Document:

Common Unit Purchase Agreement dated June 17, 2008

 Exhibit 10.1 
 ATLAS PIPELINE HOLDINGS, L.P. 
 COMMON UNITS REPRESENTING LIMITED PARTNER INTERESTS 

Common Unit Purchase Agreement 
 June 17, 2008 
 Atlas America, Inc. 
 1845 Walnut Street, 10th Floor 
 Philadelphia, PA 19103 
 Atlas
Pipeline Holdings, L.P., a Delaware limited partnership (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell to Atlas America, Inc., a Delaware corporation (the “Investor”),
approximately $10 million of common units (the “Investor Units”) representing the limited partner interests in the Company (the “Common Units”), at the price of $32.50. 
 This is to confirm the agreement between the Company and the Investor concerning the purchase of the Investor Units from the Company by the Investor.

 1. Representations, Warranties and Agreements. 
  

	 	(a)	The Company represents and warrants to, and agrees with, each Investor that: 

  

	 	(i)	The Company has been duly formed and is validly existing in good standing as a limited partnership under the Delaware Limited Partnership Act (the “Delaware Act”) with
full power and authority to enter into and perform its obligations under this Agreement. 

  

	 	(ii)	The Company has all requisite power and authority to issue, sell and deliver the Investor Units in accordance with and upon the terms and conditions set forth in this Agreement and
the LP Agreement. 

  

	 	(iii)	As of the Closing Date (as defined in Section 3), the Investor Units will be duly authorized by the Company’s Limited Partnership Agreement, as amended (the “LP
Agreement”) and, when issued and delivered to the Investor against payment therefor in accordance with the terms hereof, will be validly issued, fully paid and non-assessable. 

  

	 	(iv)	This Agreement has been duly executed and delivered by the Company. 

  

	 	(b)	The Investor represents and warrants to, and agrees with, the Company that: 

  

	 	(i)	 Investor is an “accredited investor,” as such term is defined in Rule 501(a) of Regulation D promulgated under the Securities Act of 1933, as amended (the
“Securities Act”), and the investment by the Investor in the Company is for its own account and not for the account of others, for investment purposes. The Investor Units are being acquired for its own account, for investment and with no
intention of distributing or reselling such Investor Units or any portion thereof or interest therein in any transaction which would be a violation of the 

	 	 
securities laws of the United States of America or any state or foreign country or jurisdiction. 

  

	 	(ii)	Investor acknowledges and agrees that it has been provided, to its full satisfaction, with the opportunity to ask questions concerning the terms and conditions of an investment in
the Company and has knowingly and voluntarily elected instead to rely solely on its own investigation. 

  

	 	(iii)	Investor acknowledges and agrees that the Investor must bear the economic risk of this investment indefinitely, that the Investor Units purchased by the Investor hereunder may not
be sold or transferred or offered for sale or transfer by it without registration under the Securities Act and any applicable state securities or Blue Sky laws or the availability of exemptions therefrom, and that the Company has no present
intention of registering the resale of any of such Investor Units. 

  

	 	(iv)	Investor has such knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in
the Investor Units, and has so evaluated the merits and risks of such investment. The Investor is able to bear the economic risk of an investment in the Investor Units and, at the present time and in the foreseeable future, is able to afford a
complete loss of such investment. 

  

	 	(v)	Investor understands that the Investor Units are being offered and sold to the Investor in reliance upon specific exemptions from the registration requirements of United States
federal and state securities laws and that the Company is relying upon the truth and accuracy of, and Investor’s compliance with, the representations, warranties, agreements, acknowledgments and understandings, which are true, correct and
complete, of the Investor set forth herein in order to determine the availability of such exemptions and the eligibility of the Investor to acquire the Investor Units. 

  

	 	(vi)	Investor has all requisite power and authority to purchase the Investor Units, in accordance with and upon the terms and conditions set forth in this Agreement.

  

	 	(vii)	This Agreement has been duly executed and delivered by the Investor. 

 2. Purchase and Sale. Subject to the terms and conditions herein set forth, the Company agrees to sell to the Investor, and the Investor hereby agrees to purchase from the Company, the Investor Units.

 3. Delivery and Payment for the Investor Units. Delivery of and payment for the Investor Units shall be made at 10 a.m., New York
City time, on the closing date of Atlas Pipeline Partners, L.P.’s (“APL”) public offering of its common units (such date and time of delivery and payment for the Investor Units being herein called the “Closing Date”).
Delivery of the Investor Units shall be made to the Investor against payment by the Investor of the purchase price thereof to or upon the order of the Company by wire transfer payable in same-day funds to an account specified by the Company.

 4. Condition of Investor’s Obligations. The obligations of the Investor hereunder, as to the Investor Units, shall be subject,
in its discretion, to the condition that all representations and warranties and other statements of the Company herein are, at and as of the Closing Date, true and correct, the condition that the Company shall have performed all of its obligations
hereunder 

 
theretofore to be performed, and the closing of the purchase and sale of APL’s common units pursuant to the underwriting agreement, dated the date
hereof, among the APL, the underwriters named therein and certain other parties shall have occurred. 
 5. Binding Nature of
Agreement. This Agreement shall be binding upon, and inure solely to the benefit of, the Investor and the Company, and their respective heirs, executors, administrators, successors and assigns, and no other person shall acquire or have any right
under or by virtue of this Agreement. 
 6. Sole Agreement. This Agreement supersedes all prior agreements and understandings (whether
written or oral) between the Company and the Investor, with respect to the subject matter hereof. 
 7. Governing Law. This Agreement
shall be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania. 
 8. Execution in Counterpart.
This Agreement may be executed by any one or more of the parties hereto in any number of counterparts, each of which shall be deemed to be an original, but all such counterparts shall together constitute one and the same instrument. 
 [SIGNATURES APPEAR ON FOLLOWING PAGE] 

 Upon the acceptance hereof by the Investor, this letter and such acceptance hereof shall constitute a
binding agreement between the Investor and the Company. 
  

			
	Very truly yours,
	
	ATLAS PIPELINE HOLDINGS, L.P.
		
	By:	 	Atlas Pipeline Holdings GP, LLC
		
	By:	 	  

	Name:	 	
	Title	 	

 Accepted as of the date hereof: 
  

			
	ATLAS AMERICA, INC.
		
	By:	 	  

	Name:	 	
	Title:2008 Employee Stock Purchase Plan and Form of Offering Document

 Exhibit 10.1 
 TORREYPINES THERAPEUTICS, INC. 
 2008
EMPLOYEE STOCK PURCHASE PLAN 
 ADOPTED BY
THE BOARD OF DIRECTORS: APRIL 24, 2008 
 APPROVED BY THE STOCKHOLDERS: JUNE 19, 2008 
  

	1.	GENERAL. 

 (a) The purpose of
the Plan is to provide a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase shares of Common Stock. The Plan is intended to permit the Company to grant a series of
Purchase Rights to Eligible Employees under an Employee Stock Purchase Plan. 
 (b) The Company, by means of the Plan, seeks to retain
the services of such Employees, to secure and retain the services of new Employees and to provide incentives for such persons to exert maximum efforts for the success of the Company and its Related Corporations. 
  

	2.	ADMINISTRATION. 

 (a) The
Board shall administer the Plan unless and until the Board delegates administration of the Plan to a Committee or Committees, as provided in Section 2(c). 
 (b) The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan: 
 (i) To determine how and when Purchase Rights to purchase shares of Common Stock shall be granted and the provisions of each Offering of such Purchase Rights (which need not be identical). 
 (ii) To designate from time to time which Related Corporations of the Company shall be eligible to participate in the Plan.

 (iii) To construe and interpret the Plan and Purchase Rights, and to establish, amend and revoke rules and
regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully effective.

 (iv) To settle all controversies regarding the Plan and Purchase Rights granted under it. 
 (v) To suspend or terminate the Plan at any time as provided in Section 12. 
 (vi) To amend the Plan at any time as provided in Section 12. 

 (vii) Generally, to exercise such powers and to perform such acts as it deems
necessary or expedient to promote the best interests of the Company and its Related Corporations and to carry out the intent that the Plan be treated as an Employee Stock Purchase Plan. 
 (viii) To adopt such procedures and sub-plans as are necessary or appropriate to permit participation in the Plan by Employees who
are foreign nationals or employed outside the United States. 
 (c) The Board may delegate some or all of the administration of the
Plan to a Committee or Committees. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board that have been delegated to the Committee,
including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board shall thereafter be to the Committee or subcommittee), subject, however, to such
resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Board may retain the authority to concurrently administer the Plan with the Committee and may, at any time, revest in the Board some
or all of the powers previously delegated. Whether or not the Board has delegated administration of the Plan to a Committee, the Board shall have the final power to determine all questions of policy and expediency that may arise in the
administration of the Plan. 
 (d) All determinations, interpretations and constructions made by the Board in good faith shall not be
subject to review by any person and shall be final, binding and conclusive on all persons. 
  

	3.	SHARES OF COMMON STOCK SUBJECT TO THE PLAN.

 (a) Subject to the provisions of Section 11(a) relating to Capitalization Adjustments, the shares of Common
Stock that may be sold pursuant to Purchase Rights shall not exceed in the aggregate one million (1,000,000) shares of Common Stock. 
 (b) If any Purchase Right granted under the Plan shall for any reason terminate without having been exercised, the shares of Common Stock not purchased under such Purchase Right shall again become available for issuance under the
Plan. 
 (c) The stock purchasable under the Plan shall be shares of authorized but unissued or reacquired Common Stock, including
shares repurchased by the Company on the open market. 
  

	4.	GRANT OF PURCHASE RIGHTS; OFFERING. 

 (a) The Board may from time to time grant or provide for the grant of Purchase Rights to purchase shares of Common Stock under the Plan to Eligible
Employees in an Offering (consisting of one or more Purchase Periods) on an Offering Date or Offering Dates selected by the Board. Each Offering shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate,
which shall comply with the requirement of Section 423(b)(5) of the Code that all Employees granted Purchase Rights shall have the same rights and privileges. The terms and conditions of an Offering shall be incorporated by reference into the
Plan and treated as part of the Plan. The provisions of separate Offerings need not be identical, but each Offering shall include (through 

 
incorporation of the provisions of this Plan by reference in the document comprising the Offering or otherwise) the period during which the Offering shall be
effective, which period shall not exceed twenty-seven (27) months beginning with the Offering Date, and the substance of the provisions contained in Sections 5 through 8, inclusive. 
 (b) If a Participant has more than one Purchase Right outstanding under the Plan, unless he or she otherwise indicates in agreements or notices
delivered hereunder: (i) each agreement or notice delivered by that Participant shall be deemed to apply to all of his or her Purchase Rights under the Plan, and (ii) a Purchase Right with a lower exercise price (or an earlier-granted
Purchase Right, if different Purchase Rights have identical exercise prices) shall be exercised to the fullest possible extent before a Purchase Right with a higher exercise price (or a later-granted Purchase Right if different Purchase Rights have
identical exercise prices) shall be exercised. 
 (c) The Board shall have the discretion to structure an Offering so that if the Fair
Market Value of the shares of Common Stock on the first day of a new Purchase Period within that Offering is less than or equal to the Fair Market Value of the shares of Common Stock on the Offering Date, then (i) that Offering shall terminate
immediately, and (ii) the Participants in such terminated Offering shall be automatically enrolled in a new Offering beginning on the first day of such new Purchase Period. 
  

	5.	ELIGIBILITY. 

 (a) Purchase
Rights may be granted only to Employees of the Company or, as the Board may designate as provided in Section 2(b), to Employees of a Related Corporation. Except as provided in Section 5(b), an Employee shall not be eligible to be granted
Purchase Rights under the Plan unless, on the Offering Date, such Employee has been in the employ of the Company or the Related Corporation, as the case may be, for such continuous period preceding such Offering Date as the Board may require, but in
no event shall the required period of continuous employment be greater than two (2) years. In addition, the Board may provide that no Employee shall be eligible to be granted Purchase Rights under the Plan unless, on the Offering Date, such
Employee’s customary employment with the Company or the Related Corporation is thirty-two (32) hours per week or more or such other criteria as the Board may determine consistent with Section 423 of the Code. 
 (b) The Board may provide that each person who, during the course of an Offering, first becomes an Eligible Employee shall, on a date or dates
specified in the Offering which coincides with the day on which such person becomes an Eligible Employee or which occurs thereafter, receive a Purchase Right under that Offering, which Purchase Right shall thereafter be deemed to be a part of that
Offering. Such Purchase Right shall have the same characteristics as any Purchase Rights originally granted under that Offering, as described herein, except that: 
 (i) the date on which such Purchase Right is granted shall be the “Offering Date” of such Purchase Right for all
purposes, including determination of the exercise price of such Purchase Right; 

 (ii) the period of the Offering with respect to such Purchase Right shall begin on
its Offering Date and end coincident with the end of such Offering; and 
 (iii) the Board may provide that if such
person first becomes an Eligible Employee within a specified period of time before the end of the Offering, he or she shall not receive any Purchase Right under that Offering. 
 (c) No Employee shall be eligible for the grant of any Purchase Rights under the Plan if, immediately after any such Purchase Rights are granted,
such Employee owns stock possessing five percent (5%) or more of the total combined voting power or value of all classes of stock of the Company or of any Related Corporation. For purposes of this Section 5(c), the rules of
Section 424(d) of the Code shall apply in determining the stock ownership of any Employee, and stock which such Employee may purchase under all outstanding Purchase Rights and options shall be treated as stock owned by such Employee.

 (d) As specified by Section 423(b)(8) of the Code, an Eligible Employee may be granted Purchase Rights under the Plan only if
such Purchase Rights, together with any other rights granted under all Employee Stock Purchase Plans of the Company and any Related Corporations, do not permit such Eligible Employee’s rights to purchase stock of the Company or any Related
Corporation to accrue at a rate which exceeds twenty five thousand dollars ($25,000) of Fair Market Value of such stock (determined at the time such rights are granted, and which, with respect to the Plan, shall be determined as of their respective
Offering Dates) for each calendar year in which such rights are outstanding at any time. 
 (e) Officers of the Company and any
designated Related Corporation, if they are otherwise Eligible Employees, shall be eligible to participate in Offerings under the Plan. Notwithstanding the foregoing, the Board may provide in an Offering that Employees who are highly compensated
Employees within the meaning of Section 423(b)(4)(D) of the Code shall not be eligible to participate. 
  

	6.	PURCHASE RIGHTS; PURCHASE PRICE. 

 (a) On each Offering Date, each Eligible Employee, pursuant to an Offering made under the Plan, shall be granted a Purchase Right to purchase up to
that number of shares of Common Stock purchasable either with a percentage or with a maximum dollar amount, as designated by the Board, but in either case not exceeding fifteen percent (15%) of such Employee’s earnings (as defined by the
Board in each Offering) during the period that begins on the Offering Date (or such later date as the Board determines for a particular Offering) and ends on the date stated in the Offering, which date shall be no later than the end of the Offering.

 (b) The Board shall establish one (1) or more Purchase Dates during an Offering as of which Purchase Rights granted pursuant
to that Offering shall be exercised and purchases of shares of Common Stock shall be carried out in accordance with such Offering. 
 (c) In connection with each Offering made under the Plan, the Board may specify a maximum number of shares of Common Stock that may be purchased by any Participant on any Purchase Date during such Offering. In connection with each
Offering made under the Plan, the Board may specify a maximum aggregate number of shares of Common Stock that may be purchased by all 

 
Participants pursuant to such Offering. In addition, in connection with each Offering that contains more than one Purchase Date, the Board may specify a
maximum aggregate number of shares of Common Stock that may be purchased by all Participants on any Purchase Date under the Offering. If the aggregate purchase of shares of Common Stock issuable upon exercise of Purchase Rights granted under the
Offering would exceed any such maximum aggregate number, then, in the absence of any Board action otherwise, a pro rata allocation of the shares of Common Stock available shall be made in as nearly a uniform manner as shall be practicable and
equitable. 
 (d) The purchase price of shares of Common Stock acquired pursuant to Purchase Rights shall be not less than the lesser
of: 
 (i) an amount equal to eighty-five percent (85%) of the Fair Market Value of the shares of Common Stock on
the Offering Date; or 
 (ii) an amount equal to eighty-five percent (85%) of the Fair Market Value of the shares
of Common Stock on the applicable Purchase Date. 
  

	7.	PARTICIPATION; WITHDRAWAL; TERMINATION. 

 (a) A Participant may elect to authorize payroll deductions pursuant to an Offering under the Plan by completing and delivering to the Company,
within the time specified in the Offering, an enrollment form (in such form as the Company may provide). Each such enrollment form shall authorize an amount of Contributions expressed as a percentage of the submitting Participant’s earnings (as
defined in each Offering) during the Offering (not to exceed the maximum percentage specified by the Board). Each Participant’s Contributions shall be credited to a bookkeeping account for such Participant under the Plan and shall be deposited
with the general funds of the Company except where applicable law requires that Contributions be deposited with a third party. To the extent provided in the Offering, a Participant may begin such Contributions after the beginning of the Offering. To
the extent provided in the Offering, a Participant may thereafter reduce (including to zero) or increase his or her Contributions. 
 (b) During an Offering, a Participant may cease making Contributions and withdraw from the Offering by delivering to the Company a notice of withdrawal in such form as the Company may provide. Such withdrawal may be elected at any
time prior to the end of the Offering, except as provided otherwise in the Offering. Upon such withdrawal from the Offering by a Participant, the Company shall distribute to such Participant all of his or her accumulated Contributions (reduced to
the extent, if any, such Contributions have been used to acquire shares of Common Stock for the Participant) under the Offering, and such Participant’s Purchase Right in that Offering shall thereupon terminate. A Participant’s withdrawal
from an Offering shall have no effect upon such Participant’s eligibility to participate in any other Offerings under the Plan, but such Participant shall be required to deliver a new enrollment form in order to participate in subsequent
Offerings. 
 (c) Purchase Rights granted pursuant to any Offering under the Plan shall terminate immediately upon a Participant
ceasing to be an Employee for any reason or for no reason (subject to any post-employment participation period required by law) or other lack of eligibility. 

 
The Company shall distribute to such terminated or otherwise ineligible Employee all of his or her accumulated Contributions (reduced to the extent, if any,
such Contributions have been used to acquire shares of Common Stock for the terminated or otherwise ineligible Employee) under the Offering. 
 (d) Purchase Rights shall not be transferable by a Participant except by will, the laws of descent and distribution, or by a beneficiary designation as provided in Section 10. During a Participant’s lifetime, Purchase
Rights shall be exercisable only by such Participant. 
 (e) Unless otherwise specified in an Offering, the Company shall have no
obligation to pay interest on Contributions. 
  

	8.	EXERCISE OF PURCHASE RIGHTS. 

 (a) On each Purchase Date during an Offering, each Participant’s accumulated Contributions shall be applied to the purchase of shares of
Common Stock up to the maximum number of shares of Common Stock permitted pursuant to the terms of the Plan and the applicable Offering, at the purchase price specified in the Offering. No fractional shares shall be issued upon the exercise of
Purchase Rights unless specifically provided for in the Offering. 
 (b) If any amount of accumulated Contributions remains in a
Participant’s account after the purchase of shares of Common Stock and such remaining amount is less than the amount required to purchase one share of Common Stock on the final Purchase Date of an Offering, then such remaining amount shall be
held in such Participant’s account for the purchase of shares of Common Stock under the next Offering under the Plan, unless such Participant withdraws from such next Offering, as provided in Section 7(b), or is not eligible to participate
in such Offering, as provided in Section 5, in which case such amount shall be distributed to such Participant after the final Purchase Date, without interest. If the amount of Contributions remaining in a Participant’s account after the
purchase of shares of Common Stock is at least equal to the amount required to purchase one (1) whole share of Common Stock on the final Purchase Date of the Offering, then such remaining amount shall be distributed in full to such Participant
at the end of the Offering without interest. 
 (c) No Purchase Rights may be exercised to any extent unless the shares of Common
Stock to be issued upon such exercise under the Plan are covered by an effective registration statement pursuant to the Securities Act and the Plan is in material compliance with all applicable federal, state, foreign and other securities and other
laws applicable to the Plan. If on a Purchase Date during any Offering hereunder the shares of Common Stock are not so registered or the Plan is not in such compliance, no Purchase Rights or any Offering shall be exercised on such Purchase Date, and
the Purchase Date shall be delayed until the shares of Common Stock are subject to such an effective registration statement and the Plan is in such compliance, except that the Purchase Date shall not be delayed more than twelve (12) months and
the Purchase Date shall in no event be more than twenty-seven (27) months from the Offering Date. If, on the Purchase Date under any Offering hereunder, as delayed to the maximum extent permissible, the shares of Common Stock are not registered
and the Plan is not in such compliance, no Purchase Rights or any Offering shall be exercised and all Contributions accumulated during the Offering (reduced to the extent, if any, such Contributions have been used to acquire shares of Common Stock)
shall be distributed to the Participants without interest. 

	9.	COVENANTS OF THE COMPANY. 

 The Company shall seek to obtain from each federal, state, foreign or other regulatory commission or agency having jurisdiction over the Plan such
authority as may be required to issue and sell shares of Common Stock upon exercise of the Purchase Rights. If, after commercially reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority that
counsel for the Company deems necessary for the lawful issuance and sale of Common Stock under the Plan, the Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Purchase Rights unless and
until such authority is obtained. 
  

	10.	DESIGNATION OF BENEFICIARY. 

 (a) A Participant may file a written designation of a beneficiary who is to receive any shares of Common Stock and/or cash, if any, from the Participant’s account under the Plan in the event of such
Participant’s death subsequent to the end of an Offering but prior to delivery to the Participant of such shares of Common Stock or cash. In addition, a Participant may file a written designation of a beneficiary who is to receive any cash from
the Participant’s account under the Plan in the event of such Participant’s death during an Offering. Any such designation shall be on a form provided by or otherwise acceptable to the Company. 
 (b) The Participant may change such designation of beneficiary at any time by written notice to the Company. In the event of the death of a
Participant and in the absence of a beneficiary validly designated under the Plan who is living at the time of such Participant’s death, the Company shall deliver such shares of Common Stock and/or cash to the executor or administrator of the
estate of the Participant, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its sole discretion, may deliver such shares of Common Stock and/or cash to the spouse or to any one or more
dependents or relatives of the Participant, or if no spouse, dependent or relative is known to the Company, then to such other person as the Company may designate. 
  

	11.	ADJUSTMENTS UPON CHANGES IN COMMON STOCK; CORPORATE
TRANSACTIONS. 

 (a) In the event of a Capitalization Adjustment, the Board shall appropriately and
proportionately adjust: (i) the class(es) and maximum number of securities subject to the Plan pursuant to Section 3(a), (ii) the class(es) and maximum number of securities by which the share reserve is to increase automatically each
year pursuant to Section 3(a), (iii) the class(es) and number of securities subject to, and the purchase price applicable to outstanding Offerings and Purchase Rights, and (iv) the class(es) and number of securities imposed by
purchase limits under each ongoing Offering. The Board shall make such adjustments as necessary to prevent the enlargement or dilution of such amounts, and its determination shall be final, binding and conclusive. 

 (b) In the event of a Corporate Transaction, then: (i) any surviving corporation or acquiring
corporation (or the surviving or acquiring corporation’s parent company) may assume or continue Purchase Rights outstanding under the Plan or may substitute similar rights (including a right to acquire the same consideration paid to the
stockholders in the Corporate Transaction) for those outstanding under the Plan, or (ii) if any surviving or acquiring corporation (or its parent company) does not assume or continue such Purchase Rights or does not substitute similar rights
for Purchase Rights outstanding under the Plan, then the Participants’ accumulated Contributions shall be used to purchase shares of Common Stock within ten (10) business days prior to the Corporate Transaction under any ongoing Offerings,
and the Participants’ Purchase Rights under the ongoing Offerings shall terminate immediately after such purchase. 
  

	12.	AMENDMENT, TERMINATION OR SUSPENSION OF THE PLAN.

 (i) The Board may amend the Plan at any time in any respect the Board deems necessary or
advisable. However, except as provided in Section 11(a) relating to Capitalization Adjustments, stockholder approval shall be required for any amendment of the Plan for which stockholder approval is required by applicable law or listing
requirements, including any amendment that either (i) materially increases the number of shares of Common Stock available for issuance under the Plan, (ii) materially expands the class of individuals eligible to become Participants and
receive Purchase Rights under the Plan, (iii) materially increases the benefits accruing to Participants under the Plan or materially reduces the price at which shares of Common Stock may be purchased under the Plan, (iv) materially
extends the term of the Plan, or (v) expands the types of awards available for issuance under the Plan, but in each of (i) through (v) above only to the extent stockholder approval is required by applicable law or listing
requirements. 
 (b) The Board may suspend or terminate the Plan at any time. No Purchase Rights may be granted under the Plan while
the Plan is suspended or after it is terminated. 
 (c) Any benefits, privileges, entitlements and obligations under any outstanding
Purchase Rights granted before an amendment, suspension or termination of the Plan shall not be impaired by any such amendment, suspension or termination except (i) with the consent of the person to whom such Purchase Rights were granted,
(ii) as necessary to comply with any laws, listing requirements, or governmental regulations (including, without limitation, the provisions of Section 423 of the Code and the regulations and other interpretive guidance issued thereunder
relating to Employee Stock Purchase Plans) including without limitation any such regulations or other guidance that may be issued or amended after the effective date, or (iii) as necessary to obtain or maintain favorable tax, listing, or
regulatory treatment. 
  

	13.	EFFECTIVE DATE OF PLAN. 

 The Plan shall become effective on April 23, 2008, but no Purchase Rights shall be exercised unless and until the Plan has been approved by the
stockholders of the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 

	14.	MISCELLANEOUS PROVISIONS. 

 (a) Proceeds from the sale of shares of Common Stock pursuant to Purchase Rights shall constitute general funds of the Company. 
 (b) A Participant shall not be deemed to be the holder of, or to have any of the rights of a holder with respect to, shares of Common Stock subject to Purchase Rights unless and until the Participant’s shares of Common Stock
acquired upon exercise of Purchase Rights are recorded in the books of the Company (or its transfer agent). 
 (c) The Plan and
Offering do not constitute an employment contract. Nothing in the Plan or in the Offering shall in any way alter the at will nature of a Participant’s employment or be deemed to create in any way whatsoever any obligation on the part of any
Participant to continue in the employ of the Company or a Related Corporation, or on the part of the Company or a Related Corporation to continue the employment of a Participant. 
 (d) The provisions of the Plan shall be governed by the laws of the State of California without resort to that state’s conflicts of laws
rules. 
  

	15.	DEFINITIONS. 

 As used in the Plan,
the following definitions shall apply to the capitalized terms indicated below: 
 (a) “Board” means the Board
of Directors of the Company. 
 (b) “Capitalization Adjustment” means any change that is made in, or other
events that occur with respect to, the Common Stock subject to the Plan or subject to any Purchase Right after the effective date without the receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization,
reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other similar transaction). Notwithstanding the foregoing, the
conversion of any convertible securities of the Company shall not be treated as a Capitalization Adjustment. 
 (c)
“Code” means the Internal Revenue Code of 1986, as amended. 
 (d) “Committee” means a
committee of one (1) or more members of the Board to whom authority has been delegated by the Board in accordance with Section 2(c). 
 (e) “Common Stock” means the common stock of the Company. 
 (f)
“Company” means TorreyPines Therapeutics, Inc., a Delaware corporation. 
 (g)
“Contributions” means the payroll deductions and other additional payments specifically provided for in the Offering, that a Participant contributes to fund the exercise of a Purchase Right. A Participant may make additional
payments into his or her account, if specifically provided for in the Offering, and then only if the Participant has not already had the maximum permitted amount withheld during the Offering through payroll deductions. 

 (h) “Corporate Transaction” means the occurrence, in a single transaction
or in a series of related transactions, of any one or more of the following events: 
 (i) the consummation of a sale
or other disposition of all or substantially all, as determined by the Board in its sole discretion, of the consolidated assets of the Company and its Subsidiaries; 
 (ii) the consummation of a sale or other disposition of at least ninety percent (90%) of the outstanding securities of the
Company; 
 (iii) the consummation of a merger, consolidation or similar transaction following which the Company is not
the surviving corporation; or 
 (iv) the consummation of a merger, consolidation or similar transaction following
which the Company is the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of the merger, consolidation or similar transaction
into other property, whether in the form of securities, cash or otherwise. 
 (i) “Director” means a member of
the Board. 
 (j) “Eligible Employee” means an Employee who meets the requirements set forth in the Offering
for eligibility to participate in the Offering, provided that such Employee also meets the requirements for eligibility to participate set forth in the Plan. 
 (k) “Employee” means any person, including Officers and Directors, who is employed for purposes of Section 423(b)(4) of the Code by the Company or a Related Corporation. However,
service solely as a Director, or payment of a fee for such services, shall not cause a Director to be considered an “Employee” for purposes of the Plan. 
 (l) “Employee Stock Purchase Plan” means a plan that grants Purchase Rights intended to be options issued under an “employee stock purchase plan,” as that term is defined in
Section 423(b) of the Code. 
 (m) “Exchange Act” means the Securities Exchange Act of 1934, as amended.

 (n) “Fair Market Value” means, as of any date, the value of the Common Stock determined as follows:

 (i) If the Common Stock is listed on any established stock exchange or traded on any established market, the Fair
Market Value of a share of Common Stock shall be the closing sales price for such stock as quoted on such exchange or market (or the exchange or market with the greatest volume of trading in the Common Stock) on the date of determination, as
reported in The Wall Street Journal or such other source as the Board deems reliable. Unless otherwise provided by the Board, if there is no closing sales price for the Common Stock on the date of determination, then the Fair Market Value
shall be the closing selling price on the last preceding date for which such quotation exists. 

 (ii) In the absence of such markets for the Common Stock, the Fair Market Value
shall be determined by the Board in good faith. 
 (o) “Offering” means the grant of Purchase Rights to
purchase shares of Common Stock under the Plan to Eligible Employees. 
 (p) “Offering Date” means a date
selected by the Board for an Offering to commence. 
 (q) “Officer” means a person who is an officer of the
Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 
 (r)
“Participant” means an Eligible Employee who holds an outstanding Purchase Right granted pursuant to the Plan. 
 (s) “Plan” means this TorreyPines Therapeutics, Inc. 2008 Employee Stock Purchase Plan. 
 (t)
“Purchase Date” means one or more dates during an Offering established by the Board on which Purchase Rights shall be exercised and as of which purchases of shares of Common Stock shall be carried out in accordance with such
Offering. 
 (u) “Purchase Period” means a period of time specified within an Offering beginning on the
Offering Date or on the next day following a Purchase Date within an Offering and ending on a Purchase Date. An Offering may consist of one or more Purchase Periods. 
 (v) “Purchase Right” means an option to purchase shares of Common Stock granted pursuant to the Plan. 
 (w) “Related Corporation” means any “parent corporation” or “subsidiary corporation” of the Company whether now or subsequently established, as those terms are
defined in Sections 424(e) and (f), respectively, of the Code. 
 (x) “Securities Act” means the Securities
Act of 1933, as amended. 
 (y) “Trading Day” means any day on which the exchange(s) or market(s) on which
shares of Common Stock are listed is open for trading. 

 TORREYPINES THERAPEUTICS, INC.

 2008 EMPLOYEE STOCK PURCHASE PLAN 
 FORM OF OFFERING DOCUMENT 
 ADOPTED BY THE BOARD OF DIRECTORS: APRIL 24, 2008 
 In this document, capitalized terms not otherwise defined shall have the same definitions of such terms as in the TorreyPines Therapeutics, Inc. 2008
Employee Stock Purchase Plan (the “Plan”). 
  

	1.	GRANT; OFFERING DATE. 

 (a) Pursuant to the Plan, the Board hereby authorizes a series of Offerings pursuant to the terms of this Offering document. Each Offering shall consist of the grant of rights to purchase shares of Common Stock
to all Eligible Employees. Each Offering shall be approximately two (2) years in duration, with four (4) Purchase Periods each of which shall be approximately six (6) months in length, however the first Offering shall consist of one
Purchase Period of five months in length and three Purchase Periods of six months in length. The first Offering shall begin on July 1, 2008, and shall include a series of four (4) Purchase Periods beginning on July 1,
2008, December 1, 2008, June 1, 2009 and December 1, 2009, each with Purchase Dates occurring on the last date of the Purchase Period or the Offering, as the case may be. Thereafter an Offering shall begin on June 1,
2010 and such Offering shall end on the day prior to the second anniversary of its Offering Date. The first day of an Offering is that Offering’s “Offering Date.” In no event may an Offering commence after the Plan is terminated.

 (b) Notwithstanding the foregoing: (i) if any Offering Date falls on a day that is not a Trading Day, then such Offering Date
shall instead fall on the next subsequent Trading Day, and (ii) if any Purchase Date falls on a day that is not a Trading Day, then such Purchase Date shall instead fall on the immediately preceding Trading Day. 
 (c) Prior to the commencement of any Offering, the Board (or the Committee described in Section 2(c) of the Plan, if any) may change any or
all terms of such Offering and any subsequent Offerings. The granting of Purchase Rights pursuant to each Offering hereunder shall occur on each respective Offering Date unless prior to such date (i) the Board determines that such Offering
shall not occur, or (ii) no shares of Common Stock remain available for issuance under the Plan in connection with the Offering. 
  

	2.	ELIGIBLE EMPLOYEES. 

 (a) Each Eligible Employee who is either (i) an employee of the Company; or (ii) an employee of a Related Corporation incorporated in the United States; or (iii) an employee of a Related Corporation that is not
incorporated in the United States, provided that the Board (or the Committee described in Section 2(c) of the Plan, if any) has designated the employees of such Related Corporation as eligible to participate in the Offering, shall be granted a
Purchase Right on the Offering Date of such Offering, provided however, that each such Eligible Employee otherwise meets the employment requirements of Section 5(a) of the Plan and that each Eligible Employee may only contribute to one
Offering at any given point in time. 

 (b) Each person who, during the course of an Offering, first becomes an Eligible Employee prior to
the commencement of the last Purchase Period under the Offering shall, on the first Trading Day of the first Purchase Period that commences after such person becomes an Eligible Employee, receive a Purchase Right under that Offering, which Purchase
Right shall thereafter be deemed to be a part of that Offering; provided, however, that such Eligible Employee submits the necessary enrollment paperwork required by the Company on or before such date. Such Purchase Right shall have the same
characteristics as any Purchase Rights originally granted under that Offering, as described herein, except that: 
 (i)
the date on which such Purchase Right is granted shall be the “Offering Date” of such Purchase Right for all purposes, including determination of the exercise price of such Purchase Right; and 
 (ii) the period of the Offering with respect to such Purchase Right shall begin on its Offering Date and end coincident with the
end of such Offering. 
 (c) Notwithstanding the foregoing, the following Employees shall not be Eligible Employees or be
granted Purchase Rights under an Offering: 
 (i) Employees whose customary employment is less than thirty-two
(32) hours per week; 
 (ii) five percent (5%) stockholders (including ownership through unexercised and/or
unvested stock options) as described in Section 5(c) of the Plan; or 
 (iii) Employees in jurisdictions outside
of the United States if, as of the Offering Date of the Offering, the grant of such Purchase Rights would not be in compliance with the applicable laws of any jurisdiction in which the Employee resides or is employed; provided, however, that
no Participant may have more than fifteen percent (15%) of such Participant’s Earnings applied to purchase shares of Common Stock under all other plans of the Company and Related Corporations that are intended to qualify as Employee Stock
Purchase Plans. 
  

	3.	PURCHASE RIGHTS. 

 (a) Subject to the limitations herein and in the Plan, a Participant’s Purchase Right shall permit the purchase of the number of shares of Common Stock purchasable with up to fifteen percent (15%) of such Participant’s
Earnings paid during the period of such Offering beginning immediately after such Participant first commences participation. 
 (b)
For Offerings hereunder, “Earnings” means the base compensation paid to a Participant, including all salary, wages (including amounts elected to be deferred by such Participant, that would otherwise have been paid, under any
cash or deferred arrangement or other deferred compensation program established by the Company or a Related Corporation), but excluding all of the following: all overtime pay, commissions, bonuses, and other remuneration paid directly to such
Participant, profit sharing, the cost 

 
of employee benefits paid for by the Company or a Related Corporation, education or tuition reimbursements, imputed income arising under any Company or
Related Corporation group insurance or benefit program, traveling expenses, business and moving expense reimbursements, income received in connection with stock options and other equity awards, contributions made by the Company or a Related
Corporation under any employee benefit plan, and other similar items of compensation. 
 (c) Notwithstanding the foregoing, the
maximum number of shares of Common Stock that a Participant may purchase on any Purchase Date in an Offering shall be such number of shares as has a Fair Market Value (determined as of the Offering Date for such Offering) equal to (x) $25,000
multiplied by the number of calendar years in which the Purchase Right under such Offering has been outstanding at any time, minus (y) the Fair Market Value of any other shares of Common Stock (determined as of the relevant Offering Date with
respect to such shares) that, for purposes of the limitation of Section 423(b)(8) of the Code, are attributed to any of such calendar years in which the Purchase Right is outstanding. The amount in clause (y) of the previous sentence shall
be determined in accordance with regulations applicable under Section 423(b)(8) of the Code based on (i) the number of shares previously purchased with respect to such calendar years pursuant to such Offering or any other Offering under
the Plan, or pursuant to any other Company or Related Corporation plans intended to qualify as Employee Stock Purchase Plans, and (ii) the number of shares subject to other Purchase Rights outstanding on the Offering Date for such Offering
pursuant to the Plan or any other such Company or Related Corporation Employee Stock Purchase Plan. 
 (d) The maximum aggregate
number of shares of Common Stock available to be purchased by all Participants under an Offering shall be the number of shares of Common Stock remaining available under the Plan on the Offering Date, rounded down to the nearest whole share. If the
aggregate purchase of shares of Common Stock upon exercise of Purchase Rights granted under the Offering would exceed the maximum aggregate number of shares available, the Board (or the Committee described in Section 2(c) of the Plan, if any)
shall make a pro rata allocation of the shares available in a uniform and equitable manner. Any Contributions not applied to the purchase of available shares of Common Stock shall be refunded to the Participants without interest. 
 (e) If the aggregate number of shares of Common Stock to be purchased upon the exercise of all outstanding Purchase Rights on a single Purchase
Date would exceed any of the foregoing limits, the Board (or the Committee described in Section 2(c) of the Plan, if any) shall make a uniform and equitable allocation of the shares available. Any Contributions not applied to the purchase of
available shares of Common Stock shall be refunded to the Participants without interest. 
  

	4.	PURCHASE PRICE. 

 The
purchase price of shares of Common Stock under an Offering shall be the lesser of: (i) eighty-five percent (85%) of the Fair Market Value of such shares of Common Stock on the Offering Date, or (ii) eighty-five percent (85%) of
the Fair Market Value of such shares of Common Stock on the applicable Purchase Date, in each case rounded up to the nearest whole cent per share. 

	5.	PARTICIPATION. 

 (a) An
Eligible Employee may elect to participate in an Offering to be effective on the Offering Date. An Eligible Employee may enroll in only one Offering at a time. An Eligible Employee shall elect his or her payroll deduction percentage on such
enrollment form as the Company provides. The completed enrollment form must be delivered to the Company at least ten (10) days prior to the date participation is to be effective, unless a later time for filing the enrollment form is set by the
Company for all Eligible Employees with respect to a given Offering. Payroll deduction percentages must be expressed in whole percentages of Earnings, with a minimum percentage of one percent (1%) and a maximum percentage of fifteen percent
(15%). A Participant may participate only by way of payroll deductions. 
 (b) A Participant may increase or decrease his or her
participation level at any time with such change to be effective commencing as of the next Offering. Any such increase or decrease in participation level shall be made by delivering a notice to the Company or a designated Related Corporation in such
form as the Company provides prior to the ten (10) day period (or such shorter period of time as determined by the Company and communicated to Participants) immediately preceding the next Offering Date for which it is to be effective. A
Participant may also increase or decrease his or her participation level to be effective in a subsequent Purchase Period of an ongoing Offering in accordance with procedures established by the Company; provided, however, that a participant
may not increase his or her participation level for a subsequent Purchase Period of an ongoing Offering beyond the payroll deduction percentage elected at the beginning of the Offering. 
 (c) A Participant may withdraw from an Offering and receive a refund of his or her Contributions (reduced to the extent, if any, such
Contributions have been used to acquire shares of Common Stock for the Participant on any prior Purchase Date) without interest, at any time prior to the end of the Offering, excluding only each ten (10) day period immediately preceding a
Purchase Date (or such shorter period of time determined by the Company and communicated to Participants), by delivering a withdrawal notice to the Company or a designated Related Corporation in such form as the Company provides. A Participant who
has withdrawn from an Offering may again participate in such Offering; provided, however, that the Participant cannot again participate in the Purchase Period ongoing at the time of his or her withdrawal nor can the Participant participate in
the subsequent Purchase Period. 
 (d) Notwithstanding the foregoing or any other provision of this Offering document or of the Plan
to the contrary, neither the enrollment of any Eligible Employee in the Plan nor any forms relating to participation in the Plan shall be given effect until such time as a registration statement covering the shares reserved under the Plan that are
subject to the Offering has been filed by the Company and has become effective. If the provisions of this Section are applicable, the Company shall establish such procedures as will enable the purposes of the Plan to be satisfied while complying
with applicable securities laws. Such procedures may include, for example, allowing Participants to participate other than by means of payroll deduction and/or allowing Participants to increase their level of participation during a Purchase Period.

 (e) Notwithstanding the foregoing or any other provision of this Offering document or of the Plan
to the contrary, the Company may determine in its sole discretion at any time, including at any time following the commencement of an Offering, that it will no longer accept Participant requests to increase participation levels during such Offering.

 (f) Once an Eligible Employee affirmatively enrolls in an Offering and authorizes payroll deductions, the Eligible Employee
automatically shall be enrolled for all subsequent Offerings until he or she elects to withdraw from an Offering pursuant to paragraph (c) above or terminates his or her participation in the Plan. 
  

	6.	PURCHASES. 

 Subject to the
limitations contained herein, on each Purchase Date, each Participant’s Contributions (without any increase for interest) shall be applied to the purchase of whole shares of Common Stock, up to the maximum number of shares permitted under the
Plan and the Offering. 
  

	7.	NOTICES AND AGREEMENTS. 

 Any notices or agreements provided for in an Offering or the Plan shall be given in writing, in a form provided by the Company (including documents delivered in electronic form, if authorized by the Committee), and
unless specifically provided for in the Plan or this Offering, shall be deemed effectively given upon receipt or, in the case of notices and agreements delivered by the Company, five (5) days after deposit in the United States mail, postage
prepaid. 
  

	8.	EXERCISE CONTINGENT ON STOCKHOLDER APPROVAL. 

 The Purchase Rights granted under an Offering are subject to the approval of the Plan by the stockholders of the Company as required for the Plan to
obtain treatment as an Employee Stock Purchase Plan. 
  

	9.	CAPITALIZATION ADJUSTMENTS. 

 The limitations set forth in Section 3(e) shall be adjusted, as appropriate, to reflect Capitalization Adjustments. 
  

	10.	OFFERING SUBJECT TO PLAN. 

 Each Offering is subject to all the provisions of the Plan, and the provisions of the Plan are hereby made a part of the Offering. The Offering is further
subject to all interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of an Offering and those of the Plan (including
interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan), the provisions of the Plan shall control. 
 * * * *

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