Document:

<PAGE>

                                                                    Exhibit 10.4

                                  AMENDMENT TO
                    AMENDED AND RESTATED BUILT-TO-SUIT LEASE

            THIS AMENDMENT TO AMENDED AND RESTATED BUILT-TO-SUIT LEASE (the
"AMENDMENT") is made effective as of January 11, 2005 by and between BMR-201
Industrial Road LLC, a Delaware limited liability company (formerly known as
Inhale 201 Industrial Road, L.P., the "LANDLORD") and Nektar Therapeutics, a
Delaware corporation (formerly known as Inhale Therapeutic Systems, Inc., the
"TENANT").

                                    RECITALS

            A.    Landlord and Tenant have entered in that certain Amended and
Restated Built-To-Suit Lease dated August 17, 2004 (the "LEASE"), of that
certain real property located at 201 Industrial Road, San Carlos, California,
including: (i) the second floor, the third floor and the fourth floor of
Building 1 (collectively, "PHASE 1"), and (ii) 45,574 rentable square feet
located on the third floor of Building 2 ("PHASE 2A" and, together with the
Phase 1, the "LEASED PREMISES"). Capitalized terms used herein and not otherwise
defined herein shall have the meaning assigned thereto in the Lease.

            B.    Tenant no longer wishes to occupy Phase 2A. Landlord is
willing to enter into a Lease with Nuvelo, Inc., a Delaware corporation
("NUVELO") (the "NUVELO LEASE") to lease Phase 2A to Nuvelo.

            C.    Landlord and Tenant now wish to amend this Lease to, among
other things, terminate Tenant's lease of Phase 2A to allow Landlord to enter
into a new lease with Nuvelo, all as and to the extent more particularly set
forth below.

                                    AGREEMENT

            NOW THEREFORE, in consideration of the foregoing and other good and
valuable consideration, Landlord and Tenant hereby agree as follows:

            1.    RECITAL D. The following defined terms are added to Recital D
of the Lease:

                  "NUVELO: shall mean Nuvelo, Inc., a Delaware corporation."

                  "NUVELO RENT COMMENCEMENT DATE: shall mean the date the Nuvelo
      is required to commence paying rent under the Nuvelo Lease or October 1,
      2005, whichever is sooner."

                  "NUVELO EFFECTIVE DATE: shall mean the date that the Nuvelo
      Lease is executed and is in full force and effect, which the parties agree
      shall be January 2005."

                  "NUVELO LEASE: shall mean that certain Lease dated as of
      January 2005 between Nuvelo and Landlord, pursuant to which Nuvelo is
      leasing Phase 2A."

<PAGE>

            2.    AMENDMENT TO SECTION 1.1(a). Section 1.1(a), excluding Section
1.1(a)(i)-1.1(a)(x) of the Lease is hereby amended and restated in its entirety
as follows:

                  "(a)  Subject to the Parking Lease dated as of September 14,
      2000 (the "PARKING LEASE") by and between Landlord and Tenant, Landlord
      leases to Tenant and Tenant leases from Landlord, on the terms, covenants
      and conditions hereinafter set forth, Phase 1A, Phase 1B, and Phase 2A
      (all as defined below and referred to collectively herein as the
      "PREMISES"). As of the effective date of this Amendment, all of Tenant's
      rights and obligations to Phase 2A shall expire and the Premises shall
      consist of Phase 1A and Phase 1B only. The Premises, together with Phase
      2B, were constructed by Landlord; and are located in two connected
      four-story buildings containing an aggregate of approximately 390,000
      square feet, consisting of approximately 171,965 square feet of rentable
      area for office and laboratory research and development and two lower
      stories primarily of parking (collectively, the "BUILDINGS" and each a
      "BUILDING"). The Buildings were constructed on the Real Property in
      connection with the Project."

            3.    AMENDMENT TO SECTION 3.1(c)(II). Section 3.1(c)(ii) of the
Lease is hereby amended and restated in its entirety as follows:

                  "(ii) Phase 2A. Beginning on the Phase 2A Rent Commencement
      Date and terminating on January 31, 2005, Tenant shall pay Minimum Rental
      for Phase 2A in an amount equal to $164,066.40 ($3.60 per sq. ft.
      multiplied by 45,574)."

            4.    AMENDMENT TO SECTION 4. Section 4 of the Lease is hereby
amended and restated in its entirety as follows:

                  "PARKING. Landlord and Tenant agree that the Common Areas of
      the Real Property shall include not less than 690 parking spaces.
      Commencing on the Effective Date and ending on the Building 1 Termination
      Date, Tenant shall be entitled to 224 spaces, all in addition to those
      spaces provided in and subject to the Parking Lease."

            5.    AMENDMENT TO SECTION 5.1(b). Section 5.1(b) of the Lease is
hereby amended and restated in its entirety as follows:

                  "(b)  Tenant Work; Phase 2A; Improvements. (i) Tenant has
      constructed Tenant Improvements within Phase 1A and Phase 1B of the
      Premises in accordance with the prior lease, and may make such future
      improvements and modifications to the same as set forth herein. Tenant and
      Landlord agreed under the Original Lease to provide Tenant with a Tenant
      Improvement Allowance for tenant improvements within each Phase of the
      Premises equal to $100 per Usable Square Foot. Landlord and Tenant agree
      that Landlord shall have satisfied its obligation to provide a Tenant
      Improvement Allowance for Phase 2A once Landlord has satisfied its
      obligations under the following Section 5.1(b)(ii).

                  (ii)  Landlord shall provide a tenant improvement allowance to
      Nuvelo in the amount of not less than $100 per Usable Square Foot for
      improvements to Phase 2A, in accordance with the Nuvelo Lease. Tenant
      shall reimburse Landlord for a portion of such allowance ("Tenant's TI
      Reimbursement"), calculated as follows: (i) the difference

<PAGE>

      between (a) the amount actually funded by Landlord as a tenant improvement
      allowance to Nuvelo under the Nuvelo Lease (including any amounts provided
      to Nuvelo as rent credits), but in no event more than $6,380,360 [45,574
      sf x $140/sf] and (b) $4,397,200 [43,972 sf x $100/sf]; (ii) times 28.57%.
      Tenant's TI Reimbursement shall be paid in two installments, the first
      installment of $283,294.40 shall be paid upon execution of this Amendment
      and the balance shall be paid on December 31, 2005."

            6.    AMENDMENT TO SECTION 7.1 (a) (IV). Section 7.1(a)(iv) of the
Lease is hereby amended and restated in its entirety as follows:

                  "(iv) The term `TENANT'S OPERATING COST SHARE' means 72.98%
through and until the Nuvelo Rent Commencement Date and thereafter means 46.47%.
`Tenant's Exterior COMMON AREA COST SHARE' shall be equal to the Tenant's
Operating Cost Share as established from time to time."

            7.    AMENDMENT TO SECTION 13.1(e). Section 13.1(e) of the Lease is
hereby deleted in its entirety and replaced with "[Intentionally Deleted]."

            8.    CONDITION PRECEDENT. This Amendment shall be conditioned upon
execution and delivery of the Nuvelo Lease by Nuvelo and Landlord.

            9.    LEASE TERMINATION. For and in consideration of Landlord's
agreement to terminate Tenant's interest in Phase 2A as provided herein, Tenant
agrees to pay Landlord the following sums:

            (a)   TERMINATION FEE. Tenant shall pay Landlord the sum of $50,000
upon execution of this Amendment.

            (b)   CONTINUING PAYMENTS. Tenant shall pay Landlord the sum of
$3,216,816.40 in accordance with the schedule attached hereto as Exhibit "A."

            (c)   REIMBURSEMENT OF BROKERS' FEES. Tenant agrees to reimburse
Landlord for a portion of the brokerage fees and commissions payable by Landlord
in connection with the Nuvelo Lease, as follows: Tenant shall pay Landlord the
sum of $102,536.37 upon execution of this Amendment and the sum of $102,536.37
on August 13, 2005. Subject to Tenant's reimbursement obligations herein,
Landlord agrees that it shall be responsible for, and shall indemnify Tenant
from and against, any and all brokerage fees and commissions payable in
connection with the Nuvelo Lease.

            10.   CONDITION UPON SURRENDER. Upon the Nuvelo Effective Date,
Tenant shall surrender Phase 2A, including any additions, alterations and
improvements thereto, broom clean, in the same condition received, free from
Hazardous Materials caused to be present by Tenant, its agents or invitees,
ordinary wear and tear excepted, and delivered free of radioactive licenses or
other restrictions on use, first, however, removing all goods and effects of
Tenant.

            11.   HAZARDOUS MATERIALS. As of the date of this Amendment, Tenant
represents and warrants that Phase 2A is free from Hazardous Materials caused to
be present by Tenant and that Tenant's use of Phase 2A has not been and Phase 2A
is not in violation of any

<PAGE>

laws with respect to the disposal or storage of Hazardous Substances, human
health or the environment as the result of any actions of Tenant.

            12.   NO FURTHER AMENDMENT. Except as expressly amended or modified
by this Amendment, each and every term and provision of the Lease remains in
full force and effect, without modification or amendment. This Amendment shall
be construed together with and as a part of the Lease.

            13.   COUNTERPARTS. This Amendment may be executed in several
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same Amendment. Except as amended hereby,
the Lease shall remain in full force and effect.

            IN WITNESS WHEREOF, the undersigned have executed this Amendment as
of the day and year first above written.

                                        LANDLORD

                                        BMR-201 INDUSTRIAL ROAD LLC,
                                        a Delaware limited liability company

                                        By: /s/ GARY A. KREITZER
                                            -----------------------------------
                                                Name:  Gary A. Kreitzer
                                                Title: Executive Vice President

                                        TENANT

                                        NEKTAR THERAPEUTICS,
                                        a Delaware corporation

                                        By: /s/ AJAY BANSAL
                                            -----------------------------------
                                                Name:  Ajay Bansal
                                                Title: Chief Financial Officer

                                        By: /s/ AJIT GILL
                                                -------------------------------
                                                Name:  Ajit Gill
                                                Title: President and Chief
                                                       Executive Officer

<PAGE>

                                   EXHIBIT "A"
                                PAYMENT SCHEDULE

<TABLE>
<CAPTION>
Payment Date                    Amount
------------                    ------
<S>                         <C>
  02/01/05                     174,108.58
  03/01/05                     174,108.58
  04/01/05                     174,108.58
  05/01/05                     174,108.58
  06/01/05                     174,108.58
  07/01/05                     174,108.58
  08/01/05                     118,243.67
  09/01/05                      82,960.58
  10/01/05                      85,881.11
  11/01/05                      86,442.75
  12/01/05                      86,442.75
  01/01/06                      86,442.75
  02/01/06                      86,442.75
  03/01/06                      86,442.75
  04/01/06                      86,442.75
  05/01/06                      86,442.75
  06/01/06                      86,442.75
  07/01/06                      86,442.75
  08/01/06                      86,442.75
  09/01/06                      86,442.75
  10/01/06                      89,421.69
  11/01/06                      89,994.56
  12/01/06                      89,994.56
  01/01/07                      89,994.56
  02/01/07                      89,994.56
  03/01/07                      89,994.56
  04/01/07                      89,994.56
  05/01/07                      89,994.56
  06/01/07                      89,994.56
  07/01/07                      89,994.56
  08/01/07                      34,836.60

    Total                   $3,216,816.40
</TABLE><PAGE>

                                                                    Exhibit 10.5

                            BIOMED REALTY TRUST, INC.

                        2004 EQUITY INCENTIVE AWARD PLAN

                        RESTRICTED STOCK AWARD AGREEMENT

      THIS RESTRICTED STOCK AWARD AGREEMENT (this "Agreement") is made as of
_____________, 2005, by and between BioMed Realty Trust, Inc., a Maryland
corporation (the "Company"), and __________ (the "Participant"). This Agreement
is subject to all of the terms and conditions as set forth herein and in the
Company's 2004 Equity Incentive Award Plan (the "Plan"), which is incorporated
herein by reference. Capitalized terms not defined herein shall have the
meanings assigned to such terms in the Plan.

      The parties agree as follows:

      1.    Sale of Stock.

            (a)   Subject to the terms and conditions of this Agreement and the
Plan, the Company hereby agrees to issue to the Participant __________ shares of
the Company's Stock (the "Shares") for good and valuable consideration which the
Company has determined to exceed the par value of the Company's Stock.

            (b)   The issuance of the Shares under this Agreement shall occur at
the principal office of the Company simultaneously with the execution of this
Agreement by the parties or on such other date as the Company and the
Participant shall agree (the "Issuance Date"). Subject to the provisions of
Section 4 below, on the Issuance Date, the Company will deliver to the
Participant a certificate representing the Shares to be issued to the
Participant (which shall be issued in the Participant's name).

      2.    Forfeiture Restriction.

            (a)   Subject to the provisions of Section 2(b) below, if the
Participant ceases to be an Employee, Director or Consultant of the Company, the
Partnership or any of their Subsidiaries for any or no reason, all of the
Unreleased Shares (as defined below) shall thereupon be forfeited immediately
and without any further action by the Company (the "Forfeiture Restriction").
Upon the occurrence of such a forfeiture, the Company shall become the legal and
beneficial owner of the Shares being forfeited and all rights and interests
therein or relating thereto, and the Company shall have the right to retain and
transfer to its own name the number of Shares being forfeited by the
Participant.

<PAGE>

            (b)   Provided that the Participant continues to be an Employee,
Director or Consultant of the Company, the Partnership or any of their
Subsidiaries on such date, the Shares shall be released from the Forfeiture
Restriction as follows:

            (c)   Any of the Shares which, from time to time, have not yet been
released from the Forfeiture Restriction are referred to herein as "Unreleased
Shares."

            3.    Restrictions on Transfer. No Unreleased Shares or any interest
or right therein or part thereof shall be liable for the debts, contracts or
engagements of the Participant or his successors in interest or shall be subject
to disposition by transfer, alienation, anticipation, pledge, encumbrance,
assignment or any other means whether such disposition be voluntary or
involuntary or by operation of law by judgment, levy, attachment, garnishment or
any other legal or equitable proceedings (including bankruptcy), and any
attempted disposition thereof shall be null and void and of no effect.

      4.    Escrow of Shares.

            (a)   The Participant hereby authorizes and directs the secretary of
the Company, or such other person designated by the Board, to transfer the
Unreleased Shares which have been forfeited by the Participant to the Company.

            (b)   To insure the availability for delivery of the Participant's
Unreleased Shares in the event of forfeiture of such Shares by the Participant
pursuant to Section 2, the Participant hereby appoints the secretary, or any
other person designated by the Administrator as escrow agent, as its
attorney-in-fact to assign and transfer unto the Company, such Unreleased
Shares, if any, forfeited by the Participant pursuant to Section 2 and shall,
upon execution of this Agreement, deliver and deposit with the secretary of the
Company, or such other person designated by the Administrator, the share
certificates representing the Unreleased Shares, together with the stock
assignment duly endorsed in blank, attached hereto as Exhibit A. The Unreleased
Shares and stock assignment shall be held by the secretary in escrow, pursuant
to the Joint Escrow Instructions of the Company and the Participant attached as
Exhibit B hereto, until the shares are forfeited by the Participant as provided
in Section 2, until such Unreleased Shares are released from the Forfeiture
Restriction, or until such time as this Agreement no longer is in effect. Upon
release of the Unreleased Shares, the escrow agent shall deliver to the
Participant the certificate or certificates representing such Shares in the
escrow agent's possession belonging to the Participant in accordance with the
terms of the Joint Escrow Instructions attached as Exhibit B hereto, and the
escrow agent shall be discharged of all further obligations hereunder; provided,
however, that the escrow agent shall nevertheless retain such certificate or
certificates as escrow agent if so required pursuant to other restrictions
imposed pursuant to this Agreement.

            (c)   The Company, or its designee, shall not be liable for any act
it may do or omit to do with respect to holding the Shares in escrow and while
acting in good faith and in the exercise of its judgment.

                                       2
<PAGE>

      5.    Stock Certificate Legends. The share certificate(s) evidencing the
Shares issued hereunder shall be endorsed with the following legends and any
other legend required by any applicable state securities laws:

            THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO FORFEITURE
            IN FAVOR OF THE COMPANY AND MAY BE TRANSFERRED ONLY IN ACCORDANCE
            WITH THE TERMS OF A RESTRICTED STOCK AWARD AGREEMENT BETWEEN THE
            COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE
            SECRETARY OF THE COMPANY.

      6.    Adjustment for Stock Split. All references to the number of Shares
in this Agreement shall be appropriately adjusted to reflect any stock split,
reverse stock split or stock dividend or other similar change in the Shares
which may be made by the Company after the date of this Agreement.

      7.    Taxes. Notwithstanding anything to the contrary in this Agreement,
the Company shall be entitled to require payment to the Company, the Partnership
or any of their Subsidiaries in cash or deduction from other compensation
payable to the Participant of any sums required by federal, state or local tax
law to be withheld with respect to the issuance or lapsing of restrictions on
the Shares. The Company shall not be obligated to deliver any new certificate
representing vested Shares to the Participant or his legal representative unless
and until the Participant or his legal representative shall have paid or
otherwise satisfied in full the amount of all federal, state and local taxes
applicable to the taxable income of the Participant resulting from the grant of
the Shares or the lapse or removal of the Forfeiture Restriction.

      8.    Section 83(b). Participant covenants that he or she will not make an
election under Section 83(b) of the Code with respect to the receipt of any of
the Shares without the consent of the Administrator, which the Administrator may
grant or withhold in its sole discretion.

      9.    Ownership Limit and REIT Status. The Forfeiture Restriction on the
Shares shall not lapse if the lapsing of such restrictions would likely result
in any of the following:

            (a)   a violation of the restrictions or limitations on ownership
provided for from time to time under the terms of the organizational documents
of the Company; or

            (b)   income to the Company that could impair the Company's status
as a real estate investment trust, within the meaning of Section 856 through 860
of the Code.

      10.   Rights as Stockholder. Except as otherwise provided herein, upon
delivery of the Shares to the escrow holder pursuant to Section 4, Participant
shall have all the rights of a stockholder with respect to said Shares, subject
to the restrictions herein, including the right to vote the Shares and to
receive all dividends or other distributions paid or made with respect to the
Shares.

                                       3
<PAGE>

      11.   Limitations Applicable to Section 16 Persons. Notwithstanding any
other provision of the Plan or this Agreement, if the Participant is subject to
Section 16 of the Exchange Act, the Plan, the Shares and this Agreement shall be
subject to any additional limitations set forth in any applicable exemptive rule
under Section 16 of the Exchange Act (including any amendment to Rule 16b-3 of
the Exchange Act) that are requirements for the application of such exemptive
rule. To the extent permitted by applicable law, this Agreement shall be deemed
amended to the extent necessary to conform to such applicable exemptive rule.

      12.   General Provisions.

            (a)   This Agreement shall be governed by the laws of the State of
California, without regard to conflicts of law principles thereof. This
Agreement may only be modified or amended in a writing signed by both parties.

            (b)   The Plan is incorporated herein by reference. This Agreement
and the Plan constitute the entire agreement between the Company and the
Participant concerning the subject matter hereof. Any previous agreement between
the Company and the Participant concerning the subject matter hereof is hereby
terminated and superseded by this Agreement. Subject to the foregoing, the
provisions hereof shall inure to the benefit of, and be binding upon, the
successors, permitted assigns, heirs, executors and administrators of the
parties hereto. Any attempted transfer of this Agreement not in compliance with
the terms hereof shall be null and void.

            (c)   Either party's failure to enforce any provision or provisions
of this Agreement shall not in any way be construed as a waiver of any such
provision or provisions, nor prevent that party thereafter from enforcing each
and every other provision of this Agreement. The rights granted both parties
herein are cumulative and shall not constitute a waiver of either party's right
to assert all other legal remedies available to it under the circumstances.

            (d)   THE PARTICIPANT ACKNOWLEDGES AND AGREES THAT THE LAPSING OF
THE FORFEITURE RESTRICTION PURSUANT TO SECTION 2 HEREOF IS EARNED ONLY BY
CONTINUING SERVICE TO THE COMPANY, THE PARTNERSHIP OR ONE OF THEIR SUBSIDIARIES
AS AN "AT WILL" EMPLOYEE OR CONSULTANT OF THE COMPANY, THE PARTNERSHIP OR ONE OF
THEIR SUBSIDIARIES OR A DIRECTOR OF THE COMPANY (AND NOT THROUGH THE ACT OF
BEING HIRED OR ACQUIRING SHARES HEREUNDER). THE PARTICIPANT FURTHER ACKNOWLEDGES
AND AGREES THAT THIS AGREEMENT, THE TRANSACTIONS CONTEMPLATED HEREUNDER AND THE
FORFEITURE RESTRICTION SCHEDULE SET FORTH HEREIN DO NOT CONSTITUTE AN EXPRESS OR
IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS AN EMPLOYEE, CONSULTANT OR DIRECTOR
FOR SUCH PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL NOT INTERFERE WITH THE
COMPANY'S RIGHT TO TERMINATE THE PARTICIPANT'S EMPLOYMENT OR SERVICE TO THE
COMPANY AT ANY TIME, WITH OR WITHOUT CAUSE.

            (e)   Any notice or other communication required or permitted
hereunder shall be in writing and shall be delivered personally or sent by
facsimile transmission, overnight air courier, or first class certified or
registered mail, postage prepaid, and addressed to the parties at

                                       4
<PAGE>

the addresses of the parties set forth at the end of this Agreement or such
other address as a party may designate by five (5) days' advance written notice
to the other parties hereto. All notices and communications shall be deemed to
have been received unless otherwise set forth herein: (i) in the case of
personal delivery, on the date of such delivery; (ii) in the case of facsimile
transmission, on the date on which the sender receives electronic confirmation
that such notice was received by the addressee; (iii) in the case of overnight
air courier, on the second business day following the day sent, with receipt
confirmed by the courier; and (iv) in the case of mailing by first class
certified or registered mail, postage prepaid, return receipt requested, on the
fifth business day following such mailing.

            (f)   If any term or provision of this Agreement or the application
thereof to any person, property or circumstance shall to any extent be invalid
or unenforceable, the remainder of this Agreement, or the application of such
term or provision to persons, property or circumstances other than those as to
which it is invalid or unenforceable, shall not be affected thereby, and each
term and provision of this Agreement shall be valid and enforceable to the
fullest extent permitted by law.

            (g)   The provisions of this Agreement shall apply, to the full
extent set forth herein with respect to the Shares, to any and all shares of
capital stock or other securities which may be issued in respect of, or in
exchange for, in substitution of the Shares, and shall be appropriately adjusted
for any stock dividends, splits, reverse splits, combinations, recapitalizations
and the like occurring after the date hereof.

            (h)   This Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

            (i)   The headings of the sections of this Agreement are for
convenience and shall not by themselves determine the interpretation of this
Agreement. The language used in this Agreement will be deemed to be the language
chosen by the parties to express their mutual intent and no rule of strict
construction will be applied against any party.

            (j)   By his or her signature below, the Participant agrees to be
bound by the terms and conditions of the Plan. The Participant has reviewed the
Plan in its entirety, has had an opportunity to obtain the advice of counsel
prior to executing this Agreement and fully understands all provisions of the
this Agreement and the Plan. The Participant hereby agrees to accept as binding,
conclusive and final all decisions or interpretations of the Administrator of
the Plan upon any questions arising under the Plan or this Agreement.

                                       5
<PAGE>

      IN WITNESS WHEREOF, the parties have duly executed this Agreement as of
the day and year first set forth above.

BIOMED REALTY TRUST, INC.:                  PARTICIPANT:

By: _________________________________       ____________________________________
    Name:
    Title:

Address:                                    Address:

BioMed Realty Trust, Inc.
17140 Bernardo Center Drive
Suite 222
San Diego, California 92128

                                CONSENT OF SPOUSE

      I, ____________________, spouse of ____________________, have read and
approve the foregoing Agreement. In consideration of issuing to my spouse the
shares of the common stock of BioMed Realty Trust, Inc. set forth in the
Agreement, I hereby appoint my spouse as my attorney-in-fact in respect to the
exercise of any rights under the Agreement and agree to be bound by the
provisions of the Agreement insofar as I may have any rights in said Agreement
or any shares of the common stock of BioMed Realty Trust, Inc. issued pursuant
thereto under the community property laws or similar laws relating to marital
property in effect in the state of our residence as of the date of the signing
of the foregoing Agreement.

Dated: _______________, 2005

                                                   _____________________________
                                                   Signature of Spouse

                                       6
<PAGE>

                                    EXHIBIT A

                                STOCK ASSIGNMENT

      FOR VALUE RECEIVED, the undersigned, _______________, hereby sells,
assigns and transfers unto BIOMED REALTY TRUST, INC., a Maryland corporation,
_______ shares of the Common Stock of BIOMED REALTY TRUST, INC., a Maryland
corporation, standing in its name of the books of said corporation represented
by Certificate No. _____ herewith and do hereby irrevocably constitute and
appoint ___________________ to transfer the said stock on the books of the
within named corporation with full power of substitution in the premises.

      This Stock Assignment may be used only in accordance with the Restricted
Stock Award Agreement between BIOMED REALTY TRUST, INC. and the undersigned
dated ___________, 2005.

Dated: _______________, 200__
                                                   ________________________

INSTRUCTIONS: Please do not fill in the blanks other than the signature line.
The purpose of this assignment is to enable the Company to enforce the
Forfeiture Restriction as set forth in the Restricted Stock Award Agreement,
without requiring additional signatures on the part of the stockholder.

<PAGE>

                                    EXHIBIT B

                            JOINT ESCROW INSTRUCTIONS

                                                            ______________, 2005

Secretary
BioMed Realty Trust, Inc.
17140 Bernardo Center Drive
Suite 222
San Diego, California 92128

Ladies and Gentlemen:

      As escrow agent (the "Escrow Agent") for both BioMed Realty Trust, Inc., a
Maryland corporation (the "Company"), and the undersigned recipient of stock of
the Company (the "Participant"), you are hereby authorized and directed to hold
in escrow the documents delivered to you pursuant to the terms of that certain
Restricted Stock Award Agreement ("Agreement") between the Company and the
undersigned (the "Escrow"), in accordance with the following instructions:

      1.    In the event of forfeiture by the Participant of any of the shares
owned by the Participant pursuant to the Forfeiture Restriction set forth in the
Agreement, the Company and/or any assignee of the Company (referred to
collectively for convenience herein as the "Company") shall give to the
Participant and you a written notice specifying the number of shares of stock
forfeited and the date of forfeiture. The Participant and the Company hereby
irrevocably authorize and direct you to effect the forfeiture contemplated by
such notice in accordance with the terms of said notice.

      2.    As of the date of forfeiture indicated in such notice, you are
directed (a) to date the stock assignments necessary for the forfeiture and
transfer in question, (b) to fill in the number of shares being forfeited and
transferred, and (c) to deliver the same, together with the certificate
evidencing the shares of stock to be forfeited and transferred, to the Company
or its assignee.

      3.    The Participant irrevocably authorizes the Company to deposit with
you any certificates evidencing shares of stock to be held by you hereunder and
any additions and substitutions to said shares as defined in the Agreement. The
Participant does hereby irrevocably constitute and appoint you as the
Participant's attorney-in-fact and agent for the term of this escrow to execute
with respect to such securities all documents necessary or appropriate to make
such securities negotiable and to complete any transaction herein contemplated,
including but not limited to the filing with any applicable state blue sky
authority of any required applications for consent to, or notice of transfer of,
the securities. Subject to the provisions of this paragraph 3, the Participant
shall exercise all rights and privileges of a stockholder of the Company while
the stock is held by you.

<PAGE>

      4.    Upon written request of the Participant, but no more than once per
calendar month, unless the Forfeiture Restriction has been enforced, you will
deliver to the Participant a certificate or certificates representing so many
shares of stock as are not then subject to the Forfeiture Restriction. Within
one hundred twenty (120) days after any voluntary or involuntary termination of
the Participant's services to the Company for any or no reason, you will deliver
to the Participant a certificate or certificates representing the aggregate
number of shares held or issued pursuant to the Agreement and not forfeited
pursuant to the Forfeiture Restriction set forth in Section 2 of the Agreement.

      5.    If at the time of termination of this escrow you should have in your
possession any documents, securities, or other property belonging to the
Participant, you shall deliver all of the same to the Participant and shall be
discharged of all further obligations hereunder.

      6.    Your duties hereunder may be altered, amended, modified or revoked
only by a writing signed by all of the parties hereto.

      7.    You shall be obligated only for the performance of such duties as
are specifically set forth herein and may rely and shall be protected in relying
or refraining from acting on any instrument reasonably believed by you to be
genuine and to have been signed or presented by the proper party or parties. You
shall not be personally liable for any act you may do or omit to do hereunder as
Escrow Agent or as attorney-in-fact for the Participant while acting in good
faith, and any act done or omitted by you pursuant to the advice of your own
attorneys shall be conclusive evidence of such good faith.

      8.    You are hereby expressly authorized to disregard any and all
warnings given by any of the parties hereto or by any other person or
corporation, excepting only orders or process of courts of law and are hereby
expressly authorized to comply with and obey orders, judgments or decrees of any
court. In case you obey or comply with any such order, judgment or decree, you
shall not be liable to any of the parties hereto or to any other person, firm or
corporation by reason of such compliance, notwithstanding any such order,
judgment or decree being subsequently reversed, modified, annulled, set aside,
vacated or found to have been entered without jurisdiction.

      9.    You shall not be liable in any respect on account of the identity,
authorities or rights of the parties executing or delivering or purporting to
execute or deliver the Agreement or any documents or papers deposited or called
for hereunder.

      10.   You shall not be liable for the expiration of any rights under any
applicable state, federal or local statute of limitations or similar statute or
regulation with respect to these Joint Escrow Instructions or any documents
deposited with you.

      11.   You shall be entitled to employ such legal counsel and other experts
as you may deem necessary properly to advise you in connection with your
obligations hereunder, may rely upon the advice of such counsel, and may pay
such counsel reasonable compensation therefor.

                                       2
<PAGE>

      12.   Your responsibilities as Escrow Agent hereunder shall terminate if
you shall cease to be an officer or agent of the Company or if you shall resign
by written notice to each party. In the event of any such termination, the
Company shall appoint a successor Escrow Agent.

      13.   If you reasonably require other or further instruments in connection
with these Joint Escrow Instructions or obligations in respect hereto, the
necessary parties hereto shall join in furnishing such instruments.

      14.   It is understood and agreed that should any dispute arise with
respect to the delivery and/or ownership or right of possession of the
securities held by you hereunder, you are authorized and directed to retain in
your possession without liability to anyone all or any part of said securities
until such disputes shall have been settled either by mutual written agreement
of the parties concerned or by a final order, decree or judgment of a court of
competent jurisdiction after the time for appeal has expired and no appeal has
been perfected, but you shall be under no duty whatsoever to institute or defend
any such proceedings.

      15.   Any notice or other communication required or permitted hereunder
shall be in writing and shall be delivered personally or sent by facsimile
transmission, overnight air courier, or first class certified or registered
mail, postage prepaid, and addressed to the parties at the addresses of the
parties set forth at the end of these Joint Escrow Instructions or such other
address as a party may designate by five (5) days' advance written notice to the
other parties hereto. All notices and communications shall be deemed to have
been received unless otherwise set forth herein: (i) in the case of personal
delivery, on the date of such delivery; (ii) in the case of facsimile
transmission, on the date on which the sender receives electronic confirmation
that such notice was received by the addressee; (iii) in the case of overnight
air courier, on the second business day following the day sent, with receipt
confirmed by the courier; and (iv) in the case of mailing by first class
certified or registered mail, postage prepaid, return receipt requested, on the
fifth business day following such mailing.

      16.   By signing these Joint Escrow Instructions, you become a party
hereto only for the purpose of said Joint Escrow Instructions; you do not become
a party to the Agreement.

      17.   This instrument shall be binding upon and inure to the benefit of
the parties hereto, and their respective successors and permitted assigns.

      18.   These Joint Escrow Instructions shall be governed by, and construed
and enforced in accordance with, the laws of the State of California, without
regard to conflicts of law principles thereof.

                            (Signature Page Follows)

                                       3
<PAGE>

      IN WITNESS WHEREOF, the parties have executed these Joint Escrow
Instructions as of the date first written above.

                                          Very truly yours,

                                          BIOMED REALTY TRUST, Inc.

                                          By: __________________________________
                                          Name:
                                          Title:

                                          Address: 17140 Bernardo Center Drive
                                                   Suite 222
                                                   San Diego, California 92128

                                          PARTICIPANT:

                                          ______________________________________

                                          Address:

ESCROW AGENT:

By: _____________________________
    Gary A. Kreitzer,
    Secretary, BioMed Realty Trust, Inc.

Address: 17140 Bernardo Center Drive
         Suite 222
         San Diego, California 92128

                                       4

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