Document:

EX-4.1

 Exhibit 4.1 
  

 
  

CAPITAL ONE MULTI-ASSET EXECUTION TRUST 

as Issuer 
 and 

THE BANK OF NEW YORK MELLON 

as Indenture Trustee 
 CLASS A(2014-1) TERMS DOCUMENT 
 dated as of February 10, 2014 

TO 
 CARD SERIES INDENTURE
SUPPLEMENT 
 dated as of October 9, 2002, 

as amended by the First Amendment thereto dated as of March 1, 2008 

TO 
 ASSET POOL 1 SUPPLEMENT

 dated as of October 9, 2002, 

as amended by the First Amendment thereto dated as of March 1, 2008 

to 
 INDENTURE 

dated as of October 9, 2002, as amended and restated as of January 13, 2006, 

and as further amended by the First Amendment thereto dated as of March 1, 2008 

 
  

 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	 ARTICLE I
	 	Definitions and Other Provisions of General Application	  	 	1	  
		
	 Section 1.01. Definitions
	  	 	1	  
	 Section 1.02. Governing Law
	  	 	8	  
	 Section 1.03. Counterparts
	  	 	8	  
	 Section 1.04. Ratification of Indenture, Asset Pool 1 Supplement and Indenture Supplement
	  	 	8	  
			
	 ARTICLE II
	 	The Class A(2014-1) Notes	  	 	9	  
		
	 Section 2.01. Creation and Designation
	  	 	9	  
	 Section 2.02. Adjustments to Required Subordinated Percentages
	  	 	9	  
	 Section 2.03. Interest Payment
	  	 	10	  
	 Section 2.04. Calculation Agent; Determination of LIBOR
	  	 	10	  
	 Section 2.05. Payments of Interest and Principal
	  	 	11	  
	 Section 2.06. Form of Delivery of Class A(2014-1) Notes; Depository;
Denominations
	  	 	12	  
	 Section 2.07. Delivery and Payment for the Class A(2014-1) Notes
	  	 	12	  
	 Section 2.08. Targeted Deposits to the Accumulation Reserve Account
	  	 	12	  

  
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 THIS CLASS A(2014-1) TERMS DOCUMENT (this “Terms
Document”), by and between CAPITAL ONE MULTI-ASSET EXECUTION TRUST, a statutory trust created under the laws of the State of Delaware (the “Issuer”), having its principal office at
E. A. Delle Donne Corporate Center, Montgomery Building, 1011 Centre Road, Wilmington, DE 19805 and THE BANK OF NEW YORK MELLON, a New York banking corporation, as Indenture Trustee (the “Indenture Trustee”), is made and
entered into as of February 10, 2014. 
 Pursuant to this Terms Document, the Issuer shall create a new tranche of Class A Notes
and shall specify the principal terms thereof. 
 ARTICLE I 

Definitions and Other Provisions of General Application 

Section 1.01. Definitions. For all purposes of this Terms Document, except as otherwise expressly provided or unless the
context otherwise requires: 
  

	 	(1)	the terms defined in this Article have the meanings assigned to them in this Article, and include the plural as well as the singular; 

 

	 	(2)	all other terms used herein which are defined in the Indenture Supplement, the Asset Pool 1 Supplement or the Indenture, either directly or by reference therein, have the meanings assigned to them therein;

  

	 	(3)	all accounting terms not otherwise defined herein have the meanings assigned to them in accordance with generally accepted accounting principles and, except as otherwise herein expressly provided, the term
“generally accepted accounting principles” with respect to any computation required or permitted hereunder means such accounting principles as are generally accepted in the United States of America at the date of such computation;

  

	 	(4)	all references in this Terms Document to designated “Articles,” “Sections” and other subdivisions are to the designated Articles, Sections and other subdivisions of this Terms Document;

  

	 	(5)	the words “herein,” “hereof” and “hereunder” and other words of similar import refer to this Terms Document as a whole and not to any particular Article, Section or other subdivision;

  

	 	(6)	in the event that any term or provision contained herein shall conflict with or be inconsistent with any term or provision contained in the Indenture Supplement, the Asset Pool 1 Supplement, the Indenture or the
Transfer and Administration Agreement, the terms and provisions of this Terms Document shall be controlling; 

  
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	 	(7)	each capitalized term defined herein shall relate only to the Class A(2014-1) Notes and no other Tranche of Notes issued by the Issuer; and 

 

	 	(8)	“including” and words of similar import will be deemed to be followed by “without limitation.” 

“Accumulation Period Amount” means $79,166,666.67; provided, however, if the Accumulation Period Length is
determined to be less than twelve (12) months pursuant to Section 3.10(b)(ii) of the Indenture Supplement, the Accumulation Period Amount shall be the amount specified in the definition of “Accumulation Period Amount” in
the Indenture Supplement. 
 “Accumulation Reserve Funding Period” shall mean, (a) if the Accumulation Period Length
is determined to be one (1) month, there shall be no Accumulation Reserve Funding Period and (b) otherwise, the period (x) commencing on the earliest to occur of (i) the Monthly Period beginning three (3) calendar months
prior to the first Distribution Date for which a budgeted deposit is targeted to be made into the Principal Funding sub-Account of the Class A(2014-1) Notes
pursuant to Section 3.10(b) of the Indenture Supplement, (ii) the Monthly Period following the first Distribution Date following and including the December 2014 Distribution Date for which the Quarterly Excess Spread Percentage
is less than 2%, but in such event the Accumulation Reserve Funding Period shall not be required to commence earlier than 12 months prior to the first Distribution Date for which a budgeted deposit is targeted to be made into the Principal Funding
sub-Account for the Class A(2014-1) Notes pursuant to Section 3.10(b) of the Indenture Supplement, (iii) the Monthly Period following the first Distribution Date following and including the
June 2015 Distribution Date for which the Quarterly Excess Spread Percentage is less than 3%, but in such event the Accumulation Reserve Funding Period shall not be required to commence earlier than 6 months prior to the first Distribution Date
for which a budgeted deposit is targeted to be made into the Principal Funding sub-Account for the Class A(2014-1) Notes pursuant to Section 3.10(b) of the
Indenture Supplement, and (iv) the Monthly Period following the first Distribution Date following and including the August 2015 Distribution Date for which the Quarterly Excess Spread Percentage is less than 4%, but in such event the
Accumulation Reserve Funding Period shall not be required to commence earlier than 4 months prior to the first Distribution Date for which a budgeted deposit is targeted to be made into the Principal Funding
sub-Account for the Class A(2014-1) Notes pursuant to Section 3.10(b) of the Indenture Supplement and (y) ending on the close of business on the last
day of the Monthly Period preceding the earlier to occur of (i) the Expected Principal Payment Date for the Class A(2014-1) Notes and (ii) the date on which the Class
A(2014-1) Notes are paid in full. 
 “Asset Pool 1 Supplement” means the Asset Pool
1 Supplement dated as of October 9, 2002, as amended by the First Amendment thereto, dated as of March 1, 2008, by and between the Issuer and the Indenture Trustee, as amended and supplemented from time to time. 

  
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 “Base Rate” means, with respect to any Monthly Period, the sum of (a) the
Card Series Servicing Fee Percentage and (b) the weighted average (based on the Outstanding Dollar Principal Amount of the related Card Series Notes) of the following: 

(i) in the case of a Tranche of Card Series Dollar Interest-bearing Notes with no
Derivative Agreement for interest, the rate of interest applicable to such Tranche for the period from and including the Monthly Interest Accrual Date for such Tranche of Card Series Dollar Interest-bearing
Notes in such Monthly Period to but excluding the Monthly Interest Accrual Date for such Tranche of Card Series Dollar Interest-bearing Notes in the following Monthly Period; 

(ii) in the case of a Tranche of Card Series Discount Notes, the rate of accretion (converted to an accrual rate) of such
Tranche for the period from and including the Monthly Interest Accrual Date for such Tranche of Card Series Discount Notes in such Monthly Period to but excluding the Monthly Interest Accrual Date for such Tranche of Card Series Discount Notes in
the following Monthly Period; 
 (iii) in the case of a Tranche of Card Series Notes with a Performing Derivative Agreement
for interest, the rate at which payments by the Issuer to the applicable Derivative Counterparty accrue (prior to the netting of such payments, if applicable) for the period from and including the Monthly Interest Accrual Date for such Tranche of
Card Series Notes in such Monthly Period to but excluding the Monthly Interest Accrual Date for such Tranche of Card Series Notes in the following Monthly Period; provided, however, that in the case of a Tranche of Card Series Notes with a
Performing Derivative Agreement for interest in which the rating on such Tranche of Card Series Notes is not dependant upon the rating of the applicable Derivative Counterparty, the amount determined pursuant to this clause (iii) will be the
higher of (1) the rate determined pursuant to this clause (iii) above and (2) the rate of interest applicable to such Tranche for the period from and including the Monthly Interest Accrual Date for such Tranche of Card Series Notes in
such Monthly Period to but excluding the Monthly Interest Accrual Date for such Tranche of Card Series Notes in the following Monthly Period; and 

(iv) in the case of a tranche of Card Series Notes with a non-Performing Derivative
Agreement for interest, the rate specified for that date in the related Terms Document. 
 “Calculation Agent” is defined
in Section 2.04(a). 
 “Class A(2014-1) Adverse Event” means the
occurrence of any of the following: (a) an Early Redemption Event with respect to the Class A(2014-1) Notes or (b) an Event of Default and acceleration of the Class
A(2014-1) Notes. 
 “Class A(2014-1) Note”
means any Note, substantially in the form set forth in Exhibit A-2 to the Indenture Supplement, designated therein as a Class A(2014-1) Note and duly executed and
authenticated in accordance with the Indenture. 

  
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 “Class A(2014-1) Noteholder” means a
Person in whose name a Class A(2014-1) Note is registered in the Note Register. 
 “Class A(2014-1) Termination Date” means the earliest to occur of (a) the Principal Payment Date on which the Outstanding Dollar Principal Amount of the Class A(2014-1)
Notes is paid in full, (b) the Legal Maturity Date and (c) the date on which the Indenture is discharged and satisfied pursuant to Article VI thereof. 

“Excess Spread Percentage” shall mean, with respect to any Distribution Date, the amount, if any, by which the Portfolio
Yield for the preceding Monthly Period exceeds the Base Rate for such Monthly Period. 
 “Expected Principal Payment Date”
means January 17, 2017. 
 “Initial Dollar Principal Amount” means $950,000,000. 

“Indenture” means the Indenture dated as of October 9, 2002, as amended and restated as of January 13, 2006, and as
further amended by the First Amendment thereto, dated as of March 1, 2008, by and between the Issuer and the Indenture Trustee, as amended and supplemented from time to time. 

“Indenture Supplement” means the Card Series Indenture Supplement dated as of October 9, 2002, as amended by the First
Amendment thereto, dated as of March 1, 2008, by and between the Issuer and the Indenture Trustee, as amended and supplemented from time to time. 

“Interest Payment Date” means the fifteenth day of each January, April, July and October, commencing in April 2014, or if
such fifteenth day is not a Business Day, the next succeeding Business Day; provided, however, that if any Early Redemption Event with respect to the Class A(2014-1) Notes or an Event of Default
of the Class A(2014-1) Notes shall have occurred, each succeeding Distribution Date (as such term is defined in the Pooling and Servicing Agreement) shall be an Interest Payment Date. 

“Interest Period” means, with respect to any Interest Payment Date, the period from and including the previous Interest
Payment Date through the day preceding such Interest Payment Date; provided, however, the first Interest Period shall be the period from and including the Issuance Date to but excluding the first Interest Payment Date for the Class
A(2014-1) Notes, April 15, 2014. 
 “Issuance Date” means February 10, 2014. 

“Legal Maturity Date” means November 15, 2019. 

“LIBOR” means, for any Interest Period, the London interbank offered rate for one-month United States dollar deposits
determined by the Calculation Agent on the LIBOR Determination Date for such Interest Period in accordance with the provisions of Section 2.04; provided, however, that if an Early Redemption Event with respect to the Class A(2014-1) Notes 

  
 4 

 or an Event of Default for the Class A(2014-1) Notes occurs, LIBOR means,
as of any LIBOR Determination Date occurring on or after such Early Redemption Event or Event of Default, the London interbank offered rate for one-month United States dollar deposits. 

“LIBOR Determination Date” means February 6, 2014 for the period from and including the Issuance Date to but excluding
April 15, 2014, and the second London Business Day prior to the commencement of the second and each subsequent Interest Period. 

“London Business Day” means any Business Day on which dealings in deposits in United States Dollars are transacted in the
London interbank market. 
 “Maximum Subordination Amount of Class B Notes” means, for the Class A(2014-1) Notes for any date of determination, an amount equal to the product of (a) Adjusted Outstanding Dollar Principal Amount of the Class A(2014-1) Notes on such
date of determination and (b) the percentage equivalent of a fraction, the numerator of which is 9 and the denominator of which is 83.00. 

“Note Interest Rate” means a rate per annum equal to 0.20% in excess of LIBOR as determined by the Calculation Agent on the
related LIBOR Determination Date with respect to each Interest Period. 
 “Paying Agent” means The Bank of New York Mellon.

 “Portfolio Yield” means, with respect to any Monthly Period, the annualized percentage equivalent of a fraction: 

(a) the numerator of which is equal to the sum of: 

(i) the aggregate amount of Finance Charge Amounts allocated to the Card Series with respect to such Monthly Period;
plus 
 (ii) the aggregate amount of Interest Funding sub-Account Earnings on
all Tranches of Card Series Notes for such Monthly Period; plus 
 (iii) any amounts to be treated as Card Series
Finance Charge Amounts pursuant to Sections 3.20(d) and 3.27(a) of the Indenture Supplement; minus 

(iv) the excess, if any, of (1) the sum of the PFA Prefunding Earnings Shortfall plus the PFA Accumulation Earnings
Shortfall over (2) the sum of the aggregate amount to be treated as Card Series Finance Charge Amounts for such Monthly Period pursuant to Sections 3.04(a)(ii) and 3.25(a) of the Indenture Supplement plus any other amounts
applied to cover earnings shortfalls on amounts in the Principal Funding sub-Account for any tranche of Card Series Notes for such Monthly Period; minus 

(v) the Card Series Default Amount for such Monthly Period; and 

  
 5 

 (b) the denominator of which is the numerator used in the calculation of the Card Series Floating
Allocation Percentage for such Monthly Period. 
 “Quarterly Excess Spread Percentage” means, with respect to the
December 2014 Distribution Date and each Distribution Date thereafter, the percentage equivalent of a fraction the numerator of which is the sum of the Excess Spread Percentages with respect to the immediately preceding three Monthly Periods
and the denominator of which is three. 
 “Record Date” means, for any Distribution Date, the last Business Day of the
preceding Monthly Period. 
 “Reference Banks” means four major banks in the London interbank market selected by the
Beneficiary. 
 “Required Accumulation Reserve sub-Account Amount” means, with
respect to any Monthly Period during the Accumulation Reserve Funding Period, an amount equal to (i) 0.5% of the Outstanding Dollar Principal Amount of the Class A(2014-1) Notes as of the close of
business on the last day of the preceding Monthly Period or (ii) any other amount designated by the Issuer; provided, however, that if such designation is of a lesser amount, the Note Rating Agencies shall have provided prior
written confirmation that a Ratings Effect will not occur with respect to such change. 
 “Required Subordinated Amount of Class B
Notes” means, for the Class A(2014-1) Notes for any date of determination, an amount equal to the product of (a) the Required Subordinated Percentage of Class B Notes for such Class A(2014-1) Notes on such date of determination and (b) the Adjusted Outstanding Dollar Principal Amount of such Class A(2014-1) Notes on such date of determination;
provided, however, that such an amount shall not exceed the Maximum Subordination Amount of Class B Notes for the Class A(2014-1) Notes; provided further, however, that for
any date of determination on or after the occurrence and during the continuation of a Class A(2014-1) Adverse Event, the Required Subordinated Amount of Class B Notes for the Class A(2014-1) Notes will be the greater of (x) the amount determined above for such date of determination and (y) the amount determined above for the date immediately prior to the date on which such Class A(2014-1) Adverse Event shall have occurred. 
 “Required Subordinated Amount of Class C
Notes” means, for the Class A(2014-1) Notes for any date of determination, an amount equal to the product of (a) the Required Subordinated Percentage of Class C Notes for such Class A(2014-1) Notes on such date of determination and (b) the Adjusted Outstanding Dollar Principal Amount of such Class A(2014-1) Notes on such date of determination;
provided, however, that for any date of determination, unless (i) the Prefunding Target Amount for any Tranche of Card Series Notes on such date of determination is greater than zero or (ii) any prefunded amounts are on
deposit in a Principal Funding sub-Account on such date of determination for any Tranche of Card Series Notes, the Required Subordinated Amount of Class C Notes for the Class
A(2014-1) Notes will not be less than an amount equal to (i) 3.0% of the Initial Dollar Principal Amount of the Class A(2014-1) Notes, minus (ii) the
Required Subordinated Amount of Class D Notes for the Class 

  
 6 

 
A(2014-1) Notes; provided further, however, that for any date of determination on or after the occurrence and during the continuation
of a Class A(2014-1) Adverse Event, the Required Subordinated Amount of Class C Notes for the Class A(2014-1) Notes will be the greater of (x) the amount determined
above for such date of determination, (y) the amount determined above for the date immediately prior to the date on which such Class A(2014-1) Adverse Event shall have occurred and (z) unless
(i) the Prefunding Target Amount for any Tranche of Card Series Notes on such date of determination is greater than zero or (ii) any prefunded amounts are on deposit in a Principal Funding
sub-Account on such date of determination for any Tranche of Card Series Notes, the amount determined pursuant to the preceding proviso. 

“Required Subordinated Amount of Class D Notes” means, for the Class A(2014-1) Notes
for any date of determination, an amount equal to the product of (a) the Required Subordinated Percentage of Class D Notes for such Class A(2014-1) Notes on such date of determination and (b) the
Adjusted Outstanding Dollar Principal Amount of such Class A(2014-1) Notes on such date of determination; provided, however, that for any date of determination, unless (i) the Prefunding
Target Amount for any Tranche of Card Series Notes on such date of determination is greater than zero or (ii) any prefunded amounts are on deposit in a Principal Funding sub-Account on such date of
determination for any Tranche of Card Series Notes, the Required Subordinated Amount of Class D Notes for the Class A(2014-1) Notes will not be less than an amount equal to 1.2049% of the Initial Dollar
Principal Amount of the Class A(2014-1) Notes, provided further, however, that for any date of determination on or after the occurrence and during the continuation of a Class A(2014-1) Adverse Event, the Required Subordinated Amount of Class D Notes for the Class A(2014-1) Notes will be the greatest of (x) the amount determined above for such
date of determination, (y) the amount determined above for the date immediately prior to the date on which such Class A(2014-1) Adverse Event shall have occurred and (z) unless (i) the
Prefunding Target Amount for any Tranche of Card Series Notes on such date of determination is greater than zero or (ii) any prefunded amounts are on deposit in a Principal Funding sub-Account on such
date of determination for any Tranche of Card Series Notes, the amount determined pursuant to the preceding proviso. 
 “Required
Subordinated Percentage of Class B Notes” means, for the Class A(2014-1) Notes, 10.8434%, subject to adjustment in accordance with Section 2.02. 

“Required Subordinated Percentage of Class C Notes” means, for the Class A(2014-1)
Notes, 8.4338%, subject to adjustment in accordance with Section 2.02. 
 “Required Subordinated Percentage of Class D
Notes” means, for the Class A(2014-1) Notes, 1.2049%, subject to adjustment in accordance with Section 2.02. 

“Reuters Screen LIBOR01 Page” means the display page currently so designated on the Reuters Monitor Money Rates (or such
other page as may replace that page on that service, or such other service as may be nominated as the information vendor, for the purpose of displaying comparable rates or prices). 

“Stated Principal Amount” means $950,000,000. 

  
 7 

 Section 1.02. Governing Law. THIS TERMS DOCUMENT WILL BE CONSTRUED IN ACCORDANCE
WITH AND GOVERNED BY THE LAWS OF THE STATE OF NEW YORK, INCLUDING SECTION 5-1401 OF THE GENERAL OBLIGATION LAW, WITHOUT REFERENCE TO ITS CONFLICT OF LAW PROVISIONS AND THE OBLIGATIONS, RIGHTS AND REMEDIES OF
THE PARTIES HEREUNDER SHALL BE DETERMINED IN ACCORDANCE WITH SUCH LAWS. 
 Section 1.03. Counterparts. This Terms Document
may be executed in any number of counterparts, each of which so executed will be deemed to be an original, but all such counterparts will together constitute but one and the same instrument. 

Section 1.04. Ratification of Indenture, Asset Pool 1 Supplement and Indenture Supplement. As supplemented by this Terms
Document, each of the Indenture, the Asset Pool 1 Supplement and the Indenture Supplement is in all respects ratified and confirmed and the Indenture as so supplemented by the Asset Pool 1 Supplement as so supplemented by the Indenture Supplement as
so supplemented and this Terms Document shall be read, taken and construed as one and the same instrument. 
 [END OF ARTICLE I] 

  
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 ARTICLE II 

The Class A(2014-1) Notes 

Section 2.01. Creation and Designation. There is hereby created a tranche of Card Series Class A Notes to be issued
pursuant to the Indenture, the Asset Pool 1 Supplement and the Indenture Supplement to be known as the “Card Series Class A(2014-1) Notes.” 

Section 2.02. Adjustments to Required Subordinated Percentages. 

(a) On any date, the Issuer may change the Required Subordinated Percentage of Class B Notes or the Required Subordinated Percentage of Class
C Notes, in each case for the Class A(2014-1) Notes, without the consent of any Noteholders or any Note Rating Agencies, provided that, after giving effect to such change, (x) the sum of the Required
Subordinated Percentage of Class B Notes and the Required Subordinated Percentage of Class C Notes, in each case, for the Class A(2014-1) Notes after giving effect to such change is equal to or greater
than the sum of the Required Subordinated Percentage of Class B Notes and the Required Subordinated Percentage of Class C Notes, in each case, for the Class A(2014-1) Notes immediately prior to giving effect
to such change and (y) the Required Subordinated Amount of Class B Notes for the Class A(2014-1) Notes does not exceed the Maximum Subordinated Amount of Class B Notes. 

(b) On any date, the Issuer may change the Required Subordinated Percentage of Class B Notes, the Required Subordinated Percentage of Class C
Notes or the Required Subordinated Percentage of Class D Notes, in each case for the Class A(2014-1) Notes, such that after giving effect to all changes to such percentages on such date the sum of the Required
Subordinated Percentage of Class B Notes, the Required Subordinated Percentage of Class C Notes and the Required Subordinated Percentage of Class D Notes, in each case, for the Class A(2014-1) Notes after
giving effect to such change is less than the sum of the Required Subordinated Percentage of Class B Notes, the Required Subordinated Percentage of Class C Notes and the Required Subordinated Percentage of Class D Notes, in each case, for the Class A(2014-1) Notes immediately prior to giving effect to such change, without the consent of any Noteholders, provided that the Issuer has (i) received written confirmation from each Note Rating Agency that has
rated any Outstanding Notes of the Card Series that the change in such percentage will not result in a Ratings Effect with respect to any Outstanding Notes and (ii) delivered to the Indenture Trustee and the Note Rating Agencies a Master Trust
Tax Opinion for each Master Trust and an Issuer Tax Opinion. 

  
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 Section 2.03. Interest Payment. 

(a) For each Interest Payment Date, the amount of interest due with respect to the Class A(2014-1)
Notes shall be an amount equal to the product of (i)(A) a fraction, the numerator of which is the actual number of days in the related Interest Period and the denominator of which is 360, times (B) the Note Interest Rate in effect
with respect to such related Interest Period times (ii) the Outstanding Dollar Principal Amount of the Class A(2014-1) Notes determined as of the Record Date preceding the related Distribution
Date. Any interest on the Class A(2014-1) Notes will be calculated on the basis of the actual number of days in the related Interest Period and a 360-day year. 

(b) Pursuant to Section 3.03 of the Indenture Supplement, on each Distribution Date, the Indenture Trustee shall deposit into the
Class A(2014-1) Interest Funding sub-Account the portion of Card Series Finance Charge Amounts allocable to the Class A(2014-1)
Notes. 
 Section 2.04. Calculation Agent; Determination of LIBOR. 

(a) The Issuer hereby agrees that for so long as any Class A(2014-1) Notes are Outstanding, there
shall at all times be an agent appointed to calculate LIBOR for each Interest Period (the “Calculation Agent”). The Issuer hereby initially appoints the Indenture Trustee as the Calculation Agent for purposes of determining LIBOR
for each Interest Period. The Calculation Agent may be removed by the Issuer at any time. If the Calculation Agent is unable or unwilling to act as such or is removed by the Issuer, or if the Calculation Agent fails to determine LIBOR for an
Interest Period, the Issuer shall promptly appoint a replacement Calculation Agent that does not control or is not controlled by or under common control with the Issuer or its Affiliates. The Calculation Agent may not resign its duties, and the
Issuer may not remove the Calculation Agent, without a successor having been duly appointed. For the avoidance of doubt, Sections 703 and 707 of the Indenture shall inure to the benefit of the Calculation Agent. 

(b) On each LIBOR Determination Date, the Calculation Agent shall determine LIBOR on the basis of the rate for deposits in United States
dollars for a three-month period which appears on Reuters Screen LIBOR01 Page as of 11:00 a.m., London time, on such date; provided, however, that, if an Early Redemption Event with respect to the
Class A(2014-1) Notes or an Event of Default of the Class A(2014-1) Notes occurs, LIBOR shall be, as of any LIBOR Determination Date occurring on or after such
Early Redemption Event or such Event of Default, the rate for deposits in United States dollars for a one-month period which appears on Reuters Screen LIBOR01 Page as of 11:00 a.m., London time, on such date. If such rate does not appear on Reuters
Screen LIBOR01 Page, the rate for that LIBOR Determination Date shall be determined on the basis of the rates at which deposits in United States dollars are offered by the Reference Banks at approximately 11:00 a.m., London time, on that day to
prime banks in the London interbank market for a three-month period; provided, however, that, if an Early Redemption Event with respect to the Class A(2014-1) Notes or an Event of Default of the
Class A(2014-1) Notes occurs and such rate does not appear on Reuters Screen LIBOR01 Page, the rate for that LIBOR Determination Date shall be determined on the basis of the rates at which deposits in the
United States dollars are offered by the Reference Banks, at approximately 11:00 a.m., London time, on that day to prime banks in the London interbank market for a one-month period. The Calculation Agent shall request the principal London office of
each of the Reference Banks to provide a quotation of its rate. If at least two such quotations are provided, the rate for 

  
 10 

 
that LIBOR Determination Date shall be the arithmetic mean of such quotations. If fewer than two quotations are provided as requested, the rate for that LIBOR Determination Date will be the
arithmetic mean of the rates quoted by four major banks in New York City, selected by the Beneficiary, at approximately 11:00 a.m., New York City time, on that day for loans in United States dollars to leading European banks for a three-month
period; provided, however, that, if an Early Redemption Event with respect to the Class A(2014-1) Notes or an Event of Default of the Class A(2014-1) Notes
occurs and if fewer than two quotations are provided, the rate for that LIBOR Determination Date will be the arithmetic mean of the rates quoted by four major banks in New York City, selected by the Beneficiary, at approximately 11:00a.m., New York
City time, on that day for loans in United States dollars to leading European banks for a one-month period. 
 LIBOR for the first Interest
Period is determined by straight-line interpolation, based on the actual number of days in the first Interest Period from the Issuance Date to but excluding April 15, 2014, between two rates determined in accordance with the preceding
paragraph, one of which will be determined for a maturity of two (2) months and one of which will be determined for a maturity of three (3) months. 

(c) The Note Interest Rate applicable to the then current and the immediately preceding Interest Periods may be obtained by telephoning the
Indenture Trustee at its corporate trust office at (800) 254-2826 or such other telephone number as shall be designated by the Indenture Trustee for such purpose by prior written notice by the Indenture Trustee to each Noteholder from time to
time. 
 (d) On each LIBOR Determination Date, the Calculation Agent shall send to the Indenture Trustee, the Issuer, the Beneficiary and
the Servicer, by facsimile transmission or electronic transmission, notification of LIBOR for the following Interest Period. 

Section 2.05. Payments of Interest and Principal. 

(a) Any installment of interest or principal, if any, payable on any Class A(2014-1) Note which is
punctually paid or duly provided for by the Issuer and the Indenture Trustee on the applicable Interest Payment Date or Principal Payment Date shall be paid by the Paying Agent to the Person in whose name such Class
A(2014-1) Note (or one or more Predecessor Notes) is registered on the Record Date, by wire transfer of immediately available funds to such Person’s account as has been designated by written instructions
received by the Paying Agent from such Person not later than the close of business on the third Business Day preceding the date of payment or, if no such account has been so designated, by check mailed
first-class, postage prepaid to such Person’s address as it appears on the Note Register on such Record Date, except that with respect to Notes registered on the Record Date in the name of the nominee of
Cede & Co., payment shall be made by wire transfer in immediately available funds to the account designated by such nominee. 
 (b)
The right of the Class A(2014-1) Noteholders to receive payments from the Issuer will terminate on the first Business Day following the Class A(2014-1) Termination Date.

  
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 Section 2.06. Form of Delivery of Class
A(2014-1) Notes; Depository; Denominations. 
 (a) The Class
A(2014-1) Notes shall be delivered in the form of a global Registered Note as provided in Sections 202 and 301(i) of the Indenture, respectively. 

(b) The Depository for the Class A(2014-1) Notes shall be The Depository Trust Company, and the Class A(2014-1) Notes shall initially be registered in the name of Cede & Co., its nominee. 
 (c) The
Class A(2014-1) Notes will be issued in minimum denominations of $100,000 and integral multiples of $1,000 in excess of that amount. 

Section 2.07. Delivery and Payment for the Class A(2014-1) Notes. The Issuer shall
execute and deliver the Class A(2014-1) Notes to the Indenture Trustee for authentication, and the Indenture Trustee shall deliver the Class A(2014-1) Notes when
authenticated, each in accordance with Section 303 of the Indenture. 
 Section 2.08. Targeted Deposits to the
Accumulation Reserve Account. The deposit targeted to be made to the Accumulation Reserve Account for any Monthly Period during the Accumulation Reserve Funding Period will be an amount equal to the Required Accumulation Reserve sub-Account Amount. 
 [END OF ARTICLE II] 

  
 12 

 IN WITNESS WHEREOF, the parties hereto have caused this Terms Document to be duly executed, all
as of the day and year first above written. 
  

			
	CAPITAL ONE MULTI-ASSET EXECUTION TRUST,
		
	By:	 	DEUTSCHE BANK TRUST COMPANY DELAWARE, not in its individual capacity, but solely as Owner Trustee on behalf of the Trust
		
	By:	 	/s/ Diana Vasconez
		 	Name:  Diana Vasconez
		 	Title:    Attorney-in-fact
		
	By:	 	/s/ Louis Bodi
		 	Name: Louis Bodi
		 	Title: ATTORNEY-IN-FACT

  

			
	THE BANK OF NEW YORK MELLON, as Indenture Trustee and not in its individual capacity
		
	By:	 	/s/ Leslie Morales
		 	Name: Leslie Morales
		 	Title: Vice President

  
 [Class A(2014-1) Terms
Document]EX-4.1

 Exhibit 4.1 
 FIFTH AMENDED AND RESTATED 
 REGISTRATION RIGHTS AGREEMENT 

by and among 

MACROGENICS, INC., 
 THE FOUNDERS, 
 and 

THE INVESTORS 

February 3, 2014 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
			
	 1.
	 	Certain Definitions	  	 	1	  
			
	 2.
	 	Restrictive Legend	  	 	2	  
			
	 3.
	 	Notice of Proposed Transfer	  	 	2	  
			
	 4.
	 	Required Registration	  	 	3	  
			
	 5.
	 	Incidental Registration	  	 	5	  
			
	 6.
	 	Registration on Form S-3	  	 	5	  
			
	 7.
	 	Registration Procedures	  	 	6	  
			
	 8.
	 	Expenses	  	 	8	  
			
	 9.
	 	Indemnification and Contribution	  	 	8	  
			
	 10.
	 	Changes in Common Stock or Preferred Stock	  	 	10	  
			
	 11.
	 	Rule 144 Reporting	  	 	10	  
			
	 12.
	 	Representations and Warranties of the Company	  	 	11	  
			
	 13.
	 	Binding Arbitration	  	 	11	  
			
	 14.
	 	Miscellaneous	  	 	13	  

  
 i 

 MACROGENICS, INC. 

FIFTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 
 THIS FIFTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT, dated February 3, 2014 (this “Agreement”), is made by and among (i) MacroGenics, Inc., a Delaware corporation (the
“Company”), (ii) those parties identified as Founders on Exhibit A (the “Founders”), and (iii) the parties listed on Exhibit B hereto (the “Existing Investors”), the parties
listed on Exhibit C hereto (the “Series D Investors”), the parties listed on Exhibit D hereto (the “New Investors,”) (collectively, the “Investors”). 

In consideration of the mutual promises and obligations contained herein, the parties hereto agree as follows: 

1. Certain Definitions. As used in this Agreement, the following terms shall have the following respective meanings: 

“Additional Restricted Stock” shall mean the shares of Common Stock (the “Additional Conversion
Shares”) issued upon conversion of the 5,000,000 Preferred Shares (the “Additional Preferred Stock”) issued and sold pursuant to that certain Stock Purchase Agreement dated as of October 27, 2003, by and between the
Company and Genzyme Corporation, excluding Additional Conversion Shares which (a) have been registered under the Securities Act pursuant to an effective registration statement filed thereunder and disposed of in accordance with the registration
statement covering them, (b) have been publicly sold pursuant to Rule 144 under the Securities Act, or (c) may be sold without volume limitation or other restrictions on transfer under Rule 144 under the Securities Act. 

“Commission” shall mean the Securities and Exchange Commission, or any other federal agency at the time administering
the Securities Act. 
 “Common Stock” shall mean the Common Stock, $0.01 par value per share, of the Company,
as constituted as of the date of this Agreement. 
 “Conversion Shares” shall mean shares of Common Stock
issued upon conversion of the Preferred Shares. 
 “Exchange Act” shall mean the Securities Exchange Act of
1934, as amended, or any similar federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 
 “Preferred Shares” shall mean the shares of Series A-1 Convertible Preferred Stock, $0.01 par value per share, the shares of Series A-2 Convertible Preferred Stock, $0.01 par value per
share, the shares of Series B-1 Convertible Preferred Stock, par value $0.01 per share, the shares of Series C Convertible Preferred Stock, $0.01 par value per share, the shares of Series D Convertible Preferred Stock, $0.01 par value per share, and
the shares of Series D-2 Convertible Preferred Stock, $0.01 par value per share. 

  

- 1 - 

 “Preferred Stock” shall mean the Series A-1 Convertible Preferred Stock,
$0.01 par value per share, the Series A-2 Convertible Preferred Stock, $0.01 par value per share, the Series B-1 Convertible Preferred Stock, par value $0.01 per share, the Series C Convertible Preferred Stock, $0.01 par value per share, the Series
D Convertible Preferred Stock, $0.01 par value per share, and the Series D-2 Convertible Preferred Stock, $0.01 par value per share. 
 “Registration Expenses” shall mean the expenses so described in Section 8. 
 “Restricted Stock” shall mean the Conversion Shares, excluding (i) Additional Conversion Shares and (ii) Conversion Shares which (a) have been registered under the
Securities Act pursuant to an effective registration statement filed thereunder and disposed of in accordance with the registration statement covering them, (b) have been publicly sold pursuant to Rule 144 under the Securities Act, or
(c) may be sold without volume limitation or other restrictions on transfer under Rule 144 under the Securities Act. For purposes of Section 5 hereof, and all other provisions of this Agreement applicable to any registration covered by
Section 5 hereof, Restricted Stock shall also include all Common Stock then held by the Founders and the University. 

“Securities Act” shall mean the Securities Act of 1933, as amended, or any similar federal statute, and the rules and
regulations of the Commission thereunder, all as the same shall be in effect at the time. 
 “Selling Expenses”
shall mean the expenses so described in Section 8. 
 “University” shall mean the Board of Regents of the
University of Texas System. 
 2. Restrictive Legend. Each certificate representing Preferred Shares or Conversion Shares
shall, except as otherwise provided in this Section 2 or in Section 3, be stamped or otherwise imprinted with a legend substantially in the following form: 
 “THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE OFFERED, SOLD OR
OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT AND IN COMPLIANCE WITH SUCH STATE SECURITIES LAWS OR UNLESS THE ISSUER HAS RECEIVED OR WAIVED AN OPINION OF LEGAL COUNSEL SATISFACTORY TO THE ISSUER
AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED AND SUCH COMPLIANCE IS AVAILABLE.” 
 A certificate shall not bear such legend if in
the opinion of counsel reasonably satisfactory to the Company the securities represented thereby may be publicly sold without registration under the Securities Act and any applicable state securities laws. 

3. Notice of Proposed Transfer. Prior to any proposed transfer of any Preferred Shares or Conversion Shares (other than under the
circumstances described in Sections 4, 5 or 6), the holder thereof shall give written notice to the Company of its intention to effect such transfer. Each such notice shall describe the manner of the proposed transfer and, if requested by the

  

- 2 - 

 
Company, shall be accompanied by an opinion of counsel reasonably satisfactory to the Company to the effect that the proposed transfer may be effected without registration under the Securities
Act and any applicable state securities laws, whereupon the holder of such stock shall be entitled to transfer such stock in accordance with the terms of its notice; provided, however, that no such opinion of counsel shall be required
for (i) a transfer to one or more partners or members of the transferor (in the case of a transferor that is a partnership or a limited liability company, respectively) or to an affiliated corporation (in the case of a transferor that is a
corporation) or (ii) a transfer by any Investor to an affiliate or an entity controlled by, controlling or under common control with such Investor. Each certificate for Preferred Shares or Conversion Shares transferred as above provided shall
bear the legend set forth in Section 2, except that such certificate shall not bear such legend if (A) such transfer is in accordance with the provisions of Rule 144 (or any other rule permitting public sale without registration under the
Securities Act) or (B) the opinion of counsel referred to above is to the further effect that the transferee and any subsequent transferee (other than an affiliate of the Company) would be entitled to transfer such securities in a public sale
without registration under the Securities Act. The restrictions provided for in this Section 3 shall not apply to securities which are not required to bear the legend prescribed by Section 2 in accordance with the provisions of that
Section. 
 4. Required Registration  

(a) At any time after the earliest of (i) 180 days after any registration statement covering a public offering
of securities of the Company under the Securities Act shall have become effective, (ii) 180 days after the Company shall have become a reporting company under Section 12 of the Exchange Act, and (iii) the second (2nd) anniversary of May 16, 2006, the holders of Restricted
Stock (other than the New Investors and the Series D Investors) constituting at least 40% of the total shares of Restricted Stock then outstanding (other than the shares of Restricted Stock held by the New Investors and the Series D Investors) may
request the Company to register under the Securities Act all or any portion of the shares of Restricted Stock held by such requesting holder or holders for sale in the manner specified in such notice, provided that the reasonably anticipated
aggregate price to the public of such public offering would exceed $5,000,000. 
 (b) At any time after the
earliest of (i) 180 days after any registration statement covering a public offering of securities of the Company under the Securities Act shall have become effective, (ii) 180 days after the Company shall have become a reporting company
under Section 12 of the Exchange Act, and (iii) the second (2nd) anniversary of July 15, 2008, New Investors and Series D Investors constituting at least 40% of the total shares of Restricted Stock then collectively held by the New Investors and the Series
D Investors, may request the Company to register under the Securities Act all or any portion of the shares of Restricted Stock held by such requesting holder or holders for sale in the manner specified in such notice, provided that the
reasonably anticipated aggregate price to the public of such public offering would exceed $25,000,000. 
 (c) For purposes of
this Section 4 and Sections 5, 6, 13(a) and 13(d), the term “Restricted Stock” shall be deemed to include the number of shares of Restricted Stock that would be issuable to a holder of Preferred Shares upon conversion of all
Preferred Shares held by such holder at such time; provided, however, that the only securities which the Company shall be 

  

- 3 - 

 
required to register pursuant hereto shall be shares of Common Stock, and provided, further, however, that, in any underwritten public offering contemplated by this
Section 4 or Sections 5 and 6, the holders of Preferred Shares shall be entitled to sell such Preferred Shares to the underwriters for conversion and sale of the shares of Common Stock issued upon conversion thereof. Notwithstanding anything to
the contrary contained herein, the Company shall not be obligated under this Section 4: (i) within 180 days after the effective date of a registration statement filed by the Company in connection with the Company’s initial public
offering, or (ii) within 180 days after the effective date of a registration statement filed by the Company covering a firm commitment underwritten public offering in which the holders of Restricted Stock shall have been entitled to join
pursuant to Section 5 or 6 and in which there shall have been effectively registered all shares of Restricted Stock as to which registration shall have been requested. 
 (d) Following receipt of any notice under this Section 4, the Company shall immediately notify all holders of Restricted Stock and Additional Restricted Stock from whom notice has not been received
and shall use its best efforts to register under the Securities Act, for public sale in accordance with the method of disposition specified in such notice from requesting holders, the number of shares of Restricted Stock and Additional Restricted
Stock specified in such notice (and in all notices received by the Company from other holders within 30 days after the giving of such notice by the Company). If such method of disposition shall be an underwritten public offering, the Company may
designate the managing underwriter of such offering, subject to the approval of the holders of a majority of the shares of Restricted Stock to be sold in such offering, which approval shall not be unreasonably withheld or delayed. The Company shall
be obligated to register Restricted Stock and Additional Restricted Stock pursuant to this Section 4 on one (1) occasion only; provided, however, that such obligation shall be deemed satisfied only when a registration
statement covering all shares of Restricted Stock and Additional Restricted Stock specified in notices received as aforesaid, for sale in accordance with the method of disposition specified by the requesting holders, shall have become effective and,
if such method of disposition is a firm commitment underwritten public offering, all such shares shall have been sold pursuant thereto. Notwithstanding the foregoing, the Company may delay a request for registration pursuant to this Section 4
if, within 30 days following the receipt of any notice requesting registration in accordance with this Section 4, the Company notifies the holders of Restricted Stock and Additional Restricted Stock that the Company intends to file a
registration statement with the Commission relating to an initial public offering within 90 days of such notice by the Company to the holders of Restricted Stock and Additional Restricted Stock and provided the Company shall, in good faith, use
reasonable efforts to cause such registration statement to become effective; provided, however, that the Company may exercise such right to delay a request for registration under such circumstances not more than once in any 12-month
period. 
 (e) The Company shall be entitled to include in any registration statement referred to in this Section 4, for
sale in accordance with the method of disposition specified by the requesting holders, shares of Common Stock to be sold by the Company for its own account, except as and to the extent that, in the opinion of the managing underwriter (if such method
of disposition shall be an underwritten public offering), such inclusion would adversely affect the marketing of the Restricted Stock and Additional Restricted Stock to be sold. 

  

- 4 - 

 5. Incidental Registration. If the Company at any time proposes to register any of
its securities under the Securities Act for sale to the public, whether for its own account or for the account of other security holders or both (except with respect to registration statements on Forms S-4, S-8 or another form not available for
registering the Restricted Stock or Additional Restricted Stock for sale to the public), each such time it will give written notice to all holders of outstanding Restricted Stock and Additional Restricted Stock of its intention so to do. Upon the
written request of any such holder, received by the Company within 30 days after the giving of any such notice by the Company, to register any of its Restricted Stock or Additional Restricted Stock, the Company shall cause the Restricted Stock and
Additional Restricted Stock as to which registration shall have been so requested to be included in the securities to be covered by the registration statement proposed to be filed by the Company, all to the extent requisite to permit the sale or
other disposition by the holder of such Restricted Stock or Additional Restricted Stock so registered. In the event that any registration pursuant to this Section 5 shall be, in whole or in part, an underwritten public offering of Common Stock,
the number of shares of Restricted Stock and Additional Restricted Stock to be included in such an underwriting may be reduced if and to the extent that the managing underwriter shall be of the opinion that such inclusion would adversely affect the
marketing of the securities to be sold by the Company therein, provided, however, that such number of shares of Restricted Stock and Additional Restricted Stock shall not be reduced if any shares are to be included in such underwriting
for the account of any person other than the Company or holders of Restricted Stock or holders of Additional Restricted Stock, and provided, further, however, that, except in the case of the Company’s initial public offering, in
no event may less than twenty-five percent (25%) of the total number of shares of Common Stock to be included in such underwriting be made available for shares of Restricted Stock. In the event of such reduction, the Company shall so advise all
holders of Restricted Stock and Additional Restricted Stock requesting registration, and the number of shares that are entitled to be included in the registration and underwriting shall be allocated in the following manner. First, the number of
shares that may be included in such registration and underwriting shall be allocated among all Investors who have requested registration in proportion, as nearly as practicable, to the respective number of shares of Restricted Stock and Additional
Restricted Stock held by such Investors at the time of the Company’s notice under this Section 5. No shareholder of the Company shall be granted registration rights which would reduce the number of shares includable by the holders of the
Restricted Stock and Additional Restricted Stock in such registration without the consent of the holders of at least two-thirds of the Restricted Stock and Additional Restricted Stock. If any Investor would thus be entitled to include more
securities than such Investor requested to be registered, the excess shall be allocated among the other requesting Investors pro rata in the manner described in the preceding sentence. Second, once all shares of Restricted Stock and
Additional Restricted Stock requested by the Investors to be registered have been included in such registration and underwriting, the Founders and the University shall participate in the offering, pro rata based upon their total ownership of
shares of Restricted Stock. Notwithstanding the foregoing provisions, the Company may withdraw any registration statement referred to in this Section 5 without thereby incurring any liability to the holders of Restricted Stock or Additional
Restricted Stock. 
 6. Registration on Form S-3. If at any time (a)(i) a holder or holders of Restricted Stock
(other than the Series D Investors) request that the Company file a registration statement on Form S-3 or any successor thereto for a public offering of all or any portion of the shares of 

  

- 5 - 

 
Restricted Stock held by such requesting holder or holders, the reasonably anticipated aggregate price to the public of which would exceed $1,000,000; or (ii) one or more of the Series D
Investors request that the Company file a registration statement on Form S-3 or any successor thereto for a public offering of all or any portion of the shares of Restricted Stock held by such requesting holder or holders, the reasonably anticipated
aggregate price to the public of which would exceed $5,000,000; and (b) the Company is a registrant entitled to use Form S-3 or any successor thereto to register such shares, then the Company shall use its best efforts to register under
the Securities Act on Form S-3 or any successor thereto, for public sale in accordance with the method of disposition specified in such notice, the number of shares of Restricted Stock specified in such
notice. Whenever the Company is required by this Section 6 to use its best efforts to effect the registration of Restricted Stock, each of the procedures and requirements of Section 4 (including, but not limited to, the requirement that
the Company notify all holders of Restricted Stock and Additional Restricted Stock from whom notice has not been received and provide them with the opportunity to participate in the offering) shall apply to such registration; provided,
however, that the requirements contained in Section 4(a) and Section 4(b) shall not apply to any registration on Form S-3 which may be requested and obtained under this Section 6. 

7. Registration Procedures. If and whenever the Company is required by the provisions of Sections 4, 5 or 6 to use its best
efforts to effect the registration of any shares of Restricted Stock and/or Additional Restricted Stock under the Securities Act, the Company will, as expeditiously as possible: 

(a) prepare and file (in the case of a registration pursuant to Section 4 or Section 6, within 60 days of receipt by the
Company of the applicable request for registration) with the Commission a registration statement (which, in the case of an underwritten public offering pursuant to Section 4, shall be on Form S-1 or other form of general applicability
satisfactory to the managing underwriter selected as therein provided) with respect to such securities and use its best efforts to cause such registration statement to become and remain effective for the period of the distribution contemplated
thereby (determined as hereinafter provided); 
 (b) prepare and file with the Commission such amendments and supplements to
such registration statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective for the period specified in subparagraph (a) above and comply with the provisions of the Securities
Act (including the antifraud provisions thereof) with respect to the disposition of all Restricted Stock and Additional Restricted Stock covered by such registration statement in accordance with the sellers’ intended method of disposition set
forth in such registration statement for such period; 
 (c) furnish to each seller of Restricted Stock and Additional
Restricted Stock and to each underwriter such number of copies of the registration statement and the prospectus included therein (including each preliminary prospectus) as such persons reasonably may request in order to facilitate the public sale or
other disposition of the Restricted Stock and Additional Restricted Stock covered by such registration statement; 
 (d) use its
best efforts to register or qualify the Restricted Stock and Additional Restricted Stock covered by such registration statement under the securities or “blue 

  

- 6 - 

 
sky” laws of such jurisdictions as the sellers of Restricted Stock and Additional Restricted Stock or, in the case of an underwritten public offering, the managing underwriter reasonably
shall request, provided, however, that the Company shall not for any such purpose be required to qualify generally to transact business as a foreign corporation in any jurisdiction where it is not so qualified or to consent to general
service of process in any such jurisdiction; 
 (e) use its best efforts to list the Restricted Stock and Additional Restricted
Stock covered by such registration statement with any securities exchange or automated quotation system on which the Common Stock of the Company is then listed; 
 (f) immediately notify each seller of Restricted Stock and Additional Restricted Stock and each underwriter under such registration statement, at any time when a prospectus relating thereto is required to
be delivered under the Securities Act, of the happening of any event of which the Company has knowledge as a result of which the prospectus contained in such registration statement, as then in effect, includes an untrue statement of a material fact
or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing; and 
 (g) make available for inspection by each seller of Restricted Stock and Additional Restricted Stock, any underwriter participating in any distribution pursuant to such registration statement, and any
attorney, accountant or other agent retained by such seller or underwriter, all financial and other records, pertinent corporate documents and properties of the Company, and cause the Company’s officers, directors and employees to supply all
information reasonably requested by any such seller, underwriter, attorney, accountant or agent in connection with such registration statement. 
 For purposes of Section 7(a) and 7(b) and of Section 4(c), the period of distribution of Restricted Stock and Additional Restricted Stock in a firm commitment underwritten public offering shall
be deemed to extend until each underwriter has completed the distribution of all securities purchased by it, and the period of distribution of Restricted Stock and Additional Restricted Stock in any other registration shall be deemed to extend until
the earlier of the sale of all Restricted Stock and Additional Restricted Stock covered thereby and 180 days after the effective date thereof. 
 In connection with each registration hereunder, the sellers of Restricted Stock and Additional Restricted Stock will furnish to the Company in writing such information with respect to themselves and the
proposed distribution by them as reasonably shall be necessary in order to assure compliance with federal and applicable state securities laws. 
 In connection with each registration pursuant to Sections 4, 5 or 6 covering an underwritten public offering, the Company and each selling holder of Restricted Stock and Additional Restricted Stock
agree to enter into a written agreement with the managing underwriter selected in the manner herein provided in such form and containing such provisions as are customary in the securities business for such an arrangement between such underwriter and
companies of the Company’s size and investment stature. 

  

- 7 - 

 (h) Notwithstanding the other provisions of this Agreement, the Company’s obligation to
file a registration statement, or cause such registration statement to become and remain effective, may be suspended on one (1) occasion in any 12-month period for a period not to exceed 90 days if there exists at the time material non-public
information relating to the Company and in the good faith opinion of the Board of Directors of the Company it would be seriously detrimental to the Company for such registration statement to become effective. In addition, the parties hereto
acknowledge the Company may notify holders and suspend use of an effective registration statement for a similar period. 
 8.
Expenses. All expenses incurred by the Company in complying with Sections 4, 5 and 6, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel and independent public
accountants for the Company, fees and expenses (including counsel fees) incurred in connection with complying with state securities or “blue sky” laws, fees of the Financial Industry Regulatory Authority, transfer taxes, fees of transfer
agents and registrars, costs of insurance and fees and disbursements of one special counsel for the sellers of Restricted Stock and Additional Restricted Stock (such special counsel’s fees not to exceed $40,000 in the aggregate for each such
registration), but excluding any Selling Expenses, are called “Registration Expenses.” All underwriting discounts and selling commissions applicable to the sale of Restricted Stock and Additional Restricted Stock are called “Selling
Expenses.” 
 The Company will pay all Registration Expenses in connection with each registration statement under Sections 4, 5 or 6. All
Selling Expenses in connection with each registration statement under Sections 4, 5 or 6 shall be borne by the participating sellers in proportion to the number of shares sold by each, or by such participating sellers other than the Company (except
to the extent the Company shall be a seller) as they may agree. 
 9. Indemnification and Contribution. 

(a) In the event of a registration of any of the Restricted Stock or Additional Restricted Stock under the Securities Act pursuant to
Sections 4, 5 or 6, the Company will indemnify and hold harmless each seller of such Restricted Stock and Additional Restricted Stock thereunder, each underwriter of such Restricted Stock and Additional Restricted Stock thereunder and each other
person, if any, who controls such seller or underwriter within the meaning of the Securities Act, against any losses, claims, damages or liabilities, joint or several, to which such seller, underwriter or controlling person may become subject under
the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in any
registration statement under which such Restricted Stock or Additional Restricted Stock was registered under the Securities Act pursuant to Sections 4, 5 or 6, any preliminary prospectus or final prospectus contained therein, or any amendment
or supplement thereof, or arise out of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and will reimburse each such seller,
each such underwriter and each such controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action as the same are incurred,
provided, however, that the Company will not be liable in any such case if and to the 

  

- 8 - 

 
extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission so made in conformity with
information furnished by any such seller, any such underwriter or any such controlling person in writing specifically for use in such registration statement or prospectus or from a failure of such seller to comply with the prospectus delivery
requirements of the Securities Act if the Company has delivered to such seller any reasonable number of correct or corrected prospectuses requested by such seller. 
 (b) In the event of a registration of any of the Restricted Stock or Additional Restricted Stock under the Securities Act pursuant to Sections 4, 5 or 6, each seller of such Restricted Stock or Additional
Restricted Stock thereunder, severally and not jointly, will indemnify and hold harmless the Company, each person, if any, who controls the Company within the meaning of the Securities Act, each officer of the Company who signs the registration
statement, each director of the Company, each underwriter and each person who controls any underwriter within the meaning of the Securities Act, against all losses, claims, damages or liabilities, joint or several, to which the Company or such
officer, director, underwriter or controlling person may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement
or alleged untrue statement of any material fact contained in the registration statement under which such Restricted Stock or Additional Restricted Stock was registered under the Securities Act pursuant to Sections 4, 5 or 6, any preliminary
prospectus or final prospectus contained therein or any amendment or supplement thereof or arise out of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the
statements therein not misleading and will reimburse the Company and each such officer, director, underwriter and controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such
loss, claim, damage, liability or action, provided, however, that such seller will be liable hereunder in any such case if and only to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue
statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with information pertaining to such seller, as such, furnished in writing to the Company by such seller specifically for use in such
registration statement or prospectus, and provided, further, however, that the liability of each seller hereunder shall be limited to the proportion of any such loss, claim, damage, liability or expense which is equal to the proportion
that the public offering price of the shares sold by such seller under such registration statement bears to the total public offering price of all securities sold thereunder, but not in any event to exceed the proceeds received by such seller from
the sale of Restricted Stock or Additional Restricted Stock covered by such registration statement. 
 (c) Promptly after
receipt by an indemnified party hereunder of notice of the commencement of any action, such indemnified party shall, if a claim in respect thereof is to be made against the indemnifying party hereunder, notify the indemnifying party in writing
thereof, but the omission so to notify the indemnifying party shall not relieve it from any liability which it may have to such indemnified party other than under this Section 9 and shall only relieve it from any liability which it may have to
such indemnified party under this Section 9 if and to the extent the indemnifying party is prejudiced by such omission. In case any such action shall be brought against any indemnified party and it shall notify the indemnifying party of the
commencement thereof, the indemnifying party shall be entitled to participate in and, to the 

  

- 9 - 

 
extent it shall wish, to assume and undertake the defense thereof with counsel satisfactory to such indemnified party, and, after notice from the indemnifying party to such indemnified party of
its election so to assume and undertake the defense thereof, the indemnifying party shall not be liable to such indemnified party under this Section 9 for any legal expenses subsequently incurred by such indemnified party in connection with the
defense thereof other than reasonable costs of investigation and of liaison with counsel so selected, provided, however, that, if the defendants in any such action include both the indemnified party and the indemnifying party and the
indemnified party shall have reasonably concluded that there may be reasonable defenses available to it which are different from or additional to those available to the indemnifying party or if the interests of the indemnified party reasonably may
be deemed to conflict with the interests of the indemnifying party, the indemnified party shall have the right to select a separate counsel and to assume such legal defenses and otherwise to participate in the defense of such action, with the
expenses and fees of such separate counsel and other expenses related to such participation to be reimbursed by the indemnifying party as incurred. 
 (d) If for any reason the indemnification provided for in this Section 9 is held by a court of competent jurisdiction to be unavailable to an indemnified person in respect of any losses, claims,
damages, expenses or liabilities referred to therein, then each indemnifying party under this Section 9, in lieu of indemnifying such indemnified party thereunder, shall contribute to the amount paid or payable by such indemnified party as a
result of such losses, claims, damages, expenses or liabilities in such proportion as is appropriate to reflect the relative fault of the Company, the selling holders of Restricted Stock and Additional Restricted Stock and the underwriters in
connection with the statements or omissions which resulted in such losses, claims, damages, expenses or liabilities, as well as any other relevant equitable considerations. The relative fault of the Company, the selling holders of Restricted Stock
and Additional Restricted Stock and the underwriters shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to
information supplied by the Company, the selling holders of Restricted Stock and Additional Restricted Stock or the underwriters, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such
statement or omission. Notwithstanding the foregoing, (A) no holder will be required to contribute any amount in excess of the public offering price of all such Restricted Stock or Additional Restricted Stock offered by it pursuant to such
registration statement; and (B) no person or entity guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any person or entity who was not guilty of such
fraudulent misrepresentation. 
 10. Changes in Common Stock or Preferred Stock. If, and as often as, there is any change
in the Common Stock or the Preferred Stock by way of a stock split, stock dividend, combination or reclassification, or through a merger, consolidation, reorganization or recapitalization, or by any other means, appropriate adjustment shall be made
in the provisions hereof so that the rights and privileges granted hereby shall continue with respect to the Common Stock or the Preferred Stock as so changed. 
 11. Rule 144 Reporting. With a view to making available the benefits of certain rules and regulations of the Commission which may at any time permit the sale of the Restricted Stock or Additional
Restricted Stock to the public without registration, at all times after 90 days after any registration statement covering a public offering of securities of the Company under the Securities Act shall have become effective, the Company agrees to:

  

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   (a) make and keep public information available, as those terms are understood
and defined in Rule 144 under the Securities Act; 
   (b) use its best efforts to file with the Commission in a
timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act; and 

  (c) furnish to each holder of Restricted Stock or Additional Restricted Stock forthwith upon request a written statement by
the Company as to its compliance with the reporting requirements of such Rule 144 and of the Securities Act and the Exchange Act, a copy of the most recent annual or quarterly report of the Company, and such other reports and documents so filed by
the Company as such holder may reasonably request in availing itself of any rule or regulation of the Commission allowing such holder to sell any Restricted Stock or Additional Restricted Stock without registration. 

12. Representations and Warranties of the Company. The Company represents and warrants to the Investors as follows: 

  (a) The execution, delivery and performance of this Agreement by the Company have been duly authorized by all requisite
corporate action and will not violate any provision of law, any order of any court or other agency of government, the Certificate of Incorporation or By-laws of the Company or any provision of any indenture,
agreement or other instrument to which it or any or its properties or assets is bound, conflict with, result in a breach of or constitute (with due notice or lapse of time or both) a default under any such indenture, agreement or other instrument or
result in the creation or imposition of any lien, charge or encumbrance of any nature whatsoever upon any of the properties or assets of the Company. 
   (b) This Agreement has been duly executed and delivered by the Company and constitutes the legal, valid and binding obligation of the Company, enforceable in accordance with its terms.

 13. Binding Arbitration. 
   (a) Any controversies, disputes, actions, causes of action or other claims between the parties arising out of or relating to this Agreement, or the breach, termination or validity hereof, or
any other matters related thereto (a “Controversy”), whether during the term of this Agreement or otherwise, which are not resolved by mutual agreement within forty-five (45) days of
first written notification by one party to the other parties of the existence of the Controversy (which notification must set forth in reasonable detail the specific points in dispute) shall be finally settled by arbitration before a neutral
arbitrator in accordance with the Commercial Arbitration Rules of the American Arbitration Association (“AAA”) then in effect (modified only as herein expressly provided). The arbitrator shall be experienced with regard to
commercial disputes of the type for which arbitration is being sought. The arbitration shall be before one arbitrator mutually agreed upon by the parties. In the event the parties cannot reach agreement upon an arbitrator, an arbitrator shall be
appointed by the Director of the Washington, 

  

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D.C., office of AAA. Each party must continue to perform their respective obligations under this Agreement despite the existence of the Controversy. The parties agree that the arbitration will be
held in Washington, D.C., or in such other place as the parties may mutually agree upon. The arbitration will be held in accordance with and subject to the procedural rules and applicable requirements and procedures of the District of Columbia. The
arbitrator may enter a default decision against any party who fails to participate in the arbitration proceedings. The decision of the arbitrator on the points in dispute with respect to such Controversy will be final, non-appealable and binding and
judgment on the award may be entered in any court having jurisdiction thereof. The parties agree that this clause has been included to rapidly and inexpensively resolve any Controversy, and that this clause shall be grounds for dismissal of any
court action commenced by any party arising out of or relating to this Agreement or the breach, termination or validity hereof or any other matters relating thereto; provided that nothing in this Section 13 shall limit any party’s right to
bring (i) post-arbitration actions seeking to enforce an arbitration award or (ii) actions seeking injunctive or other similar relief in the event of the breach or threatened breach of any of the
provisions of this Agreement. The parties shall keep confidential, and shall not disclose to any person (except (A) to the extent required by law, and (B) for disclosure to those employees and agents of any such party who have a need to
know and who have been advised of their obligations of confidentiality and non-disclosure hereunder), the existence of any Controversy hereunder, the referral of any such Controversy to arbitration or the status or resolution thereof. 

  (b) The parties hereto agree that the party or parties which are principally prevailing in any such Controversy shall be
entitled to full reimbursement of all out-of-pocket costs incurred by such prevailing party and its affiliates in connection with such Controversy (including reimbursement of all reasonable attorneys’ fees and expenses) and the arbitrator is
hereby empowered to include such reimbursement in any award or determination. In the event that there is no party which is principally prevailing in any such Controversy, the arbitrator will be authorized to apportion its fees and expenses and the
reasonable attorneys’ fees and expenses of the parties as the arbitrator deems appropriate, and in the absence of any such apportionment, the fees and expenses of the arbitrator will be borne equally by all parties involved in such arbitration,
and each party will bear the fees and expenses of its own attorney. 
   (c) With respect to any action or proceeding
which a successful party to the arbitration may wish to bring to enforce any arbitral award or to seek injunctive or other similar relief in the event of the breach or threatened breach of this Agreement, each party irrevocably and unconditionally
(and without limitation): 
 (i) submits to and accepts, for itself and in respect of its assets, generally and unconditionally
the non-exclusive jurisdiction of the courts of the United States and of the State of Delaware; 
 (ii) waives any objection it
may have now or in the future that such action or proceeding has been brought in an inconvenient forum; 
 (iii) agrees that in
any such action or proceeding it will not raise, rely on or claim any immunity (including, without limitation, from suit, judgment, attachment before judgment or otherwise, execution or other enforcement); 

  

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 (iv) waives any right of immunity which it has or its assets may have at any time; and

 (v) consents generally to the giving of any relief or the issue of any process in connection with any such action or
proceeding including, without limitation, the making, enforcement or execution of any order or judgment against any of its property. 
 14. Miscellaneous. 
   (a) All covenants and agreements contained
in this Agreement by or on behalf of any of the parties hereto shall bind and inure to the benefit of the respective successors and assigns of the parties hereto (including without limitation transferees of any Preferred Shares, Restricted Stock or
Additional Restricted Stock), whether so expressed or not, provided, however, that registration rights conferred herein on the holders of Preferred Shares, Restricted Stock or Additional Restricted Stock shall only inure to the benefit
of a transferee of Preferred Shares, Restricted Stock or Additional Restricted Stock if the Company is provided with notice of the transfer and either (i) the transferee acquires 5,500,000 shares (subject to equitable adjustment in the event of
any stock dividend, stock split, combination, reorganization, recapitalization, reclassification or other similar event affecting such shares) or (ii) such transferee is (A) in the case of a party hereto who is a natural person, an
immediate family member or trust for the benefit of such holder or (B) a partner, retired partner, member, retired member, shareholder or affiliate of a party hereto; and provided, further that, upon written notice and with the
written consent of the Company (such consent not to be unreasonably withheld or unduly delayed), the Company shall grant the registration rights conferred herein to any transferee of Preferred Shares, Restricted Stock or Additional Restricted Stock
of at least 3,000,000 shares (subject to equitable adjustment in the event of any stock dividend, stock split, combination, reorganization, recapitalization, reclassification or other similar event affecting such shares). 

  (b) All notices, requests, consents and other communications hereunder shall be in writing and shall be delivered in person,
mailed by certified or registered mail, return receipt requested, or sent by telecopier or telex, addressed as follows: 
 (i)
if to the Company, at the address of its principal office; 
 (ii) if to any other party to this Agreement, at its address on
the records maintained by the Company; 
 (iii) if to any subsequent holder of Preferred Shares, Restricted Stock or Additional
Restricted Stock, to it at such address as may have been furnished to the Company in writing by such holder; 
 or, in any case, at such other
address or addresses as shall have been furnished in writing to the Company (in the case of a holder of Preferred Shares, Restricted Stock or Additional Restricted Stock) or to the holders of Preferred Shares, Restricted Stock or Additional
Restricted Stock (in the case of the Company) in accordance with the provisions of this paragraph. 

  

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   (c) This Agreement shall be governed by and construed in accordance with the
laws of the State of Delaware without giving effect to any choice or conflict of law provision or rule that would cause the application of the laws of any other state. 

  (d) This Agreement may not be amended or modified, and no provision hereof may be waived, without the
written consent of the Company and the Investors holding at least sixty-six and two-thirds percent
(66  2/3%) of the combined outstanding shares of Restricted Stock and Additional Restricted Stock, voting together as a single class. provided that any amendment, modification or waiver to the terms of
Sections 4, 5, or 6 (or a defined term used therein) that occurs after the closing of the Company’s initial public offering shall instead require the written consent of the Company and Investors then holding Restricted Stock and Additional
Restricted Stock representing at least sixty-six and two-thirds percent (66  2/3%) of the combined outstanding shares of Restricted Stock and Additional Restricted Stock voting together as a single
class. Notwithstanding the foregoing, no provision of this Agreement shall be amended, modified or terminated, nor shall the observance of any term of this Agreement be waived, unless such amendment, modification, termination or waiver, as the case
may be, applies in the same material respects to all Investors, unless such affected Investor consents to such amendment, modification, termination or waiver. 
   (e) This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

  (f) The obligations of the Company to register shares of Restricted Stock and Additional Restricted
Stock under Sections 4, 5 or 6 shall terminate on the earlier of (i) the seventh (7th) anniversary of the closing of the Company’s initial public offering, or (ii) the date on which no Investor holds any Restricted Stock or Additional Restricted Stock. 

  (g) In connection with the initial underwritten public offering of securities of the Company, each holder (including the
Founders and the University) of Restricted Stock or Additional Restricted Stock who is a party to this Agreement agrees not to sell, assign, transfer, pledge, hypothecate, mortgage, encumber or otherwise dispose any shares of Restricted Stock,
Additional Restricted Stock or any other shares of Common Stock then held by such holder (other than shares of Restricted Stock, Additional Restricted Stock or other shares of Common Stock being registered in such offering), without the consent of
the underwriters managing such offering, for a period of not more than 180 days following the effective date of the registration statement relating to such offering, if all persons holding in excess of 1% of the capital stock of the Company on a
fully diluted basis and all executive officers and directors of the Company shall be similarly restricted. 
   (h)
The Company shall not grant to any third party any registration rights more favorable than or inconsistent with any of those contained herein, so long as any of the registration rights under this Agreement remains in effect. 

  (i) If any provision of this Agreement shall be held to be illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner affect or render illegal, invalid or unenforceable any other provision of this Agreement, and this Agreement shall be carried out as if any such illegal, invalid or
unenforceable provision were not contained herein. 

  

- 14 - 

   (j) This Agreement, together with the other writings referred to herein or
delivered pursuant hereto which form a part hereof, contains the entire agreement among the parties with respect to the subject matter hereof and amends, restates and supersedes all prior and contemporaneous arrangements or understandings, whether
written or oral, with respect thereto, including without limitation (a) that certain Fourth Amended and Restated Registration Rights Agreement, dated as of September 19, 2008, among the Company, the Founders and the Investors named
therein; (b) that certain Third Amended and Restated Registration Rights Agreement, dated as of July 15, 2008, among the Company, the Founders and the Investors named therein; (c) that certain Second Amended and Restated Registration
Rights Agreement, dated as of May 16, 2006, among the Company, the Founders and the Investors named therein, (d) that certain Amended and Restated Registration Rights Agreement, dated as of October 13, 2004, among the Company, the
Founders and the Investors named therein, (e) that certain Registration Rights Agreement dated October 27, 2003 between the Company and Genzyme Corporation, (f) that certain Registration Rights Agreement dated as of September 15,
2000, by and among the Company and the Investors and Founders named therein, as amended by (i) that certain Amendment No.1 to Registration Rights Agreement dated as of December 4, 2000, by and among the Company, Alexandria Real Estate
Equities, L.P. (“ARE”), and the Founders and Investors named therein, (ii) that certain Amendment No. 2 to Registration Rights Agreement dated as of June 10, 2002, by and among the Company, the Board of Regents of the
University of Texas System (the “University”), and the New Purchasers, Founders and Investors named therein, (iii) that certain Amendment No. 3 to Registration Rights Agreement, dated as of October 27, 2003, by and
among the Company, the University and the New Purchasers, Founders, and Investors named therein, and (g) Section 16 of that certain Warrant for the Purchase of Shares of Common Stock granted to ARE, dated October 31, 2000. 

  (k) Notwithstanding anything to the contrary in this Agreement, the Company and Eli Lilly & Company
(“Lilly”) each acknowledge and agree that Lilly shall not have any rights or liabilities under this Agreement unless and until Lilly acquires any Securities pursuant to that certain Securities Purchase Agreement, dated as of
September 19, 2008, by and among the Company and the Purchasers (including Lilly) named therein (the “Purchase Agreement”). The terms “Securities” and “Purchasers”, as used in this Section 14(k), shall
have the meanings ascribed to such terms in the Purchase Agreement. 
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Blank] 

  

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 IN WITNESS WHEREOF, this Agreement is effective as of the date first written above.

  

			
	MACROGENICS, INC.
		
	By:	 	  

	Name:	 	Scott Koenig, M.D., PhD
	Title:	 	President & Chief Executive Officer

 EXHIBIT A 
 Founders 
 The Scott Koenig Family Trust 

Scott Koenig 
 Jeffrey Ravetch 

Leroy Hood 
 Alan Aderem 

Ruedi Aebersold 
 The Institute for Systems
Biology 
 Ethan Ravetch Trust 
 Jared
Ravetch Trust 

 EXHIBIT B 
 Existing Investors 
 Ventures West 8 Limited Partnership 

Rivervest Venture Fund I, L.P. 
 Caisse De Depot
Et Placement du Quebec 
 Alta Biopharma Partners III, L.P. 
 Alta Biopharma Partners III GMBH & Co. Beteiligungs KG 
 Alta Embarcadero Biopharma
Partners III, LLC 
 TPG Ventures, L.P. 

TPG Biotechnology Partners, L.P. 
 Red Abbey
Venture Partners (QP), LP 
 Red Abbey Venture Partners, LP 
 Red Abbey CEO’s Fund, LP 
 MPM Bioventures II, L.P. 

MPM Bioventures II-QP, L.P. 
 MPM Bioventures
GMBH & Co. Parallel-Beteiligungs KG 
 MPM Asset Management Investors 2000 B LLC 

MPM Bioventures IV Strategic Fund LP 
 Interwest
Partners VIII, L.P. 
 Interwest Investors VIII, L.P. 
 Interwest Investors Q-VIII, L.P. 
 Mithra Ventures, L.P. 

Cogene Biotech Ventures, L.P. 
 Orbimed
Associates LLC 
 Caduceus Private Investments, LP Fort Washington Private Equity Opportunities Fund II, L.P. 

The Board of Regents of the University of Texas System 
 Startech Seed Fund II, L.P. 
 Biotechnology Development Fund II, L.P. 

Hunt Ventures 
 Audax Private Equity Fund, L.P.

 Audax Co-Invest, L.P. 
 Audax Trust
Co-Invest, L.P. 
 Audax Special Purpose Co-Invest, L.P. 
 AFF Co-Invest, L.P. 
 Genzyme (Sanofi-Genzyme BioVentures) 

Emerging Tech 

 EXHIBIT C 
 Series D Investors 
 BioMedical Sciences Investment Fund Pte Ltd 

Biogen Idec MA, Inc. 
 Grand Cathay Venture
Capital Co., LTD. 
 Grand Cathay Venture Capital III Co., LTD. 
 Prudence Venture Investment Corp. 
 Dow Chemical Company 

CMEA Ventures Life Sciences 2000, Civil Law Partnership 
 CMEA Ventures Life Sciences 2000, L.P. 
 Cogene Biotech Ventures, L.P. 

Jennifer Fonstad 
 H&Q Healthcare Investors

 H&Q Life Sciences Investors 

Integra Ventures III, L.P. 
 Montgomery RAVEN
Partnership 
 MUFG Venture Capital I, Limited Partnership 
 Pequot Healthcare Venture Fund, L.P. 
 Pequot Offshore Private Equity Partners III, L.P.

 Pequot OHV Fund, L.P. 
 Pequot
Private Equity Fund III, L.P. 
 PHCV RAVEN Series D Grantor Trust 
 Ridgeback Capital Investments L.P. 
 Saints Capital V, L.P. 

2180 Associates Fund VII, L.P. 
 U.S. Venture
Partners VII, L.P. 
 USVP Entrepreneur Partners VII-A, L.P. 
 USVP Entrepreneur Partners VII-B, L.P. 
 Vulcan Capital Venture Capital I LLC 

HCP Life Science Assets TRS, LLC 

Montgomery & Co., LLC 
 George G.
Montgomery 
 Keith W. Marshall 
 Jeremy
Taylor 

 EXHIBIT D 
 New Investors 
 Arcus Ventures, L.P. 

Innovis Investments, L.P. 
 ONC Partners, L.P.

 Eli Lilly and Company 
 Alexandria
Equities, LLC 
 Boehringer Ingelheim GmbH 
 Green Cross Corp.

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