Document:

EX-10.10

 Exhibit 10.10 

MEREO BIOPHARMA GROUP LIMITED 

FOURTH FLOOR 
 ONE CAVENDISH PLACE

 LONDON 
 W1G 0QF 

PRIVATE AND CONFIDENTIAL 
 Paul Blackburn 

[XXXXXX] 
 [XXXXXX] 

[XXXXXX] 
 28 October 2015 

Dear Paul, 
 Letter of appointment 

Following the resolution of the board of directors (Board) of Mereo BioPharma Group Limited (Company) on 6 October 2015 we are pleased to
hear that you have accepted our offer to join the Board as a non executive director. Your appointment formally commenced on 6 October 2015. 
 This
letter sets out the main terms of your appointment. By accepting this appointment, you agree that this letter is a contract for services and is not a contract of employment and you confirm that you are not subject to any restrictions which prevent
you from holding office as a director. 
  

	1.	FEES AND EXPENSES 

  

	1.1	You shall be paid an annual fee of £35,000 gross (current at the date of this letter), which shall be paid in equal instalments monthly in arrears through PAYE after deduction of any taxes and other amounts that
are required by law, which shall be subject to periodic review by the Board. This fee covers all duties, including service on any Board committee or Company subsidiary, with the exception of committee chairmanships and certain additional
responsibilities. 

  

	1.2	The Company shall reimburse you for all reasonable and properly documented expenses that you incur in performing the duties of your office including travel and sundry expenses. 

  
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	1.3	On termination of your appointment, you shall only be entitled to such fees as may have accrued to the date of termination, together with reimbursement in the normal way of any expenses properly incurred before that
date. 

  

	2.	ROLE AND DUTIES 

  

	2.1	The Board as a whole is collectively responsible for the success of the Company. The Board’s role is to: 

  

	 	(a)	provide entrepreneurial leadership of the Company within a framework of prudent and effective controls which enable risk to be assessed and managed; 

 

	 	(b)	set the Company’s strategic aims, ensure that the necessary financial and human resources are in place for the Company to meet its objectives, and review management performance; and 

 

	 	(c)	set the Company’s values and standards and ensure that its obligations to its shareholders and others are understood and met. 

  

	2.2	You shall have the same general legal responsibilities to the Company as any other director. You are expected to perform your duties (whether statutory, fiduciary or common law) faithfully, diligently and to a standard
commensurate with the functions of your role and your knowledge, skills and experience. 

  

	2.3	You shall exercise your powers in your role as a non-executive director having regard to relevant obligations under prevailing law and regulation, including the Companies Act 2006
and, where applicable, the UK Corporate Governance Code and associated guidance or the AIM Rules for Companies, the UK Listing Authority’s Listing, Prospectus, and Disclosure and Transparency Rules. 

 

	2.4	You shall have particular regard to the general duties of directors in Part 10 of the Companies Act 2006, including the duty to promote the success of the Company under which all directors must act in the way they
consider, in good faith, would be most likely to promote the success of the Company for the benefit of its members as a whole. In doing so, as a director, you must have regard (among other matters) to: 

 

	 	(a)	the likely consequences of any decision in the long term; 

  

	 	(b)	the interests of the Company’s employees; 

  

	 	(c)	the need to foster the Company’s business relationships with suppliers, customers and others; 

  

	 	(d)	the impact of the Company’s operations on the community and the environment; 

  

	 	(e)	the desirability of the Company maintaining a reputation for high standards of business conduct; and 

  

	 	(f)	the need to act fairly as between the members of the Company. 

  
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	2.5	If and when applicable, you shall have particular regard to the Financial Reporting Council’s UK Corporate Governance Code and associated Guidance on Board Effectiveness in respect of the role of the Board and the
role of the non-executive director. 

  

	2.6	In your role as a non-executive director, you shall also be required to: 

  

	 	(a)	constructively challenge and help develop proposals on strategy including, where applicable, the Company’s corporate development activity to secure additional products, the clinical development plans for the
current product portfolio and the financing and IPO strategy; 

  

	 	(b)	monitor the performance of senior management in meeting agreed goals and objectives and monitor the reporting of performance; 

  

	 	(c)	satisfy yourself on the integrity of financial information and that financial controls and systems of risk management are robust and defensible; 

 

	 	(d)	be responsible for determining appropriate levels of remuneration of executive directors and have a prime role in appointing and, where necessary, removing senior management and in succession planning;

  

	 	(e)	uphold high standards of integrity and probity and support the executive directors in instilling the appropriate culture, values and behaviours in the boardroom and beyond; 

 

	 	(f)	insist on receiving high-quality information sufficiently in advance of Board meetings; 

  

	 	(g)	take into account the views of shareholders and other stakeholders where appropriate; 

  

	 	(h)	make sufficient time available to discharge your responsibilities effectively; 

  

	 	(i)	exercise relevant powers under, and abide by, the Articles; 

  

	 	(j)	disclose the nature and extent of any direct or indirect interest you may have in any matter being considered at a Board or committee meeting and, except as permitted under the Articles you will not vote on any
resolution of the Board, or of one of its committees, on any matter where you have any direct or indirect interest; 

  

	 	(k)	immediately report your own wrongdoing or the wrongdoing or proposed wrongdoing of any employee or other director of the Company of which you become aware to the Chair of the Audit Committee.; 

 

	 	(l)	exercise your powers as a director in accordance with the Company’s policies and procedures and the Bribery Act 2010; and 

  

	 	(m)	not do anything that would cause you to be disqualified from acting as a director. 

  
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	2.7	Unless the Board specifically authorises you to do so, you shall not enter into any legal or other commitment or contract on behalf of the Company. 

 

	2.8	You shall be entitled to request all relevant information about the Company’s affairs as is reasonably necessary to enable you to discharge your duties as a non-executive
director. 

  

	2.9	If you are required to register yourself or your personal service company with HM Revenue and Customs as a “Trust or Company Service Provider” under the Money Laundering Regulations 2007, you will be
responsible for effecting such registration and for compliance with other requirements of the Money Laundering Regulations 2007 and applicable legislation. 

  

	3.	CONFIDENTIALITY 

  

	3.1	You acknowledge that all information acquired during your appointment is confidential to the Company and should not be released, communicated or disclosed to third parties or used for any reason other than in the
interests of the Company, either during your appointment or following termination (by whatever means), without prior clearance from the Chief Executive. This restriction shall cease to apply to any confidential information which may (other than by
reason of your breach) become available to the public generally. 

  

	3.2	You acknowledge the need to hold and retain Company information (in whatever format you may receive it) under appropriately secure conditions. 

 

	3.3	Nothing in this paragraph 3 shall prevent you from disclosing information which you are entitled to disclose under the Public Interest Disclosure Act 1998, provided that the disclosure is made in accordance with the
provisions of that Act and you have complied with the Company’s policy from time to time in force regarding such disclosures. 

  

	4.	TIME COMMITMENT 

  

	4.1	You will be expected to devote such time as is necessary for the proper performance of your duties. Overall we anticipate that you will spend a minimum of two days a month on work for the Company. This will include
attendance at six annual Board meetings, the AGM, one annual Board away day a year, meetings with the non-executive directors, meetings with shareholders, meetings forming part of the Board evaluation process
and updating and training meetings. Some of these meetings may involve overseas travel. In addition, you will be required to consider all relevant papers before each meeting. 

  
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	4.2	The nature of the role makes it impossible to be specific about the maximum time commitment. You may be required to devote additional time to the Company in respect of preparation time and ad hoc matters which may arise
and particularly when the Company is undergoing a period of increased activity. At certain times it may be necessary to convene additional Board, committee or shareholder meetings. 

 

	4.3	The overall time commitment stated in paragraph 4.1 will increase as you become a committee member and chair, or if you are given additional responsibilities such as being appointed a
non-executive director on the boards of any of the Company’s subsidiaries. Details of the expected increase in time commitment will be covered in any relevant communication confirming the additional
responsibility and any proposed changes in remuneration. 

  

	4.4	By accepting this appointment, you confirm that, taking into account all of your other commitments, you are able to allocate sufficient time to the Company to discharge your responsibilities effectively. You should
obtain the agreement of the Chief Executive or Chairman (who may determine that Board approval is required) before accepting additional commitments that might affect the time you are able to devote to your role as a
non-executive director of the Company. 

  

	5.	APPOINTMENT 

  

	5.1	Subject to the remaining provisions of this letter, your appointment shall be for an initial term commencing on 6 October 2015 until the conclusion of the Company’s annual general meeting (AGM)
occurring approximately three years from that date unless terminated earlier by either party giving to the other three months’ prior written notice. 

  

	5.2	Your appointment is subject to the Company’s articles of association, as amended from time to time (Articles). Nothing in this letter shall be taken to exclude or vary the terms of the Articles as they apply
to you as a director of the Company. 

  

	5.3	Continuation of your appointment is contingent on your continued satisfactory performance and re-election by the shareholders and any relevant statutory provisions relating to
removal of a director. If the shareholders do not re-elect you as a director, or you are retired from office under the Articles, your appointment shall terminate automatically, with immediate effect and
without compensation. 

  

	5.4	Non-executive directors are typically expected to serve two three-year terms but may be invited by the Board to serve for an additional period. Any term renewal is subject to
Board review and AGM re-election. Notwithstanding any mutual expectation, there is no right to re-nomination by the Board, either annually or after any three-year
period. 

  
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	5.5	You may be required to serve on one or more Board committees. You will be provided with the relevant terms of reference on your appointment to such a committee. You may be required to serve as a non-executive director on the board of any of the Company’s subsidiaries and will be provided with the relevant terms of reference on your appointment to such board(s). 

 

	5.6	Notwithstanding paragraph 5.1 to paragraph 5.5, the Company may terminate your appointment with immediate effect if you have: 

  

	 	(a)	committed a material breach of your obligations under this letter; 

  

	 	(b)	committed any serious or repeated breach or non-observance of your obligations to the Company (which include an obligation not to breach your statutory, fiduciary or common-law duties); 

  

	 	(c)	been guilty of any fraud or dishonesty or acted in any manner which, in the Company’s opinion, brings or is likely to bring you or the Company into disrepute or is materially adverse to the Company’s
interests; 

  

	 	(d)	been convicted of an arrestable criminal offence other than a road traffic offence for which a fine or non-custodial penalty is imposed; 

 

	 	(e)	been declared bankrupt or have made an arrangement with or for the benefit of your creditors, or if you have a county court administration order made against you under the County Court Act 1984; 

 

	 	(f)	been disqualified from acting as a director; or 

  

	 	(g)	not complied with the Company’s anti-corruption and bribery policy and procedures. 

  

	5.7	On termination of your appointment, you shall, at the Company’s request, resign from your office as non-executive director of the Company and any offices you hold in any of
the Company’s subsidiary companies. 

  

	5.8	If matters arise which cause you concern about your role, you should discuss these matters with the Chief Executive and Chairman. If you have any concerns which cannot be resolved, and you choose to resign for that, or
any other, reason, you should provide an appropriate written statement to the Chief Executive and Chairman for circulation to the Board. 

  

	6.	INDEPENDENT PROFESSIONAL ADVICE 

In some circumstances you may consider that you need professional advice in the furtherance of your duties as a
non-executive director and it may be appropriate for you to seek advice from independent advisers at the Company’s expense. A copy of the Board’s agreed procedure under which directors may obtain
such independent advice is available from the Company’s General Counsel. The Company shall reimburse the reasonable cost of expenditure incurred by you in accordance with its policy. 

  
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	7.	OUTSIDE INTERESTS 

  

	7.1	You have already disclosed to the Board the significant commitments you have outside your role in the Company. You must inform the Chairman or the Nomination Committee in advance of any changes to these commitments. In
certain circumstances, you may have to seek the Board’s agreement before accepting further commitments which either might give rise to a conflict of interest or a conflict with any of your duties to the Company, or which might impact on the
time that you are able to devote to your role at the Company. 

  

	7.2	It is accepted and acknowledged that you have business interests other than those of the Company and have declared any conflicts that are apparent at present. If you become aware of any further potential or actual
conflicts of interest, these should be disclosed to the Chairman as soon as you become aware of them and again you may have to seek the agreement of the Board. 

  

	8.	INSIDE INFORMATION AND DEALING IN THE COMPANY’S SHARES

  

	8.1	Your attention is drawn to the requirements under both law and regulation as to the disclosure of inside information, in particular to the Disclosure and Transparency Rules of the UK Listing Authority and section 52 of
the Criminal Justice Act 1993 on insider dealing. You should avoid making any statements that might risk a breach of these requirements. If in doubt, please contact the Chief Executive or General Counsel. 

 

	8.2	During your period of appointment you are required to comply, where applicable, with the Model Code (as annexed to the Listing Rules of the UK Listing Authority) or AIM Rules for Companies in relation to dealing in the
Company’s publicly traded or quoted securities, and any other code as the Company may adopt from time to time which sets out the terms for dealings by directors in the Company’s securities. A copy of the current share dealing code adopted
by the Company will be provided to you separately. 

  

	9.	TRAINING 

 On an ongoing basis, and further to the annual
evaluation process, the Company will arrange for you to develop and refresh your skills and knowledge in areas which are mutually identified as being likely to be required, or of benefit to you, in carrying out your duties effectively. You should
try to make yourself available for any relevant training sessions which may be organised for the Board. 
  

	10.	REVIEW PROCESS 

 The performance of
individual directors and the whole Board and its committees is evaluated annually. If, in the interim, there are any matters which cause you concern about your role you should discuss them with the Chief Executive or the Nomination Committee as soon
as you can. 

  
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	11.	INSURANCE AND INDEMNITY 

  

	11.1	The Company has directors’ and officers’ liability insurance and it intends to maintain such cover for the full term of your appointment. The indemnity limit is £10 million (current at the date of
this letter). A copy of the policy document is available from the Company’s General Counsel. 

  

	11.2	The Company shall grant you a deed of indemnity against certain liabilities that may be incurred as a result of your office to the extent permitted by section 234 of the Companies Act 2006. 

 

	12.	CHANGES TO PERSONAL DETAILS 

You shall advise the General Counsel promptly of any change in your address or other personal contact details. 

 

	13.	RETURN OF PROPERTY 

 On
termination of your appointment with the Company however arising, or at any time at the Board’s request, you shall immediately return to the Company any property of the Company in your possession or under your control including any electrical
or electronic equipment and any security pass and keys and deliver to the Company all documents, records, papers (in electronic or hard copy form) or other property belonging to the Company or any company in the Company’s group which may be in
your possession or under your control, and which relate in any way to the Company’s or a group company’s business affairs and you shall not retain any copies thereof. If you have any information relating to the Company or work carried out
for the Company which is stored on a computer that does not belong to the Company, this must be disclosed to the Company and the Company shall be entitled to download the information or work and/or supervise its deletion from the computer concerned.

  

	14.	MORAL RIGHTS 

 You hereby irrevocably waive
any moral rights in all works prepared by you, in the provision of your services to the Company, to which you are now or may at any future time be entitled under Chapter IV of the Copyright Designs and Patents Act 1988 or any similar provisions of
law in any jurisdiction, including (but without limitation) the right to be identified, the right of integrity and the right against false attribution, and agree not to institute, support, maintain or permit any action or claim to the effect that
any treatment, exploitation or use of such works or other materials, infringes your moral rights. 

  
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	15.	DATA PROTECTION 

  

	15.1	By signing this letter you consent to the Company holding and processing data about you for legal, personnel, administrative and management purposes and in particular to the processing of any sensitive personal
data (as defined in the Data Protection Act 1998) relating to you including, as appropriate: 

  

	 	(a)	information about your physical or mental health or condition in order to monitor sick leave and take decisions as to your fitness to perform your duties; or 

 

	 	(b)	your racial or ethnic origin or religious or similar beliefs in order to monitor compliance with equal opportunities legislation; or 

 

	 	(c)	information relating to any criminal proceedings in which you have been involved for insurance purposes and in order to comply with legal requirements and obligations to third parties. 

 

	15.2	You consent to the Company making such information available to any of its group companies, those who provide products or services to the Company or any company in the Company’s group (such as advisers and payroll
administrators), regulatory authorities, potential or future employers, governmental or quasi-governmental organisations and potential purchasers of the Company or the business in which you work. 

 

	15.3	You also consent to the transfer of such information to the Company’s or any group company’s business contacts outside the European Economic Area in order to further their business interests even where the
country or territory in question does not maintain adequate data protection standards. 

  

	15.4	You shall comply with the Company’s data protection policy, a copy of which is available from the Company’s General Counsel. 

 

	15.5	The Company may change its data protection policy at any time and will notify you in writing of any changes. 

  

	16.	THIRD PARTY RIGHTS 

 No one
other than you and the Company shall have any rights to enforce the terms of this letter. 

  
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	17.	ENTIRE AGREEMENT 

  

	17.1	This letter and any document referred to in it constitutes the entire terms and conditions of your appointment and supersedes and extinguishes all previous agreements, promises, assurances, warranties, representations
and understandings between you and the Company, whether written or oral, relating to its subject matter. 

  

	17.2	You agree that you shall have no remedies in respect of any representation, assurance or warranty (whether made innocently or negligently) that is not set out in this letter and you shall not have any claim for innocent
or negligent misrepresentation based on any statement in this letter. 

  

	18.	VARIATION 

 No variation of this letter shall be effective
unless it is in writing and signed by you and the Company (or respective authorised representatives). 
  

	19.	GOVERNING LAW AND JURISDICTION 

Your appointment with the Company and any dispute or claim arising out of or in connection with it or its subject matter or formation
(including non-contractual disputes or claims) shall be governed by and construed in accordance with the law of England and Wales and you and the Company irrevocably agree that the courts of England and Wales
shall have exclusive jurisdiction to settle any dispute or claim that arises out of or in connection with this appointment or its subject matter or formation (including non-contractual disputes or claims).

 Please indicate your acceptance of these terms by signing and returning to the attached copy of this letter to Denise Scots-Knight, Chief Executive,
Mereo BioPharma Group Limited. 
 Yours sincerely 
 /s/
Denise Scots-Knight                             

For and on behalf of Mereo BioPharma Group Limited 
 I
agree to the above terms of my appointment as a non-executive director of Mereo BioPharma Group Limited as set out in this letter. 

Signed on 26 October 2015 
 /s/ Paul
Blackburn                                     

Paul Blackburn 

  
 10EX-10.11

 Exhibit 10.11 

MEREO BIOPHARMA GROUP LIMITED 
 15
STRATTON STREET 
 LONDON W1J 8LQ 
 PRIVATE
AND CONFIDENTIAL 
 Anders Ekblom 
 [XXXXXX] 

[XXXXXX] 
 29 July 2015 

Dear Anders, 
 Letter of appointment 

Following the recommendation of the nomination committee, the board of directors (Board) of Mereo BioPharma Group Limited (Company) is pleased
to hear that you have accepted our offer to join the Board as a non executive director. Your appointment will formally commence on the date of closing of the financing the Company. 

This letter sets out the main terms of your appointment. By accepting this appointment, you agree that this letter is a contract for services and is not a
contract of employment and you confirm that you are not subject to any restrictions which prevent you from holding office as a director. 
  

	1.	FEES AND EXPENSES 

  

	1.1	You shall be paid an annual fee of £35,000 gross (current at the date of this letter), which shall be paid in equal instalments monthly in arrears through PAYE after deduction of any taxes and other amounts that
are required by law, which shall be subject to periodic review by the Board. This fee covers all duties, including service on any Board committee or Company subsidiary, with the exception of committee chairmanships and certain additional
responsibilities, such as taking on the role of senior independent director. 

  

	1.2	The Company will reserve sufficient ordinary shares following issuance of the Company’s ordinary shares (the Option Pool) of which you shall be entitled to 81,284 shares pursuant to the terms of the
Company’s proposed equity incentive plan. 

	1.3	The Company shall reimburse you for all reasonable and properly documented expenses that you incur in performing the duties of your office including travel and sundry expenses. 

 

	1.4	On termination of your appointment, you shall only be entitled to such fees as may have accrued to the date of termination, together with reimbursement in the normal way of any expenses properly incurred before that
date. 

  

	2.	ROLE AND DUTIES 

  

	2.1	The Board as a whole is collectively responsible for the success of the Company. The Board’s role is to: 

  

	 	(a)	provide entrepreneurial leadership of the Company within a framework of prudent and effective controls which enable risk to be assessed and managed; 

 

	 	(b)	set the Company’s strategic aims, ensure that the necessary financial and human resources are in place for the Company to meet its objectives, and review management performance; and 

 

	 	(c)	set the Company’s values and standards and ensure that its obligations to its shareholders and others are understood and met. 

  

	2.2	You shall have the same general legal responsibilities to the Company as any other director. You are expected to perform your duties (whether statutory, fiduciary or common law) faithfully, diligently and to a standard
commensurate with the functions of your role and your knowledge, skills and experience. 

  

	2.3	You shall exercise your powers in your role as a non-executive director having regard to relevant obligations under prevailing law and regulation, including the Companies Act 2006
and, where applicable, the UK Corporate Governance Code and associated guidance or the AIM Rules for Companies, the UK Listing Authority’s Listing, Prospectus, and Disclosure and Transparency Rules. 

 

	2.4	You shall have particular regard to the general duties of directors in Part 10 of the Companies Act 2006, including the duty to promote the success of the Company under which all directors must act in the way they
consider, in good faith, would be most likely to promote the success of the Company for the benefit of its members as a whole. In doing so, as a director, you must have regard (among other matters) to: 

 

	 	(a)	the likely consequences of any decision in the long term; 

  

	 	(b)	the interests of the Company’s employees; 

  

	 	(c)	the need to foster the Company’s business relationships with suppliers, customers and others; 

  

	 	(d)	the impact of the Company’s operations on the community and the environment; 

  
 2 

	 	(e)	the desirability of the Company maintaining a reputation for high standards of business conduct; and 

  

	 	(f)	the need to act fairly as between the members of the Company. 

  

	2.5	If and when applicable, you shall have particular regard to the Financial Reporting Council’s UK Corporate Governance Code and associated Guidance on Board Effectiveness in respect of the role of the Board and the
role of the non-executive director. 

  

	2.6	In your role as a non-executive director, you shall also be required to: 

  

	 	(a)	constructively challenge and help develop proposals on strategy including, where applicable, the Company’s corporate development activity to secure additional products, the clinical development plans for the
current product portfolio and the financing and IPO strategy; 

  

	 	(b)	monitor the performance of senior management in meeting agreed goals and objectives and monitor the reporting of performance; 

  

	 	(c)	satisfy yourself on the integrity of financial information and that financial controls and systems of risk management are robust and defensible; 

 

	 	(d)	be responsible for determining appropriate levels of remuneration of executive directors and have a prime role in appointing and, where necessary, removing senior management and in succession planning;

  

	 	(e)	uphold high standards of integrity and probity and support the executive directors in instilling the appropriate culture, values and behaviours in the boardroom and beyond; 

 

	 	(f)	insist on receiving high-quality information sufficiently in advance of Board meetings; 

  

	 	(g)	take into account the views of shareholders and other stakeholders where appropriate; 

  

	 	(h)	make sufficient time available to discharge your responsibilities effectively; 

  

	 	(i)	exercise relevant powers under, and abide by, the Articles; 

  

	 	(j)	disclose the nature and extent of any direct or indirect interest you may have in any matter being considered at a Board or committee meeting and, except as permitted under the Articles you will not vote on any
resolution of the Board, or of one of its committees, on any matter where you have any direct or indirect interest; 

  

	 	(k)	immediately report your own wrongdoing or the wrongdoing or proposed wrongdoing of any employee or other director of the Company of which you become aware to the Chair of the Audit Committee.; 

 

	 	(l)	exercise your powers as a director in accordance with the Company’s policies and procedures and the Bribery Act 2010; and 

  
 3 

	 	(m)	not do anything that would cause you to be disqualified from acting as a director. 

  

	2.7	Unless the Board specifically authorises you to do so, you shall not enter into any legal or other commitment or contract on behalf of the Company. 

 

	2.8	You shall be entitled to request all relevant information about the Company’s affairs as is reasonably necessary to enable you to discharge your duties as a non-executive
director. 

  

	2.9	If you are required to register yourself or your personal service company with HM Revenue and Customs as a “Trust or Company Service Provider” under the Money Laundering Regulations 2007, you will be
responsible for effecting such registration and for compliance with other requirements of the Money Laundering Regulations 2007 and applicable legislation. 

  

	3.	CONFIDENTIALITY 

  

	3.1	You acknowledge that all information acquired during your appointment is confidential to the Company and should not be released, communicated or disclosed to third parties or used for any reason other than in the
interests of the Company, either during your appointment or following termination (by whatever means), without prior clearance from the Chief Executive. This restriction shall cease to apply to any confidential information which may (other than by
reason of your breach) become available to the public generally. 

  

	3.2	You acknowledge the need to hold and retain Company information (in whatever format you may receive it) under appropriately secure conditions. 

 

	3.3	Nothing in this paragraph 3 shall prevent you from disclosing information which you are entitled to disclose under the Public Interest Disclosure Act 1998, provided that the disclosure is made in accordance with the
provisions of that Act and you have complied with the Company’s policy from time to time in force regarding such disclosures. 

  

	4.	TIME COMMITMENT 

  

	4.1	 You will be expected to devote such time as is necessary for the proper performance of your duties. Overall we
anticipate that you will spend a minimum of two days a month on work for the Company. This will include attendance at six annual Board meetings, the AGM, one annual Board away day a year, meetings with the
non-executive directors, meetings with shareholders, meetings forming part of the Board evaluation process and updating and training meetings. Some of these meetings may involve overseas travel. In addition,
you will be required to consider all relevant papers before each meeting. You will be provided with a schedule and proposed location of the first six annual board meetings at the date of completion of the

  
 4 

	 	
Company’s initial financing round and for subsequent board meetings at least six months in advance of each board meeting. Unless urgent and unavoidable circumstances prevent you from doing
so, it is expected that you will attend the meetings outlined in this paragraph. 

  

	4.2	The nature of the role makes it impossible to be specific about the maximum time commitment. You may be required to devote additional time to the Company in respect of preparation time and ad hoc matters which may arise
and particularly when the Company is undergoing a period of increased activity. At certain times it may be necessary to convene additional Board, committee or shareholder meetings. 

 

	4.3	The overall time commitment stated in paragraph 4.1 will increase if you become a committee member or chair, or if you are given additional responsibilities such as being appointed the senior independent director, or non-executive director on the boards of any of the Company’s subsidiaries. Details of the expected increase in time commitment will be covered in any relevant communication confirming the additional
responsibility and any proposed changes in remuneration. 

  

	4.4	By accepting this appointment, you confirm that, taking into account all of your other commitments, you are able to allocate sufficient time to the Company to discharge your responsibilities effectively. You should
obtain the agreement of the Chief Executive or Chairman (who may determine that Board approval is required) before accepting additional commitments that might affect the time you are able to devote to your role as a
non-executive director of the Company. 

  

	5.	APPOINTMENT 

  

	5.1	Subject to the remaining provisions of this letter, your appointment shall be for an initial term of three years commencing on the date of completion of the Company’s initial financing until the conclusion of the
Company’s annual general meeting (AGM) occurring approximately three years from that date unless terminated earlier by either party giving to the other three months’ prior written notice. 

 

	5.2	Your appointment is subject to the Company’s articles of association, as amended from time to time (Articles). Nothing in this letter shall be taken to exclude or vary the terms of the Articles as they apply
to you as a director of the Company. 

  

	5.3	Continuation of your appointment is contingent on your continued satisfactory performance and re-election by the shareholders and any relevant statutory provisions relating to
removal of a director. If the shareholders do not re-elect you as a director, or you are retired from office under the Articles, your appointment shall terminate automatically, with immediate effect and
without compensation. 

  
 5 

	5.4	Non-executive directors are typically expected to serve two three-year terms but may be invited by the Board to serve for an additional period. Any term renewal is subject to
Board review and AGM re-election. Notwithstanding any mutual expectation, there is no right to re-nomination by the Board, either annually or after any three-year
period. 

  

	5.5	You may be required to serve on one or more Board committees. You will be provided with the relevant terms of reference on your appointment to such a committee. You may be required to serve as a non-executive director on the board of any of the Company’s subsidiaries and will be provided with the relevant terms of reference on your appointment to such board(s). 

 

	5.6	Notwithstanding paragraph 5.1 to paragraph 5.5, the Company may terminate your appointment with immediate effect if you have: 

  

	 	(a)	committed a material breach of your obligations under this letter; 

  

	 	(b)	committed any serious or repeated breach or non-observance of your obligations to the Company (which include an obligation not to breach your statutory, fiduciary or common-law duties); 

  

	 	(c)	been guilty of any fraud or dishonesty or acted in any manner which, in the Company’s opinion, brings or is likely to bring you or the Company into disrepute or is materially adverse to the Company’s
interests; 

  

	 	(d)	been convicted of an arrestable criminal offence other than a road traffic offence for which a fine or non-custodial penalty is imposed; 

 

	 	(e)	been declared bankrupt or have made an arrangement with or for the benefit of your creditors, or if you have a county court administration order made against you under the County Court Act 1984; 

 

	 	(f)	been disqualified from acting as a director; or 

  

	 	(g)	not complied with the Company’s anti-corruption and bribery policy and procedures. 

  

	5.7	On termination of your appointment, you shall, at the Company’s request, resign from your office as non-executive director of the Company and any offices you hold in any of
the Company’s subsidiary companies. 

  

	5.8	If matters arise which cause you concern about your role, you should discuss these matters with the Chief Executive and Chairman. If you have any concerns which cannot be resolved, and you choose to resign for that, or
any other, reason, you should provide an appropriate written statement to the Chief Executive and Chairman for circulation to the Board. 

  
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	6.	INDEPENDENT PROFESSIONAL ADVICE 

 In some
circumstances you may consider that you need professional advice in the furtherance of your duties as a non-executive director and it may be appropriate for you to seek advice from independent advisers at the
Company’s expense. A copy of the Board’s agreed procedure under which directors may obtain such independent advice is available from the Company’s General Counsel. The Company shall reimburse the reasonable cost of expenditure
incurred by you in accordance with its policy. 
  

	7.	OUTSIDE INTERESTS 

  

	7.1	You have already disclosed to the Board the significant commitments you have outside your role in the Company. You must inform the Chairman or the Nomination Committee in advance of any changes to these commitments. In
certain circumstances, you may have to seek the Board’s agreement before accepting further commitments which either might give rise to a conflict of interest or a conflict with any of your duties to the Company, or which might impact on the
time that you are able to devote to your role at the Company. 

  

	7.2	It is accepted and acknowledged that you have business interests other than those of the Company and have declared any conflicts that are apparent at present. If you become aware of any further potential or actual
conflicts of interest, these should be disclosed to the Chairman as soon as you become aware of them and again you may have to seek the agreement of the Board. 

  

	8.	INSIDE INFORMATION AND DEALING IN THE COMPANY’S SHARES

  

	8.1	Your attention is drawn to the requirements under both law and regulation as to the disclosure of inside information, in particular to the Disclosure and Transparency Rules of the UK Listing Authority and section 52 of
the Criminal Justice Act 1993 on insider dealing. You should avoid making any statements that might risk a breach of these requirements. If in doubt, please contact the Chief Executive or General Counsel. 

 

	8.2	During your period of appointment you are required to comply, where applicable, with the Model Code (as annexed to the Listing Rules of the UK Listing Authority) or AIM Rules for Companies in relation to dealing in the
Company’s publicly traded or quoted securities, and any other code as the Company may adopt from time to time which sets out the terms for dealings by directors in the Company’s securities. A copy of the current share dealing code adopted
by the Company will be provided to you separately. 

  
 7 

	9.	TRAINING 

 On an ongoing basis, and further to the annual evaluation
process, the Company will arrange for you to develop and refresh your skills and knowledge in areas which are mutually identified as being likely to be required, or of benefit to you, in carrying out your duties effectively. You should try to make
yourself available for any relevant training sessions which may be organised for the Board. 
  

	10.	REVIEW PROCESS 

 The performance of individual directors
and the whole Board and its committees is evaluated annually. If, in the interim, there are any matters which cause you concern about your role you should discuss them with the Chief Executive or the Nomination Committee as soon as you can. 

 

	11.	INSURANCE AND INDEMNITY 

  

	11.1	The Company has directors’ and officers’ liability insurance and it intends to maintain such cover for the full term of your appointment. The indemnity limit is £10 million (current at the date of
this letter). A copy of the policy document is available from the Company’s General Counsel. 

  

	11.2	The Company shall grant you a deed of indemnity against certain liabilities that may be incurred as a result of your office to the extent permitted by section 234 of the Companies Act 2006. 

 

	12.	CHANGES TO PERSONAL DETAILS 

You shall advise the General Counsel promptly of any change in your address or other personal contact details. 

 

	13.	RETURN OF PROPERTY 

 On termination of your
appointment with the Company however arising, or at any time at the Board’s request, you shall immediately return to the Company any property of the Company in your possession or under your control including any electrical or electronic
equipment and any security pass and keys and deliver to the Company all documents, records, papers (in electronic or hard copy form) or other property belonging to the Company or any company in the Company’s group which may be in your
possession or under your control, and which relate in any way to the Company’s or a group company’s business affairs and you shall not retain any copies thereof. If you have any information relating to the Company or work carried out for
the Company which is stored on a computer that does not belong to the Company, this must be disclosed to the Company and the Company shall be entitled to download the information or work and/or supervise its deletion from the computer concerned.

  
 8 

	14.	MORAL RIGHTS 

 You hereby irrevocably waive any moral
rights in all works prepared by you, in the provision of your services to the Company, to which you are now or may at any future time be entitled under Chapter IV of the Copyright Designs and Patents Act 1988 or any similar provisions of law in any
jurisdiction, including (but without limitation) the right to be identified, the right of integrity and the right against false attribution, and agree not to institute, support, maintain or permit any action or claim to the effect that any
treatment, exploitation or use of such works or other materials, infringes your moral rights. 
  

	15.	DATA PROTECTION 

  

	15.1	By signing this letter you consent to the Company holding and processing data about you for legal, personnel, administrative and management purposes and in particular to the processing of any sensitive personal
data (as defined in the Data Protection Act 1998) relating to you including, as appropriate: 

  

	 	(a)	information about your physical or mental health or condition in order to monitor sick leave and take decisions as to your fitness to perform your duties; or 

 

	 	(b)	your racial or ethnic origin or religious or similar beliefs in order to monitor compliance with equal opportunities legislation; or 

 

	 	(c)	information relating to any criminal proceedings in which you have been involved for insurance purposes and in order to comply with legal requirements and obligations to third parties. 

 

	15.2	You consent to the Company making such information available to any of its group companies, those who provide products or services to the Company or any company in the Company’s group (such as advisers and payroll
administrators), regulatory authorities, potential or future employers, governmental or quasi-governmental organisations and potential purchasers of the Company or the business in which you work. 

 

	15.3	You also consent to the transfer of such information to the Company’s or any group company’s business contacts outside the European Economic Area in order to further their business interests even where the
country or territory in question does not maintain adequate data protection standards. 

  

	15.4	You shall comply with the Company’s data protection policy, a copy of which is available from the Company’s General Counsel. 

  
 9 

	15.5	The Company may change its data protection policy at any time and will notify you in writing of any changes. 

  

	16.	THIRD PARTY RIGHTS 

 No one other than you
and the Company shall have any rights to enforce the terms of this letter. 
  

	17.	ENTIRE AGREEMENT 

  

	17.1	This letter and any document referred to in it constitutes the entire terms and conditions of your appointment and supersedes and extinguishes all previous agreements, promises, assurances, warranties, representations
and understandings between you and the Company, whether written or oral, relating to its subject matter. 

  

	17.2	You agree that you shall have no remedies in respect of any representation, , assurance or warranty (whether made innocently or negligently) that is not set out in this letter and you shall not have any claim for
innocent or negligent misrepresentation based on any statement in this letter. 

  

	18.	VARIATION 

 No variation of this letter shall be effective unless it is in
writing and signed by you and the Company (or respective authorised representatives). 
  

	19.	GOVERNING LAW AND JURISDICTION 

Your appointment with the Company and any dispute or claim arising out of or in connection with it or its subject matter or formation
(including non-contractual disputes or claims) shall be governed by and construed in accordance with the law of England and Wales and you and the Company irrevocably agree that the courts of England and Wales
shall have exclusive jurisdiction to settle any dispute or claim that arises out of or in connection with this appointment or its subject matter or formation (including non-contractual disputes or claims).

  
 10 

 Please indicate your acceptance of these terms by signing and returning to the attached copy of this letter to
Denise Pollard-Knight, Chief Executive, Mereo BioPharma Group Limited. 
  

			
	Yours sincerely
		
		 	 /s/ Denise Pollard-Knight

 For and on behalf of Mereo BioPharma Group Limited 

I agree to the above terms of my appointment as a non-executive director of Mereo BioPharma Group Limited as set out
in this letter. 
  

			
	Signed on 20th July 2015
		
		 	 /s/ Anders Ekblom

 Anders Ekblom 

  
 11

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