Document:

Exhibit 10.18

    
      
        

      

    

     

    
      AUDUBON
        BIOMEDICAL SCIENCE AND TECHNOLOGY PARK

      Columbia
        University Health Sciences Division 

      

      LICENSE
        AGREEMENT

      

      AGREEMENT
        made as of; August 1, 2004 between THE TRUSTEES OF COLUMBIA UNIVERSITY IN
        THE
        CITY OF NEW YORK ("Licensor"),
        having an office c/o Executive Director, Audubon Research Park, 3960 Broadway,
        New York, New York 10032 and Neurologix,
        Inc.
        ("Licensee"),
        having an office at One
        Bridge Plaza, Fort Lee, NJ 07024.

      

      W
        I T
        N E S S E T H

      

      WHEREAS,
        Licensee desires to acquire a license to use space at the Audubon Business
        and
        Technology Center in the Mary Woodard Lasker Building (the "Building"),
        located at 3960 Broadway in the City, County and State of New York;
        and

      

      WHEREAS,
        Licensor is agreeable to granting to Licensee a license to use space in the
        Building on the terms and conditions hereinafter set forth.

      

      NOW,
        THEREFORE, the parties agree as follows:

      

      1.             
        LICENSE.
        Licensor does hereby grant to Licensee a nontransferable license to use certain
        space (the "Licensed
        Space")
        on the
        5th
        floor of
        the Building as more particularly shown on Exhibit "A" annexed hereto and
        made a
        part hereof.

      

      2.             
        TERM.
        The
        term of this Agreement (the "Term")
        shall
        commence on the date hereof (the "Commencement
        Date"),
        and
        shall, unless sooner terminated in accordance with the terms hereof or pursuant
        to law, continue until July 31, 2005 (the "Expiration
        Date").

      

      3.             
        CONDITION
        OF PREMISES.
        Licensee acknowledges that it has inspected the Licensed Space and agrees
        to
        take the Licensed Space "as is" without any work being done therein by Licensor,
        and without any obligation upon Licensor to make any contribution toward
        or to
        assume the performance of any work in order to prepare the Licensed Space
        for
        use by Licensee. Licensee acknowledges that all materials, fixtures and
        equipment, if any, which Licensor may elect to make available for Licensee's
        use
        are, and shall be and remain, the property of Licensor. Licensee acknowledges
        that Licensor has not made and does not make any representation or warranties
        to
        Licensee, whether directly or indirectly, with respect to the Licensed Space
        or
        the use or proposed use thereof by Licensee.

      

      4.              USE.
        Licensee shall use the Licensed Space solely as laboratory and office space.
        Prior to taking occupancy of the Licensed Space, Licensee shall submit to
        Licensor for approval, Licensee's Regulatory Compliance Plan (the "Plan")
        which
        Plan shall (a) identify these activities and materials to be used by Licensee
        which are or may be subject to Environmental Legal Requirements (as hereinafter
        defined) or other Legal Requirements (as hereinafter defined) and (b) detail
        Licensee's plans and procedures for compliance with Environmental Legal
        Requirements, Legal Requirements and Insurance Requirements (as hereinafter
        defined) as to each specific regulated material and activity. From time to
        time,
        at any time during the Term, Licensee shall revise the Plan to reflect any
        Changes in its activities, materials, Environmental Legal Requirements, Legal
        Requirements or Insurance Requirements. The Plan and all such revisions shall
        be
        subject to Licensor's prior review and approval.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      5.            
        FEE.
        (a)
        Licensee agrees to pay to Licensor as and for the use of the Licensed Space
        during the Term an annual amount (the "License
        Fee")
        as set
        forth on Exhibit
        "B"
        annexed
        hereto and made a part hereof. The License Fee shall be paid in monthly
        installments as set forth on Exhibit
        "B",
        in
        advance, on the first day of each and every month during the Term, without
        offset or deduction except that the first monthly installment shall be paid
        upon
        execution hereof. If the Commencement Date shall occur on a day other than
        the
        first day of a calendar month or if the Expiration Date shall occur on a
        day
        other than the last day of a calendar month, the License Fee for such calendar
        month shall be appropriately prorated.

      

      (b) All
        other
        sums of money shall become due and payable by Licensee to Licensor hereunder
        (collectively, "License Consideration") shall be paid to Licensor within
        ten
        (10) days after receipt by Licensee of bills or notice from Licensor to Licensee
        identifying the same. If Licensee shall fail to pay any License Consideration
        within such ten (10) day period, or shall fail to pay any installment of
        the
        License Fee within ten (10) days after it is due, such unpaid amounts shall
        bear
        interest at the rate per annum equal to the lesser of (i) two percent (2%)
        plus
        the base rate charged by Citibank, N.A. and in effect during the period such
        amounts are due and unpaid and (ii) the maximum rate permitted by law, from
        the
        due date of such payment to the date paid to Licensor.

      

      (c) If
        Licensee shall default in performing any term, covenant or condition of this
        Agreement which shall involve the expenditure of money by Licensee to third
        parties, and such default shall continue beyond applicable notice and grace
        period, Licensor may (but shall not be obligated to) make such payment or,
        on
        behalf of Licensee, expend such sum as may be necessary to perform or fulfill
        such term, covenant or condition. All sums so paid or expended by Licensor
        shall
        be deemed to be License Consideration and shall be payable by Licensee to
        Licensor in accordance with Paragraph 5(b) above. No such payment or expenditure
        by Licensor shall be construed as a waiver of Licensee's default or of
        Licensee's obligation to perform any term, covenant or condition of this
        License
        Agreement nor shall it affect any other right or remedy of Licensor under
        this
        License Agreement.

      

      6.            
        COVENANTS
        AND WARRANTS.
        Licensee covenants and warrants:

      

      (a) at
        Licensee's sole cost and expense, to keep and maintain the Licensed Space
        in
        good order and condition, to notify Licensor of any needed repairs, which
        repairs shall be performed by Licensor at Licensee's sole cost and expense,
        and
        to quit and surrender the Licensed Space to Licensor upon the expiration
        or
        earlier termination of this Agreement in as good and proper order and condition
        as at the Commencement date, reasonable wear and tear excepted.

      
        
          
          

        

        
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      (b) At
        Licensee's sole cost and expense, to comply promptly with (1) all presently
        existing or hereafter enacted laws, orders, ordinances, rules, regulations
        and
        requirements of, and to keep in full force and effect all permits and licenses
        required pursuant to all federal, state, municipal and local governments
        and
        their departments, agencies, commissions, boards and officers or any other
        body
        exercising similar jurisdiction and any other governmental agency having
        jurisdiction over the Licensed Space (collectively, "Legal
        Requirements");
        (2)
        all orders rules, regulations, requirements and recommendations of the New
        York
        Board of Fire Underwriters or the Insurance Service Office or any other body
        exercising the same or similar functions and having jurisdiction or cognizance
        of all or any part of the Licensed Space or the Building (collectively,
        "Insurance
        Requirements");
        (3)
        any and all policies and procedures of Licensor (including, without limitation,
        Licensor's Joint Radiation Safety Committee and Licensor's Office of
        Environmental Health and Safety) governing the use, handling or disposal
        of
        Hazardous Materials (as hereinafter defined) by its tenants, licensors,
        contractors, employees or researchers, now or hereafter in effect, and (4)
        any
        applicable federal, state or local statute, code, ordinance, rule or regulation,
        any judicial or administrative order or judgment applicable to Licensee or
        the
        Licensed Space and any provision or condition of any permit, license, franchise,
        concession, agreement or other authorization binding on Licensee relating
        to (i)
        the protection of the environment, the safety and health of persons (including
        employees) or the public welfare, (ii) the actual or potential release,
        discharge, disposal or emission (whether past or present) of any Hazardous
        Materials or (iii) the manufacture, processing, distribution, use, treatment,
        storage, disposal, transport generation or handling of any Hazardous Materials
        (collectively, "Environment
        Legal Requirements").
        The
        term "Hazardous
        Materials"
        shall
        mean any flammable, explosive, radioactive, chemical or infectious materials,
        hazardous (or biohazardous) materials or wastes, medical wastes, hazardous
        or
        toxic substances, pollutants, gas, vapor, radiation, chemical or related
        materials, asbestos or any material containing asbestos, or any other substance
        or materials as defined in or regulated by any local, state or federal law
        or
        ordinance or regulation promulgated pursuant thereto;

      

      (c) not
        to
        use, except to identify Licensee's address (i) as part of its mailing address
        on
        letterhead and other similar materials or (ii) for purposes of Licensee's
        publications, the name of Licensor or Columbia University or any of its
        officers, trustees, agents, employees, students or faculty members for any
        purpose whatsoever without receiving the prior written approval of Licensor.
        Without limiting the generality of the foregoing, Licensee shall not conduct
        its
        operations at the Licensed Space under any name which includes the word
        Columbia", or otherwise hold itself or its business out as having any
        affiliation with Licensor or Columbia University or Columbia-Presbyterian
        Medical Center:

      

      (d) to
        comply
        strictly with the Plan (as defined in Paragraph 4 hereof);

      
        
          
          

        

        
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      (e) not
        to
        use or permit the use of biohazardous agents requiring a degree of containment
        in excess of that described as National Institutes of Health Biosafety Level
        2
        as defined in the U.S. Department of Health and Human Services, Public Health
        Service, Centers for Disease Control and Prevention and National Institutes
        of
        Health, Biosafety
        in Microbiological and Biomedical Laboratories,
        dated
        May, 1993 and any updates or revisions thereto (the "DHH
        Specifications")

      

      (f) to
        conduct all scientific research and development activities in conformity
        with at
        least the minimum practices, equipment and facilities recommended for such
        activities in the DHH Specifications; and

      

      (g) not
        to
        use or permit the use of any human subjects or live and whole dead animals
        (including, without limitation, live and whole dead mice and rats) on or
        at the
        Licensed Space for any research purposes. In the event that Licensee at any
        time
        during the Term shall desire to (a) use or permit the use of human subjects
        or
        live or whole dead animals for research at the Building or (b) use or permit
        the
        use of any of the facilities of Licensor to house any live or whole dead
        animals, Licensee shall forward a request with appropriate back-up
        documentation, including, without limitation, a detailed description of
        Licensee's proposed research, to Licensor at the address set forth in Paragraph
        17 hereof. Upon receipt of such notice and back-up documentation, Licensor
        shall
        review such request, provided, however, that Licensor shall, in its sole
        and
        absolute discretion, have no obligation to consent to Licensee's
        request.

      

      7.            
        INSURANCE.
        Licensee shall, at Licensee's sale cost and expense, obtain and maintain
        the
        following types of insurance in not less than the indicated amounts with
        insurance carriers reasonably acceptable to Licensor and otherwise in compliance
        with Exhibit
        "C"
        annexed
        hereto and made a part hereof;

      

      (a) Workers'
        Compensation and Employer's Liability insurance with respect to all persons
        employed by Licensee at the Licensed Space with a limit of liability in
        accordance with applicable law in the case of Workers' Compensation and with
        a
        limit of liability of not less than the following in the case of Employer's
        Liability:

      

      Bodily
        Injury by Accident - $100,000 each accident;

      

      Bodily
        Injury by Disease - $500,000 policy limit; 

      

      Bodily
        Injury by Disease - $100,000 each employee; 

      

      (b) Comprehensive
        General Liability (bodily injury and property damage) with a combined single
        limit of liability for bodily injury and property damage of $2,000,000 per
        occurrence. Licensor shall be named as an additional insured under this
        policy;

      

      (c) "All
        Risk" property insurance ( including breakage of glass and water damage)
        to all
        property of Licensee, including all alterations, within the Licensed Space
        in an
        amount equal to the replacement cost of such property; and

      
        
          
          

        

        
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      (d) Such
        different or the same types of insurance set forth above in such amounts
        as may
        from time to time be reasonably required by Licensor against such other
        incurable hazards as at the time are commonly insured against in the case
        of
        premises similarly situated.

      

      8.            
        DAMAGE
        AND DESTRUCTION.
        (a)
        If the
        Licensed Space or any part thereof shall be damaged by fire or other casualty,
        Licensee shall give immediate notice thereof to Licensor and this Agreement
        shall continue in full force and effect, unless Licensor shall elect to
        terminate this Agreement as set forth below. In the event that this Agreement
        shall not be so terminated, Licensor shall restore the Licensed Space at
        Licensor's expense and the Licensee fee and License Consideration shall be
        proportionately abated during the period in which Licensor is restoring the
        Licensed Space if all or any portion of the Licensed Space is unusable by
        Licensee for the purposes set for the in Paragraph 4 above during such period.
        Licensee's liability for the full amount of the Licensee Fee and License
        Consideration shall resume five (5) days after written notice from Licensor
        that
        the Licensed Space is substantially ready for Licensee's occupancy.

      

      (b) In
        the
        event that the Licensed Space is rendered wholly or substantially unusable
        (whether or not the Licensed Space has been damaged in whole or in part)
        by fire
        or other casualty (of which fact Licensor shall be the sole judge), Licensor
        may
        elect to terminate this Agreement by written notice to Licensee given within
        sixty (60) days after such fire or casualty, specifying the date for the
        expiration of this Agreement, which shall be no more than thirty (30) days
        after
        the giving of such notice.

      

      (c) If
        Licensor shall fail within thirty (30) days after notice by Licensee to Licensor
        of such casualty to restore the damaged portion of the Licensed Space to
        substantially the condition existing prior to such casualty. Licensee may
        elect
        to terminate this Agreement by written notice to Licensor giving prior to
        completion of such restoration, specifying the date for the expiration of
        this
        Agreement, which shall be no more than thirty (30) days after the giving
        of such
        notice.

      

      (d) 
        Nothing
        contained herein shall relieve Licensee from liability that may exist as
        a
        result of damage from fire or other casualty. Notwithstanding the foregoing,
        each party shall look first to any insurance in its favor before making any
        claim against the other party for recovery for loss or damage resulting from
        fire or other casualty, and to the extent that such insurance is in force
        and
        collectible and to the extent permitted by law, Licensor and Licensee each
        hereby releases and waives all rights of recovery against the other or anyone
        claiming through or under the other, by way of subrogation or otherwise.
        The
        foregoing release and waiver shall be in force only if both parties' insurance
        policies contain a clause providing that such a release or waiver shall not
        invalidate the insurance and also provided that such clause can be obtained
        without additional premium; it being agreed, however, that the party whose
        insurance carrier requires such additional premium shall notify the other
        party
        thereof and such other party shall have the right to pay such additional
        premium.

      
        
          
          

        

        
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      (e) Licensee
        acknowledges that Licensor will not carry insurance on the improvements,
        furniture, furnishings, fixtures and equipment and other personal property
        required to be insured by Licensee pursuant to Paragraph 7(a) above and Licensor
        will not be obligated to repair any damage thereto or replace the
        same.

      

      (f) Licensee
        hereby waives the provisions of Section 227 of the Real Property Law and
        agrees
        that the provisions of this Paragraph 8 shall govern and control in lieu
        thereof. 

      

      9.             ALTERATIONS.
        Licensee shall not make any improvements, additions, alterations or other
        changes, except for cosmetic and decorative alterations, to the Licensed
        Space,
        without the prior written consent of Licensor in each instance.

      

      10.          
        UTILITIES
        AND SERVICES.
        (a)
        Licensee shall have 24-hour, 7-day-a-week access to the Building and passenger
        elevator service to the Licensed Space. Freight elevator service shall be
        available on business days from 8 a.m. to 4 p.m. If Licensee shall require
        freight elevator service during any other time, Licensor shall furnish same
        provided that Licensee gives Licensor advance notice and that Licensee pays,
        on
        demand, as License Consideration, Licensor's than established charges
        therefor.

      

      (b) Licensor
        shall provide electric energy to the Licensed Space. Licensee shall pay Licensor
        for electricity consumed by Licensee in the Licensed Space. Licensor will
        permit
        the electrical risers, feeders and wiring in the Building serving the Licensed
        Space to be used by Licensee for such purpose to the extent that they are
        available, suitable, safe and within the plan and design capacities of the
        Building. Licensee shall not be required to pay Licensor more than the amount
        calculated by applying to the measured demand and/or usage of electrical
        current
        in or furnished to the Building, the average rate per unit of measurement,
        inclusive of applicable taxes, surcharges, time of day and other charges,
        payable by Licensor for electrical current furnished to the License Space
        by the
        utility company serving the Building. Should any tax or charge in the nature
        of
        a tax be imposed upon Licensor's receipts from the sale or resale of electrical
        current to the Licensed Space, then the pro rata share thereof allocable
        to the
        electrical current furnished to the Licensed Space shall be passed on to
        and
        paid by the Licensor. Bills for Licensee's usage of electrical current shall
        be
        paid within ten (10) days by Licensee as License Consideration. If due to
        any
        change in Legal Requirements Licensor shall not be permitted to provide electric
        energy to the Licensed Space, then this Agreement shall not be affected and
        Licensee shall arrange to obtain electric energy directly from the public
        utility company furnishing electrical service to the Building. In such event
        Licensee shall no longer pay Licensor for electricity consumed.

      
        
          
          

        

        
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      (c) Licensee's
        use of electrical energy shall never exceed the capacity of the then existing
        risers or wiring installation, in each case. In order to insure that such
        electrical capacity is not exceeded and to avert possible adverse effect
        upon
        the Building's electrical system, Licensee shall not, without the prior written
        consent of Licensor, make or perform or permit any alteration to wiring
        installations or other electrical facilities in or serving the Licensed Space
        or
        any additions to the electrical fixtures, machines or equipment or appliances
        in
        the Licensed Space. Licensor shall not be obligated to consent to any such
        alteration or installation if, in Licensor's judgment, the same are unnecessary
        or will cause permanent damage or injury to the Building, the Building equipment
        or the License Space or will cause or create a hazardous condition or entail
        excessive or unreasonable alterations, repairs or expense or interfere with
        or
        disturb other tenants or occupants. Only rigid conduit or such other wiring
        or
        conduit as shall not violate Legal Requirements will be allowed.

      

      (d) Licensor
        shall have no liability to License for any loss, damage or expense which
        Licensee may sustain or incur by reason of any change, failure, inadequacy
        or
        defect in the supply or character of the electrical energy or emergency
        generator back-up power furnished to the Licensed Space or if the quantity
        or
        character of the electrical energy is no longer available or suitable for
        Licensee's requirements, except for any actual damage suffered by Licensee
        by
        reason of any such failure, inadequacy or defect caused by Licensor's gross
        negligence, and then only after actual notice thereof. 

      

      (e) Licensor
        shall make available from the public water supply to a point or points at
        or
        near the Licensed Space selected by Licensor such quantities of domestic
        cold
        and hot water as Licensor, in its sole and absolute judgment, deems adequate
        for
        normal laboratory and ordinary lavatory, cleaning and drinking purposes.
        In the
        event that the Licensee requires hot or cold water of any purposes other
        than
        those specified in the preceding sentence, including, but not limited to
        high
        volume laboratory usage, Licensee shall pay Licensor, as License Consideration,
        for water consumed, as shown on separate submeters for cold and hot water
        maintained by License, together with all sewer charges and any other rent,
        tax,
        levy or charge based thereon which now or hereafter is assessed, imposed
        or a
        lien upon the Licensed Space or the Building, as and when bills are rendered.
        Payment for cold water shall be at the rate charged by the City for cold
        water.
        Payment for hot water shall be at three (3) times such rate. Licensor shall
        have
        no liability to Licensee for any loss, damage or expense which Licensee may
        sustain or incur if the quantity or character of water service changes or
        is no
        longer available or suitable for Licensee's purposes.

      

      (f) Licensee
        shall notify Licensor, within then (10) days after the Commencement Date,
        of the
        water meter number of each water meter serving the Licensed Space and whether
        such meter is for hot water or cold water. If any such meter is installed
        subsequent to the taking of possession by Licensee, then Licensee shall notify
        Licensor of such information within ten (10) days after such
        installation.

      

      (g) Licensor
        shall make available to a point or points at or near the Licensed Space such
        piping, systems, equipment and facilities as Licensor, in its sole and absolute
        judgment, deems adequate to provide gas service for normal laboratory
        consumption. Licensee shall pay Licensor, as License Consideration, for any
        and
        all gas consumed. Meters may be installed and maintained by Licensor, at
        Licensee's sole cost and expense. The rates charged by Licensor to Licensee
        for
        gas consumption shall not exceed the rates charged by the utility company
        providing such service. Payment for gas consumed by Licensee in the Licensed
        Space shall be made by Licensee as License Consideration within ten (10)
        days of
        Licensor's bill therefor. Licensee shall make no alteration, addition or
        repair
        to the gas connection, installations, equipment and/or facilities without
        the
        prior written consent of Licensor in each instance. Licensor shall have no
        liability to Licensee for any loss, damage or expense which Licensee may
        sustain
        or incur if the quantity or character of the gas service is changed or is
        no
        longer available or suitable for Licensee's requirements.

      
        
          
          

        

        
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      (h) Licensor
        shall, without additional charge to Licensee, supply hot water for heat,
        and
        chilled water for air conditioning and ventilation to the License Space
        throughout existing Building risers, radiators and air handlers during
        appropriate seasons as may reasonably be required by Licensee for ambient
        heating and cooling seven days a week, 24 hours a day.

      

      (i) Licensor
        shall provide cleaning services in accordance with the specifications annexed
        hereto at Exhibit
        D
        and made
        a part hereof.

      

      (j) Licensor
        shall supply compressed air and vacuum air to a point or points near the
        Licensed Space in quantities which Licensor deems adequate for normal laboratory
        purposes. If Licensee shall require additional compressed air and vacuum
        air in
        excess of that which Licensor deems adequate for the purposes set forth herein,
        Licensor shall furnish same at Licensor's then established rates and same
        shall
        be payable by Licensee as License Consideration within ten (10) days of
        Licensor's bill therefor.

      

      (k) License
        shall be responsible for the proper storage and removal from the Licensed
        Space
        and the Building and the disposal of all of Licensee's Hazardous Materials.
        Licensee shall contract for the disposal of Hazardous Materials, at Licensee's
        cost and expense, with vendors approved by Licensor, in its sole and absolute
        discretion. In contracting with any such vendor, Licensor shall endeavor
        to
        ensure that Licensee shall receive the benefit of any volume discount granted
        to
        Licensor by such vendor.

      

      11.          
        NO
        LIENS.
        (a)
        Licensee shall have no power to do any act or to make any contract which
        may
        create or give rise to any lien, mortgage or other encumbrance on the estate
        of
        Licensor or any interest of Licensor or Licensee in the Licensed Space or
        the
        Building.

      

      (b) If
        any
        lien shall at any time be filed against the Licensed Space or the Building
        by
        reason of any work, labor, services or materials done for, or supplied to,
        or
        claimed to have been done for, or supplied to, Licensee or anyone holding
        the
        Licensed Space through or under Licensee, Licensee shall cause the same to
        be
        discharged of record or adequately bonded (unless otherwise secured to the
        satisfaction of Licensor) within twenty (20) business days after the date
        Licensee has received notice of the filing of such lien. If Licensee shall
        fail
        to do so, then, Licensor may, but shall not be obligated to, procure the
        discharge of the same either by paying the amount claimed to be due, by deposit
        in a court of competent jurisdiction or by bonding, and Licensor may compel
        the
        prosecution of an action for the foreclosure of such lien by the lienor and
        pay
        the amount of the judgment, if any, in favor of the lienor with interest,
        costs
        and allowances. Any amount paid or deposited by Licensee for any such purpose,
        and all other expenses of Licensor, including reasonable attorney's fees
        and
        disbursements, shall be deemed to be License Consideration and shall be paid
        on
        demand by Licensee.

      
        
          
          

        

        
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      12.           SUBORDINATION.
        Licensee acknowledges that this Agreement is subject and subordinate to any
        and
        all ground or underlying leases and to all mortgages which may now or hereafter
        affect such leases or the Building and to all renewals, modifications,
        consolidations, replacements and extensions of any such underlying leases
        and
        mortgages.

      

      13.          
        NO
        ASSIGNMENT OR USE BY THIRD PARTIES.
        Licensee shall not permit the use or occupancy of all or any part of the
        Licensed Space by any third party nor assign its rights nor delegate its
        duties
        under this Agreement. For purposes of this Paragraph 13, a change in control
        of
        Licensee shall be deemed an assignment hereunder. "Change
        in control"
        shall
        be deemed to mean a change (by transfer or otherwise) in either (a) ownership
        of
        fifty percent (50%) or more of all of the voting stock of a corporation or
        fifty
        percent (50%) or more of all of the legal and equitable interest in a
        partnership or other business entity or (b) the possession of the power directly
        or indirectly to direct or cause the direction of management and policy of
        a
        corporation, partnership or other business entity, whether through the ownership
        of voting securities, by contract common directors or officers the contractual
        right to manage the business affairs of any such corporation, partnership
        or
        business entity, or otherwise.

      

      14.          
        BROKERAGE.
        Licensee represents to Licensor that there is no broker, finder, consultant
        or
        similar person acting on behalf of Licensee entitled to a commission, fee
        or
        other compensation in connection with the consummation of this Agreement
        and no
        conversations or prior negotiations were had by Licensee or anyone acting
        on
        behalf of Licensee with any broker, finder, consultant or similar person
        concerning the use of the Licensed Space except for such broker(s), if any,
        set
        forth in Exhibit
        "G"
        annexed
        hereto and made a part hereof. Licensee hereby agrees to pay the commission
        of
        any such broker, finder, consultant or similar person, Licensee shall indemnify
        and hold Licensor harmless from and against all liability arising from any
        claims for brokerage commissions, finder's fees or other compensation resulting
        from or arising out of any alleged conversations, negotiations or actions
        had by
        Licensee or anyone acting on behalf of Licensee with any broker, finder,
        consultant or similar person. The provisions of this Paragraph 14 shall survive
        the termination of this Agreement.

      

      15.          
        ACCESS
        TO THE PREMISES.
        Licensor and Licensor's agents and employees shall have the right to enter
        the
        Licensed Space for any reasonable purpose, including, without limitation,
        for
        purposes of inspection and repair and monitoring Licensee's activities for
        compliance with the Environmental Legal Requirements, Legal Requirements,
        Insurance Requirements and the Plan. Except in cases of emergency of where
        required for effective inspection and monitoring for health and safety purposes,
        Licensor shall provide Licensee with one (1) day prior notice of its attention
        to enter the Licensed Space, which notice may be given orally or by telephone
        provided that it shall be followed by written notice received by Licensee
        on the
        same day as such oral or telephone notice. License shall acknowledge such
        notice
        "received" by signing a copy thereof and returning it to Licensor within
        twenty-four (24) hours of Licensee's receipt, and Licensor may enter the
        Licensed Space upon receipt of such copy acknowledged by License or upon
        expiration of such 24-hour period, whichever occurs first.

      
        
          
          

        

        
          9

          
            

          

        

        
          
          

        

      

       

      16.           
        INDEMNIFICATION.
        Licensor agrees that Licensee shall make no claim against Licensor for any
        injury or damage to Licensee or to any other person(s) or for any damage
        to, or
        loss (by theft or otherwise) of, any property of Licensee or of any other
        person. Licensee further agrees to indemnify and save Licensor harmless from
        and
        against any and all claims by or on behalf of any person(s), firm(s) or
        corporations(s) arising from the conduct or management of or from any work
        or
        thing whatsoever done in, on or about the Licensed Space during the Term,
        and to
        indemnify and save Licensor harmless from and against any and all claims
        arising
        from any condition of the License Space due to or arising from any act or
        omission or negligence of Licensee or any of its agents, contractors, servants,
        employees, licenses or invitees, and from and against all liabilities, costs
        and
        expenses (including, without limitation, attorneys' fees and disbursements)
        incurred in or in connections with any such claim or claims or action or
        proceeding brought thereon; and in case any action or proceeding shall be
        brought against Licensor by reason of any such claim, Licensee upon notice
        from
        Licensor agrees to resist or defend such action or proceeding and to employ
        counsel therefor reasonably satisfactory to Licensor. The provisions of this
        Paragraph 16 shall survive the termination of this Agreement. 

      

      17.           
        NOTICES.
        All
        notices, demands or requests made pursuant to , under or by virtue of this
        Agreement must be in writing (whether or not so stated) and sent either by
        personal delivery or by nationally recognized overnight carrier service or
        by
        certified or registered mail, return receipt requested, postage prepaid as
        follows:

      

      
        	
                To
                  Licensor:

              	 	
                Executive
                  Director

              
	 	 	
                Audubon
                  Business & Technology Center

              
	 	 	
                3960
                  Broadway

              
	 	 	
                New
                  York, New York 10032

              
	 	 	 
	
                With
                  a copy to:

              	 	
                (i)
                  Columbia University

              
	 	 	
                Office
                  of the General Counsel

              
	 	 	
                412
                  Low Memorial Library

              
	 	 	
                New
                  York, New York 10027

              
	 	 	
                Attention:
                  Deputy General Counsel

              
	 	 	 
	
                and
                  to:

              	 	
                (ii)
                  KMZ Rosenman

              
	 	 	
                575
                  Madison Avenue

              
	 	 	
                New
                  York, New York 10027

              
	 	 	
                Attention:
                  Donald H. Siskind, Esq.

              
	 	 	 
	
                To
                  Licensee:

              	 	
                Neurologix,
                  Inc.

              
	 	 	
                One
                  Bridge Plaza

              
	 	 	
                Fort
                  Lee, NJ 07024

              
	 	 	
                Attention:
                  Mr. Mark Hoffman

              

      

      
        
          
          

        

        
          10

          
            

          

        

        
          
          

        

      

       

      
        	
                With
                  a copy to:

              	 	
                Neurologix,
                  Inc.

              
	 	 	
                221-32
                  E. Grand Central Parkway

              
	 	 	
                Floral
                  Park, NY 11005

              
	 	 	
                Attention:
                  Dr. Martin Kaplin

              

      

      

      or
        to
        such alternative address(es) as may from time to time be designated by notice
        given in the manner provided for in this Paragraph 17. Any such notice, demand
        or request shall be deemed to have been rendered or given on the date or
        delivery, in the case of personal delivery or delivery by overnight courier,
        or
        on the date which is three (3) business days after mailing.

      

      18.           SURRENDER.
        Upon
        the termination of this Agreement, Licensee shall peaceably and quietly leave
        and surrender to Licensor the Licensed Space broom clean, in good order and
        condition, ordinary wear and tear excepted.

      

      19.           SELF-HELP.
        If
        Licensee shall default in the performance of any covenant, provision, agreement
        or condition of this Agreement, and such default shall continue beyond
        applicable notice and grace period, then Licensor, without waiving such default
        and without liability to Licensee, may (but shall not be obligated), perform
        the
        same (and shall have access to the Premises, if necessary, to do so), including,
        without limitation, the making of repairs, for the account and at the expense
        of
        Licensee. Any amounts paid by Licensor in connection with the foregoing,
        shall
        be deemed to be License Consideration payable by Licensee to Licensor within
        ten
        (10) days of Licensor's bill therefor. The rights of Licensor under this
        Paragraph 19 shall be in addition to those set forth in Paragraph
        5(c).

      

      20.          
        TERMINATION.
        (a)
        Licensor may (but shall not be obligated to) terminate this Agreement upon
        five
        (5) days' notice to Licensee if (i) Licensee shall default in the payment
        of the
        License Fee or License Consideration for five (5) days after the due date
        thereof, (ii) Licensee shall be in default hereunder other than a default
        set
        forth in subparagraph (i) of this Paragraph 20, which default shall continue
        and
        shall not be cured for thirty (30) days after notice thereof to Licensee,
        or
        (iii) in the case of a default other than a default set forth in subparagraph
        (i) of this Paragraph 20 which for causes beyond Licensee's control cannot
        with
        due diligence be cured within such 30-day period, if Licensee (1) shall not
        promptly in receipt of such notice advise Licensor of Licensee's intention
        to
        institute all steps necessary to cure such default or (2) shall not institute
        and thereafter with reasonable diligence prosecute to completion all steps
        necessary to cure the same.

      

      (b) Provided
        that Licensee shall surrender and deliver possession of the Licensed Space
        to
        Licensor, and shall not be in default beyond applicable notice and grace
        period
        in performing any term, covenant, provision or condition of this Agreement,
        Licensee may terminate this Agreement with or without cause upon not less
        than
        sixty (60) days' prior written notice to Licensor.

      
        
          
          

        

        
          11

          
            

          

        

        
          
          

        

         

      

      21.          
        SECURITY
        DEPOSIT.
        (a)
        Licensee has deposited the sum of $7,997.00
        with
        Licensor as security for the full and punctual performance by Licensee of
        all of
        the terms of this Agreement, to be deposited by Licensor in an interest-bearing
        account of Licensor's choosing. In the event Licensee defaults in the
        performance of any of the terms of this Agreement, Licensor may use or retain
        the whole or any part of the security deposited to the extent required for
        the
        payment of any fees or for any sum that Licensor may expend or may be required
        to expend by reason of License's default, including any damages or deficiency
        in
        the relicensing or letting of the Licensed Space, whether accruing before
        or
        after summary proceedings or other re-entry by Licensor. In the case of every
        such use or retention, Licensee shall, on demand, pay to Licensor the sum
        so
        used or retained which sum shall be added to the security deposited so that
        the
        same shall be replenished to its former amount. In the event any bankruptcy,
        insolvency, reorganization or other creditor-debtor proceedings shall be
        instituted by or against Licensee, or its successors or assigns, the security
        deposited shall be deemed to be applied first to the payment of such fees
        due
        Licensor for all periods to the institution of such proceedings and the balance,
        if any, of the security deposited may be retained by Licensor in partial
        liquidation of Licensor's damages. If Licensee shall fully and punctually
        comply
        with all of the terms of this Agreement, the security deposited plus any
        accrued
        interest thereon (less an amount equal to one percent per annum on the security
        deposited not to exceed the amount of any interest earned on the security
        deposited for Licensee's administrative costs in connection with the security
        deposited) shall be returned to Licensee after the termination of this Agreement
        and delivery of exclusive possession of the Licensed Space to Licensor in
        compliance with the provisions of this Agreement.

      

      (b) Any
        interest accrued with respect to the security deposited shall be added to
        and
        constitute a part of the security deposited to be held and disposed of by
        Licensor in accordance with the terms of this Paragraph 21. Licensor shall
        not
        be liable to Licensee for any interest except for such interest as is actually
        accrued.

      

      (c) Licensee
        shall, concurrently with the execution and delivery of this Agreement, and
        thereafter at any time upon request by Licensor, deliver to Licensor a fully
        completed Form W-9 (Request for Taxpayer Identification Number and
        Certification).

      

      (d) Licensee
        shall not assign or encumber or attempt to assign or encumber the security
        deposited and neither Licensor nor its successors or assigns shall be bound
        by
        any such assignment, encumbrance or attempted assignment or
        encumbrance.

      

      (e) In
        the
        event of a sale or lease of the Building, Licensor shall have the right to
        transfer the security deposited to the vendee or lessee and Licensor shall
        ipso
        facto
        be
        released by Licensee from all liability for the return of the security deposited
        and Licensee shall look solely to the new licensor for the return of the
        security deposited. The provisions hereof shall apply to every transfer or
        assignment made of the security deposited to a new licensor.

      
        
          
          

        

        
          12

          
            

          

        

        
          
          

        

      

       

      (f) In
        the
        event that the License Fee shall increase pursuant to the terms of this
        Agreement, the amount of security deposited shall be increased so that at
        all
        times the security deposited (exclusive of interest) shall equal one-sixth
        of
        the current annual License Fee. Licensee shall immediately deposit with Licensor
        the difference between the amount required to be deposited pursuant to this
        Subparagraph 21(f)/

      

      22.          
        CAPTIONS.
        The
        captions of the Paragraphs of this Agreement are inserted only as a matter
        of
        convenience and for reference and in no way define, limit or describe the
        scope
        of this Agreement nor the intent of any provision thereof.

      

      23.          
        RELOCATION.
        At any
        time and from time to time during the Term, Licensor shall have the right
        to
        relocate Licensee to space in the Building reasonably comparable in size,
        location and utility for the purposes specified in Paragraph 4 above, upon
        not
        less than sixty (60) days' notice to Licensee.

      

      24.          
        MISCELLANEOUS.
        (a) The
        covenants and agreements contained in this Agreement shall apply to, inure
        to
        the benefit of, and be binding upon Licensor and Licensee and upon their
        respective successors and permitted assigns.

      

      (b) This
        Agreement may not be changed, cancelled or discharged orally, but only by
        an
        agreement in writing and signed by the party against whom enforcement of
        any
        waiver, change, modification or discharge is sought. All understandings and
        agreement between Licensor and Licensee are merged in this Agreement which
        represents the entire agreement between the parties and which fully and
        completely sets forth all terms and conditions of the transactions embodied
        in
        this Agreement.

      

      (c) If
        any
        term or provision of this Agreement or any portion of a term or provision
        of
        this Agreement or the application of any such term or condition to any person
        or
        circumstance shall, to any extent, be invalid or unenforceable, the remainder
        of
        this Agreement, or the application of such term or provision to persons or
        circumstances other than those at to which it is being held invalid or
        unenforceable, shall not be affected and each term and provision of this
        Agreement shall be valid and be enforced to the fullest extent permitted
        by
        law.

      

      (d) This
        Agreement shall be construed in accordance with, and governed by, the laws
        of
        the State of New York applicable to agreements and performed in the State
        of New
        York.

      

      25.          
        NO
        LANDLORD - TENANT RELATIONSHIP.
        Licensee hereby acknowledges that Licensees acquires no rights as a tenant
        of
        the Licensed Space and that no landlord-tenant relationship is created
        hereby.

      

      26.          
        JURISDICTION.
        Licensee acknowledges and agrees that all disputes arising, directly or
        indirectly, out of or relating to this Agreement, and all actions to enforce
        this Agreement, may be dealt with and adjudicated in the state courts of
        New
        York or the federal courts sitting in New York and Licensee hereby expressly
        and
        irrevocably submits the person of Licensee to the jurisdiction of such courts
        in
        any suit, action or proceeding arising, directly or indirectly, out of or
        relating to this Agreement and hereby irrevocably designates the Secretary
        of
        State of New York as its agent for service of process in any such suit, action
        or proceeding.

      
        
          
          

        

        
          13

          
            

          

        

        
          
          

        

      

       

      IN
        WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly
        executed as of the day and year first above written.

    

     

    
      	 	 	THE TRUSTEES OF COLUMBIA UNIVERSITY
              IN THE
              CITY OF NEW YORK,
              Licensor
	 	 	 
	 	 	By: /s/
              Kevin E. Kirby
	 	 	Title: Kevin
              E. Kirby, VP for Administration
	 	 	 
	 	 	Neurologix, Inc.   ,
              Licensee
	 	 	 
	 	 	By: /s/
              Mark Hoffman
	 	 	Title: Secretary
              and Treasurer

    

    
       

       

       

      
        14Exhibit 10.21

    
      

    

     

    
      Neurologix,
        Inc.

      271-32E
        Grand Central Parkway

      Floral
        Park, New York 22005

      

      

      February
        19, 2004

      

      Mr.
        Mark
        Hoffman

      Palisade
        Capital Securities, L.L.C.

      One
        Bridge Plaza

      Fort
        Lee,
        New Jersey 07024

      

      Dear
        Mr.
        Hoffman:

      

      This
        will
        confirm that we have requested you to provide us with various investment
        banking
        and financial advisory services in connection with our merger with CTP/N
        Merger
        Corp., a wholly-owned subsidiary of Change Technology Partners, Inc., whereby
        we
        will acquire approximately 68% of the outstanding common stock of the combined
        company. This will also confirm our understanding that we have agreed to
        pay you
        a fee of $200,000 in connection with such services; provided however; that
        such
        consideration is contingent upon, and only shall be payable, if the merger
        is
        successfully consummated.

      

      We
        appreciate your assistance in this matter. 

      

      Very
        truly yours,

      

      /s/
        Dr. Martin J. Kaplitt, President

      Dr.
        Martin J. Kaplitt, President

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