Document:

Exhibit 10.1

 

AGREEMENT
ON MILESTONE PAYMENTS AND ROYALTIES

 

This AGREEMENT ON MILESTONE PAYMENTS AND ROYALTIES is entered into by and between ArQule, Inc.
and Daiichi Sankyo Co., Ltd. (collectively, the “Parties”).

 

WHEREAS, the Parties have entered into that certain Collaborative Research, Development and License
Agreement (the “Agreement”) on November 7,
2008;

 

WHEREAS, Section 5.4 of the
Agreement provides that the Parties shall
negotiate in good faith and reach agreement on an amendment to the Agreement or
a separate agreement to be executed by the Parties setting forth certain
milestone payments and royalties to be paid under the License Agreement for
each Licensed Product that is Developed and Commercialized under the Agreement
and/or a License Agreement and additional provisions relating thereto; and

 

WHEREAS, the Parties have
agreed upon the milestone events, the amount of milestone payments and sales
milestone payments, and the royalty rates at this time, and to negotiate other
provisions later.

 

NOW, THEREFORE, in
consideration of the mutual promises set forth herein and for other good and
valuable consideration, the receipt and sufficiency of which is acknowledged by
the Parties, the Parties hereto, intending to be legally bound, hereby  agree as follows:

 

1.             Terms which are defined in the Agreement are used herein
as so defined.

 

2              The Parties agree that the timing of milestone payments
and the amount of milestone payments and sales milestone payments and the royalty rates to be included in each License
Agreement are as attached hereto as Exhibit A.

 

3              The Parties agree that any term and condition described
in Exhibit A of this agreement and
Schedule 3 of the Agreement (except as modified
in Exhibit A of this agreement) shall be included in each License Agreement.

 

4              Notwithstanding Section 5.4 of the Agreement, the
Parties agree to negotiate such
additional provisions relating to royalty reports, payment mechanisms and
dates, audit rights, overdue payments, taxes, currency conversion rates and
other provisions as are usual and customary for inclusion in provisions relating
to milestones and royalties at the time of
negotiation of each License Agreement. For
purpose of clarity, such additional provisions shall supplement and shall not
materially expand, limit or change any term and condition agreed in this
agreement or set forth in Schedule 3 of the License Agreement (except as
modified in Exhibit A of this agreement).

 

This agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one and the same agreement.

 

*   *   *  
*   *   *   *   *

 

[*]
= CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION. 
CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED
PORTIONS.  OMITTED TEXT IS INDICATED BY
AN “*”.

 

 

	
   

  	
  ArQule, Inc.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/
  Paolo Pucci

  
	
   

  	
   

  	
  Name: Paolo Pucci

  
	
   

  	
   

  	
  Title: Chief Executive Officer

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  Daiichi
  Sankyo Co., Ltd.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/
  Takashi Shoda

  
	
   

  	
   

  	
  Name: Takashi
  Shoda

  
	
   

  	
   

  	
  Title: President
  and Chief Executive Officer

  

 

 

Exhibit A

 

Milestone Payments and Royalties

 

A. Development and Regulatory Milestones

 

	
  Milestone Event

  	
   

  	
  Milestone Payment

  	
   

  
	
  1. *

  	
   

  	
  $* million

  	
   

  
	
  2. *

  	
   

  	
  $* million

  	
   

  
	
  3. *

  	
   

  	
  $* million

  	
   

  
	
  4. *

  	
   

  	
  $* million

  	
   

  
	
  5. *

  	
   

  	
  $* million

  	
   

  
	
  6. *

  	
   

  	
  $* million

  	
   

  
	
  7. *

  	
   

  	
  $* million

  	
   

  
	
  8. *

  	
   

  	
  $* million

  	
   

  
	
  9. *

  	
   

  	
  $* million

  	
   

  
	
  10. *

  	
   

  	
  $* million

  	
   

  
	
  11. *

  	
   

  	
  $* million

  	
   

  
	
  12. *

  	
   

  	
  $* million

  	
   

  
	
  13. *

  	
   

  	
  $* million

  	
   

  
	
  14. *

  	
   

  	
  $* million

  	
   

  
	
  15. *

  	
   

  	
  $* million

  	
   

  
	
  16. *

  	
   

  	
  $* million

  	
   

  
	
  17. *

  	
   

  	
  $* million

  	
   

  
	
  19. *

  	
   

  	
  $* million

  	
   

  
	
  20. *

  	
   

  	
  $* million

  	
   

  
	
  21. *

  	
   

  	
  $* million

  	
   

  
	
  22. *

  	
   

  	
  $* million

  	
   

  

 

 

B. Sales Milestones

 

	
  Milestone Event

  	
   

  	
  Milestone Payment

  	
   

  
	
  Annual Net Sales in a Calendar Year of $* million

  	
   

  	
  $* million

  	
   

  
	
  Annual Net Sales in a Calendar Year of $* million

  	
   

  	
  $* million

  	
   

  
	
  Annual Net Sales in a Calendar Year of $* billion

  	
   

  	
  $* million

  	
   

  
	
  Annual Net Sales in a Calendar Year of $* billion

  	
   

  	
  $* million

  	
   

  

 

C. Royalties

 

	
  Annual Net Sales Increment in
  the Territory

  	
   

  	
  Royalty Rate  

  applicable for such tier

  	
   

  
	
  Up
  to $* million

  	
   

  	
  *%

  	
   

  
	
  Above $* million, but less than or equal to $*
  billion

  	
   

  	
  *%

  	
   

  
	
  Above $* billion

  	
   

  	
  *%Exhibit
10.1

 

 

June 17,
2009

 

Michael
N. Chang, Ph.D.

Optimer
Pharmaceuticals, Inc.

10110
Sorrento Valley Road, Suite C

San
Diego, CA 92121

 

Re:          Amendment to Employment Agreement

 

Dear
Michael:

 

This
Amendment (the “Amendment”)
to your Employment Agreement with Optimer Pharmaceuticals, Inc.
(the “Company”) dated June 17, 2005, as
amended (the “Agreement”),
amends the terms and conditions of the Agreement to the extent provided
herein. The Agreement is currently scheduled to expire according to its terms on
June 17, 2009 and you and the Company have expressed a desire to continue
the Agreement for an additional 4 year term.

 

In
light of the foregoing, Section 2.3 of the Agreement shall be amended and
restated in its entirety to read as follows:

 

“2.3.
Term of Employment. The Executive’s employment
under this Agreement (the “Employment Term”) shall commence as of the effective date hereof and
shall terminate on the earlier of (a) the eighth year anniversary of the
date hereof, or (b) the termination of the Executive’s employment pursuant
to this Agreement. Executive may terminate his employment with the Company at
any time and for any reason upon thirty (30) days’ prior written notice to the
Company.”

 

Except
as specifically amended by this Amendment, the terms and conditions of the
Agreement shall remain in full force and effect. This Amendment may be executed
in two or more counterparts, each of which shall be deemed an original and all
of which together shall constitute one and the same instrument. Please sign
this Amendment and return it to the Company at your earliest convenience.

 

Sincerely,

 

	
  OPTIMER PHARMACEUTICALS, INC.

  
	
   

  
	
  By:  

  	
  /s/
  Alain Schreiber, M.D.

  	
   

  	
   

  
	
   

  	
  Alain
  Schreiber, M.D.

  	
   

  	
   

  
	
   

  	
  Director

  	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  Accepted
  and Agreed:

  
	
   

  	
   

  
	
   

  	
  /s/ Michael N. Chang, Ph.D.

  
	
   

  	
  Michael N. Chang, Ph.D.

  

 

10110 SORRENTO VALLEY ROAD, SUITE C SAN DIEGO, CALIFORNIA 92121
TEL:858-909-0736 FAX:858-909-0737Exhibit 10.1

 

General Maritime Corporation

Restricted Stock Grant Agreement

 

THIS AGREEMENT is made as
of May 14, 2009, between GENERAL MARITIME CORPORATION (the “Company”) and
WILLIAM J. CRABTREE (the “Participant”).

 

WHEREAS, the Company has
adopted and maintains the General Maritime Corporation 2001 Stock Incentive
Plan, as amended (the “Plan”) to provide certain key persons, on whose
initiative and efforts the successful conduct of the business of the Company
depends, and who are responsible for the management, growth and protection of
the business of the Company, with incentives to: (a) enter into and remain
in the service of the Company, a Company subsidiary or a Company joint venture,
(b) acquire a proprietary interest in the success of the Company, (c) maximize
their performance and (d) enhance the long-term performance of the Company
(whether directly or indirectly through enhancing the long-term performance of
a Company subsidiary or a Company joint venture);

 

WHEREAS, the Plan
provides that the Compensation Committee (the “Committee”) of the Board of
Directors (or the Board of Directors if it so elects) shall administer the Plan
and determine the key persons to whom awards shall be granted and the amount
and type of such awards; and

 

WHEREAS, the Board of
Directors has determined that the purposes of the Plan would be furthered by
granting the Participant an award under the Plan as set forth in this
Agreement;

 

NOW, THEREFORE, in
consideration of the premises and the mutual covenants hereinafter set forth,
the parties hereto hereby agree as follows:

 

1.             Grant of Restricted Stock.  Pursuant
to, and subject to, the terms and conditions set forth herein and in the Plan,
the Committee hereby grants to the Participant 7,042 restricted shares (the “Restricted
Stock”) of common stock of the Company, par value $0.01 per share (“Common
Stock”).

 

2.             Grant Date.  The
Grant Date of the Restricted Stock is May 14, 2009.

 

3.             Incorporation of Plan.  All
terms, conditions and restrictions of the Plan are incorporated herein and made
part hereof as if stated herein.  If there is any conflict between
the terms and conditions of the Plan and this Agreement, the terms and
conditions of the Plan, as interpreted by the Committee, shall
govern.  Except as otherwise provided herein, all capitalized terms
used herein shall have the meaning given to such terms in the Plan.

 

4.             Vesting.  Subject to the further provision of this
Agreement, the Restricted Stock shall vest on the earliest of (i) May 14,
2010, (ii) the date of the next annual meeting of the Company to follow
the date hereof and (ii) the occurrence of a Change in Control, as defined
in 

 

 

Section 3.8(a) of
the Plan, as in effect on the date of such occurrence (each such date, the “Vesting
Date”).

 

5.             Restrictions on Transferability.  Until a share of Restricted Stock vests, the
Participant shall not transfer the Participant’s rights to such share of
Restricted Stock or to any rights related thereto.  Any attempt to transfer unvested shares of
Restricted Stock or any rights related thereto, whether by transfer, pledge,
hypothecation or otherwise and whether voluntary or involuntary, by operation
of law or otherwise, shall not vest the transferee with any interest or right
in or with respect to such shares of Restricted Stock or such related rights.

 

6.             Termination of Service.  In the event that the Participant’s service
with the Company terminates before the Vesting Date for any reason other than
the Participant’s death or disability, the Restricted Stock, together with any
property received in respect thereof, as set forth in Section 10 hereof,
shall be forfeited as of the date of such termination of service, and the
Participant promptly shall return to the Company any certificates evidencing
the Restricted Stock.  Any cash dividends
or other property received in respect of the Restricted Stock also shall be
forfeited, unless the Board or the Committee determines otherwise.  For purposes of this Agreement, the
Participant’s service shall terminate only when the Participant is not a
director, an employee or a consultant of the Company, as set forth in Section 1.6(c) of
the Plan.

 

7.             Death or Disability.  In the event that the Participant dies or the
Participant’s service with the Company terminates due to the Participant’s disability
(within the meaning of Section 2.5(d) of the Plan) before the Vesting
Date, the Restricted Stock shall become vested in full as of the date of such
death or termination of service.

 

8.             Issuance of Certificates.

 

(a)           Reasonably promptly after the Grant
Date, the Company shall issue and deliver to the Participant a stock
certificate, registered in the name of the Participant, evidencing the shares
of Restricted Stock or shall instruct its transfer agent to issue shares of
Restricted Stock which shall be maintained in book entry form on the books of
the transfer agent.  The Restricted
Stock, if certificated, shall bear the following legend:

 

“THE SALE, TRANSFER, ASSIGNMENT, PLEDGE, HYPOTHECATION
ENCUMBRANCE OR OTHER DISPOSAL OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE
ARE SUBJECT TO THE TERMS OF THE GENERAL MARITIME CORPORATION 2001 STOCK
INCENTIVE PLAN AND A RESTRICTED STOCK GRANT AGREEMENT BETWEEN GENERAL MARITIME
CORPORATION AND THE HOLDER OF RECORD OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE.  NO TRANSFER OF THE SECURITIES REPRESENTED BY
THIS CERTIFICATE IN CONTRAVENTION OF SUCH PLAN AND RESTRICTED STOCK GRANT
AGREEMENT SHALL BE VALID OR EFFECTIVE. 
COPIES OF SUCH AGREEMENT MAY BE OBTAINED BY WRITTEN REQUEST MADE BY
THE HOLDER OF RECORD OF THE CERTIFICATE TO THE SECRETARY OF GENERAL MARITIME
CORPORATION.”

 

2

 

If the Restricted Stock is in book entry form, it
shall be subject to electronic coding or stop order indicating that such shares
of Restricted Stock are restricted by the terms of this Agreement and the
Plan.  Such legend, electronic coding or
stop order shall not be removed until such shares of Restricted Stock vest.

 

(b)           Reasonably promptly after the
Restricted Stock vests pursuant to Section 4 hereof, (i) in the case
of certificated shares, in exchange for the surrender to the Company of the
certificate evidencing the Restricted Stock, delivered to the Participant under
Section 8(a) hereof, and the certificates evidencing any other
securities received in respect of such shares, if any, the Company shall issue
and deliver to the Participant (or the Participant’s legal representative,
beneficiary or heir) a certificate evidencing the Restricted Stock and such
other securities, free of the legend provided in Section 8(a) hereof
and (ii) in the case of book entry shares, the Company shall cause to be
lifted and removed any electronic coding or stop order established pursuant to Section 8(a) hereof.

 

(c)           The Company may require as a condition
of the delivery of stock certificates or the lifting or removal of any
electronic coding or stop order with respect to book entry shares pursuant to Section 8(b) hereof
that the Participant remit to the Company an amount sufficient in the opinion
of the Company to satisfy any federal, state and other governmental tax
withholding requirements related to the vesting of the shares represented by
such certificate.  The Committee, in its
sole discretion, may permit the Participant to satisfy such obligation by delivering shares of Common Stock or by
directing the Company to withhold from delivery shares of Common Stock, in either case valued at their
Fair Market Value on the Vesting Date with fractional shares being settled in
cash.

 

(d)           The Participant shall not be deemed
for any purpose to be, or have rights as, a shareholder of the Company by
virtue of the grant of Restricted Stock, except to the extent a stock
certificate is issued therefor or an appropriate book entry is made on the
books of the transfer agent reflecting the issuance thereof pursuant to Section 8(a) hereof,
and then only from the date such certificate is issued or such book entry is
made.  Upon the issuance of a stock
certificate or the making of an appropriate book entry on the books of the
transfer agent, the Participant shall have the rights of a shareholder with
respect to the Restricted Stock, including the right to vote the shares,
subject to the restrictions on transferability and the forfeiture provisions,
as set forth in this Agreement.

 

9.             Securities Matters.  The Company shall be under no obligation to
effect the registration pursuant to the Securities Act of 1933, as amended (the
“1933 Act”) of any interests in the Plan or any shares of Common Stock to be
issued thereunder or to effect similar compliance under any state
laws.  The Company shall not be obligated to cause to be issued or
delivered any certificates or to cause to be made any book entries on the books
of the transfer agent evidencing shares of Common Stock pursuant hereto unless
and until the Company is advised by its counsel that the issuance and delivery
of such certificates or the making of such book entries is in compliance with
all applicable laws, regulations of governmental authority and the requirements
of any securities exchange on which shares of Common Stock are
traded.  The Committee may require, as a condition of the issuance
and delivery of certificates or the making of book entries on the books of the
transfer agent evidencing shares of Common Stock pursuant to the terms hereof,
that the recipient of such shares make such covenants, agreements and 

 

3

 

representations, and that
such certificates or book entries bear such legends, or be subject to
electronic coding or stop orders, as the Committee, in its sole discretion,
deems necessary or desirable.  The Participant specifically
understands and agrees that the shares of Common Stock, if and when issued, may
be “restricted securities,” as that term is defined in Rule 144 under the
1933 Act and, accordingly, the Participant may be required to hold the shares
indefinitely unless they are registered under such Act or an exemption from
such registration is available.

 

10.           Dividends, etc.  Any cash dividends or other property (but not
including securities) received by a Participant with respect to a share of
Restricted Stock shall not vest until the underlying share of Restricted Stock
vests, and, if the Committee or the Board of Directors so elects in their sole discretion,
shall be held by the Company or such other custodian as may be designated by
the Company until such dividends or other property vest.  Any such cash dividends or other property
shall be forfeited and returned to the Company in the event the underlying
share of Restricted Stock is forfeited, subject to Section 2.7(f) of
the Plan.  Any securities received by a
Participant with respect to a share of Restricted Stock as a result of any
dividend, recapitalization, merger, consolidation, combination, exchange of
shares or otherwise will not vest until such share of Restricted Stock vests
and shall be forfeited if such share of Restricted Stock is forfeited, subject
to Section 2.7(f) of the Plan. 
Unless the Committee otherwise determines, such securities shall bear
the legend or be subject to the electronic coding or stop order set forth in Section 8(a) hereof.

 

11.           Delays or Omissions.  No
delay or omission to exercise any right, power or remedy accruing to any party
hereto upon any breach or default of any party under this Agreement, shall
impair any such right, power or remedy of such party, nor shall it be construed
to be a waiver of any such breach or default, or an acquiescence therein, or of
or in any similar breach or default thereafter occurring, nor shall any waiver
of any single breach or default be deemed a waiver of any other breach or
default theretofore or thereafter occurring.  Any waiver, permit,
consent or approval of any kind or character on the part of any party of any
breach or default under this Agreement, or any waiver on the part of any party
or any provisions or conditions of this Agreement, must be in a writing signed
by such party and shall be effective only to the extent specifically set forth
in such writing.

 

12.           Right of Discharge Preserved.  Nothing in this Agreement shall confer upon
the Participant the right to continue as a member of the Board of Directors, or
affect any right which the Company may have to terminate such service.

 

13.           Integration.  This
Agreement contains the entire understanding of the parties with respect to its
subject matter.  There are no restrictions, agreements, promises,
representations, warranties, covenants or undertakings with respect to the
subject matter hereof other than those expressly set forth
herein.  This Agreement, including, without limitation, the Plan,
supersedes all prior agreements and understandings between the parties with
respect to its subject matter.

 

14.           Counterparts.  This
Agreement may be executed in two or more counterparts, each of which shall be
deemed an original, but all of which shall constitute one and the same
instrument.

 

4

 

15.           Governing Law.  This
Agreement shall be governed by and construed and enforced in accordance with
the laws of the State of New York, without regard to the provisions governing
conflict of laws.

 

16.           Obligation to Notify.  If the Participant makes the election
permitted under Section 83(b) of the Internal Revenue Code of 1986,
as amended (that is, an election to include in gross income in the year of
transfer the amounts specified in Section 83(b)), the Participant shall
notify the Company of such election within 10 days of filing notice of the
election with the Internal Revenue Service and shall within the same 10-day
period remit to the Company an amount sufficient in the opinion of the Company
to satisfy any federal, state and other governmental tax withholding
requirements related to such inclusion in Participant’s income. The Participant
should consult with his or her tax advisor to determine the tax consequences of
acquiring the Restricted Stock and the advantages and disadvantages of filing
the Section 83(b) election. 
The Participant acknowledges that it is his or her sole responsibility,
and not the Company’s, to file a timely election under Section 83(b), even
if the Participant requests the Company or its representatives to make this
filing on his or her behalf.

 

17.           Participant Acknowledgment.  The
Participant hereby acknowledges receipt of a copy of the Plan.  The
Participant hereby acknowledges that all decisions, determinations and
interpretations of the Committee in respect of the Plan, this Agreement and the
Restricted Stock shall be final and conclusive.

 

IN WITNESS WHEREOF, the
Company has caused this Agreement to be duly executed by its duly authorized
officer, and the Participant has hereunto signed this Agreement on his own
behalf, thereby representing that he has carefully read and understands this
Agreement and the Plan as of the day and year first written above.

 

 

	
   

  	
  GENERAL MARITIME
  CORPORATION

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
   

  
	
   

  	
  Name:

  	
  John C. Georgiopoulos

  
	
   

  	
  Title:

  	
  Executive Vice
  President, Treasurer and Secretary

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  WILLIAM J. CRABTREE

  

 

5

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