Document:

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                                                                    Exhibit 10.1

                     PREDIX PHARMACEUTICALS HOLDINGS, INC.

                 AMENDED AND RESTATED 2003 STOCK INCENTIVE PLAN

      1.    PURPOSE.

      The purpose of this Amended and Restated 2003 Stock Incentive Plan,
including Appendix A hereto (the "Plan"), of Predix Pharmaceuticals Holdings,
Inc., a Delaware corporation (the "Company"), is to advance the interests of the
Company's stockholders by enhancing the Company's ability to attract, retain and
motivate persons who make (or are expected to make) important contributions to
the Company by providing such persons with equity ownership opportunities and
performance-based incentives and thereby better aligning the interests of such
persons with those of the Company's stockholders. Except where the context
otherwise requires, the term "Company" shall include any of the Company's
present or future parent or subsidiary corporations as defined in Sections
424(e) or (f) of the Internal Revenue Code of 1986, as amended, and any
regulations promulgated thereunder (the "Code") and any other business venture
(including, without limitation, joint venture or limited liability company) in
which the Company has a controlling interest, as determined by the Board of
Directors of the Company (the "Board").

      2.    ELIGIBILITY.

      All of the Company's employees, officers, directors, consultants and
advisors are eligible to be granted options, restricted stock awards, or other
stock-based awards (each, an "Award") under the Plan; provided, however, that in
no event shall Awards with respect to more than 203,794 shares be granted to any
Participant in any fiscal year subject to adjustment under Section 8. Each
person who has been granted an Award under the Plan shall be deemed a
"Participant".

      3.    ADMINISTRATION AND DELEGATION.

            (a)   Administration by Board of Directors. The Plan will be
administered by the Board. The Board shall have authority to grant Awards and to
adopt, amend and repeal such administrative rules, guidelines and practices
relating to the Plan as it shall deem advisable. The Board may correct any
defect, supply any omission or reconcile any inconsistency in the Plan or any
Award in the manner and to the extent it shall deem expedient to carry the Plan
into effect and it shall be the sole and final judge of such expediency. All
decisions by the Board shall be made in the Board's sole discretion and shall be
final and binding on all persons having or claiming any interest in the Plan or
in any Award. No director or person acting pursuant to the authority delegated
by the Board shall be liable for any action or determination relating to or
under the Plan made in good faith.

            (b)   Appointment of Committees. To the extent permitted by
applicable law, the Board may delegate any or all of its powers under the Plan
to one or more committees or
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subcommittees of the Board (a "Committee"). All references in the Plan to the
"Board" shall mean the Board or a Committee of the Board or the executive
officers referred to in Section 3(c) to the extent that the Board's powers or
authority under the Plan have been delegated to such Committee or executive
officers.

            (c)   Delegation to Executive Officers. To the extent permitted by
applicable law, the Board may delegate to one or more executive officers of the
Company the power to grant Awards to employees or officers of the Company or any
of its present or future subsidiary corporations and to exercise such other
powers under the Plan as the Board may determine, provided that the Board shall
fix the terms of the Awards to be granted by such executive officers (including
the exercise price of such Awards, which may include a formula by which the
exercise price will be determined) and the maximum number of shares subject to
Awards that the executive officers may grant; provided further, however, that no
executive officer shall be authorized to grant Awards to any "executive officer"
of the Company (as defined by Rule 3b-7 under the Securities Exchange Act of
1934, as amended (the "Exchange Act")) or to any "officer" of the Company (as
defined by Rule 16a-1 under the Exchange Act).

      4.    STOCK AVAILABLE FOR AWARDS. Subject to adjustment under Section 8,
Awards may be made under the Plan for up to 4,071,443 shares of common stock,
$0.01 par value per share, of the Company (the "Common Stock"). If any Award
expires or is terminated, surrendered or canceled without having been fully
exercised or is forfeited in whole or in part (including as the result of shares
of Common Stock subject to such Award being repurchased by the Company at the
original issuance price pursuant to a contractual repurchase right) or results
in any Common Stock not being issued, the unused Common Stock covered by such
Award shall again be available for the grant of Awards under the Plan, subject,
however, in the case of Incentive Stock Options (as hereinafter defined), to any
limitations under the Code. Shares issued under the Plan may consist in whole or
in part of authorized but unissued shares or treasury shares.

      5.    STOCK OPTIONS.

            (a)   General. The Board may grant options to purchase Common Stock
(each, an "Option") and determine the number of shares of Common Stock to be
covered by each Option, the exercise price of each Option and the conditions and
limitations applicable to the exercise of each Option, including conditions
relating to applicable federal or state securities laws, as it considers
necessary or advisable. An Option which is not intended to be an Incentive Stock
Option (as hereinafter defined) shall be designated a "Nonstatutory Stock
Option".

            (b)   Incentive Stock Options. An Option that the Board intends to
be an "incentive stock option" as defined in Section 422 of the Code (an
"Incentive Stock Option") shall only be granted to employees of Predix
Pharmaceuticals Holdings, Inc., any of the present or future parent or
subsidiary corporations of Predix Pharmaceuticals Holdings, Inc. as defined in
Sections 424(e) or (f) of the Code, or any other entity the employees of which
are eligible to receive Incentive Stock Options under the Code and shall be
subject to and shall be construed consistently with the requirements of Section
422 of the Code. The Company shall have no liability to a Participant, or any
other party, if an Option (or any part thereof) which is intended to be an
Incentive Stock Option is not an Incentive Stock Option.

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            (c)   Exercise Price. The Board shall establish the exercise price
at the time each Option is granted, which shall be not less than the Fair Market
Value of the Common Stock per share, and specify it in the applicable option
agreement. Fair Market Value of a share of Common Stock means: (i) if the Common
Stock is listed on a national securities exchange or traded in the
over-the-counter market and sales prices are regularly reported for the Common
Stock, the closing or last price of the Common Stock on the composite tape or
other comparable reporting system for the trading day immediately preceding the
applicable date and if such date is not a trading day, the last market trading
day prior to such date; or (ii) if the Common Stock is not traded on a national
securities exchange but is traded on the over-the-counter market, if sales
prices are not regularly reported for the Common Stock for the trading day
referred to in clause (i), and if bid and asked prices for the Common Stock are
regularly reported, the mean between the bid and the asked price for the Common
Stock at the close of trading in the over-the-counter market for the trading day
on which Common Stock was traded immediately preceding the applicable date and
if such date is not a trading day, the last market trading day prior to such
date and (iii) if the Common Stock is neither listed on a national securities
exchange nor traded in the over-the-counter market, such value as the Board, in
good faith, shall determine.

            (d)   Duration of Options. Each Option shall be exercisable at such
times and subject to such terms and conditions as the Board may specify in the
applicable option agreement.

            (e)   Exercise of Option. Options may be exercised by delivery to
the Company of a written notice of exercise signed by the proper person or by
any other form of notice (including electronic notice) approved by the Board
together with payment in full as specified in Section 5(f) for the number of
shares for which the Option is exercised.

            (f)   Payment Upon Exercise. Common Stock purchased upon the
exercise of an Option granted under the Plan shall be paid for as follows:

                  (1)   in cash or by check, payable to the order of the
Company;

                  (2)   except as the Board may, in its sole discretion,
otherwise provide in an option agreement, by (i) delivery of an irrevocable and
unconditional undertaking by a creditworthy broker to deliver promptly to the
Company sufficient funds to pay the exercise price and any required tax
withholding or (ii) delivery by the Participant to the Company of a copy of
irrevocable and unconditional instructions to a creditworthy broker to deliver
promptly to the Company cash or a check sufficient to pay the exercise price and
any required tax withholding;

                  (3)   to the extent permitted by the Board, in its sole
discretion when the Common Stock is registered under the Exchange Act, by
delivery of shares of Common Stock owned by the Participant valued at their Fair
Market Value;

                  (4)   to the extent permitted by the Board, in its sole
discretion by delivery of a promissory note of the Participant to the Company on
terms determined by the Board;

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                  (5)   to the extent permitted by the Board, in its sole
discretion payment of such other lawful consideration as the Board may
determine; or

                  (6)   by any combination of the above permitted forms of
payment.

            (g)   Substitute Options. In connection with a merger or
consolidation of an entity with the Company or the acquisition by the Company of
property or stock of an entity, the Board may grant Options in substitution for
any options or other stock or stock-based awards granted by such entity or an
affiliate thereof. Substitute Options may be granted on such terms as the Board
deems appropriate in the circumstances, notwithstanding any limitations on
Options contained in the other sections of this Section 5 or in Section 2.

      6.    RESTRICTED STOCK.

            (a)   Grants. The Board may grant Awards entitling recipients to
acquire shares of Common Stock, subject to the right of the Company to
repurchase all or part of such shares at their issue price or other stated or
formula price, which shall be not less than the par value of the Common Stock
per share (or to require forfeiture of such shares if issued at no cost) from
the recipient in the event that conditions specified by the Board in the
applicable Award are not satisfied prior to the end of the applicable
restriction period or periods established by the Board for such Award (each, a
"Restricted Stock Award").

            (b)   Terms and Conditions. The Board shall determine the terms and
conditions of any such Restricted Stock Award, including the conditions for
repurchase (or forfeiture) and the issue price, if any.

            (c)   Stock Certificates. Any stock certificates issued in respect
of a Restricted Stock Award shall be registered in the name of the Participant
and, unless otherwise determined by the Board, deposited by the Participant,
together with a stock power endorsed in blank, with the Company (or its
designee). At the expiration of the applicable restriction periods, the Company
(or such designee) shall deliver the certificates no longer subject to such
restrictions to the Participant or if the Participant has died, to the
beneficiary designated, in a manner determined by the Board, by a Participant to
receive amounts due or exercise rights of the Participant in the event of the
Participant's death (the "Designated Beneficiary"). In the absence of an
effective designation by a Participant, Designated Beneficiary shall mean the
Participant's estate.

      7.    OTHER STOCK-BASED AWARDS.

      The Board shall have the right to grant other Awards based upon the Common
Stock having such terms and conditions as the Board may determine, including ,
without limitation, the grant of shares based upon certain conditions, the grant
of securities convertible into Common Stock and the grant of stock appreciation
rights, phantom stock awards or stock units. The principal terms of each
Stock-Based Award shall be set forth in an Agreement, duly executed by the
Company and, to the extent required by law or requested by the Company, by the
Participant. The Agreement shall be in a form approved by the Board and shall
contain terms and conditions which the Board determines to be appropriate and in
the best interest of the Company.

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      8.    ADJUSTMENTS FOR CHANGES IN COMMON STOCK AND CERTAIN OTHER EVENTS.

            (a)   Changes in Capitalization. In the event of any stock split,
reverse stock split, stock dividend, recapitalization, combination of shares,
reclassification of shares, spin-off or other similar change in capitalization
or event, or any distribution to holders of Common Stock other than a normal
cash dividend, (i) the number and class of securities available under this Plan,
(ii) the number and class of securities and exercise price per share subject to
each outstanding Option, (iii) the repurchase price per share subject to each
outstanding Restricted Stock Award, and (iv) the terms of each other outstanding
Award shall be appropriately adjusted by the Company (or substituted Awards may
be made, if applicable) to the extent the Board shall determine, in good faith,
that such an adjustment (or substitution) is necessary and appropriate. If this
Section 8(a) applies and Section 8(c) also applies to any event, Section 8(c)
shall be applicable to such event, and this Section 8(a) shall not be
applicable.

            (b)   Liquidation or Dissolution. In the event of a proposed
liquidation or dissolution of the Company, the Board shall upon written notice
to the Participants provide that all then unexercised Options will (i) become
exercisable in full as of a specified time at least 10 business days prior to
the effective date of such liquidation or dissolution and (ii) terminate
effective upon such liquidation or dissolution, except to the extent exercised
before such effective date. Upon the dissolution or liquidation of the Company,
any outstanding Restricted Stock Award or other Award granted under the Plan
shall immediately terminate unless otherwise determined by the Board at any time
or specifically provided in the applicable Agreement.

            (c)   Reorganization Events.

                  (1)   Definition. A "Reorganization Event" shall mean: (a) any
merger or consolidation of the Company with or into another entity as a result
of which all of the Common Stock of the Company is converted into or exchanged
for the right to receive cash, securities or other property or (b) any exchange
of all of the Common Stock of the Company for cash, securities or other property
pursuant to a share exchange transaction.

                  (2)   Consequences of a Reorganization Event on Options. Upon
the occurrence of a Reorganization Event, or the execution by the Company of any
agreement with respect to a Reorganization Event, the Board shall provide that
all outstanding Options shall be assumed, or equivalent options shall be
substituted, by the acquiring or succeeding corporation (or an affiliate
thereof). For purposes hereof, an Option shall be considered to be assumed if,
following consummation of the Reorganization Event, the Option confers the right
to purchase, for each share of Common Stock subject to the Option immediately
prior to the consummation of the Reorganization Event, the consideration
(whether cash, securities or other property) received as a result of the
Reorganization Event by holders of Common Stock for each share of Common Stock
held immediately prior to the consummation of the Reorganization Event (and if
holders were offered a choice of consideration, the type of consideration chosen
by the holders of a majority of the outstanding shares of Common Stock);
provided, however, that if the consideration received as a result of the
Reorganization Event is not solely common stock of the acquiring or succeeding
corporation (or an affiliate thereof), the Company may, with the consent of the
acquiring or succeeding corporation, provide for the consideration to be
received upon the

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exercise of Options to consist solely of common stock of the acquiring or
succeeding corporation (or an affiliate thereof) equivalent in Fair Market Value
to the per share consideration received by holders of outstanding shares of
Common Stock as a result of the Reorganization Event.

      Notwithstanding the foregoing, if the acquiring or succeeding corporation
(or an affiliate thereof) does not agree to assume, or substitute for, such
Options, then the Board shall, upon written notice to the Participants, provide
that all then unexercised Options (whether or not then exercisable) will become
exercisable in full as of a specified time prior to the Reorganization Event and
will terminate immediately prior to the consummation of such Reorganization
Event, except to the extent exercised by the Participants before the
consummation of such Reorganization Event; provided, however, that in the event
of a Reorganization Event under the terms of which holders of Common Stock will
receive upon consummation thereof a cash payment for each share of Common Stock
surrendered pursuant to such Reorganization Event (the "Acquisition Price"),
then the Board may instead provide that all outstanding Options shall terminate
upon consummation of such Reorganization Event and that each Participant shall
receive, in exchange therefor, a cash payment equal to the amount (if any) by
which (A) the Acquisition Price multiplied by the number of shares of Common
Stock subject to such outstanding Options (whether or not then exercisable),
exceeds (B) the aggregate exercise price of such Options.

      If any Option provides that it may be exercised for shares of Common Stock
which remain subject to a repurchase right in favor of the Company, upon the
occurrence of a Reorganization Event, any shares of restricted stock received
upon exercise of such Option shall be treated in accordance with Section 8(c)(3)
as if they were a Restricted Stock Award.

                  (3)   Consequences of a Reorganization Event on Restricted
Stock Awards. Unless otherwise specified in the applicable Restricted Stock
Award, upon the occurrence of a Reorganization Event, the repurchase and other
rights of the Company under each outstanding Restricted Stock Award shall inure
to the benefit of the Company's successor and shall apply to the cash,
securities or other property which the Common Stock was converted into or
exchanged for pursuant to such Reorganization Event in the same manner and to
the same extent as they applied to the Common Stock subject to such Restricted
Stock Award.

                  (4)   Consequences of a Reorganization Event on Other Awards.
The Board shall specify the effect of a Reorganization Event on any other Award
granted under the Plan at the time of the grant of such Award.

      9.    GENERAL PROVISIONS APPLICABLE TO AWARDS.

            (a)   Transferability of Awards. Except as the Board may otherwise
determine or provide in an Award, Awards shall not be sold, assigned,
transferred, pledged or otherwise encumbered by the person to whom they are
granted, either voluntarily or by operation of law, except by will or the laws
of descent and distribution, and, during the life of the Participant, shall be
exercisable only by the Participant. References to a Participant, to the extent
relevant in the context, shall include references to authorized transferees.

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            (b)   Documentation. Each Award shall be evidenced in such form
(written, electronic or otherwise) as the Board shall determine. Each Award may
contain terms and conditions in addition to those set forth in the Plan.

            (c)   Board Discretion. Except as otherwise provided by the Plan,
each Award may be made alone or in addition or in relation to any other Award.
The terms of each Award need not be identical, and the Board need not treat
Participants uniformly.

            (d)   Termination of Status. The Board shall determine the effect on
an Award of the disability, death, retirement, authorized leave of absence or
other change in the employment or other status of a Participant and the extent
to which, and the period during which, the Participant, the Participant's legal
representative, conservator, guardian or Designated Beneficiary may exercise
rights under the Award.

            (e)   Withholding. Each Participant shall pay to the Company, or
make provision satisfactory to the Board for payment of, any taxes required by
law to be withheld in connection with Awards to such Participant no later than
the date of the event creating the tax liability. Except as the Board may
otherwise provide in an Award, when the Common Stock is registered under the
Exchange Act, Participants may satisfy such tax obligations in whole or in part
by delivery of shares of Common Stock, including shares retained from the Award
creating the tax obligation, valued at their Fair Market Value; provided,
however, that the total tax withholding where stock is being used to satisfy
such tax obligations cannot exceed the Company's minimum statutory withholding
obligations (based on minimum statutory withholding rates for federal and state
tax purposes, including payroll taxes, that are applicable to such supplemental
taxable income). The Company may, to the extent permitted by law, deduct any
such tax obligations from any payment of any kind otherwise due to a
Participant.

            (f)   Amendment of Award. The Board may amend, modify or terminate
any outstanding Award, including but not limited to, buying out for a payment in
cash or shares an Award previously granted, substituting therefor another Award
of the same or a different type covering the same or a different numbers of
shares and having an exercise price or purchase price per share which may be
lower or higher than the exercise price or purchase price of the cancelled
Award, based on such terms and conditions as the Board shall establish and the
Participant shall accept, reducing or increasing the exercise price or purchase
price, changing the date of exercise or realization, and converting an Incentive
Stock Option to a Nonstatutory Stock Option, provided that the Participant's
consent to such action shall be required unless the Board determines that the
action, taking into account any related action, would not materially and
adversely affect the Participant.

            (g)   Conditions on Delivery of Stock. The Company will not be
obligated to deliver any shares of Common Stock pursuant to the Plan or to
remove restrictions from shares previously delivered under the Plan until (i)
all conditions of the Award have been met or removed to the satisfaction of the
Company, (ii) in the opinion of the Company's counsel, all other legal matters
in connection with the issuance and delivery of such shares have been satisfied,
including any applicable securities laws and any applicable stock exchange or
stock market rules and regulations, and (iii) the Participant has executed and
delivered to the Company

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such representations or agreements as the Company may consider appropriate to
satisfy the requirements of any applicable laws, rules or regulations.

            (h)   Acceleration. Notwithstanding anything contained herein to the
contrary, the Board may at any time provide that any Award shall become
immediately exercisable in full or in part, free of some or all restrictions or
conditions, or otherwise realizable in full or in part, as the case may be.

      10.   MISCELLANEOUS.

            (a)   No Right To Employment or Other Status. No person shall have
any claim or right to be granted an Award, and the grant of an Award shall not
be construed as giving a Participant the right to continued employment or any
other relationship with the Company. The Company expressly reserves the right at
any time to dismiss or otherwise terminate its relationship with a Participant
free from any liability or claim under the Plan, except as expressly provided in
the applicable Award.

            (b)   No Rights As Stockholder. Subject to the provisions of the
applicable Award, no Participant or Designated Beneficiary shall have any rights
as a stockholder with respect to any shares of Common Stock to be distributed
with respect to an Award until becoming the record holder of such shares.
Notwithstanding the foregoing, in the event the Company effects a split of the
Common Stock by means of a stock dividend and the exercise price of and the
number of shares subject to such Option are adjusted as of the date of the
distribution of the dividend (rather than as of the record date for such
dividend), then an optionee who exercises an Option between the record date and
the distribution date for such stock dividend shall be entitled to receive, on
the distribution date, the stock dividend with respect to the shares of Common
Stock acquired upon such Option exercise, notwithstanding the fact that such
shares were not outstanding as of the close of business on the record date for
such stock dividend.

            (c)   Effective Date and Term of Plan. The Plan will terminate on
September 21, 2015 the date which is ten (10) years from the earlier of the date
of its adoption by the Board and the date of its approval by the shareholders of
the Company. The Plan may be terminated at an earlier date by vote of the
shareholders or the Board of the Company; provided, however, that any such
earlier termination shall not affect any Agreements executed prior to the
effective date of such termination.

            (d)   Amendment of Plan. The Plan may be amended by the shareholders
of the Company. The Plan may also be amended by the Board, including, without
limitation, to the extent necessary to qualify any or all outstanding Awards
granted under the Plan or Awards to be granted under the Plan for favorable
federal income tax treatment (including deferral of taxation upon exercise) as
may be afforded incentive stock options under Section 422 of the Code, and to
the extent necessary to qualify the shares issuable upon exercise or acceptance
of any outstanding Awards granted, or Awards to be granted, under the Plan for
listing on any national securities exchange or quotation in any national
automated quotation system of securities dealers. Any amendment approved by the
Board which the Board determines is of a scope that requires shareholder
approval shall be subject to obtaining such shareholder approval. Any

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modification or amendment of the Plan shall not, without the consent of a
Participant, adversely affect his or her rights under an Award previously
granted to him or her.

            (e)   Authorization of Sub-Plans. The Board may from time to time
establish one or more sub-plans under the Plan for purposes of satisfying
applicable blue sky, securities or tax laws of various jurisdictions. The Board
shall establish such sub-plans by adopting supplements to this Plan containing
(i) such limitations on the Board's discretion under the Plan as the Board deems
necessary or desirable or (ii) such additional terms and conditions not
otherwise inconsistent with the Plan as the Board shall deem necessary or
desirable. All supplements adopted by the Board shall be deemed to be part of
the Plan, but each supplement shall apply only to Participants within the
affected jurisdiction and the Company shall not be required to provide copies of
any supplement to Participants in any jurisdiction which is not the subject of
such supplement.

            (f)   Governing Law. The provisions of the Plan and all Awards made
hereunder shall be governed by and interpreted in accordance with the laws of
the State of Delaware, without regard to any applicable conflicts of law.

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                      PREDIX PHARMACEUTICALS HOLDINGS INC.

                 AMENDED AND RESTATED 2003 STOCK INCENTIVE PLAN

                                   APPENDIX A

                    SPECIAL PROVISIONS FOR ISRAELI RESIDENTS
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                         APPENDIX A - ISRAELI RESIDENTS

        PREDIX PHARMACEUTICALS HOLDINGS, INC. AMENDED AND RESTATED 2003
                              STOCK INCENTIVE PLAN

1.    SPECIAL PROVISIONS FOR PERSONS WHO ARE ISRAELI RESIDENTS

      1.1   This Appendix (the "APPENDIX") to the Predix Pharmaceuticals
Holdings, Inc. Amended and Restated 2003 Stock Incentive Plan (the "PLAN") is
effective as of August 8, 2003 (the "EFFECTIVE DATE") and amended on September
22, 2005.

      1.2   The provisions specified hereunder apply only to persons who are
residents of the State of Israel or who are deemed to be residents of the State
of Israel for tax purposes.

      1.3   This Appendix applies with respect to (a) Options to purchase Shares
of Common Stock and (b) Shares of Common Stock issued directly, where such
Options or Shares of Common Stock are granted or issued, respectively, under the
Plan. The purpose of this Appendix is to establish certain rules and limitations
applicable to Options which may be granted under the Plan from time to time to
Eligible 102 Participants, consultants or advisors of Predix Pharmaceuticals
Holdings, Inc. and its Affiliates, in compliance with the securities and other
applicable laws currently in force in the State of Israel. Except as otherwise
provided by this Appendix, all grants made pursuant to this Appendix shall be
governed by the terms of the Plan. This Appendix is applicable only to grants
made after the Effective Date. This Appendix complies with, and is subject to
the ITO and Amended Section 102.

      1.4   The Plan and this Appendix shall be read together. In any case of
contradiction, whether explicit or implied, between the provisions of this
Appendix and the Plan, the provisions of this Appendix shall govern.

2.    DEFINITIONS

      Notwithstanding any other provision of the Plan, the following definitions
will apply to grants made pursuant to this Appendix:

      2.1   "3(I) OPTION" means an Option which is subject to taxation pursuant
to Section 3(I) of the ITO which has been granted to any person who is not an
Eligible 102 Participant.

      2.2   "102 CAPITAL GAINS TRACK" means the tax alternative set forth in
Amended Section 102(b)(2) of the ITO pursuant to which income resulting from the
sale of stock derived from Options is taxed as a capital gain.

      2.3   "102 CAPITAL GAINS TRACK GRANT" means a 102 Trustee Grant qualifying
for the special tax treatment under the 102 Capital Gains Track set forth in
Amended Section 102, specifically subsection (b)(2) thereof.

      2.4   "102 ORDINARY INCOME TRACK" means the tax alternative set forth in
Amended Section 102(b)(1) of the ITO pursuant to which income resulting from the
sale of stock derived from Options is taxed as ordinary income.

      2.5   "102 ORDINARY INCOME TRACK GRANT" means a 102 Trustee Grant
qualifying for the ordinary income tax treatment under the 102 Capital Gains
Track set forth in Amended Section 102, specifically subsection (b)(1) thereof.

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      2.6   "102 TRUSTEE GRANT" means an Option, or Shares of Common Stock
granted or issued, as the case may be, pursuant to Section 102(b) of the ITO and
held in trust by a Trustee for the benefit of the Participant, and includes both
102 Capital Gains Track Grants and 102 Ordinary Income Track Grants.

      2.7   "AFFILIATE" means any "employing Company" within the meaning of
Section 102(a) of the ITO.

      2.8   "AMENDED SECTION 102" shall mean the provisions of Section 102 of
the ITO, as amended by the Law Amending the Income Tax Ordinance (Number 132)
2002, effective as of January 1, 2003.

      2.9   "CONTROLLING SHAREHOLDER" shall have the meaning ascribed to it in
Section 32(9) of the ITO.

      2.10  "ELECTION" means the Company's choice of the type (as between
capital gains track or ordinary income track) of 102 Trustee Grants it will make
under the Plan, as filed with the ITA.

      2.11  "ELIGIBLE 102 PARTICIPANT" means a person who is employed by the
Company or its Affiliates, including an individual who is serving as a director
or an office holder, but excluding a Controlling Shareholder.

      2.12  "FAIR MARKET VALUE" shall have the meaning ascribed to it in the
Plan; provided, however, that with respect to 102 Capital Gains Track Grants
only, for the sole purpose of determining tax liability pursuant to Section
102(b)(3) of the ITO, if at the date of grant the Company's shares are listed on
any established stock exchange or a national market system or if the Company's
shares will be registered for trading within ninety (90) days following the date
of grant, then the fair market value of the Shares at the date of grant shall be
determined in accordance with the average closing price of the Company's shares
on the thirty (30) trading days preceding the date of grant or on the first
thirty (30) trading days following the date of registration for trading, as the
case may be.

      2.13  "ITA" means the Israeli Tax Authorities.

      2.14  "ITO" means the Israeli Income Tax Ordinance (New Version) 1961 and
the rules, regulations, orders or procedures promulgated thereunder and any
amendments thereto, including specifically the Rules, all as may be amended from
time to time.

      2.15  "NON-TRUSTEE GRANT" means an Option granted pursuant to Section
102(c)(2) of the ITO or a Share of Common Stock issued pursuant to Section
102(c)(1) of the ITO not held in trust by a Trustee.

      2.16  "OPTIONS" means a Non-Statutory Stock Option granted pursuant to the
Terms and Conditions of the Plan and the Appendix.

      2.17  "REQUIRED HOLDING PERIOD" means the requisite period prescribed by
the ITO and the Rules, or such other period as may be required by the ITA,
during which Options or Common Stock granted by the Company must be held by the
Trustee for the benefit of the person to whom it was granted.

      2.18  "RULES" means the Income Tax Rules (Tax benefits in Stock Issuance
to Employees) 5763-2003.

                                      A-2
<PAGE>
      2.19  "SHARE" means a share of Common Stock, $0.01 par value, of the
Company, subject to adjustments pursuant to Section 8 of the Plan.

      2.20  "TRUSTEE" means a person designated by the Board to serve as a
trustee and approved by the ITA in accordance with the provisions of Section
102(a) of the ITO.

      All capitalized terms contained herein which are not defined in Section 2
above, shall have the meanings attributed to them in the Plan.

3.    TYPES OF GRANTS AND SECTION 102 ELECTION

      3.1   Grants made pursuant to Amended Section 102, whether as grants of
Options or as issuances of Common Stock under the Plan, shall be made pursuant
to either (a) Section 102(b)(2) of the ITO as 102 Capital Gains Track Options;
(b) Section 102(b)(1) of the ITO as 102 Ordinary Income Track Options; or (c)
with regard to Non-Trustee Grants, the grant of an Option shall be made pursuant
to Section 102(c)(2) and the issuance of a Share of Common Stock shall be made
pursuant to Section 102(c)(1). The Company's Election regarding the type of 102
Trustee Grant it chooses to make has to be filed with the ITA. Once the Company
has filed such Election, it may change the type of 102 Trustee Grant that it
chooses to make only after the passage of at least 12 months beginning from the
end of the calendar year in which the first grant was made in accordance with
the previous Election, in accordance with Amended Section 102. For the avoidance
of doubt, such Election shall not prevent the Company from granting Non-Trustee
Grants.

      3.2   Eligible 102 Participants may receive only 102 Trustee Grants or
Non-Trustee Grants. Participants who are not Eligible 102 Participants may be
granted only 3(I) Options under this Appendix.

      3.3   No 102 Trustee Grants may be made effective pursuant to this
Appendix until 30 days after the requisite filings required by the ITO and the
Rules have been made with the ITA.

      3.4   The option agreement or documents evidencing the Options granted or
Shares issued pursuant to the Plan and this Appendix shall indicate whether the
grant is a 102 Trustee Grant, a Non-Trustee Grant or a 3(I) Grant; and, if the
grant is a 102 Trustee Grant, whether it is a 102 Capital Gains Track Grant or a
102 Ordinary Income Track Grant; and if the grant is a Non-Trustee Grant,
whether the grant is subject to the provisions of Section 102(c)(1) or
102(c)(2).

4.    TRUSTEE

      4.1   In accordance with the provisions of the 102 Trustee Grants, any
Shares issued upon exercise of Options granted as 102 Trustee Grants, and other
shares received subsequently following any realization of rights derived from
Shares or Options (including stock dividends), shall be issued to the Trustee
nominated by the Board of Directors and approved in accordance with the
provisions of Section 102 of the ITO and the Rules by the ITA, and shall be held
for the benefit of the Eligible 102 Participant.

            (a)   In accordance with the provisions of the 102 Trustee Grants,
Options (including any Shares received following exercise of Options) or Shares
of Common Stock, shall be held by the Trustee for at least the duration of the
Required Holding Period. At the end of the Required Holding Period, the Trustee
may release the Options or the Shares to the Participant,

                                      A-3
<PAGE>
only after (i) the receipt by the Trustee of an acknowledgment that the
Participant has paid all applicable tax due pursuant to the ITO and the Rules,
or (ii) the Trustee withholds any applicable tax due pursuant to the ITO and the
Rules. The Trustee shall not release any Options or Shares issued upon exercise
of Options prior to the full payment of the Participant's tax liabilities.
During the Restricted Holding Period, the Participant shall not require the
Trustee to release or sell the Options or Shares and other shares received
subsequently following any realization of rights derived from Shares or Options
(including stock dividends) to the Participant or to a third party, unless
permitted to do so by applicable law. Notwithstanding the above, such sale or
release during the Restricted Holding Period will result in different tax
ramifications under Section 102 of the ITO and the Rules and/or any other
regulations or orders or procedures promulgated thereunder, which shall apply to
and shall be borne by such Eligible 102 Participant.

            (b)   The Trustee and each Participant shall comply with the ITO,
the Rules, and the terms and conditions of the Trust Agreement entered into
between the Company and the Trustee.

            (c)   In the event a stock dividend is declared on Shares which
derive from Options granted as 102 Trustee Grants, such dividend shall also be
subject to the provisions of this Section and the Required Holding Period for
such dividend shares shall be measured from the commencement of the Required
Holding Period for the Option or Shares with respect to which the dividend was
declared.

            (d)   Upon receipt of the 102 Trustee Grant, the Eligible 102
Participant will sign an undertaking to release the Trustee from any liability
in respect of any action or decision duly taken and bona fide executed in
relation with the Plan, or any Option or Share granted to the Eligible 102
Participant thereunder. In addition, the Eligible 102 Participant shall execute
any and all documents, which the Company or the Trustee may reasonably determine
to be necessary in order to comply with the ITO and the Rules.

            (e)   If an Option granted as a 102 Trustee Grant is exercised
during the Required Holding Period, the Shares issued upon such exercise shall
be issued in the name of the Trustee for the benefit of the Eligible 102
Participant. If such an Option is exercised after the Required Holding Period
ends, the Shares issued upon such exercise shall, at the election of the
Eligible 102 Participant, either (i) be issued in the name of the Trustee, or
(ii) be transferred to the Eligible 102 Participant directly, provided that the
Eligible 102 Participant first complies with the provisions of Section 4.1(a)
above and Section 6 of the Plan.

            (f)   The Trustee shall have no rights to equity participation as to
the Shares held in trust.

      4.2   Options granted under the Plan pursuant to the provisions of Section
3(I) of the ITO may be granted to a Trustee if the Company so desires.

5.    Assignability

      As long as Options or Shares are held by the Trustee on behalf of the
Eligible 102 Participant, all rights of the Eligible 102 Participant over the
shares are personal, can not be transferred, assigned, pledged or mortgaged,
other than by will or laws of descent and distribution.

                                      A-4
<PAGE>
6.    Integration of Section 102 of the ITO

      With regards to all 102 Grants, the provisions of the Plan and/or the
Appendix and/or the option agreement shall be subject to the provisions of
Section 102 of the ITO. In the event that the Tax Assessing Officer imposes
terms and conditions not specified herein, such terms and conditions will apply
to 102 Grants granted hereunder.

7.    Tax Consequences

      7.1   Any tax consequences arising from the grant or exercise of any
Option, from the payment for Shares covered thereby, the grant of Shares, or
from any other event or act (of the Company, and/or its Affiliates, and the
Trustee or the Participant), hereunder, shall be borne solely by the
Participant. The Company and/or its Affiliates, and/or the Trustee shall
withhold taxes according to the requirements under the applicable laws, rules,
and regulations, including withholding taxes at source. Furthermore, the
Participant shall agree to indemnify the Company and/or its Affiliates and/or
the Trustee and hold them harmless against and from any and all liability for
any such tax or interest or penalty thereon, including without limitation,
liabilities relating to the necessity to withhold, or to have withheld, any such
tax from any payment made to the Participant. The Company or any of its
Affiliates and the Trustee may make such provisions and take such steps as it
may deem necessary or appropriate for the withholding of all taxes required by
law to be withheld with respect to Options granted under the Plan and the
exercise thereof, including, but not limited, to (i) deducting the amount so
required to be withheld from any other amount then or thereafter payable to a
Participant, and/or (ii) requiring a Participant to pay to the Company or any of
its Affiliates the amount so required to be withheld as a condition of the
issuance, delivery, distribution or release of any Shares. In addition, the
Participant will be required to pay any amount which exceeds the tax to be
withheld and transferred to the tax authorities, pursuant to applicable Israeli
tax regulations.

      7.2   With respect to the grant of Options under the provisions of the
Non-Trustee Grants specified in Section 102(c)(2), if the Participant ceases to
be employed by the Company or any Affiliate, the Participant shall extend to the
Company and/or its Affiliate a security or guarantee for the payment of tax due
at the time of sale of Shares, all in accordance with the provisions of Section
102 of the ITO and the Rules.

8.    Governing Law and Jurisdiction

Notwithstanding any other provision of the Plan, with respect to Participants
subject to this Appendix, the Plan and all instruments issued thereunder or in
connection therewith shall be governed by, and interpreted in accordance with,
the laws of the State of Israel applicable to contracts made and to be performed
therein. In case of a dispute relating to any matters pertaining to this
Appendix, the parties shall submit the dispute to be settled by arbitration by a
mutually agreed single arbitrator, or in the absence of agreement, by an
arbitrator chosen by the Chairman of the Israel Bar Association, in accordance
with the Israeli Arbitration Law. The arbitrator selected shall apply
substantive Israeli law, but shall not be bound by laws of procedure and
evidence. The arbitrator shall set forth the grounds for his or her decision in
a written judgment. The decision of the arbitrator shall be final and binding on
all parties involved, and judgment upon his or her decision may be entered in a
court of competent jurisdiction.

                                      A-5<PAGE>
                                                                  Exhibit 10.1.1

                      PREDIX PHARMACEUTICALS HOLDINGS, INC.

                 AMENDED AND RESTATED 2003 STOCK INCENTIVE PLAN

                                SENIOR EXECUTIVE
                        INCENTIVE STOCK OPTION AGREEMENT

                                      WITH

                               [NAME OF EMPLOYEE]
                                 (EMPLOYEE COPY)

                         (sign and keep this document for your future reference)
<PAGE>
                      PREDIX PHARMACEUTICALS HOLDINGS, INC.

                 AMENDED AND RESTATED 2003 STOCK INCENTIVE PLAN

                                SENIOR EXECUTIVE
                        INCENTIVE STOCK OPTION AGREEMENT

                                      WITH

                               [NAME OF EMPLOYEE]

                                 (COMPANY COPY)

                                      (sign and return this copy to the Company)
<PAGE>
                      PREDIX PHARMACEUTICALS HOLDINGS, INC.

                                SENIOR EXECUTIVE
                        INCENTIVE STOCK OPTION AGREEMENT
          GRANTED UNDER AMENDED AND RESTATED 2003 STOCK INCENTIVE PLAN

     1.   GRANT OF OPTION.

     This agreement evidences the grant by Predix Pharmaceuticals Holdings,
Inc., a Delaware corporation (the "Company"), on [INSERT DATE], 200__, (the
"Grant Date") to [INSERT NAME OF GRANTEE], an employee of the Company (the
"Participant"), of an option (the "Option") to purchase, in whole or in part, on
the terms provided herein and in the Company's Amended and Restated 2003 Stock
Incentive Plan (the "Plan"), a total of [INSERT # OF SHARES] shares (the
"Shares") of common stock, $0.01 par value per share, of the Company (the
"Common Stock") at a price of $_____ per Share (the "Exercise Price"), which
Exercise Price must be at least 100% of the fair market value of the Common
Stock on the date of grant (or 110% in the case of a Participant that owns more
than 10% of the total combined voting power of all classes of stock of the
Company or its parent or subsidiary (a "10% Shareholder")). Unless earlier
terminated, this Option shall expire at 5:00 p.m., Eastern time, on [INSERT DATE
10 YEARS FROM DATE OF GRANT, UNLESS 10% OWNER INSERT DATE 5 YEARS FROM DATE OF
GRANT], 20__ (the "Final Exercise Date"), which date must be no more than 10
years (5 years in the case of a 10% Shareholder) from the Grant Date.

     It is intended that the Option evidenced by this agreement shall be an
incentive stock option as defined in Section 422 of the Internal Revenue Code of
1986, as amended, and any regulations promulgated thereunder (the "Code").
Except as otherwise indicated by the context, the term "Participant", as used in
this option agreement, shall be deemed to include any person who acquires the
right to exercise this Option validly under its terms.

     2.   VESTING SCHEDULE.

     Subject to the terms and conditions of this Agreement, this Option to
purchase the Shares shall become exercisable ("vest") in 48 monthly
installments. Each installment shall consist of 2.0833% of the total number of
the Shares. Such installments shall become exercisable on the first day of each
month beginning on [INSERT DATE]. The number of shares included in each of the
first 47 installments shall be rounded down to the nearest whole number, whilst
the number of shares included in the 48th and final installment shall be the
remaining unvested balance of the Shares. [INSERT FOR NEW EMPLOYEES OR
CONSULTANTS THE FOLLOWING: NOTWITHSTANDING THE FOREGOING, THIS OPTION SHALL NOT
BE EXERCISABLE FOR ANY SHARES UNTIL THE DATE THAT THE PARTICIPANT HAS PROVIDED
SERVICES TO THE COMPANY OF ANY AFFILIATE THEREOF FOR A PERIOD OF ONE YEAR.]

     The right of exercise shall be cumulative so that to the extent the Option
is not exercised in any period to the maximum extent permissible it shall
continue to be exercisable, in whole or in part, with respect to all Shares for
which it is vested until the earlier of the Final Exercise Date or the
termination of this Option under Section 3 hereof or the Plan.

                                      -3-
<PAGE>
     Notwithstanding anything to the contrary herein and in addition to, and not
in contradiction with, the existing acceleration provisions provided under
Section 8(c) of the Plan, the Shares shall become immediately exercisable in
full if, after a Reorganization Event (as defined in the Plan), the acquiring or
succeeding entity assumes this Option or substitutes equivalent securities for
this Option, and (i) the Participant is terminated by the acquiring or
succeeding entity without "cause" (as defined in Section 3(e) below) within 12
months of the consummation of such Reorganization Event, or (ii) the Participant
terminates his or her employment with the acquiring or succeeding entity within
12 months of the consummation of such Reorganization Event due to a material
adverse change in the Participant's duties, authority or responsibilities (as of
the date of the consummation of the Reorganization Event) which causes the
Participant's position with the acquiring or succeeding entity to become of less
responsibility or authority; provided that, such Shares shall not become fully
exercisable after the Final Exercise Date or the termination of this Option
under Section 3 hereof or the Plan.

     3.   EXERCISE OF OPTION.

          (a) Form of Exercise. Each election to exercise this Option shall be
(i) by written notice in the form attached hereto as Exhibit A, duly signed by
the Participant and received by the Company or its designee, and (ii) payment in
full of the Exercise Price for each Share purchased upon exercise of this
Option. Payment of the Exercise Price for each Share shall be made in accordance
with Section 5(f) of the Plan. The Participant may purchase less than the number
of shares covered hereby, provided that no partial exercise of this Option may
be for any fractional share. The Company shall deliver such Shares as soon as
practicable after the notice shall be received, provided, however, that the
Company may delay issuance of such Shares until all conditions set forth in
Section 9(g) of the Plan have been satisfied. The Shares as to which the Option
shall have been so exercised shall be registered in the Company's share register
in the name of the person so exercising the Option (or, if the Option shall be
exercised by the Participant and if the Participant shall so request in the
notice exercising the Option, shall be registered in the name of the Participant
and another person jointly, with right of survivorship) and shall be delivered
as provided above to or upon the written order of the person exercising the
Option. In the event the Option shall be exercised, pursuant to Section 3(d)
hereof, by any person other than the Participant, such notice shall be
accompanied by appropriate proof of the right of such person to exercise the
Option.

          (b) Continuous Relationship with the Company Required. Except as
otherwise provided in this Section 3, this Option may not be exercised unless
the Participant, at the time he or she exercises this Option, is, and has been
at all times since the Grant Date, an employee or officer of, or consultant or
advisor to, the Company or any other entity whose employees are eligible to
receive options under the Plan (an "Eligible Participant").

          (c) Termination of Relationship with the Company. If the Participant
ceases to be an Eligible Participant for any reason, then, except as provided in
paragraphs (d) and (e) below, the right to exercise this Option shall terminate
three months after such cessation (but in no event after the Final Exercise
Date), provided that this Option shall be exercisable only to the extent that
the Participant was entitled to exercise this Option on the date of such
cessation. Notwithstanding the foregoing, if the Participant, prior to the Final
Exercise Date, violates the non-competition or confidentiality provisions of any
employment contract, confidentiality and

                                      -4-
<PAGE>
nondisclosure agreement or other agreement between the Participant and the
Company, the right to exercise this Option shall terminate immediately upon
written notice to the Participant from the Company describing such violation.

          (d) Exercise Period Upon Death or Disability. If the Participant dies
or becomes disabled (within the meaning of Section 22(e)(3) of the Code) prior
to the Final Exercise Date while he or she is an Eligible Participant and the
Company has not terminated such relationship for "Cause" as specified in
paragraph (e) below, this Option shall be exercisable, within the period of one
year following the date of death or disability of the Participant, by the
Participant (or in the case of death by an authorized transferee), provided that
this Option shall be exercisable only to the extent that this Option was
exercisable by the Participant on the date of his or her death or disability,
and further provided that this Option shall not be exercisable after the Final
Exercise Date.

          (e) Discharge for Cause. If the Participant, prior to the Final
Exercise Date, is discharged by the Company for "Cause" (as defined below), the
right to exercise this Option shall terminate immediately upon notice of such
discharge. "Cause" shall mean willful misconduct by the Participant or willful
failure by the Participant to perform his or her responsibilities to the Company
(including, without limitation, breach by the Participant of any provision of
any employment, consulting, advisory, nondisclosure, non-competition or other
similar agreement between the Participant and the Company), as determined by the
Company, which determination shall be conclusive. The Participant shall be
considered to have been discharged for "Cause" if the Company determines, within
30 days after the Participant's resignation, that discharge for Cause was
warranted.

     4.   AGREEMENT IN CONNECTION WITH PUBLIC OFFERINGS.

     If, in connection with a registration statement filed by the Company
pursuant to the Securities Act of 1933, as amended, the Company or its
underwriter so requests, the Participant will agree not to sell any Shares for a
period not to exceed 180 days following the effectiveness of such registration.

     5.   TAX MATTERS.

          (a) Withholding. No Shares will be issued pursuant to the exercise of
this Option unless and until the Participant pays to the Company, or makes
provision satisfactory to the Company for payment of, any federal, state or
local withholding taxes required by law to be withheld in respect of this Option
in accordance with Section 9(e) of the Plan.

          (b) Disqualifying Disposition. If the Participant disposes of Shares
acquired upon exercise of this Option within two years from the Grant Date or
one year after such Shares were acquired pursuant to exercise of this Option,
the Participant shall notify the Company in writing of such disposition.

     6.   NONTRANSFERABILITY OF OPTION.

     This Option may not be sold, assigned, transferred, pledged or otherwise
encumbered by the Participant, either voluntarily or by operation of law, except
by will or the laws of descent

                                      -5-
<PAGE>
and distribution, and, during the lifetime of the Participant, this Option shall
be exercisable only by the Participant.

     7.   PROVISIONS OF THE PLAN.

     This Option is subject to the provisions of the Plan, a copy of which is
furnished to the Participant with this Option.

     8.   NO OBLIGATION TO MAINTAIN RELATIONSHIP.

     The Company is not by the Plan or this Option obligated to continue the
Participant as an employee, director or consultant of the Company. The
Participant acknowledges: (i) that the Plan is discretionary in nature and may
be suspended or terminated by the Company at any time; (ii) that the grant of
the Option is a one-time benefit which does not create any contractual or other
right to receive future grants of options, or benefits in lieu of options; (iii)
that all determinations with respect to any such future grants, including, but
not limited to, the times when options shall be granted, the number of shares
subject to each option, the option price, and the time or times when each option
shall be exercisable, will be at the sole discretion of the Company; (iv) that
the Participant's participation in the Plan is voluntary; (v) that the value of
the Option is an extraordinary item of compensation which is outside the scope
of the Participant's employment contract, if any; and (vi) that the Option is
not part of normal or expected compensation for purposes of calculating any
severance, resignation, redundancy, end of service payments, bonuses,
long-service awards, pension or retirement benefits or similar payments.

     9.   GOVERNING LAW.

     This Agreement shall be construed and enforced in accordance with the law
of the State of Delaware, without giving effect to the conflict of law
principles thereof. For the purpose of litigating any dispute that arises under
this Agreement, the parties hereby consent to exclusive jurisdiction in
Massachusetts and agree that such litigation shall be conducted in the courts of
Middlesex County, Massachusetts or the federal courts of the United States for
the District of Massachusetts.

     10.  BENEFIT OF AGREEMENT.

     Subject to the provisions of the Plan and the other provisions hereof, this
Agreement shall be for the benefit of and shall be binding upon the heirs,
executors, administrators, successors and assigns of the parties hereto.

     11.  ENTIRE AGREEMENT.

     This Agreement, together with the Plan, embodies the entire agreement and
understanding between the parties hereto with respect to the subject matter
hereof and supersedes all prior oral or written agreements and understandings
relating to the subject matter hereof. No statement, representation, warranty,
covenant or agreement not expressly set forth in this Agreement shall affect or
be used to interpret, change or restrict the express terms and provisions

                                      -6-
<PAGE>
of this Agreement, provided, however, in any event, this Agreement shall be
subject to and governed by the Plan.

     12.  MODIFICATIONS AND AMENDMENTS.

     The terms and provisions of this Agreement may be modified or amended as
provided in the Plan.

     13.  DATA PRIVACY.

     By entering into this Agreement, the Participant: (i) authorizes the
Company and each affiliate, and any agent of the Company or any affiliate
administering the Plan or providing Plan record keeping services, to disclose to
the Company or any of its affiliates such information and data as the Company or
any such affiliate shall request in order to facilitate the grant of options and
the administration of the Plan; (ii) waives any data privacy rights he or she
may have with respect to such information; and (iii) authorizes the Company and
each affiliate to store and transmit such information in electronic form.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -7-
<PAGE>
     IN WITNESS WHEREOF, the Company has caused this Option to be executed under
its corporate seal by its duly authorized officer. This Option shall take effect
as a sealed instrument.

                                        PREDIX PHARMACEUTICALS HOLDINGS, INC.

Dated: [DATE OF GRANT]                  By:
                                            ------------------------------------
                                        Name: CHEN SCHOR
                                        Title: CHIEF BUSINESS OFFICER

                                      -8-
<PAGE>
                            PARTICIPANT'S ACCEPTANCE

     The undersigned hereby accepts the foregoing Option and agrees to the terms
and conditions thereof. The undersigned hereby acknowledges receipt of a copy of
the Company's Amended and Restated 2003 Stock Incentive Plan.

                                        PARTICIPANT:

                                        Signature:
                                                   -----------------------------
                                        Name: [NAME OF PARTICIPANT]

                                        Address:
                                                 -------------------------------

                                                 -------------------------------

                                                 -------------------------------
<PAGE>
                                    EXHIBIT A

                    NOTICE OF INCENTIVE STOCK OPTION EXERCISE

Date: _____________

Participant name and address:

[NAME OF PARTICIPANT]

_____________________________________

_____________________________________

Attention: Treasurer

Dear Sir or Madam:

     I am the holder of an Incentive Stock Option granted to me under the Predix
Pharmaceuticals Holdings, Inc. (the "Company") Amended and Restated 2003 Stock
Incentive Plan on [INSERT DATE OF GRANT] for the purchase of [INSERT NUMBER OF
SHARES] shares of Common Stock of the Company at a purchase price of $____ per
share.

     I understand the nature of the investment I am making and the financial
risks thereof. I am aware that it is my responsibility to have consulted with
competent tax and legal advisors about the relevant national, state and local
income tax and securities laws affecting the exercise of the Option and the
purchase and subsequent sale of the Shares.

     I hereby exercise my Option to purchase _________ shares of Common Stock
(the "Shares"), at an exercise price of $________.

     I am paying the option exercise price for the Shares as follows:

     ______________________________________________________________________

     Please issue the Shares (check one):

     [ ]  to me; or

     [ ]  to me and ___________________________, as joint tenants with right of
          survivorship,

     Tax I.D. #: _________________________
<PAGE>
     at the following address:

     _____________________________________

     _____________________________________

     _____________________________________

My mailing address for shareholder communications, if different from the address
listed above, is:

     _____________________________________

     _____________________________________

     _____________________________________

Very truly yours,

-------------------------------------
(Signature)

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