Document:

PROMISSORY
NOTE

 

	$3,000.00	November 4, 2019

 

FOR VALUE RECEIVED,
the undersigned, Magna-Lab Inc., a New York corporation (“Borrower”), HEREBY PROMISES TO PAY to
the order of Magna Acquisition LLC or its registered assigns ( “Lender”), in lawful money of the United
States of America, in the manner and at the times provided hereinafter, the principal sum of Three Thousand Dollars (US$3,000),
together with Interest (as hereinafter defined) and Default Interest (as hereinafter defined) and all other amounts due and payable
pursuant to and in accordance with terms of this Note.

 

Interest shall accrue
on the unpaid principal amount of this Note from the date hereof until such principal amount is paid in full. “Interest”
shall mean ten percent (10%) per annum. Interest shall be computed on the actual number of days elapsed, predicated on a year consisting
of three hundred and sixty (360) days.

 

Default Interest, if
any, shall be payable on demand. “Default Interest” shall mean interest computed at twelve percent (12%) per
annum, on (i) the entire principal balance of this Note from time to time unpaid from and after such amounts becomes due and payable
(whether upon maturity, by acceleration or otherwise), and (ii) any and all other unpaid amounts due pursuant to the terms and
provisions of this Note (including, but not limited to, accrued and unpaid Interest) from and after the respective date(s) on which
those amounts become due and payable, whether upon maturity, by acceleration or otherwise; in each case from and after the expiration
of any applicable grace period. Default Interest shall be computed on the actual number of days elapsed, predicated on a year consisting
of three hundred and sixty (360) days. Notwithstanding anything to the contrary contained herein, for any period in which Default
Interest is accruing on the entire unpaid principal balance hereunder, Interest shall not accrue. Default Interest shall compound
on an annual basis.

 

Unless otherwise accelerated
pursuant to the terms hereof, this Note shall mature and all outstanding and unpaid principal and Interest shall be due and payable
on the date that is 120 days from and after the date hereof.

 

This Note may be prepaid,
in whole or in part, at any time by Borrower without premium or penalty. Any prepayment of this Note shall be accompanied by payment
of any Interest accrued and unpaid through the date of such prepayment, and all Default Interest, if any, accrued and unpaid through
the date of such prepayment.

 

Notwithstanding anything
to the contrary contained herein, upon the occurrence of any one or more of: (i) a default in the payment of any amounts due hereunder
and a failure to cure such default within five (5) business days, or (ii) a default hereunder, and the expiration of any grace
period applicable to any default as set forth herein, then at the sole option and discretion of Lender, and without further demand
or notice of any kind, the following shall become immediately due and payable:

 

		1.	the aggregate principal amount of this Note outstanding and remaining unpaid hereunder;

 

		2.	unpaid Interest;

 

		3.	Default Interest; and

 

		4.	all other indebtedness evidence by this Note.

 

    

    

    

 

The following shall constitute events of
default hereunder: (i) the assignment for the benefit of creditors by Borrower; (ii) the application for the appointment of a receiver
for Borrower or for the property of Borrower; (iii) the filing of a petition in bankruptcy by or against Borrower; (iv) the issuance
of an attachment or the entry of a judgment against Borrower; (v) a default by Borrower with respect to any other indebtedness
due to Lender; (vi) the making or sending of a notice of an intended bulk sale by Borrower; (vii) the merger, consolidation, termination
of existence, dissolution or insolvency of Borrower; (viii) the good faith determination by Lender that it deems itself insecure
or that a material adverse change in the financial condition of Borrower has occurred since the date hereof and that Lender’s
prospect of payment hereunder has been impaired; or (ix) any breach or default under any indebtedness of Borrower to any banking
or financial institution, and the expiration of any grace period applicable to such breach or default.

 

If Borrower fails to
pay any amounts when due hereunder, whether at maturity, by acceleration or otherwise, or if there occurs any event which entitles
Lender to accelerate the indebtedness due under this Note and any grace period applicable to any such failure to pay or event as
set forth herein expires, then Lender shall have all of the rights and remedies provided to it hereunder, and at law or in equity.
The remedies of Lender, as provided herein, shall be cumulative and concurrent, and may be pursued singularly, successively, or
otherwise, at the sole discretion of Lender, and may be exercised as often as occasion therefor shall arise. Lender may resort
for payment hereunder to any of security for, or any guaranty of, this Note whether or not Lender shall have resorted for payment
hereunder to any other security for or guaranty of this Note. No act or omission of Lender, including specifically any failure
to exercise any right, remedy or recourse, shall be deemed to be a waiver or release of the same, such waiver or release to be
effected only through a written document executed by Lender and then only to the extent specifically recited therein. A waiver
or release with reference to any one event shall not be construed as continuing, as a bar to, or as a waiver or release of, any
subsequent right, remedy, or recourse as to a subsequent event. If this Note is placed in the hands of an attorney for collection
or is collected on advice of counsel or through any legal proceeding, Borrower promises to pay, to the extent permitted by law,
court costs and reasonable attorneys’ fees incurred by Lender. Borrower hereby waives presentment, demand, notice of dishonor
or nonpayment, protest and notice of protest in connection therewith.

 

If any provision of
this Note is unenforceable, invalid or contrary to law, or its inclusion herein would affect the validity, legality or enforcement
of this Note, such provision shall be limited to the extent necessary to render the same valid or shall be excised from this Note,
as the circumstances require, and this Note shall be construed as if said provision had been incorporated herein as so limited
or as if said provision had not been included herein, as the case may be.

 

Time is of the essence
of this Note.

 

Upon maturity or following
the occurrence of any event which entitles Lender to accelerate the indebtedness evidenced hereby, all payments received on account
of the indebtedness evidenced hereby shall be applied, in whatever order, combination and amounts as Lender, in its sole and absolute
discretion, decides, to all costs, expenses and other indebtedness, if any, owing to Lender by reason of this Note; Default Interest,
Interest; and principal.

 

This Note, and the
terms and provisions hereof, shall be binding upon Borrower and its successors, administrators, and assigns, and shall inure to
the benefit of any holder hereof.

 

All amounts due hereunder
shall be paid without deduction, set-off or counterclaim, Borrower expressly waiving any such rights to deduction, set-off or counterclaim.

 

    

    

    

 

Notwithstanding any
provisions to the contrary contained in this Note or in any of the other documents or instruments referred to in this Note, if
at any time or times the interest and any sums considered for such purposes to be interest, payable under or by reason of this
Note or any such other documents or instruments, should exceed the maximum which, by the laws of the State having jurisdiction,
may be charged with respect to the loan evidenced hereby, given the nature and all of the pertinent circumstances of such loan,
than all such sums in excess of such maximum shall be deemed not to be interest, but rather to be payments on account of principal,
and without further agreement of the parties shall be so applied without regard to any other provision of this Note, provided that
Lender may elect instead that no sums shall be payable in excess of such maximum, whereupon this Note, and such other documents
and instruments hall be deemed amended accordingly without further action by any party.

 

This Note shall inure
to the benefit of Lender and its successors and assigns and shall be governed by, and construed in accordance with, the laws of
the State of Delaware.

 

 

	 	MAGNA-LAB INC., a New York corporation
	 	 
	 	By /s/ Lawrence  A. Minkoff
	 	      Name: Lawrence A. Minkoff
	 	      Title: Chairman and PresidentExhibit 10.1 

 

Execution Version

 

SHARE TRANSFER AGREEMENT

 

SHARE TRANSFER AGREEMENT
(the “Agreement”), dated as of January 10, 2020, by and between AXSOME THERAPEUTICS, INC., a Delaware
corporation (the “Company”), and PFIZER INC. (the “Investor”).

 

WHEREAS:

 

Subject to the terms and conditions set
forth in this Agreement, in consideration for entering into that certain License Agreement, by and between the Company and the
Investor, the Company agrees to issue to Investor 82,019 shares (the “Shares”) of the Company's common stock,
$0.0001 par value per share (the “Common Stock”), based on an assumed issuance price of $97.538001 per share,
which is the average closing price of the Company’s Common Stock on the Principal Market for the ten (10) consecutive trading
days immediately preceding the date of this Agreement, for a total issuance value of $8,000,000.

 

NOW THEREFORE, in consideration of the
mutual covenants contained in this Agreement, and for other good and valuable consideration, the receipt and adequacy of which
are hereby acknowledged, the Company and the Investor hereby agree as follows:

 

1.       CERTAIN
DEFINITIONS. 

 

For purposes of this
Agreement, the following terms shall have the following meanings:

 

(a)      “Bankruptcy
Law” means Title 11, U.S. Code, or any similar federal or state law for the relief of debtors.

 

(b)      “Business
Day” means any day on which the Principal Market is open for trading, including any day on which the Principal Market
is open for trading for a period of time less than the customary time.

 

(c)      “Confidential
Information” has the meaning set forth in the License Agreement.

 

(e)      “Custodian”
means any receiver, trustee, assignee, liquidator or similar official under any Bankruptcy Law.

 

(f)       “DTC”
means The Depository Trust Company, or any successor performing substantially the same function for the Company.

 

(g)      “DWAC
Shares” means shares of Common Stock that are (i) issued in electronic form, (ii) freely tradable and transferable and
without restriction on resale and (iii) timely credited by the Company to the Investor or its designee’s specified Deposit/Withdrawal
at Custodian (DWAC) account with DTC under its Fast Automated Securities Transfer (FAST) Program or any similar program hereafter
adopted by DTC performing substantially the same function.

 

(h)      “Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 

(i)       “License
Agreement” means that certain License Agreement, by and between the Company and the Investor entered into on even date
herewith.

 

     

     

    

 

(j)       “Lock
Up Provisions” means the provisions attached hereto as Exhibit C.

 

(k)      “Material
Adverse Effect” means any material adverse effect on (i) the enforceability of any Transaction Document, (ii) the
results of operations, assets, business or financial condition of the Company and its Subsidiaries, taken as a whole, other than
any material adverse effect that resulted primarily from (A) any change in the United States or foreign economies or securities
or financial markets in general that does not have a disproportionate effect on the Company and its Subsidiaries, taken as a whole,
(B) any change that generally affects the industry in which the Company and its Subsidiaries operate that does not have a
disproportionate effect on the Company and its Subsidiaries, taken as a whole, (C) any change arising in connection with earthquakes,
hostilities, acts of war, sabotage or terrorism or military actions or any escalation or material worsening of any such hostilities,
acts of war, sabotage or terrorism or military actions existing as of the date hereof, (D) any action taken by the Investor,
its affiliates or its successors and assigns with respect to the transactions contemplated by this Agreement, (E) the effect
of any change in applicable laws or accounting rules that does not have a disproportionate effect on the Company and its Subsidiaries,
taken as a whole, (F) any change resulting from compliance with terms of this Agreement or the consummation of the transactions
contemplated by this Agreement, or (G) any change, in and of itself, in the Company’s stock price or trading volume from
and after the date hereof (provided, however, that the facts and circumstances underlying any such change may, except as provided
in subsections (A), (B), (C), (D), (E) or (F) of this definition, be considered in determining whether a Company Material Adverse
Effect has occurred), or (iii) the Company’s ability to perform in any material respect on a timely basis its obligations
under any Transaction Document to be performed as of the date of determination.

 

(l)       “Person”
means an individual or entity including but not limited to any limited liability company, a partnership, a joint venture, a corporation,
a trust, an unincorporated organization and a government or any department or agency thereof.

 

(m)     “Principal
Market” means The Nasdaq Global Market (or any nationally recognized successor thereto); provided, however, that in the
event the Company’s Common Stock is ever listed or traded on The Nasdaq Capital Market, The Nasdaq Global Select Market,
the New York Stock Exchange, the NYSE American, the NYSE Arca, the OTC Bulletin Board, or the OTCQX or the OTCQB operated by the
OTC Markets Group, Inc. (or any nationally recognized successor to any of the foregoing), then the “Principal Market”
shall mean such other market or exchange on which the Company’s Common Stock is then listed or traded.

 

(n)      “SEC”
means the U.S. Securities and Exchange Commission.

 

(o)      “Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 

(p)      “Subsidiary”
means any Person the Company wholly-owns or controls, or in which the Company, directly or indirectly, owns a majority of the voting
stock or similar voting interest, in each case that would be disclosable pursuant to Item 601(b)(21) of Regulation S-K promulgated
under the Securities Act.

 

(q)      “Transaction
Documents” means, collectively, this Agreement and the schedules and exhibits hereto, including the Lock Up Provisions,
and the License Agreement and each of the other documents, certificates and instruments entered into or furnished by the parties
hereto in connection with the transactions contemplated hereby and thereby.

 

(r)       “Transfer
Agent” means American Stock Transfer & Trust Company, LLC, or such other Person who is then serving as the transfer
agent for the Company in respect of the Common Stock.

 

    -2-

     

    

 

2.       ISSUANCE OF COMMON STOCK. 

 

(a)      Issuance
of Common Stock. Subject to the terms and conditions set forth in this Agreement, on the Effective Date of the License Agreement
(“Closing Date”), the Company shall issue or cause to be issued to the Investor 82,019 Shares, free and clear
of all liens (other than liens imposed by applicable securities laws or contained herein).

 

(b)      Deliveries at Closing. At the Closing, the Company shall deliver or cause to be delivered to the Investor the following
items:

 

(i)    
evidence of the filing of the Listing of Additional Shares notification to the Nasdaq Global Market as it relates to the
Shares;

 

(ii)   
a copy of the Irrevocable Transfer Agent Instructions;

 

(iii)  
an opinion of DLA Piper LLP, counsel for the Company, addressed to the Investor, and dated the Closing Date, in substantially
the form attached hereto as Exhibit D; and

 

(iv) 
all such other documents, certificates and instruments as the Purchaser may reasonably request in order to give effect to
the transactions contemplated hereby.

 

3.       INVESTOR’S
REPRESENTATIONS AND WARRANTIES.

 

The Investor represents
and warrants to the Company that as of the date hereof and as of the Closing Date:

 

(a)      Organization,
Authority. Investor is an entity duly organized, validly existing and in good standing under the laws of the jurisdiction of
its organization, with the requisite power and authority to enter into and to consummate the transactions contemplated by this
Agreement and otherwise to carry out its obligations hereunder and thereunder.

 

(b)      Accredited
Investor Status. The Investor is an “accredited investor” as that term is defined in Rule 501(a)(3) of Regulation
D promulgated under the Securities Act.

 

(c)      Information.
The Investor understands that its investment in the Shares involves a high degree of risk. The Investor (i) is able to bear the
economic risk of an investment in the Shares including a total loss thereof, (ii) has such knowledge and experience in financial
and business matters that it is capable of evaluating the merits and risks of the proposed investment in the Shares and (iii) has
had an opportunity to ask questions of and receive answers from the officers of the Company concerning the financial condition
and business of the Company and others matters related to an investment in the Shares. Neither such inquiries nor any other due
diligence investigations conducted by the Investor or its representatives shall modify, amend or affect the Investor's right to
rely on the Company's representations and warranties contained in Section 4 below. The Investor has sought such accounting, legal
and tax advice from its own independent advisors as it has considered necessary to make an informed investment decision with respect
to its acquisition of the Shares.

 

    -3-

     

    

 

(d)      Acquisition
for Investment. The Investor is acquiring the Shares solely for its own account for the purpose of investment and not with
a view to or for sale in connection with the distribution thereof. The Investor does not have a present intention to sell any of
the Shares, nor a present arrangement (whether or not legally binding) or intention to effect any distribution of any of the Shares
to or through any Person.

 

(e)      No
Governmental Review. The Investor understands that the Shares are being offered and issued in reliance on a transactional exemption
from the registration requirements of United States federal and state securities laws and the Company is relying in part upon the
truth and accuracy of the representations, warranties, agreements, acknowledgments and understandings of the Investor set forth
herein in order to determine the availability of such exemptions and the suitability of the Investor to acquire the Shares. The
Investor understands that no U.S. federal or state agency or any other government or governmental agency has passed on or made
any recommendation or endorsement of the Shares or the fairness or suitability of an investment in the Shares nor have such authorities
passed upon or endorsed the merits of the offering of the Shares.

 

(f)       Validity;
Enforcement. This Agreement has been duly and validly authorized, executed and delivered on behalf of the Investor and is a
valid and binding agreement of the Investor enforceable against the Investor in accordance with its terms, subject as to enforceability
to general principles of equity and to applicable bankruptcy, insolvency, reorganization, moratorium, liquidation and other similar
laws relating to, or affecting generally, the enforcement of applicable creditors' rights and remedies.

 

(g)       Residency.
The Investor is a corporation existing under the laws of Delaware with offices in the State of New York.

 

(h)       Rule
144. The Investor understands that the Shares must be held indefinitely unless such Shares are registered under the Securities
Act or an exemption from registration is available. The Investor acknowledges that it is familiar with Rule 144 of the rules and
regulations of the SEC, promulgated pursuant to the Securities Act (“Rule 144”), and that the Investor has been
advised that Rule 144 permits resales only under certain circumstances. The Investor understands that to the extent that Rule 144
is not available, the Investor will be unable to sell any Shares without either registration under the Securities Act or the existence
of another exemption from such registration requirement. Following expiration of the Lock Up Period, provided the Investor otherwise
complies with the requirements of Rule 144, the Investor may request, and the Company shall promptly (within two (2) business days)
have its legal counsel deliver an opinion to the Transfer Agent requesting removal of the restrictive legend(s) appended to Investor’s
book-entry statement(s) pursuant to Section 6(c). Any fees (with respect to the Transfer Agent, counsel to the Company or otherwise)
associated with the issuance of such opinion shall be borne by the Company. By signing this Agreement, the Investor agrees to be
bound by the terms of the Lock Up Provisions.

 

    -4-

     

    

 

4.       REPRESENTATIONS
AND WARRANTIES OF THE COMPANY.

 

The Company represents
and warrants to the Investor that as of the date hereof and as of the Closing Date:

 

(a)      Organization
and Qualification. The Company and each of its Subsidiaries is an entity duly incorporated or otherwise organized, validly
existing and in good standing under the laws of the jurisdiction of its incorporation or organization, with the requisite corporate
power and authority to own and use its properties and assets and to carry on its business as currently conducted.  Neither
the Company nor any of its Subsidiaries is in violation or default of any of the provisions of its respective certificate or articles
of incorporation, bylaws or other organizational or charter documents.  Each of the Company and its Subsidiaries is duly
qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the
nature of the business conducted or property owned by it makes such qualification necessary, except where the failure to be so
qualified or in good standing, as the case may be, could not have or reasonably be expected to result in a Material Adverse Effect
and no proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing or seeking to revoke, limit or
curtail such power and authority or qualification. The Company has no Subsidiaries except as set forth on Exhibit 21.1 to the Company’s
Annual Report on Form 10-K for the year ended December 31, 2018.

 

(b)      Authorization;
Enforcement; Validity. (i) The Company has the requisite corporate power and authority to enter into and perform its obligations
under this Agreement and each of the other Transaction Documents, and to issue the Shares in accordance with the terms hereof and
thereof, (ii) the execution and delivery of this Agreement and each of the other Transaction Documents by the Company and the consummation
by it of the transactions contemplated hereby and thereby, including without limitation, the issuance of the Shares pursuant to
this Agreement, have been duly authorized by the Company's Board of Directors and no further consent or authorization is required
by the Company, its Board of Directors or its stockholders, (iii) this Agreement has been and each of the other Transaction Document
shall be on the Closing Date, duly executed and delivered by the Company and (iv) this Agreement constitutes, and each other Transaction
Document upon its execution on behalf of the Company on the Closing Date, shall on the Closing Date constitute, the valid and binding
obligations of the Company enforceable against the Company in accordance with their terms, except as such enforceability may be
limited by general principles of equity or applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar
laws relating to, or affecting generally, the enforcement of creditors' rights and remedies. Except as set forth in this Agreement,
no other approvals or consents of the Company’s Board of Directors, any authorized committee thereof, and/or stockholders
is necessary under applicable laws and the Company’s Certificate of incorporation and/or Bylaws to authorize the execution
and delivery of this Agreement or any of the transactions contemplated hereby, including, but not limited to, the issuance of the
Shares.

 

(c)      Capitalization.
The authorized capital of the Company, immediately prior to the date hereof, consists of 150,000,000 shares of Common Stock, 36,933,217
of which were issued and outstanding, and 10,000,000 shares of preferred stock, $0.0001 par value per share, none of which were
issued and outstanding. Immediately prior to the date hereof, (i) options to acquire 3,455,117 shares of Common Stock have been
granted and are outstanding, and (ii) 3,193,988 shares of Common Stock remained available for future issuance to directors, employees
and consultants of the Company and its Subsidiaries.  As of the Effective Date, warrants to purchase 69,656 shares of Common
Stock were issued and outstanding, consisting of 32,614 warrants with an exercise price of $7.41 per share, 7,875 warrants with
an exercise price of $3.06 per share and 29,167 warrants with an exercise price of $8.10 per share. Except as disclosed in the
SEC Documents (as defined below), (i) no shares of the Company's capital stock are subject to preemptive rights or any other similar
rights or any liens or encumbrances suffered or permitted by the Company, (ii) there are no outstanding debt securities, (iii)
there are no outstanding options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating
to, or securities or rights convertible into, any shares of capital stock of the Company or any of its Subsidiaries, or contracts,
commitments, understandings or arrangements by which the Company or any of its Subsidiaries is or may become bound to issue additional
shares of capital stock of the Company or any of its Subsidiaries or options, warrants, scrip, rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities or rights convertible into, any shares of capital stock of the
Company or any of its Subsidiaries, (iv) there are no agreements or arrangements under which the Company or any of its Subsidiaries
is obligated to register the sale of any of their securities under the Securities Act, (v) there are no outstanding securities
or instruments of the Company or any of its Subsidiaries which contain any redemption or similar provisions, and there are no contracts,
commitments, understandings or arrangements by which the Company or any of its Subsidiaries is or may become bound to redeem a
security of the Company or any of its Subsidiaries, (vi) there are no securities or instruments containing anti-dilution or similar
provisions that will be triggered by the issuance of the Shares as described in this Agreement and (vii) the Company does not have
any stock appreciation rights or "phantom stock" plans or agreements or any similar plan or agreement. The Company has
furnished to the Investor true and correct copies of the Company's certificate of incorporation, as amended and as in effect on
the date hereof (the "Certificate of incorporation"), and the Company's Bylaws, as amended and as in effect on
the date hereof (the "Bylaws"), and summaries of the material terms of all securities convertible into or exercisable
for Common Stock, if any, and copies of any documents containing the material rights of the holders thereof in respect thereto
that are not disclosed in the SEC Documents.

 

    -5-

     

    

 

(d)      Issuance
of Shares. Upon issuance in accordance with the terms and conditions of this Agreement, the Shares shall be duly authorized,
validly issued, fully paid and nonassessable and free from all taxes, liens, charges, restrictions, rights of first refusal and
preemptive rights with respect to the issue thereof, and will be issued in compliance with all federal and state securities laws,
with the holders being entitled to all rights accorded to a holder of shares of Common Stock. The Shares are being issued in accordance
with and in reliance upon the exemption from securities registration afforded by Section 4(a)(2) of the Securities Act, and the
rules and regulations promulgated thereunder, including Regulation D (“Regulation D”), and/or upon such other
exemption from the registration requirements of the Securities Act as may be available with respect to any or all of the investments
to be made hereunder. Upon receipt of the Shares, the Investor will have good and marketable title to such Shares.

 

(e)      No
Conflicts. The execution, delivery and performance of the Transaction Documents by the Company and the consummation by the
Company of the transactions contemplated hereby and thereby (including, without limitation, the issuance of the Shares) will not
(i) result in a violation of the Certificate of incorporation, any Certificate of Designations, Preferences and Rights of any outstanding
series of preferred stock of the Company or the Bylaws or (ii) conflict with, or constitute a default (or an event which with notice
or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or
cancellation of, any agreement, indenture or instrument to which the Company or any of its Subsidiaries is a party, or result in
a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws and regulations
and the rules and regulations of the Principal Market applicable to the Company or any of its Subsidiaries) or by which any property
or asset of the Company or any of its Subsidiaries is bound or affected, except in the case of conflicts, defaults, terminations,
amendments, accelerations, cancellations and violations under clause (ii), which could not reasonably be expected to result in
a Material Adverse Effect. Neither the Company nor its Subsidiaries is in violation of any term of or in default under its Certificate
of incorporation, any Certificate of Designation, Preferences and Rights of any outstanding series of preferred stock of the Company
or Bylaws or their organizational charter or bylaws, respectively. Neither the Company nor any of its Subsidiaries is in violation
of any term of or is in default under any material contract, agreement, mortgage, indebtedness, indenture, instrument, judgment,
decree or order or any statute, rule or regulation applicable to the Company or its Subsidiaries, except for possible conflicts,
defaults, terminations or amendments that could not reasonably be expected to have a Material Adverse Effect. The business of the
Company and its Subsidiaries is not being conducted, and shall not be conducted, in violation of any law, ordinance or regulation
of any governmental entity, except for possible violations, the sanctions for which either individually or in the aggregate could
not reasonably be expected to have a Material Adverse Effect. Except as required under the Securities Act or applicable state securities
laws and the rules and regulations of the Principal Market, the Company is not required to obtain any consent, authorization or
order of, or make any filing or registration with, any court or governmental agency or any regulatory or self-regulatory agency
in order for it to execute, deliver or perform any of its obligations under or contemplated by the Transaction Documents in accordance
with the terms hereof or thereof. Except as set forth elsewhere in this Agreement, all consents, authorizations, orders, filings
and registrations which the Company is required to obtain pursuant to the preceding sentence shall be obtained or effected on or
prior to the Closing Date. Except as disclosed in the SEC Documents, the Company has not received nor delivered any notices or
correspondence from or to the Principal Market, other than notices with respect to listing of additional shares of Common Stock
and other routine correspondence. Except as disclosed in the SEC Documents, the Principal Market has not commenced any delisting
proceedings against the Company.

 

    -6-

     

    

 

(f)       SEC
Documents; Financial Statements. The Company has filed all reports, schedules, forms, statements and other documents required
to be filed by the Company under the Securities Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof,
(the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, being collectively referred
to herein as the “SEC Documents”) on a timely basis or has received a valid extension of such time of filing
and has filed any such SEC Documents prior to the expiration of any such extension.  As of their respective dates, the
SEC Documents complied in all material respects with the requirements of the Securities Act and the Exchange Act, as applicable.
None of the SEC Documents, when filed, contained any untrue statement of a material fact or omitted to state a material fact required
to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were
made, not misleading. The financial statements of the Company included in the SEC Documents comply in all material respects with
applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing.  Such
financial statements have been prepared in accordance with United States generally accepted accounting principles applied on a
consistent basis during the periods involved (“GAAP”), except as may be otherwise specified in such financial
statements or the notes thereto and except that unaudited financial statements may not contain all footnotes required by GAAP,
and fairly present in all material respects the financial position of the Company as of and for the dates thereof and the results
of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end
audit adjustments. Except as set forth in the SEC Documents, the Company has received no notices or correspondence from the SEC
for the one year preceding the date hereof. To the Company’s knowledge, the SEC has not commenced any enforcement
proceedings against the Company.

 

(g)      Absence
of Certain Changes. Except as disclosed in the SEC Documents, since December 31, 2018, there has been no material adverse change
in the business, properties, operations, financial condition or results of operations of the Company or its Subsidiaries. The Company
has not taken any steps, and does not currently expect to take any steps, to seek protection pursuant to any Bankruptcy Law nor
does the Company or any of its Subsidiaries have any knowledge or reason to believe that its creditors intend to initiate involuntary
bankruptcy or insolvency proceedings. The Company is financially solvent and is generally able to pay its debts as they become
due.

 

    -7-

     

    

 

(h)      Absence
of Litigation. There is no action, suit, proceeding, inquiry or investigation before or by any court, public board, government
agency, self-regulatory organization or body pending or, to the knowledge of the Company or any of its Subsidiaries, threatened
against or affecting the Company, the Common Stock or any of the Company's or its Subsidiaries' officers or directors in their
capacities as such, which could reasonably be expected to have a Material Adverse Effect.

 

(i)       Acknowledgment
Regarding Investor's Status. The Company acknowledges and agrees that the Investor is acting solely in the capacity of arm's
length purchaser with respect to the Transaction Documents and the transactions contemplated hereby and thereby. The Company further
acknowledges that the Investor is not acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with
respect to the Transaction Documents and the transactions contemplated hereby and thereby and any advice given by the Investor
or any of its representatives or agents in connection with the Transaction Documents and the transactions contemplated hereby and
thereby is merely incidental to the Investor's purchase of the Shares. The Company further represents to the Investor that the
Company's decision to enter into the Transaction Documents has been based solely on the independent evaluation by the Company and
its representatives and advisors.

 

(j)       No
Integrated Offering. Neither the Company, nor or any of its affiliates, nor any Person acting on their behalf has, directly
or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would
cause this offering of the Shares to be integrated with prior offerings by the Company in a manner that would require stockholder
approval pursuant to the rules of the Principal Market on which any of the securities of the Company are listed or designated.
The issuance and sale of the Shares hereunder does not contravene the rules and regulations of the Principal Market.

 

(k)      Intellectual
Property Rights. The Company and its Subsidiaries own or possess adequate rights or licenses to use all material trademarks,
trade names, service marks, service mark registrations, service names, patents, patent rights, copyrights, inventions, licenses,
approvals, governmental authorizations, trade secrets and rights necessary to conduct their respective businesses as now conducted.
None of the Company's material trademarks, trade names, service marks, service mark registrations, service names, patents, patent
rights, copyrights, inventions, licenses, approvals, government authorizations, trade secrets or other intellectual property rights
have expired or terminated, or, by the terms and conditions thereof, could expire or terminate within two years from the date of
this Agreement. Except as disclosed in the SEC Documents, the Company and its Subsidiaries do not have any knowledge of any infringement
by the Company or its Subsidiaries of any material trademark, trade name rights, patents, patent rights, copyrights, inventions,
licenses, service names, service marks, service mark registrations, trade secret or other similar rights of others, or of any such
development of similar or identical trade secrets or technical information by others, and there is no claim, action or proceeding
being made or brought against, or to the Company's knowledge, being threatened against, the Company or its Subsidiaries regarding
trademark, trade name, patents, patent rights, invention, copyright, license, service names, service marks, service mark registrations,
trade secret or other infringement, which could reasonably be expected to have a Material Adverse Effect.

 

    -8-

     

    

 

(l)       Environmental
Laws. The Company and its Subsidiaries (i) are in compliance with any and all applicable foreign, federal, state and local
laws and regulations relating to the protection of human health and safety, the environment or hazardous or toxic substances or
wastes, pollutants or contaminants (“Environmental Laws”), (ii) have received all permits, licenses or other
approvals required of them under applicable Environmental Laws to conduct their respective businesses and (iii) are in compliance
with all terms and conditions of any such permit, license or approval, except where, in each of the three foregoing clauses, the
failure to so comply could not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect.

 

(m)     Title.
Except as set forth in the SEC Documents, the Company and its Subsidiaries have good and marketable title in fee simple to all
real property owned by them and good and marketable title in all personal property owned by them that is material to the business
of the Company and its Subsidiaries, in each case free and clear of all liens, encumbrances and defects (“Liens”)
and, except for Liens as do not materially affect the value of such property and do not materially interfere with the use made
and proposed to be made of such property by the Company and its Subsidiaries and Liens for the payment of federal, state or other
taxes, the payment of which is neither delinquent nor subject to penalties.  Any real property and facilities held under
lease by the Company and its Subsidiaries are held by them under valid, subsisting and enforceable leases with which the Company
and its Subsidiaries are in compliance with such exceptions as are not material and do not interfere with the use made and proposed
to be made of such property and buildings by the Company and its Subsidiaries.

 

(n)      Insurance.
The Company and each of its Subsidiaries are insured by insurers of recognized financial responsibility against such losses and
risks and in such amounts as management of the Company believes to be prudent and customary in the businesses in which the Company
and its Subsidiaries are engaged. Neither the Company nor any such Subsidiary has been refused any insurance coverage sought or
applied for and neither the Company nor any such Subsidiary has any reason to believe that it will not be able to renew its existing
insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to
continue its business at a cost that would not materially and adversely affect the condition, financial or otherwise, or the earnings,
business or operations of the Company and its Subsidiaries, taken as a whole.

 

(o)      Regulatory
Permits. The Company and its Subsidiaries possess all material certificates, authorizations and permits issued by the appropriate
federal, state or foreign regulatory authorities necessary to conduct their respective businesses, and neither the Company nor
any such Subsidiary has received any notice of proceedings relating to the revocation or modification of any such certificate,
authorization or permit.

 

(p)      Tax
Status. The Company and each of its Subsidiaries has made or filed all federal and state income and all other material tax
returns, reports and declarations required by any jurisdiction to which it is subject (unless and only to the extent that the Company
and each of its Subsidiaries has set aside on its books provisions reasonably adequate for the payment of all unpaid and unreported
taxes) and has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to
be due on such returns, reports and declarations, except those being contested in good faith and has set aside on its books provision
reasonably adequate for the payment of all taxes for periods subsequent to the periods to which such returns, reports or declarations
apply. There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the
officers of the Company know of no basis for any such claim.

 

    -9-

     

    

 

(q)      Transactions
With Affiliates.  Except as set forth
in the SEC Documents, none of the officers or directors of the Company and, to the knowledge of the Company, none of the employees
of the Company is presently a party to any transaction with the Company or any Subsidiary (other than for services as employees,
officers and directors), including any contract, agreement or other arrangement providing for the furnishing of services to or
by, providing for rental of real or personal property to or from, or otherwise requiring payments to or from any officer, director
or such employee or, to the knowledge of the Company, any entity in which any officer, director, or any such employee has a substantial
interest or is an officer, director, trustee or partner, in each case in excess of $120,000 other than for (i) payment of salary
or consulting fees for services rendered, (ii) reimbursement for expenses incurred on behalf of the Company and (iii) other employee
benefits, including stock option agreements under any stock option plan of the Company.

 

(r)       Application
of Takeover Protections. The Company and its board of directors have taken all necessary action, if any, in order to render
inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement)
or other similar anti-takeover provision under the Certificate of incorporation or the laws of the state of its incorporation which
is or could become applicable to the Investor as a result of the transactions contemplated by this Agreement, including, without
limitation, the Company's issuance of the Shares and the Investor's ownership of the Shares.

 

(s)      Disclosure.  Except
with respect to the material terms and conditions of the transactions contemplated by the Transaction Documents that will be timely
publicly disclosed by the Company, subject to terms, conditions and restrictions relating to Confidential Information as set forth
in the License Agreement, the Company confirms that neither it nor any other Person acting on its behalf has provided the Investor
or its agents or counsel with any information that it believes constitutes or might constitute material, non-public information
which is not otherwise disclosed in the SEC Documents.    All of the disclosure furnished by or on behalf of the
Company to the Investor regarding the Company, its business and the transactions contemplated hereby, including the disclosure
schedules to this Agreement, is true and correct and does not contain any untrue statement of a material fact or omit to state
any material fact necessary in order to make the statements made therein, in light of the circumstances under which they were made,
not misleading. The press releases disseminated by the Company during the twelve months preceding the date of this Agreement taken
as a whole do not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein
or necessary in order to make the statements therein, in light of the circumstances under which they were made and when made, not
misleading.  The Company acknowledges and agrees that the Investor neither makes nor has made any representations or
warranties with respect to the transactions contemplated hereby other than those specifically set forth in Section 3 hereof or
in the License Agreement.

 

(t)       Foreign
Corrupt Practices.  Neither the Company,
nor to the knowledge of the Company, any agent or other Person acting on behalf of the Company, has (i) directly or indirectly,
used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political
activity, (ii) made any unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic
political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by the Company (or made
by any Person acting on its behalf of which the Company is aware) which is in violation of law, or (iv) violated in any material
respect any provision of the Foreign Corrupt Practices Act of 1977, as amended.

 

    -10-

     

    

 

(u)      DTC
Eligibility. The Company, through the Transfer Agent, currently participates in the DTC Fast Automated Securities Transfer
(FAST) Program and the Common Stock can be transferred electronically to third parties via the DTC Fast Automated Securities Transfer
(FAST) Program.

 

(v)      Sarbanes-Oxley. The Company is in compliance in all material respects with all provisions of the Sarbanes-Oxley Act of 2002,
as amended, which are applicable to it as of the date hereof.

 

(w)     Certain
Fees. No brokerage or finder’s fees or commissions are or will be payable by the Company to any broker, financial advisor
or consultant, finder, placement agent, investment banker, bank or other Person with respect to the transactions contemplated by
the Transaction Documents. The Investor shall not have any obligation with respect to any fees or with respect to any claims made
by or on behalf of other Persons for fees of a type contemplated in this Section 4(w) that may be due in connection with the transactions
contemplated by the Transaction Documents.

 

(x)      Investment
Company. The Company is not required to be registered as, and immediately following the Closing will not be required to be
registered as, an “investment company” within the meaning of the Investment Company Act of 1940, as amended.

 

(y)      Listing
and Maintenance Requirements. The Common Stock is registered pursuant to Section 12(b) of the Exchange Act, and the Company
has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration of the
Common Stock pursuant to the Exchange Act nor has the Company received any notification that the SEC is currently contemplating
terminating such registration. Except as disclosed in the SEC Documents, the Company has not, in the twelve (12) months preceding
the date hereof, received any notice from any Person to the effect that the Company is not in compliance with the listing or maintenance
requirements of the Principal Market. Except as disclosed in the SEC Documents, the Company is, and has no reason to believe that
it will not in the foreseeable future continue to be, in compliance with all such listing and maintenance requirements.

 

(z)      Accountants.
The Company’s accountants are set forth in the SEC Documents and, to the knowledge of the Company, such accountants are an
independent registered public accounting firm as required by the Securities Act.

 

(aa)    No Market
Manipulation. The Company has not, and to its knowledge no Person acting on its behalf has, (i) taken, directly or
indirectly, any action designed to cause or to result in the stabilization or manipulation of the price of any security of the
Company to facilitate the sale or resale of any of the Shares, (ii) sold, bid for, purchased, or, paid any compensation for
soliciting purchases of, any of the Shares, or (iii) paid or agreed to pay to any Person any compensation for soliciting another
to purchase any other securities of the Company.

 

(bb)   Shell Company
Status. The Company is not currently, and has never been, an issuer identified in Rule 144(i)(1) under the Securities Act.

 

    -11-

     

    

 

5.       COVENANTS.

 

(a)      Filing
of Current Report. The Company agrees that it shall, within one (1) business day of the Closing Date, file with the SEC a report
on Form 8-K relating to the transactions contemplated by, and describing the material terms and conditions of, the Transaction
Documents (the “Current Report”), provided that all such filings shall be in accordance with the terms and conditions
relating to Confidential Information as set forth in the License Agreement.

 

(b)      Form
D; Blue Sky Filings. The Company agrees to timely file a Form D with respect to the Shares as required under Regulation D and
to provide a copy thereof, promptly upon request of the Investor. The Company shall take all such action, if any, as is reasonably
necessary in order to obtain an exemption for or to register or qualify (i) the issuance of the Shares to the Investor under this
Agreement and (ii) any subsequent resale of all Shares by the Investor, in each case, under applicable securities or “Blue
Sky” laws of the states of the United States in such states as is reasonably requested by the Investor from time to time,
and shall provide evidence of any such action so taken to the Investor.

 

(c)      Listing/DTC.
The Company shall (a) take all actions that are necessary, including providing appropriate notice to Nasdaq of the transactions
contemplated by this Agreement, for the Shares to be listed on the Nasdaq Global Market and (b) comply with all listing, reporting,
filing, and other obligations under the rules of Nasdaq and of the SEC. The Company shall use commercially reasonable efforts to
maintain the listing of the Common Stock on the Principal Market and shall comply in all respects with the Company’s reporting,
filing and other obligations under the bylaws or rules and regulations of the Principal Market. Neither the Company nor any of
its Subsidiaries shall take any action that would reasonably be expected to result in the delisting or suspension of the Common
Stock on the Principal Market. The Company shall pay all fees and expenses in connection with satisfying its obligations under
this Section 5(c). The Company shall take all action necessary to ensure that its Common Stock can be transferred electronically
as DWAC Shares.

 

(d)      Non-Public
Information. Except as provided under the License Agreement (including under Sections 4.3, 5.4 and 7.2 of the License Agreement),
the Company confirms that neither it nor any other Person acting on its behalf shall provide the Investor or its agents or counsel
with any information that constitutes or might constitute material, non-public information, unless a simultaneous public announcement
thereof is made by the Company in the manner contemplated by Regulation FD.

 

(e)      Taxes.
The Company shall pay any and all transfer, stamp or similar taxes that may be payable with respect to the issuance and delivery
of any shares of Common Stock to the Investor made under this Agreement.

 

(f)       Securities
Law Compliance. The Company shall comply with all applicable federal, state and foreign securities laws in connection with
the offer, issuance and sale by the Company of the Shares contemplated by the Transaction Documents. Without limiting the generality
of the foregoing, neither the Company nor any of its officers, directors or affiliates will take, directly or indirectly, any action
designed or intended to stabilize or manipulate the price of any security of the Company, or which would reasonably be expected
to cause or result in, stabilization or manipulation of the price of any security of the Company.

 

(g)      Integration.
From and after the date of this Agreement, neither the Company, nor any of its affiliates will, and the Company shall use its reasonable
best efforts to ensure that no Person acting on any of their behalf will, directly or indirectly, make any offers or sales of any
security or solicit any offers to buy any security, under circumstances that would cause this offering of the Shares to be integrated
with other offerings of securities by the Company in a manner that would require stockholder approval pursuant to the rules and
regulations of the Principal Market on which any of the securities of the Company are listed or designated, unless stockholder
approval is obtained before the closing of such subsequent transaction in accordance with the rules of such Principal Market.

 

(h)      Other
Transactions. The Company shall not enter into, announce or recommend to its stockholders any agreement, plan, arrangement
or transaction in or of which the terms thereof would restrict, materially delay, conflict with or impair the ability or right
of the Company to perform its obligations under any of the Transaction Documents to which it is a party, including, without limitation,
the obligation of the Company to deliver the Shares to the Investor in accordance with the terms of this Agreement.

 

    -12-

     

    

 

6.       TRANSFER
AGENT INSTRUCTIONS; TRANSFER RESTRICTIONS.

 

(a)      Transfer
Agent Instructions. On the Closing Date, the Company shall issue to the Transfer Agent (and any subsequent transfer agent)
instructions to issue the Shares in accordance with the terms of this Agreement (the “Irrevocable Transfer Agent Instructions”).
All Shares to be issued to or for the benefit of the Investor pursuant to this Agreement shall be issued to the Invest in book-entry
form and held in an account at the Transfer Agent. The Company represents and warrants to the Investor that no instruction other
than the Irrevocable Transfer Agent Instructions referred to in this Section 6 will be given by the Company to the Transfer Agent
with respect to the Shares. Certificates and any other instruments evidencing the Shares shall bear a restrictive legend pursuant
to Section 6(c).

 

(b)      Transfer
Restrictions. The Shares may only be disposed of in compliance with state and federal securities laws. In connection with any
transfer of the Shares other than pursuant to an effective registration statement or Rule 144 or to the Company, the Company may
require the Investor to provide to the Company an opinion of counsel selected by the Investor and reasonably acceptable to the
Company, the form and substance of which opinion shall be reasonably satisfactory to the Company, to the effect that such transfer
does not require registration of such transferred Shares under the Securities Act and, as a condition of such transfer, any such
transferee shall agree in writing to be bound by the terms of this Agreement and shall have the rights and obligations of the Investor
under this Agreement

 

(c)      Legend.
Each book-entry statement representing the Shares shall be stamped or otherwise imprinted with a legend substantially in the following
form (in addition to any legend required by applicable state securities or “blue sky” laws):

 

THE SECURITIES REPRESENTED
BY THIS BOOK-ENTRY STATEMENT (THE “SECURITIES”) HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE “SECURITIES ACT”) OR ANY STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF UNLESS
REGISTERED UNDER THE SECURITIES ACT AND UNDER APPLICABLE STATE SECURITIES LAWS OR AXSOME THERAPEUTICS, INC. SHALL HAVE RECEIVED
AN OPINION OF ITS COUNSEL THAT REGISTRATION OF SUCH SECURITIES UNDER THE SECURITIES ACT AND UNDER THE PROVISIONS OF APPLICABLE
STATE SECURITIES LAWS IS NOT REQUIRED.

 

The above legend may
only be removed by the Transfer Agent in accordance with Section 3(i) hereof.

 

    -13-

     

    

 

 7.       CLOSING CONDITIONS 

 

The obligation of the
parties to on the Closing Date shall be subject to the satisfaction or, where legally permissible, the waiver of each of the following
conditions:

 

(a)      The
Investor shall have executed each of the applicable Transaction Documents and delivered the same to the Company; and

 

(b)      The
representations and warranties of the Investor shall be true and correct in all material respects as of the date hereof and as
of the Closing Date as though made at that time.

 

(c)      The
Company shall have executed each of the applicable Transaction Documents and delivered the same to the Investor;

 

(d)      The
representations and warranties of the Company shall be true and correct in all material respects (except to the extent that any
of such representations and warranties is already qualified as to materiality in Section 4 above, in which case, the portion of
such representations and warranties so qualified shall be true and correct without further qualification) as of the date hereof
and as of the Closing Date as though made at that time (except for representations and warranties that speak as of a specific date,
which shall be true and correct as of such date) and the Company shall have performed, satisfied and complied in all material respects
with the covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with
by the Company at or prior to the Closing Date.

 

(e)      The Investor shall
have received a certificate, executed by the CEO, President or CFO of the Company, dated as of the Closing Date, to the foregoing
effect in the form attached hereto as Exhibit A;

 

(f)       The
Company shall have delivered to the Investor a secretary's certificate executed by the Secretary of the Company, dated as of the
Closing Date, in the form attached hereto as Exhibit B;

 

(g)      The
Company shall have issued the Irrevocable Transfer Instructions to the Transfer Agent;

 

(h)      All
federal, state and local governmental laws, rules and regulations applicable to the transactions contemplated by the Transaction
Documents and necessary for the execution, delivery and performance of the Transaction Documents and the consummation of the transactions
contemplated thereby in accordance with the terms thereof shall have been complied with, and all consents, authorizations and orders
of, and all filings and registrations with, all federal, state and local courts or governmental agencies and all federal, state
and local regulatory or self-regulatory agencies necessary for the execution, delivery and performance of the Transaction Documents
and the consummation of the transactions contemplated thereby in accordance with the terms thereof shall have been obtained or
made, including, without limitation, in each case those required under the Securities Act, the Exchange Act, applicable state securities
or “Blue Sky” laws or applicable rules and regulations of the Principal Market, or otherwise required by the SEC, the
Principal Market or any state securities regulators;

 

    -14-

     

    

 

(i)       No
statute, regulation, order, decree, writ, ruling or injunction shall have been enacted, entered, promulgated, threatened or endorsed
by any federal, state, local or foreign court or governmental authority of competent jurisdiction which prohibits the consummation
of or which would materially modify or delay any of the transactions contemplated by the Transaction Documents;

 

(j)       No
action, suit or proceeding before any federal, state, local or foreign arbitrator or any court or governmental authority of competent
jurisdiction shall have been commenced or threatened, and no inquiry or investigation by any federal, state, local or foreign governmental
authority of competent jurisdiction shall have been commenced or threatened, against the Company, or any of the officers, directors
or affiliates of the Company, seeking to restrain, prevent or change the transactions contemplated by the Transaction Documents,
or seeking material damages in connection with such transactions;

 

(k)      No
Person shall have commenced a proceeding against the Company pursuant to or within the meaning of any Bankruptcy Law;

 

(l)       The
Company, pursuant to or within the meaning of any Bankruptcy Law, shall not have (i) commenced a voluntary case, (ii) consented
to the entry of an order for relief against it in an involuntary case, (iii) consented to the appointment of a Custodian of it
or for all or substantially all of its property, or (iv) made a general assignment for the benefit of its creditors or is generally
unable to pay its debts as the same become due; and

 

(m)     A
court of competent jurisdiction shall not have entered an order or decree under any Bankruptcy Law that (i) is for relief against
the Company in an involuntary case, (ii) appoints a Custodian of the Company or for all or substantially all of its property, or
(iii) orders the liquidation of the Company or any Subsidiary.

 

8.        MISCELLANEOUS.

 

(a)       Governing
Law; Jurisdiction; Jury Trial. The corporate laws of the State of Delaware shall govern all issues concerning the relative
rights of the Company and its stockholders. All other questions concerning the construction, validity, enforcement and interpretation
of this Agreement and the other Transaction Documents shall be governed by the internal laws of the State of New York, without
giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions)
that would cause the application of the laws of any jurisdictions other than the State of Illinois. Each party hereby irrevocably
submits to the exclusive jurisdiction of the state court located in the State of New York in the Borough of Manhattan and federal
court located in the Southern District of the State of New York for the adjudication of any dispute hereunder or under the other
Transaction Documents or in connection herewith or therewith, or with any transaction contemplated hereby or discussed herein,
and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally
subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that
the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address
for such notices to it under this Agreement and the other Transaction Documents and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to
serve process in any manner permitted by law. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO
REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT
OR ANY OF THE OTHER TRANSACTION DOCUMENTS OR ANY TRANSACTION CONTEMPLATED HEREBY OR THEREBY.

 

    -15-

     

    

 

(b)      Counterparts.
This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the same agreement
and shall become effective when counterparts have been signed by each party and delivered to the other party; provided that a facsimile
signature or signature delivered by e-mail in a “.pdf” format data file shall be considered due execution and shall
be binding upon the signatory thereto with the same force and effect as if the signature were an original signature.

 

(c)      Headings.
The headings of this Agreement are for convenience of reference and shall not form part of, or affect the interpretation of, this
Agreement.

 

(d)      Severability.
If any provision of this Agreement shall be invalid or unenforceable in any jurisdiction, such invalidity or unenforceability shall
not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability
of any provision of this Agreement in any other jurisdiction.

 

(e)      Entire
Agreement; Amendment. This Agreement and the other Transaction Documents supersede all other prior oral or written agreements
among the Investor, the Company, their respective affiliates and Persons acting on their behalf with respect to the subject matter
hereof, and this Agreement, the other Transaction Documents and the instruments referenced herein contain the entire understanding
of the parties with respect to the matters covered herein and therein and, except as specifically set forth herein or therein,
neither the Company nor the Investor makes any representation, warranty, covenant or undertaking with respect to such matters.
The Company acknowledges and agrees that is has not relied on, in any manner whatsoever, any representations or statements, written
or oral, other than as expressly set forth in the Transaction Documents. No provision of this Agreement or the other Transaction
Documents may be amended other than by a written instrument signed by both parties hereto.

 

(f)       Notices.
Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must
be in writing and will be deemed to have been delivered: (i) upon receipt when delivered personally; (ii) upon receipt when sent
by facsimile or email (provided confirmation of transmission is mechanically or electronically generated and kept on file by the
sending party); or (iii) one Business Day after deposit with a nationally recognized overnight delivery service, in each case properly
addressed to the party to receive the same. The addresses for such communications shall be:

 

    -16-

     

    

 

 

	If to the Company:
	Axsome Therapeutics, Inc.
	200 Broadway, 3rd Floor
	New York, New York 10038
	Telephone:	(212) 332-3241
	Facsimile:	(212) 320-6270
	E-mail:	npizzie@axsome.com
	Attention:	Nick Pizzie, Chief Financial Officer
	 	 
	With a copy to (which shall not constitute notice or service of process):
	DLA Piper LLP (US)
	51 John F. Kennedy Parkway, Suite 120
	Short Hills, New Jersey 07078
	Telephone:	(973) 307-3004
	Facsimile:	(973) 520-2551
	E-mail:	emilio.ragosa@dlapiper.com
	Attention:	Emilio Ragosa, Esq.
	 	 
	If to the Investor:
	Pfizer Inc.
	235 East 42nd Street
	New York, NY 10017
	Attention: Vice President, Corporate Development
	 	 
	With a copy to (which shall not constitute notice or service of process):
	Pfizer Inc.235 East 42nd Street
	New York, NY 10017
	Attention: Andrew J. Muratore, Esq.
	Telephone: (212) 733-7965
	E-mail: andrew.j.muratore@pfizer.com
	 	 
	If to the Transfer Agent:
	American Stock Transfer & Trust Company, LLC
	6201 15th Avenue
	Brooklyn, NY 11219
	Telephone:	718.921.8300
	Facsimile:	718.765.8782
	Attention:	Jordan Hirsch

 

or at such other address and/or facsimile
number and/or to the attention of such other Person as the recipient party has specified by written notice given to each other
party three (3) Business Days prior to the effectiveness of such change. Written confirmation of receipt (A) given by the recipient
of such notice, consent, waiver or other communication, (B) mechanically or electronically generated by the sender's facsimile
machine or email account containing the time, date, and recipient facsimile number or email address, as applicable, and an image
of the first page of such transmission or (C) provided by a nationally recognized overnight delivery service, shall be rebuttable
evidence of personal service, receipt by facsimile or email or receipt from a nationally recognized overnight delivery service
in accordance with clause (i), (ii) or (iii) above, respectively.

 

    -17-

     

    

 

(g)       Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and any permitted successors and
assigns of the Company. The Company shall not assign this Agreement or any rights or obligations hereunder without the prior written
consent of the Investor, including by merger or consolidation. The Investor may not assign its rights or obligations under this
Agreement.

 

(h)       No
Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and any permitted successors and
assigns of the Company and is not for the benefit of, nor may any provision hereof be enforced by, any other Person.

 

(i)       Publicity.
The Company shall afford the Investor and its counsel with the opportunity to review and comment upon the form and substance of,
and shall give reasonable consideration to all such comments from the Investor or its counsel on, the Current Report and the Company’s
initial press release disclosing the Transaction Documents, if any, not less than one (1) business day prior to the issuance, filing
or public disclosure thereof. The Company agrees and acknowledges that its failure to fully comply with this provision constitutes
a Material Adverse Effect. Investor shall not issue a press release or any other public disclosure regarding this Agreement or
the substance hereof without the prior written consent of the Company, which consent shall not be unreasonably withheld, conditioned
or delayed.

 

(j)       Further
Assurances. Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall
execute and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably request
in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated
hereby.

 

(k)       No
Financial Advisor, Placement Agent, Broker or Finder. The Company represents and warrants to the Investor that it has not engaged
any financial advisor, placement agent, broker or finder in connection with the transactions contemplated hereby. The Investor
represents and warrants to the Company that it has not engaged any financial advisor, placement agent, broker or finder in connection
with the transactions contemplated hereby. The Company shall be responsible for the payment of any fees or commissions, if any,
of any financial advisor, placement agent, broker or finder relating to or arising out of the transactions contemplated hereby.
The Company shall pay, and hold the Investor harmless against, any liability, loss or expense (including, without limitation, reasonable
attorneys' fees and out of pocket expenses) arising in connection with any such claim.

 

(l)       No
Strict Construction. The language used in this Agreement will be deemed to be the language chosen by the parties to express
their mutual intent, and no rules of strict construction will be applied against any party.

 

    -18-

     

    

 

(m)       Remedies,
Other Obligations, Breaches and Injunctive Relief. The Investor’s remedies provided in this Agreement shall be cumulative
and in addition to all other remedies available to the Investor under this Agreement, at law or in equity (including a decree of
specific performance and/or other injunctive relief), no remedy of the Investor contained herein shall be deemed a waiver of compliance
with the provisions giving rise to such remedy and nothing herein shall limit the Investor's right to pursue actual damages for
any failure by the Company to comply with the terms of this Agreement. The Company acknowledges that a breach by it of its obligations
hereunder will cause irreparable harm to the Investor and that the remedy at law for any such breach may be inadequate. The Company
therefore agrees that, in the event of any such breach or threatened breach, the Investor shall be entitled, in addition to all
other available remedies, to an injunction restraining any breach, without the necessity of showing economic loss and without any
bond or other security being required.

 

(n)       Enforcement
Costs. If: (i) this Agreement is placed by the Investor in the hands of an attorney for enforcement or is enforced by the Investor
through any legal proceeding; (ii) an attorney is retained to represent the Investor in any bankruptcy, reorganization, receivership
or other proceedings affecting creditors' rights and involving a claim under this Agreement; or (iii) an attorney is retained to
represent the Investor in any other proceedings whatsoever in connection with this Agreement, then the Company shall pay to the
Investor, as incurred by the Investor, all reasonable costs and expenses including reasonable attorneys' fees incurred in connection
therewith, in addition to all other amounts due hereunder. If this Agreement is placed by the Company in the hands of an attorney
for enforcement or is enforced by the Company through any legal proceeding, then the Investor shall pay to the Company, as incurred
by the Company, all reasonable costs and expenses including reasonable attorneys’ fees incurred in connection therewith,
in addition to all other amounts due hereunder.

 

(o)       Waivers.
No provision of this Agreement may be waived other than in a written instrument signed by the party against whom enforcement of
such waiver is sought. No failure or delay in the exercise of any power, right or privilege hereunder shall operate as a waiver
thereof, nor shall any single or partial exercise of any such power, right or privilege preclude other or further exercise thereof
or of any other right, power or privilege.

 

 

[SIGNATURE PAGE FOLLOWS]

    -19-

     

    

 

IN WITNESS WHEREOF,
the Investor and the Company have caused this Agreement to be duly executed as of the date first written above.

 

	 	THE
    COMPANY:
	 	 
	 	AXSOME THERAPEUTICS,
    INC.
	 	   
	 	By:	/s/ Herriot Tabuteau, M.D.
	 	Name: 	Herriot Tabuteau, M.D.
	 	Title: 	Chief Executive Officer
	      	 
	 	INVESTOR:
	 	 
	 	PFIZER INC.
	 	 
	 	By:	/s/ Douglas Giordano
	 	Name: 	Douglas Giordano
	 	Title: 	Senior Vice President

 

    -20-

     

    

 

EXHIBITS

 

	Exhibit A	Form of Officer’s Certificate
	Exhibit B	Form of Secretary’s Certificate
	Exhibit C	Lock Up Provisions
	Exhibit D	Opinion of DLA Piper LLP

 

    

     

    

 

EXHIBIT A

 

FORM OF OFFICER’S CERTIFICATE

 

This Officer’s
Certificate (“Certificate”) is being delivered pursuant to Section 7(e) of that certain Share Transfer Agreement
dated as of January 10, 2020, (the “Agreement”), by and between AXSOME THERAPEUTICS, INC., a Delaware
corporation (the “Company”), and PFIZER INC. (the “Investor”). Terms used herein and
not otherwise defined shall have the meanings ascribed to them in the Agreement.

 

The undersigned, Nick
Pizzie, Chief Financial Officer of the Company, hereby certifies, on behalf of the Company and not in his individual capacity,
as follows:

 

1.       I
am the Chief Financial Officer of the Company and make the statements contained in this Certificate;

 

2.       The
representations and warranties of the Company are true and correct in all material respects (except to the extent that any of such
representations and warranties is already qualified as to materiality in Section 4 of the Purchase Agreement, in which case, such
representations and warranties are true and correct without further qualification) as of the date when made and as of the Closing
Date as though made at that time (except for representations and warranties that speak as of a specific date, in which case such
representations and warranties are true and correct as of such date);

 

3.       The
Company has performed, satisfied and complied in all material respects with covenants, agreements and conditions required by the
Transaction Documents to be performed, satisfied or complied with by the Company at or prior to the Closing Date.

 

4.       The Company
has not taken any steps, and does not currently expect to take any steps, to seek protection pursuant to any Bankruptcy Law nor
does the Company or any of its Subsidiaries have any knowledge or reason to believe that its creditors intend to initiate involuntary
bankruptcy or insolvency proceedings. The Company is financially solvent and is generally able to pay its debts as they become
due.

 

IN WITNESS WHEREOF,
I have hereunder signed my name on this ____ day of ________ __, 2020.

 

	 	 	 
	 	Name: 	Nick Pizzie
	 	Title: 	Chief Financial Officer

 

The undersigned as
Secretary of AXSOME THERAPEUTICS, INC., a Delaware corporation, hereby certifies that Nick Pizzie is the duly elected, appointed,
qualified and acting Chief Financial Officer of the Company and that the signature appearing above is his genuine signature.

 

	 	 
	 	Name:	Mark Jacobson
	 	Title:	Secretary

 

    

     

    

 

EXHIBIT B

 

FORM OF SECRETARY’S
CERTIFICATE

 

This Secretary’s
Certificate (“Certificate”) is being delivered pursuant to Section 7(e) of that certain Share Transfer Agreement dated
as of January 10, 2020 (“Agreement”), by and between AXSOME THERAPEUTICS, INC., a Delaware corporation
(the “Company”), PFIZER INC. (the “Investor”), pursuant to which the Company will
issue to the Investor 82,019 shares (the “Shares”) of the Company's common stock, $0.0001 par value per share
(the “Common Stock”). Terms used herein and not otherwise defined shall have the meanings ascribed to them in
the Agreement.

 

The undersigned, _____________, Secretary
of the Company, hereby certifies, on behalf of the Company and not in his individual capacity, as follows:

 

1.       I
am the Secretary of the Company and make the statements contained in this Secretary’s Certificate.

 

2.       Attached
hereto as Exhibit A and Exhibit B are true, correct and complete copies of the Company’s bylaws (“Bylaws”)
and Certificate of Incorporation (“Charter”), in each case, as amended or restated through the date hereof, and no
action has been taken by the Company, its directors, officers or stockholders, in contemplation of the filing of any further amendment
relating to or affecting the Bylaws or Charter.

 

3.       Attached
hereto as Exhibit C are true, correct and complete copies of the resolutions duly adopted by the Board of Directors of the
Company (or a duly authorized committee thereof) by unanimous written consent on January 4, 2020. Such resolutions have not been
materially amended, modified or rescinded and remain in full force and effect and such resolutions are the only resolutions adopted
by the Company’s Board of Directors (or a duly authorized committee thereof) or the stockholders of the Company relating
to or affecting (i) the entering into and performance of the Purchase Agreement, or the issuance, offering and sale of the Shares
and (ii) and the performance of the Company of its obligation under the Transaction Documents as contemplated therein.

 

IN WITNESS WHEREOF,
I have hereunder signed my name on this ___ day of ____________.

 

	 	 
	 	Name:	Mark Jacobson
	 	Title:	Secretary

 

 

The undersigned as
Chief Financial Officer of AXSOME THERAPEUTICS, INC., a Delaware corporation, hereby certifies that Mark Jacobson is the
duly elected, appointed, qualified and acting Secretary of the Company and that the signature appearing above is his genuine signature.

 

	 	 
	 	Name:	Nick Pizzie
	 	Title:	Chief Financial Officer

 

    

     

    

 

EXHIBIT C

 

LOCK UP PROVISIONS

 

In recognition of
the benefits conferred upon the undersigned, and for good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, Pfizer Inc. (the “Investor”), in connection with that certain Share Transfer Agreement, dated
as of January 4, 2020 (the “Agreement”), by and between the Investor and Axsome Therapeutics, Inc., a Delaware corporation
(the “Company”), hereby agrees that from the Closing Date of the Agreement and until 12 months thereafter (the “Lock
Up Period”), the Investor will not offer, sell, contract to sell, pledge or otherwise dispose of, directly or indirectly,
any Shares acquired pursuant to the Agreement (the “Lock Up Shares”). Notwithstanding the foregoing, the Lock Up Period
shall expire upon the consummation of a Change in Control transaction (as defined below). Except for the Lock Up Shares, any shares
of Common Stock or other securities convertible into or exchangeable or exercisable for any shares of Common Stock acquired by
the undersigned after the Closing Date in the open market or otherwise will not be subject to these provisions. All terms not otherwise
defined herein shall have the meaning accorded to them in the Agreement.

 

Nothing in these provisions
shall prohibit (i) the transfer of Lock Up Shares to any Affiliate (as defined below) of the Investor, provided that such transferee
agrees to be bound by the Agreement (including these provisions); or (ii) the Investor from engaging in any hedging transactions
or from otherwise hedging directly or indirectly its economic exposure with respect to any portion or all of the Lock Up Shares.
As used herein, “Affiliate” means any Person that directly or indirectly controls, is controlled by, or is under common
control with, the Investor. For the purpose hereof the term “control” means the holding of shares in excess of fifty
(50%) of the voting securities of a corporate entity.

 

In furtherance of
the foregoing, the Company and its transfer agent and registrar are hereby authorized to decline to make any transfer of Lock Up
Shares if such transfer would constitute a violation or breach of these provisions. Notwithstanding the foregoing, the Company
may, at the request of the undersigned upon ten (10) days written notice to the Company, waive the Lock Up Period.

 

As used herein, “Change
in Control” shall mean the occurrence of either of the following events to which the Company is a party: (i) a merger or
consolidation in which securities possessing more than fifty percent (50%) of the total combined voting power of the Company’s
outstanding securities are transferred to a person or persons different from the persons holding those securities immediately prior
to such transaction; or (ii) the sale, transfer or other disposition of all or substantially all of the Company’s assets
in complete liquidation or dissolution of the Company.

 

All
authority herein conferred or agreed to be conferred and any obligations of the Investor shall be binding upon the successors,
assigns, heirs or personal representatives of the Investor.

 

The investor understands
that the Company is entering into the Purchase Agreement and intends to enter into the License Agreement in reliance upon these
provisions.

 

    

     

    

 

EXHIBIT D

 

OPINION OF DLA PIPER LLP

 

See Attached.

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