Document:

<PAGE>

                                                                  EXECUTION COPY

                                                                     EXHIBIT 4.4

                        FIRST AMENDMENT TO NOTE AGREEMENT

               THIS FIRST AMENDMENT TO NOTE AGREEMENT (this "Amendment"), dated
as of November 30, 2001, among U.S. CONCRETE, INC., a Delaware corporation (the
"Company"), and the financial institutions listed on the signature pages hereto
as Purchasers (the "Purchasers"), amends the Agreement referred to below. All
capitalized terms used herein and not otherwise defined shall have the meanings
provided such terms in the Agreement referred to below.

                              W I T N E S S E T H :
                              - - - - - - - - - -

               WHEREAS, the Company and the Purchasers are parties to a Note
Agreement, dated as of November 10, 2000 (as amended, modified and/or
supplemented prior to the date hereof, the "Agreement"); and

               WHEREAS, the Company has requested that the Purchasers amend the
Agreement to modify the definitions of Consolidated Net Earnings, EBITDA and Pro
Forma Operating Income as contained in this Amendment and the Purchasers are
willing to amend such term in accordance with the terms of this Amendment;

               NOW, THEREFORE, it is agreed:

               1. The Purchasers and the Company hereby amend the definitions of
"EBITDA", "Consolidated Net Earnings" and "Pro Forma Operating Income" in
Section 11 of the Agreement as follows:

               "Consolidated Net Earnings" of any Person for any period shall
         mean the net income (or loss) of such Person and its Subsidiaries for
         such period, excluding (i) any extraordinary items, (ii) any equity
         interest of such Person in the unremitted earnings of any Person which
         is not a Subsidiary of such Person and (iii) all non-cash gains as
         determined on a consolidated basis in accordance with generally
         accepted accounting principles.

               "EBITDA" shall mean, for any period, the sum of:

               (i)    the Consolidated Net Earnings of the Company for such
         period, plus (to the extent deducted in determining Consolidated Net
         Earnings of the Company for such period) the aggregate amount of
         federal, state and local income and franchise taxes, interest

                                       1
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         expense, depreciation expense and amortization expense and other
         non-cash charges for such period; and

               (ii)   to the extent not included in determining the amount in
         clause (i), above, for such period, Pro Forma Operating Income.

               "Pro Forma Operating Income" shall mean for each Qualified
         Company whose Acquisition by the Company occurs during the four
         consecutive fiscal quarter period preceding the date as of which EBITDA
         is being calculated and with respect to the period beginning four
         fiscal quarters prior to the calculation of EBITDA through the date of
         such Acquisition, the sum of Consolidated Net Earnings of such
         Qualified Company for such period, plus (to the extent deducted in
         determining Consolidated Net Earnings of such Qualified Company for
         such period) the aggregate amount of federal, state and local income
         and franchise taxes, interest expense, depreciation expense and
         amortization expense and other non-cash charges for such period, plus
         or minus, as applicable, Add-Back Adjustments with respect to such
         Qualified Company, in the case of each such item equal to the amount of
         such item as set forth in the pro forma presentation of the results of
         such Acquisition contained in the applicable form filed or to the filed
         by the Company with the Securities and Exchange Commission reporting
         such Acquisition.

               2. In order to induce the Purchasers to enter into this
Amendment, the Company hereby represents and warrants that no Default or Event
of Default exists as of the Effective Date (as defined below) after giving
effect to this Amendment.

               3. In order to induce the Purchasers to enter into this
Amendment, each of the parties listed on the signature page as Guarantors hereby
ratifies and confirms that the Guaranty Agreement of such Guarantor remains in
full force and effect after giving effect to this Amendment.

               4. This Amendment is limited as specified and shall not
constitute a modification, acceptance or waiver of any other provision of the
Agreement.

               5. This Amendment may be executed in any number of counterparts
and by the different parties hereto on separate counterparts, each of which
counterparts when executed and delivered shall be an original, but all of which
shall together constitute one and the same instrument.

               6. THIS AMENDMENT SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE
WITH, AND THE RIGHTS OF THE PARTIES BE GOVERNED BY, THE LAW OF THE STATE OF NEW
YORK (EXCLUDING ANY CONFLICTS OF LAW RULES WHICH WOULD OTHERWISE CAUSE THIS
AMENDMENT TO BE CONSTRUED OR ENFORCED IN ACCORDANCE WITH OR THE RIGHTS OF THE
PARTIES TO BE GOVERNED BY THE LAWS OF ANY OTHER JURISDICTION).

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               7. This Amendment shall become effective on the date (the
"Effective Date") when the Company and the Required Holders shall have signed a
counterpart hereof (whether the same or different counterparts) and shall have
delivered (including by way of facsimile transmission) the same to the Company.

               8. From and after the Effective Date, all references in the
Agreement shall be deemed to be references to the Agreement as amended hereby.

                     [Rest of Page Intentionally Left Blank]

                                       3
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               IN WITNESS WHEREOF, the parties hereto have caused their duly
authorized representatives to execute and deliver this Amendment as of the date
first above written.

                                       "Company"

                                       U.S. CONCRETE, INC.

                                       By: /s/ MICHAEL W. HARLAN
                                           -------------------------------------
                                           Michael W. Harlan
                                           Senior Vice President

                                       "Purchasers"

                                       THE PRUDENTIAL INSURANCE COMPANY OF
                                       AMERICA

                                       By: /s/ CHRIS BRUCE
                                           -------------------------------------
                                           Vice President

                                       METROPOLITAN LIFE INSURANCE COMPANY

                                       By:______________________________________
                                       Title:___________________________________

                                       TEACHERS INSURANCE & ANNUITY ASSOCIATION
                                       OF AMERICA

                                       By: /s/ LOREN S. ARCHIBALD
                                           -------------------------------------
                                           Managing Director

                                       4
<PAGE>

                                       CONNECTICUT GENERAL LIFE INSURANCE
                                       COMPANY

                                       By: CIGNA, Investments, Inc. (authorized
                                           agent)

                                           By:  /s/ DEBRA J. HEIGHT
                                                --------------------------------
                                                Title:   Managing Director

                                       ALLSTATE LIFE INSURANCE COMPANY

                                       By: /s/ PATRICIA WILSON
                                           -------------------------------------

                                       By: /s/ DANIEL C. LEIMBACH
                                           -------------------------------------

                                       ALLSTATE LIFE INSURANCE COMPANY OF NEW
                                       YORK

                                       By: /s/ PATRICIA WILSON
                                           -------------------------------------

                                       By: /s/ DANIEL C. LEIMBACH
                                           -------------------------------------

                                       SOUTHERN FARM BUREAU LIFE INSURANCE
                                       COMPANY

                                       By:______________________________________
                                       Title:___________________________________

                                       5
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                           Acknowledged and Agreed to:

                                  "Guarantors"

AFTM CORPORATION, a Michigan corporation
AMERICAN CONCRETE PRODUCTS, INC., a California corporation
ATLAS-TUCK CONCRETE, INC., an Oklahoma corporation
BEALL INDUSTRIES, INC., a Texas corporation
BEALL MANAGEMENT, INC., a Texas corporation
CENTRAL CONCRETE CORP., a Delaware corporation
CENTRAL CONCRETE SUPPLY CO., INC., a California corporation
CENTRAL PRECAST CONCRETE, INC., a California corporation
CORDEN, INC., a Michigan corporation
CORNILLIE FUEL & SUPPLY, INC., a Michigan corporation
CORNILLIE LEASING, INC., a Michigan corporation
DENCOR, INC., a Michigan corporation
DYNA, INC., a Delaware corporation
E.B. METZEN, INC., a Michigan corporation
EASTERN CONCRETE MATERIALS, INC., a New Jersey corporation
FENDT TRANSIT MIX, INC., a Michigan corporation
HUNTER EQUIPMENT COMPANY, a Michigan corporation
SUPERIOR CONCRETE MATERIALS, INC. (f/k/a) OPPORTUNITY CONCRETE
  CORPORATION, a District of Columbia corporation
READY MIX CONCRETE COMPANY OF KNOXVILLE, a Delaware corporation
SAN DIEGO PRECAST CONCRETE, INC., a Delaware corporation
SIERRA PRECAST, INC., a California corporation
SMITH PRE-CAST, INC., a Delaware corporation
USC GP, INC., a Delaware corporation
USC MIDSOUTH, INC., a Delaware corporation
WYOMING CONCRETE INDUSTRIES, INC., a Delaware corporation

By: /s/ MICHAEL W. HARLAN
    ------------------------------------------------
    Michael W. Harlan
    Vice President

                                       6
<PAGE>

USC MANAGEMENT CO., LP,
a Texas limited partnership

By: USC GP, INC., its General Partner

    By: /s/ MICHAEL W. HARLAN
        ------------------------------------------
        Michael W. Harlan
        Vice President

BEALL CONCRETE ENTERPRISES, LTD.,
a Texas limited partnership

By:  BEALL MANAGEMENT, INC.,
     its General Partner

    By: /s/ MICHAEL W. HARLAN
        ------------------------------------------
        Michael W. Harlan
        Vice President

CARRIER EXCAVATION AND FOUNDATION
COMPANY, a Delaware corporation

CONCRETE XX ACQUISITION, INC., a
Delaware corporation

PREMIX CONCRETE CORP., a Delaware corporation

SUPERIOR REDI-MIX, INC., a Michigan corporation

By: /s/ CHARLES W. SOMMER
    ----------------------------------------------
    Charles W. Sommer
    Vice President

                                       7
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B.W.B., INC. OF MICHIGAN, a Delaware corporation

CENTRAL CONCRETE CORP., a Delaware corporation

OLIVE BRANCH READY MIX, INC., a Delaware corporation

SUPERIOR MATERIALS COMPANY, INC., a Delaware corporation

By: /s/ DONALD WAYNE
    ----------------------------------------------
    Donald Wayne
    Vice President

                                       8<PAGE>

                                                                    Exhibit 10.3

                Amendment and Extension of Employment Agreement
       Between Boston Life Sciences, Inc. and David Hillson, dated 11/7/94
                                 Attached Hereto

Whereas the parties, Boston Life Sciences, Inc. ("BLSI") and David Hillson
("CEO"), desire to amend and extend the employment agreement dated 11/7/94 and
effective 11/14/94 attached hereto, the following modifications and new terms
shall apply:

     (1)  The original agreement shall be extended by approximately 1 year and
          six weeks to end on December 31, 1998 instead of November 14, 1997.

     (2)  The provisions of the original statement contained in Section 5, page
          5 ("Non-Competition") are modified as shown on the attached copy of
          that agreement.

     (3)  The provisions of the original agreement contained in Section 7 (iv),
          page 8, are modified as shown on the attached copy.

     (4)  The annual salary of the CEO, David Hillson, shall be raised to
          $195,000 commencing January 1, 1997. At the discretion and review of
          the Board of Directors, such annual salary may be increased for the
          second year of the contract, January 1, 1998 to December 31, 1998/

     (5)  With the following exception, no further specific or contractually
          based bonus shall be paid by BLSI to the CEO under this extended
          contract. The only exception to the foregoing is the provision
          contained in the original contract for BLSI to pay CEO a bonus in the
          event a joint venture is consummated upon the terms specified in the
          original contract. However, this bonus obligation shall be in effect
          only through the period of the original (unamended) contract and shall
          therefore end on November 15, 1997.

     (6)  The parties agree that upon signing this amended and extended
          employment agreement, David Hillson shall receive a contract renewal
          payment of $50,000.

The parties have agreed to the above-described modifications and amendments as
well as those indicated as marked and initialed on the original agreement
attached hereto.

Other than the provisions contained above, it is agreed that the terms and
conditions of the original agreement shall remain in full force and continue to
be binding upon both parties.

Boston Life Sciences, Inc.
By:

/s/ Ira Lieberman                           /s/ David Hillson
----------------------------------          ---------------------------------
Ira Lieberman                               David Hillson
Chairman, Compensation Committee            Chairman, President, & CEO

<PAGE>

                         RENEWAL OF EMPLOYMENT AGREEMENT

This renewal Agreement dated as of December 28, 1999 by and between Boston Life
Sciences, Inc., a Delaware Corporation having a place of business at 137 Newbury
Street, 8th Floor, Boston, Massachusetts 02116, (the "Corporation"),'and David
Hillson, an individual residing at 14 Moores Hill Road, Oyster Bay, New York
11771 ("CEO").

                                   WITNESSETH:

         WHEREAS, the Corporation desires to employ the CEO as Chairman,
President, Chief Executive Officer and Director and the CEO desires to be
employed by the Corporation as Chairman, President, Chief Executive Officer and
Director, all pursuant to the terms and conditions hereinafter set forth;

         NOW, THEREFORE, in consideration of the foregoing and the mutual
promises and covenants herein contained, it is agreed as follows:

1. EMPLOYMENT; DUTIES

         (a) The Corporation-. engages and employs the CEO, and the CEO hereby
accepts engagement and employment, as Chairman, Chief Executive Officer,
President and Director of the Corporation and all of its current and/or future
divisions and subsidiaries, to direct, supervise and have responsibility for the
daily operations of the Corporation, including, but not limited to: (i)
directing and supervising the business and research and development efforts of
the Corporation; (ii) managing the other executives and personnel of the
Corporation; (iii) evaluating, negotiating, structuring and implementing
business transactions with the Corporation's customers and suppliers; (iv) to
attend meetings of the Board of Directors of the Corporation; and to perform
such other services and duties as the Board of Directors of the Corporation
shall determine.

         (b) The CEO shall perform the major portion of his duties from the
Corporation's executive offices, which are currently located in Boston, MA and
will also perform some of his duties in the New York City area. Relocation of
CEO to Massachusetts shall not be required. However, the CEO also acknowledges
and agrees that the performance by the CEO of his duties hereunder may require
significant domestic and international travel by the CEO.
(c) The CEO shall devote all of his professional time and maximum effort to the
high quality performance and proper discharge of his duties and responsibilities
as Chief Executive Officer and under this Agreement.

2. TERM

The CEO's employment hereunder shall be for a term of two years commencing on
January 1, 2000 and continuing through the second anniversary of such date.

                                      -1-
<PAGE>

3. COMPENSATION

(a) As  compensation for the performance of his duties on behalf of the
Corporation, the CEO shall be compensated as follows:

     (i)  A base salary of $285,000 per annum.

     (ii) The CEO shall receive additional options to purchase 220,000 shares of
          common stock of the Corporation, as determined by the Board of
          Directors/Compensation Committee in its most recent meeting.

    (iii) In addition to the aforementioned compensation, upon the occurrence
          of the milestone events as defined by the Board of
          Directors/Compensation Committee in its most recent meeting, the CEO
          shall have earned and be entitled to receive such appropriate bonus
          compensation.

     (iv) The Board of Directors shall consider through its Compensation
          Committee, the award of further bonuses to the CEO based upon
          successful equity or equity equivalent financings concluded by the
          Company during the period of this Agreement.

The Corporation shall withhold all applicable federal, state and local taxes,
social security and workers' compensation contributions and such other amounts
as may be required by law or agreed upon by the parties with respect to the
compensation payable to the CEO pursuant to Section 3 (a) hereof.

(b)    The Corporation shall reimburse the CEO for all normal, usual and
       necessary expenses incurred by the CEO in furtherance of the business and
       affairs of the Corporation, including reasonable travel (including cost
       of reasonable lodging and transportation between New York and Boston as
       necessary) and entertainment, against receipt by the Corporation of
       appropriate vouchers or other proof of the CEO's expenditures and
       otherwise in accordance with such Expense Reimbursement Policy as may
       from time to time be adopted by the Board of Directors of the
       Corporation.

(c)    The CEO shall be, during the term of this Agreement, entitled to
       vacations of not less than three (3) weeks per annum.

(d)    The Corporation shall make available to the CEO and his dependents, such
       paid medical, long-term disability, life insurance and such other health
       benefits as the Corporation makes available to its other senior officers
       and directors. Upon termination of full-time employment (other than for
       cause), the corporation will continue to provide to the CEO his then
       existing health benefits (coverage) for a reasonable period of time (not
       less than three years) in the absence of such coverage due to the
       subsequent unemployment of the CEO.

                                      -2-
<PAGE>

4. REPRESENTATIONS AND WARRANTIES BY THE CEO AND CORPORATION
   ---------------------------------------------------------

The CEO hereby represents and warrants to the Corporation as follows:

         (a) Neither the execution and delivery of this Agreement nor the
performance by the CEO of his duties and other obligations hereunder violate or
will violate any statute, law, determination or award, or conflict with or
constitute a default under (whether immediately, upon the giving of notice or
lapse of time or both) any prior employment agreement, contract, or other
instrument to which the CEO is a party or by which he is bound.

(b) The CEO has the full right, power and legal capacity to enter and deliver
this Agreement and to perform his duties and other obligations hereunder. This
Agreement constitutes the legal, valid and binding obligation of the CEO
enforceable against him in accordance with its terms. No approvals or consents
of any persons or entities are required for the CEO to execute and deliver this
Agreement or perform his duties and other obligations hereunder.

The Corporation hereby represents and warrants to the CEO as follows:

(a) The Corporation is duly organized, validly existing and in good standing
under the laws of the State of Delaware, with all requisite corporate power and
authority to own its properties and conduct its business in the manner presently
contemplated.

(b) The Corporation has full power and authority to enter into this Agreement
and to incur and perform its obligations hereunder.

(c) The execution, delivery and performance by the Corporation of this Agreement
does not conflict with or result in a breach or violation of or constitute a
default under (whether immediately, upon the giving of notice or lapse of time
or both) the certificate of incorporation or by-laws of the Corporation, or any
agreement or instrument to which the Corporation is a party or by which this
Corporation or any of its properties may be bound or affected.

5. NON-COMPETITION
   ---------------

(a) The CEO understands and recognizes that his services to the Corporation are
special and unique and agrees that, during the term of this Agreement and,
unless such termination is by the CEO pursuant to 7(a)(iii) below, for a period
of two (2) years from the date of termination of his employment hereunder, he
shall not in any manner, directly or indirectly, on behalf of himself or any
person, firm, partnership, joint venture, Corporation or other business entity
("Person"), enter into or engage in any business as specifically described below
that is competitive with the Corporation's current existing business, proposed
business or research activities, either as an individual for his own account, or
as a partner, joint venturer, executive, agent, consultant, salesperson,
officer, director or shareholder of a Person operating or intending to operate
in the areas of research, o development or commercialization of anti-

                                      -3-
<PAGE>

angiogenesis factors, Parkinson's Disease diagnostics or therapeutics, tumor
targeting diagnostics or therapeutics, or MHC-related diagnostics or
therapeutics or any additional area of business in which the Corporation may
become engaged subsequent to the effective date of this agreement, within the
geographic area of the Corporation's business.

(b) During the term of this Agreement and for two (2) years .thereafter, CEO
shall not, directly or indirectly, without the prior written consent of the
Corporation:

     (i)  solicit or induce any employee of the Corporation or any affiliate to
          leave the employ of the Corporation or any affiliate or hire for any
          purpose any employee of the Corporation or any affiliate or any
          employee who has left the employment of the Corporation or any
          affiliate within six months of the termination of said employee's
          employment with the Corporation; or

     (ii) solicit or accept employment or be retained by any party who, at any
          time during the term of this Agreement, was a customer or supplier of
          the Corporation any affiliate where his position will be related to
          the business of the Corporation; or

    (iii) solicit or accept the business of any customer or supplier of the
          Corporation or any affiliate with respect to products similar to those
          supplied by the Corporation, (c) In the event that the CEO breaches
          any provisions of this Section 5 or there is a threatened breach,
          then, in addition to any other rights which the Corporation may have,
          the Corporation shall be entitled, without the posting of a bond or
          other security, to injunctive relief to enforce the
          restrictions-contained herein. In the event that an actual proceeding
          is brought in equity to enforce the provisions of this Section 5, the
          CEO shall not urge as a defense that there is an adequate remedy at
          law nor shall the Corporation be prevented from seeking any other
          remedies, which may be available.

6. CONFIDENTIAL INFORMATION
   ------------------------

(a) The CEO agrees that during the course of his employment or at any time after
termination, he will not disclose or make accessible to any other person, the
Corporation's products, services and technology, both current and under
development, promotion and marketing programs, lists, trade -- secrets and
other, confidential and proprietary business information of the Corporation or
any of its Clients. The CEO agrees: (i) not to use any such information for
himself or others; and (ii) not to take any such material or reproductions
thereof from the Corporation's facilities at any time during his employment by
the Corporation, except as required in the CEO's duties to the Corporation. The
CEO agrees immediately to return all such material and reproductions thereof in
his possession to the Corporation upon request and in any event upon termination
of employment.

(b) Except with prior written authorization by the Corporation, the CEO agrees
not to disclose or publish any of the confidential, technical or business
information or material of the Corporation, its clients or any other party to
whom the Corporation owes an obligation of confidence, at any time during or
after his employment with the Corporation.

                                      -4-
<PAGE>

(c) CEO hereby assigns to the Corporation all right, title and interest he may
have or acquire in all inventions (including patent rights) developed by the CEO
during the term of this Agreement ("Inventions") and agrees that all Inventions
shall be the sole property of the Corporation and its assigns, and the
Corporation and its assigns shall be the sole owner of all patents, copyrights
and other rights in connection therewith. -CEO further agrees to assist the
Corporation in every proper way (but at the Corporation's expense) to obtain and
from time to time enforce patents, copyrights or other rights on said Inventions
in any and ail countries.

7. TERMINATION
   -----------

(a) The CEO's employment hereunder shall begin on January 1, 2000 and shall
continue for the period set forth in Section 2 hereof unless sooner terminated
upon the first to occur of the following events:

     (i)  The death of the CEO;

     (ii) Termination by the Board of Directors of the Corporation for just
          cause. Any of the following actions by the CEO shall constitute just
          cause:

          (A)  Material breach by the CEO of Section 5 or Section 6 of this
               Agreement;

          (B)  Material breach by the CEO of any provision of this Agreement
               other than Section 5 or Section 6 which is not cured by the CEO
               within fifteen (15) days of notice thereof from the Corporation;
               or

          (C)  Any action by the CEO to intentionally harm the Corporation.

    (iii) Termination by the CEO for just cause. Any of the following actions
          or omissions by the Corporation shall constitute just cause:.

          (A)  Material breach by the Corporation of any provision of this
               Agreement which is not cured by the Corporation within fifteen
               (15) days of notice thereof from the CEO; or

          (B)  Any action by the Corporation to intentionally harm the CEO;

     (iv) Termination by the Board of Directors of the Corporation without just
          cause, provided that the Corporation continues to pay the CEO's full
          base salary for the period commencing with initial employment
          hereunder and ending on December 31, 2001; provided however that the
          hiring of a new President shall not be considered a termination under
          this Agreement, so long as the CEO retains his position as Chairman
          and Chief Executive Officer, or voluntarily resigns from his position
          as CEO. In addition to any, payments due to the CEO at the date of
          termination pursuant to this Section 7(a)(iv), the CEO shall be

                                      -5-
<PAGE>

          entitled to receive at the date of termination, any accrued but unpaid
          bonus compensation described in Section 3(a)(iii) hereof relating to
          milestone events occurring prior to the date of termination. In
          addition, in the event that the CEO is terminated pursuant to this
          Section 7(a)(iv), then the vesting of unvested options granted to the
          CEO pursuant to Section 3 (a) (ii), shall accelerate by a period of 12
          months from the date of termination and be immediately exercisable,
          and/or the provisions of the current stock option plan, including all
          of its amendments shall apply.

(b)  Upon termination pursuant to subparagraph (ii) of paragraph (a) above, the
     CEO shall be entitled to receive his base salary accrued but unpaid as of
     the date of termination, and in the case of (i) above, his estate shall
     also receive accrued but unpaid milestone compensation and vested options
     shall continue to be exercisable by the CEO's estate.

(c)  Beginning 120 days prior to the end of this Agreement (December 31, 2001),
     the CEO will be entitled to a 120-day notice period prior to any
     termination of his employment. During this period his base salary 'will
     continue. In the absence of any other specifically conflicting provision in
     a subsequent employment agreement, this provision (c) will continue in
     force beyond December-31, 2001 for as long as the CEO is employed by the
     Corporation whether or not under an employment agreement.

8. NOTICES
   -------

         Any notice or other communication under this Agreement (including that
pursuant to 7-(c) above) shall be in writing and shall be deemed to have been
given: (i) upon delivery when delivered personally against receipt therefore;
(ii) one (1) day after being sent by Federal Express or similar overnight
delivery; or (iii) three (3) days after being mailed via registered or certified
mail, postage prepaid, return receipt requested, to either party at the address
set forth above, or to such other address as such party shall give by notice
hereunder to the other party.

9. SEVERABILITY OF PROVISIONS
   --------------------------

         If any provision of this Agreement shall be declared by a court of
competent jurisdiction to be invalid, illegal or incapable of being enforced in
whole or in part, such provision shall be interpreted so as to remain
enforceable to the maximum extent permissible consistent with applicable law and
the remaining conditions and provisions or portions thereof shall ' nevertheless
remain in full force and effect and enforceable to the extent they are valid,
legal and enforceable, and no provision shall be deemed dependent upon any other
covenant or provision unless so expressed herein.

10. ENTIRE AGREEMENT MODIFICATION
    ------------------------------

         This Agreement contains the entire agreement of the parties relating to
the subject matter hereof, and the parties hereto have made no agreements,
representations or warranties relating to the subject matter of this Agreement,
which are not set forth herein. No modification of this Agreement shall be valid
unless made in writing and signed by the parties hereto.

                                      -6-
<PAGE>

11. BINDING EFFECT
    --------------

         The rights, benefits, duties and obligations under this Agreement shall
inure to, and be binding upon, the Corporation, its successors and assigns, and
upon the CEO and his legal representatives. This Agreement constitutes a
personal service agreement, and the performance of the CEO's obligations
hereunder may not be transferred or assigned by the CEO.

12. NON-WAIVER
    ----------

         The failure of either party to insist upon the strict performance of
any or the terms, conditions and provisions of this Agreement shall not be
construed as a waiver or relinquishment of future compliance therewith, and said
terms, conditions and provisions shall remain in full force and effect. No
waiver of any term or condition of this Agreement on the part of either party
shall be effective for any purpose whatsoever unless such waiver is in writing
and signed by such party.

13. GOVERNING LAW
    --------------

         This Agreement shall- be governed by, and construed and interpreted in
accordance with, the laws of the State of New York without, regard to principles
of conflict of laws.

14. ARBITRATION

         Resolution of all disputes arising in connection with this Agreement
shall be exclusively governed by and settled in accordance with the provisions
of this Section. Consequently, the parties hereby agree to submit all disputes
to arbitration for final and binding resolution. Either party may initiate such
arbitration by delivery of a demand therefore (the "Arbitration Demand") to the
other party. The arbitration shall be conducted in Boston, Massachusetts, by a
sole arbitrator selected by agreement of the parties not later than 10 days o
after delivery of the Arbitration Demand, or, failing such agreement, appointed
pursuant to the Commercial Arbitration Rules of the America Arbitration
Association. The arbitration shall be conducted pursuant to the Federal
Arbitration Act and such procedures as the parties may agree or, in the absence
of or failing such agreement, pursuant to the AAA Rules. The arbitrator shall
complete all hearings not later than 90 days after his or her selection or
appointment, and shall make a final award not later than 30 days thereafter. The
arbitrator shall apportion all costs and expenses of the arbitration, including
the arbitrator's fees and expenses between the prevailing and non-prevailing
party as the arbitrator shall deem fair and reasonable.

15. HEADINGS

         The headings of paragraphs are inserted for convenience and shall not
affect any interpretation of this Agreement.

                                      -7-
<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
day and year first above written.

                                            BOSTON LIFE SCIENCES, INC.

                                            By: /s/ Ira Lieberman
                                                --------------------------------
                                                Ira Lieberman

                                                Chairman, Compensation Committee

                                            Title: /s/ David Hillson
                                                   -----------------------------
                                                   David Hillson
                                                   Chairman, President & CEO

                                      -8-
<PAGE>

Memorandum

To:      Ira Liberman
From:    David Hillson
Date:    January 23, 2001
Re:      Employment Contract-Extension and Special Retirement Provision
--------------------------------------------------------------------------------

I hereby accept the offer to extend my current employment contract for an
additional year beyond December 31, 2001. The contract will therefore terminate
December 31, 2002. All of its provisions will remain in effect. However, both
parties agree and acknowledge that at any time subsequent to December 31, 2001,
if someone other than David Hillson becomes CEO of the Company, the annual
compensation for David Hillson as Chairman over the remainder of the contract
may be reduced to $200,000.

Once again, thank you for your guidance and input on my long-standing request to
have the Board include a retirement provision/package in my amended employment
agreement.

Amendments to Employment Contract/Special Retirement Provisions

     (1)  In recognition of past services rendered to the Company and to provide
          greater incentive for continued service to BLSI, the Company agrees to
          make the following special provisions for retirement income
          specifically, and only, in the case of David Hillson, its CEO and
          Chairman:

               BLSI will contribute the sum of $100,000 to the purchase of any
               annuity selected by David Hillson who will also contribute
               $200,000 of his own funding for the purchase of such annuity. The
               contribution and purchase will be completed by February 28, 2001.
               The Company will also set aside as pay to David Hillson, as a
               special one-time benefit, the additional sum, of $100,000 in
               January 2001, separate and apart from any other compensation that
               may be due to him either at such time or subsequently. This
               payment will serve to reimburse him for $100,000 of the funding
               provided directly by him at the time the annuity was originally
               purchased in February 2001. The annuity will be owned immediately
               and directly by David Hillson who will be solely responsible for
               the payment of all income taxes on the $200,000 funded on his
               behalf by BLSI.

     (2)  As a special benefit (limited for David Hillson) the Company will
          continue to pay for the same level of healthcare insurance coverage
          (but not disability or life insurance) that it now provides to the CEO
          for the two years following resignation or termination.

     (3)  David Hillson will be granted an additional period of four years in
          which to exercise stock options that have vested or will vest as
          already previously provided and awarded.

My signature below will serve to indicate my acceptance of this contract
extension and special retirement amendment/provision. The Company agrees to
grant this contract extension and special retirement provision as reflected in
the signature below.

Above accepted and agreed by

    /s/ David Hillson                       /s/ Ira Lieberman
----------------------------       ---------------------------------------------
David Hillson                      Ira Lieberman, for Boston Life Sciences, Inc.
Chairman, President &              Chairman, Compensation Committee
Chief Executive Officer

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