Document:

EX-10.11

 Exhibit 10.11 

VOTING AGREEMENT 
 This
VOTING AGREEMENT (“Agreement”) is made as of September 15, 2013, among Chiesi Farmaceutici S.p.A., an Italian company (“Parent”), Chiesi U.S. Corporation, a Delaware corporation and wholly owned subsidiary of
Parent (“Merger Sub”), Cornerstone Therapeutics Inc, a Delaware corporation (the “Company”) and each of the undersigned stockholders of the Company (each a “Stockholder” and together, the
“Stockholders”). 
 RECITALS: 

WHEREAS, concurrently with the execution and delivery of this Agreement, Parent, Merger Sub and the Company are entering into an Agreement of
Plan of Merger of even date herewith (as the same may be amended from time to time, the “Merger Agreement”), pursuant to which Merger Sub will be merged with and into the Company, and the Company will become a wholly owned
subsidiary of Parent (the “Merger”); 
 WHEREAS, as of the date hereof, each Stockholder is the Beneficial Owner (as
defined below) of Subject Shares (as defined below); and 
 WHEREAS, in order to induce Parent and Merger Sub to enter into the Merger
Agreement, each Stockholder has agreed to enter into this Agreement. 
 NOW, THEREFORE, in consideration of the foregoing premises and of
the covenants and agreements set forth herein and in the Merger Agreement, and intending to be legally bound hereby, the parties agree as follows: 
  

	 	1.	Definitions. 

 (a) “Beneficially Own” or “Beneficial
Owner” with respect to any securities means having “beneficial ownership” as determined pursuant to Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”). 

(b) “Company Capital Stock” means shares of common stock, par value $0.001 per share, of the Company and preferred
stock, par value $0.001 per share, of the Company. 
 (c) “Company Options and Other Rights” means options, warrants
and other rights to acquire, directly or indirectly, shares of Company Capital Stock. 
 (d) “Expiration Date” means
the earlier to occur of (i) the Effective Time (as defined in the Merger Agreement) or (ii) the date on which the Merger Agreement is terminated pursuant to its terms. 

(e) “Subject Shares” means, with respect to each Stockholder, (i) all shares of Company Capital Stock Beneficially
Owned by such Stockholder as of the date of this Agreement; and (ii) all additional shares of Company Capital Stock of which such Stockholder acquires Beneficial Ownership during the period from the date of this Agreement through the Expiration
Date. 

	 	2.	Voting. 

 (a) Each Stockholder hereby agrees that, prior to the Expiration Date, at
any meeting of the stockholders of the Company, however called and at every adjournment and postponement thereof, and in any written action by consent of stockholders of the Company, unless otherwise directed in writing by Parent, such Stockholder
shall cause to be counted as present thereat for purposes of establishing a quorum and shall vote, or cause to be voted, any and all Subject Shares as of the record date of such meeting or written consent: 

(i) in favor of the Merger, the execution and delivery by the Company of the Merger Agreement and the adoption and approval of the
Merger Agreement and the terms thereof, in favor of each of the other actions contemplated by the Merger Agreement and in favor of any action in furtherance of any of the foregoing; 

(ii) against any action or agreement that would result or could reasonably be expected to result in a breach of any representation,
warranty, covenant or obligation of the Company in the Merger Agreement; and 
 (iii) against the following actions (other than the
Merger and the transactions contemplated by the Merger Agreement): (A) any extraordinary corporate transaction, such as a merger, consolidation or other business combination involving the Company or any subsidiary of the Company; (B) any
sale, lease, sublease, license, sublicense or transfer of a material portion of the rights or other assets of the Company or any subsidiary of the Company; (C) any reorganization, recapitalization, dissolution or liquidation of the Company or
any subsidiary of the Company; (D) any change in the individuals who serve as members of the board of directors of the Company; (E) any amendment to the Company’s certificate of incorporation or bylaws; (F) any material change in
the capitalization of the Company or the Company’s corporate structure; and (G) any other action which is intended, or could reasonably be expected, to impede, interfere with, delay, postpone, discourage or adversely affect the Merger or
any of the other transactions contemplated by the Merger Agreement or this Agreement. 
 (b) Prior to the Expiration Date, no
Stockholder shall enter into any agreement or understanding with any Person to vote or give instructions in any manner inconsistent with clause “(i),” clause “(ii)” or clause “(iii)” of this Section 2(a). 

(c) Each Stockholder hereby waives and agrees not to exercise any applicable “appraisal rights” under the Delaware General
Corporation Law with respect to the Subject Shares in connection with the Merger and the Merger Agreement. 
  

	 	3.	Grant of Proxy; Appointment of Proxy. 

 (a) In furtherance of the transactions
contemplated hereby and by the Merger Agreement, and in order to secure the performance by each Stockholder of such Stockholder’s duties under this Agreement, such Stockholder, concurrently with the execution of this

  
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 Agreement, shall execute, in accordance with the provisions of applicable Delaware law, and deliver to Parent an
irrevocable proxy, substantially in the form of Annex A hereto, and irrevocably appoint Parent or its designees, and each of them individually, with full power of substitution and resubstitution, such Stockholder’s attorney-in-fact and proxy to
vote, or, if applicable, to give consent with respect to, all of the Subject Shares as of the record date of such vote or consent in respect of any of the matters set forth in, and in accordance with the provisions of, Section 2(a) (the
“Proxy”). 
 (b) Each Stockholder understands and acknowledges that Parent is entering into the Merger Agreement in
reliance upon such Proxy. Each Stockholder hereby affirms that the Proxy set forth in this Section 3 is given to secure the performance of the duties of such Stockholder under this Agreement. Each Stockholder hereby affirms that the
irrevocable proxy is coupled with an interest and may under no circumstances be revoked prior to the Expiration Date. Each Stockholder hereby ratifies and confirms all that such irrevocable proxy may lawfully do or cause to be done by virtue
hereof. 
 (c) With respect to the Stockholders, the Stockholders and the Company hereby waive, solely with respect to this Agreement,
Section 4.1 of the Company’s 2009 Stockholders Agreement (the “Stockholders’ Agreement”), which Stockholders Agreement shall be terminated in connection with the consummation of the Merger and each Stockholder hereby
revokes any and all prior proxies or powers of attorney given by such Stockholder prior to the date of this Agreement with respect to the voting of the Subject Shares and agrees not to grant any subsequent proxies or powers of attorney on or
following the date of this Agreement with respect to the voting of the Subject Shares until the Expiration Date. 
 (d) Each
Stockholder shall, at such Stockholder’s own expense, perform such further acts and execute such further proxies and other documents and instruments as may reasonably be required to vest in Parent the power to carry out and give effect to the
provisions of this Agreement. 
 4. Covenants of Stockholders. Each Stockholder covenants and agrees for the benefit of Parent
that, until the Expiration Date, such Stockholder will not: 
 (a) sell, transfer, pledge, hypothecate, encumber, assign, tender or
otherwise dispose of, or enter into any contract, option or other arrangement or understanding (whether written or oral) with respect to the sale, transfer, pledge, hypothecation, encumbrance, assignment, tender or other disposition of, (i) any
Subject Shares or any interest therein, or (ii) any Company Options and Other Rights or any interest therein; provided, however, that such Stockholder may convert, exercise or exchange Company Options and Other Rights into or for
shares of Company Capital Stock in which event such shares of Capital Stock shall become and be deemed Subject Shares subject to all the terms and conditions of this Agreement; 

(b) other than the Proxy, grant any powers of attorney or proxies or consents in respect of any of the Subject Shares, deposit any of
such Subject Shares into a voting trust, or enter into a voting agreement with respect to any of such Subject Shares; and 

  
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 (c) take any other action with respect to the Subject Shares that would in any way restrict,
limit or interfere with the performance of such Stockholder’s obligations hereunder or the transactions contemplated hereby and the Merger Agreement. 

5. Representations and Warranties of Stockholders. Each Stockholder represents and warrants to Parent as follows: 

(a) As of the date of this Agreement and at all times through the Expiration Date: 

(i) Such Stockholder is and will be the Beneficial Owner (free and clear of any encumbrances or restrictions) of the outstanding shares
of Company Capital Stock set forth across from the heading “Shares of Company Capital Stock Beneficially Owned” below such Stockholders’ name on the signature page hereof. 

(ii) Such Stockholder is and will be the Beneficial Owner (free and clear of any encumbrances or restrictions) of the outstanding
Company Options and Other Rights set forth across from the heading “Company Options and Other Rights Beneficially Owned” below such Stockholders’ name on the signature page hereof (except to the extent that such Company Options
and Other Rights are converted into, exercised or exchanged for shares of Company Capital Stock); and 
 (iii) Such Stockholder does
not directly or indirectly Beneficially Own any shares of Company Capital Stock or Company Options or Other Rights or other securities of the Company, other than the shares of Company Capital Stock and Company Options and Other Rights set forth
below such Stockholders’ name on the signature page hereof. 
 (b) Such Stockholder has and will have the legal capacity,
power and authority to enter into and perform all of such Stockholder’s obligations under this Agreement and the Proxy. This Agreement has been duly executed and delivered by such Stockholder and, if such Stockholder is a corporation or
partnership, has been duly authorized by all requisite corporate or partnership action of such Stockholder, as the case may be, and upon its execution and delivery by Parent, will constitute a legal, valid and binding obligation of such Stockholder,
enforceable against such Stockholder in accordance with its terms, except as enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws affecting or relating to creditors rights generally, and the
availability of injunctive relief and other equitable remedies. 
 (c) The execution, delivery and performance by such Stockholder of
this Agreement will not (i) conflict with, require a consent, waiver or approval under, or result in a breach of or default under, any of the terms of any contract, commitment or other obligation (written or oral) to which such Stockholder is a
party or by which any of such Stockholder’s assets may be bound, and, if such Stockholder is a corporation or partnership, the organizational documents of such Stockholder, or (ii) violate any order, writ injunction, decree, judgment,
order, statute, rule or regulation applicable to such Stockholder or any of its assets. 

  
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 (d) No filing with, and no permit, authorization, consent or approval of, any state or
federal public body or authority is necessary for the execution of this Agreement by such Stockholder and the consummation by such Stockholder of the transactions contemplated hereby. 

6. Adjustments; Additional Shares. In the event (a) of any stock dividend, stock split, merger, recapitalization,
reclassification, combination, exchange of shares or the like of the capital stock of the Company on, of or affecting the Subject Shares or (b) that a Stockholder shall become the Beneficial Owner of any additional shares of Company Capital
Stock or other securities entitling the holder thereof to vote or give consent with respect to the matters set forth in Section 2(a), then the terms of this Agreement shall apply to the shares of Company Capital Stock or other instruments or
documents held by such Stockholder immediately following the effectiveness of the events described in clause (a) or such Stockholder becoming the Beneficial Owner thereof as described in clause (b), as though, in either case, they were Subject
Shares hereunder. 
 7. Amendments and Waivers. Any provision of this Agreement may be amended or waived if, and only if, such
amendment or waiver is in writing and is signed, in the case of an amendment, by each party to this Agreement, or in the case of a waiver, by the party against whom the waiver is to be effective. No failure or delay by any party in exercising
any right or privilege hereunder shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power or privilege. To the maximum extent
permitted by applicable law, (a) no waiver that may be given by a party shall be applicable except in the specific instance for which it was given and (b) no notice to or demand on one party shall be deemed to be a waiver of any obligation
of such party or the right of the party giving such notice or demand to take further action without notice or demand. 
 8.
Assignment. Neither this Agreement nor any of the rights, interests or obligations hereunder shall be assigned by either party hereto (whether by operation of law or otherwise) without the prior written consent of the other
party. This Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their respective successors and assigns. Any purported assignment not permitted under this Section 8 shall be null and void. 

9. Entire Agreement. This Agreement and the documents, instruments and other agreements specifically referred to herein or
delivered pursuant hereto, set forth the entire understanding of the parties with respect to the subject matter hereof. Any and all previous agreements and understandings between or among the parties regarding the subject matter hereof, whether
written or oral, are superseded by this Agreement. 
 10. Notices. Any notice, request, demand, waiver, consent, approval or
other communication which is required or permitted hereunder shall be in writing and shall be deemed given (a) on the date established by the sender as having been delivered personally; (b) on the date delivered by a private courier as
established by the sender by evidence obtained from the courier; (c) on the date sent by facsimile or electronic mail, with confirmation of transmission, if sent during normal business hours of the recipient, if not, then on the next business
day; or (d) on the fifth day after the date mailed, by certified or registered mail, return receipt requested, postage prepaid. Such communications, to be valid, must be addressed as follows: 

If to Parent or Merger Sub, to: 

Chiesi Farmaceutici S.p.A. 
 Via
Palermo 26/A 
 43122 Parma, Italy 

Attn: Marco Vecchia 
 Facsimile:
+39 0521 774468 

  
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 With a required copy to: 

Morgan, Lewis & Bockius LLP 

101 Park Avenue 
 New York, NY
10178 

	 	Attn:	Steven A. Navarro 

	 	      	Emilio Ragosa 

 Facsimile: (212) 309-6001 

If to Company, to: 
 Cornerstone
Therapeutics Inc. 
 1255 Crescent Green Drive, Suite 250 

Cary, NC 27518 
 Attn: Craig A.
Collard 
 Facsimile: (919) 678-6599 

With a required copy to: 

Clifford Chance LLP 
 51 West
52nd Street 
 New York, NY 10019 

Attn: John Healy 
 Facsimile:
(212) 878-8375 
 If to a Stockholder, to the address set forth below such Stockholder’s name on the signature page hereto.

 or to such other address or to the attention of such person or persons as the recipient party has specified by prior written notice to the sending party
(or in the case of counsel, to such other readily ascertainable business address as such counsel may hereafter maintain). If more than one method for sending notice as set forth above is used, the earliest notice date established as set forth
above shall control. 
 11. Captions. All captions contained in this Agreement are for convenience of reference only, do not
form a part of this Agreement and shall not affect in any way the meaning or interpretation of this Agreement. 

  
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 12. Counterparts. This Agreement may be executed in two or more consecutive
counterparts (including by facsimile, or “.pdf” transmission), each of which shall be deemed to be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument, and shall become effective when one
or more counterparts have been signed by each of the parties and delivered (electronically or otherwise) to the other parties. 
 13.
Severability; Enforcement. Any term or provision of this Agreement which is invalid or unenforceable in any jurisdiction shall, as to that jurisdiction, be ineffective to the sole extent of such invalidity or unenforceability without
rendering invalid or unenforceable the remainder of such term or provision or the remaining terms and provisions of this Agreement in any jurisdiction. If any provision of this Agreement is so broad as to be unenforceable, such provision shall
be interpreted to be only so broad as is enforceable. 
 14. Specific Performance. Stockholder acknowledges that the agreements
contained in this Agreement are an integral part of the transactions contemplated by the Merger Agreement, and that, without these agreements, Parent would not enter into the Merger Agreement, and acknowledges that damages would be an inadequate
remedy for any breach by Stockholder of the provisions of this Agreement. Accordingly, Stockholder agrees that Stockholder’s obligations hereunder shall be specifically enforceable and Stockholder shall not take any action to impede the
other from seeking to enforce such right of specific performance. 
 15. Consent to Jurisdiction. Each of the parties hereto
irrevocably agrees that any legal action or proceeding with respect to this Agreement and the rights and obligations arising hereunder, or for recognition and enforcement of any judgment in respect of this Agreement and the rights and obligations
arising hereunder brought by the other party hereto or its successors or assigns, shall be brought and determined exclusively in the Delaware Court of Chancery, or, if the Delaware Court of Chancery declines to accept jurisdiction over a particular
matter, any federal court within the State of Delaware, or, if both the Delaware Court of Chancery and the federal courts within the State of Delaware decline to accept jurisdiction over a particular matter, any other state court within the State of
Delaware, and, in each case, any appellate court therefrom. Each of the parties hereto hereby irrevocably submits with regard to any such action or proceeding for itself and in respect of its property, generally and unconditionally, to the
personal jurisdiction of the aforesaid courts and agrees that it will not bring any action relating to this Agreement or any of the transactions contemplated by this Agreement in any court other than the aforesaid courts. Each of the parties
hereto hereby irrevocably waives, and agrees not to assert as a defense, counterclaim or otherwise, in any action or proceeding with respect to this Agreement, (i) any claim that it is not personally subject to the jurisdiction of the above
named courts for any reason other than the failure to serve in accordance with this Section 15, (ii) any claim that it or its property is exempt or immune from the jurisdiction of any such court or from any legal process commenced in such
courts (whether through service of notice, attachment prior to judgment, attachment in aid of execution of judgment, execution of judgment or otherwise) and (iii) to the fullest extent permitted by the applicable law, any claim that
(x) the suit, action or proceeding in such court is brought in an inconvenient forum, (y) the venue of such suit, action or proceeding is improper or (z) this Agreement, or the subject matter hereof, may not be enforced in or by such
courts. Each of the parties hereto agrees that service of process upon such party in any such action or proceeding shall be effective if such process is given as a notice in accordance with Section 10. EACH OF THE PARTIES TO THIS
AGREEMENT HEREBY 

  
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IRREVOCABLY WAIVES TO THE EXTENT PERMITTED BY APPLICABLE LAW ANY AND ALL RIGHT TO A TRIAL BY JURY IN ANY DIRECT OR INDIRECT ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF OR RELATING TO THIS
AGREEMENT, THE TRANSACTIONS CONTEMPLATED HEREIN. EACH PARTY (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF
LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (B) MAKES THIS WAIVER VOLUNTARILY, AND (C) ACKNOWLEDGES THAT EACH PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS CONTAINED IN THIS
SECTION 15. 
 16. Governing Law. This Agreement and all claims or causes of action (whether in tort, contract or
otherwise) that may be based upon, arise out of or relate to this Agreement or the negotiation, execution or performance of this Agreement (including any claim or cause of action based upon, arising out of or related to any representation or
warranty made in or in connection with this Agreement) shall be governed by and construed in accordance with the laws of the State of Delaware, without giving effect to any choice or conflict of law provision or rule (whether of the State of
Delaware or any other jurisdiction) that would cause the application of the laws of any jurisdiction other than the State of Delaware. 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, this Agreement has been duly executed by the parties hereto all as of the day
and year first above written. 
  

			
	 CHIESI FARMACEUTICI S.P.A.

		
	 By:
	 	 /s/ Giacomo Chiesi

	 Name:
	 	Giacomo Chiesi
	 Title:
	 	Director and Business Development Manager
	
	 CHIESI U.S. CORPORATION

		
	 By:
	 	 /s/ Danilo Piroli

	 Name:
	 	Danilo Piroli
	 Title:
	 	Vice President
	
	 CORNERSTONE THERAPEUTICS INC.

		
	 By:
	 	 /s/ Craig A. Collard

	 Name:
	 	Craig A. Collard
	 Title:
	 	Chief Executive Officer

 [Signature Page to Voting Agreement] 

 
	
	 STOCKHOLDER

	
	 /s/ Craig A. Collard

	 Craig A. Collard

  

			
	 Address
	  	
		
	 Shares of Company Capital Stock Beneficially Owned:
	  	1,612,225
	 Company Options and Other Rights Beneficially Owned:
	  	725,699

  

			
	STOCKHOLDER
	
	CORNERSTONE BIOPHARMA HOLDINGS, LTD.
		
	By:	 	 /s/ Craig A. Collard

	 Name:
	 	Craig A. Collard
	 Title:
	 	President and Chief Executive Officer

  

			
	 Address
	  	
		
	 Shares of Company Capital Stock Beneficially Owned:
	  	1,567,225
	 Company Options and Other Rights Beneficially Owned:
	  	0

 [Signature Page to Voting Agreement] 

 ANNEX A 

IRREVOCABLE PROXY 

Capitalized terms used but not defined herein shall have the meaning ascribed to such terms in the Voting Agreement, dated as of
September 15, 2013, among Chiesi Farmaceutici S.p.A., an Italian company (“Parent”), Chiesi U.S. Corporation, a Delaware corporation and wholly owned subsidiary of Parent (“Merger Sub”), Cornerstone
Therapeutics Inc, a Delaware corporation (the “Company”) and each of the stockholders of the Company signatory thereto (each a “Stockholder” and together, the “Stockholders”) (the “Voting
Agreement”). A copy of the Voting Agreement is attached hereto and is incorporated by reference herein. 
 This Proxy is given
to secure the performance of the duties of the undersigned Stockholder pursuant to the Voting Agreement and is granted in consideration of Parent entering into the Merger Agreement. 

The undersigned Stockholder hereby irrevocably appoints Parent and Merger Sub, and each of them individually, the sole and exclusive
attorneys-in-fact, agents and proxies, with full power of substitution and resubstitution in each of them, for the undersigned Stockholder and in the name, place and stead of the undersigned Stockholder, to vote or, if applicable, to give written
consent, with respect to, all Subject Shares and which the undersigned Stockholder is or may be entitled to vote at any meeting of the Company held after the date hereof, whether annual or special and whether or not an adjourned meeting, or, if
applicable, to give written consent with respect thereto, in accordance with the provisions of Section 2(a) of the Voting Agreement as follows: 

(i) in favor of the Merger, the execution and delivery by the Company of the Merger Agreement and the adoption and
approval of the Merger Agreement and the terms thereof, in favor of each of the other actions contemplated by the Merger Agreement and in favor of any action in furtherance of any of the foregoing; 

(ii) against any action or agreement that would result in a breach of any representation, warranty, covenant or obligation
of the Company in the Merger Agreement; and 
 (iii) against the following actions (other than the Merger and the
transactions contemplated by the Merger Agreement): (A) any extraordinary corporate transaction, such as a merger, consolidation or other business combination involving the Company or any subsidiary of the Company; (B) any sale, lease,
sublease, license, sublicense or transfer of a material portion of the rights or other assets of the Company or any subsidiary of the Company; (C) any reorganization, recapitalization, dissolution or liquidation of the Company or any subsidiary
of the Company; (D) any change in the individuals who serve as members of the board of directors of the Company; (E) any amendment to the Company’s certificate of incorporation or bylaws; (F) any material change in the
capitalization of the Company or the Company’s corporate structure; and (G) any other action which is intended, or could reasonably be expected, to impede, interfere with, delay, postpone, discourage or adversely affect the Merger or any
of the other transactions contemplated by the Merger Agreement or this Agreement. 

 This Proxy is coupled with an interest, shall be irrevocable to the fullest extent permitted by
law and shall be binding on any successor in interest of the undersigned Stockholder. This Proxy shall not be terminated by operation of law upon the occurrence of any event, including, without limitation, the death or incapacity of the undersigned
Stockholder. 
 This Proxy shall operate to revoke any prior proxy as to the Subject Shares heretofore granted by the undersigned
Stockholder with respect to the subject matter of the Voting Agreement and the Merger Agreement. 
 This Proxy shall terminate on the
Expiration Date. 
 SIGNATURE TO IRREVOCABLE PROXY 

 

	
	 STOCKHOLDER

	
	 /s/ Craig A. Collard

	 Craig A. Collard

	
	 Date: 9/15/13

 ANNEX A 

IRREVOCABLE PROXY 

Capitalized terms used but not defined herein shall have the meaning ascribed to such terms in the Voting Agreement, dated as of
September 15, 2013, among Chiesi Farmaceutici S.p.A., an Italian company (“Parent”), Chiesi U.S. Corporation, a Delaware corporation and wholly owned subsidiary of Parent (“Merger Sub”), Cornerstone
Therapeutics Inc, a Delaware corporation (the “Company”) and each of the stockholders of the Company signatory thereto (each a “Stockholder” and together, the “Stockholders”) (the “Voting
Agreement”). A copy of the Voting Agreement is attached hereto and is incorporated by reference herein. 
 This Proxy is given
to secure the performance of the duties of the undersigned Stockholder pursuant to the Voting Agreement and is granted in consideration of Parent entering into the Merger Agreement. 

The undersigned Stockholder hereby irrevocably appoints Parent and Merger Sub, and each of them individually, the sole and exclusive
attorneys-in-fact, agents and proxies, with full power of substitution and resubstitution in each of them, for the undersigned Stockholder and in the name, place and stead of the undersigned Stockholder, to vote or, if applicable, to give written
consent, with respect to, all Subject Shares and which the undersigned Stockholder is or may be entitled to vote at any meeting of the Company held after the date hereof, whether annual or special and whether or not an adjourned meeting, or, if
applicable, to give written consent with respect thereto, in accordance with the provisions of Section 2(a) of the Voting Agreement as follows: 

(i) in favor of the Merger, the execution and delivery by the Company of the Merger Agreement and the adoption and
approval of the Merger Agreement and the terms thereof, in favor of each of the other actions contemplated by the Merger Agreement and in favor of any action in furtherance of any of the foregoing; 

(ii) against any action or agreement that would result in a breach of any representation, warranty, covenant or obligation
of the Company in the Merger Agreement; and 
 (iii) against the following actions (other than the Merger and the
transactions contemplated by the Merger Agreement): (A) any extraordinary corporate transaction, such as a merger, consolidation or other business combination involving the Company or any subsidiary of the Company; (B) any sale, lease,
sublease, license, sublicense or transfer of a material portion of the rights or other assets of the Company or any subsidiary of the Company; (C) any reorganization, recapitalization, dissolution or liquidation of the Company or any subsidiary
of the Company; (D) any change in the individuals who serve as members of the board of directors of the Company; (E) any amendment to the Company’s certificate of incorporation or bylaws; (F) any material change in the
capitalization of the Company or the Company’s corporate structure; and (G) any other action which is intended, or could reasonably be expected, to impede, interfere with, delay, postpone, discourage or adversely affect the Merger or any
of the other transactions contemplated by the Merger Agreement or this Agreement. 

 This Proxy is coupled with an interest, shall be irrevocable to the fullest extent permitted by
law and shall be binding on any successor in interest of the undersigned Stockholder. This Proxy shall not be terminated by operation of law upon the occurrence of any event, including, without limitation, the death or incapacity of the undersigned
Stockholder. 
 This Proxy shall operate to revoke any prior proxy as to the Subject Shares heretofore granted by the undersigned
Stockholder with respect to the subject matter of the Voting Agreement and the Merger Agreement. 
 This Proxy shall terminate on the
Expiration Date. 
 SIGNATURE TO IRREVOCABLE PROXY 

 

			
	 STOCKHOLDER

	
	 CORNERSTONE BIOPHARMA HOLDINGS, LTD.

		
	 By:
	 	 /s/ Craig A. Collard

	 Name:
	 	Craig A. Collard
	 Title:
	 	President and Chief Executive Officer
	
	 Date: 9/15/13EX-10.18

 EXHIBIT 10.18 

JOINT FILING AGREEMENT 
 Each of the undersigned
hereby agrees and consents that the Schedule 13D/A filed herewith (the “Schedule 13D/A”) by Cornerstone Biopharma Holdings, Ltd. is filed on behalf of each of them pursuant to the authorization of the undersigned to make such filing
and that such Schedule 13D/A is filed jointly on behalf of each of them, pursuant to Sections 13(d) and 13(g) of the Securities Exchange Act of 1934, as amended, and the rules promulgated thereunder, including Rule 13d-1(k)(1). Each of the
undersigned hereby agrees that such Schedule 13D/A is, and any further amendments to the Schedule 13D/A will be, filed on behalf of each of the undersigned. Each of the persons is not responsible for the completeness or accuracy of the information
concerning the other persons making this filing unless such person knows or has reason to believe that such information is inaccurate. This agreement may be signed in counterparts. This agreement is effective as of September 20, 2013. 

 

									
		 		 		 	CORNERSTONE BIOPHARMA HOLDINGS, LTD.
				
	Dated: September 20, 2013	 		 		 	
				
		 		 		 	 /s/ Craig A. Collard

		 		 		 	Name:	 	Craig A. Collard
		 		 		 	Title:	 	President and Chief Executive Officer
				
		 		 		 	 /s/ Craig A. Collard

		 		 		 	Craig A. Collard

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