Document:

EX-10.5

 Exhibit 10.5 
  

 
  

BRS-TUSTIN SAFEGUARD ASSOCIATES II, LLC 

Multi Tenant Industrial/Commercial Lease 

(Net) 

Between 

BRS-TUS7TN SAFEGUARD ASSOCIATES II, LLC, 

a Delaware limited liability company 

(LESSOR) 
 and

 PFEIVEX INC, 

a Delaware corporation 

(LESSEE) 

Date: June 22, 2010 
  

 
  

 TABLE OF CONTENTS 

 

							
	 	  	 	  	PAGE	 
		  	SUBJECT MATTER	  			
			
	Paragraph 1.	  	BASIC PROVISIONS (“BASIC PROVISIONS”)	  	 	1	  
			
	Paragraph 2.	  	PREMISES, PARKING AND COMMON AREAS	  	 	3	  
			
	Paragraph 3.	  	TERM	  	 	5	  
			
	Paragraph 4.	  	RENT	  	 	5	  
			
	Paragraph 5.	  	SECURITY DEPOSIT	  	 	8	  
			
	Paragraph 6.	  	USE	  	 	8	  
			
	Paragraph 7.	  	MAINTENANCE, REPAIRS, UTILITY INSTALLATIONS, TRADE FIXTURES AND ALTERATIONS	  	 	10	  
			
	Paragraph 8.	  	INSURANCE; INDEMNITY	  	 	13	  
			
	Paragraph 9.	  	DAMAGE OR DESTRUCTION	  	 	16	  
			
	Paragraph 10.	  	REAL PROPERTY TAXES	  	 	18	  
			
	Paragraph 11.	  	UTILITIES; RENTAL ABATEMENT EVENTS	  	 	18	  
			
	Paragraph 12.	  	ASSIGNMENT AND SUBLETTING	  	 	19	  
			
	Paragraph 13.	  	DEFAULT; BREACH; REMEDIES	  	 	21	  
			
	Paragraph 14.	  	CONDEMNATION	  	 	23	  
			
	Paragraph 15.	  	BROKERS	  	 	24	  
			
	Paragraph 16.	  	ESTOPPEL CERTIFICATE AND FINANCIAL STATEMENTS	  	 	24	  
			
	Paragraph 17.	  	LESSOR’S LIABILITY	  	 	24	  
			
	Paragraph 18.	  	SEVERABILITY	  	 	24	  
			
	Paragraph 19.	  	INTEREST ON PAST-DUE OBLIGATIONS	  	 	24	  
			
	Paragraph 20.	  	TIME OF ESSENCE	  	 	24	  
			
	Paragraph 21.	  	RENT DEFINED	  	 	24	  
			
	Paragraph 22.	  	NO PRIOR OR OTHER AGREEMENTS	  	 	24	  
			
	Paragraph 23.	  	NOTICES	  	 	24	  
			
	Paragraph 24.	  	WAIVERS	  	 	25	  
			
	Paragraph 25.	  	INTENTIONALLY OMITTED	  	 	25	  
			
	Paragraph 26.	  	NO RIGHT TO HOLDOVER	  	 	25	  
			
	Paragraph 27.	  	CUMULATIVE REMEDIES	  	 	25	  
			
	Paragraph 28.	  	COVENANTS AND CONDITIONS	  	 	25	  
			
	Paragraph 29.	  	BINDING EFFECT; CHOICE OF LAW	  	 	25	  
			
	Paragraph 30.	  	SUBORDINATION; ATTORNMENT; NON-DISTURBANCE	  	 	25	  
			
	Paragraph 31.	  	ATTORNEYS’ FEES	  	 	26	  
			
	Paragraph 32.	  	LESSOR’S ACCESS; SHOWING PREMISES; REPAIRS	  	 	26	  
			
	Paragraph 33.	  	AUCTIONS	  	 	26	  
			
	Paragraph 34.	  	SIGNS	  	 	26	  
			
	Paragraph 35.	  	TERMINATION; MERGER	  	 	26	  
			
	Paragraph 36.	  	CONSENTS	  	 	26	  

  
 (i) 

							
			
	Paragraph 37.	  	INTENTIONALLY DELETED	  	 	27	  
			
	Paragraph 38.	  	QUIET POSSESSION	  	 	27	  
			
	Paragraph 39.	  	RULES AND REGULATIONS	  	 	27	  
			
	Paragraph 40.	  	SECURITY MEASURES	  	 	27	  
			
	Paragraph 41.	  	RESERVATIONS	  	 	27	  
			
	Paragraph 42.	  	PERFORMANCE UNDER PROTEST	  	 	27	  
			
	Paragraph 43.	  	AUTHORITY	  	 	27	  
			
	Paragraph 44.	  	CONFLICT	  	 	27	  
			
	Paragraph 45.	  	OFFER	  	 	27	  
			
	Paragraph 46.	  	AMEDMENTS	  	 	27	  
			
	Paragraph 47.	  	MULTIPLE PARTIES	  	 	27	  
			
	Paragraph 48.	  	CONSTRUCTION	  	 	27	  

 Exhibit A PREMISES 

Exhibit B INDUSTRIAL CENTER 
 Exhibit C LEASEHOLD
IMPROVEMENT AGREEMENT 
 Exhibit D FORM OF ESTOPPEL CERTIFICATE 

Exhibit E RULES AND REGULATIONS 
 Exhibit F FORM OF
SUBORDINATION AGREEMENT 
 Exhibit G HAZARDOUS SUBSTANCES SURVEY FORM 

Exhibit H NOTICE OF LEASE TERM DATES 

  
 (ii) 

 BRS-TUSTIN SAFEGUARD ASSOCIATES II, LLC 

Multi-Tenant Industrial/Commercial Lease 

(Net) 
 ROSELLE
TECHNOLOGY PARK 
  

	 	1.	Basic Provisions (“Basic Provisions”). 

 1.1 Parties:
This Lease (“Lease”), effective June 22, 2010 (“Effective Date”), is made by and between BRS-TUSTIN SAFEGUARD ASSOCIATES II, LLC, a Delaware limited liability company (“Lessor”) and
PFENEX INC., a Delaware corporation (“Lessee”), (collectively the “Parties,” or individually a “Party”). 

1.2 Premises; Parking; Exterior Equipment Area; Roof/Air Compressor. 

(a) Premises: The entire Building (“Building”), including all improvements therein or to be provided by Lessor
under the terms of this Lease, located at 10790 Roselle Street, San Diego, California 92121, and containing approximately twenty two thousand eight hundred thirty three (22,833) rentable square feet as outlined on Exhibit A attached
hereto (“Premises”). In addition to Lessee’s rights to use and occupy the Premises as hereinafter specified, Lessee shall have non-exclusive rights to the Common Areas (as defined in Paragraph 2.7 below) as hereinafter
specified, but shall not have any rights to the roof or exterior walls of the Building or to any other buildings in the Industrial Center. The Premises, the Building, the Common Areas, the land upon which they are located, along with all other
buildings and improvements thereon, are herein collectively referred to as the “Industrial Center” and are depicted on Exhibit B. (Also see Paragraph 2.) 

(b) Parking: Lessee shall be entitled to the use, on an unreserved as-available basis, of sixty eight (68) vehicle parking
spaces within the Industrial Center and four (4) reserved vehicle parking spaces within the Industrial Center (collectively, the “Parking Spaces”). (Also see Paragraph 2.6.) 

(c) Exterior Equipment Area: Lessee shall have an exclusive license to use a portion of the exterior yard and equipment area
located within the Industrial Center and identified on Exhibit A (the “Exterior Equipment Area”) in connection with its operations at the Premises, provided that Lessee complies with any reasonable rules and regulations
concerning the use of such Exterior Equipment Area imposed by Lessor at any time during the Term of this Lease. Said license shall be coterminous with this Lease and any portion of the Exterior Equipment Area used by Lessee shall be maintained by
Lessee in the same manner required for the Premises under this Lease. As part of the Leasehold Improvements (as defined in the Leasehold Improvement Agreement attached to this Lease as Exhibit C), Lessee shall have the right to expand
the existing Exterior Equipment Area as shown on Exhibit A and may grade and improve the Exterior Equipment Area, including installing fencing surrounding the Exterior Equipment Area, subject to Lessor’s prior approval and
Lessee’s compliance with all of the requirements for the Leasehold Improvements set forth in this Lease and the Leasehold Improvement Agreement attached to this Lease as Exhibit C. If Lessee installs such fencing, Lessee agrees to
provide keys to the gates of the Exterior Equipment Area to Lessor. In no event shall Lessee’s use of the Exterior Equipment Area adversely impact the use of the existing parking spaces or access ways at the Industrial Center. 

(d) Roof/Air Compressor: During the Term, Lessee shall be permitted to install, maintain and operate an air compressor on the
roof of the Building (the “Compressor”), the size, weight and precise location of which shall be subject to Lessor’s prior written approval not to be unreasonably withheld, conditioned or delayed, and pursuant to plans, all of
which have been approved in writing by Lessor (which approval shall not be unreasonably withheld, conditioned or delayed), at Lessee’s sole cost and expense. Lessee shall obtain Lessor’s prior written consent, which consent shall not be
unreasonably withheld, conditioned or delayed, to any roof penetrations and any such penetrations permitted by Lessor shall be performed at Lessee’s expense by Lessor’s contractors if required by Lessor in accordance with any roof
warranty. The installation, maintenance and operation of the Compressor shall be in accordance with the provisions of this Lease and shall be performed at Lessee’s sole cost and expense. Lessee will ensure that the Compressor will be installed
by licensed contractors in accordance with all federal, state and local rules and building codes. Lessee will obtain, at its sole cost and expense, all permits, licenses or approvals required to install and operate the Compressor and shall repair
any and all damage to the Industrial Center (including, but not limited to, the roof of the Building) caused as a result of Lessee’s installation of the Compressor. In the event Lessor repairs or replaces the roof during the Lease Term, Lessee
will relocate or, if necessary, remove the Compressor from the roof at Lessee’s sole cost upon receipt of written request from Lessor. Lessor shall use commercially reasonable efforts to avoid the removal of the Compressor during any such
repair or replacement of the roof. Lessee shall be able to place the Compressor on the roof, at Lessee’s sole cost and expense, after Lessor completes repairing or replacing the roof. Lessor may have its representative present at the
installation or any reinstallation of the Compressor and the Compressor shall be properly screened and shall not be visible by someone standing in the vicinity of the Industrial Center. The Compressor shall be included within the coverage of
all insurance policies required to be maintained by Lessee under the Lease. 

  
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 1.3 Term: The term of this Lease shall be for a period of ten (10) years
(“Original Term”) commencing on the date (the “Commencement Date”) which is the later of (a) April 1, 2011, and (b) the date that Lessor delivers possession of the Premises to Lessee after completion
of Lessor’s Work (as defined in the Leasehold Improvement Agreement attached to this Lease as Exhibit C) and expiring on the date one day prior to the tenth
(10th) anniversary of the Commencement Date or if the Commencement Date does not occur on the first day of the month, the last day of the month in which the tenth (10th) anniversary of
the Commencement Date occurs (the “Expiration Date”). The Commencement Date and Expiration Date shall be documented in the form of Exhibit H attached hereto. For purposes of this Lease, the “Term” of
this Lease shall refer to the Original Term, as it may be extended or renewed by any properly exercised options granted hereunder. (Also see Paragraph 3.) 

1.4 Early Possession: Lessee shall have the right to occupy the Premises for the sole purpose of installing the Leasehold
Improvements in the Premises in accordance with the Leasehold Improvement Agreement attached as Exhibit C to this Lease and installing all furniture. fixtures and equipment and otherwise preparing the Premises for occupancy from and after the
date of the mutual execution and delivery of this Lease by the Parties and Lessee’s delivery to Lessor of advance rent required under Paragraph 1.6 below, the Security Deposit required under Paragraph 1.8 below, and the insurance certificates
required under Paragraph 8 below (the “Early Possession Date”). In addition, from and after February 1, 2011, Lessee shall have the right to commence the conduct of its business in the Premises. None of the early access or
occupancy rights set forth in this Section 1.4 shall advance the Commencement Date of this Lease. (Also see Paragraphs 3.2 and 3.3.) 

1.5 Base Rent: Payable monthly, on the first day of each month, in the amount described below, calculated on a net basis
(“Base Rent”), and commencing on the Commencement Date. (Also see Paragraph 4.) 
  

									
	 Month of Original Term
	  	Monthly
Installment of
Base Rent	 	  	Approx.
Monthly
Rate PSF	 
	 1 – 12*
	  	$	27,399.60	  	  	$	1.20	  
	 13 – 24
	  	$	28,221.59	  	  	$	1.24	  
	 25 – 36
	  	$	29,068.24	  	  	$	1.27	  
	 37 – 48
	  	$	29,940.28	  	  	$	1.31	  
	 49 – 60
	  	$	30,838.49	  	  	$	1.35	  
	 61 – 72
	  	$	31,763.65	  	  	$	1.39	  
	 73 – 84
	  	$	32,716.56	  	  	$	1.43	  
	 85 – 96
	  	$	33,698.05	  	  	$	1.48	  
	 97 – 108
	  	$	34,708.99	  	  	$	1.52	  
	 109 – 120
	  	$	35,750.26	  	  	$	1.57	  

  

	*	Subject to abatement of fifty percent (50%) of monthly Base Rent for the first (1st) year of the Original Term in accordance with the provisions of Paragraph 4.1 of
this Lease. 

 1.6 Advance Rent Paid Upon Execution: Twenty Thousand Three Hundred Twenty One and 37/100 Dollars
($20,321.37) representing Lessee’s first installment of Base Rent and Lessee’s Share of Common Area Operating Expenses due for the Original Term. 

1.7 Lessee’s Share of Common Area Operating Expenses: Thirty one and 76/100 percent (31.76%) as to the Industrial
Center and one hundred and No/100 percent (100%) as to the Building (“Lessee’s Share”) which may be adjusted by Lessor from time to time, in Lessor’s reasonable discretion based on changes in the size of and/or number
of buildings comprising the Industrial Center. (Also see Subparagraph 4.2 (a)) 
 1.8 Security Deposit: Thirty Five
Thousand Seven Hundred Fifty and 26/100 Dollars ($35,750.26) (“Security Deposit”). (Also see Paragraph 5.) 

1.9 Permitted Use: Lessee shall use and occupy the Premises solely for general office, research and development, laboratory,
biotech manufacturing, warehouse and distribution uses and other related incidental uses, as may be permitted under existing zoning laws governing the Premises and for no other use or purpose without Lessor’s prior written consent
(“Permitted Use”). (Also see Paragraph 6.) 

  
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 1.10 (a) Real Estate Brokers. The following real estate broker(s) (collectively,
the “Brokers”) and brokerage relationships exist in this transaction and are consented to by the Parties (check applicable boxes): 

x     CB Richard Ellis represents Lessor exclusively
(“Lessor’s Broker”); and 
 x     Irving Hughes
represents Lessee exclusively (“Lessee’s Broker”). 
 (b) Payment to Brokers. Upon the execution of
this Lease by both Parties, Lessor shall pay to said Broker(s) jointly, or in such separate shares as they may mutually designate in writing, a fee as set forth in a separate written agreement between Lessor and said Broker(s) 

1.11 Guarantor(s): None. 

1.12 Addenda and Exhibits. Attached are Exhibits A through G, all of which constitute a part of this Lease. 

2. Premises, Parking and Common Areas. 

2.1 Letting. Lessor hereby leases to Lessee, and Lessee hereby leases from Lessor, the Premises, for the Term, at the rental,
and upon all of the terms, covenants and conditions set forth in this Lease. Unless otherwise provided herein, any statement of square footage set forth in this Lease, or that may have been used in calculating Base Rent, Lessee’s Share and/or
Common Area Operating Expenses, is an approximation which Lessor and Lessee agree is reasonable and Lessee’s Share based thereon is not subject to revision whether or not the actual square footage is more or less. 

2.2 Condition. Except as otherwise provided in this Paragraph 2.2 and Exhibit C to this Lease, Lessee agrees
(i) to accept the Premises on the Commencement Date as then being suitable for Lessee’s intended use and in its then existing “AS IS” condition, and (ii) that neither Lessor nor any of Lessor’s agents, representatives
or employees has made any representations as to the suitability, fitness or condition of the Premises for the conduct of Lessee’s business or for any other purpose. The Leasehold Improvements (defined in Exhibit C) shall be
installed in accordance with the terms and provisions of Exhibit C. Notwithstanding the foregoing, the Premises shall be delivered to Lessee on the Early Possession Date in broom clean condition with the roof, the compressor and all
heating, ventilation and air-conditioning, electrical, lighting, fire sprinkler, laboratory, plumbing and other Building systems servicing the Premises in good working order as of the Early Possession Date and the slab, foundation and all windows
properly sealed and watertight. If any of the foregoing are not in the required condition, Lessor shall, except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee setting forth with specificity the nature and
extent of such non-compliance, rectify same at Lessor’s expense; provided, that Lessee delivers Lessor written notice of a non-compliance with this condition within six (6) months after the Commencement Date. 

2.3 Compliance with Covenants, Restrictions and Building Code. Lessor warrants that to the actual knowledge of Lessor any
improvements (other than those constructed by Lessee or at Lessee’s direction) on or in the Premises shall comply with all Applicable Laws (as defined below) in effect and enforced on the Effective Date. Lessor further warrants to Lessee that
Lessor has no actual knowledge, without a duty of inquiry or investigation, of any claim having been made by any governmental agency that a violation or violations of Applicable Laws exists with regard to the Premises as of the Effective Date. For
purposes of the foregoing representation, Lessor’s actual knowledge shall be limited to the actual knowledge, without a duty of inquiry or investigation, of the person executing this Lease on behalf of Lessor, Hack Adams and the Building
Manager. Finally, Lessor warrants to Lessee that the exterior of the Building, the Common Areas, including the parking area for the Building, all Building systems and all restrooms in the Building shall comply with all Applicable Laws in effect and
enforced on the Effective Date. Without limiting the provisions of Exhibit C, said warranties shall not apply to any Leasehold Improvements, Alterations or Utility Installations (defined in Subparagraph 7.3 (a)) made or to be made by Lessee. If
the Premises do not comply with said warranties, Lessor shall, except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee given within six (6) months following the Commencement Date and setting forth with
specificity the nature and extent of such non-compliance, take such action, at Lessor’s expense, as may be reasonable or appropriate to rectify the non-compliance. Lessor makes no warranty that the Permitted Use in Paragraph 1.9 is permitted
for the Premises under Applicable Laws (as defined in Paragraph 2.4). Except as provided in Paragraph 4.2 below, Lessor shall be responsible at its sole cost and expense for all work and improvements to the Common Areas required under the ADA (as
defined below). 
 Lessee warrants that any improvements (other than those constructed by Lessor or at Lessor’s direction) on or
in the Premises, which are constructed or installed by Lessee, shall comply with all applicable covenants or restrictions of record and applicable building codes, regulations and ordinances in effect on the Commencement Date and throughout the Term
of this Lease. 

  
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Said warranty shall specifically apply to any Leasehold Improvements, Alterations or Utility Installations made or to be made by Lessee. Subject to the provisions of Exhibit C, if such
improvements constructed or installed by Lessee do not comply with said warranties, Lessee shall, except as otherwise provided in this Lease, promptly after receipt of written notice from Lessor or any governmental authority, take such action, at
Lessee’s expense, as may be deemed reasonable or appropriate by Lessor to rectify the non-compliance. 
 2.4 Acceptance of
Premises. Lessee hereby acknowledges: (a) that it has been advised to satisfy itself with respect to the condition of the Premises (including but not limited to the electrical and fire sprinkler systems, security, environmental aspects,
seismic and earthquake requirements, and compliance with the Americans With Disabilities Act (the “ADA”) and applicable zoning, municipal, county, state and federal laws, ordinances and regulations and any covenants or restrictions
of record (collectively, “Applicable Laws”) and the present and future suitability of the Premises for Lessee’s intended use; (b) that Lessee has made such investigation as it deems necessary with reference to such
matters, is satisfied with reference thereto; and (c) that neither Lessor, nor any of Lessor’s agents, has made any oral or written representations or warranties with respect to said matters other than as set forth in this Lease.

 2.5 Intentionally Deleted. 

2.6 Vehicle Parking. Lessee shall be entitled to use Parking Spaces in accordance with Subparagraph 1.2 (b) of the Basic
Provisions on those portions of the Common Areas designated from time to time by Lessor for parking, including, without limitation, in the parking areas immediately adjacent to the Building. Lessee shall not use more parking spaces than said number.
Said Parking Spaces shall be used for parking by vehicles no larger than full-size passenger automobiles, pick-up trucks or SUVs, herein called “Permitted Size Vehicles.” Vehicles other than Permitted Size Vehicles shall be parked and
loaded or unloaded as directed by Lessor in the Rules and Regulations (as defined in Paragraph 39) issued by Lessor. Lessee’s violation of this subparagraph shall constitute a material breach of this Lease (subject to applicable notice and cure
periods). (Also see Paragraph 2.9.) 
 (a) Lessee shall not permit or allow any vehicles that belong to or are controlled by Lessee
or Lessee’s employees, suppliers, shippers, customers, contractors or invitees to be loaded, unloaded, or parked in areas other than those designated by Lessor for such activities. 

(b) If Lessee permits or allows any of the prohibited activities described in this Paragraph 2.6, then Lessor shall have the right, without
notice, in addition to such other rights and remedies that it may have, to remove or tow away the vehicle involved and charge the cost to Lessee, which cost shall be immediately payable upon demand by Lessor. 

2.7 Common Areas - Definition. The term “Common Areas” is defined as all areas and facilities outside the
Premises and within the exterior boundary line of the Industrial Center and interior utility raceways within the Premises that are provided and designated by the Lessor from time to time for the general non-exclusive use of Lessor, Lessee and other
lessees of the Industrial Center and their respective employees, suppliers, shippers, customers, contractors and invitees, including parking areas, loading and unloading areas, trash areas, roadways, sidewalks, walkways, parkways, driveways and
landscaped areas (but excluding the Exterior Equipment Area, which shall be exclusive to Lessee). 
 2.8 Common Areas -
Lessee’s Rights. Lessor hereby grants to Lessee, for the benefit of Lessee and its employees, suppliers, shippers, contractors, customers and invitees, during the Original Term of this Lease, the non-exclusive right to use, in common with
others entitled to such use, the Common Areas as they exist from time to time, subject to any rights, powers, and privileges reserved by Lessor under the terms hereof or under the terms of any rules and regulations or restrictions governing the use
of the Industrial Center. Under no circumstances shall the right herein granted to use the Common Areas be deemed to include the right to store any property, temporarily or permanently, in the Common Areas. Any such storage shall be permitted only
by the prior written consent of Lessor or Lessor’s designated agent, which consent may be revoked at any time. In the event that any unauthorized storage shall occur then Lessor shall have the right, without notice, in addition to such other
rights and remedies that it may have, to remove the property and charge the cost to Lessee, which cost shall be immediately payable upon demand by Lessor. 

2.9 Common Areas - Rules and Regulations. Lessor or such other person(s) as Lessor may appoint shall have the exclusive control
and management of the Common Areas and shall have the right, from time to time, to establish, modify, amend and enforce reasonable Rules and Regulations with respect thereto in accordance with Paragraph 39. Lessee agrees to abide by and conform to
all such Rules and Regulations, and to cause its employees, suppliers, shippers, customers, contractors and invitees to so abide and conform. Lessor shall not be responsible to Lessee for the non-compliance with said rules and regulations by other
lessees of the Industrial Center, provided that Lessor shall enforce such Rules and Regulations in a uniform and nondiscriminatory manner. In no event shall the Rules and Regulations unreasonably interfere with Lessee’s use of the Premises as
permitted under this Lease or Lessee’s parking rights granted under this Lease or materially increase the obligations or decrease the rights of Lessee under this Lease. 

  
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 2.10 Common Areas - Changes. Lessor shall have the right, in Lessor’s sole
discretion, from time to time: 
 (a) To make changes to the Common Areas, including, without limitation, changes in the location,
size, shape and number of driveways, entrances, parking spaces, parking areas, loading and unloading areas, ingress, egress, direction of traffic, landscaped areas, walkways and utility raceways; 

(b) To close temporarily any of the Common Areas for maintenance purposes so long as reasonable access to the Premises remains available;

 (c) Intentionally omitted; 

(d) To add additional buildings and improvements to the Common Areas; 

(e) To use the Common Areas while engaged in making additional improvements, repairs or alterations to the Industrial Center, or any portion
thereof; and 
 (f) To do and perform such other acts and make such other changes in, to or with respect to the Common Areas and Industrial
Center as Lessor may, in the exercise of sound business judgment, deem to be appropriate. 
 Notwithstanding the foregoing, in connection
with any of the actions described in this Paragraph 2.10, Lessor shall not unreasonably interfere with Lessee’s operations at the Premises, including parking for, access to or visibility of the Premises; provided that any changes to the Common
Areas shall not materially and adversely affect Lessee’s use or enjoyment of or access to the Premises or parking areas or other rights under this Lease as contemplated by this Lease. 

3. Term. 
 3.1
Term. The Commencement Date, Expiration Date and Original Term of this Lease are as specified in Paragraph 1.3. 
 3.2
Early Possession. If an Early Possession Date is specified in Paragraph 1.4, Lessee shall be entitled to early occupancy of the Premises solely for the purpose of installing the Leasehold Improvements and Lessee’s furniture, fixtures,
equipment and other specialized leasehold improvements approved by Lessor and otherwise preparing the Premises for Lessee’s occupancy. Lessor and Lessee shall coordinate their respective work to be performed at the Premises during Lessee’s
early occupancy. All other terms of this Lease, however (including, but not limited to, the obligation to carry the insurance required by Paragraph 8 but excluding the obligation to pay Base Rent or Lessee’s Share of Common Area Operating
Expenses or, unless and until Lessee commences business operations from the Premises, to pay for utilities pursuant to Paragraph 11 hereof), shall be in effect during such period. Lessee agrees that Lessor’s completion of any improvements in
the Premises during the period of Lessee’s early occupancy of the Premises shall in no way constitute a constructive eviction of Lessee nor entitle Lessee to any abatement of Rent: provided, however that both Lessor and Lessee shall mutually
cooperate to conduct their improvements in a manner that will avoid unreasonable interference with the other party’s work. Any such early possession shall not affect nor advance the Expiration Date of the Term. 

3.3 Delay in Possession. If for any reason Lessor cannot deliver possession of the Premises to Lessee by the Early Possession
Date, if one is specified in Paragraph 1.4, or if no Early Possession Date is specified, by the Commencement Date, Lessor shall not be subject to any liability therefor, nor shall such failure affect the validity of this Lease, or the obligations of
Lessee hereunder, or extend the Term hereof, but in such case, Lessee shall not, except as otherwise provided herein, be obligated to pay rent or perform any other obligation of Lessee under the terms of this Lease until Lessor delivers possession
of the Premises to Lessee. 
 4. Rent. 

4.1 Base Rent. Lessee shall pay Base Rent and other rent or charges, as the same may be adjusted from time to time, to Lessor in
lawful money of the United States, without notice, offset or deduction, on or before the day on which it is due under the terms of this Lease. For purposes of this Lease, Base Rent and all other sums or charges due Lessor from Lessee hereunder may
be collectively referred to from time to time as “Rent’ Rent for any period during the Term hereof which is for less than one (1) full month shall be prorated on the basis of a thirty (30) day month. If the Commencement Date does
not occur on the first day of a calendar month, monthly Base Rent shall adjust on the applicable anniversary of the Commencement Date and Lessee shall pay monthly Base Rent for the portion of the calendar month ending on the Expiration Date at the
monthly Base Rent then in effect. Payment of Rent shall be made to Lessor at its address stated herein or to such other persons or at such other addresses as Lessor may from time to time designate in writing to Lessee. Notwithstanding anything to
the contrary contained in this Lease, Lessor and Lessee hereby agree that fifty percent (50%) of monthly Base Rent shall be abated for the first (1g) year of the Original Term; provided, that (i) Lessee agrees that notwithstanding the
foregoing monthly Base Rent abatement, Lessee shall observe and perform all of the other  

  
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terms, covenants and provisions set forth in this Lease, including without limitation, payment of all other Rent required to be paid by Lessee under this Lease, and (ii) in the event of a
Breach by Lessee under the terms of this Lease that results in termination of this Lease in accordance with the provisions of Paragraph 13 hereof, then as a part of the recovery set forth in Paragraph 13 of this Lease, Lessor shall be entitled to
the recovery of the then unamortized remaining balance of the Base Rent that was abated under the provisions of this Paragraph 4.1 (such amortization being calculated on a straight line basis over the entire Lease Term and such balance being
determined as of the date of such Breach). 
 4.2 Common Area Operating Expenses. Lessee shall pay to Lessor during the Term
hereof, in addition to the Base Rent, Lessee’s Share of all Common Area Operating Expenses, as hereinafter defined, during each calendar year of the Term of this Lease, in accordance with the following provisions: 

(a) “Common Area Operating Expenses” are defined, for purposes of this Lease, as all costs incurred by Lessor
relating to the ownership and operation of the Industrial Center, including, but not limited to, the following: 
 (i) The costs of
management, administration operation, repair, replacement and maintenance, in neat, clean, good order and condition, of the following: 

(aa) The Common Areas, including parking areas, loading and unloading areas, trash areas, roadways, sidewalks, walkways, parkways, driveways,
landscaped areas, striping, bumpers, irrigation systems, Common Area lighting facilities, fences and gates and the roof membrane and the non-structural portions of the roof (with respect to the roof, Lessee shall only be responsible for the costs
relating to the roof of the Building). 
 (bb) Intentionally omitted. 

(cc) Exterior signs and any tenant directories. 

(dd) Fire detection and sprinkler systems for the Building only. 

(ii) The cost of water, sewer, gas, electricity, telephone (as required for the fire monitoring system only) and any other utility systems to
service the Common Areas. 
 (iii) Trash disposal, property management and security services. 

(iv) Intentionally deleted. 

(v) Real Property Taxes (as defined in Paragraph 10.2) to be paid by Lessor for the Building and the Common Areas under Paragraph 10 hereof.

 (vi) The costs of the premiums for the insurance policies maintained by Lessor under Paragraph 8 hereof. 

(vii) Any reasonable deductible portion of an insured loss concerning the Building or the Common Areas (except to the extent such loss is
caused solely by Lessor’s negligence), not to exceed $50,000 per insured loss. 
 (viii) Any other services to be provided by Lessor
that are stated elsewhere in this Lease to be a Common Area Operating Expense. 
 (ix) Except as otherwise provided in this Lease,
replacing and/or adding improvements mandated by any governmental agency and any repairs or removals necessitated thereby, amortized over its useful life according to sound accounting principles consistent with those generally used by sophisticated
commercial landlords in the San Diego area (including interest on the un-amortized balance at the rate of 8% per annum), including any barrier removal work or other required improvements, alterations or work to any portion of the Common Areas
required under provisions of the ADA enacted or newly enforced after the date of this Lease. If any improvements, alterations or work is required to the Premises under the provisions of the ADA or any improvements, alterations or work is required to
the Common Areas under the ADA as a result of Lessee’s specific use or alteration or improvements to the Premises, excluding the initial Leasehold Improvements (collectively, “Lessee ADA Work”), then the cost of the Lessee ADA Work
shall be borne solely by Lessee and shall not be included as part of the Common Area Operating Expenses. 

  
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 (x) The cost of any capital improvements made to the Industrial Center after the Commencement
Date amortized over its useful life according to sound accounting principles consistent with those generally used by sophisticated commercial landlords in the San Diego area (including interest on the un-amortized balance at the rate of 8% per
annum). 
 (b) Any Common Area Operating Expenses and Real Property Taxes that are specifically attributable to the Building or to any
other building in the Industrial Center or to the operation, repair and maintenance thereof, shall be allocated entirely to the Building or to such other building. However, any Common Area Operating Expenses and Real Property Taxes that are not
specifically attributable to the Building or to any other building or to the operation, repair and maintenance thereof, shall be equitably allocated by Lessor to all buildings in the Industrial Center. 

(c) The inclusion of the improvements, facilities and services set forth in Subparagraph 4.2 (a) shall not be deemed to impose an
obligation upon Lessor to either have said improvements or facilities or to provide those services unless the Industrial Center already has the same, Lessor already provides the services, or Lessor has agreed elsewhere in this Lease to provide the
same or some of them. 
 (d) Lessee’s Share of Common Area Operating Expenses shall be payable by Lessee within thirty (30) days
after a reasonably detailed statement of actual expenses is presented to Lessee by Lessor. At Lessor’s option, however, an amount may be estimated by Lessor from time to time of Lessee’s Share of annual Common Area Operating Expenses and
the same shall be payable monthly or quarterly, as Lessor shall designate, during each 12-month period of the Term, on the same day as the Base Rent is due hereunder. Lessor shall deliver to Lessee, within one hundred and twenty (120) days
after the expiration of each calendar year or as soon thereafter as practicable, a reasonably detailed statement showing Lessee’s Share of the actual Common Area Operating Expenses incurred during the preceding year. If Lessee’s payments
under this Subparagraph 4.2 (d) during said preceding year exceed Lessee’s Share as indicated on said statement, Lessor shall credit the amount of such over-payment against Rent next becoming due. If Lessee’s payments under this
Subparagraph 4.2 (d) during said preceding year were less than Lessee’s Share as indicated on said statement, Lessee shall pay to Lessor the amount of the deficiency within thirty (30) days after delivery by Lessor to Lessee of said
statement. Lessor’s estimate of Common Area Operating Expenses for the Industrial Center for the 2010 calendar year is $0.29 per rentable square foot. 

(e) After delivery to Lessor of at least thirty (30) days prior written notice, Lessee, at its sole cost and expense through any
accountant designated by it, shall have the right to examine and/or audit the books and records evidencing such expenses for the previous one (1) calendar year, during Lessor’s reasonable business hours but not more frequently than once
during any calendar year. Lessee may not compensate any such accountant on a contingency fee basis. The results of any such audit (and any negotiations between the parties related thereto) shall be maintained strictly confidential by Lessee and its
accounting firm and shall not be disclosed, published or otherwise disseminated to any other party other than to Lessor and its authorized agents or the Lessee’s employees, accountants, real estate advisors, financial advisors and attorneys and
as may be required by law or in any litigation or dispute arising out of such audit. Lessor and Lessee each shall use its commercially reasonable efforts to cooperate in such negotiations and to promptly resolve any discrepancies between Lessor and
Lessee in the accounting of such expenses. 
 (f) “Common Area Operating Expenses” shall not include and Lessee shall in no event
have any obligation to perform or to pay directly, or to reimburse Lessor for, all or any portion of the following repairs, maintenance, improvements, replacements, premiums, claims, losses, fees, charges, costs and expenses (collectively,
“Costs”): (a) Costs occasioned by the act, omission or violation of any Applicable Law by Lessor, any other occupant of the Industrial Center, or their respective agents, employees or contractors; (b) Costs occasioned by
casualties or by the exercise of the power of eminent domain, except for insurance deductibles as expressly provided in subparagraph (a) above and this subparagraph (f); (c) Costs to correct any construction defect in the Premises or the
Industrial Center existing as of the Effective Date or to comply with any Applicable Law applicable to the Premises or the Industrial Center in effect on the Effective Date: provided, however, that a change in the procedures for enforcing an
existing law will be the equivalent of a new law; (d) Costs of any renovation, improvement, painting or redecorating of any portion of the Industrial Center for any other lessee of the Industrial Center or for any other building in the
Industrial Center (except if such renovation, improvement, painting or redecorating is part of a program to reasonably renovate the entire Industrial Center, including the Building); (e) Costs incurred in connection with negotiations or
disputes with any other occupant of the Industrial Center and Costs arising from the violation by Lessor or any other occupant of the Industrial Center of the terms and conditions of any lease or other agreement; (f) insurance Costs for
coverage not customarily paid by tenants of similar projects in the vicinity of the Premises and increases in insurance Costs caused by the activities of another occupant of the Industrial Center and insurance deductibles in excess of $50,000 per
event of loss: (g) Costs incurred in connection with the presence of any Hazardous Substance, except to the extent caused by the release or emission of the Hazardous Substance in question by Lessee; (h) interest, charges and fees incurred
on debt; (i) expense reserves; (j) Costs which could properly be capitalized under sound accounting principles consistent with those generally used by sophisticated commercial landlords in the San Diego area, except to the extent amortized
over the useful life of the capital item in question; (k) wages, compensation, and labor burden for any employee not stationed on the Industrial Center on a full-time basis (provided, that if any employees of Lessor provide services for more
than one building or project of Lessor, then a prorated portion of such employees’ wages, benefits and taxes shall be included in Common Area Operating Expenses based on the portion of 

  
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their working time devoted to the Industrial Center) or any fee, profit or compensation retained or paid to a third party manager by Lessor or its affiliates for management and administration of
the Industrial Center in excess of 4% of the gross revenues of the Industrial Center; (l) any items for which Lessor is reimbursed by insurance or otherwise compensated, including direct reimbursement by any other lessee; or (m) the cost
of replacing the structural portions of the roof of the Building (excluding the roof membrane) or the roof of any other building in the Industrial Center. 

5. Security Deposit. Lessee shall deposit with Lessor upon Lessee’s execution hereof the Security Deposit set forth in Paragraph
1.8 of the Basic Provisions as security for Lessee’s faithful performance of Lessee’s obligations under this Lease. If Lessee Defaults under this Lease (as defined in Paragraph 13.1), Lessor may use, apply or retain all or any portion of
said Security Deposit for the payment of any amount due Lessor or to reimburse or compensate Lessor for any liability, cost, expense, loss or damage (including attorneys fees) which Lessor may suffer or incur by reason thereof. If Lessor uses or
applies all or any portion of said Security Deposit, Lessee shall within ten (10) days after written request therefore deposit monies with Lessor sufficient to restore said Security Deposit to the full amount required by this Lease. Lessor
shall not be required to keep all or any part of the Security Deposit separate from its general accounts. Lessor shall, at the expiration or earlier termination of the Term hereof and after Lessee has vacated the Premises, return to Lessee (or, at
Lessor’s option, to the last assignee, if any, of Lessee’s interest herein), that portion of the Security Deposit not used or applied by Lessor. Unless otherwise expressly agreed in writing by Lessor, no part of the Security Deposit shall
be considered to be held in trust, to bear interest or other increment for its use, or to be prepayment for any monies to be paid by Lessee under this Lease. Lessee hereby waives (i) California Civil Code Section 1950.7, as amended or
recodified from time to time, and any and all other laws, rules and regulations, now or hereafter in force, applicable to security deposits in the commercial context (“Security Deposit Laws”), and (ii) any and all rights, duties and
obligations either party may now or, in the future, will have relating to or arising from the Security Deposit Laws. Notwithstanding anything to the contrary contained herein, the security deposit may be retained and applied by Lessor (a) to
offset Rent (as defined in Section 4.1) which is unpaid either before or after the termination of this Lease, and (b) against other damages suffered by Lessor before or after the termination of this Lease, whether foreseeable or
unforeseeable, caused by the act or omission of Lessee or any officer, employee, agent or invitee of Lessee. 
 The Security Deposit, or so
much thereof as has not theretofore been applied by Lessor, shall be returned, without payment of interest or other increment for its use, to Lessee (or, at Lessor’s option, to the last assignee, if any, of Lessee’s interest hereunder) at
the expiration of the Term hereof, and after Lessee has vacated the Premises. 
 6. Use. 

6.1 Use. Lessee shall use and occupy the Premises only for the Permitted Use set forth in Paragraph 1.9 of the Basic Provisions, or any
other legal use, which is reasonably comparable thereto, and for no other purpose without Lessor’s consent. Lessee shall, at its expense, obtain any governmental permits or approvals required for the Permitted Use. The obtaining of any such
permits or approvals is not a condition to any of Lessee’s obligations under this Lease. Lessee acknowledges that neither Lessor nor Lessor’s agent has made any representation or warranty, whether express or implied, as to the Premises,
including, without limitation, the suitability of the Premises for the conduct of Lessee’s business. Lessee has been advised by Lessor to conduct its own investigation of the suitability of the Premises for Lessee’s intended use,
including, without limitation, a careful inspection of the Premises, a review of all applicable laws and ordinances, and inquiries of all applicable government agencies before executing this Lease. Lessee shall not use or permit the use of the
Premises in a manner that is unlawful, creates waste or a nuisance, or that unreasonably disturbs owners and/or occupants of, or causes damage to the Premises or neighboring premises or properties. Lessee further covenants and agrees that it shall
not use, or suffer or permit any person or persons to use, the Premises in violation of the laws of the United States of America, the State of California, or the ordinances, regulations or requirements of the local municipal or county governing body
or other lawful authorities having jurisdiction over the Building. Lessee shall comply with all recorded covenants, conditions, and restrictions, and the provisions of all ground or underlying leases, now or hereafter affecting the Real Property if
Lessor provides Lessee with a copy thereof. Lessor acknowledges that Lessee will maintain products in the Premises which are required from time to time for its business in customary amounts, which products contain chemicals which are categorized as
Hazardous Substances. Lessor agrees that the use of such products in the Premises in compliance with all applicable laws shall not be a violation by Lessee of this Lease. 

6.2 Hazardous Substances. 

(a) Reportable Uses Require Consent. The term “Hazardous Substance” as used in this Lease shall mean any product,
substance, chemical, material or waste whose presence, nature, quantity and/or intensity of existence, use, manufacture, disposal, transportation, spill, release or effect, either by itself or in combination with other materials expected to be on
the Premises, is either: (i) potentially injurious to the public health or the environment, or the Premises; (ii) regulated or monitored by any environmental laws; or (iii) a basis for potential liability of Lessor to any governmental
agency or third party under any applicable environmental statute or common law theory related to environmental laws. Hazardous Substance shall include, but not be limited to, hydrocarbons, petroleum, gasoline, crude oil or any products or
by-products thereof. Lessee shall not engage in any activity in or about the Premises, which constitutes a Reportable Use (as hereinafter defined) of Hazardous Substances without notice to Lessor (posted notice at the Premises shall be sufficient
for compliance with subparagraph (iii) below) and compliance in a timely manner (at 

  
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Lessee’s sole cost and expense) with all Applicable Requirements (as defined in Paragraph 6.3). “Reportable Use” shall mean (i) the installation or use of any above
or below ground storage tank, (ii) the generation, possession, storage, use, transportation, or disposal of a Hazardous Substance that requires a permit from, or with respect to which a report, notice, registration or business plan is required
to be filed with, any governmental authority, and (iii) the presence in, on or about the Premises of a Hazardous Substance with respect to which any Applicable Laws require that a notice be given to persons entering or occupying the Premises or
neighboring properties. Notwithstanding the foregoing, Lessee may, without Lessor’s prior consent, but upon notice to Lessor and in compliance with all Applicable Requirements. use any ordinary and customary materials reasonably required to be
used by Lessee in the normal course of the Permitted Use. Lessor acknowledges that Lessee will be generating, storing and/or disposing of Biohazardous Waste (as hereinafter defined) at the Premises in connection with Lessee’s operation of the
Permitted Use and that such Biohazardous Waste may include Hazardous Substances. In addition to Lessee’s obligations under this Section 6.2 with respect to any Biohazardous Waste which is a Hazardous Substance, Lessee shall comply with the
provisions of Section 7.5 in connection with its generation, storage and disposal of Biohazardous Waste at the Premises. 

(b) Duty to Inform Lessor. If Lessee knows, or has reasonable cause to believe, that a Hazardous Substance has come to be
located in, on, under or about the Premises or the Building, other than as previously consented to by Lessor, Lessee shall immediately give Lessor written notice thereof, together with a copy of any statement, report, notice, registration,
application, permit, business plan, license, claim, action, or proceeding given to, or received from, any governmental authority or private party concerning the presence, spill, release, discharge of, or exposure to, such Hazardous Substance
including but not limited to all such documents as may be involved in any Reportable Use involving the Premises. Lessee shall not cause or permit its agents, employees, contractors or invitees to cause any Hazardous Substance to be spilled or
released in, on, under or about the Premises (including, without limitation, through the plumbing or sanitary sewer system). 

(c) Indemnification. Lessee shall indemnify, protect, defend and hold Lessor (with counsel approved by Lessor), its directors,
officers, agents, partners, members, employees, lenders and ground lessor, if any, and the Premises, harmless from and against any and all damages, liabilities, judgments, costs, claims, liens, expenses, penalties, loss of permits and
attorneys’ and consultants’ fees arising out of or involving any (i) Hazardous Substance brought onto the Premises by or for Lessee or by anyone under Lessee’s control or with Lessee’s consent or (ii) the breach of any
term, condition, representation or warranty contained in this Paragraph 6. Lessee’s obligations under this Subparagraph 6.2 (c) shall include, but not be limited to, the effects of any contamination or injury to person, property or the
environment created or suffered by Lessee, and the cost of investigation (including consultants’ and attorneys’ fees and testing), removal, remediation, restoration and/or abatement thereof, or of any contamination therein involved, and
shall survive the expiration or earlier termination of this Lease. 
 (d) Exculpation of Lessor. Other lessees of the
Industrial Center may be using, handling or storing certain Hazardous Substances in connection with such lessees’ use of their premises. The failure of another lessee to comply with applicable laws and procedures could result in a release of
Hazardous Substances and contamination to the Industrial Center, or any part thereof or the soil and ground water thereunder. In the event of such release, the lessee responsible for the release, and not Lessor, shall be solely responsible for any
claim, damage or expense incurred by Lessee by reason of such contamination. Lessee waives any rights it may have to later assert that the foregoing release does not cover unknown claims. Lessee and anyone claiming by, through or under Lessee hereby
fully and irrevocably releases Lessor, its partners and their respective employees, officers, directors, representatives, agents, successors and assigns from any and all claims that it may now have or hereafter acquire against such persons and
entities for any cost, loss, liability, damage. expense, demand, action or cause of action arising from or related to any Hazardous Substance release or contamination to the Industrial Center by another lessee at the Industrial Center.
Notwithstanding the foregoing, this Section 6.2(d) shall not limit any obligation of Lessor under this Lease to remediate any Hazardous Substances released by other lessees if Lessor is required to perform such remediation by Applicable Laws or
Lessor’s liability to Lessee for any breach or violation of this Lease by Lessor. 
 (e) Environmental Questionnaire
Disclosure. Prior to the execution of this Lease, Lessee shall complete, execute and deliver to Lessor a Hazardous Substances Survey Form in the form of Exhibit G attached hereto (“Survey Form”), and Lessee shall
certify to Lessor that all information contained in the Survey Form as true and correct to the best of Lessee’s knowledge and belief. The completed Survey Form shall be deemed incorporated into this Lease for all purposes, and Lessor shall be
entitled to rely on the information contained therein. Within thirty (30) days following receipt by Lessee of a written request therefore from Lessor (which request shall not be made more often than annually), Lessee shall disclose to Lessor in
writing the names and amounts of all Hazardous Substances, or any combination thereof, which were stored, generated, used or disposed of on, under or about the Premises for the twelve (12) month period prior to and after each such request, or
which Lessee intends to store, generate, use or dispose of on, under or about the Premises. At Lessor’s option, Lessee’s disclosure obligation under this Subparagraph shall include the requirement that Lessee update. execute and deliver to
Lessor the Survey Form, as Lessor may modify the same from time to time. 
 6.3 Lessee’s Compliance with
Requirements. Lessee shall, at Lessee’s sole cost and expense, fully, diligently and in a timely manner, comply with all “Applicable Requirements,” which term is used in this Lease to mean all laws, rules, regulations,
ordinances, directives. covenants, easements and restrictions of record, permits, the requirements of any applicable  

  
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fire insurance underwriter or rating bureau, relating in any manner to the Premises (including but not limited to matters pertaining to (i) industrial hygiene, (ii) environmental
conditions on, in, under or about the Premises, including soil and groundwater conditions, and (iii) the use, generation, manufacture, production, installation, maintenance, removal, transportation, storage, spill, or release of any Hazardous
Substance), now in effect or which may hereafter come into effect. Lessee shall, within five (5) days after receipt of Lessor’s written request, provide Lessor with copies of all documents and information, including but not limited to
permits, registrations, manifests, applications, reports and certificates, evidencing Lessee’s compliance with any Applicable Requirements specified by Lessor, and shall immediately upon receipt, notify Lessor in writing (with copies of any
documents involved) of any actual claim, notice, citation, warning, complaint or report pertaining to or involving failure by Lessee or the Premises to comply with any Applicable Requirements. 

6.4 Inspection; Compliance with Law. Lessor, Lessor’s agents, employees, contractors and designated representatives, and
the holders of any mortgages, deeds of trust or ground leases on the Premises (“Lenders”) shall have the right subject to the restrictions in Paragraph 32 of this Lease, to enter the Premises at any time in the case of an emergency,
and otherwise at reasonable times, for the purpose of inspecting the condition of the Premises and for verifying compliance by Lessee with this Lease and all Applicable Requirements, and Lessor shall be entitled to employ experts and/or consultants
in connection therewith to advise Lessor with respect to Lessee’s activities, including but not limited to Lessee’s installation, operation, use, monitoring, maintenance, or removal of any Hazardous Substance on or from the Premises. The
costs and expenses of any such inspections shall be paid by the party requesting same, unless a Default or Breach of this Lease by Lessee or a violation of Applicable Requirements or a contamination. caused or materially contributed to by Lessee, is
found to exist or to be imminent, or unless the inspection is requested or ordered by a governmental authority as the result of any such existing or imminent violation or contamination. In such case, Lessee shall upon request reimburse Lessor or
Lessor’s Lender, as the case may be, for the costs and expenses of such inspections. 
 6.5 Lessor’s
Representation. Lessor represents to Lessee (which representation is made without any investigation or inquiry) that it has no actual knowledge concerning the existence of (a) any Hazardous Substances on or about the Premises, the Building
or the Common Areas or the soil, surface water or groundwater thereof, except as disclosed in the Environmental Report (as hereinafter defined), or (b) any underground storage tanks at the Industrial Center. Such representation is based solely
on, and Lessor’s actual knowledge is limited to, the information contained in that certain Phase 1 Environmental Site Assessment dated August 31, 2009, prepared by Occupational Services, Inc. under its Report No. 090831-02 (the
“Environmental Report”), a copy of which has been provided to Lessee. As of the Effective Date, Lessor further represents to Lessee that Lessor has not received written notice of any pending action, proceeding or claim relating to
the existence of Hazardous Substances at the Industrial Center. Under no circumstance shall Lessee be liable for any losses, costs, claims, liabilities and damages (including attorneys’ and consultants’ fees) of every type and nature,
directly or indirectly arising out of or in connection with any Hazardous Substances present at any time on or about the Industrial Center, or the soil, air, improvements, groundwater or surface water thereof, or the violation of any laws, orders or
regulations, relating to any such Hazardous Substance, except to the extent that any of the foregoing actually results from the release or emission of Hazardous Substances by Lessee or its agents, employees or invitees. 

7. Maintenance, Repairs, Utility Installations, Trade Fixtures and Alterations. 

7.1 Lessee’s Obligations. 

(a) Subject to the provisions of Paragraphs 2.2 (Condition), 2.3 (Compliance with Covenants, Restrictions and Building Code), 7.2
(Lessor’s Obligations), 9 (Damage or Destruction), and 14 (Condemnation), Lessee shall, at Lessee’s sole cost and expense and at all times, keep the Premises and every part thereof in good order, condition and repair (whether or not such
portion of the Premises requiring repair, or the means of repairing the same, are reasonably or readily accessible to Lessee, and whether or not the need for such repairs occurs as a result of Lessee’s use, any prior use, the elements or the
age of such portion of the Premises), ordinary wear and tear and damage by casualty excepted, including, without limiting the generality of the foregoing, all equipment or facilities specifically serving the Premises, such as plumbing, heating, air
conditioning, ventilating, electrical, lighting facilities, boilers, fired or unfired pressure vessels, fire hose connections if within the Premises, fixtures, interior walls, interior surfaces of exterior walls, ceilings, floors windows, doors,
plate glass, and skylights, but excluding any items which are the responsibility of Lessor pursuant to Paragraph 7.2 below. Lessee, in keeping the Premises in good order, condition and repair, shall exercise and perform good maintenance practices.
Lessee’s obligations shall include restorations, replacements or renewals when necessary to keep the Premises and all improvements thereon or a part thereof in good order, condition and state of repair, ordinary wear and tear and damage by
casualty excepted. Notwithstanding anything to the contrary in this Lease, Lessor shall perform and construct, and Lessee shall have no responsibility to perform or construct, any repair, maintenance or improvements (a) subject to the waiver of
subrogation set forth in Paragraph 8.7, arising from the negligence, willful misconduct or breach of this Lease by Lessor or its agents, employees or contractors, and (b) covered by any warranty held by Lessor. 

(b) Lessee shall, at Lessee’s sole cost and expense, procure and maintain a contract, with copies to Lessor, in customary form and
substance for and with a contractor specializing and experienced in the inspection, maintenance and service of the heating, air conditioning and ventilation for the Premises. However, Lessor reserves the right, upon notice to Lessee, to procure and
maintain a reasonable and competitively priced contract for the heating, air conditioning and ventilating systems, and if Lessor so elects, Lessee shall reimburse Lessor, upon demand, for the cost thereof. 

  
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 (c) If Lessee Breaches Lessee’s obligations under this Paragraph 7.1, Lessor may enter upon
the Premises after ten (10) days’ prior written notice to Lessee (except in the case of an emergency, in which case no notice shall be required), perform such obligations on Lessee’s behalf, and put the Premises in good order,
condition and repair, in accordance with Paragraph 13.2 below. 
 (d) Subject to Lessee’s indemnification of Lessor as set forth in
Paragraph 8.8 below, and without relieving Lessee of liability resulting from Lessee’s failure to exercise and perform good maintenance practices, if any capital replacements (as determined under Lessor’s sound accounting principles)
(“Capital Replacements”) are required or necessary for operation of the Premises (for example, replacement of an HVAC unit, sprinkler system or any other capital item, but excluding any capital items installed in the Premises by
Lessee), at Lessee’s written election to Lessor, Lessor shall complete such Capital Replacement, provided that the cost of such Capital Replacement shall be amortized on a straight-line basis over its useful life according to sound accounting
principles consistent with those generally used by sophisticated commercial landlords in the San Diego area, together with interest at 8% per annum on the unamortized balance, and such amortization shall be reimbursed by Lessee to Lessor on a
monthly basis during the Term on the date on which Base Rent is due. Notwithstanding the foregoing, Lessee shall complete any Capital Replacement, at Lessee’s sole cost and expense, that is required as a result of Lessee’s particular use
of, or improvements to, the Premises. 
 7.2 Lessor’s Obligations. Subject to the provisions of Paragraphs 2.2
(Condition), 2.3 (Compliance with Covenants, Restrictions and Building Code), 4.2 (Common Area Operating Expenses), 6 (Use), 7.1 (Lessee’s Obligations), 9 (Damage or Destruction) and 14 (Condemnation), and subject to the reimbursement
requirements of Paragraph 4.2, Lessor, shall keep in good order. condition and repair the foundations, exterior walls, structural condition of interior bearing walls, roof, fire sprinkler and/or standpipe and hose (if located in the Common Areas) or
other automatic fire extinguishing system including fire alarm and/or smoke detection systems and equipment, fire hydrants, parking lots, walkways, parkways, driveways, landscaping, fences, signs and utility systems serving the Common Areas and all
parts thereof, as well as providing the services for which there is a Common Area Operating Expense pursuant to Paragraph 4.2. Lessor shall not be obligated to maintain, repair or replace windows, doors or plate glass of the Premises. Lessee
expressly waives the benefit of any statute now or hereafter in effect which would otherwise afford Lessee the right to make repairs at Lessor’s expense or to terminate this Lease because of Lessor’s failure to keep the Building,
Industrial Center or Common Areas in good order, condition and repair. 
 7.3 Utility Installations, Trade Fixtures,
Alterations. 
 (a) Definitions; Consent Required. The term “Utility Installations” is used in this
Lease to refer to all air lines, power panels, electrical distribution, security, fire protection systems, communications systems, lighting fixtures, heating, ventilating and air conditioning equipment, plumbing, and fencing in, on or about the
Premises. The term “Trade Fixtures” shall mean Lessee’s machinery and equipment, furniture and other personal property which can be removed without doing material, structural damage to the Premises, including, without limitation, all
fermentors, chemical hoods, biological hoods and purification equipment. The term “Alterations” shall mean any modification of the improvements on the Premises, other than Utility Installations or Trade Fixtures, but excluding the
Leasehold Improvements. “Lessee-Owned Alterations and/or Utility Installations” are defined as Alterations and/or Utility Installations made by Lessee that are not yet owned by Lessor pursuant to Subparagraph 7.4 (a). Except as
provided herein. Lessee shall not make nor cause to be made any Alterations or Utility Installations in, on, under or about the Premises without Lessor’s prior written consent. 

(b) Consent. Any Alterations or Utility Installations that Lessee shall desire to make and which require the consent of the
Lessor shall be presented to Lessor in written form with detailed plans. All consents to Alterations or Utility Installations given by Lessor, whether by virtue of Subparagraph 7.3 (a) or by subsequent specific consent, shall be deemed
conditioned upon: (i) Lessee’s acquiring all applicable permits required by governmental authorities; (ii) the furnishing of copies of such permits together with a copy of the plans and specifications for the Alteration or Utility
Installation to Lessor prior to commencement of the work thereon; and (iii) the compliance by Lessee with all conditions of said permits in a prompt and expeditious manner. Any Alterations or Utility Installations by Lessee during the Term of
this Lease shall be done in a good and workmanlike manner, with good and sufficient materials, and be in compliance with all Applicable Requirements. Lessor’s approval of the plans, specifications and working drawings for Lessee’s
Alterations or Utility Installations shall create no responsibility or liability on the part of Lessor for their completeness, design sufficiency, or compliance with all laws, rules and regulations of governmental agencies or authorities. All work
with respect to any Alterations or Utility Installations must be done in a good and workmanlike manner and diligently prosecuted to completion to the end that the Premises shall at all times be a complete unit except during the period of work. In
performing the work of any such Alterations or Utility Installations, Lessee shall have the work performed in such manner as not to obstruct access to the common areas for any other lessee of the Industrial Center, and as not to obstruct the
business of Lessor or other lessees in the Industrial Center, or interfere with the labor force working in the Building or the Industrial Center. In the event that Lessee makes any Alterations or Utility Installations, Lessee agrees to carry
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insurance in an amount approved by Lessor covering the construction of such Alterations or Utility Installations, and such other insurance as Lessor may reasonably require, it being understood
and agreed that all of such Alterations or Utility Installations shall be insured by Lessee pursuant to Article 8 of this Lease immediately upon completion thereof. Upon completion of any Alterations or Utility Installations, Lessee agrees to cause
a Notice of Completion to be recorded in the office of the Recorder of the county in which the Building is located in accordance with Section 3093 of the Civil Code of the State of California or any successor statute, and Lessee shall deliver
to Lessor a reproducible copy of the “as built” drawings, and specifications therefor of the Alterations or Utility Installations. Lessor may (but without obligation to do so) condition its consent to any requested Alteration or Utility
Installation that costs One Hundred Thousand Dollars ($100,000.00) or more upon Lessee’s providing Lessor with a lien and completion bond in an amount equal to one and one-half times the estimated cost of such Alteration or Utility
Installation. Lessee shall pay to Lessor all of Lessor’s actual and reasonable costs incurred in conjunction with the review of Lessee’s proposed Alterations or Utility Installations within fifteen (15) days of Lessee’s receipt
of an invoice therefore (not to exceed $5,000.00). Notwithstanding the foregoing, Lessee shall have the right without Lessor’s consent but upon ten (10) business days’ prior notice to Lessor to make non-structural Alterations to the
Premises in accordance with the terms of this Lease, provided that such Alterations do not (i) affect the exterior of the Premises, the Building or the Industrial Center (nor may such Alterations be visible from the exterior of the Building),
including the Exterior Equipment Area, (ii) adversely affect the Premises’ electrical, ventilation, plumbing, elevator, mechanical, air conditioning or any other systems therein, or (iii) exceed $50,000 per calendar year. 

(c) Lien Protection. Lessee shall pay when due all claims for labor or materials furnished or alleged to have been furnished to
or for Lessee at or for use on the Premises, which claims are or may be secured by any mechanic’s or materialmen’s lien against the Premises or any interest therein. Lessee shall give Lessor not less than ten (10) days’ notice
prior to the commencement of any work in, on, or about the Premises, and Lessor shall have the right to post notices of non-responsibility in or on the Premises as provided by law. If Lessee shall, in good faith, contest the validity of any such
lien, claim or demand, then Lessee shall, at its sole expense, defend and protect itself, Lessor and the Premises against the same and shall pay and satisfy any such adverse judgment that may be rendered thereon before the enforcement thereof
against the Lessor or the Premises. If Lessor shall require, Lessee shall furnish to Lessor a surety bond satisfactory to Lessor in an amount equal to one and one-half times the amount of such contested lien claim or demand, indemnifying Lessor
against liability for the same, as required by law for the holding of the Premises free from the effect of such lien or claim. In addition, Lessor may require Lessee to pay Lessor’s attorneys’ fees and costs in participating in such action
if Lessor shall decide it is to its best interest to do so. 
 7.4 Ownership, Removal, Surrender, and Restoration. 

(a) Ownership. Subject to Lessor’s right to require their removal and to cause Lessee to become the owner thereof as
hereinafter provided in this Paragraph 7.4, all Alterations and Utility Installations made to the Premises by Lessee shall be the property of and owned by Lessor, but considered a part of the Premises. Unless otherwise instructed per Subparagraph
7.4 (b) hereof, all Alterations and Utility Installations shall, at the expiration or earlier termination of this Lease, automatically and without further action on the part of Lessor, become the property of Lessor and remain upon the Premises
and be surrendered with the Premises by Lessee. Notwithstanding anything to the contrary in this Lease, all Trade Fixtures shall be the property of Lessee and may be altered, removed and replaced by Lessee at any time during the Lease Term without
Lessor’s consent. 
 (b) Removal. Unless otherwise agreed in writing, Lessor may require that any or all
Lessee-Owned Alterations or Utility Installations be removed by the expiration or earlier termination of this Lease, notwithstanding that Lessor may have consented to their installation. Concurrently with Lessee’s request for consent, Lessee
may request that Lessor determine whether such Lessee-Owned Alterations or Utility Installations will be required to be so removed and if Lessor does not require such removal when consent is given, Lessee shall not be obligated to remove the
Lessee-Owned Alterations or Utility Installations at the expiration or earlier termination of this Lease. Lessor may require the removal at any time of all or any part of any Alterations or Utility Installations made without the required consent of
Lessor. Notwithstanding anything to the contrary in this Lease, in no event shall Lessee be required to remove the Leasehold Improvements. 

(c) Surrender/Restoration. Lessee shall surrender the Premises by the end of the last day of the Term or any earlier
termination date, clean and free of debris and in good operating order, condition and state of repair (including, but not limited to, all lights, ballasts, and lenses are operational; missing or damaged dock bumpers, levelers, seals, locks, and
lights are repaired or replaced; all racking bolts and other protrusions are removed from the floor and patched with epoxy; and all floor cracks Y4 inch wide or larger are filled with epoxy), ordinary wear and tear, casualty, condemnation, Leasehold
Improvements, Alterations and Utility Installations that Lessee is not required to remove excepted. Except as otherwise agreed or specified herein, the Premises, as surrendered, shall include the Alterations and Utility Installations. The obligation
of Lessee shall include the repair of any damage occasioned by the installation, maintenance or removal of Lessee’s Trade Fixtures, furnishings, equipment, and Lessee-Owned Alterations and Utility Installations, as well as the removal of any
storage tank (other than the air compressor tank) installed by or for Lessee, and the removal, replacement, or remediation of any soil, material or ground water contaminated by Lessee, all as may then be required by Applicable Requirements and/or
good practice. Lessee’s Trade Fixtures shall remain the property of Lessee and shall be removed by Lessee subject to its obligation to repair and restore the Premises per this Lease. 

  
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 7.5 Biohazardous Waste. 

(a) Definition. The term “Biohazardous Waste” shall mean the types of waste described in section 117635 of
California’s Health and Safety Code and any similar type of waste. 
 (b) Disposal of Biohazardous Waste. Lessee
hereby agrees, at Lessee’s sole expense, to dispose of its Biohazardous Waste in compliance with all federal, state and local laws, rules and regulations relating to the disposal of Biohazardous Waste and to dispose of the Biohazardous Waste in
a prudent and reasonable manner. Lessee shall not place any Biohazardous Waste in the Building’s refuse containers. 

(c) Duty to Inform Lessor. Within ten (10) days following Lessor’s written request, Lessee shall provide Lessor with
any information requested by Lessor concerning the existence, generation or disposal of Biohazardous Waste at the Premises, including, but not limited to, the following information: (a) the name, address and telephone number of the person or
entity employed by Lessee to dispose of its Biohazardous Waste, including a copy of any contract with said person or entity, (b) a list of each type of Biohazardous Waste generated by Lessee at the Premises and a description of how Lessee
disposes of said Biohazardous Waste, (c) a copy of any laws, rules or regulations in Lessee’s possession relating to the disposal of the Biohazardous Waste generated by Lessee, and (d) copies of any licenses or permits obtained by
Lessee in order to generate or dispose of said Biohazardous Waste. Lessee shall also immediately provide to Lessor (without demand by Lessor) a copy of any notice, registration, application, permit, or license received from any governmental
authority, or persons entering or occupying the Premises, concerning the presence, release, exposure or disposal of any Biohazardous Waste in or about the Premises or the Building. 

(d) Inspection; Compliance. Subject to compliance with laws and regulations governing the confidentiality of donor information
and medical records, Lessor and Lessor’s employees, agents, contractors and lenders shall have the right to enter the Premises at any time in the case of an emergency, and otherwise at reasonable times upon prior written notice to Lessee, for
the purpose of verifying compliance by Lessee with this Section 7.5. Lessor shall have the right to employ experts and/or consultants in connection with its examination of the Premises and with respect to the generation and disposal of
Biohazardous Waste on or from the Premises. The cost and expenses of any such inspection shall be paid by Lessor, unless it is determined that Lessee is not disposing of its Biohazardous Waste in a manner permitted by applicable law, in which case
Lessee shall immediately reimburse Lessor for the cost of such inspection. 
 8. Insurance; Indemnity. 

8.1 Lessor’s Insurance. At all times during the Term of this Lease, Lessor will purchase and maintain, as part of the
Common Area Operating Expenses, Commercial General Liability Insurance covering the Common Areas in such reasonable amounts and with such reasonable coverages as determined by Lessor and “causes of loss - special form” property insurance
covering the Building (excluding the Leasehold Improvements) and the Common Areas and Lessor’s equipment and furnishings against loss or damage resulting from fire and other insurable loss on a 100% replacement cost basis. Lessee acknowledges
that it shall not be a named insured on such policies and that it has no right to receive any proceeds from any such insurance policies carried by Lessor. Lessee further acknowledges that Lessor shall not be required to carry insurance covering
(1) Lessee-Owned Alterations and Utility Installations, Trade Fixtures and Lessee’s personal property; (2) Business Income Insurance against, or be responsible for, any loss suffered by Lessee due to interruption of Lessee’s
business from any cause; (3) loss to the Premises resulting from flood, earthquake, windstorm or hurricane; and (4) any other type of property. Lessee shall cooperate with Lessor’s insurance companies in the adjustment of any claims
for any damage to the Building. 
 8.2 Lessee’s Insurance. At all times during the Term of this Lease, Lessee will
purchase and maintain, at Lessee’s sole expense, the following insurance, in amounts not less than those specified below or such other amounts as Lessor may from time to time reasonably request, with insurance companies and on forms
satisfactory to Lessor. 
 (a) Commercial General Liability Insurance written on an I.S.O. “occurrence” form or its
equivalent covering the use, occupancy and maintenance of the Premises and all operations of Lessee. Such coverage shall include Premises Operations; Products - Completed Operations; Broad Form Property Damage; Blanket Contractual Liability;
Personal and Advertising Injury; Fire Legal Liability; Employees Named as Additional Insureds; and Severability. Limits for such coverage shall be Bodily Injury and Property Damage Combined Single Limit of $1,000,000 per Occurrence $2,000,000
General Aggregate, Products and Completed Operations Aggregate of $2,000,000, Personal and Advertising Injury of $1,000,000 Per Person/Organization subject to $2,000,000 General Aggregate, and Fire Legal Liability of $250,000. The policy shall
contain an endorsement specifically naming the following as additional insureds: (1) Lessor, (2) Westcore Properties, LLC, and (3) Wellcorp Properties, LLC, and their officers and employees (collectively, the “Additional
Insured Parties”), with respect to the Lessee’s use, occupancy or maintenance of the Premises. The amount of such insurance shall not limit Lessee’s liability nor relieve Lessee of any obligation hereunder. Each policy shall
insure Lessee’s performance of the indemnity provisions contained in this Lease. If Lessee’s liability insurance policy covers more than one location, Lessee shall obtain an “Aggregate Limits of Insurance (per location)”
endorsement. The policy shall also contain an endorsement amending the “Other Insurance” clause as follows: “The insurance afforded to Additional Insureds under this  

  
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policy is primary insurance and the insurer will not seek contribution from other insurance available to the Additional Insureds.” The policy shall contain a waiver of subrogation
endorsement. The policy shall provide defense expense in addition to the limit of liability stated in the policy. 
 (b) Umbrella Liability
Insurance to be excess over the Commercial General Liability, Automobile Liability and Employers’ Liability Insurance. The Umbrella Liability policy shall be written on an “occurrence” form with a limit of liability of One Million
Dollars ($1,000,000.00) and a Self-Insured Retention no greater than Ten Thousand Dollars ($10,000.00). The policy shall contain an endorsement naming the Additional Insured Parties as additional insureds following the form of the underlying
Commercial General Liability and Automobile Liability policies. The policy shall also contain an endorsement amending the “Other Insurance” clause as follows: “Subject to the terms and conditions of this policy, the insurance afforded
to Additional Insureds, (1) Lessor, (2) Westcore Properties, LLC, and (3) Wellcorp Properties, LLC under this policy shall be considered to be primary to any insurance they may have in force which also applies to a loss covered
hereunder and, further, the insurer shall not seek contribution from other insurance available to the Additional Insureds.” The policy shall contain a waiver of subrogation endorsement. 

(c) Commercial Property Insurance covering all Lessee’s furniture, fixtures, machinery, equipment, stock and any other personal property
owned and/or used in Lessee’s business and all leasehold improvements, whether made or acquired at the Lessee’s expense or Lessor’s expense, plate glass that is part of the Premises and any other property in the Premises that Lessee
is responsible for repairing or replacing under this Lease, in an amount equal to their full replacement cost without deduction for depreciation. At a minimum, such policy shall insure against destruction or damage by fire and other perils covered
on an ISO Causes of Loss - Special Form including wind and hurricane. Such policy shall further provide Replacement Cost Coverage, including earthquake sprinkler coverage. Such policy shall not contain a per occurrence deductible greater than Ten
Thousand Dollars ($10,000.00). Provided that this Lease has not been terminated, Lessee, with all reasonable speed, will use all proceeds of such insurance, so long as this Lease remains in effect, for rebuilding, repairing, replacing or otherwise
reinstating the Leasehold Improvements and all Alterations and Utility Installations made by Lessee in a good and substantial manner pursuant to applicable building laws and codes and the plan as shall have been approved in writing by Lessor. Lessee
will make up from its own funds any deficiency in such insurance proceeds. Further, the policy shall contain a provision specifically naming the Additional Insured Parties as additional insureds. 

(d) Business Income and/or Extra Expense Insurance in an amount sufficient to insure payment of Rent and all other expenses to be borne by
Lessee under this Lease, for a period of not less than Twelve (12) months, during any interruption of Lessee’s business by reason of the Premises or personal property being damaged by fire or other perils covered on an ISO Causes of Loss -
Special Form or its equivalent. In addition, such coverage shall be written on an Agreed Amount Basis. 
 (e) If reasonably required by
Lessor because of special environmental concerns regarding the Lessee’s operations, Pollution Legal Liability Insurance and/or Environmental Impairment Insurance covering claims for damage or injury caused by hazardous materials, including,
without limitation, bodily injury, wrongful death, property damage, including loss of use, removal, cleanup and restoration of work and materials necessary to return the premises and any other property of whatever nature located on the Premises to
their condition existing prior to the appearance of Lessee’s hazardous materials on the Premises. The policy shall contain a provision specifically naming the Additional Insured Parties as additional insureds. If such coverage is required,
Lessor shall determine limits of liability. 
 (f) Automobile Liability Insurance to include coverage for any owned, non-owned or hired
automobiles entering and exiting from the Premises and automobile contractual liability with limits of: $1,000,000 per Person/$1,000,000 per Accident—Bodily Injury; $1,000.000 per Accident - Property Damage; and Basic No-Fault coverage as
required by law or regulation if any, in the State in which the Premises is located. 
 (g) Workers’ Compensation coverage shall be
carried as required by law in the State in which the employees are hired and to further include: Voluntary Compensation Coverage and Other States’ Coverage, if applicable, with statutory limits for Workers’ Compensation and limits for
Employers’ Liability of: $1,000,000 Each Accident; $1,000,000 Disease - Policy Limit; and $1,000,000 Disease - Each Employee. The policy shall further contain an endorsement providing a waiver of subrogation in favor of the Additional Insured
Parties. 
 8.4 General Requirements. 

(a) Certificates of Insurance evidencing all such insurance and acceptable to the Lessor shall be filed with Lessor prior to occupancy of the
Premises and at least five (5) days prior to the expiration of the term of each policy thereafter. Such Certificates of Insurance must specifically show all the special policy conditions required in this Article including “additional
insured”, “waiver of subrogation”, “notice of cancellation”, and “primary insurance” wording applicable to each policy. Alternatively, a certified, true and complete copy of each properly endorsed policy may be
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 (b) All coverage shall be written by an admitted insurer in the State in which the Premises is
located with a current Best Rating of A. 
 (c) All insurance policies required hereunder shall be specifically endorsed to state that
coverages afforded under the policies will not be cancelled or allowed to expire for any reason until at least 30 days’ prior written notice has been mailed to the Lessor. The Certificate of Insurance for each policy must state that “the
issuing company will mail 30 days’ written notice of cancellation or modification to the certificate holder.” The words “endeavor to” and “failure to mail such notice shall impose no obligation for
liability . . .” are unacceptable and these two phrases must be crossed out if they appear in the printed certificate form. 

(d) Intentionally omitted. 

(e) Lessee shall not settle any claim or accept any proceeds in satisfaction of any claim involving damage to the Premises or liability of
Lessor without Lessor’s express prior written consent. 
 (f) Lessee may maintain the insurance required under this Paragraph under
blanket or umbrella policies, as applicable, issued to Lessee covering other properties owned or leased by Lessee; provided that the policies otherwise comply with this Paragraph and allocate to the Premises the coverage specified by this Paragraph,
without possibility of reduction or coinsurance penalty by reason of, or damage to, any other properties named therein, and if the insurance required by this Paragraph shall be effected by any such blanket or umbrella policies, Lessee shall furnish
to Lessor certified copies of policies with schedules thereto attached showing the amount of insurance afforded by such policies to the Premises. 

8.5 Adequacy of Coverage. Lessor, its agents and employees, make no representation that the limits of liability specified to be
carried by Lessee pursuant to this Paragraph are adequate to protect Lessee. If Lessee believes that any of such insurance coverage is inadequate. Lessee will obtain such additional insurance coverage as Lessee deems adequate, at Lessee’s sole
expense. 
 8.6 Reservation of Rights - Changes. Lessor hereby reserves the right to make reasonable changes at any
time (but not more often than one time per annum with any change to be effective at the time of Lessee’s annual renewal of its insurance policies) to the Insurance Requirements herein should new exposures be brought to light or new insurance
products become available during the Term of this Lease. Lessee shall add as additional insureds to the insurance policies required by this Paragraph such other persons as Lessor may from time to time reasonably require. 

8.7 Waiver of Subrogation. Notwithstanding anything to the contrary contained in this Lease, Lessee and Lessor each hereby
waives, on such party’s behalf and on behalf of any insurance carrier of such party, any claim which such party might otherwise have against the other party and the other party’s affiliates, arising out of loss or damage, including
consequential loss or damage, to any property of Lessee within the Premises, Building or the Industrial Center from any risk required to be insured against by such party under this Lease, without regard to the negligence of the party so released.
All of Lessor’s and Lessee’s repair and indemnity obligations under this Lease shall be subject to the waiver contained in this paragraph. 

8.8 Indemnity. Except for Lessor’s negligence, willful misconduct and/or breach of this Lease, Lessee shall indemnify,
protect, defend and hold harmless the Premises, Lessor and its agents, employees, officers, independent contractors, Lessor’s master or ground lessor, partners and Lenders, from and against any and all claims, loss of rents and/or damages,
costs, liens, judgments, penalties, loss of permits, attorneys’ and consultants’ fees, expenses and/or liabilities arising out of, involving, or in connection with, the occupancy of the Premises by Lessee, the conduct of Lessee’s
business, any act, omission or neglect of Lessee, its agents, contractors, employees or invitees, and out of any Default or Breach by Lessee in the performance in a timely manner of any obligation on Lessee’s part to be performed under this
Lease. The foregoing shall include, but not be limited to, the defense or pursuit of any claim or any action or proceeding involved therein, and whether or not (in the case of claims made against Lessor) litigated and/or reduced to judgment. In case
any action or proceeding be brought against Lessor by reason of any of the foregoing matters, Lessee, upon notice from Lessor, shall defend the same at Lessee’s expense by counsel reasonably satisfactory to Lessor and Lessor shall cooperate
with Lessee in such defense. Lessor need not have first paid any such claim in order to be so indemnified. Except to the extent caused by Lessee’s negligence, willful misconduct and/or breach of this Lease, Lessor shall indemnify, protect,
defend and hold harmless Lessee from all damages arising from Lessor’s negligence, willful misconduct or breach of this Lease. 

8.9 Exemption of Lessor from Liability. Except as set forth in Paragraph 8.8, Lessor shall not be liable for injury or damage to
the person or goods, wares, merchandise or other property of Lessee’s employees, contractors, invitees, customers, or any other person in or about the Premises, whether such damage or injury is caused by or results from fire, steam,
electricity, gas, water or rain, or from the breakage, leakage, obstruction or other defects of pipes, fire sprinklers, wires, appliances, plumbing, air conditioning or lighting fixtures, or from any other cause, whether said injury or damage
results from conditions arising upon the Premises or upon other portions of the Building of which the Premises are a part, from other sources or places, and regardless  

  
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of whether the cause of such damage or injury or the means of repairing the same is accessible or not. Lessor shall not be liable for any damages arising from any act or neglect of any other
lessee of Lessor nor from the failure by Lessor to enforce the provisions of any other lease in the Industrial Center. Notwithstanding Lessor’s negligence or breach of this Lease, Lessor shall under no circumstances be liable for injury to
Lessee’s business or for any loss of income or profit therefrom. 
 9. Damage or Destruction. 

9.1 Definitions. 

(a) “Premises Partial Damage” shall mean damage or destruction to the Premises, other than Lessee-Owned Alterations
and Utility Installations, the repair cost of which damage or destruction is less than seventy-five percent (75%) of the then Replacement Cost (as defined in Subparagraph 9.1 (d) of the Premises (excluding Lessee-Owned Alterations and
Utility Installations and Trade Fixtures) immediately prior to such damage or destruction. 
 (b) “Premises Total
Destruction” shall mean damage or destruction to the Premises, other than Lessee-Owned Alterations and Utility Installations, the repair cost of which damage or destruction is seventy-five percent (75%) or more the then Replacement
Cost of the Premises (excluding Lessee-Owned Alterations and Utility Installations and Trade Fixtures) immediately prior to such damage or destruction. In addition, damage or destruction to the Building, other than Lessee-Owned Alterations and
Utility Installations and Trade Fixtures of any lessees of the Building, the cost of which damage or destruction is seventy-five percent (75%) or more of the then Replacement Cost (excluding Lessee-Owned Alterations and Utility Installations
and Trade Fixtures of any lessees of the Building) of the Building shall, at the option of Lessor, be deemed to be Premises Total Destruction. 

(c) “Insured Loss” shall mean damage or destruction to the Premises, other than Lessee-Owned Alterations and Utility
Installations and Trade Fixtures, which was caused by an event required to be covered by the insurance described in Paragraph 8.1 irrespective of any deductible amounts or coverage limits involved, and where adequate insurance proceeds are available
to Lessor for the reconstruction of the Premises. 
 (d) “Replacement Cost” shall mean the cost to repair or
rebuild the improvements owned by Lessor at the time of the occurrence to their condition existing immediately prior thereto, including demolition, debris removal and upgrading required by the operation of applicable building codes, ordinances or
laws, and without deduction for depreciation. 
 (e) “Hazardous Substance Condition” shall mean the
occurrence or discovery of a condition involving the presence of, or a contamination by, a Hazardous Substance as defined in Subparagraph 6.2 (a), in, on or under the Premises. 

9.2 Premises Partial Damage - Insured Loss. If Premises Partial Damage occurs, and such damage or destruction is an Insured
Loss, then Lessor shall, at Lessor’s expense, repair such damage (but not Lessee’s Trade Fixtures or Lessee-Owned Alterations and Utility Installations) as soon as reasonably possible and this Lease shall continue in full force and effect.
Unless otherwise agreed, Lessee shall in no event have any right to reimbursement from Lessor for any funds contributed by Lessee to repair any such damage or destruction. Premises Partial Damage due to flood or earthquake shall be subject to
Paragraph 9.3 rather than this Paragraph 9.2, notwithstanding that there may be some insurance coverage, but the net proceeds of any such insurance shall be made available for the repairs if made by either Party. 

9.3 Partial Damage - Uninsured Loss. If Premises Partial Damage occurs and such damage or destruction is not an Insured Loss and
the cost to repair exceeds $250,000, then Lessor may at Lessor’s option, either (i) repair such damage as soon as reasonably possible at Lessor’s expense, in which event this Lease shall continue in full force and effect, or
(ii) give written notice to Lessee within sixty (60) days after receipt by Lessor of knowledge of the occurrence of such damage of Lessor’s desire to terminate this Lease as of the date sixty (60) days following the date of such
notice. In the event Lessor elects to give such notice of Lessor’s intention to terminate this Lease, Lessee shall have the right within ten (10) days after the receipt of such notice to give written notice to Lessor of Lessee’s
commitment to pay for the repair of such damage totally at Lessee’s expense and without reimbursement from Lessor. Lessee shall provide Lessor with the required funds or satisfactory assurance thereof within thirty (30) days following such
commitment from Lessee. In such event this Lease shall continue in full force and effect, and Lessor shall proceed to make such repairs as soon as reasonably possible after the required funds are available. If Lessee does not give such notice and
provide the funds or assurance thereof within in the times specified above, this Lease shall terminate as of the date specified in Lessor’s notice of termination. Notwithstanding the foregoing, if the cost to repair any damage to the Premises
does not exceed $250,000, then Lessor shall repair such damage as soon as reasonably possible at Lessor’s expense. 
 9.4
Total Destruction. Notwithstanding any other provision hereof, if Premises Total Destruction occurs (including any destruction required by any authorized public authority), and Lessee is prevented from utilizing the Premises and from deriving
any beneficial use therefrom, this Lease shall terminate sixty (60) days following the date of such Premises Total Destruction, whether or not the damage or destruction is an Insured Loss or was caused by a negligent or willful act of Lessee.

  
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 9.5 Damage Near End of Term. If at any time during the last six (6) months of
the Term of this Lease there is damage for which the cost to repair exceeds one month’s Base Rent, whether or not an Insured Loss, Lessor may, at Lessor’s option, terminate this Lease effective sixty (60) days following the date of
occurrence of such damage by giving written notice to Lessee of Lessor’s election to do so within thirty (30) days after the date of occurrence of such damage. Provided, however, if Lessee at that time has an exercisable option to extend
this Lease or to purchase the Premises, then Lessee may preserve this Lease by exercising such option on or before the earlier of (i) the date which is ten (10) days after Lessee’s receipt of Lessor’s written notice purporting to
terminate this Lease, or (ii) the day prior to the date upon which such option expires. If Lessee duly exercises such option during such period, Lessor shall, at Lessor’s expense repair such damage as soon as reasonably possible and this
Lease shall continue in full force and effect. If Lessee fails to exercise such option during such period, then this Lease shall terminate as of the date set forth in the first sentence of this Paragraph 9.5. 

9.6 Abatement of Rent; Lessee’s Remedies. 

(a) In the event of (i) Premises Partial Damage or (ii) Hazardous Substance Condition for which Lessee is not legally responsible,
the Base Rent, Common Area Operating Expenses and other charges, if any, payable by Lessee hereunder for the period during which such damage or condition, its repair, remediation or restoration continues, shall be abated in proportion to the degree
to which, in Lessor’s good faith reasonable business judgment, Lessee’s use of the Premises is impaired, but not in excess of proceeds from insurance required to be carried under Subparagraph 8.2 (d). Except for abatement of Base Rent,
Common Area Operating Expenses and other charges. if any, as aforesaid, all other obligations of Lessee hereunder shall be performed by Lessee, and Lessee shall have no claim against Lessor for any damage suffered by reason of any such damage,
destruction, repair, remediation or restoration. 
 (b) If Lessor is obligated to repair or restore the Premises under the
provisions of this Paragraph 9 and does not commence the repair or restoration of the Premises as soon as reasonably practicable (but in no event later than ninety (90) days after the occurrence of the casualty), then Lessee may, at any time
prior to the commencement of such repair or restoration, give written notice to Lessor and to any Lenders of which Lessee has actual notice of Lessee’s election to terminate this Lease on a date not less than thirty (30) days following the
giving of such notice. If Lessee gives such notice to Lessor and such Lenders and such repair or restoration is not commenced within thirty (30) days after receipt of such notice, this Lease shall terminate as of the date specified in said
notice. If Lessor or a Lender commences the repair or restoration of the Premises within thirty (30) days after the receipt of such notice, this Lease shall continue in full force and effect. “Commence” as used in this
Paragraph 9.6 shall mean the preparation of the required plans or the beginning of the actual work on the Premises, whichever occurs first. 

9.7 Lessee’s Termination Right. If Lessor does not elect to terminate this Lease under the terms of this Section 9,
but the damage required to be repaired by Lessor is not repaired within the period ending 270 days after the damage or destruction (the “270 Day Period”) (subject to extension for any delay caused by strikes, lockouts, labor disputes, acts
of God, inability to obtain services, labor or materials or reasonable substitutes therefor, governmental actions, civil commotions, fire or other casualty, and other causes beyond the reasonable control of Lessor (other than financial inability),
provided that in no event shall such extension exceed 90 days), then Lessee (subject to the provisions of this Paragraph 9.7), within thirty (30) days after the end of such 270 Day Period, may terminate this Lease by written notice to Lessor,
in which event this Lease shall terminate as of the date of receipt of the notice. Notwithstanding the foregoing, if Lessor is diligently proceeding to complete the repair of such damage, then Lessee shall not have the right to terminate this Lease
if, prior to the expiration of the 270 Day Period, Lessor, at Lessor’s sole option, gives written notice to Lessee that the repairs will be completed within thirty (30) days after the end of such 270 Day Period, and the repairs are
actually completed within such thirty (30) day period. If the repairs are not completed within thirty (30) days after the end of such 270 Day Period, then Lessee may terminate this Lease by written notice to the Lessor. Such notice of
termination shall be given within sixty (60) days after the end of such 270 Day Period, and shall be effective upon receipt thereof by Lessor. Notwithstanding the provisions of this Paragraph 9.7, Lessee shall have the right to terminate this
Lease under this Paragraph 9.7 only if there is no Breach then in effect. 
 9.8 Intentionally Deleted. 

9.9 Termination - Advance Payments. Upon termination of this Lease pursuant to this Paragraph 9, Lessor shall return to Lessee
any advance payment made by Lessee to Lessor and so much of Lessee’s Security Deposit as has not been or is not then required to be, used by Lessor under the terms of this Lease. 

9.10 Waiver of Statutes. Lessor and Lessee agree that the terms of this Lease shall govern the effect of any damage to or
destruction of the Premises and the Building with respect to the termination of this Lease and hereby waive the provisions of any present or future statute to the extent it is inconsistent herewith. 

  
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 10. Real Property Taxes. 

10.1 Payment of Taxes. Lessor shall pay the Real Property Taxes, as defined in Paragraph 10.2, applicable to the Industrial
Center, and except as otherwise provided in Paragraph 10.3, the Real Property Taxes shall be included in the calculation of Common Area Operating Expenses in accordance with the provisions of Paragraph 4.2. 

10.2 Real Property Tax Definition. As used herein, the term “Real Property Taxes” shall include any form of
real estate tax or assessment, general, special, ordinary or extraordinary, and any license fee, commercial rental tax, improvement bond or bonds, levy or tax (other than inheritance, personal income or estate taxes) imposed upon the Industrial
Center by any authority having the direct or indirect power to tax, including any city, state or federal government, or any school, agricultural, sanitary, fire, street, drainage, or other improvement district thereof, levied against any legal or
equitable interest of Lessor in the Industrial Center or any portion thereof, Lessor’s right to rent or other income therefrom, and/or Lessor’s business of leasing the Premises. The term “Real Property Taxes” shall also
include any tax, fee, levy, assessment or charge, or any increase therein, imposed by reason of events occurring, or changes in Applicable Law taking effect, during the Term of this Lease, including but not limited to a change in the ownership of
the Industrial Center or in the improvements thereon, the execution of this Lease, or any modification, amendment or transfer thereof, and whether or not contemplated by the Parties. In calculating Real Property Taxes for any calendar year, the Real
Property Taxes for any real estate tax year shall be included in the calculation of Real Property Taxes for such calendar year based upon the number of days, which such calendar year and tax year have in common. Each year, at Lessor’s election,
Lessor may protest real property assessments. In the event Lessor elects to protest a real property tax assessment, Lessor may utilize the services of a tax consultant to protest the real property tax assessment. If as a result of the protest, the
Real Property Taxes are lowered, and a tax consultant has been utilized in connection with the protest, Lessee agrees to pay, as additional rent during the Term, its prorated Lessee’s Share of all fees payable to tax consultants in the manner
set forth in this Lease, as long as there is a net benefit to Lessee from such lowering of Real Property Taxes. Notwithstanding anything to the contrary in this Lease, “Real Property Taxes” shall not include and Lessee shall not be
required to pay any portion of any tax or assessment expense or any increase therein (a) levied on Lessor’s rental income, unless such tax or assessment is imposed in lieu of real property taxes; (b) in excess of the amount which
would be payable if such tax or assessment expense were paid in installments over the longest permitted term; (c) imposed on land and improvements other than the Industrial Center; (d) attributable to Lessor’s net income, inheritance,
gift, transfer, estate or state taxes; or (e) resulting from the improvement of any of the Industrial Center for the sole use of other occupants. 

10.3 Additional Improvements. Common Area Operating Expenses shall not include Real Property Taxes specified in the tax
assessor’s records and work sheets as being caused by additional improvements placed upon the Industrial Center by other lessees or by Lessor for the exclusive enjoyment of such other lessees. Notwithstanding Paragraph 10.1 hereof, Lessee
shall, however, pay to Lessor at the time Common Area Operating Expenses are payable under Paragraph 4.2, the entirety of any increase in Real Property Taxes if assessed solely by reason of Alterations, Trade Fixtures or Utility Installations placed
upon the Premises by Lessee or at Lessee’s request. 
 10.4 Joint Assessment. If the Building is not separately
assessed, Real Property Taxes allocated to the Building shall be an equitable proportion of the Real Property Taxes for all of the land and improvements included within the tax parcel assessed, such proportion to be determined by Lessor from the
respective valuations assigned in the assessor’s work sheets or such other information as may be reasonably available. Lessor’s reasonable determination thereof, in good faith, shall be conclusive. 

10.5 Lessee’s Property Taxes. Lessee shall pay, prior to delinquency, all taxes assessed against and levied upon
Lessee-Owned Alterations and Utility Installations, Trade Fixtures, furnishings, equipment and all personal property of Lessee contained in the Premises or stored within the Industrial Center. When possible, Lessee shall cause its Lessee-Owned
Alterations and Utility Installations, Trade Fixtures, furnishings, equipment and all other personal property to be assessed and billed separately from the real property of Lessor. If any of Lessee’s said property shall be assessed with
Lessor’s real property, Lessee shall pay Lessor the taxes attributable to Lessee’s property within ten (10) days after receipt of a written statement setting forth the taxes applicable to Lessee’s property. 

11. Utilities; Rental Abatement Events. Lessee shall pay directly for all utilities and services supplied to the Premises,
including but not limited to electricity, telephone, security, gas, trash removal and cleaning of the Premises, together with any taxes thereon. Upon Lessor’s request, Lessee shall deliver to Lessor copies of all bills for separately metered
utilities supplied to the Premises for the past twelve (12) month period within thirty (30) days of Lessor’s request. As part of Lessor’s Work, Lessor shall cause all utilities to be separately metered to the Building prior to the
Commencement Date. Notwithstanding anything to the contrary contained in this Lease, if the Premises are rendered unusable for the normal conduct of Lessee’s business and Lessee, in fact, ceases to use and occupy such portion of the Premises
for the normal conduct of its business as a result of (a) Lessor’s failure to provide utilities or services as required by this Lease, or (b) the presence of Hazardous Substances in, on or around the Premises, the Building or the Industrial
Center which poses a material health risk to occupants of the Premises, and which was not brought into or onto the Premises, Building or Industrial Center by Lessee or Lessee’s employees, agents, contractors or invitees (an “Abatement
Event”), then Lessee shall give Lessor notice of such Abatement Event, and if such Abatement Event continues for seven (7) consecutive business days after Lessor’s receipt of any such notice (the “Eligibility Period”), then the
Base Rent and Lessee’s Share of Common Area 

  
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Operating Expenses shall be abated or reduced, as the case may be, after the expiration of the Eligibility Period for such time that Lessee continues to be so prevented from using, and does not
use, the Premises or a portion thereof, in the proportion that the rentable area of the portion of the Premises that Lessee is prevented from using, and does not use, bears to the total rentable area of the Premises; provided, however, in the event
that Lessee is prevented from using, and does not use, a portion of the Premises for a period of time in excess of the Eligibility Period and the remaining portion of the Premises is not sufficient to allow Lessee to effectively conduct its business
therein, and if Lessee does not conduct its business from such remaining portion, then for such time after expiration of the Eligibility Period during which Lessee is so prevented from effectively conducting its business therein, the Base Rent and
Lessee’s Share of Common Area Operating Expenses for the entire Premises shall be abated for such time as Lessee continues to be so prevented from using, and does not use, the Premises. If, however, Lessee reoccupies and conducts normal
business operations in any portion of the Premises during such period, the Rent allocable to such reoccupied portion, based on the proportion that the rentable area of such reoccupied portion of the Premises bears to the total rentable area of the
Premises, shall be payable by Lessee from the date Lessee reoccupies and conducts normal business operations in such portion of the Premises. Such right to abate Base Rent and Lessee’s Share of Common Area Operating Expenses in this Paragraph
11 shall be Lessee’s sole and exclusive remedy at law or in equity for an Abatement Event; provided, however, and notwithstanding any term or provision herein to the contrary, if such Abatement Event continues for longer than one hundred eighty
(180) days after Lessee gives Lessor written notice thereof and is the result of a Lessor default under this Lease, then Lessee also shall be entitled to avail itself of all remedies available at law or in equity. 

12. Assignment and Subletting. 

12.1 Lessor’s Consent Required. 

(a) Lessee shall not voluntarily or by operation of law assign, transfer, mortgage or otherwise transfer or encumber (collectively,
“assign” or “assignment”) or sublet all or any part of Lessee’s interest or obligations in this Lease or in the Premises without Lessor’s prior written consent given under and subject to the terms of Paragraph 36, which
Lessor shall not withhold unreasonably. The parties agree, however, that the manner of operation of the Premises and conduct of business thereon by Lessee will have an impact on the quality and reputation of the Industrial Center. Accordingly, the
parties agree that in approving or disapproving of any proposed assignment or subletting of the Premises or the Lease, Lessor shall be entitled to take into consideration, by way of example and not limitation, any or all of the criteria set forth
below and that it shall not be unreasonable for Lessor to withhold its consent if any of the following circumstances exist or may exist: (i) the transferee’s contemplated use of the Premises following the proposed assignment or subletting
is different from the permitted use specified herein; (ii) in Lessor’s reasonable business judgment, the transferee lacks the financial ability to perform its obligations under the sublease or assignment: (iii) intentionally deleted;
(iv) the proposed assignment or subletting would breach any covenant of Lessor in any other lease, financing agreement or other agreement relating to the Industrial Center or otherwise; or (v) the transferee requests an amendment to the
Lease other than the identity of Lessee. No assignment or subletting shall release Lessee from its obligations and liabilities hereunder. Notwithstanding anything to the contrary contained in this Paragraph 12, Lessee may assign this Lease or
sublease the Premises (“Permitted Transfers”), without Lessor’s consent but upon ten (10) days prior notice to Lessor, to any corporation which controls, is controlled by or is under common control with Lessee, or to any
corporation resulting from the merger of or consolidation with Lessee or to any purchaser acquiring substantially all of the assets or stock of Lessee (“Lessee’s Affiliate”), provided that the Net Worth of Lessee, as
hereinafter defined, is not reduced by an amount equal to or greater than twenty percent (20%) of such Net Worth of Lessee as it exists immediately prior to such Permitted Transfer. “Net Worth” of Lessee for purposes of this
Lease shall be the net worth of Lessee (excluding any guarantors) established under generally accepted accounting principles consistently applied. In such case (unless Lessee is the surviving entity following such Permitted Transfer), any
Lessee’s Affiliate shall assume in writing all of Lessee’s obligations under this Lease. 
 (b) Subject to
subparagraph (a) above, a “Change of Control” of Lessee shall constitute an assignment requiring Lessor’s consent. Change of Control shall mean the transfer by sale, assignment, death, incompetency, mortgage, deed of
trust, trust, operation of law, or otherwise, of any shares, voting rights or ownership interest, on a cumulative basis, of fifty-one percent (51%) or more of the voting control of Lessee, unless such change results from the trading of shares
listed on a recognized public stock exchange. Notwithstanding the foregoing, neither the sale, issuance nor transfer of Lessee’s capital stock in connection with an equity financing shall constitute a Change of Control. 

(c) Intentionally deleted. 

(d) An assignment or subletting of Lessee’s interest in this Lease without Lessor’s specific prior written consent shall be a
Default curable after notice per Paragraph 13.1. 
 (e) Lessee’s remedy for any breach of this Paragraph 12.1 by Lessor shall be
limited to compensatory damages and/or injunctive relief. 

  
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 12.2 Terms and Conditions Applicable to Assignment and Subletting. 

(a) Regardless of Lessor’s consent, any assignment or subletting shall not (i) be effective without the express written assumption
by such assignee or sublessee of the obligations of Lessee under this Lease, (ii) release Lessee of any obligations hereunder, nor (iii) alter the primary liability of Lessee for the payment of Base Rent and other sums due Lessor hereunder
or for the performance of any other obligations to be performed by Lessee under this Lease. 
 (b) Lessor may accept any rent or
performance of Lessee’s obligations from any person other than Lessee pending approval or disapproval of an assignment. Neither a delay in the approval or disapproval of such assignment nor the acceptance of any rent for performance shall
constitute a waiver or estoppel of Lessor’s right to exercise its remedies for the Default or Breach by Lessee of any of the terms, covenants or conditions of this Lease. 

(c) The consent of Lessor to any assignment or subletting shall not constitute consent to any subsequent assignment or subletting by Lessee
or to any subsequent or successive assignment or subletting by the assignee or sublessee. However, Lessor may consent to subsequent sublettings and assignments of the sublease or any amendments or modifications thereto without notifying Lessee or
anyone else liable under this Lease or the sublease and without obtaining their consent, and such action shall not relieve such persons from liability under this Lease or the sublease. 

(d) In the event of any Breach of Lessee’s obligation under this Lease, Lessor may proceed directly against Lessee or anyone else
responsible for the performance of the Lessee’s obligations under this Lease, including any sublessee, without first exhausting Lessor’s remedies against any other person or entity responsible therefor to Lessor, or any security held by
Lessor. 
 (e) Should Lessee desire to enter into an assignment or subletting transaction, Lessee shall give notice thereof to Lessor by
requesting in writing Lessor’s consent to such assignment or subletting at least fifteen (15) days before the proposed effective date of any such assignment or subletting and shall provide Lessor with the following: (i) the full
particulars of the proposed assignment or subletting transaction, including its nature, effective date, terms and conditions, and copies of any documents pertaining to such proposed transaction; (ii) a description of the identity, net worth and
previous business experience of the transferee, including, without limitation, copies of transferee’s latest income, balance sheet and change-of-financial-position statements (with accompanying notes and disclosures of all material changes
thereto) in audited form, if available, and certified as accurate by the transferee; and (iii) any further information relevant to the transaction which Lessor shall have requested within ten (10) days after receipt of Lessee’s
request for consent and all information specified above in Subparagraphs (i), (ii) and (iii). 
 Each assignment or subletting to
which Lessor has consented shall be evidenced by an instrument made in such written form as is satisfactory to Lessor and executed by Lessee and transferee. By such instrument, transferee shall assume all the terms, covenants and conditions of this
Lease, which are obligations of Lessee from and after such transfer. Lessee shall remain fully liable to perform its duties under the Lease following the assignment or subletting. Lessee shall, on demand of Lessor, reimburse Lessor for Lessor’s
reasonable costs, including legal fees, incurred in obtaining advice and preparing documentation for each assignment or subletting to which Lessor has consented, not to exceed $2,000.00. 

(f) Any assignee of, or sublessee under, this Lease shall, by reason of accepting such assignment or entering into such sublease, be deemed,
for the benefit of Lessor, to have assumed and agreed to conform and comply with each and every term, covenant, condition and obligation herein to be observed or performed by Lessee during the term of said assignment or sublease, other than such
obligations as are contrary to or inconsistent with provisions of an assignment or sublease to which Lessor has specifically consented in writing. 

(g) Intentionally deleted. 

(h) Intentionally deleted. 

(i) If Lessor consents to an assignment or subletting, as a condition thereto which the parties hereby agree is reasonable, Lessee shall pay
to Lessor any “Transfer Premium,” as that term is defined in this Section, received by Lessee from such assignee or sublessee. “Transfer Premium” shall mean all rent, additional rent or other consideration payable by the
assignee or sublessee in connection with and attributable to the assignment or sublease in excess of the Base Rent under this Lease during the term of the assignment or sublease on a per rentable square foot basis if less than all of the Premises is
transferred, deducting any expenses incurred by Lessee in connection with the assignment or subletting, including without limitation, expenses of marketing, brokerage commissions, improvement costs and reasonable attorneys’ fees, but excluding
loss of rent. “Transfer Premium” shall also include, but not be limited to, key money, bonus money or other cash consideration paid by such assignee or sublessee to Lessee in connection with and attributable to such assignment or sublease.
The determination of the amount of Lessor’s applicable share of the Transfer Premium shall be made on a monthly basis as rent or other consideration is received by Lessee under the assignment or sublease. The provisions of this subparagraph
(i) shall not apply to Permitted Transfers. 

  
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 (j) In the event of a proposed assignment or subletting of more than fifty percent (50%) of
the Premises for all or substantially all of the remainder of the Term (excluding any Permitted Transfer), Lessor shall also have the right, by notice to Lessee, to terminate this Lease in the event of an assignment as to all of the Premises and, in
the event of a sublease of more than fifty percent (50%) of the rentable square feet of the Premises in the aggregate for all or substantially all of the remainder of the Lease Term, as to the subleased portion of the Premises and to require
that all or part, as the case may be, of the Premises be surrendered to Lessor for the balance of the Term (collectively “Recapture the Lease”). Notwithstanding the previous sentence, if, before entering into a proposed assignment or
sublease, Lessee gives written notice to Lessor of Lessee’s intention to sublease or assign. and Lessor does not, within fifteen (15) business days after Lessor’s actual receipt of such written notice and all information requested by
Lessor relating to such proposed assignment or subletting, inform Lessee that Lessor intends to Recapture the Lease, then Lessor may not Recapture the Lease by reason of such proposed assignment or subletting, provided that: (i) if Lessor
consents to the proposed assignment or subletting, Lessee shall complete such assignment or sublease within one hundred eighty (180) days after the end of such fifteen (15) day period, and (ii) nothing contained in this subjection
(j) shall be deemed to waive any of Lessor’s rights to approve or disapprove an assignment or sublease as provided in Section 12.1 of this Lease. 

12.3 Additional Terms and Conditions Applicable to Subletting. The following terms and conditions shall apply to any subletting
by Lessee of all or any part of the Premises and shall be deemed included in all subleases under this Lease whether or not expressly incorporated therein: 

(a) Lessee hereby assigns and transfers to Lessor all of Lessee’s interest in all rentals and income arising from any sublease of all or
a portion of the Premises heretofore or hereafter made by Lessee, and Lessor may collect such rent and income and apply same toward Lessee’s obligations under this Lease; provided, however, that until a Breach shall occur in the performance of
Lessee’s obligations under this Lease, Lessee may, except as otherwise provided in this Lease, receive, collect and enjoy the rents accruing under such sublease. Lessor shall not, by reason of the foregoing provision or any other assignment of
such sublease to Lessor, nor by reason of the collection of the rents from a sublessee, be deemed liable to the sublessee for any failure of Lessee to perform and comply with any of Lessee’s obligations to such sublessee under such Sublease.
Lessee hereby irrevocably authorizes and directs any such sublessee, upon receipt of a written notice from Lessor stating that a Breach exists in the performance of Lessee’s obligations under this Lease, to pay to Lessor the rents and other
charges due and to become due under the sublease. Sublessee shall rely upon any such statement and request from Lessor and shall pay such rents and other charges to Lessor without any obligation or right to inquire as to whether such Breach exists
and notwithstanding any notice from or claim from Lessee to the contrary. Lessee shall have no right or claim against such sublessee, or, until the Breach has been cured, against Lessor, for any such rents and other charges so paid by said sublessee
to Lessor. 
 (b) In the event of a Breach by Lessee in the performance of its obligations under this Lease, Lessor, at its option and
without any obligation to do so, may require any sublessee to attorn to Lessor, in which event Lessor shall undertake the obligations of the sublessor under such sublease from the time of the exercise of said option to the expiration of such
sublease; provided, however, Lessor shall not be liable for any prepaid rents or security deposit paid by such sublessee to such sublessor or for any other prior defaults or breaches of such sublessor under such sublease. 

(c) Any matter or thing requiring the consent of the sublessor under a sublease shall also require the consent of Lessor herein. 

(d) No sublessee under a sublease approved by Lessor shall further assign or sublet all or any part of the Premises without Lessor’s
prior written consent. 
 (e) Lessor shall deliver a copy of any notice of Default or Breach by Lessee to the sublessee, who shall have the
right to cure the Default of Lessee within the grace period, if any, specified in such notice. The sublessee shall have a right of reimbursement and offset from and against Lessee for any such Defaults cured by the sublessee. 

13. Default; Breach; Remedies. 

13.1 Default; Breach. Lessee’s obligations to Lessor hereunder shall include any and all costs or expenses incurred by
Lessor in conjunction with enforcing Lessor’s rights and remedies hereunder, which shall include, but shall not be limited to, any attorneys’ fees or other legal expenses or costs associated therewith, and that Lessor may include the cost
of such services and costs in any notice of Default as rent due and payable to cure said default. A “Default” by Lessee is defined as a failure by Lessee to observe, comply with or perform any of the terms, covenants, conditions or
rules applicable to Lessee under this Lease. A “Breach” by Lessee is defined as the occurrence of any Default, including but not limited those listed below, and, where a grace period for cure after notice is specified herein,
the failure by Lessee to cure such Default prior to the expiration of the applicable grace period, and shall entitle Lessor to pursue the remedies set forth in Paragraphs 13.2 and/or 13.3: 

  
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 (a) The abandonment of the Premises. 

(b) Except as expressly otherwise provided in this Lease, the failure by Lessee to make any payment of Rent, Lessee’s Share of Common
Area Operating Expenses, or any other monetary payment required to be made by Lessee hereunder as and when due, the failure by Lessee to provide Lessor with reasonable evidence of insurance or surety bond required under this Lease, or the failure of
Lessee to fulfill any obligation under this Lease which endangers or threatens life or property, where such failure continues for a period of three (3) days following written notice thereof by or on behalf of Lessor to Lessee. 

(c) Except as expressly otherwise provided in this Lease, the failure by Lessee to provide Lessor with reasonable written evidence (in duly
executed original form, if applicable) of (i) an estoppel certificate per Paragraph 16, or (ii) the subordination or non-subordination of this Lease per Paragraph 30, where any such failure continues for a period of ten (10) days
following written notice by or on behalf of Lessor to Lessee. 
 (d) A Default by Lessee as to the term, covenants, conditions or
provisions of this Lease, or of the Rules and Regulations adopted under Paragraph 39 hereof that are to be observed, complied with or performed by Lessee, other than those described in Subparagraphs 13.1 (a), (b) or (c), above, where such
Default continues for a period of thirty (30) days after written notice thereof by or on behalf of Lessor to Lessee; provided, however, that if the nature of Lessee’s Default is such that more than thirty (30) days are reasonably
required for its cure, then it shall not be deemed to be a Breach of this Lease by Lessee if Lessee commences such cure within said thirty (30) day period and thereafter diligently prosecutes such cure to completion. 

(e) The occurrence of any of the following events: (i) the making by Lessee of any general arrangement or assignment for the benefit of
creditors; (ii) Lessee’s becoming a “debtor” as defined in 11 U.S. Code Section 101 or any successor statute thereto (unless, in the case of a petition filed against Lessee, the same is dismissed within sixty
(60) days); (iii) the appointment of a trustee or receiver to take possession of substantially all of Lessee’s assets located at the Premises or of Lessee’s interest in this Lease, where possession is not restored to Lessee
within thirty (30) days; or (iv) the attachment, execution or other judicial seizure of substantially all of Lessee’s assets located at the Premises or of Lessee’s interest in this Lease, where such seizure is not discharged
within thirty (30) days; provided, however, in the event that any provision of this Subparagraph 13.1 (e) is contrary to any applicable law, such provision shall be of no force or effect, and shall not affect the validity of the remaining
provisions. 
 (f) The discovery by Lessor that any financial statement of Lessee given to Lessor by Lessee was materially false. 

13.2 Remedies. If Lessee Defaults in any affirmative duty or obligation of Lessee under this Lease, within ten (10) days
after written notice to Lessee (or in case of an emergency, without notice), Lessor may at its option (but without obligation to do so), perform such duty or obligation on Lessee’s behalf, including but not limited to the obtaining of
reasonably required bonds, insurance policies, or governmental licenses, permits or approvals. The costs and expenses of any such performance by Lessor shall be due and payable by Lessee to Lessor upon invoice therefor. If any check given to Lessor
by Lessee shall not be honored by the bank upon which it is drawn, Lessor at its own option, may require all future payments to be made under this Lease by Lessee to be made only by cashier’s check. In the event of a Breach of this Lease by
Lessee, with or without further notice or demand, and without limiting Lessor in the exercise of any right or remedy, which Lessor may have by reason of such Breach, Lessor may: 

(a) Terminate Lessee’s right to possession of the Premises by any lawful means, in which case this Lease and the Term hereof shall
terminate and Lessee shall immediately surrender possession of the Premises to Lessor. In such event Lessor shall be entitled to recover from Lessee: (i) the worth at the time of the award of the unpaid rent which had been earned at the time of
termination; (ii) the worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time of award exceeds the amount of such rental loss that the Lessee proves could have been reasonably
avoided; (iii) the worth at the time of award of the amount by which the unpaid rent for the balance of the Term after the time of award exceeds the amount of such rental loss that the Lessee proves could be reasonably avoided; and (iv) any other
amount necessary to compensate Lessor for all the detriment proximately caused by the Lessee’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, including but not
limited to the cost of recovering possession of the Premises, expenses of reletting, including necessary renovation and alteration of the Premises, reasonable attorneys’ fees, and that portion of any leasing commission paid by Lessor in
connection with this Lease applicable to the unexpired Term of this Lease. The worth at the time of award of the amount referred to in provision (iii) of the immediately preceding sentence shall be computed by discounting such amount at the discount
rate of the Federal Reserve Bank of San Francisco or the Federal Reserve Bank District in which the Premises are located at the time of award plus one percent (1%). Efforts by Lessor to mitigate damages caused by Lessee’s Default or Breach of
this Lease shall not waive Lessor’s right to recover damages under this Paragraph 13.2. If termination 

  
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‘of this Lease is obtained through the provisional remedy of unlawful detainer, Lessor shall have the right to recover in such proceeding the unpaid rent and damages as are recoverable
therein, or Lessor may reserve the right to recover all or any part thereof in a separate suit for such rent and/or damages. 
 (b)
Continue the Lease and Lessee’s right to possession in effect (in California under California Civil Code Section 1951.4) after Lessee’s Breach and recover the rent as it becomes due, provided Lessee has the right to sublet or assign,
subject only to reasonable limitations. Lessor and Lessee agree that the limitations on assignment and subletting this Lease are reasonable. Acts of maintenance or preservation, efforts to relet the Premises, or the appointment of a receiver to
protect the Lessor’s interest under this Lease, shall not constitute a termination of the Lessee’s right to possession. 
 (c)
Pursue any other remedy now or hereafter available to Lessor under the laws or judicial decisions of the state wherein the Premises are located. 

(d) The expiration or termination of this Lease and/or the termination of Lessee’s right to possession shall not relieve Lessee from
liability under any indemnity provisions of this Lease as to matters occurring or accruing during the Term hereof or by reason of Lessee’s occupancy of the Premises. 

13.3 Intentionally Deleted. 

13.4 Late Charges. Lessee hereby acknowledges that late payment by Lessee to Lessor of rent and other sums due hereunder will
cause Lessor to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult to ascertain. Such costs include, but are not limited to, processing and accounting charges, and late charges, which may be imposed
upon Lessor by the terms of any ground lease, mortgage or deed of trust covering the Premises. Accordingly, if any installment of rent or other sum due from Lessee shall not be received by Lessor or Lessor’s designee within five (5) days
after written notice that such amount is past-due, then, without any requirement for notice to Lessee, Lessee shall pay to Lessor a late charge equal to five percent (5%) of such overdue amount. The parties hereby agree that such late charge
represents a fair and reasonable estimate of the costs Lessor will incur by reason of late payment by Lessee. Acceptance of such late charge by Lessor shall in no event constitute a waiver of Lessee’s Default or Breach with respect to such
overdue amount, nor prevent Lessor from exercising any of the other rights and remedies granted hereunder. In the event that a late charge is payable hereunder, whether or not collected, for three (3) consecutive installments of Base Rent, then
notwithstanding Paragraph 4.1 or any other provision of this Lease to the contrary, Base Rent shall, at Lessor’s option, become due and payable quarterly in advance. 

13.5 Breach by Lessor. Lessor shall not be deemed in breach of this Lease unless Lessor fails within a reasonable time to
perform an obligation required to be performed by Lessor. For purposes of this Paragraph 13.5, a reasonable time shall in no event be less than thirty (30) days after receipt by Lessor, and by any Lender(s) whose name and address shall have
been furnished to Lessee in writing for such purpose, of written notice specifying wherein such obligation of Lessor has not been performed; provided, however, that if the nature of Lessor’s obligation is such that more than thirty
(30) days after such notice are reasonably required for its performance. then Lessor shall not be in breach of this Lease if performance is commenced within such thirty (30) day period and thereafter diligently pursued to completion.

 14. Condemnation. If the Premises or any portion thereof are permanently taken under the power of eminent domain or sold under
the threat of the exercise of said power (all of which are herein called “condemnation”, this Lease shall terminate as to the part so taken as of the date the condemning authority takes title or possession, whichever first occurs. If more
than ten percent (10%) of the floor area of the Premises, or more than twenty-five percent (25%) of the portion of the Common Areas designated for Lessee’s parking, is taken by condemnation, Lessee may, at Lessee’s option, to be
exercised in writing within ten (10) days after Lessor shall have given Lessee written notice of such taking (or in the absence of such notice, within ten (10) days after the condemning authority shall have taken possession) terminate this
Lease as of the date the condemning authority takes such possession. If Lessee does not terminate this Lease in accordance with the foregoing, this Lease shall remain in full force and effect as to the portion of the Premises remaining, except that
the Base Rent shall be reduced in the same proportion as the rentable floor area of the Premises taken bears to the total rentable floor area of the Premises. No reduction of Base Rent shall occur if the condemnation does not apply to any portion of
the Premises. Any award for the taking of all or any part of the Premises under the power of eminent domain or any payment made under threat of the exercise of such power shall be the property of Lessor, whether such award shall be made as
compensation for diminution of value of the leasehold or for the taking of the fee, or as severance damages; provided, however, that Lessee shall be entitled to any compensation, specifically awarded for Lessee’s relocation expenses and/or loss
of Lessee’s Trade Fixtures. In the event that this Lease is not terminated by reason of such condemnation, Lessor shall to the extent of its net severance damages received, over and above Lessee’s Share of the legal and other expenses
incurred by Lessor in the condemnation matter, repair any damage to the Premises caused by such condemnation authority. 

  
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 15. Brokers. 

15.1 Procuring Cause. The Broker(s) named in Paragraph 1.10 is/are the procuring cause of this Lease. 

15.2 Representations and Warranties. Lessee and Lessor each represent and warrant to the other that it has had no dealings with any
person, firm, broker or finder other than as named in Paragraph 1.10 in connection with the negotiation of this Lease and/or the consummation of the transaction contemplated hereby, and that no broker or other person, firm or entity other than said
named Broker(s) is entitled to any commission or finder’s fee in connection with said transaction. Lessee and Lessor do each hereby agree to indemnify, protect, defend and hold the other harmless from and against liability for compensation or
charges which may be claimed by any such unnamed broker, finder or other similar party by reason of any dealings or actions of the indemnifying Party, including any costs, expenses, and/or attorneys’ fees reasonably incurred with respect
thereto. 
 16. Estoppel Certificate and Financial Statements. 

16.1 Estoppel Certificate. Within ten (10) days after written notice from Lessor, Lessee shall execute and deliver to
Lessor a certificate in the form attached as Exhibit D or such other form reasonably requested by Lessor or Lessor’s lender, purchaser or ground lessor may reasonably request stating such matters reflecting the status of this Lease or the
Premises as Lessor or Lessor’s lender, purchaser or ground lessor may reasonably request. Within ten (10) days after written request by Lessee, for any reasonable business purpose, Lessor shall execute and deliver to Lessee a certificate
reasonably acceptable to Lessor stating such matters reflecting the status of this Lease or the Premises as Lessee may reasonably request. 

16.2 Financial Statement. If Lessor desires to finance, refinance, or sell the Premises or the Building, or any part thereof,
Lessee and all Guarantors shall deliver to any potential lender or purchaser designated by Lessor, within (10) days following a request in writing by Lessor, Lessee’s current financial statements and after the 2012 calendar year,
Lessee’s financial statements for the past three (3) years. All such financial statements shall be received by Lessor and such lender or purchaser in confidence and shall be used only for the purposes herein set forth. 

17. Lessor’s Liability. The term “Lessor” as used herein shall mean the owner or owners at the time in question
of the fee title to the Premises. In the event of a transfer of Lessor’s title or interest in the Premises or in this Lease, Lessor shall deliver to the transferee or assignee (in cash or by credit) any unused Security Deposit held by Lessor at
the time of such transfer or assignment. Upon such transfer or assignment, the written assumption of this Lease by such transferee and delivery of the Security Deposit, as aforesaid, the prior Lessor shall be relieved of all liability with respect
to the obligations and/or covenants under this Lease thereafter to be performed by the Lessor. Subject to the foregoing, the obligations and/or covenants in this Lease to be performed by the Lessor shall be binding only upon the Lessor as
hereinabove defined. In no event shall the obligations of Lessor under this Lease constitute personal obligations of Lessor’s direct or indirect partners, members, managers, directors, officers, shareholders, employees or representatives, and
Lessee hereby expressly waives such personal liability on behalf of itself and all persons claiming by, through or under Lessee. Further, Lessee, for satisfaction of any liability of Lessor under this Lease, may seek recourse only against
Lessor’s interest in the Premises and all rents, issues, profits and proceeds thereof and shall not seek recourse against Lessor’s other assets or against Lessor’s direct or indirect partners, members, managers, directors, officers,
shareholders, employees or representatives or any of their respective personal assets. 
 18. Severability. The invalidity of any
provision of this Lease, as determined by a court of competent jurisdiction, shall in no way affect the validity of any other provision hereof. 

19. Interest on Past-Due Obligations. Any monetary payment due Lessor hereunder, other than late charges, not received by Lessor within
ten (10) days following the date on which it was due, shall bear interest from the date due at the prime rate charged by the largest state chartered bank in the State in which the Premises are located plus four percent (4%) per annum, but
not exceeding the maximum rate allowed by law, in addition to the potential late charge provided for in Paragraph 13.4.  
 20.
Time of Essence. Time is of the essence with respect to the performance of all obligations to be performed or observed by the Parties under this Lease. 

21. Rent Defined. All monetary obligations of Lessee to Lessor under the terms of this Lease are deemed to be rent. 

22. No Prior or Other Agreements. This Lease contains all agreements between the Parties with respect to any matter mentioned herein,
and no other prior or contemporaneous agreement or understanding shall be effective. 
 23. Notices. All notices required or
permitted by this Lease shall be in writing and shall be and deemed duly served or given when actually delivered, if personally delivered (including delivery by Federal Express, Express Mail or other similar overnight or personal courier service
which confirms delivery in writing), or within three (3) business days after deposit in the U.S. Mail, if sent 

  
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by certified mail, postage prepaid, return receipt requested, and shall be deemed sufficiently given if served in a manner specified in this Paragraph 23. If notice is received on a Saturday or a
Sunday or a legal holiday, it shall be deemed received on the next business day. The addresses noted adjacent to a Party’s signature on this Lease shall be that Party’s address for delivery or mailing of notice purposes. Either Party may
by written notice to the other specify a different address for notice purposes, except that upon Lessee’s taking possession of the Premises, the Premises shall constitute Lessee’s address for the purpose of mailing or delivering notices to
Lessee. A copy of all notices required or permitted to be given to Lessor hereunder shall be concurrently transmitted to such party or parties at such addresses as Lessor may from time to time hereafter designate by written notice to Lessee. 

24. Waivers. No waiver by Lessor of the Default or Breach of any term, covenant or condition hereof by Lessee, shall be deemed a waiver
of any other term, covenant or condition hereof, or of any subsequent Default or Breach by Lessee of the same or any other term, covenant or condition hereof. Lessor’s consent to, or approval of, any such act shall not be deemed to render
unnecessary the obtaining of Lessor’s consent to, or approval of, any subsequent or similar act by Lessee, or be construed as the basis of an estoppel to enforce the provision or provisions of this Lease requiring such consent. Regardless of
Lessor’s knowledge of a Default or Breach at the time of accepting rent, the acceptance of rent by lessor shall not be a waiver of any Default or Breach by Lessee of any provision hereof. Any payment given Lessor by Lessee may be accepted by
Lessor on account of moneys or damages due Lessor, notwithstanding any qualifying statements or conditions made by Lessee in connection therewith, which such statements and/or conditions shall be of no force or effect whatsoever unless specifically
agreed to in writing by Lessor at or before the time of deposit of such payment. 
 25. Intentionally Omitted. 

26. No Right To Holdover. Lessee has no right to retain possession of the Premises or any part thereof beyond the expiration or earlier
Termination of this Lease. In the event that Lessee holds over in violation of this Paragraph 26 then the Base Rent payable from and after the time of the expiration or earlier termination of this Lease shall be increased to one hundred fifty
percent (150%) of the Base Rent applicable during the month immediately preceding such expiration or earlier termination. Nothing contained herein shall be construed as consent by Lessor to any holding over by Lessee. 

27. Cumulative Remedies. No remedy or election hereunder shall be deemed exclusive but shall, wherever possible, be cumulative with all
other remedies at law or in equity. 
 28. Covenants and Conditions. All provisions of this Lease to be observed or performed by
Lessee are both covenants and conditions. 
 29. Binding Effect; Choice of Law. This Lease shall be binding upon the Parties, their
personal representatives, successors and assigns and be governed by the laws of the State in which the Premises are located. Lessee expressly agrees that any and all disputes arising out of or in connection with this Lease shall be litigated only in
the Superior Court of the State of California for the county in which the Premises are located (and in no other), and Lessee hereby consents to the jurisdiction of said court. 

30. Subordination; Attornment; Non-Disturbance. 

30.1 Subordination. This Lease and any Option granted hereby shall automatically be subject and subordinate to any ground lease,
mortgage, deed of trust, or other hypothecation or security device or amendment or modification thereto (collectively, “Security Device”), now or hereafter placed by Lessor upon the real property of which the Premises are a part, to
any and all advances made on the security thereof, and to all renewals, modifications, consolidations, replacements and extensions thereof. Lessee agrees that the Lenders holding any such Security Device shall have no duty, liability or obligation
to perform any of the obligations of Lessor under this Lease, but that in the event or Lessor’s default with respect to any such obligation, Lessee will give any Lender whose name and address have been furnished Lessee in writing for such
purpose notice of Lessor’s default pursuant to Paragraph 13.5. If any Lender shall elect to have this Lease and/or any Option granted hereby superior to the lien of its Security Device and shall give written notice thereof to Lessee, this Lease
and such Options shall be deemed prior to such Security Device, notwithstanding the relative dates of the documentation or recordation thereof. 

30.2 Attornment. Subject to the non-disturbance provisions of Paragraph 30.3, Lessee agrees to attom to a Lender or any other
party who acquires ownership of the Premises by reason of a foreclosure of a Security Device, and that in the event of such foreclosure, such new owner shall not: (i) be liable for any act or omission or any prior lessor or with respect to
events occurring prior to acquisition of ownership, (ii) be subject to any offsets or defenses which Lessee might have against any prior lessor, or (iii) be bound by prepayment of more than one month’s rent. 

30.3 Non-Disturbance. With respect to Security Devices entered into for the first time (as opposed to amendments or
modifications to existing Security Devices) by Lessor after the execution of this Lease, Lessee’s subordination of this Lease shall be subject to the receipt of an assurance (a “Nondisturbance Agreement”) from the Lender that
Lessee’s possession and this Lease, including any options to extend the Term hereof, will not be disturbed so long as Lessee is not in Breach hereof and attorns to the record owner of the Premises. 

  
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 30.4 Self-Executing. The agreements contained in this Paragraph 30 shall be
effective without the execution of any further documents; provided, however, that upon written request from Lessor or a Lender in connection with a sale, financing or refinancing of Premises, Lessee and Lessor shall execute such further writings as
may be reasonably required to separately document any such subordination or non-subordination, attornment and/or non-disturbance agreement as is provided for herein, including, without limitation, the form of subordination, non-disturbance and
attornment agreement attached as Exhibit F to this Lease. Within thirty (30) days following the Effective Date, Lessor shall obtain a subordination, non-disturbance and attornment agreement in the form attached as Exhibit F to this
Lease from Lessor’s existing lender. 
 31. Attorneys’ Fees. If any Party brings an action or proceeding to enforce
the terms hereof or declare rights hereunder, the Prevailing Party (as hereafter defined) in any such proceeding, action, or appeal thereon, shall be entitled to reasonable attorneys’ fees. Such fees may be awarded in the same suit or recovered
in a separate suit, whether or not such action or proceeding is pursued to decision or judgment. The term “Prevailing Party” shall include, without limitation, a Party who substantially obtains or defeats the relief sought, as the
case may be, whether by compromise, settlement, judgment, or the abandonment by the other Party of its claim or defense. The attorneys’ fee award shall not be computed in accordance with any court fee schedule, but shall be such as to fully
reimburse all attorneys’ fees reasonably incurred. Lessor shall be entitled to attorneys’ fees, costs and expenses incurred in preparation and service of notices of Default and consultations in connection therewith, whether or not a legal
action is subsequently commenced in connection with such Default or resulting Breach. 
 32. Lessor’s Access; Showing Premises;
Repairs. Lessor and Lessor’s agents shall have the right to enter the Premises at any time, in the case of an emergency, and otherwise at reasonable times upon one (1) business day prior notice for the purpose of showing the same to
prospective purchasers, lenders, or lessees, and making such alterations, repairs, improvements or additions to the Premises or to the Building, as Lessor may reasonably deem necessary. Lessor may at any time place on or about the Premises or
Building any ordinary “For Sale” signs and Lessor may at any time during the last one hundred eighty (180) days of the Term hereof place on or about the Premises any ordinary “For Lease” signs. All such activities of Lessor
shall be without abatement of rent or liability to Lessee. Lessor shall use commercially reasonable efforts to minimize any interference with Lessee’s operations at the Premises and any entry by Lessor and Lessor’s agents shall comply with
Lessee’s reasonable security measures, provided that Lessor has received notice of such security measures. 
 33. Auctions.
Lessee shall not conduct, nor permit to be conducted, either voluntarily or involuntarily, any auction upon the Premises without first having obtained Lessor’s prior written consent. Notwithstanding anything to the contrary in this Lease,
Lessor shall not be obligated to exercise any standard of reasonableness in determining whether to grant such consent. 
 34. Signs.
Lessee shall not place any sign upon the exterior of the Premises or the Building, except that Lessee may, with Lessor’s prior written consent, install (but not on the roof) such signs as are reasonably required to advertise Lessee’s own
business so long as such signs are in a location designated by Lessor and comply with Applicable Requirements and the signage criteria established for the Industrial Center by Lessor. The right granted under this paragraph shall be personal to the
originally named Lessee under this Lease and any Lessee’s Affiliate in connection with a Permitted Transfer. Such signage shall comply with all applicable laws, statutes, regulations, ordinances and restrictions, including but not limited to,
any permit requirements. Lessee shall install and maintain said signage in good condition and repair at its sole cost and expense during the entire Term. The installation of any sign on the Premises by or for Lessee shall be subject to the
provisions of Paragraph 7 (Maintenance, Repairs, Utility Installations, Trade Fixtures and Alterations). Notwithstanding anything to the contrary herein, Lessor shall have no right to install advertising signs on the Building, including the roof.
 
 35. Termination; Merger. Unless specifically stated otherwise in writing by Lessor, the voluntary or other surrender of
this Lease by Lessee, the mutual termination or cancellation hereof, or a termination hereof by Lessor for Breach by Lessee, shall automatically terminate any sublease or lesser estate in the Premises; provided, however, Lessor shall, in the event
of any such surrender, termination or cancellation, have the option to continue any one or all of any existing subtenancies. Lessor’s failure within ten (10) days following any such event to make a written election to the contrary by
written notice to the holder of any such lesser interest, shall constitute Lessor’s election to have such event constitute the termination of such interest. 

36. Consents. Except for Paragraph 33 hereof (Auctions) or as otherwise provided herein, wherever in this Lease the consent of a Party
is required to an act by or for the other Party, such consent shall not be unreasonably withheld or delayed. Lessor’s actual costs and expenses (including but not limited to attorneys’ fees) incurred in the consideration of, or response
to, a request by Lessee for any Lessor consent pertaining to an assignment a subletting shall be paid by Lessee to Lessor upon receipt of an invoice therefor (not to exceed $2,000.00). Lessor’s consent to any act, assignment of this Lease or
subletting of the Premises by Lessee shall not constitute an acknowledgment that no Default or Breach by Lessee of this Lease exists, nor shall such consent be deemed a waiver of any then existing Default or Breach, except as may be otherwise
specifically stated in writing by Lessor at the time of such consent. Lessee acknowledges all conditions to Lessor’s consent authorized by this Lease as being reasonable. The failure to specify herein any particular condition to Lessor’s
consent shall not preclude the impositions by Lessor at the time of consent of such further or other conditions as are then reasonable with reference to the particular matter for which consent is being given. 

  
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 37. Intentionally Deleted. 

38. Quiet Possession. Upon payment by Lessee of the Rent for the Premises and the performance of all of the covenants, conditions and
provisions on Lessee’s part to be observed and performed under this Lease, and unless specifically provided herein, Lessee shall have quiet possession of the Premises for the entire Term hereof subject to all of the provisions of this Lease.

 39. Rules and Regulations. Lessee agrees that it will abide by, and keep and observe all reasonable rules and regulations
(“Rules and Regulations”) which Lessor may make from time to time for the management, safety, care, and cleanliness of the grounds, the parking and unloading of vehicles and the preservation of good order, as well as for the
convenience of other occupants or Lessee of the Building and the Industrial Center and their invitees, provided that Lessor shall enforce such Rules and Regulations in a uniform and nondiscriminatory manner. In no event shall the Rules and
Regulations unreasonably interfere with Lessee’s use of the Premises as permitted under this Lease or Lessee’s parking rights granted under this Lease or materially increase the obligations or decrease the rights of Lessee under this
Lease. The current Rules and Regulations for the Industrial Center are attached hereto as Exhibit E. 
 40. Security Measures.
Lessee hereby acknowledges that the rental payable to Lessor hereunder does not include the cost of guard service or other security measures, and that Lessor shall have no obligation whatsoever to provide same. Lessee assumes all responsibility for
the protection of the Premises, Lessee, its agents and invitees and their property from the acts of third parties and shall install, at Lessee’s sole cost and expense, any and all necessary security devices. 

41. Reservations. Lessor reserves the right, from time to time, to grant, without the consent or joinder of Lessee, such easements,
rights of way, utility raceways, and dedications that Lessor deems necessary, and to cause the recordation of parcel maps and restrictions, so long as such easements, rights of way, utility raceways, dedications, maps and restrictions do not
reasonably interfere with the use of the Premises by Lessee. Lessee agrees to sign any documents reasonably requested by Lessor to effectuate any such easement rights, dedication, map or restrictions. 

42. Performance Under Protest. If at any time a dispute shall arise as to any amount or sum of money to be paid by one Party to the
other under the provisions hereof, the Party against whom the obligation to pay the money is asserted shall have the right to make payment “under protest” and such payment shall not be regarded as a voluntary payment and there shall
survive the right on the part of said Party to institute suit for recovery of such sum. If it shall be adjudged that there was no legal obligation on the part of said Party to pay such sum or any part thereof, said Party shall be entitled to recover
such sum or so much thereof as it was not legally required to pay under the provisions of this Lease. 
 43. Authority. If either
Party hereto is a corporation, trust, or general or limited partnership, such Party represents and warrants that the individual executing this Lease on behalf of such Party is duly authorized to execute and deliver this Lease on its behalf. If
Lessee is a corporation, trust or partnership, Lessee shall, within thirty (30) days after request by Lessor, deliver to Lessor evidence satisfactory to Lessor of such authority. 

44. Conflict. The typewritten or handwritten provisions shall control any conflict between the printed provisions of this Lease and the
typewritten or handwritten provisions. 
 45. Offer. Preparation of this Lease by either Lessor or Lessee or Lessor’s agent or
Lessee’s agent and submission of same to Lessee or Lessor shall not be deemed an offer to lease. This Lease is not intended to be binding until executed and delivered by all Parties hereto. 

46. Amendments. This Lease may be modified only in writing, signed by the parties in interest at the time of the modification.
The Parties shall amend this Lease from time to time to reflect any adjustments that are made to the Base Rent or other rent payable under this Lease. 

47. Multiple Parties. Except as otherwise expressly provided herein, if more than one person or entity is named herein as either Lessor
or Lessee, the obligations of such multiple parties shall be the joint and several responsibility of all persons or entities named herein as such Lessor or Lessee. 

48. Construction. Headings at the beginning of each paragraph and subparagraph are solely for the convenience of the parties and are
not a part of the Lease. Whenever required by the context of this Lease, the singular shall include the plural and the masculine shall include the feminine and vice versa. This Lease shall not be construed as if it had been prepared by one of the
parties, but rather as if both parties had prepared the same and, consequently, any inconsistencies or ambiguities herein shall not be interpreted 

  
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against either party as the drafter of the Lease. Unless otherwise indicated, all references to paragraphs and subparagraphs are to this Lease. All exhibits referred to in this Lease are attached
and incorporated by this reference. Except as specifically provided herein, Lessee hereby agrees that Lessee shall not disclose any of the economic terms of this Lease to any person or entity not a party to this Lease, nor shall Lessee issue any
press releases or make any public statements relating to the terms or provisions of this Lease; provided, however, Lessee may make necessary disclosures to potential lenders, attorneys, accountants and space planning consultants, and/or as may be
required by applicable Laws or court order, so long as such parties agree to keep all of the economic terms of this Lease strictly confidential. The obligation of Lessee set forth in this section shall survive the expiration or any earlier
termination of this Lease. 
 THE PARTIES HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM AND PROVISION CONTAINED HEREIN, AND BY THE EXECUTION OF
THIS LEASE SHOW THEIR INFORMED AND VOLUNTARY CONSENT THERETO. THE PARTIES HEREBY AGREE THAT, AT THE TIME THIS LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE COMMERCIALLY REASONABLE AND EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND LESSEE WITH
RESPECT TO THE PREMISES. 
 IF THIS LEASE HAS BEEN FILLED IN, IT HAS BEEN PREPARED FOR YOUR ATTORNEY’S REVIEW AND APPROVAL. FURTHER, EXPERTS SHOULD BE
CONSULTED TO EVALUATE THE CONDITION OF THE PROPERTY AS TO THE POSSIBLE PRESENCE OF ASBESTOS, UNDERGROUND STORAGE TANKS OR HAZARDOUS SUBSTANCES. THE PARTIES SHALL RELY SOLELY UPON THE ADVICE OF THEIR OWN COUNSEL AS TO THE LEGAL AND TAX CONSEQUENCES
OF THIS LEASE. IF THE SUBJECT PROPERTY IS LOCATED IN A STATE OTHER THAN CALIFORNIA, AN ATTORNEY FROM THE STATE WHERE THE PROPERTY IS LOCATED SHOULD BE CONSULTED. 

The parties hereto have executed this Lease at the place on the dates specified above to their respective signatures. 

 

											
	Executed at San Diego, California	 		 	Executed at San Diego, CA
	on June 30, 2010                        	 		 	on 7/3/10                            
			
	LESSOR	 		 	LESSEE
			
	BRS-TUSTIN SAFEGUARD ASSOCIATED II, LLC	 		 	PFENEX INC.,
	a Delaware limited liability company	 		 	Delaware corporation ill
				
	By:	 	BRS-Peppertree Manager, LLC,	 		 	
		 	a Delaware limited liability company, its manager	 		 	By:	 	 /s/ Bertrand C. Liang

		 		 		 		 	Name:	 	Bertrand C. Liang
		 		 		 		 	Title:	 	CEO
		 	By:	 	 /s/ Marc Brutten
	 		 		 	
		 		 	Marc Brutten	 		 		 	
		 		 	its Manager	 		 	By:	 	  

		 		 		 		 	Name:	 	  

		 		 		 		 	Title:	 	  

				
	Address:	 		 		 	
			
	c/o Westcore Properties, LLC	 		 	Address:
	 4445 Eastgate Mall, Suite 210
	 		 		 	

											
	San Diego, CA 92121	 		 	  

	Telephone: (858) 625-4100	 		 	  

	Facsimile: (858) 678-0060	 		 	  

		 		 		 		 	Telephone:	 	 (    )

		 		 		 		 	Facsimile:	 	 (    )

  
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 EXHIBIT A 

PREMISES 
 THE SITE PLAN SET FORTH
HEREIN IS FOR INFORMATIONAL PURPOSES ONLY AND DOES NOT CONSTITUTE A WARRANTY OR REPRESENTATION CONCERNING THE SIZE OR LAYOUT OF THE PREMISES. 
  

 

  
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 EXHIBIT B 

INDUSTRIAL CENTER 
 THE SITE PLAN
SET FORTH HEREIN IS FOR INFORMATIONAL PURPOSES ONLY AND DOES NOT CONSTITUTE AN EXACT MEASUREMENT OF THE PARCELS OWNED BY LESSOR, NOR DOES IT CONSTITUTE A WARRANTY, REPRESENTATION OR AGREEMENT ON THE PART OF LESSOR THAT THE TENANT MIX OR LAYOUT OF
THE INDUSTRIAL CENTER IS OR WILL REMAIN AS INDICATED HEREON. 
  
 

 

  
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 EXHIBIT C 

LEASEHOLD IMPROVEMENT AGREEMENT 

This Leasehold Improvement Agreement shall set forth the terms and conditions relating to the construction of the leasehold improvements in
the Premises. This Leasehold Improvement Agreement is essentially organized chronologically and addresses the issues of the construction of the Premises, in sequence, as such issues will arise during the actual construction of the Premises. All
references in this Leasehold Improvement Agreement to Articles, Paragraphs or Sections of “this Lease” shall mean the relevant portion of the Multi-Tenant Industrial/Commercial Lease (Net) to which this Leasehold Improvement Agreement
is attached as Exhibit C and of which this Leasehold Improvement Agreement forms a part, and all references in this Leasehold Improvement Agreement to Sections of “this Leasehold Improvement Agreement” shall mean the relevant
portion of Sections 1 through 5 of this Leasehold Improvement Agreement. 
 SECTION 1 

LESSOR’S INITIAL CONSTRUCTION IN THE PREMISES 

1.1 Base, Shell and Core of the Premises as Constructed by Lessor. Lessor or its predecessor-in-interest has constructed, at its
sole cost and expense, the base, shell, and core of the Premises (the “Base, Shell, and Core”). The Base, Shell and Core shall consist of those portions of the Premises which were in existence prior to the construction of the tenant
improvements in the Premises for the prior tenant of the Premises. Lessee shall accept the Base, Shell and Core in their “AS IS” condition, without representation, warranty or any improvements by Lessor except as specifically set forth in
this Lease or this Leasehold Improvement Agreement. 
 1.2 Lessor’s Work. Notwithstanding anything to the contrary
in the Lease or this Leasehold Improvement Agreement, promptly after the Effective Date, Lessor shall commence and thereafter diligently perform to completion prior to the Commencement Date the following (collectively, the “Lessor’s
Work”): (i) replace the eleven (11) existing HVAC units with model year 1986 serving the Premises with new units of equal capacity of a type, quality and brand reasonably approved by Lessee, and (ii) replace the existing
air-compressor serving the Premises with a new compressor of the type, quality, capacity and brand reasonably approved by Lessee. The Lessor’s Work shall be constructed in accordance with the approved plans and all applicable laws, in a good
and workmanlike manner, free of defects and using new materials and equipment of good quality. 
 SECTION 2 

LEASEHOLD IMPROVEMENTS 

2.1 Leasehold Improvement Allowance. Lessee shall be entitled to a one-time tenant improvement allowance (the “Leasehold
Improvement Allowance”) of up to Four Hundred Fifty Six Thousand Six Hundred Sixty and No/100 ($456,660.00) for the costs relating to the initial design and construction of Lessee’s improvements (the “Leasehold
Improvements”). In no event shall Lessor be obligated to make disbursements pursuant to this Leasehold Improvement Agreement in a total amount which exceeds the Leasehold Improvement Allowance. In the event that the actual cost of the
Leasehold Improvements is less than the Leasehold Improvement Allowance, Lessee shall not be entitled to such excess or any credit, deduction or offset against rent or any other amounts due under the terms of the Lease; provided that Lessee shall be
permitted to apply up to Five Dollars ($5.00) per square foot of the Premises of the Leasehold Improvement Allowance towards the cost of data cabling the Premises, telecommunications systems and moving expenses and equipment to be used at the
Premises. All Leasehold Improvements for which the Leasehold Improvement Allowance has been made available shall be deemed Lessor’s property under the terms of the Lease. 

2.2 Disbursement of the Leasehold Improvement Allowance. 

2.2.1 Leasehold Improvement Allowance Items. Except as otherwise set forth in this Leasehold Improvement Agreement, the
Leasehold Improvement Allowance shall be disbursed by Lessor for costs related to the design, permitting and construction of the Leasehold Improvements and for the following items and costs (collectively, the “Leasehold Improvement Allowance
Items”): (i) payment of the fees of the “Architect” and the “Engineers,” as those terms are defined in Section 3.1 of this Leasehold Improvement Agreement; (ii) the cost of any changes in the Base,
Shell and Core when such changes are required by the Construction Drawings; and (iii) except as otherwise provided herein, the cost of any changes to the Construction Drawings or Leasehold Improvements required by all applicable building codes
(the “Code”). Notwithstanding anything to the contrary in the Lease or this Leasehold Improvement Agreement, Lessor shall reimburse Lessee and pay for (and Lessee shall have no responsibility for and the Improvement Allowance shall
not be used for) the following: (a) costs incurred to remove Hazardous Substances from the Premises or the surrounding area; (b) costs recoverable by Lessor upon account of warranties and insurance; (c) costs to bring the Common
Areas, Building systems and any restrooms in the Premises into compliance with Applicable Laws and restrictions, including, without limitation, the Americans with Disabilities Act and environmental laws; and (d) management or other costs
incurred by Lessor; and construction management, profit and overhead charges. Any improvements described in the foregoing sentence shall, at Lessee’s option, be completed by Lessor at Lessor’s sole cost and expense. 

  
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 2.2.2 Disbursements. Lessee shall deliver to Lessor: (i) a request for
payment; (ii) invoices evidencing the labor rendered and materials delivered to the Premises; and (iii) executed conditional mechanics’ lien releases from those “Lessee’s Agents”, as that term is hereinafter defined,
who have performed the Leasehold Improvements for which payment is requested, which releases shall comply with the appropriate provisions, as reasonably determined by Lessor, of applicable laws. Within fifteen (15) business days of receipt of
the foregoing, Lessor shall deliver a check to Lessee made payable to Lessee or, at Lessee’s request, the applicable contractor or supplier, in payment of the lesser of: (A) the amounts so requested by Lessee, as set forth in this
Section 2.2.2, less a ten percent (10%) retention on all amounts due to Lessee’s general contractor (or any subcontractor under Lessee’s general contractor), if such retention has not already been withheld by Lessee from
Lessee’s general contractor in such invoice (the aggregate amount of such retentions to be known as the “Final Retention”), and (B) the balance of any remaining available portion of the Leasehold Improvement Allowance (not
including the Final Retention), provided that Lessor does not reasonably and promptly dispute any request for payment based on non-compliance of any work with the “Approved Working Drawings”, as that term is defined in
Section 3.4 below, or due to any substandard work. Lessor’s payment of such amounts shall not be deemed Lessor’s approval or acceptance of the work furnished or materials supplied as set forth in Lessee’s payment request.
Lessor shall be responsible at its sole cost and expense for all work and improvements to the Common Areas, Building systems and restrooms in the Building required under Applicable Laws as a result of the Leasehold Improvements and. except for the
foregoing, Lessee shall be responsible as its sole cost and expense for all work and improvements to the Premises required under Applicable Laws as a result of the Leasehold Improvements. Lessee’s construction contract shall include a ten
percent (10%) retainage, and, accordingly, Lessor shall not impose any additional retainage under this Leasehold Improvement Agreement. If Lessor breaches its obligation to fund any portion of the Leasehold Improvement Allowance, Lessee shall
have the right to offset such amounts against Rent first coming due under the Lease. Lessor’s obligation to disburse the Leasehold Improvement Allowance shall survive the expiration or termination of the Lease as to expenses properly incurred
prior to such termination and shall be binding on any Lender following any foreclosure or appointment of a receiver. 
 2.2.3
Requests for Payment; Final Retention. Lessee agrees that the Leasehold Improvement Allowance shall be disbursed pursuant to a request for payment made not more often than one time per month. Subject to the provisions of this Leasehold
Improvement Agreement, a check for the Final Retention payable to Lessee shall be delivered by Lessor to Lessee following substantial completion of the Leasehold Improvements, as such term is defined in Lessee’s construction contract, provided
that (i) Lessee delivers to Lessor properly executed unconditional mechanics’ lien releases in compliance with applicable laws; (ii) Lessee has satisfied its obligations under Section 4.5 below, and (iii) Lessor has
determined that no substandard work exists which adversely affects the mechanical, electrical, plumbing, heating, ventilating and air conditioning, life safety or other systems of the Building, the curtain wall of the Building, or the structure of
the Building. Notwithstanding the foregoing, Lessee shall deliver final lien releases in compliance with applicable laws for all Leasehold Improvements promptly upon completion of the Leasehold Improvements. 

2.2.4 Standard Leasehold Improvement Package. Lessor has established specifications (the “Specifications”) for
the Building standard components to be used in the construction of the Leasehold Improvements in the Premises (collectively, the “Standard Improvement Package”), which Specifications shall be supplied to Lessee by Lessor. The
quality of Leasehold Improvements shall be equal to or of greater quality than the quality of the Specifications, provided that Lessor may, at Lessor’s option, require the Leasehold Improvements to comply with certain Specifications.

 SECTION 3 

CONSTRUCTION DRAWINGS 

3.1 Selection of Architect/Construction Drawings. Attached hereto as Schedule 1 to this Leasehold Improvement Agreement is
a preliminary scope of work for the Leasehold Improvements, which has been approved by Lessor (the “Approved Scope of Work”). Lessee shall retain an architect/space planner, subject to Lessor’s prior approval, which approval
shall not be unreasonably withheld or delayed (the “Architect”) to prepare the “Construction Drawings,” as that term is defined in this Section 3.1. Lessor hereby approves Miller Design as the Architect. Lessee
shall retain the engineering consultants designated by Lessor (the “Engineers”) to prepare all plans and engineering working drawings relating to the structural, mechanical, electrical, plumbing, HVAC, lifesafety, and sprinkler work
of the Leasehold Improvements. The plans and drawings to be prepared by Architect and the Engineers hereunder shall be known collectively as the “Construction Drawings.” All Construction Drawings shall comply with the drawing format
and specifications as reasonably determined by Lessor, and shall be subject to Lessor’s and Lessee’s approval. Lessee and Architect shall verify, in the field, the dimensions and conditions as shown on the relevant portions of the base
Building plans, and Lessee and Architect shall be solely responsible for the same, and Lessor shall have no responsibility in connection therewith. Lessor’s review of the Construction Drawings as set forth in this Section 3, shall
be for its sole purpose and shall not imply Lessor’s review of the same, or obligate Lessor to review the same, for quality, design, Code compliance or other like matters. Accordingly, notwithstanding that any Construction Drawings are prepared
or reviewed by Lessor or its space planner, architect, engineers and consultants, and notwithstanding any advice or assistance which may be rendered to Lessee by Lessor or  

  
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Lessor’s space planner, architect, engineers, and consultants, Lessor shall have no liability whatsoever in connection therewith and shall not be responsible for any omissions or errors
contained in the Construction Drawings, and Lessee’s waiver and indemnity set forth in this Lease shall specifically apply to the Construction Drawings. Lessor will not disapprove any element of the Construction Drawings or final Working
Drawings that is consistent with or represents a logical evolution from the Approved Scope of Work. Lessor and Lessee shall promptly cooperate to resolve any objections to the drawings and specifications for the Leasehold Improvements. 

3.2 Final Space Plan. Lessee shall supply Lessor with four (4) copies signed by Lessee of its final space plan for the
Leasehold Improvements before any architectural working drawings have been commenced. The final space plan (the “Final Space Plan”) shall include a layout and designation of all offices, rooms and other partitioning, their intended
use, and equipment to be contained therein. Lessor may request clarification or more specific drawings for special use items not included in the Final Space Plan. Lessor shall advise Lessee within five (5) business days after Lessor’s
receipt of the Final Space Plan for the Premises if the same is unsatisfactory or incomplete in any respect. If Lessee is so advised, Lessee shall promptly cause the Final Space Plan to be revised to correct any deficiencies or other matters Lessor
may reasonably require. 
 3.3 Final Working Drawings. Upon the approval of the Final Space Plan by Lessor, Lessee
shall promptly cause the Architect and the Engineers to complete the architectural and engineering drawings for the Leasehold Improvements, and the final architectural working drawings in a form which is complete to allow subcontractors to bid on
the work and to obtain all applicable permits (collectively, the “Final Working Drawings”) and shall submit the same to Lessor for Lessor’s approval. Lessee shall supply Lessor with four (4) copies signed by Lessee of such
Final Working Drawings. Lessor shall advise Lessee within five (5) business days after Lessor’s receipt of the Final Working Drawings if the same is unsatisfactory or incomplete in any respect. If Lessee is so advised, Lessee and Lessor
shall meet and cooperate to agree upon the revisions to the Final Working Drawings in accordance with such review and any disapproval of Lessor in connection therewith. Lessor may not object to any items previously approved in the Final Space Plan
unless additional information is provided in the Final Working Drawings which reasonably justifies such disapproval. Lessor and Lessee shall promptly cooperate to resolve any objections to the drawings and specifications for the Leasehold
Improvements. 
 3.4 Permits. Promptly after approval by Lessor of the Final Working Drawings (the
“Approved Working Drawings”), Lessee shall submit the Approved Working Drawings to the appropriate municipal authorities for all applicable building permits necessary to allow “Contractor,” as that term is defined in
Section 4.1 below, to commence and fully complete the construction of the Leasehold Improvements (the “Permits”), and, in connection therewith, Lessee shall coordinate with Lessor in order to allow Lessor, at its option,
to take part in all phases of the permitting process and shall supply Lessor, as soon as possible, with all plan check numbers and dates of submittal and obtain the Permits in a timely manner. Notwithstanding anything to the contrary set forth in
this Section 3.4, Lessee hereby agrees that neither Lessor nor Lessor’s consultants shall be responsible for obtaining any building permit or certificate of occupancy for the Premises and that the obtaining of the same shall be
Lessee’s responsibility; provided however that Lessor shall, in any event, cooperate with Lessee in executing permit applications and performing other ministerial acts reasonably necessary to enable Lessee to obtain any such permit or
certificate of occupancy. No changes, modifications or alterations in the Approved Working Drawings may be made without the prior written consent of Lessor. 

SECTION 4 

CONSTRUCTION OF THE LEASEHOLD IMPROVEMENTS 

4.1 Contractor. A general contractor shall be retained by Lessee to construct the Leasehold Improvements. Such general
contractor (“Contractor”) shall be approved in writing by Lessor, such approval not to be unreasonably withheld or delayed. Promptly after approval by Lessor of the Contractor, Lessee shall cause the Contractor to prepare a
construction schedule and Lessee shall submit the same to Lessor for Lessor’s approval. 
 4.2 Competitive
Bidding. The Contractor shall be selected by Lessee pursuant to a competitive bidding process. Lessee shall select two (2) qualified, licensed and reputable general contractors to participate in the process and Lessor shall have the
right to approve such contractors, which approval shall not be unreasonably withheld or delayed. 
 4.3 Intentionally
Deleted. 
 4.4 Construction of Leasehold Improvements. 

4.4.1 Lessee’s Agents. 

4.4.1.1 Lessor’s General Conditions for Lessee’s Agents and Leasehold Improvement Work. The Leasehold Improvements
shall be constructed substantially in accordance with the Approved Working Drawings. Lessee may reduce or modify the scope of the Leasehold Improvements with Lessor’s consent as required herein. 

  
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 4.4.1.2 Indemnity. Lessee’s indemnity of Lessor as set forth in this Lease
shall also apply with respect to any and all costs, losses, damages, injuries and liabilities related in any way to any act or omission of Lessee or Lessee’s Agents, or anyone directly or indirectly employed by any of them, or in connection
with Lessee’s non-payment of any amount arising out of the Leasehold Improvements and/or any disapproval of all or any portion of any request for payment. Such indemnity by Lessee, as set forth in this Lease, shall also apply with respect to
any cost of the Leasehold Improvements in excess of the Leasehold Improvement Allowance. 
 4.4.1.3 Requirements of
Contractor. The Contractor shall guarantee to Lessee and for the benefit of Lessor that the Leasehold Improvements shall be free from any defects in workmanship and materials for a period of not less than one (1) year from the date of
completion thereof. The Contractor shall be responsible for the replacement or repair, without additional charge, of all work done or furnished in accordance with its contract and any of its subcontracts that shall become defective within one
(1) year after the completion of the work. The correction of such work shall include, without additional charge, all additional expenses and damages incurred in connection with such removal or replacement of all or any part of the Leasehold
Improvements, and/or the Premises that may be damaged or disturbed thereby. All such warranties or guarantees as to materials or workmanship of or with respect to the Leasehold Improvements shall be contained in the Contract shall be written such
that such guarantees or warranties shall inure to the benefit of both Lessor and Lessee, as their respective interests may appear, and can be directly enforced by either. Lessee covenants to give to Lessor any assignment or other assurances which
may be necessary to effect such right of direct enforcement. 
 4.4.1.4 Insurance Requirements. 

4.4.1.4.1 General Coverages. The Contractor shall carry worker’s compensation insurance covering all of their respective
employees, and shall also carry public liability insurance, including property damage, all with limits, in form and with companies as are required by be carried by Lessee as set forth in this Lease. The Contractor shall submit to Lessor a
Certificate of Insurance naming Lessor as additional insured. 
 4.4.1.4.2 Special Coverages. Lessee shall carry
“Builder’s All Risk” insurance in an amount to be approved by Lessor covering the construction of the Leasehold Improvements, it being understood and agreed that the Leasehold Improvements shall be insured by Lessee pursuant to this
Lease immediately upon completion thereof. All of Lessee’s Agents shall carry excess liability and Products and Completed Operation Coverage insurance, in amounts, in form and with companies as are required to be carried by Lessee as set forth
in this Lease. 
 4.4.1.4.3 General Terms. Certificates for all insurance carried pursuant to this
Section 4.4.1.4 shall be delivered to Lessor before the commencement of construction of the Leasehold Improvements and before the Contractor’s equipment is moved onto the site. All such policies of insurance must contain a provision
that the company writing said policy will give Lessor thirty (30) days prior written notice of any cancellation or lapse of the effective date or any reduction in the amounts of such insurance. In the event that the Leasehold Improvements are
damaged by any cause during the course of the construction thereof, Lessee shall immediately repair the same at Lessee’s sole cost and expense. The Contractor shall maintain all of the foregoing insurance coverage in force until the Leasehold
Improvements are fully completed, except for any Products and Completed Operation Coverage insurance required by Lessor, which is to be maintained for three (3) years following completion of the work and acceptance by Lessee. All policies
carried under this Section 4.4.1.4 shall insure Lessor and Lessee, as their interests may appear as well as Contractor and Lessee’s Agents. All insurance, except Worker’s Compensation, maintained by Lessee’s Agents shall
preclude subrogation claims by the insurer against anyone insured thereunder. Such insurance shall provide that it is primary insurance as respects the owner and that any other insurance maintained by owner is excess and noncontributing with the
insurance required hereunder. The requirements for the foregoing insurance shall not derogate from the provisions for indemnification of Lessor by Lessee under Section 4.4.1.2 of this Leasehold Improvement Agreement. 

4.4.2 Governmental Compliance. The Leasehold Improvements shall comply in all respects with the following: (i) state,
federal, city or quasi-governmental laws, codes, ordinances and regulations, as each may apply according to the rulings of the controlling public official, agent or other person; (ii) applicable standards of the American Insurance Association
(formerly, the National Board of Fire Underwriters) and the National Electrical Code; and (iii) building material manufacturer’s specifications. 

4.4.3 Inspection by Lessor. Lessor shall have the right to inspect the Leasehold Improvements at all times during construction,
provided however, that Lessor’s failure to inspect the Leasehold Improvements shall in no event constitute a waiver of any of Lessor’s rights hereunder nor shall Lessor’s inspection of the Leasehold Improvements constitute
Lessor’s approval of the same. Should Lessor disapprove any portion of the Leasehold Improvements, Lessor shall notify Lessee in writing of such disapproval and shall specify the items disapproved. Any defects or deviations in, and/or
disapproval by Lessor of, the Leasehold Improvements shall be rectified by Lessee at no expense to Lessor, provided however, that in the event Lessor determines that a defect or deviation exists or disapproves of any matter in connection with any
portion of the Leasehold Improvements and such defect, deviation or matter might adversely affect the mechanical, electrical, plumbing, heating, ventilating and air conditioning or life-safety systems of the Premises or the Building if Lessee shall
fail to promptly correct the same, Lessor may take such action as Lessor deems  

  
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necessary, at Lessee’s expense and without incurring any liability on Lessor’s part, to correct any such defect, deviation and/or matter, including, without limitation, causing the
cessation of performance of the construction of the Leasehold Improvements until such time as the defect, deviation and/or matter is corrected to Lessor’s satisfaction. 

4.5 Notice of Completion; Copy of Record Set of Plans. Within ten (10) days after completion of construction of the
Leasehold Improvements, Lessee shall cause a Notice of Completion to be recorded in the office of the Recorder of the county in which the Building is located in accordance with applicable laws, and shall furnish a copy thereof to Lessor upon such
recordation. If Lessee fails to do so within two (2) days after notice from Lessor, Lessor may execute and file the same on behalf of Lessee as Lessee’s agent for such purpose, at Lessee’s sole cost and expense. At the conclusion of
construction, (i) Lessee shall cause the Architect and Contractor (A) to update the Approved Working Drawings as necessary to reflect all changes made to the Approved Working Drawings during the course of construction, (B) to certify
to the best of their knowledge that the “record-set” of as-built drawings are true and correct, which certification shall survive the expiration or termination of this Lease, and (C) to deliver to Lessor two (2) sets of copies of
such record set of drawings within ninety (90) days following issuance of a certificate of occupancy for the Premises, (ii) Lessee shall deliver to Lessor a copy of all warranties, guaranties, and operating manuals and information relating
to the improvements, equipment, and systems in the Premises, and (iii) Lessee shall deliver to Lessor the original signed permit card, indicating final approval by all applicable departments. 

SECTION 5 

MISCELLANEOUS 

5.1 Lessee’s Representative. Lessee has designated Hank Talbot as its sole representative with respect to the matters set
forth in this Leasehold Improvement Agreement, who, until further notice to Lessor, shall have full authority and responsibility to act on behalf of the Lessee as required in this Leasehold Improvement Agreement. 

5.2 Lessor’s Representative. Prior to the commencement of construction of the Leasehold Improvements, Lessor shall
designate a representative with respect to the matters set forth in this Leasehold Improvement Agreement, who, until further notice to Lessee, shall have full authority and responsibility to act on behalf of the Lessor as required in this Leasehold
Improvement Agreement. 
 5.3 Time of the Essence in This Leasehold Improvement Agreement. Time is of the essence under
this Leasehold Improvement Agreement. Unless otherwise indicated, all references herein to a “number of days” shall mean and refer to calendar days. In all instances where Lessor is required to approve or deliver an item, if no written
notice of approval is given or the item is not delivered within the stated time period or, if no time period is stated, within seven (7) business days, at Lessee’s sole option, at the end of such period the item shall automatically be
deemed approved or delivered by Lessor and the next succeeding time period shall commence. 
 5.4 Lessee’s Lease
Default. Notwithstanding any provision to the contrary contained in this Lease, if a Breach as described in the Lease, or a default beyond any applicable notice and cure period by Lessee under this Leasehold Improvement Agreement, has
occurred and is continuing at any time on or before the substantial completion of the Leasehold Improvements, then in addition to all other rights and remedies granted to Lessor pursuant to the Lease, Lessor shall have the right to withhold payment
of all or any portion of the Leasehold Improvement Allowance until such time as such default is cured pursuant to the terms of the Lease. 

  
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 SCHEDULE 1 TO LEASEHOLD IMPROVEMENT AGREEMENT 

APPROVED SCOPE OF WORK 
  

 
 Pfenex 
 TI budget -
10790 Roselle 
 29-Apr-10 
  

																	
	 23,833

TI allowance
	  	RSF
??	 	 	Current Budget
??	 	  	Approved
Budget	 	  	Current
Cost/RSF	 
	 Total Available allowance
	  				 	$	0	  	  				  	$	0.00	  
	 Construction Budget (from page two)
	  				 	$	471,576	  	  				  	$	20.65	  
	 Architectural Fees – Estimate
	  	$	22,833.00	  	 				  				  			
	 Electrical and HVAC Engineering Fees – Estimate
	  	$	18,266.40	  	 				  				  			
	 Structural engineering – Estimate
	  	$	0.00	  	 				  				  			
	 Arch / eng reimbursable – Estimate
	  	$	5,000.00	  	 				  				  			
	 Plan Check and Permit Fees – budget
	  				 	$	17,125	  	  				  	$	0.75	  
	 Signage
	  				 	$	0	  	  				  	$	0.00	  
	 Phone Data Cabling
	  				 	$	25,000	  	  				  	$	1.09	  
	 Moving Expenses
	  				 	$	22,833	  	  				  	$	1.00	  
	 IH Project Management Fees
	  				 	$	22,392	  	  				  	$	0.98	  
	 Project Contingency
	  				 	$	26,740	  	  				  	$	1.17	  
		  				 	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Subtotal Construction Soft and Hard Costs
	  				 	$	631,765	  	  	$	0	  	  	$	27.67	  
		  				 	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Total TI Overage for above items
	  				 	$	631,765	  	  	$	0	  	  	$	27.67	  
	 ADDITIONAL FF&E ITEMS
	  				 				  				  			
	 Furniture
	  				 	$	0	  	  				  	$	0.00	  
	 Misc
	  				 	$	17.500	  	  				  	$	0.77	  
	 Security system / restore card readers (allowance)
	  	$	7,500	  	 				  				  			
	 Move phone system and server room (allowance)
	  	$	10,000	  	 				  				  			
		  				 				  				  	$	0.00	  
	 Contingency:
	  	 	5.0	% 	 	$	875	  	  				  	$	0.04	  
		  				 	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Total Additional FF&E Items
	  				 	$	18,375	  	  	$	0	  	  	$	0.80	  
		  				 	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Grand Total Project Cost (total TI costs plus FF&E costs)
	  				 	$	650,140	  	  	$	0	  	  	$	28.47	  
		  				 	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Grand Total Out of Pocket Expense
	  				 	$	650,140	  	  	$	0	  	  	$	28.47	  

  
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 EXHIBIT D 

FORM OF ESTOPPEL CERTIFICATE 

State Farm Bank, F.S.B. 
 One State Farm Plaza 

Bloomington, Illinois 61710-0001 
 Corporate Law —
Investments 
 Attn: (Name of Attorney) 
 Re: 

 

			
	Name of Lessor (as of the date hereof):	  	
	Name of Lessee:	  	
	Name of Lease Guarantor (if any):	  	
	Date of Lease:	  	
	Title and Date(s) of Amendments and Modifications to Lease (if any):	  	
	Address of Premises (including suite number,
if any) (the “Premises”):	  	
	Square Footage of Premises:	  	

 Collectively, the foregoing instrument is hereinafter referred to as the “Lease”. 

Dear Sir or Madam: 
 Lessee is the lessee under
that certain Lease described above and provides this Estoppel Certificate to State Farm Bank, F.S.B. (“State Farm”) as conclusive evidence of the matters set forth herein concerning the Lease and the Premises. 

As of the date hereof, the undersigned hereby certifies the following: 

 

	 	1.	The Lease supersedes, in all respects, all prior written or oral agreements between Lessor and Lessee with respect to the Premises and there are no agreements, understandings, warranties or representations between
Lessor and Lessee with respect to the Lease or the Premises, except as expressly set forth in the Lease. 

  

	 	2.	As of the date hereof, the Lease has not been amended, modified, supplemented or superseded, except pursuant to the amendments or modifications referenced above. 

 

	 	3.	The Lease remains in full force and effect and there are no known existing defaults by Lessee under the Lease. 

  

	 	4.	To Lessee’s current, actual knowledge, the improvements and space required by the Lease to be delivered to Lessee have been satisfactorily completed and delivered by Lessor and have been accepted by the Lessee
except as follows (if blank, none): 

  

	 	5.	The Premises are currently occupied and open for the use by Lessee and its customers, employees and invitees. 

  

	 	6.	Lessee’s interest in the Lease and the Premises demised therein, or any part thereof, has not been sublet, transferred or assigned except as follows (if blank, none):
             

  

                       
                                         
                                         
                                         
        
  
  

                       
                                         
                                         
                                         
                                         
           
  
  

	 	7.	All duties of an inducement nature required of the Lessor under the Lease have been fulfilled by Lessor and Lessee is fully obligated to pay rent and all other charges coming due under the Lease except as follows (if
blank, none):          

  

                       
                                         
                                         
                                         
        
  
  

                       
                                         
                                         
                                         
                                         
           
  

  
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	 	8.	The Commencement Date of the Lease was                     ,
         and the Expiration Date of the Lease is                     ,
20    . 

  

	 	9.	The last monthly payment of rent in the amount of $             was made by Lessee on
                    , 20    . No monthly rental has been prepaid nor has Lessee been given any free rent, partial
rent, rebates, rent rebates or concessions, except as provided in the Lease. Lessee has no current, actual knowledge of any claims, defenses or offsets against any rents payable under the Lease. 

 

	 	10.	A security deposit in the amount of $             has been deposited with Lessor. Lessee agrees to look solely to the Lessor for return of the security
deposit unless the Lessor has deposited the security deposit with State Farm. 

  

	 	11.	To Lessee’s current, actual knowledge, Lessor has fully performed all of its obligations under the Lease and there are no known circumstances existing under which Lessor may be deemed in default merely upon the
service of notice or passage of time, or both, except as follows (if blank, none):              

                       
                                         
                                         
                                         
        
  

                       
                                         
                                         
                                         
                                         
           
  
  

	 	12.	Lessor has not given its consent to Lessee to take any action which, pursuant to the Lease, requires Lessor’s consent except as follows (if blank, none):
             

                       
                                         
                                         
                                         
        
  

                       
                                         
                                         
                                         
                                         
           
  

 

                       
                                         
                                         
                                         
                            

 
  

	 	13.	Lessee has not received any notice of a prior sale, transfer, assignment, pledge or other hypothecation of the Premises, the Lease or of the rents provided for therein. 

 

	 	14.	Lessee has not filed, and is not currently the subject of any filing, voluntary or involuntary, for bankruptcy or reorganization under any applicable bankruptcy or creditors rights laws. 

 

	 	15.	Lessee is a                      duly organized, validly existing and in good standing under the law of
                    . 

In issuing this Estoppel Certificate, Lessee understands that State Farm will rely thereon in funding a $
             mortgage loan to Lessor secured by certain real estate which includes the Premises. Lessee acknowledges that State Farm may rely upon a facsimile of this Estoppel
Certificate signed by Lessee with the same effect as if State Farm had received an Estoppel Certificate bearing Lessee’s original signature. This Estoppel Certificate shall not amend or modify the Lease. 

 

			
	 [NAME OF LESSEE]

		
	 By:
	 	  

	 Name:
	 	  

	 Title:
	 	  

	 Date:
	 	  

  
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 EXHIBIT E 

RULES AND REGULATIONS 

1. No sign, placard, picture, advertisement, name or notice shall be inscribed, displayed or affixed on or to any part of the outside of the
Industrial Center, the Premises or the surrounding area without the written consent of the Lessor being first obtained. If Lessor gives such consent. Lessor may regulate the manner of display of the sign, placard, picture, advertisement, name or
notice. Lessor shall have the right to remove any sign, placard, picture, advertisement, name or notice which has not been approved by Lessor or is being displayed in a non-approved manner without notice to and at the expense of the Lessee. All
approved signs or lettering on doors shall be printed, painted, affixed of inscribed at the expense of Lessee by a person approved by Lessor. Lessor shall not place anything or allow anything to be placed near window, door, partition or wall, which
may appear unsightly from outside of the Premises. 
 2. The directory of the Industrial Center (if any) will be provided exclusively for
the display of the name and location of the lessees only, and Lessor reserves the right to exclude any other names therefrom. 
 3. The
sidewalks, halls, passages, exits and entrances shall not be obstructed by any of the lessees or used by them for any purpose other than for ingress to and egress from their respective Premises. The halls, passages, exits, entrances and roof are not
for the use of the general public and the Lessor shall in all cases retain the right to control thereof and prevent access thereto by all persons whose presence in the judgment of the Lessor shall be prejudicial to the safety, character, reputation
and interests of the Industrial Center or its lessees; provided, however, that nothing herein contained shall be construed to prevent access by persons with whom the Lessee normally deals in the ordinary course of Lessee’s business unless such
persons are engaged in illegal activities. No lessee and no employees or invitees of any lessee shall go upon the roof of the Industrial Center. 

4. Lessee shall not alter any lock or install any new additional locks or bolts on any exterior door of the Premises without the written
consent of Lessor. Lessee may install an electronic alarm system. 
 5. The toilet rooms, urinals, wash bowls and other apparatus shall not
be used for any purpose other than that for which they were constructed and no foreign substance of any kind whatsoever shall be thrown therein. The expense of any breakage, stoppage or damage resulting from a violation of this rule shall be borne
by the Lessee who, or whose employees or invitees, shall have caused it. 
 6. Lessee shall not overload the floor of the Premises and shall
not deface the Premises. 
 7. Except as contemplated by the Lease, Lessee shall not use, keep or permit to be used or kept any noxious gas
or substance in the Premise, or permit or suffer the Premises to be occupied or used in a manner offensive or objectionable to the Lessor or other occupants of the Industrial Center by reason of odors, or interfere in any way with other lessees or
those having business in the Industrial Center. Neither animals nor birds shall be brought in or kept in or about the Premises of the Industrial Center. No lessee shall interfere with occupants of this or neighboring Industrial Centers or Premises,
or with those having business with such occupants, by the use of any musical instruments, radio, phonograph, unusual noise, or in any other way. No lessee shall throw anything out of doors. No cooking shall be done or permitted by Lessee in the
Premises beyond the use of a microwave oven or other small appliances. 
 8. No Lessee shall occupy or permit any portion of its Premises to
be occupied for the manufacture, sale, or use of liquor or narcotics in any form, or as a medical office, or as a barbershop or manicure shop, except without prior written consent of Lessor. The Premises shall not be used for lodging or sleeping or
for illegal purposes. 
 9. No boring or cutting for or stringing of wires will be allowed without the consent of Lessor. 

10. Lessee upon termination of the tenancy, shall deliver to the Lessor the keys to the Premises, offices, rooms, and toilet rooms which shall
have been furnished and shall pay the Lessor the cost of replacing any lost key or of changing the lock or locks opened by such lost key if Lessor deems it necessary to make such change. 

11. No lessee shall lay linoleum, tile, carpet or other similar floor coverings so that the same shall be affixed to the floor of the Premises
in any manner except as approved by the Lessor. The expense of repairing any damage resulting from a violation of this rule or removal of any floor covering shall be borne by the lessee by whom, or by whose contractors, employees or invitees, the
floor covering shall have been laid. 

  
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 12. In case of invasion, mob riot, public excitement, or other commotion, the Lessor reserves the
right to prevent access to the Industrial Center during the continuance of the same, by closing the doors or otherwise, for the safety of the lessees and protection of the Industrial Center and property located therein. Anything to the foregoing
notwithstanding, Lessor shall have no duty to provide security protection for the Industrial Center at any time or to monitor access thereto. 

13. Lessee shall see that the doors of the Premises are closed and securely locked before leaving the Premises and that all water faucets,
water apparatus and electricity are entirely shut off before Lessee or Lessee’s employee’s leave the Premises. Lessee shall be responsible for any damage to the Industrial Center or other lessees’ premises caused by a failure to
comply with this rule. 
 14. Lessor reserves the right to exclude or expel from the Industrial Center any person who, in the judgment of
Lessor, is intoxicated or under the influence of liquor or drugs, or who shall in any manner do any act in violation of any of the rules and regulations of the Industrial Center. 

15. Any requests of Lessee will be considered only upon application at the Office of Lessor. Employees of Lessor shall not be requested to
perform any work or do anything outside of their regular duties unless under special instructions from the Lessor.16. Lessor shall have the right, exercisable with reasonable notice and without liability to Lessee, to change the name and the street
address of the Industrial Center of which the Premises are a part, where such change is required by any government agency. 
 17. Lessee
agrees that it shall comply with all fire regulations that may be issued from time to time by the San Diego Fire Department, and Lessee also shall provide Lessor with the name of a designated responsible employee to represent Lessee in all matters
pertaining to fire regulations. 
 18. Lessor reserves the right by written notice to Lessee, to rescind, alter or waive any rule or
regulation at any time prescribed for the Industrial Center when, in Lessor’s judgment, it is necessary, desirable or proper for the best interest of the Industrial Center or its Lessees. 

19. Lessee shall not disturb, solicit, or canvas any occupant of the Industrial Center and shall cooperate to prevent same. 

20. Without the written consent of Lessor, Lessee shall not use the name of the Industrial Center in connection with or in promotion or
advertising the business of Lessee except as Lessee’s address. 
 21. Lessee shall be entitled to use parking spaces during working
hours. Lessee shall not park in driveways or loading areas, or reserved parking spaces of other lessees. Lessor or its agents shall have the right to cause to be removed any car of Lessee, its employees or agents, that may be parked in unauthorized
areas, and Lessee agrees to save and hold harmless Lessor, its agents and employees from any and all claims, losses, damages and demands asserted or arising in respect to or in connection with the removal of any such vehicle and for all expense
incurred by Lessor in connection with such removal. Lessee will from time to time, upon request of Lessor, supply Lessor with a list of license plate numbers or vehicles owned or operated by its employees and agent. 

  
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 EXHIBIT F 

FORM OF 

SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT 
  

	
	This instrument was prepared by and upon recordation should be returned to:
	  

	  

	  

	  

 SUBORDINATION, NON-DISTURBANCE & ATTORNMENT AGREEMENT 

THIS SUBORDINATION, NON-DISTURBANCE & ATTORNMENT AGREEMENT (this “Agreement”) is made and entered into this
         day of                     , 20    , by and among
                    , a
                     (“Lessor”), whose mailing address is
                                         
               , a                         
(“Lessee”), whose mailing address is                     , and STATE FARM BANK, F.S.B., a federal savings bank (“State
Farm”), whose mailing address is One State Farm Plaza, Bloomington, Illinois 61710-0001. 
 RECITALS 

A. Lessor and Lessee have heretofore entered into a certain lease (the “Lease”) dated
                    ,          with respect to and governing the terms of Lessee’s use and
occupancy of all or a portion of certain real estate and improvements legally described on Exhibit A attached hereto and made a part hereof (the “Secured Property”); and 

B. State Farm, as a condition to making a loan to Lessor in the principal amount of
                     (the “Loan”), which is to be secured by a Mortgage and Security Agreement executed by Lessor to and in favor of
State Farm (the “Mortgage”) constituting a first lien upon and encumbering the Secured Property, and further secured by an Assignment of Rents and Leases executed by Lessor to and in favor of State Farm (the “Assignment of Rents and
Leases”) assigning to State Farm all leases of and all rents derived from the Secured Property, has required the execution of this Agreement. 

AGREEMENTS 
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements herein contained and in consideration of the sum of One Dollar ($1.00) by each of the parties hereto paid to the other, receipt and sufficiency of which are hereby acknowledged,
the parties hereto do hereby covenant, stipulate and agree as follows: 
 1. The Lease, and any and all modifications thereof and amendments
thereto, all of Lessee’s rights thereunder and Lessee’s leasehold interest and estate in the Secured Property, shall be and are hereby made junior, inferior, subordinate and subject in all respects to the lien and encumbrance of the
Mortgage on the Secured Property and to all renewals, modifications, consolidations, replacements and extensions of the Mortgage, to the full extent of the principal sum secured thereby, all interest thereon and all other sums payable or hereafter
becoming payable thereunder. 
 2. Lessee agrees that it shall promptly deliver or mail to State Farm a copy of each written notice given by
Lessee to Lessor of a default by Lessor under the Lease. Lessee further agrees that if, within the time provided in the Lease to cure defaults thereunder (or if no time period is specified in the Lease, within thirty (30) days after State
Farm’s receipt of Lessee’s written notice of default), State Farm, at its option, shall cause to be performed the obligations with respect to which Lessor is in default under the Lease, as specified in such written notice, any right of
Lessee to terminate the Lease by reason or on account of such default of Lessor shall cease and be null and void. 
 3. Lessee is advised
and hereby acknowledges that the Mortgage, Assignment of Rents and Leases and other documents which evidence and secure the Loan (collectively the “Loan Documents”) grant and provide to State Farm the right to collect rents and other sums
payable under the Lease (collectively, the “Rents”) directly from Lessee upon the occurrence of an “Event of Default” (as defined in the Mortgage) by Lessor under the Loan Documents. Lessor and Lessee hereby agree that upon
Lessee’s receipt from State Farm of written notice of the occurrence of any Event of Default by Lessor under the Loan Documents, Lessee shall thereafter pay all Rents directly to State Farm (or as State Farm shall direct). 

  
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 4. In the event State Farm shall become the owner of the Secured Property by reason of the
foreclosure of the Mortgage or the acceptance of a deed in lieu of foreclosure, provided that Lessee is not in default of its obligations under the Lease beyond any applicable grace or cure periods, State Farm agrees that Lessee shall be entitled to
continue in possession of the Secured Property undisturbed and the Lease shall not be terminated or affected thereby, but shall continue in full force and effect as a direct lease between State Farm and Lessee upon all of the terms, covenants and
conditions set forth therein. In such event, Lessee shall attorn to State Farm and State Farm shall be deemed to have accepted such attornment, whereupon, subject to the observance and performance by Lessee of all of the terms, covenants and
conditions of the Lease to be observed or performed by Lessee, State Farm shall recognize the leasehold estate of Lessee under all of the terms, covenants and conditions set forth in the Lease for the remaining balance of the term thereof; provided,
however, State Farm shall not be: 
  

	 	(a)	liable for any act or omission of any prior Lessor (including Lessor) or subject to any offsets or defenses which Lessee might have against any prior lessor (including Lessor); provided, however, the foregoing
limitation on liability shall not limit State Farm’s obligations under the Lease to correct any physical conditions that (i) exist as of the date State Farm shall become the owner of the Secured Property; and (ii) violate State
Farm’s obligations as Lessor under the Lease; provided further however, that State Farm shall have received a written notice of such acts, omissions, conditions or violations prior to becoming owner of the Secured Property and had an
opportunity to cure the same in accordance with paragraph 2 hereof. In no event, however, shall State Farm have any liability for consequential damages arising from any default occurring prior to the date State Farm acquires title to the Secured
Property; 

  

	 	(b)	bound by any rent or additional rent which Lessee might have paid in advance for more than one month; 

  

	 	(c)	bound by any amendment or modification of the Lease made after the date of this Agreement without State Farm’s prior written consent; 

 

	 	(d)	liable for any security deposit, unless actually received by State Farm from any prior lessor (including Lessor); and 

  

	 	(e)	liable for obligations under the Lease with respect to any property or facilities for the use of Lessee (such as off-site leased space or parking) other than the Secured Property and Lessee shall look solely to Lessor
for the performance and observance of any and all such obligations. 

 5. State Farm agrees that unless required by law and
provided that Lessee is not in default under the terms of the Lease beyond any applicable grace or cure periods set forth therein, State Farm will not join Lessee as a defendant in any foreclosure proceedings or other suit, action or proceeding to
enforce any rights under the Mortgage, and if such joinder is required by law, State Farm will not seek to terminate the Lease or Lessee’s possession of the Secured Property. 

6. Lessee agrees that notwithstanding anything to the contrary contained in this Agreement, in the Lease or in any other instrument, any
interest of Lessee in or under any option to purchase or right of first refusal of, or with respect to all or any part of the Secured Property is hereby specifically subordinated to the rights of State Farm under the Mortgage and other Loan
Documents and such option to purchase or right of the first refusal shall not be binding upon State Farm, its successors and assigns. 
 7.
This Agreement shall be binding upon and inure to the benefit of the parties hereto and shall also bind and benefit the heirs, legal representatives, successors and assigns of the respective parties hereto, and all covenants, conditions and
agreements herein contained shall be construed as running with the title to the land comprising the Secured Property. 
 8. Any claim by
Lessee against State Farm as a successor Lessor under the Lease or this Agreement shall be satisfied solely out of State Farm’s interest in the Secured Property and Lessee shall not seek recovery against or out of any other assets of State
Farm. 
 9. This Agreement may be executed in multiple counterparts, all of which shall be deemed originals and with the same effect as if
all parties had executed the same document. All counterparts shall be construed together and shall constitute one instrument. 

  
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 10. STATE FARM, LESSOR AND LESSEE HEREBY WAIVE TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW,
THE RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM FILED BY ANY PARTY, WHETHER IN CONTRACT, TORT OR OTHERWISE RELATING DIRECTLY OR INDIRECTLY TO THIS AGREEMENT OR ANY ACTS OR OMISSIONS OF LESSOR AND LESSEE IN CONNECTION THEREWITH
OR CONTEMPLATED THEREBY. 
 THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK 

  
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 IN WITNESS WHEREOF, the parties hereto have caused these presents to be executed as of the
day and year first above written. 
  

					
	[Witnesses, if required]	  	[Signature block for Lessor]
		
	[Witnesses, if required]	  	[Signature block for Lessee]
		
	[Witnesses, if required]	  	STATE FARM BANK, F.S.B.,
 a federal savings bank

			
		  	By:	 	  

			
		  	Its:	 	  

		
		  	Address:
		
		  	One State Farm Plaza
		  	Bloomington, Illinois 61710-0001
		  	Corporate Law-Investments
		  	Attn: (Name of Attorney)

  
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 (CHOOSE APPROPRIATE NOTARY ACKNOWLEDGMENT 

AND COMPLETE FOR LESSOR AND LESSEE) 

GENERAL PARTNERSHIP: 
  

					
	STATE OF	 	
                     
    
	 	)
	COUNTY OF	 	  
	 	)

 Before me, the undersigned, a Notary Public in and for the County and State aforesaid, personally appeared
                    , with whom I am personally acquainted (or proved to me on the basis of satisfactory evidence), and who upon oath
acknowledged himself to be of                     , a general partnership, a general partner of
                    , the within named bargainor, a
                     general partnership, and that
                     as such of the general partner, being authorized so to do, executed the foregoing instrument for the purposes therein
contained, by signing the name of the general partnership by himself as of                     , a general partner of
                    . 
 Witness
my hand and seal, at office in                     ,          this the
         day of                     , 20    . 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

 CORPORATE: 
  

					
	STATE OF	 	
                     
    
	 	)
	COUNTY OF	 	  
	 	)

 Before me,
                     the undersigned, a Notary Public in and for the County and State aforesaid, personally appeared
                    , with whom I am personally acquainted (or proved to me on the basis of satisfactory evidence), and who upon oath
acknowledged self to be                      of         , the within named bargainor, a
corporation, and that as such                      being authorized so to do, executed the foregoing instrument for the purposes therein
contained, by signing the name of the corporation by                      self as
                    . 
 Witness
my hand and seal, at office in                     ,              this the
                     day of
                    , 20    . 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

 LIMITED PARTNERSHIP: 
  

					
	STATE OF	 	
                     
    
	 	)
	COUNTY OF	 	  
	 	)

 Before me, the undersigned, a Notary Public in and for the County and State aforesaid, personally appeared
                    , with whom I am personally acquainted (or proved to me on the basis of satisfactory evidence), and who upon oath
acknowledged             self to be                      of
        , the within named bargainor, a limited partnership, and that as                     
such                     , being authorized so to do, executed the foregoing instrument for the purposes therein contained, by signing the
name of the limited partnership by                      self as
                    . 
 Witness
my hand and seal, at office in                     ,          this the
         day of                     , 20    . 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

  
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 LIMITED LIABILITY COMPANY: 

 

					
	STATE OF	 	
                     
    
	 	)
	COUNTY OF	 	  
	 	)

 Before me, the undersigned, a Notary Public in and for the County and State aforesaid, personally appeared
                    , with whom I am personally acquainted (or proved to me on the basis of satisfactory evidence), and who upon oath
acknowledged                      self to be
                     of
                    , the within named bargainor, a limited liability company, and that as
                     such
                    , being authorized so to do, executed the foregoing instrument for the purposes therein contained, by signing the name of
the limited liability company by                      self as
                    . 
 Witness
my hand and seal, at office in                     ,
                     this the          day of
                    , 20    . 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

 INDIVIDUAL: 
  

					
	STATE OF	 	
                     
    
	 	)
	COUNTY OF	 	  
	 	)

 Personally appeared before me, the undersigned, a Notary Public in and for said County and State, the within
named                     , the bargainor, with whom I am personally acquainted (or proved to me on the basis of satisfactory evidence), and
who upon oath acknowledged that executed the within instrument for the purposes therein contained. 
 Witness my hand and seal, at office in
                    ,
                     this the          day of
                    , 20    . 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

  
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 ACKNOWLEDGMENT FOR STATE FARM: 

 

					
	STATE OF ILLINOIS	  	)	  	
		  	)SS	  	
	COUNTY OF MCCELAN	  	)	  	

 COUNTY OF MCLEAN    ) 

I,                     , do hereby
certify that on the                      day of         , 20    ,
                     as
                     of State Farm Bank, F.S.B., a federal savings bank, personally appeared before me and being first duly sworn by me
severally acknowledged that they signed the foregoing document in the respective capacities therein set forth and declared that the statements therein contained are true. 

IN WITNESS WHEREOF, I have hereunto set my hand and seal the day and year before written. 

 

			
	  

	NOTARY PUBLIC	 	

 
			
	My Commission Expires:	 	  

  
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 Exhibit 10.6 

CONFIDENTIAL 
 EXECUTION COPY

 JOINT DEVELOPMENT & LICENSE AGREEMENT 

This Joint Development and License Agreement (this “Agreement”) is made as of the 31st day of December 2012 (the “Effective Date”), by and between Pfenex, Inc., a Delaware corporation with a principal place of business located at 10790 Roselle Street, San Diego, CA
92121 (“Pfenex”), and Agila Biotech Private Limited, company incorporated under the Companies Act, 1956 and having its registered office at Strides House, Bilekahalli, Bannerghatta Road, Bangalore 560 076, India
(“Agila”). Pfenex and Agila may be referred to individually as a “Party” or together as the “Parties.” 

BACKGROUND 
 A. Pfenex has a
proprietary Pseudomonas fluorescens protein expression platform (as further defined below as the “Pfenex Expression Technology”), which is used to increase yield, accelerate the development and production of biotherapeutics
and vaccines; 
 B. Agila is engaged in the business of manufacturing and supplying therapeutic biological products for research and development and
commercial purposes; 
 C. Pfenex and Agila desire to collaborate with each other, to develop certain therapeutic biological products manufactured using the
Pfenex Expression Technology through the completion of the first Phase I Clinical Trial (as defined below) for each such product in accordance with the terms and conditions of this Agreement; 

D. Pfenex and Agila wish to establish a joint venture company (the “JVC”) to further develop and commercialize one or more such products
after the completion of the first Phase I Clinical Trial pursuant to a separate Joint Venture Agreement to be entered into by the Parties (the “JVA”) as set forth in Section 3.8; and 

E. Upon successful completion of the first Phase I Clinical Trial in the Territory for such a product and the JVC’s receipt of all necessary Consents,
business licenses and governmental approvals, and contingent upon the Parties’ agreement on a plan and budget for the further development and commercialization of such product, such product and all associated data, rights and assets will be
transferred to the JVC and the JVC will continue the development and commercialization of such product as further provided in the JVA. 
 NOW, THEREFORE, in
consideration of the mutual covenants and promises herein contained and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged by the Parties, the Parties agree as follows: 

Article 1 
 DEFINITIONS

 1.1 “Act” means the Drugs and Cosmetics Act, 1940. 

1.2 “Affiliate” means, with respect to a Party, any Person controlling, controlled by or under common control with such
Party, for so long as such control exists. For 

 
the purposes of this definition, “control” means: (a) to possess, directly or indirectly, the power to direct the management and policies of such Person, whether through ownership
of voting securities or by contract relating to voting rights or corporate governance; or (b) ownership of more than fifty percent (50%) of the voting securities in such Person (or such lesser percent as may be the maximum that may be
owned pursuant to Applicable Laws of the country of incorporation or domicile, as applicable). For clarity, for purposes of this Agreement, the JVC shall not be deemed an Affiliate of either Party. 

1.3 “Analytical Methods” means, with respect to a Collaboration Product, a comprehensive set of analytical methods used to
test the quality of in-process, bulk drug substance(s) and drug product(s) for the applicable Collaboration Product. 
 1.4
“Applicable Laws” means any laws, statutes, rules, regulations, guidelines, and standards promulgated by any governmental authority of competent jurisdiction applicable to the Parties or the activities contemplated hereunder,
together with any judgments, orders, notices, instructions, decisions, standards, guidance and awards, each having the force of law, issued by a court or competent authority or tribunal or a Regulatory Authority to which the applicable Party is
subject, including, as applicable, GCP, GLP, GMP, the Act and the Rules. 
 1.5 “Background Technology” means, with respect
to a Party, any and all technology, know-how, technical information and other technical subject matter, and all intellectual property rights therein, in each case Controlled by such Party as of the Effective Date or otherwise developed or acquired
by or on behalf of such Party outside the performance of this Agreement, in each case that are necessary for the performance of any Development Plan under this Agreement. For clarity, Pfenex’s Background Technology includes the Pfenex
Expression Technology, including to the extent it is embodied in the Pfenex Materials and Deliverables. 
 1.6 “Collaboration
Product(s)” means, individually and collectively, any product for which the Parties establish and sign a Development Plan pursuant to Section 3.1 for development hereunder, which may include but not limited to: 

(a) Interferon beta-1b as a biosimilar product to the innovator product Betaseron®/Betaferon® from Bayer HealthCare Pharmaceuticals;

 (b) PEGylated Interferon beta-1b; 

(c) PEGylated Granulocyte Colony-Stimulating Factor (PEG-GCSF) as a biosimilar product to the innovator product Neulasta® from Amgen
Inc.; 
 (d) PEGylated L-Asparaginase as a biosimilar product to Oncaspar® from Sigma-Tau Pharmaceuticals Inc.; and 

(e) Human Growth Hormone (HGH) as a biosimilar product to Genotropin® from Pfizer Inc. 

1.7 “Consents” means any consent, license, approval, authorization, waiver, permit, grant, concession, agreement, license,
certificate, exemption, order or registration, of or with any Person. 

  
 -2- 

 1.8 “Control” means the possession (whether by ownership, license or other
authorization), as of the Effective Date or during the Term, of (a) with respect to materials, data or information, physical possession or the right to such physical possession of those items, and the right to provide them to others (including
the other Party); and (b) with respect to intellectual property rights, the right sufficient to grant the applicable license or sublicense under this Agreement; in each case without violating the terms of any agreement with any Third Party.
Notwithstanding anything to the contrary in this Agreement, the following shall not be deemed to be Controlled by a Party: (i) any materials, data, information or intellectual property owned or licensed by any Acquiring Entity immediately prior
to the effective date of merger, consolidation or transfer, and (ii) any materials, data, information or intellectual property that any Acquiring Entity subsequently develops independently, without accessing or practicing the Pfenex Background
Technology (in the case of an Acquiring Entity of Pfenex) or the Agila Background Technology (in the case of an Acquiring Entity of Agila). For the purpose of this Section 1.8, “Acquiring Entity” means, with respect to a Party,
a Third Party that merges or consolidates with or acquires such Party, or to which such Party transfers all or substantially all of its assets to which this Agreement pertains. “Controlled” has its corollary meaning. 

1.9 “Facility” means (a) each GMP-compliant facility jointly identified by both Parties for manufacturing (including
storing and handling) any Collaboration Product for Phase I Clinical Trials, (b) Agila’s GMP-compliant Pilot Plant located at [*] and (c) Agila’s GMP-compliant manufacturing facility under construction at the [*] (the
“[*] Facility”), only when all applicable testing and validation of such facility has been successfully completed, and all required Consents have been obtained, and such facility is otherwise ready and available for use in
manufacture of Collaboration Products. 
 1.10 “GCP” means the then-current FDA regulations and guidelines for “Good
Clinical Practice,” as promulgated by the FDA under 21 CFR Parts 50, 54, 56 and 312, as amended from time to time, or any foreign equivalents thereto (e.g., ICH Guideline for Good Clinical Practice) in the country in which the applicable Phase
I Clinical Trial is conducted. 
 1.11 “GMP” means the then-current Good Manufacturing Practices pursuant to the U.S. Food,
Drug and Cosmetic Act and any U.S. regulations found in Title 21 of the U.S. Code of Federal Regulations (including Parts 11, 210 and 211 and the provisions of the Act and the Rules) and comparable laws, rules and regulations applicable to the
manufacture, labeling, packaging, handling, storage, supply and transport of any Collaboration Product in any jurisdiction where the applicable Collaboration Product is or may be utilized in humans hereunder. 

1.12 “GLP” means the then-current FDA regulations and guidelines for “Good Laboratory Practice,” as promulgated by
the FDA under Title 21 of the U.S. Code of Federal Regulations Part 58, as amended from time to time, or any foreign equivalents thereto in the country in which research is conducted hereunder. 

1.13 “Manufacturing Process” means, with respect to a Collaboration Product, the process based on the Pfenex Expression
Technology for the production of such Collaboration Product using the associated Manufacturing Strain, as such process may be amended from time to time by the Parties pursuant to Section 5.2 below. 

  
 -3- 

 1.14 “Manufacturing Strain” means, with respect to a Collaboration Product, a
strain of Pseudomonas fluorescens incorporating a nucleic acid sequence that is optimized to express the protein that is the active ingredient of such Collaboration Product. 

1.15 “Master Cell Bank” means a cell bank produced from the Research Cell Bank for a Collaboration Product that complies with
(a) GMP requirements for cell banks used in the production of biological products for use in humans and (b) the specifications therefor as set forth in the Development Plan for such Collaboration Product, a portion of which is anticipated
to be deposited with a Third Party vendor for storage and preservation and which cell bank may be used in the establishment of the Working Cell Bank for such Collaboration Product. 

1.16 “PEGylation” means the process of covalent attachment of polyethylene glycol (PEG) polymer chains to another molecule.
“PEGylated” shall have its correlative meanings. 
 1.17 “Person” means any individual, corporation,
partnership, limited liability company, trust, business trust, association, joint-stock company, joint venture, pool, syndicate, sole proprietorship, unincorporated organization, government authority or any other form of entity not specifically
listed herein. 
 1.18 “Pfenex Expression Technology” means Pfenex’ proprietary Pseudomonas fluorescens
expression platform technology used in the development and production of biological products, including through the optimization of a nucleic acid sequence and development of the associated manufacturing cell strains to express such product,
together with all intellectual property rights therein. 
 1.19 “Phase I Clinical Trial” means a clinical development
program that provides for the first introduction into humans of a pharmaceutical product with the primary purpose of making a preliminary determination with respect to safety, metabolism and pharmacokinetic properties and clinical pharmacology of
such pharmaceutical product in healthy patients, or otherwise generally consistent with 21 C.F.R. §312.21(a). 
 1.20 “Phase
III Clinical Trial” means any human clinical trial conducted in any country on a sufficient numbers of patients that is designed, if the defined end-points are met, to establish safety and efficacy of a pharmaceutical product in patients
with the indication being studied for purposes of filing a marketing approval application or to otherwise be a pivotal trial for obtaining a marketing approval or label expansion for such pharmaceutical product or otherwise generally consistent with
21 C.F.R. §312.21(c). 
 1.21 “Raw Materials” means, with respect to any Collaboration Product(s), any and all
ingredients, including media, buffers, solvents and other components (excluding the Manufacturing Strain as provided under Section 4.1.1 below) used in the manufacture of such Collaboration Product hereunder in accordance with the Manufacturing
Process and Specifications for such Collaboration Product. 

  
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 1.22 “Regulatory Approval” means all approvals, licenses, clearances,
registrations or authorizations received from any Regulatory Authority in response to a Regulatory Filing together with all necessary approvals by any regulatory advisory board (e.g. institutional review board and ethics committee). 

1.23 “Regulatory Authority” means any federal, national, multinational, state, provincial or local regulatory agency,
department, bureau or other governmental entity with authority over the development, manufacture or other commercialization (including the granting of Regulatory Approvals) of any Collaboration Product in any jurisdiction, including the Drugs
Controller General of India, European Medicines Agency and the United States Food and Drug Administration (“FDA”), in each case, any successor entity thereto. 

1.24 “Regulatory Filings” means any submission made to a Regulatory Authority with respect to a pharmaceutical or medicinal
product, including any application necessary to commence or conduct clinical testing of such product in humans, any submission to a regulatory advisory board with respect to such product, and in each case any supplement or amendment to any of the
foregoing. 
 1.25 “Research Cell Bank” means a non GMP cell bank of the Manufacturing Strain for a Collaboration Product
meeting the specifications therefor as set forth in the Development Plan for such Collaboration Product. 
 1.26 “Rules”
means the Drugs and Cosmetic Rules, 1945. 
 1.27 “Study Results” means any and all data, results and reports from any
preclinical or clinical studies with respect to any Collaboration Product conducted hereunder, including all data, results and reports from each Phase I Clinical Trial conducted hereunder and all interim reports and the final report generated
therefrom. 
 1.28 “Specifications” means, with respect to a Collaboration Product, those specifications, manufacturing
guidelines, control procedures, acceptance criteria, validation protocols, packaging, storage and release requirement or procedures or other similar requirements for the manufacture of such Collaboration Product, as mutually agreed by the Parties
and set forth in the applicable Development Plan. 
 1.29 “Successful Completion” means, with respect to a Phase I Clinical
Trial, the meeting of primary endpoints set forth in the applicable protocol approved by the JSC and the submission of the final trial report to the applicable Regulatory Authority as required under Applicable Law. 

1.30 “Territory” means worldwide. 

1.31 “Third Party” means an entity other than Pfenex, Agila and their respective Affiliates. 

1.32 “Working Cell Bank” means a cell bank of the Manufacturing Strain produced from the Master Cell Bank for a Collaboration
Product that complies with (a) GMP requirements for cell banks used in the production of biological products for use in humans and (b) the specifications therefor as set forth in the Development Plan for such Collaboration Product. 

  
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 1.33 Additional Defined Terms. Each of the following terms shall have the meaning
described in the corresponding section of this Agreement indicated below: 
  

			
	Term	  	Section Defined
	Agila Improvements	  	10.5
	Alliance Manager	  	2.6
	Co-Chair	  	2.2
	Collaboration Technology	  	10.3
	Confidential Information	  	9.1
	Development Plan	  	3.1
	Indemnitee	  	13.3
	Indemnitor	  	13.3
	JSC	  	2.1
	JVA	  	Background
	JVC	  	Background
	Milestone	  	8.1
	Pfenex Improvements	  	10.4
	Pfenex Materials and Deliverables	  	4.1.1
	Plan and Budget	  	3.9
	Prior Confidentiality Agreement	  	9.5
	SIAC	  	14.9.2
	Subcommittee	  	2.7
	Term	  	11.1

 1.34 Interpretation. The captions and headings to this Agreement are for convenience only, and are to
be of no force or effect in construing or interpreting any of the provisions of this Agreement. Unless specified to the contrary, references to Articles, Sections or Exhibits means the particular Articles and Sections of or Exhibits to
this Agreement, and references to this Agreement include all Exhibits hereto. Unless context clearly requires otherwise, whenever used in this Agreement: (a) the words “include” or “including” shall be construed as
incorporating, also, “but not limited to” or “without limitation;” (b) the word “or” shall have its inclusive meaning of “and/or;” (c) the word “day” or “quarter” or
“year” means a calendar day or calendar quarter or calendar year unless otherwise specified; (d) the word “notice” shall require notice in writing (whether or not specifically stated) and shall include notices, consents,
approvals and other written communications contemplated under this Agreement; (e) the words “hereof,” “herein,” “hereunder,” “hereby” and derivative or similar words refer to this Agreement (including any
Exhibits); (f) provisions that require that a Party or the Parties hereunder “agree,” “consent” or “approve” or the like shall require that such agreement, consent or approval be specific and in writing, whether by
written agreement, letter or otherwise; (g) words of any gender include the other gender; (h) words using the singular or plural number also include the plural or singular number, respectively; (i) references to any specific law, or
article, section or other division thereof, shall be deemed to include the then-current amendments thereto or any replacement thereof; and (j) provisions that refer to Persons acting “under the authority of Pfenex” shall include
Pfenex’s Affiliates or licensees, as 

  
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applicable, and those Persons acting “under the authority of Agila” shall include Agila’s Affiliates or sublicensees, as applicable; conversely, those Persons acting “under
the authority of Pfenex” shall exclude Agila, its Affiliates and sublicensees, as applicable, and those Persons acting “under the authority of Agila” shall exclude Pfenex, its Affiliates and licensees, as applicable. 

Article 2 
 GOVERNANCE

 2.1 JSC Establishment. Within thirty (30) days of the Effective Date, the Parties agree to establish a joint steering
committee (“JSC”) for the overall coordination and oversight of the Parties’ activities under this Agreement. 
 2.2
JSC Membership. The JSC shall be comprised of an equal number of representatives from each of Pfenex and Agila, with at least two (2) representatives from each Party. Either Party may replace its respective JSC representatives at any
time with prior written notice to the other Party, provided that such replacement has comparable authority and scope of functional responsibility within that Party’s organization as the individual he or she is replacing. Without limiting the
foregoing, each Party shall appoint by notice to the other Party one of its members to the JSC as a co-chair of the JSC (each, a “Co-Chair”). The Co-Chairs shall (a) coordinate and prepare the agenda and ensure the orderly
conduct of the JSC’s meetings, (b) attend (subject to below) each meeting of the JSC, and (c) prepare and issue minutes of each meeting within ten (10) business days thereafter accurately reflecting the discussions and decisions
of the JSC at such meeting. Such minutes from each JSC meeting shall not be finalized until a member from each Party has reviewed and approved the accuracy of such minutes in writing. The Co-Chairs shall solicit agenda items from the other JSC
members and provide an agenda along with appropriate information for such agenda reasonably in advance (to the extent possible) of any meeting. In the event the presiding Co-Chair or another member of the JSC from either Party is unable to attend or
participate in any meeting of the JSC, the Party who designated such member may designate a substitute representative for the meeting. 

2.3 JSC Responsibilities. The role of the JSC shall be: 

2.3.1 to review and approve the Development Plan for any Collaboration Product(s) and any amendment thereto; 

2.3.2 to coordinate and oversee the transfer of Pfenex Materials and Deliverables to Agila; 

2.3.3 to manage and oversee the implementation of the Development Plan for any Collaboration Product(s), including all regulatory activities
required or otherwise conducted in accordance therewith; 
 2.3.4 to monitor each Phase I Clinical Trial conducted pursuant to the
Development Plan for the respective Collaboration Product(s); 

  
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 2.3.5 to provide a forum for the Parties to exchange information with respect to matters
pertaining to and status of the performance of the Development Plan for any Collaboration Product(s); 
 2.3.6 to coordinate and oversee
the transfer of any Collaboration Product(s) to the JVC pursuant to Section 3.9; and 
 2.3.7 to perform such other functions as
appropriate to further the purposes of this Agreement, as expressly set forth hereunder or otherwise agreed in writing by the Parties. 

2.4 JSC Meetings. 

2.4.1 Conduct. During the Term, the JSC shall hold at least one (1) meeting per calendar quarter in accordance with a schedule
established in advance annually or as the JSC otherwise agrees. Meetings of the JSC shall be effective only if at least one (1) representative of each Party is present or participating. The JSC may meet either (a) in person at either
Party’s facilities or at such locations as the Parties may otherwise agree; or (b) by audio or video teleconference; provided that at least one (1) such meeting per year shall be in person. With the prior consent of the other
Party’s representatives (such consent not to be unreasonably withheld or delayed), each Party may invite non-member employees to participate in the discussions and meetings of the JSC, provided that such participants shall have no vote and
shall be subject to the confidentiality provisions set forth in Article 9 of this Agreement. Additional meetings of the JSC may also be held with the mutual consent of the Parties, or as required under this Agreement, and neither Party will
unreasonably withhold or delay its consent to hold any such additional meeting. Each Party shall be responsible for all of its own expenses incurred in connection with participating in the JSC. 

2.4.2 Progress Report. At each meeting of the JSC, each Party shall summarize to the JSC the progress of the activities performed by
or under authority of such Party and its Affiliates with respect to each Collaboration Product during the period since the last meeting of the JSC. 

2.5 JSC Decision Making. Decisions of the JSC shall be made by consensus, with each Party having one (1) vote. Each Party shall
act in good faith to reach consensus on all matters and act in the general spirit of cooperation and in no event shall either Party unreasonably withhold, condition or delay any approval or other decision of the JSC hereunder. In the event the JSC
fails to reach consensus with respect to a particular matter within its authority, then upon request by either Party such matter shall be resolved pursuant to Section 14.10. For clarity, the JSC shall not have the power to amend or modify this
Agreement, and no decision of the JSC shall be in contravention of any terms or conditions of this Agreement. It is understood and agreed that issues to be formally decided by the JSC are only those specific issues that are expressly provided in
this Agreement or otherwise mutually agreed by the Parties to be decided by the JSC. 
 2.6 Alliance Manager. Promptly after the
execution of this Agreement each Party shall appoint a single individual to act as the primary point of contact between the Parties 

  
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in connection with the performance of the Development Plans (each, an “Alliance Manager”). Each Party may at any time appoint a different Alliance Manager by written notice to
the other Party and may elect, upon mutual agreement by the Parties, to eliminate the responsibilities of the Alliance Managers. The Alliance Managers shall be entitled to attend meetings of the JSC, but shall not have, or be deemed to have, any
rights or responsibilities of a member of the JSC. Each Alliance Manager may bring any matter to the attention of the JSC where such Alliance Manager reasonably believes that such matter requires such attention. 

2.7 Subcommittees. Promptly after the establishment of the JSC, the JSC shall establish the following subcommittees (each, a
“Subcommittee”): (a) a preclinical, clinical and regulatory Subcommittee to coordinate and make all day-to-day decisions necessary to implement any preclinical or clinical studies and regulatory activities set forth in each
Development Plan; (b) a chemistry, manufacturing, and controls (CMC) Subcommittee to coordinate and make all day-to-day decisions necessary to implement any manufacturing-related activities set forth in each Development Plan; (c) a
commercialization Subcommittee to (i) propose business/ commercialization strategies and priorities with respect to the Collaboration Products for the review and approval of the JSC and (ii) coordinate and resolve any issue arising from
the performance of each Development Plan that may impact such business/commercialization strategy for any Collaboration Product; (d) an intellectual property Subcommittee to develop and implement the intellectual property strategy with respect
to Collaboration Technology and coordinate the prosecution and maintenance of patents and patent applications claiming any jointly owned Collaboration Technology; and (e) a Subcommittee to oversee and coordinate the transfer of various
technologies as contemplated herein, whether between the Parties or to a Third Party. Each Subcommittee shall consist of equal number of representatives of each Party and shall meet with such frequency as the JSC determines is appropriate. Each
Subcommittee shall be responsible for day-to-day implementation and operations of the activities under this Agreement for which it has or is otherwise assigned responsibility, provided that such implementation is not inconsistent with the express
terms of this Agreement, the applicable Development Plan or the decisions of the JSC. Each Subcommittee shall operate by unanimous vote in all decisions, with each Party having one (1) vote and with at least one (1) representative from
each Party participating in such vote. If, with respect to a matter that is subject to a Subcommittee’s decision-making authority, the Subcommittee cannot reach unanimity, the matter shall be referred to the Alliance Manager, who shall submit
such matter to the JSC for resolution in accordance with Section 2.5. The various Subcommittees may have overlapping membership and the Parties will attempt to time meetings of the JSC and the various Subcommittees to maximize productivity of
the members and minimize costs associated therewith. 
 Article 3 

PRODUCT DEVELOPMENT 

3.1 Development Plan. Promptly after the execution of this Agreement, on a Collaboration Product-by-Collaboration Product basis, Pfenex
and Agila shall jointly prepare a mutually-agreed written work plan for any Collaboration Product(s) that sets out in reasonable detail the development activities to be conducted by each Party and its designees for the Successful Completion of the
first Phase I Clinical Trial for any Collaboration Product(s), as well as the location, protocol, budget and timelines for completion of various tasks therefor 

  
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(each, a “Development Plan”). Each Development Plan shall be subject to the JSC’s approval. Upon the JSC’s approval of a Development Plan, such Development Plan shall
be signed by a duly authorized representative from each Party and attached hereto as a part of this Agreement. For the avoidance of doubt, unless and until the Parties sign the Development Plan for any Collaboration Product, neither Party shall have
any obligation with respect to any product hereunder; provided, however, that unless and until the earlier of (a) the Parties sign a Development Plan therefor or (b) either Party provides sixty (60) days’ prior written notice to
the other Party of its intent to exclude a product described in Section 1.6(a) — (e), the Parties shall use good faith efforts to prepare and agree on Development Plan therefor prior to the date specified in Exhibit 1 (as may
be amended from time to time by the Parties). Each Development Plan will be updated and approved semi-annually by the JSC and shall be consistent with the general allocation of responsibilities described in Section 3.2 below. Without limiting
the foregoing, any material modifications or additions to any Development Plan (including any proposed change(s) to any Third Party designee) shall be first approved by JSC prior to its implementation. Each Party shall perform its obligations
allocated to it under each Development Plan in accordance with the terms and conditions of this Agreement (including the diligence requirement set forth in Article 8), the applicable Development Plan and all Applicable Laws. 

3.2 General Allocation of Responsibilities. 

3.2.1 To Pfenex. As further provided in the applicable Development Plan, with respect to each Collaboration Product, Pfenex shall be
responsible for and shall bear the expenses of: 
 (a) establishing and characterizing a Research Cell Bank for such Collaboration Product
(and in the case of the Interferon beta-1b Collaboration Product only, an initial Master Cell Bank and Working Cell Bank); 
 (b)
developing Manufacturing Process and Analytical Methods for such Collaboration Product; 
 (c) transferring the Research Cell Bank,
Manufacturing Process and Analytical Methods for such Collaboration Product to Agila along with copies of existing documentation associated therewith; 

(d) providing technical assistance to Agila with respect to Agila’s use thereof in accordance with and during the Term; and 

(e) providing assistance to Agila to apply for any funding/grants from any national (Indian), international or other sources for the
development of such Collaboration Product. 
 3.2.2 To Agila. As further provided in the applicable Development Plan, with respect
to each Collaboration Product, Agila shall be responsible for and shall bear the expenses of: 
 (a) establishing and characterizing a
Master Cell Bank and Working Cell Bank for the production of such Collaboration Product (except in the case of the Interferon beta-1b Collaboration Product only, for which Pfenex will be responsible for establishing and characterizing the initial
Master Cell Bank and Working Cell Bank); 

  
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 (b) transferring a portion of the Master Cell Bank to a mutually agreed Third Party for storage
and preservation; 
 (c) performing any necessary formulation development for such Collaboration Product; 

(d) performing any necessary scale up and validation activities and implementing the GMP manufacturing of such Collaboration Product; 

(e) performing the proper stability studies and analytical, process and shipping validation for such Collaboration Product in accordance with
GMP; 
 (f) developing and performing any necessary PEGylation process for such Collaboration Product; 

(g) obtaining and maintaining appropriate Consents including facility permits, manufacturing licenses, manufacturing and analytical records
and approvals necessary for the manufacture of such Collaboration Product; 
 (h) performing any necessary GLP toxicology study for such
Collaboration Product and provide sufficient amount of such Collaboration Product for other preclinical studies and the first Phase I Clinical Trial; 

(i) managing regulatory matters (including making all Regulatory Filings with Regulatory Authorities for obtaining all necessary Regulatory
Approvals to initiate the first Phase I Clinical Trial for such Collaboration Product); and 
 (j) conducting the first Phase I Clinical
Trial for such Collaboration Product and undertake other actions necessary for the Successful Completion of such Phase I Clinical Trial; and 

(k) applying for funding/grants from any national (Indian), international or other sources for the development of such Collaboration Product,
with the assistance of Pfenex. 
 3.3 Development Costs. As between the Parties, each Party shall bear all of the costs and expenses
incurred in connection with any of the activities allocated to such Party under this Agreement and each applicable Development Plan. Notwithstanding anything to the contrary in this Agreement or any Development Plan, Agila shall be responsible for
all costs and expenses incurred by the Parties in conducting the first Phase I Clinical Trial of any Collaboration Product hereunder. Notwithstanding the foregoing, neither Party may commit to, enter into any agreement for the conduct of a Phase I
Clinical Trial or manufacturing agreement under the Development Plan(s) for any Collaboration Product(s) except as approved by the JSC; provided, however, Agila will reimburse Pfenex for those costs incurred in connection for the Phase I Clinical
Trial for the Interferon beta-1b Collaboration Product (including the GMP manufacture of such Collaboration Product therefor) as set forth on Exhibit 2. 

  
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 3.4 Subcontractors. Except as set forth in the applicable Development Plan, neither Party
may subcontract or otherwise delegate all or any portion of its obligations under this Agreement (including substituting or adding manufacturing or contract research facilities of a Third Party) without JSC’s prior written approval. When
considering a subcontractor a Party will advise the JSC, which will establish an audit team comprised of members from each Party to audit or review such subcontractor to ensure that the subcontractor meets the qualifications necessary and has
complied with Applicable Laws with respect to the subcontracting activities for which such subcontractor is being considered. To the extent such approval is granted, the subcontracting Party shall (a) ensure that each such subcontractor has and
maintains all appropriate qualifications and complies with Applicable Laws and that the other Party or its designee has the right to participate in and approve such qualification process; (b) ensure that all such approved subcontractors comply
with the provisions of this Agreement; and (c) be responsible for each such subcontractor’s performance hereunder (including, without limitation, any breach of this Agreement by such subcontractor), as if such subcontracting Party were
itself performing such activities. For clarity, each Party may exercise its rights or perform its obligations under this Agreement through one or more of its Affiliates; provided that each Party shall ensure that each such Affiliate complies with
the provisions of this Agreement and be responsible for each such Affiliate’s performance hereunder (including, without limitation, any breach of this Agreement). 

3.5 Protocols. All protocols for any pre-clinical or clinical studies to be performed with respect to each Collaboration Product shall
be developed by the relevant Subcommittee, in consultation with those relevant scientific/technical representatives from each Party, and submitted to the JSC for its review and approval. Further, any material modification to any such protocol shall
subject to the review and approval of the JSC. For the avoidance of doubt, all study sites and investigators for each Phase I Clinical Trial of any Collaboration Product conducted under this Agreement shall be included in the applicable Development
Plan and subject to the review and approval of the JSC. 
 3.6 Information Sharing. On an annual basis or as the JSC otherwise
determines during the Term, and without limiting Section 2.4.2, each Party shall provide to the other Party the documentation, reports and other data from or relating to any completed or ongoing development activities and the results thereof
(and summaries of any results in English if such documentation and materials are not provided in English) controlled by such Party relating to each Collaboration Product (including documentation relating to Regulatory Filings and Regulatory
Approvals, original source data, reports, case report forms (CRFs) and summary literature). Each Party shall have the right to use, and disclose (provided that if such information is the Confidential Information of the other Party, such disclosure
shall be subject to confidentiality obligations as set forth in Article 9 of this Agreement) such information to the extent necessary to exercise its rights and fulfill its obligations hereunder. 

3.7 Exclusivity of Efforts. On a Collaboration Product-by-Collaboration Product basis, during the Term for the applicable Collaboration
Product, each Party agrees that, except for its obligations hereunder, neither it nor any of its Affiliates shall develop, 

  
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manufacture, supply or commercialize any Collaboration Product, or assist any Third Party to perform any such activities with respect to any Collaboration Product. In addition, neither Party
shall, during or after the Term, use any Study Results other than pursuant to this Agreement or the JVA. Notwithstanding the foregoing, nothing herein is intended to require a Party to breach those obligations set forth in Exhibit 3
under such Party’s name. 
 3.8 Execution of the JVA. As soon as practicable after the execution of this Agreement, the Parties
shall finalize and execute the JVA by no later than February 28, 2013. It is understood that the JVA will be in the form under negotiations by the Parties as of the Effective Date, except that the Parties may (i) change the jurisdiction of
incorporation of the JVC as mutually agreed by the Parties, (ii) make other changes to the extent necessary or appropriate to comply with applicable laws of the jurisdiction of incorporation of the JVC, and (ii) modify those tax-related
provisions for the purpose of minimizing each Party’s tax liabilities arising from its activities under the JVA to the extent legally permissible. 

3.9 Collaboration Product Transfer to the JVC. On a Collaboration Product-by-Collaboration Product basis, reasonably in advance of the
anticipated completion of the first Phase I Clinical Trial for a Collaboration Product, the Parties shall, through the JSC, discuss and develop a detailed development plan and budget setting forth in reasonable detail the activities to be conducted
by the JVC for the further development and commercialization of such Collaboration Product and associated budget and timelines, including the strategy for conducting Phase III Clinical Trials for such Collaboration Product, the location for such
trials, the contract research organizations to conduct such trials and the budget therefor, as well as the launch strategy for such Collaboration Product and budget therefor (each, a “Plan and Budget”). Upon Successful Completion of
the first Phase I Clinical Trial in the Territory for a Collaboration Product and the JVC’s receipt of all necessary Consents, business licenses, permits and Regulatory Approvals, and further contingent upon the Parties’ agreement on the
applicable Plan and Budget and the JVC board of director’s ratification thereof, such Collaboration Product will be transferred to the JVC, and the JVC will continue the development and commercialization of such Collaboration Product in
accordance with the applicable Plan and Budget as further provided in the JVA. The Parties shall conduct no further development activities with respect to a Collaboration Product under this Agreement after such Collaboration Product is transferred
to the JVC. 
 Article 4 

PFENEX DELIVERABLES 

4.1 Delivery of Manufacturing Strain; Restrictions. 

4.1.1 Delivery. With respect to each Collaboration Product, promptly after Pfenex has established (a) Research Cell Bank,
(b) Manufacturing Process and (c) Analytical Methods for such Collaboration Product, Pfenex shall deliver to Agila the Manufacturing Process and the associated Research Cell Bank, Analytical Methods for the production of such Collaboration
Product (all such deliverables (including in the case of the Interferon beta-1b Collaboration Product only, an initial Master Cell Bank and Working Cell Bank) together with all modifications or derivatives thereof based in whole or part from the
Pfenex Expression Technology, collectively referred to as the “Pfenex Materials and  

  
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Deliverables”). Pfenex Materials and Deliverables shall be and remain the sole and exclusive property of Pfenex and the physical possession of such Pfenex Materials and Deliverables
by Agila shall not be (nor be construed as) a sale, lease, offer to sell or lease, or other transfer of title of such materials to Agila. Except as expressly provided in this Agreement, no licenses or rights shall be deemed granted to Agila, by
implication, estoppel or otherwise, by the transfer of physical possession of any such Pfenex Materials and Deliverables to Agila. 
 4.1.2
Limitations on Use and Transfer. Agila shall not use the Pfenex Materials and Deliverables for any purpose other than for the performance of its obligations under this Agreement. Except as otherwise authorized by Pfenex in writing, Agila
shall not provide the Pfenex Materials and Deliverables to any Person other than to approved subcontractors in furtherance of Section 3.4 or those employees of Agila who require access to the Pfenex Materials and Deliverables, in each case for
the performance of the activities allocated to Agila under any Development Plan. Agila shall only use the Pfenex Materials and Deliverables in compliance with all Applicable Laws. 

4.1.3 No Modification or Derivation. Except as (a) expressly set forth in the applicable Development Plan or (b) allowed
with Pfenex’s prior written consent, Agila shall not attempt to alter or modify the Pfenex Materials and Deliverables in any way, or to make any derivatives or modifications thereof and shall not under any circumstances attempt, directly or
indirectly, to analyze, characterize, reverse engineer or otherwise derive the sequences, or constructs of the Pfenex Materials and Deliverables. It is understood that from time to time with Pfenex’s prior consent, Agila may modify the Pfenex
Materials and Deliverables so as to improve the performance thereof. 
 4.1.4 Care in Use of the Pfenex Materials and Deliverables.
Agila acknowledges that the Pfenex Materials and Deliverables are experimental in nature and may have unknown characteristics and therefore agrees to use prudence and all reasonable care in the use, handling, storage, containment, transportation and
disposition of the Pfenex Materials and Deliverables. 
 4.2 Warranties Regarding Pfenex Materials and Deliverables. Pfenex hereby
represents and warrants to Agila that (a) Pfenex owns or has rights to the Pfenex Materials and Deliverables; (b) Pfenex has the right to provide the Pfenex Materials and Deliverables to Agila for use in accordance with this Agreement and
(c) the Pfenex Materials and Deliverables meet the written specifications therefor as set forth in the applicable Development Plan(s) at the time of delivery to Agila. 

4.3 Acknowledgement. Agila acknowledges that the use or modification of the Pfenex Materials and Deliverables other than as permitted
under this Agreement could cause irreparable damage to Pfenex. As such, Agila agrees that: (a) any breach of this Article 4 shall be considered a material breach of this Agreement; (b) Pfenex shall have the right to receive an assignment
of all right, title and interest in and to any patent or patent application that contains, discloses or claims any invention arising from an impermissible modification or use of the Pfenex Materials and Deliverables, and (c) the remedies set
forth in subsections (a) and (b) shall not prejudice Pfenex’s right to pursue any legal or equitable remedy available to Pfenex for any violations of this Article 4. 

  
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 Article 5 

MANUFACTURING OF COLLABORATION PRODUCTS 

5.1 General. As between the Parties, Agila shall be solely responsible for manufacturing any Collaboration Product(s) for any
pre-clinical studies, the first Phase I Clinical Trial for any Collaboration Product(s) and otherwise in support of the Development Plan therefor at its own costs in the Facilities. All Collaboration Product(s) supplied by Agila hereunder for use in
any Phase I Clinical Trial shall meet the applicable Specifications therefor and shall be manufactured at the Facility in accordance with the applicable Manufacturing Process and all Applicable Laws (including GMP). Agila shall perform quality
control procedures reasonably necessary to ensure that any Collaboration Product(s) for use in any clinical studies conform fully to the applicable Specifications. 

5.2 Changes. Once transferred to Agila, neither Party shall make any changes to the Manufacturing Process, Specifications, Analytical
Methods, Facility, Raw Materials or any other item in any manner that would reasonably cause any Collaboration Product for use in any clinical studies not to comply with the Specifications therefor or Applicable Laws, without the JSC’s prior
written approval. If either Party desires any such change, it may request such change through the JSC. All such changes shall be documented in a writing signed by an authorized representative of each of Pfenex and Agila. 

5.3 Deviations. Without limiting Section 5.2 above, in the event any material deviations occur during the course of the
manufacture of any batch of any Collaboration Product for use in any clinical studies under this Agreement, Agila shall immediately provide the JSC with a detailed written description of such deviation. In addition, Agila shall undertake all
reasonable and appropriate actions to investigate the cause of such deviation and to correct the same. 
 5.4 Agila Warranties. Agila
represents and warrants that: 
 5.4.1 Collaboration Product. All Collaboration Product supplied by Agila hereunder shall comply
with all Applicable Laws, GMPs and meet all Specifications, and Agila shall perform and document all manufacturing and supply activities contemplated herein in compliance with all Applicable Laws. 

5.4.2 Facilities and Equipment. The Facility(ies), all equipment used for the manufacture of each Collaboration Product within the
Facility(ies) and the activities contemplated herein complies with all Applicable Laws and Agila shall obtain and maintain all Consents including governmental registrations, permits, licenses and approvals necessary for Agila to manufacture each
Collaboration Product, and otherwise to perform its obligations, under this Agreement. 
 5.5 Manufacturing Records. Agila shall
generate and maintain complete and accurate records and samples as necessary to evidence compliance with this Agreement and all Applicable Laws and other requirements of applicable governmental authorities relating to the manufacture of each
Collaboration Product, including validation data, stability testing data, certificates of analysis, certificates of origin of all raw materials, batch and lot records, quality 

  
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control and laboratory testing, and any other data required by Applicable Laws. All such records and samples shall be maintained for such periods as may be required by Applicable Law. Upon
request by Pfenex, Agila shall provide Pfenex (or its designee) reasonable access to, and copies and portions of, such records and samples, including all batch and lot records, and any supporting data relating thereto, including written
investigations of any deviations that may have been generated from manufacturing, packaging, inspection, or testing processes. 
 5.6
Inspection. During the Term and such longer period required by Applicable Laws, upon at least ten (10) business days advance notice and at reasonable frequency, Pfenex shall have the right to inspect and audit, during regular business
hours: (a) any Facility or any other location at which any of the manufacturing, processing or other activities relating to any Collaboration Product are performed hereunder; and (b) any of the manufacturing and quality control records and
all other documentation relating to the manufacturing, processing and other activities with respect to any Collaboration Product (including any internal quality control audits or reviews. Such inspections and audits shall be for the purpose of
ascertaining compliance with Applicable Laws, the Specifications and other aspects of this Agreement, reviewing correspondence, reports, filings and other documents from or to Regulatory Authorities to the extent related to the manufacturing,
processing and other activities hereunder, approving, where appropriate, all variances from applicable requirements hereunder, and evaluating the implementation of all manufacturing and process changes pursuant to this Agreement. In performing any
such audit or inspection, employees or consultants of Pfenex shall: (i) not unreasonably interfere with other activities of Agila being carried out at the location at which such audit or inspection is taking place; and (ii) observe all
rules and regulations applicable to visitors and to individuals employed at the Facility which have been communicated by Agila to Pfenex in writing. Any information obtained by Pfenex through such inspections and audits shall be treated as
Confidential Information of Agila in accordance with Article 9 below. 
 5.7 [*] Facility. Agila will use all reasonable efforts to
ensure that all applicable testing and validation of the [*] Facility has been successfully completed, and all required Consents have been obtained, and such facility is otherwise ready and available for use in manufacture of each Collaboration
Product as soon as practicable and in no event later than the earlier of (i) the time Agila or the JVC, as applicable, receives a manufacturing license for the applicable Collaboration Product from the applicable Regulatory Authority and
(ii) the JVC is otherwise prepared to commercially launch such Collaboration Product. In the event that the [*] Facility is not so completed for commercial production, Agila shall make alternative arrangements to supply the Collaboration
Product(s) to the JVC for commercialization under the terms and conditions set in the JVA. 
 Article 6 

REGULATORY MATTERS 

6.1 General. As between the Parties, Agila shall be solely responsible for Regulatory Filings, obtaining and maintaining all necessary
Regulatory Approvals for the initiation and performance of the first Phase I Clinical Trial for each Collaboration Product; provided that all such activities shall be performed in a manner that is consistent with the applicable Development Plan
developed in accordance with Section 3.1. As between the Parties, Agila shall assume all responsibilities of sponsors and investigators under Applicable Laws for 

  
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the first Phase I Clinical Trial for each Collaboration Product. Upon the transfer of any Collaboration Product to the JVC as provided in Section 3.9, Agila shall assign and deliver, or
cause to be assigned and delivered, to the JVC, and the JVC shall assume control of, all Regulatory Filings and approvals (including Regulatory Approvals) and all communications with the applicable Regulatory Authorities with respect thereto
obtained and maintained by Agila or its Affiliate in connection with the development of such Collaboration Product(s). 
 6.2 Meetings
with Regulatory Authorities. Agila shall timely inform Pfenex as soon as reasonably practicable of any meetings scheduled with any Regulatory Authority concerning any Collaboration Product. As reasonably requested in a timely manner, Agila shall
allow representatives from Pfenex to participate in such meetings with any Regulatory Authority. 
 6.3 Regulatory Filings.
Reasonably in advance of the submission of any Regulatory Filing or material correspondence with applicable Regulatory Authorities for any Collaboration Product, Agila shall provide a copy of such document to Pfenex for its review and shall
incorporate any reasonable comments and suggestions provided by Pfenex with respect thereto. Agila shall make available, directly, or through the JSC, copies of any Regulatory Filing or correspondence with applicable Regulatory Authorities for any
Collaboration Product promptly after such Regulatory Filing or correspondence has been submitted to the applicable Regulatory Authority. 

6.4 Regulatory Actions. Agila shall permit all applicable Regulatory Authorities to conduct such inspections of the Facility or any
other location at which any of the manufacturing or development activities (including pre-clinical or clinical studies) relating to any Collaboration Product are performed, as such Regulatory Authorities may request in accordance with Applicable
Laws and shall cooperate with such Regulatory Authorities with respect to such inspections and any related matters. Agila shall give Pfenex prompt written notice of any such inspections, and shall keep Pfenex informed about the results and
conclusions of each such regulatory inspection, including actions taken by Agila to remedy conditions cited in such inspections. In addition, Agila shall allow Pfenex or its representative to assist in the preparation for and be present at such
inspections for which it has advanced notice. Agila shall provide Pfenex with copies of any written inspection reports issued by any Regulatory Authority and all correspondence between Agila and any Regulatory Authority with respect thereto.
Additionally, Agila agrees to promptly notify and provide Pfenex copies of any request, directive or other communication of the applicable Regulatory Authority relating to or otherwise that may affect any Collaboration Product or its manufacture or
development. Prior to responding to any reports, requests, directive or other communications issued by any Regulatory Authority relating to or otherwise that may affect any Collaboration Product or its manufacture or development, Agila shall provide
Pfenex a copy of its proposed response for Pfenex’s review and comments and Agila shall include any reasonable comments or recommendations provided by Pfenex with respect thereto prior to submitting such response to the applicable Regulatory
Authority. Agila shall provide Pfenex a copy of its final response contemporaneously with submitting the response to the Regulatory Authority. 

  
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 Article 7 

RECORDS; INSPECTIONS 

7.1 Record Keeping. Without limiting any other specific record-keeping obligations set forth in this Agreement or any Development Plan,
each Party shall generate and maintain, during the Term and such longer period required by Applicable Laws, complete and accurate records related to its performance of its obligations under each Development Plan as necessary to evidence compliance
with this Agreement and all Applicable Laws. Upon the transfer of any Collaboration Product to the JVC as provided in Section 3.9, each Party shall deliver, or cause to be delivered, to the JVC all records (or copies thereof) kept by such Party
in accordance with this Section 7.1. 
 7.2 Inspection. Without limiting any other specific inspection provisions in this
Agreement or any Development Plan, during the Term and such longer period required by Applicable Laws, at least ten (10) business days advance notice by a Party and at reasonable frequency, such Party shall have the right to inspect and audit,
during regular business hours, the records kept by the other Party pursuant to Section 7.1. Such inspections and audits shall be for the purpose of ascertaining compliance with this Agreement and Applicable Laws. Any information obtained by the
auditing Party through such inspections and audits shall be treated as Confidential Information of the audited Party in accordance with Article 9 below. 

Article 8 
 DILIGENCE

 8.1 Diligence. Each Party will expend, with respect to each objective set forth in this Agreement or otherwise assigned to
such Party under any Development Plan, its reasonable, good faith efforts to accomplish such objective consistent with those efforts it normally expends to accomplish a similar objective under similar circumstances. It is understood and agreed that
with respect to any Collaboration Product(s), each Party’s efforts will be substantially equivalent to those efforts and resources commonly used for pharmaceutical products owned by it or to which it has rights, which product is at a similar
stage in its development or product life and is of similar market potential as such Collaboration Product taking into account all relevant factors. Without limiting the foregoing, each Party shall achieve the applicable milestones set forth in
Exhibit 1 attached hereto (each, a “Milestone”) with respect to activities assigned to it under this Agreement or the applicable Development Plan within the corresponding timelines set forth in Exhibit 1. For
clarity, the date by which the Development Plan for each Collaboration Product shall be executed by the Parties shall each be a Milestone, and a failure to meet such Milestone with respect to a Collaboration Product shall trigger the termination
right set forth in Section 3.1 with respect to such Collaboration Product. 
 Article 9 

CONFIDENTIALITY 

9.1 Confidential Information. The Parties may from time to time disclose to each other Confidential Information. “Confidential
Information” means any information disclosed by one Party to the other Party hereto, which (i) if disclosed in tangible form is marked “confidential” or with other similar designation to indicate its confidential or
proprietary nature, 

  
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(ii) if disclosed orally, is identified as confidential or proprietary by the Party disclosing such information at the time of its initial disclosure and is confirmed in writing as
confidential or proprietary by the disclosing Party within forty five (45) days after such initial disclosure, or (iii) is reasonably expected to be treated in a confidential manner based on the nature of such information and the
circumstances of its disclosure. For clarity, the terms of this Agreement and all Study Results shall be deemed Confidential Information of both Parties. Notwithstanding the foregoing or anything herein to the contrary, a receiving Party’s
obligations under this Article 9 shall not apply to any information that, in each case as demonstrated by written documentation: (a) was already known to the receiving Party, other than under an obligation of confidentiality, at the time of
disclosure; (b) was generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving Party; (c) became generally available to the public or otherwise part of the public domain after
its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement; (d) was subsequently lawfully disclosed to the receiving Party by a Person other than the disclosing Party; or (e) was
independently developed by the receiving Party without use of or reference to any Confidential Information of the disclosing Party. 
 9.2
Confidentiality. During the Term of this Agreement and for five (5) years thereafter without regard to the means of termination (or if the JVA is entered into, then such longer period as required by the JVA), neither Party shall use, for
any purpose other than the purpose of this Agreement including (i) in connection with the performance of its obligations or exercise of rights granted to such Party in this Agreement and (ii) to the extent such disclosure is reasonably
necessary in filing for, prosecuting or maintenance of patents and other intellectual property rights (including applications therefor) in accordance with this Agreement, prosecuting or defending litigation, complying with applicable governmental
regulations, filing for, conducting preclinical or clinical trials, obtaining and maintaining regulatory approvals, or otherwise required by Applicable Laws or the rules of a recognized stock exchange, reveal or disclose to any Third Party other
than consistent with such use including to potential investors, acquirers, investment bankers, lenders or their respective advisors and attorneys, Confidential Information and materials disclosed by the other Party (whether prior to or during the
Term of this Agreement) without first obtaining the written consent of the other Party. The Parties agree to take all necessary steps to ensure that Confidential Information is securely maintained and to inform those who are authorized to receive
such Confidential Information of their obligations under this Agreement and subject to written non-disclosure, non-use requirements consistent with this Article 9. Upon the termination or expiration of this Agreement for any reason (unless the JVA
is entered into, then as required in the JVA), the receiving Party promptly shall, upon request by the disclosing Party, return all such Confidential Information, and any copies or reproductions thereof, to the disclosing Party and agrees to make no
further use of such Confidential Information, except it may retain one copy thereof solely for use in complying with any record keeping and other obligations within such Party’s jurisdiction. 

9.3 Reasonable Precautions. The Parties shall take all reasonable precautions to prevent the use or disclosure of such Confidential
Information of the other Party without first obtaining the written consent of the other Party, except in accordance with Section 9.2 which may require disclosure to a governmental authority, regulatory authority, pricing authority in the
Territory or otherwise required to be disclosed for diligence exercise for any transaction in connection with the development of any Collaboration Product in accordance herewith which may involve any Third Party, government authority, customer,
bank, fund raising institution subject to written non-disclosure, non-use requirements consistent with this Article 9. 

  
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 9.4 Publicity Review. 

9.4.1 Press Releases and Public Announcements. Neither Party shall issue any press release or other publicity materials, or make any
public presentation with respect to this Agreement, the terms or conditions of this Agreement, or any Collaboration Product including with respect to any Study Results without the prior written consent of the other Party (such consent not to be
unreasonably withheld, conditioned or delayed). The restrictions provided in this Section 9.4.1 shall not apply to disclosures required by Applicable Law, including as may be required in connection with any filings made with the Securities and
Exchange Commission or similar non-U.S. regulatory authority, or by the disclosure policies of a major stock exchange; provided that each Party shall use good faith efforts to provide any such disclosure at least five (5) business days prior to
such disclosure (to the extent practicable) for the other Party’s review and comment. 
 9.4.2 Use of Names. Neither Party
shall utilize the name or trademarks of the other Party or make any disclosures concerning this Agreement, without the other Party’s prior written consent, provided that such use or disclosure shall be permitted if required by Applicable Laws
and the Party making such use or disclosure consults with the other Party to the extent practicable not less than thirty (30) days prior the use or disclosure. 

9.5 Prior Agreement. This Agreement supersedes the terms and conditions of the Confidentiality Agreement between the Parties dated
May 2, 2012 (“Prior Confidentiality Agreement”) with respect to information disclosed thereunder. All information exchanged between the Parties under such Prior Confidentiality Agreement shall be deemed Confidential Information
of the disclosing Party and shall be subject to the terms of this Article 9. 
 Article 10 

INTELLECTUAL PROPERTY 

10.1 Background Technology. Except for the limited licenses granted under Section 10.2 below, as between the Parties, each Party
retains full right, title and interest in and to its Background Technology. Unless otherwise expressly set forth in this Agreement, each Party shall be fully responsible for obtaining and maintaining, at its own expense, ownership of or appropriate
license to any technologies (and intellectual property rights therein) that are necessary for its performance of its obligations under each Development Plan. Without limiting the generality of the foregoing, Agila shall be solely responsible for
developing or acquiring (including licensing or acquiring rights or assets from any Third Party), subject to the oversight and consent of the JSC, any PEGylation technology that is necessary for the development of PEGylated Interferon beta-1B,
PEGylated Granulocyte Colony-Stimulating Factor, PEGylated L-Asparaginase and any additional PEGylated Collaboration Products as further provided in the applicable Development Plan. Agila shall be responsible for all costs associated with the
development or acquisition of any such PEGylation technologies, except for any royalty payable to a Third Party upon the sale of any Collaboration Product(s) in which such PEGylation technologies are incorporated, which royalty will be borne by the
JVC. 

  
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 10.2 License Grant 

10.2.1 License to Agila. Pfenex hereby grants to Agila a non-exclusive, worldwide, fully-paid up, royalty-free license under
Pfenex’s Background Technology and any Collaboration Technology solely owned by Pfenex pursuant to this Article 10, together with all intellectual property rights therein, solely to the extent necessary for Agila to perform the activities
allocated to it under this Agreement and the applicable Development Plan during the Term. 
 10.2.2 License to Pfenex. Agila hereby
grants to Pfenex a non-exclusive, worldwide, fully-paid up, royalty-free license under Agila’s Background Technology and any Collaboration Technology solely owned by Agila pursuant to this Article 10, together with all intellectual property
rights therein, solely to the extent necessary for Pfenex to perform the activities allocated to it under this Agreement and the applicable Development Plan during the Term. 

10.2.3 No Other Right. All rights and licenses granted under this Agreement are limited to the scope expressly granted. Accordingly,
except for the rights expressly granted under this Agreement, no right, title, or interest of any nature whatsoever is granted whether by implication, estoppel, reliance, or otherwise, by either Party to the other Party. 

10.3 Collaboration Technology. Except as provided in Sections 10.4 and 10.5 and subject to Section 10.6, as between the
Parties all right, title and interest to inventions and other subject matter (together with all intellectual property rights therein) conceived or created or first reduced to practice in connection with the exercise of rights or performance of
obligations under this Agreement (collectively, “Collaboration Technology”) (i) by or under the authority of Pfenex or its Affiliates, independently of Agila and its Affiliates, shall be owned by Pfenex, (ii) by or under
the authority of Agila or its Affiliates, independently of Pfenex and its Affiliates, shall be owned by Agila, and (iii) by personnel of Pfenex or its Affiliates and Agila or its Affiliates shall be jointly owned by Pfenex and Agila. Except as
expressly provided otherwise in this Agreement, neither Party shall have any obligation to obtain any approval of the other Party for, nor pay the other Party any share of the proceeds from or otherwise account to the other Party for, the practice,
enforcement, licensing, assignment or other exploitation of such jointly owned Collaboration Technology, and each Party hereby waives any right it may have under the Applicable Laws of any country to require such approval, sharing or accounting.
Except as otherwise expressly provided hereunder, the Party that owns any particular Collaboration Technology shall, as between the Parties, have the sole and exclusive right to control the filing for, prosecution, maintenance and enforcement of any
intellectual property rights therein in its sole discretion and any jointly owned Collaboration Technology will be prosecuted, maintained and enforced as determined by the intellectual property Subcommittee in accordance with the procedures set
forth in Section 2.7. 
 10.4 Pfenex Improvements. Notwithstanding Section 10.3 above, all Pfenex Improvements will be the
sole and exclusive property of Pfenex, and Agila hereby assigns to Pfenex all Pfenex Improvements. Agila will promptly disclose to Pfenex any and all Pfenex Improvements and take such other reasonable actions at Pfenex’s request and expense to

  
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effectuate such assignment. As used herein, “Pfenex Improvements” means: all modifications and improvements to any Pfenex Expression Technology or Pfenex Materials and
Deliverables and all inventions claiming the use of Pfenex Expression Technology that are not solely applicable to any Collaboration Product, together with all intellectual property rights pertaining to the foregoing. 

10.5 Agila Improvements. Notwithstanding Section 10.3 above, all Agila Improvements will be the sole and exclusive property of
Agila. As used herein, “Agila Improvements” means all modifications and improvements to any Agila’s proprietary manufacturing and/or formulation technologies that are not (a) solely applicable to any Collaboration Product
or (b) based upon or include any Pfenex Expression Technology, Pfenex Materials and Deliverables or Confidential Information of Pfenex, together with intellectual property rights pertaining to the foregoing. 

10.6 Assignment to JVC. Upon the transfer of any Collaboration Product to the JVC as provided in Section 3.9, each Party shall
assign, or cause to be assigned, to the JVC, all of its right, title and interest in and to any Collaboration Technology (excluding any Pfenex Improvement) arising from the performance of the applicable Development Plan and the JVC shall have the
sole and exclusive right to control the filing for, prosecution, maintenance and enforcement of any intellectual property rights in such Collaboration Technology in its sole discretion. Each Party shall grant to the JVC appropriate licenses to its
Background Technology to enable the JVC to further develop and commercialize the applicable Collaboration Product. 
 10.7 Disclosure and
Cooperation. Each Party shall promptly disclose to the other Party any Collaboration Technology generated hereunder. The Parties shall at all times fully cooperate in order to reasonably implement the provisions of this Article 10. Such
cooperation may include the execution of necessary legal documents, coordinating prosecution to avoid or mitigate any patentability issues, and the provision of any other assistance reasonably requested by the other Party at such other Party’s
expenses. 
 Article 11 

TERM AND TERMINATION 

11.1 Term. The term of this Agreement shall commence on the Effective Date and shall continue on a Collaboration
Product-by-Collaboration Product basis until the Successful Completion of the first Phase I Clinical Trial for the applicable Collaboration Product (“Term”). For clarity, prior to each Party signing the applicable Development Plan
for a particular Collaboration Product hereunder as set forth in Section 3.1, neither Party shall have any rights or obligations hereunder with respect to such product, except that the Parties will use good faith efforts to prepare and agree on
Development Plan in accordance with Section 3.1 for each product described in Section 1.6(a) – (e) unless either Party prior to the signing of the Development Plan for such product provides sixty (60) days’ prior
written notice to the other Party that it desires to exclude such product herefrom, in which case, such product shall be excluded; provided that if the other Party desires the Parties shall discuss the basis for such exclusion during such sixty
(60) day period. 

  
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 11.2 Termination for Material Breach. If either Party materially breaches this Agreement,
the non-breaching Party shall have the right to terminate this Agreement, in its entirety or with respect to any Collaboration Product that is subject to the applicable Development Plan under which such material breach occurs, by written notice to
the breaching Party specifying the breach and referencing this Section 11.2, if such breach is not cured within ninety (90) days after written notice is given by the non-breaching Party to the breaching Party specifying the breach;
provided, however, that in the event of a good faith dispute with respect to the existence of a material breach, this Agreement or the applicable Development Plan shall not be terminated unless it is finally determined pursuant to Section 14.10
such material breach has occurred, and the breaching party fails to cure such breach within ninety (90) days after such determination. 

11.3 Termination for Insolvency. Each Party shall have the right to terminate this Agreement upon delivery of written notice to the
other Party in the event that (i) such other Party files in any court or agency pursuant to any statute or regulation of any jurisdiction a petition in bankruptcy or insolvency or for reorganization or similar arrangement for the benefit of
creditors or for the appointment of a receiver or trustee of such other Party or its assets, (ii) such other Party is served with an involuntary petition against it in any insolvency proceeding and such involuntary petition has not been stayed
or dismissed within ninety (90) days of its filing, or (iii) such other Party makes an assignment of substantially all of its assets for the benefit of its creditors. 

11.4 Termination for Failure to Enter into the JVA. In the event the Parties fail to enter into the JVA pursuant to Section 3.8 by
February 28, 2013, this Agreement shall terminate automatically unless otherwise mutually agreed by the Parties in writing. 
 11.5
Cross Termination with the JVA. In the event the JVA is terminated in its entirety in accordance with its terms, this Agreement shall terminate automatically unless otherwise mutually agreed by the Parties in writing. 

11.6 Effects of Termination. 

11.6.1 Expiration or termination of this Agreement (in its entirety or with respect to any Collaboration Product) for any reason shall not
release either Party of any obligation or liability which, at the time of such expiration or termination, has already accrued to such Party or which is attributable to a period prior to such expiration or termination. 

11.6.2 Upon expiration or termination of this Agreement (in its entirety or with respect to any Collaboration Product), all rights and
licenses to any technology and intellectual property rights therein granted by either Party to the other Party under this Agreement or with respect to the applicable terminated Collaboration Product, as applicable, shall terminate and revert back to
the Party granting such rights or licenses. 
 11.6.3 Upon termination of this Agreement or with respect to any Collaboration Product(s),
each Party shall cease all work under this Agreement or the applicable Development Plan, as applicable, except for activities as necessary for an orderly wind-down of the performance of this Agreement or the applicable Development Plan, and return
to the other 

  
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Party all Confidential Information of the other Party and unused materials provided to it by the other Party under this Agreement or the applicable Development Plan, as applicable, and all copies
and embodiments thereof, except that each Party may retain one copy of the other Party’s written Confidential Information in its confidential files solely for archival purposes. Without limiting the generality of the foregoing, upon termination
of this Agreement (in its entirety or with respect to any Collaboration Product), Agila shall immediately cease any use or practice of Pfenex Materials and Deliverables provided under this Agreement or under the applicable Development Plan, as
applicable, and return all remaining Pfenex Materials and Deliverables in Agila’s possession, including all embodiments or derivatives thereof. 

11.6.4 Upon expiration of this Agreement with respect to any Collaboration Product(s), in the event such Collaboration Product(s) is
transferred to the JVC as provided in Section 3.9, each Party shall fully cooperate with each other to facilitate a smooth, orderly and prompt transfer of such Collaboration Product(s) to the JVC. Without limiting the generality of the
foregoing, (i) Agila shall assign or cause to be assigned to the JVC all Regulatory Filings and Regulatory Approvals and all communications with the applicable Regulatory Authorities obtained or maintained by or on behalf of Agila under this
Agreement with respect to such Collaboration Product(s), (ii) each Party shall assign all of its right, title and interest in and to any Collaboration Technology (excluding Pfenex Improvements) to the JVC, and (iii) each Party shall
transfer to the JVC all records, reports and other work products generated during its performance of the applicable Development Plan. 

11.6.5 Upon expiration of this Agreement with respect to any Collaboration Product, in the event such Collaboration Product(s) is not
transferred to the JVC as provided in Section 3.9, unless otherwise mutually agreed by the Parties, each Party shall return to the other Party all Confidential Information of the other Party and unused materials provided to it by the other
Party (including Pfenex Materials and Deliverables provided to Agila) under this Agreement or the applicable Development Plan, as applicable, and all copies and embodiments thereof, except that each Party may retain one copy of the other
Party’s written Confidential Information in its confidential files solely for archival purposes. Upon expiration of this Agreement with respect to any Collaboration Product, in the event such Collaboration Product(s) is not transferred to the
JVC as provided in Section 3.9, if Pfenex elects to continue the development of such Collaboration Product, the Parties shall discuss in good faith terms and conditions that are reasonable and customary in the pharmaceutical industry pursuant
to which Agila will transfer all Regulatory Approvals obtained or maintained by or on behalf of Agila under this Agreement with respect to such Collaboration Product (together with all relevant Regulatory Filings and correspondence with Regulatory
Authorities) and granting Pfenex a license to all technologies and associated intellectual property rights owned or controlled by Agila that are necessary or useful for the development and commercialization of such Collaboration Product. 

11.7 Survival. The provisions of Articles 1, 7, 9, 13 and 14, and Sections 4.3, 5.5, 5.6, 5.7, 10.1, 10.2.3, 10.3-10.7, 11.6,
11.7, 12.2 (last sentence) and 12.3 shall survive the termination of this Agreement for any reason. All other rights and obligations of the Parties shall cease upon termination of this Agreement. Except as otherwise expressly provided in this
Section 11.7, all other rights and obligations of the Parties shall terminate. 

  
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 Article 12 

REPRESENTATIONS AND WARRANTIES 

12.1 Mutual Representations and Warranties. Each Party represents and warrants to the other Party that: (a) as of the Effective
Date, it has the power and authority to enter into this Agreement and to perform its obligations hereunder and to grant to the other Party the rights granted to such other Party under this Agreement; (b) as of the Effective Date, it has
obtained all necessary corporate and other approvals to enter into and execute this Agreement; and (c) it is not, as of the Effective Date, a party to, nor will it enter into or assume during the Term, any contract or other obligation with a
Third Party that would in any way limit the performance of its obligations under this Agreement (d) this Agreement will, when executed, constitute valid and binding obligations on the Parties; and (e) entry into and performance by it of
this Agreement will not (i) breach any provision of its bylaws or equivalent constitutional documents; or (ii) result in a breach of any Applicable Laws in its jurisdiction of incorporation or of any order, decree or judgment of any court
or any Regulatory Authority, where any such breach would affect to a material extent its ability to enter into or perform its obligations under this Agreement. 

12.2 No Debarment. Each Party further represents and warrants that neither it, nor any of its Affiliates, nor any of their respective
employees or contractors involved in the performance of this Agreement have been “debarred” by the FDA pursuant to 21 U.S.C. § 335a or subject to a similar sanction from any Regulatory Authority in any other jurisdiction, nor
have debarment or similar proceedings against such Party, any of its Affiliates, or any of their respective employees or contractors involved in the performance of this Agreement been commenced. Each Party will promptly notify the other Party in
writing if any such proceedings are commenced or if such Party, any of its Affiliates, or any of their respective employees or contractors involved in the performance of this Agreement are debarred or similarly sanctioned by any Regulatory
Authority. 
 12.3 DISCLAIMERS. 

12.3.1 GENERAL. EXCEPT AS EXPRESSLY PROVIDED IN THIS AGREEMENT, NEITHER PARTY MAKES ANY WARRANTIES (EXPRESS, IMPLIED, STATUTORY OR
OTHERWISE) WITH RESPECT TO THE SUBJECT MATTER HEREOF AND EACH PARTY EXPRESSLY DISCLAIMS ANY SUCH ADDITIONAL WARRANTIES, INCLUDING ANY IMPLIED WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE, MERCHANTABILITY OR NONINFRINGEMENT OF INTELLECTUAL PROPERTY
RIGHTS. 
 12.3.2 PFENEX MATERIALS AND DELIVERABLES. EXCEPT AS PROVIDED IN SECTION 4.2, THE PFENEX MATERIALS AND DELIVERABLES ARE
PROVIDED “AS-IS.” 
 12.4 LIMITATION OF LIABILITY. NEITHER PARTY WILL BE LIABLE TO THE OTHER PARTY FOR INDIRECT,
INCIDENTAL, CONSEQUENTIAL, OR SPECIAL DAMAGES INCLUDING, BUT NOT LIMITED TO LOST PROFITS ARISING FROM OR RELATING TO THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE 

  
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POSSIBILITY OF SUCH DAMAGES. HOWEVER, NOTHING IN THIS SECTION IS INTENDED TO LIMIT OR RESTRICT THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF EITHER PARTY UNDER ARTICLE13. 

Article 13 
 INDEMNIFICATION

 13.1 Pfenex. Pfenex shall indemnify, defend and hold harmless Agila, its directors, officers, employees, agents,
successors and assigns from and against any liabilities, expenses or costs (including reasonable attorneys’ fees and court costs) arising out of any claim, complaint, suit, proceeding or cause of action against any of them by a Third Party
resulting from: (a) the negligent or intentionally wrongful acts or omissions of Pfenex, its Affiliates and subcontractors during the performance of any Development Plan or (b) any breach by Pfenex of its representations and warranties
under this Agreement; in each case, subject to the requirements set forth in Section 13.3 below. Notwithstanding the foregoing, Pfenex shall have no obligations under this Article 13 for any liabilities, expenses or costs arising out of or
relating to claims to the extent covered under Section 13.2 below. 
 13.2 Agila. Agila shall indemnify, defend and hold
harmless Pfenex, its directors, officers, employees, agents, successors and assigns from and against all liabilities, expenses, and costs (including reasonable attorneys’ fees and court costs) arising out of any claim, complaint, suit,
proceeding or cause of action against any of them by a Third Party resulting from: (a) the negligent or intentionally wrongful acts or omissions of Agila, its Affiliates and subcontractors during the performance of any Development Plan or
(b) any breach by Agila of any of its representations and warranties under this Agreement; in each case, subject to the requirements set forth in Section 13.3 below. Notwithstanding the foregoing, Agila shall have no obligations under this
Article 13 for any liabilities, expenses or costs arising out of or relating to claims to the extent covered under Section 13.1 above. 

13.3 Indemnification Procedure. Any Party seeking indemnification under this Article 13 (the “Indemnitee”) shall:
(a) promptly notify the indemnifying Party (the “Indemnitor”) of such claim; (b) provide the Indemnitor sole control over the defense or settlement thereof; and (c) at the Indemnitor’s request and expense,
provide full information and reasonable assistance to Indemnitor with respect to such claims. Without limiting the foregoing, with respect to claims brought under Section 13.1 or 13.2 above the Indemnitee, at its own expense, shall have the
right to participate with counsel of its own choosing in the defense or settlement of any such claim. The indemnification under this Article 13 shall not apply to amounts paid in settlement of any claim if such settlement is effected without the
consent of the Indemnitor. 
 13.4 Insurance. Each Party will procure and maintain, at its own expense, insurance, with a financially
sound and reputable insurer, reasonably sufficient to cover such Party’s activities and its obligations under this Agreement with minimum coverage amounts customary for the activities of such Party hereunder in the jurisdiction(s) where such
activities are performed or such other minimums as the JSC may establish. Without limiting the foregoing, Agila shall procure and maintain clinical trial insurance with minimum coverage amounts customary for Phase I Clinical Trials in the
jurisdiction(s) where such clinical studies 

  
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are performed or such other minimums as the JSC may establish. Each Party will furnish at the request of the other Party a certificate(s) reflecting relevant insurance coverage and limits. Each
Party will name the other as an additional insured on the policies for the coverage required herein. 
 Article 14 

GENERAL PROVISIONS 

14.1 Affiliates. Each Party may perform any obligations and exercise any rights hereunder through any of its Affiliates. Each Party
hereby guarantees the performance by its Affiliates of such Party’s obligations under this Agreement, and will cause its Affiliates to comply with the provisions of this Agreement in connection with such performance. Any breach by a
Party’s Affiliate of any of such Party’s obligations under this Agreement will be deemed a breach by such Party, and the other Party may proceed directly against such Party without any obligation to first proceed against such Party’s
Affiliate. 
 14.2 Assignment. Each Party agrees that its rights and obligations under this Agreement may not be assigned or
otherwise transferred to a Third Party without the prior written consent of the other Party hereto. Notwithstanding the foregoing, either Party may transfer or assign its rights and obligations under this Agreement to (a) an Affiliate, subject
to the prior notice to the other Party and the assigning Party remaining responsible for such Affiliate’s performance or (b) a successor to all or substantially all of its business or assets relating to this Agreement whether by sale,
merger, operation of law or otherwise, without the prior written consent of the other Party; provided that such assignee or transferee has agreed to be bound by the terms and conditions of this Agreement. Subject to the foregoing, this Agreement
shall be binding upon and inure to the benefit of the Parties hereto, their successors and assigns. 
 14.3 Severability. If any
clause, provision, or Section of this Agreement attached hereto, shall, for any reason, be held illegal, invalid or unenforceable, the Parties shall negotiate in good faith and in accordance with reasonable standards of fair dealing, a valid,
legal, and enforceable substitute provision or provisions that most nearly reflect the original intent of the Parties under this Agreement in a manner that is commensurate in magnitude and degree with the changes arising as a result of any such
substitute provision or provisions. All other provisions in this Agreement shall remain in full force and effect and shall be construed in order to carry out the original intent of the Parties as ‘nearly as possible (consistent with the
necessary reallocation of benefits) and as if such invalid, illegal, or unenforceable provision had never been contained herein. 
 14.4
Merger of Understandings; Amendment. This Agreement (and the Exhibits attached hereto and Purchase Orders issued pursuant hereto) and the Quality Agreement constitute the entire agreement between the Parties regarding the subject matter
hereof and all prior negotiations and understandings between the Parties are deemed to be merged into this Agreement. No agreement or understanding varying or extending this Agreement shall be binding upon either Party hereto, unless set forth in a
writing which specifically refers to the Agreement signed by duly authorized officers or representatives of the respective Parties, and the provisions hereof not specifically amended thereby shall remain in full force and effect. 

  
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 14.5 Waiver. Any waiver of the terms and conditions hereof must be explicitly in writing
and executed by a duly authorized officer of the Party waiving compliance. The waiver by either of the Parties of any breach of any provision hereof by the other shall not be construed to be a waiver of any succeeding breach of such provision or a
waiver of the provision itself. The delay or failure of any Party at any time to require performance of any provision of this Agreement shall in no manner affect such Party’s rights at a later time to enforce the same. 

14.6 Notices. Any notice, report or other communication required or permitted to be given by either Party under this Agreement shall be
given in writing and may be delivered by hand, reputable international 3- or 4-day courier service or by mailing if mailed by registered or certified mail, postage prepaid and return receipt requested (or the international equivalent), or by email
or fax (with printed confirmation of transmission and with confirmation copy forwarded by reputable international 3- or 4-day courier service), addressed to each Party as follows. Such information may be updated by a Party upon written notice to the
other Party. A notice shall be deemed delivered upon receipt, unless the notice is received on a day other than a business day in the jurisdiction of the recipient or after 5:30 p.m. at the location of delivery, in which case delivery shall be
deemed to be the next business day after receipt (as determined in the jurisdiction of recipient). 
  

			
	For Pfenex:	  	Pfenex Inc.
		  	10790 Roselle Street
		  	San Diego, CA 92121
		  	Attn: Patrick Lucy
		  	Fax: +1 978 887-4972
		  	Email: PKL@Pfenex.com
		
	For Agila:	  	Agila Biotech Private Limited
		  	Strides House, Bilekahalli
		  	Bannergahtta Road,
		  	Bangalore 560 076, INDIA
		  	Attention: Legal Department
		  	Fax: + 91 80 6784 0700 / 800
		  	Email: legal@stridesarco.com

 14.7 Force Majeure. Neither of the Parties shall be liable for any default or delay in performance of
any obligation under this Agreement caused by any of the following: Act of God, war, terrorism, riot, fire, explosion, accident, flood, sabotage, compliance with governmental requests, laws, regulations, orders or actions, national defense
requirements or any other event beyond the reasonable control of such Party, or labor trouble, strike, lockout or injunction (provided that neither of the Parties shall be required to settle a labor dispute against its own best judgment). The Party
invoking the provisions of this Section14.7 shall give the other Party written notice and full particulars of such force majeure event. Both Pfenex and Agila shall use reasonable business efforts to mitigate the effects of any force majeure on their
respective part. 
 14.8 Relationship of the Parties. The relationship of Pfenex and Agila is strictly one of independent contractors
and the Parties acknowledge that this Agreement does not 

  
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create a joint venture, partnership, or the like, between them. Pfenex and Agila shall always remain independent contractors in its performance of this Agreement. Neither Party shall have any
authority to employ any individual as an employee or agent for or on behalf of the other Party to this Agreement for any purpose, and neither Party, nor any person performing any duties or engaging in any work at the request of such Party, shall be
deemed to be an employee or agent of the other Party. 
 14.9 Choice of Law. All questions with respect to the construction of this
Agreement and the rights and liabilities of the Parties hereto shall be determined in accordance with the laws of England and Wales, without regard to any provisions of conflicts of law and shall not be governed by the United Nations Convention on
Contracts for the International Sale of Goods. 
 14.10 Dispute Resolution. 

14.10.1 General. If the Parties are unable to resolve any dispute or other matter arising out of or in connection with this Agreement,
either Party may, by written notice to the other, have such dispute referred to the Chief Executive Officers of Parties for attempted resolution by good faith negotiations promptly after such notice is received. In such event, each Party shall cause
its Chief Executive Officers to meet (face-to-face or by teleconference) and be available to attempt to resolve such issue. If the Parties should resolve such dispute or claim, a memorandum setting forth their agreement will be prepared and signed
by both Parties if requested by either Party. The Parties shall cooperate in an effort to limit the issues for consideration in such manner as narrowly as reasonably practicable in order to resolve the dispute. 

14.10.2 Arbitration. In the event that the Parties are unable to resolve any such matter subject to Section 14.10.1 within sixty
(60) days from the date such dispute was referred to the Chief Executive Officers of the Parties, then either Party may initiate arbitration pursuant to this Section 14.10.2. Any arbitration under this Section 14.10.2 shall be
conducted in English under the Arbitration Rules of the Singapore International Arbitration Centre (“SIAC”) in Singapore by a single arbitrator mutually selected by the Parties or otherwise selected in accordance with such rules. In
such arbitration, the arbitrator shall select an independent expert with significant experience relating to the subject matter of such dispute to advise the arbitrator with respect to the subject matter of the dispute. If the Parties are unable to
agree on an arbitrator, the arbitrator shall be selected by the chief executive of SIAC. The costs of such arbitration shall be shared equally by the Parties, and each Party shall bear its own expenses in connection with the arbitration. The parties
shall use good faith efforts to complete arbitration under this Section 14.10.2 within sixty (60) days following the initiation of such arbitration. The arbitrator shall establish reasonable additional procedures to facilitate and complete
such arbitration within such sixty (60) day period. Nothing in this Agreement shall limit the right of either Party to seek to obtain in any court of competent jurisdiction any equitable or interim relief or provisional remedy, including
injunctive relief. 
 14.11 Provisions Contrary to Law. In performing this Agreement, the Parties shall comply with all Applicable
Laws. Nothing in this Agreement shall be construed so as to require the violation of any law, and wherever there is any conflict between any provision of this Agreement and any law the law shall prevail, but in such event the affected provision of
this Agreement shall be affected only to the extent necessary to bring it within the Applicable Laws. 

  
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 14.12 Legal Fees. Except as otherwise provided herein, each Party shall bear its own legal
fees incurred in connection with the transactions contemplated hereby or the enforcement hereof. 
 14.13 Headings. Headings herein
are for convenience of reference only and shall in no way affect interpretation of this Agreement. 
 14.14 Counterparts. This
Agreement may be executed in any number of counterparts with the same effect as if all Parties had signed the same document. All such counterparts shall be deemed an original, shall be construed together and shall constitute one and the same
instrument. 
 14.15 Exhibits. The appended Exhibits and any modifications or amendments thereof form an integral part of this
Agreement. 
 [The remainder of this page left blank intentionally; signature page follows immediately behind] 

  
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 CONFIDENTIAL 

EXECUTION COPY 
 IN WITNESS WHEREOF,
the Parties hereto have caused their duly authorized representatives to execute this Agreement as of the Effective Date. 
  

									
	PFENEX INC.	 		 	AGILA BIOTECH PRIVATE LIMITED
					
	By:	 	 /s/ Bertrand C. Liang
	 		 	By:	 	 /s/ Anand Iyer

					
	Name:	 	 Bertrand C. Liang
	 		 	Name:	 	 Anand Iyer

					
	Title:	 	 CEO
	 		 	Title:	 	 CEO

 Exhibit 1 

Milestones and Timelines 

[*] 

  
 -2- 

 Exhibit 2 

Amounts to be reimbursed 
 Agila will
reimburse Pfenex for amounts incurred as of the Effective Date with respect to the conduct of activities for cGMP manufacturing, toxicology or any [*] for the Collaboration Product comprising [*] within thirty (30) days of receipt of invoice
therefor and other customary documentation. Without limiting the foregoing, the Parties will discuss how to address any other amounts due under the existing agreements with Syngene International Limited and Novotech (Australia) Pty Limited including
assigning such agreements to Agila. 
 [*] 

[*] 

  
 -3- 

 Exhibit 3 

Exceptions to Exclusivity 

[*] 

  
 -4-

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