Document:

EX-10.7

 Exhibit 10.7 

DIRECTOR AND OFFICER INDEMNIFICATION AGREEMENT (the “Agreement”) dated
[                ], between Repare Therapeutics Inc. (the “Corporation”), a corporation continued under the Business
Corporations Act (Quebec) and [                ] (the “Indemnified Party” and, together with the Corporation, the
“Parties”). 
 RECITALS: 
  

	 	(a)	 Each of the Business Corporations Act (Quebec) and the Corporation’s
by-laws requires the Corporation to indemnify its current and former directors and officers and its other mandataries and persons who act or acted at the Corporation’s request as directors or officers of
another Group (as defined below) against all costs, charges and expenses reasonably incurred in the exercise of their functions, including an amount paid to settle an action or satisfy a judgment, or arising from any investigative or other
proceeding in which the person is involved, provided that certain conditions are fulfilled. 

  

	 	(b)	 On the basis of the terms and conditions set out in this Agreement, the Indemnified Party has consented to act
as a director and/or officer of the Corporation, or, at the Corporation’s request, as a director and/or officer of, or in a similar capacity for, any other legal person, group of persons, or group of properties, including an organization, joint
venture or trust (each a “Group”). 

  

	 	(c)	 The Corporation considers it desirable and in the best interests of the Corporation to enter into this
Agreement to set out the circumstances and manner in which the Indemnified Party may be indemnified in respect of certain liabilities or expenses which the Indemnified Party may incur as a result of acting as a director or officer of the Corporation
or any other Group. 

 In consideration of the foregoing and for other good and valuable consideration (the receipt and
sufficiency of which are hereby acknowledged), the Parties agree as follows:  
  

	1.	 Indemnity 

Subject to Section 8 of this Agreement, the Corporation agrees to indemnify and save the Indemnified Party harmless, to the fullest extent
permitted by law, against all Liabilities (as defined below). 
 “Liabilities” means all losses, liabilities, claims, damages, costs,
charges, fees or expenses which the Indemnified Party reasonably incurs, whether incurred alone or jointly with others, as a result of and/or in the exercise of the Indemnified Party’s functions as described above, including, without
limitation: 
  

	 	(a)	 an amount paid to settle an action or satisfy a judgment or arising from any investigative or other Proceeding
(as defined below); 

  

	 	(b)	 all legal and other professional fees and disbursements incurred in connection with any Proceeding or the
appeal of a judgment or decision rendered pursuant to a Proceeding; 

  

	 	(c)	 all reasonable out-of-pocket
expenses incurred by the Indemnified Party to prepare for and attend to any Proceeding, including out-of-pocket expenses for attending discoveries, trials, hearings, and
meetings; 

  

	 	(d)	 in the case where the Indemnified Party is no longer an employee of the Corporation, reasonable compensation
for all time devoted by the Indemnified Party to any Proceeding; 

  

	 	(e)	 any fines or other financial penalties imposed against the Indemnified Party in connection with any Proceeding
as a result of a conviction or reprimand under the law because of the Indemnified Party’s position as director or officer of the Corporation, or because the Indemnified Party acted as director or officer of, or in a similar capacity for, any
other Group at the request of the Corporation;  

	 	(f)	 a fine, penalty, levy or charge paid to any domestic or foreign government (federal, provincial, municipal or
otherwise) or to any regulatory authority, agency, commission or board of any domestic or foreign government, or imposed by any court, tribunal or any other law, regulation or rule-making entity having jurisdiction in the relevant circumstances
(collectively, a “Governmental Authority”), including as a result of a breach or alleged breach of any statutory duty imposed on directors or officers or of any law, statute, rule or regulation or of any provision of the articles, by-laws or any resolution of the Corporation or any other Group; 

  

	 	(g)	 an amount required to be paid to satisfy a liability arising as a result of the failure of the Corporation or
any other Group to pay wages, vacation pay and any other amounts that may be owing to employees or to make contributions that may be required to be made to any pension plan, retirement income plan or other benefit plan for employees or to remit to
any Governmental Authority payroll deductions, income taxes or other taxes, or any other amounts payable by the Corporation or any other Group; and 

  

	 	(h)	 the full amount of any income taxes that the Indemnified Party is required to pay as a consequence of receiving
any payment made by the Corporation pursuant to this Agreement, unless, in computing the Indemnified Party’s income for income tax purposes the Indemnified Party is entitled to deduct the amounts paid by the Indemnified Party on account of
Liabilities for which the Indemnified Party has been indemnified by the Corporation under this Agreement.  

“Proceeding” means any civil, criminal, administrative, investigative or other proceeding (i) in which the Indemnified Party is involved
or made a party to, or threatened to be made a party to, and (ii) which arises by reason of being or having been a director or officer of the Corporation or by reason of being or having been a director or officer of, or serving or having served
in a similar capacity for, any other Group at the request of the Corporation. 
  

	2.	 Additional Rights to Indemnification 

The indemnities in Section 1 shall also apply [(a)] in respect of offices held or functions performed by the Indemnified Party, at the
Corporation’s request, similar to those held or performed by a director or officer, for a partnership, trust, joint venture or other unincorporated entity of which the Corporation is or was a creditor or in which the Corporation has or had an
interest [and (b) in respect of any venture capital fund affiliated with the Indemnified Party that has invested in the Corporation by reason of such fund being or having been a shareholder in the Corporation but only to the extent that such
fund’s involvement in any action or Proceeding is related to the Indemnified Party’s service as a director or officer or such fund’s affiliation with the Indemnified Party]. In addition, the indemnities provided by this Agreement
shall not be deemed exclusive of any rights to which the Indemnified Party may be entitled [(i)] under the Corporation’s constating documents or the Business Corporations Act (Quebec) or any insurance policy or any contract with the
Corporation[, or (ii) in the case of any Indemnified Party affiliated with any venture capital fund, under any indemnification or insurance provided by the applicable venture capital fund or firm (in which case, the Corporation agrees that it
shall be the indemnitor of first resort and the Corporation waives and releases any and all claims against such venture capital fund or firm for contribution, subrogation or any other recovery in respect of any indemnification provided by the
Corporation under this Agreement; however if the venture capital fund or firm does make any advance or payment to the Indemnified Party in respect of any claim for which the Indemnified Party has sought indemnification from the Corporation, the
venture capital fund or firm shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of the Indemnified Party against the Corporation)]. [It is the intention of the
Corporation to constitute the Indemnified Party as a trustee for the venture capital funds referenced in this Section 2 of the covenants of the Corporation contained herein, and the Indemnified Party agrees to accept such trust and to hold and
enforce such covenants on behalf of such venture capital funds.] 

	3.	 Indemnification Procedure 

In the event the Indemnified Party is, was, or becomes a party to or witness or otherwise a participant in or are threatened to be made a party
to or witness or otherwise a participant in a Proceeding, for any reason, the Corporation shall indemnify the Indemnified Party to the fullest extent permitted by law as soon as practicable, but in any event no later than 10 days after a written
demand is presented to the Corporation, against any and all Liabilities paid or incurred (including all penalties, interest, assessments, and other charges paid or payable in connection with or in respect of such Liabilities, or amounts paid in
settlement) on account of such Proceeding. 
  

	4.	 Partial Indemnity 

If the Indemnified Party is determined to be entitled under any provision of this Agreement or any applicable law to indemnification by the
Corporation for some or a portion of the Liabilities or amounts paid in settlement of a Proceeding, but not, however, for the total amount thereof, the Corporation shall nevertheless indemnify the Indemnified Party for the portion thereof to which
the Indemnified Party is entitled. 
  

	5.	 Advance of Costs 

Subject to Sections 6 and 8 of this Agreement, the Corporation shall promptly advance monies to the Indemnified Party for the costs, fees,
advances, disbursements, charges, retainers, bonds, and expenses stemming from any of the Liabilities or arising from the Indemnified Party’s involvement or participation in any Proceeding, including, without limitation, costs, charges and
expenses incurred by the Indemnified Party in the monitoring, investigation or defense of any Proceeding; provided, however, that, the Indemnified Party shall provide the Corporation with a written affirmation of the Indemnified Party’s good
faith belief that the Indemnified Party has (i) acted with honesty and loyalty in the interest of the Corporation, or, as the case may be, in the interest of any other Group, (ii) in the case of a Proceeding that is enforced by a monetary
penalty, had reasonable grounds for believing that the Indemnified Party’s conduct was lawful and (iii) has not committed an intentional or gross fault, along with sufficient particulars of the costs, fees, advances, disbursements,
charges, retainers, bonds and expenses to be covered by the proposed advance to enable the Corporation to make an assessment of its reasonableness. The Corporation undertakes to advance the amounts hereunder by no later than ten
(10) business days following a written request made by the Indemnified Party, provided that such request contains the information and affirmations required hereunder. 

If, pursuant to Section 8 of this Agreement, the Corporation has no obligation or liability to indemnify the Indemnified Party under this
Agreement or any applicable laws, the Indemnified Party shall repay any monies that have been advanced to the Indemnified Party by the Corporation pursuant to this Agreement. 
  

	6.	 Derivative Actions 

In respect of an action by or on behalf of the Corporation (or by or on behalf of any other Group for which the Indemnified Party has acted or
is acting as director or officer or in a similar capacity at the request of the Corporation) to procure a judgement in its favour against the Indemnified Party, in respect of which the Indemnified Party is made a party by reason of being or having
been a director or officer of the Corporation (or by reason of being or having been a director or officer of, or serving or having served in a similar capacity for, another Group at the request of the Corporation), the Corporation will, upon request
of the Indemnified Party, make an application, at its expense, for the approval of a court of competent jurisdiction to advance monies to the Indemnified Party for costs, charges and expenses reasonably incurred by the Indemnified Party in
connection with such action and to indemnify and save harmless the Indemnified Party for such costs, charges and expenses of such action, in accordance with section 161 of the Business Corporations Act (Quebec). 

	7.	 Incidental Expenses 

Subject to Section 2, the Corporation shall pay or reimburse the Indemnified Party for the Indemnified Party’s reasonable and necessary travel,
lodging and accommodation costs, charges and expenses paid or incurred by or on behalf of the Indemnified Party in carrying out the Indemnified Party’s duties as a director or officer of the Corporation or another Group. 

 

	8.	 Limitation 

Except to the extent required by law, the indemnity described in this Agreement will not apply to: 

 

	 	(a)	 claims initiated by the Indemnified Party against the Corporation except for claims relating to the enforcement
of this Agreement, or 

  

	 	(b)	 claims initiated by the Indemnified Party against any other person or entity unless the Corporation has joined
with the Indemnified Party in, or has consented to the initiation of that Proceeding. This exception shall not apply to counter claims initiated by the Indemnified Party, which claims shall be covered by this Agreement. 

Furthermore, the Corporation will have no obligation or liability to indemnify the Indemnified Party under this Agreement if a court or other
competent authority concludes, by way of a final judgment, that: 
  

	 	(a)	 the Indemnified Party has not acted with honesty and loyalty in the interest of the Corporation, or, as the
case may be, in the interest of any other Group for which the Indemnified Party acted as director or officer or in a similar capacity at the request of the Corporation; or 

 

	 	(b)	 in the case of a Proceeding that is enforced by a monetary penalty, the Indemnified Party did not have
reasonable grounds for believing that the Indemnified Party’s conduct was lawful. 

 Likewise, the Corporation will
have no obligation or liability to indemnify the Indemnified Party under this Agreement if a court determines, by way of a final judgment, that the Indemnified Party has committed an intentional or gross fault. 

 

	9.	 Statutory Obligation to Indemnify 

Nothing in this Agreement in any way adversely affects or diminishes the obligation of the Corporation to indemnify the Indemnified Party
pursuant to section 159 of the Business Corporations Act (Quebec) or any other applicable law, statute or regulation. 
  

	10.	 Notice 

The Indemnified Party shall as soon as practicable notify the Corporation in writing upon being served with any summons, citation, subpoena,
complaint, indictment, information or other document commencing any Proceeding which may be subject to indemnification or advances under this Agreement, but no delay in providing such notice will in any way limit or affect the Indemnified
Party’s rights or the Corporation’s obligations under this Agreement or pursuant to the Business Corporations Act (Quebec). 

The Indemnified Party shall instruct his or her counsel to (i) keep the Corporation reasonably informed of its conduct of the defence of
any such Proceeding, except that in any such derivative Proceeding under Section 6, neither the Indemnified Party, nor its counsel, shall be required to inform the 

 
Corporation of its conduct of the defence and (ii) to provide the Corporation with copies of any documents served on the Indemnified Party in connection with such Proceeding or any other
relevant documents in the possession of the Indemnified Party, as soon as is practicable. The Indemnified Party shall cooperate fully in any investigation by the Corporation, including acting as a witness at the Corporation’s request, provided
it does not prejudice the Indemnified Party. 
 Any notice, consent or approval required or permitted to be given in connection with this
Agreement (in this Section referred to as a “Notice”) shall be in writing and shall be sufficiently given if delivered (whether in person, by courier service or other personal method of delivery), or if transmitted by facsimile or e-mail: 
 (a) in the case of a Notice to the Indemnified Party at: 

[                ] 

Fax:    
[                ] 
 E-mail: [                ] 

(b) in the case of a Notice to the Corporation at: 

Repare Therapeutics Inc. 

7210 Frederick-Banting Street 

Suite 100 
 Saint-Laurent
(Quebec) H4S 2A1 
 Attention: Chief Executive Officer 

E-mail:    [         
       ] 
 Any Notice delivered or transmitted to a party as provided above shall be deemed to
have been given and received on the day it is delivered or transmitted, provided that it is delivered or transmitted on a business day prior to 5:00 p.m. local time in the place of delivery or receipt. If the Notice is delivered or transmitted after
5:00 p.m. local time or if such day is not a business day, then the Notice shall be deemed to have been given and received on the next business day. 

Any party may, from time to time, change its address by giving Notice to the other party in accordance with the provisions of this Section.

  

	11.	 Independent Counsel 

Upon becoming aware of any Proceeding or Liabilities, the Indemnified Party will be entitled to retain independent legal counsel of the
Indemnified Party’s choosing until such time as it is determined that the Indemnified Party is not subject to any conflict of interest against the Corporation; provided, however, that the fees and disbursements of such counsel shall be at the
Indemnified Party’s expense unless engagement of such other counsel has been authorized by the Corporation (such authorization not to be unreasonably withheld), or judged by the court or other competent authority to be necessary to protect the
interests of the Indemnified Party, in which event, the fees and disbursements of such counsel shall be paid by the Corporation. 
  

	12.	 Absence of Presumption 

For purposes of Section 8 of this Agreement, the termination of any Proceeding, claim by judgment, order, settlement (whether with or
without court approval), or conviction, will not, of itself, create a presumption that the Indemnified Party did not meet any particular standard of conduct or have any particular belief or that a court has determined that indemnification is not
permitted by applicable law. 

	13.	 Duplication of Payments 

Subject to Section 2, the Corporation will not be liable under this Agreement to make any payment in connection with any claim made
against the Indemnified Party to the extent the Indemnified Party has otherwise actually received payment from any third party (under any insurance policy, including the directors’ and officers’ liability insurance policy described in
Section 15 below, by law, or otherwise) of the amounts otherwise subject to indemnification under this Agreement, unless such amounts have then subsequently been reimbursed by the Indemnified Party to the third party. 

 

	14.	 Settlement 

The Parties will act reasonably in pursuing the settlement of any Proceeding. The Corporation may not negotiate or effect a settlement of
claims against the Indemnified Party without the Indemnified Party’s consent, which may not be unreasonably withheld. The Indemnified Party may negotiate and effect a settlement without the consent of the Corporation but the Corporation will
not be liable for any settlement negotiated without its prior written consent, which may not be unreasonably withheld. No admission of liability shall be made by the Indemnified Party without the consent of the Corporation. 

 

	15.	 Directors’ & Officers’ Insurance 

The Corporation shall ensure that its liabilities under this Agreement are at all times supported by a directors’ and officers’
liability insurance policy, with a responsible insurer, that has been approved by the board of directors of the Corporation. The responsibility for obtaining and maintaining directors’ and officers’ liability insurance shall rest with a
senior manager of the Corporation, who shall retain an insurance broker or other person having expertise and experience in directors’ and officers’ liability insurance. The Corporation shall provide the Indemnified Party with a copy of
each policy of insurance providing the coverages contemplated by this Section promptly after coverage is obtained, and shall promptly notify the Indemnified Party in writing if the insurer cancels, makes material changes to coverage or refuses to
renew coverage (or any part of the coverage). The Corporation shall not do any act or thing (including changing insurers) or fail to do any act or thing, that could cause or result in a denial of insurance coverage or of any claim under such
coverage; without limiting the generality of the foregoing, the Corporation shall give prompt and proper notice to the insurer of any claim against the Indemnified Party. Notwithstanding the foregoing, the Corporation may, as an alternative or in
addition to obtaining or maintaining a directors’ and officers’ liability insurance policy, support its liabilities under this Agreement with a valid and irrevocable trust that provides substantially similar coverage to the Indemnified
Party as would a policy of insurance contemplated by this Section, as may be approved by the board of directors of the Corporation. 
  

	16.	 Taxes 

Should any payment made pursuant to this Agreement, including the payment of insurance premiums or any payment made by an insurer under an
insurance policy, be deemed to constitute a taxable benefit or otherwise be or become subject to any tax or levy, then the Corporation shall pay any amount as may be necessary to ensure that the amount received by or on behalf of the Indemnified
Party, after the payment of or withholding for such tax, fully reimburses the Indemnified Party for the actual cost, expense or liability incurred by or on behalf of the Indemnified Party. 

 

	17.	 Insolvency 

The liability of the Corporation under this Agreement shall not be affected, discharged, impaired, mitigated or released by reason of the
discharge or release of the Indemnified Party in any bankruptcy, insolvency, receivership or other similar proceeding of creditors. 

	18.	 Survival 

This Agreement shall continue in full force and effect after the Indemnified Party has ceased to be a director or officer (or serving in a
similar capacity) of the Corporation, or being a director or officer of (or serving in a similar capacity for) another Group at the request of the Corporation, and shall survive until thirty (30) days following the expiration of the statute of
limitations applicable to any and all Proceeding. 
  

	19.	 Deeming Provision 

The Indemnified Party shall be deemed to have acted or be acting at the specific request of the Corporation upon the Indemnified Party’s
being appointed or elected as a director or officer of the Corporation or any other Group. 
  

	20.	 Subrogation 

Subject to Section 2, to the extent permitted by law, the Corporation will be subrogated to all rights which the Indemnified Party may
have under all policies of insurance or other contracts pursuant to which the Indemnified Party may be entitled to reimbursement of, or indemnification in respect of, any Liabilities borne by the Corporation pursuant to this Agreement. 

 

	21.	 Waiver 

No waiver of any of the provisions of this Agreement will constitute a waiver of any other provision (whether or not similar) or be deemed to
be a waiver with respect to any other future instance involving the same provisions. No waiver will be binding unless executed in writing by the party to be bound by the waiver. A party’s failure or delay in exercising any right under this
Agreement will not operate as a waiver of that right. A single or partial exercise of any right will not preclude a party from any other or further exercise of that right or the exercise of any other right it may have. 

 

	22.	 Successors and Assigns 

This Agreement becomes effective immediately upon the closing of the Corporation’s initial public offering. After that time, it will be
binding upon and enure to the benefit of the Indemnified Party and the Indemnified Party’s successors, heirs, liquidators, executors, administrators and permitted assigns. 

Neither this Agreement nor any of the rights or obligations under this Agreement may be assigned, transferred, or delegated, in whole or in
part, by the Indemnified Party without the prior written consent of the Corporation. Any purported assignment, transfer or delegation without such written consent will be null and void and of no effect. The Corporation may assign, transfer or
delegate, as applicable, its obligations under this Agreement in whole or in part to any one of its affiliates, subsidiaries or successors without the Indemnified Party’s consent. 

 

	23.	 Severability 

If, in any jurisdiction, any provision of this Agreement is determined to be illegal, invalid or unenforceable, in whole or in part, by an
arbitrator or any court or other competent authority from which no appeal exists or is taken, that provision or part thereof will be severed from this Agreement and the remaining part of the provision and all other provisions will remain in full
force and effect. 
  

	24.	 Governing Law 

This Agreement is governed by, and is to be interpreted and enforced in accordance with, the laws of the province of Quebec and the federal
laws of Canada applicable therein. The Parties agree that the courts of the District of Montréal, province of Quebec, Canada, will have exclusive jurisdiction for the adjudication of any and all disputes or controversies arising out of or
relating directly or indirectly to this Agreement and waive any objections to the assertion or exercise of jurisdiction by such courts, including any objection based on forum non conveniens. 

	25.	 Entire Agreement 

Upon the effectiveness of this Agreement immediately upon the closing of the Corporation’s initial public offering, this Agreement shall
constitute the entire agreement between the Parties with respect to the matters contemplated herein and shall supersede all prior agreements, understandings, negotiations, correspondence and discussions, whether oral or written, entered into between
the Indemnified Party and the Corporation providing for indemnification or similar rights in relation to the Indemnified Party acting as a director or officer of the Corporation or as a director or officer of another Group, or serving in a similar
capacity, at the request of the Corporation. For greater certainty, once this Agreement becomes effective upon the closing of the Corporation’s initial public offering, this Agreement shall be effective from the date the Indemnified Party was
first elected or appointed as a director or officer of the Corporation. Notwithstanding the foregoing, if a signatory hereto has an employment agreement with the Corporation that provides additional indemnification protection not provided
herein (“Additional Indemnity”), such Additional Indemnity shall remain in full force and effect.  
  

	26.	 Further Assurances 

The Corporation and the Indemnified Party shall, with reasonable diligence, do all things and execute and deliver all such further documents or
instruments as may be necessary or desirable for the purpose of assuring and conferring on the Indemnified Party the rights created or intended by this Agreement and giving effect to and carrying out intention or facilitating the performance of the
terms of this Agreement. 
  

	27.	 Independent Legal Advice 

The Indemnified Party acknowledges that the Indemnified Party has been advised to obtain independent legal advice with respect to entering into
this Agreement, that the Indemnified Party has obtained such independent legal advice or has expressly determined not to seek such advice, and that the Indemnified Party is entering into this Agreement with full knowledge of the contents hereof, of
the Indemnified Party’s own free will and with full capacity and authority to do so. 
  

	28.	 Counterparts 

This Agreement may be signed and delivered in any number of counterparts (including by facsimile, email or other electronic means), each of
which is deemed to be an original, and such counterparts together constitute one and the same agreement. 
  

	29.	 English Language 

The Parties have agreed that this Agreement as well as any notice, document or instrument relating to it be drawn up in English only but
without prejudice to any such notice, document or instrument which may from time to time be drawn up in French only or in both French and English. Les parties aux présentes ont convenu que la présente convention ainsi que tout autre
avis, acte ou document s’y rattachant soient rédigés en anglais seulement mais sans préjudice à tout tel avis, acte ou document qui pourrait à l’occasion être rédigé en français
seulement ou à la fois en anglais et en français. 
 [Signature page follows] 

 IN WITNESS WHEREOF the Parties have executed this Agreement as of the date first
above written. 
  

							
		  		  	REPARE THERAPEUTICS INC.
				
		  		  	By:	  	  

		  		  		  	   Name:

  Title:

			
	     

  Witness (signature)
	  		  	     

  Signature of Indemnified Party

			
	     

  Witness Name (print)
	  		  	     

  Print or Type Name of Indemnified Party

 [Signature Page – Indemnification Agreement]EX-10.8

 Exhibit 10.8 
  

 
 

 
 EMPLOYMENT AGREEMENT 

This Employment Agreement (the “Agreement”) is entered into as of June 12, 2020, by and between Lloyd M. Segal
(the “Executive”) and Repare Therapeutics Inc. (the “Company”). 
 WHEREAS, the Company and
the Executive wish to enter into this Agreement to set forth the terms and conditions of the Executive’s continued employment with the Company effective and conditional on the pricing date of the initial public offering of the common shares of
the Company (the “Effective Date”). 
 NOW, THEREFORE, in consideration of the mutual covenants, promises and
obligations set forth herein, the parties agree as follows: 
 1.    Term. The Executive’s employment hereunder will commence
on the Effective Date and will continue for an indefinite term until terminated pursuant to Section 5. The period during which the Executive is employed by the Company hereunder is referred to as the “Term”. 

2.    Position and Duties. 

2.1    Position. During the Term, the Executive will serve as the President and Chief Executive Officer of the
Company, reporting directly to the Board of Directors of the Company (the “Board”). The Executive will have such duties, authority and responsibility as determined from time to time by the Board and as are
reasonably consistent with the Executive’s position, which duties will include, but not be limited to, those duties set forth in Appendix A hereto. 

2.2    Duties. During the Term, the Executive will devote his full business time and attention to the business of
the Company, carry out his duties and responsibilities to the best of his ability and use his best efforts to promote the interests of the Company and its affiliates. The Executive may manage his personal financial affairs (or that of his family
members), investments and charitable or philanthropic pursuits but may not engage in any outside business activities except to the extent that prior written approval has been given by the Board (which approval shall not be unreasonably withheld or
delayed) for such activities and provided that such other specific activities, collectively, do not materially conflict with the Business or materially interfere with the performance of the Executive’s duties or obligations hereunder (as
determined by the Board in its reasonable discretion). Notwithstanding the foregoing, however, so long as such activities do not materially interfere with the performance of his duties hereunder or his obligations to the Company, the Executive may,
consistent with Company policies, participate in any governmental, educational, professional, charitable or other community affairs during the Term. The Board has approved Executive’s service on GBC. 

3.    Place of Performance. The principal place of Executive’s employment will be at the Company’s offices in Montreal,
Quebec. The Executive acknowledges that the position involves reasonable travel on Company business, it being understood that the Executive’s work may be conducted remotely (if appropriate) and that travel will be limited while the COVID-19 pandemic persists. 

 4.    Compensation. 

4.1    Base Salary. The Company will pay the Executive an annual rate of base salary of $550,000 in accordance with
the Company’s normal payroll practices. The Executive’s base salary will be reviewed annually by the Compensation Committee of the Board (the “Compensation Committee”) and the Compensation Committee may, but will
not be required to, increase (but may not decrease) the base salary during the Term. The Executive’s base salary, as in effect from time to time, is referred to as “Base Salary”. 

4.2    Annual Bonus. For each calendar year of the Term, the Executive will have a target bonus opportunity equal
to 50% of the Base Salary (the “Target Bonus”). The Executive’s actual annual bonus (the “Annual Bonus”) may be greater or less than the Target Bonus. The Annual Bonus will be based on
achievement of one or more Company and/or individual performance goals established by the Compensation Committee in its discretion (provided that the Committee will seek Executive’s input with respect to such goals and will communicate
them in writing to Executive in a timely manner) and actual payout of the Annual Bonus will be determined by the Compensation Committee in its discretion based on achievement of the applicable performance goals for the relevant year. Except as
otherwise provided in this Agreement, to qualify for the Annual Bonus in respect of any calendar year, the Executive must remain continuously employed with the Company through February 15th of the
following calendar year. Any Annual Bonus payment will be paid by March 15th of the calendar year next following the year to which it relates. The Annual Bonus for the 2020 calendar year will be
determined based on the Executive’s target bonus opportunity and base salary in effect for the portion of the year prior to the Effective Date and the Executive’s Target Bonus and Base Salary in effect for the portion of the year on and
after the Effective Date. 
 4.3    Stock Options. On the Effective Date, the Company will grant to the Executive
stock options pursuant to the Repare Therapeutics Inc. 2020 Equity Incentive Plan (“EIP”) to acquire 354,668 common shares of the Company at the IPO price. The terms and conditions of the Executive’s stock options will
be set forth in an option agreement to be entered into between the Executive and the Company and governed by the EIP (the option agreement and the EIP, the “Equity Documents”). 

4.4    Employee Benefits. 

(a)    During the Term, the Executive and his eligible dependents shall be entitled to participate in the Company’s
standard employee health and family benefits programs in accordance with the terms of the Company’s Employee Benefits policy, as in effect from time to time. The Company reserves the right to amend the Employee Benefits policy at any time or
for any reason, subject to the terms of such policy and applicable law. 
 (b)    The Executive and his eligible
dependents will be entitled, at the Company’s expense, to an annual medical evaluation and a comprehensive executive health plan with a reputable service provider of his choice (with respect to both the evaluation and the plan), at normal
market rates for such benefits. 
 (c)    The Executive shall be entitled to professional accounting and tax preparation
and advice services at the Company’s expense, up to a maximum of $5,000 per year. 
 4.5    Vacation. During
the Term, the Executive will be entitled to four (4) weeks of paid vacation per calendar year (pro-rated for partial years) in accordance with the Company’s vacation policy as in effect from
time to time, including as to usage, carryover and payment for unused vacation. 

  
 2 

 4.6    Business Expenses and Relocation Expenses. The Executive
will be entitled to reimbursement for all reasonable and normal direct and out-of-pocket business expenses incurred by the Executive in connection with the performance
of his duties hereunder, including without limitation, business travel expenses, reasonable home office expenses, and expenses relating to a cellular data plan for a mobile phone and hotspot, providing both domestic and international coverage, upon
the Executive’s presentation of valid receipts, expense statements or other supporting documentation for such expenses as the Company may reasonably require. Further, the Company will reimburse the Executive for all reasonable and necessary
costs incurred in connection with any cross-border tax filings that may be required, as well as the cost of joining the NEXUS program and any other visa or related issues with respect to the Executive’s employment with the Company. To the
extent the Executive is subject to additional taxes in respect of services performed in the United States (whenever such services were performed on the Company’s behalf), the Company will reimburse the Executive for such additional taxes, with
an appropriate gross up calculation, such that the Executive pays no more income taxes in respect of compensation from the Company than he would have paid had the services solely been performed in Canada. 

4.7    Indemnification. The Executive will be covered by the Company’s directors’ and officers’
liability insurance coverage as in effect from time to time (which shall include reasonable, market terms, including tail coverage) and the Indemnification Agreement that the Company is providing to Executive in connection herewith. 

5.    Termination of Employment. The Term and the Executive’s employment hereunder may be terminated by either the Company or
the Executive at any time and for any reason. Upon such termination, the Executive will be entitled to the compensation and benefits described in this Section 5 and will have no further rights to any compensation or any other benefits from the
Company or any of its affiliates. 
 5.1    For Cause. The Executive’s employment hereunder may be
terminated by the Company for Cause. In the event of such termination, the Executive will be entitled to receive: 

(a)    any accrued but unpaid Base Salary and accrued but unused vacation in accordance with Company policy, which will be
paid on the pay date immediately following the Termination Date (as defined below); 
 (b)    reimbursement for
unreimbursed business expenses properly incurred by the Executive, which will be paid in accordance with the Company’s expense reimbursement policy; and 

(c)    all other vested payments, benefits or fringe benefits to which the Executive may be entitled under the terms of
any applicable compensation arrangement or benefit or fringe benefit plan or program or grant as of the Termination Date, if any; provided that, in no event will the Executive be entitled to any payments in the nature of severance or termination
payments except as specifically provided herein (Items 5.1(a) through 5.1(c) are referred to herein collectively as the “Accrued Obligations”). 

For purposes of this Agreement, “Cause” means: 
  

	 	(i)	 the Executive’s willful and repeated failure to perform his material duties without lawful justification
(other than any such failure resulting from incapacity due to physical or mental illness); 

  

	 	(ii)	 the Executive’s willful and repeated failure to comply with any material, valid and legal directive of the
Board; 

  
 3 

	 	(iii)	 the Executive’s engagement in dishonesty, illegal conduct or misconduct, which is, in each case,
materially injurious to the Company or its affiliates; 

  

	 	(iv)	 the Executive’s embezzlement, misappropriation or fraud, whether or not related to the Executive’s
employment with the Company, other than the occasional, customary and de minimis use of Company property for personal purposes; 

  

	 	(v)	 the Executive’s conviction of or plea of guilty to an indictable offense that is materially connected to
his employment or that could bring the reputation of the Company into disrepute; 

  

	 	(vi)	 the Executive’s willful violation of a material written employment policy of the Company which is
materially injurious to the Company or its affiliates; or 

  

	 	(vii)	 the Executive’s material breach of any material obligation under this Agreement or any other written
agreement referenced herein; 

 Termination of the Executive’s employment shall not be deemed to be for Cause unless the Company
delivers to the Executive written notice that an event constituting Cause has occurred and such notice specifies the details of such event. Except for a failure, breach or refusal which, by its nature, cannot reasonably be expected to be cured, the
Executive will have 30 days from his receipt of such written notice from the Company within which to cure any acts constituting Cause. The events set forth in clauses (i), (ii), (vi) and (vii) are presumed to be curable. 

5.2    Resignation by Executive. The Executive’s employment hereunder may be terminated upon the Executive
providing a notice of resignation with at least 60 days’ written notice. In the event of any such termination, the Executive will be entitled to receive the Accrued Obligations. 

5.3    Termination Without Cause. The Term and the Executive’s employment hereunder may be
terminated by the Company without Cause at any time. In the event of any such termination, the Executive will be entitled to receive the Accrued Obligations and any earned but unpaid Annual Bonus for the year immediately preceding the year in which
the Executive’s employment terminates, and subject to the Executive’s compliance with Section 7, Section 8, Section 9 and Section 10 and his execution of a release of claims in favor of the Company, its affiliates and
their respective officers and board members in a form acceptable to the Company (the “Release”) and such Release becoming effective, the Executive will be entitled to receive: 

(a)    an amount equal to 12 months’ of the Executive’s Base Salary in effect on the Termination Date, payable in
equal monthly installments over 12 months, the first of which will commence on the first payroll period following the date the Release becomes effective, and the initial payment shall include a catch-up
payment to cover amounts retroactive to the date immediately following the Termination Date, 
 (b)    continued
participation in the Company’s group insurance plans (except for short-term and long-term disability which shall cease on the Termination Date) and Employee Benefits described in Section 4.4, in each case for 12 months, subject to the
terms and conditions of the applicable plan and approval of the insurance carrier, 

  
 4 

 (c)    notwithstanding anything to the contrary in any applicable option
agreement, all stock options that are subject to a time-based vesting schedule that are held by the Executive which would have vested if the Executive had remained employed for an additional 12 months following the Termination Date shall vest and
become exercisable effective as of the Termination Date and shall remain exercisable until the earlier of (i) the expiration of the term of such stock options and (ii) and 12 months following the Termination Date, and 

(d)    an Annual Bonus paid at the Target Bonus level for the calendar year in which the Executive’s employment is
terminated, pro-rated for the period from the beginning of the calendar year up to the Termination Date ((a) through (d) collectively, the “Severance Benefits”). 

5.4    Termination for Good Reason. The Term and the Executive’s employment hereunder may be terminated by the
Executive for Good Reason at any time. In the event of any such termination, the Executive will be entitled to receive the Accrued Obligations and any earned but unpaid Annual Bonus for the year immediately preceding the year in which the
Executive’s employment terminates, and subject to the Executive’s compliance with Section 7, Section 8, Section 9 and Section 10 and his execution of a Release, the Executive will be entitled to receive the Severance
Benefits (payable in accordance with Section 5.3 above). 
 For purposes of this Agreement, “Good Reason” means the
Executive’s resignation following the occurrence of one of the following events without Executive’s consent: 
  

	 	(i)	 a material adverse change in the nature or scope of the Executive’s responsibilities, authorities, powers,
reporting structure, functions or duties; 

  

	 	(ii)	 a material reduction (i.e., 5% or more) in Executive’s Base Salary (other than, prior to a Change in
Control, a general reduction in Base Salary that is approved by the Board in connection with the Company’s financial distress and that affects all similarly situated executives in substantially the same proportion) or the amount of the
Executive’s Target Bonus opportunity; 

  

	 	(iii)	 the Company requires Executive to relocate to a location more than a 25 mile radius from the Company’s
current Montreal office; or 

  

	 	(iv)	 any action or inaction that constitutes a material breach by the Company of this Agreement;

 provided, that in each case (a) written notice of Executive’s resignation for Good Reason must be delivered to
the Company within 90 days after the initial occurrence of any such event, (b) the Company and/or its affiliates must have thirty (30) days to adequately cure such event, and (c) Executive must tender his resignation within 30 days
after the Company’s failure to cure such event, in order for Executive’s resignation with Good Reason to be effective hereunder. 

5.5    Death. The Executive’s employment hereunder will terminate automatically upon the Executive’s
death during the Term. In the event of such termination, the Executive or the Executive’s estate or beneficiaries, as the case may be, will be entitled to receive the Accrued Obligations and the benefits described in Sections 5.3(b)-5.3(c). 

  
 5 

 5.6    Disability. If the Executive’s employment is
terminated during the Term on account of the Executive’s Disability, the Executive will be entitled to receive the Accrued Obligations and the benefits described in Sections 5.3(b)-5.3(c). 

For purposes of this Agreement, “Disability” means the Executive is entitled to receive long-term disability benefits under the
Company’s long-term disability plan, or if there is no such plan, the Executive’s inability, due to physical or mental incapacity, to substantially perform his duties and responsibilities under this Agreement for 180 days out of any 365
day period or 120 consecutive days. Any question as to the existence of the Executive’s Disability as to which the Executive and the Company cannot agree will be determined in writing by a qualified independent physician mutually acceptable to
the Executive and the Company. The determination of Disability made in writing to the Company and the Executive will be final and conclusive for all purposes of this Agreement. For the avoidance of doubt, the Company will comply with all applicable
requirements under applicable employment standards legislation and human rights legislation with respect to any disability, including any applicable requirements regarding medical leave and accommodation. 

5.7    Change in Control Termination. Notwithstanding any other provision contained herein, if the Executive’s
employment hereunder is terminated by the Executive for Good Reason or by the Company without Cause (other than on account of the Executive’s death or Disability), in each case within 90 days prior to or within 12 months following a Change in
Control, the Executive shall be entitled to receive the Accrued Obligations and any earned but unpaid Annual Bonus for the year immediately preceding the year in which the Executive’s employment terminates, and subject to the Executive’s
compliance with Section 7, Section 8, Section 9 and Section 10 and his execution of a Release and such Release becoming effective, the Executive will be entitled to receive: 

(a)    an amount equal to 1.5 times the sum of (i) the Executive’s Base Salary in effect on the Termination Date
and (ii) the higher of the Executive’s Target Bonus in effect for the year in which the Termination Date occurs or the Executive’s Annual Bonus received for the preceding calendar year, payable in a lump sum on the first payroll
period following the date the Release becomes effective, 
 (b)    continued participation in the Company’s group
insurance plans (except for short-term and long-term disability which shall cease on the Termination Date) and Employee Benefits described in Section 4.4, in each case for 18 months, subject to the terms and conditions of the applicable plan
and approval of the insurance carrier, 
 (c)    notwithstanding anything to the contrary in any applicable option
agreement, all stock options that are subject to a time-based vesting schedule that are held by the Executive shall vest and become exercisable effective as of the Termination Date and shall remain exercisable until the earlier of (i) the
expiration of the term of such stock options and (ii) 15 months following the Termination Date, and 
 (d)    an Annual
Bonus paid at the Target Bonus level for the calendar year in which the Executive’s employment is terminated, pro-rated up to the Termination Date. 

For purposes of this Agreement, “Change in Control” has the meaning ascribed to such term in the EIP. 

5.8    Notice of Termination. Any termination of the Executive’s employment hereunder by the Company or by the
Executive during the Term (other than termination pursuant to Section 5.5 on account of the Executive’s death) will be communicated by written notice of termination (“Notice of Termination”) to the other party
hereto in accordance with Section 23. The Notice of Termination will specify (i) the termination provision of this Agreement relied upon, (ii) to the extent applicable, the facts and circumstances claimed to provide a basis for
termination of the Executive’s employment under the provision so indicated, and (iii) the applicable Termination Date, which will take into account any cure period required under Sections 5.1 or 5.4. 

  
 6 

 5.9    Termination Date. The Executive’s
“Termination Date” will be: 
 (a)    if the Executive’s employment hereunder terminates on
account of the Executive’s death, the date of the Executive’s death; 
 (b)    if the Executive’s
employment hereunder is terminated on account of the Executive’s Disability, the date that it is determined that the Executive has a Disability; 

(c)    if the Company terminates the Executive’s employment hereunder with or without Cause, the date specified in
the Notice of Termination; and 
 (d)    if the Executive terminates his employment hereunder for any reason, the date
specified in the Executive’s Notice of Termination, which will be no less than 60 days following the date on which the Notice of Termination is delivered; provided that, the Company reserves the right to waive all or any part of the 60-day notice period giving written notice to the Executive of such waiver and payment in lieu of such notice (including paying to Executive any amounts that would have accrued during such 60-day notice period, including the Employee Benefits), and for all purposes of this Agreement, upon such waiver, the Executive’s Termination Date will be determined by reference to any such waiver and shall
not be deemed to be a termination by the Company hereunder. 
 5.10    Resignation of All Other Positions. Upon
termination of the Executive’s employment hereunder for any reason, the Executive will be deemed to have resigned from all positions that the Executive holds as an officer or member of the board (or a committee thereof) of the Company or any of
its affiliates and as a fiduciary or trustee of any benefit plans sponsored or maintained by the Company or any of its affiliates. 

6.    Cooperation. The parties agree that certain matters in which the Executive will be involved during the Term may necessitate
the Executive’s cooperation in the future. Accordingly, following the termination of the Executive’s employment for any reason, to the extent reasonably requested by the Board, the Executive will, upon reasonable advance notice, cooperate
with the Company in connection with matters arising out of the Executive’s service to the Company, including, without limitation, any litigation matters; provided that, the Company will make reasonable efforts to minimize disruption of the
Executive’s other activities. The Company will reimburse the Executive for reasonable expenses incurred in connection with such cooperation, including travel expenses and reasonable legal expenses, and will compensate the Executive at an hourly
rate for all time spent on such matters based on the Executive’s Base Salary on the Termination Date. 
 7.    Confidential
Information. The Executive acknowledges that the Company continually develops Confidential Information, that the Executive may develop Confidential Information for the Company and that the Executive may learn of Confidential Information during
the course of his employment. The Executive will comply with the policies and procedures of the Company for protecting Confidential Information and will not disclose to any person (except as required by applicable law or for the proper performance
of his duties and responsibilities to the Company), or use for his own benefit or gain, any Confidential Information obtained by the Executive incident to his employment or other association with the Company. The Executive understands that this
restriction will continue to apply after his employment terminates, regardless of the reason for such termination. 

  
 7 

 For purposes of this Agreement, “Confidential Information” means all confidential or
proprietary information, intellectual property (including trade secrets) and confidential facts relating to or used or proposed to be used in the business, affairs or property of the Company and its affiliates, including, without limitation
(i) all information which is confidential based upon its nature or the circumstances surrounding its disclosure, and (ii) any confidential information relating to the Company’s and its affiliates’ business policies, processes and
templates, strategies, operations, finances, plans or opportunities, in each case, which was acquired by the Executive during Executive’s employment with the Company (or during any negotiations in anticipation of such employment). The Executive
understands that the above list is not exhaustive, and that Confidential Information also includes other information that is marked or otherwise identified as confidential or proprietary, or that would otherwise appear to a reasonable person to be
confidential or proprietary in the context and circumstances in which the information is known or used. Confidential Information will not include information that is generally available to and known by the public at the time of disclosure to the
Executive; provided that, such disclosure is through no direct or indirect fault of the Executive or person(s) acting on the Executive’s behalf. 

Further, nothing in this Agreement will limit the Executive’s right to discuss his employment with, or report possible violations of law or regulation
to, federal or provincial government agencies to the extent that such disclosure is protected under the applicable provisions of law or regulation, including but not limited to “whistleblower” statutes or other similar provisions that
protect such disclosure. 
 8.    Non-solicitation. The Executive agrees that, during the
Term and for a period of 15 months after the Termination Date, he will not, and will not assist, directly or indirectly any other person to knowingly (i) solicit or induce in any capacity any employee of the Company or any of its
affiliates or solicit or seek to persuade any employee of the Company or any of its affiliates to discontinue such employment, or (ii) call on, solicit, induce, influence or encourage any independent contractor providing services to the Company
or any of its affiliates to terminate or diminish its relationship with them. Notwithstanding the foregoing, it shall not be a violation of this Section 8 to post a general advertisement for employees or other service providers not targeted at
Company employees nor by serving as a reference for an employee with regard to an entity with which the Executive is not affiliated). 
 The
Executive further agrees that, during the Term and for a period of 15 months after the Termination Date, he will not, and will not assist, directly or indirectly any other person to (i) canvass or solicit the business of, or procure or assist
the canvassing or soliciting of the business of, any Customer (as defined below) or Supplier (as defined below) for any purpose which is in competition, in whole or in part, with the Business (as defined below); (ii) accept, or procure or
assist the acceptance of, any business from any Customer, for any purpose which is in competition, in whole or in part, with the Business, in all or part of the Territory (as defined below); (iii) supply, or procure or assist the supply of, any
goods or services to any Customer, for any purpose which is in competition, in whole or in part, with the Business, in all or part of the Territory; or interfere or attempt to interfere with the Business by persuading or attempt to persuade any
Customer or Supplier to discontinue or alter in an adverse manner such Person’s (as defined below) relationship with the Business. 

9.    Non-competition. The Executive agrees that, during the Term and for a period of
fifteen (15) months after the Termination Date, he will not, without the prior written consent of the Board, directly or indirectly, (i) for himself, or (ii) as a consultant, independent contractor, manager, supervisor,
employee, stockholder, investor, officer, director or owner of, or lender to, a Competing Business (as defined below), engage in any Competitive Business in which he provides services which are the same or substantially similar to the duties he
performs as an employee of the Company in all or part of the Territory; provided, however, that the foregoing covenant will not be deemed to prohibit the Executive from acquiring, solely as an investment and through market purchases, publicly-traded
securities of any corporation so long as the Executive does not own 3% or more of the same class of securities of such corporation; provided further that the foregoing covenant shall not prohibit Executive from working for an organization that has a
division or unit that engages in the Business as long as Executive is not providing services to such division or unit. 

  
 8 

 For the purposes of this Agreement: 

 

	 	(i)	 “Business” means the discovery, research, development and commercialization of oncology
treatments for drug targets currently under active discovery, development or commercialization (generally referred to internally as “Programs”, “Pipeline” and “Hopper”) by the Company and its affiliates, including
material external sponsored research agreements; 

  

	 	(ii)	 “Competing Business” means any person, concern or entity which is engaged in or
conducts a business substantially the same as the Business of the Company or its affiliates; 

  

	 	(iii)	 “Customer” shall mean any and all Persons, who during the Term or, in the case of
termination of the Executive’s employment, in the twenty-four (24) months preceding the Termination Date, has purchased products or services from the Company in connection with the Business; 

 

	 	(iv)	 “Person” shall mean an individual, partnership, limited partnership, limited liability
partnership, corporation, limited liability company, unlimited liability company, joint stock company, trust, unincorporated association, joint venture or other entity or governmental entity, and pronouns have a similarly extended meaning;

  

	 	(v)	 “Supplier” shall mean any and all Persons, who during the Term or, in the case of
termination of the Executive’s employment, in the twenty-four (24) months preceding the Termination Date, has sold products or services from the Company in connection with the Business; 

 

	 	(vi)	 “Territory” means the city of Montreal and the Greater Boston Area.

 10.    Non-disparagement. The Executive agrees and covenants that he
will not at any time make, publish or communicate to any person or entity or in any public forum any defamatory or intentionally disparaging remarks, comments or statements concerning the Company or its businesses, or any of its employees or
officers. The Company also agrees and covenants that it will use commercially reasonable efforts to cause the officers, directors and spokespersons of the Company to not at any time make, publish or communicate to any person or entity in any public
forum any defamatory or intentionally disparaging remarks, comments or statements concerning the Executive. Notwithstanding the foregoing, statements made (i) in the course of sworn testimony in administrative, judicial or arbitral proceedings
(including, without limitation, depositions in connection with such proceedings) or (ii) in the normal course of business and in connection with the Executive’s performance of his job duties (such as, for example, providing negative
performance feedback to direct reports) shall not be subject to this Section 10. 
 11.    Acknowledgement. 

11.1    The Executive acknowledges and agrees that (i) the services to be rendered by him to the Company are
of a special and unique character, (ii) the Executive will obtain knowledge and skill relevant to the Company’s industry, methods of doing business and marketing strategies by virtue of the Executive’s employment, and (iii) the
restrictive covenants and other terms and conditions of this Agreement are reasonable and reasonably necessary to protect the legitimate business interest of the Company. 

  
 9 

 11.2    The Executive acknowledges and agrees that (i) the amount
of his compensation reflects, in part, his obligations and the Company’s rights under Section 7, Section 8, Section 9 and Section 10, (ii) that he has no expectation of any additional compensation, royalties or other payment
of any kind not otherwise referenced herein in connection herewith, and (iii) that he will not be subject to undue hardship by reason of his full compliance with the terms and conditions of Section 7, Section 8, Section 9 and
Section 10 or the Company’s enforcement thereof. 
 12.    Remedies. In the event of a breach or threatened breach by
the Executive of Section 7, Section 8, Section 9 and Section 10, the Executive hereby consents and agrees that the Company will be entitled to seek, in addition to other available remedies, specific performance, a temporary or
permanent injunction or other equitable relief against such breach or threatened breach from any court of competent jurisdiction, without the necessity of showing any actual damages or that money damages would not afford an adequate remedy, and
without the necessity of posting any bond or other security. Such equitable relief will be in addition to, not in lieu of, legal remedies, monetary damages or other available forms of relief. 

13.    Proprietary Rights. 

13.1    Work Product. The Executive acknowledges and agrees that all writings, works of authorship, software,
inventions, ideas and other work product of any nature whatsoever, that are created, prepared, produced, authored, edited, amended, conceived or reduced to practice by the Executive individually or jointly with others during the Term and relating in
any way to the business or contemplated business or development of the Company (regardless of when or where the Work Product is prepared or whose equipment or other resources is used in preparing the same) and all printed, physical and electronic
copies, all improvements, rights and claims related to the foregoing, and other tangible embodiments thereof (collectively, “Work Product”) will be the sole and exclusive property of the Company. For purposes of this
Agreement, Work Product includes, but is not limited to, Company information, including plans, publications, strategies, agreements, documents, contracts, terms of agreements, negotiations, manuals, reports, market studies, formulae, notes,
communications, marketing information, advertising information and sales information. 
 13.2    Assignment of
Rights. The Executive will promptly and fully disclose all Work Products to the Company. The Executive hereby assigns and agrees to assign to the Company (or as otherwise directed by the Company) the Executive’s full right, title and
interest in and to all Work Products. The Executive agrees to execute any and all applications for domestic and foreign patents, copyrights or other proprietary rights and to do such other acts (including without limitation the execution and
delivery of instruments of further assurance or confirmation) requested by the Company to assign the Work Products to the Company and to permit the Company to enforce any patents, copyright or other proprietary rights to the Work Products. The
Executive will not charge the Company for time spent in complying with these obligations. All copyrightable works that the Executive creates will be considered “work made for hire”. The Executive irrevocably waives to the greatest extent
permitted by law, for the benefit of the Company, all the Executive’s moral rights (if any) in the Work Products, including any right to the integrity of any Work Products, any right to be associated with any Work Products and any right to
restrict or prevent the modification or use of any Work Products in any way whatsoever. 
 14.    Return of Property. Upon
(i) termination of the Executive’s employment for any reason, or (ii) the Company’s request at any time during the Executive’s employment, the Executive will return to the Company all property belonging to the Company and
its predecessors, successors, affiliates or related companies, including all documents in any format whatsoever, including electronic format, that is in his possession or control, and the Executive agrees not to retain any copies of such property in
any format whatsoever. 

  
 10 

 15.    Governing Law: Jurisdiction and Venue. This Agreement, for all purposes,
will be construed in accordance with the laws of the province of Quebec (and the federal laws of Canada applicable therein) without regard to conflicts of law principles. Any action or proceeding by either of the parties to enforce or to adjudicate
a dispute under this Agreement will be brought only in a provincial or federal court located in the judicial district of Montreal, Quebec. The parties hereby irrevocably submit to the exclusive jurisdiction of such courts and waive the
defense of inconvenient forum to the maintenance of any such action or proceeding in such venue. 
 16.    Entire Agreement.
Unless specifically provided herein, this Agreement and the Equity Documents contain all of the understandings and representations between the Executive and the Company pertaining to the subject matter hereof and supersedes all prior and
contemporaneous understandings, agreements, representations and warranties, both written and oral, with respect to such subject matter, including without limitation, the Executive’s employment agreement dated July 1, 2017; provided that
any previous option agreements with respect to previous equity awards remain in full force and effect. The parties mutually agree that the Agreement can be specifically enforced in court and can be cited as evidence in legal proceedings alleging
breach of the Agreement. 
 17.    Modification and Waiver. No provision of this Agreement may be amended or modified unless such
amendment or modification is agreed to in writing and signed by the Executive and by the Company. No waiver by either of the parties of any breach by the other party hereto of any condition or provision of this Agreement to be performed by the other
party hereto will be deemed a waiver of any similar or dissimilar provision or condition at the same or any prior or subsequent time, nor will the failure of or delay by either of the parties in exercising any right, power or privilege hereunder
operate as a waiver thereof to preclude any other or further exercise thereof or the exercise of any other such right, power or privilege. 

18.    Severability. Should any provision of this Agreement be held by a court of competent jurisdiction to be enforceable only if
modified, or if any portion of this Agreement will be held as unenforceable and thus stricken, such holding will not affect the validity of the remainder of this Agreement, the balance of which will continue to be binding upon the parties with any
such modification to become a part hereof and treated as though originally set forth in this Agreement. 
 The parties further agree that any such court is
expressly authorized to modify any such unenforceable provision of this Agreement in lieu of severing such unenforceable provision from this Agreement in its entirety, whether by rewriting the offending provision, deleting any or all of the
offending provision, adding additional language to this Agreement or by making such other modifications as it deems warranted to carry out the intent and agreement of the parties as embodied herein to the maximum extent permitted by applicable law.

 The parties expressly agree that this Agreement as so modified by the court will be binding upon and enforceable against each of them. In any event,
should one or more of the provisions of this Agreement be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability will not affect any other provisions hereof, and if such provision or provisions
are not modified as provided above, this Agreement will be construed as if such invalid, illegal or unenforceable provisions had not been set forth herein. 

19.    Captions. Captions and headings of the sections and paragraphs of this Agreement are intended solely for convenience and no
provision of this Agreement is to be construed by reference to the caption or heading of any section or paragraph. 

20.    Counterparts. This Agreement may be executed in separate counterparts, each of which will be deemed an original, but all of
which taken together will constitute one and the same instrument. 

  
 11 

 21.    Tolling. Should the Executive violate any of the terms of the restrictive
covenant obligations articulated herein, the obligation at issue will run from the first date on which the Executive ceases to be in violation of such obligation. 

22.    Successors and Assigns. This Agreement is personal to the Executive and will not be assigned by the Executive. Any purported
assignment by the Executive will be null and void from the initial date of the purported assignment. The Company may assign this Agreement to any successor or assign (whether direct or indirect, by purchase, merger, consolidation or otherwise) to
all or substantially all of the business or assets of the Company. This Agreement will inure to the benefit of, and be binding upon, the Company and its successors and assigns. The Company hereby reserves the right to assign this Agreement to an
affiliate upon written notice to the Executive and the Executive hereby consents to such assignment. 
 23.    Notice. Notices
and all other communications provided for in this Agreement will be in writing and will be delivered personally or sent by registered or certified mail, return receipt requested, or by overnight carrier to the parties at the addresses set forth
below (or such other addresses as specified by the parties by like notice): 
 If to the Company: 

Repare Therapeutics Inc. 
 7210
Frederick-Banting, Suite 100 
 St. Laurent, QC H4S 2A1 

Attn: Chairman of the Board of Directors 

If to the Executive: 
 Lloyd Segal

 [ADDRESS] 

24.    Currency. All dollar amounts herein are in US dollars. 

25.    Withholding. The Company will have the right to withhold from any amount payable hereunder any Federal, provincial and other
taxes in order for the Company to satisfy any withholding tax obligation it may have under any applicable law or regulation. 

26.    Survival. Upon the termination of this Agreement, the respective rights and obligations of the parties hereto will survive
such termination to the extent necessary to carry out the intentions of the parties under this Agreement. 
 27.    Employment
Standards; Failsafe. It is understood and agreed that all provisions herein are subject to all applicable minimum requirements under applicable employment standards legislation. In the event that the applicable employment standards legislation
provides for superior entitlements upon termination of employment or otherwise (“statutory entitlements”) than provided for herein, the Company shall provide the Executive with his statutory entitlements in substitution for his rights
hereunder. 
 The Executive acknowledges and agrees that any payments of Severance Benefits or payments under Section 5.7 that are in excess of the
applicable minimum requirements of applicable employment standards legislation shall be subject and conditional on signing the Release. If the Executive does not deliver such Release to the Company within 60 days following the Termination Date, the
Executive will instead only receive such payments as are required by applicable minimum requirements of applicable employment standards legislation. The Executive agrees that the foregoing arrangements constitute reasonable notice in accordance with
the civil law and that the Executive will not be entitled to further notice of termination, payment in lieu of notice or any indemnity, severance pay, incentive compensation, damages or other compensatory payments under common law, civil law or
contract. 

  
 12 

 28.    Language. The Parties hereto acknowledge that they have requested and are
satisfied that this Agreement and all related documents be drawn up in the English language. Les parties aux présentes reconnaissent avoir requis que la présente entente et les documents qui y sont relatifs soient rédigés
en anglais. 
 29.    Acknowledgment of Full Understanding. THE EXECUTIVE ACKNOWLEDGES AND AGREES THAT HE HAS FULLY READ,
UNDERSTANDS AND VOLUNTARILY ENTERS INTO THIS AGREEMENT. THE EXECUTIVE ACKNOWLEDGES AND AGREES THAT HE HAS HAD AN OPPORTUNITY TO ASK QUESTIONS AND CONSULT WITH AN ATTORNEY OF HIS CHOICE BEFORE SIGNING THIS AGREEMENT. 

[SIGNATURE PAGE FOLLOWS] 

  
 13 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first
above written. 
  

	
	REPARE THERAPEUTICS INC.
	
	 /s/ Jerel Davis

	
	 Per: Jerel Davis,
 Chairman
of the Board of Directors

 I have read the above Agreement and I confirm that I have understood the terms thereof and that I have had sufficient
opportunity to obtain independent legal advice. By signing below, I accept the terms set out in the above Agreement. 
  

							
	 /s/ Lloyd M. Segal
	    	Date:	 	 June 12, 2020
	 	
				
	Lloyd Segal	    		 		 	

  
 14 

 Appendix A 

[PROVIDED SEPARATELY] 

  
 15

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