Document:

EX-10.1

 Exhibit 10.1 

FOURTH AMENDMENT 
 TO

 BUSINESS COMBINATION AGREEMENT 

This Fourth Amendment to Business Combination Agreement (the “Amendment”) is effective as of May 30, 2021, by and among
UpHealth Holdings, Inc., a Delaware corporation (“Holdings”), GigCapital2, Inc., a Delaware corporation (“GigCapital2”) and UpHealth Merger Sub, Inc., a Delaware corporation (“Merger Sub,” and
together with Holdings and GigCapital2, the “Parties,” and individually, a “Party”). Certain capitalized terms used in this Amendment and not otherwise defined herein shall have the meaning ascribed to such terms in
the BCA (as defined below). 
 RECITALS 

WHEREAS, Holdings, GigCapital2 and Merger Sub are parties to that certain Business Combination Agreement dated as of November 20, 2020
(the “BCA”), as subsequently amended, pursuant to which Holdings intends to merge with Merger Sub, with Holdings surviving the merger as a wholly owned subsidiary of GigCapital2; and 

WHEREAS, Holdings, GigCapital2 and Merger Sub desire to amend Schedule 7.06(C) of the BCA as set forth herein. 

AGREEMENT 
 NOW,
THEREFORE, in consideration of the premises and the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 

1.     Recitals. The above recitals are hereby incorporated by reference into this Amendment as if
set forth in full in the body hereof and each Party represents and warrants that, as to it, said recitals are true and accurate. 
 2.
    Amendment. The Parties hereby amend and restate Schedule 7.06(C) of the BCA in its entirety in the form attached hereto as Exhibit A. 

3.     Interpretation. The terms of Section 1.03 of the BCA are hereby incorporated into
this Amendment by reference. 
 4.     BCA Provisions. Except as specifically amended hereunder,
all of the terms and conditions of the BCA remain in full force and effect and this Amendment shall be governed by, and construed and enforced in accordance with, such terms and conditions. In the event of a conflict between the provisions of this
Amendment and the provisions set forth in the BCA, this Amendment shall control. 
 5.
    Counterparts. This Amendment may be executed in two or more counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same agreement. A signed copy of
this Amendment delivered by facsimile, e-mail or other means of electronic transmission shall be deemed to have the same legal effect as delivery of an original signed copy of this Amendment. 

  
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 6.     Applicable Law. This Amendment shall be governed by
and construed in accordance with the Laws of the State of Delaware and without reference to the choice or conflict of law principles (whether of the State of Delaware or any other jurisdiction) that would result in the application of the Laws of a
different jurisdiction. 
 7.     Successors and Assigns. No Party to this Amendment may directly or
indirectly assign any or all of its rights or delegate any or all of its obligations under this Amendment without the express prior written consent of each other Party to this Amendment. This Amendment shall be binding upon and inure to the benefit
of the Parties to this Amendment and their respective successors and permitted assigns. Any attempted assignment in violation of this Section 7 shall be void. 

[Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the Parties hereto have executed this Amendment as of
the day and year first above written. 
  

			
	 GIGCAPITAL2, INC.
  

	By	 	 /s/ Dr. Raluca Dinu

	Name: Dr. Raluca Dinu
	Title: President and Chief Executive Officer
	  
 UPHEALTH MERGER SUB, INC.

 

	By	 	 /s/ Dr. Raluca Dinu

	Name: Dr. Raluca Dinu
	Title: President and Chief Executive Officer
	  
 UPHEALTH HOLDINGS, INC.

 

	By	 	 /s/ Dr. Chirinjeev Kathuria

	Name: Dr. Chirinjeev Kathuria
	Title: Executive Chairman

 [Signature Page to Fourth Amendment to BCA] 

 EXHIBIT A 

SCHEDULE 7.06(C) 

Thrasys Incentive Restricted Stock Units 

1.     Following the Closing and the filing of a registration statement under Form S-8 for the Equity Plan, each of the individuals listed
in the tables below shall, subject to the approval of the UpHealth Board, be issued the number of restricted stock units of GigCapital2 under the Equity Plan as set forth next to such individual’s name in Section 2 below, subject to the vesting
restrictions set forth below; provided, that, an individual’s right to receive any restricted stock units shall be conditioned upon the receipt by GigCapital2 of an agreement in a form reasonably acceptable to GigCapital2 pursuant to which such
individual agrees to waive any right to receive any stock options, restricted stock units or any other equity interests of the Company, the Surviving Corporation, GigCapital2 or any of the Company Subsidiaries and agrees to release all claims
against GigCapital2, the Company, the Surviving Corporation or any of the Company Subsidiaries for any failure by the Company or any of the Company Subsidiaries to issue stock options, restricted stock units or other equity interests of the Company
or any of the Company Subsidiaries. Notwithstanding the foregoing, no provision of this Schedule 7.06(c) shall (a) create any third-party beneficiary or other rights in any employee or former employee (including any beneficiary or
dependent thereof) of GigCapital2, the Company, the Surviving Corporation, any of their respective Affiliates or any other Person other than the parties to this Agreement and their respective successors and permitted assigns, (b) constitute or
create or be deemed to constitute or create an employment agreement or (c) constitute or be deemed to constitute an amendment to any employee benefit plan sponsored or maintained by GigCapital2, the Company, the Surviving Corporation or any of
their respective Affiliates. For the avoidance of doubt, all grants shall be subject to the approval of the UpHealth Board and any restrictions deemed appropriate or necessary by the UpHealth Board. An individual shall be eligible to receive a grant
only if he or she is a service provider to GigCapital2, the Surviving Corporation or any of the Company Subsidiaries as of the date of grant. All grants shall be subject to the terms of the Equity Plan and the form of agreement thereunder. 

2.     Subject to Section 1, following the Closing, GigCapital2 shall grant to the individuals set forth below the number of
restricted stock units of GigCapital2 as set forth next to each such individual’s name, which restricted stock units shall vest into shares of GigCapital2 Common Stock at the earlier of (i) the date that is one year after the Closing Date
of the business combination, (ii) the date on which the last sale price of the common stock equals or exceeds $12.50 per share (as adjusted for stock splits, stock dividends, reorganizations, recapitalizations and the like) for any 20 trading
days within any 30-trading day period commencing at least 90 days after the Closing Date of the business combination, or (iii) the date on which the Company completes a liquidation, merger, stock exchange or other similar transaction that
results in all of the Company’s stockholders having the right to exchange their shares of Common Stock for cash, securities or other property. If an individual set forth below ceases to be a service provider to GigCapital2, the Surviving
Corporation or any of the Company Subsidiaries prior to any vesting date, the unvested portion of the restricted stock units shall be cancelled and surrendered to GigCapital2. 

The Thrasys Incentive Amount that shall be eligible to be granted shall be (a) 31.617% multiplied by (b) 15.1355886% multiplied by (c) the
Adjusted Aggregate Merger/Incentive Amount. 
 The Adjusted Aggregate Merger/Incentive Amount shall be (a) the Aggregate Merger Consideration Value
divided by (b) $10.00. 
  

					
	Name	  	% of the Thrasys Incentive Amount
to be Granted to Individual	 
	 Ramesh Balakrishnan
	  	 	87.802	% 
	 Ranjani Ramakrishna
	  	 	12.198	% 

 In the event that any individual ceases to be a service provider to GigCapital2, the Surviving Corporation or any of the
Company Subsidiaries as of the date of grant, the above percentages will not be reallocated among the remaining individuals.Exhibit 4.3

 

	NUMBER

 ________-	 	(SEE REVERSE SIDE FOR LEGEND) 

THIS WARRANT WILL BE VOID IF NOT EXERCISED PRIOR TO THE 

EXPIRATION DATE (DEFINED BELOW)	 	WARRANTS

NOVUS CAPITAL
CORPORATION

CUSIP 67012U1161

WARRANT

 

THIS CERTIFIES THAT, for value received

is the registered holder of a warrant or warrants
(the “Warrant(s)”) of Novus Capital Corporation, a Delaware corporation (the “Company”), expiring
at 5:00 p.m., New York City time, on the five year anniversary of the Company’s completion of an initial merger, share exchange,
asset acquisition, stock purchase, recapitalization, reorganization or other similar business combination with one or more businesses
or entities (a “Business Combination”), to purchase one fully paid and non-assessable share of common stock, par value
$0.0001 per share (“Shares”), of the Company for each whole Warrant evidenced by this Warrant Certificate. The Warrant
entitles the holder thereof to purchase from the Company, commencing on the later of (a) 30 days after the Company’s completion
of an initial Business Combination, and (b) 12 months from the closing of the Company’s initial public offering (“IPO”),
such number of Shares of the Company at the Warrant Price (as defined below), upon surrender of this Warrant Certificate and payment
of the Warrant Price at the office or agency of Continental Stock Transfer & Trust Company (the “Warrant Agent”),
but only subject to the conditions set forth herein and in the Warrant Agreement between the Company and Continental Stock Transfer &
Trust Company. In no event will the Company be required to net cash settle any warrant exercise. The term “Warrant Price”
as used in this Warrant Certificate refers to the price per Share at which Shares may be purchased at the time the Warrant is exercised.
The initial Warrant Price per Share is equal to $11.50 per share. The Warrant Agreement provides that upon the occurrence of certain
events the Warrant Price, the Redemption Trigger Price (as defined below), and the number of Shares purchasable hereunder, set forth
on the face hereof, may, subject to certain conditions, be adjusted.

 

No fraction of a Share will
be issued upon any exercise of a Warrant. If the holder of a Warrant would be entitled to receive a fraction of a Share upon any exercise
of a Warrant, the Company shall, upon such exercise, round up to the nearest whole number the number of Shares to be issued to such holder.

 

Upon any exercise of the
Warrant for less than the total number of full Shares provided for herein, there shall be issued to the registered holder hereof or the
registered holder’s assignee a new Warrant Certificate covering the number of Shares for which the Warrant has not been exercised.

 

Warrant Certificates, when
surrendered at the office or agency of the Warrant Agent by the registered holder in person or by attorney duly authorized in writing,
may be exchanged in the manner and subject to the limitations provided in the Warrant Agreement, but without payment of any service charge,
for another Warrant Certificate or Warrant Certificates of like tenor and evidencing in the aggregate a like number of Warrants.

 

Upon due presentment for
registration of transfer of the Warrant Certificate at the office or agency of the Warrant Agent, a new Warrant Certificate or Warrant
Certificates of like tenor and evidencing in the aggregate a like number of Warrants shall be issued to the transferee in exchange for
this Warrant Certificate, subject to the limitations provided in the Warrant Agreement, without charge except for any applicable tax
or other governmental charge.

 

The Company and the Warrant
Agent may deem and treat the registered holder as the absolute owner of this Warrant Certificate (notwithstanding any notation of ownership
or other writing hereon made by anyone), for the purpose of any exercise hereof, of any distribution to the registered holder, and for
all other purposes, and neither the Company nor the Warrant Agent shall be affected by any notice to the contrary.

 

This Warrant does not entitle
the registered holder to any of the rights of a stockholder of the Company.

 

The Company reserves the
right to call the Warrant at any time prior to its exercise with a notice of call in writing to the holders of record of the Warrant,
giving at least 30 days’ notice of such call, at any time while the Warrant is exercisable, if the last sale price of the Shares
has been at least $18.00 per share (the “Redemption Trigger Price”) on each of 20 trading days within any 30 trading
day period (the “30-day trading period”) ending on the third business day prior to the date on which notice of such
call is given and if, and only if, there is a current registration statement in effect with respect to the Shares underlying the Warrants
commencing five business days prior to the 30-day trading period and continuing each day thereafter until the date of redemption. The
call price of the Warrants is to be $0.01 per Warrant. Any Warrant either not exercised or tendered back to the Company by the end of
the date specified in the notice of call shall be canceled on the books of the Company and have no further value except for the $0.01
call price.

 

	By	 
	President	Secretary

 

     

     

    

 

SUBSCRIPTION FORM

 

To Be Executed by the Registered Holder in Order
to Exercise Warrants

The undersigned Registered Holder irrevocably
elects to exercise ______________ Warrants represented by this Warrant Certificate, and to purchase the Common Stock issuable upon the
exercise of such Warrants, and requests that Certificates for such shares shall be issued in the name of

	(PLEASE
    TYPE OR PRINT NAME AND ADDRESS)
	 
	 
	(SOCIAL
    SECURITY OR TAX IDENTIFICATION NUMBER)

 

	and
    be delivered to 	 	 
	(PLEASE
    PRINT OR TYPE NAME AND ADDRESS)
	and,
    if such number of Warrants shall not be all the Warrants evidenced by this Warrant Certificate, that a new Warrant Certificate for
    the balance of such Warrants be registered in the name of, and delivered to, the Registered Holder at the address stated below:

 

	Dated:	 	 	 
	 	 	 	(SIGNATURE)
	 	 	 	(ADDRESS)
	 	 	 	(TAX
    IDENTIFICATION NUMBER)

 

     

     

    

 

ASSIGNMENT

 

To Be Executed by the Registered Holder in Order
to Assign Warrants

For Value Received, _______________________ hereby
sell, assign, and transfer unto

 

	(PLEASE
    TYPE OR PRINT NAME AND ADDRESS)
	 
	 
	(SOCIAL
    SECURITY OR TAX IDENTIFICATION NUMBER)

 

	and
    be delivered to 	 	 
	(PLEASE
    PRINT OR TYPE NAME AND ADDRESS)

______________________ of the Warrants represented
by this Warrant Certificate, and hereby irrevocably constitute and appoint _________________________________ Attorney to transfer this
Warrant Certificate on the books of the Company, with full power of substitution in the premises.

	Dated: _________________________	_________________________________
	 	(SIGNATURE)

The signature
to the assignment of the Subscription Form must correspond to the name written upon the face of this Warrant Certificate in every particular,
without alteration or enlargement or any change whatsoever, and must be guaranteed by a commercial bank or trust company or a member
firm of the NYSE American, Nasdaq, New York Stock Exchange, Pacific Stock Exchange, or Chicago Stock Exchange.

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