Document:

EXHIBIT 4.1

                           CERTIFICATE OF DESIGNATION
                      SERIES E CONVERTIBLE PREFERRED STOCK
                                       OF
                           IMMTECH INTERNATIONAL, INC.

      (Pursuant to Section 151 of the Delaware General Corporation Law)

            The following is a statement of the designations, preferences,
voting powers, qualifications, special or relative rights and privileges of the
Series E Convertible Preferred Stock of IMMTECH INTERNATIONAL, INC. ("Company").

      Article I. Designation and Amount. The shares of such series shall be
designated "Series E Convertible Preferred Stock" ("Series E Preferred Stock")
and the number of shares constituting such series shall be 167,000. The Company
previously authorized (i) 320,000 shares of its preferred stock pursuant to a
Certificate of Designation filed with the Secretary of State of the State of
Delaware on February 14, 2002 and has designated such shares therein as Series A
Convertible Preferred Stock ("Series A Preferred Stock"), (ii) 240,000 shares of
its preferred stock pursuant to a Certificate of Designation filed with the
Secretary of State of the State of Delaware on September 25, 2002 and has
designated such shares therein as Series B Convertible Preferred Stock ("Series
B Preferred Stock"), (iii) 160,000 shares of its preferred stock pursuant to a
Certificate of Designation filed with the Secretary of State of the State of
Delaware on June 6, 2003 and has designated such shares therein as Series C
Convertible Preferred Stock ("Series C Preferred Stock"), and (iv) 200,000
shares of its preferred stock pursuant to a Certificate of Designation filed
with the Secretary of State of the State of Delaware on January 15, 2004 and has
designated such shares therein as Series D Convertible Preferred Stock ("Series
D Preferred Stock", and collectively with the Series A Preferred Stock, Series B
Preferred Stock and Series C Preferred Stock, the "Outstanding Preferred
Stock").

      Notwithstanding anything to the contrary contained herein, in the
Certificate of Designation Series A Convertible Preferred Stock ("Series A
Certificate of Designation"), in the Certificate of Designation Series B
Convertible Preferred Stock ("Series B Certificate of Designation"), in the
Certificate of Designation Series C Convertible Preferred Stock ("Series C
Certificate of Designation"), or in the Certificate of Designation Series D
Convertible Preferred Stock ("Series D Certificate of Designation", and
collectively with the Series A Certificate of Designation, Series B Certificate
of Designation and Series C Certificate of Designation, the "Outstanding
Certificates of Designation") except as may be specifically provided for herein,
in the Outstanding Certificates of Designation or waived or consented to by the
holders of Outstanding Preferred Stock, the Series A Preferred Stock, Series B
Preferred Stock, Series C Preferred Stock, Series D Preferred Stock and this
Series E Preferred Stock are to be pari passu in all respects as to rights of
payment and distribution (whether in cash, in kind or in other property or
securities), whether by way of dividend, upon liquidation, or otherwise, and all
such payments and distributions shall be made to the Outstanding Preferred Stock
and Series E Preferred Stock pari passu and simultaneously by the Company. To
the extent any payment is insufficient to fully discharge the obligations of the
Company to Series E Preferred Stock hereunder and under the Outstanding
Certificates of Designation, such payment will be made pro rata between each
series by multiplying same by a fraction, the numerator of which is the amount
of the payment due such series, and the denominator of which is the total
payment due the Outstanding Preferred Stock and Series E Preferred Stock.

      Article II. Dividends. The holders of Series E Preferred Stock ("Series E
Preferred Stockholders") shall be entitled to receive semi-annually, on April 15
and October 15 of each year until such Series E Preferred Stock is either
converted or redeemed pursuant to this Certificate of Designation, dividends at
the rate of 6.0% per annum on the stated value of $25.00 per share. All
dividends declared upon the Series E Preferred Stock shall be declared pro rata
per share and shall accrue daily through the day immediately before the date of
conversion or redemption thereof. At the Company's option, dividends may be paid
in cash or Common Stock, or any combination thereof. In the event dividends are
paid in Common Stock, the value of the Common Stock for this purpose is to be
the 10-day volume-weighted average of the closing sale price of the Company's
Common Stock as reported by the primary stock exchange on which such stock is
listed or traded, or if not so listed or traded, then as determined in good
faith by the Board of Directors ("Common Stock Price"). In no event, however,
shall the Company pay dividends in Common Stock to the extent that, when
aggregated together with the shares of Common Stock issued or issuable upon
conversion of the Series E Preferred Stock into Common Stock, the Company shall
issue shares of Common Stock in excess of 19.99% of the number of shares of
Common Stock outstanding on the date of filing of this Certificate of
Designation.

      Article III. Liquidation, Dissolution or Winding Up. (a) In the event of
any voluntary or involuntary liquidation, dissolution or winding up of the
Company, before any distribution or payment is made to any holders of Common
Stock or any other class or series of capital stock of the Company designated to
be junior to the Series E Preferred Stock ("Junior Stock") and subject to the
liquidation rights and preferences of any class or series of preferred stock
designated in the future to be senior to ("Senior Stock"), or on a parity with,
the Series E Preferred Stock with respect to liquidation preferences, the
holders of each share of Series E Preferred Stock shall be entitled, pari passu
with each other and with the holders of each share of Outstanding Preferred
Stock as to right of payment, to be paid first out of the assets of the Company
available for distribution to holders of the Company's capital stock of all
classes whether such assets are capital, surplus or earnings ("Available
Assets"), an amount equal to $25.00 per share plus all accrued but unpaid
dividends ("Liquidation Price"). If, upon any such liquidation, dissolution or
winding up of the Company, the remaining assets of the Company available for
distribution to its stockholders after payment in full of amounts required to be
paid or distributed to holders of Senior Stock shall be insufficient to pay the
holders of shares of Series E Preferred Stock the full amount to which they
shall be entitled, the holders of shares of Series E Preferred Stock, together
with the holders of Outstanding Preferred Stock and any class of stock ranking
on liquidation on a parity with the Series E Preferred Stock, shall share
ratably in any distribution of the remaining assets and funds of the Company in
proportion to the respective amounts which would otherwise be payable in respect
to the shares held by them upon such distribution if all amounts payable on or
with respect to said shares were paid in full.

(b) After the payment of all preferential amounts required to be paid to the
holders of Senior Stock and Series E Preferred Stock and any other series of
preferred stock upon the dissolution, liquidation or winding up of the Company,
the holders of shares of Common Stock then outstanding shall be entitled to
receive the remaining assets and funds of the Company available for distribution
to its stockholders.

(c) The Liquidation Price set forth in this Article III shall be subject to
equitable adjustment whenever there shall occur a stock split, stock dividend,
combination, recapitalization, reclassification or other similar event involving
a change in the Series E Preferred Stock.

      Article IV. Voting. (a) Each issued and outstanding share of Series E
Preferred Stock shall be entitled to 3.5511 times the number of votes as each
share of Common Stock is entitled to vote at each meeting of stockholders of the
Company with respect to any and all matters presented to the stockholders of the
Company for their action or consideration (subject to adjustment whenever there
shall occur a stock split, stock dividend, combination, recapitalization,
reclassification or other similar event involving a change in the Series E
Preferred Stock). Except as provided by law or by the provisions establishing
any other series of preferred stock, Series E Preferred Stockholders and holders
of any other outstanding preferred stock shall vote together with the holders of
Common Stock as a single class.

(b) The Company shall not amend, alter or repeal the preferences, special rights
or other powers of the Series E Preferred Stock so as to adversely affect the
Series E Preferred Stock, without the written consent or affirmative vote of the
holders of at least a majority of the then outstanding aggregate number of
shares of such affected Series E Preferred Stock, given in writing or by vote at
a meeting, consenting or voting (as the case may be) separately as a class;
provided; however; the Company may at any time without the vote or consent of
the Series E Preferred Stockholders or any other stockholder amend this Series E
Certificate of Designation (i) as provided in the Series E Subscription
Agreement or (ii) to increase or reduce the number of shares designated
hereunder so long as any reduction does not result in the designation of less
Series E Preferred Stock than is issued and outstanding at the time of the
reduction.

      Article V. Conversion. The number of shares of Common Stock to which a
holder of Series E Preferred Stock shall be entitled to receive upon conversion
shall be the product obtained by multiplying the Conversion Rate (as hereinafter
defined) by the number of shares of Series E Preferred Stock being converted at
any time. The conversion rate in effect at any time for the Series E Preferred
Stock ("Conversion Rate") shall be the quotient obtained by dividing $25.00 plus
any accrued and unpaid dividends by the Conversion Price. The conversion price
in effect from time to time shall be $7.04 per share ("Conversion Price"),
subject to adjustment whenever there shall occur a stock split, stock dividend,
combination, recapitalization, reclassification or other similar event involving
a change in the Series E Preferred Stock.

(a) Optional Conversion. Each share of Series E Preferred Stock may be converted
at any time, at the option of the holder thereof, in the manner hereinafter
provided, into fully-paid and nonassessable shares of Common Stock, provided,
however, that on any redemption of any Series E Preferred Stock or any
liquidation of the Company, the right of conversion shall terminate at the close
of business 5 business days preceding the date fixed for such redemption or for
the payment of any amounts distributable on liquidation to the Series E
Preferred Stockholders.

      1. In order to exercise an optional conversion, a Series E Preferred
      Stockholder shall surrender a certificate or certificates representing the
      shares to be converted to the transfer agent for the Series E Preferred
      Stock (or, if no transfer agent be at the time appointed, then the Company
      at its principal office), and shall give written notice to the Company
      that the holder elects to convert the Series E Preferred Stock represented
      by such certificates, or any number thereof. If so required by the
      Company, certificates surrendered for conversion shall be duly endorsed or
      accompanied by duly executed written instrument or instruments of
      transfer, in form satisfactory to the Company. The date of receipt by the
      transfer agent (or by the Company if the Company serves as its own
      transfer agent) of the certificates and the notice shall be the Conversion
      Date. As soon as practicable after receipt of such notice and the
      surrender of the certificate or certificates for Series E Preferred Stock,
      the Company shall cause to be issued and delivered to such holder a
      certificate or certificates for the number of full shares of Common Stock
      issuable on such conversion in accordance with the provisions hereof and
      cash in respect of any fraction of a share of Common Stock otherwise
      issuable upon such conversion.

(b) Mandatory Conversion. The Company may, at any time after December 1, 2006,
upon notice as below provided, require that any or all outstanding Series E
Preferred Stock be converted into Common Stock in the manner hereinafter
provided if the Common Stock into which the Series E Preferred Stock is
convertible is registered pursuant to an effective registration statement under
the Securities Act of 1933, as amended, by delivery to the Series E Preferred
Stockholders, for each share of Series E Preferred Stock converted, (i) the
number of shares of Common Stock determined by dividing the Liquidation Price by
the Conversion Price, if the closing sale price for the Company's common stock
exceeds 150% of the applicable Conversion Price for 20 out of 30 consecutive
"trading days" (days the principal exchange on which the Common Stock is listed
or traded is open for business or, if the Common Stock is no longer listed or
traded on an exchange, business days) within 180 days prior to notice of
conversion or (ii), if the requirements of (i) are not met, the number of shares
of Common Stock determined by dividing 110% of the Liquidation Price by the
Conversion Price.

      1. In order to exercise a mandatory conversion, the Company must provide
      all Series E Preferred Stockholders notice of the conversion at least 30
      days prior to the Conversion Date, such notice to include the number of
      shares to be converted and instructions for surrender of the certificate
      or certificates representing the Series E Preferred Stock. Upon surrender
      of the certificates to the transfer agent, the Company shall cause to be
      issued and delivered to such holder a certificate or certificates for the
      number of full shares of Common Stock issuable on such conversion in
      accordance with the provisions hereof and cash in respect of any fraction
      of a share of Common Stock otherwise issuable upon such conversion. The
      Company shall not be obligated to issue such certificates unless
      certificates evidencing the shares of Series E Preferred Stock being
      converted are either delivered to the Company or any such transfer agent,
      or the holder notifies the Company that such certificates have been lost,
      stolen or destroyed and executes an agreement satisfactory to the Company
      to indemnify the Company from any loss incurred by it in connection
      therewith.

      2. In the event the Company does not redeem all outstanding shares of
      Series E Preferred Stock in a mandatory conversion, the Company shall
      redeem pro-rata from each Series E Preferred Stockholder such number of
      shares determined by dividing the number of shares to be redeemed by the
      number of shares of Series E Preferred Stock then outstanding, multiplied
      by the number of shares held by each Series E Preferred Stockholder.

(c) Term. The Company will, on the third anniversary of this Certificate of
Designation, at the Company's election, (1) redeem the Series E Stock plus any
accrued and unpaid interest for cash, (2) convert the Series E Stock and any
accrued and unpaid interest into Common Stock valued as set forth in (b)(1)
above, or (3) redeem and convert the Series E Stock in any combination of (1)
and (2) above.

(d) Redemption. Each holder of Series E Stock shall have the right, but not the
obligation, to require the Company to redeem for cash, any or all of such
holder's Series E Stock plus accrued and unpaid interest, so long as any of the
following events occur and remain uncured (i) the Company delays the audit of
its financial statements beyond 180 days after the end of the Company's fiscal
year (excluding for causes beyond the Company's control, for so long as such
cause remains in effect), (ii) failure to file Sarbanes-Oxley or equivalent
forms when required of it by the rules and regulations of the Exchange Act of
1934, as amended, or (iii) the Company's Common Stock is delisted from the
American Stock Exchange ("AMEX") (unless the Company's Common Stock is listed
within sixty days of such delisting on any of the AMEX, New York Stock Exchange
or the NASDAQ market).

(e) Fractional Shares. The Company shall not issue fractions of shares of Common
Stock upon conversion of Series E Preferred Stock or scrip in lieu thereof. If
any fraction of a share of Common Stock would, except for the provisions of this
Article V(e), be issuable upon conversion of any Series E Preferred Stock, the
Company shall in lieu thereof pay to the person entitled thereto an amount in
cash equal to the current value of such fraction, calculated to the nearest
one-hundredth (1/100) of a share, to be computed at the Common Stock Price on
the date of conversion.

(f) Reservation of Shares. The Company shall at all times reserve out of its
authorized but unissued shares of Common Stock such number of shares of Common
Stock as shall from time to time be sufficient to permit the conversion of all
of the Series E Preferred Stock then outstanding, and if at any time the number
of authorized but unissued shares of Common Stock shall not be sufficient to
effect the conversion of all then outstanding shares of Series E Preferred
Stock, the Company shall take such action as may be necessary to increase its
authorized but unissued shares of Common Stock to such number of shares as shall
be sufficient for such purpose. All shares of Common Stock issued upon due
conversion of shares of Series E Preferred Stock shall be validly issued, fully
paid and non-assessable.

(g) Rights Upon Conversion. All shares of Series E Preferred Stock which shall
have been surrendered for conversion as herein provided shall no longer be
deemed to be outstanding and all rights with respect to such shares, including
the rights, if any, to receive notices and to vote, shall forthwith cease and
terminate except only the right of the holder thereof to receive shares of
Common Stock in exchange therefor and payment of any accrued and unpaid
dividends thereon.
<PAGE>

            IN WITNESS WHEREOF, Immtech International, Inc. has caused this
Certificate of Designation Series E Convertible Preferred Stock to be duly
executed by its President and Chief Executive Officer this 13th day of December,
2005.

                                      IMMTECH INTERNATIONAL, INC.

                                      By: /s/ T. Stephen Thompson
                                          -------------------------------------
                                          T. Stephen Thompson
                                          President and Chief Executive
                                          OfficerCERTIFICATE OF CORRECTION FILED TO CORRECT
              THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                           IMMTECH INTERNATIONAL, INC.

            IMMTECH INTERNATIONAL, INC., (hereinafter called the "Corporation"),
a corporation organized and existing under and by virtue of the General
Corporation Law of the State of Delaware, does hereby certify:

1.    The name of the corporation is "Immtech International, Inc."

2.    That an Amended and Restated Certificate of Incorporation (the
      "Certificate") was filed by the Secretary of State of Delaware on June 14,
      2004 and that said Certificate requires correction as permitted by Section
      103 of the General Corporation Law of the State of Delaware.

3.    The inaccuracy or defect of said certificate to be corrected is as
      follows: in the Certificate, Article Forth, Section 3(9), the Company did
      not reference the series of preferred stock outstanding as of the date of
      the Certificate.

4.    Section 3(9) of Article Fourth of the Certificate is hereby corrected as
      follows, to add the last paragraph:

            "Section 3 . . .

            (i) any other such rights and preferences as are not inconsistent
            with the Delaware General Corporation Law.

            No holder of any share of any series of Preferred Stock shall be
            entitled to vote for the election of directors or in respect of any
            other matter except as may be required by the Delaware General
            Corporation Law, as amended, or as is permitted by the resolution or
            resolutions adopted by the Board of Directors authorizing the issue
            of such series of Preferred Stock.

            Except as required by the Act, amendments to or modifications of the
            rights and preferences of any series of Preferred Stock shall be
            approved by the vote of the shares of such series of Preferred Stock
            at a duly called meeting of such series or by the written consent of
            holders of such series of Preferred Stock holding a majority of the
            outstanding shares of such series.

            As of the date of this Amended and Restated Certificate of
            Incorporation, the Board of Directors has authorized and the
            Corporation has so designated (as the same may from time-to-time be
            amended): (i) 320,000 shares of its preferred stock pursuant to a
            Certificate of Designation filed with the Secretary of State of the
            State of Delaware on February 14, 2002 and has designated such
            shares therein as Series A Convertible Preferred Stock ("Series A
            Preferred Stock"), (ii) 240,000 shares of its preferred stock
            pursuant to a Certificate of Designation filed with the Secretary of
            State of the State of Delaware on September 25, 2002 and has
            designated such shares therein as Series B Convertible Preferred
            Stock ("Series B Preferred Stock"), (iii) 160,000 shares of its
            preferred stock pursuant to a Certificate of Designation filed with
            the Secretary of State of the State of Delaware on June 6, 2003 and
            has designated such shares therein as Series C Convertible Preferred
            Stock ("Series C Preferred Stock"), and (iv) 200,000 shares of its
            preferred stock pursuant to a Certificate of Designation filed with
            the Secretary of State of the State of Delaware on January 15, 2004
            and has designated such shares therein as Series D Convertible
            Preferred Stock ("Series D Preferred Stock", and collectively with
            the Series A Preferred Stock, Series B Preferred Stock and Series C
            Preferred Stock, the "Outstanding Preferred Stock"). The Outstanding
            Preferred Stock remains designated and authorized."

5.    A copy of the Certificate, as hereby corrected, is attached hereto as
      Appendix I.

<PAGE>

            IN WITNESS WHEREOF, said Corporation has caused this Certificate of
Correction to be filed this 14th day of December, 2005.

                                       By:  /s/  T. Stephen Thompson
                                          --------------------------------------
                                          T. Stephen Thompson
                                          Chief Executive Officer

<PAGE>

                                   APPENDIX I

                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                           IMMTECH INTERNATIONAL, INC.

            The following Amendment and Restatement of the Certificate of
Incorporation of Immtech International, Inc. (the "Corporation") was adopted on
January 7, 2004, in the manner indicated below.

            In accordance with Section 242(b) and Section 245 of the General
Corporation Law of the State of Delaware, this Restated and Amended Certificate
of Incorporation was declared advisable and adopted by the Board of Directors of
the Corporation on November 4, 2003, and was approved by the consent of the
shareholders of the Corporation at the annual meeting of the stockholders on
January 7, 2004.

            The original Certificate of Incorporation of the Corporation was
filed with the Secretary of State of Delaware on December 18, 1992.

            The Certificate of Incorporation, as amended, of Immtech
International, Inc., is amended and restated as follows:

                                  ARTICLE FIRST

            The name of the Corporation is Immtech International, Inc.

                                 ARTICLE SECOND

            The name and address of the Corporation's registered office in the
State of Delaware is Vanguard Corporate Services, Ltd. located at 15 East North
Street, Dover, DE 19901, in the County of Kent, or such other name and address
as the Board of Directors of the Corporation may from time to time select.

                                 ARTICLE THIRD

            The nature of the business or purposes to be conducted or promoted
is to engage in any lawful act or activity for which corporations may be
organized under the General Corporation Law of the State of Delaware.

                                 ARTICLE FOURTH

            Section 1 Authorized Capital Stock. The total number of shares which
the Corporation shall have the authority to issue shall be 105,000,000 shares,
of which 100,000,000 shares shall be Common Stock, $0.01 par value, and
5,000,000 shares shall be Preferred Stock, $0.01 par value.

            Section 2 Common Stock. The Board of Directors is hereby authorized
to cause shares of Common Stock to be issued from time to time for such
consideration as may be fixed from time to time by the Board of Directors, or by
way of stock split pro rata to the holders of the Common Stock. The Board of
Directors may also determine the proportion of the proceeds received from the
sale of such stock which shall be credited upon the books of the Corporation to
capital or capital surplus.

            Each share of the Common Stock shall be equal in all respects to
every other share of the Common Stock. Subject to any special voting rights of
the holders of Preferred Stock fixed by or pursuant to the provisions of Section
3 of this Article Fourth, the shares of Common Stock shall entitle the holders
thereof to one vote for each share upon all matters upon which stockholders have
the right to vote.

            Unless otherwise required by the Act, the holders of shares of
Common Stock shall not be entitled to vote on any amendments to or modifications
of the rights and preferences of any class or series of shares of Preferred
Stock of the Corporation.

            No holder of shares of Common Stock shall be entitled as such as a
matter of right to subscribe for or purchase any part of any new or additional
issues of stock, or securities convertible into stock, of any class whatsoever,
whether now or hereafter authorized, and whether issued for cash, property,
services or otherwise.

            After the requirements with respect to preferential dividends on
Preferred Stock (fixed by or pursuant to the provisions of Section 3 of this
Article Fourth), if any, shall have been met and after the Corporation shall
have complied with all the requirements, if any, with respect to the setting
aside of sums as sinking funds or redemption or purchase accounts (fixed by or
pursuant to the provisions of Section 3 of this Article Fourth) and subject
further to any other conditions which may be fixed by or pursuant to the
provisions of Section 3 of this Article Fourth, then, but not otherwise, the
holders of Common Stock shall be entitled to receive dividends, if any, as may
be declared from time to time by the Board of Directors.

            After distribution in full of the preferential amount (fixed by or
pursuant to the provisions of Section 3 of this Article Fourth), if any, to be
distributed to the holders of Preferred Stock in the event of voluntary or
involuntary liquidation, distribution or sale of assets, dissolution or winding
up of the Corporation, the holders of the Common Stock shall be entitled to
receive all the remaining assets of the Corporation, tangible and intangible, of
whatever kind available for distribution to stockholders, ratably in proportion
to the number of shares of Common Stock held by each.

            Section 3 Preferred Stock. Shares of Preferred Stock may be divided
into and issued in such series, on such terms and for such consideration as may
from time to time be determined by the Board of Directors of the Corporation.
Each series shall be so designated as to distinguish the shares thereof from the
shares of all other series and classes. All shares of Preferred Stock shall be
identical, except as to variations between different series in the relative
rights and preferences as permitted or contemplated by the next succeeding
sentence. Authority is hereby vested in the Board of Directors of the
Corporation to establish out of shares of Preferred Stock which are authorized
and unissued from time to time one or more series thereof and to fix and
determine the following relative rights and preferences of shares of each such
series:

            (1) the distinctive designation of, and the number of shares which
shall constitute, the series and the "stated value" or "nominal value," if any,
thereof;

            (2) the rate of dividend applicable to shares of such series;

            (3) the price at and the terms and conditions on which shares of
such series may be redeemed;

            (4) the amount payable upon shares of such series in the event of
the involuntary liquidation of the Corporation;

            (5) the amount payable upon shares of such series in the event of
the voluntary liquidation of the Corporation;

            (6) sinking fund provisions for the redemption or purchase of shares
of such series;

            (7) the terms and conditions on which shares of such series may be
converted, if such shares are issued with the privilege of conversion;

            (8) the voting powers, if any, of the holders of shares of the
series, which may, without limiting the generality of the foregoing, include (i)
the right to one or less than one vote per share on any or all matters voted
upon by the stockholders and (ii) the right to vote, as a series by itself or
together with other series of Preferred Stock or together with all series of
Preferred Stock as a class, upon such matters, under such circumstances and upon
such conditions as the Board of Directors may fix, including, without
limitation, the right, voting as a series by itself or together with other
series of Preferred Stock or together with all series of Preferred Stock as a
class, to elect one or more directors of the Corporation in the event there
shall have been a failure to pay dividends on any one or more series of
Preferred Stock or under such other circumstances and upon such conditions as
the Board of Directors may determine; provided, however, that in no event shall
a share of Preferred Stock have more than one vote; and

            (9) any other such rights and preferences as are not inconsistent
with the Delaware General Corporation Law.

            No holder of any share of any series of Preferred Stock shall be
entitled to vote for the election of directors or in respect of any other matter
except as may be required by the Delaware General Corporation Law, as amended,
or as is permitted by the resolution or resolutions adopted by the Board of
Directors authorizing the issue of such series of Preferred Stock.

            Except as required by the Act, amendments to or modifications of the
rights and preferences of any series of Preferred Stock shall be approved by the
vote of the shares of such series of Preferred Stock at a duly called meeting of
such series or by the written consent of holders of such series of Preferred
Stock holding a majority of the outstanding shares of such series.

            As of the date of this Amended and Restated Certificate of
Incorporation, the Board of Directors has authorized and the Corporation has so
designated (as the same may from time-to-time be amended): (i) 320,000 shares of
its preferred stock pursuant to a Certificate of Designation filed with the
Secretary of State of the State of Delaware on February 14, 2002 and has
designated such shares therein as Series A Convertible Preferred Stock ("Series
A Preferred Stock"), (ii) 240,000 shares of its preferred stock pursuant to a
Certificate of Designation filed with the Secretary of State of the State of
Delaware on September 25, 2002 and has designated such shares therein as Series
B Convertible Preferred Stock ("Series B Preferred Stock"), (iii) 160,000 shares
of its preferred stock pursuant to a Certificate of Designation filed with the
Secretary of State of the State of Delaware on June 6, 2003 and has designated
such shares therein as Series C Convertible Preferred Stock ("Series C Preferred
Stock"), and (iv) 200,000 shares of its preferred stock pursuant to a
Certificate of Designation filed with the Secretary of State of the State of
Delaware on January 15, 2004 and has designated such shares therein as Series D
Convertible Preferred Stock ("Series D Preferred Stock", and collectively with
the Series A Preferred Stock, Series B Preferred Stock and Series C Preferred
Stock, the "Outstanding Preferred Stock"). The Outstanding Preferred Stock
remains designated and authorized.

            Section 4 Other Provisions. (1) The relative powers, preferences,
and rights of each series of Preferred Stock shall, in each case, be as fixed
from time to time by the Board of Directors in the resolution or resolutions
adopted pursuant to authority granted in Section 3 of this Article Fourth, and
the consent by class or series vote or otherwise, of the holders of the
Preferred Stock or such of the series of the Preferred Stock as are from time to
time outstanding shall not be required for the issuance by the Board of
Directors of any other series of Preferred Stock whether the powers, preferences
and rights of such other series shall be fixed by the Board of Directors as
senior to, or on a parity with, powers, preferences and rights of such
outstanding series, or any of them; provided, however, that the Board of
Directors may provide in such resolution or resolutions adopted with respect to
any series of Preferred Stock that the consent of the holders of a majority (or
such greater proportion as shall be therein fixed) of the outstanding shares of
such series voting thereon shall be required for the issuance of any or all
other series of Preferred Stock.

            (2) Subject to the provisions of Subsection 1 of this Section 4,
shares of any series of Preferred Stock may be issued from time to time as the
Board of Directors shall determine and on such terms and for such consideration
as shall be fixed by the Board of Directors.

            (3) Common Stock may be issued from time to time as the Board of
Directors shall determine and on such terms and for such consideration as shall
be fixed by the Board of Directors.

            (4) No holder of any of the shares of any class or series of shares
or securities convertible into such shares of any class or series of shares, or
of options, warrants or other rights to purchase or acquire shares of any class
or series of shares or of other securities of the Corporation shall have any
preemptive right to purchase, acquire, subscribe for any unissued shares of any
class or series or any additional shares of any class or series to be issued by
reason of any increase of the authorized capital stock of the Corporation of any
class or series, or bonds, certificate of indebtedness, debenture or other
securities convertible into or exchangeable for shares of any class or series,
or carrying any right to purchase or acquire shares of any class or series, but
any such unissued shares, additional authorized issue of shares of any class or
series of shares or securities convertible into or exchangeable for shares, or
carrying any right to purchase or acquire shares, may be issued and disposed of
pursuant to resolution of the Board of Directors to such persons, firms,
corporations or associations, and upon such terms, as may be deemed advisable by
the Board of Directors in the exercise of its sole discretion.

            (5) The Corporation reserves the right to increase or decrease its
authorized capital stock, or any class or series thereof or to reclassify the
same and to amend, alter, change or repeal any provision contained in this
Amended and Restated Certificate of Incorporation or in any amendment hereto, in
the manner now or hereafter prescribed by law, but subject to such conditions
and limitations as are hereinbefore prescribed, and all rights conferred upon
stockholders in this Amended and Restated Certificate of Incorporation or any
amendment thereto, are granted subject to this reservation.

            Each share of Common Stock which was issued and outstanding before
June 30, 1998 was converted into 0.645260 issued and outstanding share of Common
Stock, and in lieu of any fractional shares created by the above-provide-for
reverse stock split, the Corporation paid to the holders thereof the fair value
of such fractional shares in cash.

            Each share of Series A Preferred which was issued and outstanding
before June 30, 1998 was reclassified into 0.645260 issued and outstanding share
of Common Stock (after giving effect to the above-provided-for-reverse stock
split), and in lieu of any fractional shares created by the above-provided-for
reclassification, the Corporation paid to the holders thereof the fair value of
such fractional shares in cash.

            Each share of Series A Preferred which was authorized but not
outstanding prior to June 30, 1998, was eliminated.

            Each share of Series B Preferred which was issued and outstanding
before June 30, 1998, was reclassified into 0.770086 issued and outstanding
share of Common Stock (after giving effect to the above-provided-for reverse
stock split), and in lieu of any fractional shares created by the
above-provided-for reclassification, the Corporation paid to the holders thereof
the fair value of such fractional shares in cash.

            Each share of Series B Preferred which was authorized but not
outstanding prior to June 30, 1998, was eliminated.

            Each share of Common Stock which was issued and outstanding prior to
February 2, 1999, was converted into 0.5 issued and outstanding share of Common
Stock, and in lieu of any fractional shares created by the above-provided-for
reverse stock split, the Corporation paid to the holders thereof the fair value
of such fractional shares in cash. The above-provided-for reverse stock split
did not change the total number of authorized shares of Common Stock or the par
value of Common Stock.

                                  ARTICLE FIFTH

            The board of directors of the Corporation shall consist of not more
than seven members.

                                 ARTICLE SIXTH

            The Corporation is to have perpetual existence.

                                ARTICLE SEVENTH

            In furtherance and not in limitation of the powers conferred by
statute, the board of directors of the Corporation is expressly authorized to
make, alter or repeal the bylaws of the Corporation.

                                 ARTICLE EIGHTH

            Meetings of stockholders may be held within or without the State of
Delaware, as the bylaws of the Corporation may provide. The books of the
Corporation may be kept outside the State of Delaware at such place or places as
may be designated from time to time by the board of directors or in the bylaws
of the Corporation. Election of directors need not be by written ballot unless
the bylaws of the Corporation so provide.

                                 ARTICLE NINTH

            To the fullest extent permitted by the laws of the state of Delaware
as the same exist or may hereafter be amended, a director of this Corporation
shall not be personally liable to this Corporation or its stockholders for
monetary damages for breach of fiduciary duty as a director. If the laws of the
state of Delaware are amended, after approval by the stockholders of this
provision, to authorize corporate action further eliminating or limiting the
personal liability of directors, then the liability of a director of this
Corporation shall be eliminated or limited to the fullest extend permitted by
the laws of the state of Delaware, as so amended. Any repeal or modification of
this Article NINTH by the stockholders of this Corporation shall not adversely
affect any right or protection of a director of this Corporation existing at the
time of such repeal or modification or with respect to events occurring prior to
such time.

                                 ARTICLE TENTH

            (A) This Corporation shall indemnify any person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative or
investigative (other than an action by or in the right of this Corporation), by
reason of the fact that such person is or was a director or officer of this
Corporation, or is or was serving at the request of this Corporation as a
director or officer of another corporation, partnership, joint venture, trust or
other enterprise, against expenses (including attorneys' fees), judgments, fines
and amounts paid in settlement actually and reasonably incurred by such person
in connection with such act, suit or proceeding if the person acted in good
faith and in a manner such person reasonably believed to be in or not opposed to
the best interests of this Corporation, and with respect to any criminal action
or proceeding, had no reasonable cause to believe such person's conduct was
unlawful. The termination of any action, suit or proceeding by judgment, order,
settlement, conviction, or upon a plea of nolo contendere or its equivalent,
shall not, of itself, create a presumption that the person did not act in good
faith and in a manner which such person reasonably believed to be in or not
opposed to the best interests of this Corporation, and, with respect to any
criminal action or proceeding, had reasonable cause to believe that his conduct
was unlawful.

            (B) This Corporation shall indemnify any person who was or is a
party or is threatened to be made a party to any threatened, pending or
completed action or suit by or in the right of this Corporation to procure a
judgment in its favor by reason of the fact that such person is or was a
director or officer of this Corporation, or is or was serving at the request of
this Corporation as a director or officer of another Corporation, partnership,
joint venture, trust or other enterprise, against expenses (including attorney's
fees) actually and reasonably incurred by him in connection with the defense or
settlement of such action or suit if he acted in good faith and a manner he
reasonably believed to be in or not opposed to the best interests of this
Corporation and except that no indemnification shall be made in respect of any
claim, issue or matter as to which such person shall have been adjudged to be
liable to this Corporation unless and only to the extent that the Delaware Court
of Chancery or the court in which such action or suit was brought shall
determine upon application that, despite the adjudication of liability but in
view of all the circumstances of the case, such person is fairly and reasonably
entitled to indemnity for such expenses which the Delaware Court of Chancery or
such other court shall deem proper. Any indemnification under this paragraph and
paragraph (A) of this Article TENTH (unless ordered by a court) shall be made by
the Corporation only as authorized in the specific case upon a determination
that the indemnification of the director, officer, employee or agent is proper
in the circumstances because he has met the applicable standard of conduct set
forth in paragraph A and this paragraph B of Article TENTH. Such determination
shall be made (1) by a majority vote of the directors who are not parties to
such action, suit or proceeding, even though less than a quorum, or (2) by a
committee of such directors designated by majority vote of such directors, even
though less than a quorum, or (3) if there are no such directors, or if such
directors so direct, by independent legal counsel in a written opinion, or (4)
by the stockholders.

            (C) Expenses incurred by a director or officer in defending a
civil or criminal action, suit or proceeding shall be paid by the Corporation in
advance of the final disposition of such action, suit or proceeding upon the
receipt of an invoice of the expenses and an undertaking by or on behalf of such
person to repay such amount if it shall ultimately be determined that he is not
entitled to be indemnified by the Corporation as authorized by the General
Corporation Law of the State of Delaware. Expenses incurred by other persons may
be so paid upon such terms and conditions, if any, as the board of directors
deems appropriate.

            (D) In addition to the right of indemnification provided for in
this article TENTH, this Corporation may, to the fullest and broadest extent
permitted by applicable law, including, without limitation, the General
Corporation Law of the State of Delaware as it may be amended from time to time,
indemnify all other persons, including employees and agents of the Corporation
or persons serving at the request of this Corporation as an employee or agent of
another Corporation, partnership, joint venture, trust or other enterprise, whom
it may indemnify pursuant thereto.

            (E) The right of indemnification provided by this Article TENTH
shall apply as to action by any person in his or her official capacity and as to
action in another capacity while holding such office and shall continue as a to
a person who has ceased to be a director, officer, employee or agent and shall
inure to the benefit of the heirs, executors and administrators of such a
person.

            (F) The right of indemnification provided by this Article TENTH
shall not be deemed exclusive of any other rights to which those seeking
indemnification may be entitled under any bylaw, agreement, vote of stockholders
or disinterested directors or otherwise, both as to action in his official
capacity and as to action in another capacity while holding such office, and the
Corporation may provide additional indemnity and rights to its directors,
officers, employees or agents in excess of the indemnification and advancement
otherwise permitted by the General Corporation Law of the State of Delaware, and
subject only to the limits created by applicable Delaware law with respect to
actions for breach of duty to the corporation, its stockholders and others. The
right of indemnification provided herein shall continue as to a person who has
ceased to be a director, officer, employee or agent and shall inure to the
benefit of the heirs, executors and administrators of such a person.

            (G) The right of indemnification provided by this Article TENTH
shall be deemed to be a contract between this Corporation and each director,
officer, employee or agent of this Corporation who serves in such capacity, both
as to action in his official capacity and as to action in another capacity while
holding such office, at any time while this Article TENTH and the relevant
provisions of the General Corporation Law of the State of Delaware and other
applicable law, if any, are in effect, and repeal or modification thereof shall
not affect any rights or obligations then existing with respect to any state of
facts then or theretofore existing or any action, suit or proceeding theretofore
or thereafter brought or threatened based in whole or in part upon any such
state of facts.

            (H) Notwithstanding any provision of this Article TENTH to the
contrary, this Corporation may, but shall not be obligated to, purchase and
maintain insurance on behalf of any person who is or was a director, officer,
employee or agent of this Corporation, or is or was serving at the request of
this Corporation as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust or other enterprise against any
liability asserted against him and incurred by him in any such capacity, or
arising out of his or her status as such, whether or not this Corporation would
have the power to indemnify him or her against such liability.

            (I) For purposes of this Article TENTH, references to "other
enterprises" shall include employee benefit plans; references to "fines" shall
include any excise taxes assessed on a person with respect to an employee
benefit plan; and references to "serving at the request of the corporation"
shall include any service as a director, officer, employee or agent of the
Corporation which imposes duties on, or involves services by, such director,
officer, employee or agent with respect to an employee benefit plan, its
participants or beneficiaries, and a person who acted in good faith and in a
manner such person reasonably believed to be in the interest of the participants
and beneficiaries of an employee benefit plan shall be deemed to have acted in a
manner such person reasonably believed to be in the interest of the participants
and beneficiaries of an employee benefit plan shall be deemed to have acted in a
manner "not opposed to the best interests of the corporation" as referred to in
this Article TENTH.

                                ARTICLE ELEVENTH

            The Corporation reserves the right to amend, alter, change or repeal
any provision contained in this Amended and Restated Certificate of
Incorporation in the manner now or hereafter prescribed herein and by the laws
of the State of Delaware, and all rights conferred upon stockholders herein are
granted subject to this reservation.

            IN WITNESS WHEREOF, the undersigned Corporation has caused this
Amended and Restated Certificate of Incorporation to be signed by its duly
authorized officer, who affirms, under penalties of perjury, that the facts
stated herein are true and that this Amended and Restated Certificate of
Incorporation was adopted by a majority of the shareholders in accordance with
Section 242(b) and Section 245.

                                       IMMTECH INTERNATIONAL, INC.

                                       By: /s/ T. Stephen Thompson
                                           ------------------------------
                                           T. Stephen Thompson
                                           President and Chief Executive
                                           Officer

            This Amended and Restated Certificate of Incorporation is attested
by the Secretary of the Corporation on this 14th day of June, 2004.

                                       Attest:

                                       /s/ Gary C. Parks
                                       -----------------
                                       Secretary

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