Document:

exv10w15

Exhibit 10.15

EMPLOYMENT AGREEMENT

     THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into as of July 8, 2010,
by and between NuPathe Inc. (the “Employer”), a Delaware corporation, and Jane H. Hollingsworth
(the “Employee”), but is effective as of the effective date of the registration statement relating
to the Employer’s initial public offering (the “Effective Date”).

Recitals

     WHEREAS, the Employer and the Employee previously entered into that certain Third Amended and
Restated Employment Agreement dated January 1, 2010 (the “Prior Agreement”); and

     WHEREAS, the Employer and the Employee desire to amend the Prior Agreement in various
respects; and

     WHEREAS, Section 12 of the Prior Agreement permits the Employer and the Employee to amend the
Prior Agreement pursuant to a written agreement executed by both parties; and

     WHEREAS, the Employer desires to continue to employ the Employee and the Employee desires to
continue to be employed by the Employer upon the terms and conditions hereinafter set forth.

     NOW, THEREFORE, in consideration of the premises and covenants set forth herein, and
intending to be legally bound hereby, the parties to this Agreement hereby agree as follows:

     1. Duties. The Employer agrees that the Employee shall continue to serve as the Chief
Executive Officer of the Employer. The Employee shall report to the Board of Directors of the
Employer (the “Board”). The Employee agrees to be so employed by the Employer and to devote her
best efforts and substantially all of her business time to advance the interests of the Employer
and to perform such executive, managerial, administrative and financial functions as are required
to develop the Employer’s business and to perform other duties assigned to the Employee by the
Board that are consistent with the Employee’s position. Nothing set forth herein shall prohibit
the Employee from engaging in personal investing activities. The Employee shall be permitted to
serve on the boards of directors of other entities whose businesses are not competitive with the
Employer in accordance with Employer policy.

     2. Term. This Agreement is effective as of the Effective Date, and, from and after the
Effective Date, will govern the Employee’s employment by the Employer until that employment ceases
in accordance with the terms of this Agreement.

     3. Compensation.

          (a) Salary. The Employee shall be paid a base salary at the annual rate of $370,000 (the
“Base Salary”) in accordance with the Employer’s regular payroll practices. The Board or the
Compensation Committee of the Board (the “Compensation Committee”) shall review the Base Salary for
appropriate increases at least annually at the end of each calendar year pursuant to the normal
performance review policies for senior level executives.

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          (b) Incentive Compensation. The Employee shall participate in short-term and long-term
incentive programs, including equity compensation programs, established by the Employer for its
senior level executives generally, at levels determined by the Board or the Compensation Committee.
The Employee’s incentive compensation shall be subject to the terms of the applicable plans and
shall be determined based on the Employee’s individual performance and Employer performance as
determined by the Board or the Compensation Committee. Any annual incentive compensation earned by
the Employee shall be paid on or after January 1, but not later than March 15 of the fiscal year
following the fiscal year for which the annual incentive compensation is earned.

          (c) Retirement and Welfare Benefits. The Employee shall participate in employee retirement
and welfare benefit plans made available to the Employer’s senior level executives as a group or to
its employees generally, as such retirement and welfare plans may be in effect from time to time
and subject to the eligibility requirements of the plans. Nothing in this Agreement shall prevent
the Employer from amending or terminating any retirement, welfare or other employee benefit plans
or programs from time to time as the Employer deems appropriate.

          (d) Reimbursement of Expenses; Vacation. The Employee shall be reimbursed for all normal
items of travel, entertainment and miscellaneous business expenses reasonably incurred by the
Employee on behalf of the Employer, provided that such expenses are documented and submitted in
accordance with the reimbursement policies of the Employer as in effect from time to time. The
Employee shall be entitled to vacation and sick leave in accordance with the Employer’s vacation,
holidays and other pay for time not worked policies

     4. Termination.

          (a) Death. This Agreement shall automatically terminate effective as of the date of the
Employee’s death, in which event the Employer shall have no further obligation or liability under
this Agreement except that the Employer shall pay to the Employee’s estate: (i) any portion of the
Employee’s Base Salary for the period up to the Employee’s date of death that has been earned but
remains unpaid; and (ii) any benefits that have been earned, accrued and are due to the Employee
under the terms of the employee benefit plans of the Employer, which benefits shall be paid in
accordance with the terms of those plans; and (iii) the amount of the Earned Bonus as defined
herein. The Earned Bonus shall be paid at the same time bonuses are paid to employees of the
Employer generally in accordance with the terms of the Employer’s annual bonus plan.

          (b) Total Disability. In the event of the Employee’s Total Disability (as defined below), the
Employer may terminate the employment of the Employee, to the extent permitted by law, immediately
upon written notice to the Employee, in which event, the Employer shall have no further obligation
or liability under this Agreement except that the Employer shall pay to the Employee: (i) any
portion of the Employee’s Base Salary for the period up to the date of termination that has been
earned but remains unpaid; (ii) any benefits that have been earned, accrued and are due to the
Employee under the terms of the employee benefit plans of the Employer, which benefits shall be
paid in accordance with the terms of those plans; and (iii) the amount of the Earned Bonus as
defined herein. The Earned Bonus shall be

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paid at the same time bonuses are paid to employees of
the Employer generally in accordance with the terms of the Employer’s annual bonus plan.

          (c) Termination by the Employer for Cause. Subject to any applicable right to cure under
Section 4(f)(i), the Employer may terminate the Employee’s employment at any time, effective
immediately, for Cause upon written notice to the Employee. In the event that the Employer
terminates the Employee pursuant to this Section 4(c), the Employer shall have no further
obligation or liability under this Agreement, except that the Employer shall pay to the Employee:
(i) any portion of the Employee’s Base Salary for the period up to the Termination Date that has
been earned but remains unpaid; and (ii) any benefits that have been earned, accrued and are due to
the Employee under the terms of the employee benefit plans of the Employer, which benefits shall be
paid in accordance with the terms of those plans.

          (d) Termination by the Employer Without Cause; Termination by the Employee for Good Reason.
The Employer may terminate the employment of the Employee for any reason other than those specified
in Section 4(b) or 4(c), including, without limitation, on or after a Change of Control, upon
thirty (30) days written notice (or Base Salary and benefit continuation in lieu of such thirty
(30) day notice) to the Employee. In addition, the Employee may terminate her employment at any
time, including, without limitation, on or after a Change of Control, upon written notice to the
Employer for Good Reason in accordance with the requirements of Section 4(e)(v).

In the event the Employer terminates the employment of the Employee for any reason other than those
specified in Section 4(b) or 4(c) hereof or the Employee terminates her employment for Good Reason,
the Employer shall pay to the Employee:

          (i) any portion of the Employee’s Base Salary for the period up to the Termination Date that
has been earned but remains unpaid;

          (ii) any benefits that have been earned, accrued and are due to the Employee under the terms
of any employee benefit plans of the Employer, which benefits shall be paid in accordance with the
terms of those plans; and

          (iii) subject to the execution and nonrevocation by the Employee of a release satisfactory to
the Employer and on reasonable, market level terms (the “Release”) and the Employee’s compliance
with all terms and provisions of this Agreement that survive the termination of the Employee’s
employment by the Employer, the Employer shall provide the Employee with the payments and benefits
set forth below. Notwithstanding any provision of this Agreement to the contrary, in no event
shall the timing of the Employee’s execution of the Release, directly or indirectly result in the
Employee designating the calendar year of payment and to the extent payment could be made in more
than one taxable year, payment shall be made in the later taxable year.

               (A) Severance in an amount equal to 1.5 times the Employee’s Base Salary at the rate in effect
at the time of the Employee’s termination. The severance amount shall be paid in equal monthly
installments in accordance with the Employer’s regular payroll

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practices over a period of eighteen
(18) months, beginning within sixty (60) days following the Termination Date;

               (B) the amount of the Earned Bonus which shall be paid at the same time bonuses are paid to
employees of the Employer generally in accordance with the terms of the Employer’s annual bonus
plan;

               (C) continued medical and dental coverage at the same level in effect at the Termination Date
(or generally comparable coverage) for a period of eighteen (18) months following the Termination
Date for herself and, where applicable, her spouse and dependents, at the same premium rates as may
be charged from time to time for employees generally, as if the Employee had continued in
employment during such eighteen (18) month period. The COBRA health care continuation period shall
run concurrently with the foregoing eighteen (18) month period; and

               (D) vesting of all outstanding unvested stock options and other equity-based awards held by
the Employee as of the Termination Date that would have vested had the Employee remained employed
until the end of the calendar quarter in which the Termination Date occurs; provided, further, that
any outstanding unvested stock option or other equity-based award that vests based upon attainment
of performance criteria (each, a “Performance Award”) shall vest upon termination of the Employee’s
employment in accordance with the terms of the award agreement evidencing such Performance Award.

          (e) Effect of a Change of Control. Notwithstanding any provision of Section 4(d) to the
contrary, if the Employee’s employment is terminated pursuant to Section 4(d) within the ninety
(90) day period preceding a Change of Control or on or within twelve (12) months following a Change
of Control, the Employee shall be entitled to the same payments and benefits described in Section
4(d) above, subject to execution and nonrevocation of the Release and the Employee’s compliance
with all terms and provisions of this Agreement that survive the termination of the Employee’s
employment by the Employer; provided that (i) the severance multiplier in Section 4(d)(iv)(A) above
shall be 1.5 times the Employee’s Base Salary at the rate in effect at the time of the Employee’s
termination plus 1.5 times the Employee’s targeted annual bonus for the year in which the
Termination Date occurs, without regard to whether the relevant Employee and Employer goals have
been achieved, (ii) the period of continued medical and dental coverage in Section 4(d)(iv)(B)
above shall be eighteen (18) months following the Termination Date and (iii) one hundred percent
(100%) of all outstanding unvested stock options and other equity-based awards held by the Employee
as of the Termination Date shall become fully vested and exercisable (to the extent applicable) as
of the Termination Date; provided, further, that any Performance Award shall vest upon termination
of the Employee’s employment in accordance with the terms of the award agreement evidencing such
Performance Award.

          Notwithstanding anything set forth in this Agreement to the contrary, if any payment or
benefit, including severance benefits, that the Employee would receive from the Employer in
connection with a Change of Control or otherwise (“Payment”) would (i) constitute a “parachute
payment” within the meaning of section 280G of the Code and (ii) but for this sentence, be subject
to the excise tax imposed by section 4999 of the Code (the “Excise Tax”), then such Payment shall
be reduced to the Reduced Amount. The “Reduced Amount” shall be

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either (A) the largest portion of
the Payment that would result in no portion of the Payment being subject to the Excise Tax or (B)
the largest portion, up to and including the total, of the Payment, whichever amount, after taking
into account all applicable federal, state and local employment taxes, income taxes, and the Excise
Tax (all computed at the highest applicable marginal rate), results in the Employee’s receipt, on
an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion
of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits (or a
cancellation of the acceleration of vesting of stock options or equity awards) constituting
“parachute payments” is necessary so that the Payment equals the Reduced Amount, such reduction
and/or cancellation of acceleration shall occur in the order that provides the maximum economic
benefit to the Employee. In the event that acceleration of vesting of a stock option or equity
award is to be reduced, such acceleration of vesting also shall be canceled in the order that
provides the maximum economic benefit to the Employee.

          The Employer shall appoint a nationally recognized accounting firm with appropriate subject
matter expertise to make the determinations required under this Section 4(e).

          The Employer shall bear all expenses with respect to the making of the determinations by such
accounting firm required to be made under this Section 4(e). The accounting firm engaged to make
the determinations under this Section 4(e) shall provide its calculations, together with detailed
supporting documentation, to the Employer and the Employee as soon as practicable after the date on
which the Employee’s right to a Payment is triggered (if requested at that time by the Employer or
the Employee) or such other time as requested by the Employer or the Employee. If the accounting
firm determines that no Excise Tax is payable with respect to a Payment, either before or after the
application of the Reduced Amount, it shall furnish the Employer with an opinion reasonably
acceptable to the Employee that no Excise Tax will be imposed with respect to such Payment. Any
good faith determinations of the accounting firm made under this Section 4(e) shall be final,
binding, and conclusive upon the Employer and the Employee.

          (f) Definitions.

	 	(i)	 	“Cause” shall be deemed to exist with respect
to any termination of employment by the Employer for any of the
following reasons:

	 	(1)	 	the Employee’s engagement in
conduct constituting breach of fiduciary duty, gross negligence
or willful misconduct relating to the Employer or the
performance of the Employee’s duties; provided that no act or
failure to act shall be deemed “willful” unless done, or omitted
to be done, by the Employee not in good faith or without
reasonable belief that the Employee’s action or omission was in
the best interest of the Employer;
	 
	 	(2)	 	the Employee’s substantial and
continued failure to perform the Employee’s material duties in a
satisfactory manner after written notice specifying the areas in
which

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	 	 	 	performance is unsatisfactory and, if subject to cure, the
Employee’s failure to perform within thirty (30) days after such
notice;
	 
	 	(3)	 	the Employee’s commission of any
act of fraud with respect to the Employer;
	 
	 	(4)	 	the Employee’s violation of any
covenants or agreements in favor of the Employer regarding
confidentiality, non-competition and/or non-solicitation; or
	 
	 	(5)	 	the Employee’s conviction of a
felony or a crime involving moral turpitude under the laws of
the United States or any state or political subdivision thereof.

	 	 	 	Any notice required to be provided to the Employee under clause (2)
of this definition of “Cause” shall state that failure to
cure within the applicable period will result in termination for
Cause.
	 
	 	(ii)	 	“Change of Control” shall have the same
meaning ascribed to such term under the Employer’s 2010 Omnibus Equity
Compensation Plan, as in effect on the date hereof and as it may be
amended from time to time.
	 
	 	(iii)	 	“Code” shall mean the Internal Revenue Code of
1986, as amended, and the regulations promulgated thereunder.
	 
	 	(iv)	 	“Earned Bonus” means the actual annual bonus
earned by the Employee for the fiscal year in which the Employee’s
Termination Date occurs; pro rated to reflect the portion of the fiscal
year during which the Employee was employed by the Employer, determined
by multiplying the full year bonus that would otherwise have been
payable to the Employee based upon the achievement of applicable
performance objectives by a fraction, the numerator of which is the
number of days during which the Employee was employed by the Employer
in the year of termination and the denominator of which is three
hundred sixty-five (365).
	 
	 	(v)	 	“Good Reason” shall be deemed to exist with
respect to any termination of employment by the Employee for any of the
following reasons:

	 	(1)	 	prior to a Change of Control, a
material reduction in the Employee’s duties and
responsibilities, which for purposes of this Agreement means the
assignment to Employee of any duties or responsibilities which
are materially inconsistent with or adverse to the Employee’s
then current

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	 	 	 	duties, responsibilities, positions and/or titles
with the Employer;
	 
	 	(2)	 	on or after a Change of Control,
a material reduction in the Employee’s duties and
responsibilities, which for purposes of this Agreement means the
failure of the Employer or its successors, without the
Employee’s consent, to maintain the Employee in an executive
officer position with duties and responsibilities consistent
with that of an executive officer;
	 
	 	(3)	 	a material reduction of the
Employee’s then-current base salary or target bonus opportunity;
	 
	 	(4)	 	the requirement that the Employee
regularly report to work at a location that is more than fifty
(50) miles from the location of the Employee’s employment as of
the Effective Date;
	 
	 	(5)	 	a material breach of this
Agreement by the Employer; or
	 
	 	(6)	 	in the event of the assignment of
this Agreement to a third party, the failure of the assignee or
successor entity to agree to be bound to the terms of this
Agreement;

	 	 	 	provided, however, that for any of the foregoing to
constitute Good Reason, the Employee must provide written
notification of her intention to resign within ninety (90) days after
the Employee first knows or first has reason to know of the
occurrence of any such event or condition, and, the Employer must
have thirty (30) business days from the date of receipt of such
notice to effect a cure of the event or condition constituting Good
Reason. If the Employer fails to effect a cure of the event or
condition constituting Good Reason, the Employee must actually resign
from employment within thirty (30) days following the expiration of
the foregoing cure period. In the event of a cure of such event or
condition constituting Good Reason by the Employer, such event or
condition shall no longer constitute Good Reason.
	 
	 	(vi)	 	“Termination Date” shall mean the date on which
the Employee’s employment with the Employer terminates in accordance
with the applicable provisions of this Agreement.
	 
	 	(vii)	 	“Total Disability,” shall mean an illness,
incapacity or a mental or physical condition that renders the Employee
unable, despite the provision, if requested, of a reasonable
accommodation as that term is defined in the Americans with
Disabilities Act, to perform

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	 	 	 	the essential functions of her employment
position for a continuous period of six (6) months or more.

          (g) No Mitigation. The Employee shall not be required to mitigate the amount of any payment
provided for in this Section 4 by seeking other employment or otherwise, nor shall the amount of
any payment or benefit provided for in this Section 4 be reduced by any compensation earned by the
Employee as the result of employment by another employer or self-employment, by retirement
benefits, by offset against any amounts (other than loans or advances to the Employee by the
Employer) claimed to be owed by the Employee to the Employer, or otherwise.

     5. Non-Disclosure; Non-Competition and Prior Agreements.

          (a) Non-Disclosure. The Employee acknowledges that in the course of performing services for
the Employer, the Employee will obtain knowledge of the Employer’s business plans, products,
processes, software, know-how, trade secrets, formulas, methods, models, prototypes, discoveries,
inventions, improvements, disclosures, names and positions of employees and/or other proprietary
and/or confidential information (collectively the “Confidential Information”). The Employee agrees
to keep the Confidential Information secret and confidential and not to publish, disclose or
divulge to any other party, and the Employee agrees not to use any of the Confidential Information
for the Employee’s own benefit or to the detriment of the Employer without the prior written
consent of the Employer, whether or not such Confidential Information was discovered or developed
by the Employee. The Employee also agrees not to divulge, publish or use any proprietary and/or
confidential information of others that the Employer is obligated to maintain in confidence.

          (b) Non-Competition. The Employee agrees that, during her employment by the Employer
hereunder and for an additional period of eighteen (18) months after the termination of the
Employee’s employment hereunder for any reason, neither the Employee nor any corporation or other
entity in which the Employee may be interested as a partner, trustee, director, officer, employee,
agent, shareholder, lender of money or guarantor, or for which he performs services in any capacity
(including as a consultant or independent contractor) shall at any time during such period be
engaged, directly or indirectly, in any Competitive Business (as that term is hereinafter defined).
The Employee shall not solicit or, if the Employee owns or has the right to acquire more than five
percent (5%) of the fully-diluted equity of the employing entity or its affiliates, hire, directly
or indirectly, any person that was employed by Employer during the six (6) month period immediately
preceding the Employee’s termination of employment with the Employer. For purposes of this Section
5(b) the term “Competitive Business” shall mean any job, role, or specific responsibilities within
a firm, company, or business organization that competes directly with the Employer’s business as in
effect at the time of the Employee’s termination of employment with the Employer or in a business
area planned in writing by the Employer before the Termination Date for entry within twelve (12)
months of the Termination Date at the time of the Employee’s termination of employment with the
Employer. The foregoing prohibition shall not prevent any employment or engagement of the
Employee, after termination of employment with the Employer, by any firm, company, or business
organization engaged in a Competitive Business as long as the activities of any such employment or
engagement, in any capacity, do not involve work on matters related to any

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business, product or
service being developed, manufactured, marketed, distributed or planned in writing by the Employer
at the time of the Employee’s termination of employment with the Employer. The Employee’s
ownership of no more than one percent (1%) of the outstanding voting stock of a publicly traded
company shall not constitute a violation of this Section 5(b). The Employee is entering into this
covenant not to compete in consideration of the agreements of the Employer in this Agreement,
including but not limited to, the agreement of the Employer to pay severance to the Employee upon a
termination of employment pursuant to Section 4(d) hereof and the agreement of the Employer to
accelerate the vesting of the Employee’s stock options and other equity-based awards upon a Change
of Control in accordance with the terms of Section 4(d).

          (c) Prior Agreements. The Employee represents and warrants to the Employer that there are no
restrictions, agreements or understandings whatsoever to which the Employee is a party that would
prevent or make unlawful the Employee’s execution of this Agreement or the Employee’s employment
hereunder, is or would be inconsistent or in conflict with this Agreement or the Employee’s
employment hereunder, or would prevent, limit or impair in any way the performance by the Employee
of the obligations hereunder.

     6. Inventions and Discoveries.

          (a) Disclosure. The Employee shall promptly and fully disclose to the Employer, with all
necessary detail, all developments, know-how, discoveries, inventions, improvements, concepts,
ideas, formulae, processes and methods (whether copyrightable, patentable or otherwise) made,
received, conceived, acquired or written by the Employee (whether or not at the request or upon the
suggestion of the Employer, solely or jointly with others), during the period of her employment
with the Employer that (i) result from, arise out of, or relate to any work, assignment or task
performed by the Employee on behalf of the Employer, whether undertaken voluntarily or assigned to
the Employee within the scope of her responsibilities to the Employer, or (ii) were developed
using the Employer’s facilities or other resources or in Employer time, or (iii) result from the
Employee’s use or knowledge of the Employer’s Confidential Information, or (iv) relate to the
Employer’s business or any of the products or services being developed, manufactured or sold by the
Employer or that may be used in relation therewith (collectively referred to as “Inventions”). The
Employee hereby acknowledges that all original works of authorship that are made by the Employee
(solely or jointly with others) within the above terms and that are protectable by copyright are
“works made for hire,” as that term is defined in the United States Copyright Act. The Employee
understands and hereby agrees that the decision whether or not to commercialize or market any
Invention developed by the Employee solely or jointly with others is within the Employer’s sole
discretion and for the Employer’s sole benefit and that no royalty shall be due to the Employee as
a result of the Employer’s efforts to commercialize or market any such Invention.

          (b) Assignment and Transfer. The Employee agrees to assign and transfer to the Employer all
of the Employee’s right, title and interest in and to the Inventions, and the Employee further
agrees to deliver to the Employer any and all drawings, notes, specifications and data relating to
the Inventions, and to sign, acknowledge and deliver all such further papers, including
applications for and assignments of copyrights and patents, and all renewals thereof, as may be
necessary to obtain copyrights and patents for any Inventions in any and all countries and

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to vest
title thereto in the Employer and its successors and assigns and to otherwise protect the
Employer’s interests therein. The Employee shall not charge the Employer for time spent in
complying with these obligations. If the Employer is unable because of the Employee’s mental or
physical incapacity or for any other reason to secure the Employee’s signature to apply for or to
pursue any application for any United States or foreign patents or copyright registrations covering
Inventions or original works of authorship assigned to the Employer as above, then the Employee
hereby irrevocably designates and appoints the Employer and its duly authorized officers and agents
as the Employee’s agent and attorney in fact, to act for and in the Employee’s behalf and stead to
execute and file any such applications and to do all other lawfully permitted acts to further the
prosecution and issuance of letters patent or copyright registrations thereon with the same legal
force and effect as if executed by the Employee.

          (c) Records. The Employee agrees that in connection with any research, development or other
services performed for the Employer, the Employee will maintain careful, adequate and
contemporaneous written records of all Inventions, which records shall be the property of the
Employer.

     7. Employer Documentation. The Employee shall hold in a fiduciary capacity for the benefit of
the Employer all documentation, disks, programs, data, records, drawings, manuals, reports,
sketches, blueprints, letters, notes, notebooks and all other writings, electronic data, graphics
and tangible information and materials of a secret, confidential or proprietary information nature
relating to the Employer or the Employer’s business that are in the possession or under the control
of the Employee.

     8. Injunctive Relief. The Employee acknowledges that her compliance with the agreements in
Sections 5, 6, and 7 hereof is necessary to protect the good will and other proprietary interests
of the Employer and that she is one of the principal executives of the Employer and conversant with
its affairs, its trade secrets and other proprietary information. The Employee acknowledges that a
breach of any of her agreements in Sections 5, 6 and 7 hereof will result in irreparable and
continuing damage to the Employer for which there will be no adequate remedy at law; and the
Employee agrees that in the event of any breach of the aforesaid agreements, the Employer and its
successors and assigns shall be entitled to injunctive relief and to such other and further relief
as may be proper.

     9. Application of Section 409A of the Internal Revenue Code.

          (a) Compliance. This Agreement shall be interpreted to avoid any penalty sanctions under
section 409A of the Code. If any payment or benefit cannot be provided or made at the time
specified herein without incurring sanctions under section 409A of the Code, then such benefit or
payment shall be provided in full at the earliest time thereafter when such sanctions will not be
imposed. For purposes of section 409A of the Code, all payments to be made upon a termination of
employment under this Agreement may only be made upon a “separation from service” under section
409A of the Code, each payment made under this Agreement shall be treated as a separate payment,
and the right to a series of installment payments under this Agreement is to be treated as a right
to a series of separate payments. In no event shall the Employee, directly or indirectly,
designate the calendar year of payment. All reimbursements provided under this Agreement shall be
made or provided in accordance with

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the requirements of section 409A of the Code, including, where
applicable, the requirement that (i) any reimbursement is for expenses incurred during the
Employee’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the
amount of expenses eligible for reimbursement during a calendar year may not affect the expenses
eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible
expense will be made on or before the last day of the calendar year following the year in which the
expense is incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange
for another benefit.

          (b) Payment Delay. Notwithstanding any provision in this Agreement to the contrary, if at
the time of the Employee’s termination of employment with the Employer, the Employer has securities
which are publicly-traded on an established securities market and the Employee is a “specified
employee” (as defined in section 409A of the Code) and it is necessary to postpone the commencement
of any severance payments otherwise payable pursuant to this Agreement as a result of such
termination of employment in order to prevent any accelerated or additional tax under section 409A
of the Code, then the Employer shall postpone the commencement of the payment of any such payments
or benefits hereunder (without any reduction in such payments or benefits ultimately paid or
provided to the Employee) that are not otherwise paid within the short-term deferral exception
under section 409A of the Code and are in excess of the lesser of two (2) times (i) the Employee’s
then-annual compensation or (ii) the limit on compensation then set forth in section 401(a)(17) of
the Code, until the first payroll date that occurs after the date that is six (6) months following
the Employee’s “separation from service” with the Employer (as defined under section 409A of the
Code). If any payments are postponed due to such requirements, such postponed amounts shall be
paid in a lump sum to the Employee, and any installment payments due to the Employee shall
recommence, on the first payroll date that occurs after the date that is six (6) months following
the Employee’s “separation from service” with the Employer. If the Employee dies during the
postponement period prior to the payment of the postponed amount, the amounts withheld on account
of section 409A of the Code shall be paid to the personal representative of the Employee’s estate
within sixty (60) days after the date of the Employee’s death.

     10. Supersedes Other Agreements. This Agreement supersedes and is in lieu of any and all
other employment arrangements between the Employee and the Employer, including, but not limited to,
the Prior Agreement.

     11. Amendments. Any amendment to this Agreement shall be made in writing and signed by the
parties hereto.

     12. Enforceability. If any provision of this Agreement shall be invalid or unenforceable, in
whole or in part, then such provision shall be deemed to be modified or restricted to the extent
and in the manner necessary to render the same valid and enforceable, or shall be deemed excised
from this Agreement, as the case may require, and this Agreement shall be construed and enforced to
the maximum extent permitted by law as if such provision had been originally incorporated herein as
so modified or restricted or as if such provision had not been originally incorporated herein, as
the case may be.

     13. Governing Law. This Agreement shall be governed in all respects by the laws of the
Commonwealth of Pennsylvania without regard to the conflicts of laws principles of any

11

 

jurisdiction. Any legal proceeding arising out of or relating to this Agreement shall be
instituted in the United States District Court for the Eastern District of Pennsylvania, or if such
court does not have jurisdiction or will not accept jurisdiction, in the Court of Common Pleas in
and for the County in which the Employer’s principal place of business is located, and the Employee
hereby consents to the personal and exclusive jurisdiction of such court and hereby waives any
objection that the Employee may have to the laying of venue of any such proceeding and any claim or
defense of inconvenient forum.

     14. Assignment.

          (a) By the Employer. The rights and obligations of the Employer under this Agreement shall
inure to the benefit of, and shall be binding upon, the successors and assigns of the Employer.
This Agreement may be assigned by the Employer without the consent of the Employee. The Employer
shall require any successor (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business and/or assets of the Employer to expressly
assume and agree to perform this Agreement in the same manner and to the same extent that the
Employer would be required to perform it if no such succession had taken place. Unless expressly
provided otherwise, “Employer” as used herein shall mean the Employer as defined in this
Agreement and any successor to its business and/or assets as aforesaid.

          (b) By the Employee. This Agreement and the obligations created hereunder may not be assigned
by the Employee, but all rights of the Employee hereunder shall inure to the benefit of and be
enforceable by her heirs, devisees, legatees, executors, administrators and personal
representatives.

     15. Notices. All notices required or permitted to be given hereunder shall be in writing and
shall be deemed to have been given when mailed by certified mail, return receipt requested, or
delivered by a national overnight delivery service addressed to the intended recipient as follows:

If to the Employer:

NuPathe Inc.

227 Washington Street, Suite 200

Conshohocken, PA 19428

Attention: Chairman of the Board

If to the Employee:

Jane H. Hollingsworth

1249 Hazelwood Drive

Fort Washington, PA 19034

Any party may from time to time change its address for the purpose of notices to that party by a
similar notice specifying a new address, but no such change shall be deemed to have been given
until it is actually received by the party sought to be charged with its contents.

12

 

     16. Waivers. No claim or right arising out of a breach or default under this Agreement shall
be discharged in whole or in part by a waiver of that claim or right unless the waiver is supported
by consideration and is in writing and executed by the aggrieved party hereto or her or its duly
authorized agent. A waiver by any party hereto of a breach or default by the other party hereto of
any provision of this Agreement shall not be deemed a waiver of future compliance therewith, and
such provisions shall remain in full force and effect.

     17. Survival of Covenants. The provisions of Sections 5, 6, 7, and 8 hereof shall survive the
termination of this Agreement. Furthermore, any other provision of this Agreement that, by its
terms, is intended to continue beyond the termination of the Employee’s employment shall continue
in effect thereafter.

[space intentionally left blank; signature page follows]

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     IN WITNESS WHEREOF, this Agreement has been executed by the parties as of the date
first above written.

	 	 	 	 	 
	 	NUPATHE INC.

 	 
	 	By:  	/s/ Richard S. Kollender
 	 
	 	 	Title: Director 	 
	 	 	 	 
	 
	 	EMPLOYEE

 	 
	 	/s/  Jane H. Hollingsworth
 	 
	 	Jane H. Hollingsworth 	 
	 	 	 	 
	 

14exv10w16

Exhibit 10.16

EMPLOYMENT AGREEMENT

     THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into as of July 8, 2010,
by and between NuPathe Inc. (the “Employer”), a Delaware corporation, and Terri B. Sebree (the
“Employee”), but is effective as of the effective date of the registration statement relating to
the Employer’s initial public offering (the “Effective Date”).

Recitals

     WHEREAS, the Employer and the Employee previously entered into that certain Third Amended and
Restated Employment Agreement dated January 1, 2010 (the “Prior Agreement”); and

     WHEREAS, the Employer and the Employee desire to amend the Prior Agreement in various
respects; and

     WHEREAS, Section 12 of the Prior Agreement permits the Employer and the Employee to amend the
Prior Agreement pursuant to a written agreement executed by both parties; and

     WHEREAS, the Employer desires to continue to employ the Employee and the Employee desires to
continue to be employed by the Employer upon the terms and conditions hereinafter set forth.

     NOW, THEREFORE, in consideration of the premises and covenants set forth herein, and
intending to be legally bound hereby, the parties to this Agreement hereby agree as follows:

     1. Duties. The Employer agrees that the Employee shall continue to serve as President of the
Employer. The Employee shall report to the Board of Directors of the Employer (the “Board”). The
Employee agrees to be so employed by the Employer and to devote her best efforts and substantially
all of her business time to advance the interests of the Employer and to perform such executive,
managerial, administrative and financial functions as are required to develop the Employer’s
business and to perform other duties assigned to the Employee by the Board or the Chief Executive
Officer that are consistent with the Employee’s position. Nothing set forth herein shall prohibit
the Employee from engaging in personal investing activities. The Employee shall be permitted to
serve on the boards of directors of other entities whose businesses are not competitive with the
Employer in accordance with Employer policy.

     2. Term. This Agreement is effective as of the Effective Date, and, from and after the
Effective Date, will govern the Employee’s employment by the Employer until that employment ceases
in accordance with the terms of this Agreement.

     3. Compensation.

          (a) Salary. The Employee shall be paid a base salary at the annual rate of $305,000 (the
“Base Salary”) in accordance with the Employer’s regular payroll practices. The Board or the
Compensation Committee of the Board (the “Compensation Committee”) shall review the Base Salary for
appropriate increases at least annually at the end of each calendar year pursuant to the normal
performance review policies for senior level executives.

1

 

          (b) Incentive Compensation. The Employee shall participate in short-term and long-term
incentive programs, including equity compensation programs, established by the Employer for its
senior level executives generally, at levels determined by the Board or the Compensation Committee.
The Employee’s incentive compensation shall be subject to the terms of the applicable plans and
shall be determined based on the Employee’s individual performance and Employer performance as
determined by the Board or the Compensation Committee. Any annual incentive compensation earned by
the Employee shall be paid on or after January 1, but not later than March 15 of the fiscal year
following the fiscal year for which the annual incentive compensation is earned.

          (c) Retirement and Welfare Benefits. The Employee shall participate in employee retirement
and welfare benefit plans made available to the Employer’s senior level executives as a group or to
its employees generally, as such retirement and welfare plans may be in effect from time to time
and subject to the eligibility requirements of the plans. Nothing in this Agreement shall prevent
the Employer from amending or terminating any retirement, welfare or other employee benefit plans
or programs from time to time as the Employer deems appropriate.

          (d) Reimbursement of Expenses; Vacation. The Employee shall be reimbursed for all normal
items of travel, entertainment and miscellaneous business expenses reasonably incurred by the
Employee on behalf of the Employer, provided that such expenses are documented and submitted in
accordance with the reimbursement policies of the Employer as in effect from time to time. The
Employee shall be entitled to vacation and sick leave in accordance with the Employer’s vacation,
holidays and other pay for time not worked policies

     4. Termination.

          (a) Death. This Agreement shall automatically terminate effective as of the date of the
Employee’s death, in which event the Employer shall have no further obligation or liability under
this Agreement except that the Employer shall pay to the Employee’s estate: (i) any portion of the
Employee’s Base Salary for the period up to the Employee’s date of death that has been earned but
remains unpaid; and (ii) any benefits that have been earned, accrued and are due to the Employee
under the terms of the employee benefit plans of the Employer, which benefits shall be paid in
accordance with the terms of those plans; and (iii) the amount of the Earned Bonus as defined
herein. The Earned Bonus shall be paid at the same time bonuses are paid to employees of the
Employer generally in accordance with the terms of the Employer’s annual bonus plan.

          (b) Total Disability. In the event of the Employee’s Total Disability (as defined below), the
Employer may terminate the employment of the Employee, to the extent permitted by law, immediately
upon written notice to the Employee, in which event, the Employer shall have no further obligation
or liability under this Agreement except that the Employer shall pay to the Employee: (i) any
portion of the Employee’s Base Salary for the period up to the date of termination that has been
earned but remains unpaid; (ii) any benefits that have been earned, accrued and are due to the
Employee under the terms of the employee benefit plans of the Employer, which benefits shall be
paid in accordance with the terms of those plans; and (iii) the amount of the Earned Bonus as
defined herein. The Earned Bonus shall be

2

 

paid at the same time bonuses are paid to employees of the Employer generally in accordance
with the terms of the Employer’s annual bonus plan.

          (c) Termination by the Employer for Cause. Subject to any applicable right to cure under
Section 4(f)(i), the Employer may terminate the Employee’s employment at any time, effective
immediately, for Cause upon written notice to the Employee. In the event that the Employer
terminates the Employee pursuant to this Section 4(c), the Employer shall have no further
obligation or liability under this Agreement, except that the Employer shall pay to the Employee:
(i) any portion of the Employee’s Base Salary for the period up to the Termination Date that has
been earned but remains unpaid; and (ii) any benefits that have been earned, accrued and are due to
the Employee under the terms of the employee benefit plans of the Employer, which benefits shall be
paid in accordance with the terms of those plans.

          (d) Termination by the Employer Without Cause; Termination by the Employee for Good Reason.
The Employer may terminate the employment of the Employee for any reason other than those specified
in Section 4(b) or 4(c), including, without limitation, on or after a Change of Control, upon
thirty (30) days written notice (or Base Salary and benefit continuation in lieu of such thirty
(30) day notice) to the Employee. In addition, the Employee may terminate her employment at any
time, including, without limitation, on or after a Change of Control, upon written notice to the
Employer for Good Reason in accordance with the requirements of Section 4(e)(v).

In the event the Employer terminates the employment of the Employee for any reason other than those
specified in Section 4(b) or 4(c) hereof or the Employee terminates her employment for Good Reason,
the Employer shall pay to the Employee:

          (i) any portion of the Employee’s Base Salary for the period up to the Termination Date that
has been earned but remains unpaid;

          (ii) any benefits that have been earned, accrued and are due to the Employee under the terms
of any employee benefit plans of the Employer, which benefits shall be paid in accordance with the
terms of those plans; and

          (iii) subject to the execution and nonrevocation by the Employee of a release satisfactory to
the Employer and on reasonable, market level terms (the “Release”) and the Employee’s compliance
with all terms and provisions of this Agreement that survive the termination of the Employee’s
employment by the Employer, the Employer shall provide the Employee with the payments and benefits
set forth below. Notwithstanding any provision of this Agreement to the contrary, in no event
shall the timing of the Employee’s execution of the Release, directly or indirectly result in the
Employee designating the calendar year of payment and to the extent payment could be made in more
than one taxable year, payment shall be made in the later taxable year.

               (A) Severance in an amount equal to 1.0 times the Employee’s Base Salary at the rate in effect
at the time of the Employee’s termination. The severance amount shall be paid in equal monthly
installments in accordance with the Employer’s regular payroll

3

 

practices over a period of twelve (12) months, beginning within sixty (60) days following the
Termination Date;

               (B) the amount of the Earned Bonus which shall be paid at the same time bonuses are paid to
employees of the Employer generally in accordance with the terms of the Employer’s annual bonus
plan;

               (C) continued medical and dental coverage at the same level in effect at the Termination Date
(or generally comparable coverage) for a period of twelve (12) months following the Termination
Date for herself and, where applicable, her spouse and dependents, at the same premium rates as may
be charged from time to time for employees generally, as if the Employee had continued in
employment during such twelve (12) month period. The COBRA health care continuation period shall
run concurrently with the foregoing twelve (12) month period; and

               (D) vesting of all outstanding unvested stock options and other equity-based awards held by
the Employee as of the Termination Date that would have vested had the Employee remained employed
until the end of the calendar quarter in which the Termination Date occurs; provided, further, that
any outstanding unvested stock option or other equity-based award that vests based upon attainment
of performance criteria (each, a “Performance Award”) shall vest upon termination of the Employee’s
employment in accordance with the terms of the award agreement evidencing such Performance Award.

          (e) Effect of a Change of Control. Notwithstanding any provision of Section 4(d) to the
contrary, if the Employee’s employment is terminated pursuant to Section 4(d) within the ninety
(90) day period preceding a Change of Control or on or within twelve (12) months following a Change
of Control, the Employee shall be entitled to the same payments and benefits described in Section
4(d) above, subject to execution and nonrevocation of the Release and the Employee’s compliance
with all terms and provisions of this Agreement that survive the termination of the Employee’s
employment by the Employer; provided that (i) the severance multiplier in Section 4(d)(iv)(A) above
shall be 1.0 times the Employee’s Base Salary at the rate in effect at the time of the Employee’s
termination plus 1.0 times the Employee’s targeted annual bonus for the year in which the
Termination Date occurs, without regard to whether the relevant Employee and Employer goals have
been achieved, (ii) the period of continued medical and dental coverage in Section 4(d)(iv)(B)
above shall be twelve (12) months following the Termination Date and (iii) one hundred percent
(100%) of all outstanding unvested stock options and other equity-based awards held by the Employee
as of the Termination Date shall become fully vested and exercisable (to the extent applicable) as
of the Termination Date; provided, further, that any Performance Award shall vest upon termination
of the Employee’s employment in accordance with the terms of the award agreement evidencing such
Performance Award.

          Notwithstanding anything set forth in this Agreement to the contrary, if any payment or
benefit, including severance benefits, that the Employee would receive from the Employer in
connection with a Change of Control or otherwise (“Payment”) would (i) constitute a “parachute
payment” within the meaning of section 280G of the Code and (ii) but for this sentence, be subject
to the excise tax imposed by section 4999 of the Code (the “Excise Tax”), then such Payment shall
be reduced to the Reduced Amount. The “Reduced Amount” shall be

4

 

either (A) the largest portion of the Payment that would result in no portion of the Payment being
subject to the Excise Tax or (B) the largest portion, up to and including the total, of the
Payment, whichever amount, after taking into account all applicable federal, state and local
employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal
rate), results in the Employee’s receipt, on an after-tax basis, of the greater amount of the
Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax.
If a reduction in payments or benefits (or a cancellation of the acceleration of vesting of stock
options or equity awards) constituting “parachute payments” is necessary so that the Payment equals
the Reduced Amount, such reduction and/or cancellation of acceleration shall occur in the order
that provides the maximum economic benefit to the Employee. In the event that acceleration of
vesting of a stock option or equity award is to be reduced, such acceleration of vesting also shall
be canceled in the order that provides the maximum economic benefit to the Employee.

          The Employer shall appoint a nationally recognized accounting firm with appropriate subject
matter expertise to make the determinations required under this Section 4(e).

          The Employer shall bear all expenses with respect to the making of the determinations by such
accounting firm required to be made under this Section 4(e). The accounting firm engaged to make
the determinations under this Section 4(e) shall provide its calculations, together with detailed
supporting documentation, to the Employer and the Employee as soon as practicable after the date on
which the Employee’s right to a Payment is triggered (if requested at that time by the Employer or
the Employee) or such other time as requested by the Employer or the Employee. If the accounting
firm determines that no Excise Tax is payable with respect to a Payment, either before or after the
application of the Reduced Amount, it shall furnish the Employer with an opinion reasonably
acceptable to the Employee that no Excise Tax will be imposed with respect to such Payment. Any
good faith determinations of the accounting firm made under this Section 4(e) shall be final,
binding, and conclusive upon the Employer and the Employee.

          (f) Definitions.

	 	(i)	 	“Cause” shall be deemed to exist with respect
to any termination of employment by the Employer for any of the
following reasons:

	 	(1)	 	the Employee’s engagement in
conduct constituting breach of fiduciary duty, gross negligence
or willful misconduct relating to the Employer or the
performance of the Employee’s duties; provided that no act or
failure to act shall be deemed “willful” unless done, or omitted
to be done, by the Employee not in good faith or without
reasonable belief that the Employee’s action or omission was in
the best interest of the Employer;
	 
	 	(2)	 	the Employee’s substantial and
continued failure to perform the Employee’s material duties in a
satisfactory manner after written notice specifying the areas in
which

5

 

	 	 	 	performance is unsatisfactory and, if subject to cure, the
Employee’s failure to perform within thirty (30) days after
such notice;
	 
	 	(3)	 	the Employee’s commission of any
act of fraud with respect to the Employer;
	 
	 	(4)	 	the Employee’s violation of any
covenants or agreements in favor of the Employer regarding
confidentiality, non-competition and/or non-solicitation; or
	 
	 	(5)	 	the Employee’s conviction of a
felony or a crime involving moral turpitude under the laws of
the United States or any state or political subdivision thereof.

	 	 	 	Any notice required to be provided to the Employee under clause (2)
of this definition of “Cause” shall state that failure to
cure within the applicable period will result in termination for
Cause.

	 	(ii)	 	“Change of Control” shall have the same
meaning ascribed to such term under the Employer’s 2010 Omnibus Equity
Compensation Plan, as in effect on the date hereof and as it may be
amended from time to time.
	 
	 	(iii)	 	“Code” shall mean the Internal Revenue Code of
1986, as amended, and the regulations promulgated thereunder.
	 
	 	(iv)	 	“Earned Bonus” means the actual annual bonus
earned by the Employee for the fiscal year in which the Employee’s
Termination Date occurs; pro rated to reflect the portion of the fiscal
year during which the Employee was employed by the Employer, determined
by multiplying the full year bonus that would otherwise have been
payable to the Employee based upon the achievement of applicable
performance objectives by a fraction, the numerator of which is the
number of days during which the Employee was employed by the Employer
in the year of termination and the denominator of which is three
hundred sixty-five (365).
	 
	 	(v)	 	“Good Reason” shall be deemed to exist with
respect to any termination of employment by the Employee for any of the
following reasons:

	 	(1)	 	prior to or on or after a Change
of Control, a material reduction in the Employee’s duties and
responsibilities, which for purposes of this Agreement means the
assignment to Employee of any duties or responsibilities which
are materially inconsistent with or adverse to the

6

 

	 	 	 	Employee’s then current duties, responsibilities, positions
and/or titles with the Employer;
	 
	 	(2)	 	a material reduction of the
Employee’s then-current base salary or target bonus opportunity;
	 
	 	(3)	 	the requirement that the Employee
regularly report to work at a location that is more than fifty
(50) miles from the location of the Employee’s employment as of
the Effective Date;
	 
	 	(4)	 	a material breach of this
Agreement by the Employer; or
	 
	 	(5)	 	in the event of the assignment of
this Agreement to a third party, the failure of the assignee or
successor entity to agree to be bound to the terms of this
Agreement;

	 	 	 	provided, however, that for any of the foregoing to
constitute Good Reason, the Employee must provide written
notification of her intention to resign within ninety (90) days after
the Employee first knows or first has reason to know of the
occurrence of any such event or condition, and, the Employer must
have thirty (30) business days from the date of receipt of such
notice to effect a cure of the event or condition constituting Good
Reason. If the Employer fails to effect a cure of the event or
condition constituting Good Reason, the Employee must actually resign
from employment within thirty (30) days following the expiration of
the foregoing cure period. In the event of a cure of such event or
condition constituting Good Reason by the Employer, such event or
condition shall no longer constitute Good Reason.
	 
	 	(vi)	 	“Termination Date” shall mean the date on which
the Employee’s employment with the Employer terminates in accordance
with the applicable provisions of this Agreement.
	 
	 	(vii)	 	“Total Disability,” shall mean an illness,
incapacity or a mental or physical condition that renders the Employee
unable, despite the provision, if requested, of a reasonable
accommodation as that term is defined in the Americans with
Disabilities Act, to perform the essential functions of her employment
position for a continuous period of six (6) months or more.

          (g) No Mitigation. The Employee shall not be required to mitigate the amount of any payment
provided for in this Section 4 by seeking other employment or otherwise, nor shall the amount of
any payment or benefit provided for in this Section 4 be reduced by any compensation earned by the
Employee as the result of employment by another employer or self-employment, by retirement
benefits, by offset against any amounts (other than loans or advances

7

 

to the Employee by the Employer) claimed to be owed by the Employee to the Employer, or
otherwise.

     5. Non-Disclosure; Non-Competition and Prior Agreements.

          (a) Non-Disclosure. The Employee acknowledges that in the course of performing services for
the Employer, the Employee will obtain knowledge of the Employer’s business plans, products,
processes, software, know-how, trade secrets, formulas, methods, models, prototypes, discoveries,
inventions, improvements, disclosures, names and positions of employees and/or other proprietary
and/or confidential information (collectively the “Confidential Information”). The Employee agrees
to keep the Confidential Information secret and confidential and not to publish, disclose or
divulge to any other party, and the Employee agrees not to use any of the Confidential Information
for the Employee’s own benefit or to the detriment of the Employer without the prior written
consent of the Employer, whether or not such Confidential Information was discovered or developed
by the Employee. The Employee also agrees not to divulge, publish or use any proprietary and/or
confidential information of others that the Employer is obligated to maintain in confidence.

          (b) Non-Competition. The Employee agrees that, during her employment by the Employer
hereunder and for an additional period of twelve (12) months after the termination of the
Employee’s employment hereunder for any reason, neither the Employee nor any corporation or other
entity in which the Employee may be interested as a partner, trustee, director, officer, employee,
agent, shareholder, lender of money or guarantor, or for which he performs services in any capacity
(including as a consultant or independent contractor) shall at any time during such period be
engaged, directly or indirectly, in any Competitive Business (as that term is hereinafter defined).
The Employee shall not solicit or, if the Employee owns or has the right to acquire more than five
percent (5%) of the fully-diluted equity of the employing entity or its affiliates, hire, directly
or indirectly, any person that was employed by Employer during the six (6) month period immediately
preceding the Employee’s termination of employment with the Employer. For purposes of this Section
5(b) the term “Competitive Business” shall mean any job, role, or specific responsibilities within
a firm, company, or business organization that competes directly with the Employer’s business as in
effect at the time of the Employee’s termination of employment with the Employer or in a business
area planned in writing by the Employer before the Termination Date for entry within twelve (12)
months of the Termination Date at the time of the Employee’s termination of employment with the
Employer. The foregoing prohibition shall not prevent any employment or engagement of the
Employee, after termination of employment with the Employer, by any firm, company, or business
organization engaged in a Competitive Business as long as the activities of any such employment or
engagement, in any capacity, do not involve work on matters related to any business, product or
service being developed, manufactured, marketed, distributed or planned in writing by the Employer
at the time of the Employee’s termination of employment with the Employer. The Employee’s
ownership of no more than one percent (1%) of the outstanding voting stock of a publicly traded
company shall not constitute a violation of this Section 5(b). The Employee is entering into this
covenant not to compete in consideration of the agreements of the Employer in this Agreement,
including but not limited to, the agreement of the Employer to pay severance to the Employee upon a
termination of employment pursuant to Section 4(d) hereof and the agreement of the Employer to
accelerate the vesting of the Employee’s stock

8

 

options and other equity-based awards upon a Change of Control in accordance with the terms of
Section 4(d).

          (c) Prior Agreements. The Employee represents and warrants to the Employer that there are no
restrictions, agreements or understandings whatsoever to which the Employee is a party that would
prevent or make unlawful the Employee’s execution of this Agreement or the Employee’s employment
hereunder, is or would be inconsistent or in conflict with this Agreement or the Employee’s
employment hereunder, or would prevent, limit or impair in any way the performance by the Employee
of the obligations hereunder.

     6. Inventions and Discoveries.

          (a) Disclosure. The Employee shall promptly and fully disclose to the Employer, with all
necessary detail, all developments, know-how, discoveries, inventions, improvements, concepts,
ideas, formulae, processes and methods (whether copyrightable, patentable or otherwise) made,
received, conceived, acquired or written by the Employee (whether or not at the request or upon the
suggestion of the Employer, solely or jointly with others), during the period of her employment
with the Employer that (i) result from, arise out of, or relate to any work, assignment or task
performed by the Employee on behalf of the Employer, whether undertaken voluntarily or assigned to
the Employee within the scope of her responsibilities to the Employer, or (ii) were developed
using the Employer’s facilities or other resources or in Employer time, or (iii) result from the
Employee’s use or knowledge of the Employer’s Confidential Information, or (iv) relate to the
Employer’s business or any of the products or services being developed, manufactured or sold by the
Employer or that may be used in relation therewith (collectively referred to as “Inventions”). The
Employee hereby acknowledges that all original works of authorship that are made by the Employee
(solely or jointly with others) within the above terms and that are protectable by copyright are
“works made for hire,” as that term is defined in the United States Copyright Act. The Employee
understands and hereby agrees that the decision whether or not to commercialize or market any
Invention developed by the Employee solely or jointly with others is within the Employer’s sole
discretion and for the Employer’s sole benefit and that no royalty shall be due to the Employee as
a result of the Employer’s efforts to commercialize or market any such Invention.

          (b) Assignment and Transfer. The Employee agrees to assign and transfer to the Employer all
of the Employee’s right, title and interest in and to the Inventions, and the Employee further
agrees to deliver to the Employer any and all drawings, notes, specifications and data relating to
the Inventions, and to sign, acknowledge and deliver all such further papers, including
applications for and assignments of copyrights and patents, and all renewals thereof, as may be
necessary to obtain copyrights and patents for any Inventions in any and all countries and to vest
title thereto in the Employer and its successors and assigns and to otherwise protect the
Employer’s interests therein. The Employee shall not charge the Employer for time spent in
complying with these obligations. If the Employer is unable because of the Employee’s mental or
physical incapacity or for any other reason to secure the Employee’s signature to apply for or to
pursue any application for any United States or foreign patents or copyright registrations covering
Inventions or original works of authorship assigned to the Employer as above, then the Employee
hereby irrevocably designates and appoints the Employer and its duly authorized officers and agents
as the Employee’s agent and attorney in fact, to act for and in the Employee’s

9

 

behalf and stead to execute and file any such applications and to do all other lawfully
permitted acts to further the prosecution and issuance of letters patent or copyright registrations
thereon with the same legal force and effect as if executed by the Employee.

          (c) Records. The Employee agrees that in connection with any research, development or other
services performed for the Employer, the Employee will maintain careful, adequate and
contemporaneous written records of all Inventions, which records shall be the property of the
Employer.

     7. Employer Documentation. The Employee shall hold in a fiduciary capacity for the benefit of
the Employer all documentation, disks, programs, data, records, drawings, manuals, reports,
sketches, blueprints, letters, notes, notebooks and all other writings, electronic data, graphics
and tangible information and materials of a secret, confidential or proprietary information nature
relating to the Employer or the Employer’s business that are in the possession or under the control
of the Employee.

     8. Injunctive Relief. The Employee acknowledges that her compliance with the agreements in
Sections 5, 6, and 7 hereof is necessary to protect the good will and other proprietary interests
of the Employer and that she is one of the principal executives of the Employer and conversant with
its affairs, its trade secrets and other proprietary information. The Employee acknowledges that a
breach of any of her agreements in Sections 5, 6 and 7 hereof will result in irreparable and
continuing damage to the Employer for which there will be no adequate remedy at law; and the
Employee agrees that in the event of any breach of the aforesaid agreements, the Employer and its
successors and assigns shall be entitled to injunctive relief and to such other and further relief
as may be proper.

     9. Application of Section 409A of the Internal Revenue Code.

          (a) Compliance. This Agreement shall be interpreted to avoid any penalty sanctions under
section 409A of the Code. If any payment or benefit cannot be provided or made at the time
specified herein without incurring sanctions under section 409A of the Code, then such benefit or
payment shall be provided in full at the earliest time thereafter when such sanctions will not be
imposed. For purposes of section 409A of the Code, all payments to be made upon a termination of
employment under this Agreement may only be made upon a “separation from service” under section
409A of the Code, each payment made under this Agreement shall be treated as a separate payment,
and the right to a series of installment payments under this Agreement is to be treated as a right
to a series of separate payments. In no event shall the Employee, directly or indirectly,
designate the calendar year of payment. All reimbursements provided under this Agreement shall be
made or provided in accordance with the requirements of section 409A of the Code, including, where
applicable, the requirement that (i) any reimbursement is for expenses incurred during the
Employee’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the
amount of expenses eligible for reimbursement during a calendar year may not affect the expenses
eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible
expense will be made on or before the last day of the calendar year following the year in which the
expense is incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange
for another benefit.

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          (b) Payment Delay. Notwithstanding any provision in this Agreement to the contrary, if at
the time of the Employee’s termination of employment with the Employer, the Employer has securities
which are publicly-traded on an established securities market and the Employee is a “specified
employee” (as defined in section 409A of the Code) and it is necessary to postpone the commencement
of any severance payments otherwise payable pursuant to this Agreement as a result of such
termination of employment in order to prevent any accelerated or additional tax under section 409A
of the Code, then the Employer shall postpone the commencement of the payment of any such payments
or benefits hereunder (without any reduction in such payments or benefits ultimately paid or
provided to the Employee) that are not otherwise paid within the short-term deferral exception
under section 409A of the Code and are in excess of the lesser of two (2) times (i) the Employee’s
then-annual compensation or (ii) the limit on compensation then set forth in section 401(a)(17) of
the Code, until the first payroll date that occurs after the date that is six (6) months following
the Employee’s “separation from service” with the Employer (as defined under section 409A of the
Code). If any payments are postponed due to such requirements, such postponed amounts shall be
paid in a lump sum to the Employee, and any installment payments due to the Employee shall
recommence, on the first payroll date that occurs after the date that is six (6) months following
the Employee’s “separation from service” with the Employer. If the Employee dies during the
postponement period prior to the payment of the postponed amount, the amounts withheld on account
of section 409A of the Code shall be paid to the personal representative of the Employee’s estate
within sixty (60) days after the date of the Employee’s death.

     10. Supersedes Other Agreements. This Agreement supersedes and is in lieu of any and all
other employment arrangements between the Employee and the Employer, including, but not limited to,
the Prior Agreement.

     11. Amendments. Any amendment to this Agreement shall be made in writing and signed by the
parties hereto.

     12. Enforceability. If any provision of this Agreement shall be invalid or unenforceable, in
whole or in part, then such provision shall be deemed to be modified or restricted to the extent
and in the manner necessary to render the same valid and enforceable, or shall be deemed excised
from this Agreement, as the case may require, and this Agreement shall be construed and enforced to
the maximum extent permitted by law as if such provision had been originally incorporated herein as
so modified or restricted or as if such provision had not been originally incorporated herein, as
the case may be.

     13. Governing Law. This Agreement shall be governed in all respects by the laws of the
Commonwealth of Pennsylvania without regard to the conflicts of laws principles of any
jurisdiction. Any legal proceeding arising out of or relating to this Agreement shall be
instituted in the United States District Court for the Eastern District of Pennsylvania, or if such
court does not have jurisdiction or will not accept jurisdiction, in the Court of Common Pleas in
and for the County in which the Employer’s principal place of business is located, and the Employee
hereby consents to the personal and exclusive jurisdiction of such court and hereby waives any
objection that the Employee may have to the laying of venue of any such proceeding and any claim or
defense of inconvenient forum.

11

 

     14. Assignment.

          (a) By the Employer. The rights and obligations of the Employer under this Agreement shall
inure to the benefit of, and shall be binding upon, the successors and assigns of the Employer.
This Agreement may be assigned by the Employer without the consent of the Employee. The Employer
shall require any successor (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business and/or assets of the Employer to expressly
assume and agree to perform this Agreement in the same manner and to the same extent that the
Employer would be required to perform it if no such succession had taken place. Unless expressly
provided otherwise, “Employer” as used herein shall mean the Employer as defined in this
Agreement and any successor to its business and/or assets as aforesaid.

          (b) By the Employee. This Agreement and the obligations created hereunder may not be assigned
by the Employee, but all rights of the Employee hereunder shall inure to the benefit of and be
enforceable by her heirs, devisees, legatees, executors, administrators and personal
representatives.

     15. Notices. All notices required or permitted to be given hereunder shall be in writing and
shall be deemed to have been given when mailed by certified mail, return receipt requested, or
delivered by a national overnight delivery service addressed to the intended recipient as follows:

If to the Employer:

NuPathe Inc.

227 Washington Street, Suite 200

Conshohocken, PA 19428

Attention: Chairman of the Board

If to the Employee:

Terri B. Sebree

922 Merion Square Road

Gladwyne, PA 19035

Any party may from time to time change its address for the purpose of notices to that party by a
similar notice specifying a new address, but no such change shall be deemed to have been given
until it is actually received by the party sought to be charged with its contents.

     16. Waivers. No claim or right arising out of a breach or default under this Agreement shall
be discharged in whole or in part by a waiver of that claim or right unless the waiver is supported
by consideration and is in writing and executed by the aggrieved party hereto or her or its duly
authorized agent. A waiver by any party hereto of a breach or default by the other party hereto of
any provision of this Agreement shall not be deemed a waiver of future compliance therewith, and
such provisions shall remain in full force and effect.

     17. Survival of Covenants. The provisions of Sections 5, 6, 7 and 8 hereof shall survive the
termination of this Agreement. Furthermore, any other provision of this Agreement

12

 

that, by its terms, is intended to continue beyond the termination of the Employee’s
employment shall continue in effect thereafter.

[space intentionally left blank; signature page follows]

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     IN WITNESS WHEREOF, this Agreement has been executed by the parties as of the date
first above written.

	 	 	 	 	 
	 	NUPATHE INC.

 	 
	 	By:  	/s/  Jane H. Hollingsworth
 	 
	 	 	Title: Chief Executive Officer 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	EMPLOYEE

 	 
	 	/s/  Terri B. Sebree
 	 
	 	Terri B. Sebree 	 
	 	 	 
	 

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