Document:

EX-10.1

 Exhibit 10.1 
  

 
 ASSET PURCHASE AGREEMENT 

by and between 
 IGNYTA,
INC. 
 and 

CEPHALON, INC. 
 dated
as of March 17, 2015 

 Table of Contents 

 

							
	 		 		Page	 
		
	 ARTICLE 1 Definitions
		 	1	  
			
	 1.1  
		 Defined Terms
		 	1	  
	 1.2  
		 Construction of Certain Terms and Phrases
		 	1	  
		
	 ARTICLE 2 Purchase and Sale of Assets
		 	1	  
			
	 2.1  
		 Purchase and Sale of Assets
		 	1	  
	 2.2  
		 Assignability and Consents
		 	2	  
		
	 ARTICLE 3 Assumption of Assumed Liabilities
		 	2	  
		
	 ARTICLE 4 Purchase Price and Payment
		 	3	  
			
	 4.1  
		 Purchase Price
		 	3	  
	 4.2  
		 Purchase of Compound Inventory and Product Inventory
		 	3	  
	 4.3  
		 Payment of Sales, Use and Other Taxes
		 	3	  
	 4.4  
		 Allocation of Purchase Price; Tax Treatment
		 	3	  
	 4.5  
		 Withholding
		 	4	  
		
	 ARTICLE 5 Closing
		 	4	  
			
	 5.1  
		 Time and Place
		 	4	  
	 5.2  
		 Deliveries at Closing
		 	4	  
		
	 ARTICLE 6 Representations and Warranties of Seller
		 	5	  
			
	 6.1  
		 Organization, Etc.
		 	5	  
	 6.2  
		 Authority; Binding Nature
		 	5	  
	 6.3  
		 Non-Contravention; Consents
		 	6	  
	 6.4  
		 Reserved
		 	6	  
	 6.5  
		 Title to Purchased Assets
		 	6	  
	 6.6  
		 Assumed Contracts
		 	6	  
	 6.7  
		 Intellectual Property Rights
		 	7	  
	 6.8  
		 Litigation
		 	9	  
	 6.9  
		 Permits; Regulatory Compliance
		 	9	  
	 6.10
		 Compound and Product Inventory
		 	10	  
	 6.11
		 Product Data
		 	10	  
	 6.12
		 Brokers
		 	10	  
	 6.13
		 Taxes
		 	11	  
	 6.14
		 Compliance with Laws
		 	11	  
	 6.15
		 Certain Payments
		 	11	  
	 6.16
		 Books and Records
		 	12	  
	 6.17
		 Investment Representations
		 	12	  
	 6.18
		 Astellas Agreement
		 	12	  
	 6.19
		 No Other Representations
		 	12	  

  
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	 ARTICLE 7 Representations and Warranties of Buyer
		 	13	  
		
	 ARTICLE 8 Covenants of the Parties
		 	21	  
			
	 8.1  
		 Public Announcements
		 	21	  
	 8.2  
		 Corporate Names
		 	22	  
	 8.3  
		 Regulatory Matters
		 	22	  
	 8.4  
		 Adverse Experience Reports
		 	22	  
	 8.5  
		 Affiliates
		 	22	  
	 8.6  
		 Access
		 	22	  
	 8.7  
		 Covenant Not to Sue; Non-Competition
		 	23	  
	 8.8  
		 Further Assurances
		 	25	  
	 8.9  
		 Tax Matters
		 	26	  
	 8.10
		 Market Stand-Off
		 	27	  
	 8.11
		 Reporting
		 	27	  
	 8.12
		 Diligence
		 	27	  
	 8.13
		 Insurance
		 	28	  
	 8.14
		 No Integration
		 	28	  
	 8.15
		 Additional Agreements
		 	28	  
		
	 ARTICLE 9 Indemnification
		 	28	  
			
	 9.1  
		 Survival of Representations, Warranties, Etc.
		 	28	  
	 9.2  
		 Indemnification
		 	29	  
	 9.3  
		 Limitations
		 	32	  
	 9.4  
		 Payments
		 	34	  
	 9.5  
		 Consequential Damages
		 	34	  
		
	 ARTICLE 10 Miscellaneous
		 	34	  
			
	 10.1  
		 Confidentiality
		 	34	  
	 10.2  
		 Notices
		 	35	  
	 10.3  
		 Entire Agreement
		 	36	  
	 10.4  
		 Waiver
		 	36	  
	 10.5  
		 Amendment
		 	36	  
	 10.6  
		 Third Party Beneficiaries
		 	36	  
	 10.7  
		 Assignment; Binding Effect
		 	36	  
	 10.8  
		 Headings
		 	37	  
	 10.9  
		 Severability
		 	37	  
	 10.10
		 Governing Law; Dispute Resolution
		 	37	  
	 10.11
		 Expenses
		 	37	  
	 10.12
		 Counterparts
		 	37	  
	 10.13
		 Schedules, Exhibits and Other Agreements
		 	38	  

  
 ii 

 ASSET PURCHASE AGREEMENT 

This Asset Purchase Agreement (this “Agreement”) is made and entered into as of March 17, 2015, by and between Ignyta,
Inc., a Delaware corporation (“Buyer”), and Cephalon, Inc., a Delaware corporation (“Seller”). 

RECITAL 
 WHEREAS, subject
to the terms and conditions of this Agreement, Seller desires to sell and assign to Buyer, and Buyer desires to purchase and assume from Seller, the Purchased Assets (as defined below) and the Assumed Liabilities (as defined below). 

AGREEMENT 
 NOW,
THEREFORE, in consideration of the premises and the mutual covenants and promises contained herein, and for other good and valuable consideration, the receipt and sufficiency of which hereby are acknowledged, the Parties agree as follows: 

ARTICLE 1 
 DEFINITIONS

 1.1             Defined Terms. Certain capitalized terms used in
this Agreement are defined in Exhibit A attached hereto. 

1.2             Construction of Certain Terms and Phrases. Unless the
context of this Agreement otherwise requires: (a) words of any gender include each other gender; (b) words using the singular or plural number also include the plural or singular number, respectively; (c) the terms “hereof,”
“herein,” “hereby” and derivative or similar words refer to this entire Agreement; (d) the terms “Article,” “Section” or “Exhibit” refer to the specified Article, Section or Exhibit of this
Agreement; (e) the term “or” has, except where otherwise indicated, the inclusive meaning represented by the phrase, “and/or”; and (f) the term “including” means “including without limitation.”
Whenever this Agreement refers to a number of days, such number shall refer to calendar days unless Business Days are specified. All accounting terms used but not otherwise defined herein shall have the meanings ascribed to such terms under GAAP,
consistently applied. The terms “US Dollars” and “$” shall mean lawful currency of the United States of America. 

ARTICLE 2 
 PURCHASE AND
SALE OF ASSETS 
 2.1             Purchase and Sale of Assets. 

(a)         Subject to the terms and conditions of this Agreement, at the Closing, Seller shall sell,
transfer, convey, assign and deliver to Buyer, free and clear of all Encumbrances (other than Permitted Encumbrances), and Buyer shall purchase, acquire and accept from Seller, all of Seller’s right, title and interest, as of the Closing, in
and to the Purchased Assets. 
 (b)         Notwithstanding anything contained in this Agreement to
the contrary, (i) from and after the Closing, Seller and its Affiliates shall retain all of their right, title and interest in and to the Excluded Assets, and (ii) Seller and its Affiliates may retain copies of all Assumed Contracts and
Books and Records which following the Closing may be used as contemplated herein (including to defend any indemnification claim hereunder or claim with respect to any Excluded Liability by a third party), for internal purposes and as required to
comply with applicable Laws (subject to Seller’s confidentiality obligations pursuant to Section 10.1 hereof). 

  
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 (c)         For those Compounds that (1) are
covered by clause (i) and not covered by clause (ii) of the definition of “Compounds,” in this Agreement and (2) do not have a Binding Affinity of less than three micromolar against any of the Buyer Targets, Seller hereby
retains, subject to Section 8.7(d), the right to use those Compounds (i.e., those satisfying clauses (1) and (2)) solely for its and its Affiliates’ internal research efforts. 

2.2             Assignability and Consents. Notwithstanding anything to the
contrary contained in this Agreement, if the sale, assignment, transfer, conveyance or delivery or attempted sale, assignment, transfer, conveyance or delivery to Buyer of any asset that would be a Purchased Asset is (a) prohibited by any
applicable Law or (b) would require any consents, waivers, approvals, authorizations of or notices to a third Person or Governmental or Regulatory Authority and such consents, waivers, approvals, authorizations or notices shall not have been
obtained prior to the Closing, then in either case the Closing shall proceed without the sale, assignment, transfer, conveyance or delivery of such asset, or assumption of such contract, and this Agreement shall not constitute an agreement for the
sale, assignment, transfer, conveyance or delivery of such asset or assumption of such contract. In the event that the Closing proceeds without the sale, assignment, transfer, conveyance or delivery of any such asset or assumption of such contract,
then for six (6) months following the Closing, the Parties shall use their commercially reasonable efforts, and cooperate in good faith with each other, to obtain promptly such consents, waivers, approvals, authorizations or notices;
provided, that in no event shall Seller or its Affiliates have any obligation to offer or pay any consideration, commence any litigation or grant any third party any accommodation (financial or otherwise) in order to obtain any such consents,
waivers, approvals, authorizations or notices. Pending such consents, waivers, approvals, authorizations or notices, the Parties shall cooperate with each other in any mutually agreeable, reasonable and lawful arrangement, and as permitted under the
applicable Contract, designed to provide to Buyer the benefits of use of such asset and to Seller the benefits, including any indemnities, that, in each case, it would have obtained had the asset been conveyed to Buyer at the Closing. To the extent
that Buyer is provided the benefits pursuant to this Section 2.2 of any Contract, Buyer shall (x) perform for the benefit of the other parties thereto the obligations of Seller or any Affiliate of Seller thereunder and (y) shall
satisfy any related Liabilities with respect to such Contract that, but for the lack of an authorization, approval, consent or waiver to assign such obligations or Liabilities to Buyer, would be Assumed Liabilities. Once consent, waiver, approval,
authorization or notice for the sale, assignment, transfer, conveyance or delivery of any such asset not sold, assigned, transferred, conveyed or delivered at the Closing is obtained or given, Seller shall assign, transfer, convey and deliver such
asset to Buyer at no additional cost to Buyer. 
 ARTICLE 3 

ASSUMPTION OF ASSUMED LIABILITIES 

Subject to the terms and conditions of this Agreement, as of the Closing Date, Buyer will deliver the Assignment and Assumption Agreement to
Seller pursuant to which Buyer agrees to assume and timely satisfy, perform, pay and discharge, and otherwise be responsible for, the Assumed Liabilities. Except with respect to the Assumed Liabilities and as expressly set forth herein or in any
other Transaction Document, Buyer shall not assume and shall not in any way be responsible for any of the debts, liabilities, or obligations of Seller as a result of the transactions contemplated hereby. 

  
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 ARTICLE 4 

PURCHASE PRICE AND PAYMENT 

4.1             Purchase Price. As consideration for the Purchased Assets
and Seller’s full and faithful performance of all of its obligations hereunder, Buyer shall at the Closing: 

(a)         issue to Seller (or its designee that is an Affiliate of Seller) One Million Five Hundred
Thousand (1,500,000) shares (the “Shares”) of Buyer Common Stock for the Purchased Assets other than the Product Inventory; 

(b)         pay to Seller by wire transfer of immediately available funds an amount equal to
$851,987.90 for the Product Inventory (together with the issuance of the Shares, the “Purchase Price”); and 

(c)         assume the Assumed Liabilities pursuant to the Assignment and Assumption Agreement. 

4.2             Purchase of Compound Inventory and Product Inventory. On
the Closing Date, Buyer shall take title to all Compound Inventory and Product Inventory. As promptly as possible after the Closing, Seller and Buyer shall determine the procedures for the transfer of all Product Inventory to Buyer or Buyer’s
designee following the Closing. 
 4.3             Payment of Sales, Use and
Other Taxes. Seller and Buyer shall each be responsible for fifty percent (50%) of all sales, use, transfer, value added, documentary and other similar Taxes, if any, arising out of the sale of the Purchased Assets to Buyer pursuant to this
Agreement (collectively, the “Transaction Taxes”). Buyer and Seller agree to cooperate to determine the amount of any Transaction Taxes payable in connection with the transfer of the Purchased Assets under this Agreement. Buyer and
Seller agree to assist each other, to the extent reasonably necessary and appropriate, in the preparation and filing of any and all required Tax Returns related to Transaction Taxes. 

4.4             Allocation of Purchase Price; Tax Treatment. 

(a)         The Purchase Price (plus Assumed Liabilities, to the extent properly taken into account
under the Code), shall be allocated among the Purchased Assets and the covenant not to compete contained in Section 8.7 in accordance with Section 1060 of the Code and the Treasury Regulations promulgated thereunder (and any similar
provision of state, local or foreign law, as appropriate) (the “Allocation”). For purposes of the foregoing, the Shares shall be valued at $10.00 per share and the amount allocated to the Product Inventory shall equal that described
in Section 4.1(b). The Allocation shall be delivered by Buyer to Seller within sixty (60) days after the Closing Date. Seller and Buyer shall work in good faith to resolve any disputes relating to the Allocation within twenty
(20) days. If Seller and Buyer are unable to amicably resolve any such dispute, such dispute shall be resolved promptly by an independent certified public accountant (“Independent Accountant”) agreed upon by the parties, such
agreement not to be unreasonably withheld or delayed, the costs of which shall be borne equally by Seller and Buyer. 

(b)         If the Purchase Price is adjusted pursuant to Section 8.9 or Article 9, the
Allocation shall be adjusted in a manner consistent with Section 1060 of the Code. However, if the Parties are unable to amicably agree on such adjustment, such dispute shall be resolved promptly by an Independent Accountant agreed upon by the
parties, such agreement not to be unreasonably withheld or delayed, the costs of which shall be borne equally by Buyer and Seller. 

  
 3 

 (c)        Buyer and Seller agree (i) to report the
sale and purchase of the Purchased Assets for federal and state Tax purposes in accordance with the Allocation and (ii) not to take any position inconsistent with such Allocation on any of their respective Tax Returns, unless otherwise required
by applicable Law or by a final determination (as defined in Section 1313(a) of the Code), or unless the other party consents thereto, which consent shall not be unreasonably withheld or delayed. 

(d)        Buyer and Seller agree to treat the sale of the Purchased Assets as a taxable transaction
for federal and state Tax purposes and not to take any position inconsistent with such treatment on any of their respective Tax Returns. 

4.5             Withholding. Buyer shall be entitled to deduct and withhold
from the consideration otherwise payable pursuant to this Agreement such amounts as Buyer is required to deduct and withhold under the Code, or any Tax law, with respect to the making of such payment; provided, however, that Buyer will use
reasonable efforts to give Seller advance notice of any such deduction or withholding. To the extent that amounts are so deducted and withheld, such amounts shall be treated for all purposes of this Agreement as having been paid to Seller. 

ARTICLE 5 
 CLOSING

 5.1             Time and Place. The closing of the transactions
contemplated by this Agreement, including the purchase and sale of the Purchased Assets and the assumption of the Assumed Liabilities (the “Closing”), shall take place remotely via the exchange of documents and signature pages on
the date hereof (the “Closing Date”), unless another time or place shall be agreed to by the Parties. 

5.2             Deliveries at Closing. 

(a)         Closing Deliveries by Seller. At the Closing, Seller shall deliver or cause to be
delivered to Buyer: 
 (i)         an intellectual property assignment, substantially in the form
of Exhibit B hereto (the “Intellectual Property Assignment Agreement”); 

(ii)         an assignment and assumption agreement, substantially in the form of Exhibit C
hereto(the “Assignment and Assumption Agreement”); 
 (iii)         a bill of
sale, substantially in the form of Exhibit D hereto (the “Bill of Sale”); and 

(iv)         completed and executed copies of the documents referred to in Section 8.9(d). 

(b)         Closing Deliveries by Buyer. At the Closing, Buyer shall deliver or cause to be
delivered to Seller: 
 (i)         the Intellectual Property Assignment Agreement; 

(ii)         the Assignment and Assumption Agreement; 

(iii)         such instruments of assumption and other instruments or documents, in form and
substance reasonably acceptable to Seller and Buyer, as may be reasonably necessary to effect Buyer’s assumption of the Assumed Liabilities in accordance with the terms of this Agreement and the Assignment and Assumption Agreement; 

  
 4 

 (iv)         copies of all Buyer Governmental Consents
and Buyer Third Party Consents; 
 (v)         written irrevocable instructions executed by a duly
authorized officer of Buyer directing its transfer agent to issue to Seller, or in such nominee name(s) as designated by Seller in writing, the Shares (such Shares to be certificated and delivered to Austin Kim at the notice address of Seller
promptly following the Closing); 
 (vi)         a registration rights agreement, substantially in
the form of Exhibit F hereto (the “Registration Rights Agreement”); 

(vii)         an opinion, dated as of the Closing Date, from Latham & Watkins LLP, counsel
to Buyer, in the form of Exhibit H hereto; 
 (viii)         Buyer Common Stock shall not
have been suspended, as of the Closing Date, by the SEC or Nasdaq from trading on Nasdaq nor shall suspension by the SEC or Nasdaq have been threatened, as of the Closing Date, either (i) in writing by the SEC or Nasdaq or (ii) by falling
below the minimum listing maintenance requirements of Nasdaq; 
 (ix)         Buyer shall have
obtained all necessary blue sky law permits and qualifications, or secured exemptions therefrom, required by an state or foreign or other jurisdiction for the offer and sale of the Shares; and 

(x)         the Shares to be issued shall be duly authorized for listing by Nasdaq, subject to
official notice of issuance, to the extent required by the rules of Nasdaq. 
 ARTICLE 6 

REPRESENTATIONS AND WARRANTIES OF SELLER 

Seller represents and warrants to Buyer as of immediately prior to the Closing, subject to such exceptions as either (a) are specifically
disclosed in the disclosure schedule referencing the appropriate Section or Sections hereof (or as otherwise deemed disclosed as contemplated by Section 10.13) as shall be supplied by Seller to Buyer and dated as of the date hereof (the
“Seller Disclosure Schedule”) or (b) are disclosed in the Seller Dataroom prior to 9:00 a.m. ET on March 16, 2015, as follows: 

6.1             Organization, Etc. Seller is a corporation duly
incorporated, validly existing and in good standing under the laws of the State of Delaware, and has all requisite corporate power and authority (a) to conduct the Programs in the manner in which they are currently being conducted, and
(b) to own and use its assets in the manner in which its assets are currently owned and used. Seller does not have any subsidiaries, direct or indirect that own or control or otherwise have any rights with respect to the Purchased Assets. 

6.2             Authority; Binding Nature. Seller has all necessary power
and authority and has taken all actions necessary to enter into this Agreement and the other Transaction Documents and to carry out the transactions and perform the obligations contemplated hereby and thereby. Each of this Agreement and the other
Transaction Documents has been duly and validly authorized, executed and delivered by Seller and, when executed and delivered by Buyer, will constitute a legal, valid and binding obligation of Seller enforceable against it in accordance with its
terms except (a) as limited by applicable bankruptcy, 

  
 5 

 
insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally, and (b) as limited by laws relating to the
availability of specific performance, injunctive relief or other equitable remedies. 

6.3             Non-Contravention; Consents. Except as set forth in
Section 6.3 of the Seller Disclosure Schedule, the execution, delivery and performance of this Agreement and each of the other Transaction Documents and the sale of the Purchased Assets to Buyer do not and will not materially contravene,
materially conflict with or result in a material violation of any (a) Laws applicable to the Purchased Assets, any Assumed Contract or the Programs; (b) any provision of an Assumed Contract; or (c) any of the provisions of
Seller’s organizational documents or any resolution adopted by Seller’s Board of Directors (or any committee thereof) or stockholders. The execution, delivery and performance by Seller of this Agreement will not result in the imposition of
any Encumbrance on the Purchased Assets. Except as disclosed in Section 6.3 of the Seller Disclosure Schedule, no Seller Third Party Consent or Seller Governmental Consent is required for or in connection with the execution, delivery or
performance of this Agreement and each of the other Transaction Documents by Seller. 

6.4             Reserved. 

6.5             Title to Purchased Assets. Seller has good and marketable
title to all of the Purchased Assets, including the Compound Inventory and the Product Inventory, free and clear of all Encumbrances (other than Permitted Encumbrances), and to Seller’s Knowledge, Seller has not received any written notice of
any adverse claim challenging or asserting ownership or inventorship of any Purchased Asset. 

6.6             Assumed Contracts. 

(a)       Section 6.6 of the Seller Disclosure Schedule sets forth a true, accurate and complete list of
each Contract to which Seller is a party that is currently in effect and (i) is material to the conduct of the Programs as currently conducted by Seller, and (ii) is related to the Compounds, Current Products, the conduct of the Programs
or the Purchased Assets and falls within one or more of the following categories: 
 (i) Contracts under which the Compounds or Current
Products were discovered, reduced to practice, tested, characterized, designed, developed, manufactured or distributed by Seller (other than agreements with employees of Seller or its Affiliates); 

(ii) Contracts limiting or restraining Seller from engaging or competing in any lines of business with any Person or from purchasing any
products, services or inventory from any third parties, in each case, directly relating to the Current Compounds, Current Products or the conduct of the Programs; and 

(iii) any other Contract if a default thereunder could be expected to have an Adverse Effect on the ability to conduct the Programs. 

(b)      (i) Seller is not presently in material violation or breach of, and has not declared or committed any
material default under (and would not by the lapse of time or the giving of notice or both, be in breach or default) and, to the Knowledge of Seller, no Person is presently in material violation or breach of, or has declared or committed any
material default under (and would not by the lapse of time or the giving of notice or both, be in breach or default), any Assumed Contract, (ii) no event has occurred, and no circumstance or condition exists (including the Closing of the
transactions contemplated by this Agreement), that would give any Person the right to cancel, terminate or modify any Assumed Contract, (iii) each Assumed Contract sets forth the entire agreement and understanding

  
 6 

 
between Seller and the other parties thereto and is valid, binding and in full force and effect and (iv) none of the Assumed Contracts have been entered into by Seller other than in the
ordinary course of its business and other than on an arm’s length basis. Seller has made available to Buyer complete and correct copies of all Assumed Contracts. Seller has no Knowledge that any party to any Assumed Contract listed in
Section 6.6 of the Seller Disclosure Schedule (or required to be listed on such schedule) (i) intends to either terminate or not renew such Assumed Contract, or (ii) has or intends to submit to Seller any claim of breach by any such
party with respect to the performance of its obligations under any such Assumed Contract. 

(c)         Section 6.6(c) of the Seller Disclosure Schedule sets forth a list of the Assumed
Contracts. 
 6.7             Intellectual Property Rights. 

(a)         Section 6.7(a) of the Seller Disclosure Schedule sets forth a true and complete list
of all of the Registered Intellectual Property, all of which is owned or Controlled by and registered in the name of the Seller except as otherwise disclosed therein. With respect to Registered Intellectual Property, Section 6.7(a) of the
Seller Disclosure Schedule also sets forth: for each issued Patent within the Patents, the number, and the jurisdiction in which such Patent has been issued, validated, or extended, or, if applicable, for each pending patent application within
the Patents, the patent application number, date of filing, status and jurisdiction in which each application is pending. 

(b)         Seller owns all right, title and interest in and to the Registered Intellectual Property
set forth on Section 6.7(a) of the Seller Disclosure Schedule, free and clear of all Encumbrances other than Permitted Encumbrances, provided, however, that in the case of Registered Intellectual Property licensed from other Persons
under licenses that are disclosed on Section 6.7(c) of the Seller Disclosure Schedule, the scope of rights licensed to Seller is set forth in such licenses. 

(c)         Section 6.7(c) of the Seller Disclosure Schedule sets forth a true and complete list
of all Contracts containing either (i) a license of (or covenant not to sue, non-assertion, settlement or similar agreements or consents related to) Registered Intellectual Property to a third party, or (ii) a license of (or covenant not
to sue, non-assertion, settlement or similar agreements or consents related to) Registered Intellectual Property by a third party to Seller (and in each case that have not, prior to the date hereof, expired or been terminated pursuant to their terms
or operation of law). A true and correct copy of each such Contract has been provided or made available to Buyer. Except as set forth in Section 6.7(c) of the Seller Disclosure Schedule all of such Contracts are Assumed Contracts. Such
Contracts are legal, valid, binding, enforceable obligations of Seller and, to the Knowledge of Seller, the other parties thereto, in accordance with their terms, except as such enforceability may be limited by (y) bankruptcy, insolvency,
moratorium, reorganization and other similar laws affecting creditors’ rights generally and (z) the general principles of equity, regardless of whether asserted in a proceeding in equity or at law. Such Contracts are in full force and
effect, and to the Knowledge of Seller the underlying Registered Intellectual Property for each such Contract is not subject to any outstanding injunction, judgment, order, decree or ruling. The Assumed Contracts accurately reflect all royalties,
fees, costs and similar payments that Seller is obligated to pay to any third party who owns or is a licensee of any Registered Intellectual Property or whose intellectual property is licensed to Seller under an Assumed Contract and was used to
develop or Exploit any Compound or Current Product, and except as set forth therein, Seller is not obligated or under any liability whatsoever to make any payments by way of royalties, fees, costs or otherwise to any owner or licensee of, or other
claimant to, any such Registered Intellectual Property or under the Assumed Contracts. 

  
 7 

 (d)         The issued Registered Intellectual Property
is subsisting, in full force and effect, and, to the Knowledge of Seller, valid and enforceable, and is not subject to any pending or, to the Knowledge of Seller, threatened action, suit, proceeding, hearing, investigation, charge, complaint, claim,
or demand that challenges the validity, enforceability, scope, registration, ownership, inventorship or use of the item. The issued Registered Intellectual Property has not expired or been cancelled or abandoned, and is not subject to any pending
or, to the Knowledge of Seller, threatened action, suit, proceeding, hearing, investigation, charge, complaint, claim, demand, opposition, cancellation, interference, reexamination, inter partes review, post-grant review, derivation or
similar judicial or administrative proceeding in any forum. There are no past due registration, maintenance or renewal fees that are necessary to be paid in connection with the Registered Intellectual Property, and all necessary documents,
recordations and certificates in connection with the issued Registered Intellectual Property have been validly executed, delivered or timely filed with the relevant patent office or other Governmental or Regulatory Authorities in the United States
or foreign jurisdictions, as the case may be, for the purposes of perfecting Seller’s rights in and maintaining such issued Registered Intellectual Property. 

(e)         Seller has taken reasonable steps to obtain, maintain, police and protect the Registered
Intellectual Property and to maintain and protect the confidentiality of the Know-How, in each case, consistent with Seller’s normal practices with respect to Seller’s other similar intellectual property, which practices include having
employees, consultants and contractors of Seller or other Persons that have participated in the discovery, reduction to practice, creation or development of any intellectual property for Seller execute assignment agreements in which they irrevocably
assign or otherwise vest all of their rights in and to such intellectual property to Seller. 

(f)         No interest in any of the Registered Intellectual Property has been assigned,
transferred, licensed or sublicensed by Seller to any Person, nor has Seller agreed not to assert or to permit any third party to assert any Registered Intellectual Property against any Person. Except as set forth in Section 6.7(c) of the
Seller Disclosure Schedule, Seller has not executed or granted to any third party, directly or indirectly, or entered into any agreement for, any license or other right to Exploit the Compounds or Products. 

(g)         None of the Registered Intellectual Property is subject to any outstanding and final
order, judgment, decree or stipulation from a Government or Regulatory Authority having jurisdiction over Seller restricting the use thereof by Seller with respect to the Programs or restricting the licensing thereof by Seller to any Person. 

(h)         Other than ordinary course ex parte prosecution activities before national or regional
patent offices relating to pending patent applications within the Registered Intellectual Property, no interferences, oppositions, reissues, reexaminations or other Actions or Proceedings of any nature are pending or have been threatened in writing
in which the scope, validity, ownership, inventorship, or enforceability of any of the pending Registered Intellectual Property is being or has been contested or challenged. The pending Registered Intellectual Property is subsisting and has not
expired or gone abandoned. All pending Registered Intellectual Property has been timely filed, and no necessary fees for the pending Registered Intellectual Property are past due. 

(i)         Except as set forth in Section 6.7(i) of the Seller Disclosure Schedule, there are
no filings, responses, fees, or any other actions with a final due date concerning any pending Registered Intellectual Property within ninety (90) days from the Closing Date. 

(j)         Seller has taken all reasonable and prudent steps to protect the Registered Intellectual
Property from infringement by any other Person. To the Knowledge of Seller, no other Person is claiming any ownership of or right to use any of the Intellectual Property. Seller has not made 

  
 8 

 
any claim of any unauthorized use, unauthorized disclosure, infringement, dilution, violation or misappropriation by others of its rights in the Intellectual Property, and, to the Knowledge of
Seller, no grounds for any such claims exist. 
 (k)         To the Knowledge of Seller, the
conduct of the Programs and the Exploitation of the Compounds and Current Products have not, do not and will not infringe, dilute, conflict with, misappropriate, or otherwise violate any intellectual property rights of any Person, violate any right
to privacy or publicity, nor constitute unfair competition or trade practices under the Laws of any jurisdiction. Seller has not received notice from any Person claiming that the conduct of the Programs or the Exploitation of the Compounds and/or
Current Products infringes, dilutes, conflicts with, misappropriates or otherwise violates the intellectual property rights of any Person under the Laws of any jurisdiction. 

(l)         Except with respect to the Non-Assert IP, the Registered Intellectual Property
constitutes all issued Patents and pending applications for the Patents owned or Controlled by Seller relating to the Programs, or the Exploitation of the Compounds or Current Products. 

(m)         Within ninety (90) days from the Closing Date, Seller shall provide Buyer with
(i) a copy of each draft patent application that claims Compounds or Current Products and (ii) a copy of each invention disclosure form or similar document that claims Compounds or Current Products that are in the possession of Seller as
of the Closing Date. 
 6.8             Litigation. There are no pending
Actions or Proceedings and, to the Knowledge of Seller, no Person has threatened in writing to commence any Action or Proceeding, (a) that involves the Purchased Assets; or (b) that challenges, or that may have the effect of preventing,
delaying, making illegal or otherwise interfering with, the transactions contemplated by this Agreement. There are, and there have been, no claims made in writing against Seller alleging any material defects in one or more Current Products or the
Product Inventory or alleging any failure of one or more Current Products or the Product Inventory to meet required specifications. 

6.9             Permits; Regulatory Compliance. 

(a)         Section 6.9(a) of the Seller Disclosure Schedule contains a complete and accurate
list of each Regulatory Filing made or held by Seller for the Current Compounds and Current Products resulting from the Programs as currently conducted by Seller and material license, registration, franchise, application, permit or other similar
authorization obtained by Seller to conduct the Programs as currently conducted by or on behalf of Seller, together with the name of the Governmental or Regulatory Authority issuing such license or permit (the “Permits”) made or
held by Seller. Each such Permit is valid and in full force and effect, except as could not be expected to have an Adverse Effect on the ability to conduct the Programs. Seller has fulfilled and performed all of its material obligations with respect
to the Permits, and no event has occurred, and Seller has not received any notice in writing from any Governmental or Regulatory Authority or otherwise of the occurrence of any event, that will constitute a violation of or a failure to comply with
any term or requirement of any such Permit, or that would allow, or after notice or lapse of time would allow, the revocation, withdrawal, suspension, cancellation, or termination of any such Permit, except as could not be expected to have an
Adverse Effect on the ability to conduct the Programs. 
 (b)        (i) Seller has furnished Buyer
with access to complete copies of all INDs included in the Purchased Assets, (ii) Seller is and was, at all times prior to the Closing Date, the lawful holder of all rights under the such INDs, (iii) Seller has complied in all material
respects with applicable Laws relating to such INDs , and with regard to actions taken directly by Seller, relating to the Current 

  
 9 

 
Compounds and Current Products, (iv) such INDs are effective, and nothing has come to Seller’s attention that has, or reasonably should have, led Seller to believe that such INDs are
not in good standing with relevant regulatory authorities, (v) Seller has filed with the relevant Governmental or Regulatory Authorities all required notices, supplemental applications and annual or other reports, including adverse experience
reports, with respect to such INDs, and (vi) there is no pending or, to the Knowledge of Seller, overtly threatened action by any relevant Government or Regulatory Authority that could be expected to have an Adverse Effect on the ability to
conduct the Programs. 
 (c)         The clinical, pre-clinical and other studies and tests
conducted by or on behalf of or sponsored by Seller or in which the Current Compounds and Current Products have participated were and, if still pending, are being conducted in all material respect in accordance with standard medical and scientific
research procedures and all applicable Laws, including, but not limited to, the Federal Food, Drug and Cosmetic Act and its applicable implementing regulations at 21 C.F.R. Parts 50, 54, 56, 58 and 312. Except to the extent disclosed on
Section 6.9(c) of the Seller Disclosure Schedule, no IND included in the Purchased Assets and filed by or on behalf of Seller with the FDA has been terminated or suspended by the FDA, and neither the FDA nor any applicable foreign Government or
Regulatory Authority has commenced, or, to the Knowledge of Seller, threatened to initiate, any action to place a clinical hold order on, or otherwise terminate, delay or suspend, any proposed or ongoing clinical investigation conducted or proposed
to be conducted by or on behalf of Seller. 
 (d)         None of the executive officers of Seller
have been disqualified or debarred by any Government or Regulatory Authority for any purpose, or have been charged with or convicted under any Law for conduct relating to the development or approval or otherwise relating to the regulation of any
drug product under any Law; and (ii) Seller is not the subject of any pending or, to the Knowledge of Seller, threatened investigation in respect of Seller or the Current Compounds or Current Products by the FDA pursuant to its “Fraud,
Untrue Statements of Material Facts, Bribery, and Illegal Gratuities” Final Policy set forth in 56 Fed. Reg. 46191 (September 10, 1991) and any amendments thereto. 

6.10             Compound and Product Inventory. 

(a)         Section 6.10(a) of the Seller Disclosure Schedule lists (i) the lot numbers
associated with the Product Inventory and (ii) the manufacturing, warehousing, distribution and consignee locations where the Product Inventory is located. Seller represents and warrants that the Product Inventory manufactured by or for Seller
that will be provided to Buyer hereunder was manufactured, packaged and stored in compliance with all relevant, applicable Laws, including those governing clinical biopharmaceutical supplies, and to the Knowledge of Seller, are of good manufacturing
quality. 
 (b)         The Product Inventory represents all drug substance and drug product
exclusively related to Products that is currently owned and on hand or in the control of Seller at any of its warehouses, blenders, toll manufacturers, suppliers, or other third parties. 

(c)         Section 6.10(c) of the Seller Disclosure Schedule lists the Seller identifiers,
amounts and chemical structures of Compounds comprising the Compound Inventory. 

6.11             Product Data. Seller represents and warrants that the
Product Data included within the Purchased Assets are true and complete in all material respects. 

6.12             Brokers. Seller has not retained any broker in connection
with the transactions contemplated hereunder. No broker, finder or investment banker is entitled to any brokerage, finder’s or other fee or commission in connection with the transactions contemplated by this Agreement or any other Transaction
Document based upon arrangements made by or on behalf of Seller. 

  
 10 

 6.13             Taxes. 

(a)         Seller has duly and timely filed with the appropriate Tax authorities all Tax Returns
required to be filed with respect to the Purchased Assets or the Programs. All such Tax Returns are complete and accurate in all material respects. All Taxes due and owing with respect to the Purchased Assets or the Programs (whether or not shown on
any Tax Returns) have been paid. 
 (b)         No deficiencies for Taxes with respect to the
Purchased Assets or the Programs have been claimed, proposed or assessed by any Tax authority or other Governmental Authority. There are no pending or, to the Knowledge of Seller, threatened audits, assessments or other actions for or relating to
any Liability in respect of Taxes with respect to the Purchased Assets or the Programs. 

(c)         There are no Encumbrances for Taxes on the Purchased Assets (other than Permitted
Encumbrances). 
 (d)         There are no Tax sharing agreements or similar arrangements
(including indemnity arrangements) with respect to or involving the Purchased Assets or the Programs. 

(e)         No Purchased Asset (i) is property required to be treated as owned by another person
pursuant to the provisions of Section 168(f)(8) of the Internal Revenue Code of 1954, as amended and in effect immediately prior to the enactment of the Tax Reform Act of 1986, (ii) constitutes “tax-exempt use property” within
the meaning of Section 168(h) of the Code, (iii) is “tax-exempt bond financed property” within the meaning of Section 168(g) of the Code, (iv) secures any debt the interest of which is tax-exempt under
Section 103(a) of the Code or (v) is subject to a “section 467 rental agreement” as defined in Section 467 of the Code. 

(f)         No part of the Purchase Price payable hereunder will be considered an amount received
from the sale, exchange or other disposition of a “United States real property interest” (within the meaning of Section 897(c) of the Code) subject to the provisions of Section 897(a) or Section 1445(a) of the Code. 

6.14             Compliance with Laws. 

(a)         Seller is, and at all times since January 1, 2012 has been, in material compliance
with all applicable Laws relating to the development of any Current Compound or Current Product and the Purchased Assets; 

(b)         Seller is conducting, and at all times since January 1, 2012 has conducted, the
Programs in material compliance with all applicable Laws; and 
 (c)         no written notices
have been received by, and no claims have been filed against, Seller alleging a violation of any applicable Laws relating to any Current Compound or Current Product and the Purchased Assets. 

6.15             Certain Payments. Neither Seller nor any of its
Affiliates, nor to Seller’s Knowledge any other Person acting for or on behalf of any of them, has directly or indirectly with respect to the Programs, Current Compounds, Current Products or Purchased Assets made any contribution, gift, bribe,
payoff, influence payment, kickback, or other similar payment to any governmental official or employee, regardless of form, whether in money, property, or services (i) to obtain favorable treatment in securing business, (ii) to pay for
favorable treatment for business secured, (iii) to obtain special concessions or for special concessions already obtained, for or in respect of Seller or the Programs, or (iv) in violation of any applicable Law. 

  
 11 

 6.16             Books and
Records. Seller has maintained books and records relating to its operation of the Programs that are true, accurate and complete in all material respects, and there are no material deficiencies in such books and records. 

6.17             Investment Representations. 

(a)       The issuance of the Shares by Buyer is made in reliance upon Seller’s representation to Buyer,
which by Seller’s execution of this Agreement Seller hereby confirms, that the Shares to be received by Seller will be acquired for investment for Seller’s own account, not as a nominee or agent, and not with a view to the sale or
distribution of any part thereof. By executing this Agreement, Seller further represents that it has no contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participation to such person or to any third party,
with respect to any of the Shares; 
 (b)       Except as may be required pursuant to the Registration Rights
Agreement, Seller understands and acknowledges that the issuance and sale of the Shares pursuant to this Agreement will not be registered under the Securities Act on the grounds that the offering and sale of securities contemplated by this Agreement
are exempt from registration pursuant to Section 4(a)(2) of the Securities Act and that the Shares may not be resold except upon their subsequent registration or pursuant to an exemption from the registration requirements, and that Buyer’s
reliance upon such exemption is predicated upon Seller’s representations as set forth in this Agreement; and 

(c)       Seller represents that: (i) it is an “accredited investor” as such term is defined in
Regulation D under the Securities Act and, to the best of its knowledge, has such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of its prospective investment in the Shares;
(ii) it believes it has received all the information it has requested from Buyer and considers necessary or appropriate for deciding whether to obtain the Shares; (iii) it has had the opportunity to discuss Buyer’s business,
management, and financial affairs with Buyer’s management; (iv) it has the ability to bear the economic risks of its prospective investment; and (v) it is able, without materially impairing its financial condition, to hold the Shares
for an indefinite period of time and to suffer a complete loss on its investment. 

6.18             Astellas Agreement. To the Knowledge of Seller, Seller has
not used any Scientific Information or Data (as such terms are defined in the Astellas Agreement) licensed to Seller pursuant to the Astellas Agreement in connection with Seller’s CEP-40125 program. 

6.19             No Other Representations. SELLER MAKES NO REPRESENTATION
OR WARRANTY OTHER THAN AS SET FORTH IN THIS AGREEMENT AS TO COMPOUNDS, PRODUCTS, THE PURCHASED ASSETS, THE INTELLECTUAL PROPERTY, THE ASSUMED CONTRACTS OR THE PROGRAMS (INCLUDING, BUT NOT LIMITED TO, THE PRODUCT INVENTORY) OR ITS BUSINESS, WHETHER
EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR INFRINGEMENT OF THIRD PARTY RIGHTS, AND ALL SUCH WARRANTIES ARE EXPRESSLY DISCLAIMED. 

  
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 ARTICLE 7 

REPRESENTATIONS AND WARRANTIES OF BUYER 

Buyer represents and warrants to Seller as of immediately prior to the Closing, subject to such exceptions as either (a) are specifically
disclosed in the disclosure schedule referencing the appropriate Sections hereof (or as otherwise deemed disclosed as contemplated by Section 10.13) supplied by Buyer to Seller and dated as of the date hereof (the “Buyer Disclosure
Schedule”) or (b) are disclosed in the SEC Reports, as follows: 
 (a)         Buyer
and each of its Subsidiaries (as defined below) has been duly organized and is validly existing as a corporation in good standing (or the foreign equivalent thereof) under the laws of its jurisdiction of organization. Buyer and each of its
Subsidiaries is duly qualified to do business and is in good standing as a foreign corporation in each jurisdiction in which its ownership or lease of property or the conduct of its business requires such qualification and has all power and
authority necessary to own or hold its properties and to conduct the business in which it is engaged, except where the failure to so qualify, be in good standing or have such power or authority (i) would not have, individually or in the
aggregate, a material adverse effect on the condition (financial or otherwise), results of operations, assets, properties or business or prospects of Buyer, taken as a whole, or (ii) impair in any material respect the ability of Buyer to
perform its obligations under this Agreement or to consummate any transactions contemplated by the Agreement (any such effect as described in clauses (i) or (ii), a “Material Adverse Effect”). 

(b)         Buyer has no subsidiaries other than those set forth in the SEC
Reports (collectively, the “Subsidiaries”). Except as set forth in the SEC Reports, Buyer owns, directly or indirectly, all of the equity interests of the Subsidiaries free and clear of any lien, charge, security interest,
encumbrance, right of first refusal or other restriction, and all the equity interests of the Subsidiaries are validly issued and are fully paid, nonassessable and free of preemptive and similar rights. 

(c)         Neither Buyer nor any of its Subsidiaries is (i) in violation of its articles or
by-laws or similar organizational documents; (ii) in default, and no event has occurred that, with notice or lapse of time or both, would constitute such a default, in the due performance or observance of any term, covenant or condition
contained in any indenture, mortgage, deed of trust, loan agreement or other agreement or instrument to which Buyer or any of its Subsidiaries is a party or by which Buyer or any of its Subsidiaries is bound or to which any of the property or assets
of Buyer or any of its Subsidiaries are subject; or (iii) in violation of any law or statute or any judgment, order, rule or regulation of any court or arbitrator or governmental or regulatory authority, except, in the case of each of clauses
(ii) and (iii) above, for any such violation or default that would not, individually or in the aggregate, have a Material Adverse Effect. To Buyer’s knowledge, no other party under any material contract or other agreement to which it
or any of its Subsidiaries is a party is in default in any respect thereunder where such default would have a Material Adverse Effect. 

(d)         Subsequent to the respective dates as of which information is given in the SEC Reports,
if any, there has not been (i) any Material Adverse Effect or the occurrence of any development that Buyer reasonably expects will result in a Material Adverse Effect, (ii) other than as contemplated by this Agreement any transaction which
is material to Buyer and the Subsidiaries taken as a whole, (iii) any obligation or liability, direct or contingent (including any off-balance sheet obligations), incurred by Buyer or any Subsidiary, which is material to Buyer and the
Subsidiaries taken as a whole, (iv) any material change in the capital stock (other than as a result of the sale of the Shares) or outstanding long-term indebtedness of Buyer or any of its Subsidiaries or (v) any dividend or distribution
of any kind declared, paid or made on the capital stock of Buyer or any Subsidiary, other than in each case above in the ordinary course of business or as otherwise disclosed in the SEC Reports. 

  
 13 

 (e)         Buyer has the full right, power and
authority to enter into this Agreement and to perform and to discharge its obligations hereunder and thereunder; and this Agreement has been duly authorized, executed and delivered by Buyer, and constitutes a valid and binding obligations of Buyer
enforceable in accordance with its terms, except as may be limited by bankruptcy, insolvency, reorganization or other similar laws relating to enforcement of creditors’ rights generally and by general principles of equity. 

(f)         Buyer has an authorized capitalization as set forth in the SEC Reports, and all of the
issued shares of capital stock of Buyer have been duly authorized and validly issued, are fully paid and non-assessable, have been issued in all material respects in compliance with United States federal and state securities laws, and conform
to the description thereof contained in the SEC Reports. As of March 16, 2015, there were 19,584,769 shares of Common Stock issued and outstanding, no shares of Preferred Stock, par value $0.0001 of Buyer, issued and outstanding and
3,943,286 shares of Common Stock were issuable upon the exercise of all options, warrants and convertible securities outstanding as of such date. All of Buyer’s options, warrants and other rights to purchase or exchange any securities for
shares of Buyer’s capital stock have been duly authorized and validly issued and were issued in all material respects in compliance with United States federal and state securities laws. None of the outstanding shares of Common Stock was issued
in violation of any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase securities of Buyer. There are no authorized or outstanding shares of capital stock, options, warrants, preemptive rights, rights of
first refusal or other rights to purchase, or equity or debt securities convertible into or exchangeable or exercisable for, any capital stock of Buyer other than those described above or accurately described in the SEC Reports. The
description of Buyer’s stock option, stock bonus and other stock plans or arrangements, and the options or other rights granted thereunder, as described in the SEC Reports, accurately and fairly present in all material respects the
information required to be shown with respect to such plans, arrangements, options and rights. 

(g)         The shares of Common Stock to be issued and sold by Buyer to Seller under the Agreement
have been duly authorized and the Common Stock, when issued and delivered against payment therefor as provided in the Agreement will be validly issued, fully paid and non-assessable and free of any preemptive or similar rights and will conform to
the description thereof contained in the SEC Reports. 
 (h)         The execution, delivery and
performance of the Agreement by Buyer, the issue and sale of the shares of Common Stock by Buyer and the consummation of the transactions contemplated hereby will not (with or without notice or lapse of time or both): (i) result in
any violation of the provisions of the articles or by-laws (or analogous governing instruments, as applicable) of Buyer; or (ii) to Buyer’s knowledge, result in the violation of any law, statute, rule, regulation, judgment, order or decree
of any court or governmental agency or body, domestic or foreign, having jurisdiction over the or any of its properties or assets. 

(i)         No consent, approval, authorization, order, registration or qualification of or with any
court or arbitrator or governmental or regulatory authority is required for the execution, delivery and performance by Buyer of this Agreement, the issuance and sale by Buyer of the Shares, except for such consents, approvals, authorizations, orders
and registrations or qualifications as may be required under applicable state securities laws or the NASDAQ Capital Market in connection with the sale of the Shares. 

(j)         Buyer has taken no action designed to, or likely to have the effect of, terminating the
registration of the Common Stock under the Exchange Act or delisting the Common Stock from the NASDAQ Capital Market, nor has Buyer received any notification that the SEC or the 

  
 14 

 
NASDAQ Capital Market is contemplating terminating such registration or listing. To Buyer’s knowledge, it is in compliance with all applicable listing requirements of the NASDAQ Capital
Market. Buyer has no reason to believe that it will not in the foreseeable future continue to be in compliance with all such listing and maintenance requirements. 

(k)         The financial statements, together with the related notes and schedules, included in the
SEC Reports fairly present in all material respects the financial position and the results of operations and changes in financial position of Buyer and other consolidated entities at the respective dates or for the respective periods therein
specified. Such financial statements and related notes and schedules have been prepared in accordance with the GAAP applied on a consistent basis throughout the periods involved except as may be set forth in the related notes included in the SEC
Reports. All disclosures contained in the SEC Reports, if any, regarding “non-GAAP financial measures” (as such term is defined by the rules and regulations of the SEC) comply, in all material respects, with Regulation G of the Exchange
Act and Item 10 of Regulation S-K under the Securities Act, to the extent applicable. The financial statements, together with the related notes and schedules, included in the SEC Reports comply in all material respects with the Exchange Act,
and the Rules and Regulations and the rules and regulations under the Exchange Act. Buyer and the Subsidiaries do not have any material liabilities or obligations, direct or contingent (including any off-balance sheet obligations), not described in
the SEC Reports. 
 (l)         Mayer Hoffman McCann P.C. (the “Accountant”),
whose report on the consolidated financial statements of Buyer is filed with the SEC as part of Buyer’s most recent Annual Report on Form 10-K filed with the SEC, are and, during the periods covered by their report, were an independent
registered public accounting firm within the meaning of the Securities Act and the Public Company Accounting Oversight Board (United States). To Buyer’s knowledge, the Accountant is not in violation of the auditor independence requirements of
the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”) with respect to Buyer. 

(m)         To Buyer’s knowledge, all agreements between Buyer and third parties expressly
referenced in the SEC Reports are legal, valid and binding obligations of Buyer enforceable in accordance with their respective terms, except to the extent that (i) enforceability may be limited by bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting creditors’ rights generally and by general equitable principles and (ii) the indemnification provisions of certain agreements may be limited by federal or state securities laws or public policy
considerations in respect thereof. 
 (n)         Except as set forth in the SEC Reports, there is
no action, suit, claim or proceeding pending to which Buyer or a Subsidiary is a party or of which any property or assets of Buyer or any of its Subsidiaries is the subject which is required to be described in the SEC Reports and is not described
therein, or which, individually or in the aggregate, if determined adversely to Buyer could have a Material Adverse Effect or prevent or delay the consummation of the transactions contemplated hereby; and to the best of Buyer’s knowledge, no
such action, suit, claim or proceedings is threatened. 
 (o)         To Buyer’s knowledge,
and except as disclosed in the SEC Reports, Buyer and its Subsidiaries own, possess, license or have other rights to use all foreign and domestic patents, patent applications, trade and service marks, trade and service mark registrations, trade
names, copyrights, licenses, inventions, trade secrets, technology, Internet domain names, know-how and other intellectual property (collectively, the “Buyer IP”), necessary for the conduct of their respective businesses as now
conducted except to the extent that the failure to own, possess, license or otherwise hold adequate rights to use such Buyer IP would not, individually or in the aggregate, have a Material Adverse Effect. Except as disclosed in the SEC Reports
(i) there are no rights of third parties to any such Buyer IP owned by Buyer and its Subsidiaries; (ii) to Buyer’s knowledge, there is no infringement by third parties of any 

  
 15 

 
such Buyer IP; (iii) there is no pending or, to Buyer’s knowledge, threatened action, suit, proceeding or claim by others challenging Buyer’s and its Subsidiaries’ rights in
or to any such Buyer IP; (iv) there is no pending or, to Buyer’s knowledge, threatened action, suit, proceeding or claim by others challenging the validity or scope of any such Buyer IP, other than patent application prosecution
proceedings in the United States Patent Office, and foreign counterpart offices, with respect to pending patent applications owned or licensed by Buyer or its Subsidiaries; (v) there is no pending or, to Buyer’s knowledge, threatened
action, suit, proceeding or claim by others that Buyer or its Subsidiaries infringe or otherwise violate any patent, trademark, copyright, trade secret or other proprietary rights of others; (vi) to Buyer’s knowledge, there is no
third-party U.S. patent or published U.S. patent application which contains claims for which an Interference Proceeding (as defined in 35 U.S.C. §135) has been commenced against any patent or patent application described in the SEC Reports as
being owned by or licensed to Buyer or its Subsidiaries; and (vii) to Buyer’s knowledge, Buyer and its Subsidiaries have complied with the terms of each agreement pursuant to which Buyer IP has been licensed to Buyer or such Subsidiary,
and all such agreements are in full force and effect; except, in the case of any of the items described in clauses (i)-(vii) above, those that would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse
Effect. 
 (p)        Except as set forth in the SEC Reports, Buyer and its Subsidiaries
(i) are in compliance with any and all applicable federal, state, local and foreign laws, rules, regulations, decisions and orders relating to the protection of human health and safety, the environment or hazardous or toxic substances or
wastes, pollutants or contaminants (collectively, “Environmental Laws”); (ii) have received and are in compliance with all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct its
business as described in the SEC Reports; and (iii) have not received notice of any actual or potential liability for the investigation or remediation of any disposal or release of hazardous or toxic substances or wastes, pollutants or
contaminants, except, in the case of any of clauses (i), (ii) or (iii) above, for any such failure to comply or failure to receive required permits, licenses, other approvals or liability as would not, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect. 
 (q)        Buyer and its Subsidiaries
have, in all material respects, operated at all times and are, in all material respects, currently in compliance with all statutes, rules and regulations of the Governmental or Regulatory Authorities applicable to the ownership, testing,
development, manufacture, packaging, processing, use, distribution, storage, import, export or disposal of any product manufactured, distributed or being studied by Buyer and its Subsidiaries (“Applicable Regulatory Laws”), except
as would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect. Neither Buyer nor any of its Subsidiaries has received any written notices or correspondence or other communications from, Governmental or
Regulatory Authorities alleging or asserting material non-compliance with any Applicable Regulatory Laws. 

(r)        Buyer and its Subsidiaries have good and marketable title in fee simple to, or have valid
rights to lease or otherwise use, all items of real or personal property which are material to the business of Buyer or such Subsidiary, free and clear of all liens, encumbrances, security interests, claims and defects that do not, individually or
in the aggregate, materially affect the value of such property and do not interfere with the use made and proposed to be made of such property by Buyer and any of its Subsidiaries; and all of the leases and subleases material to the business of
Buyer and its Subsidiaries, and under which Buyer or any such Subsidiary holds properties described in the SEC Reports, are in full force and effect, and neither Buyer nor any Subsidiary has received any notice of any material claim of any sort that
has been asserted by anyone adverse to the rights of Buyer or any such Subsidiary under any of the leases or subleases mentioned above, or affecting or questioning the rights of Buyer or any such Subsidiary to the continued possession of the leased
or subleased premises under any such lease or sublease. 

  
 16 

 (s)        Each of Buyer and its Subsidiaries carries,
or is covered by, insurance provided by recognized, financially sound and reputable institutions with policies in such amounts and covering such risks as is adequate for the conduct of its business and the value of its properties and as is customary
for companies engaged in similar businesses in similar industries. Each of Buyer and its Subsidiaries has no reason to believe that it will not be able (i) to renew its existing insurance coverage as and when such policies expire or
(ii) to obtain comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that would not result in a Material Adverse Effect. Neither Buyer nor any Subsidiary has been
denied any insurance coverage that it has sought or for which it has applied. 
 (t)        Buyer
possesses all Permits which are necessary or desirable for the ownership of its properties or the conduct of its business as described in the SEC Reports except where any failures to possess or make the same, individually or in the aggregate, would
not have a Material Adverse Effect. Buyer is in compliance in all material respects with all such Permits, and all such Permits are valid and in full force and effect, except where any non-compliance or the validity or failure to be in full force
and effect would not, individually or in the aggregate, have a Material Adverse Effect. 

(u)        Each of Buyer and its Subsidiaries (i) has timely filed (or filed an extension to
file) all necessary federal, state, local and foreign tax returns, and all such filed returns were true, complete and correct, (ii) has paid all federal, state, local and foreign taxes, assessments, governmental or other charges due and payable
for which it is liable, including, without limitation, all sales and use taxes and all taxes which Buyer and any of its Subsidiaries are obligated to withhold from amounts owing to employees, creditors and third parties (including independent
contractors), and (iii) does not have any tax deficiency or claims outstanding or assessed or, to the best of its knowledge, proposed against it, except those, in each of the cases described in clauses (i), (ii) and (iii) of this
Section 7(u), that would not, individually or in the aggregate, have a Material Adverse Effect. 

(v)        Buyer has no liability or obligation of any nature (whether accrued, absolute, contingent
or otherwise), other than (i) liabilities and obligations disclosed in the SEC Reports, (ii) liabilities and obligations incurred in the ordinary course of business since the date of the last financial statements included in the SEC
Reports that would not reasonably be expected to be material to Buyer, (iii) liabilities under contracts (other than any such liability resulting from a breach or default thereunder) and (iv) liabilities and obligations incurred in
connection with this Agreement and the transactions contemplated by this Agreement. 

(w)        Neither Buyer nor any of the Subsidiaries has defaulted on any installment on indebtedness
for borrowed money or on any rental on one or more long-term leases, which defaults, individually or in the aggregate, would reasonably be expected to have a Material Adverse Effect. Buyer has not filed a report pursuant to Section 13(a) or
15(d) of the Exchange Act since the filing of its last Annual Report on Form 10-K, indicating that it has defaulted on any installment on indebtedness for borrowed money or on any rental on one or more long-term leases, which defaults,
individually or in the aggregate, would reasonably be expected to have a Material Adverse Effect. 

(x)        Neither Buyer, nor any of the Subsidiaries, nor, to Buyer’s knowledge, any of their
respective directors, officers or controlling persons has taken, directly or indirectly, any action designed, or that has constituted or might reasonably be expected to cause or result in, under the Exchange Act or otherwise, the stabilization or
manipulation of the price of any security of Buyer to facilitate the sale or resale of the Shares. 

  
 17 

 (y)         Neither Buyer nor any of the Subsidiaries or
any related entities (i) is required to register as a “broker” or “dealer” in accordance with the provisions of the Exchange Act or (ii) directly or indirectly through one or more intermediaries, controls or is a
“person associated with a member” or “associated person of a member” (within the meaning set forth in the FINRA Manual). Buyer and each of its Subsidiaries maintain systems of internal accounting controls sufficient to provide
reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with
generally accepted accounting principles and to maintain asset accountability; (iii) access to assets is permitted only in accordance with management’s general or specific authorization; and (iv) the recorded accountability for assets
is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. Buyer’s internal control over financial reporting is effective and Buyer is not aware of any material weaknesses in
its internal control over financial reporting (other than as set forth in the SEC Reports). Since the date of the latest audited financial statements of Buyer included in the SEC Reports, there has been no change in Buyer’s internal control
over financial reporting that has materially and adversely affected, or is reasonably likely to materially and adversely affect, Buyer’s internal control over financial reporting. Buyer has established disclosure controls and procedures (as
defined in Exchange Act Rules 13a-15 and 15d-15) for Buyer and designed such disclosure controls and procedures to ensure that material information relating to Buyer and each of its Subsidiaries is made known to the certifying officers by others
within those entities, particularly during the period in which Buyer’s Annual Report on Form 10-K or Quarterly Report on Form 10-Q, as the case may be, is being prepared. Buyer’s certifying officers have evaluated the effectiveness of
Buyer’s controls and procedures as of a date within 90 days prior to the filing date of the Form 10-K for the fiscal year most recently ended (such date, the “Evaluation Date”). Buyer presented in its Form 10-K for the fiscal
year most recently ended the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date and the disclosure controls and procedures are effective.
Since the Evaluation Date, there have been no significant changes in Buyer’s internal controls (as such term is defined in Item 307(b) of Regulation S-K under the Securities Act) or, to Buyer’s knowledge, in other factors that could
significantly affect Buyer’s internal controls. 
 (z)         There is and has been no
failure on the part of Buyer or, to Buyer’s knowledge, any of Buyer’s directors or officers, in their capacities as such, to comply in all material respects with any applicable provisions of the Sarbanes-Oxley Act and the rules and
regulations promulgated thereunder. Each of the principal executive officer and the principal financial officer of Buyer (or each former principal executive officer of Buyer and each former principal financial officer of Buyer as applicable) has
made all certifications required by Sections 302 and 906 of the Sarbanes-Oxley Act with respect to all reports, schedules, forms, statements and other documents required to be filed by it or furnished by it to the SEC. For purposes of the preceding
sentence, “principal executive officer” and “principal financial officer” shall have the meanings given to such terms in the Sarbanes-Oxley Act. 

(aa)        Neither Buyer nor any of the Subsidiaries has incurred any liability for any
finder’s fees, brokerage commissions or similar payments in connection with the transactions herein contemplated. 

(bb)        No labor disturbance by or dispute with employees of Buyer or any of its Subsidiaries
exists or, to the knowledge of Buyer, is threatened which would reasonably be expected to result in a Material Adverse Effect. 

(cc)        Neither Buyer nor any of the Subsidiaries is or, after giving effect to the offering and
sale of the Shares, will be an “investment company” or an entity “controlled” by an “investment company,” as such terms are defined in the Investment Company Act of 1940, as amended (the “Investment Company
Act”). 

  
 18 

 (dd)        The operations of Buyer and its Subsidiaries
are and have been conducted at all times in compliance with applicable financial record keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money laundering statutes of all jurisdictions
to which Buyer or its Subsidiaries are subject, the rules and regulations thereunder and any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Money
Laundering Laws”), except as would not reasonably be expected to result in a Material Adverse Effect; and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving Buyer or
any of its Subsidiaries with respect to the Money Laundering Laws is pending or, to the knowledge of Buyer, threatened. 

(ee)        There are no transactions, arrangements and other relationships between and/or among
Buyer, and/or, to the knowledge of Buyer, any of its affiliates and any unconsolidated entity, including, but not limited to, any structural finance, special purpose or limited purpose entity (each, an “Off Balance Sheet
Transaction”) that would reasonably be expected to affect materially Buyer’s liquidity or the availability of or requirements for its capital resources, including those Off Balance Sheet Transactions described in the SEC’s
Statement about Management’s Discussion and Analysis of Financial Conditions and Results of Operations (Release Nos. 33-8056; 34-45321; FR-61), required to be described in the SEC Reports which have not been described as required. 

(ff)        Buyer is not a party to any agreement with an agent or underwriter for any other
“at-the-market” or continuous equity transaction, except as disclosed in the Current Report on Form 8-K filed with the SEC on March 2, 2015. 

(gg)        To the knowledge of Buyer, each material employee benefit plan, within the meaning of
Section 3(3) of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), that is maintained, administered or contributed to by Buyer or any of its affiliates for employees or former employees of Buyer and any
of its Subsidiaries has been maintained in material compliance with its terms and the requirements of any applicable statutes, orders, rules and regulations, including but not limited to ERISA and the Code; no prohibited transaction, within the
meaning of Section 406 of ERISA or Section 4975 of the Code, has occurred which would result in a material liability to Buyer with respect to any such plan excluding transactions effected pursuant to a statutory or administrative
exemption; and for each such plan that is subject to the funding rules of Section 412 of the Code or Section 302 of ERISA, no “accumulated funding deficiency” as defined in Section 412 of the Code has been incurred, whether
or not waived, and the fair market value of the assets of each such plan (excluding for these purposes accrued but unpaid contributions) exceeds the present value of all benefits accrued under such plan determined using reasonable actuarial
assumptions. 
 (hh)        No forward-looking statement (within the meaning of Section 27A of
the Securities Act and Section 21E of the Exchange Act) (a “Forward-Looking Statement”) contained in the SEC Reports has been made or reaffirmed without a reasonable basis or has been disclosed other than in good faith. 

(ii)        The issuance, sale and delivery of the Shares will not violate Regulation T, U or X of
the Board of Governors of the Federal Reserve System or any other regulation of such Board of Governors. 

(jj)        (i) Neither Buyer nor, to Buyer’s knowledge, the Subsidiaries, nor to
Buyer’s knowledge, any of their respective executive officers has, in the past five years, made any unlawful contributions to any candidate for any political office (or failed fully to disclose any contribution in violation of law) or made any
contribution or other payment to any official of, or candidate for, any federal, state, municipal, or foreign office or other person charged with similar public or quasi-public duty 

  
 19 

 
in violation of any law or of the character required to be disclosed in the SEC Reports; (ii) except as described in the SEC Reports, there are no material outstanding loans or advances or
material guarantees of indebtedness by Buyer or, to Buyer’s knowledge, any Subsidiary to or for the benefit of any of their respective officers or directors or any of the members of the families of any of them; and (iii) Buyer has not
offered, or caused any placement agent to offer, Common Stock to any person with the intent to influence unlawfully (A) a customer or supplier of Buyer or any Subsidiary to alter the customer’s or supplier’s level or type of business
with Buyer or any Subsidiary or (B) a trade journalist or publication to write or publish favorable information about Buyer or any Subsidiary or any of their respective products or services, and, (iv) neither Buyer nor any Subsidiary nor,
to Buyer’s knowledge, any employee or agent of Buyer or any Subsidiary has made any payment of funds of Buyer or any Subsidiary or received or retained any funds in violation of any law, rule or regulation (including, without limitation, the
Foreign Corrupt Practices Act of 1977), which payment, receipt or retention of funds is of a character required to be disclosed in the SEC Reports. 

(kk)        Neither the execution of this Agreement, nor the issuance, offering or sale of the
Shares, nor the consummation of any of the transactions contemplated herein and therein, nor the compliance by Buyer with the terms and provisions hereof and thereof will conflict with, or will result in a breach of, any of the terms and provisions
of, or has constituted or will constitute a default under, or has resulted in or will result in the creation or imposition of any lien, charge or encumbrance upon any property or assets of Buyer pursuant to the terms of any contract or other
agreement to which Buyer may be bound or to which any of the property or assets of Buyer is subject, except (i) such conflicts, breaches or defaults as may have been waived and (ii) such conflicts, breaches and defaults that would not
reasonably be expected to have a Material Adverse Effect; nor will such action result (x) in any violation of the provisions of the organizational or governing documents of Buyer, or (y) in any material violation of the provisions of any
statute or any order, rule or regulation applicable to Buyer or of any court or of any federal, state or other regulatory authority or other government body having jurisdiction over Buyer, other than, with respect to this clause (y) only, any
violation that would not reasonably be expected to have a Material Adverse Effect. 

(ll)        (i) Buyer represents that, neither Buyer nor any of its Subsidiaries (collectively, the
“Entity”) or, to Buyer’s knowledge, any director, officer, employee, agent, affiliate or representative of the Entity, is a government, individual, or entity (in this Section 7(ll), “Person”) that is, or
is owned or controlled by a Person that is: (A) the subject of any sanctions administered or enforced by the U.S. Department of Treasury’s Office of Foreign Assets Control, the United Nations Security Council, the European Union, Her
Majesty’s Treasury, or other relevant sanctions authority (collectively, “Sanctions”), nor (B) located, organized or resident in a country or territory that is the subject of Sanctions (including, without limitation,
Burma/Myanmar, Cuba, Iran, North Korea, Sudan and Syria). (ii) The Entity represents and covenants that it will not, directly or indirectly, use the proceeds of the offering, or lend, contribute or otherwise make available such proceeds to any
subsidiary, joint venture partner or other Person (A) to fund or facilitate any activities or business of or with any Person or in any country or territory that, at the time of such funding or facilitation, is the subject of Sanctions; or
(B) in any other manner that will result in a violation of Sanctions by any Person (including any Person participating in the offering, whether as underwriter, advisor, investor or otherwise). (iii) The Entity represents and covenants
that, except as detailed in the SEC Reports, for the past 5 years, it has not knowingly engaged in, is not now knowingly engaged in, and will not knowingly engage in, any dealings or transactions with any Person, or in any country or territory, that
at the time of the dealing or transaction is or was the subject of Sanctions. 
 (mm)        Except
as disclosed in the SEC Reports, Buyer has filed with the Governmental or Regulatory Authorities all required filings, declarations, listings, registrations, reports or submissions with respect to Buyer’s products that are described in the SEC
Reports, except where the 

  
 20 

 
failure to file could not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect; all such filings, declarations, listings, registrations, reports or
submissions were in material compliance with Applicable Regulatory Laws when filed. 

(nn)        Buyer and its representatives have made all inspections and investigations relating to
the Products and the Purchased Assets deemed necessary or desirable by Buyer. Subject to the representations and warranties of Seller set forth in Article 6, Buyer acknowledges and agrees that the Purchased Assets are otherwise sold “as is,
where is” and Buyer accepts the Purchased Assets in the condition they are in. In light of such inspections and investigations, and the representations and warranties expressly made to Buyer by Seller in this Agreement and the certificates and
other documents delivered pursuant hereto, BUYER AGREES THAT THE REPRESENTATIONS AND WARRANTIES GIVEN HEREIN BY SELLER ARE IN LIEU OF, AND BUYER HEREBY EXPRESSLY WAIVES ALL RIGHTS TO, ANY IMPLIED WARRANTIES THAT MAY OTHERWISE BE APPLICABLE
BECAUSE OF THE PROVISIONS OF THE UNIFORM COMMERCIAL CODE OR ANY OTHER LAWS, INCLUDING THE WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. Any claims Buyer may have for breach of representation or warranty shall be based
solely on the representations and warranties of Seller expressly set forth in this Agreement and the certificates and other documents delivered pursuant hereto or thereto. Buyer further acknowledges and agrees that neither Seller, its Affiliate, nor
any other Person, has made any representation or warranty, express or implied, as to the accuracy or completeness of any information regarding Seller, any of the manufacture, marketing and sale of the Products or the Compounds, the Programs, the
Purchased Assets or the Assumed Liabilities not expressly set forth in this Agreement or the certificates or other documents delivered pursuant hereto or thereto, and neither Seller nor any of its Affiliates or any other Person will have, or be
subject to, any liability to Buyer or any other Person resulting from the distribution to Buyer or its representatives, or Buyer’s use of, any such information, including any information provided in the Seller Dataroom or otherwise provided to
Buyer prior to the Closing. 
 ARTICLE 8 

COVENANTS OF THE PARTIES 

8.1        Public Announcements. Neither Seller, Buyer nor any of their respective Affiliates
shall issue any press release or make any public announcement with respect to this Agreement and the transactions contemplated hereby without obtaining the prior written consent of the other Party, which consent shall not be unreasonably withheld,
except as may be required by applicable Law, including any federal or state securities Law, upon the advice of counsel and only if the disclosing Party (x) provides the non-disclosing Party with an opportunity to first review the release or
other public announcement, (y) consults with the non-disclosing Party (whether such Party is named in such publicity, news release or public announcement or not) at a reasonable time prior to its release to allow the non-disclosing Party to
comment thereon and (z) after its release, shall provide the non-disclosing Party with a copy thereof. If a Party, based on the advice of its counsel, determines that this Agreement, or any of the other Transaction Documents, must be filed with
the SEC, then such Party, prior to making any such filing, shall provide the other Party and its counsel with a redacted version of this Agreement (and any other Transaction Document) which it intends to file and any draft correspondence with the
SEC requesting the confidential treatment by the SEC of those redacted sections of the Agreement or the other Transaction Documents, and will give due consideration to any comments provided by such other Party or its counsel and use reasonable
efforts to ensure the confidential treatment by the SEC of those sections specified by such other Party or its counsel. Following the Closing, Buyer shall be entitled to make such public announcements as it deems appropriate related to Products and
Compounds; provided, that, without Seller’s prior written consent, no such announcement shall contain any reference to any Transaction Document or the terms set forth therein or Seller, its Affiliates or actions taken with respect to
Products or Compounds prior to the Closing Date other than references materially consistent with those previously approved by Seller. 

  
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 8.2             Corporate
Names. 
 Following the Closing, Buyer shall not have any rights by virtue of this Agreement or any of the transactions or agreements
contemplated hereby, whether through the transfer of any labels or packaging, or advertising, marketing, sales and promotional materials, to any Trademarks owned or used by, or relating to, Seller or any of the Affiliates of Seller or any of their
products; provided, however, that without limiting or derogating from the foregoing, Buyer may use the Compound Inventory and Product Inventory provided by Seller to Buyer under this Agreement regardless of whether such Compound Inventory or
Product Inventory includes labels containing Trademarks owned or used by, or relating to, Seller or any of the Affiliates of Seller or any of their products. 

8.3             Regulatory Matters. 

(a)         Buyer and Seller shall use their commercially reasonable efforts to complete the transfer
of the INDs included in the Purchased Assets, at Buyer’s sole cost and expense, as promptly as possible after the Closing. 

(i)         Promptly after the Closing, Seller shall send a letter to the FDA in substantially the
form set forth as Exhibit G-1 stating that the rights to the INDs included in the Purchased Assets have been transferred to Buyer, and that Buyer is the new owner of such INDs. Within five (5) Business Days after Seller has sent the
letters referenced in the preceding sentence, Buyer shall send a letter to the FDA in substantially the form set forth as Exhibit G-2 stating its commitment to assume ownership of, and all rights and obligations related to, such INDs. 

(ii)         Both parties shall provide the other party with copies of the letters sent to the FDA
associated with such IND transfers. 
 (b)         From and after the Closing, Buyer, at its sole
cost and expense, shall be solely responsible and liable for taking all actions, paying all fees and conducting all communication with the FDA or other Governmental or Regulatory Authority as required by Law in respect of any Regulatory Filing,
including preparing and filing all reports (including adverse drug experience reports) with the appropriate Governmental or Regulatory Authority. 

8.4             Adverse Experience Reports. Seller shall promptly submit to
Buyer all adverse drug experience information brought to the attention of Seller in respect of Compounds or Current Products, as well as any material events and matters concerning or affecting the safety or efficacy of Compounds or Current Products,
each as they relate to activities of Seller prior to the Closing, but which are received or as to which Seller becomes aware following the Closing. After the Closing, Buyer shall have all responsibility for required reporting of adverse experiences
for Compounds and Products, but such reporting shall not limit Seller’s obligation for any actions necessary with respect to Products distributed prior to the Closing based upon the facts and circumstances contained in such adverse drug
experience information. 
 8.5             Affiliates. Each Party hereto
shall cause its respective Affiliates to comply with the terms of this Agreement that bind Affiliates of such Party. 

8.6             Access. Seller shall use commercially reasonable efforts to
transfer to Buyer on the Closing Date the Books and Records included within the Purchased Assets, Regulatory Filings included 

  
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within the Purchased Assets and Product Data included within the Purchased Assets that are reasonably identifiable and reasonably separable from other books and records of Seller. To the extent
that Seller is unable to transfer any such Books and Records, Regulatory Filings and Product Data on the Closing Date, Seller shall use commercially reasonable efforts to deliver such Books and Records, Regulatory Filings and Product Data to Buyer
within ninety (90) days following the Closing Date; provided, however, that Seller’s obligations under this Section 8.6 shall expire on the second (2nd) anniversary of
the Closing Date. 
 Following the Closing, Buyer will preserve all books and records included within the Purchased Assets for applicable
periods of time as required by the FDA and any other applicable Governmental or Regulatory Authority and, subject to Section 10.1 hereof, make such books and records available for inspection and copying by Seller, its Affiliates or their
respective representatives, at Seller’s expense, upon reasonable request and upon reasonable notice; provided, that such books and records shall be made available only to the extent such availability is necessary for the purposes of
enabling Seller or its Affiliates to comply with its regulatory obligations or to defend claims for Excluded Liabilities. Any such access by Seller or its Affiliates shall not unreasonably interfere with the conduct of the business of Buyer. 

8.7             Covenant Not to Sue; Non-Competition. 

(a)         Seller, on behalf of itself and its Affiliates, and its and their successors and assigns
(including any successor, assigns to, or licensee (with rights to enforce) of any of the Non-Assert IP), hereby covenant not to, or to materially assist any third party to, sue, assert any claim or counterclaim against, or otherwise participate in
any Action or Proceeding against Buyer, its Affiliates, and/or its or their respective successors and assigns, direct or indirect customers, doctors, patients, licensees, service providers, distributors, wholesalers, resellers, retailers, or direct
and indirect suppliers to the extent claiming that the Exploitation of the Compounds and/or the Current Products infringes, dilutes, conflicts with, misappropriates or otherwise violates any of the Non-Assert IP, provided, that the foregoing shall
not apply to any other pharmaceutical active ingredient other than the Compounds. Seller and its Affiliates and each of its and their successors and assigns (or any successors and assigns to any of the Non-Assert IP) shall impose the foregoing
covenant not to sue on any third party to which Seller or any of its Affiliates sells, exclusively licenses, grants any right to assert, or assigns any of the Non-Assert IP. Notwithstanding anything herein to the contrary, this Section 8.7
shall not apply to any Treanda Litigation. 
 (b)         Seller and its Affiliates and each of its
and their successors and assigns covenants and agrees not to challenge (and/or participate in any challenge to) the ownership, inventorship, enforceability, scope or validity of any of the Registered Intellectual Property and/or any Patents owned by
Buyer following the Closing Date that claim priority to or issue from any of the Registered Intellectual Property to the extent claiming any of the Compounds or the Products (including any Patents listed in the FDA’s publication entitled
Approved Drug Products with Therapeutic Equivalence Evaluations with respect to the Products) in a court of competent jurisdiction or other forum (e.g., the U.S. Patent and Trademark Office or International Trade Commission),
provided, that the foregoing shall not restrict Seller and its Affiliates from (i) responding in good faith to any lawfully issued subpoena calling for Seller or an Affiliate of Seller to provide documents or testimony or otherwise
disclose information, or (ii) commencing any such challenge in response to a proceeding for infringement of any Patent (other than with respect to issued or pending claims covering a composition of matter or method of use or manufacture of a
Compound, whether alone or as the sole active ingredient in a Current Product) brought after the Effective Date by or on behalf of Buyer or any of its Affiliates or any of their licensees, successors or assigns to the extent arising out of
Exploitation of any compound or product other than a Compound or Current Product. 

  
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 (c)         Buyer hereby grants Seller the exclusive
right and option to manufacture, supply, and market an Authorized Generic of each Product. The foregoing option will be exercisable by Seller, on a Product-by-Product basis, upon written notice delivered to Buyer on a date no later than ninety
(90) days following the earlier to occur of (i) Buyer notifying Seller of its receipt of notice that a third party has filed an ANDA or a 505(b)(2) NDA and related certification pursuant to 21 U.S.C. §355(j)(2)(A)(vii)(IV) or
§355(b)(2)(A)(iv) with respect to such Product, and (ii) Buyer notifying Seller of its desire to market an Authorized Generic for such Product (such 90-day period, the “Option Election Period”). Buyer shall notify Seller
within two (2) business days of its receipt of any such notification or of making such decision to market an Authorized Generic for such Product (such notice, the “Buyer Option Notice”). In the event Seller exercises such
option for a Product, Seller and Buyer will cooperate in good faith to determine and prepare for the manufacture, supply and launch of such Authorized Generic by Seller or its Affiliates. The launch of any such Authorized Generic by Seller shall not
be earlier than the date on which Seller is permitted to launch such Authorized Generic pursuant to the contract entered into between the Parties regarding the terms of Seller’s right to manufacture, supply, and market an Authorized Generic of
such Product. In the event the Parties are unable to reach agreement on the terms of Seller’s right to manufacture, supply, and market an Authorized Generic of a Product within ninety (90) days following Seller’s notice to Buyer,
Buyer may, or permit a third party to, launch an Authorized Generic of such Product only if either (A) the overall deal value is at least twenty percent (20%) more than the overall deal value offered by Seller for such Authorized Generic
or (B) it has been more than one (1) year since Buyer provided Seller with the Buyer Option Notice. In the event Seller does not exercise the foregoing option with respect to a Product within the Option Election Period, Buyer may, or
permit a third party to, launch an Authorized Generic of such Product. Except as expressly set forth in this Section 8.7(c), neither Buyer nor any of its Affiliates shall sell, offer to sell, commercialize or otherwise market an Authorized
Generic of any Product, and will not license, authorize, permit or otherwise enable or contract with, any third party to sell, offer to sell, commercialize or otherwise market an Authorized Generic of any Product. 

(d)         For a period of four (4) years following the Closing, neither Seller nor any of its
Affiliates shall, clinically develop, seek regulatory approval for or otherwise commercialize a Competing Product anywhere in the world, or transfer or license rights to any Person to clinically develop, seek regulatory approval for or otherwise
commercialize a Competing Product. Notwithstanding the foregoing, if (i) a Business Combination occurs with respect to Seller or an Affiliate of Seller with a third party or (ii) Seller or an Affiliate of Seller acquires a third party
(including by a merger or consolidation) so that such third party becomes an Affiliate over which Seller or another Affiliate of Seller has control (as defined in Exhibit A), or (iii) Seller or an Affiliate of Seller acquires all or
substantially all of the assets of a third party (including any subsidiaries or divisions thereof) (each of (i), (ii) and (iii), a “Seller Acquisition”), and, in each case, the third party (or any of such third party’s
Affiliates or any successors or assigns of such third party or such third party’s Affiliates, other than Seller and its Affiliates as of the Seller Acquisition) already has, or the acquired assets contain, as applicable, a program that existed
prior to, or was planned prior to and is demonstrably to be implemented shortly after, the Seller Acquisition, in each case that would otherwise violate this Section 8.7(d) (a “Seller Business Program”), then such third party
(or any of such third party’s Affiliates or any successors or assigns of such third party or such third party’s Affiliates, other than Seller and its Affiliates as of the Seller Acquisition), as applicable, will be permitted to initiate,
pursue and continue such Seller Business Program after such Seller Acquisition and such initiation, pursuit and continuation will not constitute a violation of this Section 8.7(d); provided that (A) the Seller Business Program will
use separate personnel different from the personnel used by Seller on the Programs, (B) the primary purpose of the Seller Acquisition is not to obtain the Seller Business Program and (C) the Seller Business Program constitutes less than
twenty percent (20%) of the overall value of the Seller Acquisition as determined in good faith by Seller, provided, further that if any such Seller Business Program is excluded on account of the foregoing clause (B) or
(C) of this proviso, Seller will divest such putative Seller Business Program 

  
 24 

 
within twelve (12) months of the closing date of the applicable Seller Acquisition, or shut down such putative Seller Business Program within twelve (12) months of the closing date of
the applicable Seller Acquisition (which 12-month period in foregoing shut down scenario may be extended to the extent required for regulatory or other legal reasons), but shall not be required to stop working on such Seller Business Program during
such 12-month period, provided that the foregoing clause (A) will continue to apply to Seller during such 12-month period with respect to such Seller Business Program. In addition, the foregoing covenant shall not restrict Seller and its
Affiliates from Exploiting one or more Generic Equivalents that do not contain any of the Compounds or Products, alone or in combination, as an active pharmaceutical ingredient. Buyer acknowledges and agrees that nothing in this Section 8.7
shall restrict Seller from entering into one or more agreements with third parties wherein Seller (x) agrees to utilize its sales force to promote, market, offer for sale, sell, distribute and import a third party’s Competing Product,
provided, that Seller does not develop or manufacture such Competing Product at any time during the four (4) years following the Closing, or (y) is licensed or otherwise permitted to manufacture, sell, offer for sale, market, import,
distribute, or otherwise commercialize an Approved Third Party Product that is a Competing Product, provided, that Seller does not develop such Competing Product at any time during the four (4) years following the Closing other than any
development required to maintain regulatory approval for such Competing Product. Notwithstanding anything to the contrary contained in this Section 8.7(d), on a Buyer Target-by-Buyer Target basis, if Buyer provides written notice to Seller that
Buyer has ceased Exploitation of all Compounds and Products directed against a Buyer Target as required by Section 8.11, then this Section 8.7(d) shall terminate solely with respect to such Compounds and Products, and any other Competing
Product that is also directed against such Buyer Target, provided such Competing Product is not also directed against a Buyer Target that Buyer is continuing to Exploit. 

(e)         Seller and its Affiliates and each of its and their successors and assigns covenants and
agrees not to challenge by way of any judicial or administrative action in any forum, the scope, validity, or legality of any exclusive regulatory period granted by the FDA or any other Governmental or Regulatory Authority with respect to any
Product; provided, that the foregoing shall not restrict Seller and its Affiliates from commencing any such challenge to the extent arising out of Exploitation of any compound or product other than a Compound or Product. 

(f)         In the event of a breach of any provision of this Section 8.7, Buyer may, in
addition to other rights and remedies existing in its favor, apply to any court of competent jurisdiction for specific performance and injunctive relief in order to enforce or prevent any violation of such provisions. Seller recognizes that the
restrictions contained in, and the terms of, this Section 8.7 are properly required for the adequate protection of Buyer’s rights hereunder, and agrees that if any provision in this Section 8.7 is determined by any court to be
unenforceable by reason of its extending for too great a period of time or over too great a geographic area, or by reason of its being too extensive in any other respect, such covenant shall be interpreted to extend only for the longest period of
time and over the greatest geographic area, and to otherwise have the broadest application as shall be enforceable. 

8.8             Further Assurances. 

(a)             Following the Closing for a period of one (1) year, Seller
and Buyer each agree to execute and deliver such other documents, certificates, agreements and other writings and to take such other actions as may be reasonably necessary or desirable in order to consummate or implement expeditiously the
transactions contemplated by this Agreement and to vest in Buyer good and marketable title to the Purchased Assets. 

(b)             Within sixty (60) days after the Closing, Seller will host
on-site meetings over a three (3) day period, during Seller’s normal business hours and in such a manner as not to interfere unreasonably with Seller’s normal business activities, to (i) make the personnel identified in Section

  
 25 

 
8.8(b) of the Seller Disclosure Schedule who are employed by Seller or its controlled Affiliates reasonably available to Buyer, at no charge to Buyer, for the purpose of allowing Buyer to discuss
the Purchased Assets and Exploitation of the Compounds, Products and Purchased Assets and (ii) reasonably assist with the facilitation of the establishment of a relationship between Buyer and Seller’s contract counterparties relating to
the Purchased Assets, including licensors and suppliers. Following such 60-day period, Seller will reasonably respond in good faith to any requests reasonably made by Buyer for the purposes of allowing Buyer to fully understand the Purchased Assets
and how to Exploit the Compounds, Products and Purchased Assets or facilitating the establishment of relationships between Buyer and Seller’s contract counterparties relating to the Purchased Assets provided, however, that Seller’s
obligations under this Section 8.8 shall be limited to ten (10) hours per week and expire on the first (1st ) anniversary of the Closing Date. 

8.9             Tax Matters. 

(a)         Buyer and Seller agree to furnish or cause to be furnished to the other, upon request, as
promptly as practicable, such information and assistance relating to the Purchased Assets or the Programs, including access to books and records, as is reasonably necessary for the filing of all Tax Returns by Buyer or Seller, the making of any
election relating to Taxes, the preparation for any audit by any taxing authority, and the prosecution or defense of any claim, suit or proceeding relating to any Tax. Buyer and Seller shall cooperate fully with each other in the conduct of any
audit, litigation or other proceeding relating to Taxes involving the Purchased Assets, the Programs or the Allocation. Buyer and Seller further agree, upon request, to use their commercially reasonable efforts to obtain any certificate or other
document from any Governmental Authority or any other Person as may be necessary to mitigate, reduce or eliminate any Tax that could be imposed (including with respect to the transactions contemplated hereby). 

(b)         Seller shall be responsible for and shall promptly pay when due all Property Taxes levied
with respect to the Purchased Assets attributable to the Pre-Closing Tax Period and shall be entitled to any refunds of such Property Taxes attributable to the Pre-Closing Tax Period, and Buyer shall be responsible for and shall promptly pay when
due all Property Taxes levied with respect to the Purchased Assets attributable to the Post-Closing Tax Period and shall be entitled to any refunds of such Property Taxes attributable to the Post-Closing Tax Period. All Property Taxes levied with
respect to the Purchased Assets for the Straddle Period shall be apportioned between the Pre-Closing Tax Period and the Post-Closing Tax Period, as follows: the portion allocable to the Pre-Closing Tax Period shall be deemed to be the amount of such
Tax for the entire Straddle Period multiplied by a fraction the numerator of which is the number of days in such Straddle Period included in the Pre-Closing Tax Period and the denominator of which is the number of days in the entire Straddle Period;
the portion allocable to the Post-Closing Tax Period shall be deemed to be the amount of such Tax for the entire Straddle Period multiplied by a fraction the numerator of which is the number of days in such Straddle Period included in the
Post-Closing Tax Period and the denominator of which is the number of days in the entire Straddle Period. Any refund of Property Taxes with respect to the Purchased Assets for the Straddle Period shall be similarly apportioned between the
Pre-Closing Tax Period and the Post-Closing Tax Period in the manner described in the preceding sentence. Upon receipt of any bill for such Taxes relating to the Purchased Assets, Buyer, on one hand, and Seller, on the other hand, shall present a
statement to the other setting forth the amount of reimbursement to which each is entitled under this Section 8.9(b) together with such supporting evidence as is reasonably necessary to calculate the proration amount. The proration amount shall
be paid by the Party owing it to the other within ten (10) days after delivery of such statement. In the event that Buyer or Seller shall make any payment for which it is entitled to reimbursement under this Section 8.9(b), the applicable
Party shall make such reimbursement promptly but in no event later than ten (10) days after the presentation of a statement setting forth the amount of reimbursement to which the presenting Party is entitled along with such supporting evidence
as is reasonably necessary to calculate the amount of reimbursement. 

  
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 (c)         Seller shall promptly notify Buyer in
writing upon receipt by Seller of notice of any pending or threatened federal, state, local or foreign Tax audits or assessments relating to the income, properties or operations of Seller that reasonably may be expected to adversely impact
Buyer’s ownership of the Purchased Assets or the Programs. 
 (d)         At the Closing,
Seller shall deliver to Buyer such forms and certificates, duly executed and acknowledged, in form and substance reasonably satisfactory to Buyer, certifying that the transactions contemplated under this Agreement are exempt from withholding under
Section 1445 of the Code. 
 (e)         Any payments made pursuant to Section 8.9 or
Article 9 shall constitute an adjustment to the Purchase Price for Tax purposes and shall be treated as such by the parties on their Tax Returns to the extent permitted by applicable Law. 

8.10            Market Stand-Off. Seller hereby agrees that it will not for
a period ending on the earlier to occur of one (1) year after the Closing and a Buyer Fundamental Event: 

(a)         offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase
any option or contract to sell, grant any option, right or warrant to purchase, lend or otherwise transfer or dispose of any shares of Buyer Common Stock or other equity securities of Buyer whether now owned or hereafter acquired by Seller or with
respect to which Seller has or hereafter acquires the power of disposition, in each case, other than to an Affiliate of Seller; and 

(b)         purchase or otherwise acquire any additional Buyer Common Stock or other equity
securities of Buyer; provided, however, that Seller may purchase additional Buyer Common Stock or other equity securities of Buyer directly from Buyer or in future underwritten offerings conducted by Buyer. 

8.11            Reporting. After the Closing, Buyer shall prepare and
maintain, and will cause its licensees and sublicensees to prepare and maintain, reasonably complete and accurate records regarding the Development of Compounds and Products, and regulatory approvals and commercialization activities related to
Products worldwide. Until such time as Seller has sold or otherwise disposed of all of the Shares, Buyer shall provide to Seller semi-annual reports describing in reasonable detail Buyer’s efforts with respect to Exploitation, regulatory
approvals and commercialization of the Compounds, including (i) a description of material Development activities performed during such 6-month period and planned for the next 12-month period; (ii) the results of any human clinical studies;
(iii) any IND or NDA regulatory submissions or approvals made or received for Products; and (iv) a description of commercialization activities performed for the Products during such 6-month period and planned for the next 12-month period.
In addition, Buyer will reasonably respond in good faith to any requests reasonably made by Seller for additional information regarding any such activities. Without limiting the foregoing, until such time as Seller has sold or otherwise disposed of
all of the Shares, in the event that Buyer elects to cease Exploitation of all Compounds and Products directed against a Buyer Target, then Buyer shall notify Seller within thirty (30) days of making such election. 

8.12            Diligence. Beginning as of the Closing and ending at the
time when Seller has sold or otherwise disposed of all of the Shares, Buyer (itself or through one or more licensees or sublicensees) will use Commercially Reasonable Efforts to Exploit the Compounds or the Products. Buyer’s obligation to use
Commercially Reasonable Efforts to Exploit the Compounds and the Products shall include using 

  
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Commercially Reasonable Efforts to (i) Develop the Compounds and Products and obtain regulatory approvals therefor, (ii) timely prepare, file and prosecute all filings, submissions,
authorizations and approvals related to any IND or NDA for each Product with Governmental or Regulatory Authority in each major market for such Product, and (iii) commercialize the Products after obtaining regulatory approval therefor in each
major market. 
 8.13         Insurance. As of the Closing Date, the coverage under all
insurance policies of Seller and its Affiliates shall continue in force only for the benefit of Seller and its Affiliates, and not for the benefit of Buyer. As of the Closing Date, Buyer agrees to arrange its own insurance policies with respect to
the Purchased Assets and Assumed Liabilities covering all periods and agrees not to seek, through any means, to benefit from any of Seller’s or its Affiliates’ insurance policies which may provide coverage for claims relating in any way to
the Purchased Assets and Assumed Liabilities. 
 8.14         No Integration. Buyer shall
not, and shall use its commercially reasonable efforts to ensure that no Affiliate of Buyer shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act)
that will be integrated with the offer or sale of the Shares in a manner that would require the registration under the Securities Act of the sale of the Securities to Seller, or that will be integrated with the offer or sale of the Shares for
purposes of the rules and regulations of Nasdaq such that it would require stockholder approval prior to the closing of such other transaction unless stockholder approval is obtained before the closing of such subsequent transaction. 

8.15         Additional Agreements. As promptly as possible after the Closing, the Parties
shall (i) enter into a supply agreement, which shall include the terms set forth on Exhibit E hereto, (ii) use their commercially reasonable efforts, and cooperate in good faith with each other and Champions, to obtain an amendment to the
Champions Agreement to provide for (x) an agreement between Seller and Champions and (y) an agreement between Buyer and Champions relating to the CEP-40125 program and (iii) if requested by Buyer, use their commercially reasonable
efforts, and cooperate in good faith with each other, including with respect to seeking any related third party consents, to assign any Contract identified as (A) a “Post-Closing Agreement” in Section 6.6(a) of the Seller
Disclosure Schedule or (B) otherwise identified in writing by either Party after the Closing, in whole or in part (with respect to the applicable Program), and mutually agreed between the Parties in accordance with and subject to the terms of
Section 2.2 of this Agreement (as if such Contract was a Purchased Asset not sold, assigned, transferred, conveyed or delivered to Buyer at Closing). 

ARTICLE 9 

INDEMNIFICATION 

9.1             Survival of Representations, Warranties, Etc. 

  The representations and warranties made by either Party in this Agreement shall survive the Closing and shall terminate and expire
eighteen (18) months after the Closing, provided that the representations and warranties contained in Section 6.13 (Taxes) hereof shall terminate and expire sixty (60) days following the expiration of any applicable statute of
limitation, and any Liability of either Party with respect to such representations and warranties (other than for Damages attributable to fraud) shall thereupon cease; provided, however, that if, at any time prior to such expiration
date, notice of any claim for indemnification pursuant to Section 9.2(a)(i) or Section 9.2(b)(i), as the case may be, shall have been given prior to the applicable expiration date and such notice describes the circumstances with respect to
which such indemnification claim relates, such indemnification claim shall survive until such time as such claim is finally resolved. The covenants and agreements contained in this Agreement shall survive the Closing in accordance with their
respective terms, and the period during which a claim for 

  
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indemnification may be asserted in connection therewith shall survive the Closing until sixty (60) days following the expiration of any applicable statute of limitation, and any Liability of
either Party with respect to such covenant or agreement shall thereupon cease. 

9.2             Indemnification. 

(a)         By Seller. Subject to Sections 9.3 and 9.4, from and after the Closing, Seller
shall indemnify, reimburse, defend and hold harmless Buyer, its Affiliates and their respective officers, directors, employees, agents, successors and assigns (collectively, the “Buyer Indemnified Parties”) from and against any and
all costs, losses, Liabilities, damages, lawsuits, deficiencies, claims and expenses (including interest, penalties and reasonable fees and disbursements of attorneys paid in connection with the investigation, defense or settlement of any of the
foregoing) (collectively, the “Damages”) incurred by a Buyer Indemnified Party to the extent arising or resulting from: 

(i)         any inaccuracy or breach of any representation or warranty of Seller herein or in the
Intellectual Property Assignment Agreement, the Assignment and Assumption Agreement or the Bill of Sale (collectively, the “Transfer Agreements”); 

(ii)         any breach of any covenant or other agreement of Seller or any of its Affiliates herein
or in a Transfer Agreement; or 
 (iii)         the assertion by a third party against any Buyer
Indemnified Party of any Excluded Liability after the Closing. 
 (b)         By Buyer.
Subject to Sections 9.3 and 9.4, from and after the Closing, Buyer shall indemnify, reimburse, defend and hold harmless Seller, its Affiliates and their respective officers, directors, employees, agents, successors and assigns (collectively, the
“Seller Indemnified Parties”) from and against any and all Damages incurred by a Seller Indemnified Party to the extent arising or resulting from: 

(i)         any inaccuracy or breach of any representation or warranty of Buyer herein or in a
Transfer Agreement; 
 (ii)         any breach of any covenant or other agreement of Buyer herein
or in a Transfer Agreement; 
 (iii)         the assertion by a third party against any Seller
Indemnified Party of any Assumed Liability from and after the Closing; or 
 (iv)         any
action instituted against Seller in any capacity, or any of their Affiliates or any designee of Seller holding any Shares, by any stockholder of Buyer who is not an Affiliate of Seller, with respect to the sale and transfer of the Shares from Buyer
to Seller (unless such action is based upon a breach of Seller’s representations, warranties or covenants under this Agreement or any violations by Seller of state or federal securities laws). 

(c)         Procedures. The indemnified party (the “Indemnified Party”) shall
give the indemnifying party (the “Indemnifying Party”) prompt written notice (an “Indemnification Claim Notice”) (but in no event more than thirty (30) days after discovery) of any Damages or discovery of fact
upon which such Indemnified Party intends to base a request for indemnification under Section 9.2(a) or Section 9.2(b); provided, however, in no event shall the Indemnifying Party be liable for any Damages that result from
any delay in providing such notice except to the extent that the rights of the Indemnifying 

  
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Party are materially prejudiced by the failure to give notice. Each Indemnification Claim Notice must contain a reasonable description of the claim and the nature and amount of such Damages (to
the extent that the nature and amount of such Damages are known at such time). The Indemnified Party shall furnish promptly to the Indemnifying Party (but in no event more than thirty (30) days after discovery) copies of all papers and official
documents received in respect of any Damages or the related claims. All indemnification claims in respect of a Party, its Affiliates or their respective directors, officers, employees and agents (collectively, the “Indemnitees” and
each an “Indemnitee”) shall be made solely by such Party to this Agreement. 

(d)         Third Party Claims. The obligations of an Indemnifying Party under this
Section 9.2 with respect to Damages arising from claims of any third party that are subject to indemnification as provided for in Section 9.2(a) or Section 9.2(b) (a “Third Party Claim”) shall be governed by and be
contingent upon the following additional terms and conditions: 
 (i)         With respect to Third
Party Claims that involve Excluded Liabilities (in the case of Seller as the Indemnifying Party) or Assumed Liabilities (in the case of Buyer as the Indemnifying Party) or that relate to the payment of money damages, at its option, the Indemnifying
Party may assume the defense of any Third Party Claim by giving written notice to the Indemnified Party within thirty (30) days after the Indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a
Third Party Claim by the Indemnifying Party shall not be construed as an acknowledgment that the Indemnifying Party is liable to indemnify any Indemnitee in respect of the Third Party Claim, nor shall it constitute a waiver by the Indemnifying Party
of any defenses it may assert against any Indemnitee’s claim for indemnification. Failure by the Indemnifying Party to notify the Indemnified Party of its election to defend any such action within thirty (30) days after notice thereof
shall have been given to the Indemnifying Party shall be deemed a waiver by the Indemnifying Party of its right to defend such action. Upon assuming the defense of a Third Party Claim, the Indemnifying Party may appoint as lead counsel in the
defense of the Third Party Claim any legal counsel reasonably selected by the Indemnifying Party. In the event the Indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party shall promptly deliver to the Indemnifying Party
all original notices and documents (including court papers) received by any Indemnitee in connection with the Third Party Claim. Should the Indemnifying Party assume the defense of and continue to defend a Third Party Claim, except as provided in
subsection (ii) below, the Indemnifying Party shall not be liable to the Indemnified Party or any other Indemnitee for any legal expenses subsequently incurred by such Indemnified Party or other Indemnitee in connection with the analysis,
defense or settlement of the Third Party Claim. In the event that it is ultimately determined that the Indemnifying Party is not obligated to indemnify, defend or hold harmless an Indemnitee from and against the Third Party Claim, the Indemnified
Party shall reimburse the Indemnifying Party for any and all costs and expenses (including attorneys’ fees and costs of suit) and any Damages incurred by the Indemnifying Party in its defense of the Third Party Claim with respect to such
Indemnitee. 
 (ii)         Without limiting Section 9.2(d)(i), any Indemnitee shall be
entitled to participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, however, that such employment of separate legal counsel shall be at the
Indemnitee’s own expense unless (A) the employment thereof has been specifically authorized by the Indemnifying Party in writing, (B) the Indemnifying Party has failed to assume the defense and employ counsel in accordance with
Section 9.2(d)(i) (in which case the Indemnified Party shall control the defense) or (C) if the Indemnified Party and the Indemnifying Party are both named parties to the proceeding and the Indemnified Party has reasonably concluded that
there may be one or more legal defenses that are different from or in addition to those available to the Indemnifying Party (in which case the Indemnified Party shall have the right to assume the claim with respect to such defenses of such action on
behalf of the Indemnified Party). The Indemnifying Party shall not, in the defense of a claim or any 

  
 30 

 
litigation resulting therefrom, consent to entry of any judgment, except with the written consent of the Indemnified Party, or enter into any settlement except with the written consent of the
Indemnified Party, which does not include as an unconditional term thereof the giving by the claimant or the plaintiff to the Indemnified Party of a release from all liability in respect of such claim or litigation. 

(iii)         With respect to Third Party Claims for which the Indemnifying Party does not so notify
the Indemnified Party within the thirty (30) day period of its election to proceed with the control and defense of such Third Party Claim pursuant to Section 9.2(d)(ii), or if such Third Party Claim cannot be assumed by the Indemnifying
Party to Section 9.2(d)(ii) then: (i) the Indemnified Party shall diligently defend such Third Party Claim; (ii) the Indemnifying Party shall use commercially reasonable efforts to make available to the Indemnified Party any documents
and materials that are under the direct or indirect control of the Indemnifying Party or any of its Affiliates that may be necessary to the defense of such Third Party Claim (which, for the avoidance of doubt, shall not require the disclosure of
information subject to privilege or highly confidential information of such party); and (iii) the Indemnifying Party shall otherwise cooperate as reasonably requested by the Indemnified Party in the defense of such Third Party Claim. 

(iv)         With respect to any Damages relating solely to the payment of money damages in
connection with a Third Party Claim where the Indemnifying Party has assumed the defense of the Third Party Claim in accordance with Section 9.2(d)(i) and that will not result in the Indemnitee’s becoming subject to injunctive or other
relief, and as to which the Indemnifying Party shall have acknowledged in writing the obligation to indemnify the Indemnitee hereunder, the Indemnifying Party shall have the sole right to consent to the entry of any judgment, enter into any
settlement or otherwise dispose of such Damages, on such terms as the Indemnifying Party, in its sole discretion, shall deem appropriate. With respect to all other Damages in connection with Third Party Claims, where the Indemnifying Party has
assumed the defense of the Third Party Claim in accordance with Section 9.2(d)(i), the Indemnifying Party shall not have authority to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such Damages unless it
obtains the prior written consent of the Indemnified Party (which consent shall not be unreasonably withheld, conditioned or delayed). The Indemnifying Party shall not be liable for any settlement or other disposition of Damages by an Indemnitee
that is reached without the written consent of the Indemnifying Party (which consent shall not be unreasonably withheld or delayed). Regardless of whether the Indemnifying Party chooses to defend or prosecute any Third Party Claim, if an Indemnitee
shall admit any liability with respect to, or settle, compromise or discharge, any Third Party Claim without the prior written consent of the Indemnifying Party (which consent shall not be unreasonably withheld, conditioned or delayed), the
Indemnitee shall have deemed to have waived all rights to indemnification hereunder by the Indemnifying Party with the respect to such Third Party Claim. 

(v)         If the Indemnifying Party chooses to defend or prosecute any Third Party Claim, the
Indemnified Party shall, and shall cause each other Indemnitee to, cooperate in the defense or prosecution thereof and shall furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings,
hearings, trials and appeals as may be reasonably requested in connection therewith. Such cooperation shall include access during normal business hours afforded to the Indemnifying Party to, and reasonable retention by the Indemnified Party of,
records and information that are reasonably relevant to such Third Party Claim, and making Indemnitees and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided
hereunder. The Indemnifying Party shall reimburse the Indemnified Party for all its reasonable costs and expenses in connection with any of the foregoing. 

(e)         Expenses. Except as provided above, the costs and expenses, including fees and
disbursements of counsel, incurred by the Indemnified Party in connection with any claim shall be 

  
 31 

 
reimbursed on a quarterly basis by the Indemnifying Party, without prejudice to the Indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to
refund in the event the Indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 

9.3             Limitations. Notwithstanding anything to the contrary
contained in this Agreement, each of the following limitations shall apply: 
 (a)         Seller
will not be required to indemnify Buyer under Section 9.2(a)(i) except to the extent that the cumulative amount of the Damages under Section 9.2(a)(i) actually incurred by the Buyer Indemnified Parties exceeds $100,000 (the
“Deductible”) at which point Seller will be required to pay, and will have Liability for, the cumulative amount of the Damages under Section 9.2(a)(i) actually incurred by the Buyer Indemnified Parties in excess of the
Deductible; provided that this sentence shall not apply with respect to any inaccuracy or breach of any representations or warranties contained in Sections 6.5 or 6.13. 

(b)         Buyer will not be required to indemnify Seller under Section 9.2(b)(i) except to the
extent that the cumulative amount of the Damages under Section 9.2(b)(i) actually incurred by the Seller Indemnified Parties exceeds the Deductible, at which point Buyer will be required to pay, and will have Liability for, the cumulative
amount of the Damages under Section 9.2(b)(i) actually incurred by the Seller Indemnified Parties in excess of the Deductible; provided that this sentence shall not apply with respect to any claim for Damages under Section 9.2(b)(i)
that is related to representations or warranties made by Buyer regarding the sale, transfer or registration of the Shares to Seller or any of its Affiliates or designees. 

(c)         In no event shall the aggregate out-of-pocket Liability of Seller for any Damages
pursuant to Section 9.2(a)(i) exceed $1,500,000 (the “Seller R&W Cap”); provided that the Seller R&W Cap shall not apply with respect to any inaccuracy or breach of any representations or warranties contained in
Sections 6.5 or 6.13. In no event shall the aggregate out-of-pocket Liability of Seller for any Damages pursuant to Section 9.2(a) exceed $15,000,000 (the “Seller Overall Cap”); provided that the Seller Overall Cap shall
not apply with respect to (i) any breach of Section 8.7 and (ii) any Damages pursuant to Section 9.2(a)(iii). 

(d)         The amount of any Damages subject to indemnification under
Section 9.2 shall be calculated net of (x) any insurance proceeds actually received by the Indemnified Parties on account of such Damages and/or (z) any indemnification actually paid by any third party as follows: 

(i)         The Indemnified Party shall use commercially reasonable efforts to seek
full recovery under all insurance policies covering any Damage by exhausting any available remedies against insurers to the same extent as they would if such Damage were not subject to indemnification hereunder. In the event that an insurance or
other recovery is made by any Indemnified Party with respect to any Damage for which any such Person has been indemnified hereunder, then a refund equal to the aggregate amount of the recovery shall be promptly delivered to Seller. 

(ii)         The Indemnifying Party shall be subrogated to all rights of the
Indemnified Party in respect of any Damage borne by the Indemnifying Party. The Indemnified Party shall use commercially reasonable efforts to bring indemnity claims against any third party who has an indemnification obligation to either of them
with respect to any Damage and to diligently pursue such claims until finally adjudicated. 

  
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 (e)         All Damages incurred by any Buyer
Indemnified Party in respect of a breach of the representations and warranties in Section 6.13 (other than Sections 6.13(c), (d) and (f)) shall be limited to losses in respect of Taxes incurred in or attributable to the Pre-Closing Tax
Period. 
 (f)         No Party shall be entitled to indemnification under this Article 9 to the
extent Damages result from the gross negligence or intentional misconduct of the Party seeking indemnification. 

(g)         Except with respect to claims based on fraud or willful misconduct, after the Closing:

 (i)         the right of the Buyer Indemnified Parties to indemnification under this Article 9
and claims for specific performance and injunctive relief pursuant to Sections 8.7(f) and 10.1(c) shall be the exclusive remedies of the Buyer Indemnified Parties with respect to claims arising or resulting from (A) any inaccuracy or breach of
any representation or warranty of Seller or any of its Affiliates in this Agreement and the Transfer Agreements; (B) any breach of any covenant or other agreement of Seller or any of its Affiliates in this Agreement and the Transfer Agreements;
or (C) any Excluded Liability; and 
 (ii)         the right of the Seller Indemnified Parties
to indemnification under this Article 9 and claims for specific performance and injunctive relief pursuant to Section 10.1(c) shall be the exclusive remedies of the Seller Indemnified Parties with respect to claims arising or resulting from
(A) any inaccuracy or breach of any representation or warranty of Buyer in this Agreement and the Transfer Agreements; (B) any breach of any covenant or other agreement of Buyer in this Agreement and the Transfer Agreements; or
(C) any Assumed Liability. 
 (h)         Anything herein to the contrary
notwithstanding, no breach of any representation, warranty, covenant or agreement contained herein shall give rise to any right on the part of Buyer, after the consummation of the transactions contemplated hereby, to rescind this Agreement or any of
the transactions contemplated hereby. 
 (i)         Anything herein to the contrary
notwithstanding, no Buyer Indemnified Party shall be entitled to any indemnification under this Agreement with respect to any breach of any representation, warranty or covenant to the extent any Buyer Indemnified Party could have, with reasonable
efforts, mitigated or prevented the Damage with respect to such breach. Each Party and each other Indemnified Party shall take all reasonable steps to mitigate Damages for which indemnification may be claimed by them under this Agreement promptly
upon and after becoming aware of any event that could reasonably be expected to give rise to any such Damages. 

  
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 9.4             Payments.
Except for Damages pursuant to a breach of any provision of Section 8.7 or pursuant to Section 9.2(a)(iii), Seller may, at its option, elect to pay a portion or all of any Damages payable for indemnification claims to the Buyer Indemnified
Parties pursuant to this Article 9 (a) by check or wire transfer of immediately available funds and/or (b) by transferring (or having its Affiliate transfer) to Buyer a number of shares of Buyer Common Stock equal to (x) such portion
of the Damages to be paid using Buyer Common Stock divided by (y) the Buyer Stock Price calculated as of the date of such transfer. The Seller (or its Affiliate) shall promptly execute any documents reasonably required by Buyer to transfer the
shares of Buyer Common Stock to Buyer and return any original certificates representing such shares to Buyer. Payments by Seller for Damages pursuant a breach of any provision of Section 8.7 or pursuant to Section 9.2(a)(iii) shall be made
solely by check or wire transfer of immediately available funds. Notwithstanding anything to the contrary contained in this Agreement, any cash payments made pursuant to this Article 9 shall be made by check or wire transfer of immediately available
funds. 
 9.5         Consequential Damages. 

NO PARTY TO THIS AGREEMENT SHALL BE LIABLE FOR ANY PUNITIVE OR EXEMPLARY DAMAGES OR INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES (INCLUDING
LOST PROFITS OR MULTIPLES OF PROFITS OR CASH FLOWS OR SIMILAR VALUATION METHODOLOGIES), OR DIMINUTIONS IN VALUE, ARISING OUT OF OR RELATING TO THIS AGREEMENT, PROVIDED THAT THE FOREGOING SHALL NOT LIMIT THE INDEMNIFICATION OBLIGATION OF EITHER PARTY
HEREUNDER WITH RESPECT TO DAMAGES RESULTING FROM A THIRD PARTY CLAIM OR FROM A MATERIAL BREACH OF SECTION 8.7 (OTHER THAN PUNITIVE OR EXEMPLARY DAMAGES). 

ARTICLE 10 

MISCELLANEOUS 

10.1         Confidentiality. 

(a)         In addition to the restrictions set forth in Section 8.1, each Party agrees that at
and after the Closing, it shall not, without the prior written consent of the other Party, (i) disclose to any Person such other Party’s Confidential Information (as defined below), except to those of its and its Affiliates’ employees
or representatives who need to know such information for the purpose of exploiting its rights or fulfilling its obligations under this Agreement (and then only to the extent that such persons are under an obligation to maintain the confidentiality
of the Confidential Information), or (ii) use any of such other Party’s Confidential Information for any reason other than as contemplated by this Agreement. If a Party has been advised by legal counsel that disclosure of Confidential
Information of the other Party is required to be made under applicable Law (including the requirements of a national securities exchange or another similar regulatory body) or pursuant to documents subpoena, civil investigative demand,
interrogatories, requests for information, or other similar process, the Party required to disclose the Confidential Information shall (to the extent legally permitted) provide the other Party with prompt written notice of such request or demands or
other similar process so that such other Party may seek an appropriate protective order or waive the disclosing Party’s compliance with the provisions of this Section 10.1(a). In the absence of a protective order or waiver or other remedy,
the Party required to disclose the other Party’s Confidential Information may disclose only that portion of the Confidential Information that its legal counsel advises it is legally required to disclose, provided that it exercises its
commercially reasonable efforts to preserve the confidentiality of such other Party’s Confidential Information, at such other Party’s expense, including by cooperating with such other Party to obtain an appropriate protective order or
other reliable assurance that confidential treatment will be accorded the Confidential Information. 

  
 34 

 (b)         The term “Confidential
Information” as used in this Section 10.1 means (i) as to Buyer, all confidential information exclusively relating to Buyer’s business, the Programs, and the Purchased Assets and the Assumed Liabilities, and (ii) as to
Seller, all confidential information relating to the business and operations of Seller, including the Excluded Assets and the Excluded Liabilities or other obligations other than the Assumed Liabilities, but not including the Programs or Purchased
Assets, in each of (i) and (ii) whether disclosed prior to or after the date hereof. The term “Confidential Information” does not include information that (A) becomes generally available to the public other than as a result
of disclosure by the disclosing Party, (B) becomes available to the disclosing Party on a non-confidential basis from a source other than the non-disclosing Party, provided that such source is not known by the disclosing party to be
bound by a confidentiality agreement with the non-disclosing Party, or (C) was previously known by the non-disclosing Party as evidenced by the non-disclosing Party’s written records, provided that the exception provided by this subsection
(C) shall not apply in the case of Seller’s prior knowledge of information relating to the Programs, the Compounds, the Products or the Purchased Assets in existence prior to the Closing. 

(c)         In the event of a breach of any provision of this Section 10.1, Buyer or Seller may,
in addition to other rights and remedies existing in its favor, apply to any court of competent jurisdiction for specific performance and injunctive relief in order to enforce or prevent any violation of such provisions. 

10.2             Notices. All notices, requests and other communications
hereunder must be in writing and will be deemed to have been duly given only if delivered personally against written receipt or by facsimile transmission with answer back confirmation or by nationally recognized overnight courier that maintains
records of delivery to the Parties at the following addresses or facsimile numbers: 
  

			
	If to Buyer to:		 Ignyta, Inc.
 11111 Flintkote Avenue

San Diego, California 92121

			 Attention: Jonathan E. Lim, M.D.
 Facsimile:
(858) 255-5960

	
	With copies to (which shall not constitute notice):
		
			Ignyta, Inc.
			11111 Flintkote Avenue
			 San Diego, California 92121
 Attention:
Matthew W. Onaitis, Esq.
 Facsimile: (858) 255-5960

		
			Latham & Watkins LLP
			12670 High Bluff Drive
			 San Diego, CA 92130
 Attention: Cheston J.
Larson, Esq.

			Facsimile: (858) 523-5450
		
	If to Seller to:		Cephalon, Inc.
			c/o Teva Pharmaceuticals USA, Inc.
			425 Privet Road
			Horsham, PA 19044
			Attention: Legal Department
			Fax (215) 293-6499

  
 35 

			
	With a copy to (which shall not constitute notice):
		
			Goodwin Procter LLP
			53 State Street
			 Boston, MA 02109
 Attention: Kingsley L.
Taft, Esq.

			Facsimile: (617) 801-8857

 All such notices, requests and other communications will (a) if delivered personally to the address as provided in this
Section 10.2, be deemed given upon receipt, (b) if delivered by facsimile to the facsimile number as provided in this Section 10.2, be deemed given upon receipt by the sender of the answer back confirmation and (c) if delivered
by overnight courier to the address as provided in this Section 10.2, be deemed given upon receipt (in each case regardless of whether such notice, request or other communication is received by any other Person to whom a copy of such notice,
request or other communication is to be delivered pursuant to this Section 10.2). Any Party from time to time may change its address, facsimile number or other information for the purpose of notices to that Party by giving notice specifying
such change to the other Parties hereto in accordance with the terms of this Section 10.2. 

10.3         Entire Agreement. This Agreement (and all Exhibits and Schedules attached hereto
and all other documents delivered in connection herewith) supersedes all prior discussions and agreements among the Parties with respect to the subject matter hereof and contains the sole and entire agreement among the Parties hereto with respect to
the subject matter hereof. 
 10.4         Waiver. Any term or condition of this Agreement
may be waived at any time by the Party that is entitled to the benefit thereof, but no such waiver shall be effective unless set forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. No waiver by
any Party hereto of any term or condition of this Agreement, in any one or more instances, shall be deemed to be or construed as a waiver of the same or any other term or condition of this Agreement on any future occasion. 

10.5         Amendment. This Agreement may be amended, supplemented or modified only by a
written instrument duly executed by each Party hereto. 
 10.6         Third Party
Beneficiaries. Except as provided for in Article 9, the terms and provisions of this Agreement are intended solely for the benefit of each Party hereto and their respective successors or permitted assigns and it is not the intention of the
Parties to confer third-party beneficiary rights upon any other Person. 
 10.7        
Assignment; Binding Effect. Neither this Agreement nor any right, interest or obligation hereunder may be assigned by any Party hereto without the prior written consent of the other Party hereto (which consent shall not be unreasonably
withheld) and any attempt to do so will be void; provided, however, such prior written consent will not be required with respect to an assignment by either Party (a) to an Affiliate of such Party so long as such Party remains bound by
the terms hereof, or (b) in connection with a merger, sale or transfer involving all or substantially all of the assets of such Party; provided further, such prior written consent will not be required with respect to an assignment by
Buyer in connection with a merger, sale or transfer involving all or substantially all of the assets related to the Programs. This Agreement is binding upon, inures to the benefit of and is enforceable by the Parties hereto and their respective
successors and permitted assigns. 

  
 36 

 10.8             Headings. The
headings used in this Agreement have been inserted for convenience of reference only and do not define or limit the provisions hereof 

10.9             Severability. If any provision of this Agreement is held
to be illegal, invalid or unenforceable under any present or future law, and if the rights or obligations of any Party hereto under this Agreement will not be materially and adversely affected thereby, (a) such provision will be fully
severable, (b) this Agreement will be construed and enforced as if such illegal, invalid or unenforceable provision had never comprised a part hereof, (c) the remaining provisions of this Agreement will remain in full force and effect and
will not be affected by the illegal, invalid or unenforceable provision or by its severance herefrom, and (d) in lieu of such illegal, invalid or unenforceable provision, there will be added automatically as a part of this Agreement a legal,
valid and enforceable provision as similar to terms to such illegal, invalid or unenforceable provision as may be possible and reasonably acceptable to the Parties herein. 

10.10             Governing Law; Dispute Resolution. 

(a)         This Agreement shall be construed in accordance with, and governed in all respects by,
the laws of the State of Delaware (without giving effect to principles of conflicts of laws that would require the application of any other law). 

(b)         Except with respect to any claim seeking injunctive relief hereunder, in the event of any
controversy or claim arising out of, relating to or in connection with any provision of this Agreement or the rights or obligations of the Parties hereunder, the Parties will try to settle their differences amicably between themselves as
contemplated herein. To the extent not provided for herein, any Party may initiate such informal dispute resolution by sending written notice of the dispute to the other Party, and within ten (10) days after such notice, the Chief Executive
Officer (or his or her designee) of Buyer will meet with the Chief Executive Officer (or his or her designee) of Seller, for attempted resolution by good faith negotiations. If such Persons are unable to resolve such disputed matter within 30 days,
such dispute shall be finally settled by arbitration in accordance with the commercial arbitration rules of the American Arbitration Association (“AAA”), then in force, by one (1) arbitrator appointed in accordance with said
rules, provided that the appointed arbitrator shall have appropriate experience in the biopharmaceutical industry. The place of arbitration shall be New York, New York. The award rendered shall be final and binding upon all parties
participating in such arbitration. The judgment rendered by the arbitrator may, at the arbitrator’s discretion, include costs of arbitration, reasonable attorneys’ fees and reasonable costs for any expert and other witnesses. Judgment upon
the award may be entered in any court having jurisdiction, or application may be made to such court for judicial acceptance of the award and/or an order of enforcement as the case may be. The award shall be made within six months of the filing of
the demand, and the arbitrator shall agree to comply with this schedule before accepting appointment. However, this time limit may be extended by agreement of the Parties or by the arbitrator if necessary. Notwithstanding the foregoing, any Party
may seek injunctive relief or specific performance from any court of competent jurisdiction, in the event of any controversy or claim arising out of, relating to or in connection with any provision of this Agreement or the rights or obligations of
the Parties hereunder. 
 10.11             Expenses. Except as otherwise
provided in this Agreement, each Party hereto shall pay its own expenses and costs incidental to the preparation of this Agreement and to the consummation of the transactions contemplated hereby. 

10.12             Counterparts. This Agreement may be executed in any
number of counterparts and by facsimile or other electronic transmission, each of which will be deemed an original, but all of which together will constitute one and the same instrument. 

  
 37 

 10.13             Schedules,
Exhibits and Other Agreements. The Exhibits, Schedules, other agreements, certificates and notices specifically referred to herein, and delivered pursuant hereto, are an integral part of this Agreement. Any disclosure that is made in any of the
Schedules or certificates delivered pursuant to this Agreement shall be deemed responsive to any other applicable disclosure obligation hereunder where it is reasonably apparent that such disclosure is responsive to such other applicable disclosure
obligation. Certain information set forth in the Schedules is included solely for informational purposes and may not be required to be disclosed pursuant to this Agreement. The disclosure of any information shall not be deemed to constitute an
acknowledgment that such information is required to be disclosed in connection with the representations and warranties made by Buyer or Seller, as applicable, in this Agreement or that such information is material, nor shall such information be
deemed to establish a standard of materiality, nor shall it be deemed an admission of any liability of, or concession as to any defense available to, Buyer or Seller. The information contained in the Schedules is solely for purposes of this
Agreement, and no information contained herein shall be deemed to be an admission by any party hereto to any third party of any matter whatsoever, including of any obligation, violation of law, liability or breach of any agreement. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 38 

 IN WITNESS WHEREOF, this Agreement has been executed by the Parties hereto as of the date first
written above. 
  

			
	IGNYTA, INC.
		
	By:		 /s/ Jonathan E. Lim

			
	Name:		Jonathan E. Lim
	Title:		President and Chief Executive Officer
	
	CEPHALON, INC.
		
	By:		 /s/ Deborah Griffin

			
	Name:		
	Title:		
		
	By:		 /s/ Ivana Liebisch

			
	Name:		
	Title:		

  

  
 [SIGNATURE PAGE TO ASSET
PURCHASE AGREEMENT] 

 EXHIBIT A 

DEFINITIONS 

“505(b)(2) NDA” means a new drug application submitted to the FDA under 21 U.S.C. § 355(b)(2), any corresponding or
equivalent applications or submissions filed with the relevant Governmental or Regulatory Authority to obtain regulatory approval in any other country or region outside of the United States, and all amendments and supplements thereof. 

“AAA” has the meaning set forth in Section 10.10(b). 

“Action or Proceeding” means any action, suit, proceeding, arbitration, Order, hearing, assessment with respect to fines or
penalties or litigation (whether civil, criminal, administrative, investigative or informal) commenced, brought, conducted or heard by or before any Governmental or Regulatory Authority. 

“Adverse Effect” means an effect or condition that individually or in the aggregate is materially adverse to the business,
results of operations, or financial condition of the Programs, individually or taken as a whole. 
 “Affiliate” means, with
respect to any Person, any other Person that controls, is controlled by or is under common control with such Person. A Person shall be regarded as in control of another Person if it owns or controls, directly or indirectly, (i) in the case of
corporate entities at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity securities in the subject entity entitled to vote in the election of directors and, (ii) in the case of an entity that is
not a corporation, at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity securities or other ownership interests with the power to direct the management and policies of such subject entity or entitled
to elect the corresponding management authority, or such other relationship as, in fact, constitutes actual control. 

“Agreement” has the meaning set forth in the Preamble hereto. 

“Allocation” has the meaning set forth in Section 4.4(a). 

“ANDA” means an abbreviated new drug application pursuant to 21 U.S.C. § 355(j), any corresponding or equivalent
applications or submissions filed with the relevant Governmental or Regulatory Authority to obtain regulatory approval in any other country or region outside of the United States, and all amendments and supplements thereof. 

“Approved Third Party Products” means any and all pharmaceutical products that are or were sold, offered for sale, marketed,
distributed, promoted or otherwise commercialized prior to or as of the Closing Date pursuant to a NDA, ANDA, 505(b)(2) NDA or any other regulatory approval or marketing authorization (or any equivalent foreign registrations or approvals) approved
prior to or as of the Closing Date, and all amendments and supplements thereof. 
 “Assets and Properties” of any Person
means all assets and properties of any kind, nature, character and description (whether real, personal or mixed, whether tangible or intangible, whether absolute, accrued, contingent, fixed or otherwise and wherever situated), including the goodwill
related thereto, operated, owned or leased by such Person, including cash, cash equivalents, accounts and notes receivable, chattel paper, documents, instruments, general intangibles, regulatory approvals, equipment, inventory, goods and
intellectual property. 

 “Assignment and Assumption Agreement” has the meaning set forth in
Section 5.2(a)(ii). 
 “Assumed Contracts” means the Contracts or portions of the Contracts identified in
Section 6.6 of the Seller Disclosure Schedule. 
 “Assumed Liabilities” means: 

(i)         all accounts payable incurred by or on behalf of Buyer or its Affiliates with respect to
the Programs after the Closing; 
 (ii)         any and all Liabilities and obligations of Seller or
any of its Affiliates under the Assumed Contracts to be incurred after the Closing or arising from Buyer’s performance under the Assumed Contracts after the Closing, except to the extent such Liabilities and obligations, were incurred, paid,
performed or otherwise arose in full on or prior to the Closing or to the extent the same arise out of any breach or default by Seller or any of its Affiliates under the Assumed Contracts on or prior to the Closing; 

(iii)         any and all Liabilities and obligations arising out of or resulting from product
liability claims caused by the Products administered, provided or sold by or on behalf of Buyer after the Closing; and 

(iv)         except as otherwise provided herein, any and all other Liabilities and obligations that
arise out of or are related to the Purchased Assets (including the Regulatory Filings), the Programs, Compounds or Products, attributable to occurrences and circumstances arising after the Closing. 

“Astellas Agreement” means the License Agreement, dated May 1, 2003, between Astellas Deutschland GmbH and Seller, as
amended. 
 “Authorized Generic” means any drug product sold, licensed, offered for sale, or distributed under an NDA, and
marketed under a different labeler code, product code, trade name, trademark, or packaging (other than repackaging for the listed drug for use in institutions) than the brand drug for such NDA. 

“Bill of Sale” has the meaning set forth in Section 5.2(a)(iii). 

“Binding Affinity” means the biochemical measure by which a Compound binds to one or more of the Buyer Targets and is
expressed as a biochemical IC50. 
 “Books and Records” means all files, documents, instruments, papers, books and records
owned by Seller or any of its Affiliates relating exclusively to the Programs or the Purchased Assets. 
 “Business
Combination” means with respect to a Party, any of the following events: (i) any third party (or group of third parties acting in concert as a “group” within the meaning of Section 13(d) of the Exchange Act) acquires
(including by way of a tender or exchange offer or issuance by such party), directly or indirectly, beneficial ownership or a right to acquire beneficial ownership of shares of such Party representing fifty percent (50%) or more of the voting
shares (where voting refers to being entitled to vote for the election of directors) then outstanding of such Party; (ii) such Party consolidates with or merges into another corporation or entity which is a third party, or any corporation or
entity which is a third party consolidates with or merges into such Party, in either event pursuant to a transaction in which more than fifty percent (50%) of the voting shares of the acquiring or resulting entity outstanding immediately after
such consolidation or merger is not held by the holders of the outstanding voting shares of such Party immediately preceding such consolidation or merger; or (iii) such Party sells, transfers, leases or otherwise disposes of all or
substantially all of its assets to a third party. 

 “Business Day” means a day other than Saturday, Sunday or any day on which banks
located in the State of California are authorized or obligated to close. 
 “Buyer” has the meaning set forth in the
Preamble to this Agreement. 
 “Buyer Common Stock” means Buyer’s common stock, par value $0.0001 per share. 

“Buyer Disclosure Schedule” has the meaning set forth in Article 7 hereof. 

“Buyer Fundamental Event” means a Business Combination involving Buyer or its Affiliates. 

“Buyer Governmental Consents” means all consents, waivers, approvals, Orders, authorizations of, declarations or filings with
any Governmental or Regulatory Authority that are required by, or with respect to, Buyer or any of its Affiliates in connection with the execution and delivery of this Agreement and the other Transaction Documents to be executed pursuant hereto by
Buyer, the consummation by Buyer or any of its Affiliates of the transactions contemplated hereby and thereby and the performance of their respective obligations hereunder and thereunder. 

“Buyer Indemnified Parties” has the meaning set forth in Section 9.2(a). 

“Buyer Stock Price” means the average of the closing sale prices of Buyer Common Stock as quoted by the Nasdaq for the ten
(10) consecutive trading days ending with the trading day that is two (2) trading days prior to the applicable issuance or transfer date. 

“Buyer Targets” means BRAF, EGFR, RET, AXL, cMET or PKCiota. 

“Buyer Third Party Consents” means all consents, waivers, approvals, authorizations of, or notices to, any third Person
(other than a Governmental or Regulatory Authority) that are required by, or with respect to, Buyer or any of its Affiliates in connection with the execution and delivery of this Agreement by Buyer, the consummation by Buyer or any of its Affiliates
of the transactions contemplated hereby and the performance of their respective obligations hereunder. 
 “Champions” means
Champions Biotechnology, Inc. 
 “Champions Agreement” means the Research and Collaboration Agreement, dated July 30,
2013, between Teva Pharmaceutical Industries, Ltd. and Champions. 
 “Closing” has the meaning set forth in
Section 5.1. 
 “Closing Date” means the date that the Closing actually occurs as provided in Section 5.1. 

“Code” means the Internal Revenue Code of 1986, as amended. 

“Commercially Reasonable Efforts” means those reasonable, diligent, good faith efforts and resources (including use and
expenditure of resources) that a company within the bio-pharmaceutical industry at a similar stage of development as Buyer would use for a compound or product discovered or identified internally by such company with similar market and/or
commercialization prospects at a similar stage in its product life cycle, taking into account the stage of development or commercialization of the compound or product, the cost-effectiveness of efforts or resources while optimizing profitability,
the 

 
competitiveness of alternative compounds or products that are or are expected to be in the marketplace, the patent and other proprietary position of the compound or product, the profitability of
the compound or product, alternative compounds or products and other relevant commercial factors. 
 “Competing Products”
means, other than Other Bendamustine Products, (i) Compounds, (ii) Products and/or (iii) any other compounds or products that are clinically developed specifically for the treatment or prevention of one or more oncologic diseases that
have a Binding Affinity of less than 100 nanomolar for one or more of the Buyer Targets; but, excluding any such compound or product that (a) has as its most potent Binding Affinity (which Binding Affinity must be less than 100 nanomolar), a
Binding Affinity for any protein kinase that is not a Buyer Target, and (b) has a Binding Affinity for any Buyer Target that is at least 10 times weaker than such Binding Affinity for such non-Buyer Target (e.g., if IC50 for the
non-Buyer Target is 10 nanomolar, then IC50 for any Buyer Target must be 101 nanomolar or higher). 
 “Compound Inventory”
means all inventory owned as of the Closing by Seller of Compounds (excluding Compounds with no potential activity against any of the Buyer Targets). 

“Compounds” means any and all compound(s) (i) prepared for or in connection with the Programs prior to the Closing Date
as potential drug candidates directed against any of the Buyer Targets, or (ii) (y) covered as a composition of matter by a claim that was pending at any time and in any forum in a patent application within the Registered Intellectual
Property prior to or as of the Closing Date and (z) any novel (i.e., not in the prior art) compositions of matter disclosed in the Registered Intellectual Property as of the Closing Date or the Intellectual Property disclosed in the
applications and/or invention disclosures required to be provided pursuant to Section 6.7(m), in all forms, and including any salt, free acid or base, crystal, co-crystal, hydrate, anhydrous form, solvate, ester, polymorph, metabolite, isomer,
regioisomer or stereoisomer (including enantiomer and diastereoisomer), and in any dosage, form or formulation. Notwithstanding anything herein to contrary, Compounds shall not include any compound or product manufactured or marketed as an Other
Bendamustine Product other than Current Compound with CAS Registry Number 1456608-94-8 (nano-bendamustine) approved under a 505(b)(2) NDA. 

“Confidential Information” has the meaning set forth in Section 10.1(b). 

“Contract” means any and all legally binding commitments, contracts, purchase orders, leases, or other agreements, whether
written or oral related to Compounds or Products. 
 “Control” or “Controlled by” means, with respect to
any Intellectual Property, possession by a Party of the right, whether directly or indirectly, and whether by ownership, license or otherwise, to assign, restrict the use of, grant the right to use, or grant a license, sublicense or other right to
or under, such Intellectual Property as provided for herein without violating the terms of any agreement or other arrangement with, or requiring the consent of, any third party. 

“Current Compounds” means, on a Program-by-Program basis, the Compounds listed on Schedule B. 

“Current Products” means, on a Program-by-Program basis, the Products that contain any of the Current Compounds as an active
pharmaceutical ingredient. 
 “Damages” has the meaning set forth in Section 9.2(a). 

“Develop” means non-clinical, preclinical and clinical drug development activities reasonably related to the development and
submission of information to a Governmental or Regulatory Authority, 

 
including toxicology, pharmacology and other discovery and pre-clinical efforts, test method development and stability testing, manufacturing process development and improvement, process
validation, process scale-up, formulation development, delivery system development, quality assurance and quality control development, statistical analysis, clinical, pre-clinical and other studies and tests, regulatory affairs, and activities
directed to obtaining regulatory approvals. 
 “Encumbrance” means any mortgage, pledge, assessment, security interest,
deed of trust, lease, lien, levy, charge or other encumbrance, or any conditional sale or title retention agreement or other agreement to give any of the foregoing in the future. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Excluded Assets” means all Assets and Properties of Seller and its Affiliates (including Seller’s rights under this
Agreement) except the Purchased Assets. 
 “Excluded Liabilities” means (i) any and all Liabilities in respect of any
Excluded Assets, including (a) the outstanding amount of all principal, interest, fees and expenses in respect of borrowed money, capital leases, installment purchases and other indebtedness of Seller, (b) any Liability of Seller for any
Tax period, or Liability imposed on the Purchased Assets with respect to a Pre-Closing Tax Period, in respect of any Tax, including (x) any Liability of Seller for the Taxes of any other Person under Treasury Regulations Section 1.1502-6
(or any similar provision of state, local, or foreign law), as a transferee or successor, by contract, or otherwise, and (y) Seller’s portion of any Transaction Taxes, but excluding any Property Taxes to the extent that they are
specifically allocated to Buyer pursuant to Section 8.9(b), (c) any environmental Liabilities of Seller, (d) any Liabilities to directors, officers or employees of Seller or in respect of Seller employee benefit, profit sharing or
health care plans, (e) any Liabilities of Seller with respect to any Action or Proceeding pending or threatened against Seller, and (f) any Liabilities of Seller (including expenses to be borne by Seller) under this Agreement or any of the
other agreements, instruments and certificates executed in connection herewith, (ii) any Liabilities of Seller or any of its Affiliates that arise out of or are related to the Purchased Assets, the Programs or Products to the extent
attributable to occurrences and circumstances arising on or prior to the Closing, and (iii) any Liabilities of Seller to the extent arising from or relating to any action taken by Seller, or any failure on the part of Seller to take any action,
at any time after the Closing Date. 
 “Exploit,” “Exploiting” or “Exploitation” means to
formulate, research, develop, seek regulatory approval for, make, have made, use, sell, have sold, offer for sale, market, promote, import, export, display, make derivative works of, copy, distribute, perform or otherwise commercialize or dispose
of. 
 “FDA” means the United States Food and Drug Administration. 

“Fully Loaded Costs” means all costs and expenses (including material and labor costs, and a reasonable allocation of
attributable overhead (including a reasonable allocation of facilities depreciation costs)) of manufacturing, supply, analytical release and stability testing, and clinical formulation development and scale-up, and other related activities to be
performed by or on behalf of Seller under the clinical supply agreement contemplated in Section 8.15, in each case, specifically relating to the manufacture and supply of Compounds and Products, with no mark-up. For clarity, where such Compound
or Product is manufactured or supplied by a third party, Seller’s Fully Loaded Costs shall include the actual fees paid by Seller to the third party, and a reasonable allocation of attributable costs incurred by Seller in managing the
applicable third party agreement and related proposals, invoices and payments and otherwise overseeing the activities of such third party, for such manufacture or supply of such Compound or Product, with no mark-up. 

“GAAP” means generally accepted accounting principles in the United States. 

“Generic Equivalents” means a pharmaceutical product that (i) relies on the findings of safety or efficacy in any
Regulatory Filings submitted to a Governmental or Regulatory Authority for another pharmaceutical product for purposes of seeking or obtaining regulatory approval, including pursuant to an ANDA or a 505(b)(2) NDA (or any corresponding applications
or submissions filed with the relevant Governmental or Regulatory Authority to obtain regulatory approval or otherwise satisfy the requirements of any relevant Governmental or Regulatory Authority outside of the United States), in each case, for

 
which such other pharmaceutical product is the reference listed drug, (ii) is marketed as an Authorized Generic of such other pharmaceutical product; or (iii) is dispensed in a
formulary position equivalent to a generic or therapeutically equivalent version of such other pharmaceutical product. 

“Governmental or Regulatory Authority” means any court, tribunal, arbitrator, authority, agency, commission, official or
other instrumentality of the United States or other country, or any supra-national organization, state, county, city or other political subdivision thereof. 

“IND” means an Investigational New Drug Application filed with FDA pursuant to 21 C.F.R. Part 312 prior to beginning clinical
testing of a Product in human subjects and all supplements and amendments that may be filed in connection with the foregoing. 

“Indemnification Claim Notice” has the meaning set forth in Section 9.2(c). 

“Indemnified Party” has the meaning set forth in Section 9.2(c). 

“Indemnifying Party” has the meaning set forth in Section 9.2(c). 

“Indemnitee” and “Indemnitees” have the respective meanings set forth in Section 9.2(c). 

“Independent Accountant” has the meaning set forth in Section 4.4(a). 

“Intellectual Property” means any and all of the following intellectual property rights owned or Controlled by Seller as of
the Closing Date and used by Seller or its Affiliates in Exploiting the Compounds for the Programs prior to the Closing Date: all (i) Patents; (ii) Know-How; and (iii) copyrights, copyright registrations, applications therefor and
renewal rights therefor, including those items identified in Section 6.7(a) of the Seller Disclosure Schedule. 
 “Intellectual
Property Assignment Agreement” has the meaning set forth in Section 5.2(a)(i). 
 “Know-How” means the
following information owned or Controlled by Seller as of the Closing Date and used by Seller or its Affiliates in Exploiting the Compounds for the Programs prior to the Closing Date: all tangible or intangible know-how, trade secrets and inventions
(whether or not patentable), and all engineering, production and other designs, drawings, specifications, formulas, technology, software, data, analytic reference materials and methods and all confidential or proprietary chemical substances, assays
and information that relates to one or more Compounds or Products. 
 “Knowledge” means the actual knowledge after
reasonable investigation of (a) Robert McKean (CMC), Todd Spradau (IP), Mike McGraw (Regulatory), Thomas Bradford Barnes (Preclinical), Philmore Robertson (Preclinical), Diane Hershock (Clinical), with respect to Seller, and (b) Jonathan
E. Lim, M.D., Jacob Chacko, M.D., Matthew Onaitis and Jeffrey Tidwell, Ph.D., with respect to Buyer. 
 “Law” means any
federal, state or local law, statute or ordinance, or any rule, regulation, or published guidelines promulgated by any Governmental or Regulatory Authority. 

“Liability” means any liability (whether known or unknown, asserted or unasserted, absolute or contingent, accrued or
unaccrued, liquidated or unliquidated, and due or to become due). 
 “Nasdaq” means The NASDAQ Capital Market LLC. 

 “NDA” means a new drug application pursuant to 21 U.S.C. § 355(b)(1), any
corresponding or equivalent applications or submissions filed with the relevant Governmental or Regulatory Authority to obtain regulatory approval in any other country or region outside of the United States, and all amendments and supplements
thereof. 
 “Non-Assert IP” means, on a Program-by-Program basis, all claims of Patents that (i) are owned or
Controlled as of the Effective Date by Seller or any of its Affiliates (which are Affiliates of Seller as of the Closing Date), (ii) are not included in the Purchased Assets; (iii) were used by Seller or any of its Affiliates in Exploiting
the Compounds for such Program; and (iv) that cover or would be infringed by the Exploitation of Compounds or Current Products against one or more Buyer Targets, provided, that the foregoing shall not apply to any other pharmaceutical active
ingredient other than the Compounds. 
 “Order” means any writ, judgment, decree, injunction or similar order of any
Governmental or Regulatory Authority (in each such case whether preliminary or final). 
 “Other Bendamustine Products”
means products that are the subject of NDA No. 22249 or NDA No. 22303 or any equivalent foreign registrations or approvals (and all amendments and supplements to such NDAs), and all Generic Equivalents thereof, including, the bendamustine
compounds and products that are the subject of 505(b)(2) NDA No. 208194 or any equivalent foreign registrations or approvals (and all amendments and supplements to such 505(b)(2) NDA). 

“Parties” means Buyer and Seller. 

“Party” means each of Buyer and Seller. 

“Patents” means any issued patents, patent applications, provisional patent applications and all future patent applications
that claim priority to or through such issued patents, patent applications and provisional patent applications, including substitutions, divisions, continuations, continuations-in-part, reissues, renewals, extensions, utilization models,
reexaminations, patents of addition, supplementary protection certificates, inventors’ certificates, requests for continued examinations, designs and re-filings thereof, or the like, as well as any foreign equivalents thereof (including
certificates of invention and any applications therefor). 
 “Permits” has the meaning set forth in Section 6.9(a).

 “Permitted Encumbrance” means (a) Encumbrances for Taxes which are not yet due and payable or which are being
contested in good faith by appropriate proceedings and for which appropriate reserves have been established in accordance with GAAP, (b) statutory mechanics’, carriers’, workmen’s, landlords’ or other similar liens arising
or incurred in the ordinary course of business which are not yet delinquent or the validity of which are being contested in good faith by appropriate proceedings, or (c) other Encumbrances that (i) are not Encumbrances on Intellectual
Property and (ii) that are incurred in the ordinary course of business that, individually and in the aggregate, do not and would not reasonably be expected to materially detract from the value or impair the use of the property subject thereto
or make such property unmarketable. 
 “Person” means any natural person, corporation, general partnership, limited
partnership, limited liability company, proprietorship, other business organization, trust, union, association or Governmental or Regulatory Authority. 

“Post-Closing Tax Period” means (a) any Tax period beginning after the Closing Date and (b) with respect to any
Straddle Period, the portion of such period beginning after the Closing Date. 

 “Pre-Closing Tax Period” means (a) any Tax period ending on or before the
Closing Date and (b) with respect to any Straddle Period, the portion of such period ending on the Closing Date. 
 “Product
Data” means all of the following owned by Seller, to the extent either (i) included in one or more of the INDs included in the Purchased Assets with respect to a Current Compound or (ii) exclusively related to a Current Compound,
except where relied upon in the context of a 505(b)(2) NDA for an Other Bendamustine Product without a right of reference: chemistry, pharmacology, toxicology, pre-clinical, clinical, regulatory and manufacturing information and data and technology,
and all submissions and correspondence with or to any Governmental or Regulatory Authority in the Territory related to Compounds or Products, including, without limitation, (a) clinical data, results (including all tables, listings and graphs)
and reports, case report forms, and other written materials or correspondence filed with or received from a Government or Regulatory Authority as part of an IND included in the Purchased Assets or other request for a Permit, (b) for each of the
Current Compounds, the following items to the extent used exclusively to manufacture, formulate, test, package, store and stabilize the Current Compounds: (1) Current Compound and raw material specifications (including the percentages and
specifications of ingredients and any related formulae or flow diagrams), (2) standard operating procedures (such as master batch records and applicable supporting procedures) and related manufacturing, engineering and other manuals (as
applicable) for the Current Compounds, (3) copies of process validation reports, method validation reports and applicable method development reports, (4) technical storage conditions and stability assay procedures and other assay
procedures (such as characterization assays as applicable) for the Current Compounds, (5) quality control and release testing procedures; (6) batch documentation (including copies of executed batch records and disposition packages) for the
Compound Inventory and Product Inventory transferred at Closing, and (7) master batch records for the Compound Inventory and Product Inventory transferred at the Closing, in any form whatsoever, including notebooks, but only to the extent the
foregoing may be in Seller’s possession or control. 
 “Product Inventory” means all inventory owned as of the Closing
by Seller of Current Products, whether held at a location or facility of Seller (or of any other Person on behalf of Seller, including in any of Seller’s warehouses, blenders, toll manufacturers, suppliers, distributors or consignees) or in
transit to or from Seller (or any such other Person), including active pharmaceutical ingredient; provided that such Product is listed by Seller in Section 6.10 of the Seller Disclosure Schedule. 

“Products” means any pharmaceutical composition or preparation, in any dosage strength or size, and for any use, that
contains any of the Compounds as an active pharmaceutical ingredient. 
 “Programs” means the activities of research and
development conducted by or on behalf of Seller in connection with Seller’s CEP-32496, CEP-40783, CEP-40125 and TEV-44229 programs. 

“Property Taxes” means all real property Taxes, personal property Taxes and similar ad valorem Taxes. 

“Purchase Price” has the meaning set forth in Section 4.1(b). 

“Purchased Assets” means, subject to Section 2.2: (i) the Patents and Know-How listed on Schedule A(i);
(ii) Compounds and Current Products; (iii) the Assumed Contracts; (iii) the Regulatory Filings listed on Schedule A(iii); (iv) the Books and Records; (v) the Product Data; (vi) the Product Inventory listed on Schedule
A(vi); and (vii) the Compound Inventory listed on Schedule A(vii). 
 “Registered Intellectual Property” means the
issued Patents and pending applications for the Patents listed on Schedule (A)(i). 

 “Regulatory Filings” means the INDs included in the Purchased Assets and related
submissions to the FDA, licenses and marketing authorizations (and the equivalent foreign applications, submissions, registrations and approvals), in each case, owned or Controlled by Seller, including marketing approvals, pricing or reimbursement
approvals, manufacturing approvals, technical, medical, and scientific licenses, and clinical and non-clinical study authorization applications or notifications and related reports, and all amendments and supplements thereto. 

“SEC” means the United States Securities and Exchange Commission. 

“SEC Reports” means (i) Buyers’ Annual Report on Form 10-K for the year ended December 31, 2014 (the “10-K”); (ii) Buyer’s Current Reports on Form 8-K filed subsequent to December 31, 2014; (iii) Buyer’s definitive proxy statement for the 2013 annual meeting of stockholders; and
(iv) such other reports, schedules and documents filed subsequent to the filing of the 10-K by Buyer or its stockholders and available on the web site of the SEC (www.sec.gov). 

“Securities Act” means the Securities Act of 1933, as amended. 

“Seller” has the meaning set forth in the Preamble to this Agreement. 

“Seller Dataroom” means that certain dataroom hosted by RR Donnelley for which Buyer or its representatives have been
provided access prior to the Closing by Seller. 
 “Seller Disclosure Schedule” has the meaning set forth in the preamble
to Article 6 of this Agreement. 
 “Seller Governmental Consents” means all consents, waivers, approvals, Orders,
authorizations of, declarations or filings with any Governmental or Regulatory Authority that are required by, or with respect to, Seller or any of its Affiliates in connection with the execution and delivery of this Agreement and the other
Transaction Documents to be executed pursuant hereto by Seller, the consummation by Seller or any of its Affiliates of the transactions contemplated hereby and thereby and the performance of their respective obligations hereunder and thereunder.

 “Seller Indemnified Parties” has the meaning set forth in Section 9.2(b). 

“Seller Overall Cap” has the meaning set forth in Section 9.3(c). 

“Seller R&W Cap” has the meaning set forth in Section 9.3(c). 

“Seller Third Party Consents” means all consents, waivers, approvals, authorizations of, or notices to, any third Person
(other than a Governmental or Regulatory Authority), including with or from the stockholders of Seller, that are required by, or with respect to, Seller or any of its Affiliates in connection with the execution and delivery of this Agreement or the
other agreements to be executed pursuant hereto by Seller, the consummation by Seller or any of its Affiliates of the transactions contemplated hereby and the performance of their respective obligations hereunder. 

“Shares” has the meaning set forth in Section 4.1(a). 

“Straddle Period” means any Tax period beginning before or on the Closing Date and ending after the Closing Date. 

 “Tax” means (i) any net income, alternative or add-on minimum tax, gross
income, gross receipts, sales, use, ad valorem, transfer, franchise, profits, license, excise, severance, stamp, occupation, premium, property, environmental under Section 59A of the Code or windfall profit tax, custom, duty or other tax, or
other like assessment imposed by a governmental, regulatory or administrative entity or agency responsible for the imposition of any such tax (domestic or foreign), including any interest, penalty or addition thereto, whether disputed or not
“Tax Return” shall mean any return, declaration, report, claim for refund, or information returned or statement relating to Taxes, including any schedule or attachment thereto, and including any amendment thereof. 

“Territory” means the entire world. 

“Third Party Claim” has the meaning set forth in Section 9.2(d). 

“Trademarks” shall mean, collectively, trademarks, service marks, trade names, slogans, logos, trade dress or other similar
source or origin identifiers (whether statutory or common law, whether registered or unregistered), together with all (a) registrations and applications for any of the foregoing, (b) extensions or renewals thereof, (c) goodwill (if
any) connected with use thereof or symbolized thereby, (d) rights and privileges arising under applicable Law with respect to any of the foregoing and (e) all rights corresponding thereto. 

“Transaction Documents” means this Agreement, the Intellectual Property Assignment Agreement, the Assignment and Assumption
Agreement and the Bill of Sale. 
 “Transaction Taxes” has the meaning set forth in Section 4.3. 

“Transfer Agreements” has the meaning set forth in Section 9.2(a)(i). 

“Treanda Litigation” means Seller’s litigation related to the Other Bendamustine Products currently pending in the
United States District Court for the District of Delaware, and such other actions which have been, are expected to be, or will be consolidated with Cephalon’s other related bendamustine cases, and all other actions brought by Seller or its
Affiliates with respect to any Other Bendamustine Products other than with respect to a 505(b)(2) NDA for the Current Compound #(nana-bendamustine). 

“Treasury Regulation” means any regulation promulgated by the U.S. Department of the Treasury under the Code.EX-10.2

 Exhibit 10.2 

REGISTRATION RIGHTS AGREEMENT 

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made and entered into as of March 17,
2015, by and among Ignyta, Inc., a Delaware corporation (the “Company”), and Cephalon, Inc., a Delaware corporation (the “Stockholder”). Each of the Company and the Stockholder may be referred to in
this Agreement as a “Party,” and, collectively, as the “Parties.” Capitalized terms used but not otherwise defined herein have the meanings assigned such terms in Section 11 of this
Agreement. 
 A.        The Company and the Stockholder are parties to that certain
Subscription Agreement, dated as of March 17, 2015 (the “Subscription Agreement”), pursuant to which the Stockholder is purchasing an aggregate of 1,500,000 shares of Common Stock of the Company, $0.0001 par value per
share (the “Subscription Shares”). 
 B.        The Company
and the Stockholder are parties to that certain Asset Purchase Agreement, dated as of March 17, 2015 (the “Asset Purchase Agreement” and, together with the Subscription Agreement, the “Purchase
Agreements”), pursuant to which the Stockholder is purchasing an aggregate of 1,500,000 shares of Common Stock of the Company, $0.0001 par value per share (the “Private Placement Shares” and, together with the
Subscription Shares, the “Shares”). 
 C.        In
connection with the transactions contemplated by the Purchase Agreements, and pursuant to the terms of the Purchase Agreements, the Parties desire to enter into this Agreement in order to grant to the Stockholder and certain of its permitted
transferees certain registration rights covering the Shares, all in accordance with the terms and conditions set forth below. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the Company and the Stockholder hereby agree as follows: 

1.        Shelf Registration. So long as any Registrable Securities are
outstanding, the Company shall take the following actions: 
 (a)        On or
prior to the Filing Date, the Company shall use its best efforts to file with the Securities and Exchange Commission, and thereafter use its best efforts to cause to be declared effective as soon as practicable, but in any event on or prior to the
Effectiveness Date, an initial registration statement on an appropriate form under the Securities Act relating to the offer and sale of the Registrable Securities by the Holders thereof (the “Registration Statement”) from
time to time in accordance with the methods of distribution (which shall include the ability to conduct an underwritten offering) set forth in the Registration Statement and Rule 415 under the Securities Act (hereinafter, the “Shelf
Registration”). Without the prior written consent of the Majority-in-Interest, no Registration Statement relating to the offer and sale of Registrable Securities shall register any transaction in any securities of the Company, other
than the offer and sale of Registrable Securities by the Holders thereof. Notwithstanding the foregoing, if for any reason the Securities and Exchange Commission does not permit the Company to include any or all of the Registrable Securities in the
initial Registration Statement 

 
due to limitations on the use of Rule 415 of the Securities Act for the resale of the Registrable Securities by the Holders, and/or the Securities and Exchange Commission informs the Company that
certain of the selling stockholders would be deemed to be statutory underwriters, the Company agrees to use its best efforts to promptly file amendments to the initial Registration Statement as required by the Securities and Exchange Commission
and/or withdraw the initial Registration Statement and file a new registration statement on Form S-1 or such other form available for registration of the Registrable Securities as a secondary offering (the “Long-Form Registration”),
in either case covering the maximum number of Registrable Securities permitted to be registered by the Securities and Exchange Commission and avoid the selling stockholders being deemed to be statutory underwriters; provided, however, that prior to
such amendment or subsequent Registration Statement, the Company shall be obligated to use its best efforts to advocate with the Securities and Exchange Commission for the registration of all of the Registrable Securities and against the selling
stockholders being deemed statutory underwriters in accordance with Commission Guidance, including without limitation, the Compliance and Disclosure Interpretations, “Securities Act Rules” No. 612.09, and the Securities Act. In the
event the Company amends the initial Registration Statement or files a subsequent Registration Statement, as the case may be, the Company will use its best efforts to file with the Securities and Exchange Commission, as promptly as allowed by the
Securities and Exchange Commission, Commission Guidance or the Securities Act, on one or more registration statements, those Registrable Securities not included in the initial Registration Statement as amended or the subsequent Registration
Statement. The number of Registrable Securities that may be included in each such registration statement shall be allocated among the Holders thereof in proportion (as nearly as practicable) to the number of Registrable Securities owned by each
Holder or in such other proportion as is necessary to avoid the selling stockholders being deemed to be statutory underwriters, which reductions shall be applied to the Holders on a pro rata basis based on the total number of Registrable Securities
held by such Holders. Notwithstanding anything herein to the contrary, if the Securities and Exchange Commission, by written comment, limits the Company’s ability to file, or prohibits or delays the filing of, a Registration Statement with
respect to any or all the Registrable Securities which were not included in the initial Registration Statement (a “Subsequent Shelf Limitation”), the Company’s compliance with such limitation, prohibition or delay solely
to the extent of such limitation, prohibition or delay shall not be a breach or default by the Company under this Agreement and shall not be deemed a failure by the Company to use “best efforts” as set forth above or elsewhere in this
Agreement. Unless otherwise specifically stated herein, the term “Registration Statement” shall refer individually to the initial Registration Statement and to each subsequent Registration Statement, if any. 

(b)         The Company shall use its best efforts to keep the Registration Statement
continuously effective under the Securities Act until such time as all of the Registrable Securities covered by the Registration Statement have been sold thereunder or pursuant to Rule 144 or may be sold without restriction pursuant to Rule 144
including, without limitation, volume limitations and other restrictions of Rule 144 (the “Shelf Registration Period”); provided, however, that the requirement of continuous effectiveness may be waived with the consent of the
Holders of the Majority-in-Interest. The Company shall be deemed not to have used its best efforts to keep the Registration Statement effective during the Shelf Registration Period if it voluntarily takes, or fails to take, any action that would
directly result in Holders of Registrable Securities covered thereby not being able to offer and sell such Registrable Securities during such period, unless such action is required by applicable law or except as provided in Section 3(a)(xii).

  
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 (c)        Notwithstanding any other
provisions of this Agreement to the contrary, the Company shall cause (i) the Registration Statement (as of the effective date of the Registration Statement), any amendment thereof (as of the effective date thereof) or supplement thereto (as of
its date), (A) to comply in all material respects with the applicable requirements of the Securities Act and the rules and regulations of the Securities and Exchange Commission and (B) not to contain any untrue statement of a material fact
or omit to state a material fact required to be stated therein or necessary in order to make the statements therein not misleading, and (ii) any related prospectus, preliminary prospectus or Free Writing Prospectus and any amendment thereof or
supplement thereto, as of its date, (A) to comply in all material respects with the applicable requirements of the Securities Act and the rules and regulations of the Securities and Exchange Commission and (B) not to contain any untrue
statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading; provided, however, the
Company shall have no such obligations or liabilities with respect to any written information pertaining to any Holder and furnished to the Company by or on behalf of such Holder specifically for inclusion therein. 

(d)        The Company shall use its best efforts to cause the Registrable Securities
included in the Registration Statement, pursuant to applicable listing requirements, to be listed on a National Securities Exchange as soon as practicable after the Registration Statement is declared effective by the Securities and Exchange
Commission. 
 2.        Demand Registration. 

(a)        Priority on Demand Registration. If (i) a Registration
Statement has not been filed with the Securities and Exchange Commission on or prior to the Filing Date, (ii) the Registration Statement has not been declared effective by the Securities and Exchange Commission by the Effectiveness Date, or
(iii) after the Registration Statement is declared effective by the SEC, it is suspended by the Company or ceases to remain continuously effective as to all Registrable Securities for which it is required to be effective, other than, in each
case, within the time period(s) permitted by Section 3(g), a Majority-in-Interest of the Registrable Securities shall have the right to request that a Demand Registration be effected as an underwritten offering,by delivering to the
Company a notice setting forth such request and the number of Registrable Securities sought to be disposed of by the Holders in such underwritten offering. All Holders proposing to participate in an underwriting shall (i) enter into an
underwriting agreement in customary form with the underwriter(s) selected for such underwriting by a Majority-in-Interest of the Registrable Securities included in such offering, which underwriter(s) shall be reasonably acceptable to the Company,
provided that, with respect to such underwriting agreement or any other documents reasonably required under such agreement, (A) no Holder shall be required to make any representation or warranty with respect to or on behalf of the Company or
any other stockholder of the Company and (B) the liability of any Holder shall be limited as provided in Section 7(b) hereof, and (ii) complete and execute all questionnaires, powers-of-attorney, indemnities, opinions and other
documents required under the terms of such underwriting agreement. If the managing underwriter(s) for an underwritten 

  
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offering advise(s) the Company and the Holders in writing that the dollar amount or number of Registrable Securities which the Holders desire to sell, taken together with all other Common Stock
or other securities which the Company desires to sell and the Common Stock or other securities, if any, as to which registration has been requested pursuant to written contractual piggyback registration rights held by other stockholders of the
Company, if any, who desire to sell or otherwise, exceeds the maximum dollar amount or maximum number of securities that can be sold in such offering without adversely affecting the proposed offering price, the timing, the distribution method, or
the probability of success of such offering (such maximum dollar amount or maximum number of securities, as applicable, the “Maximum Threshold”), then the Company shall include in such
registration: (1) first, the Registrable Securities (pro rata in accordance with the number of Registrable Securities which such Holders have requested be included in such underwritten offering, regardless of the number of
Registrable Securities or other securities held by each such Person) that can be sold without exceeding the Maximum Threshold; (2) second, to the extent that the Maximum Threshold has not been reached under the foregoing clause (1),
the Common Stock or other securities that the Company desires to sell that can be sold without exceeding the Maximum Threshold; (3) third, to the extent that the Maximum Threshold has not been reached under the foregoing clauses
(1) and (2), the Common Stock or other securities for the account of other Persons that the Company is obligated to register pursuant to written contractual arrangements, if any, with such Persons and that can be sold without exceeding the
Maximum Threshold; and (4) fourth, to the extent that the Maximum Threshold has not been reached under the foregoing clauses (1), (2) and (3), the Common Stock that other stockholders desire to sell that can be sold without
exceeding the Maximum Threshold to the extent that the Company, in its sole discretion, wishes to permit such sales pursuant to this clause (4). 

A request for an underwritten offering may be withdrawn by Holders of a majority of the Registrable Securities proposed to be
included in such offering prior to the consummation thereof, and, in such event, such withdrawal shall not be treated as a request for an underwritten offering which shall have been effected pursuant to the immediately preceding paragraph. In no
event will a Demand Registration count as the Demand Registration unless at least fifty percent (50%) of all Registrable Securities requested to be registered in such Demand Registration by the Holders initiating such Demand Registration are,
in fact, registered and sold in such registration. 
 (b)         The Company shall
not be obligated to effect more than three (3) Demand Registrations (including any underwritten offering). 

(c)         Notwithstanding any other provision of this Agreement, if any Commission
Guidance sets forth a limitation of the number of Registrable Securities to be registered on a the Registration Statement pursuant to a Demand Registration (notwithstanding the Company’s best efforts to advocate with the Securities and Exchange
Commission for the registration of all or a greater number of Registrable Securities), then, unless otherwise directed in writing by a Holder as to its Registrable Securities, the amount of Registrable Securities to be registered on such
Registration Statement will be reduced pro rata among the Holders based on the total number of unregistered Registrable Securities held by such Holders. 

  
 - 4 - 

 3.        Registration Procedures;
Removal of Legends. 
 (a)        Whenever any Registrable Securities are
registered pursuant to a Shelf Registration or the Holder has requested a Demand Registration pursuant to Section 2 of this Agreement, the Company shall use best efforts to effect the registration and the sale of such Registrable
Securities in accordance with the Holder’s intended method of disposition thereof, and pursuant thereto the Company shall as expeditiously as possible: 

(i)        respond to written comments received from the Securities
and Exchange Commission upon a review of any Registration Statement in a timely manner; 

(ii)        promptly notify each Holder of the effectiveness of the
Registration Statement filed hereunder; by 9:30 a.m. (New York time) on the second Business Day following such effectiveness, and prepare and file with the Securities and Exchange Commission such amendments and supplements to the Registration
Statement and the prospectus used in connection therewith, and otherwise take such actions, as may be necessary to keep the Registration Statement effective until the earlier of (A) the Shelf Registration Period, and (B) the date on which
all of such Registrable Securities have been disposed of by each Holder, and comply with the provisions of the Securities Act with respect to the disposition of all securities covered by the Registration Statement during such period in accordance
with the intended methods of disposition by the sellers thereof set forth in the Registration Statement; 

(iii)        promptly furnish to each Holder such number of copies of
the Registration Statement, each amendment and supplement thereto, the prospectus included in the Registration Statement (including the preliminary prospectus) and such other documents as the Holders may reasonably request in order to facilitate the
disposition of the Registrable Securities owned by each Holder; 

(iv)        if applicable, use best efforts to register or qualify
the shares covered by the Registration Statement under such other securities or blue sky laws of such jurisdictions as each Holder shall reasonably request and do any and all other acts and things which may be reasonably necessary or advisable to
enable each Holder to consummate the disposition in such jurisdictions of the Registrable Securities owned by such Holder (provided that the Company shall not be required to (A) qualify generally to do business in any jurisdiction where it
would not otherwise be required to qualify but for this subparagraph, (B) subject itself to taxation in any such jurisdiction or (C) consent to general service of process in any such jurisdiction); 

(v)        notify each Holder at any time when a prospectus relating
thereto is required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus included in the Registration Statement contains an untrue statement of a material fact or omits any fact necessary to
make the statements therein not misleading, and, as expeditiously as possible following the happening of such event, prepare a supplement or amendment to such prospectus so that, as thereafter delivered to the purchasers of such Registrable
Securities, such prospectus shall not contain an untrue statement of a material fact or omit to state any fact necessary to make the statements therein not misleading; 

  
 - 5 - 

 (vi)        without
limiting any obligations of the Company under the Purchase Agreement, use its best efforts to (x) cause all such Registrable Securities to be listed on each securities exchange on which similar securities issued by the Company are then listed,
if any, if the listing of such Registrable Securities is then permitted under the rules of such exchange or (y) if such listing is not then permitted, or no similar securities issued by the Company are then so listed, secure a designation and
quotation of all of the Registrable Securities covered by the Registration Statement on the OTC Bulletin Board; 

(vii)        provide a transfer agent and registrar for all such
Registrable Securities not later than the effective date of the Registration Statement; 

(viii)        enter into such customary agreements (including
underwriting agreements in customary form) and take all such other actions as the Holders or the underwriters, if any, reasonably request in order to expedite or facilitate the disposition of such Registrable Securities (including effecting a stock
split or a combination of shares); 

(ix)        (A) authorize the removal of any legend indicating
that such Shares have not been registered under the Securities Act and any other legend not required by applicable law from such Shares and (B) cause its transfer agent to issue such Shares without such legends to the holders thereof by
electronic delivery at the applicable balance account at the Depository Trust Company (“DTC”) upon surrender of any stock certificates evidencing such Shares; 

(x)        make available for inspection by any underwriter
participating in any disposition pursuant to the Registration Statement and any attorney, accountant or other agent retained by any such seller or underwriter, all financial and other records, pertinent corporate documents and properties of the
Company, and cause the Company’s officers, directors, employees and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or agent in connection with the Registration
Statement; 
 (xi)        otherwise use best efforts to comply with
all applicable rules and regulations of the Securities and Exchange Commission, and make available to its security holders, as soon as reasonably practicable, an earnings statement covering the period of at least twelve (12) months beginning
with the first day of the Company’s first full calendar quarter after the effective date of the Registration Statement, which earnings statement shall satisfy the provisions of Section 11(a) of the Securities Act and Rule 158 thereunder,
and which requirement will be deemed satisfied if the Company timely files complete and accurate information on Forms 10-Q and 10-K and Current Reports on Form 8-K under the Exchange Act and otherwise complies with Rule 158 under the Securities Act;

  
 - 6 - 

 (xii)    in the event of the issuance of any
stop order suspending the effectiveness of a Registration Statement, or of any order suspending or preventing the use of any related prospectus or suspending the qualification of any Common Stock included in the Registration Statement for sale in
any jurisdiction, the Company shall promptly notify each Holder and use best efforts promptly to obtain the withdrawal of such order; 

(xiii)    use best efforts to cause such Registrable Securities covered by the
Registration Statement to be registered with or approved by such other governmental agencies or authorities as may be necessary to enable the Holders thereof to consummate the disposition of such Registrable Securities; 

(xiv)    permit any Holder who, in the reasonable judgment of the Company upon the advice
of counsel, might be deemed to be an underwriter or controlling person of the Company, and, if applicable, any underwriter, a cold comfort letter from the Company’s independent public accountants in customary form and covering such matters of
the type customarily covered by cold comfort letters as the Holders of a majority of the Registrable Securities being sold reasonably request (provided that such Registrable Securities constitute at least ten percent (10%) of the securities
covered by such Registration Statement); and 
 (xv)    cooperate with each Holder and
any broker or dealer through which any such Holder proposes to sell its Registrable Securities in effecting a filing with FINRA pursuant to FINRA Rule 5110 as requested by such Holder. 

(b)        With respect to any Shares for which restrictive legends are removed
pursuant to Section 3(a)(ix), the holder thereof agrees to only sell such Shares when and as permitted by the effective Registration Statement covering such resale and in accordance with applicable securities laws and regulations. Any
fees (with respect to the Company’s transfer agent, counsel or otherwise) associated with the removal of such legend(s) shall be borne by the Company. 

(c)        The Stockholder may request that the Company remove, and the Company
agrees to authorize the removal of any legend from the Shares (i) following any sale of the Shares pursuant to Rule 144, or (ii) if such Shares are eligible for sale under Rule 144 following the expiration of the one-year holding
requirement under subparagraphs (b)(1)(i) and (d) thereof. Following the time a legend is no longer required for the Shares under this Section 3(c), the Company will, no later than three (3) Business Days following the delivery
by the Stockholder to the Company or the Company’s transfer agent of a legended certificate representing such securities, (A) deliver or cause to be delivered to the Stockholder a certificate representing such securities that is free from
all restrictive and other legends or (B) at the request of the Stockholder, cause its transfer agent to issue such Shares without such legends to the holders thereof by electronic delivery at the applicable balance account at the DTC.
Certificates for the Shares subject to legend removal hereunder may be transmitted by the Company’s transfer agent to the Stockholder by crediting the account of the Stockholder’s prime broker with DTC as directed by the Stockholder. 

(d)        If the Company fails for any reason or for no reason to issue to the
Stockholder unlegended certificates within three (3) Business Days after receipt of all documents 

  
 - 7 - 

 
necessary for the removal of the legend pursuant to Section 3(a)(ix) or Section 3(c), as applicable, (the “Deadline Date”), then, in addition to
all other remedies available to the Stockholder, if on or after the Business Day immediately following such three (3) Business Day period, the Stockholder purchases (in an open market transaction or otherwise) shares of Common Stock to deliver
in satisfaction of a sale by the holder of shares of Common Stock that the Stockholder anticipated receiving from the Company without any restrictive legend (a “Buy-In”), then the Company shall, within two (2) Business
Days after the Stockholder’s request and in the Stockholder’s sole discretion, either (i) pay cash to the Stockholder in an amount equal to the Stockholder’s total purchase price (including brokerage commissions, if any) for the
shares of Common Stock so purchased (the “Buy-In Price”), at which point the Company’s obligation to deliver such certificate (and to issue such shares of Common Stock) shall terminate, or (ii) promptly honor its
obligation to deliver to the Stockholder a certificate or certificates representing such shares of Common Stock and pay cash to the Stockholder in an amount equal to the excess (if any) of the Buy-In Price over the product of (a) such number of
shares of Common Stock, times (b) the closing bid price of the Common Stock as reported on NASDAQ Capital Market on the Deadline Date. 

(e)        Each Holder that requested that any Registrable Securities be registered
pursuant to this Agreement shall deliver to the Company such requisite information with respect to itself and its Registrable Securities as the Company may reasonably request for inclusion in the Registration Statement (and the prospectus included
therein) as is necessary to comply with all applicable rules and regulations of the Securities and Exchange Commission, and that it will promptly notify the Company of any material changes in the information set forth in the Registration Statement
furnished by or regarding the Holder or its plan of distribution. 
 (f)        The
Holders shall not effect sales of the shares covered by the Registration Statement (i) prior to the withdrawal of any stop order suspending the effectiveness of the Registration Statement, or of any order suspending or preventing the use of any
related prospectus or suspending the registration or qualification of any Registrable Securities included in the Registration Statement for sale in any jurisdiction where such shares had previously been registered or qualified or (ii) after
receipt of facsimile or other written notice from the Company instructing such Holders to suspend sales to permit the Company to correct or update the Registration Statement or prospectus until such Holder receives copies of a supplemented or
amended prospectus that corrects the misstatement(s) or omission(s) referred to above and receives notice that any required post-effective amendment has become effective. Such Holder agrees that it will immediately discontinue offers and sales of
Registrable Securities under the Registration Statement until such Holder receives copies of a supplemented or amended prospectus that corrects the misstatement(s) or omission(s) referred to above and receives notice that any post-effective
amendment has become effective. 
 (g)        Notwithstanding anything herein to
the contrary, the Company shall have the right to suspend the use of a Registration Statement for a period of not greater than forty-five (45) consecutive days and for not more than ninety (90) days in any twelve (12) month period
(“Blackout Period”), if, in the good faith opinion of the Board of Directors of the Company, after consultation with counsel, material, nonpublic information exists, including without limitation the proposed acquisition or
divestiture of assets by the Company, a strategic alliance or a financing transaction involving the Company or the existence of pending material corporate 

  
 - 8 - 

 
developments, the public disclosure of which would be necessary to cause the Registration Statement to be materially true and to contain no material misstatements or omissions, and in each such
case, where, in the good faith opinion of the Board of Directors, such disclosure would be reasonably likely to have a Material Adverse Effect (as defined in the Securities Purchase Agreement) on the Company or on the proposed transaction. The
Company must give the Holders notice promptly upon knowledge that a Blackout Period (without indicating the nature of such Blackout Period) may occur and prompt written notice if a Blackout Period will occur and such notices must be acknowledged in
writing by the Investors. Upon the conclusion of a Blackout Period the Company shall provide the Holder written notice that the Registration Statement is again available for use. 

4.        Registration Expenses. All expenses (other than Selling Expenses)
incident to the Company’s performance of or compliance with this Agreement, including without limitation all registration and filing fees, fees and expenses of compliance with securities or blue sky laws, printing expenses, messenger and
delivery expenses, fees and disbursements of custodians, and fees and disbursements of counsel for the Company and independent certified public accountants, underwriters (excluding fees, discounts and commissions) and other persons retained by the
Company(all such expenses being herein called “Registration Expenses”), shall be borne by the Company. The Company shall not be liable for any Selling Expenses. As used herein, the term “Selling
Expenses” shall mean, collectively, any selling commissions, discounts or brokerage fees. Selling Expenses shall be borne by the respective seller thereof, in proportion to the respective number of shares of Registrable Securities sold
by each of them. For the avoidance of doubt, all fees and disbursements of counsel for any Holder shall be borne by the Holders. 

5.        Holder’s Obligations. Each Holder covenants and agrees that, in
the event the Company informs such Holder in writing that it does not satisfy the conditions specified in Rule 172 and, as a result thereof, such seller is required to deliver a prospectus in connection with any disposition of Registrable
Securities, it will comply with the prospectus delivery requirements of the Securities Act as applicable to it (unless an exemption therefrom is available) in connection with sales of Registrable Securities pursuant to the Registration Statement,
and shall sell the Registrable Securities only in accordance with a method of distribution described in the Registration Statement. Each Holder has furnished to the Company all information required to be disclosed under Item 507 of Regulation
S-K under the Securities Act. 
 6.        Liquidated Damages. The Company
further agrees that, in the event that (i) a Registration Statement has not been filed with the Securities and Exchange Commission on or prior to the Filing Date, (ii) the Registration Statement has not been declared effective by the
Securities and Exchange Commission by the Effectiveness Date, or (iii) after the Registration Statement is declared effective by the SEC, it is suspended by the Company or ceases to remain continuously effective as to all Registrable Securities
for which it is required to be effective, other than, in each case, within the time period(s) permitted by Section 3(g) (each such event referred to in clauses (i), (ii) and (iii), a “Registration
Default”), for all or part of any thirty-day period (a “Penalty Period”) during which the Registration Default remains uncured (which initial thirty-day period shall
commence on the second Business Day after the date of the Registration Default if the Registration Default has not been cured by such date), the Company shall pay to each Holder 1% of such Holder’s aggregate Purchase Price of its, his or her
Shares, 

  
 - 9 - 

 
that remain Registrable Securities for which the Registration Statement is required to be effective and for which there is not otherwise an effective Registration Statement at such time, for each
Penalty Period during which the Registration Default remains uncured; provided, however, that if a Holder fails to provide the Company with any information requested by the Company that is required to be provided in the Registration Statement
with respect to such Holder as set forth herein, then the commencement of the Penalty Period described above with respect to such Holder shall be extended until two (2) Business Days following the date of receipt by the Company of such required
information from such Holder; and provided, further, that in no event shall the Company be required hereunder to pay to any Holder pursuant to this Agreement more than 1% of such Holder’s aggregate Purchase Price of all of its, his or
her Securities for which a Registration Statement is required to be effective in any Penalty Period and in no event shall the Company be required hereunder to pay to any Holder pursuant to this Agreement an aggregate amount that exceeds 10% of the
aggregate Purchase Price paid by such Holder for such Holder’s Shares. For purposes of clarification, and solely for purposes of calculating the liquidated damages pursuant to this Section 6, each Holder’s “Purchase
Price” for each Share shall be deemed to be the $10 per share (as adjusted for any subsequent stock split, stock dividend or similar event effected with respect to the Shares). The Company shall deliver said cash payment to the Holder
by the fifth Business Day after the end of such Penalty Period. If the Company fails to pay said cash payment to any Holder in full by the fifth Business Day after the end of such Penalty Period, the Company will pay interest thereon at a rate of
10% per annum (or such lesser maximum amount that is permitted to be paid by applicable law, and calculated on the basis of a year consisting of 360 days) to such Holder, accruing daily from the date such liquidated damages are due until such
amounts, plus all such interest thereon, are paid in full. Notwithstanding the foregoing, in the event a Registration Default occurs pursuant to clause (iii) hereof, the liquidated damages referred to above for any Penalty Period shall be
reduced to equal the percentage determined by multiplying 1% by a fraction, the numerator of which shall be the number of Registrable Securities covered by the Registration Statement that is suspended by the Company or ceases to remain continuously
effective as to all Registrable Securities for which it is required to be effective which are still Registrable Securities at such time and for which there is not otherwise an effective Registration Statement at such time and the denominator of
which shall be the number of Registrable Securities at such time. Notwithstanding the foregoing, nothing shall preclude any Holder from pursuing or obtaining any available remedies at law, specific performance or other equitable relief with respect
to this Section 6 in accordance with applicable law. 

7.        Indemnification. 

(a)        The Company shall indemnify, to the extent permitted by applicable law,
each Holder, its officers, directors, partners, managers, members, investment managers, employees, agents and representatives, and each Person who controls each Holder (within the meaning of Section 15 the Securities Act and Section 20 of
the Exchange Act) against all losses, claims, damages, liabilities and expenses (including reasonable legal expenses) arising out of or based upon (i) any untrue or alleged untrue statement of material fact contained in (or incorporated by
reference therein) any Registration Statement, free writing prospectus, prospectus or preliminary prospectus, filing under any state securities (or blue sky) law or any amendment thereof or supplement thereto or any omission or alleged omission of a
material fact required to be stated therein or necessary to make the statements therein not misleading, (ii) any 

  
 - 10 - 

 
violation or alleged violation by the Company of the Securities Act, the Exchange Act, any other law, including any state securities law, or any rule or regulation thereunder relating to the
offer or sale of the Registrable Securities pursuant to a Registration Statement, or (iii) any breach or violation of this Agreement; provided, however, that the Company shall not be liable to any such indemnified party in any such case to the
extent that (A) such claim arises out of or is based upon any untrue statement or alleged untrue statement of a material fact contained in (or incorporated by reference therein) any Registration Statement, free writing prospectus, prospectus or
preliminary prospectus, filing under any state securities (or blue sky) law or any amendment thereof or supplement thereto or any omission or alleged omission of a material fact in reliance upon and in conformity with information furnished to the
Company by or on behalf of such Holder or its representatives by or on behalf of such Holder expressly for use therein, or (B) such claim is related to the use by a Holder or underwriter, if any, of an outdated or defective prospectus after
such party has received written notice from the Company that such prospectus is outdated or defective. 

(b)        Each Holder shall, severally and not jointly, to the extent permitted by
applicable law, indemnify the Company, its directors and officers and each Person who controls the Company (within the meaning of Section 15 the Securities Act and Section 20 of the Exchange Act), to the fullest extent permitted by
applicable law, against any losses, claims, damages, liabilities and expenses (including reasonable legal expenses) arising out of or based upon any untrue or alleged untrue statement of material fact contained in (or incorporated by reference
therein) the Registration Statement, free writing prospectus, prospectus or preliminary prospectus or any amendment thereof or supplement thereto or any omission or alleged omission of a material fact required to be stated therein or necessary to
make the statements herein not misleading, but only to the extent that such untrue statement or omission was made in reliance upon and in conformity with any information furnished in writing to the Company by such Holder or its representatives by or
on behalf of such Holder expressly for use therein; provided that each Holder shall be liable under this Section 7(b) of this Agreement (and otherwise) for only up to the amount of net amount of proceeds actually received by each Holder
as a result of the sale of Registrable Securities pursuant to the Registration Statement giving rise to such indemnification obligation. 

(c)        Any Person entitled to indemnification hereunder shall (i) give
prompt written notice to the indemnifying party of any claim with respect to which it seeks indemnification (provided that the failure to give prompt notice shall not impair any Person’s right to indemnification hereunder to the extent such
failure has not prejudiced the indemnifying party) and (ii) unless, in the Company’s reasonable judgment, a conflict of interest between such indemnified and indemnifying parties may exist with respect to such claim, permit such
indemnifying party to assume the defense of such claim with counsel reasonably satisfactory to the indemnified party. After written notice from the indemnifying party to the indemnified party of its election to assume the defense of such claim, the
indemnifying party shall not be subject to any liability for any settlement subsequently made by the indemnified party without its consent (but such consent shall not be unreasonably withheld, conditioned or delayed). An indemnifying party who is
not entitled to, or elects not to, assume the defense of a claim shall not be obligated to pay the fees and expenses of more than one counsel for all parties indemnified by such indemnifying party with respect to such claim, unless in the reasonable
judgment of the Company, a conflict of interest may exist between such indemnified party and any other of such 

  
 - 11 - 

 
indemnified parties with respect to such claim, in which case the indemnifying party shall be liable for the fees and expenses of one additional firm of attorneys with respect to the indemnified
parties. The indemnifying party shall keep the indemnified party reasonably apprised at all times as to the status of the defense or any settlement negotiations with respect to such claim. No indemnifying party shall, without the prior written
consent of the indemnified party, consent to entry of any judgment or enter into any settlement or other compromise which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a full
release from all liability with respect to such claim. 
 (d)        The
indemnification provided for under this Agreement shall remain in full force and effect regardless of any investigation made by or on behalf of the indemnified party or any officer, director, partner, manager, member, investment manager, employee,
agent, representative or controlling Person of such indemnified party and shall survive the transfer of Registrable Securities. The indemnity agreements contained herein shall be in addition to (i) any cause of action or similar right of the
indemnified party against the indemnifying party or others, and (ii) any liabilities to which the indemnifying party may be subject pursuant to the law. 

(e)        If the indemnification provided for in this Section 7 of this
Agreement is unavailable to or is insufficient to hold harmless an indemnified party under the provisions above in respect to any losses, claims, damages or liabilities referred to therein, then the indemnifying party shall contribute to the amount
paid or payable by such indemnified party as a result of such losses, claims, damages or liabilities to the fullest extent permitted by law; provided, however, that: (i) no Person involved in the sale of Registrable Securities which Person is
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) in connection with such sale shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation, and
(ii) contribution by each Holder shall be limited in amount to the net amount of proceeds actually received by such Holder from the sale of such Registrable Securities pursuant to the applicable Registration Statement, less the amount of any
damages that such Holder has otherwise been required to pay in connection with such sale. 

8.        Reports under the Exchange Act. With a view to making available to
the each Holder the benefits of Rule 144 under the Securities Act or any other similar rule or regulation of the Securities and Exchange Commission that may at any time permit a Holder to sell securities of the Company to the public without
registration (“Rule 144”), at all times during which there are Registrable Securities outstanding that have not been previously (i) sold to or through a broker or dealer or underwriter in a public distribution or
(ii) sold in a transaction exempt from the registration and prospectus delivery requirements of the Securities Act under Section 4(1) thereof, in the case of either clause (i) or clause (ii) in such a manner that, upon the
consummation of such sale, all transfer restrictions and restrictive legends with respect to such shares are removed upon the consummation of such sale, the Company agrees to use its best efforts to: 

(a)        make and keep public information available, as those terms are understood
and defined in Rule 144; 
 (b)        file with the Securities and Exchange
Commission in a timely manner all reports and other documents required of the Company under the Exchange Act, so long as the Company remains subject to such requirements and the filing of such reports and other documents is required for the
applicable provisions of Rule 144; and 

  
 - 12 - 

 (c)        furnish to each Holder so
long as such Holder owns Registrable Securities, promptly upon request, a written statement by the Company, if true, that it has complied with the reporting requirements of Rule 144 and the Exchange Act. 

9.        Preservation of Rights. Without the prior written consent of a
Majority-in-Interest, the Company shall not, on or after the date of this Agreement, (i) grant any registration rights to third parties which are more favorable than or inconsistent with the rights granted hereunder, or (ii) enter into any
agreement, take any action, or permit any change to occur, with respect to its securities that is inconsistent with or violates or subordinates the rights expressly granted to each Holder in this Agreement, such as (A) affecting the ability of
each Holder to include the Registrable Securities in a registration undertaken pursuant to this Agreement, or (B) affecting the marketability of such Registrable Securities in any such registration (including effecting a stock split or a
combination of shares). In the event any holder of Common Stock, or securities convertible into Common Stock, shall be granted Piggyback Registration Rights, the Holder will have the right to exercise the same Piggyback Registration Rights on a pro
rata basis. 
 10.        Definitions. 

“Affiliate” means (i) any Person that directly, or indirectly through one or more intermediaries, controls, is
controlled by or is under common control with such other Person, (ii) any executive officer or general partner of such other Person and (iii) any legal entity for which such Person acts as executive officer or general partner, and
“control” for these purposes means the direct or indirect power to direct or cause the direction of the management and policies of another Person, whether by operation of law or regulation, through ownership of securities, as
trustee or executor or in any other manner. 
 “Business Day” means any day on which the principal offices of the
Securities and Exchange Commission in Washington, DC are open to accept filings. 
 “Commission
Guidance” means (i) any publicly available written guidance or rule of general applicability of the Securities and Exchange Commission staff or (ii) written comments, requirements or requests of the Securities and Exchange
Commission staff to the Company in connection with the review of a Registration Statement. 
 “Common
Stock” means the common stock, par value $0.0001 per share, of the Company, and includes all securities of the Company issued or issuable with respect to such securities by way of a stock split, stock dividend, or in exchange for or
upon conversion of such shares or otherwise in connection with a combination of shares, distribution, recapitalization, merger, consolidation, or other corporate reorganization. 

“Demand Registration” means a Shelf Registration or a Long-Form Registration. 

“Effectiveness Date” means, with respect to the Registration Statement required to be filed under
Section 1(a), the earlier of (a) the 90th calendar day following the date of filing of the Registration Statement and (b) five (5) Business Days following the date the Commission informs the Company that it (i) will
not review the Registration Statement or (ii) has no further 

  
 - 13 - 

 
comments; provided, however, that, if the Company receives written comments from the Commission relating to the filed Registration Statement (including any exhibits thereto or reports
incorporated by reference therein), then the Effectiveness Date shall be the earlier of (x) the 120th calendar day following the date of filing of the Registration Statement and (y) five (5) Business Days following the date the
Commission informs the Company that it (i) will not review the Registration Statement or (ii) has no further comments; provided, further, however, that if the Effectiveness Date falls on a day that is not a Business Day, then the
Effectiveness Date shall be extended to the next Business Day. 
 “Exchange Act” means the Securities Exchange Act
of 1934, as amended from time to time, and the rules and regulations promulgated thereunder. 
 “Filing Date” means,
with respect to the Registration Statement required to be filed under Section 1(a), a date which is nine (9) months following the date hereof. 

“FINRA” means the Financial Industry Regulatory Authority, and any agency or authority succeeding to
the functions thereof. 
 “Holder” means (i) the Stockholder in its capacity as a holder of
record of Registrable Securities, (ii) any Affiliate of the Stockholder that is a direct or indirect transferee of Registrable Securities from the Stockholder or any subsequent Holder and (iii) any direct or indirect transferee of
Registrable Securities from the Stockholder or any subsequent Holder. 
 “Majority-in-Interest”
means Holders of more than fifty percent (50%) of the Registrable Securities. 
 “Person” means
an individual, a partnership, a corporation, a limited liability company, an association, a joint stock company, a trust, a joint venture, an unincorporated organization or a governmental entity (or any department, agency or political subdivision
thereof). 
 “Piggyback Registration Right” means the right of a holder of any class of securities
of the Company to register the resale of such securities pursuant to a registration initiated by the Company other than upon the demand of such holder. 

“Registrable Securities” means the Shares, together with any securities issued or issuable upon any
stock split, dividend or other distribution, recapitalization or similar event with respect to the foregoing. For purposes of this Agreement, a Person shall be deemed to be a holder of Registrable Securities whenever such Person has the right to
acquire such Registrable Securities (upon conversion or exercise, in connection with a transfer of securities or otherwise, but disregarding any restrictions or limitations upon the exercise of such right), whether or not such acquisition has
actually been effected. As to any particular Registrable Securities, such securities shall cease to be Registrable Securities when (A) a Registration Statement covering such securities has been declared effective by the Securities and Exchange
Commission and such securities have been disposed of pursuant to such effective Registration Statement, (B) such securities are otherwise transferred and such securities may be resold without limitation or subsequent registration under the
Securities Act, or (C) such securities shall have ceased to be outstanding. 

  
 - 14 - 

 “Registration Statement” means any registration statement
of the Company which covers any of the Registrable Securities pursuant to the provisions of this Agreement, including the prospectus, amendments, and supplements to the Registration Statement, including post-effective amendments, all exhibits and
all materials incorporated by reference in the Registration Statement. 
 “Securities Act” means the
Securities Act of 1933, as amended from time to time, and the rules and regulations promulgated thereunder. 

“Securities and Exchange Commission” means the United States Securities and Exchange Commission, and
any governmental body or agency succeeding to the functions thereof. 

11.        Miscellaneous. 

(a)        Remedies. Each Party shall be entitled to enforce its rights under
any provision of this Agreement specifically to recover damages caused by reason of any breach of any provision of this Agreement and to exercise all other rights granted by applicable law. The Parties agree and acknowledge that money damages may
not be an adequate remedy for any breach of the provisions of this Agreement and that any Party may, in its sole discretion, apply to any court of law or equity of competent jurisdiction (without posting any bond or other security) for specific
performance and for other injunctive relief in order to enforce or prevent violation of the provisions of this Agreement. 

(b)        Termination. All rights and obligations of the Company hereunder
other than pursuant to Sections 5 and 6 hereof shall terminate on the date on the earlier of (i) the date on which all Registrable Securities may be sold without restriction pursuant to Rule 144 including, without limitation,
volume limitations and other restrictions of Rule 144 and (ii) the date on which no Registrable Securities are outstanding. 

(c)        Amendments and Waivers. Except as otherwise provided herein, the
provisions of this Agreement may be amended, modified or waived only upon the prior written consent of the Company, a Majority-in-Interest and any Holder that would be materially and disproportionately affected by such an amendment or waiver. The
failure of any party to enforce any of the provisions of this Agreement shall in no way be construed as a waiver of such provisions and shall not affect the right of such party thereafter to enforce each and every provision of this Agreement in
accordance with its terms. 
 (d)        Assignment; No Third Party
Beneficiaries. This Agreement and the rights, duties and obligations of the Company hereunder may not be assigned or delegated by the Company in whole or in part. This Agreement and the rights, duties and obligations of the Holders hereunder may
be freely assigned or delegated by such Holder in conjunction with and to the extent of any transfer of Registrable Securities. This Agreement and the provisions hereof shall be binding upon and shall inure to the benefit of each of the Parties and
their respective permitted successors and assigns; provided, however, that no such transfer or assignment shall be binding upon or obligate the Company to any such assignee, and no such assignee shall be deemed a Holder hereunder, unless and until
the Company shall have received written notice of 

  
 - 15 - 

 
such transfer or assignment as herein provided and a written agreement of the assignee to be bound by the provisions of this Agreement. This Agreement is not intended to confer any rights or
benefits on any Persons that are not party hereto other than as expressly set forth in Section 6 and this Section 11(d). 

(e)        Severability. Whenever possible, each provision of this Agreement
shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited by or invalid under applicable law, such provision shall be ineffective only to the extent of such
prohibition or invalidity, without invalidating the remainder of this Agreement. 

(f)        Counterparts. This Agreement may be executed in one or more
counterparts, all of which shall be considered one and the same agreement and shall become effective when one or more counterparts have been signed by each Party to this Agreement and delivered to the other Party, it being understood that all
Parties need not sign the same counterpart. Signatures delivered by electronic methods shall have the same effect as signatures delivered in person. 

(g)        Descriptive Headings. The descriptive headings of this Agreement
are inserted for convenience only and do not constitute a part of this Agreement. 

(h)        Governing Law; Waiver of Jury Trial. This Agreement shall be
governed by and construed in accordance with the internal laws of New York applicable to parties residing in New York, without regard applicable principles of conflicts of law. Each Party irrevocably consents to the exclusive jurisdiction of any
court located within New York County, New York, in connection with any matter based upon or arising out of this Agreement or the matters contemplated hereby and it agrees that process may be served upon it in any manner authorized by the laws of the
State of New York for such Persons and waives and covenants not to assert or plead any objection which it might otherwise have to such jurisdiction and such process. EACH PARTY TO THIS AGREEMENT ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY
ARISE UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE, IT HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING
OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. EACH PARTY TO THIS AGREEMENT CERTIFIES AND ACKNOWLEDGES THAT (I) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT
SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE EITHER OF SUCH WAIVERS, (II) IT UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF SUCH WAIVERS, (III) IT MAKES SUCH WAIVERS VOLUNTARILY, AND (IV) IT HAS BEEN INDUCED TO ENTER
INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 11(h). 

(i)        Notices. All notices and other communications hereunder shall be in
writing and shall be deemed duly delivered: (i) upon receipt if delivered personally; (ii) three (3) Business Days after being mailed by registered or certified mail, postage prepaid, return receipt

  
 - 16 - 

 
requested; (iii) one (1) Business Day after it is sent by commercial overnight courier service; or (iv) upon transmission if sent via facsimile or electronic mail with confirmation
of receipt to the Parties to this Agreement at the addresses set forth in the Purchase Agreement (or at such other address for a Party as shall be specified upon like notice). 

(j)        Rules of Construction. The Parties agree that they have each been
represented by counsel during the negotiation, preparation and execution of this Agreement (or, if executed following the date hereof by counterpart, have been provided with an opportunity to review the Agreement with counsel) and, therefore, waive
the application of any law, regulation, holding or rule of construction providing that ambiguities in an agreement or other document will be construed against the Party drafting such agreement or document. 

(k)        Interpretation. This Agreement shall be construed in accordance
with the following rules: (i) the terms defined in this Agreement include the plural as well as the singular; (ii) all references in the Agreement to designated “Sections” and other subdivisions are to the designated sections and
other subdivisions of the body of this Agreement; (iii) pronouns of either gender or neuter shall include, as appropriate, the other pronoun forms; (iv) the words “herein,” “hereof” and “hereunder” and other
words of similar import refer to this Agreement as a whole and not to any particular Section or other subdivision; and (v) the words “includes” and “including” are not limiting. 

[Remainder of page intentionally left blank. Signature Pages Follow.] 

  
 - 17 - 

 IN WITNESS WHEREOF, the Parties have executed this Agreement on the date first
above written. 
  

			
	COMPANY:
	
	Ignyta, Inc.
		
	By:		/s/ Jonathan E. Lim, M.D.
	Name:		Jonathan E. Lim, M.D.
	Title:		President and Chief Executive
	Officer
	
	STOCKHOLDER:
	
	Cephalon, Inc.
		
	By:		 /s/ Deborah Griffin

	Name:		  

	Title:		  

 
			
		
	By:		 /s/ Ivana Liebisch

	Name:		  

	Title:		  

 Registration Rights Agreement

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