Document:

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                      FIRST AMENDMENT TO LICENSE AGREEMENT

      This First Amendment ("Amendment"), effective as of October 23, 1997, is
made to a certain License Agreement ("Agreement") by and between:

     MICRODROP GMBH, Muehlenweg 143, D-22844 Norderstedt, Germany (hereinafter
referred to as "Microdrop")

                                       and

     PACKARD INSTRUMENT COMPANY, INC., a State of Delaware corporation having
its principal office at 800 Research Parkway, Meriden, Connecticut 06450, USA
(hereinafter referred to as "Packard").

                              W I T N E S S E T H:

     WHEREAS, Microdrop and Packard entered into the Agreement as of March 26,
1996;

     WHEREAS, Microdrop and Packard desire to amend the terms of the Agreement
as set forth in this Amendment;

      NOW THEREFORE, in consideration of the premises and of the mutual
agreements and covenants herein contained, the parties hereto agree as follows:

1. Article IV of the Agreement (entitled "Exclusive License") is hereby amended
by changing the heading to read "Exclusive Licenses" and by adding to Article IV
the following new Article 4.2:

4.2 Microdrop hereby grants to Packard an exclusive, worldwide, paid up license
to use Licensed Microdrop Technology to make, have made and sell Microdrop
Products for the Field of Use. Said license shall include the right of Packard
to sublicense its Affiliates to distribute Microdrop Products.

2.   The following new Article 4.3 is hereby added immediately following Article
4.2:

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      4.3 In order to implement the license granted under Article 4.2 hereof,
Microdrop will use its best efforts to transfer all Microdrop Technology and
Technical Information and all existing raw material resources to Packard under
the following terms and conditions:

      4.3.1 Microdrop and Packard have jointly evaluated how to transfer
efficiently Technical Information, manufacturing know-how and raw material
resources and both parties agree upon the detailed plan and schedule for the
transfer of the manufacturing technology and know-how attached as SCHEDULE 1 to
this Amendment.

      4.3.2 Microdrop agrees to make the necessary resources available to
accomplish the transfer of Microdrop Technology and Technical Information
hereunder. To this end, Microdrop agrees to supply Packard with drawings and
technical information, including to the extent available, all drawings necessary
for production of the Microdrop Products, including drawings of each part,
drawings of assembled products, and drawings of jigs, tools, production, testing
and inspection apparatus; data necessary for working, including processes,
suppliers, subcontractors, bills of material, working hours, and tolerances.

      4.3.3 Microdrop grants to Packard permission at any time to send, at
Packard's expense and after prior verbal agreement from Microdrop on the dates,
a reasonable number of engineers for a reasonable time, to Microdrop's facility
to obtain any instructions or information which Packard may reasonably require
to manufacture the Microdrop Products. More specifically, Microdrop and Packard
agree to jointly develop in Microdrop's facility, production equipment for the
manufacturing of the Microdrop Products, and to transfer this equipment to
Packard's production facility in Downers Grove, Illinois, U.S.A., as soon as it
is ready for routine production of the Microdrop Products. At Packard's request
and expense, Microdrop agrees to send a reasonable number of engineers for a
reasonable time to Packard's Downers Grove facility to help with production
startup.

      4.3.4 Until Packard is able to manufacture and supply the demand for
Microdrop Products, Microdrop agrees to manufacture, sell and deliver to Packard
Microdrop Products in accordance with the terms and conditions of Paragraph 3 of
the License Agreement.

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      4.3.5 In the event that any improvement of the Microdrop Product, in
relation to manufacturing or use, is made by either of the parties, Technical
Information with respect thereto will be furnished to the other party without
payment. These improvements can be used by either party in their respective
Fields of Use.

      4.3.6 Microdrop agrees to function as a second supply source to Packard of
Microdrop Products. Microdrop shall sell and deliver to Packard such
second-sourced Microdrop Products under the terms and conditions defined in
paragraph 3 of the Agreement.

      4.3.7 Microdrop agrees to deliver to Packard, [* * *] Microdrop
Products as specified in the attached purchase order (EXHIBIT 1), at the
price of [* * *], and at the delivery rate detailed in EXHIBIT 1.

      4.3.8 In addition to the confidentiality terms set forth in the Agreement,
Packard agrees to keep all technical information, drawings, specifications,
manufacturing instructions, and other information relating to the production of
Microdrop Products strictly confidential. Packard will not communicate, without
first obtaining the written consent of Microdrop, the same to anyone except to
its employees and subcontractors, and to the extent necessary for the proper
production of Microdrop Products in accordance with the provisions of this
Amendment.

3.    Article 5.1(c) is hereby amended to read as follows:

      (c) Running royalties during the term of this Agreement (including any
extensions) at the rate of (i) [* * *] of Net Sales by Packard of Licensed
Packard Products containing Microdrop Products manufactured by Microdrop,
(ii) [* * *] of Net Sales by Packard of Licensed Packard Products containing
Microdrop Products manufactured by Packard, and (iii) [* * *] of Net Sales by
Packard of Microdrop Products manufactured pursuant to the license granted in
Article 4.2 and not incorporated in a Licensed Packard Product.

4.    Article 5.2 is hereby amended by adding "and Microdrop Products"
immediately following Licensed Packard Products" in the two places where
"Licensed Packard Products" appears therein.

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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5.    Article 5.3 is hereby amended by adding "or Microdrop Products"
immediately following "Licensed Packard Products" where it appears therein.

6.    The following new Article 5.5 is hereby added to the Agreement immediately
following Article 5.4:

      5.5 In consideration of the exclusive license granted pursuant to
Article 4.2 thereof and the transfer of the technical know-how, Packard
agrees to pay Microdrop [***], in addition to the payments set forth in
paragraph 5 of the Agreement. Said sum of [* * *] will be payable as follows:

            (a) [* * *] upon signing of a letter of intent relating to this
            Amendment, receipt of which amount is hereby acknowledged by
            Microdrop.

            (b) [* * *] upon signing of this Amendment.

            (c) [* * *] after successful transfer of the production to Packard,
            payable as follows:

                  (1) [* * *] upon production of the first functional Microdrop
                  Product on Microdrop's new production line apparatus which
                  will be jointly developed by Packard and Microdrop as outlined
                  in Article 4.3.3 of this Amendment, no later than May 31,
                  1997; provided that if such production is delayed after May
                  31, 1997, the [* * *] payment shall be reduced by [* * *]
                  for each week of such delay.

                  (2) [* * *] upon production of the first forty (40)
                  functional Microdrop Products on the routine production line
                  transferred from Microdrop to Packard's facility in Downers
                  Grove, and the completion of all technology transfer
                  information and data, no later than July 31, 1997; provided
                  that if such production is delayed after July 31, 1997, the
                  [* * *] payment shall be reduced by [* * *] for
                  each week of such delay.

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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            (d) [* * *] upon the sale by Packard of the 100th Licensed Packard
            Product, provided that the sale is realized within a [* * *]
            maximum period after delivery of the first Licensed Packard Product
            which incorporates multiple Microdrop Products.

            (e) [* * *] upon the sale of the 250th Licensed Packard Product
            provided that the sale is made within a [* * *] maximum period
            after delivery of the first Licensed Packard Product which
            incorporate multiple Microdrop Products.

            5.6 In addition, Packard shall pay Microdrop [* * *] for the
            development of a production line at Microdrop, transferable to
            Packard, for the routine production of Microdrop Products. This
            amount will be paid upon the completion of the transfer of the
            product line to Packard in Downers Grove.

7.    Article 3.5 is hereby amended to read in its entirety as follows:

      3.5 Microdrop shall refer to Packard all potential sales of Microdrop
Products within the Field of Use, and all inquiries from customers or
potential customers for Microdrop Products, worldwide within the Field of
Use. If Packard is unable to meet the needs of a customer, Packard may, in
its sole discretion, but shall not be required hereby to, request Microdrop
to fill the order from such customer that is not filled by Packard. Except
for the orders listed on SCHEDULE 2 hereto, which shall be filled by
Microdrop, Microdrop agrees to cancel all existing orders in the Field of Use
on the date of this Amendment and to refer such customers to Packard. Packard
shall pay Microdrop the sum of [* * *] in consideration of Microdrop's loss of
business opportunity hereunder. Within the Field of Use, the acceptance of
any new orders, and all decisions to, with respect to the supply of,
Microdrop Products and Licensed Packard Products, both to fill new orders and
for service and support of existing customers, shall be at the sole
discretion of Packard. Microdrop agrees to cooperate with and assist Packard
in seeking to convert Microdrop existing customer, [* * *] to the use of
Licensed Packard Products. If Packard determines that it is unable to deliver
to [* * *] Microdrop Products with the required specifications such as those
detailed in EXHIBIT 2, Packard agrees that Microdrop may deliver custom-built

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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Microdrop Products directly to [* * *] for its sole use in manufacturing
diagnostic tests.

      IN WITNESS WHEREOF, the undersigned parties, acting through their duly
authorized representatives, have executed this Agreement in multiple
counterparts.

MICRODROP, GmbH

By: /s/ Michael Doering
   -------------------------------
Name: Michael Doering
     -----------------------------
Title: Managing Director
      ----------------------------
Date: September 30, 1997
     -----------------------------

PACKARD INSTRUMENT COMPANY, INC.

By: /s/ Richard T. McKernan
   --------------------------------
Name: Richard T. McKernan
     ------------------------------
Title: Managing Director
      -----------------------------
Date: October 23, 1997
     ------------------------------

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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                      SECOND AMENDMENT TO LICENSE AGREEMENT

      This Second Amendment ("Amendment"), effective as of March __, 1999, is
made to a certain License Agreement by and between:

      MICRODROP GMBH, Muehlenweg 143, D-22844 Norderstedt, Germany
(hereinafter referred to as "Microdrop")

                                       and

      PACKARD INSTRUMENT COMPANY, INC., a State of Delaware corporation
having its principal office at 800 Research Parkway, Meriden, Connecticut
06450, USA (hereinafter referred to as "Packard").

                             W I T N E S S E T H:

      WHEREAS, Microdrop and Packard entered into a License Agreement as of May
26, 1996, which was amended by the First Amendment to the Agreement effective as
of October 23, 1997 (collectively, the "Agreement");

      WHEREAS, Microdrop and Packard desire to amend the terms of the
Agreement as set forth in this Amendment;

      NOW THEREFORE, in consideration of the premises and of the mutual
agreements and covenants herein contained, the parties hereto agree as follows:

1.    Article 5.5(d) is deleted in its entirety and the following is
substituted therefor:

            (d) [* * *] upon the sale by Packard of the 100th Licensed
            Packard Product.

2.    Article 5.5(e) is deleted in its entirety and the following is
substituted therefor:

            (e) [* * *] upon the sale by Packard of the 250th Licensed
            Packard Product.

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

<PAGE>

3. The following new Article 5.7 and Article 5.8 are hereby added to the
Agreement immediately following Article 5.6:

            5.7 Microdrop shall use commercially reasonable efforts to achieve,
            in accordance with the schedule set forth in Appendix 1 to this
            Agreement, the objectives of the research and development program as
            described in Appendix 1 to this Agreement (the "Development
            Program"). Packard shall compensate Microdrop for the Development
            Program in the amounts set forth below, and in accordance with the
            completion of the following milestones:

                  a.    [* * *] upon execution and delivery of the Second
                  Amendment to the Agreement.

                  b.    [* * *] upon delivery of the Phase 1 Deliverables (as
                  defined in Appendix 1) in form and substance reasonably
                  acceptable to Packard.

                  c.    [* * *] upon delivery of the Phase 2 Deliverables (as
                  defined in Appendix 1) in form and substance reasonably
                  acceptable to Packard.

                  d.    [* * *] upon delivery of the Phase 3 Deliverables (as
                  defined in Appendix 1) in form and substance reasonably
                  acceptable to Packard.

                  The Development Program will be carried out primarily at
            Microdrop's facility. Microdrop grants to Packard permission at any
            time to send, at Packard's expense and after prior verbal agreement
            from Microdrop on the dates, a reasonable number of engineers for a
            reasonable time, to Microdrop's facility to observe and participate
            in the Development Program. Microdrop agrees to make the necessary
            resources available to accomplish the transfer to Packard of
            Microdrop Technology and Technical Information derived from or
            relating to the Development Program. At Packard's request and
            expense, Microdrop agrees to send a reasonable number of engineers
            for a reasonable time to Packard's production facility in Downers
            Grove, Illinois, U.S.A. or elsewhere to facilitate such transfer of
            Microdrop Technology and Technical Information. No milestone
            described above shall be deemed completed until Microdrop has
            transferred to

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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            Packard all relevant Microdrop Technology and Technical
            Information relating to the deliverables for a specified
            milestone, in a form and substance reasonably satisfactory to
            Packard.

            5.8 In addition to the payment of running royalties as set forth in
            Article 5.1(c), Packard shall pay to Microdrop [* * *] of Net
            Sales by Packard of Licensed Packard Products for all sales of
            Licensed Packard Products realized on or prior to [* * *]. For
            purposes of determining the minimum royalty payments described in
            Article 5.4, payments made by Packard pursuant to this Article 5.8
            shall not be included as part of the calculation of "aggregate
            royalties accrued under Article 5.1."

4.    The following new Article 3.6 is hereby added to the Agreement
immediately following Article 3.5:

      3.6 Notwithstanding anything to the contrary in this Agreement, until
      November 30, 1999 (the "Microdrop Sales Termination Date"), Microdrop
      reserves the right to sell Microdrop Products equipped with dispensing
      heads containing up to four piezo tips for use within the Field of Use
      directly to customers that are end users of the Microdrop Products;
      provided that Microdrop shall, at least twenty (20) days prior to making
      any such sale, notify Packard in writing of the intended sale and seek
      Packard's prior written consent, which consent shall not be withheld
      unreasonably. After the Microdrop Sales Termination Date, Microdrop shall
      refer to Packard all potential sales of Microdrop Products, and all
      inquiries from customers or potential customers for Microdrop Products,
      worldwide within the Field of Use as provided in Article 3.5 above;
      provided, however, Microdrop shall be permitted to (i) fulfill all orders
      from customers accepted by Microdrop on or prior to the Microdrop Sales
      Termination Date in accordance with this Article 3.6 and (ii) deliver to
      any end user of a Microdrop Product sold in accordance with this Article
      3.6 such spare parts as are reasonably necessary to the continued
      operation by such end user of the Microdrop Product, so long as such
      Microdrop Product continues to be equipped only with dispensing heads
      containing four or fewer piezo tips.

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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      If Packard fails to realize the sale of its [* * *] Licensed Packard
      Product on or prior to November 30, 1999, the Microdrop Sales
      Termination Date shall be extended until November 30, 2000. If Packard
      fails to realize the sale of its [* * *] Licensed Packard Product on or
      prior to November 30, 2000, the Microdrop Sales Termination Date shall
      be extended until such time as Packard realizes the sale of its [* * *]
      Licensed Packard Product, and Microdrop shall no longer be required to
      provide notice of any sale or request the prior consent of Packard to
      consummate any sale until the occurrence of the Microdrop Sales
      Termination Date.

      IN WITNESS WHEREOF, the undersigned parties, acting through their duly
authorized representatives, have executed this Amendment in multiple
counterparts.

MICRODROP, GmbH

By: /s/ Wilhelm Mayer
   -------------------------------
Name: Wilhelm Mayer
     -----------------------------
Title: Managing Director
      ----------------------------
Date: 10/5/99
     -----------------------------

PACKARD INSTRUMENT COMPANY, INC.

By: /s/ Richard T. McKernan
   -------------------------------
Name: Richard T. McKernan
     -----------------------------
Title: President
      ----------------------------

Date: 4/14/1999
     -----------------------------

[* * *] Indicates information omitted pursuant to a request for confidential
treatment and filed separately with the Securities and Exchange Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934,
as amended.

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