Document:

EX-10.1

 Exhibit 10.1 

THIS AMENDMENT NO. 1 TO THE DEED OF ADHERENCE (the “Amendment”) is made the 28th day of March 2013 

BETWEEN: 
  

	(1)	BGC SERVICES (HOLDINGS) LLP, (the “Partnership”), of One Churchill Place London E14 5RD; and 

 

	(2)	SHAUN D. LYNN (the “FURTHER MEMBER”), 

 and in favour of each Member of the Partnership and the Partnership for itself. 
 BACKGROUND /
JOINT RECITAL: 
 IT IS HEREBY AGREED as follows: 
  

	(A)	By a Limited Liability Partnership Deed, the Partnership was established on 21 December 2011, the Members (as defined therein) agreed to regulate their relations
as Members of the Partnership. 

  

	(B)	On 21 December 2012 the Members amended and restated the Limited Liability Partnership Deed (“Partnership Deed”) in contemplation of Further Members (as
defined therein) joining the Partnership in the capacity of Individual Members subject at all times to the Board’s (as defined in the Partnership Deed) absolute discretion. 

 

	(C)	On 7 January 2013, the Further Member entered into a Deed of Adherence to the Partnership Deed (the “January Deed”). 

 

	(D)	No notice of termination has been given by either the Partnership or the Further Member pursuant to the Partnership Deed or the January Deed. The parties hereto seek to
agree to certain amendments of the notice provisions set forth in Schedule 1 to the January Deed as set forth below. 

 IT IS
FURTHER HEREBY AGREED as follows: 
  

	1	Interpretation 

  

	1.1	Save where the context otherwise requires, the words and expressions used in this Amendment shall have the meanings respectively assigned to them in the Partnership
Deed and/or the January Deed, as the case may be. 

  

	1.2	The Schedule 1 to the January Deed shall be deemed incorporated into this Amendment as if repeated herein in full and such Schedule 1 shall be amended as set forth
below. 

  

	2	Adherence to Partnership 

  

	2.1	Pursuant to Section 2.4 of the January Deed, Schedule 1 is hereby amended as follows, which amendment is hereby approved by agreement of both the Partnership
(acting through the Board) and the Further Member in accordance with this Amendment and in his capacity as an Individual Member: 

 A. Item 1.1 of Schedule 1 to the January Deed shall be superseded in
its entirety with the following: 
 1.1. Subject to the other provisions in this Deed and the Partnership Deed (including without
limitation, clause 7.1), Membership shall continue until terminated in accordance with Item 4.1 of Schedule 1 to the January Deed. 
 B. Item 4.1 of Schedule 1 to the January Deed shall be superseded in its entirety with the following: 
 4.1. Either the Individual Member or the Partnership may at any time give twelve (12) months’ notice (the “Notice Period”) to the other in writing to terminate the Individual
Member’s Membership, and such termination shall be effective upon the completion of such Notice Period. Any such notice given by the Individual Member or the Partnership hereunder shall also be delivered simultaneously in writing by the
Individual Member or Partnership (as appropriate) to BGC Partners, Inc., c/o General Counsel, 499 Park Avenue, New York, NY 10022. Such notice shall be delivered by hand, electronic mail or overnight courier and shall be effective at such time as it
is received by both the Individual Member or the Partnership, as the case may be, and by BGC Partners, Inc. 

C. The new Clause 14.6 (Consequences of Removal) added at Item 8.2 of Schedule 1 to the January Deed shall be
superseded in its entirety with the following: 
 “14.6 Consequences of Removal 

In the event that an Individual Member gives notice to withdraw from Membership or otherwise seeks to leave the Partnership, the Board
may, in its discretion, at any time require an Individual Member to remain at home and/or be under no obligation to assign any duties or provide any work for him or transfer the Individual Member to a different product area (“Garden
Leave”). The terms applicable to the Individual Member during any period of Suspension or Garden Leave shall include the provisions of clause 14.5 of the Deed save to the extent varied by instructions given under this clause 14.6. 

For the avoidance of doubt, during any period of Garden Leave an Individual Member shall continue to receive his Allocated Monthly Advance
Drawings and, save to the extent varied by Clause 8.3 below, such further profit allocation that would otherwise have been due under Clause 3 above but for such Garden Leave.” 

 

	2.2	This Amendment shall be supplemental to and read together with the Partnership Deed and the January Deed. In the case of a conflict between any of the provisions of
this Amendment and the Partnership Deed or the January Deed, this Amendment shall take precedence as between the Partnership and the Further Member. 

 IN WITNESS WHEREOF the parties have executed this Amendment the day and year first above written. 
  

					
	 SIGNED and DELIVERED as a
	 	)	  	
	 DEED by BGC SERVICES 
	 	)	  	
	 (HOLDINGS) LLP acting by:
	 	):	  	
			
		 	 /s/ Mark Cooper
	  	
		 	(—)	  	
			
	 SIGNED and DELIVERED as a
	 	)	  	
	DEED by SHAUN D. LYNN	 	)	  	
	acting by:	 	):	  	
			
		 	 /s/ Shaun D. Lynn
	  	
		 	(—)EX-10.1

					
	

	 	  
 DEPARTMENT OF HEALTH & HUMAN SERVICES
  
	  	 Exhibit 10.1

 
 Office of the Secretary

 

	 		  	 Office of the Assistant Secretary for
 Preparedness & Response
 Washington, D.C. 20201

 

 26 March 2013 
 Ray Taylor 
 VP Program Management 
 BioCryst Pharmaceuticals, Inc. 
 4505 Emperor Boulevard, Suite 200 

Durham, NC 27703 
 Subject: Stop Work Order,
Contract No. HHSO100200700032C 
 Dear Mr. Taylor: 
 In accordance with FAR Part 42.1303 and FAR Part 52.242-15, the Department of Health and Human Services (HHS) hereby directs BioCryst Pharmaceuticals, Inc. to stop-work on contract number
HHSO100200700032C and only perform the activities as listed below: 
  

	 	•	 	 Stability testing for stockpiled peramivir 

  

	 	•	 	 Complete study 301 study report 

  

	 	•	 	 Complete study 301 pharmacokinetic testing 

  

	 	•	 	 Closeout activities associated with termination of study 301, Completion of study 110 Clinical Study Report 

 

	 	•	 	 Preparation for type C meeting and In-Process Review (IPR), including assembly of FDA data package 

 

	 	•	 	 Clinical/Regulatory support for wind-down activities associated with closure of clinical sites and study termination, data monitoring and cleansing and
activities associated with preparation for type C meeting and IPR 

  

	 	•	 	 Continuation and completion of COA-approved virology and resistance testing 

 BARDA will continue to support the above activities as already described in the contract which are necessary to achieve the immediate milestones. These activities will be supported through the type C
meeting which is scheduled for April 1, 2013 and the IPR which is tentatively scheduled three (3) weeks afterwards. Once the IPR is conducted, the Milestone Decision Authority (MDA) will make a decision on a path forward. Therefore,
BioCryst shall cease all services in support of the subject contract, with the exception of the activities listed above, and shall cease incurring any costs for those services Including but not limited to BioCryst’s indirect costs. Any and all
subcontractors shall be notified immediately that a stop-work order has been issued to the prime contractor. 
 The stop-work order shall remain
in place until June 5, 2013. As soon as feasible and prior to the expiration of the stop-work order, appropriate action shall be taken to terminate the contract; cancel the stop-work order; or extend the period, if necessary. 

Should BioCryst require additional information In regards to this stop-work order, please contact the undersigned via email at kim.morris@hhs.gov

 Sincerely, 
 Kim Morris 

Contracting Officer 
 HHS/OS/ASPR/AMCG

  

					
	

	 	DEPARTMENT OF HEALTH & HUMAN SERVICES	  	 Office of the Secretary

 

	 		  	 Office of the Assistant Secretary for
 Preparedness & Response
 Washington, D.C. 20201

 

	Cc:	Kevin Gilligan, Project Officer 

Mike Wathen, Chief, Influenza Antiviral Branch 
 Robert Huebner, Director, Influenza DivisionEX-10.1

 Exhibit 10.1 
 THIRD AMENDMENT TO LEASE 
 THIS THIRD AMENDMENT TO LEASE (this
“Amendment”) is dated for reference purposes as of April 1, 2013 and is entered into by and between DWF III GATEWAY, LLC, a Delaware limited liability company (“Landlord”) and OXIGENE, INC., a Delaware
corporation (“Tenant”). 
 R E C I TA L S 

A. Landlord (as successor-in-interest to Broadway 701 Gateway Fee LLC, a Delaware limited liability company) and Tenant are parties to
that certain Office Lease 701 Gateway dated as of October 10, 2008, as amended by that certain First Amendment to Lease dated as of November 27, 2012, and as amended by that certain Second Amendment to Lease dated as of January 30,
2013 (collectively, the “Original Lease”), pursuant to which Tenant leases certain premises containing approximately Five Thousand Two Hundred Seventy-Five (5,275) rentable square feet of space commonly known as Suite 270 (the
“Premises”) located in the building having an office address of 701 Gateway Boulevard, South San Francisco, California (the “Building”). 
 B. Landlord and Tenant now desire to amend the Original Lease to extend the Term, subject to each of the terms, conditions, and provisions set forth herein. 

A G R E E M E N T 
 NOW THEREFORE, in consideration of the agreements of Landlord and Tenant contained herein and other valuable consideration, the receipt and adequacy of which are hereby acknowledged, Landlord and Tenant
agree as follows: 
  

	1.	RECITALS 

 Landlord and
Tenant acknowledge and agree the above recitals are true and correct and are hereby incorporated herein as though set forth in full. 
  

	2.	DEFINITIONS 

 As of the
date hereof, unless context clearly indicates otherwise, all references to “the Lease” or “this Lease” in the Original Lease or in this Amendment shall be deemed to refer to the Original Lease, as amended by this Amendment.
Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Original Lease unless context clearly indicates otherwise. 
  

	3.	EXTENDED TERM 

 The
parties acknowledge that the Lease Term is scheduled to expire on June 30, 2013. Notwithstanding the foregoing, the Lease Term is hereby extended such that the Expiration Date shall be June 30, 2014. Tenant acknowledges that it has no
right to further renew or extend the Lease Term. 

	4.	BASE RENT 

 Effective as
of July 1, 2013 and continuing through the Expiration Date, the monthly Base Rent payable by Tenant to Landlord for the Premises pursuant to Article 3 of the Original Lease shall be payable in the amount of Sixteen Thousand Six Hundred Sixteen
and 25/100 Dollars ($16,616.25). 
  

	5.	BASE YEAR 

 Effective as
of July 1, 2013, the Base Year shall be the calendar year 2013. 
  

	6.	SECURITY DEPOSIT 

 As of
the date of this Amendment, the Security Deposit (which the parties agree is currently $86,079.54) shall be reduced by $52,847.04, such that the total amount of the Security Deposit held by Landlord shall be Thirty-Three Thousand Two Hundred
Thirty-Two and 50/100 Dollars ($33,232.50). Accordingly, following the execution of this Amendment, Landlord shall deliver to Tenant the sum of $52,847.04. 
  

	7.	CONDITION OF PREMISES 

Tenant acknowledges that it has been, and continues to be, in possession of the Premises, is familiar with the condition of the Premises
and continues to occupy the Premises in its “as is, where is” condition, with all faults, without any representation, warranty or improvement by Landlord of any kind whatsoever. 

 

	8.	MISCELLANEOUS 

 (a) As
amended hereby, the Original Lease is hereby ratified and confirmed in all respects. In the event of any inconsistencies between the terms of this Amendment and the Original Lease, the terms of this Amendment shall prevail. 

(b) Tenant represents and warrants to Landlord that neither it nor its officers or agents nor anyone acting on its behalf has dealt with
any real estate broker or finder in the negotiating or making of this Amendment, other than Cassidy Turley. Tenant shall indemnify, defend and hold Landlord harmless from any claim or claims, and costs and expenses, including attorneys’ fees,
incurred by Landlord in conjunction with any claim or claims of any other broker or brokers to a commission in connection with this Amendment as a result of the actions of Tenant or its officers, agents or anyone acting on its behalf. 

(c) This Amendment shall bind and inure to the benefit of Landlord and Tenant and their respective legal representatives and successors
and assigns. 
 (d) This Amendment may be executed in counterparts each of which counterparts when taken together shall
constitute one and the same agreement. 
 (e) The preparation and submission of a draft of this Amendment by either party to the
other shall not constitute an offer, nor shall either party be bound to any terms of this 

  
 2 

 
Amendment or the entirety of the Amendment itself until both parties have fully executed a final document and an original signature document has been received by both parties. Until such time as
described in the previous sentence, either party is free to terminate negotiations with no obligation to the other. 
 (f)
Except as set forth in this Amendment, all terms and conditions of the Original Lease shall remain in full force and effect. 

Remainder of Page Intentionally Blank 

  
 3 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the date first
above written. 
  

									
		 	LANDLORD:	 	 DWF III GATEWAY, LLC,
 a Delaware limited Liability Company

				
		 		 	By:	 	Divco West Real Estate Services, Inc.
		 		 		 	 a Delaware corporation
 Its Agent

					
		 		 		 	By:	 	 /s/ James Teng

		 		 		 	Name:	 	 James Teng

		 		 		 	Title:	 	 Managing Director

			
		 	TENANT:	 	 OXIGENE, INC.,
 a
Delaware corporation

				
		 		 	By:	 	 /s/ Peter J. Langecker

		 		 	Name:	 	 Peter J. Langecker

		 		 	Title:	 	 CEO

  
 4

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