Document:

<PAGE>
                                                                    Exhibit 10.3

                      AMENDED AND RESTATED VOTING AGREEMENT

      THIS AMENDED AND RESTATED VOTING AGREEMENT is dated as of March 29, 2005
by and among Molecular Insight Pharmaceuticals, Inc., a Massachusetts
corporation (the "Company"), the holders of the Company's Series A Convertible
Preferred Stock set forth on the signature page hereto (the "Series A Holders"),
the holders of the Company's Series B Convertible Preferred Stock set forth on
the signature page hereto (the "Series B Holders"), the holders of the Company's
Series C Convertible Preferred Stock set forth on the signature page hereto (the
"Series C Holders"), and certain holders of the Company's Common Stock as set
forth on the signature page hereto (the "Common Stockholders" and together with
the Series C Holders, Series B Holders and the Series A Holders, the
"Stockholders").

      WHEREAS, the Company and certain holders of its Common Stock, Series A
Convertible Preferred Stock and Series B Convertible Preferred Stock previously
entered into a Voting Agreement dated March 4, 2004 (the "Prior Agreement")
which provided, inter alia, for certain voting agreements relating to the
election of members to the Company's Board of Directors (the "Board of
Directors"); and

      WHEREAS, the Company desires to sell to the Series C Holders, and the
Series C Holders desire to purchase, shares of Series C Convertible Preferred
Stock ("Series C Preferred Stock") and, as a condition to such purchase and
sale, the Series C Holders require certain changes to the Prior Agreement.

      NOW, THEREFORE, in consideration of the mutual covenants and agreements
contained herein and the investment by the Series C Holders under that certain
Stock Purchase Agreement (as defined below), the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

      Section 1. Election of Directors. At any time at which stockholders of the
Company have the right to, or vote for or consent in writing to, the election of
directors of the Company, the Stockholders hereby agree to vote, or consent in
writing as to, all shares of capital stock of the Company then owned by them in
favor of the following actions to:

            (a) cause the election to the Board of Directors of one (1)
representative designated by David Barlow ("Series A Director"), who shall
initially be David Barlow; provided, however that if David Barlow is removed as
the Series A Director for cause (as defined in Section 1(h) below) then the
Series A Director shall be designated by the Series A Holders holding a majority
of the shares of the Series A Convertible Preferred Stock; and

            (b) cause the election to the Board of Directors of one (1)
representative designated by Cerberus Partners, L.P. (the "Series B Director"),
who shall initially be Daniel Frank and who shall thereafter be selected by
Cerberus Partners, L.P.; and

<PAGE>

            (c) subject to clause (i) below, cause the election to the Board of
Directors of one (1) representative designated by Cerberus Partners, L.P. (the
"Series C Director" and, together with the Series A Director and the Series B
Director, the "Investor Directors"), who shall initially be Andrew Jay; and

            (d) cause the election to the Board of Directors of one (1) member
who shall be the President of the Company (the "Management Director"), who shall
initially be John Babich; provided that if the Company shall not have a
President, such position held by the Chief Executive Officer of the Company or,
if there is no President or Chief Executive Officer then serving for the
Company, such individual serving in a similar capacity; and

            (e) cause the election to the Board of Directors of three (3)
members with appropriate industry experience who shall be designated by the
President of the Company in consultation with the senior management of the
Company and approved by the Series B Director, which approval shall not be
unreasonably withheld or delayed (the "Industry Directors"), who shall initially
be Harry Stylli, Kim Lamon and William Eckelman.

            (f) The Company shall cause the nomination for election to the Board
of Directors of the individuals set forth in clauses (a) through and including
(e) above. Each of the directors designated in this Section 1 shall be elected
at any annual or special meeting of stockholders (or by written consent in lieu
of a meeting of stockholders) and shall serve until his or her successor is
elected and qualified, or until his or her earlier resignation or removal.

            (g) The Board of Directors shall remain seven (7) members unless
changed by the vote or written consent of (i) the holders of at least fifty
percent (50%) of the then-outstanding shares of capital stock, with all classes
voting together as a single class, (ii) the holders of at least fifty percent
(50%) of the Series A Convertible Preferred Stock, (iii) the holders of at least
fifty percent (50%) of the Series B Convertible Preferred Stock and (iv) the
holders of at least fifty percent (50%) of the Series C Preferred Stock (the
vote or consent required by clauses (i) through (iv) being the "Requisite
Vote").

            (h) For purposes of Section 1(a), "cause" shall mean either (i) the
conviction of, or pleading of nolo contendre to, a felony or (ii) the commission
of an act of fraud or embezzlement, in each case, by David Barlow.

            (i) So long as Siemens Venture Capital GmbH ("Siemens") continues to
own Series C Preferred Stock having an aggregate Series C Stated Value of at
least Three Million Dollars ($3,000,000), Siemens shall be entitled to appoint
the Series C Director (when so appointed by Siemens, the Series C Director shall
be referred to as the "Siemens Director"); provided, however, that, upon a
Removal Event, Siemens shall immediately cease to have the right to appoint the
Series C Director and the Siemens Director shall be automatically and
immediately, without the need for any further corporate or Board of Directors
action or deed, removed from the Board of Directors. In the event of the
occurrence of a Removal Event

                                       -2-
<PAGE>

described in clause (i) of the definition of Removal Event only, Siemens shall
once again have the right of appointment of the Series C Director if the Board
of Directors, acting at a duly called meeting and/or by written consent, adopts
a resolution abandoning, canceling or ending the Removal Event. This right to
appoint the Series C Director is personal to Siemens and, notwithstanding
anything to the contrary herein or in any of the Transaction Documents (as
defined in the Stock Purchase Agreement), such right shall not be assignable by
Siemens, including without limitation, to any transferee of Series C Preferred
Stock (or the Common Stock issuable upon conversion thereof) by Siemens. If the
Siemens Director shall be removed from the Board of Directors pursuant to a
Removal Event as set forth in this clause (i), the Company shall provide the
Siemens Director with prompt written notice thereof (without any obligation to
disclose the details of the applicable Removal Event), but the failure to give
any such notice shall not be a condition to, or otherwise serve as a basis to
prevent, any such removal. For purposes of Sections 1 and 3 herein, the
following definitions shall apply:

            (1) "Co-Lead Investors" shall mean Cerberus Partners, L.P. and
MedCap Partners, L.P.

            (2) "Qualified Public Offering" shall mean the closing of a firm
commitment underwritten public offering of shares of the Company's Common Stock
pursuant to a registration statement filed with the Securities and Exchange
Commission under the Securities Act of 1933, as amended, on form S-1 or its
equivalent, in which the Company's Common Stock is offered and sold to the
public at an initial public offering price equal to at least $5.00 per share,
with aggregate gross proceeds to the Company of not less than $30 million.

            (3) "Removal Event" shall mean the soonest to occur of: (i) the
adoption of a resolution by the Board of Directors, acting at a duly called
meeting and/or by written consent, taking any action to pursue consideration of
any merger, consolidation, sale, lease or exchange of substantially all of its
assets, sale or exchange of its capital stock, or any other similar business
transaction involving the Corporation; (ii) June 30, 2007; and (iii) a Qualified
Public Offering.

            (4) "Series C Stated Value" shall mean, with respect to each shares
of Series C Preferred Stock, $202.00, which amount shall be subject to
appropriate adjustment in the event of a stock dividend, stock split, reverse
stock split, reclassification, stock combination or other recapitalization
affecting the Series C Preferred Stock, all in accordance with the Company's
Articles of Organization, as amended to date.

            (5) "Stock Purchase Agreement" shall mean that certain Stock
Purchase Agreement by and between the Company and the Series C Holders dated
March 29, 2005.

      Section 2. Vacancies and Removal.

            (a) Series A Director. The Series A Director may be removed during
his or her term of office, with or without cause, by and only by the affirmative
vote or written consent

                                       -3-
<PAGE>

of the holders of a majority of the then-outstanding shares of Series A
Convertible Preferred Stock. Each of the Stockholders agrees to, and shall, vote
all of its shares of capital stock in the same manner as the vote cast or
consent given by the holders of the majority of the Series A Convertible
Preferred Stock on the matter described in the foregoing sentence. Any vacancy
in the office of a Series A Director shall be filled by a person designated
pursuant to the terms of Section 1(a) above and each of the Stockholders agrees
to vote, and shall vote, all of its shares of capital stock of the Company in
favor of such person.

            (b) Series B Director. The Series B Director may be removed during
his or her term of office, with or without cause, by and only by the affirmative
vote or written consent of Cerberus Partners, L.P. Each of the Stockholders
agrees to, and shall, vote all of its shares of capital stock in the same manner
as the vote cast or consent given by Cerberus Partners, L.P. on the matter
described in the foregoing sentence. Any vacancy in the office of the Series B
Director shall be filled by a person designated pursuant to Section 1(b) above
and each of the Stockholders agrees to, and shall, vote all of its shares of
capital stock of the Company in favor of such person.

            (c) Series C Director. The Series C Director may be removed during
his or her term of office, with or without cause, by and only by the affirmative
vote or written consent of Cerberus Partners, L.P.; provided, however, that if
Siemens has the right to appoint the Series C Director pursuant to Section 1(i)
then such Siemens Director may only be removed during his or her term of office,
with or without case, by and only by the affirmative vote or written consent of
Siemens. Each of the Stockholders agrees to, and shall, vote all of its shares
of capital stock in the same manner as the vote of or consent by Cerberus
Partners, L.P. or Siemens, as the case may be, on the matter described in the
foregoing sentence. Any vacancy in the office of the Series C Director shall be
filled by a person designated pursuant to Section 1(c) above and each of the
Stockholders agrees to, and shall, vote all of its shares of capital stock of
the Company in favor of such person.

            (d) Management Director. The Management Director may be removed
during his or her term of office, with or without cause, by the affirmative vote
of a majority of the members of the Board of Directors if such Management
Director no longer serves as the Company's President (or in a similar capacity
pursuant to Section 1(d) above) or by the affirmative vote or written consent
of the holders of a majority of the outstanding shares of the Series A Stock,
Series B Stock and Series C Stock voting together as a single class if such
Management Director no longer serves as Company's President (or in a similar
capacity pursuant to Section 1(d) above). Any vacancy in the office of the
Management Director shall be filled by a vote of the majority of the Board of
Directors consistent with the provisions of Section 1(d) above or by a vote of
the majority of the then-outstanding shares of capital stock of the Company, and
each of the Stockholders agrees to, and shall, vote all of its shares of capital
stock in favor of such person.

                                       -4-
<PAGE>

            (e) Industry Directors. Any Industry Director may be removed during
his or her term of office, with or without cause, by and only by the affirmative
vote of a majority of the members of the Board of Directors (which majority
shall include at least two of the Investor Directors) or by the affirmative vote
or written consent of the holders of a majority of the outstanding shares of the
Series A Stock, Series B Stock and Series C Stock voting together as a single
class. Any vacancy in an office of an Industry Director shall be filled by a
person designated by the President of the Company in consultation with the
senior management of the Company and approved by the Series B Director, such
approval not to be unreasonably withheld or delayed, and each of the
Stockholders agrees to, and shall, vote all of its shares of capital stock in
favor of such person.

      Section 3. Observer Rights. So long as all or any portion of the Series C
Preferred Stock is outstanding, the Co-Lead Investors shall have the right to
appoint one representative (a "Representative") to attend as an observer all
meetings of the Board of Directors (and each committee meeting thereof);
provided, that, in the case of telephonic meetings conducted in accordance with
the Company's by-laws and applicable law, the Representative shall be given the
opportunity to participate in such telephonic meetings to the same extent other
directors are permitted to participate. The Co-Lead Investors may replace their
Representative from time to time, and each such replacement shall be deemed a
"Representative" for purposes of this Section 3. The Co-Lead Investors shall be
required to furnish the name and address of its Representative (or any such
replacement) to the Company upon request therefore. The Company shall give each
Representative written notice of every meeting of its Board of Directors (and
any committee meeting thereof) at the same time and in the same manner as notice
is given to the directors of the Company. The Company shall bear, and reimburse
each Representative for, the reasonable costs of such Representative's
attendance at or participation in any meetings of the Board of Directors. Each
Representative shall be entitled to receive all written materials and other
information given to the directors of the Company in connection with all
meetings of the Board of Directors or otherwise at the same time and in the same
manner such materials and information are given to the directors. Prior to the
Company's obligations to provide notices and information hereunder, each
Representative shall execute and deliver to the Company a standard nondisclosure
agreement restricting the use or disclosure of any confidential information
received by such Representative pursuant to this Section 3. Each Representative
shall be entitled to consult with and advise the Board of Directors on business
issues with respect to the Company and its Subsidiaries, including management's
proposed annual operating plans for the Company and its Subsidiaries.
Notwithstanding the foregoing, the Company shall have the right to exclude any
Representative from attending any portion of a meeting and shall have the right
to withhold any written materials if the Board of Directors determines that such
exclusion or withholding is necessary due to a potential or actual conflict of
interest or determines that such exclusion or withholding is necessary to
protect the attorney-client privilege between the Company and such counsel. The
Company shall take all reasonably necessary steps to implement the provisions of
this Section 3.

                                       -5-
<PAGE>

      Section 4. Additional Parties and Definitions. If any of the Stockholders
transfer any of its shares of the Company's capital stock, such party shall
cause the execution by such persons or entities and the Company of a counterpart
of this Agreement and an amendment adding their names as signatories hereto as a
condition of any acquisition of such shares by such person or entity. This
Agreement shall thereafter be amended to include such additional persons or
entities without the necessity of procuring an amendment to this Agreement by
the other parties hereto. The Secretary of the Company shall promptly notify the
Stockholders of any purported transfer or disposition of shares by a stockholder
under this Agreement.

      Section 5. Severability; Governing Law. If any provisions of this
Agreement shall be determined to be illegal or unenforceable by any court of
law, the remaining provisions shall be severable and enforceable to the maximum
extent possible in accordance with their terms. This Agreement shall be governed
by, and construed in accordance with, the laws of the Commonwealth of
Massachusetts without giving effect to the principles of conflicts of law
thereof.

      Section 6. Injunctive Relief. It is acknowledged that it will be
impossible to measure the damages that would be suffered by any party if another
party fails to comply with the provisions of this Agreement and that in the
event of any such failure, the non-defaulting party will not have an adequate
remedy at law. The non-defaulting party shall, therefore, be entitled to obtain
specific performance of any defaulting party's obligations hereunder and to
obtain immediate injunctive relief. The defaulting party shall not argue, as a
defense to any proceeding for such specific performance or injunctive relief,
that the non-defaulting party has an adequate remedy at law.

      Section 7. Binding Effect. This Agreement shall be binding upon and inure
to the benefit of the parties hereto and their permitted successors and assigns,
legal representatives and heirs. This Agreement supercedes all prior agreements
(including without limitation the Prior Agreement, which is hereby rendered null
and void and of no further force and effect), whether written or oral, by and
between the Company and the Stockholders with respect to the subject matter set
forth herein.

      Section 8. Modification or Amendment. Neither this Agreement nor any
provision hereof can be modified, amended, changed, discharged or terminated
except by an instrument in writing, signed by (a) the Company (b) Cerberus
Partners, L.P. if it is then a Stockholder and (c) that number of Stockholders
representing at least 50% of the outstanding shares of the series of stock to be
affected by such amendment or change.

      Section 9. Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed to be an original, but all of which
taken together shall constitute one and the same instrument.

                                       -6-
<PAGE>

      Section 10. Notices. All notices to be given or otherwise made to any part
to this Agreement shall be deemed to be sufficient if contained in a written
instrument, delivered by hand in person, by express overnight courier service,
or by electronic facsimile transmission (with a confirming copy sent by U.S.
mail, first class, postage prepaid mail), or by first class mail, postage
prepaid, addressed, if to a Stockholder, at the last address of record in the
Company's stock record books and, if to the Company, at its principal offices.
All notices shall be considered to be delivered three (3) days after dispatch in
the event of first class or registered mail, and on the next succeeding business
day in the event of facsimile transmission (with confirmation of receipt) or
overnight courier service.

      Section 11. Duration of Agreement. The rights and obligations of the
Company and the Series C Holders under this Agreement shall terminate,
immediately prior to the consummation of and expressly conditioned upon a
Qualified Public Offering. The rights and obligations of the Company and the
Stockholders (other than the Series C Holders) under this Agreement shall
terminate, on the earlier to occur of the following: (a) immediately prior to
the consummation of and expressly conditioned upon a Qualified Public Offering,
(b) immediately prior to and expressly conditioned upon the consummation of the
sale of all, or substantially all, of the Company's assets or capital stock
either through a direct sale, merger, reorganization, consolidation or other
form of business combination or acquisition in which voting control of the
equity securities of the Company is transferred to a third party, or (c) ten
years from the date hereof.

                                       -7-
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Amended and
Restated Voting Agreement to be executed as of the date first above written.

                             MOLECULAR INSIGHT PHARMACEUTICALS, INC.

                             By: /s/ John W Babich
                                 ----------------------
                                 John Babich, President

                             COMMON STOCKHOLDERS:

                             /s/ David Barlow
                             ----------------
                             David Barlow

                             /s/ Phillip S. Magiera      04/24/05
                             ------------------------------------
                             Phillip S. Magiera

                             MEYTHALER INVESTORS:

                             By: /s/ L. Charles Meythaler
                                 ------------------------
                             Name: L. Charles Meythaler
                             Title: Manager

                             /s/ Ann Barlow
                             --------------
                             Ann Barlow

                             /s/ John W Babich
                             -----------------
                             John Babich

                             RAPHAEL, LLC

                             By: _________________
                             Name: Enrico Petrillo
                             Title:

                                      -8-
<PAGE>

                                   A PURCHASERS:

                                   /s/ David Barlow
                                   ----------------
                                   David Barlow

                                   /s/ James Poitras
                                   -----------------
                                   James Poitras

                                   /s/ Patricia T. Poitras
                                   -----------------------
                                   Patricia T. Poitras

                                   BOTH AS INDIVIDUALS AND
                                   AS TRUSTEES OF THEIR
                                   RESPECTIVE REVOCABLE TRUST

                                   ---------------------------
                                   James and Katherine Tambone

                                   /s/ Okjin Kim
                                   -------------
                                   Okjin Kim

                                   /s/ Ann Barlow
                                   --------------
                                   Ann Barlow

                                   MEYTHALER INVESTORS:

                                   By: /s/ L. Charles Meythaler
                                       ------------------------
                                   Name: L. Charles Meythaler
                                   Title: Manager

                                   B PURCHASERS:

                                   /s/ Frederick Frank
                                   -------------------
                                   Frederick Frank

                                   CERBERUS PARTNERS, L.P.:

                                   By: Cerberus Associates, L.L.C., its
                                       general partner

                                   By: /s/ Seth Plattus
                                       -------------------------------
                                       Seth Plattus, Managing Director

                                               -9-

<PAGE>

                                   By: /s/ Gerald Izzi MD
                                       -------------------------------
                                   Name: Other Series B Shareholder
                                   Title: GERALD IZZI

                                   C PURCHASERS:

                                   CERBERUS PARTNERS, L.P.:

                                   By: Cerberus Associates, L.L.C., its
                                       general partner

                                   By: /s/ Seth Plattus
                                       -------------------------------
                                       Seth Plattus, Managing Director

                                   SIEMENS VENTURE CAPITAL GMBH

                                   By: _______________________________
                                   Name:
                                   Title:

                                              -10-

<PAGE>

                            C PURCHASERS:

                            CERBERUS PARTNERS, L.P.:

                            By: Cerberus Associates, L.L.C., its general partner

                            By: /s/ Seth Plattus
                                -------------------------------
                                Seth Plattus, Managing Director

                            SIEMENS VENTURE CAPITAL GMBH

                            By: _______________________________
                            Name:
                            Title:

                                   M/M JAMES W. POITRAS
                                  3100 SPRINGHEAD COURT
                                 NARCOOSSEE FL 34771-8554

/s/ Patricia T. Poitras                                 /s/ James W. Poitras
-----------------------                                 --------------------
PATRICIA T. POITRAS                                     JAMES W. POITRAS

   BOTH AS INDIVIDUALS AND AS TRUSTEES OF THEIR RESPECTIVE REVOCABLE TRUSTS

                                      -11-
<PAGE>

                             C PURCHASER:

                             Andrew R Midler Family Trust

                             By: /s/ Andrew R. Midler
                                 ----------------------
                                 Name: Andrew R. Midler
                                 Title: Trustee

                                      -12-
<PAGE>

                             C PURCHASER:

                             John D. Singer, Esq.

                             By: /s/ John D. Singer, Esq.
                                 ---------------------------
                                 Name: John D. Singer, Esq.
                                 Title:

                                      -13-
<PAGE>

                             C PURCHASER:

                             MICHAEL C. DEUTSCH

                             By: /s/ Michael C. Deutsch
                                 --------------------------
                                 Name: Michael C. Deutsch
                                 Title:

                                      -14-
<PAGE>

                             C PURCHASER:

                             James W. Poitras

                             By: /s/ James W. Poitras
                                 -----------------------------------------------
                                 Name: JAMES W. POITRAS REVOCABLE TRUST V/A 29 N
                                 Title: JAMES W. POITRAS, TRUSTEE

                             By: /s/ Patricia T. Poitras
                                 -----------------------------------------------
                                 PATRICIA T. POITRAS REVOCABLE TRUST V/A 29 N
                                    PATRICIA T. POITRAS, TRUSTEE

                                      -15-
<PAGE>

                             C PURCHASER:
                             ________________________

                             By: /s/ Carol Frank
                                 --------------------
                                 Name:
                                 Title:

                                      -16-
<PAGE>

                             C PURCHASER:

                             Benjamin M. Frank Trust

                             By: /s/ Benjamin M. Frank
                                 ---------------------------
                                 Name:Benjamin M. Frank
                                 Title: Trustee

                                      -17-
<PAGE>

                             C PURCHASER:

                             John P. Davy
                             __________________________________

                             By:_______________________________
                                Name:
                                Title:

                                      -18-
<PAGE>

                             C PURCHASER:

                             RAJPAL SANDHU

                             /s/ Mary C. Henry
                             --------------------------------
                             Name: Rajpal Sandhu & Mary Henry
                             Title:

                                      -19-
<PAGE>

                            C PURCHASER:

                            JAMES T. LENEHAN

                            By: /s/ James T. Lenehan
                                ----------------------
                                Name: JAMES T. LENEHAN
                                Title:

                                      -20-
<PAGE>

                            C PURCHASER:

                            LIONEL N. STERLING REVOCABLE TRUST
                            -------------------------------------------

                            By: /s/ Lionel N. Sterling
                                ---------------------------------------
                                Name: LIONEL N. STERLING
                                Title: TRUSTEE

                                      -21-
<PAGE>

                            C PURCHASER:

                            America Durham, L.P.
                            -----------------------------
                            By: /s/ T. K. Duggan
                                -------------------------
                                Name: T. K. DUGGAN
                                Title: MANAGING PRINCIPAL

                                      -22-
<PAGE>

                            C PURCHASER:

                            International Durham, Ltd.

                            By: /s/ T. H. Dujga
                                ---------------------------------------
                                Name: T. H. Dujga
                                Title: [ILLEGIBLE]

                                      -23-
<PAGE>

                            C PURCHASER:

                            Institutional Benchmarks Master Fund-Canopus

                            By: /s/ Garry Crowder
                                ------------------------------------------
                                Name: GARRY CROWDER
                                Title: Director

                                      -24-
<PAGE>

                            C PURCHASER:

                            RICHARD SIMON

                            By: /s/ Richard Simon
                                -------------------
                                Name: RICHARD SIMON
                                Title:

                                      -25-
<PAGE>

                            C PURCHASER:

                            ___________________________________________

                            By: /s/ William R. Ebsworth
                                ---------------------------------------
                                Name: WILLIAM R. EBSWORTH
                                Title:

                                      -26-
<PAGE>

                            C PURCHASER:

                            Alan N. Berro

                            By: /s/ Alan N. Berro
                                ------------------
                                Name:
                                Title:

                                      -27-
<PAGE>

                            C PURCHASER:

                            Renee M. Noto

                            By: /s/ Renee M. Noto
                                -----------------
                                Name:
                                Title:

                                      -28-
<PAGE>

                            C PURCHASER:

                            THE RAPTOR GLOBAL PORTFOLIO LTD.

                            By: Tudor Investment Corporation

                            By: /s/ William T. Flaherty
                                -------------------------
                                Name: William T. Flaherty
                                Title: Managing Director

                                      -29-
<PAGE>

                            C PURCHASER:

                            THE TUDOR BVI GLOBAL PORTFOLIO LTD.

                            By: Tudor Investment Corporation

                            By: /s/ William T. Flaherty
                                -------------------------
                                Name: William T. Flaherty
                                Title: Managing Director

                                      -30-
<PAGE>

                            C PURCHASER:

                            TUDOR PROPRIETARY TRADING, L.L.C.

                            By: /s/ William T. Flaherty
                                -------------------------
                                Name: William T. Flaherty
                                Title: Managing Director

                                      -31-
<PAGE>

                            C PURCHASER:

                            William C. Smith

                            Dana Davis Smith

                            By: /s/ William C. Smith  /s/ Dana Davis Smith
                                --------------------------------------------
                                JOINT TENANTS WITH RIGHT OF SURVIVORSHIP

                                      -32-
<PAGE>

                            C PURCHASER:

                            THE ALTAR ROCK FUND L.P.
                            -------------------------------------------------
                            By: Tudor Investment Corporation, General Partner

                            By: /s/ William T. Flaherty
                                -------------------------
                                Name: William T. Flaherty
                                Title: Managing Director

                                      -33-
<PAGE>

                   C PURCHASER:

                   Julie R. Frank, Trustee

                   By: /s/ Julie R. Frank, Revocable Trust
                       --------------------------------------
                       Dated August 13, 2001
                       Name:
                       Title:

                                      -34-
<PAGE>

                            C PURCHASER:

                            ___________________________________________

                            By: /s/ John C. Otsuki
                                ---------------------------------------
                                Name: JOHN C. OTSUKI
                                Title:

                                      -35-
<PAGE>

                            C PURCHASER:

                            MedCap Partners L.P.

                            By: /s/ [ILLEGIBLE]
                                ---------------------------------------
                                Name: [ILLEGIBLE]
                                Title: Managing Member

                                      -36-
<PAGE>

                            C PURCHASER:

                            MedCap Master Fund, L.P.

                            By: /s/ [ILLEGIBLE]
                                ---------------------------------------
                                Name: [ILLEGIBLE]
                                Title: Managing Member of the GP

                                      -37-
<PAGE>

                            C PURCHASER:

                            Kenneth Rubin

                            By: /s/ Kenneth Rubin
                                ---------------------------------------
                                Name: Individually
                                Title:

                                      -38-
<PAGE>

                            C PURCHASER:

                            ___________________________________________

                            By: /s/ William P. Rice
                                ---------------------------------------
                                Name: WILLIAM P. RICE
                                Title:

                                      -39-
<PAGE>

                            C PURCHASER:

                            JAMES J. GOLL

                            By: /s/ James J. Goll
                                ---------------------------------------
                                Name: JAMES J. GOLL
                                Title:

                                      -40-
<PAGE>

                            C PURCHASER:

                            James M. Hirshberg

                            By: /s/ James M. Hirshberg
                                ---------------------------------------
                                Name:
                                Title:

                                      -41-
<PAGE>

                            C PURCHASER:

                            Dana Doe

                            By: /s/ Dana Doe
                                ---------------------------------------
                                Name:
                                Title:

                                      -42-
<PAGE>

                            C PURCHASER:

                            ___________________________________________

                            By: /s/ Daniel Frank
                                ---------------------------------------
                                Name: Daniel Frank
                                Title:

                                      -43-<PAGE>
                                                                    Exhibit 10.4

                            INVESTOR RIGHTS AGREEMENT

            THIS INVESTOR RIGHTS AGREEMENT (this "Agreement") is made as of this
29th day of March, 2005, by and among Molecular Insight Pharmaceuticals, Inc., a
Massachusetts corporation (the "Company"), and the investors identified on the
signature pages hereto (each an "Investor" and collectively the "Investors").

                                    RECITALS:

            A. Pursuant to the terms of a certain Stock Purchase Agreement, of
even date herewith, by and among the Company and the Investors (as amended,
restated, supplemented or otherwise modified from time to time, the "Purchase
Agreement"), the Company is issuing to the Investors an aggregate of 148,515
shares of a newly created series of the Company's preferred stock, par value
$0.01 per share, designated as "Series C Convertible Preferred Stock" (the
"Series C Preferred Stock"); and

            B. The parties hereto desire to enter into this Agreement to, among
other things, set forth the rights of the Investors with respect to: (i) the
registration of shares of Common Stock issuable to the Investors upon conversion
of the Series C Preferred Stock; (ii) the receipt of certain information from
the Company; and (iii) the participation in future issuances and transfers of
securities of the Company.

            NOW, THEREFORE, in consideration of the foregoing and the respective
covenants hereinafter set forth, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the Company and
each Investor, severally and not jointly, hereby agree as follows:

ARTICLE I DEFINITIONS.

      1.1 General Definitions. All capitalized terms not otherwise defined in
this Agreement shall have the meanings ascribed thereto in the Purchase
Agreement. As used in this Agreement, unless the context otherwise requires, the
following terms shall have the respective meanings set forth below:

            "Agreement" shall have the meaning ascribed to it in the preamble to
this Agreement.

            "Board" means the Board of Directors of the Company.

            "Cerberus" means Cerberus Capital Management, L.P., for itself
and/or one or more of its Affiliates and/or accounts managed by Cerberus Capital
Management, L.P., including, without limitation, Cerberus Partners, L.P.

            "Commission" means the U.S. Securities and Exchange Commission or
any other successor federal agency then administering the Securities Act of
1933, as amended, and other federal securities laws.

            "Common Stock" means the common stock, par value $.01 per share, of
the Company, and any other securities into which or for which such Common Stock
may be converted or exchanged pursuant to a plan of recapitalization,
reorganization, merger, consolidation, sale of assets or other similar
transaction.

            "Company" shall have the meaning ascribed to it in the preamble to
this Agreement.

<PAGE>

            "Exchange Act" means the Securities Exchange Act of 1934, as
amended, or any successor federal statute, and the rules and regulations of the
Commission issued under such Act, as they each may, from time to time, be in
effect.

            "Investor(s)" shall have the meaning ascribed to it in the preamble
to this Agreement.

            "Preferred Stock" means the Series A Preferred Stock, the Series B
Preferred Stock and the Series C Preferred Stock.

            "Purchase Agreement" shall have the meaning ascribed to it in the
recitals to this Agreement.

            "Qualified Public Offering" means a firm commitment underwritten
public offering of shares of the Common Stock in which the aggregate gross
proceeds thereof to the Company shall be no less than $30,000,000 and having a
per share offering price of at least $5.00.

            "Requisite Investors" means Cerberus and Investors holding at least
a majority of the Common Stock issuable upon conversion of the then issued and
outstanding shares of Series C Preferred Stock.

            "Series C Preferred Stock" shall have the meaning ascribed to it in
the recitals to this Agreement.

            "Shares" shall have the meaning ascribed to it in Section 3.1.

ARTICLE II INTENTIONALLY OMITTED.

ARTICLE III TRANSFER OBLIGATIONS.

      3.1 Transfers Prohibited. David Barlow, currently the Company's CEO
("Barlow"), shall not sell, assign, transfer, exchange, give, devise, pledge,
hypothecate, encumber or otherwise alienate or dispose of any shares of capital
stock of the Company (the "Shares") owned by him, or any right or interest
therein, whether voluntarily or involuntarily, by operation of law or otherwise,
except in accordance with this Agreement. Notwithstanding the foregoing or
Section 3.2 below, Barlow may transfer any or all of the Shares (i) to his
spouse or children or to a trust or partnership established for the benefit of
him, his spouse, his ex-spouse or his children, (ii) by will, or (iii) to his
Affiliates, provided that such Shares shall remain subject to this Agreement and
such permitted transferee shall, as a condition to such transfer, deliver to the
Company a written instrument confirming that such transferee shall be bound by
all of the terms and conditions of this Agreement. Except to the extent
otherwise required by applicable law, any transfer of title of any interest in
any of the Shares upon default, foreclosure, forfeit, or otherwise than by a
voluntary decision on the part of Barlow, other than any transfer upon death
(each, other than any transfer upon death, an "Involuntary Transfer"), shall be
void unless Barlow complies with this Article III and enables the Investors to
exercise in full their rights hereunder. Upon any Involuntary Transfer, the
Investors shall have the right to purchase such Shares pursuant to this Article
III and the Person to whom such Shares have been transferred (the "Involuntary
Transferee") shall have the obligation to sell such Shares in accordance with
this Article III. Upon the Involuntary Transfer of any Shares, Barlow shall
promptly (but in no event later than ten (10) days after such Involuntary
Transfer) furnish written notice to the Company and the Investors indicating
that the Involuntary Transfer has occurred, specifying the name of the
Involuntary Transferee, giving a description of the circumstances giving rise
to, and stating the legal basis for, the Involuntary Transfer. The Investors
shall have the right

                                       -2-

<PAGE>

to purchase, and the Involuntary Transferee shall have the obligation to
sell, all (but not less than all) of the Shares acquired by the Involuntary
Transferee for a purchase price per share equal to the fair market value per
Share as determined in good faith by the Board and otherwise in accordance with
the provisions of Section 3.2 below. The number of Shares which each Investor
shall have the right to purchase shall be determined in the same manner as set
forth below in Section 3.2 with respect to the exercise of the Investors' right
of first refusal.

      3.2. Rights of First Refusal on Voluntary Transfers.

            (a) Subject to Section 3.2(c), if Barlow intends to sell, assign,
transfer or otherwise voluntarily alienate or dispose of any Shares in one
transaction or a series of related transactions (the "Selling Stockholder"),
then the Selling Stockholder shall, prior to any such transfer, give written
notice (the "Selling Stockholder's Notice") of such intention to the Company and
the Investors. The Selling Stockholder's Notice shall include the name of the
proposed transferee, the proposed purchase price per Share, the terms of payment
of such purchase price and all other matters relating to such sale and shall be
accompanied by a copy of a binding written agreement of the proposed transferee
to purchase such Shares from the Selling Stockholder. If the Selling Stockholder
is to receive non-cash consideration from the proposed transferee named in the
Selling Stockholder's Notice, the Selling Stockholder's Notice shall specify the
"Fair Market Value" (as defined in the Articles of Amendment) of such non-cash
consideration as part of the purchase price to be paid for the Offered Shares by
the Investors. The Selling Stockholder's Notice shall constitute a binding offer
by the Selling Stockholder to sell to the Investors all or any part of such
number of such Shares (the "Offered Shares") then owned by the Selling
Stockholder as are proposed to be sold in the Selling Stockholder's Notice at
the monetary price per Share designated in the Selling Stockholder's Notice,
payable as provided in Section 3.2(b). Each Investor shall have the right to
purchase all or any part of its Series C Proportionate Percentage (as defined
below) of the Offered Shares at the monetary price per Share designated in the
Selling Stockholder's Notice, payable as provided in Section 3.2(b). Not later
than twenty (20) days after delivery of the Selling Stockholders' Notice, each
holder of Series C Preferred Stock shall deliver to the Company, the other
holders of Series C Preferred Stock and the Selling Stockholder a written notice
(the "Investor Notice") stating whether such holder of Series C Preferred Stock
has accepted the offer stated in the Selling Stockholder's Notice with respect
to its Series C Proportionate Percentage of the Shares. If one or more of such
holders of Series C Preferred Stock elects not to purchase all of the Shares
which it is entitled to purchase pursuant to this Section 3.2, the other such
holders of Series C Preferred Stock, by written notice to the Selling
Stockholder within seven (7) days after the end of the twenty (20) day period
set forth above, may elect to purchase all or a part of such unpurchased Shares
without the consent of any non-purchasing holders of Series C Preferred Stock,
pro rata between or among them or in such other manner as they may agree. The
closing of any purchase of the Offered Shares by the holders of Series C
Preferred Stock shall take place no later than fifteen (15) days after the end
of the twenty (20) day period set forth above. As used herein, "Series C
Proportionate Percentage" shall mean with respect to each holder of Series C
Preferred Stock a fraction, the numerator of which is the number of shares of
Series C Preferred Stock owned by such holder, and the denominator of which is
the total number of shares of Series C Preferred Stock owned by all holders of
Series C Preferred Stock. Each Investor shall be entitled to apportion shares
purchased under this Section 3.2(a) among its partners and Affiliates.

            (b) Closing. The place for the closing of any purchase and sale
described in Section 3.2(a) shall be the principal office of the Company or at
such other place as the parties shall agree in writing. At the closing, the
Selling Stockholder shall accept payment on the terms (including price) offered
by the proposed transferee named in the Selling Stockholder's Notice, provided,
however, that the Investors shall not be required to meet any non-monetary terms
of the proposed transfer, including, without limitation, delivery of
consideration in the form of other securities in exchange for the Shares
proposed to be sold, but shall be required to pay, in cash, the Fair Market
Value of such non-monetary

                                       -3-

<PAGE>

consideration. At the closing, the Selling Stockholder shall deliver
to the Investors in exchange for Shares purchased and sold at the closing,
certificates for the number of Shares stated in the Selling Stockholder's
Notice, accompanied by duly executed instruments of transfer.

            (c) Transfers to Third Parties. If the Investors fail to accept the
offer stated in the Selling Stockholder's Notice with respect to all of the
Offered Shares, they shall not have the right to purchase any Offered Shares,
and the Selling Stockholder shall be free, subject to compliance with Section
3.3, to sell all, but not less than all, of the Offered Shares to the designated
transferee at a price and on terms no less favorable to the Selling Stockholder
than described in the Selling Stockholder's Notice, provided, however, that such
sale is consummated within ninety (90) days after the giving of the Selling
Stockholder's Notice pursuant to Section 3.2(a). As a condition precedent to the
effectiveness of a transfer pursuant to this Section 3.2(c), the proposed
transferee(s) shall agree in writing prior to such transfer to become a party to
this Agreement and shall thereafter be permitted to transfer Shares only in
accordance with this Agreement; provided, however, that if such proposed
transferee(s) is a bona fide third party, the transfer of Shares by such
transferee shall not thereafter be subject to this Section 3.2.

      3.3 Participation in Sales.

            (a) Co-Sale Right. To the extent that the Investors do not exercise
their respective rights of refusal as to all of the Offered Shares pursuant to
Section 3.2, then each Investor shall have the right to participate in such sale
of securities, at the same price per Share and on the same terms and conditions
as stated in the Selling Stockholder Notice (including any non-cash
consideration), up to the number of Shares equal to the aggregate number of
Offered Shares multiplied by a fraction, the numerator of which is the aggregate
number of Shares held by such Investor (calculated on an as converted basis) and
the denominator of which is the aggregate number of Shares held by the Selling
Stockholder and all participating Investors (calculated on an as converted
basis). To the extent one or more of the Investors exercise such right of
participation in accordance with the terms and conditions of this Section 3.3,
the number of Shares that the Selling Stockholder may sell in the transfer shall
be correspondingly reduced.

            (b) Notices of Offer and Intent to Participate. If an Investor
wishes to participate in any sale pursuant to Section 3.3(a), it shall notify
the Selling Stockholder in writing of such intention and the number of Shares it
wishes to sell pursuant to this Section 3.3 not later than the end of the 20-day
period described in Section 3.2(a) above. If the Selling Stockholder does not
receive such notice from an Investor within such 20-day period, the Selling
Stockholder shall be free to consummate the proposed transaction without any
obligation to include such Investor's Shares in such transaction.

            (c) Closing. Each participating Investor shall effect its
participation in a sale contemplated by Section 3.3(a) by promptly delivering to
the Selling Stockholder for transfer to the prospective purchaser one or more
certificates, properly endorsed for transfer, which represent the type and
number of Shares which such Investor elects to sell, or that number of shares of
Series C Preferred Stock which are at such time convertible into the number of
shares of Common Stock which such Investor elects to sell. The stock certificate
or certificates that the Investor delivers to the Selling Stockholder pursuant
to this Section 3.3(c) shall be transferred to the prospective purchaser in
consummation of the sale of the securities pursuant to the terms and conditions
specified in the Selling Stockholder Notice, and the Selling Stockholder shall
concurrently therewith remit to such participating Investor that portion of the
sale proceeds to which such participating Investor is entitled by reason of its
participation in such sale. To the extent that any prospective purchaser or
purchasers prohibits such assignment or otherwise refuses to purchase shares or
other securities from an Investor exercising its rights of co-sale hereunder,
the Selling Stockholder shall not sell to such prospective purchaser or
purchasers any securities unless and until, simultaneously with such sale, the
Selling Stockholder shall

                                       -4-

<PAGE>

purchase such Shares or other securities from such participating Investor for
the same consideration and on the same terms and conditions as the proposed
transfer described in the Selling Stockholder Notice.

      3.4 Legend; Termination.

            (a) Each certificate representing the shares of capital stock now or
hereafter held of record or beneficially owned by Barlow shall bear a legend in
substantially the following form, until such time as the shares of capital stock
represented thereby are no longer subject to the provisions hereof:

            THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO THE
            TERMS AND CONDITIONS OF AN INVESTOR RIGHTS AGREEMENT AMONG THE
            COMPANY AND CERTAIN OF ITS STOCKHOLDERS DATED AS OF MARCH ___, 2005,
            AS THE SAME MAY BE AMENDED OR AMENDED AND RESTATED FROM TIME TO
            TIME, WHICH, AMONG OTHER THINGS, RESTRICTS THE TRANSFER OF SUCH
            SECURITIES. A COPY OF SUCH AGREEMENT IS AVAILABLE FOR INSPECTION AT
            THE OFFICES OF THE COMPANY OR MAY BE OBTAINED AT NO COST BY WRITTEN
            REQUEST TO THE SECRETARY OF THE COMPANY.

Upon execution of this Agreement, certificates for any shares of capital stock
of the Company now or hereafter held of record or beneficially owned by Barlow
shall be surrendered to the Company for endorsement with the above legend and
then returned to Barlow, and hereafter the Company shall cause the above legend
to be placed on all certificates issued by it to or for the benefit of Barlow
which represent any additional shares of capital stock of the Company.

            (b) The respective rights and obligations of the parties under this
Article III shall terminate upon the earlier to occur of (i) the consummation of
a Qualified Public Offering and (ii) the consummation of a Liquidation Event. At
any time after termination of the rights and obligations under this Article III,
the Company shall, upon Barlow's request, promptly re-issue certificate(s)
without the legend required by Section 3.4(a) representing the securities held
of record beneficially owned by Barlow evidenced by such certificate(s) as are
surrendered to the Company by Barlow for such re-issuance.

ARTICLE IV FINANCIAL STATEMENTS; INFORMATION AND INSPECTION RIGHTS.

      4.1. Delivery of Financial Statements. The Company shall deliver to each
holder of shares of Series C Preferred Stock, as soon as available after the end
of each fiscal year of the Company, the audited financial statements of the
Company for such fiscal year then ended, together with the written opinion of
the auditor rendered in connection therewith. With respect to such financial
statements, if for any fiscal year, the Company shall have any Subsidiary whose
accounts are consolidated with those of the Company, then in respect of such
period, the financial statements delivered pursuant to the foregoing section
shall be the consolidated and consolidating financial statements of the Company
and all such consolidated subsidiaries.

      4.2. Information Rights. The Company shall furnish to each holder of at
least 9,901 shares of Series C Preferred Stock within five (5) business days
after an executive officer of the Company or its Subsidiaries, as the case may
be, has knowledge of the occurrence of a default hereunder, or under any
material agreement of the Company or its Subsidiaries, including without
limitation any loan or financing agreement, the commencement of any lawsuit,
action, administrative or arbitration or other proceeding against or
investigation with respect to the Company or the occurrence of any event,
dispute or other development which is reasonably likely (with or without the
passage of time) to have a Material Adverse

                                       -5-

<PAGE>

Effect, or any effect, condition, event, or circumstance that has resulted in a
Material Adverse Effect, a statement from the President of the Company
describing such occurrence and management's anticipated response. The Company
shall furnish to each such holder such other financial and other reports or
information of the Company and its Subsidiaries as any of such holders may
reasonably request with respect to the foregoing or otherwise with respect to
the operations of the Company.

      4.3. Inspection Rights. The Company shall permit each holder of at least
9,901 shares of Series C Preferred Stock, at the Company's expense, to visit and
inspect the Company's properties, to examine its books of account and records
and to discuss the Company's affairs, finances and accounts with its officers
for purposes of allowing such Investor to monitor its investment in the Company,
all at such reasonable times and upon reasonable notice as may be reasonably
requested by such Investor.

      4.4. Limitations. Notwithstanding anything contained herein to the
contrary, the financial reporting requirements and information and inspection
rights contained in this Article IV (i) shall apply only for so long as the
Company is not filing periodic reports with the Commission pursuant to Section
13 or Section 15 of the Exchange Act and (ii) shall be subject to the execution
of confidentiality and non-compete agreements by the Persons requesting such
information, in form and substance reasonably satisfactory to the Company.

ARTICLE V MISCELLANEOUS.

      5.1. Successors and Assigns. This Agreement may not be assigned by a party
hereto without the prior written consent of the Company or Cerberus, as
applicable; provided, however, that an Investor may assign its rights and
delegate its duties hereunder in whole or in part, without the prior written
consent of the Company, to an Affiliate and to any Person to whom such Investor
transfers any shares of the Series C Preferred Stock, provided, that, no such
assignment shall be effective or confer any right on any such assignee unless,
prior to such assignment, the assignee agrees in writing that such assignee will
be bound by all provisions binding on such Investor. The provisions of this
Agreement shall inure to the benefit of and be binding upon the respective
permitted successors and assigns of the parties. Except for any other provisions
of this Agreement expressly to the contrary, nothing in this Agreement, express
or implied, is intended to confer upon any party other than the parties hereto
or their respective successors and assigns any rights, remedies, obligations, or
liabilities under or by reason of this Agreement.

      5.2. Counterparts; Faxes. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. This Agreement may also
be executed via facsimile, which shall be deemed an original.

      5.3. Titles and Subtitles. The titles and subtitles used in this Agreement
are used for convenience only and are not to be considered in construing or
interpreting this Agreement.

      5.4. Notices. Unless otherwise provided, any notice required or permitted
under this Agreement shall be given in writing and shall be deemed effectively
given as hereinafter described: (i) if given by personal delivery, then such
notice shall be deemed given upon such delivery; (ii) if given by telex or
telecopier, then such notice shall be deemed given upon receipt of confirmation
of complete transmittal with a confirming copy by first class mail; (iii) if
given by mail, then such notice shall be deemed given upon the earlier of (A)
receipt of such notice by the recipient or (B) three (3) days after such notice
is deposited in first class mail, postage prepaid; and (iv) if given by an
internationally recognized overnight air courier, then such notice shall be
deemed given one (1) Business Day after delivery to such carrier. All notices
shall be addressed to the party to be notified at the address as follows, or at
such other address as such party may designate by ten (10) days' advance written
notice to the other party:

                                       -6-

<PAGE>

                              If to the Company:

                              Molecular Insight Pharmaceuticals, Inc.
                              160 Second Street
                              Cambridge, Massachusetts 02142
                              Attn: David Barlow
                              Fax: (617)492-5664

                              With a copy to:

                              Foley & Lardner LLP
                              111 Huntington Avenue
                              26th Floor
                              Boston, Massachusetts 02199
                              Attn: Gabor Garai,Esq.
                              Fax: (617)342-4001

                              If to any of the Investors:

                              to the addresses set forth on the signature
                              pages attached hereto.

or to such other address as any party hereto shall notify the other
parties hereto (as provided above) from time to time.

      5.5. Expenses. The Company agrees to pay all reasonable out-of-pocket
expenses relating to the establishment, due diligence and monitoring of and the
administration and exercise of any rights in, and enforcement of, the
transactions contemplated by this Agreement and the other Transactions
Documents, which arise after the date hereof, and such expenses may include, but
not be limited to legal, travel, accounting and Board attendance expenses. Such
expenses shall be paid by the Company to the Investors as incurred and upon the
request of each such Investor. In the event that legal proceedings are commenced
by any party to this Agreement against another party to this Agreement in
connection with this Agreement or the other Transaction Documents, the party or
parties which do not prevail in such proceedings shall severally, but not
jointly, pay their pro rata share of the reasonable attorneys' fees and other
reasonable out-of-pocket costs and expenses incurred by the prevailing party in
such proceedings.

      5.6 Amendments and Waivers. This Agreement shall not be amended without
the prior written consent of the Requisite Investors. The Company may take any
action herein prohibited, or omit to perform any act herein required to be
performed by it, only if the Company shall have obtained the written consent to
such amendment, action or omission to act, of the Requisite Investors.

      5.7. Publicity. No public release or announcement concerning the
transactions contemplated by this Agreement or any other Transaction Document
shall be issued by the Company or the Investors without the prior consent of the
Company (in the case of a release or announcement by any of the Investors) or
Cerberus (in the case of a release or announcement by the Company) (which
consents shall not be unreasonably withheld), except as such release or
announcement may be required by law, in which case the Company or the Investors,
as the case may be, shall allow the Investors or the Company, as applicable, to
the extent reasonably practicable in the circumstances, reasonable time to
comment on such release or announcement in advance of such issuance.

      5.8. Severability. Any provision of this Agreement that is prohibited or
unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective
to the extent of such prohibition or

                                       -7-

<PAGE>

unenforceability without invalidating the remaining provisions hereof but shall
be interpreted as if it were written so as to be enforceable to the maximum
extent permitted by applicable law, and any such prohibition or unenforceability
in any jurisdiction shall not invalidate or render unenforceable such provision
in any other jurisdiction. To the extent permitted by applicable law, the
parties hereby waive any provision of law which renders any provision hereof
prohibited or unenforceable in any respect.

      5.9. Entire Agreement. This Agreement, including the Exhibits and
Schedules, and the other Transaction Documents constitute the entire agreement
among the parties hereof with respect to the subject matter hereof and thereof
and supersede all prior agreements and understandings, both oral and written,
between the parties with respect to the subject matter hereof and thereof.

      5.10. Further Assurances. The parties shall execute and deliver all such
further instruments and documents and take all such other actions as may
reasonably be required to carry out the transactions contemplated hereby and to
evidence the fulfillment of the agreements herein contained.

      5.11. Governing Law; Consent to Jurisdiction. This Agreement shall be
governed by, and construed in accordance with, the internal laws of the State of
New York without regard to the choice of law principles thereof. Each of the
parties hereto irrevocably submits to the jurisdiction of the courts of the
State of New York located in New York County and the United States District
Court for the Southern District of New York for the purpose of any suit, action,
proceeding or judgment relating to or arising out of this Agreement and the
transactions contemplated hereby. Service of process in connection with any such
suit, action or proceeding may be served on each party hereto anywhere in the
world by the same methods as are specified for the giving of notices under this
Agreement. Each of the parties hereto irrevocably consents to the jurisdiction
of any such court in any such suit, action or proceeding and to the laying of
venue in such court. Each party hereto irrevocably waives any objection to the
laying of venue of any such suit, action or proceeding brought in such courts
and irrevocably waives any claim that any such suit, action or proceeding
brought in any such court has been brought in an inconvenient forum.
THE COMPANY AND EACH OF THE INVESTORS HEREBY IRREVOCABLY WAIVES ANY AND ALL
RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING RELATING TO OR ARISING OUT OF
THIS AGREEMENT OR ANY OTHER TRANSACTION DOCUMENT AND THE TRANSACTIONS
CONTEMPLATED HEREBY AND THEREBY.

      5.12 Independent Nature of Investors' Obligations and Rights. Except as
expressly provided herein and therein, the obligations of each Investor under
this Agreement and each other Transaction Document are several and not joint
with the obligations of any other Investor (regardless of the Closing at which
such Investor purchased its Series C Preferred Stock), and no Investor shall be
responsible in any way for the performance of the obligations of any other
Investor (regardless of the Closing at which such Investor purchased its Series
C Preferred Stock) under this Agreement or any other Transaction Document. The
decision of each Investor to purchase Series C Preferred Stock pursuant to this
Agreement and the other Transaction Documents has been made by such Investor
independently of any other Investor (regardless of the Closing at which such
Investor purchased its Series C Preferred Stock). Nothing contained herein or in
any other Transaction Document, and no action taken by any Investor (including,
without limitation, any of the Co-lead Investors) pursuant hereto or thereto,
shall be deemed to constitute the Investors (regardless of the Closing at which
such Investor purchased its Series C Preferred Stock) as a partnership, an
association, a joint venture or any other kind of entity, or create a
presumption that the Investors are in any way acting in concert or as a group
with respect to such obligations or the transactions contemplated by this
Agreement or the other Transaction Documents. Each Investor acknowledges that no
other Investor (including, without limitation, any of the Co-lead Investors, and
regardless of the Closing at which such Investor purchased its Series C
Preferred Stock) has acted as agent for such Investor in connection with making
its investment hereunder and that no Investor (including, without limitation,
any of the Co-lead Investors, and regardless of the Closing at which such

                                       -8-

<PAGE>

Investor purchased its Series C Preferred Stock) will be acting as agent of such
Investor in connection with monitoring its investment in the Shares or enforcing
its rights under this Agreement or the other Transaction Documents. Each
Investor shall be entitled to independently protect and enforce its rights,
including, without limitation, the rights arising out of this Agreement or out
of the other Transaction Documents, and it shall not be necessary for any other
Investor (regardless of the Closing at which such Investor purchased its Series
C Preferred Stock) to be joined as an additional party in any proceeding for
such purpose. The Company acknowledges that each of the Investors has been
provided with the same Transaction Documents for the purpose of closing a
transaction with multiple Investors at multiple Closings and not because it was
required or requested to do so by any Investor. Notwithstanding anything
contained in this Agreement or any other Transaction Document to the contrary,
neither of the Co-Lead Investors shall have any duty, fiduciary or otherwise, to
any other Investor (regardless of the Closing at which such Investor purchased
its Series C Preferred Stock) by virtue of such Investor serving as a Co-Lead
Investor or otherwise.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -9-

<PAGE>

                            [COMPANY SIGNATURE PAGE]

      IN WITNESS WHEREOF, the parties hereto have executed this Agreement or
caused this Agreement to be executed by their duly authorized representatives,
as of the date first written above.

                                     THE COMPANY:

                                     MOLECULAR INSIGHT PHARMACEUTICALS, INC.

                                     By: /s/ David S. Barlow
                                         -------------------
                                     Name: David S. Barlow
                                     Title: Chairman & CEO

                                     /s/ David S. Barlow
                                     -----------------------
                                     DAVID BARLOW, SOLELY FOR PURPOSES OF
                                     ARTICLES IV AND VI OF THE AGREEMENT

                                      -10-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        CERBERUS PARTNERS, L.P.

                                        By: Cerberus Associates, LLC,
                                            its General Partner

                                        By: /s/ Seth Plattus
                                            -----------------
                                            Seth Plattus
                                            Managing Director

                                        Address: 299 Park Avenue
                                                 22nd Floor
                                                 New York, NY 10171

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        Lowenstein Sandler PC
                                        65 Livingston Avenue
                                        Roseland, NJ 07068
                                        Attn: Robert G. Minion, Esq.
                                        Fax: (973) 597-2400

                                      -11-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Andrew R Midler Family Trust 5/99
                                        ---------------------------------

                                        By: /s/ Andrew R Midler
                                            ---------------------
                                            Name: Andrew R Midler
                                            Title: Trustee

                                        Address: 283 Summit Ave
                                                 ---------------------
                                                 Mill Valley Ca 94941
                                                 ---------------------

                                                 ---------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        -------------------------

                                        -------------------------

                                        -------------------------

                                      -12-
<PAGE>
                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        John D. Singer, Esq.
                                        ----------------------------------

                                        By: /s/ John D. Singer, Esq.
                                            -------------------------
                                            Name: John D. Singer, Esq.
                                            Title:

                                        Address: 200 East 69th Street
                                                 -------------------------
                                                 Apartment #18-E
                                                 -------------------------
                                                 New York, NY 10021
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        -------------------------

                                        -------------------------

                                        -------------------------

                                      -13-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        MICHAEL C. DEUTSCH
                                        ----------------------------------

                                        By: /s/ Michael C. Deutsch
                                            ----------------------
                                            Name: Michael C. Deutsch
                                            Title:

                                        Address: 331 Madison Ave, 3rd Floor
                                                 -------------------------
                                                 New York, NY 10017
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -14-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                       NAME OF INVESTOR:

                                       -----------------------------------

  /s/ Patricia T. Poitras              By: /s/ James W Poitras
  -----------------------                  -------------------
  Patricia T. Poitras Revocable Trust      Name: James W Poitras Revocable Trust
  V/A 29 Nov 04                                  V/A 29 Nov.
                                           Title: James W Poitras Trustee
  Patricia T. Poitras Trustee

                                       Address: M/M JAMES W. POITRAS
                                                --------------------------
                                                3100 SPRINGHEAD COURT
                                                --------------------------
                                                NARCOOSSEE FL 34771-8554
                                                --------------------------

                                       With a copy to (which shall not be
                                       deemed notice for purposes of the
                                       Agreement):

                                       JW POITRAS@ALUM.MIT.EDU
                                       -----------------------------------

                                       -----------------------------------

                                       -----------------------------------

                                      -15-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Carol Frank
                                        -------------------------

                                        By:
                                            ---------------------
                                            Name:
                                            Title:

                                        Address: 11529 Conway Rd
                                                 -------------------------
                                                 St. Louis MO 63131
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        -------------------------

                                        -------------------------

                                        -------------------------

                                      -16-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Benjamin M. Frank Trust
                                        ----------------------------------

                                        By: /s/ Benjamin M. Frank
                                            ---------------------
                                            Name: Benjamin M. Frank
                                            Title: Trustee

                                        Address: 106 Breckenwood Way
                                                 -------------------------
                                                 Sacramento CA 95864
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                         -17-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        /s/ John P. Davy
                                        ----------------------------------

                                        By: John P. Davy
                                           -------------------------
                                           Name:
                                           Title:

                                        Address: 16413 NE 135th St
                                                 -------------------------
                                                 Redmond, WA 98052
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        KRIS DAVY
                                        ----------------------------------
                                        16413 NE 135 St
                                        ----------------------------------
                                        Redmond WA 98052
                                        ----------------------------------

                                      -18-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Rajpal Sandhu
                                        ----------------------------------

                                        By: /s/ Mary C Henry
                                            ----------------
                                            Name: Rajpal Sandhu & Mary Henry
                                            Title:

                                        Address: 420 FAMILY FARM ROAD
                                                 -------------------------
                                                 WOODSIDE, CA-94062
                                                 -------------------------
                                                 650-529-0606
                                                 -------------------------
                                                 Raj@RajSandhu.com

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -19-
<PAGE>

                           [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        ----------------------------------

                                        By: /s/ James T. Lenehan
                                            --------------------
                                            Name: James T. Lenehan
                                            Title:

                                        Address: 1586 HAMPTON RD
                                                 -------------------------
                                                 RYDAL, PA
                                                 -------------------------
                                                 19046
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -20-

<PAGE>

                            [INVESTOR SIGNATURE PAGE)

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Lionel N. Sterling Revocable Trust
                                        ----------------------------------

                                        By: /s/ Lionel N. Sterling
                                            ----------------------
                                            Name: Lionel N. Sterling
                                            Title: Trustee

                                        Address: 631 WEST RD.
                                                 -------------------------
                                                 NEW CANAAN CT.
                                                 -------------------------
                                                 06840
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        LIONEL N. STERLING
                                        ----------------------------------
                                        c/o EQUITY RESOURCES INC. 4th FL.
                                        ----------------------------------
                                        5 GREENWICH OFFICE PARK
                                        ----------------------------------
                                        GREENWICH CT. 06831
                                        ----------------------------------

                                      -21-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        American Durham, L.P.
                                        ----------------------------------

                                        By: /s/ T.K. Duggan
                                            --------------------
                                            Name: T.K. DUGGAN
                                            Title: Managing Principal

                                        Address: 680 5th Ave.
                                                 -------------------------
                                                 22nd Floor
                                                 -------------------------
                                                 N.Y, N.Y 10019
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -22-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        International Durham, Ltd.
                                        ----------------------------------

                                        By: /s/ T.K. Duggan
                                            --------------------
                                            Name:  T.K. Duggan
                                            Title: Managing Principal

                                        Address: 680 5th Ave.
                                                 -------------------------
                                                 22nd Floor
                                                 -------------------------
                                                 N.Y, N.Y 10019
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -23-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        International Benchmarks Master Fund
                                        ------------------------------------

                                        By: /s/ Garry Crowder
                                            ----------------------
                                            Name: Garry Crowder
                                            Title: Director

                                        Address:
                                                 -------------------------

                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -24-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Richard Simon
                                        ----------------------------------
                                        By: /s/ Richard Simon
                                            -----------------
                                            Name:
                                            Title:

                                        Address: 219 LAKE AVENUE
                                                 -------------------------
                                                 NEWTON, MA 02461
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -25-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        ---------------------------

                                        By: /s/ William R. Ebsworth
                                            -----------------------
                                            Name: William R. Ebsworth
                                            Title:

                                        Address: 17 AUDUBON RD
                                                 -------------------------
                                                 WESTON MA 02493
                                                 -------------------------

                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -26-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Alan N. Berro
                                        ----------------------------------

                                        By: /s/ Alan N. Berro
                                            -----------------
                                            Name:
                                            Title:

                                        Address: P.O. BOX 15155
                                                 -------------------------
                                                 BEVERLY HILLS CA
                                                 -------------------------
                                                 90209
                                                 -------------------------

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ----------------------------------

                                        ----------------------------------

                                        ----------------------------------

                                      -27-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Renee M. Noto

                                        By: /s/ Renee M. Noto
                                            -----------------
                                            Name:
                                            Title:

                                        Address: 275 Stanwich Road
                                                 Greenwich, CT 06530

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        _____________________
                                        _____________________
                                        _____________________

                                      -28-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        THE RAPTOR GLOBAL PORTFOLIO LTD.

                                        By: Tudor Investment Corporation,
                                            Investment Advisor

                                        By: /s/ William T. Flaherty
                                            -----------------------
                                            Name: William T. Flaherty
                                            Title: Managing Director

                                        Address: c/o Tudor Investment
                                                 Corporation
                                                 50 Rowes Wharf, 6th Floor
                                                 Boston, MA 02110

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ___________________________
                                        ___________________________
                                        ___________________________

                                      -29-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        THE TUDOR BVI GLOBAL PORTFOLIO LTD.

                                        By: Tudor Investment Corporation,
                                            Trading Advisor

                                        By: /s/ William T. Flaherty
                                            -----------------------
                                            Name: William T. Flaherty
                                            Title: Managing Director

                                        Address: c/o Tudor Investment
                                                 Corporation
                                                 50 Rowes Wharf, 6th Floor
                                                 Boston, MA 02110

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ___________________________
                                        ___________________________
                                        ___________________________

                                      -30-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        TUDOR PROPRIETARY TRADING, L.L.C.

                                        By: /s/ William T. Flaherty
                                            -----------------------
                                            Name: William T. Flaherty
                                            Title: Managing Director

                                        Address: 50 Rowes Wharf, 6th Floor
                                                 Boston, MA 02110

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        __________________________
                                        __________________________
                                        __________________________

                                      -31-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        By: /s/ William C. Smith
                                            --------------------
                                            William C. Smith

                                            /s/ Dana Davis Smith
                                            --------------------
                                            Dana Davis Smith

                                        JOINT TENANTS WITH RIGHT
                                        OF SURVIVORSHIP

                                        Address: 218 RIVER PARK DRIVE
                                                 GREAT FALLS, VA 22066

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ________________________
                                        ________________________
                                        ___________________

                                      -32-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        THE ALTAR ROCK FUND L.P.

                                        By: Tudor Investment Corporation,
                                            General Partner

                                        By: /s/ William T. Flaherty
                                            -----------------------
                                            Name: William T. Flaherty
                                            Title: Managing Director

                                        Address: c/o Tudor Investment
                                                 Corporation
                                                 50 Rowes Wharf, 6th Floor
                                                 Boston, MA 02110

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        __________________________
                                        __________________________
                                        __________________________

                                      -33-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Julie R. Frank, Trustee

                                        By: /s/ Julie R. Frank Revocable Trust
                                            ----------------------------------
                                            Dated August 13, 2001
                                            Name:
                                            Title:

                                        Address: 3 Roclare Lane
                                                 St. Louis, MO 63131

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        _____________________________________
                                        _____________________________________
                                        _____________________________________

                                      -34-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        ______________________

                                        By: /s/ John C. Otsuki
                                            ------------------
                                            Name: John C. Otsuki
                                            Title:

                                        Address: 4718 MERIVALE RD.
                                                 CHEVY CHASE, MD 20815

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ______________________
                                        ______________________
                                        ______________________

                                      -35-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        MedCap Partners L.P.

                                        By: /s/ [ILLEGIBLE]
                                            ---------------
                                            Name: [ILLEGIBLE]
                                            Title: Managing Member

                                        Address: 500 Third Street, Suite 535
                                                 San Francisco, CA 94107

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        __________________
                                        __________________
                                        __________________

                                      -36-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        MedCap Master Fund, L.P.

                                        By: /s/ [ILLEGIBLE]
                                            ---------------
                                            Name: [ILLEGIBLE]
                                            Title: Managing Member of the GP

                                        Address: ATC Trustees (Cayman) Limited
                                                 [ILLEGIBLE]), 2nd Floor,
                                                 Harbour Drive
                                                 George Town, Grand Cayman
                                                 Cayman Islands

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        500 Third Street # 535
                                        San Francisco, CA 94107

                                      -37-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        Keneth Rubin

                                        By: /s/ Kenneth Rubin
                                            ----------------
                                            Name: Kenneth Rubin
                                            Title: Individually

                                        Address: 68 Barkers Point Road
                                                 Sands Point, NY 11050

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ____________________
                                        ____________________
                                        ____________________

                                      -38-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        WILLIAM P. RICE

                                        By: /s/ William P. Rice
                                            -------------------
                                            Name: WILLIAM P. RICE
                                            Title:

                                        Address: P.O. BOX 1599
                                                 DUXBURY, MA 02331

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ______________________
                                        ______________________
                                        ______________________

                                      -39-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        James J. Goll

                                        By: /s/ James J. Goll
                                            -----------------
                                            Name: James J. Goll
                                            Title:

                                        Address: 32 Three Wells Lane
                                                 Darien, CT 06820
                                                 (203) 656-0228
                                                 JJCG@SBCGLOBAL.NET

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        _____________________
                                        _____________________
                                        _____________________

                                      -40-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        __________________________

                                        By: /s/ James M. Hirshberg
                                            ----------------------
                                            Name: James M. Hirshberg
                                            Title:

                                        Address: 62 PRINCE ST
                                                 WEST NEWTON, MA 02465

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        __________________________
                                        __________________________
                                        __________________________

                                      -41-
<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        ___________________

                                        By: /s/ Dana G. Doe
                                            ---------------
                                            Name: Dana G. Doe
                                            Title:

                                        Address: [ILLEGIBLE]

                                        Winchester, MA 01890

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ___________________
                                        ___________________
                                        ___________________

                                      -42-

<PAGE>

                            [INVESTOR SIGNATURE PAGE]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the
date first above written.

                                        NAME OF INVESTOR:

                                        ____________________

                                        By: /s/ Daniel Frank
                                            ----------------
                                            Name: Daniel Frank
                                            Title:

                                        Address: 19 WHALING ROAD
                                                 DARIEN CT 06820

                                        With a copy to (which shall not be
                                        deemed notice for purposes of the
                                        Agreement):

                                        ____________________
                                        ____________________
                                        ____________________

                                      -43-

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