Document:

EX-10.52

Exhibit 10.52

DIRECTOR INDEMNIFICATION AGREEMENT

          THIS INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of March 3, 2009
between Specialty Underwriters’ Alliance, Inc., a Delaware corporation (the “Company”), and [          ] (“Indemnitee”).

     WITNESSETH THAT:

     WHEREAS, highly competent persons have become more reluctant to serve corporations as
directors or in other capacities unless they are provided with adequate protection through
insurance or adequate indemnification against inordinate risks of claims and actions against them
arising out of their service to and activities on behalf of the corporation;

     WHEREAS, the Board of Directors of the Company (the “Board”) has determined that, in order to
attract and retain qualified individuals, the Company will attempt to maintain on an ongoing basis,
at its sole expense, liability insurance to protect persons serving the Company and its
subsidiaries from certain liabilities. Although the furnishing of such insurance has been a
customary and widespread practice among United States-based corporations and other business
enterprises, the Company believes that, given current market conditions and trends, such insurance
may be available to it in the future only at higher premiums and with more exclusions. At the same
time, directors, officers, and other persons in service to corporations or business enterprises are
being increasingly subjected to expensive and time-consuming litigation relating to, among other
things, matters that traditionally would have been brought only against the Company or business
enterprise itself. The By-laws of the Company require indemnification of the directors of the
Company. Indemnitee may also be entitled to indemnification pursuant to the General Corporation
Law of the State of Delaware (“DGCL”). The By-laws and the DGCL expressly provide that the
indemnification provisions set forth therein are not exclusive, and thereby contemplate that
contracts may be entered into between the Company and members of the board of directors, officers
and other persons with respect to indemnification;

     WHEREAS, the uncertainties relating to such insurance and to indemnification have increased
the difficulty of attracting and retaining such persons;

     WHEREAS, the Board has determined that the increased difficulty in attracting and retaining
such persons is detrimental to the best interests of the Company’s stockholders and that the
Company should act to assure such persons that there will be increased certainty of such protection
in the future;

     WHEREAS, it is reasonable, prudent and necessary for the Company contractually to obligate
itself to indemnify, and to advance expenses on behalf of, such persons to the fullest extent
permitted by applicable law so that they will serve or continue to serve the Company free from
undue concern that they will not be so indemnified;

     WHEREAS, this Agreement is a supplement to and in furtherance of the By-laws of the Company
and any resolutions adopted pursuant thereto, and shall not be deemed a substitute therefor, nor to
diminish or abrogate any rights of Indemnitee thereunder;

 

 

     WHEREAS, Indemnitee does not regard the protection available under the Company’s By-laws and
insurance as adequate in the present circumstances, and may not be willing to serve as a director
without adequate protection, and the Company desires Indemnitee to serve in such capacity.
Indemnitee is willing to serve, continue to serve and to take on additional service for or on
behalf of the Company on the condition that he be so indemnified; and

     NOW, THEREFORE, in consideration of Indemnitee’s agreement to serve as a director after the
date hereof, the parties hereto agree as follows:

          1. Definitions. For purposes of this Agreement:

               (a) “Corporate Status” describes the status of a person who is or was a director, officer,
employee, agent or fiduciary of the Company or of any other corporation, partnership, joint
venture, trust, employee benefit plan or other enterprise that such person is or was serving at the
express written request of the Company.

               (b) “Disinterested Director” means a director of the Company who is not and was not a party to
the Proceeding in respect of which indemnification is sought by Indemnitee.

               (c) “Enterprise” shall mean the Company and any other corporation, partnership, joint venture,
trust, employee benefit plan or other enterprise that Indemnitee is or was serving at the express
written request of the Company as a director, officer, employee, agent or fiduciary.

               (d) “Expenses” shall include all reasonable attorneys’ fees, retainers, court costs,
transcript costs, fees of experts, witness fees, travel expenses, duplicating costs, printing and
binding costs, telephone charges, postage, delivery service fees and all other disbursements or
expenses of the types customarily incurred in connection with prosecuting, defending, preparing to
prosecute or defend, investigating, participating, or being or preparing to be a witness in a
Proceeding. Expenses also shall include Expenses incurred in connection with any appeal resulting
from any Proceeding, including without limitation the premium, security for, and other costs
relating to any cost bond, supersede as bond, or other appeal bond or its equivalent. Expenses,
however, shall not include amounts paid in settlement by Indemnitee or the amount of judgments or
fines against Indemnitee.

               (e) “Independent Counsel” means a law firm, or a member of a law firm, that is experienced in
matters of corporation law and neither presently is, nor in the past five years has been, retained
to represent: (i) the Company or Indemnitee in any matter material to either such party (other
than with respect to matters concerning Indemnitee under this Agreement, or of other indemnitees
under similar indemnification agreements), or (ii) any other party to the Proceeding giving rise to
a claim for indemnification hereunder. Notwithstanding the foregoing, the term “Independent
Counsel” shall not include any person who, under the applicable standards of professional conduct
then prevailing, would have a conflict of interest in representing either the Company or Indemnitee
in an action to determine Indemnitee’s rights under this Agreement. The Company agrees to pay the
reasonable fees of the Independent Counsel referred to above and to fully indemnify such counsel
against any and all Expenses,

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claims, liabilities and damages arising out of or relating to this Agreement or its engagement
pursuant hereto.

               (f) “Proceeding” includes any threatened, pending or completed action, suit, arbitration,
alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or any other
actual, threatened or completed proceeding, whether brought by or in the right of the Company or
otherwise and whether civil, criminal, administrative or investigative, in which Indemnitee was, is
or will be involved as a party or otherwise, by reason of the fact that Indemnitee is or was an
officer or director of the Company, by reason of any action taken by him or of any inaction on his
part while acting as an officer or director of the Company, or by reason of the fact that he is or
was serving at the request of the Company as a director, officer, employee, agent or fiduciary of
another corporation, partnership, joint venture, trust or other Enterprise; in each case whether or
not he is acting or serving in any such capacity at the time any liability or expense is incurred
for which indemnification can be provided under this Agreement; including one pending on or before
the date of this Agreement, but excluding one initiated by an Indemnitee pursuant to Section
8 of this Agreement to enforce his rights under this Agreement.

          2. Indemnity of Indemnitee. The Company hereby agrees to hold harmless and indemnify
Indemnitee to the fullest extent permitted by law, as such may be amended from time to time. In
furtherance of the foregoing indemnification, and without limiting the generality thereof:

               (a) Proceedings Other Than Proceedings by or in the Right of the Company. Indemnitee
shall be entitled to the rights of indemnification provided in this Section 2(a) if, by
reason of his Corporate Status, the Indemnitee is, or is threatened to be made, a party to or
participant in any Proceeding other than a Proceeding by or in the right of the Company. Pursuant
to this Section 2(a), Indemnitee shall be indemnified against all Expenses, judgments,
penalties, fines and amounts paid in settlement actually and reasonably incurred by him, or on his
behalf, in connection with such Proceeding or any claim, issue or matter therein, if the Indemnitee
acted in good faith and in a manner the Indemnitee reasonably believed to be in or not opposed to
the best interests of the Company, and with respect to any criminal Proceeding, had no reasonable
cause to believe the Indemnitee’s conduct was unlawful.

               (b) Proceedings by or in the Right of the Company. Indemnitee shall be entitled to
the rights of indemnification provided in this Section 2(b) if, by reason of his Corporate
Status, the Indemnitee is, or is threatened to be made, a party to or participant in any Proceeding
brought by or in the right of the Company. Pursuant to this Section 2(b), Indemnitee shall
be indemnified against all Expenses actually and reasonably incurred by the Indemnitee, or on the
Indemnitee’s behalf, in connection with such Proceeding if the Indemnitee acted in good faith and
in a manner the Indemnitee reasonably believed to be in or not opposed to the best interests of the
Company; provided, however, if applicable law so provides, no indemnification against such Expenses
shall be made in respect of any claim, issue or matter in such Proceeding as to which Indemnitee
shall have been adjudged to be liable to the Company unless and to the extent that the Court of
Chancery of the State of Delaware (the “Delaware Court”) shall determine that such indemnification
may be made.

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               (c) Indemnification for Expenses of a Party Who is Wholly or Partly Successful.
Notwithstanding any other provision of this Agreement, to the extent that Indemnitee is, by reason
of his Corporate Status, a party to and is successful, on the merits or otherwise, in any
Proceeding, he shall be indemnified to the maximum extent permitted by law, as such may be amended
from time to time, against all Expenses actually and reasonably incurred by him or on his behalf in
connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful,
on the merits or otherwise, as to one or more but less than all claims, issues or matters in such
Proceeding, the Company shall indemnify Indemnitee against all Expenses actually and reasonably
incurred by him or on his behalf in connection with each successfully resolved claim, issue or
matter. For purposes of this Section and without limitation, the termination of any claim, issue
or matter in such a Proceeding by dismissal, with or without prejudice, shall be deemed to be a
successful result as to such claim, issue or matter.

          3. Additional Indemnity. In addition to, and without regard to any limitations on,
the indemnification provided for in Section 2 of this Agreement, the Company shall and
hereby does indemnify and hold harmless Indemnitee against all Expenses, judgments, penalties,
fines and amounts paid in settlement actually and reasonably incurred by him or on his behalf if,
by reason of his Corporate Status, he is, or is threatened to be made, a party to or participant in
any Proceeding (including a Proceeding by or in the right of the Company), including, without
limitation, all liability arising out of the negligence or active or passive wrongdoing of
Indemnitee. The only limitation that shall exist upon the Company’s obligations pursuant to this
Agreement shall be that the Company shall not be obligated to make any payment to Indemnitee that
is finally determined (under the procedures, and subject to the presumptions, set forth in
Sections 7 and 8 hereof) to be unlawful.

          4. Contribution.

               (a) Whether or not the indemnification provided in Sections 2 and 3 hereof is
available, in respect of any threatened, pending or completed action, suit or proceeding in which
the Company is jointly liable with Indemnitee (or would be if joined in such action, suit or
proceeding), the Company shall pay, in the first instance, the entire amount of any judgment or
settlement of such action, suit or proceeding without requiring Indemnitee to contribute to such
payment and the Company hereby waives and relinquishes any right of contribution it may have
against Indemnitee. The Company shall not enter into any settlement of any action, suit or
proceeding in which the Company is jointly liable with Indemnitee (or would be if joined in such
action, suit or proceeding) unless such settlement provides for a full and final release of all
claims asserted against Indemnitee.

               (b) Without diminishing or impairing the obligations of the Company set forth in the preceding
subparagraph, if, for any reason, Indemnitee shall elect or be required to pay all or any portion
of any judgment or settlement in any threatened, pending or completed action, suit or proceeding in
which the Company is jointly liable with Indemnitee (or would be if joined in such action, suit or
proceeding), the Company shall contribute to the amount of expenses (including attorneys’ fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred and paid or
payable by Indemnitee in proportion to the relative benefits received by the Company and all
officers, directors or employees of the Company, other than Indemnitee, who are jointly liable with
Indemnitee (or would be if joined in such action, suit or

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proceeding), on the one hand, and Indemnitee, on the other hand, from the transaction from
which such action, suit or proceeding arose; provided, however, that the proportion determined on
the basis of relative benefit may, to the extent necessary to conform to law, be further adjusted
by reference to the relative fault of the Company and all officers, directors or employees of the
Company other than Indemnitee who are jointly liable with Indemnitee (or would be if joined in such
action, suit or proceeding), on the one hand, and Indemnitee, on the other hand, in connection with
the events that resulted in such expenses, judgments, fines or settlement amounts, as well as any
other equitable considerations which the law may require to be considered. The relative fault of
the Company and all officers, directors or employees of the Company, other than Indemnitee, who are
jointly liable with Indemnitee (or would be if joined in such action, suit or proceeding), on the
one hand, and Indemnitee, on the other hand, shall be determined by reference to, among other
things, the degree to which their actions were motivated by intent to gain personal profit or
advantage, the degree to which their liability is primary or secondary and the degree to which
their conduct is active or passive.

               (c) The Company hereby agrees to fully indemnify and hold Indemnitee harmless from any claims
of contribution which may be brought by officers, directors or employees of the Company, other than
Indemnitee, who may be jointly liable with Indemnitee.

               (d) To the fullest extent permissible under applicable law, if the indemnification provided
for in this Agreement is unavailable to Indemnitee for any reason whatsoever, the Company, in lieu
of indemnifying Indemnitee, shall contribute to the amount incurred by Indemnitee, whether for
judgments, fines, penalties, excise taxes, amounts paid or to be paid in settlement and/or for
Expenses, in connection with any claim relating to an indemnifiable event under this Agreement, in
such proportion as is deemed fair and reasonable in light of all of the circumstances of such
Proceeding in order to reflect (i) the relative benefits received by the Company and Indemnitee as
a result of the event(s) and/or transaction(s) giving cause to such Proceeding; and/or (ii) the
relative fault of the Company (and its directors, officers, employees and agents) and Indemnitee in
connection with such event(s) and/or transaction(s).

          5. Indemnification for Expenses of a Witness. Notwithstanding any other provision of
this Agreement, to the extent that Indemnitee is, by reason of his Corporate Status, a witness in
any Proceeding to which Indemnitee is not a party, he shall be indemnified against all Expenses
actually and reasonably incurred by him or on his behalf in connection therewith.

          6. Advancement of Expenses. Notwithstanding any other provision of this Agreement,
the Company shall advance all Expenses incurred by or on behalf of Indemnitee in connection with
any Proceeding by reason of Indemnitee’s Corporate Status within thirty (30) days after the receipt
by the Company of a statement or statements from Indemnitee requesting such advance or advances
from time to time, whether prior to or after final disposition of such Proceeding. Such statement
or statements shall reasonably evidence the Expenses incurred by Indemnitee and shall include or be
preceded or accompanied by an undertaking by or on behalf of Indemnitee to repay any Expenses
advanced if it shall ultimately be determined that Indemnitee is not entitled to be indemnified
against such Expenses. Any advances and undertakings to repay pursuant to this Section 6
shall be unsecured and interest free.

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          7. Procedures and Presumptions for Determination of Entitlement to Indemnification.
It is the intent of this Agreement to secure for Indemnitee rights of indemnity that are as
favorable as may be permitted under the DGCL and public policy of the State of Delaware.
Accordingly, the parties agree that the following procedures and presumptions shall apply in the
event of any question as to whether Indemnitee is entitled to indemnification under this Agreement:

               (a) To obtain indemnification under this Agreement, Indemnitee shall submit to the Company a
written request, including therein or therewith such documentation and information as is reasonably
available to Indemnitee and is reasonably necessary to determine whether and to what extent
Indemnitee is entitled to indemnification. The Secretary of the Company shall, promptly upon
receipt of such a request for indemnification, advise the Board in writing that Indemnitee has
requested indemnification.

               (b) Upon written request by Indemnitee for indemnification pursuant to the first sentence of
Section 7(a) hereof, a determination, if required by applicable law, with respect to
Indemnitee’s entitlement thereto shall be made in the specific case by one of the following four
methods, which shall be at the election of the board: (1) by a majority vote of the Disinterested
Directors, even though less than a quorum, by a committee of Disinterested Directors designated by
a majority vote of the Disinterested Directors, even though less than a quorum, (2) if there are no
Disinterested Directors or if the Disinterested Directors so direct, by independent legal counsel
in a written opinion to the Board, a copy of which shall be delivered to the Indemnitee, or (3) if
so directed by the Board, by the stockholders of the Company.

               (c) If the determination of entitlement to indemnification is to be made by Independent
Counsel pursuant to Section 7(b) hereof, the Independent Counsel shall be selected as
provided in this Section 7(c). The Independent Counsel shall be selected by the Board.
Indemnitee may, within 10 days after such written notice of selection shall have been given,
deliver to the Company, as the case may be, a written objection to such selection; provided,
however, that such objection may be asserted only on the ground that the Independent Counsel so
selected does not meet the requirements of “Independent Counsel” as defined in Section 1 of this
Agreement, and the objection shall set forth with particularity the factual basis of such
assertion. Absent a proper and timely objection, the person so selected shall act as Independent
Counsel. If a written objection is made and substantiated, the Independent Counsel selected may
not serve as Independent Counsel unless and until such objection is withdrawn or a court has
determined that such objection is without merit. If, within 20 days after submission by Indemnitee
of a written request for indemnification pursuant to Section 7(a) hereof, no Independent
Counsel shall have been selected and not objected to, either the Company or Indemnitee may petition
the Delaware Court or other court of competent jurisdiction for resolution of any objection which
shall have been made by the Indemnitee to the Company’s selection of Independent Counsel and/or for
the appointment as Independent Counsel of a person selected by the court or by such other person as
the court shall designate, and the person with respect to whom all objections are so resolved or
the person so appointed shall act as Independent Counsel under Section 7(b) hereof. The
Company shall pay any and all reasonable fees and expenses of Independent Counsel incurred by such
Independent Counsel in connection with acting pursuant to Section 7(b) hereof, and the
Company shall pay all reasonable fees and

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expenses incident to the procedures of this Section 7(c), regardless of the manner in
which such Independent Counsel was selected or appointed.

               (d) In making a determination with respect to entitlement to indemnification hereunder, the
person or persons or entity making such determination shall presume that Indemnitee is entitled to
indemnification under this Agreement. Anyone seeking to overcome this presumption shall have the
burden of proof and the burden of persuasion by clear and convincing evidence. Neither the failure
of the Company (including by its directors or independent legal counsel) to have made a
determination prior to the commencement of any action pursuant to this Agreement that
indemnification is proper in the circumstances because Indemnitee has met the applicable standard
of conduct, nor an actual determination by the Company (including by its directors or independent
legal counsel) that Indemnitee has not met such applicable standard of conduct, shall be a defense
to the action or create a presumption that Indemnitee has not met the applicable standard of
conduct.

               (e) Indemnitee shall be deemed to have acted in good faith if Indemnitee’s action is based on
the records or books of account of the Enterprise, including financial statements, or on
information supplied to Indemnitee by the officers of the Enterprise in the course of their duties,
or on the advice of legal counsel for the Enterprise or on information or records given or reports
made to the Enterprise by an independent certified public accountant or by an appraiser or other
expert selected with reasonable care by the Enterprise. In addition, the knowledge and/or actions,
or failure to act, of any director, officer, agent or employee of the Enterprise shall not be
imputed to Indemnitee for purposes of determining the right to indemnification under this
Agreement. Whether or not the foregoing provisions of this Section 7(e) are satisfied, it
shall in any event be presumed that Indemnitee has at all times acted in good faith and in a manner
he reasonably believed to be in or not opposed to the best interests of the Company. Anyone
seeking to overcome this presumption shall have the burden of proof and the burden of persuasion by
clear and convincing evidence.

               (f) If the person, persons or entity empowered or selected under Section 7 to
determine whether Indemnitee is entitled to indemnification shall not have made a determination
within sixty (60) days after receipt by the Company of the request therefor, the requisite
determination of entitlement to indemnification shall be deemed to have been made and Indemnitee
shall be entitled to such indemnification absent (i) a misstatement by Indemnitee of a material
fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially
misleading, in connection with the request for indemnification, or (ii) a prohibition of such
indemnification under applicable law; provided, however, that such 60-day period may be extended
for a reasonable time, not to exceed an additional thirty (30) days, if the person, persons or
entity making such determination with respect to entitlement to indemnification in good faith
requires such additional time to obtain or evaluate documentation and/or information relating
thereto; and provided, further, that the foregoing provisions of this Section 7(f) shall
not apply if the determination of entitlement to indemnification is to be made by the stockholders
pursuant to Section 7(b) of this Agreement and if (A) within fifteen (15) days after
receipt by the Company of the request for such determination, the Board or the Disinterested
Directors, if appropriate, resolve to submit such determination to the stockholders for their
consideration at an annual meeting thereof to be held within seventy-five (75) days after such
receipt and such determination is made thereat, or (B) a special meeting of stockholders is called
within fifteen

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(15) days after such receipt for the purpose of making such determination, such meeting is
held for such purpose within sixty (60) days after having been so called and such determination is
made thereat.

               (g) Indemnitee shall cooperate with the person, persons or entity making such determination
with respect to Indemnitee’s entitlement to indemnification, including providing to such person,
persons or entity upon reasonable advance request any documentation or information which is not
privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee
and reasonably necessary to such determination. Any Independent Counsel, member of the Board or
stockholder of the Company shall act reasonably and in good faith in making a determination
regarding the Indemnitee’s entitlement to indemnification under this Agreement. Any costs or
expenses (including attorneys’ fees and disbursements) incurred by Indemnitee in so cooperating
with the person, persons or entity making such determination shall be borne by the Company
(irrespective of the determination as to Indemnitee’s entitlement to indemnification) and the
Company hereby indemnifies and agrees to hold Indemnitee harmless therefrom.

               (h) The Company acknowledges that a settlement or other disposition short of final judgment
may be successful if it permits a party to avoid expense, delay, distraction, disruption and
uncertainty. In the event that any action, claim or proceeding to which Indemnitee is a party is
resolved in any manner other than by adverse judgment against Indemnitee (including, without
limitation, settlement of such action, claim or proceeding with or without payment of money or
other consideration) it shall be presumed that Indemnitee has been successful on the merits or
otherwise in such action, suit or proceeding. Anyone seeking to overcome this presumption shall
have the burden of proof and the burden of persuasion by clear and convincing evidence.

               (i) The termination of any Proceeding or of any claim, issue or matter therein, by judgment,
order, settlement or conviction, or upon a plea of nolo contendere or its equivalent, shall not
(except as otherwise expressly provided in this Agreement) of itself adversely affect the right of
Indemnitee to indemnification or create a presumption that Indemnitee did not act in good faith and
in a manner which he reasonably believed to be in or not opposed to the best interests of the
Company or, with respect to any criminal Proceeding, that Indemnitee had reasonable cause to
believe that his conduct was unlawful.

          8. Remedies of Indemnitee.

               (a) In the event that (i) a determination is made pursuant to Section 7 of this
Agreement that Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement
of Expenses is not timely made pursuant to Section 6 of this Agreement, (iii) no
determination of entitlement to indemnification is made pursuant to Section 7(b) of this
Agreement within 90 days after receipt by the Company of the request for indemnification, (iv)
payment of indemnification is not made pursuant to this Agreement within ten (10) days after
receipt by the Company of a written request therefor or (v) payment of indemnification is not made
within ten (10) days after a determination has been made that Indemnitee is entitled to
indemnification or such determination is deemed to have been made pursuant to Section 7 of
this Agreement, Indemnitee shall be entitled to an adjudication in an appropriate court of the
State of

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Delaware, or in any other court of competent jurisdiction, of Indemnitee’s entitlement to such
indemnification. Indemnitee shall commence such proceeding seeking an adjudication within 180 days
following the date on which Indemnitee first has the right to commence such proceeding pursuant to
this Section 8(a). The Company shall not oppose Indemnitee’s right to seek any such
adjudication.

               (b) In the event that a determination shall have been made pursuant to Section 7(b) of
this Agreement that Indemnitee is not entitled to indemnification, any judicial proceeding
commenced pursuant to this Section 8 shall be conducted in all respects as a de novo trial
on the merits, and Indemnitee shall not be prejudiced by reason of the adverse determination under
Section 7(b).

               (c) If a determination shall have been made pursuant to Section 7(b) of this Agreement
that Indemnitee is entitled to indemnification, the Company shall be bound by such determination in
any judicial proceeding commenced pursuant to this Section 8, absent (i) a misstatement by
Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s
misstatement not materially misleading in connection with the application for indemnification, or
(ii) a prohibition of such indemnification under applicable law.

               (d) In the event that Indemnitee, pursuant to this Section 8, seeks a judicial
adjudication of his rights under, or to recover damages for breach of, this Agreement, or to
recover under any directors’ and officers’ liability insurance policies maintained by the Company,
the Company shall pay on his behalf, in advance, any and all expenses (of the types described in
the definition of Expenses in Section 1 of this Agreement) actually and reasonably incurred
by him in such judicial adjudication, regardless of whether Indemnitee ultimately is determined to
be entitled to such indemnification, advancement of expenses or insurance recovery.

               (e) The Company shall be precluded from asserting in any judicial proceeding commenced
pursuant to this Section 8 that the procedures and presumptions of this Agreement are not
valid, binding and enforceable and shall stipulate in any such court that the Company is bound by
all the provisions of this Agreement. The Company shall indemnify Indemnitee against any and all
Expenses and, if requested by Indemnitee, shall (within ten (10) days after receipt by the Company
of a written request therefore) advance, to the extent not prohibited by law, such expenses to
Indemnitee, which are incurred by Indemnitee in connection with any action brought by Indemnitee
for indemnification or advance of Expenses from the Company under this Agreement or under any
directors’ and officers’ liability insurance policies maintained by the Company, regardless of
whether Indemnitee ultimately is determined to be entitled to such indemnification, advancement of
Expenses or insurance recovery, as the case may be.

               (f) Notwithstanding anything in this Agreement to the contrary, no determination as to
entitlement to indemnification under this Agreement shall be required to be made prior to the final
disposition of the Proceeding.

          9. Non-Exclusivity; Survival of Rights; Insurance; Subrogation.

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               (a) The rights of indemnification as provided by this Agreement shall not be deemed exclusive
of any other rights to which Indemnitee may at any time be entitled under applicable law, the
certificate of incorporation of the Company, the Bylaws, any agreement, a vote of stockholders, a
resolution of directors or otherwise. No amendment, alteration or repeal of this Agreement or of
any provision hereof shall limit or restrict any right of Indemnitee under this Agreement in
respect of any action taken or omitted by such Indemnitee in his Corporate Status prior to such
amendment, alteration or repeal. To the extent that a change in the DGCL, whether by statute or
judicial decision, permits greater indemnification than would be afforded currently under the
Bylaws and this Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by
this Agreement the greater benefits so afforded by such change. No right or remedy herein
conferred is intended to be exclusive of any other right or remedy, and every other right and
remedy shall be cumulative and in addition to every other right and remedy given hereunder or now
or hereafter existing at law or in equity or otherwise. The assertion or employment of any right
or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any
other right or remedy.

               (b) To the extent that the Company maintains an insurance policy or policies providing
liability insurance for directors, officers, employees, or agents or fiduciaries of the Company or
of any other corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise that such person serves at the request of the Company, Indemnitee shall be covered by
such policy or policies in accordance with its or their terms to the maximum extent of the coverage
available for any director, officer, employee, agent or fiduciary under such policy or policies.
If, at the time of the receipt of a notice of a claim pursuant to the terms hereof, the Company has
director and officer liability insurance in effect, the Company shall give prompt notice of the
commencement of such proceeding to the insurers in accordance with the procedures set forth in the
respective policies. The Company shall thereafter take all necessary or desirable action to cause
such insurers to pay, on behalf of the Indemnitee, all amounts payable as a result of such
proceeding in accordance with the terms of such policies.

               (c) In the event of any payment under this Agreement, the Company shall be subrogated to the
extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all papers
required and take all action necessary to secure such rights, including execution of such documents
as are necessary to enable the Company to bring suit to enforce such rights.

               (d) The Company shall not be liable under this Agreement to make any payment of amounts
otherwise indemnifiable hereunder if and to the extent that Indemnitee has otherwise actually
received such payment under any insurance policy, contract, agreement or otherwise.

               (e) The Company’s obligation to indemnify or advance Expenses hereunder to Indemnitee who is
or was serving at the request of the Company as a director, officer, employee or agent of any other
corporation, partnership, joint venture, trust, employee benefit plan or other enterprise shall be
reduced by any amount Indemnitee has actually received as indemnification or advancement of
expenses from such other corporation, partnership, joint venture, trust, employee benefit plan or
other enterprise.

10

 

          10. Exception to Right of Indemnification. Notwithstanding any provision in this
Agreement, the Company shall not be obligated under this Agreement to make any indemnity in
connection with any claim made against Indemnitee:

               (a) for which payment has actually been made to or on behalf of Indemnitee under any insurance
policy or other indemnity provision, except with respect to any excess beyond the amount paid under
any insurance policy or other indemnity provision; or

               (b) for an accounting of profits made from the purchase and sale (or sale and purchase) by
Indemnitee of securities of the Company within the meaning of Section 16(b) of the Securities
Exchange Act of 1934, as amended, or similar provisions of state statutory law or common law; or

               (c) in connection with any Proceeding (or any part of any Proceeding) initiated by Indemnitee,
including any Proceeding (or any part of any Proceeding) initiated by Indemnitee against the
Company or its directors, officers, employees or other indemnitees, unless (i) the Board authorized
the Proceeding (or any part of any Proceeding) prior to its initiation or (ii) the Company provides
the indemnification, in its sole discretion, pursuant to the powers vested in the Company under
applicable law.

          11. Duration of Agreement. All agreements and obligations of the Company contained
herein shall continue during the period Indemnitee is an officer or director of the Company (or is
or was serving at the request of the Company as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust or other enterprise) and shall continue thereafter
so long as Indemnitee shall be subject to any Proceeding (or any proceeding commenced under
Section 8 hereof) by reason of his Corporate Status, whether or not he is acting or serving
in any such capacity at the time any liability or expense is incurred for which indemnification can
be provided under this Agreement. This Agreement shall be binding upon and inure to the benefit of
and be enforceable by the parties hereto and their respective successors (including any direct or
indirect successor by purchase, merger, consolidation or otherwise to all or substantially all of
the business or assets of the Company), assigns, spouses, heirs, executors and personal and legal
representatives.

          12. Security. To the extent requested by Indemnitee and approved by the Board, the
Company may at any time and from time to time provide security to Indemnitee for the Company’s
obligations hereunder through an irrevocable bank line of credit, funded trust or other collateral.
Any such security, once provided to Indemnitee, may not be revoked or released without the prior
written consent of the Indemnitee.

11

 

          13. Enforcement.

               (a) The Company expressly confirms and agrees that it has entered into this Agreement and
assumes the obligations imposed on it hereby in order to induce Indemnitee to serve as an officer
or director of the Company, and the Company acknowledges that Indemnitee is relying upon this
Agreement in serving as an officer or director of the Company.

               (b) This Agreement constitutes the entire agreement between the parties hereto with respect to
the subject matter hereof and supersedes all prior agreements and understandings, oral, written and
implied, between the parties hereto with respect to the subject matter hereof.

          14. Severability. The invalidity of unenforceability of any provision hereof shall in
no way affect the validity or enforceability of any other provision. Without limiting the
generality of the foregoing, this Agreement is intended to confer upon Indemnitee indemnification
rights to the fullest extent permitted by applicable laws. In the event any provision hereof
conflicts with any applicable law, such provision shall be deemed modified, consistent with the
aforementioned intent, to the extent necessary to resolve such conflict.

          15. Modification and Waiver. No supplement, modification, termination or amendment of
this Agreement shall be binding unless executed in writing by both of the parties hereto. No
waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of
any other provisions hereof (whether or not similar) nor shall such waiver constitute a continuing
waiver.

          16. Notice By Indemnitee. Indemnitee agrees promptly to notify the Company in writing
upon being served with or otherwise receiving any summons, citation, subpoena, complaint,
indictment, information or other document relating to any Proceeding or matter which may be subject
to indemnification covered hereunder. The failure to so notify the Company shall not relieve the
Company of any obligation which it may have to Indemnitee under this Agreement or otherwise unless
and only to the extent that such failure or delay materially prejudices the Company.

          17. Notices. All notices and other communications given or made pursuant to this
Agreement shall be in writing and shall be deemed effectively given: (a) upon personal delivery to
the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during
normal business hours of the recipient, and if not so confirmed, then on the next business day, (c)
five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier,
specifying next day delivery, with written verification of receipt. All communications shall be
sent:

               (a) To Indemnitee at the address set forth below Indemnitee signature hereto.

12

 

               (b) To the Company at:

SUA Insurance Company

222 South Riverside Plaza

Suite 1600

Chicago, IL 60606

Attention: Scott Goodreau

or to such other address as may have been furnished to Indemnitee by the Company or to the Company
by Indemnitee, as the case may be.

          18. Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same
Agreement. This Agreement may also be executed and delivered by facsimile signature and in two or
more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

          19. Headings. The headings of the paragraphs of this Agreement are inserted for
convenience only and shall not be deemed to constitute part of this Agreement or to affect the
construction thereof.

          20. Governing Law and Consent to Jurisdiction. This Agreement and the legal relations
among the parties shall be governed by, and construed and enforced in accordance with, the laws of
the State of Delaware, without regard to its conflict of laws rules. The Company and Indemnitee
hereby irrevocably and unconditionally (i) agree that any action or proceeding arising out of or in
connection with this Agreement shall be brought only in the Delaware Court, and not in any other
state or federal court in the United States of America or any court in any other country, (ii)
consent to submit to the exclusive jurisdiction of the Delaware Court for purposes of any action or
proceeding arising out of or in connection with this Agreement, (iii) appoint, to the extent such
party is not otherwise subject to service of process in the State of Delaware, irrevocably The
Corporation Trust Company, Corporation Trust Center, 1209 Orange Street, Wilmington, DE 19801, as
its agent in the State of Delaware as such party’s agent for acceptance of legal process in
connection with any such action or proceeding against such party with the same legal force and
validity as if served upon such party personally within the State of Delaware, (iv) waive any
objection to the laying of venue of any such action or proceeding in the Delaware Court, and (v)
waive, and agree not to plead or to make, any claim that any such action or proceeding brought in
the Delaware Court has been brought in an improper or inconvenient forum.

SIGNATURE PAGE TO FOLLOW

13

 

          IN WITNESS WHEREOF, the parties hereto have executed this Agreement on and as of the day and
year first above written.

	 	 	 	 	 
	 	SPECIALTY UNDERWRITERS’ ALLIANCE, INC.

 	 
	 	By:  	
 	 
	 	Name:  	Scott Goodreau 	 
	 	Title:  	Senior Vice President, General Counsel 	 	 
	 
	 	INDEMNITEE

 	 
	 	
 	 
	 	Name:  	 	
 	 
	 	Address:EX-4.2

Exhibit 4.2

Eli Lilly And Company

Officers’ Certificate Pursuant to

Section 3.01 of the Indenture

March 6, 2009

          The undersigned, Thomas W. Grein, Senior Vice President and Treasurer of Eli Lilly and
Company, an Indiana corporation (the “Company”), and Bronwen Mantlo, Associate General
Counsel and Assistant Secretary of the Company, pursuant to Section 3.01 of the Indenture dated as
of February 1, 1991 (the “Indenture”), between the Company and Deutsche Bank Trust Company
Americas (as successor to Citibank, N.A.), as Trustee (the “Trustee”), as authorized by
resolutions of the Board of Directors of the Company, dated February 19, 2007 and October 1, 2008
and resolutions of the Risk Management Committee of the Company, dated February 17, 2009, do hereby
certify as follows:

          (i) There are hereby established three (3) series of debt securities to be issued under the
Indenture. The title of such series of the debt securities shall be the “3.550% Notes due 2012”
(the “3.550% Notes”), the “4.200% Notes due 2014” (the “4.200% Notes”) and the
“5.950% Notes due 2037” (the “5.950% Notes” and, collectively with the 3.550% Notes and
4.200% Notes, the “Notes”), respectively.

          (ii) The three series of Notes shall be in the forms, and shall have the terms, set forth as
Annex A-1, Annex A-2 and Annex A-3, respectively, attached hereto. The
Notes shall be issued in the form of Registered Securities and shall not be issued in the form of
Bearer Securities.

          (iii) The limit upon the aggregate principal amount of the Notes which may be authenticated
and delivered under the Indenture (except for Notes authenticated and delivered upon registration
or transfer of, or in exchange for, or in lieu of, other Notes pursuant to Section 3.04, 3.05,
3.06, 4.03 or 10.04 of the Indenture) is one billion Dollars ($1,000,000,000) with respect to the
3.550% Notes, one billion Dollars ($1,000,000,000) with respect to the 4.200% Notes and four
hundred million Dollars ($400,000,000) with respect to the 5.950% Notes; provided, however, that,
without the consent of the Holders of any Securities, the Company may issue additional Securities
having the same terms as the Notes of a particular series other than the date of original issuance
and the first Interest Payment Date applicable thereto. Any such additional Securities will
constitute a single series of Securities with such Notes under the Indenture.

          (iv) The principal amount of each Note shall be payable on March 6, 2012 with respect to the
3.550% Notes, March 6, 2014 with respect to the 4.200% Notes and November 15, 2037 with respect to
the 5.950% Notes, unless redeemed prior to such time in accordance with clause (xi) below.

          (v) The 3.550% Notes will bear interest at the rate of 3.550% per annum from March 6, 2009.
The 4.200% Notes will bear interest at the rate of 4.200% per annum from March 6, 2009. The 5.950%
Notes will bear interest at the rate of 5.950% per annum from March 6, 2009. The Interest Payment
Dates for the 3.550% Notes shall be March 6 and

 

 

September 6 of each year, commencing on September 6, 2009. The Interest Payment Dates for the
4.200% Notes shall be March 6 and September 6 of each year, commencing on September 6, 2009. The
Interest Payment Dates for the 5.950% Notes shall be May 15 and November 15 of each year,
commencing on May 15, 2009.

          (vi) Interest will be payable to the person in whose name a Note (or any Predecessor Security)
is registered at the close of business on the Regular Record Date immediately preceding the
applicable Interest Payment Date (or, in the case of Defaulted Interest, in the manner provided in
Section 3.07 in the Indenture). “Regular Record Date” for the 3.550% Notes and the 4.200% Notes
shall be the 15th calendar day immediately preceding the applicable Interest Payment Date, as the
case may be (whether or not a business day). “Regular Record Date” for the 5.950% Notes shall be
May 1 and November 1 (whether or not a business day).

          (vii) The Company will at all times maintain a Place of Payment for the Notes in the Borough
of Manhattan, The City of New York. The Company initially appoints Deutsche Bank Trust Company
Americas, with a corporate trust office at 60 Wall Street, 27th Floor, New York, New York 10005,
for such purpose.

          (viii) The Trustee is hereby appointed as the initial Paying Agent and the initial Security
Registrar with respect to the Notes.

          (ix) The Notes shall be denominated, and amounts due thereon shall be payable, solely in
Dollars.

          (x) The Notes shall not be subject to any sinking fund or analogous provisions, and no Holder
of the Notes shall have any right to cause the Company to redeem any Notes at the option of the
Holder.

          (xi) The Notes will be redeemable, in whole or in part, at the option of the Company at any
time at the redemption prices determined in accordance with, and upon the terms and the conditions
set forth in, the Notes and the Indenture.

          (xii) The Notes will be issuable upon original issuance in the form of Global Securities
registered in the name of The Depository Trust Company, as Depositary, or its nominee. The Global
Securities representing the Notes may be exchanged for definitive Notes only in the circumstances
set forth in the seventh or eighth paragraph of Section 3.05 of the Indenture and in accordance
with Section 3.05 of the Indenture.

          (xiii) The Notes shall be issued in minimum denominations of two thousand Dollars ($2,000.00)
and any integral multiples of one thousand Dollars ($1,000.00) in excess thereof.

          (xiv) Section 12.02 of the Indenture shall be applicable to the Notes.

          (xv) The Notes shall rank equally and pari passu with all other unsecured and unsubordinated
indebtedness of the Company.

2

 

          (xvi) The Company shall not pay any additional amounts on any of the Notes to any Person,
including any Holder who is not a United States Person, in respect of any tax, assessment or
governmental charge withheld or deducted.

          (xvii) For purposes of the Notes, the following terms shall have the meanings set forth below:

          (1) “Discharged” means that the Company will be deemed to have paid and discharged the entire
indebtedness represented by, and obligations under, the Securities of the series as to which
Section 12.02 is specified as applicable and to have satisfied all the obligations under this
Indenture relating to the Securities of such series (and the Trustee, at the expense of the
Company, will execute proper instruments acknowledging the same), except (A) the rights of Holders
thereof to receive, from the trust fund described in Section 12.02(q)(1), payment of the principal
of and the interest, if any, on such Securities when such payments are due, (B) the Company’s
obligations with respect to such Securities under Sections 3.05 and 3.06 (insofar as applicable to
Securities of such series), 12.02 and 5.02 and the Company’s obligations to the Trustee under
Section 7.05, (C) the rights of Holders of Securities of any series with respect to the currency or
currency units in which they are to receive payments of principal, premium, if any, and, interest
and (D) the rights, powers’ trusts, duties and immunities of the Trustee hereunder, will survive
such discharge. The Company will reimburse the trust fund for any loss suffered by it as a result
of any tax, fee or other charge imposed on or assessed against deposited U.S. Government
Obligations or Foreign Government Securities, as the case may be, or any principal or interest paid
on such obligations, and, subject to the provisions of Section 7.05, will indemnify the Trustee
against any claims made against the Trustee in connection with any such loss.

          (2) “Interest Payment Date,” when used with respect to any Security, means the Stated Maturity
of an installment of interest on such Security.

          (3) “Special Record Date” for the payment of any Defaulted Interest on the Registered Security
of any series means a date fixed by the Trustee pursuant to Section 3.07.

          (4) “Valuation Date” has the meaning specified in Section 3.11(e).

          Capitalized terms used herein without definition shall have the respective meanings ascribed
to such terms in the Indenture.

[The Remainder of This Page Intentionally Left Blank; Signature Page Follows]

3

 

          In Witness Whereof, the undersigned have hereunto set their hands on the date first
set forth above.

	 	 	 	 	 
	 	Eli Lilly and Company

 	 
	 	By  	/s/ Thomas W. Grein
 	 
	 	 	Name:  	Thomas W. Grein 	 
	 	 	Title:  	Senior Vice President and Treasurer 	 

	 	 	 	 	 
	 	 	 
	 	                                 /s/ Bronwen Mantlo
 	 
	 	Name:  	Bronwen Mantlo 	 
	 	Title:  	Associate General Counsel and

Assistant Secretary 	 
	 

4

 

Annex
A-1

Eli Lilly and Company

3.550% Note due 2012

			
	 	 	 
	Certificate No. [          ]
	 	CUSIP No. [                    ]
	Registered Global Security
	 	ISIN No. [                    ]

UNLESS THIS GLOBAL NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO
THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO.
OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC AND ANY PAYMENT IS MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS
WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN
INTEREST HEREIN.

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN
DEFINITIVE REGISTERED FORM, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED
EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
TO DTC OR ANOTHER NOMINEE OF DTC, OR BY DTC OR ANY SUCH NOMINEE TO A
SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

     Eli Lilly and Company, an Indiana corporation (the “Company,” which term includes any
successor corporation under the Indenture referred to herein), for value received, hereby promises
to pay to Cede & Co., or its registered assigns, the principal amount of [                    ]
Dollars ($[                    ]) on [          ], 20[     ] (the “Stated Maturity Date”), unless redeemed
on any Redemption Date (as defined on the reverse hereof) (the Stated Maturity Date or any
Redemption Date is referred to herein as the “Maturity Date” with respect to the principal
repayable on such date), upon surrender of this Note at the office or agency of the Company for
such payment in The City of New York, in such coin or currency of the United States of America as
at the time of payment shall be legal tender for the payment of public and private debts, and to
pay interest on the outstanding principal amount until the Maturity Date at the rate of 3.550% per
annum, in like coin or currency, semi-annually on March 6 and September 6 of each year, commencing
on September 6, 2009, until the date on which payment of said principal amount has been made or
duly provided for; provided, however, that if this Note is in the form of a Global Security, then
payments of principal of or premium, if any, or interest on this Note may be made at the Company’s
option by wire transfer of immediately available funds to the account specified by the Depositary
for this Note; provided further, that if this Note is not in the form of a Global Security, then
payments of principal of and premium, if any, and interest on this Note

 

 

may be made at the Company’s option by check mailed to the address of the person entitled
thereto as such address shall appear in the records of the Security Registrar. Interest on this
Note shall accrue on the outstanding principal amount thereof from, and including, the most recent
Interest Payment Date to which interest has been paid or provided for or, if no interest has been
paid or duly provided for, from, and including, March 6, 2009, in each case to, but excluding, the
applicable Interest Payment Date or the Maturity Date, as the case may be. Interest will be
computed on the basis of a 360-day year of twelve 30-day months. The interest payable on any
Interest Payment Date shall be payable to the person in whose name this Note is registered at the
close of business on the 15th calendar day (whether or not a Business Day) immediately preceding
such Interest Payment Date, except as otherwise provided in the Indenture.

     If the Maturity Date or any Interest Payment Date falls on a day which is not a Business Day,
principal, premium, if any, and interest, if any, payable with respect to the Maturity Date or such
Interest Payment Date, as the case may be, will be paid on the next succeeding Business Day with
the same force and effect as if made on the Maturity Date or such Interest Payment Date, as the
case may be, and no additional interest shall accrue on the amount so payable for the period from
and after the Maturity Date or such Interest Payment Date, as the case may be, to the next
succeeding Business Day. As used herein, “Business Day” means any day, other than a Saturday or
Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or
required by law or regulation to close in The City of New York.

     This Note is issued pursuant to, and shall be governed by, that certain Indenture (the
“Indenture”), dated as of February 1, 1991, between the Company and Deutsche Bank Trust Company
Americas (as successor to Citibank, N.A.), as Trustee (the “Trustee”). Capitalized terms used in
this Note without definition shall have the respective meanings ascribed to them in the Indenture.

     The provisions of this Note are continued on the reverse hereof, and such continued provisions
shall for all purposes have the same effect as though fully set forth at this place.

     Unless the certificate of authentication hereon has been executed by the Trustee by the manual
signature of one of its authorized officers, this Note shall not be entitled to the benefit under
the Indenture or be valid or obligatory for any purpose.

[This Space Intentionally Left Blank]

 

 

     In Witness Whereof, Eli Lilly and Company has caused this instrument to be duly
signed.

Dated: March 6, 2009

	 	 	 	 	 
	 	Eli Lilly and Company

 	 
	 	By:  	
 	 
	 	 	Name:  	Thomas W. Grein 	 
	 	 	Title:  	Senior Vice President and Treasurer 	 
	 
	 	  	
 	 
	 	 	Name:  	Bronwen Mantlo 	 
	 	 	Title:  	Associate General Counsel and

Assistant Secretary 	 
	 

[SEAL]

 

 

     This is one of the Securities of the series designated therein issued under the
within-mentioned Indenture.

	 	 	 	 	 
	 	Deutsche Bank Trust Company Americas, as

Trustee

 	 
	 	By:  	
 	 
	 	 	Authorized Officer 	 
	 	 	 	 

 

 

	 	 	 	 	 

[REVERSE OF NOTE]

     This Note is one of a duly authorized issue of a series of debt securities (the “Securities”)
of the Company, designated as its 3.550% Notes due 2012 (the “Notes”). The Securities, including
the Notes, are all issued or to be issued under and pursuant to the Indenture, to which Indenture,
and all Board Resolutions and Officer’s Certificates as provided therein, reference is hereby made
for a description of the rights, limitation of rights, obligations, duties and immunities
thereunder of the Company, the Trustee and the Holders of the Notes, and the terms upon which the
Notes are, and are to be, authenticated and delivered. The Notes are initially limited to one
billion Dollars ($1,000,000,000) aggregate principal amount; provided, however, that the Company
may at any time issue additional Securities under the Indenture in unlimited amounts having the
same terms as the Notes other than the date of original issuance and the first Interest Payment
Date applicable thereto, and such Securities shall be treated as a single series with the Notes for
all purposes under the Indenture.

     This Note will constitute part of the Company’s unsecured and unsubordinated obligations and
will rank equally in right of payment with all of the Company’s other existing and future unsecured
and unsubordinated indebtedness. This Note will be issuable in fully registered form only, in
minimum denominations of two thousand Dollars ($2,000) and any integral multiples of one thousand
Dollars ($1,000) in excess of that amount.

     In case an Event of Default shall have occurred and be continuing with respect to this Note,
the principal hereof may be declared due and payable, and upon such declaration shall become due
and payable, in the manner, with the effect, and subject to the conditions provided in the
Indenture. The Indenture permits the Holders of at least a majority in aggregate principal amount
of the Notes at the time outstanding to, on behalf of the Holders of all of the Notes and in the
manner and subject to the provisions of the Indenture, waive certain past defaults and rescind and
annul such past declarations and their consequences under the Indenture.

     The Indenture contains provisions permitting the Company and the Trustee, with consent of the
Holders of not less than a majority of the aggregate principal amount of the Notes at the time
outstanding, evidenced as provided in the Indenture, to execute supplemental indentures for the
purpose of adding any provisions to or changing in any manner or eliminating any of the provisions
of the Indenture or of any supplemental indenture with respect to the Notes or of modifying in any
manner the rights of the Holders of the Notes; provided, however, that no such supplemental
indenture shall (i) extend the fixed maturity, or the earlier optional date of maturity, if any, of
any Note, or reduce the principal amount thereof or the premium thereon, if any, or reduce the rate
or extend the time of payment of interest, if any, thereon or make the principal thereof or
premium, if any, or interest, if any, thereon payable in any currency other than as provided
pursuant to the Indenture or this Note, without the consent of the Holders of each Note so
affected; or (ii) reduce the aforesaid percentage of the Notes, the Holders of which are required
to consent to any such supplemental indenture, without the consent of the Holder of all Notes then
outstanding.

     The Notes shall not be entitled to the benefit of any mandatory redemption or sinking fund
provisions.

 

 

     Upon such notice as specified below and in accordance with the Indenture, the Notes are
subject to redemption, in whole or in part, at the election of the Company at any time or from time
to time, on a dated fixed for redemption (a “Redemption Date”) and at a “redemption price” equal to
the greater of the following amounts:

	 	(i)	 	100% of the principal amount of the Notes being redeemed on
such Redemption Date; and
	 
	 	(ii)	 	the sum of the present values of the remaining scheduled
payments of principal of and interest on the Notes being redeemed on such
Redemption Date (not including the amount, if any, of unpaid interest accrued
to, but excluding, such Redemption Date) discounted to such Redemption Date on
a semi-annual basis (assuming a 360-day year consisting of twelve 30-day
months) at the Treasury Rate (as defined below), plus 0.35% (or 35 basis
points);

plus, in each case, unpaid interest accrued on such Notes to, but excluding, such Redemption Date.

     Notwithstanding the foregoing, installments of interest on the Notes that are due and payable
on each Interest Payment Date falling on or prior to a Redemption Date will be payable on such
Interest Payment Date to the Holder(s) as of the close of business on the Regular Record Date
immediately preceding such Interest Payment Date.

     The Company shall mail notice of each redemption at least thirty (30) days but not more than
sixty (60) days before the Redemption Date to each Holder of Notes to be redeemed. Once notice of
redemption is mailed, the Notes called for redemption will become due and payable on the applicable
Redemption Date at the applicable redemption price.

     “Treasury Rate” means, with respect to any Redemption Date for the Notes, the rate per annum
equal to the semi—annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a
price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal
to the Comparable Treasury Price for such Redemption Date.

     “Comparable Treasury Issue” means, for the Notes, the United States Treasury security selected
by the Reference Treasury Dealer as having a maturity comparable to the remaining term of such
Notes to be redeemed that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities of comparable
maturity to the remaining term of such Notes.

     “Comparable Treasury Price” means, with respect to any Redemption Date and the Notes to be
redeemed, (A) if the Trustee obtains five or more Reference Treasury Dealer Quotations for such
Redemption Date and Notes, the average of such Reference Treasury Dealer Quotations after excluding
the highest and lowest of such Reference Treasury Dealer Quotations, (B) if the Trustee obtains
fewer than five but more than one Reference Treasury Dealer Quotation(s), the average of such
Reference Treasury Dealer Quotations, or (C) if the Trustee obtains only one Reference Treasury
Dealer Quotation, such Reference Treasury Dealer Quotation.

2

 

     “Reference Treasury Dealer” means (A) Credit Suisse Securities (USA) LLC, Deutsche Bank
Securities Inc. and UBS Securities LLC (or their respective affiliates that are Primary Treasury
Dealers), and their respective successors; provided, however, that if any of the foregoing shall
cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury
Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any other
Primary Treasury Dealer(s) selected by the Company.

     “Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer
and any Redemption Date and the Notes to be redeemed, the average, as determined by the Trustee, of
the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case
as a percentage of its principal amount) quoted in writing to the Trustee by such Reference
Treasury Dealer at 5:00 p.m. (New York City time) on the third (3rd) Business Day preceding such
Redemption Date.

     On and after any Redemption Date, interest will cease to accrue on the Notes or any portion of
the Notes called for redemption (unless the Company defaults in the payment of the redemption price
therefor). On or before any Redemption Date, the Company will deposit with a paying agent (or the
Trustee) money sufficient to pay the redemption price of the Notes to be redeemed on such date. If
fewer than all of the Notes are to be redeemed, then the Notes to be redeemed shall be selected by
lot by the Depositary, in the case of Notes represented by a Global Security, or by the Trustee by
a method the Trustee deems to be fair and appropriate, in the case of Notes that are not
represented by a Global Security.

     The Notes are subject to the defeasance provisions set forth in Section 12.02 of the
Indenture.

     The Company shall not pay any additional amounts on any of the Notes to any person, including
any Holder who is not a United States Person in respect of any tax, assessment or governmental
charge withheld or deducted.

     No reference herein to the Indenture and no provision of this Note or of the Indenture or of
any Board Resolution shall alter or impair the obligation of the Company, which is absolute and
unconditional, to pay the principal of and premium, if any, and interest on this Note at the times
and places and at the rate and in the coin and currency herein prescribed.

     This Note is transferable by the Holder hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency to be maintained by the Company for
that purpose in The City of New York, but only in the manner, subject to the limitations and upon
payment of any tax or governmental charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and cancellation of this Note. Upon any registration
of transfer, a new registered Note or Notes, of authorized denomination or authorized denominations
and like tenor and terms, and in the same aggregate principal amount, will be issued to the
transferee in exchange therefor.

     The Company, the Trustee, any Paying Agent and any Security Registrar may deem and treat the
Holder hereof as the absolute owner of this Note (whether or not this Note shall be overdue and
notwithstanding any notations of ownership or other writing hereon made

3

 

by anyone other than the Security Registrar) for the purpose of receiving payment of or on
account of the principal hereof and premium, if any, and interest due hereon as herein provided and
for all other purposes, and none of the Company, the Trustee, any Paying Agent or any Security
Registrar shall be affected by any notice to the contrary.

     No recourse shall be had for the payment of the principal of or premium, if any, or interest
on this Note, or for any claim based hereon, or otherwise in respect hereof, or based on or in
respect of the Indenture or any indenture supplemental thereto or any Board Resolution, against any
Person other than the Company or against any incorporator, stockholder, officer or director, past,
present or future, as such, of the Company or any other Person, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance hereof and as part of the consideration for
the issuance of this Note, expressly waived and released.

     This Note shall be governed by and construed in accordance with the laws of the State of New
York.

4

 

Annex
A-2

Eli Lilly and Company

4.200% Note due 2014

			
	 	 	 
	Certificate No. [     ]
	 	CUSIP No. [                    ]
	Registered Global Security
	 	ISIN No. [                    ]

UNLESS THIS GLOBAL NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO
THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO.
OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC AND ANY PAYMENT IS MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS
WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN
INTEREST HEREIN.

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN
DEFINITIVE REGISTERED FORM, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED
EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
TO DTC OR ANOTHER NOMINEE OF DTC, OR BY DTC OR ANY SUCH NOMINEE TO A
SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

     Eli Lilly and Company, an Indiana corporation (the “Company,” which term includes any
successor corporation under the Indenture referred to herein), for value received, hereby promises
to pay to Cede & Co., or its registered assigns, the principal amount of [                    ]
Dollars ($[                    ]) on [     ], 20[  ] (the “Stated Maturity Date”), unless redeemed
on any Redemption Date (as defined on the reverse hereof) (the Stated Maturity Date or any
Redemption Date is referred to herein as the “Maturity Date” with respect to the principal
repayable on such date), upon surrender of this Note at the office or agency of the Company for
such payment in The City of New York, in such coin or currency of the United States of America as
at the time of payment shall be legal tender for the payment of public and private debts, and to
pay interest on the outstanding principal amount until the Maturity Date at the rate of 4.200% per
annum, in like coin or currency, semi-annually on March 6 and September 6 of each year, commencing
on September 6, 2009, until the date on which payment of said principal amount has been made or
duly provided for; provided, however, that if this Note is in the form of a Global Security, then
payments of principal of or premium, if any, or interest on this Note may be made at the Company’s
option by wire transfer of immediately available funds to the account specified by the Depositary
for this Note; provided further, that if this Note is not in the form of a Global Security, then
payments of principal of and premium, if any, and interest on this Note

 

 

may be made at the Company’s option by check mailed to the address of the person entitled
thereto as such address shall appear in the records of the Security Registrar. Interest on this
Note shall accrue on the outstanding principal amount thereof from, and including, the most recent
Interest Payment Date to which interest has been paid or provided for or, if no interest has been
paid or duly provided for, from, and including, March 6, 2009, in each case to, but excluding, the
applicable Interest Payment Date or the Maturity Date, as the case may be. Interest will be
computed on the basis of a 360-day year of twelve 30-day months. The interest payable on any
Interest Payment Date shall be payable to the person in whose name this Note is registered at the
close of business on the 15th calendar day (whether or not a Business Day) immediately preceding
such Interest Payment Date, except as otherwise provided in the Indenture.

     If the Maturity Date or any Interest Payment Date falls on a day which is not a Business Day,
principal, premium, if any, and interest, if any, payable with respect to the Maturity Date or such
Interest Payment Date, as the case may be, will be paid on the next succeeding Business Day with
the same force and effect as if made on the Maturity Date or such Interest Payment Date, as the
case may be, and no additional interest shall accrue on the amount so payable for the period from
and after the Maturity Date or such Interest Payment Date, as the case may be, to the next
succeeding Business Day. As used herein, “Business Day” means any day, other than a Saturday or
Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or
required by law or regulation to close in The City of New York.

     This Note is issued pursuant to, and shall be governed by, that certain Indenture (the
“Indenture”), dated as of February 1, 1991, between the Company and Deutsche Bank Trust Company
Americas (as successor to Citibank, N.A.), as Trustee (the “Trustee”). Capitalized terms used in
this Note without definition shall have the respective meanings ascribed to them in the Indenture.

     The provisions of this Note are continued on the reverse hereof, and such continued provisions
shall for all purposes have the same effect as though fully set forth at this place.

     Unless the certificate of authentication hereon has been executed by the Trustee by the manual
signature of one of its authorized officers, this Note shall not be entitled to the benefit under
the Indenture or be valid or obligatory for any purpose.

[This Space Intentionally Left Blank]

 

 

     In Witness Whereof, Eli Lilly and Company has caused this instrument to be duly
signed.

Dated: March 6, 2009

	 	 	 	 	 
	 	Eli Lilly and Company

 	 
	 	By:  	 	 
	 	 	Name:  	Thomas W. Grein 	 
	 	 	Title:  	Senior Vice President and Treasurer 	 
	 
	 	 	 
	 	  	 	 
	 	 	Name:  	Bronwen Mantlo 	 
	 	 	Title:  	Associate General Counsel and

Assistant Secretary 	 
	 

[SEAL]

 

 

     This is one of the Securities of the series designated therein issued under the
within-mentioned Indenture.

	 	 	 	 	 
	 	Deutsche Bank Trust Company Americas, 
as
Trustee

 	 
	 	By:  	 	 
	 	 	Authorized Officer 	 
	 	 	 	 
	 

 

 

[REVERSE OF NOTE]

     This Note is one of a duly authorized issue of a series of debt securities (the “Securities”)
of the Company, designated as its 4.200% Notes due 2014 (the “Notes”). The Securities, including
the Notes, are all issued or to be issued under and pursuant to the Indenture, to which Indenture,
and all Board Resolutions and Officer’s Certificates as provided therein, reference is hereby made
for a description of the rights, limitation of rights, obligations, duties and immunities
thereunder of the Company, the Trustee and the Holders of the Notes, and the terms upon which the
Notes are, and are to be, authenticated and delivered. The Notes are initially limited to one
billion Dollars ($1,000,000,000) aggregate principal amount; provided, however, that the Company
may at any time issue additional Securities under the Indenture in unlimited amounts having the
same terms as the Notes other than the date of original issuance and the first Interest Payment
Date applicable thereto, and such Securities shall be treated as a single series with the Notes for
all purposes under the Indenture.

     This Note will constitute part of the Company’s unsecured and unsubordinated obligations and
will rank equally in right of payment with all of the Company’s other existing and future unsecured
and unsubordinated indebtedness. This Note will be issuable in fully registered form only, in
minimum denominations of two thousand Dollars ($2,000) and any integral multiples of one thousand
Dollars ($1,000) in excess of that amount.

     In case an Event of Default shall have occurred and be continuing with respect to this Note,
the principal hereof may be declared due and payable, and upon such declaration shall become due
and payable, in the manner, with the effect, and subject to the conditions provided in the
Indenture. The Indenture permits the Holders of at least a majority in aggregate principal amount
of the Notes at the time outstanding to, on behalf of the Holders of all of the Notes and in the
manner and subject to the provisions of the Indenture, waive certain past defaults and rescind and
annul such past declarations and their consequences under the Indenture.

     The Indenture contains provisions permitting the Company and the Trustee, with consent of the
Holders of not less than a majority of the aggregate principal amount of the Notes at the time
outstanding, evidenced as provided in the Indenture, to execute supplemental indentures for the
purpose of adding any provisions to or changing in any manner or eliminating any of the provisions
of the Indenture or of any supplemental indenture with respect to the Notes or of modifying in any
manner the rights of the Holders of the Notes; provided, however, that no such supplemental
indenture shall (i) extend the fixed maturity, or the earlier optional date of maturity, if any, of
any Note, or reduce the principal amount thereof or the premium thereon, if any, or reduce the rate
or extend the time of payment of interest, if any, thereon or make the principal thereof or
premium, if any, or interest, if any, thereon payable in any currency other than as provided
pursuant to the Indenture or this Note, without the consent of the Holders of each Note so
affected; or (ii) reduce the aforesaid percentage of the Notes, the Holders of which are required
to consent to any such supplemental indenture, without the consent of the Holder of all Notes then
outstanding.

     The Notes shall not be entitled to the benefit of any mandatory redemption or sinking fund
provisions.

 

 

     Upon such notice as specified below and in accordance with the Indenture, the Notes are
subject to redemption, in whole or in part, at the election of the Company at any time or from time
to time, on a dated fixed for redemption (a “Redemption Date”) and at a “redemption price” equal to
the greater of the following amounts:

	 	(i)	 	100% of the principal amount of the Notes being redeemed on
such Redemption Date; and
	 
	 	(ii)	 	the sum of the present values of the remaining scheduled
payments of principal of and interest on the Notes being redeemed on such
Redemption Date (not including the amount, if any, of unpaid interest accrued
to, but excluding, such Redemption Date) discounted to such Redemption Date on
a semi-annual basis (assuming a 360-day year consisting of twelve 30-day
months) at the Treasury Rate (as defined below), plus 0.35% (or 35 basis
points);

plus, in each case, unpaid interest accrued on such Notes to, but excluding, such Redemption Date.

     Notwithstanding the foregoing, installments of interest on the Notes that are due and payable
on each Interest Payment Date falling on or prior to a Redemption Date will be payable on such
Interest Payment Date to the Holder(s) as of the close of business on the Regular Record Date
immediately preceding such Interest Payment Date.

     The Company shall mail notice of each redemption at least thirty (30) days but not more than
sixty (60) days before the Redemption Date to each Holder of Notes to be redeemed. Once notice of
redemption is mailed, the Notes called for redemption will become due and payable on the applicable
Redemption Date at the applicable redemption price.

     “Treasury Rate” means, with respect to any Redemption Date for the Notes, the rate per annum
equal to the semi—annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a
price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal
to the Comparable Treasury Price for such Redemption Date.

     “Comparable Treasury Issue” means, for the Notes, the United States Treasury security selected
by the Reference Treasury Dealer as having a maturity comparable to the remaining term of such
Notes to be redeemed that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities of comparable
maturity to the remaining term of such Notes.

     “Comparable Treasury Price” means, with respect to any Redemption Date and the Notes to be
redeemed, (A) if the Trustee obtains five or more Reference Treasury Dealer Quotations for such
Redemption Date and Notes, the average of such Reference Treasury Dealer Quotations after excluding
the highest and lowest of such Reference Treasury Dealer Quotations, (B) if the Trustee obtains
fewer than five but more than one Reference Treasury Dealer Quotation(s), the average of such
Reference Treasury Dealer Quotations, or (C) if the Trustee obtains only one Reference Treasury
Dealer Quotation, such Reference Treasury Dealer Quotation.

2

 

     “Reference Treasury Dealer” means (A) Credit Suisse Securities (USA) LLC, Deutsche Bank
Securities Inc. and UBS Securities LLC (or their respective affiliates that are Primary Treasury
Dealers), and their respective successors; provided, however, that if any of the foregoing shall
cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury
Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any other
Primary Treasury Dealer(s) selected by the Company.

     “Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer
and any Redemption Date and the Notes to be redeemed, the average, as determined by the Trustee, of
the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case
as a percentage of its principal amount) quoted in writing to the Trustee by such Reference
Treasury Dealer at 5:00 p.m. (New York City time) on the third (3rd) Business Day preceding such
Redemption Date.

     On and after any Redemption Date, interest will cease to accrue on the Notes or any portion of
the Notes called for redemption (unless the Company defaults in the payment of the redemption price
therefor). On or before any Redemption Date, the Company will deposit with a paying agent (or the
Trustee) money sufficient to pay the redemption price of the Notes to be redeemed on such date. If
fewer than all of the Notes are to be redeemed, then the Notes to be redeemed shall be selected by
lot by the Depositary, in the case of Notes represented by a Global Security, or by the Trustee by
a method the Trustee deems to be fair and appropriate, in the case of Notes that are not
represented by a Global Security.

     The Notes are subject to the defeasance provisions set forth in Section 12.02 of the
Indenture.

     The Company shall not pay any additional amounts on any of the Notes to any person, including
any Holder who is not a United States Person in respect of any tax, assessment or governmental
charge withheld or deducted.

     No reference herein to the Indenture and no provision of this Note or of the Indenture or of
any Board Resolution shall alter or impair the obligation of the Company, which is absolute and
unconditional, to pay the principal of and premium, if any, and interest on this Note at the times
and places and at the rate and in the coin and currency herein prescribed.

     This Note is transferable by the Holder hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency to be maintained by the Company for
that purpose in The City of New York, but only in the manner, subject to the limitations and upon
payment of any tax or governmental charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and cancellation of this Note. Upon any registration
of transfer, a new registered Note or Notes, of authorized denomination or authorized denominations
and like tenor and terms, and in the same aggregate principal amount, will be issued to the
transferee in exchange therefor.

     The Company, the Trustee, any Paying Agent and any Security Registrar may deem and treat the
Holder hereof as the absolute owner of this Note (whether or not this Note shall be overdue and
notwithstanding any notations of ownership or other writing hereon made

3

 

by anyone other than the Security Registrar) for the purpose of receiving payment of or on
account of the principal hereof and premium, if any, and interest due hereon as herein provided and
for all other purposes, and none of the Company, the Trustee, any Paying Agent or any Security
Registrar shall be affected by any notice to the contrary.

     No recourse shall be had for the payment of the principal of or premium, if any, or interest
on this Note, or for any claim based hereon, or otherwise in respect hereof, or based on or in
respect of the Indenture or any indenture supplemental thereto or any Board Resolution, against any
Person other than the Company or against any incorporator, stockholder, officer or director, past,
present or future, as such, of the Company or any other Person, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance hereof and as part of the consideration for
the issuance of this Note, expressly waived and released.

     This Note shall be governed by and construed in accordance with the laws of the State of New
York.

4

 

Annex
A-3

Eli Lilly and Company

5.950% Note due 2037

	 	 	 
	Certificate No. [          ]

	 	CUSIP No. [                              ]
	Registered Global Security

	 	ISIN No. [                              ]

UNLESS THIS GLOBAL NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO
THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO.
OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC AND ANY PAYMENT IS MADE TO CEDE & CO., ANY TRANSFER, PLEDGE
OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS
WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN
INTEREST HEREIN.

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN
DEFINITIVE REGISTERED FORM, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED
EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC, OR BY A NOMINEE OF DTC
TO DTC OR ANOTHER NOMINEE OF DTC, OR BY DTC OR ANY SUCH NOMINEE TO A
SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

     Eli Lilly and Company, an Indiana corporation (the “Company,” which term includes any
successor corporation under the Indenture referred to herein), for value received, hereby promises
to pay to Cede & Co., or its registered assigns, the principal amount of [                    ]
Dollars ($[                    ]) on [          ], 20[     ] (the “Stated Maturity Date”), unless redeemed
on any Redemption Date (as defined on the reverse hereof) (the Stated Maturity Date or any
Redemption Date is referred to herein as the “Maturity Date” with respect to the principal
repayable on such date), upon surrender of this Note at the office or agency of the Company for
such payment in The City of New York, in such coin or currency of the United States of America as
at the time of payment shall be legal tender for the payment of public and private debts, and to
pay interest on the outstanding principal amount until the Maturity Date at the rate of 5.950% per
annum, in like coin or currency, semi-annually on May 15 and November 15 of each year, commencing
on May 15, 2009, until the date on which payment of said principal amount has been made or duly
provided for; provided, however, that if this Note is in the form of a Global Security, then
payments of principal of or premium, if any, or interest on this Note may be made at the Company’s
option by wire transfer of immediately available funds to the account specified by the Depositary
for this Note; provided further, that if this Note is not in the form of a Global Security, then
payments of principal of and premium, if any, and interest on this Note may be

 

 

made at the Company’s option by check mailed to the address of the person entitled thereto as
such address shall appear in the records of the Security Registrar. Interest on this Note shall
accrue on the outstanding principal amount thereof from, and including, the most recent Interest
Payment Date to which interest has been paid or provided for or, if no interest has been paid or
duly provided for, from, and including, March 6, 2009, in each case to, but excluding, the
applicable Interest Payment Date or the Maturity Date, as the case may be. Interest will be
computed on the basis of a 360-day year of twelve 30-day months. The interest payable on any
Interest Payment Date shall be payable to the person in whose name this Note is registered at the
close of business on May 1 or November 1 (whether or not a Business Day) immediately preceding such
Interest Payment Date, except as otherwise provided in the Indenture.

     If the Maturity Date or any Interest Payment Date falls on a day which is not a Business Day,
principal, premium, if any, and interest, if any, payable with respect to the Maturity Date or such
Interest Payment Date, as the case may be, will be paid on the next succeeding Business Day with
the same force and effect as if made on the Maturity Date or such Interest Payment Date, as the
case may be, and no additional interest shall accrue on the amount so payable for the period from
and after the Maturity Date or such Interest Payment Date, as the case may be, to the next
succeeding Business Day. As used herein, “Business Day” means any day, other than a Saturday or
Sunday, that is neither a legal holiday nor a day on which banking institutions are authorized or
required by law or regulation to close in The City of New York.

     
This Note is issued pursuant to, and shall be governed by, that certain Indenture (the
“Indenture”), dated as of February 1, 1991, between the Company and Deutsche Bank Trust Company
Americas (as successor to Citibank, N.A.), as Trustee (the “Trustee”). Capitalized terms used in
this Note without definition shall have the respective meanings ascribed to them in the Indenture.

     The provisions of this Note are continued on the reverse hereof, and such continued provisions
shall for all purposes have the same effect as though fully set forth at this place.

     Unless the certificate of authentication hereon has been executed by the Trustee by the manual
signature of one of its authorized officers, this Note shall not be entitled to the benefit under
the Indenture or be valid or obligatory for any purpose.

[This Space Intentionally Left Blank]

 

 

     In Witness Whereof, Eli Lilly and Company has caused this instrument to be duly
signed.

Dated: March 6, 2009

	 	 	 	 	 
	 	Eli Lilly and Company

 	 
	 	By:  	 	 
	 	 	Name:  	Thomas W. Grein 	 
	 	 	Title:  	Senior Vice President and Treasurer 	 
	 
	 	 	 
	 	  	
 	 
	 	 	Name:  	Bronwen Mantlo 	 
	 	 	Title:  	Associate General Counsel and

Assistant Secretary 	 
	 

[SEAL]

 

 

     This is one of the Securities of the series designated therein issued under the
within-mentioned Indenture.

	 	 	 	 	 
	 	Deutsche Bank Trust Company Americas, as

Trustee

 	 
	 	By:  	 	 
	 	 	Authorized Officer 	 
	 	 	 	 

 

 

	 	 	 	 	 

[REVERSE OF NOTE]

     This Note is one of a duly authorized issue of a series of debt securities (the “Securities”)
of the Company, designated as its 5.950% Notes due 2037 (the “Notes”). The Securities, including
the Notes, are all issued or to be issued under and pursuant to the Indenture, to which Indenture,
and all Board Resolutions and Officer’s Certificates as provided therein, reference is hereby made
for a description of the rights, limitation of rights, obligations, duties and immunities
thereunder of the Company, the Trustee and the Holders of the Notes, and the terms upon which the
Notes are, and are to be, authenticated and delivered. The Notes are initially limited to four
hundred million Dollars ($400,000,000) aggregate principal amount; provided, however, that the
Company may at any time issue additional Securities under the Indenture in unlimited amounts having
the same terms as the Notes other than the date of original issuance and the first Interest Payment
Date applicable thereto, and such Securities shall be treated as a single series with the Notes for
all purposes under the Indenture.

     This Note will constitute part of the Company’s unsecured and unsubordinated obligations and
will rank equally in right of payment with all of the Company’s other existing and future unsecured
and unsubordinated indebtedness. This Note will be issuable in fully registered form only, in
minimum denominations of two thousand Dollars ($2,000) and any integral multiples of one thousand
Dollars ($1,000) in excess of that amount.

     In case an Event of Default shall have occurred and be continuing with respect to this Note,
the principal hereof may be declared due and payable, and upon such declaration shall become due
and payable, in the manner, with the effect, and subject to the conditions provided in the
Indenture. The Indenture permits the Holders of at least a majority in aggregate principal amount
of the Notes at the time outstanding to, on behalf of the Holders of all of the Notes and in the
manner and subject to the provisions of the Indenture, waive certain past defaults and rescind and
annul such past declarations and their consequences under the Indenture.

     The Indenture contains provisions permitting the Company and the Trustee, with consent of the
Holders of not less than a majority of the aggregate principal amount of the Notes at the time
outstanding, evidenced as provided in the Indenture, to execute supplemental indentures for the
purpose of adding any provisions to or changing in any manner or eliminating any of the provisions
of the Indenture or of any supplemental indenture with respect to the Notes or of modifying in any
manner the rights of the Holders of the Notes; provided, however, that no such supplemental
indenture shall (i) extend the fixed maturity, or the earlier optional date of maturity, if any, of
any Note, or reduce the principal amount thereof or the premium thereon, if any, or reduce the rate
or extend the time of payment of interest, if any, thereon or make the principal thereof or
premium, if any, or interest, if any, thereon payable in any currency other than as provided
pursuant to the Indenture or this Note, without the consent of the Holders of each Note so
affected; or (ii) reduce the aforesaid percentage of the Notes, the Holders of which are required
to consent to any such supplemental indenture, without the consent of the Holder of all Notes then
outstanding.

     The Notes shall not be entitled to the benefit of any mandatory redemption or sinking fund
provisions.

 

 

     Upon such notice as specified below and in accordance with the Indenture, the Notes are
subject to redemption, in whole or in part, at the election of the Company at any time or from time
to time, on a dated fixed for redemption (a “Redemption Date”) and at a “redemption price” equal to
the greater of the following amounts:

	 	(i)	 	100% of the principal amount of the Notes being redeemed on
such Redemption Date; and
	 
	 	(ii)	 	the sum of the present values of the remaining scheduled
payments of principal of and interest on the Notes being redeemed on such
Redemption Date (not including the amount, if any, of unpaid interest accrued
to, but excluding, such Redemption Date) discounted to such Redemption Date on
a semi-annual basis (assuming a 360-day year consisting of twelve 30-day
months) at the Treasury Rate (as defined below), plus 0.35% (or 35 basis
points);

plus, in each case, unpaid interest accrued on such Notes to, but excluding, such Redemption Date.

     Notwithstanding the foregoing, installments of interest on the Notes that are due and payable
on each Interest Payment Date falling on or prior to a Redemption Date will be payable on such
Interest Payment Date to the Holder(s) as of the close of business on the Regular Record Date
immediately preceding such Interest Payment Date.

     The Company shall mail notice of each redemption at least thirty (30) days but not more than
sixty (60) days before the Redemption Date to each Holder of Notes to be redeemed. Once notice of
redemption is mailed, the Notes called for redemption will become due and payable on the applicable
Redemption Date at the applicable redemption price.

     “Treasury Rate” means, with respect to any Redemption Date for the Notes, the rate per annum
equal to the semi—annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a
price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal
to the Comparable Treasury Price for such Redemption Date.

     “Comparable Treasury Issue” means, for the Notes, the United States Treasury security selected
by the Reference Treasury Dealer as having a maturity comparable to the remaining term of such
Notes to be redeemed that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities of comparable
maturity to the remaining term of such Notes.

     “Comparable Treasury Price” means, with respect to any Redemption Date and the Notes to be
redeemed, (A) if the Trustee obtains five or more Reference Treasury Dealer Quotations for such
Redemption Date and Notes, the average of such Reference Treasury Dealer Quotations after excluding
the highest and lowest of such Reference Treasury Dealer Quotations, (B) if the Trustee obtains
fewer than five but more than one Reference Treasury Dealer Quotation(s), the average of such
Reference Treasury Dealer Quotations, or (C) if the Trustee obtains only one Reference Treasury
Dealer Quotation, such Reference Treasury Dealer Quotation.

2

 

     “Reference Treasury Dealer” means (A) Credit Suisse Securities (USA) LLC, Deutsche Bank
Securities Inc. and UBS Securities LLC (or their respective affiliates that are Primary Treasury
Dealers), and their respective successors; provided, however, that if any of the foregoing shall
cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury
Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any other
Primary Treasury Dealer(s) selected by the Company.

     “Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer
and any Redemption Date and the Notes to be redeemed, the average, as determined by the Trustee, of
the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case
as a percentage of its principal amount) quoted in writing to the Trustee by such Reference
Treasury Dealer at 5:00 p.m. (New York City time) on the third (3rd) Business Day preceding such
Redemption Date.

     On and after any Redemption Date, interest will cease to accrue on the Notes or any portion of
the Notes called for redemption (unless the Company defaults in the payment of the redemption price
therefor). On or before any Redemption Date, the Company will deposit with a paying agent (or the
Trustee) money sufficient to pay the redemption price of the Notes to be redeemed on such date. If
fewer than all of the Notes are to be redeemed, then the Notes to be redeemed shall be selected by
lot by the Depositary, in the case of Notes represented by a Global Security, or by the Trustee by
a method the Trustee deems to be fair and appropriate, in the case of Notes that are not
represented by a Global Security.

     The Notes are subject to the defeasance provisions set forth in Section 12.02 of the
Indenture.

     The Company shall not pay any additional amounts on any of the Notes to any person, including
any Holder who is not a United States Person in respect of any tax, assessment or governmental
charge withheld or deducted.

     No reference herein to the Indenture and no provision of this Note or of the Indenture or of
any Board Resolution shall alter or impair the obligation of the Company, which is absolute and
unconditional, to pay the principal of and premium, if any, and interest on this Note at the times
and places and at the rate and in the coin and currency herein prescribed.

     This Note is transferable by the Holder hereof in person or by his attorney duly authorized in
writing on the books of the Company at the office or agency to be maintained by the Company for
that purpose in The City of New York, but only in the manner, subject to the limitations and upon
payment of any tax or governmental charge for which the Company may require reimbursement as
provided in the Indenture, and upon surrender and cancellation of this Note. Upon any registration
of transfer, a new registered Note or Notes, of authorized denomination or authorized denominations
and like tenor and terms, and in the same aggregate principal amount, will be issued to the
transferee in exchange therefor.

     The Company, the Trustee, any Paying Agent and any Security Registrar may deem and treat the
Holder hereof as the absolute owner of this Note (whether or not this Note shall be overdue and
notwithstanding any notations of ownership or other writing hereon made

3

 

by anyone other than the Security Registrar) for the purpose of receiving payment of or on
account of the principal hereof and premium, if any, and interest due hereon as herein provided and
for all other purposes, and none of the Company, the Trustee, any Paying Agent or any Security
Registrar shall be affected by any notice to the contrary.

     No recourse shall be had for the payment of the principal of or premium, if any, or interest
on this Note, or for any claim based hereon, or otherwise in respect hereof, or based on or in
respect of the Indenture or any indenture supplemental thereto or any Board Resolution, against any
Person other than the Company or against any incorporator, stockholder, officer or director, past,
present or future, as such, of the Company or any other Person, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or
otherwise, all such liability being, by the acceptance hereof and as part of the consideration for
the issuance of this Note, expressly waived and released.

     This Note shall be governed by and construed in accordance with the laws of the State of New
York.

4

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