Document:

<PAGE>

[LOGO]
                                                                    Exhibit 10.1

                             BUSINESS LOAN AGREEMENT

     This Business Loan Agreement (this "Agreement") is entered into by and
between Comerica Bank-California ("Bank") and Interpore International, Inc., a
Delaware Corporation ("Borrower") as of this 14/th/ day of June, 2002, at
Bank's headquarters office at 333 West Santa Clara Street, San Jose, California
95113.

     1. Loans To Borrower. Bank and Borrower agree that any loans which Bank in
its sole discretion has made or may now or hereafter make to Borrower (sometimes
hereinafter collectively referred to as the "Loan") shall be subject to the
terms and conditions of this Agreement unless otherwise agreed to in writing by
Bank and Borrower. In the event there are contradictions between the provisions
of this Agreement and any other written agreement with the Bank, this Agreement
shall prevail. Loan shall be subject to the terms and conditions of this
Agreement, promissory note(s) executed in connection herewith and/or previously
or subsequently executed, and all amendments, renewals and extensions thereof
(singularly or collectively, the "Note"), and all those certain security
agreements and/or such other security or other documents as Bank has required or
may now or hereafter require in connection with the Loan (collectively, the
"Loan Documents").

     2. Legal Effect. This Agreement supplements the terms and conditions of the
Loan Documents. Except as otherwise specified herein, all terms used in this
Agreement shall have the same meaning as given in the Note and/or Loan Documents
which are incorporated herein by this reference. Any and all terms used in this
Agreement, the Note and/or the Loan Documents shall be construed and defined in
accordance with the meaning and definition of such term under and pursuant to
the California Uniform Commercial Code, as amended. Except as specifically
modified hereby, all of the terms and conditions of the Note and/or the Loan
Documents shall remain in full force and effect.

     3. Interest Rate; Payment Terms; Loan Fees. The principal and interest on
the Loan shall be payable on the terms set forth in the Note and/or the Loan
Documents. If applicable, a loan fee in the sum of Twenty Five Thousand Dollars
($25,000.00) shall be paid concurrently with the execution of this Agreement and
each anniversary of thereafter.

     4. Security. As security for Borrower's obligations to Bank under this
Agreement, the Note and/or the Loan Documents and all other indebtedness and
liabilities whatsoever of Borrower to Bank, whether direct or indirect, absolute
or contingent, due or to become due, now existing or hereafter arising,
evidenced by the Note and/or the Loan Documents (collectively, the
"Indebtedness"), Borrower hereby grants to Bank, prior to or simultaneously with
the borrowing hereunder, a continuing security interest of first priority,
subject only to Permitted Liens, in all accounts receivable, inventory,
equipment and intangibles (including but not limited to intellectual property)
and all proceeds thereof, and in all collateral provided to Bank pursuant to

<PAGE>

any security agreement and/or all collateral that is delivered to Bank and/or
which Bank possesses and all proceeds thereof, (collectively, the "Collateral").

     5. Representations and Warranties of Borrower. Borrower represents and
warrants to Bank that as of the date of acceptance of this Agreement, the Note
and/or the Loan Documents, as of the date of borrowing hereunder and at all
times the Loan or any other Indebtedness are outstanding hereunder:

        (a) Borrower is duly organized, validly existing and in good standing
under the laws of the State of Delaware;

        (b) Borrower has the legal power and authority to own its properties and
assets and to carry out its business as now being conducted; it is qualified to
do business in every jurisdiction except where the failure to be so qualified
would not reasonably be expected to have a Material Adverse Effect; it has the
legal power and authority to execute and perform this Agreement, the Note and/or
the Loan Documents, to borrow money in accordance with its terms, to execute and
deliver this Agreement, the Note and the Loan Documents, and to do any and all
other things required of it hereunder; and this Agreement, the Note and all the
Loan Documents, when executed on behalf of Borrower by its duly authorized
officers shall be its valid and binding obligations legally enforceable in
accordance with their terms, except as enforceability may be limited by
bankruptcy, insolvency, and similar laws and equitable principles affecting the
enforcement of creditors' rights generally;

        (c) The execution, delivery and performance of this Agreement, the Note
and/or the Loan Documents and the borrowings hereunder and thereunder (i) have
been duly authorized by all requisite corporate, partnership or company action;
(ii) do not require governmental approval; (iii) will not result (with or
without notice and/or the passage of time) in any conflict with or breach or
violation of or default under, any provision of law, the articles of
incorporation, articles of organization, operating agreement, bylaws or
partnership agreement of Borrower, any provision of any indenture, agreement or
other instrument to which Borrower is a party, or by which it or any of its
properties or assets are bound; and (iv) will not result in the creation or
imposition of any lien, charge or encumbrance of any nature whatsoever upon any
of the properties or assets of Borrower except in favor of Bank;

        (d) The consolidated balance sheet of Borrower and its subsidiaries as
provided to Bank in connection herewith as of March 31, 2002, and the related
consolidated statement of income of Borrower and its subsidiaries provided to
Bank for the three (3) month period ended March 31, 2002, fairly present the
financial condition of Borrower and its subsidiaries in accordance with
generally accepted accounting principles ("GAAP") consistently applied; and from
the date thereof to the date hereof, there has been no material adverse change
in such condition or operations; and

        (e) There is not pending nor, to the best of Borrower's knowledge,
threatened, any litigation, proceeding or governmental investigation which could
materially and adversely affect its business or its ability to perform its
obligations, pay the Indebtedness and/or comply with the covenants set forth
herein and/or in the Note and/or the other Loan Documents.

<PAGE>

     6. Affirmative Covenants. Until the Indebtedness is paid in full, Borrower
covenants and agrees to do the following:

        (a) Furnish to Bank within forty five (45) days after the end of each
quarter, an unaudited balance sheet and statement of income covering Borrower's
operations. Within ninety (90) days of the end of each of Borrower's fiscal
years, furnish to Bank statements of the financial condition of Borrower for
each such fiscal year, including but not limited to, a balance sheet, profit and
loss statement, and statement of cash flow. Said annual statements shall be
audited by an independent certified public accountant selected by Borrower and
reasonably acceptable to Bank;

        (b) [Intentionally Omitted];

        (c) Promptly inform Bank of the occurrence of any default or event of
default as defined in the Note and/or the Loan Documents (hereinafter referred
to as "Default") or of any event which could have a materially adverse effect
upon Borrower's business, properties, financial condition or ability to comply
with its obligations hereunder, including without limitation its ability to pay
the Indebtedness;

        (d) Furnish such other information as Bank may reasonably request;

        (e) Keep in full force and effect its own corporate existence in good
standing; continue to conduct and operate its business substantially as
presently conducted and operated and maintain and protect all franchises except
in each case as otherwise permitted with Bank's prior written approval which
shall not be unreasonably withheld or delayed; and preserve all the remainder of
its property used or useful in the conduct of its business and keep the same in
good repair and condition, normal wear and tear excepted;

        (f) Comply with the financial covenants set forth in Addendum A,
attached hereto and made a part hereof;

        (g) Maintain a standard and modern system of accounting in accordance
with GAAP consistently applied with ledger and account cards and/or computer
tapes and computer disks, computer printouts and computer records pertaining to
the Collateral which contain information as may from time to time be requested
by Bank, not modify or change its method of accounting without the written
consent of Bank first obtained, permit Bank and any of its employees, officers,
or agents, upon demand, during Borrower's usual business hours, or the usual
business hours of any third person having control thereof (upon three (3)
business days' notice unless an Event of Default has occurred and is continuing,
in which event no notice shall be required), to have access to and examine all
of Borrower's records relating to the Collateral, Borrower's financial condition
and the results of Borrower's operations and in connection therewith, permit
Bank or any of its agents, employees, or officer to copy and make extracts
therefrom;

        (h) [Intentionally Omitted];

        (i) Maintain Borrower's same place of business or chief executive office
as indicated below, and not relocate said address without giving Bank 30 days'
prior written notice;

<PAGE>

          (j) Maintain insurance with such insurers in such amounts and of a
type reasonably satisfactory to Bank, with Bank to be designated as the payee of
any such insurance policies under a payee/secured lender clause reasonably
acceptable to Bank; Bank hereby acknowledges that the amount and type of
Borrower's insurance policies as in effect on the date hereof, and Borrower's
present insurers, are all satisfactory to Bank; and

          (k) On a continuing basis from the date of this Agreement until the
Indebtedness is paid in full and Borrower has performed all of its other
obligations hereunder, Borrower represents and agrees that:

              (1) There are not and will not be Hazardous Materials (as later
defined) on, in or under any real or personal property ("Property") now or at
any time owned, occupied or operated by Borrower which in any manner violate any
Environmental Law (as later defined), except for such Hazardous Materials used
in the ordinary course of business in compliance with all applicable laws, rules
and regulations.

              (2) Borrower shall promptly conduct all investigations, testing
and other actions necessary to clean up and remove all Hazardous Materials on or
affecting the Property in accordance with every Environmental Law, except for
such Hazardous Materials used in the ordinary course of business in compliance
with all applicable laws, rules and regulations.

              (3) Borrower shall defend, indemnify and hold harmless Bank, its
employees, agents, officers, shareholders and directors from and against any and
all claims, damages, fines, expenses, liabilities or causes of action of
whatever kind, including without limit consultant fees, legal expenses and
reasonable attorneys' fees, suffered by any of them as a direct or indirect
result of any actual or asserted violation of any Environmental Law, except as
may be caused solely by Bank's gross negligence or willful misconduct.

              (4) Upon ten days notice to Borrower (except in an emergency),
Bank may (but is not obligated to) enter on the Property or take such other
actions as it reasonably deems appropriate to inspect, test for, clean up,
remove or minimize the impact of any Hazardous Materials upon Bank's receipt of
any notice from any source asserting the existence of any Hazardous Materials in
violation of any Environmental Law. All costs and expenses so incurred by Bank,
including without limit consultant fees, legal expenses and reasonable
attorneys' fees, shall be payable by Borrower upon demand.

              (5) The provisions of this section shall survive the repayment of
the Indebtedness, the satisfaction of all other obligations of Borrower to Bank,
the discharge or termination by Bank of any lien or security interest from
Borrower, and the foreclosure of or exercise of rights as to any collateral
given to Bank.

              (6) "Hazardous Materials" mean all of the following: any asbestos,
petroleum, petroleum by-products, flammable explosives, or radioactive materials
or any hazardous or toxic materials as defined in the Comprehensive
Environmental Response, Compensation and Liability Act of 1980, as amended (42
U.S.C. Sections 9601 et seq.) or in any other Environmental Law.

<PAGE>

              (7) "Environmental Law" means any federal, state, local or other
law, ordinance, statute, directive, rule, order or regulation the purpose of
which is to regulate or improve the environment or employee health and safety.

     7. Negative Covenants. Borrower shall not do any of the following:

        (a) Grant a security interest in or permit a lien, claim or encumbrance
upon any of the Collateral to any person, association, firm, corporation,
entity, governmental agency or instrumentality, other than Permitted Liens;

        (b) Permit any levy, attachment or restraint to be made affecting any of
Borrower's assets valued in the aggregate in excess of $500,000;

        (c) Permit any judicial officer or assignee to be appointed or to take
possession of any of Borrower's assets valued in the aggregate in excess of
$500,000;

        (d) Without Bank's prior written consent which shall not be unreasonably
withheld or delayed, change its business structure, corporate identity or
structure;

        (e) Move or relocate any collateral except in the ordinary course of
Borrower's business or as otherwise permitted hereunder;

        (f) Enter into any material transaction not in the usual course of
Borrower's business;

        (g) Make any change in Borrower's financial structure or in any of its
business objects, purposes or operations which would have a Material Adverse
Effect;

        (h) Incur any debt outside the ordinary course of Borrower's business;

        (i) Make loans, advances or extensions of credit to any person, except
for (i) sales on open account and otherwise in the ordinary course of business,
and (ii) loans and advances to employees of Borrower in the ordinary course of
business not to exceed $500,000 in the aggregate outstanding at any time;

        (j) Guaranty or otherwise, directly or indirectly, in any way be or
become responsible for obligations of any other person, whether by agreement to
purchase the indebtedness of any other person, agreement for the furnishing of
funds to any other person through the furnishing of goods, supplies or services,
by way of stock purchase, capital contribution, advance or loan, for the purpose
of paying and discharging (or causing the payment or discharge of) the
indebtedness of any other person, or otherwise, except for (i) the endorsement
of negotiable instruments by Borrower in the ordinary course of business for
deposit or collection, and (ii) guarantees of the trade or contractual
obligations of Borrower's subsidiaries in the ordinary course of business;

        (k) Sell, lease, move, transfer or otherwise dispose of properties and
assets having an aggregate book value of more than Three Million Dollars
($3,000,000.00) (whether in one transaction or in a series of transactions)
except as to the sale of the inventory in the ordinary

<PAGE>

course of business; change its name, liquidate, or consolidate with or merge
into any corporation; or without Bank's prior written consent which shall not be
unreasonably withheld or delayed, permit another corporation to merge into it,
acquire all or substantially all of the properties or assets of any other
person, enter into any reorganization or recapitalization or reclassify its
capital stock, or enter into any sale-lease back transaction;

          (l) Purchase or hold beneficially any stock or other securities of, or
make any investment or acquire any interest whatsoever in, any other person,
except for (i) the common stock of the subsidiaries owned by Borrower on the
date of this Agreement or other applicable date and (ii) Permitted Investments;

          (m) Allow any fact, condition or event to occur or exist with respect
to any employee, pension or profit sharing plan established or maintained by it
which would reasonably be expected to constitute grounds for termination of any
such plan or for the court appointment of a trustee to administer any such plan;
or

          (n) Without Bank's prior written consent, acquire or expend for or
commit itself to acquire or expend for fixed assets by lease, purchase or
otherwise in an aggregate amount that exceeds Five Million Dollars
($5,000,000.00) in any fiscal year.

     8.   Default. The terms "Default" or "Event of Default", as used herein,
shall have the meaning given in the Note and/or the Loan Documents. In addition,
the parties agree that any one or more of the following events shall constitute
a default by Borrower under this Agreement, the Note and/or the Loan Documents:

          (a) If Borrower fails or neglects to perform, keep or observe any
term, provision, condition, covenant, agreement, warranty or representation
contained in this Agreement, the Note, the Loan Documents or any other present
or future agreement between Borrower and Bank (other than those covenants and
agreements described in Sections 8(c) and 8(d) hereof), and such failure
continues for fifteen (15) days after the earlier to occur of (i) Borrower
obtaining knowledge of such failure or (ii) Bank's dispatch of notice to
Borrower of such failure;

          (b) If any material representation, statement, report or certificate
made or delivered by Borrower, or any of its officers, employees or agents to
Bank is not true and correct in all material respects;

          (c) If Borrower fails to pay when due and payable, or declared due and
payable, any principal payment due on the Indebtedness, or if Borrower fails to
pay on or before the third (3rd) calendar day following when due and payable, or
declared due and payable, any other payment due on the Indebtedness (whether for
interest, fees, taxes, reimbursement of Bank expenses, or otherwise);

          (d) If Borrower fails or neglects to perform, keep or observe any
term, provision, condition, covenant, agreement, warranty or representation
contained in Section 6(a), 6(f), or 6(i), or Section 7, of this Agreement;

          (e) If any Material Adverse Effect shall occur or exist;

<PAGE>

          (f) If there is any loss, theft, damage or destruction to or of any
assets of Borrower valued in the aggregate in excess of $1,000,000 over
applicable insurance coverage, or if any of Borrower's assets valued in the
aggregate in excess of $1,000,000 over applicable insurance coverage, are
affected, become subject to a writ or distress warrant, or are levied upon, or
come into the possession of any judicial officer or assignee and the same are
not released, discharged or bonded against within thirty (30) days thereafter;

          (g) If any insolvency, bankruptcy or other proceeding is filed or
commenced by Borrower or any Guarantor under any state or federal bankruptcy or
insolvency laws seeking its reorganization, dissolution or liquidation or
seeking the appointment of a receiver, trustee, court appointee, sequestrator or
otherwise, for all or any part of the property of Borrower or any Guarantor; or
the sale or other disposition by Borrower or any Guarantor in one or a series of
transaction of all of its assets or property; or the voluntary suspension of the
transaction of business by Borrower or any Guarantor; or the occurrence of
dissolution, termination of existence, merger, consolidation, business failure,
or assignment for the benefit of creditors of or by Borrower or any Guarantor;

          (h) If any insolvency, bankruptcy or other proceeding is filed or
commenced against Borrower or any Guarantor under any state or federal
bankruptcy or insolvency laws seeking its reorganization, dissolution or
liquidation or seeking the appointment of a receiver, trustee, court appointee,
sequestrator or otherwise, for all or any part of the property of Borrower or
any Guarantor, without being dismissed within forty-five (45) days of its
commencement;

          (i) If Borrower is enjoined, restrained or in any way prevented by
court order from continuing to conduct all or any material part of its business
affairs;

          (j) If a notice of lien (other than a Permitted Lien), levy or
assessment is filed of record with respect to any of Borrower's assets valued in
the aggregate in excess of $1,000,000 by the United States Government, or any
department, agency or instrumentality thereof, or by any state, county,
municipal or other government agency, or if any taxes or debts owing at any time
hereafter to any one or more of such entities becomes a lien, whether inchoate
or otherwise, upon any of Borrower's assets valued in the aggregate in excess of
$1,000,000 and the same is not paid on the payment date thereof;

          (k) If a judgment or other claim becomes a lien or encumbrance upon
any or all of Borrower's assets and the same is not satisfied, dismissed or
bonded against within thirty (30) days thereafter;

          (l) If Borrower's records (other than payroll) are prepared and kept
by an outside computer service bureau at the time this Agreement, the Note
and/or the Loan Documents are entered into or during the term of this Agreement,
the Note and/or the Loan Documents, such an agreement with an outside service
bureau is entered into, and at any time thereafter, without first obtaining the
written consent of Bank, Borrower terminates, modifies, amends or changes its
contractual relationship with said computer service bureau or said computer
service bureau fails to provide Bank with any requested information or financial
data pertaining to Bank's Collateral, Borrower's financial condition or the
results of Borrower's operations;

<PAGE>

          (m) If Borrower is in a default under any material agreement or
agreements to which Borrower is a party with third parties (other than Bank)
involving indebtedness to such third party or parties, in the aggregate in
excess of $500,000, whether under any indenture, agreement or otherwise;

          (n) If Borrower makes any payment on account of indebtedness which has
been subordinated to Borrower's obligations to Bank, including without
limitation the Indebtedness, unless such payment is permitted to be made
pursuant to the terms and conditions of the applicable subordination agreement;

          (o) If any material misrepresentation exists now or thereafter in any
warranty or representation made to Bank by any officer or director of Borrower,
or if any such warranty or representation is withdrawn by any officer or
director;

          (p) If any Guarantor of Borrower's obligations terminates or attempts
to terminate its guaranty, becomes insolvent or an insolvency proceeding is
commenced by or against any such Guarantor; or

          (q) If any reportable event, which the Bank determines constitutes
grounds for the termination of any deferred compensation plan (other than
Borrower's 401K plan) by the Pension Benefit Guaranty Corporation or for the
appointment by the appropriate United States District Court of a trustee to
administer any such plan, shall have occurred and be continuing thirty (30) days
after written notice of such determination shall have been given to Borrower by
Bank, or any such plan shall be terminated within the meaning of Title IV of the
Employment Retirement Income Security Act ("ERISA"), or a trustee shall be
appointed by the appropriate United States District Court to administer any such
plan, or the Pension Benefit Guaranty Corporation shall institute proceedings to
terminate any plan and in case of any event described in this Section 8, the
aggregate amount of the Borrower's liability to the Pension Benefit Guaranty
Corporation under Sections 4062, 4063 or 4064 of ERISA shall exceed five percent
(5%) of Borrower's Tangible Effective Net Worth.

          Bank shall not be obligated to make advances to Borrower during any
cure period provided for in Sections 8(f), 8(h), 8(k) and 8(q) above.

      9.  Rights and Remedies. The parties have agreed as follows with respect
to Bank's rights and remedies upon Default:

          (a) Bank shall have all rights and remedies available hereunder and
under the Note and the Loan Documents and under applicable law;

          (b) Bank may at its option without notice, accelerate the Indebtedness
and declare all Indebtedness to be due, owing and payable in full;

          (c) Bank may at its option without notice, cease advancing money or
extending credit to or for the benefit of Borrower under this Agreement or any
other agreement between Borrower and Bank.

<PAGE>

         (d) No Default (as defined in this Agreement, the Note and/or the Loan
Documents) shall be waived by Bank except in writing and a waiver of any Default
shall not be a waiver of any other default or of the same default on a future
occasion;

         (e) No single or partial exercise of any right, power or privilege
hereunder, or any delay in the exercise hereof, shall preclude other or further
exercise of the rights of the parties under this Agreement, the Note and/or the
Loan Documents; and

         (f) No forbearance on the part of Bank in enforcing any of its rights
under this Agreement, the Note and/or the Loan Documents nor any renewal,
extension or rearrangement of any payment or covenant to be made or performed by
Borrower hereunder shall constitute a waiver of any of the terms of this
Agreement, the Note, and/or the Loan Documents, or of any such right.

     10. Cross-Default. A Default under this Agreement shall also be a Default
under the Note and the Loan Documents, and vice versa. A Default under this
Agreement, the Note and/or the Loan Documents shall also be a Default under
every other note and other agreement between Bank and Borrower, and vice versa.

     11. Cross-Collateral. Any Collateral for this Agreement, the Note and/or
the Loan Documents shall also be Collateral for any other obligations owing by
Borrower to Bank. Notwithstanding the above, if the undersigned has given or
gives Bank a deed of trust or mortgage covering real property, that deed of
trust or mortgage shall not secure this Note or any other indebtedness of the
undersigned, unless expressly provided to the contrary in another place.

     12. Survival of Covenants, Agreements, Representations and Warranties. All
covenants, agreements, representations and warranties (a) previously made
(except as specifically subsequently modified); (b) made in connection herewith
or with the Note and/or the Loan Documents and/or any document contemplated
hereby; or (c) executed hereafter (unless such document expressly states that
this Agreement does not apply thereto) shall survive the borrowing hereunder and
thereunder and the repayment in full of the Note and/or the Loan Documents and
any amendments, renewals or extensions thereof and shall be deemed to have been
relied upon by Bank. All statements contained in any certificate or other
document delivered to Bank at any time by or on behalf of Borrower shall
constitute representations and warranties by Borrower.

     13. Miscellaneous. The parties agree to the following miscellaneous terms:

         (a) This Agreement, the Note and the Loan Documents shall be governed
by California law, without regard for the effect of conflict of laws;

         (b) Borrower agrees that it will pay all out of pocket costs of Bank
and expenses (including, without limitation, Bank's reasonable attorneys' fees
and costs and/or fees, transfer charges and costs of Bank's in-house counsel) in
connection with the preparation of this Agreement, the Note and/or the Loan
Documents and/or the documents contemplated hereby and the closing of the Loan;

<PAGE>

          (c) This Agreement, the Note and/or the Loan Documents shall inure to
the benefit of and shall be binding upon the parties hereto and their respective
successors and assigns; provided, however, that Borrower shall not assign or
transfer its right or obligations under this Agreement, the Note and/or the Loan
Documents without the prior written consent of Bank;

          (d) Borrower acknowledges that Bank may provide information regarding
Borrower and the Loan to Bank's parent, subsidiaries and affiliates and service
providers, subject to the terms of the Confidentiality Agreement; and

          (e) This Agreement is an integrated agreement and supersedes all prior
negotiations and agreements regarding the subject matter hereof. Any amendments
hereto shall be in writing and be signed by all parties hereto.

          (f) Certain initially capitalized terms used in this Agreement have
the meanings ascribed thereto in Addendum A to this Agreement.

     14. JURY WAIVER. THE BORROWER AND THE BANK ACKNOWLEDGE THAT THE RIGHT TO
TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY,
AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF
THEIR CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT, WAIVES
ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE
OR ENFORCEMENT OF, OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE INDEBTEDNESS.

                                      * * *

                [remainder of this page intentionally left blank]

                                      * * *

<PAGE>

     IN WITNESS WHEREOF, the parties have executed this Business Loan Agreement
as of the date first set forth above.

Address of Borrower:                          Borrower:

181 Technology Drive                          Interpore International, Inc.
Irvine, CA 92618

                                              By:_______________________________

                                              Name:_____________________________

                                              Title:____________________________

                                              By:_______________________________

                                              Name:_____________________________

                                              Title:____________________________

                                              Comerica Bank-California
                                              ("Bank")

                                              By:_______________________________
                                                       Dan McGregor
                                              Title:   Vice President

<PAGE>

                      ADDENDUM A TO BUSINESS LOAN AGREEMENT

     1. Definitions.

        Cash Flow as used in this Agreement means for any applicable period of
determination, the net income (as later defined) (after deduction for income
taxes and other taxes of Borrower or its subsidiaries, determined by reference
to income or profits of Borrower or its subsidiaries) for such period, plus, to
the extent deducted in computation of such net income, the amount of
depreciation and amortization expense and the amount of deferred tax liability
during such period, all as determined in accordance with GAAP.

        Cash Flow Coverage Ratio means the ratio, as of any applicable period of
determination, the numerator of which is net income plus depreciation plus
amortization plus (or minus) the increase (or decrease) in the deferred tax
liability minus dividends and S-Draws, if an S-Corp, at the greater of actual
draws or net income times the highest prevailing personal tax rate, and the
denominator of which is the current portion of long term debt plus the current
portion of capital lease payments for the same period of determination.

        Confidentiality Agreement means that certain letter agreement, dated
April 23, 2002, between Bank and Borrower, regarding Bank's agreement to keep
certain of Borrower's information confidential.

        Current Assets as used in this Agreement means, as of any applicable
date of determination, all unrestricted cash, CD's or marketable securities,
non-affiliated accounts receivable, United States Government securities and/or
claims against the United States Government, and inventories (held for sale in
the ordinary course of business) of Borrower and its subsidiaries.

        Current Liabilities as used in this Agreement means, as of any
applicable date of determination, (i) all liabilities of Borrower or its
subsidiaries that should be classified as current in accordance with GAAP,
including, without limitation, the outstanding principal of the Indebtedness
under this Agreement, the Note and/or the Loan Documents, plus (ii) to the
extent not otherwise included, all liabilities of Borrower to any of its
affiliates (including officers, directors, shareholders, subsidiaries and
commonly held companies), whether or not classified as current in accordance
with GAAP unless same shall be the long term portion of Subordinated Debt (as
defined below).

        Current Ratio as used in this Agreement means, as of an applicable date
of determination, Current Assets divided by Current Liabilities.

        Debt shall mean, as of any applicable date of determination, all items
of indebtedness, obligation or liability of a person, whether matured or
unmatured, liquidated or unliquidated, direct or indirect, absolute or
contingent, joint or several, that should be classified as liabilities in
accordance with GAAP excepting such liabilities as shall be Subordinated Debt
(as defined below).

        Fixed Charges as used in this Agreement means, as of any applicable
period of determination, with respect to Borrower and its subsidiaries, the sum,
without duplication, of

<PAGE>

(a) all interest paid or payable during such period by Borrower or its
subsidiaries on debt of such person; plus (b) all payments of principal or other
sums paid or payable during such period by such person with respect to Debt
having a final maturity more than one year from the date of creation of such
Debt; plus (c) all debt discount and expense amortized or required to be
amortized during such period by such person; plus (d) the maximum amount of all
rents and other payments paid or required to be paid by such person during such
period under any lease or other contract or arrangement providing for use of
real or personal property in respect of which such person is obligated as a
lessee, user or obligor; plus (e) all dividends and other distributions paid or
payable by Borrower (including S-Draws, if applicable, as per the Cash Flow
Coverage Ratio above) or its subsidiaries or otherwise accumulating during such
period on any capital stock of Borrower or its subsidiaries; plus (f) all loans
or other advances made by Borrower or its subsidiaries during such period to any
affiliate of such person.

          Guarantor means every person or entity who or which now or hereafter
executes a guaranty in favor of Bank with respect to the Indebtedness.

          Material Adverse Effect means a material adverse effect on (i) the
business, assets, condition (financial or otherwise), results of operations, or
prospects of Borrower and its subsidiaries taken as a whole, or any Guarantor;
(ii) the ability of Borrower to perform its obligations under this Agreement and
the Loan Documents to which it is a party (including, without limitation,
repayment of the Obligations as they come due), or the ability of any Guarantor
to perform its obligations under the Loan Documents to which it is a party,
(iii) the validity or enforceability of this Agreement, the Loan Documents, or
the rights or remedies of Bank hereunder and thereunder, (iv) the value of the
assets assigned or pledged to Bank as collateral, or (v) the priority of Bank's
liens with respect to the assets assigned or pledged thereto as collateral.

          Net Income shall mean the net income (or loss) of a person for any
period determined in accordance with GAAP but, however, excluding: (a) any gains
or losses on the sale or other disposition, not in the ordinary course of
business, of investments or fixed or capital assets, and any taxes on the
excluded gains and any tax deductions or credits on account on any excluded
losses; and (b) in the case of the Borrower, net earnings of any person in which
Borrower has an ownership interest, unless such net earnings shall have actually
been received by Borrower in the form of cash distributions.

          Permitted Indebtedness means (i) Indebtedness owing to Bank in
accordance with the terms of this Agreement and the Loan Documents, and (ii)
other indebtedness of Borrower up to a maximum aggregate amount of One Million
Dollars ($1,000,000) outstanding at any one time incurred in the ordinary course
of business and secured by the Liens described in clause (iv) of the definition
of Permitted Liens hereinbelow.

          Permitted Investments means any of the investments listed and
described on Addendum B attached hereto.

<PAGE>

          Permitted Liens means (i) Liens for current taxes, assessments or
other governmental charges which are not delinquent or remain payable without
any penalty, or are being contested in good faith by appropriate proceedings,
provided that, if delinquent, adequate reserves have been set aside with respect
thereto as required by GAAP and, by reason of nonpayment, no property is subject
to a material risk of loss or forfeiture; (ii) Liens in favor of Bank, in
accordance with the Loan Documents, (iii) statutory liens, such as inchoate
mechanics', inchoate materialmen's, landlord's, warehousemen's, and carriers'
liens, and other similar liens, other than those described in clause (i) above,
arising in the ordinary course of business with respect to obligations which are
not delinquent or are being contested in good faith by appropriate proceedings,
provided that, if delinquent, adequate reserves have been set aside with respect
thereto as required by GAAP and, by reason of nonpayment, no property is subject
to a material risk of loss or forfeiture; (iv) liens relating to indebtedness
owing under capital lease and purchase money obligations permitted hereunder (v)
judgment liens that do not constitute an Event of Default, and (vi) liens, if
they constitute such, of any true lease and consignment UCC filings permitted
hereunder.

          Quick Assets as used in this Agreement means, as of any applicable
date of determination, unrestricted cash, CD's or marketable securities and net
accounts receivable arising from the sale of goods and services, and United
States Government securities and/or claims against the United States Government
of Borrower and its subsidiaries.

          Quick Ratio as used in this Agreement means, as of an applicable date
of determination, Quick Assets divided by Current Liabilities, excluding
subordinated debt.

          Tangible Effective Net Worth as used in this Agreement means Tangible
Net Worth as of any applicable date of determination, increased by the long term
portion of Subordinated Debt (as defined below), if any, of Borrower or its
subsidiaries and decreased by the following: Subscription lists, organization
expenses, trade accounts receivable converted to notes, and money due to
Borrower or its subsidiaries from affiliates (including officers, directors,
subsidiaries and commonly held companies).

          Tangible Net Worth as used in this Agreement means, as of any
applicable date of determination, the excess of:

          (a) the net book value of all assets of Borrower and its subsidiaries
(other than patents, patent rights, trademarks, trade names, franchises,
copyrights, licenses, goodwill, and similar intangible assets) after all
appropriate deductions in accordance with GAAP (including, without limitation,
reserves for doubtful receivables, obsolescence, depreciation and amortization),
minus

          (b) all Total Liabilities of Borrower and its subsidiaries.

          Total Liabilities as used in this Agreement means, as of any
applicable date, the total of all items of indebtedness, obligation or liability
which, in accordance with GAAP consistently applied, would be included in
determining the total liabilities of Borrower or its subsidiaries, including,
without limitation, (a) all obligations secured by any mortgage, pledge,
security interest or other lien on property owned or acquired, whether or not
the obligations

<PAGE>

          secured thereby shall have been assumed; (b) all obligations which are
capitalized lease obligations; and (c) all guaranties, endorsements or other
contingent or surety obligations with respect to the indebtedness of others,
whether or not reflected on the balance sheets of Borrower or its subsidiaries,
including, without limitation, any obligation to furnish funds, directly or
indirectly through the purchase of goods, supplies, services, or by way of stock
purchase, capital contribution, advance or loan or any obligation to enter into
a contract for any of the foregoing.

          Total Liabilities to Tangible Effective Net Worth Ratio means, as of
any applicable date, Total Liabilities divided by Tangible Effective Net Worth.

          Subordinated Debt as used in this Agreement means indebtedness of
Borrower to third parties which has been subordinated to all Indebtedness owing
by Borrower to Bank pursuant to a subordination agreement in form and content
satisfactory to Bank.

          Working Capital as used in this Agreement means, as of any applicable
date of determination, Current Assets less Current Liabilities.

      2.  Financial Covenants. Borrower shall maintain the following financial
ratios and covenants on a consolidated basis, which shall be monitored on a
quarterly basis, except as noted below.

          (a) A ratio of Quick Assets to Current Liabilities of not less than
1.50:1.00;

          (b) A ratio of Total Liabilities (less Subordinated Debt as defined
herein) to Tangible Effective Net Worth of less than 0.70:1.00; and

          (c) Net Income on a quarterly basis of $1.00;

     All financial covenants shall be computed in accordance with GAAP
consistently applied except as otherwise specifically set forth in this
Agreement. All monies due from affiliates (including officers, directors and
shareholders) shall be excluded from Borrower's assets for all purposes
hereunder.

<PAGE>

[LOGO]

                              MASTER REVOLVING NOTE
                 Variable Rate-Maturity Date-Obligatory Advances
                      (Business and Commercial Loans Only)

--------------------------------------------------------------------------------
Amount             Note Date            Maturity Date      Tax Identification #
$10,000,000        June 14, 2002        June 14, 2005      95-3043318
--------------------------------------------------------------------------------

On the Maturity Date, as stated above, for value received, the undersigned
promise(s) to pay to the order of Comerica Bank-California ("Bank"), at any
office of the Bank in the State of California, Ten Million and no/100 Dollars
(U.S.) (or that portion of it advanced by the Bank and not repaid as later
provided) with interest until maturity, whether by acceleration or otherwise, or
an Event of Default, as later defined, at a per annum rate equal to the Bank's
base rate from time to time in effect minus 0.75% per annum and after that at a
rate equal to the rate of interest otherwise prevailing under this Note plus 3%
per annum (but in no event in excess of the maximum rate permitted by law). The
Bank's "base rate" is that annual rate of interest so designated by the Bank and
which is changed by the Bank from time to time. Interest rate changes will be
effective for interest computation purposes as and when the Bank's base rate
changes. Interest shall be calculated on the basis of a 360-day year for the
actual number of days the principal is outstanding. Accrued interest on this
Note shall be payable on the first day of each month commencing July 1, 2002,
until the Maturity Date when all amounts outstanding under this Note shall be
due and payable in full. If the frequency of interest payments is not otherwise
specified, accrued interest on this Note shall be payable monthly on the first
day of each month. If any payment of principal or interest under this Note shall
be payable on a day other than a day on which the Bank is open for business,
this payment shall be extended to the next succeeding business day and interest
shall be payable at the rate specified in this Note during this extension. A
late payment charge equal to 5% of each late payment may be charged on any
payment not received by the Bank within 10 calendar days after the payment due
date, but acceptance of payment of this charge shall not waive any Default under
this Note.

The principal amount payable under this Note shall be the sum of all advances
made by the Bank to or at the request of the undersigned, less principal
payments actually received in cash by the Bank. The books and records of the
Bank shall be the best evidence of the principal amount and the unpaid interest
amount owing at any time under this Note and shall be conclusive absent manifest
error. No interest shall accrue under this Note until the date of the first
advance made by the Bank; after that interest on all advances shall accrue and
be computed on the principal balance outstanding from time to time under this
Note until the same is paid in full.

This Note and any other indebtedness and liabilities of any kind of the
undersigned to the Bank, and any and all modifications, renewals or extensions
of it, whether joint or several, contingent or absolute, now existing or later
arising, and however evidenced (collectively "Indebtedness") are secured by and
the Bank is granted a security interest in all items deposited in any account of
any of the undersigned with the Bank and by all proceeds of these items (cash or
otherwise), all account balances of any of the undersigned from time to time
with the Bank, by all property of any of the undersigned from time to time in
the possession of the Bank and by any other

<PAGE>

collateral, rights and properties described in each and every deed of trust,
mortgage, security agreement, pledge, assignment and other security or
collateral agreement which has been, or will at any time(s) later be, executed
by any (or all) of the undersigned to or for the benefit of the Bank
(collectively "Collateral"). Notwithstanding the above, if the undersigned has
given or gives Bank a deed of trust or mortgage covering real property, that
deed of trust or mortgage shall not secure this Note or any other indebtedness
of the undersigned, unless expressly provided to the contrary in another place.

Upon the occurrence and during the continuance of an Event of Default (as
defined in that certain Business Loan Agreement, dated as of even date herewith,
between the undersigned and the Bank (the "Loan Agreement:"), the Bank may at
its option and without prior notice to the undersigned, declare any or all of
the Indebtedness to be immediately due and payable (notwithstanding any
provisions contained in the evidence of it to the contrary), cease advancing
money or extending credit to or for the benefit of the undersigned under this
Note or any other agreement between the undersigned and Bank, terminate this
Note as to any future liability or obligation of Bank, but without affecting
Bank's rights and security interests in any Collateral and the Indebtedness of
the undersigned to Bank, sell or liquidate all or any portion of the Collateral,
set off against the Indebtedness any amounts owing by the Bank to the
undersigned (or any of them), charge interest at the default rate provided in
the document evidencing the relevant Indebtedness and exercise any one or more
of the rights and remedies granted to the Bank by any agreement with the
undersigned or given to it under applicable law. In addition, if this Note is
secured by a deed of trust or mortgage covering real property, then the trustor
or mortgagor shall not mortgage or pledge the mortgaged premises as security for
any other indebtedness or obligations. This Note, together with all other
indebtedness secured by said deed of trust or mortgage, shall become due and
payable immediately, without notice, at the option of the Bank, (a) if said
trustor or mortgagor shall mortgage or pledge the mortgaged premises for any
other indebtedness or obligations or shall convey, assign or transfer the
mortgaged premises by deed, installment sale contract instrument, or (b) if the
title to the mortgaged premises shall become vested in any other person or party
in any manner whatsoever, or (c) if there is any disposition (through one or
more transactions) of legal or beneficial title to a controlling interest of
said trustor or mortgagor. All payments under this Note shall be in immediately
available United States funds, without setoff or counterclaim .

This Note shall bind the undersigned and the undersigned's successors and
assigns.

The undersigned waives presentment, demand, protest, notice of dishonor, notice
of demand or intent to demand, notice of acceleration or intent to accelerate,
and all other notices, and agrees that no extension or indulgence to the
undersigned or release, substitution or nonenforcement of any security, or
release or substitution of any of the undersigned, any guarantor or any other
party, whether with or without notice, shall affect the obligations of any of
the undersigned. The undersigned waives all defenses or right to discharge
available under Section 3605 of the California Uniform Commercial Code and
waives all other suretyship defenses or right to discharge. The undersigned
agrees that the Bank has the right to sell, assign, or grant participations, or
any interest, in any or all of the Indebtedness, and that, in connection with
this right, but without limiting its ability to make other disclosures to the
full extent allowable, the Bank may disclose all documents and information which
the Bank now or later has relating to the undersigned or the Indebtedness. The
undersigned agrees that the Bank may provide

<PAGE>

information relating to the Note or to the undersigned to the Bank's parent,
affiliates, subsidiaries and service providers, subject to the terms of the
Confidentiality Agreement (as defined in the Loan Agreement).

The undersigned agrees to reimburse the holder or owner of this Note for any and
all costs and expenses (including without limit, court costs, legal expenses and
reasonable attorney fees, whether inside or outside counsel is used, whether or
not suit is instituted and, if suit is instituted, whether at the trial court
level, appellate level, in a bankruptcy, probate or administrative proceeding or
otherwise) incurred in collecting or attempting to collect this Note or incurred
in any other matter or proceeding relating to this Note.

The undersigned acknowledges and agrees that there are no contrary agreements,
oral or written, establishing a term of this Note and agrees that the terms and
conditions of this Note may not be amended, waived or modified except in a
writing signed by an officer of the Bank expressly stating that the writing
constitutes an amendment, waiver or modification of the terms of this Note. As
used in this Note, the word "undersigned" means, individually and collectively,
each maker, accommodation party, indorser and other party signing this Note in a
similar capacity. If any provision of this Note is unenforceable in whole or
part for any reason, the remaining provisions shall continue to be effective.
THIS NOTE IS MADE IN THE STATE OF CALIFORNIA AND SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF CALIFORNIA,
WITHOUT REGARD TO CONFLICT OF LAWS PRINCIPLES.

THE UNDERSIGNED AND THE BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED, EACH PARTY, AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR CHOICE, KNOWINGLY
AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT, WAIVES ANY RIGHT TO TRIAL BY JURY
IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE OR ENFORCEMENT OF, OR IN
ANY WAY RELATED TO, THIS NOTE OR THE INDEBTEDNESS.

See Libor Addendum for rate option.

See Loan Agreement and any modifications,
replacements, or substitutions therefore.

INITIAL HERE ______

Interpore International, Inc.

By:___________________________________________its_____________________________
SIGNATURE OF                                TITLE:

By:___________________________________________its_____________________________

<PAGE>

SIGNATURE OF                                         TITLE:

181 Technology Drive        Irvine          CA          USA          92618
-----------------------------------------------------------------------------
Street Address              City            State       Country      Zip Code

<TABLE>
<CAPTION>
                             For Bank Use Only                            CCAR#
------------------------------------------------------------------------------------------------------
<S>                          <C>                     <C>                  <C>       <C>        <C>
Loan Officer Initials        Loan Group name         Obligor(s) Name

------------------------------------------------------------------------------------------------------
Loan Officer I.D. No.        Loan Group No.          Obligor #                      Note #     Amount

------------------------------------------------------------------------------------------------------
</TABLE>

<PAGE>

                                      LIBOR
                        Addendum To Master Revolving Note

     This Addendum to Master Revolving Note (this "Addendum") is entered into as
of this 14th day of June, 2002, by and between Comerica Bank-California ("Bank")
and Interpore International, Inc. ("Borrower"). This Addendum supplements the
terms of the Master Revolving Note of even date herewith.

15.  Definitions.

     (a) Advance. As used herein, "Advance" means a borrowing requested by
Borrower and made by Bank under the Note, including a LIBOR Option Advance
and/or a Base Rate Option Advance.

     (b) Business Day. As used herein, "Business Day" means any day except a
Saturday, Sunday or any other day designated as a holiday under Federal or
California statute or regulation.

     (c) LIBOR. As used herein, "LIBOR" means the rate per annum (rounded upward
if necessary, to the nearest whole 1/8 of 1%) and determined pursuant to the
following formula:

         LIBOR=             Base LIBOR
                  100% - LIBOR Reserve Percentage

         (1) "Base LIBOR" means the rate per annum determined by Bank at which
             deposits for the relevant LIBOR Period would be offered to Bank in
             the approximate amount of the relevant LIBOR Option Advance in the
             inter-bank LIBOR market selected by Bank, upon request of Bank at
             10:00 a.m. California time, on the day that is the first day of
             such LIBOR Period.

         (2) "LIBOR Reserve Percentage" means the reserve percentage rescribed
             by the Board of Governors of the Federal Reserve System (or any
             successor) for "Eurocurrency Liabilities" (as defined in Regulation
             D of the Federal Reserve Board, as amended), adjusted by Bank for
             expected changes in such reserve percentage during the applicable
             LIBOR Period.

     (d) LIBOR Business Day. As used herein, "LIBOR Business Day" means a
Business day on which dealings in Dollar deposits may be carried out in the
interbank LIBOR market.

     (e) LIBOR Period. As used herein, "LIBOR Period" means, with respect to a
LIBOR Option Advance:

         (1) initially, the period commencing on, as the case may be, the date
             the Advance is made or the date on which the Advance is converted
             to a LIBOR Option Advance, and continuing for, in every case, a
             thirty (30), sixty (60) or ninety (90) day period, thereafter so
             long as the LIBOR Option is quoted for such period in the
             applicable interbank LIBOR market, as such period is selected by
             Borrower in the notice of Advance as

<PAGE>

                   provided in the Note or in the notice of conversion as
                   provided in this Addendum; and

            (2)    thereafter, each period commencing on the last day of the
                   next preceding LIBOR Period applicable to such LIBOR Option
                   Advance and continuing for, in every case, on a thirty (30),
                   sixty (60) or ninety (90) day period, thereafter so long as
                   the LIBOR Option is quoted for such period in the applicable
                   interbank LIBOR market, as such period is selected by
                   Borrower in the notice of continuation as provided in this
                   Addendum.

      (f)   Note. As used herein, "Note" means the Master Revolving Note of even
date herewith.

      (g)   Regulation D. As used herein, "Regulation D" means Regulation D of
the Board of Governors of the Federal Reserve System as amended or supplemented
from time to time.

      (h)   Regulatory Development. As used herein, "Regulatory Development"
means any or all of the following: (i) any change in any law, regulation or
interpretation thereof by any public authority (whether or not having the force
of law); (ii) the application of any existing law, regulation or the
interpretation thereof by any public authority (whether or not having the force
of law); and (iii) compliance by Bank with any request or directive (whether or
not having the force of law) of any public authority.

16.   Interest Rate Options. Borrower shall have the following options regarding
the interest rate to be paid by Borrower on Advances under the Note:

      (a)   A rate equal to one and three quarter percent (1.75%) above Bank's
            LIBOR, (the "LIBOR Option"), which LIBOR Option shall be in effect
            during the relevant LIBOR Period; or

      (b)   A rate equal to three quarters of one percent (0.75%) below the
            "Base Rate" as referenced in the Note and quoted from time to time
            by Bank as such rate may change from time to time (the "Base Rate
            Option").

17.   LIBOR Option Advance. The minimum LIBOR Option Advance will not be less
than Five Hundred Thousand and 00/100 Dollars ($500,000.00) for any LIBOR Option
Advance.

18.   Payment of Interest on LIBOR Option Advances. Interest on each LIBOR
Option Advance shall be payable pursuant to the terms of the Note. Interest on
such LIBOR Option Advance shall be computed on the basis of a 360-day year and
shall be assessed for the actual number of days elapsed from the first day of
the LIBOR Period applicable thereto but not including the last day thereof.

19.   Bank's Records Re: LIBOR Option Advances. With respect to each LIBOR
Option Advance, Bank is hereby authorized to note the date, principal amount,
interest rate and LIBOR Period applicable thereto and any payments made thereon
on Bank's books and records (either manually or by electronic entry) and/or on
any schedule attached to the Note, which notations shall be prima facie evidence
of the accuracy of the information noted.

<PAGE>

20.   Selection/Conversion of Interest Rate Options. At the time any Advance is
requested under the Note and/or Borrower wishes to select the LIBOR Option for
all or a portion of the outstanding principal balance of the Note, and at the
end of each LIBOR Period, Borrower shall give Bank notice specifying (a) the
interest rate option selected by Borrower; (b) the principal amount subject
thereto; and (c) if the LIBOR Option is selected, the length of the applicable
LIBOR Period. Any such notice may be given by telephone so long as, with respect
to each LIBOR Option selected by Borrower, (i) Bank receives written
confirmation from Borrower not later than three (3) LIBOR Business Days after
such telephone notice is given; and (ii) such notice is given to Bank prior to
10:00 a.m., California time, on the first day of the LIBOR Period. For each
LIBOR Option requested hereunder, Bank will quote the applicable fixed LIBOR
Rate to Borrower at approximately 10:00 a.m., California time, on the first day
of the LIBOR Period. If Borrower does not immediately accept the rate quoted by
Bank, any subsequent acceptance by Borrower shall be subject to a
redetermination of the rate by Bank; provided, however, that if Borrower fails
to accept any such quotation given, then the quoted rate shall expire and Bank
shall have no obligation to permit a LIBOR Option to be selected on such day. If
no specific designation of interest is made at the time any Advance is requested
under the Note or at the end of any LIBOR Period, Borrower shall be deemed to
have selected the Base Rate Option for such Advance or the principal amount to
which such LIBOR Period applied. At any time the LIBOR Option is in effect,
Borrower may, at the end of the applicable LIBOR Period, convert to the Base
Rate Option. At any time the Base Rate Option is in effect, Borrower may convert
to the LIBOR OPTION, and shall designate a LIBOR Period.

21.   Default Interest Rate. From and after the maturity date of the Note, or
such earlier date as all principal owing hereunder becomes due and payable by
acceleration or otherwise, the outstanding principal balance of the Note shall
bear interest until paid in full at an increased rate per annum (computed on the
basis of a 360-day year, actual days elapsed) equal to three percent (3.00%)
above the rate of interest from time to time applicable to the Note.

22.   Prepayment. Bank is not under any obligation to accept any prepayment of
any LIBOR Option Advance except as described below or as required under
applicable law. Borrower may prepay a Base Rate Option Advance at any time,
without paying any Prepayment Amount, as defined below. Borrower may prepay an
LIBOR Option Advance in increments of Five Hundred Dollars ($500.00) prior to
the end of the LIBOR Period, as long as (i) Bank is provided written notice of
such prepayment at least five (5) LIBOR Business Days prior to the date thereof
(the "Prepayment Date"); and (ii) Borrower pays the Prepayment Amount. The
notice of prepayment shall contain the following information: (a) the Prepayment
Date; and (b) the LIBOR Option Advance which will be prepaid. On the Prepayment
Date, Borrower shall pay to Bank, in addition to any other amount that may then
be due on the Note, the Prepayment Amount. Bank, in its sole discretion, may
accept any prepayment of a LIBOR Option Advance even if not required to do so
under the Note and may deduct from the amount to be applied against the LIBOR
Option Advance any other amounts required to be paid as part of the Prepayment
Amount.

      The Prepaid Principal Amount (as defined below) will be applied to the
LIBOR Option Advance being prepaid as Bank shall determine in its sole
discretion.

<PAGE>

      If Bank exercises its right to accelerate the payment of the Note prior to
maturity based upon an Event of Default under the Note, Borrower shall pay to
Bank, in addition to any other amounts that may then be due on the Note, on the
date specified by Bank as the Prepayment Date, the Prepayment Amount.

      Bank's determination of the Prepayment Amount shall be conclusive in the
absence of obvious error or fraud. If requested in writing by Borrower, Bank
shall provide Borrower a written statement specifying the Prepayment Amount.

      The following (the "Prepayment Amount") shall be due and payable in full
on the Prepayment Date:

      (a)   If the principal amount of the LIBOR Option Advance being prepaid
exceeds Seven Hundred Fifty Thousand Dollars ($750,000), then the Prepayment
Amount is the sum of: (i) the amount of the principal balance of the LIBOR
Option Advance which Borrower has elected to prepay or the amount of the
principal balance of the LIBOR Option Advance which Bank has required Borrower
to prepay because of acceleration, as the case may be (the "Prepaid Principal
Amount"); (ii) interest accruing on the Prepaid Principal Amount up to, but not
including, the Prepayment Date; (iii) Five Hundred Dollars ($500.00); plus (iv)
the present value, discounted at the Reinvestment Rates (as defined below) of
the positive amount by which (A) the interest Bank would have earned had the
Prepaid Principal Amount not been paid prior to the end of the LIBOR Period at
the Note's interest rate exceeds (B) the interest Bank would earn by reinvesting
the Prepaid Principal Amount at the Reinvestment Rates.

      (b)   If the principal amount of the LIBOR Option Advance being prepaid is
Seven Hundred Fifty Thousand Dollars ($750,000) or less, then the Prepayment
Amount is the sum of: (i) the principal amount of the LIBOR Option Advance which
Borrower has elected to prepay or the principal amount of the LIBOR Option
Advance which Bank has required Borrower to prepay because of acceleration due
to an Event of Default under the Note, as the case may be (the "Prepaid
Principal Amount"); (ii) interest accruing on the Prepaid Principal Amount up
to, but not including, the Prepayment Date; plus (iii) an amount equal to two
percent (2%) of the Prepaid Principal Amount.

      "Reinvestment Rates" mean the per annum rates of interest equal to one
half percent (1/2%) above the rates of interest reasonably determined by Bank to
be in effect not more than seven (7) days prior to the Prepayment Date in the
secondary market for United States Treasury Obligations in amount(s) and with
maturity(ies) which correspond (as closely as possible) to the LIBOR Option
Advance being prepaid.

      BY INITIALING BELOW, BORROWER ACKNOWLEDGE(S) AND AGREE(S) THAT: (A) THERE
IS NO RIGHT TO PREPAY ANY LIBOR OPTION ADVANCE, IN WHOLE OR IN PART, WITHOUT
PAYING THE PREPAYMENT AMOUNT, EXCEPT AS OTHERWISE REQUIRED UNDER APPLICABLE LAW;
(B) BORROWER SHALL BE LIABLE FOR PAYMENT OF THE PREPAYMENT AMOUNT IF BANK
EXERCISES ITS RIGHT TO ACCELERATE PAYMENT OF ANY LIBOR OPTION ADVANCE AS PART OR
ALL OF THE OBLIGATIONS OWING UNDER THE NOTE, INCLUDING WITHOUT LIMITATION,
ACCELERATION UNDER A DUE-ON-SALE PROVISION; (C) BORROWER

<PAGE>

WAIVES ANY RIGHTS UNDER SECTION 2954.10 OF THE CALIFORNIA CIVIL CODE, OR ANY
SUCCESSOR STATUTE; AND (D) BANK HAS MADE EACH LIBOR OPTION ADVANCE PURSUANT TO
THE NOTE IN RELIANCE ON THESE AGREEMENTS.

_______________________
BORROWER'S INITIALS

23.   Hold Harmless and Indemnification. Borrower agrees to indemnify Bank and
to hold Bank harmless from, and to reimburse Bank on demand for, all losses and
expenses which Bank sustains or incurs as a result of (i) any payment of a LIBOR
Option Advance prior to the last day of the applicable LIBOR Period for any
reason, including, without limitation, termination of the Note, whether pursuant
to this Addendum or the occurrence of an Event of Default; (ii) any termination
of a LIBOR Period prior to the date it would otherwise end in accordance with
this Addendum; or (iii) any failure by Borrower, for any reason, to borrow any
portion of a LIBOR Option Advance.

24.   Funding Losses. The indemnification and hold harmless provisions set forth
in this Addendum shall include, without limitation, all losses and expenses
arising from interest and fees that Bank pays to lenders of funds it obtains in
order to fund the loans to Borrower on the basis of the LIBOR Option(s) and all
losses incurred in liquidating or re-deploying deposits from which such funds
were obtained and loss of profit for the period after termination. A written
statement by Bank to Borrower of such losses and expenses shall be conclusive
and binding, absent manifest error, for all purposes. This obligation shall
survive the termination of this Addendum and the payment of the Note.

25.   Regulatory Developments Or Other Circumstances Relating To Illegality or
Impracticality of LIBOR. If any Regulatory Development or other circumstances
relating to the interbank Euro-dollar markets shall, at any time, in Bank's
reasonable determination , make it unlawful or impractical for Bank to fund or
maintain, during any LIBOR Period, to determine or charge interest rates based
upon LIBOR, Bank shall give notice of such circumstances to Borrower and:

      A.    In the case of a LIBOR Period in progress, Borrower shall, if
requested by Bank, promptly pay any interest which had accrued prior to such
request and the date of such request shall be deemed to be the last day of the
term of the LIBOR Period; and

      B.    No LIBOR Period may be designated thereafter until Bank determines
that such would be practical.

26.   Additional Costs. Borrower shall pay to Bank from time to time, upon
Bank's request, such amounts as Bank determines are needed to compensate Bank
for any costs it incurred which are attributable to Bank having made or
maintained a LIBOR Option Advance or to Bank's obligation to make a LIBOR Option
Advance, or any reduction in any amount receivable by Bank hereunder with
respect to any LIBOR Option or such obligation (such increases in costs and
reductions in amounts receivable being herein called "Additional Costs"),
resulting from any Regulatory Developments, which (i) change the basis of
taxation of any amounts payable to Bank hereunder with respect to taxation of
any amounts payable to Bank hereunder with respect to any LIBOR Option Advance
(other than taxes imposed on the overall net income of Bank for any LIBOR Option
Advance by the jurisdiction where Bank is headquartered or the jurisdiction

<PAGE>

where Bank extends the LIBOR Option Advance; (ii) impose or modify any reserve,
special deposit, or similar requirements relating to any extensions of credit or
other assets of, or any deposits with or other liabilities of, Bank (including
any LIBOR Option Advance or any deposits referred to in the definition of
LIBOR); or (iii) impose any other condition affecting this Addendum (or any of
such extension of credit or liabilities). Bank shall notify Borrower of any
event occurring after the date hereof which entitles Bank to compensation
pursuant to this paragraph as promptly as practicable after it obtains knowledge
thereof and determines to request such compensation. Determinations by Bank for
purposes of this paragraph, shall be conclusive, provided that such
determinations are made on a reasonable basis.

27.   Legal Effect. Except as specifically modified hereby, all of the terms and
conditions of the Note remain in full force and effect.

      IN WITNESS WHEREOF, the parties have agreed to the foregoing as of the
date first set forth above.

INTERPORE INTERNATIONAL, INC.                     COMERICA BANK-CALIFORNIA

By:___________________________                    By:__________________________
                                                           Dan McGregor
Title:________________________                    Title: Vice President

By:___________________________

Title:________________________

<PAGE>

[LOGO]

          Security Agreement

As of June 14, 2002, for value received, the undersigned ("Debtor") pledges,
assigns and grants to Comerica Bank-California ("Bank"), a California banking
corporation, whose address is 333 West Santa Clara Street, San Jose, CA 95113,
Attention: Commercial Loan Documentation, Mail Code 4770, a continuing security
interest and lien (any pledge, assignment, security interest or other lien
arising hereunder is sometimes referred to herein as a "security interest") in
all of Debtor's right, title and interest in and to the collateral (as defined
below) to secure payment when due, whether by stated maturity, demand
acceleration or otherwise, of all existing and future indebtedness
("Indebtedness") to the Bank of Debtor. Indebtedness includes without limit any
and all obligations or liabilities of the Debtor to the Bank, whether absolute
or contingent, direct or indirect, voluntary or involuntary, liquidated or
unliquidated, joint or several, known or unknown; any and all obligations or
liabilities for which the Debtor would otherwise be liable to the Bank were it
not for the invalidity or unenforceability of them by reason of any bankruptcy,
insolvency or other law, or for any other reason; any and all amendments,
modifications, renewals and/or extensions of any of the above; all costs
incurred by Bank in establishing, determining, continuing, or defending the
validity or priority of its security interest, or in pursuing its rights and
remedies under this Agreement or under any other agreement between Bank and
Debtor or in connection with any proceeding involving Bank as a result of any
financial accommodation to Debtor; and all other costs of collecting
Indebtedness, including without limit attorney fees. Debtor agrees to pay Bank
all such costs incurred by the Bank, immediately upon demand, and until paid all
costs shall bear interest at the highest per annum rate applicable to any of the
Indebtedness, but not in excess of the maximum rate permitted by law. Any
reference in this Agreement to attorney fees shall be deemed a reference to
reasonable fees, costs, and expenses of both in-house and outside counsel and
paralegals, whether inside or outside counsel is used, whether or not a suit or
action is instituted, and to court costs if a suit or action is instituted, and
whether attorney fees or court costs are incurred at the trial court level, on
appeal, in a bankruptcy, administrative or probate proceeding or otherwise.
Debtor further covenants, agrees and represents as follows:

Collateral shall mean all of the following property Debtor now or later owns or
has an interest in, wherever located:

X  all Accounts Receivable (for purposes of this Agreement, "Accounts
   Receivable" consists of all accounts, general intangibles, chattel paper
   (including without limit electronic chattel paper and tangible chattel
   paper),contract rights, deposit accounts, documents, instruments and rights
   to payment evidenced by chattel paper, documents or instruments health care
   insurance receivables, commercial tort claims, letters of credit, letter of
   credit rights, supporting obligations, and rights to payment for money or
   funds advanced or sold),

X  all Inventory,

X  all Equipment and Fixtures,

<PAGE>

X  all Software (for purposes of this Agreement "Software" consists of all (i)
   computer programs and supporting information provided in connection with a
   transaction relating to the program, and (ii) computer programs embedded in
   goods and any supporting information provided in connection with a
   transaction relating to the program whether or not the program is associated
   with the goods in such a manner that it customarily is considered part of the
   goods, and whether or not, by becoming the owner of the goods, a person
   acquires a right to use the program in connection with the goods, and whether
   or not the program is embedded in goods that consist solely of the medium in
   which the program is embedded),

X  specific items listed below and/or on attached Schedule A, if any, is/are
   also included in Collateral:

X  all goods, instruments, documents, policies and certificates of insurance,
   deposits, money or other property (except real property which is not a
   fixture) which are now or later in possession of Bank, or as to which Bank
   now or later controls possession by documents or otherwise, and

X  all additions, attachments, accessions, parts, replacements, substitutions,
   renewals, interest, dividends distributions, rights of any kind (including
   but not limited to stock splits, stock rights, voting and preferential
   rights), products, and proceeds of or pertaining to the above including,
   without limit, cash or other property which were proceeds and are recovered
   by a bankruptcy trustee or otherwise as a preferential transfer by Debtor.

In the definition of Collateral, a reference to a type of collateral shall not
be limited by a separate reference more specific or narrower type of that
collateral.

Warranties, Covenants and Agreements. Debtor warrants, covenants and agrees as
follows:

         Debtor shall furnish to Bank, in form and at intervals as Bank may
                request, any information Bank may reasonably request and allow
                Bank to examine, inspect, and copy any of Debtor's books and
                records (upon three (3) business days' notice unless an Event of
                Default has occurred and is continuing, in which event no notice
                shall be required), subject to the terms of the Confidentiality
                Agreement. Debtor shall, at the reasonable request of Bank, mark
                its records pertaining to the Collateral to clearly indicate the
                security interest of Bank under this Agreement.

         At the time any Collateral becomes, or is represented to be, subject to
                a security interest in favor of Bank Debtor shall be deemed to
                have warranted that (a) Debtor is the lawful owner of the
                Collateral and has the right and authority to subject it to a
                security interest granted to Bank; (b) none of the Collateral is
                subject to any security interest other than Permitted Liens; (c)
                there are no financing statements on file, other than in favor
                of Bank or in connection with Permitted Liens; (d) no person,
                other than Bank, has possession or control (as defined in the
                Uniform Commercial Code) of any Collateral of such nature that
                perfection of a security interest may be accomplished by
                control; and (e) Debtor acquired its rights in the Collateral in
                the ordinary course of its business.

<PAGE>

         Debtor will keep the Collateral free at all times from all claims,
                liens, security interests and encumbrances other than Permitted
                Liens. Debtor will not, without the prior written consent of
                Bank, sell, transfer or lease, or permit to be sold, transferred
                or leased, any or all of the Collateral, except as permitted
                under the terms of the Loan Agreement (as hereinafter defined),
                and will not return any Inventory to its supplier. Bank or its
                representatives may at all reasonable times inspect the
                Collateral and may enter upon all premises where the Collateral
                is kept or might be located (upon three (3) business days'
                notice unless an Event of Default has occurred and is
                continuing, in which event no notice shall be required).

         Debtor will do all acts and will execute or cause to be executed all
                writings reasonably requested by Bank to establish, maintain and
                continue an exclusive, perfected and first security interest of
                Bank in the Collateral. Debtor agrees that Bank has no
                obligation to acquire or perfect any lien on or security
                interest in any asset(s), whether realty or personalty, to
                secure payment of the Indebtedness, and Debtor is not relying
                upon assets in which the Bank may have a lien or security
                interest for payment of the indebtedness.

         Debtor will pay within the time that they can be paid without
                interest or penalty all taxes, assessments and similar charges
                which at any time are or may become a lien, charge, or
                encumbrance upon any Collateral, except to the extent Borrower
                is contesting the same in good faith in appropriate proceedings
                and Borrower has established reserves in accordance with GAAP.
                If Debtor fails to pay any of these taxes, assessments, or other
                charges in the time provided above, Bank has the option (but not
                the obligation) to do so and Debtor agrees to repay all amounts
                so expended by Bank immediately upon demand, together with
                interest at the highest lawful default rate which could be
                charged by Bank on any Indebtedness.

         Debtor will keep the Collateral in good condition and will protect it
                from loss, damage, or deterioration from any cause. Debtor has
                and will maintain at all times (a) with respect to the
                Collateral, insurance under an "all risk" policy against fire
                and other risks customarily insured against, and (b) public
                liability insurance and other insurance as may be required by
                law or reasonably required by Bank, all of which insurance shall
                be in amount, form and content, and written by companies as may
                be satisfactory to Bank, containing a lender's loss payable
                endorsement acceptable to Bank. Debtor will deliver to Bank
                immediately upon demand evidence satisfactory to Bank that the
                required insurance has been procured. If Debtor fails to
                maintain satisfactory insurance Bank has the option (but not the
                obligation) to do so and Debtor agrees to repay all amounts so
                expended by Bank immediately upon demand, together with interest
                at the highest lawful default rate which could be charged by
                Bank on any Indebtedness.

         [Intentionally Omitted.]

         Debtor at all times shall be in strict compliance with all
                Environmental Laws.

<PAGE>

             If Bank, acting in its sole discretion, redelivers Collateral to
                Debtor or Debtor's designee for the purpose of (a) the ultimate
                sale or exchange thereof; or (b) presentation, collection,
                renewal, or registration of transfer thereof; or (c) loading,
                unloading, storing, shipping, transshipping, manufacturing,
                processing or otherwise dealing with it preliminary to sale or
                exchange; such redelivery shall be in trust for the benefit of
                Bank and shall not constitute a release of Bank's security
                interest in it or in the proceeds or products of it unless Bank
                specifically so agrees in writing. If Debtor requests any such
                redelivery, Debtor will deliver with such request a duty
                executed financing statement in form and substance satisfactory
                to Bank. Any proceeds of Collateral coming into Debtor's
                possession as a result of any such redelivery shall be held in
                trust for Bank and immediately delivered to Bank for application
                on the Indebtedness. Bank may (in its sole discretion) deliver
                any or all of the Collateral to Debtor, and such delivery by
                Bank shall discharge Bank from all liability or responsibility
                for such Collateral. Bank, at its option, may require delivery
                of any Collateral to Bank at any time with such endorsements or
                assignments of the Collateral as Bank may request.

             At any time and without notice, upon the occurrence and during
                the continuance of an Event of Default, Bank may, as to
                Collateral other than Equipment, Fixtures or Inventory, (a)
                cause any or all of such Collateral to be transferred to its
                name or to the name of its nominees; (b) receive or collect by
                legal proceedings or otherwise all dividends, interest,
                principal payments and other sums and all other distributions at
                any time payable or receivable on account of such Collateral,
                and hold the same as Collateral or apply the same to the
                Indebtedness, the manner and distribution of the application to
                be in the sole discretion of Bank; (c) enter into any extension,
                subordination, reorganization, deposit, merger or consolidation
                agreement or any other agreement relating to or affecting such
                Collateral, and deposit or surrender control of such Collateral,
                and accept other property in exchange for such Collateral and
                hold or apply the property or money so received pursuant to this
                Agreement; and (d) take such actions in its own name or in
                Debtor's name as Bank, in its sole discretion, deems necessary
                or appropriate to establish exclusive control (as defined in the
                Uniform Commercial Code) over any Collateral of such nature that
                perfection of the Bank's security interest may be accomplished
                by control.

             Bank may assign any of the Indebtedness and deliver any or all of
                the Collateral to its assignee, who then shall have with respect
                to Collateral so delivered all the rights and powers of Bank
                under this Agreement, and after that Bank shall be fully
                discharged from all liability and responsibility with respect to
                Collateral so delivered.

             [Intentionally Omitted.]

             Debtor shall defend, indemnify and hold harmless Bank, its
                employees, agents, shareholders, affiliates, officers, and
                directors from and against any and all claims, damages, fines,
                expenses, liabilities or causes of action of whatever kind,
                including without limit consultant fees, legal expenses, and
                attorney fees, suffered

<PAGE>

                by any of them as a direct or indirect result of any actual or
                asserted violation of any law, including, without limit,
                Environmental Laws, or of any remediation relating to any
                property required by any law, including without limit
                Environmental Laws, INCLUDING ANY CLAIMS, DAMAGES, FINES,
                EXPENSES, LIABILITIES OR CAUSES OF ACTION OF WHATEVER KIND
                RESULTING FROM BANK'S OWN NEGLIGENCE, except and to the extent
                (but only to the extent) caused by Bank's gross negligence or
                willful misconduct.

Collection of Proceeds.

         Debtor agrees to collect and enforce payment of all Collateral until
                Bank shall direct Debtor to the contrary. Immediately upon
                notice to Debtor by Bank and at all times after that, after the
                occurrence and during the continuance of an Event of Default
                Debtor agrees to fully and promptly cooperate and assist Bank in
                the collection and enforcement of all Collateral and to hold in
                trust for Bank all payments received in connection with
                Collateral and from the sale, lease or other disposition of any
                Collateral, all rights by way of suretyship or guaranty and all
                rights in the nature of a lien or security interest which Debtor
                now or later has regarding Collateral. Immediately upon and
                after such notice, Debtor agrees to (a) endorse to Bank and
                immediately deliver to Bank all payments received on Collateral
                or from the sale, lease or other disposition of any Collateral
                or arising from any other rights or interests of Debtor in the
                Collateral, in the form received by Debtor without commingling
                with any other funds, and (b) immediately deliver to Bank all
                property in Debtor's possession or later coming into Debtor's
                possession through enforcement of Debtor's rights or interests
                in the Collateral. Debtor irrevocably authorizes Bank or any
                Bank employee or agent to endorse the name of Debtor upon any
                checks or other items which are received in payment for any
                Collateral, and to do any and all things necessary in order to
                reduce these items to money. Bank shall have no duty as to the
                collection or protection of Collateral or the proceeds of it,
                nor as to the preservation of any related rights, beyond the use
                of reasonable care in the custody and preservation of Collateral
                in the possession of Bank. Debtor agrees to take all steps
                necessary to preserve rights against prior parties with respect
                to the Collateral. Nothing in this Section 3.1 shall be deemed a
                consent by Bank to any sale, lease or other disposition of any
                Collateral.

         Debtor agrees that immediately upon Bank's request (upon the occurrence
                and during the continuance of an Event of Default) the
                indebtedness shall be on a "remittance basis" as follows: Debtor
                shall at its sole expense establish and maintain (and Bank at
                Bank's option, may establish and maintain at Debtor's expense):
                (a) an United States Post Office lock box (the "Lock Box"), to
                which Bank shall have exclusive access and control. Debtor
                expressly authorizes Bank, from time to time, to remove contents
                from the Lock Box, for disposition in accordance with this
                Agreement. Debtor agrees to notify all account debtors and other
                parties obligated to Debtor that all payments made to Debtor
                (other than payments by electronic funds transfer) shall be
                remitted, for the credit of Debtor, to the Lock Box, and Debtor
                shall include a like statement on all invoices; and (b) a non-

<PAGE>

                  interest bearing deposit account with Bank which shall be
                  titled as designated by Bank (the "Cash Collateral Account")
                  to which Bank shall have exclusive access and control. Debtor
                  agrees to notify all account debtors and other parties
                  obligated to Debtor that all payments made to Debtor by
                  electronic funds transfer shall be remitted to the Cash
                  Collateral Account, and Debtor, at Bank's request, shall
                  include a like statement on all invoices. Debtor shall execute
                  all documents and authorizations as required by Bank to
                  establish and maintain the Lock Box and the Cash Collateral
                  Account.

              All items or amounts which are remitted to the Lock Box, to the
                  Cash Collateral Account, or otherwise delivered by or for the
                  benefit of Debtor to Bank on account of partial or full
                  payment of, or with respect to, any Collateral shalt, at
                  Bank's option, (a) be applied to the payment of the
                  Indebtedness, whether then due or not, in such order or at
                  such time of application as Bank may determine in its sole
                  discretion, or, (b) be deposited to the Cash Collateral
                  Account. Debtor agrees that Bank shall not be liable for any
                  loss or damage which Debtor may suffer as a result of Bank's
                  processing of items or its exercise of any other rights or
                  remedies under this Agreement, including without limitation
                  indirect, special or consequential damages, loss of revenues
                  or profits, or any claim, demand or action by any third party
                  arising out of or in connection with the processing of items
                  or the exercise of any other rights or remedies under this
                  Agreement. Debtor agrees to indemnify and hold Bank harmless
                  from and against all such third party claims, demands or
                  actions, and all related expenses or liabilities, including,
                  without limitation, attorney's fees and INCLUDING CLAIMS,
                  DAMAGES, FINES, EXPENSES, LIABILITIES OR CAUSES OF ACTION OF
                  WHATEVER KIND RESULTING FROM BANK'S OWN NEGLIGENCE except to
                  the extent (but only to the extent) caused by Bank's gross
                  negligence or willful misconduct.

Defaults, Enforcement and Application of Proceeds.

              An "Event of Default" as defined in the Loan Agreement shall be an
                  Event of Default hereunder.

              Upon the occurrence of any Event of Default, Bank may at its
                  discretion and without prior notice to Debtor declare any or
                  all of the indebtedness to be immediately due and payable, and
                  shall have and may exercise any one or more of the following
                  rights and remedies:

                  Exercise all the rights and remedies upon Default, in
                      foreclosure and otherwise, available to secured parties
                      under the provisions of the Uniform Commercial Code and
                      other applicable law;

                  Institutelegal proceedings to foreclose upon the lien and
                      security interest granted by this Agreement, to recover
                      judgment for all amounts then due and owing as
                      Indebtedness, and to collect the same out of any
                      Collateral or the proceeds of any sale of it;

<PAGE>

                  Institutelegal proceedings for the sale, under the judgment
                           or decree of any court of competent jurisdiction, of
                           any or all Collateral; and/or

                  Personally or by agents, attorneys, or appointment of a
                           receiver, enter upon any premises where Collateral
                           may then be located, and take possession of all or
                           any of it and/or render it unusable; and without
                           being responsible for loss or damage to such
                           Collateral, hold, operate, sell, lease, or dispose of
                           all or any Collateral at one or more public or
                           private sales, leasings or other dispositions, at
                           places and it on terms and conditions as Bank may
                           deem fit, without any previous demand or
                           advertisement; and except as provided in this
                           Agreement, all notice of sale, lease or other
                           disposition, and advertisement, and other notice or
                           demand, any right or equity of redemption, and any
                           obligation of a prospective purchaser or lessee to
                           inquire as to the power and authority of Bank to
                           sell, lease, or otherwise dispose of the Collateral
                           or as to the application by Bank of the proceeds of
                           sale or otherwise, which would otherwise be required
                           by, or available to Debtor under, applicable law are
                           expressly waived by Debtor to the fullest extent
                           permitted.

                           At any sale pursuant to this Section 4.2, whether
                           under the power of sale, by virtue of judicial
                           proceedings or otherwise, it shall not be necessary
                           for Bank or a public officer under order of a court
                           to have present physical or constructive possession
                           of Collateral to be sold. The recitals contained in
                           any conveyances and receipts made and given by Bank
                           or the public officer to any purchaser at any sale
                           made pursuant to this Agreement shall, to the extent
                           permitted by applicable law, conclusively establish
                           the truth and accuracy of the matters stated
                           (including, without limit, as to the amounts of the
                           principal of and interest on the Indebtedness, the
                           accrual and nonpayment of it and advertisement and
                           conduct of the sale); and all prerequisites to the
                           sale shall be presumed to have been satisfied and
                           performed. Upon any sale of any Collateral, the
                           receipt of the officer making the sale under judicial
                           proceedings or of Bank shall be sufficient discharge
                           to the purchaser for the purchase money, and the
                           purchaser shall not be obligated to see to the
                           application of the money. Any sale of any Collateral
                           under this Agreement shall be a perpetual bar against
                           Debtor with respect to that Collateral. At any sale
                           or other disposition of the Collateral pursuant to
                           this Section 4.2, Bank disclaims all warranties which
                           would otherwise be given under the Uniform Commercial
                           Code, including without limit a disclaimer of any
                           warranty relating to title, possession, quiet
                           enjoyment or the like, and Bank may communicate these
                           disclaimers to a purchaser at such disposition. This
                           disclaimer of warranties will not render the sale
                           commercially unreasonable.

             Upon the occurrence and during the continuance of an Event of
                  Default, debtor shall at the request of Bank, notify the
                  account debtors or obligors of Bank's security interest in the
                  Collateral and direct payment of it to Bank. Bank may, itself,
                  upon the occurrence and during the continuance of any Event of
                  Default so notify and direct any account debtor or obligor. At
                  the reasonable request of Bank, whether or not an Event of
                  Default shall have occurred, Debtor shall immediately take
                  such actions as the Bank shall request to establish exclusive
                  control (as defined in the Uniform Commercial Code) by Bank
                  over any Collateral which is of such a nature that perfection
                  of a security interest may be accomplished by control.

              The proceeds of any sale or other disposition of Collateral
                  authorized by this Agreement shall be applied by Bank first
                  upon all expenses authorized by the Uniform Commercial Code
                  and all reasonable attorney fees and legal expenses incurred
                  by

<PAGE>

                  Bank; the balance of the proceeds of the sale or other
                  disposition shall be applied in the payment of the
                  Indebtedness, first to interest, then to principal, then to
                  remaining Indebtedness and the surplus, if any, shall be paid
                  over to Debtor or to such other person(s) as may be entitled
                  to it under applicable law. Debtor shall remain liable for any
                  deficiency, which it shall pay to Bank immediately upon
                  demand. Debtor agrees that Secured Party shall be under no
                  obligation to accept any noncash proceeds in connection with
                  any sale or disposition of Collateral unless failure to do so
                  would be commercially unreasonable. If Secured Party agrees in
                  its sole discretion to accept noncash proceeds (unless the
                  failure to do so would be commercially unreasonable), Secured
                  Party may ascribe any commercially reasonable value to such
                  proceeds. Without limiting the foregoing, Secured Party may
                  apply any discount factor in determining the present value of
                  proceeds to be received in the future or may elect to apply
                  proceeds to be received in the future only as and when such
                  proceeds are actually received in cash by Secured Party.

              Nothing in this Agreement is intended, nor shall it be construed,
                  to preclude Bank from pursuing any other remedy provided by
                  law for the collection of the Indebtedness or for the recovery
                  of any other sum to which Bank may be entitled for the breach
                  of this Agreement by Debtor. Nothing in this Agreement shall
                  reduce or release in any way any rights or security interests
                  of Bank contained in any existing agreement between Borrower,
                  Debtor, or any Guarantor and Bank.

              No waiver of Default or consent to any act by Debtor shall be
                  effective unless in writing and signed by an authorized
                  officer of Bank. No waiver of any Default or forbearance on
                  the part of Bank in enforcing any of its rights under this
                  Agreement shall operate as a waiver of any other Default or of
                  the same Default on a future occasion or of any rights.

              Debtor hereby (a) irrevocably appoints Bank or any agent of Bank
                  (which appointment is coupled with an interest) the true and
                  lawful attorney of Debtor (with full power of substitution) in
                  the name, place and stead of, and at the expense of, Debtor
                  and (b) authorizes Bank or any agent of Bank, in its own name,
                  at Debtor's expense, to do any of the following at any time
                  (upon the occurrence and during the continuance of an Event of
                  Default), as Bank, in its sole discretion, deems appropriate:

                  to demand, receive, sue for, and give receipts or acquittances
                        for any moneys due or to become due on any Collateral
                        and to endorse any item representing any payment on or
                        proceeds of the Collateral;

                  to execute and file in the name of and on behalf of Debtor all
                        financing statements or other filings deemed necessary
                        or desirable by Bank to evidence, perfect, or continue
                        the security interests granted in this Agreement; and

                  to do and perform any act on behalf of Debtor permitted or
                        required under this Agreement.

              Upon the occurrence and during the continuance of an Event of
                  Default, Debtor also agrees, upon request of Bank, to assemble
                  the Collateral and make it available to

<PAGE>

                  Bank at any place designated by Bank which is reasonably
                  convenient to Bank and Debtor.

              The following shall be the basis for any finder of fact's
                  determination of the value of any Collateral which is the
                  subject matter of a disposition giving rise to a calculation
                  of any surplus or deficiency under Section 9615(f) of the
                  Uniform Commercial Code (as in effect on or after July 1,
                  2001): (a) The Collateral which is the subject matter of the
                  disposition shall be valued in an "as is" condition as of the
                  date of the disposition, without any assumption or expectation
                  that such Collateral wilt be repaired or improved in any
                  manner; (b) the valuation shall be based upon an assumption
                  that the transferee of such Collateral desires a resale of the
                  Collateral for cash promptly (but no later than 30 days)
                  following the disposition; (c) all reasonable closing costs
                  customarily borne by the seller in commercial sales
                  transactions relating to property similar to such Collateral
                  shall be deducted including, without limitation, brokerage
                  commissions, tax prorations, attorney's fees, whether inside
                  or outside counsel is used, and marketing costs; (d) the value
                  of the Collateral which is the subject matter of the
                  disposition shall be further discounted to account for any
                  estimated holding costs associated with maintaining such
                  Collateral pending sale (to the extent not accounted for in
                  (c) above), and other maintenance, operational and ownership
                  expenses; and (e) any expert opinion testimony given or
                  considered in connection with a determination of the value of
                  such Collateral must be given by persons having at least 5
                  years experience in appraising property similar to the
                  Collateral and who have conducted and prepared a complete
                  written appraisal of such Collateral taking into consideration
                  the factors set forth above. The "value" of any such
                  Collateral shall be a factor in determining the amount of
                  proceeds which would have been realized in a disposition to a
                  transferee other than a secured party, a person related to a
                  secured party or a secondary obligor under Section 9615(f) of
                  the Uniform Commercial Code.

Miscellaneous.

              Until Bank is advised in writing by Debtor to the contrary, all
                  notices, requests and demands required under this Agreement or
                  by law shall be given to, or made upon, Debtor at the first
                  address indicated in Section 5.15 below.

              Debtor wilt give Bank not less than 30 days' prior written notice
                  of all contemplated changes in Debtor's name, location, chief
                  executive office, principal place of business, and/or location
                  of any Collateral (other than the Sales of Inventory in the
                  ordinary course of business), but the giving of this notice
                  shall not cure any Event of Default caused by this change.

              Bank assumes no duty of performance or other responsibility under
                  any contracts contained within the Collateral.

              Bank has the right to sell, assign, transfer, negotiate or grant
                  participations or any interest in, any or all of the
                  Indebtedness and any related obligations, including without

<PAGE>

                  limit this Agreement. in connection with the above, but
                  without limiting its ability to make other disclosures to the
                  full extent allowable, Bank may disclose all documents and
                  information which Bank now or later has relating to Debtor,
                  the Indebtedness or this Agreement, however obtained, subject
                  to the terms of the Confidentiality Agreement. Debtor further
                  agrees that Bank may provide information relating to this
                  Agreement or relating to Debtor to the Bank's parent,
                  affiliates, subsidiaries, and service providers.

         In addition to Bank's other rights, any indebtedness owing from Bank to
                  Debtor can be set off and applied by Bank on any Indebtedness
                  at any time(s) either before or after maturity or demand
                  without notice to anyone. Any such action shall not constitute
                  acceptance of collateral in discharge of any portion of the
                  Indebtedness.

         [Intentionally Omitted.]

         [Intentionally Omitted.]

         In the event that applicable law shall obligate Bank to give prior
                  notice to Debtor of any action to be taken under this
                  Agreement, Debtor agrees that a written notice given to Debtor
                  at least ten days before the date of the act shall be
                  reasonable notice of the act and, specifically, reasonable
                  notification of the time and place of any public sale or of
                  the time after which any private sale, lease, or other
                  disposition is to be made, unless a shorter notice period is
                  reasonable under the circumstances. A notice shall be deemed
                  to be given under this Agreement when delivered to Debtor or
                  when placed in an envelope addressed to Debtor and deposited,
                  with postage prepaid, in a post office or official depository
                  under the exclusive care and custody of the United States
                  Postal Service or delivered to an overnight courier. The
                  mailing shall be by overnight courier, certified, or first
                  class mail.

         Notwithstanding any prior revocation, termination, surrender, or
                  discharge of this Agreement in whole or in part, the
                  effectiveness of this Agreement shall automatically continue
                  or be reinstated in the event that any payment received or
                  credit given by Bank in respect of the Indebtedness is
                  returned, disgorged, or rescinded under any applicable law,
                  including, without limitation, bankruptcy or insolvency laws,
                  in which case this Agreement, shall be enforceable against
                  Debtor as if the returned, disgorged, or rescinded payment or
                  credit had not been received or given by Bank, and whether or
                  not Bank relied upon this payment or credit or changed its
                  position as a consequence of it. In the event of continuation
                  or reinstatement of this Agreement, Debtor agrees upon demand
                  by Bank to execute and deliver to Bank those documents which
                  Bank determines are appropriate to further evidence (in the
                  public records or otherwise) this continuation or
                  reinstatement, although the failure of Debtor to do so shall
                  not affect in any way the reinstatement or continuation.

         This Agreement and all the rights and remedies of Bank under this
                  Agreement shall inure to the benefit of Bank's successors and
                  assigns and to any other holder who derives from Bank title to
                  or an interest in the Indebtedness or any portion of it,

<PAGE>

       and shall bind Debtor and the heirs, legal representatives, successors,
       and assigns of Debtor. Nothing in this Section 5.10 is deemed a consent
       by Bank to any assignment by Debtor.

[Intentionally Omitted.]

Except as otherwise provided in this Agreement, all terms in this Agreement have
       the meanings assigned to them in Division 9 (or, absent definition in
       Division 9, in any other Division) of the Uniform Commercial Code, as
       those meanings may be amended, revised or replaced from time to time.
       "Uniform Commercial Code', means the California Uniform Commercial Code,
       as amended.

No single or partial exercise, or delay in the exercise, of any right or power
       under this Agreement, shall preclude other or further exercise of the
       rights and powers under this Agreement. The unenforceability of any
       provision of this Agreement shall not affect the enforceability of the
       remainder of this Agreement. This Agreement constitutes the entire
       agreement of Debtor and Bank with respect to the subject matter of this
       Agreement. No amendment or modification of this Agreement shall be
       effective unless the same shall be in writing and signed by Debtor and an
       authorized officer of Bank. THIS AGREEMENT SHALL BE GOVERNED BY AND
       CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF
       CALIFORNIA, WITHOUT REGARD TO CONFLICT OF LAWS PRINCIPALS.

To the extent that any of the Indebtedness is payable upon demand, nothing
       contained in this Agreement shall modify the terms and conditions of that
       Indebtedness nor shall anything contained in this Agreement prevent Bank
       from making demand, without notice and with or without reason, for
       immediate payment of any or all of that Indebtedness at any time(s),
       whether or not an Event of Default has occurred.

Debtor represents and warrants that:

       Debtor's exact name is the name set forth in this Agreement. Debtor
               further represents and warrants the following and agrees that
               Debtor is, and at all times shall be a registered organization
               which is organized under the laws of the State of Delaware; and

       Except as to Inventory which in the ordinary course of Debtor's business
               is in the hands of Debtor's agents or direct sales
               representatives or held for use by hospitals, the Collateral is
               located and shall be maintained only at the locations identified
               in Schedule A attached hereto. Debtor, from time to time, at the
               request of Bank will provide Bank with an updated list of its
               agents and direct sales representatives.

This Agreement shall be terminated only by the authorized filing of a
       termination statement in accordance with the applicable provisions of the
       Uniform Commercial Code, but the obligations contained in Section 2.13 of
       this Agreement shall survive termination.

<PAGE>

       Debtor agrees to reimburse the Bank upon demand for any and all costs and
               expenses (including, without limit, court costs, legal expenses
               and reasonable attorneys, fees, whether inside or outside counsel
               is used, whether or not suit is instituted and, if suit is
               instituted, whether at the trial court level, appellate level `
               in a bankruptcy, probate or administrative proceeding or
               otherwise) incurred in enforcing or attempting to enforce this
               Agreement or in exercising or attempting to exercise any right or
               remedy under this Agreement or incurred in any other matter or
               proceeding relating to this Security Agreement.

       As used herein, "Loan Agreement" means that certain Business Loan
               Agreement, dated as of even date herewith, between Debtor and
               Bank, as the same may be amended or restated from time to time in
               accordance with its terms. All initially capitalized terms used
               but not defined herein have the meanings given to such terms in
               the Loan Agreement.

DEBTOR AND BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL
       ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER CONSULTING (OR HAVING
       HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR CHOICE, KNOWINGLY
       AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT WAIVES ANY RIGHT TO TRIAL
       BY JURY IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE OR
       ENFORCEMENT OF, OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE
       INDEBTEDNESS.

                                  DEBTOR:     Interpore International, Inc.
                                         ---------------------------------------
                                              DEBTOR NAME TYPED/PRINTED

                                  By:___________________________________________
                                          SIGNATURE OF

                                  Its:__________________________________________
                                          TITLE (If applicable)

                                  By:___________________________________________
                                          SIGNATURE OF

                                  Its:__________________________________________
                                          TITLE (If applicable)

Borrower(s):

Interpore International, Inc.

<PAGE>

[LOGO]

                    INTELLECTUAL PROPERTY SECURITY AGREEMENT

     This Intellectual Property Security Agreement (the "Agreement") is made as
of June 14, 2002, by and between INTERPORE INTERNATIONAL, INC., a Delaware
corporation ("Grantor"), and COMERICA BANK-CALIFORNIA, a California banking
corporation ("Secured Party").

                                    RECITALS

     A.   Secured Party has agreed to lend to Grantor certain funds (the "Loan")
and Grantor desires to borrow such funds from Secured Party pursuant to the
terms of a Master Revolving Note and a Business Loan Agreement, each dated of
even date herewith (the "Loan Documents"). All capitalized terms used herein
without definition shall have the meanings ascribed to them in the Loan
Documents.

     B.   In order to induce Secured Party to make the Loan, Grantor has agreed
to assign certain intangible property to Secured Party for purposes of securing
the obligations of Grantor to Secured Party.

     NOW, THEREFORE, THE PARTIES HERETO AGREE AS FOLLOWS:

     28.  Grant of Security Interest. As collateral security for the prompt and
complete payment and performance of all of Grantor's present or future
indebtedness, obligations and liabilities to Secured Party, Grantor hereby
grants a security interest and mortgage to Secured Party, as security, in and to
Grantor's entire right, title and interest in, to and under the following (all
of which shall collectively be called the "Collateral"):

          (a)  Any and all copyright rights, copyright applications, copyright
registrations and like protections in each work or authorship and derivative
work thereof, whether published or unpublished and whether or not the same also
constitutes a trade secret, now or hereafter existing, created, acquired or
held, including without limitation those set forth on Exhibit A attached hereto
(collectively, the "Copyrights");

          (b)  Any and all trade secrets, and any and all intellectual property
rights in computer software and computer software products now or hereafter
existing, created, acquired or held;

          (c)  Any and all design rights which may be available to Grantor now
or hereafter existing, created, acquired or held;

          (d)  All patents, patent applications and like protections including,
without limitation, improvements, divisions, continuations, renewals, reissues,
extensions and

<PAGE>

continuations-in-part of the same, including without limitation the patents and
patent applications set forth on Exhibit B attached hereto (collectively, the
"Patents");

          (e)  Any trademark and servicemark rights, whether registered or not,
applications to register and registrations of the same and like protections, and
the entire goodwill of the business of Grantor connected with and symbolized by
such trademarks, including without limitation those set forth on Exhibit C
attached hereto (collectively, the "Trademarks");

          (f)  Any and all claims for damages by way of past, present and future
infringement of any of the rights included above, with the right, but not the
obligation, to sue for and collect such damages for said use or infringement of
the intellectual property rights identified above;

          (g)  All licenses or other rights to use any of the Copyrights,
Patents or Trademarks, and all license fees and royalties arising from such use
to the extent permitted by such license or rights; and

          (h)  All amendments, extensions, renewals and extensions of any of the
Copyrights, Trademarks or Patents; and

          (i)  All proceeds and products of the foregoing, including without
limitation all payments under insurance or any indemnity or warranty payable in
respect of any of the foregoing.

     29.  Authorization and Request. Grantor authorizes and requests that the
Register of Copyrights and the Commissioner of Patents and Trademarks record
this security agreement.

     30.  Covenants and Warranties. Grantor represents, warrants, covenants and
agrees as follows:

          (a)  Grantor is now the sole owner of the Collateral, except for
licenses granted by Grantor to its customers in the ordinary course of business;

          (b)  Performance of this Agreement does not conflict with or result in
a breach of any material agreement to which Grantor is party or by which Grantor
is bound, except to the extent that certain intellectual property agreements
prohibit the assignment of the rights thereunder to a third party without the
licensor's or other party's consent and this Agreement constitutes an
assignment;

          (c)  During the term of this Agreement, Grantor will not transfer or
otherwise encumber any interest in the Collateral, except for licenses granted
by Grantor in the ordinary course of business, or as set forth in this
Agreement;

          (d)  Each of the Patents is valid and enforceable, and no part of the
Collateral has been judged invalid or unenforceable, in whole or in part, and no
claim has been made that any part of the Collateral violates the rights of any
third party;

<PAGE>

          (e)  Grantor shall deliver to Secured Party within thirty (30) days of
the last day of each fiscal year, a report signed by Grantor, in form reasonably
acceptable to Secured Party, listing any applications or registrations that
Grantor has made or filed in respect of any patents, copyrights or trademarks
and the status of any outstanding applications or registrations. Grantor shall
promptly advise Secured Party of any material change in the composition of the
Collateral, including but not limited to any subsequent ownership right of the
Grantor in or to any Trademark, Patent or Copyright not specified in this
Agreement;

          (f)  Grantor shall (i) protect, defend and maintain the validity and
enforceability of the Trademarks, Patents and Copyrights, and (ii) not allow any
Trademarks, Patents or Copyrights to be abandoned, forfeited or dedicated to the
public without the written consent of Secured Party, which shall not be
unreasonably withheld, unless Grantor determines that reasonable business
practices suggest that abandonment is appropriate;

          (g)  Grantor shall, from time to time, execute and file such other
instruments, and take such further actions as Secured Party may reasonably
request from time to time to perfect or continue the perfection of Secured
Party's interest in the Collateral;

          (h)  This Agreement creates, and in the case of after acquired
Collateral, this Agreement will create at the time Grantor first has rights in
such after acquired Collateral, in favor of Secured Party a valid and perfected
first priority security interest in the Collateral in the United States, subject
only to Permitted Liens, securing the payment and performance of the obligations
evidenced by the Loan Documents upon making the filings referred to in clause
(i) below;

          (i)  Except for, and upon, the filing of a Financing Statement (Form
UCC-1) with the Secretary of State of the State of Delaware and the filing with
the United States Patent and Trademark office with respect to the Patents and
Trademarks and the Register of Copyrights with respect to the Copyrights
necessary to perfect the security interests created hereunder, and, except as
has been already made or obtained, no authorization, approval or other action
by, and no notice to or filing with, any U.S. governmental authority or U.S.
regulatory body is required either (i) for the grant by Grantor of the security
interest granted hereby or for the execution, delivery or performance of this
Agreement by Grantor in the U.S. or (ii) for the perfection in the United States
or the exercise by Secured Party of its rights and remedies hereunder;

          (j)  All information heretofore, herein or hereafter supplied to
Secured Party by or on behalf of Grantor with respect to the Collateral is
accurate and complete in all material respects.

          (k)  Grantor shall not enter into any agreement that would materially
impair or conflict with Grantor's obligations hereunder without Secured Party's
prior written consent, which consent shall not be unreasonably withheld. Grantor
shall not permit the inclusion in any material contract to which it becomes a
party of any provisions that could or might in any way prevent the creation of a
security interest in Grantor's rights and interests in any property included
within the definition of the Collateral acquired under such contracts, except
that certain contracts may contain anti-assignment provisions that could in
effect prohibit the creation of a

<PAGE>

security interest in such contracts if Grantor is required, in its commercially
reasonable judgment to accept such provisions; and

         (l) Upon any executive officer of Grantor obtaining knowledge thereof,
Grantor will promptly notify Secured Party in writing of any event that
materially adversely affects the value of any of the Collateral, the ability of
Grantor to dispose of any Collateral or the rights and remedies of Secured Party
in relation thereto, including the levy of any legal process against any of the
Collateral.

     31. Secured Party's Rights. Secured Party shall have the right, but not the
obligation, to take, at Grantor's sole expense, any actions that Grantor is
required under this Agreement to take but which Grantor fails to take, after
fifteen (15) days' notice to Grantor. Grantor shall reimburse and indemnify
Secured Party for all reasonable costs and expenses incurred in the reasonable
exercise of its rights under this section 4.

     32. Inspection Rights. Grantor hereby grants to Secured Party and its
employees, representatives and agents the right to visit, during reasonable
hours upon prior reasonable written notice to Grantor, any of Grantor's plants
and facilities that manufacture, install or store products (or that have done so
during the prior six-month period) that are sold utilizing any of the
Collateral, and to inspect the products and quality control records relating
thereto upon reasonable notice to Grantor and as often as may be reasonably
requested.

     33. Further Assurances; Attorney in Fact.

         (a) On a continuing basis, Grantor will make, execute, acknowledge and
deliver, and file and record in the proper filing and recording places in the
United States, all such instruments, including, appropriate financing and
continuation statements and collateral agreements and filings with the United
States Patent and Trademark Office and the Register of Copyrights, and take all
such action as may reasonably be deemed necessary or advisable, or as requested
by Secured Party, to perfect Secured Party's security interest in all
Copyrights, Patents and Trademarks and otherwise to carry out the intent and
purposes of this Agreement, or for assuring and confirming to Secured Party the
grant or perfection of a security interest in all Collateral.

         (b) Grantor hereby irrevocably appoints Secured Party as Grantor's
attorney-in-fact, with full authority in the place and stead of Grantor and in
the name of Grantor, from time to time upon the occurrence and during the
continuance of an Event of Default in Secured Party's discretion, to take any
action and to execute any instrument which Secured Party may deem necessary or
advisable to accomplish the purposes of this Agreement, including:

             (1) To modify, in its sole discretion, this Agreement without
first obtaining Grantor's approval of or signature to such modification by
amending Exhibit A, Exhibit B and Exhibit C, hereof, as appropriate, to include
reference to any right, title or interest in any Copyrights, Patents or
Trademarks acquired by Grantor after the execution hereof or to delete any
reference to any right, title or interest in any Copyrights, Patents or
Trademarks in which Grantor no longer has or claims any right, title or
interest;

<PAGE>

               (2) To file, in its sole discretion, one or more financing or
continuation statements and amendments thereto, relative to any of the
Collateral without the signature of Grantor where permitted by law; and

               (3) To transfer the Collateral into the name of Secured Party or
a third party to the extent permitted under the California Uniform Commercial
Code.

     34. Events of Default. The occurrence of any Event of Default (as defined
in the Loan Documents) shall constitute an Event of Default under this
Agreement.

     35. Remedies. Upon the occurrence and during the continuance of an Event of
Default, Secured Party shall have the right to exercise all the remedies of a
secured party under the California Uniform Commercial Code, including without
limitation the right to require Grantor to assemble the Collateral and any
tangible property in which Secured Party has a security interest and to make it
available to Secured Party at a place designated by Secured Party. Secured Party
shall have a nonexclusive, royalty free license to use the Copyrights, Patents
and Trademarks to the extent reasonably necessary to permit Secured Party to
exercise its rights and remedies upon the occurrence of an Event of Default.
Grantor will pay any expenses (including reasonable attorneys' fees) incurred by
Secured Party in connection with the exercise of any of Secured Party's rights
hereunder, including without limitation any expense incurred in disposing of the
Collateral. All of Secured Party's rights and remedies with respect to the
Collateral shall be cumulative.

     36. Indemnity. Grantor agrees to defend, indemnify and hold harmless
Secured Party and its officers, employees, and agents against: (a) all
obligations, demands, claims, and liabilities claimed or asserted by any other
party in connection with the transactions contemplated by this Agreement, and
(b) all losses or expenses in any way suffered, incurred, or paid by Secured
Party as a result of or in any way arising out of, following or consequential to
transactions between Secured Party and Grantor, whether under this Agreement or
otherwise (including without limitation attorneys fees and expenses), except for
losses arising from or out of Secured Party's gross negligence or willful
misconduct.

     37. Course of Dealing. No course of dealing, nor any failure to exercise,
nor any delay in exercising any right, power or privilege hereunder shall
operate as a waiver thereof.

     38. Attorneys Fees. If any action relating to this Agreement is brought by
either party hereto against the other party, the prevailing party shall be
entitled to recover reasonable attorneys fees, costs and disbursements.

     39. Amendments. This Agreement may be amended only by a written instrument
signed by both parties hereto.

     40. Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original but all of which
together shall constitute the same instrument.

     41. California Law and Jurisdiction; Jury Waiver. This Agreement shall be
governed by the laws of the State of California, without regard for choice of
law provisions. Grantor and

<PAGE>

Secured Party consent to the exclusive jurisdiction of any state or federal
court located in Santa Clara County, California. GRANTOR AND SECURED PARTY EACH
WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION
BASED UPON OR ARISING OUT OF THE LOAN DOCUMENTS, THIS AGREEMENT, OR

<PAGE>

ANY OF THE TRANSACTIONS CONTEMPLATED HEREIN, INCLUDING CONTRACT CLAIMS, TORT
CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS.

                                      * * *

                [remainder of this page intentionally left blank]

                                      * * *

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the
day and year first above written.

Address of Grantor:                             GRANTOR:
181 Technology Dr
Irvine, CA 92618                                Interpore International, Inc., a
                                                Delaware corporation

                                                By:_____________________________

                                                Name:___________________________

                                                Its:____________________________

                                                By:_____________________________

                                                Name:___________________________

                                                Its:____________________________

Address of Secured Party:                       SECURED PARTY:

75 E. Trimble Road                              Comerica Bank-California, a
San Jose, CA.  95131                            California Banking corporation

                                                By:_____________________________
                                                         Dan McGregor
                                                Title:   Vice PresidentEXHIBIT 10.9

                    GREENERY E'XECUTIVE SUITES LEASE

This lease is made and entered into on 1/30/02 and between the GREENERY
EXECUTIVE SUITES, (herein after referred to as "Lessor"), and Amerimmune
Pharmaceuticals, Inc. (herein after referred to as "Lessee").

1.   DESCRIPTION OF PREMISES. Premises shall consist of Suite Number A-40
     at 920 Hampshire Road, Westlake Village, CA 91361-2815. (Designated
     suite(s) is outlined on the attached floor plan as Exhibit A). In
     addition, Lessee shall have use of the common areas including the
     lobby and conference rooms to be shared with all other tenants. The
     Greenery Executive Suites building is a non-smoking building.
     Smoking is Permitted outside in the atrium areas.

2.   TERM. The term of this Lease is 12 Months, commencing 2/1/02 and
     3/31/03 unless terminated sooner as herein provided.

3.   RENEWAL. Lessee agrees that  it shall give Lessor thirty (30) days
     written notice, return receipt requested, of Lessee's intention to
     vacate this premises at the expiration of the aforementioned term.
     In the event Lessor does not receive said notice prior to thirty
     (30) days as provided herein, Lease shall be renewed for an
     additional period equal to the original term subject to the same
     covenants and conditions as contained herein. In addition to the
     right of Lessor to terminate this Lease Agreement as otherwise
     provided herein, Lessor shall also have the right, irrespective of
     Lessee's rights, to terminate this Lease Agreement at the end of the
     original term or any renewal term as provided herein by giving
     written notice of such intention to terminate Lease, return receipt
     requested, at least thirty (30) days prior to the ending date of the
     original term or any renewal tenn as provided herein.

4.   USE. Lessee shall use the premises for the following specific
     purpose of general office business, and shall not use or permit the
     premises to be used for any other purpose without prior written
     collsent of Lessor. For so long as Lessee shall comply with the
     provisions, conditions and covenants of this Lease, Lessor also
     warrants and guarantees that Lessee shall have full enjoyment and
     peaceable possession of the Premises for the use stated herin
     without hindrance or interruption at all times during the term of
     this leas.

5.   RENT.  Lessee agrees to pay to lessor, without prior noticc or
     demand, for the premises, the sum, $ 1,450. 00 on or before the
     first (1st) day of each and every successive calendar month
     thereafter during the term hereof, except that the first

                                                            Initial _____
                                                                    _____

                                    1
<PAGE>
     month's rent shall be paid upon the execution hereof. Rent for any
     period during the term hereof which is for less that one (1) month
     shall be prorated portion of the monthly installment herein based
     upon a thirty (30) day month.  Said rent shall be paid directly to
     Lessor without deduction or offset, in lawful money of the United
     States of America.  If the rent is not received by the Lessor within
     ten (10) days from when the rent is due and payable as provided
     herein, Lessee shall pay to Lessor, a late fee in the amount of
     twenty-five dollars ($25.00) payable immediately thereafter.  The
     late fee is payable without prejudice to Lessor to exercise any
     other rights or Remedies if Lessee fails to pay his rent.  In the
     event rental is not paid in a timely fashion, landlord may deny use
     of common areas until payent is made pursuant to this lease.

     This is a gross lease. The Lessor pays for utilities including gas,
     electrical and water.  The Lessee pays for his/her own telephone
     bill. Lessor shall provide building standard janitorial services
     five times per week (unless national holiday occurs).

     Upon execution of Lease, Lessee shall pay to Lessor $ 2, 900. 00
     representing rent for first and last months.
     If the specified term of this Lease is for more than (1) year, rent
     for the second year and each succeeding year of this Lease shall be
     increased by the Consumer Price Index (CAP.) percent.  The Consumer
     Price Index will be the All Urban Consumers, All Items, Los
     Angeles-Long Beach-Anaheim Metropolitan Areas, compiled by the
     Department of Labor.  Said Consumer Price Index compiled for the
     month which is two months prior to the month of commencement date,
     shall be the basic index.  The adjustment will be make for the prior
     twelve (12) month period.

6.   SECURITY DEPOSIT. An additional deposit of $200.00 for any expenses
     caused by Lessee, including but not limiited to damages, cleaning,
     painting and unpaid rent or other fees, shall be deposited with
     Lessor upon execution of Lease. Total monies due upon execution of
     Lease (security deposit plus advance rent) S3,JDQ,0o , plus any
     pro-rata due. The Security Deposit is fully refundable, ifno
     expenses are incurred by the Lessor. Lessor shall be held
     responsible for damages it causes and Lessor shall leave the
     premises in similar condition as they are at lease inspection, less
     ordinary wear and tear, repairs and/or cleanup from casualty.

                                                            Initial _____
                                                                    _____
                                    2
<PAGE>
     RECEPTION AREA AND RECEPTIONIST. A furnished Commoll area shall be
     provided for the purpose of receiving clients, customers, and guests
     of Lessee whoare awaiting appointments or meetings with Lessee,
     Lessor shall provide a receptionist *in said area from 8:30 a.m. to
     5:00 p.m., Mondays through Fridays, Holidays excluded, for the
     purpose of greeting such clients~. customers and guests and to
     promptly inform Lessee or its agents of their presence.

     b) ANSWERING SERVICE AND VOICE MAIL. Lessor shall provide one person
     to answer, incoming telephone calls of Lessee during, office hours
     as stated above in subparagraph (a) and to promptly forward messages
     to the Lessee, its agents, or voice mail box. Lessee will pay for
     all  fees necessary  for the installation of telephone
     communications in Lessor's Suite for the purpose of receiving
     outsidt calls. It is necessary to have a telephone that is
     compatible with Lessor's telephone system. GTE will bill each tenant
     for their lines installed and bill each tenant for their monthly
     phone charges.

     c) SECRETARIAL SERVICE. - The Greenery Executive Suites will ensure
     that a secretarial support service is maintained on the premises.
     This service shall provide word processing, copying, and faxing for
     a fee, on a first come basis. Fees will be negotiated directly with
     the secretarial service. Each user of the secretarial service shall
     be solely liable for the accuracy of their corrununications and/or
     coiTespondence and shall hold Greenery Executive suites and the
     secretarial service harmless from any dainages as a result of
     inaccuracy Or errors.

     d) CONFERENCE ROOM. Lessor shall provide one or more conference
     rooms for the purpose of handling conferences or meetings staged by
     Lessee. Said conference room(s) will be available on a first-come,
     first-served basis through prior arrangement with the Lessor's
     receptionist or designated agent Lessor reserves the right, from
     time to time, to institute and/or change the rules and regulations
     relating to the use of the conference room(s). The rules and
     regulations established, from time to time, are hereto incorporated
     into this Lease and the breach of such rules and regulations shall
     be deemed a breach of this Lease.
                                                            Initial _____
                                                                    _____
                                    3
<PAGE>
8    PROHBITIVE USES:  Lessee shall not Commit or permit the commission
     of any acts on said premises in  any way that:

     a) Will increase the existing rates or cause cancellation  of any
     fire, casualtly, liability, or . other insurance poli cy insuring
     the building or its contents;

     b) Violates or conflicts with any law, statute, ordinance or
     government rule or regulation, whether now in force or hereinafter
     enacted, governing said premises or the building,

     c) Obstructs or interferes with the rights of other tenants or
     occupants of the building or injures or annoys them;

     d) Constitutes the commission of waste on said premises or the
     conunission or maintenance of a nuisance as defined by the laws of
     the State of California;

     e) Violates the rules and regulations established, from
     time-to-time, by Lessor to govern the use of the common areas of the
     Greenery Executive Suites, including, but not limited to, the lobby
     and conference room(s).

     f) Interfere with the operation of the suite by the Lessor or
     interferes, with the business of the other tenants of the suite.

     g) Any commission of the foregoing prohibited acts as set forth
     above shall be considered a material breach of this Agreement.

9.   ALTERATIONS, IMPROVEMENTS OR ADDITIONS/CARE OF PREMISES.
     Lessee shall not make any alterations, improvements or additions to
     the premises without obtaining the written permission of the Lessor
     such as shelving, wall covering or locks. Lessee shall take good
     care not to cause damage to the premises and, at the expiration of
     this Lease, shall deliver the premises to Lessor in as good
     condition as when received by Lessee, repairs that are the
     responsibility of Lessor, damage from casualty, and reasonable use
     and wear expected.

10.  MAINTENANCE AND REPAIRS. Lessor shall deliver possession of the
     premises in good sanitary order, condition and repair. Lessee shall
     exercise due care not to cause damage to the premises and every part
     thereof, damage thereto from causes beyond the reasonable control of
     lessee and ordinary wear and tear excepted.  Lessee shall, upon the
     expiration or sooner termination of this Lease

                                                            Initial _____
                                                                    _____
                                    4
<PAGE>
     hereof surrender the premises, to the Lessor in good Condition,
     ordingry wear and tear, repairs Which are thc responsibility of
     lessor, damages from casualty,a nd damage from causes beyond the
     resonable control of  lessee excepted. Lessee shall not be
     responsible for any repairs to the structure, mechanical,
     electrical, plumbing, sprinklers, and the like systems. If Lessee
     has given notice to terminate or Lessee is in default of rental
     payments, Lessor's receptionist or authorized agent may show the
     premises, with advance notice, to prospective tenants between the
     hours of 9:00 a.m. and 5:00 p.m., Monday through Friday. Lessor
     agrees to keep the building of which the premises are a part, the
     premises and the cormnon areas in clean order, first-class operating
     condition and in good repair at all times during this Lease.

11.  ASSIGNMENT AND-SUBLETTING.  Lessee shall not either voluntarily or
     by operati on of law, assign, transfer, mortgage, pledge,
     hypotliecate or encumber this Lease or any interest therein, and
     shall not sublet the said premises or any part thereof, or any right
     or privilege appurtenant thereto or suffer any other person (the
     employees, agents, servants and invites of Lessee excepted) to
     occupy or use the said premises, or any portion thereof, without the
     written consent of Lessor first liand and obtained, which consent
     shall not be uru-easonably withheld, and a consent to one
     assignment, subletting, occupation or use by another person. Any
     such assignment or subletting without such consent shall be void,
     and shall, at the option of the Lessor, constitute a default under
     this Lease.

12.  ATTORNEY'S  FEES. If either party commences litigation in connection
     with the enforcing the terms of this Lease or in the event suit  is
     brought for recovery of any rent due under this Lease or damages by
     the breach of any covenant or condition of this Lease, then the
     prevailing party shall be entitled to recover reasonable attorney's
     fees and court costs from the. other party.

13.  INSURANCE INDEMINTY.  Lessor shall not be liable for any damage to
     property or injury to persons sustained by Lessee or others caused
     by conditions or activities on the premises, unless such conditions
     or activities are proximately caused by Lessor's action or
     negligence. Lessee shall indemnify and hold Lessor harmless against
     any and all claims and damages arising out of Lessee"s use of the
     premises including attorney fees, and shall carry liability
     insurance miuring Lessor and Lessee against any claims in an amount
     of not less than $1,000,000. per occurrence of  bodily injury and
     property damage combined. Lessee shall furnish Lessor with
     certificate of insurance naming the Lessor as an additional named
     insured and shall notify Lessor that such policy is in full force
     and effect within thirty (30) days of the commencement of the lease.
     Lessor will not carry insurance on Lessee's personal property.

                                                            Initial _____
                                                                    _____
                                    5
<PAGE>
14.  RULES AND REGULATIONS. Lessee shall faithfully observe and comply
     with the rules and regulations of the building or those that the
     Lessor shall from time to time, promulgate.  Lessor reserves the
     right, from time to time, to make all resonable modifications to
     said rules. The addlitions to those rules shall be binding upon
     Lessee upon delivery of a copy of them to Lessee. Lessor shall not
     be responsible to Lessee for the non-performance of any said rules
     by and other tenants or occupants but shall proceed with due
     diligence to enforce same.

15.  INABILITY TO DELIVER POSSESSION.  If, as a result of causes beyond
     the Lessor's reasonable control, Lessor is unable to deliver
     possession of the premises by the commencement date, Lessor shall
     not be liable for any damage caused to Lessee thereby. Such delay
     shall not extend the term of this Lease nor shall it make the Lease
     void or violable. Lessee, however, shall not be liable for rent
     until Lessee obtains possession of the Premises. Lessee may elect to
     terminate this Lease immediately upon giving notice in such count or
     at anytime prior to Lessor effecting Possession.

16.  DEFAULTS/REMEDY.  If Lessee defaults or neglects to perform any of
     its obligations under this Lease, then Lessor after reasonable
     notice in writing as set forth, may terminate this Lease, if such
     conditions are not cured within that time. Time is of the essence
     hereof. If any rent or any part thereof shall be and remain unpaid
     when due, or if Lessee violates or defaults in any of the provisions
     of this Lease, then Lessor may terminate this Lease after ten (10)
     days' notice, and re-enter the premises. Notwithstanding any
     re-entry and retaking of possession, Lessee's liability for the rent
     provided herein shall not be extinguished for the balance of the
     term of the Lease.

17.  BINDING ON HEIRS AND SUCCESSORS. This lease shall be binding on and
     shall insure to the benefit of the heirs, executors, administrators,
     successors, and assigns of the parties, Lessor And Lessee, hereto,
     but nothing in this paragraph shall be construed as a consent by
     Lessor to any assignment of Us lease.

18.  WAIVER OF BREACH.The waiver of any breach provision of tbis Lease by
     a party shall not constitute a continuing waiver or a waiver of any
     subsequent breach by the party either of the same or of another
     provision of this Lease.

                                                            Initial _____
                                                                    _____
                                    6
<PAGE>
19.  ACCESS TO PREMISE . Lessee shall permit Lessor access to the
     premises at all reasonable times for the purpose  of inspecting or
     making  repairs. Additions or alterations to the premises..

20.  PARKING  Executive suite tenants are requested. at no charge, to
     park in the lot conveniently located on the west side of the
     complex. Greenery Executive Suites can also provide covered parking
     at no additional charge.

21.  SIGNAGE.  All signs will be provided by the Lessor to identify each
     suite. No additional signs or other forms of advertising will be
     permitted on the doors or windows of the building.

22.  DESTRUCTION OR DAMAGE OF PREMISES.  In the event the premises are
     destroyed or damaged by fire, earthquake, or any other Act of God,
     then this Lease shall terminate without liability, by either Lessor
     or Lessee. Lessor shall, however, promptly make all other repairs to
     the structure and its various systems, so as to maintain the
     habitability of the premises. Failure to do so, is a material breach
     of this Lease entitling Lessee to terminate the lease immediately
     upon written notice with no liability for rent beyond the date of
     occurrence rendering the premises reasonably uninhabitable or fit
     for their purpose as an executive suite.

23.  NOTICES. Except where otherwise required by statute,  all notices
     given pursuant to the provisions hereof may be sent by registered or
     certified mail, postage paid to the  last known mailing address of
     the party for whom the notice is intended.

24.  INSOLVENCY OR BANKRUPTCY.  If Lessee becomes insolvent; voluntarily
     or involuntarily bankrupt, or if a receiver or other liquidating
     officer is appointed for the business of Lessee which will
     constitute default herein, then Lessor may terminate this Lease.

25.  ESTOPPEL CERTIFICATE.  Lessee agrees to execute any such estoppel
     certificates as Lessor may, from time, to time, request detailing
     the status of Lessee's rental under this lease agreement

26.  ENTIRE AGREEMENT. It is understood and agreed by Lessor and Lessee
     that there are no promises, agreemeents, conditions, understandings,
     warranties oral or written, expressed or implied, between them,
     other than

                                                            Initial _____
                                                                    _____
                                    7
<PAGE>
     as herin set forth and that this Lease shall not be modified except
     in writing acknowledged by all parties.

IN WITNESS WHEREOF, Lessor and Lessee have executed this Lease on the day
and year first mentioned.

LESSOR:                            LESSES:

GREENERY EXECUTIVE SUITES          AMERIMMUNE PHARMACEUTICALS, INC.

BY:Sandy Abblett                   BY: Pamela M. Kapustay
-------------------------------    -------------------------------

TITLE: Office Manager              TITLE: V.P. of Operations
-------------------------------    -------------------------------

DATE:      1/30/02                 DATE:      1/30/02
-------------------------------    -------------------------------

                                                            Initial _____
                                                                    _____
                                    8
<PAGE>

                   [Blueprint sketch of office space]

                                    9

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00042-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00042-of-00352.parquet"}]]