Document:

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                                                                   EXHIBIT 10.12

                AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT

     THIS AGREEMENT (the "Restated Agreement"), effective as of the 1st day of
April, 1993, (the "Effective Date") by and between the CORNELL RESEARCH
FOUNDATION, INC., having offices at Cornell Business & Technology Park, 20
Thornwood Drive, Suite 105, Ithaca, New York 14850 (hereinafter referred to as
"FOUNDATION") and GENVEC, INC., having offices at 12111 Parklawn Drive,
Rockville, Maryland 20852 (hereinafter referred to as "LICENSEE").

                         W I T N E S S E T H  T H A T:

     WHEREAS, FOUNDATION is a wholly owned subsidiary corporation of Cornell
University and holds the ownership interests of patents issued on inventions
made by Cornell University's staff and administers licenses in a manner
consistent with the patent policy of Cornell University;

     WHEREAS, FOUNDATION represents that it is assignee of the patents and/or
patent applications included within the Sponsored Research Intellectual Property
(as defined below) and any patents issuing thereon and has the right to grant
licenses under said patents and/or patent applications and patents issuing
thereon;

     WHEREAS, LICENSEE and FOUNDATION previously entered into that certain
Sponsored Research Agreement effective as of May 18, 1993 (the "Prior Crystal
Sponsored Research Agreement"), pursuant to which LICENSEE agreed to fund
certain research conducted under the supervision of Dr. Crystal at the Cornell
University Medical College ("CUMC").

     WHEREAS, LICENSEE and FOUNDATION previously entered into that certain
Sponsored Research Agreement effective as of July 10, 1995 (the "Prior Falck-
Pedersen Sponsored Research Agreement"), pursuant to which LICENSEE agreed to
fund certain research conducted under the supervision of Dr. Falck-Pedersen at
the Cornell University Medical College.

     WHEREAS, LICENSEE and FOUNDATION intend to supersede the Prior Crystal
Sponsored Research Agreement with a further Sponsored Research Agreement
pursuant to which LICENSEE expects to fund certain research conducted under the
supervision of Dr. Crystal at the Cornell University Medical College, and
LICENSEE and FOUNDATION may enter into other agreements pursuant to which
LICENSEE may support the conduct of research at Cornell University Medical
College and its affiliated clinical entities.

     WHEREAS, FOUNDATION has previously granted to LICENSEE an exclusive license
under (i) FOUNDATION's rights included in the Sponsored Research Intellectual
Property (as defined in the Prior Crystal Sponsored Research Agreement)
including the Designated Inventions,

[*]=CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO
THE OMITTED PORTIONS.

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Biological Material and Technical Information and related intellectual property
rights subject to that certain License Agreement entered April 1, 1993, and (ii)
under FOUNDATION's rights in the Subject Inventions (as defined in the Prior
Falck-Pedersen Sponsored Research Agreement) including the Designated
Inventions, Biological Material and Technical Information and related
intellectual property rights subject to that certain License Agreement entered
July 10, 1995;

     WHEREAS, FOUNDATION and LICENSEE wish to amend and restate the License
Agreements and to include under this Restated Agreement exclusive, worldwide
licenses under the discoveries and inventions embodied in the Sponsored Research
Intellectual Property Rights (as defined below);

     WHEREAS, as a benefit of funding such research, FOUNDATION is willing to
grant to LICENSEE an exclusive license under FOUNDATION's rights in such
Sponsored Research Intellectual Property Rights upon the terms and conditions
hereinafter set forth;

     WHEREAS, the work leading to the Sponsored Research Intellectual Property
was supported in part by an agency of the U.S. Government, FOUNDATION is
obligated to comply with the U.S. Office of Management & Budgets Circular No. A-
124, or 37 CFR Part 401; and

     WHEREAS, such FOUNDATION and LICENSEE have entered into a Warrant Agreement
on even date herewith, pursuant to which LICENSEE shall provide to FOUNDATION
warrants to purchase shares of GenVec stock, in accordance with the terms and
conditions therein.

     NOW, THEREFORE, in consideration of the covenants and obligations
hereinafter set forth, the parties hereto hereby agree as follows:

                                        I

                                   DEFINITIONS

     The following definitions will apply throughout this Restated Agreement:

     1.1  "AFFILIATE" shall mean any corporation or other entity which is
directly or indirectly controlling, controlled by or under the common control of
a party hereto. For the purpose of this Restated Agreement, "control" shall mean
the direct or indirect ownership of at least fifty percent (50%) of the
outstanding shares or other voting rights of the subject entity to elect
directors, or if not meeting the preceding, any entity owned or controlled by or
owning or controlling at the maximum control or ownership rights permitted in
the country where such entity exists.

     1.2  "BIOLOGICAL RESEARCH MATERIALS" shall mean any protein, gene, gene
vector, plasmid or other construct, cell line, hybridoma, antibody or other
biological material or derivative or analogs thereof, created by one or more
employees of Cornell University and arising out of the Sponsored Research
conducted pursuant to any of the Sponsored Research Agreements (except to the
extent such biological material is subject to the Material Transfer Agreement).
It is understood and agreed

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that the Biological Research Materials shall include, without limitation, the
Biological Materials (as defined in the Prior Sponsored Research Agreements
and/or License Agreements).

     1.3  "CONFIDENTIAL INFORMATION" shall mean (i) any proprietary or
confidential information or material in tangible form disclosed hereunder that
is marked as "Confidential" at the time it is delivered to the receiving party,
or (ii) proprietary or confidential information disclosed orally hereunder which
is identified as confidential or proprietary when disclosed and such disclosure
of confidential information is confirmed in writing within thirty (30) days by
the disclosing party.

     1.4  "LICENSEE" shall mean GenVec, Inc. and its Affiliates.

     1.5  "LICENSE YEAR" shall mean each twelve (12) month period beginning on
the effective date of this Restated Agreement first written above and thereafter
on the anniversary date thereof.

     1.6  "LICENSED APPLICATION" shall mean any U.S. patent application within
the Sponsored Research Intellectual Property Rights and any continuation,
continuation-in-part, or divisional applications thereof, as well as foreign
counterparts thereof.

     1.7  "LICENSED PATENT" shall mean any U.S. Patent issuing from a Licensed
Application, and all extensions, reissues and re-examinations thereof, as well
as foreign counterparts thereof.

     1.8  "LICENSED PRODUCT" shall mean any product, composition or material,
within the scope of a Valid Claim, or which incorporates, in material part,
Biological Research Materials.

     1.9  "MATERIAL TRANSFER AGREEMENT" shall mean that certain Material
Transfer Agreement entered by LICENSEE and Cornell University Medical College
effective as of December 19, 1996.

     1.10 "NET SALES PRICE" shall mean the gross amount received by LICENSEE or
its sublicensees in arm's length sales to third parties of Licensed Products,
after deduction of the following items to the extent such items are incurred and
do not exceed reasonable and customary amounts for each such item in the market
in which such sale occurred:

          1.10.1 trade, cash and quantity discounts or rebates, actually allowed
or taken;

          1.10.2 credits or allowances given or made for rejection or return of,
and for uncollectible amounts on, previously sold Licensed Products or for
retroactive price reductions;

          1.10.3 any separately invoiced tax, duty or other government charge
(other than an income tax) levied on the sale, transportation or delivery of a
Licensed Product and borne by the seller thereof; and

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          1.10.4 any separately invoiced charges for freight, packaging and
insurance.

Net Sales Price shall not include sales or transfers between LICENSEE and its
subsidiaries, Affiliates or sublicensees, except that where such subsidiary,
Affiliate or sublicensee utilizes the Licensed Products for the performance of
commercial services for third party customers, Net Sales Price shall be based on
subsequent final sales of such Licensed Products to third parties by such
Affiliates or sublicensees, unless the intermediate sales price to a sublicensee
is higher than the subsequent final Sales Price, in which case the intermediate
Sales Price shall control.

     1.11 "SPONSORED RESEARCH AGREEMENTS" shall mean the Prior Sponsored
Research Agreements and the Other Sponsored Research Agreements.

          1.11.1 "PRIOR SPONSORED RESEARCH AGREEMENTS" shall mean each of the
Prior Crystal Sponsored Research Agreement and the Prior Falck-Pedersen
Sponsored Research Agreement.

          1.11.2 "OTHER SPONSORED RESEARCH AGREEMENTS" shall mean any Sponsored
Research Agreement entered by LICENSEE and FOUNDATION (or its affiliated
clinical entities) after December 31, 1997.

     1.12 "SPONSORED RESEARCH INTELLECTUAL PROPERTY RIGHTS" shall mean
individually and collectively, all patent applications, patents, and patentable
discoveries and inventions arising, in whole or in part, out of the Sponsored
Research conducted pursuant to any of the Sponsored Research Agreements that are
first conceived or discovered and/or reduced to practice (i) by one or more
employees of the University, or (ii) jointly by one or more employees of the
University and by one or more employees of the Sponsor, or (iii) by one or more
inventors not employed in Dr. Crystal's laboratory (if funds from Sponsor
Payments have been directly utilized to make such invention), and all Biological
Research Materials and Technical Information. The parties expect that due to the
level of Sponsor Payments provided by the Sponsor will include, but not be
limited to, all Gene Therapy inventions first conceived or discovered and/or
reduced to practice in Dr. Crystal's laboratory will fall with the definition of
"Sponsored Research Intellectual Property Rights." For the avoidance of doubt,
it is understood and agreed that the Sponsored Research Intellectual Property
Rights shall include, without limitation, the Sponsored Research Intellectual
Property (as defined in the Prior Crystal Sponsored Research Agreement) and
Subject Inventions (as defined in the Prior Falck-Pedersen Sponsored Research
Agreement). Neither this definition, nor any other provision of this Restated
License Agreement or any Sponsored Research Agreement, shall give the Sponsor
any rights in any patent application, patent, patentable discovery or invention
first conceived or discovered and/or reduced to practice except as described
above, or directly or indirectly related to or arising out of Dr. Crystal's
duties and responsibilities for Medical College programs outside Dr. Crystal's
laboratory including the CUMC gene therapy core (provided no Sponsor Payments
are used in connection with such activities); provided, however, that the
foregoing shall not affect the Sponsor's right to have an opportunity to
negotiate with a third-party joint inventor without prior obligations to
Sponsor.

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     1.13 "TECHNICAL INFORMATION" shall mean and include all technical
information, developments, discoveries and know-how, methods, techniques,
formulae, processes, and other information conceived and/or discovered and/or
reduced to practice in connection with research conducted pursuant to any of the
Sponsored Research Agreements. "Technical Information" shall exclude any of the
foregoing that are included within a claim of a Licensed Patent or a Licensed
Application or which are Biological Research Materials.

     1.14 "VALID CLAIM" shall mean a claim of an issued and unexpired patent or
a claim of a pending patent application which has not been held unpatentable,
invalid or unenforceable by a court or other government agency of competent
jurisdiction and has not been admitted to be invalid or unenforceable through
reissue, re-examination, disclaimer or otherwise; provided, however, that if any
holding of invalidity, unenforceability or unpatentability is later reversed by
a court or agency with overriding authority, the relevant claim shall be
reinstated as a Valid Claim hereunder with respect to sales made after the date
of such reversal. Notwithstanding the foregoing provisions of this Section 1.14,
if a claim of a pending patent application has not issued as a claim of an
issued patent, within * after the date from which such claim takes priority,
such pending claim shall not be a Valid Claim for purposes of this Agreement
unless and until a patent issues including such claim.

                                       II

                                      GRANT

     2.1 Subject only to the prevailing rights of and obligations to the U.S.
Government with respect to ownership of intellectual property derived in the
course of federally sponsored research, including, without limitation, any such
rights and obligations set forth in 37 CFR Part 401, should they exist,
FOUNDATION hereby grants to LICENSEE for the term set forth below and under the
royalty basis set forth below, an exclusive license under the Sponsored Research
Intellectual Property Rights (and related Licensed Applications and Licensed
Patents) to make, have made, use, lease, import, have imported, offer for sale,
sell and otherwise exploit Licensed Products in the United States and throughout
the world, with the right to grant sublicenses, as set forth in Article XII
INFRA; or a semi-exclusive license in the case of an invention within the
Sponsored Research Intellectual Property Rights invented jointly with a third
party, since while FOUNDATION is obligated to license "exclusively" to LICENSEE
the rights obtained by FOUNDATION through the inventive activity of Dr. Crystal,
and/or employees of Cornell University in the course of Sponsored Research,
FOUNDATION is not obligated to license to LICENSEE rights obtained by a
third-party inventor, thus creating a semi-exclusive license situation, unless
LICENSEE in a separate agreement acquires the exclusive rights of the third
party inventor, so as to create a bundle of rights which together comprise an
"exclusive license". The term "exclusive license" as used hereinabove shall mean
that FOUNDATION shall not issue a license to another, nor will FOUNDATION make,
use or sell Licensed Products, within the period of exclusivity set forth
hereinafter or any agreed upon extension thereof and FOUNDATION shall not
knowingly take, and shall make reasonable efforts to cause CUMC and all
personnel engaged by the University not to take, any actions inconsistent with
the grant of such an exclusive license;

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     2.2 FOUNDATION shall retain the nontransferable right to practice the
Sponsored Research Intellectual Property Rights for its internal, academic, non-
commercial research.

     2.3 Promptly following execution of this Agreement, FOUNDATION shall
transfer to LICENSEE a sufficient quantity of the Biological Research Materials
existing as of the Effective Date, and thereafter as Biological Research
Materials are developed, in each case, as are reasonable and necessary for
LICENSEE to establish a viable culture of such Biological Research Materials.
LICENSEE shall reimburse FOUNDATION for the reasonable out-of-pocket costs
incurred by FOUNDATION in transferring the Biological Research Materials to
LICENSEE.

                                       III

                                  TO HAVE MADE

     3.1 The right of LICENSEE and its sublicensees to make Licensed Products
includes the right to have made Licensed Products by contract with third
parties. Such contractual arrangements with third parties shall be subject to
and conditioned upon appropriate supervision and quality assurance and control
of the third party by LICENSEE and the third party shall be bound in writing to
respect all rights of FOUNDATION and to supply any production of Licensed
Products made by such third party exclusively to LICENSEE or a sublicensee of
LICENSEE.

                                       IV

                      FOREIGN PATENTS AND PAYMENT OF COSTS

     4.1 As the opportunity to file foreign counterpart applications of Licensed
Applications exists, LICENSEE may designate foreign countries where counterpart
applications shall be filed and FOUNDATION shall ensure that such patent
applications are timely filed in such designated countries. FOUNDATION will use
counsel reasonably acceptable to LICENSEE in connection with the preparation and
filing of such Licensed Applications. FOUNDATION shall direct such counsel to
provide LICENSEE an opportunity to review and comment on all papers to be filed
with any patent office at least fifteen (15) business days before such filing,
and to include in such paper any arguments and claims as LICENSEE may request,
and to promptly provide to LICENSEE copies of any documents received from any
patent office relating to the Licensed Applications.

     4.2 LICENSEE agrees to pay for all reasonable and customary expenses
incurred in the preparation, filing, prosecution, renewal and continuation of
Licensed Patents and Licensed Applications in said designated countries
including all taxes, official fees and attorney's fees. Notwithstanding the
foregoing, LICENSEE may elect in writing to be released from its license any
such Licensed Patents and/or Licensed Applications at any time, in which event
it shall thereafter have no obligation to reimburse FOUNDATION for any future
expenses relating to such patent or patent application.

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                                        V

                              PAYMENT OF U.S. FEES
                        AND CONTINUING PROSECUTION COSTS

     5.1 Where renewal fees are due on a licensed United States patent within
the Sponsored Research Intellectual Property Rights and LICENSEE remains
exclusively licensed, LICENSEE agrees to reimburse FOUNDATION for the costs of
said renewal within thirty (30) days of notice thereof to LICENSEE by
FOUNDATION.

     5.2 Where Licensed Applications are pending in the United States, LICENSEE
agrees to pay all reasonable prosecution costs for such applications at least
through an appeal to the U.S. Patents & Trademark Office Board of Appeals, if
the parties agree such an appeal is appropriate.

     5.3 LICENSEE agrees to pay for all reasonable and customary expenses
incurred in the preparation, filing, prosecution, renewal and continuation of
Licensed Patents and Licensed Applications in the United States including all
taxes, official fees and attorney's fees. Notwithstanding the foregoing,
LICENSEE may elect in writing to be released from its license any such Licensed
Patents and/or Licensed Applications at any time, in which event it shall
thereafter have no obligation to reimburse FOUNDATION for any future expenses
relating to such patent or patent application.

     5.4 FOUNDATION shall direct counsel prosecuting the Licensed Applications
to provide LICENSEE an opportunity to review and comment on all papers to be
filed with any patent office at least fifteen (15) business days before such
filing, and to include in such papers any arguments and claims as LICENSEE may
request, and to promptly provide to LICENSEE copies of any documents received
from any patent office relating to the Licensed Applications.

                                       VI

                      ROYALTIES AND MINIMUM ROYALTIES TO BE
                        PAID DURING THE LICENSE AGREEMENT

     6.1 Beginning on March 1, 1998, and continuing for a three (3) year period
thereafter, LICENSEE shall pay FOUNDATION a Thirty Thousand Dollar ($30,000.00)
maintenance fee for that License Year, and following such three (3) year period,
LICENSEE shall pay FOUNDATION a Fifty Thousand Dollar ($50,000.00) maintenance
fee for each License Year during the term of this Restated Agreement. Such
monies will be considered as a credit for any royalties due for that License
Year under this Restated Agreement and the royalty reports may reflect the use
of such credit. Such provision is to be construed as an annual maintenance fee
payment requirement and none of the maintenance fee payments are refundable or
applicable to succeeding License Years.

     6.2 LICENSEE will pay to the FOUNDATION a royalty of * of the Net Sales
Price of Licensed Products within the scope of an issued Valid Claim in the
country of manufacture or sale.

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     6.3 If a Licensed Product is covered in the country of manufacture or sale
only by a Valid Claim of a Licensed Patent owned jointly by the FOUNDATION and
LICENSEE, the royalty rate * .

     6.4 If a Licensed Product is covered in the country of manufacture or sale
only by a Valid Claim of a Licensed Application, * of the Net Sales Price.

     6.5 In the event that a Licensed Product is sold in combination as a single
product with another product or component whose sale and use are not covered by
a claim within the Sponsored Research Intellectual Property Rights in the
country for which the combination product is sold, Net Sales Price from such
sales for purposes of calculating the amounts due under this Article VI above
shall be calculated by multiplying the Net Sales Price of that combination by
the fraction A/(A+B), where A is the selling price of the Licensed Product and B
is the selling price of the other product or component sold separately. In the
event that no such separate sales are made, the Net Sales Price for royalty
determination shall be as reasonably allocated by LICENSEE between such Licensed
Product and such other product or component, based upon their relative
importance and proprietary protection.

     6.6 If LICENSEE or its sublicensee is required to pay a third party with
respect to a license for intellectual property rights or other technologies
which LICENSEE, or its sublicensee, in its reasonable judgment, determines are
necessary to practice the Sponsored Research Intellectual Property Rights,
LICENSEE may offset such amounts against royalties due to FOUNDATION for such
Licensed Product. Notwithstanding the foregoing provisions of this Section 6.6
in no event shall the royalties due to FOUNDATION hereunder be reduced * of the
amount that would otherwise be due FOUNDATION pursuant to this Restated
Agreement.

     6.7 If LICENSEE or its sublicensee is required to pay a third party with
respect to a license for intellectual property rights or other technologies
which LICENSEE, or its sublicensee, in its reasonable judgment, determines are
necessary or useful to make, use or sell a Licensed Product, but are not
required to practice the Sponsored Research Intellectual Property Rights,
LICENSEE may offset such amounts owing to such third parties against royalties
due to FOUNDATION for such Licensed Product. Notwithstanding the foregoing
provisions of this Section 6.7 in no event shall the royalties due to FOUNDATION
hereunder be so * of the amount that would otherwise be due FOUNDATION pursuant
to this Restated Agreement.

     6.8 It is understood and agreed that regardless of any credits or offsets
to which LICENSEE or its sublicensees are entitled under the terms of this
Restated Agreement, the royalty payments due FOUNDATION under this Article 6 *
Net Sales Price of any Licensed Product.

     6.9 In the event that more than one Valid Claim within the Licensed Patents
is applicable to any Licensed Product, then only one royalty shall be paid to
FOUNDATION in respect of such Licensed Product. It is understood that royalties
shall only be payable under this Article VI with respect to Licensed Products
whose sale would infringe a Valid Claim in the country for which such Licensed
Product is sold. In no event shall more than one royalty be due hereunder with
respect to

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any Licensed Product unit, nor shall a royalty be payable under this Article VI
with respect to sales of Licensed Products for use in research and/or
development, in clinical trials or as samples.

     6.10 With respect to the possible renegotiation of royalty rates with
regard to any Sponsored Research Intellectual Property Rights subject to this
Agreement, FOUNDATION shall promptly notify LICENSEE if it believes that any
such a renegotiation is required under the Tax Reform Act of 1986 specifically
identifying the applicable intellectual property, and in such event the
following shall apply:

          6.10.1 FAIR CONSIDERATION. FOUNDATION and LICENSEE have determined
that the consideration payable to the FOUNDATION pursuant to this Agreement is
fair and competitive with respect to all reasonably conceivable inventions and
other intellectual property which might be developed by FOUNDATION under any of
the Sponsored Research Agreements at the time each Sponsored Research Agreement
was executed.

          6.10.2 LIMITED RENEGOTIATION EVENTS.  If, notwithstanding the above,
inventions or other discoveries are developed during the term of this Agreement
which were not reasonably conceivable as arising out of or resulting from the
research conducted under the Sponsored Research Agreements (each an "Invention")
and with respect to which the consideration payable to FOUNDATION under this
Agreement is not reasonably believed by FOUNDATION to be competitive, FOUNDATION
shall notify LICENSEE in writing of such determination; provided, however, that
any such renegotiation right of FOUNDATION shall cease and be of no further
force or effect with respect to any Invention from and after 180 days after the
time at which the first Licensed Application on such Invention is filed or other
intellectual property protection is first sought (or, in the case of a
Biological Material, after the time such Biological Material is first indicated
as a possible Invention by LICENSEE). In the event that LICENSEE disputes such
determination of FOUNDATION and the request for renegotiation, LICENSEE shall
have a right, but not the obligation, to submit the issue to arbitration
pursuant to Article XIV hereunder. The arbitration result shall be final and
binding. The arbitrator or Panel shall determine whether (i) it was reasonably
conceivable as of the date the applicable Sponsored Research Agreement was
entered that the subject Invention might have been made or otherwise developed
in connection with the Sponsored Research Agreement and, if not, (ii) whether
the compensation payable under the Agreement is reasonably competitive with
regard to such Invention, based on all relevant circumstances, including without
limitation, the Warrant Agreement provided in partial consideration for the
grant of rights in this Agreement (the "Issues"). The expenses of the
arbitration shall be borne by LICENSEE, except that the Arbitrator may assign
the expenses to FOUNDATION if, in the Arbitrator's opinion, the decision by
FOUNDATION to request arbitration was clearly unreasonable. If either of the
Issues is resolved in favor of LICENSEE, there shall be no renegotiation of
consideration payable with respect to the Inventions or Licensed Products. If
both Issues are resolved in favor of FOUNDATION, the parties shall proceed as
set forth in subparagraph (iii) hereunder.

          6.10.3 RENEGOTIATION PROCESS. If either LICENSEE agrees to renegotiate
the consideration payable without arbitration or if the Arbitrator determines
the Issues in favor of

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FOUNDATION, LICENSEE shall have an exclusive right for 90 days to negotiate with
FOUNDATION a royalty arrangement reasonably acceptable to FOUNDATION, which
shall use reasonable efforts to reach satisfactory agreement with LICENSEE.

          6.10.4 Right of First Refusal.  In the event that FOUNDATION and
LICENSEE are unable to reach agreement within such 90 day period, FOUNDATION
shall then have the right to negotiate with third parties other than LICENSEE
with respect to the exclusive licensing of the particular Invention in question;
provided, however, that if FOUNDATION proposes to enter into any agreement for
the licensing of such Invention to any third party, FOUNDATION shall notify
LICENSEE in writing of the proposed terms and LICENSEE shall have a right of
first refusal exercisable within 30 days of receipt of such notice to enter into
an exclusive license with FOUNDATION on substantially similar terms.

     6.11 Royalties due under this Article VI shall be payable on a country-by-
country and Licensed Product-by Licensed Product basis until the expiration of
the last-to-expire issued Valid Claim covering such Licensed Product in such
country. It is understood that LICENSEE'S obligation to pay royalties with
respect to a particular Licensed Product shall cease:

          (i) if the applicable claims in the Licensed Patent in any particular
country are held invalid by an unappealed or unappealable decision of a court of
competent jurisdiction, in that particular country, or

          (ii) upon expiration of the last to expire Licensed Patent covering
such Licensed Product in a country;

          (iv) if FOUNDATION abandons its patent solicitation efforts for all
Licensed Applications, and no issued Licensed Patent is in force.

                                       VII

                         ACCOUNTING AND PAYMENT SCHEDULE

     7.1 Payment, reporting and financial accounting shall be on a quarterly
basis and LICENSEE will deliver to the FOUNDATION within sixty (60) days after
the end of each quarter of the License Year a report in writing setting forth
sales of Licensed Products (including a negative report if appropriate) and will
accompany such report with an appropriate payment of royalty or maintenance fee
due for such period. LICENSEE will keep accurate records, certified by it,
showing the information by which LICENSEE arrived at a royalty determination and
upon FOUNDATION's written request, but not more frequently than once per
calendar year, will permit a person appointed by the FOUNDATION and acceptable
to LICENSEE after entering into a confidentiality agreement with LICENSEE, at
FOUNDATION's expense, to make such inspection of said records at agreed times
during LICENSEE's regular business hours for the sole purpose of and to the
extent necessary to verify royalty reports made by LICENSEE with respect to Net
Sales Price received not more than three (3) years prior to the date of
FOUNDATION's request. The report for the first quarter of the

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first License Year will include any sales of Licensed Products by LICENSEE prior
to the date of this Restated Agreement and will be accompanied by appropriate
payment of royalty therefor in the U.S. dollars. To the extent that LICENSEE
does not have the right to grant to FOUNDATION the right to audit its
sublicensees' books and records hereunder, LICENSEE shall endeavor to obtain for
itself such right and at the request and expense of FOUNDATION, LICENSEE shall
exercise such audit right with respect to sublicensees, and to the extent its
contractual obligations to the sublicensee permit, provide the results of such
audit for inspection by FOUNDATION pursuant to this Section 7.1.

     7.2 Conversion from foreign currencies, if any, shall be based upon the
conversion rate for conversion of the foreign currency into U.S. Dollars, quoted
for current transactions for buying U.S. Dollars, as reported in THE WALL STREET
JOURNAL for the last business day of the calendar quarter to which such payment
pertains.

     7.3 Payments which are delayed beyond the sixty (60) days after the end of
the quarter in which they become due shall bear interest at a rate equal to the
prime rate as reported by Chase Manhattan Bank, New York, calculated on the
number of days such payment is delinquent.

                                      VIII

                                      TERM

     8.1 The aforesaid exclusive license shall commence on April 1, 1993 and
unless terminated earlier pursuant to Article XIII, continue in full force and
effect on country-by-country and Licensed Product-by-Licensed Product basis
until the expiration, revocation or invalidation date of the last Licensed
Patent or of the abandonment of the last Licensed Application in such country,
whichever is later. LICENSEE's license with respect to Biological Research
Materials and Technical Information in each country shall survive the expiration
of this Restated Agreement and shall be deemed fully-paid as of such date.

                                       IX

                                DUTY OF DILIGENCE

     9.1 LICENSEE shall use its reasonable efforts to effect the introduction of
Licensed Product(s) into the commercial market as soon as practicable consistent
with sound and reasonable business practices. Upon and after such introduction
and consistent with sound and reasonable business practices, LICENSEE agrees to
continue to use its reasonable efforts to maximize commercial sales of Licensed
Products for the duration of the term of this Agreement. LICENSEE further agrees
to use reasonable best efforts to maintain quality control over Licensed
Products and generally attend to proper, safe, fair and lawful development and
exploitation of the market for Licensed Products. The foregoing diligence
requirements may be satisfied by LICENSEE or its sublicensees.

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                                        X

            INFRINGEMENT OF LICENSED PATENT RIGHTS BY THIRD PARTIES

     10.1 In the event that any infringement of a patent within the Sponsored
Research Intellectual Property Rights shall come to the attention of the
FOUNDATION or LICENSEE, then FOUNDATION and LICENSEE shall duly inform each
other. LICENSEE shall have the first right (itself or through others), at its
sole option, to bring suit to enforce the Sponsored Research Intellectual
Property Rights, and/or defend any declaratory judgment action with respect
thereto, in each case with respect to the manufacture, sale or use of a Licensed
Product; provided, however, that LICENSEE shall keep FOUNDATION reasonably
informed as to the defense and/or settlement of such action. FOUNDATION shall
have the right to participate in any such action with counsel of its own choice
at its own expense. If LICENSEE fails to initiate a patent infringement action
to enforce the Sponsored Research Intellectual Property Rights against a
commercially significant infringement by a third party, within * of a request by
FOUNDATION to do so, (or within such shorter period which may be required to
preserve the legal rights of FOUNDATION under the laws of the relevant
government), FOUNDATION may initiate such action at its own expense; provided,
prior to initiating any such action it shall notify LICENSEE of its intent to do
so and shall discuss with LICENSEE and reasonably take into consideration
LICENSEE's views as to whether such an action should then be pursued. LICENSEE
shall have the right to participate in any such action with counsel of its own
choice and its own expense.

     10.2 LICENSEE may credit any expenses (including, without limitation,
attorneys and expert fees) incurred in connection with any infringement or
declaratory judgment against up to * of any royalties payable by LICENSEE. Out
of any damages or awards recovered by LICENSEE in such action such amounts shall
be first applied to reimburse LICENSEE's and then FOUNDATION's unreimbursed
expenses, including without limitation, reasonable attorneys' and expert fees
and court costs. Any amount remaining belongs to *

     10.3 In any action brought by LICENSEE, LICENSEE undertakes to indemnify
for and hold FOUNDATION harmless from any damages, costs or expenses incurred by
reason of such litigation. LICENSEE shall not settle any claim based on the
infringement of a patent within the Sponsored Research Intellectual Property
Rights without the consent of FOUNDATION, which consent shall not be
unreasonably withheld.

                                       XI

                                   ASSIGNMENT

     11.1 The rights and obligations of the LICENSEE are not assignable without
the prior written consent of FOUNDATION, which consent shall not be unreasonably
withheld, except that LICENSEE may assign those rights and obligations without
such consent (i) to an Affiliate of LICENSEE, or (ii) to a successor in
connection with a sale of all or substantially all of LICENSEE's business or
assets relating to this Restated Agreement, whether by merger, operation of law
or

                                      -12-

<PAGE>

otherwise; provided that such assignee or transferee is not bankrupt and
promptly agrees in writing to be bound by the terms and conditions of this
Restated Agreement.

                                       XII

                                  SUBLICENSING

     12.1 LICENSEE may sublicense provided that: (i) FOUNDATION finds the
sublicensee generally acceptable, which such acceptance shall not be
unreasonably withheld, (ii) that all sublicensees shall be obligated to all the
terms and conditions of this Restated Agreement beneficial to or protective of
FOUNDATION, and (iii) that LICENSEE shall have the sublicensee guarantee
compliance on all such provisions. FOUNDATION hereby agrees that any Major
Pharmaceutical Company shall be an acceptable sublicensee of LICENSEE. As used
herein, "Major Pharmaceutical Company" shall be any of the top fifty (50)
pharmaceutical companies, ranked in order of worldwide pharmaceutical sales, as
published by Scrip in its most recent ranking prior to the grant of the
sublicense.

     12.2 Any sublicense granted by LICENSEE (including, without limitation, any
non-exclusive sublicense) shall remain in effect in the event of any termination
of this Restated Agreement and shall provide for the assignment of such
sublicenses to FOUNDATION or its designee, in the event that the Restated
Agreement is terminated; provided, the financial obligations of each sublicensee
to FOUNDATION shall be limited to the amounts LICENSEE shall be obligated to pay
to FOUNDATION for the activities of such sublicensee pursuant to this Restated
Agreement.

                                      XIII

                                   TERMINATION

     13.1 Either party may terminate this Restated Agreement for noncompliance
with a material term of this Restated Agreement by the other party by written
notice to the breaching party of its intentions to do so, if such breach is not
cured within ninety (90) days after such written notice is given. However, if
the party alleged to be in breach of this Restated Agreement disputes such
breach within such ninety (90) day period, the nonbreaching party shall not have
the right to terminate this Restated Agreement unless it has been determined by
an independent arbitrator that this Restated Agreement was materially breached,
and the breaching party fails to comply with its obligations hereunder within
ninety (90) days after such determination.

     13.2 LICENSEE may terminate this License Agreement, in its entirety or as
to any Licensed Patent or Licensed Application, or as to any particular Licensed
Product, or as to any country, at any time by giving FOUNDATION at least sixty
(60) days prior written notice.

     13.3 (a) Termination of this Restated Agreement for any reason shall not
release any party hereto from any liability which, at the time of such
termination, has already accrued to the other party or which is attributable to
a period prior to such termination nor preclude either party from

                                      -13-

<PAGE>

pursuing all rights and remedies it may have hereunder or at law or in equity
with respect to any breach of this Restated Agreement.

          (b) Upon termination of this Restated Agreement for any reason, each
party shall promptly return to the other party all Confidential Information
received from the other party (except one copy of which may be retained for
archival purposes).

          (c) In the event this Restated Agreement is terminated for any reason,
LICENSEE and its sublicensees shall have the right to sell or otherwise dispose
of the stock of any Licensed Product subject to Articles VI and VII hereof.

          (d) Articles I, VIII, X, XIV, XV and XVI and Sections 12.2 and 13.3
shall survive the expiration and any termination of this Restated Agreement.
Except as otherwise provided in this Article XIII, all rights and obligations of
the parties under this Restated Agreement shall terminate upon the expiration or
termination of this Restated Agreement.

                                       XIV

                          ARBITRATION AND JURISDICTION

     14.1 If a dispute arises out of or relates to this Restated Agreement, or
the breach thereof, and if said dispute cannot be settled through negotiation,
the parties agree first to try in good faith to settle the dispute by mediation
under the Commercial Mediation Rules of the American Arbitration Association
before resorting to arbitration.

     14.2 Subject to Section 14.3, any dispute under this Restated Agreement
(except any dispute relating to the validity or enforceability of any patent)
which is not settled by mutual consent shall be finally settled by binding
arbitration. Any such arbitration proceeding shall be conducted in accordance
with the Commercial Arbitration Rules of the American Arbitration Association
and shall be held in New York, New York, unless otherwise agreed by the parties.
The arbitration shall be conducted by an Arbitration Panel comprising three
neutral, independent arbitrators. One arbitrator shall be appointed by
FOUNDATION, one arbitrator shall be appointed by LICENSEE, and a Chairman of the
Arbitration Panel shall be appointed by the first two arbitrators. The members
of the Arbitration Panel shall have sufficient and appropriate education and
experience to competently address the matter submitted to the Arbitration Panel
for resolution. Judgment upon the arbitration award may be entered in any court
of competent jurisdiction. The costs of the arbitration including administrative
and arbitrators' fees, shall be shared equally by the parties and each party
shall bear its own costs and attorneys' and witness' fees incurred in connection
with the arbitration. No punitive damages may be granted by the arbitrators. The
arbitration proceedings and the decision shall not be made public without the
joint consent of the parties and each party shall maintain the confidentiality
of such proceedings and decision unless otherwise permitted by the other party.
The parties agree that the decision shall be the sole, exclusive and binding
remedy between them regarding any and all disputes, controversies, claims and
counterclaims presented to the arbitrators.

                                      -14-

<PAGE>

Any award may be entered in a court of competent jurisdiction for a judicial
recognition of the decision and an order of enforcement.

     14.3 The FOUNDATION reserves the right and power to proceed with direct
judicial remedies against LICENSEE without conciliation, mediation or
arbitration for breach of the royalty payment and sales reporting provisions of
this Restated Agreement after giving written notice of such breach to LICENSEE
followed by an opportunity period of * in which to cure such breach. In
collecting overdue royalty payments and securing compliance with reporting
obligations, FOUNDATION may use all judicial remedies available.

                                       XV

                                 CONFIDENTIALITY

     15.1 Except as expressly provided herein or as required by law, the parties
agree that, for the term of this Restated Agreement and for * thereafter, the
receiving party shall keep completely confidential and shall not publish or
otherwise disclose and shall not use for any purpose except for the purposes
contemplated by this Restated Agreement any Confidential Information furnished
to it by the disclosing party hereto pursuant to this Restated Agreement, except
that to the extent that it can be established by the receiving party by
competent proof that such Confidential Information:

          15.1.1 was already known to the receiving party, other than under an
obligation of confidentiality, at the time of disclosure;

          15.1.2 was generally available to the public or otherwise part of the
public domain at the time of its disclosure to the receiving party;

          15.1.3 became generally available to the public or otherwise part of
the public domain after its disclosure and other than through any act or
omission of the receiving party in breach of this Restated Agreement;

          15.1.4 was independently developed by the receiving party as
demonstrated by documented evidence prepared contemporaneously with such
independent development; or

          15.1.5 was subsequently lawfully disclosed to the receiving party by a
person other than a party hereto.

     15.2 Each party hereto may use or disclose information disclosed to it by
the other party to the extent such use or disclosure is reasonably necessary in
filing or prosecuting patent applications, prosecuting or defending litigation,
complying with applicable governmental regulations or otherwise submitting
information to tax or other governmental authorities, conducting clinical
trials, or making a permitted sublicense or otherwise exercising its rights
hereunder, provided that if a party is required to make any such disclosure of
another party's confidential information, other than pursuant to a
confidentiality agreement, it will give reasonable advance notice to the latter
party of

                                      -15-

<PAGE>

such disclosure and, save to the extent inappropriate in the case of patent
applications, will use its best efforts to secure confidential treatment of such
information prior to its disclosure (whether through protective orders or
otherwise).

     15.3 Except as expressly provided herein, each party agrees not to disclose
any terms of this Restated Agreement to any third party without the consent of
the other party; provided, reasonable disclosures may be made as required by
securities or other applicable laws or other federal or national agency
requirements, or to actual or prospective investors or corporate partners, or to
a party's accountants, attorneys and other professional advisors. Once a
disclosure has been approved, LICENSEE may make disclosures which do not
materially differ therefrom without obtaining approvals from FOUNDATION.

                                       XVI

                                      OTHER

     16.1 LICENSEE acknowledges that title to all Biological Research Materials
remains in FOUNDATION and that LICENSEE's possession of Biological Research
Materials under this Agreement is by way of bailment and not conditional or
unconditional sale. Upon termination for cause by FOUNDATION or termination by
LICENSEE under Article XIII, LICENSEE agrees to destroy or return all Biological
Research Materials to FOUNDATION and FOUNDATION shall destroy or return to
LICENSEE all "Sponsor Materials" (as defined in the Sponsored Research
Agreements) and any other materials provided by LICENSEE and its sublicensees
unless provided otherwise in any prevailing biological materials agreements
between the parties. At the natural termination of this Agreement (Article
VIII), LICENSEE shall have the right to continue to possess and use the
Biological Research Materials for any and all purposes without additional
payment.

     16.2 LICENSEE agrees that it will not use the indicia or names of
FOUNDATION or any of its personnel in advertising, promotion, or labeling of
Licensed Products without prior written approval of the FOUNDATION, which
approval shall not be unreasonably withheld.

     16.3 FOUNDATION represents and warrants that (i) FOUNDATION is and shall
remain the exclusive owner of the entire right, title, and interest in and to
Licensed Patents and Licensed Applications (and co-owner with LICENSEE of all
right, title and interest in and to the Joint Inventions and related Licensed
Patents and Licensed Applications) and Sponsored Research Intellectual Property
Rights; (ii) FOUNDATION has the sole right and authority to enter into this
Restated Agreement and grant the rights and licenses hereunder; (iii) FOUNDATION
has not previously granted and will not grant any rights in the Licensed
Patents, Licensed Applications and Sponsored Research Intellectual Property
Rights that are inconsistent with the rights and licenses granted to LICENSEE
herein; (iv) there are no pending or threatened actions, suits, investigations,
claims or proceedings in any way related to the Licensed Patents, Licensed
Applications and Sponsored Research Intellectual Property Rights; (v) the
Licensed Patents, Licensed Applications and Sponsored Research Intellectual
Property Rights are free and clear of any lien, encumbrance, security interest
and restriction on transfer and license; and (vi) FOUNDATION has and shall

                                      -16-

<PAGE>

comply fully with 35 U.S.C. (S)(S)200 ET SEQ. and all implementing regulations
necessary to perfect its ownership interest in the Licensed Patents, Licensed
Applications and Sponsored Research Intellectual Property Rights.

     16.4 EXCEPT AS PROVIDED IN SECTION 16.3 AND THE WHEREAS CLAUSES, NEITHER
PARTY MAKES ANY REPRESENTATIONS OR WARRANTIES (EXPRESS, IMPLIED, STATUTORY OR
OTHERWISE) WITH RESPECT TO THE SUBJECT MATTER HEREOF, AND FOUNDATION MAKES NO
EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE.

     16.5 FOUNDATION by this Restated Agreement makes no representation as to
the patentability and/or breadth of the inventions and/or discoveries involved
in the Licensed Patents, Licensed Applications and Sponsored Research
Intellectual Property Rights.

     16.6 LICENSEE agrees to defend, indemnify and hold FOUNDATION harmless from
and against all liability, damages, expenses or losses for death, personal
injury, illness or property damage (including reasonable attorney's fees)
resulting from a claim, suit or proceeding brought by a third party against
FOUNDATION and arising (a) out of use by LICENSEE or its sublicensees of
inventions licensed or information furnished under this Restated Agreement, or
(b) out of any use, sale or other disposition by LICENSEE or its sublicensees of
Licensed Products made by use of such inventions or information; provided that
any indemnitee that intends to claim indemnification under this Article XVI
shall: (i) promptly notify LICENSEE in writing of any claim with respect to
which the indemnitee intends to claim such indemnification, (ii) give LICENSEE
sole control of the defense and settlement thereof, and (iii) provide LICENSEE,
at LICENSEE's expense, with reasonable assistance and full information with
respect to such claim. LICENSEE shall have no obligation for any claim if the
indemnitee seeking indemnification makes any admission, settlement, or other
communication regarding such claim without the prior consent of LICENSEE, which
consent will not be unreasonably withheld. As used in this clause, FOUNDATION
includes its trustees, officers, agents and employees, and those of Cornell
University (including CUMC) and affiliated hospitals, clinics, or other
institutions affiliated with CUMC, and "LICENSEE" includes its Affiliates,
contractors and sub-contractors. In discharge of the above, LICENSEE will
maintain general liability insurance in the amount of at least one million
($1,000,000) per occurrence with a deductible of more than $10,000 per
occurrence against damage to or destruction of property and injury to or death
of individuals and against such other risks as FOUNDATION may reasonably request
arising out of or in connection with any of the Licensed Products, FOUNDATION,
LICENSEE and their respective officers, trustees, members of their governing
boards, and employees will be named insureds under all such insurance. Such
insurance will also provide that FOUNDATION will be given notice of any material
modification thereof which would reduce insurance coverage of LICENSEE, and at
least thirty (30) days prior written notice of cancellation or termination and
reason therefore. LICENSEE will furnish FOUNDATION upon request, and in any
event on execution of this Restated Agreement and on each anniversary of the
Effective Date of this Restated Agreement, written confirmation issued by the
insurer or an independent insurance agent confirming that insurance is
maintained in accordance with the above requirements.

                                      -17-

<PAGE>

     16.7 This Restated Agreement shall be interpreted under the Laws of the
State of New York.

     16.8 Any payment, report, notice or other communication required or
permitted to be given to either party hereto shall be deemed to have been
properly given and to be effective on the date of delivery if delivered in
person or telecopied (with confirmed answerback) to the number provided by the
other party, or five (5) days after mailing in the United States by certified
first-class United States mail, postage paid, return receipt requested, to the
other party's address as set forth below or to such other address as a party
shall designate by written notice to the other party.

To FOUNDATION:      H. Walter Haeussler, President
                    CORNELL RESEARCH FOUNDATION, INC.
                    Cornell Business & Technology Park
                    20 Thornwood Drive, Suite 105
                    Ithaca, New York 14850

To LICENSEE:        GENVEC, INC.
                    12111 Parklawn Drive
                    Rockville, Maryland 20852
                    Attn:  President
                    with a copy to:  Vice President, Corporate Development

     16.9 LICENSEE's sole obligation to exploit the Licensed Patents, Licensed
Applications and Sponsored Research Intellectual Property Rights is as set forth
in Article IX. Nothing in this Restated Agreement will impair LICENSEE's right
to independently acquire, license, develop for itself, or have others develop
for it, similar technology performing similar functions as the Licensed
Technology or to market and distribute products based on such other technology.

     16.10 The relationship of FOUNDATION and LICENSEE established by this
Restated Agreement is that of independent contractors. Nothing in this Restated
Agreement shall be construed to create any other relationship between FOUNDATION
and LICENSEE. Neither party shall have any right, power or authority to assume,
create or incur any expense, liability or obligation, express or implied, on
behalf of the other.

     16.11 Any delays in or failures of performance by either party under this
Restated Agreement shall not be considered a breach of this Restated Agreement
if and to the extent caused by occurrences beyond the reasonable control of the
party affected, including but not limited to: acts of God, acts, regulations or
laws of any government, strikes or other concerted acts of workers, fires,
earthquakes, floods, explosions, riots, wars, rebellion, and sabotage. Any time
period for performance imposed hereunder shall be extended by the actual time of
delay caused by any such occurrence.

     16.12 A waiver, express or implied, by either FOUNDATION or LICENSEE of any
right under this Restated Agreement or of any failure to perform or breach
hereof by the other party hereto

                                      -18-

<PAGE>

shall not constitute or be deemed to be a waiver of any other right hereunder or
of any other failure to perform or breach hereof by such other party, whether of
a similar or dissimilar nature thereto.

     16.13 SUBJECT TO SECTION 16.6, NEITHER PARTY SHALL BE LIABLE TO THE OTHER
PARTY OR ANY THIRD PARTY FOR ANY INDIRECT, SPECIAL, CONSEQUENTIAL OR EXEMPLARY
DAMAGES (INCLUDING LOST OR ANTICIPATED REVENUES OR PROFITS RELATING TO THE
SAME), ARISING FROM ANY CLAIM RELATING TO THIS RESTATED AGREEMENT, WHETHER SUCH
CLAIM IS BASED ON CONTRACT, TORT OR ANY THEORY OF LIABILITY.

     16.14 Headings included herein are for convenience only, do not form a part
of this Restated Agreement and shall not be used in any way to construe or
interpret this Restated Agreement.

     16.15 If any provision of this Restated Agreement shall be found by a court
to be void, invalid or unenforceable, the same shall be reformed to comply with
applicable law, or stricken if not so conformable, so as not to affect the
validity or enforceability of the remainder of this Restated Agreement.

     16.16 This Restated Agreement shall be binding upon and inure to the
benefit of and be enforceable by the parties hereto and their respective
successors and permitted assigns.

     16.17 At any time or from time to time on and after the date of this
Restated Agreement, either party shall at the request of the other party (i)
deliver to the other party such records, data or other documents consistent with
the provisions of this Restated Agreement, (ii) execute, and deliver or cause to
be delivered, all such consents, documents or further instruments of transfer or
license, and (iii) take or cause to be taken all such actions, as the other
party may reasonably deem necessary or desirable in order for the other party to
obtain the full benefits of this Restated Agreement and the transactions
contemplated hereby.

     16.18 LICENSEE and LICENSOR have each consulted counsel of their choice
regarding this Restated Agreement, and each acknowledges and agrees that this
Restated Agreement shall not be deemed to have been drafted by one Party or
another and will be construed accordingly.

     16.19 This Restated Agreement, together with the Sponsored Research
Agreements and Material Transfer Agreement, constitute the entire understanding
and agreement between the parties with respect to the subject matter hereof and
supersedes any and all prior negotiations, representations, agreements, and
understandings, written or oral, that the parties may have reached with respect
to the subject matter hereof. No agreements altering or supplementing the terms
hereof may be made except by means of a written document signed by the duly
authorized representatives of each of the parties hereto. It is understood that
the Sponsored Research Agreements and Material Transfer Agreement are separate
and independent from this Restated Agreement and termination of any of such
agreements shall not operate to terminate or otherwise affect the rights and
obligations of the parties under the other agreements.

                                      -19-

<PAGE>

     16.20 This Restated Agreement may be executed in counterparts, each of
which shall be deemed an original, but both of which together shall constitute
one and the same instrument.

     IN WITNESS WHEREOF, the parties have caused this instrument to be executed
in duplicate as of the day and year first above written.

ATTEST:                                 CORNELL RESEARCH FOUNDATION, INC.

                                        By
--------------------------------           -------------------------------------
                                        H. Walter Haeussler

                                        Title      President

                                        Date
                                             -----------------------------------

ATTEST:                                 GENVEC, INC.

                                        By
--------------------------------           -------------------------------------
                                        Title
                                              ----------------------------------
                                        Date
                                             -----------------------------------

                                      -20-<PAGE>

                               MOR BENNINGTON LLLP
                                 LEASE AGREEMENT
                            65 West Watkins Mill Road
                              Single-Story Building

         THIS LEASE AGREEMENT (this "Lease") is made as of the 4th day of May
1999, between

MOR BENNINGTON LLLP, a Maryland limited liability limited partnership
("Landlord"), and GENVEC, INC., a Delaware corporation ("Tenant").

         I.       LEASED PREMISES
                  ---------------

                  A.       LOCATION OF LEASED PREMISES. Landlord leases to
Tenant and Tenant leases from Landlord the "Leased Premises", comprised of the
entire single story building (the "Building"), containing approximately
forty-two thousand nine hundred (42,900) rentable square feet, located at 65
West Watkins Mill Road, Gaithersburg, Maryland 20879 in the Bennington
Corporate Center in Gaithersburg, Montgomery County, Maryland. The Leased
Premises are described more specifically in the attached EXHIBIT A which is
the site plan as approved by the City of Gaithersburg Planning Commission on
June 30, 1998. "Property", when used in this Lease, means the Building; Parcel
H upon which the Building is situated; and, all fixtures, equipment and other
improvements in or upon such land and/or Building, including sidewalks,
areaways, parking areas (subject to the parking easement whereby fifty-seven
(57) parking spaces located on Parcel H are designated for the benefit of
Parcel J as identified on Exhibit A), loading areas, gardens and lawns. SEE
RIDER NO. 1 -- Right of First Refusal, and RIDER NO. 2 -- Building Expansion
Space.

                  B.       CONSTRUCTION OF THE LEASED PREMISES.

                           1.       CONSTRUCTION OF BASE BUILDING. Landlord,
at its sole cost and expense, has completed construction of the base shell of
the Building (the "Base Building") in accordance with plans and specifications
attached hereto as Exhibit B and incorporated by reference herein (the "Base
Building Plans and Specifications"). Additionally, all systems development
charges for the Base Building hook-up and tap fees for six (6) toilets and six
(6) sinks and all costs for the two inch existing water meter, shall be paid
by Landlord. Landlord agrees that Landlord shall bear full responsibility for
the Base Building, and Base Building Plans and Specifications, as being in
compliance with all applicable requirements of law in effect as of the
Commencement Date, as hereafter defined, including without limitation, the
requirements of the law known as the Americans with Disabilities Act and the
regulations promulgated thereunder (the "ADA").

                           2.       CONSTRUCTION OF TENANT IMPROVEMENTS.
Tenant shall hire Gaudreau, Inc., or another architect and engineer acceptable
to Landlord who shall design the plans and specifications for the finishing of
the Leased Premises (the "Tenant Improvements"). Tenant acknowledges that it
has received and reviewed all information necessary from Landlord and
Landlord's representatives with respect to the Base Building, in order for
Tenant's architect and engineer to complete the plans and specifications for
the finishing of the Leased Premises (the "TI Plans and Specifications"). The
TI Plans and Specifications are subject to the prior written approval of
Landlord and Landlord's architect, which approvals shall not be unreasonably
withheld or conditioned. Landlord shall notify Tenant within seven (7)
calendar days following submission of the TI Plans and Specifications to
Landlord of Landlord's approval or disapproval of same or of Landlord's
requirement for and estimate of

<PAGE>

additional time to review the plans and specifications. Failure to respond to
Tenant's request for approval within such seven calendar day period, shall be
deemed to constitute approval thereof. The TI Plans and Specifications, when
approved, shall be initialled by the parties, shall be attached hereto as
"Exhibit C" and shall be incorporated into this Lease by reference. Subject to
and except as otherwise provided in this Lease and further subject to and
except for Landlord's responsibility for the Base Building Plans and
Specifications and Base Building, Tenant shall bear full responsibility for
the TI Plans and Specifications and the improvements to the Leased Premises
constructed in accordance with the TI Plans and Specifications, as being in
compliance with all applicable requirements of law, including without
limitation, the ADA, as amended. Tenant releases Landlord from any claim by
Tenant arising out of failure of the Leased Premises to be in compliance with
all applicable requirements of law.

                           Landlord shall contribute  Twenty-Eight  Dollars
and Fifty Cents ($28.50) multiplied by the Rentable Area of the Leased
Premises ("Landlord's Initial Contribution") toward the cost of the Tenant
Improvements, including Tenant's architectural and engineering design fees,
and the cost of exterior signage (the "Leased Premises Cost"). After the TI
Plans and Specifications are approved, Landlord shall construct the Tenant
Improvements and finish the Leased Premises for Tenant in accordance with the
TI Plans and Specifications and the terms of the Tenant Improvements
Construction Agreement hereinafter defined. The Leased Premises Cost shall
include the total cost of all labor and materials incurred by Landlord in
connection with finishing the Leased Premises, plus a fee of five percent (5%)
of all hard costs in connection therewith, plus an additional general
conditions fee of One Hundred Fourteen Thousand Dollars ($114,000) in
connection therewith. In the event the Leased Premises Cost exceeds Three
Million Dollars ($3,000,000.00), Landlord shall credit Tenant with sixty-seven
percent (67%) of that portion of the general contractor's fee payable to
Landlord's contractor (as discussed above) which exceeds One Hundred Fifty
Thousand Dollars ($150,000.00), up to a maximum credit of Sixty-Seven Thousand
Dollars ($67,000.00). For example, in the event the Leased Premises Cost is
$5,000,000.00, said credit to Tenant shall be $67,000.00. ($5,000,000 x .05 =
$250,000.00. $250,000,00 - $150,000.00 = $100,000. $100,000 x .67 =
$67,000.00). Said credit shall be applied first to Tenant Improvements and
then to installments of Basic Annual Rent due under this Lease.

                           Subject to the following, any charges and expenses
incurred for work and material respecting the finishing of the Leased Premises
which are in excess of Landlord's Initial Contribution, up to Fifty-Seven
Dollars ($57.00) multiplied by the Rentable Area of the Leased Premises
("Tenant's Minimum Contribution"), shall be paid by Tenant. In the event that
the total cost of Tenant Improvements exceeds the amount of Landlord's Initial
Contribution and Tenant's Minimum Contribution (i.e., $85.50 p.s.f.), and
provided Tenant has fulfilled its obligations with respect to Tenant's Minimum
Contribution, all charges and expenses incurred for work and material
respecting the finishing of the Leased Premises over and above such amount,
shall be initially shared equally by Landlord and Tenant with a maximum
additional Landlord contribution of Twenty Dollars ($20.00) per rentable
square foot of the Leased Premises ("Landlord's Additional Contribution").
Landlord's Additional Contribution, if any, shall be repaid by Tenant to
Landlord in equal monthly installments together with the monthly rent
payments, which installments shall be determined by amortizing Landlord's
Additional Contribution, together with interest at the rate of ten and
one-half percent (10.5%) per annum, over the original ten year

                                      -2-

<PAGE>

term of this Lease. Any costs in connection with the finishing of the Leased
Premises in excess of Landlord's Initial Contribution, Landlord's Additional
Contribution and Tenant's Minimum Contribution shall be paid by Tenant. For
example, if the Rentable Area of the Leased Premises is determined to be
42,900 square feet and the total cost of the Tenant Improvements is
$5,000,000.00, then Landlord's total contribution to the Tenant Improvements
would be $1,888,675.00, calculated as follows:

         Landlord's Initial Contribution of $1,222,650.00 (i.e. $28.50 x 42,900)
         is applied first toward the cost of the Tenant Improvements. [The next
         $2,445,300.00 (i.e. Tenant's Minimum Contribution of $57.00 per square
         foot) for the cost of the Tenant Improvements is the Tenant's
         responsibility].

         At this point the remaining Tenant Improvements costs would be
         $1,332,050.00 [i.e. $5,000,000.00 - $3,667,950.00 (Landlord's Initial
         Contribution plus Tenant's Minimum Contribution) = $1,332,050.00].

         Provided Tenant has fulfilled its obligations with respect to Tenant's
         Minimum Contribution, Landlord shall contribute up to $20.00 per square
         foot toward the remaining $1,332,050.00, on a shared dollar for dollar
         basis with Tenant. In this example the $20.00 ceiling would not be
         reached, and Landlord's Additional Contribution would be $666,025.00
         (i.e. 1/2 of $1,332,050.00).

                           Tenant's Minimum Contribution,  and all other
Tenant contributions for improvements to be made hereunder, shall be paid as
additional rent, within thirty (30) days of Tenant's receipt of invoices(s)
from Landlord. Tenant's failure to pay any amount due hereunder will be deemed
a default of this Lease.

                           Other matters related to the construction of the
Tenant Improvements, not addressed in this Lease, shall be governed by the
Tenant Improvements Construction Agreement attached hereto as Exhibit D-1 and
incorporated herein by reference (the "Tenant Improvements Construction
Agreement") to be entered into between Landlord and Tenant simultaneously with
their execution of this Lease.

                  C.       LANDLORD'S WARRANTY. Landlord hereby agrees to and
will assign to Tenant at the termination of Landlord's Warranty Period (as
defined below), to the extent they are assignable, any and all written
warranties and guarantees from Landlord's contractors, subcontractors and
suppliers of any materials and equipment installed by Landlord and labor to
the Leased Premises for that portion, if any, of the Lease Term that such
warranties and guarantees are in effect. With regard to any new construction
performed by Landlord for the benefit of Tenant pursuant to Paragraph I.B. of
this Lease, Landlord hereby warrants ("Landlord's Warranty") to Tenant that
Landlord will be responsible for a period ("Landlord's Warranty Period") of
one (1) year from the date on which the Leased Premises are substantially
complete (as determined in accordance with Section II.A. below) to repair or
to have repaired all defects in such construction, to the extent such defects
are not caused by the negligence of Tenant or any of its agents, servants,
employees or contractors (in which event such defects will be repaired at
Tenant's sole cost). To the extent that Landlord is obligated to make repairs
pursuant to Landlord's Warranty, Tenant will be relieved during Landlord's
Warranty Period of the obligations imposed upon it pursuant to this Lease to
make or pay for such repairs to the Leased Premises. Tenant agrees to and will
give Landlord prompt notice of the need for any such repairs.

                                      -3-

<PAGE>

         II.      LEASE TERM
                  ----------

                  A.       LEASE TERM.

                           1.       ORIGINAL LEASE TERM. The Lease Term will
be approximately ten (10) years, beginning on the "Commencement Date" as
hereinafter defined, and terminating at 11:59 p.m. on the last day of the
tenth (10th) full Lease Year unless the Lease Term is extended in accordance
with the following paragraph, renewed or terminated earlier in accordance with
this Lease. The Commencement Date shall be the earlier of November 1, 1999 or
the date on which the Leased Premises are substantially completed as mutually
certified by Landlord and Tenant's architect and a certificate of occupancy
has been issued for, or the final inspection has occurred allowing occupancy
of, the Leased Premises. Notwithstanding the foregoing, if the completion of
the Leased Premises is delayed due to Tenant's failure to meet the deadlines
(the "Tenant Deadlines") outlined on Exhibit D-2 attached hereto and made a
part hereof, the Commencement Date shall, nonetheless, be November 1, 1999.
The Commencement Date will be confirmed in a supplementary written agreement,
in substantially the form attached as EXHIBIT E. Unless specifically stated
otherwise in this Lease, the term "Lease Term" means the original term of ten
(10) years plus any "Extended Lease Term" as defined below and any and all
renewal terms, whenever a renewal option has been exercised. SEE RIDER NO. 3
-- Renewal Option.

SEE INSERT X

                           2.       EXTENDED LEASE TERM. Tenant shall have the
one-time right to extend the original term of this Lease up to a maximum of
four (4) additional years and, in any event, in no less than full year
increments, (and the term "Lease Term" will refer to the Lease Term, as so
extended) by providing Landlord with written notice of its exercise of this
right by the end of the fourth (4th) Lease Year. Landlord shall provide Tenant
an allowance equal to One Dollar ($1.00) multiplied by the Rentable Area of
the Leased Premises for each year that the Lease Term is extended, to be used
by Tenant solely to refurbish the Leased Premises (the "Extended Lease Term
Allowance"). The Extended Lease Term Allowance shall be paid by Landlord to
Tenant at the end of the fifth Lease Year after Tenant provides Landlord with
detailed invoices, marked "PAID", for the work completed hereunder, together
with final lien waivers from all contractors and subcontractors.

                  B.       INTENTIONALLY DELETED.

                  C.       LEASE YEAR. The term "Lease Year" means each
consecutive period of twelve (12) successive calendar months during the Lease
Term. If the Commencement Date does not occur on the first day of a month, the
first Lease Year will include the twelve calendar months and the period from
the Commencement Date until the first day of the following month.

                  D.       ACCEPTANCE OF LEASED PREMISES. Upon delivery by
Landlord to Tenant of the Leased Premises, Tenant will be deemed to have
accepted the Leased Premises. However, Landlord will remain responsible for
the completion of those "punchlist" items, if any, to which Landlord and
Tenant have agreed in writing within fifteen (15) days after the Leased
Premises are substantially

                                      -4-

<PAGE>

             Insert X to Section II.A. (Lease Term) of Genvec Lease

         Notwithstanding anything in this Lease or the Tenant Improvements
Construction Agreement to the contrary, if the failure to deliver the Leased
Premises in substantially complete condition by December 17, 1999 (as such
date may be extended in accordance with the Tenant Improvements Construction
Agreement) is solely and directly as a result of matters within Landlord's
reasonable control (a "Landlord Delay"), then, for each day beyond December
17, 1999 (or such date to which the substantial completion date on Exhibit D-3
may be extended) during which such completion is delayed as a result of a
Landlord Delay, Tenant shall be entitled to a day-for-day abatement of the
Basic Annual Rent and Common Area Expenses (the "Landlord Delay Abatement").
The foregoing shall not affect Tenant's obligation to commence its rental
payments on November 1, 1999, it being the intention of the parties that the
Landlord Delay Abatement shall be applied, if at all, to the first rental
payments to come due after substantial completion of the Leased Premises has
occurred.

                                     Landlord Initials: /s/ Signature Illegible
                                       Tenant Initials: /s/ Signature Illegible

                                      -4a-

<PAGE>

complete. Landlord shall use its commercially reasonable efforts to cause such
punchlist items to be completed within thirty (30) days thereafter.

         III.     RENT AND FINANCIAL MATTERS
                  --------------------------

                  A.       DEPOSIT. Tenant shall deposit with Landlord at the
time of execution of this Lease a "Deposit" of Fifty-One Thousand Eight
Hundred Thirty-Seven Dollars and Fifty Cents ($51,837.50). Landlord's receipt
of the Deposit shall be confirmed by Landlord in the Lease Commencement
Agreement, and the Deposit shall not be deemed to have been paid by Tenant
unless and until Landlord's receipt thereof is so confirmed. The Deposit,
which to the extent the same has not been applied or exhausted pursuant to the
further terms hereof, shall be applied by Landlord to the payment of the first
full month's installment of Basic Annual Rent due hereunder. Landlord shall
have the right to apply the Deposit to cure any breach by Tenant of any of
Tenant's obligations or duties pursuant to this Lease prior to the application
thereof by Landlord to the first full month's installment of Basic Annual Rent.

                  B.       RENTAL PAYMENTS. Tenant agrees to pay Landlord
Basic Annual Rent as set forth below (subject to adjustment following the
measurement described in III.C.1.(a) below):

<TABLE>
<CAPTION>

                                      Basic                              Monthly                                 Per
         Lease Year                 Annual Rent                        Installments                         Square Foot
         <S>                        <C>                                <C>                                  <C>

              1                     $622,050.00                        $51,837.50                               14.50
              2                     $640,926.00                        $53,410.50                               14.94
              3                     $660,231.00                        $55,019.25                               15.39
              4                     $679,965.00                        $56,663.75                               15.85
              5                     $700,557.00                        $58,379.75                               16.33
              6                     $721,578.00                        $60,131.50                               16.82
              7                     $743,028.00                        $61,919.00                               17.32
              8                     $765,336.00                        $63,778.00                               17.84
              9                     $788,502.00                        $65,708.50                               18.38
              10                    $812,097.00                        $67,674.75                               18.93

</TABLE>

In the event that the Lease Term is extended pursuant to Section II.A.2.
above, Basic Annual Rent shall continue to increase at the rate of three
percent (3%) per Lease Year for the balance of the Lease Term.

Basic Annual Rent shall be paid in equal monthly installments as set forth
above. Each installment of the Basic Annual Rent is due in advance on the
first (1st) day of each and every month for which payment is due. All payments
of Basic Annual Rent, Additional Rent or other sums due Landlord under this
Lease will be made by Tenant without any deductions or set-offs and without
demand, at the address designated in this Lease for such payments, or at any
other address that Landlord designates by not less than fifteen (15) days
advance written notice to Tenant. Unless specifically stated otherwise in this
Lease, the term "Rent" means Basic Annual Rent and Additional Rent. Because
Landlord will incur additional expenses if Tenant does not pay the Rent on the
date due, should payment of any installment of Rent be more than five (5)
business days' delinquent, Tenant will pay a late charge equal to five percent
(5%) of the arrearage. Landlord, however, agrees to waive payment of such late
charge provided the number of such delinquent payments does not exceed one (1)
delinquency in any twelve (12) month period. In addition, the arrearage shall
bear interest calculated at the rate of eighteen percent (18%) per annum for
each day such a payment is late. The late charge will be payable at the same
time as the late payment, without demand.

                                       -5-
<PAGE>

Time is of the essence respecting all payments to be made by Tenant to
Landlord under this Lease.

                           If the Lease Term begins on a day other than the
first day of a month, then on the Commencement Date the monthly installment of
Basic Annual Rent, Additional Rent, and all amounts set forth in Paragraph
III.C.2. or otherwise payable by Tenant shall be prorated.

                           The term "Additional Rent" includes all payments or
installments due under this Lease other than Basic Annual Rent (including
attorneys' fees incurred by Landlord in connection with Tenant's default).
Unless a different period for payment is provided for elsewhere in this Lease,
any Additional Rent due will be paid by Tenant within thirty (30) days after
Landlord has notified Tenant of the amount due. Tenant's obligation for
Additional Rent and any unpaid Basic Annual Rent will remain in effect after
the termination or expiration of this Lease.

                  C.       RENT ADJUSTMENTS.

                           1.       DEFINITIONS. For purposes of this Lease,
the following meanings or definitions shall apply:

                                    (a)     The "Rentable  Area of the Leased
Premises" and the "Rentable Area of the Building" are each approximately
forty-two thousand nine hundred (42,900) square feet. Therefore, "Tenant's
Portion" of those expenses payable in accordance with Paragraph III.C.2. is
one hundred percent (100%). The exact square footage of the Rentable Area of
the Leased Premises and the Rentable Area of the Building shall be verified in
accordance with the Washington, D.C. Association of Realtors by Tenant's
architect prior to the commencement of construction of the Tenant Improvements.

                                    (b)     The term "Common Area Expenses"
means the following expenses paid or incurred by Landlord in connection with
Landlord's management of the Building and/or the Property and the maintenance,
operation and repair of the common areas of the Property: (i) keeping the
driveways, parking areas, sidewalks and steps free and clear of ice, snow and
debris; (ii) maintaining all grass and landscaping on the Property; (iii)
maintaining the common areas of the Building, including the common utility
rooms and common security systems, if any, and repair of normal wear and tear
of the roof and caulking; (iv) the cost of Insurance; (v) repair of the paving
the driveways and parking areas; (vi) monitoring, repairing and payment of all
common utilities, including water, sewerage, unmetered or metered sprinkler
and exterior electrical utilities on the Property; (vii) management fees;
(viii) charges or assessments imposed on or allocated to the Building and/or
Property by the Bennington Corporate Center Association, Inc.; (ix) the cost
of any capital improvement (amortized or depreciated over the useful life of
such improvement as defined by GAAP; with the interest at a fluctuating rate
per annum which is at all times equal to 1-1/2% over the prime interest rate
as determined from time to time by Citibank, N.A. on the unamortized balance)
made to the Building by Landlord which results in more efficient operation of
the Building or made to the Building by Landlord after the date of this Lease
that is required under any governmental law or regulation that was not
applicable to the Building at the time it was constructed; and (x) all other
items which would be considered as procured or incurred in maintaining,
operating, or repairing the Building or the common areas of the Property under
sound management and generally accepted accounting principles. "Common Area
Expenses" does not include the cost of work Landlord performs for, and/or at
the expense of, any particular tenant (including Tenant), which costs

                                      -6-

<PAGE>

will be billed directly to Tenant or such other tenant, as the case may be.
Notwithstanding anything in the Lease to the contrary, Common Area Expenses
also shall not mean and shall exclude any and all fees, charges,
disbursements, obligations, Base Rent, Additional Rent, costs and expenses not
reasonably related to the maintenance, repair, management and/or operation of
the Building and the Property, such exclusions, without limitation, including
the following:

                           1.       Financing Costs. Any and all of Landlord's
                                    payments for (a) loan principal or interest,
                                    together with expenses thereto related in
                                    connection with such financing or any
                                    refinancing during the term of the Lease,
                                    (b) payments pursuant to ground leases,
                                    legal fees related to the preparation and
                                    review of easements, license agreements, and
                                    payments pursuant to any other agreements to
                                    the extent such payments do not constitute
                                    operating expenses under generally accepted
                                    accounting principles (c) charges, rentals,
                                    obligations or payments of any kind for the
                                    financing of the construction of the Tenant
                                    Improvements except as specifically set
                                    forth herein or (d) similar payments;

                           2.       Landlord's Taxes, Licenses and Fees. Any and
                                    all of Landlord's income, excise, franchise
                                    taxes, excess profit taxes, or similar taxes
                                    on Landlord's business; license and other
                                    fees relating to Landlord's business; any
                                    other fees and taxes not constituting real
                                    estate taxes which do not uniquely pertain
                                    to the Leased Premises, the Building or the
                                    Property or Tenant's specific use thereof;
                                    and any taxes or fees not levied in
                                    substitution for real estate taxes;

                           3.       Salaries. Wages, salaries and benefits of
                                    employees over the rank of the property
                                    manager except to the extent those employees
                                    are directly involved in the day-to-day
                                    management and operation of the Building;

                           4.       Leasing Costs. Any and all of Landlord's
                                    costs to lease space in the Property to all
                                    prior, existing and prospective tenants,
                                    including, without limitation: consulting
                                    and marketing fees, advertising expenses,
                                    brokerage commissions, legal fees, vacancy
                                    costs, rent or other rent concessions,
                                    and/or refurbishment or improvement
                                    expenses; and costs of preparing, improving
                                    or altering any space in preparation for
                                    occupancy of any new or renewal tenant; rent
                                    for management or leasing offices;

                           5.       Related Party Fees. Wages, salaries, fees
                                    and fringe benefits paid to administrative
                                    or executive personnel or officers or
                                    partners of Landlord unless employed at
                                    competitive rates as independent
                                    contractors; any other operating expense
                                    representing an amount paid to a related
                                    corporation, entity or person that is in
                                    excess of the amount that would be paid in
                                    the absence of such relationship;

                                      -7-

<PAGE>

                           6.       Depreciation. Any charge for depreciation of
                                    the Building or other improvements
                                    comprising part of the Property or equipment
                                    and any interest or other financing charge;

                           7.       Building Defects. The cost of correcting
                                    defects in the construction of the Building
                                    or in the installation of the Building
                                    equipment or other improvements comprising
                                    part of the Property or equipment, except
                                    that conditions (not occasioned by
                                    construction defects) resulting from
                                    ordinary wear and tear will not be deemed
                                    defects for the purpose, of this category;
                                    the cost of repair or replacement for any
                                    item covered by a warranty;

                           8.       Casualty and Condemnation Costs. The cost of
                                    any repair made by Landlord because of the
                                    total or partial destruction of the Building
                                    or the condemnation of a portion of the
                                    Building or other improvements comprising
                                    part of the Property or equipment and
                                    payable by condemnation proceeds and/or
                                    insurance proceeds, and any amounts
                                    constituting the deductible portion of
                                    insurance.

                           9.       Additions. Except as permitted above, the
                                    cost of any additions, expansions or capital
                                    improvements or expenditures to the Building
                                    or the Property (other than the Building
                                    Expansion Space, as hereafter defined);

                           10.      Initial Construction Costs. The cost of
                                    tools and equipment used initially in the
                                    construction of the Building or other
                                    improvements comprising part of the
                                    Property; the cost of any "tap fees" or one
                                    time lump sum sewer or water connection fees
                                    for the Property unless due to service
                                    upgrades required by Tenant;

                           11.      Recordation and Transfer Fees. Any
                                    documentary and transfer taxes imposed in
                                    connection with the Lease or any other lease
                                    except as set forth herein;

                           12.      Landlord Compliance Costs. The cost of
                                    overtime or other expense to Landlord in
                                    curing its defaults or performing work
                                    expressly provided in the Lease to be borne
                                    at Landlord's expense; amounts paid by
                                    Landlord (including interest) on account of
                                    or to cure violations of or deviations from
                                    the requirements of statutes, laws,
                                    regulations, notices or ordinances on any
                                    part of the Property or Building and any
                                    costs or expenses resulting from Landlord's
                                    violation of any agreement to which it is a
                                    party; costs incurred to test, survey,
                                    cleanup, contain, abate, remove or otherwise
                                    remedy hazardous materials or wastes or
                                    asbestos-containing materials from the
                                    Property unless the wastes or
                                    asbestos-containing materials were in or on
                                    the Property due to Tenant's negligent or
                                    intentional acts or Tenant's failure to

                                      -8-

<PAGE>

                                    comply with its obligations set forth in
                                    this Lease; and any amounts constituting the
                                    deductible portion of insurance for
                                    liability;

                           13.      Bad Debt Costs. Any and all collection
                                    costs, including legal fees and bad debt
                                    losses or reserves except to the extent
                                    attributable to Tenant;

                           14.      Excessive Management Fees. Property
                                    management fees in excess of Five Percent
                                    (5%) of gross rentals generated by the
                                    Property.

                           15.      Inflated, Excessive and Inappropriate Costs.
                                    Any otherwise permissible fees or costs, to
                                    the extent the same are in excess of
                                    prevailing and competitive rates; except as
                                    otherwise provided for herein, expenses that
                                    under generally accepted accounting
                                    principles consistently applied would not be
                                    considered normal maintenance, repair,
                                    management or operating expenses of the
                                    Building; and

                           16.      Enforcement Costs. Landlord's costs to
                                    compel full performance under leases with
                                    tenants of the Property except to the extent
                                    attributable to Tenant.

                           17.      Reimbursed Items. Any cost that is
                                    reimbursed to Landlord by third parties.

                                    (c)     The term "Taxes" means any present
or future federal, state, municipal, local and/or any other taxes,
assessments, levies, benefit charges and/or other governmental and/or private
impositions (including any business park charges), imposed, levied, assessed
and/or attributable directly or indirectly to the Property and/or the Building
or upon the Rent due and payable under this Lease, whether now customary or
within the contemplation of Landlord and Tenant and whether extraordinary or
ordinary, general or special, foreseen or unforeseen, or similar or dissimilar
to any of the foregoing. The term "Taxes" does not include any inheritance,
estate, succession, income, profits or franchise tax, gift taxes, transfer
taxes, capital levies or similar taxes on Landlord's business. If, however, at
any time during the Lease Term the method of taxation prevailing on the
Commencement Date is altered or eliminated so that one or more of the items
listed in the first sentence of this subparagraph C.1(c) is replaced by a
levy, assessment or imposition, wholly or partly as a capital levy, or
otherwise, on the rents or income received from the Property and/or the
Building (provided the tax on such income is not a tax levied on taxable
income generally) wholly or partly in place of an imposition on, a substitute
for, or an increase of, taxes in the nature of real estate taxes issued
against the Property and/or the Building, the charge to Landlord resulting
from such altered or replacement method of taxation will be deemed to be
within the definition of "Taxes". All reasonable expenses incurred by Landlord
(including attorneys' fees and court costs) in contesting any increase in
Taxes or any increase in the assessment of the Property and/or the Building
will be included as an item of Taxes for the purpose of computing Additional
Rent due under this Lease. Landlord shall, at the request and sole cost and
expense of Tenant, cooperate in Tenant's application for real property tax
abatements or deferrals, including but not limited to those arising out of the

                                      -9-

<PAGE>

so-called "Miller Legislation". Any resulting tax decreases or credits
applicable to the Lease Term shall be passed solely to Tenant as a decrease or
credit to Tenant's obligations hereunder.

                                    (d)     The term  "Insurance"  means  the
cost of all insurance relating to the Property of whatsoever nature kept or
caused to be kept in force by Landlord to protect itself and/or its
mortgagee(s) against liability and casualty loss, which includes, but is not
limited to, coverage for physical damage to owned or leased property, loss of
rents insurance, primary and umbrella or excess liability insurance, boiler
and machinery insurance and workers compensation insurance. The term "Full
Insurable Value" shall mean actual replacement costs of the Building
(exclusive of the costs of excavation, foundations and footings below the
lowest basement floor), or such other amounts as may be required by Landlord's
lender.

                           2.       RENT ADJUSTMENT--COMMON AREA EXPENSES AND
TAXES. Tenant agrees to pay to Landlord, in each year of the Lease Term,
Tenant's Portion of Common Area Expenses and Taxes (collectively, the
"Expenses"). Until the actual amounts of such Expenses are determined by
Landlord, Tenant agrees to pay to Landlord, as Additional Rent, with and at
the same time as the monthly payments of Basic Annual Rent (provided, however,
that such payments shall commence on the Commencement Date whether or not the
Basic Annual Rent commences then), the following amounts:

                                    (a)     Five Thousand Three Hundred
Twenty-Six Dollars and Fifty Cents ($5,326.50) per month ($1.50 p.s.f.) as
one-twelfth of Tenant's estimated Portion of the Common Area Expenses; and

                                    (b)     Five Thousand Three Hundred
Twenty-Six Dollars and Fifty Cents ($5,326.50) per month ($1.50 p.s.f.) as
one-twelfth of Tenant's estimated Portion of Taxes.

                                    At any time during a Lease Year, Landlord
 may revise its estimate of Tenant's Portion of any such Expenses and adjust
Tenant's monthly installments to reflect the revised estimates. Landlord shall
give Tenant not less than thirty (30) days' prior written notice of the
revised estimates and the amount by which Tenant's monthly installments shall
be adjusted, and Tenant shall pay the adjusted installments with each payment
of the Rent, beginning with the first payment of the Basic Annual Rent to come
due after Tenant's receipt of such prior written notice.

                                    Landlord shall deliver to Tenant on or
before May 1 of each calendar year during the Lease Term and on May 1 of the
calendar year following the expiration or earlier termination of this Lease, a
statement for the immediately preceding calendar year (or portion thereof
applicable to the Lease Term) (the "Statement"), showing Tenant's Portion of
such costs. Tenant will pay Landlord, within sixty (60) days of the receipt of
the Statement, such amounts as may be necessary to adjust Tenant's payments of
its estimated Portion of the Expenses for such preceding period so that such
payments will equal the actual amount of Tenant's Portion of such Expenses for
such period. If the actual amount of Tenant's Portion of such costs for such
preceding period is less than the amounts paid by Tenant as installments of
its Portion of such costs, then Landlord will credit Tenant's account by the
amount of the excess or, if at the end of the Lease Term, refund to Tenant the
amount of the excess. Unless Tenant gives Landlord written notice of its
exception to any Statement within sixty (60) days after delivery thereof, the
same shall be conclusive and binding on Tenant; provided, however, that in the
event that Tenant shall give Landlord written notice

                                      -10-

<PAGE>

of its exception to such Statement within such sixty (60) day period, Tenant
shall nevertheless be obligated to pay the Additional Rent. At its sole cost
and expense and without unreasonable interference with Landlord's business
operations or waiving Tenant's obligation to pay the amount shown on such
Statement, Tenant shall have the right (but not more than once in any twelve
month period), upon at least ten (10) business days prior written notice given
to Landlord within sixty (60) days after its receipt of a Statement, to
examine the books, records and other papers of Landlord used to compute the
Expenses reflected on such Statement (the "Audit"). Any overpayment by Tenant
of Additional Rent for such period reflected by such examination shall be
credited against Tenant's obligation to pay Additional Rent, or if, at the end
of the Lease Term, refunded to Tenant within sixty (60) days of the end of the
Lease Term. In the event of any errors on the part of Landlord in excess of
five percent (5%) of Tenant's Portion for any calendar year, Landlord will
also reimburse Tenant for all reasonable costs incurred by Tenant with respect
to its Audit. Any such examination shall be conducted only during Landlord's
regular business hours, and all information examined shall be kept by Tenant
in the strictest confidence except to the extent necessary to enforce Tenant's
rights, if any hereunder, in a court of competent jurisdiction.

                                    Notwithstanding the foregoing, Landlord
and Tenant agree that with respect to those components of Common Area Expenses
that are within Landlord's reasonable control, Tenant's actual share of such
costs shall not increase each year by more than five percent (5%) of such
costs in the preceding year. Landlord and Tenant agree that those items listed
in subsections (b)(i), (iv), (vi), (viii) and (c) above are not within
Landlord's reasonable control and, therefore, not subject to such five percent
(5%) cap.

                                    Failure of Landlord to provide any
Statement within the time prescribed will not relieve Tenant of its
obligations under this Paragraph III.C.2. It is agreed that no Statement will
include a reassessment or recapture from any prior year's Expenses.

                           3.       SUMMARY OF PAYMENTS. The following is a
list of the various payments and installments of Basic Annual Rent and
Additional Rent under the Lease pursuant to this Section III as of the
Commencement Date. Some of these amounts will change during the Lease Term.

<TABLE>
<CAPTION>

                                                        Monthly                           Annual
                                                     Installments                       s.f. Amount
                                                     ------------                       -----------
<S>                                                  <C>                                <C>

Basic Annual Rent:
         (Months 1 - 12)                               $51,837.50                           $14.50

Common Area Expenses
         (estimate)                                    $ 5,362.50                           $ 1.50

Taxes    (estimate)                                    $ 5,362.50                           $ 1.50

TOTAL                                                  $62,562.50                           $17.50

</TABLE>

                           4.       UTILITIES. To the extent utilities for the
use of the Leased Premises by Tenant are not included within Common Area
Expenses, Tenant agrees to pay promptly to the appropriate supplier all such
charges for water, gas, steam, electricity or other power source, telephone
and all other utility and communication services used and/or supplied by
Tenant in connection with Tenant's use of the Leased Premises.

                                      -11-
<PAGE>

         IV.      CONDITIONS OF TENANT'S OCCUPANCY AND POSSESSION

                  A.       USE RESTRICTIONS AND RULES. Tenant agrees to use
the Leased Premises only for general office, research and development, light
manufacturing and bioprocessing, laboratory, warehouse, animal research and
storage, and storage purposes, and for no other purpose. In addition, Tenant
agrees to be bound by all laws, requirements, rules, orders, ordinances,
zoning and restrictive covenants applicable to the Property or Tenant's use of
the Leased Premises, whether in force on or after the Commencement Date, and
by the Rules and Regulations as announced by Landlord from time to time,
including those set forth in EXHIBIT F (collectively, the "Restrictions")
provided that in respect to any future modification or addition to the Rules
and Regulations, Tenant shall not be required to comply with any Rule or
Regulation to the extent it conflicts with this Lease or either increases
Tenant's obligations or decreases Tenant's rights hereunder in a material and
adverse manner or are not uniformly enforced by Landlord. Landlord shall
notify Tenant in writing of all future additional or modified Rules and
Regulations from time to time established.

                  Landlord will indemnify Tenant and hold Tenant harmless from
and against any losses, costs, damages or claims of whatever nature arising
out of or in connection with the failure of the Base Building to comply with
ADA requirements and applicable life safety codes as of the date hereof.
Notwithstanding the preceding sentence, Tenant shall pay the cost of any
improvements to the Leased Premises required as a result of Tenant's
particular, specialized use of the Leased Premises. Tenant shall indemnify
Landlord and hold Landlord harmless from and against any losses, costs,
damages or claims of whatever nature arising out of or in connection with the
failure of the Leased Premises, as finished in accordance with the TI Plans
and Specifications, to comply with ADA requirements and applicable life safety
codes at any time during the Lease Term.

                  B.       IMPROVEMENTS BY TENANT. After completion of the
work to be performed by Landlord and Landlord's contractor in accordance with
the Plans and Specifications listed in EXHIBIT C, Tenant will not make any
further improvements, alterations, installations or additions to the Leased
Premises unless (1) it receives Landlord's prior written consent, which will
not be unreasonably withheld; (2) the work is performed only by licensed and
bonded contractors approved in advance by Landlord; (3) the work is carried
out pursuant to properly documented drawings approved in advance by Landlord
and pursuant to all necessary permits or governmental and/or other approvals,
the responsibility and cost of obtaining which will be borne solely by Tenant;
(4) Tenant pays all costs of such work; (5) the quiet enjoyment of other
tenants in the Building is not disturbed; and (6) work does not materially and
adversely impact the aesthetics or functional integrity of the Building in
Landlord's reasonable opinion or void or diminish the roof warranty of the
Building. If Tenant elects to use a contractor other than Landlord or its
representative, then the work performed by such contractor will be under the
general supervision of Landlord, and Tenant will pay Landlord a reasonable
supervisory fee. Notwithstanding the foregoing, Landlord's consent shall not
be required for any alterations, installations, additions and/or improvements
to the Leased Premises, including, but not limited to, the installation of any
fixtures, amenities, equipment, appliances or other apparatus, the cost of
which is less than $50,000 and/or which is of a non-structural nature and/or
which does not involve the mechanical, electrical, plumbing and/or HVAC System
(collectively, the "Work"); provided, however, Tenant complies with all other
provisions herein with respect to such Work. All such Work shall

                                      -12-

<PAGE>

be done at Tenant's sole cost and expense and at such times and in such manner
as Landlord may from time to time designate. All such Work shall be done under
the general supervision of Landlord to assure standard quality improvements on
the Property for which Landlord shall be reimbursed for all of Landlord's
reasonable out-of-pocket expenses with respect to Landlord's review and
supervision of the Work.

                           With the exception of movable trade fixtures and
furniture, all alterations, additions and improvements made by Tenant are
hereby deemed the property of Landlord and will remain a part of the Leased
Premises upon this Lease's termination. Landlord, however, may request in
writing that Tenant remove any or all of them no later than the termination
date of this Lease. In response to Landlord's request, Tenant promptly will
perform such removal and restore the Leased Premises to their original
condition, all at Tenant's sole cost.

                           Notwithstanding the above,  Landlord acknowledges
that certain Tenant Improvements are highly specialized and essential
("Specialized Tenant Improvements") for Tenant's specific use of the Leased
Premises. Therefore, those items set forth in EXHIBIT G may be
removed by Tenant upon this Lease's termination, and Tenant shall promptly
restore the Leased Premises to their original condition following such
removal, and substitute mechanical and operating systems as Landlord
determines necessary, all at Tenant's sole cost and expense.

                  C.       MAINTENANCE.

                           1.       Tenant will, at its sole cost,  keep the
Leased Premises in good condition and repair, normal wear and tear, insured
casualty and condemnation excepted. Tenant's responsibility under this
Paragraph IV.C.1. will include, but will not be limited to, maintenance and
repair of all interior and exterior windows and doors, hardware, locks, light
fixtures, pipes, plumbing, and electrical connections.

                           2.       Landlord, at its sole cost and expense but
which shall be reimbursed to Landlord to the extent part of Common Area
Expenses, shall maintain the Base Building, the structural exterior walls
(excluding the windows and doors), downspouts and roof of the Leased Premises,
as long as such maintenance is not required because of the acts or omissions
of Tenant or its representatives, agents, employees, or visitors, in which
event such maintenance shall be done by Landlord at Tenant's sole cost.

                           3.       Tenant will not commit or suffer any waste
of the Leased Premises and will assume responsibility for all maintenance and
repair, regardless of the nature, pertaining to the heating and/or air
conditioning equipment. Tenant will secure and maintain during the Lease Term,
a full service contract on such mechanical equipment with a company reasonably
acceptable to Landlord and providing at least the services outlined on the
attached Exhibit H. Tenant must deliver a copy of such service contract to
Landlord upon the commencement of the Lease Term and whenever a change of
company or a change in such contract occurs. At the expiration of the Lease
Term, Tenant must also deliver to Landlord a certification from the company
regularly maintaining the mechanical systems in the Leased Premises, which
certification must be based on an inspection conducted within thirty (30) days
of the termination date of the Lease and which must state that all such
systems are in good operating order and be in substantially the form attached
as EXHIBIT I. Landlord or Landlord's representatives may enter the Leased
Premises at any reasonable time and in the presence of an escort designated by
Tenant to verify Tenant's compliance with this Lease, provided that

                                      -13-

<PAGE>

notwithstanding anything to the contrary in this Lease, except in case of an
emergency, Landlord shall provide notice of not less than twenty-four (24)
hours, which may be verbal, prior to entering the Leased Premises under any
provision of this Lease affording any rights to Landlord of repair, entry or
inspection. In the event Tenant fails to maintain the mechanical equipment as
provided in this Paragraph IV.C.3., Tenant will be liable to Landlord for any
costs incurred by Landlord in maintaining or repairing such mechanical
equipment.

                           4.       At the expiration or termination of the
Lease, Tenant will leave the Leased Premises clean and at least in the same
good condition (reasonable wear and tear excepted) as when the Lease Term
began. Tenant will remove all of its property and possessions from the Leased
Premises except to the extent provided by Paragraph IV.B. above. Any items of
Tenant's personalty remaining in the Leased Premises after the termination of
the Lease shall be deemed abandoned by Tenant and become the sole property of
Landlord. Notwithstanding the foregoing, any costs incurred by Landlord in
storing and/or disposing of such abandoned property shall remain the sole
obligation of Tenant, which obligation shall survive the termination of this
Lease.

                  D.       CONDUCT ON LEASED PREMISES. Tenant will neither do,
nor permit anyone else to do anything on the Leased Premises which might or
would (1) interfere with the good order of the Property; (2) interfere with
the rights of other tenants of the Property; (3) increase any insurance rates
charged Landlord with respect to the Property; or (4) conflict with or
invalidate any insurance policy maintained by Landlord for the Property. If
the insurance premiums of Landlord are increased due to Tenant's use or
occupancy of the Leased Premises, then the amount of such increase will be
paid by Tenant to Landlord as Additional Rent as it becomes due, and Landlord
will have the same right to collect such amount as Landlord has under this
Lease to collect Additional Rent.

                  E.       INSURANCE. Tenant will purchase at its sole cost,
from an insurance company licensed to do business in the State of Maryland and
approved by Landlord, a policy of public liability insurance covering the
Leased Premises and the business conducted by Tenant there. The policy will be
kept in force during the entire Lease Term. The policy will have minimum
limits of liability of (1) $1,000,000 in respect to any one occurrence and (2)
$2,000,000 in respect to the general aggregate limit of liability. The policy
must name Landlord and Manekin, LLC as additional insureds, and must contain
an agreement by the insurer not to cancel or change the insurance without
first giving Landlord thirty (30) days' prior written notice. Tenant will
furnish Landlord with a certificate of insurance no later than the
Commencement Date and on the date of each policy renewal.

                  At all times throughout the Lease Term, Landlord will
maintain (a) fire, casualty and extended coverage insurance covering the
Building and all improvements on the Property in an amount equal to the Full
Insurable Value thereof and sufficient to prevent Landlord from being a
co-insurer under its policies of insurance, and (b) public liability and
property damage insurance in an amount equal to that required to be maintained
by Tenant.

                           Landlord and Tenant hereby  mutually  waive all
claims for recovery from the other for any loss or damage to any of Landlord's
or Tenant's property insured under valid and collectible insurance policies to
the extent of any recovery for loss insured under those policies. The parties
agree that a mutual subrogation clause shall be included in each insurance
policy setting forth that the insurance shall not be invalidated

                                      -14-

<PAGE>

in the event that the insured waives in writing, before any loss, any or all
right of recovery against the other party for any insured loss.

                  F.       LIENS. Except as provided in paragraph X.P. herein,
Tenant will not do anything, or permit anything to be done, which subjects all
or any part of the Leased Premises or Tenant's interest in it to any lien or
encumbrance. This includes, but is not limited to, mechanics' or materialmen's
liens. If any such lien is filed purporting to be for work or material
furnished to Tenant, then Tenant must have such lien discharged or bonded
within ten (10) days of notice to Tenant of its filing.

                  G.       ENVIRONMENTAL ASSURANCES.

                           1.       REPRESENTATIONS. Tenant represents and
warrants to Landlord that, to the best of Tenant's knowledge, neither Tenant
nor any affiliate of Tenant has Generated (as defined below) or is, as of the
date of execution of this Lease, Generating Hazardous Substances (as defined
below) at, to or from the Leased Premises.

                           With regard to the Leased Premises,  the Building,
the Property and any property and equipment relating thereto to which Landlord
has title or sole and absolute control (the "Total Premises"), Landlord
represents and warrants to Tenant that, to Landlord's knowledge and without
independent verification, (a) as of the Commencement Date of the Lease, no
Hazardous Substance, as hereafter defined, have been manufactured, refined,
stored, disposed of, produced or processed on or in any part of the Total
Premises and the Total Premises contains no underground storage tanks; (b) the
Landlord has not been named as a party in any proceeding or lawsuit for
violation of federal, state or local environmental laws; and (c) no portion of
the Total Premises is currently, or has been, the subject of any investigation
for alleged federal, state, county or municipal environmental, pollution,
health, safety, fire or building code violations.

                           2.       COVENANTS. Tenant covenants with Landlord:

                                    (a)     that it shall not  Generate
Hazardous Substances at, to or from the Leased Premises unless the same is
specifically approved in advance by Landlord in writing. Landlord consents to
Tenant's Generation of those "Hazardous Substances" listed on Exhibit J
attached hereto and made a part hereof which are normally used in Tenant's
business so long as Tenant Generates such substances in accordance with all
applicable legal requirements, the Restrictions and this Lease and further in
accordance with any manufacturers' labeling requirements, and provided further
Tenant, at its sole expense, obtains all necessary consents and permits for
such Generation and Tenant provides Landlord with financial assurances (e.g.,
a liability insurance policy or a bond for Landlord's (and its lender's)
benefit) with regard to such Generation in such form and amounts as may be
reasonably requested by Landlord or by Landlord's lender and consistent with
commercially sound custom and practice for similar tenants in the marketplace;

                                    (b)     to comply with all obligations
imposed by applicable law, and regulations promulgated thereunder, and all
other restrictions and regulations upon the Generation of Hazardous Substances
(whether or not at, to or from the Leased Premises);

                                    (c)     to deliver  promptly to Landlord
true and complete copies of all notices received by Tenant from any

                                      -15-

<PAGE>

governmental authority with respect to the Generation by Tenant of Hazardous
Substances to or from the Leased Premises;

                                    (d)     to complete fully, truthfully,
and promptly any questionnaires sent by Landlord with respect to Tenant's use
of the Leased Premises and Generation of Hazardous Substances;

                                    (e)     to permit entry onto the Leased
Premises by Landlord or Landlord's representatives upon prior notice (which
may be written or verbal) except in cases of emergency where no notice is
required at any reasonable time to verify and monitor Tenant's compliance with
its representations, warranties and covenants set forth in this Paragraph.
Landlord or Landlord's representative must be accompanied by a representative
of Tenant when entering the Leased Premises, except in cases of emergency. In
the event of an emergency, Landlord shall use its best efforts to contact
Tenant before entering the Leased Premises without being accompanied by a
representative of Tenant; and

                                    (f)     to pay to Landlord, as
Additional Rent, the costs incurred by Landlord hereunder, including the
reasonable costs of such monitoring and verification.

                                    (g)     to  furnish to Landlord, at
the expiration of the Lease Term or at the sooner termination of the Lease
Term as herein provided, a certification in form and content acceptable to
Landlord from an environmental audit company acceptable to Landlord to the
effect that, based upon an inspection conducted by such environmental audit
company not more than thirty (30) days prior to the expiration or termination
of the Lease Term, the Leased Premises are free from Hazardous Substances.

                           3.       INDEMNIFICATION.

                           (a)      INDEMNIFICATION BY TENANT. Tenant agrees
to indemnify and defend Landlord and its managers and agents (with legal
counsel reasonably acceptable to Landlord) from and against any costs, fees or
expenses (including, without limitation, environmental assessment,
investigation and environmental remediation expenses, third party claims and
environmental impairment expenses and reasonable attorneys' fees and expenses)
incurred by Landlord, or its managers or agents, as the case may be, in
connection with Tenant's Generation of Hazardous Substances at, to or from the
Leased Premises or in connection with Tenant's failure to comply with its
representations, warranties and covenants set forth in this Paragraph. This
indemnification by Tenant shall remain in effect after the termination or
expiration of this Lease.

                           (b)      INDEMNIFICATION BY LANDLORD. Landlord
agrees to indemnify and defend Tenant and its officers, directors and agents
(with legal counsel reasonably acceptable to Tenant) from and against any
costs, fees or expenses (including, without limitation, environmental
assessment, investigation and environmental remediation expenses, third party
claims and environmental impairment expenses and reasonable attorneys' fees
and expenses) incurred by Tenant in connection with Landlord's Generation of
Hazardous Substances at, to or from the Leased Premises. This indemnification
by Landlord shall remain in effect after the termination or expiration of this
Lease.

                           4.       DEFINITIONS. The term "Hazardous
Substance" means (a) any "hazardous waste" as defined by the Resource
Conservation and Recovery Act of 1976 (42 U.S.C. section 6901 ET SEQ.), as
amended from time to time, and regulations promulgated

                                      -16-

<PAGE>

thereunder; (b) any "hazardous substance" as defined by the Comprehensive
Environmental Response, Compensation and Liability Act of 1980 (42 U.S.C.
section 9601 ET SEQ.), as amended from time to time, and regulations
promulgated thereunder; (c) any "oil," as defined by the Maryland Environment
Code Ann. section 4-401(g) as amended from time to time, and regulations
promulgated thereunder; (d) any "controlled hazardous substance" or "hazardous
substance" as defined by the Maryland Environment Code Ann., section 7-201, as
amended from time to time, and regulations promulgated thereunder; (e) any
"infectious waste" as defined by the Maryland Environment Code Ann. section
9-227, as amended from time to time, and regulations promulgated thereunder;
(f) any substance the presence of which on the Property is prohibited,
regulated or restricted by any local law or regulation or any other law or
regulation similar to those set forth in this definition; and (g) any other
substance which by law or regulation requires special handling in its
Generation. The term "To Generate" means to use, collect, generate, store,
transport, treat or dispose of.

                  H.       SIGNS. Tenant shall have the right, at its sole
cost and expense, to erect an identification sign on the exterior of the
Building, subject, however, to Tenant's obtaining the prior written approval
of such signs from Landlord and all applicable authorities including, but not
limited to, the City of Gaithersburg and Montgomery County. Landlord shall not
unreasonably withhold, condition or delay its consent to such signs provided
same are reasonably similar to other corporate identification signs within
Bennington Corporate Center and in compliance with the restrictive covenants
applicable to the Property. Such signs shall be installed by a reputable
contractor reasonably acceptable to Landlord. Tenant shall hold Landlord
harmless from any damage caused to the Building as a result of the
installation of such signs. Upon termination of the Lease, it shall be
Tenant's obligation, at its sole expense, to remove such signs and to restore
the exterior face of the Building to its condition prior to erecting such
signs, normal wear and tear excepted.

         V.       LANDLORD'S RIGHTS AND RESPONSIBILITIES

                  A.       ACCESS. Landlord or its authorized agent or
representative (E.G., a mortgagee, deed of trust holder, etc.) will have the
right to enter and examine the Leased Premises at any reasonable hour upon not
less than twenty-four (24) hours' prior notice (which may be verbal or
written), or at any time (and without notice) in the event of an emergency. In
addition, Landlord and/or an authorized representative of Landlord or any
mortgagee or deed of trust holder must be accompanied by a representative of
Tenant when entering the Leased Premises, except in cases of emergency. In the
event of an emergency, Landlord shall use its best efforts to contact Tenant
before entering the Leased Premises without being accompanied by a
representative of Tenant.

                  B.       BUILDING REPAIRS. Landlord shall repair and
maintain, or cause to be repaired and maintained, in a first class manner as
comparable to buildings in the same geographical area as the Building, the
structural components of the Building as set forth in IV C.2. above. Landlord
may, but will not be obligated to, make such repairs, alterations or
improvements as it or its authorized representatives deem necessary for the
safety or preservation of the Building or for any other reasonable purpose.
The Rent will not abate while Landlord is exercising any of its rights under
this Paragraph V.B. The immediately preceding sentence shall not be construed
as vitiating any abatement provisions herein, including, without limitation,
abatement for

                                      -17-

<PAGE>

certain casualty events, condemnation, negligence or willful misconduct.

                  C.       PERFORMANCE OF TENANT'S RESPONSIBILITIES BY
LANDLORD. If Tenant fails to perform or otherwise comply with any covenant or
term in this Lease after any applicable cure periods, then Landlord may
perform the obligation for Tenant at any time after ten (10) days following
Landlord's giving Tenant written notice of such failure. Any performance by
Landlord under this Paragraph V.C. will be solely at the option of Landlord,
and Landlord's reasonable cost will be charged to Tenant. Tenant will pay
Landlord all such costs (plus interest at a rate of two (2) percentage points
above the prime rate as announced by Citibank, N.A. from time to time)
incurred by Landlord in performing Tenant's obligations. Such payment by
Tenant will be made within thirty (30) days of Landlord's delivery to Tenant
of a statement for such costs with reasonable supporting documentation.
Landlord's rights provided in this Paragraph V.C. are in addition to any other
right Landlord has under this Lease.

                  D.       LOSS, DAMAGE, INJURY. Landlord will not be liable
or responsible to Tenant, or to any other person or entity, for any damage,
injury, destruction or death due to or arising out of any cause whatsoever
other than Landlord's or its agents, employees and contractors willful
misconduct or negligence. This limitation of liability will remain in effect
after the expiration or termination of this Lease.

                  E.       MUTUAL INDEMNITY. Landlord and Tenant agree that
each shall indemnify and hold harmless the other, and Landlord's agents and
managers, for all losses, damages, liabilities, costs, payments, expenses and
fines incurred by one party (the "Indemnitee") as a result of any claim or
action (whether or not such claim or action proceeds to final judgment)
brought or threatened for any of the following acts or omissions of the other
party (the "Indemnitor"), and/or of the Indemnitor's servants, employees,
agents, licensees or invitees: (1) any breach, violation and/or nonperformance
of any covenant or provision of this Lease applicable to the Indemnitor and/or
(2) negligence or any willful misconduct of the Indemnitor. This
indemnification shall remain in effect after the termination or expiration of
this Lease.

         VI.      DAMAGE AND DESTRUCTION

                  In the event of partial or total damage or destruction to
the Leased Premises by fire, other casualty, or any other cause whatsoever,
then Tenant shall give immediate notice thereof to Landlord and: (a) this
Lease shall continue in full force and effect unless terminated pursuant to
the provisions below and (b) Landlord, to the extent that insurance proceeds,
including deductibles, respecting such damage or destruction are subject to
being utilized for and, in fact may be utilized by Landlord therefor, shall
thereupon cause such damage or destruction to be repaired with reasonable
speed at the expense of Landlord, due allowance being made for reasonable
delay which may arise by reason of adjustment of loss under insurance policies
on the part of Landlord and/or Tenant, and for reasonable delay on account of
labor disputes resulting in work stoppages beyond Landlord's control or any
other cause beyond Landlord's control, and to the extent that the Leased
Premises are rendered untenantable, the Rent shall proportionately abate.

                  Landlord shall have no obligation to rebuild the Leased
Premises if the reasonably estimated cost of repair and reconstruction exceeds
fifty percent (50%) of the Full Insurable Value including any and all
deductibles, of the Leased Premises

                                      -18-

<PAGE>

unless: (i) on the date of such destruction there shall be four (4) or more
years remaining in the Lease Term or (ii) within thirty (30) days of the date
of such destruction, Tenant, at its option, shall enter into an agreement with
Landlord to extend the Lease Term for a period of at least four (4) years from
the date of such destruction. If Tenant so elects to extend the Lease Term,
Landlord covenants to promptly execute and deliver to Tenant a written
agreement evidencing such extension. In the event Tenant elects not to so
extend this Lease, Landlord shall have the right to either (i) waive the
extension requirement and rebuild the Leased Premises as set forth above, or
(ii) terminate this Lease by giving notice of such election to Tenant, in
which event Landlord shall be entitled to retain all insurance proceeds.

                  Notwithstanding the provisions of this Section VI, within
sixty (60) days after the date of material destruction of the Leased Premises,
Landlord shall obtain a certificate from Landlord's architect of an estimate
of the time which will be required to repair the Leased Premises. Landlord
shall promptly communicate said estimate to Tenant. In the event that said
estimate of time exceeds two hundred seventy (270) days from the date of such
destruction, then Tenant shall have the right, within ten (10) days after
receipt of said estimate, to terminate this Lease without any further
liability or obligation on the part of the parties hereto for obligations
thereafter accruing, provided that Tenant shall give written notice to
Landlord within said ten (10) days and shall not be in breach or default of
any covenant or condition by which Tenant is obligated under this Lease. In
the event Landlord commences repairs hereunder but fails, for reasons within
its reasonable control, to complete such repairs within two hundred seventy
(270) days from the date of such destruction, then Tenant shall have the
right, by providing written notice to Landlord on or before the 275th day
following the date of such destruction, to terminate this Lease without any
further liability or obligation on the part of the parties hereto thereafter
accruing.

         VII.     CONDEMNATION

                  Landlord represents that, to its actual knowledge, there is
no pending or threatened taking, condemnation, eminent domain or similar
proceeding relating to the Property, the Building or the Leased Premises. This
Lease will terminate immediately upon: (i) a taking or condemnation of the
entire Leased Premises for public purposes; (ii) a partial taking which
prevents the Tenant, from being reasonably able to use the remainder of the
Leased Premises for the purposes intended by this Lease; or (iii) upon
Landlord's conveyance or lease of the Building to any condemning authority in
settlement of a threat of condemnation or taking. The Rent shall be adjusted
and abated to the date of termination due to such taking, leasing or
conveyance.

                  In the event of a partial taking for which this Lease is not
terminated, the Rent will abate in an amount which, in Landlord's judgment, is
proportionate to the area and value of the Leased Premises so taken, leased or
conveyed. Tenant, however, will not have any claim against Landlord, nor any
claim for any award from the condemning authority arising out of any such
taking, lease, conveyance or condemnation action nor in any way arising out of
its leasehold interest in the Leased Premises, but will have the right to
pursue a separate claim against the condemning authority for its own loss of
business, moving expenses and those specialized Tenant Improvements listed on
Exhibit G.

                                      -19-
<PAGE>

VIII.             HOLDING OVER

                  This Lease is for a specific Lease Term. If Tenant,  without
 Landlord's specific written consent, continues its possession of the Leased
Premises after the termination date of this Lease, then all of the following
conditions will apply: (i) Tenant will occupy the Leased Premises as a month
to month tenant on the terms of this Lease, except that its occupancy will be
at two times the Rent payable during the last year of the Lease Term and will
be subject to termination on thirty (30) days' prior written notice from
Landlord; (ii) Tenant will be liable to Landlord for any damages suffered by
Landlord due to such holding over, including the loss of financial benefits
from another potential tenant occupying the Leased Premises; and (iii) Tenant
will indemnify Landlord for any losses or expenses (including reasonable
attorneys' fees) incurred by Landlord in connection with claims or litigation
(E.G., due to a delayed commencement date for a new tenant) arising because
Tenant held over.

IX.      DEFAULT

                  A.       EVENTS OF DEFAULT. Each of the following
constitutes a material breach and a default by Tenant under this Lease (an
"Event of Default"), entitling Landlord to all remedies set forth below or
existing at law or in equity:

                           1.       Any of the following legal actions filed
by or against Tenant and not bonded or discharged within forty (45) days of
the date of filing: (a) a petition under the Federal Bankruptcy Code (as now
or later amended or supplemented) or for reorganization, arrangement or other
rehabilitation within the meaning of the Federal Bankruptcy Code; or (b) any
action or proceeding for the dissolution or liquidation of Tenant, or for the
appointment of a receiver or trustee of the property of Tenant.

                           2.       Tenant's suspension of business;

                           3.       Tenant's making an assignment for the
benefit of creditors.

                           4.       The filing of a tax lien against any
property of Tenant; provided, however the filing of such lien shall not be
deemed an event of default so long as Tenant, in good faith, takes all
necessary steps to contest such lien including bonding such lien within thirty
(30) days after the date of its filing.

                           5.       Tenant's causing or permitting the Leased
Premises to be vacant, or its abandoning or ceasing to do business (for the
purpose specified in this Lease) actively in the Leased Premises for a period
in excess of ten (10) days; provided, however, that Tenant's ceasing to do
business in the Leased Premises shall not be deemed an event of default so
long as Tenant continues to pay all sums payable by Tenant hereunder when due
and continues to perform all other obligations of Tenant hereunder when the
same are required to be performed.

                           6.       Tenant's failure to pay Rent, Tenant's
Minimum Contribution and/or all or any part of any other sum (including late
charges) required by this Lease within ten (10) days after Landlord has given
written notice that such payment is due, provided however, that no notice
shall be required to be given to Tenant, and Tenant shall be in immediate
default, if Landlord has given such notice to Tenant one (1) time in the
preceding twelve (12) months.

                                      -20-

<PAGE>

                           7.       Tenant's failure to perform any other
term, covenant or condition required by this Lease and failure to cure within
ten (10) days after Landlord has given Tenant written notice of such failure,
provided however, if the nature of the violation or failure is such that more
than ten (10) days are reasonably required for its cure, then Tenant shall not
be in default if it begins such cure within the ten (10) day period and
thereafter diligently prosecutes such cure to completion.

                  B.       EFFECT OF DEFAULT. Landlord's rights and remedies
under this Lease will be cumulative. None will exclude any other right or
remedy available at any time under this Lease or under any law.

                           Even if Landlord does not seek Tenant's  strict
performance of any provision of this Lease, or does not exercise any right it
has, Landlord will not be construed as waiving its right to strictly enforce
Tenant's performance in the future. Similarly, if Landlord receives Rent with
knowledge of an Event of Default, then Landlord will not be construed as
having waived such Event of Default.

                           There will be no waiver by  Landlord of any Lease
provision unless expressed in writing and signed by Landlord.

                  C.       TERMINATION OF LEASE AND POSSESSION OF LEASED
PREMISES. Upon any Event of Default set forth in Paragraph IX.A. above,
Landlord may then, or at any later time, without further notice to Tenant,
terminate this Lease and Tenant's right to possess the Leased Premises.
Landlord may then (with or without formal court action) take possession of the
Leased Premises and remove Tenant or any other occupant, and any property,
without relinquishing any other rights Landlord may have against Tenant.

                  D.       DAMAGES. In the event of any Event of Default,
Landlord will be entitled to receive from Tenant as damages, upon demand, all
expenses which Landlord incurs as a result of such Event of Default. These
damages include, but are not limited to, any unpaid sums of Tenant's Minimum
Contribution, the expenses (such as real estate brokerage commissions and
retrofit costs) of rerenting the Leased Premises, together with court costs
and actual attorneys' fees (and their actual expenses) incurred at the
standard hourly rates for such attorneys (but in no event will such fees and
expenses be less than fifteen percent (15%) of all of Landlord's expenses and
damages relating to such breach). In addition to the damages set forth in the
preceding sentences of this Paragraph IX.D., if Landlord terminates this Lease
as set forth in Paragraph IX.C. above, Landlord will also be entitled to
either:

                           1.       Liquidated  damages equal to the net
present value of the aggregate amount of Basic Annual Rent and Additional Rent
(computed on the basis of the Additional Rent due during the preceding 12
months or, if the Lease Term has been less than a total of 12 months, an
annualized amount) due pursuant to this Lease for the unexpired portion of the
Lease Term from the date of termination. The amount of such aggregate Rent
will be discounted at the discount rate of the Federal Reserve Bank in
Washington, D.C. on the date of the computation; or

                           2.       Damages for each month of the unexpired
portion of the Lease Term from the date of termination equal to the sum of (a)
the aggregate expenses (other than Additional Rent) paid by Landlord for items
which this Lease requires Tenant to pay for each applicable month; PLUS (b)
the amount of the installment of Basic Annual Rent which would have been
payable by Tenant if this Lease had not been terminated; PLUS (c) the monthly
average

                                      -21-

<PAGE>

of Additional Rent paid in the Lease Year (or an annualized portion if the
Lease Term has been less than a total of 12 months to the date of termination)
immediately preceding the default, MINUS the rents, if any, collected by
Landlord for each such month through rerenting or through permitted subleases
of the Leased Premises. The damages under this subparagraph D.2. will be due
in monthly installments, in advance, on the first day of each calendar month
following such termination and will continue until the originally intended
expiration of the Lease Term. Landlord's action to collect, or its collection
of any damages for one month will not prejudice its rights to bring actions to
collect damages for subsequent months.

                           An acceptance of surrender of the Leased  Premises
must be in writing signed by Landlord. Tenant's liability under this Lease
will not be terminated by the execution of a lease with a new tenant for the
Leased Premises. Landlord may bring separate actions each month to recover
damages then due without waiting until the end of the Lease Term to compute
the aggregate damages.

                  E.       LANDLORD'S DEFAULT. In the event of Landlord's
failure to perform any obligation on its part to perform hereunder, in
addition to all other remedies available at law, Tenant shall have the right
after providing thirty (30) days written notice to Landlord of such default
(which period may be extended for whatever period of time is reasonably
required if such default cannot be reasonably cured with the exercise of
diligence within thirty days so long as Landlord commences such cure within
said thirty day period and thereafter diligently prosecutes such cure until
completion), to cure such default by Landlord in which event Landlord shall be
liable to Tenant for all reasonable costs and expenses incurred by Tenant in
curing such default; provided, however, in no event shall Tenant be entitled
to deduct the costs and expenses of curing such default from any amounts
payable by Tenant pursuant to the terms of the Lease, including all Basic
Annual Rent and Additional Rent.

                  F.       MITIGATION. Notwithstanding anything herein to the
contrary, upon the occurrence of any Event of Default that is not cured within
any applicable grace period, Landlord shall use its reasonable efforts to
mitigate its damages. If all amounts required to be paid by Tenant under this
Lease as damages and liquidated damages are actually paid to and collected by
Landlord, then any rent collected by Landlord with regard to the Leased
Premises from a subsequent tenant and attributable to the period for which
Tenant has paid liquidated damages, up to a maximum amount equal to the amount
of rental paid by Tenant as liquidated damages for such period, shall be
rebated to Tenant as and when such amounts are actually collected by Landlord.

X.       LEGAL AND GENERAL PROVISIONS

                  A.       ASSIGNMENT/SUBLETTING. No Assignment (as
hereinafter defined) of this Lease is permitted without the prior written
consent of Landlord. The granting or withholding of such consent will be given
solely within the discretion of Landlord. Notwithstanding the foregoing,
Landlord's consent to sublease all or any parts of the Leased Premises shall
not be unreasonably withheld, delayed or conditioned so long as the proposed
sublessee is no less creditworthy than Tenant as of the date thereof or as of
the Commencement Date of the Lease, whichever is greater, and the proposed use
is acceptable to Landlord, in each instance as determined by Landlord in its
sole, but reasonable, discretion.

                           The  foregoing  restriction  will  include,  but
not be limited to, the following (all of which will be deemed to be an
"Assignment"): (1) any assignment of this Lease or a subletting

                                      -22-

<PAGE>

of the Leased Premises; (2) any permission to a third party to use all or part
of the Leased Premises; (3) any mortgage or other encumbrance of this Lease or
of the Leased Premises; (4) the appointment of a receiver or trustee of any of
the Tenant's property; (5) any assignment or sale in bankruptcy or insolvency;
and (6) the transfer of majority control of Tenant by any means, including
operation of law, to parties other than those maintaining majority control on
the date on which the last party executes this Lease other than through a
public issuance of securities.

                           Notwithstanding the foregoing, so long as Landlord
receives prior written notice of such Assignment and Tenant remains primarily
liable for all of the terms of this Lease, Tenant may assign all or part of
this Lease, or sublease all or part of the Leased Premises without the consent
of Landlord, to:

                           (a)      any corporation that has the power to
direct Tenant's management and operations, or any corporation whose management
and operations are controlled by Tenant; or

                           (b)      any corporation, a majority of whose
voting stock is owned by Tenant; or

                           (c)      any corporation in which or with which
Tenant, its corporate successors or assigns, is merged or consolidated in
accordance with applicable statutory provisions for merger or consolidation of
corporations, so long as the liabilities of the corporations participating in
such merger or consolidation are assumed by the corporation surviving such
merger or created by such consolidation.

                           Even if Landlord consents to an Assignment, Tenant
will remain primarily liable under this Lease. Also, Tenant will bear all
reasonable legal costs incurred by Landlord in connection with Landlord's
review of documents concerning an Assignment, whether or not Landlord consents
to it and whether or not Landlord's consent is required. Landlord's consent to
a specific Assignment does not waive Landlord's right to withhold consent to
any future or additional Assignment. Tenant will give Landlord notice of its
intention to make an Assignment at least thirty (30) days prior to such
Assignment, which notice will contain such details as Landlord may reasonably
request.

                           If the amount of rent and other sums received by
Tenant under any Assignment is more than the Rent due from Tenant under this
Lease, then Tenant will pay fifty percent (50%) of the excess to Landlord on a
monthly basis and promptly upon Tenant's receipt of such excess amounts.

                           If, without Landlord's  consent,  this Lease is
Assigned, or if the Leased Premises are occupied or used by any party other
than Tenant, then all resulting expenses (including reasonable attorneys'
fees) incurred by Landlord will be immediately due and payable by Tenant upon
receipt of an invoice. Following an Event of Default, Landlord may collect
rent from the assignee, substenant, occupant or user (the "Assignee") of the
Leased Premises and apply it towards the Rent due under this Lease. Such
collection will not be deemed an acceptance of the Assignee as tenant, will
not waive or prejudice Landlord's right to initiate legal action against
Tenant to enforce Tenant's fulfillment of its obligations under this Lease and
will not release Tenant from such obligations.

                  B.       ESTOPPEL CERTIFICATES. At any time during the Lease
Term, and after ten (10) business days' prior written notice from Landlord,
Tenant will deliver to Landlord a properly executed

                                      -23-

<PAGE>

and acknowledged document, generally known as an estoppel certificate. Tenant
will certify in the estoppel certificate to the extent correct and to the
knowledge of Tenant, among other matters, that: (1) this Lease is in full
force and effect and if modified, the extent to which it is modified; (2) the
dates to which the Rent and other payments have been made; (3) to the best of
its knowledge, either Landlord has not breached this Lease or, if Landlord has
breached this Lease, the nature of the breach and (4) any other matter
reasonably requested by Landlord or its lenders. This estoppel certificate may
be relied upon by Landlord, its lenders and any third party purchaser of the
Property. Tenant's failure to deliver such estoppel certificate within said 10
business day period shall be deemed a material default by Tenant under this
Lease.

                  C.       SUBORDINATION. Landlord acknowledges and agrees
that a material term of this Lease and inducement for Tenant to accept its
terms is Landlord's obligation to use its good faith efforts to obtain for the
benefit of Tenant an agreement from each and every existing and future lender,
lien or security interest holder, deed of trust beneficiary, ground tenant and
other present and future holder of any interest superior to this Lease
provided such interest is valued at One Million Dollars ($1,000,000.00) or
more (each a "Senior Interest Holder") a non-disturbance agreement in form and
substance reasonably acceptable to such Senior Interest Holder and containing
not less than the following elements:

                  Each Senior Interest Holder shall agree that so long as no
                  Event of Default has occurred under the terms of the Lease:

                           (a)      The Lease shall not be terminated; and

                           (b)      Tenant's use, possession, occupancy or
                  enjoyment of the Leased Premises and Tenant's rights and
                  privileges under the Lease, or, any extensions, renewals or
                  modifications thereof, or substitutions therefor to which
                  Senior Interest Holder has consented, shall not be disturbed,
                  diminished or interfered with by Senior Interest Holder or by
                  any successor in interest resulting from any foreclosure, deed
                  in lieu of foreclosure or similar action, nor shall the
                  leasehold estate granted by the Lease be affected in any other
                  manner; and

                           (c)      Tenant shall not be joined or named as a
                  party defendant or otherwise in any foreclosure or any
                  action or proceeding instituted under or in connection with
                  the mortgage or other senior interest or in the event Senior
                  Interest Holder takes possession of the Leased Premises
                  pursuant to any provisions of the mortgage or other senior
                  interest; and

                           (d)      Neither the mortgage nor any other security
                  instrument executed in connection therewith or any other
                  senior interest shall be construed as subjecting in any manner
                  to the lien thereof, any trade fixtures, signs or other
                  personal property at any time furnished or installed by Tenant
                  or its sublessees or licensees on or in the Leased Premises;
                  provided, however, all fixtures and leasehold improvements in
                  the Leased Premises (other than those set forth in Exhibit G),
                  regardless of by whom such improvements were installed,
                  including, but not limited to, improvements which are so
                  annexed to or incorporated in the Leased Premises that they
                  have become a permanent

                                      -24-

<PAGE>

                  part of the Leased Premises and cannot be removed without
                  material injury thereto shall be subject to the lien of any
                  such Senior Interest Holder.

                  Accordingly, this Lease shall not be subordinate to any
ground lease, mortgage, deed of trust or similar senior interest, unless
Tenant is provided with a non-disturbance agreement in form reasonably
acceptable to Tenant and the Senior Interest Holder, executed by each Senior
Interest Holder Landlord agrees to use its good faith efforts to fulfill, at
Tenant's sole cost and expense, the foregoing obligation within sixty (60)
days following the later of (i) the Commencement Date, or (ii) the creation of
any such mortgage or other senior interest. Landlord's failure to satisfy the
foregoing obligation following written notice and a thirty (30) day
opportunity to cure, shall constitute an immediate default. Subject to
compliance with the foregoing, Tenant accepts this Lease, and the tenancy it
creates, subject and subordinate to any ground leases, security interests,
mortgages, deeds of trust or other financing arrangements, and/or any
extensions, modifications or amendments to them, which are or later will be a
lien, or affect or will affect all or any part of the Property. Subject to the
foregoing, Tenant agrees to execute, on request, any instruments which may be
reasonably required to subordinate Tenant's interest to such financing
arrangement.

                  D.       ATTORNMENT. Subject to Section C above, Tenant
agrees, upon the termination of Landlord's interest in the Leased Premises and
upon request, to attorn to the person or entity that holds title to the
reversion of the Leased Premises (the "Successor") and to all subsequent
Successors. Tenant also will pay to the Successor all rents and other sums
required to be paid by Tenant, and perform all of the other covenants,
agreements and terms required of Tenant under this Lease.

                  E.       LANDLORD'S LIABILITY. In the event of any arms
length bona fide transfer of title to the Property or Building (or an
assignment or sublease of either) to a third party transferee, solvent at the
time of the transfer, and transfer of the Deposit if not, yet applied,
Landlord will be entirely relieved of all covenants and obligations which
arise after such transfer.

                           Landlord at the time of this Lease's execution is a
Maryland limited liability limited partnership. No partner of such limited
liability limited partnership, as it may be constituted now or in the future,
will have any personal liability to Tenant and/or to anyone claiming under, by
or through Tenant. As to Landlord, recourse shall be had only to the extent of
Landlord's interest in the Building. It is understood that Tenant on the date
hereof is a corporation and that no person or party having an ownership
interest in Tenant shall have any personal liability for Tenant's obligations
under this Lease.

                  F.       AUTHORITY. Tenant warrants to Landlord that Tenant
is a corporation organized and validly existing in good standing under the
laws of the State of Delaware and qualified to transact business in the State
of Maryland. In addition, Tenant warrants to Landlord that this Lease has been
properly authorized and executed by Tenant and is binding upon Tenant in
accordance with its terms. Tenant's resident agent's name and address in the
State of Maryland are Charles Reinhart, 12111 Parklawn Drive, Rockville,
Maryland 20852. Tenant agrees to notify Landlord in writing of any change with
respect to its resident agent.

                  G.       NOTICES. Except as otherwise provided in this
Lease, any requirement for a notice, demand or request under this Lease shall
be satisfied only by a writing (a) hand delivered with receipt; (b) mailed by
United States registered or certified mail

                                      -25-

<PAGE>

or Express Mail, return receipt requested, postage prepaid; or (c) sent by
Federal Express or any other nationally recognized overnight courier service,
and addressed: (i) if to Landlord, c/o Manekin LLC, 7470 New Technology Way,
Suite B, Frederick, Maryland 21703; and to c/o Manekin, LLC, 7165 Columbia
Gateway Drive, Columbia, Maryland 21046, ATTENTION: General Counsel, with a
copy to Ann Clary Gordon, Esquire c/o Shapiro and Olander, 36 South Charles
Street, Baltimore, Maryland 21201; and (ii) if to Tenant, at the Leased
Premises, with a copy to Richard A. Cohn, Esquire, Bryan Cave, LLP, 700
Thirteenth Street, N.W., Washington, D.C. 20005-3960. All notices that are
sent in accordance with this Paragraph X.G. shall be deemed received by the
other party on the earliest of the following applicable time periods: (a)
three business days after being mailed. in the aforesaid manner; (b) the date
the return receipt is executed; or, (c) the date delivered as documented by
the overnight courier service or the hand delivery receipt. All rental
payments and other charges payable by Tenant under this Lease shall be
delivered to Landlord c/o Manekin LLC, 7165 Columbia Gateway Drive, Columbia,
Maryland 21046, ATTENTION: Accounting Department. Either party may designate a
change of address by written notice to the other party.

                  H.       SEVERABILITY, ENFORCEABILITY. If any provision of
this Lease, or its application to any person, is found invalid or
unenforceable, the remainder of this Lease or its application shall not be
affected. Each term and provision of this Lease shall be valid and enforceable
to the fullest extent permitted by law. Notwithstanding any language in this
Lease to the contrary, if the Lease Term does not commence on or before
January 1, 2010, this Lease shall automatically terminate, and neither party
shall have any further liability to the other.

                  I.       CAPTIONS. All headings contained in this Lease are
for convenience only. They are not to be treated as a summary construction of
the provisions to which they pertain.

                  J.       RECORDATION. If at any time, any lienholder or
other party which has a right to require Landlord to do so, requires the
recordation of this Lease, Tenant will execute such acknowledgements as may be
necessary to effect such recordation. If Landlord requires, or is required, to
record this Lease, it will pay all recording fees, transfer taxes and/or
documentary stamp taxes payable in connection with the recordation. If Tenant
records this Lease, it will make all such payments. Tenant will not record
this Lease without Landlord's prior consent which shall not be unreasonably
withheld, conditioned or delayed.

                  K.       SUCCESSORS AND ASSIGNS. This Lease and all of its
provisions, individually and collectively, will bind and inure to the benefit
of Landlord and Tenant, and their respective heirs, distributees, executors,
administrators, successors, personal and legal representatives and their
permitted assigns.

                  L.       COMMISSIONS. Tenant represents that Tenant has
dealt directly with only MANEKIN, LLC ("Manekin") and Scheer Partners, Inc.
("Scheer") as brokers in connection with this Lease and that, insofar as
Tenant knows, no other broker negotiated this Lease or is entitled to any
commissions in connection with it. Landlord shall pay Scheer and Manekin a
commission in accordance with a separate agreement between Landlord and Scheer
and Landlord and Manekin. Tenant will hold harmless and indemnify Landlord
from any costs incurred by Landlord arising out of any other broker's claim
that such other broker has assisted Tenant with respect to this Lease.

                                      -26-
<PAGE>

                  M.       QUIET ENJOYMENT. Landlord covenants to Tenant that,
so long as no Event of Default has occurred under this Lease Tenant shall
peaceably hold and enjoy the Leased Premises and the benefits afforded under
this Lease throughout the Lease Term without hindrance or impairment from
Landlord or those claiming by or through Landlord.

                  N.       FORCE MAJEURE. In the event that either party to
this Lease is delayed, hindered or prevented, by reason of organized labor
troubles, such as a strike or lockout, an inability to produce materials,
delays in transportation, failure of power, restrictive governmental laws or
regulations, riots, insurrection, war, fire or other casualties, acts of God,
rain or other weather conditions or any, other reason (excluding lack of
funds) not reasonably within the control of the party so delayed, hindered or
prevented, from performing work or doing any act required under the terms of
this Lease, then performance of such act shall be excused for the period of
the delay, and the period of the performance of any such act shall be extended
for a period equal to the period of such delay. Except as otherwise provided
herein, the occurrence of any event described in this Paragraph X.N. will not
operate to excuse Tenant from prompt payments of Rent, Additional Rent or any
other payments required by this Lease.

                  O.       WAIVER OF JURY TRIAL. Landlord and Tenant desire a
prompt resolution of any litigation between them with respect to this Lease.
To that end, Landlord and Tenant waive trial by jury in any action, suit,
proceeding and/or counterclaim brought by either against the other on any
matters whatsoever arising out of or in any way connected with this Lease, the
relationship of Landlord and Tenant, Tenant's use or occupancy of the Leased
Premises, any claim of injury or damage and/or any statutory remedy. This
waiver is knowingly, intentionally and voluntarily made by Tenant. Tenant
acknowledges that neither Landlord nor any person acting on behalf of Landlord
has made any representations of fact to induce this waiver of trial by jury or
in any way to modify or nullify its effect. Tenant further acknowledges that
it has been represented (or has had the opportunity to be represented) in the
signing of this Lease and the making of this waiver by independent legal
counsel, selected of its own free will, and that it has had the opportunity to
discuss this waiver with counsel. Tenant further acknowledges that it has read
and understands the meaning and ramifications of this waiver of jury trial.

                  P.       TENANT FINANCING AND LANDLORD'S LIEN. Landlord
agrees to cooperate with Tenant, at no cost to Landlord, in Tenant's
application for financing with the Maryland Industrial Financing Authority
("MIDFA") financing program for the construction of certain of Tenant's
improvements under this Lease. Landlord agrees that it shall waive, limit or
subordinate any lien it has or shall have to the lien of MIDFA or any
institutional lender (separately and collectively, the "Favored Party") on
Tenant's personal property; provided however, that this waiver, limitation or
subordination shall not prevent Landlord from exercising any right or remedy
against the Tenant to which Landlord may be entitled under the terms of this
Lease or as may be provided by applicable law, nor shall it prevent Landlord
from exercising its lien so long as Landlord recognizes the Favored Party's
prior right. Any document evidencing such waiver, limitation or subordination
by Landlord shall be in form and substance reasonably acceptable to Landlord
and such Favored Party. It is further understood and agreed that under no
circumstances shall Tenant's personal property include any fixtures and
leasehold improvements in the Leased Premises, regardless of by whom such
improvements were installed. Fixtures

                                      -27-

<PAGE>

and leasehold improvements are defined as all articles in the nature of
personal property or other improvements which are so annexed to or
incorporated in the Leased Premises that they have become a permanent part of
the Leased Premises and cannot be removed without material injury thereto.

                  Q.       ROOFTOP EQUIPMENT LICENSE. So long as this Lease is
in full force and effect and Tenant is not in default of any obligation on its
part to be performed hereunder, Tenant may, from time to time, at its expense,
but at no additional charge from Landlord except as otherwise provided herein,
with Landlord's consent, which consent shall not be unreasonably withheld,
conditioned or delayed, make rooftop penetrations, install conduits, exhausts
and exhaust, systems, erect, mechanical and other equipment on the roof of the
Building or surrounding site (the "Equipment") so long as the same do not
materially and adversely impact the aesthetics or functional integrity of the
Building in Landlord's reasonable opinion or void or diminish the roof
warranty of the Building, and subject to the terms and conditions set forth
below. Furthermore, Tenant shall make every effort to place any rooftop
Equipment within the boundaries of any existing roof screen.

                           (i)      Provided  Tenant occupies one hundred
percent (100%) of the Leased Premises, Landlord hereby grants to Tenant the
exclusive right to use and occupy the roof of the Building (the "Licensed
Space") for the purposes only of installing, erecting, operating and
maintaining the Equipment.

                           (ii)     Tenant for itself, its employees, agents
and contractors shall have free access to the Licensed Space to install,
service, operate, and maintain the Equipment subject to the reasonable rules
and regulations of Landlord promulgated from time to time.

                           (iii)    The term of this License shall be the
Lease Term.

                           (iv)     Upon the termination of the License,
Tenant shall remove the Equipment and repair any damage caused by said removal
at the License expiration and leave the Licensed Space in the same order and
repair as when received by Tenant, reasonable wear and tear excepted. Tenant
covenants to pay to Landlord within twenty (20) days of written notice, the
cost of repairing any damage to the Building resulting from the operation or
maintenance of the Equipment.

                           (v)      Tenant shall throughout the term of this
License maintain the Equipment and the portion of the Licensed Area affected
by such Equipment in accordance with reasonable and customary engineering
standards and in conformity with any requirements of all public authorities
having jurisdiction over Tenant.

                           (vi)     Tenant, at its expense, must obtain all
necessary zoning and government approvals, as well as approvals required by
any Property covenants.

                           (vii)    The Equipment must be limited to Tenant's
business and Tenant shall not license the Licensed Space to others.

                           (viii)   This License is not assignable by Tenant.

                           (ix)     Tenant shall use only contractors and
subcontractors approved by Landlord in connection with any work to be
performed by Tenant on or about the Licensed Space.

                                      -28-

<PAGE>

                  R.       MISCELLANEOUS.

                           1.   As used in this Lease, and where the context
requires: (a) the masculine shall be deemed to include the feminine and neuter
and vice-versa; and (b) the singular shall be deemed to include the plural and
vice-versa.

                           2.   This Lease is made in the State of Maryland
and shall be governed in all respects by the laws of the State of Maryland.

                           3.   Except as otherwise specifically provided in
this Lease, no abatement, refund, offset, diminution or reduction of Rent or
any other payments will be claimed by or allowed to Tenant, or any person
claiming under Tenant (including inconvenience, discomfort, interruption of
business or otherwise), because of any present or future governmental laws or
ordinances, or because of any other cause or reason whatsoever.

                           4.   All plats, exhibits, riders or other
attachments to this Lease are a part of this Lease and are incorporated by
reference into this Lease.

                           5.   THIS LEASE  CONTAINS THE ENTIRE  AGREEMENT
BETWEEN LANDLORD AND TENANT REGARDING THE SUBJECT MATTER OF THIS LEASE. THERE
ARE NO PROMISES, AGREEMENTS, CONDITIONS, UNDERTAKINGS, WARRANTIES OR
REPRESENTATIONS, ORAL OR WRITTEN, EXPRESS OR IMPLIED, BETWEEN THEM, RELATING
TO THIS SUBJECT MATTER, OTHER THAN AS SET FORTH IN THIS LEASE. THIS LEASE IS
INTENDED BY LANDLORD AND TENANT TO BE AN INTEGRATION OF ALL PRIOR OR
CONTEMPORANEOUS PROMISES, AGREEMENTS, CONDITIONS, NEGOTIATIONS AND
UNDERTAKINGS BETWEEN THEM. THIS LEASE MAY NOT BE MODIFIED ORALLY OR IN ANY
MANNER OTHER THAN BY AN AGREEMENT IN WRITING SIGNED BY LANDLORD AND TENANT OR
THEIR RESPECTIVE SUCCESSORS IN INTEREST. THIS LEASE MAY BE EXECUTED IN
COUNTERPARTS, EACH OF WHICH SHALL BE AN ORIGINAL, BUT ALL OF WHICH SHALL
CONSTITUTE ONE AND THE SAME LEASE.

                           6.   Three (3) riders are attached to this Lease
and made a part of it.

                  IN WITNESS WHEREOF, Landlord and Tenant have respectively
signed this Lease Agreement under seal as of the date first above written.

                                           LANDLORD:

WITNESS:                                   MOR BENNINGTON LLLP

                                           By: RA & FM, INC., General Partner

/s/ Signature Illegible                    By: /s/ Signature Illegible (SEAL)
                                               Name: Alton D. Fryer
                                                     --------------
                                               Title: Vice President
                                                      --------------

                                           TENANT:

WITNESS/ATTEST:                            GENVEC, INC.

/s/ Signature Illegible                    By: /s/ Signature Illegible (SEAL)
                                               Name: Jeffrey W. Church
                                                     ----------------
                                               Title: CFO
                                                      ---
                                                      Authorized Officer

                                      -29-

<PAGE>

STATE OF MARYLAND                   )
                                    ) TO WIT:
COUNTY OF FREDERICK                 )

                  I HEREBY CERTIFY that on this 30 day of April, 1999, before
         me, the subscriber, a Notary Public of the State of Maryland, County of
         FREDERICK, personally appeared, ALTON D. FRYER of RA & FM, Inc.,
         general partner of MOR BENNINGTON LLLP, Landlord, and he acknowledged
         the foregoing Lease Agreement to be the act and deed of such limited
         liability limited partnership.

                  WITNESS my hand and Notarial Seal.

                                                        /s/ Signature Illegible
                                                                 Notary

My Commission Expires: 12-01-01
                       --------
STATE OF MARYLAND                           )
                                            ) TO WIT:
CITY/COUNTY OF MONTGOMERY                   )
               ----------

                  I HEREBY CERTIFY that on this 30th day of April, 1999, before
      me, the subscriber, a Notary Public of the State of MARYLAND, City/County
      of MONTGOMERY, personally appeared PAUL H. FISCHER, PH.D., the President
      of GENVEC, INC., Tenant, and [she] [he] acknowledged the foregoing Lease
      Agreement to be the act and deed of such corporation.

                  WITNESS my hand and Notarial Seal.

                                                        /s/ Signature Illegible
                                                                  Notary

My Commission Expires: July 26, 2000
                       -------------

                                      -30-

<PAGE>

                                   RIDER NO. 1

                             Right of First Refusal
                             ----------------------

                  During the term of this Lease and any and all extensions
thereof, and subject and subordinate to any previously granted rights to
others (such as those granted to H. T. Medical of which Tenant has been
advised), including, without limitation, renewal rights, expansion rights,
rights of first refusal and rights of first offer Tenant shall have the right
of first refusal (the "First Refusal Right") to lease any space on the first
floor or second floor of the adjacent two story building, located on Parcel J,
at 55 West Watkins Mill Road, Gaithersburg, Maryland (the "Expansion Space"),
after Landlord's initial leasing thereof, on the terms, inclusive of any
market concessions (i.e. tenant improvement allowances) and at a Basic Annual
Rent equal to the price per square foot as is sought to be leased by a bona
fide prospective tenant of the Expansion Space and acceptable to Landlord (the
"Offer"). An Offer shall not include the exercise by another tenant of the
Building of its rights of renewal or expansion or Landlord's decision to allow
on existing tenant to continue its occupancy whether or not such tenant's
lease contains a right to so renew or extend it's lease. Notwithstanding
anything to the contrary, (i) Landlord (including, without limitation, any and
all successors to Landlord) shall have the continuing obligation to comply
with the terms of the First Refusal Right and to submit any and all future
Offers to Tenant as provided herein and (ii) the rights of Tenant described in
this Rider No. 1 shall remain in effect and shall be continuous and on-going
throughout the term of the Lease, including all extension and renewal periods.
If Landlord receives or makes a bona fide Offer to lease all or any portion of
the Expansion Space, Landlord shall afford Tenant the First Refusal Right for
such area as encompassed by such Offer. Landlord shall not lease such area,
without first advising Tenant of the terms and conditions of the Offer and
offering Tenant in writing the right to lease such area on the same terms and
conditions, nor shall Landlord accept such Offer, unless such acceptance is
subject to Tenant's rights described herein. The information furnished to
Tenant relative to such Offer shall include all of the terms and conditions of
the transaction, including, without limitation, disclosure of all payment and
credit terms and accommodations and Landlord's construction obligations, and
all such other details as are reasonably necessary for Tenant to evaluate the
terms and context of the Offer.

                  Tenant's exercise of its First Refusal Right shall be
effective only upon written notification (the "Notice") by Tenant to Landlord
thereof. Such notification must be given to Landlord before the close of
business ten (10) full business days after Tenant's receipt of Landlord's
written notification to Tenant of the Offer. Time is of the essence with
respect to Tenant's exercise of its rights under this Rider, and Tenant
acknowledges that Landlord requires strict adherence to the requirement that
the Notice be timely made and in writing.

                  In the event Tenant fails to so notify Landlord within said
ten (10) day period, Landlord shall be free to accept the Offer and Tenant
shall have no further rights hereunder.

                  This First Refusal Right is personal to Tenant and shall not
be separated from the Lease or transferred by Tenant independently of the
leasehold interest without the prior written consent of Landlord, which
consent of Landlord will be given solely within the discretion of Landlord.

                                      -31-

<PAGE>

                  Notwithstanding any other provision hereof, the following
provisions shall apply to the First Refusal Right and to Tenant's lease, if
any, of the Expansion Space:

                           (i)      Tenant shall not be entitled to exercise
the rights accorded to Tenant in the first paragraph, unless at the date of
such exercise or at the date on which Tenant's lease of the Expansion Space
becomes effective, Tenant is in possession of the Leased Premises and an Event
of Default does not exist at the time of the exercise or on the Expansion
Space Commencement Date, as hereinafter defined;

                           (ii)     Tenant shall have the right to lease and
occupy the Expansion Space commencing on the date set forth in the Offer (the
"Expansion Space Commencement Date"), and terminating on the later of (a) the
date set forth in the Offer, or (b) the expiration of the Lease Term under
this Lease, on such other terms, conditions, and provisions as are set forth
in the Offer;

                           (iii)    The Expansion Space shall be delivered to
Tenant in "As Is" condition unless otherwise stated in the Offer; and

                           (iv)     Except as otherwise expressly provided in
this Rider or in the Offer, all of the covenants, terms, conditions and
agreements set forth in this Lease shall apply to the Expansion Space.

                           (v)      The Lease  shall be amended, as may be
appropriate, to reflect the leasing of the Expansion Space.

                                      -32-
<PAGE>

                                   RIDER NO. 2

                            Building Expansion Space

                  At anytime during the Lease Term and provided (i) at least
four (4) years remain following completion of the expansion improvements or
Tenant elects to so extend the Lease Term and (ii) Tenant is occupying at least
fifty percent (50%) of the Leased Premises and remains liable for the entirety
of the Leased Premises, upon Tenant's written request, and upon supplying
Landlord with adequate information, in Landlord's estimation, of Tenant's
financial ability to pay for the costs outlined herein, Landlord shall, at the
sole cost and expense of Tenant, make a good faith attempt to obtain approval
from the City of Gaithersburg, or any other applicable governmental authority,
to expand the Leased Premises by no less than ten thousand (10,000) square feet
(the "Building Expansion Space"). Tenant shall pay all of Landlord's costs and
expenses in connection with such approval process including all design and
architectural fees and permit fees in connection therewith within five (5) days
after Tenant's receipt of Landlord's invoice(s) for same. In the event such
approval is obtained and Tenant elects to proceed with the Building Expansion
Space, Landlord shall construct the Building Expansion Space in accordance with
plans and specifications to be prepared by Tenant's architect and approved by
Landlord (the "Building Expansion Space Plans and Specifications"). Prior to
Landlord commencing construction, however, Landlord and Tenant shall enter into
an amendment to this Lease for purposes of evidencing the parties' agreement
with respect to said Building Expansion Space. The Competitive Bid Procedure
outlined in Exhibit D-1 shall apply to Landlord's construction of the Building
Expansion Space. Tenant acknowledges that the construction of the Building
Expansion Space may disrupt or interfere with Tenant's use of the Leased
Premises, but under no circumstances will there be an abatement of Tenant's
monetary or non-monetary obligations under this Lease during the construction of
the Building Expansion Space. Landlord's costs and expenses in connection with
such construction (including the same general contractor fee and general
conditions fee rate set forth in paragraph I.B.2. above) shall be repaid by
Tenant to Landlord in equal monthly installments together with the monthly rent
payments, which installments shall be determined by amortizing Landlord's costs
and expenses together with 300 basis points over the prime rate then being
charged by First National Bank (or its successor) over the remaining Lease Term,
as defined herein (including any renewal exercised by Tenant). Notwithstanding
the foregoing, Tenant shall have the right to prepay Landlord's costs and
expenses or self-fund same at the time of the approval of the Building Expansion
Space Plans and Specifications.

                                      -33-
<PAGE>

                                   RIDER NO. 3

                                 Renewal Option

                       Rider to Section IIA. (Lease Term)

         Provided (i) Tenant is still occupying at least fifty percent (50%) of
the Leased Premises, (ii) this Lease is then in full force and effect, (iii) no
Event of Default exists either on the date Tenant elects to extend the term or
on the date the extended term commences, and, (iv) Tenant has not failed more
than two times during the preceding Lease Year to pay any payments called for by
this Lease on the date such payment is due, then Tenant shall have the right to
extend the term of this Lease for two (2) terms of five (5) years each
immediately following the expiration of the then current Lease Term on the same
terms, conditions, and provisions as are set forth in this Lease, save that:

                           (i)  there shall be no further right of extension,
after the second renewal term, and

                           (ii) the Basic Annual Rent payable with respect to
the Leased Premises shall be adjusted to reflect ninety-five percent (95%) of
the then prevailing rental rate (but in no event less than ninety percent
(90%) of the then current Basic Annual Rent) for first-class office space
within Bennington Corporate Center as of the commencement of the applicable
renewal term (as determined below).

         Tenant shall be deemed to have waived the right to exercise this
renewal option unless not less than nine (9) months prior to the date of
termination of the initial Lease Term (or Extended Lease Term, if applicable) or
the first renewal term, as the case may be, Tenant shall have notified Landlord
in writing of Tenant's election to renew (the "Renewal Notice"). Landlord shall
give Tenant written notice of its good faith determination of the prevailing
rental rate within thirty (30) days after Landlord's receipt of the Renewal
Notice (the "Rent Notice"). Tenant may elect to have the prevailing rent
determined, as set forth below, if it does not agree with Landlord's
determination thereof, provided it gives Landlord written notice (the "Appraisal
Notice") within fifteen (15) business days after Tenant's receipt of the Rent
Notice.

         Within five (5) business days after Landlord receives the Appraisal
Notice from Tenant, Landlord and Tenant shall give written notice to the other
that each, at its own expense, has hired and appointed a disinterested real
estate broker of recognized competence and professional experience as a broker
of comparable commercial and industrial real estate in the Washington
Metropolitan Area. The two brokers thus appointed shall mutually agree upon the
appointment of a third broker, the cost of which shall be shared equally by
Landlord and Tenant, which broker shall also be a disinterested person of
recognized competence and professional experience as a broker of comparable
commercial and industrial real estate in the Washington Metropolitan area. In
the event that the two brokers shall be unable to agree within ten (10) days
after their appointment on the appointment of the third broker, then Tenant
shall choose three brokers from which Landlord shall chose one who shall serve
as the third broker. Landlord shall notify Tenant of the selection of the third
broker within ten (10) days after Tenant's notice to Landlord of the selection
of such three brokers from which Landlord is to choose. The third broker shall,
as promptly as possible, but in no event more than thirty (30) days after the
date of his or her selection, conduct an appraisal of the Building for purposes
of determining the then

                                      -34-
<PAGE>

prevailing rental rate therein. In determining the prevailing rental rate, the
appraisal shall take into account market conditions such as the typical length
of lease terms and the economic value of any concessions then customarily being
provided to tenants of like size and creditworthiness in connection with Leases
for such space, such as tenant build-out allowances. Upon completion of the
appraisal, the third broker shall immediately give written notice to the parties
hereto stating his or her determination, and shall furnish to each party hereto
a copy of such determination signed by him or her, which determination shall be
final and binding on the parties.

         Time is of the essence with respect to Tenant's exercise of its right
under this Rider and Tenant acknowledges that Landlord requires strict adherence
to the requirement that the Renewal Notice and the Appraisal Notice be timely
made and in writing.

                                      -35-
<PAGE>

                                    EXHIBIT A

                         DESCRIPTION OF LEASED PREMISES

         [Include location of (1) Leased Premises; and (2) location of permitted
         Tenant parking and loading areas.]

<PAGE>

                                 [CHART OMITTED]

<PAGE>

                                    EXHIBIT B

                     BASE BUILDING PLANS AND SPECIFICATIONS

<PAGE>

                                    EXHIBIT C

                           TI PLANS AND SPECIFICATIONS

<PAGE>

                                   EXHIBIT D-1

                   TENANT IMPROVEMENTS CONSTRUCTION AGREEMENT

<PAGE>

                                   EXHIBIT D-1

                   Tenant Improvements Construction Agreement

                                TABLE OF CONTENTS

1.       Definitions                                                          1

2.       Representatives                                                      2

3.       Project Design and Construction                                      2

4.       Landlord's Approval                                                  2

5.       Schedule of Improvement Activities                                   3

6.       Tenant's Work                                                        6

7.       Disclaimer of Liability                                              6

8.       Cost Responsibilities                                                7

9.       Change Orders                                                        7

10.      Completion                                                           7

11.      Confirmation Upon Completion                                         7

12.      Lease Commencement                                                   8

Exhibit D-3       Construction Schedule

Exhibit D-4       Non-Binding Estimate

<PAGE>

                   TENANT IMPROVEMENTS CONSTRUCTION AGREEMENT

         THIS TENANT IMPROVEMENTS CONSTRUCTION AGREEMENT ("TI Agreement") is
dated April ______, 1999, between MOR BENNINGTON LLLP. having an office and
place of business at 7470 New Technology Way, Suite B, Frederick, Maryland 21703
as Landlord (hereinafter called "Landlord"), and GENVEC, INC., having its
principal office and place of business at 12111 Parklawn Drive, Rockville,
Maryland 20852, as Tenant (hereinafter called "Tenant").

                                    RECITALS

         This TI Agreement is attached to and forms a part of that certain Lease
Agreement dated of even date herewith ("Lease"), pursuant to which Landlord has
leased to the Tenant the entire single story building (the "Building") located
at 65 West Watkins Mill Road, Gaithersburg, Maryland 20879 (the "Leased
Premises"), situated in the Bennington Corporate Center. Unless otherwise
indicated, the capitalized terms herein shall have the same meaning ascribed to
them in the Lease. Landlord desires to see that certain Tenant Improvements are
made to the Leased Premises, and Tenant desires to have Landlord make such
Tenant Improvements, upon the terms and conditions contained in this TI
Agreement.

         1.       DEFINITIONS. In this TI Agreement, some defined terms are
used. Such terms and agreements relating to them include the following:

                  (a)      TENANT'S REPRESENTATIVE: Jeffrey W. Church.

                  (b)      LANDLORD'S REPRESENTATIVE: Alton Fryer, III.

                  (c)      GENERAL CONTRACTOR'S REPRESENTATIVE: Craig Wess.

                  (d)      ARCHITECT: Gaudreau, Inc., or any other architectural
firm selected and employed by Tenant and acceptable to Landlord in connection
with the construction of the Tenant Improvements.

                  (e)      TENANT CONSTRUCTION ALLOWANCE: Landlord shall
contribute to the costs and expenses incurred in connection with the
construction of the Tenant Improvements in accordance with Section I.B.2 of the
Lease. Tenant shall pay for the cost of Tenant Improvements in accordance with
Section I.B.2. of the Lease. Landlord and Tenant's monetary obligations with
respect to the Tenant Improvements are collectively referred to herein as the
"Tenant Construction Allowance."

                  (f)      CONSTRUCTION INFORMATION: Any and all information
that is necessary for Tenant's Architect to prepare the TI Plans and
Specifications. Tenant hereby acknowledges that the Construction Information has
been previously supplied and/or made available to Tenant and is acceptable to
Tenant.

                  (g)      ESTIMATED LEASED PREMISES COSTS: The preliminary
estimate of the costs of the Tenant Improvements prepared in accordance with the
requirements of the Section below, captioned "Estimation of Costs."

                  (h)      TI PLANS AND SPECIFICATIONS: Construction documents
detailing the Tenant Improvements and conforming to applicable codes, complete
in form and content and containing sufficient information and detail to allow
for competitive bidding or negotiated pricing by contractor(s) selected by
General Contractor and Tenant and to allow the selected contractor to construct
the Tenant Improvements.

                  (i)      CONSTRUCTION SCHEDULE: The schedule depicting the
relative time frames for the activities related to the construction of the
Tenant Improvements in the Leased Premises which is attached hereto as Exhibit
D-3.

<PAGE>

                  (j)      IMPROVEMENTS COST PROPOSAL: As defined below in
Paragraph 5(h).

                  (k)      MAXIMUM APPROVED COST: The sum of the Tenant
Construction Allowance and any additional amount that Tenant has agreed to pay
for the Tenant Improvements pursuant to the Lease and this TI Agreement.

                  (l)      TENANT IMPROVEMENTS: The Tenant Improvements to the
Leased Premises constructed pursuant to the TI Plans and Specifications.

                  (m)      LEASED PREMISES COST: The cost of the Tenant
Improvements includes, but is not limited to the following:

                           (1)      The actual cost of all Tenant and Landlord
approved labor and materials fees and expenses;

                           (2)      The actual cost of all Tenant and Landlord
approved contractor costs and fees, overhead, profit, and contractor fees.

                  (n)      CHANGE ORDER: Any change, modification, or addition
to the TI Plans and Specifications after Tenant and Landlord have approved the
same.

                  (o)      GENERAL CONTRACTOR: Manekin, LLC.

                  (p)      TENANT'S CONSTRUCTION ADMINISTRATOR: The construction
administrator, if any, contracting with Tenant and selected by Tenant, in
Tenant's discretion, which may, at Tenant's election, be the Architect.

                  (q)      TENANT'S ENGINEER(S): The structural, mechanical and
electrical engineer(s) contracting with Tenant and selected by Tenant, in
Tenant's discretion.

                  (r)      TENANT APPROVAL. Whenever in this TI Agreement,
Tenant's consent, approval, review, participation or any such similar act is
required, such consent or approval shall be deemed given and review or
participation shall be deemed waived, unless a contrary written response, in
reasonable detail, is given within five (5) business days after the requesting
party has submitted the item for consent, approval, review, participation or
such similar act to Tenant.

         2.       REPRESENTATIVES. General Contractor appoints General
Contractor's Representative to act for General Contractor in all matters
associated with this TI Agreement. Tenant appoints Tenant's Representative to
act for Tenant in all matters associated with this TI Agreement. Either
representative may appoint a substitute or successor representative, so long as
such designation is effected by written notice in accordance with the notice
provisions of the Lease. All inquiries, requests, instructions, authorizations,
and other communications with respect to the matters covered by this TI
Agreement (collectively, "Communications") shall be made to General Contractor's
Representative or Tenant's Representative, as the case may be. General
Contractor's Representative and Tenant's Representative shall be responsible for
communicating to the Architect, Tenant's Construction Administrator, Tenant's
Engineer(s) and to one another Communications which are pertinent to the
construction of the Tenant Improvements.

         3.       PROJECT DESIGN AND CONSTRUCTION. All work will be performed by
the contractors selected by General Contractor and Tenant in accordance with
this TI Agreement and, unless otherwise provided, such contractors shall be
engaged by General Contractor.

         4.       LANDLORD'S APPROVAL. Landlord may only withhold its approval
of the TI Plans and Specifications or Change Order(s) that in its reasonable
discretion:

                  (a) Exceeds the capacity of or materially and adversely
affects the structural or aesthetic integrity or future marketability of the
Building or the Leased Premises, or any part of the heating, ventilating, air
conditioning, plumbing, mechanical, electrical, or other systems of the Building
or the Leased Premises. The agreed upon live load limit for the slab of the Base
Building is 125 p.s.f.

                                       -2-
<PAGE>

                  (b) Does not conform to applicable building codes or is not
approved (or is not likely to be approved) by any governmental,
quasi-governmental, or utility authority with jurisdiction over the Leased
Premises. Notwithstanding the preceding sentence Landlord has no obligation to
verify such conformance of the TI Plans and Specifications, which are solely the
responsibility of Tenant in accordance with Section I.B.2 of the Lease.

         5.       SCHEDULE OF IMPROVEMENT ACTIVITIES.

                  (a)      TIMETABLE. Provided Tenant adheres to the Tenant
Deadlines set forth on Exhibit D-2 to the Lease, General Contractor shall adhere
to the Construction Schedule attached hereto as D-3, which respective timetables
may be altered only in accordance with the terms of this TI Agreement or by
mutual written consent of General Contractor, Landlord, and Tenant, which shall
be deemed given unless a contrary written response, in reasonable detail, is
given to the others within five (5) business days of request therefor. To the
extent Tenant does not meet the Tenant Deadlines Construction Schedule the
Construction Schedule shall likewise be lengthened. and such failure results in
a delay in the

                  (b)      DESIGN MEETINGS. During the design phases (which
commenced prior to the execution of this TI Agreement) of the Tenant
Improvements, if Tenant shall meet with the Architect to review and discuss the
significant aspects of the design documents as then completed, Landlord's
Representative shall attend such meetings as and when requested by Tenant,
provided reasonable prior notice has been given to Landlord's Representatives.

                  (c)      ESTIMATION OF COSTS. Within eighteen (18) days after
approval of the TI Plans and Specifications, Landlord will promptly cause to be
prepared in consultation with outside contractors, subcontractors and suppliers,
a preliminary estimate of the Leased Premises Cost (the "Estimated Leased
Premises Cost"). Such estimate shall identify separately the amount of the
Estimated Leased Premises Cost attributable to each separate trade, subcontract
and category of the work and unit prices and quantities for each line item of
the components thereof which shall be used to compute the cost implications of
changes in the scope of work. Upon receipt by Tenant of the Estimated Leased
Premises Cost, Tenant may either approve the TI Plans and Specifications or
require Architect to revise the TI Plans and Specifications by the deadline
established in the Construction Schedule or within 5 days after the date of
Tenant's receipt of the Estimated Leased Premises Cost, whichever is later, in
order to assure that the Estimated Leased Premises Cost is consistent with the
Tenant Improvements budget established by Tenant for competitive bidding.

                  As stated above, Tenant shall be afforded the opportunity to
redesign and revise the TI Plans and Specifications. All costs and expenses of
such redesign and delays, including but not limited to any increases in the bid
amounts, associated therewith shall be borne by Tenant and shall not delay the
Commencement Date of the Lease, which, unless occupancy occurs earlier, shall be
November 1, 1999.

                  Based on preliminary and cursory evaluations and estimates as
reflected on Exhibit D-4 attached hereto prepared by General Contractor based on
schematic plans and narrative specifications dated February 8, 1999 prepared by
Tenant's Architect which were modified as a result of an ongoing so-called
"value engineering" process which was finalized on or about April 14, 1999, the
preliminary estimate of what the Estimated Leased Premises Costs could be is
approximately Five Million Twenty-Two Thousand Five Hundred Eighty-Six Dollars
($5,022,586.00). However, the parties hereto acknowledge that this is a
non-binding estimate and has no impact upon the parties' rights and obligations
under this TI Agreement or the Lease.

                  (d)      LANDLORD AND TENANT WORK. Tenant, concurrent with
Tenant's approval of the TI Plans and Specifications, may request of Landlord in
writing that Tenant be allowed to provide certain materials or elements of the
Tenant Improvements or reserve for performance by contractors selected by Tenant
distinct elements of the Tenant Improvements which are furniture, fixtures and
equipment (said elements of the Tenant Improvements referred to in this TI
Agreement as "Tenant's Work"). Landlord shall promptly approve or disapprove of
such request in its reasonable discretion. If so approved, construction and
installation of the Tenant's Work shall be Tenant's sole responsibility
(provided that Tenant may apply the Tenant Construction Allowance to the cost of
Tenant's Work). The progress of Tenant's Work shall not delay the Commencement

                                       -3-
<PAGE>

Date of the Lease, which, unless occupancy occurs earlier, shall be November 1,
1999. All work which is not Tenant's Work shall be referred to herein as
"Landlord's Work".

                  (e)      SELECTION OF POTENTIAL SUBCONTRACTORS. Landlord and
Tenant shall develop a mutually agreeable list of not less than three (3)
qualified subcontractors for each separate trade or category of the work and
from such list Landlord shall bid Landlord's Work. Development of the above list
shall be based upon Landlord's and Tenant's respective evaluations of the
potential subcontractor's reliability and reputation for quality personnel
including the project workmanship and timeliness of performance, the
subcontractor's financial capability to perform a project of the type and size
contemplated by this TI Agreement, the subcontractor's past job performance, and
the ability of the bidding subcontractor to satisfy licensing and insurance
requirements for the job. All potential subcontractors on the list shall have
had experience in constructing facilities of the type contemplated in respect of
the Leased Premises. In selecting the potential subcontractors to be included on
the list, both Landlord and Tenant shall be allowed to eliminate any potential
subcontractor it reasonably determines is not qualified or competent or, in the
exercise of their reasonable judgment, is otherwise unacceptable.

                  (f)      BID SOLICITATION. The bid solicitation package and
subcontracts shall require the subcontractors to state delivery dates (subject
to Tenant's Work being performed in a timely and cooperative fashion) for all
items of work and subcontractor furnished equipment and materials. General
Contractor will solicit bids for the construction of the Landlord's Work in such
fashion as to require each bidder to identify separately the amount attributable
to each separate trade or category of the work. The bid solicitation package
shall be prepared by Architect and General Contractor and shall be approved or
disapproved by Tenant within five (5) business days following receipt. Such
package shall include the following and such other items as may be reasonably
required by General Contractor or Architect:

                  (1)      Plans and Specifications: a complete set of drawings
                           for the scope of the work for the portion of the
                           Tenant Improvements to be constructed and detailed
                           specifications for the work to be performed.

                  (2)      Standard (broken down in CSI format) Response Format:
                           specific line items by trade, general conditions and
                           fees.

                  (3)      Statement of Unit Prices: A requirement that each
                           bidder shall state that additions to and deletions
                           from line item components shall be at the original
                           unit price.

                  (4)      Insurance Coverage: A requirement that each bidder
                           shall state the scope and amount of its insurance
                           coverage, to provide evidence of coverage of a type
                           and amount, acceptable to Tenant and provide a
                           certificate of insurance prior to commencement of any
                           work naming Landlord and General Contractor, as
                           additional insureds.

                  (5)      Statement of Financial Condition: A requirement that
                           each  bidder  submit  an AIA  305  Contractor
                           qualification form.

                  (6)      Construction Schedule: A requirement that each bidder
                           shall provide a proposed schedule of construction, in
                           sufficient detail that no activity have a duration
                           greater than two weeks. The schedule shall be
                           submitted in both written and electronic media, if
                           possible.

                  (7)      Bond: Each bidder shall state its current bonding
                           limit as well as its current capacity.

                  (8)      Markup: Each subcontract bidder shall state and bid
                           its proposed mark-up for combined overhead and profit
                           separately for Change Orders.

                  (g)      Review of Bids. The selection of subcontractors will
be based on the review of the bids submitted with respect to each such category,
and subject to the reasonable approval of

                                       -4-
<PAGE>

Tenant as to amounts for categories of the work that are either the payment
responsibility of Tenant under the Lease or are to be applied against the Tenant
Construction Allowance. Tenant's Representative, Tenant's Architect and Tenant's
Construction Administrator, if any, each shall have the right to reasonably
revise and approve all categories for which Tenant has payment responsibility
under the Lease or are to be applied against the Tenant Construction Allowance,
and shall have a one-time right to require General Contractor to reallocate the
amounts in each category; provided however, there shall be no right to an
adjustment of the General Contractor's fees or general conditions fee. Landlord
shall afford Tenant the opportunity to revise the TI Plans and Specifications
and other requirements to bring the Tenant Improvements into conformity with
Tenant's budget requirements (but any such changes shall be subject to
Landlord's approval) and shall cooperate with Tenant and the Architect to
achieve completion of such changes INTER ALIA, by promptly providing information
available to Landlord regarding costs and the estimated effect of the proposed
revisions on the completion of the Tenant Improvements. General Contractor shall
state estimated delivery dates for all items of work, equipment and materials.
Tenant's Architect and Tenant's Construction Administrator, if any, each shall
have the right to participate and attend the opening of all bids submitted by
potential subcontractors. In connection with any negotiations or discussions
with any bidders regarding their proposals (including any negotiations as to
revisions in the amounts of their bids), Tenant's Architect and Tenant's
Construction Administrator, if any, each shall have the right to participate
with respect to negotiations regarding categories which are to be applied
against the Tenant Construction Allowance. Notwithstanding the foregoing, it is
understood that no such participation, revisions or negotiations initiated on
Tenant's behalf shall delay the Commencement Date of the Lease, which, unless
occupancy occurs earlier, shall be November 1, 1999.

                  (h)      IMPROVEMENTS COST PROPOSAL. General Contractor will
notify Tenant in writing of the amount of the lowest bid from among the bids
received, which are responsive to the bid solicitation package. General
Contractor and Tenant may select any bidder, even though such bidder is not the
lowest bidder. The sum of the bids selected plus the General Contractor's fees
and general conditions fee shall be the Improvements Cost Proposal. Tenant will
either (1) agree to the amount of the Improvements Cost Proposal if it is the
same or less than the total of (a) Landlord's Initial Contribution; (b) Tenant's
Minimum Contribution; and (c) two times the amount of Landlord's Additional
Contribution (the "Total Allowance"), or (2) if greater than the Total
Allowance, agree in writing to pay the amount by which the Improvements Cost
Proposal exceeds the Total Allowance or request the Architect to revise the TI
Plans and Specifications in order to assure that the Improvement Cost Proposal
is not more than an amount to which Tenant agrees. General Contractor shall not
approve any contract, any contract amendment or take any action which will
increase the Maximum Approved Cost without the prior written consent of Tenant.

                  (i)      AWARD OF SUBCONTRACTS: The subcontractors agreed to
be accepted shall be "General Contractor's Subcontractors" and shall be awarded
the subcontracts for the Landlord's Work. General Contractor's Subcontractors
shall contract with General Contractor and shall be paid by General Contractor,
provided Landlord and Tenant perform their obligations under the Lease. Provided
Tenant timely performs its obligations under the Lease, Tenant shall not be
liable for claims by General Contractor's Subcontractors.

                  (j)      GOVERNMENTAL APPROVALS: Following approval and
completion of the TI Plans and Specifications, the Improvements Cost Proposal
and the Maximum Approved Cost, Tenant's Architect, at Tenant's sole cost and
expense, will cause application to be made to the appropriate governmental
authorities for necessary construction approvals and building permits. Upon
receipt of the necessary approvals and permits, General Contractor will begin
construction of the Landlord's Work. It shall be Tenant's, and not General
Contractor's, responsibility to obtain, at Tenant's sole cost and expense, all
necessary approvals and permits with respect to Tenant's Work and use of the
Leased Premises.

                  (k)      CONSTRUCTION PROGRESS MEETINGS: Beginning with the
commencement of construction, at the request of Tenant, the General Contractor
shall hold progress meetings (no more often than once a week) at the Leased
Premises, or at such other places as are acceptable to General Contractor and
Tenant. At such meetings, the progress of the work to be performed hereunder
shall be reported in detail with reference to the Construction Schedule, and all
problems or other issues relating to the same shall be discussed and resolved.
Each of General Contractor's

                                      - 5 -
<PAGE>

Subcontractors then performing work on the Tenant Improvements shall have a
knowledgeable representative present at each weekly meeting to report on the
condition of his work and to receive information regarding the performance of
future work by the Subcontractor. The General Contractor shall hold such
meetings within at least three (3) days after Tenant's request for any meeting
to held as required herein and shall allow Tenant's Representative, Tenant's
Construction Administrator, if any, Tenant's Engineer, if any, and the Architect
to attend and participate in each such meeting. The General Contractor shall
keep minutes of each such meeting held and shall circulate the minutes of each
meeting to Tenant's Representative, Tenant's Construction Administrator, if any,
Tenant's Engineer, if any, the Architect, and all Subcontractors (and such other
persons as may be appropriate), no later than three (3) working days after the
meeting is concluded. If such minutes reflect authorization for any Change
Order, the same shall not be effective until and unless approved by Tenant's
Representative and Landlord's Representative in accordance with Section 10,
below.

         6.       TENANT'S WORK. Tenant's consultants shall have access, at the
times and in the manner set forth below, to the Leased Premises during the
construction period to install cabling, wiring and Tenant's equipment and
fixtures ("Tenant's Installations"). With respect to Tenant's Work or
Installations, Tenant shall have the right to retain contractors, union or
non-union to fabricate millwork, including shelving, work surfaces, etc., and to
install equipment, subject only to obtaining the prior written approval of
Landlord and shall have the right to perform data and phone switch installation
using its own employees, contractors and consultants. Landlord's approval of
contractors for Tenant's Work Installations, which may not be unreasonably
withheld, conditioned or delayed, shall be based upon considerations such as
whether the contractor is properly licensed, his financial condition, experience
and past job performance. Upon the request of Tenant, Landlord shall grant to
Tenant and its contractors non-exclusive access to the Leased Premises (the
"Non-Exclusive Access Period") (a) during construction of Landlord's Work, upon
ten (10) days' prior oral or written advice to Tenant, at such times and for
such periods as reasonably necessary for the orderly and efficient delivery,
construction and installation of Tenant's Installations and (b) during the
thirty-day (30) period immediately prior to the anticipated date on which the
Leased Premises shall be ready for Tenant's occupancy, at reasonable times, for
the purpose of installing the Tenant's Work or Installations, provided, however,
that the installation of Tenant's Installations and Tenant's Work does not
interfere with or delay the work of General Contractor and General Contractor's
Subcontractors. General Contractor and Tenant shall use reasonable efforts to
coordinate the Tenant's Installations and Tenant's Work with Landlord's Work
during the Non-Exclusive Access Period. General Contractor shall lock the
Building and Leased Premises during the Non-Exclusive Access Period, when work
is not being performed. Tenant's access hereunder shall be at Tenant's sole risk
and expense. Commencing on the first day of the Non-Exclusive Early Access
Period, Tenant agrees that all the terms and provisions of the Lease shall be in
full force and effect except that Tenant shall have no obligation to pay rent
during the Non-Exclusive Early Access Period unless the Non-Exclusive Early
Access Period goes beyond October 31, 1999. Tenant agrees to indemnify and hold
harmless Landlord for any damage or personal injury which may occur as a result
of Tenant's entry into the Leased Premises prior to the Commencement Date.
Tenant shall deliver to Landlord evidence of the insurance required to be
maintained by Tenant pursuant to Section IV.E of the Lease prior to Tenant's
entry into the Leased Premises.

         7.       DISCLAIMER OF LIABILITY. Landlord and Tenant shall be as fully
responsible to the other for the acts and omissions of a Contractor,
Subcontractor or a Sub-subcontractor, materialman or supplier, and of the
persons employed by a subcontractor, sub-subcontractor, materialman or supplier,
and of the persons for whose acts and omissions they may be liable, as he is for
the acts and omissions of his own employees in connection with all matters
relating to this TI Agreement and the construction of the Tenant Improvements.

         8.       COST RESPONSIBILITIES.

                  (a)      LANDLORD'S COSTS: Landlord has paid all costs and
expenses relating to construction of the Base Building in accordance with the
Base Building Plans. Landlord warrants that the amounts which shall be paid out
of the Tenant Construction Allowance (and any additional amount Tenant has
agreed to pay in writing in accordance with this TI Agreement and the Lease) to
Landlord and the General Contractor and its subcontractors shall be the exact
amounts set forth in

                                                               - 6 -
<PAGE>

the bids for which contracts, as may be amended, were awarded, plus the amount
set forth in the General Contractor's contract for General Contractor's fees and
general conditions fee.

                  (b)      TENANT'S COSTS: In connection with construction of
the Tenant Improvements, Tenant hereby acknowledges its obligation to contribute
to the Leased Premises Cost as outlined in Section I.B.2 of the Lease.

         9.       CHANGE ORDERS. Tenant may authorize changes to the Tenant
Improvements during construction only by written instructions to Landlord's
Representative on a form approved by Landlord. All such changes will be subject
to Landlord's prior written approval in accordance with paragraph 4. Prior to
commencing any change, Landlord will prepare and deliver to Tenant, for Tenant's
approval, a change order setting forth the total cost of such change, which will
include associated architectural, engineering, construction contractor's costs
and fees and completion schedule changes. If Tenant fails to approve such change
order in writing within five (5) business days after delivery by Landlord,
Tenant will be deemed to have withdrawn the proposed change and Landlord will
not proceed to perform the change. Upon Landlord's receipt of Tenant's approval,
Landlord will proceed with the change. Landlord shall not be authorized to issue
change orders without the approval of Tenant in accordance with the procedures
established by this TI Agreement. Change orders to correct defects or errors in
the Base Building not caused by Tenant or Tenant's Architect, contractors,
subcontractors, employees or agents shall not be charged to Tenant or charged
against or deducted from the Tenant Construction Allowance.

         10.      COMPLETION. Time is of the essence with respect to Landlord's
and Tenant's obligations under this TI Agreement, subject, however, to the
provisions of Section X.N. of the Lease.

         11.      CONFIRMATION UPON COMPLETION. Upon completion of the Tenant
Improvements in accordance with this TI Agreement, Tenant shall confirm its
acceptance of the Leased Premises and such other matters as Landlord shall
reasonably request in accordance with Section II.D. of the Lease.

                  [remainder of page intentionally left blank]

                                      - 7 -
<PAGE>

         12.      LEASE COMMENCEMENT. Notwithstanding anything herein to the
contrary, the Commencement Date of the Lease shall be the earlier of (i) the
date Landlord has substantially completed Landlord's Work or (ii) November 1,
1999.

                                    LANDLORD:

                                    MOR BENNINGTON LLLP

                                    By: RA & FM, Inc., General Partner

                                             By: /s/ Alton D. Fryer
                                             Name: Alton D. Fryer
                                                   --------------
                                             Title: Vice President
                                                    --------------

                                    TENANT:

                                    GENVEC, INC.

                                    By: /s/ Jeffrey W. Church
                                    Name: Jeffrey W. Church
                                          ---------------
                                    Title: CFO
                                           ---

                                      - 8 -
<PAGE>

                                   EXHIBIT D-2

                                TENANT DEADLINES

Deliver Air Handler Unit
         Specifications to Landlord                                    04/21/99

Deliver Underground
         Plumbing Plans to Landlord                                    05/03/99

Approve Letting Mechanical Contract                                    05/03/99

Deliver Casework, Boilers/Pump
         Specifications to Landlord                                    05/03/99

Deliver Steel Platform Specifications
         to Landlord                                                   05/10/99

Approve Letting Casework Contract                                      05/17/99

Deliver Roof Structure Specifications
         to Landlord                                                   05/17/99

Approve Letting Roof Structure and Steel
         Platform Contracts                                            05/24/99

Deliver VAV Specifications to Landlord                                 05/28/99

Deliver Concrete/Foundation Plans to
         Landlord                                                      06/01/99

Approve Letting Concrete/Foundation
         Contract                                                      06/07/99

Approve Letting VAV Supplier Contract                                  06/07/99

Submit Permit Application, including
         Plans & Specifications to
         City of Gaithersburg                                          06/07/99

Deliver Final Plans and
         Specifications for all remaining
         Tenant Improvements to Landlord                               06/24/99

Approve Balance of Bidders List                                        06/24/99

Deliver Building Permit and all
         other applicable permits or approvals
         to General Contractor and Landlord                            07/05/99

Approve Letting Balance of Contracts                                   07/16/99

<PAGE>

                                   EXHIBIT D-3

                              CONSTRUCTION SCHEDULE

<PAGE>

                                   Exhibit D-3
                              Construction Schedule

                                [EXHIBIT OMITTED]

<PAGE>

                                   EXHIBIT D-4

                              NON-BINDING ESTIMATE

<PAGE>

<TABLE>
<CAPTION>

                        EXHIBIT D-4 NON-BINDING ESTIMATE

         4/22/99

[Pricing based on schematic plans & narrative spec. dated 2/2/99] as value engineered on or about 4-14-99

                                                                                   (42,900 Not Rentable SF)
<S>                                         <C>                                    <C>                    <C>
                                                                                                          Page 1
DIV./SECTION                                DESCRIPTION                            BIDDERS                VE BIDS VE COST/SF

01000-GENERAL REQUIREMENTS                                                         Manskin                $114,000.00
02000-SITEWORK
     02070-SELECTIVE DEMO.
     (by each trade)
03000-CONCRETE                                                                     Precision              $68,217.00

04000-MASONRY
     04200-UNIT MASONRY
     (Inc. footings)                                                               A & A Masonry          $28,681.00

05000-METALS
     05100 & 05500-STRUCTURAL
     METAL FRAMING & METAL
     FABRICATIONS                                                                  AFW                    $71,500.00

06000-WOOD & PLASTIC
     06100-ROUGH CARPENTRY
     (by each trade)                                                               Allowance              $25,790.00

     06402-INT ARCH.W.WORK: P-LAM                                                  Summit                 $11,584.00

07000-THERMAL AND MOIS-
TURE PROTECTION
     07200-INSULATION
     (by drywall trade)
     07511 & 07700-BUILT-UP ASPHALT
     ROOFING & ROOFING
     SPECIALITIES                                                                  Orndorl & Spal         $40,000.00

     07900-JOINT SEALERS                                                           Belbway                $12,271.05

08000-DOORS & WINDOWS
     08110, 08211, 08700-STEEL
     DOORS & FRAMES, FLUSH
     WOOD DOORS & FINISH
     HARDWARE                                                                      Summit                 $212,129.00

     08350-Accordian Doors                                                         MDE                    $14,600.00

     08800-GLASS & GLAZING                                                         G&A Concepts           $38,845.00

09000-FINISHES
     09250 & 09621-DRYWALL
     & ACCOUSTICAL                                                                 Summit                 $226,067.00

     09300-TILE                                                                    Willema                $14,669.00

     09650 & 09660-RESIL-
     ENT FLOOR & CARPET                                                            Share                  $58,700.00

     09800 & 09660-SPECIAL
     COATINGS & RESINOUS
     FLOORING                                                                      Life Sciences          $34,584.00

     09900 & 09950-PAINTING
     & WALLCOVERING                                                                Quality                $77,209.00

     10200-LOUVERS & VENTS                                                         Allowance              $2,700.00

     10260-CORNER GUARDS (VINYL FOR EXEC. OFFICES: 30 PCS.)                        Allowance              $420.00

     SANIRAILS                                                                     Life Sciences          $8,864.10

<PAGE>

                        EXHIBIT D-4 NON-BINDING ESTIMATE

         10600-LOCKERS                                                             Harriton               $1,920.00

         10160 & 10800-TOILET
         PARTITIONS & WASH-
         ROOM ACCESS                                                               Summit                 $8,568.00

         11470-DARKROOM DOOR                                                       Allowance              $850.00

12000-FURNISHINGS
         12345-LABORATORY
         CASEWORK                                           (Mid-Atlantic)         Thoma, Inc.            $330,000.00

         12510-BLINDS
         12570-RUGS & MATS                                                         Matworks               $2,100.00

13000-SPECIAL CON-
         STRUCTION
         13038-COLD ROOMS                                                          Allowance              $31,202.26

15000-MECHANICAL
         15300-Fire Protection                                                     Chesapeake             $57,575.00
         15400-Plumbing                                                            Heffron                $2,688,132.00
         15500-HVAC

16000-ELECTRICAL                                                                   Trunnell               $604,338.00

                                                                                   Subtotal:              $4,753,415.41
                                                                                   Fee:                   $239,170.77

                                                                                   Total:                 $5,022,586.18 $132.17
</TABLE>
<PAGE>

                                    EXHIBIT E

                          LEASE COMMENCEMENT AGREEMENT

THIS LEASE COMMENCEMENT AGREEMENT, made this ___ day of ___________, 1999, by
and between MOR BENNINGTON LLLP ("Landlord") and GENVEC, INC. ("Tenant").

WITNESSETH:

WHEREAS, Landlord and Tenant have entered into that certain Lease Agreement
dated _______________________, 1999, (the "Lease") for the premises located at
65 West Watkins Mill Road, Gaithersburg, Maryland 20879 (the "Leased Premises");
and

WHEREAS, Landlord and Tenant wish to set forth their agreements as to the term
of the Lease, as well as certain other matters, all as more particularly set
forth below.

NOW, THEREFORE, in consideration of the Leased Premises as described in the
Lease and the covenants set forth therein, Landlord and Tenant agree as follows:

         1.       The "Commencement Date" for all purposes of the Lease is
___________________, 1999.

         2.       The initial Lease Term shall expire on ______________________,
201_.

         3.       The Deposit was received from Tenant by Landlord in the amount
of $51,837.50 which shall be applied in accordance with Paragraph III.A. of the
Lease.

         4.       [OTHER PROVISIONS, if any.]

<PAGE>

                                    EXHIBIT F

                              RULES AND REGULATIONS

         1. Neither Tenant nor any of its servants, agents, invitees, employees
and/or licensees will park on, store on or otherwise utilize any parking or
loading areas on the Property except as shown on EXHIBIT A, and then only in the
parking places designated by Landlord. Such parking must be in accordance with
the rules and regulations Landlord may promulgate from time to time with respect
to parking.

         2. Tenant will not pile, place or permit to be placed any goods,
materials, equipment or other obstructions on the sidewalks or parking lots in
the front, rear or sides of the Building, or in a place and in a manner so as to
block the sidewalks, parking lots and loading areas. Tenant will not do anything
that directly or indirectly takes away any of the rights of ingress, egress or
natural light from any other tenant in the Building.

         3. Tenant will not inscribe, paint, affix or otherwise display signs,
decals, advertisements or notices visible from outside the Leased Premises in,
on, upon or behind any windows or on any door, partition or other part of the
interior or exterior of the Building. Tenant will not attach or place awnings,
antennas or other projections on the outside walls on any exterior portion of
the Building. Any such exterior projections attached or placed without
Landlord's prior written consent will be subject to removal at any time, without
notice, at Tenant's sole expense. No curtains, blinds, shades or screens will be
attached to, hung in or used in connection with any window or door of the Leased
Premises unless previously approved by Landlord or shown on EXHIBIT B.

         4. The delivery, shipping, loading and unloading of goods, wares,
merchandise, equipment, supplies, fixtures and all other items to and from the
Leased Premises will be subject to the rules and regulations Landlord may
promulgate from time to time with respect to deliveries and shipments.

         5. All garbage and refuse will be kept in the kind of container
specified by Landlord, and will be placed outside of the Building for collection
in the manner, in such containers or dumpsters and at the times and places
reasonably specified by Landlord. Tenant will not burn any trash or garbage of
any kind in or around the Leased Premises. Tenant shall contract directly with a
private waste removal company, reasonably acceptable to Landlord, for removal of
all trash, garbage or refuse from the Leased Premises and its exterior
dumpsters.

         6. No radio, speakers, television, phonograph or other sound or similar
device will be installed or operated in the Leased Premises without Landlord's
prior written approval. Tenant will prevent sounds emanating from the Leased
Premises from being heard outside the Leased Premises or otherwise unreasonably
disturbing or annoying other tenants.

         7. The plumbing facilities will not be used for any purpose other than
that for which they are constructed. No foreign substance of any kind will be
thrown into the plumbing facilities. The expense of any breakage, stoppage or
damage resulting from a violation of this provision by Tenant or any of its
servants, agents, invitees, employees and/or licensees will be borne solely by
Tenant.

<PAGE>

         8. Tenant will not place a load upon the floor of the Leased Premises
exceeding the floor load per square foot area which the floor of the Leased
Premises has been designed to carry.

         9. Tenant will not use the Leased Premises for the sale of any goods,
wares or merchandise. Tenant will not permit anyone to lodge or sleep in the
Leased Premises. Tenant is responsible for all persons whom it invites and/or
admits to the Leased Premises and will be liable to Landlord for all acts of
such persons.

                                       F-2
<PAGE>

                                    EXHIBIT G

                         SPECIALIZED TENANT IMPROVEMENTS

A.       Animal Facility

                  1        Cage washer (manufacturer is Castle 8666)
                  1        Autoclave, cage (manufacturer is Getinge)
                  4        Animal racks

B.       Glasswash Equipment

                  1        Autoclave, clean steam (manufacturer is Castle)
                  1        Glasswasher (manufacturer is Castle)

C.       5        DI Polishers, water system (manufacturer is U.S. Filter)

D.       Building furnishings

                  See attached list of furniture and equipment

E.       Telephone voice mail system

                  Manufacturer ___________________ (model number or other
identification ________)

F.       Uninterrupted power supply (UPS) system

G.       Removable building mechanical systems (no piping will be removed)

                  -        steam boiler
                  -        lab air compressors
                  -        vacuum pump
                  -        RO DI water systems
                  -        Emergency generator

H.       Lockers

I.       Prefab cold room kits

<PAGE>

<TABLE>
<CAPTION>

                              EXHIBIT G (continued)

                      Cost Model - Furniture and Equipment

         Category                              Description     Units                       Cost/Unit      Subtotal        Total
<S>                                            <C>                                         <C>            <C>          <C>
Fixtures, Furniture, Equipment                 Office Furniture Systems
                                               Open Work Stations
                                                            64 Work Station*                    29        $4,000       $116,000
                                                                    Carols**                    17        $1,000       $17,000
                                                              File Pedestals                    16        $210         $3,360
                                                                                                                       $136,360
                                               Private Office
                                                                        Desk                    6         $600         $3,600
                                                                    Credenza                    6         $600         $3,600
                                                                       Hutch                    6         $600         $3,600
                                                   Bookcase/File cabinet***                     6         $800         $4,800
                                                                                                                       $15,600
                                               Lobby
                                                        Receptionist Station                    1         $6,000       $6,000
                                                                 Lobby Table                    1         300          $300
                                                                 Lobby Chair                    2         $700         $1,400
                                                                                                                       $7,700
                                               Conference Room
                                                             Conf Room Table                    3         2500         $7,500
                                                     Conf Room Table - Large                    1         6000         $6,000
                                                    Conf Room Table 36 Round                    2         175          $350
                                                  Conf Room Table - 42 Round                    1         250          $250
                                                  Conf Room Table - 48 Round                    1         275          $275
                                                      Conference Room Chairs                    54        250          $13,500
                                                                                                                       $27,875
                                               Cafeteria
                                                     Cafeteria/Lounge Tables                    7         200          $1,400
                                                        Cafeteria Chairs****                    22        $150         $3,300
                                                                                                                       $4,700
                                               Accessories
                                                       White Board - cabinet                    4         $1,500       $6,000
                                                       White board, Aluminum                    6         $100         $600
                                                     Projection Screens*****                    4         $200         $800
                                                                                                                       $7,400
                                               File cabinets
                                                            5-Drawer Lateral                    5         $400         $2,000
                                                                                                                       $2,000
                                               Office Chairs
                                                            Executive Chairs                    23        $400         $9,200
                                                                Guest Chairs                    23        $200         $4,600
                                                   Work Station Chairs******                    46        $275         $12,650
                                                                                                                       $26,450
                                               Laboratory Chairs                                30        $250         $7,500
                                                                                                                       $7,500
                                               Computer Equipment
                                                      Network Hubs & Routers                    1         $30,000      $30,000
                                               Computer Room Racks/Fixtures                     1         $7,000       $7,000

* Includes production room workstation                                                                                 $37,000
** Includes computer workstation carols in library
*** Priced for 5 drawer lateral. Bookcase approx. $400                                                                 $272,585
**** Includes 2 chairs in lounge
*****Price is for standard, non electrical projection screens.
******* Includes 3 chairs at library tables, but not computer chairs
</TABLE>
<PAGE>

                                    EXHIBIT H

                       MINIMUM CONTRACT SPECIFICATIONS FOR
                                   HVAC SYSTEM
                            PREVENTATIVE MAINTENANCE
                                       AND
                         FULL PARTS AND LABOR SERVICING

I.       FULL PARTS & LABOR

         A.       This contract is meant to be a full parts and labor contract
                  on the installed equipment as detailed on a separate sheet. It
                  includes all repairs resulting from malfunctions discovered
                  during inspections and emergency service requests.

         B.       Components under this agreement that may be obsolete will be
                  repaired until such time as they are no longer repairable and
                  the equipment must be replaced.

II.      QUARTERLY INSPECTIONS SHALL BE PROVIDED AS FOLLOWS:

         A.       General: Performed at all quarterly inspections

                  1.       Replace all filters as required
                  2.       Lubricate all motors and bearings
                  3.       Adjust and/or replace all fan belts
                  4.       Clean grilles, etc., as required

         B.       Spring and Summer:

                  1.       Check refrigerant charge and/or temperature
                           difference across evaporator coil
                  2.       Check refrigerant piping for leaks with electronic
                           leak detector
                  3.       Check all operating and safety controls for cooling
                  4.       Check system operation - (operating pressures, super
                           heat, compressor running current, condensate removal,
                           etc.)
                  5.       Clean condenser and/or evaporator coil as required
                  6.       Check and tighten all electrical connections at unit
                           as required

         C.       Fall and Winter:

                  1.       Check system operation - (operating pressures, etc.)
                  2.       Check all operating and safety controls for heating
                  3.       Check and tighten all electrical connections at unit
                           as required

III.     QUALIFICATIONS OF CONTRACTORS

         All contractors providing the services described above shall be
         qualified and certified by an EPA-approved testing organization to work
         with refrigerants and other chemicals.

<PAGE>

                                    EXHIBIT I

                          CERTIFICATION OF HVAC SYSTEM

                              BY LICENSED MECHANIC

65 West Watkins Mill Road
Gaithersburg, Maryland 20879

TO WHOM IT MAY CONCERN:

The heating and cooling equipment which conditions the air in the subject space
has been thoroughly inspected. All necessary repairs, replacements, and services
have been performed to insure that the system operates properly in the following
aspects:

         1.       All electrical circuitry and all components function properly.

         2.       Refrigerant charge is correct.

         3.       Evaporator and condenser coils are clean.

         4.       Belts are in good condition and all new filters installed.

         5.       All bearings are in good order and properly greased.

         6.       All wiring is in order and properly secured.

         7.       All access panels are in place.

         8.       All air diffusers include operational dampering devices.

         9.       All oil-heating appliances are clean and properly adjusted.

         10.      Components requiring clear and unobstructed condition for
                  proper operation are in order.

         11.      All safety devices are operational.

         12.      Thermostats are operational, calibrated, and in proper
                  condition.

                                    NAME OF CERTIFYING CONTRACTOR:

                                    By: (NAME OF COMPANY
                                    REPRESENTATIVE):

                                    LICENSE NO.:

                                    DATE OF CERTIFICATION:

<PAGE>

                                    EXHIBIT J

                         PERMITTED HAZARDOUS SUBSTANCES

GenVec has four classes of hazardous materials on-site.

1.       Hazardous Chemicals and Hazardous Chemical Waste. GenVec uses a variety
         of hazardous chemicals in fairly small quantities as demonstrated by
         the attached chemical inventory. In addition, GenVec generates a
         quantities of hazardous chemical wastes typical of most biotech firms,
         which are shipped off-site by a licensed carrier within 180 days of
         generation. The majority of the waste generated includes:

         (a) Silver Stain waste consisting of glutaraldehyde, silver nitrate,
         and formaldehyde
         (b) Organic waste in the form of acetonitrile and trifluoroacetic acid,
         (c) Mixed alcohols, and
         (d) Small individual quantities of phenol, glutaraldehyde, freon,
             acetonitrile, ethidium bromide, and acrylamide.

         All chemicals and chemical wastes shall be handled, stored and disposed
         of in strict accordance with all applicable state and Federal
         regulations, including but not limited to OSHA requirements.

2.       Radioactive Isotopes and Radioactive Material

         GenVec uses and generates low levels of radioactive materials using the
         following isotopes: 32P, 3H, 35S, 125I, and 51Cr.

         All radioactive materials shall be handled, stored, and disposed of in
         strict accordance with all applicable state and Federal regulations,
         including but not limited to OSHA requirements.

3.       Biohazards

         GenVec uses biohazards such as human cell lines, wild-type and
         recombinant viruses (such as adenovirus), bacteria, and others. In
         addition, GenVec will be generating animal waste. All biohazards used
         at GenVec will be those classified as BSL 1 or 2. No BSL 3 or BSL 4
         work will be performed at or brought onto the Leased Premises.

         All biohazards shall be handled, stored, and disposed of in strict
         accordance with all applicable state and Federal regulations, including
         but not limited to OSHA requirements.

4.       Compressed Gasses

         GenVec uses a variety of compressed gasses including CO2, nitrogen,
oxygen, compressed air, argon and argon mixtures.

         All cylinders shall be handled, stored and disposed of in strict
         accordance with all applicable state and Federal regulations, including
         but not limited to OSHA requirements.

Prior to commencing its use of any of the above permitted Hazardous Substance,
GenVec will provide Landlord with its chemical hygiene plan (the "CHP") which
shall meet or exceed the OSHA general industry standards set forth in 29 CFR
1910.1450, including Appendix A thereof, and its use, handling, storage and
disposal of any approved Hazardous Substances shall be done at all times in
strict compliance with the CHP.

<PAGE>

<TABLE>
<CAPTION>

GENVEC
CHEMICAL INVENTORY
                                                                                                                      GENVEC
                                                                                                        12111 PARKLAWN DRIVE
                                                                                                         ROCKVILLE, MD 20852

COMMON NAME                             HAZARD                               LOCATION        QUANTITY    CONTAINER SIZE/TYPE
-----------                             ------                               --------        --------    -------------------
<S>                                   <C>                                    <C>             <C>         <C>

1-DEOXYMANNOJIRIMYCIN                 HARMFUL                                LAB                 1        50 G BOTTLE
1,1,2 TRICHLORO 1,2,2                 HARMFUL                                CHEM                5        500 ML BOTTLE
2, MERCAPTOETHANOL                    POISON                                 REF,M5              2        250 ML BOTTLE
2-METHYL-1-PROPANOL                   HARMFUL                                CHEM ROOM           1        250 ML BOTTLE
3-AMINO-1,2,4-TRIAZOLE                TOXIC                                  L4                  1        100G
32p Gamma ATP                         RADIOACTIVE                            M5                  1
32-P dCTP (1 MC)                      RADIOACTIVE                            M5                  1
32P ATP                               RADIOACTIVE                            M5                  1
32P UTP                               RADIOACTIVE                            M5                  1
35S ATP                               RADIOACTIVE                            M5                  2
35S METHIONIONE                       RADIOACTIVE                            RAD ROOM            1        500 MCI
3H THYMADINE                          RADIOACTIVE                            M5                  2
5-BROMO-2-DEOXY-URIDINE               POISON                                 MAIN LAB            4
8-METHYLOXY PSORALEN                  POISON                                 LAB                 1        1 G CAN
ACETIC ACID, GLACIAL                  CORROSIVE                              LAB                 2        2.5 L BOTTLE
ACETONE                               FLAMMABLE, HARMFUL                     Chem Room           1        4 L Bottle
ACETONE                               FLAMMABLE                              CHEM ROOM           1        4L
ACETONITRILE                          FLAMMABLE                              CHEM ROOM           1        1L BOTTLE
ACETONITRILE UV                       FLAMMABLE                              CHEM ROOM           19       1L BOTTLE
ACIDASE PEPTONE                       HARMFUL                                CHEM ROOM           1        250 BOTTLE
ACRIDINE ORANGE                       HARMFUL                                CHEM ROOM           1        10G BOTTLE
ACRYL BIS (ACRILIMIDE)                HARMFUL, EYE IRRITATION,               CHEM ROOM           8        40 G
                                      NERVE
ACRYLAGEL                             HARMFUL                                CHEM ROOM           2        1L BOTTLE
ALCOHOL                               HARMFUL/FLAMMABLE                      CHEM ROOM           6        4L BOTTLE
ALCOHOL, ANHYDROUS                    FLAMMABLE                              CHEM ROOM           6        4L
REAGENT
ALCOHOL, REAG                         HARMFUL/FLAMMABLE                      CHEM ROOM           2        500 ML BOTTLE
AMMONIA CHLORIDE                      HARMFUL                                CHEM ROOM           1        500 G
AMMONIUM ACETATE                      IRRITANT                               CHEM ROOM           3        500 G BOTTLE

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                      GENVEC
                                                                                                        12111 PARKLAWN DRIVE
                                                                                                         ROCKVILLE, MD 20852

COMMON NAME                                 HAZARD                           LOCATION       QUANTITY     CONTAINER SIZE/TYPE
-----------                                 ------                           --------       --------     -------------------

AMMONIUM CHLORIDE                           HARMFUL                          CHEM ROOM           1       500G BOTTLE
AMMONIUM HYDROXIDE                          SEVERE HEALTH HAZARD             CHEM ROOM           1       500 ML BOTTLE
AMMONIUM PERSULFATE ULTRA PURE              STRONG OXIDIZING AGENT.LAB                           1       100G BOTTLE
AMMONIUM SULFATE                            HARMFUL                          CHEM ROOM           1       5 KG CAN
APROTININ                                   HARMFUL                          M5 REF              3       10 MG
BIOTINYLATED SDS MOLECULAR                  IRRITANT                         L5                  1       1 KIT
Bis-acrylgel                                HARMFUL                          CHEM ROOM           3       450 ML BOTTLE
BISBENZIMIDE                                HARMFUL                          L5                  1       25MG
BORIC ACID                                  MODERATE HEALTH HAZARD           CHEM ROOM           2       500G & 2.5 KG BOTTLE
BUTYL ALCOHOL                               FLAMMABLE                        CHEM ROOM           1       500ML & 4L BOTTLE
CADIUM CHLORIDE                             HIGHLY TOXIC                     CHEM ROOM           1       100 G BOTTLE
CALCIUM CARBONATE                           NUSIANCE DUST                    CHEM ROOM           1       500 G BOTTLE
CALCIUM CHLORIDE                            IRRITANT                         CHEM ROOM           2       2.5 KG BOTTLE
CESIUM CHLORIDE                                                              CHEM ROOM           3       2 KG BOTTLE
CHES                                        IRRITANT                         CHEM ROOM           1       25 G BOTTLE
CHLORAMPHENICOL                             TOXIC                            CHEM ROOM           1       25 G BOTTLE
CHLOROFORM                                  POISON                           CHEM ROOM           4       M5-500 ML BOTTLE
CHLOROQUINE                                 POISON                           CHEM ROOM           3       50G & 1G BOTTLE
CHLOROTRIMETHYLSILANE                       CORROSIVE                        CHEM ROOM           1       5 G BOTTLE
CHROMIUM 51                                 RADIOACTIVE                      M5                  1
CITRIC ACID                                 IRRITANT                         CHEM ROOM           1       100G BOTTLE
COLCHINE                                    POISON                           CHEM ROOM           1       1 G BOTTLE
COOMASSIE BLUE                              HARMFUL                          CHEM ROOM           1       25 G BOTTLE
CUPROUS CHLORIDE                            TOXIC                            CHEM ROOM           1       100G BOTTLE
CYANOGEN BROMIDE                            POISON                           CHEM ROOM           1       L4-100 G BOX
DEOXYCHOLIC ACID                            HARMFUL                          CHEM ROOM           4       100G BOTTLE
DEOXYMANNO JIRIMYCIN                        HARMFUL                          MAIN LAB            1       BOTTLE
DEXAMETHASONE                               HARMFUL                          M4                  1       100 MG BOTTLE

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                     GENVEC
                                                                                                       12111 PARKLAWN DRIVE
                                                                                                        ROCKVILLE, MD 20852

COMMON NAME                             HAZARD                               LOCATION        QUANTITY   CONTAINER SIZE/TYPE
-----------                             ------                               --------        --------   -------------------

DEXTRAN SULFATE                                                              CHEM ROOM           1      100 G BOTTLE
DIETHANOLAMINE                         HARMFUL                               CHEM ROOM           1      500 ML BOTTLE
DIETHYL PIROCARBONATE                  POISON                                MOL BIO LAB         2      5 ML BOTTLE
(DEPC)
DIGITONIN                              HIGHTLY TOXIC                         CHEM ROOM           2      5G CANISTER
DIMETHYL FORMAMIDE                     TOXIC, CORROSIVE                      CHEM ROOM           1      1L BOTTLE
DIMETHYL SULFOXIDE                     HARMFUL, IRRITANT                     CHEM ROOM           2/1    100 ML/1L BOTTLE
DIMETHYLDIOCTADECYL-                   IRRITANT                              CHEM ROOM           1      10 G BOTTLE
AMMONIUM
DITHIOTHREITOL (DTT)                   HIGHLY TOXIC                          L4                  1      5 G BOTTLE
DOIUM PHOSPHAGE DIBASIC                IRRITANT                              CHEM ROOM           2      2.5 KG BOTTLE
EN'HANCE                               FLAMMABLE                             CHEM ROOM           1      1L
ETHIDIUM BROMIDE                       TOXIC                                                     2      1G
FERRIC SULFATE                         HARMFUL                               CHEM ROOM           1      500 ML BOTTLE
FIXER                                  IRRITANT                              DARK ROOM           8      1 GAL BOTTLE
FIXER & REPLENISHER                    IRRITANT                              DARK ROOM           8      13.8 L BOTTLE
FORMALDEHYDE, 1.3M                     POISON/FLAMMAGLE                      CHEM ROOM           8      500 ML
(PARAFIX)
FORMAMIDE                              HARMFUL                               CHEM ROOM           3      M4-500 ML BOTTLE, L4-500 ML
FORMIC ACID                            HARMFUL                               CHEM ROOM           1
GUANIDINE HCI                          HARMFUL                               CHEM ROOM           2      500 G BOTTLE
(HYDROCHLORIDE)
GUANIDINE THIOCYINATE                  IRRITANT                              CHEM ROOM           1      500 G BOTTLE
HEPES BUFFER SOLUTION                  IRRITANT                              CHEM ROOM           4      250 G BOTTLE
HYDROCHLORIC ACID                      POISON, CORROSIVE                     CHEM ROOMR          3      2.5 L BOTTLE
HYDROCORTISONE                         HARMFUL, IRREVERSIBLE                 CHEM ROOM           1      5 G BOTTLE
                                       EFFECTS,
HYDROXYLAMINE                          CORROSIVE                             CHEM ROOM           1      500 G BOTTLE
HYDROXYQINONE                          IRRITANT                              CHEM ROOM           1      500 G BOTTLE
Hygromycin B Hydrochloride             POISON                                M5                  1      50 MG BOTTLE
IGEPAL CA-630                          HARMFUL                                                   1      100ML
IMIDAZOLE                              CORROSIVE                             CHEM ROOM           1      100 G BOTTLE
ISOPENTYL ALCOHOL                      COMBUSTIBLE/HARMFUL                   CHEM ROOM           6      500 ML BOTTLE

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                     GENVEC
                                                                                                       12111 PARKLAWN DRIVE
                                                                                                        ROCKVILLE, MD 20852

COMMON NAME                            HAZARD                                LOCATION     QUANTITY      CONTAINER SIZE/TYPE
-----------                            ------                                --------     --------      -------------------

ISOPROPYL ALCOHOL                      FLAMMABLE, AFFECTS CNS,               CHEM ROOM       8          M4-1L BOTTLE, L4-1L BOTTLE
ISOPROPYL ALCOHOL                      COMBUSTIBLE/HARMFUL                   CHEM ROOM       3          4 L BOTTLE
LAURYL SULFATE                         HARMFUL                               CHEM ROOM       1          250 ML BOTTLE
LEUPEPIN                               HARMFUL                               M5              3          5 MG CANISTERS
LITHIUM ACETATE                        HARMFUL                               CHEM ROOM       1          250 G BOTTLE
LITHIUM CHLORIDE                       HARMFUL                               CHEM ROOM       3          500 G BOTTLE
M-CRESOL                                                                     CHEM ROOM       1          CANISTER
MAGNESIUM ACETATE                      HARMFUL                               CHEM ROOM       1          250 BOTTLE
MAGNESIUM CHLORIDE (M)                 HARMFUL                               CHEM ROOM       1          2.5 KG BOTTLE
#7791
MANGANESE CHLORIDE                     HARMFUL                               CHEM ROOM       1          500 G BOTTLE
MANGNESIUM SULFATE                     HARMFUL                               CHEM ROOM       1          500 G BOTTLE
MES                                    HARMFUL                               CHEM ROOM       1          25 G BOTTLE & 500 G BOTTLE
METHANOL                               POISON, FLAMMABLE                     CHEM ROOM       5          4 L BOTTLE
METHANOL                               POISON, FLAMMABLE                     CHEM ROOM       5          4L BOTTLE
METHIONINE                             COMBUSTIBLE DUST                      CHEM ROOM       1          100G BOTTLE
[METHYL-3H] THYMIDINE                  RADIOACTIVE                           M4              3          5ML
MONENSIN SODIUM                        POISON                                L5              1          500 MG BOTTLE
MONOETHANOLAMINE                       FLAMMABLE/CHEMICAL                    CHEM ROOM       1          500ML BOTTLE
MOPS                                   IRRITANT                              CHEM ROOM       1          500 G BOTTLE
MTT                                    TOXIC                                 CHEM ROOM       1          500 MG BOTTLE
N-(1-NAPHTHYL)                         IRRITANT                              MOL BIO         1          25 G BOTTLE
ETHYLENDIAMINE
N,N-DIMETHYL FORMAMIDE                 POISON                                CHEM ROOM       2          100 ML BOTTLE
N-ACETYL LACTOSE AMINE                 POISON                                L4              1          25 MG BOTTLE
N-BUTYL ALCOHOL                        FLAMMABLE                             CHEM ROOM       2          1 LITER BOTTLE
N-SUCCINIMIDYL PROPIONATE              RADIOACTIVE                           L4              1          1ML
NICKEL SULFATE AR                      HARMFUL                               CHEM ROOM       1          125 G BOTTLE
NONIDATE                               IRRITANT                              CHEM ROOM       2          100 ML BOTTLE
OKADAIC ACID                           TOXIC                                 L5              1          25KG

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                     GENVEC
                                                                                                       12111 PARKLAWN DRIVE
                                                                                                        ROCKVILLE, MD 20852

COMMON NAME                            HAZARD                                LOCATION       QUANTITY    CONTAINER SIZE/TYPE
-----------                            ------                                --------       --------    -------------------

PARAFORMALDEHYDE                       HARMFUL                               CHEM ROOM         1        500G BOTTLE
PHENOL                                 POISON, CAUSTIC, ANALGESIC            M4                4        500 G BOTTLE
PHENYL                                 HARMFUL                               CHEM ROOM         1        500 GRAM BOTTLE; 100 G
PHOSPHATASE                            CORROSIVE                             CHEM ROOM         1
PHOSPHORIC ACID,                       CORROSIVE                             CHEM ROOM,        1        2.5 KG BOTTLE
ACS REAGENT
PIPES                                  IRRITANT                              CHEM ROOM         2        100G BOTTLE
POLYOXYETHYLENE SORBITAN               HARMFUL                                                 1        100ML
POLYVINYL-POLYPYRROLIDONE              HARMFUL                               CHEM ROOM         1        250 ML BOTTLE
PONCEAU S                              IRRITANT                              CHEM ROOM,        1        1 LITER BOTTLE
POSTASSIUM HYDROCHLORIDE               HARMFUL                               CHEM ROOM         1        2.5 KG BOTTLE
POTASSIUM ACETATE                      IRRITANT                              CHEMROOM,         3        2.5 KG BOTTLE
(CRYSTALS)
POTASSIUM BICARBONATE                  IRRITANT                              CHEM ROOM         1        250 BOTTLE
POTASSIUM CHLORIDE                     HARMFUL                               CHEM ROOM         1        2.5 KG BOTTLE
POTASSIUM FERROCYANIDE                 IRRITANT                              CHEM ROOM         2        500 G BOTTLE
POTASSIUM FERRYANIDE                   IRRITANT                              CHEM ROOM         1        500 G BOTTLE
POTASSIUM HYDROXIDE                    POISON                                CHEM ROOM         1        2.5KG
PELLETS
PROMIX 35S                             RADIOACTIVE                           RI ROOM           1
PROPANOL                               HARMFUL                               CHEM ROOM         5        1 LITER BOTTLE
PROPANOL                               HARMFUL                               CHEM ROOM         4        4 LITER BOTTLE
PROPIDIUM IODIDE                       POISON                                M5                1        10 MG BOTTLE
PROTEASE                               HARMFUL                               L4                1        250 MG BOTTLE
PROTOGEL                               HARMFUL                               CHEM ROOM         4        1L BOTTLE
PUROMYCIN                              TOXIC                                 L5                1        10MG
REDIVUE                                RADIOACTIVE                           M4                4        500 microL
RUBIDIUM CHLORIDE                      IRRITANT                              CHEM ROOM         5        100G BOTTLE
SEC-Butanol                            Highly Flammable                      CHEM ROOM         1        1 LITER BOTTLE
SILVER NITRATE                         POISON/CORROSIVE                      LAB               1        30 G BOTTLE
SODIUM ACETATE TRIHYDRATE              IRRITANT                              CHEM ROOM         2        2.5 KG BOTTLE

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                 GENVEC
                                                                                                   12111 PARKLAWN DRIVE
                                                                                                    ROCKVILLE, MD 20852

COMMON NAME                            HAZARD                              LOCATION     QUANTITY    CONTAINER SIZE/TYPE
-----------                            ------                              --------     --------    -------------------

SODIUM AZIDE                           POISON                              CHEM ROOM         1      500 G BOTTLE
SODIUM BICARBONATE                     MODERATE HAZARD                     CHEM ROOM         2      1LB & 2.5 KG BOTTLE
SODIUM BORATE                          HARMFUL                             CHEMROOM          2      2.5 KG BOTTLE
SODIUM CARBONATE                       IRRITANT                            CHEM ROOM         1      500 G BOTTLE
SODIUM CHLORIDE                        IRRITANT                            CHEM ROOM         2      5 KG BOTTLE
SODIUM CITRATE                         CONTACT HAZARD                      CHEM ROOM R       1      500 G BOTTLE
SODIUM DODECYL SULFATE                 IRRITANT                            CHEM ROOM         1      500 G BOTTLE
(SDS)
SODIUM FLUORIDE                        POISON                              CHEM ROOM         1      100G BOTTLE
SODIUM HYDROXIDE                       POISON                              CHEM ROOM         5      2.5 KG BOTTLE
SODIUM M-ARSINITE                      TOXIC                               CHEM ROOM         1      100G BOTTLE
SODIUM ORTHOVANDATE                    HARMFUL                             LAB               2      50 G BOTTLE
SODIUM PHOSPHATE DIBASIC               IRRITANT                            CHEMROOM
SODIUM PHOSPHATE MONOBASIC             IRRITANT                            CHEM ROOM         2      2.5 KG BOTTLE
SODIUM PYROPHOSPHATE                                                       CHEM ROOM         1      500G BOTTLE
SODIUM SALICYLATE                      IRRITANT                            CHEM ROOM         1      2.5 KG BOTTLE
SODIUM SULFITE                         IRRITANT                            CHEM ROOM         2      500 G BOTTLE
SODIUM THIOSULFATE                     IRRITANT                            CHEM ROOM         1      500 G BOTTLE
SPERMIDINE                             IRRITANT                            L5                1      5 G BOTTLE
SULFANILAMIDE                          HARMFUL                             MOL. BIO LAB      1      100 G BOTTLE
SULFURIC ACID                          POISON                              CHEM ROOM         1      2.5 L BOTTLE
TEMED                                  HIGHLY FLAMMABLE,                   CHEM              2/1    100 ML BOTTLE/25 ML BOTTLE
                                           CORROSIVE
TERT-BUTANOL                           FLAMMABLE/HARMFUL                   CHEM ROOM         1      500 ML BOTTLE
THIMERSOL                              TOXIC                               CHEMIROOM         1      25G BOTTLE
TRICHLORO TRIFLOUROETHANE              HARMFUL                             CHEM ROOM         13     500ML BOTTLE
TRICHLOROACETIC ACID                   CORROSIVE                           CHEMROOM          8      500 G BOTTLE
TRIETHANOLAMINE                        IRRITANT                            CHEM ROOM         1      250 G BOTTLE
TRIFLUOROACETIC ACID                   HARMFUL                             CHEM ROOM         2      450 ML BOTTLE
TRIS                                   MODERATE HEALTH HAZARD              CHEM ROOM         2/1    5 KG TUBS/1 KG BOTTLE

<PAGE>

GENVEC
CHEMICAL INVENTORY
                                                                                                                     GENVEC
                                                                                                       12111 PARKLAWN DRIVE
                                                                                                        ROCKVILLE, MD 20852

COMMON NAME                            HAZARD                              LOCATION         QUANTITY    CONTAINER SIZE/TYPE
-----------                            ------                              --------         --------    -------------------

TRIS HYDROCHLORIDE                     HARMFUL                             CHEM ROOM           1        1 KG BOTTLE
Trilon X-100                           MODERATE HEALTH HAZARD              CHEM ROOM           1        100 ML BOTTLE
TRYPSIN                                HARMFUL                             L5                  1        1G
TWEEN 20                               IRRITANT                            CHEM ROOM           2        500 ML BOTTLE
TWEEN-80                               CARCINOGEN                          CHEM ROOM           1        100 ML BOTTLE
ZINC CHLORIDE                          TOXIC/CORROSIVE                     CHEM ROOM           1        100G BOTTLE
ZINC SULFATE                           IRRITANT                            CHEM ROOM           12       100G BOTTLE

</TABLE>

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00015-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00015-of-00352.parquet"}]]