Document:

<PAGE>

                                                                     Exhibit 4.1

                             UNITED AUTO GROUP, INC.
                                   AS ISSUER,

                           THE GUARANTORS NAMED HEREIN
                                 AS GUARANTORS,

                                       AND

                         J.P. MORGAN TRUST COMPANY, N.A.
                                   AS TRUSTEE,
                           AS SUCCESSOR IN INTEREST TO
                          BANK ONE TRUST COMPANY, N.A.

                    9 5/8% SENIOR SUBORDINATED NOTES DUE 2012

                          FOURTH SUPPLEMENTAL INDENTURE

                            DATED AS OF MAY 17, 2005

                                       TO

                                    INDENTURE

                           DATED AS OF MARCH 18, 2002

<PAGE>

                          FOURTH SUPPLEMENTAL INDENTURE

THIS FOURTH SUPPLEMENTAL INDENTURE, dated as of May 17, 2005 (this "Fourth
Supplemental Indenture"), to the Indenture (as defined below), among United Auto
Group, Inc., a Delaware corporation (the "Company"), the Guarantors (as defined
in the Indenture), the additional Guarantors listed on Schedule A annexed hereto
(individually, the "Additional Guarantor" collectively, the "Additional
Guarantors") and J.P. Morgan Trust Company, N.A. (as successor in interest to
Bank One Trust Company, N.A.) in its capacity as trustee (the "Trustee").

WHEREAS, each Additional Guarantor has become a Restricted Subsidiary and
pursuant to Section 901 of the Indenture is entering into this Fourth
Supplemental Indenture to thereby become a Guarantor as provided in Article 1013
of the Indenture; and

WHEREAS, pursuant to Section 901(e) of the Indenture, the Company, the
Guarantors, each Additional Guarantor and the Trustee may enter into this Fourth
Supplemental Indenture without the consent of any Holder; and

WHEREAS, all consents and notices required to be obtained and given as
conditions to the execution of this Fourth Supplemental Indenture pursuant to
the Indenture and all other documents relating to the Notes have been obtained
and given;

NOW, THEREFORE, for and in consideration of the premises and the mutual
covenants and agreements hereinafter set forth, the parties hereto agree as
follows:

                      ARTICLE 1: AUTHORIZATION; DEFINITIONS

SECTION 1.01. FOURTH SUPPLEMENTAL INDENTURE.

This Fourth Supplemental Indenture is supplemental to, and is entered into, in
accordance with Section 901(e) of the Indenture, and except as modified, amended
and supplemented by this Fourth Supplemental Indenture, the provisions of the
Indenture are in all respects ratified and confirmed and shall remain in full
force and effect.

SECTION 1.02. DEFINITIONS.

Unless the context shall otherwise require, all terms which are defined in
Section 1.01 of the Indenture shall have the same meanings, respectively, in
this Fourth Supplemental Indenture as such terms are given in said Section 1.01
of the Indenture.

                        ARTICLE 2: ADDITIONAL GUARANTORS

SECTION 2.01. ADDITIONAL GUARANTORS.

Pursuant to Section 1013 of the Indenture, each Additional Guarantor hereby
expressly assumes the obligations of, and otherwise agrees to perform all of the
duties of, a Guarantor under the Indenture, subject to the terms and conditions
thereof.

                            ARTICLE 3: MISCELLANEOUS

SECTION 3.01. EFFECTIVE DATE.

This Fourth Supplemental Indenture shall become effective upon execution and
delivery hereof.

SECTION 3.02. COUNTERPARTS.

This Fourth Indenture may be executed in several counterparts, each of which
shall be an original and all of

<PAGE>

which shall constitute but one and the same instrument.

SECTION 3.03. ACCEPTANCE.

The Trustee accepts the Indenture, as supplemented by this Fourth Supplemental
Indenture, and agrees to perform the same upon the terms and conditions set
forth therein as so supplemented. The Trustee shall not be responsible in any
manner whatsoever for or in respect of the validity or sufficiency of this
Fourth Supplemental Indenture or the due execution by the Company, the
Guarantors or each Additional Guarantor, or for or in respect of the recitals
contained herein, all of which are made solely by the Company.

SECTION 3.04. SUCCESSORS AND ASSIGNS.

All covenants and agreements in this Fourth Supplemental Indenture, by the
Company, the Guarantors, each Additional Guarantor or the Trustee shall bind its
respective successors and assigns, whether so expressed or not.

SECTION 3.05. SEVERABILITY.

In case any provision in this Fourth Supplemental Indenture shall be invalid,
illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.

SECTION 3.06. GOVERNING LAW.

This Fourth Supplemental Indenture shall be governed by and construed in
accordance with the laws of the State of New York, as applied to contracts made
and performed within the State of New York, without regard to principles of
conflict of laws. Each of the parties hereto agrees to submit to the
jurisdiction of the courts of the State of New York in any action or proceeding
arising out of or relating to this Fourth Supplemental Indenture.

SECTION 3.07. INCORPORATION INTO INDENTURE.

All provisions of this Fourth Supplemental Indenture shall be deemed to be
incorporated in, and made part of, the Indenture, and the Indenture, as amended
and supplemented by this Fourth Supplemental Indenture, shall be read, taken and
construed as one and the same instrument.

IN WITNESS WHEREOF, the parties have caused this Fourth Supplemental Indenture
to be duly executed as of the date first above written.

                             UNITED AUTO GROUP, INC.

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Executive Vice President -
                           Finance

Attest: /s/ Robert H. Kurnick, Jr.
        ---------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Executive Vice President and
               General Counsel

<PAGE>

                          UAG NORTHEAST BODY SHOP, INC.
                      LANDERS UNITED AUTO GROUP NO. 2, INC.
                               UAG SOUTHEAST, INC.
                                UAG DULUTH, INC.
                            UNITED NISSAN, INC. (GA)
                             PEACHTREE NISSAN, INC.
                               UAG TEXAS II, INC.
                                 UAG EAST, INC.
                              PALM AUTO PLAZA, INC.
                         FLORIDA CHRYSLER PLYMOUTH, INC.
                              WEST PALM NISSAN, IN.
                           NORTHLANK AUTO FINISH, INC.
                                JS IMPORTS, INC.
                            WEST PALM AUTO MALL, INC.
                        AUTO MALL PAYROLL SERVICES, INC.
                               UAG CAROLINA, INC.
                          REED-LALLIER CHEVROLET, INC.
                       MICHAEL CHEVROLET-OLDSMOBILE, INC.
                            GENE REED CHEVROLET, INC.
                               UAG GOLDSBORO, INC.
                           UAG KISSIMMEE MOTORS, INC.
                          UNITEDAUTOCARE PRODUCTS, LLC
                        UNITED AUTO FOURTH FUNDING, INC.
                         UNITED AUTO FIFTH FUNDING, INC.
                            UAG FINANCE COMPANY, INC.
                        ATLANTIC AUTO FUNDING CORPORATION
                    ATLANTIC AUTO SECOND FUNDING CORPORATION
                     ATLANTIC AUTO THIRD FUNDING CORPORATION
                          UAG HOUSTON ACQUISITION, LTD.
                        UAG INTERNATIONAL HOLDINGS, INC.
                                 UAG REALTY, LLC
                            UNITED AUTO FINANCE, INC.
                             UAG CONNECTICUT I, LLC
                           UAG ATLANTA IV MOTORS, INC.
                             UAG TULSA HOLDINGS, LLC

                           /s/ James R. Davidson
                    By: ------------------------------------
                    Name:  James R. Davidson
                    Title: Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Secretary

<PAGE>

                                 UAG CHCC, INC.
                                    LRP, LTD.
                             DIFEO PARTNERSHIP, INC.
                                UAG HUDSON, INC.
                              SOMERSET MOTORS INC.
                            LANDERS AUTO SALES, INC.
                           LANDERS BUICK-PONTIAC, INC.
                            LANDERS FORD NORTH, INC.
                            UNITED NISSAN, INC. (TN)
                               SA AUTOMOTIVE, LTD.
                               SL AUTOMOTIVE, LTD.
                                SUN MOTORS, LTD.
                        SCOTTSDALE MANAGEMENT GROUP, LTD.
                              SAU AUTOMOTIVE, LTD.
                                 SK MOTORS, LTD.
                                  KMT/UAG, INC.
                      RELENTLESS PURSUIT ENTERPRISES, INC.
                             TRI-CITY LEASING, INC.
                               HT AUTOMOTIVE, LTD.
                            WESTBURY SUPERSTORE, LTD.
                      UNITEDAUTO DODGE OF SHREVEPORT, INC.
                           COVINGTON PIKE DODGE, INC.
                          THE NEW GRACELAND DODGE, INC.
                             UAG GRACELAND II, INC.
                              UAG MEMPHIS II, INC.
                              UAG MEMPHIS IV, INC.
                               UAG MEMPHIS V, INC.
                               UAG-CARIBBEAN, INC.
                            DAN YOUNG CHEVROLET, INC.
                          YOUNG MANAGEMENT GROUP, INC.
                               UAG YOUNG II, INC.
                                UAG CLASSIC, INC.
                            CLASSIC AUTO GROUP, INC.
                         CLASSIC MANGEMENT COMPANY, INC.
                              CLASSIC IMPORTS, INC.
                            CLASSIC MOTOR SALES, LLC
                             D. YOUNG CHEVROLET LLC
                              DAN YOUNG MOTORS LLC
                          YOUNG AUTOMOTIVE HOLDINGS LLC
                            EUROPA AUTO IMPORTS, INC.
                              UAG LAKE NORMAN, LLC
                              UAG INDIANAPOLIS, LLC
                           MOTORCARS ACQUISITION, LLC
                          MOTORCARS ACQUISITION II, LLC
                         MOTORCARS ACQUISITION III, LLC
                             SCOTTSDALE FERRARI, LLC
                         UAG OLDSMOBILE OF INDIANA, LLC
                               GOODSON NORTH, LLC
                            GOODSON PONTIAC GMC, LLC
                           GOODSON SPRING BRANCH, LLC
                              UAG NEVADA LAND, LLC
                                UAG CERRIOTS, LLC
                              UAG CONNECTICUT, LLC
                              UAG FAIRFIELD CA, LLC
                              UAG FAIRFIELD CM, LLC

<PAGE>

                              UAG FAIRFIELD CP, LLC
                           UAG LANDERS SPRINGDALE, LLC
                           UAG MENTOR ACQUISITION, LLC
                           UAG MICHIGAN CADILLAC, LLC
                          UAG MICHIGAN PONTIAC-GMC, LLC
                              UAG MICHIGAN T1, LLC
                              UAG MICHIGAN TMV, LLC
                               UAG PHOENIX VC, LLC
                                 UAG SPRING, LLC
                          UNITED RANCH AUTOMOTIVE, LLC
                               UAG CHEVROLET, INC.
                        BRETT MORGAN CHEVROLET-GEO, INC.
                                    HBL, LLC
                          MOTORCARS ACQUISITION IV, LLC
                                UAG NANUET I, LLC
                               UAG NANUET II, LLC
                          NISSAN OF NORTH OLMSTED, LLC
                               LANDERS NISSAN, LLC
                             UAG FAYETTEVILLE I, LLC
                            UAG FAYETTEVILLE II, LLC
                            UAG FAYETTEVILLE III, LLC

                        /s/ James R. Davidson
                    By: ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

<PAGE>

                            DIFEO HYUNDAI PARTNERSHIP
                            DIFEO NISSAN PARTNERSHIP
                 DIFEO CHRYSLER PLYMOUTH JEEP EAGLE PARTNERSHIP
                            DIFEO LEASING PARTNERSHIP
                            DANBURY AUTO PARTNERSHIP
                            DIFEO TENAFLY PARTNERSHIP
                                 OCT PARTNERSHIP
                            HUDSON MOTORS PARTNERSHIP
                          COUNTY AUTO GROUP PARTNERSHIP
                           SOMERSET MOTORS PARTNERSHIP

                           BY: DIFEO PARTNERSHIP, INC.
                                A general partner

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                            SHANNON AUTOMOTIVE, LTD.

                      BY: UAG TEXAS, LLC, A GENERAL PARTNER

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
       -------------------------------------
       Name:  Robert H. Kurnick, Jr.
       Title: Secretary

<PAGE>

                            CLASSIC ENTERPRISES, LLC
                       CLASSIC NISSAN OF TURNERSVILLE, LLC

                          BY: UAG CLASSIC, INC., MEMBER

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                               LANDERS FORD, INC.
                            NATIONAL CITY FORD, INC.
                            CENTRAL FORD CENTER, INC.
                            PIONEER FORD SALES, INC.

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        ---------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

<PAGE>

                           CLASSIC TURNERSVILLE, INC.
                                GMG MOTORS, INC.
                                    KMPB, LLC
                             SCOTTSDALE JAGUAR, LTD.
                           UNITED AUTO LICENSING, LLC
                                    CJNS, LLC
                                    LMNS, LLC
                                   UAG VK, LLC

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -----------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                          UAG TURNERSVILLE REALTY, LLC

                           /s/ James R. Davidson
                    By: ------------------------------------
                    Name:  James R. Davidson
                    Title: Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -----------------------------------
        Name: Robert H. Kurnick, Jr.
        Title: Secretary

                              UAG MICHIGAN H1, LLC
                            LATE ACQUISITION II, LLC
                                UAG TULSA VC, LLC
                           UAG MICHIGAN HOLDINGS, LLC
                              UAG WEST BAY AM, LLC
                              UAG WEST BAY IA, LLC
                             UAG WEST BAY IAU, LLC
                              UAG WEST BAY IB, LLC
                              UAG WEST BAY II, LLC
                              UAG WEST BAY IL, LLC
                              UAG WEST BAY IM, LLC
                              UAG WEST BAY IP, LLC
                              UAG WEST BAY IV, LLC
                              UAG WEST BAY IW, LLC
                              UAG WEST BAY FM, LLC
                          UAG TURNERSVILLE MOTORS, LLC
                               UAG CENTRAL NJ, LLC
                               UAG ROYAL PALM, LLC

<PAGE>

                         UAG CENTRAL FLORIDA MOTORS, LLC
                          MOTORCARS ACQUISITION V, LLC
                          BEDFORD COLLISION CENTER, LLC
                                    PMRC, LLC
                             UAG CITRUS MOTORS, LLC

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        --------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                             LATE ACQUISITION I, LLC

                           BY: UNITED AUTO GROUP, INC.
                                     MEMBER

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Executive Vice President -
                           Finance

Attest: /s/ Robert H. Kurnick, Jr.
        ----------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Executive Vice President,
               General Counsel

<PAGE>

                                WTA MOTORS, LTD.
                          BY: LATE ACQUISITION II, LLC
                                 GENERAL PARTNER

                    By: /s/ James R. Davidson
                        ------------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                                  UAG GN, LTD.
                                  UAG GW, LTD.
                                  UAG GD, LTD.

                        BY: UAG HOUSTON ACQUISITION, LTD.
                                 GENERAL PARTNER
                             BY: UAG TEXAS II, INC.
                                 GENERAL PARTNER

                    By: /s/ James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

<PAGE>

                               UAG CAPITOL, INC.
                                UAG CLOVIS, INC.
                                UAG MARIN, INC.
                              UAG LOS GATOS, INC.
                              UAG SUNNYVALE, INC.
                               UAG GAVILAN, INC.
                               SIGMA MOTORS, INC.

                    By: /s/ James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                                 UAG WEST, LLC
                                 UAG TEXAS, LLC

                    By: /s/ James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        ----------------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                               UAG TORRANCE, INC.

                    By: /s/ James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

<PAGE>

                  UNITED AUTO SCOTTSDALE PROPERTY HOLDINGS, LLC
                               UAG ATLANTA H1, LLC
                               UAG NORTHEAST, LLC
                             LANDERS AUTO SALES, LLC
                              UAG MICHIGAN H2, LLC
                                FRN OF TULSA, LLC

                    By: /s/James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                              UAG WEST BAY IN, LLC
                             UNITED FORD SOUTH, LLC
                             UNITED FORD NORTH, LLC
                          UNITED FORD BROKEN ARROW, LLC
                             DEALER ACCESSORIES, LLC
                               UAG TULSA JLM, LLC

                    By: /s/ James R. Davidson
                        ----------------------------------
                    Name:  James R. Davidson
                    Title: Assistant Treasurer

Attest: /s/ Robert H. Kurnick, Jr.
        -------------------------------------
        Name:  Robert H. Kurnick, Jr.
        Title: Assistant Secretary

                   J.P. MORGAN TRUST COMPANY, NA, AS TRUSTEE,
                          AS SUCCESSOR IN INTEREST TO
                          BANK ONE TRUST COMPANY, N.A.

                    By: /s/ George N. Reaves
                        ----------------------------------
                    Name:  George N. Reaves
                    Title: Vice President

<PAGE>

STATE OF NEW JERSEY )
                    )ss.:
COUNTY OF HUDSON    )

      On the 17th day of May, 2005 before me personally came James R. Davidson
to me known, who, being by me duly sworn, did depose and say that he is employed
at One Harmon Plaza, 9th Floor, Secaucus, NJ 07094, that he is the Executive
Vice President - Finance of United Auto Group, Inc., a corporation described in
and which executed the foregoing instrument; that he holds the positions
identified on Annex I hereto with respect to each of the guarantors identified
on Annex I hereto, each of which has executed the foregoing instrument; and that
he signed his name thereto pursuant to the respective authority of the Board of
Directors of United Auto Group, Inc. and such guarantors that are corporations,
the Boards of Directors of the general partner of such guarantors that are
limited partnerships, and the members or managers of such guarantors that are
limited liability companies.

                                               (NOTORIAL SEAL)

                                               /s/ Ellen A. Shyne
                                               ---------------------------------
                                                                   Notary Public

                                                                  Ellen A. Shyne
                                                                   Notary Public
                                                             State of New Jersey
                                               My Commission Expires Aug 3, 2008

<PAGE>

                                   Schedule A

UAG West Bay IN, LLC
United Ford South, LLC
United Ford North, LLC
United Ford Broken Arrow, LLC
Dealer Accessories, LLC
UAG Tulsa JLM, LLC

<PAGE>

ANNEX I

<TABLE>
<CAPTION>
      GUARANTOR                 POSITION OF JAMES R. DAVIDSON
      ---------                 -----------------------------
<S>                             <C>
UAG West Bay IN, LLC                 Assistant Treasurer
United Ford South, LLC               Assistant Treasurer
United Ford North, LLC               Assistant Treasurer
United Ford Broken Arrow, LLC        Assistant Treasurer
Dealer Accessories, LLC              Assistant Treasurer
UAG Tulsa JLM, LLC                   Assistant Treasurer
</TABLE>exv10w49

 

Exhibit 10.49

AMENDMENT NO.12

TO SHAREHOLDERS’ AGREEMENT OF KIRIN-AMGEN

AMENDMENT NO.12 (this “Amendment”) dated January 31, 2001, to the Shareholders’ Agreement of
Kirin-Amgen dated May 11, 1984 (as amended, the “Shareholders’ Agreement”) among Kirin Brewery Co.,
Ltd., a Japanese corporation with principal offices located at 10-1, Shinkawa 2-chome, Chuo-ku,
Tokyo, 104-8288, Japan (“Kirin”), Amgen Inc., a Delaware corporation with principal offices located
at One Amgen Center Drive, Thousand Oaks, California 91320 (“Amgen”) and Kirin-Amgen, Inc., a
Delaware corporation with principal offices located at c/o Amgen Europe AG, Grabenhof, 6010 Kirens,
Switzerland (“Kirin-Amgen”).

WITNESSETH:

     WHEREAS, Kirin, Amgen and Kirin-Amgen entered into RESEARCH, DEVELOPMENT AND TECHNOLOGY
DISCLOSURE AGREEMENT: TPO/MGDF (hereinafter, the “Research Agreement”) and TPO/MGDF TECHNOLOGY
TRANSFER AGREEMENT, (hereinafter, the “Technology Agreement”; collectively these two agreements
shall be referred to as the “Agreements”) and Kirin and Amgen each entered into a TPO/MGDF LICENSE
AGREEMENT with Kirin-Amgen (hereinafter respective called the “Kirin License Agreement” and the
“Amgen License Agreement”), all these agreements dated December 9, 1994 and effective as of June
14, 1994.

     WHEREAS, this Amendment sets forth certain agreement between the Parties with respect to the
manufacture, production and worldwide commercial sale of human diagnostics and reagents relating to
TPO/MGDF (as defined in the Agreements).

     WHEREAS, this Amendment also sets forth certain agreement between the Parties with respect to
the prior arrangements implemented with respect to the sale of human diagnostics and reagents
relating to Epo and G-CSF.

     NOW, THEREFORE, in consideration of the mutual covenants expressed herein and other good and
valuable consideration, the parties agree as follows:

	1.	 	COMMERCIAL REAGENT: EXPANSION OF BUSINESS OPPORTUNITIES

     1.01 License to Kirin-Amgen. The Parties hereto agree that Kirin and Amgen each grant
Kirin-Amgen a royalty-free, exclusive and worldwide license to develop, make, have made, use, sell
and have sold human diagnostics and commercial reagents, including but not limited to a reagent,
kit or service using such reagent and/or kit, relating to TPO/MGDF (“TPO/MGDF Commercial Reagent”)
for uses not included within Human Pharmaceutical Use (as defined in the Agreements) and not included as veterinary or animal uses (the “Field of Use”). The Parties
agree that the right to develop, make, have made, use, sell and have sold TPO/MGDF Commercial
Reagent shall include the right to develop, make, have made, use, sell and have sold antibodies

-1-

 

relating to the TPO/MGDF to the extent required for use in TPO/MGDF Commercial Reagent within the
Field of Use.

     1.02 License to Kirin and Amgen. The Parties hereto agree that Kirin-Amgen grants
Kirin and Amgen, respectively, a royalty-free, co-exclusive (with Amgen and Kirin only) and
worldwide license to develop, make, have made, use, sell and have sold the TPO/MGDF Commercial
Reagent in the Field of Use.

     1.03 Territories. Amgen’s right granted by Kirin-Amgen under the Amgen License
Agreement shall be royalty-free, worldwide and co-exclusive with Kirin with respect to the TPO/MGDF
Commercial Reagent. Kirin’s right granted by Kirin-Amgen under the Kirin License Agreement shall
be royalty-free, worldwide and co-exclusive with Amgen with respect to the TPO/MGDF Commercial
Reagent.

	2.	 	FIRST COMMERCIAL SALE

     The Parties hereto agree that the sale of TPO/MGDF Commercial Reagent shall not be considered
to be the First Commercial Sale (as defined in the Research Agreement). Except for the purpose of
the sale or promotion of the TPO/MGDF Commercial Reagent, neither Kirin nor Amgen shall provide
TPO/MGDF to third parties in any country outside of their respective territories (as defined as
“Kirin Territory” and “Amgen Territory” in the Agreements) without prior written consent of the
other party, prior to the First Commercial Sale of TPO/MGDF by the other party or its affiliates or
licensees in that country.

	3.	 	CONSISTENCY WITH SHAREHOLDERS’ AGREEMENT; RATIFICATION

     3.01 Consistency. The rights and obligations of the Parties hereto with respect to
this Amendment No. 12 as an expansion of Kirin-Amgen’s business opportunities are otherwise
consistent with the Shareholders’ Agreement.

     3.02 Ratification. All of the terms and conditions of the Shareholders’ Agreement as
amended by this Amendment No.12 are hereby ratified and confirmed in all respects.

	4.	 	FURTHER INSTRUMENTS

     The Parties hereto agree to perform any and all further acts and execute and deliver any and
all further documents and/or instruments which may be reasonable or necessary to carry out the
provisions of this Amendment.

-2-

 

	5.	 	RATIFICATION OF PAST ARRANGEMENTS WITH RESPECT TO HUMAN DIAGNOSTICS AND COMMERCIAL REAGENT SALES OF EPO AND G-CSF

     The parties agree and acknowledge and hereby formally ratify the following:

     A. Effective as of January 1, 1991: Amgen shall have exclusive, royalty-free rights to sell
human diagnostics and commercial reagents of EPO throughout the world with the exception of Japan;
Kirin shall have the exclusive royalty-free rights to sell human diagnostics and commercial
reagents of EPO within Japan. Except as modified herein, the terms of such agreement are set forth
in Amendment No. 1 to the Shareholders’ Agreement and the relevant exhibits thereto.

     B. Effective as of January 1, 1991: Amgen shall have exclusive, royalty-free rights to sell
human diagnostics and commercial reagents of G-CSF within the United States, Europe, Australia,
Canada and New Zealand; Kirin shall the exclusive royalty-free rights to sell human diagnostics and
commercial reagents of G-CSF within Japan, Korea, Taiwan and the PRC; Kirin and Amgen shall share
co-exclusive, royalty-free rights to sell human diagnostics and commercial reagents of G-CSF for
the rest of the world.

     C. There will be no alteration, adjustment or correction in the past payment (or lack of
payment) of any royalty related to sales of commercial reagents or human diagnostics for EPO or
G-CSF by either Party prior to the execution of this document. The Parties ratify all previous
activity in the area of accounting for past sales.

     D. Except as specifically set forth above, this subsection does not alter or amend any
existing agreement involving Kirin, Amgen and/or Kirin-Amgen with respect to human diagnostics
and/or commercial reagents.

     IN WITNESS WHEREOF, the Parties hereto have caused this Amendment to be executed by their duly
authorized representatives in the manner legally binding on them.

	 	 	 	 	 	 	 	 	 	 	 	 	 
	Kirin Brewery Co., Ltd.	 	 	 	Amgen Inc.	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	/s/ Koichiro Aramaki	 	 	 	/s/ Craig Brooks	 	 	 	 	 	 
	 	 	 	 	 
	By: Koichiro Aramaki

	 	 	 	By: Craig Brooks	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 	 	 	 	 
	Title:

	 	President, Pharmaceutical Division
	 	 	 	Title: Vice President, APLA	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	Kirin-Amgen, Inc.	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 
	/s/ Katsuhiko Asano	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 
	By: Katsuhiko Asano, Ph.D.	 	 	 	 	 	 	 	 	 	 
	Title: Chairman	 	 	 	 	 	 	 	 	 	 

-3-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00088-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00088-of-00352.parquet"}]]