Document:

First Supplemental Indenture

 Exhibit 4.1 
 INFINITY PROPERTY AND CASUALTY CORPORATION 
 and 

U.S. BANK NATIONAL ASSOCIATION, 
 as Trustee 
 FIRST SUPPLEMENTAL INDENTURE 

Dated as of September 17, 2012 
 to 
 SENIOR INDENTURE 

Dated as of August 6, 2010 
 5.000% Senior Notes due 2022 

 FIRST SUPPLEMENTAL INDENTURE, dated as of the 17 day of September, 2012 (this “FIRST
SUPPLEMENTAL INDENTURE”), between Infinity Property and Casualty Corporation, a corporation duly organized and existing under the laws of the State of Ohio (hereinafter sometimes referred to as the “Company”), and
U.S. Bank National Association, a national banking association as trustee (hereinafter sometimes referred to as the “Trustee”) under the Senior Indenture dated as of August 6, 2010 between the Company and the Trustee
(the “Indenture”). 
 WHEREAS, the Company executed and delivered the Indenture to the Trustee to provide for the future
issuance of its debt securities (the “Securities”), which Securities are to be issued from time to time in such series as may be determined by the Company under the Indenture, in an unlimited aggregate principal amount which may be
authenticated and delivered thereunder as in the Indenture provided; and 
 WHEREAS, the Indenture is incorporated herein by this
reference; and 
 WHEREAS, pursuant to the terms of the Indenture, the Company desires to provide for the establishment of a new series
of its Securities to be known as its 5.000% Senior Notes due 2022 (such series being hereinafter referred to as the “5.000% Senior Notes”), the form and substance of such 5.000% Senior Notes and the terms, provisions and conditions
thereof to be set forth as provided in the Indenture and this First Supplemental Indenture; and 
 WHEREAS, the Company desires and has
requested the Trustee to join with it in the execution and delivery of this First Supplemental Indenture, and all requirements necessary to make this First Supplemental Indenture a valid instrument, in accordance with its terms, and to make the
5.000% Senior Notes, when executed by the Company and authenticated and delivered by the Trustee, the valid obligations of the Company, have been performed and fulfilled, and the execution and delivery hereof have been in all respects duly
authorized; 
 NOW, THEREFORE, in consideration of the purchase and acceptance of the 5.000% Senior Notes by the holders thereof, and for
the purpose of setting forth, as provided in the Indenture, the form and substance of the 5.000% Senior Notes and the terms, provisions and conditions thereof, the Company covenants and agrees with the Trustee as follows: 

Article One 

Additional Definitions 

Section 1.01. For all purposes of this First Supplemental Indenture, capitalized terms used herein without definition shall have the meanings
specified in the Indenture. 
 Section 1.02. The terms defined in this Section, for all purposes of this First Supplemental
Indenture, shall have the respective meanings specified in this Section. 
 “Adjusted Treasury Rate” means, with respect to any
date of redemption, the rate per year equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the
Comparable Treasury Price for that date of redemption. 
 “Capital Stock” of any Person means any and all shares, interests,
units, participations or other equivalents (however designated) of corporate stock or other equity of such Person. 
 “Comparable
Treasury Issue” means the United States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities to be redeemed that would be used, at the time of selection and under
customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the 5.000% Senior Notes. 
 “Comparable Treasury Price” means, with respect to any date of redemption, the average of the Reference Treasury Dealer Quotations for the date of redemption, after excluding the highest
and lowest Reference Treasury Dealer Quotations, or if the Quotation Agent obtains fewer than three Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations. 

“Lien” means, with respect to any property or assets, any mortgage, pledge, security interest, lien, conditional sale or other title
retention agreement or other similar encumbrance. 

 “Quotation Agent” means Barclays Capital Inc. and Goldman and Sachs & Co., or
another Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer” means Barclays Capital Inc. and
Goldman, Sachs & Co., and their respective successors and, at the Company’s option, other nationally recognized investment banking firms that are primary dealers of U.S. government securities in New York City. If any of the foregoing
ceases to be a primary dealer of U.S. government securities in New York City, the Company must substitute another primary dealer of U.S. government securities. 
 “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any date of redemption, the average, as determined by the Quotation Agent, of the bid and
asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Quotation Agent by the Reference Treasury Dealer at 5:00 p.m., New York City time, on the third business day
before the date of redemption. 
 “Stated Maturity” means September 19, 2022. 

“Voting Stock” means stock of any class or classes or other ownership interest having general voting power under ordinary circumstances
to elect a majority of the board of directors, managers, trustees or persons with similar functions of the entity in question, provided that, for the purposes of this definition, stock which carries only the right to vote conditionally on the
happening of an event will not be considered Voting Stock whether or not that event has happened. 
 “Wholly Owned Subsidiary”
means, at any time, a Subsidiary all of the outstanding Capital Stock of which (other than directors’ qualifying shares) shall at such time be owned, directly or indirectly, by the Company, one or more Wholly Owned Subsidiaries or the Company
and one or more Wholly Owned Subsidiaries. 
 Article Two 

General Terms and Conditions of 
 the 5.000% Senior Notes 
 Section 2.01. There is hereby established, and
authenticated and delivered by the Trustee on the date hereof, a series of Securities designated the “5.000% Senior Notes” limited in aggregate principal amount to $275,000,000. The 5.000% Senior Notes shall mature and the principal shall
be due and payable, together with all accrued and unpaid interest thereon, on the Stated Maturity, subject to the provisions of the Indenture relating to the acceleration of maturity. The 5.000% Senior Notes shall be issued in fully registered form
without coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof. The 5.000% Senior Notes shall be issued in the form set forth in Exhibit A hereto. 
 Section 2.02. The 5.000% Senior Notes shall be issued in the form of one or more Registered Global Securities and registered in the name of the Depository (which shall be The Depository Trust
Company) or its nominee. 5.000% Senior Notes represented by a Global Security will not be exchangeable for, and will not otherwise be issuable as, 5.000% Senior Notes in certificated form, except as may be provided in Sections 2.7 or 2.12 of the
Indenture and except if there shall have occurred and be continuing an Event of Default and the holders of a majority in aggregate principal amount of 5.000% Senior Notes determine to discontinue the system of book-entry transfers through the
Depository. Any Global Security that is exchangeable pursuant to the preceding sentence shall be exchangeable for 5.000% Senior Notes registered in such names as the Depository shall direct. 
 Section 2.03. The Registered Global Securities described above may not be transferred except by the Depository to a nominee of the Depository or by a nominee of the Depository to the
Depository or another nominee of the Depository or to a successor Depository or its nominee. 
 Owners of beneficial interests in such
Registered Global Securities will not be considered the holders thereof for any purpose under the Indenture, and no Global Security representing a 5.000% Senior Note shall be exchangeable, except for another Global Security of like denomination and
tenor to be registered in the name of the Depository or its nominee or to a successor Depository or its nominee. The rights of holders of such Registered Global Securities shall be exercised only through the Depository. 

 Section 2.04. Each 5.000% Senior Note will bear interest at the rate of 5.000% per annum from
and including the date of original issuance or from the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for until the principal thereof becomes due and payable, and on any overdue principal and
(to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. Interest shall be paid semi-annually in arrears on March 19 and September 19 of each year (each, an
“Interest Payment Date”), commencing on March 19, 2013 to the person in whose name such 5.000% Senior Note or any predecessor 5.000% Senior Note is registered at the close of business on the last of the month preceding the month in
which such Interest Payment Date occurs (the “Record Date”), provided that the interest payable at the Stated Maturity will be paid to the person to whom principal is payable. Any such interest installment not punctually paid or
duly provided for on any Interest Payment Date shall forthwith cease to be payable to the registered holder on the relevant Record Date, and may be paid to the person in whose name the 5.000% Senior Note (or one or more predecessor Securities) is
registered at the close of business on a special record date to be fixed by the Trustee for the payment of such defaulted interest, notice whereof shall be given to the registered holders of the 5.000% Senior Notes not less than 10 days prior to
such special record date, or may be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the 5.000% Senior Notes may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in the Indenture. 
 The amount of interest payable for any period will be computed on the basis of a
360-day year of twelve 30-day months and, for any period shorter than a full calendar month, on the basis of the actual number of days elapsed in such period. In the event that any date on which interest is payable on the 5.000% Senior Notes is not
a Business Day, then payment of interest payable on such date will be made on the next succeeding day that is a Business Day (and without any interest or other payment in respect of any such delay), except that, if such Business Day is in the next
succeeding calendar year, such payment shall be made on the immediately preceding Business Day (and without any reduction in interest or other payment in respect of any such early payment), in each case with the same force and effect as if made on
the date such payment was originally payable. 
 Payment of the principal and interest due at the Stated Maturity of the 5.000% Senior Notes
shall be made upon surrender of the 5.000% Senior Notes at the Corporate Trust Office. The principal of and interest on the 5.000% Senior Notes shall be paid in such coin or currency of the United States of America as at the time of payment is legal
tender for payment of public and private debts. Payments of interest (including interest on any Interest Payment Date) will be made, subject to such surrender where applicable, at the option of the Company, (i) by check mailed to the address of
the person entitled thereto as such address shall appear in the Security Register or (ii) by wire transfer in immediately available funds at such place and to such account at a banking institution in the United States as may be designated in
writing to the Trustee at least 14 days prior to the date for payment by the person entitled thereto. 
 Section 2.05. The 5.000%
Senior Notes will be senior unsecured obligations of the Company and will rank equally in right of payment with all of the other senior unsecured, unguaranteed and unsubordinated indebtedness of the Company from time to time outstanding. The 5.000%
Senior Notes will rank senior to any subordinated indebtedness of the Company. 
 Section 2.06. The Company will not, and will not
permit any Subsidiary to, incur, issue, assume or Guarantee any Indebtedness if such Indebtedness is secured by Lien on any shares of Voting Stock of any Significant Subsidiary, whether such Voting Stock is now owned or shall hereafter be acquired,
without providing that the Securities (together with, if the Company shall so determine, any other Indebtedness or obligations of the Company or any Subsidiary ranking equally with such Securities and then existing or thereafter created) shall be
secured equally and ratably with such Indebtedness. For the purposes of the foregoing, pledging, placing a lien on or creating a security interest in any shares of Voting Stock of a Significant Subsidiary in order to secure then outstanding
Indebtedness of the Company or any Subsidiary shall be deemed to be the incurrence, issuance, assumption or Guarantee (as the case may be) of such Indebtedness. 
 The foregoing limitation shall not apply to (i) up to $10 million of Indebtedness not contemplated by clauses (ii) and (iii), (ii) Indebtedness secured by a Lien on any shares of Voting
Stock of any corporation if such Lien is made or granted prior to or at the time such corporation becomes a Significant Subsidiary, (iii) Liens securing Indebtedness of a Significant Subsidiary to the Company or another Significant Subsidiary
or (iv) the extension, renewal or replacement (or successive extensions, renewals or replacements), in whole or in part, of any Lien referred to in the foregoing clauses (ii) and (iii) but only if the principal amount of Indebtedness
secured by the Liens immediately prior to the extension, renewal or replacement is not increased and the Lien is not extended to other property. 

 Section 2.07. The Company will not, and will not permit any Subsidiary to, sell, transfer or
otherwise dispose of any shares of Capital Stock of any Significant Subsidiary (or of any Subsidiary having direct or indirect control of any Significant Subsidiary) except for, subject to the covenant relating to mergers and sales of assets
described in Section 5.1, (i) a sale, transfer or other disposition of any Capital Stock of any Significant Subsidiary (or of any Subsidiary having direct or indirect control of any Significant Subsidiary) to a Wholly Owned Subsidiary of
the Company or (ii) a sale, transfer or other disposition for at least fair value (as determined by the Board of Directors acting in good faith) of any of the Capital Stock of any Significant Subsidiary (or of any Subsidiary having direct or
indirect control of any Significant Subsidiary) held by the Company and its Subsidiaries, and in either such case, after giving effect to the use of proceeds therefrom, the Company and its Subsidiaries, considered as a whole, would continue to be
principally engaged in the business the Company and its Subsidiaries conduct as of September 17, 2012. 
 Section 2.08. The Company
may omit in any particular instance to comply with any term, provision or condition set forth in Sections 2.06 or 2.07 of this First Supplemental Indenture if, before the time for such compliance the Holders of at least a majority (or such greater
amount as may be specified in any such term, provision or condition) in Principal amount of the outstanding Securities shall, by the act of such Holders, either waive such compliance in such instance or generally waive compliance with such term,
provision or condition, but no such waiver shall extend to or affect such term, provision or condition except to the extent so expressly waived, and, until such waiver shall become effective, the obligations of the Company and the duties of the
Trustee in respect of any such term, provision or condition shall remain in full force and effect. 
 Article Three

 Redemption of the 5.000% Senior Notes 
 Section 3.01. Subject to the terms of Article Three of the Indenture, the Company shall have the right to redeem the 5.000% Senior Notes, in whole, at any time, or in part, from time to time,
at a redemption price (the “Redemption Price”) equal to the greater of (i) 100% of the principal amount of the 5.000% Senior Notes to be redeemed and (ii) the sum of the present values of the remaining scheduled payments
of principal and interest on the 5.000% Senior Notes to be redeemed (not including any portion of such payments of interest accrued to the date of redemption) discounted to the date of redemption on a semi-annual basis (assuming a 360-day year
consisting of twelve 30-day months) at the Adjusted Treasury Rate plus 50 basis points; plus, in each case, any accrued and unpaid interest thereon to the date of such redemption. If the 5.000% Senior Notes are only partially redeemed pursuant to
this Section 3.01, the 5.000% Senior Notes will be redeemed pro rata by the Trustee. The Company may not redeem the 5.000% Senior Notes in part unless all accrued and unpaid interest has been paid in full on all outstanding 5.000% Senior Notes
for all interest periods terminating on or prior to the date of redemption. 
 Notwithstanding Section 3.2 of the Indenture, the notice of
redemption with respect to the foregoing redemption need not set forth the Redemption Price but only the manner of calculation thereof. The Company shall notify the Trustee of the Redemption Price with respect to the foregoing redemption promptly
after the calculation thereof. The Trustee shall not be responsible for calculating said Redemption Price. 
 Article Four

 Form of 5.000% Senior Notes 
 The 5.000% Senior Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit A attached hereto. 

Article Five 
 Original Issue of 5.000% Senior Notes 
 5.000% Senior Notes in the aggregate principal
amount of $275,000,000 may, upon execution of this First Supplemental Indenture, or from time to time thereafter, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall thereupon authenticate and deliver
such Notes to or upon the written order of the Company, signed by its Chairman, Chief Executive Officer or President and its Treasurer or an Assistant Treasurer, Controller or Assistant Controller, without any further action by the Company.

 Article Six 
 Miscellaneous Provisions 
 Section 6.01. The Indenture, as supplemented by this
First Supplemental Indenture, is in all respects ratified and confirmed, and this First Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided and shall be read, taken and construed
as one and the same instrument. 

 Section 6.02. The recitals herein contained are made by the Company and not by the Trustee, and
the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this First Supplemental Indenture. 
 Section 6.03. This First Supplemental Indenture shall be governed by and construed in accordance with the laws of the State of New York applicable to agreements made and performed in said
state. 
 Section 6.04. This First Supplemental Indenture may be executed in any number of counterparts, each of which shall be an
original; but such counterparts shall together constitute but one and the same instrument. 

 IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be duly
executed on the date or dates indicated in the acknowledgments and as of the day and year first above written. 
  

			
	INFINITY PROPERTY AND CASUALTY CORPORATION
		
	By:	 	/s/ Samuel J. Simon
		 	  

	Name:	 	Samuel J. Simon
	Title:	 	Executive Vice President, General Counsel and Assistant Secretary
		
	Attest:	 	
	
	/s/ James H. Romaker
	Name:	 	James H. Romaker
	Title:	 	Associate General Counsel and Secretary
	
	 U.S. BANK NATIONAL ASSOCIATION
 as Trustee

		
	By:	 	/s/ Robert T. Jones
		 	  

	Name:	 	Robert T. Jones
	Title:	 	Vice President

 Signature Page to First Supplemental Indenture 

 Exhibit A 
 (FORM OF FACE OF NOTE) 
 THIS NOTE IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE
HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITORY OR A NOMINEE OF A DEPOSITORY. THIS NOTE IS EXCHANGEABLE FOR NOTES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES
DESCRIBED IN SECTION 2.2 OF THE INDENTURE, AND NO TRANSFER OF THIS NOTE (OTHER THAN A TRANSFER OF THIS NOTE AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY OR BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE
DEPOSITORY) MAY BE REGISTERED EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN SECTION 2.2 OF THE INDENTURE. 
 UNLESS THIS NOTE IS PRESENTED BY
AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, ANY TRANSFER, PLEDGE OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
  

			
	No.[         ]	  	$                

 CUSIP No. [            ] 

ISIN No. [            ] 

 INFINITY PROPERTY AND CASUALTY CORPORATION 

5.000% Senior Note due 2022 
 INFINITY PROPERTY AND CASUALTY CORPORATION, a corporation duly organized and existing under the laws of the State of Ohio (herein referred to as the “Company”, which term includes any successor
corporation under the Indenture), for value received, hereby promises to pay to Cede & Co., or registered assigns, the principal sum of Two Hundred Seventy-Five Million U.S. Dollars ($275,000,000), on September 19, 2022 (the “Stated
Maturity”), and to pay interest on such principal sum from and including September 17, 2012 or from the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, payable semi-annually in arrears
on March 19 and September 19 of each year (each such date, an “Interest Payment Date”), commencing on March 19, 2013, at the rate of 5.000% per annum, until the principal hereof shall have become due and payable, and on any overdue
principal and premium, if any, and (to the extent that payment of such interest is enforceable under applicable law) on any overdue installment of interest at the same rate per annum. The amount of interest payable on any Interest Payment Date shall
be computed on the basis of a 360-day year of twelve 30-day months and, for any period shorter than a full calendar month, on the basis of the actual number of days elapsed in such period. In the event that any date on which interest is payable on
this Note is not a Business Day, then payment of interest payable on such date will be made on the next succeeding day which is a Business Day (and without any interest or other payment in respect of any such delay), except that, if such Business
Day is in the next succeeding calendar year, such payment shall be made on the immediately preceding Business Day (and without any reduction in interest or other payment in respect of any such early payment), in each case with the same force and
effect as if made on such date. The interest installment so payable, and punctually paid or duly provided for on any Interest Payment Date will, as provided in the Indenture, be paid to the person in whose name this Note (or one or more Predecessor
Securities, as defined in the Indenture) is registered at the close of business on the last day of the month preceding the month in which such Interest Payment Date occurs (each, a “Record Date”). Any such interest installment not
punctually paid or duly provided for on any Interest Payment Date shall forthwith cease to be payable to the registered holder on the relevant Record Date, and may be paid to the person in whose name this Note (or one or more Predecessor Securities)
is registered at the close of business on a special record date to be fixed by the Trustee for the payment of such defaulted interest, notice whereof shall be given to the registered holders of this series of Notes not less than 10 days prior to
such special record date, or may be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Notes may then be listed, and upon such notice as may be required by such exchange, all as
more fully provided in the Indenture hereinafter referred to. 
 Payment of the principal of and interest due at the Stated Maturity of this
Note shall be made upon surrender of this Note at the Corporate Trust Office. The principal of and interest on this Note shall be paid in such coin of currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts. Payment of interest (including interest on an Interest Payment Date) will be made, subject to such surrender where applicable, at the option of the Company, (i) by check mailed to the address of the person entitled
thereto as such address shall appear in the Security Register or (ii) by wire transfer in immediately available funds at such place and to such account at a banking institution in the United States as may be designated in writing to the Trustee
at least 15 days prior to the date for payment by this person entitled thereto. 
 The Senior Notes (as defined on the reverse hereof) will be
senior unsecured obligations of the Company and will rank equally in right of payment with all of the other senior unsecured, unguaranteed and unsubordinated indebtedness of the Company from time to time outstanding. The Senior Notes will rank
senior to any subordinated indebtedness of the Company. 
 REFERENCE IS HEREBY MADE TO THE FURTHER PROVISIONS OF THIS NOTE SET FORTH ON THE
REVERSE HEREOF, WHICH FURTHER PROVISIONS SHALL FOR ALL PURPOSES HAVE THE SAME EFFECT AS IF SET FORTH AT THIS PLACE. 
 This Note shall not be
entitled to any benefit under the Indenture hereinafter referred to, be valid or become obligatory for any purpose until the Certificate of Authentication hereon shall have been signed by or on behalf of the Trustee. 

 IN WITNESS WHEREOF, the Company has caused this Note to be executed. 

 

			
	INFINITY PROPERTY AND CASUALTY CORPORATION
		
	By:	 	
		 	  

	Name:	 	
	Title:	 	
		
	Attest:	 	
	
	 
	Name:	 	
	Title:	 	

 Certificate of Authentication 

This is one of the Notes of the series of Securities described in the within-mentioned Indenture. 

Dated: [        ], 2012 

 

			
	 U.S. BANK NATIONAL ASSOCIATION

	 as Trustee

		
	 By:
	 	  

		 	Authorized Signatory

 (Reverse) 
 5.000% Senior Note due 2022 
 (continued) 

This Note is one of a duly authorized series of senior notes of the Company (herein sometimes referred to as the “Securities”), specified in
the Indenture (as defined below), all issued or to be issued in one or more series under and pursuant to a Senior Indenture dated as of August 6, 2010 (the “Indenture”) duly executed and delivered between the Company and U.S. Bank
National Association, a national banking association, as Trustee (herein referred to as the “Trustee”), to which Indenture and all indentures supplemental thereto (including, without limitation, the First Supplemental Indenture, dated as
of September 17, 2012, between the Company and the Trustee) reference is hereby made for a description of the rights, limitations of rights, obligations, duties and immunities thereunder of the Trustee, the Company and the holders of the Securities
and the terms upon which said Securities are, and are to be, authenticated and delivered. By the terms of the Indenture, the Securities are issuable in series which may vary as to amount, date of maturity, rate of interest and in other respects as
in the Indenture provided. This Note is one of a series designated as the 5.000% Senior Notes due 2022, limited in aggregate principal amount of $275,000,000. 
 Subject to the terms of Article Three of the Indenture, the Company shall have the right to redeem the Securities of this series at the option of the Company, in whole or in part at any time and from time
to time (an “Optional Redemption”), at a redemption price equal to the greater of (i) 100% of the principal amount of the Securities of this series to be redeemed and (ii) the sum of the present values of the remaining scheduled
payments of principal and interest on the Notes to be redeemed (not including any portion of such payments of interest accrued to the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting
of twelve 30-day months) at the Adjusted Treasury Rate, plus 50 basis points; plus, in each case, any accrued and unpaid interest thereon to the date of such redemption. If the Securities of this series are only partially redeemed by the Company
pursuant to an Optional Redemption, the Securities of this series will be redeemed pro rata by the Trustee. 
 “Adjusted Treasury
Rate” means, with respect to any date of redemption, the rate per year equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its
principal amount) equal to the Comparable Treasury Price for that date of redemption. 
 “Comparable Treasury Issue” means the United
States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the Securities to be redeemed that would be used, at the time of selection and under customary financial practice, in pricing new
issues of corporate debt securities of comparable maturity to the remaining term of the 5.000% Senior Notes. 
 “Comparable Treasury
Price” means, with respect to any date of redemption, the average of the Reference Treasury Dealer Quotations for the date of redemption, after excluding the highest and lowest Reference Treasury Dealer Quotations, or if the Quotation Agent
obtains fewer than three Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations. 
 “Quotation
Agent” means Barclays Capital Inc. and Goldman, Sachs & Co., or another Reference Treasury Dealer appointed by the Company. 

“Reference Treasury Dealer” means Barclays Capital Inc. and Goldman, Sachs & Co., and their respective successors and, at the
Company’s option, other nationally recognized investment banking firms that are primary dealers of U.S. government securities in New York City. If any of the foregoing ceases to be a primary dealer of U.S. government securities in New York
City, the Company must substitute another primary dealer of U.S. government securities. 
 “Reference Treasury Dealer Quotations”
means, with respect to each Reference Treasury Dealer and any date of redemption, the average, as determined by the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its
principal amount) quoted in writing to the Quotation Agent by the Reference Treasury Dealer at 5:00 p.m., New York City time, on the third business day before the date of redemption. 
 In the event of redemption of this Security in part only, a new Security or Securities of this series for the unredeemed portion hereof will be issued in the name of the holder hereof upon the
cancellation hereof. 

 In case an Event of Default with respect to the Securities of this series shall have occurred and be
continuing, the principal of all of the Securities of this series may be declared, and upon such declaration shall become, due and payable, in the manner, with the effect and subject to the conditions provided in the Indenture. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of the Securities of this series upon compliance by the Company
with certain conditions set forth therein. 
 The Indenture permits, with certain exceptions as therein provided, the Company and the Trustee,
with the consent of the holders of not less than a majority in aggregate principal amount of the Securities of each series affected at the time Outstanding, as defined in the Indenture, to execute supplemental indentures for the purpose of adding
any provisions to, changing in any manner or eliminating any of the provisions of the Indenture or of any supplemental indenture or of modifying in any manner the rights of the holders of the Securities. The Indenture also contains provisions
permitting the holders of a majority in aggregate principal amount of the Securities of all series at the time outstanding affected thereby, on behalf of the holders of the Securities of such series, to waive any past default in the performance of
any of the covenants contained in the Indenture, or established pursuant to the Indenture with respect to such series, and its consequences, except a default in the payment of the principal of or premium, if any, or interest on any of the Securities
of such series, which default may be waived by the unanimous consent of the holders affected. Any such consent or waiver by the registered holder of this Security (unless revoked as provided in the Indenture) shall be conclusive and binding upon
such holder and upon all future holders and owners of this Security and of any Security issued in exchange herefor or in place hereof (whether by registration of transfer or otherwise), irrespective of whether or not any notation of such consent or
waiver is made upon this Security. 
 Upon an Event of Default, the Trustee or the holders of not less than 25% in principal amount of the
outstanding Securities of this series may declare the principal of all of the Securities of this series to be immediately due and payable; and upon any such declaration such principal amount of and the accrued interest on all of the Securities of
this series shall become immediately due and payable. 
 No reference herein to the Indenture and no provision of this Security or of the
Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and premium, if any, and interest on this Security at the time and place and at the rate and in the money herein prescribed.

 As provided in the Indenture and subject to certain limitations therein set forth, this Security is transferable by the registered holder
hereof on the Security Register of the Company, upon surrender of this Security for registration of transfer at the office or agency of the Company designated for such purpose in the City of St. Paul, Minnesota, accompanied by a written instrument
or instruments of transfer in form satisfactory to the Company and the Trustee duly executed by the registered holder hereof or its attorney duly authorized in writing, and thereupon one or more new Securities of authorized denominations and for the
same aggregate principal amount and series will be issued to the designated transferee or transferees. No service charge will be made for any such transfer, but the Company may require payment of a sum sufficient to cover any tax or other
governmental charge payable in relation thereto. 
 Prior to due presentment for registration of transfer of this Security, the Company, the
Trustee, any paying agent and any Security Registrar may deem and treat the registered holder hereof as the absolute owner hereof (whether or not this Security shall be overdue and notwithstanding any notice of ownership or writing hereon made by
anyone other than the Security Registrar) for the purpose of receiving payment of or on account of the principal hereof and premium, if any, and interest due hereon and for all other purposes, and neither the Company nor the Trustee nor any paying
agent nor any Security Registrar shall be affected by any notice to the contrary. 
 No recourse shall be had for the payment of the principal
of or the interest on this Security, or for any claim based hereon, or otherwise in respect hereof, or based on or in respect of the Indenture, against any incorporator, stockholder, officer or director, past, present or future, as such, of the
Company or of any predecessor or successor corporation, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise, all such liability being, by the acceptance hereof and as part of
the consideration for the issuance hereof, expressly waived and released. 
 [If this Note is to be issued as a Registered Global Security,
insert: This Registered Global Security is exchangeable for Securities in certificated form only under certain limited circumstances set forth in the Indenture. The Securities of this series are issuable in registered form without coupons in
denominations of $2,000 and integral multiples of $1,000 in excess 

 
thereof. As provided in the Indenture and subject to certain limitations herein and therein set forth, Securities of this series so issued are exchangeable for a like aggregate principal amount
of Securities of this series of a different authorized denomination, as requested by the holder surrendering the same. 
 All terms used in this
Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 
 This Security shall be governed by and
construed in accordance with the laws of the State of New York applicable to agreements made and performed in said state.Tender and Support Agreement

 Exhibit 10.1 
 EXECUTION COPY 
 TENDER AND SUPPORT
AGREEMENT 
 This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of
September 15, 2012, is by and among BGI-Shenzhen, a company organized under the laws of the People’s Republic of China (“Parent”), Beta Acquisition Corporation, a Delaware corporation and a wholly owned Subsidiary of
Parent (the “Purchaser”), and the Persons set forth on Schedule A hereto (each, a “Stockholder”). 
 WHEREAS, as of the date hereof, each Stockholder is the holder of the number of shares of common stock, par value $0.001 per share (“Common Stock”), of Complete Genomics, Inc., a
Delaware corporation (the “Company”), set forth opposite such Stockholder’s name on Schedule A (all such shares set forth on Schedule A, together with any shares of Common Stock of the Company that are hereafter
issued to or otherwise acquired or owned by any Stockholder prior to the termination of this Agreement being referred to herein as the “Subject Shares”); 

WHEREAS, Parent, the Purchaser and the Company propose to enter into an Agreement and Plan of Merger, dated as of
the date hereof and a true and correct copy of which has been delivered to each Stockholder (the “Merger Agreement”), which provides, among other things, for the Purchaser to commence a tender offer for all of the issued and
outstanding Common Stock of the Company (the “Offer”) and the merger of the Purchaser with and into the Company, with the Company continuing as the surviving corporation (the “Merger”), upon the terms and subject to
the conditions set forth in the Merger Agreement (capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to such terms in the Merger Agreement); and 

WHEREAS, as a condition to their willingness to enter into the Merger Agreement, Parent and the Purchaser have
required that each Stockholder, and as an inducement and in consideration therefor, each Stockholder (in such Stockholder’s capacity as a holder of the Subject Shares) has agreed to, enter into this Agreement. 

NOW, THEREFORE, in consideration of the foregoing and the respective representations, warranties, covenants and
agreements set forth below and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, do hereby agree as follows: 

ARTICLE I 

AGREEMENT TO TENDER 
 1.1. Agreement to Tender. Unless this Agreement shall have been terminated in accordance with its terms, each Stockholder shall validly tender or cause to be tendered in the Offer all
of such Stockholder’s Subject Shares pursuant to and in accordance with the terms of the Offer. Without limiting the generality of the foregoing, as promptly as practicable after receipt by such Stockholder of all documents or instruments
required to be delivered pursuant to the terms of the Offer (but in any event no later than ten (10) Business Days after the commencement of the Offer), each Stockholder shall (i) deliver to the Paying Agent (A) a letter of
transmittal with respect to such Stockholder’s Subject Shares complying with the terms of the Offer, (B) a Certificate or Certificates representing such Subject Shares or an “agent’s message” (or such other evidence, if any,
of transfer as the Paying 

 
Agent may reasonably request) in the case of a Book-Entry Share of any uncertificated Subject Shares, and (C) all other documents or instruments required to be delivered pursuant to the
terms of the Offer, or (ii) instruct and otherwise cause such Stockholder’s broker and cause such other Person that is the holder of record of any Subject Shares beneficially owned by such Stockholder to tender such Subject Shares pursuant
to and in accordance with clause (i) of this Section 1.1 and the terms of the Offer. Each Stockholder agrees that, once such Stockholder’s Subject Shares are tendered, such Stockholder will not withdraw any of such Subject Shares from
the Offer, unless and until (A) the Offer shall have been terminated by the Purchaser in accordance with the terms of the Merger Agreement or (B) this Agreement shall have been terminated in accordance with its terms; provided,
however, that (x) a Stockholder shall not be required, for purposes of this Agreement, to exercise any unexercised Company Option held by such Stockholder and (y) a Stockholder shall not have any obligation under this
Section 1.1 to tender any Subject Shares into the Offer to extent such shares constitute Company RSUs or if that tender could cause such Stockholder to incur liability under Section 16(b) of the Exchange Act. 

Notwithstanding anything to the contrary contained herein, the obligations of each Stockholder under this Agreement are
several and not joint with any other Stockholder. 
 ARTICLE II 

REPRESENTATIONS AND WARRANTIES OF THE STOCKHOLDERS 

Each Stockholder represents and warrants to Parent and the Purchaser as to such Stockholder, severally and not jointly,
that: 
 2.1. Authorization; Binding Agreement. Each Stockholder has full legal capacity,
power and authority to execute and deliver this Agreement, to perform his or its obligations under this Agreement and to consummate the transactions contemplated by this Agreement. This Agreement has been duly and validly executed and delivered by
such Stockholder and, except for withdrawal or similar rights that may be provided by federal or state securities Laws, constitutes a valid and binding agreement of such Stockholder, enforceable against him in accordance with its terms, subject to
the effects of bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and other similar laws relating to or affecting creditors’ rights generally and general equitable principles (whether considered in a proceeding in equity
or at law). 
 2.2. Non-Contravention. The execution and delivery of this Agreement by such
Stockholder does not, and the performance by such Stockholder of such Stockholder’s obligations hereunder and the consummation by such Stockholder of the transactions contemplated hereby will not (i) violate any Laws applicable to such
Stockholder or such Stockholder’s Subject Shares or which may in any material respect delay, impair or prevent the performance by Stockholder of its obligations under this Agreement, (ii) except as may be required by federal or state
securities Law, require any consent, approval, order, authorization or other action by, or filing with or notice to, any Person (including any Governmental Authority) under, constitute a default (with or without the giving of notice or the lapse of
time or both) under, or give rise to any right of termination, cancellation or acceleration under any contract, agreement or other instrument binding on such Stockholder, or (iii) if such Stockholder is not an individual, violate any provision
of such Stockholder’s organizational documents. 
 2.3. Ownership of Subject Shares; Total
Shares. Such Stockholder is the record or beneficial owner (as defined in Rule 13d-3 under the Exchange Act) of such Stockholder’s Subject 

  
 2 

 
Shares and has good and marketable title to such Subject Shares free and clear of any Encumbrance (including any restriction on the right to vote or otherwise transfer such Subject Shares),
except as (i) provided hereunder, (ii) pursuant to any applicable restrictions on transfer under the Securities Act, and (iii) subject to any risk of forfeiture with respect to any shares of Common Stock granted to such Stockholder
under an employee benefit plan of the Company. The Subject Shares listed on Schedule A opposite such Stockholder’s name constitute all of the shares of Common Stock of the Company owned of record, by such Stockholder as of the date
hereof. Except pursuant to this Agreement, no Person has any contractual right or obligation to purchase or otherwise acquire any of such Stockholder’s Subject Shares. 

2.4. Voting Power. Except as set forth on Schedule A, such Stockholder has sole and full voting
power with respect to such Stockholder’s Subject Shares, and sole and full power of disposition, and full power to issue instructions with respect to the matters set forth herein, in each case with respect to all of such Stockholder’s
Subject Shares. None of such Stockholder’s Subject Shares are subject to any proxy, voting trust or other agreement or arrangement with respect to the voting of such Subject Shares, except as provided hereunder. 

2.5 Absence of Litigation. With respect to such Stockholder, as of the date hereof, there is no action,
suit, investigation or proceeding pending against, or, to the knowledge of such Stockholder, threatened in writing against, such Stockholder or with respect to the Subject Shares that could reasonably be expected to prevent, delay or impair, the
ability of such Stockholder to perform its obligations hereunder or to consummate the transactions contemplated hereby. 
 2.6 No Brokers. No broker, investment banker, financial advisor or other Person is entitled to any broker’s, finder’s, financial advisor’s or other similar fee or commission
in connection with the Merger and the other transactions contemplated by the Merger Agreement based upon arrangements made by or at the direction of the Stockholder. 
 ARTICLE III 
 REPRESENTATIONS AND WARRANTIES OF PARENT AND THE PURCHASER

 Each of Parent and the Purchaser represent and warrant to the Stockholders, jointly and severally, that:

 3.1. Organization; Authorization. Parent and the Purchaser are each duly organized, validly
existing and in good standing under the laws of its respective jurisdiction of its organization. The consummation of the transactions contemplated hereby are within each of Parent’s and the Purchaser’s corporate powers and have been duly
authorized by all necessary corporate actions on the part of Parent and the Purchaser. Parent and the Purchaser have full power and authority to execute, deliver and perform this Agreement and the Merger Agreement, subject to its terms. 

3.2. Binding Agreement. This Agreement and the Merger Agreement have been duly authorized, executed
and delivered by each of Parent and the Purchaser, and constitute valid and binding obligation of Parent and the Purchaser enforceable against Parent and the Purchaser in accordance with their respective terms, subject to the effects of bankruptcy,
insolvency, fraudulent conveyance, reorganization, moratorium and other similar laws relating to or affecting creditors’ rights generally and general equitable principles (whether considered in a proceeding in equity or at law). 

  
 3 

 ARTICLE IV 
 ADDITIONAL COVENANTS OF THE STOCKHOLDERS 
 Each Stockholder
hereby covenants and agrees, severally and not jointly, that: 
 4.1. Voting of Subject
Shares. At every meeting of the Company’s stockholders called, and at every adjournment or postponement thereof, and at any action by written consent of the Company’s stockholders, such Stockholder shall, or shall cause the holder
of record on any applicable record date to, vote or consent, as the case may be, such Stockholder’s Subject Shares (to the extent that any of the Subject Shares are not purchased in the Offer) (i) in favor of (A) adoption of the
Merger Agreement and (B) approval of any proposal to adjourn or postpone the meeting to a later date, if there are not sufficient votes for the adoption of the Merger Agreement on the date on which such meeting is held; (ii) against
(A) any Acquisition Proposal, (B) any action, proposal, transaction or agreement that would reasonably be expected to result in the failure of any Offer Condition to be satisfied, (C) any merger agreement or merger (other than the
Merger Agreement and the Merger), consolidation, scheme of arrangement, combination, sale of assets, reorganization, recapitalization, dissolution, liquidation or winding up of or by the Company, (D) any amendment of the Company Certificate or
the Company Bylaws, or (E) other proposal or transaction involving the Company or any Company Subsidiary, which proposal or transaction would in any manner impede, delay, frustrate, prevent or nullify any provision of the Merger Agreement, the
Merger or any other transaction contemplated by the Merger Agreement or change in any manner the voting rights of any class of the Company’s capital stock; and (iii) in favor of any other matter necessary for consummation of the
transactions contemplated by the Merger Agreement, which is considered at any such meeting of the Company’s stockholders. 
 4.2. No Inconsistent Arrangements. Except as provided hereunder or under the Merger Agreement, such Stockholder shall not, directly or indirectly, (i) create or permit to exist any
Encumbrance other than restrictions imposed by applicable Law or pursuant to this Agreement on any such Subject Shares, (ii) transfer (including, by tendering into a tender or exchange offer), sell, assign, pledge, gift or otherwise dispose of
(including, by gift, merger or operation of law (collectively, “Transfer”)) or enter into any contract, option or other arrangement with respect to any Transfer of such Subject Shares or any Transfer of any interest therein,
(iii) grant or permit the grant of any proxy, power of attorney or other authorization in or with respect to such Subject Shares, (iv) deposit or permit the deposit of such Subject Shares into a voting trust or enter into a voting
agreement or arrangement with respect to such Subject Shares, (v) take or permit any other action that would in any way restrict, limit, prevent or interfere with the performance of such Stockholder’s obligations hereunder or the
transactions contemplated hereby or otherwise make any representation or warranty of such Stockholder herein untrue or incorrect, or (vi) commit or agree to take any of the foregoing actions. Notwithstanding the foregoing, such Stockholder may
make (a) Transfers of Subject Shares by will, operation of law, Transfers for estate planning purposes or Transfers for charitable purposes or as charitable gifts or donations, in which case the Subject Shares shall continue to be bound by this
Agreement and provided that each transferee agrees, prior to such Transfer, in writing with Parent in an instrument reasonably satisfactory in form and substance to Parent to be bound by the terms and conditions of this Agreement and (b) as
Transfers of Subject Shares as Parent may otherwise agree in writing in its sole discretion. 

4.3. No Exercise of Appraisal Rights. Such Stockholder agrees not to exercise any appraisal rights or
dissenter’s rights in respect of such Stockholder’s Subject Shares that may arise with respect to the Merger. 

  
 4 

 4.4. Documentation and Information. Such Stockholder
shall permit and hereby authorizes Parent and the Purchaser to publish and disclose in all documents and schedules filed with the SEC, and any press release or other disclosure document that Parent or the Purchaser reasonably determines to be
necessary in connection with the Offer, the Merger and any transactions contemplated by the Merger Agreement, such Stockholder’s identity and ownership of the Subject Shares and the nature of such Stockholder’s commitments and obligations
under this Agreement (provided that any such publication, disclosure, release or disclosure with respect to any matter related to such Stockholder shall be made with respect to all Stockholders). 

4.5. Irrevocable Proxy. Such Stockholder hereby revokes (or agrees to cause to be revoked) any proxies
that such Stockholder has heretofore granted with respect to the Subject Shares. Such Stockholder hereby irrevocably appoints Parent and any designee of Parent as attorney-in-fact and proxy for and on behalf of such Stockholder, for and in the name,
place and stead of such Stockholder, to: (a) attend any and all meetings of the Company’s stockholders, (b) vote, express consent or dissent or issue instructions to the record holder to vote such Stockholder’s Subject Shares in
accordance with the provisions of Section 4.1 at any and all meetings of the Company’s stockholders or in connection with any action sought to be taken by written consent of the Company’s stockholders without a meeting and
(c) grant or withhold, or issue instructions to the record holder to grant or withhold, consistent with the provisions of Section 4.1, all written consents with respect to the Subject Shares at any and all meetings of the Company’s
stockholders or in connection with any action sought to be taken by written consent without a meeting, provided, however, the foregoing shall only be effective if (x) such Stockholder fails to tender such Stockholder’s Subject Shares
pursuant to Section 1.1 above or (y) a Tail Event occurs. Parent agrees not to exercise the proxy granted herein for any purpose other than the purposes described in this Agreement. The foregoing proxy shall be deemed to be a proxy coupled
with an interest, is irrevocable in accordance with the provisions of Section 212(e) of the DGCL (and, without limiting the foregoing, as such shall survive and not be affected by the death, incapacity, mental illness or insanity of such
Stockholder, as applicable) until the later to occur of the termination of the Merger Agreement or the termination of such Stockholder’s obligations under this Section 4.5 pursuant to Section 5.2. Such Stockholder authorizes such
attorney and proxy to substitute any other Person to act hereunder, to revoke any substitution and to file this proxy and any substitution or revocation with the secretary of the Company. Such Stockholder hereby affirms that the proxy set forth in
this Section 4.5 is given in connection with and granted in consideration of and as an inducement to Parent and the Purchaser to enter into the Merger Agreement and that such proxy is given to secure the obligations of the Stockholder under
Section 4.1. Upon delivery of written request to do so by Parent, each such Stockholder shall as promptly as practicable execute and deliver to Parent a separate written instrument or proxy that embodies the terms of the irrevocable proxy set
forth in this Section 4.5. 
 4.6. No Solicitation. Such Stockholder shall not directly
or indirectly: (i) solicit, initiate, seek or knowingly encourage or facilitate any Acquisition Proposal or take any action to solicit, initiate, seek or knowingly encourage or knowingly facilitate any inquiry, expression of interest, proposal
or offer that constitutes or could reasonably be expected to lead to an Acquisition Proposal, (ii) enter into, participate or engage in, maintain or continue any discussions or negotiations relating to, any Acquisition Proposal with any Person
other than Parent, the Purchaser or the Company (including for such purpose any officer or director of the Company), (iii) approve, endorse, recommend, execute or enter into any agreement, letter of intent or Contract with respect to any
Acquisition Proposal or otherwise relating to or that is intended to or would reasonably be expected to lead to any Acquisition Proposal (other than an Acceptable Confidentiality Agreement) or enter into any agreement,

  
 5 

 
arrangement or understanding requiring the Company to abandon, terminate or fail to consummate the Merger or any other transactions contemplated by this Agreement, (v) submit any Acquisition
Proposal or any matter related thereto to the vote of the stockholders of the Company, or (vi) agree to do any of the foregoing. Such Stockholder shall immediately cease any and all existing activities, discussions or negotiations with any
Persons conducted by such Stockholder (other than the Company and including for such purpose any officer or director of the Company) on or prior to the date of this Agreement with respect to any Acquisition Proposal. 

ARTICLE V 

MISCELLANEOUS 
 5.1. Notices. All notices, requests and other communications to any party hereunder shall be in writing (including facsimile transmission) and shall be given, (i) if to Parent or
the Purchaser, in accordance with the provisions of the Merger Agreement and (ii) if to a Stockholder, to such Stockholder’s address or facsimile number set forth on a signature page hereto, or to such other address or facsimile number as
such party may hereafter specify for the purpose by notice to each other party hereto. Each Stockholder shall promptly notify Parent in writing upon acquiring any additional shares of Company Common Stock or any other additional voting securities of
the Company. 
 5.2. Termination. This Agreement shall terminate automatically, without any
notice or other action by any Person, upon the earlier of (i) the termination of the Merger Agreement in accordance with its terms, (ii) the Effective Time, or (iii) any change in the form (other than to add new additional
consideration) or decrease in the amount of consideration payable in the Offer; provided, however, that in the event the Merger Agreement is terminated pursuant to Sections 7.1(e) or 7.1(h) or is otherwise terminated pursuant to
Section 7.1 in circumstances where an Acquisition Proposal shall have been made known to the Company or an Acquisition Proposal shall have been made to the stockholders of the Company generally or any Person shall have publicly announced an
intention (whether or not conditional) to make an Acquisition Proposal, the obligations of each Stockholder under Sections 4.1, 4.2 and 4.5 shall continue for 180 calendar days following such termination (any of the foregoing, a “Tail
Event”). Upon termination of this Agreement, no party shall have any further obligations or liabilities under this Agreement; provided, however, that (x) nothing set forth in this Section 5.2 shall relieve any party
from liability for any willful breach of this Agreement prior to termination hereof, and (y) the provisions of this Article V shall survive any termination of this Agreement. 

5.3. Amendments and Waivers. Any provision of this Agreement may be amended or waived if such
amendment or waiver is in writing and is signed, in the case of an amendment, by each party to this Agreement or, in the case of a waiver, by each party against whom the waiver is to be effective. No failure or delay by any party in exercising any
right, power or privilege hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power or privilege. 

5.4. Expenses. All costs and expenses incurred in connection with this Agreement shall be paid by the
party incurring such cost or expense. 
 5.5. Binding Effect; Benefit; Assignment. The
provisions of this Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their respective successors and assigns. No provision of this Agreement is intended to confer any rights, benefits, remedies, obligations or

  
 6 

 
liabilities hereunder upon any person other than the parties hereto and their respective successors and assigns. No party may assign, delegate or otherwise transfer any of its rights or
obligations under this Agreement without the consent of each other party hereto. 
 5.6. Governing
Law; Venue. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware without regard to its rules of conflict of laws. Each of Parent and the Purchaser and each Stockholder hereby irrevocably and
unconditionally consents to submit to the exclusive jurisdiction of the courts of Delaware Court of Chancery, or if no such state court has proper jurisdiction, then the Federal court of the U.S. located in the State of Delaware, and appellate
courts therefrom, (collectively, the “Delaware Courts”) for any litigation arising out of or relating to this Agreement and the transactions contemplated hereby (and agrees not to commence any litigation relating thereto except in
such courts), waives any objection to the laying of venue of any such litigation in the Delaware Courts and agrees not to plead or claim in any Delaware Court that such litigation brought therein has been brought in any inconvenient forum. Each of
the parties hereto agrees (i) to the extent such party is not otherwise subject to service of process in the State of Delaware, to appoint and maintain an agent in the State of Delaware as such party’s agent for acceptance of legal process
and (ii) that service of process may also be made on such party by prepaid certified mail with a proof of mailing receipt validated by United States Postal Service constituting evidence of valid service. Service made pursuant to (i) or
(ii) above shall have the same legal force and effect as if served upon such party personally within the State of Delaware. EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING
OUT OF OR RELATED TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT. 

5.7. Counterparts. This Agreement may be executed in one or more counterparts and delivered by means
of facsimile or other means of electronic transmission (such as .pdf format), and by the different parties hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall
constitute one and the same agreement. 
 5.8. Entire Agreement. This Agreement constitutes
the entire agreement between the parties with respect to the subject matter of this Agreement and supersedes all prior agreements and understandings, both oral and written, between the parties with respect to its subject matter and there are no
other agreements between any Stockholder, on one hand, and Parent, on the other hand with respect to the subject matter hereof. 
 5.9. Severability. If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by any rule of Law or public policy, all other conditions and
provisions of this Agreement shall nevertheless remain in full force and effect. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify
this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that transactions contemplated hereby are fulfilled to the extent possible. 

5.10. Specific Performance. The parties hereto agree that each of Parent and the Purchaser would be
irreparably damaged in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached by any Stockholder. It is accordingly agreed that Parent and the Purchaser shall be
entitled to an injunction or injunctions to prevent breaches of this Agreement by any Stockholder and to enforce specifically the terms and 

  
 7 

 
provisions hereof in any Delaware Court, this being in addition to any other remedy to which they are entitled at Law or in equity. 

5.11. Headings. The headings contained in this Agreement are for reference purposes only and shall not
affect in any way the meaning or interpretation of this Agreement. 
 5.12. No Presumption.
This Agreement shall be construed without regard to any presumption or rule requiring construction or interpretation against the party drafting or causing any instrument to be drafted. 

5.13. Further Assurances. Parent, the Purchaser and each Stockholder will execute and deliver, or
cause to be executed and delivered, all further documents and instruments and use their respective reasonable best efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things necessary, proper or advisable under
applicable Laws and regulations, to perform their respective obligations as expressly set forth under this Agreement. 
 5.14. Interpretation. Unless the context otherwise requires, as used in this Agreement: (i) “or” is not exclusive; (ii) “including” and its variants
mean “including, without limitation” and its variants; (iii) words defined in the singular have the parallel meaning in the plural and vice versa; (iv) words of one gender shall be construed to apply to each gender; and
(v) the terms “Article,” “Section” and “Schedule” refer to the specified Article, Section or Schedule of or to this Agreement. 

5.15 Capacity as Stockholder. Each Stockholder signs this Agreement solely in such Stockholder’s
capacity as a Stockholder of the Company, and not in such Stockholder’s capacity as a director, officer or employee of the Company or any of its Subsidiaries or in such Stockholder’s capacity as a trustee or fiduciary of any employee
benefit plan or trust, or in any other capacity whatsoever. 
 5.16 No Agreement Until
Executed. Irrespective of negotiations among the parties or the exchanging of drafts of this Agreement, this Agreement shall not constitute or be deemed to evidence a contract, agreement, arrangement or understanding between the parties
hereto unless and until (a) the Merger Agreement is executed by all parties thereto, and (b) this Agreement is executed by all parties hereto. 
 [SIGNATURE PAGE(S) FOLLOWS] 

  
 8 

 The parties are executing this Agreement on the date set forth in the
introductory clause. 
  

			
	 BGI-Shenzhen

		
	 By:
	 	 /s/ Wang Jun

		 	  

		 	 Name: Wang Jun

		 	 Title:

  

			
	 Beta Acquisition Corporation

		
	 By:
	 	 /s/ Yin Ye

		 	  

		 	 Name: Yin Ye

		 	 Title: COO

 [Signature Page to Tender and Support Agreement] 

 
					
	 STOCKHOLDERS

		
	 By:
	 	 /s/ Clifford A. Reid

		 	 Name:
	 	 Clifford A. Reid

  

					
		
	 By:
	 	 /s/ Ajay Bansal

		 	 Name:
	 	 Ajay Bansal

  

					
		
	 By:
	 	 /s/ Radoje T. Drmanac

		 	 Name:
	 	 Radoje T. Drmanac

  

					
		
	 By:
	 	 /s/ A. W. Homan

		 	 Name:
	 	 A. W. Homan

  

					
		
	 By:
	 	 /s/ Keith Raffel

		 	 Name:
	 	 Keith Raffel

  

					
		
	 By:
	 	 /s/ C. Thomas Caskey

		 	 Name:
	 	 C. Thomas Caskey

  

					
		
	 By:
	 	 /s/ Lewis J. Shuster

		 	 Name:
	 	 Lewis J. Shuster

 [Signature Page to Tender and Support Agreement] 

 
					
		
	 By:
	 	 /s/ Charles P. Waite, Jr.

		 	 Name:
	 	 Charles P. Waite, Jr.

  

					
		
	 By:
	 	 /s/ Robert T. Wall

		 	 Name:
	 	 Robert T. Wall

 [Signature Page to Tender and Support Agreement] 

 
							
	 ESSEX WOODLANDS HEALTH
VENTURES FUND VIII, L.P.

		
	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, L.P.

		 	 Its General Partner

			
		 	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, LLC

		 		 	 Its General Partner

				
		 		 	 By:
	 	 /s/ Jeff Himawan

		 		 	 Name:
	 	 Jeff Himawan

		 		 	 Title:
	 	 Manager

  

							
	 ESSEX WOODLANDS HEALTH
VENTURES FUND VIII-A, L.P.

		
	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, L.P.

		 	 Its General Partner

			
		 	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, LLC

		 		 	 Its General Partner

				
		 		 	 By:
	 	 /s/ Jeff Himawan

		 		 	 Name:
	 	 Jeff Himawan

		 		 	 Title:
	 	 Manager

  

							
	 ESSEX WOODLANDS HEALTH
VENTURES FUND VIII-B, L.P.

		
	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, L.P.

		 	 Its General Partner

			
		 	 By:
	 	 ESSEX WOODLANDS HEALTH
VENTURES VIII, LLC

		 		 	 Its General Partner

				
		 		 	 By:
	 	 /s/ Jeff Himawan

		 		 	 Name:
	 	 Jeff Himawan

		 		 	 Title:
	 	 Manager

 [Signature Page to Tender and Support Agreement] 

 
					
	 OVP Venture Partners VI, L.P.

			
	 By:
	 		 	
	 Its:
	 		 	
		
	 By:
	 	 /s/ Charles P. Waite, Jr.

		 	 Name:
	 	 Charles P. Waite, Jr.

		 	 Title:
	 	 Manager

  

					
	 OVP VI Entrepreneurs Fund, L.P.

			
	 By:
	 		 	
	 Its:
	 		 	
		
	 By:
	 	 /s/ Charles P. Waite, Jr.

		 	 Name:
	 	 Charles P. Waite, Jr.

		 	 Title:
	 	 Manager

  

					
	 OVMC VI, LLC

			
		 		 	
		 		 	
		
	 By:
	 	 /s/ Charles P. Waite, Jr.

		 	 Name:
	 	 Charles P. Waite, Jr.

		 	 Title:
	 	 Manager

 [Signature Page to Tender and Support Agreement] 

 Schedule A 

 

					
	 Name of Stockholder
	  	No. Shares	 
	 Clifford A. Reid
	  	 	310,200	  
		
	 Ajay Bansal
	  	 	1,696	  
		
	 Radoje T. Drmanac
	  	 	131,999	  
		
	 A. W. Homan
	  	 	0	  
		
	 Keith Raffel
	  	 	10,000	  
		
	 C. Thomas Caskey
	  	 	5,984	  
		
	 Lewis J. Shuster
	  	 	833	  
		
	 Charles P. Waite, Jr.
	  	 	1,666	  
		
	 Robert T. Wall
	  	 	50,833	  
		
	 Essex Woodlands Health and affiliates
	  	 	4,156,269	  
		
	 OVP Venture Partners and affiliates
	  	 	1,424,629

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00208-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00208-of-00352.parquet"}]]