Document:

Loan Modification Agreement

 Exhibit 10.1 
 LOAN MODIFICATION AGREEMENT 
 This Loan Modification Agreement is entered into as of June 30, 2008, by
and between ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Borrower”) and SILICON VALLEY BANK (“Bank”). 
 1. DESCRIPTION OF
EXISTING INDEBTEDNESS: Among other indebtedness which may be owing by Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan and Security Agreement, dated on or about December 16, 2005, as may be amended
from time to time, (the “Loan Agreement”). Defined terms used but not otherwise defined herein shall have the same meanings as in the Loan Agreement. 
 Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Indebtedness.” 
 2. DESCRIPTION OF
COLLATERAL. Repayment of the Indebtedness is secured by the Collateral as described in the Loan Agreement. 
 Hereinafter, the above-described security
documents, together with all other documents securing repayment of the Indebtedness shall be referred to as the “Security Documents”. Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Indebtedness shall be referred to as the “Existing Loan Documents”. 
 3. DESCRIPTION OF CHANGE IN TERMS. 
  

	 	A.	Modification to Loan Agreement. 

  

	 	1.	Section 6.2(c) is hereby amended and restated in its entirety to read as follows: 

 (c) At any time Advances are outstanding, within twenty (20) days after the last day of each month, deliver to Bank a duly completed Borrowing Base Certificate signed by a Responsible Officer, with aged listings
of accounts receivable and accounts payable (by invoice date). 
  

	 	2.	Section 6.6 is hereby amended and restated in its entirety to read as follows: 

 6.6 Financial Covenants. Borrower shall maintain, on a consolidated basis with respect to Borrower and its Subsidiaries a ratio (“Adjusted Quick Ratio”) of Quick Assets to Current Liabilities minus
Deferred Revenue and minus the current portion of Subordinated Debt of at least 0.75 to 1.00 as of the last day of each month. 
  

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	 	3.	A new definition of “Borrowing Base” is hereby added to Section 13.1 which shall read as follows: 

 “Borrowing Base” is (a) 80% of Eligible Accounts plus (b) the lesser of 25% of Net Cash or $2,500,000, as determined by Bank
from Borrower’s most recent Borrowing Base Certificate; provided, however, that Bank may decrease the foregoing percentages in its good faith business judgment based on events, conditions, contingencies, or risks which, as
determined by Bank, may adversely affect Collateral. 
  

	 	4.	A new definition of “Eligible Accounts” is hereby added to Section 13.1 which shall read as follows: 

 “Eligible Accounts” are Accounts which arise in the ordinary course of Borrower’s business that meet all Borrower’s
representations and warranties in Section 5.3. Bank reserves the right at any time and from time to time after the Effective Date, to adjust any of the criteria set forth below and to establish new criteria in its good faith business judgment.
Unless Bank agrees otherwise in writing, Eligible Accounts shall not include: 
 (a) Accounts for which the Account Debtor
has not been invoiced; 
 (b) Accounts that the Account Debtor has not paid within ninety (90) days of invoice date;

 (c) Accounts owing from an Account Debtor, fifty percent (50%) or more of whose Accounts have not been paid within
ninety (90) days of invoice date; 
 (d) Credit balances over ninety (90) days from invoice date; 
 (e) Accounts owing from an Account Debtor, including Affiliates, whose total obligations to Borrower exceed forty-five percent
(45%) of all Accounts, for the amounts that exceed that percentage, unless Bank approves in writing; 
 (f) Accounts
owing from an Account Debtor which does not have its principal place of business in the United States; 
 (g) Accounts owing
from an Account Debtor which is a federal, state or local government entity or any department, agency, or instrumentality thereof except for Accounts of the United States if Borrower has assigned its payment rights to Bank and the assignment has
been acknowledged under the Federal Assignment of Claims Act of 1940, as amended; 
  

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 (h) Accounts owing from an Account Debtor to the extent that Borrower is indebted or
obligated in any manner to the Account Debtor (as creditor, lessor, supplier or otherwise—sometimes called “contra” accounts, accounts payable, customer deposits or credit accounts), with the exception of customary credits,
adjustments and/or discounts given to an Account Debtor by Borrower in the ordinary course of its business; 
 (i) Accounts
for demonstration or promotional equipment, or in which goods are consigned, or sold on a “sale guaranteed”, “sale or return”, “sale on approval”, “bill and hold”, or other terms if Account Debtor’s
payment may be conditional; 
 (j) Accounts for which the Account Debtor is Borrower’s Affiliate, officer, employee, or
agent; 
 (k) Accounts in which the Account Debtor disputes liability or makes any claim (but only up to the disputed
or claimed amount), or if the Account Debtor is subject to an Insolvency Proceeding, or becomes insolvent, or goes out of business; 
 (l) Accounts owing from an Account Debtor with respect to which Borrower has received deferred revenue (but only to the extent of such deferred revenue); 
 (m) Accounts for which Bank in its good faith business judgment determines collection to be doubtful; and 
 (n) other Accounts Bank deems ineligible in the exercise of its good faith business judgment. 
  

	 	5.	A new definition of “Net Cash” is hereby added to Section 13.1 which shall read as follows: 

 “Net Cash” means unrestricted cash less the Obligations. 
  

	 	6.	The definition of “Revolving Line” in Section 13.1 is hereby amended and restated in its entirety to read as follows: 

 “Revolving Line” is an Advance or Advances in an aggregate amount outstanding at any time of up to the lesser of (a) $10,000,000
and (b) the Borrowing Base. 
  

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 4. CONSISTENT CHANGES. The Existing Loan Documents are hereby amended wherever necessary to reflect the changes
described above. 
 5. NO DEFENSES OF BORROWER. Borrower agrees that, as of the date hereof, it has no defenses against the obligations to pay any
amounts under the Indebtedness. 
 6. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the existing Indebtedness, Bank is
relying upon Borrower’s representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan Documents remain
unchanged and in full force and effect. Bank’s agreement to modifications to the existing Indebtedness pursuant to this Loan Modification Agreement in no way shall obligate Bank to make any future modifications to the Indebtedness. Nothing in
this Loan Modification Agreement shall constitute a satisfaction of the Indebtedness. 
 7. CONDITIONS. The effectiveness of this Loan Modification
Agreement is conditioned upon the execution and delivery of this Modification Agreement and the receipt by Bank of a loan modification fee in the amount of Ten Thousand Dollars ($10,000). 
 This Loan Modification Agreement is executed as of the date first written above. 
  

									
	BORROWER:	 		 	BANK:
			
	ISTA PHARMACEUTICALS, INC.	 		 	SILICON VALLEY BANK
					
	By:	 	/s/ Vicente Anido, Jr.	 		 	By:	 	/s/ Victor Le
	Name:	 	Vicente Anido, Jr.	 		 	Name:	 	Victor Le
	Title:	 	President and CEO	 		 	Title:	 	Relationship Manager

  

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 EXHIBIT F 
 BORROWING BASE CERTIFICATE 
 Borrower: Ista Pharmaceuticals, Inc. 
 Lender: Silicon Valley Bank 
 Commitment Amount: $10,000,000 
  

				
	 ACCOUNTS RECEIVABLE
	  		
		
	 1. Total Accounts Receivable as of
                    
	  	$	_______________
		
	 2. Less Ineligible Accounts Receivable
	  	$	_______________
		
	 3. TOTAL Eligible Accounts Receivable (#1 minus #2)
	  	$	_______________
		
	 4. Eighty percent (80%) of Eligible Accounts Receivable
	  	$	_______________
		
	 5. Unrestricted Cash and Cash Equivalents as of
                    
	  	$	_______________
		
	 6. Twenty-five percent (25%) Unrestricted Cash and Cash Equivalents
	  	$	_______________
		
	 7. Maximum Loan Amount (#4 plus the lesser of (a) $2,500,000 million and (b) #6)
	  	$	________________
		
	 8. Present balance owing on Line of Credit
	  	$	_______________
		
	 9. LOAN AVAILABILITY (#7 minus #8)
	  	$	_______________

 The undersigned represents and warrants that this is true, complete and correct, and that the information in
this Borrowing Base Certificate complies with the representations and warranties in the Loan and Security Agreement between the undersigned and Silicon Valley Bank. 
  

									
	COMMENTS:	 		 	BANK USE ONLY
					
	By:	 	 	 		 	Received by:	 	 
		 	Authorized Signer	 		 		 	AUTHORIZED SIGNER
		 		 		 	Date:	 	

  

 5Increase Joinder

 Exhibit 10.1 
 INCREASE JOINDER 
 Reference is made to the Revolving Credit and Term Loan Agreement dated as of
July 27, 2007, and amended and restated as of June 12, 2008, (as amended, amended and restated, supplemented or otherwise modified from time to time, the “Credit Agreement”) among ATLAS PIPELINE PARTNERS, L.P., a Delaware
limited partnership (“Borrower”), the Subsidiary Guarantors (such term and each other capitalized term used but not defined herein having the meaning given it in the Credit Agreement), the Lenders, WACHOVIA BANK, NATIONAL
ASSOCIATION, in its capacity as administrative agent for the Lenders (in such capacity, the “Administrative Agent”) and the other agents and arrangers named therein. 
 Upon execution and delivery of this Increase Joinder by the parties hereto as provided in Section 2.12 of the Credit Agreement, the undersigned has
the Commitment set forth in Schedule 1 hereto, effective as of the Closing Date. 
 Borrower hereby represents and warrants that, assuming
the Administrative Agent executes and delivers this Increase Joinder, all of the conditions set forth in Section 2.12(b) of the Credit Agreement with respect hereto have been satisfied and Borrower is in compliance with all of the terms of such
Section. 
 Borrower hereby authorizes the Administrative Agent to take the actions provided in Section 2.12(d) of the Credit Agreement
so that, after giving effect to this Increase Joinder, the Revolver Loans outstanding are held by the Revolver Lenders pro rata based on their Revolver Commitments. 
 The terms and provisions of the Incremental Loans made pursuant to the Incremental Commitments shall be identical to the Revolver Loans issued under the Credit Agreement except as expressly provided in the paragraph
immediately below. 
 Borrower shall have paid all reasonable out-of-pocket costs and expenses of the Administrative Agent in connection with
the preparation, reproduction, execution and delivery of this Increase Joinder (including, without limitation, the reasonable fees and out-of-pocket expenses of counsel for the Administrative Agent with respect thereto) and all other costs, expenses
and fees due under any Loan Document. 
 THIS INCREASE JOINDER SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE
LAWS OF THE STATE OF NEW YORK. 
 This Increase Joinder may be executed by one or more of the parties hereto on any number of separate
counterparts, and all of said counterparts taken together shall be deemed to constitute one and the same instrument. Delivery of an executed signature page hereof by facsimile transmission shall be effective as delivery of a manually executed
counterpart hereof. 

 IN WITNESS WHEREOF, the parties hereto have caused this Increase Joinder to be duly executed and
delivered by their proper and duly authorized officers as of this 27th day of June, 2008. 
  

			
	 Wachovia Bank, N.A.,
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 Bank of America, N.A.,
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 JPMorgan Chase Bank, N.A.,
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 Wells Fargo Bank, N.A.
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 BNP Paribas,
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 Guaranty Ban, FSB,
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 Royal Bank of Canada
as a Lender

		
	By:	 	  

	Name:	 	
	Title:	 	

			
	Accepted and agreed:
	
	ATLAS PIPELINE PARTNERS, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	

			
	 WACHOVIA BANK, NATIONAL ASSOCIATION,
as Administrative Agent

		
	By:	 	  

	Name:	 	
	Title:	 	
		
	By:	 	  

	Name:	 	
	Title:	 	

 Schedule 1 
 COMMITMENTS AND NOTICE ADDRESS 
  

									
	1.	  	Name of Lender:	  	        [            ]	  		  	
		  	Notice Address:	  	        [            ]	  		  	
		  	  
 Attention:
	  	        [            ]	  		  	
		  	Email:	  	        [            ]	  		  	
		  	Telephone:	  	        [            ]	  		  	
		  	Facsimile:	  	        [            ]	  		  	

											
	  
 2.
	  	Additional Revolver Loan Commitment:

			
		
	Wachovia Bank, N.A.	  	$15.0 million
	Bank of America, N.A.	  	$11.0 million
	JPMorgan Chase Bank, N.A.	  	$15.0 million
	Wells Fargo Bank, N.A.	  	$11.0 million
	BNP Paribas	  	$11.0 million
	Guaranty Bank, FSB	  	$ 6.0 million
	Royal Bank of Canada	  	$11.0 million

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