Document:

<PAGE>

                                                                  Exhibit 10.20

                           LOAN MODIFICATION AGREEMENT

     This Loan Modification Agreement (this "Loan Modification Agreement') is
entered into as of December 30, 2002, by and between SILICON VALLEY BANK, a
California-chartered bank, with its principal place of business at 3003 Tasman
Drive, Santa Clara, California 95054 and with a loan production office located
at One Newton Executive Park, Suite 200, 2221 Washington Street, Newton,
Massachusetts 02462, doing business under the name "Silicon Valley East"
("Bank") and SPEECHWORKS INTERNATIONAL, INC., a Delaware corporation with its
chief executive office located at 695 Atlantic Avenue, Boston, Massachusetts
02111 ("Borrower").

1.  DESCRIPTION OF EXISTING INDEBTEDNESS AND OBLIGATIONS. Among other
indebtedness and obligations which may be owing by Borrower to Bank, Borrower is
indebted to Bank pursuant to a loan arrangement dated as of December 28, 2001,
evidenced by, among other documents, a certain Amended and Restated Loan and
Security Agreement dated as of December 28, 2001 between Borrower and Bank (as
may be amended from time to time, the "Loan Agreement"), which amended and
restated a certain Loan and Security Agreement between Borrower and Bank dated
as of March 26, 1999. The Loan Agreement established: (i) an equipment line of
credit in favor of the Borrower in the maximum principal amount of Six Million
Dollars ($6,000,000.00) (the "Committed Equipment Line"), and (ii) a revolving
line of credit in favor of Borrower in the maximum principal amount of Five
Million Dollars ($5,000,000.00) (the "Committed Revolving Line"). Capitalized
terms used but not otherwise defined herein shall have the same meaning as in
the Loan Agreement.

Hereinafter, all indebtedness and obligations owing by Borrower to Bank shall be
referred to as the "Obligations".

2.  DESCRIPTION OF COLLATERAL.  Repayment of the Obligations is secured by the
Collateral as described in the Loan Agreement (together with any other
collateral security granted to Bank, the "Security Documents").

Hereinafter, the Security Documents, together with all other documents
evidencing or securing the Obligations shall be referred to as the "Existing
Loan Documents".

3.   DESCRIPTION OF CHANGE IN TERMS.

     A.   Modifications to Loan Agreement.

          1.   Notwithstanding anything in the Loan Agreement or this Loan
               Modification Agreement to the contrary, no more than Seven
               Hundred Fifty Thousand Dollars ($750,000.00) in Equipment
               Advances under the Committed Equipment Line shall be made to
               Borrower after December 31, 2002.

          2.   The Loan Agreement is hereby amended by deleting the following
               text appearing as the first sentence in Section 2.1.5(a):

                    "Subject to the terms and conditions of this Agreement, Bank
                    agrees to lend to Borrower, from time to time prior to
                    December 31, 2002, equipment advances (each an "Equipment
                    Advance" and collectively the "Equipment Advances") in an
                    aggregate amount not to exceed the Committed Equipment
                    Line."

               and inserting in lieu thereof, the following:

                    "Subject to the terms and conditions of this Agreement, Bank
                    agrees to lend to Borrower, from time to time prior to June
                    30, 2003, equipment advances (each an "Equipment Advance"
                    and collectively the "Equipment Advances") in an aggregate
                    amount not to exceed the Committed Equipment Line."

          3.   The Loan Agreement is hereby amended by deleting the following
               text appearing as Section 6.7 entitled "Financial Covenant":

                    "6.7  Financial Covenant. Borrower shall maintain at all
                    times, to be tested as of the last day of each month:

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                         (a)  Tangible Net Worth. A Tangible Net Worth of at
                         least Fifty Five Million Dollars ($55,000,000.00)."

               and inserting in lieu thereof the following:

                    "6.7 Financial Covenant. Borrower shall maintain at all
                    times, to be tested as of the last day of each month:

                         (a)  Tangible Net Worth. A Tangible Net Worth of at
                         least: (i) $45,000,000.00 through December 31, 2002;
                         (ii) $40,000,000.00 from January 1, 2003 through
                         March 31, 2003; (iii) $35,000,000.00 from April 1, 2003
                         through June 30, 2003; and (iv) $30,000,000.00 from
                         July 1, 2003 and at all  times thereafter."

          4.   In connection with the Bank's rights pursuant to Section 6.2(d)
               of the Loan Agreement, the Borrower shall permit the Bank to
               audit the Borrower's Collateral, at Borrower's expense, on or
               before March 31, 2003.

          5.   Effective as of December 17, 2002, the Loan Agreement is hereby
               amended by deleting the following text appearing in Section 13.1
               thereof entitled "Definitions":

                    ""Prime Rate" is Bank's most recently announced "prime
                    rate," even if it is not Bank's lowest rate."

               and inserting in lieu thereof the following:

                    ""Prime Rate" is Bank's most recently announced "prime
                    rate," even if it is not Bank's lowest rate, except that at
                    no time under this Agreement shall the Prime Rate be less
                    than four and one-quarter percent (4.25%)."

          6.   The Loan Agreement is hereby amended by deleting the following
               text appearing in Section 13.1 thereof entitled "Definitions":

                    ""Revolving Maturity Date" is November 30, 2002."

               and inserting in lieu thereof the following:

                    ""Revolving Maturity Date" is November 29, 2003."

4.  FEES.  Borrower shall pay to Bank: (i) a modification fee for the Committed
Revolving Line (the "Revolving Line Fee") in an amount equal to $12,500.00,
which Revolving Line Fee shall be due and payable on the date hereof and shall
be deemed fully and earned as of the date hereof, and (ii) a modification fee
for the Committed Equipment Line (the "Equipment Line Fee") in an amount equal
to $3,750.00, which Equipment Line Fee shall be deemed fully earned as of the
date hereof and due and payable on June 30, 2003, except that the Equipment Line
Fee shall be waived by Bank in the event that aggregate Equipment Advances of at
least Five Hundred Thousand Dollars ($500,000.00) are made to Borrower on or
after January 1, 2003. The Borrower shall also reimburse Bank for all legal fees
and expenses incurred in connection with this amendment to the Existing Loan
Documents.

5.  RATIFICATION OF NEGATIVE PLEDGE AGREEMENT.  Borrower hereby ratifies,
confirms and reaffirms, all and singular, the terms and conditions of a certain
Negative Pledge Agreement dated as of March 26, 1999 between Borrower and Bank,
and acknowledges, confirms and agrees that said Negative Pledge Agreement shall
remain in full force and effect.

6.  ADDITIONAL COVENANTS.  Borrower shall not, without providing the Bank with
thirty (30) days prior

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written notice: (i) relocate its principal executive office or add any new
offices or business locations or keep any Collateral in any additional
locations, or (ii) change its jurisdiction of organization, or (iii) change its
organizational structure or type, (iv) change its legal name, or (v) change any
organizational number (if any) assigned by its jurisdiction of organization. In
addition, the Borrower hereby certifies that no Collateral is in the possession
of any third party bailee (such as at a warehouse). In the event that Borrower,
after the date hereof, intends to store or otherwise deliver the Collateral to
such a bailee, then Borrower shall first receive, the prior written consent of
Bank and such bailee must acknowledge in writing that the bailee is holding such
Collateral for the benefit of Bank. Borrower hereby ratifies, confirms and
reaffirms, all and singular, the terms and disclosures contained in a certain
Perfection Certificate dated as of December 28, 2001 between Borrower and Bank,
and acknowledges, confirms and agrees the disclosures and information above
Borrower provided to Bank in the Perfection Certificate has not changed, as of
the date hereof.

7.  AUTHORIZATION TO FILE.  Borrower hereby authorizes Bank to file financing
statements without notice to Borrower, with all appropriate jurisdictions, as
Bank deems appropriate, in order to further perfect or protect Bank's interest
in the Collateral.

8.  CONSISTENT CHANGES.  The Existing Loan Documents are hereby amended wherever
necessary to reflect the changes described above.

9.  RATIFICATION OF LOAN DOCUMENTS.  Borrower hereby ratifies, confirms, and
reaffirms all terms and conditions of all security or other collateral granted
to the Bank, and confirms that the indebtedness secured thereby includes,
without limitation, the Obligations.

10.  NO DEFENSES OF BORROWER.  Borrower agrees that, as of this date, it has no
defenses against the obligations to pay any amounts under the Obligations.

11. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the
existing Obligations, Bank is relying upon Borrower's representations,
warranties, and agreements, as set forth in the Existing Loan Documents. Except
as expressly modified pursuant to this Loan Modification Agreement, the terms of
the Existing Loan Documents remain unchanged and in full force and effect.
Bank's agreement to modifications to the existing Obligations pursuant to this
Loan Modification Agreement in no way shall obligate Bank to make any future
modifications to the Obligations. Nothing in this Loan Modification Agreement
shall constitute a satisfaction of the Obligations. It is the intention of Bank
and Borrower to retain as liable parties all makers of Existing Loan Documents,
unless the party is expressly released by Bank in writing. No maker will be
released by virtue of this Loan Modification Agreement.

12. RIGHT OF SET-OFF. In consideration of Bank's agreement to enter into this
Loan Modification Agreement, Borrower and any guarantor hereby reaffirm and
hereby grant to Bank, a lien, security interest and right of setoff as security
for all Obligations to Bank, whether now existing or hereafter arising upon and
against all deposits, credits, collateral and property, now or hereafter in the
possession, custody, safekeeping or control of Bank or any entity under the
control of Silicon Valley Bank or in transit to any of them. At any time after
the occurrence and during the continuance of an Event of Default, without demand
or notice, Bank may set off the same or any part thereof and apply the same to
any liability or obligation of Borrower and any guarantor even though unmatured
and regardless of the adequacy of any other collateral securing the loan. ANY
AND ALL RIGHTS TO REQUIRE BANK TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT
TO ANY OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS
RIGHT OF SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF THE
BORROWER OR ANY GUARANTOR, ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY
WAIVED.

13. JURISDICTION/VENUE. Borrower accepts for itself and in connection with its
properties, unconditionally, the exclusive jurisdiction of any state or federal
court of competent jurisdiction in the Commonwealth of Massachusetts in any
action, suit, or proceeding of any kind against it which arises out of or by
reason of this Loan Modification Agreement; provided, however, that if for any
reason Bank cannot avail itself of the courts of the Commonwealth of
Massachusetts, then venue shall lie in Santa Clara County, California.
NOTWITHSTANDING THE FOREGOING, THE BANK SHALL HAVE THE RIGHT TO BRING ANY ACTION
OR PROCEEDING AGAINST THE BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER
JURISDICTION WHICH THE BANK DEEMS NECESSARY OR APPROPRIATE IN ORDER TO REALIZE
ON THE COLLATERAL OR TO

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OTHERWISE ENFORCE THE BANK'S RIGHTS AGAINST THE BORROWER OR ITS PROPERTY.

14.  COUNTERSIGNATURE.  This Loan Modification Agreement shall become effective
only when it shall have been executed by Borrower and Bank (provided, however,
in no event shall this Loan Modification Agreement become effective until signed
by an officer of Bank in California).

     This Loan Modification Agreement is executed as a sealed instrument under
the laws of the Commonwealth of Massachusetts as of the date first written
above.

BORROWER:                                 BANK:

SPEECHWORKS INTERNATIONAL, INC.           SILICON VALLEY BANK, doing business as
                                          SILICON VALLEY EAST

By:    Richard Westelman                  By:     Michael Tramack
       -------------------------------            ------------------------------

Name:  Richard Westelman                  Name:   Michael Tramack
       -------------------------------            ------------------------------

Title: Chief Financial Officer            Title:  Vice President
       -------------------------------            ------------------------------

                                          SILICON VALLEY BANK

                                          By:     Michelle Giannini
                                                  ------------------------------

                                          Name:   Michelle Giannini
                                                  ------------------------------

                                          Title:  AVP
                                                  ------------------------------
                                                  (signed in Santa Clara County,
                                                  California)MEMORANDUM OF LEASE AGREEMENTS

 
EXHIBIT 10.1

 
THIRD AMENDMENT TO LEASE AGREEMENT

 
THIS THIRD AMENDMENT TO LEASE AGREEMENT
(hereinafter referred to as the “Third Amendment”) is made as of the 1st day of January, 2001 by and
between FUSCO HARBOUR ASSOCIATES, LLC, a Connecticut limited liability company, with offices and a principal place of business c/o The Fusco Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511 (said Fusco Harbour Associates, LLC, its
successors and assigns hereinafter referred to as the “Landlord”) and CURAGEN CORPORATION, a Delaware corporation with an office at 555 Long Wharf Drive, New Haven, Connecticut 06511 (said CuraGen Corporation, its successors and assigns
hereinafter referred to as the “Tenant”). 
 
WITNESSETH: That 
 
WHEREAS, Landlord and Tenant entered into that certain Lease Agreement dated December 23, 1996 (the “Lease”) whereunder Landlord leased to Tenant and Tenant leased from Landlord twenty six thousand two hundred sixty six
(26,266) rentable square feet of floor area located on the eleventh floor of Landlord’s Building as described in said Lease; and 
 
WHEREAS, Landlord and Tenant entered into that certain First Amendment to Lease Agreement dated as of the 27th day of October, 1997 (the “First Amendment”) whereunder Landlord leased to Tenant and Tenant leased from Landlord an
additional five thousand three hundred ninety seven (5,397) rentable square feet of floor area located on the thirteenth floor of Landlord’s Building (the “First Expansion Premises”), on terms and conditions as described in said First
Amendment; and 
 
WHEREAS, Landlord and Tenant
entered into that certain Second Amendment to Lease Agreement dated as of the 31st day of August, 1998 (the
“Second Amendment”) whereunder Landlord leased to Tenant and Tenant leased from Landlord (i) an additional two thousand nine hundred twenty eight (2,928) rentable square feet of floor area on the thirteenth floor of Landlord’s
Building (the “Second Expansion Premises”) and (ii) an additional one thousand three hundred forty seven (1,347) rentable square feet of floor area situated on the thirteen floor of Landlord’s Building (the “Third Expansion
Premises”); and 
 
WHEREAS, Landlord and
Tenant desire that Tenant shall lease additional space on the ninth floor of Landlord’s Building which additional space shall be let, to Tenant upon the terms and conditions contained hereinafter; and 
 
WHEREAS, the parties desire to enter into this Third Amendment
to set forth the terms and conditions of their agreement in connection with the foregoing; 
 
NOW THEREFORE, in consideration of the mutual terms, conditions and covenants as contained in said Lease, as contained in said First Amendment, as contained in said Second Amendment, and as contained
in the herein Third Amendment, the parties hereto do hereby agree as follows: 
 
1. Article 1. Premises, is hereby amended by the addition thereto of a new paragraph A-3. to be inserted after paragraph A-2. now there appearing, which paragraph A-3. shall stipulate as
follows: 
 
“A-3. In addition
to the foregoing, effective January 1,2001, Landlord does hereby lease to Tenant and Tenant does hereby lease from Landlord an additional four thousand five hundred twenty four (4,524) rentable square feet of floor area situated on the ninth floor
of Landlord’s Building in the area designated on Exhibit B-3 annexed hereto and made a part hereof (the “Fourth Expansion Premises”). 

 
Whenever the defined term “Premises” shall be used hereinafter it shall, wherever the context may indicate or wherever proper reading may require, also be deemed to refer to the First Expansion Premises, the Second
Expansion Premises, the Third Expansion Premises and the Fourth Expansion Premises in all respects as if initially the said First Expansion Premises, Second Expansion Premises, Third Expansion Premises and Fourth Expansion Premises were fully
includable within the intent of the defined term “Premises”.” 
 
2. Article 3. Term, is hereby amended by the addition thereto of a new paragraph A- 4. to be inserted after paragraph A-2. now there appearing, which new paragraph A-4. shall stipulate the
following: 
 
“A-4. TO HAVE
AND HOLD the Fourth Expansion Premises for a period and term commencing January 1,2001 and ending at midnight December 31, 2002 (the “Fourth Expansion Premises Initial Term”). 
 
3. Article 3. Term is hereby further amended by the addition thereto of a new paragraph C-3. to be
inserted after paragraph C-3. now there appearing which new paragraph C- 3. shall stipulate the following: 
 
“C-3. Notwithstanding anything contained in the herein Lease to the contrary, or any amendment thereto, the Initial
Term with respect to all portions of the Premises (including the Initial Premises, the First Expansion Premises, the Second Expansion Premises, the Third Expansion Premises and the Fourth Expansion Premises) shall each and all extend to and end at
midnight December 31, 2002. The parties recognize that rights granted to Tenant pursuant to paragraph 3.C. of said Lease with respect to options to renew the herein Lease shall remain operative in all respects and shall apply to all portions of the
Premises.” 
 

2 

 
4. Article 4.
Rent and Rent Commencement, is hereby amended by the deletion in its entirety of paragraph A. set forth therein and by the substitution in its place and stead of the following paragraph A.: 
 
A. Tenant covenants and agrees to pay to
Landlord and Landlord shall be entitled to receive during the Initial Term of this Lease Agreement, an annual base rental (“Base Rent”) in the following amounts: 
 

	 Fiscal Period
 of Lease

	    	 Base Rent Per Square Foot

	  	 Annualized Base Rent

	  	 Monthly Installments

	 1. Year One:
	    	 	 	  	 	 	  	 	 
	 a) January 1, 1997 to July 1, 1997
	    	 $
	 0
	  	 $
	 0
	  	 $
	 0

	 b) July 1, 1997 to December 1, 1997
	    	 $
	 10.00
	  	 $
	 262,660.00
	  	 $
	 21,888.33

	 c) December 1, 1997 to January 1, 1998
	    	 $
	 10.00
	  	 $
	 316,630.00
	  	 $
	 26,385.83

	 2. Year Two:
	    	 	 	  	 	 	  	 	 
	 a) January 1, 1998 to April 1, 1998
	    	 $
	 10.00
	  	 $
	 316,630.00
	  	 $
	 26,385.83

	 b) April 1, 1998 to October 1, 1998
	    	 $
	 20.50
	  	 $
	 649,091.50
	  	 $
	 54,090.96

	 c) October 1, 1998 to November 1, 1998*
	    	 $
	 20.50
	  	 $
	 709,115.50
	  	 $
	 59,092.96

	 d) November 1, 1998* to January 1, 1999
	    	 $
	 20.50
	  	  
	 736,729.00
	  	 $
	 61,394.08

	 	

*Or earlier date if Third Expansion Premises are
made available to Tenant on earlier date per paragraph 1. hereinabove. 
 

3 

 

	 Fiscal Period
 of Lease

	    	 Base Rent Per Square Foot

	 	    	 Annualized Base Rent

	  	 Monthly Installments

	 3. Years Three and Four:
	    	 	 	 	    	 	 	  	 	 
	 January 1, 1999 through December 31, 2000
	    	 $
	 20.50
	  
	    	 $
	 736,729.00
	  	 $
	 61,394.08

	 Year Five:
	    	 	 	 	    	 	 	  	 	 
	 January 1, 2001 through December 31, 2001
	    	 $
 $
	 20.50
 22.50
	 *
 **
	    	 $
	 838,519.00
	  	 $
	 69,876.58

	 Year Six:
	    	 	 	 	    	 	 	  	 	 
	 January 1, 2002 to December 31, 2002
	    	 $
 $
	 21.50
 22.50
	 *
 **
	    	 $
	 874,457.00
	  	 $
	 72,871.42

	 	

	 	*	 	With respect to 35,938 square feet (Original, First, Second and Third Expansion Premises) 

	 	**	 	With respect to 4,524 square feet (Fourth Expansion Premises)” 

 
5. Article 14. Construction, is hereby amended by the addition thereto of a new paragraph G. to appear after
paragraph F. which paragraph G. shall stipulate as follows: 
 
“G. Notwithstanding the foregoing or anything contained herein to the contrary, the Fourth Expansion Premises shall be delivered to Tenant prior to commencement of the Fourth Expansion Premises Initial Term on an “as
is” basis, and any improvements to the Fourth Expansion Premises shall be the sole responsibility of and at cost of Tenant. If Tenant shall elect to make such improvements, Tenant shall comply in all respects with paragraph 6.D. of the Lease
set forth hereinabove.” 
 
6. Article 36.
Brokerage, is hereby amended by the addition thereto of a new paragraph which paragraph shall stipulate the following: 
 
“Further notwithstanding the foregoing, Landlord and Tenant covenant and agree to and with each other that no broker
is recognized as being responsible for consummation of the herein Third Amendment or the leasing from Landlord to Tenant of the Fourth Expansion Premises. Landlord and Tenant mutually agree to indemnify the other and to hold the other harmless from
all suits, claims and demands brought by any party for brokerage commission with respect to leasing of the Fourth Expansion Premises.” 
 
7. Exhibit E, PARKING, NO. OF SPACES, is hereby amended by the deletion of reference to one hundred (100) unreserved spaces and by
substitution in its place and stead of reference to one hundred thirteen (113) unreserved spaces, two of which shall be located in the “contractor lot”, so-called, located on the ground floor of the structured parking facility.

 

4 

 
8. Exhibit E,
PARKING, COST PER PARKING SPACE, is hereby amended by the deletion of reference to one hundred (100) unreserved spaces and by substitution in its place and stead of reference to one hundred thirteen (113) unreserved spaces. Reference to eighty three
(83) Additional Spaces at costs stipulated therein shall remain without amendment. 
 
9. Ratification. The terms, conditions and provisions of said Lease Agreement as amended by the terms, conditions and provisions of the First Amendment and the Second Amendment are hereby
ratified and confirmed in all respects except as amended by the terms, conditions and provisions of the herein Third Amendment. 
 
19. Conflict. In the event of any conflict between the terms, conditions and provisions of this Third Amendment and the terms,
conditions and provisions of said Lease Agreement, as amended by the said First Amendment and the said Second Amendment, then in such event the terms, conditions and provisions of this Third Amendment shall govern and prevail in all respects.

 
IN WITNESS WHEREOF, the parties hereto have set
their hands and seals as of the day and year first above written. 
 
In the presence of: 
LANDLORD 
 
FUSCO HARBOUR ASSOCIATES, LLC 
 
By:
                                        
                                        
                     
 
Edmund J. Fusco 
 
Its Manager 
 
Duly Authorized 
 
 

5 

 

	 In the presence of:
	 	 TENANT
 CURAGEN CORPORATION

	
 Elizabeth A. Whayland
	 	
 David M. Wurzer

	
 Catherine Mugo
	 	 Its EVP & CFO
 Duly Authorized

 
 
 
STATE OF CONNECTICUT) ) 
ss.: New Haven; December 21, 2000 
COUNTY OF NEW HAVEN) 
 
Personally
appeared, Edmund J. Fusco, Jr., Manager of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be his free act and deed and the free act and deed of said corporation, before me.  ̈ 
 
                                     
                                        
                                        
                           
Notary Public 
My Commission Expires March 31, 2001 
 
STATE OF CONNECTICUT) ) 
ss.: New Haven; 
COUNTY OF NEW HAVEN) 
 
Personally appeared, David M. Wurzer, EVP & CFO, of CURAGEN CORPORATION, signer and sealer of the foregoing instrument, and
acknowledged the same to be his free act and deed and the free act and deed of said corporation, before me. 
 
Terrie B. Atkinson                                
                                        
                 
Notary Public 
My Commission Expires November 30, 2004 
 

6 

 
FOURTH
AMENDMENT TO 
LEASE AGREEMENT 
 
FUSCO HARBOUR ASSOCIATES, LLC 
LANDLORD 
 
AND 
 
CURAGEN CORPORATION 
TENANT 
 
LONG WHARF MARITIME CENTER 
BUILDING 1 
555 LONG WHARF DRIVE 
NEW HAVEN, CONNECTICUT 
 
DATE:
AS OF 
 
June 5, 2001 

 
FOURTH
AMENDMENT TO LEASE AGREEMENT 
 
THIS FOURTH
AMENDMENT TO LEASE AGREE~T (hereinafter referred to as the “Fourth Amendment”) is made as of the 5th day
of June, 2001 by and between FUSCO HARBOUR ASSOCIATES, LLC, a Connecticut limited liability company, with offices and a principal place of business c/o The Fusco Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511 (said Fusco Harbour
Associates, LLC, its successors and assigns hereinafter referred to as the “Landlord”) and CURAGEN CORPORATION, a Delaware corporation with an office at 555 Long Wharf Drive, New Haven, Connecticut 06511 (said CuraGen Corporation, its
successors and assigns hereinafter referred to as the “Tenant”). 
 
WITNESSETH: That 
 
WHEREAS, Landlord and Tenant entered into that certain Lease Agreement dated December 23, 1996 (the “Lease”) whereunder Landlord leased to Tenant and Tenant leased from Landlord twenty six thousand two hundred sixty six
(26,266) rentable square feet of floor area located on the eleventh floor of Landlord’s Building (the “Initial Premises”) as described in said Lease; and 
 
WHEREAS, Landlord and Tenant entered into that certain First Amendment to Lease Agreernent dated as of the
27th day of October, 1997 (the “First Amendment”) whereunder Landlord leased to Tenant and Tenant leased
from Landlord an additional five thousand three hundred ninety seven (5,397) rentable square feet of floor area located on the thirteenth floor of Landlord’s Building (the “First Expansion Premises”), on terms and conditions as
described in said First Amendment; and 
 
WHEREAS,
Landlord and Tenant entered into that certain Second Amendment to Lease Agreement dated as of the 31 It day of August, 1998 (the “Second Amendment”) whereunder Landlord leased to Tenant and Tenant leased from Landlord (i) an additional two
thousand nine hundred twenty eight (2,928) rentable square feet of floor area on the thirteenth floor of Landlord’s Building (the “Second Expansion Premises”) and (ii) an additional one thousand three hundred forty seven (1,347)
rentable square feet of floor area situated on the thirteen floor of Landlord’s Building (the “Third Expansion Premises”); and 
 
WHEREAS, Landlord and Tenant entered into that certain Third Amendment to Lease Agreement dated as of the 1st day of January, 2001, whereunder Landlord leased to Tenant and Tenant leased from Landlord an additional four thousand five
hundred twenty four (4,524) rentable square feet of floor area located on the ninth floor of Landlord’s Building (the “Fourth Expansion Premises”); and 

 
WHEREAS,
Landlord and Tenant desire that Tenant shall lease additional space on the ninth floor of Landlord’s Building which additional space shall be let to Tenant upon the terms and conditions contained hereinafter; and 
 
WHEREAS, the parties desire to enter into this Fourth
Amendment to set forth the terms and conditions of their agreement in connection with the foregoing; 
 
NOW THEREFORE, in consideration of the mutual terms, conditions and covenants as contained in said Lease, as contained in said First
Amendment, as contained in said Second Amendment, as contained in the Third Amendment, and as contained in the herein Fourth Amendment, the parties hereto do hereby agree as follows: 
 
1. Article 1. Premises is hereby amended by the addition thereto of a new paragraph A-4. to be
inserted after paragraph A-3. now there appearing, which paragraph A-4. shall stipulate as follows: 
 
“A-3. In addition to the foregoing, effective July 1,2001, Landlord does hereby lease to Tenant and Tenant does
hereby lease from Landlord an additional seven thousand two hundred ninety (7,290) rentable square feet of floor area situated on the ninth floor of Landlord’s Building in the area designated on Exhibit B-4 annexed hereto and made a part hereof
(the “Fifth Expansion Premises”). The total rentable area leased to Tenant on the said ninth floor shall as of such date be eleven thousand eight hundred fourteen (11,814) rentable square feet. 
 
Whenever the defined term
“Premises” shall be used hereinafter it shall, wherever the context may indicate or wherever proper reading may require, also be deemed to refer to the First Expansion Premises, the Second Expansion Premises, the Third Expansion Premises,
the Fourth Expansion Premises and the Fifth Expansion Premises in all respects as if initially the said First Expansion Premises, Second Expansion Premises, Third Expansion Premises, Fourth Expansion Premises and Fifth Expansion Premises were fully
includable within the intent of the defined term “Premises”, all until January 1, 2003, at which time the term “Premises” shall be deemed thereupon and thereafter to refer solely to the Fourth Expansion Premises and the Fifth
Expansion Premises respectively.” 
 
2.
Article 3. Term, is hereby amended by the addition thereto of a new paragraph A- 5. to be inserted after paragraph A-4. now there appearing, which new paragraph A-5. shall stipulate the following: 
 
“A-5. TO HAVE AND HOLD the Fifth
Expansion Premises for a period and term commencing July 1,2001 (the “Fifth Expansion Premises Commencement Date”).” 
 

2 

 
3. Article 3.
Term, is hereby further amended by the addition thereto of a new paragraph C-4. to be inserted after paragraph C-3. now there appearing which new paragraph C- 4. shall stipulate the following: 
 
“C-4. Effective as of the date of the
herein Fourth Amendment and notwithstanding anything contained in the Lease, as amended, to the contrary, the term of this Lease, as amended, with respect to all portions of the Initial Premises, the First Expansion Premises, the Second Expansion
Premises and the Third Expansion Premises (being all portions of the Premises located on the eleventh floor and thirteenth floor of Landlord’s Building) shall each and all extend to and end at midnight December 31, 2002. The term of this Lease,
as amended, with respect to all portions of the Fourth Expansion Premises and the Fifth Expansion Premises (being all portions of the Premises located on the ninth floor of Landlord’s Building) shall each extend to and end at midnight on June
30, 2006. The parties acknowledge, recognize and agree that any rights of first refusal, rights to expand and rights to renew or extend the teml hereof as stipulated or provided for in said Lease, as amended, wherever appearing and however stated,
shall not apply in any manner to the Fourth Expansion Premises or Fifth Expansion Premises, any such rights of first refusal, renewal, extension or expansion existing pursuant to the temlS of the Lease, as amended, wherever appearing or however
stipulated, being expressly deemed to be inapplicable with respect to said Fourth or Fifth Expansion Premises.” 
 
4. Article 4. Rent and Rent Commencement is hereby amended by the addition thereto of a new paragraph A-I. to be inserted after
paragraph A. now there appearing, which paragraph A-I. shall stipulate the following: 
 
“A-I. Notwithstanding anything contained in the foregoing paragraph A. to the contrary, Tenant covenants and agrees
to pay to Landlord and Landlord shall be entitled to receive an annual base rental (“Base Rent”) during the following periods of time in the following amounts: 
 

	 Fiscal Period
 of Lease

	    	 Base Rent Per Square Foot

	 	    	 Annualized Base Rent

	  	 Monthly Installments

	 1. Year Five:
	    	 	 	 	    	 	 	  	 	 
	 a) January 1,2001 to July 1, 2001
	    	 $
 $
	 20.50
 22.50
	 *
 **
	    	 $
	 838,519.00
	  	 $
	 69,876.58

	 b) July 1, 2001 through December 31, 2001
	    	 $
 $
 $
	 20.50
 22.50
 25.00
	 *
 **

***
	    	 $
	 1,020,769.00
	  	 $
	 85,064.08

 

3 

	 Fiscal Period
 of Lease

	    	 Base Rent Per Square Foot

	 	    	 Annualized Base Rent

	  	 Monthly Installments

	 2. Year Six:
	    	 	 	 	    	 	 	  	 	 
	 January 1, 2002 through December 31, 2002
	    	 $
 $
 $
	 21.50
 22.50
 25.00
	 *
 **
 ***
	    	 $
	 1,056,707.00
	  	 $
	 88,058.92

	 3. Years Seven through Ten:
	    	 	 	 	    	 	 	  	 	 
	 January 1, 2003 through June 30, 2006
	    	 $
	 25.00
	 ****
	    	 $
	 295,350.00
	  	 $
	 24,612.50

	 	

	 	*	 	With respect to 35,938 square feet (Initial, First, Second and Third Expansion Premises) 

	 	**	 	With respect to 4,524 square feet (Fourth Expansion Premises) 

	 	***	 	With respect to 7,290 square feet (Fifth Expansion Premises) 

	 	****	 	With respect to the total ninth floor premises (Fourth and Fifth Expansion Premises) of 11,814 square feet 

 
All such Base Rent shall be paid on a monthly installment
basis, in advance, on the first day of each month during the term hereof.” 
 
5. Article 14. Construction, is hereby amended by the addition thereto of a new paragraph H. to appear after paragraph G. which paragraph H. shall stipulate the following: 
 
“H. Notwithstanding the foregoing or
anything contained herein to the contrary, the Fifth Expansion Premises shall be delivered to Tenant prior to commencement of the Fifth Expansion Premises Commencement Date on an “as is” basis. Any improvements to the Fifth Expansion
Premises shall be the sole responsibility of and at the cost of Tenant. If Tenant shall elect to make such improvements, Tenant shall comply in all respects with paragraph 6.0. of the Lease set forth hereinabove. Tenant shall be entitled to early
possession of the Premises for such purposes upon the date of execution of this Fourth Amendment.” 
 
6. Article 31. Assignment, is hereby amended by the addition thereto of a new paragraph D. which paragraph D. shall stipulate the
following: 
 
“D.
Notwithstanding anything contained hereinabove in paragraphs A., B. or C., the parties agree that effective as of the date of the herein Fourth Amendment, any 
 

4 

 
intent, attempt or effort on
the part of Tenant to either assign this Lease, as amended, with respect to the Fourth Expansion Premises and Fifth Expansion Premises (collectively in this paragraph the “Ninth Floor Premises”), or to sublet any portion of the Ninth Floor
Premises, shall first give rise to a right of call on the part of Landlord either (a) to take back the entirety of the Ninth Floor Premises in the event of an intended assignment of this Lease or a sublease of the entirety of the Ninth Floor
Premises, or (b) to take back such lesser portion of the Ninth Floor Premises as Tenant shall intend to sublease. In either event the herein Lease shall be terminated as to the portion taken back by Landlord in accordance with the provisions
contained hereinafter in this paragraph, but shall remain in full force and effect as to any portion remaining and not taken back. In the alternative, however, Landlord shall have the right at Landlord’s election either (i) to permit any
assignment or sublease of the said Premises or any portion thereof requested on the part of Tenant to be consummated without taking back any such portion of the said Premises; or (ii) to withhold consent to any such assignment or sublease without
taking back any portion of the said Premises, all in accordance with the provisions contained hereinafter in this paragraph. 
 
The provisions of this paragraph D. shall operate in such manner that if Tenant shall intend to assign this Lease, as amended, in
connection with the Ninth Floor Premises or to sublet all or any portion thereof, Tenant shall notify Landlord in writing of such intent in sufficient detail so as to apprise Landlord of the business and other terms and conditions of any such
intended assignment or sublease. Landlord shall thereafter have fifteen (15) business days in which to notify Tenant in writing of its election as to whether (a) Landlord shall exercise its call rights and take back the said Premises or such portion
thereof as intended by Tenant to be subleased; or (b) whether Landlord shall waive such call rights and permit any such assignment or sublease of the said Premises or any portion thereof to be consummated by Tenant; or (c) whether Landlord shall
withhold its consent to any such assignment or sublease. 
 
In the event that Landlord shall exercise its call rights, the herein Lease with respect to the Ninth Floor Premises or such lesser portion thereof as to which Landlord’s call rights shall appertain, shall terminate as of a date
certain to be identified by Landlord in the above referenced notice to Tenant In the event of permitted assignment or sublease, Tenant shall be entitled to consummate such assignment or sublease transaction on the terms outlined in Tenant’s
notice of request to Landlord. Any Base Rent and/or Additional Rent or any other manner of consideration paid by any assignee or sublessee in excess of the value of that being paid by Tenant hereunder shall be tendered to Landlord periodically from
time to time within ten (10) days of receipt by Tenant thereof. In the event that Landlord shall withhold its consent to any such assignment or sublease, then in such event this Lease and Tenant’s obligations hereunder shall remain in full
force and effect Landlord agrees that any request by Tenant for the consent of Landlord to any such assignment or sublease shall not be unreasonably withheld, delayed or conditioned. 
 

5 

The provisions of the herein paragraph D. shall supersede and take priority over the
provisions of paragraph A., B. and C. hereinabove.” 
 
7. Article 36. Brokerage, is hereby amended by the addition thereto of a new paragraph which paragraph shall stipulate the following: 
 
“Further notwithstanding the foregoing, Landlord and Tenant covenant and agree to and with each other that no broker
is recognized as being responsible for consummation of the herein Fourth Amendment or the leasing from Landlord to Tenant of the Fifth Expansion Premises. Landlord and Tenant mutually agree to indemnify the other and to hold the other harmless from
all suits, claims and demands brought by any party for brokerage commission with respect to leasing of the Fifth Expansion Premises.” 
 
8. Exhibit E, PARKING, NO. OF SPACES, is hereby amended by the deletion of reference to one hundred thirteen (113) unreserved spaces and
by substitution in its place and stead of reference to one hundred thirty three (133) unreserved spaces (two of which shall be located in the “contractor lot”, so-called, located on the ground floor of the structured parking facility)
until January 1, 2003 at which time the number of spaces shall be reduced to a total of thirty three (33) spaces included in the Base Rent being paid by Tenant. Additional spaces may be leased from time to time at then prevailing market rental
rates, plus applicable sales taxes, and strictly subject to availability. Reference to eighty three (83) Additional spaces at costs stipulated therein shall remain without amendment until January 1, 2003 at which time such reference shall expire and
such right to lease such Additional spaces shall expire by the express provision hereof. 
 
9. Ratification. The terms, conditions and provisions of said Lease Agreement as amended by the terms, conditions and provisions of the First Amendment, the Second Amendment and the Third
Amendment are hereby ratified and confirmed in all respects except as amended by the terms, conditions and provisions of the herein Fourth Amendment. 
 
10. Conflict. In the event of any conflict between the tenns, conditions and provisions of this Fourth Amendment and the tenns,
conditions and provisions of said Lease Agreement, as amended by the said First Amendment, the said Second Amendment and the said Third Amendment, then in such event the tenns, conditions and provisions of this Fourth Amendment shall govern and
prevail in all respects. 
 

6 

 
IN WITNESS
WHEREOF, the parties hereto have set their hands and seals as of the day and year first above written. 
 

	 In the presence of:
	 	 In the presence of:
 LANDLORD
 FUSCO HARBOUR ASSOCIATES, LLC

	
	 	 	 By:    Lynn Fusco Hughes

 Duly Authorized

	
	 	 	 By:    Edmund J. Fusco, Jr.

 Duly Authorized

 

	 In the presence of:
	 	 TENANT
 CURAGEN CORPORATION

	
	 	 	 By:    David M. Wurzer

 Its EVP & CFO
 Duly
Authorized

 

7 

 
STATE OF CONNECTICUT)

) ss.: New Haven; June 13, 2001 
COUNTY OF NEW HAVEN) 
 
Personally appeared, Lynn Fusco Hughes, _____________________________________ of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be her free act and deed and the free act and
deed of said company, before me. 
 
STATE OF CONNECTICUT)

) ss.: New Haven; June 13, 2001 
COUNTY OF NEW HAVEN) 
 
Personally appeared, Edmund J. Fusco, Jr., _____________________________________ of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be his free act and deed and the free act
and deed of said company, before me. 
 
STATE OF CONNECTICUT)

) ss.: New Haven; 
COUNTY OF NEW HAVEN) 
 
Personally
appeared, _____________________________________ , of CURAGEN CORPORATION, signer and sealer of the foregoing instrument, and acknowledged the same to be his/her free act and deed and the free act and deed of said corporation, before me.

 
Wendy F. Bristow                                
                                        
     
Notary Public 
My Commission Expires: 3/31/06 
 

8 

 
FIFTH AMENDMENT
TO 
LEASE AGREEMENT 
 
FUSCO HARBOUR ASSOCIATES, LLC 
LANDLORD 
 
AND 
 
CURAGEN CORPORATION 
TENANT 
 

 
LONG WHARF MARITIME CENTER 
BUILDING l 
555
LONG WHARF DRIVE 
NEW HAVEN, CONNECTICUT 
 

 
DATE: MARCH 12th, 2002 

 
FIFTH
AMENDMENT TO LEASE AGREEMENT 
 
THIS FIFTH
AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Fifth Amendment”) is made as of the 12th day
of March, 2002 by and between FUSCO HARBOUR ASSOCIATES, LLC, a Connecticut limited liability company, with offices and a principal place of business c/o The Fusco Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511 (said Fusco Harbour
Associates, LLC, its successors and assigns hereinafter referred to as the “Landlord”) and CURAGEN CORPORATION, a Delaware corporation with an office at 555 Long Wharf Drive, New Haven, Connecticut 06511 (said CuraGen Corporation, its
successors and assigns hereinafter referred to as the “Tenant”). 
 
WITNESSETH: That 
 
WHEREAS, Landlord and Tenant entered into that certain Lease Agreement dated December 23,1996 (the “Lease”) whereunder Landlord leased to Tenant and Tenant leased from Landlord twenty six thousand two hundred sixty six
(26,266) rentable square feet of floor area located on the eleventh floor of Landlord’s Building (the “Initial Premises”) as described in said Lease; and 
 
WHEREAS, Landlord and Tenant entered into that certain First Amendment to Lease Agreement dated as of the
27th day of October, 1997 (the “First Amendment”) whereunder Landlord leased to Tenant and Tenant leased
from Landlord an additional five thousand three hundred ninety seven (5,397) rentable square feet of floor area located on the thirteenth floor of Landlord’s Building (the “First Expansion Premises”), on terms and conditions as
described in said First Amendment; and 
 
WHEREAS,
Landlord and Tenant entered into that certain Second Amendment to Lease Agreement dated as of the 31st day of
August, 1998 (the “Second Amendment”) whereunder Landlord leased to Tenant and Tenant leased from Landlord (i) an additional two thousand nine hundred twenty eight (2,928) rentable square feet of floor area on the thirteenth floor of
Landlord’s Building (the “Second Expansion Premises”) and (ii) an additional one thousand three hundred forty seven (1,347) rentable square feet of floor area situated on the thirteen floor of Landlord’s Building (the “Third
Expansion Premises”); and 
 
WHEREAS, Landlord
and Tenant entered into that certain Third Amendment to Lease Agreement dated as of the 1st day of January, 2001,
whereunder Landlord leased to Tenant and Tenant leased from Landlord an additional four thousand five hundred twenty four (4,524) rentable square feet of floor area located on the ninth floor of Landlord’s Building (the “Fourth Expansion
Premises”); and 

 
WHEREAS,
Landlord and Tenant entered into that certain Fourth Amendment to Lease Agreement dated as of the 5th day of June,
2001, whereunder Landlord leased to Tenant and Tenant leased from Landlord an additional seven thousand two hundred ninety (7,290) rentable square feet of floor area located on the ninth floor of Landlord’s Building (the “Fifth Expansion
Premises”); and 
 
WHEREAS, the parties desire
that the Term hereof with respect to those portions of the Premises as are located on the eleventh and thirteenth floors of Landlord’s Building be extended for a five (5) year period ending at midnight December 31, 2007; and 
 
WHEREAS, the parties desire to enter into this Fifth Amendment
to set forth the terms and conditions of their agreement in connection with the foregoing; 
 
NOW THEREFORE, in consideration of the mutual terms, conditions and covenants as contained in said Lease, as contained in said First Amendment, as contained in said Second Amendment, as contained in
the Third Amendment, as contained in the Fourth Amendment, and as contained in the herein Fifth Amendment, the parties hereto do hereby agree as follows: 
 
1.    Article 3., Term. is hereby amended by the addition thereto of a new paragraph C- 5. to be inserted after
paragraph C-4. now there appearing which new paragraph C-5. shall stipulate the following: 
 
“C-5. Notwithstanding anything contained in the Lease, as amended, to the contrary, the Term of this Lease, as
amended, with respect to all portions of the Initial Premises, the First Expansion Premises, the Second Expansion Premises and the Third Expansion Premises (being all portions of the Premises located on the eleventh floor and thirteenth floor of
Landlord’s Building) shall each and all extend to and end at midnight December 31, 2007. The term of this Lease, as amended, with respect to all portions of the Fourth Expansion Premises and the Fifth Expansion Premises (being all portions of
the Premises located on the ninth floor of Landlord’s Building) shall each continue to extend to and end at midnight on June 30, 2006 as stipulated and set forth in the Fourth Amendment. The parties acknowledge, recognize and agree that any
rights of first refusal, rights to expand and rights to renew or extend the term hereof as stipulated or provided for in said Lease, as amended, wherever appearing and however stated, shall not apply in any manner hereafter. Holding over after the
end of the Term with respect to any portion of the Premises is strictly prohibited.” 
 
2.    Article 4., Rent and Rent Commencement, is hereby amended by the addition thereto of a new paragraph A-2. to be inserted after paragraph A-I. now there appearing, which
paragraph A-2. shall stipulate the following: 
 
“A-2. Notwithstanding anything contained in the foregoing paragraph A-I. to the contrary, commencing January 1, 2003 (prior to which time the rental structure set forth 
 

2 

 
in the Fourth Amendment shall
continue to be applicable), Tenant covenants and agrees to pay to Landlord and Landlord shall be entitled to receive an annual base rental (“Base Rent”) during the following periods of time in the following amounts: 
 

	 Fiscal Period
 of Lease

	 	 Base Rent Per
 Square Foot

	 	 Annualized
 Base Rent

	 	 Monthly
 Installments

	 * 1/1/03 through 6/30/06
	 	 $25.00
	 	 $1,193,800.00
	 	 $99,483.33

	 ** 7/1/06 through 12/31/07
	 	 $25.00
	 	 $898,450.00
	 	 $74,870.83

 

	*	 	With respect to entire leased Premises of 47,752 rentable square feet 

 

	**	 	With respect to the portion of Premises on 11th and 13th floors containing 35,938 rentable square feet 

 
All such Base Rent shall be paid on a monthly installment basis, in advance,
on the first day of each month during the term hereof.” 
 
3.    Article 14., Construction, is hereby amended by the addition thereto of a new to appear after paragraph H. which paragraph I. shall stipulate the following: 
 
“I. Notwithstanding anything contained
herein to the contrary, as of and after the date hereof, the Premises shall continue to be leased on an “as is” basis, and any improvements to the Premises shall be the sole responsibility of and at the cost of Tenant. If Tenant shall
elect to make such improvements, Tenant shall comply in all respects with paragraph 6.D. of the Lease set forth hereinabove.” 
 
4.    Article 31., Assignment, is hereby amended by the addition thereto of a new paragraph E. which paragraph
E. shall stipulate the following: 
 
“E.
Notwithstanding anything contained hereinabove in paragraphs A., B., C. or D., the parties agree that effective as of the date of the herein Fifth Amendment, any intent, attempt or effort on the part of Tenant to either (i) assign this Lease, as
amended, with respect to the Initial Premises, the First Expansion Premises, the Second Expansion Premises or the Third Expansion Premises (being all portions of the Premises located on the eleventh and thirteenth floors of Landlord’s Building
containing a total of thirty five thousand nine hundred thirty eight (35,938) rentable square feet and collectively in this paragraph referred to as the “Upper Floor Premises”), or (ii) to sublet any portion of the Upper Floor Premises,
shall first give rise to a right of call on the part of Landlord (“Call Rights”) either (a) to take back the entirety of the Upper Floor Premises in the event of an intended assignment of this Lease or a sublease of the entirety of the
Upper Floor Premises, or (b) to take back such lesser portion of the Upper Floor Premises as Tenant 
 

3 

 
shall intend to sublease. In
either event the herein Lease shall be terminated as to the portion taken back by Landlord in accordance with the provisions contained hereinafter in this paragraph, but shall remain in full force and effect as to any portion remaining and not taken
back. In the alternative, however, Landlord shall have the right at Landlord’s election either (i) to permit any assignment or sublease of the said Upper Floor Premises or any portion thereof requested on the part of Tenant to be consummated
without exercising Call Rights and taking back any such portion of the said Premises; or (ii) to withhold consent to any such assignment or sublease without exercising Call Rights and taking back any portion of the said Upper Floor Premises, all in
accordance with the provisions contained hereinafter in this paragraph. 
 
The provisions of this paragraph E. shall operate in such manner that if Tenant shall intend to assign this Lease, as amended, in connection with the Upper Floor Premises or to sublet all or any portion thereof, Tenant shall
notify Landlord in writing of such intent in sufficient detail so as to apprise Landlord of the business and other terms and conditions of any such intended assignment or sublease, including fiscal information and data with respect to the proposed
assignee or sublessee in such detail as Landlord shall reasonably require. Landlord shall thereafter have fifteen (15) business days in which to notify Tenant in writing of its election as to whether (a) Landlord shall exercise its Call Rights and
take back the said Premises or such portion thereof as intended by Tenant to be subleased; or (b) whether Landlord shall waive such Call Rights and permit any such assignment or sublease of the said Premises or any portion thereof to be consummated
by Tenant; or (c) whether Landlord shall withhold its consent to any such assignment or sublease, setting forth in its notice the reasons therefor. 
 
In the event that Landlord shall exercise its Call Rights, the herein Lease with respect to the Upper Floor Premises or such lesser
portion thereof as to which Landlord’s Call Rights shall appertain, shall terminate as of a date certain to be identified by Landlord in the above referenced notice to Tenant. 
 
In the event of a permitted assignment or sublease, Tenant shall be entitled to consummate such assignment or
sublease transaction on the terms outlined in Tenant’s notice of request to Landlord. Notwithstanding any such permitted assignment or sublease, Tenant shall remain liable hereunder to perform all duties and obligations of Tenant, mitigated
only to the extent of actual and timely performance on the part of assignee or sublessee. Any Base Rent and/or Additional Rent or any other manner of consideration paid by any assignee or sublessee in excess of the value of that being paid by Tenant
hereunder, after deduction of all reasonable costs of effecting such sublease or assignment including reasonable fees of counsel, shall be shared equally by Landlord and Tenant, and Landlord’s share as aforesaid shall be tendered by Tenant to
Landlord periodically from time to time within ten (10) days of receipt by Tenant thereof. 
 
 

4 

 
In the event
that Landlord shall withhold its consent to any such assignment or sublease, then in such event this Lease and Tenant’s obligations hereunder shall remain in full force and effect. Landlord agrees that any request by Tenant for the consent of
Landlord to any such assignment or sublease shall not be unreasonably withheld, delayed or conditioned. 
 
The provisions of the herein paragraph E. shall supersede and take priority over the provisions of paragraph A., B., C. and D. hereinabove
with respect to the Upper Floor Premises.” 
 
5.    Article 36., Brokerage, is hereby amended by the addition thereto of a new paragraph which paragraph shall stipulate the following: 
 
“Further notwithstanding the foregoing, Landlord and Tenant covenant and agree to and with each other
that no broker is recognized as being responsible for consummation of the herein Fifth Amendment or the extension of the Term hereof with respect to those portions of the Premises described hereinabove. Landlord and Tenant mutually agree to
indemnify the other and to hold the other harmless from all suits, claims and demands brought by any party for brokerage commission with respect to the herein Fifth Amendment and the transactions described herein.” 
 
6. Ratification. The terms, conditions and provisions
of said Lease Agreement as amended by the terms, conditions and provisions of the First Amendment, the Second Amendment, the Third Amendment and the Fourth Amendment are hereby ratified and confirmed in all respects except as amended by the terms,
conditions and provisions of the herein Fifth Amendment. 
 
7. Conflict. In the event of any conflict between the terms, conditions and provisions of this Fifth Amendment and the terms, conditions and provisions of said Lease Agreement, as amended by the said First Amendment, the said
Second Amendment, the said Third Amendment and the said Fourth Amendment, then in such event the terms, conditions and provisions of this Fifth Amendment shall govern and prevail in all respects. 
 
 

5 

 
IN WITNESS
WHEREOF, the parties hereto have set their hands and seals as of the day and year first above written. 
 

	         In the presence
of:
	 	 	 	 LANDLORD
  
 FUSCO HARBOUR ASSOCIATES, LLC

	
	 	 	 Paula Gaudino

	 	 	 	 By:
	 	 Lynn Fusco Hughes

	 	 	 	 	 	 	 	 	 Duly Authorized

 

	
	 	 	 Brenna Anz

	 	 	 	 By:
	 	 Edmund J. Fusco, Jr.

	 	 	 	 	 	 	 	 	 Duly Authorized

 

	
	 	 	 Paula Gaudino

	 	 	 

 

	
	 	 	 Brenna Anz

	 	 	 

 

	         In the presence
of:
	 	 	 	 TENANT
  
 CURAGEN CORPORATION

	
	 	 	 Lana Porter Schmitz

	 	 	 	 By:
	 	 David M. Wurzer

	 	 	 	 	 	 	 	 	 Its EVP & CFO
 Duly Authorized

 

	
	 	 	 Wendy F. Bristow

	 	 	 

 

6 

 
STATE OF CONNECTICUT)

) ss.: New Haven; March 19, 2002 
COUNTY OF NEW HAVEN) 
 
Personally appeared, Lynn Fusco Hughes, duly authorized , of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be her free act and deed and the free act and deed
of said company, before me. 
 

	
	 By:
	 	 Brenna Anz

	 	 	 Notary Public
 My Commission Expires: 3/31/06

 
STATE OF
CONNECTICUT) 
) ss.: New Haven; March 19, 2002 
COUNTY OF NEW HAVEN) 
 
Personally appeared, Edmund J. Fusco, Jr., duly authorized , of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be his free act and deed and the free
act and deed of said company, before me. 
 

	
	 By:
	 	 Brenna Anz

	 	 	 Notary Public
 My Commission Expires: 3/31/06

 
STATE OF
CONNECTICUT) 
) ss.: 
COUNTY OF NEW HAVEN) 
 
Personally
appeared, Dave M. Wurzer, EVP & CFO of CURAGEN CORPORATION, signer and sealer of the foregoing instrument, and acknowledged the same to be his/her free act and deed and the free act and deed of said corporation, before me. 
 

	
	 By:
	 	 Terrie B. Atkinson

	 	 	 Notary Public
 My Commission Expires: 11/30/04

 

7 

 
SIXTH AMENDMENT
TO 
LEASE AGREEMENT 
 
FUSCO HARBOUR ASSOCIATES, LLC 
LANDLORD 
 
AND 
 
CURAGEN CORPORATION 
TENANT 
 
LONG WHARF MARITIME CENTER 
BUILDING 
555 LONG WHARF DRIVE 
NEW HAVEN, CONNECTICUT 
 
DATE: MAY
     , 2002 

 
SIXTH
AMENDMENT TO LEASE AGREEMENT 
 
THIS SIXTH
AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Sixth Amendment”) is made as of the 8th day of May, 2002 by and between FUSCO HARBOUR ASSOCIATES, LLC, a Connecticut limited liability company, with offices and a principal
place of business c/o The Fusco Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511 (said Fusco Harbour Associates, LLC, its successors and assigns hereinafter referred to as the “Landlord”) and CURAGEN CORPORATION, a Delaware
corporation with an office at 555 Long Wharf Drive, New Haven, Connecticut 06511 (said CuraGen Corporation, its successors and assigns hereinafter referred to as the “Tenant”). 
 
WITNESSETH: That 
 
WHEREAS, Landlord and Tenant entered into that certain Lease Agreement dated December 23, 1996 (the
“Lease”) whereunder Landlord leased to Tenant and Tenant leased from Landlord twenty six thousand two hundred sixty six (26,266) rentable square feet of floor area located on the eleventh floor of Landlord’s Building (the
“Initial Premises”) as described in said Lease; and 
 
WHEREAS, Landlord and Tenant entered into that certain First Amendment to Lease Agreement dated as of the 27th day of October, 1997 (the “First Amendment”) whereunder Landlord leased to Tenant and Tenant leased from
Landlord an additional five thousand three hundred ninety seven (5,397) rentable square feet of floor area located on the thirteenth floor of Landlord’s Building (the “First Expansion Premises”), on terms and conditions as described
in said First Amendment; and 
 
WHEREAS, Landlord
and Tenant entered into that certain Second Amendment to Lease Agreement dated as of the 31 st day of August, 1998 (the “Second Amendment”) whereunder Landlord leased to Tenant and Tenant leased from Landlord (i) an additional two thousand
nine hundred twenty eight (2,928) rentable square feet of floor area on the thirteenth floor of Landlord’s Building (the “Second Expansion Premises”) and (ii) an additional one thousand three hundred forty seven (1,347) rentable
square feet of floor area situated on the thirteen floor of Landlord’s Building (the “Third Expansion Premises”); and 
 
WHEREAS, Landlord and Tenant entered into that certain Third Amendment to Lease Agreement dated as of the 1st day of January, 2001,
whereunder Landlord leased to Tenant and Tenant leased from Landlord an additional four thousand five hundred twenty four (4,524) rentable square feet of floor area located on the ninth floor of Landlord’s Building (the “Fourth Expansion
Premises”); and 

 
WHEREAS,
Landlord and Tenant entered into that certain Fourth Amendment to Lease Agreement dated as of the 5th day of June, 2001, whereunder Landlord leased to Tenant and Tenant leased from Landlord an additional seven thousand two hundred ninety (7,290)
rentable square feet of floor area located on the ninth floor of Landlord’s Building (the “Fifth Expansion Premises”); and 
 
WHEREAS, Landlord and Tenant into that certain Fifth Amendment to Lease Agreement dated as of the 12th day of March, 2002, whereunder,
inter alia. the Term was modified, rental rates were modified and certain assignment rights were restricted; and 
 
WHEREAS, Tenant desires to expand its occupancy upon the fifth floor and upon the ninth floor of Landlord’s Building; and

 
WHEREAS, the parties desire to enter into this
Sixth Amendment to set forth the terms and conditions of their agreement in connection with the foregoing; 
 
NOW THEREFORE, in consideration of the mutual terms, conditions and covenants as contained in said Lease, as contained in said First
Amendment, as contained in said Second Amendment, as contained in the Third Amendment, as contained in the Fourth Amendment, as contained in the Fifth Amendment, and as contained in the herein Sixth Amendment, the parties hereto do hereby agree as
follows: 
 
1.    Article 1.,
Premises. is hereby amended by the addition thereto of a new paragraph A-5. to be inserted after paragraph A-4. now there appearing, which paragraph A-5. shall stipulate as follows: 
 
“A-5. In addition to the foregoing, effective June 1, 2002, Landlord does hereby lease to Tenant and
Tenant does hereby lease from Landlord (i) an additional five thousand two hundred seventy eight (5,278) rentable square feet of floor area situated on the fIfth floor of Landlord’s Building in the area designated on Exhibit B-5 annexed hereto
and made a part hereof (the “Sixth Expansion Premises”), and (ii) an additional two thousand (2,000) rentable square feet of floor area situated on the ninth floor of Landlord’s Building in the area designated on Exhibit B-6 annexed
hereto and made a part hereof (the “Seventh Expansion Premises”). The total rentable area leased to Tenant shall as of such date be fifty five thousand thirty (55,030) rentable square feet situated on respective floors as follows:

 

	 5th floor
	  	 5,278

	 9th floor
	  	 13,814

	 11th floor
	  	 26,266

	 13th floor
	  	 9,672

	 Total
	  	 55,030

 

2 

 
Whenever the
defmed term “Premises” shall be used hereinafter it shall, wherever the context may indicate or wherever proper reading may require, also be deemed to refer to the First Expansion Premises, the Second Expansion Premises, the Third
Expansion Premises, the Fourth Expansion Premises, the Fifth Expansion Premises, the Sixth Expansion Premises and the Seventh Expansion Premises in all respects as if initially the said First Expansion Premises, Second Expansion Premises, Third
Expansion Premises, Fourth Expansion Premises, Fifth Expansion Premises, Sixth Expansion Premises and Seventh Expansion Premises were fully includable within the intent of the defined tenn “Premises”, all until any relevant portion of the
Premises shall no longer be included hereunder due to tenn expiration or otherwise. 
 
2.    Article 3., Term, is hereby amended by the addition thereto of a new paragraph A- 6. to be inserted after paragraph A-5. now there appearing, which new paragraph A-6.
shall stipulate the following: 
 
“A-6. TO
HAVE AND HOLD the Sixth Expansion Premises and the Seventh Expansion Premises for a period and term commencing June 1,2002 (the “Sixth Expansion Premises Commencement Date and Seventh Expansion Premises Commencement Date”
respectively).” 
 
3.    Article 3., Term. is hereby further amended by the addition thereto of a new paragraph C-5. to be inserted after paragraph C-4. now there appearing which new paragraph C- 5. shall stipulate the following:

 
“C-5. Effective as of the date of the
herein Sixth Amendment and notwithstanding anything contained in the Lease, as amended, to the contrary, the term of this Lease, as amended, with respect to all portions of the Premises shall expire as follows: 
 

	 Location

	 	 Rentable
 Square Footage

	 	 Term
 Expiration Date

	 5th floor
	 	   5,278
	 	                     October 31, 2008

	 9th floor
	 	 13,814
	 	                     June 30, 2006

	 11th floor
	 	 26,266
	 	                     December 31, 2007

	 13th floor
	 	   9,672
	 	                     December 31, 2007

 
Holding
over beyond the foregoing Term Expiration Dates is strictly prohibited.” 
 
4.    Article 4., Rent and Rent Commencement. is hereby amended by the addition thereto of a new paragraph A-3. to be inserted after paragraph A-2. now there appearing, which
paragraph A-3. shall stipulate the following: 
 

3 

 
“A-3.
Notwithstanding anything contained in the foregoing paragraph A-2. to the contrary, commencing June 1, 2002 (prior to which time the rental structure set forth in the Fifth Amendment shall continue to be applicable), Tenant covenants and agrees to
pay to Landlord and Landlord shall be entitled to receive an annual base rental (“Base Rent”) during the following periods of time in the following amounts: 
 

	 Lease Period

	 	 Base Rent Per Square Foot

	 	 Total Annual Base Rent

	 	 Monthly Installments

	 A.    June 1,2002 through
         December 31, 2002
	 	             $21.501
             $22.502
             $25.003
	 	             $1,238,657.00
	 	             $103,221.42

	
	 B.    January 1, 2003 through
         June 30, 2006
	 	             $25.004
	 	             $1,375,750.00
	 	             $114,645.83

	
	 C.    July 1,2006 through
         December 31, 2007
	 	             $25.005
	 	             $1,030,400.00
	 	             $85,866.67

	
	 D.    January 1,2008 through
         October 31, 2008
	 	             $25.006
	 	             $131,950.00
	 	             $10,995.83

 
All such
Base Rent shall be paid on a monthly installment basis, in advance, on the first day of each month during the term hereof.” 
 
5.    Article 14., Construction, is hereby amended by the addition thereto of a new paragraph J. to appear
after paragraph I. which paragraph J. shall stipulate the following: 
 

	 	1.	 	With respect to 35,938 square feet (Initial, First, Second and Third Expansion Premises) 

 

	 	2.	 	With respect to 4,524 square feet (Fourth Expansion Premises) 

 

	 	3.	 	With respect to 14,568 square feet (Fifth, Sixth and Seventh Expansion Premises) 

 

	 	4.	 	With respect to entire Premises of 55,030 square feet 

 

	 	5.	 	With respect to all Premises excepting ninth floor Premises and thus 41,216 

 

	 	6.	 	With respect only to Fifth Floor Premises of 5,278 square feet 

 

4 

 
“J.    Notwithstanding anything contained herein to the contrary, the Sixth Expansion Premises and the Seventh Expansion Premises shall be delivered to Tenant and leased on an “as is” basis, and any
improvements to the Sixth Expansion Premises and the Seventh Expansion Premises shall be the sole responsibility of and at the cost of Tenant. If Tenant shall elect to make such improvements, Tenant shall comply in all respects with paragraph 6.D.
of the Lease set forth hereinabove.” 
 
6.
Article 36., Brokerage, is hereby amended by the addition thereto of a new paragraph which paragraph shall stipulate the following: 
 
“Further notwithstanding the foregoing, Landlord and Tenant covenant and agree to and with each other that no broker is recognized as
being responsible for consummation of the herein Sixth Amendment or the addition hereto of those portions of the Premises described hereinabove as the Sixth Expansion Premises and the Seventh Expansion Premises. Landlord and Tenant mutually agree to
indemnify the other and to hold the other harmless from all suits, claims and demands brought by any party for brokerage commission with respect to the herein Sixth Amendment and the transactions described herein.” 
 
7. Parking. Exhibit E, PARKING, NO. OF SPACES, is
hereby amended by inclusion of the following: 
 

	 Lease Period

	 	 Number of Unreserved
 Parking Spaces
 Allotted to
Tenant

	 A.    June 1, 2002 through
         June 30, 2006
	 	                         151

	
	 B.    June 30, 2006 through
         December 31, 2007
	 	                         113

	
	 C.    January 1, 2008 through
         October 31, 2008
	 	                           15

 
Two of the above spaces
shall be located in the “contractor lot”, so-called, located on the ground floor of the structured parking facility) until December 31, 2007. All such spaces shall be included in the Base Rent being paid by Tenant. Additional spaces may be
leased from time to time at then prevailing market rental rates, plus applicable sales taxes, and strictly subject to availability. 
 
8.    Ratification. The terms, conditions and provisions of said Lease Agreement as amended by the terms,
conditions and provisions of the First Amendment, the Second 
 

5 

 
Amendment, the Third
Amendment, the Fourth Amendment and the Fifth Amendment are hereby ratified and confmned in all respects except as amended by the terms, conditions and provisions of the herein Sixth Amendment. 
 
9.    Conflict. In the event of any
conflict between the terms, conditions and provisions of this Sixth Amendment and the terms, conditions and provisions of said Lease Agreement, as amended by the said First Amendment, the said Second Amendment, the said Third Amendment, the said
Fourth Amendment and the said Fifth Amendment, then in such event the terms, conditions and provisions of this Sixth Amendment shall govern and prevail in all respects. 
 
IN WITNESS WHEREOF, the parties hereto have set their hands and seals as of 
 

	         In the presence of: 
	 LANDLORD 

FUSCO HARBOUR ASSOCIATES, LLC 
 

	
	 	 	 Lisa Crosby

	 	 	 	 By:
	 	 Lynn Fusco Hughes

	 	 	  
 Brenna Anz

	 	 	 	 	 	 Lynn Fusco Hughes
 Duly Authorized

 

	
	 	 	 Lisa Crosby

	 	 	 	 By:
	 	 Edmund J. Fusco, Jr.

	 	 	  
 Brenna Anz

	 	 	 	 	 	 Edmund J. Fusco, Jr.
 Duly Authorized

 

	         In the presence of: 
	 TENANT 

CURAGEN CORPORATION 
 

	
	 	 	 Catherine Mugo

	 	 	 	 By:
	 	 David M. Wurzer

	 	 	  
 Lana Porter Schmitz

	 	 	 	 	 	 Its EVP & CFO
 Duly Authorized

 
STATE OF CONNECTICUT)

) ss.: New Haven; May 21, 2002 
COUNTY OF NEW HAVEN) 
 
Personally
appeared, Lynn Fusco Hughes, duly authorized of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be her free act and deed and the free act and deed of said company, before me. 
 

	 
	
	 By:
	 	 Brenna Anz

	 	 	 Notary Public
 My Commission Expires March 31, 2006

 
STATE OF
CONNECTICUT) 
) ss.: New Haven; May 21, 2002 
COUNTY OF NEW HAVEN) 
 
Personally appeared, Edmund J. Fusco, Jr., duly authorized of FUSCO HARBOUR ASSOCIATES, LLC, signer and sealer of the foregoing instrument, and acknowledged the same to be his free act and deed and the free act and deed of
said company, before me. 
 

	 
	
	 By:
	 	 Brenna Anz

	 	 	 Notary Public
 My Commission Expires March 31, 2006

 

7 

 
STATE OF CONNECTICUT)

) ss.: New Haven; 
COUNTY OF NEW HAVEN) 
 
Personally
appeared, David. M. Wurzer, EVP & CFO of CURAGEN CORPORATION, signer and sealer of the foregoing instrument, and acknowledged the same to be his/her free act and deed and the free act and deed of said corporation, before me. 
 

	 
	
	 By:
	 	 Terrie B. Atkinson

	 	 	 Notary Public
 My Commission Expires November 30, 2004

 

8

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