Document:

EX-10.10

 Exhibit 10.10 

ADAPTIVE BIOTECHNOLOGIES CORPORATION 

INDEMNIFICATION AGREEMENT 

This Indemnification Agreement (the “Agreement”) is entered into on
                , 20    , between Adaptive Biotechnologies Corporation, a Washington corporation (the “Company”), and the
undersigned officer and/or director of the Company (“Indemnitee”), for good and valuable consideration as set forth below. 

RECITALS 

A.    The Company recognizes the importance, and increasing difficulty, of obtaining adequate liability insurance coverage
for its directors, officers, employees, agents and fiduciaries. 
 B.    The Company further recognizes that, at the
same time as the availability and coverage of such insurance has become more limited, litigation against corporate directors, officers, employees, agents and fiduciaries has continued to increase. 

C.    Section 5.4 of Article 5 of the Company’s Amended and Restated Articles of Incorporation (the
“Articles”) provides for indemnification of the Company’s directors and officers to the full extent authorized by the Washington Business Corporation Act (the “Statute”), and that such provisions
are not exclusive and may be supplemented by agreements between the Company and its directors, officers, employees and agents. 

D.    The Company desires to retain and attract the services of highly qualified individuals, such as Indemnitee, to serve
the Company and, in that connection, also desires to provide contractually for indemnification of, and advancement of expenses to, Indemnitee to the full extent authorized by law. 

AGREEMENT 

1.    Indemnification 

a.    Scope. The Company agrees to hold harmless and indemnify Indemnitee against any Damages (as defined in
Section 1(c)) incurred by Indemnitee with respect to any Proceeding (as defined in Section 1(d)) to which Indemnitee is or is threatened to be made a party or in which Indemnitee is otherwise involved (including, but not limited to, as a
witness), to the full extent authorized by law, without regard to the limitations in RCW 23B.08.510 through 23B.08.550, and 23B.08.560(2), except that Indemnitee shall have no right to indemnification on account of: (i) acts or omissions of
Indemnitee that have been finally adjudged (by a court having proper jurisdiction, and after all rights of appeal have been exhausted or lapsed, herein “Finally Adjudged”) to be intentional misconduct or a knowing violation
of law; (ii) conduct of Indemnitee that has been Finally Adjudged to be in violation of RCW 23B.08.310; (iii) any transaction with respect to which it has been Finally Adjudged that Indemnitee personally received a benefit in money,
property or services to which Indemnitee was not legally entitled; or (iv) any suit in which it is Finally Adjudged that Indemnitee is liable for 

  
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an accounting of profits made from the purchase or sale by Indemnitee of securities of the Company in violation of the provisions of Section 16(b) of the Securities Exchange Act of 1934 and
amendments thereto. 
 b.    Changes to Indemnification Right. Indemnitee’s right to be indemnified to the
full extent authorized by law shall include the benefits of any change, after the date of this Agreement, in the Statute or other applicable law regarding the right of a Washington corporation to indemnify directors, officers, employees or agents,
to the extent that it would expand Indemnitee’s rights hereunder. Any such change that would narrow or interfere with Indemnitee’s rights hereunder shall not apply to, limit, or affect the interpretation of, this Agreement, unless and then
only to the extent that it has been Finally Adjudged that its application hereto does not constitute an unconstitutional impairment of Indemnitee’s contract rights or otherwise violate applicable law. 

c.    Indemnified Amounts. If Indemnitee is or is threatened to be made a party to, or is otherwise involved
(including, but not limited to, as a witness) in, any Proceeding, the Company shall hold harmless and indemnify Indemnitee from and against any and all losses, claims, damages, costs, expenses and liabilities incurred in connection with
investigating, defending, being a witness in, participating in or otherwise being involved in (including on appeal), or preparing to defend, be a witness in, participate in or otherwise be involved in (including on appeal), such Proceeding,
including but not limited to attorneys’ fees, judgments, fines, penalties, ERISA excise taxes, amounts paid in settlement, any federal, state, local or foreign taxes imposed on Indemnitee as a result of the actual or deemed receipt of any
payments pursuant to this Agreement, and other expenses (collectively, “Damages”), including all interest, assessments or charges paid or payable in connection with or in respect of such Damages. 

d.    Definition of Proceeding. For purposes of this Agreement, “Proceeding” shall mean any
actual, pending, threatened or completed action, suit, claim, investigation, hearing or proceeding (whether civil, criminal, administrative or investigative, and whether formal or informal) in which Indemnitee is, has been or becomes involved, or
regarding which Indemnitee is threatened to be made a named defendant or respondent, based in whole or in part on or arising out of the fact that Indemnitee is or was a director, officer, member of a board committee, employee or agent of the Company
and/or any of its subsidiaries or that, being or having been such a director, officer, member of a board committee, employee or agent, Indemnitee is or was serving at the request of the Company as a director, officer, partner, employee,
trustee or agent of another corporation or of a foreign or domestic corporation, partnership, joint venture, trust, employee benefit plan or other enterprise (each, a “Related Company”), whether the basis of such action,
suit, claim, investigation, hearing or proceeding is alleged action or omission by Indemnitee in an official capacity as a director, officer, committee member, partner, employee, trustee or agent or in any other capacity while serving as a director,
officer, committee member, partner, employee, trustee or agent. “Proceeding” shall not, however, include any action, suit, claim, investigation, hearing or proceeding instituted by or at the direction of Indemnitee unless pursuant to an
Enforcement Action (as defined in Section 3(a)) or its institution has been authorized by the Company’s Board of Directors (the “Board”). 

  
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 e.    Notifications. 

i.    Promptly after receipt by Indemnitee of notice of the commencement (including a threatened assertion or
commencement) of any Proceeding, Indemnitee will, if it is reasonably foreseeable that a claim in respect thereof will be made against the Company under this Agreement, notify the Board of the commencement thereof (which notice shall be in the form
of attached Exhibit A) (the “Indemnification Notice”). A failure to notify the Company in accordance with this Section 1(e)(i) will not, however, relieve the Company from any liability to Indemnitee under this
Agreement unless (and then only to the extent that) such failure is Finally Adjudged to have materially prejudiced the Company’s ability to defend the Proceeding. 

ii.    At the same time, or from time to time thereafter, Indemnitee may further notify the Board, by delivery of a
supplemental Indemnification Notice (or by checking the second box and providing the corresponding information on the initial Indemnification Notice), of any Proceeding for which indemnification is being sought under this Agreement. 

f.    Determination of Entitlement. 

i.    To the extent Indemnitee has been wholly successful, on the merits or otherwise, in the defense of any Proceeding,
the Company shall indemnify Indemnitee against all expenses incurred by Indemnitee in connection with the Proceeding, within ten (10) days after receipt of an Indemnification Notice delivered pursuant to subsection (e)(ii). 

ii.    In the event that subsection (f)(i) above is inapplicable, or does not apply to the entire Proceeding, the Company
shall indemnify Indemnitee within thirty (30) days after receipt of an Indemnification Notice delivered pursuant to subsection (e)(ii) unless during such thirty (30) day period the Board delivers to Indemnitee a written notice contesting
Indemnitee’s indemnification claim (the “Contest Notice”), which Contest Notice shall state with particularity the reasons for the decision to challenge Indemnitee’s indemnification claim and the evidence the
Company would present in any forum in which Indemnitee might seek review of such decision. The Company’s failure to deliver a Contest Notice within thirty (30) days after the Company’s receipt of an Indemnification Notice pursuant to
subsection (e)(ii) shall obligate the Company unconditionally to indemnify Indemnitee to the extent requested in the Indemnification Notice. 

iii.    At any time following receipt of a Contest Notice, Indemnitee shall be entitled to select a forum for the review
of, and in which the Company will defend, the Contest Notice and the Company’s decision to challenge Indemnitee’s indemnification claim. Such selection shall be made from among the following alternatives, by delivering a written notice to
the Board indicating Indemnitee’s selection of forum: 
 (A)    A quorum of the Board consisting of directors who
are not parties to the Proceeding for which indemnification is being sought; 
 (B)    Special Legal Counsel (as
defined in Section 1(f)(vii)); or 

  
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 (C)    A panel of three independent arbitrators, one of whom is
selected by the Company, another of whom is selected by Indemnitee and the last of whom is selected by the first two arbitrators so selected, provided, that nothing in this Section 1(f) shall prevent Indemnitee at any time from
bringing suit against the Company to recover the amount of the indemnification claim (whether or not Indemnitee has otherwise exhausted its contractual remedies hereunder). In addition, any determination by a forum selected by Indemnitee that
Indemnitee is not entitled to indemnification, or any failure to make the payments requested in the Indemnification Notice, shall be subject to judicial review by any court of competent jurisdiction, as described in Section 3. 

iv.    In any forum in which the Company defends its Contest Notice and its decision to challenge Indemnitee’s
indemnification claim under this Section 1(f), the presumptions, burdens and standard of review set forth in Section 3(c) shall apply and are incorporated into this Section 1(f) by reference, except as otherwise expressly provided in
Section 3(c). 
 v.    As soon as practicable, and in no event later than fifteen (15) days after the forum
has been selected pursuant to subsection (f)(iii) above, the Company shall, at its own expense, submit the defense of its Contest Notice and the question of Indemnitee’s right to indemnification to the selected forum. 

vi.    The forum selected shall render its decision concerning the validity of the Contest Notice and the Company’s
decision to deny Indemnitee’s indemnification claim within thirty (30) days after the forum has been selected in accordance with Section 1(f)(iii). 

vii.    For the purposes of this Agreement, “Special Legal Counsel” shall mean an attorney or
firm of attorneys, selected by Indemnitee and approved by the Company (which approval shall not be unreasonably withheld), who must not have performed other services for the Company or Indemnitee within the last three years. 

2.    Expense Advances 

a.    Generally. The right to indemnification conferred by Section 1 shall include the right to have the
Company pay Indemnitee’s attorneys’ fees and other expenses, including but not limited to out of pocket costs and disbursements, incurred in connection with any Proceeding, or in connection with bringing, defending and/or pursuing an
Enforcement Action (as defined in Section 3(a)), as such expenses are incurred and in advance of the final disposition of such Proceeding or Enforcement Action (such entitlement is referred to hereinafter as an “Expense
Advance”). 
 b.    Undertaking. The Company’s obligation to provide an Expense Advance is
subject only to the following condition: Indemnitee or his or her representative must have executed and delivered to the Board an undertaking (in the form of attached Exhibit B) (the “Statement of Undertaking”) to
repay all Expense Advances if and to the extent that it may be Finally Adjudged that Indemnitee is not entitled to be indemnified for such Expense Advance under one or more of clauses (i) through (iv) of the first sentence of Section 1(a).
The Statement of Undertaking need not be secured and shall be accepted by the Company without reference to Indemnitee’s financial ability to make repayment. No interest shall be charged on any obligation to reimburse the Company for any Expense
Advance. 

  
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 c.    Service as Witness. Notwithstanding any other provision of
this Agreement, the Company’s obligation to indemnify, or provide Expense Advances under Section 2, to Indemnitee in connection with Indemnitee’s appearance as a witness in a Proceeding at a time when Indemnitee has not been made a
named defendant or respondent to the Proceeding shall be absolute and unconditional, and not subject to any of the limitations on, or conditions to, Indemnitee’s right to indemnification or to receive an Expense Advance otherwise contained in
this Agreement. 
 3.    Procedures for Enforcement 

a.    Enforcement. If a claim for indemnification made by Indemnitee hereunder is not paid in full (whether or not
the provisions of Section 1(f) have been complied with, or completed), or a claim for an Expense Advance made by Indemnitee hereunder is not paid in full within twenty (20) days from delivery of a Statement of Undertaking to the Board,
Indemnitee may, but need not, at any time thereafter bring suit against the Company to recover the unpaid amount of the claim (an “Enforcement Action”). 

b.    Required Indemnification. The court hearing the Enforcement Action shall order the Company to provide
indemnification or to advance expenses to Indemnitee to the full extent sought in the Enforcement Action if it determines that (i) the Enforcement Action is brought by Indemnitee to enforce the Company’s obligation under
Section 1(f)(ii) unconditionally to indemnify Indemnitee to the extent requested in the Indemnification Notice where the Company has failed timely to deliver a Contest Notice, or (ii) the Company failed to prove by clear and convincing
evidence that Indemnitee is not entitled to indemnification based on one or more of clauses (i) through (iv) of the first sentence of Section 1(a). 

c.    Presumptions, Burdens and Standard of Review in Enforcement Action or Company Determination. In any
Enforcement Action (and, except as otherwise expressly provided in this Section 3(c), in any review of a Contest Notice by a forum described in Section 1(f)) the following presumptions (and limitations on presumptions), burdens and
standard of review shall apply: 
 i.    The Company shall conclusively be presumed to have entered into this Agreement
and assumed the obligations imposed hereunder in order to induce Indemnitee to serve or to continue to serve as a director, officer, member of a board committee, employee and/or agent of the Company and/or one or more of its subsidiaries; 

ii.    This Agreement shall conclusively be presumed to be valid and Article 5 of the Articles shall conclusively be
presumed to be effective to waive all of the limitations in RCW 23B.08.510 through RCW 23B.08.550, and RCW 23B.08.560(2); 

iii.    Submission of an Indemnification Notice in accordance with Section 1(e)(ii) or a Statement of Undertaking to
the Company shall create a presumption that Indemnitee is entitled to indemnification or an Expense Advance hereunder, and thereafter the Company shall have the burden of proving by clear and convincing evidence (sufficient to rebut the foregoing
presumption) that Indemnitee is not entitled to indemnification based on one or more of clauses (i) through (iv) of the first sentence of Section 1(a); 

  
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 iv.    Indemnitee may establish a conclusive presumption of any
objective fact related to an event or occurrence by delivering to the Company a declaration made under penalty of perjury that such fact is true, provided, that no such presumption may be established with respect to the ultimate conclusions
set forth in any of clauses (i) through (iv) of the first sentence of Section 1(a); 
 v.    If Indemnitee is
or was serving as a director, officer, employee, trustee or agent of a corporation of which a majority of the shares entitled to vote in the election of its directors is held by the Company or in an executive or management capacity in a partnership,
joint venture, trust or other enterprise of which the Company or a wholly-owned subsidiary of the Company is a general partner or has a majority ownership, then such corporation, partnership, joint venture, trust or enterprise shall conclusively be
deemed a Related Company and Indemnitee shall conclusively be deemed to be serving such Related Company at the request of the Company; 

vi.    Neither (i) the failure of the Company (including but not limited to the Board, the Company’s officers,
independent counsel, Special Legal Counsel, any arbitrator or the Company’s shareholders) to make a determination prior to the commencement of the Enforcement Action whether indemnification, or payment of an Expense Advance, of Indemnitee is
proper in the circumstances nor (i) an actual determination by the Company, the Board, the Company’s officers, independent counsel, Special Legal Counsel, any arbitrator or the Company’s shareholders that Indemnitee is not entitled to
indemnification or payment of an Expense Advance shall be a defense to the Enforcement Action, create a presumption that Indemnitee is not entitled to indemnification hereunder or be considered by a court in an Enforcement Action, which shall
conduct a de novo review of the relevant issues; 
 vii.    The termination of any Proceeding by judgment, order,
settlement (whether with or without court approval) or conviction, or upon a plea of nolo contendere, or its equivalent, shall not create a presumption that Indemnitee did not meet any particular standard of conduct or have a particular belief or
that a court has determined that indemnification is not permitted under this Agreement or applicable law; and 

viii.    If the court hearing the Enforcement Action is unable to make either of the determinations specified in Sections
3(b)(i) or 3(b)(ii), the court hearing the Enforcement Action shall nonetheless order the Company to provide indemnification or to advance expenses to Indemnitee to the full extent sought in the Enforcement Action if it determines that Indemnitee is
fairly and reasonably entitled to such indemnification or Expense Advance in view of all of the relevant circumstances, and without regard to the limitations set forth in clauses (i) through (iii) of the first sentence of Section 1(a). In
determining whether Indemnitee is fairly and reasonably entitled to such indemnification or expense advance, the court shall weigh (i) the relative benefits received by the Company and/or any of its subsidiaries or any Related
Company, or any of their affiliates other than Indemnitee, on the one hand, and Indemnitee on the other from the transaction from which such Proceeding arose or to which such Proceeding relates, and (ii) the relative fault of the Company and/or
any of its subsidiaries or any 

  
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Related Company, or any of their affiliates other than Indemnitee, on the one hand, and of Indemnitee on the other in connection with the transaction that resulted in such Damages, as well as any
other relevant equitable considerations. The relative fault of the Company and/or any of its subsidiaries or any Related Company, or any of their affiliates other than Indemnitee, on the one hand, and of Indemnitee on the other shall be determined
by reference to, among other things, the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent the circumstances resulting in such Damages. If either (i) the relative benefits received by the
Company and/or any of its subsidiaries or any Related Company, or any of their affiliates other than Indemnitee, exceed the relative benefits received by Indemnitee, or (ii) the relative fault of the Company and/or any of its subsidiaries or
any Related Company, or any of their affiliates other than Indemnitee, exceeds the relative fault of Indemnitee, then Indemnitee shall be entitled to the full amount of indemnification and/or Expense Advance sought in the Enforcement Proceeding.

 d.    Attorneys’ Fees and Expenses for Enforcement Action. In any Enforcement Action, the Company shall
hold harmless and indemnify Indemnitee against all of Indemnitee’s attorneys’ fees and expenses in bringing, defending and/or pursuing the Enforcement Action (including but not limited to attorneys’ fees at any stage, and on appeal);
provided, however, that the Company shall not be required to provide such indemnification for such fees and expenses if it is Finally Adjudged that Indemnitee knew prior to commencement of the Enforcement Action that Indemnitee was not
entitled to indemnification based on any of clauses (i) through (iv) of the first sentence of Section 1(a). 

4.    Defense of Claim 

With respect to any Proceeding as to which Indemnitee has provided notice to the Company pursuant to Section 1(e)(i): 

a.    The Company may participate therein at its own expense. 

b.    The Company (jointly with any other indemnifying party similarly notified, if any) may assume the defense thereof,
with counsel reasonably satisfactory to Indemnitee. After notice from the Company to Indemnitee of its election to so assume the defense thereof, the Company shall not be liable to Indemnitee under this Agreement for any legal fees or other expenses
(other than reasonable costs of investigation and costs and expenses as participating as a witness) subsequently incurred by Indemnitee in connection with the defense thereof unless (i) the employment of counsel by Indemnitee or the incurring
of such expenses has been authorized by the Company, (ii) Indemnitee shall have concluded that there is a reasonable possibility that a conflict of interest could arise between the Company and Indemnitee in the conduct of the defense of such
Proceeding, which conflict of interest shall be conclusively presumed to exist upon Indemnitee’s delivery to the Company of a written certification of such conclusion, (iii) the Company shall not in fact have employed counsel to assume the
defense of such Proceeding or (iv) the Company does not continue to retain such counsel to defend such Proceeding, in each of which cases the legal fees and other expenses of Indemnitee shall be at the expense of the Company. The Company shall
not be entitled to assume the defense of a Proceeding brought by or on behalf of the Company or as to which Indemnitee shall have reached the conclusion described in clause (ii) above. 

  
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 c.    The Company shall not be liable for any amounts paid in settlement
of any Proceeding effected without its written consent. 
 d.    The Company shall not settle any Proceeding in any
manner that (i) would impose any penalty or limitation on Indemnitee, (ii) constitute any admission of wrongdoing of Indemnitee, or (iii) may compromise or adversely affect the defense of the Indemnitee in any other Proceeding, in
each case without Indemnitee’s written consent. 
 e.    Neither the Company nor Indemnitee will unreasonably
withhold its or his or her consent to any proposed settlement of any Proceeding. 
 5.    Maintenance of D&O
Insurance 
 a.    Subject to Section 5(c) below, during the period (the “Coverage
Period”) beginning on the date of this Agreement and ending at the later of (i) six (6) years following the time Indemnitee is no longer serving as a director, officer, member of a board committee, employee or agent of the Company
and/or one or more subsidiaries or any Related Company, or (ii) at the end of such longer period during which Indemnitee believes that a reasonable possibility of exposure to a Proceeding or Damages persists (which extended period must be
consented to by the Company, such consent not to be unreasonably withheld), the Company shall maintain a directors’ and officers’ liability insurance policy in full force and effect or shall have purchased or otherwise provided for a run-off or tail policy or endorsement to such existing policy (“D&O Insurance”), providing in all respects coverage at least comparable to and in similar amounts, and with similar
exclusions, as that obtained by other similarly situated companies as determined in good faith by any of the parties referenced in Section 1(f)(iii)(a) through (c). 

b.    Under all policies of D&O Insurance, Indemnitee shall during the Coverage Period be named as an insured in such
a manner as to provide Indemnitee the same rights and benefits, subject to the same limitations, as are accorded to the Company’s directors or officers most favorably insured by such policy, and each insurer under a policy of D&O Insurance
shall be required to provide Indemnitee written notice at least thirty (30) days prior to the effective date of termination of the policy. 

c.    Unless otherwise expressly provided in a written agreement between the Company and Indemnitee, the Company shall
have no obligation to obtain or maintain D&O Insurance to the extent that such insurance is not reasonably available, the premium costs for such insurance are disproportionate to the amount of coverage provided, or the coverage provided by such
insurance is so limited by exclusions as to provide an insufficient benefit, such determination to be made by any of the parties referenced in Section 1(f)(iii)(a) through (c). 

d.    It is the intention of the parties in entering into this Agreement that the insurers under the D&O Insurance, if
any, shall be obligated ultimately to pay any claims by Indemnitee which are covered by D&O Insurance, and nothing herein shall be deemed to diminish or otherwise restrict the Company’s or Indemnitee’s right to proceed or collect
against any insurers under D&O Insurance or to give such insurers any rights against the Company or Indemnitee under or with respect to this Agreement, including but not limited to any right to be

  
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subrogated to the Company’s or Indemnitee’s rights hereunder, unless otherwise expressly agreed to by the Company and Indemnitee in writing. The obligation of such insurers to the
Company and Indemnitee shall not be deemed reduced or impaired in any respect by virtue of the provisions of this Agreement. 

e.    Subject to Section 7, the Company shall not provide indemnification pursuant to this Agreement for Damages or
Expense Advances that have been paid directly to Indemnitee by an insurance carrier under a policy of D&O Insurance or other insurance maintained by the Company. 

f.    Subject to Section 7, in the event of payment under this Agreement, the Company shall be subrogated to the
extent of such payment to all of the rights of Indemnitee to recover the same amounts from any insurer or other third person (other than another person with indemnification rights against the Company substantially similar those of Indemnitee under
this Agreement). Indemnitee shall execute all documents required and take all acts necessary to secure such rights and enable the Company effectively to bring suit to enforce such rights. 

6.    Partial Indemnification; Mutual Acknowledgment; Contribution 

a.    Partial Indemnification. If Indemnitee is entitled under any provision of this Agreement to indemnification
by the Company for some or a portion of any Damages in connection with a Proceeding, but not for the total amount thereof, the Company shall nevertheless indemnify Indemnitee for the portion of such Damages to which Indemnitee is entitled. 

b.    Mutual Acknowledgment. The Company and Indemnitee acknowledge that, in certain instances, federal law or
public policy may override applicable state law and prohibit the Company from indemnifying Indemnitee under this Agreement or otherwise. For example, the Company and Indemnitee acknowledge that the Securities and Exchange Commission (the
“SEC”) has taken the position that indemnification is not permissible for liabilities arising under certain federal securities laws, and federal legislation prohibits indemnification for certain ERISA violations. Furthermore,
Indemnitee understands that the Company has undertaken or may be required in the future to undertake with the SEC to submit for judicial determination the issue of the Company’s power to indemnify Indemnitee in certain circumstances; all of the
Company’s obligations under this Agreement will be subject to the requirements of any such undertaking required by the SEC to be made by the Company. 

c.    Contribution. If the indemnification provided under Sections 1, 2 and 6 is unavailable by reason of any of
the circumstances specified in one or more of clauses (i) through (iii) of the first sentence of Section 1(a) then, in respect of any Proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such
Proceeding), the Company shall contribute to the amount of Damages (including attorneys’ fees) actually and reasonably incurred and paid or payable by Indemnitee in such proportion as is appropriate to reflect (i) the relative benefits
received by the Company and/or any of its subsidiaries or any Related Company, or any of their affiliates other than Indemnitee, on the one hand, and Indemnitee on the other from the transaction or events from which such Proceeding arose or to which
such Proceeding relates, and (ii) the relative fault of the Company and/or any of its 

  
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subsidiaries or any Related Company, or any of their affiliates other than Indemnitee, on the one hand, and of Indemnitee on the other in connection with the transaction or events that resulted
in such Damages, as well as any other relevant equitable considerations. The relative fault of the Company and/or any of its subsidiaries or any Related Company, or any of their affiliates other than Indemnitee, on the one hand, and of Indemnitee on
the other shall be determined by reference to, among other things, the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent the circumstances resulting in such Damages. The Company agrees that it
would not be just and equitable if contribution pursuant to this Section 6(c) were determined by pro rata allocation or any other method of allocation that does not take account of the foregoing equitable considerations. 

7.    Primacy of Indemnification 

The Company hereby acknowledges that the Indemnitee may have certain rights to indemnification, advancement of expenses or liability insurance
provided by a third-party and certain of its affiliates, other than the Company, any Related Company or the insurer under a D&O Insurance policy of the Company or any Related Company (collectively, the “Entity
Indemnitors”). The Company hereby agrees that the Company shall, and to the extent applicable shall cause each Related Company to, (i) be the indemnitor of first resort, i.e., its obligations to Indemnitee under this Agreement
(including, without limitation, indemnification for Damages and the obligation to make Expense Advances) and any indemnity provisions set forth in its Certificate of Incorporation, By-laws or elsewhere
(collectively, “Indemnity Arrangements”) are primary and (ii) advance the full amount of expenses incurred by the Indemnitee and shall be liable for the full amount of all expenses, judgments, penalties, fines and
amounts paid in settlement by or on behalf of the Indemnitee, to the extent legally permitted and as required by any Indemnity Arrangement, without regard to any rights the Indemnitee may have against the Entity Indemnitors. The Company hereby
irrevocably waives, relinquishes and releases, and shall cause each Related Company to irrevocably waive, relinquish and release, the Entity Indemnitors from any claims against the Entity Indemnitors for contribution, subrogation or any other
recovery of any kind arising out of or relating to any Indemnity Arrangement. The Company further agrees that no advancement or indemnification payment by any Entity Indemnitor on behalf of the Indemnitee shall affect the foregoing. Additionally,
the Entity Indemnitors shall be subrogated to the extent of such advancement or payment to all of the rights of recovery of the Indemnitee against the Company. In the event that any Entity Indemnitor makes a payment to the Indemnitee in respect of
indemnification or advancement of expenses where the Company or a Related Company is the indemnitor of first resort, the Company shall, and to the extent applicable shall cause the Related Companies to, promptly and fully reimburse the Entity
Indemnitor making such payment upon written demand by the Entity Indemnitor . The Company and the Indemnitee agree that the Entity Indemnitors are express third party beneficiaries of the terms of this Section 7, entitled to enforce this
Section 7 as though each such Entity Indemnitor were a party to this Agreement. The Company shall cause each of the Related Companies to perform the terms and obligations of this Section 7 as though each such Related Company was a party to
this Agreement 

  
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 8.    Miscellaneous 

a.    This Agreement shall be interpreted and enforced in accordance with the laws of the State of Washington. 

b.    This Agreement shall be binding upon Indemnitee and upon the Company, its successors and assigns, and shall inure to
the benefit of Indemnitee, Indemnitee’s heirs, personal representatives and assigns and to the benefit of the Company, its successors and assigns. The Company shall require any successor to the Company (whether direct or indirect, by purchase,
merger, consolidation or otherwise) to all or substantially all of the business or assets of the Company, expressly to assume and agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform
if no such succession had taken place. 
 c.    Indemnitee’s rights to indemnification and advancement of expenses
under this Agreement shall not be deemed exclusive of any other or additional rights to which Indemnitee may be entitled under the Articles or the Bylaws of the Company, any vote of shareholders or disinterested directors, the Statute or otherwise,
whether as to actions or omissions in Indemnitee’s official capacity or otherwise. 
 d.    Nothing in this
Agreement shall confer upon Indemnitee the right to continue to serve as a director, officer, member of a Board committee, employee and/or agent of the Company or any of its subsidiaries or any Related Company. If Indemnitee is an officer or
employee of the Company, then, unless otherwise expressly provided in a written employment agreement between the Company and Indemnitee, the employment of Indemnitee with the Company shall be terminable at will by either party. The indemnification
and release provided under this Agreement shall apply to any and all Proceedings, notwithstanding that Indemnitee has ceased to be a director, officer, partner, employee, trustee or agent of the Company, any of its subsidiaries or a Related Company,
and shall inure to the benefit of the heirs, executors and administrators of Indemnitee. 
 e.    If any provision or
provisions of this Agreement shall be held to be invalid, illegal or unenforceable for any reason whatsoever, then: (i) the validity, legality and enforceability of the remaining provisions of this Agreement (including, without limitation, all
portions of any paragraphs of this Agreement containing any such invalid, illegal or unenforceable provision that are not themselves invalid, illegal or unenforceable) shall not in any way be affected or impaired thereby; and (ii) to the
fullest extent possible, the provisions of this Agreement (including, without limitation, all portions of any paragraphs of this Agreement containing any such invalid, illegal or unenforceable provision, that are not themselves invalid, illegal or
unenforceable) shall be construed so as to give effect to the intent manifested by the provision held invalid, illegal or unenforceable. 

f.    Any notices or communications to be given or required to be given under this Agreement shall be given by personal
delivery, registered mail, overnight courier, facsimile or electronic mail at the following address or at the address following Indemnitee’s signature below. 

  
 11 

 Company: 

Adaptive Biotechnologies Corporation 

1551 Eastlake Ave. E, #200 

Seattle, WA 98102 

Attn: Legal Department 

Electronic mail: 
 Notices and
communications shall be deemed received by the addressee on the date of delivery if delivered in person, on the third (3rd) day after mailing if delivered by registered airmail, on the next business day after mailing if sent by overnight courier, on
the next business day if sent by telex or facsimile, or upon confirmation of delivery when directed to the electronic mail address described above if sent by electronic mail. 

g.    No amendment, modification, termination or cancellation of this Agreement shall be effective unless in writing
signed by both parties hereto. 
 h.    If Indemnitee has previously executed an indemnification agreement with the
Company, this Agreement supersedes such prior indemnification agreement in its entirety. 
 i.    This Agreement may be
executed in two counterparts, each of which shall be deemed an original, but both of which together shall constitute one and the same instrument. 

[Signature page to follow.] 

  
 12 

 IN WITNESS WHEREOF, the parties have executed and delivered this Agreement effective as of
the day and year first set forth above. 
  

							
	 “Company”
	 		 	 ADAPTIVE BIOTECHNOLOGIES CORPORATION

				
		 		 	By:	 	  

		 		 	Name:	 	Chad Robins
		 		 	Its:	 	Chief Executive Officer
			
	 “Indemnitee”
	 		 	
				
		 		 	Print Name:	 	  

		 		 	Address:	 	  

		 		 		 	  

		 		 	Fax:	 	  

		 		 	Telephone:	 	  

		 		 	Email:	 	  

  
 13 

 EXHIBIT A 

INDEMNIFICATION NOTICE 

Check the appropriate space below, and provide a brief description of the Proceeding as requested below: 

 

	 	☐	 Notice is hereby given by the undersigned,
                                         
                   , pursuant to Section 1(e)(i) of the Indemnification Agreement (the “Agreement”) dated
                    between Adaptive Biotechnologies Corporation, a Washington corporation (the “Company”), and the
undersigned, of the commencement of a Proceeding, as defined in the Agreement. A brief description of the Proceeding is as follows: 

  

	 	☐	 If indemnification of particular Damages (as defined in the Agreement) is being sought at this time, pursuant
to Section 1(e)(ii) of the Agreement, the undersigned hereby requests indemnification by the Company under the terms of the Agreement with respect to the following Damages incurred in connection with the Proceeding: 

Dated:                     ,
            . 
  

	
	
	 
	    [Signature of Indemnitee]

  

	
	
	 
	    [Print name]

 EXHIBIT B 

STATEMENT OF UNDERTAKING 
 STATE
OF                             ) 

      ) ss. 

COUNTY
OF                         ) 

I,
                            , being first duly sworn, do depose and say as follows: 

1.    This Statement is submitted pursuant to the Indemnification Agreement (the “Agreement”) dated
                         between Adaptive Biotechnologies Corporation, a Washington corporation (the
“Company”), and me. 
 2.    I am requesting an Expense Advance, as defined in the Agreement.

 3.    I hereby undertake to repay the Expense Advance if and to the extent it is Finally Adjudged (as defined in the
Agreement) that I am not entitled under the Agreement to be indemnified by the Company. 
 4.    The expenses for which
advancement is requested, and a brief description of the underlying Proceeding (as defined in the Agreement), are as follows: [Add brief description of expenses and Proceeding] 

 

							
	DATED:                     ,
            	 		 		 	  

		 		 		 	[Signature]

 SUBSCRIBED AND SWORN TO before me this         day of
                        . 
  

							
	(Seal or stamp)	 		 		 	  

		 		 		 	Notary Signature
				
		 		 		 	  

		 		 		 	 Print/Type Name
 Notary Public in and for the
State of
Washington,
residing at                                    
                                         
                         

									
		 		 		 	My appointment expiresEX-10.12

 Exhibit 10.12 

LEASE AGREEMENT 
 THIS
LEASE AGREEMENT (this “Lease”) is made this 21 day of July, 2011, between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE
TCR CORPORATION, a Washington corporation (“Tenant”). 
  

			
	Address:	 	1551 Eastlake Avenue, Seattle, Washington
		
	Premises:	 	That portion of the second floor of the Project, containing approximately 7,724 rentable square feet, as determined by Landlord, as shown on Exhibit A, subject to adjustment as provided in Section 5.
		
	Project:	 	The real property on which the building (the “Building”) in which the Premises are located, together with all improvements thereon and appurtenances thereto as described on Exhibit B.
		
	Base Rent:	 	$20,400.00 per month, subject to adjustment as provided in Section 4.
	
	
Rentable Area of Premises: 7,724 sq. ft.,
subject to adjustment as provided in Section 5.

	
	Rentable Area of Project: 115,738 sq. ft.
	
	Tenant’s Share of Operating Expenses: 6.67%, subject to adjustment as provided in Section 5.
		
	Security Deposit: $61,200.00	 	 Target Commencement Date: February 1, 2012

	
	Rent Adjustment Percentage: 2.5%
		
	Base Term:	 	Beginning on the Commencement Date and ending 64 months from the first day of the first full month after the Rent Commencement Date.
		
	Permitted Use:	 	Biomedical laboratory, related office and other related uses consistent with the character of the Project and otherwise in compliance with the provisions of Section 7 hereof.
		
	 Address for Rent Payment:
	 	 Landlord’s Notice Address:

	 P.O. Box 975383
	 	 385 E. Colorado Boulevard, Suite 299

	 Dallas, TX 75397-5383
	 	 Pasadena, CA 91101

		 	 Attention: Corporate Secretary

 Tenant’s Notice Address After Commencement Date: 

1551 Eastlake Avenue 
 Seattle, Washington 98102 

Attention: Lease Administrator 
 Tenant Notice Address Prior
to Commencement Date: 
 307 Westlake Avenue N 
 Suite 300

 Seattle, WA 98109 
 The following Exhibits and Addenda are
attached hereto and incorporated herein by this reference: 
 ☒ EXHIBIT A - PREMISES DESCRIPTION    
 ☒ EXHIBIT B - DESCRIPTION OF PROJECT 
 ☒ EXHIBIT C - WORK LETTER
                       ☒ EXHIBIT D - COMMENCEMENT DATE 

☒ EXHIBIT E - RULES AND REGULATIONS ☒ EXHIBIT F - TENANT’S PERSONAL PROPERTY 

  
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 ☒ EXHIBIT G - ASBESTOS DISCLOSURE ☒ EXHIBIT H -
EXPANSION PREMISES ☒ EXHIBIT I SPACE PLANS 
 1.    Lease of Premises. Upon and
subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to Tenant and Tenant hereby leases the Premises from Landlord. The portions of the Project which are for the non-exclusive
use of tenants of the Project are collectively referred to herein as the “Common Areas.” Landlord reserves the right to modify Common Areas, provided that such modifications do not materially adversely affect Tenant’s use of
the Premises for the Permitted Use. Tenant acknowledges and agrees that (i) the roof deck to be located on a portion of the roof of the Building and the auditorium to be located on the first floor of the Building shall be part of the Common
Areas of the Building, (ii) the roof deck and the auditorium shall be available to all of the tenants of the Building on a first come, first served basis or, at Landlord’s option, a reservation basis, and (iii) Landlord shall not be
responsible for enforcing any party’s right to use the roof deck or the auditorium. Tenant shall use the roof deck and the auditorium in a manner that complies with all applicable Legal Requirements and any and all rules and regulations which
may be adopted by Landlord from time to time. 
 2.    Delivery; Acceptance of Premises; Commencement Date.
Landlord shall use reasonable efforts to deliver the Premises to Tenant on or before the Target Commencement Date, with Landlord’s Work, if any, Substantially Completed (“Delivery” or “Deliver”). If Landlord
fails to timely Deliver the Premises, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and this Lease shall not be void or voidable except as provided herein. Notwithstanding the foregoing, Base Rent payable with
respect to the Premises shall be abated 1 day for each day after the Target Commencement Date (as the same may be extended for Force Majeure delays and Tenant Delays) that Landlord fails to Deliver the Premises to Tenant. If Landlord does not
Deliver the Premises within 90 days of the Target Commencement Date for any reason other than Force Majeure Delays and Tenant Delays, this Lease may be terminated by Landlord or Tenant by written notice to the other, and if so terminated by either:
(a) the Security Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant, and (b) neither Landlord nor Tenant shall have
any further rights, duties or obligations under this Lease, except with respect to provisions which expressly survive termination of this Lease. As used herein, the terms “Landlord’s Work,” “Tenant Delays” and
“Substantially Completed” shall have the meanings set forth for such terms in the Work Letter. If neither Landlord nor Tenant elects to void this Lease within 7 business days of the lapse of such 90 day period, such right to void
this Lease shall be waived and this Lease shall remain in full force and effect. 
 The “Commencement Date” shall be the
earlier of: (i) the date Landlord Delivers the Premises to Tenant; or (ii) the date Landlord could have Delivered the Premises but for Tenant Delays; provided, however, that in no event shall the Commencement Date occur earlier than
February 1, 2012. The “Rent Commencement Date” shall be the date that is 4 months after the Commencement Date. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Commencement Date, the Rent
Commencement Date and the expiration date of the Term when such are established in the form of the “Acknowledgement of Commencement Date” attached to this Lease as Exhibit D; provided, however, Tenant’s failure to
execute and deliver such acknowledgment shall not affect Landlord’s rights hereunder. The “Term” of this Lease shall be the Base Term, as defined above on the first page of this Lease and any Extension Terms which Tenant may
elect pursuant to Section 40 hereof. 
 Except as set forth in this Lease and the Work Letter: (i) Tenant
shall accept the Premises in their condition as of the Commencement Date, subject to all applicable Legal Requirements (as defined in Section 7 hereof); (ii) Landlord shall have no obligation for any defects in the
Premises; and (iii) Tenant’s taking possession of the Premises shall be conclusive evidence that Tenant accepts the Premises and that the Premises were in good condition at the time possession was taken. 

Except as otherwise in this Lease, Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation
or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct 

  
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of Tenant’s business, and Tenant waives any implied warranty that the Premises or the Project are suitable for the Permitted Use. This Lease constitutes the complete agreement of Landlord
and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises, agreements, understandings and negotiations which are not contained herein. Landlord in executing this Lease does so in
reliance upon Tenant’s representations, warranties, acknowledgments and agreements contained herein. 

3.    Rent. 

(a)    Base Rent. Base Rent for the month in which the Rent Commencement Date occurs and the Security
Deposit shall be due and payable on delivery of an executed copy of this Lease to Landlord. Tenant shall pay to Landlord in advance, without demand, abatement, deduction or set-off, monthly installments of
Base Rent on or before the first day of each calendar month during the Term hereof after the Rent Commencement Date, in lawful money of the United States of America, at the office of Landlord for payment of Rent set forth above, or to such other
person or at such other place as Landlord may from time to time designate in writing. Payments of Base Rent for any fractional calendar month shall be prorated. The obligation of Tenant to pay Base Rent and other sums to Landlord and the obligations
of Landlord under this Lease are independent obligations. Tenant shall have no right at any time to abate, reduce, or set-off any Rent (as defined in Section 5) due hereunder except for any
abatement as may be expressly provided in this Lease. 
 (b)    Additional Rent. In addition to
Base Rent, Tenant agrees to pay to Landlord as additional rent (“Additional Rent”): (i) Tenant’s Share of “Operating Expenses” (as defined in Section 5), and (ii) any and all other amounts Tenant
assumes or agrees to pay under the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of
this Lease to be performed by Tenant, after any applicable notice and cure period. 
 4.    Base Rent
Adjustments. Base Rent shall be increased on each annual anniversary of the first day of the first full month during the Term of this Lease (each an “Adjustment Date”) by multiplying the Base Rent payable immediately before such
Adjustment Date by the Rent Adjustment Percentage and adding the resulting amount to the Base Rent payable immediately before such Adjustment Date. Base Rent, as so adjusted, shall thereafter be due as provided herein. Base Rent adjustments for any
fractional calendar month shall be prorated. 
 5.    Operating Expense Payments. Landlord shall deliver to
Tenant a written estimate of Operating Expenses for each calendar year during the Term (the “Annual Estimate”), which may be revised by Landlord from time to time during such calendar year upon not less than 30 days’ written
notice to Tenant. Commencing on the Rent Commencement Date and continuing on the first day of each month thereafter during the Term, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for any
fractional calendar month shall be prorated. 
 The term “Operating Expenses” means all costs and expenses of any kind or
description whatsoever incurred or accrued each calendar year by Landlord with respect to the Project (including, without duplication, Taxes (as defined in Section 9), reasonable reserves consistent with good business practice for future
repairs and replacements, provided that the reserves collected shall not increase by more than 3% per year, capital repairs and improvements amortized over the lesser of 7 years and the useful life of such capital items, and the costs of
Landlord’s third party property manager or, if there is no third party property manager, administration rent in the amount of 5.0% of Base Rent), excluding only: 

(a)    the original construction costs of the Project and renovation prior to the date of the Lease and costs of
correcting defects in such original construction or renovation; 
 (b)    capital expenditures for expansion of the
Project; 

  
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 (c)    interest, principal payments of Mortgage (as defined in
Section 27) debts of Landlord, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured; 

(d)    depreciation of the Project (except for capital improvements, the cost of which are includable in Operating
Expenses); 
 (e)    advertising, legal and space planning expenses and leasing commissions and other costs and expenses
incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants; 

(f)    legal and other expenses incurred in the negotiation or enforcement of leases; 

(g)    completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or
performs for other tenants within their premises, and costs of correcting defects in such work; 
 (h)    costs to be
reimbursed by other tenants of the Project or Taxes to be paid directly by Tenant or other tenants of the Project, whether or not actually paid; 

(i)    salaries, wages, benefits and other compensation paid to officers and employees of Landlord who are not assigned in
whole or in part to the operation, management, maintenance or repair of the Project; 
 (j)    general organizational,
administrative and overhead costs relating to maintaining Landlord’s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(k)    costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in
connection with disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents,
purchasers or mortgagees of the Building; 
 (I)    costs incurred by Landlord due to the violation by Landlord, its
employees, agents or contractors or any tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 7); 

(m)    penalties, fines or interest incurred as a result of Landlord’s inability or failure to make payment of Taxes
and/or to file any tax or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(n)    overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or
services in or to the Project to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 

(o)    costs of Landlord’s charitable or political contributions, or of fine art maintained at the Project; 

(p)    costs in connection with services (including electricity), items or other benefits of a type which are not standard
for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project, whether or not such other tenant or occupant is specifically charged therefor by Landlord;

 (q)    costs incurred in the sale or refinancing of the Project; 

  
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 (r)    net income taxes of Landlord or the owner of any interest in the
Project, franchise, capital stock, gift, estate or inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; 

(s)    any costs incurred to remove, study, test, remediate or otherwise related to the presence of Hazardous Materials in
or about the Building or the Project, which Hazardous Materials Tenant proves (i) existed prior to the Commencement Date, (ii) originated from any separately demised tenant space within the Project other than the Premises or
(iii) were not brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, the Project by Tenant or any Tenant Party (as herein defined); 

(t)    the cost of repairs or other work to the extent Landlord is actually reimbursed by insurance or condemnation
proceeds; and 
 (u)    any expenses otherwise includable within Operating Expenses to the extent actually reimbursed by
persons other than tenants of the Project under leases for space in the Project. 
 Within 90 days after the end of each calendar year (or
such longer period as may be reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual Operating Expenses for the
previous calendar year, and (b) the total of Tenant’s payments in respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of Operating Expenses for such
year, the excess shall be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of actual Operating Expenses for
such year Landlord shall pay the excess to Tenant within 30 days after delivery of such Annual Statement, except that after the expiration, or earlier termination of the Term or if Tenant is delinquent in its obligation to pay Rent, Landlord shall
pay the excess to Tenant after deducting all other amounts due Landlord. 
 The Annual Statement shall be final and binding upon Tenant
unless Tenant, within 90 days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 90 day period, Tenant reasonably and in
good faith questions or contests the accuracy of Landlord’s statement of Tenant’s Share of Operating Expenses, Landlord will provide Tenant with access to Landlord’s books and records relating to the operation of the Project and such
information as Landlord reasonably determines to be responsive to Tenant’s questions (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of
Tenant’s Share of Operating Expenses, then Tenant shall have the right to have an independent regionally recognized public accounting firm selected by Tenant, working pursuant to a fee arrangement other than a contingent fee (at Tenant’s
sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld or delayed), audit and/or review the Expense Information for the year in question (the “Independent Review”). The results of any such
Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the payments actually made by Tenant with respect to Operating Expenses for the calendar year in question exceeded Tenant’s Share of Operating
Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the excess to Tenant within 30 days after
delivery of such statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. If
the Independent Review shows that Tenant’s payments with respect to Operating Expenses for such calendar year were less than Tenant’s Share of Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord within 30
days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with respect to Operating Expenses by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review.
Operating Expenses for the calendar years in which Tenant’s obligation to share therein begins and ends shall be prorated. Notwithstanding anything set forth herein to the contrary, if the Project is not at least 90% occupied on average during
any year of the Term, Tenant’s Share of Operating Expenses for such year shall be computed as though the Project had been 90% occupied on average during such year. 

  
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 “Tenant’s Share” shall be the percentage set forth on the first page of
this Lease as Tenant’s Share as reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. Landlord may equitably increase Tenant’s Share for any item of expense or cost
reimbursable by Tenant that relates to a repair, replacement, or service that benefits only the Premises or only a portion of the Project that includes the Premises or that varies with occupancy or use. Base Rent, Tenant’s Share of Operating
Expenses and all other amounts payable by Tenant to Landlord hereunder are collectively referred to herein as “Rent.” 

6.    Security Deposit. Tenant shall deposit with Landlord, upon delivery of an executed copy of this Lease to
Landlord, a security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth on page 1 of this Lease, which Security Deposit shall be in the form of an unconditional
and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw upon it at any time from time to
time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution satisfactory to Landlord, and (v) redeemable by presentation of a sight draft in the state of
Landlord’s choice. If Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before the stated expiration date of any then current Letter of Credit, Landlord shall have
the right to draw the full amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit. The Security Deposit shall be held by Landlord as security for the performance of
Tenant’s obligations under this Lease. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default. Upon each occurrence of a Default (as defined in Section 20),
Landlord may use all or any part of the Security Deposit to pay delinquent payments due under this Lease, future rent damages, and the cost of any damage, injury, expense or liability caused by such Default, without prejudice to any other remedy
provided herein or provided by law. Landlord’s right to use the Security Deposit under this Section 6 includes the right to use the Security Deposit to pay future rent damages following the termination of this Lease pursuant to
Section 21(c) below. Upon any use of all or any portion of the Security Deposit, Tenant shall pay Landlord on demand the amount that will restore the Security Deposit to the amount set forth on Page 1 of this Lease. Tenant hereby waives
the provisions of any law, now or hereafter in force, which provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the
Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other loss or damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any officer, employee,
agent or invitee of Tenant. Upon bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for periods prior to the filing of such
proceedings. Upon any such use of all or any portion of the Security Deposit, Tenant shall, within 5 days after demand from Landlord, restore the Security Deposit to its original amount. If Tenant shall fully perform every provision of this Lease to
be performed by Tenant, the Security Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant (or, at Landlord’s option, to the
last assignee of Tenant’s interest hereunder) within 90 days after the expiration or earlier termination of this Lease. 
 If Landlord
transfers its interest in the Project or this Lease, Landlord shall either (a) transfer any Security Deposit then held by Landlord to a person or entity assuming Landlord’s obligations under this Section 6, or (b) return
to Tenant any Security Deposit then held by Landlord and remaining after the deductions permitted herein. Upon such transfer to such transferee or the return of the Security Deposit to Tenant, Landlord shall have no further obligation with respect
to the Security Deposit, and Tenant’s right to the return of the Security Deposit shall apply solely against Landlord’s transferee. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of
Tenant’s default. Landlord’s obligation respecting the Security Deposit is that of a debtor, not a trustee, and no interest shall accrue thereon. 

  
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 If, as of the expiration of the 36th
month of the Base Term (i) Tenant is not in Default of this Lease, and (iii) Tenant has not been in default of this Lease at any time during the Term (collectively, the “Reduction Requirement”), then the Security Deposit
shall be reduced to an amount equal to 1 month’s Base Rent as of the 37th month of the Base Term (the “Reduced Security Deposit”). If Tenant has met the Reduction Requirement
and delivers a written request to Landlord for such reduction of the Security Deposit, Landlord shall cooperate with Tenant, at no out-of-pocket cost, expense or
liability to Landlord, to reduce the Letter of Credit then held by Landlord to the amount of the Reduced Security Deposit. If the Security Deposit is reduced as provided herein, then from and after the date of such reduction, the “Security
Deposit” shall be deemed to be the Reduced Security Deposit, for all purposes of this Lease. 

7.    Use. The Premises shall be used solely for the Permitted Use set forth in the basic lease provisions on page
1 of this Lease, and in compliance with all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Premises, and to the use and occupancy thereof,
including, without limitation, the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto, “ADA”) (collectively, “Legal Requirements” and each, a
“Legal Requirement”). Tenant shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by any Governmental Authority (as defined in Section 9) having jurisdiction to be
a violation of a Legal Requirement. Tenant will not use or permit the Premises to be used for any purpose or in any manner that would void Tenant’s or Landlord’s insurance, increase the insurance risk, or cause the disallowance of any
sprinkler or other credits. Tenant shall not permit any part of the Premises to be used as a “place of public accommodation”, as defined in the ADA or any similar legal requirement. Tenant shall reimburse Landlord promptly upon demand for
any additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused by Tenant’s use and/or occupancy of the Premises. Tenant will use the Premises in
a careful, safe and proper manner and will not commit or permit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the Premises or obstruct or interfere with the rights of Landlord or other tenants
or occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful purpose. Tenant shall cause any equipment or
machinery to be installed in the Premises so as to reasonably prevent sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not place any machinery or equipment which will overload the
floor in or upon the Premises or transport or move such items in the Project elevators without the prior written consent of Landlord, which consent shall not be unreasonably withheld. Tenant shall not, without the prior written consent of Landlord,
use the Premises in any manner which will require ventilation, air exchange, heating, gas, steam, electricity or water beyond the existing capacity of the Project as proportionately allocated to the Premises based upon Tenant’s Share as usually
furnished for the Permitted Use. 
 Landlord shall, at Landlord’s sole cost and expense, be responsible for the compliance of the
Premises with Legal Requirements, including the ADA, as of the Commencement Date. Tenant, at its sole expense, shall make any alterations or modifications to the interior or the exterior of the Premises or the Project that are required by Legal
Requirements (including, without limitation, compliance of the Premises with the ADA) related to Tenant’s use or occupancy of the Premises. Notwithstanding any other provision herein to the contrary, Tenant shall be responsible for any and all
demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation, reasonable attorneys’ fees,
charges and disbursements and costs of suit) (collectively, “Claims”) arising out of or in connection with Tenant’s failure to comply with any Legal Requirements, and Tenant shall indemnify, defend, hold and save Landlord
harmless from and against any and all Claims arising out of or in connection with Tenant’s failure to comply with any Legal Requirements. 

8.    Holding Over. If, with Landlord’s express written consent, Tenant retains possession of the Premises
after the termination of the Term, (i) unless otherwise agreed in such written consent, such possession shall be subject to termination by Landlord at any time upon 30 days notice to Tenant, (ii) all of the other terms and provisions of
this Lease (including, without limitation, the adjustment of Base Rent 

  
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 pursuant to Section 4 hereof) shall remain in full force and effect (excluding any
expansion or renewal option or other similar right or option) during such holdover period, (iii) Tenant shall continue to pay Base Rent in the amount payable upon the date of the expiration or earlier termination of this Lease or such other
amount as Landlord may indicate, in Landlord’s sole and absolute discretion, in such written consent, and (iv) all other payments shall continue under the terms of this Lease. If Tenant remains in possession of the Premises after the
expiration or earlier termination of the Term without the express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Rent in effect
during the last 30 days of the Term, and (B) Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages. No holding over by Tenant, whether with
or without consent of Landlord, shall operate to extend this Lease except as otherwise expressly provided, and this Section 8 shall not be construed as consent for Tenant to retain possession of the Premises. Acceptance by
Landlord of Rent after the expiration of the Term or earlier termination of this Lease shall not result in a renewal or reinstatement of this Lease. 

9.    Taxes. Landlord shall pay, as part of Operating Expenses, all taxes, levies, fees, assessments and
governmental charges of any kind, existing as of the Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or other governmental authority or agency,
including, without limitation, quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or measured by or based, in whole or in part, on rent
payable to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square footage, assessed value or other measure or evaluation of any kind of the
Premises or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises or the Project, including parking, or (iv) assessed or imposed by, or at the direction of, or resulting from Legal
Requirements, or interpretations thereof, promulgated by any Governmental Authority, or (v) imposed as a license or other fee, charge, tax, or assessment on Landlord’s business or occupation of leasing space in the Project. Landlord may
contest by appropriate legal proceedings the amount, validity, or application of any Taxes or liens securing Taxes. Taxes shall not include any net income taxes imposed on Landlord except to the extent such net income taxes are in substitution for
any Taxes payable hereunder. If any such Tax is levied or assessed directly against Tenant, then Tenant shall be responsible for and shall pay the same at such times and in such manner as the taxing authority shall require. Tenant shall pay, prior
to delinquency, any and all Taxes levied or assessed against any personal property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on Tenant’s personal property or trade
fixtures are levied against Landlord or Landlord’s property, or if the assessed valuation of the Project is increased by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant and whether or
not affixed to the real property so as to become a part thereof, higher than the base valuation on which Landlord from time-to-time allocates Taxes to all tenants in the
Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed valuation shall be binding and conclusive, absent manifest error. The amount of any such payment by Landlord
shall constitute Additional Rent due from Tenant to Landlord immediately upon demand. 
 10.    Parking. Subject
to all matters of record, Force Majeure, a Taking (as defined in Section 19 below) and the exercise by Landlord of its rights hereunder, Tenant shall have the right, in common with other tenants of the Project pro rata in
accordance with the rentable area of the Premises and the rentable areas of the Project occupied by such other tenants, to park in the non-reserved parking areas serving the Building (provided, however, that
in no event shall Tenant be entitled to more than its pro rata share of any particular parking area serving the Building), as may be modified by Landlord from time to time, subject in each case to Landlord’s rules and regulations. As of the
Commencement Date, Tenant’s pro rata share of parking spaces shall be 2 spaces per 1,000 rentable square feet of the Premises (which is equal to 14 spaces). As of the date hereof, there are four separate parking areas for the Building:
(i) one parking area includes underground parking under the Building (“Underground Parking”); (ii) the second parking area includes above-ground parking adjacent to the Building (“Surface Parking”); (iii) the
third parking area is a surface parking lot located to the northeast of the Building (“Northeast Parking”), (iv) the fourth parking area is a surface parking lot approximately 2 blocks from 

  
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the Building (the “Off-Site Parking”). Tenant share of parking spaces (i.e., the 2 parking spaces per 1,000 rentable square feet of the
Premises) shall be allocated among the Underground Parking, Surface Parking, Northeast Parking and Offsite Parking as follows: 4 reserved parking spaces in the Underground Parking, 2 unreserved parking spaces in the Surface Parking, 0 parking spaces
in the Northeast Parking and 8 unreserved parking spaces in the Off-Site Parking. Landlord may allocate parking spaces among Tenant and other tenants in the Project pro rata as described above if Landlord
determines that such parking facilities are becoming crowded. Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including other tenants of the Project or for enforcing any such reservation of
parking spaces. 
 11.    Utilities, Services. Landlord shall provide, subject to the terms of this
Section 11, water, electricity, heat, light, power, sewer, and other utilities (including gas and fire sprinklers to the extent the Project is plumbed for such services), refuse and trash collection and janitorial services for the Common
Areas (collectively, “Utilities”). Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer
charges or other similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar charges thereon. Landlord may cause, at Tenant’s expense, any Utilities to be separately
metered or charged directly to Tenant by the provider. Tenant shall pay directly to the Utility provider, prior to delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant
shall pay, as part of Operating Expenses, its share of all charges for jointly metered Utilities based upon consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever other than
Landlord’s willful misconduct, shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use.

 12.    Alterations and Tenant’s Property. Any alterations, additions, or improvements made to the
Premises by or on behalf of Tenant, including additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but excluding installation, removal or realignment of furniture systems (other than removal of furniture systems
owned or paid for by Landlord) not involving any modifications to the structure or connections (other then by ordinary plugs or jacks) to Building Systems (as defined in Section 13) (“Alterations”) shall be subject to
Landlord’s prior written consent, which may be given or withheld in Landlord’s sole discretion if any such Alteration affects the structure or Building Systems and shall not be otherwise unreasonably withheld, conditioned or delayed.
Tenant may construct nonstructural Alterations in the Premises without Landlord’s prior approval if the aggregate cost of all such work in any 12 month period does not exceed $50,000 (a “Notice-Only Alteration”), provided
Tenant notifies Landlord in writing of such intended Notice-Only Alteration, and such notice shall be accompanied by plans, specifications, work contracts and such other information concerning the nature and cost of the Notice-Only Alteration as may
be reasonably requested by Landlord, which notice and accompanying materials shall be delivered to Landlord not less than 15 business days in advance of any proposed construction. If Landlord approves any Alterations, Landlord may impose such
conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s reasonable discretion. Any request for approval shall be in writing, delivered not less than
15 business days in advance of any proposed construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the alterations as may be reasonably requested by
Landlord, including the identities and mailing addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord
shall have no duty to ensure that such plans and specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements and with Legal
Requirements and shall implement at its sole cost and expense any alteration or modification required by Legal Requirements as a result of any Alterations. Tenant shall pay to Landlord, as Additional Rent, on demand an amount equal to 2.5% of all
charges incurred by Tenant or its contractors or agents in connection with any Alteration to cover Landlord’s overhead and expenses for plan review, coordination, scheduling and supervision. Before Tenant begins any Alteration, Landlord may
post on and about the Premises notices of non-responsibility pursuant to 

  
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applicable law. Tenant shall reimburse Landlord for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant or its contractors,
delays caused by such work, or inadequate cleanup. 
 Tenant shall furnish security or make other arrangements satisfactory to Landlord to
assure payment for the completion of all Alterations work free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and other coverage in amounts and
from an insurance company satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations, Tenant shall deliver to Landlord: (i) sworn statements
setting forth the names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for any such Alteration. 

Except for Removable Installations (as hereinafter defined), all Installations (as hereinafter defined) shall be and shall remain the property
of Landlord during the Term and following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term, and shall remain upon and be surrendered with the Premises as a part thereof. Notwithstanding
the foregoing, Landlord may, at the time its approval of any such Installation is requested, or at the time it receives notice of a Notice Only Alteration, notify Tenant that Landlord requires that Tenant remove such Installation upon the expiration
or earlier termination of the Term, in which event Tenant shall remove such installation in accordance with the immediately succeeding sentence. Upon the expiration or earlier termination of the Term, Tenant shall remove (i) all wires, cables
or similar equipment which Tenant has installed in the Premises or in the risers or plenums of the Building, (ii) any Installations for which Landlord has given Tenant notice of removal in accordance with the immediately preceding sentence, and
(iii) all of Tenant’s Property (as hereinafter defined), and Tenant shall restore and repair any damage caused by or occasioned as a result of such removal, including, without limitation, capping off all such connections behind the walls
of the Premises and repairing any holes. During any restoration period beyond the expiration or earlier termination of the Term, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. If Landlord is
requested by Tenant or any lender, lessor or other person or entity claiming an interest in any of Tenant’s Property to waive any lien Landlord may have against any of Tenant’s Property, and Landlord consents to such waiver, then Landlord
shall be entitled to be paid as administrative rent a fee of $1,000 per occurrence for its time and effort in preparing and negotiating such a waiver of lien. Notwithstanding anything to the contrary contained herein, in no event shall Tenant be
required to remove the Tenant Improvements at the expiration or earlier termination of the Term. 
 For purposes of this Lease, (x)
“Removable Installations” means any items listed on Exhibit F attached hereto and any items agreed by Landlord in writing to be included on Exhibit F in the future, (y) “Tenant’s Property” means
Removable Installations and, other than Installations, any personal property or equipment of Tenant that may be removed without material damage to the Premises, and (z) “Installations” means all property of any kind paid for with by
Landlord, all Alterations, all fixtures, and all partitions, hardware, built-in machinery, built-in casework and cabinets and other similar additions, equipment,
property and improvements built into the Premises so as to become an integral part of the Premises, including, without limitation, fume hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms, walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment, autoclaves, chillers, built-in plumbing, electrical and mechanical equipment and systems, and any power generator and transfer switch. 

13.    Landlord’s Repairs. Landlord, as an Operating Expense, shall maintain all of the structural, exterior,
parking and other Common Areas of the Project, including HVAC, plumbing, fire sprinklers, elevators and all other building systems serving the Premises and other portions of the Project (“Building Systems”), in good repair,
reasonable wear and tear and uninsured losses and damages caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (collectively, “Tenant Parties”) excluded. Losses and damages caused by
Tenant or any Tenant Party shall be repaired by Landlord, to the extent not covered by insurance, at Tenant’s sole cost and expense. Landlord reserves the right to stop Building Systems services when necessary (i) by reason of accident or

  
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emergency, or (ii) for planned repairs, alterations or improvements, which are, in the judgment of Landlord, desirable or necessary to be made, until said repairs, alterations or
improvements shall have been completed. Landlord shall have no responsibility or liability for failure to supply Building Systems services during any such period of interruption; provided, however, that Landlord shall, except in case
of emergency, make a commercially reasonable effort to give Tenant 24 hours advance notice of any planned stoppage of Building Systems services for routine maintenance, repairs, alterations or improvements. Tenant shall promptly give Landlord
written notice of any repair required by Landlord pursuant to this Section, after which Landlord shall make a commercially reasonable effort to effect such repair. Landlord shall not be liable for any failure to make any repairs or to perform any
maintenance unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for such repairs or maintenance. Tenant waives its rights under any state or local law to terminate this Lease or to make such
repairs at Landlord’s expense and agrees that the parties’ respective rights with respect to such matters shall be solely as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of
damage or destruction shall be controlled by Section 18. 
 14.    Tenant’s Repairs. Subject to
Section 13 hereof, Tenant, at its expense, shall repair, replace and maintain in good condition all portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows, interior walls, and
the interior side of demising walls. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give Tenant notice of such failure. If Tenant fails to commence cure of such failure within 10 days of
Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant within 10 days after demand therefor; provided, however, that if such failure by Tenant creates or
could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure from Tenant. Subject to Sections 17 and 18, Tenant shall bear the full uninsured cost of any
repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the Premises. 

15.    Mechanic’s Liens. Tenant shall discharge, by bond or otherwise, any mechanic’s lien filed against
the Premises or against the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant within 10 days after the filing thereof, at Tenant’s sole cost and shall otherwise keep the Premises and the
Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have the right, but not the obligation, to pay such claim or
post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant shall lease or finance the acquisition of office
equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code Financing Statement filed as a matter of public record by any
lessor or creditor of Tenant will upon its face or by exhibit thereto indicate that such Financing Statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the address of the Project be
furnished on the statement without qualifying language as to applicability of the lien only to removable personal property, located in an identified suite held by Tenant. 

16.    Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord harmless from and
against any and Claims for injury or death to persons or damage to property occurring within or about the Premises, arising directly or indirectly out of use or occupancy of the Premises or a breach or default by Tenant in the performance of any of
its obligations hereunder, except to the extent caused by the willful misconduct or gross negligence of Landlord. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without limitation,
loss of records kept within the Premises). Tenant further waives any and all Claims for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of
records). Landlord shall not be liable for any damages arising from any act, omission or neglect of any tenant in the Project or of any other third party. 

  
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 17.    Insurance. Landlord shall maintain all risk property and,
if applicable, sprinkler damage insurance covering the full replacement cost of the Project or such lesser coverage amount as Landlord may elect provided such coverage amount is not less than 90% of such full replacement cost. Landlord shall
further procure and maintain commercial general liability insurance with a single loss limit of not less than $2,000,000 for bodily injury and property damage with respect to the Project. Landlord may, but is not obligated to, maintain such other
insurance and additional coverages as it may deem necessary, including, but not limited to, flood, environmental hazard and earthquake, loss or failure of building equipment, errors and omissions, rental loss during the period of repair or
rebuilding, workers’ compensation insurance and fidelity bonds for employees employed to perform services and insurance for any improvements installed by Tenant or which are in addition to the standard improvements customarily furnished by
Landlord without regard to whether or not such are made a part of the Project. All such insurance shall be included as part of the Operating Expenses. The Project may be included in a blanket policy (in which case the cost of such insurance
allocable to the Project will be determined by Landlord based upon the insurer’s cost calculations). 
 Tenant, at its sole cost and
expense, shall maintain during the Term: special form or all risk property insurance with business interruption and extra expense coverage, covering the full replacement cost of all property and improvements installed or placed in the Premises by
Tenant at Tenant’s expense; workers’ compensation insurance with no less than the minimum limits required by law; employer’s liability insurance with such limits as required by law; and commercial general liability insurance, with a
minimum limit of not less than $2,000,000 per occurrence for bodily injury and property damage with respect to the Premises. The commercial general liability insurance policy shall name Alexandria Real Estate Equities, Inc., and Landlord, its
officers, directors, employees, managers, agents, invitees and contractors (collectively, “Landlord Parties”), as additional insureds; insure on an occurrence and not a claims-made basis; be issued by insurance companies which have
a rating of not less than policyholder rating of A and financial category rating of at least Class X in “Best’s Insurance Guide”; shall not be cancelable for nonpayment of premium unless 30 days prior written notice shall have
been given to Landlord from the insurer; contain a hostile fire endorsement and a contractual liability endorsement; and provide primary coverage to Landlord (any policy issued to Landlord providing duplicate or similar coverage shall be deemed
excess over Tenant’s policies). Copies of such policies (if requested by Landlord), or certificates of insurance showing the limits of coverage required hereunder and showing Landlord as an additional insured, along with reasonable evidence of
the payment of premiums for the applicable period, shall be delivered to Landlord by Tenant upon commencement of the Term and upon each renewal of said insurance. Tenant’s policy may be a “blanket policy” with an aggregate per
location endorsement which specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least 5 days prior to the expiration of such policies, furnish Landlord with renewal
certificates. 
 In each instance where insurance is to name Landlord as an additional insured, Tenant shall upon written request of
Landlord also designate and furnish certificates so evidencing Landlord as additional insured to: (i) any lender of Landlord holding a security interest in the Project or any portion thereof, (ii) the landlord under any lease wherein
Landlord is tenant of the real property on which the Project is located, if the interest of Landlord is or shall become that of a tenant under a ground or other underlying lease rather than that of a fee owner, and/or (iii) any management
company retained by Landlord to manage the Project. 
 The property insurance obtained by Landlord and Tenant shall include a waiver of
subrogation by the insurers and all rights based upon an assignment from its insured, against Landlord or Tenant, and their respective officers, directors, employees, managers, agents, invitees and contractors (“Related Parties”),
in connection with any loss or damage thereby insured against. Neither party nor its respective Related Parties shall be liable to the other for loss or damage caused by any risk insured against under property insurance required to be maintained
hereunder, and each party waives any claims against the other party, and its respective Related Parties, for such loss or damage. The failure of a party to insure its property shall not void this waiver. Landlord and its respective Related Parties
shall not be liable for, and Tenant hereby waives all claims against such parties for, business interruption and losses occasioned thereby sustained by Tenant or any person claiming through Tenant resulting from any

  
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accident or occurrence in or upon the Premises or the Project from any cause whatsoever. If the foregoing waivers shall contravene any law with respect to exculpatory agreements, the liability of
Landlord or Tenant shall be deemed not released but shall be secondary to the other’s insurer. 
 Landlord may require insurance policy
limits to be raised to conform with requirements of Landlord’s lender and/or to bring coverage limits to levels then being generally required of new tenants within the Project. 

18.    Restoration. If, at any time during the Term, the Project or the Premises are damaged or destroyed by a fire
or other insured casualty, Landlord shall notify Tenant within 60 days after discovery of such damage as to the amount of time Landlord reasonably estimates it will take to restore the Project or the Premises, as applicable (the “Restoration
Period”). If the Restoration Period is estimated to exceed 12 months (the “Maximum Restoration Period”), Landlord may, in such notice, elect to terminate this Lease as of the date that is 75 days after the date of discovery
of such damage or destruction; provided, however, that notwithstanding Landlord’s election to restore, Tenant may elect to terminate this Lease by written notice to Landlord delivered within 10 business days of receipt of a notice
from Landlord estimating a Restoration Period for the Premises longer than the Maximum Restoration Period. Unless either Landlord or Tenant so elects to terminate this Lease, Landlord shall, subject to receipt of sufficient insurance proceeds (with
any deductible to be treated as a current Operating Expense), promptly restore the Premises (excluding the improvements installed by Tenant or by Landlord and paid for by Tenant), subject to delays arising from the collection of insurance proceeds,
from Force Majeure events or as needed to obtain any license, clearance or other authorization of any kind required to enter into and restore the Premises issued by any Governmental Authority having jurisdiction over the use, storage, handling,
treatment, generation, release, disposal, removal or remediation of Hazardous Materials (as defined in Section 30) in, on or about the Premises (collectively referred to herein as “Hazardous Materials Clearances”);
provided, however, that if repair or restoration of the Premises is not substantially complete as of the end of the Maximum Restoration Period or, if longer, the Restoration Period, Landlord may, in its sole and absolute discretion,
elect not to proceed with such repair and restoration, in which event Landlord shall be relieved of its obligation to make such repairs or restoration and this Lease shall terminate as of the date that is 75 days after the later of:
(i) discovery of such damage or destruction, or (ii) the date all required Hazardous Materials Clearances are obtained, but Landlord shall retain any Rent paid and the right to any Rent payable by Tenant prior to such election by Landlord
or Tenant. 
 Tenant, at its expense, shall promptly perform, subject to delays arising from the collection of insurance proceeds, from
Force Majeure (as defined in Section 34) events or to obtain Hazardous Material Clearances, all repairs or restoration not required to be done by Landlord and shall promptly re-enter the Premises and commence doing business in accordance
with this Lease. Notwithstanding the foregoing, either Landlord or Tenant may terminate this Lease upon written notice to the other if the Premises are damaged during the last year of the Term and Landlord reasonably estimates that it will take more
than 2 months to repair such damage; provided, however, that such notice is delivered within 10 business days after the date that Landlord provides Tenant with written notice of the estimated Restoration Period. Landlord shall also have the right to
terminate this Lease if insurance proceeds are not available for such restoration. Rent shall be abated from the date all required Hazardous Material Clearances are obtained until the Premises are repaired and restored, in the proportion which the
area of the Premises, if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant with other space during the period of repair that is suitable for the temporary conduct of Tenant’s business.
Such abatement shall be the sole remedy of Tenant, and except as provided in this Section 18, Tenant waives any right to terminate the Lease by reason of damage or casualty loss. 

The provisions of this Lease, including this Section 18, constitute an express agreement between Landlord and Tenant with respect
to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any damage or
destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section 18 sets forth their entire understanding and agreement with respect to such
matters. 

  
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 19.    Condemnation. If the whole or any material part of the
Premises or the Project is taken for any public or quasi-public use under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a “Taking” or “Taken”),
and the Taking would in Landlord’s reasonable judgment, either prevent or materially interfere with Tenant’s use of the Premises or materially interfere with or impair Landlord’s ownership or operation of the Project, then upon
written notice by Landlord this Lease shall terminate and Rent shall be apportioned as of said date. If part of the Premises shall be Taken, and this Lease is not terminated as provided above, Landlord shall promptly restore the Premises and the
Project as nearly as is commercially reasonable under the circumstances to their condition prior to such partial Taking and the rentable square footage of the Building, the rentable square footage of the Premises, Tenant’s Share of Operating
Expenses and the Rent payable hereunder during the unexpired Term shall be reduced to such extent as may be fair and reasonable under the circumstances. Upon any such Taking, Landlord shall be entitled to receive the entire price or award from any
such Taking without any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award. Tenant shall have the right, to the extent that same shall not diminish Landlord’s award, to make a separate claim
against the condemning authority (but not Landlord) for such compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures, if a separate award for such items is made to Tenant.
Tenant hereby waives any and all rights it might otherwise have pursuant to any provision of state law to terminate this Lease upon a partial Taking of the Premises or the Project. 

20.    Events of Default. Each of the following events shall be a default (“Default”) by Tenant
under this Lease: 
 (a)    Payment Defaults. Tenant shall fail to pay any installment of Rent or
any other payment hereunder when due; provided, however, that Landlord will give Tenant notice and an opportunity to cure any failure to pay Rent within 3 days of any such notice not more than once in any 12 month period. 

(b)    Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be
canceled or terminated or shall expire or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance before the expiration of the current
coverage. 
 (c)    Abandonment. Tenant shall abandon the Premises. 

(d)    Improper Transfer. Tenant shall assign, sublease or otherwise transfer or attempt to transfer
all or any portion of Tenant’s interest in this Lease or the Premises except as expressly permitted herein, or Tenant’s interest in this Lease shall be attached, executed upon, or otherwise judicially seized and such action is not released
within 90 days of the action. 
 (e)    Liens. Tenant shall fail to discharge or otherwise obtain
the release of any lien placed upon the Premises in violation of this Lease within 10 days after any such lien is filed against the Premises. 

(f)    Insolvency Events. Tenant or any guarantor or surety of Tenant’s obligations hereunder
shall: (A) make a general assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or
seeking reorganization, arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or of any substantial part of its
property (collectively a “Proceeding for Relief”); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor,
or surety is an individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

  
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 (g)    Estoppel Certificate or Subordination
Agreement. Tenant fails to execute any document required from Tenant under Sections 23 or 27 within 5 days after a second notice requesting such document. 

(h)    Other Defaults. Tenant shall fail to comply with any provision of this Lease other than those specifically
referred to in this Section 20, and, except as otherwise expressly provided herein, such failure shall continue for a period of 10 days after written notice thereof from Landlord to Tenant; provided that if the nature of
Tenant’s default pursuant to this Section 20(h) is such that it cannot be cured by the payment of money and reasonably requires more than 10 days to cure, then Tenant shall not be deemed to be in default if Tenant commences such cure
within said 10 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be completed no later than 60 days from the date of Landlord’s notice, as such time period may be extended for Force
Majeure delays 
 Any notice given under Section 20(h) hereof shall: (i) specify the alleged default, (ii) demand that
Tenant cure such default, (iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless Landlord
elects otherwise in such notice; provided that if the nature of Tenant’s default pursuant to Section 20(h) is such that it cannot be cured by the payment of money and reasonably requires more than 10 days to
cure, then Tenant shall not be deemed to be in default if Tenant commences such cure within said 10 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be completed no later than 60 days
from the date of Landlord’s notice. 
 21.    Landlord’s Remedies. 

(a)    Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without
waiving or releasing any obligation of Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to 12%
per annum or the highest rate permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing herein shall be construed to create or impose a duty on Landlord to mitigate
any damages resulting from Tenant’s Default hereunder. 
 (b)    Late Payment Rent. Late
payment by Tenant to Landlord of Rent and other sums due will cause Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited
to, processing and accounting charges and late charges which may be imposed on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such
payment is due, Tenant shall pay to Landlord an additional sum equal to 6% of the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late
payment by Tenant. In addition to the late charge, Rent not paid when due shall bear interest at the Default Rate from the 5th day after the date due until paid. 

(c)    Remedies. Upon the occurrence of a Default, Landlord, at its option, without further notice or
demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each and all of which shall be cumulative and nonexclusive,
without any notice or demand whatsoever. 
 (i)    Terminate this Lease, or at Landlord’s option,
Tenant’s right to possession only, in which event Tenant shall immediately surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may have for possession or 

  
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arrearages in rent, enter upon and take possession of the Premises and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof, without being liable for
prosecution or any claim or damages therefor; 
 (ii)    Upon any termination of this Lease, whether
pursuant to the foregoing Section 21(c)(i) or otherwise, Landlord may recover from Tenant the following: 

(A)    The worth at the time of award of any unpaid rent which has been earned at the time of such
termination; plus 
 (B)    The worth at the time of award of the amount by which the unpaid rent which
would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(C)    The worth at the time of award of the amount by which the unpaid rent for the balance of the Term
after the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(D)    Any other amount necessary to compensate Landlord for all the detriment proximately caused by
Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically including, but not limited to, brokerage commissions and advertising expenses incurred,
expenses of remodeling the Premises or any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain a new tenant; and 

(E)    At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be
permitted from time to time by applicable law. 
 The term “rent” as used in this Section 21 shall be deemed to
be and to mean all sums of every nature required to be paid by Tenant pursuant to the terms of this Lease, whether to Landlord or to others. As used in Sections 21(c)(ii)(A) and (B), above, the “worth at the time of
award” shall be computed by allowing interest at the Default Rate. As used in Section 21(c)(ii)(C) above, the “worth at the time of award” shall be computed by discounting such amount at the
discount rate of the Federal Reserve Bank of San Francisco at the time of award plus 1%. 

(iii)    Landlord may continue this Lease in effect after Tenant’s Default and recover rent as it
becomes due (Landlord and Tenant hereby agreeing that Tenant has the right to sublet or assign hereunder, subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this Lease following a Default by Tenant,
Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies hereunder, including the right to recover all Rent as it becomes due. 

(iv)    Whether or not Landlord elects to terminate this Lease following a Default by Tenant, Landlord
shall have the right to terminate any and all subleases, licenses, concessions or other consensual arrangements for possession entered into by Tenant and affecting the Premises or may, in Landlord’s sole discretion, succeed to Tenant’s
interest in such subleases, licenses, concessions or arrangements. Upon Landlord’s election to succeed to Tenant’s interest in any such subleases, licenses, concessions or arrangements, Tenant shall, as of the date of notice by Landlord of
such election, have no further right to or interest in the rent or other consideration receivable thereunder. 

(v)    Independent of the exercise of any other remedy of Landlord hereunder or under
applicable law, Landlord may conduct an environmental test of the Premises as generally described in Section 30(c) hereof, at Tenant’s expense. 

  
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 (d)    Effect of Exercise. Exercise by Landlord of any remedies
hereunder or otherwise available shall not be deemed to be an acceptance of surrender of the Premises and/or a termination of this Lease by Landlord, it being understood that such surrender and/or termination can be effected only by the express
written agreement of Landlord and Tenant. Any law, usage, or custom to the contrary notwithstanding, Landlord shall have the right at all times to enforce the provisions of this Lease in strict accordance with the terms hereof; and the failure of
Landlord at any time to enforce its rights under this Lease strictly in accordance with same shall not be construed as having created a custom in any way or manner contrary to the specific terms, provisions, and covenants of this Lease or as having
modified the same and shall not be deemed a waiver of Landlord’s right to enforce one or more of its rights in connection with any subsequent default. A receipt by Landlord of Rent or other payment with knowledge of the breach of any covenant
hereof shall not be deemed a waiver of such breach, and no waiver by Landlord of any provision of this Lease shall be deemed to have been made unless expressed in writing and signed by Landlord. To the greatest extent permitted by law, Tenant waives
the service of notice of Landlord’s intention to re-enter, re-take or otherwise obtain possession of the Premises as provided in any statute, or to institute legal
proceedings to that end, and also waives all right of redemption in case Tenant shall be dispossessed by a judgment or by warrant of any court or judge. Any reletting of the Premises or any portion thereof shall be on such terms and conditions as
Landlord in its sole discretion may determine. Landlord shall not be liable for, nor shall Tenant’s obligations hereunder be diminished because of, Landlord’s failure to relet the Premises or collect rent due in respect of such reletting
or otherwise to mitigate any damages arising by reason of Tenant’s Default. 
 22.    Assignment and
Subletting. 
 (a)    General Prohibition. Without Landlord’s prior written consent subject
to and on the conditions described in this Section 22, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or
hypothecate its leasehold interest or grant any concession or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. If Tenant is a corporation, partnership or limited liability company, the shares or
other ownership interests thereof which are not actively traded upon a stock exchange or in the over-the-counter market, a transfer or series of transfers whereby 50% or
more of the issued and outstanding shares or other ownership interests of such corporation are, or voting control is, transferred (but excepting transfers upon deaths of individual owners) from a person or persons or entity or entities which were
owners thereof at time of execution of this Lease to persons or entities who were not owners of shares or other ownership interests of the corporation, partnership or limited liability company at time of execution of this Lease, shall be deemed an
assignment of this Lease requiring the consent of Landlord as provided in this Section 22. 

(b)    Permitted Transfers. If Tenant desires to assign, sublease, hypothecate or otherwise transfer
this Lease or sublet the Premises, then at least 15 business days, but not more than 90 business days, before the date Tenant desires the assignment or sublease to be effective (the “Assignment Date”), Tenant shall give Landlord a
notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the proposed use of the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in
or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all material terms and conditions of the proposed assignment or sublease, including a copy of any proposed
assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration whether to grant its consent. Landlord may, by giving written notice to Tenant within 15 business days
after receipt of the Assignment Notice: (i) grant such consent, (ii) refuse such consent, in its reasonable discretion; or (iii) terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment
Date (an “Assignment Termination”). Among other reasons, it shall be reasonable for Landlord to withhold its consent in any of these instances: (1) the proposed assignee or subtenant is a governmental agency; (2) in
Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant would entail any alterations that would lessen the value of the leasehold improvements in the Premises, or would require increased services by
Landlord; (3) in Landlord’s good faith reasonable judgment, the proposed assignee or subtenant is engaged in areas of scientific research or other business concerns 

  
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that are controversial such that they may (i) attract or cause negative publicity for or about the Building or the Project, (ii) negatively affect the reputation of the Building, the
Project or Landlord, (iii) attract protestors to the Building or the Project, or (iv) lessen the attractiveness of the Building or the Project to any tenants or prospective tenants, purchasers or lenders; (4) in Landlord’s
reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment or sublease; (5) in Landlord’s reasonable judgment, the character,
reputation, or business of the proposed assignee or subtenant is inconsistent with the desired tenant-mix in that its use differs from the Permitted Use or the quality of other tenancies in the Project or is
inconsistent with the type and quality of the nature of the Building; (6) Landlord has received from any prior landlord to the proposed assignee or subtenant a negative report concerning such prior landlord’s experience with the proposed
assignee or subtenant; (7) Landlord has experienced previous defaults by or is in litigation with the proposed assignee or subtenant; (8) the use of the Premises by the proposed assignee or subtenant will violate any applicable Legal
Requirement; (9) the proposed assignee or subtenant, or any entity that, directly or indirectly, controls, is controlled by, or is under common control with the proposed assignee or subtenant, is then an occupant of the Project; (10) the
proposed assignee or subtenant is an entity with whom Landlord is negotiating to lease space in the Project; or (11) the assignment or sublease is prohibited by Landlord’s lender. If Landlord delivers notice of its election to exercise an
Assignment Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 7 business days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant
withdraws such Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to
the space described in such Assignment Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the
proposed assignment, sublease or other transfer. Tenant shall pay to Landlord a fee equal to One Thousand Five Hundred Dollars ($1,500) in connection with its consideration of any Assignment Notice and/or its preparation or review of any consent
documents. Notwithstanding the foregoing, Landlord’s consent to an assignment of this Lease or a subletting of any portion of the Premises to any entity controlling, controlled by or under common control with Tenant (a “Control
Permitted Assignment”) shall not be required, provided that Landlord shall have the right to approve the form of any such sublease or assignment. In addition, Tenant shall have the right to assign this Lease, upon 30 days prior written
notice to Landlord but without obtaining Landlord’s prior written consent, to a corporation or other entity which is a successor-in-interest to Tenant, by way of
merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant provided that (i) such merger or consolidation, or such acquisition or assumption, as the case
may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in accordance with generally accepted accounting principles (“GAAP”)) of the assignee
is not less than the greater of the net worth (as determined in accordance with GAAP) of Tenant as of (A) the Commencement Date, or (B) as of the date of Tenant’s most current quarterly or annual financial statements, and
(iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment (a “Corporate Permitted Assignment”). Control Permitted
Assignments and Corporate Permitted Assignments are hereinafter referred to as “Permitted Assignments.” 

(c)    Additional Conditions. As a condition to any such assignment or subletting, whether or not Landlord’s
consent is required, Landlord may require: 
 (i)    that any assignee or subtenant agree, in writing at
the time of such assignment or subletting, that if Landlord gives such party notice that Tenant is in default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received
by Landlord without any liability except to credit such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason;
provided, however, in no event shall Landlord or its successors or assigns be obligated to accept such attornment; and 

  
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 (ii)    A list of Hazardous Materials, certified by the
proposed assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents relating to such use,
storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without limitation: permits;
approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has
given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any
storage tanks installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s) of the such documents containing
information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 

(d)    No Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting,
Tenant and any guarantor or surety of Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for the payment of Rent and for compliance with all of Tenant’s other obligations under this
Lease. If the Rent due and payable by a sublessee or assignee (or a combination of the rental payable under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceed the sum of the rental
payable under this Lease, (excluding however, any Rent payable under this Section) and actual and reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms of any such sublease)
(“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the Premises or any part
thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the
occurrence of a Default, Tenant shall have the right to collect such rent. 
 (e)    No Waiver. The
consent by Landlord to an assignment or subletting shall not relieve Tenant or any assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant
or any assignee or sublessee of Tenant from full and primary liability under the Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not
be deemed to be a waiver of any of the provisions of this Lease or a consent to any subletting, assignment or other transfer of the Premises. 

(f)    Prior Conduct of Proposed Transferee. Notwithstanding any other provision of this
Section 22, if (i) the proposed assignee or sublessee of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a
property, where the contamination resulted from such party’s action or use of the property in question, (ii) the proposed assignee or sublessee is subject to an enforcement order issued by any Governmental Authority in connection with the
use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental Authority), or (iii) because of the
existence of a pre-existing environmental condition in the vicinity of or underlying the Project, the risk that Landlord would be targeted as a responsible party in connection with the remediation of such pre-existing environmental condition would be materially increased or exacerbated by the proposed use of Hazardous Materials by such proposed assignee or sublessee, Landlord shall have the absolute right to refuse
to consent to any assignment or subletting to any such party. 
 23.    Estoppel Certificate. Tenant shall,
within 10 business days of written notice from Landlord, execute, acknowledge and deliver a statement in writing in any form reasonably requested by a 

  
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proposed lender or purchaser, (i) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this
Lease as so modified is in full force and effect) and the dates to which the rental and other charges are paid in advance, if any, (ii) acknowledging that there are not any uncured defaults on the part of Landlord hereunder, or specifying such
defaults if any are claimed, and (iii) setting forth such further information with respect to the status of this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or
encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure to deliver such statement within such time shall, at the option of Landlord, constitute a Default under this Lease, and, in any event,
shall be conclusive upon Tenant that the Lease is in full force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. 

24.    Quiet Enjoyment. So long as Tenant is not in Default under this Lease, Tenant shall, subject to the terms of
this Lease, at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 

25.    Prorations. All prorations required or permitted to be made hereunder shall be made on the basis of a 360
day year and 30 day months. 
 26.    Rules and Regulations. Tenant shall, at all times during the Term and any
extension thereof, comply with all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as Exhibit E. If
there is any conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Landlord shall not have any liability or obligation for the breach of any rules or regulations by
other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 

27.    Subordination. This Lease and Tenant’s interest and rights hereunder are hereby made and shall be
subject and subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements, renewals, modifications, consolidations, refinancing, assignments and
extensions thereof, without the necessity of any further instrument or act on the part of Tenant; provided, however that so long as there is no Default hereunder, Tenant’s right to possession of the Premises shall not be disturbed
by the Holder of any such Mortgage. Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to any such Holder. Tenant agrees upon demand to execute, acknowledge and deliver such instruments, confirming such subordination, and
such instruments of attornment as shall be requested by any such Holder, provided any such instruments contain appropriate non-disturbance provisions assuring Tenant’s quiet enjoyment of the Premises as
set forth in Section 24 hereof. Notwithstanding the foregoing, any such Holder may at any time subordinate its Mortgage to this Lease, without Tenant’s consent, by notice in writing to Tenant, and thereupon this Lease
shall be deemed prior to such Mortgage without regard to their respective dates of execution, delivery or recording and in that event such Holder shall have the same rights with respect to this Lease as though this Lease had been executed prior to
the execution, delivery and recording of such Mortgage and had been assigned to such Holder, The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of trust, security assignments and any other encumbrances,
and any reference to the “Holder” of a Mortgage shall be deemed to include the beneficiary under a deed of trust. As of the date of this Lease, there is no existing Mortgage encumbering the Project. 

28.    Surrender. Upon the expiration of the Term or earlier termination of Tenant’s right of possession,
Tenant shall surrender the Premises to Landlord in the same condition as received, subject to any Alterations or Installations permitted by Landlord to remain in the Premises, free of Hazardous Materials brought upon, kept, used, stored, handled,
treated, generated in, or released or disposed of from, the Premises by any person other than a Landlord Party (collectively, “Tenant HazMat Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear
and tear and casualty loss and condemnation covered by Sections 18 and 19 excepted. At least 3 months prior to 

  
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the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any Governmental Authority) to be taken by Tenant in order to
surrender the Premises (including any Installations permitted by Landlord to remain in the Premises) at the expiration or earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for
unrestricted use and occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a current listing of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to
the Premises, and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with
the review and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat Operations
as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s
expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective date of such
surrender or early termination of the Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional Rent, for the actual out-of pocket expense incurred by
Landlord for Landlord’s environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify satisfactory completion of the same, which cost shall not exceed $5,000. Landlord shall have the unrestricted right
to deliver such Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. 

If Tenant shall fail to prepare or submit a Surrender Plan approved by Landlord, or if Tenant shall fail to complete the approved Surrender
Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about the Premises, Landlord shall have the right to take such actions as Landlord may
deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of which actions shall be reimbursed by Tenant as Additional Rent, without regard to the
limitation set forth in the first paragraph of this Section 28. 
 Tenant shall immediately return to Landlord all
keys and/or access cards to parking, the Project, restrooms or all or any portion of the Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either
the cost of replacing such lost access card or key or the cost of reprogramming the access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property
not so removed by Tenant as permitted or required herein shall be deemed abandoned and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from
Landlord’s retention and/or disposition of such property. All obligations of Tenant hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Section 30 hereof, shall
survive the expiration or earlier termination of the Term, including, without limitation, indemnity obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 

29.    Waiver of Jury Trial. TO THE EXTENT PERMITTED BY LAW, TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY
OR TO HAVE A JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION
HEREWITH OR THE TRANSACTIONS RELATED HERETO. 
 30.    Environmental Requirements. 

(a)    Prohibition/Compliance/Indemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter
defined) to be brought upon, kept, used, stored, handled, treated, generated in 

  
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or about, or released or disposed of from, the Premises or the Project in violation of applicable Environmental Requirements (as hereinafter defined) by Tenant or any Tenant Party. If Tenant
breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises during the Term or any holding over results in contamination of the Premises, the Project or any adjacent property or if
contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises by anyone other than Landlord and
Landlord’s employees, agents and contractors otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and contractors harmless from any and
all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages (including, without limitation,
punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without limitation, attorneys’,
consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether or not based upon personal
injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise during or after the Term as a
result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal, or restoration work required
by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials on the
Premises, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent property, Tenant shall promptly take all actions at its sole expense and in
accordance with applicable Environmental Requirements as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that Landlord’s approval of such
action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises or the Project. Notwithstanding anything to the
contrary contained in this Section 30, Tenant shall not be responsible for, and the indemnification and hold harmless obligation set forth in this paragraph shall not apply to (i) contamination in the Premises which Tenant can prove to
Landlord’s reasonable satisfaction existed in the Premises immediately prior to the Commencement Date, or (ii) the presence of any Hazardous Materials in the Premises which Tenant can prove to Landlord’s reasonable satisfaction
migrated from outside of the Premises into the Premises, unless in either case, the presence of such Hazardous Materials (x) is the result of a breach by Tenant of any of its obligations under this Lease, or (y) was caused, contributed to
or exacerbated by Tenant or any Tenant Party. 
 (b)    Business. Landlord acknowledges that it is not the intent
of this Section 30 to prohibit Tenant from using the Premises for the Permitted Use. Tenant may operate its business according to prudent industry practices so long as the use or presence of Hazardous Materials is strictly
and properly monitored according to all then applicable Environmental Requirements. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the
Commencement Date a list identifying each type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises and setting forth any and all governmental approvals or
permits required in connection with the presence, use, storage, handling, treatment, generation, release or disposal of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord
an updated Hazardous Materials List at least once a year and shall also deliver an updated list before any new Hazardous Material is brought onto, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises.
Tenant shall deliver to Landlord true and correct copies of the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to the
Commencement Date, or if unavailable at that time, concurrent with the receipt from or submission to a Governmental Authority: permits; approvals; reports and correspondence; storage and management plans, notice of violations of any Legal 

  
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Requirements; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has
given Tenant its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any
storage tanks installed in, on or under the Project for the closure of any such tanks; and a Surrender Plan (to the extent surrender in accordance with Section 28 cannot be accomplished in 3 months). Tenant is not required,
however, to provide Landlord with any portion(s) of the Haz Mat Documents containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. It is not the intent
of this Section to provide Landlord with information which could be detrimental to Tenant’s business should such information become possessed by Tenant’s competitors. 

(c)    Tenant Representation and Warranty. Tenant hereby represents and warrants to Landlord that
(i) neither Tenant nor any of its legal predecessors has been required by any prior landlord, lender or Governmental Authority at any time to take remedial action in connection with Hazardous Materials contaminating a property which
contamination was permitted by Tenant of such predecessor or resulted from Tenant’s or such predecessor’s action or use of the property in question, and (ii) Tenant is not subject to any enforcement order issued by any Governmental
Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental Authority).
If Landlord determines that this representation and warranty was not true as of the date of this lease, Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion. 

(d)    Testing. Landlord shall have the right to conduct annual tests of the Premises to determine
whether any contamination of the Premises or the Project has occurred as a result of Tenant’s use. Tenant shall be required to pay the cost of such annual test of the Premises; provided, however, that if Tenant conducts its own tests of the
Premises using third party contractors and test procedures acceptable to Landlord which tests are certified to Landlord, Landlord shall accept such tests in lieu of the annual tests to be paid for by Tenant. In addition, at any time, and from time
to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate tests of the Premises and the Project to determine if contamination has occurred as a result of Tenant’s use of the
Premises. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such non-proprietary information concerning the use of Hazardous Materials in or
about the Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section 30, Tenant shall pay all costs to conduct such tests. If no such contamination is found, Landlord
shall pay the costs of such tests (which shall not constitute an Operating Expense). Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of the Premises made by or
on behalf of Landlord during the Term without representation or warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental conditions identified by such
testing in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant. 

(e)    Control Areas, Tenant shall be allowed to utilize up to its pro rata share of the Hazardous
Materials inventory within any control area or zone (located within the Premises), as designated by the applicable building code, for chemical use or storage. As used in the preceding sentence, Tenant’s pro rata share of any control areas or
zones located within the Premises shall be determined based on the rentable square footage that Tenant leases within the applicable control area or zone. For purposes of example only, if a control area or zone contains 10,000 rentable square feet
and 2,000 rentable square feet of a tenant’s premises are located within such control area or zone (while such premises as a whole contains 5,000 rentable square feet), the applicable tenant’s pro rata share of such control area would be
20%. 
 (f)    Underground Tanks. If underground or other storage tanks storing Hazardous Materials
located on the Premises or the Project are used by Tenant or are hereafter placed on the Premises or the Project by Tenant, Tenant shall install, use, monitor, operate, maintain, upgrade and manage such 

  
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storage tanks, maintain appropriate records, obtain and maintain appropriate insurance, implement reporting procedures, properly close any underground storage tanks, and take or cause to be taken
all other actions necessary or required under applicable state and federal Legal Requirements, as such now exists or may hereafter be adopted or amended in connection with the installation, use, maintenance, management, operation, upgrading and
closure of such storage tanks. 
 (g)    Tenant’s Obligations. Tenant’s obligations under
this Section 30 shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to complete the removal
from the Premises of any Hazardous Materials (including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises and the completion of the approved Surrender Plan), Tenant shall continue to pay
the full Rent in accordance with this Lease for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 

(h)    Definitions. As used herein, the term “Environmental Requirements” means all
applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to health, safety, or environmental conditions on, under, or about the
Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource Conservation and Recovery Act; and all state and local counterparts
thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and includes any substance, material, waste, pollutant, or contaminant listed or defined as hazardous or
toxic, or regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied
natural gas, or synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s
“facility” and the “owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or
produced therefrom. 
 31.    Tenant’s Remedies/Limitation of Liability. Landlord shall not be in default
hereunder unless Landlord fails to perform any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will, due to the nature of the obligation, require a period of time in
excess of 30 days, then after such period of time as is reasonably necessary). Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage covering the Premises and to any landlord of any lease
of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by power of sale or a judicial action if such
should prove necessary to effect a cure; provided Landlord shall have furnished to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of Landlord hereunder shall be construed as
covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

All obligations of Landlord under this Lease will be binding upon Landlord only during the period of its ownership of the Premises and not
thereafter. The term “Landlord” in this Lease shall mean only the owner for the time being of the Premises. Upon the transfer by such owner of its interest in the Premises, such owner shall thereupon be released and discharged from
all obligations of Landlord thereafter accruing, but such obligations shall be binding during the Term upon each new owner for the duration of such owner’s ownership. 

32.    Inspection and Access. Landlord and its agents, representatives, and contractors may enter the Premises at
any reasonable time to inspect the Premises and to make such repairs as may be required or permitted pursuant to this Lease and for any other business purpose. Landlord and Landlord’s representatives may enter the Premises during business hours
on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required 
  

  
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and such entry may be at any time) for the purpose of effecting any such repairs, inspecting the Premises, showing the Premises to prospective purchasers and, during the last year of the Term, to
prospective tenants or for any other business purpose. Landlord may erect a suitable sign on the Premises stating the Premises are available to let or that the Project is available for sale. Landlord may grant easements, make public dedications,
designate Common Areas and create restrictions on or about the Project, provided that no such easement, dedication, designation or restriction materially, adversely affects Tenant’s use or occupancy of the Premises for the Permitted Use.
At Landlord’s request, Tenant shall execute such instruments as may be necessary for such easements, dedications or restrictions. Tenant shall at all times, except in the case of emergencies, have the right to escort Landlord or its agents,
representatives, contractors or guests while the same are in the Premises, provided such escort does not materially and adversely affect Landlord’s access rights hereunder. 

33.    Security. Tenant acknowledges and agrees that security devices and services, if any, while
intended to deter crime may not in given instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises. Tenant agrees that Landlord shall not be liable to Tenant for, and Tenant
waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of security with respect to the Premises. Tenant
shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the Premises and/or the Project. Tenant shall at Tenant’s cost obtain
insurance coverage to the extent Tenant desires protection against such criminal acts. 
 34.    Force
Majeure. Landlord shall not be responsible or liable for delays in the performance of its obligations hereunder when caused by, related to, or arising out of acts of God, sinkholes or subsidence, strikes, lockouts, or other labor disputes,
embargoes, quarantines, weather, national, regional, or local disasters, calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities
necessary for performance, governmental restrictions, orders, limitations, regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil
disturbance or commotion, fire or other casualty, and other causes or events beyond the reasonable control of Landlord (“Force Majeure”). 

35.    Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any
broker, agent or other person (collectively, “Broker”) in connection with this transaction and that no Broker brought about this transaction, other than CBRE. Landlord and Tenant each hereby agree to indemnify and hold the other
harmless from and against any claims by any Broker, other than the broker, if any named in this Section 35, claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as
applicable, with regard to this leasing transaction. 
 36.    Limitation on Landlord’s
Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT TO THE CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON ASSUME ALL
RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS,
LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL
RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER
SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE 

  
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PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST LANDLORD IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY
OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR
INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. 

37.    Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable
under present or future laws, then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. It is also the intention of the parties to this Lease that in lieu of each clause or
provision of this Lease that is illegal, invalid or unenforceable, there be added, as a part of this Lease, a clause or provision as similar in effect to such illegal, invalid or unenforceable clause or provision as shall be legal, valid and
enforceable. 
 38.    Signs; Exterior Appearance. Tenant shall not, without the prior written
consent of Landlord, which may be granted or withheld in Landlord’s sole discretion: (i) attach any awnings, exterior lights, decorations, balloons, flags, pennants, banners, painting or other projection to any outside wall of the Project,
(ii) use any curtains, blinds, shades or screens other than Landlord’s standard window coverings, (iii) coat or otherwise sunscreen the interior or exterior of any windows, (iv) place any bottles, parcels, or other articles on
the window sills, (v) place any equipment, furniture or other items of personal property on any exterior balcony, or (vi) paint, affix or exhibit on any part of the Premises or the Project any signs, notices, window or door lettering,
placards, decorations, or advertising media of any type which can be viewed from the exterior of the Premises. Interior signs on doors and the directory tablet shall be inscribed, painted or affixed for Tenant by Landlord at the sole cost and
expense of Tenant, and shall be of a size, color and type acceptable to Landlord. Notwithstanding the foregoing, Tenant shall have the right, at Tenant’s sole cost and expense, the paint or affix signage bearing Tenant’s name and logo on
its interior entrance door and window, provided that such signage shall be subject to Landlord’s reasonable approval and applicable Legal Requirements. Nothing may be placed on the exterior of corridor walls or corridor doors other than
Landlord’s standard lettering. The directory tablet shall be provided exclusively for the display of the name and location of tenants. 

Landlord intends to erect a monument sign at the Project, in a location acceptable to Landlord in its sole and absolute discretion, upon which
the names of tenants of the Project shall be displayed (“Monument Sign”), Tenant shall have the non-exclusive right, at Tenant’s sole cost and expense, to display Tenant’s name on
such Monument Sign. Tenant acknowledges and agrees that Tenant’s signage on the Monument Sign including, without limitation, the size, color and type, shall be subject to Landlord’s prior written approval, which shall not be unreasonably
withheld and shall be consistent with Landlord’s signage program at the Project and applicable Legal Requirements. Tenant shall be responsible, at Tenant’s sole cost and expense, for the maintenance of Tenant’s signage on the Monument
Sign, for the removal of Tenant’s signage on the Monument Sign at the expiration or earlier termination of this Lease and for the repair all damage resulting from such removal. 

39.    Right to Expand. 

(a)    Commencing on the first day of the 25th month of the Base Term
and no later than the expiration of the 36th month of the Base Term (the “Expansion Period”), Tenant shall have the right, but not the obligation, to expand the Premises (the
“Expansion Right”) to include the Expansion Space in the Building upon the terms and conditions contained in this Section. For purposes of this Section 39(a), “Expansion Space” shall mean that
certain approximately 3,000 rentable square feet of space, as shown on Exhibit H, if the same is not occupied by a tenant or which is occupied by an existing tenant whose lease is expiring within 6 months or less and such tenant does not wish
to renew (whether or not such tenant has a right to renew) its occupancy of such space. If Tenant elects to exercise its Expansion Right pursuant to this Section 39(a), Tenant shall deliver no less than 9 months and no more
than 12 months advance written notice to Landlord of such election (“Expansion Notice”), which Expansion Notice shall 

	 	

  
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be delivered no earlier than the last day of the 12th month of the Base Term and no later than the last day of the 24th month of the Base Term (“Election Period”). If Tenant elects to lease the Expansion Space by delivering the Expansion Notice within the Election Period, Tenant shall be deemed to
agree to lease the Expansion Space on the same terms and conditions as this Lease except that (i) the commencement date of the Lease with respect to the Expansion Space shall be date that Landlord delivers the Expansion Premises to Tenant for
Tenant’s construction of tenant improvements within the Expansion Space (“Expansion Space Commencement Date”); (ii) Tenant shall continue to pay Base Rent for the original Premises as provided for in this Lease and, in addition
thereto, commencing on the Expansion Space Commencement Date, Tenant shall pay Base Rent for the Expansion Space at the same per square foot Base Rent as the original Premises (as adjusted pursuant to Section 4); (iii) Tenant’s
Share of Operating Expenses shall be proportionately adjusted; (iv) the Security Deposit shall be increased by an amount equal to 3 months Base Rent for the Expansion Space (which amount shall be subject to reduction pursuant to the last
paragraph of Section 6); and (v) Landlord shall provide a tenant improvement allowance (“Expansion Space TI Allowance”) for the construction of tenant improvements within the Expansion Space of a fixed and permanent
nature desired by Tenant and approved by Landlord, which tenant improvements shall be treated as Alterations pursuant to Section 12, in an amount up to $2.00 per rentable square foot of the Expansion Space for each month
remaining in the Base Term of the Lease (for example, if the Expansion Space Commencement Date occurs with 34 months remaining in the Base Term, Landlord shall provide to Tenant a tenant improvement allowance equal to $68.00 per rentable square foot
of the Expansion Space ($2.00 multiplied by the 34 months remaining in the Base Term). Notwithstanding anything to the contrary contained herein, in no event shall the Work Letter apply to the Expansion Space. Tenant’s failure to deliver an
Expansion Notice to Landlord during the Election Period shall be deemed to be an election by Tenant not to exercise Tenant’s right to lease the Expansion Space in which case Tenant shall be deemed to have forever waived its right to lease the
Expansion Space and Landlord shall thereafter have the right to lease the Expansion Space to any third party on any terms and conditions acceptable to Landlord. 

(b)    Amended Lease. If: (i) Tenant fails to timely deliver an Expansion Notice within the Election Period,
or (ii) after the expiration of a period of 30 days from the date Tenant delivers the Election Notice, no lease amendment or lease agreement for the Expansion Space has been mutually executed, Tenant shall be deemed to have waived its right to
lease the Expansion Space. 
 (c)    Exceptions. Notwithstanding the above, the Expansion Right shall, at
Landlord’s option not be in effect and may not be exercised by Tenant: 
 (i)    during any period
of time that Tenant is in Default under any provision of the Lease; or 
 (ii)    if Tenant has been in
Default under any provision of the Lease 3 or more times, whether or not the Defaults are cured, during the 12 month period prior to the date on which Tenant seeks to exercise the Expansion Right. 

(d)    Termination. The Expansion Right shall, at Landlord’s option, terminate and be of no further force or
effect even after Tenant’s due and timely exercise of the Expansion Right, if, after such exercise, but prior to the commencement date of the lease of such Expansion Space, (i) Tenant fails to timely cure any default by Tenant under the
Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Expansion Right to the date of the commencement of the lease of the Expansion Space, whether or not such Defaults are cured. 

(e)    Rights Personal. Expansion Rights are personal to Tenant and are not assignable without Landlord’s
consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease, except that they may be assigned in connection with any Permitted
Assignment of this Lease. 

  
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 (f)    No Extensions. The period of time within
which any Expansion Rights may be exercised shall not be extended or enlarged by reason of Tenant’s inability to exercise the Expansion Rights. 

40.    Right to Extend Term. Tenant shall have the right to extend the Term of the Lease upon the following terms
and conditions: 
 (a)    Extension Rights. Tenant shall have 1 right (an “Extension
Right”) to extend the term of this Lease for 5 years (an “Extension Term”) on the same terms and conditions as this Lease (other than with respect to Base Rent) by giving Landlord written notice of its election to exercise
the Extension Right at least 9 months prior to the expiration of the Base Term of the Lease. 
 Upon the commencement of the Extension Term,
Base Rent shall be payable at the Market Rate (as defined below). Base Rent shall thereafter be adjusted on each annual anniversary of the commencement of such Extension Term by the Rent Adjustment Percentage. As used herein, “Market
Rate” shall mean the then market rental rate as determined by Landlord and agreed to by Tenant, which shall in no event be less than the Base Rent payable as of the date immediately preceding the commencement of such Extension Term
increased by the Rent Adjustment Percentage multiplied by such Base Rent. 
 If, on or before the date which is 180 days prior to the
expiration of the Base Term of this Lease, Tenant has not agreed with Landlord’s determination of the Market Rate during the Extension Term after negotiating in good faith, Tenant shall be deemed to have elected arbitration as described in
Section 40(b). Tenant acknowledges and agrees that, if Tenant has elected to exercise the Extension Right by delivering notice to Landlord as required in this Section 40(a), Tenant shall have no
right thereafter to rescind or elect not to extend the term of the Lease for the Extension Term. 

(b)    Arbitration. 

(i)    Within 10 days of Tenant’s notice to Landlord of its election (or deemed election) to arbitrate
Market Rate, each party shall deliver to the other a proposal containing the Market Rate that the submitting party believes to be correct (“Extension Proposal”). If either party fails to timely submit an Extension Proposal, the
other party’s submitted proposal shall determine the Base Rent for the first year of the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after delivery of the last Extension Proposal
and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate. If Landlord and Tenant are unable to agree upon a single Arbitrator, then each shall, by written notice delivered to the other
within 10 days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal shall determine the Base Rent for the first year of the Extension Term.
The 2 Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If the 2 Arbitrators so selected cannot agree on the selection of the third Arbitrator within the time above specified, then either
party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the Premises are located, upon 10 days prior written notice to the other
party of such intent. 
 (ii)    The decision of the Arbitrator(s) shall be made within 30 days after the
appointment of a single Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and
binding upon the parties. Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate for the first
year of the Extension Term is not determined by the first day of the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by the Rent Adjustment
Percentage until such 

  
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determination is made. After the determination of the Market Rate, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an
amendment recognizing the Market Rate for the Extension Term. 
 (iii)    An
“Arbitrator” shall be any person appointed by or on behalf of either party or appointed pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less
than 10 years of experience in the appraisal of improved office and high tech industrial real estate in the greater Seattle metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years experience
representing landlords and/or tenants in the leasing of high tech or life sciences space in the greater Seattle metropolitan area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the
time of appointment and (iii) be in all respects impartial and disinterested. 
 (c)    Rights
Personal. The Extension Right is personal to Tenant and is not assignable without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of
Tenant’s interest in the Lease, except that they may be assigned in connection with any Permitted Assignment of this Lease. 

(d)    Exceptions. Notwithstanding anything set forth above to the contrary, Extension Rights shall, at
Landlord’s option, not be in effect and Tenant may not exercise the Extension Right: 

(i)    during any period of time that Tenant is in Default under any provision of this Lease; or 

(ii)    if Tenant has been in Default under any provision of this Lease 3 or more times, whether or not the
Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults are cured. 

(e)    No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or
enlarged by reason of Tenant’s inability to exercise the Extension Right. 
 (f)    Termination. The
Extension Right, at Landlord’s option, shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension
Term, (i) Tenant fails to timely cure any default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the
Extension Term, whether or not such Defaults are cured. 
 41.    Right to Terminate. Only if Tenant has timely
and properly exercised its Expansion Notice in accordance with the terms of Section 39(a) and Landlord is required and does not deliver the Expansion Space to Tenant during the Expansion Period (“Expansion Failure
Delivery”), Tenant shall have the right to terminate this Lease (“Termination Right”) upon delivery of no less than 9 months advance written notice to Landlord (“Termination Notice”). Tenant’s
Termination Notice shall set forth the date upon which Tenant elects to terminate this Lease, which shall in no event be earlier than 9 months after Tenant’s delivery to Landlord of the Termination Notice (“Termination Date”).
If this Lease is terminated pursuant to this Section 41, then Tenant shall vacate the Premises and deliver possession thereof to Landlord in the condition required by the terms of this Lease on or before the Termination
Date, and Tenant shall have no further obligations under this Lease except for those accruing prior to the Termination Date, including the obligation to pay Rent through the Termination Date and those which, pursuant to the terms of the Lease,
survive the expiration or early termination of the Lease. Notwithstanding anything to the contrary contained herein, if Tenant fails to deliver a Termination Notice to Landlord within 30 days after an Expansion Failure Delivery, Tenant’s
Termination Right under this Section 41 shall immediately terminate and this Section 41 shall be of no further force and effect. 

  
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 42.    Intentionally Omitted. 

43.    Asbestos. 

(a)    Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials
(“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the Location identified in Exhibit G. 

(b)    Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (a) of this
Section 43 and understands that the purpose of such notification is to make Tenant and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order to
avoid or minimize any damage to or disturbance of such ACMs and/or PACMs. 
  

	
	CMR
	Tenant’s Initials

 (c)    Acknowledgement from Contractors/Employees. Tenant shall give Landlord at
least 14 days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify or
describe the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to
determine whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval. Upon Landlord’s
request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within or about the Premises in the
locations identified in Exhibit G prior to the commencement of such activities. Nothing in this Section 43 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct, authorize or
permit any such activities. 
 (i)    Removal of thermal system insulation (“TSI”) and
surfacing ACMs and PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 

(ii)    Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or 

(iii)    Repair and maintenance of operations that are likely to disturb ACMs or PACMs. 

44.    Miscellaneous. 

(a)    Notices. All notices or other communications between the parties shall be in writing and shall be deemed duly
given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty courier, addressed and sent to the parties at their addresses set forth above.
Landlord and Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 

(b)    Joint and Several Liability. If and when included within the term “Tenant,” as used in this
instrument, there is more than one person entity, each shall be jointly and severally liable for the obligations of Tenant. 

(c)    Financial Information. Tenant shall furnish Landlord with true and complete copies of (i) Tenant’s
most recent audited annual financial statements within 90 days of the end of each of Tenant’s fiscal years during the Term, (ii) Tenant’s most recent unaudited quarterly financial statements within 45 days of the end of each of
Tenant’s first three fiscal quarters of each of Tenant’s fiscal years during the Term, (iii) at Landlord’s request from time to time, but not more than once per year, updated business

  
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plans, including cash flow projections and/or pro forma balance sheets and income statements, all of which shall be treated by Landlord as confidential information belonging to Tenant,
(iv) corporate brochures and/or profiles prepared by Tenant for prospective investors, and (v) any other financial information or summaries that Tenant typically provides to its lenders or shareholders. 

(d)    Recordation. Neither this Lease nor a memorandum of lease shall be filed by or on behalf of
Tenant in any public record. Landlord may prepare and file, and upon request by Landlord Tenant will execute, a memorandum of lease. 

(e)    Interpretation. The normal rule of construction to the effect that any ambiguities are to be
resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. Words of any gender used in this Lease shall be held and construed to include any other gender, and words in the
singular number shall be held to include the plural, unless the context otherwise requires. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise describe the scope or intent of this Lease, or any
provision hereof, or in any way affect the interpretation of this Lease. 
 (f)    Not Binding Until
Executed. The submission by Landlord to Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party until execution
of this Lease by both parties. 
 (g)    Limitations on Interest. it is expressly the intent of
Landlord and Tenant at all times to comply with applicable law governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest
called for under this Lease, or contracted for, charged, taken, reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on
the applicable obligation (or, if the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without
the necessity of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 

(h)    Choice of Law. Construction and interpretation of this Lease shall be governed by the internal
laws of the state in which the Premises are located, excluding any principles of conflicts of laws. 

(i)    Time. Time is of the essence as to the performance of Tenant’s obligations under this
Lease. 
 (j)    OFAC. Tenant, and all beneficial owners of Tenant, are currently (a) in
compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or
regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List maintained by OFAC and/or on any
other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the
OFAC Rules. 
 (k)    Incorporation by Reference. All exhibits and addenda attached hereto are
hereby incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control. 

(l)    Entire Agreement. This Lease, including the exhibits attached hereto, constitutes the entire
agreement between Landlord and Tenant pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings, letters of intent, negotiations and discussions, whether oral or written, of the parties, and
there are no warranties, representations or other agreements, express or implied, made to either party by the other party in connection with the subject matter hereof except as specifically set forth herein. 

  
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 (m)    No Accord and Satisfaction. No payment by
Tenant or receipt by Landlord of a lesser amount than the monthly installment of Base Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any
check or letter accompanying a check for payment of any Base Rent or Additional Rent be an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue
any other remedy provided in this Lease. 
 (n)    Hazardous Activities. Notwithstanding any other
provision of this Lease, Landlord, for itself and its employees, agents and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to Tenant’s routine safety guidelines,
practices or custom or prudent industry practices, require any form of protective clothing or equipment other than safety glasses. in any such case, Tenant shall contract with parties who are acceptable to Landlord, in Landlord’s reasonable
discretion, for all such repairs and services, and Landlord shall, to the extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that Landlord is not providing such repairs or
services to Tenant. 
 [Signatures on next page] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year first
above written. 
  

							
	TENANT:	 		 	
	
	ADAPTIVE TCR CORPORATION,
	a Washington corporation
	By:	 	/s/ Chad Robins
	Its:	 	  
 President &
CEO

	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
	a Delaware limited liability company
		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
				
		 		 	By:	 	 /s/ Jackie Clem

		 		 	Its:	 	 VP Real Estate Legal Affairs

  
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 EXHIBIT B TO LEASE 

DESCRIPTION OF PROJECT 
 PARCEL A:

 LOTS 1, 2, 3, 4, 17, 18, 19 AND 20, BLOCK 4, DOYLE’S ADDITION TO THE CITY OF SEATTLE, ACCORDING TO THE PLAT THEREOF, RECORDED IN VOLUME 3 OF PLATS,
PAGE(S) 122, IN KING COUNTY, WASHINGTON; 
 ALSO LOTS 1, 2, 3 AND 4, BLOCK 64, LAKE UNION SHORELANDS, IN KING COUNTY, WASHINGTON, AS SHOWN ON THE OFFICIAL
MAPS ON FILE IN THE OFFICE OF THE COMMISSIONER OF PUBLIC LANDS AT OLYMPIA, WASHINGTON; 
 TOGETHER WITH THAT PORTION OF THE VACATED SOUTH 20 FEET OF EAST
GARFIELD STREET AS VACATED UNDER ORDINANCE NUMBER 88193 OF THE CITY OF SEATTLE ADJOINING AND LYING EASTERLY OF THE EASTERLY MARGIN OF FAIRVIEW AVENUE NORTH AS ESTABLISHED BY DECREE ENTERED IN KING COUNTY SUPERIOR COURT CAUSE NUMBER 204496 AND
WESTERLY OF THE WESTERLY LINE OF SAID DOYLE’S ADDITION. 
 PARCEL B: 

ALL OF LOTS 5 AND 16, AND THE NORTH 23.5 FEET OF LOTS 6 AND 15, ALL IN BLOCK 4, DOYLE’S ADDITION TO THE CITY OF SEATTLE, ACCORDING TO THE PLAT THEREOF,
RECORDED IN VOLUME 3 OF PLATS, PAGE(S) 122, IN KING COUNTY, WASHINGTON; 
 ALSO, LOT 5 AND THE NORTH 23.5 FEET OF LOT 6, BLOCK 64, LAKE UNION SHORELANDS, IN
KING COUNTY, WASHINGTON, AS SHOWN ON THE OFFICIAL MAPS ON FILE IN THE OFFICE OF THE COMMISSIONER OF PUBLIC LANDS AT OLYMPIA, WASHINGTON. 

  
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 EXHIBIT C TO LEASE 

WORK LETTER 
 THIS
WORK LETTER dated July 21, 2011 (this “Work Letter”) is made and entered into by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company
(“Landlord”), and ADAPTIVE TCR CORPORATION, a Washington corporation (“Tenant”), and is attached to and made a part of the Lease Agreement dated July 21, 2011 (the “Lease”), by
and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

1.    General Requirements. 

(a)    Tenant’s Authorized Representative. Tenant designates Chad Robins (“Tenant’s
Representative”) as the only person authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication
(“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change Tenant’s Representative at any time upon not less
than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the performance of Landlord’s Work (as hereinafter defined). 

(b)    Landlord’s Authorized Representative. Landlord designates John Cox and Tim McBride (either such
individual acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or
other Communication from or on behalf of Landlord in connection with this Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any time upon not less
than 5 business days advance written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in the performance of Landlord’s Work. 

(c)    Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that:
(i) the general contractor and any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld, conditioned or delayed, and (ii) Perkins +
Will shall be the architect (the “TI Architect”) for the Tenant Improvements. 
 2.    Tenant
Improvements. 
 (a)    Tenant Improvements Defined. As used herein, “Tenant
Improvements” shall mean all improvements to the Project of a fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in
Section 3(a) below, Landlord shall not have any obligation whatsoever with respect to the finishing of the Premises for Tenant’s use and occupancy. 

(b)    Tenant’s Space Plans. Landlord and Tenant acknowledge and agree that the plan prepared by the TI
Architect attached hereto as Exhibit I (the “Space Plan”) has been approved by both Landlord and Tenant. Landlord and Tenant further acknowledge and agree that any changes to the Space Plan constitute a Change Request the
cost of which changes shall be paid for by Tenant. Tenant shall be solely responsible for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a result of Tenant’s requested changes. 

(c)    Working Drawings. Landlord shall cause the TI Architect to prepare and deliver to Tenant for review
and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared 

 

  
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substantially in accordance with the Space Plan. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements.
Tenant shall deliver its written comments on the TI Construction Drawings to Landlord not later than 10 business days after Tenant’s receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the
Space Plan without submitting a Change Request. Landlord and the TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments, but
Tenant’s review rights pursuant to the foregoing sentence shall not delay the design or construction schedule for the Tenant Improvements. Any disputes in connection with such comments shall be resolved in accordance with
Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the Space Plan, Tenant shall approve the TI Construction Drawings submitted by Landlord, unless Tenant submits a
Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord shall not materially modify the TI Construction Drawings except as may be reasonably required in connection with the issuance
of the TI Permit (as defined in Section 3(b) below). 
 (d)    Approval and
Completion. It is hereby acknowledged by Landlord and Tenant that the TI Construction Drawings must be completed and approved not later than August 1, 2011, in order for Landlord’s Work to be Substantially Complete by the Target
Commencement Date (as defined in the Lease). Upon any dispute regarding the design of the Tenant Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the
final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such
dispute, (ii) that all costs and expenses resulting from any such decision by Tenant shall be payable by Tenant, and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building
systems. Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 

3.    Performance of Landlord’s Work. 

(a)    Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall mean
the work of constructing the Tenant Improvements. 
 (b)    Commencement and Permitting. Landlord shall
commence construction of the Tenant Improvements upon obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Tenant. The cost of
obtaining the TI Permit shall be payable by Landlord. Tenant shall assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work or any portion thereof shall impose terms
or conditions upon the construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or (iii) will materially delay the construction of
Landlord’s Work, Landlord and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. 

(c)    Completion of Landlord’s Work. Landlord shall substantially complete or cause to be
substantially completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a
non-material nature that do not interfere with the use of the Premises (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s
Work, Landlord shall require the TI Architect and the general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects
(“AlA”) document G704. For purposes of this Work Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply
with any required permit (including the TI Permit); (ii) to comply with any request by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or
(iv) to make reasonable adjustments for field deviations or conditions encountered during the construction of Landlord’s Work. 

  
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 (d)    Selection of Materials. Where more than one type of
material or structure is indicated on the TI Construction Drawings approved by Landlord and Tenant, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment that Landlord is
obligated to supply under this Work Letter, Landlord shall select the manufacturer thereof in its sole and absolute subjective discretion. 

(e)    Delivery of the Premises. When Landlord’s Work is Substantially Complete,
subject to the remaining terms and provisions of this Section 3(e), Tenant shall accept the Premises. Tenant’s taking possession and acceptance of the Premises shall not constitute a waiver of: (i) any warranty
with respect to workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of Landlord’s Work with applicable Legal
Requirements, or (iii) any claim that Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations and such other changes as are permitted hereunder) (collectively, a
“Construction Defect”). Tenant shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the
responsible contractor to remedy any such Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite Landlord’s reasonable efforts, fails
to remedy such Construction Defect within such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to cooperate, at no cost to Landlord,
with Tenant should Tenant elect to pursue a claim against such contractor. 
 (f)    Tenant shall be entitled to
receive the benefit of all construction warranties and manufacturer’s equipment warranties relating to equipment installed in the Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and
suppliers of such equipment, but the cost of any such extended warranties shall be borne solely by Tenant. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. 

(g)    Commencement Date Delay. Except as otherwise provided in the Lease, Delivery of the Premises shall
occur when Landlord’s Work has been Substantially Completed, except to the extent that completion of Landlord’s Work shall have been actually delayed by any one or more of the following causes (“Tenant Delay”): 

(i)    Tenant’s Representative was not available within 1 business day to give or receive any
Communication or to take any other action required to be taken by Tenant hereunder; 

(ii)    Tenant’s request for Change Requests (as defined in Section 4(a)
below) whether or not any such Change Requests are actually performed; 
 (iii)    Construction of any
Change Requests; 
 (iv)    Tenant’s request for materials, finishes or installations requiring
unusually long lead times, Tenant’s request for materials, finishes or installations requiring unusually long lead times, provided that promptly after Landlord learns of such long lead times, Landlord informs Tenant that the requested items
will require unusually long lead times; 
 (v)    Tenant’s delay in reviewing, revising or approving
plans and specifications beyond the periods set forth herein; 
 (vi)    Tenant’s delay in providing
information critical to the normal progression of the Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from Landlord; 

  
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 (vii)    Tenant’s delay in making payments to
Landlord for Excess TI Costs (as defined in Section 5(b) below); or 

(viii)    Any other act or omission by Tenant or any Tenant Party (as defined in the Lease), or persons
employed by any of such persons. 
 If Delivery is delayed for any of the foregoing reasons, then Landlord shall cause the TI Architect to certify the date
on which the Tenant Improvements would have been completed but for such Tenant Delay and such certified date shall be the date of Delivery. 

4.    Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by
Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be subject to the written approval of Landlord and the TI Architect, such approval not to be unreasonably
withheld, conditioned or delayed. 
 (a)    Tenant’s Request For Changes. If Tenant shall
request changes to the Tenant Improvements (“Changes”), Tenant shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”),
which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, use commercially reasonable efforts to respond to
Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant
to the extent actually incurred, whether or not such change is implemented). Landlord shall thereafter submit to Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required
depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including, without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which
Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work caused by a Change, including any suspension of Landlord’s Work while any such Change is being evaluated and/or designed, shall be
Tenant Delay. 
 (b)    Implementation of Changes. If Tenant: (i) approves in writing the cost
or savings and the estimated extension in the time for completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required in connection with such Change, Landlord shall cause the approved Change to be
instituted. Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the TI Architect’s determination of the amount of Tenant Delay in connection with such Change shall be final and
binding on Landlord and Tenant. 
 5.    Costs. 

(a)    TI Costs. Landlord shall be responsible for the payment of design, permits and construction costs in
connection with the construction of the Tenant Improvements, including, without limitation, the cost of preparing the TI Construction Drawings and the Space Plans, Landlord’s
out-of-pocket expenses and a cabling allowance of $3.00 per rentable square foot of the Premises (collectively, “TI Costs”). Notwithstanding anything to the
contrary contained herein, except for the cabling allowance of $3.00 per rentable square foot of the Premises, Landlord shall not be required to pay for purchase any furniture, personal property or other
non-Building system materials or equipment, including, but not limited to, Tenant’s voice or data cabling, non-ducted biological safety cabinets and other
scientific equipment not incorporated into the Tenant Improvements. 
 (b)    Excess TI Costs.
Notwithstanding anything to the contrary contained herein, Tenant acknowledges and agrees that Landlord shall have no responsibility for any costs arising from or related to Tenant’s changes to the Space Plan or TI Construction Drawings, Tenant
Delays, the cost of Changes and Change Requests (collectively, “Excess TI Costs”). Tenant shall deposit with Landlord, as a condition precedent to Landlord’s obligation to complete the Tenant Improvements, 100% of the Excess

  
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TI Costs. If Tenant fails to deposit any Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not
limited to, the right to interest at the Default Rate and the right to assess a late charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. 

6.    Tenant Access. 

(a)    Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s
sole risk and expense, to the Building (i) 30 days prior to the Commencement Date to perform any work (“Tenant’s Work”) required by Tenant other than Landlord’s Work, provided that such Tenant’s Work is coordinated
with the TI Architect and the general contractor, and complies with the Lease and all other reasonable restrictions and conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe work in
process; all such access shall be during normal business hours or at such other times as are reasonably designated by Landlord. Notwithstanding the foregoing, Tenant shall have no right to enter onto the Premises or the Project unless and until
Tenant shall deliver to Landlord evidence reasonably satisfactory to Landlord demonstrating that any insurance reasonably required by Landlord in connection with such pre-commencement access (including, but
not limited to, any insurance that Landlord may require pursuant to the Lease) is in full force and effect. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord until completion of
Landlord’s Work and acceptance thereof by Tenant. 
 (b)    No Interference. Neither Tenant
nor any Tenant Party (as defined in the Lease) shall interfere with the performance of Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord
shall have the right to exclude Tenant and any Tenant Party from the Premises and the Project until Substantial Completion of Landlord’s Work or such earlier time that Tenant or Tenant Party’s presence at the Premises will not interfere
with Landlord’s Work. 
 (c)    No Acceptance of Premises. The fact that Tenant may, with
Landlord’s consent, enter into the Project prior to the date Landlord’s Work is Substantially Complete for the purpose of performing Tenant’s Work shall not be deemed an acceptance by Tenant of possession of the Premises, but in such
event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and against any loss of or damage to Tenant’s property, completed work, fixtures, equipment, materials or merchandise, and from
liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party. 

7.    Miscellaneous. 

(a)    Consents. Whenever consent or approval of either party is required under this Work Letter, that
party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to the contrary. 

(b)    Modification. No modification, waiver or amendment of this Work Letter or of any of its
conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

  
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 EXHIBIT D TO LEASE 

ACKNOWLEDGMENT OF COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF COMMENCEMENT DATE is made this
                 day of                 ,
                , between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”),
and ADAPTIVE TCR CORPORATION, a Washington corporation (“Tenant”), and is attached to and made a part of the Lease dated
                , 2011 (the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have
the meanings given them in the Lease. 
 Landlord and Tenant hereby acknowledge and agree, for all purposes of the Lease, that the
Commencement Date of the Base Term of the Lease is                 ,
                , the Rent Commencement Date is                 ,
                , and the termination date of the Base Term of the Lease shall be midnight on
                ,                 , In case of a conflict between the terms
of the Lease and the terms of this Acknowledgment of Commencement Date, this Acknowledgment of Commencement Date shall control for all purposes. 

IN WITNESS WHEREOF, Landlord and Tenant have executed this ACKNOWLEDGMENT OF COMMENCEMENT DATE to be effective on the date first above
written. 
  

							
	TENANT:
	
	ADAPTIVE TCR CORPORATION,
	a Washington corporation
		
	By:	 	
                    

	Its:	 	
                    

	
	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
	a Delaware limited liability company
		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
				
		 		 	By:	 	
                    

		 		 	Its:	 	  

  
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	Rules and Regulations	 	1551 Eastlake/Adaptive TCR Corporation - Page 1

  

 EXHIBIT E TO LEASE 

Rules and Regulations 

1.    The sidewalk, entries, and driveways of the Project shall not be obstructed by Tenant, or any Tenant Party, or used
by them for any purpose other than ingress and egress to and from the Premises. 
 2.    Tenant shall not place any
objects, including antennas, outdoor furniture, etc., in the parking areas, landscaped areas or other areas outside of its Premises, or on the roof of the Project. 

3.    Except for animals assisting the disabled, no animals shall be allowed in the offices, halls, or corridors in the
Project. 
 4.    Tenant shall not disturb the occupants of the Project or adjoining buildings by the use of any radio
or musical instrument or by the making of loud or improper noises. 
 5.    If Tenant desires telegraphic, telephonic or
other electric connections in the Premises, Landlord or its agent will direct the electrician as to where and how the wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted. Any such installation or
connection shall be made at Tenant’s expense. 
 6.    Tenant shall not install or operate any steam or gas engine
or boiler, or other mechanical apparatus in the Premises, except as specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is expressly prohibited. Explosives or other articles
deemed extra hazardous shall not be brought into the Project. 
 7.    Parking any type of recreational vehicles is
specifically prohibited on or about the Project. Except for the overnight parking of operative vehicles, no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it shall be removed within 48
hours. There shall be no “For Sale” or other advertising signs on or about any parked vehicle. All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All parking will be open parking,
and no reserved parking, numbering or lettering of individual spaces will be permitted except as specified by Landlord. 

8.    Tenant shall maintain the Premises free from rodents, insects and other pests. 

9.    Landlord reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is
intoxicated or under the influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the Project. 

10.    Tenant shall not cause any unnecessary labor by reason of Tenant’s carelessness or indifference in the
preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring, or for any damage done to the effects of Tenant by the janitors or any other employee or person.

 11.    Tenant shall give Landlord prompt notice of any defects in the water, lawn sprinkler, sewage, gas pipes,
electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 

12.    Tenant shall not permit storage outside the Premises, including without limitation, outside storage of trucks and
other vehicles, or dumping of waste or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises. 

  
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	Rules and Regulations	 	1551 Eastlake/Adaptive TCR Corporation - Page 2

  

 13.    All moveable trash receptacles provided by the trash disposal firm
for the Premises must be kept in the trash enclosure areas, if any, provided for that purpose. 
 14.    No auction,
public or private, will be permitted on the Premises or the Project. 
 15.    No awnings shall be placed over the
windows in the Premises except with the prior written consent of Landlord. 
 16.    The Premises shall not be used for
lodging, sleeping or cooking or for any immoral or illegal purposes or for any purpose other than that specified in the Lease. No gaming devices shall be operated in the Premises. 

17.    Tenant shall ascertain from Landlord the maximum amount of electrical current which can safely be used in the
Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use more than such safe capacity. Landlord’s consent to the installation of electric equipment
shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 
 18.    Tenant
assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 
 19.    Tenant shall not
install or operate on the Premises any machinery or mechanical devices of a nature not directly related to Tenant’s ordinary use of the Premises and shall keep all such machinery free of vibration, noise and air waves which may be transmitted
beyond the Premises. 

  
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 EXHIBIT F TO LEASE 

TENANT’S PERSONAL PROPERTY 

None. 

  
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 EXHIBIT G TO LEASE 

ASBESTOS DISCLOSURE 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 1551 Eastlake Avenue, Seattle, WA (“Building”) and in
accordance with Washington Administrative Code, Chapter 296-62-07721. 

Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building products
were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. 

An asbestos survey of the Building has determined that ACMs and/or materials that might contain ACMs, referred to as presumed asbestos-containing materials or
PACMs, are present within or about the Premises as follows: 
  

			
	Material Description	  	Material Location
	Floor Mastic (not covered by floor tile)	  	Various locations within the parking garage
	Flooring Material and Mastic beneath new floor tile (PACM)	  	Landings of stairwells #1 and #2

 Because ACMs and PACMs are present and may continue to be present within or about the Building, we have hired an independent
environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the
Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such AGMs or PACMs. Appropriate
personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M Program describes the risks associated with
asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically
occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the
lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. 

The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be
aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. 

The O&M Program is available for review during regular business hours at our office located at 1600 Fairview Avenue East, Suite 100, Seattle WA 98102.

  
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 FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of August 26, 2011, by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE TCR CORPORATION, a Washington corporation (“Tenant”). 

RECITALS 

A.    Landlord and Tenant are now parties to that certain Lease dated as of July 21, 2011 (the
“Lease”). Pursuant to the Lease, Tenant leases certain premises (“Premises”) consisting of approximately 7,724 rentable square feet in a building located at 1551 Eastlake Avenue, Seattle, Washington
(“Building”). The Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B.    Landlord and Tenant desire to amend the Lease subject to the terms and conditions set forth below. 

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and
conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	 Sales Tax Deferral/Exemption. 

(a)    Landlord has advised Tenant that Retail sales tax otherwise applicable to portions of construction of the Tenant
Improvements may be eligible for deferral pursuant to RCW 82.63 (the “Sales Tax Deferral”) as a result of Tenant’s intended use of the Premises. Tenant has advised Landlord that Tenant intends to conduct biotechnology research
and development in the Premises. Landlord believes that approximately 60% of Tenant’s Premises will qualify for a Sales Tax Deferral, for the cost of construction of the Tenant Improvements. The Base Rent under this Lease reflects Tenant’s
receipt of the benefit of this Sales Tax Deferral in the form of a lower Base Rent. Promptly following the execution of this Lease, Landlord shall prepare and process applications with the Washington State Department of Revenue for a deferral of
state and local sales and use taxes with respect to the construction of the Tenant Improvements. Tenant shall, at Landlord’s sole cost and expense, cooperate with Landlord’s preparation and processing of such applications. Landlord shall
notify Tenant in writing once the Sales Tax Deferral has been granted by the Department of Revenue. If the retail sales tax for any of the Tenant Improvements requested by Landlord is deferred, and if, for any reason, other than Tenant’s
failure to complete the annual survey required by RCW 82.63.020, any part of the retail sales tax so deferred is subsequently required to be repaid, Landlord shall promptly pay the same, together with any interest, penalties, or other charges that
are or become due in connection therewith, and Landlord shall indemnify and hold Tenant harmless from any and all costs, expenses, losses, damages, liability and claims arising out of or related to any retail sales tax deferral for the Tenant
Improvements. If any part of the Sales Tax Deferral is required to be repaid because Tenant failed to complete the annual survey required by RCW 82.63.020, Tenant shall promptly pay the same, together with any interest, penalties or other charges
that are or become due in connection therewith, and Tenant shall indemnify and hold Landlord harmless from any and all costs, expenses, loss, damages, liability and claims arising out of or related to such loss of the Sales Tax Deferral. 

(b)    Tenant shall on an annual basis report to Landlord the nature of Tenant’s use of the Premises and the extent
to which such use does not qualify for the Sales Tax Deferral and complete the annual survey required by RCW 82.63.020. Tenant shall, after consultation with Landlord, be responsible for reporting any
non-qualifying use to the State of Washington Department of Revenue and shall deliver copies of the same to Landlord concurrently with its 

  
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delivery of the same to the State of Washington Department of Revenue. Landlord acknowledges and agrees that, as between Landlord and Tenant, Landlord shall be solely responsible for paying for
any tax resulting from any non-qualifying use. 
 (c)    Tenant will, at
Landlord’s sole cost and expense, reasonably cooperate with and assist Landlord in any challenges or audits to the Sales Tax Deferral benefit. In any contest regarding the Sales Tax Deferral benefit, Landlord shall be the main contact with the
Department of Revenue; provided, however, that Landlord shall promptly provide Tenant with copies of any correspondence between Landlord and the Department of Revenue and Tenant shall have the right to be present at any and all meetings or
proceedings relating to any such contest. Landlord and Tenant shall promptly notify each other of any such challenges or audits that they become aware of and will promptly forward to one another any correspondence regarding any such challenge or
audit. Landlord shall have the right to contest or review any proceedings regarding the Sales Tax Deferral benefit, which may be instituted either during or after the Term of this Lease. Tenant will on a timely basis execute all reasonably necessary
instruments submitted by Landlord to Tenant for execution in connection with any such protest, appeal or other proceedings, provided, however, that the same are reasonably acceptable to Tenant. If any proceeding may only be instituted and maintained
by Tenant, then Tenant shall do so at Landlord’s cost and expense upon the request of Landlord. Tenant shall not settle any appeal or other proceeding with respect to such Sales Tax Deferral without obtaining Landlord’s prior written
approval in each instance (not to be unreasonably withheld, conditioned or delayed). Landlord shall be entitled to any resulting refund obtained by reason of any such proceeding or otherwise, whether obtained during or after the expiration of the
Term and whether obtained by Landlord or Tenant. Landlord shall indemnify and hold Tenant harmless from any and all costs, expenses, losses, damages, liability and claims arising out of or related to Tenant’s compliance with the provisions of
this Section 1(c), including, without limitation, as a result of the execution of any instruments provided to Tenant by Landlord for execution. 
  

	2.	 Miscellaneous. 

a.    This First Amendment is the entire agreement between the parties with respect to the subject matter hereof and
supersedes all prior and contemporaneous oral and written agreements and discussions. This First Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b.    This First Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective agents,
employees, representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 

c.    This First Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but
all of which when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to
any other counterpart identical thereto except having additional signature pages executed by other parties to this First Amendment attached thereto. 

d.    Except as amended and/or modified by this First Amendment, the Lease is hereby ratified and confirmed and all other
terms of the Lease shall remain in full force and effect, unaltered and unchanged by this First Amendment. In the event of any conflict between the provisions of this First Amendment and the provisions of the Lease, the provisions of this First
Amendment shall prevail. Whether or not specifically amended by this First Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this First Amendment. 

[Signatures are on the next page.] 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this First Amendment as of the
day and year first above written. 
  

					
	TENANT:
	
	ADAPTIVE TCR CORPORATION,
	a Washington corporation
			
	By:	 		 	 /s/ Chad Robins

	Its:	 		 	 President & CEO

	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
	a Delaware limited liability company
		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P., a

Delaware limited partnership,
 managing member

		
	By:	 	 ARE-QRS CORP.,
 a Maryland
corporation,
 general partner

			
		 	 By:
  
	 	  
 /s/ Jennifer Pappas

		 	Its:	 	 SVP - GENERAL COUNSEL

  
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 AMENDED AND RESTATED SECOND AMENDMENT TO LEASE 

THIS AMENDED AND RESTATED SECOND AMENDMENT TO LEASE AMENDS, RESTATES AND SUPERSEDES IN ITS ENTIRETY THAT CERTAIN SECOND AMENDMENT TO LEASE
DATED AS OF MARCH 31, 2014, BY AND BETWEEN TENANT (AS DEFINED BELOW) AND LANDLORD (AS DEFINED BELOW). 
 THIS AMENDED AND RESTATED
SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of June 30, 2014, by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company
(“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation (“Tenant”). 

RECITALS 

A.    Landlord and Tenant are now parties to that certain Lease Agreement dated as of July 21, 2011
(“Original Lease”), as amended by that certain First Amendment to Lease dated as of August 26, 2011 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises (“Original
Premises”) located on the second floor, as shown on Exhibit A to the Original Lease, of that certain building located at 1551 Eastlake Avenue, Seattle, Washington. The Original Premises are more particularly described in the Lease.
Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B.    Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to, among
other things, (i) expand the size of the Original Premises by adding that certain portion of the second floor of the Building shown on Exhibit A attached to this Second Amendment (“Expansion Premises”), and
(ii) extend the Base Term of the Lease. 
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated
herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	 Expansion Premises. In addition to the Original Premises, commencing on the Expansion Premises
Commencement Date (as defined below), Landlord leases to Tenant, and Tenant leases from Landlord, the Expansion Premises. 

  

	2.	 Delivery. Landlord shall use reasonable efforts to deliver possession of the Expansion Premises
to Tenant with Landlord’s Work Substantially Completed (“Delivery” or “Deliver”) on or before the Target Expansion Premises Commencement Date. The “Target Expansion Premises Commencement Date”
shall be December 1, 2014. If Landlord fails to timely Deliver the Expansion Premises, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Lease with respect to the Expansion Premises shall not be void or
voidable, except as otherwise provided in this paragraph. If Landlord does not Deliver the Expansion Premises within 90 days of the Target Expansion Premises Commencement Date for any reason other than Force Majeure delays and Tenant Delays, the
Lease with respect to the Expansion Premises only may be terminated by Tenant by written notice to Landlord, and if so terminated by Tenant: (a) all of the provisions of this Second Amendment shall terminate and be of no further force or
effect, and (b) neither Landlord nor Tenant shall have any further rights, duties or obligations under the Lease with respect to the Expansion Premises, except with respect to provisions which expressly survive termination of the Lease. As used
herein, the terms “Landlord’s Work,” “Tenant Delays” and “Substantially Completed” shall have the meanings set forth for such terms in the Expansion Premises Work Letter attached to this Second
Amendment as Exhibit B. 

  

			
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 The “Expansion Premises Commencement Date” shall be the earlier of:
(i) the date Landlord Delivers the Expansion Premises to Tenant; or (ii) the date Landlord could have Delivered the Expansion Premises but for Tenant Delays. The “Expansion Premises Rent Commencement Date” shall be the
date that is 4 months after the Expansion Premises Commencement Date. Upon the request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Expansion Premises Commencement Date, the Expansion Premises Rent Commencement Date
and the expiration date of the Lease in substantially the form of the “Acknowledgement of Commencement Date” attached to the Lease as Exhibit D; provided, however, Tenant’s failure to execute and deliver such
acknowledgment shall not affect Landlord’s rights hereunder. 
 Except as set forth in the Expansion Premises Work Letter:
(i) Tenant shall accept the Expansion Premises in their condition as of the Expansion Premises Commencement Date, subject to all applicable Legal Requirements; (ii) Landlord shall have no obligation for any defects in the Expansion
Premises; and (iii) Tenant’s taking possession of the Expansion Premises shall be conclusive evidence that Tenant accepts the Expansion Premises and that the Expansion Premises were in good condition at the time possession was taken. 

Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the
condition of all or any portion of the Expansion Premises, and/or the suitability of the Expansion Premises for the conduct of Tenant’s business, and Tenant waives any implied warranty that the Expansion Premises are suitable for the Permitted
Use. 
  

	3.	 Premises and Rentable Area of Premises. Commencing on the Expansion Premises Commencement Date,
the defined terms “Premises” and “Rentable Area of Premises” on page 1 of the Lease shall be deleted in their entirety and replaced with the following: 

“Premises: That portion of the second floor of the Project containing approximately 20,324 rentable square feet, consisting of the
“Original Premises” and the “Expansion Premises”, all as shown on Exhibit A.” 

“Rentable Area of Premises: 20,324 sq. ft.” 

As of the Expansion Premises Commencement Date, Exhibit A to the Lease shall be amended to include the Expansion Premises as shown on
Exhibit A attached to this Second Amendment. 
 The rentable square footage of the Premises (the Original Premises and the Expansion
Premises) has been determined in accordance with the BOMA 2010 Standard Methods of Measurement for multi-tenant buildings. 
  

	4.	 Base Term. Commencing on the Expansion Premises Commencement Date, the defined term “Base
Term” on page 1 of the Lease is deleted in its entirety and replaced with the following: 

 “Base
Term: Commencing (i) with respect to the Original Premises on the Commencement Date, and (ii) with respect to the Expansion Premises on the Expansion Premises Commencement Date and ending with respect to the entire Premises on the
date that is 64 months from the first day of the first full month after the Expansion Premises Commencement Date.” 
  

	5.	 Base Rent. 

a.    Original Premises. Tenant shall continue to pay Base Rent for the Original Premises as provided for in
the Lease through September 30, 2017. Thereafter, Base Rent payable for the Original Premises shall continue to increase on each Adjustment Date (as defined in Section 4 of the Lease) pursuant to the terms of
Section 4 of the Lease. 

  

					
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 b.    Expansion Premises. Commencing on the Expansion
Premises Rent Commencement Date (i.e., the date that is 4 months after the Expansion Premises Commencement Date), Tenant shall pay Base Rent for the Expansion Premises at the rate of $46.00 per rentable square foot of the Expansion Premises per
year. Base Rent payable for the Expansion Premises shall be increased (i) on the earlier of (x) the first Adjustment Date to occur following the Expansion Premises Commencement Date, or (y) the first anniversary of the Expansion
Premises Commencement Date (either, the “First Expansion Premises Adjustment Date”), and thereafter (ii) on each annual anniversary of the First Expansion Premises Adjustment Date (each, an “Expansion Premises
Adjustment Date”), by multiplying the Base Rent payable with respect to the Expansion Premises immediately before the First Expansion Premises Adjustment Date or Expansion Premises Adjustment Date, as applicable, by 2.5% and adding the
resulting amount to the Base Rent payable with respect to the Expansion Premises immediately before the First Expansion Premises Adjustment Date or Expansion Premises Adjustment Date, as applicable. 

Notwithstanding anything to the contrary contained herein, with respect to the Expansion Premises only, for the period commencing on the
Expansion Premises Rent Commencement Date through the last day.of the 6th month after the Expansion Premises Commencement Date, Tenant shall be required to pay Base Rent with respect to only
4,027.5 rentable square feet of the Expansion Premises. Commencing on the first day of the 7th month after the Expansion Premises Commencement Date, Tenant shall commence paying Base Rent with
respect to the entire Expansion Premises. 
  

	6.	 Tenant’s Share. Commencing on the Expansion Premises Commencement Date, the defined term
“Tenant’s Share of Operating Expenses” on page 1 of the Lease shall be deleted in its entirety and replaced with the following’ 

“Tenant’s Share of Operating Expenses: 17.30%” 
  

	7.	 Parking. Subject to all matters of record, Force Majeure, a Taking and the exercise by Landlord
of its rights hereunder, Landlord shall make available to Tenant and Tenant shall be entitled to use, at no additional cost, an addition 15 parking spaces (“Expansion Premises Parking Spaces”), which Expansion Premises Parking
Spaces shall all be located in the non-reserved parking areas of the Off-Site Parking (as defined in Section 10 of the Original Lease), as may
be modified by Landlord from time to time, subject in each case to Landlord’s rules and regulations. Landlord may allocate parking spaces among Tenant and other tenants in the Project if Landlord determines that such parking facilities are
becoming crowded, Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including other tenants of the Project. 

 

	8.	 Extension Right. For the avoidance of doubt, commencing on the Expansion Premises Commencement
Date, Tenant’s Extension Right pursuant to Section 40 of the Lease shall apply with respect to the Expansion Premises, and such Extension Right may only be exercised concurrently with respect to both the Original Premises and the
Expansion Premises. 

  

	9.	 Expansion Premises. Section 39 of the Lease is hereby deleted in its entirety and is
of no further force or effect. 

  

	10.	 Right to Terminate. Section 41 of the Lease is hereby deleted in its entirety and is of no
further force or effect. 

  

  

			
	     

    
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	11.	 Asbestos. 

a.    Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing
materials (“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the location identified in Exhibit C attached to this First Amendment. 

b.    Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (a) of
this Section 11 and understands that the purpose of such notification is to make Tenant and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order
to avoid or minimize any damage to or disturbance of such ACMs and/or PACMs. 
  

	
	CMR
	Tenant’s Initials

 c.    Acknowledgement from Contractors/Employees. Tenant shall give Landlord
at least 14 days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify
or describe the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to
determine whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval. Upon Landlord’s
request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within or about the Premises in the
locations identified in Exhibit C prior to the commencement of such activities. Nothing in this Section 11 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct, authorize or permit
any such activities. 
 (i)    Removal of thermal system insulation (“TSI”) and
surfacing ACMs and PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 

(ii)    Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or 

(iii)    Repair and maintenance of operations that are likely to disturb ACMs or PACMs. 

 

	12.	 Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker,
agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Second Amendment and that no Broker brought about this transaction, other than Cushman & Wakefield Commerce and Flinn
Ferguson. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable,
with regard to this Second Amendment. Landlord shall be responsible for all commissions due to Cushman & Wakefield Commerce and Flinn Ferguson arising out of the execution of this Second Amendment in accordance with the terms of separate
written agreements between Landlord, on the one hand, and Cushman & Wakefield Commerce and Flinn Ferguson, on the other hand. 

  

	13.	 Miscellaneous. 

a.    This Second Amendment is the entire agreement between the parties with respect to the subject matter hereof and
supersedes all prior and contemporaneous oral and written agreements and discussions. This Second Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

 

  

			
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 b.    This Second Amendment is binding upon and shall inure to the
benefit of the parties hereto, and their respective successors and assigns. 
 c.    This Second Amendment may be
executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing
the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical thereto except having additional signature pages executed by other parties to this Second Amendment attached thereto. 

d.    Except as amended and/or modified by this Second Amendment, the Lease is hereby ratified and confirmed and all
other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Second Amendment. In the event of any conflict between the provisions of this Second Amendment and the provisions of the Lease, the provisions of this
Second Amendment shall prevail. Whether or not specifically amended by this Second Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Second Amendment.

 [Signatures are on the next page.] 

  

			
	     
  
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5 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the
day and year first above written. 
  

			
	TENANT:	 	
	
	ADAPTIVE BIOTECHNOLOGIES CORPORATION,
	a Washington corporation
	
	Chad Robins

 
			
		
	By:	 	 /s/ Chad Robins

	Its:	 	 CEO & President

  

							
	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
	a Delaware limited liability company
		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P., a

Delaware limited partnership,
 managing member

			
		 	By:	 	 ARE-QRS CORP.,

a Maryland corporation,
 general partner

				
		 		 	By:	 	 /s/ Jackie Clem

		 		 	Its:	 	 VP Real Estate Legal Affairs

  
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6 

 

 

 

 

 

 

 EXHIBIT B 

Expansion Premises Work Letter 

THIS EXPANSION PREMISES WORK LETTER dated June 30, 2014 (this “Expansion Premises Work Letter”) is made and entered into
by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation
(“Tenant”), and is attached to and made a part of the Lease Agreement dated July 21, 2011, as amended by that certain First Amendment to Lease dated as of August 26, 2011, and as further amended by that certain Amended and
Restated Second Amendment to Lease dated of even date herewith (as amended, the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the
Lease. 
 1.    General Requirements. 

(a)    Tenant’s Authorized Representative. Tenant designates Chad Robins (“Tenant’s
Representative”) as the only person authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication
(“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change Tenant’s Representative at any time upon not less
than 5 business days advance written notice to Landlord. 
 (b)    Landlord’s Authorized Representative.
Landlord designates John Cox (“Landlord’s Representative”) as the only person authorized to act for Landlord pursuant to this Expansion Premises Work Letter. Tenant shall not be obligated to respond to or act upon any request,
approval, inquiry or other Communication from or on behalf of Landlord in connection with this Expansion Premises Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change Landlord’s
Representative at any time upon not less than 5 business days advance written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in the performance of Landlord’s Work,

 (c)    Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that:
(i) the general contractor and any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld. conditioned or delayed, and (ii) Perkins +
Will shall be the architect (the “TI Architect”) for the Tenant Improvements. 
 2.    Tenant
Improvements. 
 (a)    Tenant Improvements Defined. As used herein, “Tenant Improvements”
shall mean all improvements to the Expansion Premises of a fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in
Section 3(a) below, Landlord shall not have any obligation whatsoever with respect to the finishing of the Expansion Premises for Tenant’s use and occupancy. 

(b)    Tenant’s Space Plans. Landlord and Tenant acknowledge and agree that the plan prepared by the TI
Architect attached to this Expansion Premises Work Letter as Schedule 1 (the “Space Plan”) has been approved by both Landlord and Tenant. Landlord and Tenant further acknowledge and agree that any changes to the Space Plan
constitute a Change Request the cost of which changes shall be paid for by Tenant. Tenant shall be solely responsible for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a result of Tenant’s
requested changes. 
 (c)    Working Drawings. Landlord shall cause the TI Architect to prepare and deliver to
Tenant for review and comment construction plans, specifications and drawings for the Tenant 

  
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B-1 

 
Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared substantially in accordance with the Space Plan. Tenant shall be solely responsible
for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Tenant shall deliver its written comments on the TI Construction Drawings to Landlord not later than 10 business days after Tenant’s
receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the Space Plan without submitting a Change Request. Landlord and the TI Architect shall consider all such comments in good faith and shall,
within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments, but Tenant’s review rights pursuant to the foregoing sentence shall not delay the design or construction schedule for the Tenant
Improvements. Any disputes in connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the Space Plan,
Tenant shall approve the TI Construction Drawings submitted by Landlord, unless Tenant submits a Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord shall not materially modify
the TI Construction Drawings except as may be reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(b) below). Landlord shall notify Tenant of any such material modifications as may
be reasonably required in connection with the issuance of the TI Permit. 
 (d)    Approval and Completion. Upon
any dispute regarding the design of the Tenant Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant
Improvements, provided (i) Tenant acts reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all costs and expenses
resulting from any such decision by Tenant shall be payable by Tenant, except to the extent that the design chosen by Tenant is already included within the scope the Space Plan, and (iii) Tenant’s decision will not affect the base
Building, structural components of the Building or any Building Systems. Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in
Section 4 hereof. 
 3.    Performance of Landlord’s Work. 

(a)    Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall mean the
work of constructing the Tenant Improvements. 
 (b)    Commencement and Permitting. Landlord shall commence
construction of the Tenant Improvements upon obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Tenant, The cost of
obtaining the TI Permit shall be payable by Landlord. Tenant shall assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work or any portion thereof shall impose terms
or conditions upon the construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or (iii) will materially delay the construction of
Landlord’s Work, Landlord and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions 

(c)    Completion of Landlord’s Work. Landlord shall substantially complete or cause to be substantially
completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a non-material nature
that do not interfere with the use of the Expansion Premises and shall obtain a permit card issued by the applicable Governmental Authority or verbal approval from the building inspector permitting occupancy of the Expansion Premises
(“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s Work, Landlord shall require the TI Architect and the general contractor to execute and deliver, for the benefit
of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Expansion Premises Work Letter, “Minor Variations”
shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit 

  

			
	     
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(including the TI Permit); (ii) to comply with any request by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices
that are not material; or (iv) to make reasonable adjustments for field deviations or conditions encountered during the construction of Landlord’s Work. 

(d)    Selection of Materials. Where more than one type of material or structure is indicated on the TI
Construction Drawings approved by Landlord and Tenant, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment that Landlord is obligated to supply under this Expansion
Premises Work Letter, Landlord shall select the manufacturer thereof in its sole and absolute subjective discretion. 

(e)    Delivery/Acceptance. When Landlord’s Work is Substantially Complete, subject to the remaining terms and
provisions of this Section 3(e), Tenant shall accept Delivery of the Expansion Premises. Tenant’s taking possession and acceptance of the Expansion Premises shall not constitute a waiver of: (i) any warranty with
respect to workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of Landlord’s Work with applicable Legal
Requirements, or (iii) any claim that Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations and such other changes as are permitted hereunder) (collectively, a
“Construction Defect”). Tenant shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the
responsible contractor to remedy any such Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite Landlord’s reasonable efforts, fails
to remedy such Construction Defect within such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to cooperate, at no cost to Landlord,
with Tenant should Tenant elect to pursue a claim against such contractor. 
 Tenant shall be entitled to receive the benefit of all
construction warranties and manufacturer’s equipment warranties relating to equipment installed in the Expansion Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and suppliers of such
equipment, but the cost of any such extended warranties shall be borne solely by Tenant. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. Landlord shall endeavor, in connection with Landlord’s
completion of such punch list items, to minimize interference with Tenant’s use of the Expansion Premises for the Permitted Use. 

(f)    Expansion Premises Commencement Date Delay. Except as otherwise provided in the Lease, Delivery of the
Expansion Premises shall occur when Landlord’s Work has been Substantially Completed in the Expansion Premises, except to the extent that completion of Landlord’s Work shall have been actually delayed by any one or more of the following
causes (“Tenant Delay”): 
 (i)    Tenant’s Representative was not available to
give or receive any Communication or to take any other action required to be taken by Tenant hereunder; 

(ii)    Tenant’s request for Change Requests (as defined in Section 4(a)
below) whether or not any such Change Requests are actually performed; 
 (iii)    Construction of any
Change Requests; 
 (iv)    Tenant’s request for materials, finishes or installations requiring
unusually long lead times, provided that Landlord notifies Tenant of such long lead times prior to any delay in the completion of Landlord’s Work; 

(v)    Tenant’s delay in reviewing, revising or approving plans and specifications beyond the periods
set forth herein; 

  

			
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B-3 

 (vi)    Tenant’s delay in providing information
critical to the normal progression of the Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from Landlord; 

(vii)    Tenant’s delay in making payments to Landlord for Excess TI Costs (as defined in
Section 5(b) below); or 
 (viii)    Any other act or omission by Tenant or any
Tenant Party (as defined in the Lease), or persons employed by any of such persons. 
 If Delivery is delayed for any of the foregoing reasons, then
Landlord shall cause the TI Architect to certify the date on which the Tenant Improvements would have been Substantially Completed in the Expansion Premises but for such Tenant Delay and such certified date shall be the date of Delivery. 

4.    Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by
Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be subject to the written approval of Landlord and the TI Architect, such approval not to be
unreasonably withheld, conditioned or delayed. 
 (a)    Tenant’s Request For Changes. If Tenant shall
request changes to the Tenant Improvements (“Changes”), Tenant shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”),
which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, use commercially reasonable efforts to respond to
Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant
to the extent actually incurred, whether or not such change is implemented). Landlord shall thereafter submit to Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required
depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including, without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which
Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work caused by a Change, including any suspension of Landlord’s Work while any such Change is being evaluated and/or designed, shall be
Tenant Delay. 
 (b)    Implementation of Changes. If Tenant: (i) approves in writing the cost or savings
and the estimated extension in the time for completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required in connection with such Change, Landlord shall cause the approved Change to be instituted.
Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the TI Architect’s determination of the amount of Tenant Delay in connection with such Change shall be final and binding on
Landlord and Tenant. 
 5.    Costs. 

(a)    TI Costs. Landlord shall be responsible for the payment of design, permits and construction costs in
connection with the construction of the Tenant Improvements, including, without limitation, the cost of preparing the TI Construction Drawings and the Space Plan and Landlord’s
out-of-pocket expenses (collectively, “TI Costs”). Notwithstanding anything to the contrary contained herein, in no event shall Landlord be required to
pay for any furniture, personal property or other non-Building system materials or equipment, including, but not limited to, Tenant’s voice or data cabling,
non-ducted biological safety cabinets and other scientific equipment not incorporated into the Tenant Improvements. 

(b)    Excess TI Costs. Notwithstanding anything to the contrary contained herein, Tenant acknowledges and agrees
that Landlord shall have no responsibility for any costs arising from or related 

  

			
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to Tenant’s changes to the Space Plan or approved TI Construction Drawings, Tenant Delays, the cost of Changes and Change Request (collectively, “Excess TI Costs”). Tenant
shall deposit with Landlord, as a condition precedent to Landlord’s obligation to complete the Tenant Improvements, 100% of the Excess TI Costs, If Tenant fails to deposit any Excess TI Costs with Landlord, Landlord shall have all of the rights
and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the Default Rate and the right to assess a late charge). For purposes of any litigation instituted with regard to such amounts, those
amounts will be deemed Rent under the Lease. 
 6.    Tenant Access. 

(a)    Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s sole risk and
expense, to the Expansion Premises (i) 30 days prior to the Expansion Premises Commencement Date provided such access is coordinated with the TI Architect and the general contractor, and complies with the Lease and all other reasonable restrictions
and conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe work in process; all such access shall be during normal business hours or at such other times as are reasonably designated by
Landlord. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord until completion of Landlord’s Work and acceptance thereof by Tenant. 

(b)    No Interference. Neither Tenant nor any Tenant Party (as defined in the Lease) shall interfere with the
performance of Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord shall have the right to exclude Tenant and any Tenant Party from the
Expansion Premises until Substantial Completion of Landlord’s Work. 
 (c)    No Acceptance of Expansion
Premises. The fact that Tenant may, with Landlord’s consent, enter into the Expansion Premises prior to the date Landlord’s Work is Substantially Complete shall not in and of itself be deemed an acceptance by Tenant of possession of
the Expansion Premises, but in such event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and against any loss of or damage to Tenant’s property, completed work, fixtures, equipment,
materials or merchandise, and from liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party. 

7.    Miscellaneous. 

(a)    Consents. Whenever consent or approval of either party is required under this Expansion Premises Work Letter,
that party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to the contrary. 

(b)    Modification. No modification, waiver or amendment of this Expansion Premises Work Letter or of any of its
conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

  

			
	     
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B-5 

 

 

 Exhibit C 

Asbestos Disclosure 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 1551 Eastlake Avenue, Seattle, WA (“Building”)
and in accordance with Washington Administrative Code, Chapter 296-62-07721. 

Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building products
were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. 

An asbestos survey of the Building has determined that ACMs and/or materials that might contain ACMs, referred to as presumed asbestos-containing materials or
PACMs, are present within or about the Premises as follows: 
  

			
	 Material Description
	  	 Material Location

	Floor Mastic (not covered by floor tile)	  	Various locations within the parking garage
		
	Flooring Material and Mastic beneath new floor tile (PACM)	  	Landings of stairwells #1 and #2

 Because ACMs and PACMs are present and may continue to be present within or about the Building, we have hired an independent
environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the
Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate
personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M Program describes the risks associated with
asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically
occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the
lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. 

The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be
aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. 

The O&M Program is available for review during regular business hours at our office located at 1600 Fairview Avenue East, Suite 100, Seattle WA 98102.

  

			
	     

    
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c-i 

 THIRD AMENDMENT TO LEASE 

THIS THIRD AMENDMENT TO LEASE (this “Third Amendment”) is made as of November 5, 2015, by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation (“Tenant”). 

RECITALS 
 A. Landlord and Tenant
are now parties to that certain Lease Agreement dated as of July 21, 2011 (“Original Lease”), as amended by that certain First Amendment to Lease dated as of August 26, 2011, and as further amended by that certain Amended
and Restated Second Amendment to Lease dated as of June 30, 2014 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises (the “Existing Premises”) located on the second floor consisting
of approximately 20,324 rentable square feet in that certain building located at 1551 Eastlake Avenue, Seattle, Washington. The Existing Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall
have the meanings defined for such terms in the Lease. 
 B. Landlord and Tenant desire, subject to the terms and conditions set forth below,
to amend the Lease to, provide for the temporary use by Tenant of that certain portion of the third floor of the Building, consisting of approximately 9,594 rentable square feet, as shown on Exhibit A attached to this Third Amendment
(“Third Floor Space”). 
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein
by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	 Temporary Expansion Premises. Commencing on the date that is 1 business day after the mutual
execution and delivery of this Third Amendment by the parties (“Third Floor Space Commencement Date”), and continuing until the date that is 6 months after the Third Floor Space Commencement Date (“Third Floor Space
Term”), Landlord shall lease to Tenant and Tenant shall lease from Landlord the Third Floor Space. Tenant acknowledges and agrees that all of the terms and conditions of the Lease shall apply to the leasing of the Third Floor Space, except
that (a) the term of the lease with respect to the Third Floor Space shall be as set forth in the first sentence of this Section 1; (b) Tenant shall not be required to pay Base Rent with respect to the Third Floor
Space during the Third Floor Space Term; (c) Tenant shall commence paying Tenant’s Share of Operating Expenses with respect to the Third Floor Space (which is equal to 8.29%) on the Third Floor Space

  

			
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Commencement Date and Tenant shall continue to pay Tenant’s Share of Operating Expenses with respect to the Third Floor Space thereafter on the first day of each month during the Third Floor
Space Term; (d) Landlord shall not be required to make any improvements to the Third Floor Space or provide any tenant improvement allowance with respect to the Third Floor Space and Tenant shall accept the Second Floor in its ‘as is”
condition; (e) Tenant shall not be required to deliver any additional Security Deposit with respect to the Third Floor Space; (f) notwithstanding anything to the contrary contained in Section 22 of the original
Lease, Tenant shall not have the right to sublease any portion of the Third Floor Space or assign the Lease with respect to the Third Floor Space; (g) Tenant may not make any Alterations or any other improvements in the Third Floor Space
without the prior written approval of Landlord, which approval may be granted or withheld in Landlord’s sole and absolute discretion; and (h) any existing Extension Rights relating to the Existing Premises shall not apply to the Third
Floor Space. 

 Tenant shall surrender the Third Floor Space upon the expiration of the Third Floor Space Term in accordance
with the surrender requirements contained in the Lease. Following the expiration or earlier termination of the Third Floor Space Term, Tenant shall have no further rights of any kind with respect to the Third Floor Space. Nothing contained herein
shall release Tenant from any obligations under the Lease with respect to the Third Floor Space which survive the expiration or earlier termination of the Lease. 

2. Asbestos. 
 a. Notification
of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials (“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the location
identified in Exhibit B attached to this First Amendment. 
 b. Tenant Acknowledgement. Tenant hereby acknowledges receipt of
the notification in paragraph (a) of this Section 2 and understands that the purpose of such notification is to make Tenant and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or
PACMs within or about the Building in order to avoid or minimize any damage to or disturbance of such AGMs and/or PACMs. 
 CMR 

Tenant’s Initials 

  

			
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 c. Acknowledgement from Contractors/Employees. Tenant shall give Landlord at least 14
days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify or describe
the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to determine
whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval. Upon Landlord’s request, Tenant
shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within or about the Premises in the locations identified
in Exhibit B prior to the commencement of such activities. Nothing in this Section 2 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct, authorize or permit any such activities.

  

	 	(i)	 Removal of thermal system insulation (“TSI”) and surfacing ACMs arid PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 

 

	 	(ii)	 Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or 

 

	 	(iii)	 Repair and maintenance of operations that are likely to disturb ACMs or PACMs. 

 

	3.	 OFAC. Tenant and all beneficial owners of Tenant are currently (a) in compliance with and
shall at all times during the Term of the Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating
thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List or the Sectoral
Sanctions Identifications List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or
entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

  

			
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 4. Miscellaneous. 

a. This Third Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and
contemporaneous oral and written agreements and discussions. This Third Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This Third Amendment is binding upon and shall inure to the benefit of the parties hereto, and their respective successors and assigns. 

c. This Third Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken
together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart
identical thereto except having additional signature pages executed by other parties to this Third Amendment attached thereto. 
 d. Except
as amended and/or modified by this Third Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Third Amendment. In the event of any conflict
between the provisions of this Third Amendment and the provisions of the Lease, the provisions of this Third Amendment shall prevail. Whether or not specifically amended by this Third Amendment, all of the terms and provisions of the Lease are
hereby amended to the extent necessary to give effect to the purpose and intent of this Third Amendment. 
 [Signatures are on the next
page.] 

  

			
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 IN WITNESS WHEREOF, the parties hereto have executed this Third Amendment as of the
day and year first above written. 
  

									
	TENANT:
	
	 ADAPTIVE BIOTECHNOLOGIES CORPORATION,

a Washington corporation

		
	By:	 	 /s/ Chad Robins

	Its:	 	CEO and President
	
	LANDLORD:
	
	 ARE-SEATTLE NO. 11, LLC,

a Delaware limited liability company

		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a
		 	Delaware limited partnership, managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
				
		 		 	By:	 	 /s/ Jackie Clem

		 		 	Its:	 	Senior Vice President RE Legal Affairs

  

			
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 ACKNOWLEDGMENT 

 

			
	A notary public or other officer completing this certificate verifies only the identity of the individual who signed the document to which this certificate is attached, and not the
truthfulness, accuracy, or validity of that document.	  	

 State of California 
 County of
Los Angeles) 
  

			
	On November 9, 2015 before me,	  	 Charles L. Murphy, Notary Public

		  	 (insert name and title of the officer)

 personally appeared Jackie Clem, who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s)
is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of
which the person(s) acted, executed the instrument. 
 I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing
paragraph is true and correct. 
  

							
	WITNESS my hand and official seal.	  	            	  	

	Signature	 	 /s/ Charles L. Murphy
	  		  	(Seal)

  

			
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 TENANT’S ACKNOWLEDGMENT 

 

					
	STATE OF WA	  		  	
		  	ss.	  	
	COUNTY OF KING            	  		  	

 On this 5 day of NOVEMBER, 2015, before me personally appeared Chad Robins, to me known to be the CEO of Adaptive
Biotechnologies, a                     , that executed the within and foregoing instrument, and Acknowledged the said instrument to be the free and
voluntary act and deed of said corporation for the uses and purposes therein mentioned, and on oath stated that they were authorized to execute said instrument. 

IN WITNESS WHEREOF, I have hereunto set my hand and affixed my official seal the day and year first above written. 

 

					
		 	    	 	 /s/ Lorna Chang

(Signature of Notary)

			
	

	 		 	 Lorna Chang

	 		 	(Legiby Print or Stamp Name of Notary)
	 		 	 Notary public in and for the State of Washington, residing at Seattle, WA

My appointment expires 5.11.19

	 		 	

  

			
		  	 

 EXHIBIT A 

Third Floor Space 
  

 

 EXHIBIT B 

Asbestos Disclosure 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 1551 Eastlake Avenue, Seattle, WA (“Building”) and in
accordance with Washington Administrative Code, Chapter 296-62-07721. 

Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building products
were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or AGMs, are still sometimes found in buildings today. 

An asbestos survey of the Building has determined that ACMs and/or materials that might contain ACMs, referred to as presumed asbestos-containing materials or
PACMs, are present within or about the Premises as follows: 
  

			
	Material Description	  	Material Location
		
	Floor Mastic (not covered by floor tile)	  	Various locations within the parking garage
		
	Flooring Material and Mastic beneath new floor tile (PACM)	  	Landings of stairwells #1 and #2

 Because ACMs and PACMs are present and may continue to be present within or about the Building, we have hired an independent
environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the
Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate
personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M Program describes the risks associated with
asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically
occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the
lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. 

  

			
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Copy or Distribute. Alexandria and the Alexandria Logo are

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 The O&M Program describes a number of activities that should be avoided in order to prevent a release of
asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person
not qualified to handle ACMs. 
 The O&M Program is available for review during regular business hours at our office located at 1600 Fairview Avenue
East, Suite 100, Seattle WA 98102. 

  

			
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 FOURTH AMENDMENT TO LEASE 

THIS FORTH AMENDMENT TO LEASE (this “Forth Amendment”) is made as of December 23, 2015, by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation (“Tenant”). 

RECITALS 
 A.
Landlord and Tenant are now parties to that certain Lease Agreement dated as of July 21, 2011, as amended by that certain First Amendment to Lease dated as of August 26, 2011, as further amended by that certain Amended and Restated Second
Amendment to Lease dated as of June 30, 2014 (the “Second Amendment”), and as further amended by that certain Third Amendment to Lease dated as of November 5, 2015 (as amended, the “Lease”). Pursuant to
the Lease, Tenant leases certain premises consisting of approximately 20,324 rentable square feet (“Existing Premises”) on the second floor of that certain building located at 1551 Eastlake Avenue, Seattle, Washington. The Existing
Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to, among other things,
(i) expand the size of the Existing Premises by adding those portions of the second and third floors of the Building consisting of approximately 28,100 rentable square feet, as shown on Exhibit A attached to this Fourth Amendment
(“Second Expansion Premises”), (ii) extend the Base Term of the Lease, and (iii) provide Tenant with an option to expand the Premises to include approximately 8,594 rentable square feet on the third floor of the Building, as
shown on Exhibit D attached hereto (the “Third Floor Option Space”). 
 NOW, THEREFORE, in consideration of
the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and
Tenant hereby agree as follows: 
  

	1.	 Second Expansion Premises. In addition to the Existing Premises, commencing on the Second
Expansion Premises Commencement Date (as defined below), Landlord leases to Tenant, and Tenant leases from Landlord, the Second Expansion Premises. 

  

	2.	 Delivery. Landlord shall use reasonable efforts to deliver possession of the Second Expansion
Premises to Tenant (“Delivery” or “Deliver”) for the performance by Tenant of Tenant Improvements in the Second Expansion Premises on or before the Target Second Expansion Premises Commencement Date. The
“Target Second Expansion Premises Commencement Date” shall be December 1, 2015. If Landlord fails to timely Deliver the Second Expansion Premises, Landlord shall not be liable to Tenant for any loss or damage resulting
therefrom, and the Lease with respect to the Second Expansion Premises shall not be void or voidable. As used herein, the term “Tenant Improvements” shall have the meaning set forth for such term in the Fourth Amendment Work Letter
attached to this Fourth Amendment as Exhibit B. 

 The “Second Expansion Premises Commencement
Date” shall be the date Landlord Delivers the Second Expansion Premises to Tenant in broom clean condition. The “Second Expansion Premises Rent Commencement Date” shall be June 1, 2016. Upon the request
of Landlord, Tenant shall execute and deliver a written acknowledgment of the Second Expansion Premises Commencement Date, the Second Expansion Premises Rent Commencement Date and the expiration date of the Lease in substantially the form of the
“Acknowledgement of Commencement Date” attached to the Lease as Exhibit D; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect either party’s rights hereunder. 

  
 1 

 The portion of the Second Expansion Premises located on the third floor, as shown on
Exhibit A attached to this Fourth Amendment, may be used as a gym for the exclusive use of Tenant’s employees (the “Gym Area”). If elected by Tenant by written notice to Landlord delivered within 12 months after the date
of this Fourth Amendment, Landlord shall perform the work and provide the gym equipment, at Landlord’s expense, described on Exhibit E attached hereto in the Gym Area (collectively, the “Gym Work”). Tenant
acknowledges that Landlord shall require access to the Gym Area following the Second Expansion Premises Commencement Date in order to complete the Gym Work. Landlord and its contractors and agents shall have the right to enter the Gym Area following
the Second Expansion Premises Commencement Date in order to perform the Gym Work. Tenant acknowledges that Landlord’s completion of the Gym Work may adversely affect Tenant’s use and occupancy of the Premises. Tenant waives all claims
against Landlord for rent abatement in connection with the Gym Work. 
 Except as set forth in the Fourth Amendment Work Letter:
(i) Tenant shall accept the Second Expansion Premises in their condition as of the Second Expansion Premises Commencement Date, subject to all applicable Legal Requirements; (ii) Landlord shall have no obligation for any defects in the
Second Expansion Premises; and (iii) Tenant’s taking possession of the Second Expansion Premises shall be conclusive evidence that Tenant accepts the Second Expansion Premises and that the Second Expansion Premises were in good condition
at the time possession was taken. 
 Tenant agrees and acknowledges that, except as otherwise expressly set forth in this Fourth Amendment or
in the Lease, neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of all or any portion of the Second Expansion Premises, and/or the suitability of the Second Expansion Premises for the
conduct of Tenant’s business, and Tenant waives any implied warranty that the Second Expansion Premises are suitable for the Permitted Use. 
  

	3.	 Premises and Rentable Area of Premises. Commencing on the Second Expansion Premises
Commencement Date, the defined terms “Premises,” “Rentable Area of Premises” and “Rentable Area of Project” on page 1 of the Lease shall be deleted in their entirety and
replaced with the following: 

 “Premises: That portion of the Building containing approximately 48,424
rentable square feet, consisting of (i) that certain portion of the second floor containing approximately 7,724 rentable square feet (the “Original Premises”), (ii) that certain portion of the second floor containing
approximately 12,600 rentable square feet (the “Expansion Premises”), and (iii) those certain portions of the second and third floors containing approximately 28,100 rentable square feet (the “Second Expansion
Premises”), all as shown on Exhibit A.” 
 “Rentable Area of Premises: 48,424 sq. ft.” 

 “Rentable Area of Project: 117,482 sq. ft “ 

As of the Second Expansion Premises Commencement Date, Exhibit A to the Lease shall be amended to include the Second Expansion Premises
as shown on Exhibit A attached to this Fourth Amendment. 

  
 2 

	4.	 Base Term Commencing on the Second Expansion Premises Commencement Date, the defined term
“Base Term” on page 1 of the Lease is deleted in its entirety and replaced with the following: 

“Base Term: Commencing (i) with respect to the Original Premises on the Commencement Date, (ii) with respect to the
Expansion Premises on the Expansion Premises Commencement Date, and (iii) with respect to the Second Expansion Premises on the Second Expansion Premises Commencement Date, and ending with respect to the entire Premises on the date that is 84
months from the first day of the first full month after the Second Expansion Premises Rent Commencement Date.” 
  

	5.	 Base Rent. 

a. Original Premises. Tenant shall continue to pay Base Rent for the Original Premises as provided for in the Lease through
June 30, 2020. Thereafter, Base Rent payable for the Original Premises shall continue to increase on each Adjustment Date (as defined in Section 4 of the Lease) pursuant to the terms of
Section 4 of the Lease. 
 b. Expansion Premises. Tenant shall continue to pay Base Rent for the
Expansion Premises as provided for in the Lease through June 30, 2020. Thereafter, Base Rent payable for the Expansion Premises shall continue to increase on each Expansion Premises Adjustment Date (as defined in
Section 5(b) of the Second Amendment) pursuant to the terms of Section 5(b) of the Second Amendment. 

c. Second Expansion Premises. Commencing on the Second Expansion Premises Rent Commencement Date (i.e., June 1, 2016),
Tenant shall pay Base Rent for the Second Expansion Premises at the rate of $45.60 per rentable square foot of the Second Expansion Premises per year. Base Rent payable for the Second Expansion Premises shall be increased on each annual anniversary
of the Second Expansion Premises Commencement Date (each, a “Second Expansion Premises Adjustment Date”), by multiplying the Base Rent payable for the Second Expansion Premises immediately before the Second Expansion Premises
Adjustment Date by 2.5% and adding the resulting amount to the Base Rent payable for the Second Expansion Premises immediately before the Second Expansion Premises Adjustment Date. 

d. Additional TI Allowance. In addition to the Tenant Improvement Allowance (as defined in the Fourth Amendment Work Letter),
Landlord shall, subject to the terms of the Fourth Amendment Work Letter, make available to Tenant the Additional Tenant Improvement Allowance (as defined in the Fourth Amendment Work Letter). To the extent that Tenant elects to use all or any
portion of the Additional Tenant Improvement Allowance and such amount elected by Tenant is actually funded by Landlord, then commencing on the Second Expansion Premises Rent Commencement Date and continuing thereafter on the first day of each month
during the Base Term, Base Rent shall be increased by $0.19 per year for each $1.00 of the Additional Tenant Improvement Allowance actually funded by Landlord, as adjusted as additional disbursements of the Additional Tenant Improvement Allowance
occur. For example, if $100,000 of the Additional Tenant Improvement Allowance is funded, Base Rent shall be increased by $19,000 per year ($100,000 x $0.19). 
  

	6.	 Tenant’s Share. Commencing on the Second Expansion Premises Commencement Date, the
defined term “Tenant’s Share of Operating Expenses” on page 1 of the Lease shall be deleted in its entirety and replaced with the following: 

“Tenant’s Share of Operating Expenses: 41.22%” 
  

	7.	 Parking. Subject to all matters of record, Force Majeure, a Taking and the exercise by
Landlord of its rights hereunder, Landlord shall make available to Tenant and Tenant shall, in addition to the parking spaces that Tenant has the right to use pursuant to Section 10 of the original Lease and the Expansion
Premises Parking Spaces which Tenant has the right to use pursuant to Section 2 of the Second Amendment, be entitled to use, at no additional cost during the Base Term, subject to the terms of
Section 10 of the original Lease, Tenant’s pro rata share of parking 

  
 3 

 spaces with respect to the Second Expansion Premises. As of the Second Expansion Premises
Commencement Date, Tenant’s pro rata share of parking spaces with respect to the Second Expansion Premises shall be equal to 2 parking spaces per 1,000 rentable square feet of the Second Expansion Premises (which is equal to 56 parking spaces
(in addition to the parking spaces that Tenant has the right to use pursuant to Section 10 of the original Lease))(“Second Expansion Premises Parking Spaces”). The Second Expansion Premises Parking
Spaces shall be allocated among the Underground Parking, Surface Parking, Northeast Parking and Offsite Parking as follows: 6 unreserved parking spaces in the Underground Parking, 4 unreserved stalls in the Surface Parking, 0 stalls in the Northeast
Parking and 46 unreserved stalls in the Offsite Parking. Notwithstanding anything to the contrary contained in the Lease, Landlord shall designate 8 parking spaces in the Surface Parking in an area outside the Building lobby, as reasonably
determined by Landlord, as “guest parking” for guests of tenants of the Building. In addition, Tenant shall be entitled, subject to the terms of Section 10 of the original Lease, to 4 additional parking spaces in
areas of the Surface Parking designated by Landlord (“Additional Parking Spaces”), which 4 Additional Parking Spaces shall be designated as “guest parking” for guests of Tenant and shall be subject to the payment by
Tenant of the market rate for each Additional Parking Space, as reasonably determined by Landlord from time to time, which as of the date of this Fourth Amendment shall be $150 per month for each Additional Parking Space plus applicable taxes 

 

	8.	 Signs. As of the Second Expansion Premises Commencement Date,
Section 38 of the Lease is hereby amended to include the following language: 

“Subject to the signage rights of any tenants of the Project existing as of the date of the Fourth Amendment, Tenant shall
have the non-exclusive right to display, at Tenant’s cost and expense, up to two (2) signs bearing Tenant’s name and/or logo (“Building Signs”) at locations on the
Building reasonably acceptable to Landlord and Tenant. Notwithstanding the foregoing, Tenant acknowledges and agrees that the Building Signs including, without limitation, the size, color and type, shall be subject to Landlord’s prior written
approval, which shall not be unreasonably withheld, shall be consistent with Landlord’s signage program at the Project and shall be subject to any and all other required approvals and applicable Legal Requirements. Tenant shall be responsible,
at Tenant’s sole cost and expense, for the maintenance of the Building Signs, for the removal of the Building Signs at the expiration or earlier termination of this Lease and for the repair of all damage resulting from such removal. 

Tenant shall have the right, at Tenant’s sole cost and expense, to display signage bearing Tenant’s name and logo in
a location within the main Building lobby reasonably acceptable to Landlord and Tenant where such signage will be visible through the glass entry doors of the main Building lobby, provided that such signage, including, without limitation, the size,
color and type, shall be subject to Landlord’s reasonable approval and applicable Legal Requirements.” 
 Notwithstanding anything
contained in the Lease or the Fourth Amendment Work Letter, Tenant may apply a portion of the TI Allowance to the cost of installing the Building Signs and other signage to which Tenant is entitled pursuant to this
Section 8. 
  

	9.	 Extension Right. As of the Second Expansion Premises Commencement Date,
Section 40 of the Lease is hereby deleted in its entirety and replaced with the following: 

“40. Right to Extend Term. Tenant shall have the right to extend the Term of the Lease with respect to the entire Premises
only upon the following terms and conditions: 

  
 4 

 (a) Extension Rights. Tenant shall have 2 rights (each, an
“Extension Right”) to extend the term of this Lease for 7 years each (each, an “Extension Term”) on the same terms and conditions as this Lease (other than with respect to Base Rent and any work letters) by
giving Landlord written notice of its election to exercise the Extension Right at least 12 months and not more than 15 months prior to the expiration of the Base Term of the Lease or the expiration of the prior Extension Term, as applicable. 

Upon the commencement of an Extension Term, Base Rent shall be payable at the Market Rate (as defined below). Base Rent shall thereafter be
adjusted on each annual anniversary of the commencement of such Extension Term by the Rent Adjustment Percentage. As used herein, “Market Rate” shall mean the rate that comparable landlords of comparable buildings have
accepted in current transactions from non-equity (i.e., not being offered equity in the buildings) and nonaffiliated tenants of similar financial strength for space of comparable size, quality (including all
Tenant Improvements, Alterations and other improvements) and floor height in comparable laboratory/office buildings in the South Lake Union area of Seattle, with the determination of the Market Rate to take into account all relevant factors,
including term, use, tenant inducements, views, parking costs, leasing commissions, allowances or concessions, if any. Notwithstanding the foregoing, the Market Rate shall in no event be less than the Base Rent payable as of the date immediately
preceding the commencement of such Extension Term increased by the Rent Adjustment Percentage multiplied by such Base Rent. In addition, Landlord may impose a market rent for the parking rights provided hereunder. 

If, on or before the date which is 270 days prior to the expiration of the Base Term of this Lease or the expiration of the prior Extension
Term, as applicable, Tenant has not agreed with Landlord’s determination of the Market Rate during the applicable Extension Term after negotiating in good faith, Tenant shall be deemed to have elected arbitration as described in
Section 40(b). Tenant acknowledges and agrees that, if Tenant has elected to exercise an Extension Right by delivering notice to Landlord as required in this Section 40(a), Tenant shall have no
right thereafter to rescind or elect not to extend the term of the Lease for such Extension Term. 
 (b) Arbitration.

 (i) Within 10 days of Tenant’s notice to Landlord of its election (or deemed election) to arbitrate Market Rate, each
party shall deliver to the other a proposal containing the Market Rate that the submitting party believes to be correct (“Extension Proposal”). If either party fails to timely submit an Extension Proposal, the other
party’s submitted proposal shall determine the Base Rent for the first year of the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after delivery of the last Extension Proposal and
make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate. If Landlord and Tenant are unable to agree upon a single Arbitrator, then each shall, by written notice delivered to the other within
10 days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal shall determine the Base Rent for the first year of the Extension Term. The 2
Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If the 2 Arbitrators so selected cannot agree on the selection of the third Arbitrator within the time above specified, then either party, on
behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the Premises are located, upon 10 days prior written notice to the other party of
such intent. 
 (ii) The decision of the Arbitrator(s) shall be made within 30 days after the appointment of a single
Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and binding upon the parties.
Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate for the 

  
 5 

 first year of the Extension Term is not determined by the first day of the Extension Term,
then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by the Rent Adjustment Percentage until such determination is made. After the determination of the Market
Rate, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Market Rate for the Extension Term. 

(iii) An “Arbitrator” shall be any person appointed by or on behalf of either party or appointed
pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech industrial real estate in the
greater Seattle metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of high tech or life sciences space in the greater Seattle
metropolitan area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and disinterested. 

(c) Rights Personal. The Extension Rights are personal to Tenant and are not assignable without Landlord’s
consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease, except that they may be assigned in connection with any Permitted
Assignment of this Lease. 
 (d) Exceptions. Notwithstanding anything set forth above to the contrary, the
Extension Rights shall, at Landlord’s option, not be in effect and Tenant may not exercise either of the Extension Rights: 
 (i) during
any period of time that Tenant is in Default under any provision of this Lease; or 
 (ii) if Tenant has been in Default under any provision
of this Lease 3 or more times, whether or not the Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise an Extension Right, whether or not the Defaults are cured. 

(e) No Extensions. The period of time within which any Extension Right may be exercised shall not be extended or
enlarged by reason of Tenant’s inability to exercise the Extension Rights. 
 (f) Termination. The
Extension Rights, at Landlord’s option, shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of an Extension Right, if, after such exercise, but prior to the commencement date of an Extension
Term, (i) Tenant fails to timely cure any default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of an Extension Right to the date of the commencement of the
Extension Term, whether or not such Defaults are cured.” 
  

	10.	 Expansion Right. 

a. Generally. Tenant shall have the one-time right, but not the obligation, to expand the
Premises to include the Third Floor Option Space upon the terms and conditions set forth in this Section 10 (“Third Floor Expansion Right”). Tenant shall be entitled to exercise its right
under this Section 10 by delivery of written notice to Landlord of such election on or before June 1, 2016 (“Expansion Notice”). If Tenant elects to lease the Third Floor Option Space by timely
delivering an Expansion Notice to Landlord, Tenant shall be deemed to agree to lease the Third Floor 

  
 6 

 Option Space on the same general terms and conditions as the Lease, except that (i) the
commencement date of the Lease with respect to the Third Floor Option Space shall be August 1, 2016 (the “Third Floor Option Space Commencement Date”), (ii) commencing on the Third Floor Option Space Commencement Date, Tenant
shall pay Base Rent for the Third Floor Option Space equal to $30.00 per rentable square foot of the Third Floor Option Space per year, (iii) Base Rent payable for the Third Floor Option Space shall be increased on each annual anniversary of
the Third Floor Option Space Commencement Date (each, a “Third Floor Option Space Adjustment Date”), by multiplying the Base Rent payable for the Third Floor Option Space immediately before the Third Floor Option Space Adjustment
Date by 2.5% and adding the resulting amount to the Base Rent payable for the Third Floor Option Space immediately before such Third Floor Option Space Adjustment Date, (iv) commencing on the Third Floor Commencement Date, Tenant’s Share
of Operating Expenses shall be increased to 48.53%, (v) commencing on the Third Floor Option Space Commencement Date, Tenant shall commence paying Tenant’s Share of Operating Expenses with respect to the Third Floor Option Space,
(vi) Landlord shall provide to Tenant a tenant improvement allowance in the amount of $50.00 per rentable square foot of the Third Floor Option Space (“Third Floor Option Space Allowance”) for the construction of tenant
improvements in the Premises pursuant to the terms of a work letter substantially in the form of the Fourth Amendment Work Letter as it relates to the Tenant Improvements, and (vii) Tenant shall be entitled, subject to the terms of
Section 10 of the original Lease, to its pro rata share of parking spaces with respect to the Third Floor Option Space (“Third Floor Parking Spaces”), which Third Floor Parking Spaces shall be
(1) subject to the payment of the market rate for each Third Floor Parking Space, as reasonably determined by Landlord from time to time, which as of the Third Floor Option Space Commencement Date shall be $150 per month for each Third Floor
Parking Space plus applicable taxes, and (2) located among the parking areas serving the Project, as reasonably determined by Landlord. If Tenant does not timely deliver an Expansion Notice pursuant to this
Section 10(a), Tenant shall be deemed to have forever waived its right to expand the Premises pursuant to this Section 10(a) to include the Third Floor Option Space and Tenant’s rights under
this Section 10(a) shall terminate and be of no further force or effect. 
 b. Amended Lease.
If (i) Tenant fails to timely deliver an Expansion Notice to Landlord, or (ii) after the expiration of a period of 10 business days after Landlord’s delivery to Tenant of a lease amendment for Tenants lease of the Third Floor Option
Space, no lease amendment acceptable to both parties in their respective reasonable discretion, has been executed, Tenant shall be deemed to have forever waived its right to lease the Third Floor Option Space. 

c. Exceptions. Notwithstanding the above, the Third Floor Expansion Right shall, at Landlord’s option, not be in
effect and may not be exercised by Tenant: 
 (i) during any period of time that Tenant is in Default under any provision of
the Lease; or 
 (ii) if Tenant has been in Default under any provision of the Lease 3 or more times, whether or not the
Defaults are cured, during the 12 month period prior to the date on which Tenant seeks to exercise the Third Floor Expansion Right. 

d. Termination. The Third Floor Expansion Right shall, at Landlord’s option, terminate and be of no further force or
effect even after Tenant’s due and timely exercise of the Third Floor Expansion Right, if, after such exercise, but prior to the commencement date of the lease of Third Floor Option Space, (i) Tenant fails to timely cure any default by
Tenant under the Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Third Floor Expansion Right to the date of the commencement of the lease of the Third Floor Option Space, whether or not
such Defaults are cured. 

  
 7 

 e. Rights Personal. The Third Floor Expansion Right is personal to
Tenant and is not assignable without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 

f. No Extensions. The period of time within which the Third Floor Expansion Right may be exercised shall not be extended
or enlarged by reason of Tenant’s inability to exercise the Third Floor Expansion Right. 
  

	11.	 Asbestos. 

a. Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials
(“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the location identified in Exhibit C attached to this First Amendment. 

b. Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (a) of this
Section 11 and understands that the purpose of such notification is to make Tenant and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order to
avoid or minimize any damage to or disturbance of such ACMs and/or PACMs. 

        CMR         

Tenant’s Initials 
 c.
Acknowledgement from Contractors/Employees. Tenant shall give Landlord at least 14 days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before
soliciting bids from any person to perform such services. Such notice shall identify or describe the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such
activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to determine whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of
such activities without Landlord’s prior written approval. Upon Landlord’s request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information
describing the presence of ACMs and/or PACMs within or about the Premises in the locations identified in Exhibit C prior to the commencement of such activities. Nothing in this Section 11 shall be deemed to expand
Tenant’s rights under the Lease or otherwise to conduct, authorize or permit any such activities. 
 (i) Removal of
thermal system insulation (“TSl”) and surfacing ACMs and PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or
fireproofing material); 
 (ii) Removal of ACMs or PACMs that are not TS; or surfacing ACMs or PACMs; or 

(iii) Repair and maintenance of operations that are likely to disturb ACMs or PACMs. 

 

	12.	 OFAC. Tenant and all beneficial owners of Tenant are currently (a) in compliance with and shall at
all times during the Term of the Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating thereto
(collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List or the Sectoral Sanctions
Identifications List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with
whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

  
 8 

	13.	 Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker,
agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Fourth Amendment and that no Broker brought about this transaction, other than Cushman & Wakefield, Flinn Ferguson
and Kidder Mathews. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other than Cushman & Wakefield, Flinn Ferguson and Kidder Mathews, claiming a commission or other
form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Fourth Amendment. Landlord shall be responsible for all commissions due to Flinn Ferguson and Kidder Mathews arising out of the execution of
this Fourth Amendment in accordance with the terms of separate written agreements between Landlord, on the one hand, and Cushman & Wakefield, Flinn Ferguson and Kidder Mathews, on the other hand. 

 

	14.	 Miscellaneous. 

a. This Fourth Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and
contemporaneous oral and written agreements and discussions. This Fourth Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This Fourth Amendment is binding upon and shall inure to the benefit of the parties hereto, and their respective successors and assigns.

 c. This Fourth Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when
taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other
counterpart identical thereto except having additional signature pages executed by other parties to this Fourth Amendment attached thereto. 

d. Except as amended and/or modified by this Fourth Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease
shall remain in full force and effect, unaltered and unchanged by this Fourth Amendment. In the event of any conflict between the provisions of this Fourth Amendment and the provisions of the Lease, the provisions of this Fourth Amendment shall
prevail. Whether or not specifically amended by this Fourth Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Fourth Amendment. 

[Signatures are on the next page.] 

  
 9 

 IN WITNESS WHEREOF, the parties hereto have executed this Fourth Amendment as of the
day and year first above written. 
  

							
	TENANT:
	
	ADAPTIVE BIOTECHNOLOGIES CORPORATION,
a Washington corporation
		
	By:	 	 /s/ Chad M. Robins

	Its:	 	CEO & President
	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
a Delaware limited liability company
		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership
		 	managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	 a Maryland corporation,
 general
partner

				
		 		 	By:	 	 /s/ Jackie Clem

		 		 	Its:	 	Senior Vice President, RE Legal Affairs

  
 10 

 

 

 

 

 

 

 

 

 EXHIBIT B 

Fourth Amendment Work Letter 

THIS FOURTH AMENDMENT WORK LETTER dated December 23, 2015 (this “Fourth Amendment Work Letter”) is made and
entered into by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation
(“Tenant”), and is attached to and made a part of the Lease Agreement dated July 21, 2011, as amended by that certain First Amendment to Lease dated as of August 26, 2011, as further amended by that certain Amended and
Restated Second Amendment to Lease dated as of June 30, 2014 (the “Second Amendment”), as further amended by that certain Third Amendment to Lease dated as of November 5, 2015, and as further amended by that certain
Fourth Amendment to Lease dated of even date herewith (the “Fourth Amendment”) (as amended, the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have
the meanings given them in the Lease. 
 1. General Requirements. 

(a) Tenant’s Authorized Representative. Tenant designates Andy Ament, Lorna Chang and Kathleen Determann (each
such individual acting alone, “Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Fourth Amendment Work Letter. Landlord shall not be obligated to respond to or act upon any
request, approval, inquiry or other communication (“Communication”) from or on behalf of Tenant in connection with this Fourth Amendment Work Letter unless such Communication is in writing from Tenant’s Representative.
Tenant may change any Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord. 

(b) Landlord’s Authorized Representative. Landlord designates John Cox and Jeff Graves (either such individual
acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Fourth Amendment Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry
or other Communication from or on behalf of Landlord in connection with this Fourth Amendment Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any
time upon not less than 5 business days advance written notice to Tenant. 
 (c) Architects, Consultants and Contractors.
Landlord and Tenant hereby acknowledge and agree that the architect (the “TI Architect”) for the Tenant Improvements (as defined in Section 2(a) below), the general contractor and any
subcontractors for the Tenant Improvements shall be selected by Tenant, subject to Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Landlord shall be named a third party beneficiary of any contract
entered into by Tenant with the TI Architect, any consultant, any contractor or any subcontractor, and of any warranty made by any contractor or any subcontractor. 

2. Tenant Improvements. 

(a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to any
portion of the Premises and the Building Signs desired by Tenant of a fixed and permanent nature performed after the date of the Fourth Amendment. Other than funding the TI Allowance (as defined below) as provided herein, Landlord shall not
have any obligation whatsoever with respect to the finishing of the Premises for Tenant’s use and occupancy. 
 (b) Tenant’s
Space Plans. Tenant shall deliver to Landlord schematic drawings and outline specifications (the “TI Design Drawings”) detailing Tenant’s requirements for the Tenant Improvements within 15 days of the date
hereof. Not more than 10 days thereafter, Landlord shall deliver to Tenant the 

  
 B-1 

 written objections, questions or comments of Landlord and the TI Architect with regard to the TI Design
Drawings. Tenant shall cause the TI Design Drawings to be revised to address such written comments and shall resubmit said drawings to Landlord for approval within 10 days thereafter. Such process shall continue until Landlord has approved the TI
Design Drawings. 
 (c) Working Drawings. Not later than 15 business days following the approval of the TI Design Drawings by
Landlord, Tenant shall cause the TI Architect to prepare and deliver to Landlord for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction
Drawings shall be prepared substantially in accordance with the TI Design Drawings. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Landlord shall
deliver its written comments on the TI Construction Drawings to Tenant not later than 10 business days after Landlord’s receipt of the same; provided, however, that Landlord may not disapprove any matter that is consistent with the TI Design
Drawings. Tenant and the TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Landlord how Tenant proposes to respond to such comments. Any disputes in connection with such comments
shall be resolved in accordance with Section 2(d), hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the TI Design Drawings, Landlord shall approve the TI Construction Drawings submitted
by Tenant. Once approved by Landlord, subject to the provisions of Section 4 below, Tenant shall not materially modify the TI Construction Drawings except as may be reasonably required in connection with the issuance of the
TI Permit (as defined in Section 3(a) below). 
 (d) Approval and Completion. If any dispute
regarding the design of the Tenant Improvements is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant Improvements, provided
(i) Tenant acts reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all costs and expenses resulting from any such
decision by Tenant shall be payable out of the TI Fund (as defined in Section 5(d) below), and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building
Systems (in which case Landlord shall make the final decision). Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in
Section 4 hereof. 
 3. Performance of the Tenant Improvements. 

(a) Commencement and Permitting of the Tenant Improvements. Tenant shall commence construction of the Tenant Improvements upon
obtaining and delivering to Landlord a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Landlord. The cost of obtaining the TI
Permit shall be payable from the TI Fund. Landlord shall assist Tenant in obtaining the TI Permit. Prior to the commencement of the Tenant Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s contractors
(including the TI Architect), and certificates of insurance from any contractor performing any part of the Tenant Improvement evidencing industry standard commercial general liability, automotive liability, “builder’s risk”, and
workers’ compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the general
contractor’s liability coverages required above. 
 (b) Selection of Materials, Etc. Where more than one type of material
or structure is indicated on the TI Construction Drawings approved by Tenant and Landlord, the option will be within Tenant’s reasonable discretion if the matter concerns the Tenant improvements, and within Landlord’s sole and absolute
subjective discretion if the matter concerns the structural components of the Building or any Building Systems. 
 (c) Tenant
Liability. During the Term of the Lease, Tenant agrees to enforce its rights under any contract Tenant enters into with the TI Architect or any contractor with respect to the Tenant Improvements and enforce any warranties thereunder with
respect to correcting any deficiencies or defects in the Tenant Improvements. 

  
 B-2 

 (d) Substantial Completion. Tenant shall substantially complete or cause to be
substantially completed the Tenant Improvements in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a
non-material nature which do not interfere with the use of the Premises (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of the
Tenant Improvements, Tenant shall require the TI Architect and the general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects
(“AIA”) document G704. For purposes of this Fourth Amendment Work Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or
to obtain or to comply with any required permit (including the TI Permit); (ii) to comport with good design, engineering, and construction practices which are not material; or (iii) to make reasonable adjustments for field deviations or
conditions encountered during the construction of the Tenant Improvements. 
 4. Changes. Following the approval by Landlord
of the TI Design Drawings, any changes to the Tenant improvements desired by Tenant that would affect the Building structure or Building Systems (“Changes”) shall be subject to the written approval of Landlord, which approval may be
granted or withheld in Landlord’s sole and absolute discretion. Any such Changes requested by Tenant, shall be requested and instituted in accordance with the provisions of this Section 4. 

(a) Tenant’s Right to Request Changes. If Tenant shall request Changes, Tenant shall request such Changes by notifying
Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by
Tenant’s Representative. Landlord shall review and approve or disapprove such Change Request within 10 business days thereafter, provided that Landlord’s approval shall not be unreasonably withheld, conditioned or delayed. 

(b) Implementation of Changes. If Landlord approves such Change and Tenant deposits with Landlord any Excess TI Costs (as defined
in Section 5(d) below) required in connection with such Change, Tenant may cause the approved Change to be instituted. If any TI Permit modification or change is required as a result of such Change, Tenant shall promptly
provide Landlord with a copy of such TI Permit modification or change. 
 5. Costs. 

(a) Budget For Tenant Improvements. Before the commencement of construction of the Tenant Improvements, Tenant shall obtain a
detailed breakdown, by trade, of the costs incurred or that will be incurred, in connection with the design and construction of the Tenant Improvements (the “Budget”), and deliver a copy of the Budget to Landlord for Landlord’s
approval, which shall not be unreasonably withheld or delayed_ The Budget shall be based upon the TI Construction Drawings approved by Landlord. The Budget shall include a payment to Landlord of administrative rent (“Administrative
Rent”) equal to 1% of the TI Costs (as hereinafter defined), not to exceed $37,650 in the aggregate, for monitoring and inspecting the construction of the Tenant Improvements, which sum shall be payable from the TI Fund. Such Administrative
Rent shall include, without limitation, all out-of-pocket costs, expenses and fees incurred by or on behalf of Landlord arising from, out of, or in connection with, such
monitoring of the construction of the Tenant Improvements. If the Budget is greater than the TI Allowance, Tenant shall deposit with Landlord the difference, in cash, prior to the commencement of construction of the Tenant Improvements, for
disbursement by Landlord as described in Section 5(d). 

  
 B-3 

 (b) TI Allowance. Landlord shall provide to Tenant a tenant improvement
allowance (collectively, the “TI Allowance”) as follows: 
 1. a “Tenant Improvement
Allowance” in the maximum amount of $138.93 per rentable square foot in the Second Expansion Premises, or $3,903,933 in the aggregate, which is included in the Base Rent set forth in the Lease; and 

2. an “Additional Tenant Improvement Allowance” in the maximum amount of $50.00 per rentable square
foot in the Second Expansion Premises, or $1,405,000 in the aggregate, which shall, to the extent used, result in Additional Rent as set forth in the Lease. 

The TI Allowance shall be disbursed in accordance with this Fourth Amendment Work Letter. Tenant shall have no right to the use or benefit
(including any reduction to Base Rent) of any portion of the TI Allowance not required for the design and construction of (i) the Tenant Improvements described in the TI Construction Drawings approved pursuant to
Section 2(d) or (ii) any Changes pursuant to Section 4. Tenant shall have no right to any portion of the TI Allowance that is not disbursed before the last day of the month that is 12 months
after the Second Expansion Premises Commencement Date. 
 (c) Costs Includable in TI Fund. The TI Fund shall be used solely for
the payment of design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the cost of electrical power and other utilities used in connection with the construction of the
Tenant Improvements, the cost of preparing the TI Design Drawings and the TI Construction Drawings, all costs set forth in the Budget, including Landlord’s Administrative Rent, and the cost of Changes (collectively, “TI
Costs”). Notwithstanding anything to the contrary contained herein, the TI Fund shall not be used to purchase any furniture, personal property or other non-Building system materials or equipment,
including, but not limited to, Tenant’s voice or data cabling, non-ducted biological safety cabinets and other scientific equipment not incorporated into the Tenant Improvements 

(d) Excess TI Costs. Landlord shall have no obligation to bear any portion of the cost of any of the Tenant Improvements except
to the extent of the TI Allowance. If at any time and from time-to-time, the remaining TI Costs under the Budget exceed the remaining unexpended TI Allowance, Tenant
shall deposit with Landlord, as a condition precedent to Landlord’s obligation to fund the TI Allowance, 100% of the then current TI Cost in excess of the remaining T1 Allowance (“Excess TI Costs”). If Tenant fails to deposit,
or is late in depositing any Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the Default Rate and the right to
assess a late charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. The TI Allowance and Excess TI Costs is herein referred to as the “TI Fund.” Funds deposited by Tenant shall be the first thereafter disbursed to pay TI Costs. Notwithstanding anything to the contrary set forth in this Section 5(d), Tenant shall
be fully and solely liable for TI Costs and the cost of Minor Variations in excess of the TI Allowance, If upon Substantial Completion of the Tenant Improvements and the payment of all sums due in connection therewith there remains any undisbursed
portion of the TI Fund, Tenant shall be entitled to such undisbursed Tl Fund solely to the extent of any Excess TI Costs deposit Tenant has actually made with Landlord. 

(e) Payment for TI Costs. During the course of design and construction of the Tenant Improvements, Landlord shall reimburse
Tenant for TI Costs once a month against a draw request in Landlord’s standard form, containing evidence of payment of such TI Costs by Tenant and such certifications, lien waivers (including a conditional lien release for each progress payment
and unconditional lien releases for the prior month’s progress payments), inspection reports and other matters as Landlord reasonably and customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days
following receipt of such draw request. Upon completion of the Tenant Improvements (and prior to any final disbursement of the TI Fund), Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and first
tier subcontractors who did the work and final, unconditional lien waivers from all such contractors and first tier subcontractors; (ii) as-built plans (one copy in print format and two copies in
electronic CAD format) for such Tenant Improvements, (iii) a certification of substantial completion in Form AlA G704, (iv) a certificate or temporary of occupancy for the Premises (or an equivalent approval); and (v) copies of all
operation and maintenance manuals and warranties affecting the Premises. 

  
 B-4 

 6. Miscellaneous. 

(a) Consents. Whenever consent or approval of either party is required under this Fourth Amendment Work Letter, that party shall
not unreasonably withhold, condition or delay such consent or approval, except as may be expressly set forth herein to the contrary. 
 (b)
Modification. No modification, waiver or amendment of this Fourth Amendment Work Letter or of any of its conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

(c) No Default Funding. In no event shall Landlord have any obligation to fund any portion of the TI Allowance during any period
that Tenant is in Default under the Lease. 

  
 B-5 

 Exhibit C 

Asbestos Disclosure 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 1551 Eastlake Avenue, Seattle, WA (“Building”) and in
accordance with Washington Administrative Code, Chapter 296-62-07721. 

Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building products
were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. 

An asbestos survey of the Building has determined that ACMs and/or materials that might contain ACMs, referred to as presumed asbestos-containing materials or
PACMs, are present within or about the Premises as follows: 
  

			
	 Material Description
	  	 Material Location

	Floor Mastic (not covered by floor tile)	  	Various locations within the parking garage
	Flooring Material and Mastic beneath new floor tile (PALM)	  	Landings of stairwells #1 and #2

 Because AGMs and PACMs are present and may continue to be present within or about the Building, we have hired an independent
environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the
Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate
personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M Program describes the risks associated with
asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically
occur unless (1) the ACMs are in a deteriorating condition, or (2) the AGMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the
lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. 

The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be
aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. 

The O&M Program is available for review during regular business hours at our office located at 1600 Fairview Avenue East, Suite 100, Seattle WA 98102.

  
 C-1 

 

 

  

 

 

  

 

 

  

 FIFTH AMENDMENT TO LEASE 

THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is made as of June 6, 2016, by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation (“Tenant”). 

RECITALS 
 A. Landlord and
Tenant are now parties to that certain Lease Agreement dated as of July 21, 2011, as amended by that certain First Amendment to Lease dated as of August 26, 2011, as further amended by that certain Amended and Restated Second Amendment to
Lease dated as of June 30, 2014, as further amended by that certain Third Amendment to Lease dated as of November 5, 2015 (the “Third Amendment”), and as further amended by that certain Fourth Amendment to Lease
dated as of December 23, 2015 (the “Fourth Amendment”) (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises consisting of approximately 48,424 rentable square feet (“Current
Premises”) on the second and third floors of that certain building located at 1551 Eastlake Avenue, Seattle, Washington. The Current Premises are more particularly described in the Lease. Capitalized terms used herein without definition
shall have the meanings defined for such terms in the Lease. 
 B. Landlord and Tenant desire, subject to the terms and conditions set forth
below, to amend the Lease to, among other things, expand the size of the Current Premises by adding that portion of the third floor of the Building consisting of approximately 8,594 rentable square feet, as shown on Exhibit A attached to this
Fifth Amendment (“Third Expansion Premises”). 
 NOW, THEREFORE, in consideration of the foregoing Recitals, which
are incorporated herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows:

  

	1.	 Third Expansion Premises. In addition to the Current Premises, commencing on the Third
Expansion Premises Commencement Date (as defined below), Landlord leases to Tenant, and Tenant leases from Landlord, the Third Expansion Premises. 

  

	2.	 Delivery. As of the date of this Fifth Amendment, Tenant is occupying the Third Expansion
Premises pursuant to the terms of the Third Amendment. The “Third Expansion Premises Commencement Date” shall be the date that is 1 business day after the mutual execution and delivery of this Fifth Amendment by the parties,
Tenant’s occupancy of the Third Expansion Premises shall be pursuant to the terms of this Fifth Amendment (and no longer pursuant to the terms of the Third Amendment) as of the Third Expansion Premises Commencement Date. The “Third
Expansion Premises Rent Commencement Date” shall be August 1, 2016. Upon the request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Third Expansion Premises Commencement Date and the Third
Expansion Premises Rent Commencement Date in substantially the form of the “Acknowledgement of Commencement Date” attached to the Lease as Exhibit D; provided, however, Tenant’s failure to execute and
deliver such acknowledgment shall not affect either party’s rights hereunder. 

 Except as set forth in the Fifth
Amendment Work Letter: (i) Landlord shall have no obligation for any defects in the Third Expansion Premises; and (ii) Tenant’s occupancy of the Third Expansion Premises immediately prior to the Third Expansion Premises Commencement
Date shall be conclusive evidence that Tenant accepts the Third Expansion Premises and that the Third Expansion Premises were in good condition at the time possession was taken. 

 

  
 1 

 Tenant agrees and acknowledges that, except as otherwise expressly set forth in this Fifth
Amendment or in the Lease, neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of all or any portion of the Third Expansion Premises, and/or the suitability of the Third Expansion Premises
for the conduct of Tenant’s business, and Tenant waives any implied warranty that the Third Expansion Premises are suitable for the Permitted Use. 
  

	3.	 Premises and Rentable Area of Premises. Commencing on the Third Expansion Premises Commencement
Date, the defined terms “Premises” and “Rentable Area of Premises” on page 1 of the Lease shall be deleted in their entirety and replaced with the following: 

“Premises: That portion of the Building containing approximately 57,018 rentable square feet, consisting of (i) that certain
portion of the second floor containing approximately 7,724 rentable square feet (the “Original Premises”), (ii) that certain portion of the second floor containing approximately 12,600 rentable square feet (the “Expansion
Premises”), (iii) those certain portions of the second and third floors containing approximately 28,100 rentable square feet (the “Second Expansion Premises”), and (iv) that certain portion of the third floor
consisting of approximately 8,594 rentable square feet (the “Third Expansion Premises”), all as shown on Exhibit A.” 

“Rentable Area of Premises: 57,018 sq. ft.” 

As of the Third Expansion Premises Commencement Date, Exhibit A to the Lease shall be amended to include the Third Expansion Premises as
shown on Exhibit A attached to this Fifth Amendment. 
  

	4.	 Base Term Commencing on the Third Expansion Premises Commencement Date, the defined term
“Base Term” on page 1 of the Lease is deleted in its entirety and replaced with the following: 

“Base Term: Commencing (i) with respect to the Original Premises on the Commencement Date, (ii) with respect to the
Expansion Premises on the Expansion Premises Commencement Date, (iii) with respect to the Second Expansion Premises on the Second Expansion Premises Commencement Date, and (iv) with respect to the Third Expansion Premises on the Third
Expansion Premises Commencement Date, and ending with respect to the entire Premises on June 1, 2023.” 
  

	5.	 Base Rent. 

a. Current Premises. Tenant shall continue to pay Base Rent for the Current Premises as provided for in the Lease. 

b. Third Expansion Premises. Commencing on the Third Expansion Premises Rent Commencement Date, Tenant shall pay Base Rent for the Third
Expansion Premises at the rate of $30.00 per rentable square foot of the Third Expansion Premises per year. Base Rent payable for the Third Expansion Premises shall be increased on each annual anniversary of the Third Expansion Premises Rent
Commencement Date (each, a “Third Expansion Premises Adjustment Date”), by multiplying the Base Rent payable for the Third Expansion Premises immediately before the Third Expansion Premises Adjustment Date by 2.5% and adding
the resulting amount to the Base Rent payable for the Third Expansion Premises immediately before the Third Expansion Premises Adjustment Date. 
  

	6.	 Tenant’s Share. Commencing on the Third Expansion Premises Commencement Date, the
defined term “Tenant’s Share of Operating Expenses” on page 1 of the Lease shall be deleted in its entirety and replaced with the following: 

“Tenant’s Share of Operating Expenses: 48.53%” 

  
 2 

	7.	 Parking. Subject to all matters of record, Force Majeure, a Taking and the exercise by
Landlord of its rights hereunder, Landlord shall make available to Tenant and Tenant shall, in addition to the parking spaces that Tenant has the right to use pursuant to Section 10 of the original Lease, the Expansion
Premises Parking Spaces which Tenant has the right to use pursuant to Section 2 of the Second Amendment, and the Second Expansion Premises Parking Spaces which Tenant has a right to use pursuant to Section 7 of the
Fourth Amendment, be entitled to use, subject to the terms of Section 10 of the original Lease, Tenant’s pro rata share of parking spaces with respect to the Third Expansion Premises. As of the Third Expansion Premises
Commencement Date, Tenant’s pro rata share of parking spaces with respect to the Third Expansion Premises shall be equal to 2 parking spaces per 1,000 rentable square feet of the Third Expansion Premises (“Third Expansion Premises
Parking Spaces”). The Third Expansion Premises Parking Spaces shall be allocated as reasonably determined by Landlord among the Underground Parking, Surface Parking, Northeast Parking and Offsite Parking. Tenant’s use of the
Third Expansion Premises Parking Spaces shall be subject to the payment by Tenant of the market rate for each Third Expansion Premises Parking Space, as reasonably determined by Landlord from time to time, which as of the date of this Fifth
Amendment shall be $150 per month for each Third Expansion Premises Parking Space plus applicable taxes. 

  

	8.	 Tenant Improvements. Tenant shall have the right to construct certain Tenant Improvements in the
Premises, including the Third Expansion Premises, pursuant to the Fifth Amendment Work Letter attached hereto as Exhibit B. 

  

	9.	 OFAC. Tenant and all beneficial owners of Tenant are currently (a) in
compliance with and shall at all times during the Term of the Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive
order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions
Evaders List or the Sectoral Sanctions Identifications List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation,
and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

  

	10.	 Brokers. Landlord and Tenant each represents and warrants that it has not dealt
with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Fifth Amendment and that no Broker brought about this transaction, other than Cushman & Wakefield, Flinn
Ferguson and Kidder Mathews. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other than Cushman & Wakefield, Flinn Ferguson and Kidder Mathews, claiming a commission
or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Fifth Amendment. Landlord shall be responsible for all commissions due to Flinn Ferguson and Kidder Mathews arising out of the
execution of this Fifth Amendment in accordance with the terms of separate written agreements between Landlord, on the one hand, and Cushman & Wakefield, Flinn Ferguson and Kidder Mathews, on the other hand. 

 

	11.	 Miscellaneous. 

a. This Fifth Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior
and contemporaneous oral and written agreements and discussions. This Fifth Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This Fifth Amendment is binding upon and shall inure to the benefit of the parties hereto, and their respective successors and
assigns. 

  
 3 

 c. This Fifth Amendment may be executed in any number of counterparts, each of which shall
be deemed an original, but all of which when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such
signature page is attached to any other counterpart identical thereto except having additional signature pages executed by other parties to this Fifth Amendment attached thereto. 

d. Except as amended and/or modified by this Fifth Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall
remain in full force and effect, unaltered and unchanged by this Fifth Amendment. In the event of any conflict between the provisions of this Fifth Amendment and the provisions of the Lease, the provisions of this Fifth Amendment shall prevail.
Whether or not specifically amended by this Fifth Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Fifth Amendment. 

[Signatures are on the next page.] 

  
 4 

 IN WITNESS WHEREOF, the parties hereto have executed this Fifth Amendment as of the
day and year first above written. 
  

							
	TENANT:
	
	ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation
		
	By:	 	 /s/ Chad M. Robins

	Its:	 	CEO & President
	
	LANDLORD:
	
	ARE-SEATTLE NO. 11, LLC,
a Delaware limited liability company
		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership
		 	managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation, general partner
				
		 		 	By:	 	 /s/ Jackie Clem

		 		 	Its:	 	Senior Vice President, RE Legal Affairs

  
 5 

 

 

 

 

 

 

 EXHIBIT B 

Fifth Amendment Work Letter 

THIS FIFTH AMENDMENT WORK LETTER dated May     , 2016 (this “Fifth Amendment Work Letter”) is made and
entered into by and between ARE-SEATTLE NO. 11, LLC, a Delaware limited liability company (“Landlord”), and ADAPTIVE BIOTECHNOLOGIES CORPORATION, a Washington corporation
(“Tenant”), and is attached to and made a part of the Lease Agreement dated July 21, 2011, as amended by that certain First Amendment to Lease dated as of August 26, 2011, as further amended by that certain Amended and
Restated Second Amendment to Lease dated as of June 30, 2014 (the “Second Amendment”), as further amended by that certain Third Amendment to Lease dated as of November 5, 2015, as further amended by that certain Fourth Amendment
to Lease dated as of December 23, 2015, and as further amended by that certain Fifth Amendment to Lease dated of even date herewith (the “Fifth Amendment”) (as amended, the “Lease”), by and between Landlord and
Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
 1. General
Requirements. 
 (a) Tenant’s Authorized Representative. Tenant designates Andy Ament, Chad Cohen and Brian Finrow
(each such individual acting alone, “Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Fifth Amendment Work Letter. Landlord shall not be obligated to respond to or act upon any
request, approval, inquiry or other communication (“Communication”) from or on behalf of Tenant in connection with this Fifth Amendment Work Letter unless such Communication is in writing from Tenant’s Representative.
Tenant may change any Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord. 
 (b)
Landlord’s Authorized Representative. Landlord designates John Cox (“Landlord’s Representative”) as the only person authorized to act for Landlord pursuant to this Fifth Amendment Work Letter. Tenant
shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication from or on behalf of Landlord in connection with this Fifth Amendment Work Letter unless such Communication is in writing from Landlord’s
Representative. Landlord may change or add an additional Landlord’s Representative at any time upon not less than 5 business days advance written notice to Tenant. 

(c) Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that the architect (the “TI
Architect”) for the Tenant Improvements (as defined in Section 2(a) below), the general contractor and any subcontractors for the Tenant Improvements shall be selected by Tenant, subject to Landlord’s
approval, which approval shall not be unreasonably withheld, conditioned or delayed. Landlord shall be named a third party beneficiary of any contract entered into by Tenant with the TI Architect, any consultant, any contractor or any subcontractor,
and of any warranty made by any contractor or any subcontractor. 
 2. Tenant Improvements. 

(a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the
Premises desired by Tenant of a fixed and permanent nature. Other than funding the Tenant Improvement Allowance (as defined below) as provided herein, Landlord shall not have any obligation whatsoever with respect to the finishing of the Premises
(including the Third Expansion Premises) for Tenant’s use and occupancy. 
 (b) Tenant’s Space Plans. Tenant shall
deliver to Landlord schematic drawings and outline specifications (the “TI Design Drawings”) detailing Tenant’s requirements for the Tenant Improvements within 15 days of the date hereof. Not more than 10 days thereafter,
Landlord shall deliver to Tenant the written objections, questions or comments of Landlord and the TI Architect with regard to the TI Design Drawings. Tenant shall cause the TI Design Drawings to be revised to address such written comments and shall
resubmit said drawings to Landlord for approval within 10 days thereafter. Such process shall continue until Landlord has approved the TI Design Drawings. 

  
 B-1 

 (c) Working Drawings. Not later than 15 business days following the approval of the
TI Design Drawings by Landlord, Tenant shall cause the TI Architect to prepare and deliver to Landlord far review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”),
which TI Construction Drawings shall be prepared substantially in accordance with the TI Design Drawings. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant
Improvements. Landlord shall deliver its written comments on the T1 Construction Drawings to Tenant not later than 10 business days after Landlord’s receipt of the same; provided, however, that Landlord may not disapprove any matter that is
consistent with the TI Design Drawings. Tenant and the TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Landlord how Tenant proposes to respond to such comments. Any disputes in
connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the TI Design Drawings, Landlord shall approve
the TI Construction Drawings submitted by Tenant. Once approved by Landlord, subject to the provisions of Section 4 below, Tenant shall not materially modify the TI Construction Drawings except as may be reasonably required
in connection with the issuance of the TI Permit (as defined in Section 3(a) below). 
 (d) Approval and
Completion. If any dispute regarding the design of the Tenant Improvements is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the
Tenant Improvements, provided (i) Tenant acts reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all costs and expenses
resulting from any such decision by Tenant shall be payable out of the TI Fund (as defined in Section 5(d) below), and (iii) Tenant’s decision will not affect the base Building, structural components of the
Building or any Building Systems (in which case Landlord shall make the final decision). Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in
Section 4 hereof. 
 3. Performance of the Tenant Improvements. 

(a) Commencement and Permitting of the Tenant Improvements. Tenant shall commence construction of the Tenant Improvements upon obtaining
and delivering to Landlord a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Landlord. The cost of obtaining the TI Permit shall be
payable from the T1 Fund. Landlord shall assist Tenant in obtaining the TI Permit. Prior to the commencement of the Tenant Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s contractors (including the TI
Architect), and certificates of insurance from any contractor performing any part of the Tenant Improvement evidencing industry standard commercial general liability, automotive liability, “builder’s risk”, and workers’
compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the general
contractor’s liability coverages required above. 
 (b) Selection of Materials, Etc. Where more than one type of material or
structure is indicated on the TI Construction Drawings approved by Tenant and Landlord, the option will be within Tenant’s reasonable discretion if the matter concerns the Tenant Improvements, and within Landlord’s sole and absolute
subjective discretion if the matter concerns the structural components of the Building or any Building Systems. 
 (c) Tenant
Liability. During the Term of the Lease, Tenant agrees to enforce its rights under any contract Tenant enters into with the TI Architect or any contractor with respect to the Tenant Improvements and enforce any warranties thereunder with respect
to correcting any deficiencies or defects in the Tenant Improvements. 

  
 B-2 

 (d) Substantial Completion. Tenant shall substantially complete or cause to be
substantially completed the Tenant Improvements in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a
non-material nature which do not interfere with the use of the Premises (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of
the Tenant Improvements, Tenant shall require the TI Architect and the general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects
(“AlA”) document G704. For purposes of this Fifth Amendment Work Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or
to obtain or to comply with any required permit (including the TI Permit); (ii) to comport with good design, engineering, and construction practices which are not material; or (iii) to make reasonable adjustments for field deviations or
conditions encountered during the construction of the Tenant Improvements. 
 4. Changes. Following the approval by Landlord of
the TI Design Drawings, any changes to the Tenant Improvements desired by Tenant that would affect the Building structure or Building Systems (“Changes”) shall be subject to the written approval of Landlord, which approval
may be granted or withheld in Landlord’s sole and absolute discretion. Any such Changes requested by Tenant, shall be requested and instituted in accordance with the provisions of this Section 4. 

(a) Tenant’s Right to Request Changes. If Tenant shall request Changes, Tenant shall request such Changes by notifying
Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by
Tenant’s Representative. Landlord shall review and approve or disapprove such Change Request within 10 business days thereafter, provided that Landlord’s approval shall not be unreasonably withheld, conditioned or delayed. 

(b) Implementation of Changes. If Landlord approves such Change and Tenant deposits with Landlord any Excess TI Costs (as defined
in Section 5(d) below) required in connection with such Change, Tenant may cause the approved Change to be instituted. If any TI Permit modification or change is required as a result of such Change, Tenant shall
promptly provide Landlord with a copy of such TI Permit modification or change. 
 5. Costs. 

(a) Budget For Tenant Improvements. Before the commencement of construction of the Tenant Improvements, Tenant shall obtain a
detailed breakdown, by trade, of the costs incurred or that will be incurred, in connection with the design and construction of the Tenant Improvements (the “Budget”), and deliver a copy of the Budget to Landlord for Landlord’s
approval, which shall not be unreasonably withheld or delayed. The Budget shall be based upon the TI Construction Drawings approved by Landlord. The Budget shall include a payment to Landlord of administrative rent (“Administrative
Rent”) equal to 1% of the TI Allowance (as hereinafter defined) for monitoring and inspecting the construction of the Tenant Improvements, which sum shall be payable from the TI Fund, Such Administrative Rent shall include, without
limitation, all out-of-pocket costs, expenses and fees incurred by or on behalf of Landlord arising from, out of, or in connection with, such monitoring of the
construction of the Tenant Improvements. If the Budget is greater than the Tenant Improvement Allowance, Tenant shall deposit with Landlord the difference, in cash, prior to the commencement of construction of the Tenant Improvements, for
disbursement by Landlord as described in Section 5(d). 
 (b) Tenant Improvement Allowance. Landlord
shall provide to Tenant a “Tenant Improvement Allowance” in the maximum amount of $50.00 per rentable square foot in the Third Expansion Premises, or $429,700 in the aggregate, which is included in the Base Rent set forth in
Section 5(b) of the Fifth Amendment. 

  
 B-3 

 The Tenant Improvement Allowance shall be disbursed in accordance with this Fifth Amendment
Work Letter. Tenant shall have no right to the use or benefit (including any reduction to Base Rent) of any portion of the Tenant Improvement Allowance not required for the design and construction of (i) the Tenant Improvements described in the
TI Construction Drawings approved pursuant to Section 2(d) or (ii) any Changes pursuant to Section 4. Tenant shall have no right to any portion of the Tenant Improvement Allowance that is not
disbursed before the last day of the month that is 12 months after the Third Expansion Premises Commencement Date. 
 (c) Costs Includable
in TI Fund. The TI Fund shall be used solely for the payment of design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the cost of electrical power and other
utilities used in connection with the construction of the Tenant Improvements, the cost of preparing the TI Design Drawings and the TI Construction Drawings, all costs set forth in the Budget, including Landlord’s Administrative Rent, and the
cost of Changes (collectively, “TI Costs”). Notwithstanding anything to the contrary contained herein, the TI Fund shall not be used to purchase any furniture, personal property or other
non-Building system materials or equipment, including, but not limited to, Tenant’s voice or data cabling, non-ducted biological safety cabinets and other
scientific equipment not incorporated into the Tenant Improvements. Notwithstanding anything to the contrary contained herein, Tenant may use a reasonable and customary portion of the Tenant Improvement Allowance, as reasonably approved by Landlord,
toward the cost of purchasing and installing the Building Signs which Tenant is entitled to install pursuant to Section 38 of the Lease. 

(d) Excess TI Costs. Landlord shall have no obligation to bear any portion of the cost of any of the Tenant Improvements except to the
extent of the Tenant Improvement Allowance. If at any time and from time-to-time, the remaining TI Costs under the Budget exceed the remaining unexpended Tenant
Improvement Allowance, Tenant shall deposit with Landlord, as a condition precedent to Landlord’s obligation to fund the Tenant Improvement Allowance, 100% of the then current TI Cost in excess of the remaining Tenant Improvement Allowance
(“Excess TI Costs”). If Tenant fails to deposit, or is late in depositing any Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not
limited to, the right to interest at the Default Rate and the right to assess a late charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. The Tenant Improvement Allowance
and Excess TI Costs is herein referred to as the “TI Fund.” Funds deposited by Tenant shall be the first thereafter disbursed to pay TI Costs. Notwithstanding anything to the contrary set forth in this
Section 5(d), Tenant shall be fully and solely liable for TI Costs and the cost of Minor Variations in excess of the Tenant Improvement Allowance. If upon Substantial Completion of the Tenant Improvements and the payment of
all sums due in connection therewith there remains any undisbursed portion of the TI Fund, Tenant shall be entitled to such undisbursed TI Fund solely to the extent of any Excess TI Costs deposit Tenant has actually made with Landlord. 

(e) Payment for TI Costs. During the course of design and construction of the Tenant Improvements, Landlord shall reimburse Tenant for
TI Costs once a month against a draw request in Landlord’s standard form, containing evidence of payment of such TI Costs by Tenant and such certifications, lien waivers (including a conditional lien release for each progress payment and
unconditional lien releases for the prior month’s progress payments), inspection reports and other matters as Landlord reasonably and customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days
following receipt of such draw request. Upon completion of the Tenant Improvements (and prior to any final disbursement of the TI Fund), Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and first
tier subcontractors who did the work and final, unconditional lien waivers from all such contractors and first tier subcontractors; (ii) as-built plans (one copy in print format and two copies in
electronic CAD format) for such Tenant Improvements; (iii) a certification of substantial completion in Form MA G704, (iv) a certificate or temporary of occupancy for the Premises (or an equivalent approval); and (v) copies of all
operation and maintenance manuals and warranties affecting the Premises. 

  
 B-4 

 6. Miscellaneous. 

(a) Consents. Whenever consent or approval of either party is required under this Fifth Amendment Work Letter, that party shall
not unreasonably withhold, condition or delay such consent or approval, except as may be expressly set forth herein to the contrary. 
 (b)
Modification. No modification, waiver or amendment of this Fifth Amendment Work Letter or of any of its conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

(c) No Default Funding. In no event shall Landlord have any obligation to fund any portion of the Tenant Improvement Allowance
during any period that Tenant is in Default under the Lease. 

  
 B-5

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