Document:

exv10w46

Exhibit 10.46

[*] = Certain confidential information contained in this document, marked by brackets, has
been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule
24b-2 of the Securities Exchange Act of 1934, as amended.

AMENDMENT NO. 2 TO MANUFACTURING AND SUPPLY 

AGREEMENT

THIS AMENDMENT NO. 2 TO MANUFACTURING AND SUPPLY AGREEMENT (“Amendment No. 2”) is made and entered
into as of February 15, 2011 (the “Effective Date of Amendment No. 2”) by and between Alexza
Pharmaceuticals, Inc., a Delaware corporation having an address at 2091 Stierlin Court, Mountain
View, CA 94043 (“Alexza”) and Autoliv ASP, Inc., an Indiana corporation having an address at 3350
Airport Road, Ogden Utah 84405 (“Autoliv”).

WHEREAS Alexza and Autoliv are parties to a Manufacturing and Supply Agreement dated November 2,
2007 (the “Agreement”) and amended by Amendment No. 1 to Manufacturing and Supply Agreement dated
as of June 30, 2010 (“Amendment No. 1”); and

WHEREAS the parties now wish to further amend the Agreement;

NOW, THEREFORE, in consideration of the foregoing and the covenants and promises contained in this
Amendment No. 2 and in accordance with and subject to the terms and conditions specified below, the
parties agree as follows:

Amendment of the Agreement

The parties hereby agree to amend the Agreement as of the Effective Date of this Amendment No. 2 as
provided below. Capitalized terms used in this Amendment No. 2 that are not otherwise defined
herein shall have the meaning ascribed to them in the Agreement or Amendment No. 1, as the case may
be.

	 	1.	 	Adjustment of Principal Amount of Promissory Note; Payment for Second Cell. The
parties acknowledge that Alexza has requested that Autoliv cease work on the second cell
of the first Commercial Production Line, and pursuant to Section 5.4 (iii) of the
Agreement as amended the parties agree that (a) the principal amount of the Note is hereby reduced to
$2.8 million, (b) the monthly payments on the Note will be $67,903.49 and (c) Alexza will
make the first payment upon

 

 

	 	 	 	the Effective Date of Amendment No. 2. Autoliv will return the
existing Note, and Alexza will issue a new Note in the form attached as Exhibit 1 hereto.
In the event and to the extent that Alexza requests in writing that Autoliv shall provide
the second cell of the First Commercial Production Line Autoliv shall complete, install and
fully qualify such second cell at a cost of $1,200,000 in accordance with the terms and
conditions of Section 5.4 (iv) of the Agreement as amended.
	 
	 	2.	 	Clarification regarding pricing. The Parties agree that pursuant to Section 3.3 of
the Agreement the prices set forth in Exhibit C of the Agreement apply to annual volumes
purchased by Alexza. By way of illustration and for purposes of clarification, if in a
year Alexza purchases [*] Heat Packages, the price per Heat package will be $[*] and the
total cost to Alexza for the [*] Heat Packages will be $[*].
	 
	 	3.	 	Miscellaneous.

	 	(i)	 	Full Force and Effect. Except as expressly amended by this amendment
No. 2, the Agreement as amended by Amendment No. 1 shall remain unchanged and shall
continue in full force and effect as provided therein.
	 
	 	(ii)	 	Entire Agreement of the Parties. This Amendment No. 2, Amendment
No. 1, the Agreement and the Exhibits hereto and thereto, constitute the complete,
final and exclusive understanding and agreement of the parties with respect to the
subject matter of the Agreement and supersede any and all prior or contemporaneous
negotiations, correspondence, understandings and agreements, whether oral or written,
between the parties respecting the subject matter of the Agreement.
	 
	 	(iii)	 	Counterparts. This Amendment No. 2 may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument.

 2 

[*] = Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of
the Securities Exchange Act of 1934, as amended.

 

 

IN WITNESS WHEREOF, the parties have executed this Amendment No. 2 in duplicate originals by
their authorized officers as of the Effective Date of Amendment No. 2.

	 	 	 	 	 	 	 	 	 	 	 

	 	 	ALEXZA PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	By	 	   /s/ August J. Moretti	 	 
	 	 	 	 	 	 	 
	 	 	Print name	 	   August J. Moretti	 	 
	 	 	Title	 	  CFO	 	 
	 	 	 	 	 	 	 	 	 

	 	 	 	 	 	 	 	 	 	 	 

	 	 	AUTOLIV ASP, INC.	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	By	 	  /s/ Michael J. Ward	 	 
	 	 	 	 	 	 	 
	 	 	Print name	 	   Michael J. Ward	 	 
	 	 	Title	 	  President	 	 
	 	 	 	 	 	 	 	 	 

 3 

[*] = Certain confidential information contained in this document, marked by brackets, has been
omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of
the Securities Exchange Act of 1934, as amended.exv10w47

Exhibit 10.47

Unsecured Promissory Note

Dated February 15, 2011

For value received, Alexza Pharmaceuticals, Inc., a Delaware corporation (“Alexza” or “Maker”),
whose address is 2091 Stierlin Court, Mountain View, California 94043, promises to pay to the order
of Autoliv ASP, Inc., an Indiana corporation (“Autoliv” or “Payee”), whose address is 3350 Airport
Road, Ogden, UT 84405, at such place as Payee may designate, the principal sum of Two Million Eight
Hundred Thousand Dollars ($2,800,000.00), plus interest on the unpaid principal balance from
January 1, 2011 until all amounts outstanding hereunder are paid in full at a fixed interest rate
of eight percent (8%) per annum, to be paid in lawful money of the United States in Forty-Eight
(48) consecutive equal monthly installments of principal and interest of Sixty-Seven Thousand Nine
Hundred Three Dollars and Forty-Nine Cents ($67,903.49).

The first monthly installment shall be due and payable on January 15, 2011 and subsequent monthly
installments shall be due and payable on the first day of each succeeding month; provided that any
payment due on a day that is not a business day shall be payable on the following business day.
Each payment may, at the option of the Payee, be calculated and applied on an assumption that such
payment would be made on its due date and that each year consists of twelve months of even
duration.

The acceptance of Payee of any payment which is less than payment in full of all amounts due and
owing at such time shall not constitute a waiver of Payee’s right to receive payment in full at
such time or at any prior or subsequent time.

Maker may, at any time, prepay in full or in part any indebtedness hereunder without penalty, which
prepayment shall be applied first to accrued but unpaid interest and then principal. If prepayment
is made in part, Maker will execute and tender, and Payee shall accept, a replacement note which
reflects the amortization of the remaining principal, plus interest, over the then-remaining
monthly installments.

This Note is issued pursuant to the terms and conditions of the Manufacturing and Supply
Agreement between Alexza and Autoliv dated November 2, 2007 as amended by Amendment No. 1 thereto
dated June 29, 2010 and Amendment No. 2 thereto dated February 15, 2011 (the “MSA”), and if any
amount payable hereunder is not paid when due, at the option of Autoliv and upon written notice
from Autoliv to Alexza, such failure to pay shall be deemed a material breach of the MSA by Alexza,
and Autoliv may terminate the MSA pursuant to Section 10.4(a) of the MSA.

It is the intention of the parties hereto to comply with the applicable usury laws; accordingly, it
is agreed that, notwithstanding any provision to the contrary in this Note, in no event shall this
Note require the payment or permit the collection of interest in excess of the maximum amount
permitted by applicable law. Except as otherwise

 

 

provided for herein, the Maker hereby waives presentment, demand for payment, notice of nonpayment,
protest, notice of protest, notice of dishonor, and all other notices in connection herewith, as
well as filing of suit (if permitted by law) and diligence in collecting this Note and agrees to
pay all reasonable, documented expenses incurred in collection, including Payee’s actual attorneys’
fees, upon demand.

	 	 	 	 	 

	ALEXZA PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 
	By:

	 	  /s/ August J. Moretti
 

	 	 
	 
	 	 	 	 
	Its:

	 	  CFOexv10w12

    EXHIBIT 10.12

 

    Director Annual

    Restricted Stock Unit Agreement

    Amended & Restated 2002 Plan

 

    DELL
    INC.

    Restricted Stock Unit Agreement

 

    Recipient:

 

    Date of Grant:

 

    Identification No.:

 

    Number of Units:

 

    Dell Inc., a Delaware Corporation (the “Company”), is
    pleased to grant you units representing shares of the
    Company’s common stock (the “Shares”), subject to
    the restrictions described below. The number of units awarded to
    you (the “Units”) is stated above. Each Unit
    represents one Share. This award is subject to the following
    terms and conditions.

 

    Restrictions — The Units are subject to
    the following restrictions (referred to herein as the
    “Restrictions”):

 

    Transfer Restrictions — You may not sell,
    assign, transfer, pledge or otherwise dispose of any Units with
    respect to which the Restrictions have not lapsed as described
    below.

 

    Expiration — If you cease to be a director for
    any reason other than your death, Permanent Disability, (as
    defined in the Plan described below) or retirement from the
    Board of Directors after attaining age 65 with a minimum of
    four years of service, any Units with respect to which the
    Restrictions have not lapsed as described below will expire at
    that time.

 

    Lapse of Restrictions — The Restrictions
    will lapse with respect to the Units, and you will be entitled
    to Shares, in accordance with the following schedule:

 

	 	 	 
	
    Number
	
 
	
    Date

	 

	

    33.34%

	
 
	
              

	

    33.33%

	
 
	
 

	

    33.33%

	
 
	
 

 

    If you cease to be a director by reason of your death, Permanent
    Disability, (as defined in the Plan described below) or
    retirement from the Board of Directors after attaining
    age 65 with a minimum of four years of service, the
    Restrictions will lapse immediately and automatically with
    respect to all Units upon such termination.

 

    Rights as a Stockholder — You will have
    no rights as a stockholder with respect to Shares that may be
    received by you upon the lapse of Restrictions until the
    Restrictions have lapsed and those Shares are registered in your
    name on the books of the Company’s transfer agent.

 

    Agreement With Respect to Taxes — You
    must pay any taxes that are required to be withheld by the
    Company. You may pay such amounts in cash or make other
    arrangements satisfactory to the Company for the payment of such
    amounts. You agree that if you do not pay, or make arrangements
    for the payment of, such amounts, the Company, to the fullest
    extent permitted by law, shall have the right to deduct such
    amounts from any payments of any kind otherwise due to you and
    shall have the right to withhold from Units for which
    Restrictions have lapsed the number of Shares having an
    aggregate market value at that time equal to the amount you owe.

 

    Black-Out Periods — In order to minimize
    the potential for prohibited “insider” trading, the
    Company may establish periods from time to time during which you
    may not engage in transactions involving the Company’s
    stock (“Black-Out Periods”). Notwithstanding any other
    provisions herein, Restrictions will not lapse with respect to
    any

 

    Units during an applicable Black-Out Period and the applicable
    period during which Units shall be subject to the Restrictions
    shall be extended until the end of such Black-Out Period.

 

    Incorporation of Plan — This award is
    granted the Company’s Amended and Restated 2002 Long-Term
    Incentive Plan and is governed by the terms of the Plan in
    addition to the terms and conditions stated herein. All terms
    used herein with their initial letters capitalized shall have
    the meanings given them in the Plan unless otherwise defined
    herein. A copy of the Plan is available upon request from the
    Company’s Stock Option Administration Department. Shares of
    common stock that are issued upon the lapse of Restrictions
    shall be made available from authorized but unissued shares.

 

    Prospectus — You may at any time obtain
    a copy of the prospectus related to your purchase of Dell common
    stock pursuant to this Unit award agreement by accessing the
    prospectus at
    http://inside.us.dell.com/legal/corporate.htm.
    Additionally, you may request a copy of the prospectus free of
    charge from the Company by contacting Stock Option
    Administration in writing at Stock Option Administration, One
    Dell Way, Mail Stop 8038, Round Rock, Texas 78682,
    (512) 728-8644
    or by e-mail
    at Stock_Option_Administrator@dell.com.

 

    Notice — You agree that notices may be
    given to you in writing either at your home address as shown in
    the records of the Company or by electronic transmission
    (including
    e-mail or
    reference to a website or other URL) sent to you through the
    Company’s normal process for communicating electronically
    with its directors.

 

    Data Privacy Consent — As a condition of
    the grant of the Units, you consent to the collection, use and
    transfer of personal data as described in this paragraph. You
    understand that the Company and its Subsidiaries hold certain
    personal information about you, including your name, home
    address and telephone number, date of birth, social security
    number, nationality, any shares of common stock held in the
    Company, and details of all options or other entitlements to
    shares of common stock awarded, cancelled, exercised, vested, or
    unvested (“Data”). You further understand that the
    Company and its Subsidiaries will transfer Data amongst
    themselves as necessary for the purposes of implementation,
    administration and management of your participation in the Plan,
    and that the Company and any of its Subsidiaries may each
    further transfer Data to any third parties assisting the Company
    in the implementation, administration and management of the
    Plan. You understand that these recipients may be located in the
    European Economic Area or elsewhere, such as the United States.
    You authorize them to receive, possess, use, retain and transfer
    such Data as may be required for the administration of the Plan
    or the subsequent holding of shares of common stock on your
    behalf, in electronic or other form, for the purposes of
    implementing, administering and managing your participation in
    the Plan, including any requisite transfer to a broker or other
    third party with whom you may elect to deposit any shares of
    common stock acquired under the Plan. You understand that you
    may, at any time, view such Data or require any necessary
    amendments to it.

 

    Acceptance of Terms and Conditions —
    This award will not be effective until you have acknowledged and
    agreed to the terms and conditions set forth herein by executing
    this agreement in the space provided below and returning it to
    the Company’s Stock Option Administration Department.

 

	 	 	 	 	 
	
 
	
 
	
 

	
    Awarded subject to the terms and conditions stated above:
	
 
	
    Accepted under the terms and conditions stated above

	
 
	
 
	
 

	
    DELL INC.
	
 
	
 

	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
    

    
Recipient’s
    Signature

	
 
	
 
	
 
	
 
	
 

	
    By:
	
 
	
    /s/ CRAIG A.
    BRISCOECraig
    A. Briscoe, VP,

    Global Compensation & Benefits

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