Document:

Warrant

 Exhibit 4.2 

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”),
OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER APPLICABLE FEDERAL AND STATE SECURITIES LAWS OR PURSUANT TO AN APPLICABLE EXEMPTION FROM, OR IN A TRANSACTION NOT
SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, WHICH OPINION SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

 Issuance Date: June 24, 2014 

HEDGEPATH PHARMACEUTICALS, INC. 

Common Stock Purchase Warrant 

THIS CERTIFIES THAT, for value received, Hedgepath, LLC, a Florida limited liability company (the
“Holder”), is entitled to subscribe for and purchase, at the Exercise Price (as defined below), from HedgePath Pharmaceuticals, Inc., a Delaware corporation (the “Company”), shares of the Company’s common
stock, par value $0.0001 (the “Common Stock”), at any time prior to the five (5) year anniversary of the issuance date of this Warrant as set forth above (the “Warrant Exercise Term”). 

The Company issues this Warrant in connection with, among other things, that certain Debt Forgiveness Agreement by and between the Company and
the Holder, dated on or about a date even herewith (the “Agreement”). 
 This Warrant is subject to the following terms and
conditions: 
 1. Shares. The Holder has, subject to the terms set forth herein, the right to purchase up to an aggregate of Ten
Million Two Hundred Fifty Thousand Five Hundred Sixty-Nine (10,250,569) shares (subject to adjustment as provided herein, “Shares” and each a “Share”) of Common Stock at a per share exercise price of $0.0878
(subject to adjustment as provided herein, the “Exercise Price”). 
 2. Exercise of Warrant. 

(a) Exercise. This Warrant may be exercised by the Holder at any time prior to the expiration of the Warrant Exercise Term, in whole or
in part, by delivering the notice of exercise attached as Exhibit A hereto (the “Notice of Exercise”), duly executed by the Holder to the Company at its principal office, or at such other office as the Company may designate,
accompanied by payment, in cash by wire transfer of immediately available funds to the order of the Company and to an account designated by the Company (to be delivered prior to delivery of the Shares as provided for in Section 2(b) below), of
the amount obtained by multiplying the number of Shares designated in the Notice of Exercise by the Exercise Price (the “Purchase Price”). 

(b) Issuance of Certificates. As soon as practicable (but in no event later than three (3) business days) after the valid exercise
of this Warrant, in whole or in part, in accordance with Section 2(a) hereof, the Company, at its expense, shall cause to be issued in the name of and delivered to the Holder: (i) a certificate or certificates for (or, if the Shares are
then registered for public resale, by delivery through the facilities of the Depository Trust Company in electronic form of) the number of fully paid and non-assessable Shares to which the Holder shall be entitled upon such exercise and, if

 
applicable, (ii) a new warrant of like tenor to purchase all of the Shares that may be purchased pursuant to the portion, if any, of this Warrant not exercised by the Holder. The Holder
shall for all purposes hereof be deemed to have become the holder of record of such Shares on the date on which the Notice of Exercise and payment of the Purchase Price in accordance with Section 2(a) hereof were delivered and made,
respectively, irrespective of the date of delivery of such certificate or certificates, except that if the date of such delivery, notice and payment is a date when the stock transfer books of the Company are closed, the Holder shall be deemed to
have become the holder of record of such Shares at the close of business on the next succeeding date on which the stock transfer books are open. 

(c) Taxes. The issuance of the Shares upon the exercise of this Warrant, and the delivery of certificates or other instruments
representing such Shares, shall be made without charge to the Holder for any tax or other charge of whatever nature in respect of such issuance and the Company shall bear any such taxes in respect of such issuance. 

3. Adjustment of Exercise Price. 

(a) Adjustment for Reclassification, Consolidation, Merger, Sale or Transfer. If while this Warrant, or any portion hereof, remains
outstanding and unexpired there shall be (i) a reorganization or recapitalization (other than a combination, reclassification, exchange or subdivision of shares otherwise provided for herein), (ii) a merger or consolidation of the Company
with or into another corporation or other entity in which the Company shall not be the surviving entity, or a reverse merger in which the Company shall be the surviving entity but the shares of the Company’s capital stock outstanding
immediately prior to the merger or consolidation are converted by virtue of the merger or consolidation into other property, whether in the form of securities, cash or otherwise, or (iii) a sale or transfer of the Company’s properties and
assets as, or substantially as, an entirety to any other corporation or other entity in one transaction or a series of related transactions, then, as a part of such reorganization, recapitalization, merger, consolidation, sale or transfer, unless
otherwise directed by the Holder, all necessary or appropriate lawful provisions shall be made so that the Holder shall thereafter be entitled to receive upon exercise of this Warrant, during the period specified herein and upon payment of the
Exercise Price then in effect, the greatest number of shares of capital stock or other securities or property that a holder of the Shares deliverable upon exercise of this Warrant would have been entitled to receive in such reorganization,
recapitalization, merger, consolidation, sale or transfer if this Warrant had been exercised immediately prior to such reorganization, recapitalization, merger, consolidation, sale or transfer, all subject to further adjustment as provided in this
Section 3. If the per share consideration payable to the Holder for Shares in connection with any such transaction is in a form other than cash or marketable securities, then the value of such consideration shall be determined in good faith by
the Company’s board of directors. The foregoing provisions of this paragraph shall similarly apply to successive reorganizations, recapitalizations, mergers, consolidations, sales and transfers and to the capital stock or securities of any
other corporation or other entity that are at the time receivable upon the exercise of this Warrant. In all events, appropriate adjustment shall be made in the application of the provisions of this Warrant with respect to the rights and interests of
the Holder after the transaction, to the end that the provisions of this Warrant shall be applicable after that event, as near as reasonably may be, in relation to any shares or other property deliverable or issuable after such reorganization,
recapitalization, merger, consolidation, sale or transfer upon exercise of this Warrant. 
 (b) Adjustments for Split, Subdivision or
Combination of Shares. If while this Warrant, or any portion hereof, remains outstanding and unexpired the Company shall subdivide (by any stock split, stock dividend, recapitalization, reorganization, reclassification or otherwise) the shares
of Common Stock subject to acquisition hereunder, then, after the date of record for effecting such subdivision, the Exercise Price in effect immediately prior to such subdivision will be proportionately reduced and the number of shares of Common
Stock subject to acquisition upon exercise of this Warrant 

  
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will be proportionately increased. If the Company at any time combines (by reverse stock split, recapitalization, reorganization, reclassification or otherwise) the shares of Common Stock subject
to acquisition hereunder, then, after the record date for effecting such combination, the Exercise Price in effect immediately prior to such combination will be proportionately increased and the number of shares of Common Stock subject to
acquisition upon exercise of this Warrant will be proportionately decreased. 
 (c) Adjustments for Dividends in Stock or Other
Securities or Property. If while this Warrant, or any portion hereof, remains outstanding and unexpired, the holders of any class of securities as to which purchase rights under this Warrant exist at the time shall have received or, on or after
the record date fixed for the determination of eligible stockholders, shall have become entitled to receive, without payment therefor, other or additional stock or other securities or property (other than cash) of the Company by way of dividend,
then and in each case, this Warrant shall represent the right to acquire, in addition to the number of shares of such class of security receivable upon exercise of this Warrant, and without payment of any additional consideration therefor, the
amount of such other or additional stock or other securities or property (other than cash) of the Company that such holder would hold on the date of such exercise had it been the holder of record of the class of security receivable upon exercise of
this Warrant on the date hereof and had thereafter, during the period from the date hereof to and including the date of such exercise, retained such shares and/or all other additional stock available to it as aforesaid during said period, giving
effect to all adjustments called for during such period by the provisions of this Section 3. 
 (d) Notice of Adjustments. Upon
any adjustment of the Exercise Price and any increase or decrease in the number of Shares purchasable upon the exercise of this Warrant, then, and in each such case, the Company, within 30 days thereafter, shall give written notice thereof to the
Holder at the address of such Holder as shown on the books of the Company, which notice shall state the Exercise Price as adjusted and, if applicable, the increased or decreased number of Shares purchasable upon the exercise of this Warrant, setting
forth in reasonable detail the method of calculation of each. 
 4. Notices. Any notice or other communication required or permitted
to be given hereunder shall be in writing and shall be mailed by certified mail, return receipt requested, or delivered by facsimile transmission or by e-mail transmission, or delivered against receipt to the party to whom it is to be given
(a) if to the Company, at the address provided to the Holder, or (b) if to the Holder, at the address set forth in the Company’s records (or, in either case, to such other address as the party shall have furnished in writing in
accordance with the provisions of this Section 4). Any notice or other communication given by certified mail shall be deemed given at the time of receipt thereof. 

5. Legends. Each certificate evidencing the Shares issued upon exercise of this Warrant shall be stamped or imprinted with a legend
substantially in the following form: 
 THIS SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES
COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL
OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. 

  
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 6. Removal of Legend. Upon request of a holder of a certificate with the legends required
by Section 5 hereof, the Company shall issue to such holder a new certificate therefor free of any transfer legend, if, with such request, the Company shall have received an opinion of counsel satisfactory to the Company in form and substance
to the effect that any transfer by such holder of the Shares evidenced by such certificate will not violate the Act or any applicable state securities laws. 

7. Fractional Shares. No fractional Shares will be issued in connection with any exercise hereunder. Instead, the Company shall round
up, as nearly as practicable to the nearest whole Share, the number of Shares to be issued. 
 8. Rights of Stockholders. Except as
expressly provided in Section 3(c) hereof, the Holder, as such, shall not be entitled to vote or receive dividends or be deemed the holder of any of the Shares or any other securities of the Company that may at any time be issuable on the
exercise hereof for any purpose, nor shall anything contained herein be construed to confer upon the Holder, as such, any of the rights of a stockholder of the Company or any right to vote for the election of directors or upon any matter submitted
to stockholders at any meeting thereof, or to give or withhold consent to any corporate action (whether upon any recapitalization, issuance of stock, reclassification of stock, change of par value, consolidation, merger, conveyance, or otherwise) or
to receive notice of meetings, or otherwise until this Warrant shall have been exercised, in whole or in part, and the Shares purchasable upon such exercise hereof shall have been issued, as provided herein. 

9. Transfer. This Warrant and the Shares may not be offered for sale, sold, transferred, pledged or assigned without the prior written
consent of the Company. 
 10. Miscellaneous. 

(a) This Warrant and disputes arising hereunder shall be governed by and construed and enforced in accordance with the laws of the State of
Delaware applicable to agreements made and to be performed wholly within such State, without regard to its conflict of law rules. 
 (b) In
the event of any dispute, claim, question or disagreement arising from or relating to this Warrant or the breach thereof, the parties hereto agree to settle the dispute, claim, question or disagreement by arbitration before a single arbitrator in
Atlanta, Georgia, selected by, and such arbitration to be administered by, the American Arbitration Association (“AAA”) in accordance with its International Arbitration Rules, and judgment on the award rendered by the arbitrator may
be entered in any court having jurisdiction thereof. Each of the parties hereto agrees and acknowledges that all disputes between or among them are subject to the alternative dispute resolution procedures of this Section 10(b). Each of the
parties hereto agrees that any aspect of alternative dispute resolution not specifically covered in this Warrant shall be covered, without limitation, by the applicable AAA rules and procedures. Each of the parties hereto further agrees that any
determination by the arbitrator regarding any dispute, claim, question or disagreement arising from or relating to this Warrant shall be final and binding upon the parties hereto and shall not be subject to further appeal. 

(c) The headings in this Warrant are for purposes of reference only, and shall not limit or otherwise affect any of the terms hereof. 

(d) The covenants of the respective parties contained herein shall survive the execution and delivery of this Warrant. 

(e) The terms of this Warrant shall be binding upon and shall inure to the benefit of any successors or permitted assigns of the Company and
of the Holder or holder of the Shares issued or issuable upon the exercise hereof. 

  
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 (f) This Warrant and the other documents delivered pursuant hereto constitute the full and entire
understanding and agreement between the parties with regard to the subject hereof. 
 (g) The Company shall not, by amendment of its
Certificate of Incorporation, as amended, or Bylaws, adopted effective as of July 30, 2013, as amended, or through any other means, directly or indirectly, avoid or seek to avoid the observance or performance of any of the terms of this Warrant
and shall at all times in good faith assist in the carrying out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of the Holder contained herein against impairment. 

(h) Upon receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the
case of any such loss, theft or destruction, upon delivery of an indemnity agreement reasonably satisfactory in form and amount to the Company, or, in the case of any such mutilation, upon surrender and cancellation of such Warrant, the Company, at
its expense, will execute and deliver to the Holder, in lieu thereof, a new warrant of like date and tenor. 
 (i) This Warrant and any
provision hereof may be amended, waived or terminated only by an instrument in writing signed by the Company and the Holder. 

[Signature Page Follows] 

  
 5 

 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its duly
authorized officer. 
  

					
	HEDGEPATH PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Nicholas J. Virca

		 	Name:	 	Nicholas J. Virca
		 	Title:	 	President and Chief Executive Officer

 Exhibit A 

NOTICE OF EXERCISE 
  

	TO:	HedgePath Pharmaceuticals, Inc. 

 Attention: President 

The undersigned hereby elects to purchase                 
shares (“Shares”) of the common stock, par value $0.0001, of HedgePath Pharmaceuticals, Inc. (the “Company”) pursuant to the terms of this Warrant, and tenders herewith payment of the purchase price of such Shares
in full. 
 Please issue a certificate or certificates representing said shares in the name of the undersigned or in such other name as is
specified below: 
  

							
	 Name:
	 		 	  
	 	
				
	 Address:
	 		 	  
	 	
				
		 		 	  
	 	

 The undersigned hereby represents and warrants the following: 

(a) He/she/it (i) has such knowledge and experience in financial and business affairs that he/she/it is capable of evaluating the merits
and risks involved in purchasing the Shares, (ii) is able to bear the economic risks involved in purchasing the Shares, and (iii) is an “accredited investor,” as defined in Rule 501(a) of Regulation D promulgated under the
Securities Act of 1933, as amended; 
 (b) In making the decision to purchase the Shares, he/she/it has relied solely on independent
investigations made by him/her/it and has had the opportunity to ask questions of, and receive answers from, the Company concerning the Shares, the financial condition, prospective business and operations of the Company and has otherwise had an
opportunity to obtain any additional information, to the extent that the Company possess such information or could acquire it without unreasonable effort or expense; 

(c) His/her/its overall commitment to investments that are not readily marketable is not disproportionate to his/her/its net worth and income,
and the purchase of the Shares will not cause such overall commitment to become disproportionate; he/she/it can afford to bear the loss of the purchase price of the Shares; 

(d) He/she/it has no present need for liquidity in his/her/its investment in the Shares; and 

(e) He/she/it acknowledges that the transaction contemplated in connection with the purchase of the Shares has not been reviewed or approved
by the Securities and Exchange Commission or by any administrative agency charged with the administration of the securities laws of any state, and that no such agency has passed on or made any recommendation or endorsement of any of the securities
contemplated hereby. 
  

	
	  

	(Signature and Date)

 Exhibit B 

FORM OF ASSIGNMENT 
 FOR
VALUE RECEIVED,                      hereby sells, assigns and transfers to each assignee set forth below all of the rights of the undersigned under
the Warrant (as defined in and evidenced by the attached Warrant) to acquire the number of shares of the common stock, par value $0.0001, of HedgePath Pharmaceuticals, Inc. (“Shares”) set opposite the name of such assignee below and
in and to the foregoing Warrant with respect to said acquisition rights and the Shares issuable upon exercise of the Warrant: 
  

					
	 Name of Assignee
	  	 Address
	  	 Number of Shares

		  		  	
		  		  	
		  		  	
		  		  	

 If the total of the Shares described above are not all of the Shares evidenced by the foregoing Warrant, the
undersigned requests that a new warrant evidencing the right to acquire the Shares not so assigned be issued in the name of and delivered to the undersigned. 

 

			
	Name of Holder (print):	 	  

 
			
	(Signature):	 	  

 
			
	(By:)	 	  

 
			
	(Title:)	 	  

 
			
	Dated:Securities Purchase Agreement

 Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT 

Dated June 24, 2014 

by and between 

HEDGEPATH PHARMACEUTICALS, INC. 

and 
 MAYNE PHARMA
VENTURES PTY LTD 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	
	ARTICLE I	  
	 SALE OF PURCHASED SECURITIES; CLOSING
	  	 	2	  
			
	 1.1
	 	 Purchase
	  	 	2	  
	 1.2
	 	 Closing
	  	 	2	  
	
	ARTICLE II	  
	 DEFINITIONS
	  	 	2	  
			
	 2.1
	 	 Definitions
	  	 	2	  
	
	ARTICLE III	  
	 REPRESENTATIONS AND WARRANTIES
	  	 	7	  
			
	 3.1
	 	 Representations and Warranties of HPPI
	  	 	7	  
	 3.2
	 	 Representations and Warranties of Mayne Pharma
	  	 	19	  
	
	ARTICLE IV	  
	 CONDITIONS TO CLOSING
	  	 	20	  
			
	 4.1
	 	 Conditions to Mayne Pharma’s Obligations at the Closing
	  	 	20	  
	 4.2
	 	 Conditions to HPPI’s Obligations at the Closing
	  	 	22	  
	
	ARTICLE V	  
	 COVENANTS
	  	 	23	  
			
	 5.1
	 	 Commercially Reasonable Efforts
	  	 	23	  
	 5.2
	 	 Certain Notifications Until Closing
	  	 	23	  
	
	ARTICLE VI	  
	 ADDITIONAL AGREEMENTS
	  	 	23	  
			
	 6.1
	 	 Transfer Restrictions
	  	 	23	  
	 6.2
	 	 Integration
	  	 	24	  
	 6.3
	 	 Indemnification of Mayne Pharma, Etc
	  	 	25	  
	 6.4
	 	 Reservation of Common Stock
	  	 	26	  
	 6.5
	 	 Listing of Common Stock
	  	 	26	  
	 6.6
	 	 Certain Transactions and Confidentiality
	  	 	26	  
	 6.7
	 	 Acknowledgment of Dilution
	  	 	27	  
	 6.8
	 	 Equity Incentive Plan
	  	 	27	  
	 6.9
	 	 HPLLC Equity Investment
	  	 	27	  
	 6.10
	 	 Issuance of Make-Up Warrant
	  	 	27	  
	 6.11
	 	 Registration Rights
	  	 	27	  
	 6.12
	 	 Stock Certificate(s)
	  	 	27	  

  
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	ARTICLE VII	  
	 MISCELLANEOUS
	  	 	28	  
			
	 7.1
	 	 Termination
	  	 	28	  
	 7.2
	 	 Fees and Expenses
	  	 	28	  
	 7.3
	 	 Entire Agreement
	  	 	28	  
	 7.4
	 	 Notices
	  	 	28	  
	 7.5
	 	 Amendments; Waivers
	  	 	29	  
	 7.6
	 	 Headings
	  	 	30	  
	 7.7
	 	 Successors and Assigns
	  	 	30	  
	 7.8
	 	 No Third-Party Beneficiaries
	  	 	30	  
	 7.9
	 	 Governing Law
	  	 	30	  
	 7.10
	 	 Arbitration of Claims
	  	 	30	  
	 7.11
	 	 Survival
	  	 	30	  
	 7.12
	 	 Execution
	  	 	30	  
	 7.13
	 	 Severability
	  	 	31	  
	 7.14
	 	 Rescission and Withdrawal Right
	  	 	31	  
	 7.15
	 	 Replacement of Securities
	  	 	31	  
	 7.16
	 	 Remedies
	  	 	31	  
	 7.17
	 	 Payment Set Aside
	  	 	31	  
	 7.18
	 	 Saturdays, Sundays, Holidays, etc.
	  	 	32	  
	 7.19
	 	 Construction
	  	 	32	  
	 7.20
	 	 WAIVER OF JURY TRIAL
	  	 	32	  

  
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 LIST OF ANNEXES 

 

			
	ANNEX A:	    	FORM OF MAKE-UP WARRANT
		
	ANNEX B:	    	DISCLOSURE SCHEDULES
		
	ANNEX C:	    	FORM OF EQUITY HOLDERS AGREEMENT
		
	ANNEX D:	    	FORM OF AMENDED AND RESTATED SUPPLY AGREEMENT
		
	ANNEX E:	    	INDEMNIFICATION AGREEMENT
		
	ANNEX F:	    	REGISTRATION RIGHTS AGREEMENT

  
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 SECURITIES PURCHASE AGREEMENT 

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into this 24th day of June, 2014 (the “Signing Date”), by and between MAYNE PHARMA VENTURES PTY LTD, an Australian company ACN 168 896 357 (“Mayne Pharma”) and HEDGEPATH
PHARMACEUTICALS, INC., a Delaware corporation (“HPPI”). 
 RECITALS:  

A. As of the date hereof, HPPI has Three Hundred Forty Million (340,000,000) authorized shares of Common Stock and Ten Million
(10,000,000) authorized shares of Preferred Stock, of which Five Hundred Thousand (500,000) have been designated as Series A Convertible Preferred Stock. 

B. HPPI and Mayne Pharma International Pty. Ltd, an Australian company ACN 007 870 984 and predecessor-in-interest to Mayne Pharma
(“MPI”), entered into that certain Supply and License Agreement, dated as of September 3, 2013, as amended, including, without limitation, pursuant to that certain Amendment No. 1 to Supply and License Agreement and that
certain Amendment No. 2 to Supply and License Agreement (collectively, the “Supply Agreement”). 
 C. Prior to the
Signing Date, MPI assigned to Mayne Pharma, and Mayne Pharma assumed from MPI, the rights and obligations of MPI under the Supply Agreement. 

D. Pursuant to the Supply Agreement, Mayne Pharma has the right to terminate the Supply Agreement if HPPI did not obtain equity funding of at
least Five Million Dollars ($5,000,000), or lesser amount as agreed to by the parties, on or before May 30, 2014 (the “Termination Right”). 

E. The Supply Agreement further provides that HPPI is required to issue to Mayne Pharma certain shares of HPPI’s capital stock so that
Mayne Pharma will hold no less than thirty percent (30%) of the capital stock of HPPI on a fully diluted basis after the consummation of certain transactions as contemplated therein. 

F. On the terms and subject to the conditions set forth in this Agreement and in consideration for Mayne Pharma not exercising the Termination
Right, HPPI agrees to issue to Mayne Pharma in a private placement Two Hundred Fifty-Eight Thousand Three Hundred Sixty-Three and 280/1,000 (258,363.280) shares of HPPI’s Series A Convertible Preferred Stock (the “Preferred
Shares”) and a warrant to purchase Ten Million Two Hundred Fifty Thousand Five Hundred Sixty-Nine (10,250,569) shares of Common Stock, the substantial form of which is attached hereto as Annex A (the “Make-Up
Warrant” and, together with the Preferred Shares, the “Purchased Securities”), and Mayne Pharma intends to purchase from HPPI the Purchased Securities. 

G. Immediately following the Closing (as hereinafter defined), HPPI and HPLLC are entering in that certain Stock Purchase Agreement by and
between HPPI and HPLLC, pursuant 

 
to which, among other things, HPLLC is purchasing Twenty Million (20,000,000) shares of Common Stock in exchange the aggregate amount of One Million Five Hundred Thousand and 00/100 Dollars
($1,500,000.00), payable as set forth therein (collectively, the “HPLLC Equity Investment”). 
 H. HPPI and Mayne Pharma
expressly agree that the HPLLC Equity Investment shall satisfy the Termination Right. 
 I. Immediately following the closing of the HPLLC
Equity Investment, HPPI is issuing to Mayne Pharma the Make-Up Warrant in order to satisfy Mayne Pharma’s antidilution rights under the Supply Agreement. 

NOW, THEREFORE, in consideration of the mutual covenants contained in this Agreement, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, HPPI and Mayne Pharma agree as follows: 
 ARTICLE I 

SALE OF PURCHASED SECURITIES; CLOSING 

1.1 Purchase. On the terms and subject to the conditions set forth in this Agreement and in consideration for Mayne Pharma not
exercising the Termination Right, HPPI agrees to sell to Mayne Pharma, and Mayne Pharma agrees to purchase from HPPI, at the Closing, the Purchased Securities (the “Purchase”). 

1.2 Closing. 
 (a) On
the terms and subject to the conditions set forth in this Agreement, the closing of the Purchase and the transactions contemplated herein (the “Closing”) will take place on a date to be agreed upon by HPPI and Mayne Pharma; provided
that all of the conditions set forth in Article IV have been fulfilled or waived. The Closing shall take place at the office of HPPI’s Counsel (or remotely via the exchange of electronic documents and signatures), or at such other place as HPPI
and Mayne Pharma may mutually agree. The time and date on which the Closing occurs is referred to in this Agreement as the “Closing Date”. 

(b) Subject to the fulfillment or waiver of the conditions set forth in Section 4.2 hereof, (i) at the Closing, HPPI will
deliver to Mayne Pharma the Preferred Shares, as evidenced by one or more certificates dated the Closing Date and bearing appropriate legends as hereinafter provided for, and (ii) immediately following the closing of the HPLLC Equity
Investment, the Make-Up Warrant, bearing an appropriate legend as hereinafter provided for. 
 ARTICLE II 

DEFINITIONS 
 2.1
Definitions. For all purposes of this Agreement, the following terms will have the following meanings: 
 “AAA”
shall have the meaning ascribed to such term in Section 7.10 hererof. 

  
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 “Action” means an action, charge, claim, complaint, dispute, suit, arbitration,
inquiry, notice of violation, investigation, or proceeding (including, without limitation, an informal investigation or partial proceeding, such as a deposition), whether commenced, threatened, legal, administrative or regulatory. 

“Affiliate” or “Affiliated” means any Person that, directly or indirectly through one or more
intermediaries, controls or is controlled by or is under common control with a Person, as such terms are used in and construed under Rule 405 under the Securities Act. 

“Agreement” shall have the meaning ascribed to such term in this first paragraph of this Agreement. 

“Amended Supply Agreement” shall have the meaning ascribed to such term in Section 4.1(p) hereof. 

“BHCA” shall have the meaning ascribed to such term in Section 3.1(ll) hereof. 

“Board of Directors” means the board of directors of HPPI. 

“Business Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States
or any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to close. 

“Closing” shall have the meaning ascribed to such term in Section 1.2(a) hereof. 

“Closing Date” shall have the meaning ascribed to such term in Section 1.2(a) hereof. 

“Code” means the Internal Revenue Code of 1986, as amended. 

“Commission” means the United States Securities and Exchange Commission. 

“Common Stock” means the common stock of HPPI, par value $0.0001 per share, and any other class of securities into which such
securities may hereafter be reclassified or changed. 
 “Common Stock Equivalents” means any securities of HPPI or the
Subsidiaries which would entitle the holder thereof to acquire at any time Common Stock, including, without limitation, any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or
exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock. 
 “Conversion Shares” means the
shares of Common Stock issuable upon the conversion, in whole or in part, of the Preferred Shares. 
 “Disclosure
Schedules” shall have the meaning ascribed to such term in Section 3.1 hereof. 
 “Disqualification
Event” shall have the meaning ascribed to such term in Section 3.1(nn) hereof. 

  
 3 

 “EIP” means the HPPI 2014 Equity Incentive Plan. 

“Equity Holders Agreement” shall have the meaning ascribed to such term in Section 4.1(g) hereof. 

“Evaluation Date” shall have the meaning ascribed to such term in Section 3.1(r) hereof. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 “FCPA” means the Foreign Corrupt Practices Act of 1977, as amended. 

“FDA” shall have the meaning ascribed to such term in Section 3.1(ii) hereof. 

“FDCA” shall have the meaning ascribed to such term in Section 3.1(ii) hereof. 

“Federal Reserve” shall have the meaning ascribed to such term in Section 3.1(ll) hereof. 

“GAAP” shall have the meaning ascribed to such term in Section 3.1(h) hereof. 

“Governmental Authority(ies)” means any foreign, domestic, federal, territorial, state or local governmental authority,
quasi-governmental authority, instrumentality, court, legislative body, government or self-regulatory organization, commission, court, tribunal or organization or any regulatory, administrative or other agency, or any political or other subdivision,
department or branch of any of the foregoing. 
 “HPLLC” means Hedgepath, LLC, a Florida limited liability company. 

“HPLLC Equity Investment” shall have the meaning ascribed to such term in the Recitals. 

“HPLLC Loans” means those certain loans in the aggregate amount of Six Hundred Thirty-Nine Thousand Seven Hundred Sixty-Seven
and 00/100 Dollars ($639,767) advanced by HPLLC to HPPI. 
 “HPLLC Warrant” means that certain warrant to purchase an
aggregate of Ten Million Two Hundred Fifty Thousand Five Hundred Sixty-Nine (10,250,569) shares of Common Stock. 

“HPPI” shall have the meaning ascribed to such term in the first paragraph of this Agreement. 

“HPPI’s Counsel” means Ellenoff Grossman & Schole LLP, with offices located at 1345 Avenue of the Americas, New
York, New York 10105-0302. 
 “Indebtedness” shall have the meaning ascribed to such term in Section 3.1(aa)
hereof. 
 “Intellectual Property Rights” shall have the meaning ascribed to such term in Section 3.1(o)
hereof. 

  
 4 

 “Issuer Covered Person(s)” shall have the meaning ascribed to such term in
Section 3.1(nn) hereof. 
 “Liens” means a lien, charge pledge, security interest, encumbrance, right of first
refusal, preemptive right or other restriction. 
 “Make-Up Warrant” shall have the meaning ascribed to such term in the
Recitals. 
 “Make-Up Warrant Shares” means the shares of Common Stock issuable upon exercise, in whole or in part, of the
Make-Up Warrant. 
 “Material Adverse Effect” means (i) a material adverse effect on the legality, validity or
enforceability of any Transaction Document, (ii) a material adverse effect on the results of operations, assets, business, prospects or condition (financial or otherwise) of HPPI and the Subsidiaries, or (iii) a material adverse effect on
HPPI’s ability to perform in any material respect on a timely basis its obligations under any Transaction Document. 
 “Mayne
Pharma” shall have the meaning ascribed to such term in this first paragraph of this Agreement. 
 “Mayne Pharma
Party(ies)” shall have the meaning ascribed to such term in Section 6.3 hereof. 
 “Money Laundering
Laws” shall have the meaning ascribed to such term in Section 3.1(mm) hereof. 
 “MPI” shall have the
meaning ascribed to such term in the Recitals. 
 “Person” means an individual or corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability company, joint stock company, Governmental Authority or other entity of any kind. 

“Pharmaceutical Product” shall have the meaning ascribed to such term in Section 3.1(ii) hereof. 

“Preferred Shares” shall have the meaning ascribed to such term in the Recitals. 

“Preferred Stock” means the preferred stock of HPPI, par value $0.0001 per share, and any other class of securities into
which such securities may hereafter be reclassified or changed. 
 “Purchase” shall have the meaning ascribed to such term
in Section 1.1 hereof. 
 “Purchased Securities” shall have the meaning ascribed to such term in the Recitals.

 “Registration Rights Agreement”’ shall have the meaning ascribed to such term in Section 6.11 hereof.

 “Regulatory Permit” shall have the meaning ascribed to such term in Section 3.1(m) hereof. 

  
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 “Required Approvals” shall have the meaning ascribed to such term in
Section 3.1(e) hereof. 
 “Rule 144” means Rule 144 promulgated by the Commission pursuant to the Securities
Act, as such rule may be amended or interpreted from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same purpose and effect as such rule. 

“SEC Reports” shall have the meaning ascribed to such term in Section 3.1(h) hereof. 

“Securities” means the Purchased Securities, the Conversion Shares and the Make-Up Warrant Shares. 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

“Series A Convertible Preferred Stock” shall have the meaning ascribed to such term in Section 3.1(g)(i). 

“Signing Date” shall have the meaning ascribed to such term in the first paragraph of this Agreement. 

“Subsidiary(ies)” means any subsidiary of HPPI as set forth on Schedule 3.1(a) and shall, where applicable, also
include any direct or indirect subsidiary of HPPI formed or acquired after the Signing Date. 
 “Supply Agreement” shall
have the meaning ascribed to such term in the Recitals. 
 “Termination Right” shall have the meaning ascribed to such term
in the Recitals. 
 “Trading Day” means a day on which the principal Trading Market is open for trading. 

“Trading Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange or the OTC Bulletin Board (or any successors to any of the foregoing). 

“Transaction Documents” means this Agreement, the Make-Up Warrant, the Equity Holders Agreement, all exhibits, annexes, and
schedules thereto and hereto and any other documents or agreements executed in connection with the transactions contemplated hereunder. 

“Transfer Agent” means Computershare Trust Company, Inc., the current transfer agent of HPPI, with a mailing address of 350
Indiana Street, Suite 800, Golden, Colorado 80401 and a facsimile number of (201) 680-4665, and any successor transfer agent of HPPI. 

“Virca” shall have the meaning ascribed to such term in Section 4.1(k) hereof. 

  
 6 

 ARTICLE III 

REPRESENTATIONS AND WARRANTIES 

3.1 Representations and Warranties of HPPI. Except as set forth in the Disclosure Schedules attached hereto as Annex B and
deemed a part hereof (“Disclosure Schedules”), and except as disclosed in the SEC Reports, HPPI hereby represents and warrants to Mayne Pharma that each of the following representations and warranties (i) is true and correct as
of the Signing Date (except as otherwise indicated), (ii) will be true and correct as of the Closing Date (except as otherwise indicated), and (iii) with respect to the Make-Up Warrant, will be true and correct as of the closing date of
the HPLLC Equity Investment. 
 (a) Subsidiaries. All of the direct and indirect subsidiaries of HPPI are set forth on Schedule
3.1(a). HPPI owns, directly or indirectly, all of the capital stock or other equity interests of each Subsidiary (if any) free and clear of any Liens, and all of the issued and outstanding shares of capital stock of each Subsidiary are validly
issued and are fully paid, non-assessable and free of preemptive and similar rights to subscribe for or purchase securities. If HPPI has no subsidiaries, all other references to the Subsidiaries or any of them in the Transaction Documents shall be
disregarded. 
 (b) Organization and Qualification. HPPI and each of the Subsidiaries is an entity duly incorporated or otherwise
organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization, with the requisite power and authority to own and use its properties and assets and to carry on its business as currently
conducted. Neither HPPI nor any Subsidiary is in violation nor default of any of the provisions of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents. Each of HPPI and the Subsidiaries is
duly qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except where the
failure to be so qualified or in good standing, as the case may be, could not have or reasonably be expected to result in a Material Adverse Effect, and no Action has been instituted in any such jurisdiction revoking, limiting or curtailing or
seeking to revoke, limit or curtail such power and authority or qualification. 
 (c) Authorization, Enforcement. HPPI has the
requisite corporate power and authority to enter into and to consummate the transactions contemplated by this Agreement and each of the other Transaction Documents and otherwise to carry out its obligations hereunder and thereunder (which includes
the issuance of the Securities). The execution, delivery and performance of each of this Agreement and the other Transaction Documents by HPPI and the consummation by it of the transactions contemplated hereby and thereby have been duly authorized
by all necessary action on the part of HPPI and no further approval or authorization is required by HPPI, the Board of Directors or HPPI’s stockholders in connection herewith or therewith other than in connection with the Required Approvals.
This Agreement and each other Transaction Document to which HPPI is a party has been (or upon delivery will have been) duly executed by HPPI, and when delivered in accordance with the terms hereof and thereof, will constitute the valid and binding
obligation of HPPI enforceable against HPPI in accordance with their respective terms. 

  
 7 

 (d) No Conflicts. The execution, delivery and performance by HPPI of this Agreement and
the other Transaction Documents to which it is a party, the issuance and sale of any of the Securities, and the consummation by HPPI of the transactions contemplated hereby and thereby do not and will not: (i) conflict with or violate any
provision of HPPI’s or any Subsidiary’s certificate or articles of incorporation, bylaws or other organizational or charter documents, (ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both
would become a default) under, result in the creation of any Lien upon any of the properties or assets of HPPI or any Subsidiary, or give to others any rights of termination, amendment, acceleration or cancellation (with or without notice, lapse of
time or both) of, any agreement, credit facility, debt or other instrument (evidencing a debt of HPPI or a Subsidiary or otherwise) or other understanding to which HPPI or any Subsidiary is a party or by which any property or asset of HPPI or any
Subsidiary is bound or affected, or (iii) subject to the Required Approvals, conflict with or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any Governmental Authority to which
HPPI or a Subsidiary is subject (including federal and state securities laws and regulations), or by which any property or asset of HPPI or a Subsidiary is bound or affected. 

(e) Filings, Consents and Approvals. HPPI is not required to obtain any consent, waiver, authorization or order of, give any notice
to, or make any filing or registration with, any Governmental Authority or other Person in connection with the execution, delivery and performance by HPPI of the Transaction Documents, other than: (i) the filings required pursuant to
Section 6.2 of this Agreement and (ii) the filing of Form D with the Commission and such filings as are required to be made under applicable state securities laws (collectively, the “Required Approvals”). 

(f) Issuance of Securities. 

(i) The Preferred Shares are duly authorized, and, when issued and delivered pursuant to this Agreement, will be duly and validly issued,
fully paid and nonassessable, free and clear of all Liens other than restrictions on transfer provided for in the Transaction Documents. The Conversion Shares have been duly authorized and reserved for issuance upon conversion of the Preferred
Shares and when so issued will be validly issued, fully paid and non-assessable, free and clear of all Liens other than restrictions on transfer provided for in the Transaction Documents. HPPI has no series or class of capital stock, whether or not
issued or outstanding, that will, upon issuance of the Preferred Shares, rank senior to the Preferred Shares with respect to the payment of dividends or the distribution of assets in the event of any dissolution, liquidation or winding up of HPPI.

 (ii) The Make-Up Warrant has been duly authorized and, when executed and delivered as contemplated hereby, will constitute a valid and
legally binding obligation of HPPI in accordance with its terms, and the Make-Up Warrant Shares have been duly authorized and reserved for issuance upon exercise of the Make-Up Warrant and when so issued in accordance with the terms thereof will be
validly issued, fully paid and non-assessable, free and clear of all Liens other than restrictions on transfer provided for in the Transaction Documents. 

(iii) HPPI has reserved from its duly authorized capital stock the maximum number of shares of Common Stock issuable upon the conversion of
all of the Preferred Shares and the full exercise of the Make-Up Warrant. 

  
 8 

 (g) Capitalization. 

(i) The authorized capital stock of HPPI, as of the Signing Date and effective immediately prior to the Closing, consists of (i) Three
Hundred Forty Million (340,000,000) shares of Common Stock, of which (A) Eighteen Million Eight Hundred Eighty-Eight Thousand Nine Hundred Seventy-One (18,888,971) shares are issued and outstanding and (B) no shares are held in
treasury, and (ii) Ten Million (10,000,000) shares of Preferred Stock, of which (A) Five Hundred Thousand (500,000) shares are designated as “Series A Convertible Preferred Stock” (“Series A Convertible
Preferred Stock”), One Hundred Seventy Thousand and 739/1000 (170,000.739) shares of which are issued and outstanding and (B) no shares are held in treasury. As of the Signing Date and effective immediately prior to the Closing,
no shares of Common Stock or Preferred Stock are reserved for issuance, except for (1) Ten Million Two Hundred Fifty Thousand Five Hundred Sixty-Nine (10,250,569) shares of Common Stock reserved for issuance pursuant to the Make-Up
Warrant, and (2) Ten Million Two Hundred Fifty Thousand Five Hundred Sixty-Nine (10,250,569) shares of Common Stock reserved for issuance pursuant to the HPLLC Warrant. 

(ii) Schedule 3.1(g) sets forth the capitalization of HPPI immediately prior to the Closing, immediately following the Closing, and
immediately following the consummation of the HPLLC Equity Investment, and, in each case, shall include (A) all issued and outstanding Common Stock, including, with respect to any restricted Common Stock, any vesting schedule and repurchase
price; (B) all granted stock options, including any vesting schedule and exercise price; (C) all shares of Common Stock to be reserved for future award grants under the EIP; (D) each series and all shares of issued and outstanding
Preferred Stock and shares of Common Stock issuable upon conversion of such shares of Preferred Stock; (E) all granted warrants or other stock purchase rights, if any; and (F) the number of shares of Common Stock owned beneficially, and of
record, by Affiliates of HPPI. 
 (iii) HPPI has not issued any capital stock since its most recently filed periodic report under the
Exchange Act. No Person has any right of first refusal, preemptive right, right of participation, or any similar right to participate in the transactions contemplated by the Transaction Documents. Except as set forth on the Disclosure Schedules,
there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or giving any Person
any right to subscribe for or acquire any shares of Common Stock or Preferred Stock or any other securities of HPPI, or contracts, commitments, understandings or arrangements by which HPPI or any Subsidiary is or may become bound to issue additional
shares of Common Stock, any Common Stock Equivalents or any other securities of HPPI. The issuance and sale of any of the Securities will not obligate HPPI to issue any shares of Common Stock or Preferred Stock or other securities of HPPI to any
Person (other than Mayne Pharma) and will not result in a right of any holder of HPPI’s securities to adjust the exercise, conversion, exchange or reset price under any of such securities. All of the outstanding shares of capital stock of HPPI
are duly authorized, validly issued, fully paid and nonassessable, 

  
 9 

 
have been issued in compliance with all federal and state securities laws, and none of such outstanding shares was issued in violation of any preemptive rights, rights of first refusal or other
similar rights to subscribe for or purchase securities (or is subject to any preemptive rights, rights of first refusal or other similar rights to subscribe for or purchase securities). 

(iv) No further approval or authorization of any stockholder, the Board of Directors or any other Person is required for the issuance and
sale of any of the Securities. There are no stockholders agreements, voting agreements or other similar agreements with respect to HPPI’s capital stock to which HPPI is a party or, to the knowledge of HPPI, between or among any of HPPI’s
stockholders. 
 (h) SEC Reports; Financial Statements. HPPI has, since August 12, 2013, filed all reports, schedules, forms,
statements and other documents required to be filed by HPPI under the Securities Act and the Exchange Act, including pursuant to Section 13(a), 14(a) or 15(d) thereof (the foregoing materials, including the exhibits thereto and documents
incorporated by reference therein, being collectively referred to herein as the “SEC Reports” and each an “SEC Report”), on a timely basis or has received a valid extension of such time of filing and has filed any
such SEC Reports prior to the expiration of any such extension. As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Securities Act and the Exchange Act, as applicable, and none of the SEC
Reports, when they became effective or were filed, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the
circumstances under which they were made, not misleading. The financial statements of HPPI included in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the Commission with
respect thereto as in effect at the time of filing. Such financial statements have been prepared in accordance with United States generally accepted accounting principles applied on a consistent basis during the periods involved
(“GAAP”), except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may not contain all footnotes required by GAAP, and fairly present in all material
respects the financial position of HPPI and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial,
year-end audit adjustments. 
 (i) Material Changes; Undisclosed Events, Liabilities or Developments. Since August 12, 2013,
except as specifically disclosed in a subsequent SEC Report filed at least three (3) Business Days prior to the date hereof: (i) there has been no event, liability, fact, circumstance, occurrence or development that, individually or in the
aggregate, has had or could reasonably be expected to result in a Material Adverse Effect, (ii) HPPI has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accrued expenses incurred in the ordinary
course of business consistent with past practice and (B) liabilities not required to be reflected in HPPI’s financial statements pursuant to GAAP or disclosed in filings made with the Commission, (iii) HPPI has not altered its method
of accounting, (iv) HPPI has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock and (v) HPPI
has not issued any equity securities to any officer, director or Affiliate. HPPI does not have pending before the Commission any request for confidential treatment of information. No 

  
 10 

 
event, liability, fact, circumstance, occurrence or development has occurred or exists, or is reasonably expected to occur or exist, with respect to HPPI or its Subsidiaries or their respective
businesses, properties, operations, assets or financial condition, that would be required to be disclosed by HPPI under applicable securities laws at the time this representation is made or deemed made that has not been publicly disclosed at least
one (1) Trading Day prior to the date that this representation is made. 
 (j) Litigation. Except as described in Schedule
3.1(j), there is no Action active, pending or, to the knowledge of HPPI, threatened against or affecting HPPI, any Subsidiary or Affiliate of HPPI or any of their respective properties before or by any arbitrator or Governmental Authority which,
individually or in the aggregate, (i) adversely affects or challenges the legality, validity or enforceability of any of the Transaction Documents or the Securities or (ii) could, if there were an unfavorable decision, have or reasonably
be expected to result in a Material Adverse Effect. Neither HPPI nor any Subsidiary, nor any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liability under federal or state securities laws
or a claim of breach of fiduciary duty. There has not been, and to the knowledge of HPPI, there is not pending or contemplated, any investigation by the Commission involving HPPI or any current or former director or officer of HPPI. The Commission
has not issued any stop order or other order suspending the effectiveness of any registration statement filed by HPPI or any Subsidiary under the Exchange Act or the Securities Act. 

(k) Labor Relations. No labor dispute exists or, to the knowledge of HPPI, is imminent with respect to any of the employees of HPPI,
which could reasonably be expected to result in a Material Adverse Effect. None of HPPI’s or its Subsidiaries’ employees is a member of a union that relates to such employee’s relationship with HPPI or such Subsidiary, and neither
HPPI nor any of its Subsidiaries is a party to a collective bargaining agreement, and HPPI and its Subsidiaries believe that their relationships with their employees are good. To the knowledge of HPPI, no executive officer of HPPI or any Subsidiary
is, or is now expected to be, in violation of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement or non-competition agreement, or any other contract or agreement or any restrictive covenant
in favor of any third party, and the continued employment of each such executive officer does not subject HPPI or any of its Subsidiaries to any liability with respect to any of the foregoing matters. HPPI and its Subsidiaries are in compliance with
all U.S. federal, state, local and foreign laws and regulations relating to employment and employment practices, terms and conditions of employment and wages and hours. 

(l) Compliance. Neither HPPI nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has
not been waived that, with notice or lapse of time or both, would result in a default by HPPI or any Subsidiary under), nor has HPPI or any Subsidiary received notice of a claim that it is in default under or that it is in violation of, any
indenture, loan or credit agreement or any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any judgment,
decree, or order of any arbitrator or Governmental Authority or (iii) is or has been in violation of any statute, rule, ordinance or regulation of any Governmental Authority, including without limitation all foreign, federal, state and local
laws relating to taxes, environmental protection, occupational health and safety, product quality and safety and employment and labor matters except, in the case of clauses (ii) and (iii) above, where the violation would not reasonably be
expected to result in a Material Adverse Effect. 

  
 11 

 (m) Regulatory Permits. HPPI and the Subsidiaries possess all certificates,
authorizations and permits issued by the appropriate Governmental Authorities necessary to conduct their respective businesses as described in the SEC Reports (each a “Regulatory Permit”), and neither HPPI nor any Subsidiary has
received any notice of Actions relating to the revocation or modification of any Regulatory Permit. 
 (n) Title to Assets. HPPI and
the Subsidiaries have good and marketable title in fee simple to all real property owned by them and good and marketable title in all personal property owned by them that is material to the business of HPPI and the Subsidiaries, in each case free
and clear of all Liens, except for (i) Liens as do not materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by HPPI and the Subsidiaries and (ii) Liens for
the payment of federal, state or other taxes, for which appropriate reserves have been made therefor in accordance with GAAP and the payment of which is neither delinquent nor subject to penalties. Any real property and facilities held under lease
by HPPI and the Subsidiaries are held by them under valid, subsisting and enforceable leases with which HPPI and the Subsidiaries are in compliance. 

(o) Intellectual Property. Subject to the conditional use of the Intellectual Property Rights permitted by Mayne Pharma to HPPI
pursuant to the Supply Agreement, HPPI and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark applications, service marks, trade names, trade secrets, inventions, copyrights, licenses and other
intellectual property rights and similar rights (collectively, the “Intellectual Property Rights”) as necessary or required for use in connection with their respective businesses. None of, and neither HPPI nor any Subsidiary has
received a notice (written or otherwise) that any of, the Intellectual Property Rights of HPPI and the Subsidiaries has expired, terminated or been abandoned, or is expected to expire or terminate or be abandoned, within two (2) years from the
date of this Agreement. Neither HPPI nor any Subsidiary has received, since August 12, 2013, a written notice of a claim or otherwise has any knowledge that the Intellectual Property Rights of HPPI or any of the Subsidiaries violate or infringe
upon the rights of any Person. To the knowledge of HPPI and subject to the conditional use of the Intellectual Property Rights permitted by Mayne Pharma to HPPI pursuant to the Supply Agreement, all Intellectual Property Rights of HPPI and the
Subsidiaries are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights of HPPI and the Subsidiaries. HPPI and its Subsidiaries have taken commercially reasonable security measures to protect
the secrecy, confidentiality and value of all of their Intellectual Property Rights. 
 (p) Insurance. HPPI and the Subsidiaries are
insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in the businesses in which HPPI and the Subsidiaries are engaged, including, but not limited to, directors and
officers insurance coverage at least equal to Two Million ($2,000,000.00); provided, however that, upon approval by the Board of Directors, such coverage shall be increased to Five Million Dollars ($5,000,000) on or before
September 30, 2014. Neither HPPI nor any Subsidiary has any reason to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be
necessary to continue its business without a significant increase in cost. 

  
 12 

 (q) Transactions With Affiliates and Employees. Except as set forth in the SEC Reports,
none of the officer, directors or employees of HPPI or any Subsidiary is presently a party to any transaction with HPPI or any Subsidiary (other than for services as employees, officers and directors), including any contract, agreement or other
arrangement providing for the furnishing of services to or by, providing for rental of real or personal property to or from, providing for the borrowing of money from or lending of money to or otherwise requiring payments to or from any officer,
director or such employee or any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director, trustee, stockholder, member or partner, other than for: (i) payment of reasonable salary or
consulting fees for services rendered, (ii) reimbursement for reasonable expenses incurred on behalf of HPPI and (iii) other employee benefits, including stock option agreements under any stock option plan of HPPI. 

(r) Sarbanes-Oxley; Internal Accounting Controls. HPPI and the Subsidiaries are in compliance with any and all applicable requirements
of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof, and any and all applicable rules and regulations promulgated by the Commission thereunder that are effective as of the date hereof and as of the Closing Date. HPPI and the
Subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance that: (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are
recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s general or specific authorization,
and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. HPPI and the Subsidiaries have established disclosure controls and
procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for HPPI and the Subsidiaries and designed such disclosure controls and procedures to ensure that information required to be disclosed by HPPI in the reports it files or submits
under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Commission’s rules and forms. HPPI’s certifying officers have evaluated the effectiveness of the disclosure controls and
procedures of HPPI and the Subsidiaries as of the end of the period covered by the most recently filed periodic report under the Exchange Act (such date, the “Evaluation Date”). HPPI presented in its most recently filed periodic
report under the Exchange Act the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date. Since the Evaluation Date, there have been no changes in
the internal control over financial reporting (as such term is defined in the Exchange Act) of HPPI and its Subsidiaries that have materially affected, or are reasonably likely to materially affect, the internal control over financial reporting of
HPPI or its Subsidiaries. 
 (s) Certain Fees. No brokerage or finder’s fees or commissions are or will be payable by HPPI or
any Subsidiary to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or other Person with respect to the transactions contemplated by the Transaction Documents. Mayne Pharma shall have no obligation with
respect to any fees or with respect to any claims made by or on behalf of other Persons for fees of a type contemplated in this Section 3.1(s) that may be due in connection with the transactions contemplated by the Transaction Documents.

  
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 (t) Private Placement. Assuming the accuracy of Mayne Pharma’s representations and
warranties set forth in Section 3.2 hereof, no registration under the Securities Act is required for the offer, sale or issuance of any of the Securities, by HPPI to Mayne Pharma as contemplated hereby. The offer, sale and issuance of
any of the Securities hereunder, or otherwise, do not contravene the rules and regulations of the Trading Market. 
 (u) Investment
Company. HPPI is not, and is not an Affiliate of, and immediately after the Purchase, will not be or be an Affiliate of, an “investment company” within the meaning of the Investment Company Act of 1940, as amended. HPPI shall conduct
its business in a manner so that it will not become an “investment company” subject to registration under the Investment Company Act of 1940, as amended. 

(v) Registration Rights. No Person has any right to cause HPPI to effect the registration under the Securities Act of any securities
of HPPI or any Subsidiary. 
 (w) Listing and Maintenance Requirements. The Common Stock is registered pursuant to
Section 12(b) or 12(g) of the Exchange Act, and HPPI has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act nor has HPPI received any
notification that the Commission is contemplating terminating such registration. HPPI has not, since August 12, 2013, received notice from any Trading Market on which the Common Stock is or has been listed or quoted to the effect that HPPI is
not in compliance with the listing or maintenance requirements of such Trading Market. HPPI is, and has no reason to believe that it will not in the foreseeable future continue to be, in compliance with all such listing and maintenance requirements.
The Common Stock is currently eligible for electronic transfer through the Depository Trust Company or another established clearing corporation and HPPI is current in payment of the fees to the Depository Trust Company (or such other established
clearing corporation) in connection with such electronic transfer. 
 (x) Application of Takeover Protections. HPPI and the Board of
Directors have taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar
anti-takeover provision under HPPI’s amended and restated certificate of incorporation (or similar charter documents) or the laws of the State of Delaware that is or could become applicable to Mayne
Pharma as a result of Mayne Pharma and HPPI fulfilling their obligations or exercising their rights under the Transaction Documents, including without limitation as a result of HPPI’s issuance of the Securities and Mayne Pharma’s ownership
of the Securities. 
 (y) Disclosure. All of the disclosures furnished by or on behalf of HPPI to Mayne Pharma regarding HPPI and
HPPI’s Subsidiaries, their respective businesses and the transactions contemplated hereby, including the Disclosure Schedules, and all of the representations and warranties of HPPI contained herein, are true and correct and do not contain any
untrue statement of a material fact or omit to state any material fact necessary in order to 

  
 14 

 
make the statements made therein, in light of the circumstances under which they were made, not misleading. The press releases disseminated by HPPI during the twelve months preceding the date of
this Agreement taken as a whole do not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which
they were made and when made, not misleading. HPPI acknowledges and agrees that Mayne Pharma does not make or has not made any representations or warranties with respect to the transactions contemplated by the Transaction Documents other than those
specifically set forth in Section 3.2 hereof. 
 (z) No Integrated Offering. Assuming the accuracy of Mayne
Pharma’s representations and warranties set forth in Section 3.2 hereof, neither HPPI, nor any of its Affiliates, nor any Person acting on its or their behalf has, directly or indirectly, made any offers or sales of any security or
solicited any offers to buy any security, under circumstances that would cause this offering of the Purchased Securities to be integrated with prior offerings by HPPI for purposes of the Securities Act which would require the registration of any
such securities under the Securities Act. 
 (aa) Solvency. Based on the consolidated financial condition of HPPI as of the Closing
Date, after giving effect to the HPLLC Equity Investment: (i) the fair saleable value of HPPI’s assets exceeds the amount that will be required to be paid on or in respect of HPPI’s existing debts and other liabilities (including
known contingent liabilities) as they mature, (ii) HPPI’s assets do not constitute unreasonably small capital to carry on its business as now conducted and as proposed to be conducted including its capital needs taking into account the
particular capital requirements of the business conducted by HPPI, consolidated and projected capital requirements and capital availability thereof, and (iii) the current cash flow of HPPI, together with the proceeds HPPI would receive, were it
to liquidate all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect of its liabilities when such amounts are required to be paid. HPPI does not intend to incur debts
beyond its ability to pay such debts as they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt). HPPI has no knowledge of any facts or circumstances which lead it to believe that it will file for
reorganization or liquidation under the bankruptcy or reorganization laws of any jurisdiction within one year from the Closing Date. Schedule 3.1(aa) sets forth as of the date hereof all outstanding secured and unsecured Indebtedness of HPPI
or any Subsidiary, or for which HPPI or any Subsidiary has commitments. For the purposes of this Agreement, “Indebtedness” means (x) any liabilities for borrowed money or amounts owed in excess of Fifty Thousand and 00/100
Dollars ($50,000) (other than trade accounts payable incurred in the ordinary course of business), (y) all guaranties, endorsements and other contingent obligations in respect of indebtedness of others, whether or not the same are or should be
reflected in HPPI’s consolidated balance sheet (or the notes thereto), except guaranties by endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; and (z) the present
value of any lease payments in excess of Fifty Thousand and 00/100 Dollars ($50,000) due under leases required to be capitalized in accordance with GAAP. Neither HPPI nor any Subsidiary is in default with respect to any Indebtedness. 

(bb) Tax Status. Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a
Material Adverse Effect, HPPI and its 

  
 15 

 
Subsidiaries each (i) has made or filed all United States federal, state and local income and all foreign income and franchise tax returns, reports and declarations required by any
jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to be due on such returns, reports and declarations, and (iii) has set aside on
its books provision reasonably adequate for the payment of all material taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaid taxes in any material amount claimed to be due by the
taxing authority of any jurisdiction, and the officers of HPPI or of any Subsidiary know of no basis for any such claim. 
 (cc) No
General Solicitation. Neither HPPI nor any Person acting on behalf of HPPI has offered or sold any of the Securities by any form of general solicitation or general advertising. HPPI has offered the Securities for sale or issuance only to Mayne
Pharma. 
 (dd) Foreign Corrupt Practices. Neither HPPI nor any Subsidiary or, to the knowledge of HPPI or any Subsidiary, any agent
or other Person acting on behalf of HPPI or any Subsidiary, has: (i) directly or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity,
(ii) made any unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by HPPI or any
Subsidiary (or made by any Person acting on its behalf of which HPPI is aware) which is in violation of any law or (iv) violated any provision of the FCPA. 

(ee) Accountants. HPPI’s accounting firm is set forth on Schedule 3.1(ee) of the Disclosure Schedules. To the knowledge
and belief of HPPI, such accounting firm: (i) is a registered public accounting firm as required by the Exchange Act and (ii) shall express its opinion with respect to the financial statements to be included in HPPI’s annual report
for the fiscal year ending December 31, 2013. 
 (ff) No Disagreements with Accountants and Lawyers. There are no disagreements
of any kind presently existing, or reasonably anticipated by HPPI to arise, between HPPI and the accountants and lawyers formerly or presently employed by HPPI and HPPI is current with respect to any fees owed to its accountants and lawyers which
could affect HPPI’s ability to perform any of its obligations under any of the Transaction Documents. 
 (gg) Acknowledgment
Regarding Purchase of the Purchased Securities. HPPI acknowledges and agrees that Mayne Pharma is acting solely in the capacity of an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated
thereby. HPPI further acknowledges that Mayne Pharma is not acting as a financial advisor or fiduciary of HPPI (or in any similar capacity) with respect to the Transaction Documents and the transactions contemplated thereby and any advice given by
Mayne Pharma or any of its respective representatives or agents in connection with the Transaction Documents and the transactions contemplated thereby is merely incidental to Mayne Pharma’s purchase of the Purchased Securities. HPPI further
represents to Mayne Pharma that HPPI’s decision to enter into this Agreement and the other Transaction Documents has been based solely on the independent evaluation of the transactions contemplated hereby by HPPI and its representatives. 

  
 16 

 (hh) Regulation M Compliance. HPPI has not, and to its knowledge no one acting on
its behalf has, (i) taken, directly or indirectly, any action designed to cause or to result in the stabilization or manipulation of the price of any security of HPPI to facilitate the sale or resale of any of the Securities, (ii) sold,
bid for, purchased, or paid any compensation for soliciting purchases of, any of the Securities, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchase any other securities of HPPI. 

(ii) FDA. As to each product subject to the jurisdiction of the U.S. Food and Drug Administration (“FDA”) under the
Federal Food, Drug and Cosmetic Act, as amended, and the regulations thereunder (“FDCA”) that is manufactured, packaged, labeled, tested, distributed, sold, and/or marketed by HPPI or any of its Subsidiaries (each such product, a
“Pharmaceutical Product”), such Pharmaceutical Product is being manufactured, packaged, labeled, tested, distributed, sold and/or marketed by HPPI in compliance with all applicable requirements under FDCA and similar laws, rules and
regulations relating to registration, investigational use, premarket clearance, licensure, or application approval, good manufacturing practices, good laboratory practices, good clinical practices, product listing, quotas, labeling, advertising,
record keeping and filing of reports. There is no pending, completed or, to HPPI’s knowledge, threatened, Action against HPPI or any of its Subsidiaries, and none of HPPI or any of its Subsidiaries has received any notice, warning letter or
other communication from the FDA or any other Governmental Authority, which (i) contests the premarket clearance, licensure, registration, or approval of, the uses of, the distribution of, the manufacturing or packaging of, the testing of, the
sale of, or the labeling and promotion of any Pharmaceutical Product, (ii) withdraws its approval of, requests the recall, suspension, or seizure of, or withdraws or orders the withdrawal of advertising or sales promotional materials relating
to, any Pharmaceutical Product, (iii) imposes a clinical hold on any clinical investigation by HPPI or any of its Subsidiaries, (iv) enjoins production at any facility of HPPI or any of its Subsidiaries, (v) enters or proposes to
enter into a consent decree of permanent injunction with HPPI or any of its Subsidiaries, or (vi) otherwise alleges any violation of any laws, rules or regulations by HPPI or any of its Subsidiaries. The properties, business and operations of
HPPI have been and are being conducted in all material respects in accordance with all applicable laws, rules and regulations of the FDA. HPPI has not been informed by the FDA that the FDA will prohibit the marketing, sale, license or use in
the United States of any product proposed to be developed, produced or marketed by HPPI nor has the FDA expressed any concern as to approving or clearing for marketing any product being developed or proposed to be developed by HPPI. 

(jj) Office of Foreign Assets Control. Neither HPPI nor any Subsidiary nor, to HPPI’s knowledge, any director, officer, agent,
employee or Affiliate of HPPI or any Subsidiary is currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Treasury Department. 

(kk) U.S. Real Property Holding Corporation. HPPI is not and has never been a U.S. real property holding corporation within the
meaning of Section 897 of the Code, and HPPI shall so certify upon Mayne Pharma’s request. 
 (ll) Bank Holding Company
Act. Neither HPPI nor any of its Subsidiaries or Affiliates is subject to the Bank Holding Company Act of 1956, as amended (the “BHCA”) or to regulation by the Board of Governors of the Federal Reserve System (the
“Federal Reserve”). 

  
 17 

 
Neither HPPI nor any of its Subsidiaries or Affiliates owns or controls, directly or indirectly, five percent (5%) or more of the outstanding shares of any class of voting securities, or
twenty-five percent (25%) or more of the total equity, of a bank or any Person that is subject to the BHCA or to regulation by the Federal Reserve. Neither HPPI nor any of its Subsidiaries or Affiliates exercises a controlling influence over
the management or policies of a bank or any Person that is subject to the BHCA or to regulation by the Federal Reserve. 
 (mm) Money
Laundering. The operations of HPPI and its Subsidiaries are and have been conducted at all times in compliance with applicable financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as
amended, applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the “Money Laundering Laws”), and no Action by or before any Governmental Authority or any arbitrator involving HPPI or any
of its Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of HPPI or any Subsidiary, threatened. 
 (nn)
No Disqualification Events. With respect to the Securities to be offered and sold hereunder in reliance on Rule 506 under the Securities Act, none of HPPI, any of its predecessors, any Affiliated issuer, any director, executive officer, other
officer of HPPI participating in the offering hereunder, any beneficial owner of twenty percent (20%) or more of HPPI’s outstanding voting equity securities, calculated on the basis of voting power, nor any promoter (as that term is
defined in Rule 405 under the Securities Act) connected with HPPI in any capacity at the time of sale (each, an “Issuer Covered Person” and, together, “Issuer Covered Persons”) is subject to any of the “Bad
Actor” disqualifications described in Rule 506(d)(1)(i) through (viii) under the Securities Act (a “Disqualification Event”), except for a Disqualification Event covered by Rule 506(d)(2) or (d)(3). HPPI has exercised
reasonable care to determine whether any Issuer Covered Person is subject to a Disqualification Event. HPPI has complied, to the extent applicable, with its disclosure obligations under Rule 506(e), and has furnished to Mayne Pharma a copy of any
disclosures provided thereunder. 
 (oo) Other Covered Persons. HPPI is not aware of any Person (other than any Issuer Covered
Person) that has been or will be paid (directly or indirectly) remuneration for solicitation of purchasers in connection with the sale of any of the Securities. 

(pp) Notice of Disqualification Events. HPPI will notify Mayne Pharma in writing, prior to the Closing Date of (i) any
Disqualification Event relating to any Issuer Covered Person and (ii) any event that would, with the passage of time, become a Disqualification Event relating to any Issuer Covered Person. 

(qq) HPLLC Equity Investment. HPPI has provided to Mayne Pharma the substantial form of each document to be executed in connection
with the HPLLC Equity Investment. HPPI has made all necessary disclosures to HPLLC regarding this Agreement and the transactions contemplated hereby. 

Mayne Pharma acknowledges and agrees that the representations contained in Section 3.1 hereof shall not modify, amend or affect
HPPI’s right to rely on Mayne Pharma’s representations and warranties contained in this Agreement or any representations and warranties contained in any other Transaction Document or any other document or instrument executed and/or
delivered in connection with this Agreement or the consummation of the transaction contemplated hereby. 

  
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 3.2 Representations and Warranties of Mayne Pharma. Mayne Pharma hereby represents and
warrants to HPPI that each of the following representations and warranties is true and correct as of the Signing Date (except as otherwise indicated) and will be true and correct as of the Closing Date (except as otherwise indicated) 

(a) Organization; Authority. Mayne Pharma is a limited liability company duly organized, validly existing and in good standing under
the laws of the State of Delaware with full right, corporate power, and authority to enter into and to consummate the transactions contemplated by the Transaction Documents and otherwise to carry out its obligations hereunder and thereunder. The
execution, delivery and performance of the Transaction Documents and performance by Mayne Pharma of the transactions contemplated by the Transaction Documents have been duly authorized by all necessary corporate action on the part of Mayne Pharma.
Each Transaction Document to which it is a party has been duly executed by Mayne Pharma, and when delivered by Mayne Pharma in accordance with the terms hereof, will constitute the valid and legally binding obligation of Mayne Pharma, enforceable
against it in accordance with its terms. 
 (b) Own Account. Mayne Pharma understands that the Purchased Securities are
“restricted securities” and have not been registered under the Securities Act or any applicable state securities law and is acquiring the Purchased Securities as principal for its own account and not with a view to or for distributing or
reselling the Purchased Securities or any part thereof in violation of the Securities Act or any applicable state securities law, has no present intention of distributing the Purchased Securities in violation of the Securities Act or any applicable
state securities law and has no direct or indirect arrangement or understandings with any other Persons to distribute or regarding the distribution of the Purchased Securities in violation of the Securities Act or any applicable state securities law
(this representation and warranty not limiting Mayne Pharma’s right to sell the Purchased Securities in compliance with applicable federal and state securities laws). 

(c) Status of Mayne Pharma. At the time Mayne Pharma was offered the Purchased Securities, it was, and as of the date hereof it is,
and on each date on which it exercises the Make-Up Warrant or any part thereof or converts any of the Preferred Shares, it will be either: (i) an “accredited investor” as defined in Rule 501(a)(1), (a)(2), (a)(3), (a)(7) or (a)(8)
under the Securities Act or (ii) a “qualified institutional buyer” as defined in Rule 144A(a) under the Securities Act. 

(d) Experience of Mayne Pharma. Mayne Pharma, either alone or together with its representatives, has such knowledge, sophistication
and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Purchased Securities, and has so evaluated the merits and risks of such investment. Mayne Pharma understands
and acknowledges that: (i) an investment in HPPI is subject to substantial risk due to the nature of HPPI’s business and (ii) Mayne Pharma is able to bear the economic risk of an investment in the Purchased Securities and, at the
present time, is able to afford a complete loss of such investment. 

  
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 (e) No General Solicitation. Mayne Pharma is not purchasing the Purchased Securities as a
result of any advertisement, article, notice or other communication regarding the Purchased Securities published in any newspaper, magazine or similar media or broadcast over television, radio or the internet or presented at any seminar or any other
general solicitation or general advertisement. 
 (f) No Conflicts. The execution, delivery and performance by Mayne Pharma of this
Agreement and the other Transaction Documents to which it is a party and the consummation by Mayne Pharma of the transactions contemplated hereby and thereby do not and will not: (i) conflict with or violate any provision of Mayne Pharma’s
organizational or charter documents or (ii) subject to the Required Approvals, conflict with or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any Governmental Authority to which
Mayne Pharma or its Affiliates is subject (including federal and state securities laws and regulations), or by which any property or asset of Mayne Pharma or its Affiliates are bound or affected. 

(g) Disqualification Events. Neither Mayne Pharma nor any of its shareholders, members, managers, general or limited partners,
directors, Affiliates or executive officers, are subject to any Disqualification Event, except for a Disqualification Event covered by Rule 506(d)(2) or (d)(3). Mayne Pharma’s purchase of the Purchased Securities will not subject HPPI to any
Disqualification Event. 
 (h) Litigation. There is no Action, pending or, to the knowledge of Mayne Pharma or its Affiliates,
threatened against or affecting MPI, Mayne Pharma or any of their Affiliates or any of their respective properties which, individually or in the aggregate, (i) adversely affects or challenges the legality, validity or enforceability of any of
the Transaction Documents or the Purchased Securities or (ii) could, if there were an unfavorable decision, have or reasonably be expected to result in a Material Adverse Effect on MPI, Mayne Pharma or its Affiliates. 

HPPI acknowledges and agrees that the representations contained in Section 3.2 hereof shall not modify, amend or affect Mayne
Pharma’s right to rely on HPPI’s representations and warranties contained in this Agreement or any representations and warranties contained in any other Transaction Document or any other document or instrument executed and/or delivered in
connection with this Agreement or the consummation of the transaction contemplated hereby. 
 ARTICLE IV 

CONDITIONS TO CLOSING 

4.1 Conditions to Mayne Pharma’s Obligations at the Closing. The obligation of Mayne Pharma to consummate the Closing is subject
to the fulfillment (or waiver by Mayne Pharma) at or prior to the Closing of each of the following conditions: 
 (a) Representations
and Warranties. The representations and warranties of HPPI contained in Section 3.1 hereof shall be true and correct in all respects as of the Closing (other than representations and warranties that by their terms speak as of another
date, which representations and warranties shall be true and correct as of such date). 

  
 20 

 (b) Performance. HPPI shall have performed and complied with all covenants, agreements,
obligations, and conditions contained in this Agreement that are required to be performed or complied with by HPPI on or before the Closing. 

(c) Material Adverse Effect. Since the Signing Date, no fact, circumstance, event, change, occurrence, condition or development shall
have occurred that, individually or in the aggregate, has had or would be reasonably likely to have a Material Adverse Effect. 
 (d)
Compliance Certificate. The Chief Executive Officer and President of HPPI shall have duly executed and delivered to Mayne Pharma a certificate, dated as of the Closing Date, in form and substance satisfactory to Mayne Pharma, certifying to
the fulfillment of the conditions set forth in subsections (a), (b), (c), (e), (f), (n) and (o) of this Section 4.1. 

(e) Qualifications. All authorizations, approvals, or permits, if any, of any Governmental Authority that are required to be made or
obtained by HPPI in connection with the consummation of the transactions contemplated by this Agreement shall have been obtained and effective as of the Closing. 

(f) Litigation; Illegality. None of the transactions contemplated hereby shall have been enjoined by any Governmental Authority, no
Action challenging the transactions contemplated hereby shall have been threatened or instituted and no investigative or other demand shall have been made by any Governmental Authority, and no law shall have been enacted that prohibits, restrains,
or makes illegal the consummation of the transactions contemplated hereby. 
 (g) Equity Holders Agreement. HPPI and the other
respective parties thereto, other than Mayne Pharma, shall have duly executed and delivered to Mayne Pharma the Equity Holders Agreement, the substantial form of which is attached hereto as Annex C (the “Equity Holders
Agreement”). 
 (h) Legal Opinion. HPPI shall have delivered to Mayne Pharma a legal opinion, from HPPI’s Counsel,
dated as of the Closing Date, the substantial form of which shall be agreed to by HPPI’s Counsel and Mayne Pharma. 
 (i)
Secretary’s Certificate. HPPI shall have delivered to Mayne Pharma a certificate executed by the Secretary of HPPI, in form and substance satisfactory to Mayne Pharma, together with (i) a certified copy of HPPI’s amended and
restated certificate of incorporation in effect at the time of the Closing, (ii) HPPI’s bylaws in effect at the time of the Closing, (iii) certified resolutions of the Board of Directors authorizing the Transaction Documents and the
transaction contemplated thereby, (iv) a good standing certificate with respect to HPPI from the Secretary of State of the State of Delaware, dated a recent date before the Closing, and (v) a certification as to the incumbency of the
current officers of HPPI. 
 (j) [Intentionally Omitted]. 

(k) Employment Agreement. HPPI and Nicholas J. Virca (“Virca”) shall have entered into an employment agreement and a
confidentiality and intellectual property agreement, each in form and substance satisfactory to Mayne Pharma. In determining whether this condition is satisfied, the criteria set forth in Section 2 of Schedule 2 to the Supply Agreement shall
apply. 

  
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 (l) Executive Chairman Agreement. HPPI and Frank E. O’Donnell, Jr. shall have
entered into an executive chairman agreement and a confidentiality and intellectual property agreement, each in form and substance satisfactory to Mayne Pharma. In determining whether this condition is satisfied, the criteria set forth in
Section 2 of Schedule 2 to the Supply Agreement shall apply. 
 (m) Reservation of Shares. HPPI shall have duly authorized and
reserved for issuance the Conversion Shares and the Make-Up Warrant Shares. 
 (n) HPLLC Equity Investment. Other than the
consummation of the Purchase, all of the conditions to the consummation of the HPLLC Equity Investment shall have been fulfilled, and each party to the HPLLC Equity Investment shall have an obligation to consummate the HPLLC Equity Investment
immediately after the Closing. 
 (o) Debt Forgiveness Agreement. HPLLC and HPPI shall have executed a debt forgiveness agreement,
the form and substance of which shall be agreed upon by Mayne Pharma, pursuant to which the HPLLC Loans are forgiven, and the HPLLC Warrant, Seventy-One Thousand Six Hundred Thirty-Five and 981/1,000 (71,635.981) shares of Series A Preferred
Stock and Two Million Five Hundred Thirty Thousand Two Hundred Twenty-Seven (2,530,227) shares of Common Stock are issued. 
 (p)
Amended and Restated Supply Agreement. HPPI shall have duly executed and delivered to Mayne Pharma the Amended and Restated Supply Agreement the substantial form of which is attached hereto as Annex D (the “Amended Supply
Agreement”). 
 (q) Indemnification Agreement. HPPI and HPLLC shall have duly executed and delivered to Mayne Pharma the
Indemnification Agreement the substantial form of which is attached hereto as Annex E. 
 4.2 Conditions to HPPI’s
Obligations at the Closing. The obligation of HPPI to consummate the Closing is subject to the fulfillment (or waiver by HPPI) at or prior to the Closing of each of the following conditions: 

(a) Representations and Warranties. The representations and warranties of Mayne Pharma contained in Section 3.2 hereof
shall be true and correct in all respects as of the Closing (other than representations and warranties that by their terms speak as of another date, which representations and warranties shall be true and correct as of such date). 

(b) Performance. Mayne Pharma shall have performed and complied with all covenants, agreements, obligations, and conditions contained
in this Agreement that are required to be performed or complied with by Mayne Pharma on or before the Closing. 
 (c) Compliance
Certificate. An officer of Mayne Pharma shall have duly executed and delivered to HPPI a certificate, dated as of the Closing Date, in form and substance satisfactory to HPPI, certifying to the fulfillment of the conditions set forth in
subsections (a), (b) and (d) of this Section 4.2. 

  
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 (d) Qualifications. All authorizations, approvals, or permits, if any, of any
Governmental Authority that are required to be made or obtained by Mayne Pharma in connection with the consummation of the transactions contemplated by this Agreement shall have been obtained and effective as of the Closing. 

(e) Equity Holders Agreement. Mayne Pharma shall have duly executed and delivered to HPPI the Equity Holders Agreement. 

(f) HPLLC Equity Investment. Other than the consummation of the Purchase, all of the conditions to the consummation of the HPLLC
Equity Investment shall have been fulfilled, and each party to the HPLLC Equity Investment shall have an obligation to consummate the HPLLC Equity Investment immediately after the Closing. 

(g) Amended and Restated Supply Agreement. Mayne Pharma shall have duly executed and delivered to HPPI the Amended Supply Agreement.

 ARTICLE V 

COVENANTS 
 5.1
Commercially Reasonable Efforts. Subject to the terms and conditions of this Agreement, each of the parties will use its commercially reasonable efforts in good faith to take, or cause to be taken, all actions, and to do, or cause to be done,
all things necessary, proper or desirable, or advisable under applicable laws, so as to permit consummation of the Purchase as promptly as practicable and otherwise to enable consummation of the transactions contemplated hereby and shall use
commercially reasonable efforts to cooperate with the other party to that end. 
 5.2 Certain Notifications Until Closing. From the
Signing Date until the Closing Date, HPPI shall promptly notify Mayne Pharma of (i) any fact, event or circumstance of which HPPI is aware and which would be reasonably likely to cause any representation or warranty of HPPI contained in this
Agreement to be untrue or inaccurate in any material respect or to cause any covenant or agreement of HPPI contained in this Agreement not to be complied with or satisfied in any material respect and (ii) any fact, circumstance, event, change,
occurrence, condition or development of which HPPI is aware and which, individually or in the aggregate, has had or would be reasonably likely to have a Material Adverse Effect; provided, however, that delivery of any notice pursuant to this
Section 5.2 shall not limit or affect any rights of or remedies available to Mayne Pharma. 
 ARTICLE VI 

ADDITIONAL AGREEMENTS 

6.1 Transfer Restrictions. 

(a) Mayne Pharma acknowledges and agrees that the Securities may only be disposed of in compliance with state and federal securities laws. In
connection with any transfer 

  
 23 

 
of the Securities other than pursuant to an effective registration statement or Rule 144 or to HPPI or to an Affiliate of Mayne Pharma, HPPI may require the transferor thereof to provide to HPPI
an opinion of counsel selected by the transferor and reasonably acceptable to HPPI, the form and substance of which opinion shall be reasonably satisfactory to HPPI, to the effect that such transfer does not require registration of the Securities
which are transferred by the transferor under the Securities Act. As a condition of any such transfer, any such transferee shall agree in writing to be bound by the terms of this Agreement and shall have the rights and obligations of Mayne Pharma
under this Agreement. 
 (b) Mayne Pharma agrees to the imprinting, so long as is required by this Section 6.1, of a legend on
any of the Securities in the following form: 
 THIS SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE
SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED
BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. 

(c) Certificates evidencing the Preferred Shares, the Conversion Shares and the Make-Up Warrant Shares shall not be required to contain any
legend (including the legend set forth in Section 6.1(b) hereof): (i) while a registration statement covering the resale of such security is effective under the Securities Act or (ii) following or in connection with any sale of
the Preferred Shares, the Conversion Shares or the Make-Up Warrant Shares pursuant to Rule 144. HPPI shall cause (at HPPI’s cost) its counsel to issue a legal opinion to the Transfer Agent promptly after the occurrence of either of the
foregoing if required by the Transfer Agent to effect the removal of the legend hereunder. Certificates for Securities subject to legend removal hereunder shall upon Mayne Pharma’s request be transmitted by the Transfer Agent to Mayne Pharma by
crediting the account of Mayne Pharma’s prime broker with the Depository Trust Company System as directed by Mayne Pharma. 
 (d)
Mayne Pharma agrees with HPPI that Mayne Pharma will sell the Securities pursuant to either the registration requirements of the Securities Act, including any applicable prospectus delivery requirements, or an exemption therefrom, and that if any of
the Securities are sold pursuant to a registration statement, they will be sold in compliance with the plan of distribution set forth therein, and acknowledges that the removal of the restrictive legend from certificates representing the Securities
as set forth in this Section 6.1 is predicated upon HPPI’s reliance upon this understanding. 
 6.2 Integration.
HPPI shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that would be 

  
 24 

 
integrated with the offer or sale of any of the Securities in a manner that would require the registration under the Securities Act of the sale of any of the Securities or that would be
integrated with the offer or sale of any of the Securities for purposes of the rules and regulations of any Trading Market such that it would require shareholder approval prior to the closing of such other transaction unless shareholder approval is
obtained before the closing of such subsequent transaction. 
 (a) Securities Laws Disclosure; Publicity. HPPI shall (a) by
9:30 a.m. (New York City time) on the Trading Day immediately following the date hereof, issue a press release disclosing the material terms of the transactions contemplated hereby, and (b) file a Current Report on Form 8-K, including the
Transaction Documents as exhibits thereto, with the Commission within the time required by the Exchange Act. HPPI and Mayne Pharma shall consult with each other in issuing any other press releases with respect to the transactions contemplated
hereby, and neither HPPI nor Mayne Pharma shall issue any such press release nor otherwise make any such public statement without the prior consent of HPPI, with respect to any press release of Mayne Pharma, or without the prior consent of Mayne
Pharma, with respect to any press release of HPPI, which consent shall not unreasonably be withheld or delayed, except if such disclosure is required by law or any Trading Market, in which case the disclosing party shall promptly provide the other
party with prior notice of such public statement or communication. 
 (b) Shareholder Rights Plan. No claim will be made or enforced
by HPPI or, with the consent of HPPI, any other Person, that Mayne Pharma is an “acquiring person” under any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or similar
anti-takeover plan or arrangement in effect or hereafter adopted by HPPI, or that Mayne Pharma could be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving any of the Securities under the Transaction Documents or
under any other agreement between HPPI and Mayne Pharma. 
 6.3 Indemnification of Mayne Pharma, Etc. Subject to the provisions of
this Section 6.3, HPPI will indemnify and hold Mayne Pharma and Mayne Pharma’s directors, officers, shareholders, members, partners, employees and agents (and any other Person with a functionally equivalent role of a Person holding
such titles notwithstanding a lack of such title or any other title), each Person who controls (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act) Mayne Pharma, and the directors, officers,
shareholders, agents, members, partners or employees (and any other Person with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title) of such controlling Persons (each, a
“Mayne Pharma Party” and collectively, the “Mayne Pharma Parties”) harmless from and against any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments,
amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation that any Mayne Pharma Party may suffer or incur as a result of or relating to (a) any breach of any of the representations, warranties,
covenants or agreements made by HPPI in this Agreement or in any other Transaction Document or (b) any Action instituted against the Mayne Pharma Parties in any capacity, or any of them or their respective Affiliates with respect to any of the
transactions contemplated by the Transaction Documents (unless such Action is based upon a breach of such Mayne Pharma Party’s representations, warranties or covenants under the Transaction 

  
 25 

 
Documents or any violations by such Mayne Pharma Party of state or federal securities laws or any conduct by such Mayne Pharma Party which constitutes fraud, gross negligence, willful misconduct
or malfeasance). If any Action shall be brought against any Mayne Pharma Party in respect of which indemnity may be sought pursuant to this Agreement, such Mayne Pharma Party shall promptly notify HPPI in writing, and HPPI shall have the right to
assume the defense thereof with counsel of its own choosing reasonably acceptable to such Mayne Pharma Party. Any such Mayne Pharma Party shall have the right to employ separate counsel in any such Action and participate in the defense thereof, but
the fees and expenses of such counsel shall be at the expense of such Mayne Pharma Party except to the extent that (i) the employment thereof has been specifically authorized by HPPI in writing, (ii) HPPI has failed after a reasonable
period of time to assume such defense and to employ counsel or (iii) in such Action there is, in the reasonable opinion of counsel, a material conflict on any material issue between the position of HPPI and the position of such Mayne Pharma
Party, in which case HPPI shall be responsible for the reasonable fees and expenses of no more than one such separate counsel of such Mayne Pharma Party. HPPI will not be liable to any Mayne Pharma Party under this Agreement (y) for any
settlement by a Mayne Pharma Party effected without HPPI’s prior written consent, which shall not be unreasonably withheld or delayed; or (z) to the extent, but only to the extent that a loss, claim, damage or liability is attributable to
any Mayne Pharma Party’s breach of any of the representations, warranties, covenants or agreements made by such Mayne Pharma Party in this Agreement or in the other Transaction Documents. The indemnification required by this
Section 6.3 shall be made by periodic payments of the amount thereof during the course of the investigation or defense, as and when bills are received or are incurred. The indemnity agreements contained herein shall be in addition to any
cause of action or similar right of any Mayne Pharma Party against HPPI or others and any liabilities HPPI may be subject to pursuant to law 

6.4 Reservation of Common Stock. From the Closing Date until the date on which all of the Preferred Shares shall have been converted
and the Make-Up Warrant has been fully exercised, HPPI shall at all times have reserved for issuance, free of Liens, a sufficient number of shares of authorized and unissued Common Stock for the purpose of enabling HPPI to issue all of the
Conversion Shares and the Make-Up Warrant Shares. 
 6.5 Listing of Common Stock. HPPI agrees, if HPPI applies to have the Common
Stock traded on any Trading Market other than its current Trading Market, it will then include in such application all of the Conversion Shares and the Make-Up Warrant Shares, and will take such other action as is necessary to cause all of the
Conversion Shares and the Make-Up Warrant Shares to be listed or quoted on such other Trading Market as promptly as possible. For so long as the Common Stock trades or is listed for quotation on a Trading Market, HPPI agrees to use its commercially
reasonable efforts to maintain the eligibility of the Common Stock for electronic transfer through the Depository Trust Company or another established clearing corporation, including, without limitation, by timely payment of fees to the Depository
Trust Company or such other established clearing corporation in connection with such electronic transfer. 
 6.6 Certain Transactions and
Confidentiality. Mayne Pharma covenants that neither it, nor any Affiliate acting on its behalf or pursuant to any understanding with it will execute any purchases or sales of any of HPPI’s securities during the period commencing with the
Signing 

  
 26 

 
Date and ending at such time that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 6.2
hereof. Mayne Pharma covenants that until such time as the transactions contemplated by this Agreement are publicly disclosed by HPPI pursuant to the initial press release as described in Section 6.2 hereof, Mayne Pharma will maintain
the confidentiality of the existence and terms of this transaction and the information included in the Transaction Documents and the Disclosure Schedules. Notwithstanding the foregoing, and notwithstanding anything contained in this Agreement to the
contrary, HPPI expressly acknowledges and agrees that (i) Mayne Pharma makes no representation, warranty or covenant hereby that it will not engage in effecting transactions in any securities of HPPI after the time that the transactions
contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 6.2 hereof, (ii) Mayne Pharma shall not be restricted or prohibited from effecting any transactions in any
securities of HPPI in accordance with applicable securities laws from and after the time that the transactions contemplated by this Agreement are first publicly announced pursuant to the initial press release as described in Section 6.2
hereof, and (iii) Mayne Pharma shall have no duty of confidentiality to HPPI or its Subsidiaries after the issuance of the initial press release as described in Section 6.2 hereof. 

6.7 Acknowledgment of Dilution. HPPI acknowledges that the issuance of the Securities may result in dilution of the outstanding shares
of Common Stock, which dilution may be substantial under certain market conditions. HPPI further acknowledges that its obligations under the Transaction Documents, including, without limitation, its obligation to issue the Conversion Shares and
Make-Up Warrant Shares pursuant to the Transaction Documents, are unconditional and absolute and not subject to any right of set off, counterclaim, delay or reduction, regardless of the effect of any such dilution or any claim HPPI may have against
Mayne Pharma and regardless of the dilutive effect that such issuance may have on the ownership of the other stockholders of HPPI. 
 6.8
Equity Incentive Plan. HPPI covenants and agrees that, without the prior written consent of Mayne Pharma, the shares authorized to be purchased under the EIP shall not exceed 32,583,475 shares of Common Stock. 

6.9 HPLLC Equity Investment. HPPI shall close the HPLLC Equity Investment immediately after the Closing and shall not amend the terms
of the HPLLC Equity Investment in any respect. 
 6.10 Issuance of Make-Up Warrant. Immediately following the closing of the HPLLC
Equity Investment, HPPI shall issue to Mayne Pharma the Make-Up Warrant. 
 6.11 Registration Rights. HPPI agrees to provide to Mayne
Pharma the rights and privileges set forth in the Registration Rights Agreement, more specifically set forth in the form attached hereto as Annex F (the “Registration Rights Agreement”). Each of HPPI and Mayne Pharma agreed
to be bound by the Registration Rights Agreement. 
 6.12 Stock Certificate(s). Within three (3) Business Days after the Closing
Date, HPPI shall have delivered to Mayne Pharma, or its designee, stock certificate(s), registered in the name of Mayne Pharma, representing the Preferred Shares. 

  
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 ARTICLE VII 

MISCELLANEOUS 
 7.1
Termination. 
 (a) Notwithstanding anything in this Agreement to the contrary, this Agreement and the obligations of the parties
hereunder may be terminated on or prior to the Closing as follows: 
 (i) by HPPI or Mayne Pharma if the Closing shall not have taken place
within three (3) Business Days after the Signing Date or by such later date as shall be agreed upon by an appropriate amendment to this Agreement; provided that a party shall not have the right to terminate under this
Section 7.1(a)(i) if the conditions precedent to such party’s obligation to close have been fully satisfied and such party has failed or refused to close after being requested in writing to close by the other party; or 

(ii) by HPPI and Mayne Pharma upon their mutual written consent. 

(iii) In the event of the termination of this Agreement as provided in Section 7.1(a): 

(iv) this Agreement shall forthwith become void and there shall be no liability on the part of either party hereto, except that nothing
herein shall relieve either party from liability for any breach of this Agreement by such party; and 
 (v) the Supply Agreement shall
automatically terminate, without further action by any party hereto or thereto. 
 7.2 Fees and Expenses. Except as expressly set
forth in the Transaction Documents, each party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation, execution,
delivery and performance of this Agreement. HPPI shall pay all Transfer Agent fees (including, without limitation, any fees required for same-day processing of any instruction letter delivered by HPPI and any exercise notice delivered by Mayne
Pharma), stamp taxes and other taxes and duties levied in connection with the delivery of any of the Securities to Mayne Pharma. 
 7.3
Entire Agreement. This Agreement, together with the annexes, exhibits, and schedules hereto, and the other Transaction Documents, together with the annexes, exhibits and schedules thereto, contain the entire understanding of the parties with
respect to the subject matter hereof and thereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules. 

7.4 Notices. Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in
writing and shall be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered via facsimile at or prior to 5:30 p.m. (New York City time) on a Business Day, (b) the next
Business Day after the date of transmission, if such notice or communication is delivered via facsimile on 

  
 28 

 
a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Business Day, (c) the second (2nd) Business Day
following the date of mailing, if sent by U.S. nationally recognized overnight courier service or (d) upon actual receipt by the party to whom such notice is required to be given. All notices hereunder shall be delivered as set forth below, or
pursuant to such other instructions as may be designated in writing by the party to receive such notice. 
 If to Mayne Pharma: 

Mayne Pharma Ventures Pty Ltd 

Level 14, 474 Flinders Street 

Melbourne, Vic 3000 
 Australia

 Attention: General Counsel 

			
	Telephone:	 	61 3 8614 7711
	Facsimile:	 	61 3 9614 7022

 with a copy (which shall not constitute notice) to its counsel: 

Miller & Martin PLLC 

1180 West Peachtree Street, N.E., Suite 2100 

Atlanta, Georgia 30309 

Attention: A. Josef DeLisle, Esq. 

Facsimile: (404) 962-6338 

If to HPPI: 
 HedgePath
Pharmaceuticals, Inc. 
 324 Hyde Park Avenue #350 

Tampa, Florida 33606 

Attention: Nicholas Jon Virca 

Facsimile: (813) 258-6912 

with a copy (which shall not constitute notice) to its counsel: 

Ellenoff Grossman & Schole LLP 

1345 Avenue of the Americas, 11th Floor 

New York, New York 10105 

Attention: Barry I. Grossman, Esq. 

Facsimile: (212) 370-7889 

7.5 Amendments; Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument
signed, in the case of an amendment, by the duly authorized representatives of HPPI and Mayne Pharma or, in the case of a waiver, by the duly authorized representative of the party against whom enforcement of any such waived provision is sought. No
waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or
requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner impair the exercise of any such right. 

  
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 7.6 Headings. The headings herein are for convenience only, do not constitute a part of
this Agreement and shall not be deemed to limit or affect any of the provisions hereof. 
 7.7 Successors and Assigns. This Agreement
shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns. HPPI may not assign this Agreement or any rights or obligations hereunder without the prior written consent of Mayne Pharma. Mayne Pharma may
assign any or all of its rights under this Agreement to any Person to whom Mayne Pharma assigns or transfers any of the Securities, provided that such transferee agrees in writing to be bound, with respect to the transferred Securities, by the
provisions of the Transaction Documents that apply to “Mayne Pharma.” 
 7.8 No Third-Party Beneficiaries. This Agreement
is intended for the benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise set forth in
Section 6.3 hereof. 
 7.9 Governing Law. Each of the Transaction Documents and any dispute arising thereunder shall be
governed by and construed and enforced in accordance with the laws of the State of Delaware applicable to agreements made and to be performed wholly within such State, without regard to its conflict of law rules. 

7.10 Arbitration of Claims. In the event of any Action, question or disagreement arising from or relating to any Transaction Document
or the breach thereof, the parties hereto agree to settle such Action, question or disagreement by arbitration before a single arbitrator in Atlanta, Georgia, selected by, and such arbitration to be administered by, the American Arbitration
Association (“AAA”) in accordance with its International Arbitration Rules, and judgment on the award rendered by the arbitrator may be entered in any court having jurisdiction thereof. Each of the parties hereto agrees and
acknowledges that all Actions, questions or disagreements between or among them are subject to the alternative dispute resolution procedures of this Section 7.10. Each of the parties hereto agrees that any aspect of alternative dispute
resolution not specifically covered in this Agreement shall be covered, without limitation, by the applicable AAA rules and procedures. Each of the parties hereto further agrees that any determination by the arbitrator regarding any Action, question
or disagreement arising from or relating to this Agreement shall be final and binding upon the parties hereto and shall not be subject to further appeal. 

7.11 Survival. The representations, warranties and covenants contained herein shall survive the Closing and the delivery of the
Purchased Securities. 
 7.12 Execution. This Agreement may be executed in two or more counterparts, all of which when taken together
shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being understood that the parties need not sign the same counterpart. In the event that
any signature is delivered by facsimile transmission or by e-mail delivery of a “.pdf” format data file, 

  
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such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or
“.pdf” signature page were an original thereof. 
 7.13 Severability. If any term, provision, covenant or restriction of
this Agreement or any of the Transaction Documents is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full
force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that
contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed the remaining terms, provisions, covenants and restrictions without including any of
such that may be hereafter declared invalid, illegal, void or unenforceable. 
 7.14 Rescission and Withdrawal Right. Notwithstanding
anything to the contrary contained in (and without limiting any similar provisions of) any of the other Transaction Documents, whenever Mayne Pharma exercises a right, election, demand or option under a Transaction Document and HPPI does not timely
perform its related obligations within the periods therein provided, then Mayne Pharma may rescind or withdraw, in its sole discretion from time to time upon written notice to HPPI, any relevant notice, demand or election in whole or in part without
prejudice to its future actions and rights; provided, however, that in the case of a rescission of an exercise of the Make-Up Warrant or any part thereof, Mayne Pharma shall be required to return any shares of Common Stock subject to any such
rescinded exercise notice concurrently with the return to Mayne Pharma of the aggregate exercise price paid to HPPI for such shares and the restoration of Mayne Pharma’s right to acquire such shares pursuant to the Make-Up Warrant (including,
issuance of a replacement warrant certificate evidencing such restored right). 
 7.15 Replacement of Securities. If any certificate
or instrument evidencing any of the Securities is mutilated, lost, stolen or destroyed, HPPI shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof (in the case of mutilation), or in lieu of and substitution
therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to HPPI of such loss, theft or destruction. The applicant for a new certificate or instrument under such circumstances shall also pay any reasonable
third-party costs (including customary indemnity) associated with the issuance of such replacement securities. 
 7.16 Remedies. In
addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of Mayne Pharma and HPPI will be entitled to specific performance under the Transaction Documents. The parties agree that
monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents and hereby agree to waive and not to assert in any action for specific performance of any such
obligation the defense that a remedy at law would be adequate. 
 7.17 Payment Set Aside. To the extent that HPPI makes a payment or
payments to Mayne Pharma pursuant to any Transaction Document or Mayne Pharma enforces or exercises 

  
 31 

 
its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential,
set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to HPPI, a trustee, receiver or any other Person under any law (including, without limitation, any bankruptcy law, state or federal law, common law
or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such
enforcement or setoff had not occurred. 
 7.18 Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any
action or the expiration of any right required or granted herein shall not be a Business Day, then such action may be taken or such right may be exercised on the next succeeding Business Day. 

7.19 Construction. The parties agree that each of them and/or their respective counsel have reviewed and had an opportunity to revise
the Transaction Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of the Transaction Documents or any amendments
thereto. In addition, each and every reference to shares of Common Stock in any Transaction Document shall be subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations and other similar transactions of the
Common Stock that occur after the date of this Agreement. When a reference is made in this Agreement to “Recitals”, “Articles”, “Sections” or “Annexes”, such reference shall be to a Recital, Article or Section
of, or Annex to, this Agreement unless otherwise indicated. The terms defined in the singular have a comparable meaning when used in the plural, and vice versa. References to “herein”, “hereof”, “hereunder” and the like
refer to this Agreement as a whole and not to any particular section or provision, unless the context requires otherwise. All references to “$” or “dollars” mean the lawful currency of the United States of America. Except as
expressly stated in this Agreement, all references to any statute, rule or regulation are to the statute, rule or regulation as amended, modified, supplemented or replaced from time to time (and, in the case of statutes, include any rules and
regulations promulgated under the statute) and to any section of any statute, rule or regulation include any successor to the section. 

7.20 WAIVER OF JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT BY ANY PARTY AGAINST ANY OTHER PARTY, THE
PARTIES EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, HEREBY ABSOLUTELY, UNCONDITIONALLY, IRREVOCABLY AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY. 

[Remainder of page intentionally left blank. 

Signature page immediately follows.] 

  
 32 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by
their respective authorized signatories as of the date first indicated above. 
  

			
	HEDGEPATH PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Nicholas J. Virca

	Name:	 	 Nicholas J. Virca

	Title:	 	 President and Chief Executive Officer

	
	MAYNE PHARMA VENTURES PTY LTD
		
	By:	 	 /s/ Scott A. Richards

	Name:	 	 Scott A. Richards

	Title:	 	 Director

 Signature Page to Securities Purchase Agreement

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