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                                                                    EXHIBIT 4.13

                                AMENDMENT NO. 5

                                       TO

                         REGISTRATION RIGHTS AGREEMENT

     AMENDMENT NO. 5, dated as of January 10, 2000 by and among Adolor
Corporation, a Delaware corporation (the "Company"), certain holders of the
Company's outstanding securities (collectively, the "Existing Investors") and
those purchasers listed in Schedule Ito the Series G Convertible Preferred Stock
Purchase Agreement (the "Purchase Agreement") dated the date hereof
(collectively, including such purchasers who participate in any Additional
Closing (as defined in the Purchase Agreement) and who execute a counterpart to
this Agreement, the "Purchasers").

     WHEREAS, the Company and the Existing Investors are parties to that
Registration Rights Agreement (the "Registration Rights Agreement") by and among
the Company and the parties named therein dated as of the 7th day of November
1994, as amended by Amendment No. 1 to the Registration Rights Agreement dated
as of February 27, 1996, Amendment No. 2 to the Registration Rights Agreement
dated as of May 1, 1997, Amendment No. 3 to the Registration Rights Agreement
dated as of December 8, 1998, and Amendment No. 4 to the Registration Rights
Agreement dated as of July 22, 1999; and

     WHEREAS, the Purchasers are purchasing from the Company and the Company is
issuing and selling to the Purchasers up to 12,306,000 shares (the "Series G
Shares") of Series G Convertible Preferred Stock, par value $.01, ("Series G
Stock") of the Company at the aggregate purchase price of up to $12,306,000
pursuant to the Purchase Agreement, and

     WHEREAS, it is a condition to the sale of the Series G Shares that the
Registration Rights Agreement be amended to grant the Purchasers certain rights
thereunder, and the parties hereto desire to amend the Registration Rights
Agreement as set forth below

     NOW, THEREFORE in consideration of the foregoing and the promises and
covenants contained herein, the parties hereby agree as follows:

1.   That Section 1 of the Registration Rights Agreement, as amended to date, be
     and hereby is further amended to delete the definition of "Preferred
     Shares" therein and replace it with the following:

         "Preferred Shares" shall mean shares of the Company's Series A
         Convertible Preferred Stock, par value $.01 per share, Series B
         Convertible Preferred Stock, par value $.01 per share, Series C
         Convertible Preferred Stock, par value $.01 per share, Series E
         Convertible Preferred Stock, par value $.01 per share, Series F
         Convertible Preferred Stock, par value $.01 per share, and Series G
         Convertible Preferred Stock, par value $.01 per share.

2.   That any Purchasers who have not previously been made parties to the
     Registration Rights Agreement, as amended, shall become parties to the
     Registration Rights Agreement, as amended; and that any Existing Investors
     who have not previously been
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     made parties to the Registration Rights Agreement, as amended, shall become
     parties to the Registration Rights Agreement, as amended.

3.   Capitalized terms used but not otherwise defined herein shall have the
     meanings ascribed to them in the Registration Rights Agreement.

4.   In all other respects, the Registration Rights Agreement is hereby
     ratified, confirmed and approved, and all terms thereof shall remain in
     full force and effect.

5.   This Amendment No. 5 may be executed in counterparts, each of which shall
     constitute an original, but all of which, when taken together, shall
     constitute but one agreement.

                      [Signature Pages Follow Immediately]<PAGE>   1

                                                                    EXHIBIT 10.2

                       AMENDMENT TO EMPLOYMENT AGREEMENT

     This Amendment to Employment Agreement is entered into as of the 22nd day
of October, 1999, between THE DIME SAVINGS BANK OF NEW YORK, FSB (the "Bank"), a
federal stock savings bank having its principal executive offices at 589 Fifth
Avenue, New York, New York 10017, and LAWRENCE J. TOAL (the "Officer").

     A. The parties hereto have previously entered into an Employment Agreement
dated as of January 30, 1998 (the "Employment Agreement").

     B. Dime Bancorp, Inc. (the "Company") and Hudson United Bancorp ("Hudson")
have entered into an Agreement and Plan of Merger dated as of September 15, 1999
(the "Merger Agreement"), which contemplates the merger or business combination
of Hudson and the Company (the "Holding Company Combination") at the Effective
Time (as defined in the Merger Agreement) as well as the merger or business
combination of the Bank and Hudson United Bank (the "Bank Combination").

     C. The Bank is desirous, pursuant to the Merger Agreement, of providing for
the continued employment of the Officer subsequent to the Effective Time by the
Surviving Corporation (as defined in the Merger Agreement) and of the entity
resulting from the Bank Combination (the "Surviving Bank") and upon the terms
and conditions set forth in this Agreement.

     D. The Officer is desirous of continuing such employment upon the terms and
conditions set forth in this Agreement.

     1. Section 2(a) of the Employment Agreement shall be amended to delete the
existing text thereof in its entirety and insert in its place the following:

          "The term of the Officer's employment under this Agreement shall be
     deemed to have commenced on the date of this Agreement and shall continue
     until December 31, 2002 (the "Term").

     2. Section 3 of the Employment Agreement shall be amended as follows:

          (a) By inserting in the first sentence thereof, after the words
     "During the Term," and before the words "the Officer shall serve" the words
     "and until the Effective Time".

          (b) By adding after the first sentence thereof the following:

             "Beginning at the Effective Time and for the remainder of the Term,
        the Officer shall serve as Chairman of the Board and Chief Executive
        Officer of the Company, and as Chairman of the Board and Chief Executive
        Officer of the Bank, and as Chairman of the Executive Committee of the
        Board of Directors of each of the Company and the Bank; provided, that
        the Officer shall cease to hold such positions effective on December 31,
        2002. In addition, beginning on the Effective Date and for the remainder
        of the Term, the Officer shall serve as a director of each of the
        Company and the Bank."

          (c) By adding as a new last sentence thereof the following:

             "Upon and following the respective effective times of the Holding
        Company Combination and the Bank Combination, all references in this
        Agreement to the "Company" and the "Bank" shall be deemed to refer to
        the Surviving Corporation and the Surviving Bank, respectively."
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     3. Section 4 of the Employment Agreement shall be amended to delete the
first sentence thereof and to insert in its place the following:

          "The Officer shall perform such duties as reasonably and customarily
     pertain to the offices set forth in Section 3 and such other duties as are
     set forth in the Bylaws of the Company and the Bank or as may be agreed to
     from time to time by the Officer."

     4.  A new Section 5(f) shall be added to the Employment Agreement, as
follows:

          "(f) Immediately following the Effective Time, subject to the
     discretion and approval of the Compensation Committee, the Board of
     Directors or other appropriate Committee of the Board of Directors, the
     Company shall grant to the Officer options to purchase 150,000 shares of
     the Company's common stock at the closing market price thereof; provided,
     that such options shall vest in accordance with the following schedule: (i)
     one-third on the first anniversary of the date of grant (provided the
     Officer continues to hold the offices of Chairman of the Board and Chief
     Executive Officer of the Company on such date); (ii) one-third on the
     second anniversary of the date of grant (provided the Officer continues to
     hold such offices on such date); and (iii) one-third on December 30, 2002
     (provided the Officer continues to hold such offices on such date). Such
     options shall be granted subject to the terms and conditions (including
     accelerated vesting) of the Company's stock incentive plan under which they
     are issued, and such other terms as are set by the granting committee and,
     as appropriate, the Board of Directors, in accordance with such Plan."

     5.  A new Section 5(g) shall be added to the Employment Agreement, as
follows:

          "(g) (i) Each stock option hereafter granted for Company stock to the
     Officer (including, without limitation, the stock options provided for in
     Section 5(f) hereof) shall (to the extent permitted by the plan under which
     such stock option is granted), upon vesting, remain exercisable for the
     full term thereof, without reduction of such term on account of termination
     of employment (other than for cause), retirement, disability or death (or
     any other events, such as loss of office, that are directly related
     thereto) (each, a "Termination Event"), provided, that such options shall
     otherwise be subject to all of the other terms and conditions set forth in
     the applicable grant letter.

           (ii) At the Effective Time, each stock option for Company stock
     (including any tandem stock appreciation right) granted to the Officer
     prior to the Effective Time (other than stock options to which Section
     5(g)(i) hereof apply) shall, upon vesting, to the extent permitted by the
     plan under which such stock option was granted but notwithstanding anything
     to the contrary in the grant letter related to such stock option,
     thereafter remain exercisable for the term specified in such grant letter
     without reduction of such term on account of any Termination Event, but
     otherwise subject to all of the other terms and conditions of such
     applicable grant letter."

     6. Section 7 of the Employment Agreement shall be amended as follows:

          (a) The existing provisions of Section 7 shall be retained and shall
     be designated paragraph (a) thereof;

          (b) By deleting the figure "50%" in the first sentence of such Section
     7(a) and inserting in its place the figure "60%".

          (c) There shall be added thereto the following Section 7(b):

             "(b) Notwithstanding anything in paragraph (a) of this Section 7 to
        the contrary, the Company shall pay to the Officer, for each calendar
        year or portion thereof during the Officer's remaining life following
        the later of the date the Officer attains age 65, or the date his
        employment by the Company and the Bank terminates, an amount equal to
        the difference, if any, between (i) $1,235,000 (prorated for any
        applicable periods of less than one year) less (ii) the sum of (A) all
        benefits payable to the Officer under the SERP with respect to such year
        or

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        period or otherwise pursuant to Section 7(a), presuming an effective
        election to commence SERP benefits (or other benefits pursuant to
        Section 7(a)) at the same time as benefits under this paragraph (b) had
        been made (whether or not such SERP (or other Section 7(a)) benefits are
        actually being paid on such date), plus (B) the amount of any benefits
        which the Officer is entitled to receive for such year or period under
        any defined benefit plan qualified under Section 401(a) of the Code
        sponsored by the Company, any Affiliate (as defined in Section 12(a)) or
        any predecessor or successor to any of them (the "Retirement Plans")
        plus (C) the amount of any benefits which the Officer is entitled to
        receive for such year or period under any defined benefit excess benefit
        or benefit restoration plan of the Company, any Affiliate or any
        predecessor or successor to any of them, plus (D) the amount of any
        benefits which the Officer is entitled to receive for such year or
        period under any other plan, agreement or arrangement maintained by the
        Company, any Affiliate or any predecessor or successor to any of them
        that determines benefit amounts with relation to one or more Retirement
        Plans, plus (E) the amount of any benefits which the Officer is then
        entitled to receive for such year (or, if the amount specified in clause
        (i) is to be prorated for a specified period, for the same period) under
        Section 6 of this Agreement. In determining the amount so payable, any
        benefits described in clause (ii) of the preceding sentence (other than
        subclause (E) thereof) that are not payable in the form of a single life
        annuity commencing at the same time as benefits hereunder shall, solely
        for purposes of the preceding sentence, be converted, on an actuarial
        equivalent basis, to a single life annuity form of payment commencing on
        the same date as the benefits pursuant to this paragraph (b) with
        actuarial equivalence to be determined based on the factors used to
        determine actuarial equivalence under the SERP. The amount so determined
        to be payable pursuant to this paragraph (b) shall be paid on the same
        basis as payments under the SERP (including actuarial reductions with
        respect to alternative forms of benefit thereunder, and the SERP's
        provisions regarding preretirement survivor benefits), and the Officer
        shall have the same election rights with respect thereto, regardless of
        whether or not any amounts are then being paid under the SERP."

     7. Section 9(e) shall be amended to delete the existing text thereof in its
entirety and insert in its place the following:

          "Unless this Agreement shall have previously been terminated pursuant
     to the terms hereof, then upon the expiration of the Term on December 31,
     2002, the employment of the Officer hereunder shall terminate and the
     Officer shall not be entitled to any additional compensation or benefits as
     a result of such expiration pursuant to this Section 9 or Section 12."

     8. Section 12(g)(i) shall be amended so that each reference therein to
"SERP benefits" shall be changed to read "SERP and other related benefits."

     9. Section 16 shall be amended by adding the following at the end thereof:
"This Agreement shall be subject to, and the Officer shall be entitled to the
benefits of, the applicable provisions of Sections 3.3 and 3.4 of the Merger
Agreement."

     10. In consideration of the rights and benefits granted under this
Amendment, the Officer hereby irrevocably waives any right he may otherwise to
additional benefits based on a claim that the provisions of Section 2 of this
Amendment or the effectuation thereof constitute or will constitute a "Material
Change" as defined in and for purposes of the Employment Agreement.

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     11. The Company hereby joins in this Amendment for purposes of confirming
that the Agreement dated as of January 30, 1998 between the Company and the
Officer shall, as modified hereby, remain in full force and effect and that each
reference therein to the "Employment Agreement" shall be deemed to mean the
Employment Agreement as modified and amended by this Amendment.

                                          THE DIME SAVINGS BANK
                                          OF NEW YORK, FSB

                                          By /s/ IRA T. WENDER
                                            ------------------------------------
                                          Name: Ira T. Wender
                                          Title:  Director and
                                                  Chairman -- Compensation
                                                  Committee

                                          /s/ LAWRENCE J. TOAL
                                          --------------------------------------
                                             LAWRENCE J. TOAL

                                          DIME BANCORP, INC.

                                          By /s/ IRA T. WENDER
                                            ------------------------------------
                                          Name: Ira T. Wender
                                          Title:  Director and
                                                  Chairman -- Compensation
                                                  Committee

Dated: December 21, 1999

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