Document:

Mutual Termination Agreement

EXHIBIT 10.22

Mutual Termination Agreement

("Agreement")

with regard to the Master Distribution and Off Take Agreement

("Master Distribution Agreement")

between

Integrated Surgical Systems, Inc.

1850 Research Park Drive

Davis, CA 95616

USA

acting for itself as well as on behalf of ISS B.V., The Netherlands

("ISS")

and

SPARK 1st Vision GmbH & Co. KG
Große Bockenheimer Str. 5) 60313 Frankfurt

Germany

("Distributor")

both hereinafter individually and jointly referred to as "Party" or "Parties"- 

with regard to the mutual termination of the above Master Distribution Agreement.

WHEREAS, ISS is a prestigious medical robotics company and the world leader in image-directed, semi-autonomous software and robotic products for surgical applications; and

WHEREAS, ISS has entered into the Master Distribution Agreement with the Distributor with regard to the marketing of ISS services and products on November 12, 1999; and

WHEREAS, the Parties deem it advantageous to both Parties to mutually terminate the Master Distribution Agreement as set forth herein,

NOW, THEREFORE, the Parties agree as follows:

	In consideration of the release of Distributor from its payment, off-take and other obligations under the Master Distribution Agreement. the Distributor undertakes to pay the sum of DEM 2 million net and without deduction to an
account to be designated by ISS until May 11, 2000 at the latest. Such payment shall be in lieu of and in full satisfaction of any outstanding invoices and claims regarding license payments, off-take obligations and reimbursement of sales, marketing and
other expenses and cost obligations of the Distributor under the Master Distribution Agreement, currently amounting to EUR 835.390.  Upon payment of such amount of DEM 2 million, the Distributor shall be released from and discharged from all payment and
off-take obligations under the Master Distribution Agreement and the Master Distribution Agreement including any changes thereof and amendments thereto, if any, shall be mutually terminated in its entirety. ISS shall invoice SPARK accordingly.

	In consideration of the release under 2 above, the Distributor herewith waives any claims and rights it may have with regard to any commission claims it may have against ISS under the Master Distribution Agreement, irrespective of
whether such claims have already become due and payable or not.

	As of May 1, 2000 the Distributor sha1l refrain from any further marketing activities as set forth in the Master Distribution Agreement and ISS shall be free to organize and pursue any further marketing activities with regard to
any products or services of ISS or any subsidiaries of ISS as it deems appropriate. The Distributor shall reasonably assist ISS and any customers so as to ascertain a smooth transition of the services previously rendered by the Distributor towards any
customers to ISS at its own cast. Such obligation shall automatically expire upon June 30, 2000, unless the Parties agree upon an extension in writing. The Distributor shall in due course change its firm name to any other firm name that will not create
any misunderstanding or confusion.

	As of May 1, 2000, the Distributor shall be released from all obligations with regard to any employees of ISS B.V. The Netherlands and ISS shall indemnify and hold harmless the Distributor from all claims of such employees
or third parties related thereto.

	The Parties agree that except where expressly set forth otherwise herein, upon payment of the sum of 2 million DEM as above all mutual rights, licenses, obligations and liabilities under the Master Distribution Agreement shall
automatically terminate. The parties expressly waive any rights or claims that they may have toward each other under the Master Distribution Agreement, whether oral or in writing, including but not limited to warranty claims, and release each other from
any obligations or liabilities in connection therewith.

	This Agreement shall be governed by the laws of Germany without regard to its conflict of law provisions. Exclusive place of jurisdiction shall be Frankfurt am Main, Germany.

	This Agreement constitutes the entire understanding and agreement of the parties with regard to the subject matter hereof and supersedes all prior agreements, negotiations, correspondence and understanding between the Parties.

	Any changes to or amendments to this Agreement shall require written form. This Agreement may not be assigned by either Party without the prior written consent of the other Party.

	In case any provision of this Agreement is either invalid or not enforceable the validity of the remaining provisions of this Agreement shall not be affected thereby. The Parties undertake to replace the invalid or unenforceable
provision by a provision coming as close as possible to the intended commercial purpose of the replaced provision.

 
Davis, this 9th day of May, 2000

_______________________

ISS

 
Frankfurt, this 9th day of May, 2000

_______________________

DISTRIBUTORILTAG International Licensing Holding S

EXHIBIT 10.23

ILTAG International Licensing Holding S.A.L.

Adnan Al-Hakim Street, Jnah District

Beirut, Lebanon

Personal Undertaking 

("Undertaking")

towards

Integrated Surgical Systems, Inc.

1850 Research Park Drive

Davis, CA 95616

USA

WHEREAS, the undersigned has purchased a warrant to purchase 5.850.000 shares of Common Stock of Integrated Surgical Systems, Inc., Davis, CA, USA ("ISS") on December 14,1999 (the "Warrant"); and

WHEREAS, in view of the fact that the undersigned has declined to participate in the next round of financing in ISS; and

NOW, THEREFORE, the undersigned herewith irrevocably makes the following Undertaking:
1. The undersigned herewith irrevocably and unconditionally waives any rights and claims he may have under the Warrant with regard to the purchase of an aggregate of 2.850.000 shares of Common Stock of ISS. The undersigned directs ISS to cancel
the Warrant delivered with this Undertaking as to 2.850.000 shares and to reissue to the undersigned until June 30, 2000 at the latest, new warrants ("New Warrants") to purchase the remaining 3 million shares as follows:

	one warrant to purchase 2 million shares; 
	four warrants, each to purchase 250.000 shares.

The New Warrants shall have the same terms and conditions as the Warrant except as

set forth in para 2. below.
2.The undersigned further irrevocably undertakes to exercise his right to purchase the following amount of shares of Common Stock of ISS under the New Warrants at any time prior to the respective following dates at a purchase price of 1.02656 USD
provided, that the quoted 5-day-average NASDAQ stock price for ISS Common Stock is at least 1.03 USD per share of Common Stock prior to exercise of the New Warrants:

By not later than September 5, 2000 - 250.000 shares of Common Stock

By not later than October 5,2000 - an additional 250.000 shares of Common Stock

By not later than November 5, 2000 - an additional 250.000 shares of Common Stock 

By not later than December 5, 2000 - an additional 250.000 shares of Common Stock.
Any New Warrants that are to be exercised as above shall automatically expire in case they are not exercised upon the respective above dates.

With regard to the balance of 2.000.000 shares of Common Stock of ISS the terms and conditions of the New Warrants shall fully apply and the undersigned shall not be subject to any further restrictions or obligations except those set forth in the New
Warrants.

3. This Undertaking shall be subject to German law without regard to its conflict of laws provisions. Exclusive place of jurisdiction shall be Zurich, Switzerland. This Undertaking constitutes the entire Undertaking of the undersigned regarding
the subject matter hereof.

Beirut, May 30, 2000

ILTAGUrs Wettstein

EXHIBIT 10.24

Urs Wettstein

Seedammstrasse 58

CH-8640 Hurden

Personal Undertaking 

("Undertaking")

towards

Integrated Surgical Systems, Inc.

1850 Research Park Drive

Davis, CA 95616

USA

WHEREAS, the undersigned has purchased a warrant to purchase 2.925.000 shares of Common Stock of Integrated Surgical Systems, Inc., Davis, CA, USA ("ISS") on December 14,1999 (the "Warrant"); and

WHEREAS, in view of the fact that the undersigned has declined to participate in the next round of financing in ISS; and

WHEREAS, the undersigned intends to resign from the Board of ISS effective June 10, 2000 and will reduce his personal attention and contributions to ISS to that of a mere financial investor;

NOW, THEREFORE, the undersigned herewith irrevocably makes the following Undertaking:

	The undersigned herewith irrevocably and unconditionally waives any rights and claims he may have under the Warrant with regard to the purchase of an aggregate of 1.425.000 shares of Common Stock of ISS. The undersigned directs ISS to cancel the
Warrant delivered with this Undertaking as to 1.425.000 shares and to reissue to the undersigned until June 30, 2000 at the latest, new warrants ("New Warrants") to purchase the remaining 1.5 million shares as follows:

 - one warrant to purchase 1 million shares;

- four warrants, each to purchase 125.000 shares.

The New Warrants shall have the same terms and conditions as the Warrant except as

set forth in para 2. below.
2.  The undersigned further irrevocably undertakes to exercise his right to purchase the following amount of shares of Common Stock of ISS under the New Warrants at any time prior to the respective following dates at a purchase price of 1.02656 USD
provided, that the quoted 5-day-average NASDAQ stock price for ISS Common Stock is at least 1.03 USD per share of Common Stock prior to exercise of the New Warrants:

By not later than September 5, 2000 - 125.000 shares of Common Stock

By not later than October 5,2000 - an additional 125.000 shares of Common Stock

By not later than November 5, 2000 - an additional 125.000 shares of Common Stock 

By not later than December 5, 2000 - an additional 125.000 shares of Common Stock.
Any New Warrants that are to be exercised as above shall automatically expire in case they are not exercised upon the respective above dates.

With regard to the balance of 1.000.000 shares of Common Stock of ISS the terms and conditions of the New Warrants shall fully apply and the undersigned shall not be subject to any further restrictions or obligations except those set forth in the New
Warrants.

3.   This Undertaking shall be subject to German law without regard to its conflict of laws provisions. Exclusive place of jurisdiction shall be Zurich, Switzerland. This Undertaking constitutes the entire Undertaking of the undersigned regarding
the subject matter hereof.

 

Hurden, May 21, 2000

Urs Wettstein

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