Document:

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                                                                 EXHIBIT 10.13.a
                         SUBSIDIARY GUARANTY SUPPLEMENT

To the Holders of the 6.54% Senior Notes
  due March 15, 2010
  of Granite Construction Incorporated
  (the "Company")

Ladies and Gentlemen:

       WHEREAS, in order to refinance existing indebtedness and for general
corporate purposes, the Company issued its 6.54% Senior Notes due March 15, 2010
in the aggregate principal amount of $60,000,000 (the "Notes") pursuant to that
certain Note Purchase Agreement dated as of May 1, 2001 (as amended to the date
hereof, the "Note Agreement") between the Company and each of the purchasers
named on Schedule A attached to said Note Agreement (the "Initial Note
Purchasers").

       WHEREAS, as a condition precedent to their purchase of the Notes, the
Initial Note Purchasers required that certain from time to time subsidiaries of
the Company enter into a Subsidiary Guaranty Agreement as security for the Notes
(the "Subsidiary Guaranty").

       Pursuant to Section 9.6(a)(l) of the Note Agreement, the Company has
agreed to cause the undersigned, Granite Halmar Construction Company, Inc., a
corporation organized under the laws of New York (the "Additional Guarantor"),
to join in the Subsidiary Guaranty. In accordance with the requirements of the
Subsidiary Guaranty, the Additional Guarantor desires to amend the definition of
Guarantor (as the same may have been heretofore amended) set forth in the
Subsidiary Guaranty attached hereto so that at all times from and after the date
hereof, the Additional Guarantor shall be jointly and severally liable as set
forth in the Subsidiary Guaranty for the obligations of the Company under the
Note Agreement and Notes to the extent and in the manner set forth in the
Subsidiary Guaranty.

       The undersigned is the duly elected _Vice President______ of the
Additional Guarantor, a subsidiary of the Company, and is duly authorized to
execute and deliver this Guaranty Supplement to each of you. The execution by
the undersigned of this Guaranty Supplement shall evidence its consent to and
acknowledgment and approval of the terms set forth herein and in the Subsidiary
Guaranty and by such execution the Additional Guarantor shall be deemed to have
made in favor of the Holders the representations and warranties set forth in
Section 5 of the Subsidiary Guaranty.

       Upon execution of this Subsidiary Guaranty Supplement, the Subsidiary
Guaranty shall be deemed to be amended as set forth above. Except as amended
herein, the terms and provisions of the Subsidiary Guaranty are hereby ratified,
confirmed and approved in all respects.

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       Any and all notices, requests, certificates and other instruments
(including the Notes) may refer to the Subsidiary Guaranty without making
specific reference to this Subsidiary Guaranty Supplement, but nevertheless all
such references shall be deemed to include this Subsidiary Guaranty Supplement
unless the context shall otherwise require.

       Dated: November 15__, 2001.

                                       GRANITE HALMAR CONSTRUCTION COMPANY, INC.

                                       By  /s/ R.C. Allbritton
                                         ---------------------------------
                                           Its  R.C. Allbritton
                                              Vice President

                                           /s/ James H. Roberts
                                         ---------------------------------
                                           Its  James H. Roberts
                                              Vice President

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The undersigned Guarantors hereby acknowledge and agree to the foregoing and
hereby ratify and re-affirm the Guaranty Agreement.

                                        GRANITE CONSTRUCTION COMPANY

                                        By    /s/ R.C. Allbritton
                                          ---------------------------------
                                            Its  R. C. Allbritton
                                              Vice President

                                              /s/ James H. Roberts
                                          ---------------------------------
                                            Its  James H. Roberts
                                              Vice President

                                        GRANITE LAND COMPANY

                                        By    /s/ R.C. Allbritton
                                          ---------------------------------
                                            Its  R.C. Allbritton
                                               Vice President

                                              /s/ James H. Roberts
                                          ---------------------------------
                                            Its  James H. Roberts
                                               Vice President

                                        INTERMOUNTAIN SLURRY SEAL, INC.

                                        By    /s/ Michael L. Thomas
                                          ---------------------------------
                                            Its  Michael L. Thomas
                                               President

                                        POZZOLAN  PRODUCTS COMPANY

                                        By    /s/ Michael L. Thomas
                                          ---------------------------------
                                            Its  Michael L. Thomas
                                               President

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                                        GILC, L.P.

                                        By: GILC Incorporated, its sole General
                                            Partner

                                        By    /s/ R.C. Allbritton
                                          ---------------------------------
                                            Its  R.C. Allbritton
                                               Vice President

                                              /s/ Michael Futch
                                          ---------------------------------
                                            Its  Michael Futch
                                               Secretary

                                        G.G.&R., INC.

                                        By    /s/ Michael Futch
                                          ---------------------------------
                                            Its  Michael Futch
                                               Secretary

                                          ---------------------------------
                                            Its

                                        GRANITE HALMAR CONSTRUCTION
                                          COMPANY, INC.

                                        By    /s/ R.C. Allbritton
                                          ---------------------------------
                                            Its  R.C. Allbritton
                                               Vice President

                                              /s/ James H. Roberts
                                         ---------------------------------
                                            Its  James H. Roberts
                                               Vice President<PAGE>
                                                                   EXHIBIT 10.41

                                LICENSE AGREEMENT

        THIS LICENSE AGREEMENT (this "Agreement") is made as of the 21st day of
December, 2001 (the "Effective Date") by and between The University of
Connecticut Health Center, a public institution of higher education, having a
business address at the Center for Science and Technology Commercialization, 263
Farmington Avenue, Farmington, Connecticut 06030-6207 (hereinafter referred to
as "UCHC") and InSite Vision Incorporated, a Delaware corporation with its
principal place of business at 965 Atlantic Avenue, Alameda, California 94501
(hereinafter referred to as "Licensee"). (UCHC and Licensee each individually a
"Party" and collectively, the "Parties".)

                                    RECITALS

        WHEREAS, the UCHC laboratory of Dr. Mansoor Sarfarazi (the "Laboratory")
has invented technology for genetic-based prognosis and diagnosis of Adult Onset
Primary Open Angle Glaucoma ("POAG"), as defined under Section 1.7 hereof, which
technology is being developed under a Research Agreement dated June 29, 2001
between UCHC and Licensee (the "Research Agreement.

        WHEREAS, UCHC owns UCHC Technology and Patent Rights, as defined below,
related to the POAG technology;

        WHEREAS, Licensee desires to secure a license to use such UCHC
Technology and Patent Rights to produce, use and sell Licensed Products related
to POAG, under the terms and conditions set forth herein; and

        WHEREAS, UCHC desires to facilitate a timely transfer of its
information and technology concerning the UCHC Technology and the Patent Rights
related to POAG for the ultimate benefit of the public and this transfer is best
accomplished by the grant of this license;

        NOW THEREFORE, for and in consideration of the covenants, conditions,
and undertakings hereinafter set forth, it is agreed by and between the Parties
as follows:

                                    AGREEMENT

1.      Definitions.

        1.1    "UCHC Technology" means any research and development information,
know-how, and technical data relating to POAG that has been developed in the
Laboratory and under the Research Agreement, that relates to the practice of the
Patent Rights relating to prognosis and diagnosis of POAG and that UCHC has the
right to provide to Licensee.

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        1.2    "Licensed Products" means any method, procedure, process,
prognostic kit, diagnostic kit, product, or component part thereof whose
manufacture, sale or use includes a material use of UCHC Technology or Patent
Rights for the prognosis and/or diagnosis of POAG.

        1.3    "Patent Rights" means all patent rights of UCHC to: (a) any
inventions (including, without limitation, any apparatus, technique, process,
means or method) relating to the prognosis and/or diagnosis of POAG that is
developed, conceived or reduced to practice during the course of the Research
Agreement including, without limitation, any subject matter relating to the
prognosis and/or diagnosis of POAG described by, claimed in or covered by
University of Connecticut invention disclosure [*] (the "Existing Disclosure");
(b) any United States patent applications that may be based on any of the
foregoing and any United States patents issuing from such applications; and (d),
any continuations, continuations-in-part ("CIP"), divisions and substitutions
thereof, and any foreign patents corresponding thereto, and/or any divisions,
continuations, or reissues thereof; provided, however, that in order to be
included in Patent Rights, the new subject matter contained in any CIP, or
foreign counterparts thereto, must (i) have been developed in the Laboratory
during the term of the Research Agreement and as a result of the work performed
under the Research Agreement, and (ii) relate to prognosis and/or diagnosis of
POAG.

        1.4    "Net Sales" means total billings for Licensed Products,
determined in accordance with generally accepted accounting principles, sold by
Licensee and its Affiliates, less:

               (a)    import, export, excise, use, value-added and sales taxes,
and custom duties actually paid by Licensee to the extent separately stated on
invoices or other sales documents;

               (b)    to the extent actually paid by Licensee, costs of
insurance, packing, and transportation from the place of manufacture to the
customer's premises or point of installation to the extent separately stated on
invoices or other sales documents;

               (c)    credit for returns, allowances, and discounts actually
allowed by Licensee; and

               (d)    Medicaid rebates and rebates actually allowed by Licensee
made or taken in amounts customary in the industry.

         Licensed Products shall be considered sold when paid for or thirty (30)
days after invoiced, whichever is sooner.

        1.5    "Affiliate" means any entity which controls, is controlled by or
is under common control with Licensee. An entity shall be regarded as in control
of another entity if it owns or controls more than fifty percent (50%) of the
voting power of such entity.

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        1.6    "Valid Claim" means a claim of an issued, unexpired patent which
has not been: held invalid or unenforceable by a final decision of a court or
governmental agency of competent jurisdiction, which decision is unappealable or
was not appealed within the time allowed therefore; or admitted in writing to be
invalid or unenforceable by the holder(s) pursuant to a reissue, disclaimer or
otherwise.

        1.7    "POAG" means Adult Onset Primary Open Angle Glaucoma related to
the GLC1E locus and other GLC1 loci, if any, for which the Laboratory identifies
mutations under the terms of the Research Agreement.

2.      Grant of License and Term.

        2.1    License Grant. Subject to Section 6 (Government Rights) and
Section 10 (UCHC Use):

               (a)    UCHC grants to Licensee and its Affiliates an exclusive
(including as to UCHC), worldwide right and license to use UCHC Technology, and
to make, have made, use, import, export, sell and offer to sell Licensed
Products incorporating, made, using or derived from UCHC Technology, upon the
terms and conditions of this Agreement.

               (b)    UCHC grants to Licensee and its Affiliates an exclusive
(including as to UCHC), worldwide license under the Patent Rights to make, have
made, use, import, export, sell and offer to sell Licensed Products, and to
practice any process, method or procedure covered by the Patent Rights, upon the
terms and conditions set forth herein.

               (c)    The rights and licenses granted under Section 2.1(a) and
Section 2.1(b) above shall include the exclusive (including as to UCHC) right to
grant sublicenses.

        2.2    Background Technology. UCHC grants to Licensee and its Affiliates
a non-exclusive worldwide right and license under any intellectual property or
propriety rights from the laboratory of Dr. Sarfarazi owned by UCHC and to which
UCHC has the right to license hereunder (other than as set forth above) to the
extent necessary for Licensee to: (a) practice any process, method or procedure
covered by the Patent rights; or (b) otherwise use any UCHC Technology to make,
have made, use, import, sell and offer to sell Licensed Products as set forth
herein.

        2.3    Disclosure of Technology. UCHC shall promptly disclose to
Licensee the UCHC Technology and provide Licensee with copies of the physical
embodiments thereof and any invention disclosures and other documentation with
respect thereto. UCHC shall provide Licensee with reasonable assistance
sufficient to enable Licensee to understand and implement the UCHC Technology
and Patent Rights related to POAG. The amount of such assistance to be provided
by Dr. Mansoor Sarfarazi will be mutually agreed by Dr. Sarfarazi and Licensee,
and Dr. Sarfarazi will be compensated for time spent providing such assistance
at the same rate as for services provided pursuant to his existing consulting
agreement with Licensee.

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        2.4    Improvements. In the event that the Laboratory develops any
enhancements or improvements relating to the prognosis and diagnosis of POAG
("Improvements") as a result of the work performed under the Research Agreement
during the time the Research Agreement is in effect, UCHC shall promptly notify
Licensee of such Improvements in writing and provide Licensee with a detailed
written description of such Improvements. Such Improvements are included under
the rights granted in this Agreement and all rights granted to Licensee herein
with respect to the UCHC Technology and the Patent Rights shall apply to such
Improvements.

        2.5    Therapeutic Use. During the term of the Research Agreement,
Licensee shall have the option, as described in Article 9 of the Research
Agreement, to obtain from UCHC an exclusive, worldwide right and license to use
any invention relating to POAG which has been developed in the Laboratory and
which relates to therapeutic approaches to POAG and which UCHC has the right to
provide to Licensee. The terms and conditions of such license shall be
determined in good faith.

3.      License Fees and Royalties.

        3.1    Issue Fee and Milestone Payments. Licensee shall pay to UCHC a
license issue fee of [*] upon the execution of this Agreement. In addition,
Licensee shall pay to UCHC the following milestone payment: [*] upon the first
commercial sale of Licensed Products. For the purpose of this Section 3.1 (Issue
Fee and Milestone Payments), payment shall be made to UCHC within thirty (30)
days of the applicable triggering event.

3.2     Royalties.  Licensee shall pay UCHC:

        (a)    [*] of Net Sales of Licensed Products for prognostic or
diagnostic use as earned royalties, provided that such Licensed Products are
covered by a Valid Claim in the country in which, and at the time, they are
sold, provided, however, that the foregoing earned royalty rate of [*] shall be
reduced to an earned royalty equal to the UCHC Portion (as defined below)
multiplied by [*] in the case of sales of Licensed Products that incorporate the
UCHC Technology or the Patent Rights and components licensed by Licensee from
other third parties. The "UCHC Portion" means the portion of the total
detectable incidence of Primary Open Angle Glaucoma in the target population
defined by the Parties that is attributable to the detection capabilities of
and/or the genes identified by the UCHC Technology and the Patent Rights.
Documentation for the above calculation will be based on the reported results of
the UCHC research and on other relevant data from published materials; and

        (b)    [*] of Net Sales of licensed Products for prognostic or
diagnostic use as earned royalties, provided that such Licensed Products are not
covered by a Valid Claim in the country in which, and at the time, they are
sold, provided, however, that the foregoing earned royalty rate of [*] shall be
reduced to an earned royalty equal to the UCHC Portion multiplied by [*] in the
case of sales of licensed Products that incorporate the UCHC Technology and

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components licensed by Licensee from other third parties. Documentation for the
above calculation will be based on the reported results of the UCHC research and
on other relevant data from published materials.

        3.3    Yearly Minimum Payments. On each anniversary of the Effective
Date of this Agreement, Licensee shall pay to UCHC the amount, if any, by which
the following minimum annual royalty payments exceed the earned royalty payments
made by Licensee to UCHC pursuant to Section 3.2 (Royalties) above for the
corresponding year:

                        First license year                  [*]

                        Second license year                 [*]

                        Third license year                  [*]

                        Fourth license year                 [*]

                        Fifth license year                  [*]

                        Each year thereafter during the     [*]
                        term of this Agreement

        3.4    Payment Remedies. Notwithstanding any provision of this Agreement
to the contrary, in the event of Licensee's breach of any of its obligations
under Section 3 (License Fees and Royalties), UCHC shall have the right, at its
sole discretion, to terminate this Agreement or to convert the exclusive
licenses granted under Section 2.1 (License Grant) hereof to non-exclusive
licenses upon providing Licensee with written notice of such conversion if
Licensee has failed to cure any such breach within ninety (90) days of receipt
of written notice from UCHC describing such breach.

        3.5    Sublicense Fees. Notwithstanding any provision of this Agreement
to the contrary, Licensee shall pay to UCHC:

               (a)    [*] of royalties that Licensee and/ or its Affiliates
receive as earned royalty income from sublicensees, up to the amount that UCHC
would receive if such sales had been made by Licensee; and

               (b)    [*] of all sublicensing income, exclusive of royalty
income covered by Section 3.5(a) that Licensee and/ or its Affiliates receive
from sublicensees, including, but not limited to, initial sublicensing fees,
minimums, maintenance fees, the value of equity or other ownership interest, and
milestone payments.

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Licensee shall provide UCHC with a complete copy of each sublicense granted by
Licensee within thirty (30) days of execution of such sublicense.

        3.6    Single Accrual of Royalties and Fees. Sales of Licensed Products
between or among Licensee, its Affiliates and sublicensees shall not be subject
to any royalty hereunder, and in such cases royalties shall be calculated upon
Licensee's or its Affiliates' or sublicensees' Net Sales to an independent third
party. Licensee shall be responsible for payment of any royalty accrued on Net
Sales of Licensed Products to such independent third party through Licensee's
Affiliates or sublicensees. Royalties shall accrue hereunder only once in
respect of the same unit of the Licensed Product.

4.      Timing of Royalty Payments: Records.

        4.1    Payment of Royalties and Fees. Within forty-five (45) days after
the end of each calendar quarter, Licensee shall pay to UCHC the royalty payment
and sublicensing income due for such quarter in U.S. dollars. Such royalties
shall be converted, where applicable, from the currency of the country in which
the sale was made into U.S. dollars in accordance with generally accepted
accounting principles.

        4.2    Reports. Together with each quarterly payment, Licensee shall
submit to UCHC a written accounting showing its computation of royalties and
sublicensing income due under this Agreement for such quarter. Said accounting
shall set forth gross sales, credits and other offsets, Net Sales, total
sublicensing income, the exchange rate applied, if any, and the total payment
due for the quarter in question.

        4.3    Books and Records. Licensee shall keep full and accurate books
and records reflecting the sales of Licensed Products and the data used in
arriving at Net Sales and the amount of royalties and/or share of sublicense
income payable to UCHC hereunder for no less than three (3) years after the end
of each such quarter. Licensee shall permit UCHC, at UCHC's expense, to have
such books and records examined by independent certified public accountants
retained by UCHC and reasonably acceptable to Licensee, during regular business
hours upon reasonable advance notice, but not later than three (3) years
following the rendering of any such reports, accounting and payments, and no
more often than one (1) time per year. Such independent accountants shall keep
confidential any information obtained during such examination and shall report
to UCHC only the amounts of royalties and/or share of sublicense income which
the independent accountant believes to be due and payable hereunder.

5.      Due Diligence.

        Licensee shall use its reasonable commercial efforts to proceed with the
research, development and commercialization of Licensed Products and shall
thereafter use its reasonable commercial efforts to commercialize and sell the
Licensed Products so developed during the term of this Agreement. If Licensee
has not made commercial sales of Licensed Products within five (5) years after
the Effective Date, UCHC may terminate this Agreement upon [one hundred

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and eighty (180) days] prior written notice at the sole discretion of UCHC
provided that Licensee has not commenced such commercial sale within such notice
period.

6.      Government Rights.

        Notwithstanding Section 2.1 (License Grant), Section 2.2 (Background
Technology), or Section 2.4 (Improvements) above, any and all licenses granted
hereunder are subject the following rights of the United States Government which
arise out of its partial sponsorship of the research which led to the UCHC
Technology or the Patent Rights: (a) a nonexclusive, nontransferable,
irrevocable, paid-up license to practice or have practiced for or on behalf of
the United States any invention within the Patent Rights throughout the world
(as and to the extent set forth under the applicable provisions of 35 U .S.C.
Section 200 et seq.); and (b) march-in rights as provided in 35 U.S.C. Section
203. Upon the written request of the Licensee, UCHC will use reasonable efforts
to obtain a waiver of the requirement under 35 U .S.C. Section 203 that products
embodying such inventions or produced through the use of such inventions sold in
the United States be manufactured substantially in the United States.

7.      Term and Termination.

        7.1    Term. Unless earlier terminated in accordance with this Section 7
(Term and Termination), this Agreement and the licenses granted herein shall
continue until the later of: (a) the expiration of the last-to-expire patent
within the Patent Rights, (b ) the abandonment of the last application within
the Patent Rights or (c) fifteen (15) years from the Effective Date of this
Agreement. Upon the expiration, but not the earlier termination of this
Agreement, Licensee's rights under Section 2.1(a) (License Grant) and Section
2.2 (Background Technology) shall survive.

        7.2    Termination by UCHC. UCHC may terminate this Agreement if
Licensee is: (a) in significant breach of a material term of this Agreement and
Licensee fails to remedy such breach within sixty (60) days after written notice
of breach from UCHC is received by Licensee; (b) adjudged bankrupt; (c) enters
into a composition with its creditors; or (d) makes an assignment for the
benefit of its creditors with respect to substantially all of its assets.

7.3     Termination by Licensee.

               (a)    Licensee may terminate this Agreement if UCHC is in
significant breach of a material term of this agreement and UCHC fails to remedy
such breach within sixty (60) days after written notice of such breach from
Licensee is received by UCHC.

               (b)    In addition to the foregoing, Licensee may also terminate
this Agreement at any time upon one hundred eighty (180) days written notice to
UCHC, provided that Licensee shall be obligated to pay to UCHC all milestone,
minimum, earned royalty, sublicense income or other amounts due and payable to
UCHC as of the effective date of the written notice.

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               (c)    In addition to the above, if Licensee terminates this
Agreement pursuant to Section 7.3(b) within five (5) years after the Effective
Date, and if Licensee, together with its sublicensees and Affiliates, has failed
to achieve aggregate commercial sales of Licensed Products averaging at least
[*] per year as of the effective date of such termination, Licensee shall also
pay to UCHC an early termination fee equal to [*] of minimum royalties as
outlined in Section 3.3 (Yearly Minimum Payments) and as calculated for the [*]
after the effective date of the termination. All payments required under this
Section 7.3 (Termination by Licensee) shall be paid to UCHC within thirty (30)
days of the effective date of such termination.

        7.4    Survival. The provisions of Section 1 (Definitions), Section 7.1
(Term), this Section 7.4 (Survival), Section 8 (Confidentiality), Section 12
(Indemnity), Section 13 (Limitation of Liability), Section 14 (Warranties) and
Section 15 (Miscellaneous) hereof shall survive any expiration or termination of
this Agreement in accordance with their terms.

8.      Confidentiality.

        8.1    Subject Information. UCHC and Licensee shall keep any technology,
formula, trade secrets, technical data or business information ("Information")
provided or made available by or otherwise obtained from the other Party or its
Affiliates hereunder confidential. Neither UCHC nor Licensee shall, without the
prior written consent of the other Party or its Affiliates, as the case may be,
use (except as expressly permitted by this Agreement), or disclose to any third
party, any Information provided or made available by the other Party or its
Affiliates hereunder; provided, however, that the foregoing shall not apply to
information which the Party receiving such information can establish by written
documentation to: (a) have been publicly known at the time of disclosure by the
other Party or its Affiliates, as the case may be, (b) have become publicly
known, without fault on its part, subsequent to such disclosure, (c) have been
otherwise obtained without restriction from a source (other than the other Party
or its agents or Affiliates), lawfully having the right to disclose such
information, or (d) have been developed by it or its Affiliates independently
without use of or reference to the Information as disclosed hereunder by the
other Party or its Affiliates.

        8.2    Permitted Disclosures. The foregoing shall not preclude the
disclosure of information by UCHC or Licensee:

               (a)    to its legal representatives, Affiliates, consultants,
outside contractors and (if it has the right to grant the license or sublicense)
its Licensees and sublicensees, under [like][written] confidentiality
obligations on the part of the recipients which obligations are equivalent to
Section 8 (Confidentiality) of this Agreement,

               (b)    to the extent required by law or regulation, provided
that, to the extent reasonably possible, it shall give prompt written notice of
the proposed disclosure to the other Party or its Affiliates, as the case may
be, so as to allow the other Party or its Affiliates, as the

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case may be, an opportunity to object to such requirement and, if applicable,
assure that confidential treatment will be accorded to such information, or

               (c)    to the extent that such information is reasonably required
to be disclosed for the purpose of securing necessary governmental authorization
for the clinical testing or marketing of products or for the purpose of
conducting clinical testing or marketing of products, or of prosecuting or
defending litigation.

        8.3    Terms of Agreement. The terms of this Agreement shall not be
disclosed by either Party to any third party (other than as provided in
Subsections 8.1(a), (b) and (c) above) or be published unless both Parties
expressly agree otherwise in writing. Furthermore, neither Party shall use the
name of the other Party or its Affiliates without their prior written consent.
However, the foregoing restrictions shall not apply to the disclosure of
information set forth in the form of an agreed-upon press release, if any, which
may be prepared in mutually agreeable format and substance for release on or
after the Effective Date, or to disclosures required by law or regulation. Both
UCHC and Licensee may include the existence of this Agreement and the Research
Agreement in annual reports and other public documents without the permission of
the other Party.

        8.4    Publication of UCHC Technology. Licensee shall not disclose any
unpublished UCHC Technology furnished by UCHC pursuant to this Agreement to
third parties during the term of this Agreement or any time thereafter,
provided, however, that Licensee may disclose any such UCHC Technology at any
time (in addition to the provisions of Section 8.1(a)-(d) above): (a) with the
prior written consent of Dr. Sarfarazi or UCHC, (b) after the same shall have
become public through no fault of Licensee; or (b) to sublicensees of Licensee
or other persons or entities with whom Licensee proposes to enter into a
business relationship, provided that such sublicensee or third party enters into
a confidentiality agreement containing provisions equivalent to Section 8
(Confidentiality) of this Agreement. The Licensee will not disclose proprietary
information which is unpublished and not included in a patent application
without Dr. Sarfarazi's prior permission, which shall not be unreasonably
withheld or delayed.

9.      Use of UCHC's Name.

        Licensee shall not use the name of UCHC or Dr. Sarfarazi or its then
current employees in advertising or promoting the sale of Licensed Products or
for any other business purpose without the prior written consent of UCHC and/ or
Dr. Sarfarazi, as appropriate.

10.     UCHC Use.

        It is expressly agreed that, notwithstanding any provisions herein, UCHC
is free to use the UCHC Technology and the Patent Rights for its own internal
research( basic and clinical), teaching and educational purposes without
limitation and without payment of royalties or any other form of payment.

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11.     Patent Rights.

        11.1   Patent Rights Control. During the term of this Agreement, filing
for, prosecuting and maintaining patent applications and patents included within
the Patent Rights shall be made at the discretion of and in the name of UCHC.
Licensee and its sublicensees shall have the opportunity to provide input on the
strategy for seeking such patent protection, including a reasonable opportunity
to review future patent applications and related documents associated with the
Patent Rights. Licensee shall cooperate with and assist UCHC in filing for and
prosecution of such Patent Rights. UCHC shall keep Licensee fully informed as to
the status of such Patent Rights. In addition, UCHC will use diligent efforts to
advise Licensee of all proposed patent filings of a substantive nature in time
reasonably sufficient for Licensee to review such filings.

        11.2   Patent Rights Costs. Licensee will reimburse UCHC for reasonable,
documented costs incurred by UCHC in the preparation, filing, prosecution and
maintenance of the Patent Rights. Unless otherwise agreed by the Parties in
writing, the law firm of Hamilton, Brook, Smith and Reynolds shall be utilized
for purposes of preparing, filing, prosecuting, and maintaining patent
applications hereunder.

        11.3   Patent Rights Transfer. If UCHC elects to terminate either the
prosecution or maintenance of the Patent Rights in any country prior to the
completion of normal prosecution before the patent examiner of such country or
prior to the end of the corresponding term for maintenance, as the case may be,
it will give Licensee sixty (60) days prior written notice of such election
prior to any time limit on any action due. Licensee, upon receipt of such
notice, shall have the option to undertake the continuation of such prosecution
or maintenance and UCHC will transfer title to Licensee for such patent
application or patent.

        11.4   Patent Rights Infringement Notice. Each Party shall promptly
inform the other Party of any actual, suspected or threatened infringement of
any Patent Rights by a third party or claim or action (including, without
limitation, any declaratory judgement) seeking a judgement of invalidity or
non-infringement with respect to any of the Patent Rights. With respect to each
such infringement, claim or action that may arise:

               (a)    Licensee shall have the initial right (but not the
obligation) to enforce the Patent Rights exclusively licensed hereunder or
defend any declaratory judgment action with respect thereto (collectively, an
"Enforcement Action") in its own name and at its expense.

               (b)    If Licensee has notified UCHC in writing that it elects
not to initiate an Enforcement Action, and if the licenses granted hereunder
become non-exclusive, pursuant to Section 3.4 (Payment Remedies), then UCHC
shall have the right (but not the obligation) to initiate an Enforcement Action
in its name and at its expense.

                                       10
<PAGE>

               (c)    The Party which does not initiate an Enforcement Action
may participate in such Enforcement Action with counsel of its own choosing. If
such Party chooses not to participate in such Enforcement Action, such Party
shall nonetheless reasonably cooperate, at the other Party's expense, in such
Enforcement Action including, without limitation, by agreeing, to the extent it
is legally able to do so, to be joined to such action.

               (d)    The monetary recovery in any Enforcement Action, including
any settlement amounts or court awarded damages shall be (i) applied first to
reimburse the initiating Party for any costs and fees (including attorneys' and
professional fees) incurred in connection with such Enforcement Action, and (ii)
thereafter allocated between the Parties pro-rata in accordance with the
relative damages, if any, suffered by each Party as the result of the subject
infringement, claim or action. Any amounts received by Licensee pursuant to
clause (ii) above, shall constitute revenue for Licensed Products subject to
royalty and sublicense fees, as applicable, under Section 3 (License Fees and
Royalties).

12.     Indemnity.

        12.1   Indemnification by Licensee. Licensee agrees to indemnify, hold
harmless and defend UCHC, its officers, employees, and agents, against any and
all claims, suits, damage, costs, fees, and expenses asserted by third parties,
both government and private, for death, illness, personal injury and property
damage resulting from or arising out of Licensee's development, use or sale of
the Licensed Products; provided that Licensee shall not be responsible for
amounts paid in settlement of any claim without its approval.

        12.2   Losses Resulting from UCHC: In the event of loss resulting from
acts of omission or commission by UCHC and/ or its employees in connection with
this Agreement, the Licensee or any third party shall have recourse through the
Connecticut Claims Commission as provided under Chapter 53 of the Statutes of
the State of Connecticut in which all claims against the State of Connecticut
and the University of Connecticut shall be filed with the State of Connecticut
Claims Commissioner. In addition, this provision shall apply to any claims
against UCHC made in conjunction with Section 15.2 (Governing Law and Dispute
Resolution) of this Agreement.

13.     LIMITATION OF LIABILITY.

        IN NO EVENT SHALL EITHER PARTY HAVE ANY LIABILITY FOR: ANY SPECIAL,
INDIRECT OR CONSEQUENTIAL DAMAGES INCLUDING, WITHOUT LIMITATION, DAMAGES FOR
LOST PROFITS, LOSS OF DATA OR COSTS OF PROCUREMENT OF SUBSTITUTE GOODS OR
SERVICES. THE FOREGOING SHALL APPLY TO LIABILITIES ARISING IN ANY WAY OUT OF
THIS AGREEMENT UNDER ANY CAUSE OF ACTION, WHETHER OR NOT SUCH PARTY HAS BEEN
ADVISED OF THE POSSIBILITY OF SUCH DAMAGES AND NOTWITHSTANDING THE FAILURE OF
THE ESSENTIAL PURPOSE OF ANY LIMITED REMEDY.

14.     Warranties.

                                       11
<PAGE>

        UCHC warrants that it: has the lawful right to grant the licenses
provided in this Agreement; has not granted rights or licenses in conflict with
this Agreement; has not received any notice of a claim of infringement or
misappropriation of any alleged rights asserted by any third party in relation
to the UCHC Technology or the Patent Rights; is not aware that any third party
is infringing the Patent Rights; and, except as disclosed to Licensee, UCHC is
not aware of any patents or other proprietary rights of any third party which
would materially affect the exercise of the license rights granted hereunder to
Licensee. UCHC covenants that during the term of this Agreement (or any license
granted hereunder), UCHC shall not enter into any other agreements that conflict
with rights or obligations provided hereunder, including any rights and
obligations that survive termination hereof.

15.     Miscellaneous.

        15.1   Notices. Any notice required or permitted to be given to the
Parties shall be deemed to have been properly given if delivered in person or
when received if mailed by first-class certified mail to the other Party at the
appropriate address as set forth at the beginning of this Agreement, or to such
other addresses as may be designated in writing by the Parties from time to time
during the term of this Agreement.

        15.2   Governing Law and Dispute Resolution. This Agreement shall be
governed by and construed in accordance with the laws of the State of
Connecticut without regard to the conflict of laws provisions thereof. Any
controversy arising under or related to this Agreement, or any disputed claim by
either Party against the other under this Agreement, excluding any dispute
between the Parties relating to patent validity or infringement arising under
this Agreement, shall be first addressed by good faith negotiation between the
Parties; if such efforts fail to resolve the dispute, the Parties shall seek the
assistance of a mutually acceptable third-party mediator. Notwithstanding
anything to the contrary, nothing in this Agreement shall be deemed as
preventing either Party from seeking injunctive relief or any other provisional
remedy from any court having jurisdiction over the Parties and the subject
matter of the dispute as necessary to protect either Party's name, proprietary
information, trade secrets, know-how or any other proprietary rights.

        15.3   Waiver. It is agreed that no waiver by either Party hereto of any
breach or default of any of the covenants or agreements herein set forth shall
be deemed a waiver as to any subsequent and/ or similar breach or default.

        15.4   Assignment. This Agreement shall not be assignable by either
Party without the written consent of the other Party, which consent shall not be
withheld or delayed unreasonably. Notwithstanding the foregoing, either Party
may transfer and assign this Agreement, without the other Party's consent, to an
entity that succeeds to substantially all of the business or assets of such
Party to which this Agreement pertains.

        15.5   Independent Contractors. The relationship of UCHC and Licensee
established by this Agreement is that of independent contractors, and nothing
contained in this Agreement shall

                                       12
<PAGE>

be construed: (a) to give either Party the power to direct or control the
day-to-day activities of the other; or (b) to constitute the Parties as
partners, joint venturers, co-owners or otherwise as participants in a joint or
common undertaking.

        15.6   Severability. If any provision of this Agreement is held to be
invalid by a court of competent jurisdiction, then the remaining provisions
shall nevertheless remain in full force and effect. The Parties further agree to
negotiate in good faith a substitute, valid and enforceable provision that most
nearly effects the Parties' intent and to be bound by the mutually agreed
substitute provision.

        15.7   Force Majeure. Nonperformance of either Party shall be excused to
the extent that performance is rendered impossible by strike, power failure or
shortage, earthquake, fire, flood, governmental acts or orders or restrictions,
failure of suppliers, acts of God or any other reason where failure to perform
is beyond the reasonable control and not caused by the negligence of the
non-performing Party.

        15.8   Entire Agreement. This Agreement constitutes the entire, final,
complete and exclusive agreement between the Parties and supersedes all previous
agreements or representations, oral or written, relating to the licensing and
commercial development of the POAG technology for prognostic and diagnostic use.
This Agreement may not be modified or amended except in a writing signed by a
duly authorized representative of each Party. Both Parties acknowledge having
read the terms and conditions set forth in this Agreement, understand all terms
and conditions, and agree to be bound thereby.

        15.9   Authorization to Contract. UCHC represents to Licensee that UCHC
is authorized to enter into this Agreement under Section 10a-104 and Sections
10a-110 to 10a-110g of the General Statutes of Connecticut, as amended as of the
Effective Date.

        IN WITNESS WHEREOF, the Parties have caused this Agreement to be
executed by their duly authorized representatives as of the day and year first
above written.

THE UNIVERSITY OF CONNECTICUT                INSITE VISION INCORPORATED
HEALTH CENTER

By:   /s/ Michael F. Newborg                 By:  /s/ Kumar Chandrasekaran
    -----------------------------------          ------------------------------
Name:  Michael F. Newborg                    Name:  Kumar Chandrasekaran
    -----------------------------------          ------------------------------
Title: Executive Dir.,                       Title: Chief Executive Officer
       Ctr.for Sci. & Tech. Comm'n.
       --------------------------------            ----------------------------
Date:                                        Date:  December 21, 2001
       --------------------------------            ----------------------------

                                       13

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