Document:

Exhibit
10.1

    

     

    Platinum-Montaur
Life Sciences, LLC

    152 West
57th
Street

    New York,
New York 10019

    

    

                                                                    March
31, 2009

    

    Neoprobe
Corporation

    425 Metro
Place North, Suite 300

    Dublin,
Ohio 43017

    

    Ladies
and Gentlemen:

    

               Reference
is made to (i) the 10% Series A Senior Secured Convertible Promissory Note in
the principal amount of $7,000,000 (the “Series A Note”) issued by Neoprobe
Corporation (“Neoprobe”) to Platinum-Montaur Life Sciences, LLC (“Platinum”),
(ii) the 10% Series B Senior Secured Convertible Promissory Note in the initial
principal amount of $3,000,000 (the “Series B Note” and, together with the
Series A Note, the “Notes”) issued by Neoprobe to Platinum, (iii) the 8%
Cumulative Convertible Preferred Stock (the “Preferred Stock”) issued by
Neoprobe to Platinum, (iv) the Series X Warrant to Purchase Shares of Common
Stock (the “Series X Warrant”) issued by Neoprobe to Platinum and (v) the Series
Y Warrant to Purchase Shares of Common Stock (the “Series Y Warrant”) issued by
Neoprobe to Platinum.

    

               Pursuant
to and in accordance with Section 1.2 of the Notes, Neoprobe is permitted to pay
interest on the Notes in shares of its Common Stock (“Interest Shares”), at a
valuation determined by reference to 90% of the average VWAP (as defined in the
Notes) for the five Trading Days (as defined in the Notes) immediately preceding
the date of payment.  Neoprobe is permitted to pay dividends on the
Preferred Stock in shares of its Common Stock (“Dividend Shares” and, together
with the Interest Shares, the “Payment Shares”).

    

               You
have asked Platinum to waive certain conversion or exercise price adjustments
under the Preferred Stock, the Series X Warrant and the Series Y Warrant that
may result from the issuance and payment of the Payment Shares.  You
have also asked Platinum to extend to Neoprobe a two business day “grace” period
for the delivery of certificates representing the Payment Shares.

    

               Platinum
hereby agrees that, for so long as no Event of Default (as defined in the Notes)
shall have occurred, (i) Platinum will be deemed to have waived any adjustment
to the conversion price or the exercise price under the Preferred Stock, the
Series X Warrant and the Series Y Warrant, as applicable, that would have
otherwise been made as a result of the issuance and payment of the Payment
Shares; provided that such waiver is effective only if the valuation of the
Payment Shares under Section 1.2 of the Notes (i.e., 90% of the trailing five
Trading Day average VWAP), assuming for purposes of this calculation that such
Payment Shares are paid pursuant to the Notes, is more than $0.40 per share, and
(ii) the physical delivery of a certificate representing the Payment Shares at
any time up to two business days after the relevant interest or dividend payment
date shall be deemed timely delivered.

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

               By
its execution below, Neoprobe agrees (i) that any shares of Common Stock
delivered as Dividend Shares shall, notwithstanding any provision of the
Certificate of Designations, Voting Power, Preferences, Limitations,
Restrictions and Relative Rights (the “Certificate of Designations”) of the
Preferred Stock to the contrary, be valued by reference to 90% of the average
VWAP for the five Trading Days immediately preceding the date of payment,
including the dividend payment to be made by Neoprobe on the date hereof, and
(ii) the Certificate of Designations shall amended within 30 days of the date
hereof to reflect such a revised valuation for all future payment of Dividend
Shares.  

    

    

    
      
        
          
            
              
                
                  
                    
                      
                        	 
      	
                                Very
      truly yours,

                              	 
	 
      	 
      	 
      	 
	 
      	 
      	 
      	 
	 
      	
                                Platinum-Montaur
      Life Sciences, LLC

                              
	 
      	 
      	 
      	 
	 
      	 
      	 
      	 
	 
      	
                                By:

                              	
                                /s/
      Michael Goldberg

                              	 
	 
      	
                                Name:
      Michael Goldberg

                              
	 
      	
                                Title:
      Portfolio Manager

                              
	 
      	 
      	 
      	 

                      

                    

                  

                

              

            

          

        

      

    

    

    Accepted
and Agreed to this

    31st day
of March, 2009 by

    

    

    
      
        
          
            
              
                	
                        Neoprobe
      Corporation

                      	 
      
	 
      	 	 
      
	 
      	 	 
      
	
                        By:

                      	      
                        /s/
      Brent L. Larson

                      	
                         

                      
	
                        Name:
      Brent L. Larson

                      	 
      
	
                        Title:
      VP Finance/ CFO20-F

                                                                     EXHIBIT 4.5

                                NICE SYSTEMS LTD.

                             2003 STOCK OPTION PLAN

     This 2003 Stock Option Plan of NICE Systems Ltd. (amending and restating
the Company's prior employee stock option plan) was adopted by the Board of
Directors of the Company on October 20, 2003, subject to the approval of the
Company's shareholders which was obtained at the Company's Annual General
Meeting of Shareholders on December 2, 2003. This 2003 Stock Option Plan amends
and restates the Company's 1995 Employee Stock Option Plan (as so amended and
restated, the "2003 Stock Option Plan" or the "Plan"). The Plan was further
amended by the Board of Directors of the Company on August 2, 2005 and on
November 6, 2006, subject to the approval of the Company's shareholders, which
was obtained at the Company's Annual General Meeting of Shareholders on
September 28, 2005 and December 21, 2006, respectively, and thereafter on July
31, 2007.

     1. PURPOSE; ADMINISTRATION

          (a) PURPOSE. The Plan is hereby continued for the purpose of providing
     to certain employees, directors and officers of the Company and its
     subsidiary corporations (collectively referred to as the "Company"), and
     any present or future parent and/or subsidiary corporations of any such
     corporation (all of whom along with the Company being individually referred
     to as a "Participating Company" and collectively referred to as the
     "Participating Company Group"), in the form of options ("Options") to
     purchase ordinary shares, par value NIS 1.00 per share, of NICE Systems
     Ltd. (the "Ordinary Shares"), to further the advancement of the
     Participating Company Group and its businesses.

          (b) ADMINISTRATION. The Plan shall be administered by the Board of
     Directors of the Company (the "Board") and/or by a duly appointed committee
     of the Board having such powers as shall be specified by the Board. Any
     subsequent references herein to the Board shall also mean the committee if
     such committee has been appointed and, unless the powers of the committee
     have been specifically limited, the committee shall have all of the powers
     of the Board granted herein except for the power to terminate or amend the
     Plan at any time, subject to the terms of the Plan and any applicable
     limitations imposed by law. The appointment of the Committee and the
     administration of the Plan by the Committee shall be in accordance with any
     applicable requirements of the Israeli Companies Law, Israeli tax law and
     any applicable non-Israeli tax, securities and other laws. Subject to the
     provisions of the Plan, the Board shall be authorized, from time to time,
     to: (i) determine the employees, directors and officers of the
     Participating Company Group to whom an Option or Options shall be granted
     ("Optionees"); (ii) determine the number of Ordinary Shares to be made
     subject to any Option; (iii) determine the date of grant of an Option; (iv)
     determine the type of Option to be granted; and (v) make any other
     determination deemed by the Board to be necessary or desirable for the
     administration of the Plan and any Option granted under the Plan. All
     questions of interpretation of the Plan or of any Option shall be
     determined by the Board, and such determinations shall be final and binding
     upon the Participating Company Group, each Optionee and their respective
     successors and assigns.

     2. ADDITIONAL TERMS FOR SPECIFIC JURISDICTIONS; NON-QUALIFIED OPTIONS.

          (a) The Board may, from time to time, approve (and amend or modify
     from time to time) appendices setting forth any special requirements that
     are applicable to options granted to recipients in the various
     jurisdictions in which options may be granted under the Plan pursuant to
     applicable local laws and regulations, all of which appendices (as amended
     or modified from time to time) shall constitute an integral part of the
     Plan. Appendix "A" hereto attached sets forth the provisions applicable to
     options which may be granted to United States participants in the Plan.

          (b) With respect to all Optionees, an Option may be a "non-qualified
     stock option" (an option not intended to be an incentive stock option) or
     an option of a similar type as provided under the laws of any applicable
     jurisdictions.

     3. ELIGIBILITY. Options may be granted only to directors, officers and
other employees of the Participating Company Group. The Board shall, in its sole
discretion, determine which eligible persons shall be granted Options. An
Optionee may, if otherwise eligible, be granted additional Options.

     4. SHARES SUBJECT TO OPTION. Options shall be options for the purchase of
Ordinary Shares or ADRs (as defined below), subject to adjustment as provided in
paragraph 9 below. Subject to adjustment as provided in paragraph 9 below, with
respect to calendar year 2003, the maximum number of Ordinary Shares that may be
issued pursuant to Options granted under the Plan shall be 500,000; provided
that such maximum number of Ordinary Shares shall increase each year after
calendar year 2003 by the lesser of (x) 300,000 Ordinary Shares or (y) two
percent (2%) of the total number of outstanding Ordinary Shares as of December
31st of the immediately preceding calendar year. As of May 30, 2006, the 500,000
and 300,000 Ordinary Shares aforementioned are adjusted to 1,000,000 and 600,000
Ordinary Shares, respectively, to reflect a two-for-one stock split.

                                       2

Subject to adjustment as provided in paragraph 9 below, pursuant to the
shareholders resolution of September 28, 2005, the number of Ordinary Shares
that may be issued pursuant to Options under the Plan is increased by 531,056,
with an annual addition of 250,000 Ordinary Shares from calendar year 2006
through calendar year 2009, except that as of May 30, 2006, the 531,056 and
250,000 Ordinary Shares aforementioned are adjusted to 1,062,112 and 500,000
Ordinary Shares, respectively, to reflect a two-for-one stock split.

In addition, and subject to adjustment as provided in paragraph 9 below,
pursuant to the shareholders resolution of December 21, 2006, the number of
Ordinary Shares reserved for issuance pursuant to Options under the Plan is
further increased by 1,300,000 shares.

Notwithstanding the foregoing, an Optionee may elect at the time of exercise of
an Option to purchase, in lieu of Ordinary Shares, an equal number of the
Company's American Depositary Receipts ("ADRs"), each of which represents one
American Depositary Share which, in turn, represents one Ordinary Share. Options
may not be exercised for a combination of Ordinary Shares and ADRs.

     5. TIME FOR GRANTING OPTIONS. The Plan shall continue until terminated by
the Board or until all of the Ordinary Shares reserved for issuance under the
Plan have been issued, whichever shall first occur.

     6. TERMS, CONDITIONS AND FORM OF OPTIONS. Subject to the provisions of the
Plan, the Board shall determine for each Option (which need not be identical)
the number of Ordinary Shares for which the Option shall be granted, the
exercise price of the Option, the exercisability of the Option, and all other
terms and conditions of the Option not inconsistent with the Plan. Options
granted pursuant to the Plan shall be evidenced by written agreements specifying
the number of Ordinary Shares covered thereby, in such form as the Board shall
from time to time establish, and shall comply with and be subject to the
following terms and conditions:

          (a) EXERCISE PRICE. The exercise price per share for each Option shall
     be equal to the closing sales price of one ADR as quoted on the NASDAQ
     market on the most recent date prior to the date of the resolution of the
     Board to grant the Option (such date, the "Date of Grant") for which a
     closing sales price was quoted.

                                       3

          (b) EXERCISE PERIOD OF OPTIONS. Unless otherwise determined by the
     Board as of the Date of Grant, each Option granted under the Plan shall
     have a term of six years, commencing on the Date of Grant.

          (c) VESTING/EXERCISABILITY OF OPTIONS. Unless otherwise determined by
     the Board, Options granted under the Plan shall become vested and
     exercisable with respect to twenty five percent (25%) of the Ordinary
     Shares covered thereby on the first anniversary of the Date of Grant, and
     the remainder, once every quarter thereafter (6.25% per quarter), provided
     that the Optionee is employed by or providing services to the Participating
     Company Group as of each such vesting date.

          (d) PAYMENT OF EXERCISE PRICE. Payment of the exercise price for the
     number of Ordinary Shares (or ADRs) being purchased pursuant to any Option
     shall be made (i) in cash, by certified check or money order, or such cash
     equivalent as is approved by the Board or any committee thereof, (ii) by
     the assignment of the proceeds of a sale of some or all of the Ordinary
     Shares (or ADRs) being acquired upon the exercise of an Option (including,
     without limitation, through an exercise complying with the provisions of
     Regulation T as promulgated from time to time by the Board of Governors of
     the Federal Reserve System), or (iii) by a combination thereof. The Board
     may at any time or from time to time, by any permissible means, grant
     Options which do not permit all of the foregoing forms of consideration to
     be used in payment of the exercise price and/or which otherwise restrict
     one or more forms of consideration.

          (e) MANNER OF EXERCISE. Exercise of an Option shall be effected by way
     of a notice of exercise which shall be in a form determined by the Company
     from time to time (the "Exercise Notice"). The Exercise Notice shall be
     delivered by the Optionee to the offices of the Company on one of the
     Company's days of business and shall be addressed to the Company. Payment
     in full of the exercise price of the Option (or portion thereof) being
     exercised, unless such Option exercise is to be effected pursuant to
     paragraph 6(d)(ii) of the Plan. Once delivered to the Company the Exercise
     Notice shall be irrevocable.

          (f) The Company reserves, at any and all times, the right, in the
     Company's sole and absolute discretion, to establish, decline to approve
     and/or terminate any program and/or procedures for the exercise of Options
     by means of an assignment of the proceeds of a sale of some or all of the
     Ordinary Shares to be acquired upon such exercise.

                                       4

     7. TERMINATION OF EMPLOYMENT OR SERVICES. In the event that an Optionee's
employment with, or services to, the Participating Company Group is terminated,
the provisions of this paragraph 7 shall apply to Options held by such Optionee.
For purposes of the Plan, "Termination Date" shall mean the effective date on
which an Optionee's employment or services to the Participating Company Group is
terminated. The transfer of an Optionee from one member of the Participating
Company Group to another shall not be deemed a termination of employment or
services.

          (a) In the event that the Optionee's employment with or service to the
     Participating Company Group is terminated (i) for Cause (as defined below)
     or (ii) under circumstances under which the Optionee is not entitled to
     severance pay pursuant to any local law or regulation, any non-vested
     Option, then held by such Optionee shall immediately expire and be
     forfeited as of the Termination Date. For purposes of the Plan, unless
     otherwise defined in the agreement evidencing a particular Option or an
     employment agreement between the Company and the relevant individual,
     "Cause" means an individual's (i) intentional failure to perform reasonably
     assigned duties, (ii) dishonesty or willful misconduct in the performance
     of duties, (iii) involvement in a transaction in connection with the
     performance of duties to the Company which transaction is adverse to the
     interests of the Company and which is engaged in for personal profit, (iv)
     willful violation of any law, rule or regulation in connection with the
     performance of duties (other than traffic violations or similar offenses),
     or (v) the commission of an act of fraud or intentional misappropriation or
     conversion of assets or opportunities of the Company.

          (b) In the event that an Optionee's employment with or service to the
     Participating Company Group is terminated (i) by reason of an Optionee's
     disability, the portion of any Option held by such Optionee as of the
     Termination Date and which is not vested and exercisable as of the
     Termination Date, shall immediately expire and be forfeited as of the
     Termination Date (ii) by reason of death of an Optionee who is NOT a
     director, the portion of any Option held by such Optionee as of the
     Termination Date and which is not vested and exercisable as of the
     Termination Date, shall be accelerated and become immediately vested and
     exercisable as of the Termination Date and shall remain exercisable by the
     Optionee (or such Optionee's heirs, distributees or estate, as the case may
     be) until the first anniversary of such Termination Date, after which
     period it shall expire and be forfeited (to the extent not previously
     exercised), (iii) by reason of death of an Optionee who is a director, the
     portion of any Option held by such Optionee as of the Termination Date and
     which is not vested and exercisable as of the Termination Date, shall
     immediately expire and be forfeited as of the Termination Date, (iii) and
     (iv) by reason of death or disability of any Optionee, the portion of any
     Option which is vested and exercisable as of the Termination Date shall
     remain exercisable by the Optionee (or such Optionee's heirs, distributees
     or estate, as the case may be) until the first anniversary of such
     Termination Date, after which period it shall expire and be forfeited. For
     purposes of the Plan, "disability" shall mean the inability of an Optionee
     to fulfill his or her position as a result of injury and/or disease for a
     period of at least six consecutive months.

                                       5

          (c) In the event that the Optionee's employment with or service to the
     Participating Group is terminated other than as set forth in subparagraphs
     (a) or (b) above, with respect to any Option then held by such Optionee,
     (i) the portion of any such Option which is not vested and exercisable as
     of the Termination Date shall immediately expire and be forfeited as of the
     Termination Date and (ii) the portion of any such Option which is vested
     and exercisable as of the Termination Date shall remain exercisable in
     accordance with the terms of the Plan and the applicable Option agreement
     for a period of 90 days following the Termination Date, after which date it
     shall expire and be forfeited.

     8. CHANGE IN CONTROL OF THE COMPANY. In the event of a Change in Control
(as defined below), the Board shall have the discretion to:

          (a) accelerate the vesting and exercisability of an Option; or

          (b) determine that an Option be replaced by or converted into an
     equivalent option in the resulting entity.

                                       6

For purposes of the Plan, a "Change in Control" shall mean the first to occur of
the following:

          (i) any Person (within the meaning of Section 3(a)(9) of the U.S.
     Exchange Act of 1934, as amended (the "Exchange Act"), as modified and used
     in Sections 13(d) and 14(d) thereof, except that such term shall not
     include (A) the Company or any of its subsidiaries, (B) a trustee or other
     fiduciary holding securities under an employee benefit plan of the Company
     or any of its affiliates, (C) an underwriter temporarily holding securities
     pursuant to an offering of such securities, or (D) a corporation owned,
     directly or indirectly, by the shareholders of the Company in substantially
     the same proportions as their ownership of Ordinary Shares of the Company,
     is or becomes the "beneficial owner" (within the meaning set forth in Rule
     13d-3 under the Exchange Act), directly or indirectly, of securities of the
     Company (not including the securities beneficially owned by such Person any
     securities acquired directly from the Company or its affiliates)
     representing 25% or more of the combined voting power of the Company's then
     outstanding securities, excluding any Person who becomes such a beneficial
     owner in connection with a transaction described in clause (A) of paragraph
     (iii) below; or

          (ii) the following individuals cease for any reason to constitute a
     majority of the number of directors then serving: individuals who, on the
     date hereof, constitute the Board and any new director (other than a
     director whose initial assumption of office is in connection with an actual
     or threatened election contest, including but not limited to a consent
     solicitation, relating to the election of directors of the Company) whose
     appointment or election by the Board or nomination for election by the
     Company's shareholders was approved or recommended by a vote of at least
     two-thirds (2/3) of the directors then still in office who either were
     directors on the date hereof or whose appointment, election or nomination
     for election was previously so approved or recommended; or

          (iii) there is consummated a merger or consolidation of the Company or
     any direct or indirect subsidiary of the Company with any other
     corporation, other than (A) a merger or consolidation which would result in
     the voting securities of the Company outstanding immediately prior to such
     merger or consolidation continuing to represent (either by remaining
     outstanding or by being converted into voting securities of the surviving
     entity or any parent thereof), at least 50% of the combined voting power of
     the securities of the Company or such surviving entity or any parent
     thereof outstanding immediately after such merger or consolidation, or (B)
     a merger or consolidation effected to implement a recapitalization of the
     Company (or similar transaction) in which no Person is or becomes the
     beneficial owner, directly or indirectly, of securities of the Company (not
     including in the securities beneficially owned by such Person any
     securities acquired directly from the Company or its affiliates)
     representing 25% or more of the combined voting power of the Company's then
     outstanding securities; or

                                       7

          (iv) the shareholders of the Company approve a plan of complete
     liquidation or dissolution of the Company or there is consummated an
     agreement for the sale or disposition by the Company of all or
     substantially all of the Company's assets, other than a sale or disposition
     by the Company of all or substantially all of the Company's assets to an
     entity, at least 25% of the combined voting power of the voting securities
     of which are owned by shareholders of the Company in substantially the same
     proportions as their ownership of the Company immediately prior to such
     sale.

     9. EFFECT OF CHANGE IN SHARES SUBJECT TO PLAN. In the event that the Board
determines that any dividend or other distribution (whether in the form of cash,
shares or other property), recapitalization, share split, reverse share split,
reorganization, merger, consolidation, spin-off, combination, repurchase, or
share exchange, or other similar corporate transaction or event, affects the
Ordinary Shares such that an adjustment is appropriate in order to prevent
dilution or enlargement of the rights of Optionees under the Plan, then the
Board shall make such equitable changes or adjustments as it deems necessary or
appropriate to any or all of (i) the number and kind of Ordinary Shares or other
securities which may thereafter be issued in connection with Options, (ii) the
number and kind of Ordinary Shares or other securities issued or issuable in
respect of outstanding Options, and (iii) the exercise price of any Option. The
Board activities and determinations required under this section may not be
delegated or assigned to the Committee.

     10. WITHHOLDING; OTHER TAXES; INFORMATION. The Company may, in its
discretion, require that, prior to the delivery of a certificate or certificates
representing Ordinary Shares or ADRs, the Optionee: (a) pay in the form of cash
or certified check or money order to the Company any amount as the Company
determines that it is required to withhold under applicable national, state or
local tax laws in respect of the exercise of an Option or the transfer of
Ordinary Shares, which amounts may, in the Company's discretion and subject to
applicable law, in the alternative be withheld from the Optionee's salary, wages
or other compensation payments; (b) agree to be responsible for, and indemnify
the Company from and against, any claim for payment of any other tax or duty
that may become payable in connection with the exercise of an Option or the
transfer of Ordinary Shares, which amounts may, in the Company's discretion and
subject to applicable law, in the alternative be withheld from the Optionee's
salary, wages or other compensation payments; and (c) agree to, if requested at
any time by the Company, provide to the Company within 10 calendar days of such
request, any information regarding the transfer or other disposition of Ordinary
Shares reasonably required by the Company in order for the Company to comply
with applicable local laws and regulations or obtain any benefits thereunder.

                                       8

     11. PROVISION OF INFORMATION. Each Optionee shall be given access to
information concerning the Company equivalent to that information generally made
available to the Company's shareholders.

     12. OPTIONS NON-TRANSFERABLE; LIMITATIONS ON TRANSFERS OF ADRS AND ORDINARY
SHARES. Unless otherwise provided by the Board, during the lifetime of the
Optionee, the Option shall be exercisable only by the Optionee, and no Option
shall be assignable or transferable by the Optionee, except by will or by the
laws of descent and distribution. Any ADRs or Ordinary Shares acquired upon
exercise of Options shall be transferable only in accordance with applicable
securities and other local laws, and may be subject to substantial statutory or
regulatory restrictions on transfer except to the extent exemptions (whether by
registration or otherwise) are available.

     13. TERMINATION OR AMENDMENT OF PLAN OR OPTIONS. The Board, may terminate
or amend the Plan or any Option at any time. In any event, no amendment may
adversely affect any then outstanding Option or any unexercised portion thereof,
without the written consent of the Optionee. Any determination relating to the
amendment or termination of the Plan may not be delegated or assigned to the
Committee

                                       9

                                                                      APPENDIX A

                                NICE SYSTEMS LTD.
                             2003 STOCK OPTION PLAN

              U.S. OPTIONEES - INCENTIVE STOCK OPTION REQUIREMENTS

     Notwithstanding anything to the contrary contained in the Plan, for an
Option to qualify as an "incentive stock option" within the meaning of section
422 of the Code ("ISO"), the following requirements shall apply:

     1. Solely individuals who are employees of the Company or a parent
corporation or subsidiary corporation of the Company (as defined in section
424(e) and 424(f) of the Code) shall be eligible for the grant of an ISO.

     2. The exercise price per share under each ISO shall be not less than 100%
of the fair market value of an Ordinary Share on the date of grant of such ISO;
PROVIDED that the exercise price per share under each ISO granted to an Optionee
who, on the date of grant, owns stock possessing more than 10% of the total
combined voting power of the Company or a parent corporation or subsidiary
corporation of the Company (as defined in section 424(e) and 424(f) of the Code)
shall not be less than 110% of the fair market value of an Ordinary Share on the
date of grant of such ISO.

     3. No ISO shall be exercisable for more than 10 years from its date of
grant; PROVIDED that an ISO granted to an Optionee who, on the date of grant,
owns stock possessing more than 10% of the total combined voting power of the
Company or a parent corporation or subsidiary corporation of the Company (as
defined in section 424(e) and 424(f) of the Code), shall not be exercisable for
more than 5 years from its date of grant.

     4. The aggregate fair market value (determined at the time of grant) of the
Ordinary Shares with respect to which ISOs are exercisable for the first time by
an Optionee during any calendar year (under all stock option plans of the
Company or any subsidiary or parent corporation of the Company (as defined in
section 424(e) and 424(f) of the Code)) shall not exceed $100,000.

                                       10

     5. For purposes of the Optionee of an ISO, the term "disability" shall mean
the inability to engage in any substantial gainful activity by reason of any
medically determinable physical or mental impairment which can be expected to
result in death or which has lasted or can be expected to last for a continuous
period of not less than 12 months, all as described in section 22(e)(3) of the
Code.

     6. For all purposes of this Appendix A, the term "fair market value" as of
any date shall mean the closing sales price of the Company's American Depositary
Receipts (ADRs) on the trading date immediately preceding such date as quoted on
NASDAQ, or, if there have been no quoted closing sales prices with respect to
the ADRs or if the NASDAQ is not open for business on such trading date, as
determined by the Board in good faith.

                                       11

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