Document:

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                                                                    Exhibit 10.1

                           AMICUS THERAPEUTICS, INC.

                           2002 EQUITY INCENTIVE PLAN

1.   Purpose.

     The purpose of this plan (the "Plan") is to secure for Amicus
Therapeutics, Inc. (the "Company") and its stockholders the benefits arising
from capital stock ownership by employees and members of the Board of Directors
of, and consultants and advisors to, the Company and any Parent Corporation, or
Subsidiary (each as defined in Section 14 hereof), who are expected to
contribute to the Company's future growth and success.

2.   Types of Awards and Administration.

     (a)  Types of Awards. Awards pursuant to this Plan shall be authorized by
action of the Board of Directors of the Company (or a Committee designated by
the Board of Directors) and may be (i) incentive stock options ("Incentive
Stock Options") to purchase shares of the Company's Common Stock, par value
$.01 per share ("Common Stock"), meeting the requirements of Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"), (ii) non-statutory
options to purchase shares of Common Stock, which are not intended to meet the
requirements of Code Section 422 ("Non-Statutory Stock Options" and, together
with Incentive Stock Options, "Options"), or (iii) shares of Common Stock
("Restricted Shares" and, together with "Options", "Awards").

     (b)  Administration. This Plan will be administered by the Board of
Directors of the Company, whose construction and interpretation of the terms
and provisions hereof shall be final and conclusive. The Board of Directors may
in its sole discretion make Awards and authorize the Company to issue shares of
Common Stock pursuant to such Awards, as provided in, and subject to the terms
and conditions of, this Plan. The Board of Directors shall have authority,
subject to the express provisions of this Plan, to construe this Plan and the
respective written agreements setting forth the terms and conditions of an
Award (each, an "Award Agreement"), to prescribe, amend and rescind rules and
regulations relating to this Plan, to determine the terms and provisions of
Award Agreements, which need not be identical, to advance the lapse of any
waiting, forfeiture or installment periods and exercise dates, and to make all
other determinations in the judgment of the Board of Directors necessary or
desirable for the administration of this Plan. The Board of Directors may
correct any defect or supply any omission or reconcile any inconsistency in
this Plan or in any Award Agreement in the manner and to the extent it shall
deem expedient to carry this Plan into effect and it shall be the sole and
final judge of such expediency. No director shall be liable for any action or
determination taken or made in good faith under or with respect to this Plan or
any Award.

     (c)  Delegation of Authority. The Board of Directors may, to the full
extent permitted by law, delegate any or all of its powers under this Plan to a
committee (the "Committee") of two or more directors, and if the Committee is
so appointed all references to the Board of Directors in this Plan shall mean
and relate to such Committee to the extent of the powers so delegated. The
Board of Directors may, from time to time, delegate to the Chief Executive
Officer authority
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under this Plan with respect to aggregate numbers of shares to permit specific
Awards by the Chief Executive Officer to employees and consultants of, and
advisors to, the Company, any Parent Corporation or any Subsidiary.

3.   Eligibility.

     Awards shall be made only to persons who are, at the time of grant,
officers, employees or directors of, or consultants or advisors to, (provided,
in the case of Incentive Stock Options, such directors or officers are then
also employees of) the Company or any Parent Corporation or Subsidiary. A
person who has been granted an Award may, if such person is otherwise eligible,
be granted an additional Award or Awards if the Board of Directors shall so
determine.

4.   Stock Subject to Plan.

     Subject to adjustment as provided in Sections 10 and 11 hereof, the
maximum number of shares of Common Stock of the Company which may be issued and
sold pursuant to Awards made under this Plan is 862,611 shares. Such shares may
be authorized and unissued shares or may be shares issued and thereafter
acquired by the Company. If either (i) Restricted Shares are forfeited
following their award under this Plan, or (ii) Options granted under this Plan
are canceled, or expire or terminate for any reason without having been
exercised in full, the forfeited Restricted Shares, or the unpurchased shares
of Common Stock subject to any such Option, as the case may be, shall again be
available for subsequent Awards under this Plan. Restricted Shares, Options and
shares of Common Stock issuable upon exercise of Options granted under this
Plan may be subject to transfer restrictions, repurchase rights or other
restrictions as shall be determined by the Board of Directors.

5.   Award Agreements.

     As a condition to the grant of an Award under this Plan, each recipient of
an Award shall sign an Award Agreement not inconsistent with this Plan in such
form, and providing for such terms and conditions, as the Board of Directors
shall determine at the time such Award is authorized to be granted. Such Award
Agreements need not be identical but shall comply with, and be subject to, the
terms and conditions set forth herein.

6.   Options Generally.

     (a)  Purchase Price. The purchase price per share of Common Stock
deliverable upon the exercise of (i) a Non-Statutory Stock Option may be less
than the fair market value of the Common Stock, and (ii) an Incentive Stock
Option may not be less than the fair market value of the Common Stock, as such
purchase price is determined by the Board of Directors on the date such Option
is authorized to be granted; provided, that in the event that the Common Stock
of the Company becomes registered under the Securities Exchange Act of 1934, as
amended (the "Exchange Act") and is publicly traded ("Publicly Traded"), the
fair market value of the Common Stock shall be equal to the closing price of
the Common Stock on the date such Option is authorized to be granted.

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     (b)  Payment of Exercise Price. Payment of the exercise price of an Option
shall be in cash or, in the sole discretion of the Board of Directors, in shares
of capital stock of the Company held by the Option holder for greater than six
months, or by any other lawful means. The Company may, in its sole discretion,
make loans to an Option holder in an amount equal to all or part of the exercise
price of Options held by such Option holder which such loans may be secured or
unsecured, as agreed upon between the parties at such time; provided, that the
grant of a loan on any occasion to one or more Option holder(s) shall not
obligate the Company to grant loans on any other occasion or to such or any
other Option holder.

     (c)  Option Term. Each Option and all rights thereunder shall expire on
such date as the Board of Directors shall determine on the date such Option is
authorized to be granted, but in no event may any Option remain in effect after
the expiration of ten years from the day on which such Option is granted (or
five years in the case of Options described in paragraph (b) of Section 7
hereof), and such Option shall be subject to earlier termination as provided in
this Plan.

     (d)  Exercise of Options. Each Option shall be exercisable either in full
or in installments at such time or times and during such period as shall be set
forth in the Award Agreement evidencing such Option; provided, however, that,
(i) no Option shall have a term in excess of ten years from the date of grant
(or five years in the case of Options described in paragraph (b) of Section 7
hereof), and (ii) the periods of time following an Option holder's cessation of
employment with the Company, any Parent Corporation or Subsidiary, or service as
a consultant or advisor to the Company, any Parent Corporation or Subsidiary, or
following an Option holder's death or disability, during which an Option may be
exercised, as provided in paragraph (f) below, shall not be included for
purposes of determining the number of shares of Common Stock with respect to
which such Option may be exercised.

     (e)  Rights as a Stockholder. The holder of an Option shall have no rights
as a stockholder with respect to any shares covered by the Option until the date
of issue of a stock certificate to such person for such shares. Except as
otherwise expressly provided in the Plan, no adjustment shall be made for
dividends or other rights for which the record date is prior to the date such
stock certificate is issued.

     (f)  Effect of Cessation of Service. Notwithstanding anything contained in
this Plan to the contrary, no Option may be exercised unless, at the time of
such exercise, the recipient is, and has been continuously since the date of
grant of such recipient's Option, employed by or serving as a director,
consultant or an advisor to, one or more of the Company, a Parent Corporation or
a Subsidiary, except if and to the extent the applicable Award Agreement
provides otherwise (other than with respect to an Incentive Stock Option for
which Section 7 hereof shall apply); provided, however, that in no event may any
Option be exercised after the expiration date of the Option.

     (g)  Transfer Restrictions. Except as otherwise approved by the Board of
Directors, during the life of the holder thereof an Option shall be exercisable
only by or on behalf of such person and no Option granted under the Plan shall
be assignable or transferable by the person to whom it is granted, either
voluntarily or by operation of law, except by will or the laws of descent and
distribution.

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     (h) Other Awards. Awards of Options may be made alone, in addition to or in
tandem with Awards of Restricted Shares under the Plan.

7.   Incentive Stock Options.

     Options granted under the Plan which are intended to be Incentive Stock
Options shall be specifically designated as Incentive Stock Options and shall be
subject to the following additional terms and conditions:

     (a)  Dollar Limitation. The aggregate fair market value (determined as of
the respective date or dates of the grant) of the Common Stock with respect to
which Incentive Stock Options granted to any employee under the Plan (and under
any other incentive stock option plans of the Company, and any Parent
Corporation and Subsidiary) are exercisable for the first time shall not exceed
$100,000 in any one calendar year. In the event that Section 422 of the Code is
amended to alter the limitation set forth therein so that following such
amendment such limitation shall differ from the limitation set forth in this
paragraph (a), the limitation of this paragraph (a) shall be automatically
adjusted accordingly.

     (b)  10% Stockholder. If any employee to whom an Incentive Stock Option is
to be granted under the Plan is at the time of the grant of such Option the
owner of stock possessing more than 10% of the total combined voting power of
all classes of stock of the Company or of any Parent Corporation or any
Subsidiary, then the following special provisions shall be applicable to the
Incentive Stock Option granted to such individual:

          (i)  the purchase price per share of Common Stock subject to such
     Incentive Stock Option shall not be less than 110% of the fair market value
     thereof at the time of grant; and

          (ii) the exercise period of such Incentive Stock Option shall not
     exceed five years from the date of grant.

Except as modified by the preceding provisions of this Section 7, all the
provisions of the Plan applicable to Options generally shall be applicable to
Incentive Stock Options granted hereunder.

     (c)  Effect of Cessation of Service. No Incentive Stock Option may be
exercised unless, at the time of such exercise, the holder of such Option is,
and has been continuously since the date of grant of such Incentive Stock
Option, employed by one or more of the Company, a Parent Corporation or
Subsidiary, except that if and to the extent the Award Agreement so provides:

          (i)  the Option may be exercised within the period of three months
     after the date the holder of an Option ceases to be employed by the
     Company, a Parent Corporation or a Subsidiary (or within such lesser period
     as may be specified in the Award Agreement) for any reason other than death
     or disability;

          (ii) if the holder of an Option dies while in the employ of the
     Company, a Parent Corporation or a Subsidiary or within three months after
     such holder ceases to be such an employee, the Option may be exercised by
     the person to whom it is transferred

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     by will or the laws of descent and distribution within the period of one
     year after the date of death (or within such lesser period as may be
     specified in the Award Agreement); and

          (iii) if the holder of an Option becomes disabled (within the meaning
     of Section 22(e)(3) of the Code) while in the employ of the Company, a
     Parent Corporation or a Subsidiary, the Option may be exercised within the
     period of one year after the date the holder ceases to be an employee of
     any of the foregoing entities because of such disability (or within such
     lesser period as may be specified in the option agreement or instrument);

Except as modified by the preceding provisions of this Section 7, all the
provisions of the Plan shall be applicable to Incentive Stock Options granted
hereunder.

8.   Restricted Shares.

     (a)  Awards of Shares. Awards of Restricted Shares may be made under this
Plan on such terms and conditions as the Board of Directors may from time to
time approve. Awards of Restricted Shares may be made alone, in addition to or
in tandem with Awards of Options under this Plan. Subject to the terms of this
Plan, the Board of Directors shall determine the number of Restricted Shares to
be awarded to each recipient and the Board of Directors may impose different
terms and conditions on a Restricted Share Award than on any other Award made to
the same recipient or other Award recipients. Each recipient of Restricted
Shares shall, except in the circumstances described in paragraph (b) below, be
issued one or more stock certificates evidencing such Restricted Shares. Each
such certificate shall be registered in the name of such recipient, and shall
bear an appropriate legend referring to the terms and conditions applicable to
the Restricted Shares evidenced thereby.

     (b)  Forfeiture of Restricted Shares. In making an Award of Restricted
Shares, the Board of Directors may impose a requirement that the recipient must
remain in the employment or service (including service as an advisor or
consultant) of the Company or any Parent Corporation or Subsidiary for a
specified minimum period of time, or else forfeit all or a portion of such
Restricted Shares. In the case of a holder of Restricted Shares whose
relationship with the Company or any Parent Corporation or Subsidiary changes
during the term of any applicable forfeiture period in a manner that does not
constitute a complete separation therefrom (for example, from employee to
consultant or director, or vise versa), the Board of Directors shall have
authority to determine whether or not such change constitutes a cessation of
employment or service for purposes of such requirement. In such case, the
certificate(s) evidencing the Restricted Shares shall be held in custody by the
Company until such Shares are no longer subject to forfeiture.

     (c)  Rights as a Stockholder; Stock Dividends. Subject to any restrictions
set forth in the applicable Award Agreement, a recipient of Restricted Shares
shall have voting, dividend and all other rights of a stockholder of the Company
as of the date such Shares are issued and registered in recipient's name
(whether or not certificates evidencing such Shares are delivered to such
recipient). Except as may otherwise be set forth in the applicable Award
Agreement, stock dividends issued with respect to Restricted Shares shall be
treated as additional Restricted

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Shares under the applicable Award Agreement and shall be subject to the same
terms and conditions that apply to the Restricted Shares with respect to which
such dividends are issued.

9.   General Award Restrictions.

     (a)  Investment Representations. The Company may require any person to
whom an Award is made, as a condition of such Award, to give written assurances
in substance and form satisfactory to the Company to the effect that such
person is acquiring the Common Stock subject to the Award for such person's own
account for investment and not with any present intention of selling or
otherwise distributing the same, and to such other effects as the Company deems
necessary or appropriate in order to comply with applicable Federal and State
securities laws.

     (b)  Special Conditions to Issuance of Shares. Each Award shall be subject
to the requirement that, if at any time counsel to the Company shall determine
that the listing, registration or qualification of the shares of Common Stock
subject to such Award upon any securities exchange or under any State or
Federal law, or the consent or approval of any governmental or regulatory body,
is necessary as a condition of, or in connection with, the issuance or purchase
of such shares thereunder, such shares may not be issued unless such listing,
registration, qualification, consent or approval shall have been effected or
obtained on conditions acceptable to the Board of Directors. Nothing herein
shall be deemed to require the Company to apply for or to obtain such listing,
registration or qualification.

10.  Recapitalization.

     In the event that the outstanding shares of Common Stock of the Company
are changed into or exchanged for a different number or kind of shares or other
securities of the Company by reason of any recapitalization, reclassification,
stock split, stock dividend, combination or subdivision, appropriate adjustment
shall be made in the number and kind of shares available under this Plan and
under any Options granted under this Plan. Such adjustment to outstanding
Options shall be made without change in the total exercise price applicable to
the unexercised portion of such Options, but a corresponding adjustment in the
applicable Option exercise price per share shall be made. No such adjustment
shall be made which would, within the meaning of any applicable provisions of
the Code, constitute a modification, extension or renewal of any Option or a
grant of additional benefits to the holder of an Option.

11.  Reorganization of the Company.

     In case (i) of any consolidation or merger involving the Company if the
shareholders of the Company immediately before such merger or consolidation do
not own, directly or indirectly, immediately following such merger or
consolidation, more than fifty percent (50%) of the combined voting power of
the outstanding voting securities of the corporation resulting from such merger
or consolidation in substantially the same proportion as their ownership of the
outstanding voting securities of the Company immediately before such merger or
consolidation; (ii) of any sale, lease, license, exchange or other transfer (in
one transaction or a series of related transactions) of all, or substantially
all, of the business and/or assets of the Company; or (iii) any person (as such
term is used in Sections 13(d) and 14(d) of the Exchange Act) shall become

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(x) the beneficial owner (within the meaning of Rule 13d-3 under the Exchange
Act) of over 50% of the combined voting power of the Company's then outstanding
voting securities entitled to vote generally or (y) a "controlling person" (as
defined in Rule 405 under the Securities Act of 1933, as amended) (a
"Controlling Person") of the Company (each of the events described in the
foregoing clauses (i), (ii) and (iii), a "Reorganization Event"), the Board of
Directors of the Company, or the board of directors of any corporation assuming
the obligations of the Company, shall, as to outstanding Options, either (x)
make appropriate provision for the protection of any such outstanding Options
by the substitution on an equitable basis of appropriate stock of the Company,
or of the merged, consolidated or otherwise reorganized corporation which will
be issuable in respect of the shares of Common Stock of the Company, provided
that no additional benefits shall be conferred upon holders of Options as a
result of such substitution, and the excess of the aggregate fair market value
of the shares subject to any Option immediately after such substitution over
the purchase price thereof is not more than the excess of the aggregate fair
market value of the shares subject to such Option immediately before such
substitution over the purchase price thereof, or (y) upon written notice to the
holders of Options, provide that all unexercised Options must be exercised
within a specified number of days of the date of such notice or they will be
terminated. In any such case, the Board of Directors may, in its discretion,
accelerate the exercise dates of outstanding Options, and the vesting dates of
any Restricted Shares subject to forfeiture.

12. No Special Employment Rights.

     Nothing contained in this Plan or in any Award Agreement shall confer upon
any Award recipient any right with respect to the continuation of such person's
employment by the Company (or any Parent Corporation or Subsidiary) or
interfere in any way with the right of the Company (or any Parent Corporation
or Subsidiary), subject to the terms of any separate agreement to the contrary,
at any time to terminate such employment or to increase or decrease the
compensation of the Award recipient from the rate in existence at the time of
the Award. Whether an authorized leave of absence, or absence in military or
government service, shall constitute termination or cessation of employment for
purposes of this Plan or any Award shall be determined by the Board of
Directors.

13. Other Employee Benefits.

     The amount of any compensation deemed to be received by an employee as a
result of any Award (including the exercise of an Option, or the sale of shares
of Common Stock received upon such exercise or of Restricted Shares) will not
constitute "earnings" with respect to which any other employee benefits of such
employee are determined, including without limitation benefits under any
pension, profit sharing, life insurance or salary continuation plan.

14. Definitions.

     (a)  Subsidiary. The term "Subsidiary" as used in this Plan shall mean any
corporation in an unbroken chain of corporations beginning with the Company if
each of the corporations other than the last corporation in the unbroken chain
owns stock possessing 50% or more of the total combined voting power of all
classes of stock in one of the other corporations in such chain. For purposes
only of Awards of Non-Statutory Options or Restricted Shares, the

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term "Subsidiary" shall also mean any partnership or limited partnership of
which the Company or any Subsidiary controls 50% or more of the voting power, or
any corporation in an unbroken chain of Subsidiaries if each of the Subsidiaries
other than the last Subsidiary in the unbroken chain either owns stock
possessing 50% or more of the total combined voting power of all classes of
stock in one of the other corporations or controls 50% or more of the voting
power of any such partnership or limited partnership in such chain.

     (b)  Parent Corporation. The term "Parent Corporation" as used in this Plan
shall mean any corporation (other than the Company) in an unbroken chain of
corporations ending with the Company if each of the corporations other than the
Company owns stock possessing 50% or more of the combined voting power of all
classes of stock in one of the other corporations in such chain.

     (c)  Employment. The term "employment", as used in this Plan and in any
Award Agreement, shall, unless the context otherwise requires, be defined in
accordance with the provisions of Section 1.421-7(h) of the Federal Income Tax
Regulations (or any successor regulations).

15.  Amendment of this Plan.

     The Board of Directors may at any time and from time to time modify, amend
or terminate this Plan in any respect, except to the extent stockholder approval
is required by law. The termination or any modification or amendment of this
Plan shall not, without the consent of an Award recipient, adversely affect such
Award recipient's rights under any Award Agreement unless such Agreement so
specifies. With the consent of the Award recipient affected, the Board of
Directors may amend outstanding Award Agreements in a manner not inconsistent
with this Plan. The Board of Directors shall have the right to amend or modify
the terms and provisions of this Plan and of any outstanding Incentive Stock
Options granted under this Plan to the extent necessary to qualify any or all
such Options for such favorable Federal income tax treatment (including deferral
of taxation upon exercise) as may be afforded incentive stock options under
Section 422 of the Code.

16.  Withholding.

     The Company's obligation to deliver Restricted Shares awarded, or shares
deliverable upon the exercise of any Option granted, under this Plan shall be
subject to the Award recipient's satisfaction of all applicable Federal, State
and local income and employment tax withholding requirements, and the Award
recipient shall elect to withhold only the minimum statutory taxes.

17.  Duration of this Plan.

     Unless earlier terminated by the Board of Directors, this Plan shall
terminate upon the earlier of (i) the close of business on April 22, 2012 or
(ii) the date on which all shares available for issuance under this Plan shall
have been issued as Restricted Shares or pursuant to the exercise of Options
granted under this Plan and/or are no longer subject to forfeiture pursuant to
the terms of any applicable Award Agreement. If the date of termination is
determined under

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(i) above, then Awards outstanding on such date shall continue to have force and
effect in accordance with the provisions of the Award Agreements evidencing such
Awards.

                                        Adopted on April 22, 2002 by the
                                        Board of Directors and approved by
                                        stockholders on July 30, 2002.

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THE FOLLOWING RESOLUTIONS WERE ADOPTED AT A MEETING OF THE BOARD OF DIRECTORS OF
AMICUS THERAPEUTICS, INC. ON FEBRUARY 28, 2006:

Stock Option Plan

     RESOLVED, that the Company's 2002 Equity Incentive Plan (the "Plan") be
amended by increasing the number of shares of Common Stock issuable under the
Plan to employees, officers, directors, consultants and agents of the Company to
17,500,000 shares; and be it further

     RESOLVED, that the Company hereby reserve a total of 17,500,000 shares of
Common Stock for issuance under the Plan; and be it further
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                          AMICUS THERAPEUTICS, INC.

                                 AMENDMENT TO
                          2002 EQUITY INCENTIVE PLAN

                                 AUGUST 2006

      The 2002 Equity Incentive Plan of Amicus Therapeutics, Inc., as amended
(the "Plan"), shall be further amended as set forth herein. Except to the extent
specifically amended as set forth herein, the Plan shall remain in full force
and effect. All capitalized terms used herein without definition shall have the
definitions for such terms as set forth in the Plan.

      1.    Section 3 of the Plan is amended by adding the following sentence at
the end of the paragraph:

            "Further, in no event shall the number of shares of Common Stock
            covered by Awards granted to any one person in any one calendar year
            (or portion of a year) ending after such date exceed twenty-five
            percent (25%) of the aggregate number of shares of Common Stock
            subject to this Plan."

      2.    As amended in February 2006, the first sentence of Section 4 of the
Plan now reads as follows (based upon the capitalization of the Company as of
May 8, 2006):

            "Subject to adjustment as provided in Sections 10 and 11 hereof, the
            maximum number of shares of Common Stock of the Company which may be
            issued and sold pursuant to Awards (including pursuant to Incentive
            Stock Options) made under this Plan is 17,500,000 shares." (emphasis
            added)

      3.    Section 6 of the Plan is amended by adding the following phrase at
the end of the last sentence thereof:

            "or, if no closing price is reported for that date, the closing
            price on the next preceding date for which a closing price was
            reported."

      4.    Section 9 of the Plan is amended by adding the following provisions
after subsection (b) thereof:

            "(c) Violation of Law. Notwithstanding any other provision of the
            Plan or the relevant Award Agreement, if, at any time, in the
            reasonable opinion of the Company, the issuance of shares of Common
            Stock covered by an Award may constitute a violation of law, then
            the Company may delay such issuance and the delivery of a
            certificate for such shares until (i) approval shall have been
            obtained from such governmental agencies, other than the Securities
            and Exchange Commission, as may be required under any applicable
            law, rule, or regulation and (ii) in the case where such issuance
            would constitute a violation of a law

<PAGE>

            administered by or a regulation of the Securities and Exchange
            Commission, one of the following conditions shall have been
            satisfied:

                  (A) the shares are at the time of the issue of such shares
                  effectively registered under the Securities Act; or

                  (B) the Company shall have determined, on such basis as it
                  deems appropriate (including an opinion of counsel in form and
                  substance satisfactory to the Company) that the sale,
                  transfer, assignment, pledge, encumbrance or other disposition
                  of such shares or such beneficial interest, as the case may
                  be, does not require registration under the Securities Act or
                  any applicable state securities laws.

            (d) Corporate Restrictions on Rights in Stock. Any Common Stock to
            be issued pursuant to Awards granted under the Plan shall be subject
            to all restrictions upon the transfer thereof which may be now or
            hereafter imposed by the Certificate of Incorporation and the
            By-laws of the Company, each as amended and in effect from time to
            time. Whenever Common Stock is to be issued pursuant to an Award, if
            the Committee so directs at the time of grant (or, if such Award is
            an Option, at any time prior to the exercise thereof), the Company
            shall be under no obligation, notwithstanding any other provision of
            the Plan or the relevant Award Agreement to the contrary, to issue
            such shares until such time, if ever, as the recipient of the Award
            (and any person who exercises any Option, in whole or in part),
            shall have become a party to and bound by any agreement that the
            Committee shall require in its sole discretion. In addition, any
            Common Stock to be issued pursuant to Awards granted under the Plan
            shall be subject to all stop-transfer orders and other restrictions
            as the Committee may deem advisable under the rules, regulations and
            other requirements of any stock exchange upon which the Common Stock
            is then listed, and any applicable federal or state securities laws,
            and the Committee may cause a legend or legends to be put on any
            such certificates to make appropriate reference to such
            restrictions.

            (e) Investment Representations. The Company shall be under no
            obligation to issue any shares covered by an Award unless the shares
            to be issued pursuant to Awards granted under the Plan have been
            effectively registered under the Securities Act or the holder of
            such Award shall have made such written representations to the
            Company (upon which the Company believes it may reasonably rely) as
            the Company may deem necessary or appropriate for purposes of
            confirming that the issuance of such shares will be exempt from the
            registration requirements of that Act and any applicable state
            securities laws and otherwise in compliance with all applicable
            laws, rules and regulations, including but not limited to that the
            holder of such Award is acquiring shares for his or her own account
            for the purpose of investment and not with a view to, or for sale in
            connection with, the distribution of any such shares.

            (f) Registration. If the Company shall deem it necessary or
            desirable to register under the Securities Act or other applicable
            statutes any shares of Common Stock issued or to be issued pursuant
            to Awards granted under the Plan, or to qualify any such shares of
            Common Stock for exemption from the Securities Act or other
            applicable statutes, then the Company shall take such action at its
            own expense. The Company may require from each recipient of an
<PAGE>
            Award, or each holder of shares of Common Stock acquired pursuant to
            the Plan, such information in writing for use in any registration
            statement, prospectus, preliminary prospectus or offering circular
            as is reasonably necessary for such purpose and may require
            reasonable indemnity to the Company and its officers and directors
            from such holder against all losses, claims, damage and liabilities
            arising from such use of the information so furnished and caused by
            any untrue statement of any material fact therein or caused by the
            omission to state a material fact required to be stated therein or
            necessary to make the statements therein not misleading in the light
            of the circumstances under which they were made.

            (g) Lock-Up. Without the prior written consent of the Company or the
            managing underwriter in any public offering of shares of Common
            Stock, no holder of an Award shall sell, make any short sale of,
            loan, grant any option for the purchase of, pledge or otherwise
            encumber, or otherwise dispose of, any shares of Common Stock during
            the one hundred-eighty (180) day period commencing on the effective
            date of the registration statement relating to any underwritten
            public offering of securities of the Company. The foregoing
            restrictions are intended and shall be construed so as to preclude
            any holder of an Award from engaging in any hedging or other
            transaction that is designed to or reasonably could be expected to
            lead to or result in, a sale or disposition of any shares of Common
            Stock during such period even if such shares of Common Stock are or
            would be disposed of by someone other than such holder. Such
            prohibited hedging or other transactions would include, without
            limitation, any short sale (whether or not against the box) or any
            purchase, sale or grant of any right (including without limitation
            any put or call option) with respect to any shares of Common Stock
            or with respect to any security that includes, relates to, or
            derives any significant part of its value from any shares of Common
            Stock. Without limiting the generality of the foregoing provisions
            of this Section 9.5, if, in connection with any underwritten public
            offering of securities of the Company, the managing underwriter of
            such offering requires that the Company's directors and officers
            enter into a lock-up agreement containing provisions that are more
            restrictive than the provisions set forth in the preceding sentence,
            then (a) each holder (regardless of whether or not such holder has
            complied or complies with the provisions of clause (b) below) shall
            be bound by, and shall be deemed to have agreed to, the same lock-up
            terms as those to which the Company's directors and officers are
            required to adhere; and (b) at the request of the Company or such
            managing underwriter, each holder shall execute and deliver a
            lock-up agreement in form and substance equivalent to that which is
            required to be executed by the Company's directors and officers.

            (h) Placement of Legends; Stop Orders; Etc. Each share of Common
            Stock to be issued pursuant to Awards granted under the Plan may
            bear a reference to the investment representations made in
            accordance with Section 9.3 in addition to any other applicable
            restrictions under the Plan, the terms of the Award and, if
            applicable, under any agreement between the Company and any Optionee
            and/or holder, and to the fact that no registration statement has
            been filed with the Securities and Exchange Commission in respect to
            such shares of Common Stock. All certificates for shares of Common
            Stock or other securities delivered under the Plan shall be subject
            to such stock transfer orders and other restrictions as the
            Committee may deem advisable under the rules, regulations, and other
<PAGE>
            requirements of any stock exchange upon which the Common Stock is
            then listed, and any applicable federal or state securities law, and
            the Committee may cause a legend or legends to be placed on any such
            certificates to make appropriate reference to such restrictions.

            (i) Tax Withholding. Whenever shares of Common Stock are issued or
            to be issued pursuant to Awards granted under the Plan, the Company
            shall have the right to require the recipient to remit to the
            Company an amount sufficient to satisfy federal, state, local or
            other withholding tax requirements if, when, and to the extent
            required by law (whether so required to secure for the Company an
            otherwise available tax deduction or otherwise) prior to the
            delivery of any certificate or certificates for such shares. The
            obligations of the Company under the Plan shall be conditional on
            satisfaction of all such withholding obligations and the Company
            shall, to the extent permitted by law, have the right to deduct any
            such taxes from any payment of any kind otherwise due to the
            recipient of an Award. However, in such cases holders may elect,
            subject to approval of the Committee, acting in its sole discretion,
            to satisfy an applicable withholding requirement, in whole or in
            part, by having the Company withhold shares to satisfy their tax
            obligations.

      5.    Section 15 of the Plan is amended by adding the following sentence
after the second sentence thereof:

            "Subject to the foregoing, this Plan may be terminated, amended or
            modified by the board of directors, and such termination, amendment
            and/or modification shall apply to and govern each then outstanding
            Award under this Plan."

<PAGE>

THE FOLLOWING RESOLUTIONS WERE ADOPTED BY WRITTEN CONSENT OF THE BOARD OF
DIRECTORS OF AMICUS THERAPEUTICS, INC. ON SEPTEMBER 13, 2006:

                   Amendment of 2002 Equity Incentive Plan

            RESOLVED, that effective upon the initial closing of the
transactions contemplated by the Transaction Documents (the "Initial Closing"),
the 2002 Equity Incentive Plan (the "Plan") is hereby amended to increase the
number of shares of Common Stock available for issuance thereunder to 20,500,000
shares of Common Stock; and be it further

            RESOLVED, that the Designated Officers be, and each hereby is,
authorized and directed to solicit and obtain the approval of the stockholders
to such amendment of the Plan, and to take such further actions as are necessary
to effect the amendment to the Plan; and be it further

            RESOLVED, that the Company hereby reserves a total of 20,500,000
shares of Common Stock for issuance under the Plan; and be it further

<PAGE>

                            AMICUS THERAPEUTICS, INC.

                                FOURTH AMENDMENT
                                       TO
                           2002 EQUITY INCENTIVE PLAN

            This Fourth Amendment ("Fourth Amendment") to the 2002 Equity
Incentive Plan (the "Plan") of Amicus Therapeutics, Inc., a Delaware corporation
(the "Company"), was adopted at by the Board of Directors of the Company at a
meeting on April 25, 2007 and shall be effective as of April 25, 2007.

            1. AMENDMENT TO SECTION 4 OF THE PLAN.

            Section 4 of the Plan is hereby amended by deleting the number
"20,500,000" appearing in the first sentence thereof and substituting in lieu
thereof the number "23,760,000."

            2. RATIFICATION, ETC.

            Except as expressly set forth above, all of the terms, provisions
and conditions of the Plan are hereby ratified and confirmed and shall remain in
full force and effect and all references to the Plan shall hereinafter be deemed
to be references to the Plan as amended by this Fourth Amendment.

                                      * * *
<PAGE>
                            AMICUS THERAPEUTICS, INC.

                        INCENTIVE STOCK OPTION AGREEMENT

      1.    Grant of Option.  Amicus Therapeutics, Inc., a Delaware
corporation (the "Company"), hereby grants to _______________ (the
"Associate"), an option (the "Option"), pursuant to the Company's 2002 Equity
Incentive Plan (the "Plan"), to purchase up to an aggregate of _________ (the
"Shares") of Common Stock, $0.01 par value ("Common Stock"), of the Company
at a price of $_______ per Share (the "Exercise Price"), purchasable as set
forth in and subject to the terms and conditions of this Agreement and the
Plan.

      2.    Incentive Stock Option.  The Option is intended to qualify as an
incentive stock option ("Incentive Stock Option") within the meaning of
Section 422 of the Internal Revenue Code of 1986, as amended (the "Code").

      3.    Exercise of Option and Provisions for Termination.

            (a) Exercisability of Option. The Option shall become exercisable as
follows: _____ shares shall vest and become exercisable on the first anniversary
(the "Anniversary Date") of the Associate's initial date of employment as set
forth on the signature page hereof. The remaining shares shall vest and become
exercisable in equal monthly installments of ____ shares on the first day of
each of the next 35 calendar months, beginning on the first day of the calendar
month next following the Anniversary Date, and ______ shares shall vest and
become exercisable on _________, 201_. The periods of time following the
Associate's cessation of service, death or disability, during which the Option
remains outstanding as provided in subsections (e) and (f) below, shall not be
included for purposes of determining the exercisability of the Option under this
subsection (a).

            (b) Expiration Date. Except as otherwise provided in this Agreement,
the Option may not be exercised after the date (hereinafter the "Expiration
Date") that is the tenth anniversary of the date of grant set forth on the
signature page hereof (the "Date of Grant") or, if the Associate is a "10%
Shareholder" as described in Section 11(b) of the Plan, the fifth anniversary of
the Date of Grant.

            (c) Exercise Procedure. Subject to the conditions set forth in this
Agreement, the Option shall be exercised by the Associate's delivery of written
notice of exercise to the Company's Vice President of Human Resources and
Leadership

<PAGE>

Development (the "VP HR"), specifying the number of Shares to be purchased and
the aggregate Exercise Price to be paid therefor, accompanied by payment in full
in accordance with Section 4. Such exercise shall be effective upon receipt by
the VP HR of such written notice together with the required payment. The
Associate may purchase less than the total number of Shares covered hereby,
provided that no partial exercise of the Option may be for any fractional Share
or for less than ten whole Shares.

            (d) Continuous Employment Required. Except as otherwise provided in
this Section 3, the Option may not be exercised unless the Associate, at the
time he or she exercises the Option, is, and has been at all times since the
Date of Grant of the Option, an employee of one or more of the Company, a Parent
Corporation or a Subsidiary (as such terms are defined in the Plan). For all
purposes of this Agreement, (i) "employment" shall be defined in accordance with
the provisions of Section 1.421-7(h) of the Income Tax Regulations or any
successor regulations, and (ii) if the Option shall be assumed or a new option
substituted therefor in a transaction to which Section 424(a) of the Code
applies, employment by such assuming or substituting corporation (hereinafter
called the "Successor Corporation") or by a Parent Corporation or a Subsidiary
thereof (as defined in the Plan, respectively, but with the Successor
Corporation substituted for the Company in such definitions) shall be considered
for all purposes of this Agreement to be employment by the Company, a Parent
Corporation or a Subsidiary, as the case may be.

            (e) Termination of Employment. If the Associate ceases to be
employed by the Company, a Parent Corporation or Subsidiary for any reason other
than death or disability or a discharge for "cause", the right to exercise the
Option shall terminate three months after such cessation (but in no event after
the Expiration Date).

            (f) Exercise Period Upon Death or Disability. If the Associate dies
or becomes disabled (within the meaning of Section 22(e) (3) of the Code) prior
to the Expiration Date, while he or she is an employee of the Company, a Parent
Corporation or a Subsidiary, or if the Associate dies within three months after
the Associate ceases to be an employee of any of the foregoing entities (other
than as the result of a discharge for "cause" as specified in subsection (g)
below), the Option shall be exercisable, within the period of one year following
the date of death or disability of the Associate (but in no event after the
Expiration Date), by the Associate, the Associate's legal representative (in the
event of legal incapacity) or by the person to whom the Option is transferred by
will or the laws of descent and distribution. Except as otherwise indicated by
the context, the term "Associate", as used in this Agreement, shall be deemed to
include the estate of the Associate, or any person who acquirers the right to
exercise the Option by bequest or inheritance or otherwise by reason of the
death of the Associate.

            (g) Discharge for Cause. If the Associate, prior to the Expiration
Date, ceases his or her employment with the Company, a Parent Corporation or a
Subsidiary because he or she is discharged for "cause" (as defined below), the
right to exercise the

<PAGE>

Option shall terminate immediately upon such cessation of employment. "Cause"
shall mean willful misconduct in connection with the Associate's employment or
willful failure to perform his or her employment responsibilities in the best
interests of his or her employer, as determined by the Company, which
determination shall be conclusive.

      4.    Payment of Exercise Price.  Payment of the aggregate Exercise
Price for Shares purchased upon exercise of the Option shall be made by
delivery to the Company of cash or a check to the order of the Company.

      5. Delivery of Shares. The Company shall, upon payment of the aggregate
Exercise Price for the number of Shares purchased and paid for, make prompt
delivery of such Shares to the Associate, provided that if any law or regulation
requires the Company to take any action with respect to such Shares before the
issuance thereof, then the date of delivery of such Shares shall be extended for
the period necessary to complete such action. No Shares shall be issued and
delivered upon exercise of the Option unless and until, in the opinion of
counsel for the Company, any applicable registration requirements of the
Securities Act of 1933, as amended (the "Securities Act"), any applicable
listing requirements of any national securities exchange on which stock of the
same class is then listed, and any other requirements of law or of any
regulatory bodies having jurisdiction over such issuance and delivery, shall
have been fully complied with.

      6. Non-transferability of Option. Except as provided in subsection (f) of
Section 3, or as otherwise agreed to by the Board of Directors or the
Compensation Committee of the Board of Directors, the Option is personal and no
rights granted hereunder may be transferred, assigned, pledged or hypothecated
in any way (whether by operation of law or otherwise) nor shall any such rights
be subject to execution, attachment or similar process. Upon any attempt to
transfer, assign, pledge, hypothecate or otherwise dispose of the Option or of
such rights contrary to the provisions hereof, or upon the levy of any
attachment or similar process upon the Option or such rights, the Option and
such rights shall, at the election of the Company, become null and void.

      7. No Special Employment Rights. Nothing contained in the Plan or this
Agreement shall be construed or deemed by any person under any circumstances to
bind the Company or any Parent Corporation or Subsidiary to continue the
employment of the Associate for the period within which the Option may be
exercised. Moreover, during the period of the Associate's employment, the
Associate shall render diligently and faithfully the services which are assigned
to the Associate from time to time by the Board of Directors or by the executive
officers of the Company or any Parent Corporation or Subsidiary and shall at no
time take any action which directly or indirectly would be inconsistent with the
best interests of the foregoing entities.

      8. Rights as a Shareholder. The Associate shall have no rights as a
Shareholder with respect to any Shares which may be purchased by exercise of the
Option unless and until a certificate representing such Shares is duly issued
and delivered to the Associate. No adjustment shall be made for dividends or
other rights for which the

<PAGE>

record date is prior to the date such stock certificate is issued except as
provided for in Sections 9 or 10 of this Agreement.

      9. Recapitalization. In the event that the outstanding shares of Common
Stock of the Company are changed into or exchanged for a different number or
kind of shares or other securities of the Company by reason of any
recapitalization, reclassification, stock split, stock dividend, combination or
subdivision, appropriate adjustment shall be made in the number and kind of
Shares to which the Option shall be exercisable. Such adjustment to the Option
shall be made without change in the total price applicable to the unexercised
portion of the Option, and a corresponding adjustment in the Exercise Price per
Share shall be made. No such adjustment shall be made which would, within the
meaning of any applicable provisions of the Code, constitute a modification,
extension or renewal of the Option or a grant of additional benefits to the
Associate.

      10. Reorganization of the Company. In case (i) the Company is merged or
consolidated with another corporation and the Company is not the surviving
corporation, (ii) all or substantially all of the assets or more than 50% of the
outstanding voting stock of the Company is acquired by any other corporation or
(iii) the Company is reorganized or liquidated prior to the Expiration Date, the
Board of Directors of the Company, or the board of directors of any corporation
assuming the obligations of the Company, shall, as to the Option, either (x)
make appropriate provision for the protection of the Option by the substitution
on an equitable basis of appropriate stock of the Company, or of the merged,
consolidated or otherwise reorganized corporation which will be issuable in
respect of the shares of Common Stock of the Company, provided that no
additional benefits shall be conferred upon the Associate as a result of such
substitution, and the excess of the aggregate fair market value of the Shares
subject to the Option immediately after such substitution over the purchase
price thereof is not more than the excess of the aggregate fair market value of
the Shares subject to the Option immediately before such substitution over the
purchase price thereof, or (y) upon written notice to the Associate, provide
that the Option must be exercised within a specified number of days of the date
of such notice or they will be terminated. In any such case, the Board of
Directors may, in its discretion, accelerate the exercise dates of the Option.

      11.   Withholding Taxes.  The Company's obligation to deliver Shares
upon the exercise of the Option shall be subject to the Associate's
satisfaction of all applicable federal, state and local income and employment
tax withholding requirements.

      12.   Investment Representations; Legend.

            (a)   Representations.  As of the time of any exercise of the
Option, the Associate represents, warrants and covenants to the Company that:

                  (i) Any Shares purchased upon exercise of the Option shall be
acquired for the Associate's account for investment only and not with a view to,
or for

<PAGE>

sale in connection with, any distribution of the Shares in violation of the
Securities Act, or any rule or regulation thereunder.

                  (ii) The Associate has had such opportunity as he or she has
deemed adequate to obtain from representatives of the Company such information
as is necessary to permit the Associate to evaluate the merits and risks of an
investment in the Company.

                  (iii) The Associate is able to bear the economic risk of
holding such Shares for an indefinite period.

                  (iv) The Associate understands that (A) the Shares will not be
registered under the Securities Act and are "restricted securities" within the
meaning of Rule 144 under the Securities Act; (B) the Shares cannot be sold,
transferred or otherwise disposed of unless they are subsequently registered
under the Securities Act or an exemption from registration is then available;
(C) in any event, the exemption from registration under Rule 144 will not be
available for at least one year and even then will not be available unless a
public market then exists for the Company's Common Stock, adequate information
concerning the Company is then available to the public, and other terms and
conditions of Rule 144 are complied with; and (D) the Company has no obligation
or current intention to register any Shares acquired pursuant to the exercise of
the Option under the Securities Act.

            (b)   Tax Consequences.  The Associate hereby represents that the
Associate has obtained appropriate legal or tax advice with respect to the
tax consequences to the Associate of exercising the Option and selling the
Shares.

            (c) Legend on Stock Certificates. All stock certificates
representing Shares issued to the Associate upon exercise of the Option shall
have affixed thereto legends substantially in the following form, in addition to
any other legends required by applicable state law:

            THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
            UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
            SECURITIES LAWS AND MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED,
            HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1)
            REGISTRATION IN COMPLIANCE WITH SAID ACT AND SUCH STATE LAWS, OR (2)
            AN OPINION OF COUNSEL FOR THE COMPANY TO THE EFFECT THAT SUCH
            DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF ANY RELEVANT FEDERAL
            OR STATE SECURITIES LAWS.

            THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF
            FIRST REFUSAL AND RESTRICTIONS ON

<PAGE>

            RESALE CONTAINED IN A STOCK OPTION AGREEMENT BETWEEN THE COMPANY AND
            THE HOLDER HEREOF. A COPY OF SUCH AGREEMENT IS ON FILE AT THE
            PRINCIPAL OFFICES OF THE COMPANY.

            By making payment upon exercise of the Option, the Associate shall
be deemed to have reaffirmed, as of the date of such payment, the
representations made in this Section 12.

      13.   Limitations on Dispositions of Incentive Stock Options.

            (a) Prohibitions on Sales of Shares. It is understood and intended
that the Option shall qualify as an Incentive Stock Option. Accordingly, the
Associate understands that in order to obtain the benefits of an incentive stock
option under Section 421 of the Code, no sale or other disposition may be made
of any Shares acquired upon exercise of the Option within the one year period
beginning on the day after the day of the transfer of such Shares to him or her,
nor within the two-year period beginning on the day after the date of this
Agreement. If the Associate intends to dispose or does dispose (whether by sale,
exchange, gift, transfer or otherwise) of any such Shares within said periods,
he or she will notify the Company in writing within ten days after such
disposition.

            (b) Maximum Number of Incentive Stock Options Exercisable During One
Year. To the extent that the aggregate fair market value (determined as of the
time an option is granted pursuant to the Plan) of Common Stock with respect to
which an option becomes exercisable for the first time by the Associate during
any calendar year under the Plan and all similar plans maintained by the Company
exceeds $100,000.00, options for such Common Stock shall be treated as options
that are not Incentive Stock Options. For purposes of this provision, Options
shall be taken into account in the order in which they were granted.

      14. Right of First Refusal. If the Associate wishes to sell or otherwise
transfer any of the Shares, then at least 30 days prior to any such transfer,
the Associate shall give notice to the Company (the "Notice"). The Notice shall
set forth (i) the number of Shares proposed to be sold or transferred; (ii) the
date or proposed date of the sale or transfer; (iii) the identity of the
proposed transferee; and (iv) the principal terms of the transfer, including the
cash or other property or consideration to be received upon such transfer. The
Company shall have the right, but not the obligation, to purchase all, but not
less than all, of the Shares on the same terms specified in the Notice. Within
30 days after receipt of the Notice, the Company shall give written notice (the
"Company Notice") to the Associate stating whether or not it elects to exercise
its right to purchase the Shares and a date and time for consummation of such
purchase, not more than 10 days after the receipt by the Associate of the
Company Notice. Failure by the Company to deliver a Company Notice within such
time period shall be deemed an election by the Company not to exercise its right
to purchase the Shares. If the Company does not exercise its right

<PAGE>

to purchase the Shares, then the Associate shall be free to transfer the Shares
on the terms provided in the Notice. Any Shares not purchased within a period of
90 days of the Notice by the proposed transferee in the Notice may not be sold
or otherwise disposed of until they are again offered to the Company under the
procedures specified in this Section 14. The Company's right of first refusal
described in this Section 14 shall terminate upon the closing of an initial
public offering of the Company's Common Stock.

      15. Restrictions on Public Sale by Associate. In connection with any
public offering, the Associate, if requested by the Company and the underwriters
managing such public offering, shall agree not to sell or otherwise transfer or
dispose of any Shares or other securities of the Company held by the Associate
(other than those Shares or other securities, if any, included in the public
offering) for a specified period of time determined by the Company and the
underwriters following the effective date of a registration statement with the
Securities and Exchange Commission covering such public offering (the
"Registration Statement"); provided, however, that: (i) such agreement shall not
exceed 180 days from the effective date of such registration; (ii) all other
Restricted Holders enter into similar agreements; provided, however, that all
restrictions set forth in this Section 15 shall terminate and be of no further
force or effect if any other Restricted Holder is released from, or otherwise no
longer bound by, such restrictions; and (iii) such agreement shall only apply to
the first such Registration Statement covering Common Stock of the Company to be
sold on its behalf to the public in an initial public offering of securities by
the Company. For purposes of this Section 15, "Restricted Holders" shall mean:
(x) parties to that certain Third Amended and Restated Investor Rights
Agreement, dated September 13, 2006, by and among the Company and the
stockholders named therein, and (y) any officer or director of the Company.

      16.   Miscellaneous.

            (a) This Agreement and any instruments delivered pursuant to this
Agreement shall be construed, interpreted and governed in accordance with the
laws of the State of New Jersey, without regard to the conflicts of law rules
thereof.

            (b) Any claim or controversy arising out of, or relating to, this
Agreement, other than with respect to any confidentiality agreement between
Associate and the Company (or any officer, director, employee or agent of the
Company), or the breach thereof, shall be settled by arbitration administrated
by the American Arbitration Association under its National Rules for the
Resolution of Employment Disputes. Such arbitration shall be held in New Jersey
(or in such other location as the Company may at the time be headquartered). The
arbitration shall be conducted before a three-member panel. Within fifteen (15)
days after the commencement of arbitration, each party shall select one person
to act as arbitrator and the two selected shall select a third arbitrator within
ten (10) days of their appointment. If the arbitrators selected by the parties
are unable or fail to agree upon the third arbitrator, the third arbitrator
shall be selected by the American Arbitration Association and shall be a member
of the bar of the State of New

<PAGE>

Jersey actively engaged in the practice of employment law for at least ten
years. The arbitration panel shall apply the substantive laws of the State of
New Jersey in connection with the arbitration and the New Jersey Rules of
Evidence shall apply to all aspects of the arbitration. The award shall be made
within thirty days of the closing of the hearing. Judgment upon the award
rendered by the arbitrator(s) may be entered by any Court having jurisdiction
thereof.

            (c) This Agreement shall extend to, be binding upon and inure to the
benefit of the Associate, his legal representatives, his heirs, successors and
assigns (subject, however, to the limitations set forth herein with respect to
the assignment of the Option or rights herein) and upon the Company, its
successors and assigns regardless of any change in the business structure of the
Company, be it through spinoff, merger, sale of stock, sale of assets or any
other transaction and shall be construed in a manner that is consistent with the
provisions of the Plan.

            (d) This Agreement contains the entire agreement of the parties with
respect to the subject matter hereof. No waiver, modification or change of any
provision of this Agreement shall be valid unless in writing and signed by both
parties.

            (e) The waiver of any breach of any duty, term or condition of this
Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

            (f) All notices pursuant to this Agreement will be in writing and
will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the parties
hereto at the addresses set forth beneath their names on the signature page
hereto or to such other addresses as may hereafter be specified by like notice
in writing by either of the parties, and will be deemed given (i) upon receipt
if by personal delivery, (ii) on the day on which delivered if delivered by
telecopier (with confirmation of receipt (such receipt to be established by
acceptable protocol)), (iii) upon mailing if sent by registered or certified
mail or (iv) when transmitted if delivered by electronic mail (with satisfactory
evidence of transmittal (such evidence of transmittal to be established by
acceptable protocol)). Copies of all notices shall be sent to: Amicus
Therapeutics, Inc., 6 Cedar Brook Drive, Cranbury, NJ 08512 Attention: VP, Human
Resources and Leadership Development, Telecopier No.609-662-2004.

            (g) The headings of the sections of this Agreement are inserted for
convenience of reference only and will not be deemed to constitute a part hereof
or to affect the meaning hereof.

            (h) This Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which shall together constitute one and
the same Agreement.

<PAGE>

Date of Grant:                           Amicus Therapeutics, Inc.

- ______, 200_                           By:
                                            -----------------------------------
                                            Name:    John F. Crowley
Initial Date of                             Title:   President & CEO
Employment:

- ____________, 200_                     Address: 6 Cedar Brook Drive
                                                  Cranbury, NJ 08512

                             ASSOCIATE'S ACCEPTANCE

      The undersigned hereby accepts the foregoing Agreement and agrees to the
terms and conditions thereof. The undersigned hereby acknowledges receipt of a
copy of the Company's 2002 Equity Incentive Plan.

                                      ASSOCIATE

                                      -----------------------------------------
                                      Name:       -
                                      Address:    -

                                      SSN#:       -
<PAGE>
                            AMICUS THERAPEUTICS, INC.

                        INCENTIVE STOCK OPTION AGREEMENT

      1. Grant of Option. Amicus Therapeutics, Inc., a Delaware corporation (the
"Company"), hereby grants to _______ (the "Associate"), an option (the
"Option"), pursuant to the Company's 2002 Equity Incentive Plan (the "Plan"), to
purchase up to an aggregate of _______ shares (the "Shares") of Common Stock,
$0.01 par value ("Common Stock"), of the Company at a price of $______ per Share
(the "Exercise Price"), purchasable as set forth in and subject to the terms and
conditions of this Agreement and the Plan.

      2. Incentive Stock Option. The Option is intended to qualify as an
incentive stock option ("Incentive Stock Option") within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the "Code").

      3. Exercise of Option and Provisions for Termination.

            (a) Exercisability of Option. The Option shall become exercisable as
follows: ______ shares shall vest and become exercisable on the first
anniversary (the "Anniversary Date") of the date of grant set forth on the
signature page hereof (the "Date of Grant"). The remaining shares shall vest and
become exercisable in equal monthly installments of ____ shares on the first day
of each of the next 35 calendar months, beginning on the first day of the
calendar month next following the Anniversary Date, and ______ shares shall vest
and become exercisable on _______________. The periods of time following the
Associate's cessation of service, death or disability, during which the Option
remains outstanding as provided in subsections (e) and (f) below, shall not be
included for purposes of determining the exercisability of the Option under this
subsection (a).

            (b) Expiration Date. Except as otherwise provided in this Agreement,
the Option may not be exercised after the date (hereinafter the "Expiration
Date") that is the tenth anniversary of the Date of Grant or, if the Associate
is a "10% Shareholder" as described in Section 11(b) of the Plan, the fifth
anniversary of the Date of Grant.

            (c) Exercise Procedure. Subject to the conditions set forth in this
Agreement, the Option shall be exercised by the Associate's delivery of written
notice of exercise to the Company's VP of Human Resources and Leadership
Development (the "VP HR"), specifying the number of Shares to be purchased and
the aggregate Exercise Price to be paid therefor, accompanied by payment in full
in accordance with Section 4. Such exercise shall be effective upon receipt by
the VP HR of such written notice together with the required payment. The
Associate may purchase less than the total number of Shares covered hereby,
provided that no partial exercise of the Option may be for any fractional Share
or for less than ten whole Shares.

<PAGE>

            (d) Continuous Employment Required. Except as otherwise provided in
this Section 3, the Option may not be exercised unless the Associate, at the
time he or she exercises the Option, is, and has been at all times since the
Date of Grant of the Option, an employee of one or more of the Company, a Parent
Corporation or a Subsidiary (as such terms are defined in the Plan). For all
purposes of this Agreement, (i) "employment" shall be defined in accordance with
the provisions of Section 1.421-7(h) of the Income Tax Regulations or any
successor regulations, and (ii) if the Option shall be assumed or a new option
substituted therefor in a transaction to which Section 424(a) of the Code
applies, employment by such assuming or substituting corporation (hereinafter
called the "Successor Corporation") or by a Parent Corporation or a Subsidiary
thereof (as defined in the Plan, respectively, but with the Successor
Corporation substituted for the Company in such definitions) shall be considered
for all purposes of this Agreement to be employment by the Company, a Parent
Corporation or a Subsidiary, as the case may be.

            (e) Termination of Employment. If the Associate ceases to be
employed by the Company, a Parent Corporation or Subsidiary for any reason other
than death or disability or a discharge for "cause", the right to exercise the
Option shall terminate three months after such cessation (but in no event after
the Expiration Date).

            (f) Exercise Period Upon Death or Disability. If the Associate dies
or becomes disabled (within the meaning of Section 22(e) (3) of the Code) prior
to the Expiration Date, while he or she is an employee of the Company, a Parent
Corporation or a Subsidiary, or if the Associate dies within three months after
the Associate ceases to be an employee of any of the foregoing entities (other
than as the result of a discharge for "cause" as specified in subsection (g)
below), the Option shall be exercisable, within the period of one year following
the date of death or disability of the Associate (but in no event after the
Expiration Date), by the Associate, the Associate's legal representative (in the
event of legal incapacity) or by the person to whom the Option is transferred by
will or the laws of descent and distribution. Except as otherwise indicated by
the context, the term "Associate", as used in this Agreement, shall be deemed to
include the estate of the Associate, or any person who acquirers the right to
exercise the Option by bequest or inheritance or otherwise by reason of the
death of the Associate.

            (g) Discharge for Cause. If the Associate, prior to the Expiration
Date, ceases his or her employment with the Company, a Parent Corporation or a
Subsidiary because he or she is discharged for "cause" (as defined below), the
right to exercise the Option shall terminate immediately upon such cessation of
employment. "Cause" shall mean willful misconduct in connection with the
Associate's employment or willful failure to perform his or her employment
responsibilities in the best interests of his or her employer, as determined by
the Company, which determination shall be conclusive.

<PAGE>

      4. Payment of Exercise Price. Payment of the aggregate Exercise Price for
Shares purchased upon exercise of the Option shall be made by delivery to the
Company of cash or a check to the order of the Company.

      5. Delivery of Shares. The Company shall, upon payment of the aggregate
Exercise Price for the number of Shares purchased and paid for, make prompt
delivery of such Shares to the Associate, provided that if any law or regulation
requires the Company to take any action with respect to such Shares before the
issuance thereof, then the date of delivery of such Shares shall be extended for
the period necessary to complete such action. No Shares shall be issued and
delivered upon exercise of the Option unless and until, in the opinion of
counsel for the Company, any applicable registration requirements of the
Securities Act of 1933, as amended (the "Securities Act"), any applicable
listing requirements of any national securities exchange on which stock of the
same class is then listed, and any other requirements of law or of any
regulatory bodies having jurisdiction over such issuance and delivery, shall
have been fully complied with.

      6. Non-transferability of Option. Except as provided in subsection (f) of
Section 3, or as otherwise agreed to by the Board of Directors or the
Compensation Committee of the Board of Directors, the Option is personal and no
rights granted hereunder may be transferred, assigned, pledged or hypothecated
in any way (whether by operation of law or otherwise) nor shall any such rights
be subject to execution, attachment or similar process. Upon any attempt to
transfer, assign, pledge, hypothecate or otherwise dispose of the Option or of
such rights contrary to the provisions hereof, or upon the levy of any
attachment or similar process upon the Option or such rights, the Option and
such rights shall, at the election of the Company, become null and void.

      7. No Special Employment Rights. Nothing contained in the Plan or this
Agreement shall be construed or deemed by any person under any circumstances to
bind the Company or any Parent Corporation or Subsidiary to continue the
employment of the Associate for the period within which the Option may be
exercised. Moreover, during the period of the Associate's employment, the
Associate shall render diligently and faithfully the services which are assigned
to the Associate from time to time by the Board of Directors or by the executive
officers of the Company or any Parent Corporation or Subsidiary and shall at no
time take any action which directly or indirectly would be inconsistent with the
best interests of the foregoing entities.

      8. Rights as a Shareholder. The Associate shall have no rights as a
Shareholder with respect to any Shares which may be purchased by exercise of the
Option unless and until a certificate representing such Shares is duly issued
and delivered to the Associate. No adjustment shall be made for dividends or
other rights for which the record date is prior to the date such stock
certificate is issued except as provided for in Sections 9 or 10 of this
Agreement.

      9. Recapitalization. In the event that the outstanding shares of Common
Stock of the Company are changed into or exchanged for a different number or
kind of

<PAGE>

shares or other securities of the Company by reason of any recapitalization,
reclassification, stock split, stock dividend, combination or subdivision,
appropriate adjustment shall be made in the number and kind of Shares to which
the Option shall be exercisable. Such adjustment to the Option shall be made
without change in the total price applicable to the unexercised portion of the
Option, and a corresponding adjustment in the Exercise Price per Share shall be
made. No such adjustment shall be made which would, within the meaning of any
applicable provisions of the Code, constitute a modification, extension or
renewal of the Option or a grant of additional benefits to the Associate.

      10. Reorganization of the Company. In case (i) the Company is merged or
consolidated with another corporation and the Company is not the surviving
corporation, (ii) all or substantially all of the assets or more than 50% of the
outstanding voting stock of the Company is acquired by any other corporation or
(iii) the Company is reorganized or liquidated prior to the Expiration Date, the
Board of Directors of the Company, or the board of directors of any corporation
assuming the obligations of the Company, shall, as to the Option, either (x)
make appropriate provision for the protection of the Option by the substitution
on an equitable basis of appropriate stock of the Company, or of the merged,
consolidated or otherwise reorganized corporation which will be issuable in
respect of the shares of Common Stock of the Company, provided that no
additional benefits shall be conferred upon the Associate as a result of such
substitution, and the excess of the aggregate fair market value of the Shares
subject to the Option immediately after such substitution over the purchase
price thereof is not more than the excess of the aggregate fair market value of
the Shares subject to the Option immediately before such substitution over the
purchase price thereof, or (y) upon written notice to the Associate, provide
that the Option must be exercised within a specified number of days of the date
of such notice or they will be terminated. In any such case, the Board of
Directors may, in its discretion, accelerate the exercise dates of the Option.

      11. Withholding Taxes. The Company's obligation to deliver Shares upon the
exercise of the Option shall be subject to the Associate's satisfaction of all
applicable federal, state and local income and employment tax withholding
requirements.

      12. Investment Representations; Legend.

            (a) Representations. As of the time of any exercise of the Option,
the Associate represents, warrants and covenants to the Company that:

                  (i) Any Shares purchased upon exercise of the Option shall be
acquired for the Associate's account for investment only and not with a view to,
or for sale in connection with, any distribution of the Shares in violation of
the Securities Act, or any rule or regulation thereunder.

                  (ii) The Associate has had such opportunity as he or she has
deemed adequate to obtain from representatives of the Company such information
as is

<PAGE>

necessary to permit the Associate to evaluate the merits and risks of an
investment in the Company.

                  (iii) The Associate is able to bear the economic risk of
holding such Shares for an indefinite period.

                  (iv) The Associate understands that (A) the Shares will not be
registered under the Securities Act and are "restricted securities" within the
meaning of Rule 144 under the Securities Act; (B) the Shares cannot be sold,
transferred or otherwise disposed of unless they are subsequently registered
under the Securities Act or an exemption from registration is then available;
(C) in any event, the exemption from registration under Rule 144 will not be
available for at least one year and even then will not be available unless a
public market then exists for the Company's Common Stock, adequate information
concerning the Company is then available to the public, and other terms and
conditions of Rule 144 are complied with; and (D) the Company has no obligation
or current intention to register any Shares acquired pursuant to the exercise of
the Option under the Securities Act.

            (b) Tax Consequences. The Associate hereby represents that the
Associate has obtained appropriate legal or tax advice with respect to the tax
consequences to the Associate of exercising the Option and selling the Shares.

            (c) Legend on Stock Certificates. All stock certificates
representing Shares issued to the Associate upon exercise of the Option shall
have affixed thereto legends substantially in the following form, in addition to
any other legends required by applicable state law:

            THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
            UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
            SECURITIES LAWS AND MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED,
            HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1)
            REGISTRATION IN COMPLIANCE WITH SAID ACT AND SUCH STATE LAWS, OR (2)
            AN OPINION OF COUNSEL FOR THE COMPANY TO THE EFFECT THAT SUCH
            DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF ANY RELEVANT FEDERAL
            OR STATE SECURITIES LAWS.

            THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF
            FIRST REFUSAL CONTAINED IN A STOCK OPTION AGREEMENT BETWEEN THE
            COMPANY AND THE HOLDER HEREOF. A COPY OF SUCH AGREEMENT IS ON FILE
            AT THE PRINCIPAL OFFICES OF THE COMPANY.

<PAGE>

            By making payment upon exercise of the Option, the Associate shall
be deemed to have reaffirmed, as of the date of such payment, the
representations made in this Section 12.

      13. Limitations on Dispositions of Incentive Stock Options.

            (a) Prohibitions on Sales of Shares. It is understood and intended
that the Option shall qualify as an Incentive Stock Option. Accordingly, the
Associate understands that in order to obtain the benefits of an incentive stock
option under Section 421 of the Code, no sale or other disposition may be made
of any Shares acquired upon exercise of the Option within the one year period
beginning on the day after the day of the transfer of such Shares to him or her,
nor within the two-year period beginning on the day after the date of this
Agreement. If the Associate intends to dispose or does dispose (whether by sale,
exchange, gift, transfer or otherwise) of any such Shares within said periods,
he or she will notify the Company in writing within ten days after such
disposition.

            (b) Maximum Number of Incentive Stock Options Exercisable During One
Year. To the extent that the aggregate fair market value (determined as of the
time an option is granted pursuant to the Plan) of Common Stock with respect to
which an option becomes exercisable for the first time by the Associate during
any calendar year under the Plan and all similar plans maintained by the Company
exceeds $100,000.00, options for such Common Stock shall be treated as options
that are not Incentive Stock Options. For purposes of this provision, Options
shall be taken into account in the order in which they were granted.

      14. Right of First Refusal. If the Associate wishes to sell or otherwise
transfer any of the Shares, then at least 30 days prior to any such transfer,
the Associate shall give notice to the Company (the "Notice"). The Notice shall
set forth (i) the number of Shares proposed to be sold or transferred; (ii) the
date or proposed date of the sale or transfer; (iii) the identity of the
proposed transferee; and (iv) the principal terms of the transfer, including the
cash or other property or consideration to be received upon such transfer. The
Company shall have the right, but not the obligation, to purchase all, but not
less than all, of the Shares on the same terms specified in the Notice. Within
30 days after receipt of the Notice, the Company shall give written notice (the
"Company Notice") to the Associate stating whether or not it elects to exercise
its right to purchase the Shares and a date and time for consummation of such
purchase, not more than 10 days after the receipt by the Associate of the
Company Notice. Failure by the Company to deliver a Company Notice within such
time period shall be deemed an election by the Company not to exercise its right
to purchase the Shares. If the Company does not exercise its right to purchase
the Shares, then the Associate shall be free to transfer the Shares on the terms
provided in the Notice. Any Shares not purchased within a period of 90 days of
the Notice by the proposed transferee in the Notice may not be sold or otherwise
disposed of until they are again offered to the Company under the procedures
specified in this Section

<PAGE>

14. The Company's right of first refusal described in this Section 14 shall
terminate upon the closing of an initial public offering of the Company's Common
Stock.

      15. Miscellaneous.

            (a) This Agreement and any instruments delivered pursuant to this
Agreement shall be construed, interpreted and governed in accordance with the
laws of the State of New Jersey, without regard to the conflicts of law rules
thereof.

            (b) Any claim or controversy arising out of, or relating to, this
Agreement, other than with respect to any confidentiality agreement between
Associate and the Company (or any officer, director, employee or agent of the
Company), or the breach thereof, shall be settled by arbitration administrated
by the American Arbitration Association under its National Rules for the
Resolution of Employment Disputes. Such arbitration shall be held in New Jersey
(or in such other location as the Company may at the time be headquartered). The
arbitration shall be conducted before a three-member panel. Within fifteen (15)
days after the commencement of arbitration, each party shall select one person
to act as arbitrator and the two selected shall select a third arbitrator within
ten (10) days of their appointment. If the arbitrators selected by the parties
are unable or fail to agree upon the third arbitrator, the third arbitrator
shall be selected by the American Arbitration Association and shall be a member
of the bar of the State of New Jersey actively engaged in the practice of
employment law for at least ten years. The arbitration panel shall apply the
substantive laws of the State of New Jersey in connection with the arbitration
and the New Jersey Rules of Evidence shall apply to all aspects of the
arbitration. The award shall be made within thirty days of the closing of the
hearing. Judgment upon the award rendered by the arbitrator(s) may be entered by
any Court having jurisdiction thereof.

            (c) This Agreement shall extend to, be binding upon and inure to the
benefit of the Associate, his legal representatives, his heirs, successors and
assigns (subject, however, to the limitations set forth herein with respect to
the assignment of the Option or rights herein) and upon the Company, its
successors and assigns regardless of any change in the business structure of the
Company, be it through spinoff, merger, sale of stock, sale of assets or any
other transaction and shall be construed in a manner that is consistent with the
provisions of the Plan.

            (d) This Agreement contains the entire agreement of the parties with
respect to the subject matter hereof. No waiver, modification or change of any
provision of this Agreement shall be valid unless in writing and signed by both
parties.

            (e) The waiver of any breach of any duty, term or condition of this
Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

<PAGE>

            (f) All notices pursuant to this Agreement will be in writing and
will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the parties
hereto at the addresses set forth beneath their names on the signature page
hereto or to such other addresses as may hereafter be specified by like notice
in writing by either of the parties, and will be deemed given (i) upon receipt
if by personal delivery, (ii) on the day on which delivered if delivered by
telecopier (with confirmation of receipt (such receipt to be established by
acceptable protocol)), (iii) upon mailing if sent by registered or certified
mail or (iv) when transmitted if delivered by electronic mail (with satisfactory
evidence of transmittal (such evidence of transmittal to be established by
acceptable protocol)). Copies of all notices shall be sent to: Amicus
Therapeutics, Inc., 6 Cedar Brook Drive, Cranbury, NJ 08512 Attention: VP, Human
Resources and Leadership Development, Telecopier No.609-662-2004.

            (g) The headings of the sections of this Agreement are inserted for
convenience of reference only and will not be deemed to constitute a part hereof
or to affect the meaning hereof.

            (h) This Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which shall together constitute one and
the same Agreement.

<PAGE>

Date of Grant:                          Amicus Therapeutics, Inc.

-                                       By:
  ----------                               -------------------------------------
                                           Name:      John F. Crowley
                                           Title:     Chairman & CEO

                                         Address:   6 Cedar Brook Drive
                                                    Cranbury, NJ 08512

                             ASSOCIATE'S ACCEPTANCE

      The undersigned hereby accepts the foregoing Agreement and agrees to the
terms and conditions thereof. The undersigned hereby acknowledges receipt of a
copy of the Company's 2002 Equity Incentive Plan.

                                        ASSOCIATE

                                        ----------------------------------------
                                        Name:          -
                                        Address:       -

                                        SSN#:          -
<PAGE>
                                                                  EXECUTION COPY

                            AMICUS THERAPEUTICS, INC.

                        INCENTIVE STOCK OPTION AGREEMENT

            1.    Grant of Option.  Amicus Therapeutics, Inc., a Delaware
corporation (the "Company"), hereby grants to NAME (the "Associate"), an
option (the "Option"), pursuant to the Company's 2002 Equity Incentive Plan
(the "Plan"), to purchase up to an aggregate of #SHARES shares (the "Shares")
of Common Stock, $.01 par value ("Common Stock"), of the Company at a price
of $PRICE per Share (the "Exercise Price"), purchasable as set forth in and
subject to the terms and conditions of this Agreement and the Plan.

            2.    Incentive Stock Option.  The Option is intended to qualify
as an incentive stock option ("Incentive Stock Option") within the meaning of
Section 422 of the Internal Revenue Code of 1986, as amended (the "Code").

            3.    Exercise of Option and Provisions for Termination.

                  (a) Exercisability of Option. Unless otherwise provided in
this Section 3, the Option shall vest and become exercisable as set forth in the
following schedule:

<Table>
<Caption>
Vesting Date                         Number of Shares
------------                         ----------------
<S>                                  <C>

DATE (the "Anniversary Date")               #

Each monthly anniversary of                 #
the Anniversary Date,
beginning on DATE through DATE

DATE                                        #
</Table>

The periods of time following the Associate's cessation of service, death or
disability, during which the Option remains outstanding as provided in
subsections (g) and (h) below, shall not be included for purposes of determining
the exercisability of the Option under this subsection (a).

<PAGE>

                  (b)   Acceleration of Vesting.

                        (i) Resignation for Good Reason after Change in Control
            Event. If, prior to the expiration of the term of Associate's
            employment with the Company (the "Employment Term") pursuant to that
            certain offer letter dated DATE of LETTER, but after the occurrence
            of a Change in Control Event (as defined below), the Associate
            resigns for Good Reason (as defined below) within six (6) months of
            such Change in Control Event, then the entire Option shall vest and
            immediately become fully exercisable.

                        (ii) Termination by the Company without Cause. If, prior
            to the expiration of the Employment Term, the Company terminates
            Associate's employment without Cause (as defined below), then the
            Option shall vest and become exercisable with respect to an
            additional six (6) months of vesting, measured from the date of
            termination of employment.

                        (iii) Release. In order for the vesting of the Option to
            accelerate as provided in this Section 3(b), Associate must execute
            and deliver to the Company a release, the form and substance of
            which are acceptable to the Company.

                  (c)   Definitions.  For purposes of this Section 3, the
following definitions shall have the meanings set forth below:

                        (i) "Cause" means for any of the following reasons: (i)
            willful or deliberate misconduct by Associate that materially
            damages the Company; (ii) misappropriation of Company assets; (iii)
            Associate's conviction of or a plea of guilty or "no contest" to, a
            felony; or (iv) any willful disobedience of the lawful and
            unambiguous instructions of the Chief Executive Officer of the
            Company; provided that the Chief Executive Officer has given
            Associate written notice of such disobedience or neglect and
            Associate has failed to cure such disobedience or neglect within a
            period reasonable under the circumstances.

                        (ii) "Change in Control Event" means any of the
            following: (i) any person or entity (except for a current
            stockholder) becomes the beneficial owner of greater than 50% of the
            then outstanding voting power of the Company; (ii) a merger or
            consolidation with another entity where the voting securities of the
            Company outstanding immediately before the transaction constitute
            less than a majority of the voting power of the voting securities of
            the Company or the surviving

                                       2
<PAGE>

            entity outstanding immediately after the transaction, or (iii) the
            sale or disposition of all or substantially all of the company's
            assets.

                        (iii) "Good Reason" means (i) a change in Associate's
            position with the Company or its successor that materially reduces
            Associate's title, duties or level of responsibility; or (ii) the
            relocation of the Company or its successor greater than 50 miles
            away from the then current location of the Company's principal
            offices.

                  (d) Expiration Date. Except as otherwise provided in this
Agreement, the Option may not be exercised after the date (hereinafter the
"Expiration Date") that is the tenth anniversary of the date of grant set forth
on the signature page hereof (the "Date of Grant") or, if the Associate is a
"10% Shareholder" as described in Section 7(b) of the Plan, the fifth
anniversary of the Date of Grant.

                  (e) Exercise Procedure. Subject to the conditions set forth in
this Agreement, the Option shall be exercised by the Associate's delivery of
written notice of exercise to the chief financial officer of the Company,
specifying the number of Shares to be purchased and the aggregate Exercise Price
to be paid therefor, accompanied by payment in full in accordance with Section
4. Such exercise shall be effective upon receipt by the chief financial officer
of the Company of such written notice together with the required payment. The
Associate may purchase less than the total number of Shares covered hereby,
provided that no partial exercise of the Option may be for any fractional Share
or for less than ten whole Shares.

                  (f) Continuous Employment Required. Except as otherwise
provided in this Section 3, the Option may not be exercised unless the
Associate, at the time he or she exercises the Option, is, and has been at all
times since the Date of Grant of the Option, an employee of one or more of the
Company, a Parent Corporation or a Subsidiary (as such terms are defined in the
Plan). For all purposes of this Agreement, (i) "employment" shall be defined in
accordance with the provisions of Section 1.421-7(h) of the Income Tax
Regulations or any successor regulations, and (ii) if the Option shall be
assumed or a new option substituted therefor in a transaction to which Section
424(a) of the Code applies, employment by such assuming or substituting
corporation (hereinafter called the "Successor Corporation") or by a Parent
Corporation or a Subsidiary thereof (as defined in the Plan, respectively, but
with the Successor Corporation substituted for the Company in such definitions)
shall be considered for all purposes of this Agreement to be employment by the
Company, a Parent Corporation or a Subsidiary, as the case may be.

                  (g) Termination of Employment. If the Associate ceases to be
employed by the Company, a Parent Corporation or Subsidiary for any reason other
than death or disability or a discharge for Cause the right to exercise the
Option shall terminate three months after such cessation (but in no event after
the Expiration Date).

                                       3
<PAGE>

                  (h) Exercise Period Upon Death or Disability. If the Associate
dies or becomes disabled (within the meaning of Section 22(e)(3) of the Code)
prior to the Expiration Date, while he or she is an employee of the Company, a
Parent Corporation or a Subsidiary, or if the Associate dies within three months
after the Associate ceases to be an employee of any of the foregoing entities
(other than as the result of a discharge for "cause" as specified in subsection
(i) below), the Option shall be exercisable, within the period of one year
following the date of death or disability of the Associate (but in no event
after the Expiration Date), by the Associate, the Associate's legal
representative (in the event of legal incapacity) or by the person to whom the
Option is transferred by will or the laws of descent and distribution. Except as
otherwise indicated by the context, the term "Associate", as used in this
Agreement, shall be deemed to include the estate of the Associate, or any person
who acquirers the right to exercise the Option by bequest or inheritance or
otherwise by reason of the death of the Associate.

                  (i) Discharge for Cause. If the Associate, prior to the
Expiration Date, ceases his or her employment with the Company, a Parent
Corporation or a Subsidiary because he or she is discharged for Cause, the right
to exercise the Option shall terminate immediately upon such cessation of
employment.

            4.    Payment of Exercise Price.  Payment of the aggregate
Exercise Price for Shares purchased upon exercise of the Option shall be made
by delivery to the Company of cash or a check to the order of the Company.

            5. Delivery of Shares. The Company shall, upon payment of the
aggregate Exercise Price for the number of Shares purchased and paid for, make
prompt delivery of such Shares to the Associate, provided that if any law or
regulation requires the Company to take any action with respect to such Shares
before the issuance thereof, then the date of delivery of such Shares shall be
extended for the period necessary to complete such action. No Shares shall be
issued and delivered upon exercise of the Option unless and until, in the
opinion of counsel for the Company, any applicable registration requirements of
the Securities Act of 1933, as amended (the "Securities Act"), any applicable
listing requirements of any national securities exchange on which stock of the
same class is then listed, and any other requirements of law or of any
regulatory bodies having jurisdiction over such issuance and delivery, shall
have been fully complied with.

            6. Non-transferability of Option. Except as provided in subsection
(h) of Section 3, or as otherwise agreed to by the Board of Directors or a
committee thereof, the Option is personal and no rights granted hereunder may be
transferred, assigned, pledged or hypothecated in any way (whether by operation
of law or otherwise) nor shall any such rights be subject to execution,
attachment or similar process. Upon any attempt to transfer, assign, pledge,
hypothecate or otherwise dispose of the Option or of such rights contrary to the
provisions hereof, or upon the levy of any attachment or

                                       4
<PAGE>

similar process upon the Option or such rights, the Option and such rights
shall, at the election of the Company, become null and void.

            7. No Special Employment Rights. Nothing contained in the Plan or
this Agreement shall be construed or deemed by any person under any
circumstances to bind the Company or any Parent Corporation or Subsidiary to
continue the employment of the Associate for the period within which the Option
may be exercised. Moreover, during the period of the Associate's employment, the
Associate shall render diligently and faithfully the services which are assigned
to the Associate from time to time by the Board of Directors or by the executive
officers of the Company or any Parent Corporation or Subsidiary and shall at no
time take any action which directly or indirectly would be inconsistent with the
best interests of the foregoing entities.

            8. Rights as a Shareholder. The Associate shall have no rights as a
Shareholder with respect to any Shares which may be purchased by exercise of the
Option unless and until a certificate representing such Shares is duly issued
and delivered to the Associate. No adjustment shall be made for dividends or
other rights for which the record date is prior to the date such stock
certificate is issued except as provided for in Sections 9 or 10 of this
Agreement.

            9. Recapitalization. In the event that the outstanding shares of
Common Stock of the Company are changed into or exchanged for a different number
or kind of shares or other securities of the Company by reason of any
recapitalization, reclassification, stock split, stock dividend, combination or
subdivision, appropriate adjustment shall be made in the number and kind of
Shares to which the Option shall be exercisable. Such adjustment to the Option
shall be made without change in the total price applicable to the unexercised
portion of the Option, and a corresponding adjustment in the Exercise Price per
Share shall be made. No such adjustment shall be made which would, within the
meaning of any applicable provisions of the Code, constitute a modification,
extension or renewal of the Option or a grant of additional benefits to the
Associate.

            10. Reorganization of the Company. In case (i) the Company is merged
or consolidated with another corporation and the Company is not the surviving
corporation, (ii) all or substantially all of the assets or more than 50% of the
outstanding voting stock of the Company is acquired by any other corporation or
(iii) the Company is reorganized or liquidated prior to the Expiration Date, the
Board of Directors of the Company, or the board of directors of any corporation
assuming the obligations of the Company, shall, as to the Option, either (x)
make appropriate provision for the protection of the Option by the substitution
on an equitable basis of appropriate stock of the Company, or of the merged,
consolidated or otherwise reorganized corporation which will be issuable in
respect of the shares of Common Stock of the Company, provided that no
additional benefits shall be conferred upon the Associate as a result of such
substitution, and the excess of the aggregate fair market value of the Shares
subject to the

                                       5
<PAGE>

Option immediately after such substitution over the purchase price thereof is
not more than the excess of the aggregate fair market value of the Shares
subject to the Option immediately before such substitution over the purchase
price thereof, or (y) upon written notice to the Associate, provide that the
Option must be exercised within a specified number of days of the date of such
notice or they will be terminated.

            11.   Withholding Taxes.  The Company's obligation to deliver
Shares upon the exercise of the Option shall be subject to the Associate's
satisfaction of all applicable federal, state and local income and employment
tax withholding requirements.

            12.   Investment Representations; Legend.

                  (a)   Representations.  As of the time of any exercise of
the Option, the Associate represents, warrants and covenants to the Company
that:

                        (i)   Any Shares purchased upon exercise of the
Option shall be acquired for the Associate's account for investment only and not
with a view to, or for sale in connection with, any distribution of the Shares
in violation of the Securities Act of 1933, as amended (the "Securities Act"),
or any rule or regulation thereunder.

                        (ii)  The Associate is an "accredited investor" as
such  term is defined in Regulation D promulgated under the Securities Act.

                        (iii) The Associate has had such opportunity as he or
she has deemed adequate to obtain from representatives of the Company such
information as is necessary to permit the Associate to evaluate the merits and
risks of an investment in the Company.

                        (iv)  The Associate is able to bear the economic risk
of holding such Shares for an indefinite period.

                        (v)   The Associate understands that (A) the Shares
will not be registered under the Securities Act and are "restricted securities"
within the meaning of Rule 144 under the Securities Act; (B) the Shares cannot
be sold, transferred or otherwise disposed of unless they are subsequently
registered under the Securities Act or an exemption from registration is then
available; (C) in any event, the exemption from registration under Rule 144 will
not be available for at least one year and even then will not be available
unless a public market then exists for the Company's Common Stock, adequate
information concerning the Company is then available to the public, and other
terms and conditions of Rule 144 are complied with; and (D) the Company has no
obligation or current intention to register any Shares acquired pursuant to the
exercise of the Option under the Securities Act.

                                       6
<PAGE>

                  (b)   Tax Consequences.  The Associate hereby represents
that the Associate has obtained appropriate legal or tax advice with respect
to the tax consequences to the Associate of exercising the Option and selling
the Shares.

                  (c) Legend on Stock Certificates. All stock certificates
representing Shares issued to the Associate upon exercise of the Option shall
have affixed thereto legends substantially in the following form, in addition to
any other legends required by applicable state law:

            THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
            UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
            SECURITIES LAWS AND MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED,
            HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1)
            REGISTRATION IN COMPLIANCE WITH SAID ACT AND SUCH STATE LAWS, OR (2)
            AN OPINION OF COUNSEL FOR THE COMPANY TO THE EFFECT THAT SUCH
            DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF ANY RELEVANT FEDERAL
            OR STATE SECURITIES LAWS.

            THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF
            FIRST REFUSAL CONTAINED IN A STOCK OPTION AGREEMENT BETWEEN THE
            COMPANY AND THE HOLDER HEREOF. A COPY OF SUCH AGREEMENT IS ON FILE
            AT THE PRINCIPAL OFFICES OF THE COMPANY.

            By making payment upon exercise of the Option, the Associate shall
be deemed to have reaffirmed, as of the date of such payment, the
representations made in this Section 12.

            13.   Limitations on Dispositions of Incentive Stock Options.

                  (a) Prohibitions on Sales of Shares. It is understood and
intended that the Option shall qualify as an Incentive Stock Option.
Accordingly, the Associate understands that in order to obtain the benefits of
an incentive stock option under Section 421 of the Code, no sale or other
disposition may be made of any Shares acquired upon exercise of the Option
within the one year period beginning on the day after the day of the transfer of
such Shares to him or her, nor within the two-year period beginning on the day
after the date of this Agreement. If the Associate intends to dispose or does
dispose (whether by sale, exchange, gift, transfer or otherwise) of any such
Shares within said periods, he or she will notify the Company in writing within
ten days after such disposition.

                  (b) Maximum Number of Incentive Stock Options Exercisable
During One Year. To the extent that the aggregate fair market value (determined
as of

                                       7
<PAGE>

the time an option is granted pursuant to the Plan) of Common Stock with respect
to which an option exercisable for the first time by the Associate during any
calendar year under the Plan and all similar plans maintained by the Company
exceeds $100,000.00, options for such Common Stock shall be treated as options
that are not Incentive Stock Options. For purposes of this provision, Options
shall be taken into account in the order in which they were granted.

            14. Right of First Refusal. If the Associate wishes to sell or
otherwise transfer any of the Shares, then at least 30 days prior to any such
transfer, the Associate shall give notice to the Company (the "Notice"). The
Notice shall set forth (i) the number of Shares proposed to be sold or
transferred; (ii) the date or proposed date of the sale or transfer; (iii) the
identity of the proposed transferee; and (iv) the principal terms of the
transfer, including the cash or other property or consideration to be received
upon such transfer. The Company shall have the right, but not the obligation, to
purchase all, but not less than all, of the Shares on the same terms specified
in the Notice. Within 30 days after receipt of the Notice, the Company shall
give written notice (the "Company Notice") to the Associate stating whether or
not it elects to exercise its right to purchase the Shares and a date and time
for consummation of such purchase, not more than 10 days after the receipt by
the Associate of the Company Notice. Failure by the Company to deliver a Company
Notice within such time period shall be deemed an election by the Company not to
exercise its right to purchase the Shares. If the Company does not exercise its
right to purchase the Shares, then the Associate shall be free to transfer the
Shares on the terms provided in the Notice. Any Shares not purchased within a
period of 90 days of the Notice by the proposed transferee in the Notice may not
be sold or otherwise disposed of until they are again offered to the Company
under the procedures specified in this Section 14. The Company's right of first
refusal described in this Section 14 shall terminate upon the closing of an
initial public offering of the Company's Common Stock.

            15.   Miscellaneous.

                  (a) This Agreement and any instruments delivered pursuant to
this Agreement shall be construed, interpreted and governed in accordance with
the laws of the State of New Jersey, without regard to the conflicts of law
rules thereof.

                  (b) Any claim or controversy arising out of, or relating to,
this Agreement, other than with respect to the Confidentiality Agreement,
between Employee and the Company (or any officer, director, employee or agent of
the Company), or the breach thereof, shall be settled by arbitration
administrated by the American Arbitration Association under its National Rules
for the Resolution of Employment Disputes. Such arbitration shall be held in New
Jersey (or in such other location as the Company may at the time be
headquartered). The arbitration shall be conducted before a three-member panel.
Within fifteen (15) days after the commencement of arbitration, each party shall
select one person to act as arbitrator and the two selected shall select a third
arbitrator

                                       8
<PAGE>

within ten (10) days of their appointment. If the arbitrators selected by the
parties are unable or fail to agree upon the third arbitrator, the third
arbitrator shall be selected by the American Arbitration Association and shall
be a member of the bar of the State of New Jersey actively engaged in the
practice of employment law for at least ten years. The arbitration panel shall
apply the substantive laws of the State of New Jersey in connection with the
arbitration and the New Jersey Rules of Evidence shall apply to all aspects of
the arbitration. The award shall be made within thirty days of the closing of
the hearing. Judgment upon the award rendered by the arbitrator(s) may be
entered by any court having jurisdiction thereof.

                  (c) This Agreement shall extend to, be binding upon and inure
to the benefit of the Associate, his legal representatives, his heirs,
successors and assigns (subject, however, to the limitations set forth herein
with respect to the assignment of the Option or rights herein) and upon the
Company, its successors and assigns regardless of any change in the business
structure of the Company, be it through spinoff, merger, sale of stock, sale of
assets or any other transaction and shall be construed in a manner that is
consistent with the provisions of the Plan.

                  (d) This Agreement contains the entire agreement of the
parties with respect to the subject matter hereof. No waiver, modification or
change of any provision of this Agreement shall be valid unless in writing and
signed by both parties.

                  (e) The waiver of any breach of any duty, term or condition of
this Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

                  (f) All notices pursuant to this Agreement will be in writing
and will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the parties
hereto at the addresses set forth beneath their names on the signature page
hereto or to such other addresses as may hereafter be specified by like notice
in writing by either of the parties, and will be deemed given (i) upon receipt
if by personal delivery, (ii) on the day on which delivered if delivered by
telecopier (with confirmation of receipt (such receipt to be established by
acceptable protocol)), (iii) upon mailing if sent by registered or certified
mail or (iv) when transmitted if delivered by electronic mail (with satisfactory
evidence of transmittal (such evidence of transmittal to be established by
acceptable protocol)). Copies of all notices shall be sent to: Amicus
Therapeutics, Inc., 6 Cedarbrook Drive, Cranbury, NJ 08512.

                  (g) The headings of the sections of this Agreement are
inserted for convenience of reference only and will not be deemed to constitute
a part hereof or to affect the meaning hereof.

                                       9
<PAGE>

                  (h) This Agreement may be executed in counterparts, each of
which shall be deemed an original but all of which shall together constitute one
and the same Agreement.

Date of Grant:                           Amicus Therapeutics, Inc.

February 28, 2006                        By:
                                            -----------------------------------
                                            John F. Crowley
                                            Chairman & CEO

                                         Address: 6 Cedar Brook Drive
                                                  Cranbury, NJ 08512

                             ASSOCIATE'S ACCEPTANCE

      The undersigned hereby accepts the foregoing Agreement and agrees to the
terms and conditions thereof. The undersigned hereby acknowledges receipt of a
copy of the Company's 2002 Equity Incentive Plan.

                                        ASSOCIATE

                                        ---------------------------------------
                                        Name: NAME
                                        Address:

                                        SSN#:

                                       10
<PAGE>

                            AMICUS THERAPEUTICS, INC.

                      NON-QUALIFIED STOCK OPTION AGREEMENT

      1. Grant of Option. Amicus Therapeutics, Inc., a Delaware corporation (the
"Company"), hereby grants to XXX (the "Associate"), an option (the "Option"),
pursuant to the Company's 2002 Equity Incentive Plan (the "Plan"), to purchase
up to an aggregate of XXX shares (the "Shares") of Common Stock, $.01 par value
("Common Stock"), of the Company at a price of $XX per Share (the "Exercise
Price"), purchasable as set forth in and subject to the terms and conditions of
this Agreement and the Plan.

      2. Exercise of Option and Provisions for Termination.

            (a) Exercisability of Option. The Option shall become exercisable as
follows: Beginning on XX and on the first day of each calendar month thereafter,
the shares shall vest and become exercisable in XX equal monthly installments of
XX shares.

            (b) The periods of time following the Associate's cessation of
service during which the Option remains outstanding shall not be included for
purposes of determining the exercisability of the Option under this subsection
(a).

            (c) Expiration Date. Except as otherwise provided in this Agreement,
the Option may not be exercised after the date (hereinafter the "Expiration
Date") that is the fifth anniversary of the date of grant set forth on the
signature page hereof.

            (d) Exercise Procedure. Subject to the conditions set forth in this
Agreement, the Option shall be exercised by the Associate's delivery of written
notice of exercise to the chief financial officer of the Company, specifying the
number of Shares to be purchased and the aggregate Exercise Price to be paid
therefor, accompanied by payment in full in accordance with Section 3. Such
exercise shall be effective upon receipt by the chief financial officer of the
Company of such written notice together with the required payment. The Associate
may purchase less than the total number of Shares covered hereby, provided that
no partial exercise of the Option may be for any fractional Share or for less
than ten whole Shares.

      3. Payment of Exercise Price. Payment of the aggregate Exercise Price for
Shares purchased upon exercise of the Option shall be made by delivery to the
Company of cash or a check to the order of the Company.

      4. Delivery of Shares. The Company shall, upon payment of the aggregate
Exercise Price for the number of Shares purchased and paid for, make prompt
delivery of such Shares to the Associate, provided that if any law or regulation
requires the Company to take any action with respect to such Shares before the
issuance thereof, then the date of

<PAGE>

delivery of such Shares shall be extended for the period necessary to complete
such action. No Shares shall be issued and delivered upon exercise of the Option
unless and until, in the opinion of counsel for the Company, any applicable
registration requirements of the Securities Act of 1933, as amended (the
"Securities Act"), any applicable listing requirements of any national
securities exchange on which stock of the same class is then listed, and any
other requirements of law or of any regulatory bodies having jurisdiction over
such issuance and delivery, shall have been fully complied with.

      5. Non-transferability of Option. Except as otherwise agreed to by the
Board of Directors or a committee thereof, the Option is personal and no rights
granted hereunder may be transferred, assigned, pledged or hypothecated in any
way (whether by operation of law or otherwise) nor shall any such rights be
subject to execution, attachment or similar process. Upon any attempt to
transfer, assign, pledge, hypothecate or otherwise dispose of the Option or of
such rights contrary to the provisions hereof, or upon the levy of any
attachment or similar process upon the Option or such rights, the Option and
such rights shall, at the election of the Company, become null and void.

      6. Rights as a Shareholder. The Associate shall have no rights as a
shareholder with respect to any Shares which may be purchased by exercise of the
Option unless and until a certificate representing such Shares is duly issued
and delivered to the Associate. No adjustment shall be made for dividends or
other rights for which the record date is prior to the date such stock
certificate is issued except as provided for in Sections 7 or 8 of this
Agreement.

      7. Recapitalization. In the event that the outstanding shares of Common
Stock of the Company are changed into or exchanged for a different number or
kind of shares or other securities of the Company by reason of any
recapitalization, reclassification, stock split, stock dividend, combination or
subdivision, appropriate adjustment shall be made in the number and kind of
Shares to which the Option shall be exercisable. Such adjustment to the Option
shall be made without change in the total price applicable to the unexercised
portion of the Option, and a corresponding adjustment in the Exercise Price per
Share shall be made. No such adjustment shall be made which would, within the
meaning of any applicable provisions of the Code, constitute a modification,
extension or renewal of the Option or a grant of additional benefits to the
Associate.

      8. Reorganization of the Company. In case (i) the Company is merged or
consolidated with another corporation and the Company is not the surviving
corporation, (ii) all or substantially all of the assets or more than 50% of the
outstanding voting stock of the Company is acquired by any other corporation or
(iii) the Company is reorganized or liquidated prior to the Expiration Date, the
Board of Directors of the Company, or the board of directors of any corporation
assuming the obligations of the Company, shall, as to the Option, either (x)
make appropriate provision for the protection of the Option by the substitution
on an equitable basis of appropriate stock of the Company, or of the

                                       2
<PAGE>

merged, consolidated or otherwise reorganized corporation which will be issuable
in respect of the shares of Common Stock of the Company, provided that no
additional benefits shall be conferred upon the Associate as a result of such
substitution, and the excess of the aggregate fair market value of the Shares
subject to the Option immediately after such substitution over the purchase
price thereof is not more than the excess of the aggregate fair market value of
the Shares subject to the Option immediately before such substitution over the
purchase price thereof, or (y) upon written notice to the Associate, provide
that the Option must be exercised within a specified number of days of the date
of such notice or they will be terminated. In any such case, the Board of
Directors may, in its discretion, accelerate the exercise dates of the Option.

      9. Withholding Taxes. The Company's obligation to deliver Shares upon the
exercise of the Option shall be subject to the Associate's satisfaction of all
applicable federal, state and local income and employment tax withholding
requirements.

      10. Investment Representations; Legend.

            (a) Representations. As of the time of any exercise of the Option,
the Associate represents, warrants and covenants to the Company that:

                  (i) Any Shares purchased upon exercise of the Option shall be
acquired for the Associate's account for investment only and not with a view to,
or for sale in connection with, any distribution of the Shares in violation of
the Securities Act, or any rule or regulation thereunder.

                  (ii) The Associate is an "accredited investor" as such term is
defined in Regulation D promulgated under the Securities Act.

                  (iii) The Associate has had such opportunity as he or she has
deemed adequate to obtain from representatives of the Company such information
as is necessary to permit the Associate to evaluate the merits and risks of an
investment in the Company.

                  (iv) The Associate is able to bear the economic risk of
holding such Shares for an indefinite period.

                  (v) The Associate understands that (A) the Shares will not be
registered under the Securities Act and are "restricted securities" within the
meaning of Rule 144 under the Securities Act; (B) the Shares cannot be sold,
transferred or otherwise disposed of unless they are subsequently registered
under the Securities Act or an exemption from registration is then available;
(C) in any event, the exemption from registration under Rule 144 will not be
available for at least one year and even then will not be available unless a
public market then exists for the Company's Common Stock, adequate information
concerning the Company is then available to the public, and other terms and
conditions of Rule 144 are complied with; and (D) the Company has no

                                       3
<PAGE>

obligation or current intention to register any Shares acquired pursuant to the
exercise of the Option under the Securities Act.

            (b) Tax Consequences. The Associate hereby represents that the
Associate has obtained appropriate legal or tax advice with respect to the tax
consequences to the Associate of exercising the Option and selling the Shares.

            (c) Legend on Stock Certificates. All stock certificates
representing Shares issued to the Associate upon exercise of the Option shall
have affixed thereto legends substantially in the following form, in addition to
any other legends required by applicable state law:

            THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
            UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE
            SECURITIES LAWS AND MAY NOT BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED,
            HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1)
            REGISTRATION IN COMPLIANCE WITH SAID ACT AND SUCH STATE LAWS, OR (2)
            AN OPINION OF COUNSEL FOR THE COMPANY TO THE EFFECT THAT SUCH
            DISPOSITION WOULD NOT CONSTITUTE A VIOLATION OF ANY RELEVANT FEDERAL
            OR STATE SECURITIES LAWS.

            THE SHARES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
            RIGHTS OF FIRST REFUSAL CONTAINED IN A STOCK OPTION AGREEMENT
            BETWEEN THE COMPANY AND THE HOLDER HEREOF. A COPY OF SUCH AGREEMENT
            IS ON FILE AT THE PRINCIPAL OFFICES OF THE COMPANY.

            By making payment upon exercise of the Option, the Associate shall
be deemed to have reaffirmed, as of the date of such payment, the
representations made in this Section 10.

      11. Right of First Refusal. If the Associate wishes to sell or otherwise
transfer any of the Shares, then at least 30 days prior to any such transfer,
the Associate shall give notice to the Company (the "Notice"). The Notice shall
set forth (i) the number of Shares proposed to be sold or transferred; (ii) the
date or proposed date of the sale or transfer; (iii) the identity of the
proposed transferee; and (iv) the principal terms of the transfer, including the
cash or other property or consideration to be received upon such transfer. The
Company shall have the right, but not the obligation, to purchase all, but not
less than all, of the Shares on the same terms specified in the Notice. Within
30 days after receipt of the Notice, the Company shall give written notice (the
"Company Notice") to the Associate stating whether or not it elects to exercise
its right to purchase the Shares and a date and time for consummation of such
purchase, not more than 10 days after the receipt by the Associate of the
Company Notice. Failure by the Company

                                       4
<PAGE>

to deliver a Company Notice within such time period shall be deemed an election
by the Company not to exercise its right to purchase the Shares. If the Company
does not exercise its right to purchase the Shares, then the Associate shall be
free to transfer the Shares on the terms provided in the Notice. Any Shares not
purchased within a period of 90 days of the Notice by the proposed transferee in
the Notice may not be sold or otherwise disposed of until they are again offered
to the Company under the procedures specified in this Section 11. The Company's
right of first refusal described in this Section 11 shall terminate upon the
closing of an initial public offering of the Company's Common Stock.

      12. Miscellaneous.

            (a) This Agreement and any instruments delivered pursuant to this
Agreement shall be construed, interpreted and governed in accordance with the
laws of the State of New Jersey, without regard to the conflicts of law rules
thereof.

            (b) Any claim or controversy arising out of, or relating to, this
Agreement, other than with respect to any confidentiality agreement between
Associate and the Company (or any officer, director, employee or agent of the
Company), or the breach thereof, shall be settled by arbitration administrated
by the American Arbitration Association under its National Rules for the
Resolution of Employment Disputes. Such arbitration shall be held in New Jersey
(or in such other location as the Company may at the time be headquartered). The
arbitration shall be conducted before a three-member panel. Within fifteen (15)
days after the commencement of arbitration, each party shall select one person
to act as arbitrator and the two selected shall select a third arbitrator within
ten (10) days of their appointment. If the arbitrators selected by the parties
are unable or fail to agree upon the third arbitrator, the third arbitrator
shall be selected by the American Arbitration Association and shall be a member
of the bar of the State of New Jersey actively engaged in the practice of
employment law for at least ten years. The arbitration panel shall apply the
substantive laws of the State of New Jersey in connection with the arbitration
and the New Jersey Rules of Evidence shall apply to all aspects of the
arbitration. The award shall be made within thirty days of the closing of the
hearing. Judgment upon the award rendered by the arbitrator(s) may be entered by
any Court having jurisdiction thereof.

            (c) This Agreement shall extend to, be binding upon and inure to the
benefit of the Associate, his legal representatives, his heirs, successors and
assigns (subject, however, to the limitations set forth herein with respect to
the assignment of the Option or rights herein) and upon the Company, its
successors and assigns regardless of any change in the business structure of the
Company, be it through spinoff, merger, sale of stock, sale of assets or any
other transaction and shall be construed in a manner that is consistent with the
provisions of the Plan.

                                       5
<PAGE>

            (d) This Agreement contains the entire agreement of the parties with
respect to the subject matter hereof. No waiver, modification or change of any
provision of this Agreement shall be valid unless in writing and signed by both
parties.

            (e) The waiver of any breach of any duty, term or condition of this
Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

            (f) All notices pursuant to this Agreement will be in writing and
will be sent by personal delivery, telecopier, electronic mail or by prepaid
registered or certified mail, return receipt requested, addressed to the parties
hereto at the addresses set forth beneath their names on the signature page
hereto or to such other addresses as may hereafter be specified by like notice
in writing by either of the parties, and will be deemed given (i) upon receipt
if by personal delivery, (ii) on the day on which delivered if delivered by
telecopier (with confirmation of receipt (such receipt to be established by
acceptable protocol)), (iii) upon mailing if sent by registered or certified
mail or (iv) when transmitted if delivered by electronic mail (with satisfactory
evidence of transmittal (such evidence of transmittal to be established by
acceptable protocol)). Copies of all notices shall be sent to: Amicus
Therapeutics, Inc., 6 Cedar Brook Drive, Cranbury, NJ 08512, Attention: VP of
Human Resources and Leadership Development, Telecopier No. 609-662-2004.

            (g) The headings of the sections of this Agreement are inserted for
convenience of reference only and will not be deemed to constitute a part hereof
or to affect the meaning hereof.

            (h) This Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which shall together constitute one and
the same Agreement.

                                       6
<PAGE>

Date of Grant:  XXX                     Amicus Therapeutics, Inc.

                                        By:
                                           -------------------------------------
                                           Name:      XX

                                          Title:     XX

                                        Address:   6 Cedar Brook Drive
                                                   Cranbury, NJ 08512

                             ASSOCIATE'S ACCEPTANCE

      The undersigned hereby accepts the foregoing Agreement and agrees to the
terms and conditions thereof. The undersigned hereby acknowledges receipt of a
copy of the Company's 2002 Equity Incentive Plan.

                                        ASSOCIATE

                                        ----------------------------------------
                                        Name:   XX
                                        Address:

                                        SSN:<PAGE>
                                                                   Exhibit 10.19

                              EMPLOYMENT AGREEMENT

               THIS EMPLOYMENT AGREEMENT (the "Agreement"), dated as of
September 11, 2006, between AMICUS THERAPEUTICS, INC., a Delaware corporation
having an office at 6 Cedar Brook Drive, Cranbury, New Jersey 08512 (the
"Company"), and DONALD J. HAYDEN, an individual residing at 9 Larkspur Lane,
Newtown, Pennsylvania 18940 ("Employee").

                                    PREAMBLE

               WHEREAS, the Employee has served as Chairman of the Board of
Directors of the Company since February 28, 2006 and to date has provided no
services to the Company other than service as Chairman;

               WHEREAS, the Company's President and Chief Executive Officer has
been called to active duty military service for a period anticipated to end
February 23, 2007;

               WHEREAS, the Company desires to engage Employee to serve in the
capacities of Interim President and Chief Executive Officer in addition to his
service as Chairman of the Board of Directors and Employee desires to perform
the duties of such offices, all pursuant to the terms and conditions hereinafter
set forth;

               NOW, THEREFORE, in consideration of the mutual covenants
contained herein, and for other good and valuable consideration, the sufficiency
and receipt whereof is hereby acknowledged, the parties agree as follows:

     SECTION 1.     Employment.

               1.1  Duties. Subject to the terms and conditions of this
Agreement, Employee is hereby employed by the Company to serve as its Interim
President and Chief Executive Officer. Employee accepts such employment, and
agrees to discharge all of the duties normally associated with the positions of
Interim President and Chief Executive Officer, to faithfully and to the best of
his abilities perform such other services consistent with his position as a
senior executive officer as may from time to time be assigned to him by the
Board of Directors of the Company and to devote all of his skill and attention
to such services. Notwithstanding the foregoing, however, Employee may serve on
the boards of directors of other companies, and in civic, cultural,
philanthropic and professional organizations so long as such service does not
detract from the performance of Employee's duties hereunder, such determination
to be made by the Board of Directors in its sole discretion. At all times during
which Employee remains Interim President and Chief Executive Officer of the
Company, Employee shall serve, at the request of the Company's Board of
Directors, as an officer or director of any Company affiliate without additional
remuneration therefor. Employee also serves as Chairman of the Board of
Directors of the Company, but such service is not governed by the terms of this
Agreement.

               1.2  Time Commitment. Employee shall be present for duties at the
Company's principal offices no less than two (2) days per week (inclusive of
days in which Employee travels on reasonable and necessary Company business).

     SECTION 2.     Compensation and Benefits.

               2.1  Base Salary. During the Employment Term (as hereinafter
defined), the Company shall pay Employee a salary at the annual rate of $200,000
or such greater amount as the Company's Board of Directors may from time to time
establish pursuant to the terms hereof (the "Base
<PAGE>
Salary''). Such Base Salary may be increased, but not decreased, by the Board
of Directors of the Company in its sole discretion. The Base Salary shall be
payable in accordance with the Company's customary payroll practices for its
senior management personnel.

     2.2 Bonus. Upon successful completion of the Employment Term, Employee
shall be eligible to receive a bonus (the "Bonus") in such amount as determined
by the Board of Directors in its sole discretion.

     2.3 Benefits

          (a) Benefit Plans. During the Employment Term, Employee may
participate, on the same basis and subject to the same qualifications as other
senior management personnel of the Company, in any benefit plans (including
health and medical insurance of Employee, Employee's spouse and Employee's
dependents) and policies in effect with respect to senior management personnel
of the Company, including any stock option plan. Without limiting the
foregoing, at such time as the Company has increased the number of shares
authorized for grant under the Company's 2002 Equity Incentive Plan, Employee
shall be granted incentive stock options (the "Options") to purchase 100,000
shares of common stock at a purchase price of $1.09 per share. Subject to the
terms of Section 4 hereof, the Options shall vest in full at the end of the
Employment Term.

          (b) Reimbursement of Expenses. During the Employment Term, the
Company shall pay or promptly reimburse Employee, upon submission of proper
invoices in accordance with the Company's normal procedures, for all reasonable
out-of-pocket business, entertainment and travel expenses incurred by Employee
in the performance of his duties hereunder.

          (c) Vacation. During the Employment Term, Employee shall be entitled
to up to two (2) calendar weeks of vacation (inclusive of business days in
which Employee is not at the Company's principal offices or is not performing
Company duties) every six (6) months during the Employment Term in accordance
with the policies of the Company applicable to senior management personnel from
time to time. Vacation week(s), to the extent not used in the first six (6)
months, may be carried over to the second six (6) months. Unused vacation may
not extend to the Employment Term or result in additional compensation upon
termination of this Agreement.

          (d) Withholding. The Company shall be entitled to withhold from
amounts payable or benefits accorded to Employee under this Agreement all
federal, state and local income, employment and other taxes, as and in such
amounts as may be required by applicable law.

     SECTION 3. Employment Term. The term of this Agreement (the "Employment
Term") shall commence on the date of this Agreement and shall terminate on the
earlier to occur of: (a) the close of business on the day John F. Crowley's
active duty military service terminates; or (b) September 11, 2007. Employee's
employment hereunder shall be coterminous with the Employment Term, unless
sooner terminated as provided in Section 4.

     SECTION 4. Termination; Severance Benefits.

     4.1 Generally. Either the Board of Directors of the Company or Employee
may terminate Employee's employment hereunder, for any reason, at any time
prior to the expiration of the Employment Term, upon thirty (30) days prior
written notice to the other party. Termination of Employee's employment
hereunder for any reason shall have no effect on Employee's status as Chairman
of the Board of Directors of the Company. Such termination shall,
however, result in an automatic

                                      -2-
<PAGE>
termination of Employee's service in any other position or office he may at the
time hold with the Company or any of its affiliates.

     4.2 Termination by Employee. If, prior to the expiration of the Employment
Term, Employee voluntarily resigns from his employment, Employee shall (i)
receive no further Base Salary or Bonus hereunder, other than accrued and
unpaid Base Salary through and including the effective date of termination of
his employment with the Company (the "Accrued Compensation") and (ii) cease to
be covered under or be permitted to participate in or receive any of the
benefits described in Section 2.3 hereof (provided, however, that Employee
shall be entitled to receive any benefits under Section 2.3 hereof to the
extent such benefits have accrued through and including the effective date of
termination of his employment with the Company).

     4.3 Termination by the Company.

          (a) Without Cause. If, prior to the expiration of the Employment
Term, the Company terminates Employee's employment hereunder without Cause,
then Employee shall be entitled to receive the Severance Payment commencing upon
the effective date of the termination of Employee's employment with the
Company, shall be entitled to receive (on such effective date of termination)
benefits under Section 2.3(b) hereof to the extent such benefits have accrued
through and including such effective date of termination and shall continue to
be covered under or be permitted to participate in or receive the benefits
described in Section 2.3(a) hereof for the period of time during which the
Severance Payment is payable to Employee. In addition, the Options shall vest
in full on the date of Employee's effective date of termination and Employee
shall continue to be covered under or be permitted to participate in or receive
applicable Benefits for the period of time during which the Severance Payment
is payable to Employee. "Cause", as used in this Agreement, means for any of
the following reasons: (i) willful or deliberate misconduct by Employee that
materially damages the Company; (ii) misappropriation of Company assets; (iii)
Employee's conviction of or a plea of guilty or "no contest" to, a felony; or
(iv) any willful disobedience of the lawful and unambiguous instructions of the
Board of Directors of the Company; provided that the Board of Directors has
given Employee thirty (30) days written notice of such disobedience or neglect
and Employee has failed to cure such cause.

          (b) For Cause. If, prior to the expiration of the Employment Term,
the Company terminates Employee's employment hereunder for Cause, Employee
shall (i) receive no further Base Salary or Bonus hereunder, other than Accrued
Compensation which shall be payable on the effective dated of the termination
of Employee's employment with the Company and (ii) cease to be covered under or
be permitted to participate in or receive any of the benefits described in
Section 2.3 hereof; provided, however, that (A) Employee shall be entitled to
receive (on such effective date of termination) any benefits under Section 2.3
hereof to the extent such benefits have accrued through and including such
effective date of termination, and (B) if Employee is terminated for Cause
hereunder solely as a result of being convicted of a felony, which conviction
is ultimately reversed on appeal or pardoned, Employee shall be deemed to have
been terminated without Cause as of the date of such termination for Cause.

     4.4 Termination upon Death or Disability. Employee's employment hereunder
shall terminate upon death of Employee. The Company may terminate Employee's
employment hereunder in the event Employee is disabled and such disability
continues for more than 180 days. "Disability" shall be defined as the
inability to render the services required of him, with or without a reasonable
accommodation, under this Agreement as a result of physical or mental
incapacity. In the event of death or termination by the Company due to
disability of the Employee, the Company shall continue to pay to Employee or
Employee's estate, as the case may be, the compensation required under Section
2, for a period of two (2) months.

                                      -3-
<PAGE>
        4.5 Release Required. In order to receive the Severance Payment, and
other benefits under Section 4 hereof, including the acceleration of vesting of
the Options, Employee must execute and deliver to the Company a release, the
form and substance of which are acceptable to the Company.

    SECTION 5. General.

        5.1 Confidentiality and Non-Competition Agreement. Contemporaneously
herewith, Employee and the Company are entering into that certain
Confidentiality and Non-Competition Agreement (the "Confidentiality Agreement"),
the terms of which are incorporated herein by reference and made a part hereof.

        5.2 No Conflict. Employee represents and warrants that he has not
entered, nor will he enter, into any other agreements that restrict his ability
to fulfill his obligations under this Agreement and the Confidentiality
Agreement.

        5.3 Governing Law. This Agreement shall be construed, interpreted and
governed by the laws of the State of New Jersey, without regard to the conflicts
of law rules thereof.

        5.4 Binding Effect. This Agreement shall extend to and be binding upon
Employee, his legal representatives, heirs and distributees and upon the
Company, its successors and assigns regardless of any change in the business
structure of the Company.

        5.5 Assignment. Neither this Agreement nor any of the rights or
obligations hereunder shall be assigned or delegated by any party without the
prior written consent of the other party.

        5.6 Entire Agreement. Except for any stock option or stock award
agreements between the parties and the Confidentiality Agreement, this Agreement
contains the entire agreement of the parties with respect to the subject matter
hereof. No waiver, modification or change of any provision of this Agreement
shall be valid unless in writing and signed by both parties.

        5.7 Waiver. The waiver of any breach of any duty, term or condition of
this Agreement shall not be deemed to constitute a waiver of any preceding or
succeeding breach of the same or any other duty, term or condition of this
Agreement.

        5.8 Severability. If any provision of this Agreement shall be
unenforceable in any jurisdiction in accordance with its terms, the provision
shall be enforceable to the fullest extent permitted in that jurisdiction and
shall continue to be enforceable in accordance with its terms in any other
jurisdiction and the validity, legality and enforceability of the remaining
provisions contained herein shall not be affected thereby.

        5.9 Conflicting Agreements. In the event of a conflict between this
Agreement and any other agreement between Employee and the Company, the terms
and provisions of this Agreement shall control.

        5.10 Resolution of Disputes. Any claim or controversy arising out of, or
relating to, this Agreement, other than with respect to the Confidentiality
Agreement, between Employee and the Company (or any officer, director, employee
or agent of the Company), or the breach thereof, shall be settled by arbitration
administrated by the American Arbitration Association under its National Rules
for the Resolution of Employment Disputes. Such arbitration shall be held in New
Jersey (or in such other location as the Company may at the time be
headquartered). The arbitration shall be conducted before a three-member panel.
Within fifteen (15) days after the commencement of arbitration, each party shall

                                      -4-
<PAGE>
select one person to act as arbitrator and the two selected shall select a
third arbitrator within ten (10) days of their appointment.

        If the arbitrators selected by the parties are unable or fail to agree
upon the third arbitrator, the third arbitrator shall be selected by the
American Arbitration Association and shall be a member of the bar of the State
of New Jersey actively engaged in the practice of employment law for at least
ten years. The arbitration panel shall apply the substantive laws of the State
of New Jersey in connection with the arbitration and the New Jersey Rules of
Evidence shall apply to all aspects of the arbitration. The award shall be made
within thirty days of the closing of the hearing. Judgment upon the award
rendered by the arbitrators(s) may be entered by any Court having jurisdiction
thereof.

        5.11 Notices. All notices pursuant to this Agreement shall be in writing
and shall be sent by prepaid certified mail, return receipt requested or by
recognized air courier service addressed as follows:

                           (i)  If to the Company to:

                                Amicus Therapeutics, Inc.
                                6 Cedar Brook Drive
                                Cranbury, New Jersey 08512

                           (ii) If to Employee to:

                                Donald J. Hayden
                                9 Larkspur Lane
                                Newtown, Pennsylvania 18940

or to such other addresses as may hereinafter be specified by notice in writing
by either of the parties, and shall be deemed given three (3) business days
after the date so mailed or sent.

        5.12 Counterparts. This Agreement may be executed in counterparts, each
of which shall be deemed an original but all of which shall together constitute
one and the same agreement.

        IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

"EMPLOYEE":                                            /s/ DONALD J. HAYDEN
                                                       -------------------------
                                                       DONALD J. HAYDEN

"COMPANY":                                             AMICUS THERAPEUTICS, INC.

                                                       By: /s/ Matthew Patterson
                                                       -------------------------
                                                       Name: Matthew Patterson
                                                       -------------------------
                                                       Title: COO
                                                       -------------------------

                                      -5-

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