Document:

EX-10.21

 Exhibit 10.21 

June 1, 2016 
 Uma Sinha, Ph.D. 

Dear Uma, 
 Eidos Therapeutics, Inc. (the
“Company”) is pleased to offer you employment on the following terms: 
 1. Position. Your initial title will be Chief Scientific Officer.
Effective as of June 1, 2016, you will report to the Company’s CEO and you shall have such powers and duties as may from time to time be prescribed by the Chairman of the Board of Directors of the Company (the “Board”) or the
President, provided that such duties are consistent with the position of Chief Scientific Officer or other positions that you may hold from time to time. This is initially a part-time position and you will be required to devote 3 days per week to
the business and affairs of the Company. During your employment with the Company, you will not engage in any outside employment, consulting or other business activity (whether full-time or part-time) without the Company’s written consent, which
shall not be unreasonably withheld, other than the for profit and non-profit consulting activities in which you currently engage (which have been previously disclosed to the Company), or any work for BridgeBio
Pharma, LLC (“BridgeBio”) under that certain letter agreement dated June 10, 2016, provided that such consulting activities or future work for a non-profit do not materially interfere with your
performance of duties to the Company under this letter agreement. By signing this letter agreement, you confirm to the Company that you have no contractual commitments or other legal obligations that would prohibit you from performing your duties
for the Company. 
 2. Salary. The Company will pay you a starting salary beginning as of June 1, 2016 at the annual rate of $300,000, payable
in accordance with the Company’s standard payroll schedule and subject to tax-related deductions and withholdings. This salary will be subject to adjustment pursuant to the Company’s employee
compensation policies in effect from time to time. 
 3. Employee Benefits. You will be eligible to participate in or receive benefits under the
Company’s employee benefit plans in effect from time to time (including, without limitation, any group health care plan when established), subject to the terms of such plans. If a group plan is not established or to the extent that you are not
eligible to participate in such plan once established, the Company will reimburse the cost of your COBRA insurance or individual insurance plan until a group plan is set up in which you are eligible. 

4. Stock Award. Subject to the approval of the Board, you will be issued a stock award consisting of 95,480 shares of the Company’s Common Stock
(the “Stock Award”) (this amount is equal to approximately 0.95% of the Company’s fully-diluted equity as of the date of issuance, assuming the purchase of an aggregate of $8,000,000 in the Company’s Series Seed Preferred Stock
by BridgeBio at a purchase price of $1.3248 per share) at a purchase price per share equal to 100% of the fair market value of the Company’s Common Stock on the issuance date, as determined by the Board or the Compensation Committee, which
determination and issuance dates shall occur as promptly as practicable following your acceptance of this offer. The shares issued under the Stock Award will be subject to the terms and conditions applicable to awards granted under the Eidos
Therapeutics, Inc. 2016 Equity Incentive Plan (the “Plan”), as described in the Plan and the applicable stock award agreement, copies of which have been provided to you. The shares issued under the Stock Award will be fully vested upon
issuance; provided, that in the event of any termination of your continuous service relationship with the Company, the Company shall have the option to repurchase the shares issued under the Stock Award at the fair market value of such shares on the
date of repurchase (as determined under the Plan) (the “Repurchase Right”); provided, however, that the Repurchase Right shall lapse as to 25% of the shares after 12 months of your continuous service for the Company, commencing as of
June 1, 2016, and the Repurchase Right shall lapse as to the remaining 75% of the shares in equal monthly installments over the next 36 months of your continuous service for the Company, as described in the applicable stock award agreement.

 5. Employee Confidentiality and Assignment Agreement. Like all Company employees, you will be
required, as a condition of your employment with the Company, to sign the Company’s standard Proprietary Information and Inventions Agreement, a copy of which is attached hereto as Exhibit A. 

6. Employment Relationship. Employment with the Company is for no specific period of time. Your employment with the Company will be “at
will,” meaning that either you or the Company may terminate your employment at any time and for any reason, with or without cause. Any contrary representations that may have been made to you are superseded by this letter agreement. Although
your job duties, title, reporting relationship, compensation and benefits, as well as the Company’s personnel policies and procedures, may change from time to time, the “at will” nature of your employment may only be changed in an
express written agreement signed by you and a duly authorized officer of the Company (other than you). 
 7. Interpretation, Amendment and
Enforcement. This letter agreement and Exhibit A constitute the complete agreement between you and the Company, contain all of the terms of your employment with the Company and supersede any prior agreements, representations or understandings
(whether written, oral or implied) between you and the Company. This letter agreement may not be amended or modified, except by an express written agreement signed by both you and a duly authorized officer of the Company. The terms of this letter
agreement and the resolution of any disputes as to the meaning, effect, performance or validity of this letter agreement or arising out of, related to, or in any way connected with, this letter agreement, your employment with the Company or any
other relationship between you and the Company will be governed by California law, excluding laws relating to conflicts or choice of law. 

We hope that you will accept our offer to join the Company. You may indicate your agreement with these terms and accept this offer by signing
and dating both the enclosed duplicate original of this letter agreement and the enclosed Confidentiality Agreement and returning them to me. This offer, if not accepted, will expire at the close of business on June 30, 2016. As required by
law, your employment with the Company is contingent upon your providing legal proof of your identity and authorization to work in the United States. Should you accept this offer, your start date of employment will be June 1, 2016 or any other
date agreed upon between you and the Company. 
 If you have any questions, please do not hesitate to contact me. 

 

	
	Very truly yours,
	
	 /s/ Neil Kumar

	Neil Kumar
	CEO
	EIDOS THERAPEUTICS, INC.

  

	
	I have read and accept this employment offer:
	
	/s/ Uma Sinha
	Uma Sinha Ph.D.

 Effective as of June 1, 2016 

Attachment 
 Exhibit A: Proprietary Information and
Inventions Agreement 

  
 2 

 

 
 May 24, 2018 
 Uma Sinha,
Ph.D. 
 Re: Amendment to Offer Letter 
 Dear Uma, 

Reference is made to your offer letter dated June 1, 2016 (the “Offer Letter”). Eidos Therapeutics, Inc. (the
“Company”) has agreed to amend the Offer Letter to provide you with certain additional benefits described below. 
 Severance.
In the event your employment is terminated by the Company (or its acquirer or successor) without Cause (as defined in the Eidos Therapeutics, Inc. 2016 Equity Incentive Plan (the “Plan”) or if you resign for Good Reason (as defined
below) within one (1) month before or twelve (12) months after a Change in Control (as defined in the Plan), subject to you signing a general release of claims in favor of the Company that becomes irrevocable within sixty (60) days
following the termination date, you will be entitled to be paid a lump sum payment equal to nine (9) months of your then-current base salary, an amount equal to your target bonus for the year in which your employment was terminated (pro-rated in the case of any partial year during which you were employed by the Company) and nine (9) months of COBRA reimbursement for you and your dependents if you were participating in the Company’s
group health plan immediately prior to the termination date and elect COBRA health continuation (the “Change in Control Severance”). In the event you are terminated by the Company without Cause or if you resign for Good Reason other than
in connection with a Change in Control as described above, subject to you signing a general release of claims in favor of the Company that becomes irrevocable within sixty (60) days following the termination date, you will be entitled to be
paid a lump sum payment equal to six (6) months of your then-current base salary, an amount equal to your target bonus for the year in which your employment was terminated (pro-rated in the case of any partial year during which you were
employed by the Company) and six (6) months of COBRA reimbursement for you and your dependents if you were participating in the Company’s group health plan immediately prior to the termination date and elect COBRA health continuation (the
“Severance”). If the 60-day period following the termination date begins in one calendar year and ends in a second calendar year, the Change in Control Severance or the Severance, as the case may be,
shall be paid in the second calendar year and no later than the last day of such 60-day period. Furthermore, to the extent you become eligible for health benefits under a subsequent employer’s health plan
within six (6) months of your termination date, you agree to return a pro-rated amount of the COBRA reimbursement to the Company (or its acquirer or successor) within sixty (60) days from when you
first become eligible to participate in the subsequent employer’s health plan. For purposes of this agreement, “Good Reason” shall mean that you have complied with the “Good Reason Process” (hereinafter defined) following
the occurrence of any of the following events: (i) a material diminution in your responsibilities, authority or duties, (ii) a diminution of over twenty-five (25%) percent in your salary or bonus potential or (iii) a change of more
than twenty-five (25) miles in the geographic location 

 
at which you provide services to the Company. “Good Reason Process” shall mean that (i) you have reasonably determined in good faith that a “Good Reason” condition has
occurred, (ii) you provide the Company written notice that such an event has occurred within thirty (30) days of the first occurrence of such condition, (iii) you cooperate in good faith with the Company’s efforts, for a period
not less than thirty (30) days following such notice (the “Cure Period”), to remedy the condition, (iv) notwithstanding such efforts, the Good Reason condition continues to exist, and (v) you terminate your employment within
thirty (30) days after the end of the Cure Period. 
 The remainder of your offer letter will remain unchanged. 

If you have any questions, please do not hesitate to contact me. 
  

	
	Very truly yours,
	
	/s/ Neil Kumar
	Neil Kumar
	CEO
	Eidos Therapeutics, Inc.

  

	
	I have read and accept this employment offer:
	
	/s/ Uma Sinha
	Uma Sinha, Ph.D.
	
	Dated: May 24, 2018EX-10.22

 Exhibit 10.22 

 
 

 
 February 20, 2019 

Charles Homcy 
 Sent Via Email 

Re: BridgeBio Services Employment 
 Dear Charles: 

BridgeBio Services, Inc. (the “Company”) is pleased to offer you employment as Senior Advisor, Chair of Pharmaceuticals. With powers, duties,
responsibilities, and accountabilities as set forth below and in the job description for the position, or as may from time to time be prescribed by the Company’s senior executives or the Board of Directors of the Company (the
“Board”), provided that such duties are consistent with your position. In your role, you would also act as a Management Committee Member. 
 The
position is a part-time, exempt position and you will be required to devote 20% of your full working time and efforts to the business and affairs of the Company. During your employment with the Company, you will not engage in any other outside
employment, consulting or other business activity (whether full-time or part-time) without the Company’s written consent, which shall not be unreasonably withheld. By signing this letter agreement, you confirm to the Company that you have no
contractual commitments or other legal obligations that would prohibit you from performing your duties for the Company. 
 The Company will pay you a
starting salary beginning as of your start date at the annual rate of $500,000.00, payable in accordance with the Company’s standard payroll schedule and subject to tax-related deductions and
withholdings. This salary will be subject to adjustment pursuant to the Company’s employee compensation policies in effect from time to time. 
 You
will be eligible to participate in or receive benefits under the Company’s employee benefit plans in effect from time to time (including, without limitation, any group health care plan, Paid Time Off, and 401(k)), subject to the terms of such
plans. 
 It is understood that you are an “at-will” employee. You are not being offered employment for a
definite period of time, and either you or the Company may terminate the employment relationship at any time and for any reason, with or without cause or prior notice and without additional compensation to you. Any contrary representations that may
have been made to you are superseded by this letter agreement. Although your job duties, title, reporting relationship, compensation and benefits, as well as the Company’s personnel policies and procedures, may change from time to time (except
as otherwise provided herein), the “at will” nature of your employment may only be changed in an express written agreement signed by you and a duly authorized officer of the Company (other than you). 

Like all Company employees, you will be required, as a condition of your employment with the Company, to sign the Company’s standard Proprietary
Information and Inventions Agreement (the “Confidentiality Agreement”), a copy of which is attached hereto as Exhibit A. 
 This offer is
contingent upon a background check clearance, reference check, and satisfactory proof of your right to work in the United States. You agree to assist as needed and to complete any documentation at the Company’s request to meet these conditions.

  
 421 Kipling Street, Palo
Alto, CA 94301 

 

 
  

 The Immigration Reform and Control Act requires employers to verify the employment eligibility and identity
of new employees. You will be required to complete a Form 1-9 which will be provided to you before your start date. Please bring the appropriate documents listed on that form with you when you report for work.
We will not be able to employ you if you fail to comply with this requirement. Also, this offer is subject to satisfactory reference checks if necessary. 

This letter agreement and the Confidentiality Agreement constitute the complete agreement between you and the Company, contain all of the terms of your
employment with the Company and supersede any prior agreements, representations or understandings (whether written, oral or implied) between you and the Company. This letter agreement may not be amended or modified, except by an express written
agreement signed by both you and a duly authorized officer of the Company, although your job duties, title, reporting relationship, compensation and benefits may change from time to time. 

We hope that you will accept our offer to join the Company. You may indicate your agreement with these terms and accept this offer by signing and dating both
the enclosed duplicate original of this letter agreement and the enclosed Confidentiality Agreement and returning them to me. This offer, if not accepted, will expire at the close of business on Wednesday, January 23. Should you accept this offer,
your start date of employment will be retroactive to January 1, 2019 or any other date agreed upon between you and the Company. 
  

	
	Sincerely,
	
	 /s/ Neil Kumar

Neil Kumar and the BridgeBio Team

	
	I have read and accept this employment offer.
	
	/s/ Charles Homcy
	Charles Homcy
	
	2/20/19
	Date

  
 421 Kipling Street, Palo
Alto, CA 94301

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