Document:

EX-10.6 Employment Letter Agreement

 

Exhibit 10.6

August 4, 2006

Mr. Scott Bromley

441 127th Lane NW

Coon Rapids, MN 55448

     Re:      Employment matters related to Bioheart, Inc. (the “Company”)

Dear Scott:

     This letter agreement (the “Agreement”) shall set forth the agreements between you and the
Company in connection with any and all issues related to your past, present and continued
employment with the Company. Each of you and the Company hereby agree as follows:

     1. As full and complete settlement for unpaid salary or other compensation that may be owed to
you for services rendered prior to the date of this Agreement, the Company shall issue to you
77,143 shares of the Company common stock, par value $.001 per share (the “Shares”). Additionally,
the Company shall reimburse you an amount equal to all federal and state income taxes actually paid
by you as a direct result of the issuance of the Shares. It is the intention of you and the
Company that the value of each Share shall be equal to $3.50 and the aggregate value of the Shares,
plus the reimbursement to you of amounts payable by you for state and federal income taxes directly
as a result of the issuance of the Shares to you shall be equal to approximately $390,000.

     2. Subject to the terms and conditions of this Agreement, you agree to continue your
employment with the Company as Vice President, Public Relations. The Company will pay you an
annual salary equal to $130,000 (the “Salary”), and you shall continue to be eligible to
participate in the benefit plans that the Company as provided to you and your family, if
applicable, prior to the date of this Agreement. It is agreed that you will continue your public
relations activities and fundraising activities as a part of your employment duties, and no
additional compensation will be due to you for securing additional investment capital. In this
regard, it is agreed that you will use your best efforts to raise a minimum of $1 million of
investment capital for the Company during its next round of financing. Each of you and the Company
understand that this Agreement is not a contract of employment for any definite term. Your
employment with the Company shall continue to be “at-will,” and may be terminated at any time, for
any reason, with or without cause or notice, by either you or the Company.

     3. You and the Company each ratify and affirm the validity of the following options granted to
you: (i) an option to purchase 100,000 shares of common stock with an as adjusted exercise price
of $0.79 per share which were granted to you on December 25, 1999 pursuant to

13794 NW 4th Street, Suite 212

Sunrise, Florida 33325 USA

Tel: 954-835-1500

 

 

Scott Bromley

August 4, 2006

Page 2 of 3

an Incentive Option Agreement, a copy of which is attached hereto as Exhibit A; (ii)
an option to purchase 42,000 shares of common stock with an as adjusted exercise price of $3.50 per
share which were granted to you on December 18, 2000 pursuant to an Incentive Option Agreement, a
copy of which is attached hereto as Exhibit B; and (iii) an option to purchase 500 shares
of common stock with an exercise price of $3.50 per share which were granted to you on December 31,
2005 pursuant to an Incentive Option Agreement, a copy of which is attached hereto as Exhibit
C. We each agree that any all options which may have been previously granted to you by the
Company are hereby terminated, and you agree not to seek to revive, exercise or transfer any such
options. In order to increase the total number of options granted to
you by the Company to 600,000,
which is the maximum amount permitted under the Company’s 1999 Officers and Employees Stock Option
Plan (the “1999 Plan”), effective upon the execution of this Agreement, the Company hereby grants
you an “incentive” stock option top purchase 457,500 shares of the Company’s common stock, par
value $.001 per share, under and in accordance with the 1999 Plan, which options shall be fully
vested and exercisable for a period of ten (10) years from the date of grant at a per share
exercise price equal to $3.50, all in accordance with the Option Agreement attached to this
Agreement as Exhibit D.

     4. Effective upon the execution of this Agreement, the Company hereby grants you a warrant to
purchase 305,000 shares of the Company’s common stock, par value $.001 per share, at the per share
exercise price of $3.50, which warrant shall be fully vested and exercisable for a period of ten
(10) years from the date of grant, all in accordance with the Warrant attached to this Agreement as
Exhibit E.

     5. It is expressly understood and agreed that except as set forth in this Agreement, you are
not entitled to, you shall have no right to, and you agree that you shall not request or pursue,
any additional compensation from the Company, whether in the form of cash, stock, options,
warrants, Company benefits or otherwise.

     6. In exchange for the covenants, promises and payments set forth in this Agreement, you agree
to waive, release, remise, acquit, and forever discharge the Company, its officers, directors,
employees, successors, attorneys, administrators, trustees, and assigns, from and against any and
all actions, causes of action, claims, demands, damages, costs, expenses and debts whatsoever
(collectively, the “Claims” and individually, a “Claim”), whether in law and in equity, which you
have, have had, or which you or your agents, servants, employees, heirs, successors, attorneys,
administrators, trustees, and assignees can, shall or may have against the Company on account of or
in any way growing out of or relating to, any matter or thing which has happened, developed or
occurred from the beginning of the world to the date of this Agreement, whether known or unknown,
suspected or unsuspected, including, without limitation, any such Claims which are in any way
connected with, based upon, related to or arising out of any amounts or obligations owed or payable
to you by the Company, your employment by the Company or the services provided by you to the
Company. In exchange for the covenants and promises set forth in this Agreement, the Company
agrees to waive, release, remise, acquit, and forever discharge you and your assigns from and
against any and all Claims, whether in law and in equity, which it has, has had, or which it or its
agents, servants, employees, heirs, successors, attorneys, administrators, trustees, and assignees
can, shall or may have against

 

 

Scott Bromley

August 4, 2006

Page 3 of 3

you on account of or in any way growing out of or relating to, any matter or thing which has
happened, developed or occurred from the beginning of the world to the date of this Agreement,
whether known or unknown, suspected or unsuspected, including, without limitation, any such Claims
which are in any way connected with, based upon, related to or arising out of any amounts or
obligations owed or payable to the Company by you, your employment by the Company or the services
provided by you to the Company.

     7. You agree that in the event your employment by the Company is terminated for any reason,
you will assist the Company, as requested, in the professional transition of work in progress,
duties, files and pertinent information, including, but not limited to the preservation of positive
relationships between the Company and its investors. You also agree not make any oral or written
statement or engage in conduct of any kind that either directly or indirectly disparages,
criticizes, defames or otherwise casts a negative characterization upon the Company or its
shareholders, officers, directors, employees, or their relatives, nor shall you direct, encourage
or assist anyone else to do so. You further agree not to take any action which could harm the
relationship between the Company and its investors or potential investors.

     8. This Agreement and all controversies arising from or related to performance under this
Agreement shall be governed by the internal laws of the State of Florida without regard to its
rules concerning conflicts of laws. The parties exclusively, irrevocably and unconditionally
submit to the exclusive jurisdiction of the courts of the State of Florida located in Broward
County or in the United States District Court located in Broward County, Florida for the purposes
of any suit, action or other proceeding arising out of this Agreement or the subject matter hereof
brought by any party hereto.

     If this letter is consistent with your understanding of our agreement, please execute this
letter in the space provided below. If you have any questions, or if you need additional
information, please do not hesitate to contact me.

	 	 	 	 	 
	 	Very truly yours,

Bioheart, Inc.

 	 
	 	By:  	/s/
 	 
	 	 	Howard J. Leonhardt, 	 
	 	 	Chief Executive Officer 	 
	 

	 	 	 	 	 
	 	Acknowledged and agreed to

this 24th day of August 2006.

 	 
	 	/s/
Scott Bromley
 	 
	 	Scott Bromley 	 
	 	 	 
	 

 

 

EXHIBIT A

BIOHEART, INC.

INCENTIVE STOCK OPTION AGREEMENT

FOR

Scott Bromley

Agreement

     1. Grant of Option. BIOHEART, INC. (the “Company”) hereby grants, as of December 25,
1999 (the “Date of Grant”), to Scott Bromley (the “Optionee”) an option (the “Option”) to purchase
up to 100,000 shares of the Company’s Common Stock, $.01 par value (the “Stock”), at an exercise
price per share equal to $1.80 (the “Exercise Price”). The Option shall be subject to the terms
and conditions set forth herein. The Option was issued pursuant to the Company’s 1999 Officers and
Employees Stock Option Plan (the “Plan”), which is incorporated herein for all purposes. The
Option shall be treated by the Company as an incentive stock option within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the “Code”) and not a nonqualified stock
option, if and to the extent that the limitations under Section 4(b) of the Plan and Section 422(d)
of the Code, are not exceeded. The Optionee hereby acknowledges receipt of a copy of the Plan and
agrees to be bound by all of the terms and conditions hereof and thereof.

     2. Definitions. Unless otherwise provided herein, terms used herein that are defined
in the Plan and not defined herein shall have the meanings attributed thereto in the Plan.

     3. Exercise Schedule. Except as otherwise provided in Section 6 or 12 of this
Agreement, or in the Plan, the Option is exercisable in installments as provided below, which shall
be cumulative. To the extent that the Option has become exercisable with respect to a percentage of
Shares as provided below, the Option may thereafter be exercised by the Optionee, in whole or in
part, at any time or from time to time prior to the expiration of the Option as provided herein.
The following table indicates each date (the “Vesting Date”) upon which the Optionee shall be
entitled to exercise the Option with respect to the percentage of Shares granted as indicated
beside the date, provided that the Optionee has been continuously employed by the Company or a
Subsidiary through and on the applicable Vesting Date:

	 	 	 
	Percentage of Shares	 	Vesting Date
	 
	 	 
	25%
	 	first anniversary of Date of Grant
	 
	 	 
	25%
	 	second anniversary of Date of Grant
	 
	 	 
	25%
	 	third anniversary of Date of Grant
	 
	 	 
	25%
	 	fourth anniversary of Date of Grant

     Except as otherwise specifically provided herein, there shall be no proportionate or partial
vesting in the periods prior to each Vesting Date, and all vesting shall occur only on the
appropriate Vesting Date. Upon the Optionee’s termination of employment with the Company

 

 

and its Subsidiaries, any unvested portion of the Option shall terminate and be null and void.

     4. Method of Exercise. This Option shall be exercisable in whole or in part in
accordance with the exercise schedule set forth in Section 3 hereof by written notice which shall
state the election to exercise the Option, the number of Shares in respect of which the Option is
being exercised, and such other representations and agreements as to the holder’s investment intent
with respect to such Shares as may be required by the Company pursuant to the provisions of the
Plan. Such written notice shall be signed by the Optionee and shall be delivered in person or by
certified mail to the Chief Financial Officer of the Company. The written notice shall be
accompanied by payment of the Exercise Price. This Option shall be deemed to be exercised after
(a) receipt by the Company of such written notice accompanied by the Exercise Price, and (b)
arrangements that are satisfactory to the Board or the Committee in its sole discretion have been
made for Optionee’s payment to the Company of the amount that is necessary to be withheld in
accordance with applicable Federal or state withholding requirements. No Shares will be issued
pursuant to the Option unless and until such issuance and such exercise shall comply with all
relevant provisions of applicable law, including the requirements of any stock exchange upon which
the Stock then may be traded.

     5. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee: (a) cash; (b) check; (c)
with Shares that have been held by the Optionee for at least 6 months (or such other Shares as the
Company determines will not cause the Company to recognize for financial accounting purposes a
charge for compensation expense); or (d) such other consideration or in such other manner as may be
determined by the Board or the Committee in its absolute discretion.

     6. Termination of Option.

     (a) Any unexercised portion of the Option shall automatically and without notice terminate and
become null and void at the time of the earliest to occur of:

          (i) three (3) months after the date on which the Optionee’s employment with the Company and
its Subsidiaries is terminated for any reason other than by reason of (A) Cause, which, solely for
purposes of this Agreement, shall mean the termination of the Optionee’s employment by reason of
the Optionee’s willful misconduct or gross negligence, (B) a mental or physical disability (within
the meaning of Section 22(e) of the Internal Revenue Code of 1986, as amended) of the Optionee as
determined by a medical doctor satisfactory to the Committee, or (C) death;

          (ii) immediately upon the termination of the Optionee’s employment with the Company and its
Subsidiaries for Cause;

          (iii) twelve (12) months after the date on which the Optionee’s employment with the Company
and its Subsidiaries is terminated by reason of a mental or physical disability (within the meaning
of Section 22(e) of the Internal Revenue Code of 1986, as amended) as determined by a medical
doctor satisfactory to the Committee;

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          (iv) twelve (12) months after the date of termination of the Optionee’s employment with the
Company and its Subsidiaries by reason of the death of the Optionee (or if later, three months
after the date on which the Optionee shall die if such death shall occur during the one year period
specified in paragraph (iii) of this Section 6);

          (v) immediately in the event that the Optionee shall file any lawsuit or arbitration claim
against the Company or any Subsidiary, or any of their respective officers, directors or
shareholders of the Company;

          (vi) the tenth (10th) anniversary of the Date of Grant; or

          (vii) termination under Section 12 hereof.

     (b) To the extent not previously exercised, (i) the Option shall terminate immediately in the
event of (1) the liquidation or dissolution of the Company, or (2) any reorganization, merger,
consolidation or other form of corporate transaction in which the Company does not survive, unless
the successor corporation, or a parent or subsidiary of such successor corporation, assumes the
Option or substitutes an equivalent option or right pursuant to Section 10(c) of the Plan, and (ii)
the Committee or the Board in its sole discretion may by written notice (“cancellation notice”)
cancel, effective upon the consummation of any corporate transaction described in Subsection
8(b)(i) of the Plan in which the Company does survive, any Option that remains unexercised on such
date. The Committee or the Board shall give written notice of any proposed transaction referred to
in this Section 6(b) a reasonable period of time prior to the closing date for such transaction
(which notice may be given either before or after approval of such transaction), in order that the
Optionee may have a reasonable period of time prior to the closing date of such transaction within
which to exercise the Option if and to the extent that it then is exercisable (including any
portion of the Option that may become exercisable upon the closing date of such transaction). The
Optionee may condition his exercise of the Option upon the consummation of a transaction referred
to in this Section 6(b).

     7. Transferability. The Option granted hereby is not transferable otherwise than by
will or under the applicable laws of descent and distribution, and during the lifetime of the
Optionee the Option shall be exercisable only by the Optionee or the Optionee’s guardian or legal
representative. In addition, the Option shall not be assigned, negotiated, pledged or hypothecated
in any way (whether by operation of law or otherwise), and the Option shall not be subject to
execution, attachment or similar process. Upon any attempt to transfer, assign, negotiate, pledge
or hypothecate the Option, or in the event of any levy upon the Option by reason of execution,
attachment or similar process contrary to the provisions hereof, the Option shall immediately
become null and void.

     8. No Rights of Stockholders. Neither the Optionee nor any personal representative
(or beneficiary) shall be, or shall have any of the rights and privileges of, a stockholder of the
Company with respect to any shares of Stock purchasable or issuable upon the exercise of the
Option, in whole or in part, prior to the date of exercise of the Option.

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     9. Stockholders Agreements; Restrictions.

     (a) Stockholders Agreement. Unless the requirements under this sentence are waived in
writing by the Company, the Optionee shall not be permitted to exercise the Option or to be issued
any shares of Stock thereunder unless and until the Optionee executes and delivers to the Company
the form of stockholders agreement then in effect among the Company and its stockholders (which
agreement may be the stockholders agreement utilized in connection with the Company’s initial
private offering to investors) (the “Stockholders Agreement”). In addition to any rights or
obligations of Optionee under such Stockholders Agreement, the Optionee is and shall be subject to
the following provisions of this Section 9 and the other provisions of this Option Agreement.

     (b) Restrictions While Stock is Not Registered; Restricted Shares. The shares of
Stock subject to the Option specified in Section 1 and (i) all shares of the Company’s capital
stock received as a dividend or other distribution upon such shares, and (ii) all shares of capital
stock or other securities of the Company into which such shares may be changed or for which such
shares shall be exchanged, whether through reorganization, recapitalization, stock split-ups or the
like, shall be subject to the provisions of this Section 9 at all times, and only at those times,
that shares of the Company’s Common Stock are not Publicly-Held (such times during which the Stock
is not so Publicly-Held hereinafter being referred to as the “Restricted Period”) and are during
the Restricted Period hereinafter referred to as “Restricted Shares.” For purposes of this
Agreement, “Publicly-Held” means that the Common Stock of the Company, or the stock of any
successor company into which the Common Stock is substituted or exchanged, is registered pursuant
to Section 12(b) or 12(g) of the Securities Exchange Act.

     (c) No Sale or Pledge of Restricted Shares. Except as otherwise provided herein, the
Optionee agrees and covenants that during the Restricted Period he or she will not sell, pledge,
encumber or otherwise transfer or dispose of, and will not permit to be sold, encumbered, attached
or otherwise disposed of or transferred in any manner, either voluntarily or by operation of law
(all hereinafter collectively referred to as “transfers”), all or any portion of the Restricted
Shares or any interest therein except in accordance with and subject to the terms of this Section
9.

     (d) Involuntary Transfer Repurchase Option. Whenever, during the Restricted Period,
the Optionee has any notice or knowledge of any attempted, pending, or consummated involuntary
transfer or lien or charge upon any of the Restricted Shares, whether by operation of law or
otherwise, the Optionee shall give immediate written notice thereof to the Company. Whenever the
Company has any other notice or knowledge of any such attempted, impending, or consummated
involuntary transfer, lien, or charge, it shall give written notice thereof to the Optionee. In
either case, the Optionee agrees to disclose forthwith to the Company all pertinent information in
his possession relating thereto. If during the Restricted Period any of the Restricted Shares are
subjected to any such involuntary transfer, lien, or charge, the Company and its designated
purchaser shall at all times have the immediate and continuing option to purchase such of the
Restricted Shares upon notice by the Company to the Optionee or other record holder at a price
determined according to Section 9(f) below, and any of the Restricted Shares so purchased by the
Company or its designated purchaser shall in every case be free and

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clear of such transfer, lien, or charge.

     (e) Repurchase Option on Termination of Employment. Anything set forth in this
Agreement to the contrary notwithstanding, the Company shall have the right (but not the
obligation) to purchase or designate a purchaser of all, but not less than all, of the Restricted
Shares (including, without limitation, any Restricted Shares transferred pursuant to Section 2.3.1
of the Stockholders Agreement) during the Restricted Period and after termination of the Optionee’s
employment relationship with the Company for any reason, for the purchase price specified in
Section 9(f) hereof. The Company may exercise its right to purchase or designate a purchaser of
the Restricted Shares at any time (without any time limitation) after the Optionee’s termination of
employment or service and during the Restricted Period. If the Company chooses to exercise its
right to purchase the Restricted Shares hereunder, the Company shall give its notice of its
exercise of this right to the Optionee or his or her legal representative specifying in such notice
a date not later than ten (10) days following the date of giving such notice on which the Company
or its designated purchaser shall deliver, or be prepared to deliver the check or promissory note
for the purchase price and the Optionee or his or her legal representative shall deliver all stock
certificates evidencing such Restricted Shares duly endorsed in blank for transfer or with separate
stock powers endorsed in blank for transfer.

     (f) Repurchase Price. For purposes of Section 9(d) and (e) hereof, the per share
purchase price of Restricted Shares shall be an amount equal to the Fair Market Value of such
share, determined by the Board or the Committee as of any date determined by the Board or the
Committee that is not more than one year prior to the date of the event giving rise to the
Company’s right to purchase such Restricted Shares under this Section 9. Any determination of Fair
Market Value made by the Board or the Committee shall be binding and conclusive on all parties
unless shown to have been made in an arbitrary and capricious manner. The purchase price shall, at
the option of the Company, be payable in cash or in the form of the Company’s promissory note
payable in up to three equal annual installments commencing 12 months after the acquisition by the
Company (“Acquisition Date”) of the Restricted Shares, together with interest on the unpaid balance
thereof at the rate equal to the prime rate of interest of Citibank, N.A. on the Acquisition Date.

     (g) Voting Rights. As a condition to Optionee’s exercise of any Option pursuant to
this Agreement, the Company may in its discretion require that Optionee enter into a voting
agreement that grants to specified persons designated therein the voting rights for all shares of
Stock acquired pursuant to the exercise of such Options, until the earlier of (i) 10 years from the
date of exercise of the Option, or (ii) the end of the Restricted Period, such voting agreement to
be in such form as the Company reasonably may request.

     (h) Legends. The certificate or certificates representing any Shares acquired
pursuant to the exercise of an Option prior to the last day of the Restricted Period shall bear the
following legends (as well as any legends required by applicable state and federal corporate and
securities laws or the Stockholders Agreement):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE “ACT”)

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AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR
HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR, IN THE OPINION OF
COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE
SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS IN
COMPLIANCE THEREWITH.

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER, RIGHT OF FIRST REFUSAL AND REDEMPTION OR
REPURCHASE OPTIONS HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE
STOCK OPTION AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE
SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE
ISSUER. SUCH TRANSFER RESTRICTIONS, RIGHT OF FIRST REFUSAL AND REDEMPTION
OR REPURCHASE RIGHTS ARE BINDING ON TRANSFEREES OF THESE SHARES.

     10. Market Stand-Off Agreement. In the event of an initial public offering
of the Company’s securities and upon request of the Company or the underwriters managing any
underwritten offering of the Company’s securities, the Optionee agrees not to sell, make any short
sale of, loan, grant any option for the purchase of, or otherwise dispose of any Shares (other than
those included in the registration) acquired pursuant to the exercise of the Option, without the
prior written consent of the Company or such underwriters, as the case may be, for such period of
time (not to exceed 180 days) from the effective date of such registration as may be requested by
the Company or such managing underwriters.

     11. Optionee’s Representations. By executing this Agreement, Optionee hereby
represents and warrants to the Company as to all provisions set forth in the Investment
Representation Statement attached hereto as Exhibit A. In addition, in the event the Company’s
issuance of the Shares purchasable pursuant to the exercise of this Option has not been registered
under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall,
if required by the Company, concurrently with the exercise of all or any portion of this Option,
execute and deliver to the Company such Investment Representation Statement or such other form as
the Company may request.

     12. Options Terminate if Optionee Violates Agreements. The Participant hereby
acknowledges and agrees, as a condition to receiving a grant of the Options, and the receiving of
Shares upon exercise of such Options, to be bound by the restrictive covenant provisions of that
certain Employment Agreement, dated ___, entered into by and between the Company and the
Participant, as well as any and all restrictive covenant agreements including the Noncompetition
Agreement and the Inventions and Proprietary Rights Assignment and Confidentiality Agreement. In
the event the Participant breaches any of the restrictive covenant provisions and/or agreements,
the Board may, within its sole and absolute discretion and upon written notice to the Optionee,
terminate this Agreement and, consequently (a) the Options

6

 

hereunder shall become immediately void and shall no longer have any force any effect, and (b)
any and all Shares Optionee received pursuant to this Agreement must be returned to the Company
immediately upon demand by the Company upon the Company’s return of the exercise price paid by the
Optionee. The determination as to whether the Executive has breached any of the restrictive
covenant provisions and/or agreements shall be made by the Board, in good faith, and shall be
binding and conclusive on all parties.

     13. Acceleration of Exercisability of Option. Except as otherwise determined by the
Board or the Committee, in its sole and absolute discretion, this Option shall become immediately
exercisable in the event of a Change in Control, or in the event the Committee or the Board
exercises its discretion to cancel the Option pursuant to Sections 6(b) or (c) hereof.

     14. No Right to Continued Employment. Neither the Option nor this Agreement shall
confer upon the Optionee any right to continued employment or service with the Company.

     15. Law Governing. This Agreement shall be governed in accordance with and governed
by the internal laws of the State of Florida.

     16. Incentive Stock Option Treatment. The terms of this Option shall be interpreted
in a manner consistent with the intent of the Company and the Optionee that the Option qualify as
an Incentive Stock Option under Section 422 of the Code. If any provision of the Plan or the
Agreement shall be impermissible in order for the Option to qualify as an Incentive Stock Option,
then the Option shall be construed and enforced as if such provision had never been included in the
Plan or the Option.

     17. Interpretation. The Optionee accepts the Option subject to all the terms and
provisions of the Plan and this Agreement. The undersigned Optionee hereby accepts as binding,
conclusive and final all decisions or interpretations of the Committee upon any questions arising
under the Plan and this Agreement.

     18. Notices. Any notice under this Agreement shall be in writing and shall be deemed
to have been duly given when delivered personally or when deposited in the United States mail,
registered, postage prepaid, and addressed, in the case of the Company, to the Company’s Secretary
at 3425 Stallion Lane, Weston, Florida 33331, or if the Company should move its principal office,
to such principal office, and, in the case of the Optionee, to the Optionee’s last permanent
address as shown on the Company’s records, subject to the right of either party to designate some
other address at any time hereafter in a notice satisfying the requirements of this Section.

     19. Tax Consequences. Set forth below is a brief summary as of the date of this
Option of certain of the federal tax consequences of exercise of this Option and disposition of the
Shares under the law in effect as of the date of grant. THIS SUMMARY IS NECESSARILY INCOMPLETE,
AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. OPTIONEE SHOULD CONSULT A TAX ADVISER
BEFORE EXERCISING THIS OPTION OR DISPOSING OF THE SHARES.

     (a) Exercise of Option. There will be no regular federal income tax liability
upon the exercise of the Option, although the excess, if any, of the fair market value of
the Shares on the date of exercise over the Exercise Price will be treated as an adjustment
to the alternative minimum tax for federal tax purposes and may subject the Optionee to the
alternative minimum tax in the year of exercise.

     (b) Disposition of Shares. If Shares transferred pursuant to the Option are
held for at least one year after exercise and are disposed of at least two years after the
Date of Grant, any gain realized on disposition of the Shares will also be treated as
long-term capital gain for federal income tax purposes. If Shares purchased under an
Option are disposed of within such one-year period or within two years after the Date of
Grant, any gain realized on such disposition will be treated as compensation income (taxable
at ordinary income rates) to the extent of the difference between the Exercise Price and the
lesser of (1) the fair market value of the Shares on the date of exercise, or (2) the sale
price of the Shares.

     (c) Notice of Disqualifying Disposition of Option Shares. If the Optionee
sells or otherwise disposes of any of the Shares acquired pursuant to the Option on or
before the later of (1) the date two years after the Date of Grant, (2) the date one year
after the date of exercise, the Optionee shall immediately notify the Company in writing of
such disposition. The Optionee agrees that the Optionee may be subject to the income tax
withholding by the Company on the compensation income recognized by the Optionee from the
early disposition by payment in cash or out of the current earnings paid to the Optionee.

     The foregoing discussion assumes that, and only is applicable if, the fair market value of the
Shares as of the date on which the Option is granted is not less than the Exercise Price. The
Company believes that it has made a good faith effort to determine the fair market value of the
Shares and does not believe that the Exercise Price is less than the fair market value of the
Shares on the Date of Grant. No assurances can be given, however, that the Internal Revenue
Service would not take a contrary position, or that the Internal Revenue Service would not treat
the Option as an Incentive Stock Option for some other reason. If the Exercise Price is determined
to be less than the fair market value of a Share on the Date of Grant, then the Option may be
taxable as a non-qualified option. The holder of a non-qualified option will be treated as having
received compensation income (taxable at ordinary income tax rates) at the time the option is
exercised equal to the excess, if any, of the fair market value of the Shares on the date of
exercise over the Exercise Price. If Shares transferred pursuant to the non-qualified option are
held for at least one year, any gain realized on disposition of the Shares will be treated as
long-term capital gain for federal income tax purposes.

7

 

     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the 25th day of
December 1999.

	 	 	 	 	 
	 	COMPANY:

BIOHEART, INC.

 	 
	 	By:  	/s/
 	 
	 	 	John L. Babitt 	 
	 	 	Chief Financial Officer 	 
	 

     Optionee acknowledges receipt of a copy of the Plan and represents that he or she is familiar
with the terms and provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had
an opportunity to obtain the advice of counsel prior to executing this Option, and fully
understands all provisions of the Option.

	 	 	 	 	 
	Dated:                                                           	OPTIONEE:

 	 
	 	By:  	 	 
	 	 	Scott Bromley 	 
	 	 	 	 

8

 

	 	 	 	 	 

EXHIBIT A

INVESTMENT REPRESENTATION STATEMENT

	 	 	 	 	 
	PURCHASER	 	:	 	 

	 	 	 	 	 
	COMPANY	 	:	 	BIOHEART, INC.

	 	 	 	 	 
	SECURITY	 	:	 	COMMON STOCK

	 	 	 	 	 
	AMOUNT	 	:	 	 

	 	 	 	 	 
	DATE	 	:	 	 

In connection with the grant and exercise of options to purchase of the above-listed Securities, I,
the Purchaser, represent to the Company the following:

     (a) I am aware of the Company’s business affairs and financial condition, and have acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Securities. I am purchasing these Securities for my own account for investment purposes only
and not with a view to, or for the resale in connection with, any “distribution” thereof for
purposes of the Securities Act of 1933, as amended (the “Securities Act”).

     (b) I understand that the Company’s issuance of the Securities has not been registered under
the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon,
among other things, the bona fide nature of my investment intent as expressed herein. In this
connection, I understand that, in the view of the Securities and Exchange Commission (the “SEC”),
the statutory basis for such exemption may be unavailable if my representation was predicated
solely upon a present intention to hold these Securities for the minimum capital gains period
specified under tax statutes, for a deferred sale, for or until an increase or decrease in the
market price of the Securities, or for a period of one year or any other fixed period in the
future.

     (c) I further understand that the Securities must be held by me indefinitely unless the
transfer is subsequently registered under the Securities Act or unless an exemption from
registration is otherwise available, and that I cannot transfer or sell any Securities unless
permitted under my Stock Option Agreement and the Stockholders Agreement referenced in Section 9(a)
of this Stock Option Agreement. Moreover, I understand that the Company is under no obligation to
register any transfer of the Securities. In addition, I understand that the certificate evidencing
the Securities will be imprinted with a legend which prohibits the transfer of the Securities
unless registered or such registration is not required in the opinion of counsel for the Company.

     (d) I am familiar and agree to comply with the provisions of Rule 701 and Rule 144, each
promulgated under the Securities Act, which, in substance, permit limited public resale of
“restricted securities” acquired, directly or indirectly, from the issuer thereof, in a
non-public offering subject to the satisfaction of certain conditions, subject to the requirements
of my Stock Option Agreement and the Stockholders Agreement.

	 	 	 	 	 
	 	Signature of Purchaser:

 	 
	 	 	 
	 	 	 
	 	 	 
	 

Date:                                         

9

 

EXHIBIT B

BIOHEART, INC.

INCENTIVE STOCK OPTION AGREEMENT

FOR

Scott Bromley

Agreement

     1. Grant of Option. BIOHEART, INC. (the “Company”) hereby grants, as of December 18,
2000 (the “Date of Grant”), to Scott Bromley (the “Optionee”) an option (the “Option”) to purchase
up to 42,000 shares of the Company’s Common Stock, $.01 par value (the “Stock”), at an exercise
price per share equal to $8.00 (the “Exercise Price”). The Option shall be subject to the terms
and conditions set forth herein. The Option was issued pursuant to the Company’s 1999 Officers and
Employees Stock Option Plan (the “Plan”), which is incorporated herein for all purposes. The
Option shall be treated by the Company as an incentive stock option within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the “Code”) and not a nonqualified stock
option, if and to the extent that the limitations under Section 4(b) of the Plan and Section 422(d)
of the Code, are not exceeded. The Optionee hereby acknowledges receipt of a copy of the Plan and
agrees to be bound by all of the terms and conditions hereof and thereof.

     2. Definitions. Unless otherwise provided herein, terms used herein that are defined
in the Plan and not defined herein shall have the meanings attributed thereto in the Plan.

     3. Exercise Schedule. Except as otherwise provided in Section 6 or 12 of this
Agreement, or in the Plan, the Option is exercisable in installments as provided below, which shall
be cumulative. To the extent that the Option has become exercisable with respect to a percentage of
Shares as provided below, the Option may thereafter be exercised by the Optionee, in whole or in
part, at any time or from time to time prior to the expiration of the Option as provided herein.
The following table indicates each date (the “Vesting Date”) upon which the Optionee shall be
entitled to exercise the Option with respect to the percentage of Shares granted as indicated
beside the date, provided that the Optionee has been continuously employed by the Company or a
Subsidiary through and on the applicable Vesting Date:

	 	 	 
	Percentage of Shares	 	Vesting Date
	 
	 	 
	17%
	 	January 31, 2001
	16%
	 	February 28, 2001
	17%
	 	March 31, 2001
	17%
	 	April 30, 2001
	17%
	 	May 31, 2001
	16%
	 	June 30, 2001

 

 

     Except as otherwise specifically provided herein, there shall be no proportionate or partial
vesting in the periods prior to each Vesting Date, and all vesting shall occur only on the
appropriate Vesting Date. Upon the Optionee’s termination of employment with the Company and its
Subsidiaries, any unvested portion of the Option shall terminate and be null and void.

     4. Method of Exercise. This Option shall be exercisable in whole or in part in
accordance with the exercise schedule set forth in Section 3 hereof by written notice which shall
state the election to exercise the Option, the number of Shares in respect of which the Option is
being exercised, and such other representations and agreements as to the holder’s investment intent
with respect to such Shares as may be required by the Company pursuant to the provisions of the
Plan. Such written notice shall be signed by the Optionee and shall be delivered in person or by
certified mail to the Chief Financial Officer of the Company. The written notice shall be
accompanied by payment of the Exercise Price. This Option shall be deemed to be exercised after
(a) receipt by the Company of such written notice accompanied by the Exercise Price, and (b)
arrangements that are satisfactory to the Board or the Committee in its sole discretion have been
made for Optionee’s payment to the Company of the amount that is necessary to be withheld in
accordance with applicable Federal or state withholding requirements. No Shares will be issued
pursuant to the Option unless and until such issuance and such exercise shall comply with all
relevant provisions of applicable law, including the requirements of any stock exchange upon which
the Stock then may be traded.

     5. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee: (a) cash; (b) check; (c)
with Shares that have been held by the Optionee for at least 6 months (or such other Shares as the
Company determines will not cause the Company to recognize for financial accounting purposes a
charge for compensation expense); or (d) such other consideration or in such other manner as may be
determined by the Board or the Committee in its absolute discretion.

     6. Termination of Option.

     (a) Any unexercised portion of the Option shall automatically and without notice terminate and
become null and void at the time of the earliest to occur of:

          (i) three (3) months after the date on which the Optionee’s employment with the Company and
its Subsidiaries is terminated for any reason other than by reason of (A) Cause, which, solely for
purposes of this Agreement, shall mean the termination of the Optionee’s employment by reason of
the Optionee’s willful misconduct or gross negligence, (B) a mental or physical disability (within
the meaning of Section 22(e) of the Internal Revenue Code of 1986, as amended) of the Optionee as
determined by a medical doctor satisfactory to the Committee, or (C) death;

          (ii) immediately upon the termination of the Optionee’s employment with the Company and its
Subsidiaries for Cause;

          (iii) twelve (12) months after the date on which the Optionee’s employment with the Company
and its Subsidiaries is terminated by reason of a mental or physical disability

2

 

(within the meaning of Section 22(e) of the Internal Revenue Code of 1986, as amended) as
determined by a medical doctor satisfactory to the Committee;

          (iv) twelve (12) months after the date of termination of the Optionee’s employment with the
Company and its Subsidiaries by reason of the death of the Optionee (or if later, three months
after the date on which the Optionee shall die if such death shall occur during the one year period
specified in paragraph (iii) of this Section 6);

          (v) immediately in the event that the Optionee shall file any lawsuit or arbitration claim
against the Company or any Subsidiary, or any of their respective officers, directors or
shareholders of the Company;

          (vi) the tenth (10th) anniversary of the Date of Grant; or

          (vii) termination under Section 12 hereof.

     (b) To the extent not previously exercised, (i) the Option shall terminate immediately in the
event of (1) the liquidation or dissolution of the Company, or (2) any reorganization, merger,
consolidation or other form of corporate transaction in which the Company does not survive, unless
the successor corporation, or a parent or subsidiary of such successor corporation, assumes the
Option or substitutes an equivalent option or right pursuant to Section 10(c) of the Plan, and (ii)
the Committee or the Board in its sole discretion may by written notice (“cancellation notice”)
cancel, effective upon the consummation of any corporate transaction described in Subsection
8(b)(i) of the Plan in which the Company does survive, any Option that remains unexercised on such
date. The Committee or the Board shall give written notice of any proposed transaction referred to
in this Section 6(b) a reasonable period of time prior to the closing date for such transaction
(which notice may be given either before or after approval of such transaction), in order that the
Optionee may have a reasonable period of time prior to the closing date of such transaction within
which to exercise the Option if and to the extent that it then is exercisable (including any
portion of the Option that may become exercisable upon the closing date of such transaction). The
Optionee may condition his exercise of the Option upon the consummation of a transaction referred
to in this Section 6(b).

     7. Transferability. The Option granted hereby is not transferable otherwise than by
will or under the applicable laws of descent and distribution, and during the lifetime of the
Optionee the Option shall be exercisable only by the Optionee or the Optionee’s guardian or legal
representative. In addition, the Option shall not be assigned, negotiated, pledged or hypothecated
in any way (whether by operation of law or otherwise), and the Option shall not be subject to
execution, attachment or similar process. Upon any attempt to transfer, assign, negotiate, pledge
or hypothecate the Option, or in the event of any levy upon the Option by reason of execution,
attachment or similar process contrary to the provisions hereof, the Option shall immediately
become null and void.

     8. No Rights of Stockholders. Neither the Optionee nor any personal representative
(or beneficiary) shall be, or shall have any of the rights and privileges of, a stockholder of the
Company with respect to any shares of Stock purchasable or issuable upon the exercise of the
Option, in whole or in part, prior to the date of exercise of the Option.

3

 

     9. Stockholders Agreements; Restrictions.

     (a) Stockholders Agreement. Unless the requirements under this sentence are waived in
writing by the Company, the Optionee shall not be permitted to exercise the Option or to be issued
any shares of Stock thereunder unless and until the Optionee executes and delivers to the Company
the form of stockholders agreement then in effect among the Company and its stockholders (which
agreement may be the stockholders agreement utilized in connection with the Company’s initial
private offering to investors) (the “Stockholders Agreement”). In addition to any rights or
obligations of Optionee under such Stockholders Agreement, the Optionee is and shall be subject to
the following provisions of this Section 9 and the other provisions of this Option Agreement.

     (b) Restrictions While Stock is Not Registered; Restricted Shares. The shares of
Stock subject to the Option specified in Section 1 and (i) all shares of the Company’s capital
stock received as a dividend or other distribution upon such shares, and (ii) all shares of capital
stock or other securities of the Company into which such shares may be changed or for which such
shares shall be exchanged, whether through reorganization, recapitalization, stock split-ups or the
like, shall be subject to the provisions of this Section 9 at all times, and only at those times,
that shares of the Company’s Common Stock are not Publicly-Held (such times during which the Stock
is not so Publicly-Held hereinafter being referred to as the “Restricted Period”) and are during
the Restricted Period hereinafter referred to as “Restricted Shares.” For purposes of this
Agreement, “Publicly-Held” means that the Common Stock of the Company, or the stock of any
successor company into which the Common Stock is substituted or exchanged, is registered pursuant
to Section 12(b) or 12(g) of the Securities Exchange Act.

     (c) No Sale or Pledge of Restricted Shares. Except as otherwise provided herein, the
Optionee agrees and covenants that during the Restricted Period he or she will not sell, pledge,
encumber or otherwise transfer or dispose of, and will not permit to be sold, encumbered, attached
or otherwise disposed of or transferred in any manner, either voluntarily or by operation of law
(all hereinafter collectively referred to as “transfers”), all or any portion of the Restricted
Shares or any interest therein except in accordance with and subject to the terms of this Section
9.

     (d) Involuntary Transfer Repurchase Option. Whenever, during the Restricted Period,
the Optionee has any notice or knowledge of any attempted, pending, or consummated involuntary
transfer or lien or charge upon any of the Restricted Shares, whether by operation of law or
otherwise, the Optionee shall give immediate written notice thereof to the Company. Whenever the
Company has any other notice or knowledge of any such attempted, impending, or consummated
involuntary transfer, lien, or charge, it shall give written notice thereof to the Optionee. In
either case, the Optionee agrees to disclose forthwith to the Company all pertinent information in
his possession relating thereto. If during the Restricted Period any of the Restricted Shares are
subjected to any such involuntary transfer, lien, or charge, the Company and its designated
purchaser shall at all times have the immediate and continuing option to

4

 

purchase such of the Restricted Shares upon notice by the Company to the Optionee or other record
holder at a price determined according to Section 9(f) below, and any of the Restricted Shares so
purchased by the Company or its designated purchaser shall in every case be free and clear of such
transfer, lien, or charge.

     (e) Repurchase Option on Termination of Employment. Anything set forth in this
Agreement to the contrary notwithstanding, the Company shall have the right (but not the
obligation) to purchase or designate a purchaser of all, but not less than all, of the Restricted
Shares (including, without limitation, any Restricted Shares transferred pursuant to Section 2.3.1
of the Stockholders Agreement) during the Restricted Period and after termination of the Optionee’s
employment relationship with the Company for any reason, for the purchase price specified in
Section 9(f) hereof. The Company may exercise its right to purchase or designate a purchaser of
the Restricted Shares at any time (without any time limitation) after the Optionee’s termination of
employment or service and during the Restricted Period. If the Company chooses to exercise its
right to purchase the Restricted Shares hereunder, the Company shall give its notice of its
exercise of this right to the Optionee or his or her legal representative specifying in such notice
a date not later than ten (10) days following the date of giving such notice on which the Company
or its designated purchaser shall deliver, or be prepared to deliver the check or promissory note
for the purchase price and the Optionee or his or her legal representative shall deliver all stock
certificates evidencing such Restricted Shares duly endorsed in blank for transfer or with separate
stock powers endorsed in blank for transfer.

     (f) Repurchase Price. For purposes of Section 9(d) and (e) hereof, the per share
purchase price of Restricted Shares shall be an amount equal to the Fair Market Value of such
share, determined by the Board or the Committee as of any date determined by the Board or the
Committee that is not more than one year prior to the date of the event giving rise to the
Company’s right to purchase such Restricted Shares under this Section 9. Any determination of Fair
Market Value made by the Board or the Committee shall be binding and conclusive on all parties
unless shown to have been made in an arbitrary and capricious manner. The purchase price shall, at
the option of the Company, be payable in cash or in the form of the Company’s promissory note
payable in up to three equal annual installments commencing 12 months after the acquisition by the
Company (“Acquisition Date”) of the Restricted Shares, together with interest on the unpaid balance
thereof at the rate equal to the prime rate of interest of Citibank, N.A. on the Acquisition Date.

     (g) Voting Rights. As a condition to Optionee’s exercise of any Option pursuant to
this Agreement, the Company may in its discretion require that Optionee enter into a voting
agreement that grants to specified persons designated therein the voting rights for all shares of
Stock acquired pursuant to the exercise of such Options, until the earlier of (i) 10 years from the
date of exercise of the Option, or (ii) the end of the Restricted Period, such voting agreement to
be in such form as the Company reasonably may request.

     (h) Legends. The certificate or certificates representing any Shares acquired
pursuant to the exercise of an Option prior to the last day of the Restricted Period shall bear the
following legends (as well as any legends required by applicable state and federal corporate and
securities laws or the Stockholders Agreement):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE
TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE

5

 

ACT OR, IN THE OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE
ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR
HYPOTHECATION IS IN COMPLIANCE THEREWITH.

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER, RIGHT OF FIRST REFUSAL AND REDEMPTION OR
REPURCHASE OPTIONS HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE
STOCK OPTION AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE
SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE
ISSUER. SUCH TRANSFER RESTRICTIONS, RIGHT OF FIRST REFUSAL AND REDEMPTION
OR REPURCHASE RIGHTS ARE BINDING ON TRANSFEREES OF THESE SHARES.

     10. Market Stand-Off Agreement. In the event of an initial public offering
of the Company’s securities and upon request of the Company or the underwriters managing any
underwritten offering of the Company’s securities, the Optionee agrees not to sell, make any short
sale of, loan, grant any option for the purchase of, or otherwise dispose of any Shares (other than
those included in the registration) acquired pursuant to the exercise of the Option, without the
prior written consent of the Company or such underwriters, as the case may be, for such period of
time (not to exceed 180 days) from the effective date of such registration as may be requested by
the Company or such managing underwriters.

     11. Optionee’s Representations. By executing this Agreement, Optionee hereby
represents and warrants to the Company as to all provisions set forth in the Investment
Representation Statement attached hereto as Exhibit A. In addition, in the event the Company’s
issuance of the Shares purchasable pursuant to the exercise of this Option has not been registered
under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall,
if required by the Company, concurrently with the exercise of all or any portion of this Option,
execute and deliver to the Company such Investment Representation Statement or such other form as
the Company may request.

     12. Options Terminate if Optionee Violates Agreements. The Participant hereby
acknowledges and agrees, as a condition to receiving a grant of the Options, and the receiving of
Shares upon exercise of such Options, to be bound by the restrictive covenant provisions of that
certain Employment Agreement, dated                     , entered into by and between the Company and the
Participant, as well as any and all restrictive covenant agreements including the Noncompetition
Agreement and the Inventions and Proprietary Rights Assignment and Confidentiality Agreement. In
the event the Participant breaches any of the restrictive covenant
provisions and/or agreements, the Board may, within its sole and absolute discretion and upon
written notice to the Optionee, terminate this Agreement and, consequently (a) the Options
hereunder shall become immediately void and shall no longer have any force any effect, and (b) any

6

 

and all Shares Optionee received pursuant to this Agreement must be returned to the Company
immediately upon demand by the Company upon the Company’s return of the exercise price paid by the
Optionee. The determination as to whether the Executive has breached any of the restrictive
covenant provisions and/or agreements shall be made by the Board, in good faith, and shall be
binding and conclusive on all parties.

     13. Acceleration of Exercisability of Option. Except as otherwise determined by the
Board or the Committee, in its sole and absolute discretion, this Option shall become immediately
exercisable in the event of a Change in Control, or in the event the Committee or the Board
exercises its discretion to cancel the Option pursuant to Sections 6(b) or (c) hereof.

     14. No Right to Continued Employment. Neither the Option nor this Agreement shall
confer upon the Optionee any right to continued employment or service with the Company.

     15. Law Governing. This Agreement shall be governed in accordance with and governed
by the internal laws of the State of Florida.

     16. Incentive Stock Option Treatment. The terms of this Option shall be interpreted
in a manner consistent with the intent of the Company and the Optionee that the Option qualify as
an Incentive Stock Option under Section 422 of the Code. If any provision of the Plan or the
Agreement shall be impermissible in order for the Option to qualify as an Incentive Stock Option,
then the Option shall be construed and enforced as if such provision had never been included in the
Plan or the Option.

     17. Interpretation. The Optionee accepts the Option subject to all the terms and
provisions of the Plan and this Agreement. The undersigned Optionee hereby accepts as binding,
conclusive and final all decisions or interpretations of the Committee upon any questions arising
under the Plan and this Agreement.

     18. Notices. Any notice under this Agreement shall be in writing and shall be deemed
to have been duly given when delivered personally or when deposited in the United States mail,
registered, postage prepaid, and addressed, in the case of the Company, to the Company’s Secretary
at 3425 Stallion Lane, Weston, Florida 33331, or if the Company should move its principal office,
to such principal office, and, in the case of the Optionee, to the Optionee’s last permanent
address as shown on the Company’s records, subject to the right of either party to designate some
other address at any time hereafter in a notice satisfying the requirements of this Section.

     19. Tax Consequences. Set forth below is a brief summary as of the date of this
Option of certain of the federal tax consequences of exercise of this Option and disposition of the
Shares under the law in effect as of the date of grant. THIS SUMMARY IS NECESSARILY INCOMPLETE,
AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO
CHANGE. OPTIONEE SHOULD CONSULT A TAX ADVISER BEFORE EXERCISING THIS OPTION OR DISPOSING OF
THE SHARES.

7

 

     (a) Exercise of Option. There will be no regular federal income tax liability
upon the exercise of the Option, although the excess, if any, of the fair market value of
the Shares on the date of exercise over the Exercise Price will be treated as an adjustment
to the alternative minimum tax for federal tax purposes and may subject the Optionee to the
alternative minimum tax in the year of exercise.

     (b) Disposition of Shares. If Shares transferred pursuant to the Option are
held for at least one year after exercise and are disposed of at least two years after the
Date of Grant, any gain realized on disposition of the Shares will also be treated as
long-term capital gain for federal income tax purposes. If Shares purchased under an
Option are disposed of within such one-year period or within two years after the Date of
Grant, any gain realized on such disposition will be treated as compensation income (taxable
at ordinary income rates) to the extent of the difference between the Exercise Price and the
lesser of (1) the fair market value of the Shares on the date of exercise, or (2) the sale
price of the Shares.

     (c) Notice of Disqualifying Disposition of Option Shares. If the Optionee
sells or otherwise disposes of any of the Shares acquired pursuant to the Option on or
before the later of (1) the date two years after the Date of Grant, (2) the date one year
after the date of exercise, the Optionee shall immediately notify the Company in writing of
such disposition. The Optionee agrees that the Optionee may be subject to the income tax
withholding by the Company on the compensation income recognized by the Optionee from the
early disposition by payment in cash or out of the current earnings paid to the Optionee.

     The foregoing discussion assumes that, and only is applicable if, the fair market value of the
Shares as of the date on which the Option is granted is not less than the Exercise Price. The
Company believes that it has made a good faith effort to determine the fair market value of the
Shares and does not believe that the Exercise Price is less than the fair market value of the
Shares on the Date of Grant. No assurances can be given, however, that the Internal Revenue
Service would not take a contrary position, or that the Internal Revenue Service would not treat
the Option as an Incentive Stock Option for some other reason. If the Exercise Price is determined
to be less than the fair market value of a Share on the Date of Grant, then the Option may be
taxable as a non-qualified option. The holder of a non-qualified option will be treated as having
received compensation income (taxable at ordinary income tax rates) at the time the option is
exercised equal to the excess, if any, of the fair market value of the Shares on the date of
exercise over the Exercise Price. If Shares transferred pursuant to the non-qualified option are
held for at least one year, any gain realized on disposition of the Shares will be treated as
long-term capital gain for federal income tax purposes.

8

 

     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the 18th day of
December.

	 	 	 	 	 
	 	COMPANY:

BIOHEART, INC.

 	 
	 	By:  	/s/
 	 
	 	 	Howard J. Leonhardt, Chief Executive         	 
	 	 	Officer 	 
	 

     Optionee acknowledges receipt of a copy of the Plan and represents that he or she is familiar
with the terms and provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had
an opportunity to obtain the advice of counsel prior to executing this Option, and fully
understands all provisions of the Option.

	 	 	 	 	 
	Dated:                                     	OPTIONEE:

 	 
	 	By:  	 	 
	 	 	Scott Bromley 	 
	 	 	 	 

9

 

	 	 	 	 	 

EXHIBIT A

INVESTMENT REPRESENTATION STATEMENT

	 	 	 	 	 
	PURCHASER	 	:	 	 

	 	 	 	 	 
	COMPANY	 	:	 	BIOHEART, INC.

	 	 	 	 	 
	SECURITY	 	:	 	COMMON STOCK

	 	 	 	 	 
	AMOUNT	 	:	 	 

	 	 	 	 	 
	DATE	 	:	 	 

In connection with the grant and exercise of options to purchase of the above-listed Securities, I,
the Purchaser, represent to the Company the following:

     (a) I am aware of the Company’s business affairs and financial condition, and have acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Securities. I am purchasing these Securities for my own account for investment purposes only
and not with a view to, or for the resale in connection with, any “distribution” thereof for
purposes of the Securities Act of 1933, as amended (the “Securities Act”).

     (b) I understand that the Company’s issuance of the Securities has not been registered under
the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon,
among other things, the bona fide nature of my investment intent as expressed herein. In this
connection, I understand that, in the view of the Securities and Exchange Commission (the “SEC”),
the statutory basis for such exemption may be unavailable if my representation was predicated
solely upon a present intention to hold these Securities for the minimum capital gains period
specified under tax statutes, for a deferred sale, for or until an increase or decrease in the
market price of the Securities, or for a period of one year or any other fixed period in the
future.

     (c) I further understand that the Securities must be held by me indefinitely unless the
transfer is subsequently registered under the Securities Act or unless an exemption from
registration is otherwise available, and that I cannot transfer or sell any Securities unless
permitted under my Stock Option Agreement and the Stockholders Agreement referenced in Section 9(a)
of this Stock Option Agreement. Moreover, I understand that the Company is under no obligation to
register any transfer of the Securities. In addition, I understand that the certificate evidencing
the Securities will be imprinted with a legend which prohibits the transfer of the Securities
unless registered or such registration is not required in the opinion of counsel for the Company.

10

 

     (d) I am familiar and agree to comply with the provisions of Rule 701 and Rule 144, each
promulgated under the Securities Act, which, in substance, permit
limited public resale of “restricted securities” acquired, directly or indirectly, from the issuer thereof, in a
non-public offering subject to the satisfaction of certain conditions, subject to the requirements
of my Stock Option Agreement and the Stockholders Agreement.

	 	 	 	 	 
	 	Signature of Purchaser:

 	 
	 	 	 
	 	 	 
	 	 	 
	 

Date:                               

11

 

EXHIBIT C

BIOHEART, INC.

INCENTIVE STOCK OPTION AGREEMENT

FOR

Scott Bromley

Agreement

     1. Grant of Option. BIOHEART, INC. (the “Company”) hereby grants, as of December 31,
2005 (the “Date of Grant”), to Scott Bromley (the “Optionee”) an option (the “Option”) to purchase
up to 500 shares of the Company’s Common Stock, $.01 par value (the “Stock”), at an exercise price
per share equal to $3.50 (the “Exercise Price”). The Option shall be subject to the terms and
conditions set forth herein. The Option was issued pursuant to the Company’s 1999 Officers and
Employees Stock Option Plan (the “Plan”), which is incorporated herein for all purposes. The
Option shall be treated by the Company as an incentive stock option within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the “Code”) and not a nonqualified stock
option, if and to the extent that the limitations under Section 4(b) of the Plan and Section 422(d)
of the Code, are not exceeded. The Optionee hereby acknowledges receipt of a copy of the Plan and
agrees to be bound by all of the terms and conditions hereof and thereof.

     2. Definitions. Unless otherwise provided herein, terms used herein that are defined
in the Plan and not defined herein shall have the meanings attributed thereto in the Plan.

     3. Exercise Schedule. Except as otherwise provided in Section 6 or 12 of this
Agreement, or in the Plan, the Option is exercisable in installments as provided below, which shall
be cumulative. To the extent that the Option has become exercisable with respect to a percentage of
Shares as provided below, the Option may thereafter be exercised by the Optionee, in whole or in
part, at any time or from time to time prior to the expiration of the Option as provided herein.
The following table indicates each date (the “Vesting Date”) upon which the Optionee shall be
entitled to exercise the Option with respect to the percentage of Shares granted as indicated
beside the date, provided that the Optionee has been continuously employed by the Company or a
Subsidiary through and on the applicable Vesting Date:

	 	 	 
	Percentage of Shares	 	Vesting Date
	 
	 	 
	100%
	 	Immediately

     Except as otherwise specifically provided herein, there shall be no proportionate or partial
vesting in the periods prior to each Vesting Date, and all vesting shall occur only on the
appropriate Vesting Date. Upon the Optionee’s termination of employment with the Company

 

 

and its Subsidiaries, any unvested portion of the Option shall terminate and be null and void.

     4. Method of Exercise. This Option shall be exercisable in whole or in part in
accordance with the exercise schedule set forth in Section 3 hereof by written notice which shall
state the election to exercise the Option, the number of Shares in respect of which the Option is
being exercised, and such other representations and agreements as to the holder’s investment intent
with respect to such Shares as may be required by the Company pursuant to the provisions of the
Plan. Such written notice shall be signed by the Optionee and shall be delivered in person or by
certified mail to the Chief Financial Officer of the Company. The written notice shall be
accompanied by payment of the Exercise Price. This Option shall be deemed to be exercised after
(a) receipt by the Company of such written notice accompanied by the Exercise Price, and (b)
arrangements that are satisfactory to the Board or the Committee in its sole discretion have been
made for Optionee’s payment to the Company of the amount that is necessary to be withheld in
accordance with applicable Federal or state withholding requirements. No Shares will be issued
pursuant to the Option unless and until such issuance and such exercise shall comply with all
relevant provisions of applicable law, including the requirements of any stock exchange upon which
the Stock then may be traded.

     5. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee: (a) cash; (b) check; (c)
with Shares that have been held by the Optionee for at least 6 months (or such other Shares as the
Company determines will not cause the Company to recognize for financial accounting purposes a
charge for compensation expense); or (d) such other consideration or in such other manner as may be
determined by the Board or the Committee in its absolute discretion.

     6. Termination of Option.

     (a) Any unexercised portion of the Option shall automatically and without notice terminate and
become null and void at the time of the earliest to occur of:

          (i) three (3) months after the date on which the Optionee’s employment with the Company and
its Subsidiaries is terminated for any reason other than by reason of (A) Cause, which, solely for
purposes of this Agreement, shall mean the termination of the Optionee’s employment by reason of
the Optionee’s willful misconduct or gross negligence, (B) a mental or physical disability (within
the meaning of Section 22(e) of the Internal Revenue Code of 1986, as amended) of the Optionee as
determined by a medical doctor satisfactory to the Committee, or (C) death;

          (ii) immediately upon the termination of the Optionee’s employment with the Company and its
Subsidiaries for Cause;

          (iii) twelve (12) months after the date on which the Optionee’s employment with the Company
and its Subsidiaries is terminated by reason of a mental or physical disability (within the meaning
of Section 22(e) of the Internal Revenue Code of 1986, as amended) as determined by a medical
doctor satisfactory to the Committee;

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          (iv) twelve (12) months after the date of termination of the Optionee’s employment with the
Company and its Subsidiaries by reason of the death of the Optionee (or if later, three months
after the date on which the Optionee shall die if such death shall occur during the one year period
specified in paragraph (iii) of this Section 6);

          (v) immediately in the event that the Optionee shall file any lawsuit or arbitration claim
against the Company or any Subsidiary, or any of their respective officers, directors or
shareholders of the Company;

          (vi) the tenth (10th) anniversary of the Date of Grant; or

          (vii) termination under Section 12 hereof.

     (b) To the extent not previously exercised, (i) the Option shall terminate immediately in the
event of (1) the liquidation or dissolution of the Company, or (2) any reorganization, merger,
consolidation or other form of corporate transaction in which the Company does not survive, unless
the successor corporation, or a parent or subsidiary of such successor corporation, assumes the
Option or substitutes an equivalent option or right pursuant to Section 10(c) of the Plan, and (ii)
the Committee or the Board in its sole discretion may by written notice (“cancellation notice”)
cancel, effective upon the consummation of any corporate transaction described in Subsection
8(b)(i) of the Plan in which the Company does survive, any Option that remains unexercised on such
date. The Committee or the Board shall give written notice of any proposed transaction referred to
in this Section 6(b) a reasonable period of time prior to the closing date for such transaction
(which notice may be given either before or after approval of such transaction), in order that the
Optionee may have a reasonable period of time prior to the closing date of such transaction within
which to exercise the Option if and to the extent that it then is exercisable (including any
portion of the Option that may become exercisable upon the closing date of such transaction). The
Optionee may condition his exercise of the Option upon the consummation of a transaction referred
to in this Section 6(b).

     7. Transferability. The Option granted hereby is not transferable otherwise than by
will or under the applicable laws of descent and distribution, and during the lifetime of the
Optionee the Option shall be exercisable only by the Optionee or the Optionee’s guardian or legal
representative. In addition, the Option shall not be assigned, negotiated, pledged or hypothecated
in any way (whether by operation of law or otherwise), and the Option shall not be subject to
execution, attachment or similar process. Upon any attempt to transfer, assign, negotiate, pledge
or hypothecate the Option, or in the event of any levy upon the Option by reason of execution,
attachment or similar process contrary to the provisions hereof, the Option shall immediately
become null and void.

     8. No Rights of Stockholders. Neither the Optionee nor any personal representative
(or beneficiary) shall be, or shall have any of the rights and privileges of, a stockholder of the
Company with respect to any shares of Stock purchasable or issuable upon the exercise of the
Option, in whole or in part, prior to the date of exercise of the Option.

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     9. Stockholders Agreements; Restrictions.

     (a) Stockholders Agreement. Unless the requirements under this sentence are waived in
writing by the Company, the Optionee shall not be permitted to exercise the Option or to be issued
any shares of Stock thereunder unless and until the Optionee executes and delivers to the Company
the form of stockholders agreement then in effect among the Company and its stockholders (which
agreement may be the stockholders agreement utilized in connection with the Company’s initial
private offering to investors) (the “Stockholders Agreement”). In addition to any rights or
obligations of Optionee under such Stockholders Agreement, the Optionee is and shall be subject to
the following provisions of this Section 9 and the other provisions of this Option Agreement.

     (b) Restrictions While Stock is Not Registered; Restricted Shares. The shares of
Stock subject to the Option specified in Section 1 and (i) all shares of the Company’s capital
stock received as a dividend or other distribution upon such shares, and (ii) all shares of capital
stock or other securities of the Company into which such shares may be changed or for which such
shares shall be exchanged, whether through reorganization, recapitalization, stock split-ups or the
like, shall be subject to the provisions of this Section 9 at all times, and only at those times,
that shares of the Company’s Common Stock are not Publicly-Held (such times during which the Stock
is not so Publicly-Held hereinafter being referred to as the “Restricted Period”) and are during
the Restricted Period hereinafter referred to as “Restricted Shares.” For purposes of this
Agreement, “Publicly-Held” means that the Common Stock of the Company, or the stock of any
successor company into which the Common Stock is substituted or exchanged, is registered pursuant
to Section 12(b) or 12(g) of the Securities Exchange Act.

     (c) No Sale or Pledge of Restricted Shares. Except as otherwise provided herein, the
Optionee agrees and covenants that during the Restricted Period he or she will not sell, pledge,
encumber or otherwise transfer or dispose of, and will not permit to be sold, encumbered, attached
or otherwise disposed of or transferred in any manner, either voluntarily or by operation of law
(all hereinafter collectively referred to as “transfers”), all or any portion of the Restricted
Shares or any interest therein except in accordance with and subject to the terms of this Section
9.

     (d) Involuntary Transfer Repurchase Option. Whenever, during the Restricted Period,
the Optionee has any notice or knowledge of any attempted, pending, or consummated involuntary
transfer or lien or charge upon any of the Restricted Shares, whether by operation of law or
otherwise, the Optionee shall give immediate written notice thereof to the Company. Whenever the
Company has any other notice or knowledge of any such attempted, impending, or consummated
involuntary transfer, lien, or charge, it shall give written notice thereof to the Optionee. In
either case, the Optionee agrees to disclose forthwith to the Company all pertinent information in
his possession relating thereto. If during the Restricted Period any of the Restricted Shares are
subjected to any such involuntary transfer, lien, or charge, the Company and its designated
purchaser shall at all times have the immediate and continuing option to purchase such of the
Restricted Shares upon notice by the Company to the Optionee or other record holder at a price
determined according to Section 9(f) below, and any of the Restricted Shares so purchased by the
Company or its designated purchaser shall in every case be free and
clear of such transfer, lien, or charge.

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     (e) Repurchase Option on Termination of Employment. Anything set forth in this
Agreement to the contrary notwithstanding, the Company shall have the right (but not the
obligation) to purchase or designate a purchaser of all, but not less than all, of the Restricted
Shares (including, without limitation, any Restricted Shares transferred pursuant to Section 2.3.1
of the Stockholders Agreement) during the Restricted Period and after termination of the Optionee’s
employment relationship with the Company for any reason, for the purchase price specified in
Section 9(f) hereof. The Company may exercise its right to purchase or designate a purchaser of
the Restricted Shares at any time (without any time limitation) after the Optionee’s termination of
employment or service and during the Restricted Period. If the Company chooses to exercise its
right to purchase the Restricted Shares hereunder, the Company shall give its notice of its
exercise of this right to the Optionee or his or her legal representative specifying in such notice
a date not later than ten (10) days following the date of giving such notice on which the Company
or its designated purchaser shall deliver, or be prepared to deliver the check or promissory note
for the purchase price and the Optionee or his or her legal representative shall deliver all stock
certificates evidencing such Restricted Shares duly endorsed in blank for transfer or with separate
stock powers endorsed in blank for transfer.

     (f) Repurchase Price. For purposes of Section 9(d) and (e) hereof, the per share
purchase price of Restricted Shares shall be an amount equal to the Fair Market Value of such
share, determined by the Board or the Committee as of any date determined by the Board or the
Committee that is not more than one year prior to the date of the event giving rise to the
Company’s right to purchase such Restricted Shares under this Section 9. Any determination of Fair
Market Value made by the Board or the Committee shall be binding and conclusive on all parties
unless shown to have been made in an arbitrary and capricious manner. The purchase price shall, at
the option of the Company, be payable in cash or in the form of the Company’s promissory note
payable in up to three equal annual installments commencing 12 months after the acquisition by the
Company (“Acquisition Date”) of the Restricted Shares, together with interest on the unpaid balance
thereof at the rate equal to the prime rate of interest of Citibank, N.A. on the Acquisition Date.

     (g) Voting Rights. As a condition to Optionee’s exercise of any Option pursuant to
this Agreement, the Company may in its discretion require that Optionee enter into a voting
agreement that grants to specified persons designated therein the voting rights for all shares of
Stock acquired pursuant to the exercise of such Options, until the earlier of (i) 10 years from the
date of exercise of the Option, or (ii) the end of the Restricted Period, such voting agreement to
be in such form as the Company reasonably may request.

     (h) Legends. The certificate or certificates representing any Shares acquired
pursuant to the exercise of an Option prior to the last day of the Restricted Period shall bear the
following legends (as well as any legends required by applicable state and federal corporate and
securities laws or the Stockholders Agreement):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE “ACT”)
AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR
HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR, IN THE OPINION OF

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COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE
SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS IN
COMPLIANCE THEREWITH.

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER, RIGHT OF FIRST REFUSAL AND REDEMPTION OR
REPURCHASE OPTIONS HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE
STOCK OPTION AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE
SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE
ISSUER. SUCH TRANSFER RESTRICTIONS, RIGHT OF FIRST REFUSAL AND REDEMPTION
OR REPURCHASE RIGHTS ARE BINDING ON TRANSFEREES OF THESE SHARES.

     10. Market Stand-Off Agreement. In the event of an initial public offering
of the Company’s securities and upon request of the Company or the underwriters managing any
underwritten offering of the Company’s securities, the Optionee agrees not to sell, make any short
sale of, loan, grant any option for the purchase of, or otherwise dispose of any Shares (other than
those included in the registration) acquired pursuant to the exercise of the Option, without the
prior written consent of the Company or such underwriters, as the case may be, for such period of
time (not to exceed 180 days) from the effective date of such registration as may be requested by
the Company or such managing underwriters.

     11. Optionee’s Representations. By executing this Agreement, Optionee hereby
represents and warrants to the Company as to all provisions set forth in the Investment
Representation Statement attached hereto as Exhibit A. In addition, in the event the Company’s
issuance of the Shares purchasable pursuant to the exercise of this Option has not been registered
under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall,
if required by the Company, concurrently with the exercise of all or any portion of this Option,
execute and deliver to the Company such Investment Representation Statement or such other form as
the Company may request.

     12. Options Terminate if Optionee Violates Agreements. The Participant hereby
acknowledges and agrees, as a condition to receiving a grant of the Options, and the receiving of
Shares upon exercise of such Options, to be bound by the restrictive covenant provisions of that
certain Employment Agreement, dated December 25,1999, entered into by and between the Company and
the Participant, as well as any and all restrictive covenant agreements including the
Noncompetition Agreement and the Inventions and Proprietary Rights Assignment and Confidentiality
Agreement. In the event the Participant breaches any of the restrictive covenant provisions and/or
agreements, the Board may, within its sole and absolute discretion and upon written notice to the
Optionee, terminate this Agreement and, consequently (a) the Options

6

 

hereunder shall become immediately void and shall no longer have any force any effect, and (b)
any and all Shares Optionee received pursuant to this Agreement must be returned to the Company
immediately upon demand by the Company upon the Company’s return of the exercise price paid by the
Optionee. The determination as to whether the Executive has breached any of the restrictive
covenant provisions and/or agreements shall be made by the Board, in good faith, and shall be
binding and conclusive on all parties.

     13. Acceleration of Exercisability of Option. Except as otherwise determined by the
Board or the Committee, in its sole and absolute discretion, this Option shall become immediately
exercisable in the event of a Change in Control, or in the event the Committee or the Board
exercises its discretion to cancel the Option pursuant to Sections 6(b) or (c) hereof.

     14. No Right to Continued Employment. Neither the Option nor this Agreement shall
confer upon the Optionee any right to continued employment or service with the Company.

     15. Law Governing. This Agreement shall be governed in accordance with and governed
by the internal laws of the State of Florida.

     16. Incentive Stock Option Treatment. The terms of this Option shall be interpreted
in a manner consistent with the intent of the Company and the Optionee that the Option qualify as
an Incentive Stock Option under Section 422 of the Code. If any provision of the Plan or the
Agreement shall be impermissible in order for the Option to qualify as an Incentive Stock Option,
then the Option shall be construed and enforced as if such provision had never been included in the
Plan or the Option.

     17. Interpretation. The Optionee accepts the Option subject to all the terms and
provisions of the Plan and this Agreement. The undersigned Optionee hereby accepts as binding,
conclusive and final all decisions or interpretations of the Committee upon any questions arising
under the Plan and this Agreement.

     18. Notices. Any notice under this Agreement shall be in writing and shall be deemed
to have been duly given when delivered personally or when deposited in the United States mail,
registered, postage prepaid, and addressed, in the case of the Company, to the Company’s Secretary
at 3425 Stallion Lane, Weston, Florida 33331, or if the Company should move its principal office,
to such principal office, and, in the case of the Optionee, to the Optionee’s last permanent
address as shown on the Company’s records, subject to the right of either party to designate some
other address at any time hereafter in a notice satisfying the requirements of this Section.

     19. Tax Consequences. Set forth below is a brief summary as of the date of this
Option of certain of the federal tax consequences of exercise of this Option and disposition of the
Shares under the law in effect as of the date of grant. THIS SUMMARY IS NECESSARILY INCOMPLETE,
AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. OPTIONEE SHOULD CONSULT A TAX ADVISER
BEFORE EXERCISING THIS OPTION OR DISPOSING OF THE SHARES.

     (a) Exercise of Option. There will be no regular federal income tax liability
upon the exercise of the Option, although the excess, if any, of the fair market value of
the Shares on the date of exercise over the Exercise Price will be treated as an adjustment
to the alternative minimum tax for federal tax purposes and may subject the Optionee to the
alternative minimum tax in the year of exercise.

7

 

     (b) Disposition of Shares. If Shares transferred pursuant to the Option are
held for at least one year after exercise and are disposed of at least two years after the
Date of Grant, any gain realized on disposition of the Shares will also be treated as
long-term capital gain for federal income tax purposes. If Shares purchased under an
Option are disposed of within such one-year period or within two years after the Date of
Grant, any gain realized on such disposition will be treated as compensation income (taxable
at ordinary income rates) to the extent of the difference between the Exercise Price and the
lesser of (1) the fair market value of the Shares on the date of exercise, or (2) the sale
price of the Shares.

     (c) Notice of Disqualifying Disposition of Option Shares. If the Optionee
sells or otherwise disposes of any of the Shares acquired pursuant to the Option on or
before the later of (1) the date two years after the Date of Grant, (2) the date one year
after the date of exercise, the Optionee shall immediately notify the Company in writing of
such disposition. The Optionee agrees that the Optionee may be subject to the income tax
withholding by the Company on the compensation income recognized by the Optionee from the
early disposition by payment in cash or out of the current earnings paid to the Optionee.

     The foregoing discussion assumes that, and only is applicable if, the fair market value of the
Shares as of the date on which the Option is granted is not less than the Exercise Price. The
Company believes that it has made a good faith effort to determine the fair market value of the
Shares and does not believe that the Exercise Price is less than the fair market value of the
Shares on the Date of Grant. No assurances can be given, however, that the Internal Revenue
Service would not take a contrary position, or that the Internal Revenue Service would not treat
the Option as an Incentive Stock Option for some other reason. If the Exercise Price is determined
to be less than the fair market value of a Share on the Date of Grant, then the Option may be
taxable as a non-qualified option. The holder of a non-qualified option will be treated as having
received compensation income (taxable at ordinary income tax rates) at the time the option is
exercised equal to the excess, if any, of the fair market value of the Shares on the date of
exercise over the Exercise Price. If Shares transferred pursuant to the non-qualified option are
held for at least one year, any gain realized on disposition of the Shares will be treated as
long-term capital gain for federal income tax purposes.

8

 

     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the            day of                                .

	 	 	 	 	 
	 	COMPANY:

BIOHEART, INC.

 	 
	 	By:  	/s/
 	 
	 	 	Howard J. Leonhardt 	 
	 	 	CEO & Chairman 	 
	 

     Optionee acknowledges receipt of a copy of the Plan and represents that he or she is familiar
with the terms and provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had
an opportunity to obtain the advice of counsel prior to executing this Option, and fully
understands all provisions of the Option.

	 	 	 	 	 
	Dated:                                      	OPTIONEE:

 	 
	 	By:  	/s/
 	 
	 	 	Scott Bromley 	 
	 	 	 	 

9

 

	 	 	 	 	 

EXHIBIT A

INVESTMENT REPRESENTATION STATEMENT

	 	 	 	 	 
	PURCHASER	 	:	 	Scott Bromley

	 	 	 	 	 
	COMPANY	 	:	 	BIOHEART, INC.

	 	 	 	 	 
	SECURITY	 	:	 	COMMON STOCK

	 	 	 	 	 
	AMOUNT	 	:	 	500

	 	 	 	 	 
	DATE	 	:	 	December 31, 2005

In connection with the grant and exercise of options to purchase of the above-listed Securities, I,
the Purchaser, represent to the Company the following:

     (a) I am aware of the Company’s business affairs and financial condition, and have acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Securities. I am purchasing these Securities for my own account for investment purposes only
and not with a view to, or for the resale in connection with, any “distribution” thereof for
purposes of the Securities Act of 1933, as amended (the “Securities Act”).

     (b) I understand that the Company’s issuance of the Securities has not been registered under
the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon,
among other things, the bona fide nature of my investment intent as expressed herein. In this
connection, I understand that, in the view of the Securities and Exchange Commission (the “SEC”),
the statutory basis for such exemption may be unavailable if my representation was predicated
solely upon a present intention to hold these Securities for the minimum capital gains period
specified under tax statutes, for a deferred sale, for or until an increase or decrease in the
market price of the Securities, or for a period of one year or any other fixed period in the
future.

     (c) I further understand that the Securities must be held by me indefinitely unless the
transfer is subsequently registered under the Securities Act or unless an exemption from
registration is otherwise available, and that I cannot transfer or sell any Securities unless
permitted under my Stock Option Agreement and the Stockholders Agreement referenced in Section 9(a)
of this Stock Option Agreement. Moreover, I understand that the Company is under no obligation to
register any transfer of the Securities. In addition, I understand that the certificate evidencing
the Securities will be imprinted with a legend which prohibits the transfer of the Securities
unless registered or such registration is not required in the opinion of counsel for the Company.

10

 

     (d) I am familiar and agree to comply with the provisions of Rule 701 and Rule 144, each
promulgated under the Securities Act, which, in substance, permit limited public resale of
“restricted securities” acquired, directly or indirectly, from the issuer thereof, in a
non-public offering subject to the satisfaction of certain conditions, subject to the requirements
of my Stock Option Agreement and the Stockholders Agreement.

	 	 	 	 	 
	 	Signature of Purchaser:

 	 
	 	 	 
	 	Scott Bromley 	 
	 	 	 
	 

Date:                               

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EXHIBIT D

BIOHEART, INC.

INCENTIVE STOCK OPTION AGREEMENT

FOR

SCOTT BROMLEY

Agreement

     1. Grant of Option. BIOHEART, INC. (the “Company”) hereby grants, as of August ___,
2006 (the “Date of Grant”), to Scott Bromley (the “Optionee”) an option (the “Option”) to purchase
up to 458,000 shares of the Company’s Common Stock, $.01 par value (the “Stock”), at an exercise
price per share equal to $3.50 (the “Exercise Price”). The Option shall be subject to the terms
and conditions set forth herein. The Option was issued pursuant to the Company’s 1999 Officers and
Employees Stock Option Plan (the “Plan”), which is incorporated herein for all purposes. The
Option shall be treated by the Company as an incentive stock option within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the “Code”) and not a nonqualified stock
option, if and to the extent that the limitations under Section 4(b) of the Plan and Section 422(d)
of the Code, are not exceeded. The Optionee hereby acknowledges receipt of a copy of the Plan and
agrees to be bound by all of the terms and conditions hereof and thereof.

     2. Definitions. Unless otherwise provided herein, terms used herein that are defined
in the Plan and not defined herein shall have the meanings attributed thereto in the Plan.

     3. Exercise Schedule. Except as otherwise provided in Section 6 or 12 of this
Agreement, or in the Plan, the Option is fully vested and exercisable as of the Date of Grant and
may be exercised by the Optionee, in whole or in part, at any time or from time to time prior to
the expiration of the Option as provided herein.

     4. Method of Exercise. This Option shall be exercisable in whole or in part by
written notice which shall state the election to exercise the Option, the number of Shares in
respect of which the Option is being exercised, and such other representations and agreements as to
the holder’s investment intent with respect to such Shares as may be required by the Company
pursuant to the provisions of the Plan. Such written notice shall be signed by the Optionee and
shall be delivered in person or by certified mail to the Chief Financial Officer of the Company.
The written notice shall be accompanied by payment of the Exercise Price. This Option shall be
deemed to be exercised after (a) receipt by the Company of such written notice accompanied by the
Exercise Price, and (b) arrangements that are satisfactory to the Board or the Committee in its
sole discretion have been made for Optionee’s payment to the Company of the amount that is
necessary to be withheld in accordance with applicable Federal or state withholding requirements.
No Shares will be issued pursuant to the Option unless and until such issuance and such exercise
shall comply with all relevant provisions of applicable law, including the requirements of any
stock exchange upon which the Stock then may be traded.

     5. Method of Payment. Payment of the exercise price shall be by any of the
following, or a combination thereof, at the election of the Optionee: (a) cash; (b) check; (c)
with Shares that have been held by the Optionee for at least 6 months (or such other Shares as the

 

 

Company determines will not cause the Company to recognize for financial accounting purposes a
charge for compensation expense); or (d) such other consideration or in such other manner as may be
determined by the Board or the Committee in its absolute discretion.

     6. Termination of Option.

     (a) Any unexercised portion of the Option shall automatically and without notice terminate and
become null and void on the Tenth (10th) anniversary of the date of grant.

     (b) To the extent not previously exercised, (i) the Option shall terminate immediately in the
event of (1) the liquidation or dissolution of the Company, or (2) any reorganization, merger,
consolidation or other form of corporate transaction in which the Company does not survive, unless
the successor corporation, or a parent or subsidiary of such successor corporation, assumes the
Option or substitutes an equivalent option or right pursuant to Section 10(c) of the Plan, and (ii)
the Committee or the Board in its sole discretion may by written notice (“cancellation notice”)
cancel, effective upon the consummation of any corporate transaction described in Subsection
8(b)(i) of the Plan in which the Company does survive, any Option that remains unexercised on such
date. The Committee or the Board shall give written notice of any proposed transaction referred to
in this Section 6(b) a reasonable period of time prior to the closing date for such transaction
(which notice may be given either before or after approval of such transaction), in order that the
Optionee may have a reasonable period of time prior to the closing date of such transaction within
which to exercise the Option if and to the extent that it then is exercisable (including any
portion of the Option that may become exercisable upon the closing date of such transaction). The
Optionee may condition his exercise of the Option upon the consummation of a transaction referred
to in this Section 6(b).

     (c) To the extent not previously exercised, the Option shall terminate immediately in the
event the Optionee’s employment with the Company is terminated for Cause. For purposes of this
agreement, “Cause” shall mean (i) the Optionee commits a felonious act or is convicted of a
misdemeanor which is related to the Optionee’s employment or the business of the Company; (ii) the
Optionee, in carrying out his employment duties, has acted with gross negligence or intentional
misconduct resulting, in either case, in harm to the Company; (iii) the Optionee misappropriates
Company funds or otherwise defrauds the Company; (iv) the Optionee breaches his fiduciary duty to
the Company resulting in profit to him, directly or indirectly; or (v) the Optionee materially
breaches any agreement with the Company.

     7. Transferability. The Option granted hereby is not transferable otherwise than by
will or under the applicable laws of descent and distribution, and during the lifetime of the
Optionee the Option shall be exercisable only by the Optionee or the Optionee’s guardian or legal
representative. In addition, the Option shall not be assigned, negotiated, pledged or hypothecated
in any way (whether by operation of law or otherwise), and the Option shall not be subject to
execution, attachment or similar process. Upon any attempt to transfer, assign, negotiate, pledge
or hypothecate the Option, or in the event of any levy upon the Option by reason of execution,
attachment or similar process contrary to the provisions hereof, the Option shall immediately
become null and void.

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     8. No Rights of Stockholders. Neither the Optionee nor any personal representative
(or beneficiary) shall be, or shall have any of the rights and privileges of, a stockholder of the
Company with respect to any shares of Stock purchasable or issuable upon the exercise of the
Option, in whole or in part, prior to the date of exercise of the Option.

     9. Stockholders Agreements; Restrictions.

     (a) Stockholders Agreement. Unless the requirements under this sentence are waived in
writing by the Company, the Optionee shall not be permitted to exercise the Option or to be issued
any shares of Stock thereunder unless and until the Optionee executes and delivers to the Company
the form of stockholders agreement then in effect among the Company and its stockholders (which
agreement may be the stockholders agreement utilized in connection with the Company’s initial
private offering to investors) (the “Stockholders Agreement”). In addition to any rights or
obligations of Optionee under such Stockholders Agreement, the Optionee is and shall be subject to
the following provisions of this Section 9 and the other provisions of this Option Agreement.

     (b) Restrictions While Stock is Not Registered; Restricted Shares. The shares of
Stock subject to the Option specified in Section 1 and (i) all shares of the Company’s capital
stock received as a dividend or other distribution upon such shares, and (ii) all shares of capital
stock or other securities of the Company into which such shares may be changed or for which such
shares shall be exchanged, whether through reorganization, recapitalization, stock split-ups or the
like, shall be subject to the provisions of this Section 9 at all times, and only at those times,
that shares of the Company’s Common Stock are not Publicly-Held (such times during which the Stock
is not so Publicly-Held hereinafter being referred to as the “Restricted Period”) and are during
the Restricted Period hereinafter referred to as “Restricted Shares.” For purposes of this
Agreement, “Publicly-Held” means that the Common Stock of the Company, or the stock of any
successor company into which the Common Stock is substituted or exchanged, is registered pursuant
to Section 12(b) or 12(g) of the Securities Exchange Act.

     (c) No Sale or Pledge of Restricted Shares. Except as otherwise provided herein, the
Optionee agrees and covenants that during the Restricted Period he or she will not sell, pledge,
encumber or otherwise transfer or dispose of, and will not permit to be sold, encumbered, attached
or otherwise disposed of or transferred in any manner, either voluntarily or by operation of law
(all hereinafter collectively referred to as “transfers”), all or any portion of the Restricted
Shares or any interest therein except in accordance with and subject to the terms of this Section
9.

     (d) Involuntary Transfer Repurchase Option. Whenever, during the Restricted Period,
the Optionee has any notice or knowledge of any attempted, pending, or consummated involuntary
transfer or lien or charge upon any of the Restricted Shares, whether by operation of law or
otherwise, the Optionee shall give immediate written notice thereof to the Company. Whenever the
Company has any other notice or knowledge of any such attempted, impending, or consummated
involuntary transfer, lien, or charge, it shall give written notice thereof to the Optionee. In
either case, the Optionee agrees to disclose forthwith to the Company all pertinent information in
his possession relating thereto. If during the Restricted Period any of the

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Restricted Shares are subjected to any such involuntary transfer, lien, or charge, the Company and
its designated purchaser shall at all times have the immediate and continuing option to purchase
such of the Restricted Shares upon notice by the Company to the Optionee or other record holder at
a price determined according to Section 9(f) below, and any of the Restricted Shares so purchased
by the Company or its designated purchaser shall in every case be free and clear of such transfer,
lien, or charge.

     (e) Repurchase Option on Termination of Employment. Anything set forth in this
Agreement to the contrary notwithstanding, the Company shall have the right (but not the
obligation) to purchase or designate a purchaser of all, but not less than all, of the Restricted
Shares (including, without limitation, any Restricted Shares transferred pursuant to Section 2.3.1
of the Stockholders Agreement) during the Restricted Period and after termination of the Optionee’s
employment relationship with the Company for any reason, for the purchase price specified in
Section 9(f) hereof. The Company may exercise its right to purchase or designate a purchaser of
the Restricted Shares at any time (without any time limitation) after the Optionee’s termination of
employment or service and during the Restricted Period. If the Company chooses to exercise its
right to purchase the Restricted Shares hereunder, the Company shall give its notice of its
exercise of this right to the Optionee or his or her legal representative specifying in such notice
a date not later than ten (10) days following the date of giving such notice on which the Company
or its designated purchaser shall deliver, or be prepared to deliver the check or promissory note
for the purchase price and the Optionee or his or her legal representative shall deliver all stock
certificates evidencing such Restricted Shares duly endorsed in blank for transfer or with separate
stock powers endorsed in blank for transfer.

     (f) Repurchase Price. For purposes of Section 9(d) and (e) hereof, the per share
purchase price of Restricted Shares shall be an amount equal to the Fair Market Value of such
share, determined by the Board or the Committee as of any date determined by the Board or the
Committee that is not more than one year prior to the date of the event giving rise to the
Company’s right to purchase such Restricted Shares under this Section 9. Any determination of Fair
Market Value made by the Board or the Committee shall be binding and conclusive on all parties
unless shown to have been made in an arbitrary and capricious manner. The purchase price shall, at
the option of the Company, be payable in cash or in the form of the Company’s promissory note
payable in up to three equal annual installments commencing 12 months after the acquisition by the
Company (“Acquisition Date”) of the Restricted Shares, together with interest on the unpaid balance
thereof at the rate equal to the prime rate of interest of Citibank, N.A. on the Acquisition Date.

     (g) Voting Rights. As a condition to Optionee’s exercise of any Option pursuant to
this Agreement, the Company may in its discretion require that Optionee enter into a voting
agreement that grants to specified persons designated therein the voting rights for all shares of
Stock acquired pursuant to the exercise of such Options, until the earlier of (i) 10 years from the
date of exercise of the Option, or (ii) the end of the Restricted Period, such voting agreement to
be in such form as the Company reasonably may request.

     (h) Legends. The certificate or certificates representing any Shares acquired
pursuant to the exercise of an Option prior to the last day of the Restricted Period shall bear the
following
legends (as well as any legends required by applicable state and federal corporate and securities
laws or the Stockholders Agreement):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE

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TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE
ACT OR, IN THE OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE
ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR
HYPOTHECATION IS IN COMPLIANCE THEREWITH.

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO CERTAIN
RESTRICTIONS ON TRANSFER, RIGHT OF FIRST REFUSAL AND REDEMPTION OR
REPURCHASE OPTIONS HELD BY THE ISSUER OR ITS ASSIGNEE(S) AS SET FORTH IN THE
STOCK OPTION AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE
SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE
ISSUER. SUCH TRANSFER RESTRICTIONS, RIGHT OF FIRST REFUSAL AND REDEMPTION
OR REPURCHASE RIGHTS ARE BINDING ON TRANSFEREES OF THESE SHARES.

     10. Market Stand-Off Agreement. In the event of an initial public offering of the
Company’s securities and upon request of the Company or the underwriters managing any underwritten
offering of the Company’s securities, the Optionee agrees not to sell, make any short sale of,
loan, grant any option for the purchase of, or otherwise dispose of any Shares (other than those
included in the registration) acquired pursuant to the exercise of the Option, without the prior
written consent of the Company or such underwriters, as the case may be, for such period of time
(not to exceed 180 days) from the effective date of such registration as may be requested by the
Company or such managing underwriters.

     11. Optionee’s Representations. By executing this Agreement, Optionee hereby
represents and warrants to the Company as to all provisions set forth in the Investment
Representation Statement attached hereto as Exhibit A. In addition, in the event the Company’s
issuance of the Shares purchasable pursuant to the exercise of this Option has not been registered
under the Securities Act of 1933, as amended, at the time this Option is exercised, Optionee shall,
if required by the Company, concurrently with the exercise of all or any portion of this Option,
execute and deliver to the Company such Investment Representation Statement or such other form as
the Company may request.

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     12. Options Terminate if Optionee Violates Agreements. The Optionee hereby
acknowledges and agrees, as a condition to receiving a grant of the Options, and the receiving of
Shares upon exercise of such Options, to be bound by the restrictive covenant provisions of any and
all restrictive covenant agreements between Optionee and the Company including, without
limitation, the Noncompetition Agreement and the Inventions and Proprietary Rights Assignment
and Confidentiality Agreement. In the event the Optionee breaches any of the restrictive covenant
provisions and/or agreements, the Board may, within its sole and absolute discretion and upon
written notice to the Optionee, terminate this Agreement and, consequently (a) the Options
hereunder shall become immediately void and shall no longer have any force any effect, and (b) any
and all Shares Optionee received pursuant to this Agreement must be returned to the Company
immediately upon demand by the Company upon the Company’s return of the exercise price paid by the
Optionee. The determination as to whether Optionee has breached any of the restrictive covenant
provisions and/or agreements shall be made by the Board, in good faith, and shall be binding and
conclusive on all parties.

     13. Acceleration of Exercisability of Option. Except as otherwise determined by the
Board or the Committee, in its sole and absolute discretion, this Option shall become immediately
exercisable in the event of a Change in Control, or in the event the Committee or the Board
exercises its discretion to cancel the Option pursuant to Sections 6(b) or (c) hereof.

     14. No Right to Continued Employment. Neither the Option nor this Agreement shall
confer upon the Optionee any right to continued employment or service with the Company.

     15. Law Governing. This Agreement shall be governed in accordance with and governed
by the internal laws of the State of Florida.

     16. Incentive Stock Option Treatment. The terms of this Option shall be interpreted
in a manner consistent with the intent of the Company and the Optionee that the Option qualify as
an Incentive Stock Option under Section 422 of the Code. If any provision of the Plan or the
Agreement shall be impermissible in order for the Option to qualify as an Incentive Stock Option,
then the Option shall be construed and enforced as if such provision had never been included in the
Plan or the Option.

     17. Interpretation. The Optionee accepts the Option subject to all the terms and
provisions of the Plan and this Agreement. The undersigned Optionee hereby accepts as binding,
conclusive and final all decisions or interpretations of the Committee upon any questions arising
under the Plan and this Agreement.

     18. Notices. Any notice under this Agreement shall be in writing and shall be deemed
to have been duly given when delivered personally or when deposited in the United States mail,
registered, postage prepaid, and addressed, in the case of the Company, to the Company’s Secretary
at 13794 NW 4th Street, Suite 212 Sunrise, Florida 33325, or if the Company should move
its principal office, to such principal office, and, in the case of the Optionee, to the Optionee’s
last permanent address as shown on the Company’s records, subject to the right of either party to
designate some other address at any time hereafter in a notice satisfying the requirements of this
Section.

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     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the            day of August
2006.

	 	 	 	 	 
	 	COMPANY:

BIOHEART, INC.

 	 
	 	By:  	/s/
 	 
	 	 	Howard J. Leonhardt 	 
	 	 	Chairman and Chief Executive Officer 	 
	 

     Optionee acknowledges receipt of a copy of the Plan and represents that he or she is familiar
with the terms and provisions thereof, and hereby accepts this Option subject to all of the terms
and provisions thereof. Optionee has reviewed the Plan and this Option in their entirety, has had
an opportunity to obtain the advice of counsel prior to executing this Option, and fully
understands all provisions of the Option.

	 	 	 	 	 
	Dated:                                      	OPTIONEE:

 	 
	 	By:  	/s/
 	 
	 	 	Scott Bromley 	 
	 	 	 	 

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EXHIBIT A

INVESTMENT REPRESENTATION STATEMENT

	 	 	 	 	 
	PURCHASER	 	:	 	Scott Bromley

	 	 	 	 	 
	COMPANY	 	:	 	BIOHEART, INC.

	 	 	 	 	 
	SECURITY	 	:	 	COMMON STOCK

	 	 	 	 	 
	AMOUNT	 	:	 	458,000

	 	 	 	 	 
	DATE	 	:	 	August           , 2006

In connection with the grant and exercise of options to purchase of the above-listed Securities, I,
the Purchaser, represent to the Company the following:

     (a) I am aware of the Company’s business affairs and financial condition, and have acquired
sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Securities. I am purchasing these Securities for my own account for investment purposes only
and not with a view to, or for the resale in connection with, any “distribution” thereof for
purposes of the Securities Act of 1933, as amended (the “Securities Act”).

     (b) I understand that the Company’s issuance of the Securities has not been registered under
the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon,
among other things, the bona fide nature of my investment intent as expressed herein. In this
connection, I understand that, in the view of the Securities and Exchange Commission (the “SEC”),
the statutory basis for such exemption may be unavailable if my representation was predicated
solely upon a present intention to hold these Securities for the minimum capital gains period
specified under tax statutes, for a deferred sale, for or until an increase or decrease in the
market price of the Securities, or for a period of one year or any other fixed period in the
future.

     (c) I further understand that the Securities must be held by me indefinitely unless the
transfer is subsequently registered under the Securities Act or unless an exemption from
registration is otherwise available, and that I cannot transfer or sell any Securities unless
permitted under my Stock Option Agreement and the Stockholders Agreement referenced in Section 9(a)
of this Stock Option Agreement. Moreover, I understand that the Company is under no obligation to
register any transfer of the Securities. In addition, I understand that the certificate evidencing
the Securities will be imprinted with a legend which prohibits the transfer of the Securities
unless registered or such registration is not required in the opinion of counsel for the Company.

8

 

     (d) I am familiar and agree to comply with the provisions of Rule 701 and Rule 144, each
promulgated under the Securities Act, which, in substance, permit limited public resale of
“restricted securities” acquired, directly or indirectly, from the issuer thereof, in a non-public
offering subject to the satisfaction of certain conditions, subject to the requirements of my
Stock Option Agreement and the Stockholders Agreement.

	 	 	 	 	 
	 	Signature of Purchaser:

 	 
	 	 	 
	 	Scott Bromley 	 
	 	 	 
	 

Date:                               

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EXHIBIT E

THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS (THE
“SECURITIES LAWS”), AND MAY NOT BE OFFERED FOR SALE, SOLD, ASSIGNED, TRANSFERRED OR OTHERWISE
DISPOSED OF, UNLESS REGISTERED PURSUANT TO THE PROVISIONS OF THE SECURITIES LAWS OR AN OPINION OF
COUNSEL SATISFACTORY TO THE COMPANY IS OBTAINED TO THE EFFECT THAT SUCH DISPOSITION IS IN
COMPLIANCE WITH AN AVAILABLE EXEMPTION FROM SUCH REGISTRATION, AND ONLY IF OTHERWISE PERMITTED
UNDER THE TERMS OF THIS WARRANT.

Bioheart, Inc.

(a Florida corporation)

August           , 2006

Warrant Certificate for the Purchase of Shares of Common Stock

Not Transferable or Exercisable

Except as Specified Herein

Void After Expiration Date

     THIS CERTIFIES, that, for value received from Scott Bromley (the “Holder”), Bioheart,
Inc., a Florida corporation (the “Company”) hereby grants to Holder, subject to the terms,
provisions and conditions of this Warrant, the right to purchase from the Company up to Three
Hundred and Five Thousand (305,000) fully paid and non-assessable shares of Common Stock (as
defined hereinbelow), of the Company, at a price of Three Dollars and Fifty Cents ($3.50) per share
(the “Exercise Price”), payable in cash; provided, however, that the number
of shares of Common Stock purchasable pursuant to this Warrant and the Exercise Price are subject
to adjustment pursuant to the terms hereof. .

     The term “Common Stock” as used herein shall mean the Common Stock, par value $.001 per share,
of the Company as constituted on August ___, 2006 (the “Base Date”). The shares of Common Stock
deliverable upon the exercise of this Warrant, and as adjusted from time to time, are hereinafter
referred to as “Warrant Stock.” The term “Other Securities” as used herein shall mean any other
equity or debt securities that may be issued by the Company in addition to or in substitution for
the Warrant Stock as provided herein.

     The Holder agrees with the Company that this Warrant is issued, and all the rights hereunder
shall be, subject to, the conditions, limitations and provisions set forth herein.

1

 

     1. Exercise of Warrant.

          1.1. Exercise Period. This Warrant may be exercised, in whole or in part, at any
time, pursuant to the procedures and subject to the terms, conditions and limitations provided
herein, during the period from the Base Date until August ___, 2016 (the “Expiration Date”), but
in no event shall the total aggregate number of shares of Common Stock purchased hereunder exceed
305,000. From and after the Expiration Date, this Warrant shall be void and the Holder shall have
no rights hereunder.

          1.2. Manner of Exercise. This Warrant may be exercised, in whole or in part, at any
time on or before the Expiration Date, and solely in accordance with the procedures, terms,
conditions and limitations provided herein. To exercise this Warrant, the Holder shall present and
surrender this Warrant to the Company at its principal executive office, with the Warrant Exercise
Form attached hereto duly executed by the Holder and accompanied by payment (in the form of either
cash or official bank check, made payable to the order of the Company), of the aggregate Exercise
Price for the total aggregate number of shares specified in such form, duly executed by the Holder
and in form satisfactory to the Company, for which this Warrant is exercised. If this Warrant
should be exercised in part only, the Company shall, upon surrender of this Warrant for
cancellation in connection with such exercise, execute and deliver a new Warrant of like form,
tenor and terms evidencing the rights of the Holder thereof to purchase the balance of the shares
of Warrant Stock purchasable hereunder. Upon receipt by the Company of this Warrant, together with
the duly executed Warrant Exercise Form and payment of the Exercise Price for the shares to be
acquired, in proper form for exercise, and subject to the Holder’s compliance with all requirements
of this Warrant for the exercise hereof, the Holder shall be deemed to be the holder of record of
the shares of Common Stock (or Other Securities) issuable upon such exercise, notwithstanding that
the stock transfer books of the Company shall then be closed or that certificates representing such
shares of Common Stock shall not then be actually delivered to the Holder; provided,
however, that no exercise of this Warrant shall be effective, and the Company shall have no
obligation to issue any Common Stock or Other Securities to the Holder upon any attempted exercise
of this Warrant, unless (A) the Holder shall have first delivered to the Company appropriate
investment representations, in form and substance reasonably satisfactory to the Company, such as
those delineated in Exhibit A hereto, so as to provide the Company with proper assurances that the
securities issuable upon exercise hereof may be issued without violation of the registration
requirements of the Securities Act of 1933, as amended (including the rules and regulations
promulgated thereunder, the “Securities Act”) and all applicable state securities or “blue
sky” laws (the “Securities Laws); including without limitation representations that the
exercising Holder is an “accredited investor” as defined in Regulation D under the Securities Act
and that the Holder is familiar with the Company and its business and financial condition and has
had an opportunity to ask questions and receive documents relating thereto to Holder’s reasonable
satisfaction (and by the Holder’s execution and delivery of this Warrant the Holder hereby makes
such representations (including those on Exhibit “A” hereto) to the Company in connection with the
Holder’s acquisition of this Warrant) and (B) if requested by the Company and if the Company’s
Common Stock is not then publicly traded on any recognized securities exchange or over-the-counter
market, the Holder shall execute and deliver to the Company a shareholders agreement (in the
capacity as a

2

 

shareholder thereunder) in such form as other shareholders who purchased shares of the Company
in its private offering may then be subject (the “Shareholders Agreement”).

          1.3 Termination of Warrant. To the extent not previously exercised, this Warrant
shall terminate immediately and the Holder shall have no rights hereunder in the event the Holder’s
employment with the Company is terminated for Cause. For purposes of this agreement, “Cause” shall
mean (i) the Holder commits a felonious act or is convicted of a misdemeanor which is related to
the Holder’s employment or the business of the Company; (ii) the Holder, in carrying out his
employment duties, has acted with gross negligence or intentional misconduct resulting, in either
case, in harm to the Company; (iii) the Holder misappropriates Company funds or otherwise defrauds
the Company; (iv) the Holder breaches his fiduciary duty to the Company resulting in profit to him,
directly or indirectly; or (v) the Holder materially breaches the Inventions and Proprietary Rights
Assignment and Confidentiality Agreement and Noncompetition Agreement with the Company.

     2. Reservation of Shares. The Company will at all times reserve for issuance and
delivery upon exercise of this Warrant a proper and sufficient number of shares of Common Stock (or
Other Securities) from time to time receivable by the Holder upon the exercise of this Warrant.
All such shares (and Other Securities) shall be duly authorized and, when issued and delivered upon
such exercise in accordance with the terms and provisions hereof, shall be validly issued, fully
paid and non-assessable shares (or Other Securities) of the Corporation.

     3. Fractional Shares. Notwithstanding anything to the contrary herein, the Company
shall not be required to issue certificates representing fractions of shares of Common Stock (or
Other Securities) upon the exercise of this Warrant, nor shall it be required to issue scrip or pay
cash in lieu of fractional interests, it being the intent of the parties that all fractional
interests shall be eliminated by requiring the Holder to make the appropriate payment to purchase
whole shares of Common Stock (or Other Securities).

     4. Assignment or Loss of Warrant. Subject to the transfer restrictions herein
(including Sections 7, 8 and 9, and the notice paragraph at the top of the first page of this
Warrant which is incorporated herein), upon surrender of this Warrant to the Company or at the
office of its stock transfer agent, if any, with the Assignment Form annexed hereto duly executed
and funds sufficient to pay any transfer tax (and any required legal opinion), the Company shall,
without charge, execute and deliver a new Warrant of like tenor in the name of the assignee named
in such instrument of assignment and this Warrant shall promptly be canceled. Upon receipt by the
Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of
this Warrant, and of reasonably satisfactory indemnification by the Holder, and reimbursement to
the Company of all reasonable expenses incidental thereto, and upon surrender and cancellation of
this Warrant, if mutilated, the Company shall execute and deliver a replacement Warrant of like
tenor and date, in lieu hereof.

     5. Rights of the Holder. Notwithstanding any term or provision of this Agreement,
prior to and until such time as the Holder has properly exercised this Warrant as provided herein
and thereupon has become the holder of shares of Common Stock (or Other Securities), the Holder
shall not, by virtue of any provision of this Agreement, be entitled to any rights,

3

 

entitlements or benefits of a shareholder of the Company, either at law or in equity,
including, without limitation, the rights, entitlements and benefits as a shareholder to (a) vote
on or consent with regard to any proposed action of or regarding the Company, or (b) receive (i)
dividends or any other distributions made to shareholders, (ii) notice of or the right to attend
any meeting(s) of shareholders of the Company, or (iii) notice of any other proceedings of or
regarding the Company. The rights of the Holder are limited to those expressed in this Warrant.

     6. Anti-Dilution Provisions.

          6.1. Adjustment for Stock Splits and Certain Other Transactions. If the Company shall
at any time after the Base Date and prior to the Expiration Date subdivide its outstanding shares
of Common Stock (or Other Securities at the time receivable upon the exercise of the Warrant) by
recapitalization, reclassification or split-up thereof, or if the Company shall distribute shares
of Common Stock to its shareholders, the number of shares of Common Stock (or such Other
Securities) subject to this Warrant immediately prior to such stock dividend or subdivision shall
be appropriately and proportionately increased as provided in this paragraph below, and if the
Company shall at any time after the Base Date and prior to the Expiration Date combine the
outstanding shares of Common Stock by recapitalization, reclassification or combination thereof,
the number of shares of Common Stock subject to this Warrant immediately prior to such combination
shall be appropriately and proportionately decreased as provided in this paragraph below. Any such
adjustment, and any related adjustment to the Exercise Price, pursuant to this Section 6.1 shall be
effective at the close of business on the effective date of such subdivision or combination or if
any adjustment is the result of a stock dividend or distribution then the effective date for such
adjustment based thereon shall be the record date therefor. Whenever the number of shares of Common
Stock purchasable upon the exercise of this Warrant is to be adjusted as provided in this paragraph
above, such adjustment shall be made by multiplying the number of shares then subject to issuance
under this Warrant by a fraction (x) the numerator of which shall be the number of shares of Common
Stock outstanding immediately after the event for which such adjustment is to made, and (y) the
denominator of which shall be the number of shares of Common Stock outstanding immediately prior to
such event.

          Whenever the number of shares of Common Stock purchasable upon the exercise of this Warrant is
adjusted, as provided in this Section 6.1, the Exercise Price shall be adjusted to the nearest cent
by multiplying such Exercise Price immediately prior to such adjustment by a fraction (x) the
numerator of which shall be the number of shares of Common Stock purchasable upon the exercise
immediately prior to such adjustment, and (y) the denominator of which shall be the number of
shares of Common Stock so purchasable immediately thereafter. Any adjustment under Section 6 of
this Warrant determined in good faith by the Company’s board of directors shall be final and
binding upon the Holder.

          6.2. Adjustment for Reorganization, Consolidation, Merger, Etc. In case of any
reorganization or recapitalization of the Company (or any other corporation, the securities of
which are at the time receivable on the exercise of this Warrant) after the Base Date and prior to
the Expiration Date or in case during such period the Company (or any such other corporation) shall
consolidate with or merge into another corporation or convey all or substantially all of its

4

 

assets to another corporation, then, and in each such case, the Holder of this Warrant upon
the exercise thereof as provided in Article 1 at any time after the consummation of such
reorganization, consolidation, merger or conveyance, shall be entitled to receive, in lieu of the
securities and property receivable upon the exercise of this Warrant prior to such consummation,
the securities or property to which such Holder would have been entitled upon such consummation if
such Holder had exercised this Warrant immediately prior thereto; in each such case, the terms of
this Warrant shall be applicable to the securities or property receivable upon the exercise of this
Warrant after such consummation.

     7. Restrictions on Transfer of Warrant and Warrant Stock. In addition to any other
requirements of this Warrant, (a) neither this Warrant nor any rights or interest of the Holder
hereunder, may be sold, assigned, transferred, pledged, hypothecated or otherwise disposed of (in
any such case, “Transferred”) without the prior written consent of the Company; which consent may
be withheld in the Company’s sole discretion, and (b) if the Holder is then a party (or required
under Section 1.2 to be a party) to the Shareholders Agreement, neither any Warrant Stock nor Other
Securities may be Transferred unless permitted under the terms of the Shareholders Agreement.

     8. Legends Upon Issued Shares. Unless the shares of Warrant Stock or Other Securities
have been registered under the Securities Act, upon exercise of this Warrant and the issuance of
any of the shares of Warrant Stock, all certificates representing such shares shall bear
substantially the following legend:

     The securities represented by this certificate have not been
registered under the Securities Act of 1933, as amended, and may not
be sold, offered for sale, assigned, transferred or otherwise
disposed of, unless registered pursuant to the provisions of that
Act and applicable state securities laws or unless an opinion of
counsel to the Corporation is obtained stating that such disposition
is in compliance with an available exemption from such registration.

     9. Assignment. This Warrant and all of the terms, provisions and conditions hereof
shall be binding upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns, but neither this Warrant nor any of the rights, benefits,
interests or obligations hereunder shall be assigned or delegated by Holder without the prior
written consent of the Company.

     10. Notices. All notices required hereunder shall be in writing and shall be deemed
given when telegraphed, delivered personally or three days after mailing when mailed by certified
or registered mail, return receipt requested, to the Company or the Holder, as the case may be, for
whom such notice is intended, if to the Holder, at                                          or if to the Company, to
Bioheart, Inc., 13794 NW Fourth Street, Suite 212, Sunrise, FL 33325, Attn: President, or at such
other address of which the Company or the Holder has been advised by notice hereunder.

5

 

     11. Applicable Law. The Warrant is issued under and shall for all purposes be
governed by and construed in accordance with the laws of the State of Florida.

     12. Entire Agreement. This Warrant represents the sole and entire agreement of the
parties with respect to the subject matter hereof, supercedes and replaces any other
representation, promise, assurance, agreement or arrangement between the parties with respect to
such subject matter, and may not be modified, revised or amended without the written consent of the
party to be charged with such modification.

* * * * * *

(signatures on following page)

6

 

     IN WITNESS WHEREOF, the parties have each caused this Warrant to be signed on its behalf, in
its corporate name, by its duly authorized officer, all as of the day and year first above written.

	 	 	 	 	 
	 	Company:

Bioheart Inc.

 	 
	 	By:  	/s/
 	 
	 	 	Name:  	Howard J. Leonhardt 	 
	 	 	Title:  	Chairman & CEO 	 
	 
	 	Holder:

 	 
	 	/s/
 	 
	 	Scott Bromley 	 
	 	 	 

7

 

	 	 	 	 	 

WARRANT EXERCISE FORM

     The undersigned, the Holder of the within Warrant, by and between the undersigned and
Bioheart, Inc., a Florida corporation (the “Company”), dated as of                               , hereby
irrevocably elects to exercise the within Warrant to purchase
                               shares (the
“Warrant Shares”) of the Common Stock of the Company, subject thereto, and hereby makes
payment of $                     per share in payment therefor. The undersigned’s execution of this form
constitutes the undersigned’s agreement to all the terms of the Warrant and to comply therewith.

     The undersigned hereby represents and agrees that the Warrant Shares purchased pursuant hereto
are being purchased for investment and not with a view to the distribution or resale thereof, and
that the undersigned understands that said Warrant Shares have not been registered under the
Securities Laws. The Warrant Shares will bear the appropriate legend to reflect the foregoing.

     Payment of the full purchase price of the Warrant Shares is enclosed herewith, either in cash
or in the form of an official bank check made payable to the Company.

     (Please date, sign and print name, address and federal I.D. or social security number)

			
	     Dated:	 	

 

			
	     Signature of Holder:	 	

 

			
	     Print Name of Holder:	 	

 

			
	     Address:	 	

 

 

			
	      Federal I.D. or Social Security Number:	 	

 

      Signed in the presence of:

 

Print Witness Name:

 

8

 

INVESTMENT REPRESENTATIONS

     The Holder hereby makes the following investment representations, warranties and covenants,
each of which shall be deemed material (and the Company, in executing, delivering and consummating
this Warrant, has relied and will rely upon the correctness and completeness of each of such
representations, warranties and covenants, notwithstanding independent investigation, if any):

          (a) The Warrant and Warrant Stock acquired by the Holder hereunder are being acquired by the
Holder for investment purposes and not with a view to any distribution or resale thereof in any
transaction which would be in violation of the Securities Act of 1933, as amended (including the
rules and regulations promulgated thereunder, the “1933 Act”), or any applicable state
securities laws (the “Securities Laws”). The Holder recognizes that investment in the
Warrant and Warrant Stock involves substantial risks, including but not limited to, the risk of
loss of the entire amount of such investment. The Holder hereby represents that it can bear the
economic risk of losing its entire investment in the Warrant and Warrant Stock and is able to
afford the complete loss of such investment. The Holder has such knowledge and experience in
financial, business and investment matters so as to be capable of evaluating the merits and risks
of an investment in the Warrant and Warrant Stock. The Holder acknowledges that it (and the
Holder’s attorney, accountant or other advisor, if any) has been afforded the opportunity (i) to
ask such questions as it has deemed necessary or appropriate of, and to receive answers from, the
Company concerning the merits and risks of investing in the Warrant and Warrant Stock and (ii) to
request and obtain/inspect such additional information, including, but not limited to, copies of
any documents, records and books pertaining to this investment which the Holder has desired to
obtain and/or inspect, including without limitation the Company’s Private Placement Memorandum
dated January 18, 1999, as amended and supplemented to date. The Holder acknowledges that the
Company has answered all questions and responded to all inquiries and requests for information to
the Holder’s satisfaction. The Holder acknowledges that it has made, independently and without
reliance upon the Company (other than the representations, warranties and agreements of the Company
set forth in this Warrant) or any agent or representative of the Company and based on its own
independent analysis of the Company and such other documents and information as it has deemed
appropriate, its own investment analysis and its own business decision to enter into and consummate
this Warrant and the transactions contemplated hereby. The Holder further acknowledges that it is
not relying on any statements or representations of the Company or any of the Company’s agents for
legal advice with respect to its investment in the Warrant and Warrant Stock.

          (b) The Holder represents that it has no contract, undertaking, agreement or arrangement with
any person to sell, transfer, encumber or pledge to such person or anyone else the Warrant and
Warrant Stock or any part thereof; (b) has adequate means of providing for its current needs and
possible contingencies; and (c) has no need for liquidity of its investment in the Warrant and
Warrant Stock.

9

 

          (c) The Holder acknowledges that the Company is issuing the Warrant and Warrant Stock in
reliance upon an exemption from registration provided in the 1933 Act and the Securities Laws, and
is relying upon these representations, and acknowledge and agrees that the Warrant and Warrant
Stock can only be sold, conveyed or transferred if either registered under the Securities Act and
applicable Securities Laws or pursuant to an available exemption from all applicable registration
requirements and subject to compliance with any other applicable transfer restrictions.

          (e) The Holder acknowledges and understands (i) that there is no public or other market for
the Warrant or Warrant Stock and no such public or other market may ever develop, (ii) there can
be no assurance that the Holder will be able to sell or dispose of the Warrant Stock, and (iii)
that the Company makes no representations or warranties regarding the Company’s possible future
private or public offering of the Warrant Stock, the Company’s fulfillment in the future of any
reporting requirements, under the Exchange Act or otherwise, or regarding the Company’s possible
dissemination of any current or projected financial or other information concerning the Company
(except as specifically required by applicable law).

          (f) The representations, warranties, covenants and agreements of the Holder contained herein
or in any other writing delivered in connection with the transactions contemplated hereby shall be
true and correct in all respects on and as of the date of this Warrant and shall survive the
execution and delivery of this Warrant and the purchase of the Warrant and Warrant Stock.
Moreover, the Holder understands that the Warrant and Warrant Stock are being offered and sold to
it in reliance on specific exemptions from the registration requirements of the 1933 Act and the
Securities Laws and that the Company is relying upon the truth and accuracy of, and the Holder’s
compliance with, the representations, warranties, covenants, agreements, acknowledgments and
understandings set forth in this Warrant in order to determine the availability of such exemptions
and the Holder’s eligibility to acquire the Warrant and Warrant Stock.

          (g) If the Holder is a partnership, corporation, trust or estate, then, the Holder represents
and warrants that: (i) such partnership, corporation, trust or estate has full legal right and
power and all authority and approval required (1) to execute and deliver, or authorize execution
and delivery of, this Warrant and all other instruments executed and delivered by or on behalf of
such partnership, corporation, trust or estate in connection with the purchase of its Warrant and
Warrant Stock; (2) to delegate authority pursuant to a power of attorney and (3) to purchase and
hold such Warrant and Warrant Stock; (ii) the signature of the party signing on behalf of such
partnership, corporation, trust or estate is binding upon such partnership, corporation, trust or
estate; and (iii) such partnership, corporation or trust has not been formed for the specific
purpose of acquiring such Warrant and Warrant Stock, unless each beneficial owner of such entity is
qualified as an “accredited investor” within the meaning of Rule 501(a) of Regulation D under the
Securities Act and has submitted information substantiating such individual qualification.

          (h) The Holder hereby represents and warrants that it is an “accredited investor” as defined
in Rule 501, promulgated by the Securities and Exchange Commission (the
“Commission”) under the 1933 Act. The Holder understands that, (i) the offering and sale of
the Warrant and Warrant Stock have not been and will not be registered under the 1933 Act, and have
not been and will not be registered or qualified under any state securities laws, and (ii) as such,
the Warrant and Warrant Stock constitute “restricted securities” as defined in Rule 144 under the
1933 Act. The Holder further recognizes that the Company is not assuming any obligation to register
the Warrant Stock.

10EX-10.9 Conditionally Exclusive License Agreement

 

EXHIBIT 10.9

February 7, 2000

Dr. Peter Law

Cell Transplants International, LLC

2015 Miller Farms Road

Germantown, TN 38138

REF: License Agreement

Dear Dr. Law,

This letter serves as a full license agreement covering all patents and patents pending and
also future developments related to heart muscle function improvement and angiogenesis. Please
sign and return this today by fax so we may proceed to send you the initial license fee payment of
$500,000, as discussed.

	1.	 	We seek to license all patents related to myogenic cell transplantation and
controlled cell fusion as may be necessary to develop a commercially viable product
within the field of “heart muscle repair and angiogenesis”.
	 
	2.	 	CTI/CTAL will grant Bioheart, Inc. a NON-EXCLUSIVE license for all patents
related to heart muscle regeneration and angiogenesis for the life of the patents.
Sublicensing of these patents by Bioheart, Inc. is not allowed.
	 
	3.	 	Bioheart agrees to provide $500,000 in research funding to CTI/CTAL within 90
days of the signing of this letter of intent to further research mutual interest.
	 
	4.	 	Bioheart will provide immediately to CTI/CTAL or Dr. Peter Law 600,000 shares
of Bioheart common stock at $1.80 per share as part of the license fee payment.
	 
	5.	 	Bioheart will provide CTI/CTAL or Dr. Peter Law, in 30 days, option to acquire
another 600,000 shares of Bioheart common stock at $1.80 per share.
	 
	6.	 	Bioheart, Inc. will pay a royalty of 5% of gross sales of products and services
that directly read upon the claims of the patents.
	 
	7.	 	Bioheart, Inc. will provide agreement which states that dilution of shares of
CTI/CTAL or Dr. Peter Law will at all times be equal to dilution of Mr. Howard
Leonhardt and the family and friends of Mr. Leonhardt.
	 
	8.	 	Dr. Peter Law will be elected to the Board of Directors of Bioheart, Inc.

 

 

	9.	 	CTI/CTAL will be responsible for pursuing and suing infringers of Dr. Law’s
patents and will thus be entitled to 100% of any damages paid in.
	 
	10.	 	Bioheart agrees to enter into a supply agreement with CTI/CTAL for cultured
myoblasts in 30 days.
	 
	11.	 	Bioheart, Inc. will pay $3,000,000 to CTI/CTAL upon INITIATION of a human
clinical trial study of Dr. Law’s patented technology with F.D.A. approval in the
United States (does not include isolated compassionate use or emergency last resort
cases which are not part of the study).
	 
	12.	 	Bioheart, Inc. will pay $5,000,000 to CTI/CTAL upon F.D.A. APPROVAL of method
of heart muscle regeneration utilizing the patented technology.
	 
	13.	 	Right of first refusal — If Dr. Law/CTAL receives a bona fide offer from a
direct competitor of Bioheart’s in heart muscle repair, Bioheart shall have 30 days to
meet this offer to bar competition from obtaining license. Bioheart will have
permission to express this covenant of the agreement to investors as a “semi-exclusive
license”.

Kindest Regards,

	 	 	 
	Howard J. Leonhardt
	 	 
	 

	 	 
	Chairman & CEO

	 	Dr. Peter Law, Chairman & CEO
	 

	 	Cell Transplants International, LLC

2

 

Dr. Peter Law

Cell Transplants International, LLC

2015 Miller Farms Road

Germantown, TN 38138

REF: License Agreement

Dear Dr. Law:

This letter (“Addendum”) amends and supplements that certain full license agreement (“Agreement”)
covering all patents and patents pending and future developments related to heart muscle function
regeneration and Angiogenesis dated February 7, 2000 between Bioheart, Inc. (“Bioheart” or the
“Company”), Dr. Peter Law and Cell Transplants International, LLC (“CTI”). Except as noted below,
the provisions of the Agreement remain in full force and effect. This Addendum shall be deemed
effective as of February 7, 2000.

	1.	 	Dr. Law and CTI shall each execute and deliver to Bioheart the following
agreements concurrently with their execution and delivery of this letter agreement:

	 	(a)	 	a Scientific Advisory Board Consultation Agreement in the form
attached hereto as Exhibit A;
	 
	 	(b)	 	a Supply Agreement in the form attached hereto as Exhibit B;
	 
	 	(c)	 	an Inventions and Proprietary Rights Assignment and
Confidentiality Agreement in the form attached hereto as Exhibit D; and
	 
	 	(d)	 	a Warrant Certificate in the form attached hereto as Exhibit E
(the “Warrant”).

It shall be an express condition precedent to the effectiveness of this Addendum
that each of the above-identified agreements be executed and delivered by the
parties hereto. This Section 1 supersedes Section 10 of the Agreement.

	2.	 	In consideration of Dr. Law’s and CTI’s execution, delivery and performance of
the above-identified agreements as well as the Agreement, as amended and supplemented
hereby, Bioheart, Dr. Law and CTI agree as follows:

	 	(a)	 	the aggregate license/research and development fees payable by
Bioheart under this first paragraph and Section 3 of the Agreement is a total
sum of

 

 

	 	 	 	$1,000,000, of which Dr. Law and CTI acknowledge that $500,000 of this fee
has been paid previously by Bioheart as noted in the first paragraph of the
Agreement. The $500,000 balance of said fees shall be paid upon execution
of this contract. In addition to the obligations under Section 9 of the
Agreement, Dr. Law and CTI shall undertake reasonably diligent and prompt
efforts to enforce said patents by instituting litigation against all third
parties, whether now known or identified in the future with respect to whom
Dr. Law and/or CTI have a reasonable basis for claiming infringement.
Additionally, Dr. Law and/or CTI will continue to provide Bioheart with all
pertinent and critical information in order to file an IND with the FDA and
to have it approved by the FDA. Dr. Law and/or CTI will agree to allow
Bioheart Quality Assurance expert complete access to the CTI facilities in
order for them to (i) assist CTI in compiling adequate QC documentation and
(ii) ensure that CTI will be able to provide Bioheart with FDA QC validated
cells. Additionally, Dr. Law and/or CTI will agree to provide a license, in
reasonable form, to Duke University to continue Bioheart research. This
Section 2(a) supercedes Section 3 of the Agreement in its entirety; and
	 
	 	(b)	 	Bioheart will issue to CTI a 5-year warrant exercisable for
1,200,000 shares of Bioheart common stock at an exercise price of $8.00 per
share, pursuant to the terms of the Warrant, instead of the 600,000 shares and
600,000 options referenced in Sections 4 and 5 of the Agreement. This Section
2(b) supersedes Sections 4 and 5 of the Agreement in their entirety; and
	 
	 	(c)	 	Bioheart will pay $3,000,000 to CTI upon commencement of a bona
fide Phase II human clinical trial study that utilizes technology claimed under
U.S. Patent No. 5,130,141 with F.D.A. approval in the United States (it being
understood that such a study does not include isolated compassionate use or
emergency last resort cases which are not part of study). This Section 2(c)
supersedes Section 11 of the Agreement.

	3.	 	Additionally, if Dr. Law or CTI desires to license or otherwise convey any
rights in and to any of their technology, inventions or patent rights to a third party
in the field of heart muscle regeneration or Angionesis efforts (whether in response to
a bona fide other from such third party or otherwise), Bioheart shall have a right of
first refusal over any such third party to obtain either exclusive or non-exclusive
license and acquire such rights Dr. Law and CTI shall provide written notice to
Bioheart regarding such proposed transaction, terms and, if such proposed transaction
is in response to a bona fide third party offer, the terms of such offer. Bioheart
shall have the first right to complete the proposed transaction with Dr. Law and/or CTI
on the proposed terms by providing written notice to Dr. Law and/or CTI, as the case
may be, of its acceptance of such proposed terms, which

2

 

	 	 	notice shall be provided no later than thirty (30) days after Bioheart’s receipt of
notice regarding such proposed transaction. Bioheart’s failure to provide such
acceptance notice to Dr. Law and/or CTI, as the case may be, within such thirty (30)
day period shall be deemed to constitute rejection of such offer, in which event Dr.
Law and/or CTI shall be entitled to proceed with its/their proposed transaction with
such third party; provided, however, that if the terms of such transaction are
modified or a new offer is made, or if the transaction does not occur within 30
days, the Company shall be entitled to again receive a new notice and a right of
first refusal pursuant to the provisions set forth above with regard to such
modified terms or new offer. It shall be an express condition precedent to
completion of any transaction with a third party that such third party acknowledge
Bioheart’s license rights in and to such technology, and if such transaction
involves the assignment of patent rights by Dr. Law and/or CTI to such third party,
that such third party assume all obligations of Dr. Law and/or CTI as licensor with
respect to Bioheart’s rights in and to the technology being transferred. The
parties hereto acknowledge and agree that Dr. Law and CTI shall not in any event
consider or accept any such third party offers or otherwise enter into or consummate
any such transaction wherein the aggregate consideration payable is less than
$14,000,000. The parties hereto further acknowledge that the value of the
consideration required to be paid by Bioheart, Inc. in connection with an offer to
license any of Dr. Law and/or CTI’s technology, inventions or patent rights to a
third party in the field of heart muscle regeneration and/or Angiogenesis,
exercising its right of first refusal hereunder (whether paid in cash or in the form
of equity securities) shall be equal to the lesser of the bona fide terms offered to
or by such third party or $25,000,000, and in any event Bioheart shall only be
required to pay the cash portion and the common stock traded on an internationally
recognized stock exchange of the consideration that would be paid by such third
party in such proposed transaction. Bioheart will have permission to express this
covenant of the agreement to investors as a “conditionally exclusive license.” This
Section 3 supersedes Section 13 of the Agreement.

[The remainder of this page intentionally left blank; signatures on following page.]

3

 

If the foregoing terms are acceptable to you, please acknowledge your acceptance and agreement by
executing both enclosed originals of this letter agreement and returning one executed original to
my attention.

Kindest Regards,

BIOHEART, INC.

 

John L. Babitt

Chief Financial Officer

Accepted by:

__________________________

Dr. Peter K. Law, Ph.D., individually

CELL TRANSPLANTS INTERNATIONAL LLC

__________________________

By: Dr. Peter K. Law, PhD., Chairman and Executive Officer

4

 

January 18, 2001

VIA FACSIMILE

Mr. John Babitt

Bioheart, Inc.

2400 North Commerce Parkway

Suite 408

Weston, FL 33326

Dear John:

This letter will confirm our previous telephone conversation wherein we discussed Peter Law’s
decision to decline membership on the Board of Directors of Bioheart, Inc. due to potential
conflicts of interest which might arise. You acknowledged the potential conflicts of interest and
agreed that the parties’ relationship more appropriately proceeds without a board position for Dr.
Law. This letter will specifically reference the February 7, 2000 letter agreement between the
parties and confirm that Bioheart, Inc. has satisfied its obligation to offer a board seat to Peter
Law and that Peter Law remains in compliance with that letter agreement despite his declining the
board seat.

If you have any questions in this regard, please feel free to call me. Thanks.

Sincerely,

Anthony C. Pierrangelo

ACP/mbh

cc: Dr. Peter Law

 

 

Exhibit A

BIOHEART, INC.

SCIENTIFIC ADVISORY BOARD

CONSULTATION AGREEMENT

     This SCIENTIFIC ADVISORY BOARD CONSULTATION AGREEMENT (the “Agreement”) is entered into by and
between BIOHEART, INC., a Florida corporation (the “Company” or “Bioheart”) and
PETER LAW (“Consultant”).

A. Consultant will assist the Company in the following matters:

	 	1.	 	Product design evaluation and development strategies.
	 
	 	2.	 	Evaluating instructional and training materials for physicians.
	 
	 	3.	 	Clinical and consultation support to centers utilizing Bioheart products on a
mutually agreed to basis.
	 
	 	4.	 	Clinical trials and design of clinical protocols.
	 
	 	5.	 	Other matters that may come before the Company’s Scientific Advisory Board for
consideration regarding the Company’s products and operations and related matters.

B. Services.

     Consultant will serve as a member of the Company’s Scientific Advisory Board. Consultant
agrees to attend at least one meeting per year in person with company representatives and other
Scientific Advisory Board members to discuss and provide advice related to the Company’s products,
research and development, and operational matters. The Company is required to provide reasonable
advance notice of such meetings. The Consultant shall also be available for consultations by
telephone and to discuss written correspondence from time to time upon request of the Company,
consistent with the schedule and available time of the Consultant. Additionally, Consultant agrees
to license to the Company all patents in the field of use of heart muscle repair and angiogenesis.
Consultant agrees to maintain such patents for their full term. Consultant acknowledges that the
patents/patent applications listed in Schedule I attached hereto have been licensed to the Company
in accordance with the terms of that certain Agreement dated February 7, 2000 by and between the
Company and Consultant as amended.

C. Term.

     The engagement of Consultant hereunder and the term of this Agreement will continue for a
period of three (3) years from the date of execution of this Agreement. Notwithstanding the
foregoing, the Company shall have the right, at its option, to terminate this Agreement immediately
in the event that the Consultant materially breaches the terms of this Agreement,

 

 

which breach is not cured by the Consultant within a reasonable period of time after the
Company has given written notice to the Consultant of such breach.

D. Expenses and Compensation of Consultant.

     The Company will reimburse Consultant for reasonable and documented out-of-pocket expenses
including travel and lodging expenses necessarily incurred in performing services to Company. Such
expenses in excess of $500 shall be pre-approved by the Company.

E. Indemnity.

     The Company shall indemnify and hold the Consultant harmless with respect to any and all
liability and expense caused by the Consultant’s performance of services pursuant to and within the
scope of the engagement provided for in this Agreement, or arising from any claim, suit, demand, or
cause of action against the Company, other than as a result of Consultant’s gross negligence or
willful misconduct, and Consultant shall indemnify and hold Company and its officers and directors
harmless from and against any and all losses, costs, damages, expenses and liability caused by the
gross negligence or willful misconduct of Consultant in performing services hereunder.

F. Confidential and Proprietary Information.

     Pursuant to the terms of this Agreement, Bioheart and Consultants and Scientific Advisory
Board members may exchange certain confidential or proprietary information. In connection with the
exchange of such information, both parties agree that the disclosure of proprietary information
shall be minimized to the extent practical and shall consist only of information necessary for the
purposes contemplated in this Agreement. However, should disclosed documentation inherently or
unavoidably include proprietary information other than the minimum necessary, such information
shall nonetheless be held in confidence and no use made thereof beyond the above-stated purpose.

     The parties shall not disclose such information to others except each party’s employees on a
“need-to-know” basis, and to use such information of the other only for the purposes stated in this
Agreement.

     To the extent that any such information is disclosed, the party disclosing such information
shall identify such information as proprietary or confidential. Any proprietary information, if
orally disclosed, shall be promptly confirmed in writing and identified as proprietary information
if such information is to remain proprietary under this Agreement. All proprietary information and
copies thereof, if any, shall be promptly returned to the party furnishing it when the need for it
no longer exists and, in any event, promptly upon request.

     Neither party shall be liable for disclosure or use of information marked as proprietary which
(1) is now, or which hereafter, through no fault of the receiving party, becomes available to the
public; (2) is already known to the receiving party at the time of disclosure; (3) is hereafter
furnished to others by the owner of the information without restriction disclosure; (4) or is
lawfully obtained by the receiving party from a third party or parties.

2

 

     Each party shall exercise at least the same degree of care of the secrecy and security of
disclosed proprietary information which it receives as it exercises for its own proprietary
information.

     Notwithstanding any other terms of this Agreement to the contrary, this paragraph shall
survive and remain in full force and effect for the term of this Agreement and for a period of two
years thereafter. If the Consultant is a party to any other agreement regarding the subject matter
of this Section F which provides greater rights or benefits to Bioheart with respect to such
subject matter, then the terms of such other agreement shall supercede this Agreement with respect
to, and to the extent they provide greater rights to Bioheart with respect to, such subject matter.

G. Governing Law.

     This agreement will be governed by and construed in accordance with the laws of the State of
Tennessee.

     IN WITNESS WHEREOF, the undersigned have caused this agreement to be executed and delivered as
of the date set forth below.

	 	 	 	 	 
	CONSULTANT 

 	 
	By:  	 	 
	 	 	Peter Law                                   	 
	Date: 	 	 	 
	 

	 	 	 	 	 
	BIOHEART, INC.

 	 
	By:  	 	 
	 	 	John L. Babitt, Chief Financial Officer 	 
	Date: 	 	 	 
	 

3

 

Exhibit B

SUPPLY AGREEMENT

     THIS SUPPLY AGREEMENT (this “Agreement”) is made as of this 1st day of July, 2000 by and
between BIOHEART, INC., a Florida corporation (“Purchaser”), and CELL TRANSPLANTS INTERNATIONAL,
LLC, a Tennessee for profit limited liability corporation (“Supplier”).

RECITALS:

     A. Supplier is a provider of cultured myoblasts.

     B. Purchaser is engaged in research and development efforts relating to heart muscle
regeneration and repair.

     C. Purchaser desires to purchase from Supplier cultured myoblasts (the “Product”) for use by
Purchaser in its research and development efforts and for future treatments and sales

     D. Supplier and Purchaser wish to enter into this Agreement in order to establish terms,
conditions and procedures for the sale by Supplier to Purchaser of the Products.

AGREEMENTS:

     NOW, THEREFORE, for and in consideration of the mutual promises herein contained and other
good and valuable consideration, the receipt and adequacy of which are hereby acknowledged,
Supplier and Purchaser, intending to be legally bound hereby, agree as follows:

     1. Recitals; Exhibits. The foregoing recitals are true and correct and, together with
the attached exhibits, are incorporated herein by this reference.

     2. Agreement to Purchase and Sell; Purchase Orders; Exclusivity.

          (a) Agreement to Purchase and Sell. Supplier shall sell to Purchaser, and Purchaser
shall purchase and accept from Supplier, at the prices and upon the terms and conditions provided
in this Agreement, such amount of the Products as Purchaser may request from time to time.
Supplier agrees to promptly fill all Product orders placed by Purchaser.

          (b) Purchase Orders. All purchase orders submitted by Purchaser and accepted by
Supplier for Products are and shall be subject to this Agreement and shall be deemed to incorporate
the terms and conditions of this Agreement, whether or not so specified in such purchase orders.
Supplier’s acceptances of orders shall be evidenced by Supplier signing and returning the
acknowledgment copy of the order within fifteen (15) days after receipt of the order, together with
a pro-forma invoice for the Products covered by that order. All orders shall contain the
information necessary for Supplier to fulfill the order, which information shall include the
following:

          (i) A reference to this Agreement and Purchaser’s purchase order number;

          (ii) A description and quantity of each of the Products required;

          (iii) The address to which Products are to be directed and the address to which Supplier’s
invoice is to be sent;

          (iv) The requested delivery date; and

          (v) Such other information as Supplier shall reasonably require.

 

 

     The terms and conditions of this Agreement shall take precedence over and govern in the event
of conflict between the terms and conditions of this Agreement the terms and conditions of any
other documents and forms of the parties, including, without limitation, Purchaser’s quotation
request and purchase order forms, Supplier’s quotation form, and any confirmation, acknowledgment
or other similar document. Any provision or data in any order, any subordinate document such as
shipping releases, or any other document originated by either party, or contained in any documents
or forms attached to or referenced in any of the above documents, which modifies, supplements or
conflicts with the terms of this Agreement shall not be binding unless agreed to in writing by the
parties.

          (c) Forecasts. No less often than every calendar quarter during the Term of this
Agreement, Purchaser shall provide to Supplier forecasts of Purchaser’s anticipated Product
requirements. The initial Purchaser forecast is provided in Exhibit A attached to this
Agreement. The next forecast will be due ninety (90) days after the date hereof. Purchaser
acknowledges that purchase orders in excess of the quantities set forth in the most recent forecast
may require additional delivery time as may be mutually acceptable to the parties.

     3. Effective Date and Term. This Agreement shall take effect on the date first set
forth above (the “Effective Date”). Unless sooner terminated in accordance with the terms of this
Agreement, this Agreement shall remain in effect for the period (the “Term”) of five (5) years from
the Effective Date. This Agreement shall be automatically renewed for consecutive additional
one-year periods unless either party provides notice of nonrenewal to the other party not less than
sixty (60) days prior to the end of the then current term.

     4. Purchase Prices. Purchaser shall be charged and agrees to pay the rates set forth
on Exhibit A hereto, for its purchase of the Products. Such rates may be reviewed and
revised as agreed upon between the parties [from time to time/annually/semiannually]. Supplier
shall present any proposed changes to the rates no less than sixty (60) days prior to such rates
becoming effective. If the parties are not able to reach an agreement within thirty (30) days of
the date the proposal is made by Supplier, Supplier shall be able to set such rates as it deems
appropriate, with such rates taking effect thirty (30) days thereafter. The purchase prices shall
be expressed in U.S. Dollars. Supplier agrees to provide products at or below prevailing market
prices by others producing comparable products.

     5. Taxes and Other Charges. In addition to the applicable purchase prices, Supplier
shall separately invoice for, and Purchaser shall pay, all sales, use, excise, value added, gross
receipts, turnover and other taxes and charges imposed by law or required by any government to be
paid or collected by Supplier in connection with the purchase, delivery, sale or use of the Product
pursuant to this Agreement.

     6. Payment Terms. All payments due to Supplier from Purchaser under this Agreement
shall be paid to the Supplier by check or wire transfer. Invoices may be rendered by the Supplier
at any time after the date of Delivery, as defined below. Payment shall be made in U.S. Dollars,
no later than thirty (30) days following the date of Delivery. Each shipment shall constitute an
independent transaction and Purchaser shall pay the invoice for each such transaction strictly in
accordance with these payment terms.

     7. Delivery. Products will be considered delivered by Supplier for purposes of this
Agreement when delivered to Purchaser’s designated carrier FOB. Purchaser shall: (a) contract for
carriage of the Products to the destination and pay the freight, (b) pay any loading costs to the
extent they are not included in the freight, and (c) pay all other costs incurred in connection
with shipment of the Products to the ultimate destination and unloading.

     8. Risk of Loss and Passage of Title. Risk of loss and title shall pass to Purchaser
at the time of Delivery of the Product to Purchaser’s carrier. Title to the Products shall pass to
Purchaser upon receipt of payment of the corresponding invoice by Supplier.

2

 

     9. Representations and Warranties.

     (a) Supplier Representations and Warranties. Supplier represents and warrants to
Purchaser the following:

          (i) Supplier is a corporation duly organized, validly existing and in good standing under the
laws of the State of Tennessee, with full corporate power and authority to execute and deliver this
Agreement and to consummate the transactions contemplated hereby.

          (ii) The execution, delivery and performance of this Agreement and the consummation of the
transactions contemplated hereby by Supplier have been duly and validly authorized and no further
corporate authorization is required on the part of Supplier to consummate the transactions
contemplated hereby.

          (iii) This Agreement and all other documents executed and delivered by Supplier pursuant to
this Agreement constitute the legal, valid and binding obligation of Supplier, enforceable against
Supplier in accordance with their respective terms.

          (iv) The individuals executing this Agreement on behalf of Supplier have been duly authorized
and empowered to execute this Agreement for the purpose of binding Supplier to this Agreement. The
execution, delivery and performance of this Agreement by Supplier does not and will not violate any
contract or other arrangement between Supplier and any third party, or any applicable law or
regulation. No third party consents, governmental approval, filings, registrations or permits are
required in order for Supplier to perform its obligations hereunder.

          (v) The Products provided to Purchaser hereunder do not infringe on any third party’s
intellectual property rights and are free from defects that would eliminate or substantially reduce
their utility in connection with Purchaser’s research and development projects, future treatments
and sales.

          (vi) The Products shall meet and shall be produced and packaged in accordance with all
applicable regulatory requirements and FDA standards at a facility meeting current good
manufacturing practices (“CGMP”) standards. Supplier shall permit U.S. Food and Drug
Administration representatives or other appropriate health authorities to inspect supplier’s
facilities as may be required in order to obtain or maintain permits to sell the Product and CGMP
certifications.

     (b) Purchaser Assurances. Purchaser represents and warrants to Supplier the
following:

          (i) Purchaser is a corporation duly organized, validly existing and in good standing under the
laws of the State of Florida, with full corporate power and authority to execute and deliver this
Agreement and to consummate the transactions contemplated hereby.

          (ii) The execution, delivery and performance of this Agreement and the consummation of the
transactions contemplated hereby by Purchaser has been duly and validly authorized and no further
corporate authorization is required on the part of Purchaser to consummate the transactions
contemplated hereby.

          (iii) This Agreement and all other documents executed and delivered by Purchaser pursuant to
this Agreement constitute the legal, valid and binding obligation of Purchaser, enforceable against
Purchaser in accordance with their respective terms.

          (iv) The individuals executing this Agreement on behalf of Purchaser have been duly
authorized and empowered to execute this Agreement for the purpose of binding Purchaser to this
Agreement, without any third party consents or governmental approvals, filings, registrations or
permits. The execution, delivery and performance of this Agreement by Purchaser does not and will
not violate any contract or other arrangement between Purchaser and any third party, or any
applicable law or regulation.

3

 

     10. Indemnification. Purchaser agrees to indemnify and hold Supplier, its officers,
directors, employees, successors and assigns harmless against all losses, damages and expenses of
whatsoever form or nature, including attorneys’ fees and other costs, whether direct or indirect,
that they, or any of them, may sustain or incur as a result of any acts or omissions of Purchaser,
its customers or any of their directors, officers, employees or agents, including but not limited
to breach of warranty or representation of Purchaser made to Supplier or any third party or failure
of Purchaser to fulfill any covenant or agreement contained herein or made to any third party.
This provision shall survive termination or non-renewal of this Agreement.

     11. Notices. All notices and other communications under this Agreement: (a) shall be
made in writing signed by the authorized agent of the party making the same, (b) shall be delivered
by personal delivery, confirmed telephonic facsimile transmission, or international commercial
express courier, and (c) shall be deemed effective upon receipt. The addresses for all notices and
communications (other than purchase orders and shipping releases) are as follows:

	 	 	 
	If to Supplier:

	 	Cell Transplants International, LLC.
	 

	 	2015 Miller Farms Road
	 

	 	Germantown, TN 38138
	 

	 	Facsimile No.: (901) 751-1808
	 

	 	Attn: Peter Law, Chairman & Chief Executive Officer,

President
	 
	 	 
	If to Purchaser:

	 	Bioheart, Inc.
	 

	 	2400 N. Commerce Parkway
	 

	 	Suite #408
	 

	 	Weston, Florida 33326
	 

	 	Attn: Howard J. Leonhardt, President
	 
	 	 
	With a copy to:

	 	Greenberg Traurig, P.A.
	 

	 	1221 Brickell Avenue
	 

	 	Miami, Florida 33131
	 

	 	Facsimile (305) 961-5812
	 

	 	Attn: Manuel R. Valcarcel

Either party may change the address and facsimile telephone number to which notices and other
communications are to be sent, and may add or delete recipients for notices and other
communications, by sending the other party notice of the changes in accordance with the notice
provisions of this paragraph. In addition, Supplier may change the address for purchase orders and
shipping releases by notifying Purchaser in writing of the changed address in accordance with the
notice provisions of this paragraph.

     12. Assignment. Neither party shall assign or delegate any right, interest or
obligation under this Agreement, except that Supplier may subcontract with third parties for any of
the Product. No assignment, delegation or subcontract by either party shall relieve the assigning,
delegating or subcontracting party from its obligations and liabilities under this Agreement. Any
attempted assignment or delegation in contravention of this prohibition shall be void and shall
constitute a default under this Agreement.

     13. Force Majeure. Each of Supplier and Purchaser shall be excused from its
obligations hereunder, and shall have no liability for any resulting loss or damage, in the event
and to the extent that its performance is delayed or prevented by any event or circumstance
reasonably beyond its control,

4

 

including but not limited to, fire, floods, epidemics, explosion,
embargo, acts or requirements of any government in its sovereign capacity, acts of God, war,
strikes, walkouts, and riots or other civil disturbances, inability to secure raw material or
transportation facilities, or for any act or omission of
carriers or suppliers. Delay in or prevention of performance of either party shall be excused
hereunder only for the period during which such cause continues, and only if the party whose
performance is delayed or prevented gives written notice thereof to the other party within ten (10)
days of the event causing such delay or prevention. The parties hereto shall not have the right to
terminate this Agreement solely as a result of any act or event described in this Paragraph.

     14. Waiver. No course of dealing, course of performance, or failure of either party
strictly to enforce any term, right or condition of this Agreement shall be construed as a waiver
of such term, right, or condition or affect the right to enforce that term, right or condition in
the future, nor shall any express waiver be construed as a continuing waiver of any such term,
right or condition.

     15. Governing Law. The construction, interpretation and performance of this Agreement
shall be governed by the internal laws of the State of Tennessee (without giving effect to their
conflicts of laws provisions).

     16. Entire Agreement. This Agreement constitute the entire agreement between the
parties with respect to its subject matter. All prior or contemporaneous oral and written
agreements, memoranda and representations (and any subsequent purchase order, purchase order
confirmation, or similar document) relating to sales of Product during the term of this Agreement
are superseded by this Agreement.

     17. Amendments. This Agreement may be amended only by a subsequent writing signed by
authorized representatives of both parties hereto, indicating an intent to amend this Agreement.

     18. Severability. If a court of competent jurisdiction adjudges any provision of this
Agreement to be invalid or unenforceable, the remaining provisions shall not be affected thereby,
and the parties shall in good faith attempt to amend this Agreement to eliminate such invalidity or
unenforceability, without thereby affecting the intent of the parties as expressed herein.

     19. Confidentiality. Purchaser and Supplier agree that all confidential commercial,
technical and other information provided hereunder by either party to the other party will be used
only for evaluation purposes or for purposes of performance of this Agreement, shall be kept
confidential by the receiving party using the same standard of care as such receiving party uses to
protect its own similar confidential information, and shall not be sold or disclosed in any manner
to any third party by the receiving party. The obligations under the preceding sentence do not
apply to information which: (a) was previously known to the receiving party free of any obligation
to keep it confidential; or (b) is or becomes publicly available by any means or medium other than
unauthorized disclosure; or (c) is independently developed by the receiving party; or (d) is
disclosed to third parties by the disclosing party without restriction; or (e) is received from a
third party whose disclosure would not violate any confidentiality obligation.

     20. Arbitration.

          (a) Any dispute, controversy or claim arising out of or relating to this Agreement, or the
breach, termination or validity of this Agreement, which has not been resolved by a non-binding
procedure, shall be settled by arbitration in Shelby County, Tennessee (unless the applicable
Supplier and Purchaser agree in writing to another location), in accordance with the Arbitration
Rules of the American Arbitration Association then in effect, except that the Supplier and the
Purchaser agree under any circumstances they shall be permitted reasonable discovery of documents
and depositions of an adequate number of witnesses. Notwithstanding anything to the contrary in
this Agreement, the Supplier and the Purchaser further agree that arbitration shall not be utilized
to determine any dispute, controversy or claim which requires a third party’s presence either as
the correspondent or as an indemnifier, unless the third party agrees to be bound by the
arbitration. Disputes described in the preceding sentence shall be resolved through proceedings
commenced and prosecuted in a state or federal court in Shelby County, Tennessee.

5

 

          (b) Within one week after the Supplier, on the one hand, or the Purchaser, on the other hand,
requests arbitration and the other party receives notice of such request, both parties shall supply
the American Arbitration Association with a list of qualifications for the arbitrators. Within two
weeks after receipt of the parties’ lists of qualifications for the arbitrators, the American
Arbitration Association shall supply the parties with a list of 21 potential arbitrators, and the
Supplier, on the one hand, and the Purchaser, on the other hand, shall each be permitted to strike
up to nine proposed arbitrators and shall notify in writing the American Arbitration Association of
the party’s decisions. Within two weeks after receipt of the parties’ decisions as to the
acceptable potential arbitrators, the American Arbitration Association shall appoint the three
arbitrators from the group of arbitrators which has not been stricken by either party.

          (c) Resolution of disputes, controversies or claims shall be determined by a majority vote of
the arbitration panel. The Supplier, on the one hand, and the Purchaser, on the other hand, shall
share equally the fees, costs and expenses of the arbitration, unless the arbitrators modify the
allocation of such fees, costs and expenses because they have determined that fairness dictates
other than an equal allocation between the parties. Each party shall be responsible for its own
attorneys’ fees, costs of its experts and expenses of its witnesses, unless the arbitrators provide
otherwise because they have determined that fairness so dictates. Any award rendered shall be
final, binding and conclusive (without the right to an appeal, unless such appeal is based on fraud
by the other party in connection with the arbitration process) upon the parties and any judgment on
such award may be enforced in any court having jurisdiction, unless otherwise provided by law. The
party submitting such dispute to arbitration shall inform the American Arbitration Association that
the parties have agreed: (i) to reasonable discovery pursuant to the rules then in effect under the
Federal Rules of Civil Procedure for a period not to exceed 120 days prior to such arbitration and
(ii) to require that the testimony at the arbitration hearing be transcribed.

     21. Termination. In addition to any other right or remedy provided by applicable law
or this Agreement, either party shall have the right to terminate this Agreement if the other
party: (i) becomes insolvent or files a voluntary petition in bankruptcy or for reorganization or
other debtor relief, or a third party petitions to have such party involuntarily declared insolvent
or bankrupt and such petition for involuntary insolvency or bankruptcy is not dismissed within
thirty (30) days after being filed; (ii) makes an assignment for the benefit of creditors, or a
custodian, receiver, intervenor, trustee or similar officer is appointed to take charge of all or
part of its property; (iii) ceases to do business, liquidates or dissolves; or (iv) materially
breaches its obligations under this Agreement and such breach is not cured within thirty (30) days
after notice of breach is received from the non-breaching party; provided, however, upon the
occurrence of a payment default with respect to any shipment of Products hereunder, Supplier shall
also be entitled to cease shipment of any additional Products until such default is remedied.
Termination of this Agreement will not relieve either party from due performance of all obligations
which matured prior to the effective date of such termination, including without limitation
Purchaser’ payment obligations with regard to Products ordered by Purchaser prior to such
termination.

     22. Counterparts. This Agreement may be executed by each party upon a separate
counterpart, each of which shall be deemed an original and all of which together shall constitute
one agreement. Facsimile signature pages shall be acceptable as originals.

[Signatures appear on the next page.]

6

 

     IN WITNESS WHEREOF, the parties have caused this Agreement to be signed by their duly
authorized representatives as of the day and year first written above.

	 	 	 	 	 
	 	SUPPLIER:

CELL TRANSPLANTS INTERNATIONAL, LLC

 	 
	 	By:  	 	 
	 	 	Name:  	Dr. Peter K. Law, Ph.D. 	 
	 	 	Title:  	Chairman & Chief Executive Officer,
President 	 
	 

	 	 	 	 	 
	 	PURCHASER:

BIOHEART, INC., a Florida corporation

 	 
	 	By:  	 	 
	 	 	 	 
	 	 	Title:  	Name: John L. Babitt
Chief Financial Officer 	 

7

 

	 	 	 	 	 

Exhibit A

Cell Transplant International LLC, a Tennessee limited liability corporation (Supplier) will
provide cultured myoblasts to Bioheart, Inc. a Florida corporation (Purchaser) beginning on the
first day of July, 2000. Purchaser agrees to pay Supplier twenty five USD ($25) for every million
(106) of myoblasts. Other terms of the transactions are set forth in the Supply
Agreement

8

 

Exhibit D

BIOHEART, INC.

INVENTIONS AND PROPRIETARY RIGHTS

ASSIGNMENT AND CONFIDENTIALITY AGREEMENT

     This INVENTIONS AND PROPRIETARY RIGHTS ASSIGNMENT AND CONFIDENTIALITY AGREEMENT (the
“Agreement”) sets forth in writing certain agreements, understandings and procedures which shall be
in effect during and after the time that I, the undersigned, am a licensor to BIOHEART, INC. (the
“Company”). This Agreement is entered into in connection with the commencement of my licensing to
the Company (the “Services” consisting of my inventions and proprietary rights on heart muscle
regeneration and angiogenesis). I acknowledge and agree that:

	 	1.	 	No Conflict. During the period of my licensing to the Company, I will
devote my best efforts to the interest of the Company.
	 
	 	2.	 	Proprietary Information. My licensing to the Company creates a
relationship of confidence and trust between the Company and me with respect to any
information:

	 	(a)	 	applicable to the business of the Company and its
subsidiaries and affiliates; or
	 
	 	(b)	 	applicable to the business of any client or customer of the
Company, which may be made known to me by the Company or by any client or
customer of the Company, or learned by me in such context during the period
of license.

	 	 	 	All such current or future information has commercial value in the business in which
the Company is engaged and is hereinafter called “Proprietary Information.” By
way of illustration, but not limitation, Proprietary Information includes
trade secrets, technology, research, designs, drawings. schematics, products,
potential products, programming tools, partnerships, methods of distribution,
services, inventions, marketing plans, strategies, forecasts, plans, budgets,
financial information and customer lists.
	 
	 	3.	 	Nondisclosure of Proprietary Information. At all times during my
license to with the Company and after its termination, I will keep in confidence and
trust all Proprietary Information, and I will not use or disclose any Proprietary
Information or anything directly relating to it without the written consent of the
Company, except as may be necessary in the ordinary course of performing my duties as
an licensor or consultant of the Company. Notwithstanding the foregoing, it is
understood that, at all such times, I am free to use information which is generally
known in the trade or industry not as a result of a breach of
this Agreement to whatever extent and in whatever way I wish. I recognize that

1

 

	 	 	 	the Company has received and in the future will receive from third parties (e.g.,
customers, distributors and the like) their confidential and proprietary
information subject to a duty on the Company’s part to maintain the
confidentiality of such information and to use it only for certain limited
purposes. I agree that I owe the Company and such third parties, during the term
of my license, a duty to hold all such confidential or Proprietary Information in
the strictest confidence and not to disclose it to any person or entity
(except as necessary in carrying out my work for the Company) or to use it for the
benefit of anyone other than for the Company or such third party (consistent with
the Company’s agreement with such third party) without the express written consent
of the Company.

	 	4.	 	Return of Materials. Upon termination of my license to the Company, at
the request of the Company before termination, I will deliver to the Company all
written and tangible material in my possession incorporating the Proprietary
Information.
	 
	 	5.	 	Inventions. As used in this Agreement, the term “Inventions” means
all “Software Inventions” and “Hardware Inventions. Related to heart muscle
regeneration and angiogenesis.” As used in this Agreement, the term “Hardware
Inventions” means any new or useful improvement, idea or invention whether or not
patentable, and all related concepts, designs, maskworks, trademarks, formulae,
processes, manufacturing techniques, trade secrets, artwork or other copyrightable or
patentable works, including all right to obtain, register, perfect and enforce these
proprietary interests. As used in this Agreement, the term “Software Inventions” means
any new or useful improvement, idea, invention whether or not patentable, and all
related concepts, designs, programming tools, manufacturing techniques, trade secrets
or other copyrightable or patentable works, including all rights to obtain, register,
perfect and enforce these proprietary interests. I hereby agree promptly to disclose
and describe to the Company, and I hereby license and agree to license to the Company
or its designee, my patent rights, to all Inventions on heart muscle regeneration and
angiogenesis which I may solely or jointly conceive, develop or reduce to practice
during the period of my license to the Company and for one (1) year thereafter (a)
which relate at the time of conception or reduction to practice of the invention to the
Company’s business or actual or demonstrably anticipated research or development, or
(b) which were developed on any amount of the Company’s time or with the use of any of
the Company’s equipment, supplies, facilities or trade secret information, or (c) which
resulted from any work I performed for the Company.
	 
	 	6.	 	Injunctive Relief; Attorneys’ Fees. A breach of any of the promises or
agreements contained herein will result in irreparable and continuing damage to

2

 

	 	 	 	the Company for which there will be no adequate remedy at law, and the Company
shall be entitled to injunctive relief and/or a decree for specific performance,
and such other relief as may be proper (including monetary damages if
appropriate), all of which remedies shall be available without requiring the
Company to post a bond or any other similar requirement, which are hereby waived
by me. In the event of any action at law or in equity to enforce or interpret any
provision of this Agreement, te prevailing party in any such action shall be
entitled to recover from the other party all of its costs incurred in connection
with such action, including, but not limited to, its reasonable attorneys’ fees.

7. Miscellaneous

	 	(a)	 	The waiver by the Company of a breach of any provision of this
Agreement by me shall not operate or be construed as a waiver of any other or
subsequent breach by me.
	 
	 	(b)	 	If any provision of this Agreement is held to be invalid, void
or unenforceable, the remaining provisions shall nevertheless continue in full
force and effect without being impaired or invalidated in any way.
	 
	 	(c)	 	This Agreement shall be construed in accordance with, and
governed by, the laws of the State of Florida, applicable to contracts executed
and performed in Florida by Florida residents.
	 
	 	(d)	 	The term “Company” includes the Company and its affiliates and
subsidiaries.
	 
	 	(e)	 	This Agreement represents my entire understanding with the
Company with respect to the subject matter of this Agreement and supersedes all
previous understandings written or oral other than any other agreements that
are written and signed by me and the Company. This Agreement may be amended or
modified only with the written consent of both me and the Company. No oral
waiver, amendment or modification shall be effective under any circumstances
whatsoever.
	 
	 	(f)	 	I certify and acknowledge that I have carefully read all of the
provisions of this Agreement and that I understand and will fully and
faithfully comply with such provisions.

3

 

	 	 	 	 	 
	COMPANY 	BIOHEART, INC., a Florida corporation

 	 
	 	By:  	 	 
	 	Title:  	 
	 	Dated: 	 
	 

	 	 	 	 	 
	Licensor 	 	 
	 	 	 	 	 
	 	Printed Name:   	Peter K. Law, Ph.D.
 	 
	 	Dated: 	 	 
	 	 	 	 
	 

4

 

Exhibit E

THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS (THE
“SECURITIES LAWS”), AND MAY NOT BE OFFERED FOR SALE, SOLD, ASSIGNED, TRANSFERRED OR OTHERWISE
DISPOSED OF, UNLESS REGISTERED PURSUANT TO THE PROVISIONS OF THE SECURITIES LAWS OR AN OPITION OF
COUNSEL SATISFACTORY TO THE COMPANY IS OBTAINED TO THE EFFECT THAT SUCH DISPOSITION IS IN
COMPLIANCE WITH AN AVAILABLE EXEMPTION FROM SUCH REGISTRATION, AND ONLY IF OTHERWISE PERMITTED
UNDER THE TERMS OF THIS WARRANT.

Bioheart, Inc.

(a Florida corporation)

As of February 7, 2000

Warrant Certificate for the Purchase of Shares of Common Stock

Not Transferable or Exercisable

Except as Specified Herein

Void After Expiration Date

     THIS CERTIFIES, that, for value received from Cell Transplants International, LLC (the
“Holder”), Bioheart, Inc., a Florida corporation (the “Company”) hereby grants to Holder,
subject to the terms, provisions and conditions of this Warrant, the right to purchase from the
Company up to One Million Two Hundred Thousand (1,200,000) fully paid and non-assessable shares of
Common Stock (as defined hereinbelow), of the Company, at a price of Eight Dollars ($8.00) per
share (the “Exercise Price”), payable in cash; provided, however, that the
number of shares of Common Stock purchasable pursuant to this Warrant and the Exercise Price are
subject to adjustment pursuant to the terms hereof. This Warrant is issued pursuant to that certain
“full license agreement” dated February 7, 2000, as amended, among the Company, Holder and Dr.
Peter Law, and constitutes the “warrant” required to be given thereunder.

     The term “Common Stock” as used herein shall mean the Common Stock, par value $.001 per share,
of the Company as constituted on February 7, 2000 (the “Base Date”). The number of shares of Common
Stock to be received upon the exercise of this Warrant may be adjusted from time to time as
hereinafter set forth. The shares of Common Stock deliverable upon the exercise of this Warrant,
and as adjusted from time to time, are hereinafter referred to as “Warrant Stock.” The term “Other
Securities” as used herein shall mean any other equity or debt securities that may be issued by the
Company in addition to or in substitution for the Warrant Stock as provided herein.

 

 

     The Holder agrees with the Company that this Warrant is issued, and all the rights hereunder
shall be, subject to, the conditions, limitations and provisions set forth herein.

     1. Exercise of Warrant.

          1.1. Exercise Period. This Warrant may be exercised in whole or in part, at any time,
or from time to time ( but in no event shall this Warrant be exercised more than 10 times) pursuant
to the procedures and subject to the terms, conditions and limitations provided herein, during the
period from the Base Date until February 6, 2005 (the “Expiration Date”), but in no event shall the
total aggregate number of shares of Common Stock purchased hereunder exceed 1,200,000 (subject to
adjustment as provided herein). From and after the Expiration Date, this warrant shall be void and
the Holder shall have no rights hereunder.

          1.2. Manner of Exercise. This Warrant may be exercised, in whole or in part, at any
time on or before the Expiration Date (but in no event more than ten times during such period), in
increments of not less than 10,000 shares of Warrant Stock per exercise, and solely in accordance
with the procedures, terms, conditions and limitations provided herein. To exercise this Warrant,
the Holder shall present and surrender this Warrant to the Company at its principal executive
office, with the Warrant Exercise Form attached hereto duly executed by the Holder and accompanied
by payment (in the form of either cash or by official bank check, made payable to the order of the
Company), of the aggregate Exercise Price for the total aggregate number of shares specified in
such form, duly executed by the Holder and in form satisfactory to the Company, for which this
Warrant is exercised. If this Warrant should be exercised in part only (and this Warrant has not
been exercised ten times or otherwise terminated), the Company shall upon surrender of this Warrant
for cancellation in connection with such exercise, execute and deliver a new Warrant of like form,
tenor and terms evidencing the rights of the Holder thereof to purchase the balance of the shares
of Warrant Stock purchasable hereunder. Upon receipt by the Company of this Warrant, together with
duly executed Warrant Exercise Form and payment of the Exercise Price for the shares to be
acquired, in proper form for exercise, and subject to the Holder’s compliance with all requirements
of this Warrant for the exercise hereof, the Holder shall be deemed to be the holder of record of
the shares of Common Stock (or Other Securities) issuable upon such exercise, notwithstanding that
the stock transfer books of the Company shall then be closed or that certificates representing such
shares of Common Stock shall not then be actually delivered to the Holder; provided,
however, that no exercise of this Warrant shall be effective, and the Company shall have no
obligation to issue any Common Stock or Other Securities to the Holder upon any attempted exercise
of this Warrant, unless (A) the Holder shall have first delivered to the Company appropriate
investment representations, in form and substance reasonably satisfactory to the Company, such as
those delineated in Exhibit A hereto, so as to provide the Company with proper assurances that the
securities issuable upon exercise hereof may be issued without violation of the registration
requirements of the Securities Act of 1933, as amended (including the rules and regulations
promulgated thereunder, the “Securities Act”) and all applicable state securities or “blue
sky” laws (the “Securities Laws); including without limitation representations that the exercising
Holder is an “accredited investor” as defined in Regulation D under the Securities Act and that the
Holder is familiar with the Company and its business and financial condition and has had an
opportunity to ask questions and receive documents relating thereto to Holder’s reasonable
satisfaction (and by the Holder’s

-2-

 

execution and delivery of this Warrant the Holder hereby makes such representations (including
those on Exhibit “A” hereto) to the Company in connection with the Holder’s acquisition of this
Warrant) and (B) if requested by the Company and if the Company’s Common Stock is not then publicly
traded on any recognized securities exchange or over-the-counter market, the Holder shall execute
and deliver to the Company a shareholders agreement (in the capacity as a shareholder thereunder)
in such form as other shareholders who purchased shares of the Company in its private offering may
then be subject (the “Shareholders Agreement”).

     2. Reservation of Shares. The Company will at all times reserve for issuance and
delivery upon exercise of this Warrant a proper and sufficient number of shares of Common Stock (or
Other Securities) from time to time receivable by the Holder upon exercise of this Warrant. All
such shares (and Other Securities) shall be duly authorized and, when issued and delivered upon
such exercise in accordance with the terms and provisions hereof, shall be validly issued, fully
paid and non-assessable shares (or Other Securities) of the Corporation.

     3. Fractional Shares. Notwithstanding anything to the contrary herein, the Company
shall not be required to issue certificates representing fractions of shares of Common Stock (or
Other Securities) upon the exercise of this Warrant, nor shall it be required to issue scrip or pay
cash in lieu of fractional interests, it being the intent of the parties that all fractional
interests shall be eliminated by requiring the Holder to make the appropriate payment to purchase
whole shares of Common Stock (or Other Securities).

     4. Assignment or Loss of Warrant. Subject to the transfer restrictions herein
(including Sections 7, 8 and 9, and the notice paragraph at the top of the first page of this
Warrant which is incorporated herein), upon surrender of this Warrant to the Company or at the
office of its stock transfer agent, if any, with the Assignment Form annexed hereto duly executed
and funds sufficient to pay any transfer tax (and any required legal opinion), the Company shall,
without charge, execute and deliver a new Warrant of like tenor in the name of the assignee named
in such instrument of assignment and this Warrant shall promptly be canceled. Upon receipt by the
Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of
this Warrant, and of reasonably satisfactory indemnification by the Holder, and reimbursement to
the Company of all reasonable expenses incidental thereto, and upon surrender and cancellation of
this Warrant, if mutilated, the Company shall execute and deliver a replacement Warrant of like
tenor and date, in lieu hereof.

     5. Rights of the Holder. Notwithstanding any term or provision of this Agreement,
prior to and until such time as the Holder has properly exercised this Warrant as provided herein
and thereupon has become the holder of shares of Common Stock (or Other Securities), the Holder
shall not, by virtue of any provision of this Agreement, be entitled to any rights, entitlements or
benefits of a shareholder of the Company, either at law or in equity, including, without
limitation, the rights, entitlements and benefits as a shareholder to (a) vote on or consent with
regard to any proposed action of or regarding the Company, or (b) receive (i) dividends or any
other distributions made to shareholders, (ii) notice of or the right to attend any meeting(s) of
shareholders of the Company, or (iii) notice of any other proceedings of or regarding the Company.
The rights of the Holder are limited to those expressed in this Warrant.

-3-

 

     6. Anti-Dilution Provisions.

          6.1. Adjustment for Stock Splits and Certain Other Transactions. If the Company shall
at any time after the Base Date and prior to the Expiration Date subdivide its outstanding shares
of Common Stock (or Other Securities at the time receivable upon the exercise of the Warrant) by
recapitalization, reclassification or split-up thereof, or if the Company shall distribute shares
of Common Stock to its shareholders, the number of shares of Common Stock (or such Other
Securities) subject to this Warrant immediately prior to such stock dividend or subdivision shall
be appropriately and proportionately increased as provided in this paragraph below, and if the
Company shall at any time after the Base Date and prior to the Expiration Date combine the
outstanding shares of Common Stock by recapitalization, reclassification or combination thereof,
the number of shares of Common Stock subject to this Warrant immediately prior to such combination
shall be appropriately and proportionately decreased as provided in this paragraph below. Any such
adjustment, and any related adjustment to the Exercise Price, pursuant to this Section 6.1 shall be
effective at the close of business on the effective date of such subdivision or combination or if
any adjustment is the result of a stock dividend or distribution then the effective date for such
adjustment based thereon shall be the record date therefor. Whenever the number of shares of Common
Stock purchasable upon the exercise of this Warrant is to be adjusted as provided in this paragraph
above, such adjustment shall be made by multiplying the number of shares then subject to issuance
under this Warrant by a fraction (x) the numerator of which shall be the number of shares of Common
Stock outstanding immediately after the event for which such adjustment is to made, and (y) the
denominator of which shall be the number of shares of Common Stock outstanding immediately prior to
such event.

          Whenever the number of shares of Common Stock purchasable upon the exercise of this Warrant is
adjusted, as provided in this Section 6.1, the Exercise Price shall be adjusted to the nearest cent
by multiplying such Exercise Price immediately prior to such adjustment by a fraction (x) the
numerator of which shall be the number of shares of Common Stock purchasable upon the exercise
immediately prior to such adjustment, and (y) the denominator of which shall be the number of
shares of Common Stock so purchasable immediately thereafter. Any adjustment under Section 6 of
this Warrant determined in good faith by the Company’s board of directors shall be final and
binding upon the Holder.

          6.2. Adjustment for Reorganization, Consolidation, Merger, Etc. In case of any
reorganization or recapitalization of the Company (or any other corporation, the securities of
which are at the time receivable on the exercise of this Warrant) after the Base Date and prior to
the Expiration Date or in case during such period the Company (or any such other corporation) shall
consolidate with or merge into another corporation or convey all or substantially all of its assets
to another corporation, then, and in each such case, the Holder of this Warrant upon the exercise
thereof as provided in Article 1 at any time after the consummation of such reorganization,
consolidation, merger or conveyance, shall be entitled to receive, in lieu of the securities and
property receivable upon the exercise of this Warrant prior to such consummation, the securities or
property to which such Holder would have been entitled upon such consummation if such Holder had
exercised this Warrant immediately prior thereto; in each

-4-

 

such case, the terms of this Warrant shall be applicable to the securities or property
receivable upon the exercise of this Warrant after such consummation.

7. Restrictions on Transfer of Warrant and Warrant Stock; Cancellation and Redemption.

          7.1. Company Consent and Shareholders Agreement. In addition to any other
requirements of this Warrant, (a) neither this Warrant nor any rights or interest of the Holder
hereon, may be sold, assigned, transferred, pledged, hypothecated or otherwise disposed of (in any
such case, “Transferred”) without the prior written consent of the Company, and (b) if the Holder
is then a party (or required under Section 1.3 to be a party) to the Shareholders Agreement,
neither any Warrant Stock nor Other Securities may be Transferred unless permitted under the terms
of the Shareholders Agreement.

          7.2. Transfers to Comply with the Securities Act. This Warrant and any Warrant Stock
or Other Securities purchased hereunder may not be sold, transferred, pledged, hypothecated or
otherwise disposed of except as follows (and subject to other applicable provisions of this
Warrant): (a) to a person who, in the opinion of counsel to the Company, is a person to whom this
Warrant or the Warrant Stock or Other Securities may legally be transferred without registration
and without the delivery of a current prospectus under the Securities Act with respect thereto and
then only against receipt of an agreement of such person to comply with the provisions of this
Section 7 with respect to any resale or other disposition of such securities and containing
appropriate representations to provide the Company with reasonable assurances that the transfer by
the Holder to such person complies with the Securities Act; or (b) to any person upon delivery of a
prospectus then meeting the requirements of the Securities Act (and any applicable state securities
laws) relating to such securities and the offering thereof for such sale or disposition. This
Warrant may only be transferred in full, solely as permitted under this Agreement, and may not be
split up or transferred in part.

          7.3. Cancellation of Warrant and Redemption of Warrant Stock or Other Securities.
Notwithstanding any provision of this Agreement to the contrary, this warrant, or any
unexercised portion hereof, as the case may be, shall be cancelled and shall terminate, and any
Warrant Stock or Other Securities then held by the Holder (or a subsequent transferee) shall be
subject to redemption by the Company at the lower of the Exercise Price paid therefore or the then
current fair market value of said Warrant Stock or Other Securities, immediately upon delivery of
written notice thereof by the Company to the Holder (or such other holder) in the event that the
patents licensed to the Company by the initial Holder or such Holder’s affiliates that read on any
of the products or processes made, used or sold by the Company are adjudged or otherwise determined
to be invalid, adverse to the subject patent as to inventorship, determined not to read upon
products, processes or materials made used or sold by the Company or cancelled in a reexamination
proceeding in the United States Patent and Trademark Office; provided, however, that such
determination is made in the form of a judgment by a court of competent jurisdiction, a decision
from an arbitrator or arbitration panel presiding over an arbitration proceeding involving the
subject patent(s), or the result of a reexamination proceeding in the United States Patent and
Trademark Office involving the subject patent(s), as the case may be, such determination in each
case not being further reviewable due to the

-5-

 

exhaustion of all permissible applications for rehearing or review by a superior tribunal or
through the expiration of time permitted for such applications. For purposes of this agreement
section 7.3 shall only be applicable upon (i) Bioheart’s reexamination of the patent, which will
occur by August 21, 2000 and (ii) a negative outcome from a legal proceeding against a possible
infringer of the licensed patents that Dr. Law and/or CTI have a agreed to pursue. Upon successful
reexamination of the patent by the PTO and a successful legal proceeding that validates the covered
field of use of the patent for heart muscle regeneration section 7.3 of this agreement shall
terminates.

     8. Legend Upon Issued Shares. Unless the shares of Warrant Stock or Other Securities
have been registered under the Securities Act, upon exercise of this Warrant and the issuance of
any of the shares of Warrant Stock, all certificates representing such shares shall bear
substantially the following legend:

     The securities represented by this certificate have not been
registered under the Securities Act of 1933, as amended, and may not
be sold, offered for sale, assigned, transferred or otherwise
disposed of, unless registered pursuant to the provisions of that
Act and applicable state securities laws or unless an opinion of
counsel to the Corporation is obtained stating that such disposition
is in compliance with an available exemption from such registration.

     In addition, all certificates representing the shares of Warrant Stock or
Other Securities shall bear substantially the following legend (and all transferees
thereof shall be bound thereby and by the terms of Section 7.3 hereof), which
legend shall be removed by the Company upon request of the holder thereof (if at
such time there is no outstanding claim under Section 7.3 hereof that has not been
finally resolved and there is no potential claim alleged under Section 7.3 as to
which there is a pending proceeding for determination as provided in Section 7.3)
upon the earlier to occur of (i) the fifth anniversary of the date of this Warrant,
or (ii) as to the applicable shares or Other Securities, when such shares or
securities are sold after February 7, 2003 (a) in a brokered public-market sale in
accordance with Rule 144 under the Securities Act (if such sale is otherwise
permitted under this Warrant, the Shareholders Agreement and the Holders’s other
agreements with the Company), or (b) in a transaction registered under and in
compliance with the requirements of the Securities Act (if such sale is otherwise
permitted under this Warrant, the Shareholders Agreement and the Holder’s
agreements with the Company):

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO MANDATORY
REDEMPTION BY THE ISSUING CORPORATION PURSUANT TO THE TERMS AND CONDITIONS
OF A WARRANT AGREEMENT, DATED AS OF FEBRUARY 7, 2000, WHICH AGREEMENT MAY BE
EXAMINED AT THE OFFICES OF THE COMPANY.

-6-

 

During the time when the foregoing legend is required, no Transfer of any
Warrant Stock or Other Securities subject thereto shall be permitted or
recognized unless and until the transferee agrees with the Company in
writing to be bound by the provisions of Section 7.3 hereof.

     9. Assignment. This Warrant and all of the terms, provisions and conditions hereof
shall be binding upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns, but neither this Warrant nor any of the rights, benefits,
interests or obligations hereunder shall be assigned or delegated by any party hereto without the
prior written consent of the other party.

     10. Notices. All notices required hereunder shall be in writing and shall be deemed
given when telegraphed, delivered personally or three days after mailing when mailed by certified
or registered mail, return receipt requested, to the Company or the Holder, as the case may be, for
whom such notice is intended, if to the Holder, at 2015 Miller Farms Road, Germantown, TN 38138 or
if to the Company, to Bioheart, Inc., 2400 N. Commerce Parkway, Ste. #408, Weston, FL 33326, Attn:
President, or at such other address of which the Company or the Holder has been advised by notice
hereunder.

     11. Applicable Law. The Warrant is issued under and shall for all purposes be
governed by and construed in accordance with the laws of the State of Florida.

     12. Entire Agreement. This Warrant represents the sole and entire agreement of the
parties with respect to the subject matter hereof, supercedes and replaces any other
representation, promise, assurance, agreement or arrangement between the parties with respect to
such subject matter, and may not be modified, revised or amended without the written consent of the
party to be charged with such modification.

*   *   *   *   *   *

(signatures on following page)

-7-

 

     IN WITNESS WHEREOF, the parties have each caused this Warrant to be signed on its behalf, in
its corporate name, by its duly authorized officer, all as of the day and year first above written.

	 	 	 	 	 
	 	Company:

Bioheart Inc.

 	 
	 	By:  	 	 
	 	 	Name:  	John L. Babitt 	 
	 	 	Title:  	Chief Financial Officer 	 
	 

Holder:

	 	 	 	 	 
	 	Cell Transplants International, LLC

 	 
	 	By:  	 	 
	 	 	Name:  	Dr. Peter K. Law, Ph.D. 	 
	 	 	Title:  	Chairman, CEO and President 	 
	 

-8-

 

WARRANT EXERCISE FORM

     The undersigned, the Holder of the within Warrant, by and between the undersigned and
Bioheart, Inc., a Florida corporation (the “Company”), dated as of ___________________________, hereby
irrevocably elects to exercise the within Warrant to purchase ___________________________ shares (the “Warrant
Shares”) of the Common Stock of the Company, subject thereto, and hereby makes payment of
$______________per share in payment therefor. The undersigned’s execution of this form constitutes the
undersigned’s agreement to all the terms of the Warrant and to comply therewith.

     The undersigned hereby represents and agrees that the Warrant Shares purchased pursuant hereto
are being purchased for investment and not with a view to the distribution or resale thereof, and
that the undersigned understands that said Warrant Shares have not been registered under the
Securities Laws. The Warrant Shares will bear the appropriate legend to reflect the foregoing.

     Payment of the full purchase price of the Warrant Shares is enclosed herewith, either in cash
or in the form of an official bank check made payable to the Company.

     (Please date, sign and print name, address and federal I.D. or social security number)

			
	     Dated:	 	
 

			
	     Signature of Holder:	 	
 

			
	     Print Name of Holder:	 	
 

			
	     Address:	 	
 

			
	     Federal I.D. or Social Security Number:	 	
 

     Signed in the presence of:

     _________________________________________________________

     Print Witness Name:

-9-

 

ASSIGNMENT FORM

[To be executed by the registered holder

if such holder desires to transfer

the Warrant Certificate]

			
	     FOR VALUE RECEIVED, the undersigned,	 	
 
(print name of Assignor)

(“Assignor”) hereby sells, assigns and transfers unto

			
	 	 	
 
(print name of Assignee)

all of Assignor’s right, title and interest in, to and under certain Warrant issued by Bioheart,
Inc. (the “Company”) to _______________________, dated
_______________________, and appoints

     _______________________, attorney to transfer such right on the books of the Company. with
full power of substitution in the premises.

DATED: ___________________________

	 	 	 	 	 
	ASSIGNOR:	 	ASSIGNEE: The undersigned agrees with Assignor
and the Company to all of the terms of the
Warrant as a Holder thereunder and to comply
therewith.
	 
	 	 	 	 
	 
	 	 	 	 
	Signature 

Print Name:
	 	 	 	 
	 
	 	 	 	 
	 	 	 
	 

	 	Signature

Print Name:
	 
	 	 	 	 
	 
	 	 	 	 
	Signature, if jointly held 

Print Name:
	 	 	 	 
	 
	 	 	 	 
	 	 	 
	 	 	Signature, if jointly held
	 	 	Print Name:
	 
	 	 	 	 
	 

	 	Address:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

-10-

 

INVESTMENT REPRESENTATIONS

     The Holder hereby makes the following investment representations, warranties and covenants,
each of which shall be deemed material (and the Company, in executing, delivering and consummating
this Warrant, has relied and will rely upon the correctness and completeness of each of such
representations, warranties and covenants, notwithstanding independent investigation, if any):

     (a) The Warrant and Warrant Stock acquired by the Holder hereunder are being acquired by the
Holder for investment purposes and not with a view to any distribution or resale thereof in any
transaction which would be in violation of the Securities Act of 1933, as amended (including the
rules and regulations promulgated thereunder, the “1933 Act”), or any applicable state
securities laws (the “Securities Laws”). The Holder recognizes that investment in the
Warrant and Warrant Stock involves substantial risks, including but not limited to, the risk of
loss of the entire amount of such investment. The Holder hereby represents that it can bear the
economic risk of losing its entire investment in the Warrant and Warrant Stock and is able to
afford the complete loss of such investment. The Holder has such knowledge and experience in
financial, business and investment matters so as to be capable of evaluating the merits and risks
of an investment in the Warrant and Warrant Stock. The Holder acknowledges that it (and the
Holder’s attorney, accountant or other advisor, if any) has been afforded the opportunity (i) to
ask such questions as it has deemed necessary or appropriate of, and to receive answers from, the
Company concerning the merits and risks of investing in the Warrant and Warrant Stock and (ii) to
request and obtain/inspect such additional information, including, but not limited to, copies of
any documents, records and books pertaining to this investment which the Holder has desired to
obtain and/or inspect, including without limitation the Company’s Private Placement Memorandum
dated January 18, 1999, as amended and supplemented to date. The Holder acknowledges that the
Company has answered all questions and responded to all inquiries and requests for information to
the Holder’s satisfaction. The Holder acknowledges that it has made, independently and without
reliance upon the Company (other than the representations, warranties and agreements of the Company
set forth in this Warrant) or any agent or representative of the Company and based on its own
independent analysis of the Company and such other documents and information as it has deemed
appropriate, its own investment analysis and its own business decision to enter into and consummate
this Warrant and the transactions contemplated hereby. The Holder further acknowledges that it is
not relying on any statements or representations of the Company or any of the Company’s agents for
legal advice with respect to its investment in the Warrant and Warrant Stock.

     (b) The Holder represents that it has no contract, undertaking, agreement or arrangement with
any person to sell, transfer, encumber or pledge to such person or anyone else the Warrant and
Warrant Stock or any part thereof; (b) has adequate means of providing for its current needs and
possible contingencies; and (c) has no need for liquidity of its investment in the Warrant and
Warrant Stock.

-11-

 

     (c) The Holder acknowledges that the Company is issuing the Warrant and Warrant Stock in
reliance upon an exemption from registration provided in the 1933 Act and the Securities Laws, and
is relying upon these representations, and acknowledge and agrees that the Warrant and Warrant
Stock can only be sold, conveyed or transferred if either registered under the Securities Act and
applicable Securities Laws or pursuant to an available exemption from all applicable registration
requirements and subject to compliance with any other applicable transfer restrictions.

     (e) The Holder acknowledges and understands (i) that there is no public or other market for
the Warrant or Warrant Stock and no such public or other market may ever develop, (ii) there can
be no assurance that the Holder will be able to sell or dispose of the Warrant Stock, and (iii)
that the Company makes no representations or warranties regarding the Company’s possible future
private or public offering of the Warrant Stock, the Company’s fulfillment in the future of any
reporting requirements, under the Exchange Act or otherwise, or regarding the Company’s possible
dissemination of any current or projected financial or other information concerning the Company
(except as specifically required by applicable law).

     (f) The representations, warranties, covenants and agreements of the Holder contained herein
or in any other writing delivered in connection with the transactions contemplated hereby shall be
true and correct in all respects on and as of the date of this Warrant and shall survive the
execution and delivery of this Warrant and the purchase of the Warrant and Warrant Stock.
Moreover, the Holder understands that the Warrant and Warrant Stock are being offered and sold to
it in reliance on specific exemptions from the registration requirements of the 1933 Act and the
Securities Laws and that the Company is relying upon the truth and accuracy of, and the Holder’s
compliance with, the representations, warranties, covenants, agreements, acknowledgments and
understandings set forth in this Warrant in order to determine the availability of such exemptions
and the Holder’s eligibility to acquire the Warrant and Warrant Stock.

     (g) If the Holder is a partnership, corporation, trust or estate, then, the Holder represents
and warrants that: (i) such partnership, corporation, trust or estate has full legal right and
power and all authority and approval required (1) to execute and deliver, or authorize execution
and delivery of, this Warrant and all other instruments executed and delivered by or on behalf of
such partnership, corporation, trust or estate in connection with the purchase of its Warrant and
Warrant Stock; (2) to delegate authority pursuant to a power of attorney and (3) to purchase and
hold such Warrant and Warrant Stock; (ii) the signature of the party signing on behalf of such
partnership, corporation, trust or estate is binding upon such partnership, corporation, trust or
estate; and (iii) such partnership, corporation or trust has not been formed for the specific
purpose of acquiring such Warrant and Warrant Stock, unless each beneficial owner of such entity is
qualified as an “accredited investor” within the meaning of Rule 501(a) of Regulation D under the
Securities Act and has submitted information substantiating such individual qualification.

     (h) The Holder hereby represents and warrants that it is an “accredited investor” as defined
in Rule 501, promulgated by the Securities and Exchange Commission (the
“Commission”) under the 1933 Act. The Holder understands that, (i) the offering and sale of
the Warrant and Warrant Stock have not been and will not be registered under the 1933 Act, and have
not been and will not be registered or qualified under any state securities laws, and (ii) as such,
the Warrant and Warrant Stock constitute “restricted securities” as defined in Rule 144 under the
1933 Act. The Holder further recognizes that the Company is not assuming any obligation to register
the Warrant Stock.

-12-

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