Document:

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                                                                   EXHIBIT 10.47

February 27, 2004

Re:   ACCELERATION BENEFITS AGREEMENT

Dear Emile:

This letter will memorialize our agreement (the "Agreement") as to certain
acceleration benefits to which you will be entitled upon termination of your
employment by Epimmune Inc. (the "Company") under the circumstances described in
this Agreement.

We agree that you are employed by the Company as an "at-will" employee and that
either you or the Company has the right at any time to terminate your employment
with the Company, with or without cause or advance notice, for any reason or for
no reason.

For purposes of this Agreement, the following terms will have the meanings set
forth below:

      "BENEFIT" means any benefit received or to be received by you pursuant to
      this Agreement.

      "CAUSE" means (i) willful misconduct by you including, but not limited to,
      dishonesty which materially and adversely reflects upon your ability to
      perform your duties for the Company, (ii) your conviction of, or the entry
      of a pleading of guilty or nolo contendere by you to, any crime involving
      moral turpitude or any felony, (iii) fraud, embezzlement or theft against
      the Company, (iv) a material breach by you of any material provision of
      the Proprietary Information and Inventions Agreement between you and the
      Company, or (v) your willful and habitual failure to attend to your duties
      as assigned by the Board of Directors or officers of the Company to whom
      you report and, in the case of clauses (iv) and (v) above, which breach,
      misconduct or non-performance is not cured by you within thirty (30) days
      after you receive written notice from the Company of such breach,
      misconduct or non-performance.

      "CHANGE IN CONTROL" means (i) a dissolution or liquidation of the Company;
      (ii) a sale or other disposition of all or substantially all of the assets
      of the Company; (iii) a merger or consolidation in which the Company is
      not the surviving corporation and in which beneficial ownership of
      securities of the Company representing at least fifty percent (50%) of the
      combined voting power entitled to vote in the election of Directors has
      changed; (iv) an acquisition by any person, entity or group within the
      meaning of Section 13(d) or 14(d) of the Securities Exchange Act, or any
      comparable successor provisions (excluding any employee benefit plan, or
      related trust, sponsored or maintained by the Company or subsidiary of the
      Company or other entity controlled by the Company) of the beneficial
      ownership (within the meaning of Rule 13d-3 promulgated under the Exchange
      Act, or comparable successor rule) of securities of the Company
      representing at least fifty percent

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      (50%) of the combined voting power entitled to vote in the election of
      Directors.

      "COMPANY" for the purposes of this Agreement shall include the Company's
      successor if a Change in Control occurs.

      "GOOD REASON" means termination by you of your employment with the Company
      upon not less than thirty (30) days' prior written notice to the Company
      (to allow the Company to remedy any basis for Good Reason termination) as
      a result of (i) a substantial diminution in the scope of your duties and
      authority within the Company which results in the assignment of duties and
      responsibilities of materially lesser status, dignity and character than
      your duties and responsibilities on the date of execution of this
      Agreement, which is not the result of your failure to attend to and/or
      successfully complete your duties and responsibilities, (ii) any reduction
      in your base salary as initially set forth herein or as may be increased
      from time to time, or (iii) relocation of your office, without your
      consent, to a location that is more than thirty (30) miles from the
      Company's current corporate headquarters.

If, within 365 days following the occurrence of a Change in Control, your
employment is terminated by the Company without Cause or you voluntarily
terminate your employment for Good Reason, then with respect to any Company
stock options granted to you after December 9, 2003, the vesting and
exercisability of such stock options will be immediately accelerated as to 100%
of the then unvested shares subject to such stock options, so that all such
unvested shares will be immediately vested and exercisable as of the date of
your termination.

In the event that any Benefit provided for in this Agreement would (i)
constitute "parachute payments" within the meaning of Section 280G of the
Internal Revenue Code of 1986, as amended (the "Code"), and (ii) but for this
subsection would be subject to the excise tax imposed by Section 4999 of the
Code (the "Excise Tax"), then, the Benefit to which you are entitled pursuant to
this Agreement shall be either:

   (a)  Provided to you in full, or

   (b)  Provided  to you at such  lesser  extent  that  would  result  in no
   portion of the Benefit being subject to the Excise Tax,

whichever of the foregoing amounts, when taking into account applicable federal,
state, local and foreign income and employment taxes, the Excise Tax, and any
other applicable taxes, results in the receipt by you, on an after tax basis, of
the greatest amount of the Benefit, notwithstanding that all or some portion of
the Benefit may be taxable under the Excise Tax. Unless you and the Company
otherwise agree in writing, any determination required under this subsection
shall be made in writing in good faith by an accountant selected by you. In the
event of a reduction of the Benefit under this Agreement or otherwise provided
to you, you shall be given the choice of which to reduce. For purposes of making
the calculations required by this subsection, the accountant that you select may
make reasonable assumptions and approximations concerning applicable taxes and
may rely on reasonable, good faith interpretations concerning the application of
the Code, and other applicable legal authority. You and the Company shall
furnish your accountant such information and documents as he may reasonably
request in order to make a determination under this subsection.

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This Agreement may be changed or terminated only upon the mutual written consent
of the Company and you. Nothing in this Agreement will prevent or limit your
continuing or future participation in any benefit, bonus, incentive or other
plans, programs, policies or practices provided by the Company and for which you
may otherwise qualify, nor will anything herein limit or otherwise affect such
rights as you may have under any stock option or other agreements with the
Company.

If either party hereto brings any action to enforce such party's rights
hereunder, the prevailing party in any such action will be entitled to recover
such party's reasonable attorneys' fees and costs incurred in connection with
such action.

This Agreement constitutes the entire agreement between you and the Company. It
is entered into without reliance on any promise or representation other than
those expressly contained herein. All questions concerning the construction,
validity and interpretation of this Agreement will be governed by the law of the
State of California.

Very truly yours,

EPIMMUNE INC.

/s/ Robert De Vaere
--------------------------------------
Robert De Vaere
Chief Financial Officer

Agreed and Accepted:

/s/ Emile Loria
--------------------------------------
Dr. Emile Loria

Dated:  February 27, 2004

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                                                                   EXHIBIT 10.45

             FIRST AMENDMENT TO PURCHASE, SALE AND LICENSE AGREEMENT

         THIS FIRST AMENDMENT is entered into as of the 31st day of January,
2004, by and between Planet Polymer Technologies, Inc., a California corporation
("Planet"), and Ryer Enterprise LLC, a Nevada limited liability company
("Ryer").

                                    RECITALS

         A.       The parties have heretofore entered into that certain
Purchase, Sale and License Agreement (the "Agreement"). Pursuant to the
Agreement, Ryer has been making payments to Planet in accordance with its terms.

         B.       Ryer has requested that the payments due under the Agreement
on February 1, 2004, and March 1, 2004, be deferred, and Planet is willing to
defer the due date of said payments until June 1, 2005, and July 1, 2005,
respectively, provided that Ryer makes an additional payment of $4,600.00 on
August 1, 2005.

         C.       The parties desire to amend the Agreement to provide for the
foregoing deferments and additional payment.

         NOW, THEREFORE, the parties agree as follows:

         1.       The Agreement is hereby amended by deferring the due date of
the payment of Eleven Thousand Five Hundred Dollars ($11,500.00) originally due
under the Agreement on February 1, 2004, until June 1, 2005. The Agreement is
hereby further amended by deferring the due date of the payment of Eleven
Thousand Five Hundred Dollars ($11,500.00) originally due under the Agreement on
March 1, 2004, until July 1, 2005. All other payments due under the Agreement
shall not be affected and shall be due on their originally scheduled due dates,
with the next scheduled payment being due on April 1, 2004.

         2.       In consideration of the foregoing deferments, Ryer shall pay
to Planet on August 1, 2005, the sum of Four Thousand Six Hundred Dollars
($4,600.00). In further consideration of the foregoing deferments, Ryer agrees
that its sole remedy for any obligation of Planet under the Agreement to Ryer,
including, without limitation, any right to indemnification from Planet, shall
be Ryer's right to setoff, which right of setoff shall be applied first to
monthly installments due from Ryer to Planet in the reverse order of when such
installments are due (i.e., a setoff would first be applied against the payment
due August 1, 2005) and then against royalty payments.

         3.       The Secured Promissory Note, dated May 1, 2003 (the "Note"),
that Ryer executed and delivered to Planet to evidence the payments due from
Ryer to Planet under the Agreement, is hereby amended to reflect the foregoing
deferments and additional payment. Planet shall add a notation to the original
Note to indicate that its terms have been modified by this First Amendment.

         4.       This First Amendment may be executed in counterparts. When
each party has executed and delivered identical counterparts, this First
Amendment shall be deemed to be effective. The delivery of a signed counterpart
by facsimile transmission shall be binding upon the signer (nevertheless, each
party agrees to deliver to the other party an original, signed counterpart of
this First Amendment).

         5.       As amended by this First Amendment, the Agreement and the Note
shall continue to be in full force and effect, and are hereby ratified and
confirmed.

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         IN WITNESS WHEREOF, the parties have caused this First Amendment to be
executed by their duly authorized signatories, as of the date first above
written.

                                             Planet Polymer Technologies, Inc.,
                                             a California corporation

                                             By: ______________________________
                                             Name: H. Mac Busby
                                             Its:  President

                                             Ryer Enterprises LLC,
                                             a Nevada limited liability company

                                             By: ______________________________
                                                 Jay Gilbert, Manager

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