Document:

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                                                                    CONFIDENTIAL

                       SUBLEASE ASSIGNMENT AND ASSUMPTION
                                    AGREEMENT

         This SUBLEASE ASSIGNMENT AND ASSUMPTION AGREEMENT (the "Agreement'), is
entered into this -- day of August, 1998. by and among Communications World of
Seattle North, a Washington corporation ("Assignor'); Rosetta Inpharmatics, a
Delaware corporation ("Assignee"); Siemens Medical Systems, a Delaware
corporation ("Sublandlord'); and Communications World International, a Colorado
corporation ("CWI').

                                   I. RECITALS

         A. Assignor is the sublessee under that certain Sublease Agreement,
dated March 14th, 1997, with Sublandlord, a copy of which is attached hereto as
EXHIBIT A (the "Sublease").

         B. Assignor desires to assign all of its beneficial right, title and
interest in the Sublease to Assignee according to the terms specified below.
Sublandlord is willing to consent to such assignment, subject to the terms and
conditions of this Agreement including, but not limited to, the guarantee by
CWI, the parent corporation of Assignor, pursuant to Section 6 of this
Agreement.
                                  II. AGREEMENT

         Now, therefore, in consideration of the above recitals, and other
valuable consideration the receipt of which is acknowledged, the parties agree
as follows:

1.       CONFIRMATION OF SUBLEASE.

         Sublandlord and Assignor hereby acknowledge and confirm the existence,
validity and enforceability of the Sublease.

2.       ASSIGNMENT.

         Assignor assigns to Assignee all of its beneficial right, title and
interest in the Sublease according to the terms specified therein (the
"Assignment"). The effective date of the Assignment shall be August 15, 1998
(the "Effective Date").

3.       CONTINUING LIABILITY.

         Notwithstanding Sublandlord's approval to the Assignment, Assignor
recognizes and agrees that Assignor shall remain jointly and severally liable
with Assignee on all obligations imposed under the Sublease until the Sublease
Expiration Date, and that in the event of a default under the Sublease by
Assignee, Sublandlord may bring a separate action or actions against Assignor
whether or not Assignee is joined in such action or actions, and Assignor waives
any

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right to require Sublandlord to proceed against Assignee or any other party or
person (including a guarantor), or proceed against or exhaust any security held
from any party or person (including a guarantor) under the Sublease, or proceed
against or exhaust any other remedy in Sublandlord's power.

4.       ASSUMPTION OF SUBLEASE.

         (a) From and after the Effective Date, Assignee assumes all of
Assignor's obligations under the Sublease, and agrees to fully and faithfully
perform every covenant and condition thereunder. All terms of the Sublease shall
remain in full force and effect, provided, however, nothing herein shall
preclude Sublandlord from agreeing to further modifications, extensions or
renewals of the Sublease. Any modifications to the Sublease prior to the
Sublease Expiration Date shall not affect the joint and several liability of
Assignor.

         (b) Assignee has inspected the Premises and accepts them "as is." Any
further modifications or tenant improvements shall be at Assignee's sole
expense, and shall be performed in accordance with the Sublease.

5.       SUBLANDLORD'S CONSENT TO ASSIGNMENT.

         Subject to the terms of this Agreement, Sublandlord consents to the
Assignment, provided that Assignor pays any fees imposed by Landlord under the
Main Lease (defined below) in connection with Landlord's consent to the
Assignment.

6.       GUARANTEE OF SUBLEASE.

         (a) Notwithstanding the Assignment, CWI unconditionally guarantees (the
"Guarantee") the full performance of each and every term, covenant and condition
of the Sublease to be kept and performed by Tenant under the Sublease (the
`Subtenant'), including but not limited to the payment of all rentals and other
charges to accrue thereunder, during the term of the Sublease.

         (b) The Guarantee shall continue in favor of the Sublandlord during the
term of the Sublease, unchanged by any bankruptcy, reorganization or insolvency
of Subtenant! Assignor, Assignee, or any successor or assignee thereof or by any
disaffirmance or abandonment by a trustee of any subtenant. No extension,
modification, alteration or assignment of the Main Lease shall in any manner
release or discharge CWI. Sublandlord shall provide CWI with written notice of
any such extension, modification, alteration, or assignment. CWI's obligations
and undertakings under this Guaranty shall remain in full force and effect and
shall survive the expiration or earlier termination of the Sublease.

         (c) Sublandlord, without notice, may assign this Guarantee in whole or
in part and no assignment or transfer of the Sublease by Sublandlord shall
operate to extinguish or diminish the liability or obligations of CWI under this
Section 6.

                                       -2-
<PAGE>

         (d) The liability and obligations of CWI under this Guarantee shall be
primary in any right of action which shall accrue to Sublandlord under the
Sublease. Sublandlord, at its option, may proceed against CWI without having
commenced any action or having obtained any judgment or otherwise proceeded
against Assingor, Assignee, or other Subtenant.

         (e) CWI shall pay Sublandlord's reasonable attorneys' fees and all
costs and other expenses incurred in any collection or attempted collection or
in any negotiations relating to the obligations guaranteed by this Section 6 or
enforcing this Guarantee against CWI.

         (f) CWI shall and does hereby waive notice of any demand by
Sublandlord, as well as any notice of default in the payment of rent or any
other amounts payable by Subtenant under the provisions of the Sublease, or
notice of any other default by Subtenant under the Sublease.

7.       DEFINED TERMS.

         Except as otherwise indicated, all, defined terms used in this
Agreement shall have the same meaning as those defined terms used in the
Sublease.

8.       AGENCY DISCLOSURE AND COMMISSION AGREEMENT.

         Trammell Crow Company represents Assignor. David Alexander Co.
represents Assignee. Assignor shall pay a real estate brokerage commission of
$12,945.75 to Trammell Crow Company. Commissions shall be payable on mutual
execution of this Agreement. Assignor and Assignee each warrant to the other
that they have not had dealings in connection with this transaction with any
other broker or agent, and shall indemnify and defend each other from and
against any claimsor liability arising out of or In connection with any breach
of the foregoing warranty.

9.       CORPORATE AUTHORITY.

         Each individual executing this Assignment on behalf of Assignor and
Assignee represents and warrants that he/she is duly authorized to execute and
deliver this Assignment on behalf of the named corporation, in accordance with a
duly adopted resolution of the Board of Directors of Assignor and Assignee, and
in accordance with the bylaws of Assignor and Assignee, and that this Assignment
is binding upon Assignor and Assignee. Upon Sublandlord's request, Assignor and
Assignee shall, within thirty (30) days after execution of this Assignment,
deliver to Sublandlord a certified copy of a resolution of the Board of
Directors of Assignor and Assignee ,respectively, authorizing or ratifying the
execution of this Assignment.

10.      SUCCESSORS AND ASSIGNS.

         The terms and conditions of this Agreement shall be binding upon and
inure to the benefit of the respective successors and assigns of the parties to
this Agreement.

                                       -3-
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ASSIGNOR:                                             ASSIGNEE:

Communication World of Seattle North         Rosetta Inpharmatics
------------------------------------         --------------------
a Washington corporation                     a Delaware corporation

By: /s/: Scott E. Harris                     By: /s/: John J. King II
    ------------------------                    -------------------------------
Name: Scott E. Harris                        Name: John J. King II
      ----------------------                       ----------------------------
Its: Treasurer                               Its: Sr. Vice President
     -----------------------                      -----------------------------
Date: 8-10-98                                Date: 8-6-98
      ----------------------                       ----------------------------

SUBLANDLORD:                                 CWI:

Siemens Medical Systems Inc.                 Communications World International
----------------------------                 ----------------------------------
a Delaware corporation                       a Colorado corporation

By: /s/: Peter H. Kroener                    By: /s/: Scott E. Harris
   -------------------------                    -------------------------------
Name: Peter H. Kroener                       Name: Scott E. Harris
      ----------------------                       ----------------------------
Its: VP - Finance                            Its: EVP/CFO
     -----------------------                      -----------------------------
Date: 8-14-98                                Date: 8-10-98
      ----------------------                       ----------------------------

                                      -4-
<PAGE>

                            CONSENT OF MAIN LANDLORD

         Riggs & Company, a division of Riggs Bank NA., formerly known as The
Riggs National Bank of Washington, D.C., as Trustee of the Multi-Employer
Property Trust, the Landlord ("Landlord") under that certain Lease Agreement
dated June 1, 1995, as amended, by and between Landlord and Siemens Medical
Systems, Inc., as Tenant (the "Main Lease"), hereby consents to the assignment
of the Sublease, and additionally agrees and acknowledges that

         (a) Landlord reserves the right to collect up to two hundred fifty
dollars ($250.00) of the processing and leasing fee pursuant to Paragraph 12(A)
of the Main Lease in connection with the Assignment, provided that all other
portions of Section 12(A) shall remain in force and effect; and

         (b) As of the date of this Agreement, to Landlord's actual knowledge,
which for purposes of this Agreement means to the actual knowledge of Peter
Crolius, without duty of further investigation, there are no defaults on the
part of Landlord or Tenant under the Main Lease, as of the date hereof.

RIGGS & COMPANY. A DIVISION OF RIGGS BANK N.A.,
FORMERLY KNOWN AS THE RIGGS NATIONAL BANK OF WASHINGTON. D.C.,
AS TRUSTEE OF THE MULTIEMPLOYER PROPERTY TRUST,

By:
   --------------------------------------------------

Name:
     ------------------------------------------------

Its:
    -------------------------------------------------

Date:
     ----------------------------------

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STATE OF COLORADO       )
------------------------
                        ) ss Englewood
COUNTY OF ARAPAHUE      )
------------------------

         I certify that I know or have satisfactory evidence that SCOTT E.
HARRIS is the person who appeared before me, and said person acknowledged that
he/she signed this instrument, on oath stated that he/she was authorized to
execute the instrument and acknowledged it as the TREASURER of COMMUNICATIONS
WORLD OF NORTH SEATTLE, a Washington corporation, to be the free and voluntary
act of such party for the uses and purposes mentioned in the instrument.

         Dated: 8/10/98
                -------

         NOTARY SEAL
                                      /s/ Angela M. Westback
                                      --------------------------------------

                                      Notary Public
                                      --------------------------------------
                                      Title
                                      My Commission expires: 4/18/2001
                                                             ---------------

STATE OF WASHINGTON     )
------------------------
                        ) ss.
COUNTY OF KING          )
------------------------

         I certify that I know or have satisfactory evidence that :JOHN J. KING,
II is the person who appeared before me, and said person acknowledged that he
signed this instrument, on oath stated that he was authorized to execute the
instrument and acknowledged it as the SR. VICE PRESIDENT of ROSETTA
INPHARMATICS, a Delaware corporation, to be the free and voluntary act of such
party for the uses and purposes mentioned in the instrument.

         Dated: 8/6/98
                ------

         NOTARY SEAL
                                      /s/ Edward M. Yoshida
                                      --------------------------------------

                                      Notary Public
                                      --------------------------------------
                                      Title
                                      My Commission expires: 5/20/1999
                                                             ---------------

                                      -6-
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                                    EXHIBIT A

                                    SUBLEASE

                                      -7-
<PAGE>

                              AMENDMENT OF SUBLEASE

         THIS AGREEMENT (the "Amendment") made as of the -- day of August, 1998,
between Siemens Medical Systems, Inc., a Delaware corporation, having an address
at 186 Wood Avenue South, Iselin, NJ 08830 (the "Landlord") and Rosetta
Inpharmatics, a Delaware corporation, having an office at
________________________________________________,(the "Subtenant").

                                   WITNESSETH:

         WHEREAS, by Sublease Agreement (as amended, the "Sublease"), dated
March 14, 1997, between Sublandlord and Communications World of Seattle North
("CWSN"). Tenant, Landlord did demise and let unto CWSN and CWSN did hire and
take from Sublandlord, the premises described in the Sublease (the "Demised
Premises") and

         WHEREAS, CWSN assigned its interest in and to the Sublease to Subtenant
and Subtenant did accept such assignment and assume all of the obligations of
CWSN in and to the Sublease pursuant to that certain Sublease Assignment and
Assumption Agreement, dated as of August___' 1998: and

         WHEREAS, Sublandlord and Subtenant desire to modify, amend and
supplement the Lease on the terms, covenants and conditions more particularly
set forth herein.

         NOW, THEREFORE, in consideration of the sum of Ten Dollars ($10.00)
paid by Tenant to Landlord and for other good and valuable consideration, the
mutual receipt and legal sufficiency of which are hereby acknowledged, the
parties hereto agree as follows:

                                      -8-
<PAGE>

         Section 23 of the Sublease is hereby amended to increase the amount
being held as security under the Sublease to $8,456.00.*

         Except as expressly modified, amended and supplemented by this
Amendment, all of the terms, covenants and conditions of the Sublease shall
remain in full force and effect. All defined terms used herein shall have the
meanings ascribed to such terms in the Sublease, unless specifically defined
herein.

          IN WITNESS WHEREOF, the parties hereto have caused this Amendment to
be executed as of the day and year first above written.

                                      SIEMENS MEDICAL SYSTEMS, INC.,
                                      Sublandlord

                                      By:
                                         -----------------------------------
                                      Name:
                                      Title:

                                      By: /s/ Peter H. Kroener
                                         -----------------------------------
                                      Name: VP - Finance
                                      Title: P.H. Kroener

                                      ROSETTA INPHARMATICS

                                      By:
                                         -----------------------------------
                                      Name:
                                      Title:

* of which $4,228.00 is the sum previously paid by CWSN and $4,228.00 is the
amount to be paid by Subtenant.

                                      -9-
<PAGE>

                                    SUBLEASE

         SUBLEASE made as of the 14 day of March, 1997 between SIEMENS MEDICAL
SYSTEMS, INC., a Delaware corporation having an office at 186 Wood Avenue South,
Iselin, New Jersey 08830 (the "Landlord"), and COMMUNICATIONS WORLD OF SEATTLE,
INC., a Washington corporation, having an office at Kirkland 405 Corporate
Center, Building H, 12004-115th Avenue NE, Kirkland, Washington 98034 (the
"Tenant").

                                   WITNESSETH:

Landlord and Tenant agree as follows:

         1. SUBLEASING. Subject to all the terms, covenants, conditions and
provisions of that certain Lease (as amended by the First Amendment, hereinafter
referred to as the "Main Lease"), dated June 1, 1995, between The Riggs National
Bank of Washington, D.C. as Trustee of the Multi-Employer Property Trust, as
landlord (hereinafter referred to as the "Main Landlord"), and Siemens Medical
Systems, Inc., as tenant, and that certain First Amendment to Lease (the "First
Amendment"), dated as of October23, 1995, copies of which are attached hereto as
Exhibit A, Tenant hereby hires and takes from Landlord that space (hereinafter
referred to as the "Subleased Premises") in the building known as 12004 115th
Avenue NE, Kirkland, Washington 98034 (the "Building"), shown indicated by
crosshatching on the floor plan contained in Exhibit B attached hereto.

         2. COMMENCEMENT AND TERMINATION DATE. The Subleased Premises are
demised for a term commencing on the later to occur of (I) April 12, 1997 and
(ii) the date the Main Landlord consents to this Sublease pursuant to Article 22
hereof (the "Sublease Commencement Date"), and expiring on July 31, 2001 (the
"Expiration Date"), provided, however, Landlord shall have

                                      -10-
<PAGE>

the right to delay the Sublease Commencement Date, in the event that Landlord
will not be able to vacate the Subleased Premises by-April 11, 1997.

         3. RENT. (a) Tenant shall pay rent to Landlord for the Subleased
Premises (I) from the Sublease Commencement Date until July 31, 1998 at the
annual rate of Fifty Thousand Seven Hundred Thirty Six and 00/100 Dollars
($50,736.00), payable in advance In equal monthly installments of Four Thousand
Two Hundred Twenty Eight and 00/100 Dollars ($4,228.00) on the first day of each
calendar month during the term of this Sublease, and (ii) from August 1, 1998
until the Expiration Date, at the annual rate of Fifty Six Thousand Eight
Hundred Thirty Two and 00/1 00 Dollars ($56,832.00), payable in advance in equal
monthly installments of Four Thousand Seven Hundred Thirty Six and 00/100
Dollars ($4,736.00) on the first day of each calendar month during the term of
this Sublease, except that (i) rent for any portion of a calendar month at the
beginning or end of the term shall be apportioned,. and paid on the date of
commencement of the term, or the first day of the calendar month in which the
term expires, as the case may be, and (ii) Tenant shall pay upon execution and
delivery of this Sublease, the first full installment of rent payable hereunder,
to be applied against the first payments of rent due hereunder. Such rent shall
be in addition to all other sums payable hereunder, which other sums shall
constitute additional rent. All rent shall be paid at the office of Landlord or
such other place as Landlord may designate, without any prior demand or notice
therefor, or any setoff or deduction whatsoever.

         (b) Tenant shall additionally pay additional rent to the Landlord for
the Subleased Premises in' a monthly amount equal to all charges pursuant to the
Main Lease for real estate taxes, operating expenses and other items of
additional rent. Such amounts shall be paid not later than ten (10) days after
demand therefor.

                                      -11-
<PAGE>

         (c) Notwithstanding the foregoing, provided that Tenant is not then in
default, beyond applicable notice and grace periods, of any of the terms,
conditions or covenants of this Sublease, Landlord hereby waives the right to
collect the amount of Two Thousand One Hundred Fourteen and 001100 Dollars
($2,114.00) out of the first full monthly payment of rent payable pursuant to
Article 3(a).

         (d) Tenant shall pay all commercial rent or occupancy taxes imposed in
connection with this Sublease or the payment of rent or additional rent
hereunder.

         4. RIGHTS AND OBLIGATIONS OF TENANT. Tenant shall conform to, and use
the Subleased Premises in accordance with, all the terms, covenants and
conditions of the Main Lease, and Will do no act which will result in a
violation of such terms, covenants and conditions. Tenant acknowledges that this
Sublease is subject and subordinate to the terms and conditions of the Main
Lease. Tenant shall perform all of the terms, covenants and conditions of the
Main Lease on the part of the tenant therein named to be performed (except that
the payment of the Monthly Base Rent (as such term is defined in the Main Lease)
provided for in the Main Lease shall be the obligation of the Landlord) Insofar
as such terms, covenants and conditions relate to the Subleased Premises.

         Except as specifically provided to the contrary herein, all of the
terms and conditions of the Main Lease shall apply to govern the obligations and
rights of the parties hereunder and the landlord-tenant relationship created
hereby as if all of such terms and conditions had been restated in their
entirety in this Sublease except that all references therein to "Tenant" shall
mean Tenant (as defined herein) and all references therein to "Landlord" shall
mean Landlord (as defined herein). Without limiting the generality of the
foregoing, Tenant shall be entitled to the rights of Landlord, as tenant under
the Main Lease, insofar as the same relate to the Subleased

                                      -12-
<PAGE>

Premises. Landlord and Tenant agree, however, that Tenant shall have no rights
with respect to the matters set forth in Paragraphs 6, 11, 13(A), 22 and 24 of
the Main Lease and Addendum to Paragraph IC, Addendum to 5A, Additional
Paragraph 28, Additional Paragraph 31(B) and the second sentence of Paragraph
31(D) and Additional Paragraph 33 of the Main Lease and in Paragraphs 2 and 3 of
the First Amendment. Landlord shall have no liability by reason of any default
of the Main Landlord, it being understood that if Landlord shall fail to fulfill
any obligation of the Landlord hereunder and if such failure is caused by the
failure of the Main Landlord to comply with Its obligations under the Main
Lease, then Landlord shall have no obligation or liability by reason of such
failure, but in such event Tenant shall be subrogated to the rights of Landlord
to enforce the obligations of the Main Landlord insofar as such obligations
relate to the Subleased Premises. Without limiting the generality of the
foregoing, Tenant understands that the supplying of water, electricity and other
utilities, window-washing and building maintenance and repair are the
obligations of the Main Landlord as set forth in the Main Lease, and that
Landlord has no control thereof, and assumes no responsibility in connection
therewith, and shall not be liable in any way with respect to the failure of or
interference with any of such services.

         Tenant shall neither do nor permit anything to be done which would
cause the Main Lease to be terminated or forfeited by reason of any right of
termination or forfeiture reserved or vested In the Main Landlord under the Main
Lease. Tenant shall Indemnify, defend and hold Landlord harmless from and
against all loss, cost, liability and expense (including, without limitation,
attorney's fees and. disbursements) incurred by Landlord in connection with any
and all actions or claims arising in connection with any breach or default, or
claimed breath or

                                      -13-
<PAGE>

default, of the Main Lease or in connection With any act or omission of Tenant,
its agents, employees, contractors and invitees in, about or relating to the
Subleased Premises.

         5. USE. Tenant shall use the Subleased Premises solely for those
purposes permitted pursuant to of the Main Lease and for no other purpose.
Tenant shall not use the Subleased Premises for any purpose Which is prohibited
under the Main Lease.

         6. ALTERATIONS. Tenant shall not make any alterations in or to the
Subleased Premises without the prior written consent of Landlord. Any such
changes shall be made in compliance with the Main Lease (including, without
limitation, the requirement to obtain the Main Landlord's consent for certain
types of alterations and the obligation to restore the Subleased Premises upon
the expiration of this Sublease).

         7. NO ASSIGNMENT OR SUBLETTING. Tenant may not assign this Sublease,
nor further sublet the Subleased Premises, nor permit the same to be occupied by
others, without the prior written consent of Landlord in each instance. A
transfer of control of Tenant, including, without being limited to, a transfer
of stock or partnership Interest or the merger, consolidation, sale of all or
substantially all of the other assets of Tenant or other corporate or other
reorganization of Tenant (whether or not Tenant shall be the surviving entity),
shall be deemed an assignment under this Lease and shall be subject to all the
provisions of this Article, including the requirement of obtaining Landlord's
prior consent. The consent by Landlord to any assignment, mortgage, pledge,
encumbrance, transfer or subletting shall not constitute a waiver of the
necessity for such consent to any subsequent assignment, mortgage, pledge,
encumbrance, transfer or subletting. As provided in Article 4 hereof any such
proposed assignment or further subletting shall be subject to the restrictions
regarding assignment and subletting contained in the Main Lease and the rights
of the Main Landlord thereunder.

                                      -14-
<PAGE>

         8. DEFAULT. The provisions of Articles 18 and 19 of the Main Lease
shall apply to any default by Tenant hereunder.

         9. INTENTIONALLY DELETED.

         10. [INTENTIONALLY DELETED.]

         11. OVERTIME SERVICES. If Tenant shall request freight elevator
facilities, heat, cooled air or mechanical ventilation or any other service for
which a charge is imposed pursuant to the Main Lease or otherwise, Tenant shall
either (i) if the Main Landlord bills the Tenant directly for such services, pay
the full amount of such charge to the Main Landlord within five (5) days after
demand, or (ii) If the Main Landlord bills the Landlord for such services, pay
the full amount of such charge to Landlord within five (5) days after demand.
Landlord and Tenant shall endeavor to have the Main Landlord forward copies of
invoices for all such services directly to Tenant, with copies sent to Landlord.

         12. ACCESS. Landlord or Landlord's agents shall have the right to enter
the Subleased Premises at all reasonable times, upon giving Tenant reasonable
advance notice, to examine the Subleased Premises, to maintain and repair any
improvements installed therein by or on behalf of Landlord.

         13. SELF-HELP. If Tenant shall default in the performance of any of its
obligations hereunder, Landlord at its option may perform such obligations and,
if necessary, enter the Subleased Premises for such purpose. Tenant shall pay to
Landlord, within ten (10) days after demand, the amount of all costs and
expenses incurred by Landlord in the performance of any such obligations. Any
action taken Landlord pursuant to this Article 13 shall not constitute a waiver
of any of Landlord's other rights and remedies hereunder.

                                      -15-
<PAGE>

         14. INTEREST. If Tenant shall fail to pay any installment of rent or
additional rent (other than Interest pursuant to this Article 14) when due,
Tenant shall pay interest thereon at an annual rate equal to four percent (4%)
above the then current prime rate charged by Citibank, N.A. (or the maximum rate
permitted by law, whichever is less), from the date on which such payment is due
to the date of payment thereof.

         15. CONDITION OF PREMISES. The Subleased Premises are demised to Tenant
In the condition which shall exist on the Sublease Commencement Date "as is", it
being understood that neither Landlord nor the Main Landlord shall be obligated
to perform any work or make any installations in the Subleased Premises, or to
otherwise prepare the Subleased Premises for Tenant's occupancy.

         16. DAMAGE OR CONDEMNATION. In the event that the Main Lease is
terminated pursuant to the Main Lease as a result of casualty or condemnation,
then this Sublease shall terminate as of the effective date of the termination
of the Main Lease. In the event, that the Monthly Base Rent (as such term is
defined in the Main Lease) payable under the Main Lease with respect to the
Subleased Premises are abated for any period of time pursuant to the Main Lease,
then payments of rent (but not additional rent pursuant to Paragraph 3(b) of
this Sublease) hereunder shall be abated for the same period of time.

         17. INSURANCE. Tenant shall maintain all insurance required by the Main
Lease and shall deliver to Landlord original policies or certificates evidencing
such insurance, not later that the Sublease Commencement Date or the date Tenant
first occupies the Subleased Premises, whichever is earlier. Any such policy or
certificate shall name Landlord as an additional insured.

         18. BROKERS. Tenant represents that Tenant has dealt with no broker in
connection with this transaction other than CB Commercial Real Estate Group,
Inc. and Trammell Crow

                                      -16-
<PAGE>

Company. Tenant does hereby agree to indemnify, defend and hold Landlord
harmless from and against any and all liability, loss, cost, damage or expense
(including, without limitation, attorneys' fees and disbursements) arising out
of or In connection with any claims made against Landlord by any other broker,
person or entity who claims to have dealt with Tenant in connection with the
leasing of the Subleased Premises.

         19. SUCCESSORS AND ASSIGNS. This Sublease shall be binding upon, and
Inure to the benefit of, the parties hereto and their respective successors and
assigns.

         20. NOTICES. All notices, demands, statements and communications
required hereunder shall be In writing and shall be sent by registered or
certified mail, if to Landlord, addressed to Landlord at:

                        Siemens Medical Systems, Inc.
                        186 Wood Avenue South
                        Iselin, New Jersey 08830
                        Attn:   William Combs

and if to Tenant, addressed to Tenant at:

                        Communications World of Seattle North, Inc.
                        12004-115th Avenue NE
                        Kirkland, Washington 98034
                        Attn:   George Leonard

or to such other address as shall from time to time be designated by written
notice by either party to the other party as herein provided, and shall be
deemed given on the third (3rd) business day after being so mailed.

         21. ENTIRE AGREEMENT. This Sublease embodies the entire understanding
of the parties and there are no further agreements or understandings, written or
oral, in effect between the parties relating to the subject matter hereof.

                                      -17-
<PAGE>

         22. APPROVAL OF MAIN LANDLORD. This Sublease is subject to the written
approval of the Main Landlord pursuant to the Main Lease. Landlord shall
promptly apply to the Main Landlord for such approval, and shall promptly notify
Tenant of such approval or of the denial thereof. In the event the Main Landlord
disapproves this Sublease, all sums theretofore paid to Landlord by Tenant shall
be returned to Tenant without interest, and neither party shall have any further
rights or liabilities hereunder except as specifically provided herein to the
contrary.

         23. SECURITY DEPOSIT. Tenant shall deposit with Landlord on the signing
of this Sublease the sum of $4,228.00 as security for the faithful performance
and observance by Tenant of the terms, conditions and provisions of this
Sublease, including without limitation the surrender of possession of the
Subleased Premises to Landlord as herein provided. It is agreed that in the
event Tenant defaults in respect of any of the terms provisions and conditions
of this Sublease, including, but not limited to, the payment of rent and
additional rent,' Landlord may apply or retain the whole or any part of the
security so deposited to the extent required for the payment of any rent and
additional rent or any other sum as to which Tenant is in default or for any sum
which Landlord may expend or may be required to expend by reason of Tenant's
default in respect of any of the terms, covenants and conditions of this
Sublease, including but not limited to, any damages or deficiency in the
reletting of the Subleased Premises, whether such damages or deficiency accrue
or accrues before or after summary proceedings or other reentry by Landlord. If
Landlord applies or retains any part of the security so deposited, Tenant upon
demand, shall deposit with Landlord the amount so applied or retained so that
Landlord shall have the full deposit on hand at all time during the term of this
Sublease. If Tenant shall fully and faithfully comply with all of the terms,
provisions, covenants and conditions of this Sublease, the security shall be
returned to Tenant after the Expiration Date and after delivery of the entire

                                      -18-
<PAGE>

possession of the Subleased Premises to Landlord. Tenant further covenants that
it will not assign or encumber or attempt to assign or encumber the monies
deposited herein as security and that neither Landlord nor its successors or
assigns shall be bound by any such assignment, encumbrance, attempted assignment
or attempted encumbrance.

         24. MISCELLANEOUS. (a) Landlord covenants and agrees with Tenant that
upon Tenant paying the rent and additional rent and observing and performing all
of the terms, covenants and conditions, on Tenant's part to be observed and
performed, Tenant may peaceably and quietly enjoy the Subleased Premises
subject, nevertheless, to the terms and conditions of this Sublease and the Main
Lease.

         (b) As between the Landlord and Tenant, in the event of a conflict
between the terms, covenants and conditions of this Sublease with the terms,
covenants and conditions of the Main Lease, the terms, covenants and conditions
of this Sublease shall govern. Notwithstanding the foregoing, however, nothing
contained In this Sublease shall be deemed, in any way, to modify the terms,
covenants and conditions of the Main Lease.

         (c) Without limiting anything contained in Paragraph 3(b) hereof,
Landlord hereby covenants and agrees to pay Monthly Base Rent and additional
rent when due under the Main Lease and to comply with and perform all of the
provisions, covenants, conditions and agreements on its part to be done and
performed as tenant under the Main Lease, except for those provisions,
covenants, conditions and agreements assumed by Tenant with respect to the
Subleased Premises under this Sublease and capable of performance by Tenant.

         (d) Landlord hereby represents to Tenant that, as of the date hereof,
(i) the Main Lease is in full force and effect, (ii) to Landlord's best
knowledge, neither the Main Landlord nor

                                      -19-
<PAGE>

Landlord, as tenant, are in default of their respective obligations under the
Main Lease, and (ii) Landlord has not received any notice of default from the
Main Landlord under the Main Lease.

         (e) For the purposes of this Sublease, capitalized terms used but not
defined herein shall have the meanings assigned to them in the Main Lease (such
definitions to be equally applicable to both the singular and plural forms of
the terms defined) unless expressly indicated otherwise. Unless otherwise
indicated, references in this Sublease to sections, paragraphs, clauses,
appendices, schedules and exhibits are to the same contained in or attached to
this Sublease.

         25. MODIFICATIONS. This Sublease may not be modified orally.

                                      -20-
<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Sublease agreement
as of the ___ day of March, 1997.

                           LANDLORD:  SIEMENS MEDICAL SYSTEMS, INC.

                                      By /s/ Peter H. Kroener
                                         --------------------------------------

                                      Name: Peter Kroener
                                            -----------------------------------

                                      Title: VP Finance
                                             ----------------------------------

                                      By /s/ William Combs 3/18/97
                                         --------------------------------------

                                      Name: William Combs
                                            -----------------------------------

                                      Title: Lease Administrator
                                             ----------------------------------
                                             Corporate Real Estate
                                             ----------------------------------

                           TENANT:    COMMUNICATIONS WORLD
                                      OF SEATTLE NORTH, INC.

                                      By: /s/ George L. Leonard
                                          -------------------------------------

                                      Name: George L. Leonard
                                            -----------------------------------

                                      Title: EVP and COO
                                             ----------------------------------

                                      -21-
<PAGE>

                             MAIN LANDLORD'S CONSENT

         Landlord hereby consents to the attached Sublease (the "Sublease"),
dated March 14, 1997, between Siemens Medical Systems, Inc., ("Tenant") as
sublessor, to Communications World International, Inc., ("Subtenant") as
sublessee. Additionally, Landlord agrees and acknowledges that:

         (i) Landlord agrees to waive its right to collect the fee of up to $500
for processing and leasing pursuant to Paragraph 12(A) of the Main Lease in
connection with the Sublease; and all other provisions of Paragraph 12(A) remain
in force.

         (ii) There are no defaults on the part of Landlord or Tenant under the
Main Lease, as of the date hereof.

                                      THE RIGGS NATIONAL BANK OF
                                      WASHINGION, D.C., as Trustee
                                      of the Multi-Employer Property Trust

                                      By: /s/ Leanne Tobias
                                          -------------------------------------

                                      Name: Leanne Tobias
                                            -----------------------------------

                                      Title: Vice President
                                             ----------------------------------

                                      -22-
<PAGE>

                            CONSENT OF MAIN LANDLORD

         Riggs & Company, a division of Riggs Bank NA, formerly known as The
Riggs National Bank of Washington, D.C., as Trustee of the Multi-Employer
Property Trust, the Landlord ("Landlord") under that certain Lease Agreement
dated June 1, 1995, as amended, by and between Landlord and Siemens Medical
Systems, Inc., as Tenant (the "Main Lease"), hereby consents to the assignment
of the Sublease, and additionally agrees and acknowledges that

         (a) Landlord reserves the right to collect up to two hundred fifty
dollars ($250.00) of the processing and leasing fee pursuant to Paragraph 12(A)
of the Main Lease in connection with the Assignment, provided that all other
portions of Section 12(A) shall remain in force and effect; and

         (b) As of the date of this Agreement, to Landlord's actual knowledge,
which for purposes of this Agreement means to the actual knowledge of Peter
Crolius, without duty of further Investigation, there are no defaults on the
part of Landlord or Tenant under the Main Lease, as of the date hereof.

RIGGS & COM0ANY. A DIVISION OF RIGGS BANK N.A..
FORMERLY KNOWN AS THE RIGGS NATIONAL BANK OF WASHINGTON. D.C.,
AS TRUSTEE OF THE MULTIEMPLOYER PROPERTY TRUST,

By: /s/ Leanne Tobias

Name: Leanne Tobias

Its: Managing Director

Date: 8/19/98

                                      -23-
<PAGE>

                              AMENDMENT OF SUBLEASE

         THIS AGREEMENT (the "Amendment") made of as the ____ day of August,
1998, between Siemens Medical Systems, Inc., a Delaware corporation, having an
address at 186 Wood Avenue South, Iselin, NJ 08830 (the "Landlord") and Rosetta
Inpharmatics, a Delaware corporation, having an office at 12040 115th Avenue NE,
Kirkland, WA 98034, (the "Subtenant").

                                   WITNESSETH:

         WHEREAS, by Sublease Agreement (as amended, the "Sublease"), dated
March 14, 1997, between Sublandlord and Communications World of Seattle North
("CWSN"), Tenant, Landlord did demise and let unto CWSN and CWSN did hire and
take from Sublandlord, the premises described in the Sublease (the "Demised
Premises") and

         WHEREAS, CWSN assigned its interest in and to the Sublease to Subtenant
and Subtenant did accept such assignment and assume all of the obligations of
CWSN in and to the Sublease pursuant to that certain Sublease Assignment and
Assumption Agreement, dated as of August .._, 1998; and

         WHEREAS, Sublandlord and Subtenant desire to modify, amend and
supplement the Lease on the terms, covenants and conditions more particularly
set forth herein.

         NOW, THEREFORE, in consideration of the sum of Ten Dollars ($10.00)
paid by Tenant to Landlord and for other good and valuable consideration, the
mutual receipt and legal sufficiency of which are hereby acknowledged, the
parties hereto agree as follows:

                                      -24-
<PAGE>

         1. Section 23 of the Sublease is hereby amended to increase the amount
being held as security under the Sublease to $8,456.00, of which $4228.00 is the
amount previously paid by CWSN and $4,228.00 is the amount to be paid by
Subtenant.

         Except as expressly modified, amended and supplemented by the
Amendment, all of the forms, covenants and conditions of the Sublease shall
remain in full force and effect. All defined terms used herein shall have the
meanings ascribed to such terms in the Sublease, unless specifically define
herein.

         IN WITNESS WHEREOF, the parties hereto have caused the Amendment to be
executed as of the day and year first above written.

                                      SIEMENS MEDICAL SYSTEMS, INC.,
                                      Sublandlord

                                      By:
                                         --------------------------------------
                                      Name:
                                      Title:
                                      Date:

                                      ROSETTA INPHARMATICS
                                      Subtenant

                                      By: /s/ John J. King II
                                          -------------------------------------
                                      Name: John J. King II
                                      Title: Sr. Vice President
                                      Date: 8/12/98

                                      COMMUNICATIONS WORLD OF
                                      SEATTLE NORTH
                                      CWSN

                                      By:
                                         --------------------------------------
                                      Name:
                                      Title:
                                      Date:

                                      -25-<PAGE>

                                     ROSETTA
                                  INPHARMATICS

March 13, 2000

Mark Boguski, M.D., Ph.D
4 Seville Way
Gaithersburg, MD 20878

VIA FEDEX

Dear Mark,

         On behalf of ROSETTA INPHARMATICS, Inc. (the "Company"), I am pleased
to offer you the position of Senior Vice President, Research. Speaking for
myself, as well as the other members of the Company's management team and the
Company's Board of Directors, we are all very impressed with your credentials
and we look forward to your future success in this position.

         The terms of your new position with the Company are as set forth below:

         1. POSITION.

            a. You will become the Senior Vice President of Research working at
the Company's Kirkland office, under my direction as Chief Executive Officer. In
this position, you will serve as an Officer of the Corporation and as a member
of the Company's Senior Management Team.

            b. You agree to the best of your ability and experience that you
will at all times loyally and conscientiously perform all of the duties and
obligations required of and from you pursuant to the express and implicit terms
hereof, and to the reasonable satisfaction of the Company. During the term of
your employment, you further agree that you will devote all of your business
time and attention to the business of the Company, the Company will be entitled
to all of the benefits and profits arising from or incident to all such work
services and advice, you will not render commercial or professional services of
any nature to any person or organization, whether or not for compensation,
without the prior written consent of the Company's Board of Directors, and you
will not directly or indirectly engage or participate in any business that is
competitive in any manner with the business of the Company. Nothing in this
letter agreement will prevent you from having an affiliation with an academic
institution involving no more than 4 hours per week, accepting speaking or
presentation engagements in exchange for honoraria or from serving on boards of
charitable organizations, or from owning no more than one percent (1%) of the
outstanding equity securities of a corporation whose stock is listed on a
national

<PAGE>

March 13, 2000
Page 2

stock exchange. The Company understands that you are currently a Member of Orion
Genomics L.L.C. and agrees that you will retain your equity interest in such
entity.

         2. START DATE. Subject to fulfillment of any conditions imposed by this
letter agreement, you will commence this position with the Company on or before
March 20, 2000. The Company understands that you will initially work a part-time
schedule, minimum of one day per week, for a period not to exceed six weeks. You
will begin working full-time at the Company on the Company's premises no later
than June 1, 2000 (the "FULL TIME START DATE").

         3. PROOF OF RIGHT TO WORK. For purposes of federal immigration law, you
will be required to provide to the Company documentary evidence of your identity
and eligibility for employment in the United States. Such documentation must be
provided within three business days of your date of hire, or your employment may
be terminated.

         4. COMPENSATION.

            a. BASE SALARY. You will be paid a monthly salary of $17,500, which
is equivalent to $210,000 on an annualized basis. Your salary will be payable in
two equal payments per month pursuant to the Company's regular payroll policy
(or in the same manner as other employees of the Company).

            b. ANNUAL REVIEW. Your base salary will be reviewed at the end of
each calendar year as part of the Company's normal salary review process. To the
extent that cost of living or other across the board adjustments in base salary,
options, benefits or other compensation are made with respect to all other
members of the Company's Senior Management Team, your base salary, options,
benefits or other compensation will similarly be adjusted, on a good faith
basis. Merit increases or decreases with respect to your salary will be treated
separately and shall be subject to determination by the Compensation Committee
of the Board of Directors of the Company, in its sole discretion on a case by
case basis.

         5. STOCK OPTIONS.

            a. INITIAL OPTION GRANT. In connection with the commencement of your
employment, the Company will, upon approval by the Board of Directors, grant you
an option to purchase 300,000 shares (subject to stock splits and
recapitalizations) of the Company's Common Stock (the "Shares") with an exercise
price equal to $5.25. These options will vest in accordance with the following
schedule: twelve and one-half percent (12 1/2%) of the Shares shall vest on the
Full Time Start Date and 1/48th of the total number of Shares shall vest each
month thereafter. Vesting will, of course, depend on your continued employment
with the Company. The option will be a nonstatutory stock option, and will be
subject to the terms of the Company's 1997 Stock Option Plan and the Stock
Option Agreement between you and the Company. The parties agree that the fair
market value of the Shares as of the date of this Agreement for federal income
tax purposes is $5.25 per share. The parties hereto agree to file

<PAGE>

March 13, 2000
Page 3

their respective federal, state and local tax returns (including any IRS Form
W-2 or 1099) consistent with this stipulated value. In the event the Company's
1997 Stock Option Plan does not provide for assumption of your option (or
vesting stock, as the case may be) in the event of a consolidation or merger (a
"Merger Event") of the Company, your Stock Option Agreement will be amended to
provide that your options will accelerate (in such a case of non-assumption) by
100%.

            b. SUBSEQUENT OPTION GRANTS. Subject to the discretion of the
Company's Board of Directors, and subject to Section 4(b) above, you may be
eligible to receive additional grants of stock options from time to time in the
future, on such terms and subject to such conditions as the Board of Directors
shall determine as of the date of any such grant.

         6. RELOCATION PACKAGE.

            a. FULL TIME START BONUS. The Company will provide you with a bonus
of $135,000, payable upon your Full Time Start Date (the "SIGNING BONUS"). To
the extent that you incur costs associated with your transition to the Company
prior to your Full Time Start Date, the Company will reimburse you for such
costs and will deduct such costs from the Signing Bonus. If you voluntarily
terminate your employment with the Company within the first 12 months of
employment, you will reimburse the Company for 50% of your Signing Bonus. If you
voluntarily terminate your employment within the second 12 months of employment,
you will be expected to reimburse the Company for 25% of your Signing Bonus. The
Signing Bonus and relocation expenses paid by the Company may be considered
taxable income to you.

            b. COMMUTING. During the initial six-month transition period
commencing with the date of this letter agreement, the Company agrees to
reimburse your reasonable door to door travel expenses, which are expected to be
incurred on a weekly basis. In addition, the Company agrees to reimburse your
reasonable lodging expenses. Expenses are reimbursed upon presentation of
receipts. Reimbursement of these expenses is in addition to, and shall not
reduce, the Signing Bonus.

            c. PROFESSIONAL FEES. The Company shall reimburse you the sum of
$5,000 towards your attorneys' fees incurred in the drafting, negotiation and
execution of this agreement.

         7. BENEFITS. Subject to the provisions of Section 4(b) above, you will
be provided with the following benefits:

            a. INSURANCE BENEFITS. The Company will provide you with standard
medical, dental, long-term disability and group life insurance benefits in
accordance with the Company's policies in effect from time to time.

<PAGE>

March 13, 2000
Page 4

            b. VACATION. You will be entitled to paid vacation each year, under
the Company's vacation policy in effect from time to time.

            c. 401(K) PLAN. You will be eligible to participate in the ROSETTA
INPHARMATICS 401(k) Plan on the first day of the quarter following your Full
Time Start Date.

            d. FLEXIBLE SPENDING ACCOUNT. You will be eligible to participate in
a Flexible Spending Account on the first day of the month following your date of
hire.

            e. INDEMNIFICATION AGREEMENT. You will be provided indemnification
pursuant to the Company's standard form of Indemnification Agreement, a copy of
which is attached hereto as Exhibit A.

         8. SEVERANCE AGREEMENT.

            a. If your employment is terminated by the Company or its successor
for any reason other than for "good" cause than you will immediately resign from
all positions with the Company and enter into a consulting arrangement for one
(1) year commencing immediately after your termination date, provided the scope
of your duties/services are not materially increased by virtue of your becoming
a consultant. In consideration for such consulting arrangement, you will
continue to be paid your salary and benefits for one (1) year and will become
vested over such one (1) year period in the lesser of (I) an additional one (1)
year of shares covered by your Stock Option Agreement, or (ii) the remaining
unvested shares pursuant to your Stock Option Agreement; provided, however, that
if you obtain new employment during such one (1) year period, any salary paid
pursuant to such arrangement will be offset from base salary due under this
Letter Agreement; and provided further that you are under no duty to seek other
employment upon such termination. For purposes of this letter agreement, "good
cause" shall mean (a) gross misconduct which continues after prior written
notice from the Company to you and your failure to cure such conduct within
thirty (30) days of your receipt of such notice or (b) acts or omissions
constituting fraud, embezzlement or dishonesty.

            b. In the event that your employment is involuntarily terminated by
the Company for "good cause," you will immediately resign from all positions
with the Company and the Company's obligations hereunder will immediately
terminate.

         9. CONFIDENTIAL INFORMATION AND INVENTION ASSIGNMENT AGREEMENT. Your
acceptance of this offer and commencement of employment with the Company is
contingent upon the execution, and delivery to an officer of the Company, of the
Company's Confidential Information and Invention Assignment Agreement, a copy of
which is enclosed for your review and execution (the "CONFIDENTIALITY
AGREEMENT"), prior to or on your Start Date.

<PAGE>

March 13, 2000
Page 5

         10. CONFIDENTIALITY OF TERMS. You agree to follow the Company's strict
policy that employees must not disclose, either directly or indirectly, any
information, including any of the terms of this agreement, regarding salary,
bonuses, or stock purchase or option allocations to any person, including other
employees of the Company; provided, however, that you may discuss such terms
with members of your immediate family and any legal, tax or accounting
specialists who provide you with individual legal, tax or accounting advice.

         11. TERM. Your employment with the Company will be on an "at will"
basis, meaning that either you or the Company may terminate your employment at
any time for any reason or no reason, without further obligation or liability.

         We are delighted to be able to extend you this offer and look forward
to working with you. To indicate your acceptance of the Company's offer, please
sign and date this letter in the space provided below and return it to me, along
with a signed and dated copy of the Confidentiality Agreement. This letter,
together with the Confidentiality Agreement, set forth the terms of your
employment with the Company and supersede any prior representations or
agreements, whether written or oral. This letter may not be modified or amended
except by a written agreement, signed by the Company and by you.

Very truly yours,

ROSETTA INPHARMATICS, INC.

/s/ Stephen H. Friend

Stephen H. Friend, M.D., Ph.D, President

ACCEPTED AND AGREED:

MARK BOGUSKI, M.D., PH.D.

/s/ Mark  Boguski
-------------------------
Signature

-------------------------
Date

Enclosure:    Confidential Information and Invention Assignment Agreement
              Benefit Summary
              Senior Management Relocation Package
              Indemnification Agreement

<PAGE>

March 13, 2000
Page 6

                                     ROSETTA
                                  INPHARMATICS

March 14, 2000

Mark Boguski, M.D., Ph.D
4 Seville Way
Gaithersburg, MD 20878

         RE: ROSETTA INPHARMATICS, INC. (THE "COMPANY")

Dear Mark,

         The Company hereby agrees, as an additional inducement to your becoming
an employee and officer of the Company, pursuant to that certain Promissory Note
between you and the undersigned dated as of March 14, 2000 (the "NOTE"), that in
the event of your death or permanent disability or termination without good
cause (as such term is defined in the employment offer letter agreement between
you and the Company dated March 13, 2000) within one year of a Change in Control
(as such term is defined in Section 3(a)(iii) of that certain Early Exercise
Notice and Restricted Stock Purchase Agreement between you and the Company dated
as of March 14, 2000) while the Note remains outstanding, the Note shall no
longer be full recourse such that Company's sole and exclusive remedy for your
default, in such event, shall be recovery of the pledged shares, and the Company
shall not pursue any deficiency against you.

Please acknowledge your acceptance of this letter agreement by signing where
indicated below. This letter agreement may be executed in counterparts each of
which shall be deemed an original and which together shall constitute one
document. Once signed by the Company and you, this letter will serve as a
modification and allonge to the Note which shall be attached to the original
thereof.

                           ROSETTA INPHARMATICS, INC.

                           By: /s/ Stephen Fried
                              -------------------------------

                           Its: President & CEO
                                -----------------------------
Agreed and Acknowledged:

<PAGE>

March 13, 2000
Page 7

-------------------------------------
Mark Boguski, M.D., Ph.D.

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