Document:

EXHIBIT
      10.19

     

    Rosetta
      Genomics Ltd. 

     

    Global
      Share Incentive Plan (2006)

     

    1.    Name
      And Purpose.

     

    1.1    This
      plan, which has been adopted by the Board of Directors of the Company, Rosetta
      Genomics Ltd., as amended from time to time, shall be known as the Rosetta
      Genomics Ltd. Global Share Incentive Plan (2006) (the “Plan”).

     

    1.2    The
      purposes of the Plan are to attract and retain the best available personnel
      for
      positions of substantial responsibility, to provide additional incentive to
      Service Providers of the Company and its affiliates and subsidiaries, if any,
      and to promote the Company's business by providing such individuals with
      opportunities to receive Awards pursuant to the Plan and to strengthen the
      sense
      of common interest between such individuals and the Company's
      Shareholders.

     

    1.3    Awards
      granted under the Plan to Service Providers in various jurisdictions may be
      subject to specific terms and conditions for such grants may be set forth in
      one
      or more separate Appendix to the Plan, as may be approved by the Board of
      Directors of the Company from time to time.

     

    2.    Definitions

     

    “Administrator”
shall
      mean the Board of Directors or a Committee.

     

    "Affiliate"
      shall
      mean a company directly or indirectly controlled by, controlling or under common
      control with the Company, unless otherwise defined in an Appendix.

     

    “Appendix”
shall
      mean any appendix to the Plan adopted by the Board of Directors containing
      country-specific or other special terms relating to Awards including additional
      terms with respect to grants of restricted stock and/or other equity-based
      Awards.

     

    “Award”
shall
      mean a grant of Options or allotment of Shares or other equity based award
      hereunder. All Awards shall be confirmed by an Award Agreement, and subject
      to
      the terms and conditions of such Award Agreement. 

     

    “Award
      Agreement”
shall
      mean a written instrument setting forth the terms applicable to a particular
      Award. 

     

    “Board
      of Directors”
shall
      mean the board of directors of the Company.

     

    “Cause”
      shall
      have the meaning ascribed to such term or a similar term as set forth in the
      Participant's employment agreement or the agreement governing the provision
      of
      services by a non-employee Service Provider, or, in the absence of such a
      definition: (i)

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    conviction
      (or plea of nolo
      contendere)
      of any
      felony or crime involving moral turpitude or affecting the Company; (ii)
      repeated and unreasonable refusal to carry out a reasonable and lawful directive
      of the Company or of Participant’s supervisor which involves the business of the
      Company or its affiliates and was capable of being lawfully performed; (iii)
      fraud or embezzlement of funds of the Company or its affiliates; (iv) any breach
      by a director of his / her fiduciary duties or duties of care towards the
      Company; and (v) any disclosure of confidential information of the Company
      or
      breach of any obligation not to compete with the Company or not to violate
      a
      restrictive covenant.

     

    “Committee”
shall
      mean a compensation committee or other committee as may be appointed and
      maintained by the Board of Directors, in its discretion, to administer the
      Plan,
      to the extent permissible under applicable law, as amended from time to
      time.

     

    “Companies
      Law”
shall
      mean the Israeli Companies Law 5759-1999, as amended from time to
      time.

     

    “Company”
      shall
      mean Rosetta Genomics Ltd., an Israeli company, and its successors and
      assigns.

     

     “Consultant”
      means
      any entity or individual who (either directly or, in the case of an individual,
      through his or her employer) is an advisor or consultant to the Company or
      any
      Subsidiary.

     

    “Corporate
      Charter”
shall
      mean the Articles of Association of the Company, and any subsequent amendments
      or replacements thereto. 

     

    “Disability”
      shall
      have the meaning ascribed to such term or a similar term in the Appendix under
      which an Award is made and/or a Participant's employment agreement (where
      applicable), or in the absence of such a definition, the inability of the
      Participant, in the opinion of a qualified physician acceptable to the Company,
      to perform the major duties of the Participant’s position with the Company
      because of the sickness or injury of the Participant for a consecutive period
      of
      180 days.

     

     “Fair
      Market Value”
      shall
      mean, unless otherwise provided in an Appendix, the value of Shares as of any
      date, determined as follows:

     

    (i)    If
      the Shares
      are listed on any established stock exchange or traded on the Nasdaq National
      Market or the Nasdaq Small Cap Market, the Fair Market Value of a Share of
      common stock of the Company shall be the closing sales price for such stock
      (or
      the closing bid, if no sales were reported) as quoted on such exchange or market
      (or the exchange or market with the greatest volume of trading in the common
      stock) on the last market trading day prior to the day of determination, as
      reported in The Wall Street Journal or such other source as the Board deems
      reliable.

     

    (ii)    In
      the
      absence of such markets for the Shares, the Fair Market Value shall be
      determined in good faith by the Board.

     

    “Options”
shall
      mean options to purchase Shares awarded under the Plan.

    
      
         

      

      
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    “Participant”
shall
      mean a recipient of an Award hereunder who executes an Award Agreement.

     

    “Restricted
      Stock”
means
      an Award of Shares under this Plan that is subject to the terms and conditions
      of Section 7.

     

     “Service
      Provider”
shall
      mean an employee, director, office holder or Consultant of the Company or its
      subsidiaries or affiliates.

     

    “Shares”
shall
      mean Ordinary Shares, nominal value NIS 0.01 per share, of the Company.

     

    “Transaction”
shall
      have the meaning set forth in Section 10.2.

     

    3.    Administration
      of the Plan.

     

    3.1    The
      Plan
      will be administered by the Administrator. If the Administrator is a Committee,
      such Committee will consist of such number of Directors of the Company (not
      less
      than two in number), as may be determined from time to time by the Board of
      Directors. The Board of Directors shall appoint such members of the Committee,
      may from time to time remove members from, or add members to, the Committee,
      and
      shall fill vacancies in the Committee however caused.

     

    3.2    The
      Committee, if appointed, shall select one of its members as its Chairman and
      shall hold its meetings at such times and places as it shall determine. Actions
      at a meeting of the Committee at which a majority of its members are present
      or
      acts approved in writing by all members of the Committee, shall be the valid
      acts of the Committee. The Committee shall appoint a Secretary, who shall keep
      records of its meetings and shall make such rules and regulations for the
      conduct of its business and the implementation of the Plan, as it shall deem
      advisable, subject to the directives of the Board of Directors and in accordance
      with applicable law.

     

    3.3    Subject
      to the general terms and conditions of the Plan, and in particular Section
      3.4
      below, the Administrator shall have full authority in its discretion, from
      time
      to time and at any time, to determine (i) eligible Participants, (ii) the number
      of Options or Shares to be covered by each Award, (iii) the time or times at
      which the Award shall be granted, (iv) the vesting schedule and other terms
      and
      conditions applying to Awards, (v) the form(s) of written agreements applying
      to
      Awards, and (vi) any other matter which is necessary or desirable for, or
      incidental to, the administration of the Plan and the granting of Awards. The
      Board of Directors may, in its sole discretion, delegate some or all of the
      powers listed above to the Committee, to the extent permitted by the Companies
      Law, its Corporate Charter or other applicable law. 

     

    3.4    No
      member
      of the Board of Directors or of the Committee shall be liable for any action
      or
      determination made in good faith with respect to the Plan or any Award granted
      hereunder. Subject to the Company’s decision and to all approvals legally
      required, each member of the Board or the Committee shall be indemnified and
      held harmless by the Company against any cost or expense (including counsel
      fees) reasonably

    
      
         

      

      
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    incurred
      by him or her, or any liability (including any sum paid in settlement of a
      claim
      with the approval of the Company) arising out of any act or omission to act
      in
      connection with the Plan unless arising out of such member's own willful
      misconduct or bad faith, to the fullest extent permitted by applicable law.
      Such
      indemnification shall be in addition to any rights of indemnification the member
      may have as a director or otherwise under the Company's Charter Documents,
      any
      agreement, any vote of stockholders or disinterested directors, insurance policy
      or otherwise.

     

    3.5    The
      interpretation and construction by the Administrator of any provision of the
      Plan or of any Option hereunder shall be final and conclusive. In the event
      that
      the Board appoints a Committee, the interpretation and construction by the
      Committee of any provision of the Plan or of any Option hereunder shall be
      conclusive unless otherwise determined by the Board of Directors. To avoid
      doubt, the Board of Directors may at any time exercise any powers of the
      Administrator, notwithstanding the fact that a Committee has been
      appointed.

     

    3.6    The
      Administrator shall have the authority to adopt, alter and repeal such
      administrative rules, guidelines and practices governing the Plan and perform
      all acts, including the delegation of its responsibilities (to the extent
      permitted by applicable law and applicable stock exchange rules), as it shall,
      from time to time, deem advisable; to construe and interpret the terms and
      provisions of the Plan and any Award issued under the Plan (and any agreements
      relating thereto); and to otherwise supervise the administration of the Plan.
      The Administrator may correct any defect, supply any omission or reconcile
      any
      inconsistency in the Plan or in any agreement relating thereto in the manner
      and
      to the extent it shall deem necessary to effectuate the purpose and intent
      of
      the Plan. Notwithstanding the foregoing, no action of the Administrator under
      this Section 3.7 not otherwise provided for herein or in an Award Agreement
      shall reduce the rights of any Participant without the Participant’s consent.

     

    3.7    Without
      limiting the generality of the foregoing, the Administrator may adopt special
      Appendices and/or guidelines and provisions for persons who are residing in
      or
      employed in, or subject to, the taxes of, any domestic or foreign jurisdictions,
      to comply with applicable laws, regulations, or accounting, listing or other
      rules with respect to such domestic or foreign jurisdictions.

     

    4.    Eligible
      Participants.

     

    4.1    No
      Award
      may be granted pursuant to the Plan to any person serving as a member of the
      Committee or to any other Director of the Company at the time of the grant,
      unless such grant is approved in the manner prescribed for the approval of
      compensation of directors under the Companies Law.

     

    4.2    Subject
      to the limitation set forth in Sub-section 4.1 above and any restriction imposed
      by applicable law, Awards may be granted to any Service Provider of the Company,
      whether or not a director of the Company or its affiliates. The
      grant
      of an Award to a Participant hereunder shall neither entitle such Participant
      to
      receive an additional Award or participate in other incentive plans of the
      Company, nor disqualify

    
      
         

      

      
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    such
      Participant from receiving and additional Award or participating in other
      incentive plans of the Company.

     

    5.    Reserved
      Shares. 

     

    The
      Company shall determine the number of Shares reserved hereunder from time to
      time, and such number may be increased or decreased by the Company from time
      to
      time. Any Shares under the Plan, in respect of which the right hereunder of
      a
      Participant to purchase the same shall for any reason terminate, expire or
      otherwise cease to exist, shall again be available for grant as Awards under
      the
      Plan. Any Shares that remain unissued and are not subject to Awards at the
      termination of the Plan shall cease to be reserved for purposes of the Plan.
      Until termination of the Plan the Company shall at all times reserve a
      sufficient number of Shares to meet the requirements of the Plan.

     

    6.    Award
      Agreement.

     

    6.1    The
      Board
      of Directors in its discretion may award to Participants Awards available under
      the Plan. The terms of the Award will be set forth in the Award Agreement.
      The
      date of grant of each Award shall be the date specified by the Board of
      Directors at the time such award is made, or in the absence of such
      specification, the date of approval of the award by the Board of
      Directors.

     

    6.2    The
      Award
      Agreement shall state, inter
      alia,
      the
      number of Options, Shares or equity-based units covered thereby, the type of
      Option, Share-based or other grant awarded, any special terms applying to such
      Award (if any), including the terms of any country-specific or other applicable
      Appendix, as determined by the Board of Directors.

     

    7.    Restricted
      Stock and Other Equity-Based Awards.

     

    7.1    Eligibility.
      Restricted Stock may be issued to all Participants either alone or in addition
      to other Awards granted under the Plan. The Administrator shall determine the
      eligible Participants to whom, and the time or times at which, grants of
      Restricted Stock will be made, the number of shares to be awarded, the purchase
      price (if any) to be paid by the Participant (subject to Section 7.2), the
      time
      or times at which such Awards may be subject to forfeiture (if any), the vesting
      schedule (if any) and rights to acceleration thereof, and all other terms and
      conditions of the Awards. The Adminstrator may condition the grant or vesting
      of
      Restricted Stock upon the attainment of specified performance targets or such
      other factors as the Adminstrator may determine, in its sole discretion. Unless
      otherwise determined by the Adminstrator, the Participant shall not be permitted
      to sell or transfer shares of Restricted Stock awarded under this Plan during
      a
      period set by the Adminstrator (if any) (the “Restriction
      Period”)
      commencing with the date of such Award, as set forth in the applicable Award
      Agreement.

     

    7.2    Terms.
      A
      Participant selected to receive Restricted Stock shall not have any rights
      with
      respect to such Award, unless and until such Participant has delivered a fully
      executed copy of the Award Agreement evidencing the Award to the Company and
      has
      otherwise complied with the applicable terms and conditions of such Award.
      The

    
      
         

      

      
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    purchase
      price of Restricted Stock shall be determined by the Administrator, but shall
      not be less than as permitted under applicable law. Awards of Restricted Stock
      must be accepted within a period of 60 days (or such shorter period as the
      Administrator may specify at grant) after the grant date, by executing an Award
      Agreement and by paying whatever price (if any) the Administrator has designated
      thereunder.

     

    7.3    Legend.
      Each
      Participant receiving Restricted Stock shall be issued a stock certificate
      in
      respect of such shares of Restricted Stock, unless the Administrator elects
      to
      use another system, such as book entries by the transfer agent, as evidencing
      ownership of Restricted Stock. Such certificate shall be registered in the
      name
      of such Participant, and shall bear an appropriate legend referring to the
      terms, conditions, and restrictions applicable to such Award, substantially
      in
      the following form (as well as other legend required by the Administrator
      pursuant to Section 19.3 below):

     

    “The
      anticipation, alienation, attachment, sale, transfer, assignment, pledge,
      encumbrance or charge of the shares of stock represented hereby are subject
      to
      the terms and conditions (including forfeiture) of the Rosetta Genomics Ltd.
      Global Incentive Plan (2006), and an Award Agreement entered into between the
      registered owner and the Company dated ____________. Copies of such Plan and
      Award Agreement are on file at Rosetta Genomics Ltd.”

     

    7.4    Custody.
      The
      Administrator may require that any certificates evidencing such shares be held
      in custody by the Company until the restrictions thereon shall have lapsed,
      and
      that, as a condition of any Restricted Stock Award, the Participant shall have
      delivered a duly signed power, endorsed in blank, relating to the Shares covered
      by such Award.

     

    7.5    Rights
      as Shareholder.
      Except
      as provided in this Section and Section 7.4 above and as otherwise determined
      by
      the Administrator and set forth in the Award Agreement, the Participant shall
      have, with respect to the Shares of Restricted Stock, all of the rights of
      a
      holder of Shares including, without limitation, the right to receive any
      dividends, the right to vote such shares and, subject to and conditioned upon
      the full vesting of shares of Restricted Stock, the right to tender such shares.
      Notwithstanding the foregoing, the payment of dividends shall be deferred until,
      and conditioned upon, the expiration of the applicable Restriction Period,
      unless the Administrator, in its sole discretion, specifies otherwise at the
      time of the Award.

     

    7.6    Lapse
      of Restrictions.
      If and
      when the Restriction Period expires without a prior forfeiture of the Restricted
      Stock subject to such Restriction Period, the certificates for such Shares
      shall
      be delivered to the Participant. All legends shall be removed from said
      certificates at the time of delivery to the Participant except as otherwise
      required by this Plan, the Award Agreement and applicable law. Notwithstanding
      the foregoing, actual certificates shall not be issued to the extent that book
      entry recordkeeping is used. 

    
      
         

      

      
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    7.7    Other
      Equity-Based Awards. Other
      equity-based Awards (including, without limitation, restricted stock units
      and
      performance share awards) may be granted either alone or in addition to or
      other
      Awards granted under the Plan to all eligible Participants pursuant to such
      terms and conditions as the Administrator may determine, including without
      limitation, in one or more appendix adopted by the administrator and appended
      to
      this Plan. 

     

    8.    Exercise
      of Option.

     

    8.1    Options
      shall be exercisable pursuant to the terms under which they were awarded and
      subject to the terms and conditions of the Plan and any applicable Appendix,
      as
      specified in the Award Agreement.

     

    8.2    The
      exercise price for each share to be issued upon exercise of an Option shall
      be
      such price as is determined by the Board in its discretion, provided that the
      price per Share is not less than the nominal value of each Share, or to the
      extent required pursuant to applicable law, not less than 100% of the Fair
      Market Value of a Share on the date of grant.

     

    8.3    An
      Option, or any part thereof, shall be exercisable by the Participant's signing
      and returning to the Company at its principal office (and to the Trustee, where
      applicable), a "Notice of Exercise" in such form and substance as may be
      prescribed by the Board of Directors from time to time, together with full
      payment for the Shares underlying such Option.

     

    8.4    Each
      payment for Shares under an Option shall be in respect of a whole number of
      Shares, shall be effected in cash or by check payable to the order of the
      Company, or such other method of payment acceptable to the Company as determined
      by the Administrator, and shall be accompanied by a notice stating the number
      of
      Shares being paid for thereby.

     

    8.5    Until
      the
      Shares are issued (as evidenced by the appropriate entry in the share register
      of the Company or of a duly authorized transfer agent of the Company) a
      Participant shall have no right to vote or right to receive dividends or any
      other rights as a shareholder shall exist with respect to such Shares,
      notwithstanding the exercise of the Option. The Company shall issue (or cause
      to
      be issued) such Shares promptly after the Option is exercised. No adjustment
      will be made for a dividend or other right the record date for which is prior
      to
      the date the Shares are issued, except as provided in Section 10 of the
      Plan.

     

    8.6    To
      the
      extent permitted by law, if the Share is traded on a national securities
      exchange, The Nasdaq Share Market or quoted on a national quotation system
      sponsored by the National Association of Securities Dealers or otherwise
      publicly traded or quoted, payment for the Shares underlying an Option may
      be
      made all or in part by the delivery (on a form prescribed by the Company) of
      an
      irrevocable direction to a securities broker approved by the Company to sell
      Shares and to deliver all or part of the sales proceeds to the Company in
      payment of the exercise price (or the relevant portion thereof,

    
      
         

      

      
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    as
      applicable) and any withholding taxes, or on such other terms and conditions
      as
      may be acceptable to the Administrator (including, without limitation, the
      relinquishment of Options or by payment in full or in part in the form of Share
      owned by the Participant for a period of at least six months or such other
      period necessary to avoid accounting treatment adverse to the Company (and
      for
      which the Participant has good title free and clear of any liens and
      encumbrances) based on the fair market value of the Share on the payment date
      as
      determined by the Administrator). No Shares shall be issued until payment has
      been made or provided for, as provided herein. 

     

    9.    Termination
      of Relationship as Service Provider.

     

    9.1    Effect
      of Termination; Exercise After Termination. Unless
      otherwise determined by the Administrator, if an Participant ceases to be a
      Service Provider, such Participant may exercise any outstanding Options within
      such period of time as is specified in the Award Agreement or the Plan to the
      extent that the Options are vested on the date of termination (but in no event
      later than the expiration of the term of the Option as set forth in the Option
      Agreement). If, on the date of termination, any Options are unvested, the Shares
      covered by the unvested portion of the Option shall revert to the Plan. If,
      after termination, the Participant does not exercise the vested Options within
      the time specified in the Award Agreement or the Plan, the Option shall
      terminate, and the Shares covered by such Option shall revert to the Plan.
      

     

    In
      the
      absence of a provision specifying otherwise in the relevant Award Agreement,
      then:

     

    (a) in
      the
      event that the Participant ceases to be a Service Provider for any reason other
      than termination for Cause, or as a result of the Participant's death or
      Disability: (i) the vested Options shall remain exercisable for a period of
      three (3) months from the Date of Termination or as set forth in Section 13
      and
      (ii) all Restricted Stock still subject to restriction under the applicable
      Restriction Period as of the Date of termination, as set forth in the Award
      Agreement, shall be forfeited;

     

    (b)
      in
      the event that the Participant ceases to be a Service Provider for Cause, (i)
      all Options will terminate immediately upon the date of such termination for
      cause, such that the unvested portion of the Options will not vest, and the
      vested portion of the Options will no longer be exercisable; and (ii) all
      Restricted Stock still subject to restriction under the applicable Restriction
      Period as of the Date of Termination, as set forth in the Award Agreement,
      shall
      be forfeited. 

     

    9.2    Date
      of Termination. For
      purposes of the Plan and any Option or Option Agreement, and unless otherwise
      set forth in the relevant Award Agreement, the “Date of Termination”(whether for
      Cause or otherwise) shall be the effective date of termination of the
      Participant's employment or engagement as a Service Provider. 

     

    9.3    Leave
      of Absence.
      Unless
      the Administrator provides otherwise, vesting of Awards granted hereunder shall
      be suspended during any unpaid leave of absence.

     

    9.4    Change
      of
      Status.
      A
      Service Provider shall not cease to be considered as such in the case of any
      (a)
      leave of absence approved by the Company, or (b) transfers between locations
      of
      the Company or between the Company, and its parent, subsidiary,

    
      
         

      

      
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    affiliate,
      or any successor thereof; or (c) changes in status (employee to director,
      employee to consultant, etc.) provided that such change does not affect the
      specific terms applying to the Service Provider’s Award. 

     

    10.    Adjustments.

     

    Upon
      the
      occurrence of any of the following described events, a Participant's rights
      to
      purchase Shares under the Plan shall be adjusted as hereinafter
      provided:

     

    10.1    Changes
      in Capitalization.
      Subject
      to any required action by the shareholders of the Company, the number of Shares
      covered by each outstanding Award, and the number of Shares which have been
      authorized for issuance under the Plan but as to which no Options or other
      Award
      have yet been granted or which have been returned to the Plan upon cancellation
      or expiration of an Option or other Award, as well as the price per Share
      covered by each such outstanding Option, shall be proportionately adjusted
      for
      any increase or decrease in the number of, or other change in, issued Shares
      or
      the capitalization of the Company, resulting from a stock split, reverse stock
      split, stock dividend, combination, exchange or reclassification of the Shares,
      or any other increase or decrease in the number of issued Shares effected
      without receipt of consideration by the Company, or, subject to the discretion
      of the Board, any repurchase of Shares, recapitalization, merger, issuance
      of
      warrants or rights, dividend or other distribution (other than ordinary cash
      dividends) to shareholders of the Company, spin-off, split-up or other similar
      corporate event or transaction. The conversion of any convertible securities
      of
      the Company shall not be deemed to have been “effected without receipt of
      consideration.” Such adjustment shall be made by the Board, whose determination
      in that respect shall be final, binding and conclusive. Except as expressly
      provided herein, no issuance by the Company of shares of stock of any class,
      or
      securities convertible into shares of stock of any class, shall affect, and
      no
      adjustment by reason thereof shall be made with respect to, the number or price
      of Shares subject to an Option or other Award.

     

    10.2    Merger,
      Acquisition, or Asset Sale. 

     

    (a)    In
      the event
      of (i) a merger or consolidation of the Company with or into another corporation
      resulting in such other corporation being the surviving entity or the direct
      or
      indirect parent of the Company or resulting in the Company being the surviving
      entity and any other person or entity owning fifty percent (50%) or more of
      the
      outstanding voting power of the Company's securities by virtue of the
      transaction, (ii) an acquisition of all or substantially all of the shares
      of
      the Company, or (iii) the sale of all or substantially all of the assets of
      the
      Company (each such event, a “Transaction”), the unexercised or restricted
      portion of each outstanding Award shall be assumed or an equivalent Award or
      right substituted, by the successor corporation or an affiliate of the successor
      corporation, as shall be determined by such entity, subject to the terms hereof.
      In the event that the successor corporation or a parent or subsidiary of the
      successor corporation does not provide for such an assumption or substitution
      of
      Options, all Options shall become exercisable in full on a date no later than
      ten (10) days prior to the date of consummation of the Transaction, provided
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    the
      Administrator, the exercise of all Options that otherwise would not have been
      exercisable in the absence of a Transaction, shall be contingent upon the actual
      consummation of the Transaction.

     

    (b)    For
      the
      purposes of this Section 10.2, an Option shall be considered assumed or
      substituted if, following a Transaction, the Option confers the right to
      purchase or receive, for each Share subject to the Option immediately prior
      to
      the Transaction, the consideration (whether stock, cash, or other securities
      or
      property) received in the merger or sale of Shares or assets by holders of
      Shares of the Company for each Share held on the effective date of the
      Transaction (and if holders were offered a choice of consideration, the type
      of
      consideration determined by the Administrator, at its sole discretion);
      provided, however, that if the consideration received in the Transaction is
      not
      solely ordinary shares or common stock (or the equivalent) of the successor
      corporation or its direct or indirect parent, the Administrator may, with the
      consent of the successor corporation, provide for the per share consideration
      to
      be received upon the exercise of the Option to be solely ordinary shares or
      common stock (or the equivalent) of the successor corporation or its direct
      or
      indirect parent equal in fair market value to the per share consideration
      received by holders of Shares in the Transaction, as determined by the
      Administrator.

     

    (c)    In
      the
      event that the Board of Directors determines in good faith that, in the context
      of a Transaction, certain Options have no monetary value and thus do not entitle
      the holders of such Options to any consideration under the terms of the
      Transaction, the Board of Directors may determine that such Options shall
      terminate effective as of the effective date of the Transaction.

     

    (d)    It
      is the
      intention that the Administrator’s authority to make determinations, adjustments
      and clarifications in connection with the treatment of Awards shall be
      interpreted as widely as possible, to allow the Administrator maximal power
      and
      flexibility to interpret and implement the provisions of the Plan in the event
      of Transaction, provided that the Administrator shall determine in good faith
      that a Participant’s rights previously accrued are not thereby materially
      adversely affected without the Participant’s express written
      consent.

     

    11.    Non-Transferability
      of Options and Shares.

     

    11.1    No
      Option
      may be transferred other than by will or by the laws of descent and
      distribution, and during the Participant's lifetime an Option may be exercised
      only by such Participant.

     

    11.2    Shares
      of
      Restricted Stock may not be assigned, transferred, pledged or mortgaged, other
      than by will or laws of descent and distribution, prior to the date on which
      the
      date on which any applicable restriction, performance or deferred period lapses.
      Shares for which full payment has not been made, may not be assigned,
      transferred, pledged or mortgaged, other than by will or laws of descent and
      distribution. For avoidance of doubt, the foregoing shall not be deemed to
      restrict the transfer of an Participant's rights in respect of Options or Shares
      purchasable pursuant to the exercise thereof upon the death of such Participant
      to such Participant’s estate or other successors

    
      
         

      

      
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    by
      operation of law or will, whose rights therein shall be governed by Section
      9.1(a) hereof, and as may otherwise be determined by the
      Administrator.

     

    12.    Term
      and Amendment of the Plan.

     

    12.1    The
      Plan
      shall expire on the date which is ten (10) years from the date of its adoption
      by the Board of Directors (except as to Options outstanding on that
      date).

     

    12.2    Notwithstanding
      any other provision of the Plan, the Board (or a duly authorized Committee
      thereof) may at any time, and from time to time, amend, in whole or in part,
      any
      or all of the provisions of the Plan (including any amendment deemed necessary
      to ensure that the Company may comply with any regulatory requirement), or
      suspend or terminate it entirely, retroactively or otherwise; provided, however,
      that, except (x) to correct obvious drafting errors or as otherwise required
      by
      law or (y) as specifically provided herein, the previously accrued rights of
      a
      Participant with respect to Awards granted prior to such amendment, suspension
      or termination, may not be materially impaired without the consent of such
      Participant. The Administrator may amend the terms of any Award theretofore
      granted, prospectively or retroactively, but except (x) to correct obvious
      drafting errors or as otherwise required by law or applicable accounting rules,
      or (y) as specifically provided herein, no such amendment or other action by
      the
      Committee shall materially impair the previously accrued rights of any
      Participant without the Participant’s consent.

     

    13.    Term
      of Option. 

     

    Unless
      otherwise explicitly provided in an Award Agreement, if any Option, or any
      part
      thereof, has not been exercised and the Shares covered thereby not paid for
      within ten (10) years after the date on which the Option was granted, as set
      forth in the Award Agreement (or any other period set forth in the instrument
      granting such Option pursuant to Section 6), such Option, or such part thereof,
      and the right to acquire such Shares shall terminate, all interests and rights
      of the Participant in and to the same shall expire, and, in the event that
      in
      connection therewith any Shares are held in trust as aforesaid, such trust
      shall
      expire.

     

    14.    Continuance
      of Engagement.
      

     

    Neither
      the Plan nor any offer of Shares or Options to a Participant shall impose any
      obligation on the Company or a related company thereof, to continue the
      employment or engagement of any Participant as a Service Provider, and nothing
      in the Plan or in any Option granted pursuant thereto shall confer upon any
      Participant any right to continue to serve as a Service Provider of the Company
      or a related company thereof or restrict the right of the Company or a related
      company thereof to terminate such employment or engagement at any
      time.

     

    15.    Governing
      Law.

     

    The
      Plan
      and all instruments issued thereunder or in connection therewith, shall be
      governed by, and interpreted in accordance with, the laws of the State of
      Israel.

    
      
         

      

      
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    16.    Application
      of Funds. 

     

    The
      proceeds received by the Company from the sale of Shares pursuant to Options
      granted under the Plan will be used for general corporate purposes of the
      Company or any related company thereof.

     

    17.    Taxes. 

     

    17.1    Any
      tax
      consequences arising from the grant, vesting or exercise of any Award, from
      the
      payment for Shares covered thereby, or from any other event or act (of the
      Company, and/or its affiliates, or the Participant), hereunder shall be borne
      solely by the Participant. The Company and/or its affiliates shall withhold
      taxes according to the requirements under the applicable laws, rules, and
      regulations, including withholding taxes at source. Furthermore, the Participant
      shall agree to indemnify the Company and/or its affiliates and hold them
      harmless against and from any and all liability for any such tax or interest
      or
      penalty thereon, including without limitation, liabilities relating to the
      necessity to withhold, or to have withheld, any such tax from any payment made
      to the Participant. The Company or any of its affiliates may make such
      provisions and take such steps as it may deem necessary or appropriate for
      the
      withholding of all taxes required by law to be withheld with respect to Awards
      granted under the Plan and the exercise thereof, including, but not limited,
      to
      (i) deducting the amount so required to be withheld from any other amount (or
      Shares issuable) then or thereafter to be provided to the Participant, including
      by deducting any such amount from a Participant’s salary or other amounts
      payable to the Participant, to the maximum extent permitted under law and/or
      (ii) requiring the Participant to pay to the Company or any of its affiliates
      the amount so required to be withheld as a condition of the issuance, delivery,
      distribution or release of any Shares and/or (iii) by causing the exercise
      of
      any Options and sale of Shares held by on behalf of the Participant to cover
      such liability. In addition, the Participant will be required to pay any amount
      due in excess of the tax withheld and transferred to the tax authorities,
      pursuant to applicable tax laws, regulations and rules.

     

    17.2    The
      receipt of an Award and/or the acquisition of Shares issued upon the exercise
      of
      the Options may result in tax consequences. The description of tax consequences
      set forth in the Plan or any Appendix hereto does not purport to be complete,
      up
      to date or to take into account any special circumstances relating to a
      Participant. 

     

    17.3    THE
      PARTICIPANT IS ADVISED TO CONSULT WITH A TAX ADVISOR WITH RESPECT TO THE TAX
      CONSEQUENCES OF RECEIVING OR EXERCISING ANY AWARD IN LIGHT OF HIS OR HER
      PARTICULAR CIRCUMSTANCES.

     

    
      
        18.    Market
          Stand-Off

      

    

     

    
      
         

      

      
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              If
                so requested by the Company or any representative of the underwriters
                (the
                “Managing Underwriter”) in connection with any registration of the
                offering of any securities of the Company under the securities laws
                of any
                jurisdiction, the Participant shall not sell or otherwise transfer
                any
                Shares or other securities of the Company during a 180-day period
                or such
                other period as may be requested in writing by the Managing Underwriter
                and agreed to in writing by the Company (the “Market Standoff Period”)
                following the effective date of registration statement of the Company
                filed under such securities laws. The Company may impose stop transfer
                instructions with respect to securities subject to the foregoing
                restrictions until the end of such Market Standoff Period.
                

            

    

     

    19.    Conditions
      Upon Issuance of Shares. 

     

    19.1    Legal
      Compliance.
      Shares
      shall not be issued pursuant to the exercise of an Option or with respect to
      any
      other Award unless the exercise of such Option or grant of such Award and the
      issuance and delivery of such Shares shall comply with applicable laws and
      shall
      be further subject to the approval of counsel for the Company with respect
      to
      such compliance. The inability of the Company to obtain authority from any
      regulatory body having jurisdiction, which authority is deemed by the Company’s
      counsel to be necessary to the lawful issuance and sale of any Shares hereunder,
      shall relieve the Company of any liability in respect of the failure to issue
      or
      sell such Shares as to which such requisite authority shall not have been
      obtained.

     

    19.2    Investment
      Representations. As
      a
      condition to the exercise of an
      Option
      or receipt of an Award, the Board may require the person exercising such Option
      or receiving such Award to represent and warrant at the time of any such
      exercise or the time of receipt of the Award that the Shares are being purchased
      only for investment and without any present intention to sell or distribute
      such
      Shares, and make other representations as may be required under applicable
      securities laws if, in the opinion of counsel for the Company, such
      representations are required, all in form and content specified by the
      Board.

     

    19.3    Legend.
      The
      Administrator may require each person receiving Shares pursuant to an Award
      granted under the Plan to represent to and agree with the Company in writing
      that the Participant is acquiring the shares without a view to distribution
      thereof and such other securities law related representations as the
      Administrator shall request. In addition to any legend required by the Plan,
      the
      certificates for such shares may include any legend which the Administrator
      deems appropriate to reflect any applicable restrictions on
      transfer. All
      certificates for Shares delivered under the Plan shall be subject to such stock
      transfer orders and other restrictions as the Administrator may deem advisable
      under the rules, regulations and other requirements of any relevant securities
      authority, any stock exchange upon which the Shares are then listed or any
      national securities association system upon whose system the Shares are then
      quoted, any applicable securities law, and any applicable corporate law, and
      the
      Administrator may

    
      
         

      

      
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    cause
      a
      legend or legends to be put on any such certificates to make appropriate
      reference to such restrictions.

     

    20.    Miscellaneous.

     

    Whenever
      applicable in the Plan, the singular and the plural, and the masculine, feminine
      and neuter shall be freely interchangeable, as the context requires. The Section
      headings or titles shall not in any way control the construction of the language
      herein, such headings or titles having been inserted solely for the purpose
      of
      simplified reference. Words such as “herein”, “hereof”, “hereto”, “hereinafter”,
“hereby”, and “hereinabove” when used in the Plan refer to the Plan as a whole,
      including any applicable Appendices, unless otherwise required by
      context.

    

    *  *  *

     

    
      
         

      

      
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    APPENDIX
      - ISRAELI TAXPAYERS

    
      

      ROSETTA
        GENOMICS LTD. 

      GLOBAL
        SHARE INCENTIVE PLAN (2006) 

       

      
        
          1.    Special
            Provisions for Israeli Taxpayers

        

      

       

      1.1 This
        Appendix (the “Appendix”)
        to the
        Rosetta Genomics Ltd. Global Share Incentive Plan (2006) (the “Plan”)
        is
        effective as of _________, 2006 (the “Effective
        Date”).

       

      1.2 The
        provisions specified hereunder apply only to persons who are deemed to be
        residents of the State of Israel for tax purposes, or are otherwise subject
        to
        taxation in Israel with respect to Awards. 

       

      1.3 This
        Appendix applies with respect to Awards granted as Options or Shares under
        the
        Plan. The purpose of this Appendix is to establish certain rules and limitations
        applicable to Options and Shares that may be granted or issued under the
        Plan
        from time to time, in compliance with the securities and other applicable
        laws
        currently in force in the State of Israel. Except as otherwise provided by
        this
        Appendix, all grants made pursuant to this Appendix shall be governed by
        the
        terms of the Plan. This Appendix is applicable only to grants made after
        the
        Effective Date. This Appendix complies with, and is subject to the ITO and
        Section 102. 

       

      1.4 The
        Plan
        and this Appendix shall be read together. In any case of contradiction, whether
        explicit or implied, between the provisions of this Appendix and the Plan,
        the
        provisions of this Appendix shall govern.

       

      2.    Definitions

       

      Capitalized
        terms not otherwise defined herein shall have the meaning assigned to them
        in
        the Plan. The following additional definitions will apply to grants made
        pursuant to this Appendix:

       

      “3(i)
        Option”
means
        an Option which is subject to taxation pursuant to Section 3(i) of the ITO
        which
        has been granted to any person who is not an Eligible 102
        Participant.

       

      “102
        Capital Gains Track”
means
        the tax alternative set forth in Section 102(b)(2) of the ITO pursuant to
        which
        income resulting from the sale of Shares derived from Options is taxed as
        a
        capital gain.

       

      “102
        Capital Gains Track Grant”
means
        a
        102 Trustee Grant qualifying for the special tax treatment under the 102
        Capital
        Gains Track.

       

      “102
        Ordinary Income Track”
means
        the tax alternative set forth in Section 102(b)(1) of the ITO pursuant to
        which
        income resulting from the sale of Stock derived from Options is taxed as
        ordinary income.

       

      “102
        Ordinary Income Track Grant”
means
        a
        102 Trustee Grant qualifying for the ordinary income tax treatment under
        the 102
        Ordinary Income Track.

       

      “102
        Trustee Grant”
means
        an Award of Options or Shares granted pursuant to Section 102(b) of the ITO
        and
        held in trust by a Trustee for the benefit of the Participant, and includes
        both
        102 Capital Gains Track Grants and 102 Ordinary Income Track
        Grants.

      
        
           

        

        
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      “Affiliate”
means
        any “employing company” within the meaning of Section 102(a) of the
        ITO.

       

      “Controlling
        Shareholder”
ameans
        a “controlling shareholder” within the meaning of Section 32(9) of the
        Ordinance, currently defined as an individual who prior to the grant or as
        a
        result of the grant or exercise of any Award, holds or would hold, directly
        or
        indirectly, in his name or with a relative (as defined in the Ordinance)
        (i) 10%
        of the outstanding shares of the Company, (ii) 10% of the voting power of
        the
        Company, (iii) the right to hold or purchase 10% of the outstanding equity
        or
        voting power, (iv) the right to obtain 10% of the “profit” of the Company (as
        defined in the Ordinance), or (v) the right to appoint a director of the
        Company.

       

      “Election”
means
        the Company's choice of the type (as between capital gains track or ordinary
        income track) of 102 Trustee Grants it will make under the Plan, as filed
        with
        the ITA.

       

      “Eligible
        102 Participant”
means
        a
        person who is employed by the Company or its Affiliates, including an individual
        who is serving as a director or an office holder, who is not a Controlling
        Shareholder. 

       

      “Fair
        Market Value”
shall
        mean with respect to 102 Capital Gains Track Grants only, for the sole purpose
        of determining tax liability pursuant to Section 102(b)(3) of the ITO, if
        at the
        date of grant the Company’s shares are listed on any established stock exchange
        or a national market system or if the Company’s shares will be registered for
        trading within ninety (90) days following the date of grant, the fair market
        value of the Shares at the date of grant shall be determined in accordance
        with
        the average value of the Company’s shares on the thirty (30) trading days
        preceding the date of grant or on the thirty (30) trading days following
        the
        date of registration for trading, as the case may be.

       

      “ITA”
means
        the Israeli Tax Authorities.

       

      “ITO”
means
        the Israeli Income Tax Ordinance (New Version) 1961 and the rules, regulations,
        orders or procedures promulgated thereunder and any amendments thereto,
        including specifically the Rules, all as may be amended from time to
        time.

       

      “Non-Trustee
        Grant”
means
        an Award granted to an Eligible 102 Participant pursuant to Section 102(c)
        of
        the ITO and not held in trust by a Trustee.

       

      “Required
        Holding Period”
means
        the requisite period prescribed by the ITO and the Rules, or such other period
        as may be required by the ITA, with respect to 102 Trustee Grants, during
        which
        Options or Shares granted by the Company must be held by the Trustee for
        the
        benefit of the person to whom it was granted. Currently, the Required Holding
        Period for 102 Capital Gains Track Grants is 24 months from the date of grant
        of
        the Options. 

       

      “Rules”
        means
        the Income Tax Rules (Tax benefits in Stock Issuance to Employees)
        5763-2003.

       

      “Section
        102”
shall
        mean the provisions of Section 102 of the ITO, as amended from time to time,
        including by the Law Amending the Income Tax Ordinance (Number 132), 2002,
        effective as of January 1, 2003 and by the Law Amending the Income Tax Ordinance
        (Number 147), 2005.

       

      "Shares"
        means
        shares of Stock, including Restricted or Unrestricted Stock or shares of
        Stock
        issued upon exercise of Stock Options.

      
        
           

        

        
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      “Stock
        Option”
means
        a
        Stock Option granted pursuant to the terms and conditions of the Plan and
        the
        Appendix.

       

      “Trustee”
means
        a
        person or entity designated by the Board to serve as a trustee and approved
        by
        the ITA in accordance with the provisions of Section 102(a) of the
        ITO.

       

      
        
          3.    Types
            of Awards and Section 102 Election

        

      

       

      3.1 Awards
        made pursuant to Section 102, whether as grants of Options or as issuances
        of
        Shares under the Plan, shall be made pursuant to either (a) Section 102(b)(2)
        of
        the ITO as 102 Capial Gains Track Grants or (b) Section 102(b)(1) of the
        ITO as
        102 Ordinary Income Track Grants. The Company’s Election regarding the type of
        102 Trustee Grant it chooses to make shall be filed with the ITA. Once the
        Company has filed such Election, it may change the type of 102 Trustee Grant
        that it chooses to make only after the passage of at least 12 months from
        the
        end of the calendar year in which the first grant was made in accordance
        with
        the previous Election, in accordance with Section 102. For the avoidance
        of
        doubt, such Election shall not prevent the Company from granting Non-Trustee
        Grants to Eligible 102 Participants at any time. 

       

      3.2 Eligible
        102 Participants may receive only 102 Trustee Grants or Non-Trustee Grants
        under
        this Appendix. Participants who are not Eligible 102 Participants may be
        granted
        only 3(i) Options under this Appendix.

       

      3.3 No
        102
        Trustee Grants may be made effective pursuant to this Appendix until 30 days
        after the requisite filings required by the ITO and the Rules have been made
        with the ITA. 

       

      3.4 The
        option agreement or documents evidencing the Options granted or Shares issued
        pursuant to the Plan and this Appendix shall indicate whether the grant is
        a 102
        Trustee Grant, a Non-Trustee Grant or a 3(i) Grant; and, if the grant is
        a 102
        Trustee Grant, whether it is a 102 Capital Gains Track Grant or a 102 Ordinary
        Income Track Grant.

       

      
        
          4.    Terms
            And Conditions Of 102 Trustee Options

        

      

       

      4.1 Each
        102
        Trustee Grant will be deemed granted on the date stated in a written notice
        by
        the Company, provided that effective as of such date (i) the Company has
        provided such notice to the Trustee and (ii) the Participant has signed all
        documents required pursuant to this Section 4.

       

      4.2 Each
        102
        Trustee Grant granted to an Eligible 102 Participant and each certificate
        for
        shares of Stock acquired pursuant to the exercise of a Option or issued directly
        as Shares shall be issued to and registered in the name of a Trustee and
        shall
        be held in trust for the benefit of the Participant for the Required Holding
        Period. After termination of the Required Holding Period, the Trustee may
        release such Option and any such Shares, provided that (i) the Trustee has
        received an acknowledgment from the Israeli Income Tax Authority that the
        Eligible 102 Participant has paid any applicable tax due pursuant to the
        ITO or
        (ii) the Trustee and/or the Company or its Affiliate withholds any applicable
        tax due pursuant to the ITO. The Trustee shall not release any 102 Trustee
        Options or shares issued upon exercise of such Option prior to the full payment
        of the Eligible 102 Participant’s tax liabilities.

      
        
           

        

        
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      4.3 Each
        102
        Trustee Grant (whether a 102 Capital Gains Track Grant or a 102 Ordinary
        Income
        Track Grant, as applicable) shall be subject to the relevant terms of Section
        102 and the ITO, which shall be deemed an integral part of the 102 Trustee
        Option and shall prevail over any term contained in the Plan, this Appendix
        or
        any agreement that is not consistent therewith. Any provision of the ITO
        and any
        certificates or rulings of the ITA not expressly specified in this Appendix
        or
        Option Agreement which are necessary to receive or maintain any tax benefit
        pursuant to the Section 102 shall be binding on the Eligible 102 Participant.
        The Trustee and the Eligible 102 Participant granted a 102 Trustee Grant
        shall
        comply with the ITO, and the terms and conditions of the Trust Agreement
        entered
        into between the Company and the Trustee. For avoidance of doubt, it is
        reiterated that compliance with the ITO specifically includes compliance
        with
        the Rules. Further, the Eligible 102 Participant agrees to execute any and
        all
        documents which the Company or the Trustee may reasonably determine to be
        necessary in order to comply with the provision of any applicable law, and,
        particularly, Section 102. 

       

      4.4 During
        the Required Holding Period, the Eligible 102 Participant shall not require
        the
        Trustee to release or sell the Options or Shares and other shares received
        subsequently following any realization of rights derived from Shares or Options
        (including stock dividends) to the Eligible 102 Participant or to a third
        party,
        unless permitted to do so by applicable law. Notwithstanding the foregoing,
        the
        Trustee may, pursuant to a written request and subject to applicable law,
        release and transfer such Shares to a designated third party, provided that
        both
        of the following conditions have been fulfilled prior to such transfer:
        (i) all taxes required to be paid upon the release and transfer of the
        shares have been withheld for Transfer to the tax authorities and (ii) the
        Trustee has received written confirmation from the Company that all requirements
        for such release and transfer have been fulfilled according to the terms
        of the
        Company’s corporate documents, the Plan, any applicable agreement and any
        applicable law. To avoid doubt such sale or release during the Required Holding
        Period will result in different tax ramifications to the Eligible 102
        Participant under Section 102 of the ITO and the Rules and/or any other
        regulations or orders or procedures promulgated thereunder, which shall apply
        to
        and shall be borne solely by such Eligible 102 Participant.

       

      4.5 In
        the
        event a stock dividend is declared and/or additional rights are granted with
        respect to Shares which derive from Awards granted as 102 Trustee Grants,
        such
        dividend and/or rights shall also be subject to the provisions of this Section
        4
        and the Required Holding Period for such shares and/or rights shall be measured
        from the commencement of the Required Holding Period for the Award with respect
        to which the dividend was declared and/or rights granted.  
        In the
        event of a cash dividend on Shares, the Trustee shall transfer the dividend
        proceeds to the Eligible 102 Participant after deduction of taxes and mandatory
        payments in compliance with applicable withholding requirements.

       

      4.6 If
        an
        Option granted as a 102 Trustee Grant is exercised during the Required Holding
        Period, the Shares issued upon such exercise shall be issued in the name
        of the
        Trustee for the benefit of the Eligible 102 Participant. If such an Option
        is
        exercised after the Required Holding Period ends, the Shares issued upon
        such
        exercise shall, at the election of the Eligible 102 Participant, either (i)
        be
        issued in the name of the Trustee, or (ii) be transferred to the Eligible
        102
        Participant directly, provided that the Participant first complies with all
        applicable provisions of the Plan.

      
        
           

        

        
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      5.    Assignability

       

      As
        long
        as Options or Shares are held by the Trustee on behalf of the Eligible 102
        Participant, all rights of the Eligible 102 Participant over the shares are
        personal, can not be transferred, assigned, pledged or mortgaged, other than
        by
        will or laws of descent and distribution.

       

      
        
          6.    Tax
            Consequences

        

      

       

      6.1 Any
        tax
        consequences arising from the grant of any Award, exercise of any Option,
        from
        the issuance, sale or transfer of Shares, or from any other event or act
        (of the
        Company, and/or its Affiliates, and the Trustee or the Participant) relating
        to
        an Award or Shares issued thereupon , shall be borne solely by the Participant.
        The Company and/or its Affiliates, and/or the Trustee shall withhold taxes
        according to the requirements under the applicable laws, rules, and regulations,
        including withholding taxes at source. Furthermore, the Participant shall
        agree
        to indemnify the Company and/or its Affiliates and/or the Trustee and hold
        them
        harmless against and from any and all liability for any such tax or interest
        or
        penalty thereon, including without limitation, liabilities relating to the
        necessity to withhold, or to have withheld, any such tax from any payment
        made
        to the Participant. The Company or any of its Affiliates and the Trustee
        may
        make such provisions and take such steps as it/they may deem necessary or
        appropriate for the withholding of all taxes required by law to be withheld
        with
        respect to Awards granted under the Plan and the exercise, sale, transfer
        or
        other disposition thereof, including, but not limited, to (i) deducting the
        amount so required to be withheld from any other amount then or thereafter
        payable to a Participant, including by deducting any such amount from a
        Participant's salary or other amounts payable to the Participant, to the
        maximum
        extent permitted under law and/or (ii) requiring a Participant to pay to
        the
        Company or any of its Affiliates the amount so required to be withheld as
        a
        condition of the issuance, delivery, distribution or release of any Shares
        and/or (iii) by causing the execise of Options and/or sale of Shares held
        by or
        on behalf of the Participant to cover such liability. In addition, the
        Participant will be required to pay any amount that exceeds the tax to be
        withheld and transferred to the tax authorities, pursuant to applicable Israeli
        tax regulations.

       

      6.2 With
        respect to Non-Trustee Grants, if the Participant ceases to be employed by
        the
        Company or any Affiliate, the Eligible 102 Participant shall extend to the
        Company and/or its Affiliate a security or guarantee for the payment of tax
        due
        at the time of sale of Shares to the satisfaction of the Company, all in
        accordance with the provisions of Section 102 of the ITO and the
        Rules.

       

      
        
          7.    Governing
            Law and Jurisdiction

        

      

       

      Notwithstanding
        any other provision of the Plan, with respect to Participants subject to
        this
        Appendix, the Plan and all instruments issued thereunder or in connection
        therewith shall be governed by, and interpreted in accordance with, the laws
        of
        the State of Israel applicable to contracts made and to be performed therein.
        

      

      * * *

      
        
           

        

        
          Page
            5 of 5

          
            

          

        

        
           

        

      

       

      APPENDIX
        - U.S. TAXPAYERS 

      
         

        ROSETTA
          GENOMICS LTD., GLOBAL SHARE INCENTIVE PLAN (2005)

         

         

        
          
            1.    Special
              Provisions for Persons who are U.S. Residents 

          

        

         

        1.1 This
          Appendix (the “Appendix”)
          to the
          Rosetta Genomics Ltd. Global Share Incentive Plan (2005) (the “Plan”)
          is
          effective as of _____, 2006 (the “Effective
          Date”).

         

        1.2 The
          provisions specified hereunder apply only to persons who are subject to
          U.S.
          federal income tax (any such person, a “U.S.
          Taxpayer”).
          

         

        1.3 This
          Appendix applies with respect to Options granted under the Plan. The purpose
          of
          this Appendix is to establish certain rules and limitations applicable
          to
          Options that may be granted or issued under the Plan from time to time,
          in
          compliance with applicable tax, securities and other applicable laws currently
          in force. Except as otherwise provided by this Appendix, all grants made
          pursuant to this Appendix shall be governed by the terms of the Plan (including,
          without limitation, its provisions regarding adjustments). This Appendix
          is
          applicable only to grants made after the Effective Date. 

         

        1.4 The
          Plan
          and this Appendix shall be read together. In any case of an irreconcilable
          contradiction (as determined by the Administrator) between the provisions
          of
          this Appendix and the Plan, the provisions of the Plan shall govern unless
          expressly stated otherwise in this Appendix.

         

        1.5 
          The Plan
          and this Appendix shall be submitted to the Company’s shareholders for approval
          within twelve (12) months after the Effective Date. 

         

        2.    Definitions

         

        Capitalized
          terms not otherwise defined herein shall have the meaning assigned to them
          in
          the Plan. The following additional definitions will apply to grants made
          pursuant to this Appendix:

         

        “Affiliate”
          means
          each of the following: (a) any Subsidiary; (b) any Parent; (c) any corporation,
          trade or business (including, without limitation, a partnership or limited
          liability company) that is directly or indirectly controlled 50% or more
          (whether by ownership of stock, assets or an equivalent ownership interest
          or
          voting interest) by the Company or one of its Subsidiaries or Parents,
          if any;
          and (d) any other entity in which the Company or any of its Affiliates has
          a material equity interest and that is designated as an “Affiliate” by
          resolution of the Administrator provided,
          however,
          that,
          notwithstanding any other provisions of the Plan or this Appendix to the
          contrary, for purposes of Non-Qualified Stock Options, if an individual
          who
          otherwise qualifies as a Service Provider provides services to such an
          entity
          and not to the Company or a Subsidiary or Parent, such entity may only
          be
          designated an Affiliate if the Company qualifies as a “service recipient,”
within the meaning of Code Section 409A, with respect to such individual;
          provided further
          that
          such definition of “service recipient” shall be determined by (i) applying Code
          Section 1563(a)(1), (2) and (3), for purposes of determining a controlled
          group
          of corporations under Code Section 414(b), using the

        
          
             

          

          
             

            
              

            

          

          
             

          

        

         

        language
          “at least 50 percent” instead of “at least 80 percent” each place it appears in
          Code Section 1563(a)(1), (2) and (3), and by applying Treasury Regulations
          Section 1.414(c)-2, for purposes of determining trades or businesses (whether
          or
          not incorporated) that are under common control for purposes of Code Section
          414(c), using the language “at least 50 percent” instead of “at least 80
          percent” each place it appears in Treasury Regulations Section 1.414(c)-2, and
          (ii) where the use of Shares with respect to the grant of a Non-Qualified
          Stock
          Option to such an individual is based upon legitimate business criteria,
          by
          applying Code Section 1563(a)(1), (2) and (3), for purposes of determining
          a
          controlled group of corporations under Code Section 414(b), using the language
          “at least 20 percent” instead of “at least 80 percent” at each place it appears
          in Code Section 1563(a)(1), (2) and (3), and by applying Treasury Regulations
          Section 1.414(c)-2, for purposes of determining trades or businesses (whether
          or
          not incorporated) that are under common control for purposes of Code Section
          414(c), using the language “at least 20 percent” instead of “at least 80
          percent” at each place it appears in Treasury Regulations Section
          1.414(c)-2.

         

        “Code”
          means
          the Internal Revenue Code of 1986, as amended. Any reference to any section
          of
          the Code shall also be a reference to any successor provision and any Treasury
          Regulation promulgated thereunder.

         

        “Disability”
          means,
          with respect to Incentive Stock Options, a “permanent and total disability” as
          set forth in Section 22(e)(3) of the Code.

        

        “Exchange
          Act”
          means
          the Securities Exchange Act of 1934, as amended. Any references to any
          section
          of the Exchange Act shall also be a reference to any successor
          provision.

         

        “Fair
          Market Value”
          means,
          for purposes of this Appendix, unless otherwise required by any applicable
          provision of the Code or any regulations issued thereunder, as of any date
          and
          except as provided below, the last sales price reported for the Share on
          such
          date: (a) as reported on the principal national securities exchange in
          the
          United States on which it is the traded or The Nasdaq Stock Market; or
          (b) if
          not traded on any such national securities exchange or The Nasdaq Stock
          Market,
          as quoted on an automated quotation system sponsored by the National Association
          of Securities Dealers, Inc. or if the Share shall not have been reported
          or
          quoted on such date, on the first day prior thereto on which the Share
          was
          reported or quoted; provided, that the Administrator may modify the definition
          of Fair Market Value to reflect any changes in the trading practices of
          any
          exchange on which the Share is listed or traded. If the Share is not readily
          tradable on a national securities exchange, The Nasdaq Stock Market or
          any
          automated quotation system sponsored by the National Association of Securities
          Dealers, Inc., its Fair Market Value shall be set in good faith by the
          Administrator. Notwithstanding any provision herein to the contrary, with
          respect to Non-Qualified Stock Options, the “Fair Market Value” of the Shares
          shall be determined in a manner that satisfies the applicable requirements
          of
          Code Section 409A, and with respect to Incentive Stock Options, such Fair
          Market
          Value shall be determined in a manner that satisfies the applicable requirements
          of Code Section 422, and subject to Code Section 422(c)(7).

        
          
             

          

          
            Page
              2

            
              

            

          

          
             

          

        

         

        “Family
          Member”
          means
“family member” as defined in Rule 701 under the Securities Act or, following
          the filing of a Form S-8 pursuant to the Securities Act with respect to
          the
          Plan, any child, stepchild, grandchild, parent, stepparent, grandparent,
          spouse,
          former spouse, sibling, niece, nephew, mother-in-law, father-in-law, son-in-law,
          daughter-in-law, brother-in-law, or sister-in-law, including adoptive
          relationships, any person sharing the employee’s household (other than a tenant
          or employee), a trust in which these persons have more than 50% of the
          beneficial interest, a foundation in which these persons (or the employee)
          control the management of assets, and any other entity in which these persons
          (or the employee) own more than 50% of the voting interests or as otherwise
          defined in Rule 701 under the Securities Act or in Section A(1)(a)(5) of
          the
          general instructions of Form S-8, as applicable.

         

        “Incentive
          Stock Option”
          means
          any Option awarded to an eligible Participant under the Plan and this Appendix
          intended to be and designated in the Award Agreement as an “incentive stock
          option” within the meaning of Section 422 of the Code.

         

        “Non-Qualified
          Stock Option”
          means
          any Option awarded under this Plan that is not an Incentive Stock
          Option.

         

        “Parent”
          means
          any parent corporation of the Company within the meaning of Section 424(e)
          of
          the Code.

         

        “Public
          Trading Date”
          means
          the first date upon which the Shares are listed (or approved for listing)
          upon
          notice of issuance on any U.S. securities exchange or designated (or approved
          for designation) upon notice of issuance as a U.S. national market security
          on
          an interdealer quotation system.

        

        “Restricted
          Stock”
means
          Shares acquired pursuant to the exercise of an unvested Option in accordance
          with Section 3.2 below.

        

        “Section
          83(b) Election”
means
          an election by a Participant to include the Fair Market Value of a Share
          (less
          any amount paid for the Share) at the time of grant as part of the Participant’s
          income in accordance with Section 83(b) of the Code. A Section 83(b) Election
          must be filed in writing with the Internal Revenue Service within thirty
          (30)
          days of the date of the Award, with a copy to the Company or Affiliate
          with whom
          the Participant is employed. 

        

        “Securities
          Act”
          means
          the Securities Act of 1933, as amended, and all rules and regulations
          promulgated thereunder. Any reference to any section of the Securities
          Act shall
          also be a reference to any successor provision.

         

        “Subsidiary”
          means
          any subsidiary corporation of the Company within the meaning of Section
          424(f)
          of the Code.

         

        “Ten
          Percent Shareholder”
          means a
          person owning stock possessing more than 10% of the total combined voting
          power
          of all classes of stock of the Company, its Subsidiaries or its
          Parent.

        
          
             

          

          
            Page
              3

            
              

            

          

          
             

          

        

         

        3.    Grants
          of Options. 

         

        3.1 The
          Administrator shall have full authority to grant Options to Participants
          pursuant to the terms of this Appendix and the Plan. All Options shall
          be
          granted by, confirmed by, and subject to the terms of, a written agreement
          to be
          executed by the Company and the Participant. In particular, the Administrator
          shall have the authority to determine whether a Option is an Incentive
          Stock
          Option or Non-Qualified Stock Option.

         

        3.2 Early
          Exercise.
          Subject
          to Section 1.5 of this Appendix, the Administrator may provide that a
          Non-Qualified Stock Option include a provision whereby the Participant
          may elect
          at any time before the termination of a Participant’s employment or engagement
          as a Service Provider to exercise an Option as to any part or all of the
          Shares
          subject to the Option prior to the full vesting of the Option and such
          shares
          shall be subject to certain restrictions as determined by the Administrator
          and
          be treated as Restricted Stock. Any unvested Shares so purchased may be
          subject
          to a repurchase option in favor of the Company or to any other restriction
          the
          Administrator determines to be appropriate.

         

        3.3 Termination. 

        

        (a)
          If a
          Participant ceases to be a Service Provider other than by reason of the
          Participant’s Disability or death, such Holder may exercise his or her Option
          within such period of time as is specified in the Plan or the Award Agreement
          to
          the extent that the Option is vested on the date of termination. 

        

        (b)
          If a
          Participant ceases to be a Service Provider as a result of the Participant’s
          Disability, the Participant may exercise his or her Option within such
          period of
          time as is specified in the Plan or the Award Agreement to the extent the
          Option
          is vested on the date of termination.

        

        (c)
          If a
          Participant dies while a Service Provider, the Option may be exercised
          within
          such period of time as is specified in the Plan or the Award
          Agreement.

        

        To
          avoid
          doubt, the provisions of Section 9 of the Plan shall remain in full force
          and
          effect and apply to Options granted pursuant to this Appendix.

        

        4.    Shares
          Reserved under Appendix. 

         

        The
          aggregate number of Shares with respect to which Options may be granted
          under
          this Appendix shall not exceed ___________ (subject to any increase or
          decrease
          approved by the Board of Directors), which includes all authorized and
          unissued
          Share designated for such purpose. In
          determining the number of Shares available for Options, if Shares have
          been
          delivered or surrendered by a Participant as full or partial payment to
          the
          Company for payment of the exercise price, or for payment of withholding
          taxes,
          or if the number Shares otherwise deliverable has been reduced for payment
          of
          the exercise price

        
          
             

          

          
            Page
              4

            
              

            

          

          
             

          

        

         

        or
          for
          payment of withholding taxes, the number of Shares surrendered as payment
          in
          connection with the exercise or for withholding or reduced shall again
          be
          available for purposes of Options under this Appendix. Notwithstanding
          the foregoing, the maximum number of Shares that may be issued pursuant
          to
          Incentive Stock Options is 773,796 Shares, and such reserve of Shares for
          grants
          of Incentive Stock Options shall not be increased without the approval
          of the
          shareholders of the Company as required pursuant to Section 421 et
          seq.
          of the
          Code. The numbers of Shares stated in this Section 4 shall be subject to
          adjustment as provided in Section 10.1 of the Plan.

         

        5.    Special
          Terms for Incentive Stock Options.

         

        5.1 Eligibility.
          All
          Service Providers are eligible to be granted Non-Qualified Stock Options
          under
          this Appendix, and all employees of the Company, a Subsidiary or a Parent
          are
          eligible to be granted Incentive Stock Options under this Appendix, if
          so
          employed on the grant date of such Incentive Stock Option, although it
          is
          anticipated that grants hereunder will be granted solely or primarily to
          U.S.
          Taxpayers. Eligibility for the grant of an Option and actual participation
          in
          this Appendix and the Plan shall be determined by the Administrator in
          its sole
          discretion. Notwithstanding anything in this Section 5.1 to the contrary,
          Consultants who are not natural persons that provide bona fide services
          to the
          Company, a Subsidiary or a Parent and Consultants who provide services
          in
          connection with the offer or sale of securities in a capital raising transaction
          or within the meaning of Rule 701 of the Securities Act shall not be eligible
          to
          be granted Options under this Appendix.

         

        5.2 Disqualification.
          To
          the
          extent that any Option does not qualify as an Incentive Stock Option (whether
          because of its provisions or the time or manner of its exercise or otherwise),
          such Option or the portion thereof that does not qualify shall constitute
          a
          separate Non-Qualified Stock Option. 

         

        5.3 Exercise
          Price.
          The
          exercise price per Share subject to an Option shall be determined by the
          Administrator at the time of grant of such Option; provided that the per
          share
          exercise price of an Option shall not be less than 100% of the Fair Market
          Value
          of the Share at the time of grant of such Option; and provided, further,
          that if
          an Option is granted to a Ten Percent Shareholder, the exercise price per
          Share
          shall be no less than 110% of the Fair Market Value of the Share at the
          time of
          the grant of such Option.

         

        5.4 Option
          Term.
          The term
          of each Option shall be fixed by the Administrator; provided, however,
          that no
          Option shall be exercisable more than 10 years after the date such Option
          is
          granted; and further provided that the term of an Incentive Stock Option
          granted
          to a Ten Percent Shareholder shall not exceed five years.

         

        5.5 Incentive
          Stock Option Limitations.
          To the
          extent that the aggregate Fair Market Value (determined as of the time
          of grant)
          of a Share with respect to which Incentive Stock Options are exercisable
          for the
          first time by an employee during any calendar year under this Plan and/or
          any
          other stock option plan of the Company, any Subsidiary or any Parent exceeds
          $100,000, such Options shall be treated as Non-Qualified Stock Options.
          In
          addition, if an employee does not remain employed by the Company, any Subsidiary
          or any Parent at all times from the time an Incentive Stock Option is granted
          until three months prior to the date of exercise thereof (or such
          other

        
          
             

          

          
            Page
              5

            
              

            

          

          
             

          

        

         

        period
          as
          required by Section 422 of the Code), such Option shall be treated as a
          Non-Qualified Stock Option. Should any provision of this Appendix not be
          necessary in order for the Options to qualify as Incentive Stock Options,
          or
          should any additional provisions be required, the Administrator may amend
          this
          Appendix accordingly, without the necessity of obtaining the approval of
          the
          shareholders of the Company, unless required by applicable law.

         

         

        5.6 Effect
          of Termination.
          Notwithstanding anything to the contrary in the Plan or this Appendix,
          and in
          the absence of a provision specifying otherwise in the relevant Award Agreement,
          then with respect to Incentive Stock Options, the following provisions
          must be
          met on order for the Award to qualify as an Incentive Stock Option under
          the
          Code:

         

        (a) in
          the
          event that the Participant ceases to be an employee of the Company or an
          Affiliate for any reason other than the Participant's death or Disability,
          the
          vested Options must be exercised within three (3) months from
          the
          effective date of termination of the Participant’s status as a Service
          Provider;

         

        (b)
          in
          the event that the Participant ceases to be a Service Provider as a result
          of
          the Participant's death or Disability, the Option must be exercised within
          twelve (12) months following the Participant's date of termination for
          death or
          Disability. 

         

        To
          avoid
          doubt, the provisions of Section 9 of the Plan and Section 3.4 of this
          Appendix
          shall remain in full force and effect and apply to Awards granted as Incentive
          Stock Options. The restrictions set forth above represent special additional
          limitations that apply to qualify as Incentive Stock Options under the
          provisions of the Code. To avoid doubt, a Participant may choose to exercise
          Options in accordance with the terms of Section 9 of the Plan or Section
          3.4 of
          the Appendix and the relevant Award Agreement, and not in compliance with
          the
          provisions of the Code relating to “incentive stock options”. In that case such
          Option will not qualify as an Incentive Stock Option and will be treated
          as a
          Non- Qualified Stock Option.  

         

        6.    Special
          Terms for Restricted Stock

         

        In
          accordance with the terms of the Code, a Participant shall be responsible
          for
          payment of all taxes incurred in connection with the grant of Restricted
          Stock.
          Accordingly, upon the vesting of Restricted Stock, or upon making a Section
          83(b) Election, a Participant shall make provision for the payment of all
          required withholding to the Company in accordance with Section 16.1 of
          the Plan.

         

        7.    Repurchase
          Provisions

         

        The
          Administrator in its sole discretion may provide that the Company may repurchase
          Shares acquired upon exercise of an Option pursuant to the Plan and this
          Appendix upon the occurrence of certain specified events, including, without
          limitation, a Participant’s termination as a Service Provider, divorce,
          bankruptcy or insolvency;

        
          
             

          

          
            Page
              6

            
              

            

          

          
             

          

        

         

        provided,
          however,
          that any
          such repurchase right shall be set forth in the applicable Award Agreement
          or
          Restricted Stock purchase agreement or in another agreement referred to
          in such
          agreement.

         

        8.    Amendment
          of Appendix and Individual Awards.

         

        8.1 This
          Appendix shall terminate ten (10) years following the first date of its
          approval
          by the Board of Directors. This Appendix may otherwise be amended or terminated
          in accordance with the terms governing the amendment or termination of
          the Plan;
          provided, however, that without the approval of the shareholders of the
          Company
          entitled to vote in accordance with applicable law, no amendment may be
          made
          that would: (i) increase the aggregate number of Shares that may be issued
          under this Appendix; (ii) change the classification of individuals eligible
          to receive Options under this Appendix; (iii) decrease the minimum exercise
          price of any Option below the amounts specified herein; (iv) extend the
          term of
          the Plan under Section 12.1 of the Plan or the maximum Option period under
          Section 5.4 of this Appendix; or (v) require shareholder approval in order
          for
          the Appendix to continue to comply with Section 422 of the Code to the
          extent
          applicable to Incentive Stock Options or require shareholder approval under
          the
          rules of any exchange or system on which the Company’s securities are listed or
          traded at the request of the Company.

         

        8.2 The
          Administrator may, to the extent permitted by the Plan and this Appendix,
          amend
          the terms of any Option theretofore granted, prospectively or retroactively,
          but, subject to the Plan or as otherwise specifically provided herein,
          no such
          amendment or other action by the Administrator shall materially impair
          the
          previously accrued rights of any holder of such Option without the holder’s
          consent.

         

        8.3 Notwithstanding
          any other provisions of the Plan or this Appendix to the contrary, (a)
          the
          Administrator may amend the Plan, this Appendix or any Award without the
          consent
          of the holder thereof if the Administrator determines that such amendment
          is
          required or advisable for the Company, the Plan, this Appendix or any Award
          to
          satisfy, comply with or meet the requirements of any law, regulation, rule
          or
          accounting standard, and (b) none of the Company, the Board or the Administrator
          shall take any action pursuant to Section 8 or Section 9 of this Appendix
          or
          Section 10 or Section 12.2 of the Plan, or otherwise, that would cause
          an Award
          that is otherwise exempt under Code Section 409A to become subject to Code
          Section 409A, or that would cause an Award that is subject to Code Section
          409A
          to fail to satisfy the requirements of Code Section 409A.

         

        9.    Transferability
          of Options. 

         

        No
          Option
          shall be transferable by the Participant otherwise than by will or by the
          laws
          of descent and distribution, and all Options shall be exercisable, during
          the
          Participant’s lifetime, only by the Participant. Notwithstanding the foregoing,
          the Committee may determine, in its sole discretion, at the time of grant
          or
          thereafter that a Non-Qualified Stock Option that is otherwise not transferable
          pursuant to this Section is transferable to a

        
          
             

          

          
            Page
              7

            
              

            

          

          
             

          

        

         

        Family
          Member in whole or in part and in such circumstances, and under such conditions,
          as specified by the Committee. A Non-Qualified Stock Option that is transferred
          to a Family Member pursuant to the preceding sentence (i) may not be
          subsequently transferred otherwise than by will or by the laws of descent
          and
          distribution and (ii) remains subject to the terms of the Plan, the Appendix
          and
          the applicable Award agreement. Any shares of Common Stock acquired upon
          the
          exercise of a Non-Qualified Stock Option by a permissible transferee of
          a
          Non-Qualified Stock Option or a permissible transferee pursuant to a transfer
          after the exercise of the Non-Qualified Stock Option shall be subject to
          the
          terms of the Plan, the Appendix and the applicable Award Agreement.

         

        10.    Deferred
          Compensation.

         

        To
          the
          extent that the Administrator determines that any Award granted under the
          Plan
          and this Appendix is subject to Section 409A of the Code, the Award Agreement
          evidencing such Award shall incorporate the terms and conditions required
          by
          Section 409A of the Code. To the extent applicable,
          the
          Plan, this Appendix and the Award Agreements shall be interpreted in accordance
          with Section 409A of the Code and Department of Treasury regulations and
          other
          interpretive guidance issued thereunder, including without limitation any
          such
          regulations or other guidance that may be issued after the Effective Date.
          Notwithstanding any provision of the Plan or this Appendix to the contrary,
          in
          the event that following the Effective Date the Administrator determines
          that
          any Award may be subject to Section 409A of the Code and related Department
          of
          Treasury guidance (including such Department of Treasury guidance as may
          be
          issued after the Effective Date), the Administrator may adopt such amendments
          to
          the Plan or the Appendix and the applicable Award Agreement or adopt other
          policies and procedures (including amendments, policies and procedures
          with
          retroactive effect), or take any other actions, that the Administrator
          determines are necessary or appropriate to (a) exempt the Award from Section
          409A of the Code and/or preserve the intended tax treatment of the benefits
          provided with respect to the Award, or (b) comply with the requirements
          of
          Section 409A of the Code and related Department of Treasury guidance.
The
          Administrator may permit deferrals of compensation pursuant to the terms
          of a
          Participant’s Award Agreement, a separate plan, or an Appendix that (in each
          case) meets the requirements of Code Section 409A. 

         

        *  *  *

        
          
             

          

            Page
              8INDEMNIFICATION
      UNDERTAKING 

    dated
      as of ________ __, 2006 

    

    from
      Rosetta Genomics Ltd. to [________________]

    (the
      “Office Holder”) 

    

     

    In
      respect of your service as a director or office holder of Rosetta Genomics
      Ltd.
      (the “Company”), the Company desires to provide for your indemnification to the
      fullest extent permitted by law. To that end, the Company hereby agrees as
      follows:

     

    1. The
      Company hereby undertakes to indemnify you to the maximum extent permitted
      by
      the Companies Law - 1999 (the “Companies Law”) in respect of the
      following:

     

    1.1 any
      financial obligation imposed on you in favor of another person by, or expended
      by you as a result of, a court judgment, including a settlement or an
      arbitrator’s award approved by court, in respect of any act or omission
      (“action”) taken or made by you in your capacity as a director or office holder
      of the Company; 

     

    1.2 all
      reasonable litigation expenses, including reasonable attorneys’ fees, expended
      by you or charged to you by a court, in a proceeding instituted against you
      by
      the Company or on its behalf or by another person, or in any criminal
      proceedings in which you are acquitted, or in any criminal proceedings of a
      crime which does not require proof of mens
      rea
      (criminal intent) in which you are convicted, all in respect of actions taken
      by
      you in your capacity as a director or officer of the Company; and 

     

    1.3 all
      reasonable litigation expenses, including reasonable attorneys’ fees, expended
      by you due to an investigation or a proceeding instituted against you by an
      authority qualified to conduct such investigation or proceeding, where such
      investigation or proceeding is concluded without the filing of an indictment
      against you (as defined in the Companies Law) and without any financial
      obligation imposed on you in lieu of criminal proceedings (as defined in the
      Companies Law), or that is concluded without your indictment but with a
      financial obligation imposed on you in lieu of criminal proceedings with respect
      to a crime that does not require proof of mens
      rea
      (criminal intent), all in respect of actions taken by you in your capacity
      as a
      director or office holder of the Company;

     

    2. The
      Company will not indemnify you for any amount you may be obligated to pay in
      respect of:

     

    2.1 a
      breach
      of your duty of loyalty to the Company, except, to the extent permitted by
      the
      Companies Law, for a breach of a duty of loyalty to the Company while acting
      in
      good faith and having reasonable cause to assume that such act would not
      prejudice the interests of the Company;

     

    2.2 a
      willful
      or reckless breach of the your duty of care to the Company;

     

    2.3 an
      action
      taken or omission by you with the intent of unlawfully realizing personal
      gain;

     

    2.4 a
      fine or
      penalty imposed upon you for an offense; and

     

    2.5 a
      counterclaim brought by the Company or in its name in connection with a claim
      against the Company filed by you, other than by way of defense or by way of
      third party notice in connection with a claim brought against you by the
      Company, or in specific cases in which the Company’s Board of Directors has
      approved the initiation or bringing of such suit by you, which approval shall
      not be unreasonably withheld.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    3. The
      Company will make available all amounts payable to you in accordance with
      Section 1 above on the date on which such amounts are first payable by you
      (“Time of Indebtedness”), including with respect to any claim against you
      initiated by the Company or in its right, and with respect to items referred
      to
      in Sections 1.2 and 1.3 above, not later than the date on which the applicable
      court renders its decision. Advances given to cover legal expenses in criminal
      proceedings will be repaid by you to the Company if you are found guilty of
      a
      crime which requires proof of criminal intent. Other advances will be repaid
      by
      you to the Company if it is determined that you are not lawfully entitled to
      such indemnification. As part of the aforementioned undertaking, the Company
      will make available to you any security or guarantee that you may be required
      to
      post in accordance with an interim decision given by a court or an arbitrator,
      including for the purpose of substituting liens imposed on your
      assets.

     

    4. The
      Company will indemnify you even if at the relevant Time of Indebtedness you
      are
      no longer a director or office holder of the Company provided that the
      obligations with respect to which you will be indemnified hereunder are in
      respect of actions taken by you while you were a director or office holder
      of
      the Company as aforesaid, and in such capacity.

     

    5. The
      indemnification will be limited to the expenses mentioned in Sections 1.2 and
      1.3 (pursuant and subject to Section 3 and insofar as indemnification with
      respect thereto is not restricted by law or by the provisions of Section 2
      above) and to the expenses mentioned in Section 1.1 above insofar as they result
      from, or are connected to, events and circumstances set forth in Schedule
      A
      hereto,
      which are deemed by the Company's Board of Directors, based on the current
      activity of the Company, to be foreseeable as of the date hereof. 

     

    6. The
      indemnification that the Company undertakes towards all persons whom it has
      resolved to indemnify for the matters and in the circumstances described herein,
      jointly and in the aggregate, shall not exceed $30 million (the “Maximum
      Liability Amount”), provided that if the Maximum Liability Amount is
      insufficient to cover all amounts to which such persons are entitled pursuant
      to
      such undertaking of the Company, the Maximum Liability Amount shall be allocated
      among such persons pro rata to the amounts to which they are so entitled. You
      acknowledge that you have been advised by the Company of the current Maximum
      Liability Amount.

     

    7. The
      Company will not indemnify you for any liability with respect to which you
      have
      received payment by virtue of an insurance policy or another indemnification
      agreement other than for amounts which are in excess of the amounts actually
      paid to you pursuant to any such insurance policy or other indemnity agreement
      (including deductible amounts not covered by insurance policies), within the
      limits set forth in Section 6 above.

     

    8. Subject
      to the provisions of Sections 6 and 7 above, the indemnification hereunder
      will,
      in each case, cover all sums of money that you will be obligated to pay, in
      those circumstances for which indemnification is permitted under the law and
      under this Indemnification Undertaking.

     

    9. The
      Company will be entitled to any amount collected from a third party in
      connection with liabilities indemnified hereunder. 

     

    10. In
      all
      indemnifiable circumstances, indemnification will be subject to the
      following:

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    10.1 You
      shall
      promptly notify the Company of any legal proceedings initiated against you
      and
      of all possible or threatened legal proceedings without delay following your
      first becoming aware thereof, however, your failure to notify the Company as
      aforesaid shall not derogate from your right to be indemnified as provided
      herein (except to the extent that such failure to notify causes the Company
      damages). You shall deliver to the Company, or to such person as it shall advise
      you, without delay all documents you receive in connection with these
      proceedings. Similarly, you must advise the Company on an ongoing and current
      basis concerning all events which you suspect may give rise to the initiation
      of
      legal proceedings against you in connection with your actions or omissions
      as a
      director or office holder of the Company.

     

    10.2 Other
      than with respect to proceedings that have been initiated against you by the
      Company or in its name, the Company shall be entitled to undertake the conduct
      of your defense in respect of such legal proceedings and/or to hand over the
      conduct thereof to any attorney which the Company may choose for that purpose,
      except to an attorney who is not, upon reasonable grounds, acceptable to you.
      The Company shall notify you of any such decision to defend with ten (10)
      calendar days of receipt of notice of any such proceeding. The Company and/or
      the attorney as aforesaid shall be entitled, within the context of the conduct
      as aforesaid, to conclude such proceedings, all as it shall see fit, including
      by way of settlement. At the request of the Company, you shall execute all
      documents required to enable the Company and/or its attorney as aforesaid to
      conduct your defense in your name, and to represent you in all matters connected
      therewith, in accordance with the aforesaid. For the avoidance of doubt, in
      the
      case of criminal proceedings the Company and/or the attorneys as aforesaid
      will
      not have the right to plead guilty in your name or to agree to a plea-bargain
      in
      your name without your consent. However, the aforesaid will not prevent the
      Company and/or its attorneys as aforesaid, with the approval of the Company,
      to
      come to a financial arrangement with a plaintiff in a civil proceeding without
      your consent so long as such arrangement will not be an admittance of an
      occurrence not indemnifiable pursuant to this Indemnification Undertaking and/or
      pursuant to law. The Company shall not, without your prior written consent,
      consent to the entry of any judgment against you or enter into any settlement
      or
      compromise which (i) includes an admission of your fault, (ii) does not include,
      as an unconditional term thereof, the full release of you from all liability
      in
      respect of such proceeding or (iii) is not fully indemnifiable pursuant to
      this
      Indemnification Undertaking and/or pursuant to law. This paragraph shall not
      apply to a proceeding brought by you under Section 10.7 below.

     

    10.3 You
      will
      fully cooperate with the Company and/or any attorney as aforesaid in every
      reasonable way as may be required of you within the context of their conduct
      of
      such legal proceedings, including but not limited to the execution of power(s)
      of attorney and other documents, provided that the Company shall cover all
      costs
      incidental thereto such that you will not be required to pay the same or to
      finance the same yourself.

     

    10.4 Notwithstanding
      the provisions of Sections 10.2 and 10.3 above, (i) if in a proceeding to which
      you are a party by reason of your status as a director or officer of the Company
      and the named parties to any such proceeding include both you and the Company
      or
      any subsidiary of the Company, a conflict of interest or potential conflict
      of
      interest (including the availability to the Company and its subsidiary, on
      the
      one hand, and you, on the other hand, of different or inconsistent defenses
      or
      counterclaims) exists between you and the Company, or (ii) if the Company fails
      to assume the defense of such proceeding in a timely manner, you shall be
      entitled to be represented by separate legal counsel, which shall represent
      other persons similarly situated, of the Company’s choice and reasonably
      acceptable to you and other person’s choice, at the expense of the Company. In
      addition, if the Company fails to comply with any of its material obligations
      under this Indemnification Undertaking or in the event that the Company or
      any
      other person takes any action to declare this Indemnification Undertaking void
      or unenforceable, or institutes any action, suit or proceeding to deny or to
      recover from you the benefits intended to be provided to you hereunder, except
      with respect to such actions, suits or proceedings brought by the Company that
      are resolved in favor of the Company, you shall have the right to retain counsel
      of your choice, and reasonably acceptable to the Company and at the expense
      of
      the Company, to represent you in connection with any such matter.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    10.5 If,
      in
      accordance with Section 10.2 (but subject to Section 10.4), the Company has
      taken upon itself the conduct of your defense, the Company will have no
      liability or obligation pursuant to this Indemnification Undertaking or the
      above resolutions to indemnify you for any legal expenses, including any legal
      fees, that you may expend in connection with your defense, unless (i) the
      Company shall not have assumed the conduct of your defense as contemplated,
      (ii)
      the Company refers the conduct of your defense to an attorney who is not, upon
      reasonable grounds, acceptable to you, (iii) the named parties to any such
      action (including any impleaded parties) include both you and the Company,
      and
      joint representation is inappropriate under applicable standards of professional
      conduct due to a conflict of interest between you and the Company, or (iv)
      the
      Company shall agree to such expenses in either of which events all reasonable
      fees and expenses of your counsel shall be borne by the Company.

     

    10.6 The
      Company will have no liability or obligation pursuant to this Indemnification
      Undertaking to indemnify you for any amount expended by you pursuant to any
      compromise or settlement agreement reached in any suit, demand or other
      proceeding as aforesaid without the Company’s consent to such compromise or
      settlement.

     

    10.7 If
      required by law, the Company’s authorized organs will consider the request for
      indemnification and the amount thereof and will determine if you are entitled
      to
      indemnification and the amount thereof. In the event that you make a request
      for
      payment of an amount of indemnification hereunder or a request for an
      advancement of indemnification expenses hereunder and the Company fails to
      determine your right to indemnification hereunder or fails to make such payment
      or advancement, you may petition any court which has jurisdiction to enforce
      the
      Company’s obligations hereunder. The Company agrees to reimburse you in full for
      any reasonable expenses incurred by you in connection with investigating,
      preparing for, litigating, defending or settling any action brought by you
      under
      the immediately preceding sentence, except where such action or any claim or
      counterclaim in connection therewith is resolved in favor of the
      Company.

     

    11. The
      Company hereby exempts you, to the fullest extent permitted by law, from any
      liability for damages caused as a result of a breach of your duty of care to
      the
      Company, provided that in no event shall you be exempt with respect to any
      actions listed in Section 2 above or breach of your duty of care in connection
      with distribution of Company's assets.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    12. The
      Company undertakes that in the event of a Change in Control (as defined below)
      of the Company, the Company’s obligations under this Indemnification Undertaking
      shall continue to be in effect following such Change in Control, and the Company
      shall take all reasonable necessary action to ensure that the party acquiring
      control of the Company shall independently undertake to continue in effect
      such
      Indemnification Undertaking, to maintain the provisions of the Articles of
      Association allowing indemnification and to indemnify you in the event that
      the
      Company shall not have sufficient funds or otherwise shall not be able to
      fulfill its obligations hereunder. For purposes of this Indemnification
      Undertaking, a “Change in Control” shall be deemed to have occurred if: (i) any
“Person” (as such term is used in Sections 13(d) and 14(d) of the U.S.
      Securities Exchange Act of 1934, as amended (the “Exchange Act”)), other than a
      trustee or other fiduciary holding securities under an employee benefit plan
      of
      the Company or a corporation owned directly or indirectly by the shareholders
      of
      the Company in substantially the same proportions as their ownership of shares
      of the Company, is or becomes the “Beneficial Owner” (as defined in Rule 13d-3
      under the Exchange Act), directly or indirectly, of securities of the Company
      representing 15% or more of the total voting power represented by the Company’s
      then outstanding voting securities; or (ii) during any period of two consecutive
      years (not including any period prior to the execution of this Indemnification
      Undertaking), individuals who at the beginning of such period constitute the
      Board of Directors of the Company and any new director (other than a director
      designated by a person who has entered into an agreement with the Company to
      effect a transaction described in clause (i), (iii) or (iv) of this Section
      12)
      whose election by the Board of Directors or nomination for election by the
      Company’s shareholders was approved by a vote of at least two-thirds of the
      directors then still in office who either were directors at the beginning of
      the
      period or whose election or nomination for election was previously so approved,
      cease for any reason to constitute at least a majority of the members of the
      Board of Directors; or (iii) a merger or consolidation of the Company with
      any
      other entity, other than a merger or consolidation which would result in the
      voting securities of the Company outstanding immediately prior thereto
      continuing to represent (either by remaining outstanding or by being converted
      into voting securities of the surviving entity) more than 51% of the combined
      voting power of the voting securities of the surviving entity outstanding
      immediately after such merger or consolidation and with the power to elect
      at
      least a majority of the Board of Directors or other governing body of such
      surviving entity; or (iv) the shareholders of the Company approve a plan of
      complete liquidation of the Company or an agreement for the sale or disposition
      by the Company of all or substantially all the Company’s assets; or (v) there
      occurs any other event of a nature that would be required to be reported in
      response to Item 6(e) of Schedule 14A of Regulation 14A (or a response to any
      similar item on any similar schedule or form) promulgated under the Exchange
      Act, whether or not the Company is then subject to such reporting
      requirement.

     

    13. The
      Company undertakes that if there is a Change in Control of the Company then
      with
      respect to all matters thereafter arising concerning your rights to payments
      under this Indemnification Undertaking or any other agreement or under the
      Company’s Articles of Association as now or hereafter in effect, the Company
      shall seek legal advice only from Independent Legal Counsel (as defined below)
      selected by the Company and approved by you (which approval shall not be
      unreasonably withheld). Such counsel, among other things, shall render its
      written opinion to the Company and you as to whether and to what extent you
      would be permitted to be indemnified under applicable law and the Company agrees
      to abide by such opinion. The Company agrees to pay the reasonable fees of
      the
      Independent Legal Counsel referred to above and to fully indemnify such counsel
      against any and all expenses (including attorneys’ fees), claims, liabilities
      and damages arising out of or relating to this Indemnification Undertaking
      or
      its engagement pursuant hereto. For purposes of this Indemnification
      Undertaking, “Independent Legal Counsel” shall mean an attorney or firm of
      attorneys who shall not have otherwise performed services for the Company or
      you
      within the last three years (other than with respect to matters concerning
      your
      rights under this Indemnification Undertaking, or of other indemnitees under
      similar indemnification undertakings).

     

    14. If
      for
      the validation of any of the undertakings in this Indemnification Undertaking
      any act, resolution, approval or other procedure is required, the Company
      undertakes to cause them to be done or adopted in a manner which will enable
      the
      Company to fulfill all its undertakings as aforesaid.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    15. For
      the
      avoidance of doubt, it is hereby clarified that nothing contained in this
      Indemnification Undertaking derogates from the Company’s right to indemnify you
      post factum for any amounts which you may be obligated to pay as set forth
      in
      Section 1 above without the limitations set forth in Sections 5 and 6
      above.

     

    16. If
      any
      undertaking included in this Indemnification Undertaking is held invalid or
      unenforceable, such invalidity or unenforceability will not affect any of the
      other undertakings which will remain in full force and effect. Furthermore,
      if
      such invalid or unenforceable undertaking may be modified or amended so as
      to be
      valid and enforceable as a matter of law, such undertaking will be deemed to
      have been modified or amended, and any competent court or arbitrator are hereby
      authorized to modify or amend such undertaking, so as to be valid and
      enforceable to the maximum extent permitted by law.

     

    17. This
      Indemnification Undertaking and the agreements herein shall be governed by
      and
      construed and enforced in accordance with the laws of the State of
      Israel.

     

    18. This
      Indemnification Undertaking cancels any preceding letter of indemnification
      or
      arrangement for indemnification that may have been issued to you by the
      Company.

     

    19. Neither
      the settlement or termination of any proceeding nor the failure of the Company
      to award indemnification or to determine that indemnification is payable shall
      create an adverse presumption that you are not entitled to indemnification
      hereunder. In addition, the termination of any proceeding by judgment or order
      (unless such judgment or order provides so specifically) or settlement, shall
      not create a presumption that you did not act in good faith and in a manner
      which you reasonably believed to be in or not opposed to the best interests
      of
      the Company or, with respect to any criminal action or proceeding, had
      reasonable cause to believe that your action was unlawful.

     

    20. This
      Indemnification Undertaking shall be (a) binding upon all successors and assigns
      of the Company (including any transferee of all or a substantial portion of
      the
      business, stock and/or assets of the Company and any direct or indirect
      successor by merger or consolidation or otherwise by operation of law), and
      (b)
      binding on and shall inure to the benefit of your heirs, personal
      representatives, executors and administrators. This Indemnification Undertaking
      shall continue for your benefit and your heirs', personal representatives',
      executors' and administrators' benefit after you cease to be a director or
      office holder of the Company.

     

    21. Except
      with respect to changes in the governing law which expand your right to be
      indemnified by the Company, no supplement, modification or amendment of this
      Indemnification Undertaking shall be binding unless executed in writing by
      each
      of the parties hereto. No waiver of any of the provisions of this
      Indemnification Undertaking shall be deemed or shall constitute a waiver of
      any
      other provisions of this Indemnification Undertaking (whether or not similar),
      nor shall such waiver constitute a continuing waiver.

     

    This
      Indemnification Undertaking is being issued to you pursuant to the resolutions
      adopted by the Board of Directors of the Company on April 24, 2006 and by the
      shareholders of the Company on July 12, 2006.
      The
      Board of Directors has determined, based on the current activity of the Company,
      that the amount stated in Section 6 is reasonable and that the events listed
      in
      Schedule A are reasonably anticipated.

     

    Kindly
      sign and return the enclosed copy of this letter to acknowledge your agreement
      to the contents hereof.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    

    Very
      truly yours,

    

    Rosetta
      Genomics Ltd.

    By: ______________________

    Name:

    Title:
      Chief Executive Officer

    Date:
      ________ __, 2006

    

    Accepted
      and agreed to:

    

     

    Name:
      _________________

    

    Date:
      ________ __, 2006

    

     

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    Schedule
      A

     

    
      	
              1.

            	
              Negotiations,
                execution, delivery and performance of agreements on behalf of the
                Company
                and any subsidiary thereof (“Subsidiary") including, inter alia, any claim
                or demand made by a customer, supplier, contractor or other third
                party
                transacting any form of business with the Company, its Subsidiaries
                or
                affiliates relating to the negotiations or performance of such
                transactions, representations or inducements provided in connection
                thereto or otherwise.

            

    

     

    
      	
              2.

            	
              Any
                claim or demand made in connection with any transaction which is
                not
                within the ordinary course of business of either the Company, its
                subsidiaries or affiliates, including the sale, lease or purchase
                of any
                assets or businesses.

            

    

     

    
      	
              3.

            	
              Anti-competitive
                acts and acts of commercial
                wrongdoing.

            

    

     

    
      	
              4.

            	
              Acts
                in regard of invasion of privacy including with respect to databases
                and
                acts in regard of slander.

            

    

     

    
      	
              5.

            	
              Any
                claim or demand made for actual or alleged infringement, misappropriation
                or misuse of any third party’s intellectual property rights including, but
                not limited to confidential information, patents, copyrights, design
                rights, service marks, trade secrets, copyrights, misappropriation
                of
                ideas by the Company, its Subsidiaries or
                affiliates.

            

    

     

    
      	
              6.
                

            	
              Actions
                taken in connection with the intellectual property of the Company
                and any
                Subsidiary and its protection, including the registration or assertion
                of
                rights to intellectual property and the defense of claims relating
                thereof.

            

    

     

    
      	
              7.
                

            	
              Participation
                and/or non-participation at the Company’s board meetings, bona fide
                expression of opinion and/or voting and/or abstention from voting
                at the
                Company’s board meetings.

            

    

     

    
      	
              8.

            	
              Approval
                of corporate actions including the approval of the acts of the Company’s
                management, their guidance and their
                supervision.

            

    

     

    
      	
              9.

            	
              Claims
                of failure to exercise business judgement and a reasonable level
                of
                proficiency, expertise and care in regard of the Company’s
                business.

            

    

     

    
      	
              10.

            	
              Violations
                of securities laws of any jurisdiction, including without limitation,
                fraudulent disclosure claims, failure to comply with SEC and/or the
                Israeli Securities Authority and/or any stock exchange disclosure
                or other
                rules and any other claims relating to relationships with investors,
                shareholders and the investment community and any claims related
                to the
                Sarbanes-Oxley Act of 2002, as amended from time to
                time.

            

    

     

    
      	
              11.

            	
              Any
                claim or demand made under any securities laws or by reference thereto,
                or
                related to the failure to disclose any information in the manner
                or time
                such information is required to be disclosed pursuant to such laws,
                or
                related to inadequate or improper disclosure of information to
                shareholders, or prospective shareholders, or related to the purchasing,
                holding or disposition of securities of the Company or any other
                investment activity involving or affected by such securities, including
                any actions relating to an offer or issuance of securities of the
                Company
                or of its subsidiaries and/or affiliates to the public by prospectus
                or
                privately by private placement, in Israel or abroad, including the
                details
                that shall be set forth in the documents in connection with execution
                thereof.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
              12.

            	
              Violations
                of laws requiring the Company to obtain regulatory and governmental
                licenses, permits and authorizations or laws related to any governmental
                grants in any jurisdiction.

            

    

     

    
      	
              13.

            	
              Claims
                in connection with publishing or providing any information, including
                any
                filings with any governmental authorities, on behalf of the Company
                in the
                circumstances required under any applicable
                laws

            

    

     

    
      	
              14.

            	
              Any
                claim or demand made by employees, consultants, agents or other
                individuals or entities employed by or providing services to the
                Company
                relating to compensation owed to them or damages or liabilities suffered
                by them in connection with such employment or
                service.

            

    

     

    
      	
              15.

            	
              Resolutions
                and/or actions relating to employment matters of the Company and/or
                its
                Subsidiaries and/or affiliates.

            

    

     

    
      	
              16.

            	
              Events,
                pertaining to the employment conditions of employees and to the employer
                -
                employee relations, including the promotion of workers, handling
                pension
                arrangements, insurance and saving funds, options and other
                benefits.

            

    

     

    
      	
              17.

            	
              Any
                claim or demand made by any lenders or other creditors or for moneys
                borrowed by, or other indebtedness of, the Company, its Subsidiaries
                or
                affiliates.

            

    

     

    
      	
              18.

            	
              Any
                claim or demand made by any third party suffering any personal injury
                and/or bodily injury and/or property damage to business or personal
                property through any act or omission attributed to the Company, its
                Subsidiaries or affiliates, or their respective employees, agents
                or other
                persons acting or allegedly acting on their
                behalf.

            

    

     

    
      	
              19.

            	
              Any
                claim or demand made directly or indirectly in connection with complete
                or
                partial failure, by the Company or any Subsidiary or affiliate thereof,
                or
                their respective directors, officers and employees, to pay, report,
                keep
                applicable records or otherwise, of any foreign, federal, state,
                country,
                local, municipal or city taxes or other compulsory payments of any
                nature
                whatsoever, including without limitation, income, sales, use, transfer,
                excise, value added, registration, severance, stamp, occupation,
                customs,
                duties, real property, personal property, capital stock, social security,
                unemployment, disability, payroll or employee withholding or other
                withholding, including any interest, penalty or addition thereto,
                whether
                disputed or not.

            

    

     

    
      	
              20.
                

            	
              Any
                claim or demand made by purchasers, holders, lessors or other users
                of
                products or assets of the Company, or individuals treated with such
                products, for damages or losses related to such use or
                treatment,
                and actions in connection with the testing of products developed
                by the
                Company and/or its Subsidiaries or in connection with the distribution,
                sale, license or use of such products.

            

    

     

    
      	
              21.
                

            	
              Any
                administrative, regulatory or judicial actions, orders, decrees,
                suits,
                demands, demand letters, directives, claims, liens, investigations
                proceedings or notices of noncompliance or violation by any governmental
                entity or other person alleging potential responsibility or liability
                (including potential responsibility or liability for costs of enforcement,
                investigation, cleanup, governmental response, removal or remediation,
                for
                natural resources damages, property damage, personal injuries, or
                penalties or contribution, indemnification, cost recovery, compensation,
                or injunctive relief) arising out of, based on or related to (x)
                the
                presence of, release spill, emission, leaking, dumping, pouring,
                deposit,
                disposal , discharge, leaching or migration into the environment
                (each a
                “Release”) or threatened Release of, or exposure to, any hazardous, toxic,
                explosive or radioactive substance, wastes or other substances or
                wastes
                of any nature regulated pursuant to any environmental law, at any
                location, whether or not owned, operated, leased or managed by the
                Company
                or any of its subsidiaries, or (y) circumstances forming the basis
                of any
                violation of any environmental law, environmental permit, license,
                registration or other authorization required under applicable
                environmental and/or public health
                law.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
              22.

            	
              Actions
                in connection with the Company’s development, use, sale, licensing,
                distribution, marketing or offer of products and/or
                services.

            

    

     

    
      	
              23.

            	
              Resolutions
                and/or actions relating to a merger of the company and/or of its
                subsidiaries and/or affiliates, the issuance of shares or securities
                exercisable into shares of the Company, changing the share capital
                of the
                Company, formation of subsidiaries, reorganization, winding up or
                sale of
                all or part of the business, operations or shares the
                Company.

            

    

     

    
      	
              24.

            	
              Resolutions
                and/or actions relating to investments in the Company and/or its
                subsidiaries and/or affiliated companies and/or the purchase or sale
                of
                assets, including the purchase or sale of companies and/or businesses,
                and/or investments in corporate or other entities and/or investments
                in
                traded securities and/or any other form of
                investment.

            

    

     

    
      	
              25.

            	
              Any
                administrative, regulatory or judicial actions, orders, decrees,
                suits,
                demands, demand letters, directives, claims, liens, investigations,
                proceedings or notices of noncompliance or violation by any governmental
                entity or other person alleging the failure to comply with any statute,
                law, ordinance, rule, regulation, order or decree of any of its
                subsidiaries and/or affiliates, or any of their respective business
                operations.

            

    

     

    
      	26.	
              Actions
                relating to the operations and management of the Company and/or its
                Subsidiaries.

            

    

     

    
      	27.	
              Actions
                taken in connection with the approval and execution of financial
                reports
                and business reports and the representations made in connection
                therewith.

            

    

     

    
      	
              28.

            	
              Any
                claim or demand, not covered by any of the categories of events described
                above, which, pursuant to any applicable law, a director or officer
                of the
                Company may be held liable to any government or agency thereof, or
                any
                person or entity, in connection with actions taken by such director
                or
                officer in such capacity.

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