Document:

Exhibit 10.8

 Exhibit 10.8 
 STANDARD LEASE 
 WITH 

StemCo Biomedical, Inc. 
  

			
	 SUITES:
	  	144 and 148
		
	 BUILDING:
	  	2810 Meridian
		
	 CITY:
	  	Durham, North Carolina

 TABLE OF CONTENTS 
  

					
			
	 ARTICLE 1:
	  	BASIC PROVISIONS	  	1
			
	 ARTICLE 2:
	  	TERM AND COMMENCEMENT	  	3
			
	 ARTICLE 3:
	  	BASE RENT AND ADDITIONAL RENT	  	3
			
	 ARTICLE 4:
	  	CONDITION OF PREMISES	  	6
			
	 ARTICLE 5:
	  	QUIET ENJOYMENT	  	7
			
	 ARTICLE 6:
	  	UTILITIES AND SERVICES	  	7
			
	 ARTICLE 7:
	  	USE, COMPLIANCE WITH LAWS, AND RULES	  	8
			
	 ARTICLE 8:
	  	MAINTENANCE AND REPAIRS	  	9
			
	 ARTICLE 9:
	  	ALTERATIONS AND LIENS	  	10
			
	 ARTICLE 10:
	  	INSURANCE, SUBROGATION, AND WAIVER OF CLAIMS	  	11
			
	 ARTICLE 11:
	  	CASUALTY DAMAGE	  	12
			
	 ARTICLE 12:
	  	CONDEMNATION	  	13
			
	 ARTICLE 13:
	  	ASSIGNMENT AND SUBLETTING	  	14
			
	 ARTICLE 14:
	  	PERSONAL PROPERTY, RENT AND OTHER TAXES	  	16
			
	 ARTICLE 15:
	  	LANDLORD’S REMEDIES	  	16
			
	 ARTICLE 16:
	  	SECURITY DEPOSIT	  	19
			
	 ARTICLE 17:
	  	ATTORNEYS’ FEES, JURY TRIAL AND VENUE	  	20
			
	 ARTICLE 18:
	  	SUBORDINATION, ATTORNMENT AND LENDER PROTECTION	  	20
			
	 ARTICLE 19:
	  	ESTOPPEL CERTIFICATES	  	21
			
	 ARTICLE 20:
	  	RIGHTS RESERVED BY LANDLORD	  	21
			
	 ARTICLE 21:
	  	LANDLORD’S RIGHT TO CURE	  	22
			
	 ARTICLE 22:
	  	INDEMNIFICATION	  	22
			
	 ARTICLE 23:
	  	RETURN OF POSSESSION	  	23
			
	 ARTICLE 24:
	  	HOLDING OVER	  	23
			
	 ARTICLE 25:
	  	NOTICES	  	24
			
	 ARTICLE 26:
	  	REAL ESTATE BROKERS	  	24
			
	 ARTICLE 27:
	  	NO WAIVER	  	24
			
	 ARTICLE 28:
	  	TELECOMMUNICATION LINES	  	25
			
	 ARTICLE 29:
	  	HAZARDOUS MATERIALS	  	25
			
	 ARTICLE 30:
	  	DEFINITIONS	  	28
			
	 ARTICLE 31:
	  	OFFER	  	31
			
	 ARTICLE 32:
	  	MISCELLANEOUS	  	31
			
	 ARTICLE 33:
	  	ENTIRE AGREEMENT	  	33
			
	 EXHIBITS
	  		  	Listed in Article 1.P

  

					
		  	i	  	

 STANDARD LEASE 
 THIS STANDARD LEASE (“Lease”) is made and entered into as of the ___ day of June, 2003, by and between CMD PROPERTIES, INC.
(“Landlord”), an Illinois corporation, and StemCo Biomedical, Inc. (‘Tenant”), a Delaware corporation. 
 ARTICLE 1: BASIC PROVISIONS 
 This Article contains the basic tease provisions between Landlord and Tenant.

  

					
	 A. Building:
	  	2810 Meridian, located at 2810 Meridian Parkway, Durham, North Carolina (the “Property”, as further described in Article 30).
		
	 B. Premises:
	  	Suites 144 and 148 located in the Building as outlined or hatched on Exhibit A hereto.
		
	 C. Commencement Date:
	  	May 1, 2004 for Suite 148 or such earlier date as the Andcare Lease may be terminated as further described in Article 2 below (sometimes referred to herein as the
“Suite 148 Commencement Date”) and September 1, 2005 for Suite 144 or such earlier date as the PRI Lease may be terminated as further described in Article 2 below (sometimes referred to herein as the “Suite 144 Commencement
Date”), subject to Articles 2 and 4. The term “Commencement Date” as used herein shall mean either the Suite 148 Commencement Date or the Suite 144 Commencement Date, or both, as the context reasonably implies.
		
	 D. Expiration Date:
	  	April 30, 2008, subject to Articles 2 and 4.
		
	 E. Rentable Area:
	  	The rentable area of the Premises shall be deemed to be 11,021 square feet, consisting of 3,954 for Suite 148 and 7,067 for Suite 144, and the rentable area of the
Property shall be deemed to be 100,878 square feet, for purposes of this Lease, subject to Article 30.
		
	 F. Tenant’s Share:
	  	Three and 92/100 percent (3.92%) until the Suite 144 Commencement Date and thereafter ten and 93/100 percent (10.93%), subject to Articles 3 and 30.
		
	 G. Base Rent:
	  	Tenant shall pay monthly Base Rent pursuant to the following schedule and as described in Article 3:

				
		
	 Period
	  	Monthly Base Rent
	Suite 148 Commencement Date – April 30, 2005	  	$	3,225.81
	May 1, 2005 – day immediately prior to Suite 144 Commencement Date	  	$	3,322.58
	 Suite 144 Commencement Date – April 30,2006
	  	$	9,256.31
	 May 1, 2006 – April 30, 2007
	  	$	9,534.00
	 May 1, 2007 – Expiration Date
	  	$	9,820.02

  

					
		  	1	  	

					
	 H. Additional Rent:
	  	Tenant shall pay Tenant’s Share of Taxes, Insurance and Expenses as further described in Article 3.
		
	 I. Permitted Use:
	  	General office and minor or “light” laboratory, subject to Article 7.
		
	 J. Security Deposit:
	  	$9,256.31, subject to Article 16.
		
	 K. Broker:
	  	Advantis GVA, subject to Article 26.
		
	 L. Guarantor(s):
	  	n/a
	
	 M. Landlord’s Notice Address (subject to Article 25):

		
		  	c/o CMD Realty Investors, L.P., Suite 450, 2100 RiverEdge Parkway, Atlanta, Georgia 30328, Attn.: Regional Manager; with copies c/o CMD Realty Investors, L.P., 227 West
Monroe Street, Suite 3900, Chicago, Illinois 60606, Attn.: General Counsel and Attn.: Asset Manager.
	
	 N. Tenant’s Notice Address (subject to Article 25):

		
		  	StemCo Biomedical, Inc. 2810 Meridian, Suite 148, Durham, North Carolina 27713
		
	 O. Rent Payments:
	  	Rent shall be paid to Landlord c/o Bank One, P.O. Box 93150, Chicago, Illinois 60673-3150, or such other parties and addresses as to which Landlord shall provide advance
notice.
		
	 P. Exhibits:
	  	This Lease includes, and incorporates by this reference:
			
		  	Exhibit A:	  	Premises
		  	Exhibit B:	  	Rules
		  	Exhibit C:	  	Extension Option
		  	Exhibit D:	  	Right of Offer
		  	Exhibit E:	  	Option to Terminate

 The above provisions shall be interpreted and applied in accordance with the other provisions of this
Lease. The terms of this Article, and the terms defined in Article 30 and other Articles, shall have the meanings specified therefor when used as capitalized terms in other provisions of this Lease or related documentation (except as expressly
provided to the contrary therein). 
  

					
		  	2	  	

 ARTICLE 2: TERM AND COMMENCEMENT 
 A. Term. Landlord hereby leases to Tenant and Tenant hereby leases from Landlord the Premises for the Term, subject to
the other provisions of this Lease. The term (“Term”) of this Lease shall commence on the applicable Commencement Date for each suite and end on the Expiration Date set forth in Article 1, unless sooner terminated as provided in this
Lease, subject to adjustment as provided below and the other provisions of this Lease. 
 B. Suite 148. The
parties acknowledge and agree that: (i) Tenant is currently occupying Suite 148 pursuant to a Sublease dated December 14, 2000, as amended (“Andcare Sublease”) from Andcare, Inc. (“Andcare”), that will
terminate on April 30, 2004 or such earlier date on which the lease between Andcare and Landlord (“Andcare Lease”) is terminated (as contemplated in the Consent to Sublease dated January 11, 2001 between Landlord, Tenant
and Andcare), (ii) the Suite 148 Commencement Date herein Rent and Tenant’s other obligations hereunder shall be advanced to such earlier date on which the Andcare Sublease and Andcare Lease are terminated, and (iii) in such event,
the Base Rent under Article 1.G of this Lease shall be as follows: $4,136.50 per month for the period commencing on the date of the Lease and ending on April 30, 2004. If the Commencement Date is advanced to an earlier date under Article 1.C
hereof due to an earlier termination of the Andcare Lease, the Expiration Date herein shall not be changed. 
 C.
Suite 144. The parties acknowledge and agree that: (i) Tenants currently occupying Suite 144 pursuant to a Subsublease dated February 2, 2003, as amended (“PRI Subsublease”) from MD Everywhere, Inc.
(“MD”), MD itself being a subtenant pursuant to a Sublease dated on or about January 8, 2001 (“PRI Sublease”) from PRI Associates, Inc. (“PRI”); and that the Sublease and Subsublease will
terminate on August 31, 2005 or such earlier date on which the lease between PRI and Landlord (“PRI Lease”) is terminated (as contemplated in the Consent to Sub-Sublease dated February 3, 2003 between Landlord, PRI, MD and
Tenant and the Consent to Sublease dated January 8, 2001 between Landlord, MD and PRI), (ii) the Suite 144 Commencement Date herein and Tenant’s other obligations hereunder shall be advanced to such earlier date on which the PRI
Sub-sublease, PRI Sublease and PRI Lease are terminated, and (iii) in such event, the Base Rent under Article 1.G of this Lease shall be as follows. $5,594.71 per month (escalated by 3% on February 3, 2004 and February 3, 2005) for
the period beginning on the date of this Lease and ending on August 31, 2005. If the Commencement Date is advanced to an earlier date under Article 1.C hereof due to an earlier termination of the PRI Lease, the Expiration Date herein shall not
be changed. 
 D. Adjustments and Confirmation. Tenant shall execute a confirmation of any Commencement
Date as adjusted herein in such form as Landlord may reasonably request; any failure to respond within thirty (30) days after requested shall be deemed an acceptance of the date set forth in Landlord’s confirmation. 
 ARTICLE 3: BASE RENT AND ADDITIONAL RENT 
 A. Base Rent. Tenant shall pay Landlord the monthly Base Rent set forth in Article 1 in advance on or before the first day of each calendar month during the Term; provided, Tenant shall pay Base
Rent for the first full calendar month for which Base Rent is due no later than three (3) months before the applicable Commencement Date. 
 B. Taxes, Insurance and Expenses. Subject to the limitations in Paragraph I below, Tenant shall pay Landlord Tenant’s Share of Taxes, Insurance and Expenses in the manner described below. The
foregoing capitalized terms shall have the meanings specified therefor in Articles 1 and 30. 
  

					
		  	3	  	

 C. Payments. 
 (i) Landlord may reasonably estimate in advance the amounts Tenant shall owe for Taxes, Insurance and Expenses for any full or partial
calendar year of the Term. Tenant shall pay such estimated amounts, on a monthly basis, on or before the first day of each calendar month, together with Tenant’s payment of Base Rent. Landlord may reasonably adjust such estimate from time to
time. 
 (ii) Within 120 days after the end of each calendar year, or as soon thereafter as practicable, Landlord shall provide
a statement (the “Statement”) showing: (a) the amount of actual Taxes, Insurance and Expenses for such calendar year, with a listing of amounts for major categories of Expenses, (b) any amount paid by Tenant towards Taxes,
insurance and Expenses during such calendar year on an estimated basis, and (c) any revised estimate of Tenant’s obligations for such items for the current year. 
 (iii) If the Statement shows that Tenant’s estimated payments were less than Tenant’s actual obligations for Taxes, Insurance and
Expenses for such year, Tenant shall pay the difference within thirty (30) days after Tenant receives the Statement. If the Statement shows that Tenant’s estimated payments exceeded Tenant’s actual obligations for Taxes, Insurance and
Expenses, Landlord shall credit the difference against the payment of Rent next due. However, if the Term shall nave expired and no further Rent shall be due, Landlord shall provide a prompt refund of such difference with the final Statement for
such year and this obligation will survive expiration or earlier termination of the Lease. 
 (iv) If the Statement shows a
further increase in Tenant’s estimated payments for the current calendar year, Tenant shall: (a) thereafter pay the new estimated amount until Landlord further revises such estimated amount, and (b) pay the difference between the new
and former estimates for the period from January 1 of the current calendar year through the month in which the Statement is sent within thirty (30) days after Tenant receives the Statement. 
 (v) In lieu of providing one Statement covering Taxes, Insurance and Expenses, Landlord may provide separate statements. So long as
Tenant’s obligations hereunder are not materially adversely affected thereby, Landlord reserves the right to reasonably change the manner or timing of Tenant’s payments for Taxes, Insurance and Expenses. 
 D. Tax Refunds, Protest Costs, Fiscal Years and Special Assessments. Landlord shall each year: (i) credit against Taxes any
refunds received during such year, whether or not for a prior year, (ii) include in Taxes any additional amount paid during such year involving an adjustment to Taxes for a prior year due to supplemental assessment or other reason,
(iii) for Taxes payable in installments over more than one year, include only the minimum amounts payable each year and any interest thereon, and (iv) include, in either Taxes or Expenses, any reasonable fees for attorneys, consultants and
experts, and other costs paid during such year in attempting to protest, appeal or otherwise seek to reduce or minimize Taxes. Notwithstanding anything to the contrary contained in this Lease, if any taxing authority, at any time, uses a fiscal year
other than a current calendar year, Landlord may require payments by Tenant based on: (a) amounts paid or payable during each calendar year, or (b) amounts paid or payable for or during each fiscal tax year. 
 E. Grossing Up and Tenant’s Share Adjustments. In order to allocate variable Expenses (i.e. those items that vary based on
occupancy levels) among those parties who are leasing space when the Property is not fully occupied during all or a portion of any calendar year, Landlord may reasonably determine the amount of such variable Expenses that would have been paid had
the Property been fully occupied, and the amount so determined shall be deemed to have been the amount of variable Expenses for such year (rather than adjusting Tenant’s Share by subtracting vacant space from the denominator). Similarly, if
Landlord is not furnishing any particular utility or service to a tenant during any period (the cost of which, if performed by Landlord, would be included in Expenses), such as where a single building tenant in a complex arranges for its own
landscaping, Landlord may for such period: (i) exclude the rentable area of such tenant from the rentable area of the Property in computing Tenant’s Share of such utility or service, or (ii) adjust Expenses to reflect the additional
amount that would reasonably have been incurred had Landlord furnished such utility or service to such tenant (rather than adjusting Tenant’s Share). “Tenant’s Share” shall be subject to other adjustments under the definition
thereof in Article 30. 
  

					
		  	4	  	

 The preceding Paragraph is not intended to allow Landlord to make a profit on such Expenses,
nor to permit Landlord to collect from Tenant and other tenants more than 100% of such Expenses actually incurred by Landlord, but rather is intended to provide that Tenant and other tenants receiving such utilities or services pay their respective
shares of the Expenses for variable utilities or services that are actually incurred. The general concept of “grossing up” contained in the preceding Paragraph is illustrated by the following general hypothetical: (a) a building
contains 100,000 feet, (b) occupancy is 50% or 50,000 feet, (c) actual janitorial cost for 100% occupancy would be $10,000, (d) actual janitorial cost for 50% occupancy is $5,000, (e) with no “gross up,” tenants pay the
landlord $2,500 (50% of $5,000), (f) with the gross up, tenants would pay the actual $5,000 of janitorial costs (50% of $10,000), thus permitting the landlord to recover variable costs actually incurred, (g) the landlord would
absorb fixed costs for vacant space with no adjustment. The foregoing illustration is intended to help demonstrate that “grossing up” is designed to ensure that Tenant pays its fair share of variable costs actually incurred as a
result of its occupancy. 
 F. Prorations; Payments After Term Ends. If the Term commences on a day other than the first
day of a calendar month or ends on a day other than the last day of a calendar month, the Base Rent and any other amounts payable on a monthly basis shall be prorated on a per diem basis for such partial calendar months. If the Base Rent is
scheduled to increase under Article 1 other than on the first day of a calendar month, the amount for such month shall be prorated on a per diem basis to reflect the number of days of such month at the then current and increased rates, respectively.
If the Term commences other than on January 1, or ends other than on December 31, Tenant’s obligations to pay amounts towards Taxes, Insurance and Expenses for such first or final calendar years shall be prorated on a per diem basis
to reflect the portion of such years included in the Term. Tenant’s obligations to pay any amounts accruing during, or relating to, the period prior to expiration or earlier termination of this Lease, shall survive such expiration or
termination. 
 G. Landlord’s Accounting Practices and Records. Landlord shall maintain records respecting Taxes,
Insurance and Expenses and determine the same in accordance with sound accounting and management practices consistently applied in accordance with this Lease. Tenant’s employees (or any certified public accounting firm acting for Tenant on a
non-contingent fee basis) shall have the right to review such records by sending notice to Landlord no later than thirty (30) days following the furnishing of the Statement specifying such records as Tenant reasonably desires to review. Such
review shall be subject to the continuing condition that Tenant not be in Default, and subject to reasonable scheduling by Landlord during normal business hours at the place or places where such records are normally kept. No later than thirty
(30) days after Landlord makes such records available for review, Tenant shall send Landlord notice specifying any exceptions that Tenant takes to matters included in such Statement, Tenant’s detailed reasons for each exception which
support a conclusion that such exception properly identifies an error in such Statement, and a complete copy of the review report. Such Statement shall be considered final and binding on Tenant, except as to matters to which exception is taken after
review of Landlord’s records in the foregoing manner and within the foregoing times. The foregoing times for sending Tenant’s notices hereunder are critical to Landlord’s budgeting process, and are therefore of the essence of this
Paragraph. If Tenant takes timely exception as provided herein, Landlord may seek certification from an independent certified public accountant or financial consultant (who shall be subject to Tenant’s reasonable approval) as to the proper
amount of Taxes, Insurance and Expenses or the items as to which Tenant has taken exception. In such case: (i) such certification shall be considered final and binding on both parties (except as to additional amounts not then known or omitted
by error), and (ii) Tenant shall pay Landlord for the cost of such certification, unless it shows that Taxes, Insurance and Expenses were overstated by a net amount of five percent (5%) or more. Pending review of such records and
resolution of any exceptions, Tenant shall pay the amounts shown on such Statement, subject to credit, refund or additional payment after any such exceptions are resolved. 
 H. General Payment Matters. Base Rent, Taxes, Insurance, Expenses and any other amounts which Tenant is or becomes obligated
to pay Landlord under this Lease or other agreement entered in connection herewith are sometimes herein referred to collectively as “Rent,” and all remedies applicable to the non-payment of rent shall be applicable thereto. Tenant shall
pay Rent in good funds and legal tender of the United States of America, together with any applicable sales tax or other taxes on

  

					
		  	5	  	

 
Rent as further described in Article 14. Tenant shall pay Rent without any deduction, recoupment, set-off or counterclaim, and without relief from any valuation or appraisement laws, except as
may be expressly provided in this Lease. No delay by Landlord in providing the Statement (or separate statements) shall be deemed a default by Landlord or a waiver of Landlord’s right to require payment of Tenant’s obligations for actual
or estimated Taxes, Insurance or Expenses. In no event shall a decrease in Taxes, Insurance or Expenses serve to decrease Base Rent. Landlord may apply payments received from Tenant to any obligations of Tenant then accrued, without regard to
obligations designated by Tenant. 
 I. Cap On Controllable Expenses. Notwithstanding anything to the contrary contained
in this Lease, Landlord hereby agrees that, for purposes of computing Tenant’s obligations for Expenses, increases in Controllable Expenses (as defined below) during the initial Term shall not exceed six percent (6%) of Controllable
Expenses (the “Controllable Expense Cap”), on an average, cumulative basis, subject to the following provisions: (i) “Controllable Expenses” for purposes hereof shall mean all Expenses, except that Landlord may exclude
therefrom Utility Costs, Taxes and other costs imposed or established by governmental or regulatory authorities and Insurance, (ii) “average, cumulative basis” for purposes hereof shall mean that, if Controllable Expenses either
decrease, or increase by less than the foregoing Controllable Expense Cap amount, in any year or years, then Landlord may apply the difference between Controllable Expenses and the Controllable Expense Cap for such year or years so as to increase
the Controllable Expense Cap in another year or years, so long as Controllable Expenses do not exceed the foregoing Controllable Expense Cap on an average, cumulative basis during the initial Term, and (iii) this provision is personal to the
Tenant first named in this Lease, and shall no longer apply if Tenant assigns this Lease by operation of law or otherwise or subleases all or a material portion of the Premises. For example, if Controllable Expenses increase by 5% in 2003 and 5% in
2004, they could increase by 8% in 2005 because they would not increase by more than 6% per year on an average, cumulative basis, if Controllable Expenses then increase by a further 8% in 2006, they would be limited to the 6% cap amount for
purposes of computing Tenant’s obligations for 2006 in order to keep within the 6% average, cumulative increase. If Controllable Expenses then increase by only 4% in 2007, Landlord may include the extra 2% that Landlord was prevented from using
in 2006, so long as Tenant’s obligations for Controllable Expenses do not increase by more than 6% per year on an average, cumulative basis. 
 ARTICLE 4: CONDITION OF PREMISES 
 A. Condition of Premises. Tenant
is currently entitled to enter and occupy the Premises pursuant to the Andcare Sublease and Consent to Sublease and PRI Sublease and Consent to Sublease referred to in Article 2 above, and has inspected, or had an opportunity to inspect, the
Premises (and portions of the Property, Systems and Equipment providing access to or serving the Premises), and agrees to accept the same “as is” without any agreements, representations, understandings or obligations on the part of
Landlord to perform any alterations, repairs or improvements except as set forth in the following sentence. Landlord shall, within sixty (60) days after execution and delivery of this Lease by both parties, perform all work necessary to bring
the section of drainage piping identified in the email dated April 22, 2003 from Pete Padron of Project Planning and Delivery to Kelly Bolick into compliance with applicable codes. 
 B. Subsequent Tenant Work. Notwithstanding the foregoing to the contrary, Landlord shall provide an allowance
(“Allowance”) of up to $100,000.00 to be used towards reasonable, direct out-of-pocket costs of designing and performing permanent leasehold improvements in the Premises during the period beginning on the date that this Lease has
been executed and delivered by both parties and ending on December 31, 2003 (the “Subsequent Tenant Work”). Tenant shall engage its own designers and contractors, and Landlord shall reimburse Tenant based on Tenant’s
submission of a customary tenant’s affidavit respecting the work, invoices, paid receipts and other reasonable evidence of payment, and the submission of customary architect’s certificates, lien waivers and affidavits of payment, all
reasonably satisfactory to Landlord. Any unused portion of the Allowance shall belong to Landlord. Such Subsequent Tenant Work shall be subject to applicable provisions of the Lease, including Landlord’s

  

					
		  	6	  	

 
approval of the contractors and plans for the work under Article 9 of the Lease, and all such work shall also be subject to the approval of Andcare with respect to Suite 148 and PRI and MD with
respect to Suite 144 as further provided in the applicable Sublease and Subsublease. Any personal property, trade fixtures or equipment, including, but not limited to, modular or other furniture, and cabling or other items for communications or
computer systems, whether or not shown on any plan approved by Landlord, shall be provided by Tenant, at Tenant’s sole cost. Landlord shall be entitled manage the Subsequent Tenant Work and to receive an administrative fee equal to three
percent (3%) of all other amounts included in the cost of the Subsequent Tenant Work. There shall be no postponement of any Commencement Date or abatement of Rent as a result of any Subsequent Tenant Work or delays in substantially completing
the same, under any circumstances. 
 ARTICLE 5: QUIET ENJOYMENT 
 Landlord agrees that, if Tenant timely pays the Rent and performs the terms and provisions hereunder, Tenant shall hold the Premises during
the Term free of lawful claims by any party acting by or through Landlord, subject to all other terms and provisions of this Lease. 
 ARTICLE 6: UTILITIES AND SERVICES 
 A. Tenant To Obtain Utilities and Services. Tenant shall obtain in
Tenant’s own name and pay the utility company or other provider directly for all utilities and services furnished to or for the Premises, including without limitation, electricity, gas, water, sewer, steam, fire protection, telephone and other
communication services, utilities for heating, ventilating and air-conditioning (“HVAC”), alarm and other security services, pest and rodent control, janitorial, cleaning and trash collection, including ail connection, disconnection and
maintenance charges, deposits, taxes or fees therefor. Landlord reserves the right to designate the companies that shall provide utility services. Notwithstanding the foregoing or any other provision of this Lease to the contrary, Landlord reserves
the right to provide water, sewer, HVAC and other services for the Building or Property, and to require that Tenant pay Tenant’s Share thereof as part of Expenses. 
 B. Intentionally omitted. 
 C. Installation, Connection and Use of
Utility Equipment. Tenant shall install and connect all equipment and lines required to supply such utilities to the extent not already available at or serving the Premises, or at Landlord’s option shall repair, alter or replace any such
existing items (or Tenant shall share the costs thereof for any HVAC unit or other equipment shared with other tenants as described in Article 8). Tenant shall not install any equipment or fixtures, or use the same, so as to exceed the safe and
lawful capacity of any utility equipment or lines serving the same. The maintenance and repair of all such items shall be as further provided in Article 8, and the installation, alteration, replacement or connection of any utility equipment and
lines shall be subject to the requirements for alterations of the Premises set forth in Article 9. Tenant shall ensure that ail HVAC equipment is operated at all times in a manner to prevent roof leaks, damage or noise due to vibrations or improper
installation, maintenance or operation. Tenant shall keep the Premises sufficiently heated to avoid freezing of pipes. 
 D. Interruptions. Landlord shall not be liable in damages or otherwise for any failure or interruption of Tenant’s utilities or services, and Tenant shall not be entitled to terminate this Lease or abate any
portion of the Rent due under the Lease as a result of such failure or interruption. 
 E. Abatement of Rent.
Notwithstanding Paragraph D above to the contrary, if: (a) any services or utilities are interrupted or discontinued as a result of Landlord’s negligence (and not caused by Tenant or its employees, agents or contractors), and Tenant is
unable to and does not use, the Premises as a result of such interruption or discontinuance, and (b) Tenant shall have given written notice respecting such interruption or discontinuance to Landlord, and Landlord shall have failed to cure such
interruption or discontinuance within three (3) consecutive business days after receiving such notice,

  

					
		  	7	  	

 
Base Rent hereunder shall thereafter be abated until such time as such services or utilities are restored or Tenant begins using the Premises again, whichever shall first occur. Notwithstanding
anything to the contrary contained herein, if Tenant, or its contractors, or their respective officers, employees, contractors, invitees or agents, delay Landlord in restoring the utilities or services, Landlord shall have additional time to
complete the restoration equal to such delay and Tenant shall pay Landlord all Rent for the period of such delay. 
 ARTICLE
7: USE, COMPLIANCE WITH LAWS, AND RULES 
 A. Use of Premises. Tenant shall use the Premises only for the permitted
use identified in Article 1, and no other purpose whatsoever, subject to the other provisions of this Article and this Lease. Unless expressly permitted in Article 1, Tenant shall not use or permit the Premises to be used as a:
(i) telemarketing “boiler-room,” or call center operation, (ii) “executive suite” or “legal suite” multi-party shared offices operation, (iii) travel agency or reservation center, (iv) computerized
vehicle sales, loan or “finder” service, (v) social-welfare office or governmental, quasi-governmental, trade association or union office or activities, (vi) employment, placement, recruiting or clerical support agency,
(vii) radio or television studio or broadcasting or recording facility, or (viii) school, educational facility or training center (except for training that is minor and ancillary and does not require parking in excess of code requirements
for the Building). 
 B. Compliance With Laws. Tenant shall comply with all Laws relating to the Premises and
Tenant’s use of the Premises and Property, and shall promptly reimburse Landlord for any expenses Landlord incurs for work or other matters relating to areas outside of the Premises in order to comply with Laws as a result of Tenant’s use
of the Premises or Property; provided, Tenant shall not be required by this provision to perform structural improvements to the Premises that involve a significant capital expenditure and will result in a benefit to Landlord extending beyond the
Term, as it may be extended, unless required by a Law pertaining to: (i) Tenant’s particular use of the Premises (as opposed to a Law that applies to all tenants in general), (ii) Work performed by or for Tenant or any Transferee
(i.e. excluding any improvements or work that Landlord is required to perform under this Lease), or (iii) other acts or omissions of Tenant or any Transferee. 
 C. Rules. Tenant shall comply with the Rules set forth in Exhibit B attached hereto (the “Rules”). Landlord shall have the right, by notice to Tenant, to reasonably amend such
Rules and supplement the same with other reasonable Rules relating to the Property, or the promotion of safety, care, efficiency, cleanliness or good order therein, provided that such new or supplemental rule(s) do not materially decrease
Tenant’s rights under this Lease or materially increase Tenant’s costs or monetary obligations. Tenant shall be required to comply with any such new or amended rules if Tenant receives a copy thereof. Although Landlord shall not
discriminate against Tenant in the enforcement of the Rules, nothing herein shall be construed to give Tenant or any other Person any claim, demand or cause of action against Landlord arising out of the violation of Laws or the Rules by any other
tenant or visitor of the Property, or out of the enforcement, modification or waiver of the Rules by Landlord in any particular instance. 
 D. Other Requirements. So long as Tenant receives written notification of the applicable requirements, Tenant shall not use or permit the Premises or Property to be used in a way that will:
(i) violate the commercially reasonable requirements of Landlord’s insurers, the American Insurance Association, or any board of underwriters, (ii) cause a cancellation of Landlord’s policies, impair the insurability of the
Property, or increase Landlord’s premiums, provided Tenant is given written notice and a reasonable opportunity to alter its use of the Premises to prevent the foregoing (any such increase shall be paid by Tenant, to the extent Landlord
provides Tenant with reasonable evidence that Tenant is responsible for such increase, without such payment being deemed permission to continue such activity or a waiver of any other remedies of Landlord), or (iii) violate the commercially
reasonable requirements of any Lenders, the certificates of occupancy issued for the Premises or the Property, or any other requirements, covenants, conditions or restrictions affecting the Property at any time. 
  

					
		  	8	  	

 ARTICLE 8: MAINTENANCE AND REPAIRS 
 A. Tenant Maintenance and Repairs. Tenant shall keep and maintain the Premises in good and sanitary condition,
working order and repair, in compliance with all applicable Laws as described in Article 7, and as required under other provisions of this Lease (including the Rules), including any carpet and other flooring material, paint and wall-coverings,
entrances, entry and interior doors, windows, ceilings, interior sides of demising walls and all interior walls and partitions, lighting fixtures (including bulbs, tubes and ballasts), refrigeration systems and equipment, interior drainage systems,
plumbing fixtures and equipment, lines for water and sewer exclusively serving the Premises (including free flow up to the common sewer line), dock boards, dock levelers and/or dock bumpers, overhead truck doors, keys and locks, fire extinguishers,
trade fixtures, alterations, improvements, and systems and equipment in or exclusively serving the Premises whether installed by Landlord or Tenant, all subject to normal wear and tear. In the event that any repairs, maintenance or replacements are
required, Tenant shall promptly notify Landlord and arrange for the same either: (i) through Landlord for such reasonable charges as Landlord may establish from time to time, payable within thirty (30) days after billing, or (ii) at
Landlord’s option, by engaging such contractors as Landlord shall first designate or approve in writing to perform such work, all in a first class, workmanlike manner approved by Landlord in advance in writing and otherwise in compliance with
Article 9 respecting “Work”. Tenant shall promptly notify Landlord concerning the necessity for any repairs or other work hereunder and upon completion thereof. Tenant shall pay Landlord for any repairs, maintenance and replacements to
areas of the Property outside the Premises caused, in whole or in part, as a result of moving any furniture, fixtures, or other property to or from the Premises, or otherwise by Tenant or its employees, agents, contractors, or visitors
(notwithstanding anything in this Lease). 
 B. HVAC Maintenance. Tenant shall enter annual, written
HVAC maintenance contracts at Tenant’s sole cost with competent, licensed contractors reasonably approved or designated by Landlord (unless Landlord elects from time to time in writing to make such arrangements directly, in which case, Landlord
may include such costs in Expenses), Such contracts to be entered into by Tenant shall include, and Tenant shall require that such contractors provide: (i) inspection, cleaning and testing at least semi-annually (or more frequently if required
by applicable Law or if reasonably required by Landlord), (ii) any servicing, maintenance, repairs and replacements of filters, belts or other items determined to be necessary or appropriate as a result of such inspections and tests, or by the
manufacturers’ warranty, service manual or technical bulletins, or otherwise required to ensure proper and efficient operation, including emergency work, (iii) all other work as shall be reasonably required by Tenant, Landlord or
Landlord’s insurance carriers, (iv) a detailed record of all services performed, and (v) an annual service report at the end of each calendar year (Tenant shall provide Landlord with a copy of such annual reports promptly upon
Tenant’s receipt thereof). Not later than ten (10) days after the Commencement Date and annually thereafter, Tenant shall provide Landlord with a copy of all maintenance contracts required hereunder, and written evidence reasonably
satisfactory to Landlord that the annual fees therefor have been paid. Such maintenance contracts shall not be deemed to limit Tenant’s general obligations to keep any HVAC equipment and other systems and equipment hereunder in good working
order, repair and condition as further described in Paragraph A, above. 
 Notwithstanding the foregoing, it is understood and
agreed that with respect to the costs of any maintenance, repairs or replacements to the HVAC system which are not covered by the annual maintenance contracts described in the preceding paragraph, any costs in excess of $200 per unit per year shall
be paid by Landlord, unless Landlord elects, at its cost, to replace any unit(s) in which case Tenant shall thereafter be responsible for all costs for such new unit(s). 
 C. Landlord Maintenance and Repairs. Landlord shall keep the roof, roof membrane, foundation, structural components of exterior walls of the Premises, and common areas of the Property, in good and
sanitary condition, working order and repair (the cost of which shall be included in Expenses to the extent permitted in the definition thereof in Article 30). As conditions to Landlord’s repair obligations, Tenant shall give Landlord
reasonable prior notice of the necessity for such repairs, and any damage shall not have been caused by any act or omission of Tenant or any other occupant of the Premises, or any of

  

					
		  	9	  	

 
their employees, agents, invitees or contractors. Notwithstanding the foregoing, for any damage which shall have been caused by any act or omission of Tenant or any other occupant of the
Premises, or any of their employees, agents, invitees or contractors, Landlord shall repair such damage but reserves the right to charge Tenant for the cost of such repair. 
 ARTICLE 9: ALTERATIONS AND LIENS 
 A. Alterations
and Approval. Tenant shall not attach any fixtures, equipment or other items to the Premises, or paint or make any other additions, changes, alterations or improvements to the Premises or the Systems and Equipment serving the Premises (all such
work is referred to collectively herein as the “Work”), without the prior written consent of Landlord. Landlord shall not unreasonably withhold or delay consent, except that Landlord reserves the right to withhold consent in
Landlord’s sole discretion for Work affecting the structure, safety, efficiency or security of the Property or Premises, the Systems and Equipment, or the appearance of the Premises from any common or public areas. Landlord may only require
removal of Work installed by or for Tenant as provided under Article 23. Notwithstanding the foregoing to the contrary, Tenant may perform cosmetic Work in the Premises (i.e. consisting of paint, carpeting and/or wall-coverings), without
Landlord’s consent and without paying Landlord’s fee described below, provided: (i) Tenant shall give reasonable advance notice to, and shall coordinate the scheduling of such Work with, Landlord, (ii) such Work shall not cost
more than $10,000 in the aggregate in any twelve (12) month period, and (iii) such Work shall be subject to all other provisions of this Lease, including, but not limited to, the other provisions of this Article and the Rules attached
hereto as Exhibit B. 
 B. Approval Conditions. Landlord reserves the right to impose reasonable requirements as a
condition of such consent or otherwise in connection with the Work, including requirements that Tenant: (i) use parties contained on Landlord’s approved list (if reputable and available on commercially reasonable terms) or submit for
Landlord’s prior written approval the names, addresses and background information concerning all architects, engineers, contractors, subcontractors and suppliers Tenant proposes to use, (ii) submit for Landlord’s written approval
detailed plans and specifications prepared by licensed and competent architects and engineers, (iii) obtain and post permits, (iv) provide additional insurance, bonds and/or other reasonable security and/or documentation protecting against
damages, liability and liens, (v) use union labor (if failure to use union labor would cause strikes, picketing or other labor disharmony at the Property), (vi) permit Landlord or its representatives to inspect the Work at reasonable
times, and (vii) comply with such other reasonable requirements as Landlord may impose concerning the manner and times in which such Work shall be done. If Landlord consents, inspects, supervises, recommends or designates any architects,
engineers, contractors, subcontractors or suppliers, the same shall not be deemed a warranty as to the adequacy of the design, workmanship or quality of materials, or compliance of the Work with the plans and specifications or any Laws. 

C. Performance of Work. All Work shall be performed: (i) in a thoroughly first class, professional and workmanlike manner,
(ii) only with materials that are new, high quality, and free of material defects, (iii) only by parties, and strictly in accordance with plans, specifications, and other matters/approved or designated by Landlord in advance in writing,
(iv) so as not to adversely affect the Systems and Equipment or the structure of the Property, (v) diligently to completion and so as to avoid any disturbance, disruption or inconvenience to other tenants and the operation of the Property,
and (vi) in compliance with all Laws, the Rules and other provisions of this Lease, and such other reasonable requirements as Landlord may impose concerning the manner and times in which such Work shall be done. Landlord may require that any
floor, wall or ceiling coring work or penetrations OF use of noisy or heavy equipment which may interfere with the conduct of business by other tenants be performed at times other than normal building hours (at Tenant’s sole
cost). If Tenant fails to perform the Work as required herein or the materials supplied fail to comply herewith or with the specifications approved by Landlord, Landlord shall have the right to temporarily stop the applicable portions of the Work
pending Tenant’s cure of such failure. Upon completion of any Work hereunder, Tenant shall provide Landlord with “as built” plans, copies of all construction contracts, and proof of payment for all labor and materials. 
  

					
		  	10	  	

 D. Liens. Tenant shall pay all costs for the Work when due. Tenant shall keep the
Property, Premises and this Lease free from any mechanic’s, materialman’s, architect’s, engineer’s or similar liens or encumbrances, and any claims therefor, or stop or violation notices, in connection with any Work. If
contemplated under applicable statutory procedures, Tenant shall post and record appropriate notices of non-responsibility on behalf of Landlord, and shall give Landlord notice at least ten (10) days prior to the commencement of any Work (or
such additional time as may be necessary under applicable Laws), to afford Landlord the opportunity of posting and recording any other notices of non-responsibility. Tenant shall remove any such claim, lien or encumbrance, or stop or violation
notices of record, by bond or otherwise within thirty (30) days after Landlord provides notice. If Tenant fails to do so, Landlord may pay the amount (or any portion thereof) or take such other action as Landlord deems necessary to remove such
claim, lien or encumbrance, or stop or violation notices, without being responsible for investigating the validity thereof. The amount so paid and costs incurred by Landlord shall be deemed additional Rent under this Lease payable upon demand,
without limitation as to other remedies available to Landlord. Nothing contained in this Lease shall authorize Tenant to do any act that subjects Landlord’s title to, or any Lender’s interest in, the Property or Premises to any such
claims, liens or encumbrances, or stop or violation notices, whether claimed pursuant to statute or other Law or express or implied contract. 
 E. Landlord’s Fees and Costs. Tenant shall pay Landlord a fee for reviewing, scheduling, monitoring, supervising, and providing access for or in connection with the Work, in an amount equal to
three percent (3%) of the total cost of the Work (including costs of plans and permits therefor), and Landlord’s reasonable out-of-pocket costs, including any costs for security, utilities, trash removal, temporary barricades, janitorial
engineering, architectural or consulting services, and other matters in connection with the Work, payable within thirty (30) days after billing; provided, such percentage fee under this Paragraph 9.E shall not apply to minor cosmetic Work
costing less than $10,000, or to the Work under Exhibit C (which shall be governed by the provisions thereof). 
 ARTICLE 10: INSURANCE, SUBROGATION, AND WAIVER OF CLAIMS 
 A. Required Insurance. Tenant shall maintain
during the Term: (i) commercial general liability (“CGL”) insurance, with limits of not less than $1,000,000 for personal injury, bodily injury or death, and property damage or destruction (including loss of use thereof), combined
single limit, for any one occurrence, and $2,000,000 in the aggregate per policy year, with endorsements: (a) for contractual liability covering Tenant’s indemnity obligations under this Lease, and (b) adding Landlord, the management
company for the Property, and other parties reasonably designated by Landlord, as additional insureds, (ii) environmental impact liability insurance (“EIL”) in the amount of at least $1,000,000 per claim (and which shall apply to
claims made during the Term and for a period of at least 12 months thereafter), and (iii) primary, noncontributory, extended coverage or “all-risk” property damage insurance (including installation floater insurance during any
alterations or improvements that Tenant makes to the Premises) covering any alterations or improvements beyond any work or allowance provided by Landlord under this Lease, and Tenant’s personal property, business records, fixtures and
equipment, for damage or other loss caused by fire or other casualty or cause including, but not limited to, vandalism and malicious mischief, theft, water damage of any type, including sprinkler leakage, bursting or stoppage of pipes, explosion,
business interruption (for at least nine (9) months), and other insurable risks for not less than the full insurable replacement value of such property and full insurable value of such other interests of Tenant (subject to reasonable deductible
amounts). Landlord agrees to maintain, as part of Expenses, during the Term, commercial general liability insurance, and property damage insurance on the Property, covering such risks and in such amounts as Landlord shall deem commercially
reasonable, and such other insurance as Landlord shall deem commercially reasonable (subject to such deductibles, self-insurance retention amounts, blanket and umbrella policy arrangements or other features as Landlord deems commercially
reasonable); provided (i) such commercial general liability insurance shall be at least One Million Dollars ($1,000,000.00) per occurrence and Two Million Dollars ($2,000,000.00) general aggregate, and (ii) such property damage insurance
shall cover the Building, and leasehold improvements to the extent provided or paid for by Landlord, and shall be in the amount of full replacement cost, excluding basements, footings and foundations (subject, in each case, to such deductibles,
self-insurance retention amounts, blanket and umbrella policy arrangements or other features as Landlord deems commercially reasonable). 
  

					
		  	11	  	

 B. Certificates and Other Matters. Tenant shall provide Landlord with certificates
evidencing the coverage required hereunder prior to the Commencement Date. Such certificates shall state that such insurance coverage may not be reduced, canceled or allowed to expire without at least thirty (30) days’ prior written notice
to Landlord, and shall include, as attachments, originals of the additional insured endorsements to Tenant’s CGL policy required above. Tenant shall provide renewal certificates to Landlord at least thirty (30) days prior to expiration of
such policies. Except as provided to the contrary herein, any insurance carried by Landlord or Tenant shall be for the sole benefit of the party carrying such insurance. Tenant’s insurance policies shall be primary to all policies of Landlord
and any other additional insureds (whose policies shall be deemed excess and non-contributory). All insurance required hereunder shall be provided by responsible insurers licensed in the State in which the Property is located, and shall have a
general policy holder’s rating of at least A- and a financial rating of at least X in the then current edition of Best’s Insurance Reports. Landlord disclaims any representation as to whether the foregoing coverages will be adequate to
protect Tenant. 
 C. Mutual Waiver of Claims and Subrogation. The parties hereby mutually waive all claims against each
other for all losses covered or required to be covered hereunder by their respective insurance policies, and waive all rights of subrogation of their respective insurers; for purposes hereof, any deductible amount shall be treated as though it were
recoverable under such policies. SUCH MUTUAL WAIVER OF CLAIMS SHALL APPLY REGARDLESS OF THE NEGLIGENCE OF THE OTHER PARTY OR ITS AFFILIATES, AGENTS OR EMPLOYEES. The parties agree that their respective insurance policies are now, or shall be,
endorsed such that said waiver of subrogation shall not affect the right of the insured to recover thereunder. 
 ARTICLE 11:
CASUALTY DAMAGE 
 A. Restoration. Tenant shall promptly notify Landlord of any damage to the Premises by fire or
other casualty. If the Premises or any common areas of the Property providing access thereto shall be damaged by fire or other casualty, Landlord shall use available insurance proceeds to restore the same. Such restoration shall be to substantially
the same condition as prior to the casualty, except for modifications required by zoning and building codes and other Laws or by any Lender, any other modifications to the common areas deemed desirable by Landlord (provided access to the Premises is
not materially impaired), and except that Landlord shall not be required to repair or replace any of Tenant’s furniture, furnishings, fixtures, systems or equipment, or any alterations or improvements in excess of any work or allowance provided
by Landlord under this Lease. Tenant shall reasonably cooperate in approving any plans for repairs to the Premises hereunder, and in vacating the Premises to the extent reasonably required to avoid any interference or delay in Landlord’s repair
work. Promptly following completion of Landlord’s work, Tenant shall repair and replace Tenant’s furniture, furnishings, fixtures, systems or equipment, and any alterations or improvements made by Tenant in excess of those provided by
Landlord, subject to and in compliance with the other provisions of this Lease. 
 B. Abatement of Rent. Landlord shall
not be liable for any inconvenience or annoyance to Tenant or its visitors, or injury to Tenant’s business resulting in any way from such damage or the repair thereof. However, Landlord shall allow Tenant a proportionate abatement of Rent from
the date of the casualty through the date that Landlord substantially completes Landlord’s repair obligations hereunder (or the date that Landlord would have substantially completed such repairs, but for delays by Tenant or any other Person
occupying the Premises through or under Tenant, or any of their agents, employees, invitees, Transferees and contractors), provided such abatement shall apply only to the extent the Premises are untenantable for the purposes permitted under this
Lease and not used by Tenant as a result thereof, based proportionately on the square footage of the Premises so affected and not used. 
  

					
		  	12	  	

 C. Termination of Lease by Landlord. Notwithstanding the foregoing to the contrary,
in lieu of performing the restoration work, Landlord may elect to terminate this Lease by notifying Tenant in writing of such termination within ninety (90) days after the date of damage (such termination notice to include a termination date
providing at least thirty (30) days for Tenant to vacate the Premises), if the Property shall be materially damaged by the intentional misconduct of Tenant or its Transferees or their respective agents, employees or contractors, or if the
Property shall be damaged by fire or other casualty or cause such that: (i) repairs to the Premises and access thereto cannot reasonably be completed within 120 days after the casualty without the payment of overtime or other premiums,
(ii) more than twenty-five percent (25%) of the Premises is affected by the damage and fewer than twenty-four (24) months remain in the Term, or any material damage occurs to the Premises during the last twelve (12) months of the
Term, (iii) any Lender shall require that the insurance proceeds or any material portion thereof be used to retire the Mortgage debt (or shall terminate the ground lease, as the case may be), or the damage is not fully covered, except for
reasonable deductible amounts, by Landlord’s insurance policies, or (iv) the cost of the repairs, alterations, restoration or improvement work would exceed thirty-five percent (35%) of the replacement value of the Building (whether or
not the Premises are affected by the damage). Tenant agrees that the abatement of Rent provided herein shall be Tenant’s sole recourse in the event of such damage, and waives any other rights Tenant may have under any applicable Law to perform
repairs or terminate the Lease by reason of damage to the Premises or Property, except as provided in Section D below. 
 D.
Termination of Lease By Tenant. Notwithstanding Paragraph C above to the contrary, Tenant may terminate this Lease if Tenant is unable to use all or a substantial portion of the Premises as a result of fire or other casualty not caused by Tenant
or its employees or agents, and: (i) Landlord fails to commence the restoration work within forty-five (45) days after the damage occurs, or (ii) such work is estimated (which estimate Landlord shall provide within sixty
(60) days following the casualty), to take more than 120 days to substantially complete after being commenced, or (iii) Landlord fails to substantially complete such work within 120 days after commencing the same, or (iv) more than
25% of the Premises is affected by the damage, and fewer than 12 months remain in the Term. In order to exercise any of the foregoing termination rights, Tenant must send Landlord at least thirty (30) days (but not more than 120 days) advance
notice specifying the basis for termination, and such notice must be given no later than fifteen (15) days following the occurrence of the condition serving as the basis for the termination right invoked by Tenant. Such termination rights shall
not be available to Tenant if: (a) Landlord substantially completes the repairs to the Premises and access thereto within fifteen (15) days after Tenant’s notice, or (b) Landlord provides Tenant with new premises under Article 20
or otherwise and access thereto within thirty (30) days after Tenant’s notice. Notwithstanding anything to the contrary contained herein, if Tenant, or its officers, employees, contractors, invitees or agents delay Landlord in performing
the repairs, Landlord shall have additional time to complete the work equal to such delay and Tenant shall pay Landlord all Rent for the period of such delay. 
 ARTICLE 12: CONDEMNATION 
 If at least twenty-five percent (25%) of
the rentable area of the Premises shall be taken by power of eminent domain or condemned by a competent authority or by conveyance in lieu thereof for public or quasi-public use (“Condemnation”), including any temporary taking for a period
of one year or longer, then either Landlord or Tenant may elect to terminate this Lease effective on the date possession for such use is so taken, by giving notice to the other party no later than one hundred and twenty (120) days after
receiving notice of the filing of the Condemnation. If: (i) less than the foregoing amount of the Premises is taken, but the taking includes or affects a material portion of the Building or Property, or Landlord’s economical operation
thereof, or (ii) the taking is temporary and will be in effect for less than the foregoing period but more than thirty (30) days, then in either such event, Landlord may elect to terminate this Lease upon at least thirty
(30) days’ prior notice to Tenant. The parties further agree that: (a) if this Lease is terminated, all Rent shall be apportioned as of the date of such termination or the date of such taking, whichever shall first occur, (b) if
the taking is temporary, Rent shall be abated for the period of the taking, and Landlord may seek a condemnation award therefor (and the Term shall not be extended thereby), and (c) if this Lease is not terminated but any part of the Premises
is permanently taken, the Rent shall be proportionately abated based on the square footage of the Premises so taken. Landlord shall be entitled to receive the entire award or payment in connection with such Condemnation

  

					
		  	13	  	

 
and Tenant hereby assigns to Landlord any interest therein for the value of Tenant’s unexpired leasehold estate or any other claim and waives any right to participate therein, except that
Tenant shall have the right to file any separate claim available to Tenant for moving expenses and any taking of Tenant’s personal property, provided such award is separately payable to Tenant and does not diminish the award available to
Landlord or any Lender. 
 ARTICLE 13: ASSIGNMENT AND SUBLETTING 
 A. Transfers. Tenant shall not, without the prior written consent of Landlord, which consent shall not be unreasonably withheld as
further described below: (i) assign, mortgage, pledge, hypothecate, encumber, or permit any lien to attach to, or otherwise transfer, this Lease or any interest hereunder, by operation of Law or otherwise, (ii) sublet the Premises or any
part thereof, or (iii) permit the use of the Premises by any Persons other than Tenant and its employees (all of the foregoing are hereinafter sometimes referred to collectively as “Transfers” and any Person to whom any Transfer is
made or sought to be made is hereinafter sometimes referred to as a “Transferee”). If Tenant shall desire Landlord’s consent to any Transfer, Tenant shall notify Landlord in writing, which notice shall include: (a) the proposed
effective date (which shall not be less than thirty (30) nor more than 180 days after Tenant’s notice), (b) the portion of the Premises to be Transferred (herein called the “Subject Space”), (c) the terms of the
proposed Transfer and the consideration therefor, the name, address and background information concerning the proposed Transferee, and a true and complete copy of all proposed Transfer documentation, (d) financial statements (balance sheets and
income/expense statements for the current and prior year) of the proposed Transferee, in form and detail reasonably satisfactory to Landlord, certified by an officer, partner or owner of the Transferee, or (e) any other reasonable information
to enable Landlord to determine the financial responsibility, character, and reputation of the proposed Transferee, nature of such Transferee’s business and proposed use of the Subject Space or as Landlord may reasonably request. Any Transfer
made without complying with this Article shall, at Landlord’s option, be null, void and of no effect, or shall constitute a Default under this Lease. Whether or not Landlord shall grant consent, Tenant shall pay $500 towards Landlord’s
review and processing expenses, as well as any reasonable legal fees incurred by Landlord, within thirty (30) days after Landlord’s written request (provided, Landlord’s current policy is to handle such matters with in-house counsel,
to the extent that the in-house staff has time, in which case no legal fees will be charged). 
 B. Approval. Landlord
will not unreasonably withhold its consent to any proposed Transfer of the Subject Space to the Transferee on the terms specified in Tenant’s notice. The parties hereby agree that it shall be reasonable under this Lease and under any applicable
Law for Landlord to withhold consent to any proposed Transfer where one or more of the following applies (without limitation as to other reasonable grounds for withholding consent): (i) the Transferee is of a character or reputation or engaged
in a business which is not consistent with the quality or nature of the Property or other tenants of the Property, (ii) the Transferee intends to use the Subject Space for purposes which are not permitted under this Lease, would result in more
than a reasonable number of occupants, or would require increased services by Landlord, (iii) the Subject Space is not regular in shape with appropriate means of ingress and egress suitable for normal renting purposes in compliance with Laws,
(iv) the Transferee is a government, or agency or instrumentality thereof, (v) the Transferee or any affiliate thereof is an occupant of the Property (or of any complex in which the Property is located) or has negotiated to lease space in
the Property (or in such complex) from Landlord during the prior four (4) months (unless Landlord is unable to provide office space of the approximate number of square feet of rentable area (plus or minus ten percent) required by such party at
the Property (or in such complex), and Tenant can provide such size space within the Premises), (vi) the Transferee does not have, in Landlord’s good faith determination, satisfactory references or a reasonable financial condition in
relation to the obligations to be assumed in connection with the Transfer, (vii) the Transfer involves a partial or collateral assignment, mortgage or other encumbrance on this Lease, a sub-sublease or assignment of a sublease, (viii) the
Transfer would cause Landlord to be in violation of any Laws or any other lease, Mortgage or agreement to which Landlord is a party, or would give a tenant of the Property a right to cancel its lease, or (ix) Tenant has committed and failed to
cure a Default. If Tenant disagrees with Landlord’s decision to deny approval, Tenant’s sole remedy shall be to seek immediate declaratory and injunctive relief, and to recover attorneys’ fees and costs as a prevailing party under
Article 17. 
  

					
		  	14	  	

 C. Transfer Premiums. If Landlord consents to a Transfer, and as a condition thereto
which the parties hereby agree is reasonable, Tenant shall retain fifty percent (50%) of any Transfer Premium, and shall pay Landlord fifty percent (50%) of any Transfer Premium, derived by Tenant from such Transfer. “Transfer
Premium” shall mean: (i) for a lease assignment, all consideration paid or payable therefor, and (ii) for a sublease, all rent, additional rent or other consideration paid by such Transferee in excess of the Rent payable by Tenant
under this Lease (on a monthly basis during the Term, and on a per rentable square foot basis, if less than all of the Premises is transferred). In any such computation, Tenant: (a) may subtract any reasonable direct out-of-pocket costs
incurred in connection with such Transfer, such as advertising costs, brokerage commissions, attorneys’ fees and leasehold improvements for the Subject Space, and (b) shall include in the “Transfer Premium” any so-called
“key money” or other bonus amount paid by Transferee to Tenant, and any payments in excess of fair market value for services rendered by Tenant to Transferee or in excess of fair market value for assets, fixtures, inventory, equipment or
furniture transferred by Tenant to Transferee. Tenant shall pay the percentage of the Transfer Premium due Landlord within thirty (30) days after Tenant receives any Transfer Premium. 
 D. Recapture. Notwithstanding anything to the contrary contained in this Article, Landlord shall have the option, by giving notice to
Tenant within thirty (30) days after receipt of Tenant’s notice of any proposed Transfer, to recapture the Subject Space. Such recapture notice shall cancel and terminate this Lease with respect to the Subject Space, as the case may be, as
of the date stated in Tenant’s notice as the effective date of the proposed Transfer (or at Landlord’s option, such notice shall cause the Transfer to be made to Landlord or its agent or nominee, in which case the parties shall execute
reasonable Transfer documentation promptly thereafter). If this Lease shall be canceled with respect to less than the entire Premises, the Rent herein shall be prorated on the basis of the number of rentable square feet retained by Tenant in
proportion to the number of rentable square feet contained in the Premises, this Lease as so amended shall continue thereafter in full force and effect, and upon request of either party the parties shall execute written confirmation of the same.
Tenant shall surrender and vacate the Subject Space when required hereunder in accordance with Article 23, and any failure to do so shall be subject to Article 24. Notwithstanding the foregoing to the contrary, Landlord’s recapture rights
hereunder shall not apply with respect to any sublease: (a) to a Tenant Affiliate as hereinafter defined, or (b) to a non-Tenant Affiliate where Tenant is not, and will not as a result of such sublease, be subleasing more than thirty
percent (30%) of the rentable area of the Premises, in the aggregate, to non- Tenant Affiliates, unless: (i) the sublease for a non-Tenant Affiliate is for a term that will be in effect during all or most of the remainder of the then
current term of this Lease, or (ii) fewer than twelve (12) months will then remain in the Term on the commencement date of such sublease for the non-Tenant Affiliate. The term “ Tenant Affiliate “ as used herein shall mean any
party which directly or indirectly: (i) wholly owns or controls Tenant, (ii) is wholly owned or controlled by Tenant, or (iii) is under common ownership or control with Tenant, or (iv) into which Tenant is merged, consolidated or
reorganized, or to which all or substantially all of Tenant’s assets are sold. 
 E. Terms of Consent. If Landlord
consents to a Transfer: (i) the terms and conditions of this Lease, including Tenant’s liability for the Subject Space, shall in no way be deemed to have been waived or modified, (ii) such consent shall not be deemed consent to any
further Transfer by either Tenant or a Transferee, (iii) no Transferee shall succeed to any rights provided in this Lease or any amendment hereto to extend the Term of this Lease, expand the Premises, or lease other space, any such rights being
deemed personal to the initial Tenant, (iv) Tenant shall deliver to Landlord, promptly after execution, an original executed copy of all documentation pertaining to the Transfer in form reasonably acceptable to Landlord, and (v) Tenant
shall furnish a statement setting forth in detail the computation of any Transfer Premium that Tenant has derived and shall derive from such Transfer. Landlord or its representatives shall have the right at reasonable times to audit the books,
records and papers of Tenant and any Transferee relating to any Transfer, and to make copies thereof. If a Transfer Premium is found understated, Tenant shall pay the deficiency within thirty (30) days after billing (and if understated by more
than five percent (5%), Tenant shall include with such payment Landlord’s reasonable costs of such audit). Any sublease hereunder shall be subordinate and subject to the

  

					
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provisions of this Lease, and if this Lease shall be terminated during the term of any sublease, whether based on Default or mutual agreement, Landlord shall have the right to: (a) deem such
sublease as merged and canceled and repossess the Subject Space by any lawful means, or (b) require that such subtenant attorn to and recognize Landlord as its landlord under such sublease with respect to obligations arising thereafter, subject
to the terms of Landlord’s standard form of attornment documentation. If Tenant shall commit a Default under this Lease, Landlord is hereby irrevocably authorized to direct any Transferee to make all payments under or in connection with the
Transfer directly to Landlord (which Landlord shall apply toward Tenant’s obligations under this Lease). 
 F. Certain
Transfers. For purposes of this Lease, the term ‘Transfer” shall also include, and all of the foregoing provisions shall apply to: (i) the conversion, merger or consolidation of Tenant into a limited liability company or limited
liability partnership, (ii) if Tenant is a partnership or limited liability company, the withdrawal or change, voluntary, involuntary or by operation of law, of a majority of the partners or members, or a transfer of a majority of partnership
or membership interests, within a twelve month period, or the dissolution of the partnership or company, and (iii) if Tenant is a closely held corporation (i.e., whose stock is not publicly held and not traded through an exchange or over the
counter), the dissolution, merger, consolidation or other reorganization of Tenant, or within a twelve month period: (a) the sale or other transfer of more than an aggregate of 50% of the voting shares of Tenant (other than to immediate family
members by reason of gift or death) or (b) the sale, mortgage, hypothecation or pledge of more than an aggregate of 50% of Tenant’s net assets. Notwithstanding the foregoing to the contrary, a transaction described in this Article 13.F
shall not be deemed to be a Transfer requiring Landlord’s consent so long as, after the transaction, Tenant or the surviving entity (as the case may be) shall own all or substantially all of the business and assets of Tenant (including the
assignment of this Lease to and assumption of this Lease by any such surviving entity) and so long as such transaction is not for the express purpose of avoiding Landlord’s consent but is made in good faith for bona fide business reasons of
Tenant. 
 ARTICLE 14: PERSONAL PROPERTY, RENT AND OTHER TAXES 
 Tenant shall pay, prior to delinquency, all taxes, charges or other governmental impositions assessed against or levied upon all fixtures,
furnishings, personal property, built-in and modular furniture, and systems and equipment located in or exclusively serving the Premises, notwithstanding that certain such items may become Landlord’s property under Article 23 upon termination
of the Lease. Whenever possible, Tenant shall cause all such items to be assessed and billed separately from the other property of Landlord. In the event any such items shall be assessed and billed with the other property of Landlord, Tenant shall
pay Landlord Tenant’s share of such taxes, charges or other governmental impositions within thirty (30) days after Landlord delivers a statement and a copy of the assessment or other documentation showing the amount of impositions
applicable to Tenant’s property. Tenant shall pay any rent tax, sales tax, service tax, transfer tax, value added tax, or any other applicable tax on the Rent, utilities or services herein, the privilege of renting, using or occupying the
Premises or collecting Rent therefrom, or otherwise respecting this Lease or any other document entered in connection herewith, but shall not be required to pay any income tax of Landlord. 
 ARTICLE 15: LANDLORD’S REMEDIES 
 A.
Default. The occurrence of any one or more of the following events shall constitute a “Default” by Tenant and shall give rise to Landlord’s remedies set forth in Paragraph B below: (i) failure to make when due any payment of
Rent, unless such failure is cured within ten (10) days after notice; (ii) failure to observe or perform any term or condition of this Lease other than the payment of Rent (or the other matters expressly described herein), unless such
failure is cured within any period of time following notice expressly provided with respect thereto in other Articles hereof, or otherwise within a reasonable time, but in no event more than thirty (30) days following notice (provided, if the
nature of Tenant’s failure is such that more time is reasonably required in order to cure, Tenant shall not be in Default if Tenant commences to cure promptly within such period, and diligently seeks and keeps Landlord reasonably

  

					
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advised of efforts to cure such failure to completion); (iii) failure to cure immediately upon notice thereof any condition which is hazardous, interferes with another tenant or the
operation or leasing of the Property, or may cause the imposition of a fine, penalty or other remedy on Landlord or its agents or affiliates, (iv) violating Article 13 respecting Transfers, or abandoning the Premises (“abandonment”
under this Lease shall mean vacating or failing to occupy the Premises for more than thirty (30) days while Tenant is in Default for failure to pay Rent), or (v) (a) making by Tenant or any guarantor of this Lease
(“Guarantor”) of any general assignment for the benefit of creditors, (b) filing by or for reorganization or arrangement under any Law relating to bankruptcy or insolvency (unless, in the case of a petition filed against Tenant or
such Guarantor, the same is dismissed within thirty (30) days), (c) appointment of a trustee or receiver to take possession of substantially all of Tenant’s assets located in the Premises or of Tenant’s interest in this Lease,
where possession is not restored to Tenant within thirty (30) days, (d) attachment, execution or other judicial seizure of substantially all of Tenant’s assets located in the Premises or of Tenant’s interest in this Lease,
(e) Tenant’s or any Guarantor’s convening of a meeting of its creditors or any class thereof for the purpose of effecting a moratorium upon or composition of its debts, (f) Tenant’s or any Guarantor’s insolvency or
failure, or admission of an inability, to pay debts as they mature, or (g) a violation by Tenant or any affiliate of Tenant under any other lease or agreement with Landlord or any affiliate thereof which is not cured within the time permitted
for cure thereunder. The notice and cure periods herein are intended to satisfy and run concurrently with any notice and cure periods provided by Law, and shall not be in addition thereto. 
 B. Remedies. If a Default occurs, Landlord shall have the rights and remedies hereinafter set forth to the extent permitted by Law:

 (1) Landlord may in accordance with applicable Law terminate Tenant’s right of possession, peaceably reenter and
repossess the Premises by detainer suit, summary proceedings or other lawful means, with or without terminating this Lease (except as required by Law), and recover from Tenant: (i) any unpaid Rent as of the termination date, (ii) the
amount by which: (a) any unpaid Rent which would have accrued after the termination date during the balance of the Term exceeds (b) the reasonable rental value of the Premises under a lease substantially similar to this Lease, taking into
account, among other things, the condition of the Premises, market conditions, the period of time the Premises may reasonably remain vacant before Landlord is able to re-lease the same to a suitable replacement tenant, and Costs of Reletting (as
defined in Paragraph G below) that Landlord may incur in order to enter into such replacement lease, and (iii) any other amounts necessary to compensate Landlord for all damages proximately caused by Tenant’s failure to perform its
obligations under this Lease. For purposes of computing the amount of Rent that would have accrued after the termination date, Tenant’s obligations for Taxes, Insurance and Expenses shall be projected based on the average increase from the
Commencement Date through the termination date. The amounts computed in accordance with the foregoing subclauses (a) and (b) shall be discounted in accordance with accepted financial practice at five percent (5%) per annum to the then
present value. 
 (2) Landlord may in accordance with applicable Law terminate Tenant’s right of possession, peaceably
reenter and repossess the Premises by detainer suit, summary proceedings or other lawful means, with or without terminating this Lease (except as required by Law), and recover from Tenant: (i) any unpaid Rent as of the date possession is
terminated, (ii) any unpaid Rent which thereafter accrues during the Term from the date possession is terminated through the time of judgment (or which may have accrued from the time of any earlier judgment obtained by Landlord), less any
consideration received from replacement tenants as further described and applied pursuant to Paragraph G, below, and (iii) any other amounts necessary to compensate Landlord for all damages proximately caused by Tenant’s failure to perform
its obligations under this Lease, including all Costs of Reletting (as defined in Paragraph G below). Tenant shall pay any such amounts to Landlord as the same accrue or after the same have accrued from time to time upon demand. At any time after
terminating Tenant’s right to possession as provided herein, Landlord may terminate this Lease as provided in clause (1) above by notice to Tenant and may pursue such other remedies as may be available to Landlord under this Lease or Law.

  

					
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 C. Mitigation of Damages. If Landlord terminates this Lease or Tenant’s right to
possession, Landlord shall use reasonable efforts to mitigate Landlord’s damages, and Tenant may submit proof of such failure to mitigate as a defense to Landlord’s claims for Rent, subject to the following clarifications:
(i) Landlord shall not be required to use greater efforts or lower standards than Landlord generally uses to lease other space at the Property, (ii) Landlord will not have failed to mitigate if Landlord or its affiliates lease other
portions of the Property or other projects in the vicinity before reletting the Premises, provided that Landlord shall not discriminate against the Premises in its re-letting efforts, (iii) any failure to mitigate during any period shall reduce
the Rent and other amounts to which Landlord is entitled by the reasonable rental value of the Premises during such period taking into account the factors described in clause B(1) above, (iv) in recognition that the value of the Property
depends on the rental rates and terms of leases therein, Landlord’s rejection of a prospective replacement tenant based on an offer of rentals below the then-current fair market rent for new leases of comparable space at the Property, as
reasonably determined by Landlord, shall not constitute a failure to mitigate, and (v) until Landlord terminates this Lease or Tenant’s right to possession, Landlord shall have no obligation to mitigate and may permit the Premises to
remain vacant or abandoned; in such case, Tenant may seek to mitigate damages by attempting to sublease the Premises or assign this Lease pursuant to Article 13. 
 D. Reletting. If this Lease or Tenant’s right to possession is terminated in accordance with the terms of this Lease, or Tenant abandons the Premises, Landlord may: (i) peaceably enter
and secure the Premises, change the locks, install barricades, remove any improvements, fixtures or other property of Tenant therein, perform any decorating, remodeling, repairs, alterations, improvements or additions and take such other actions as
Landlord shall determine in Landlord’s sole discretion to prevent damage or deterioration to the Premises or prepare the same for reletting, and (ii) relet all or any portion of the Premises (separately or as part of a larger space), for
any rent, use or period of time (which may extend beyond the Term hereof), and upon any other terms as Landlord shall determine in Landlord’s sole discretion, directly or as Tenant’s agent (if permitted or required by applicable Law). The
consideration received from such reletting shall be applied pursuant to the terms of Paragraph G hereof, and if such consideration, as so applied, is not sufficient to cover all Rent and damages to which Landlord may be entitled hereunder, Tenant
shall pay any deficiency to Landlord as the same accrues or after the same has accrued from time to time upon demand, subject to Paragraph C and the other provisions hereof. 
 E. Late Charges, Interest, and Returned Checks. Tenant shall pay, as additional Rent, a service charge of Two Hundred Fifty Dollars
($250.00) or five percent (5%) of the delinquent amount, whichever is greater, if any portion of Rent is not received within ten (10) days after due. Any Rent not paid within thirty (30) days after due shall also accrue interest from
the due date at the Default Rate until paid. Such service charges and interest payments shall not be consent by Landlord to late payments, nor a waiver of Landlord’s right to insist upon timely payments at any time, nor a waiver of any remedies
to which Landlord is entitled as a result of the late payment of Rent. If Landlord receives two (2) or more checks that are returned by Tenant’s bank for insufficient funds, Landlord may require that all checks thereafter be bank certified
or cashier’s checks (without limiting Landlord’s other remedies). All bank service charges resulting from any returned checks shall be borne by Tenant. Notwithstanding the foregoing to the contrary, Landlord shall not impose late charges
on the first late payment in any period of twelve (12) consecutive full calendar months; provided, this limitation on late charges is granted as a special accommodation and a personal right, and shall no longer apply in the event of any
assignment of this Lease. 
 F. Other Remedies. If Tenant fails to perform any obligation within the time required under
this Lease (including any applicable notice and cure period hereunder except in emergencies), Landlord shall have the right (but not the duty), to perform such obligation on behalf and for the account of Tenant. In such event, Tenant shall reimburse
Landlord upon demand, as additional Rent, for all expenses incurred by Landlord in performing such obligation together with an amount equal to ten percent (10%) thereof for Landlord’s overhead, and interest thereon at the Default Rate from
the date such expenses were incurred. Landlord’s performance of Tenant’s obligations hereunder shall not be deemed a waiver or release of Tenant therefrom. Landlord’s remedies set forth above are distinct, separate and cumulative with
and in addition to any other right or remedy allowed under any Law or other provision of this Lease. Without limiting the generality of the foregoing, Landlord shall at all times have the right without prior demand or notice except as required by
applicable Law to: (i) seek any declaratory, injunctive or other equitable relief, and specifically enforce this Lease or restrain or enjoin a violation of any provision hereof, and (ii) sue for and collect any unpaid Rent which has
accrued. 
  

					
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 G. Other Matters. No re-entry or repossession, repairs, changes, alterations and
additions, reletting, or any other action or omission by Landlord shall be construed as an election by Landlord to terminate this Lease or Tenant’s right to possession, nor shall the same operate to release Tenant in whole or in part from any
of Tenant’s obligations hereunder, unless express notice of such intention is sent by Landlord to Tenant (and if applicable Law permits, and Landlord shall not have expressly terminated this Lease in writing, then any termination shall be
deemed a termination of Tenant’s right of possession only). Landlord may bring suits for amounts owed by Tenant hereunder or any portions thereof, as the same accrue or after the same have accrued, and no suit or recovery of any portion due
hereunder shall be deemed a waiver of Landlord’s right to collect all amounts to which Landlord is entitled hereunder, nor shall the same serve as any defense to any subsequent suit brought for any amount not theretofore reduced to judgment.
Landlord may pursue one or more remedies against Tenant and need not make an election of remedies until findings of fact are made by a court of competent jurisdiction. All rent and other consideration paid by any replacement tenants shall be applied
at Landlord’s option: (i) first, to the Costs of Reletting, (ii) second, to the payment of all costs of enforcing this Lease against Tenant or any Guarantor, (iii) third, to the payment of all interest and service charges
accruing hereunder, (iv) fourth, to the payment of Rent theretofore accrued, and (v) with the residue, if any, to be held by Landlord and applied to the payment of Rent and other obligations of Tenant as the same become due (and with any
remaining residue to be retained by Landlord). “Costs of Reletting” shall include all reasonable costs and expenses incurred by Landlord for any repairs or other matters described in Paragraph D above, brokerage commissions, advertising
costs, reasonable attorneys’ fees, and any other costs and incentives incurred in order to enter into leases with replacement tenants. Landlord shall be under no obligation to observe or perform any provision of this Lease on its part to be
observed or performed which involves the payment of money by Landlord to Tenant, or the performance of alterations or improvements to the Premises, while Tenant is in Default hereunder. Tenant agrees that the notice and cure rights set forth herein
contain the entire agreement of the parties respecting such matters, and hereby waives any right otherwise available under any Law to redeem or reinstate this Lease or Tenant’s right to possession after this Lease or Tenant’s right to
possession is properly terminated hereunder. 
 ARTICLE 16: SECURITY DEPOSIT 
 Tenant shall deposit with Landlord the amount set forth in Article 1 (“Security Deposit”), upon Tenant’s execution and
submission of this Lease. The Security Deposit shall serve as security for the prompt, full and faithful performance by Tenant of the provisions of this Lease. If Tenant commits a Default, or owes any amounts to Landlord upon the expiration or
earlier termination of this Lease (including estimated amounts under Article 3, which shall remain subject to reconciliation against actual amounts as further provided therein), Landlord may use or apply the whole or any part of the Security Deposit
for the payment of Tenant’s obligations hereunder. The use or application of the Security Deposit or any portion thereof shall not prevent Landlord from exercising any other right or remedy provided hereunder or under any Law and shall not be
construed as liquidated damages. In the event the Security Deposit is reduced by such use or application, Tenant shall deposit with Landlord within ten (10) days after notice, an amount sufficient to restore the full amount of the Security
Deposit. Landlord shall not be required to keep the Security Deposit separate from Landlord’s general funds or pay interest on the Security Deposit. Any remaining portion of the Security Deposit not used or applied hereunder shall be returned
to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest in this Lease) within sixty (60) days after Tenant (or such assignee) has vacated the Premises in accordance with Article 23. If the Premises shall be
expanded at any time, or if the Term shall be extended at an increased rate of Rent, the Security Deposit shall thereupon be proportionately increased. Tenant shall not assign, pledge or otherwise transfer any interest in the Security Deposit except
as part of an assignment of this Lease approved by Landlord under Article 13, and any attempt to do so shall be null and void. 
  

					
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 ARTICLE 17: ATTORNEYS’ FEES AND VENUE 
 In the event of any litigation or arbitration between the parties relating to this Lease, the Premises or Property (including pretrial,
trial, appellate, administrative, bankruptcy or insolvency proceedings), the prevailing party shall be entitled to recover its reasonable attorneys’ fees and costs as part of the judgment, award or settlement therein. In the event of a breach
of this Lease by either party which does not result in litigation but which causes the non-breaching party to incur attorneys’ fees or costs, the breaching party shall reimburse such reasonable fees and costs to the non-breaching party upon
demand. If either party or any of its officers, directors, trustees, beneficiaries, partners, agents, affiliates or employees shall be made a party to any litigation or arbitration commenced by or against the other party and is not at fault, the
other party shall pay all reasonable attorneys’ fees and costs incurred by such parties in connection with such litigation. Any action or proceeding brought by either party against the other for any matter arising out of or in any way relating
to this Lease, the Premises or the Property, shall be heard, at Landlord’s option, in the court having jurisdiction located closest to the Property. 
 ARTICLE 18: SUBORDINATION, ATTORNMENT AND LENDER PROTECTION 
 Landlord
represents that there is no Mortgage encumbering the Property as of the date of this Lease. This Lease is subject and subordinate to all Mortgages hereafter placed upon the Property, and all other encumbrances and matters of public record applicable
to the Property; provided, this Lease shall only be subordinate to Mortgages made hereafter if the Lenders thereunder agree to enter into their standard forms of subordination, non-disturbance and attornment agreement with Tenant. Whether before or
after any foreclosure or power of sale proceedings are initiated or completed by any Lender or a deed in lieu is granted (or any ground lease is terminated), Tenant agrees, upon written request of any such Lender or any purchaser at such sale, to
attorn and pay Rent to such party, and recognize such party as Landlord (provided such Lender or purchaser shall agree not to disturb Tenant’s occupancy so long as Tenant does not Default hereunder, on a form of agreement customarily used by,
or otherwise reasonably acceptable to, such party). However, in the event of attornment, no Lender shall be: (i) liable for any act or omission of Landlord, or subject to any offsets or defenses which Tenant might have against Landlord (arising
prior to such Lender becoming Landlord under such attornment), (ii) liable for any security deposit or bound by any prepaid Rent not actually received by such Lender, or (iii) bound by any modification of this Lease not consented to by
such Lender. Any Lender may elect to make this Lease prior to the lien of its Mortgage by written notice to Tenant, and if the Lender of any prior Mortgage shall require, this Lease shall be prior to any subordinate Mortgage; such elections shall be
effective upon written notice to Tenant, or shall be effective as of such earlier or later date set forth in such notice. Tenant agrees to give any Lender by certified mail, return receipt requested, a copy of any notice of default served by Tenant
upon Landlord, provided that prior to such notice Tenant has been notified in writing (by way of service on Tenant of a copy of an assignment of leases, or otherwise) of the address of such Lender. Tenant further agrees that if Landlord shall have
failed to cure such default within the time permitted Landlord for cure under this Lease, any such Lender whose address has been provided to Tenant shall have an additional period of thirty (30) days in which to cure (or such additional time as
may be required due to causes beyond such Lender’s reasonable control, including time to obtain possession of the Property by appointment of receiver, power of sale or judicial action; provided, such Lender cure period shall not affect
Tenant’s express rights under this Lease, including Tenant’s rights to abate Rent and/or terminate this Lease under Articles 6.E, 11.B, 11.D and 12). Except as expressly provided to the contrary herein, the provisions of this Article shall
be self-operative; however Tenant shall execute and deliver, within ten (10) days after request therefor, such documentation as Landlord or any Lender may request from time to time, whether prior to or after a foreclosure or power of sale
proceeding is initiated or completed, a deed in lieu is delivered, or a ground lease is terminated, in order to further confirm or effectuate the matters set forth in this Article in recordable form. 
  

					
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 ARTICLE 19: ESTOPPEL CERTIFICATES 
 Tenant shall from time to time, within ten (10) business days after written request from Landlord, execute, acknowledge and deliver a
statement certifying (subject to such exceptions or claims as Tenant may properly make and describe therein) the following: (i) this Lease is unmodified, and is valid and in full force and effect, (ii) the Commencement Date, Expiration
Date, and rentable area of the Premises, (iii) no Rent has been paid more than one month in advance, and the annual and monthly Base Rent, Tenant’s Share of Taxes, Insurance and Expenses, and current payments thereof, and Security Deposit,
(iv) Tenant is in possession of the Premises, and paying Rent on a current basis with no offsets, defenses or claims, (v) there are no uncured defaults on the part of Landlord or Tenant, and no events or conditions which, with the giving
of notice or lapse of time or both, would constitute a default by Tenant or Landlord, (vi) Tenant has no options to purchase the Property or terminate this Lease, nor any expansion, reduction or extension rights, (vii) Landlord has
satisfied any obligations to perform or reimburse Tenant for any leasehold improvements, and Tenant is not entitled to any Rent abatement period after the date of the certificate, and (viii) certifying such other matters, and including such
current financial statements, as Landlord may reasonably request, or as may be requested by Landlord’s current or prospective Lenders, insurance carriers, auditors, and prospective purchasers (and including a comparable certification statement
from any subtenant respecting its sublease). Any such statement may be relied upon by any such parties. If Tenant shall fail to execute and return such statement within the time required/herein, Tenant shall be in Default, and shall be deemed to
have agreed with the matters set forth therein (without limiting Landlord’s other remedies). 
 ARTICLE 20: RIGHTS
RESERVED BY LANDLORD 
 Except to the extent expressly limited herein, Landlord reserves full rights to control the Property
(which rights may be exercised without subjecting Landlord to claims for constructive eviction, abatement of Rent, damages or other claims of any kind), including more particularly, but without limitation, the following rights: 
 A. General Matters. To: (i) change the name or street address of the Property or designation of the Premises (provided Landlord
gives Tenant at least thirty (30) days advance notice, and reimburses Tenant for reasonable costs for reasonable supplies of Tenant’s stationery and business cards that can no longer be used as a result of such change upon reasonable
evidence thereof), (ii) install and maintain signs on and about the Property, and grant any other Person the right to do so, (iii) retain at all times, and use in appropriate instances, keys to all doors within and into the Premises,
(iv) grant to any Person the right to conduct any business or render any service at the Property, whether or not the same are similar to the use permitted Tenant by this Lease, (v) have access for Landlord and other tenants of the Property
to any mail chutes located on the Premises according to the rules of the United States Postal Service (and to install or remove such chutes), and (vi) in case of fire, invasion, insurrection, riot, civil disorder, public excitement or other
dangerous condition, or threat thereof: (a) limit or prevent access to the Property, (b) shut down elevator service, (c) activate elevator emergency controls, and (d) otherwise take such action or preventative measures deemed
necessary by Landlord for the safety of tenants of the Property or the protection of the Property and other property located thereon or therein (but this provision shall impose no duty on Landlord to take such actions, and no liability for actions
taken in good faith). 
 B. Access To Premises. Subject to the following provisions, to enter the Premises in order to:
(i) inspect, (ii) supply cleaning service or other services to be provided Tenant hereunder, (iii) show the Premises to current and prospective Lenders, insurers, purchasers, governmental authorities, and their representatives, and
during the last nine (9) months of Tenant’s occupancy, show the Premises to prospective tenants and leasing brokers, and (iv) decorate, remodel or alter the Premises if Tenant abandons the Premises at any time or vacates the same
during the last 120 days of the Term (without thereby terminating this Lease), and (v) perform any work or take any other actions under Paragraph C below, or exercise other rights of Landlord under this Lease or applicable Laws. If Tenant
requests that any such access occur before or after normal building hours, and Landlord schedules the work accordingly, Tenant shall pay all overtime and other additional costs in connection therewith. In 
  

					
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connection with any such access to the Premises, except in emergencies or for cleaning or other routine services to be provided to Tenant under this Lease, Landlord shall: (a) provide
reasonable advance written or oral notice to Tenant’s on-site manager or other appropriate person, (b) be accompanied at all times by a representative of Tenant (if mutual scheduling thereof is reasonably feasible), and (c) take
reasonable steps to minimize any disruption to Tenant’s business. 
 C. Changes To The Property. Subject to the last
sentence of this Paragraph, to; (i) paint and decorate, (ii) perform repairs or maintenance, and (iii) make replacements, restorations, renovations, alterations, additions and improvements, structural or otherwise (including freon
retrofit work), in and to the Property or any part thereof, including any adjacent building, structure, facility, land, street or alley, or change the uses thereof (other than Tenant’s permitted use under this Lease), including changes,
reductions or additions of corridors, entrances, doors, lobbies, parking facilities and other areas, structural support columns and shear walls, elevators, stairs, escalators, mezzanines, solar tint windows or film, kiosks, planters, sculptures,
displays, and other amenities and features therein, and changes relating to the connection with or entrance into or use of the Property or any other adjoining or adjacent building or buildings, now existing or hereafter constructed. In connection
with such matters, Landlord may erect scaffolding, barricades and other structures, open ceilings, close entry ways, restrooms, elevators, stairways, corridors, parking and other areas and facilities, and take such other actions as Landlord deems
appropriate. Notwithstanding anything to the contrary herein, Landlord shall: (a) maintain reasonable access to the Premises, (b) not materially restrict or impair Tenant’s use of the Premises or any rights expressly granted to Tenant
under this Lease, and (c) in connection with entering the Premises, comply with the last sentence of Paragraph B above (including subclauses (a) and (b) thereof). 
 D. New Premises. Intentionally omitted. 
 ARTICLE 21: LANDLORD’S RIGHT TO CURE 
 If Landlord shall fail to
perform any obligation under this Lease required to be performed by Landlord, Landlord shall not be deemed to be in default hereunder nor subject to any claims for damages of any kind, unless such failure shall have continued for a period of thirty
(30) days (in non-emergency situations) or ten (10) days (in emergency situations), as applicable, after notice thereof by Tenant (provided, if the nature of Landlord’s failure is such that more time is reasonably required in order to
cure, Landlord shall not be in default if Landlord commences to cure within such applicable period and thereafter diligently seeks to cure such failure to completion). If Landlord shall default and fail to cure as provided herein, Tenant shall have
such rights and remedies as may be available to Tenant under applicable Laws, subject to the other provisions of this Lease; provided, Tenant shall have no right of self-help to perform repairs or any other obligation of Landlord, and shall have no
right to withhold, set-off or abate Rent, or terminate this Lease, except as may be expressly provided in this Lease. 
 ARTICLE 22: INDEMNIFICATION 
 Subject to the provisions of Articles 10 and 11, Tenant shall defend, indemnify
and hold Landlord harmless from and against any and all claims, demands, losses, penalties, fines, fees, charges, assessments, liabilities, damages, judgments, orders, decrees, actions, administrative or other proceedings, costs and expenses
(including reasonable attorneys’ and expert witness fees, and court costs), arising or alleged to arise from: (i) any violation or breach of this Lease or applicable Law by any Tenant Parties (as defined below), (ii) damage, loss or
injury to persons, property or business directly or indirectly arising out of any Tenant Party’s use of the Premises or Property, or out of any other act or omission of any Tenant Parties, and (iii) any other damage, loss or injury to
persons, property or business occurring in, about or from the Premises, except to the extent that such other damage, loss or injury to persons, property or business is caused by the negligence or intentional misconduct of Landlord or its agents or
employees. For purposes of this provision, “Tenant Parties” shall, mean Tenant, any other occupant of the Premises and any of their respective agents, employees, invitees, Transferees and contractors. Subject to Articles 10 and 11 and the
other provisions of this Lease, and excluding matters

  

					
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covered by Tenant’s foregoing indemnity obligations. Landlord shall defend, indemnify and hold harmless Tenant from and against claims, demands, losses, penalties, fines, fees, charges,
assessments, liabilities, damages, judgments, orders, decrees, actions, administrative or other proceedings, costs and expenses (including reasonable attorneys’ and expert witness fees, and court costs) arising in the common areas of the Properly from or relating to any loss
of life, damage or injury to persons, property or business to the extent caused by any violation or breach of this Lease or any other negligence, intentional misconduct, or any other act or omission of Landlord or Landlord’s agents or
employees. 
 ARTICLE 23: RETURN OF POSSESSION 
 A. General Provisions. At the expiration or earlier termination of this Lease or Tenant’s right of possession, Tenant shall
vacate and surrender possession of the entire Premises in the condition required under Article 8 and the Rules, ordinary wear and tear and casualty damage excepted, shall surrender all keys and key cards, and any parking transmitters, stickers or
cards to Landlord, and shall remove all personal property and trade fixtures that may be readily removed without damage to the Premises or Property, subject to the following provisions. 
 B. Landlord’s Property. Alt improvements, fixtures and other items, including ceiling light fixtures, HVAC equipment, plumbing
fixtures, hot water heaters, fire suppression and sprinkler systems, Lines under Article 28, built-in shelves and cabinets, interior partitioning, interior stairs, wall coverings, carpeting and other flooring, blinds, drapes and window treatments,
in or serving the Premises, whether installed by Tenant or Landlord, and any other items installed or provided by Landlord or at Landlord’s expense (including any modular furniture provided or paid for by Landlord), shall be Landlord’s
property and shall remain upon the Premises, all without compensation, allowance or credit to Tenant, unless Landlord elects otherwise as provided in Paragraph C below. 
 C. Removal of Items by Tenant. Notwithstanding the foregoing to the contrary, if prior to expiration or earlier termination of this Lease or within thirty (30) days thereafter Landlord so
directs by notice, Tenant shall promptly remove such items described in Paragraph B above as are designated in such notice and restore the Premises to the condition prior to the installation of such items in a good and workmanlike manner; provided,
Landlord shall not require removal of any such items that: (I) already existed in the Premises before this Lease and Tenant’s occupancy of the Premises, or (ii) involve customary leasehold improvements that are installed by or for
Tenant pursuant to the provisions of this Lease (including any Exhibit hereto) except to the extent that Landlord reserves the right to require such removal in connection with Landlord’s approval of the plans therefor, or (iii) involve the
restoration of lab space to office space. 
 D. Tenant’s Failure to Remove Items. If Tenant shall fail to remove any
items from the Premises as required hereunder, Landlord may do so and Tenant shall pay Landlord’s charges therefor upon demand. All such property removed from the Premises by Landlord pursuant to any provisions of this Lease or any Law may be
handled or stored by Landlord at Tenant’s expense, and Landlord shall in no event be responsible for the value, preservation or safekeeping thereof. All such property not removed from the Premises or retaken from storage by Tenant within thirty
(30) days after expiration or earlier termination of this Lease or Tenant’s right to possession shall, at Landlord’s option, be conclusively deemed to have been conveyed by Tenant to Landlord as if by bill of sale without payment by
Landlord. Landlord shall have a lien against such property for the costs incurred in removing and storing the same. 
 ARTICLE
24: HOLDING OVER 
 Unless Landlord expressly agrees otherwise in writing, Tenant shall pay Landlord 150% for the first
thirty (30) days, and thereafter 200%, of the amount of Rent then applicable prorated on a per diem basis for each day that Tenant shall fail to vacate or surrender possession of the Premises or any part thereof after expiration or earlier
termination of this Lease as required under Article 23, together with all damages (direct and consequential) sustained by Landlord on account thereof; provided, Tenant shall not

  

					
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be liable for consequential damages unless Tenant holds over for more than thirty (30) days. Tenant shall pay such amount of Rent monthly in advance (subject to refund of any partial month
occupancy prorated on a per diem basis), and such other amounts on demand. The foregoing provisions, and Landlord’s acceptance of any such amounts, shall not serve as permission for Tenant to hold-over, nor serve to extend the Term (although
Tenant shall remain a tenant-at-sufferance bound to comply with ail other ; provisions of this Lease until Tenant properly vacates the Premises, including Article 23), and Landlord shall have such other remedies to recover possession of the Premises
as may be available to Landlord under applicable Laws. 
 ARTICLE 25: NOTICES 
 Except as expressly provided to the contrary in this Lease, every notice or other communication to be given by either party to the other
with respect hereto or to the Premises or Property, shall be in writing and shall not be effective unless served personally or by national air courier service, or United States certified mail, return receipt requested, postage prepaid, to the
parties at the addresses set forth in Article 1, or such other address or addresses as Tenant or Landlord may from time to time designate by notice given as above provided. Every notice or other communication hereunder shall be deemed to have been
given as of the third business day following the date of such mailing (or as of any earlier date evidenced by a receipt from such national air courier service or the United States Postal Service) or immediately if personally delivered. Notices not
sent in accordance with the foregoing shall be effective when received by the parties at the addresses required herein. 
 ARTICLE 26: REAL ESTATE BROKERS 
 Landlord and Tenant hereby mutually: (i) represent and warrant to each
other that they have dealt only with the broker, if any, designated in Article 1 (whose commission, if any, shall be paid pursuant to separate written agreement by Landlord) as broker, agent or finder in connection with this Lease, and
(ii) agree to defend, indemnify and hold each other harmless from and against any and all claims, demands, losses, liabilities, damages, judgments, costs and expenses (including reasonable attorneys’ and expert witness fees, and court
costs), arising or alleged to arise from any breach of their respective foregoing representation and warranty under this Article. 
 ARTICLE 27: NO WAIVER 
 No provision of this Lease will be deemed waived by either party unless expressly
waived in writing and signed by the waiving party. No waiver shall be implied by delay or any other act or omission of either party. No waiver by either party of any provision of this Lease shall be deemed a waiver of such provision with respect to
any subsequent matter relating to such provision, and Landlord’s consent or approval respecting any action by Tenant shall not constitute a waiver of the requirement for obtaining Landlord’s consent or approval respecting any subsequent
action. Acceptance of Rent by Landlord directly or through any agent or lock-box arrangement shall not constitute a waiver of any breach by Tenant of any term or provision of this Lease (and Landlord reserves the right to return or refund any
untimely payments if necessary to preserve Landlord’s remedies). No acceptance of a lesser amount of Rent shall be deemed a waiver of Landlord’s right to receive the full amount due, nor shall any endorsement or statement on any check or
payment or any letter accompanying such check or payment be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the full amount due. The acceptance of Rent or of the
performance of any other term or provision from, or providing directory listings or services for, any Person other than Tenant shall not constitute a waiver of Landlord’s right to approve any Transfer. No delivery to, or acceptance by, Landlord
or its agents or employees of keys, nor any other act or omission of Tenant or Landlord or their agents or employees, shall be deemed a surrender, or acceptance of a surrender, of the Premises or a termination of this Lease, unless stated expressly
in writing by Landlord. 
  

					
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 ARTICLE 28: TELECOMMUNICATION LINES 
 A. Telecommunication Lines. Subject to Landlord’s continuing right of reasonable supervision and reasonable approval, and the
other provisions hereof, Tenant may: (i) install telecommunication lines (“Lines”) connecting the Premises to any Property terminal block already serving or available to serve the Premises, or (ii) use such Lines as may currently
exist and already connect the Premises to such terminal block. Such terminal block may comprise, or be connected through riser or other Lines with, a main distribution frame (“MDF”) for the Property. Landlord disclaims any representations,
warranties or understandings concerning the capacity, design or suitability of any such terminal or MDF, Property riser Lines, or related equipment. Landlord may arrange for an independent contractor to review Tenant’s requests for approval
hereunder, monitor or supervise Tenant’s installation, connection and disconnection of Lines, and provide other such services, or Landlord may provide the same, and Tenant shall pay Landlord’s reasonable charges therefor as provided in
Article 9. 
 B. Installation. Tenant may install and use Tenant’s Lines and make connections and disconnections at
the terminal blocks as described above, provided Tenant shall; (i) obtain Landlord’s prior written reasonable approval of all aspects thereof, (ii) use an experienced and qualified contractor reasonably designated or approved in
writing in advance by Landlord (whom Landlord may require to enter an access and indemnity agreement on Landlord’s then-standard form of agreement’ therefor), (iii) comply with such reasonable inside wire standards as Landlord may
adopt from time to time, and ail other provisions of this Lease, including Article 9 respecting Work, and the Rules respecting access to the wire closets, (iv) not install Lines in the same sleeve, chaseway or other enclosure in close proximity
with electrical wire, and not install PVC-coated Lines under any circumstances, (v) thoroughly test any riser Lines to which Tenant intends to connect any Lines to ensure that such riser Lines are available and are not then connected to or used
for telephone, data transmission or any other purpose by any other party (whether or not Landlord has previously approved such connections), and not connect to any such unavailable or connected riser Lines, and (vi) not connect any equipment to
the Lines which may create an electromagnetic field exceeding the normal insulation ratings of ordinary twisted pair riser cable or cause radiation higher than normal background radiation, unless the Lines therefor (including riser Lines) are
appropriately insulated to prevent such excessive electromagnetic fields or radiation (and such insulation shall not be provided by the use of additional unused twisted pair Lines). As a condition to permitting installation of new Lines, Landlord
may require that Tenant remove any existing Lines located in or serving the Premises previously installed or utilized by Tenant. 
 C. Limitation of Liability. Except to the extent due to Landlord’s intentional misconduct or grossly negligent acts, Landlord shall have no liability for damages arising, and Landlord does not warrant that the Tenant’s use
of the Lines will be free, from the following (collectively called “Line Problems”): (i) any eavesdropping, wire-tapping or theft of long distance access codes by unauthorized parties, (ii) any failure of the Lines to satisfy
Tenant’s requirements, or (iii) any capacitance, attenuation, cross-talk or other problems with the Lines, any misdesignation of the Lines in the MDF room or wire closets, or any shortages, failures, variations, interruptions,
disconnections, loss or damage caused by or in connection with the installation, maintenance, replacement, use or removal of any other Lines or equipment at the Property by or for other tenants at the Property, by any failure of the environmental
conditions at or the power supply for the Property to conform to any requirements of the Lines or any other problems associated with any Lines or by any other cause. Under no circumstances shall any Line Problems be deemed an actual or constructive
eviction of Tenant, render Landlord liable to Tenant for abatement of any Rent or other charges under the Lease, or relieve Tenant from performance of Tenant’s obligations under the Lease. Landlord in no event shall be liable for damages by
reason of loss of profits, business interruption or other consequential damage arising from any Line Problems. 
 ARTICLE 29:
HAZARDOUS MATERIALS 
 A. Hazardous Materials Generally Prohibited. Tenant shall not transport, use, store, maintain,
generate, manufacture, handle, dispose, release, discharge, spill or leak any “Hazardous Material”

  

					
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(as defined in Article 30), or permit Tenants employees, agents, contractors, or other occupants of the Premises to engage in such activities on or about the Property. However, the foregoing
provisions shall not prohibit the transportation to and from, and use, storage, maintenance and handling within, the Premises of substances customarily and lawfully used as an incidental and minor part of the business or activity expressly permitted
to be undertaken in the Premises under this Lease, provided: (i) such substances shall be properly labeled, contained, used and stored only in small quantities reasonably necessary for such permitted use of the Premises and the ordinary course
of Tenant’s business therein, strictly in accordance with applicable Laws, highest prevailing standards, and the manufacturers’ instructions therefor, and as Landlord shall reasonably require (but no warning notices or symbols shall be
placed, or required to be placed, on or near any door to or within the Premises or Property), (ii) Tenant shall provide Landlord with advance notice and current Material Safety Data Sheets (“MSDSs”) therefor, (iii) such
substances shall not be disposed of, released, discharged or permitted to spill or leak in or about the Premises or the Property (and under no circumstances shall any Hazardous Material be disposed of within the drains or plumbing facilities in or
serving the Premises or Property or in any other public or private drain or sewer, regardless of quantity or concentration), (iv) if any applicable Law or Landlord’s trash removal contractor requires that any such substances be disposed of
separately from ordinary trash, Tenant shall make arrangements at Tenant’s expense for such disposal in approved containers directly with a qualified and licensed disposal company at a lawful disposal site, (v) any remaining such
substances shall be completely, properly and lawfully removed from the Property upon expiration or earlier termination of this Lease, and (vi) for purposes of removal and disposal of any such substances, Tenant shall be named as the owner,
operator and generator, shall obtain a waste generator identification number, and shall execute all permit applications, manifests, waste characterization documents and any other required forms. 
 B. Notifications. Tenant shall immediately notify Landlord of: (i) any inspection, enforcement, cleanup or other regulatory
action taken or threatened by any regulatory authority with respect to any Hazardous Material on or from the Premises or the migration thereof from or to other property, (ii) any demands or claims made or threatened by any party relating to any
loss or injury claimed to have resulted from any Hazardous Material on or from the Premises, (iii) any release, discharge, spill, leak, migration, disposal or transportation of any Hazardous Material on or from the Premises in violation of this
Article, and any damage, loss or injury to persons, property or business resulting or claimed to have resulted therefrom, and (iv) any matters where Tenant is required by Law to give a notice to any regulatory authority respecting any Hazardous
Material on or from the Premises. Landlord shall have the right (but not the obligation) to notify regulatory authorities concerning actual and claimed violations of this Article, and to join and participate, as a party, in any legal proceedings or
actions affecting the Premises and concerning Hazardous Materials or otherwise initiated under any environmental, health or safety Law. 
 C. Hazardous Materials Questionnaire. At such times as Landlord may reasonably request, Tenant shall accurately and completely fill out, sign (and certify to be accurate and complete) and return
Landlord’s then current form of Tenant Hazardous Materials Questionnaire and Disclosure Statement (“Hazardous Materials Questionnaire”) which shall: (i) identify, describe and list quantities of any Hazardous Materials that have
been transported to or from, used, stored, generated, handled, maintained, disposed, released, discharged, spilled, leaked or migrated in or from the Premises since the Commencement Date or the last such Hazardous Materials Questionnaire, and any
such activity that is anticipated during the next twelve (12) months, (ii) provide information concerning past, present and anticipated disposal practices, storage tanks, process tanks, dip tanks, waste management practices, waste water
discharge/treatment practices, air discharges, regulatory actions, and such other information as Landlord requires, and (iii) include copies of any material safety data sheets (“MSDS”) issued by the manufacturer, distributor or
importer for any such Hazardous Materials. Landlord shall generally not require such Environmental Questionnaires more than once per year, except if required by Law or a Lender, or in connection with a proposed sale or financing of the Property, or
if based on Tenant’s answers to any prior Environmental Questionnaire or an inspection of the Premises, or if Landlord determines that more frequent Environmental Questionnaires are reasonably required. 
 D. Hazardous Materials Records; Inspections, Tests and Studies. Tenant shall immediately upon written request from time to time
provide Landlord with copies of all permits, approvals, memos, reports, correspondence, complaints, demands, claims, subpoenas, requests, feasibility and impact

  

					
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studies, storage and management plans, business plans, remediation and cleanup plans, closure plans, documentation evidencing that a clean-up or other action required hereunder has been properly
and lawfully completed, and all papers of any kind filed with or by any regulatory authority and any other books, records or items pertaining to Hazardous Materials that are subject to the provisions of this Article (collectively referred to herein
as “Tenant’s Hazardous Materials Records”). Landlord reserves the right to conduct, and to request that regulatory authorities conduct, from time to time, detailed inspections, tests and studies at or respecting the Premises, and of
Tenants operations therein including, without limitation, air, soil, water and the contents of any cans, bottles, jars, drums, barrels or other containers, and Tenant’s Hazardous Materials Records, respecting Tenant’s compliance with this
Article. In connection therewith, Tenant shall fully cooperate and shall instruct Tenant’s officers and employees to answer all questions truthfully and completely. Such inspections, tests and studies may be made with or without prior notice.
If Landlord or any Lender or regulatory authority arranges for any inspections, tests or studies showing this Article has been violated, or otherwise in connection with any request by Tenant for permission to engage in any activity or to waive any
requirement involving Hazardous Materials, Tenant shall pay for the cost of such inspections, tests and studies and an amount equal to fifteen percent (15%) of such cost to cover Landlord’s overhead. 
 E. Clean Up Responsibilities. Subject to the last sentence of this Article 29. E, if any Hazardous Material is released, discharged
or disposed of, or permitted to spill, leak or migrate, in violation of the foregoing provisions, Tenant shall immediately, properly and in compliance with applicable Laws, clean up and remove the Hazardous Material from the Premises, Property and
any other affected property and clean or replace any affected personal properly (whether or not owned by Landlord), at Tenant’s expense (without limiting Landlord’s other remedies therefor). Such clean up and removal work shall be
considered “Work” under Article 9 and subject to the provisions thereof including, without limitation, Landlord’s prior written approval (except in emergencies), and any testing, investigation, feasibility and impact studies, and the
preparation and implementation of any remedial action plan required by any court or regulatory authority having jurisdiction or reasonably required by Landlord. In connection therewith, Tenant shall provide documentation evidencing that all Tenant
Remedial Work or other action required hereunder has been properly and lawfully completed (including a certificate addressed to Landlord from a environmental consultant reasonably acceptable to Landlord, in such detail and form as Landlord may
reasonably require). If any Hazardous Material is released, discharged, disposed of, or permitted to spill, leak or migrate on or about the Property and is not caused by Tenant or other occupants of the Premises, or their agents, employees,
Transferees, or contractors, such release, discharge, disposal, spill, teak or migration shall be deemed casualty damage under Article 11 to the extent that the Premises and Tenant’s use thereof is affected thereby; in such case, Landlord and
Tenant shall have the obligations and rights respecting such casualty damage provided under such Article. If any Hazardous Material contamination is discovered on or about the Property before Tenant begins occupying or performing work at the
Premises, there shall be a rebuttable presumption that Tenant is not responsible; if any Hazardous Material contamination is discovered on or about the Property after Tenant begins occupying or performing work at the Premises, and the contamination
is located in the Premises or areas of the Property exclusively serving the Premises, there shall be a rebuttable presumption that Tenant is responsible (including Landlord’s obligations to restore under Article 11 .A, and Tenant’s rights
to abate Rent under Article 11.B). 
 F. Storage Tanks and Ponds. Tenant shall not install or use storage tanks on or
about the Premises (whether under, on or above ground) without Landlord’s prior written consent, which consent may be withheld in Landlord’s sole discretion. Tenant shall not engage in or permit ponding or surface storage or treatment of
Hazardous Materials under any circumstances. If Landlord permits Tenant to install or use a storage tank, Tenant shall comply with all applicable Laws in connection therewith, and at Landlord’s request shall properly and lawfully remove such
tank upon expiration or earlier termination of this Lease (or sooner if such tank is found to leak or removal is required by applicable Laws) in accordance with removal procedures approved by Landlord in advance in writing. 
 G. Fees, Taxes, Fines and Remedies. Tenant shall pay, prior to delinquency, any and all fees, taxes (including excise taxes),
penalties and fines arising from or based on Tenant’s activities involving Hazardous Material on or about the Premises or Property, and shall not allow such obligations to become a lien or charge against the Property or Landlord. If Tenant
violates any provision of this Article with respect to any Hazardous Materials, Landlord may: (i) require that Tenant immediately remove all Hazardous Materials from the Premises and discontinue using, storing and handling Hazardous Materials
in the Premises, and/or (ii) pursue such other remedies as may be available under this Lease or applicable Law. 
  

					
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 ARTICLE 30: DEFINITIONS 
 (A) “Building” shall mean the structure (or the portion thereof owned by Landlord) identified in Article 1. 
 (B) “Default Rate” shall mean one and one half percent (1.5%) per month, or the highest rate permitted by applicable
Law, whichever shall be less. 
 (C) “Expenses” shall mean all expenses, costs and amounts (other than Taxes,
unless Landlord elects to bill Taxes as part of Expenses) of every kind and nature relating to the ownership, management, repair, maintenance, replacement, insurance and operation of the Property, including, without limitation (except as expressly
set forth herein): (i) utilities, including electricity, gas, steam, oil or other fuel, water and sewer services (but excluding any such costs for the Premises paid directly by Tenant pursuant to Article 6), (ii) complying with Laws,
subject to the exclusions below, (iii) Insurance (but only if Landlord elects to bill Insurance as part of Expenses and not separately), (iv) supplies, materials, tools and equipment, including rental, installment purchase and financing
agreements therefor, (v) accounting, security, janitorial, property management and other services (but excluding janitorial costs for the Premises paid directly by Tenant pursuant to Article 6), (vi) compensation and benefits for personnel
providing services at or below the level of senior property manager (but if personnel handle other properties or functions, the foregoing expenses shall be allocated appropriately between the Property and such other properties or functions),
(vii) payments under any reciprocal easement, declaration or other agreement for sharing common area costs or other matters in any development or complex in which the Property is located, (viii) sales or other taxes on supplies or services
for the Property, (ix) operating and maintaining a property management office, including the fair rental value, appropriately allocated between the Property and any other property served by such office, and (x) operation, maintenance,
repair, installation, replacement, painting, decorating and cleaning of the Property and off-site items that benefit the Property, including signs, traffic signals, drainage and irrigation systems, sidewalks, driveways, parking facilities, loading
and service areas, landscaping, common area fixtures, trash compactors, doors, windows, roofs, Systems and Equipment, and any other features of and services for the Property. The foregoing provision is for definitional purposes and shall not impose
any obligation upon Landlord to incur such expenses, nor limit other Expenses that Landlord may incur for the Property. Landlord may retain independent contractors (or affiliated contractors at market rates) to provide any services or perform any
work, in which case the costs thereof shall be deemed Expenses. Expenses shall, however, exclude: 
 (1) the
following items: (a) interest and amortization on Mortgages, and other debt costs or ground lease payments, if any, except as provided herein, (b) depreciation of buildings and other improvements (except permitted amortization of certain
capital expenditures as provided below), (c) legal fees in connection with leasing, tenant disputes or enforcement of leases, (d) real estate brokers’ commissions or marketing costs, (e) improvements or alterations to tenant
spaces, (f) the cost of providing any service directly to, and paid directly by, any tenant, (g) costs of any items to the extent Landlord receives reimbursement from insurance proceeds or from a warranty or other such third party (such
proceeds to be deducted from Expenses in the year in which received); (h) the cost of work in connection with a Condemnation proceeding, (i) costs incurred in removing or abating asbestos, (j) costs arising from the existence of
hazardous materials and hazardous substances in or about the Property in violation of any legal requirements, (k) accounting fees and auditing expenses (at the ownership level, as opposed to normal property management accounting and auditing
costs), (l) costs in connection with arbitration proceedings and litigation with tenants, (m) items included in Taxes, and (n) amounts required to purchase any sculptures, paintings and other works of fine art displayed within or
about the Property; and 
  

					
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 (2) capital expenditures, except those: (a) made primarily to reduce
Expenses or increases therein (provided that the amount passed through shall not exceed the amount of the savings in any year), or to comply with Laws or insurance requirements (excluding capital expenditures to cure violations of Laws or insurance
requirements that existed prior to the date of this Lease), or (b) for replacements (as opposed to additions or new improvements) of roofs and parking areas, and other nonstructural items located in the common areas of the Property required to
keep such areas in good condition; provided, any such permitted capital expenditure shall be amortized (with interest at the prevailing loan rate available to Landlord when the cost was incurred) over: (x) the period during which the reasonably
estimated savings in Expenses equals the expenditure, if applicable, or (y) the useful life of the item as reasonably determined by Landlord. 
 (D) “Hazardous Material” shall include, but not be limited to: (i) any flammable, explosive, toxic, radioactive, biological, corrosive or otherwise hazardous chemical, substance,
liquid, gas, device, form of energy, material or waste or component thereof, (ii) petroleum-based products, diesel fuel, paints, solvents, lead, radioactive materials, cyanide, biohazards, infectious or medical waste and “sharps”,
printing inks, acids, DDT, pesticides, ammonia compounds, and any other items which now or subsequently are found to have an adverse effect on the environment or the health and safety of persons or animals or the presence of which require
investigation or remediation under any Law or governmental policy, and (iii) any item defined as a “hazardous substance”, “hazardous material”, “hazardous waste”, “regulated substance” or “toxic
substance” under the Comprehensive Environmental Response, Compensation and Liability Act of 1980, as amended, 42 U.S.C. §9601, et seq., Hazardous Materials Transportation Act, 49 U.$.C. §1801, et seq., Resource Conservation and
Recovery Act of 1976, 42 U.S.C. §6901 et seq., Clean Water Act, 33 U.S.C. §1251, et seq., Safe Drinking Water Act, 14 U.S.C. §300f, et seq., Toxic Substances Control Act, 15 U.S.C. §2601, et seq., Atomic Energy Act of 1954, 42
U.S.C. §2014 et seq., and any similar federal, state or local Laws, and all regulations, guidelines, directives and other requirements thereunder, all as may be amended or supplemented from time to time. 
 (E) “Insurance” shall mean costs of insurance that Landlord maintains for the Property, which may include, but shall not be
limited to, commercial general liability, casualty damage, flood, earthquake, boiler and machinery, rent loss, workers’ compensation and employers’ liability, builders’ risk, automobile, and other coverages, in such amounts and with
such deductibles and other features as Landlord deems commercially appropriate, and including a reasonable allocation of such costs under any blanket policies and self-retention funds. 
 (F) “Landlord” shall mean only the landlord from time to time, except that for purposes of any provisions defending,
indemnifying and holding Landlord harmless hereunder, “Landlord” shall include past, present and future landlords and their respective partners, beneficiaries, trustees, officers, directors, employees, shareholders, principals, agents,
affiliates, successors and assigns. 
 (G) “Law” or “Laws” shall mean all federal, state,
county and local governmental and municipal laws, statutes, ordinances, rules, regulations, codes, decrees, orders and other such requirements, applicable equitable remedies and decisions by courts in cases where such decisions are considered
binding precedents in the State in which the Property is located, and decisions of federal courts applying the Laws of such State, at the time in question. This Lease shall be interpreted and governed by the Laws of the State in which the Property
is located. 
 (H) “Lender” shall mean the holder of any Mortgage at the time in question, and where such
Mortgage is a ground lease, such term shall refer to the ground lessor (and the term “ground lease” although not capitalized is intended throughout this Lease to include any superior or master lease). 
 (I) “Mortgage” shall mean all mortgages, deeds of trust, ground leases and other such encumbrances now or hereafter placed
upon the Property or Building, or any part thereof, and all renewals, modifications, consolidations, replacements or extensions thereof, and all indebtedness now or hereafter secured thereby and all interest thereon. 
 (J) “Person” shall mean an individual, trust, partnership, limited liability company, joint venture, association,
corporation and any other entity. 
  

					
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 (K) “Premises” shall mean the area within the Building identified in
Article 1 and Exhibit A. Landlord reserves the right to use (or grant other parties the right to use) and Tenant shall have no right, title or interest in: (i) the roof of the Building, (ii) exterior portions of the Premises
(including, without limitation, demising walls and outer walls of the Building), (iii) air rights above the Premises and rights to the land and improvements below the floor level of the Premises, and (iv) areas within the Premises
necessary for utilities, services, safety and operation of the Building or Property, including systems and equipment, fire stairways, and space between any suspended ceiling of the Premises and the slab of the floor or roof of the Property
thereabove. If the Premises does not contain a suspended ceiling, the Premises shall extend vertically to the height where, in Landlord’s reasonable opinion, a suspended ceiling would otherwise exist, and Landlord reserves the right to install
a suspended ceiling and/or use the area thereabove. 
 (L) “Property” shall mean the Building, and any common
or public areas or facilities, easements, corridors, lobbies, sidewalks, loading areas, driveways, landscaped areas, skywalks, parking rights, garages and lots, and any and all other rights, structures or facilities operated or maintained in
connection with or for the benefit of the Building, and all parcels or tracts of land on which all or any portion of the foregoing items are located, and any fixtures, machinery, apparatus, Systems and Equipment, furniture and other personal
property located thereon or therein and used in connection with the operation thereof. Landlord reserves the right to add land, buildings, easements or other interests to, or sell or eliminate the same from, the Property, and grant interests and
rights in the Property to other parties. If the Building shall now or hereafter be part of a development or complex of buildings or structures collectively owned by Landlord or its affiliates, the Property shall, at Landlord’s option, also be
deemed to include such other of those buildings or structures as Landlord shall from time to time designate, and shall initially include such buildings and structures (and related facilities and parcels on which the same are located) as Landlord
shall have incorporated by reference to the total rentable area of the Property in Article 1. 
 (M) “Rent”
shall have the meaning specified therefor in Article 3. 
 (N) “Systems and Equipment” shall mean any plant,
machinery, transformers, duct work, cable, wires, and other equipment, facilities, and systems designed to supply light, heat, ventilation, air conditioning and humidity or any other services or utilities, or comprising or serving as any component
or portion of the electrical, gas, steam, plumbing, sprinkler, communications, alarm, security, or fire/life/safety systems or equipment, or any elevators, escalators or other mechanical, electrical, electronic, computer or other systems or
equipment for the Property, except to the extent that any of the same serves particular tenants exclusively (and “systems and equipment” without capitalization shall refer to such of the foregoing items serving particular tenants
exclusively). 
 (O) “Taxes” shall mean all amounts (unless required by Landlord to be paid under Article 14 or
as Expenses) for federal, state, county, or local governmental, special district, improvement district, municipal or other political subdivision taxes, fees, levies, assessments, charges or other impositions of every kind and nature in connection
with the ownership, leasing and operation of the Property, whether foreseen or unforeseen, general, special, ordinary or extraordinary (including real estate and ad valorem taxes, general and special assessments, transit taxes, water and sewer
rents, license and business license fees, use or occupancy taxes, gross receipts or sales taxes, taxes on personal property and property management services, and taxes or charges for fire protection, streets, sidewalks, road maintenance, refuse or
other services). If the method of taxation of real estate prevailing at the time of execution hereof shall be, or has been, altered so as to cause the whole or any part of the Taxes now, hereafter or heretofore levied, assessed or imposed on real
estate to be levied, assessed or imposed on Landlord, wholly or partially, as a capital stock levy or otherwise, or on or measured by the rents, income or gross receipts received therefrom, then such new or altered taxes shall be included within the
term “Taxes,” except that the same shall not include any portion of such tax attributable to other income of Landlord not relating to the Property. Tenant shall pay increased Taxes whether Taxes are increased as a result of increases in
the assessment or valuation of the Property (whether based on a sale, change in ownership or refinancing of the Property or otherwise), increases in tax rates, reduction or elimination of any rollbacks or other deductions available under current
law, scheduled reductions of any tax abatement, as a result of the elimination, invalidity or withdrawal of any tax abatement, or for any other

  

					
		  	30	  	

 
cause whatsoever. Notwithstanding the foregoing, there shall be excluded from Taxes all excess profits taxes, franchise taxes, gift taxes, capital stock taxes, inheritance and succession taxes,
estate taxes, federal and state income taxes, and other taxes to the extent applicable to Landlord’s general or net income (as opposed to rents, receipts or income attributable to operations at the Property). 
 (P) “Tenant” shall be applicable to one or more Persons as the case may be, the singular shall include the plural, and if
there be more than one Tenant, the obligations thereof shall be joint and several. When used in the lower case, “tenant” shall mean any other tenant or occupant of the Property. 
 (Q) “Tenant’s Share” of Taxes, Insurance and Expenses shall be the percentage set forth in Article 1, but if the
rentable area of the Premises changes due to the addition or subtraction of space under this Lease or by amendment, Landlord shall reasonably adjust Tenant’s Share to be based on the rentable area of the Premises divided by the rentable area of
the Property, subject to further adjustment hereunder and under Article 3. If the Property shall now or hereafter be part of or shall include a development or complex of two or more buildings or structures collectively owned by Landlord or its
affiliates, Landlord may allocate Taxes, Insurance and Expenses (or components thereof) within such complex or development, and between such buildings and structures and the parcels on which they are located, in accordance with sound accounting and
management practices. In the alternative, Landlord may determine Tenant’s Share of Taxes, Insurance and Expenses (or components thereof) for all or any such buildings and structures, and any common areas and facilities operated or maintained in
connection therewith and all parcels or tracts of land on which all or any portion of any of the other foregoing items are located, in accordance with sound accounting and management practices; provided, Landlord shall reasonably reduce
Tenant’s Share to be based on the ratio of the rentable area of the Premises to the rentable area of all such buildings as to which such Taxes, Insurance and Expenses (or components thereof) are included. In addition, if the Property, or any
development or complex of which it is a part, shall contain non-flex space types of uses (e.g. general office use) during any period, Landlord may determine, in accordance with sound accounting and management practices, Tenant’s Share of Taxes,
Insurance and Expenses (or components thereof) for only the flex space portion of the Property or of such development or complex; in such event, Landlord shall reasonably adjust Tenant’s Share to be based on the ratio of the rentable area of
the Premises to the rentable area of such flex space portion for such period. Tenant acknowledges that the “rentable area of the Premises” under this Lease includes the so-called “usable area,” without deduction for columns or
projections and which may have been measured to the “drip line” or may include patio or balcony space to which Tenant has access, multiplied by one or more load or conversion factors to reflect a share of certain areas, which may include
lobbies, corridors, mechanical, utility, janitorial, boiler and service rooms and closets, restrooms, and other public, common and service areas. Except as provided expressly to the contrary herein, the “rentable area of the Property”
shall include all rentable area of all space leased or available for lease at the Property (excluding any parking facilities). Landlord may reasonably re-determine the rentable area of the Property from time to time to reflect remeasurements,
re-configurations, additions or modifications to the Property, and may reasonably adjust Tenant’s Share prospectively based thereon. 
 ARTICLE 31: OFFER 
 This document shall not be binding on either party
unless and until signed and delivered by both parties. 
 ARTICLE 32: MISCELLANEOUS 
 A. Captions and Interpretation. The captions of the Articles and Paragraphs of this Lease, and any computer highlighting of changes
from earlier drafts, are for convenience of reference only and shall not be considered or referred to in resolving questions of interpretation. Tenant acknowledges that it has read this Lease and that it has had the opportunity to confer with
counsel in negotiating this Lease; accordingly, this Lease shall be construed neither for nor against Landlord or Tenant, but shall be given a fair and reasonable interpretation in accordance with the meaning of its terms. The neuter shall include
the masculine and feminine, and the singular shall include the plural. The term “including” shall be interpreted to mean “including, but not limited to.” 
  

					
		  	31	  	

 B. Survival of Provisions. All obligations (including indemnity, Rent and other
payment obligations) or rights of either party arising during or attributable to the period prior to expiration or earlier termination of this Lease shall survive such expiration or earlier termination. 
 C. Severability. If any term or provision of this Lease or portion thereof shall be found invalid, void, illegal, or unenforceable
generally, or with respect to any particular party, by a court of competent jurisdiction, it shall not affect, impair or invalidate any other terms or provisions or the remaining portion thereof or enforceability with respect to any other party.

 D. Perpetuities. If the Commencement Date is delayed in accordance with Article 2 for more than nine (9) months,
Landlord may declare this Lease terminated by notice to Tenant, and if the Commencement Date is so delayed for more than three years, this Lease shall thereupon be deemed terminated without further action by either party. 
 E. Short Form Lease. This Lease shall not be recorded by any party, but either party or any Lender may elect to record a customary
short form memorandum of this Lease, in which case: (i) the other party shall promptly execute, acknowledge and deliver the same on a customary form prepared by the requesting party and reasonably acceptable to such other party, and
(ii) upon expiration or earlier termination of this Lease, Tenant shall promptly execute, acknowledge and deliver such documentation as Landlord may prepare evidencing the termination of this Lease on a customary form prepared by Landlord and
reasonably acceptable to Tenant. 
 F. Light, Air and Other Interests. This Lease does not grant any legal rights to
“light and air” outside the Premises nor any particular view visible from the Premises, nor any easements, licenses or other interests unless expressly contained in this Lease. 
 G. Authority. Tenant and all Persons signing for Tenant below, and Landlord and all Persons signing for Landlord below, hereby
represent that this Lease has been fully authorized and no further approvals are required, and that Landlord and Tenant are duly organized, in good standing and legally qualified to do business in the Property and Premises (and have any required
certificates, licenses, permits and other such items). 
 H. Partnership Tenant. If Tenant is a partnership, all current
and new general partners shall be jointly and severally liable for all obligations of Tenant hereunder and as this Lease may hereafter be modified, whether such obligations accrue before or after admission of future partners or after any partners
die or leave the partnership. Tenant shall cause each new partner to sign and deliver to Landlord written confirmation of such liability, in form and content satisfactory to Landlord, but failure to do so shall not avoid such liability. 

I. Successors and Assigns; Transfer of Property and Security Deposit. Each of the terms and provisions of this Lease shall be
binding upon and inure to the benefit of the parties’ respective heirs, executors, administrators, guardians, custodians, successors and assigns, subject to Article 13 respecting Transfers and Article 18 respecting rights of Lenders. Subject to
Article 18, if Landlord shall convey or transfer the Property or any portion thereof in which the Premises are contained to another party, such party shall thereupon be and become landlord hereunder, shall be deemed to have fully assumed all of
Landlord’s obligations under this Lease accruing during such party’s ownership, including the return of any Security Deposit, and Landlord shall be free of all such obligations accruing from and after the date of conveyance or transfer.

 J. Limitation of Liability. Tenant agrees to look solely to Landlord’s interest in the Property for the
enforcement of any judgment, award, order or other remedy under or in connection with this Lease or any related agreement, instrument or document or for any other matter whatsoever relating thereto or to the Property or Premises. Under no
circumstances shall any present or future, direct or

  

					
		  	32	  	

 
indirect, principals or investors, general or limited partners, officers, directors, shareholders, trustees, beneficiaries, participants, advisors, managers, employees, agents or affiliates of
Landlord, or of any of the other foregoing parties, or any of their heirs, successors or assigns have any liability for any of the foregoing matters. In no event shall Landlord be liable to Tenant for any consequential damages. Notwithstanding the
foregoing, the parties agree that this provision shall not apply to claims to the extent covered by Landlord’s liability insurance. 
 K. Confidentiality. Tenant shall use commercially reasonable efforts to keep confidential the content and all copies of this Lease, related documents or amendments now or hereafter entered, and all
proposals, materials, information and matters relating thereto, including the results of any review of Landlord’s records under Article 3, and not to disclose, disseminate or distribute any of the same, or permit the same to occur, except on an
“as needed” basis to the extent reasonably required for proper business purposes by Tenant’s employees, attorneys, insurers, auditors, lenders, brokers and Transferees, and except as may be required by Law or court proceedings.

 ARTICLE 33: ENTIRE AGREEMENT 
 This Lease, together with the Exhibits and other documents listed in Article 1 (WHICH ARE HEREBY COLLECTIVELY INCORPORATED HEREIN AND MADE A PART HEREOF AS THOUGH FULLY SET FORTH), contains all the terms
and provisions between Landlord and Tenant relating to the matters set forth herein and no prior or contemporaneous agreement or understanding pertaining to the same shall be of any force or effect, except for any such contemporaneous agreement
specifically referring to and modifying this Lease and signed by both parties. Without limitation as to the generality of the foregoing, Tenant hereby acknowledges and agrees that Landlord’s leasing agents and field personnel are only
authorized to show the Premises and negotiate terms and conditions for leases subject to Landlord’s final approval, and are not authorized to make any agreements, representations, understandings or obligations binding upon Landlord respecting
the condition of the Premises or Property, suitability of the same for Tenant’s business, the current or future amount of Taxes, Insurance or Expenses or any component thereof, the amount of rent or other terms applicable under other leases at
the Property, whether Landlord is furnishing the same utilities or services to other tenants at all, on the same level or on the same basis, or any other matter, and no such agreements, representations, understandings or obligations not expressly
contained herein or in such contemporaneous agreement shall be of any force or effect. TENANT HAS RELIED ON TENANT’S INSPECTIONS AND DUE DILIGENCE IN ENTERING THIS LEASE, AND NOT ON ANY REPRESENTATIONS OR WARRANTIES, EXPRESS OR IMPLIED,
CONCERNING THE HABITABILITY, CONDITION OR SUITABILITY OF THE PREMISES OR PROPERTY FOR ANY PARTICULAR PURPOSE OR ANY OTHER MATTER NOT EXPRESSLY CONTAINED HEREIN. This Lease, including the Exhibits referred to above, may not be modified, except in
writing signed by both parties. 
  

					
		  	33	  	

 IN WITNESS WHEREOF, the parties have executed this Lease as of the date first set forth
above. 
  

					
	LANDLORD:	 	CMD PROPERTIES, INC. [SEAL]
		 	an Illinois corporation
			
		 	By:	 	/s/ Allen D. Aldridge
		 		 	Allen D. Aldridge, Vice President

  

					
	TENANT:	 	StemCo Biomedical, Inc. [SEAL]
		 	a Delaware corporation
			
		 	By:	 	/s/ Jonathan Lawrie
		 	Name:	 	Jonathan Lawrie
		 	Its:	 	President & CEO

 CERTIFICATE 
 I, Kelly Bolick, as Office Manager of the aforesaid Tenant, hereby certify that the individual(s) executing the foregoing Lease on behalf of
Tenant was/were duly authorized to act in his/their capacities as set forth above, and his/their action(s) are the action of Tenant. 
  

					
	 (Corporate Seal)
	 	/s/ Kelly Bolick	  	

 EXHIBIT A: PREMISES 
 (Floor Plate(s) Showing Premises Cross-Hatched) 
  

					
		  		  	

 EXHIBIT B: RULES 
 (1) No Exterior Storage. Nothing shall be stored outside the Premises, unless exterior storage is required by Law and approved in
writing by Landlord in its reasonable discretion. 
 (2) Dust and Fume Control. No wood-shaping or spraying material
processes or any activity creating dust or fumes that may be hazardous shall be performed in the Premises except in an environment controlled by air-handling equipment properly and lawfully designed and utilized, which shall be maintained and
operated at alt times to prevent hazardous accumulations of wood, chemical or other pollutants in the atmosphere within the Premises or Property. 
 (3) Trash. All garbage, refuse, trash and other waste shall be kept in the kind of container, placed in the areas, and prepared for collection in the manner and at the times and places reasonably
specified by Landlord, subject to the provisions of this Lease respecting Hazardous Materials. If Landlord designates a service to pick up such items, Tenant shall use the same (and the cost shall be included in Expenses). Landlord reserves the
right to require that Tenant participate in any recycling program designated by Landlord. 
 (4) Window and Door
Treatments. Tenant shall not place anything or allow anything to be placed in the Premises near the glass of any door, partition, wall or window which may be unsightly from outside the Premises, and Tenant shall not place or permit to be
placed any article of any kind on any window ledge or on the exterior walls. Blinds, shades, awnings or other forms of inside or outside window devices shall not be placed in or about the outside windows or doors in the Premises except to the
extent, if any, that the design, character, shape, color, material and make thereof is first approved or designated by Landlord, Tenant shall not install or remove any solar tint film from the windows. 
 (5) Balconies and Patios. If the Premises has access to a patio or balcony, Tenant shall have a license to enter such area, subject
to the following provisions: (i) Tenant’s access to such area shall be limited to the area immediately adjoining the Premises (and bounded by an extension of the demising lines of the Premises), and Landlord reserves the right to install
materials separating Tenant’s area from the area adjoining other tenants’ premises, (ii) Tenant shall use such area only in a manner that is quiet and compatible with the nature of the Property, which only involves the use of benches
or outdoor furniture approved by Landlord in writing, and which will not bother, disturb or annoy any other occupants of the Property, and (iii) Tenant’s use thereof shall be subject to the other provisions of this Lease, including the
other Rules, 
 (6) Lighting and General Appearance of Premises. Landlord reserves the right to designate and/or approve
in writing all internal lighting that may be visible from the public, common or exterior areas. The design, arrangement, style, color, character, quality and general appearance of the portion of the Premises visible from public, common and exterior
areas, and contents of such portion of the Premises, including furniture, fixtures, signs, art work, wall coverings, carpet and decorations, and all changes, additions and replacements thereto shall at all times have a neat, professional,
attractive, first class appearance. 
 (7) Use of Common Areas; No Soliciting. Tenant shall not use the common areas,
including areas adjacent to the Premises, for any purpose other than ingress and egress, and any such use thereof shall be subject to the other provisions of this Lease, including these Rules. Without limiting the generality of the foregoing, Tenant
shall not allow anything to remain in any passageway, sidewalk, court, corridor, stairway, entrance, exit, elevator, parking or shipping area, or other area outside the Premises. Tenant shall not use the common areas to canvass, solicit business or
information from, or distribute any article or material to, other tenants or invitees of the Property. Tenant shall not make any room-to-room canvass to solicit business or information or to distribute any article or material to or from other
tenants of the Property and shall not exhibit, sell or offer to sell, use, rent or exchange any products or services in or from the Premises unless ordinarily embraced within the Tenant’s use of the Premises expressly permitted in the Lease.
Landlord shall in all cases retain the right to control and prevent access to such areas by Persons engaged in activities which are illegal or violate these Rules, or whose presence in the judgment of Landlord shall be prejudicial to the safety,
character, reputation and interests of the Property and its tenants (and Landlord shall have no liability for such actions taken in good faith). 
  

					
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 (8) Plumbing Equipment. Toilet rooms, urinals, wash bowls, drains, sewers and other
plumbing fixtures, equipment and lines shall not be misused or used for any purpose other than that for which they were constructed and no foreign substance of any kind whatsoever shall be disposed of therein. 
 (9) Roof; Awnings and Projections. Tenant shall not install any sign, antennae, satellite dish or any other device on the roof, or
common areas of the Property. Tenant may install and have access to rooftop HVAC equipment only to the extent approved or required by Landlord from time to time in connection with Tenant’s maintenance, repair or HVAC obligations under this
Lease. No awning or other projection shall be attached by or for Tenant to the exterior walls of the Premises or the Building. 
 (10) Signs. Landlord may prescribe the suite number for the Premises and cause building standard suite identification signage to be placed on or adjacent to the main entrance door of the Premises. Landlord shall bear the expense of
any such initial building standard signage, and Tenant shall pay Landlord’s standard charges for changes requested by Tenant and approved by Landlord thereafter promptly after billing thereof. Tenant shall not paint, display, inscribe, maintain
or affix any sign, placard, picture, advertisement, name, notice, lettering or direction on any part of the outside or inside of the Property, or on any part of the inside of the Premises which can be seen from the outside of the Premises, without
the prior consent of Landlord, and then only such name or names or matter arid in such color, size, style, character and material, and with professional designers, fabricators and installers as may be first approved or designated by Landlord in
writing. Landlord reserves the right, without notice to Tenant, to remove at Tenant’s expense all matter not so installed or approved. If Landlord approves of any Tenant sign, then such sign shall: (i) be professionally designed, prepared
and installed, (ii) be in good taste so as not to detract from the general appearance of the Premises or the Property, (iii) not advertise any product, and (iv) comply with any sign criteria developed by Landlord from time to time.
All signs hereunder shall be subject to all Laws and any covenants, conditions and restrictions applicable to the Property or Building. Tenant shall maintain any Tenant signs approved hereunder in good repair and sightly first class condition.

 (11) Parking. Parking of cars shall be available in areas designated generally for tenant parking, if any, on a
“first come”, “first served” unassigned basis in common with Landlord, other tenants and other parties to whom parking privileges have been or are hereafter granted. At Landlord’s option from time to time, Tenant shall not
exceed its percentage share of such available parking spaces based on the ratio of the rentable area of the Premises to the rentable area of the Building. Parking is prohibited in areas: (1) not striped or designated for parking,
(2) aisles, (3) where “no parking” signs are posted, (4) on ramps, and (5) loading areas and other specially designated areas. Delivery trucks and vehicles shall use only those areas designated therefor. Landlord
reserves the right to: (i) assign specific spaces, and reserve spaces for small cars, disabled individuals, and other tenants, customers of tenants or other parties (and Tenant shall not park in any such assigned or reserved spaces) and
(ii) restrict or prohibit full size vans and other large vehicles. In case of any violation of these provisions or any applicable Laws, Landlord may: (a) refuse to permit the violator to park, and remove the vehicle owned or driven by the
violator from the Property without liability whatsoever, at such violator’s risk and expense and/or (b) charge Tenant such reasonable rates as Landlord may from time to time establish for such violations, which shall be at least $100.00
per day for each vehicle that is parked in violation of these Rules. These provisions shall be in addition to any other remedies available to Landlord under this Lease or otherwise. 
 (12) Overloading Floors. Tenant shall not overload any floor in the Premises or Property. 
 (13) Going-Out-Of-Business Sates and Auctions. Tenant shall not use, or permit any other party to use, the Premises for any distress,
fire, bankruptcy, close-out, “lost our lease” or going-out-of-business sale or auction. Tenant shall not display any signs advertising the foregoing anywhere in or about the Premises. This prohibition shall also apply to Tenant’s
creditors. 
  

					
		  	2	  	

 (14) Labor Harmony. Tenant shall not use (and upon notice from Landlord shall cease
using) contractors, services, workmen, labor, materials or equipment, or labor and employment practices that, in Landlord’s good faith judgment, may cause strikes, picketing or boycotts or disturb labor harmony with the workforce or trades
engaged in performing other work, labor or services in or about the Property. 
 (15) Responsibility for Compliance.
Tenant shall be responsible for ensuring compliance with these Rules, as they may be amended, by Tenant’s employees and as applicable, by Tenant, any other occupant of the Premises, and their respective agents, employees, invitees, Transferees
and contractors. 
 (16) Property Tradename, Likeness, Trademarks. Tenant shall not in any manner use the name of the
Property for any purpose other than as Tenant’s business address, or use any tradenames or trademarks of Landlord, any other tenant, or their affiliates, or any picture or likeness of the Property, for any purpose, in any letterheads,
circulars, notices, advertisements or other material whatsoever. 
 (17) Deliveries and Removals. Tenant shall not take
or permit to be taken in or out of other entrances or elevators of the Property any item normally taken, or which Landlord otherwise reasonably requires to be taken, in or out through service doors or on freight elevators. Landlord may impose
reasonable requirements for the use of freight elevators and loading areas, and reserves the right to alter schedules without notice. Any hand-carts used at the Property shall have rubber wheels and sideguards, and no other material-handling
equipment may be used without Landlord’s prior written approval. 
 (18) Locks and Keys. Tenant shall use such
standard key system designated by Landlord on all keyed doors to and within the Premises, excluding any permitted vaults or safes (but Landlord’s designation shall not be deemed a representation of adequacy to prevent unlawful entry or criminal
acts, and Tenant shall maintain such additional insurance as Tenant deems advisable for such events). Tenant shall not attach or permit to be attached additional locks or similar devices to any door or window, change existing locks or the mechanism
thereof, or make or permit to be made any keys for any door other than those provided by Landlord. If more than two keys for one lock are desired, Landlord will provide them upon payment of Landlord’s charges. In the event of loss of any keys
furnished by Landlord, Tenant shall pay Landlord’s reasonable charges therefor. The term “key” shall include mechanical, electronic or other keys, cards and passes. 
 (19) Safety And Security Devices, Services And Programs. Safety and security devices, services and programs provided by Landlord, if
any, while intended to deter crime and ensure safety, may not in given instances prevent theft or other criminal acts, or ensure safety of persons or property. The risk that any safety or security device, service or program may not be effective, or
may malfunction, or be circumvented by a criminal, is assumed by Tenant with respect to Tenant’s property and interests, and Tenant shall obtain insurance coverage to the extent Tenant desires protection against such criminal acts and other
losses, as further described in Article 10. Tenant agrees to cooperate in any reasonable safety or security program developed by Landlord or required by Law. 
 (20) Utility Closets and Connections. Landlord reserves the right to control access to and use of, and monitor and supervise any work in or affecting, the “wire” or telephone, electrical,
plumbing or other utility closets, the Systems and Equipment, and any changes, connections, new installations, and wiring work relating thereto (or Landlord may engage or designate an independent contractor to provide such services). Tenant shall
obtain Landlord’s prior written reasonable consent for any such access, use and work in each instance, and shall comply with such requirements as Landlord may reasonably impose, and the other provisions of Article 6 respecting electric
installations and connections, Article 28 respecting telephone Lines and connections, and Article 9 respecting Work in general. Tenant shall have no right to use any broom closets, storage closets, janitorial closets, or other such closets, rooms
and areas whatsoever. Tenant shall not install in or for the Premises any equipment which requires more electric current than Landlord is required to provide under this Lease, without Landlord’s prior written approval, and Tenant shall
ascertain from Landlord the maximum amount of load or demand for or use of electrical current which can safety be permitted in and for the Premises, taking into account the capacity of electric wiring in the Property and the Premises and the needs
of tenants of the Property, and shall not in any event connect a greater load than such safe capacity. 
  

					
		  	3	  	

 (21) Alcohol, Drugs, Food and Smoking. Landlord reserves the right to exclude or
expel from the Property any person who, in the judgment of Landlord, is intoxicated or under the influence of liquor or drugs, or who shall in any manner do any act in violation of any of these Rules. Tenant shall not at any time manufacture, sell,
use or give away, any spirituous, fermented, intoxicating or alcoholic liquors on the Premises, nor permit any of the same to occur. Tenant shall not at any time cook, sell, purchase or give away, food in any form by or to any of Tenant’s
agents or employees or any other parties on the Premises, nor permit any of the same to occur (other than in microwave ovens and coffee makers properly maintained in good and safe working order and repair in lunch rooms or kitchens for employees as
may be permitted or installed by Landlord, and which do not violate any Laws or bother or annoy any other tenant). Tenant and its employees shall not smoke tobacco on any part of the Property (including exterior areas) except those areas, if any,
that are designated or approved as smoking areas by Landlord. 
 (22) Energy and Utility Conservation. Tenant shall not
waste electricity, water, heat or air conditioning or other utilities or services, and agrees to cooperate fully with Landlord to assure the most effective and energy efficient operation of the Property. 
 (23) Unattended Premises. Before leaving the Premises unattended, Tenant shall close and securely lock all doors or other means of
entry to the Premises and shut off all lights and water faucets in the Premises (except heat to the extent necessary to prevent the freezing or bursting of pipes). 
 (24) Prohibited Activities. Tenant shall not: (i) use strobe or flashing lights in or oh the Premises, (ii) install or operate any internal combustion engine, boiler, machinery,
refrigerating, heating or air conditioning equipment in or about the Premises, except with Landlord’s express written approval, (iii) use the Premises for housing, lodging or sleeping purposes or for the washing of clothes, (iv) place
any radio or television antennae other than inside of the Premises, (v) operate or permit to be operated any musical or sound producing instrument or device which may be heard outside the Premises, (vi) use any source of power other than
electricity, (vii) operate any electrical or other device from which may emanate electrical, electromagnetic, x-ray, magnetic resonance, energy, microwave, radiation or other waves or fields which may interfere with or impair radio, television,
microwave, or other broadcasting or reception from or in the Property or elsewhere, or impair or interfere with computers, faxes or telecommunication lines or equipment at the Property or elsewhere, or create a health hazard, (viii) bring or
permit any bicycle or other vehicle, or dog (except in the company of a blind person or except where specifically permitted) or other animal or bird in the Property, (ix) make or permit objectionable noise, vibration or odor to emanate from the
Premises, (x) do anything in or about the Premises or Property that is illegal, immoral, obscene, pornographic, or anything that may in Landlord’s good faith opinion create or maintain a nuisance, cause physical damage to the Premises or
Property, interfere with the normal operation of the Systems and Equipment, impair the appearance, character or reputation of the Premises or Property, create waste to the Premises or Property, cause demonstrations, protests, loitering, bomb threats
or other events that may require evacuation of the Building, (xi) throw or permit to be thrown or dropped any article from any window or other opening in the Property, (xii) use the Premises for any purpose, or permit upon the Premises or
Property anything, that may be dangerous to persons or property (including firearms or other weapons (whether or not licensed or used by security guards) or any explosive or combustible articles or materials), (xiii) place vending or game
machines in the Premises, except vending machines for employees, (xiv) adversely affect the indoor air quality of the Premises or Property, or (xv) do or permit anything to be done upon the Premises or Property in any way tending to
disturb, bother, annoy or interfere with Landlord or any other tenant at the Property or the tenants of neighboring property, or otherwise disrupt orderly, quiet use and occupancy of the Property. 
 (25) Responsibility for Compliance. Tenant shall be responsible for ensuring compliance with these Rules, as they may be amended, by
Tenant’s employees and as applicable, by Tenant’s agents, invitees, contractors, subcontractors, and suppliers. Tenant shall cooperate with any reasonable program or requests by Landlord to monitor and enforce the Rules, including
providing vehicle numbers and taking appropriate action against such of the foregoing parties who violate these provisions. 
  

					
		  	4	  	

					
	 	 	EXHIBIT C	 	 
		 		 	

 EXTENSION OPTION 
 1. Option to Extend. Subject to the other provisions hereof, Landlord hereby grants Tenant one option (“Extension
Option”) to extend the current Term of the Lease for an additional period of three (3) consecutive years from the expiration of the prior period (“Extension Period”), on the same terms and conditions then in effect
under this Lease immediately prior to the Extension Period, except as modified by the “Market Rates, Terms and Conditions” further described below, and Tenant shall have no further option to extend. Tenant may exercise the Extension Option
only by giving Landlord written notice thereof (“Tenant’s Exercise Notice”) no earlier than fourteen (14) and no later than nine (9) full calendar months prior to commencement of the subject Extension Period.
Tenant’s Exercise Notice shall be unconditional and irrevocable (except as expressly provided herein). 
 2.
Landlord’s Notice of Market Rates, Terms and Conditions; Disagreement. Within ten (10) business days after receiving Tenant’s Exercise Notice, Landlord shall provide Tenant with notice (“Landlord’s Notice”)
of the Market Rates, Terms and Conditions, subject to the other provisions hereof. The term “Market Rates, Terms and Conditions” herein shall mean Landlord’s good faith determination of fair market Base Rent and other terms and
conditions (including, but not limited to any scheduled increases in Base Rent, any base years or stops for taxes or expenses, and any improvements or an allowance therefor) for renewing the Lease for the Premises during the Extension Period, taking
into account comparable renewals of comparable tenants of comparable financial condition in comparable non-sublease space in comparable buildings in the same market area. If the Market Rates, Terms and Conditions determined by Landlord are
acceptable to Tenant, then Tenant shall confirm its exercise of the Extension Option by notice (“Tenant Confirmation Notice”) to Landlord confirming such acceptance given no later than fifteen (15) days after Landlord’s
Notice. However, if the Market Rates, Terms and Conditions determined by Landlord are not acceptable to Tenant, then Tenant may, no later than fifteen (15) days after Landlord’s Notice, deliver to Landlord a notice (“Tenant’s
Market Notice”) of Tenant’s good faith determination of the Market Rates, Terms and Conditions and reasons therefor. If Tenant provides a timely Tenant’s Market Notice, the parties shall seek to agree on the Market Rates, Terms
and Conditions in the form of a non-binding letter of intent (“Letter of Intent”) during the period (“Negotiation Period”) ending forty-five (45) days after Landlord’s Notice. If Tenant delivers a timely
Tenant Confirmation Notice, or if the parties enter into the Letter of Intent concerning the Market Rates, Terms and Conditions during the Negotiation Period, then the parties shall seek reasonably and in good faith to agree on and enter into a
mutually acceptable formal written extension amendment to the Lease (“Extension Amendment”) setting forth the final and definitive Market Rates, Terms and Conditions and other mutually acceptable provisions for the Lease extension
during the period ending sixty (60) days after Landlord’s Notice (“Documentation Period”). Tenant shall be deemed to have revoked its exercise of the Extension Option, and the Extension Option and Tenant’s exercise
thereof shall be null and void if: (a) Tenant fails to provide a timely Tenant Confirmation Notice or Tenant’s Market Notice, or (b) the parties fail to enter into the Letter of Intent within the Negotiation Period, or (c) the
parties fail to mutually sign and deliver the Extension Amendment within the Documentation Period. 
 3. General Matters.
The Extension Option herein shall, at Landlord’s election, be conditioned on the Lease being in full force and effect, and Tenant not then being in default beyond any applicable cure period under the Lease, at the time Tenant seeks to exercise
the Extension Option, or at any time thereafter and prior to commencement of the Extension Period. If Tenant shall fail to properly and timely exercise the Extension Option, then the Extension Option shall thereupon terminate. STRICT COMPLIANCE AND
TIMELINESS IN GIVING TENANTS NOTICES AND SIGNING THE EXTENSION AMENDMENT HEREUNDER IS OF THE ESSENCE OF THIS PROVISION. The rights granted in this Exhibit are personal to Tenant and its Tenant Affiliates (as hereinafter defined) as named in this
Lease document. Under no circumstance whatsoever shall the assignee under a complete or partial assignment of the Lease document (other than a complete assignment to a Tenant Affiliate), or a subtenant under a sublease of the Premises, have any
right to exercise the rights of Tenant under this Exhibit. If Tenant shall sublease or assign the Lease with respect to all or any portion of the Premises (other than to a Tenant Affiliate), then immediately upon such sublease or assignment
Tenant’s rights under this Exhibit shall concurrently terminate and

 
become null and void. The Extension Option shall be subordinate to, and limited by, any rights of any other parties to expand into or lease the Premises granted prior to full execution and
delivery of this Lease document. The term “Tenant Affiliate” as used herein shall mean any party which directly or indirectly: (i) wholly owns or controls Tenant, (ii) is wholly owned or controlled by Tenant, or (iii) is
under common ownership or control with Tenant, or (iv) into which Tenant is merged, consolidated or reorganized, or to which all or substantially all of Tenant’s assets are sold. 
  

					
		  	2	  	

					
		 	EXHIBIT D	 	
		 		 	
		 	RIGHT OF OFFER	 	

 1. Right of Offer. Landlord hereby grants Tenant a right of offer
(“Right Of Offer”) to lease the space shown on Exhibit A, currently known as Suite 152 (the “Expansion Space”), which shall be deemed to contain 5,293 square feet of rentable area for current purposes hereof,
all on and subject to the following provisions; provided, this Right of Offer and Landlord’s obligation to provide a “Landlord Notice” shall be in effect commencing on the date that this Lease has been executed and delivered by both
parties. 
 2. Landlord’s Notice of Expansion Terms. While this Right of Offer is in effect, Landlord shall notify
Tenant in writing (“Landlord’s Notice”): (i) within thirty (30) days after the Expansion Space becomes legally available to lease, or (ii) at such earlier time as Landlord shall be in a position to project when
the Expansion Space will be legally available to lease, advising Tenant of such projected date, or (iii) at any time thereafter but prior to leasing the Expansion Space to another party. Landlord’s Notice shall set forth the terms
(“Expansion Terms”) on which Landlord proposes to lease the Expansion Space to Tenant, including, but not limited to, a date for the commencement of the lease thereof (“Expansion Space Commencement Date”), an
expiration date therefor or whether the term therefor will be co-terminous with the Term of this Lease, rentable area, monthly base rent and any scheduled increases therein, Tenant’s share of taxes, expenses and other such items (and any base
year or stop level therefor), any tenant improvements or allowance therefor, and any other terms and conditions, as determined in Landlord’s good faith discretion, taking into account comparable expansion terms generally being provided for
comparable tenants of comparable financial condition for comparable non-sublease space in comparable buildings in the vicinity for time periods that are substantially the same as the period of time during which the Expansion Space will be leased to
Tenant. Except as set forth in Landlord’s Notice, the Expansion Terms shall be deemed to include the same terms then in effect on the Expansion Space Commencement Date, and thereafter scheduled to be in effect, under the Lease (with any matters
in the Lease based on square footage adjusted proportionately to reflect the rentable area of the Expansion Space and Landlord’s then current Building-standard ratios and policies). 
 3. Tenant’s Notice and Financial Information. If Tenant desires to lease the Expansion Space on the Expansion Terms set forth in
Landlord’s Notice, Tenant shall so notify Landlord in writing (“Tenant’s Notice”) exercising Tenant’s right to lease the Expansion Space on such Expansion Terms within five (5) business days after Landlord sends
Landlord’s Notice. Tenant’s Notice shall be unconditional and irrevocable. In order to be effective, Tenant’s Notice shall include financial information for Tenant’s business comparable to the information provided in connection
with entering into this Lease document. If Landlord determines in good faith that Tenant’s financial condition is materially worse than the condition that Landlord accepted when the parties entered into this Lease document, Landlord may
withdraw Landlord’s Notice and the Right of Offer, or provide a new Landlord’s Notice with reasonably modified Expansion Terms or reasonable additional security requirements taking into account Tenant’s financial condition.

 4. Expansion Documentation; Failure to Exercise Right Of Offer or to Sign Expansion Documentation. If Tenant validly
exercises Tenant’s Right Of Offer herein, Landlord shall prepare an amendment (“Expansion Documentation”) on Landlord’s then standard form which shall set forth the final and definitive terms and conditions upon which
Landlord proposes to lease the Expansion Space to Tenant, and which shall be generally consistent with Landlord’s Notice. If Tenant desires to lease the Expansion Space on the basis of such Expansion Documentation, Tenant shall execute and
deliver the Expansion Documentation to Landlord within ten (10) days after Landlord provides the Expansion Documentation to Tenant. Once Tenant provides Tenant’s Notice exercising Tenant’s Right of Offer, Landlord shall have no
further obligation to provide a Landlord’s Notice respecting the Expansion Space included in Landlord’s Notice (provided, this Right of Offer shall continue to apply to any portions of the Expansion Space that were not included in
Landlord’s Notice as further provided below). If Tenant fails to validly exercise such Right Of Offer, or fails to sign and deliver the Expansion Documentation to Landlord, strictly in accordance with the terms hereof, such Right Of Offer shall
be deemed to have lapsed and

  

					
		  	1	  	

 
expired as to the Expansion Space that was included in Landlord’s Notice, and Landlord may thereafter freely lease all or a portion of the Expansion Space that was included in
Landlord’s Notice to any other party, at any time, on any terms, in Landlord’s sole discretion; provided, despite Tenant’s waiver, this Right of Offer shall continue to apply to any portions of the Expansion Space that were not
included in Landlord’s Notice as further provided below. TIME PERIODS AND STRICT COMPLIANCE IN GIVING TENANT’S NOTICE, AND IN TENANT’S SIGNING AND DELIVERING THE EXPANSION DOCUMENTATION, ARE OF THE ESSENCE OF THIS RIGHT OF
OFFER. 
 5. Offering Portions of Expansion Space; Adjustments to Expansion Space; Prior Rights. This Right Of Offer
shall apply only with respect to the entire Expansion Space, and may not be exercised with respect to only a portion thereof (unless only a portion of the Expansion Space shall be included in Landlord’s Notice). If only a portion of the
Expansion Space shall be included in Landlord’s Notice, this Right of Offer shall apply to such portion, and shall thereafter apply to such other portions of the Expansion Space as they become the subject of Landlord’s Notices, subject to
good faith adjustments by Landlord in the size, configuration and location of such remaining portions. If the Expansion Space is part of a larger space that Landlord desires to lease as a unit, then Landlord’s Notice shall, at Landlord’s
option, identify the entire such space and the Expansion Terms therefor, and in such case, this Right Of Offer shall apply only to such entire space. Landlord reserves the right at any time prior to sending, or as part of, Landlord’s Notice, to
substitute for the Expansion Space other space (herein referred to as the “new expansion space”) in the Building or another building in the same complex or in the vicinity, provided the new expansion space shall be similar to the Expansion
Space in size (up to 10% larger or smaller); at Landlord’s option, the new expansion space may overlap with and include a portion of the then current Expansion Space. This Right Of Offer shall be subject to the then existing tenants or
occupants of the Expansion Space renewing their existing leases whether pursuant to options to extend previously granted or otherwise, and such Right Of Offer, and any rights of Tenant to extend the Term of the Lease with respect to the Expansion
Space, are subordinate to, and limited by, any rights of any other parties to lease the Expansion Space granted prior to full execution and delivery of this document. 
 6. Miscellaneous. This Right Of Offer is subject to the condition that the Lease be in full force and effect, and that Tenant not then be in default beyond any applicable cure period under the
Lease on the date when Landlord provides or would otherwise provide Landlord’s Notice, or at any time thereafter and prior to the Expansion Space Commencement Date. The rights granted in this Exhibit are personal to Tenant and its Tenant
Affiliates (as hereinafter defined) as named in this Lease document. Under no circumstance whatsoever shall the assignee under a complete or partial assignment of the Lease document (other than a complete assignment to a Tenant Affiliate), or a
subtenant under a sublease of the Premises, have any right to exercise the rights of Tenant under this Exhibit. If Tenant shall sublease or assign the Lease with respect to all or any portion of the Premises (other than to a Tenant Affiliate), then
immediately upon such sublease or assignment Tenant’s rights under this Exhibit shall concurrently terminate and become null and void. The term “Tenant Affiliate” as used herein shall mean any party which directly or indirectly;
(i) wholly owns or controls Tenant, (ii) is wholly owned or controlled by Tenant, or (iii) is under common ownership or control with Tenant, or (iv) into which Tenant is merged, consolidated or reorganized, or to which all or
substantially all of Tenant’s assets are sold. If Tenant shall exercise the Right Of Offer herein, Landlord does not guarantee to deliver possession of the Expansion Space on the Expansion Space Commencement Date due to continued possession by
the then existing occupants or any other reason beyond Landlord’s reasonable control. In such event, rent and other charges with respect to the Expansion Space shall be abated until Landlord delivers the same to Tenant (except to the extent
that Tenant or its affiliates, agents, employees or contractors cause the delay), as Tenant’s sole recourse. Tenant’s exercise of this Right of Offer is intended to supersede any rights of Tenant under the Lease to reduce or relocate the
Premises, or terminate the Lease early, and all such provisions shall thereupon be automatically deleted. 
  

					
		  	2	  	

					
		 	EXHIBIT E	 	

 OPTION TO TERMINATE 
 Tenant shall have a one-time option to terminate this Lease effective on December 31, 2006 (“Early Termination Date”)
as though such date were the original expiration date set forth in this Lease, but only by complying strictly with the following conditions: (i) Tenant shall deliver to Landlord written notice (Tenant’s Exercise Notice”)
exercising such option no later than February 28, 2006 (“Latest Exercise Date”), (ii) Tenant shall timely pay the cancellation payment as hereinafter described (“Cancellation Payment”), as a cancellation
fee and not as liquidated damages or a penalty, and (iii) Tenant shall continue to timely pay all rentals and other charges under the Lease and comply with each and every term and provision hereof accruing through the Early Termination Date
(and all such obligations accruing through the Early Termination Date shall survive such termination, including, but not limited to, any rentals or other charges not yet determined or billed prior to the Early Termination Date). 
 Following receipt of Tenant’s Exercise Notice, Landlord shall provide Tenant with a notice (“Landlord’s Unamortized
Improvement Costs Notice”) setting forth a calculation of all unamortized costs of tenant improvements (collectively referred to as “Unamortized Improvement Costs”) theretofore incurred by Landlord in connection with
entering this Lease (including the Allowance as provided in Article 4) and any amendment adding space or modifying the Premises, including, but not limited to, the cost of all allowance and other tenant improvements paid for by Landlord. Such
amortization shall be calculated on a straight-line basis over the period from the date or dates such costs or concessions were incurred or commenced through the expiration date then otherwise scheduled to be in effect under the Lease, with interest
at the rate of ten percent (10%) per annum, alt as reasonably determined by Landlord. Tenant shall pay such Unamortized Improvement Costs as set forth in Landlord’s Unamortized Improvement Costs Notice by check in good funds within fifteen
(15) days after the date of Landlord’s Unamortized Improvement Costs Notice, as a condition to the effectiveness of Tenant’s exercise of Tenant’s early termination option herein. 
 The option herein is personal to the original Tenant named in this Lease and its Tenant Affiliates as hereinafter defined. Under no
circumstances whatsoever shall the assignee under a complete or partial assignment of the Lease (other than a Tenant Affiliate), or a subtenant under a sublease of the Premises, have any right to exercise the option herein. If Tenant shall sublease
or assign the Lease with respect to all or any portion of the Premises (other than to a Tenant Affiliate), then immediately upon such sublease or assignment Tenant’s rights under this Exhibit shall concurrently terminate and become null and
void. The term “ Tenant Affiliate “ as used herein shall mean any party which directly or indirectly: (i) wholly owns or controls Tenant, (ii) is wholly owned or controlled by Tenant, or (iii) is under common ownership or
control with Tenant, or (iv) into which Tenant is merged, consolidated or reorganized, or to which all or substantially ail of Tenant’s assets are sold. Tenant’s exercise of such option shall not operate to cure any violation by
Tenant of any of the terms or provisions in the Lease, nor to extinguish or impair any rights or remedies of Landlord arising by virtue of such violation. Notwithstanding anything contained herein to the contrary, Tenant’s option hereunder
shall, at Landlord’s election, terminate and become null and void if: (a) Tenant is in violation of the Lease at the time Tenant seeks to exercise such option, or at any time thereafter and prior to the Early Termination Date (or if
Tenant’s Cancellation Payment hereunder is returned for insufficient funds), or (b) Tenant leases additional space in the Property, whether pursuant to an expansion right contained in the Lease or otherwise. TIME IS OF THE ESSENCE IN
GIVING TENANT’S EXERCISE NOTICE AND MAKING THE CANCELLATION PAYMENT HEREUNDER. 

 LEASE AMENDMENT ONE 
 (Extension of Term with Allowance) 
 THIS LEASE
AMENDMENT ONE (“Amendment”) is made as of the 23rd day of March, 2007, between Prince Properties, Inc. (“Landlord”), an Illinois corporation, formerly known as CMD Properties, Inc., and Aldagen, Inc.
(“Tenant”), a Delaware corporation, formerly known as Stemco Biomedical, Inc. 
 A. Landlord and Tenant are the
current parties to that certain Standard Lease (“Original Lease”) dated June             , 2003, for premises (“Premises”) in the building
(“Building”) known as 2810 Meridian, located at 2810 Meridian Parkway, Durham, North Carolina (“Property”) (as amended herein, the “Lease”). 
 B. The parties mutually desire to amend the Lease on the terms hereof. 
 NOW THEREFORE, in consideration of the mutual agreements herein contained, the parties hereby agree as follows. 
 1. Extension of Term. The term of the Lease is hereby modified to extend for a period (“Extended Term”)
commencing on May 1, 2008 (“Extension Date”) and expiring on April 30, 2013 (“New Expiration Date”), unless sooner terminated in accordance with its terms. 
 2. Base Rent. The Lease is amended to provide that Base Rent shall be $9,534.00. per month through April 30, 2008; i.e.,
there shall be no increase in Base Rent on May 1, 2007, notwithstanding anything in the Original Lease to the contrary. Commencing on the Extension Date, Tenant shall pay monthly Base Rent as set forth in the following schedule: 
  

				
	 Period
	  	Monthly Base Rent
	 Extension Date - April 30, 2009
	  	$	9,817.87
	 May 1, 2009 - April 30, 2010
	  	$	10,111.77
	 May 1 ,2010 - April 30, 2011
	  	$	10,414.85
	 May 1, 2011 - April 30, 2012
	  	$	10,727.11
	 May 1, 2012 - New Expiration Date
	  	$	11,048.55

 3. HVAC Maintenance. Effective on the Extension Date, in line 3 of the
second paragraph of Article 8.B, the number “$200” is deleted and “$300” is inserted therein. 
 4.
Taxes, Insurance and Expenses. Commencing on the Extension Date, Tenant shall continue to pay Tenant’s Share of Taxes, Insurance and Expenses as provided in the Lease. 
 5. Prorations. If the Extension Date does not occur at the beginning, or the New Expiration Date does not occur at the end, of
an applicable payment period under the Lease, Landlord shall reasonably pro rate Tenant’s payment obligations on a per diem basis; Tenant shall remain liable for all amounts accruing or relating to the period prior to the Extension Date, and
through the New Expiration Date, whether or not theretofore billed. 

 6. Condition of Premises; Improvement Allowance. Tenant has been occupying the
Premises, and agrees to accept the same “AS IS” without any agreements, representations, understandings or obligations on the part of Landlord to perform or pay for any alterations, repairs or improvements, except as expressly provided
herein. 
 (a) Allowance for Tenant Work. Notwithstanding the foregoing, Landlord shall provide an
allowance (“Allowance”) of up to $143,273.00 to be used towards: (i) Tenant’s reasonable, direct out-of-pocket costs of designing and performing permanent leasehold improvements, including the “clean room” (and
all permanent leasehold improvements associated with the clean room) previously installed by Tenant (“Work”) in the Premises, and (ii) reasonable out-of-pocket costs, if any, paid by Landlord to third parties in connection with
the Work. Tenant shall engage its own designers and contractors for the Work as described below, and Landlord shall reimburse Tenant based on Tenant’s submission of a customary tenant’s affidavit respecting the Work, invoices, paid
receipts and other reasonable evidence of payment, and the submission of customary architect’s certificates, lien waivers and affidavits of payment, all reasonably satisfactory to Landlord. If Tenant does not use the entire Allowance for the
purposes permitted herein, or does not submit the foregoing documentation to Landlord, by August 31, 2007, then Landlord shall be entitled to the savings and Tenant shall receive no credit therefor. Any personal property, trade fixtures or
equipment, including, but not limited to, modular or other furniture, and cabling or other items for communications or computer systems, whether or not shown on any plan approved by Landlord, shall be provided by Tenant, at Tenant’s sole cost.

 (b) Tenant Work Procedures. Tenant shall cause all Work hereunder, as well as any further
alterations or improvements by Tenant, to be performed: (i) by architects, engineers, and contractors reasonably approved by Landlord in writing, (ii) in accordance with plans, specifications, and other matters reasonably approved by
Landlord in writing, (iii) in a first class, professional and workmanlike manner, (iv) with materials that are consistent with, or better than, the quality of the Premises and Property, and which are new and free of material defects,
(v) so as not to adversely affect the Property systems and equipment or the structure of the Property, (vi) with reasonable diligence to completion and so as to avoid disturbance, disruption or inconvenience to other tenants and the
operation of the Property, and (vii) in compliance with all legal requirements, all applicable provisions of the Lease, including Article 9 of the Original Lease, and such other reasonable requirements as Landlord may reasonably impose
concerning the manner and times in which such Work shall be done. Any floor, wall or ceiling coring work or penetrations or use of noisy or heavy equipment which may interfere with the conduct of business by other tenants at the Property shall, at
Landlord’s reasonable option, be performed at times other than Landlord’s regular building hours. 
 7.
Landlord’s Notice Address. The addresses for notices or documents delivered to Landlord set forth in the Lease are hereby deleted, and the following are substituted therefor: Prince Properties, Inc., c/o Wind Realty Partners,
12201 Merit Drive, Suite 175, Dallas, Texas 75251, Attn.: Asset Manager; with copies to: Prince Properties, Inc., c/o Wind Realty Partners, 101 North Wacker Drive, Suite 2002, Chicago, Illinois 60606, Attn: Asset Manager and National Property
Manager, and to: DLA Piper US LLP, 203 N. LaSalle Street, Suite 1900, Chicago, IL 6060M293, Attn: Randal J. Selig 
  

 2 

 8. Other Terms; Certain Provisions Deleted. All provisions of the Lease
currently in effect or scheduled to become effective shall remain in effect and become effective in accordance with their terms, except to the extent inconsistent herewith or provided to the contrary herein, and except for any provisions which by
their express terms have lapsed, are scheduled to lapse, or were to be in effect only during the initial Term or other period (in which case such express terms shall govern the periods during which such provisions were, or will remain, in effect),
Notwithstanding the foregoing, this Amendment is intended to supersede any rights of Tenant to extend or renew the term, expand, reduce or relocate the Premises, lease additional space, or terminate the Lease early, and all such provisions are
hereby deleted. 
 9. Confidentiality. Tenant shall keep confidential the content and all copies of this document
and the Lease, related documents now or hereafter entered, and all proposals and matters relating thereto, except to the extent reasonably required on a legitimate “need to know” basis in connection with Tenant’s business by its
employees, insurers, auditors, attorneys, and existing or prospective lenders, successors and assigns, or by law or court proceedings. 
 10. Real Estate Brokers. Tenant hereby represents to Landlord that Tenant has not dealt with any broker, salesperson, agent or finder in connection with this Amendment, except CB Richard Ellis (representing Landlord) and
Colliers Pinkard (representing Tenant), and agrees to defend, indemnify and hold Landlord, and its employees, agents and affiliates harmless from all liabilities and expenses (including reasonable attorneys’ fees and court costs) arising from
any claims or demands of any other broker, salesperson, agent or finder with whom Tenant has dealt for any commission or fee alleged to be due in connection with this Amendment. 
 11. Offer. The submission and negotiation of this Amendment shall not be deemed an offer to enter into the same by
Landlord. This Amendment shall not be binding on Landlord unless and until fully signed and delivered by both parties. Tenant’s execution of this Amendment constitutes a firm offer to enter into the same which may not be withdrawn for a period
of fifteen (15) days after delivery to Landlord. During such period, Landlord may proceed in reliance thereon, but such acts shall not be deemed an acceptance. 
 12. Whole Amendment; Full Force and Effect; Conflicts. This Amendment sets forth the entire agreement between the parties with
respect to the matters set forth herein. There have been no additional oral or written representations or agreements. As amended herein, the Lease shall remain in full force and effect. As an inducement for Landlord to enter into this Amendment,
Tenant hereby represents that Landlord is not in violation of the Lease, and that Landlord has fully performed all of its obligations under the Lease as of the date on which Tenant signs this Amendment. In case of any inconsistency between the
provisions of the Lease and this Amendment, the latter provisions shall govern. 
 13. Interpretation. This
Amendment shall be interpreted in a reasonable manner in conjunction with the Lease. If an Exhibit is attached to this Amendment, the term “Lease” therein shall refer to this Amendment or the Lease as amended, and terms such as
“Commencement Date” and “Lease Term” shall refer to analogous terms in this Amendment,

  

 3 

 
all as the context expressly provides or reasonably implies. Unless expressly provided to the contrary herein: (a) any terms defined herein shall have the meanings ascribed herein when used
as capitalized terms in other provisions hereof, (b) capitalized terms not otherwise defined herein shall have the meanings, if any, ascribed thereto in the Lease, and (c) non-capitalized undefined terms herein shall be interpreted broadly
and reasonably to refer to terms contained in the Lease which have a similar meaning, and as such terms may be further defined therein. 
 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first set forth above. 
  

											
		 		 	LANDLORD:
		 		 	[SEAL]
		 		 	Prince Properties, Inc., an Illinois corporation
		 		 	By: Wind Realty Partners,
		 		 		 		 	an Illinois general partnership, as agent
						
		 		 		 		 	By:	 	/s/ Joseph J. Bowar
		 		 		 		 	Name:	 	Joseph J. Bowar
		 		 		 		 	Its:	 	Senior Vice President

  

									
		 		 	TENANT:
		 		 	[SEAL]
		 		 	Aldagen, Inc.,
		 		 	a Delaware corporation
					
		 		 		 	By:	 	/S/ Edward L Field
		 		 		 	Name:	 	Edward L Field
		 		 		 	Its:	 	President

 CERTIFICATE 
 I,
                                     , as
                                     of the aforesaid Tenant,
hereby certify that the individual(s) executing the foregoing Lease on behalf of Tenant was/were duly authorized to act in his/their capacities as set forth above, and his/their action(s) are the action of Tenant. 
  

			
	(Corporate Seal)             	 	 

 SECOND AMENDMENT TO LEASE AGREEMENT 
 THIS SECOND AMENDMENT TO LEASE AGREEMENT (this “Second Amendment”) is made this 19th day of November, 2008 (the
“Effective Date”), by and between ACP 2810 MERIDIAN LLC, a Delaware limited liability company (“Landlord”), and ALDAGEN, INC. (f/k/a Stemco Biomedical, Inc.), a Delaware corporation (“Tenant”). 

W I T N E S S E T H : 
 A. Pursuant to that certain Standard Lease dated June 24, 2003 (the “Original Lease”), CMD Properties, Inc. (“Original Landlord”) leased to Tenant, and Tenant leased from Original
Landlord, approximately 11,021 rentable square feet of office space (the “Original Premises”) known as Suite 148 and Suite 144 in the building located at 2810 Meridian Parkway, Durham, North Carolina (the “Building”); 

B. Pursuant to that certain Lease Amendment One dated March 23, 2007 (the “First Amendment”), Original Landlord (now known
as Prince Properties, Inc.) and Tenant amended the Original Lease to extend the Term to April 30, 2013 upon the terms and conditions set forth in the First Amendment; 
 C. Landlord has purchased the Building from Original Landlord and succeeded to the interest of Original Landlord under the Original Lease,
as amended; and 
 D. Landlord and Tenant desire to amend the Original Lease, as amended, to provide for the demise to Tenant of
the Expansion Space (hereinafter defined), upon the terms and conditions set forth in this Second Amendment. 
 NOW,
THEREFORE, in consideration of the foregoing and for other good and valuable consideration and of the mutual agreements hereinafter set forth, it is hereby mutually agreed as follows: 
 1. Incorporation of Recitals. The foregoing recitals are hereby incorporated in this Second Amendment and made a part hereof by this
reference. 
 2. Definitions. All capitalized terms used in this Second Amendment shall have the meanings ascribed
thereto in the Original Lease, as amended, unless otherwise defined herein. As used herein and in the Original Lease, as amended: (a) the term “Lease” shall mean the Original Lease, as amended by the First Amendment and by this Second
Amendment; and (b) from and after the Expansion Space Commencement Date (hereinafter defined), the term “Premises” shall mean the Original Premises together with the Expansion Space. 
 3. Expansion Space. Subject to the terms and conditions set forth herein, Landlord hereby leases to Tenant, and Tenant hereby
leases from Landlord, for a term beginning on the Expansion Space Commencement Date and ending on the Expansion Space Expiration Date, approximately 5,293 rentable square feet of space in the Building, which is shown on the attached Exhibit A
(the “Expansion Space”). As of the Effective Date, the aggregate number of rentable square feet of space demised to Tenant under the Lease (consisting of the Original Premises and the Expansion Space) shall be 16,314. Notwithstanding any
provision to the contrary contained in the Lease, (i) Landlord hereby warrants and represents to Tenant that, as of the date of delivery of the Expansion Space to Tenant, the base Building systems serving the Expansion Space as of such date,
including HVAC, electrical, life safety, mechanical and plumbing systems (collectively, the “Base Building Systems”), shall be in good working order and condition, (ii) Landlord hereby warrants and represents, to the best of
Landlord’s knowledge, to Tenant that, as of the date of delivery of the Expansion Space to Tenant, the base Building is structurally sound and the Base Building Systems serving the Expansion Space are not in violation of any applicable Legal
Requirements (hereinafter defined), (iii) Landlord hereby warrants and represents to Tenant that, to the best of Landlord’s knowledge, as of the date of delivery of the Expansion Space to Tenant, the Expansion Space (specifically excluding
any Tenant Improvements (hereinafter defined) and any Expansion Space

 
HVAC System Work (hereinafter defined)) does not violate any applicable Legal Requirements; and (iv) provided that Tenant notifies Landlord in writing of any Latent Defects (hereinafter
defined) during the Expansion Space Term (hereinafter defined), Landlord (or, at Landlord’s sole option, Landlord’s contractor) shall remedy any such Latent Defect within thirty (30) days thereafter, provided, however, that, if the
remedy of any such Latent Defect is of a type and nature that would customarily take longer than thirty (30) days, then Landlord shall use commercially reasonable efforts to complete such remedy as soon as reasonably possible. As used herein,
the term “Latent Defects” shall mean any defects in the base Building or any of the Base Building Systems serving the Expansion Space as of the date of delivery of the Expansion Space to Tenant (but specifically excluding any Tenant
Improvements (hereinafter defined) and any Expansion Space HVAC System Work) that would not be apparent on a reasonable, non-invasive inspection of the Expansion Space by a qualified architect or engineer. In the event the base Building or the
Expansion Space is not structurally sound, the Expansion Space is in violation of any Legal Requirements or the Base Building Systems serving the Expansion Space are not in good working order and condition as of the date of delivery of the Expansion
Space, Landlord shall, upon receipt of written notice thereof from Tenant, use commercially reasonable efforts to remedy same as soon as reasonably possible (“Landlord’s Repair Work”), it being agreed that, to the extent the
completion of the Tenant Improvements with respect to the Expansion Space only and the completion of the Expansion Space HVAC System Work is delayed solely as a result of the performance of Landlord’s Repair Work in the Expansion Space, Tenant
shall not be deemed to be in default of Tenant’s obligation to timely complete the construction of the Tenant Improvements in the Expansion Space and the Expansion Space HVAC System Work, and the Expansion Space Rent Commencement Date
(hereinafter defined) shall be extended by one (1) day for each day of delay of the completion of the Tenant Improvements in the Expansion Space and the Expansion Space HVAC System Work caused solely as a result of the performance of
Landlord’s Repair Work in the Expansion Space. In the event Landlord performs any Landlord’s Repair Work in the Expansion Space, Landlord and Tenant hereby expressly acknowledge and agree that (a) Landlord shall use commercially
reasonable efforts to coordinate the performance of the Landlord’s Repair Work with Tenant’s construction of the Tenant Improvements and the Expansion Space HVAC System Work, (b) Landlord may perform the Landlord’s Repair Work
while Tenant and its contractors are constructing the Tenant Improvements and the Expansion Space HVAC System Work in the Expansion Space, (c) Landlord may be performing all or any portion of the Landlord’s Repair Work while Tenant is in
occupancy of the Expansion Space during normal business hours (i.e. Monday through Friday 9:00 a.m. to 5:00 p.m., excluding federal holidays) or other days or times selected by Landlord in its sole discretion; provided that Landlord shall not be
required to (but may in its sole discretion elect to) undertake any portion of Landlord’s Repair Work during days and times other than Monday through Friday, 9:00 a.m. to 5:00 p.m. (excluding federal holidays). Landlord shall not be responsible
for any inconvenience or interference with Tenant’s operations in the Expansion Space caused by, or in connection with, Landlord’s undertaking of Landlord’s Repair Work, and Tenant agrees that, except as otherwise expressly set forth
in this Paragraph 3, under no circumstances shall Landlord’s activities during or in connection with the undertaking of any such Landlord’s Repair Work be deemed to be, or construed as, a constructive eviction of Tenant or entitle Tenant
to any abatement of, or reduction in, any Rent due under the Lease. Tenant shall promptly comply with all of Landlord’s reasonable requests in connection with Landlord’s undertaking of the Landlord’s Repair Work, and Tenant shall use
reasonable efforts not to interfere with the undertaking of any such Landlord’s Repair Work. As used herein, the term “Landlord’s knowledge” shall mean the current, actual knowledge of Michael Gribbon, without any obligation to
investigate the facts underlying such representation and warranty. 
 4. Tenant Improvements; Early Occupancy of Expansion
Space; Removal of Tenant Improvements from the Expansion Space; Replacement of Existing Expansion Space HVAC System. 
 A.
Tenant Improvements. Tenant shall remain in possession of the Original Premises in its “as-is” condition without (i) any obligation on Landlord’s part, except for Landlord’s repair and maintenance obligations under
the Original Lease, to undertake any improvements or alterations in or to the Original Premises; or (ii) any obligation on Landlord’s part, except for the Improvement Allowance (as defined in the Work Agreement (hereinafter defined)) to be
provided by

  

					
		  	Page 2	  	

 
Landlord pursuant to the Work Agreement, pay for any improvements or alterations in or to the Original Premises; or (iii) any representations or warranties regarding the condition thereof.
Landlord shall deliver the Expansion Space to Tenant in its “as-is” condition without (a) any obligation on Landlord’s part, except for (1) any Landlord’s Repair Work and the cure of any Latent Defects, all in
accordance with the terms and provisions of Paragraph 3, above, and (2) Landlord’s repair and maintenance obligations under the Original Lease (except as otherwise expressly set forth in this Second Amendment), to undertake any
improvements or alterations in or to the Expansion Space; or (b) any obligation on Landlord’s part, except for the Improvement Allowance to be provided by Landlord pursuant to the Work Agreement, pay for any improvements or alterations in
or to the Expansion Space; or (c) except as otherwise specifically set forth in this Second Amendment, any representations or warranties regarding the condition thereof. Tenant shall, at Tenant’s sole cost and expense, subject to the
application of the Improvement Allowance, construct in the Premises the Tenant Improvements (as defined in the Work Agreement) described in the Work Agreement attached hereto as Exhibit B (the “Work Agreement”), in accordance with
the terms and conditions of the Work Agreement. The Tenant Improvements shall be subject to Landlord’s prior written approval in accordance with the terms of the Work Agreement attached hereto as Exhibit B and shall comply with all
applicable Legal Requirements. The cost of all design, architectural and engineering work, demolition costs, construction costs, construction supervision, contractors’ overhead and profit, licenses and permits, and all other costs and expenses
incurred in connection with the Tenant Improvements shall be at Tenant’s sole cost and expense, subject to the application of the Improvement Allowance. Landlord shall disburse the Improvement Allowance as provided in the Work Agreement. All
costs incurred with respect to the Tenant Improvements in excess of the Improvement Allowance shall be paid by Tenant as provided in the Work Agreement. Any portion of the Improvement Allowance not expended by Tenant in undertaking the Tenant
Improvements and the Expansion Space HVAC System Work within nineteen (19) months after the Effective Date shall be retained by Landlord and Tenant shall have no further right or claim to such retained portion of Improvement Allowance.

 B. Early Delivery of Expansion Space. Provided that Tenant has delivered to Landlord evidence reasonably satisfactory
to Landlord that all insurance required to be carried by Tenant and its contractor under the Lease is effective, Tenant shall have access to the Expansion Space immediately upon the occurrence of the Effective Date for purposes of commencing any
demolition work, as reasonably approved by Landlord in advance, in connection with construction of the Tenant Improvements and commencing the construction of the Tenant Improvements themselves; provided, however, Tenant shall not be entitled to make
any improvements to the Expansion Space, including without limitation commencing construction of the Tenant Improvements, until the Tenant’s Plans (as such term is defined in the Work Agreement) have been finally approved by Landlord in
accordance with the terms of the Work Agreement. Tenant shall be permitted to occupy the Expansion Space and conduct its business therein provided such occupancy is not in violation of any applicable Legal Requirements, it being agreed that, in the
event a certificate of occupancy or any other approvals are required for Tenant’s occupancy of the Expansion Space, or any portion thereof, or for purposes of conducting Tenant’s business in the Expansion Space, or any portion thereof,
from any governmental authorities having jurisdiction over the Expansion Space, Tenant shall not be permitted to occupy such portion of the Expansion Space or conduct its business in such portion of the Expansion Space unless and until Tenant
delivers to Landlord a certificate of occupancy or any other approvals required for such portion of the Expansion Space, all of which shall be obtained by Tenant at Tenant’s sole cost and expense. All terms and conditions of the Lease shall
apply to and be effective during such period of occupancy by Tenant of the Expansion Space prior to the Expansion Space Commencement Date, except for Tenant’s obligation to pay Rent. Notwithstanding the foregoing, except as otherwise expressly
set forth in this Second Amendment, no delay by Tenant in completing the Tenant Improvements or obtaining a certificate of occupancy or any other governmental permits or approvals required for Tenant’s occupancy of the Expansion Space shall
delay or otherwise affect the Expansion Space Commencement Date or the Expansion Space Rent Commencement Date. 
 C. No
Expansion Space Base Rent or Expansion Space Additional Rent During Early Occupancy of Expansion Space. With respect to the Expansion Space only, Tenant shall have no obligation to pay Landlord Expansion Space Annual Base Rent (hereinafter
defined) or Tenant’s Expansion Space Share (hereinafter defined) of Taxes, Insurance and Expenses (each as defined in the Original Lease) during the period that is before the Expansion Space Commencement Date. 
  

					
		  	Page 3	  	

 D. Removal of Tenant Improvements from the Expansion Space. Notwithstanding any
contrary provision contained in the Lease, Landlord and Tenant hereby acknowledge and agree that, unless otherwise agreed to in writing by Landlord, Tenant, at Tenant’s sole cost and expense, shall remove from the Expansion Space, on or before
the expiration or earlier termination of the Lease, all modular clean room hard and soft walls and ceilings constructed in the Expansion Space as part of the Tenant Improvements and approved by Landlord pursuant to the Work Agreement, including the
repair of any and all damage to the Expansion Space caused by such removal, and otherwise vacate and surrender the Expansion Space in broom clean, “shell” condition, ordinary wear and tear excepted, it being agreed by the parties hereto
that Tenant shall leave intact all modular flooring, all non-modular walls, floors and ceilings and all electrical and lighting systems and improvements that remain after the removal of such modular clean room walls and ceilings (collectively, the
“Removal Work”). The Removal Work shall be performed in a manner reasonably acceptable to Landlord and, except as otherwise set forth in this Paragraph 4.D, in strict accordance with the terms and conditions of the Original Lease,
including but not limited to the terms and conditions of Article 9 thereof (captioned, “Alterations and Liens”) and Article 23 thereof (captioned, “Return of Possession”); provided, however, that in no event shall Tenant remove,
or have the right to remove, the Expansion Space HVAC Units (hereinafter defined). Under no circumstances shall Tenant’s activities during or in connection with the performance of the Removal Work be deemed to be, or construed as, a
constructive eviction of Tenant or entitle Tenant to any abatement of, or reduction in, Rent due under the Lease. 
 E.
Replacement of Existing Expansion Space HVAC System. Subject to the terms and conditions set forth below, Tenant shall, at Tenant’s sole cost and expense, subject to application of the Improvement Allowance, replace the HVAC system,
including any related HVAC units, currently serving the Expansion Space (the “Existing Expansion Space HVAC System”) and install, in lieu thereof, the Expansion Space HVAC System (hereinafter defined). As used herein, the term
“Expansion Space HVAC System” shall mean a heating and air conditioning system designed to exclusively serve the Expansion Space, including any related heating and air conditioning units (the “Expansion Space HVAC Units”), having
specifications, size, capacity, components and other characteristics (collectively, the “Expansion Space HVAC System Characteristics”) approved by Landlord in its reasonable discretion. Landlord and Tenant hereby acknowledge and agree
that, as of the Effective Date hereof, Tenant has provided to Landlord, and Landlord has approved, those certain preliminary plans and specifications for the installation of the Expansion Space HVAC System (the “Expansion Space HVAC System
Preliminary Plans”), a true and complete copy of which is attached hereto as Exhibit C and made a part hereof, which Expansion Space HVAC System Preliminary Plans include, inter alia, (i) the locations of the Expansion Space HVAC
Units on the Building’s roof (the “Roof”), (ii) the Expansion Space HVAC System Characteristics, and (iii) preliminary details showing all aesthetic, structural, mechanical, plumbing and electrical work with respect to the
installation of the Expansion Space HVAC System, including all associated cabling, conduit, ductwork, piping, wiring and other equipment relating thereto, and all changes to the Building which are necessary to accommodate same. Promptly after the
Effective Date hereof, Tenant shall submit to Landlord for Landlord’s approval, such approval not to be unreasonably withheld, conditioned or delayed, final plans and specifications for the installation of the Expansion Space HVAC System (the
“Expansion Space HVAC System Final Plans”) complying with those conditions and requirements set forth in Schedule B-2 attached to the Work Agreement, below, to be prepared by qualified engineers, and showing all aesthetic,
structural, mechanical, plumbing and electrical details of the Expansion Space HVAC System, as well as all associated cabling, conduit, ductwork, piping, wiring and other equipment relating thereto, and all changes to the Building which are
necessary to accommodate same, all in accordance with all applicable Legal Requirements; provided, however, that (a) in the event the Expansion Space HVAC System Final Plans contain no changes whatsoever from the Expansion Space HVAC System
Preliminary Plans, Landlord and Tenant hereby acknowledge and agree that the Expansion Space HVAC System Final Plans shall be deemed approved by Landlord, provided Landlord has had an opportunity to review and confirm in writing to Tenant that the
Expansion Space HVAC System Final Plans contain no such changes, (b) in the event the Expansion Space HVAC System

  

					
		  	Page 4	  	

 
Final Plans contain any material changes, Landlord shall have the right to disapprove of any such material change in its sole discretion, acting in good faith. For purposes of this Paragraph 4.E
only, a “material” change shall be any change to the Expansion Space HVAC System Preliminary Plans reflected in the Expansion Space HVAC System Final Plans that (v) will affect the exterior or structure of the Building or materially
or adversely affect any Base Building Systems, (w) will relocate any Expansion Space HVAC Unit to another location on the Roof, (x) may damage the structural integrity of the Building, (y) may void any warranty or guaranty applicable
to the Roof or the Building, or (z) may cause the violation of any zoning ordinance or other governmental or quasi-governmental law, rule or regulation applicable to the Building. Notwithstanding any contrary provision contained in this Second
Amendment, Landlord and Tenant hereby acknowledge and agree that the Expansion Space HVAC System Preliminary Plans attached hereto as Exhibit C have been approved by Landlord, as of the Effective Date hereof, as the Expansion Space HVAC System Final
Plans. Tenant shall coordinate the removal of the Existing Expansion Space HVAC System and the installation of the Expansion Space HVAC System with Landlord and use commercially reasonable efforts to minimize disruption to any other tenants,
licensees or other occupants of the Building, provided that Landlord and Tenant expressly acknowledge and agree that the removal of the Existing Expansion Space HVAC System and the installation of the Expansion Space HVAC System (the “Expansion
Space HVAC System Work”) shall be undertaken by Tenant during business hours, Monday – Friday (excluding holidays). Tenant, at Tenant’s sole cost and expense, shall retain the services of a contractor licensed in the State of North
Carolina and otherwise reasonably approved in advance in writing by Landlord, to perform the removal of the Existing Expansion Space HVAC System and the installation of the Expansion Space HVAC System. Prior to the installation of the Expansion
Space HVAC System by Tenant: (1) Tenant shall obtain all permits and governmental approvals required for the installation of the Expansion Space HVAC System; and (2) Tenant and the contractor approved by Landlord to undertake such
installation shall comply with those conditions and requirements set forth in Paragraph D.2 of the Work Agreement, below, including obtaining such insurance coverages as set forth therein and naming Landlord as an additional insured thereunder.
Landlord may require as a precondition to its approval of the installation of the Expansion Space HVAC System that Tenant (or, at Landlord’s option, Landlord), at Tenant’s sole cost and expense, install additional structural support (in a
manner determined by Landlord’s engineer in its reasonable discretion) to those portions of the Roof and/or the Building on which Tenant desires to install the Expansion Space HVAC Units. Tenant shall not be entitled to rely on any such
approval as being a representation by Landlord that such installation and operation is permitted by or in accordance with any zoning ordinance or other governmental or quasi-governmental law, rule or regulation applicable to the Building. Landlord
shall have the right to inspect the Expansion Space HVAC System to determine, inter alia, if the Expansion Space HVAC System is causing damage to the Roof or any other part of the Building and/or to repair the Roof or remove or relocate any
components of the Expansion Space HVAC System. Throughout the Expansion Space Term, Tenant shall (A) cause the Expansion Space HVAC System to comply with all applicable Legal Requirements; (B) maintain the Expansion Space HVAC System in
good order and repair, including replacement thereof; (C) maintain insurance coverages with respect thereto as are required by Landlord from time to time; and (D) maintain all permits and governmental approvals necessary for the operation
of the Expansion Space HVAC System. Except to the extent caused by the gross negligence or willful misconduct of Landlord, its agents or employees, Tenant shall indemnify Landlord and hold it harmless from and against all claims, liability, damage
or costs, including reasonable attorneys’ fees, suffered or sustained by Landlord which arise out of the installation, use, operation, removal or existence of the Expansion Space HVAC System. Tenant expressly acknowledges and agrees that,
notwithstanding the fact that Landlord has permitted Tenant to install the Expansion Space HVAC System, Tenant shall remain liable under this Paragraph 4.E for all claims, damages, costs or liabilities suffered or sustained by Landlord which arise
out of the presence of Hazardous Materials which were brought on the Property or into the Building by Tenant, its employees, agents, contractors, licensees or invitees. 
 5. Expansion Space Term. The Term with respect to the Expansion Space (the “Expansion Space Term”) shall commence on January 1, 2009 (the “Expansion Space Commencement
Date”) and shall expire on December 31, 2013 (the “Expansion Space Expiration Date”), unless extended or earlier terminated in accordance with the terms and provisions of the Lease. Reference is made to the

  

					
		  	Page 5	  	

 
form of Declaration of Expansion Space Commencement Date (the “Declaration”) attached hereto as Exhibit D. After the Expansion Space Rent Commencement Date, Landlord shall
complete the Declaration and deliver the completed Declaration to Tenant. Within five (5) business days after Tenant receives the completed Declaration from Landlord, Tenant shall execute and return the Declaration to Landlord to confirm the
Expansion Space Commencement Date, and the Expansion Space Rent Commencement Date. Failure to execute the Declaration shall not affect the commencement or expiration of the Expansion Space Term. 
 6. Expansion Space Base Rent. Commencing on April 1, 2009 (the “Expansion Space Rent Commencement Date”), and
thereafter on the first day of each and every calendar month during the Expansion Space Term, Tenant shall pay Landlord Base Rent for the Expansion Space only (“Expansion Space Annual Base Rent”) in the following amounts, in equal monthly
installments (“Expansion Space Monthly Base Rent”), in advance, as follows: 
  

											
	Period	  	 Expansion Space            
 Annual Base Rent            
 Per
Rentable            
 Square
Foot            
	  	 Expansion Space          
 Annual
Base          
 Rent          
	 	 	 Expansion            
 Space Monthly            
 Base
Rent            

	 4/1/09 – 12/31/09
	  	$	12.00	  	$	63,516.00	* 	 	$	5,293.00
	 1/1/10 – 12/31/10
	  	$	12.36	  	$	65,421.48	  	 	$	5,451.79
	 1/1/11 – 12/31/11
	  	$	12.73	  	$	67,379.89	  	 	$	5,614.99
	 1/1/12 – 12/31/12
	  	$	13.11	  	$	69,401.29	  	 	$	5,783.44
	 1/1/13 – 12/31/13
	  	$	13.51	  	$	71,483.33	  	 	$	5,956.94
	[*on an annualized basis]

 Tenant shall pay Landlord Expansion Space Annual Base Rent in accordance with the terms and
conditions of Article 3 of the Original Lease (captioned, “Base Rent and Additional Rent”). 
 7. Additional Rent
for Expansion Space. 
 A. Taxes, Insurance and Expenses. Commencing on the Expansion Space Rent Commencement Date
and continuing throughout the Expansion Space Term, Tenant shall pay Landlord Tenant’s Expansion Space Share of all Taxes, Insurance and Expenses, in accordance with the terms and conditions of the Original Lease, as modified hereby. As used
herein the term “Tenant’s Expansion Space Share” means 5.25%. 
 B. Utilities and Services. In accordance
with the terms and conditions of Article 6 of the Original Lease, Tenant shall obtain in Tenant’s own name and pay the utility company or other provider directly for all utilities and services furnished to or for the Expansion Space.

 8. Tenant’s Continuing Obligations with Respect to the Original Premises. Between the Effective Date and New
Expiration Date (defined in the First Amendment as April 30, 2013), Tenant shall continue to pay to Landlord (i) all Base Rent for the Original Premises in accordance with the terms and conditions of Article 3 of the Original Lease and
(ii) Tenant’s Share of Taxes, Insurance and Expenses with respect to the Original Premises in accordance with the terms and conditions of Article 3 of the Original Lease. 
 9. Additional Modification. As of the Expansion Space Commencement Date, with respect to exclusions to
“Expenses” set forth in Article 30(C) of the Original Lease, the second (2nd) sentence therein is hereby amended by inserting at the end thereof the following: 
 “(3) management fees exceeding four percent (4%) of Landlord’s gross revenues with respect to the Building; and 
  

					
		  	Page 6	  	

 (4) Landlord’s general overhead and general administrative expenses, other than charges
for property management and in-house labor provided for maintenance of the Building or the Property.” 
 10. Brokers.
Landlord and Tenant recognize ACP Mid-Atlantic LLC, as Landlord’s agent, and Colliers Pinkard, as Tenant’s agent, as the sole brokers (collectively, the “Brokers”) with respect to this Second Amendment. Landlord and Tenant
represent and warrant each to the other that they have not dealt with any broker(s) or any other person claiming any entitlement to any commission in connection with this transaction except for the Brokers. Tenant agrees to indemnify and save
Landlord and Landlord’s management agent harmless from and against any and all claims, suits, liabilities, costs, judgments and expenses, including reasonable attorneys’ fees, for any leasing commissions or other commissions, fees, charges
or payments resulting from or arising out of its respective actions in connection with this Second Amendment. Landlord agrees to indemnify and save Tenant harmless from and against any and all claims, suits, liabilities, costs, judgments and
expenses, including reasonable attorneys’ fees, for any leasing commissions or other commissions, fees, charges or payments resulting from or arising out of its actions in connection with this Second Amendment. Landlord agrees to be responsible
for the leasing commission due the Brokers pursuant to separate written agreements between Landlord and each of the Brokers, and to hold Tenant harmless respecting same. 
 11. Landlord’s Notice Address. Landlord’s Notice Address, as set other in Article 1.M of the Original Lease and as amended by Section 7 of the First Amendment, is amended by
inserting the following as Landlord’s address for notices under the Lease: 
  

					
	“Landlord’s Notice Address:	 		  	 ACP 2810 Meridian LLC
 Attn:
Chief Operating Officer
 444 Brickell Avenue
 Suite 900
 Miami, Florida 33131
  
 With copies to:
  
 ACP 2810 Meridian LLC
 c/o ACP Mid-Atlantic LLC, as Agent
 Attn: Asset Manager
 2350 Corporate Park
Drive
 Suite 110
 Herndon, Virginia
20171
  
 and
  
 Holland & Knight LLP
 2099 Pennsylvania Avenue, NW
 Suite 100

Washington, DC 20006
 Attn: David S. Kahn,
Esq.”

 12. USA Patriot Act and Anti-Terrorism Laws. As of the Effective Date, the
Original Lease is hereby amended by adding the following language as new Article 34 thereof: 
 “ARTICLE 34: USA PATRIOT
ACT AND ANTI-TERRORISM LAWS 
 (a) Tenant represents and warrants, to the best of Tenant’s knowledge,
to, and covenants with, Landlord that neither Tenant nor any of its respective constituent owners or affiliates currently are, or shall be at any time during the Term hereof, in violation of any laws relating to terrorism or money laundering
(collectively, the “Anti-Terrorism Laws”), including without limitation Executive Order No. 13224 on Terrorist Financing, effective September 24, 2001 and relating to Blocking Property and

  

					
		  	Page 7	  	

 
Prohibiting Transactions With Persons Who Commit, Threaten to Commit, or Support Terrorism (the “Executive Order”) and/or the Uniting and Strengthening America by Providing Appropriate
Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Public Law 107-56) (the “USA Patriot Act”). 
 (b) Tenant covenants with Landlord that neither Tenant nor any of its respective constituent owners or affiliates is or shall be during the Term hereof a “Prohibited Person,” which is defined as follows: (i) a person or
entity that is listed in the Annex to, or is otherwise subject to, the provisions of the Executive Order; (ii) a person or entity owned or controlled by, or acting for or on behalf of, any person or entity that is listed in the Annex to, or is
otherwise subject to the provisions of, the Executive Order; (iii) a person or entity with whom Landlord is prohibited from dealing with or otherwise engaging in any transaction by any Anti-Terrorism Law, including without limitation the
Executive Order and the USA Patriot Act; (iv) a person or entity who commits, threatens or conspires to commit or support “terrorism” as defined in Section 3(d) of the Executive Order; (v) a person or entity that is named as
a “specially designated national and blocked person” on the then-most current list published by the U.S. Treasury Department Office of Foreign Assets Control at its official website,
http://www.treas.gov/offices/eotffc/ofac/sdn/t11sdn.pdf, or at any replacement website or other replacement official publication of such list; and (vi) a person or entity who is affiliated with a person or entity listed in items
(i) through (v), above. 
 (c) At any time and from time-to-time during the Term of the Lease, Tenant shall
deliver to Landlord, within ten (10) days after receipt of a written request therefor, a written certification or such other evidence reasonably acceptable to Landlord evidencing and confirming Tenant’s compliance with this Article
34.” 
 13. Counterpart Copies. This Second Amendment may be executed in two (2) or more counterpart copies,
all of which counterparts shall have the same force and effect as if all parties hereto had executed a single copy of this Second Amendment. 
 14. Miscellaneous. This Second Amendment (A) shall be binding upon and inure to the benefit of the parties hereto and their respective representatives, transferees, successors and assigns and
(B) shall be governed by and construed in accordance with the laws of the State of North Carolina. 
 15.
Ratification. Except as expressly amended by this Second Amendment, all other terms, conditions and provisions of the Lease are hereby ratified and confirmed and shall continue in full force and effect, including, without limitation,
Tenant’s rights to assign the Lease or sublet the Expansion Space in accordance with terms and provisions set forth in Article 13 of the Original Lease (captioned, “Assignment and Subletting”). 
 [signatures appear on the following page] 
  

					
		  	Page 8	  	

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment to Lease
Agreement under seal as of the day and year first hereinabove written. 
  

					
	LANDLORD:
	
	 ACP 2810 MERIDIAN LLC,
 a Delaware limited liability company

		
	By:	 	 /s/ Illegible

		 	Name:	 	
		 	Title:	 	Manager
	
	TENANT:
	
	 ALDAGEN, INC.,
 a Delaware corporation

		
	By:	 	 /s/ Edward Field

		 	Name:	 	Edward Field
		 	Title:	 	President

  

					
		  	Page 9	  	

 EXHIBIT A 
 FLOOR PLAN OF EXPANSION SPACE 
 [diagram omitted]

 EXHIBIT B 
 WORK AGREEMENT 
 This Work Agreement (the “Work
Agreement”) is attached to and made a part of that certain Second Amendment to Lease Agreement (the “Second Amendment”) dated
                    , 2008 by and between ACP 2810 MERIDIAN, LLC, as landlord (“Landlord”), and ALDAGEN, INC., as tenant
(“Tenant”), for the premises (the “Premises”) described therein (consisting of the Original Premises and the Expansion Space) in the building having a street address of 2810 Meridian Parkway, Durham, North Carolina (the
“Building”). It is the intent of this Work Agreement that Tenant shall be permitted freedom in the design and layout of the Original Premises and Expansion Space, consistent with applicable building codes and requirements of law, including
without limitation the Americans with Disabilities Act, and with sound architectural and construction practice in comparable one-story flex space buildings, provided that neither the design nor the implementation of the Tenant Improvements
(hereinafter defined) shall, except as otherwise approved by Landlord in accordance with this Work Agreement, cause any material and/or adverse interference to the operation of any Base Building Systems or to other Building operations or functions,
nor shall they increase maintenance or utility charges for operating the Building. Capitalized terms not otherwise defined in this Work Agreement shall have the meanings set forth in the Second Amendment. In the event of any conflict between the
terms hereof and the terms of the Second Amendment, the terms hereof shall prevail for the purposes of design and construction of the Tenant Improvements. 
 A. TENANT IMPROVEMENTS. 
 1. As-Is Condition. Except for
Landlord’s repair and maintenance obligations under the Original Lease, Landlord shall have no obligation to perform or cause the performance or construction of any improvements in or to the Original Premises and Tenant shall remain in
possession of the Original Premises in its “as-is” condition. Except for Landlord’s Repair Work, if any, and the cure of any Latent Defects, both with respect to the Expansion Space only, Landlord shall have no obligation to perform
or cause the performance or construction of any improvements in or to the Expansion Space and Landlord shall deliver the Expansion Space to Tenant in its “as is” condition. Tenant hereby acknowledges that, except as otherwise specifically
set forth in this Second Amendment, Landlord has made no representations or warranties to Tenant with respect to the condition of the Original Premises or the Expansion Space or the working order of any systems or improvements therein. 

2. Tenant Improvements. Tenant, at its sole cost and expense, shall furnish and install in the Premises (consisting of the
Original Premises and the Expansion Space, as applicable), in accordance with the terms of this Work Agreement, the improvements set forth in the Tenant’s Plans (hereinafter defined) which are subject to Landlord’s approval in accordance
with Paragraph B.3, below (the “Tenant Improvements”). All costs of all design, space planning, and architectural and engineering work for or in connection with the Tenant Improvements, including without limitation all drawings, plans,
specifications, licenses, permits or other approvals relating thereto, and all insurance and other requirements and conditions hereunder, and all costs of construction, excluding Landlord’s supervision thereof, shall be at Tenant’s sole
cost and expense, subject to the application of the Improvement Allowance in accordance with the terms of this Work Agreement. 
 B. PLANS AND SPECIFICATIONS. 
 1. Space Planner. Tenant shall retain the services of a space planner
reasonably approved by Landlord (the “Space Planner”) to design those certain Tenant Improvements to be located in, or for the benefit of, the Original Premises (the “Original Premises Tenant Improvements”), if any, and those
certain Tenant Improvements to be located in, or for the benefit of, the Expansion Space (the “Expansion Space Tenant Improvements”) and prepare the Original Premises Proposed Space Plan (hereinafter defined), if applicable, the Expansion
Space Final Space Plan (hereinafter defined), the Original Premises Contract Documents (hereinafter defined), if applicable, and the Expansion Space Contract Documents (hereinafter defined). The Space Planner shall meet with the Landlord and/or
Landlord’s building manager from time to time to obtain information about the Building and to insure

  

					
		 	Exhibit B	 	

 
that the improvements envisioned in the Original Premises Contract Documents, if applicable, and the Expansion Space Contract Documents do not, except as otherwise approved by Landlord in
accordance with this Work Agreement, interfere with and/or affect the Building or any systems therein. The Space Planner shall prepare all space plans, working drawings, and plans and specifications described in Paragraph B.3, below, and the Space
Planner shall coordinate its plans and specifications with the Engineers (hereinafter defined) and Landlord. All fees of the Space Planner shall be borne solely by Tenant, subject to application of the Improvement Allowance as hereinafter provided.

 2. Engineers. Tenant shall retain the services of mechanical, electrical, plumbing and structural engineers reasonably
approved by Landlord (the “Engineers”) to (a) design the type, number and location of all mechanical systems in the Original Premises, if applicable, and the Expansion Space, including without limitation the heating, ventilating and
air conditioning system therein, fire alarm system and to prepare all of the mechanical plans, (b) to assist Tenant and the Space Planner in connection with the electrical design of the Original Premises, if applicable, and the Expansion Space,
including the location and capacity of light fixtures, electrical receptacles and other electrical elements, and to prepare all of the electrical plans, (c) to assist Tenant and the Space Planner in connection with plumbing-related issues
involved in designing the Original Premises, if applicable, and the Expansion Space and to prepare all of the plumbing plans, and (d) assist Tenant and the Space Planner in connection with the structural elements of the Space Planner’s
design of the Original Premises, if applicable, and the Expansion Space and to prepare all of the structural plans. All fees of the Engineers shall be borne solely by Tenant, subject to application of the Improvement Allowance as hereinafter
provided. 
 3. Time Schedule. 
 a. (i) As of the Effective Date, Tenant has furnished to Landlord, and Landlord has approved, those certain preliminary plans and specifications for the construction of the Expansion Space Tenant
Improvements (the “Expansion Space Final Space Plan”), a true and complete copy of which is attached hereto as Exhibit B-1 and made a part hereof, which Expansion Space Final Space Plan includes, inter alia, (1) the locations
and layout of all “minor” or “light” laboratory space (i.e., clean labs) to be included as part of the Expansion Space Tenant Improvements, and (2) preliminary details and specifications showing all aesthetic, structural,
mechanical, plumbing and electrical work with respect to the construction of the Expansion Space Tenant Improvements, including all core drilling, cabling, conduit, ductwork, piping, wiring and other equipment related thereto, and all changes to the
Building and Base Building Systems which are necessary to accommodate same. 
 (ii) After the Effective Date, to the extent
Tenant desires to undertake any Original Premises Tenant Improvements in the Original Premises, Tenant shall furnish to Landlord for its review and approval a proposed detailed space plan for the Original Premises Tenant Improvements (the
“Original Premises Proposed Space Plan”) prepared by the Space Planner. The Original Premises Proposed Space Plan, if applicable, shall include the information and the requirements therefor described in Schedule B-1 attached hereto
(the “Original Premises Proposed Space Plan Requirements”). If submitted by Tenant, Landlord shall advise Tenant of Landlord’s approval or disapproval of the Original Premises Proposed Space Plan within five (5) business days
after receipt thereof. If Landlord disapproves of the Original Premises Proposed Space Plan (or any portion thereof), Tenant shall promptly revise the Original Premises Proposed Space Plan to meet Landlord’s objections, if any, and resubmit the
Original Premises Proposed Space Plan to Landlord for its review and approval within five (5) business days of Tenant’s receipt of Landlord’s objections, if any, and such process shall continue until Landlord has approved the Original
Premises Proposed Space Plan (the “Original Premises Final Space Plan,” and, together with the Expansion Space Final Space Plan, the “Final Space Plans”). Subject to Paragraph B.3.d, below, Landlord’s approval of the
Original Premises Final Space Plan shall not be unreasonably withheld, conditioned or delayed. 
 b. Promptly after the
Effective Date, Tenant shall furnish to Landlord for its review and approval, all final architectural plans, working drawings and specifications (the “Expansion Space Contract Documents”) necessary and sufficient (i) for the
construction of the Expansion Space Tenant Improvements; and (ii) to enable Tenant to obtain a building permit for the construction of the

  

					
		 	Exhibit B, Page 2	 	

 
Expansion Space Tenant Improvements by the Contractor (hereinafter defined). To the extent Tenant desires to undertake any Original Premises Tenant Improvements in the Original Premises, after
Landlord has approved the Original Premises Final Space Plan, Tenant shall furnish to Landlord for its review and approval, all final architectural plans, working drawings and specifications (the “Original Premises Contract Documents,”
and, together with the Expansion Space Contract Documents, the “Contract Documents”) necessary and sufficient (1) for the construction of the Original Premises Tenant Improvements; and (2) to enable Tenant to obtain a building
permit for the construction of the Original Premises Tenant Improvements by the Contractor. All Contract Documents shall contain the information and otherwise comply with the requirements therefore described in Schedule B-2 attached hereto
and shall set forth the location of any core drilling by Tenant (the approval of same shall be subject to Landlord’s approval in its sole discretion). Landlord shall advise Tenant of Landlord’s approval or disapproval of any Contract
Documents within five (5) business days after Tenant submits such Contract Documents to Landlord. If Landlord disapproves of any Contract Documents (or any portion thereof), Tenant shall promptly revise such Contract Documents to meet
Landlord’s objections, if any, and resubmit such Contract Documents to Landlord for its review and approval within five (5) business days of Tenant’s receipt of Landlord’s objections, if any. Landlord shall advise Tenant of
Landlord’s approval or disapproval of such revised Contract Documents within five (5) business days after Tenant submits same, and such process shall continue until Landlord has approved such Contract Documents. Notwithstanding anything
herein to the contrary, approval by Landlord of any Contract Documents shall not constitute an assurance by Landlord that such Contract Documents: (a) satisfy Legal Requirements (hereinafter defined), (b) are sufficient to enable Tenant to
obtain a building permit for the undertaking of the Tenant Improvements in the Original Premises or the Expansion Space, as applicable, or (c) will not interfere with, and/or otherwise affect, base Building or Base Building Systems. Subject to
Paragraph B.3.d, below, Landlord’s approval of any Contract Documents shall not be unreasonably withheld, conditioned or delayed. Notwithstanding any contrary provision contained in this Work Agreement or the Second Amendment, Landlord and
Tenant hereby acknowledge and agree that the Expansion Space Final Space Plan attached hereto as Exhibit B-1 has been approved by Landlord, as of the Effective Date hereof, as the Expansion Space Contract Documents. 
 c. The Original Premises Final Space Plan, if any, the Expansion Space Final Space Plan, the Original Premises Contract Documents, if any,
and the Expansion Space Contract Documents are referred to collectively herein as the “Tenant’s Plans.” 
 d. The Tenant Improvements shall be of first-class quality, using new materials, and commensurate with the level of improvements set forth in Tenant’s Plans approved by Landlord. The Tenant’s
Plans shall be prepared in accordance with a Data Cadd or convertible DXF format for working drawings (using  1/8” reproducible drawings) in conformity with the base Building plans and Base Building Systems and with information furnished by and in coordination with Landlord and Engineers.
Tenant’s Plans shall comply with all applicable building codes, laws and regulations (including without limitation the Americans with Disabilities Act), shall not contain any improvements which, except as otherwise approved by Landlord in
accordance with this Work Agreement, materially and adversely interfere with or require any material changes to or modifications of the Base Building Systems or to other Building operations or functions, and, unless Tenant agrees in writing to pay
all such excess costs or charges, shall not increase maintenance or utility charges for operating the Building in excess of the standard requirements for comparable one-story flex space buildings in the Raleigh/Durham, North Carolina area. Except as
otherwise expressly set forth in this Work Agreement, Landlord’s approval of any Contract Documents shall not be unreasonably withheld, conditioned or delayed; provided, however, that Landlord shall have the right to disapprove, in its sole
discretion, acting in good faith, any portion of any Contract Documents that Landlord believes, acting in good faith, will affect the exterior or structure of the Building or will materially and adversely affect any Base Building Systems.
Notwithstanding any contrary provision contained in this Work Agreement, (i) in the event the Expansion Space Contract Documents contain no changes whatsoever from the Expansion Space Final Space Plan, Landlord and Tenant hereby acknowledge and
agree that the Expansion Space Contract Documents shall be deemed approved by Landlord, provided Landlord has had an opportunity to review and confirm in writing to Tenant that the Expansion Space Contract Documents contain no such changes, and
(ii) in the 

  

					
		 	Exhibit B, Page 3	 	

 
event the Expansion Space Contract Documents contain any material changes, Landlord shall have the right to disapprove of any such material change in its sole discretion, acting in good faith.
For purposes of this Paragraph B.3.d only, with respect to Landlord’s review and approval of the Expansion Space Contract Documents only, a “material” change shall be any change to the Expansion Space Final Space Plan reflected in the
Expansion Space Contract Documents that (A) will affect the exterior or structure of the Building or materially or adversely affect any Base Building Systems, (B) may damage the structural integrity of the Building, (C) may void any
warranty or guaranty applicable to the Roof or the Building, or (D) may cause the violation of any zoning ordinance or other governmental or quasi-governmental law, rule or regulation applicable to the Building. 
 e. If Landlord fails to timely approve or disapprove of any Expansion Space Contract Documents within five (5) business days after
Tenant submits same to Landlord, and thereafter Tenant delivers a written notice (“Response Failure Notice”) to Landlord stating that Landlord has failed to timely respond to Tenant’s request for approval of any Expansion Space
Contract Documents, which Response Failure Notice must refer to this provision and state in capital bold letters in the Response Failure Notice and on the outside of the envelope containing the Response Failure Notice the following:
“LANDLORD MUST RESPOND TO TENANT’S REQUEST CONTAINED HEREIN WITHIN FIVE (5) BUSINESS DAYS OF RECEIPT OR THE EXPANSION SPACE RENT COMMENCEMENT DATE MAY BE EXTENDED,” and Landlord fails to respond to Tenant’s request
for approval of the Expansion Space Contract Documents within five (5) business days after Landlord’s receipt of the Response Failure Notice, then the Expansion Space Rent Commencement Date shall be extended one (1) day for each day
after the foregoing five (5) business day period that Landlord fails to respond to a Response Failure Notice. 
 4. Base
Building Changes. If (a) Tenant requests work to be done in the Original Premises or the Expansion Space or for the benefit of the Original Premises or the Expansion Space that necessitates revisions or changes in the design or construction
of the base Building or materially and adversely affects any of the Base Building Systems, and (b) such work was not reflected in Tenant’s Plans or has not otherwise been approved by Landlord in writing, any such changes shall be subject
to the prior written approval of Landlord, such approval not to be unreasonably withheld, conditioned or delayed; provided, however, that, in the event there are any material changes to Tenant’s Plans, Landlord shall have the right to
disapprove of any such material change in its sole discretion, acting in good faith. For purposes of this Paragraph B.4 only, a “material” change shall be any change to the Tenant’s Plans that (i) will affect the exterior or
structure of the Building or materially or adversely affect any Base Building Systems, (ii) may damage the structural integrity of the Building, (iii) may void any warranty or guaranty applicable to the Roof or the Building, or
(iv) may cause the violation of any zoning ordinance or other governmental or quasi-governmental law, rule or regulation applicable to the Building. Tenant shall be responsible for all costs and delays resulting from such design revisions or
construction changes, including architectural and engineering charges, and any special permits or fees attributed thereto. 
 5. Changes. 
 a. In the event that Tenant requests any changes to any Contract Documents or any Final Space
Plan after Landlord has approved same, or if it is determined that any Contract Documents prepared in accordance with the applicable Final Space Plan do not conform to the plans for the base Building, deviate from applicable Legal Requirements or
contain improvements which will or may interfere with and/or affect the base Building or any of the Base Building Systems, or in the event of any change orders, Tenant shall be responsible for all costs and expenses and all delay resulting
therefrom, including without limitation costs or expenses relating to (i) any additional architectural or engineering services and related design expenses, (ii) any changes to materials in process of fabrication, (iii) cancellation or
modification of supply or fabricating contracts, (iv) removal or alteration of work or plans completed or in process, or (v) delay claims made by any subcontractor. 
 b. No changes shall be made to any Contract Documents without the prior written approval of Landlord, which approval shall not be
unreasonably withheld, conditioned or delayed; provided, however, that, in the event there are any material changes to any Contract Documents, Landlord

  

					
		 	Exhibit B, Page 4	 	

 
shall have the right to disapprove of any such material change in its sole discretion, acting in good faith. For purposes of this Paragraph B.5.b only, a “material” change shall be any
change to any Contract Documents that (i) will affect the exterior or structure of the Building or materially or adversely affect any Base Building Systems, (ii) may damage the structural integrity of the Building, (iii) may void any
warranty or guaranty applicable to the Roof or the Building, or (iv) may cause the violation of any zoning ordinance or other governmental or quasi-governmental law, rule or regulation applicable to the Building. Tenant shall be responsible for
all costs and delays resulting from such design revisions or construction changes, including architectural and engineering charges, and any special permits or fees attributed thereto. Landlord shall not be responsible for delay in occupancy by
Tenant because of any changes to any Final Space Plan or any Contract Documents after approval by Landlord, or because of delay caused by or attributable to any deviation by any Contract Documents from applicable Legal Requirements. As used herein,
the term “Legal Requirements” shall mean any laws, ordinances, codes, regulations and orders of the United States of America, the State of North Carolina and any other governmental authority with jurisdiction over the Building, the
construction of the Tenant Improvements or the performance of the Expansion Space HVAC System Work, including, without limitation, the Americans with Disabilities Act. 
 6. Landlord Delay. In the event Landlord fails to approve or disapprove Tenant’s proposed Expansion Space Contract Documents or proposed Expansion Space HVAC System Final Plans within five
(5) business days after Tenant submits same to Landlord, Tenant shall resubmit same to Tenant, and Landlord shall advise Tenant of Landlord’s approval or disapproval thereof within five (5) business days after Tenant resubmits same to
Landlord. In the event the completion of the Expansion Space Tenant Improvements or the completion of the Expansion Space HVAC System Work is delayed solely by Landlord’s failure to respond to Tenant within such additional five
(5) business day period to any resubmission by Tenant of Tenant’s proposed Expansion Space Contract Documents or proposed Expansion Space HVAC System Final Plans, the Expansion Space Rent Commencement Date shall be extended by one
(1) day for each day of delay of the completion of the Expansion Space Tenant Improvements and the Expansion Space HVAC System Work caused solely by Landlord’s failure to timely respond within such additional five (5) business day
period. 
 C. COST OF TENANT IMPROVEMENTS/ALLOWANCES 
 1. Construction Costs. As used herein, the term “Construction Costs” shall mean (a) all costs of design and
construction of the Tenant Improvements, including without limitation the costs of all space planning, architectural and engineering work related thereto, all governmental and quasi-governmental approvals and permits required therefor, any costs
incurred by Landlord because of changes to the base Building or the Base Building Systems, all construction costs, contractors’ overhead and profit, insurance and other requirements, the cost of Tenant’s telecommunications cabling and
wiring, moving expenses (excluding legal fees), architectural, design and project management fees and all other costs and expenses incurred in connection with the Tenant Improvements, and (b) all costs related to the performance of the
Expansion Space HVAC System Work in accordance with Paragraph 4.E of the Second Amendment above (collectively, the “Expansion Space HVAC System Work Costs”). All Construction Costs shall be paid by Tenant, subject, however, to the
application of the Improvement Allowance in accordance with Paragraph C.2, below, not previously disbursed pursuant to this Work Agreement (the “Available Allowance”). 
 2. Improvement Allowance. Provided Tenant is not in default of the Lease beyond any applicable notice and cure
periods, Landlord agrees to provide to Tenant an allowance (the “Improvement Allowance”) in an amount up to One Hundred Sixty-Four Thousand Four Hundred and  58/100 Dollars ($164,400.58) (or Thirty-One and  06/100 Dollars ($31.06) per rentable square foot of the Expansion
Space) to be applied solely to the Construction Costs; provided, however, that a minimum of Eighty-Two Thousand Two Hundred and  29/
100 Dollars ($82,200.29) (equal to Fifteen and  53/
100 Dollars ($15.53) per rentable square foot of the Expansion Space) of the Improvement Allowance (the “Expansion Space Improvement Allowance”) shall be
devoted exclusively to Hard Costs (hereinafter defined) related to the construction of Tenant Improvements to be located in the Expansion Space only and Hard Costs related to the performance of the Expansion Space HVAC System Work. As used herein,

  

					
		 	Exhibit B, Page 5	 	

 
the term “Hard Costs” shall mean actual construction costs and shall not include architectural and engineering design fees, the cost of furniture, cabling, telephones and computers, or
any moving costs. Provided that Tenant has fully performed all of its obligations under the Lease and this Work Agreement, Construction Costs shall be disbursed by Landlord from the Available Allowance, as and when such costs are actually incurred
by Tenant. Tenant shall submit to Landlord, from time to time, but not more often then once per calendar month, requests for direct payments to third parties, of or for reimbursement to Tenant for Construction Costs incurred by Tenant out of the
Available Allowance, which requests shall be accompanied by (a) paid receipts or invoices substantiating the costs for which payment is requested; (b) a signed statement from Tenant certifying that the costs were actually incurred for the
stated amount; (c) lien waivers from the party supplying the services or materials for which payment is sought; and (d) such other information as Landlord reasonably requires. Provided Tenant delivers to Landlord an approved draw request,
prepared as set forth above, Landlord shall pay the costs covered by such payment request within thirty (30) days following receipt thereof (but Landlord shall not be obligated to make more than one (1) such payment in any calendar month).
Notwithstanding the foregoing, in no event shall Landlord be obligated to pay, in the aggregate, an amount in excess of ninety percent (90%) of the Improvement Allowance until satisfaction of the following conditions: (A) Tenant’s
occupancy of the Expansion Space; (B) receipt by Landlord of appropriate paid receipts or invoices and a final lien waiver from each subcontractor and supplier covering all work performed by the subcontractors and all materials used in
connection with the construction of the Tenant Improvements and the performance of the Expansion Space HVAC System Work; and (C) Tenant’s delivery to Landlord of all receipts, invoices or other documentation necessary to substantiate all
costs payable by Landlord hereunder. Any portion of the Improvement Allowance not expended by Tenant in undertaking the Tenant Improvements or the Expansion Space HVAC System Work within nineteen (19) months after the Effective Date shall be
retained by Landlord and Tenant shall have no further right or claim to such retained portion of Improvement Allowance. 
 3.
Excess Cost Allowance. In the event that Tenant notifies Landlord in writing (the “Excess Cost Notice”), on or before December 31, 2008, that Tenant wishes to increase the Improvement Allowance, and specifies the amount of such
proposed increase, not to exceed the Maximum Increase Amount (hereinafter defined), and evidences to Landlord’s satisfaction that (a) the cost of undertaking the Tenant Improvements and the Expansion Space HVAC System Work exceeds the
Improvement Allowance by the approximate amount of the Excess Cost Allowance (hereinafter defined) requested by Tenant; and (b) Tenant is capable of repaying such Excess Cost Allowance pursuant to the terms of this Paragraph C.3, then Landlord
shall make available to Tenant an additional allowance (the “Excess Cost Allowance”) in the amount requested by Tenant, but not to exceed the Maximum Increase Amount, to be applied solely to the Construction Costs. To facilitate
Landlord’s review of Tenant’s ability to repay the Excess Cost Allowance, Tenant shall include current financial statements satisfactory to Landlord with the Excess Cost Notice. Landlord, Landlord’s lenders and potential lenders, and
potential purchasers of the Building shall keep confidential all financial information of Tenant thus disclosed. As used herein, the term “Maximum Increase Amount” means the sum of One Hundred Five Thousand Eight Hundred Sixty Dollars
($105,860.00) (or Twenty Dollars ($20.00) per rentable square foot of the Expansion Space). The Excess Cost Allowance shall be paid out by the Landlord in accordance with the provisions of the Work Agreement. Tenant shall repay to Landlord the
amount of the Excess Cost Allowance over the Expansion Space Term (beginning on the Expansion Space Commencement Date) in equal monthly installments in the amount necessary to fully repay to Landlord the Excess Cost Allowance, with interest at the
rate of eight percent (8%) per annum, compounded monthly on a constant collection basis, on the outstanding amount thereof, as though the Excess Cost Allowance were a loan made by Landlord to Tenant on the Expansion Space Commencement Date.
Such equal monthly installments shall be considered Base Rent under the Lease and shall be paid together with, and in the same manner as, Expansion Space Monthly Base Rent payable by Tenant pursuant the Second Amendment, provided that such
installments shall not be subject to the annual escalations applicable to Expansion Space Monthly Base Rent. Upon any termination of the Lease, Tenant shall be immediately obligated to repay to Landlord the entire amount of the Excess Cost Allowance
that has not previously been repaid, plus any accrued and unpaid interest thereon, and such obligation shall survive any such termination. 
  

					
		 	Exhibit B, Page 6	 	

 4. Costs Exceeding Available Allowance. All Construction Costs in excess of the
Available Allowance (as may be increased by the Maximum Increase Amount) shall be paid solely by Tenant on or before the date such costs are due and payable (or if previously paid by Landlord, shall be reimbursed to Landlord by Tenant within ten
(10) days of receipt by Tenant of invoices therefor from Landlord), and Tenant agrees to indemnify Landlord from and against any such costs. All amounts payable by Tenant pursuant to this Work Agreement shall be deemed to be Additional Rent for
purposes of the Lease. If required by Landlord, Tenant shall provide evidence satisfactory to Landlord that Tenant has sufficient funds available to pay all Construction Costs in excess of the Improvement Allowance. 
 D. CONSTRUCTION 
 1. General Contractor. Tenant shall retain a general contractor licensed in the State of North Carolina and reasonably approved by Landlord to undertake construction of the Tenant Improvements (the “Contractor”). The
Contractor shall be responsible for obtaining, at Tenant’s cost, all permits and approvals required for the construction of the Tenant Improvements. 
 2. Construction By The Contractor. In undertaking the Tenant Improvements, Tenant and the Contractor shall strictly comply with the following conditions: 
 a. No work involving or affecting the Building’s structure and no work involving or materially and adversely affecting the Base
Building Systems shall be undertaken without (i) the prior written approval of Landlord in accordance with the terms and provisions of this Work Agreement, whether pursuant to its approval of Tenant’s Plans or otherwise, (ii) the
supervision of Landlord’s building engineer, the actual cost of which shall be borne by Landlord, or, if such work requires Landlord, in its reasonable discretion, to contract with a third party engineer, the supervision of such third party
engineer, it being agreed by Landlord and Tenant that the actual cost of any such third party engineer shall be borne by Landlord; (iii) compliance by Tenant with the insurance requirements set forth in Paragraph D.2(c), below; and
(iv) compliance by Tenant with all of the terms and provisions of this Work Agreement; 
 b. All Tenant Improvement work
shall be performed in strict conformity with (i) the final approved Tenant’s Plans; (ii) all applicable codes and regulations of governmental authorities having jurisdiction over the Building and the Premises; (iii) valid
building permits and other authorizations from appropriate governmental agencies, when required, which shall be obtained by Tenant, at Tenant’s expense; and (iv) Landlord’s construction policies, rules and regulations attached hereto
as Schedule C-3, as the same may be reasonably modified by Landlord from time to time and provided to Tenant in advance in writing (“Construction Rules”). Any Tenant Improvements not acceptable to the appropriate governmental
agencies or not reasonably satisfactory to Landlord shall be promptly replaced at Tenant’s sole expense. Notwithstanding any failure by Landlord to object to any such work, Landlord shall have no responsibility therefor; and 
 c. Before any work is commenced or any of Tenant’s, Contractor’s or any subcontractor’s equipment is moved onto any part of
the Building, Tenant shall deliver to Landlord policies or certificates evidencing the following types of insurance coverage in the following minimum amounts, which policies shall be issued by companies approved by Landlord, shall be maintained by
Tenant at all times during the performance of the Tenant Improvements, and which shall name Landlord as additional insured: 
 (i) Worker’s compensation coverage in the maximum amount required by law and employer’s liability insurance in an amount not less than $500,000.00 and $500,000.00 per disease; 
 (ii) Comprehensive general liability policy to include products/completed operations, premises/operations, blanket contractual broad form
property damage and contractual liability with limits in an amount per occurrence of not less than $1,000,000.00 Combined Single Limit for bodily injury and property damage and $1,000,000.00 for personal injury; and 
  

					
		 	Exhibit B, Page 7	 	

 (iii) Automobile liability coverage, with bodily injury limits of at least $1,000,000.00
per accident. 
 3. Construction Supervision. Landlord and Tenant hereby acknowledge and agree that, as an additional
concession to Tenant with respect to Tenant’s leasing of the Expansion Space, Tenant shall not be obligated to pay Landlord, or any construction supervisor of Landlord, a construction supervision fee with respect to the construction of the
Tenant Improvements. 
 E. PERMITS AND LICENSES. Tenant shall be solely responsible for procuring, at its sole cost and
expense, all permits and licenses necessary to undertake the Tenant Improvements and, upon completion of the Tenant Improvements with respect to the Expansion Space only, to occupy the Expansion Space. Tenant’s inability to obtain, or delay in
obtaining, any such license or permit shall not delay or otherwise affect the Expansion Space Commencement Date, the Expansion Space Rent Commencement Date or any of Tenant’s obligations under the Lease. 
 F. INSPECTION. Landlord is authorized, at its sole cost and expense, to make such inspections of the Expansion Space during
construction as it deems reasonably necessary or advisable. 
 G. INDEMNIFICATION. Except to the extent caused by the
gross negligence or willful misconduct of Landlord, its agents or employees, Tenant shall indemnify Landlord and hold it harmless from and against all claims, injury, damage or loss (including reasonable attorneys’ fees) sustained by Landlord
as a result of the construction of the Tenant Improvements. 
 LIST OF EXHIBITS AND SCHEDULES 
  

			
	Exhibit B-1	  	Expansion Space Final Space Plan
	Schedule B-1	  	Original Premises Proposed Space Plan Requirements
	Schedule B-2	  	Requirements for Contract Documents
	Schedule B-3	  	Construction Rules and Regulations

  

					
		 	Exhibit B, Page 8	 	

 EXHIBIT B-1 
 EXPANSION SPACE FINAL SPACE PLAN 
 [diagrams omitted]

  

					
		 		 	

 SCHEDULE B-1 
 ORIGINAL PREMISES PROPOSED SPACE PLAN REQUIREMENTS 
 Floor plans,
together with related information for mechanical, electrical and plumbing design work, showing partition arrangement and reflected ceiling plans (three (3) sets), including without limitation the following information: 
  

	 	a.	identify the location of conference rooms and density of occupancy; 

  

	 	b.	indicate the density of occupancy for all rooms; 

  

	 	c.	identify the location of any food service areas or vending equipment rooms; 

  

	 	d.	identify areas, if any, requiring twenty-four (24) hour air conditioning; 

  

	 	e.	indicate those partitions that are to extend from floor to underside of structural slab above or require special acoustical treatment; 

  

	 	f.	identify the location of rooms for, and layout of, telephone equipment other than building core telephone closet; 

  

	 	g.	identify the locations and types of plumbing required for toilets (other than core facilities), sinks, drinking fountains, etc.; 

  

	 	h.	indicate light switches in offices, conference rooms and all other rooms in the Expansion Space; 

  

	 	i.	indicate the layouts for specially installed equipment, including computer and duplicating equipment, the size and capacity of mechanical and electrical services
required and heat rejection of the equipment; 

  

	 	j.	indicate the dimensioned location of: (A) electrical receptacles (one hundred twenty (120) volts), including receptacles for wall clocks, and telephone
outlets and their respective locations (wall or floor), (B) electrical receptacles for use in the operation of Tenant’s business equipment which requires two hundred eight (208) volts or separate electrical circuits,
(C) electronic calculating and CRT systems, etc., and (D) special audio-visual requirements; 

  

	 	k.	indicate proposed layout of sprinkler and other life safety and fire protection equipment, including any special equipment and raised flooring;

  

	 	l.	indicate the swing of each door; 

  

	 	m.	indicate a schedule for doors and frames, complete with hardware, if applicable; and 

  

	 	n.	indicate any special file systems to be installed. 

  

					
		 	Schedule B-1	 	

 SCHEDULE B-2 
 REQUIREMENTS FOR CONTRACT DOCUMENTS 
 Final architectural detail and
working drawings, finish schedules and related plans (three (3) reproducible sets) including without limitation the following information and/or meeting the following conditions: 
  

	 	a.	materials, colors and designs of wallcoverings, floor coverings and window coverings and finishes; 

  

	 	b.	paintings and decorative treatment required to complete all construction; 

  

	 	c.	complete, finished, detailed mechanical, electrical, plumbing and structural plans and specifications for the Tenant Improvements, including but not limited to the fire
and life safety systems and all work necessary to connect any special or non-standard facilities to the Building’s base mechanical systems; 

  

	 	d.	all final drawings and blueprints must be drawn to a scale of one-eighth (l/8) inch to one (l) foot. Any architect or designer acting for or on behalf of Tenant
shall be deemed to be Tenant’s agent and authorized to bind Tenant in all respects with respect to the design and construction of the Original Premises and/or Expansion Space, as applicable; and 

  

	 	e.	Tenant shall not perform any work which would: (1) except as otherwise approved by Landlord in accordance with this Second Amendment and the Work Agreement,
require changes to structural components of the Building or the exterior design of the Building; (2) except as otherwise approved by Landlord in accordance with this Second Amendment and the Work Agreement, require any material modification to
the Base Building Systems; (3) not comply with all applicable laws, rules, regulations and requirements of any governmental department having jurisdiction over the construction of the Building, the Original Premises and/or the Expansion Space,
including specifically, but without limitation, the Americans with Disabilities Act; (4) be incompatible with the building plans filed with the appropriate governmental agency from which a building permit is obtained for the construction of the
Tenant Improvements or with the occupancy of the Building as a first-class flex space building; or (5) delay the completion of the Tenant Improvements in the Original Premises and/or Expansion Space or any part thereof, as applicable. Tenant
shall not oppose or delay changes required by any governmental agency affecting the construction of the Building and/or the Tenant Improvements. 

  

					
		 	Schedule B-2	 	

 SCHEDULE B-3 
 CONSTRUCTION RULES AND REGULATIONS 
  

	1.	Tenant and/or the general contractor will supply Landlord with a copy of all permits (if applicable) prior to the start of any work. 

  

	2.	Tenant and/or the general contractor will post the building permit (if applicable) on a wall of the construction site while work is being performed.

  

	3.	Public area corridor, and carpet, is to be protected by plastic runners or a series of walk-off mats from the elevator to the suite under reconstruction.

  

	4.	Walk-off mats are to be provided at entrance doors. 

  

	5.	Contractors will remove their trash and debris daily, or as often as necessary to maintain cleanliness in the Building. Building trash containers are not to be used for
construction debris. Landlord reserves the right to bill Tenant for any cost incurred to clean up debris left by the general contractor or any subcontractor. Further, the Building staff is instructed to hold the driver’s license of any employee
of the contractor while using the freight elevator to ensure that all debris is removed from the elevator. 

  

	6.	No utilities (electricity, water, gas, plumbing) or services to the tenants are to be cut off or interrupted without first having requested, in writing, and secured, in
writing, the permission of Landlord. 

  

	7.	No electrical services are to be put on the emergency circuit, without specific written approval from Landlord. 

  

	8.	When utility meters are installed, the general contractor must provide the property manager with a copy of the operating instructions for that particular meter.

  

	9.	Landlord will be notified of all work schedules of all workmen on the job and will be notified, in writing, of names of those who may be working in the building after
“normal” business hours. 

  

	10.	Passenger elevators shall not be used for moving building materials and shall not be used for construction personnel except in the event of an emergency. The designated
freight elevator is the only elevator to be used for moving materials and construction personnel. This elevator may be used only when it is completely protected as determined by Landlord’s Building engineer. 

  

	11.	Contractors or personnel will use loading dock area for all deliveries and will not use loading dock for vehicle parking. 

  

	12.	Contractors will be responsible for daily removal of waste foods, milk and soft drink containers, etc. to trash room and will not use any building trash receptacles but
trash receptacles supplied by them. 

  

	13.	No building materials are to enter the Building by way of main lobby, and no materials are to be stored in any lobbies at any time. 

  

	14.	Construction personnel are not to eat in the lobby or in front of Building nor are they to congregate in the lobby or in front of Building. 

  

	15.	Landlord is to be contacted by Tenant when work is completed for inspection. All damage to the Building will be determined at that time. 

  

	16.	All key access, fire alarm work, or interruption of security hours must be arranged with Landlord’s Building engineer. 

  

	17.	There will be no radios allowed on job site. 

  

	18.	All workers are required to wear a shirt, shoes, and full length trousers. 

  

					
		 	Schedule B-3	 	

	19.	Protection of hallway carpets, wall coverings, and elevators from damage with masonite board, carpet, cardboard, or pads is required. 

  

	20.	Public spaces — corridors, elevators, bathrooms, lobby, etc. — must be cleaned immediately after use. Construction debris or materials found in public areas
will be removed at Tenant’s cost. 

  

	21.	There will be no smoking, eating, or open food containers in the elevators, carpeted areas or public lobbies. 

  

	22.	There will be no yelling or boisterous activities. 

  

	23.	All construction materials or debris must be stored within the project confines or in an approved lock-up. 

  

	24.	There will be no alcohol or controlled substances allowed or tolerated. 

  

	25.	The general contractor and Tenant shall be responsible for all loss of their materials and tools and shall hold Landlord harmless for such loss and from any damages or
claims resulting from the work. 

  

					
		 	Schedule B-3, Page 2	 	

 EXHIBIT C 
 EXPANSION SPACE HVAC SYSTEM PRELIMINARY PLANS 
 [diagrams omitted] 

 EXHIBIT D 
 DECLARATION OF EXPANSION SPACE COMMENCEMENT DATE 
 This Declaration of Expansion Space Commencement Date is made as of                     , 2009, by ACP 2810 MERIDIAN LLC, a Delaware
limited liability company (“Landlord”), and ALDAGEN, INC., a Delaware corporation (“Tenant”), who agree as follows: 
 1. Landlord and Tenant entered into that certain Second Amendment to Lease Agreement dated
                    , 2008 (the “Second Amendment”), in which Landlord leased to Tenant, and Tenant leased from Landlord, certain premises
described therein and located at 2810 Meridian Parkway, Durham, North Carolina. All capitalized terms herein are as defined in the Second Amendment. 
 2. Pursuant to the Second Amendment, Landlord and Tenant agreed to and do hereby confirm the following matters as of the Expansion Space Commencement Date: 
  

	 	a.	the Expansion Space Commencement Date is January 1, 2009; 

  

	 	b.	the Expansion Space Rent Commencement Date is                     ,
20        ; 

  

	 	c.	the Expiration Date with respect to the Original Premises is April 30, 2013; 

  

	 	d.	the Expansion Space Expiration Date is December 31, 2013; and 

  

	 	e.	the number of rentable square feet comprising the Expansion Space is 5,293. 

 3. Tenant confirms that: 
  

	 	a.	it has accepted possession of the Expansion Space as provided in the Second Amendment; 

  

	 	b.	Landlord has fulfilled all its obligations to be provided to Tenant as of the date hereof; 

  

	 	c.	the Lease is in full force and effect and has not been modified, altered, or amended, except, as follows:
                    ; and 

  

	 	d.	there are no set-offs or credits against Rent, and no security deposit or prepaid rent has been paid, except as follows:
                    . 

 [signatures appear on the following page] 
  

					
		 	Exhibit D	 	

 The provisions of this Declaration of Expansion Space Commencement Date shall inure to the
benefit of, or bind, as the case may require, the parties and their respective successors and assigns, subject to the restrictions on assignment and subleasing contained in the Lease, and are hereby attached to and made a part of the Lease.

  

			
	LANDLORD:
	
	 ACP 2810 MERIDIAN LLC,
 a Delaware limited liability company

		
	By:	 	  

		 	Name:
		 	Title:
	
	TENANT:
	
	 ALDAGEN, INC.,
 a Delaware corporation

		
	By:	 	  

		 	Name:
		 	Title:

  

					
		 	Exhibit D, Page 2Exhibit 10.9

 Exhibit 10.9 
 ALDAGEN, INC. 
 AMENDED AND RESTATED 

INVESTOR RIGHTS AGREEMENT 
 December 15, 2006 

 TABLE OF CONTENTS 
  

							
	 	 	 	  	 	  	PAGE
	SECTION 1.	  	    RESTRICTIONS ON TRANSFER	  	2
				
		 	1.1	  	Restrictive Legend	  	2
		 	1.2	  	Notice of Proposed Transfers	  	3
		 	1.3	  	Transfer to Competitor	  	4
			
	SECTION 2.	  	    REGISTRATION RIGHTS	  	4
				
		 	2.1	  	Certain Definitions	  	4
		 	2.2	  	Demand Registration	  	5
		 	2.3	  	Piggyback Registration	  	7
		 	2.4	  	Expenses of Registration	  	9
		 	2.5	  	Obligations of the Company	  	9
		 	2.6	  	Indemnification	  	11
		 	2.7	  	Information by Holder	  	13
		 	2.8	  	Transfer of Rights	  	14
		 	2.9	  	Form S-3	  	14
		 	2.10	  	Delay of Registration	  	14
		 	2.11	  	Limitations on Subsequent Registration Rights	  	15
		 	2.12	  	Rule 144 Reporting	  	15
		 	2.13	  	“Market Stand Off” Agreement	  	15
		 	2.14	  	Amendment of Registration Rights	  	16
		 	2.15	  	Inclusion of Stock Held by Common Holders	  	16
		 	2.16	  	Termination of Rights	  	16
			
	SECTION 3.	  	    RIGHTS OF FIRST REFUSAL	  	16
				
		 	3.1	  	Certain Definitions	  	16
		 	3.2	  	Right of First Offer	  	17
		 	3.3	  	Required Notices	  	18
		 	3.4	  	Company’s Right to Sell	  	18
		 	3.5	  	Expiration of Right	  	18
			
	SECTION 4.	  	    KEY HOLDER TRANSFERS	  	18
				
		 	4.1	  	Certain Definitions	  	18
		 	4.2	  	Notice of Transfer	  	18

  

 -i- 

 TABLE OF CONTENTS 
 (CONTINUED) 
  

							
	 	 	 	  	 	  	PAGE
		 	4.3	  	Company Right of First Refusal	  	19
		 	4.4	  	Investor Right of First Refusal	  	19
		 	4.5	  	Right of Co-Sale	  	20
		 	4.6	  	Certain Transfers	  	21
		 	4.7	  	Expiration of Right	  	22
		 	4.8	  	Legend	  	22
		 	4.9	  	Assignment	  	22
			
	SECTION 5.	  	    COMPANY COVENANTS	  	23
				
		 	5.1	  	Affirmative Covenants	  	23
		 	5.2	  	Negative Covenants	  	27
		 	5.3	  	Press Release	  	28
		 	5.4	  	Board Consent Required	  	28
		 	5.5	  	Expiration of Covenants	  	29
			
	SECTION 6.	  	    VOTING AGREEMENT	  	29
				
		 	6.1	  	Election of Directors	  	29
		 	6.2	  	Binding Effect of Voting Agreement	  	29
		 	6.3	  	Legends	  	30
		 	6.4	  	Drag-Along Rights	  	30
		 	6.5	  	Irrevocable Proxy	  	31
		 	6.6	  	Termination of Voting Agreement	  	31
			
	SECTION 7.	  	    MISCELLANEOUS	  	31
				
		 	7.1	  	Governing Law	  	31
		 	7.2	  	Successors and Assigns	  	31
		 	7.3	  	Entire Agreement	  	31
		 	7.4	  	Severability	  	32
		 	7.5	  	Amendment and Waiver	  	32
		 	7.6	  	Delays or Omissions	  	32
		 	7.7	  	Notices, etc	  	33
		 	7.8	  	Titles and Subtitles	  	34
		 	7.9	  	Counterparts	  	34

  

 -ii- 

 TABLE OF CONTENTS 
  

					
	 	  	PAGE
	EXHIBITS	  	
			
	A	  	Schedule of Investors	  	
	B	  	Schedule of Junior Stock Holders	  	
	C	  	Schedule of Common Holders	  	
		
	SCHEDULES	  	
			
	5.2(a)	  	Indebtedness and Obligations	  	

  

 -i- 

 ALDAGEN, INC. 
 AMENDED AND RESTATED 
 INVESTOR RIGHTS AGREEMENT 

 THIS AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered
into as of this 15th day of December 2006, by and among
Aldagen, Inc., a Delaware corporation (the “Company”), the holders of the Company’s Series C Preferred Stock (the “Series C Stock”) listed on Exhibit A attached hereto (the
“Series C Holders,” or “Investors”), the holders of the Company’s Series A Preferred Stock (the “Series A Stock”) listed on Exhibit B attached hereto (the
“Series A Holders”), the holders of the Company’s Series B Preferred Stock (the “Series B Stock,” and together with the Series C Stock and Series A Stock, the “Preferred
Stock”) listed on Exhibit B attached hereto (the “Series B Holders,” and together with the Series C Holders and Series A Holders, the “Preferred Holders”), the holders of
warrants exercisable for shares of the Company’s Series B Stock (the “Warrants”) listed on Exhibit B attached hereto (the “Warrant Holders”), and those holders of the Company’s Common
Stock listed on Exhibit C attached hereto and holders of the Company’s Common Stock converted pursuant to Section 8 of Article IV of the Company’s Certificate of Incorporation as in effect on the date hereof solely for the
purposes of Sections 2.13, Section 4.1(a), Section 6, and Section 7 below (the “Common Holders”). The Series A Stock and Series B Stock shall collectively be referred to herein as “Junior
Stock” and the Series A Holders and the Series B Holders shall collectively be referred to herein as “Junior Holders.” 
 WHEREAS, the Company, the Series A Holders, and the Common Holders previously entered into that certain Investor Rights Agreement, dated as of October 18, 2000 (which agreement was amended and
restated by the Prior Investor Rights Agreement (as defined below)); 
 WHEREAS, the Company, the Junior Holders, the Warrant
Holders and the Common Holders have entered into that certain Amended and Restated Investor Rights Agreement, dated as of March 4, 2003, as amended (the “Prior Investor Rights Agreement”); 
 WHEREAS, the Company, the Junior Holders, the Warrant Holders and the Common Holders entered into that certain Amended and Restated Stock
Sale Agreement, dated as of March 3, 2003 (the “Stock Sale Agreement”); 
 WHEREAS, the Company
proposes to sell and issue up to 34,737,603 shares of its Series C Stock, pursuant to that certain Series C Preferred Stock Purchase Agreement, dated as of the date hereof, by and among the Company and the Series C Holders (the “Purchase
Agreement”), which financing the Company believes to be in the best interests of the Company and its stockholders; 
 WHEREAS, the Investors purchasing shares of Series C Stock, as a condition to entering into the Purchase Agreement, have requested that the Company, the Junior Holders and the Common Holders amend and restate the Prior Investor Rights
Agreement and terminate the Stock Sale Agreement as set forth herein; 

 WHEREAS, pursuant to Section 6.5 of the Prior Investor Rights Agreement, the amendment
of the Prior Investor Rights Agreement contemplated hereby requires the written consent of (i) the holders of at least 66-2/3% of the shares of the Junior Stock, voting together on an as-if-converted basis, (ii) the consent of the holders
of the majority of the shares of the Common Stock held by the Common Holders (other than BD Ventures, L.L.C.), and (iii) the Company (the “Requisite Approval”), and execution of this Agreement by the undersigned Junior Holders, the
Common Holders, and the Company satisfies such requirement; 
 WHEREAS, pursuant to Section 7.3 of the Stock Sale
Agreement, the termination of the Stock Sale Agreement contemplated hereby requires the written consent of (i) the holders of at least 66-2/3% of the shares of the Junior Stock, voting together on an as-if-converted basis, (ii) the consent
of the holders of the majority of the shares of the Common Stock held by the Common Holders (other than BD Ventures, L.L.C.), and (iii) the Company (the “Requisite Stock Sale Approval”), and execution of this Agreement by the
undersigned Junior Holders, the Common Holders, and the Company satisfies such requirement; 
 WHEREAS, in order to induce the
Company and the Series C Holders to enter into the Purchase Agreement, the Company, the Junior Holders, and the Common Holders hereby agree that this Agreement shall amend and restate the Prior Investor Rights Agreement and shall extend to the
Company and the Investors the rights and obligations as set forth below; 
 WHEREAS, in order to induce the Company and the
Series C Holders to enter into the Purchase Agreement, the parties thereto hereby agree that this Agreement shall terminate the Stock Sale Agreement and shall extend to the Company and the Investors the rights and obligations as set forth below; and

 NOW, THEREFORE, in consideration of the mutual agreements, covenants and conditions contained herein, the Company, the Series
C Holders, the Junior Holders and the Common Holders hereby agree as follows. 
 Section 1.  
 RESTRICTIONS ON TRANSFER 
 1.1 Restrictive Legend. Each certificate representing (i) the Preferred Stock, (ii) the Common Stock of the Company (the “Common Stock”) issued upon conversion of
the Preferred Stock, and (iii) any other securities issued in respect of the Preferred Stock or Common Stock issued upon conversion of the Preferred Stock upon any stock split, stock dividend, recapitalization, merger, consolidation or similar
event, shall (unless otherwise permitted by the provisions of Section 1.2 below) be stamped or otherwise imprinted with a legend in substantially the following form (in addition to any legend required under applicable state securities laws).

 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS

  

 2. 

 
AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE SOLD, MORTGAGED, PLEDGED,
HYPOTHECATED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND ANY APPLICABLE STATE SECURITIES LAWS, OR THE AVAILABILITY OF AN EXEMPTION FROM THE REGISTRATION
PROVISIONS OF THE SECURITIES ACT OF 1933, AS AMENDED, AND APPLICABLE STATE SECURITIES LAWS. COPIES OF THE STOCK PURCHASE AGREEMENT AND INVESTOR RIGHTS AGREEMENT, PROVIDING FOR RESTRICTIONS ON TRANSFER OF THESE SECURITIES MAY BE OBTAINED UPON WRITTEN
REQUEST BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF THE CORPORATION AT THE PRINCIPAL EXECUTIVE OFFICES OF THE CORPORATION. 
 Each Holder (as defined below) consents to the Company’s making a notation on its records and giving instructions to any transfer agent of the Preferred Stock or the Common Stock in order to
implement the restrictions on transfer established in this Section 1. Such legend shall be removed by the Company from any certificate at such time as the holder of the shares represented by the certificate satisfies the requirements of Rule
144(k) under the Securities Act of 1933, as amended (the “1933 Act”), provided that Rule 144(k) as then in effect does not differ substantially from Rule 144(k) as in effect as of the date of this Agreement and other
applicable regulations do not then require such legend to be included on the Preferred Stock or Common Stock, and provided further that the Company has received from the Holder a written representation that (i) such Holder is not an affiliate
of the Company and has not been an affiliate during the preceding three months, (ii) such Holder has beneficially owned the shares represented by the certificate for a period of at least two years, (iii) such Holder otherwise satisfies the
requirements of Rule 144(k) as then in effect with respect to such shares, and (iv) such Holder will submit the certificate for any such shares to the Company for reapplication of the legend at such time as the holder becomes an affiliate of
the Company or otherwise ceases to satisfy the requirements of Rule 144(k) as then in effect. 
 1.2 Notice of Proposed
Transfers. The holder of each certificate representing Registrable Securities (as defined below) by acceptance thereof agrees to comply in all respects with the provisions of this Section 1.2. Prior to any proposed sale, assignment,
transfer or pledge of any Registrable Securities, unless there is in effect a registration statement under the 1933 Act covering the proposed transfer, the holder thereof shall give written notice to the Company of such holder’s intention to
effect such transfer, sale, assignment or pledge. Each such notice shall describe the manner and circumstances of the proposed transfer, sale, assignment or pledge in sufficient detail, and shall be accompanied at such holder’s expense by a
written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company addressed to the Company, to the effect that the proposed transfer of the Registrable Securities may be effected without
registration under the 1933 Act. Each certificate evidencing the Registrable Securities transferred as above provided shall bear, except if such transfer is made pursuant to Rule 144, the appropriate restrictive legend set forth in Section 1.1
above, except that

  

 3. 

 
such certificate shall not bear such restrictive legend if in the opinion of counsel for such holder and the Company such legend is not required in order to establish compliance with any
provisions of the 1933 Act. Prior to any transfer of Registrable Securities in accordance with this Section 1, such transferee shall execute and deliver a form of agreement reasonably acceptable to the Company wherein the transferee agrees to
be bound by the provisions of this Section 1 and Section 2.13 hereof. 
 1.3 Transfer to Competitor. No Holder
shall transfer any Registrable Securities to a competitor of the Company, as determined by the Board of Directors of the Company in good faith. This provision shall terminate after the Company conducts a Qualified Public Offering (as defined in
Section 3.5 hereof). 
 Section 2. 
 REGISTRATION RIGHTS 
 The Company hereby grants to each of the Holders (as
defined below) the registration rights set forth in this Section 2, with respect to the Registrable Securities (as defined below) owned by such Holders. The Company and the Holders agree that the registration rights provided herein set forth
the sole and entire agreement, and supersede any prior agreement, between the Company and the Holders with respect to registration rights for the Company’s securities. 
 2.1 Certain Definitions. As used in this Section 2: 
 (a) The terms “register,” “registered” and “registration” refer to a
registration effected by filing with the Securities and Exchange Commission (the “SEC”) a registration statement (the “Registration Statement”) in compliance with the 1933 Act, and the declaration or
ordering by the SEC of the effectiveness of such Registration Statement. 
 (b) The term “Registrable
Securities” means (i) Common Stock issued or issuable upon conversion of the shares of Preferred Stock held by Preferred Holders or any transferee as permitted by Section 2.8 hereof, and (ii) any Common Stock issued as
(or issuable upon the conversion or exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to, or in exchange or in replacement of, such Registrable Securities; provided, however, that
shares of Common Stock or other securities shall only be treated as Registrable Securities if and so long as (A) they have not been sold to or through a broker or dealer or underwriter in a public distribution or a public securities
transaction, (B) they have not been sold in a transaction exempt from the registration and prospectus delivery requirements of the 1933 Act under Section 4(1) thereof so that all transfer restrictions and restrictive legends with respect
thereto are removed upon the consummation of such sale, and (C) the registration rights associated with such securities have not been terminated pursuant to Section 2.15 hereof. Notwithstanding the foregoing, Registrable Securities shall
not include any securities issued upon the conversion of shares of Series C Stock pursuant to Section 8 of Article IV of the Company’s Certificate of Incorporation as in effect on the date hereof. 
  

 4. 

 (c) The term “Holder” (collectively,
“Holders”) means each Preferred Holder and any transferee, as permitted by Section 2.8 hereof, holding Registrable Securities, securities exercisable or convertible into Registrable Securities or securities exercisable
for securities convertible into Registrable Securities. 
 (d) The term “Initiating Holders” means
(i) any Junior Holder or Junior Holders of 66-2/3% of the Registrable Securities then outstanding and not registered at the time of any request for registration made pursuant to Section 2.2 of this Agreement or (ii) the holders of a
majority of the Series C Stock (or a lesser percentage if the anticipated aggregate offering price for such offering is at least $10,000,000). 
 2.2 Demand Registration. 
 (a) Demand for Registration. If the
Company shall receive from Initiating Holders of Registrable Securities a written demand that the Company effect any registration (a “Demand Registration”) of Registrable Securities (other than a registration on Form S-3 or
any related form of registration statement, such a request being provided for under Section 2.9 hereof) then outstanding, the Company will: 
 (i) promptly (but in any event within 10 days) give written notice of the proposed registration to all other Holders; and 
 (ii) use its best efforts to effect such registration as soon as practicable and as will permit or facilitate the sale and distribution of all or such portion of such Initiating Holders’ Registrable
Securities as are specified in such demand, together with all or such portion of the Registrable Securities of any Holder or Holders joining in such demand as are specified in a written demand received by the Company within 15 days after such
written notice is given, provided that the Company shall not be obligated to take any action to effect any such registration pursuant to this Section 2.2: 
 (A) in any jurisdiction outside the United States or in any particular jurisdiction in which the Company would be required to execute a general consent to service of process in effecting such
registration, qualification or compliance unless the Company is already subject to service in such jurisdiction and except as may be required by the 1933 Act; 
 (B) after the Company has effected 2 registrations requested by the Junior Holders pursuant to this Section 2.2 and the sales of the shares of Common Stock under such registration have closed;

 (C) after the Company has effected 2 registrations requested by the Series C Holders pursuant to this Section 2.2
and the sales of the shares of Common Stock under such registration have closed; 
 (D) if the Company shall furnish to such
Holders a certificate, signed by the President of the Company, stating that, in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such Registration Statement
to be filed at the date filing would be required, then the Company shall have an additional period of not more than 90 days within which to file such Registration Statement; provided, however, that the Company shall not use this right more than once
in any 12-month period; 
  

 5. 

 (E) if within thirty (30) days of receipt of a written request from Holders pursuant
to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention to file a registration statement for a public offering, other than (i) pursuant to a registration statement relating to any employee benefit plan,
(ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, any registration statements related to the issuance or resale of securities issued in such a transaction, or (iii) pursuant to a
registration related to stock issued upon conversion of debt securities, within ninety (90) days; 
 (F) prior to the
earlier of (1) the third anniversary of the date of the initial closing of the sale of Series C Stock or (2) the date six months after the effective date of the initial public offering of the Company’s securities. 
 (b) Underwriting. If reasonably required to maintain an orderly market in the Common Stock, the Holders shall distribute the
Registrable Securities covered by their demand by means of an underwriting. If the Initiating Holders intend to distribute the Registrable Securities covered by their demand by means of an underwriting, they shall so advise the Company as part of
their demand made pursuant to this Section 2.2, including the identity of the managing underwriter; and the Company shall include such information in the written notice referred to in Section 2.2(a)(i). In such event, the right of any
Holder to registration pursuant to this Section 2.2 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided
herein. 
 The Company shall, together with all holders of capital stock of the Company proposing to distribute their securities
through such underwriting, enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company, which underwriter or underwriters shall be reasonably acceptable to a
majority-in-interest of the Initiating Holders. Notwithstanding any other provision of this Section 2.2, if the underwriter shall advise the Company that marketing factors (including, without limitation, an adverse effect on the per share
offering price) require a limitation of the number of shares to be underwritten (including Registrable Securities) (the “Underwriters’ Maximum Number”), then the Company will be obligated and required to include in such
registration that number of Registrable Securities requested by all Holders to be included in such registration, which does not exceed the Underwriters’ Maximum Number, and such number of Registrable Securities shall be allocated pro rata among
the Holders of such Registrable Securities on the basis of the number of Registrable Securities requested to be included therein by each such Holder. No Registrable Securities excluded from the underwriting by reason of the underwriter’s
marketing limitation shall be included in such registration. 
 If any Holder disapproves of the terms of the underwriting, such
Holder may elect to withdraw therefrom by written notice to the Company, the underwriter and the Initiating Holders. The Registrable Securities so withdrawn shall also be withdrawn from registration. 
  

 6. 

 The Company may include securities for its own account (or for the account of other
Stockholders) in such registration if the underwriter so agrees, but only to the extent the number of Registrable Securities would not thereby be limited. 
 2.3 Piggyback Registration. 
 (a) Company Registration. If at any
time or from time to time the Company shall determine to register any of its securities, either for its own account or for the account of security holders (other than a registration relating solely to employee benefits plan, a registration relating
to a corporate reorganization, a registration on Form S-4 relating solely to an SEC Rule 145 transaction (or subsequent similar rule), a registration pursuant to Section 2.2 or 2.9 hereof, or a registration in which the only Common Stock being
registered is Common Stock issuable upon conversion of debt securities that are also being registered), the Company will: 
 (i)
promptly (but in any event within 10 days after the Board of Directors approves retaining the underwriter) give to each Holder written notice thereof; and 
 (ii) include in such registration (and any related qualification under state securities laws or other compliance, subject to Section 2.2(a)(ii)(A)), and in any underwriting involved therein, all the
Registrable Securities specified in a written request or requests, made within 15 days after receipt of such written notice from the Company, by any Holder or Holders, except as set forth in Section 2.3(b) below (or if the Company could
complete registration prior to the 15 day notice period set forth above, include in a separate registration any Registrable Securities for which notices are received after registration but before expiration of the 15 day period described above).

 Such Registrable Securities shall only be included (i) to the extent that inclusion will not diminish the number of
securities included by the Company, and (ii) if such Registrable Securities can be included in the form of registration chosen by the Company under applicable securities rules and regulations. 
 (b) Underwriting. If the registration of which the Company gives notice is for a registered public offering involving an
underwriting, the Company shall so advise the Holders as a part of the written notice given pursuant to Section 2.3(a)(i). In such event the right of any Holder to registration pursuant to this Section 2.3 shall be conditioned upon such
Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. 
 All Holders proposing to distribute their Registrable Securities through such underwriting shall, together with the Company and the other parties distributing their securities through such underwriting,
enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. 
 Notwithstanding any other provision of this Section 2.3, if the underwriter determines that marketing factors require a limitation or reduction of the number of shares to be underwritten, the
underwriter may limit the number of Registrable Securities to be included in the registration and underwriting, subject to the terms of this Section 2.3. The Company shall so advise all holders of the Company’s securities that would
otherwise be registered and

  

 7. 

 
underwritten pursuant hereto, and the number of shares of such securities, including Registrable Securities, that may be excluded in the registration and underwriting shall be allocated in the
following manner: (i) shares held by persons who at that time do not have contractual registration rights shall have their shares excluded on a pro rata basis until the underwriters no longer require shares to be excluded from the registration
(“Level 1 Cutbacks”); (ii) if further cutbacks are required, shares held by employees and former employees of the Company that have contractual registration rights shall have their shares excluded until the underwriters
no longer require shares to be excluded from the registration (“Level 2 Cutbacks”); (iii) if further cutbacks are required, shares, including Registrable Securities, held by persons who have contractual rights to have
their shares included in the registration (excluding the holders of Series C Stock, employees and former employees of the Company) shall have their shares excluded until the underwriters no longer require shares to be excluded from the registration
(“Level 3 Cutbacks”); (iv) if further cutbacks are required, shares held by the holders of Series C Stock shall have their shares excluded until the underwriters no longer require shares to be excluded from the
registration (“Level 4 Cutbacks”); provided, that, in any registration other than a registration that is the Company’s initial public offering of securities, the amount of Series C Stock included in such registration
shall not be reduced below 30% of the total number of shares included in such registration; and (v) if further cutbacks are required, shares of the Company shall be excluded from the registration until the underwriters no longer require shares
to be excluded from the registration (“Level 5 Cutbacks”). If less than all the shares held by persons on the same level of cutbacks are required to be excluded to reduce the number of shares in the offering to the number the
underwriters want included in the registration, the shares that are included in the registration shall be allocated among the holders thereof in proportion, as nearly as practicable, to the amounts of Registrable Securities and such other securities
held by each such holder on that level of cutbacks at the time of filing the Registration Statement. 
 For purposes of any such
underwriter cutback, all Registrable Securities and other securities held by any Holder that is a partnership, limited liability company or corporation shall also include any Registrable Securities held by the partners, retired partners, members,
stockholders or affiliated entities of such Holder, or the estates and family members of any such partners, retired partners, members and any trusts for the benefit of any of the foregoing persons, and such Holder and other persons shall be deemed
to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in
such “selling Holder,” as defined in this sentence. The Company shall be entitled to rely on the written representation of any firm or entity as to whether any such affiliation exists. 
 No securities excluded from the underwriting by reason of the underwriter’s marketing limitation shall be included in such
registration. Nothing in this Section 2.3(b) is intended to diminish the number of securities to be included by the Company in the underwriting. 
 If any Holder disapproves of the terms of the underwriting, it may elect to withdraw therefrom by written notice to the Company and the underwriter. The Registrable Securities so withdrawn shall also be
withdrawn from registration. 
 (c) Right to Terminate Registration. The Company shall have the right to terminate or
withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. 
  

 8. 

 2.4 Expenses of Registration. All expenses incurred in connection with all
registrations effected pursuant to Sections 2.2, 2.3, and 2.9, including without limitation all registration, filing and qualification fees (including state securities law fees and expenses), printing expenses, escrow fees, fees and disbursements of
counsel for the Company (and the reasonable fees and disbursements of one separate special counsel for the participating Holders not to exceed $20,000 for a registration pursuant to Section 2.2(a) and $10,000 for a registration pursuant to
Sections 2.3 and 2.9) and expenses of any special audits incidental to or required by such registration shall be borne by the Company; provided, however, that the Company shall not be required to pay stock transfer taxes or
underwriters’ discounts or selling commissions relating to Registrable Securities. Notwithstanding anything to the contrary above, the Company shall not be required to pay for any expenses of any registration proceeding under Section 2.2
if the registration request is subsequently withdrawn at the request of the Holders of 66-2/3% of the Registrable Securities to have been registered, provided, however, that in the event that Holders holding at least 66-2/3% of the Registrable
Securities agree to forfeit their right to a demand registration pursuant to Section 2.2 (in which event such right shall be forfeited by all Holders), then the Company shall be required to pay the expenses of such withdrawn registration. In
the absence of such an agreement to forfeit, the Holders of Registrable Securities to have been registered shall bear all such expenses pro rata on the basis of the Registrable Securities to have been registered. Notwithstanding the preceding
sentence, however, if at the time of the withdrawal, the Holders have learned of a materially adverse change in the condition, business or prospects of the Company from that known to the Holders at the time of their registration request, then the
Holders shall not be required to pay any of said expenses and shall retain their rights pursuant to Section 2.2, unless within 20 days of written disclosure of such materially adverse change by the Company to the Holders, the Holders fail to
notify the Company of their intent to withdraw. 
 2.5 Obligations of the Company. Whenever required under this
Section 2 to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (a) prepare and file with the SEC a Registration Statement with respect to such Registrable Securities and use all commercially reasonable efforts to cause such Registration Statement to become effective, and keep such Registration
Statement effective for the lesser of 270 days or until the distribution contemplated in the Registration Statement has been completed; 
 (b) prepare and file with the SEC such amendments and supplements to such Registration Statement and the prospectus used in connection with such Registration Statement as may be necessary to keep such
Registration Statement effective and to comply with the provisions of the 1933 Act with respect to the disposition of all securities covered by such Registration Statement; 
 (c) furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements
of the 1933 Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them; 
  

 9. 

 (d) use all commercially reasonable efforts to register or otherwise qualify the securities
covered by such Registration Statement under such other securities laws of such states and other jurisdictions as shall be reasonably requested by the Holders or the managing underwriter, provided that the Company shall not be required in connection
therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions; 
 (e) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering;

 (f) notify each Holder of Registrable Securities covered by such Registration Statement of (x) any order the Securities
and Exchange Commission or any jurisdiction in which registration has been made terminating or suspending effectiveness or such registration or (y) at any time when a prospectus relating thereto is required to be delivered under the 1933 Act,
the happening of any event as a result of which the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary
to make the statements therein not misleading in the light of the circumstances then existing (in which case each Holder of Registrable Securities agrees to discontinue transactions in the Company’s securities until notified by the Company that
the conditions described above are no longer in effect), and at the request of any such Holder, prepare and furnish to such Holder a reasonable number of copies of a supplement or an amendment of such prospectus as may be necessary so that as
thereafter delivered to the purchasers of such shares, such prospectus shall not include an untrue statement of material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading
in the light of the circumstances then existing; 
 (g) cause all such Registrable Securities covered by such Registration
Statement to be listed with any securities exchange on which the Common Stock is then listed; 
 (h) make available for
inspection by each Holder including Registrable Securities in such registration, any underwriter participating in any distribution pursuant to such registration, and any attorney, accountant or other agent retained by such Holder or underwriter, all
financial and other records, pertinent corporate documents and properties of the Company, as such parties may reasonably request, and cause the Company’s officers, directors and employees to supply all information reasonably requested by any
such Holder, underwriter, attorney, accountant or agent in connection with such Registration Statement, provided that the Company may require reasonable confidentiality agreements and reasonable agreements restricting trading its stock to be signed
as a condition to disclosure; 
 (i) cooperate with Holders including Registrable Securities in such registration and the
managing underwriters, if any, to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold, such certificates to be in such denominations and registered in such names as such Holders or the
managing underwriters may request at least two business days prior to any sale of Registrable Securities; and 
  

 10. 

 (j) permit any Holder which Holder, in the sole and exclusive judgment, exercised in good
faith, of such Holder, might be deemed to be a controlling person of the Company, to participate in good faith in the preparation of such Registration Statement through a single legal counsel and to require insertion of material, furnished to the
Company in writing, that in the reasonable judgment of such Holder and its counsel should be included if a failure to include would expose Holder to a material risk of liability. 
 2.6 Indemnification. 
 (a) The Company will, and does hereby undertake to, indemnify and hold harmless each Holder of Registrable Securities, each of such Holder’s officers, directors, managers, partners, members and
agents, and each person controlling such Holder, with respect to any registration, qualification or compliance effected pursuant to this Section 2, and each underwriter, if any, and each person who controls any underwriter, of the Registrable
Securities held by or issuable to such Holder, against all claims, losses, damages and liabilities (or actions in respect thereto) to which they may become subject under the 1933 Act, the Securities Exchange Act of 1934, as amended (the
“1934 Act”), or other federal or state law arising out of or based on (i) any untrue statement (or alleged untrue statement) of a material fact contained in any prospectus, offering circular or other similar document
(including any related Registration Statement, notification, or the like) incident to any such registration, qualification or compliance, or based on any omission (or alleged omission) to state therein a material fact required to be stated therein
or necessary to make the statements therein not misleading in light of the circumstances in which they were made, (ii) any violation or alleged violation by the Company of any federal, state or common law rule or regulation applicable to the
Company and relating to any action or inaction required of the Company in connection with any such registration, qualification or compliance, or (iii) any failure to register or qualify Registrable Securities in any state where the Company or
its agents have affirmatively undertaken or agreed in writing that the Company (the undertaking of any underwriter chosen by the Company being attributed to the Company) will undertake such registration or qualification on behalf of the Holders of
such Registrable Securities and will reimburse, as incurred, each such Holder, each such underwriter and each such director, manager, officer, partner, member, agent and controlling person, for any legal and any other expenses reasonably incurred in
connection with investigating or defending any such claim, loss, damage, liability or action; provided that the Company will not be liable in any such case to the extent that any such claim, loss, damage, liability or expense arises out of or is
based on any untrue statement or omission made in conformity with written information furnished to the Company by an instrument duly executed by such Holder or underwriter and stated to be specifically for use therein. 
 (b) If Registrable Securities held by or issuable to such Holder are included in such registration, qualification, or compliance pursuant to
this Section 2, each Holder will and does hereby undertake to indemnify and hold harmless the Company, each of its directors and officers, and each person controlling (for purposes hereof, “control” or any form thereof shall have
within the meaning ascribed thereto in Section 15 of the 1933 Act) the Company, each underwriter, if any, and each person who controls any underwriter, of the Company’s securities

  

 11. 

 
covered by such a Registration Statement, and each other Holder, each of such other Holder’s officers, directors, managers, partners, members and agents and each person controlling such
other Holder, against all claims, losses, damages and liabilities (or actions in respect thereof) arising out of or based on (i) any failure of such Holder or its agents or representatives to comply with the prospectus delivery requirements of
the 1933 Act or any other applicable securities or Blue Sky law, or (ii) any untrue statement (or alleged untrue statement) of a material fact contained in any such Registration Statement, prospectus, offering circular or other document, or any
omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances in which they were made, and will reimburse, as incurred, the
Company, each such underwriter, each such other Holder, and each such director, officer, manager, partner, member, agent, and controlling person of the foregoing, for any legal or any other expenses reasonably incurred in connection with
investigating or defending any such claim, loss, damage, liability or action, in each case to the extent, but only to the extent, that such untrue statement (or alleged untrue statement) or omission (or alleged omission) was made in such
Registration Statement, prospectus, offering circular or other document, in reliance upon and in strict conformity with written information furnished to the Company by an instrument duly executed by such Holder and stated to be specifically for use
therein (or related registration statement, notification or the like) or any amendment or supplement thereto and except that the foregoing indemnity agreement is subject to the condition that, insofar as it relates to any such untrue statement (or
alleged untrue statement) or omission (or alleged omission) made in the preliminary prospectus but eliminated or remedied in the amended prospectus on file with the SEC at the time the registration statement becomes effective or in the final
prospectus, such indemnity agreement shall not inure to the benefit of (i) the Company and (ii) any underwriter or any Holder, if there is no underwriter, if a copy of the final prospectus was not furnished to the person or entity
asserting the loss, liability, claim or damage at or prior to the time such furnishing is required by the 1933 Act; provided, further, that this indemnity shall not be deemed to relieve any underwriter of any of its due diligence obligations;
provided, further, that the indemnity agreement contained in this subsection 2.6(b) shall not apply to amounts paid in settlement of any such claim, loss, damage, liability or action if such settlement is effected without the consent of the Holder,
which consent shall not be unreasonably withheld; and provided, further, that the liability of each Holder hereunder (unless such Holder’s liability hereunder is based upon such Holder’s willful misconduct as determined by the
nonappealable final decision of a court) shall be limited to the proportion of any such claim, loss, damage or liability that is equal to the proportion that the public offering price of the shares sold by such Holder under such Registration
Statement bears to the total public offering price of all securities sold thereunder, but in any event not to exceed the net proceeds received by such Holder from the sale of securities under such Registration Statement. It is understood and agreed
that the indemnification obligations of each Holder pursuant to any underwriting agreement entered into in connection with any Registration Statement shall be limited to the obligations contained in this subsection 2.6(b). 
 (c) Each party entitled to indemnification under this Section 2.6 (the “Indemnified Party”) shall give notice
to the party required to provide such indemnification (the “Indemnifying Party”) of any claim as to which indemnification may be sought promptly after such Indemnified Party has actual knowledge thereof, and shall permit the
Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom with counsel mutually satisfactory to the parties; provided, however, that (i) a party shall not unreasonably withhold its

  

 12. 

 
agreement with respect to the selection of such counsel, (ii) an Indemnified Party (together with all other Indemnified Parties that may be represented without conflict by one counsel) shall
have the right to retain one separate counsel, with the fees and expenses to be paid by the Indemnifying Party, if representation of such Indemnified Party by the counsel retained by the Indemnifying Party would be inappropriate due to actual or
potential differing interests between such Indemnified Party and any other party represented by such counsel in such proceeding, and (iii) the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying
Party of its obligations under this Section 2, except to the extent that such failure to give notice shall materially adversely affect the Indemnifying Party in the defense of any such claim or any such litigation. No Indemnifying Party, in the
defense of any such claim or litigation, shall, except with the consent of each Indemnified Party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or
plaintiff therein, to such Indemnified Party, of a release from all liability with respect to such claim or litigation. 
 (d)
In order to provide for just and equitable contribution to joint liability under the 1933 Act in any case in which either (i) any Holder exercising rights under this Agreement, or any controlling person of any such Holder, makes a claim for
indemnification pursuant to this Section 2.6 but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that
such indemnification may not be enforced in such case notwithstanding the fact that this Section 2.6 provides for indemnification in such case, or (ii) contribution under the 1933 Act may be required on the part of any such Holder or any
such controlling person in circumstances for which indemnification is provided under this Section 2.6, then, and in each such case, the Company and such Holder will contribute to the aggregate claims, losses, damages or liabilities to which
they may be subject (after contribution from others) in such proportion so that such Holder is responsible for the portion represented by the percentage that the public offering price of the securities offered by such Holder pursuant to the
Registration Statement bears to the public offering price of all securities offered by such Registration Statement, and the Company will be responsible for the remaining portion (without prejudice as to the Company’s right to contributions from
any other responsible parties); provided, however, that, in any case, (A) no such Holder will be required to contribute any amount in excess of the public offering price of all securities offered by it pursuant to such Registration Statement,
after deduction of underwriting discounts and commissions (unless such Holder’s liability hereunder is based upon such Holder’s willful misconduct as determined by the nonappealable final decision of a court); and (B) no person or
entity guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) will be entitled to contribution from any person or entity who was not guilty of such fraudulent misrepresentation. 
 (e) The indemnities provided in this Section 2.6 shall survive the transfer of any Registrable Securities by such Holder. 

2.7 Information by Holder. The Holder or Holders of Registrable Securities included in any registration shall furnish to the
Company such information regarding such Holder or Holders and the distribution proposed by such Holder or Holders as the Company may reasonably request in writing and as shall be required in connection with any registration, qualification or
compliance referred to in this Section 2. 
  

 13. 

 2.8 Transfer of Rights. The rights contained in Sections 2 hereof may be assigned or
otherwise conveyed to (i) any principal, partner, officer, or retired principal, partner, or officer of an Investor, (ii) any transferee, other than a competitor of the Company, receiving at least Three Hundred Thousand
(300,000) shares of Registrable Securities, (iii) any partner, retired partner or affiliated fund of any Holder which is a partnership, (iv) any member of former member of any Holder which is a limited liability company, (v) any
family member or trust for the benefit of any individual holder, or (vi) any transferee receiving at least 100,000 shares of Series C Stock, who shall be considered a “Holder” for purposes hereof, provided that such transfer is
effected in compliance with Section 1.2 hereof and such transferee agree to be bound by the terms of this Agreement. 
 2.9
Form S-3. The Company shall use all commercially reasonable efforts to qualify for registration on Form S-3. After the Company has qualified for the use of Form S-3, the Holders holding no less than 20% of the Registrable Securities or a
Series C Holder shall have the right to request registrations on Form S-3 thereafter under this Section 2.9. The Company shall promptly give notice to all Holders of Registrable Securities of the receipt of a request for registration pursuant
to this Section 2.9 and shall provide a reasonable opportunity for other Holders to participate in the registration. Subject to the foregoing, the Company will use its best efforts to effect as soon as practicable the registration of all shares
of Registrable Securities on Form S-3 to the extent requested by the Holder or Holders thereof for purposes of disposition; provided, however, that the Company shall not be obligated to effect any such registration (A) if the
Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than
$1,000,000, (B) with respect to a request from a Series C Holder, at any time when the Company has effected two registrations requested by Series C Holders pursuant to this Section 2.9 during the preceding 12-month period, or
(C) with respect to a request from a Junior Holder, at any time when the Company has effected one registration requested by Junior Holders pursuant to this Section 2.9 during the preceding 12-month period. Notwithstanding the foregoing,
nothing herein shall restrict, prohibit or limit in any way a Holder’s ability to exercise its registration rights under Sections 2.2 or 2.3 hereof. The Company shall have no obligation to take any action to effect any registration pursuant to
this Section 2.9 for any of the reasons set forth in Section 2.2(a)(ii)(A) or (C) (which shall be deemed to apply to the obligations under this Section 2.9 with equal force). In addition, any registration pursuant to this
Section 2.9 shall be subject to the provisions of Section 2.2(b), which shall be deemed to apply to the obligations under this Section 2.9 with equal force, except that any reference therein to Section 2.2 or a subsection thereof
shall, for these purposes only, be deemed to be a reference to this Section 2.9. Subject to the foregoing, the Company shall file a Registration Statement covering the Registrable Securities and other securities so requested to be registered as
soon as practicable after receipt of the request or requests of the Holders. Registrations effected pursuant to this Section 2.9 shall not be counted as requests for registration effected pursuant to Section 2.2. 
 2.10 Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such
registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 
  

 14. 

 2.11 Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company shall not, (i) without the prior written consent of the Junior Holders of at least a 66 2/3% of the Junior Preferred Registrable Securities then outstanding and not registered, enter into any agreement with any holder or
prospective holder of any securities of the Company that would allow such holder or prospective holder (A) to have a level of priority on cutbacks that is more favorable to such persons(s) than the Level 3 Cutbacks afforded to the holders
pursuant to Section 2.3(b) or (B) to require the Company to register securities of such holder or prospective holder at any time earlier than the date specified in Section 2.2(a)(ii)(E) of this Agreement. From and after the date of
this Agreement, the Company shall not, (i) without the prior written consent of the Series C Holders of at least a 66 2/3% of the Series C Registrable Securities then outstanding and not registered, enter into any agreement with any holder
or prospective holder of any securities of the Company that would allow such holder or prospective holder (A) to have a level of priority on cutbacks that is more favorable to such persons(s) than the Level 4 Cutbacks afforded to the holders
pursuant to Section 2.3(b) or (B) to require the Company to register securities of such holder or prospective holder at any time earlier than the date specified in Section 2.2(a)(ii)(E) of this Agreement. 
 2.12 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and regulations of the SEC that
may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its diligent efforts to: 
 (a) make and keep current public information available, within the meaning of SEC Rule 144 or any similar or analogous rule promulgated under the 1933 Act, at all times after it has become subject to the
reporting requirements of the 1934 Act; 
 (b) file with the SEC, in a timely manner, all reports and other documents required
of the Company under the 1933 Act and 1934 Act (after it has become subject to such reporting requirements); and 
 (c) so long
as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request a (i) written statement by the Company as to its compliance with the reporting requirements of said Rule 144 (at any time commencing 90 days after the
effective date of the first registration filed by the Company for an offering of its securities to the general public), the 1933 Act and the 1934 Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a
registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies), (ii) copy of the most recent annual or quarterly report of the Company, and (iii) such other reports and documents as a Holder may
reasonably request in availing itself of any rule or regulation of the SEC allowing it to sell any such securities without registration. 
 2.13 “Market Stand Off” Agreement. Each Holder (including the Common Holders) hereby agrees that during a period, not to exceed 180 days, following the effective date of the initial,
effective registration statement of the Company filed under the 1933 Act, it shall not, to the extent requested by the Company and any underwriter, sell, pledge, transfer, make any short sale of, loan, grant any option for the purchase of, or
otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any Common Stock held by it at any time during such period except Common Stock included in such registration; provided, however, that all

  

 15. 

 
other stockholders with registration rights (whether or not pursuant to this Agreement) and all officers and directors of the Company enter into similar agreements. The foregoing provisions of
this Section 2.13 shall apply only to the Company’s initial public offering of equity securities, and shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement. If requested by any underwriter, all
stockholders shall execute and deliver to such underwriters an agreement in form reasonably acceptable to such underwriter evidencing the obligation described in this Section 2.13. 
 In order to enforce the foregoing covenant, the Company may impose stop transfer instructions with respect to the Registrable Securities of
each Holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 
 2.14 Amendment of Registration Rights. Subject to Section 6.5, any provision of this Section 2 may be amended and the observance thereof may be waived (either generally or in a particular instance and either retroactively
or prospectively), only with the written consent of the Company and the Holders of at least 66-2/3% of the Registrable Securities then outstanding and not registered. Notwithstanding the foregoing, any amendment that changes the rights of a Holder
in a manner materially and adversely different than all Holders shall require the approval of such Holder. Any amendment or waiver effected in accordance with this Section shall be binding upon each Holder, each future Holder of Registrable
Securities, and the Company. 
 2.15 Inclusion of Stock Held by Common Holders. In connection with any registration
effected pursuant to Section 2.3 hereof, the Common Holders shall be entitled to include in such registration (on the same terms and conditions as Holders selling their Registrable Securities in such registration) shares of Common Stock held by
such Common Holders; provided that any limitation by the underwriter on the number of shares to be underwritten in connection with such registration shall first be applied to the shares so included by such Common Holders before being applied to
shares of Registrable Securities, and provided further that each such Common Holder’s right to include shares of Common Stock in a registration pursuant to this Section 2.15 is contingent upon such Common Holder’s compliance with the
obligations of a Holder of Registrable Securities under this Agreement. 
 2.16 Termination of Rights. The rights of any
particular Holder under this Section 2 hereof shall terminate as to any Holder upon the date that is five years after the effective date of the sale of the Company’s shares of Common Stock in a firm commitment underwritten public offering
registered under the 1933 Act at a public offering per share price not less than five times the Series C Stock Original Issue Price (as defined in the Amended and Restated Charter, as amended from time to time, (“Restated
Charter”), subject to adjustment in the event of any stock dividends, stock splits or the like), with proceeds to the Company of not less than $30,000,000 (before deduction of underwriters’ commission and expenses) (a
“Qualified Public Offering”). 
 Section 3.  
 RIGHTS OF FIRST REFUSAL 
 3.1 Certain Definitions. As used in this Section 3: 
 (a) The term
“Major Investor” shall mean a Holder who holds at least 100,000 shares of Series C Stock. 
  

 16. 

 (b) The term “New Securities” shall mean any capital stock of the
Company, whether now authorized or not, and rights, options or warrants to purchase capital stock, and securities of any type whatsoever that are, or may become, convertible into capital stock; provided that the term “New Securities” does
not include: (i) the Investor Stock; (ii) securities issuable upon conversion of or with respect to Investor Stock; (iii) up to 5,949,000 shares of Common Stock, and options, warrants or rights convertible into such Common Stock,
issued to employees, consultants, officers or directors of the Company pursuant to any incentive agreement or arrangement approved by the Board of Directors of the Company (the “Permitted Stock”); (iv) securities issued
pursuant to any stock dividend, stock split, combination or other reclassification by the Company of any of its capital stock; (v) securities issuable upon conversion or exercise of any convertible security, option, warrant or other right to
acquire, if upon issuance of such convertible security, option, warrant or right the Company complied with the provisions of this Section 3; (vi) warrants to purchase shares of Common Stock issued to banks or equipment lessors, as approved
by the Board of Directors, such issuances not to exceed in the aggregate one percent (1%) of the outstanding shares of Common Stock of the Company on a fully-diluted, as-converted into Common Stock basis; (vii) shares of capital stock or
securities convertible into shares of capital stock issued in connection with business combinations or corporate partnering agreements, as approved by the Board of Directors, such issuances not to exceed in the aggregate five percent (5%) of
the outstanding shares of Common Stock of the Company on a fully-diluted, as-converted into Common Stock basis; or (viii) shares of Common Stock sold in connection with a Qualified IPO. 
 (c) The term “Pro Rata Share” means the ratio (i) the numerator of which is the number of shares of Common
Stock held by such Major Investor, or issuable to such Major Investor upon the conversion of shares of Series C Stock held by such Major Investor, on the date of the Company’s written notice pursuant to Section 3.4 hereof, and
(ii) the denominator of which is the number of shares of Common Stock outstanding, assuming for this purpose conversion or exercise of all securities convertible into or exercisable for Common Stock of the Company. 
 (d) The term “Transfer” shall include any sale, assignment, encumbrance, hypothecation, pledge, conveyance in trust,
gift, transfer by request, devise or descent, or other transfer or disposition of any kind, including, but not limited to, transfers to receivers, levying creditors, trustees or receivers in bankruptcy proceedings or general assignees for the
benefit of creditors, whether voluntary or by operation of law, directly or indirectly, of any of the Key Holder Stock. 
 3.2
Right of First Offer. The Company hereby grants to each Major Investor, subject to the terms and conditions specified in this Section 3, the right of first offer to purchase, on the terms and conditions set forth in the Company’s
notice pursuant to Section 3.3 hereof, up to its Pro Rata Share of all New Securities that the Company may, from time to time, propose to sell and issue. Each Major Investor may assign its right of first offer to purchase hereunder to an
affiliate of such Major Investor. 
  

 17. 

 3.3 Required Notices. In the event the Company proposes to undertake an issuance of
New Securities, it shall give each Major Investor written notice of its intention, describing the type of New Securities, the price and the general terms upon which the Company proposes to issue the same. Each Major Investor shall have 15 days from
the date of any such notice to exercise its right of first refusal under Section 3.2 hereof for the price and upon the general terms specified in the notice by giving written notice to the Company and stating therein the quantity of New
Securities to be purchased. 
 3.4 Company’s Right to Sell. The Company shall have 45 days after the 15-day period
described in Section 3.3 hereof to sell all such New Securities respecting which the Major Investors’ rights of first refusal hereunder were not exercised, at a price equal to and upon terms no more favorable in any material respect to the
purchasers thereof than those specified in the Company’s notice. In the event the Company has not sold all such New Securities within such 45 day period, the Company shall not thereafter issue or sell any New Securities without first notifying
the Major Investors in the manner provided herein. 
 3.5 Expiration of Right. The right of first offer granted under
this Section 3 shall not apply to, and shall expire upon, the effectiveness of a registration statement for a Qualified Public Offering or a Liquidating Event, as defined in the Company’s Fourth Amended and Restated Certificate of
Incorporation effective as of the date hereof. 
 Section 4. 
 KEY HOLDER TRANSFERS 
 4.1 Certain Definitions. As
used in this Section 4 and in Section 6: 
 (a) The term “Key Holder” shall mean a Junior
Holder, Common Holder, or W. Thomas Amick or Ed Field. 
 (b) “Key Holder Stock” shall mean shares of
the Company’s Common Stock now owned or subsequently acquired by the Key Holders by gift, purchase, dividend, option exercise or any other means whether or not such securities are only registered in a Key Holder’s name or beneficially or
legally owned by such Key Holder, including any interest of a spouse in any of the Key Holder Stock, whether that interest is asserted pursuant to marital property laws or otherwise. The number of shares of Key Holder Stock owned by the Key Holders
as of the date hereof are set forth on Exhibit A and Exhibit B, which Exhibits may be amended from time to time by the Company to reflect changes in the number of shares owned by the Key Holders, but the failure to so amend shall
have no effect on such Key Holder Stock being subject to this Agreement. 
 4.2 Notice of Transfer. If a Key
Holder proposes to transfer any shares of Key Holder Stock then the Key Holder shall promptly give written notice (the “Transfer Notice”) simultaneously to the Company and to each of the Investors at least thirty
(30) days prior to the closing of such transfer. The Transfer Notice shall describe in reasonable detail the proposed Transfer including, without limitation, the number of shares of Key Holder Stock to be transferred, the nature of such
Transfer, the consideration to be paid, and the name and address

  

 18. 

 
of each prospective purchaser or transferee. In the event that the Transfer is being made pursuant to the provisions of Section 4.6, the Transfer Notice shall state under which clause of
Section 4.6 the Transfer is being made. 
 4.3 Company Right of First Refusal. For a period of 10 days following
receipt of any Transfer Notice described in Section 4.2, the Company shall have the right to purchase all or a portion of the Key Holder Stock subject to such Transfer Notice on the same terms and conditions as set forth therein. The
Company’s purchase right shall be exercised by written notice signed by an officer of the Company (the “Company Notice”) and delivered to the Key Holder within such 10 day period. The Company shall effect the purchase of
the Key Holder Stock, including payment of the purchase price, not more than five business days after delivery of the Company’s Notice, and at such time the Key Holder shall deliver to the Company the certificate(s) representing the Key Holder
Stock to be purchased by the Company, each certificate to be properly endorsed for transfer. The Key Holder Stock so purchased shall thereupon be cancelled and cease to be issued and outstanding shares of the Company’s Common Stock. 

4.4 Investor Right of First Refusal. 
 (a) In the event that the Company does not elect to purchase all of the Key Holder Stock available pursuant to its rights under Section 4.3 within the period set forth therein, the Key Holder shall
promptly give written notice (the “Second Notice”) to each of the Investors, which shall set forth the number of shares of Key Holder Stock not purchased by the Company and which shall include the terms of Transfer Notice set
forth in Section 4.2. Each Investor shall then have the right, exercisable upon written notice to the Key Holder (the “Investor Notice”) within 10 days after the receipt of the Second Notice, to purchase its pro
rata share of the Key Holder Stock subject to the Second Notice and on the same terms and conditions as set forth therein. Except as set forth in Section 4.4(c), the Investors who so exercise their rights (the “Participating
Investors”) shall effect the purchase of the Key Holder Stock, including payment of the purchase price, not more than five days after delivery of the Investor Notice, and at such time the Key Holder shall deliver to the Participating
Investors the certificate(s) representing the Key Holder Stock to be purchased by the Participating Investors, each certificate to be properly endorsed for transfer. 
 (b) Each Investor’s pro rata share shall be equal to the product obtained by multiplying (i) the aggregate number of shares of Key Holder Stock covered by the Second Notice and
(ii) a fraction, the numerator of which is the number of shares of Common Stock issued or issuable upon the conversion or exercise of Preferred Stock or other rights to acquire shares of Common Stock held by the Participating Investor at the
time of the First Notice, and the denominator of which is the total number of shares of Common Stock issued or issuable upon the conversion or exercise of Preferred Stock or other rights to acquire shares of Common Stock at the time of the First
Notice held by all Investors. 
 (c) In the event that not all of the Investors elect to purchase their pro rata share of
the Key Holder Stock available pursuant to their rights under Section 4.4(a) within the time period set forth therein, then the Key Holder shall promptly give written notice to each of the Participating Investors (the “Overallotment
Notice”), which shall set forth the number of

  

 19. 

 
shares of Key Holder Stock not purchased by the other Investors, and shall offer such Participating Investors the right to acquire such unsubscribed shares. Each Participating Investor shall have
five days after receipt of the Overallotment Notice to deliver a written notice to the Key Holder (the “Participating Investors Overallotment Notice”) indicating the number of unsubscribed shares that such Participating
Investor desires to purchase, and each such Participating Investor shall be entitled to purchase such number of unsubscribed shares on the same terms and conditions as set forth in the Second Notice. In the event that the Participating Investors
desire, in the aggregate, to purchase in excess of the total number of available unsubscribed shares, then the number of unsubscribed shares that each Participating Investor may purchase shall be reduced on a pro rata basis. For purposes of this
Section 4.4(c) the denominator described in clause (ii) of subsection 4.4(b) shall be the total number of shares of Common Stock issued or issuable upon the conversion or exercise of Preferred Stock or other rights to acquire shares of
Common Stock held by all Participating Investors at the time of the First Notice. The Participating Investors shall then effect the purchase of the Key Holder Stock, including payment of the purchase price, not more than five days after delivery of
the Participating Investors Overallotment Notice, and at such time, the Key Holder shall deliver to the Investors the certificates representing the Key Holder Stock to be purchased by the Participating Investors, each certificate to be properly
endorsed for transfer. 
 4.5 Right of Co-Sale. 
 (a) In the event the Company and the Investors fail to exercise their respective rights to purchase all of the Key Holder Stock subject to
Sections 4.3 and 4.4 hereof, following the exercise or expiration of the rights of purchase set forth in Section 4.3 and 4.4, then the Key Holder shall deliver to the Company and each Investor written notice (the “Co-Sale
Notice”) that each Investor shall have the right, exercisable upon written notice to such Key Holder with a copy to the Company within 15 days after receipt of the Co-Sale Notice, to participate in such Transfer of Key Holder Stock on
the same terms and conditions. Such notice shall indicate the number of shares of Investor Stock up to that number of shares determined under Section 4.5(b) that such Investor wishes to sell under his or her right to participate. To the extent
one or more of the Investors exercise such right of participation in accordance with the terms and conditions set forth below, the number of shares of Key Holder Stock that such Key Holder may sell in the transaction shall be correspondingly
reduced. 
 (b) Each Investor may sell all or any part of that number of shares equal to the product obtained by multiplying
(i) the aggregate number of shares of Key Holder Stock covered by the Co-Sale Notice and not purchased by the Company or its assignees or Investors pursuant to Section 4.3 or 4.4 by (ii) a fraction the numerator of which is the number
of shares of Common Stock issued or issuable upon the conversion or exercise of Preferred Stock or other rights to acquire shares of Common Stock held by such Investor at the time of the First Notice and the denominator of which is the total number
of shares of Common Stock held by such Key Holder (excluding shares purchased by the Company and/or Investors pursuant to Section 4.3 or 4.4) plus the number of shares of Common Stock issued or issuable upon the conversion or exercise of
Preferred Stock or other rights to acquire shares of Common Stock held by all Investors at the time of the First Notice. 
  

 20. 

 (c) Each Investor who elects to participate in the Transfer pursuant to this
Section 4.6 (a “Co-Sale Participant”) shall effect its participation in the Transfer by promptly delivering to such Key Holder for transfer to the prospective purchaser one or more certificates, properly endorsed for
transfer, which represent: 
 (i) the type and number of shares of Common Stock which such Co-Sale Participant elects to sell;
or 
 (ii) that number of shares of Preferred Stock which is at such time convertible into the number of shares of Common Stock
which such Co-Sale Participant elects to sell; provided, however, that if the prospective purchaser objects to the delivery of Preferred Stock in lieu of Common Stock, such Co-Sale Participant shall convert such Preferred Stock into Common Stock and
deliver Common Stock as provided in Section 4.5(c)(i). The Company agrees to make any such conversion concurrent with and contingent upon the actual transfer of such shares to the purchaser. 
 (d) The stock certificate or certificates that the Co-Sale Participant delivers to such Key Holder pursuant to Section 4.5(c) shall be
transferred to the prospective purchaser in consummation of the sale of the Common Stock pursuant to the terms and conditions specified in the Co-Sale Notice, and the Key Holder shall concurrently therewith remit to such Co-Sale Participant that
portion of the sale proceeds to which such Co-Sale Participant is entitled by reason of its participation in such sale. To the extent that any prospective purchaser or purchasers prohibits such assignment or otherwise refuses to purchase shares or
other securities from a Co-Sale Participant exercising its rights of co-sale hereunder, such Key Holder shall not sell to such prospective purchaser or purchasers any Key Holder Stock unless and until, simultaneously with such sale, such Key Holder
shall purchase such shares or other securities from such Co-Sale Participant on the same terms and conditions specified in the Co-Sale Notice. 
 (e) The exercise or non-exercise of the rights of any Investor hereunder to participate in one or more Transfers of Key Holder Stock made by any Key Holder shall not adversely affect his right to
participate in subsequent Transfers of Key Holder Stock subject to Section 3. 
 (f) To the extent that the Investors do
not elect to participate in the sale of the Key Holder Stock subject to the Co-Sale Notice, such Key Holder may, not later than 90 days following delivery to the Company of the Co-Sale Notice, enter into an agreement providing for the closing of the
Transfer of such Key Holder Stock covered by the Co-Sale Notice within 60 days of such agreement on terms and conditions not materially more favorable to the transferor than those described in the Co-Sale Notice. Any proposed Transfer on terms and
conditions materially more favorable than those described in the Co-Sale Notice, as well as any subsequent proposed Transfer of any of the Key Holder Stock by a Key Holder, shall again be subject to the first refusal and co-sale rights of the
Company and/or Investors and shall require compliance by a Key Holder with the procedures described in this Section 4.5. 
 4.6 Certain Transfers. Notwithstanding the foregoing, the first refusal and co-sale rights of the Company and/or the Investors set forth in this Section 4 above shall not apply to (i) any transfer without consideration to
the Key Holder’s ancestors, descendants or spouse or to

  

 21. 

 
trusts for the benefit of such persons or the Key Holder, (ii) any transfer or transfers by a Key Holder to another Key Holder (the “Transferee-Key Holder”) so long
as the Transferee-Key Holder is, at the time of the transfer, employed by or acting as a consultant or director of the Company, or (iii) transfers to affiliates; provided that in the event of any transfer made pursuant to one of the
exemptions provided by clauses (i), (ii), and (iii), (A) the Key Holder shall inform the Investors of such pledge, transfer or gift prior to effecting it and (B) the pledgee, transferee or donee shall enter into a written agreement to be
bound by and comply with all provisions of this Agreement, as if it were an original Key Holder hereunder, including without limitation this Section 4. 
 4.7 Expiration of Right; Excluded Investors. The right of first refusal and right of co-sale granted under this Section 4 shall not apply to, and shall expire upon, the effectiveness of a
registration statement for a Qualified Public Offering or Liquidation Event, as defined in the Company’s Fourth Amended and Restated Certificate of Incorporation effective as of the date hereof. Notwithstanding anything to the contrary herein,
the terms and conditions of this Article 4 shall not apply to any Investor to the extent such Investor’s shares of Series C Preferred Stock were converted pursuant to Section 8 of Article IV of the Company’s Certificate of
Incorporation as in effect as of the date hereof. 
 4.8 Legend. Each certificate representing shares of Key Holder Stock
now or hereafter owned by the Key Holder or issued to any person in connection with a Transfer pursuant to Section 4.5 hereof shall be endorsed with the following legend: 
 “THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO, AND IN SOME CASES
PROHIBITED BY, THE TERMS AND CONDITIONS OF A CERTAIN AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT BY AND AMONG THE STOCKHOLDER, THE CORPORATION AND CERTAIN HOLDERS OF STOCK OF THE CORPORATION. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN
REQUEST TO THE SECRETARY OF THE CORPORATION.” 
 The Key Holders agree that the Company may instruct its transfer agent to
impose transfer restrictions on the shares represented by certificates bearing the legend referred to above to enforce the provisions of this Agreement and the Company agrees to promptly do so. The legend shall be removed at the request of any Key
Holder following termination of this Agreement. 
 4.9 Assignment. The rights of first refusal set forth in this
Section 4 are nonassignable without the consent of the Company, such consent which will not be unreasonably withheld, except by each Major Investor to any wholly owned subsidiary or parent of, or to any corporation, entity or other person that
is, within the meaning of the 1933 Act, controlling, controlled by or under common control with, such Major Investor or one or more affiliated partnerships, limited liability companies or funds managed by the Major Investor or any of their
respective directors, officers, partners or members; provided that such transferee agrees in writing to be subject to the terms of the investment documents as if it were a Major Investor thereunder. 
  

 22. 

 Section 5. 
 COMPANY COVENANTS 
 The Company hereby covenants and agrees on behalf of itself to
the following: 
 5.1 Affirmative Covenants. 
 (a) Financial Statements and Information for All Investors. The Company will keep books of account and prepare financial statements and will cause to be furnished to each Investor and each other
Junior Holder (all of the foregoing and following to be kept and prepared in accordance with accounting principles generally accepted in the United States applied on a consistent basis), as soon as practicable, but in any event within 160 days after
the end of each fiscal year of the Company, beginning with the fiscal year ending December 31, 2006, (1) an audited copy of the financial statements of the Company for such fiscal year containing a consolidated and consolidating balance
sheet, statement of income, statement of stockholders’ equity, and statement of cash flows, each as at the end of such fiscal year and for the period then ended and in each case setting forth in comparative form the figures for the preceding
fiscal year, all in reasonable detail and audited and certified by independent certified public accountants of recognized standing selected by the Company’s Board of Directors and (2) a comparison of the actual results during such fiscal
year to those originally budgeted by the Company for such fiscal year and a narrative description and explanation of any budget variances. 
 (b) Financial Statements and Information for Major Investors. The Company will keep books of account and prepare financial statements and will cause to be furnished to each Major Investor (all of
the foregoing and following to be kept and prepared in accordance with accounting principles generally accepted in the United States applied on a consistent basis): 
 (i) As soon as practicable after the end of each of the first three quarters of the fiscal year, but in any event within 45 days after the end of each such quarter, the unaudited consolidated balance
sheets of the Company, as of the end of such quarter, and its unaudited consolidated statements of income and losses, stockholders’ equity and cash flows for such quarter, setting forth in each case in comparative form the figures for the
corresponding period of the preceding fiscal year, all in reasonable detail (without the footnotes required under generally accepted accounting principles, and subject to year-end adjustment). Such quarterly report shall include a narrative, summary
description of the Company’s operations for such quarter, indicating whether the Company is materially in compliance with this Agreement and other material agreements and discussing any material variances from the Company’s operating plan,
accompanied by an updated forecast of financial performance for the next four quarters. 
  

 23. 

 (ii) As soon as practicable after the end of each month, but in any event within 30 days
thereafter, the unaudited consolidated balance sheet of the Company and its subsidiaries, if any, as of the end of such month and its unaudited statement of income and losses, stockholders’ equity and cash flows for such month (without the
footnotes required under generally accepted accounting principles, and subject to year-end adjustment), indicating actual results versus the Company’s plan for such month, setting forth in each case in comparative form the figures for the
corresponding period of the preceding fiscal year and a summary discussion of the Company’s principal functional areas (provided, that in alternate months the Company shall have the right to provide an interim letter regarding significant
developments in lieu of such summary discussion). 
 (iii) As soon as practicable after the adoption thereof, but in any event
within 45 days after the beginning of each fiscal year, an annual operating plan for each fiscal year, and, as soon as practicable after the adoption thereof, copies of any revisions to such annual operating plan. 
 (iv) As soon as available, a copy of each (1) financial statement, report, notice, or proxy statement sent by the Company to its
stockholders; (2) regular, periodic, or special report, registration statement, or prospectus filed by the Company with any securities exchange, state securities regulator, or the Commission; (3) material order issued by any court,
governmental authority, or arbitrator in any material proceeding to which the Company is a party or to which any of its assets is subject; (4) press release or other statement made available generally by the Company or its officers to the
public generally concerning material developments in the business of the Company; and (5) item of correspondence, report, or other information sent by the Company to any holder of any indebtedness, including, without limitation, the Investors.

 (v) Prompt notice of any default of the Company under any bond, note, indenture or other debt instrument representing
indebtedness for borrowed money and of any acceleration of indebtedness which may result therefrom. 
 (vi) With reasonable
promptness, such other information respecting the business, properties or the condition or operations, financial or other, of the Company or any subsidiary as any Holder may from time to time reasonably request. 
 (c) Inspection. The Company shall permit each Major Investor and each transferee (provided such transfer is effected in compliance
with Section 1.2 hereof), its attorney or its other representative to visit and inspect the Company’s properties, to examine the Company’s books of account and other records, to make copies or extracts therefrom and to discuss the
Company’s affairs, finances and accounts with its officers, management, employees and independent auditors all at such reasonable times and as often as such Major Investor or transferee may reasonably request; provided, however, that the
Company shall not be obligated pursuant to this Section 4.1(c) to provide trade secrets or confidential information or to provide information to any person whom the Company reasonably believes is a competitor of the Company; provided, further,
that such Major Investor shall bear any costs or expenses of such investigations or inquiries. 
  

 24. 

 (d) Observation Rights. Harbert Venture Partners, L.L.C.
(“Harbert”) shall have the right to receive notice of all meetings of the Board of Directors and to appoint one representative to attend any such meeting as a nonvoting observer, in addition to the Harbert Director (as
defined below) or any other member of the Company’s Board of Directors affiliated with Harbert. 
 (e) Payment of
Taxes. The Company shall pay, and cause each subsidiary to pay, and discharge all taxes, assessments and governmental charges or levies imposed upon it or upon its income, profits or business, or upon any properties belonging to it, prior to the
date on which penalties attach thereto, and all lawful claims that, if unpaid, might become a lien or charge upon any properties of the Company or any subsidiary, provided that neither the Company nor any subsidiary shall be required to pay
any such tax, assessment, charge, levy or claim that is being contested in good faith and by appropriate proceedings if the Company or any subsidiary shall have set aside on its books sufficient reserves, if any, with respect thereto. 
 (f) Payment of Trade Debt. The Company shall pay, and cause each subsidiary to pay, when due, or in conformity with customary trade
terms but not later than 90 days from the due date, all lease obligations, all trade debt, and all other indebtedness incident to the operations of the Company or its subsidiaries, except such as are being contested in good faith and by proper
proceedings if the Company or subsidiary concerned shall have set aside on its books sufficient reserves, if any, with respect thereto. 
 (g) Maintenance of Insurance. The Company shall maintain, and cause each subsidiary to maintain, insurance with responsible and reputable insurance companies or associations in such amounts and
covering such risks as is customarily carried by companies engaged in similar businesses and owning similar properties in the same general areas in which the Company or such subsidiary operates. The Company shall obtain and maintain in full force
and effect director and officer liability insurance in an amount and on terms and conditions acceptable to Harbert Venture Partners, L.L.C. and Intersouth Partners VI. 
 (h) Intellectual Property. The Company shall, and shall cause each subsidiary to, use its best efforts to secure, preserve and maintain all licenses and other rights to own, possess and use its
Intellectual Property (as defined in the Purchase Agreement) to the extent necessary to the conduct of its business as now conducted and as currently proposed to be conducted, provided that nothing herein shall dictate which form of protection of
Intellectual Property the Company implements. 
 (i) Compliance with Laws. The Company shall comply, and cause each
subsidiary to comply, with the requirements of all applicable laws, rules, regulations and orders of any governmental authority, noncompliance with which could materially adversely affect its Intellectual Property, business or condition (financial
or otherwise). 
  

 25. 

 (j) Records and Books of Account. The Company shall keep, and cause each subsidiary
to keep, adequate records and books of account in which complete entries will be made in accordance with accounting principles generally accepted in the United States consistently applied, reflecting all financial transactions of the Company, and in
which, for each fiscal year, all proper reserves for depreciation, depletion, returns of merchandise, obsolescence, amortization, taxes, bad debts and other purposes in connection with its business shall be made. 
 (k) Maintenance of Properties. The Company shall maintain and preserve, and cause each subsidiary to maintain and preserve, all of
its properties and assets necessary for the proper conduct of its business as now conducted and as currently contemplated to be conducted, in good repair, working order and condition, ordinary wear and tear excepted. 
 (l) ERISA Compliance. The Company shall comply, and cause each subsidiary to comply, with all minimum funding requirements applicable
to any pension, employee benefit plans, or employee contribution plans that are subject to the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), or to the Internal Revenue Code of 1986, as amended (the
“Code”), and comply, and cause each subsidiary to comply, in all other material respects with the provisions of ERISA and the Code, and the rules and regulations thereunder, which are applicable to any such plan; provided
further that neither the Company nor any subsidiary will permit any event or condition to exist that would permit any such plan to be terminated under circumstances that would cause any material lien provided for in section 4068 of ERISA to attach
to the assets of the Company or any subsidiary. 
 (m) Compliance with Environmental Laws. The Company shall comply, and
cause each subsidiary to comply, with the provisions of all federal, state and local environmental, health and safety laws, codes and ordinances and all rules and regulations promulgated thereunder, and the Company shall maintain, and cause each
subsidiary to maintain, all federal, state and local permits, licenses, certificates and approvals known to the Company or any subsidiary to be required relating to (i) air emissions, (ii) discharges to surface water or ground water,
(iii) noise emissions, (iv) solid or liquid waste disposal, (v) the use, generation, storage, transportation or disposal of toxic or hazardous substances or wastes (intended hereby and hereafter to include any and all such materials
listed in any federal, state or local law, code or ordinance and all rules and regulations promulgated thereunder, as hazardous or potentially hazardous), or (vi) other environmental, health and safety matters. 
 (n) Financings. The Company shall promptly, fully and in detail, inform the Board of Directors of any substantive discussions, offers
or contracts relating to possible financings of any nature for the Company, whether initiated by the Company or any other person, except for arrangements with trade creditors. 
 (o) Nature of Business. The Company shall continue to conduct its business without material change from the nature of the business
contemplated in the written materials delivered to the Investors prior to the date hereof, except as approved by the Board of Directors of the Company, including approval by the member of the Board of Directors designated by the holders of a
majority of Investor Stock in accordance with Section 5.1 hereto. 
  

 26. 

 (p) Nondisclosure, Invention and Noncompetition Agreements. The Company shall require
each officer of the Company and each employee who contributes to the invention, design or authorship of the Company’s proprietary technology or products to enter into the Company’s standard Nondisclosure and Inventions Agreement, in form
and substance reasonably satisfactory to the Investors, prior to the commencement of such officer’s or employee’s employment. The Company shall also require key employees designated by the Board of Directors of the Company to sign prior to
commencement of employment noncompetition agreements in form and substance satisfactory to the Board of Directors of the Company. 
 (q) Use of Proceeds. The Company shall use the proceeds from the sale of the Series C Stock for working capital purposes. 
 5.2 Negative Covenants. 
 (a) Limit on Indebtedness. The Company and
its subsidiaries shall not, directly or indirectly, create, incur, assume or be or remain liable with respect to, any indebtedness or obligation other than indebtedness (i) outstanding on the date hereof described on Schedule 5.2(a); or
(ii) arising in the ordinary course of the Company’s business that are approved by the Company’s Board of Directors. 
 (b) Limitation on Guaranties; Investments; Advances or Loans. The Company and its subsidiaries shall not guarantee, create any subsidiaries or enter into any joint ventures, or purchase or otherwise acquire, or invest in the
securities of, or make or suffer to exist any loan or advance to, or enter into any arrangement for the purpose of providing funds or credit to, or make any other investment in, any person or entity, other than as approved by the Company’s
Board of Directors and other than travel advances in the ordinary course of business. 
 (c) Sale of Assets. The Company
shall not effect any sale, lease, assignment, transfer, pledge, license, encumbrance or other conveyance of any material portion of the assets (including without limitation any technology or Intellectual Property) or operations or the revenue or
income generating capacity of the Company (other than inventory in the ordinary course of business and other assets reasonably and in good faith determined by the Company to be obsolete or no longer necessary to the business of the Company), or to
take any such action that has the effect of any of the foregoing, other than with the approval of (i) the Board of Directors and (ii) Intersouth Partners VI, L.P. and one of either Harbert or the Additional Purchaser (as defined in the
Purchase Agreement) (the “Approval Threshold”) (which approval shall be in writing). 
 (d) Employee
Compensation. The Company shall not (i) increase the compensation paid to its executive officers or directors, whether by means of salary, bonus, profit sharing, options, dividends or any other means whatsoever, or (ii) grant any
salaries and/or

  

 27. 

 
bonuses for new or existing employees of the Company in excess of $100,000, unless approved by the Board of Directors of the Company upon recommendation of the compensation committee of the
Company. 
 (e) Related Party Transactions. Without approval by a majority of the Directors who do not have an interest,
the Company shall not enter into any transaction or transactions with any director, officer or stockholder of the Company, or any affiliate or relative of the foregoing, or advance any monies to any such persons or entities, except for travel
advances in the ordinary course of business. 
 5.3 Press Release. The Company shall not issue any press release or other
information to the public regarding the financing, management, or scientific discoveries of the Company without prior written consent of the Major Investors, which consent shall not be unreasonably withheld. 
 5.4 Board Consent Required. Notwithstanding anything to the contrary in this Agreement, the Company shall not take any of the
following actions without the prior consent of the Board of Directors: 
 (a) incurrence of indebtedness in excess of $100,000;

 (b) capital expenditures in excess of $100,000 not contemplated by the Company’s Board-approved operating budget;

 (c) grant of any stock option or stock equivalent providing for vesting provisions that differ from the Company’s
standard vesting schedule or acceleration of vesting upon a change of control of the Company, sale of all or substantially all assets of the Company, termination or similar event; 
 (d) increase in the number of shares reserved under the Company’s equity incentive plans; 
 (e) creation of any committee of the Board of Directors; 
 (f) acquisition of any business (whether by stock or asset purchase, merger, consolidation or otherwise); 
 (g) changing the Company’s independent accountants; 
 (h) approval of annual
operating and capital budgets; 
 (i) entry into any material new line of business or material change to the Company’s
existing line(s) of business; 
 (j) changing the location of the Company’s executive office; 
 (k) changes by the Company of its Chief Executive Officer or other senior executive officers; 
  

 28. 

 (l) pledge or grant of security interests in any assets of the Company; 
 (m) pursue or accept any external grant funding outside of the Board-approved annual operating plan; or 
 (n) establishment or investment in any subsidiary or joint venture. 
 5.5 Expiration of Covenants; Excluded Investors. The covenants set forth in this Section 5 shall expire and be of no further
force or effect upon the effectiveness of a Qualified Public Offering (as defined in Section 2.16 hereof), Liquidation (as defined in the Restated Charter), winding up or deemed Liquidation. After such time, the Investors shall be entitled to
receive such annual and quarterly reports as the Company shall distribute to its stockholders generally. Notwithstanding anything to the contrary herein, the terms and conditions of this Article 5 shall not apply to any Investor to the extent such
Investor’s shares of Series C Preferred Stock were converted pursuant to Section 8 of Article IV of the Company’s Certificate of Incorporation as in effect as of the date hereof. 
 Section 6.  
 VOTING AGREEMENT 
 6.1 Election of Directors. The Board of Directors of the Company will consist of
five persons. The Preferred Holders and Common Holders shall, whether by meeting, action by written consent of lieu of a meeting, or otherwise, act in all capacities and vote the shares of capital stock of the Company now or hereafter owned or
controlled by them so as to cause and maintain the election to the Board of Directors of the Company of (a) two representatives of the holders of a majority of Common Stock held by the Common Holders, one of which shall be the chief executive
officer of the Company (“CEO”), who shall initially be Tom Amick as the CEO, and the other shall be an individual not affiliated with the Company or any Investor, who shall initially be Russ Medford, (b) one designee of
Harbert (the “Harbert Director”), who shall initially be William Brooke, (c) one designee of Intersouth Partners VI, L.P. (the “Intersouth Director”), who shall initially be Garheng Kong and
(d) one designee nominated by a majority of the Common Holders and the Junior Holders, voting together as a single class, who shall initially be B. Jefferson Clark. Harbert, Intersouth Partners VI, the Junior Holders or the Common Holders may
elect at any time to replace their designee on the Board of Directors, in which case all parties will vote to remove their then-current designee(s) and elect new designee(s) of that voting group. Upon request, the Harbert Director and Intersouth
Director shall be appointed to any committee of the Board of Directors. 
 6.2 Binding Effect of Voting Agreement. The
voting agreement set forth in this Section 6 shall be binding upon any transferee of shares of the Company’s stock held by the Preferred Holders and Common Holders. Each such transferee shall execute documents assuming the obligations of
the transferor under this Section 6 prior to the completion of such transfer. 
  

 29. 

 6.3 Legends. Each certificate held by or issued to the Investors or the Common
Holders, whether now outstanding or subsequently issued, shall be surrendered to the Company for endorsement or be endorsed by the Company prior to its issuance with substantially the following legend. 
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO AN INVESTOR RIGHTS AGREEMENT, AMONG THE ISSUER, THE HOLDER OF THESE SECURITIES,
AND CERTAIN OTHER HOLDERS OF THE ISSUER’S SECURITIES. BY ACCEPTING ANY INTEREST IN SUCH SECURITIES, THE PERSON ACCEPTING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL OF THE PROVISIONS OF SUCH AGREEMENT. COPIES OF SUCH
INVESTOR RIGHTS AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF THE CORPORATION AT THE PRINCIPAL EXECUTIVE OFFICES OF THE CORPORATION. 
 6.4 Drag-Along Rights. In the event that holders of Series C Preferred Stock representing the Approval Threshold (the
“Requisite Investors”) approve either (i) a future financing transaction (“Approved Financing”) or (ii) a sale of the Company or all or substantially all of the Company’s assets whether
by means of a merger, consolidation or sale of stock or assets, or otherwise (an “Approved Sale”, and together with an Approved Financing, an “Approved Transaction”), then (i) in the case of an
Approved Financing, each Series C Holder and Key Holder agrees to be present, in person or by proxy, at all meetings for the vote thereon, to vote all shares of capital stock held by such person for and raise no objections to such Approved
Financing, (ii) in the event of an Approved Sale that is structured as a merger or consolidation of the Company, or a sale of all or substantially all of the Company’s assets, each Series C Holder and Key Holder agrees to be present, in
person or by proxy, at all meetings for the vote thereon, to vote all shares of capital stock held by such person for and raise no objections to such Approved Sale, and waive and refrain from exercising any dissenters rights, appraisal rights or
similar rights in connection with such merger, consolidation or asset sale, or (ii) in the case of an Approved Sale that is structured as a sale of the stock of the Company, each Series C Holder and Key Holder shall agree to sell their
Preferred Stock and Common Stock, including any stock issued upon conversion of the Preferred Stock, on the terms and conditions approved by the Requisite Investors; provided in each case that such terms do not provide that such Series C Holders and
Key Holders would receive as a result of such Approved Sale less than the amount that would be distributed to such holders in the event the proceeds of such Approved Sale of the Company were distributed in accordance with the liquidation preferences
set forth in Company’s Restated Charter, as amended. The Series C Holders and Key Holders shall each take all necessary and desirable actions approved by the Requisite Investors in connection with the consummation of an Approved Transaction,
including the execution of such agreements and such instruments and other actions reasonably necessary to (i) provide the representations, warranties, indemnities, covenants, conditions, non-compete agreements, escrow agreements and other
provisions and agreements relating to such Approved Transaction and (ii) effectuate the allocation and distribution of the aggregate consideration upon the Approved Transaction. 
  

 30. 

 6.5 Irrevocable Proxy. To secure the Series C Holders’ and Key Holders’
obligations to vote their respective shares in accordance with this Agreement, each Series C Holder and Key Holder hereby appoints the Harbert Director of the Company, or his designees, as such Series C Holder’s and Key Holder’s true
and lawful proxy and attorney, with the power to act alone and with full power of substitution, to vote all of such Series C Holder’s and Key Holder’s Preferred Stock and Common Stock as set forth in this Agreement and to execute all
appropriate instruments consistent with this Agreement on behalf of such Series C Holder and Key Holder if, and only if, such Series C Holder and Key Holder fails to vote all of such Series C Holder’s or Key Holder’s Preferred Stock
or Common Stock or execute such other instruments in accordance with the provisions of this Agreement within five (5) days of the Company’s or any other party’s written request for such Series C Holders’ or Key Holders’
written consent or signature. The proxy and power granted by each Series C Holder and Key Holder pursuant to this Section are coupled with an interest and are given to secure the performance of such party’s duties under this Agreement. Each
such proxy and power will be irrevocable for the term hereof. The proxy and power, so long as any party hereto is an individual, will survive the death, incompetency and disability of such party or any other individual holder of the Preferred Stock
and Common Stock and, so long as any party hereto is an entity, will survive the merger or reorganization of such party or any other entity holding any Preferred Stock or Common Stock. 
 6.6 Termination of Voting Agreement. The covenants set forth in this Section 6 shall terminate upon the earliest of (a) the
closing of a Qualified Public Offering (as defined in Section 2.16 hereof), (b) such time as the Company shall be subject to the reporting requirements arising under the 1934 Act, or any successor statute and any applicable rules
promulgated thereunder by the SEC or (c) the date 10 years from the date hereof. 
 Section 7.  
 MISCELLANEOUS 
 7.1 Governing Law. This Agreement shall be governed by, and construed and interpreted in accordance with the laws of the State of Delaware as applied to agreements between Delaware residents made and to be performed entirely within
the State of Delaware. 
 7.2 Successors and Assigns. Except as otherwise expressly provided herein, the provisions
hereof shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. 
 7.3 Entire Agreement; Amendment and Restatement of Prior Investor Rights Agreement; Termination of Stock Sale Agreement. The Prior Investor Rights Agreement is hereby amended in its entirety and
restated therein. Such amendment and restatement is effective upon the execution of this Agreement by the Requisite Approval. The Stock Sale Agreement is hereby terminated upon execution of this Agreement by the Requisite Stock Sale Approval and
upon execution of this Agreement shall no longer be in force and effect. This Agreement constitutes the full and entire understanding and agreement among the parties with regard to the subjects hereof and supersedes all prior agreements and
understandings between them or any of them as to such subject matter. Nothing in this Agreement, express or implied, is intended to confer upon any party, other than the parties hereto and their successors and assigns, any rights, remedies,
obligations or liabilities under or by reason of this Agreement, except as expressly provided herein. 
  

 31. 

 7.4 Severability. Any invalidity, illegality or limitation of the enforceability with
respect to any Holder of any one or more of the provisions of this Agreement, or any part thereof, whether arising by reason of the law of any such person’s domicile or otherwise, shall in no way affect or impair the validity, legality or
enforceability of this Agreement with respect to any other Holder. In case any provision of this Agreement shall be invalid, illegal or unenforceable, it shall to the extent practicable, be modified so as to make it valid, legal and enforceable and
to retain as nearly as practicable the intent of the parties, and the validity, legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 7.5 Amendment and Waiver. Except as otherwise expressly provided herein, any term of this Agreement may be amended and the observance
of any term of this Agreement may be waived (either generally or in a particular instance, either retroactively or prospectively and either for a specified period of time or indefinitely) with the written consent of (i) the Company,
(ii) the Junior Holders, or their transferees, holding at least 66-2/3% of the shares of Junior Preferred and voting together as a single group (treated as if converted at the conversion rate then in effect and including, for such purposes,
shares of Common Stock into which any shares of Junior Preferred shall have been converted that are held by a Junior Holder), (iii) the Series C Holders, or their transferees, representing the Approval Threshold; provided,
however, that (a) no such amendment or waiver shall reduce the aforesaid percentage of Preferred Stock and Common Stock issued upon conversion thereof, the holders of which are required to consent to any waiver or supplemental agreement,
without the consent of the holders of all of such Preferred Stock and Common Stock, (b) any amendment to Section 2.15 (or to Section 2.3 that would affect the rights under 2.15) or to Section 6 shall also require the consent of
the holders of at least a majority of the Common Stock held by the Common Holders, and (c) any amendment to Section 4 shall also require the consent of a majority of the Key Holders. Any amendment or waiver effected in accordance with this
Section 7.5 shall be binding upon each Common Holder, each Investor and each transferee of the Registrable Securities. Upon the effectuation of each such amendment or waiver, the Company shall promptly give written notice thereof to the
Investors and Common Holders who have not previously consented thereto in writing. Notwithstanding anything to the contrary in this Section 7.5, the Company shall be entitled to include additional purchasers of its Series C Stock pursuant to
the Purchase Agreement as parties to this Agreement, and to treat such purchasers as “Investors” and “Holders” hereunder, by amending Exhibit A attached hereto and providing such Exhibit A, as amended, to the other
parties to this Agreement. 
 7.6 Delays or Omissions. No delay or omission to exercise any right, power or remedy
accruing to the Company, the Investors, or any transferees upon any breach, default or noncompliance of the Investors or any transferee or the Company under this Agreement, shall impair any such right, power or remedy, nor shall it be construed to
be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent or approval of any kind or
character on the part of the Company or the Investors of any breach, default or noncompliance under this Agreement or any waiver on the Company’s or the

  

 32. 

 
Investors’ part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing and that all remedies,
either under this Agreement, by law, or otherwise afforded to the Company and the Investors, shall be cumulative and not alternative. 
 7.7 Notices, etc. All notices and other communications required or permitted under this Agreement shall be given in writing and shall be deemed effectively given upon personal delivery or upon deposit with the United States Post
Office, by registered or certified mail, postage prepaid, or sent by confirmed telecopy or confirmed electronic mail, addressed: 
 (a) if to the Company, to: 
 Aldagen, Inc. 
 2810 Meridian Parkway, Suite 148 
 Durham, NC 27713 
 Attn: Edward L. Field 
 Telephone:    (919)
484-2571 
 Telecopier:    (919) 484-8792 
 With a copy to: 
 Hutchison Law Group PLLC 
 5410 Trinity Road 
 Suite 400 
 Raleigh, NC 27607 
 Attn: Fred D. Hutchison, Esq. 
 Telephone:    (919) 829-9600 
 Telecopier:    (919) 829-9696 
 or to such other address as the Company shall have furnished to the Preferred Holders in writing; 
 (b) if to the Investors, at the addresses of such Investors specified on Exhibit A hereto, or at such other addresses as the Investors shall have furnished to the Company in writing, with a copy
to: 
 Cooley Godward Kronish, L.L.P. 
 One Freedom Square 
 11951 Freedom Drive 
 Reston, VA 20190 
 Attn: Christian Plaza, Esq. 
 Telephone:    (703) 456-8006 
 Telecopier:    (703) 456-8100 
 (c) if to a Holder other than the Investors, at such Holder’s
address as shall have been furnished to the Company in writing; and 
  

 33. 

 (d) if to the Common Holders, at the addresses of such Common Holders specified on
Exhibit C hereto, or at such other addresses as the Common Holders shall have furnished to the Company in writing. 
 7.8
Titles and Subtitles. The titles of the sections and subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
 7.9 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of
which together shall constitute one instrument. 
 [REMAINDER OF PAGE LEFT BLANK INTENTIONALLY] 
  

 34. 

 IN WITNESS WHEREOF, this Investor Rights Agreement has been duly executed and delivered by
the parties as of the date first above written. 
  

					
	COMPANY:	 	ALDAGEN, INC.
			
		 	By:	 	 /s/ Edward L. Field

		 	Name:	 	Edward L. Field
		 	Title:	 	President
		
	INVESTORS:	 	HARBERT VENTURE PARTNERS, L.L.C.
			
		 	By:	 	Harbert Venture Partners MM, LLC
		 	Its:	 	Managing Member
			
		 	By:	 	HMC Virginia, Inc.
		 	Its:	 	Manager
			
		 	By:	 	 /s/ William W. Brooke

		 	Name:	 	William W. Brooke
		 	Title:	 	Executive Vice President
		
		 	INTERSOUTH PARTNERS VI, L.P.
			
		 	By:	 	INTERSOUTH ASSOCIATES VI, LLC
		 	Its	 	General Partner
			
		 	By:	 	 /s/ Mitch Mumma

		 	Name:	 	Mitch Mumma
		 	Title:	 	Member Manager
		
		 	INTERSOUTH PARTNERS V, L.P.
			
		 	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its	 	General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, acting pursuant to Power of Attorney
		
		 	INTERSOUTH AFFILIATES V, L.P.
			
		 	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its	 	General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, acting pursuant to Power of Attorney

			
	INTERSOUTH PARTNERS VII, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VII, LLC
	Its	 	General Partner
		
	By:	 	 /s/ Garheng Kong

	Name:	 	Garheng Kong
	Title:	 	Member, acting pursuant to Power of Attorney
	
	THE AUGUST JACKSON COMPANY
		
	By:	 	 /s/ Frank Andrews

	Name:	 	Frank Andrews
	Title:	 	President and CEO
	
	AURORA ENRICHMENT FUND, LLC
		
	By:	 	Aurora Enrichment Management Co., LLC
	Its	 	Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

	Name:	 	B. Jefferson Clark
	Title:	 	Manager
	
	HARBINGER/AURORA VENTURE FUND, L.L.C.
		
	By:	 	Harbinger/Aurora Ventures, LLC
	Its	 	Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

	Name:	 	B. Jefferson Clark
	Title:	 	President
	
	HARBINGER/AURORA QP VENTURE FUND, L.L.C.
		
	By:	 	Harbinger/Aurora Ventures, LLC
	Its	 	Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

	Name:	 	B. Jefferson Clark
	Title:	 	President
	
	 /s/ W. Lowry Caudill

	W. Lowry Caudill

			
	 /s/ Alfred G. Childers

	Alfred G. Childers
	
	 /s/ Jonathon M. Lawrie

	Jonathon M. Lawrie
	
	PIEDMONT ANGEL NETWORK LLC
		
	By:	 	 /s/ W.B. Rodman Davis

	Name:	 	W. B. Rodman Davis
	Title:	 	Managing Member
	
	TALL OAKS STEMCO PARTNERS, LP
		
	By:	 	 /s/ Kathryne F. Carr

	Name:	 	Kathryne F. Carr
	Title:	 	Managing Director, TOCP, LLC as General Partner
	
	THE TRELYS FUNDS, L.P.
		
	By:	 	 /s/ Adrian N. Wilson

	Name:	 	Adrian N. Wilson
	Title:	 	Managing General Partner
	
	VILLAGE VENTURES PARTNERS FUND, L.P.
		
	By:	 	 Village Ventures Capital Partners I, LLC,
 its general partner

	By:	 	Village Ventures, Inc., its manager
		
	By:	 	 /s/ Steven H. Massicotte

	Name:	 	Steven H. Massicotte
	Title:	 	Chief Operating Officer
	
	VILLAGE VENTURES PARTNERS FUND A, L.P.
		
	By:	 	 Village Ventures Capital Partners I, LLC,
 its general partner

	By:	 	Village Ventures, Inc., its manager
		
	By:	 	 /s/ Steven H. Massicotte

	Name:	 	Steven H. Massicotte
	Title:	 	Chief Operating Officer

			
	CNF INVESTMENTS II, LLC
		
	By:	 	 /s/ Robert J. Flanagan

	Name:	 	Robert J. Flanagan
	Title:	 	Manager
	
	NEW MARKETS GROWTH FUND
		
	By:	 	 /s/ Mark Grovic

	Name:	 	Mark Grovic
	Title:	 	Managing Director
	
	TULLIS-DICKERSON CAPITAL FOCUS III, L.P.
		
	By:	 	Tullis-Dickerson Partners III, L.L.C.
	Its	 	General Partner
		
	By:	 	 /s/ Lyle A. Hohnke

	Name:	 	Lyle A. Hohnke
	Title:	 	Partner

					
	COMMON HOLDERS:	 	 /s/ Clay Smith
	 	(SEAL)
		 	Clay Smith, M.D.	 	
			
		 	 /s/ Nelson Chao
	 	(SEAL)
		 	Nelson Chao, M.D.	 	
			
		 	 /s/ Michael Colvin
	 	(SEAL)
		 	Michael Colvin, M.D.	 	
			
		 	 /s/ Jonathon M. Lawrie
	 	(SEAL)
		 	Jonathon M. Lawrie	 	
			
		 	 /s/ Andrew Balber
	 	(SEAL)
		 	Andrew Balber	 	

 EXHIBIT A 
 SCHEDULE OF INVESTORS 
 Harbert Venture Partners, L.L.C. 

Intersouth Partners VI, L.P. 
 Intersouth
Affiliates V, L.P. 
 Intersouth Partners V, L.P. 
 Intersouth Partners VII, L.P. 
 The August Jackson Company 
 Harbinger/Aurora Venture Fund, L.L.C. 
 Harbinger/Aurora QP Venture Fund, L.L.C. 
 W. Lowry Caudill 
 Alfred G. Childers 
 Jonathon M. Lawrie 
 Tall Oaks StemCo Partners, LP 
 The Trelys Funds,
L.P. 
 Village Ventures Partners Fund, L.P. 
 Village Ventures Partners Fund A, L.P. 
 CNF Investments II, LLC 
 Tullis-Dickerson Capital Focus III, L.P. 
 New Markets Growth Fund 

 EXHIBIT B 
 SCHEDULE OF SERIES A HOLDERS AND SERIES B HOLDERS 
 Intersouth
Partners, V, L.P. 
 Intersouth Affiliates V, L.P. 
 Harbinger/Aurora Venture Fund, LLC 
 Harbinger/Aurora QP Venture Fund, LLC 
 Aurora Enrichment Fund, LLC 
 The Trelys Funds, L.P.

 W. Lowry Caudill 
 Piedmont Angel
Network 
 Alfred G. Childers 
 Tall
Oaks StemCo Partners, LP 
 Village Ventures Partners Fund, L.P. 
 Village Ventures Partners Fund A, L.P. 

 EXHIBIT C 
 SCHEDULE OF COMMON HOLDERS 
 Clay Smith 
 Nelson Chao 
 Michael Colvin 
 Jonathon Lawrie 
 Andrew Balber 
 H&M Holdings LLC 
 BD Ventures, LLC

 FIRST AMENDMENT TO SERIES C PREFERRED STOCK PURCHASE 
 AGREEMENT AND AGREEMENT TO PURCHASE SHARES AND JOIN AS A PARTY 
 AND 
 FIRST AMENDMENT TO AMENDED AND RESTATED
INVESTOR RIGHTS 
 AGREEMENT 
 This First Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a Party and First Amendment to Amended and Restated Investor Rights Agreement (this
“Agreement”) dated as of September 12, 2007 by and among Aldagen, Inc., a Delaware corporation (the “Company”), each of those persons and entities that previously purchased shares of the Series C Preferred
Stock of the Company (the “Series C Preferred”) pursuant to the Purchase Agreement (defined below) and whose names are set forth on EXHIBIT A hereto as “Purchasers” (each, a “Purchaser”
and collectively, the “Purchasers”), and each of those entities that propose to purchase shares of the Series C Preferred pursuant hereto and whose names are set forth on EXHIBIT A hereto as
“Additional Purchasers” (each, an “Additional Purchaser” and together, the “Additional Purchasers”). 
 WITNESSETH: 
 WHEREAS, the Company, the Purchasers and other investors have
entered into a Series C Preferred Stock Purchase Agreement dated December 15, 2006 (the “Purchase Agreement”), and the Company and certain holders of capital stock of the Company have entered into an Amended and Restated
Investor Rights Agreement dated December 15, 2006 (the “Rights Agreement”, and together with the Purchase Agreement, the “Agreements”); 
 WHEREAS, the Additional Purchasers and the Purchasers propose to purchase shares of the Series C Preferred and Series C-l Preferred Stock
(as defined below) pursuant to the terms and conditions of the Purchase Agreement, as amended hereby; 
 WHEREAS,
Section 2.3 of the Purchase Agreement provides that the purchase of the Series C Preferred may be made by additional purchasers pursuant to one or more closings occurring on or before September 11, 2007, and Section 7.5 of the Rights
Agreement provides that an additional purchaser of the Series C Preferred shall become a party to the Rights Agreement; 
 WHEREAS, the Company desires to issue, and the Purchasers and the Additional Purchasers each desire to purchase, subject to the terms and conditions of the Purchase Agreement (as amended hereby), approximately $7.0 million of Series C
Preferred as set forth under “Shares Purchased at Additional Closing” on EXHIBIT A to the Purchase Agreement (as amended hereby); 
 WHEREAS, the Additional Purchasers have agreed to be bound by the terms of the Agreements and to become parties to the Agreements, as amended as set forth herein; 
  

 1 

 WHEREAS, the Company, the Purchasers and the Additional Purchasers each desire to amend the
Purchase Agreement by amending Section 2.3 in certain respects and by amending Section 2.4 of the Purchase Agreement in certain respects and by deleting all references therein to the Second Closing and, in lieu of the Second Closing, each
hereby agrees to enter into a proposed private placement of up to $6,058,654.41 of shares of the Series C-l Preferred Stock of the Company (the “Series C-1 Preferred Stock”) upon the terms set forth herein (the “Series C-1
Financing”); and 
 WHEREAS, the Company, the Purchasers and the Additional Purchasers each desire to amend certain
provisions of the Rights Agreement as set forth herein; 
 NOW, THEREFORE, in consideration of the premises, the covenants of
the parties set forth below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 1. Capitalized Terms. Terms that are used herein with initial capital letters and that are not otherwise defined shall have the meanings given to them in the Purchase Agreement. 
 2. The Purchase Agreement. 
 2.1 Section 2.3 of the Purchase Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 
 “2.3 Subsequent Sales of Shares. Harbert Venture Partners, L.L.C. (“Harbert”) agrees to
assist the Company in identifying one or more potential additional purchasers mutually acceptable to the Company and Harbert (the “Additional Purchasers”). At any time on or before the 90th day following the First Closing or at such later time as Harbert and
Intersouth Partners VI, L.P. (“Intersouth VI”) unanimously agree, but in no event later than 300 days from the First Closing, the Company may sell up to $5,000,000 of the Shares at the purchase price set forth in Section 1.2
above to the Additional Purchasers and up to $2,000,000 of the Shares at the purchase price set forth in Section 1.2 above to Harbert and to Intersouth VI, Intersouth Partners V, L.P. and Intersouth Affiliates V, L.P. (collectively,
“Intersouth”). Such sale made at an additional closing (the “Additional Closing”) shall be made on the terms and conditions set forth in this Agreement, and (i) the representations and warranties of the Company
set forth in Section 3 hereof shall speak as of the Additional Closing and the Company shall update the Schedule of Exceptions as of the Additional Closing, and (ii) the representations and warranties of the Additional Purchasers, Harbert
and Intersouth in Section 4 hereof shall speak as of the Additional Closing. The Schedule of Purchasers may be amended by the Company without the consent of the Purchasers to include the Additional Purchasers and the shares being purchased by
the Additional Purchasers in this Additional Closing upon the execution by the Additional Purchasers of counterpart signature pages hereto. Any shares of Series C Preferred Stock sold pursuant to this Section 2.3 shall be deemed to be
“Shares” for all purposes under this Agreement and the Additional Purchasers thereof shall be deemed to be “Purchasers” for all purposes under this Agreement.” 
  

 2 

 2.2 Section 2.4 of the Purchase Agreement shall be deleted in its entirety and
the following substituted in lieu thereof: 
 “2.4 Series C-1 Closing. In the event the Company’s Board of
Directors (the “Board”) in good faith determines that the Company has achieved the Milestones (as defined below), the Company shall deliver a notice to each of the Purchasers and Additional Purchasers with shares listed opposite
their names on EXHIBIT A under the heading “Shares Purchased at Series C-l Closing” (collectively “C-1 Purchasers”) advising the C-l Purchasers of the Board’s determination. Within 10 days after
the Board delivers such notice to such C-l Purchasers, Intersouth VI and at least two of either Harbert, Tullis-Dickerson Capital Focus III, L.P. (“T-D”) or CNF Investments II, LLC (“CNF”) shall decide whether they
concur with the Board’s determination that the Milestones have been achieved. In the event Intersouth VI and at least two of either Harbert, T-D or CNF agree in writing (each in their sole discretion) that the Milestones have been achieved
(“Milestone Approval”), the Company shall sell Series C-l Preferred Stock to the C-l Purchasers in the amounts set forth in the Schedule of Purchasers attached hereto as EXHIBIT A under the heading “Shares
Purchased at Series C-l Closing” at a purchase price of $1.0411 per share and subject to adjustment as set forth in the Restated Certificate (as defined below). The Series C-l Preferred Stock shall have the rights and preferences set forth in
the Fifth Amended and Restated Certificate of Incorporation of the Company attached hereto as EXHIBIT C (“Restated Certificate”). Within 30 days of notice to the C-l Purchasers by the Company of such Milestone
Approval and satisfaction of the conditions set forth in Section 5.3 below (such date, the “Series C-1 Closing Date”), all C-l Purchasers shall participate in the Series C-l Preferred Stock closing (“Series C-1
Closing”) to the full extent of their obligation to purchase shares in the Series C-1 Closing in the amount set forth adjacent to their names under the heading “Shares Purchased at Series C-l Closing” on EXHIBIT
A (“Pro Rata Amount”). Any shares of Series C-l Preferred Stock sold pursuant to this Section 2.4 shall be deemed to be “Shares” for all purposes of this Agreement with respect to the Series C-l Closing and
any C-l Purchasers shall be deemed “Purchasers” for all purposes of this Agreement with respect to the Series C-l Closing. For purposes of this Agreement, “Milestones: shall mean, collectively, (i) the initiation by
the Company of a Pivotal Trial (as defined below) in cord blood transplant; or (ii) the successful completion of a Phase I clinical trial in cardiovascular or peripheral vascular disease. “Pivotal Trial” means a clinical trial
that is of appropriate size and design to establish that a product is safe and effective for its intended use, to define warnings, precautions and adverse reactions that are associated with the product, and to support marketing approval for such
product by the United States Food and Drug Administration. Notwithstanding anything to the contrary in this Agreement, at any time on or before December 3, 2008, each C-l Purchaser shall have the right, but not the obligation, to purchase their
Pro Rata Amount even if the Milestones have not been achieved. 
 If the conditions set forth in Section 5.2 below have been
satisfied and any C-l Purchaser does not acquire shares of Series C-l Preferred Stock at the Series C-l

  

 3 

 
Closing in an amount equal to or greater than its allotted amount as shown under the heading “Shares Purchased at Series C-1 Closing” on EXHIBIT A hereto (a
“Nonparticipating Holder”), then all of the shares of Preferred Stock held by such Nonparticipating Holder shall automatically and without further action on the part of such holder be converted (the “Special Mandatory
Conversion”) into shares of Common Stock as specified in Section B.8 of Article IV of the Restated Charter.” 
 2.3 The Company has made available to each Additional Purchaser (a) its audited balance sheet as at December 31, 2006 and audited statement of income and cash flows for the twelve months ending December 31, 2006, and
(b) its balance sheet as of June 30, 2007 and consolidated statement of income and cash flows for the six-month period ending on June 30, 2007. For purposes of the Additional Closing, the term “Statement Date” shall mean
June 30, 2007, and “Financial Statements” shall mean the audited and unaudited balance sheets, statements of income and cash flows described in this paragraph. 
 2.4 Section 5.2 of the Purchase Agreement shall be deleted in its entirety and the following substituted in lieu thereof:

 “5.2 Conditions to Additional Purchasers’ Obligations at the Additional Closing. Additional
Purchasers’ obligations to purchase Shares at the Additional Closing are subject to the satisfaction, at or prior to the Additional Closing Date, of the following conditions: 
 (a) Representation and Warranties True; Performance of Obligations. The representations and warranties made by the
Company in Section 3 hereof shall be true and correct as of the Additional Closing Date with the same force and effect as if they had been made as of the Additional Closing Date and the Company shall have performed all obligations and
conditions herein required to be performed or observed by it on or prior to the Additional Closing. 
 (b)
Legal Investment. On the Additional Closing Date, the sale and issuance of the Shares and the proposed issuance of the Conversion Shares shall be legally permitted by all laws and regulations to which the Additional Purchasers and the Company
are subject. 
 (c) Consents, Permits, and Waivers. The Company shall have obtained any and all consents,
permits and waivers necessary or appropriate for consummation of the transactions contemplated by the Agreement and the Related Agreements (including any filing required to comply with the Hart Scott Rodino Antitrust Improvements Act of 1976) except
for such as may be properly obtained subsequent to the Additional Closing. 
 (d) Filing of Restated Charter.
The Restated Certificate shall have been filed with the Secretary of State of the State of Delaware and shall continue to be in full force and effect as of the Additional Closing Date. 
  

 4 

 (e) Corporate Documents. The Company shall have delivered to the
Additional Purchasers or their counsel copies of all corporate documents of the Company as the Additional Purchasers shall reasonably request. 
 (f) Reservation of Conversion Shares. The Conversion Shares issuable upon conversion of the Series C Preferred Stock shall have been duly authorized and reserved for issuance upon such conversion.

 (g) Compliance Certificate. The Company shall have delivered to Additional Purchasers a Compliance
Certificate, executed by the President of the Company, dated the Additional Closing Date, to the effect that the conditions specified in subsections (a), (c), (d), (e) and (f) of this Section 5.2 have been satisfied. 
 (h) Assistant Secretary’s Certificate. Additional Purchasers shall have received from the Company’s
Secretary, a certificate having attached thereto (i) the Company’s Restated Certificate as in effect at the time of the Additional Closing, (ii) the Company’s Bylaws as in effect at the time of the Additional Closing,
(iii) resolutions approved by the Board of Directors authorizing the transactions contemplated hereby, (iv) resolutions approved by the Company’s stockholders authorizing the filing of the Restated Certificate and, as necessary, the
transactions contemplated hereby, and (v) good standing certificates (including tax good standing if available) with respect to the Company from the applicable tax authority(ies) in Delaware, North Carolina and any other jurisdiction in which
the Company is qualified to do business, dated a recent date before the Additional Closing. 
 (i) Legal
Opinion. The Additional Purchasers shall have received from legal counsel to the Company an opinion addressed to them, dated as of the Additional Closing Date, in substantially the form attached hereto as EXHIBIT I.

 (j) Proceedings and Documents. All corporate and other proceedings in connection with the transactions
contemplated at the Additional Closing hereby and all documents and instruments incident to such transactions shall be reasonably satisfactory in substance and form to the Additional Purchasers and their special counsel, and the Additional
Purchasers and their special counsel shall have received all such counterpart originals or certified or other copies of such documents as they may reasonably request. 
 (k) Management Rights. A Management Rights letter substantially in the form attached hereto as Exhibit J shall
have been executed by the Company and delivered to each Additional Purchaser to whom it is addressed. 
 (l)
Fees of Additional Purchaser’s Counsel and Consultants. The Company shall have paid the fees, expenses and disbursements of legal counsel incurred with respect to the purchase of the Shares as set forth in Section 6.9.”

  

 5 

 2.5 A new Section 5.3 of the Purchase Agreement shall be added as follows, and
Section 5.3 renumbered Section 5.4: 
 “5.3 Conditions to C-1 Purchasers’ Obligations at the Series C-1
Closing. C-1 Purchasers’ obligations to purchase Shares at the Series C-1 Closing are subject to the satisfaction, at or prior to the Series C-1 Closing Date, of the following conditions: 
 (a) Representation and Warranties True; Performance of Obligations. The representations and warranties made by the
Company in Section 3 hereof shall be true and correct as of the Series C-1 Closing Date with the same force and effect as if they had been made as of the Series C-1 Closing Date and the Company shall have performed all obligations and
conditions herein required to be performed or observed by it on or prior to the Series C-1 Closing. 
 (b)
Legal Investment. On the Series C-1 Closing Date, the sale and issuance of the Series C-1 Preferred Stock and the proposed issuance of the Common Stock into which the Series C-1 Preferred Stock is convertible (the “Series C-1
Conversion Shares”) shall be legally permitted by all laws and regulations to which the C-1 Purchasers and the Company are subject. 
 (c) Consents, Permits, and Waivers. The Company shall have obtained any and all consents, permits and waivers necessary or appropriate for consummation of the transactions contemplated by the
Agreement and the Related Agreements (including any filing required to comply with the Hart Scott Rodino Antitrust Improvements Act of 1976) except for such as may be properly obtained subsequent to the Series C-1 Closing. 
 (d) Corporate Documents. The Company shall have delivered to the C-1 Purchasers or their counsel copies of all
corporate documents of the Company as the C-1 Purchasers shall reasonably request. 
 (e) Reservation of
Conversion Shares. The Series C-1 Conversion Shares issuable upon conversion of the Series C-1 Preferred Stock shall have been duly authorized and reserved for issuance upon such conversion. 
 (f) Legal Opinion. The C-1 Purchasers shall have received from legal counsel to the Company an opinion addressed to
them, dated as of the Series C-1 Closing Date, in substantially the form attached hereto as EXHIBIT I. 
 (g) Proceedings and Documents. All corporate and other proceedings in connection with the transactions contemplated at the Series C-1 Closing hereby and all documents and instruments incident to
such transactions shall be reasonably satisfactory in substance and form to the C-1 Purchasers and their special counsel, and the C-1 Purchasers and their special counsel shall have received all such counterpart originals or certified or other
copies of such documents as they may reasonably request. 
  

 6 

 (h) Fees of Purchaser’s Counsel and Consultants. The Company
shall have paid, in accordance with Section 6.9, the fees, expenses and disbursements of counsel and consultants to the C-1 Purchasers. 
 (i) Achievement of Milestones. The Company shall have achieved the Milestones as determined in accordance with Section 2.4.” 
 2.6 Section 6.6 of the Purchase Agreement shall be deleted in its entirety and the following substituted in lieu thereof:

 “6.6 Amendment and Waiver. Except as otherwise expressly provided for in Section 2.3, this
Agreement may be amended or modified, and the obligations of the Company and the rights of the holders of the Shares and the Conversion Shares under the Agreement may be waived, only upon the written consent of the (i) Company,
(ii) Intersouth Partners VI, L.P. and (iii) at least two of Harbert, T-D and CNF.” 
 2.7 Section 6.9
of the Purchase Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 
 “6.9 Expenses. Each party shall pay all costs and expenses that it incurs with respect to the negotiation, execution, delivery and performance of the Agreement; provided, however, that the Company shall, at each of the
Additional Closings and the Series C-1 Closing, reimburse the reasonable fees of and expenses of legal counsel to T-D in an amount not to exceed $55,000 in the aggregate for all such Closings and the reasonable fees of and expenses of legal counsel
of Harbert not to exceed $65,000 in the aggregate for all Closings.” 
 2.8 Sale of Shares to Additional Purchasers.
The Additional Purchasers and the Purchasers each hereby agree to purchase the number of shares of the Series C Preferred set forth opposite its name on EXHIBIT A attached hereto and shall transmit to the Company, in
accordance with the relevant provisions of the Purchase Agreement, the amount set forth opposite its name on such EXHIBIT A in payment for the shares of the Series C Preferred being purchased by such Additional
Purchasers and such Purchasers on the date hereof. 
  

	 	3.	The Rights Agreement 

 3.1
Section 3.5 of the Rights Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 
 “3.5 Expiration of Right. The right of first offer granted under this Section 3 shall not apply to, and shall expire upon, the effectiveness of a registration statement for a Qualified
Public Offering or a Liquidating Event, as defined in the Company’s Fifth Amended and Restated Certificate of Incorporation effective as of the date hereof.” 
  

 7 

 3.2 Section 4.1(b) of the Rights Agreement shall be deleted in its entirety and the
following substituted in lieu thereof: 
 “(b) “Key Holder Stock” shall mean shares
of the Company’s Common Stock or Junior Stock now owned or subsequently acquired by the Key Holders by gift, purchase, dividend, option exercise or any other means whether or not such securities are only registered in a Key Holder’s name
or beneficially or legally owned by such Key Holder, including any interest of a spouse in any of the Key Holder Stock, whether that interest is asserted pursuant to marital property laws or otherwise. The number of shares of Key Holder Stock owned
by the Key Holders as of the date hereof are set forth on Exhibit A and Exhibit B, which Exhibits may be amended from time to time by the Company to reflect changes in the number of shares owned by the Key Holders, but the failure to so amend shall
have no effect on such Key Holder Stock being subject to this Agreement.” 
 3.3 Section 4.7 of the Rights Agreement
shall be deleted in its entirety and the following substituted in lieu thereof: 
 “4.7 Expiration of
Right; Excluded Investors. The right of first refusal and right of co-sale granted under this Section 4 shall not apply to, and shall expire upon, the effectiveness of a registration statement for a Qualified Public Offering or Liquidation
Event, as defined in the Company’s Fifth Amended and Restated Certificate of Incorporation effective as of the date hereof. Notwithstanding anything to the contrary herein, the terms and conditions of this Article 4 shall not apply to any
Investor to the extent such Investor’s shares of Series C Preferred Stock were converted pursuant to Section 8 of Article IV of the Company’s Fifth Amended and Restated Certificate of Incorporation.” 
 3.4 Section 5.1(d) of the Rights Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 

“(d) Observation Rights. Harbert Venture Partners, L.L.C. (“Harbert”) and CNF Investments II,
LLC (“CNF”) shall have the right to receive notice of all meetings of the Board of Directors and to appoint one representative to attend any such meeting as a nonvoting observer, in addition to the Harbert Director (as defined
below) and in addition to any other member of the Company’s Board of Directors affiliated with Harbert or CNF. Tullis-Dickerson Capital Focus III, L.P. (“T-D”) shall have the right to receive notice of all meetings of the Board
of Directors and to appoint two representatives to attend any such meeting as nonvoting observers, in addition to any other member of the Company’s Board of Directors affiliated with T-D.” 
 3.5 Section 5.1(o) of the Rights Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 

“(o) Nature of Business. The Company shall continue to conduct its business without material change from the
nature of the business contemplated in the written

  

 8 

 
materials delivered to the Investors prior to the date hereof, except as approved by the Board of Directors of the Company, including approval by the Harbert Director and the Intersouth Director
(as defined in Section 6.1 below).” 
 3.6 A new Section 5.1(r) of the Rights Agreement shall be added as
follows: 
 “(r) Expenses of Directors. The Company shall promptly reimburse in full, each director
of the Company and one observer of each of T-D and CNF appointed pursuant to Section 5.1(d) hereof who is not an employee of the Company for all of his reasonable out-of-pocket expenses incurred in attending each meeting of the Board of
Directors of the Company or any committee thereof.” 
 3.7 Section 5.2(c) of the Rights Agreement shall be deleted in
its entirety and the following substituted in lieu thereof: 
 “(c) Sale of Assets. The Company shall
not effect any sale, lease, assignment, transfer, pledge, license, encumbrance or other conveyance of any material portion of the assets (including without limitation any technology or Intellectual Property) or operations or the revenue or income
generating capacity of the Company (other than inventory in the ordinary course of business and other assets reasonably and in good faith determined by the Company to be obsolete or no longer necessary to the business of the Company), or to take any
such action that has the effect of any of the foregoing, other than with the approval of (i) the Board of Directors and (ii) Intersouth Partners VI, L.P. and two or more of Harbert, T-D or CNF (the “Approval Threshold”)
(which approval shall be in writing).” 
 3.8 Upon consummation of the Series C-1 Closing, the term “Series C
Holder” and “Preferred Holders” under the Rights Agreement shall be deemed to include all holders of C-1 Preferred Stock and the terms “Series C Stock,” “Series C Preferred Stock” and
“Preferred Stock” shall be deemed to include the Series C-1 Preferred Stock for all purposes under the Rights Agreement. 
  

	 	4.	Company Consent to Joinder and Purchase. The Company hereby consents to the joining of the Additional Purchasers as parties to the Agreements, and the purchase
of the Shares by the Purchasers and the Additional Purchasers as contemplated herein. Such Shares shall be entitled to all of the rights and subject to all of the terms and conditions set forth in the Agreements, and the purchase of such Shares by
the Additional Purchasers shall be governed by all of the terms of the Agreements. 

  

	 	5.	Amendments to Schedules and Exhibits. EXHIBIT A to the Rights Agreement shall be amended to add the Additional Purchasers to such
EXHIBIT A. Exhibit A (“Schedule of Purchasers”) to the Purchase Agreement shall be amended and supplemented to include the Additional Purchasers and the Shares being purchased by the Additional Purchasers and the
Purchasers in this Additional Closing and the Series C-1 Preferred Stock being purchased in the Series C-1 Closing as set forth on Schedule 1 attached hereto. 

  

 9 

	 	6.	Second Closing. All references to the “Second Closing” shall be deleted from the Purchase Agreement. 

  

	 	7.	Governing Law. This Agreement shall be governed by and interpreted in accordance with the laws of the State of Delaware. 

  

	 	8.	Counterparts. This Agreement may be executed in one or more counterparts. 

  

	 	9.	Effect of Amendment. Except as amended hereby, the Agreements shall remain in full force and effect as originally executed or subsequently amended, as the case
may be. 

 [Remainder of Page Intentionally Left Blank] 
  

 10 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

					
	THE COMPANY:
	
	ALDAGEN, INC.
		
	By:	 	 /s/    W. Thomas Amick

	Name:	 	W. Thomas Amick
	Title:	 	Chairman, CEO
	
	CNF INVESTMENTS, LLC
		
	By:	 	 /s/    Robert J. Flanagan

	Name:	 	Robert J. Flanagan
	Title:	 	Manager
	
	TULLIS-DICKERSON CAPITAL FOCUS III, L.P.
		
	By:	 	Tullis-Dickerson Partners III, L.L.C.
		 	Its General Partner
			
		 	By:	 	 /s/    Lyle A. Hohnke

		 	Name:	 	Lyle A. Hohnke
		 	Title:	 	Partner
	
	HARBERT VENTURE PARTNERS MM, LX.C.
		
	By:	 	HMC- Virginia, Inc.
			
		 	By:	 	 /s/    William W. Brooke

		 	Name:	 	William W. Brooke
		 	Title:	 	Vice President
	
	INTERSOUTH PARTNERS VI, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VI, LLC
		 	Its General Partner
			
		 	By:	 	 /s/    Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, acting pursuant to Power of Attorney
	
	INTERSOUTH PARTNERS V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
			
		 	By:	 	 /s/    Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, acting pursuant to Power of Attorney

					
	
	INTERSOUTH AFFILIATES V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
			
		 	By:	 	 /S/    Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, acting pursuant to Power of Attorney

			
	
	AURORA ENRICHMENT FUND, LLC
	
	 By Aurora Enrichment Mangement, LLC
 Its Managing Member

		
	By:	 	 /s/    B. Jefferson Clark

	Name:	 	B. Jefferson Clark
	Title:	 	Manager
	
	HARBINGER/AURORA VENTURE FUND, LLC
	
	By HARBINGER/AURORA VENTURES, LLC
	Its Managing Member
		
	By:	 	 /s/    B. Jefferson Clark

		 	B. Jefferson Clark
		 	President
	
	HARBINGER/AURORA QP VENTURE FUND, LLC
	
	By HARBINGER/AURORA VENTURES, LLC
	Its Managing Member
		
	By:	 	 /s/    B. Jefferson Clark

		 	B. Jefferson Clark
		 	President
	
	THE AUGUST JACKSON COMPANY
		
	By:	 	 /s/    Frank Andrews

	Name:	 	Frank Andrews
	Title:	 	President & CEO

	
	
	 /s/    Nelson Chao

	Nelson Chao

			
	
	MAGELLAN’S COMPASS 1 LIMITED PARTNERSHIP
		
	By:	 	 /s/    W. Lowry Caudill

	Name:	 	W. Lowry Caudill
	Title:	 	President

			
	
	THE TRELYS FUND, L.P.
		
	By:	 	 /s/    Adrian N. Wilson

	Name:	 	Adrian N. Wilson
	Title:	 	Managing GP

			
	
	VILLAGE VENTURES PARTNERS FUND, L.P.
		
	By:	 	 Village Ventures Capital Partners I, LLC
 its general partner

	By:	 	Village Ventures, Inc., its managers
		
	By:	 	 /s/    Steven H.
Massicotte      

	Name:	 	Steven H. Massicotte
	Title:	 	Chief Operating Officer
	
	VILLAGE VENTURES PARTNERS FUND A, L.P.
		
	By:	 	 Village Ventures Capital Partners I, LLC
 its general partner

	By:	 	Village Ventures, Inc. its manager
		
	By:	 	 /s/    Steven H.
Massicotte      

	Name:	 	Steven H. Massicotte
	Title:	 	Chief Operating Officer

	
	
	 /s/    Andrew Balber      

	Andrew Balber

	
	
	 /s/    Jonathan M.
Lawrie      

	Jonathan M. Lawrie

			
	
	NEW MARKETS GROWTH FUND
		
	By:	 	 /s/    Mark Grovic      

	Name:	 	Mark Grovic
	Title:	 	Managing Director

 SECOND AMENDMENT TO AMENDED AND RESTATED INVESTOR RIGHTS 
 AGREEMENT 
 This Second Amendment to Amended and Restated Investor Rights Agreement (this “Amendment”) is entered into this 31st day of December, 2007 by and among Aldagen, Inc., a Delaware corporation (the “Company”),
and certain holders of the capital stock of the Company (the “Investors”). 
 WHEREAS, the Company and the
Investors have previously entered into an Amended and Restated Investor Rights Agreement, dated as of December 15, 2006, as amended by the First Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join
as a Party and First Amendment to Amended and Restated Investor Rights Agreement, dated as of September 12, 2007 (the “Rights Agreement”); and 
 WHEREAS, pursuant to Section 7.5 of the Rights Agreement, the Company and the Investors desire to amend the Rights Agreement in the manner and to the extent set forth herein. 
 NOW, THEREFORE, in consideration of the mutual agreements set forth herein, the Company and the Investors hereby agree as follows:

 1. Section 6.1 of the Rights Agreement shall be amended by deleting such Section 6.1 in its entirety and
substituting the following in lieu thereof: 
 6.1 Election of Directors. The Board of Directors of the
Company will consist of seven (7) persons. The Preferred Holders and Common Holders shall, whether by meeting, action by written consent of lieu of a meeting, or otherwise, act in all capacities and vote the shares of capital stock of the
Company now or hereafter owned or controlled by them so as to cause and maintain the election to the Board of Directors of the Company of (a) two representatives of the holders of a majority of Common Stock held by the Common Holders, one of
which shall be the chief executive officer of the Company (“CEO”), who shall initially be Tom Amick as the CEO, and the other shall be an individual not affiliated with the Company or any of the Investors, who
shall initially be Martin Murphy, (b) one designee of Harbert (the “Harbert Director”), who shall initially be William Brooke, (c) one designee of Intersouth Partners VI, L.P. (the “Intersouth
Director”), who shall initially be Garheng Kong, (d) one designee nominated by a majority of the Common Holders and the Junior Holders, voting together as a single class, who shall initially be B. Jefferson Clark, and (e) two
designees, not affiliated with the Company or any of the Investors, nominated by the Board of Directors of the Company. Harbert, Intersouth Partners VI, the Junior Holders, the Common Holders or the Board of Directors may elect at any time to
replace their designee on the Board of Directors, in which case all parties will vote to remove their then-current designee(s) and elect new designee(s) of that voting group. Upon request, the Harbert Director and Intersouth Director shall be
appointed to any committee of the Board of Directors. 

 2. The provisions of the Rights Agreement are hereby amended and modified by the provisions
of this Second Amendment. If any of the provisions of the Rights Agreement are materially different from or inconsistent with the provisions of this Second Amendment, the provisions of this Second Amendment shall control, and the provisions of the
Rights Agreement shall, to the extent of such difference or inconsistency, be deemed to be amended and modified. 
 3. This
Second Amendment and the Rights Agreement, as amended and modified by the provisions of this Second Amendment, shall constitute and shall be construed as a single agreement. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	COMPANY:
	
	ALDAGEN, INC.
		
	By:	 	 /s/ Edward L. Field

		 	Edward L. Field
		 	President
	
	CNF INVESTMENTS II, LLC
		
	By:	 	 /s/ Joseph Del Guercio

	Name:	 	Joseph Del Guercio
	Title:	 	Managing Director
	
	TULLIS-DICKERSON CAPITAL FOCUS III, L.P.
		
	By:	 	 Tullis-Dickerson Partners III, L.L.C.
 Its General Partner

		
	By:	 	 /s/ Lyle A. Hohnke

	Name:	 	Lyle A. Hohnke
	Title:	 	Partner

			
	
	INTERSOUTH PARTNERS VI, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VI, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name:	 	Garheng Kong
	Title:	 	Member, acting pursuant to Power of Attorney
	
	INTERSOUTH PARTNERS V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name:	 	Garheng Kong
	Title:	 	Member, acting pursuant to Power of Attorney
	
	INTERSOUTH AFFILIATES V, L.P.
		
	By:	 	INTERSOUTH AFFILIATES V, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name:	 	Garheng Kong
	Title:	 	Member, acting pursuant to Power of Attorney

			
	AURORA ENRICHMENT FUND, L.L.C.
	
	By: AURORA ENRICHMENT MANAGEMENT CO., L.L.C.
	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	B. Jefferson Clark
		 	Manager

  

			
	HARBINGER/AURORA VENTURE FUND, L.L.C.
	
	By: HARBINGER/AURORA VENTURES, L.L.C.
	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	B. Jefferson Clark
		 	President

  

			
	HARBINGER/AURORA QP VENTURE FUND, L.L.C.
	
	By: HARBINGER/AURORA VENTURES, L.L.C.
	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	B. Jefferson Clark
		 	President

  

			
	THE TRELYS FUNDS, L.P.
		
	By:	 	 /s/ Adrian N. Wilson

	Name:	 	Adrian N. Wilson
	Title:	 	Managing GP

  

			
	TALL OAKS STEMCO PARTNERS, LP
		
	By:	 	 /s/ Kathryne Carr

	Name:	 	Kathryne Carr
	Title:	 	Managing Director

  

	
	 /s/ Andrew Balber

	Andrew Balber

  

	
	 /s/ Nelson Chao

	Nelson Chao

  

	
	 /s/ Jonathon M. Lawrie

	Jonathon M. Lawrie

 SECOND AMENDMENT TO SERIES C PREFERRED STOCK PURCHASE AGREEMENT 
 AND AGREEMENT TO PURCHASE SHARES AND JOIN AS A PARTY AND THIRD 
 AMENDMENT TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
 This Second Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a Party and Third Amendment to Amended and Restated Investor Rights Agreement (this “Agreement”) dated as of
April 15, 2008 (the “Effective Date”) by and among Aldagen, Inc., a Delaware corporation (the “Company”), each of those persons and entities that previously purchased shares of the Series C Preferred Stock of
the Company and committed to purchase shares of the Series C-1 Preferred Stock of the Company (the “Series C-1 Preferred”) pursuant to the Purchase Agreement (defined below) and whose names are set forth on EXHIBIT
A hereto as “Purchasers” (each, a “Purchaser” and collectively, the “Purchasers”), and each of those entities that propose to purchase shares of the Series C-1 Preferred pursuant hereto and
whose names are set forth on EXHIBIT A hereto as “Additional Purchasers” (each, an “Additional Purchaser” and together, the “Additional Purchasers”). 
 WITNESSETH: 
 WHEREAS, the Company, the Purchasers and other investors have entered into a Series C Preferred Stock Purchase Agreement dated December 15, 2006 as amended by a First Amendment to Series C Preferred Stock Purchase Agreement and
Agreement to Purchase Shares and Join as a Party and First Amendment to Amended and Restated Investor Rights Agreement dated September 12, 2007 (the “Purchase Agreement”), and the Company and certain holders of capital stock of
the Company have entered into an Amended and Restated Investor Rights Agreement dated December 15, 2006 as amended by a First Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a Party and
First Amendment to Amended and Restated Investor Rights Agreement dated September 12, 2007, as further amended by the Second Amendment to Amended and Restated Investor Rights Agreement dated December 31, 2007 (the “Rights
Agreement”, and together with the Purchase Agreement, the “Agreements”); 
 WHEREAS, the Additional
Purchasers and the Purchasers propose to purchase shares of the Series C-1 Preferred pursuant to the terms and conditions of the Purchase Agreement, as amended hereby; 
 WHEREAS, Section 2.4 of the Purchase Agreement provides that the purchase of the Series C-1 Preferred shall be made by the Purchasers pursuant to a closing occurring within 30 days of notice to the
Purchasers by the Company of achievement of certain milestones, and Section 7.5 of the Rights Agreement and Section 3.8 of the First Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a
Party and First Amendment to Amended and Restated Investor Rights Agreement, dated September 12, 2007 provide that an additional purchaser of the Series C-1 Preferred shall become a party to the Rights Agreement; 
 WHEREAS, the Company desires to issue, and the Purchasers and the Additional Purchasers each desire to purchase, subject to the terms and
conditions of the Purchase Agreement (as amended hereby), approximately $18.4 million of Series C-1 Preferred as set forth under “Shares Purchased at Series C-1 Closing” on EXHIBIT A to the Purchase
Agreement (as amended hereby); 
  

 1 

 WHEREAS, the Additional Purchasers have agreed to be bound by the terms of the Agreements
and to become parties to the Agreements, as amended as set forth herein; 
 WHEREAS, the Company, the Purchasers and the
Additional Purchasers each desire to amend certain provisions of the Rights Agreement as set forth herein; and 
 NOW,
THEREFORE, in consideration of the premises, the covenants of the parties set forth below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 1. Capitalized Terms. Terms that are used herein with initial capital letters and that are not otherwise defined shall have the
meanings given to them in the Purchase Agreement. 
 2. Amendment of the Purchase Agreement. The first paragraph of
Section 2.4 of the Purchase Agreement shall be deleted in its entirety and the following substituted in lieu thereof: 
 “2.4 Series C-1 Closing. In the event the Company’s Board of Directors (the “Board”) in good faith determines that the Company has achieved the Milestones (as defined below), the Company shall deliver a
notice to each of the Purchasers and Additional Purchasers with shares listed opposite their names on EXHIBIT A under the heading “Shares Purchased at Series C-1 Closing” (collectively “C-1
Purchasers”) advising the C-1 Purchasers of the Board’s determination. Within 10 days after the Board delivers such notice to such C-1 Purchasers, Intersouth VI and at least two of either Harbert, Tullis-Dickerson Capital Focus III,
L.P. (“T-D”) or CNF Investments II, LLC (“CNF”) shall decide whether they concur with the Board’s determination that the Milestones have been achieved. In the event Intersouth VI and at least two of either
Harbert, T-D or CNF agree in writing (each in their sole discretion) that the Milestones have been achieved (“Milestone Approval”), the Company shall sell Series C-1 Preferred Stock to the C-1 Purchasers in the amounts set forth in
the Schedule of Purchasers attached hereto as EXHIBIT A under the heading “Shares Purchased at Series C-1 Closing” at a purchase price of $1.0411 per share and subject to adjustment as set forth in the Restated
Certificate (as defined below). The Series C-1 Preferred Stock shall have the rights and preferences set forth in the Fifth Amended and Restated Certificate of Incorporation of the Company attached hereto as EXHIBIT C
(“Restated Certificate”). Unless otherwise agreed to by the Company and the C-1 Purchasers, within 10 days of notice to the C-1 Purchasers by the Company of such Milestone Approval and satisfaction of the conditions set forth in
Section 5.3 below (such date, the “Series C-1 Closing Date”), all C-1 Purchasers shall participate in the Series C-1 Preferred Stock closing (“Series C-1 Closing”) to the full extent of their obligation
to purchase shares in the Series C-1 Closing in the amount set forth adjacent to their names under the heading “Shares Purchased at Series C-1 Closing” on EXHIBIT A (“Pro Rata Amount”). Any shares of
Series C-1 Preferred Stock sold pursuant to this Section 2.4 shall be deemed to be “Shares” for all purposes of this Agreement with respect to the Series C-1 Closing and any C-1 Purchasers shall be deemed
“Purchasers” for all purposes of this Agreement with respect to the Series C-1 Closing. For purposes of this Agreement, “Milestones: shall mean, collectively, (i) the initiation by the Company of a Pivotal Trial (as
defined below) in cord blood transplant; or (ii) the successful completion of a Phase I

  

 2 

 
clinical trial in cardiovascular or peripheral vascular disease. “Pivotal Trial” means a clinical trial that is of appropriate size and design to establish that a product is safe
and effective for its intended use, to define warnings, precautions and adverse reactions that are associated with the product, and to support marketing approval for such product by the United States Food and Drug Administration. Notwithstanding
anything to the contrary in this Agreement, at any time on or before December 31, 2008, each C-l Purchaser shall have the right, but not the obligation, to purchase their Pro Rata Amount even if the Milestones have not been achieved.”

 3. Sale of Series C-1 Shares. (a) The Additional Purchasers and the Purchasers each hereby agree that all
conditions of the Purchase Agreement which are required to be met prior to its purchase of the number of shares of the Series C-1 Preferred set forth opposite its name on EXHIBIT A attached hereto have been met and
further agrees that the Series C-1 Closing shall occur on the Effective Date. Each of the Additional Purchasers and the Purchasers (other than Harbert) shall transmit to the Company, in accordance with the relevant provisions of the Purchase
Agreement, the amount set forth opposite its name on such EXHIBIT A in payment for the shares of the Series C-1 Preferred being purchased by it on or before April 17, 2008. 
 (b) Harbert has agreed to purchase an aggregate of 5,974,013 shares of the Series C-1 Preferred at the Series C-1 Closing (the
“Harbert Shares”). Harbert shall transmit to the Company $1,200,007.26 in cash and shall cancel an obligation of the Company to it for $19,538.00 on or before April 17, 2008 in payment for 1,171,401 shares of the Series C-1
Preferred being purchased by it (the “Initial Harbert Shares”), and Harbert (or its Permitted Assignees as defined below) shall transmit to the Company $5,000,000.00 on or before April 24, 2008 as payment for the remaining
4,802,612 shares of the Series C-1 Preferred (the “Assignable Harbert Shares”). At its election, Harbert may assign the right, in whole or in part, to purchase the Assignable Harbert Shares to one or more affiliates of Harbert or
other persons or entities affiliated or associated therewith, including Harbert’s members, limited partners, general partners, affiliated companies, affiliated funds or the direct or indirect owners or affiliates of such members, limited
partners, general partners, affiliated companies or affiliated funds (the “Permitted Assignees”). Such assignment, if made, shall not relieve Harbert from its obligation to purchase any Assignable Harbert Shares for which any of the
Permitted Assignees have failed to make its required payment to the Company in respect of Assignable Harbert Shares for which the right to purchase has been assigned to it by April 24, 2008. The Company shall sell to any such Permitted Assignee
of Harbert who meets its funding obligation on or before April 24, 2008 the number of Assignable Harbert Shares for which the right to purchase has been assigned to it and such Permitted Assignee shall be deemed an “Additional
Purchaser” for the purposes of this Agreement. Through April 24, 2008, the Company agrees to (i) maintain an electronic data room containing materials relating to the Company and its business (the “Dataroom”) and
update the Dataroom with information available as of the date hereof, if responsive to reasonable requests from Harbert or Permitted Assignees, the reasonableness of such requests to be determined by the Company in its sole discretion; and
(ii) provide access to any Permitted Assignees who request access to the Dataroom. Except as set forth in the preceding sentence, the Company shall have no obligation to supplement or update the materials in the Dataroom. Access for a Permitted
Assignee to the Dataroom shall be conditioned upon such Permitted Assignee agreeing to maintain the confidentiality of the materials and information contained in the Dataroom. Notwithstanding the foregoing, the obligation of Harbert (or its
Permitted Assignees) to purchase the Assignable Harbert Shares on or before April 24, 2008, is absolute and unconditional. 
  

 3 

 (c) The Additional Purchasers agree to be bound by all the terms and conditions of the
Agreements applicable to “Purchasers” and “Investors” as defined therein. 
 4. Closing Conditions.
All conditions to the Purchasers’ and the Additional Purchasers’ obligations at the Series C-1 Closing, as specified in Section 5.3 of the Purchase Agreement, have been satisfied as of the Effective Date, and no updates or additional
conditions shall be required prior to the funding of the Series C-1 Closing as described in Section 3 above. 
 5.
Company Consent to Joinder and Purchase. The Company hereby consents to the joining of the Additional Purchasers as parties to the Agreements, and the purchase of the shares of Series C-1 Preferred by the Purchasers and the Additional
Purchasers as contemplated herein. Such shares shall be entitled to all of the rights and subject to all of the terms and conditions set forth in the Agreements, and the purchase of such shares by the Additional Purchasers shall be governed by all
of the terms of the Agreements. 
 6. Amendments to Schedules and Exhibits. EXHIBIT A to the
Rights Agreement shall be amended to add the Additional Purchasers to such EXHIBIT A. EXHIBIT A (“Schedule of Purchasers”) to the Purchase Agreement shall be amended and supplemented to include the
Additional Purchasers and the shares of Series C-1 Preferred being purchased by the Additional Purchasers and the Purchasers in the Series C-1 Closing as set forth on Schedule 1 attached hereto. 
 7. Governing Law. This Agreement shall be governed by and interpreted in accordance with the laws of the State of Delaware.

 8. Counterparts. This Agreement may be executed in one or more counterparts. 
 9. Effect of Amendment. Except as amended hereby, the Agreements shall remain in full force and effect as originally executed or
subsequently amended, as the case may be. 
 [Remainder of Page Intentionally Left Blank] 
  

 4 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

			
	THE COMPANY:
	
	ALDAGEN, INC.
		
	By:	 	 /s/ Edward L. Field

	Name:	 	Edward L. Field
	Title:	 	President & COO
	
	CNF INVESTMENTS II, LLC
		
	By:	 	 /s/ Joseph Del Guercio

	Name:	 	Joseph Del Guercio
	Title:	 	Managing Director
	
	TULLIS-DICKERSON CAPITAL FOCUS III, L.P.
		
	By:	 	Tullis-Dickerson Partners III, L.L.C.
		 	Its General Partner
		
	By:	 	 /s/ Lyle A. Hohnke

	Name:	 	Lyle A. Hohnke
	Title:	 	Principal
	
	HARBERT VENTURE PARTNERS, L.L.C.
		
	By:	 	Harbert Venture Partners MM, LLC,
		 	Its Managing Member
		
	By:	 	HMC-Virginia, Inc.,
		 	Its Manager
		
	By:	 	 /s/ William W. Brooke

	Name:	 	William W. Brooke
	Title:	 	Executive Vice President

					
	
	INTERSOUTH PARTNERS VI, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VI, LLC
		 	Its General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, Acting Pursuant to Power of Attorney

					
	
	INTERSOUTH PARTNERS V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, Acting Pursuant to Power of Attorney

					
	
	INTERSOUTH AFFILIATES V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Tide:	 	Member, Acting Pursuant to Power of Attorney
	
	INTERSOUTH PARTNERS VII, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VII, LLC
		 	Its General Partner
			
		 	By:	 	 /s/ Garheng Kong

		 	Name:	 	Garheng Kong
		 	Title:	 	Member, Acting Pursuant to Power of Attorney

			
	
	HARBINGER/AURORA VENTURE FUND, LLC
		
	By:	 	HARBINGER/AURORA VENTURES, LLC
	Its Managing Member
		
	By	 	 /s/    B. Jefferson
Clark      

		 	B. Jefferson Clark
		 	President
	
	HARBINGER/AURORA QP VENTURE FUND, LLC
		
	By	 	HARBINGER/AURORA VENTURES, LLC
	Its Managing Member
		
	By:	 	 /s/    B. Jefferson
Clark      

		 	B. Jefferson Clark
		 	President

			
	
	THE TRELYS FUNDS, L.P.
		
	By:	 	 /s/    Adrian N. Wilson      

	Name:	 	Adrian N. Wilson
	Title:	 	Managing General Partner

			
	
	TALL OAKS STEMCO PARTNERS, LP
		
	By:	 	 /s/    Kathryne F. Carr      

	Name:	 	Kathryne F. Carr
	Title:	 	Managing Director

	
	
	 /s/ Jonathan M. Lawrie

	Jonathan M. Lawrie

 FOURTH AMENDMENT TO AMENDED AND RESTATED INVESTOR 
 RIGHTS AGREEMENT 
 This Fourth Amendment to Amended and Restated Investor Rights Agreement (this “Amendment”) is entered into this 29th day of July, 2008 by and among Aldagen, Inc., a Delaware corporation (the “Company”), and certain
holders of the capital stock of the Company (the “Investors”). 
 WHEREAS, the Company and the Investors have
previously entered into an Amended and Restated Investor Rights Agreement, dated as of December 15, 2006, as amended by the First Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a Party and
First Amendment to Amended and Restated Investor Rights Agreement, dated as of September 12, 2007, as further amended by the Second Amendment to Amended and Restated Investor Rights Agreement, dated as of December 31, 2007, as further
amended by the Second Amendment to Series C Preferred Stock Purchase Agreement and Agreement to Purchase Shares and Join as a Party and Third Amendment to Amended and Restated Investor Rights Agreement, dated as of April 15, 2008 (collectively,
the “Rights Agreement”); and 
 WHEREAS, pursuant to Section 7.5 of the Rights Agreement, the amendment of
the Rights Agreement contemplated hereby requires the written consent of (i) the Junior Holders (as defined in the Rights Agreement), or their transferees, holding at least 66-2/3% of the shares of Junior Preferred and voting together as a
single group (treated as if converted at the conversion rate then in effect and including, for such purposes, shares of Common Stock into which any shares of Junior Preferred shall have been converted that are held by a Junior Holder) (the
“Junior Holders”), (ii) the Series C Holders and Series C-1 Holders (each as defined in the Rights Agreement), or their transferees, representing the Approval Threshold (as defined in the Rights Agreement) (the
“Requisite Investors”), and (iii) the Company; and 
 WHEREAS, the Company, the Junior Holders and the
Requisite Investors hereby agree that this Amendment shall amend the Rights Agreement as set forth herein. 
 NOW, THEREFORE, in
consideration of the mutual agreements set forth herein, the Company and the Investors hereby agree as follows: 
 1.
Section 3.1(b) of the Rights Agreement shall be amended by deleting such Section 3.1(b) in its entirety and substituting the following in lieu thereof: 
 “(b) The term “New Securities” shall mean any capital stock of the Company, whether now
authorized or not, and rights, options or warrants to purchase capital stock, and securities of any type whatsoever that are, or may become, convertible into capital stock; provided that the term “New Securities” does not include:
(i) the Investor Stock; (ii) securities issuable upon conversion of or with respect to Investor Stock; (iii) up to 10,000,000 shares of Common

 
Stock, and options, warrants or rights convertible into such Common Stock, issued to employees, consultants, officers or directors of the Company pursuant to any incentive agreement or
arrangement approved by the Board of Directors of the Company (the “Permitted Stock”); (iv) securities issued pursuant to any stock dividend, stock split, combination or other reclassification by the Company of any of
its capital stock; (v) securities issuable upon conversion or exercise of any convertible security, option, warrant or other right to acquire, if upon issuance of such convertible security, option, warrant or right the Company complied with the
provisions of this Section 3; (vi) warrants to purchase shares of Common Stock issued to banks or equipment lessors, as approved by the Board of Directors, such issuances not to exceed in the aggregate one percent (1%) of the
outstanding shares of Common Stock of the Company on a fully-diluted, as-converted into Common Stock basis; (vii) shares of capital stock or securities convertible into shares of capital stock issued in connection with business combinations or
corporate partnering agreements, as approved by the Board of Directors, such issuances not to exceed in the aggregate five percent (5%) of the outstanding shares of Common Stock of the Company on a fully-diluted, as-converted into Common Stock
basis; or (viii) shares of Common Stock sold in connection with a Qualified IPO.” 
 2. The provisions of the Rights
Agreement are hereby amended and modified by the provisions of this Amendment. If any of the provisions of the Rights Agreement are materially different from or inconsistent with the provisions of this Amendment, the provisions of this Amendment
shall control, and the provisions of the Rights Agreement shall, to the extent of such difference or inconsistency, be deemed to be amended and modified. 
 3. This Amendment and the Rights Agreement, as amended and modified by the provisions of this Amendment, shall constitute and shall be construed as a single agreement. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	COMPANY:
	
	ALDAGEN, INC.
		
	By:	 	 /s/ Edward L. Field

		 	Edward L. Field
		 	President

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	CNF INVESTMENTS II, LLC
		
	By:	 	 /s/ Joseph Del Guercio

			
	Name:	 	 Joseph Del Guercio

			
	Title:	 	 Managing Director

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page - 
  

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	TULLIS-DICKERSON CAPITAL FOCUS III, L.P.
		
	By:	 	Tullis-Dickerson Partners III, L.L.C.
		 	Its General Partner
		
	By:	 	 /s/ Lyle A. Hohnke

			
	Name:	 	 Lyle A. Hohnke

			
	Title:	 	  

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	HARBERT VENTURE PARTNERS, L.L.C.
		
	By:	 	 Harbert Venture Partners GP, LLC

			
	Its:	 	 Managing Member

			
		
	By:	 	 /s/ William W. Brooke

			
	Name:	 	 William W. Brooke

			
	Title:	 	 Executive Vice President

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	INTERSOUTH PARTNERS VI, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VI, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name: Garheng Kong
	Title: Member, acting pursuant to Power of Attorney
	
	INTERSOUTH PARTNERS V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name: Garheng Kong
	Title: Member, acting pursuant to Power of Attorney
	
	INTERSOUTH AFFILIATES V, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES V, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name: Garheng Kong
	Title: Member, acting pursuant to Power of Attorney
	
	INTERSOUTH PARTNERS VII, L.P.
		
	By:	 	INTERSOUTH ASSOCIATES VII, LLC
		 	Its General Partner
		
	By:	 	 /s/ Garheng Kong

	Name: Garheng Kong
	Title: Member, acting pursuant to Power of Attorney

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first
above written. 
  

			
	AURORA ENRICHMENT FUND, L.L.C.
		
	By:	 	AURORA ENRICHMENT MANAGEMENT CO., L.L.C.
		 	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	     B. Jefferson Clark
		 	     Manager
	
	HARBINGER/AURORA VENTURE FUND, L.L.C.
		
	By:	 	HARBINGER/AURORA VENTURES, L.L.C.
		 	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	     B. Jefferson Clark
		 	     President
	
	HARBINGER/AURORA QP VENTURE FUND, L.L.C.
		
	By	 	HARBINGER/AURORA VENTURES, L.L.C.
		 	Its Managing Member
		
	By:	 	 /s/ B. Jefferson Clark

		 	     B. Jefferson Clark
		 	     President

 Aldagen, Inc. 
 Fourth Amendment to Amended and Restated Investor Rights Agreement 
 - Signature Page -

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