Document:

EX-10.31

 Exhibit 10.31 

FIRST AMENDMENT TO STANDARD RENTAL LEASE, STORAGE LEASE AND SIGNAGE LEASE 

TO EXPAND and EXTEND TERM 

THIS FIRST AMENDMENT TO STANDARD RENTAL LEASE, STORAGE LEASE AND SIGNAGE LEASE (this “Amendment”) is made and entered into as of the
of January 30, 2014 by and between AG/Touchstone TP, LLC., a (“Lessor”) and DermTech International, a California corporation (“Lessee”). 

Recitals 

A.        Lessor and Lessee are the original parties to that certain Standard Rental
Office Lease, dated as of January 25, 2013, (the “Lease”) for the certain premises commonly known as 11099 North Torrey Pines Road, Suite 100, San Diego, CA 92037 (the “Premises”) see attached Exhibit A. In addition to the
Lease there are separate agreements signage and storage at the Property. 

B.        Lessor and Lessee are the original parties to that certain Storage Lease,
dated as of April 15, 2013 (the “Storage Lease”), and that certain Signage Lease, dated as of April 15, 2013 (the “Signage Lease”). 

C.        Lessor and Lessee now desire to amend and modify certain terms and
conditions of the Lease, Storage Lease and Signage Lease as further set forth below. Unless otherwise expressly provided, all defined terms used in this Amendment shall have the same meanings given to them in the Lease. 

Agreements 

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants, conditions and agreements contained herein, and
for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Lessor and Lessee hereby agree as follows: 
  

	 	1.	 Expansion: Suite 130 in the amount of 1,092 rentable square feet,
(the “Expansion Space”). Total new square footage leased in suite 100 and 130 shall be 9,589 rentable square feet, the Premises. The Expansion Space consist of four offices and one conference room at the northwest corner of the Property on
the ground floor as depicted in Exhibit A. 

  

	 	2.	 Term: The Term shall be extended by thirty-seven (37) months commencing on
January 1, 2014, the Commencement Date and expire on January 31, 2017. The respective terms of the Signage Lease and the Storage Lease are hereby extended to be coterminous with the Term of the Lease, unless either is sooner terminated
pursuant to its terms. 

  

	 	3.	 Base Monthly Rental Amount: Effective on the Commencement Date the Base Monthly
Rental shall be $14,150 for month 1, $27,329 per month, months 2 thru 13 $28,149 per month, months 14 thru 25 and $28,995 per month, months 26 thru 37 of the Term. The Storage and Signage Lease rent is in addition to the Base Monthly Rental above
pursuant to the terms of those respective Leases.  

  

	 	4.	 Option to Extend. Lessee shall have the option to extend the term of this Lease for an
additional thirty-six (36) months (“Extension Term”) beginning upon the expiration of this Term as extended by Paragraph 2 above, provided that Lessee is not in default at the time of exercise
of the option beyond applicable notice and cure periods and Lessee gives Lessor written notice of its intention to exercise this option to extend at least nine months prior to expiration the Term. Upon giving the extension notice, the Lease shall be
extended without execution or delivery of any other document, with the same force and effect as if the Extension Term had originally been included in the Term. All of the terms, covenants and conditions of the Lease shall continue in full force and
effect during the Term, except that the Base Rent to be paid by Lessee to Lessor during the Extension Term shall be the greater of (1) $29,865/month (“the Guaranteed Minimum Rent”) or (2) Market Rental Rate (defined below).As used
herein, the term “Market Rental Rate” shall mean the rate that is prevailing as of the commencement of the first year of the Extension Term for comparable space in a comparable building

  
 1 

	 	 
in the Torrey Pines area, taking into consideration the size and age of and improvements in the Premises, the three-year term of the Extension Term, and other relevant factors. Market Rental Rate
shall be determined as follows: 

 4.1    By mutual agreement
between Lessor and Lessee evidenced in a writing signed by each and mutually delivered or 

4.2    If Lessor and Lessee have not agreed upon the Market Rental Rate Five months
prior to the commencement of the first Lease Year of the Extension Term, then either Lessor or Lessee may submit the issue of Market Rental Rate to determination by arbitration. The venue for the arbitration shall be San Diego County and, with
respect to the conduct of the arbitration, the following shall apply: 
 4.2.1    At
least three weeks in advance of the date for the commencement of the arbitration hearing, Lessor and Lessee shall exchange with each other (1) the name, address, and qualifications of any appraiser, broker, or other expert intended to be called
at the time of the arbitration (each, an “Expert”), (2) any reports and/or data relied upon by the Expert in connection with forming an opinion as to Market Rental Rate, and (3) a statement as to each party’s determination
of the Market Rental Rate (“MRR Statement”) (i.e., Lessor shall give to Lessee Lessor’s determination of the Market Rental Rate and vice-versa). 

4.2.2    For a period of 10 days following the exchange of the MRR Statements,
either party may accept the Market Rental Rate stated in the other party’s MRR Statement, and, in such event, the accepted amount will become the Rent for the Extension Term (e.g., if Lessor delivered to Lessee timely written notice of
acceptance of Lessee’s determination of Market Rental Rate as provided in Lessee’s MRR Statement, then the amount shown on Lessee’s MRR Statement would become the Rent for the Extension Term). 

4.2.3    If neither party accepts the other party’s determination of Market Rental
Rate, then the arbitration shall be conducted before a single arbitrator pursuant to Code of Civil Procedure sections 1280 et seq. At least five days prior to the date set for the hearing for the arbitration, each party shall (1) make available
for an oral deposition any Expert whose testimony is expected to be given at the time of the arbitration and (2) deliver to the other party all exhibits that are intended to be entered into evidence at the time of the arbitration. 

4.2.4    Except as provided below, each party shall bear its own attorney’s and
Expert’s fees. Except as provided below, each party shall share equally any administrative fees and the reasonable hourly fees owed to the arbitrator. Notwithstanding the foregoing, if the amount of the Market Rental Rate stated in
Lessee’s MRR Statement is less than 95 percent of the Market Rental Rate determined by the arbitrator, then the arbitrator may, in the arbitrator’s discretion, assess against Lessee costs incurred by Lessor in connection with the
arbitration, including, without limitation, reasonable attorney’s fees, Expert’s fees, arbitrator’s fees and administration fees. If the amount of the Market Rental Rate stated in Lessor’s MRR Statement is greater than
105 percent of the Market Rental Rate determined by the arbitrator, then the arbitrator may, in the arbitrator’s discretion, assess against the Lessor costs incurred by Lessee in connection with the arbitration, including, without
limitation, reasonable attorney’s fees, Expert’s fees, arbitrator’s fees and administration fees. 

4.2.5    Pending determination of the Market Rental Rate for the Extension Term, Lessee
shall pay to Lessor monthly Rent in an amount equal to the Guaranteed Minimum Rent increased by 3%. If the Market Rental Rate is greater than the Guaranteed Minimum Rent, then, within 30 days following the arbitrator’s decision determining
the amount of the Market Rental Rate, Lessee shall pay to Lessor the difference between (1) the Base Rent that should have been paid during the Extension Term based upon the Market Rental Rate and (2) the actual amount of the Base Rent
paid by Lessee during the Extension Term. 
 4.2.6    The Base Rent for each
subsequent Lease Year of the Extension Term will be equal to the amount derived by multiplying the Base Rent for the prior Lease Year of the Extension Term by 1.03. By way of example, if the Base Rent for the first Lease Year of the Extension Term

  
 2 

 
were determined to be $31,000, the Base Rent for the second and third Lease Years of the Extension Term would be $31,930 and $32,889. 

4.2.7    As used herein, the term “Lease Year” shall mean each 12-month period commencing on the Commencement Date if the Commencement Date is the first day of a calendar month, but otherwise on the first day of the calendar month immediately next following the calendar month
in which the Commencement Date occurs, and ending on the last day of the twelfth month thereafter; however, the first Lease Year shall include any partial month in which the Commencement Date occurs if the Commencement Date occurs on a day other
than the first day of the month. 
 4.2.8    The Option is personal to the Lessee and
any Tenant Affiliate and may not be assigned or transferred (other than to a Tenant Affiliate) without the Lessor’s written consent. 
  

	 	5.	 Lessee’s Share of Operating Expenses: Effective on the Commencement Date,
Lessee’s Share of Operating Expenses shall be increased to 10.4%. 

  

	 	6.	 Lessor’s Work: Lessor shall provide tenant improvements as mutually agreed to by
the Parties in the Premises in an amount not to exceed $20,000. The completion of the Lessor’s Work shall not affect the Commencement Date. Lessor shall cause to be prepared an estimate of the total cost of the Lessor’s Work (the
“Cost Estimate”). Notwithstanding anything to the contrary herein, if the Cost Estimate exceeds $20,000, Lessee’s obligation to pay for the cost of the Lessor’s Work shall be limited to the amount by which the Cost Estimate
exceeds Lessor’s $20,000 contribution, and Lessor shall be solely liable for any costs in excess of the Cost Estimate. Upon Lessee’s approval of the Cost Estimate, Lessee shall deposit with the Lessor the amount over $20,000. By way of
example, if the Cost Estimate is $30,000 and it is approved by Lessee, than Lessee shall deposit $10,000 with Lessor for its share of the tenant improvements. 

 

	 	7.	 Notice Address: The Notice Address for Lessor and Touchstone Investments is changed to
[●]. 

  

	 	8.	 Excluded Operating Expenses. “Operating Expenses” shall not include
and Lessee shall in no event have any obligation to perform or to pay directly, or to reimburse Lessor for, all or any portion of the following: (a) costs incurred in connection with the presence of any Hazardous Material, except to the extent
caused by the release or emission of the Hazardous Material in question by Lessee; (b) earthquake insurance deductibles. As used in this section, “Hazardous Material” shall mean any material that is now or hereafter regulated by any
governmental authority which poses a hazard to the environment or human health. 

  

	 	9.	 Waiver of Subrogation. The words “Without affecting any other right or
remedies” in the first sentence of Section 8.6 of the Lease shall be deleted and replaced with the words “Notwithstanding anything to the contrary in this Lease”. 

 

	 	10.	 Late Charges. The words “5 days” in the third sentence of
Section 13.4 shall be deleted and replaced with the words “5 business days”. 

  

	 	11.	 Miscellaneous. This Amendment is the final expression of, and contains the
entire agreement between, the parties hereto with respect to the subject matter hereof, and this Amendment supersedes all prior agreements, communications or understandings, written or verbal, relating to the subject matter hereof. To the extent
that any terms or conditions of this Amendment are inconsistent with any terms or conditions of the Lease, the terms and conditions of this Amendment shall prevail and control. Except as expressly amended or modified in this Amendment, the terms and
conditions of the Lease shall remain unchanged and in full force and effect. 

 [signature page to follow] 

  
 3 

 IN WITNESS WHEREOF, Lessor and Lessee have entered into this First Amendment
as of the date first above written. 
  

			
	LESSOR:
	
	                   By:
AG Touchstone TP, LLC

	
                    a Delaware limited
liability company

	
	
                       
           By: AG TP Parent, LP

	
                       
         a Delaware limited liability company, its sole member

  

			
	 By: Touchstone Investments, Inc., a California corporation

	
	 ITS: Authorized Signatory

  

	
	 By:  /s/ Gregory A.
Erickson                                        
                                 

	
	 NAME: Gregory A. Erickson

	 TITLE: President

	
	LESSEE:
	 DermTech International, a California corporation

	
	 /s/ John
Dobak                                        
                                         
                

	 NAME: John Dobak

	 TITLE: President/CEO

  
 4 

 EXHIBIT A 

Premises 
  
 

 

  
 5EX-10.32

 Exhibit 10.32 

ASSIGNMENT, CONSENT TO ASSIGNMENT, AND SECOND AMENDMENT TO 

STANDARD MULTI-LESSEE OFFICE LEASE - NET 

This ASSIGNMENT, CONSENT TO ASSIGNMENT, AND SECOND AMENDMENT TO STANDARD MULTI-LESSEE OFFICE LEASE - NET
(“Second Amendment”) is made and entered into as of November 21, 2016, by and between HCP TORREY PINES, LLC, a Delaware limited liability company (“Lessor”), DERMTECH INTERNATIONAL, a
California corporation (“Original Lessee”), and DERMTECH, INC., a Delaware corporation (“Lessee”). Lessor, Original Lessee and Lessee are collectively referred to herein as the
“Parties.” 

R E C I T A L S : 

A.         Lessor (as
successor-in-interest to AG/Touchstone TP, LLC, a Delaware limited liability company) and Lessee are parties to that certain Standard Multi-Lessee Office Lease-Net dated
January 25, 2013 (the “Original Lease”), as amended by that certain Addendum to Lease dated January 25, 2013 (the “Addendum”), as further amended by that
certain First Amendment to Standard Rental Lease, Storage Lease and Signage Lease to Expand and Extend Term dated January 30, 2014 (the “First Amendment,” and together with the Original
Lease and Addendum, collectively, the “Lease”), whereby Lessor leases to Lessee, and Lessee leased from Lessor, that certain 9,589 rentable square feet of space commonly known as Suites 100
and 130 (collectively, the “Premises”) and located on the first (1st) floor of that certain building located at 11099 North Torrey Pines Road, San Diego, California
(the “Building”). 
 B.         Lessor
(as successor-in-interest to AG/Touchstone TP, LLC, a Delaware limited liability company) and Original Lessee are parties to that certain Signage Lease dated April 15, 2013 (the “Signage
Lease”). 
 C.         Original Lessee desires to assign its
right, title and interest in, to and under the Lease and the Signage Lease to Lessee, and Lessee desires to accept such assignment (the “Assignment”), and Original Lessee and Lessee desire to obtain Lessor’s
consent thereto. Lessor is willing to consent to the Assignment upon and subject to all of the terms and conditions hereinafter set forth. 

D.         The Parties also desire to extend the term of the Lease and the Signage
Lease and to otherwise amend the Lease as hereinafter provided. 

A G R E E M E N T : 

NOW, THEREFORE, in consideration of the foregoing recitals and the mutual covenants contained herein, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 

  

					
		 		 	

 1.         Capitalized
Terms. All capitalized terms when used herein shall have the same meaning as is given such terms in the Lease unless expressly superseded by the terms of this Second Amendment. 

2.         Assignment of Lease. Effective as of the date of this Second
Amendment (the “Assignment Date”) Original Lessee shall assign to Lessee all of its right, title and interest in, to and under the Lease and the Signage Lease (including all of Original Lessee’s right, title, and
interest in and to any prepaid Rent as paid by Original Lessee pursuant to the Lease), and Lessee hereby agrees to accept the Assignment, assume all of Original Lessee’s obligations under the Lease, and be bound by all of the provisions thereof
and to perform all of the obligations of the lessee thereunder from and after the Assignment Date. Notwithstanding the Assignment or Lessor’s consent thereto, Original Lessee shall remain fully liable for the performance of all obligations of
the lessee under the Lease, as amended hereby, which arise and accrue on or before the Assignment Date. Original Lessee and Lessee hereby covenant that each will, at any time and from time to time upon request by the other, and without the
assumption of any additional liability thereby, execute and deliver such further documents and do such further acts as such party may reasonably request in order to fully effect the purpose of this Assignment. The terms of this Assignment shall be
binding upon, and shall inure to the benefit of, the Parties and their respective successors, transferees and assigns. 

3.         Lessor Consent to Assignment. Lessor hereby consents to the
Assignment on the terms and conditions set forth in Section 2, above. This Second Amendment shall not constitute a consent to any subsequent subletting or assignment and shall not relieve Lessee or any person claiming under or through
Lessee of the obligation to obtain the consent of Lessor, pursuant to Section 12.1 of the Original Lease, to any future assignment or sublease. In the event of any default of Lessee under the Lease, as amended hereby, Lessor may proceed
directly against Lessee, any guarantors or anyone else liable under the Lease without first exhausting Lessor’s remedies against any other person or entity liable thereon to Lessor. 

4.        Second Extended Term. The Lease is currently scheduled to
expire on January 31, 2017. Notwithstanding the foregoing, Lessor and Lessee hereby agree to extend the term of the Lease by five (5) years and two (2) months (the “Second Extended Term”), to March 31, 2022. The respective term
of the Signage Lease is hereby extended to be coterminous with the Second Extended Term, unless sooner terminated pursuant to its terms. 

5.         Condition of Premises. Except as expressly set forth in the Work Letter
attached hereto as Exhibit A (the “Work Letter”), Lessor shall not be obligated to provide or pay for any improvement work or services related to the improvement of the Premises, and Lessee
shall continue to accept the Premises in its presently existing, “as-is” condition. For purposes of Section 1938 of the California Civil Code, Lessor hereby discloses to Lessee, and Lessee hereby
acknowledges, that the Premises have not undergone inspection by a Certified Access Specialist (CASp). As required by Section 1938(e) of the California Civil Code, Lessor hereby states as follows: “A Certified Access Specialist (CASp) can
inspect the subject premises and determine whether the subject premises comply with all of the applicable construction-related accessibility standards under state law. Although state law does not require a CASp inspection of the subject premises,
the commercial property owner or lessor may not prohibit the lessee or Lessee from obtaining a CASp inspection of the subject premises for the occupancy or potential occupancy of 

  

					
		 	 -2-
	 	

 the lessee or Lessee, if requested by the lessee or Lessee. The parties shall mutually agree
on the arrangements for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs necessary to correct violations of construction-related accessibility standards within the
premises.” In furtherance of the foregoing, Lessor and Lessee hereby agree as follows: (a) any CASp inspection requested by Lessee shall be conducted, at Lessee’s sole cost and expense, by a CASp approved in advance by Lessor; and
(b) subject to Section 1 of the Work Letter, Lessee, at its cost, shall be responsible for making any repairs within the Premises to correct violations of construction-related accessibility standards as disclosed by the CASp inspection;
and, if anything done by or for Lessee in its use or occupancy of the Premises shall require repairs to the Building (outside the Premises) to correct violations of construction-related accessibility standards as disclosed by the CASp inspection,
then Lessee shall, at Lessor’s option, either perform such repairs at Lessee’s sole cost and expense or reimburse Lessor upon demand, for the cost to Lessor of performing such repairs. 

6.             Rent. 

6.1.     Base Rent. Prior to the Second Extended Term, Lessee shall continue to pay Base
Rent for the Premises in accordance with the terms of the Lease. Commencing on February 1, 2017, and continuing throughout the Second Extended Term, Lessee shall pay to Lessor monthly installments of Base Rent for the Premises as follows. 

 

																
	 Period During Second

    Extended Term
	  	Annual Base Rent	  	Monthly Installment
of Base Rent	  	Monthly Base Rent
per Rentable
Square Foot
				
	 February 1, 2017 – January 31, 2018
	  	 	$	379,724.40		  	 	$	31,643.70		  	 	$	3.30	
				
	 February 1, 2018 – January 31, 2019
	  	 	$	391,116.12		  	 	$	32,593.01		  	 	$	3.40	
				
	 February 1, 2019 – January 31, 2020
	  	 	$	402,849.60		  	 	$	33,570.80		  	 	$	3.50	
				
	 February 1, 2020 – January 31, 2021
	  	 	$	414,935.04		  	 	$	34,577.92		  	 	$	3.61	
				
	 February 1, 2021 – January 31, 2022
	  	 	$	427,383.12		  	 	$	35,615.26		  	 	$	3.71	
				
	 February 1, 2022 – March 31, 2022
	  	 	$	440,204.64		  	 	$	36,683.72		  	 	$	3.83	

 6.2.     Additional Rent. During the Second Extended
Term, Lessee shall continue to pay Lessee’s Share of Operating Expenses and all other amounts associated with Lessee’s use of the Premises in accordance with the terms of the Lease. 

  

					
		 	 -3-
	 	

 6.3.         Base Rent
Abatement. Provided that Lessee is not then in default of the Lease (as hereby amended), then during the twelfth (12th) month of the Second Extended Term (the “Rent Abatement
Period”), Lessee shall not be obligated to pay any Base Rent otherwise attributable to the Premises during such Rent Abatement Period (the “Base Rent Abatement”). Lessor and Lessee acknowledge that the amount of the Base
Rent Abatement equals $31,643.70. Lessee acknowledges and agrees that the foregoing Base Rent Abatement has been granted to Lessee as additional consideration for entering into this Second Amendment, and for agreeing to pay the Rent and performing
the terms and conditions otherwise required under the Lease (as hereby amended). If Lessee shall be in default under the Lease (as hereby amended) at any time prior to the expiration of the Rent Abatement Period and shall fail to cure such default
within the notice and cure period, if any, permitted for cure pursuant to the Lease (as hereby amended), or if the Lease (as hereby amended) is terminated for any reason, other than as the result of a Lessor default or an event casualty or
condemnation, then, in addition to any other remedies Lessor may have under the Lease (as hereby amended), the dollar amount of the unapplied portion of the Base Rent Abatement as of the date of such default or termination shall be converted to a
credit to be applied to the Base Rent applicable at the end of the Second Extended Term and Lessee shall be required to pay Base Rent for the Premises in full during the Rent Abatement Period. 

6.4.         Additional Base Rent Abatement. In the event that Lessee
notifies Lessor that Lessee has received at least Five Million and No/100 Dollars ($5,000,000.00) in additional equity capital at any time after the mutual execution of this Second Amendment, and such notification includes proof of such additional
funding reasonably acceptable to Lessor (e.g., bank and/or investment account statements; provided that such accounts shall not include any cash deposits held by Lessee which are a subterfuge by Lessee in order to satisfy this condition), then
Lessee shall not be obligated to pay any Base Rent otherwise attributable to the Premises during a one (1) month period (the “Additional Rent Abatement Period”) selected by Lessor within the twelve (12) month period
following the delivery of evidence of such funding commitments to Lessor (the “Additional Base Rent Abatement”). If Base Rent is to be abated pursuant to the terms of this Section 6.4 and prior to the expiration of the
Additional Rent Abatement Period Lessee shall be in default under the Lease (as hereby amended), and shall fail to cure such default within the notice and cure period, if any, permitted for cure pursuant to the Lease (as hereby amended), or if the
Lease (as hereby amended) is terminated for any reason, other than as the result of a Lessor default or an event casualty or condemnation, then, in addition to any other remedies Lessor may have under the Lease (as hereby amended), the dollar amount
of the unapplied portion of the Additional Base Rent Abatement as of the date of such default or termination shall be converted to a credit to be applied to the Base Rent applicable at the end of the Second Extended Term and Lessee shall be required
to pay Base Rent for the Premises in full during the Additional Rent Abatement Period. 

7.         Broker. Lessor and Lessee hereby warrant to each other that
they have had no dealings with any real estate broker or agent in connection with the negotiation of this Second Amendment other than CBRE, Inc., representing Lessor, and Hughes Marino, representing Lessee (collectively, the
“Brokers”), and that they know of no other real estate broker or agent who is entitled to a commission in connection with this Second Amendment. Each party agrees to indemnify and defend the other party against and hold the other
party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments, and costs and expenses (including, 

  

					
		 	 -4-
	 	

 without limitation, reasonable attorneys’ fees) with respect to any leasing commission
or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any real estate broker or agent, other than the Brokers, occurring by, through, or under the indemnifying party. The terms of this section shall
survive the expiration or earlier termination of this Second Amendment. 

8.        Security Deposit. Notwithstanding anything in
the Lease to the contrary, the Security Deposit held by Lessor pursuant to the Lease, as amended hereby, shall equal Fifty Thousand and No/100 Dollars ($50,000.00) (the “Increased Security Deposit”).
Lessor and Lessee acknowledge that, in accordance with Paragraph 5 of the Original Lease, Original Lessee has previously delivered the sum of Forty Thousand and No/100 Dollars ($40,000.00) (the “Existing Security
Deposit”) to Lessor as security for the faithful performance by Original Lessee of the terms, covenants and conditions of the Lease. Concurrently with Lessee’s execution of this Second Amendment, Lessee shall deposit with Lessor
an amount equal to Ten Thousand and No/100 Dollars ($10,000.00) to be held by Lessor as a part of the Increased Security Deposit. To the extent that the total amount held by Lessor at any time as security for the Lease, as hereby amended, is less
than Fifty Thousand and No/100 Dollars ($50,000.00), Lessee shall pay the difference to Lessor within ten (10) days following Lessee’s receipt of notice thereof from Lessor. Lessee hereby waives the provisions of Section 1950.7 of the
California Civil Code and all other provisions of law, now or hereafter in effect, which (i) establish the time frame by which a landlord must refund a security deposit under a lease, and/or (ii) provide that a landlord may claim from a
security deposit only those sums reasonably necessary to remedy defaults in the payment of rent, to repair damage caused by a tenant or to clean the premises, it being agreed that Lessor may, in addition, claim those sums reasonably necessary to
compensate Lessor for any loss or damage caused by Lessee’s default of the Lease, as amended, including, but not limited to, all damages or rent due upon termination of this Lease pursuant to Section 1951.2 of the California Civil Code.

 9.        Management Fee. Paragraph 4.2.4 of
the Addendum is hereby deleted and replaced with “In lieu of including management costs (i.e., fees paid to third-party managers or Lessor’s direct costs for self-managing the Project) in Operating Expenses and paying Lessee’s Share
thereof, commencing on the Commencement Date and continuing through the Term, Lessee shall pay to Lessor monthly on the first day of each calendar month as Additional Rent a separate management fee equal to 3 percent of the then current monthly
Base Rent and Lessee’s Share of Operating Expenses not taking into account any abatement of Base Rent pursuant to Sections 6.3 and 6.4, above.” 

10.        Confidentiality. Lessor and Lessee acknowledge that the
content of the Lease, as amended by this Second Amendment, and any related documents are confidential information. Lessor and Lessee shall keep such confidential information strictly confidential and shall not disclose such confidential information
to any person or entity other than Lessor’s and Lessee’s respective financial, legal, and space planning consultants, and shall not make any public announcement, press release or other public disclosure regarding the Lease, as amended by
this Second Amendment, without the other party’s consent (provided that the foregoing shall not prohibit Lessor from making disclosures to its shareholders, on earnings calls or other reasonably similar disclosures). Notwithstanding the
foregoing, Lessor or Lessee may disclose the terms of this Lease, as amended by this Second Amendment, and any of the other matters described in this Section as follows without violating the confidentiality provision contained in this Section: (i)

  

					
		 	 -5-
	 	

 such disclosures to existing or prospective lenders, purchasers, title companies,
appraisers, and other third persons as may reasonably be necessary in order to conduct its business relating to the Premises and the Building in a commercially reasonable manner; (ii) privileged communications including communications with
counsel, accountants, and advisors; (iii) such disclosures as may be necessary or required by any governmental or regulatory authorities; (iv) such disclosures as may be required by law or by subpoena or any other similar court order or
discovery request in any civil or criminal; (v) such disclosures as may be reasonably required to enforce the terms of this Lease, as amended by this Second Amendment, or any rights and remedies under this Lease, as amended by this Second
Amendment,; and (vi) to the extent that disclosure is mandated by applicable law, the Securities Exchange Commission or the rules of any stock exchange upon which Lessee’s (or Lessee’s parent’s) shares are from time to time
traded. 
 11.        Conflict; No Further
Modification. In the event of any conflict between the Lease and this Second Amendment, the terms of this Second Amendment shall prevail. Except as set forth in this Second Amendment, all of the terms and provisions of
the Lease shall apply with respect to the Premises and shall remain unmodified and in full force and effect. 

  

					
		 	 -6-
	 	

 IN WITNESS WHEREOF, this Second Amendment has been executed as of the day
and year first above written. 
  

					
	 “LESSOR”
	 		 	 “ORIGINAL LESSEE”

			
	 HCP TORREY PINES, LLC,
	 		 	 DERMTECH INTERNATIONAL,

	 a Delaware limited liability company
	 		 	 A California corporation

			
	
By: /s/ Jonathan Bergschneider               
                
	 		 	 By: /s/ S.
Kemper                                        
                                     

	
Name: Jonathan Bergschneider                
                
	 		 	 Name: S.
Kemper                                        
                                     

	
Its: EVP                     
                                         
      
	 		 	 Its:
CFO                                        
                                         
           

			
		 		 	 “LESSEE”

			
		 		 	 DERMTECH, INC.,

		 		 	 a Delaware corporation

			
		 		 	 By: /s/ S.
Kemper                                        
                                    

		 		 	 Name: S.
Kemper                                        
                                    

		 		 	 Its:
CFO                                        
                                         
          

  

					
		 	 -7-
	 	

 EXHIBIT A 

WORK LETTER 

This Work Letter shall set forth the terms and conditions relating to the construction of the improvements in the Premises.
This Work Letter is essentially organized chronologically and addresses the issues of the construction of the Premises, in sequence, as such issues will arise during the actual construction of the Premises. All references in this Work Letter to
Articles or Sections of “the Amendment” shall mean the relevant portion of the Second Amendment to which this Work Letter is attached as Exhibit A and of which this Work Letter forms a part. All references in this Work Letter
to Articles or Sections of “the Lease” shall mean the relevant portion of the Lease. All references in this Work Letter to Articles or Sections of “this Work Letter” shall mean the relevant portion of Articles 1 through
6 of this Work Letter. 
 ARTICLE 1 

IMPROVEMENTS 

Lessor has established or may establish specifications for certain Building standard components to be used in the construction
of the “Improvements” (as that term is defined below) in the Premises. The quality of the Improvements shall be materially consistent with the quality of such Building standards, provided that Lessor may, at Lessor’s option, require
the Improvements to comply with certain Building standards. Lessor may make changes to said specifications for Building standards from time to time, which changes shall only be applicable to the Premises after the completion of the Improvements.

 Using Building standard materials, components and finishes, in a good and workmanlike manner, Lessor shall cause the
installation and/or construction of the improvements in the Premises (the “Improvements”) pursuant to that certain space plan and basis of design attached to this Second Amendment as Exhibit B (the “Space
Plan”). Lessee shall make no changes, additions or modifications to the Improvements or the Space Plan or require the installation of any “Non-Conforming Improvements” (as that term is
defined in Article 2 of this Work Letter), without the prior written consent of Lessor, which consent may be withheld in Lessor’s sole discretion if such change or modification would directly or indirectly delay the substantial
completion of the Improvements or impose any additional costs (unless Lessee agrees to bear such additional costs). Notwithstanding the foregoing or any contrary provision of this Second Amendment, all Improvements shall be deemed Lessor’s
property under the terms of the Lease (as amended) and Lessee shall neither be required to remove the Improvements nor any other Alterations or Utility Installations that are currently within the Premises at the expiration or earlier termination of
the Lease. In addition, to the extent that any code compliance upgrades are required in the Premises or Common Areas in order to allow Lessee to obtain a certificate of occupancy, or its legal equivalent, for the Premises for research and
development and related laboratory, office, and administrative uses assuming normal and customary office occupancy density, Lessor, at Lessor’s sole cost and expense (i.e., not to be included in Operating Expenses) shall cause the Common Areas
and the Premises to comply with applicable building codes and other governmental laws and ordinances, and regulations related to handicap access, which were enacted and enforced as of the date of this Second Amendment. 

  

					
		 	 EXHIBIT A

-1-
	 	

 ARTICLE 2 

OTHER IMPROVEMENTS; IMPROVEMENTS CHANGE 

As more particularly set forth in Article 1 above and subject to all of the other terms and conditions of this Work
Letter, Lessor shall, at Lessor’s sole cost and expense, be responsible for the construction of the Building standard Improvements identified on the Space Plan. Notwithstanding anything to the contrary contained herein including, without
limitation, the items identified in the Final Working Drawings (as that term is defined in Section 3.3, below), Lessee shall be responsible for the cost of all items not identified on the Space Plan and/or any items requiring other than
Building standard materials, components or finishes (collectively, the “Non-Conforming Improvements”). In the event Lessee desires such Non-Conforming
Improvements, Lessee shall deliver written notice (the “Change Notice”) of the same to Lessor, setting forth in detail the Non-Conforming Improvements (the “Improvements
Change”). Lessor shall, within five (5) business days following receipt of a Change Notice related to an Improvements Change, either (i) approve the Improvements Change, or (ii) disapprove the Improvements Change. In the
event that Improvements Change is approved, and incorporated in the Final Working Drawings or the Improvements, any additional costs which arise in connection with such Improvements Change shall be paid by Lessee to Lessor, in advance, upon
Lessor’s request (including but not limited to all costs incurred by Lessor in connection with its review of the Change Notice and any related documents) (all such costs shall collectively be referred to as the “Change
Amount”). Any such amounts required to be paid by Lessee shall be disbursed by Lessor prior to any Lessor provided funds for the costs of construction of the Improvements. In the event Lessee fails to pay the Change Amount, then Lessor may,
at its option, cease work in the Premises until such time as Lessor receives payment of such portion of the Change Amount. 
 ARTICLE 3

 CONSTRUCTION DRAWINGS 

3.1         Selection of Architect/Construction Drawings. To the extent deemed
reasonably necessary by Lessor, Lessor shall retain the architect/space planner designated by Lessor (the “Architect”) to prepare the “Construction Drawings,” as that term is defined in this Section 3.1. To the
extent deemed reasonably necessary by Lessor, Lessor shall retain the engineering consultants designated by Lessor (the “Engineers”) to prepare all plans and engineering working drawings relating to the structural, mechanical,
electrical, plumbing, HVAC, lifesafety, and sprinkler work of the Improvements. The plans and drawings to be prepared by Architect and the Engineers hereunder shall be known collectively as the “Construction Drawings.”
Lessor’s review of the Construction Drawings as set forth in this Section 3, shall be for its sole purpose and shall not imply Lessor’s review of the same, or obligate Lessor to review the same, for quality, design, Code
compliance or other like matters. 
 3.2         Intentionally Omitted. 

3.3        Final Working Drawings. Within five (5) days following the full
execution and delivery of this Lease by Lessor and Lessee, Lessee shall cooperate and coordinate with the Architect and the Engineers in order to allow the Architect and Engineers to complete the 

  

					
		 	 EXHIBIT A

-2-
	 	

 architectural and engineering drawings for the Premises based on the Space Plan, and which
drawings shall be consistent with, and a logical extension of, the Space Plan. The final architectural working drawings shall be in a form to allow subcontractors to bid on the work and to obtain all applicable permits (collectively, the
“Final Working Drawings”). 
 3.4        Permits. The Final
Working Drawings shall be approved by Lessor (the “Approved Working Drawings”) within five (5) business days of receipt and prior to the commencement of the construction of the Improvements. Lessor shall submit the Approved
Working Drawings to the appropriate municipal authorities for all applicable building and other permits necessary to allow “Contractor,” as that term is defined in Section 4.1, below, to commence and fully complete the
construction of the Improvements (the “Permits”). No changes, modifications or alterations in the Approved Working Drawings may be made without the prior written consent of Lessor, provided that Lessor may withhold its
consent, in its sole discretion, to any change in the Approved Working Drawings if such change would directly or indirectly delay the substantial completion of the Premises, or otherwise materially increase the costs of the Improvements (unless
Lessee agrees to bear such increased cost). Any such foregoing cost increases shall also be deemed a component of the Change Amount. 

3.5        Electronic Approvals. Notwithstanding any provision to the contrary
contained in the Lease (as amended) or this Work Letter, Lessor may, in Lessor’s sole and absolute discretion, transmit or otherwise deliver any of the approvals required under this Work Letter via electronic mail to Lessee’s
representative identified in Section 6.2 of this Work Letter, or by any of the other means identified in Paragraph 23 of the Addendum. 

ARTICLE 4 

LESSEE’S AGENTS 

4.1         Contractor. A contractor designated by Lessor
(“Contractor”) shall construct the Improvements. 
 4.2
        Intentionally Omitted. 
 4.3
        Construction of Improvements by Contractor under the Supervision of Lessor. 

4.3.1         Change Amount. Within ten (10) days following a demand therefor
from Lessor, Lessee shall deliver to Lessor the amount of the Change Amount. The Change Amount shall be disbursed by Lessor towards the costs of the Improvements, as reasonably determined by Lessor. In the event that any revisions, changes, or
substitutions shall be made to the Construction Drawings or the Improvements at Lessee’s request, any additional costs which arise in connection with such revisions, changes or substitutions or any other additional costs shall be paid by Lessee
to Lessor immediately upon Lessor’s request as an addition to the Change Amount. In addition, if any Non-Conforming Improvements shall require alterations in the Base Building (as contrasted with the Improvements), and if Lessor in its sole and
exclusive discretion agrees to any such alterations, and notifies Lessee of the need and cost for such alterations, then Lessee shall pay the cost of such required changes in advance upon receipt of notice thereof. Lessee shall pay all direct
architectural and/or engineering fees in connection therewith, plus five percent (5%) of such direct 

  

					
		 	 EXHIBIT A

-3-
	 	

 costs for Lessor’s servicing and overhead. In the event that Lessee fails to deliver
the Change Amount as provided in this Section 4.3.1, then Lessor may, at its option, cease work in the Premises until such time as Lessor receives payment of the Change Amount. 

4.3.2        Lessor’s Retention of Contractor. Lessor shall independently
retain Contractor to construct the Improvements in accordance with the Approved Working Drawings and Lessor shall supervise the construction by Contractor. 

4.3.3        Contractor’s Warranties and Guaranties. Lessor hereby
assigns to Lessee all warranties and guaranties by the Contractor relating to the Improvements, and Lessee hereby waives all claims against Lessor relating to or arising out of the design and construction of the Improvements and/or Non-Conforming Improvements. 

4.4        Lessee’s Agents. Lessee hereby protects, defends, indemnifies
and holds Lessor harmless for any loss, claims, damages or delays arising from the actions of Lessee’s space planner/architect and/or any separate contractors, subcontractors or consultants on the Premises or in the Building. 

ARTICLE 5 

LESSEE’S OCCUPANCY OF PREMISES DURING CONSTRUCTION 

Lessee hereby acknowledges that, notwithstanding Lessee’s occupancy of the Premises during the construction of the Improvements by
Lessor, Lessor shall be permitted to construct the Improvements during normal business hours, without any obligation to pay overtime or other premiums. To the extent that, in Lessor’s reasonable opinion, the construction of the Improvements
require the temporary relocation or other movement of furniture, fixtures or equipment located in the Premises (the “FF&E”), Lessee shall, upon request by Lessor, temporarily relocate and/or move such FF&E at Lessee’s
sole cost and expense. Lessee hereby agrees that the construction of the Improvements shall in no way constitute a constructive eviction of Lessee nor entitle Lessee to any abatement of rent payable pursuant to the Lease. Lessor shall have no
responsibility or for any reason be liable to Lessee for any direct or indirect injury to or interference with Lessee’s business arising from the construction of the Improvements, nor shall Lessee be entitled to any compensation or damages from
Lessor for loss of the use of the whole or any part of the Premises or of Lessee’s personal property or improvements resulting from the construction of the Improvements or Lessor’s actions in connection with the construction of the
Improvements, or for any inconvenience or annoyance occasioned by the construction of the Improvements or Lessor’s actions in connection with the construction of the Improvements; provided however, Lessor hereby agrees to use commercially
reasonable efforts to minimize the disruption caused to Lessee by the construction of the Improvements. 
 ARTICLE 6 

MISCELLANEOUS 

6.1        Intentionally Omitted. 

  

					
		 	 EXHIBIT A

-4-
	 	

 6.2        Lessee’s
Representative. Lessee has designated Steve Kemper as its sole representative with respect to the matters set forth in this Work Letter (whose e-mail address for the purposes of this Work Letter is
skemper@dermtech.com), who, until further notice to Lessor, shall have full authority and responsibility to act on behalf of the Lessee as required in this Work Letter. 

6.3        Lessor’s Representative. Lessor has designated Jeffrey P.
Sobczyk as “Project Manager” (whose e-mail address for the purposes of this Work Letter is [●], who shall be responsible for the implementation of all Improvements to be performed by
Lessor in the Premises. With regard to all matters involving such Improvements, Lessee shall communicate with the Project Manager rather than with the Contractor. Lessor shall not be responsible for any statement, representation or agreement made
between Lessee and the Contractor or any subcontractor. It is hereby expressly acknowledged by Lessee that such Contractor is not Lessor’s agent and has no authority whatsoever to enter into agreements on Lessor’s behalf or otherwise bind
Lessor. The Project Manager will furnish Lessee with notices of substantial completion, cost estimates for above standard Improvements, Lessor’s approvals or disapprovals of all documents to be prepared pursuant to this Work Letter and changes
thereto. 
 6.4        Lessee’s Agents. To the extent necessary to
maintain labor harmony, all subcontractors, laborers, materialmen, and suppliers retained directly by Lessee shall all be union labor in compliance with the master labor agreements existing between trade unions and the Southern California Chapter of
the Associated General Contractors of America. 
 6.5        Time of the Essence
in this Work Letter. Unless otherwise indicated, all references herein to a “number of days” shall mean and refer to calendar days. In all instances where Lessee or Lessor is required to approve or deliver an item, if no written notice
of approval is given or the item is not delivered within the stated time period, at Lessor’s or Lessee’s sole option (as the case may be), at the end of such period the item shall automatically be deemed approved or delivered by Lessee or
Lessor (as the case may be) and the next succeeding time period shall commence. 

6.6        Lessee’s Lease Default. Notwithstanding any provision to the
contrary contained in the Lease (as amended) or this Work Letter, if any default by Lessee under the Lease (as amended) or this Work Letter (including, without limitation, any failure by Lessee to fund in advance the costs for any Non-Conforming
Improvements) occurs, then (i) in addition to all other rights and remedies granted to Lessor pursuant to the Lease (as amended), Lessor shall have the right to cause the cessation of construction of the Improvements (in which case, Lessee
shall be responsible for any delay in the substantial completion of the Improvements and any costs occasioned thereby), and (ii) all other obligations of Lessor under the terms of the Lease (as amended) and this Work Letter shall be forgiven until
such time as such default is cured pursuant to the terms of this Lease. 

  

					
		 	 EXHIBIT A

-5-
	 	

 Exhibit B 

Space Plan 
  

 

  

					
		 	 Exhibit B

-1-
	 	

 

 

  

					
		 	 Exhibit B

-2-
	 	

 BASIS OF DESIGN 

11099 N. Torrey Pines Road, First Floor – Dermtech 

Expansion of Break Room and Remodel of Lab and Office Areas 

11/14/2016 
 Based on floor plan by
McFarlane Architects dated 11/9/16. 

	A.	 Existing Conference Room 

 

	 	1.	 Demo and remove built in credenza/millwork 

 

	 	2.	 Patch and repair drywall at former millwork area, prime and paint 

 

	 	3.	 Rubber base, carpet tiles to match existing (alternate to replace carpet tiles throughout new office area)

  

	 	4.	 All furniture, fixtures and equipment to be provided and installed by Tenant. 

 

	B.	 Existing Office Area 

 

	 	1.	 Re-frame office opening, relocate door, repair replace ceiling grid as necessary and provide replacement
tiles by Armstrong or equivalent for any ceiling tiles damaged during construction. New grid height wall to accommodate expanded break room and new dimension of office, rubber base, carpet tiles to match existing (add alternate to replace carpet
tiles throughout new office area), existing light fixtures to be re-switched and relocated as necessary. 

  

	 	2.	 All furniture, fixtures and equipment to be provided and installed by Tenant. 

 

	C.	 New Break Room 

  

	 	1.	 Remove existing flooring, sink and millwork and relocate plumbing per plan. 

 

	 	2.	 Install VCT tile flooring and rubber base (Armstrong or equivalent), plastic laminate upper and lower
cabinets with solid surface countertops, stainless steel double-basin sink with single faucet, space in millwork to accommodate refrigerator and dishwasher including plumbing. 

 

	 	3.	 Removal of existing storefront windows at new breakroom location and installation of new sliding/stacking
door system at location more specifically defined on approved floor plans. Patch and repair patio tile as required; match existing. 

  

	 	4.	 Frame, drywall, prime and paint over any exposed exterior finishes within footprint of new breakroom area
only. New interior ceiling area will receive ceiling grid and tile to match existing. Relocate sprinkler drops as needed. 

  

	 	5.	 Refrigerator provided by Tenant, dishwasher provided by Tenant. Both installed by Landlord as part of the
Landlord scope. 

  

	D.	 Patio Door 

  

	 	1.	 Cut in and supply new exterior storefront door assembly at location noted on approved plans.

  

	 	2.	 Patch and repair patio tile as required; match existing 

 

	E.	 Existing restrooms and adjacent hallway 

 

	 	1.	 Re-frame new restroom opening, relocate door, repair, patch, prime
and paint drywall at affected areas. Reframe and refinish ceiling as required at new restroom door area. Relocate sprinkler drops as needed. 

  

	 	2.	 Relocate existing restroom signage and fixtures as required to accommodate new door location.

  

					
		 	 Exhibit B

-3-
	 	

	F.    	 Laboratory 

  

	 	1.	 Relocate emergency shower (location within lab TBD by Tenant) and repair ceiling tile at affected area with
matching office spec. 

  

	 	2.	 Relocate existing Tenant refrigerators within existing Dermtech space (location TBD) and relocate existing
emergency power accordingly (location TBD by Tenant). 

  

	 	3.	 Demolish existing north wall and install new grid-height finished wall at location noted on approved floor
plans. 

  

	 	4.	 Supply new door, frame and hardware at location noted on approved plans. Match existing office spec.

  

	 	5.	 At locations of demolition patch and repair existing VCT, ceiling grid and tiles with matching or
complimentary spec (Armstrong or equivalent). Match existing office spec. 

  

	 	6.	 Relocate existing lab casework according to approved floor plan, replacing existing countertops with new
(Chemsurf laminate or equivalent). 

  

	 	7.	 Install convenience power at former lab refrigerator location; coordinate outlet locations with relocated
lab casework and Tenant. 

 MEP GUIDELINES: 
  

	 	·	 	 Must adhere to base building Standards and Basis of Design. Tenant select from Landlord’s base Standards and
colors. 

 EXCLUSIONS: 
  

	 	·	 	 New Title 24 Fixtures or Controls (unless code required). If code required at Landlord’s sole cost.

	 	·	 	 AV/IT racks and cabling 

	 	·	 	 TVs, projectors/projection screens 

	 	·	 	 Window coverings unless otherwise noted 

	 	·	 	 Furniture, including file cabinets 

	 	·	 	 Security System 

	 	·	 	 Communication System 

	 	·	 	 UPS System 

	 	·	 	 DAS System 

	 	·	 	 Tenant FF&E 

	 	·	 	 Ceiling service panels and specialty gas outlets/piping/gas manifolds unless otherwise noted

	 	·	 	 Nitrogen sources and piping 

	 	¡ 	 	 Ice Makers 

	 	¡ 	 	 Incubators 

	 	·	 	 Signage, other than code required 

  

					
		 	 Exhibit B

-4-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00299-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00299-of-00352.parquet"}]]