Document:

Second
AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

 

This Second Amended and
Restated Registration Rights Agreement (this “Agreement”) is made and entered into as of September 16, 2011,
by and between OptimizeRx Corporation, a Nevada corporation (the “Company”), and Vicis Capital Master Fund,
a sub-trust of Vicis Capital Series Master Trust, a unit trust organized and existing under the laws of the Cayman Islands (“Vicis”).
Physicians Interactive Inc., a Delaware corporation (“PI”), which was a party to the Prior Agreement (as defined
below), is not a party to this Agreement pursuant to that certain Termination Agreement and Release by and among the Company, OptimizeRx
Corporation , a Michigan corporation, Vicis, Physicians Interactive Holdings, LLC, a Delaware limited liability corporation, and
PI dated of even date herewith (the “Termination and Release”). This Agreement amends and restates the Prior Agreement.

 

WHEREAS, in connection
with the purchase by Vicis of shares of Series B Convertible Preferred Stock, par value $0.001 per share, of the Company (the “Series
B Preferred Stock”) pursuant to the Securities Purchase Agreement, dated as of June 4, 2010, by and between the Company
and Vicis (the “Series B Purchase Agreement”), the Company and Vicis entered into the Registration Rights Agreement,
dated as of June 4, 2010 (“the Original Agreement”).

 

WHEREAS, pursuant to the
Securities Purchase Agreement, dated October 5, 2010, between the Company and PI, the Company, PI and Vicis entered into a Second
Amended and Restated Registration Rights Agreement amending and restating the Original Agreement (the “Prior Agreement”).

 

WHEREAS, pursuant to the
Securities Purchase Agreement, dated of even date herewith (the “September Purchase Agreement”), Vicis has agreed to
purchase additional shares of Series B Preferred Stock and additional warrants to purchase Common Stock of the Company.

 

WHEREAS, Vicis’s
obligation to consummate the transactions contemplated by the September Purchase Agreement is conditioned upon the execution and
delivery of this Agreement.

 

WHEREAS, in connection
with the consummation of the transactions contemplated by the Purchase Agreement, the Company and Vicis each desire to amend and
restate the Prior Agreement in its entirety to remove PI as a party to this Agreement (as authorized by the Termination and Release)
and make certain other changes with respect to the rights granted thereunder, as set forth herein.

NOW THEREFORE, in consideration
of the foregoing and of the mutual promises and covenants contained herein and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

 

1.Definitions.

 

As used in this Agreement, the following terms shall have the following
meanings:

    	 

    	 

    

“Agreement” means this Agreement,
as the same may be amended or supplemented from time to time in accordance with the terms hereof.

 

“Affiliate(s)”
has the meaning set forth in Rule 144.

 

“Additional Effectiveness
Deadline” has the meaning set forth in Section 2(b) of this Agreement.

 

“Additional Filing
Deadline” has the meaning set forth in Section 2(b) of this Agreement.

 

“Business Day”
means any day except Saturday, Sunday and any day which shall be a federal legal holiday or a day on which banking institutions
in the State of New York are authorized or required by law or other governmental action to close.

 

“Commission”
means the U.S. Securities and Exchange Commission.

 

“Common Stock”
means the common shares of the Company, $0.001 par value per share.

 

“Company”
has the meaning set forth in the preamble to this Agreement.

 

“Conversion Shares”
means the shares of Common Stock issuable upon conversion of the Preferred Shares.

 

“Effective Date”
means the date that a Registration Statement filed pursuant to Section 2(a) or Section 2(b), as applicable, is first declared effective
by the Commission.

 

“Effectiveness
Deadline” means, as applicable, the Initial Effectiveness Deadline and any Additional Effectiveness Deadline.

 

“Effectiveness
Period” has the meaning set forth in Section 2(a) of this Agreement.

 

“Exchange Act”
means the Securities Exchange Act of 1934, as amended, and the rules and regulations of the Commission thereunder.

 

“Filing Deadline”
has the meaning set forth in Section 2(b) of this Agreement.

 

“Grace Period”
has the meaning set forth in Section 4(g) of this Agreement.

 

“Holders”
means those Persons designated as “Holders” on the signature pages hereof and their respective successors and assigns.

 

“Indemnified Party”
has the meaning set forth in Section 6(c) of this Agreement.

 

“Indemnifying
Party” has the meaning set forth in Section 6(c) of this Agreement.

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“Initial Effectiveness
Deadline” has the meaning set forth in Section 2(a) of this Agreement.

 

“Initial Filing
Deadline” has the meaning set forth in Section 2(a) of this Agreement.

 

“Losses”
has the meaning set forth in Section 6(a) of this Agreement.

 

“Person”
means any individual, partnership, corporation, limited liability company, incorporated or unincorporated association, trust, joint
venture, unincorporated organization, joint stock company, governmental unit or other entity of any kind.

 

“Piggyback Notice”
has the meaning set forth in Section 3(a) of this Agreement.

 

“Piggyback Registration”
has the meaning set forth in Section 3(a) of this Agreement.

 

“Preferred Shares”
means shares of the Series B Preferred Stock held by a Holder.

 

“Proceeding”
means an action, claim, suit, investigation or proceeding (including, without limitation, an investigation or partial proceeding,
such as a deposition), whether commenced or threatened.

 

“Prospectus”
means the prospectus included in a Registration Statement (including, without limitation, a prospectus that includes any information
previously omitted from a prospectus filed as part of an effective registration statement in reliance upon Rule 430A or 430B promulgated
under the Securities Act), as amended or supplemented by any prospectus supplement, with respect to the terms of the offering of
any portion of the Registrable Securities covered by a Registration Statement, and all other amendments and supplements to the
Prospectus, including post-effective amendments, and all material incorporated by reference or deemed to be incorporated by reference
in such Prospectus.

 

“Registrable Securities”
means (i) the Shares (as hereinafter defined); and (ii) shares of Common Stock issued as dividends on the Series B Preferred Stock
or the Shares.

 

“Registration
Statement” means collectively: (i) the initial registration statement which is required to register the resale of the
Registrable Securities pursuant to Section 2(a), and (ii) each additional registration statement, if any, contemplated by Section
2(b), and including, in each case, the Prospectus, amendments and supplements to each such registration statement or Prospectus,
including pre- and post-effective amendments, all exhibits thereto, and all material incorporated by reference or deemed to be
incorporated by reference in such registration statement.

 

“Rule 144”
means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.

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“Rule 415”
means Rule 415 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.

 

“Rule 424”
means Rule 424 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time to time, or
any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.

 

“Securities Act”
means the Securities Act of 1933, as amended, and the rules and regulations of the Commission thereunder.

 

“Series B Preferred
Stock” has the meaning set forth in the Recitals.

 

“Series B Warrant”
means the Series B Warrants to purchase shares of Common Stock issued to Vicis pursuant to the Series B Purchase Agreement and
the September Purchase Agreement.

 

“Shares”
means the Conversion Shares and the Warrant Shares.

 

“Unregistered
Registrable Securities” has the meaning set forth in Section 2(b) of this Agreement.

 

“Underwritten
Offering” means a registration in which securities of the Company are sold to an underwriter for reoffering to the public.

 

“Warrant Shares”
means the shares of Common Stock issuable upon exercise of the Warrants.

 

“Warrants”
means the Series B Warrant.

 

2. Demand Registration Rights.

 

(a) Initial Filing &
Effectiveness Deadlines.

 

(i) If, at any time and
from time to time after the effectiveness of this Agreement, any Holder or group of Holders shall deliver a written request to
the Company (a “Registration Request”) containing the matters set forth in the next following sentence, the
Company shall within 30 days of receiving such request file with the Commission (an “Initial Filing Deadline”)
a Registration Statement for an offering on a continuous or delayed basis pursuant to Rule 415 covering the resale of Registrable
Securities held by the requesting Holder or Holders; provided that any such Registration Request which relates solely to
the registration of Conversion Shares shall require the written request of a Holder or group of Holders owning at least 75% of
the Registrable Securities (including all Registrable Securities underlying the Preferred Shares and the Warrants). Each Registration
Request shall certify the following (i) the number of Registrable Securities held by the Holder making such Registration Request;
and (ii) if less than all, the number of Registrable Securities of the requesting Holder to be covered by the Registration Statement.
The requesting Holder shall give notice to the other Holders of its Registration Request at the same time as the requesting Holder
delivers the request to the Company; and the other Holders shall have the right to include any or all of their Registrable Securities
on such Registration Statement if it or they provide the Company with the necessary information regarding such Holder and the applicable
Registrable Securities to be included in the Registration Statement within 10 Business Days of such request, subject to Section
2(c). Subject to the agreement of the Holders registering Registrable Securities, the Company shall also have the right to include
any of its securities on such Registration Statement, subject to Section 2(c).

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(ii) The Company shall
use its best efforts to cause any Registration Statement filed in response to a request pursuant to Section 2(a)(i) to be declared
effective under the Securities Act as soon as possible but, in any event, no later than the earlier of:

 

(A) 180 days after the
Initial Filing Deadline, and

 

(B) the twentieth Business
Day following the date on which the Company is notified by the Commission that the Registration Statement filed pursuant to Section
2(a)(i) will not be reviewed or is no longer subject to further review and comments (an “Initial Effectiveness Deadline”),
and shall use its best efforts to keep the Registration Statement continuously effective under the Securities Act until the earliest
of:

 

(i) the date when all Registrable
Securities covered by the Registration Statement have been sold;

 

(ii) the date when all
Registrable Securities have been sold pursuant to Rule 144;

 

(iii) the date when all
Registrable Securities covered by the Registration Statement may be sold without restriction pursuant to Rule 144, as determined
by counsel to the Company pursuant to a written opinion letter to such effect, upon receipt by the Holders of a notice from the
Company stating that the Company will deliver certificates without restrictive legends upon surrender by the Holders of the existing
certificates along with appropriate seller’s and broker’s representation letters;

 

(iv) the date two years
after the date that the Registration Statement is declared effective by the Commission; or

 

(v) the date when all Registrable
Securities cease to be outstanding (together, the “Effectiveness Period”).

 

(b) Possible Subsequent
Registration. If the Commission does not permit all of the Registrable Securities to be included in the Registration Statement
initially filed pursuant to Section 2(a)(i) as a result of the Commission’s application of Rule 415, then the Company shall
prepare and file as soon as possible after the date on which the Commission indicates as being the first date or time that such
filing may be made (which shall be the later of sixty (60) days following the sale of substantially all of the Registrable Securities
included in such initial Registration Statement or six months following the Effective Date of such initial Registration Statement),
but in any event by the 10th Business Day following such date or, in the event the Commission does not so indicate, no later than
six months after the Effective Date of the Registration Statement filed pursuant to Section 2(a)(i) (an “Additional Filing
Deadline” and, together with an Initial Filing Deadline, a “Filing Deadline”), an additional Registration
Statement covering the resale of all Registrable Securities not already covered by an existing and effective Registration Statement
for an offering to be made on a continuous or delayed basis pursuant to Rule 415. The Company shall use its best efforts to cause
each such Registration Statement to be declared effective under the Securities Act as soon as possible but, in any event, no later
than 90 days following the date on which the Company becomes aware that such Registration Statement is required to be filed under
this Agreement (an “Additional Effectiveness Deadline” for such Registration Statement), and shall use its best
efforts to keep such Registration Statement continuously effective under the Securities Act during the Effectiveness Period. To
the extent the staff of the Commission does not permit all of the Registrable Securities that have not yet been covered on an effective
Registration Statement (the “Unregistered Registrable Securities”) to be registered on such additional Registration
Statement, the Company shall file one or more additional Registration Statements successively trying to register on each such successive
Registration Statement the maximum number of Unregistered Registrable Securities permitted by the Commission until all of the Registrable
Securities have been registered with the Commission, subject to any subsequent Filing Deadline and subsequent Effectiveness Deadline
and in accordance with the agreements of the Company contained in this Section 2(b). In the event that on the filing date of the
applicable additional Registration Statement, the Company’s financial statements would be “stale” (more than
135 days old), the Company shall have ten (10) days from the date that the applicable financial statements are filed with the Commission
as part of a 10-K or 10-Q filing to file such additional Registration Statement.

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(c) Allocation of Registrable
Securities in Registration Statement. The initial number of Registrable Securities included in any Registration Statement and
any increase in the number of Registrable Securities included therein shall be allocated pro rata among the Holders (based on the
number of Registrable Securities held by each Holder), and any securities of the Company to be included in such Registration Statement
at the time the Registration Statement covering such initial number of Registrable Securities or increase thereof is filed with
the Commission. In the event that a Holder sells or otherwise transfers any of such Holder’s Registrable Securities, each
transferee shall be allocated a pro rata portion of the then remaining number of Registrable Securities included in such Registration
Statement for such transferor. Any Registrable Securities included in a Registration Statement which remain allocated to any Person
which ceases to hold any Registrable Securities covered by such Registration Statement shall be allocated to the remaining Holders,
pro rata based on the number of Registrable Securities then held by such Holders which are covered by such Registration Statement.

 

(d) Holder Cooperation.
Each Holder hereby agrees:

 

(i) to cooperate with the
reasonable requests of Company in connection with the preparation and filing of any Registration Statement hereunder by providing
the Company with information regarding such Holder which was requested by the Company in writing in order to effect the registration
of such Holder’s Registrable Securities, including if requested, a statement as to (i) the identity of the beneficial owner
of the Registrable Securities, (ii) the number of Registrable Securities beneficially owned by such Holder and any Affiliate thereof
and (iii) the intended method of distribution of such Registrable Securities included in such Registration Statement, unless such
Holder has notified the Company in writing of such Holder’s election to exclude all of such Holder’s Registrable Securities
from such Registration Statement; and

 

(ii) upon receipt of a
notice from the Company of the occurrence of any event of the kind described in Section 4(h)(iii) such Holder will discontinue
disposition of such Registrable Securities under the Registration Statement until such Holders’ receipt of the copies of
the supplemented Prospectus and/or amended Registration Statement or until it is advised in writing by the Company that the use
of the applicable Prospectus may be resumed.

 

3. Piggyback Registration
Rights.

 

(a) Right to Piggyback.
If at any time, and from time to time, the Company proposes to file a registration statement under the Securities Act with respect
to an offering of any class of equity or equity-linked securities of the Company (other than a registration statement (i) on Form
S-4, Form S-8 or in each case any successor forms thereto, (ii) in respect of a dividend reinvestment or similar plan for shareholders
of the Company or (iii) filed in connection with an offering made solely to existing shareholders or employees of the Company),
whether or not for its own account, then the Company will give written notice (the “Piggyback Notice”) of such
proposed filing to the Holders at least 30 days before the anticipated filing date. Such notice will offer the Holders the opportunity
to register such amount of Registrable Securities as each Holder may request on the same terms and conditions as the proposed registration
that gave rise to the Piggyback Notice (a “Piggyback Registration”). The Company will include in each Piggyback
Registration all Registrable Securities for which the Company has received written requests from Holders for inclusion within ten
Business Days after delivery of the Piggyback Notice, subject to Section 3(b).

 

(b) Priority on Piggyback
Registrations. If the Piggyback Registration is an Underwritten Offering, the Company will cause the managing underwriter of
that proposed offering to permit the Holders that have requested Registrable Securities to be included in the Piggyback Registration
to include all such Registrable Securities on the same terms and conditions as any similar securities, if any, of the Company or
any other applicable selling securityholder. The right of any Holder to participate in any such Underwritten Offering shall be
conditioned on such Holder’s entering into an underwriting agreement in customary form with the underwriter or underwriters
selected by the Company. Notwithstanding the foregoing, if the managing underwriter or underwriters of such Underwritten Offering
advises the Company and the selling Holders in writing that, in its good faith determination, the total amount of securities that
the Company and the Holders propose to include in such offering is such as to materially and adversely affect the success of such
Underwritten Offering or that if the managing underwriter of an Underwritten Offering under this Section 3(b) advises the Company
and such Holders in writing that the total number of shares requested to be included in such registration exceeds the number of
shares of Common Stock which can be sold in such offering or that the success or pricing of the offering would be materially and
adversely affected by the inclusion of all of the shares of Common Stock requested to be included, then:

 

(i) if such Piggyback
Registration is a primary registration by the Company for its own account, the Company will include in such Piggyback Registration
in the following order of priority: (A) first, the full amount of securities proposed to be offered by the Company; (B) second,
up to the full amount of securities requested to be included in such Piggyback Registration by the Holders making such Piggyback
Request, allocated pro rata among such Holders, on the basis of the amount of securities requested to be included therein by each
such Holder; and (C) third, any other securities requested to be included in such registration so that the total amount of securities
to be included in such Underwritten Offering is the full amount that, in the opinion of such managing underwriter, can be sold
without materially and adversely affecting the success of such Underwritten Offering; and

 

(ii) if such Piggyback
Registration is an underwritten secondary registration for the account of holders of securities of the Company, the Company will
include in such registration, in the following order of priority: (A) first, the full amount of securities proposed to be included
in the registration pursuant to arrangements entered into or proposed to be entered into among the Company and the holders of securities
of the Company for whose account such underwritten secondary registration is being undertaken; (B) second, up to the full amount
of securities requested to be included in such Piggyback Registration by the Holders making such Piggyback Request, allocated pro
rata among such Holders, on the basis of the amount of securities requested to be included therein by each such Holder; and (C)
third, any other securities requested to be included in such registration so that the total amount of securities to be included
in such Underwritten Offering is the full amount that, in the written opinion of such managing underwriter, can be sold without
materially and adversely affecting the success of such Underwritten Offering.

 

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(iii) If so requested (pursuant
to a timely written notice) by the managing underwriter in any Underwritten Offering, the Holders participating in such Underwritten
Offering will agree not to effect any public sale or distribution (or any other type of sale, offer, disposition or other transaction
as the managing underwriter determines is necessary in order to effect the Underwritten Offering) of any Common Stock or similar
securities, including a sale pursuant to Rule 144 (but excluding any Registrable Securities included in such Underwritten Offering),
during the 10 days prior to, and during (A) for an initial public offering of Common Shares or other similar securities of the
Company, 180 days and (B) for a secondary offering of Common Shares or other similar securities of the Company, 90 days, in each
case (or such additional period as the managing underwriter determines is necessary in order to effect the Underwritten Offering),
following, the pricing date of such Underwritten Offering (or such longer period as may be required by the applicable underwriting
agreement). In the event of such a request, the Company may impose, during such period, appropriate stop-transfer instructions
with respect to the Common Stock or similar securities subject to such restrictions.

 

(c) Withdrawal of Piggyback
Registration.

 

(i) If at any time after
giving the Piggyback Notice and prior to the effective date of the Registration Statement filed in connection with the Piggyback
Registration, the Company determines for any reason to delay or not to register the Piggyback Registration, the Company may, at
its election, give written notice of its determination to all Holders, and (A) in the case of a determination not to register,
will be relieved of its obligation to register any Registrable Securities in connection with the abandoned Piggyback Registration,
without prejudice, and (B) in the case of a determination to delay the Piggyback Registration, will be permitted to delay the registration
for the same period.

 

(ii) Any Holder of Registrable
Securities requesting to be included in a Piggyback Registration may withdraw its request for inclusion by giving written notice
to the Company of its intention to withdraw from that registration, provided, however, (A) the Holder’s request must be made
in writing, in the case of an Underwritten Offering, at least five Business Days prior to the anticipated effective date of the
applicable Registration Statement, or if the registration is not an Underwritten Offering, at least five Business Days prior to
the anticipated filing date of the applicable Registration Statement covering the Piggyback Registration, and (B) the withdrawal
will be irrevocable and, after making the withdrawal, a Holder will no longer have any right to include its Registrable Securities
in that Piggyback Registration.

 

(iii) The Company shall
be deemed to have satisfied its obligations with respect to any Piggyback Registration to any Holder under this Section 3 notwithstanding
an election to withdraw under this Section 3(c).

 

4. Registration Procedures.

 

In connection with the
Company’s registration obligations hereunder, the Company shall:

 

(a) Registration Statement
Form. In the event that Form S-3 is not available for the registration of the resale of Registrable Securities covered by this
Agreement, the Company shall (i) register the resale of the Registrable Securities on another appropriate form and (ii) undertake
to register the Registrable Securities on Form S-3 as soon as such form is available, provided that the Company shall maintain
the effectiveness of the Registration Statement then in effect until such time as a Registration Statement on Form S-3 covering
the Registrable Securities has been declared effective by the Commission.

 

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(b) Rule 424 Prospectus
Filing. By 9:30 am, New York City time, on the Business Day following the applicable Effective Date and immediately following
the preparation of a supplement to a Prospectus, the Company shall file with the Commission in accordance with Rule 424 under the
Securities Act the applicable, final Prospectus to be used in connection with resales pursuant to such Registration Statement.

 

(c) Holder Review of
Filings. Not less than ten Business Days prior to the proposed filing of a Registration Statement or any related Prospectus
or any amendment or supplement thereto, the Company shall furnish to the Holders complete drafts of all such documents proposed
to be filed, and shall use its best efforts to reflect in each such document such comments as the Holders shall propose. The Company
shall not file a Registration Statement or any such Prospectus or any amendments or supplements thereto prior to correcting information
in such documents regarding a Holder to which such Holder shall object in good faith. Each Registration Statement, as of the applicable
Filing Date, the applicable Effective Date and each day thereafter during which such Registration Statement remains effective (including
all amendments or supplements thereto, as of their respective filing and effective dates and each day thereafter), shall not contain
any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made, not misleading, and the Prospectus contained in such
Registration Statement, as of its filing date and each day thereafter during which such Registration Statement remains effective
(including all amendments and supplements thereto, as of their respective filing dates and each day thereafter), shall not contain
any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made, not misleading.

 

(d) Holder Requests
for Inclusion of Information in Registration Statements & Prospectuses. If requested by a Holder, the Company shall (i)
as soon as possible, incorporate in a prospectus supplement or post-effective amendment such information as a Holder requests to
be included therein relating to the sale and distribution of Registrable Securities, including, without limitation, information
with respect to the number of Registrable Securities being offered or sold, the purchase price being paid therefor and any other
terms of the offering of the Registrable Securities to be sold in such offering; (ii) as soon as possible, make all required filings
of such prospectus supplement or post-effective amendment after being notified of the matters to be incorporated in such prospectus
supplement or post-effective amendment, except that the Company shall not be obligated to make any filings with FINRA’s Corporate
Finance Department; and (iii) as soon as possible, supplement or make amendments to any Registration Statement if requested by
a Holder holding any Registrable Securities.

 

(e) Requirement to File
Amendments and Supplements; Securities Law Compliance. The Company shall (i) prepare and file with the Commission such amendments,
including post-effective amendments, to each Registration Statement and the Prospectus used in connection therewith as may be necessary
to keep such Registration Statement continuously effective as to the applicable Registrable Securities for the Effectiveness Period
and prepare and file with the Commission such additional Registration Statements in order to register for resale under the Securities
Act all of the Registrable Securities if not otherwise covered by another Registration Statement; (ii) cause each Registration
Statement and the related Prospectus to be amended or supplemented by any post-effective amendment and any required prospectus
supplement or issuer “free writing prospectus” (as defined by Rule 405 promulgated by the Commission pursuant to the
Securities Act) as soon as possible so that such Registration Statement and Prospectus do not contain an untrue statement of a
material fact or omit to state a material fact required to be stated therein, including upon the occurrence of any event contemplated
by Section 4(h) or following a Grace Period contemplated by Section 4(g) that would require the filing of an amendment or supplement
to any Registration Statement or Prospectus to the extent that such Registration Statement or Prospectus would not then contain
a material misstatement or omission; (iii) respond as promptly as possible to any comments received from the Commission with respect
to each Registration Statement or any amendment thereto and, as promptly as possible provide the Holders true and complete copies
of all correspondence from and to the Commission relating to such Registration Statement that pertains to the Holders as selling
shareholders but not any comments that would result in the disclosure to the Holders of material and non-public information concerning
the Company; and (iv) comply in all material respects with the provisions of the Securities Act and the Exchange Act with respect
to any Registration Statement filed with the Commission and the disposition of all Registrable Securities covered by each such
Registration Statement.

 

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(f) Avoidance of Stop
Orders, etc. Use its best efforts to avoid the issuance of, or, if issued, obtain the withdrawal of (i) any order suspending
the effectiveness of a Registration Statement, or (ii) any suspension of the qualification (or exemption from qualification) of
any of the Registrable Securities for sale in any jurisdiction, at the earliest practicable moment.

 

(g) Grace Periods.
Notwithstanding anything to the contrary herein, at any time after the Effective Date of a Registration Statement, the Company
may delay the disclosure of material, non-public information concerning the Company the disclosure of which at such time is not,
in the good faith opinion of the board of directors of the Company, in the best interest of the Company and, in the opinion of
counsel to the Company, otherwise required to be disclosed pursuant to the Securities Act or the Exchange Act for a period of time
not to exceed an aggregate of 60 days in any 12 month period (any such period, a “Grace Period”); provided,
that the Company shall promptly (i) notify the Holders in writing of the existence of material, non-public information giving rise
to a Grace Period, provided that in each notice the Company will not disclose the content of such material, non-public information
to the Holders and the date on which the Grace Period will begin, and (ii) notify the Holders in writing of the date on which the
Grace Period ends. For purposes of determining the length of a Grace Period above, the Grace Period shall begin on and include
the date the Holders receive the notice referred to in clause (i) and shall end on and include the later of the date the Holders
receive the notice referred to in clause (ii) and the date referred to in such notice.

 

(h) Notices to Holders.
Notify the Holders as promptly as possible of the following:

 

(i) (A) when a Registration
Statement, Prospectus, any Prospectus supplement or post-effective amendment to a Registration Statement is proposed to be filed;
(B) when the Commission notifies the Company whether there will be a review of such Registration Statement by the staff of the
Commission and whenever the Commission comments in writing on such Registration Statement, the Company shall provide true and complete
copies thereof and all written responses thereto to each of the Holders that pertain to the Holders as selling shareholders or
to the Plan of Distribution section of the Prospectus, but not information which the Company believes would constitute material
and non-public information; and (C) with respect to each Registration Statement or any post-effective amendment, when the same
has become effective;

 

(ii) of any request by
the Commission or any other Federal or state governmental authority for amendments or supplements to a Registration Statement or
Prospectus or for additional information that pertains to the Holders as selling shareholders or the Plan of Distribution section
of the Prospectus; and

 

(iii) (A) of the issuance
by the Commission of any stop order suspending the effectiveness of a Registration Statement covering any or all of the Registrable
Securities or the initiation of any Proceedings for that purpose, including pursuant to Section 8A of the Securities Act; (B) of
the receipt by the Company of any notification with respect to the suspension of the qualification or exemption from qualification
of any of the Registrable Securities for sale in any jurisdiction, or the initiation or threatening of any Proceeding for such
purpose; or (C) of the occurrence of any event or passage of time (including due to the existence of a Grace Period) that makes
(I) the financial statements included in a Registration Statement ineligible for inclusion therein or stale under Regulation S-X
or (II) the Registration Statement, as of the applicable Filing Date, the applicable Effective Date and each day thereafter during
which such Registration Statement remains effective (including all amendments or supplements thereto, as of their respective filing
and effective dates and each day thereafter), contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were
made, not misleading, and the Prospectus contained in such Registration Statement, as of its filing date and each day thereafter
during which such Registration Statement remains effective (including all amendments and supplements thereto, as of their respective
filing dates and each day thereafter), contain any untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not
misleading.

 

    	9

    	 

    

(i) Delivery of Copies
to Holders.

 

(i) Furnish to each Holder,
without charge, at least one conformed copy of each Registration Statement and each amendment thereto and all exhibits to the extent
requested by such Person (including those previously furnished or incorporated by reference) promptly after the filing of such
documents with the Commission; provided, that the Company shall have no obligation to provide any document pursuant to this clause
that is available on the EDGAR system.

 

(ii) Promptly deliver to
each Holder, without charge, as many copies of each Prospectus or Prospectuses (including each form of prospectus) and each amendment
or supplement thereto as such Persons may request. The Company hereby consents to the use of such Prospectus and each amendment
or supplement thereto by each of the selling Holders in connection with the offering and sale of the Registrable Securities covered
by such Prospectus and any amendment or supplement thereto.

 

(j) Blue Sky. Prior
to any public offering of Registrable Securities, use its best efforts to register or qualify or cooperate with the selling Holders
in connection with the registration or qualification (or exemption from such registration or qualification) of such Registrable
Securities for offer and sale under the securities, Blue Sky or other laws of such jurisdictions or governmental authorities or
agencies within or outside the United States as any Holder may in writing request, and to keep each such registration or qualification
(or exemption therefrom) effective during the Effectiveness Period and to do any and all other acts or things necessary or advisable
to enable the disposition in such jurisdictions of the Registrable Securities covered by the Registration Statements; provided,
that the Company shall not be required to qualify generally to do business in any jurisdiction where it is not then so qualified
or subject the Company to any material tax or other material expense in any such jurisdiction where it is not then so subject.

 

(k) Certificates.
Cooperate with the Holders to facilitate the timely preparation and delivery of certificates representing Registrable Securities
to be delivered to a transferee pursuant to the Registration Statements, which certificates shall be free of all restrictive legends,
and to enable such Registrable Securities to be in such denominations and registered in such names as any such Holders may request.

 

(l) Notices to Transfer
Agent, Etc. Within ten Business Days after a Registration Statement which covers Registrable Securities is declared effective
by the Commission, or the Registrable Securities of such Holder are otherwise freely transferable pursuant to Rule 144, the Company
shall deliver to the transfer agent for such Registrable Securities confirmation. The Company shall cause its transfer agent to
deliver unlegended shares of Common Stock or Registrable Securities, as the case may be, to a transferee of a Holder in connection
with any sale of Registrable Securities with respect to which a Holder has entered into a contract for sale and the Company has
delivered the confirmation.

 

    	10

    	 

    

(m) Exchange Act Filings.
The Company shall timely file with the Commission (or obtain extensions in respect thereof and file within the applicable grace
period) all reports required to be filed by the Company pursuant to Section 13(a) or 15(d) of the Exchange Act. The Company will
take such further action as any Holder may request, all to the extent required from time to time to enable such Holder to sell
Registrable Securities without registration under the Securities Act within the limitation of the exemptions provided by Rule 144
promulgated under the Securities Act.

 

5. Registration Expenses.

 

All fees and expenses incident
to the Company’s performance of its obligations under this Agreement (excluding any underwriting discounts selling commissions
and share transfer taxes) shall be borne by the Company whether or not any Registrable Securities are sold pursuant to a Registration
Statement. The fees and expenses referred to in the foregoing sentence shall include, without limitation and whether or not this
Agreement is terminated, (i) all registration and filing fees (including, without limitation, fees and expenses with respect to
(A) applications and filings required to be made with the trading market, if any, on which the Common Stock is then listed for
trading, and (B) compliance with applicable state or non-U.S. securities or Blue Sky laws), (ii) printing expenses (including,
without limitation, expenses of printing certificates for Registrable Securities and of printing prospectuses if the printing of
prospectuses is requested by any of the Holders included in the Registration Statement), (iii) messenger, telephone and delivery
expenses of the Company, (iv) fees and disbursements of counsel for the Company, and (v) fees and expenses of all other Persons
or firms retained by the Company in connection with the consummation of the transactions contemplated by this Agreement.

 

6. Indemnification.

 

(a) Indemnification
by the Company. The Company shall, notwithstanding any termination of this Agreement, indemnify and hold harmless each Holder,
the officers, directors, managers, partners, members, shareholders, agents, brokers, investment advisors and employees of each
of them, each Person who controls any such Holder (within the meaning of Section 15 of the Securities Act or Section 20 of the
Exchange Act) and the officers, directors, agents and employees of each such controlling Person, to the fullest extent permitted
by applicable law, from and against any and all losses, claims, damages, liabilities, costs (including, without limitation, costs
of preparation and attorneys’ fees) and expenses (collectively, “Losses”), as incurred, arising out of
or relating to (i) any violation of securities laws or untrue or alleged untrue statement of a material fact contained in the Registration
Statement, any Prospectus or any form of prospectus or in any amendment or supplement thereto or in any preliminary prospectus,
or arising out of or relating to any omission or alleged omission of a material fact required to be stated therein or necessary
to make the statements therein (in the case of any Prospectus or form of prospectus or supplement thereto, in the light of the
circumstances under which they were made) not misleading, except to the extent, but only to the extent, that such untrue statements
or omissions are based solely upon information regarding such Holder or such other Indemnified Party furnished in writing to the
Company by such Holder expressly for use therein, or (ii) such Holder’s enforcement of the indemnification rights provided
for in this Section 5(a). The Company shall notify the Holders promptly of the institution, threat or assertion of any Proceeding
of which the Company is aware in connection with the transactions contemplated by this Agreement.

 

    	11

    	 

    

(b) Indemnification
by Holders. Each Holder shall, severally and not jointly, indemnify and hold harmless the Company, its directors, officers,
agents and employees, each Person who controls the Company (within the meaning of Section 15 of the Securities Act and Section
20 of the Exchange Act), and the directors, officers, agents and employees of such controlling Persons, to the fullest extent permitted
by applicable law, from and against all Losses (as determined by a court of competent jurisdiction in a final judgment not subject
to appeal or review or a judgment not appealed in the requisite time period), as incurred, arising solely out of or based solely
upon any untrue statement of a material fact contained in the Registration Statement, any Prospectus, or any form of prospectus,
or in any amendment or supplement thereto, or arising solely out of or based solely upon any omission of a material fact required
to be stated therein or necessary to make the statements therein (in the case of any Prospectus or form of prospectus or supplement
thereto, in the light of the circumstances under which they were made) not misleading, to the extent, but only to the extent, that
such untrue statement or omission is contained in any information so furnished in writing by such Holder to the Company specifically
for inclusion in the Registration Statement or such Prospectus. Notwithstanding anything to the contrary contained herein, each
Holder shall be liable under this Section 5(b) for only that amount as does not exceed the net proceeds to such Holder as a result
of the sale of Registrable Securities pursuant to such Registration Statement.

 

(c) Conduct of Indemnification
Proceedings. If any Proceeding shall be brought or asserted against any Person entitled to indemnity hereunder (an “Indemnified
Party”), such Indemnified Party promptly shall notify the Person from whom indemnity is sought (the “Indemnifying
Party”) in writing, and the Indemnifying Party shall be entitled to assume the defense thereof, including the employment
of counsel reasonably satisfactory to the Indemnified Party and the payment of all fees and expenses incurred in connection with
defense thereof; provided, that the failure of any Indemnified Party to give such notice shall not relieve the Indemnifying Party
of its obligations or liabilities pursuant to this Agreement, except (and only) to the extent that it shall be finally determined
by a court of competent jurisdiction (which determination is not subject to appeal or further review) that such failure shall have
proximately and materially adversely prejudiced the Indemnifying Party.

 

An Indemnified Party shall
have the right to employ separate counsel in any such Proceeding and to participate in the defense thereof, but the fees and expenses
of such counsel shall be at the expense of such Indemnified Party or Parties unless: (1) the Indemnifying Party has agreed in writing
to pay such fees and expenses; or (2) the Indemnifying Party shall have failed promptly to assume the defense of such Proceeding
and to employ counsel reasonably satisfactory to such Indemnified Party in any such Proceeding; or (3) the named parties to any
such Proceeding (including any impleaded parties) include both such Indemnified Party and the Indemnifying Party, and such parties
shall have been advised by counsel that a conflict of interest is likely to exist if the same counsel were to represent such Indemnified
Party and the Indemnifying Party (in which case, if such Indemnified Party notifies the Indemnifying Party in writing that it elects
to employ separate counsel at the expense of the Indemnifying Party, the Indemnifying Party shall not have the right to assume
the defense thereof and such counsel shall be at the expense of the Indemnifying Party). The Indemnifying Party shall not be liable
for any settlement of any such Proceeding effected without its written consent, which consent shall not be unreasonably withheld
or delayed. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any
pending or threatened Proceeding in respect of which any Indemnified Party is a party and indemnity has been sought hereunder,
unless such settlement includes an unconditional release of such Indemnified Party from all liability on claims that are the subject
matter of such Proceeding.

 

    	12

    	 

    

All fees and expenses of
the Indemnified Party (including reasonable fees and expenses to the extent incurred in connection with investigating or preparing
to defend such Proceeding in a manner not inconsistent with this Section) shall be paid to the Indemnified Party, as incurred,
within ten Business Days of written notice thereof to the Indemnifying Party (regardless of whether it is ultimately determined
that an Indemnified Party is not entitled to indemnification hereunder; provided, that the Indemnified Party shall reimburse all
such fees and expenses to the extent it is finally judicially determined that such Indemnified Party is not entitled to indemnification
hereunder).

 

(d) Contribution.
If a claim for indemnification under Section 6(a) or (b) is unavailable to an Indemnified Party (by reason of public policy or
otherwise), then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or
payable by such Indemnified Party as a result of such Losses, in such proportion as is appropriate to reflect the relative fault
of the Indemnifying Party on the one hand and the Indemnified Party on the other hand in connection with the actions, statements
or omissions that resulted in such Losses as well as any other relevant equitable considerations. The relative fault of such Indemnifying
Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including
any untrue or alleged untrue statement of a material fact or omission or alleged omission of a material fact, has been taken or
made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties’ relative intent,
knowledge, access to information and opportunity to correct or prevent such action, statement or omission. The amount paid or payable
by a party as a result of any Losses shall be deemed to include, subject to the limitations set forth in Section 6(c), any reasonable
attorneys’ or other reasonable fees or expenses incurred by such party in connection with any Proceeding to the extent such
party would have been indemnified for such fees or expenses if the indemnification provided for in this Section 6 was available
to such party in accordance with its terms.

 

The parties hereto agree
that it would not be just and equitable if contribution pursuant to this Section 6(d) were determined by pro rata allocation or
by any other method of allocation that does not take into account the equitable considerations referred to in the immediately preceding
paragraph. Notwithstanding the provisions of this Section 6(d), no Holder shall be required to contribute, in the aggregate, any
amount in excess of the amount by which the proceeds actually received by such Holder from the sale of the Registrable Securities
subject to the Proceeding exceeds the amount of any damages that such Holder has otherwise been required to pay by reason of such
untrue or alleged untrue statement or omission or alleged omission.

 

No person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to indemnification or contribution
from any person who was not guilty of such fraudulent misrepresentation.

 

The indemnity and contribution
agreements contained in this Section 6 are in addition to any other liability that the Indemnifying Parties may have to the Indemnified
Parties.

 

    	13

    	 

    

7. Miscellaneous.

 

(a) Remedies. In
the event of a breach by the Company or by a Holder of any of their obligations under this Agreement, the nonbreaching parties,
in addition to being entitled to exercise all rights granted by law and under this Agreement, including recovery of damages, will
be entitled to specific performance of their rights under this Agreement. The Company and each Holder agree that monetary
damages would not provide adequate compensation for any losses incurred by reason of a breach by it of any of the provisions
of this Agreement and hereby further agrees that, in the event of any action for specific performance in respect of such breach,
it shall waive the defense that a remedy at law would be adequate.

 

(b) No Inconsistent
Agreements. Neither the Company nor any of its subsidiaries has, as of the date hereof entered into and currently in effect,
nor shall the Company or any of its subsidiaries, on or after the date of this Agreement, enter into any agreement with respect
to its securities that is inconsistent with the rights granted to the Holders in this Agreement or otherwise conflicts with the
provisions hereof. Except as disclosed in the Schedules to the Purchase Agreement, neither the Company nor any of its subsidiaries
has previously entered into any agreement currently in effect granting any registration rights with respect to any of its securities
to any Person. Without limiting the generality of the foregoing, without the written consent of the Holders of a majority of the
then-outstanding Series B Preferred Stock, the Company shall not grant to any Person the right to request the Company to register
any securities of the Company under the Securities Act unless the rights so granted are subject in all respects to the prior rights
in full of the Holders set forth herein, and are not otherwise in conflict with the provisions of this Agreement.

 

(c) Amendments and Waivers.
The provisions of this Agreement, including the provisions of this sentence, may not be amended, modified or supplemented, and
waivers or consents to departures from the provisions hereof may not be given, unless the same shall be in writing and signed by
the Company and the Holders of 75% of the Registrable Securities outstanding (including all Registrable Securities underlying the
Preferred Shares and the Warrants); provided, that this Agreement may not be amended, and no
provision hereof may be waived, in each case, in any way which would adversely affect the rights of any Holder in a manner disproportionate
to any adverse effect such amendment or waiver would have on the rights of the other Holders, without also the written consent
of the such Holder.

 

(d) Notices. Any
notice, demand, request, waiver or other communication required or permitted to be given hereunder shall be in writing and shall
be effective (a) upon hand delivery, telecopy or facsimile at the address or number designated below (if delivered on a business
day during normal business hours where such notice is to be received), or the first business day following such delivery (if delivered
other than on a business day during normal business hours where such notice is to be received) or (b) on the second business day
following the date of mailing by express courier service, fully prepaid, addressed to such address, or upon actual receipt of such
mailing, whichever shall first occur. The addresses for such communications shall be:

    	14

    	 

    

 

	If to the Company:	
        OptimizeRx Corporation

        407 Sixth Street

        Rochester, MI 48307

        Attention: H. David Lester

        Phone: (248) 651-6558

        Fax: (248) 651-6748

         

         

	with copies (which shall not constitute notice) to:	
        Cane Clark, LLP

        3273 E. Warm Springs Rd.

        Las Vegas, NV 89120

        Attention: Scott Doney, Esq.

        Phone: (702) 312-6255

        Fax: (702) 944-7100

         

         

		
	If to Vicis:	
        Vicis Capital Master Fund

        445 Park Avenue, Suite 1901

        New York, New York 10022

        Attention: Shad Stastney

        Tel No.: (212) 909-4600

        Fax No.: (212) 909-4601

		
	with copies (which shall not constitute notice) to:	
        Quarles & Brady LLP

        411 East Wisconsin Avenue, Suite 2040

        Milwaukee, Wisconsin 53202

        Attention: Hoyt R. Stastney

        Tel No.: (414) 277-5143

        Fax No.: (414) 978-8968

Any party hereto
may from time to time change its address for notices by giving at least ten days written notice of such changed address to the
other party hereto.

 

(e) Successors and Assigns.
This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns and shall
inure to the benefit of each Holder and its successors and assigns. The Company may not assign this Agreement or any of its rights
or obligations hereunder without the prior written consent of each Holder. Vicis may assign its rights hereunder in the manner
and to the Persons as permitted under the September Purchase Agreement.

 

(f) Assignment of Registration
Rights. The rights of each Holder hereunder, including the right to have the Company register for resale Registrable Securities
in accordance with the terms of this Agreement, shall be automatically assignable by each Holder to any Person that is a transferee
or assignee of all or a portion of the Preferred Shares, the Warrants or the Registrable Securities if: (i) the Holder agrees
in writing with the transferee or assignee to assign such rights, and a copy of such agreement is furnished to the Company within
a reasonable time after such assignment, (ii) the Company is, within a reasonable time after such transfer or assignment, furnished
with written notice of (a) the name and address of such transferee or assignee, and (b) the securities with respect to which such
registration rights are being transferred or assigned, (iii) following such transfer or assignment the further disposition of such
securities by the transferee or assignees is restricted under the Securities Act and applicable state securities laws, (iv) at
or before the time the Company receives the written notice contemplated by clause (ii) of this Section, the transferee or assignee
agrees in writing with the Company to be bound by all of the provisions of this Agreement, and (v) such transfer shall have been
made in accordance with the applicable requirements of the September Purchase Agreement. The rights to assignment shall apply to
the Holders’ (and to subsequent) successors and assigns.

 

    	15

    	 

    

(g) Counterparts.
This Agreement may be executed in any number of counterparts, each of which when so executed shall be deemed to be an original
and, all of which taken together shall constitute one and the same Agreement and shall become effective when counterparts have
been signed by each party and delivered to the other parties hereto, it being understood that all parties need not sign the same
counterpart. In the event that any signature is delivered by facsimile transmission, such signature shall create a valid binding
obligation of the party executing (or on whose behalf such signature is executed) the same with the same force and effect as if
such facsimile signature were the original thereof.

 

(h) Governing
Law; Jurisdiction. This Agreement shall be governed by and construed in accordance with the internal laws of the State
of New York, without giving effect to any of the conflicts of law principles which would result in the application of the substantive
law of another jurisdiction. This Agreement shall not be interpreted or construed with any presumption against the party causing
this Agreement to be drafted. The Company and the Holders agree that venue for any dispute arising under this Agreement will lie
exclusively in the state or federal courts located in the state of New York, and the parties irrevocably waive any right to raise
forum non conveniens or any other argument that New York is not the proper venue. The Company and the Holders irrevocably
consent to personal jurisdiction in the state and federal courts of the state of New York. The Company and the Holders consent
to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address in effect
for notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and
notice thereof. Nothing in this Section 7(k) shall affect or limit any right to serve process in any other manner permitted by
law. The Company and the Holders hereby agree that the prevailing party in any suit, action or proceeding arising out of or relating
to this Agreement shall be entitled to reimbursement for reasonable legal fees from the non-prevailing party. The Company agrees
to pay all costs and expenses of enforcement of the Series B Purchase Agreement and September Purchase Agreement, and all agreements,
documents and instruments executed and/or delivered in connection therewith, including, without limitation, reasonable attorneys’
fees and expenses. The parties hereby waive all rights to a trial by jury.

 

(i) Cumulative Remedies.
The remedies provided herein are cumulative and not exclusive of any remedies provided by law.

 

(j) Severability.
If any term, provision, covenant or restriction of this Agreement is held to be invalid, illegal, void or unenforceable in any
respect, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect
and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their reasonable efforts to find and
employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision,
covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed
the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid,
illegal, void or unenforceable.

 

(k) Headings. The
headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.

    	16

    	 

    

 

(l) Shares Held by the
Company and its Affiliates. Whenever the consent or approval of Holders of a specified percentage of Registrable Securities
is required hereunder, Registrable Securities held by the Company or its Affiliates (other than any Holder or transferees or successors
or assigns thereof if such Holder is deemed to be an Affiliate solely by reason of its holdings of such Registrable Securities
and/or because of any right of such Holder to elect, designate or appoint a member or members to the Company’s board of directors)
shall not be counted in determining whether such consent or approval was given by the Holders of such required percentage.

 

(m) Amendment and Restatement
of Prior Agreement. This Agreement amends and restates in its entirety the Prior Agreement.

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

    	17

    	 

    

IN WITNESS WHEREOF, the
parties hereto have caused this Second Amended and Restated Registration Rights Agreement to be duly executed by their respective
authorized persons as of the date first indicated above.

 

	OPTIMIZERx CORPORATION
		
	By:	/s/ H. David Lester
	Name:	H. David Lester
	Title:	Chief Executive Officer
		
	HOLDERS:
		
	
        VICIS CAPITAL MASTER FUND,

        a sub-trust of Vicis Capital Series Master
        Trust

        By: Vicis Capital, LLC, its investment advisor

		
	By:	/s/ Keith W. Hughes
	Name:	Keith W. Hughes
	Title:	CFOTHIRD
AMENDED AND RESTATED SECURITY AGREEMENT

THIS THIRD AMENDED
AND RESTATED SECURITY AGREEMENT (this “Security Agreement”) is made as of September 16, 2011 by and among OptimizeRx
Corporation, a Nevada corporation (“Debtor”), and Vicis Capital Master Fund
(“Vicis”), a sub-trust of Vicis Capital Series Master Trust, a unit trust
organized and existing under the laws of the Cayman Islands, and amends and restates the 2010 Security Agreement (as defined below).

R E C I T A
L S

WHEREAS,
Debtor, Physicians Interactive, Inc., a Delaware corporation (“PI”) and Vicis are parties to that certain
Second Amended and Restated Security Agreement dated as of October 5, 2010 between Debtor, PI and Vicis (the “2010 Security
Agreement”).

WHEREAS,
pursuant to a Securities Purchase Agreement dated as of September 8, 2008, by and between Vicis and Debtor (the “Series
A Purchase Agreement”), Debtor has issued shares of Debtor’s Series A Convertible Preferred Stock, par value $.001
per share (the “Series A Preferred Shares”), to Vicis.

WHEREAS,
pursuant to a Securities Purchase Agreement dated as of June 4, 2010, by and between Debtor and Vicis (the “2010
Purchase Agreement”), Debtor has issued shares of Debtor’s Series B Convertible Preferred Stock, par value $.001
per share (the “2010 Preferred Shares”), to Vicis.

WHEREAS, pursuant
to a Securities Purchase Agreement dated October 5, 2010, by and between Debtor and PI (the “PI Purchase Agreement”),
Debtor agreed to sell and issue to PI, among other securities, a Secured Promissory Note in the principal amount of $1,000,000
(the “Note”).

WHEREAS, the obligations
of Debtor (i) to Vicis under the Series A Preferred Shares, the Series A Purchase Agreement and the other Transaction Documents
(as defined in the Series A Purchase Agreement), (ii) to Vicis under the 2010 Preferred Shares, the 2010 Purchase Agreement and
the other Transaction Documents (as defined in the 2010 Purchase Agreement, and (iii) to PI under the Note, the PI Purchase Agreement
and the other Transactional Documents (as defined in the PI Purchase Agreement) were secured by the 2010 Security Agreement.

WHEREAS, pursuant
to a Termination Agreement and Release dated September 16, 2011, by and among the Debtor, OptimizeRx Corporation, a Michigan corporation,
Vicis, Physicians Interactive Holdings, LLC, a Delaware limited liability company, and PI, the Debtor’s obligations to PI
under the Note, the PI Purchase Agreement and the other Transaction Documents (as defined in the PI Purchase Agreement) have been
terminated, and PI has released its security interest in the security and collateral securing such obligations, including without
limitation, the collateral described in the 2010 Security Agreement.

WHEREAS, pursuant
to a Securities Purchase Agreement of even date herewith, by and between Debtor and Vicis (as amended or modified from time to
time, the “2011 Purchase Agreement, and collectively with the Series A Purchase Agreement and the 2010 Purchase Agreement,
the “Purchase Agreements”), Debtor has issued shares and may issue additional shares of Debtor’s Series
B Convertible Preferred Stock (the “2011 Preferred Shares”, and collectively with the Series A Preferred Shares
and the 2010 Preferred Shares, the “Preferred Shares”) to Vicis.

    	 

    	 

    

WHEREAS, it is a
material inducement to Vicis’s execution of the 2011 Purchase Agreement and purchase of the 2011 Preferred Shares that the
Debtor and execute and deliver to Vicis this Security Agreement.

WHEREAS, this Security
Agreement is the Security Agreement referred to in the Purchase Agreements.

NOW, THEREFORE,
in consideration of the Recitals and for other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, Debtor hereby agrees with Vicis as follows:

ARTICLE
I

DEFINITIONS

Capitalized terms
not defined herein shall have the meaning given to them in the 2011 Purchase Agreement. Capitalized terms not otherwise defined
herein and defined in the UCC shall have, unless the context otherwise requires, the meanings set forth in the UCC as in effect
on the date hereof (except that the term “document” shall only have the meaning set forth in the UCC for purposes
of clause (d) of the definition of Collateral), the recitals and as follows:

1.1               
Accounts. “Accounts” shall mean all accounts, including without limitation
all rights to payment for goods sold or services rendered that are not evidenced by instruments or chattel paper, whether or not
earned by performance, and any associated rights thereto.

1.2               
Collateral. “Collateral” shall mean all personal properties and assets
of Debtor, wherever located, whether tangible or intangible, and whether now owned or hereafter acquired or arising, including
without limitation:

(a)                
all Inventory and documents relating to Inventory;

(b)                
all Accounts and documents relating to Accounts;

(c)                
all equipment, fixtures and other goods, including without limitation machinery, furniture,
vehicles and trade fixtures;

(d)                
all general intangibles (including without limitation payment intangibles, software, customer
lists, sales records and other business records, contract rights, causes of action, and licenses, permits, franchises, patents,
copyrights, trademarks, and goodwill of the business in which the trademark is used, trade names, or rights to any of the foregoing),
promissory notes, contract rights, chattel paper, documents, letter-of-credit rights and instruments;

(e)                
all motor vehicles;

(f)                 
(i) all deposit accounts and (ii) all cash and cash equivalents deposited with or delivered
to Vicis from time to time and pledged as additional security for the Obligations;

    	2

    	 

    

 

(g)                
all investment property;

(h)                
all commercial tort claims; and

(i)                  
all additions and accessions to, all spare and repair parts, special tools, equipment and
replacements for, and all supporting obligations, proceeds and products of, any and all of the foregoing assets described in Sections
(a) through (h), inclusive, above.

1.3               
Event of Default. “Event of Default” shall have the meaning specified in
the 2011 Purchase Agreement.

1.4               
Inventory. “Inventory” shall mean all inventory, including without limitation
all goods held for sale, lease or demonstration or to be furnished under contracts of service, goods leased to others, trade-ins
and repossessions, raw materials, work in process and materials used or consumed in Debtor’s business, including, without
limitation, goods in transit, wheresoever located, whether now owned or hereafter acquired by Debtor, and shall include such property
the sale or other disposition of which has given rise to Accounts and which has been returned to or repossessed or stopped in transit
by Debtor.

1.5               
Obligations. “Obligations” shall mean (a) Debtor's obligation to pay dividends
on, and redeem at the Maturity Date, the Preferred Shares as required by the terms thereof; (b) all obligations of the Debtor associated
with any renewal, extension, refinancing, or amendment to the terms of the Preferred Shares; and (c) all other debts, liabilities,
obligations, covenants and agreements of Debtor contained in the Transaction Documents.

1.6               
Person. “Person” shall mean and include an individual, partnership, corporation,
trust, unincorporated association and any unit, department or agency of government.

1.7               
Security Agreement. “Security Agreement” shall mean this Third Amended
and Restated Security Agreement, together with the schedules attached hereto, as the same may be amended, supplemented or otherwise
modified from time to time in accordance with the terms hereof.

1.8               
Security Interest. “Security Interest” shall mean the security interest
of Vicis in the Collateral granted by Debtor pursuant to this Security Agreement.

1.9               
Transaction Documents. “Transaction Documents” shall mean, as applicable,
(i) the Transaction Documents (as that term is defined in the Series A Purchase Agreement), (ii) the Transaction Documents (as
that term is defined in the 2010 Purchase Agreement), and (iii) the Transaction Documents (as that term is defined in the 2011
Purchase Agreement).

1.10           
UCC. “UCC” shall mean the Uniform Commercial Code as adopted in the State
of Nevada and in effect from time to time.

    	3

    	 

    

 

ARTICLE
II

THE SECURITY INTEREST; REPRESENTATIONS AND WARRANTIES

2.1               
The Security Interest.  To secure the full and complete payment and performance
when due (whether at maturity, by acceleration, or otherwise) of each of the Obligations, Debtor hereby grants to Vicis, its successors
and assigns, a security interest in all of Debtor’s right, title and interest in and to the Collateral.

2.2               
Representations and Warranties.  Debtor hereby represents and warrants to
Vicis that:

(a)                
The records of Debtor with respect to the Collateral are presently located only at the address(es)
listed on Schedule 1 attached to this Security Agreement.

(b)                
The Collateral is presently located only at the location(s) listed on Schedule 1
attached to this Security Agreement.

(c)                
The chief executive office and chief place(s) of business of Debtor are presently located
at the address(es) listed on Schedule 1 to this Security Agreement.

(d)                
Debtor is a Nevada corporation and its exact legal name is set forth in the definition of
“Debtor” in the introductory paragraph of this Security Agreement. The organization identification number of Debtor
is listed on Schedule 1 to this Security Agreement.

(e)                
All of Debtor’s present patents and trademarks, if any, including those which have been
registered with, or for which an application for registration has been filed in, the United States Patent and Trademark Office
are listed on Schedule 2 attached to this Security Agreement. All of Debtor’s present copyrights registered with,
or for which an application for registration has been filed in, the United States Copyright Office or any similar office or agency
of any state or any other country are listed on Schedule 2 attached to this Security Agreement.

(f)                 
Debtor has good title to, or valid leasehold interest in, all of the Collateral and there
are no Liens on any of the Collateral except Permitted Liens.

2.3               
Authorization to File Financing Statements. Debtor hereby irrevocably authorizes
Vicis at any time and from time to time to file in any UCC jurisdiction any initial financing statements and amendments thereto
that (a) indicate the Collateral (i) as all assets of Debtor or words of similar effect, regardless of whether any particular asset
comprised in the Collateral falls within the scope of Article 9 of the UCC or such other jurisdiction, or (ii) as being of an equal
or lesser scope or with greater detail, and (b) contain any other information required by Part 5 of Article 9 of the UCC for the
sufficiency of filing office acceptance of any financing statement or amendment, including whether Debtor is an organization, the
type of organization and any state or federal organization identification number issued to Debtor. Debtor agrees to furnish any
such information to Vicis promptly upon request. Debtor also ratifies its authorization for Vicis to have filed in any UCC jurisdiction
any like initial financing statements or amendments thereto if filed prior to the date hereof. 

    	4

    	 

    

 

ARTICLE
III

AGREEMENTS OF DEBTOR

From and after the
date of this Security Agreement, and until all of the Obligations are paid in full, Debtor shall:

3.1               
Sale of Collateral.  Not sell, lease, transfer or otherwise dispose of Collateral
or any interest therein, except as provided for in the Purchase Agreements and for sales of Inventory in the ordinary course of
business.

3.2               
Maintenance of Security Interest.  

(a)                
At the expense of Debtor, defend the Security Interest against any and all claims of any Person
adverse to Vicis and take such action and execute such financing statements and other documents as Vicis may from time to time
request to maintain the perfected status of the Security Interest. Debtor shall not further encumber or grant a security interest
in any of the Collateral except as provided for in the Purchase Agreements.

(b)                
Take any other action requested by Vicis to ensure the attachment, perfection and first priority
of, and the ability of Vicis to enforce its security interest in any and all of the Collateral including, without limitation, (i)
executing, delivering and, where appropriate, filing financing statements and amendments relating thereto under the UCC, to the
extent, if any, that Debtor’s signature thereon is required therefor, (ii) complying with any provision of any statute, regulation
or treaty of the United States as to any Collateral if compliance with such provision is a condition to attachment, perfection
or priority of, or ability of Vicis to enforce, its security interest in such Collateral, (iii) taking all actions required by
any earlier versions of the UCC (to the extent applicable) or by other law, as applicable in any relevant UCC jurisdiction, or
by other law as applicable in any foreign jurisdiction, and (iv) obtaining waivers from landlords where any of the tangible Collateral
is located in form and substance satisfactory to Vicis. 

3.3               
Locations.  Give Vicis at least 30 days prior written notice of Debtor’s
intention to relocate the tangible Collateral (other than Inventory in transit) or any of the records relating to the Collateral
from the locations listed on Schedule 1 attached to this Security Agreement, in which event Schedule 1 shall be deemed
amended to include the new location. Any additional filings or refilings requested by Vicis as a result of any such relocation
in order to maintain the Security Interest in the Collateral shall be at Debtor’s expense.

3.4               
Insurance.  Keep the Collateral consisting of tangible personal property
insured against loss or damage to the Collateral under a policy or policies covering such risks as are ordinarily insured against
by similar businesses, but in any event including fire, lightning, windstorm, hail, explosion, riot, riot attending a strike, civil
commotion, damage from aircraft, smoke and uniform standard extended coverage and vandalism and malicious mischief endorsements,
limited only as may be provided in the standard form of such endorsements at the time in use in the applicable state. Such insurance
shall be for amounts not less than the actual replacement cost of the Collateral. No policy of insurance shall be so written that
the proceeds thereof will produce less than the minimum coverage required by the preceding sentence, by reason of co-insurance
provisions or otherwise, without the prior consent thereto in writing by Vicis. Debtor will obtain lender’s loss payable
endorsements on applicable insurance policies in favor of Vicis and will provide certificates of such insurance to Vicis. Debtor
shall cause each insurer to agree, by endorsement on the policy or policies or certificates of insurance issued by it or by independent
instrument furnished to Vicis, that such insurer will give 30 days prior written notice to Vicis before such policy will be altered
or canceled. No settlement of any insurance claim shall be made without Vicis’s prior written consent. In the event of any
insured loss, Debtor shall promptly notify Vicis thereof in writing, and Debtor hereby authorizes and directs any insurer concerned
to make payment of such loss directly to Vicis as its interest may appear. Vicis is authorized, in the name and on behalf of Debtor,
to make proof of loss and to adjust, compromise and collect, in such manner and amounts as it shall determine, all claims under
all policies; and Debtor agrees to sign, on demand of Vicis, all receipts, vouchers, releases and other instruments which may be
necessary or desirable in aid of this authorization. The proceeds of any insurance from loss, theft, or damage to the Collateral
shall be held in a segregated account established by Vicis and disbursed and applied at the discretion of Vicis, either in reduction
of the Obligations or applied toward the repair, restoration or replacement of the Collateral. 

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3.5               
Name; Legal Status.  (a) Without providing at least 30 days prior written
notice to Vicis, Debtor will not change its name, its place of business or, if more than one, chief executive office, or its mailing
address or organizational identification number if it has one, (b) if Debtor does not have an organizational identification number
and later obtains one, Debtor shall forthwith notify Vicis of such organizational identification number, and (c) Debtor will not
change its type of organization or jurisdiction of organization.

ARTICLE
IV

RIGHTS AND REMEDIES

4.1               
Right to Cure.  In case of failure by Debtor to procure or maintain insurance,
or to pay any fees, assessments, charges or taxes arising with respect to the Collateral, Vicis shall have the right, but shall
not be obligated, to effect such insurance or pay such fees, assessments, charges or taxes, as the case may be, and, in that event,
the cost thereof shall be payable by Debtor to Vicis immediately upon demand, together with interest at an annual rate equal to
10% from the date of disbursement by Vicis to the date of payment by Debtor.

4.2               
Rights of Parties.  Upon the occurrence and during the continuance of an
Event of Default, in addition to all the rights and remedies provided in the Transaction Documents or in Article 9 of the
UCC and any other applicable law, Vicis may (but is under no obligation so to do):

(a)                
require Debtor to assemble the Collateral at a place designated by Vicis, which is reasonably
convenient to the parties; and

(b)                
take physical possession of Inventory and other tangible Collateral and of Debtor’s
records pertaining to all Collateral that are necessary to properly administer and control the Collateral or the handling and collection
of Collateral, and sell, lease or otherwise dispose of the Collateral in whole or in part, at public or private sale, on or off
the premises of Debtor; and

(c)                
collect any and all money due or to become due and enforce in Debtor’s name all rights
with respect to the Collateral; and

(d)                
settle, adjust or compromise any dispute with respect to any Account; and

(e)                
receive and open mail addressed to Debtor; and

(f)                 
on behalf of Debtor, endorse checks, notes, drafts, money orders, instruments or other evidences
of payment.

4.3               
Power of Attorney.  Upon the occurrence and during the continuance of an
Event of Default, Debtor does hereby constitute and appoint Vicis as Debtor’s true and lawful attorney with full power of
substitution for Debtor in Debtor’s name, place and stead for the purposes of performing any obligation of Debtor under this
Security Agreement and taking any action and executing any instrument which Vicis may deem necessary or advisable to perform any
obligation of Debtor under this Security Agreement, which appointment is irrevocable and coupled with an interest, and shall not
terminate until the Obligations are paid in full. 

    	6

    	 

    

 

4.4               
Right to Collect Accounts.  Upon the occurrence and during the continuance
of an Event of Default and without limiting Debtor’s obligations under the Transaction Documents: (a) Debtor authorizes Vicis
to notify any and all debtors on the Accounts to make payment directly to Vicis (or to such place as Vicis may direct); (b) Debtor
agrees, on written notice from Vicis, to deliver to Vicis promptly upon receipt thereof, in the form in which received (together
with all necessary endorsements), all payments received by Debtor on account of any Account; (c) Vicis may, at its option, apply
all such payments against the Obligations or remit all or part of such payments to Debtor; and (d) Vicis may take any actions in
accordance with Section 4.7 of this Agreement.

4.5               
Reasonable Notice.  Written notice, when required by law, sent in accordance
with the provisions of Section 5.7 and given at least ten business days (counting the day of sending) before the date of
a proposed disposition of the Collateral shall be reasonable notice.

4.6               
Limitation on Duties Regarding Collateral.  Except for the safe custody of
any Collateral in its possession and the accounting for moneys actually received by it hereunder, the sole duty of Vicis with respect
to the custody, safekeeping and physical preservation of the Collateral in its possession, under Section 9-207 of the UCC or otherwise,
shall be to deal with it in the same manner as Vicis deals with similar property for its own account. Neither Vicis nor any of
its directors, officers, employees or agents, shall be liable for failure to demand, collect or realize upon any of the Collateral
or for any delay in doing so or shall be under any obligation to sell or otherwise dispose of any Collateral upon the request of
Debtor or otherwise.

4.7               
Lock Box; Collateral Account. This Section 4.7 shall be effective only upon
the occurrence and during the continuance of an Event of Default. If Vicis so requests in writing, Debtor will direct each of its
debtors on the Accounts to make payments due under the relevant Account or chattel paper directly to a special lock box to be under
the control of Vicis. Debtor hereby authorizes and directs Vicis to deposit into a special collateral account to be established
and maintained by Vicis all checks, drafts and cash payments received in said lock box. All deposits in said collateral account
shall constitute proceeds of Collateral and shall not constitute payment of any Obligation until so applied. At its option, Vicis
may, at any time, apply finally collected funds on deposit in said collateral account to the payment of the Obligations, in the
order of application selected in the sole discretion of Vicis, or permit Debtor to withdraw all or any part of the balance on deposit
in said collateral account. If a collateral account is so established, Debtor agrees that it will promptly deliver to Vicis, for
deposit into said collateral account, all payments on Accounts and chattel paper received by it. All such payments shall be delivered
to Vicis in the form received (except for Debtor’s endorsement where necessary). Until so deposited, all payments on Accounts
and chattel paper received by Debtor shall be held in trust by Debtor for and as the property of Vicis and shall not be commingled
with any funds or property of Debtor.

4.8               
Application of Proceeds.  Vicis shall apply the proceeds resulting from any
sale or disposition of the Collateral in the following order:

(a)                
to the reasonable costs of any sale or other disposition;

    	7

    	 

    

 

(b)                
to the reasonable expenses incurred by Vicis in connection with any sale or other disposition,
including attorneys’ fees;

(c)                
to the payment to Vicis of the Obligations then due and owing in any order selected by Vicis;
and

(d)                
to Debtor.

4.9               
Other Remedies.  No remedy herein conferred upon Vicis is intended to be
exclusive of any other remedy and each and every such remedy shall be cumulative and shall be in addition to every other remedy
given under this Security Agreement and the Transaction Documents now or hereafter existing at law or in equity or by statute or
otherwise. No failure or delay on the part of Vicis in exercising any right or remedy hereunder shall operate as a waiver thereof
nor shall any single or partial exercise of any right hereunder preclude other or further exercise thereof or the exercise of any
other right or remedy.

ARTICLE
V

MISCELLANEOUS

5.1               
Expenses and Attorneys’ Fees.  Debtor shall pay all fees and expenses
incurred by Vicis, including the fees of counsel including in-house counsel, in connection with the protection, administration
and enforcement of the rights of Vicis under this Security Agreement or with respect to the Collateral, including without limitation
the protection and enforcement of such rights in any bankruptcy. 

5.2               
Setoff.  Debtor agrees that Vicis shall have all rights of setoff and bankers’
lien provided by applicable law.

5.3               
Assignability; Successors.  Debtor’s rights and liabilities under this
Security Agreement are not assignable or delegable, in whole or in part, without the prior written consent of Vicis. The provisions
of this Security Agreement shall inure to the benefit of and be binding upon the successors and assigns of the parties.

5.4               
Survival.  All agreements, representations and warranties made in this Security
Agreement or in any document delivered pursuant to this Security Agreement shall survive the execution and delivery of this Security
Agreement, and the delivery of any such document.

5.5               
Governing Law.  This Security Agreement shall be governed by, and construed
and interpreted in accordance with, the laws of the State of New York applicable to contracts made and wholly performed within
such state.

5.6               
Counterparts; Headings.  This Security Agreement may be executed in several
counterparts, each of which shall be deemed an original, but such counterparts shall together constitute but one and the same agreement.
The article and section headings in this Security Agreement are inserted for convenience of reference only and shall not constitute
a part hereof.

    	8

    	 

    

 

5.7               
Notices.  All communications or notices required or permitted by this Security
Agreement shall be given to Debtor in accordance with Section 12.6 of the 2011 Purchase Agreement.

5.8               
Amendment; No Waiver; Cumulative Remedies.  No amendment of this Security
Agreement shall be effective unless in writing and signed by Debtor and Vicis. Vicis shall not by any act (except by a written
instrument signed by Vicis), delay, indulgence, omission or otherwise be deemed to have waived any right or remedy hereunder or
to have acquiesced in any Event of Default or in any breach of any of the terms and conditions hereof. No failure to exercise,
nor any delay in exercising, on the part of Vicis, any right, power or privilege hereunder shall operate as a waiver thereof. No
single or partial exercise of any right, power or privilege hereunder shall preclude any other or further exercise thereof or the
exercise of any other right, power or privilege. A waiver by Vicis of any right or remedy hereunder on any one occasion shall not
be construed as a bar to any right or remedy which Vicis would otherwise have on any future occasion. The rights and remedies herein
provided are cumulative, may be exercised singly or concurrently and are not exclusive of any other rights or remedies provided
by law.

5.9               
Severability.  Any provision of this Security Agreement which is prohibited
or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability
without invalidating the remaining provisions of this Security Agreement in such jurisdiction or affecting the validity or enforceability
of any provision in any other jurisdiction.

5.10           
WAIVER OF RIGHT TO JURY TRIAL.   VICIS AND DEBTOR ACKNOWLEDGE AND AGREE THAT
ANY CONTROVERSY WHICH MAY ARISE UNDER THIS SECURITY AGREEMENT WOULD BE BASED UPON DIFFICULT AND COMPLEX ISSUES AND, THEREFORE,
THE PARTIES AGREE THAT ANY LAWSUIT ARISING OUT OF ANY SUCH CONTROVERSY SHALL BE TRIED IN A COURT OF COMPETENT JURISDICTION BY A
JUDGE SITTING WITHOUT A JURY.

5.11           
Submission to Jurisdiction.  As a material inducement to Vicis to execute
the 2011 Purchase Agreement and purchase the 2011 Preferred Shares:

(a)                
DEBTOR AGREES THAT ALL ACTIONS OR PROCEEDINGS IN ANY MANNER RELATING TO OR ARISING OUT OF
THIS SECURITY AGREEMENT MAY BE BROUGHT ONLY IN COURTS OF THE STATE OF NEW YORK OR THE FEDERAL COURTS LOCATED IN NEW YORK AND DEBTOR
CONSENTS TO THE JURISDICTION OF SUCH COURTS. DEBTOR WAIVES ANY OBJECTION IT MAY NOW OR HEREAFTER HAVE TO THE VENUE OF ANY SUCH
COURT AND ANY RIGHT IT MAY HAVE NOW OR HEREAFTER HAVE TO CLAIM THAT ANY SUCH ACTION OR PROCEEDING IS IN AN INCONVENIENT COURT;
AND

    	9

    	 

    

 

(b)                
Debtor consents to the service of process in any such action or proceeding by certified mail
sent to Debtor at the address specified in Section 12.6 of the 2011 Purchase Agreement.

5.12           
Effect of Amendment and Restatement. This Security Agreement amends and restates the
2010 Security Agreement and shall not be construed to be a substitution or novation of the 2010 Security Agreement.

[SIGNATURE PAGE TO
FOLLOW]

    	10

    	 

    

IN WITNESS WHEREOF,
this Third Amended and Restated Security Agreement has been executed as of the day and year first above written.

	OPTIMIZERX CORPORATION
		
	By:	/s/ H. David Lester
	Name:	H. David Lester
	Title:	CEO
		
	
        VICIS CAPITAL MASTER FUND

        By: Vicis Capital LLC

		
	By:	/s/ Keith W. Hughes
	Name:	Keith W. Hughes
	Title:	CFO

    	11

    	 

    

SCHEDULE 1 TO THIRD AMENDED AND RESTATED
SECURITY AGREEMENT

Locations of Collateral

Organizational ID:      

 

 

 

Address of Debtor’s records of Collateral
and chief executive office:

 

 

 

Collateral Locations:

 

 

 

    	12

    	 

    

SCHEDULE 2 TO THIRD AMENDED AND RESTATED
SECURITY AGREEMENT

Intellectual Property

 

 

Patents 

 

 

Trademarks 

 

 

Copyrights

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