	REQUESTED TRANSACTION TYPE

	 	REQUESTED DOLLAR AMOUNT
	 	 	For Bank Use Only	 
	 	 
	 	 	 	 	 	 
	 	PRINCIPAL INCREASE* (ADVANCE)

	 	$                                                            
	 	 	Date Rec’d:	 
	 	PRINCIPAL PAYMENT (ONLY)

	 	$                                                            
	 	 	Time:	 
	 	 

	 	 	 	 	Comp. Status:            YES                 NO	 
	 	OTHER INSTRUCTIONS:

	 	 	 	 	Status Date:	 
	 	 

	 	 	 	 	Time:	 
	 	 	 	 	 	 
	 	 

	 	 	 	 	Approval:	 
	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 

All representations and warranties (including any updates thereto pursuant to Section 3.2(b) of the
Loan Agreement) of Borrower stated in the Loan Agreement, are true, correct and complete in all
material respects as of the date of the request for and advance confirmed by this Borrowing
Certificate; provided, however, that those representations and warranties that expressly refer to
another date shall be true, correct and complete in all material respects as of such date.

*IS THERE A WIRE REQUEST TIED TO THIS LOAN ADVANCE? (PLEASE CIRCLE ONE                     YES           NO

          If YES, the Outgoing Wire Transfer Instructions must be completed below.

	 	 	 	 	 
	OUTGOING WIRE TRANSFER INSTRUCTIONS

	 	Fed Reference Number
	 	Bank Transfer Number

The items marked with an asterisk (*) are required to be completed.

	 	 	 	 
	 	 	 	 
	*Beneficiary Name
	 	 	 
	 	 	 	 
	*Beneficiary Account Number
	 	 	 
	 	 	 	 
	*Beneficiary Address
	 	 	 
	 	 	 	 
	Currency Type

	 	 	US DOLLARS ONLY
	 	 	 	 
	*ABA Routing Number (9 Digits)
	 	 	 
	 	 	 	 
	*Receiving Institution Name
	 	 	 
	 	 	 	 
	*Receiving Institution Address
	 	 	 
	 	 	 	 
	*Wire Account

	 	 	$

 

 

EXHIBIT C

BORROWING BASE CERTIFICATE

	 	 	 	 	 	 	 
	 
	 
	 	 	 	 	 	 
	Borrower: SANTARUS, INC.	 	Lender: Comerica Bank
	 
	 	 	 	 	 	 
	Commitment Amount: $20,000,000	 	 	 	 
	 
	 	 	 	 	 	 
	 
	ACCOUNTS RECEIVABLE	 	 	 	 
	1.

	 	Accounts Receivable Book Value as of ___
	 	 	 	$                                        
	2.

	 	Additions (please explain on reverse)
	 	 	 	$                                        
	3.

	 	TOTAL ACCOUNTS RECEIVABLE
	 	 	 	$                                        
	 
	 	 	 	 	 	 
	ACCOUNTS RECEIVABLE DEDUCTIONS (without duplication)	 	 	 	 
	4.

	 	Amounts over 60 days past due
	 	$                                        	 	 
	5.

	 	Balance of 25% over 60 day past due accounts
	 	$                                        	 	 
	6.

	 	Concentration Limits	 	 	 	 
	7.

	 	Foreign Accounts (other than Eligible Foreign Accounts)
	 	$                                        	 	 
	8.

	 	Governmental Accounts
	 	$                                        	 	 
	9.

	 	Contra Accounts
	 	$                                        	 	 
	10.

	 	Demo Accounts
	 	$                                        	 	 
	11.

	 	Intercompany/Employee Accounts
	 	$                                        	 	 
	12.

	 	Other (please explain on reverse)
	 	$                                        	 	 
	13.

	 	TOTAL ACCOUNTS RECEIVABLE DEDUCTIONS
	 	 	 	$                                        
	14.

	 	Eligible Accounts (#3 minus #13)
	 	 	 	$                                        
	15.

	 	LOAN VALUE OF ACCOUNTS (80% of #14)
	 	 	 	$                                        

The undersigned represents and warrants that the foregoing is true, complete and correct, and that
the information reflected in this Borrowing Base Certificate complies with the representations and
warranties set forth in the Loan and Security Agreement (including any updates thereto pursuant to
Section 3.2(b) of the Loan Agreement) between the undersigned and Comerica Bank.

	 	 	 	 	 
	SANTARUS, INC.	 	 
	 
	 	 	 	 
	By:
	 	 	 	 
	 	 	 	 	 
	 

	 	     Authorized Signer	 	 

 

 

EXHIBIT D

COMPLIANCE CERTIFICATE

	 	 	 
	TO:

	 	COMERICA BANK
	 
	 	 
	FROM:

	 	SANTARUS, INC.

          The undersigned authorized officer of SANTARUS, INC. hereby certifies that in accordance with
the terms and conditions of the Loan and Security Agreement between Borrower and Bank (the
“Agreement”), (i) Borrower is in complete compliance for the period ending                                          with all
required covenants except as noted below and (ii) all representations and warranties (including any
updates thereto pursuant to Section 3.2(b) of the Loan Agreement) of Borrower stated in the
Agreement, as amended from time to time, are true and correct as of the date hereof; provided,
however, that those representations and warranties that expressly refer to another date shall be
true and correct in all material respects as of such date. Attached herewith are the required
documents supporting the above certification. The Officer further certifies that these are
prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently
applied from one period to the next except as explained in an accompanying letter or footnotes.

Please indicate compliance status by circling Yes/No under “Complies” column.

	 	 	 	 	 	 	 	 	 
	Reporting Covenant	 	Required	 	 	 	Complies	 	 
	 
	Monthly financial statements

	 	Monthly within 40 days;
except for December: 30 days
for drafts; 75 days for final
(when Liquidity includes
Eligible Accounts)
	 	Yes
	 	No
	 	N/A
	Quarterly financial statements (other than 4th quarter)

	 	Quarterly within 40 days
(when Liquidity does not
include Eligible Accounts)
	 	Yes
	 	No
	 	N/A
	Annual (CPA Audited)

	 	FYE within 120 days
	 	Yes
	 	No
	 	N/A
	10K and 10Q

	 	When filed
	 	Yes
	 	No
	 	N/A
	A/R & A/P Agings, Borrowing Base Cert.

	 	Monthly within 40 days
(waived when Liquidity does
not include the Borrowing
Base)
	 	Yes
	 	No
	 	N/A
	Compliance Cert.

	 	Monthly within 40 days;
except for December: 30 days
for drafts; 75 days for final
(when Liquidity includes
Eligible Accounts); otherwise
quarterly within 40 days
	 	Yes
	 	No	 	 
	A/R Audit

	 	Initial and Semi-Annual	 	 	 	 	 	 
	Total amount of Borrower’s cash and investments

	 	Amount: $                    	 	 	 	 	 	 
	Total amount of Borrower’s cash and investments maintained with Bank
and Bank’s Affiliates

	 	Amount: $4,000,000
	 	Yes
	 	No	 	 

	 	 	 	 	 	 	 	 	 	 	 
	Financial Covenant	 	Required	 	Actual	 	 	 	Complies	 
	 
	Maintain at all times, measured Monthly (except as indicated):
	 	 	 	 	 	 	 	 	 	 
	Minimum Cash
	 	$4,000,000	 	$                    	 	Yes	 	No
	Minimum Liquidity (please explain below)1
	 	1.25:1.00	 	_______:1.00	 	Yes	 	No
	Minimum EBITDA (when Advances > $15MM)
	 	2	 	$                    	 	Yes	 	No

 

			
	1	 	See Section 6.7(b) and explain on attachment RMC and Minimum Cash Component and Maximum Eligible Accounts Component
	 
	2	 	measured quarterly on a trailing 6-month basis, as set forth in Annex II hereto; to be reset for each of fiscal
years 2007, 2008 and 2009 based on Borrower’s Board of Director’s approved budget for each year, to be delivered to Bank no later
than 12/31 of each year.

Comments Regarding Exceptions: See Attached.

Sincerely,

 

 

 

 

 

SIGNATURE

 

TITLE

 

DATE

	 	 	 	 	 	 	 
	BANK USE ONLY	 	 
	 
	 	 	 	 	 	 
	Received by:	 	 	 	 
	 	 	 	 	 	 	 
	 

	 	 	 	AUTHORIZED SIGNER	 	 
	 
	 	 	 	 	 	 
	Date:
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	Verified:
	 	 	 	 	 	 
	 	 	 	 	 
	 

	 	 	 	AUTHORIZED SIGNER
	 	 
	 
	 	 	 	 	 	 
	Date:
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	Compliance Status	Yes          No

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