Document:

<PAGE>

                                                                   EXHIBIT 10.45

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A
VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE
OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT
RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY
THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.

                            SECURED PROMISSORY NOTE
                            -----------------------

((Principal Amount))                                                   ((Date))
                                                          Emeryville,California

     For value received, HealthCentral.com, a Delaware corporation (the
"Company"), promises to pay to [[Purchaser]] (the "Holder"), the principal sum
 -------                                        ------
of [[Amount]] Dollars ([[Principal Amount]]). Interest shall accrue from the
date of this Note on the unpaid principal amount at a rate equal percent (8.5%)
per annum, simple interest. This Note is one of a series of Secured Promissory
Notes containing substantially identical terms and conditions issued pursuant to
that certain Secured Promissory Note and Warrant Purchase Agreement of even date
herewith (the "Purchase Agreement"). Such Notes are referred to herein as the
               ------------------
"Notes," and the holders thereof are referred to herein as the "Holders."  This
------                                                          -------
Note is subject to the following terms and conditions.  Capitalized terms used
herein, but not defined herein, shall have those meanings ascribed to them in
the Purchase Agreement.

     1.   Maturity.  This Note will automatically mature and be due and payable
          --------
on December 31, 2003 (the "Maturity Date"). Interest shall accrue on the
                           -------------
outstanding balance under this Note beginning on the date hereof, and accrued
interest shall be due and payable monthly in arrears during the term of Note.
Notwithstanding the foregoing, the entire unpaid principal sum of this Note,
together with accrued and unpaid interest thereon, shall become immediately due
and payable upon the insolvency of the Company, the commission of any act of
bankruptcy by the Company, the execution by the Company of a general assignment
for the benefit of creditors, the filing by or against the Company of a petition
in bankruptcy or any petition for relief under the federal bankruptcy act or the
continuation of such petition without dismissal for a period of ninety (90) days
or more, or the appointment of a receiver or trustee to take possession of the
property or assets of the Company.

     2.   Payment.  All payments shall be made in lawful money of the United
          -------
States of America at such place as the Holder hereof may from time to time
designate in

                                       1
<PAGE>

writing to the Company. Payment shall be credited first to the accrued interest
then due and payable, and the remainder applied to principal. Prepayment of this
Note may be made at any time without penalty, provided that all of the Notes
shall be prepaid on a pro rata basis.

     3.   Transfer; Successors and Assigns.  The terms and conditions of this
          --------------------------------
Note shall inure to the benefit of and be binding upon the respective successors
and assigns of the parties. Notwithstanding the foregoing, the Holder may not
assign, pledge, or otherwise transfer this Note without the prior written
consent of the Company, except for transfers to affiliates. Subject to the
preceding sentence, this Note may be transferred only upon surrender of the
original Note for registration of transfer, duly endorsed, or accompanied by a
duly executed written instrument of transfer in form satisfactory to the
Company. Thereupon, a new note for the same principal amount and interest will
be issued to, and registered in the name of, the transferee, subject to the
transferee's execution of an agreement to be bound by all provisions of this
Note and the other Transaction Documents applicable to the transferor, including
but not limited to the agreement to subordinate this Note in certain
circumstances upon the approval of the Holders of all of the principal
outstanding under the Notes, pursuant to the Purchase Agreement. Interest and
principal are payable only to the registered holder of this Note.

     4.   Governing Law.  This Note and all acts and transactions pursuant
          -------------
hereto and the rights and obligations of the parties hereto shall be governed,
construed and interpreted in accordance with the laws of the State of
California, without giving effect to principles of conflicts of law.

     5.   Notices.  Any notice required or permitted by this Note shall be in
          -------
writing and shall be deemed sufficient upon delivery, when delivered personally
or by a nationally-recognized delivery service (such as Federal Express or UPS),
or forty-eight (48) hours after being deposited in the U.S. mail, as certified
or registered mail, with postage prepaid, addressed to the party to be notified
at such party's address as set forth below or as subsequently modified by
written notice.

     6.   Amendments and Waivers.  Any term of this Note may be amended only
          ----------------------
with the written consent of the Company and the Holders of all of the
outstanding Notes.  Any amendment or waiver effected in accordance with this
Section 6 shall be binding upon the Company, the Holders and each transferee of
the Notes.

     7.   Stockholders, Officers and Directors Not Liable.  In no event shall
          -----------------------------------------------
any stockholder, officer or director of the Company be liable for any amounts
due or payable pursuant to this Note.

     8.   Security Interest.  This Note is secured by all of the inventory and
          -----------------
accounts receivable of the Company in accordance with a separate security
agreement (the "Security Agreement") of even date herewith between the Company
                ------------------
and the Holder. In case of an Event of Default (as defined in the Security
Agreement), the Holder shall have the rights set forth in the Security
Agreement.

                                      -2-
<PAGE>

     9.   Action to Collect on Note.  If action is instituted to collect on this
          -------------------------
Note, the Company promises to pay all costs and expenses, including reasonable
attorney's fees, incurred in connection with such action.

                                        COMPANY:

                                        HEALTHCENTRAL.COM

                                        By: ____________________________________

                                        Name: __________________________________
                                                             (print)
                                        Title: _________________________________

                                        Address:  6005 Shellmound St., Suite 250
                                                  Emeryville, CA 94608

AGREED TO AND ACCEPTED:

((PURCHASER))

By: ______________________________

Name: ____________________________
           (print)
Title:  __________________________

Address:
((Address1))
((Address2))

                                      -3-<PAGE>

                                                                   EXHIBIT 10.46

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A
VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE
OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT
RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY
THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.
--------------------------------------------------------------------------------

Warrant No. ((WarrantNo))                        Number of Shares:  ((NoShares))
Date of Issuance:  ((Date))                      (subject to adjustment)

                               HEALTHCENTRAL.COM

                             Common Stock Warrant
                             --------------------

     HealthCentral.com (the "Company"), for value received, hereby certifies
                             -------
that ((Holder)), or its registered assigns (the "Registered Holder"), is
                                                 -----------------

entitled, subject to the terms set forth below, to purchase from the Company, at
any time after the date hereof and on or before the Expiration Date (as defined
in Section 5 below), up to NoShares~ shares (as adjusted from time to time
pursuant to the provisions of this Warrant) of Common Stock of the Company, at a
per share purchase price equal to the average closing sale price for the twenty
(20) trading days prior to the date of this Warrant, as reported by Nasdaq. The
shares purchasable upon exercise of this Warrant and the purchase price per
share, as adjusted from time to time pursuant to the provisions of this Warrant,
are hereinafter referred to as the "Warrant Stock" and the "Purchase Price,"
                                    -------------           --------------
respectively.

     This Warrant is issued pursuant to a Note and Warrant Purchase Agreement of
even date herewith by and among the Company and each of the Purchasers (as
defined therein) (the "Purchase Agreement") and is subject to the terms and
                       ------------------
conditions of the Purchase Agreement.

     1.   Exercise.
          --------

          (a) Manner of Exercise.  This Warrant may be exercised by the
              ------------------
Registered Holder, in whole or in part, by surrendering this Warrant, with the
purchase/exercise form appended hereto as Exhibit A duly executed by such
                                          ---------
Registered Holder or by such Registered Holder's duly authorized attorney, at
the principal office of the Company, or at such other office or agency as the
Company may designate, accompanied by payment in full of the Purchase Price
payable in respect of the number of shares of Warrant Stock purchased upon such
exercise. The Purchase Price may be paid by cash, check, wire transfer or by the
surrender of promissory notes or other instruments representing indebtedness of
the Company to the Registered Holder.

          (b) Effective Time of Exercise. Each exercise of this Warrant shall
              --------------------------
be deemed to have been effected immediately prior to the close of business on
the day on which this Warrant shall have been surrendered to the Company as
provided in Section 1(a) above. At such
<PAGE>

time, the person or persons in whose name or names any certificates for Warrant
Stock shall be issuable upon such exercise as provided in Section 1(c) below
shall be deemed to have become the holder or holders of record of the Warrant
Stock represented by such certificates.

          (c)  Net Issue Exercise.
               ------------------

               (i) In lieu of exercising this Warrant in the manner provided
above in Section 1(a), the Registered Holder may elect to receive shares equal
to the value of this Warrant (or the portion thereof being canceled) by
surrender of this Warrant at the principal office of the Company together with
notice of such election on the purchase/exercise form appended hereto as Exhibit
                                                                         -------
A duly executed by such Registered Holder or such Registered Holder's duly
-
authorized attorney, in which event the Company shall issue to holder a number
of shares of Common Stock computed using the following formula:

                    X =  Y (A - B)
                         ---------

                             A

Where     X =  The number of shares of Common Stock to be issued to the
               Registered Holder.

          Y =  The number of shares of Common Stock purchasable under this
               Warrant (at the date of such calculation).

          A =  The fair market value of one share of Common Stock (at the date
               of such calculation).

          B =  The Purchase Price (as adjusted to the date of such calculation).

                    (ii) For purposes of this Section 1(c), the fair market
value of one share of Common Stock on the date of calculation shall mean:

                         (A) if the Company's Common Stock is traded on a
securities exchange or The Nasdaq Stock Market, the fair market value shall be
deemed to be the average of the closing prices over the twenty (20) trading days
ending the day before date of calculation; or

                         (B) if the Company's Common Stock is actively traded
over-the-counter, the fair market value shall be deemed to be the average of the
closing bid or sales price (whichever is applicable) over the twenty (20)
trading days ending the day before the date of calculation; or

                         (C) if neither (A) nor (B) is applicable, the fair
market value shall be at the highest price per share which the Company could
obtain on the date of calculation from a willing buyer (not a current employee
or director) for shares of Common Stock sold by the Company, from authorized but
unissued shares, as determined in good faith by the Board of Directors.
<PAGE>

          (d) Delivery to Holder.  As soon as practicable after the exercise of
              ------------------
this Warrant in whole or in part, and in any event within ten (10) days
thereafter, the Company at its expense will cause to be issued in the name of,
and delivered to, the Registered Holder, or as such Holder (upon payment by such
Holder of any applicable transfer taxes) may direct:

              (i)  a certificate or certificates for the number of shares of
Warrant Stock to which such Registered Holder shall be entitled, and

              (ii) in case such exercise is in part only, a new warrant or
warrants (dated the date hereof) of like tenor, calling in the aggregate on the
face or faces thereof for the number of shares of Warrant Stock equal (without
giving effect to any adjustment therein) to the number of such shares called for
on the face of this Warrant minus the number of such shares purchased by the
Registered Holder upon such exercise as provided in Section 1(a) above.

     2.   Adjustments.
          -----------

          (a) Stock Splits and Dividends. If outstanding shares of the Company's
              --------------------------
Common Stock shall be subdivided into a greater number of shares or a dividend
in Common Stock shall be paid in respect of Common Stock, the Purchase Price in
effect immediately prior to such subdivision or at the record date of such
dividend shall simultaneously with the effectiveness of such subdivision or
immediately after the record date of such dividend be proportionately reduced.
If outstanding shares of Common Stock shall be combined into a smaller number of
shares, the Purchase Price in effect immediately prior to such combination
shall, simultaneously with the effectiveness of such combination, be
proportionately increased. When any adjustment is required to be made in the
Purchase Price, the number of shares of Warrant Stock purchasable upon the
exercise of this Warrant shall be changed to the number determined by dividing
(i) an amount equal to the number of shares issuable upon the exercise of this
Warrant immediately prior to such adjustment, multiplied by the Purchase Price
in effect immediately prior to such adjustment, by (ii) the Purchase Price in
effect immediately after such adjustment.

          (b) Reclassification, Etc.  In case of any reclassification or change
              ----------------------
of the outstanding securities of the Company or of any reorganization of the
Company (or any other corporation the stock or securities of which are at the
time receivable upon the exercise of this Warrant) or any similar corporate
reorganization on or after the date hereof, then and in each such case the
holder of this Warrant, upon the exercise hereof at any time after the
consummation of such reclassification, change or reorganization shall be
entitled to receive, in lieu of the stock or other securities and property
receivable upon the exercise hereof prior to such consummation, the stock or
other securities or property to which such holder would have been entitled upon
such consummation if such holder had exercised this Warrant immediately prior
thereto, all subject to further adjustment as provided in Section 2(a); and in
each such case, the terms of this Section 2 shall be applicable to the shares of
stock or other securities properly receivable upon the exercise of this Warrant
after such consummation.

          (c) Adjustment Certificate.  When any adjustment is required to be
              ----------------------
made in the Warrant Stock or the Purchase Price pursuant to this Section 2, the
Company shall promptly mail to the Registered Holder a certificate setting forth
(i) a brief statement of the facts requiring
<PAGE>

such adjustment, (ii) the Purchase Price after such adjustment and (iii) the
kind and amount of stock or other securities or property into which this Warrant
shall be exercisable after such adjustment.

     3.   Transfers.
          ---------

          (a) Unregistered Security.  Each holder of this Warrant acknowledges
              ---------------------
that this Warrant and the Warrant Stock have not been registered under the
Securities Act of 1933, as amended (the "Securities Act"), and agrees not to
                                         --------------
sell, pledge, distribute, offer for sale, transfer or otherwise dispose of this
Warrant or any Warrant Stock issued upon its exercise in the absence of (i) an
effective registration statement under the Act as to this Warrant or such
Warrant Stock and registration or qualification of this Warrant or such Warrant
Stock under any applicable U.S. federal or state securities law then in effect
or (ii) an opinion of counsel, reasonably satisfactory to the Company, that such
registration and qualification are not required. Each certificate or other
instrument for Warrant Stock issued upon the exercise of this Warrant shall bear
a legend substantially to the foregoing effect.

          (b) Transferability.  Subject to the provisions of Section 3(a)
              ---------------
hereof, this Warrant and all rights hereunder are transferable, in whole or in
part, upon surrender of the Warrant with a properly executed assignment (in the
form of Exhibit B hereto) at the principal office of the Company provided,
        ---------                                                --------
however, that this Warrant may not be transferred in part unless the transferee
-------
acquires the right to purchase at least 100,000 shares (as adjusted pursuant to
Section 2) of Warrant Stock hereunder.

          (c) Warrant Register.  The Company will maintain a register containing
              ----------------
the names and addresses of the Registered Holders of this Warrant. Until any
transfer of this Warrant is made in the warrant register, the Company may treat
the Registered Holder of this Warrant as the absolute owner hereof for all
purposes; provided, however, that if this Warrant is properly assigned in blank,
          --------  -------
the Company may (but shall not be required to) treat the bearer hereof as the
absolute owner hereof for all purposes, notwithstanding any notice to the
contrary. Any Registered Holder may change such Registered Holder's address as
shown on the warrant register by written notice to the Company requesting such
change.

     4.   No Impairment. The Company will not, by amendment of its charter or
          -------------
through reorganization, consolidation, merger, dissolution, sale of assets or
any other voluntary action, avoid or seek to avoid the observance or performance
of any of the terms of this Warrant, but will (subject to Section 13 below) at
all times in good faith assist in the carrying out of all such terms and in the
taking of all such action as may be necessary or appropriate in order to protect
the rights of the holder of this Warrant against impairment.

     5.   Termination.  This Warrant (and the right to purchase securities upon
          -----------
exercise hereof) shall terminate on the fifth anniversary of the date of this
Warrant (the "Expiration Date").
              ---------------

     6.   Notices of Certain Transactions.  In case:
          -------------------------------

          (a) the Company shall take a record of the holders of its Common Stock
(or other stock or securities at the time deliverable upon the exercise of this
Warrant) for the purpose
<PAGE>

of entitling or enabling them to receive any dividend or other distribution, or
to receive any right to subscribe for or purchase any shares of stock of any
class or any other securities, or to receive any other right, to subscribe for
or purchase any shares of stock of any class or any other securities, or to
receive any other right, or

          (b) of any capital reorganization of the Company, any reclassification
of the capital stock of the Company, any consolidation or merger of the Company,
any consolidation or merger of the Company with or into another corporation
(other than a consolidation or merger in which the Company is the surviving
entity), or any transfer of all or substantially all of the assets of the
Company, or

          (c) of the voluntary or involuntary dissolution, liquidation or
winding-up of the Company,

then, and in each such case, the Company will mail or cause to be mailed to the
Registered Holder of this Warrant a notice specifying, as the case may be, (i)
the date on which a record is to be taken for the purpose of such dividend,
distribution or right, and stating the amount and character of such dividend,
distribution or right, or (ii) the effective date on which such reorganization,
reclassification, consolidation, merger, transfer, dissolution, liquidation or
winding-up is to take place, and the time, if any is to be fixed, as of which
the holders of record of Common Stock (or such other stock or securities at the
time deliverable upon such reorganization, reclassification, consolidation,
merger, transfer, dissolution, liquidation or winding-up) are to be determined.

     7.   Reservation of Stock.  The Company will at all times reserve and keep
          --------------------
available, solely for the issuance and delivery upon the exercise of this
Warrant, such shares of Warrant Stock and other stock, securities and property,
as from time to time shall be issuable upon the exercise of this Warrant.

     8.   Exchange of Warrants.  Upon the surrender by the Registered Holder of
          --------------------
any Warrant or Warrants, properly endorsed, to the Company at the principal
office of the Company, the Company will, subject to the provisions of Section 3
hereof, issue and deliver to or upon the order of such Holder, at the Company's
expense, a new Warrant or Warrants of like tenor, in the name of such Registered
Holder or as such Registered Holder (upon payment by such Registered Holder of
any applicable transfer taxes) may direct, calling in the aggregate on the face
or faces thereof for the number of shares of Common Stock called for on the face
or faces of the Warrant or Warrants so surrendered.

     9.   Replacement of Warrants.  Upon receipt of evidence reasonably
          -----------------------
satisfactory to the Company of the loss, theft, destruction or mutilation of
this Warrant and (in the case of loss, theft or destruction) upon delivery of an
indemnity agreement (with surety if reasonably required) in an amount reasonably
satisfactory to the Company, or (in the case of mutilation) upon surrender and
cancellation of this Warrant, the Company will issue, in lieu thereof, a new
Warrant of like tenor.

     10.  Notices.  Any notice required or permitted by this Warrant shall be in
          -------
writing and shall be deemed sufficient upon receipt, when delivered personally
or by courier, overnight
<PAGE>

delivery service or confirmed facsimile, or forty-eight (48) hours after being
deposited in the regular mail as certified or registered mail (airmail if sent
internationally) with postage prepaid, addressed (a) if to the Registered
Holder, to the address of the Registered Holder most recently furnished in
writing to the Company and (b) if to the Company, to the address set forth below
or subsequently modified by written notice to the Registered Holder.

     11.  No Rights as Shareholder.  Until the exercise of this Warrant, the
          ------------------------
Registered Holder of this Warrant shall not have or exercise any rights by
virtue hereof as a shareholder of the Company.

     12.  No Fractional Shares.  No fractional shares of Common Stock will be
          --------------------
issued in connection with any exercise hereunder. In lieu of any fractional
shares which would otherwise be issuable, the Company shall pay cash equal to
the product of such fraction multiplied by the fair market value of one share of
Common Stock on the date of exercise, as determined in good faith by the
Company's Board of Directors.

     13.  Amendment or Waiver.  Any term of this Warrant may be amended or
          -------------------
waived upon written consent of the Company and the holders of all of the shares
of Common Stock issuable upon exercise of outstanding warrants purchased
pursuant to the Purchase Agreement.

     14.  Headings.  The headings in this Warrant are for purposes of reference
          --------
only and shall not limit or otherwise affect the meaning of any provision of
this Warrant.

     15.  Governing Law.  This Warrant shall be governed, construed and
          -------------
interpreted in accordance with the laws of the State of California, without
giving effect to principles of conflicts of law.
<PAGE>

     16.  Registration Rights.  The Warrant Shares are subject to the re-sale
          -------------------
registration rights described in the Registration Rights Agreement by and among
the Company and the Purchasers and dated concurrently herewith.

                                        HEALTHCENTRAL.COM

                                        By _____________________________________

                                        Name: __________________________________
                                                             (print)
                                        Title: _________________________________

                                        Address:  6005 Shellmound St., Suite 250
                                                  Emeryville, CA 94608

                                        Fax Number:  510-250-2703

                    SIGNATURE PAGE TO COMMON STOCK WARRANT
<PAGE>

                                   EXHIBIT A
                                   ---------
                            PURCHASE/EXERCISE FORM
                            ----------------------

To:  HealthCentral.com                        Dated:

     The undersigned, pursuant to the provisions set forth in the attached
Warrant No. ((WarrantNo)), hereby irrevocably elects to (a) purchase _______
shares of the Common Stock covered by such Warrant and herewith makes payment of
$_________, representing the full purchase price for such shares at the price
per share provided for in such Warrant, or (b) exercise such Warrant for _______
shares purchasable under the Warrant pursuant to the Net Issue Exercise
provisions of Section 1(c) of such Warrant.

     The undersigned acknowledges that it has reviewed the representations and
warranties contained in Section 2 of the Purchase Agreement (as defined in the
Warrant) and by its signature below hereby makes such representations and
warranties to the Company. Defined terms contained in such representations and
warranties shall have the meanings assigned to them in the Purchase Agreement,
provided that the term "Purchaser" shall refer to the undersigned and the term
--------
"Securities" shall refer to the Warrant Stock.

                                             Signature: ________________________

                                             Name (print): _____________________

                                             Title (if applic.): _______________

                                             Company (if applic.): _____________
<PAGE>

                                   EXHIBIT B
                                   ---------

                                ASSIGNMENT FORM
                                ---------------

     FOR VALUE RECEIVED, _________________________________________ hereby sells,
assigns and transfers all of the rights of the undersigned under the attached
Warrant with respect to the number of shares of Common Stock covered thereby set
forth below, unto:

        Name of Assignee         Address/Fax Number           No. of Shares
        ----------------         ------------------           -------------

Dated: ______________________________    Signature: ___________________________

                                                    ___________________________

                                         Witness:   ___________________________

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