Document:

Second Amended and Restated Employment Agreement

 Exhibit 10.4 
 SECOND AMENDED AND RESTATED EMPLOYMENT AGREEMENT 
 THIS SECOND
AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of December 18, 2008, by and between
WILLIAM D. YOUNG (the “Executive”) and MONOGRAM BIOSCIENCES, INC. (formerly VIROLOGIC,
INC.,), a Delaware corporation (the “Company”). 
 WHEREAS, Executive and the Company are parties to an Amended and Restated Employment Agreement dated September 20, 2007 (the “Prior Agreement”); and 
 WHEREAS, Executive and the Company desire to amend and restate the Prior Agreement and accept the rights and
covenants hereof in lieu of their rights and covenants under the Prior Agreement. 
 NOW,
THEREFORE, in consideration of these premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 
 1. DUTIES AND SCOPE OF EMPLOYMENT. 
 (a) Position. For the term of his employment under this Agreement (“Employment”), the Company agrees to employ the
Executive in the position of Chairman and Chief Executive Officer. The Executive shall report to the Company’s Board of Directors (the “Board”). 
 (b) Obligations to the Company. During the term of his Employment, the Executive shall devote his full business efforts and time to the Company; provided, however, that this shall not preclude the
Executive from serving as a non-executive member of the board of directors of up to three other companies to the extent such other companies do not compete with the Company and that such service does not materially impact the ability of the
Executive to fulfill his obligations to the Company. The Executive shall comply with the Company’s policies and rules, as they may be in effect from time to time during the term of his Employment. 
 (c) No Conflicting Obligations. The Executive represents and warrants to the Company that he is under no obligations or commitments,
whether contractual or otherwise, that are inconsistent with his obligations under this Agreement. The Executive represents and warrants that he will not use or disclose, in connection with his employment by the Company, any trade secrets or other
proprietary information or intellectual property in which the Executive or any other person has any right, title or interest and that his employment by the Company as contemplated by this Agreement will not infringe or violate the rights of any
other person or entity. The Executive represents and warrants to the Company that he has returned all property and confidential information belonging to any prior employers. 
 2. CASH AND INCENTIVE COMPENSATION. 
 (a) Salary. Commencing January 5, 2009, the Company shall pay the Executive as compensation for his services a base salary at a gross annual rate of $449,100, payable in accordance with the Company’s standard payroll
schedule. (The compensation specified in this Subsection (a), together with any increases in such compensation that the Company may grant from time to time, is referred to in this Agreement as “Base Compensation”.)

  

 1. 

 (b) Incentive Bonuses. The Executive shall be eligible to be considered for an annual
incentive bonus as part of the Company’s bonus program based on objective or subjective criteria established by the Board after consultation with Executive. Such bonus shall be contingent upon Executive’s continued employment through the
end of the bonus period and Executive shall have no right to any pro rata portion of the bonus. The determinations of the Board with respect to such bonus shall be final and binding. 
 3. VACATION AND EXECUTIVE BENEFITS. During the term of his Employment, the Executive shall be eligible for paid vacations in
accordance with the Company’s standard policy for similarly situated employees, as it may be amended from time to time. During the term of his Employment, the Executive shall be eligible to participate in any employee benefit plans maintained
by the Company for similarly situated employees, subject in each case to the generally applicable terms and conditions of the plan in question and to the determinations of any person or committee administering such plan. 
 4. BUSINESS EXPENSES. During the term of his Employment, the Executive shall be authorized to incur necessary
and reasonable travel, entertainment and other business expenses in connection with his duties hereunder. The Company shall reimburse the Executive for such expenses upon presentation of an itemized account and appropriate supporting documentation,
all in accordance with the Company’s generally applicable policies. 
 5. TERM OF EMPLOYMENT.

 (a) Basic Rule. Executive will remain employed with the Company until the date when the Executive’s Employment
terminates pursuant to Subsection (b) below. The Executive’s Employment with the Company shall be “at will,” and either the Executive or the Company may terminate the Executive’s Employment at any time, for any reason, with
or without Cause. Any contrary representations, which may have been made to the Executive shall be superseded by this Agreement. This Agreement shall constitute the full and complete agreement between the Executive and the Company on the “at
will” nature of the Executive’s Employment, which may only be changed in an express written agreement signed by the Executive and a duly authorized officer of the Company. 
 (b) Termination. The Company may terminate the Executive’s Employment at any time and for any reason (or no reason), and with or
without Cause, by giving the Executive notice in writing. The Executive may terminate his Employment by giving the Company 14 days’ advance notice in writing. The Executive’s Employment shall terminate automatically in the event of his
death or permanent disability. 
 (c) Rights Upon Termination. Except as expressly provided in Section 6, upon the
termination of the Executive’s Employment pursuant to this Section 5, the Executive shall only be entitled to the compensation, benefits and reimbursements described in Sections 2, 3 and 4 for the period preceding the effective date of the
termination. The payments under this Agreement shall fully discharge all responsibilities of the Company to the Executive. 
  

 2. 

 (d) Termination of Agreement. This Agreement shall terminate when all obligations of the
parties hereunder have been satisfied. The termination of this Agreement shall not limit or otherwise affect any of the Executive’s obligations under Section 7. 
 6. TERMINATION BENEFITS. 
 (a) Severance Pay. If the
Company terminates the Executive’s Employment for any reason other than for Cause, or if Employment is terminated by the death or permanent disability of the Executive, in either case whether such termination occurs prior or subsequent to a
Change in Control, then the Company shall: 
 (i) pay the Executive the greater of (a) $499,000 (the
“Fixed Amount”) or (b) his Base Compensation, over a period of twelve (12) months following the termination of his Employment (the “Continuation Period”), which amount shall be paid in
accordance with the Company’s standard payroll procedures; and 
 (ii) if the Executive elects to continue his
health insurance coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”) following the termination of his Employment, then the Company shall pay the Executive’s monthly premium under COBRA until the
earliest of (i) the close of the Continuation Period or (ii) the expiration of the Executive’s continuation coverage under COBRA. 
 (b) Covered Termination Benefits. In the event of a Covered Termination, Executive shall receive a severance payment equal to (i) one times the greater of (x) the Fixed Amount or (y) his Base Compensation, plus
(ii) the amount of the target bonus established for the Executive for the last completed fiscal year immediately preceding the Covered Termination. Such amount shall be subject to all required tax withholding and shall be paid in a lump sum
upon the later of (a) Executive’s compliance with subsection (c) below or (b) the effective date of the related Change in Control. 
 (c) General Release. Any other provision of this Agreement notwithstanding, subsections (a) and (b) above shall only apply if the Executive (i) has executed a general release (in the form
attached hereto as Exhibit A) of all known and unknown claims that he may then have against the Company or persons affiliated with the Company, and such general release has become effective no later than forty-five (45) days after the date on
which Executive’s Employment was terminated, and (ii) has agreed not to prosecute any legal action or other proceeding based upon any of such claims. 
 (d) Definitions 
 (i) “Cause.” For all purposes under
this Agreement, “Cause” shall mean: 
 (1) Unauthorized use or intentional disclosure of the confidential
information or trade secrets of the Company; 
 (2) Any material breach of this Agreement or the Employee Proprietary
Information Agreement between the Executive and the Company; 
  

 3. 

 (3) Conviction of, or a plea of “guilty” or “no contest” to, a
felony under the laws of the United States or any state thereof; 
 (4) Misappropriation of the assets of the Company
or other acts of dishonesty; 
 (5) Engagement in substance abuse which substantially impairs Executive’s ability
to perform the duties and obligations of Executive’s employment or causes material harm to the reputation of the Company; 
 (6) Personal engagement in any act of moral turpitude that causes material harm to the reputation of the Company; 
 (7) Commencement of employment with another employer while Executive is an employee of the Company without the prior consent of the Board of Directors; or 
 (8) Material misconduct or gross negligence in the performance of duties assigned to the Executive under this Agreement.

 (ii) “Change in Control.” For all purposes under this Agreement, “Change in
Control” shall mean: 
 (1) a sale or other disposition of all or substantially all of the assets of the Company;

 (2) a merger or consolidation in which the Company is not the surviving entity and in which the stockholders of the
Company immediately prior to such consolidation or merger own less than fifty percent (50%) of the surviving entity’s voting power immediately after the transaction; 
 (3) a reverse merger in which the Company is the surviving entity but the shares of Common Stock outstanding immediately preceding
the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise, and in which the stockholders of the Company immediately prior to such reverse merger own less than fifty percent
(50%) of the Company’s voting power immediately after the transaction; 
 (4) an acquisition by any person,
entity or group within the meaning of Section 13(d) or 14(d) of the Exchange Act, or any comparable successor provisions (excluding any employee benefit plan, or related trust, sponsored or maintained by the Company or subsidiary of the Company
or other entity controlled by the Company) of the beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act, or comparable successor rule) of securities of the Company representing at least fifty percent (50%) of
the voting power entitled to vote in the election of Directors; or 
 (5) in the event that the individuals who, as of
the date of this Agreement, are members of the Company’s Board (the “Incumbent Board”), cease for any reason to constitute at least fifty percent (50%) of the Board. (If the election, or nomination for election by
the Company’s stockholders, of any new Director is approved by a vote of at least fifty percent (50%) of the Incumbent Board, such new Director shall be considered to be a member of the Incumbent Board in the future.). 
  

 4. 

 (iii) “Constructive Termination.” For all purposes under
this Agreement, “Constructive Termination” shall mean the occurrence of any of the following events without the Executive’s express written consent: 
 (1) a change in Executive’s responsibilities which represents material adverse change from the Executive’s
responsibilities as in effect at any time within ninety (90) days preceding the effective date of a Change in Control or at any time thereafter, or the assignment to Executive of any duties or responsibilities which are materially and adversely
inconsistent with the Executive’s duties and responsibilities in effect at any time within ninety (90) days preceding the effective date of a Change in Control or at any time thereafter; 
 (2) a material reduction by the Company in Executive’s overall compensation package or any failure to pay Executive any
compensation or benefits to which Executive is entitled within fifteen (15) days of the date due; 
 (3) the
Company’s relocation of Executive to any place outside a fifty (50) mile radius of the Executive’s current worksite, except for reasonably required travel on the business of the Company and/or its affiliates which is not materially
greater than such travel requirements prior to the effective date of the Change in Control; 
 (4) the failure by the
Company to: (i) continue in effect (without reduction in benefit level and/or reward opportunities) any material compensation or employee benefit plan in which the Executive was participating at any time within ninety (90) days preceding
the effective date of a Change in Control or at any time thereafter, unless such plan is replaced with a plan that provides substantially equivalent compensation or benefits to Executive (it being understood that changes to any such plans
necessitated by the need to conform Executive’s and the Company’s other employees’, as a whole, compensation and benefits packages to those of the surviving corporation and/or acquiror (as applicable) shall not alone constitute
Constructive Termination unless such changes result in a material reduction in Executive’s overall annual compensation package as described in subsection (2) above), or (ii) provide Executive with compensation and benefits, in the
aggregate, at least substantially similar (in terms of benefit levels and/or reward opportunities) to those provided for under each other employee benefit plan, program and practice in which the Executive was participating at any time within ninety
(90) days preceding the effective date of a Change in Control or at any time thereafter; 
 (5) a material breach
by the Company of any provision of this Agreement, unless such breach is cured within fifteen (15) days following notice by the Executive of such breach; or 
 (6) any failure by the Company to obtain the assumption of this Agreement by the surviving corporation and/or acquiror (as
applicable) of the Company. 
  

 5. 

 (iv) “Covered Termination” means Executive terminates his
Employment within ninety (90) days following any Constructive Termination that occurs within three (3) months prior to or twenty-four (24) months following the effective date of a Change in Control. 
 (e) Mitigation. Except as otherwise specifically provided herein, Executive shall not be required to mitigate damages or the amount of any
payment provided under this Agreement by seeking other employment or otherwise, nor shall the amount of any payment provided for under this Agreement be reduced by any compensation earned by Executive as a result of employment by another employer or
by any retirement benefits received by Executive after the date of termination of his employment with the Company. 
 (f)
Termination of Benefits. Benefits under this Agreement shall terminate immediately if the Executive, at any time, violates any proprietary information or confidentiality obligation to the Company. 
 (g) Non-Duplication of Benefits. Executive is not eligible to receive benefits under this Agreement more than one time. 
 (h) Compliance with Section 409A. To the extent necessary to comply with the distribution requirements contained in Section 409A
of the Internal Revenue Code, including, without limitation, the requirement of Section 409A(a)(2)(B)(i), payments to Executive under this Agreement shall be delayed until the first regular payroll date that occurs more than six (6) months
after “separation from service” (within the meaning described in Section 409A and its related regulations) if Executive is a “specified employee” within the meaning of Section 409A at the time of such separation from
service. 
 7. NON-SOLICITATION AND NON-DISCLOSURE. 
 (a) Non-Solicitation. During the period commencing on the date of this Agreement and continuing until (i) the date Executive’s
Employment terminates if the Company terminates Executive’s Employment for any reason other than Cause, or (ii) the first anniversary of the date Executive’s Employment terminates if Executive resigns for any reason or the Company
terminates Executive’s Employment for Cause, the Executive shall not directly or indirectly, personally or through others, solicit or attempt to solicit (on the Executive’s own behalf or on behalf of any other person or entity) the
employment of any employee of the Company or any of the Company’s affiliates. 
 (b) Non-Disclosure. As a condition of
employment the Executive has entered into a Proprietary Information Agreement with the Company, which is incorporated herein by reference. 
 8.
SUCCESSORS. 
 (a) Company’s Successors. This Agreement shall be binding upon any successor (whether direct or
indirect and whether by purchase, lease, merger, consolidation, liquidation or otherwise) to all or substantially all of the Company’s business and/or assets. For all purposes under this Agreement, the term “Company” shall include any
successor to the Company’s business and/or assets which becomes bound by this Agreement. 
  

 6. 

 (b) Executive’s Successors. This Agreement and all rights of the Executive hereunder
shall inure to the benefit of, and be enforceable by, the Executive’s personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees and legatees. 
 9. MISCELLANEOUS PROVISIONS. 
 (a) Notice. Notices and all other communications contemplated by this Agreement shall be in writing and shall be deemed to have been duly given when personally delivered or when mailed by overnight courier, U.S. registered or
certified mail, return receipt requested and postage prepaid. In the case of the Executive, mailed notices shall be addressed to him at the home address which he most recently communicated to the Company in writing. In the case of the Company,
mailed notices shall be addressed to its corporate headquarters, and all notices shall be directed to the attention of its Secretary. 
 (b) Modifications and Waivers. No provision of this Agreement shall be modified, waived or discharged unless the modification, waiver or discharge is agreed to in writing and signed by the Executive and by an authorized
officer of the Company (other than the Executive), No waiver by either party of any breach of, or of compliance with, any condition or provision of this Agreement by the other party shall be considered a waiver of any other condition or provision or
of the same condition or provision at another time. 
 (c) Whole Agreement. The Prior Agreement is hereby amended in its
entirety and restated herein. Such amendment and restatement is effective upon the execution of this Agreement by the Company and Executive. Upon such execution, all provisions of, rights granted and covenants made in the Prior Agreement are hereby
waived, released and superseded in their entirety and shall have no further force or effect. No other agreements, representations or understandings (whether oral or written) which are not expressly set forth in this Agreement have been made or
entered into by either party with respect to the subject matter of this Agreement. This Agreement and the Proprietary Information Agreement contain the entire understanding of the parties with respect to the subject matter hereof. 
 (d) Withholding Taxes. All payments made under this Agreement shall be subject to reduction to reflect taxes or other charges required to
be withheld by law. 
 (e) Choice of Law. The validity, interpretation, construction and performance of this Agreement shall be
governed by the laws of the State of California (except provisions governing the choice of law). 
 (f) Severability. The
invalidity or unenforceability of any provision or provisions of this Agreement shall not affect the validity or enforceability of any other provision hereof, which shall remain in full force and effect. 
 (g) Arbitration. Any controversy or claim arising out of or relating to this Agreement or the breach thereof, or the Executive’s
Employment or the termination thereof, shall be settled in South San Francisco, California, by arbitration in accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration Association. The decision of the
arbitrator shall be final and binding on the patties, and judgment on the award rendered by the arbitrator may be entered in any court having jurisdiction thereof. The arbitration 

  

 7. 

 
will be in lieu of a jury trial and Executive and the Company each waive their right to a jury trial. The parties hereby agree that the arbitrator shall be
empowered to enter an equitable decree mandating specific enforcement of the terms of this Agreement. The Company and the Executive shall share equally all fees and expenses of the arbitrator. Both parties hereby consent to personal jurisdiction of
the state and federal courts located in the State of California for any action or proceeding arising from or relating to this Agreement or relating to any arbitration in which the parties are participants. 
 (h) No Assignment. This Agreement and all rights and obligations of the Executive hereunder are personal to the Executive and may not be
transferred or assigned by the Executive at any time. The Company may assign its rights under this Agreement to any entity that assumes the Company’s obligations hereunder in connection with any sale or transfer of all or a substantial portion
of the Company’s assets to such entity. 
 (i) Counterparts. This Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 IN
WITNESS WHEREOF, each of the parties has executed this Agreement, in the case of the Company by its duly authorized officer, as of the day and year first above written. 
  

			
	WILLIAM D. YOUNG
	
	/s/ William D. Young
	
	MONOGRAM BIOSCIENCES, INC.
		
	By:	 	/s/ Kathy Hibbs
	Title:	 	Senior Vice President and General Counsel

  

 8. 

 [Exhibit A – Form of Release] 
 GENERAL RELEASE OF ALL CLAIMS 
 In consideration of the benefits to be paid to
me by Monogram Biosciences, Inc. in accordance with the Second Amended and Restated Employment Agreement entered into effective as of December 18, 2008, I hereby fully and forever release and discharge Monogram Biosciences, Inc. and its
directors, officers, employees, agents, successors, predecessors, subsidiaries, shareholders, employee benefit plans and assigns (together the “Company”), from all claims and causes of action arising out of or relating in any way to my
employment with the Company, including the termination of my employment. 
 1. I understand and agree that this RELEASE is a full and
complete waiver of all claims, including (without limitation) claims of wrongful discharge, breach of contract, breach of the covenant of good faith and fair dealing, violation of public policy, defamation, personal injury or emotional distress and
claims under Title VII of the Civil Rights Act of 1964, as amended, the Fair Labor Standards Act, the Equal Pay Act of 1963, the Americans with Disabilities Act, the Civil Rights Act of 1866, the Age Discrimination in Employment Act of 1967, as
amended (ADEA), the California Fair Employment and Housing Act, the Family and Medical Leave Act or any federal or state law or regulation relating to employment or employment discrimination. I further understand and agree that this RELEASE is a
full and complete waiver of all claims, including (without limitation) claims under the Employee Retirement Income Security Act of 1974 (ERISA) related to severance benefits. I further understand that by this RELEASE I agree not to assist,
encourage, institute or cause to be instituted the filing of any administrative charge or legal proceeding against the Company relating to employment discrimination. 
 2. I also hereby agree that nothing contained in this RELEASE shall constitute or be treated as an admission of liability or wrongdoing by me or the Company. This RELEASE does not relieve the Company of its
obligations to comply with the terms of the Employment Agreement, any stock option agreement or any employee benefit plan or similar program in which I am a participant or eligible for benefits. 
 3. I agree to abide by Company’s Proprietary Information and Inventions Agreement that I previously executed. 
 4. In addition, I hereby expressly waive any and all rights and benefits conferred upon me by the provisions of Section 1542 of the Civil Code of
the State of California (or any analogous law of any other state), which states as follows: 
 A general release does not extend to claims
which the creditor does not know or suspect to exist in his favor at the time of executing the release, which, if known by him, must have materially affected his settlement with the debtor. 
 5. I hereby acknowledge that I have read and understand the foregoing RELEASE and that I sign it voluntarily and without coercion. I further acknowledge
that I was given an opportunity to consider and review this RELEASE and to consult with an attorney of my own choosing concerning the waivers contained in this RELEASE and that the waivers are knowing, conscious and with full appreciation that I am
forever foreclosed from pursuing any of the rights that I waived. 
  

 1. 

 6. I understand that I may have up to twenty-one (21) days after receipt of this letter within which
I may review and consider, discuss with an attorney of my own choosing, and decide to execute or not execute it. I also understand for a period of seven (7) days after I sign this RELEASE, I may revoke this RELEASE and that the RELEASE will not
become effective until seven (7) days after I sign it, and only then if I do not revoke it. In order to revoke this agreement, I must deliver to the Chairman of the Board of Monogram Biosciences, Inc. within seven (7) days after I have
executed this RELEASE, a letter stating that I am revoking it. 
 7. I understand that if I choose to revoke this RELEASE within seven
(7) days after I signed it, I will not receive any severance benefit and the RELEASE will have no effect. 
 8. Before signing my name
to this RELEASE, I state that:  
  ̈ I have read it, 
  ̈ I understand it, 
  ̈ I know that I am giving up important rights, 
  ̈ I am aware of my right to consult an attorney before signing it, and 
  ̈ I
have signed it knowingly and voluntarily. 
  

							
	Dated:	 	  	 		 	  
		 		 		 	Signature
				
	 	 	 	 		 	  
		 		 		 	Print Full Name

  

 2.Form of Executive Severance Benefits Agreement

 Exhibit 10.8 
 EXECUTIVE SEVERANCE BENEFITS AGREEMENT 
 THIS EXECUTIVE
SEVERANCE BENEFITS AGREEMENT (the “AGREEMENT”) is entered into this ___ day of _____________, _____ (the “Effective Date”),
between _____________________ (“EXECUTIVE”) and Monogram Biosciences Inc. (the “COMPANY”). This Agreement is intended to provide Executive with the compensation
and benefits described herein upon the occurrence of specific events. Certain capitalized terms used in this Agreement are defined in Article 5. 
 The Company and Executive hereby agree as follows: 
 ARTICLE 1 
 SCOPE OF AND CONSIDERATION FOR THIS AGREEMENT 
 1.1 Executive is currently employed by the Company. 
 1.2 The Company and Executive wish to set forth the compensation and benefits which Executive shall be entitled to receive in the event Executive’s employment with the Company is terminated under the
circumstances described herein following a Change in Control. 
 1.3 The duties and obligations of the Company to Executive under this
Agreement shall be in consideration for Executive’s past services to the Company, Executive’s continued employment with the Company, and Executive’s execution of a release in accordance with Section 3.1. 
 1.4 This Agreement shall supersede any other agreement relating to cash severance benefits, health benefits in the event of Covered Termination
following a Change in Control. 
 ARTICLE 2 
 SEVERANCE BENEFITS 
 2.1 Severance Benefits. A Covered
Termination (as defined in Article 4) entitles Executive to receive the benefits set forth in Sections 2.2 and 2.3. 
 2.2
Severance Payment. In the circumstances described in Section 2.1, Executive shall receive a severance payment equal to (i) one times the greater of (x) the Fixed Amount or (y) Executive’s Base Salary plus
(ii) the amount of the target bonus established for Executive for the last completed fiscal year immediately preceding the Covered Termination. Such amount shall be subject to all required tax withholding and shall be paid in a lump sum upon
the later of (a) Executive’s compliance with Section 3.1 herein or (b) the effective date of the related Change in Control. 
 2.3 Health Insurance Coverage. If the Executive elects to continue his health insurance coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”) following the termination of his Employment, then the
Company shall pay the Executive’s monthly premium under COBRA until the earliest of (i) the close of the Continuation Period or (ii) the expiration of the Executive’s continuation coverage under COBRA. 
  

 1. 

 2.4 Mitigation. Except as otherwise specifically provided herein, Executive shall not be
required to mitigate damages or the amount of any payment provided under this Agreement by seeking other employment or otherwise, nor shall the amount of any payment provided for under this Agreement be reduced by any compensation earned by
Executive as a result of employment by another employer or by any retirement benefits received by Executive after the date of the Covered Termination. 
 2.5 Compliance with Section 409A. Benefits payable under this Agreement, to the extent of payments made from the date of Executive’s termination through March 15th of the calendar year
following such termination, are intended to constitute separate payments for purposes of Section 1.409A-2(b)(2) of the Treasury Regulations and thus payable pursuant to the “short-term deferral” rule set forth in
Section 1.409A-1(b)(4) of the Treasury Regulations; to the extent such payments are made following said March 15th, they are intended to constitute separate payments for purposes of Section 1.409A-2(b)(2) of the Treasury Regulations
made upon an involuntary termination from service and payable pursuant to Section 1.409A-1(b)(9)(iii) of the Treasury Regulations, to the maximum extent permitted by said provision, with any excess amount being regarded as subject to the
distribution requirements of Section 409A(a)(2)(A) of the Code, including, without limitation, the requirement of Section 409A(a)(2)(B)(i) of the Code that payment to Executive be delayed until six (6) months after separation from
service if Executive is a “specified employee” within the meaning of the aforesaid section of the Code at the time of such separation from service. 
 ARTICLE 3 
 LIMITATIONS AND CONDITIONS
ON BENEFITS 
 3.1 Release Prior To Payment Of Benefits. Upon the occurrence of a Covered
Termination, and prior to the payment of any benefits under this Agreement on account of such Covered Termination, Executive shall execute a release (the “Release”) in the form attached hereto and incorporated herein as Exhibit A
within the time period set forth therein (but in no event later than forty-five (45) days after the date of termination). Such Release shall specifically relate to all of Executive’s rights and claims in existence at the time of such
execution and shall confirm Executive’s obligations under the Company’s standard form of proprietary information and inventions agreement. It is understood that, as specified in the applicable Release, Executive has a certain number of
calendar days to consider whether to execute such Release, and Executive may revoke such Release within seven (7) calendar days after execution. In the event Executive does not execute such Release within the applicable period, or if Executive
revokes such Release within the subsequent seven (7) day period, no benefits shall be payable under this Agreement, and this Agreement shall be null and void. 
  

 2. 

 3.2 Termination of Benefits. Benefits under this Agreement shall terminate immediately if
the Executive, at any time, violates any proprietary information or confidentiality obligation to the Company. 
 3.3
Non-Duplication of Benefits. Executive is not eligible to receive benefits under this Agreement more than one time. 
 ARTICLE 4

 DEFINITIONS 
 For purposes of the Agreement, the following terms are defined as follows: 
 4.1 “Base Salary” means
Executive’s annual base salary as in effect during the last completed fiscal year immediately preceding the Covered Termination. 
 4.2 “Board” means the Board of Directors of the Company. 
 4.3 “Cause” means that,
in the reasonable determination of the Company or, in the case of the Chief Executive Officer, the Board, Executive: 
 (a) has willfully or recklessly, and repeatedly failed to satisfactorily perform the Executive’s job duties, after being given written notice of the failure to perform and an opportunity to cure such deficiency; 
 (b) has committed an act that materially injures the business of the Company; 
 (c) has misappropriated property belonging to the Company or has violated any of his proprietary information or confidentiality
obligations to the Company; or 
 (d) has been convicted of a felony involving moral turpitude that is likely to
inflict or has inflicted material injury on the business of the Company. 
 4.4 “Change in Control” means 

(a) a sale or other disposition of all or substantially all of the assets of the Company; 
 (b) a merger or consolidation in which the Company is not the surviving entity and in which the stockholders of the Company
immediately prior to such consolidation or merger own less than fifty percent (50%) of the surviving entity’s voting power immediately after the transaction; 
 (c) a reverse merger in which the Company is the surviving entity but the shares of Common Stock outstanding immediately preceding
the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise, and in which the stockholders of the Company immediately prior to such reverse merger own less than fifty percent
(50%) of the Company’s voting power immediately after the transaction; 
  

 3. 

 (d) after the Listing Date as defined in the Company’s Equity Incentive Plan,
an acquisition by any person, entity or group within the meaning of Section 13(d) or 14(d) of the Exchange Act, or any comparable successor provisions (excluding any employee benefit plan, or related trust, sponsored or maintained by the
Company or subsidiary of the Company or other entity controlled by the Company) of the beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act, or comparable successor rule) of securities of the Company representing
at least fifty percent (50%) of the voting power entitled to vote in the election of Directors; or 
 (e) in the
event that the individuals who, as of the date of adoption of the Plan, are members of the Company’s Board (the “Incumbent Board”), cease for any reason to constitute at least fifty percent (50%) of the Board. (If the election,
or nomination for election by the Company’s stockholders, of any new Director is approved by a vote of at least fifty percent (50%) of the Incumbent Board, such new Director shall be considered to be a member of the Incumbent Board in the
future.) 
 4.5 “Company” means Monogram Biosciences, Inc. or, following a Change in Control, the surviving entity
resulting from such transaction. 
 4.6 “Constructive Termination” means the Executive’s resignation from
employment with the Company resulting from the occurrence of any of the following events without the Executive’s express written consent: 
 (a) a change in Executive’s responsibilities which represents material adverse change from the Executive’s responsibilities as in effect at any time within ninety (90) days preceding the
effective date of a Change in Control or at any time thereafter, or the assignment to Executive of any duties or responsibilities which are materially and adversely inconsistent with the Executive’s duties and responsibilities in effect at any
time within ninety (90) days preceding the effective date of a Change of Control or at any time thereafter; 
 (b)
a material reduction by the Company in Executive’s overall compensation package [or any failure to pay Executive any compensation or benefits to which Executive is entitled within fifteen (15) days of the date due; 
 (c) the Company’s relocation of Executive to any place outside a fifty (50) mile radius of the Executive’s current
worksite, except for reasonably required travel on the business of the Company and/or its affiliates which is not materially greater than such travel requirements prior to the effective date of the Change of Control; 
 (d) the failure by the Company to: (i) continue in effect (without reduction in benefit level and/or reward opportunities) any
material compensation or employee benefit plan in which the Executive was participating at any time within ninety (90) days preceding the effective date of a Change in Control or at any time thereafter, unless such plan is replaced with a plan
that provides substantially equivalent compensation or benefits to Executive (it being understood that changes to any such plans necessitated by the need to conform Executive’s and the Company’s other employees’, as a whole,
compensation and benefits packages to those of the surviving corporation and/or acquiror (as applicable) shall not alone constitute Constructive Termination unless such changes result in a material reduction in 

  

 4. 

 
Executive’s overall annual compensation package as described in subsection (B) above), or (ii) provide Executive with compensation and
benefits, in the aggregate, at least substantially similar (in terms of benefit levels and/or reward opportunities) to those provided for under each other employee benefit plan, program and practice in which the Executive was participating at any
time within ninety (90) days preceding the effective date of a Change in Control or at any time thereafter; 
 (e)
a material breach by the Company of any provision of this Agreement, unless such breach is cured within fifteen (15) days following notice by the Executive of such breach; or 
 (f) any failure by the Company to obtain the assumption of this Agreement by the surviving corporation and/or acquiror (as
applicable) of the Company. 
 Notwithstanding the foregoing, the Executive’s resignation will be deemed a
“Constructive Termination” only if: (a) the Executive notifies the Company in writing, within 30 days after the occurrence of one of the foregoing events, that he or she intends to terminate his or her employment no earlier than 30
days after providing such notice; (b) the Company does not cure such condition within 30 days following its receipt of such notice or states unequivocally in writing that it does not intend to attempt to cure such condition; and (c) the
Executive resigns from employment within 30 days following the end of the period within which the Company was entitled to remedy the condition constituting the Constructive Termination but failed to do so. 
 4.7 “Covered Termination” means an Involuntary Termination Without Cause or a Constructive Termination within three
(3) months prior to or twenty-four (24) months following the effective date of a Change in Control. 
 4.8 “Fixed
Amount” means [            ]. [AMOUNT EQUIVALENT TO EXECUTIVE’S 2008 ANNUAL
SALARY.] [Amount equal to initial base salary for new executives.] 
 4.9 “Involuntary Termination Without
Cause” means Executive’s dismissal or discharge other than for Cause. The termination of Executive’s employment as a result of Executive’s death or disability will not be deemed to be an Involuntary Termination Without Cause.

 ARTICLE 5 
 GENERAL PROVISIONS 
 5.1 Employment Status; Employment Agreement Superseded.
This Agreement does not constitute a contract of employment or impose upon Executive any obligation to remain as an employee, or impose on the Company any obligation (i) to retain Executive as an employee, (ii) to change the status of
Executive as an at-will employee, or (iii) to change the Company’s policies regarding termination of employment. In the event of any conflict between the provisions of this Agreement and the provisions of any other previously existing
employment, severance or other similar agreement, then the provisions of this Agreement shall govern. 
  

 5. 

 5.2 Notices. Any notices provided hereunder must be in writing, and such notices or any
other written communication shall be deemed effective upon the earlier of personal delivery (including personal delivery by facsimile) or the third day after mailing by first class mail, to the Company at its primary office location and to Executive
at Executive’s address as listed in the Company’s payroll records. Any payments made by the Company to Executive under the terms of this Agreement shall be delivered to Executive either in person or at the address as listed in the
Company’s payroll records. 
 5.3 Severability. Whenever possible, each provision of this Agreement will be interpreted in
such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity, illegality or
unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such invalid, illegal or unenforceable provisions had never been contained herein.

 5.4 Waiver. If either party should waive any breach of any provisions of this Agreement, he or it shall not thereby be
deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 
 5.5
Arbitration. Unless otherwise prohibited by law or specified below, all disputes, claims and causes of action, in law or equity, arising from or relating to this Agreement or its enforcement, performance, breach, or interpretation shall be
resolved solely and exclusively by final and binding arbitration held in San Diego County, California through Judicial Arbitration & Mediation Services/Endispute (“JAMS”) under the then existing JAMS arbitration rules. However,
nothing in this section is intended to prevent either party from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration. Each party in any such arbitration shall be responsible for its own
attorneys’ fees, costs and necessary disbursement; provided, however, that in the event one party refuses to arbitrate and the other party seeks to compel arbitration by court order, if such other party prevails, it shall be entitled to
recover reasonable attorneys’ fees, costs and necessary disbursements. Pursuant to California Civil Code Section 1717, each party warrants that it was represented by counsel in the negotiation and execution of this Agreement, including the
attorneys’ fees provision herein. 
 5.6 Complete Agreement. This Agreement, including Exhibit A, constitutes the
entire agreement between Executive and the Company and is the complete, final, and exclusive embodiment of their agreement with regard to this subject matter, wholly superseding all written and oral agreements with respect to cash severance benefits
and health benefits to Executive in the event of employment termination other than any outstanding loans by the Company to Executive. It is entered into without reliance on any promise or representation other than those expressly contained herein.

 5.7 Amendment Or Termination Of Agreement. This Agreement may be changed or terminated only upon the mutual written consent
of the Company and Executive. The written consent of the Company to a change or termination of this Agreement must be signed by an executive officer of the Company after such change or termination has been approved by the Board. 
  

 6. 

 5.8 Counterparts. This Agreement may be executed in separate counterparts, any one of which
need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 
 5.9
Headings. The headings of the Articles and Sections hereof are inserted for convenience only and shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 
 5.10 Successors And Assigns. This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive, and the
Company, and any surviving entity resulting from a Change in Control and upon any other person who is a successor by merger, acquisition, consolidation or otherwise to the business formerly carried on by the Company, and their respective successors,
assigns, heirs, executors and administrators, without regard to whether or not such person actively assumes any rights or duties hereunder; provided, however, that Executive may not assign any duties hereunder and may not assign any rights
hereunder without the written consent of the Company, which consent shall not be withheld unreasonably. 
 5.11 Choice Of Law.
All questions concerning the construction, validity and interpretation of this Agreement will be governed by the law of the State of California, without regard to such state’s conflict of laws rules. 
 5.12 Non-Publication. The parties mutually agree not to disclose publicly the terms of this Agreement except to the extent that disclosure
is mandated by applicable law or to respective advisors (e.g., attorneys, accountants). 
 5.13 Construction Of
Agreement. In the event of a conflict between the text of the Agreement and any summary, description or other information regarding the Agreement, the text of the Agreement shall control. 
 IN WITNESS WHEREOF, the parties have executed this Agreement on the Effective Date written above.

  

									
	MONOGRAM BIOSCIENCES, INC.	 		 		 	[EXECUTIVE NAME]
					
	By:	 	 	 		 		 	 
					
	Name:	 	 	 		 		 	
					
	Title:	 	 	 		 		 	

  

 7. 

 Exhibit A: Release 
  

 8. 

 EXHIBIT A 
 RELEASE 
 Certain capitalized terms used in this Release are defined in the
Executive Severance Benefits Agreement (the “Agreement”), which I have executed and of which this Release is a part. 
 I hereby
confirm my obligations under the Company’s proprietary information and inventions agreement. 
 I acknowledge that I have read and
understand Section 1542 of the California Civil Code which reads as follows: “A general release does not extend to claims which the creditor does not know or suspect to exist in his favor at the time of executing the release, which if
known by him must have materially affected his settlement with the debtor.” I hereby expressly waive and relinquish all rights and benefits under that section and any law of any jurisdiction of similar effect with respect to my release of
any claims I may have against the Company. 
 Except as otherwise set forth in this Release, I hereby release, acquit and forever discharge
the Company, its parents and subsidiaries, and their officers, directors, agents, servants, employees, shareholders, successors, assigns and affiliates, of and from any and all claims, liabilities, demands, causes of action, costs, expenses,
attorneys fees, damages, indemnities and obligations of every kind and nature, in law, equity, or otherwise, known and unknown, suspected and unsuspected, disclosed and undisclosed (other than any claim for indemnification I may have as a result of
any third party action against me based on my employment with the Company), arising out of or in any way related to agreements, events, acts or conduct at any time prior to the date I execute this Release, including, but not limited to: all such
claims and demands directly or indirectly arising out of or in any way connected with my employment with the Company or the termination of that employment, including but not limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related to salary, bonuses, commissions, stock, stock options, or any other ownership interests in the Company, vacation pay, fringe benefits, expense reimbursements, severance
pay, or any other form of disputed compensation; claims pursuant to any federal, state or local law or cause of action including, but not limited to, the federal Civil Rights Act of 1964, as amended; the federal Age Discrimination in Employment Act
of 1967, as amended (“ADEA”); the federal Employee Retirement Income Security Act of 1974, as amended; the federal Americans with Disabilities Act of 1990; the California Fair Employment and Housing Act, as amended; tort law; contract law;
statutory law; common law; wrongful discharge; discrimination; fraud; defamation; emotional distress; and breach of the implied covenant of good faith and fair dealing; provided, however, that nothing in this paragraph shall be construed in
any way to release the Company from its obligation to indemnify me pursuant to the Company’s indemnification obligation pursuant to agreement or applicable law. 
  

 1. 

 I acknowledge that I am knowingly and voluntarily waiving and releasing any rights I may have under ADEA.
I also acknowledge that the consideration given under the Agreement for the waiver and release in the preceding paragraph hereof is in addition to anything of value to which I was already entitled. I further acknowledge that I have been advised by
this writing, as required by the ADEA, that: (A) my waiver and release do not apply to any rights or claims that may arise on or after the date I execute this Release; (B) I have the right to consult with an attorney prior to executing
this Release; (C) I have twenty-one (21) days to consider this Release (although I may choose to voluntarily execute this Release earlier); (D) I have seven (7) days following the execution of this Release by the parties to
revoke the Release; and (E) this Release shall not be effective until the date upon which the revocation period has expired, which shall be the eighth day after this Release is executed by me. 
  

			
	[EXECUTIVE NAME]
	
	 
		
	Date:	 	 
		 	

  

 2.

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