Document:

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                                                                   Exhibit 10.19

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                          CONSTRUCTION AGENCY AGREEMENT

                          dated as of November 7, 2001
                                      among
                          GENOME STATUTORY TRUST 2001A
                                    as Lessor

                           HUMAN GENOME SCIENCES, INC.
                              as Construction Agent

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                          CONSTRUCTION AGENCY AGREEMENT

        Construction Agency Agreement, dated as of November 7, 2001 (this
"Agreement"), between Genome Statutory Trust 2001A, (the "Lessor"), and Human
Genome Sciences, Inc., a Delaware corporation ("HGSI"), as Construction Agent.

                              W I T N E S S E T H:
                               - - - - - - - - - -

        A.      Lessor and Construction Agent are parties to that certain
Participation Agreement (as hereafter defined) pursuant to which Construction
Agent, as a Lessee, has agreed to lease from Lessor, and Lessor has agreed to
lease to such Lessee, Lessor's interest in the Properties pursuant to the Lease.

        B.      Lessor, such Lessee and Construction Agent are parties to that
certain Participation Agreement of even date herewith (as amended, supplemented
or otherwise modified, "Participation Agreement"), among HGSI, as Lessee and
Construction Agent, Traville LLC, as Ground Lessor, Lessor, Wells Fargo Bank
Northwest, N.A., as Trustee, BancBoston Leasing Investments Inc. and First Union
National Bank, as Investors, EagleFunding Capital Corporation, as Lender, Fleet
Securities, Inc., as Administrator, Fleet National Bank and First Union National
Bank, as Liquidity Providers, Fleet National Bank, as Fleet National Bank
Collateral Agent, First Union National Bank, as First Union Collateral Agent and
Fleet National Bank, as Administrative Agent and Liquidity Agent.

        C.      Subject to the terms and conditions hereof, (i) Lessor desires
to appoint Construction Agent as its sole and exclusive agent for the
construction of the Traville Improvements on the Traville Site in accordance
with the Approved Traville Construction Budget, Approved Traville Construction
Schedule and Approved Traville Plans and Specifications (each as described more
fully in Exhibit A hereto and as each of the foregoing may be modified from time
to time in accordance with this Agreement)(collectively, the "Traville
Construction Materials") pursuant to this Agreement, and (ii) Construction Agent
desires, for the benefit of Lessor, to cause the Traville Improvements to be
constructed in accordance with the Traville Construction Materials and in each
case in accordance with the terms set forth herein and in the Participation
Agreement.

        D.      Subject to the terms and conditions hereof, the satisfaction or
waiver of the conditions set forth in Section 4.3 of the Participation
Agreement, and the delivery of the Manufacturing Facility Supplement (i) Lessor
desires to appoint Construction Agent as its sole and exclusive agent for the
construction of the Manufacturing Facility Improvements on the Manufacturing
Facility Site in accordance with the Approved Manufacturing Construction Budget,
Approved Manufacturing Construction Schedule and Approved Manufacturing Plans
and Specifications (each as will be described more fully in Exhibit A to the
Manufacturing Facility Supplement and as each of the foregoing may be modified
from time to time in accordance with this Agreement)(collectively, the
"Manufacturing Construction Materials") and pursuant to this Agreement, and (ii)
Construction Agent desires, for the benefit of Lessor, to cause the
Manufacturing Facility Improvements to be constructed in accordance with the
Manufacturing Construction Materials and in each case in accordance with the
terms set forth herein and in the Lease.

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        NOW, THEREFORE, in consideration of the foregoing, and for other good
and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, and intending to be legally bound hereby, the parties hereto
covenant and agree as follows:

                                    ARTICLE I
                                   DEFINITIONS

        1.1     Definitions; Interpretation; Amendment and Restatement.
Capitalized terms used but not otherwise defined in this Agreement shall have
the meanings set forth in Appendix A to the Participation Agreement, and the
rules of interpretation set forth therein shall apply to this Agreement.

                                   ARTICLE II
                        APPOINTMENT OF CONSTRUCTION AGENT

        2.1     Appointment and Acceptance.

        Pursuant to and subject to the terms and conditions set forth herein and
in the Participation Agreement and the other Operative Documents, Lessor hereby
irrevocably designates and appoints Construction Agent as its exclusive agent
for (i) the purchase of the Manufacturing Facility Site, (ii) the construction
of the Traville Improvements on the Traville Site in accordance with the
Approved Traville Plans and Specifications, and (iii) subject to the
satisfaction or waiver of the conditions set forth in Section 4.3 of the
Participation Agreement and the delivery of the Manufacturing Facility
Supplement, the construction of the Manufacturing Improvements in accordance
with the Approved Manufacturing Plans and Specifications, and Construction Agent
by entering into this Agreement accepts such designation and appointment.

        2.2     Term. This Agreement shall commence on the Documentation Date
and shall terminate with respect to a Property upon the first to occur of:

                (a)     Substantial Completion of such Property and the
        performance of all other material obligations of Construction Agent
        hereunder with respect thereto; and

                (b)     payment by Lessee or Lessor's receipt through other
        provisions of the Operative Documents of the aggregate Lease Balance, or
        the applicable Lease Balance for such Property, and all other amounts
        owing under the Operative Documents (including Article V of the Lease,
        incorporated herein by reference), and termination of the Commitments in
        accordance with the Participation Agreement; and

                (c)     termination of this Agreement by Lessor pursuant to
        Article V.

        2.3     Supplement to this Agreement. On the Manufacturing Facility Site
Purchase Date, Lessor and Construction Agent shall execute and deliver a
supplement to this Agreement in the form set forth on Exhibit B hereto (the
"Manufacturing Facility Supplement"), appropriately completed, pursuant to which
Lessor and Construction Agent shall, among other things, each acknowledge and
agree that the construction and development of the Manufacturing Facility on the
Manufacturing Facility Site will be governed by the terms of this Agreement.

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

Following the execution and delivery of the Manufacturing Facility Supplement as
provided above and the satisfaction or waiver of all of the conditions set forth
in Section 4.3 of the Participation Agreement, such Manufacturing Facility
Supplement, and Exhibit A to the Manufacturing Facility Supplement attached
thereto, shall constitute a part of this Agreement.

        2.4     Construction Materials; Construction Documents.

                (a)     Traville Facility

                        (i)     Construction Agent shall develop, define, refine
                and detail proposed budgets, construction schedules and Traville
                Plans and Specifications for the Traville Facility. Construction
                Agent shall cause each such proposal to provide for compliance
                and conformance with generally accepted construction practices,
                Applicable Law, Insurance Requirements, Environmental
                Requirements and Section 2.6(a) and shall cause each such
                proposal to have a reasonable likelihood that it can be
                completed as intended on time and within budget. In addition,
                the budget for the Traville Facility shall not exceed Two
                Hundred and Twenty-Five Million Dollars ($225,000,000), except
                as otherwise provided in clause (ii) below. Construction Agent
                shall cause such proposal to be provided to the Construction
                Consultant for review and approval. Upon the approval of any
                such proposal by the Construction Consultant of such proposed
                construction budget, construction schedule or plans and
                specifications for the Traville Facility, such proposed
                construction budget, construction schedule or plans and
                specifications shall become, as applicable, the approved
                construction budget (as amended or modified from time to time in
                accordance with the Terms of this Agreement, the "Approved
                Traville Construction Budget"), the approved construction
                schedule (as amended or modified from time to time in accordance
                with the Terms of this Agreement, the "Approved Traville
                Construction Schedule") and the approved plans and
                specifications (as amended or modified from time to time in
                accordance with the terms of this Agreement, the "Approved
                Traville Plans and Specifications") for the Traville Facility.
                Failure of the Construction Consultant to respond within sixty
                (60) days of receipt in writing of any such proposal will be
                deemed rejection thereof, however, if the Construction
                Consultant requests additional information or clarifications,
                such sixty (60) day period will commence from the date when all
                such requests have been satisfied. If the Construction
                Consultant shall reject or not expressly approve any such
                proposal, then Construction Agent shall consult with the
                Construction Consultant, revise such proposal and resubmit it,
                repeating such process until all Traville Construction Materials
                are approved or deemed to be approved.

                        (ii)    During the Construction Period, Construction
                Agent may enter into any changes, supplements, amendments or
                revisions ("change orders") to the Traville Construction
                Materials so long as the change order could not reasonably have
                any adverse effect on the as-built value, utility, residual
                value at the end of the Lease Term or useful life of the
                Traville Facility or extend Substantial Completion of the
                Property beyond the Outside Completion Date (such a change order
                that results in an adverse affect described above with respect
                to either

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                Property, a "Material Change Order"), and the costs attributable
                to such change order, together with the costs of all other
                change orders in respect of the Traville Facility, do not result
                in a net increase in the Approved Traville Construction Budget
                unless and only to the extent that the Approved Manufacturing
                Construction Budget has been decreased by a like amount.

                (b)     Manufacturing Facility

                        (i)     Construction Agent shall develop, define, refine
                and detail proposed budgets, construction schedules and
                Manufacturing Plans and Specifications for the Manufacturing
                Facility. Construction Agent shall cause each such proposal to
                provide for compliance and conformance with generally accepted
                construction practices, Applicable Law, Insurance Requirements,
                Environmental Requirements and Section 2.6(a) and shall cause
                each such proposal to have a reasonable likelihood that it can
                be completed as intended on time and within budget. In addition,
                the budget for the Manufacturing Facility shall not exceed Two
                Hundred and Twenty-Five Million Dollars ($225,000,000), except
                as otherwise provided in clause (ii) below. Construction Agent
                shall cause such proposal to be provided to the Construction
                Consultant for review and approval. Upon the approval of any
                such proposal by the Construction Consultant of such proposed
                construction budget, construction schedule or plans and
                specifications for the Manufacturing Facility, such proposed
                construction budget, (as amended or modified from time to time
                in accordance with the terms of this Agreement, the "Approved
                Manufacturing Construction Budget"), the approved construction
                schedule (as amended or modified from time to time in accordance
                with the Terms of this Agreement, the "Approved Manufacturing
                Construction Schedule") and the approved plans and
                specifications (as amended or modified from time to time in
                accordance with the Terms of this Agreement, the "Approved
                Manufacturing Plans and Specifications") for the Manufacturing
                Facility. Failure of the Construction Consultant to respond
                within sixty (60) days of receipt in writing of any such
                proposal will be deemed rejection thereof, however, if the
                Construction Consultant requests additional information or
                clarifications, such sixty (60) day period will commence from
                the date when all such requests have been satisfied. If the
                Construction Consultant shall reject or not expressly approve
                any such proposal, then Construction Agent shall consult with
                the Construction Consultant, revise such proposal and resubmit
                it, repeating such process until all Manufacturing Construction
                Materials are approved or deemed to be approved.

                        (ii)    During the Construction Period, Construction
                Agent may enter into change orders to the Manufacturing
                Construction Materials so long as the costs attributable to such
                change order, together with the costs of all other change orders
                in respect of the Manufacturing Facility, do not result in a net
                increase in the Approved Manufacturing Budget unless and only to
                the extent that the Approved Traville Construction Budget has
                been decreased by a like amount; provided that Material Change
                Orders must comply with clause (iii) below.

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                        (iii)   Prior to making any Material Change Order with
                respect to either Property, Construction Agent shall submit a
                proposal outlining any such proposed change order to the
                Construction Consultant for approval. The approval process for
                Material Change Orders shall allow the Construction Consultant
                twenty (20) days to review any submission and to accept or
                reject such submission (or request additional information in
                respect thereof) with a failure to respond after twenty (20)
                days being deemed acceptance thereof.

                (c)     Subject to each of the terms and conditions in this
        Agreement, Construction Agent may execute any of its duties under this
        Agreement by or through agents, developers, consultants, advisors,
        contractors, employees or attorneys-in-fact (other than the Construction
        Consultant), and Construction Agent with respect to each Property shall
        enter into such agreements with architects and contractors as
        Construction Agent deems necessary or desirable for the completion of
        the Construction pursuant hereto (as such documents may be amended,
        supplemented or otherwise modified except as prohibited hereby, the
        "Construction Documents").

                (d)     Certifications. Any amendment to either the Traville
        Construction Materials or the Manufacturing Construction Materials for
        which Construction Agent does not seek the approval of Lessor shall be
        deemed a certification by Construction Agent that such amendment
        complies with the foregoing requirement.

        2.5     Assignment Under Construction. Construction Agent hereby
collaterally assigns all Material Construction Documents and all the proceeds
(including liquidated damages, insurance proceeds and warranty payments), if
any, payable to Construction Agent or its affiliates under the Construction
Documents to Lessor to secure Construction Agent's obligation under this
Agreement and the Operative Documents. Construction Agent hereby agrees to file
applicable UCC-1 financing statements in respect of the foregoing.

        2.6     Scope of Authority.

                (a)     Subject to the terms, conditions, restrictions and
        limitations set forth in the Operative Documents, Lessor hereby
        expressly authorizes Construction Agent (or any agent, consultant,
        advisor, developer, employee, attorney-in-fact or contractor of
        Construction Agent to which Construction Agent has made a delegation of
        authority pursuant to the terms of this Agreement), and Construction
        Agent unconditionally agrees, for the benefit of Lessor, to take all
        action necessary or (as determined by Construction Agent) desirable for
        the performance and satisfaction of all of Construction Agent's
        obligations hereunder with respect to the Properties, including:

                        (i)     the identification and the acquisition, in the
                name of Lessor (by purchasing or ground leasing, as applicable)
                of each Site in accordance with the terms and conditions of the
                Participation Agreement;

                        (ii)    performing or causing the performance of all
                design and supervisory functions and all engineering work
                related to the Construction and the retention and supervision of
                the General Contractor;

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                        (iii)   negotiating and entering into, or causing the
                negotiation and execution and delivery of, all contracts or
                arrangements to procure the labor, materials, supplies and
                equipment necessary or (as determined by Construction Agent)
                desirable to construct the Improvements;

                        (iv)    obtaining or causing to be obtained all
                necessary permits, licenses, consents, approvals and other
                authorizations, including those required under Applicable Laws
                (including Environmental Laws), from all Governmental
                Authorities in connection with the acquisition of the Sites and
                the Construction of the Improvements thereon;

                        (v)     maintaining or causing to be maintained all
                books and records with respect to the Construction and the
                operation and management of the Properties;

                        (vi)    performing or causing the performance of any
                other acts necessary or desirable (as reasonably determined by
                Construction Agent) in connection with the construction and
                development of the Improvements in accordance in all material
                respects with the Traville Construction Materials or the
                Manufacturing Construction Materials, as applicable, any
                Applicable Laws and all Insurance Requirements; provided,
                however, that the foregoing shall not limit Construction Agent's
                right to engage in Permitted Contests;

                        (vii)   paying when due or causing to be paid when due
                (subject to reimbursement as provided for under this Agreement)
                pursuant to and subject to the Approved Traville Construction
                Budget or Approved Manufacturing Construction Budget, as
                applicable, or the Participation Agreement, all Property Costs
                (including costs associated with Construction Agent's actions as
                provided in Section 2.6(a)(ix) below, pursuant to and subject to
                the Approved Traville Construction Budget or Approved
                Manufacturing Construction Budget, as applicable) provided,
                however, that the foregoing shall not limit Construction Agent's
                right to engage in Permitted Contests. Construction Agent
                acknowledges that any liability resulting to Administrative
                Agent, any Participant or any other Indemnitee as a result of or
                arising from any such negotiation, Permitted Contest, or act or
                omission of Construction Agent or its designees with respect to
                such Permitted Contest will be a Claim subject to
                indemnification under Article IX of the Participation Agreement;

                        (viii)  enforcing or causing the enforcement in all
                material respects of performance by each party to each
                Construction Document of its respective obligations, warranties
                and other design, construction and other obligations with
                respect to the design, engineering, construction and completion
                of the Improvements on the applicable Site or pursuing remedies
                with respect to the breach of those obligations, in each case,
                as deemed appropriate by Construction Agent in its discretion;
                and

                        (ix)    using the proceeds of any insurance maintained
                with respect to the Improvements to complete construction of or
                rebuild any portion of such

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                Improvements with respect to a Casualty or Condemnation and to
                fund all Construction Period Accrued Interest accruing during
                such Construction or rebuild, provided that the foregoing shall
                not affect Construction Agent's right to purchase the Properties
                in accordance with Article V of the Lease which shall be
                applicable during the Construction Period and is hereby
                incorporated herein by reference, mutatis mutandi.

                (b)     Neither Construction Agent nor any of its Affiliates or
        agents shall enter into any contract which would impose any liability or
        obligation on Lessor (other than (i) nonrecourse obligations arising out
        of the imposition of certain Permitted Liens identified on Schedules
        2.6(b)(i) and 2.6(b)(ii) hereto and (ii) Lessor's obligation to
        Construction Agent to provide Advances in accordance with and subject to
        the terms and conditions of the Operative Documents).

                (c)     Subject to the terms and conditions of this Agreement
        and the other Operative Documents, Construction Agent shall have sole
        management and control over the construction means, methods, sequences
        and procedures and the hiring, termination and contracting for and
        supervision of and payment for the labor, personnel and services with
        respect to the Construction; provided, however, that this subsection (c)
        shall not give rise to any rights in any Person other than Lessor, the
        Participants and the other Indemnitees.

                (d)     All fees and expenses of Lessee and Construction Agent
        under any Operative Document which are included in and which may be paid
        in accordance with the Approved Traville Construction Budget or the
        Approved Manufacturing Construction Budget, as applicable, shall be paid
        or reimbursed through Advances.

        2.7     Covenants of Construction Agent. Construction Agent shall with
respect to the Land:

                (a)     following the commencement of Construction, cause the
        Construction to proceed diligently and without material interruption
        (subject to Force Majeure Events) in accordance in all material respects
        with the applicable Construction Materials and Insurance Requirements
        and all Applicable Laws;

                (b)     take or cause to be taken commercially reasonable and
        practical steps to minimize liabilities of Lessor or any Agent or
        Participant, delays, increased costs and the disruption of the
        construction process arising from Force Majeure Events, Casualties and
        Condemnations;

                (c)     subject to Section 3.2(b), cause Substantial Completion
        for a Property to occur on or prior to the applicable Outside Completion
        Date for such Property;

                (d)     cause all Liens (including Liens or claims for materials
        supplied or labor or services performed in connection with the
        construction of the Improvements), other than Permitted Liens, to be
        removed or discharged; provided, however, that the foregoing shall not
        limit Construction Agent's right to engage in Permitted Contests;

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                (e)     at all times during Construction, cause title to all
        Improvements on or within the Land (including any personal property
        which Construction Agent acquires with Advances whether or not such
        personal property so acquired has become a permanent part of such
        Improvements) to be and remain vested in Lessor free of all Liens, other
        than Permitted Liens and Lessor Liens, and cause to be on file
        (including financing statements and fixture filings) with the applicable
        filing office all necessary documents under Article 9 of the UCC to
        perfect Lessor's and Administrative Agent's interest in such personalty
        free of all Liens other than Permitted Liens and Lessor Liens unless and
        only for such period of time as Construction Agent is prevented from
        doing the same as the result of the failure of Lessor to sign and return
        any reasonable documentation prepared by Construction Agent in
        performance of this Section;

                (f)     with respect to each Property, at all times prior to the
        Lease Commencement Date for such Property, maintain, for the benefit of
        Lessor, the insurance described in Schedule 2.7(f) with respect to such
        Property. In addition, Construction Agent shall from time to time, but
        in intervals of not less than twelve (12) months nor more than fifteen
        (15) months, (i) undertake all actions and due diligence as reasonably
        necessary to determine whether the insurance coverage required to be
        maintained hereunder is in compliance with the requirements thereunder,
        including any increases in coverage required as a result of any change
        in any Applicable Laws, and (ii) if Construction Agent determines that
        such insurance coverage does not meet such requirements, promptly take
        all actions and steps necessary to cause such coverage to comply with
        such requirements and shall notify Lessor and Administrative Agent of
        the steps being taken by Construction Agent or on their behalf; and

                (g)     Construction Agent shall not incur nor allow the
        incurrence of any Property Costs, individually or in the aggregate, (A)
        in excess of the sum of the Aggregate Available Commitments and Other
        Available Amounts as of the date of determination thereof or (B) that
        would or could reasonably be expected to cause the applicable
        Construction Budget not to be In Balance.

        2.8     Title to the Improvements. Title to the Improvements (including,
all materials or equipment incorporated therein or paid for out of Advances)
shall automatically, without further act of Construction Agent, vest in Lessor.

                                  ARTICLE III
                                THE IMPROVEMENTS

        3.1     Amendments; Modifications. [Intentionally Omitted.]

        3.2     Casualty, Condemnation, Liquidated Damages and Force Majeure
Events.

                (a)     Subject to Section 3.2(b), if at any time prior to
        Substantial Completion of a Property there occurs a Casualty,
        Condemnation or Force Majeure Event or liquidated damages are paid under
        the Construction Documents, then, in accordance with the procedures for
        making Advances in the Operative Documents, Lessor shall make (x) so
        long as no Construction Agency Event of Default or Bankruptcy Default
        shall have

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        occurred and be continuing, insurance proceeds and/or condemnation
        awards and/or liquidated damages with respect thereto available for
        Improvement Costs and (y) Advances for Improvement Costs and
        Construction Agent shall (i) promptly and diligently complete the
        Construction in accordance with the Traville Construction Materials and
        the Manufacturing Construction Materials, as applicable, and with the
        terms hereof and (ii) cause Substantial Completion for each Property to
        occur on or prior to the applicable Outside Completion Date for such
        Property.

                (b)     If Construction Agent reasonably determines that a Force
        Majeure Event will cause Substantial Completion for either Property to
        occur later than the applicable Outside Completion Date for such
        Property, Construction Agent may request that the applicable Outside
        Completion Date for such Property be extended by Lessor for the period
        (not to exceed one hundred and twenty (120) days following the original
        Outside Completion Date for such Property) reasonably necessary to
        achieve Substantial Completion for such Property in light of such Force
        Majeure Event. Any such request shall be in writing delivered to Lessor
        and Administrative Agent and shall contain a certification by
        Construction Agent (1) describing the facts and circumstances giving
        rise to such Force Majeure Event, the expected duration of such Force
        Majeure Event and the date Construction Agent reasonably believes
        Substantial Completion for the applicable Property will be achieved, (2)
        that the remaining Aggregate Available Commitments, together with
        insurance proceeds paid and Other Available Amounts, if any, with
        respect to such Force Majeure Event which Construction Agent agrees to
        pay with respect to amounts accruing during the period of such
        extension, are adequate to achieve Substantial Completion for such
        Property within such extension period in accordance with the Traville
        Construction Materials or the Manufacturing Construction Materials, as
        applicable (excluding all Construction Period Accrued Interest,
        Construction Period Accrued Yield and Construction Period Fees
        applicable to such Property accruing during such extension period) and
        (3) that the occurrence of such Force Majeure Event and the Construction
        to occur following such date will not materially affect the appraised
        value set forth in the applicable As-Built Appraisal delivered with
        respect to such Site pursuant to Section 4.1(s) or 4.3(q), as
        applicable, of the Participation Agreement. Construction Agent shall
        also supply to Lessor and Administrative Agent such other information as
        each such Person may reasonably request. The consent of Lessor under
        this Section shall not be withheld or delayed if the determination is
        made that the request meets the requirements set forth herein in all
        material respects.

        Notwithstanding the foregoing paragraph, the applicable Outside
Completion Date for such Property shall be automatically extended for the period
(not to exceed a total of sixty (60) days following the original Outside
Completion Date for such Property) necessary to achieve Substantial Completion
for such Property in light of such Force Majeure Event, provided, that (A) the
length of the extension required in light of such Force Majeure Event is certain
(either because the Force Majeure Event has ended or because Construction Agent
has entered into a replacement contract with a definite term (unimpeded by such
Force Majeure Event) to complete the work originally interrupted by the Force
Majeure Event), and (B) Construction Agent delivers to the Administrative Agent
certification (without assumptions or, except as set forth therein,
qualifications) as to and describing the items supporting each of the matters
set forth in

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

clauses (1), (2) and (3) of the foregoing paragraph and stating the length of
the required extension as provided in clause (A) of this paragraph.

                                   ARTICLE IV
                                PAYMENT OF FUNDS

        4.1     Funding of Improvement Costs.

                (a)     During the course of the Construction of Improvements,
        Construction Agent shall request that Lessor advance funds for the
        payment or reimbursement of Improvement Costs and Lessor shall comply
        with such request to the extent provided for under the Participation
        Agreement. Construction Agent and Lessor acknowledge and agree that
        Construction Agent's right to request funds and Lessor's obligation to
        advance funds for the payment of Improvement Costs are subject in all
        respects to the terms of this Agreement, the Participation Agreement and
        each of the other Operative Documents.

                (b)     The proceeds of any funds made available to Lessor under
        the Operative Documents to pay Improvement Costs shall be made available
        to Construction Agent in accordance with the Advance Request relating
        thereto.

                (c)     Construction Agent may disburse proceeds from an Advance
        Request only for payment or its reimbursement of Improvement Costs as
        set forth on the Advance Request or otherwise permitted by the Operative
        Documents.

                (d)     Construction Agent and Lessor, each acknowledge that the
        Administrative Agent or the Investors may direct Lessor to borrow funds
        from the Lenders and the Investors for the payment or reimbursement of
        Transaction Costs and other expenditures, all in accordance with the
        Participation Agreement and the other Operative Documents.

                                   ARTICLE V
                      CONSTRUCTION AGENCY EVENTS OF DEFAULT

        5.1     Construction Agency Events of Default.

                5.1.1 Defined. Any one or more of the following events shall be
        a "Construction Agency Event of Default":

                        (a)     Construction Agent applies any Advance for the
                purposes other than as set forth in the related Advance Request
                or Construction Agent otherwise applies any funds paid by Lessor
                to Construction Agent for purposes not permitted hereby or by
                any other Operative Document, or there shall exist any other
                misapplication of funds relating to any Property, including, but
                not limited to fraud, illegal acts or willful misconduct by
                Construction Agent or its Affiliates or any Construction Agency
                Person or any other Person under the direct or indirect
                supervision of Construction Agent related to or in respect of
                the transactions contemplated herein or the Operative Documents
                or with respect to any Property or Site;

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                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                        (b)     Construction Agent shall fail to comply with
                Section 2.7(c).

                        (c)     (i) either the Approved Traville Construction
                Budget or the Approved Manufacturing Construction Budget shall
                not be In Balance and such failure to be In Balance shall
                continue after the expiration of the thirty (30) day period
                discussed in Section 5.6(b), or (ii) Construction Agent shall
                fail to timely make a Balancing Deposit required under Section
                5.6(c);

                        (d)     an Insolvency Event with respect to Construction
                Agent shall have occurred and be continuing;

                        (e)     HGSI shall default in the due performance and
                observance of any of its obligations under Section 6.1(v), (w),
                (x), (y) or (aa) of the Participation Agreement or Section
                2.5(a)(i) or (ii) of either Liquid Collateral Agreement;

                        (f)     any representation, warranty or statement made
                or restated by Construction Agent or Lessee in this Construction
                Agency Agreement or in any other Operative Document, or in any
                statement or certificate delivered or required to be delivered
                pursuant hereto or thereto, shall prove to be untrue in any
                material respect on the date as of which made or restated, and
                (i) the circumstances rendering such representation or warranty
                or statement incorrect shall not be remediable or, (ii) if such
                representation or warranty or statement is remediable and
                Construction Agent or Lessee is proceeding diligently so to
                remedy, shall continue unremedied for thirty (30) days after the
                earlier of: (x) the date on which written notice is delivered by
                Lessor or Administrative Agent to Construction Agent or Lessee
                specifying such circumstances and demanding that they be
                remedied and (y) the date on which any Authorized Officer of
                Construction Agent or Lessee has actual knowledge of such
                incorrectness; provided, however, that if such default is
                capable of cure but cannot be cured by payment of money or
                cannot be cured by diligent efforts within such thirty (30) day
                period but such diligent efforts shall be properly commenced
                within the cure period and Construction Agent or Lessee is
                diligently pursuing, and shall continue to pursue diligently,
                remedy of such failure, the cure period shall be extended for an
                additional period of time as may be necessary to cure, not to
                exceed an additional one hundred and twenty (120) days and not
                to extend beyond the later Outside Completion Date;

                        (g)     except as otherwise permitted under the
                Operative Documents, any Lien granted pursuant to any Operative
                Document affecting any portion of the Properties shall, in whole
                or in material part, cease to be a perfected first priority
                security interest (other than Permitted Liens and Lessor Liens)
                with respect to any Site for which such Lien is required under
                the Operative Documents, other than with respect to an
                immaterial portion of any such Site, unless such cessation shall
                be the result of the failure of Lessor to sign and return any
                reasonable documentation prepared by Construction Agent in
                performance of Section 2.7(e) or willful misconduct or gross
                negligence of the Administrative Agent or Lessor, provided,
                however, that with respect to any Lien which fails to be so
                effective or

                                       11
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                perfected, Construction Agent shall have thirty (30) days from
                the earlier of Construction Agent's knowledge of such condition
                and receipt of notice thereof from Lessor or Administrative
                Agent to cure such failure;

                        (h)     Construction Agent or Lessee shall default in
                the due performance or observance by it of any term, covenant,
                condition or agreement on its part to be performed or observed
                under any Operative Document to which it is a party (not
                otherwise specified in this Section 18.1) and such default shall
                have continued unremedied for a period of at least thirty (30)
                days after receipt of notice by Construction Agent or Lessee
                from either Lessor or Administrative Agent; provided, however,
                that if such default is capable of cure but cannot be cured by
                payment of money or cannot be cured by diligent efforts within
                such thirty (30) day period but such diligent efforts shall be
                properly commenced within the cure period and Construction Agent
                or Lessee is diligently pursuing, and shall continue to pursue
                diligently, remedy of such failure, the cure period shall be
                extended for an additional period of time as may be necessary to
                cure, not to exceed an additional one hundred and twenty (120)
                days and not to extend beyond the later Outside Completion Date;

                        (i)     an event described in Section 7.3 of the
                Participation Agreement shall have occurred;

                        (j)     the Ground Lease shall terminate by reason of
                default by Ground Lessor in its obligations thereunder;

                        (k)     Construction Agent shall fail to maintain
                insurance required by Section 2.7(f); Construction Agent or
                shall fail to deliver the certification required by Section
                6.1(b)(i) of the Participation Agreement and such failure shall
                continue for ten (10) days after notice to Construction Agent;

                        (l)     the Facility Maturity Date (as defined in the
                Liquidity Agreement), as the same may be modified or extended
                from time to time, with respect to any one or more Liquidity
                Providers shall have occurred;

                        (m)     one or more judgments or orders for the payment
                of money in the aggregate amount in excess of $10,000,000 shall
                be rendered against HGSI or any of its Affiliates and such
                judgment or order shall continue unsatisfied or unstayed for a
                period of sixty (60) days;

                        (n)     An "event of default" shall occur in the payment
                when due (subject to any applicable grace period), whether by
                acceleration or otherwise, of any Indebtedness of HGSI or any of
                its Subsidiaries having a principal amount, individually or in
                the aggregate, in excess of $10,000,000, or a default shall
                occur in the performance or observance of any obligation or
                condition with respect to such Indebtedness;

                                       12
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                        (o)     Lessor's rights pursuant to either Liquid
                Collateral Agreement to require Lessee to pledge additional
                Permitted Investments shall for any reason cease to be a legal,
                valid and binding agreement with Lessee; or

                        (p)     the Lien of either Liquid Collateral Agreement
                with respect to the Liquid Collateral shall cease to constitute
                a first priority perfected security interest (except as a result
                of a voluntary release by Administrative Agent of any Liquid
                Collateral).

                5.1.2 Consequences. Upon the occurrence of a Construction Agency
        Event of Default, Lessor may, in addition to the other rights and
        remedies provided for in this Article V or under the Deed of Trust,
        immediately terminate this Agreement, by giving Construction Agent
        written notice of such termination, and upon the giving of such notice,
        this Agreement shall terminate and all rights of Construction Agent and
        all obligations of Lessor under this Agreement shall cease; provided,
        however, that this Agreement shall terminate immediately without notice
        upon the occurrence of an Insolvency Event described in Section 5.1.1(d)
        or upon the occurrence of the events described in Section 5.1.1(i),
        whether or not another Construction Agency Event of Default described in
        one or more other clauses of Section 5.1.1 shall have been or thereafter
        is declared. Upon any such termination, all rights of Construction Agent
        and all obligations of Lessor (after the date of termination and payment
        of the amounts referred to below in this Section 5.1.2), shall cease
        and:

                (i)     Lessor may require Construction Agent to (or shall
        require Construction Agent to, if a Construction Agency Event of Default
        described in Section 5.1.1(d) or 5.1.1(i) has occurred) (subject to
        Section 5.4 below) immediately pay to Administrative Agent, on behalf of
        Lessor, as and for liquidated damages, an amount equal to:

                        (a)     if a Full Recourse Event of Default has
                occurred, (A) the Lease Balance in the event that, as of the
                date of the termination of this Agreement, the Lease
                Commencement Date shall have not yet occurred with respect to
                either Property, (B) the Traville Lease Balance in the event
                that, as of the date of the termination of this Agreement, the
                Lease Commencement Date shall have already occurred with respect
                to the Manufacturing Facility but shall have not yet occurred
                with respect to the Traville Facility, or (C) the Manufacturing
                Lease Balance in the event that, as of the date of the
                termination of this Agreement, the Lease Commencement Date shall
                have already occurred with respect to the Traville Facility but
                shall have not yet occurred with respect to the Manufacturing
                Facility; or

                        (b)     if a Full Recourse Event of Default has not
                occurred, (A) the Construction Period Maximum Guaranty Amount in
                the event that, as of the date of the termination of this
                Agreement, the Lease Commencement Date shall have not yet
                occurred with respect to either Property, (B) the Traville
                Construction Period Maximum Guaranty Amount in the event that,
                as of the date of the termination of this Agreement, the Lease
                Commencement Date shall have already occurred with respect to
                the Manufacturing Facility but shall have not yet

                                       13
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                occurred with respect to the Traville Facility, or (C) the
                Manufacturing Construction Period Maximum Guaranty Amount in the
                event that, as of the date of the termination of this Agreement,
                the Lease Commencement Date shall have already occurred with
                respect to the Traville Facility but shall have not yet occurred
                with respect to the Manufacturing Facility; and

                        (c)     in addition to any amounts payable pursuant to
                Section 5.1.2(i)(a) or (b), Construction Agent shall pay on the
                payment date all other Supplemental Rent then due and payable.

                (ii)    Construction Agent may at its election, within five (5)
        Business Days after such termination, exercise the option to purchase
        (or in lieu thereof, exercise its rights under Section 8.1.1(b) of the
        Participation Agreement) from Lessor (a) both Properties in the event
        that, as of the date of the termination of this Agreement, the Lease
        Commencement Date shall have not yet occurred with respect to either
        Property, (b) only the Traville Facility in the event that, as of the
        date of the termination of this Agreement, the Lease Commencement Date
        shall have already occurred with respect to the Manufacturing Facility
        but shall have not yet occurred with respect to the Traville Facility,
        or (c) only the Manufacturing Facility in the event that, as of the date
        of the termination of this Agreement, the Lease Commencement Date shall
        have already occurred with respect to the Traville Facility but shall
        have not yet occurred with respect to the Manufacturing Facility, by
        paying immediately upon such exercise an amount equal to the excess of
        (x) (1) in the event that Construction Agent exercises its option to
        purchase both Properties pursuant to clause (ii)(a) above, the aggregate
        Lease Balance, plus, without duplication, any other amounts then due and
        owing under the Operative Documents, as of the date of such payment, (2)
        in the event that Construction Agent exercises its option to purchase
        only the Traville Facility pursuant to clause (ii)(b) above, the
        Traville Lease Balance, plus, without duplication, any other amounts
        then due and owing with respect to the Traville Facility under the
        Operative Documents, as of the date of such payment, or (3) in the event
        that Construction Agent exercises its option to purchase only the
        Manufacturing Facility pursuant to clause (ii)(c) above, the
        Manufacturing Lease Balance, plus, without duplication, any other
        amounts then due and owing with respect to the Manufacturing Facility
        under the Operative Documents, as of the date of such payment, over (y)
        amounts paid by Construction Agent under clause (i) above. Unless
        Construction Agent shall have so exercised the purchase option, Lessor
        shall cause each Property to be sold in accordance with Section 5.3(a).
        If Construction Agent shall have so exercised the purchase option (and
        made all applicable payments in respect thereof), Lessor shall promptly
        convey title to the Improvements applicable to the Property or
        Properties so purchased to Lessee or their designee in accordance with
        Article XV of the Lease assuming for these purposes that said Article of
        the Lease were then applicable.

        5.2     Survival.

                (a)     The termination of this Agreement, in whole or in part,
        pursuant to Section 5.1 shall in no event relieve Construction Agent of
        their liability hereunder which accrued prior to such termination, all
        of which shall survive any such termination.

                                       14
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                (b)     Construction Agent's right to purchase one or both of
        the Properties within five (5) Business Days following the termination
        of this Agreement pursuant to Section 5.1.2 shall survive the
        termination of this Agreement until the termination of such five (5)
        Business Day period.

        5.3     Remedies Cumulative; Waivers. Upon the occurrence and
continuance of a Construction Agency Event of Default, at Lessor's option and
without limiting Lessor in the exercise of any other right or remedy Lessor may
have on account (including, without limitation, any remedies under any other
Operative Document or as set forth in Section 5.1.2), and without any further
demand or notice, but subject to Section 5.4 below and the proviso of the first
sentence of Section 5.1.2 and the second sentence of Section 5.1.2 above, Lessor
may cause the following to occur:

                (a)     Lessor shall have all the rights and may pursue any of
        the remedies hereunder with respect to Construction Period Maximum
        Guaranty Amount as are provided to it in the Lease with respect to the
        payment of Residual Value Guaranty Amount as if those provisions were
        incorporated herein including, Lessor acting as exclusive sales agent
        for the Properties. Lessor and Administrative Agent may foreclose the
        lien of the Lessee Deed of Trust on all or any portion of the Properties
        and other Collateral, including all or any of such Sites and the related
        Deed of Trust. In addition, Lessor may exercise its remedies under the
        Security Agreement.

                (b)     Lessor may continue this Agreement in effect for so long
        as Lessor shall determine, and Lessor may enforce all of Lessor's rights
        and remedies under this Agreement, and require the completion of the
        Improvements by Construction Agent as herein described, so long as
        Lessor satisfies its obligations under Section 4.1 and provides or
        otherwise obtains the funds therefor and advances such funds to
        Construction Agent.

                (c)     Lessor may terminate this Agreement at any time,
        notwithstanding a prior election under Section 5.3(b) to cause the
        completion of the Improvements with respect thereto directly through
        Lessor or one or more successor construction agents.

                (d)     Lessor may exercise any other right or remedy that may
        be available to it under Applicable Laws or in equity, or proceed by
        appropriate court action (legal or equitable) to enforce the terms or to
        recover damages for the breach hereof.

                (e)     Subject to the provisions hereof, as a matter of right
        and with notice to Construction Agent or anyone claiming under
        Construction Agent, and without regard to the then value of the
        Collateral or the interest of any Lessee therein, Lessor shall have the
        right to apply to any court having jurisdiction to appoint a receiver or
        receivers of the Collateral or any portion thereof at Lessee and
        Construction Agent's sole cost and expense (subject to Section 5.4
        hereof), and Construction Agent hereby irrevocably consents to such
        appointment and waive notice of any application therefor. Any such
        receiver or receivers shall have all the usual powers and duties of
        receivers in like or similar cases and all the powers and duties of
        Lessor in case of entry as provided in this Agreement and shall continue
        as such and exercise all such powers until the latest to

                                       15
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        occur of (i) the date of confirmation of sale of the applicable
        Collateral; (ii) the disbursement of all proceeds of such Collateral
        collected by such receiver and the payment of all expenses incurred in
        connection therewith; or (iii) the termination of such receivership with
        the consent of Lessor or pursuant to an order by a court of competent
        jurisdiction.

                (f)     To the extent permitted by, and subject to the mandatory
        requirements of, any Applicable Law, each and every right, power and
        remedy herein specifically given to Lessor or otherwise in this
        Agreement shall be cumulative and, subject to Section 5.4, shall be in
        addition to every other right, power and remedy herein specifically
        given or now or hereafter existing at law, in equity or by statute, and
        each and every right, power and remedy whether specifically herein given
        or otherwise existing may be exercised from time to time and as often
        and in such order as may be deemed expedient by Lessor, and the exercise
        or the beginning of the exercise of any power or remedy shall not be
        construed to be a waiver of the right to exercise at the same time or
        thereafter any other right, power or remedy. Lessor's consent to any
        request made by Construction Agent shall not be deemed to constitute or
        preclude the necessity for obtaining Lessor's consent, in the future, to
        all similar requests. No express or implied waiver by Lessor of any
        Construction Agency Event of Default shall in any way be, or be
        construed to be, a waiver of any future or subsequent Construction
        Agency Event of Default. To the extent permitted by any Applicable Law,
        Construction Agent hereby waives any rights now or hereafter conferred
        by statute or otherwise that may require Lessor to sell, lease or
        otherwise use the Properties, any Site, the other collateral or any part
        thereof in mitigation of Lessor's damages upon the occurrence of a
        Construction Agency Event of Default or that may otherwise limit or
        modify any of Lessor's rights or remedies under this Article V.

                (g)     No failure to exercise and no delay in exercising, on
        the part of Lessor, any right, remedy, power or privilege under this
        Agreement or under the other Operative Documents shall operate as a
        waiver thereof; nor shall any single or partial exercise of any right,
        remedy, power or privilege under this Agreement preclude any other or
        further exercise thereof or the exercise of any other right, remedy,
        power or privilege. The rights, remedies, powers and privileges provided
        in this Agreement are cumulative and not exclusive of any rights,
        remedies, powers and privileges provided by law.

                (h)     Upon termination of this Agreement as a result of a
        Construction Agency Event of Default, Construction Agent shall pay on
        behalf of Lessor to the Administrative Agent, for application in
        accordance with Article X of the Participation Agreement, in immediately
        available funds, the Construction Period Maximum Guaranty Amount.

        5.4     Limitation on Recourse Liability of Construction Agent.

                (a)     Notwithstanding anything set forth herein to the
        contrary, the aggregate amount payable by Construction Agent on a
        recourse basis under this Article V as the result of the occurrence of a
        Construction Agency Event of Default shall be subject to the limitations
        on the recourse liability of Construction Agent set forth in Section
        11.2 of the Participation Agreement.

                                       16
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                (b)     Lessor's exercise of any remedy provided hereunder or
        otherwise available at law or equity, including any demand for
        reimbursements of amounts expended by or on behalf of Lessor to cure any
        Construction Agency Event of Default shall not impair or otherwise
        reduce Construction Agent's obligation to pay the Construction Period
        Maximum Guaranty Amount and the timely application of such amount to the
        outstanding principal amount and accrued interest thereon under the Loan
        Agreement in accordance with the Participation Agreement.

        5.5     Lessor's Right to Cure Construction Agent's Defaults. Lessor,
without waiving or releasing any obligation or Construction Agency Event of
Default, may (but shall be under no obligation to) remedy any Construction
Agency Event of Default, and in furtherance of such right, Lessor may make
Advance Requests, execute Construction Documents and otherwise exercise all
rights and perform all duties of Construction Agent hereunder and Lessee under
the Participation Agreement with respect to the Construction. All reasonable out
of pocket costs and expenses so incurred (including reasonable fees and expenses
of counsel), together with interest thereon at the Overdue Rate from the date on
which such sums or expenses are paid by Lessor, shall (subject to Section 5.4
above) be funded and paid by Lessor through Advances.

        5.6     Determination of Whether Budget is "In Balance".

                (a)     If Administrative Agent determines that either the
        Approved Traville Construction Budget or the Approved Manufacturing
        Construction Budget may not be In Balance, Administrative Agent shall
        give notice to such effect to Construction Agent, together with a
        reasonably detailed explanation of the basis for Administrative Agent's
        determination and to the extent available calculations upon which
        Administrative Agent or the Construction Consultant has based its
        determination. Within ten (10) days following Construction Agent's
        receipt of such notice, Construction Agent shall deliver a certification
        to Administrative Agent that either (i) the Approved Traville
        Construction Budget or the Approved Manufacturing Construction Budget,
        as applicable, is not In Balance and describing the steps Construction
        Agent is taking to remedy such condition, if any, or (ii) the Approved
        Traville Construction Budget or the Approved Manufacturing Construction
        Budget, as applicable, is In Balance and stating sufficient detail to
        describe why Construction Agent believes the Approved Traville
        Construction Budget or the Approved Manufacturing Construction Budget,
        as applicable, is In Balance.

                (b)     If after receipt by Administrative Agent of a
        certification from Construction Agent pursuant to Section 5.6(a)(ii)
        above that the Approved Traville Construction Budget or the Approved
        Manufacturing Construction Budget, as applicable, is In Balance,
        Administrative Agent still disagrees with such certification,
        Construction Agent and Administrative Agent shall, for a period of
        thirty (30) days following Administrative Agent's receipt of such
        certification, consult with each other and use their reasonable efforts
        to resolve such dispute as to whether the applicable Construction Budget
        is In Balance.

                (c)     Upon the occurrence of either (i) Construction Agent's
        delivery of certification pursuant to Section 5.6(a)(i) above that the
        Approved Traville Construction Budget or the Approved Manufacturing
        Construction Budget, as applicable, is not In

                                       17
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        Balance, or (ii) the thirty (30) day consultation period referred to in
        Section 5.6(b) above shall expire and any Agent shall continue to
        disagree with Construction Agent's assertion that the Approved Traville
        Construction Budget or the Approved Manufacturing Construction Budget,
        as applicable, is In Balance, Lessor shall have the option, exercisable
        in its sole discretion upon notice to Construction Agent, to require
        Construction Agent to deposit (a "Balancing Deposit) with Lessor within
        five (5) Business Days an amount equal to the lesser of (x) the amount
        which if paid to Construction Agent would, together with any Available
        Commitments and Other Available Proceeds, be sufficient to make the
        Approved Traville Construction Budget or the Approved Manufacturing
        Construction Budget, as applicable, In Balance and (y) the Construction
        Period Maximum Guaranty Amount.

                (d)     In the event that Construction Agent is required to make
        a Balancing Deposit pursuant to Section 5.6(c) above, such Balancing
        Deposit shall evidence a portion of the Construction Period Maximum
        Guaranty Amount and any amounts withdrawn from the Balancing Deposit to
        fund Property Costs shall reduce dollar for dollar the Construction
        Period Maximum Guaranty Amount.

        5.7     Limitations on Construction Agent's Liability. In any action or
proceeding involving any state law, any federal bankruptcy, insolvency or
reorganization law, or any other law affecting the rights of creditors
generally, if the obligations of Construction Agent under the Operative
Documents would otherwise be held or determined to be voidable, invalid or
unenforceable as a fraudulent transfer or otherwise as a result or on account of
the amount of its liability under the Operative Documents, then, notwithstanding
any other provision hereof to the contrary, the amount of such liability shall,
without any further action by Construction Agent or any other Person, be
automatically limited and reduced to the highest amount which is valid and
enforceable.

                                   ARTICLE VI
                           NO CONSTRUCTION AGENCY FEE

        Construction Agent shall not be entitled to, and Lessor shall have no
obligation to pay, any agency fee or other fee or compensation, and no such
Person shall not be entitled to, and Lessor shall have no obligation to make or
pay, any reimbursement therefor. It being understood that this Agreement is
being entered into as consideration for and as an inducement to Lessor and the
Participants entering into the Lease and the other Operative Documents.

                                   ARTICLE VII
                                  MISCELLANEOUS

        7.1     Notices. All notices, consents, directions, approvals,
instructions, requests, demands and other communications required or permitted
by the terms hereof to be given to any Person shall be given in writing in the
manner provided in, shall be sent to the respective addresses set forth in, and
the effectiveness thereof shall be governed by the provisions of, Section 12.3
of the Participation Agreement.

                                       18
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        7.2     Successors and Assigns. This Agreement shall be binding upon and
inure to the benefit of Lessor, Construction Agent and, to the extent permitted
by the Operative Documents, their respective successors and assigns; provided,
however, that except as permitted by Sections 2.6 and 2.7 or to an entity owned
(directly or indirectly) by Construction Agent (and in either case, Construction
Agent shall remain primarily liable), Construction Agent shall not assign any of
its rights nor delegate any of its duties or obligations under this Agreement
without the prior written consent of the Administrative Agent (at the written
directions of the Directing Party) and Lessor.

        7.3     GOVERNING LAW. THIS AGREEMENT HAS BEEN DELIVERED IN, AND SHALL
IN ALL RESPECTS BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF, THE
STATE OF NEW YORK, WITHOUT REGARD TO CONFLICTS OF LAWS PRINCIPLES TO THE EXTENT
PERMITTED BY APPLICABLE LAW (EXCEPT SECTION 5-1401 OF THE NEW YORK GENERAL
OBLIGATIONS LAW), EXCEPT AS TO MATTERS RELATING TO THE CREATION OF INTERESTS IN
REAL PROPERTY OR LIENS AND THE EXERCISE OF REMEDIES WITH RESPECT TO THE PORTIONS
OF THE PROPERTIES CONSTITUTING REAL PROPERTY, WHICH SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

        7.4     Amendments, etc. In addition to the execution and delivery of
the Manufacturing Facility Supplement in accordance with Section 2.3 hereof,
Lessor and Construction Agent may, from time to time, enter into written
amendments, supplements or modifications hereto, subject to the restrictions set
forth in Section 12.5 of the Participation Agreement.

        7.5     Counterparts. This Agreement may be executed on any number of
separate counterparts and all of said counterparts taken together shall be
deemed to constitute one and the same instrument.

        7.6     Severability. Any provision of this Agreement that is prohibited
or unenforceable in any jurisdiction shall, as to such jurisdiction, be
ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

        7.7     Headings and Table of Contents. The headings and table of
contents contained in this Agreement are for convenience of reference only and
shall not limit or otherwise affect the meaning hereof.

        7.8     Exercise of Lessor's Rights. Subject to the Excluded Amounts,
Construction Agent hereby acknowledges and agrees that, subject to and in
accordance with the terms of the Security Agreement dated concurrently herewith
made by Lessor in favor of Administrative Agent, the rights and powers of Lessor
under this Agreement have been assigned to and may be exercised by
Administrative Agent in accordance with Section 12.5 of the Participation
Agreement.

                                       19
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        7.9     Limited Liability. Construction Agent agrees that Lessor's
obligations and liability under this Agreement are limited pursuant to Section
12.10 of the Participation Agreement. Except for the rights of Lessee to payment
pursuant to the express provisions of Article X of the Participation Agreement,
any rights of Construction Agent against Lessor shall be fully subordinated to
the claims of Lessor against Construction Agent until such claims are
indefeasibly paid in full.

        7.10    No Third Party Beneficiaries. Except to the extent provided in
other Operative Documents, no provision in this Agreement shall give rise to any
rights in any Person (except any Person party to an Operative Document), and
there shall be no third party beneficiaries of, and no other Persons shall be
entitled to rely on this Agreement. Any attempt by any other such Person to so
rely shall immediately be void.

        7.11    Survival of Agreements. All covenants of Construction Agent
provided for in Section 2.7(e) shall survive the termination of this Agreement.

                                  [END OF PAGE]
                            [SIGNATURE PAGES FOLLOW]

                                       20
<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

        IN WITNESS WHEREOF, the parties hereto have caused this CONSTRUCTION
AGENCY AGREEMENT to be duly executed and delivered by their proper and duly
authorized officers as of the day and year first above written.

                                         GENOME STATUTORY TRUST 2001A,
                                           as Lessor

                                         By /s/ C. SCOTT NIELSON
                                           -------------------------------------
                                         Name:  C. Scott Nielson
                                         Title: Vice President

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                                         HUMAN GENOME SCIENCES, INC.
                                         as Construction Agent

                                         By /s/ STEVEN C. MAYER
                                           -------------------------------------
                                         Name:  Steven C. Mayer
                                         Title: Senior Vice President and CFO

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                               Schedule 2.6(b)(i)

                        Traville Certain Permitted Liens

                                    Attached.

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                               Schedule 2.6(b)(ii)

                 Manufacturing Facility Certain Permitted Liens

                                    Attached.

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                                 Schedule 2.7(f)

                                    Insurance

                                    Attached.

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                                    Exhibit A

                         Traville Construction Materials

                                    Attached.

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                                    Exhibit B

                        Manufacturing Facility Supplement

                                    Attached.

<PAGE>

                                            CONSTRUCTION AGENCY AGREEMENT (HGSI)

                             Exhibit A to Exhibit B

                      Manufacturing Construction Materials

                                    Attached.

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
Section                                                                                              Page
-------                                                                                              ----
<S>                                                                                                  <C>

ARTICLE I         DEFINITIONS..........................................................................2

     1.1       Definitions; Interpretation; Amendment and Restatement..................................2

ARTICLE II        APPOINTMENT OF CONSTRUCTION AGENT....................................................2

     2.1       Appointment and Acceptance..............................................................2
     2.2       Term....................................................................................2
     2.3       Supplement to this Agreement............................................................2
     2.4       Construction Materials; Construction Documents..........................................3
     2.5       Assignment Under Construction...........................................................5
     2.6       Scope of Authority......................................................................5
     2.7       Covenants of Construction Agent.........................................................7
     2.8       Title to the Improvements...............................................................8

ARTICLE III       THE IMPROVEMENTS.....................................................................8

     3.1       Amendments; Modifications...............................................................8
     3.2       Casualty, Condemnation, Liquidated Damages and Force Majeure Events.....................8

ARTICLE IV        PAYMENT OF FUNDS....................................................................10

     4.1       Funding of Improvement Costs...........................................................10

ARTICLE V         CONSTRUCTION AGENCY EVENTS OF DEFAULT...............................................10

     5.1       Construction Agency Events of Default..................................................10
     5.2       Survival...............................................................................14
     5.3       Remedies Cumulative; Waivers...........................................................15
     5.4       Limitation on Recourse Liability of Construction Agent.................................16
     5.5       Lessor's Right to Cure Construction Agent's Defaults...................................17
     5.6       Determination of Whether Budget is "In Balance"........................................17
     5.7       Limitations on Construction Agent's Liability..........................................18

ARTICLE VI        NO CONSTRUCTION AGENCY FEE..........................................................18

ARTICLE VII       MISCELLANEOUS.......................................................................18

     7.1       Notices................................................................................18
     7.2       Successors and Assigns.................................................................19
     7.3       GOVERNING LAW..........................................................................19
     7.4       Amendments, etc........................................................................19
     7.5       Counterparts...........................................................................19
     7.6       Severability...........................................................................19
     7.7       Headings and Table of Contents.........................................................19
     7.8       Exercise of Lessor's Rights............................................................19
     7.9       Limited Liability......................................................................20
     7.10      No Third Party Beneficiaries...........................................................20
     7.11      Survival of Agreements.................................................................20
</TABLE>

                                      -i-

<PAGE>

                                TABLE OF CONTENTS
                                   (continued)

Section                                                                    Page
-------                                                                    ----

Schedule 2.6(b)(i)     -      Traville Certain Permitted Liens
Schedule 2.6(b)(ii)    -      Manufacturing Facility Certain Permitted Liens
Schedule 2.7(f)        -      Insurance Provisions

EXHIBITS

EXHIBIT A  - Traville Construction Materials:
Approved Traville Plans and Specifications
Approved Traville Construction Schedules
Approved Traville Construction Budget
Architect's Certificates

EXHIBIT B - Manufacturing Facility Supplement
     EXHIBIT A to EXHIBIT B - Manufacturing Construction Materials

                                      -ii-<PAGE>

                                                                  EXECUTION COPY

================================================================================
                                                                   Exhibit 10.20

                               SECURITY AGREEMENT

                          dated as of November 7, 2001

                                      among

                        EAGLEFUNDING CAPITAL CORPORATION
                                   as Conduit,

                             FLEET SECURITIES, INC.
              as Administrator of EagleFunding Capital Corporation,

               FLEET NATIONAL BANK and FIRST UNION NATIONAL BANK,
                             as Liquidity Providers,

       BANCBOSTON LEASING INVESTMENTS INC. and FIRST UNION NATIONAL BANK,
                                  as Investors,

                              FLEET NATIONAL BANK,
                            as Administrative Agent,

                          GENOME STATUTORY TRUST 2001A,
                                    as Lessor

                                       and
                          HUMAN GENOME SCIENCES, INC.,
                                    as Lessee

================================================================================

<PAGE>

                                                                          (HGSI)

                               SECURITY AGREEMENT

        SECURITY AGREEMENT, dated as of November 7, 2001 (this "Security
Agreement"), among EAGLEFUNDING CAPITAL CORPORATION, a Delaware corporation (the
"Conduit"), FLEET SECURITIES, INC. as Administrator of EagleFunding Capital
Corporation, (the "EagleFunding Administrator"), FLEET NATIONAL BANK and FIRST
UNION NATIONAL BANK, as Liquidity Providers (the "Liquidity Providers"),
BANCBOSTON LEASING INVESTMENTS INC. and FIRST UNION NATIONAL BANK as Investors
(the "Investors"), FLEET NATIONAL BANK as administrative agent (the
"Administrative Agent"), Lessor Hedging Agreement Counterparties and GENOME
STATUTORY TRUST 2001A, a Delaware business trust, as lessor (the "Lessor") and
HUMAN GENOME SCIENCES, INC., a Delaware corporation, as lessee and construction
agent (the "Lessee").

        WHEREAS, the Conduit intends from time to time to issue its Commercial
Paper Notes in the United States commercial paper market;

        WHEREAS, the Conduit, the Administrator, the Liquidity Providers and the
Administrative Agent have entered into a Loan Agreement pursuant to which the
Conduit may elect to lend a portion of the net proceeds of its issuance of
Commercial Paper Notes from time to time to Lessor, failing which the Liquidity
Providers have agreed to lend funds to Lessor;

        WHEREAS, pursuant to the Trust Agreement and the Participation
Agreement, the Investors have agreed to make Investor Contributions to the
Lessor;

        WHEREAS, Lessee desires by this Security Agreement and the other
Security Documents to which it is a party, among other things, to provide for
the assignment, pledge and grant of a security interest by Lessee to the
Administrative Agent for the benefit of the Lessor, among other things, in
certain of Lessee's right, title and interest in and to the Lessee Collateral
(as defined below);

        WHEREAS, Lessor desires by this Security Agreement and the other
Security Documents to which it is a party, among other things, to provide for
the assignment, pledge and grant of a security interest by Lessor to the
Administrative Agent for the benefit of the Participants and the Lessor Hedging
Agreement Counterparties, among other things, in certain of the Lessor's right,
title and interest in and to the Participant Collateral (as defined below);

        NOW THEREFORE, the parties hereto agree as follows:

                              GRANTING CLAUSE FIRST

        This Security Agreement secures the payment of all obligations of Lessee
now or hereafter existing under the Participation Agreement, the Lease and each
other Operative Document, whether for principal, interest, costs, fees, expenses
or otherwise, and all other obligations of Lessee, howsoever created, arising or
evidenced, whether direct or indirect, absolute or contingent or now or
hereafter existing or due or to become due under the Operative

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

Documents (all such obligations and other obligations of Lessee being the
"Secured Lessee Obligations").

        To secure payment and performance of the Secured Lessee Obligations,
Lessee does hereby grant, bargain, sell, assign, transfer, convey, and confirm,
unto the Administrative Agent (on behalf of the Lessor), a security interest in
and lien on all right, title and interest of Lessee in, to and under the Lessee
Collateral.

        It is expressly agreed that anything herein contained to the contrary
notwithstanding, Lessee shall remain liable under the Operative Documents to
which it is party to perform all of the obligations assumed by it thereunder,
all in accordance with and pursuant to the terms and provisions thereof, and
none of Lessor, the Administrative Agent, the Participants or any Lessor Hedging
Agreement Counterparty shall have any obligation or liability under such
Operative Documents by reason of or arising out of the assignment hereunder, nor
shall Lessor, the Administrative Agent, any Participant or any Lessor Hedging
Agreement Counterparty be required or obligated in any manner to perform or
fulfill any obligations of Lessee under or pursuant to such Operative Documents
or, except as herein expressly provided, to make any payment, or to make any
inquiry as to the nature or sufficiency of any payment received by it, or
present or file any claim, or take any action to collect or enforce the payment
of any amounts which may have been assigned to it or to which it may be entitled
at any time or times.

        Upon the occurrence and during the continuance of any Construction
Agency Event of Default or Lease Event of Default, Lessee does hereby
irrevocably constitute the Administrative Agent, on behalf of Lessor, the true
and lawful attorney-in-fact of Lessee, with full power (in the name of Lessee or
otherwise), (i) to ask for, require, demand, and receive, any and all monies and
claims for monies (in each case including insurance and requisition proceeds)
due and to become due under or arising out of the property which now or
hereafter constitutes part of the Lessee Collateral, (ii) to endorse any checks
or other instruments or orders in connection therewith and (iii) to file any
claims or to take any action or to institute any proceedings which Lessor or the
Administrative Agent may deem to be necessary or advisable with respect to the
Lessee Collateral.

                             GRANTING CLAUSE SECOND

        This Security Agreement secures the payment of all obligations of Lessor
now or hereafter existing under the Participation Agreement and each other
Operative Document, whether for principal, interest, costs, fees, expenses or
otherwise, and all other obligations of Lessor to the Participants, the Conduit
and the Lessor Hedging Agreement Counterparties, howsoever created, arising or
evidenced, whether direct or indirect, absolute or contingent or now or
hereafter existing or due or to become due (all such obligations and other
obligations of Lessor being the "Secured Lessor Obligations").

        To secure payment and performance of the Secured Lessor Obligations,
Lessor does hereby grant, bargain, sell, assign, transfer, convey, and confirm,
unto the Administrative Agent (on behalf of the Participants and the Lessor
Hedging Agreement Counterparties), a security

                                       2
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

interest in and lien on all right, title and interest of Lessor in, to and under
the following described property, rights and privileges, other than Excluded
Amounts and Excepted Rights (which collectively, excluding Excluded Amounts and
Excepted Rights, are hereinafter called the "Participant Collateral" or the
"Collateral"):

                (1)     the Lessee Collateral and all other property pledged to
        the Lessor, or in which the Lessor has been granted a security interest,
        whether pursuant to Granting Clause First above or any other Operative
        Documents or otherwise;

                (2)     all equipment of Lessor, including all parts thereof and
        all accessions, additions, attachments, improvements, substitutions and
        replacements thereto and therefor and all accessories related thereto
        (collectively referred to as the "Equipment");

                (3)     all inventory in all of its forms of Lessor, including
        (a) all raw materials and work in process therefor, finished goods
        thereof, and materials used or consumed in the manufacture or production
        thereof, (b) all goods in which Lessor has an interest in mass or a
        joint or other interest or right of any kind (including goods in which
        Lessor has an interest or right as consignee), and (c) all goods which
        are returned to or repossessed by Lessor, and all accessions thereto,
        products thereof and documents therefor (all of the foregoing
        collectively referred to as the "Inventory");

                (4)     the Participation Agreement and an original executed
        counterpart of the Lease to which a chattel paper receipt is attached,
        including the security interest granted thereunder in favor of Lessor
        and including all rights to receive payments thereunder (including Rent)
        other than Excluded Amounts;

                (5)     the Security Documents, the Material Construction
        Contracts and the other Operative Documents;

                (6)     all accounts, contracts, contract rights, chattel paper,
        documents, instruments, and general intangibles (including tax refunds)
        of Lessor, whether or not arising out of or in connection with the sale
        or lease of goods or the rendering of services, and all rights of Lessor
        now or hereafter existing in and to all security agreements, guaranties,
        leases and other contracts securing or otherwise relating to any such
        accounts, contracts, contract rights, chattel paper, documents,
        instruments, and general intangibles (all of the foregoing collectively
        referred to as the "Receivables", and any and all such security
        agreements, guaranties, leases and other contracts collectively referred
        to as the "Related Contracts");

                (7)     all books, records, writings, databases, information and
        other property relating to, used or useful in connection with,
        evidencing, embodying, incorporating or referring to, any of the
        foregoing (to the extent there are no restrictions at law or contract on
        the assignment contemplated herein);

                                       3
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                (8)     all books, records, writings, databases, information and
        other property relating to, used or useful in connection with,
        evidencing, embodying, incorporating or referring to, any of the
        foregoing (to the extent there are no restrictions at law or contract on
        the assignment contemplated herein);

                (9)     all rights to exercise remedies under the Lease (other
        than relating to Excluded Amounts of Excepted Rights); and

                (10)    all products, accessions, rents, issues, profits,
        returns, income and proceeds of and from any and all of the foregoing
        Participant Collateral (including proceeds which constitute property of
        the types described in the foregoing clauses of this Granting Clause
        Second, proceeds deposited from time to time in any lockboxes of Lessor,
        and, to the extent not otherwise included, all payments under insurance
        (whether or not the Administrative Agent is the loss payee thereof), or
        any indemnity, warranty or guaranty payable by reason of loss or damage
        to or otherwise with respect to any of the foregoing Participant
        Collateral).

        Lessor hereby assigns, transfers and conveys to the Administrative Agent
for the benefit of the Participants and the Lessor Hedging Agreement
Counterparties all payments (except Excluded Amounts) payable by Lessee under
the Lease and all amounts payable to it by Construction Agent under the
Construction Agency Agreement.

        It is expressly agreed that anything herein contained to the contrary
notwithstanding, Lessor shall remain liable under the Operative Documents to
which it is party to perform all of the obligations assumed by it thereunder,
all in accordance with and pursuant to the terms and provisions thereof, and
none of the Participants, the Administrative Agent or any Lessor Hedging
Agreement Counterparty shall have any obligation or liability under such
Operative Documents by reason of or arising out of the assignment hereunder, nor
shall the Participants, the Administrative Agent or any Lessor Hedging Agreement
Counterparty be required or obligated in any manner to perform or fulfill any
obligations of Lessor under or pursuant to such Operative Documents or, except
as herein expressly provided, to make any payment, or to make any inquiry as to
the nature or sufficiency of any payment received by it, or present or file any
claim, or take any action to collect or enforce the payment of any amounts which
may have been assigned to it or to which it may be entitled at any time or
times.

        Lessor does hereby irrevocably constitute the Administrative Agent (on
behalf of the Participants and the Lessor Hedging Agreement Counterparties) the
true and lawful attorney-in-fact of Lessor, with full power (in the name of
Lessor or otherwise), other than with respect to Excepted Rights and Excluded
Amounts, (i) to ask for, require, demand, and receive, any and all monies and
claims for monies (in each case including insurance and requisition proceeds)
due and to become due under or arising out of the Operative Documents to which
Lessor is party, and all other property which now or hereafter constitutes part
of the Participant Collateral, (ii) to endorse any checks or other instruments
or orders in connection therewith and (iii) to file any claims or to take any
action or to institute any proceedings which the Participants, the
Administrative Agent or any Lessor Hedging Agreement Counterparty may deem to be

                                       4
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

necessary or advisable. Under the Lease and the Participation Agreement, Lessee
is directed to make all payments of Rent (other than Excluded Amounts) and all
other amounts which are required to be paid to Lessor pursuant to the Lease
(other than Excluded Amounts) directly to the Administrative Agent in accordance
with the provisions of Article II, for application as provided in this Security
Agreement and the Participation Agreement.

        Concurrently with the delivery hereof, Lessor is delivering to the
Administrative Agent the original executed counterpart of the Lease (to which a
chattel paper receipt is attached) which it received from Lessee.

        Each of Lessee and Lessor agrees that at any time and from time to time,
upon the written request of the Administrative Agent, each of Lessee and Lessor
will promptly and duly execute and deliver or cause to be duly executed and
delivered any and all such further instruments and documents as the
Administrative Agent may reasonably deem necessary in obtaining the full
benefits of the assignment hereunder and of the rights and powers herein
granted.

        Each of Lessee and Lessor hereby warrants and represents that:

        (A)     it has not assigned or pledged, and hereby covenants that it
will not assign or pledge, so long as this Security Agreement shall remain in
effect, any of its right, title or interest hereby assigned, to anyone other
than (i) in the case of Lessee, to the Lessor and the Administrative Agent on
behalf of Lessor, and (ii) in the case of Lessor, to the Participants and the
Lessor Hedging Agreement Counterparties, and the Administrative Agent for the
benefit of Participants and the Lessor Hedging Agreement Counterparties, and

        (B)     Lessor will not, except as provided in this Security Agreement
and any other Operative Documents or except with the consent of the
Administrative Agent, (i) accept any payment from Lessee, (ii) enter into any
agreement amending or supplementing the Lease, the Participation Agreement or
any other Operative Document to which it is party, (iii) execute any waiver or
modification of, or consent under, the terms of, or (except with respect to its
Excluded Amounts and subject to its Excepted Rights) exercise any rights, power
or privileges under, the Lease, the Participation Agreement or any other
Operative Document to which it is party, or (iv) settle or compromise any claim
arising under the Lease or the Participation Agreement.

        Lessor hereby ratifies and confirms each Operative Document to which it
is party and hereby agrees that it will not take or omit to take any action, the
taking or omission of which might result in an alteration or impairment of any
such Operative Document or this Security Agreement or of any of the rights
created by any such document or the assignment hereunder.

        IT IS HEREBY COVENANTED AND AGREED by and between the parties hereto as
follows:

                                       5
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                   ARTICLE I

             DEFINITIONS; APPOINTMENT OF ADMINISTRATIVE AGENT, ETC.

        SECTION 1.01    Definitions. Unless otherwise defined herein,
capitalized terms shall have the meaning ascribed to them in Appendix A to the
Participation Agreement, dated as of even date herewith, among the Lessor, the
Lessee, the Investors, the Administrative Agent, the Liquidity Agent, the
Conduit, the Administrator, the Liquidity Providers and Wells Fargo Bank,
Northwest, N.A., as trustee for the Lessor and the rules of usage set forth
therein shall apply hereto.

        SECTION 1.02    Appointment of Administrative Agent, etc. (a) Each of
the Lessor, and the Participants hereby appoints Fleet National Bank as the
Administrative Agent and hereby presently transfers to the Administrative Agent
all rights of the Lessor, the Participants and the Lessor Hedging Agreement
Counterparties under this Security Agreement, including all right, title and
interest of Lessee or Lessor in and to the applicable Collateral (including all
payments payable by Lessee under the Lease), except for Excluded Amounts and
Excepted Rights. The parties agree that the Administrative Agent is holding the
original executed counterpart of the Lease, as bailee pursuant to Section 9-313
of the UCC. The Administrative Agent acknowledges that it has been notified of
the security interests granted in this Security Agreement in the original
executed counterpart of the Lease. Proceeds of the Collateral shall be
distributed by the Administrative Agent in accordance with Article X of the
Participation Agreement.

        (b)     Lessee hereby acknowledges such appointment and the transfer of
rights of the Lessor to the Administrative Agent under this Security Agreement.
Lessor hereby acknowledges such appointment and the transfer of rights of the
Participants to the Administrative Agent under this Security Agreement.

                                   ARTICLE II

                                 RENT PAYMENTS

        SECTION 2.01    Payment of Rent and Other Amounts. Pursuant to this
Security Agreement, all of the payments (other than Excluded Amounts) made by
Lessee under the Operative Documents have been assigned to the Administrative
Agent. Lessee shall pay or cause to be paid each installment of the Base Rent,
Supplemental Rent, and other amounts payable under the Lease and the Operative
Documents, (excluding, in each case, Excluded Amounts and subject, in each case,
to Excepted Rights) to the Administrative Agent. At the appropriate times, the
Conduit and Lessor shall instruct all other Persons who may come to owe to the
Participants, the Lessor Hedging Agreement Counterparties or Lessor amounts
pursuant to the Lease or any other Operative Document to pay such amounts
(excluding, in each case, Excluded Amounts and subject, in each case, to
Excepted Rights) and each of the Participants and Lessor shall use reasonable
efforts to cause all such Persons to make all such payments to the
Administrative Agent.

                                       6
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

        SECTION 2.02    Payments from Collateral Only. Without impairing any of
the other rights, powers, privileges, liens or security interests of the
Participants, the Lessor Hedging Agreement Counterparties or the Administrative
Agent under this Security Agreement or any other Operative Document, each
Participant and the Lessor Hedging Agreement Counterparties agree that, except
as expressly provided in this Security Agreement, the Trust Agreement, the Loan
Agreement, the Participation Agreement, the Liquidity Agreement or any other
Operative Document, (i) the obligation of Lessor to make all payments under the
Lease, and the performance by Lessor of every obligation or covenant contained
in this Security Agreement, the Participation Agreement, or any of the other
Operative Documents, shall be payable only from the income and proceeds of
Lessor to the extent included in the Participant Collateral or any other
collateral pledged by Lessor under the Security Documents and only to the extent
that Lessor shall have sufficient income or proceeds to the extent included in
the Participant Collateral to enable the Administrative Agent to make such
payments in accordance with the terms of Article X of the Participation
Agreement, and all of the statements, representations, covenants and agreements
made by Lessor contained in this Security Agreement and any agreement referred
to herein, unless expressly otherwise stated, are made and intended only for the
purpose of binding Lessor and establishing the existence of rights and remedies
which can be exercised and enforced against Lessor; therefore, anything
contained in this Security Agreement or such other agreements to the contrary
notwithstanding, no recourse shall be had with respect to this Security
Agreement or such other Operative Documents against Lessor, except to the extent
of such Participant Collateral, or against any officer, director, trustee,
servant, partner, member or direct or indirect parent or controlling person or
persons of Lessor; and (ii) none of Lessor or the Administrative Agent shall
have any personal liability for any amounts payable hereunder, under the
Participation Agreement or any of the other Operative Documents (except, in the
case of Lessor, to the extent of such Participant Collateral); provided,
however, that this Section 2.02 shall not be construed to prohibit any action or
proceeding against any party hereto for its own willful misconduct, gross
negligence, bad faith or criminal conduct for which it would otherwise be liable
(but only to the extent of the damages arising by reason thereof). Lessor hereby
acknowledges that the Administrative Agent has expressly reserved all its legal
rights and remedies against the Participant Collateral granted by Lessor,
including, without limitation of the generality of the foregoing, the right, in
the event of any payment due and unpaid from Lessor under the Loan Agreement, to
foreclose upon this Security Agreement and/or to receive the proceeds from the
Participant Collateral and otherwise to enforce any other right under this
Security Agreement.

                                   ARTICLE III

                      RECEIPT, DISTRIBUTION AND APPLICATION
                          OF INCOME FROM THE COLLATERAL

        SECTION 3.01    Distribution. Distributions of payments and collateral
proceeds shall be distributed in the manner set forth in Article X of the
Participation Agreement.

                                       7
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                   ARTICLE IV

             REMEDIES OF ADMINISTRATIVE AGENT UPON EVENT OF DEFAULT

        SECTION 4.01    Remedies Upon Default. If any Lease Event of Default or
Construction Agency Event of Default shall have occurred and be continuing the
Administrative Agent may exercise in respect of the Collateral, in addition to
other rights and remedies provided for herein or otherwise available to it, all
the rights and remedies of a secured party under the UCC (whether or not the UCC
applies to the Collateral at issue), and the Administrative Agent may also,
without notice except as specified below, sell the Collateral or any part
thereof in one or more parcels at public or private sale, or at any of the
Administrative Agent's offices or elsewhere, for cash, on credit or for future
delivery, and upon such other terms as the Administrative Agent may deem
commercially reasonable. Lessor agrees that, to the extent notice of sale shall
be required by law, at least ten days' notice to Lessor of the time and place of
any public sale or the time after which a private sale is to be made shall
constitute reasonable notification. The Administrative Agent shall not be
obligated to make any sale of Collateral regardless of notice of sale having
been given. The Administrative Agent may adjourn any public or private sale from
time to time by announcement at the time and place fixed therefore and such sale
may, without further notice, be made at the time and place to which it was so
adjourned. The Administrative Agent shall be entitled to consult with legal
counsel and financial advisors in connection with the sale of the Collateral and
shall be protected in any reasonable action or forbearance taken in connection
with the advice of such counsel or advisors.

        SECTION 4.02    Remedies Cumulative. Each and every right, power and
remedy given to the Administrative Agent specifically or otherwise in this
Security Agreement shall be cumulative and shall be in addition to every other
right, power and remedy herein specifically given or now or hereafter existing
at law, or under the UCC, or otherwise in equity or by statute, and each and
every right, power and remedy whether specifically herein given or otherwise
existing may be exercised from time to time and as often and in such order as
may be deemed expedient by the Administrative Agent, and the exercise or the
beginning of the exercise of any power or remedy shall not be construed to be a
waiver of the right to exercise at the same time or thereafter any other right,
power or remedy. No delay or omission by the Administrative Agent in the
exercise of any right, remedy or power or in the pursuance of any remedy shall
impair any such right, power or remedy or be construed to be a waiver of any
default on the part of Lessor or Lessee or to be an acquiescence therein.

        SECTION 4.03    Discontinuance of Proceedings. In case the
Administrative Agent shall have instituted any proceeding to enforce any right,
power or remedy under this Security Agreement by foreclosure, entry or
otherwise, and such proceedings shall have been discontinued or abandoned for
any reason or shall have been determined adversely to the Administrative Agent,
then and in every such case the Participants, the Lessor Hedging Agreement
Counterparties, the Administrative Agent, Lessee and Lessor shall, subject to
any determination in such proceedings, be restored to their former positions and
rights hereunder with respect to the Collateral, and all rights, remedies and
powers of the Administrative Agent shall continue as if no such proceedings had
been instituted.

                                       8
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                   ARTICLE V

                  THE PARTICIPANTS AND THE ADMINISTRATIVE AGENT

        SECTION 5.01    No Representations or Warranties as to Property or
Documents. NONE OF THE PARTICIPANTS, THE LESSOR HEDGING AGREEMENT
COUNTERPARTIES, OR LESSOR MAKES OR SHALL BE DEEMED TO HAVE MADE ANY
REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, AS TO THE TITLE, VALUE,
COMPLIANCE WITH SPECIFICATIONS, CONDITION, DESIGN, QUALITY, DURABILITY,
OPERATION, MERCHANTABILITY OR FITNESS FOR USE OR PURPOSE OF ANY PROPERTY, OR ANY
OTHER REPRESENTATION OR WARRANTY WITH RESPECT TO ANY PROPERTY WHATSOEVER. None
of the Participants, the Lessor Hedging Agreement Counterparties, or Lessor
makes or shall be deemed to have made any representations or warranty as to the
validity, legality or enforceability of this Security Agreement, the Loan
Agreements, the Notes, the Participation Agreement, the Lease or any other
Operative Document as to the correctness of any statement contained in any
thereof, except for the representations and warranties of Lessor made in Section
5.3 of the Participation Agreement. The Administrative Agent makes no
representation or warranty hereunder whatsoever.

        SECTION 5.02    Loss of Principal or Interest. The Administrative Agent
shall not be liable for any loss of principal or interest resulting from a
Permitted Investment, provided, that any payments received or applied hereunder
by the Administrative Agent shall be accounted for by the Administrative Agent
so that any portion thereof paid or applied pursuant hereto shall be
identifiable as to the source thereof.

        SECTION 5.03    Reliance; Administrative Agent; Advice of Counsel. The
Administrative Agent shall not incur any liability to anyone in acting upon any
signature, instrument, notice, resolution, request, consent, order, certificate,
report, opinion, bond or other document or paper believed by it to be genuine
and believed by it to be signed by the proper party or parties. The
Administrative Agent may accept a copy of a resolution of the board of directors
or general manager of any party to the Participation Agreement, certified by the
Secretary or an Assistant Secretary thereof as duly adopted and in full force
and effect, as conclusive evidence that such resolution has been duly adopted
and that the same is in full force and effect. As to any fact or matter relating
to Lessee or Lessor the manner of ascertainment of which is not specifically
described herein, the Participants, the Lessor Hedging Agreement Counterparties,
or the Administrative Agent may for all purposes hereof rely on a certificate,
signed by a duly authorized officer of Lessee or Lessor, as to such fact or
matter, and such certificate shall constitute full protection to the
Participants, the Lessor Hedging Agreement Counterparties, or the Administrative
Agent for any action taken or omitted to be taken by them in good faith in
reliance thereon.

                                       9
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                   ARTICLE VI

                                  MISCELLANEOUS

        SECTION 6.01    Termination of Security Agreement. This Security
Agreement shall remain in full force and effect until payment in full of the
Lease Balance and all other amounts due and payable by the Lessee under the
Operative Documents and the termination of the Commitments of the Participants,
provided, however, that this Security Agreement and the security interests
created hereby shall earlier terminate and this Security Agreement shall be of
no further force or effect upon any sale or other final disposition by the
Administrative Agent of all of the property constituting the Collateral and the
final distribution by the Administrative Agent of all monies or other property
or proceeds constituting the Collateral in accordance with the terms hereof.
Upon such termination of this Security Agreement, the Participants shall direct
the Administrative Agent to execute and deliver to or as directed in writing by
the Lessor, an appropriate instrument terminating this Security Agreement and
releasing Collateral from the assignment and pledge thereof hereunder, and the
Administrative Agent shall execute and deliver such instrument as aforesaid.
Except as aforesaid otherwise provided, this Security Agreement and the security
interests created hereby shall continue in full force and effect in accordance
with the terms hereof.

        SECTION 6.02    Sale of Collateral by Administrative Agent Is Binding.
Any sale or other conveyance of any Lessee Collateral or the Participant
Collateral by the Administrative Agent made pursuant to the terms of this
Security Agreement or the Lease shall be effective to transfer or convey all
right, title and interest of the Lessee or Lessor, as applicable, in and to such
Collateral. No purchaser or other grantee shall be required to inquire as to the
authorization, necessity, expediency or regularity of such sale or conveyance or
as to the application of any sale or other proceeds with respect thereto by the
Administrative Agent.

        SECTION 6.03    Security Agreement for Benefit of the Lessor,
Participants, Lessor Hedging Agreement Counterparties and the Administrative
Agent. Except as provided by Applicable Law or otherwise expressly provided in
the Operative Documents, nothing in this Security Agreement, whether express or
implied, shall be construed to give any legal or equitable right, remedy or
claim under or in respect of this Security Agreement to any Person other than
Lessor, the Participants, the Administrative Agent and the Lessor Hedging
Agreement Counterparties.

        SECTION 6.04    Notices. All notices, demands, requests, consents,
approvals and other instruments under this Security Agreement shall be made in
accordance with the notice provisions of the Participation Agreement.

        SECTION 6.05    Severability. Any provision of this Security Agreement
which is prohibited or unenforceable in any jurisdiction, shall, as to such
jurisdiction, be ineffective to the extent of such prohibition or
unenforceability without invalidating the remaining provisions hereof, and any
such prohibition or unenforceability in any jurisdiction shall not invalidate or
render unenforceable such provision in any other jurisdiction.

                                       10
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

        SECTION 6.06    No Oral Modification or Continuing Waivers. No term or
provision of this Security Agreement may be changed, waived, discharged or
terminated orally, but only by an instrument in writing signed by the party or
other person against whom enforcement of the change, waiver, discharge or
termination is sought and then only in accordance with Section 12.5 of the
Participation Agreement.

        SECTION 6.07    Successors and Assigns. All covenants and agreements
contained herein shall be binding upon, and inure to the benefit of, each of the
parties hereto and the successors and assigns of each, all as herein provided.

        SECTION 6.08    Headings. The headings of the various Articles and
Sections herein and in the table of contents hereto are for convenience of
reference only and shall not define or limit any of the terms or provisions
hereof.

        SECTION 6.09    Governing Law; Counterpart Form. This Security Agreement
and the rights and obligations of the parties under this Security Agreement
shall be governed by, and construed and interpreted in accordance with, the laws
of the State of New York, including Section 5-1401 of the New York General
Obligations Law, but excluding to the maximum extent permitted by Applicable Law
all other conflicts of law principles and choice of law rules of New York. This
Security Agreement may be executed by the parties hereto in separate
counterparts, each of which when so executed and delivered shall be an original,
but all such counterparts shall together constitute but one and the same
instrument.

        SECTION 6.10    Continuing Security Interest. This Security Agreement
creates a continuing security interest in the Collateral.

                                  [End of Page]

                            [Signature Pages Follow]

                                       11
<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

        IN WITNESS WHEREOF, the parties hereto have caused this SECURITY
AGREEMENT to be duly executed by their respective officers thereunto duly
authorized, as of the day and year first above written.

                                      EAGLEFUNDING CAPITAL CORPORATION

                                      By: /s/ THOMAS M. CALHOUN
                                          ----------------------------------
                                          Name:  Thomas M. Calhoun
                                          Title: Director, its
                                                 attorney-in-fact

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      FLEET SECURITIES, INC.

                                      By: /s/ THOMAS M. CALHOUN
                                          ----------------------------------
                                          Name:  Thomas M. Calhoun
                                          Title: Director

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      FLEET NATIONAL BANK, as Liquidity Provider

                                      By:  /s/ THOMAS W. DAVIES
                                          ----------------------------------
                                          Name:  Thomas W. Davies
                                          Title: Managing Director

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      FIRST UNION NATIONAL BANK, as Liquidity
                                      Provider

                                      By: /s/ BARBARA K. ANGEL
                                          ----------------------------------
                                          Name:  Barbara Kaufmann Angel
                                          Title: Vice President

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      BANCBOSTON LEASING INVESTMENTS INC.,
                                      as Investor

                                      By:  /s/ STEVEN CRISCIONE
                                          ----------------------------------
                                          Name:  Steven Criscione
                                          Title: Vice President

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      FIRST UNION NATIONAL BANK, as Investor

                                      By: /s/ BARBARA K. ANGEL
                                          ----------------------------------
                                          Name:  Barbara Kaufmann Angel
                                          Title: Vice President

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      FLEET NATIONAL BANK, as Administrative
                                      Agent

                                      By: /s/ THOMAS W. DAVIES
                                          ----------------------------------
                                          Name:  Thomas W. Davies
                                          Title: Managing Director

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      GENOME STATUTORY TRUST 2001A, as Lessor

                                      By:  /s/ C. SCOTT NIELSON
                                          ----------------------------------
                                          Name:  C. Scott Nielson
                                          Title: Vice President

<PAGE>

                                                       SECURITY AGREEMENT (HGSI)

                                      HUMAN GENOME SCIENCES, INC., as Lessee

                                      By: /s/ STEVEN C. MAYER
                                          ----------------------------------
                                          Name:  Steven C. Mayer
                                          Title: Senior Vice President and CFO

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                         PAGE
<S>                                                                                                     <C>

ARTICLE I    DEFINITIONS; APPOINTMENT OF ADMINISTRATIVE AGENT, ETC.........................................6

     SECTION 1.01    Definitions...........................................................................6
     SECTION 1.02    Appointment of Administrative Agent, etc..............................................6

ARTICLE II   RENT PAYMENTS.................................................................................6

     SECTION 2.01    Payment of Rent and Other Amounts.....................................................6
     SECTION 2.02    Payments from Collateral Only.........................................................7

ARTICLE III  RECEIPT, DISTRIBUTION AND APPLICATION OF INCOME FROM THE COLLATERAL...........................7

     SECTION 3.01    Distribution..........................................................................7

ARTICLE IV   REMEDIES OF ADMINISTRATIVE AGENT UPON EVENT OF DEFAULT........................................8

     SECTION 4.01    Remedies Upon Default.................................................................8
     SECTION 4.02    Remedies Cumulative...................................................................8
     SECTION 4.03    Discontinuance of Proceedings.........................................................8

ARTICLE V    THE PARTICIPANTS AND THE ADMINISTRATIVE AGENT.................................................9

     SECTION 5.01    No Representations or Warranties as to Property or Documents..........................9
     SECTION 5.02    Loss of Principal or Interest.........................................................9
     SECTION 5.03    Reliance; Administrative Agent; Advice of Counsel.....................................9

ARTICLE VI   MISCELLANEOUS................................................................................10

     SECTION 6.01    Termination of Security Agreement....................................................10
     SECTION 6.02    Sale of Collateral by Administrative Agent Is Binding................................10
     SECTION 6.03    Security Agreement for Benefit of the Lessor, Participants,
                     Lessor Hedging Agreement Counterparties and the Administrative Agent.................10
     SECTION 6.04    Notices..............................................................................10
     SECTION 6.05    Severability.........................................................................10
     SECTION 6.06    No Oral Modification or Continuing Waivers...........................................11
     SECTION 6.07    Successors and Assigns...............................................................11
     SECTION 6.08    Headings.............................................................................11
     SECTION 6.09    Governing Law; Counterpart Form......................................................11
     SECTION 6.10    Continuing Security Interest.........................................................11
</TABLE>

                                      -i-

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