Document:

EX-10.1

September 3, 2014

Juan Acosta Reboyras

Address Omitted

Dear Mr. Acosta Reboyras:

The Board of Directors (the “Board”) of First BanCorp (the “Corporation”) and FirstBank Puerto
Rico(the “Bank”) is pleased to offer you the position as a Director of the Board of the Corporation
and the Bank, which offer is contingent on the absence of any objection or reservation by any
applicable regulatory authority. Your service as a Director of the Bank shall be effective as of
August 28, 2014 (the “Effective Date”), the date of effectiveness of this offer letter (the “Offer
Letter”). Your service as a Director of the Corporation shall be effective as soon as possible
after the fulfillment of the prior notice requirements of 12 U.S.C. § 1831i and Subpart H of
Regulation Y promulgated by the Board of Governors of the Federal Reserve System.

The following are the detailed terms of this Offer Letter:

	1.	 	Position/Services.

	 	a.	 	You will be expected to devote a reasonable amount of your business time to
your services to the Bank pursuant to this Offer Letter commensurate with your role as
a member of the Board and as a member or Chair of a Board committee and you agree that
you will not, without the prior written consent of the Bank, directly or indirectly,
provide any material services to any other banking entity which competes in any
material respect with the Bank and its subsidiaries until the earlier of (i) the
termination of your services to the Bank pursuant to this Offer Letter, and (ii) your
resignation as Director (such date, the “Termination Date”), provided however that any
services provided by you to any other banking entity which you have disclosed to the
Bank prior to the presentation of this Offer Letter and which continues to be provided
as of its execution is not prohibited pursuant to this section and shall not require
the prior written consent of the Bank. You may resign as a member of the Board at any
time upon written notice to its Chairman.

	 	b.	 	You shall render services as a member of the Board, as well as a member of any
other committee which you may be appointed to by the Board during your services as a
member of the Board, which may include the appointment as a committee chair. You shall
attend and participate to the maximum extent practicable in such number of meetings of
the Board and of the committee(s) of which you are a member as regularly or specially
called.

	2.	 	Term. Your term as Director shall continue until your successor is duly elected and
qualified or until any resignation by you shall be effective. The position shall be up for
re-election each year at the annual shareholders’ meeting and upon re-election, the terms and
provisions of this Offer Letter (as modified from time to time) shall remain in full force and
effect.

	3.	 	Fees and Compensation.

	 	a.	 	Annual Director’s Fees. Commencing on the Effective Date, you will be paid
fees for your services as a Director in a total amount equal to $100,000 per year (such
amount, the “Annual Fee”). The Annual Fee shall be payable seventy five percent (75%)
in cash (the “Annual Retainer”) and twenty five percent (25%) in the form of an annual
grant of restricted stock (the “Restricted Stock”), under the First BanCorp 2008
Omnibus Incentive Plan, as amended on December 9, 2011. The cash Annual Retainer shall
be paid in equal installments on a monthly basis over a twelve-month period. The
Restricted Stock shall be awarded at the beginning of each twelve-month period during
which you are a Director and shall be subject to a twelve-month vesting period. In
addition, you may receive additional compensation in the form of retainers depending
upon the Board committees which you may be appointed to by the Board during your
services as a member of the Board as follows, subject to the right of the Board to
change such fee structure at its discretion based on changed circumstances:

	 	 	 	 	 	 	 	 	 
	 
	 	Committee Chair	 	Committee Member
	Committee
	 	Retainer	 	Retainer
	 
	 	 	 	 	 	 	 	 
	Audit Committee
	 	$	25,000	 	 	$	5,000	 
	 
	 	 	 	 	 	 	 	 
	Compensation and Benefits Committee
	 	$	5,000	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Corporate Governance and
Nominating Committee
	 	$	5,000	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Asset/Liability Committee
	 	$	5,000	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Credit Committee
	 	$	25,000	 	 	$	5,000	 
	 
	 	 	 	 	 	 	 	 
	Compliance Committee
	 	$	5,000	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Risk Management Committee
	 	$	25,000	 	 	$	5,000	 
	 
	 	 	 	 	 	 	 	 

You shall also be entitled to a one-time grant of $150,000 payable in restricted
stock (the “Additional Restricted Stock”). The Additional Restricted Stock shall
vest solely on the basis of the passage of time ratably over a five-year period
commencing on the Effective Date.

	 	b.	 	Taxes. You are responsible for paying all Federal, state, and local income or
business taxes, including estimated taxes, self-employment and any other taxes, fees,
additions to tax, interest, or penalties, which may be assessed, imposed, or incurred
as a result of any amounts paid to you pursuant to this Offer Letter. The Bank may
withhold or cause to be withheld from any Annual Fee any Federal, Puerto Rico, state or
local taxes required by law to be withheld with respect to such Annual Fee. By
acceptance of this Agreement, Director agrees to such deductions.

	4.	 	Reimbursement of Board Meeting/Committee Expenses: D&O Insurance and Indemnification.

	 	a.	 	You shall be entitled to receive reimbursement for all reasonable and
substantiated (i) expenses incurred by you in connection with your attending each Board
meeting and any director education meetings, including reasonable and substantiated
business class or equivalent travel expenses and meals and lodging, and (ii) legal
expenses incurred by you in connection with the negotiation of this Offer Letter. All
expenses incurred under this Section 4 will be reimbursed in accordance with the
applicable policies and procedures of the Bank; provided, however, that any amounts
reimbursed in one taxable year will not affect the amounts eligible for reimbursement
by the Bank in a different taxable year, and all reimbursement requests must be
submitted by you no later than December 31 of the calendar year following the calendar
year in which the expense was incurred.

	 	b.	 	The Bank shall, at its expense, purchase and maintain director’s and officer’s
(“D&O”) insurance in an amount comparable to the amount of D&O insurance provided by
chartered banks with similar total assets and of a similar size and complexity to the
Bank (but in no event less than $10 million), to protect itself and you, as a Director
serving at the request of the Bank, against any expense, liability, or loss, whether or
not the Bank would have the power to indemnify you against such expense, liability, or
loss under applicable law. Such insurance shall be written by an insurer or insurers
admitted to issue such insurance in Puerto Rico and holding a financial strength
rating (“FSR”) of not less than B+ as such FSR is assigned by Best’s and shall be on
terms and conditions as shall be customary in the current market from time to time.
Such coverage shall include a “Side A” coverage available to directors in an amount
comparable to that obtained by other comparable institutions (but in no event less than
$10 million). The Bank shall purchase such coverage on a basis that will provide
protection to you not only during the time of your service as a director of the Board
but also for six years after such service shall terminate for any reason. The Bank
will provide copies of its D&O insurance policies to you upon request and will promptly
advise you of any changes that may occur in its existing coverages.

	 	c.	 	As a Director serving at the request of the Bank, you shall be indemnified by
the Bank to the fullest extent permitted by applicable law against judgments, penalties
(including excise and similar taxes and punitive damages), fines, settlements, and
reasonable expenses (including reasonable attorneys’ and expert witness fees) actually
incurred by you in connection with any actual or threatened proceeding (a “Proceeding”)
relating to or arising from your service as a member of the Board or any committee
thereof with any such expenses being advanced to you within 30 days of your written
request therefore; provided that in any matter covered by paragraph (2) of Article
Ninth of the Articles of Incorporation of the Bank your conduct is not finally adjudged
in a non-appealable decision by a court of competent jurisdiction to have constituted
fraud, bad faith, gross negligence or willful and knowing violation of any law
applicable to the Bank or your service as a director or member of a committee of the
Board, in which case there shall be no indemnification and you shall return any
advances to the Bank (a “Non-Indemnifiable Claim”); provided, further, however, that
you shall be entitled to indemnification in any circumstance in which you acted or
failed to act in reliance upon advice of counsel to the Bank or the Board or any
committee thereof or the court in which such action was brought shall determines upon
application, that despite the adjudication of liability but in view of all the
circumstances of the case, you are fairly and reasonably entitled to indemnity for such
expenses which the court shall deem proper. Your entitlement to indemnification under
this Section 4.c. shall not be limited to your entitlement to protection under any
applicable insurance coverage and to any other indemnification or payment you may be
entitled to under the circumstances under the Bank’s articles of incorporation or
by-laws or under any other agreement. Notwithstanding the foregoing, the Bank shall
not be obligated to provide any indemnification or advancement of expenses when (i) a
Proceeding is between the Bank and you (provided that you shall be entitled to such
indemnification in respect of any action brought by or in the right of the Bank by any
shareholder thereof, i.e., a derivative action, and in respect of any action brought by
you to establish your right to indemnification hereunder or otherwise; providing any
such actions do not constitute a Non-Indemnifiable Claim); or (ii) prohibited by
applicable law or regulation, including 12 C.F.R. part 359.

	 	d.	 	Each and every provision of this Section 4 is separate and distinct so that if
any provision hereof shall be held to be invalid or unenforceable for any reason, such
invalidity or unenforceability shall not affect the validity or enforceability of any
other provision hereof. To the extent required, any provision of this Section 4 may be
modified by a court of competent jurisdiction to preserve its validity and to provide
you with the broadest possible indemnification permitted under Puerto Rican law.

	 	e.	 	If any provision of this Section 4 is invalidated on any ground by any court of
competent jurisdiction, the Bank shall nevertheless indemnify you as to any expenses,
judgments, fines, penalties or excise taxes incurred with respect to any Proceeding to
the full extent permitted by any provision hereof that has not been invalidated or by
any other applicable provision of Puerto Rico law.

	5.	 	General Provisions.

	 	a.	 	This Offer Letter supersedes any other agreements or promises made to you by
anyone at the Bank, whether oral or written, and, subject to approval by the Board,
comprises the final, complete, and exclusive agreement between you and the Bank.

	 	b.	 	This Offer Letter shall be governed by the laws of the Commonwealth of Puerto
Rico, without regard to its principles of conflicts or choices of laws.

	 	c.	 	This Offer Letter may be modified only by a written instrument duly executed by
you and an authorized representative of the Bank.

	 	d.	 	This Offer Letter may be executed by the parties in separate counterparts, each
of which, when so executed and delivered, shall be an original, but all of which, when
taken as a whole, shall constitute one and the same instrument.

	 	e.	 	Any notices that are required to be given pursuant to this Offer Letter must be
in writing and may be given by personal delivery, registered or certified mail (postage
prepaid, return receipt requested), facsimile, courier, or overnight mail delivery to
the following addresses:

	 	 	 
	To the Company:
	 	First BanCorp

PO Box 9146

San Juan, PR 00907-0146

	To You:
	 	Juan Acosta Reboyras

Address Omitted

	 	f.	 	The Bank and you hereby consent to the jurisdiction of the Federal and State
courts of the Commonwealth of Puerto for the purpose of hearing any Proceeding between
you and the Bank arising hereunder or in respect to your service as a member of the
Board or any committee thereof.

	 	g.	 	This Offer Letter shall be binding upon, and shall inure to the benefit of you
and your heirs, executors and administrators, whether or not you have ceased to be a
director, and the Bank and its successors and assigns.

(SIGNATURE PAGE FOLLOWS)

1

Please sign and date this Offer Letter below and return it to the Bank as soon as possible but
in no event later than September 3, 2014, to indicate your agreement to the terms and conditions
described herein.

We look forward to your favorable reply and to a productive and enjoyable work relationship.

Sincerely,

First BanCorp

By: /s/ Roberto Herencia 

Roberto Herencia

Chairman of the Board

Agreed and Accepted:

By: /s/ Juan Acosta Reboyras 

Juan Acosta Reboyras

2Exhibit 4.1

 

Warrant Certificate No. A-__

 

NEITHER THE SECURITIES REPRESENTED BY THIS
CERTIFICATE NOR THE SECURITIES ISSUABLE UPON THE EXERCISE OF THIS WARRANT HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE “ACT”), OR ANY STATE SECURITIES LAWS, AND NEITHER SUCH SECURITIES NOR ANY INTEREST THEREIN MAY BE OFFERED,
SOLD, ASSIGNED OR OTHERWISE TRANSFERRED UNLESS (1) A REGISTRATION STATEMENT WITH RESPECT THERETO IS EFFECTIVE UNDER THE ACT AND
ANY APPLICABLE STATE SECURITIES LAWS, OR (2) AN EXEMPTION FROM SUCH REGISTRATION EXISTS AND THE COMPANY RECEIVES AN OPINION OF
COUNSEL TO THE HOLDER OF SUCH SECURITIES, WHICH COUNSEL AND OPINION ARE SATISFACTORY TO THE COMPANY, THAT SUCH SECURITIES MAY BE
OFFERED, SOLD, PLEDGED, ASSIGNED OR TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT UNDER THE
ACT OR APPLICABLE STATE SECURITIES LAWS.

 

	Effective Date: April 11, 2014	Void After: April 11, 2019

 

CORBUS PHARMACEUTICALS HOLDINGS, INC.

 

WARRANT TO PURCHASE COMMON STOCK

 

Corbus Pharmaceuticals
Holdings, Inc., a Delaware corporation (the “Company”), for value received on April 11, 2014 (the “Effective
Date”), hereby issues to [          ] (the “Holder”
or “Warrant Holder”) this Warrant (the “Warrant”) to purchase, [        ]
shares (each such share as from time to time adjusted as hereinafter provided being a “Warrant Share” and all
such shares being the “Warrant Shares”) of the Company’s Common Stock (as defined below), at the Exercise
Price (as defined below), as adjusted from time to time as provided herein, on or before April 11, 2019 (the “Expiration
Date”), all subject to the following terms and conditions.  This Warrant is one of a series of warrants of
like tenor that have been issued in connection with the Company’s private offering solely to accredited investors of units
in accordance with, and subject to, the terms and conditions described in the Subscription Agreement, attached to the Confidential
Private Placement Memorandum of the Company dated March 27, 2014, as the same may be amended and supplemented from time to time
(the “Subscription Agreement” and the “Private Placement Memorandum” respectively).  

 

As used in this Warrant,
(i) “Business Day” means any day other than Saturday, Sunday or any other day on which commercial banks in the
City of New York, New York, are authorized or required by law or executive order to close; (ii) “Common Stock”
means the common stock of the Company, par value $0.0001 per share, including any securities issued or issuable with respect thereto
or into which or for which such shares may be exchanged for, or converted into, pursuant to any stock dividend, stock split, stock
combination, recapitalization, reclassification, reorganization or other similar event; (iii) “Exercise Price”
means $1.00 per share of Common Stock, subject to adjustment as provided herein; (iv) “Trading Day” means any
day on which the Common Stock is traded (or available for trading) on its principal trading market; (v) “Affiliate”
means any person that, directly or indirectly, through one or more intermediaries, controls, is controlled by, or is under common
control with, a person, as such terms are used and construed in Rule 144 promulgated under the Securities Act of 1933, as amended
(the “Securities Act”) and (vi) “Warrantholders” means the holders of Warrants issued pursuant
to the Subscription Agreement and Private Placement Memorandum.

 

    	1

    	 

    

 

1.           DURATION
AND EXERCISE OF WARRANTS

 

(a)          Exercise
Period.  The Holder may exercise this Warrant in whole or in part on any Business Day on or before 5:00 P.M., Eastern
Time, on the Expiration Date, at which time this Warrant shall become void and of no value.

 

(b)          Exercise
Procedures.

 

(i)          While
this Warrant remains outstanding and exercisable in accordance with Section 1(a), in addition to the manner set forth in Section
1(b)(ii) below, the Holder may exercise this Warrant in whole or in part at any time and from time to time by:

 

(A)         delivery
to the Company of a duly executed copy of the Notice of Exercise attached as Exhibit A;

 

(B)         surrender
of this Warrant to the Secretary of the Company at its principal offices or at such other office or agency as the Company may specify
in writing to the Holder; and

 

(C)         payment
of the then-applicable Exercise Price per share multiplied by the number of Warrant Shares being purchased upon exercise of the
Warrant (such amount, the “Aggregate Exercise Price”) made in the form of cash, or by certified check, bank
draft or money order payable in lawful money of the United States of America or in the form of a Cashless Exercise to the extent
permitted in Section 1(b)(ii) below.

 

(ii)         In
addition to the provisions of Section 1(b)(i) above, if any time after the Effectiveness Deadline (as defined in the Registration
Rights Agreement of even date herewith, by and among the Company, the Holder and the other subscribers of the Company’s securities
pursuant to the Subscription Agreements (the “Registration Rights Agreement”)), a registration statement covering
the resale of the Warrant Shares by the Holder is not effective with the Securities and Exchange Commission (the “SEC”),
the Holder may, in its sole discretion, exercise all or any part of the Warrant in a “cashless” or “net-issue”
exercise (a “Cashless Exercise”) by delivering to the Company (1) the Notice of Exercise and (2) the original
Warrant, pursuant to which the Holder shall surrender the right to receive upon exercise of this Warrant, a number of Warrant Shares
having a value (as determined below) equal to the Aggregate Exercise Price, in which case, the number of Warrant Shares to be issued
to the Holder upon such exercise shall be calculated using the following formula:

 

	 	X	=	Y * (A - B)	 
	 	 	 	A	 

 

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	with:	X =	the number of Warrant Shares to be issued to the Holder
	 	 	 
	 	Y =	the number of Warrant Shares with respect to which the Warrant is being exercised
	 	 	 
	 	A =	the fair value per share of Common Stock on the date of exercise of this Warrant
	 	 	 
	 	B =	the then-current Exercise Price of the Warrant

 

Solely for the purposes
of this paragraph, “fair value” per share of Common Stock shall mean the average Closing Price (as defined below)
per share of Common Stock for the twenty (20) trading days immediately preceding the date on which the Notice of Exercise is deemed
to have been sent to the Company.  “Closing Price” means, for any date, the price determined by the
first of the following clauses that applies:  (a) if the Common Stock is then listed or quoted on the New York Stock
Exchange, the NYSE MKT, the NASDAQ Global Select Market, the NASDAQ Global Market or the NASDAQ Capital Market or any other national
securities exchange, the closing price per share of the Common Stock for such date (or the nearest preceding date) on the primary
eligible market or exchange on which the Common Stock is then listed or quoted; (b) if prices for the Common Stock are then quoted
on the OTC Bulletin Board or any tier of the OTC Markets, the closing bid price per share of the Common Stock for such date (or
the nearest preceding date) so quoted; or (c) if prices for the Common Stock are then reported in the “Pink Sheets”
published by the National Quotation Bureau Incorporated (or a similar organization or agency succeeding to its functions of reporting
prices), the most recent closing bid price per share of the Common Stock so reported.  If the Common Stock is not publicly
traded as set forth above, the “fair value” per share of Common Stock shall be reasonably and in good faith determined
by the Board of Directors of the Company as of the date which the Notice of Exercise is deemed to have been sent to the Company.

 

Notwithstanding the
foregoing, provided that a registration statement (including any post-effective amendment) covering the resale of the Warrant Shares
by the Holder has (x) been declared effective by the SEC and (y) has been effective for an aggregate period of one year, any Cashless
Exercise right hereunder shall thereupon terminate.

 

For purposes of Rule
144 promulgated under the Securities Act, it is intended, understood and acknowledged that the Warrant Shares issued in a cashless
exercise transaction shall be deemed to have been acquired by the Holder, and the holding period for such shares shall be deemed
to have commenced, on the date this Warrant was originally issued.

 

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(iii)        Upon
the exercise of this Warrant in compliance with the provisions of this Section 1(b), and except as limited pursuant to the last
paragraph of Section 1(b)(ii), the Company shall promptly issue and cause to be delivered to the Holder a certificate for the Warrant
Shares purchased by the Holder.  Each exercise of this Warrant shall be effective immediately prior to the close of business
on the date (the “Date of Exercise”) that the conditions set forth in Section 1(b) have been satisfied, as the
case may be.  On the first Business Day following the date on which the Company has received each of the Notice of Exercise
and the Aggregate Exercise Price (or notice of a Cashless Exercise in accordance with Section 1(b)(ii)) (the “Exercise
Delivery Documents”), the Company shall transmit an acknowledgment of receipt of the Exercise Delivery Documents to the
Company’s transfer agent (the “Transfer Agent”). On or before the third Business Day following the date
on which the Company has received all of the Exercise Delivery Documents (the “Share Delivery Date”), the Company
shall (X) provided that the Transfer Agent is participating in The Depository Trust Company (“DTC”) Fast Automated
Securities Transfer Program, upon the request of the Holder, credit such aggregate number of shares of Common Stock to which the
Holder is entitled pursuant to such exercise to the Holder’s or its designee’s balance account with DTC through its
Deposit Withdrawal Agent Commission system, or (Y) if the Transfer Agent is not participating in the DTC Fast Automated Securities
Transfer Program, issue and dispatch by overnight courier to the address as specified in the Notice of Exercise, a certificate,
registered in the Company’s share register in the name of the Holder or its designee, for the number of shares of Common
Stock to which the Holder is entitled pursuant to such exercise.  Upon delivery of the Exercise Delivery Documents, the
Holder shall be deemed for all corporate purposes to have become the holder of record of the Warrant Shares with respect to which
this Warrant has been exercised, irrespective of the date of delivery of the certificates evidencing such Warrant Shares.

 

(iv)        If
the Company shall fail for any reason or for no reason to issue to the Holder, within three (3) Business Days of receipt of the
Exercise Delivery Documents, a certificate for the number of shares of Common Stock to which the Holder is entitled and register
such shares of Common Stock on the Company’s share register or to credit the Holder’s balance account with DTC for
such number of shares of Common Stock to which the Holder is entitled upon the Holder’s exercise of this Warrant, and if
on or after such Business Day the Holder purchases (in an open market transaction or otherwise) shares of Common Stock to deliver
in satisfaction of a sale by the Holder of shares of Common Stock issuable upon such exercise that the Holder anticipated receiving
from the Company (a “Buy-In”), then the Company shall, (A) pay in cash to the Holder the amount, if any, by
which (x) the Holder’s total purchase price (including brokerage commissions, if any) for the shares of Common Stock so purchased
(the “Buy-In Amount”) plus the amount paid by the Holder to the Company as the exercise price for the Warrant
Shares exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares that the Company was required to deliver
to the Holder in connection with the exercise at issue times (2) the price at which the sell order giving rise to such purchase
obligation was executed, and (B) at the option of the Holder, either reinstate the portion of the Warrant and equivalent number
of Warrant Shares for which such exercise was not honored or deliver to the Holder the number of shares of Common Stock that would
have been issued had the Company timely complied with its exercise and delivery obligations hereunder.  For example,
if the Holder purchases Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect to an attempted exercise
of shares of Common Stock, and paid the Company $5,000 as the exercise price, the Holder’s cash outlay would be a total of
$16,000; and if the aggregate sales price of the shares giving rise to such Buy-In obligation was $10,000, under clause (A) of
the immediately preceding sentence the Company shall be required to pay the Holder $6,000. The Holder shall provide the Company
written notice indicating the amounts payable to the Holder in respect of the Buy-In and, upon request of the Company, evidence
of the amount of such loss.  Nothing herein shall limit a Holder’s right to pursue any other remedies available
to it hereunder, at law or in equity including, without limitation, a decree of specific performance and/or injunctive relief with
respect to the Company’s failure to timely deliver certificates representing shares of Common Stock upon exercise of the
Warrant as required pursuant to the terms hereof.

 

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(c)          Partial
Exercise.  This Warrant shall be exercisable, either in its entirety or, from time to time, for part only of the
number of Warrant Shares referenced by this Warrant. If this Warrant is submitted in connection with any exercise pursuant to Section
1 and the number of Warrant Shares represented by this Warrant submitted for exercise is greater than the actual number of Warrant
Shares being acquired upon such an exercise, then the Company shall as soon as practicable and in no event later than five
(5) Business Days after any exercise and at its own expense, issue a new Warrant of like tenor representing the right to purchase
the number of Warrant Shares purchasable immediately prior to such exercise under this Warrant, less the number of Warrant Shares
with respect to which this Warrant is exercised.

 

(d)          Disputes.  In
the case of a dispute as to the determination of the Exercise Price or the arithmetic calculation of the Warrant Shares, the Company
shall promptly issue to the Holder the number of Warrant Shares that are not disputed and resolve such dispute in accordance with
Section 16.

 

2.           ISSUANCE
OF WARRANT SHARES

 

(a)          The
Company covenants that all Warrant Shares will, upon issuance in accordance with the terms of this Warrant, be (i) duly authorized,
fully paid and non-assessable, and (ii) free from all liens, charges and security interests, with the exception of claims arising
through the acts or omissions of any Holder and except as arising from applicable Federal and state securities laws.

 

(b)          The
Company shall register this Warrant upon records to be maintained by the Company for that purpose in the name of the record holder
of such Warrant from time to time. The Company may deem and treat the registered Holder of this Warrant as the absolute owner thereof
for the purpose of any exercise thereof, any distribution to the Holder thereof and for all other purposes.

 

(c)          The
Company will not, by amendment of its certificate of incorporation, by-laws or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance
or performance of any of the terms to be observed or performed hereunder by the Company, but will at all times in good faith assist
in the carrying out of all the provisions of this Warrant and in the taking of all action necessary or appropriate in order to
protect the rights of the Holder to exercise this Warrant, or against impairment of such rights.

 

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3.           ADJUSTMENTS
OF EXERCISE PRICE, NUMBER AND TYPE OF WARRANT SHARES

 

(a)          The
Exercise Price and the number of shares purchasable upon the exercise of this Warrant shall be subject to adjustment from time
to time upon the occurrence of certain events described in this Section 3; provided, that notwithstanding the provisions
of this Section 3, the Company shall not be required to make any adjustment if and to the extent that such adjustment would require
the Company to issue a number of shares of Common Stock in excess of its authorized but unissued shares of Common Stock, less all
amounts of Common Stock that have been reserved for issue upon the conversion of all outstanding securities convertible into shares
of Common Stock and the exercise of all outstanding options, warrants and other rights exercisable for shares of Common Stock.  If
the Company does not have the requisite number of authorized but unissued shares of Common Stock to make any adjustment, the Company
shall use its commercially best efforts to obtain the necessary stockholder consent to increase the authorized number of shares
of Common Stock to make such an adjustment pursuant to this Section 3.

 

(i)          Subdivision
or Combination of Stock. In case the Company shall at any time subdivide (whether by way of stock dividend, stock split or
otherwise) its outstanding shares of Common Stock into a greater number of shares, the Exercise Price in effect immediately prior
to such subdivision shall be proportionately reduced and the number of Warrant Shares shall be proportionately increased, and conversely,
in case the outstanding shares of Common Stock of the Company shall be combined (whether by way of stock combination, reverse stock
split or otherwise) into a smaller number of shares, the Exercise Price in effect immediately prior to such combination shall be
proportionately increased and the number of Warrant Shares shall be proportionately decreased.  The Exercise Price and
the Warrant Shares, as so adjusted, shall be readjusted in the same manner upon the happening of any successive event or events
described in this Section 3(a)(i).

 

(ii)         Dividends
in Stock, Property, Reclassification. If at any time, or from time to time, all of the holders of Common Stock (or any shares
of stock or other securities at the time receivable upon the exercise of this Warrant) shall have received or become entitled to  receive,
without payment therefore:

 

(A)         any
shares of stock or other securities that are at any time directly or indirectly convertible into or exchangeable for Common Stock,
or any rights or options to subscribe for, purchase or otherwise acquire any of the foregoing by way of dividend or other distribution,
or

 

(B)         additional
stock or other securities or property (including cash) by way of spin-off, split-up, reclassification, combination of shares or
similar corporate rearrangement (other than shares of Common Stock issued as a stock split or adjustments in respect of which shall
be covered by the terms of Section 3(a)(i) above),

 

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then and in each such case, the Exercise
Price and the number of Warrant Shares to be obtained upon exercise of this Warrant shall be adjusted proportionately, and the
Holder hereof shall, upon the exercise of this Warrant, be entitled to receive, in addition to the number of shares of Common Stock
receivable thereupon, and without payment of any additional consideration therefor, the amount of stock and other securities and
property (including cash in the cases referred to above) that such Holder would hold on the date of such exercise had such Holder
been the holder of record of such Common Stock as of the date on which holders of Common Stock received or became entitled to receive
such shares or all other additional stock and other securities and property.  The Exercise Price and the Warrant Shares,
as so adjusted, shall be readjusted in the same manner upon the happening of any successive event or events described in this Section
3(a)(ii).

 

(iii)        Reorganization,
Reclassification, Consolidation, Merger or Sale. If any recapitalization, reclassification or reorganization of the capital
stock of the Company, or any consolidation or merger of the Company with another corporation, or the sale of all or substantially
all of its assets or other transaction shall be effected in such a way that holders of Common Stock shall be entitled to receive
stock, securities, or other assets or property (an “Organic Change”), then, as a condition of such Organic Change,
lawful and adequate provisions shall be made by the Company whereby the Holder hereof shall thereafter have the right to purchase
and receive (in lieu of the shares of the Common Stock of the Company immediately theretofore purchasable and receivable upon the
exercise of the rights represented by this Warrant) such shares of stock, securities or other assets or property as may be issued
or payable with respect to or in exchange for a number of outstanding shares of such Common Stock equal to the number of shares
of such stock immediately theretofore purchasable and receivable assuming the full exercise of the rights represented by this Warrant.
In the event of any Organic Change, appropriate provision shall be made by the Company with respect to the rights and interests
of the Holder of this Warrant to the end that the provisions hereof (including, without limitation, provisions for adjustments
of the Exercise Price and of the number of shares purchasable and receivable upon the exercise of this Warrant and registration
rights) shall thereafter be applicable, in relation to any shares of stock, securities or assets thereafter deliverable upon the
exercise hereof. The Company will not affect any such consolidation, merger or sale unless, prior to the consummation thereof,
the successor corporation (if other than the Company) resulting from such consolidation or merger or the corporation purchasing
such assets shall assume by written instrument reasonably satisfactory in form and substance to the Holder executed and mailed
or delivered to the registered Holder hereof at the last address of such Holder appearing on the books of the Company, the obligation
to deliver to such Holder such shares of stock, securities or assets as, in accordance with the foregoing provisions, such Holder
may be entitled to purchase.  If there
is an Organic Change, then the Company shall cause to be mailed to the Holder at its last address as it shall appear on the books
and records of the Company, at least 10 calendar days before the effective date of the Organic Change, a notice stating the date
on which such Organic Change is expected to become effective or close, and the date as of which it is expected that holders of
the Common Stock of record shall be entitled to exchange their shares for securities, cash, or other property delivered upon such
Organic Change; provided, that the failure to mail such notice or any defect therein or in the mailing thereof shall not affect
the validity of the corporate action required to be specified in such notice.  The Holder is entitled to exercise this
Warrant during the 10-day period commencing on the date of such notice to the effective date of the event triggering such notice.  In
any event, the successor corporation (if other than the Company) resulting from such consolidation or merger or the corporation
purchasing such assets shall be deemed to assume such obligation to deliver to such Holder such shares of stock, securities or
assets even in the absence of a written instrument assuming such obligation to the extent such assumption occurs by operation of
law.  

 

    	7

    	 

    

 

(b)          Certificate
as to Adjustments. Upon the occurrence of each adjustment or readjustment pursuant to this Section 3, the Company at its expense
shall promptly compute such adjustment or readjustment in accordance with the terms hereof and furnish to each Holder of this Warrant
a certificate setting forth such adjustment or readjustment and showing in detail the facts upon which such adjustment or readjustment
is based. The Company shall promptly furnish or cause to be furnished to such Holder a like certificate setting forth: (i) such
adjustments and readjustments; and (ii) the number of shares and the amount, if any, of other property which at the time would
be received upon the exercise of the Warrant.

 

(c)          Certain
Events. If any event occurs as to which the other provisions of this Section 3 are not strictly applicable but the lack of
any adjustment would not fairly protect the purchase rights of the Holder under this Warrant in accordance with the basic intent
and principles of such provisions, or if strictly applicable would not fairly protect the purchase rights of the Holder under this
Warrant in accordance with the basic intent and principles of such provisions, then the Company's Board of Directors will, in good
faith, make an appropriate adjustment to protect the rights of the Holder; provided, that no such adjustment pursuant to
this Section 3(c) will increase the Exercise Price or decrease the number of Warrant Shares as otherwise determined pursuant to
this Section 3.

 

4.           REDEMPTION
OF WARRANTS  

 

(a)          General.  Prior
to the Expiration Date, the Company shall have the option, subject to the conditions set forth herein, to redeem all of the Warrants
then outstanding upon not less than thirty (30) days nor more than sixty (60) days prior written notice to the Warrant Holders
at any time provided that, at the time of delivery of such notice (i) there is an effective registration statement covering the
resale of the Warrant Shares, and (ii) the closing bid price of the Company’s Common Stock for each of the twenty (20) consecutive
Trading Days prior to the date of the notice of redemption is at least $2.00, as proportionately adjusted to reflect any stock
splits, stock dividends, combination of shares or like events.  It is contemplated that Aegis Capital Corp. will be retained
as solicitation agent in the event the Company elects to redeem the Warrants and shall be paid a fee of 5% of the gross proceeds
derived from the exercise of the Warrants in such event.  

 

(b)          Notice.  Notice
of redemption will be effective upon mailing in accordance with this Section and such date may be referred to below as the “Notice
Date.”  Notice of redemption shall be mailed by first class mail, postage prepaid, by the Company not less
than 30 days prior to the date fixed for redemption to the Holders of the Warrants to be redeemed at their last addresses as they
shall appear on the registration books. Any notice mailed in the manner herein provided shall be conclusively presumed to have
been duly given whether or not the Holder received such notice.

 

(c)          Redemption
Date and Redemption Price.  The notice of redemption shall state the date set for redemption, which date shall be
not less than thirty (30) days, or more than sixty (60) days, from the Notice Date (the “Redemption Date”).
The Company shall not mail the notice of redemption unless all funds necessary to pay for redemption of the Warrants to be redeemed
shall have first been set aside by the Company for the benefit of the Warrant Holders so as to be and continue to be available
therefor. The redemption price to be paid to the Warrant Holders will be $0.0001 for each share of Common Stock of the Company
to which the Warrant Holder would then be entitled upon exercise of the Warrant being redeemed, as adjusted from time to time as
provided herein (the “Redemption Price”).

 

    	8

    	 

    

 

(d)          Exercise.  Following
the Notice Date, the Warrant Holders may exercise their Warrants in accordance with Section 1 of this Warrant between the Notice
Date and 5:00 p.m. Eastern Time on the Redemption Date and such exercise shall be timely if the form of election to purchase duly
executed and the Warrant Exercise Price for the shares of Common Stock to be purchased are actually received by the Company at
its principal offices prior to 5:00 p.m. Eastern Time on the Redemption Date.

 

(e)          Mailing.
If any Warrant Holder does not wish to exercise any Warrant being redeemed, he should mail such Warrant to the Company at its principal
offices after receiving the notice of redemption. On and after 5:00 p.m. Eastern Time on the Redemption Date, notwithstanding that
any Warrant subject to redemption shall not have been surrendered for redemption, the obligation evidenced by all Warrants not
surrendered for redemption or effectively exercised shall be deemed no longer outstanding, and all rights with respect thereto
shall forthwith cease and terminate, except only the right of the holder of each Warrant subject to redemption to receive the Redemption
Price for each share of Common Stock to which he would be entitled if he exercised the Warrant upon receiving notice of redemption
of the Warrant subject to redemption held by him.

 

5.           TRANSFERS
AND EXCHANGES OF WARRANT AND WARRANT SHARES

 

(a)          Registration
of Transfers and Exchanges. Subject to Section 5(c), upon the Holder’s surrender of this Warrant, with a duly executed
copy of the Form of Assignment attached as Exhibit B, to the Secretary of the Company at its principal offices or at such
other office or agency as the Company may specify in writing to the Holder, the Company shall register the transfer of all or any
portion of this Warrant. Upon such registration of transfer, the Company shall issue a new Warrant, in substantially the form of
this Warrant, evidencing the acquisition rights transferred to the transferee and a new Warrant, in similar form, evidencing the
remaining acquisition rights not transferred, to the Holder requesting the transfer.

 

(b)          Warrant
Exchangeable for Different Denominations. The Holder may exchange this Warrant for a new Warrant or Warrants, in substantially
the form of this Warrant, evidencing in the aggregate the right to purchase the number of Warrant Shares which may then be purchased
hereunder, each of such new Warrants to be dated the date of such exchange and to represent the right to purchase such number of
Warrant Shares as shall be designated by the Holder. The Holder shall surrender this Warrant with duly executed instructions regarding
such re-certification of this Warrant to the Secretary of the Company at its principal offices or at such other office or agency
as the Company may specify in writing to the Holder.

 

(c)          Restrictions
on Transfers. This Warrant may not be transferred at any time without (i) registration under the Securities Act or (ii) an
exemption from such registration and a written opinion of legal counsel addressed to the Company that the proposed transfer of
the Warrant may be effected without registration under the Securities Act, which opinion will be in form and from counsel reasonably
satisfactory to the Company.

 

    	9

    	 

    

 

6.           MUTILATED
OR MISSING WARRANT CERTIFICATE

 

If this Warrant is
mutilated, lost, stolen or destroyed, upon request by the Holder, the Company will, at its expense, issue, in exchange for and
upon cancellation of the mutilated Warrant, or in substitution for the lost, stolen or destroyed Warrant, a new Warrant, in substantially
the form of this Warrant, representing the right to acquire the equivalent number of Warrant Shares; provided, that, as
a prerequisite to the issuance of a substitute Warrant, the Company may require satisfactory evidence of loss, theft or destruction
as well as an indemnity from the Holder of a lost, stolen or destroyed Warrant.

 

7.           PAYMENT
OF TAXES

 

The Company will pay
all transfer and stock issuance taxes attributable to the preparation, issuance and delivery of this Warrant and the Warrant Shares
(and replacement Warrants) including, without limitation, all documentary and stamp taxes; provided, however, that
the Company shall not be required to pay any tax in respect of the transfer of this Warrant, or the issuance or delivery of certificates
for Warrant Shares or other securities in respect of the Warrant Shares to any person or entity other than to the Holder.

 

8.           FRACTIONAL
WARRANT SHARES

 

No fractional Warrant
Shares shall be issued upon exercise of this Warrant. The Company, in lieu of issuing any fractional Warrant Share, shall round
up the number of Warrant Shares issuable to nearest whole share.

 

9.           NO
STOCK RIGHTS AND LEGEND

 

No holder of this Warrant,
as such, shall be entitled to vote or be deemed the holder of any other securities of the Company that may at any time be issuable
on the exercise hereof, nor shall anything contained herein be construed to confer upon the holder of this Warrant, as such, the
rights of a stockholder of the Company or the right to vote for the election of directors or upon any matter submitted to stockholders
at any meeting thereof, or give or withhold consent to any corporate action or to receive notice of meetings or other actions affecting
stockholders (except as provided herein), or to receive dividends or subscription rights or otherwise (except as provide herein).

 

Each certificate for
Warrant Shares initially issued upon the exercise of this Warrant, and each certificate for Warrant Shares issued to any subsequent
transferee of any such certificate, shall be stamped or otherwise imprinted with a legend in substantially the following form:

 

    	10

    	 

    

 

“THE SECURITIES
REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”),
OR ANY STATE SECURITIES LAWS, AND NEITHER SUCH SECURITIES NOR ANY INTEREST THEREIN MAY BE OFFERED, SOLD, PLEDGED, ASSIGNED OR OTHERWISE
TRANSFERRED UNLESS (1) A REGISTRATION STATEMENT WITH  RESPECT THERETO IS EFFECTIVE UNDER THE ACT AND ANY APPLICABLE STATE
SECURITIES LAWS, OR (2) AN EXEMPTION FROM SUCH REGISTRATION EXISTS AND THE COMPANY RECEIVES AN OPINION OF COUNSEL TO THE HOLDER
OF SUCH SECURITIES, WHICH COUNSEL AND OPINION ARE REASONABLY SATISFACTORY TO THE COMPANY, THAT SUCH SECURITIES MAY BE OFFERED,
SOLD, PLEDGED, ASSIGNED OR TRANSFERRED IN THE MANNER CONTEMPLATED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT OR  
APPLICABLE STATE SECURITIES LAWS.”

 

10.         REGISTRATION
RIGHTS

 

The Holder shall be
entitled to the registration rights as are contained in the Registration Rights Agreement, the provisions of which are deemed incorporated
herein by reference.  

 

11.         NOTICES

 

All notices, consents,
waivers, and other communications under this Warrant must be in writing and will be deemed given to a party when (a) delivered
to the appropriate address by hand or by nationally recognized overnight courier service (costs prepaid); (b) sent by facsimile
or e-mail with confirmation of transmission by the transmitting equipment; (c) received or rejected by the addressee, if sent by
certified mail, return receipt requested, if to the registered Holder hereof; or (d) seven days after the placement of the notice
into the mails (first class postage prepaid), to the Holder at the address, facsimile number, or e-mail address furnished by the
registered Holder to the Company in accordance with the Subscription Agreement by and between the Company and the Holder, or if
to the Company, to it at One Kendall Square, Bldg 200, Cambridge, MA 02139, Attn: Yuval Cohen, CEO (or to such other address, facsimile
number, or e-mail address as the Holder or the Company as a party may designate by notice the other party).

 

12.         SEVERABILITY

 

If a court of competent
jurisdiction holds any provision of this Warrant invalid or unenforceable, the other provisions of this Warrant will remain in
full force and effect. Any provision of this Warrant held invalid or unenforceable only in part or degree will remain in full force
and effect to the extent not held invalid or unenforceable.

 

13.         BINDING
EFFECT

 

This Warrant shall
be binding upon and inure to the sole and exclusive benefit of the Company, its successors and assigns, the registered Holder or
Holders from time to time of this Warrant and the Warrant Shares.

 

    	11

    	 

    

 

14.         SURVIVAL
OF RIGHTS AND DUTIES

 

This Warrant shall
terminate and be of no further force and effect on the earlier of 5:00 P.M., Eastern Time, on the Expiration Date or the date on
which this Warrant has been exercised in full.

 

15.         GOVERNING
LAW

 

This Warrant will be
governed by and construed under the laws of the State of New York without regard to conflicts of laws principles that would require
the application of any other law.

 

16.         DISPUTE
RESOLUTION

 

In the case of a dispute
as to the determination of the Exercise Price or the arithmetic calculation of the Warrant Shares, the Company shall submit the
disputed determinations or arithmetic calculations via facsimile within two Business Days of receipt of the Notice of Exercise
giving rise to such dispute, as the case may be, to the Holder. If the Holder and the Company are unable to agree upon such determination
or calculation of the Exercise Price or the Warrant Shares within three Business Days of such disputed determination or arithmetic
calculation being submitted to the Holder, then the Company shall, within two Business Days, submit via facsimile (a) the disputed
determination of the Exercise Price to an independent, reputable investment bank selected by the Company and approved by the Holder
or (b) the disputed arithmetic calculation of the Warrant Shares to the Company’s independent, outside accountant. The Company
shall cause at its expense the investment bank or the accountant, as the case may be, to perform the determinations or calculations
and notify the Company and the Holder of the results no later than ten (10) Business Days from the time it receives the disputed
determinations or calculations. Such investment bank’s or accountant’s determination or calculation, as the case may
be, shall be binding upon all parties absent demonstrable error.

 

17.         NOTICES
OF RECORD DATE

 

Upon (a) any establishment
by the Company of a record date of the holders of any class of securities for the purpose of determining the holders thereof who
are entitled to receive any dividend or other distribution, or right or option to acquire securities of the Company, or any other
right, or (b) any capital reorganization, reclassification, recapitalization, merger or consolidation of the Company with or into
any other corporation, any transfer of all or substantially all the assets of the Company, or any voluntary or involuntary dissolution,
liquidation or winding up of the Company, or the sale, in a single transaction, of a majority of the Company’s voting stock
(whether newly issued, or from treasury, or previously issued and then outstanding, or any combination thereof), the Company shall
mail to the Holder at least ten (10) Business Days, or such longer period as may be required by law, prior to the record date specified
therein, a notice specifying (i) the date established as the record date for the purpose of such dividend, distribution, option
or right and a description of such dividend, option or right, (ii) the date on which any such reorganization, reclassification,
transfer, consolidation, merger, dissolution, liquidation or winding up, or sale is expected to become effective and (iii) the
date, if any, fixed as to when the holders of record of Common Stock shall be entitled to exchange their shares of Common Stock
for securities or other property deliverable upon such reorganization, reclassification, transfer, consolation, merger, dissolution,
liquidation or winding up.

 

    	12

    	 

    

 

18.         RESERVATION
OF SHARES

 

The Company shall reserve
and keep available out of its authorized but unissued shares of Common Stock for issuance upon the exercise of this Warrant, free
from pre-emptive rights, such number of shares of Common Stock for which this Warrant shall from time to time be exercisable.  The
Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may be issued as provided herein
without violation of any applicable law or regulation. Without limiting the generality of the foregoing, the Company covenants
that it will use commercially reasonable efforts to take all such action as may be necessary or appropriate in order that the Company
may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant and use commercially
reasonable efforts to obtain all such authorizations, exemptions or consents, including but not limited to consents from the Company’s
stockholders or Board of Directors or any public regulatory body, as may be necessary to enable the Company to perform its obligations
under this Warrant.

 

19.         NO
THIRD PARTY RIGHTS

 

This Warrant is not
intended, and will not be construed, to create any rights in any parties other than the Company and the Holder, and no person or
entity may assert any rights as third-party beneficiary hereunder.

 

[SIGNATURE PAGE FOLLOWS]

 

    	13

    	 

    

 

IN WITNESS WHEREOF,
the Company has caused this Warrant to be duly executed as of the date first set forth above.

 

	 	CORBUS PHARMACEUTICALS HOLDINGS, INC.
	 	 	 
	 	By: 	 
	 	Name: Yuval Cohen
	 	Title: Chief Executive Officer

 

    	14

    	 

    

 

EXHIBIT A

 

NOTICE OF EXERCISE

 

(To be executed by the Holder of Warrant
if such Holder desires to exercise Warrant)

 

To Corbus Pharmaceuticals Holdings, Inc.:

 

The undersigned hereby
irrevocably elects to exercise this Warrant and to purchase thereunder, ___________________ full shares of Corbus Pharmaceuticals
Holdings, Inc common stock issuable upon exercise of the Warrant and delivery of:

 

(1)         $_________
(in cash as provided for in the foregoing Warrant) and any applicable taxes payable by the undersigned pursuant to such Warrant;
and

 

(2)         __________
shares of Common Stock (pursuant to a Cashless Exercise in accordance with Section 1(b)(ii) of the Warrant) (check here if the
undersigned desires to deliver an unspecified number of shares equal the number sufficient to effect a Cashless Exercise [___]).

 

   The undersigned
requests that certificates for such shares be issued in the name of:

 

 

 

(Please print name, address and social security
or federal employer

identification number (if applicable))

 

 

 

 

 

 

If the shares issuable
upon this exercise of the Warrant are not all of the Warrant Shares which the Holder is entitled to acquire upon the exercise of
the Warrant, the undersigned requests that a new Warrant evidencing the rights not so exercised be issued in the name of and delivered
to:

 

 

 

(Please print name, address and social security
or federal employer

identification number (if applicable))

 

 

 

 

 

 

	 	Name of Holder (print):	 
	 	(Signature):	 
	 	(By:)	 
	 	(Title:)	 
	 	Dated:	 

 

    	15

    	 

    

 

EXHIBIT B

 

FORM OF ASSIGNMENT

 

FOR VALUE RECEIVED,
___________________________________ hereby sells, assigns and transfers to each assignee set forth below all of the rights of the
undersigned under the Warrant (as defined in and evidenced by the attached Warrant) to acquire the number of Warrant Shares set
opposite the name of such assignee below and in and to the foregoing Warrant with respect to said acquisition rights and the shares
issuable upon exercise of the Warrant:

 

	Name of Assignee	Address	Number of Shares
	 	 	 
	 	 	 
	 	 	 
	 	 	 

 

If the total of the
Warrant Shares are not all of the Warrant Shares evidenced by the foregoing Warrant, the undersigned requests that a new Warrant
evidencing the right to acquire the Warrant Shares not so assigned be issued in the name of and delivered to the undersigned.

 

	 	Name of Holder (print):	 
	 	(Signature):	 
	 	(By:)  	 
	 	(Title:) 	 
	 	Dated:

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