Document:

Severance Agreement

 Exhibit 10.19 
  
 SEVERANCE AGREEMENT AND FULL WAIVER AND RELEASE 
  
 This SEVERANCE AGREEMENT AND FULL WAIVER AND RELEASE (“Agreement”) sets forth the agreement reached between
FREDERICK JACOBS (“Employee”) and APHTON CORPORATION (“Company”). 
  
 1. Employment Termination. Employee’s last day of work was June 30, 2005 (the “Termination Date”). Employee represents
that he has returned all keys, passes, credit cards and other property of the Company, including all documents, computer discs, tapes and other materials that relate to the business of the Company, and will otherwise has complied with the normal
employment termination procedures of the Company. 
  
 2.
Consideration to Employee. A. In consideration for the promises set forth in this Agreement and Employee’s execution of this Agreement, but subject to Paragraph 8 of this Agreement entitled Review and Revocation Period, Company shall pay
to Employee a severance amount equal to $110,769.24 (less deductions, withholdings, and other payments required under applicable law) within fifteen (15) days of the Effective Date (as defined in Paragraph 8). Employee agrees that this is
adequate consideration for the promises he is making in this Agreement and the rights and claims he is waiving and releasing under this Agreement. 
  
 B. As additional consideration, the Company agrees that notwithstanding the terms of any individual agreement, the vesting period of all stock options
held by the Employee on the Effective Date which remain unvested shall be accelerated such that all such unvested stock options shall be fully vested as of the Effective Date. In addition, the Company agrees that notwithstanding any early
termination provisions set forth in any option grant letter or option award agreement issued to Employee by the Company, all stock options held by Employee on the Effective Date shall remain exercisable until the scheduled expiration of the stock
options, as provided in such letters or agreements, as the case may be. 
  

			
	  

 Employee
	 	  

 Company                

  
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 3. Consideration to the Company. In consideration for the promises set forth in this Agreement:

  
 A. General Release 
  
 (1) Waiver and Release. Employee voluntarily and knowingly agrees
that he, on behalf of himself and his representatives, agents, heirs, and assigns, waives and releases and forever discharges the Company, including its parent and subsidiary corporations, affiliates, all related domestic and foreign businesses,
entities, corporations, and partnerships, as well as all current and former directors, officers, executives, shareholders, partners, employees, successors in interest, predecessors, representatives, agents, insurers, and assigns from any and all
claims, rights, and causes of action, in law or in equity, of any kind whatsoever, including, but not limited to, claims arising under Title VII of the Civil Rights Act, the Americans With Disabilities Act, the Older Workers Benefit Protection Act,
and the Age Discrimination in Employment Act, which Employee has or may have against the Company from the beginning of the world until the Effective Date, whether such claims, rights, or causes of action are now known or are later discovered.
Employee declares and represents that he has not suffered any on-the-job injuries or work-related accidents or injuries, occupational diseases or disabilities, whether temporary, permanent, partial, or total. 
  
 (2) Covenant Not to Sue. Employee voluntarily and knowingly
agrees that he, on behalf of himself and his spouse, representatives, agents, heirs, and assigns, promises never to file a lawsuit or assist in or commence any action asserting any claims, rights, liabilities, damages, losses, demands, obligations,
and causes of action, in law or in equity, of any kind whatsoever, which have been released hereunder. 
  
 (3) Known or Unknown Claims. The parties understand and expressly agree that this Agreement extends to all claims of every nature and kind,
known or unknown, or suspected or unsuspected, past, present, or future, arising from or attributable to any conduct of the Company and its successors, subsidiaries, and affiliates, and all their current, former, and future directors, officers,
executives, shareholders, partners, employees, successors in interest, predecessors, representatives, agents, insurers, attorneys, and assigns, whether known by Employee or whether or not Employee believes he may have any claims. 
  
 (4) Exceptions from Release. Notwithstanding the generality of the
foregoing, Employee does not release the following claims: 
  
 (a) Claims to continued participation in certain of the Company’s group benefit plans pursuant to the terms and conditions of the federal law known as COBRA; 
  

			
	  

 Employee
	 	  

 Company                

  
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 (b) Claims to any benefit entitlements vested as of the Termination Date, pursuant to written terms of
any Company employee benefit plan; and 
  
 (c) Claims to
indemnity for his actions as an employee of the Company, to the extent permitted by the Company’s by-laws and by Pennsylvania law. 
  
 B. Confidential Information, Non-Competition and Non-Solicitation of the Company. 
  
 (1) Agreement Not to Disclose Confidential Information. Employee acknowledges he has read and understands the
Company’s Statement of Policy Regarding Confidential Information (“Confidentiality Policy”), which is attached hereto as Exhibit “A” and incorporated herein by reference, and acknowledges and agrees that he has
been and will continue to be bound by, and will comply with, the Confidentiality Policy at all times on and subsequent to the Termination Date. Employee further agrees at all times on and subsequent to the Termination Date to hold the terms and
conditions of this Agreement in trust and confidence, and will not use any Confidential Information (as defined in the Confidentialtiy Policy) for any purpose, or disclose any such Confidential Information to any third party, unless authorized to do
so in writing by the Chief Executive Officer of the Company. In addition, Employee shall keep the terms of this Agreement in trust and confidence. 
  
 (2) Agreement to Comply with Company Policy Regarding Inventions and Ideas. Employee acknowledges he has read and understands the Company’s
Policy Regarding Inventions and Ideas (“Inventions Policy”), which is attached hereto as Exhibit “B” and incorporated herein by reference. Employee acknowledges and agrees that at all times on and subsequent to the
Termination Date, he has been and will continue to be bound by, and will comply with, the Inventions Policy. 
  
 (3) Agreement Not to Compete. Employee agrees that for a period of two (2) years following the Termination Date (the “Non-Compete
Period”), Employee will not directly or indirectly (on his own behalf or on behalf of any other person or entity) engage in any business (or own an interest in an individual proprietorship, partnership, corporation, joint venture, trust or

  

			
	  

 Employee
	 	  

 Company                

  
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 other form of business entity, whether as an individual proprietor, partner, shareholder, joint venturer, officer,
director, broker, employee, sales person, trustee, independent contractor, or in any manner whatsoever (except for a passive ownership interest not exceeding five percent (5%) of a publicly traded entity), that is of the type and character or
that is competitive with any business conducted by the Company at any time during Employee’s employment. The parties hereby agree that the Company was engaged during Employee’s employment with the Company in the business of developing
products using immunotherapy technology for neutralizing hormones that participate in gastrointestinal system and reproductive system cancer and non-cancer diseases and is also engaged in the business of research and development in the area of
biotechnology, including but not limited to, hybridoma, monoclonal antibodies, and recombinant DNA (the “Business”). 
  
 (4) Agreement Not to Recruit the Company’s Employees or Consultants. Employee agrees that both during the Engagement Period and for a period
of two (2) years following expiration or termination, as the case may be, of the Engagement Period for any reason (the “Non-Solicit Period”), Employee will not directly or indirectly (on his own behalf or on behalf of any other
person or entity) recruit, solicit or otherwise induce any employee or consultant of the Company, or any individual or entity that had been employed or engaged as a consultant by the Company within one (1) year prior to the Termination Date to
enter into an employment or a consulting relationship with any other business entity that competes with the Business. 
  
 (5) Agreement Not to Solicit the Company’s Clients/Customers. Employee agrees that until the end of the Non-Solicit Period, Employee will not
directly or indirectly (on his own behalf or on behalf of any other person or entity), solicit any business similar to the Business from any clients, customers or strategic partners of the Company, or divert or attempt to divert from the Company any
business relationship which existed between the Company and any such clients, customers or strategic partners. 
  
 (6) Reasonableness of this Section 3. Employee agrees that the provisions of this Section 3 are reasonable and necessary for the
protection of the Company’s Confidential Information; its clients’, customers’ and strategic partners’ confidential information; its business relationships with its clients, customers and strategic partners; and its undisrupted
workplace. 
  

			
	  

 Employee
	 	  

 Company                

  
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 (7) Notice to New Employer. Employee agrees that, prior to the commencement of any new employment
or consultation with a person or entity in any business which is or may be similar to the Business, he will advise the person or entity of the terms of this Section 3. The Employee also agrees that the Company may advise any new or prospective
employer of the existence and terms of this Agreement and may furnish said employer or Employee with a copy of the relevant provisions of this Agreement. 
  
 (8) Absence of Geographic Description; Savings Clause. Employee acknowledges that there are no geographic restrictions contained in this
Section 3.B. because the Business is international and not limited to any one geographic area. Notwithstanding, if a court of competent jurisdiction finds any or all of the foregoing paragraphs invalid for lack of a specific geographic
restriction, Employee agrees that the applicable geographical restriction is the United States. 
  
 (9) Remedies for Breaches of Section 3.B. In the event of a breach or potential breach of this Section 3.B., Employee acknowledges that
the Company and its affiliates will be caused irreparable injury and that money damages may not be an adequate remedy and agree that the Company and its affiliates shall be entitled to injunctive relief (in addition to its other remedies at law) to
have the provisions of this Section 3 enforced. It is hereby acknowledged that the provisions of this Section 3.B. are for the benefit of the Company and all of the affiliates of the Company and each such entity may enforce the provisions
of this Section 3.B. and only the applicable entity can waive the rights hereunder with respect to its confidential information and Employees. 
  
 C. Consequences of Breach. Employee agrees that if he files or asserts any claims, including any charges of discrimination/retaliation with any
administrative agency or any complaint in any court, waived or released by this Agreement, Employee shall be deemed to be in breach of this Agreement, and the Company shall be entitled to immediate dismissal with prejudice of any such claim.

  

			
	  

 Employee
	 	  

 Company                

  
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 4. Assignability. If the Company or any entity resulting from any merger or consolidation with the
Company is acquired by, or merged or consolidated into or with any other entity or entities, or if substantially all of the assets of the Company or any such entity are sold or otherwise transferred to another entity, the provisions of this
Agreement shall be binding upon and shall inure to the benefit of the continuing entity in or the entity resulting from such acquisition, merger or consolidation or the entity to which such assets are sold or transferred. This Agreement shall not be
assignable by the Employee. 
  
 5. Amendments to Agreement.
Any amendments, additions, or supplements to this Agreement shall be effective and binding on the parties only if any such amendments, additions, or supplements are in writing and signed by both parties. 
  
 6. Severability and Governing Law. If any provision (other than the
waiver and release) of this Agreement is invalid, illegal or unenforceable, it shall not affect the other provisions of this Agreement, which shall remain in effect. This Agreement shall be governed by the laws of the Commonwealth of Pennsylvania,
without reference to its choice of law rules, and venue of any action brought under this Agreement shall be exclusively in Philadelphia, Pennsylvania. Any proceeding under this Agreement shall be heard by a judge without a jury. 
  
 7. Survivability. All Paragraphs of Section 3.B. of this
Agreement survive the termination and/or expiration of this Agreement. 
  
 8. Review and Revocation Period. Employee has had a reasonable period of time of up to twenty-one (21) days after the date this Agreement was delivered to him to decide whether to sign this Agreement. Employee understands that
he can use all or any part of this 21-day period to decide whether to sign this Agreement. 
  
 A. Employee and the Company agree that any material or non-material changes which may be made in this Agreement after the Agreement is initially provided to Employee shall not re-start the running of the 21-day
period. Employee acknowledges that he has been encouraged to consult with an attorney prior to signing this Agreement. 
  
 B. For a period of seven (7) days following the date Employee signs this Agreement (the “Revocation Period”), Employee may revoke
this Agreement by providing written notice of revocation to Patrick T. Mooney, M.D., Chief Executive Officer, Aphton Corporation, 8 Penn Center, Suite 2300, 1628 JFK Boulevard, Philadelphia, PA 19103, to be received not later than 5:00 p.m. on the
seventh (7th) day of the Revocation Period. 
  

			
	  

 Employee
	 	  

 Company                

  
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 C. This Agreement shall become effective and enforceable upon expiration of the Revocation Period unless
this Agreement is timely revoked by Employee. The “Effective Date” of this Agreement shall be the eighth day following the signing of this Agreement by Employee, so long as the Employee has not revoked the Agreement. 
  
 9. Non-Admission; No Disparagement. Nothing in this Agreement shall be
construed as an admission or concession of any liability, unlawful conduct, or wrongdoing whatsoever by either party. Employee agrees not to make any disparaging comments about the Company. 
  
 10. No Third Party Beneficiaries. There are no third beneficiaries to
this Agreement. 
  
 11. Entire Agreement. This Agreement
contains the entire understanding of the parties in respect of its subject matter and supersedes all prior agreements and understandings (oral or written) between or among the parties with respect to such subject matter. 
  
 BOTH PARTIES, HAVING HAD A FULL OPPORTUNITY TO REVIEW THE FOREGOING, AND BOTH PARTIES, BEING
IN COMPLETE AND FULL AGREEMENT AS TO THE TERMS OF THIS AGREEMENT, HAVE VOLUNTARILY SIGNED THIS AGREEMENT. 
  

			
	  

 Employee
	 	  

 Company                

  
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	 APHTON CORPORATION
  
 /s/ Patrick Mooney

 Patrick Mooney, in his capacity as Chief
 Executive Officer (CEO) and as authorized
 representative of Company
	 	 FREDERICK JACOBS
  
 /s/ Frederick Jacobs

  

		
	 Date: July 22, 2005
  
 Witness:
	 	 Date: July 22, 2005
  
 Witness:

  

			
	  

 Employee
	 	  

 Company                

  
 Page 8 of 8Employment Agreement

 Exhibit 10.20 
  
 EMPLOYMENT AGREEMENT 
  
 EMPLOYMENT AGREEMENT, effective as of May 10, 2005 (the “Commencement Date”) by and between Aphton Corporation, a Delaware
corporation and its successors or assigns (the “Company”), and Manfred Ruediger (“Executive”). 
  
 W I T N E S S E T H: 
  
 WHEREAS, the Board of Directors of the Company (the “Board”) desires to employ Executive on the terms and conditions of this Agreement,
and Executive desires to be employed by the Company on the terms and conditions of this Agreement. 
  
 NOW, THEREFORE, in consideration of the promises and mutual covenants contained herein and for other good and valuable consideration, the parties agree as
follows: 
  
 1. Positions. 
  
 (a) Executive shall serve as the Chief Operating Officer of
the Company. 
  
 (b) Executive shall have such
duties and authority, consistent with the position of chief operating officer of a company as shall be assigned to him from time to time by the Chief Executive Officer. Executive shall report directly to the Chief Executive Officer in performing his
duties hereunder. 
  
 (c) The Executive is an at
will employee of the Company. Accordingly, the Company may terminate Executive at any time for any lawful reason. During his term of employment (“Employment Term”), Executive shall devote all of his business time and efforts to the
performance of his duties hereunder; provided, however, that Executive shall be allowed, to the extent that such activities do not materially interfere with the performance of his duties and responsibilities hereunder, to manage his
passive personal interests and, subject to the next sentence, to serve on the board of directors, or on committees of such board of directors (or any similar positions), of any for-profit, charitable or civic entity. Executive may serve on such
boards of directors or committees only with prior written approval by the Board (which approval may be withdrawn for any good reason, as determined by the Board in its sole discretion) and Executive shall not serve on any board of directors if such
service would be inconsistent with his fiduciary responsibilities to the Company. 
  
 2. Base Salary. During the Employment Term, the Company shall pay Executive a base salary at the annual rate of not less than $174,200 (“Base Salary”). Base Salary shall be payable in
accordance with the usual payroll practices of the Company, but no less frequently than monthly. Executive’s Base Salary shall be reviewed annually in December by the Compensation Committee of the Company’s Board (the “Compensation
Committee”) during the period of the Employment Term and may be increased, but not decreased, from time to time by the Compensation Committee and shall constitute “Base Salary” for purposes of this Agreement. 
  

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 3. Incentive Compensation. 
  
 (a) Annual Bonus. For each fiscal year after the Commencement Date and during the Employment
Term, the Compensation Committee may award the Executive a bonus (the “Bonus”) in accordance with performance targets, measurements and such other criteria as shall be established for such year by the Compensation Committee on or
before March 31st of such year. The Bonus shall be earned and deemed accrued on the date the Compensation
Committee approves the award of the Bonus. If awarded, the Bonus shall be paid by March 31st of the calendar
year immediately following the calendar year for which the Bonus was awarded. 
  
 (b) Stock Options. Upon the Commencement Date, Executive will be granted options to purchase one hundred and fifty thousand (150,000) shares of the Company’s common stock subject to the terms
set forth in the Option Agreement between the Company and Executive dated as of the same date (the “Option Agreement”). Executive shall be entitled to receive additional stock options and such other long term compensation as may be
determined by the Compensation Committee from time to time in its discretion. 
  
 4. Employee Benefits. During the Employment Term, Executive shall be entitled to participate in all insurance, pension, long-term incentive compensation, retirement, savings, welfare and other employee benefit
plans and arrangements, fringe benefits and perquisites generally provided by the Company from time to time for the benefit of comparable senior executive officers (collectively, “Additional Benefits”); provided,
however, that in the event Executive receives such benefits under any other contract between the Company and/or any subsidiary or affiliate of the Company and Executive or under any statutory or legal requirement, such benefits shall be in
lieu of the Additional Benefits. Nothing in this Agreement requires the Company to maintain any welfare or health plan in existence at the time this Agreement is executed or to create or obtain any new welfare or health plan. 
  
 5. Business Expenses. The Company shall reimburse Executive for the
travel, entertainment and other business expenses incurred by Executive in the performance of his duties hereunder, including, without limitation, the cost of conferences, seminars and other educational classes or meetings attended by Executive, in
accordance with the Company’s policies as in effect from time to time. 
  
 6. Change in Control. (a) If Executive’s employment is terminated due to either a Termination Without Cause (as defined below) or Termination For Good Reason (as defined below) and such termination
occurs within thirteen (13) months after a Change in Control (as defined below), Executive shall receive a cash lump sum within five (5) days of the date of termination (the “Termination Date”) in an amount equal to:
(i) (A) if the Change in Control occurred prior to the accrual of a Bonus to the Executive for fiscal year 2005, two (2) times the then current Base Salary or (B) if the Change in Control occurred after the accrual of a Bonus to
the Executive for fiscal year 2005, one and one-half (1.5) times the sum of the then current Base Salary plus the mean Bonus paid with respect to the prior three fiscal years plus (ii) the sum of any accrued amounts and accrued benefits
due and owing by the Company on the Termination Date. In addition, if applicable, the Company, at its option, will (i) permit Executive to 
  

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 participate in the Additional Benefits, in accordance with their respective terms and conditions, for a period of
twenty-four (24) months following the Termination Date or (ii) pay the cash equivalent of the Additional Benefits in a cash lump sum within thirty (30) days after the Termination Date. 
  
 (i) Termination Without Cause. A Termination Without Cause shall be
deemed to occur if the Company terminates Executive’s employment for any reason other than for death, disability or for Cause (as defined below). For purposes of this Agreement, the term “Cause” shall be limited to the following:

  
 (A) Executive’s willful refusal or
willful failure to perform his duties; 
  
 (B)
Executive’s willful misconduct or gross negligence with regard to the Company or its affiliates or their business, assets or employees (including, without limitation, Executive’s fraud, embezzlement or other act of dishonesty with regard
to the Company or its affiliates); 
  
 (C)
Executive’s willful misconduct or omission which has a material adverse economic impact on the Company or its affiliates; 
  
 (D) Executive’s conviction of, or pleading nolo contendere to, any felony or any crime involving fraud, dishonesty or moral
turpitude; 
  
 (E) Executive’s willful
refusal or willful failure to follow the lawful written direction of the Board; 
  
 (F) Executive’s breach of a fiduciary duty owed to the Company or its affiliates, including, but not limited to, those set forth in
Section 7 hereof; or 
  
 (G) any other
breach by Executive of this Agreement that remains uncured for ten (10) days after written notice thereof is given to Executive. 
  
 (ii) Termination for Good Reason. A Termination For Good Reason shall be deemed to occur if Executive terminates his employment for Good
Reason (as defined below) at any time after providing Company thirty (30) days written notice. For purposes of this Agreement, “Good Reason” shall mean the occurrence, without Executive’s express written consent in the case of
(A), (B), (C) or (D), of any of the following circumstances: 
  
 (A) A material reduction in Executive’s title or responsibilities as set forth in Section 1, including, without limitation, the requirement to report to any person other than the Chief Executive Officer, the
Board or a committee of the Board; 
  
 (B) Any
reduction in Executive’s Base Salary; 
  

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 (C) A material diminution in the Executive’s eligibility to participate in bonus,
stock options, incentive awards and other compensation plans or a diminution in Executive benefits; 
  
 (D) A change in the location of the Executive’s principal place of employment by the Company of more than fifty (50) miles from
the location at which he was principally employed immediately prior to such change; provided, however, that a requirement that Executive spend up to ten (10) business days each calendar month for the fulfillment of his obligations
hereunder in Philadelphia, Pennsylvania shall not be deemed a change in location; or 
  
 (E) A material breach or violation by the Company of any provision of this Agreement, including, without limitation, non-payment of any
material amounts owed by the Company when due. 
  
 (iii)
Change in Control. For purposes of this Agreement, the term “Change in Control” shall mean the occurrence of any of the following: 
  
 (A) any “person” as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the
“Act”) (other than the Company, any trustee or other fiduciary holding securities under any employee benefit plan of the Company, or any company owned, directly or indirectly, by the stockholders of the Company in substantially the
same proportions as their ownership of Common Stock of the Company), becomes the “beneficial owner” (as defined in Rule 13d-3 under the Act), directly or indirectly, of securities of the Company representing twenty-five percent
(25%) or more of the combined voting power of the Company’s then outstanding securities; 
  
 (B) during any period of two (2) consecutive years, individuals who at the beginning of such period constitute the Board, and any
new director (other than a director designated by a person who has entered into an agreement with the Company to effect a transaction described in clause (A), (C), or (D) of this paragraph) whose election by the Board or nomination for election
by the Company’s stockholders was approved by a vote of at least two-thirds of the directors then still in office who either were directors at the beginning of the two-year period or whose election or nomination for election was previously so
approved, cease for any reason to constitute at least a majority of the Board; 
  
 (C) a merger or consolidation of the Company with any other corporation, other than a merger or consolidation which would result in the
voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity) more than fifty percent (50%) of the combined
voting power of the voting securities of the Company or such surviving entity outstanding immediately after such merger or consolidation; or 
  

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 (D) the stockholders of the Company approve a plan of complete liquidation of the
Company or the consummation of the sale or disposition by the Company of all or substantially all of the Company’s assets other than (x) the sale or disposition of all or substantially all of the assets of the Company to a person or
persons who beneficially own, directly or indirectly, at least fifty percent (50%) or more of the combined voting power of the outstanding voting securities of the Company at the time of the sale or (y) pursuant to a spin-off type
transaction, directly or indirectly, of such assets to the stockholders of the Company. 
  
 (b) Vesting of Stock Options. If Executive’s employment is terminated due to either a Termination Without Cause or Termination For Good Reason and such termination occurs within thirteen (13) months
after a Change in Control, (i) each non-qualified stock option granted the Executive shall be immediately vested and exercisable for a period ending the earlier of 180 days after the termination date or the scheduled expiration date of such
option, (ii) each incentive stock option (“ISO”) granted to Executive shall be immediately vested and exercisable in accordance with the terms of the applicable ISO agreement and (iii) any restricted shares granted to Executive
shall become vested and shall be delivered to Executive free and clear of any restrictions, other than pursuant to applicable securities laws. 
  
 (c) No Mitigation; No Set-Off. In the event of any termination of employment under Section 6, Executive shall be under no obligation to
seek other employment and there shall be no offset against any amounts due Executive under this Agreement on account of any remuneration attributable to any subsequent employment that Executive may obtain. Any amounts due under Section 6 are in
the nature of severance payments and are not in the nature of a penalty. The amounts due under Section 6 hereof, are inclusive of, and in lieu of, any amounts payable under any (i) other contract between the Company and/or any
subsidiary or affiliate of the Company and the Executive, (ii) statutory payments or other amounts due to law, or (iii) other salary continuation or cash severance arrangement of the Company and/or any subsidiary, and to the extent paid or
provided under any other such arrangement shall be offset from the amount due hereunder. 
  
 (d) Release. Executive agrees that, as a condition to receiving the payments and benefits provided under Section 6 hereunder he will execute, deliver and not revoke (within the time period permitted by
applicable law) a release of all claims of any kind whatsoever against the Company, its affiliates, officers, directors, employees, agents and stockholders in the standard form then being used by the Company for senior executive officers (but
without release of the right of indemnification hereunder or under the Company’s By-laws or rights under benefit or equity plans that by their terms are intended to survive termination of his employment). 
  
 (e) Termination of Other Positions. Upon any termination of
employment, Executive hereby resigns as an officer and director of the Company, any subsidiary and any affiliate and as a fiduciary of any benefit plan of any of the foregoing. Executive shall promptly execute any further documentation thereof as
requested by the Company and, if the Executive is to receive any payments from the Company and/or any subsidiary or affiliate, execution of such further documentation shall be a condition thereof. 
  

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 7. Confidential Information, Non-Competition and Non-Solicitation of the Company. 
  
 (a) Agreement Not to Disclose Confidential Information.
(i) Executive acknowledges he has read and understands the Company’s Statement of Policy Regarding Confidential Information (“Confidentiality Policy”) and that the Confidentiality Policy is incorporated by reference as
part of this Agreement. Executive agrees to hold confidential or proprietary information and trade secrets (“Confidential Information,” as that term is defined by the Confidentiality Policy) in trust and confidence. Executive agrees
and acknowledges that for purposes of this Section 7, any references to the Company shall include all subsidiaries and affiliates of the Company and Confidential Information shall include any and all information owned or used by a Company
subsidiary or affiliate to the same extent as if it was owned by the Company. In this regard, Executive agrees that during and subsequent to Executive’s employment with the Company, Executive agrees that he will abide by the Confidentiality
Policy. Executive shall use Confidential Information only for the contemplated purposes for the sole benefit of the Company; shall not use Confidential Information for any other purpose; and shall not disclose or cause to be disclosed Confidential
Information to any employee, consultant, or third party, except as required in the course and scope of Executive’s employment by the Company and only if the employee, consultant, or third party has executed an Agreement Not to Disclose
Confidential Information. Executive further acknowledges that the Confidentiality Policy may be amended from time to time, and Executive agrees that this paragraph survives and applies to all such amendments. 
  
 (ii) The parties agree that the failure of any Confidential
Information to be marked or otherwise labeled as confidential or proprietary information shall not affect its status as Confidential Information. 
  
 (iii) Executive agrees that all Confidential Information and other materials relating in any way to any Confidential Information shall be
and remain the Company’s sole property during and after Executive’s employment. 
  
 (iv) Executive agrees that he will not duplicate any Confidential Information or other materials relating in any way to any Confidential
Information, other than as necessary to fulfill his obligations as an officer of the Company, without the express written consent of the Company. 
  
 (v) Executive agrees to take all reasonable steps needed or requested by the Company to ensure that all Confidential Information is kept
confidential. 
  
 (vi) Executive agrees that upon
demand by the Company, he will return all Confidential Information, including any notes, to the Company and will represent to the Company in writing at such time that he has complied with the provisions of this subparagraph. 
  

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 (b) Agreement to Comply with Company Policy Regarding Inventions and Ideas. Executive acknowledges
he has read and understands the Company’s Policy Regarding Inventions and Ideas (“Inventions Policy”) and that the Inventions Policy is incorporated by reference into this Agreement. Executive agrees that during and subsequent
to Executive’s employment with the Company, he will abide by the Inventions Policy. Executive further acknowledges that the Inventions Policy may be amended from time to time, and Executive agrees that this paragraph survives and applies to all
such amendments. 
  
 (c) Agreement Not to Compete.
Executive agrees that, both during employment and for a period of two (2) years following separation from employment for any reason (the “Non-Compete Period”), Executive will not directly or indirectly (on his own behalf or on
behalf of any other person or entity) engage in any business (or own an interest in an individual proprietorship, partnership, corporation, joint venture, trust or other form of business entity, whether as an individual proprietor, partner,
shareholder, joint venturer, officer, director, consultant, broker, employee, sales person, trustee, independent contractor, or in any manner whatsoever (except for an ownership interest not exceeding five percent (5%) of a publicly traded
entity), that is of the type and character or that is competitive with the Business (as defined below). The parties hereby agree that the Company is currently engaged in the business of developing products using technology for neutralizing gastrin
and targeting gastrin tumors that participate in gastrointestinal system cancer and non-cancer diseases (the “Business”). 
  
 (d) Agreement Not to Recruit the Company’s Employees. Executive agrees that, both during employment and for a period of two (2) years
following separation from employment for any reason (the “Non-Solicit Period”), Executive will not directly or indirectly (on his own behalf or on behalf of any other person or entity) recruit, solicit or otherwise induce any
Company employee or consultant, or any individual or entity that had been employed by or under contract with the Company during the Non-Solicit Period, to enter into an employment or a consulting relationship with any other business entity that
competes with the Company. 
  
 (e) Agreement Not to Solicit the
Company’s Clients/Customers. Executive agrees that, both during employment and until the end of the Non-Solicit Period, Executive will not directly or indirectly (on his own behalf or on behalf of any other person or entity), solicit any
business in any way related to the Business from any Clients/Customers of the Company, or divert or attempt to divert from the Company any business relationship which existed between the Company and any Clients/Customers. For purposes of this
Agreement, Clients/Customers shall include any person or entity: 1) that was a client of the Company with which Executive had contact in the course of his business responsibilities during the twelve (12) month period immediately preceding the
end of Executive’s employment; and 2) about which Executive gained confidential or proprietary information belonging to the client or Company. Customer shall also mean specifically sanofi-aventis, Xoma (US) LLC, Daiichi Pure Chemicals Co.,
Ltd., GlaxoSmithKline, Schering Plough, Institut für angewandte Mikrobiologie/BOKU, Pharmakologisches Institut/Prof. Freissmuth, Huntingdon, Ryle, Prentice, and UCL and their respective affiliates. 
  
 (f) Reasonableness of this Section 7. Executive agrees that the
provisions of this Section 7 are reasonable and necessary for the protection of the Company’s Confidential Information; its Clients/Customers’ Confidential Information; its business relationships with its Clients/Customers; and its
undisrupted workplace. 
  

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 (g) Notice to New Employer. Executive agrees that, prior to the commencement of any new employment
or consultation with a person or entity in any business in which the Company operated during Executive’s employment, he will advise the person or entity of the terms of Section 7 of this Agreement. The Executive also agrees that the
Company may advise any new or prospective employer of the existence and terms of this Agreement and may furnish said employer or consultant with a copy of the relevant provisions of this Agreement. 
  
 (h) Absence of Geographic Description; Savings Clause. Executive
acknowledges that there are no geographic restrictions contained in this Section 7 because the Company’s business is international, Executive’s responsibilities include, among other things, developing business internationally and
neither the business of the Company nor Executive’s activities has been or will be limited to any one geographic area. Notwithstanding, if a court of competent jurisdiction finds any or all of the foregoing paragraphs invalid for lack of
a specific geographic restriction, Executive agrees that the applicable geographical restriction is the United States or such lesser or greater geographic area in which Executive worked or solicited Clients/Customers at any time during his
employment. 
  
 (i) No Conflict With Obligations. Executive
promises and represents that his employment with the Company is not in conflict with any obligations he owes to any other person or entity. Executive will notify the Company in writing before performing or causing to be performed any work for or on
behalf of the Company which appears to be in conflict with: (a) rights of any nature owned or claimed by Executive in any Invention or Idea or Confidential Information, as defined in the appropriate Company Policies, conceived by him prior to
beginning work with the Company; (b) rights arising out of obligations incurred by Executive prior to beginning work for the Company; or (c) Executive’s obligations to the Company under this Agreement. In the event of Executive’s
failure to give notice of any such conflict, the Company may conclude that no such conflict exists, and Executive agrees, in such event, to make no claim against the Company with respect to the use of any such Invention or Idea or Confidential
Information by the Company. 
  
 (j) Remedies for Breaches of
Section 7. In the event of a breach or potential breach of this Section 7, Executive acknowledges that the Company and its affiliates will be caused irreparable injury and that money damages may not be an adequate remedy and agree that
the Company and its affiliates shall be entitled to injunctive relief (in addition to its other remedies at law) to have the provisions of this Section 7 enforced. It is hereby acknowledged that the provisions of this Section 7 are for the
benefit of the Company and all of the affiliates of the Company and each such entity may enforce the provisions of this Section 7 and only the applicable entity can waive the rights hereunder with respect to its confidential information and
Executives. Furthermore, in the event of a breach of this Section 7 by Executive while amounts under Section 6 hereof are due and owing, Executive shall not be entitled to receive any future amounts owed under Section 6 hereof, other
than payment of accrued amounts and accrued benefits, but the Company shall remain entitled to injunctive relief in addition to any other remedies at law. In the event that the Company has breached any of its obligations to make 
  

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 payments to Executive under Section 6 hereof, and such breach is not remedied within 30 days of written notice, then
Executive shall be relieved of his obligations under Sections 7(c), (d) and (e) hereof; provided, however, that from the date that the Company shall have remedied such breach, and paid all amounts owed under Section 7,
the Executive shall not take any future steps that would be in violation of Section 8(c), (d) or (e) until the end of the Non-Compete Period or the Non-Solicit Period, as the case may be; provided further, however, that
in event that prior to the Company’s remedy of the breach, Executive becomes engaged in activities that would violate Sections 8(c), (d) or (e), except for this Section 8(j), then, upon the Company’s remedy of such breach,
Executive shall be permitted to continue to engage in such activities, to the extent of such prior activity, subsequent to the Company’s remedy. 
  
 8. Indemnification. The Company shall indemnify and hold harmless Executive to the extent provided in the Certificate of Incorporation and By-Laws
of the Company for any action or inaction of Executive while serving as an officer and director of the Company or, at the Company’s request, as an officer or director of any other subsidiary or affiliate of the Company or as a fiduciary of any
benefit plan. The Company shall cover Executive under directors and officers’ liability insurance both during and, while potential liability exists, after the Employment Term in the same amount and to the same extent as the Company covers its
other officers and directors. 
  
 9. Gross-Up Payment.

  
 (a) Amount. If any payment or benefit
provided to Executive by the Company (a “Base Payment”) is subject to the tax (the “Excise Tax”) imposed by Section 4999 of the Internal Revenue Code of 1986, as amended (the “Code”) (or any
other similar tax that may hereafter be imposed), the Company shall pay to Executive the “Gross-Up Payment” determined as follows. The “Gross-Up Payment” shall be equal to the sum of (i) the Excise Tax imposed with
respect to the Base Payment, plus (ii) the Excise Tax imposed with respect to the Gross-Up Payment, plus (iii) all other taxes imposed on Executive with respect to the Gross-Up Payment, including income taxes and Executive’s share of
FICA, FUTA and other payroll taxes. The Gross-Up Payment shall not include the payment of any tax on the Base Payment other than the Excise Tax. The Gross-Up Payment is intended to place Executive in the same economic position Executive would have
been in if the Excise Tax did not apply, and shall be calculated in accordance with such intent. 
  
 (b) Tax Rates and Assumptions. For purposes of determining the amount of the Gross-Up Payment, Executive shall be deemed to pay
Federal income taxes at the highest marginal rate of Federal income taxation in the calendar year in which the Gross-Up Payment is to be made, and state and local income taxes at the highest marginal rate of taxation in the state and locality of
Executive’s residence on the date of termination, net of the maximum reduction in Federal income taxes which could be obtained from deduction of such state and local taxes. 
  
 (c) Payment and Calculation Procedures. The Gross-Up Payment attributable to a Base Payment shall be
paid to Executive in cash and at such times as such Base Payment 
  

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 is paid or provided pursuant to this Agreement. Simultaneously with or prior to the Company’s
payment of a Base Payment, the Company shall deliver to Executive a written statement specifying the total amount of the Base Payment and the Excise Tax and Gross-Up Payment relating to the Base Payment, if any, together with all supporting
calculations and conclusions. If Executive disagrees with the Company’s determination of the Excise Tax or Gross-Up Payment, Executive shall submit to the Company, no later than thirty (30) days after receipt of the Company’s written
statement, a written notice advising the Company of the disagreement and setting forth Executive’s calculation of said amounts. Executive’s failure to submit such notice within such period shall be conclusively deemed to be an agreement by
Executive as to the amount of the Excise Tax and Gross-Up Payment, if any. If the Company agrees with Executive’s calculations, it shall pay any shortfall in the Gross-Up Payment to Executive within twenty (20) days after receipt of such a
notice from Executive. If the Company does not agree with Executive’s calculations, it shall provide Executive with a written notice within twenty (20) days after the receipt of Executive’s calculations advising Executive that the
disagreement is to be referred to an independent accounting firm for resolution. Such disagreement shall be referred to an independent accounting firm which is not the regular accounting firm of the Company and which is designated by the Company.
The Company shall be required to designate such accounting firm within ten (10) days after issuance of the Company’s notice of disagreement. The accounting firm shall review all information provided to it by the parties and submit a
written report to the parties setting forth its calculation of the Excise Tax and the Gross-Up Payment within fifteen (15) days after submission of the matter to it, and such decision shall be final and binding on all of the parties. The fees
and expenses charged by said accounting firm shall be paid by the Company. If the amount of the Gross-Up Payment actually paid by the Company was less than the amount calculated by the accounting firm, the Company shall pay the shortfall to
Executive within five (5) days after the accounting firm submits its written report. If the amount of the Gross-Up Payment actually paid by the Company was greater than the amount calculated by the accounting firm, Executive shall pay the
excess to the Company within fifteen (15) days after the accounting firm submits its written report. 
  
 (d) Subsequent Recalculation. In the event the Internal Revenue Service or other applicable governmental authority imposes an
Excise Tax with respect to a Base Payment that is greater than the amount of the Excise Tax determined pursuant to the immediately preceding paragraph, the Company shall reimburse Executive for the full amount of such additional Excise Tax plus any
interest and penalties which may be imposed in connection therewith, and pay to Executive a Gross-up Payment sufficient to make Executive whole and reimburse Executive for any Excise Tax, income tax and other taxes imposed on the reimbursement of
such additional Excise Tax and interest and penalties, in accordance with the principles set forth above. 
  
 10. Miscellaneous. 
  
 (a) Arbitration. (i) All disputes arising out of or relating to this Agreement, other than those arising out of the
Company’s enforcement of Section 7 hereof, that cannot be settled by the parties shall be settled by arbitration in Philadelphia, Pennsylvania, pursuant to the rules and regulations then obtaining of the American Arbitration Association.
The decision of the arbitrators shall be final and binding upon the parties, and judgment upon such decision may be entered in any court of competent jurisdiction. 
  

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 (ii) Discovery shall be allowed pursuant to the intendment of the United States Federal Rules of Civil
Procedure and as the arbitrators determine appropriate under the circumstances. 
  
 (iii) The arbitration tribunal shall be formed of three arbitrators, one to be appointed by each party and the third to be appointed by the first two arbitrators. Such arbitrators shall be required to apply the
contractual provisions hereof in deciding any matter submitted to them. 
  
 (iv) The costs and expenses of such arbitration shall be borne by the Company. The Company shall pay or reimburse Executive for all reasonable attorneys’ fees and costs incurred by Executive in prosecuting or
defending any claim under this Agreement and any such arbitration proceeding, unless the arbitrator(s) shall determine in their award that Executive has not prevailed with respect to at least one material claim or issue in such dispute in which
case Executive shall repay any amounts paid or advanced to Executive in connection with such dispute. 
  
 (b) Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of
Pennsylvania without reference to principles of conflict of laws. 
  
 (c) Entire Agreement/Amendments. This Agreement and the instruments contemplated herein, contain the entire understanding of the parties with respect to the employment of Executive by the Company from
and after the Commencement Date and supersedes any prior agreements between the Company and Executive with respect thereto, (but not the terms of, or rights under any equity or benefit plans or grants existing on the date hereof). There are no
restrictions, agreements, promises, warranties, covenants or undertakings between the parties with respect to the subject matter herein other than those expressly set forth herein and therein. This Agreement may not be altered, modified, or amended
except by written instrument signed by the parties hereto. 
  
 (d) No Waiver. The failure of a party to insist upon strict adherence to any term of this Agreement on any occasion shall not be considered a waiver of such party’s rights or deprive such party of
the right thereafter to insist upon strict adherence to that term or any other term of this Agreement. Any such waiver must be in writing and signed by Executive or an authorized officer of the Company, as the case may be. 
  
 (e) Legal and Other Fees and Expenses. Any reasonable
costs or expenses arising out of the interpretation or application of this Agreement or any term or condition of this Agreement, other than with respect to Section 7 hereof or as covered by Section 10 hereof, shall be the responsibility of
the Company; provided, however, that Executive shall repay any amounts paid or advanced to Executive in connection with a dispute or any litigation if Executive is not the prevailing party with respect to at least one material claim or

  

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 issue in such dispute or litigation. Any reasonable costs or expenses of Executive arising out of a
dispute or litigation regarding the interpretation or application of Section 7 hereof shall be the responsibility of Executive; provided, however, that Company shall reimburse Executive any amounts paid by Executive in connection
with such dispute or litigation if the Company is not the prevailing party of such dispute or litigation. The provisions of this subsection shall survive the expiration or termination of the Agreement and Executive’s employment hereunder.

  
 (f) Assignment. This Agreement
shall not be assignable by Executive. This Agreement shall be assignable by the Company only to an entity which is owned, directly or indirectly, in whole or in part by the Company or by any successor to the Company or an acquirer of all or
substantially all of the assets of the Company or all or substantially all of the assets of a group of subsidiaries and divisions of the Company, provided such entity or acquirer promptly assumes all of the obligations hereunder of the Company in a
writing delivered to Executive and otherwise complies with the provisions hereof with regard to such assumption. Upon such assignment and assumption, all references to the Company herein shall be to the assignee entity or acquirer, as the case may
be. 
  
 (g) Successors; Binding Agreement;
Third Party Beneficiaries. This Agreement shall inure to the benefit of and be binding upon the personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees legatees and permitted assignees of
the parties hereto. In the event of the Executive’s death while receiving amounts payable pursuant to Section 6 hereof, any remaining amounts shall be paid to Executive’s estate. 
  
 (h) Communications. For the purpose of this Agreement, notices
and all other communications provided for in this Agreement shall be in writing and shall be deemed to have been duly received (i) on the same business day when faxed or delivered, personally or by confirmed facsimile transmission prior to 5:00
p.m. Philadelphia time, (ii) three (3) business days after being mailed by United States registered or certified mail, return receipt requested, postage prepaid, or (iii) one (1) business day after being sent by a reputable
overnight courier, addressed to the respective addresses set forth below, provided that all notices to the Company shall be directed to the attention of the person below or to such other address as any party may have furnished to the other in
writing in accordance herewith. Notice of change of address shall be effective only upon receipt. Notices and all other communications shall be addressed to each party at its address or facsimile number set forth below: 
  

			
	if to Executive:	  	Manfred Ruediger
		
	 	  	___________________
		
	 	  	___________________
		
	 	  	Facsimile:
		
	with a copy to:	  	 
		
	if to the Company:	  	Aphton Corporation
	 	  	8 Penn Center, Suite 2300
	 	  	1628 JFK Blvd.
	 	  	Philadelphia, PA 19103
	 	  	Attention: Patrick T. Mooney, Chief Executive Officer
	 	  	                 John M. McCafferty, Corporate Counsel
	 	  	Facsimile: (215) 218-4356

  

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	with a copy to:	  	Akerman Senterfitt
	 	  	One Southeast Third Avenue, 28th Floor
	 	  	Miami, FL 33131
	 	  	Attention: Kara L. MacCullough
	 	  	Facsimile: (305) 374-5095

  
 (h) Withholding
Taxes. The Company may withhold from any and all amounts payable under this Agreement such U.S. or foreign federal, state and local taxes, as may be required to be withheld pursuant to any applicable law or regulation. 
  
 (i) Survivorship. The respective rights and obligations of the
parties hereunder, including without limitation Section 7 hereof, shall survive any termination of Executive’s employment to the extent necessary to the agreed preservation of such rights and obligations. 
  
 (j) Counterparts. This Agreement may be signed in counterparts,
each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument. 
  
 (k) Headings. The headings of the sections contained in this Agreement are for convenience only and shall not be deemed to control or affect
the meaning or construction of any provision of this Agreement. 
  
 (l) Executive’s Representation. Executive represents and warrants to the Company that there is no legal impediment to him entering into, or performing his obligations under this Agreement and neither entering into this
Agreement nor performing his contemplated service hereunder will violate any agreement to which he is a party or any other legal restriction. Executive further represents and warrants that in performing his duties hereunder he will not use or
disclose any confidential information of any prior employer or other person or entity. 
  

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 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement effective as of the day and year first above
written. 
  

			
	APHTON CORPORATION
		
	By:	 	 /s/ Patrick T. Mooney, M.D.

	Name:	 	Patrick T. Mooney, M.D.
	Title:	 	Chief Executive Officer and President

  

	
	EXECUTIVE
	
	 /s/ Manfred Ruediger

	Manfred Ruediger, PhD

  

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