Document:

Exhibit 10.10

 

AMENDED AND RESTATED

BUSINESS COOPERATION AGREEMENT

 

This Amended and Restated Business Cooperation Agreement
is dated as of January 16, 2022, and effective as of December 31, 2021 (the “Effective Date”) by and between Kosmik
Development Skopje doo, a Macedonian foreign-owned corporation with offices located at 23 Oktomvri, 11A Synergy Business Center,
Skopje 1000 Macedonia (the “Executor”) and Rumble Inc., a corporation incorporated under the laws of the Province
of Ontario with offices ‎located at 218 Adelaide Street West, Suite 400, Toronto, ON M5H 1W7 (the “Customer”).

 

The Executor and the Customer may be referred to
herein individually as a “Party” or collectively as the “Parties”.

 

WHEREAS the Parties entered into a business
cooperation agreement dated as of February 1, 2016 (the “Original Agreement”);

 

AND WHEREAS the Original Agreement was subsequently
amended by the Parties through the entering into of an addendum to the Original Agreement dated as of January 1, 2021(the “Addendum”)
(the Original Agreement as amended by the Addendum being referred to herein as the “Existing Agreement”);

 

AND WHEREAS the Parties wish to amend and
restate the Existing Agreement for the purposes and on the terms and conditions set forth in this Agreement;

 

NOW THEREFORE, IN CONSIDERATION of the
covenants, agreements and promises set forth herein and for other good and valuable consideration, the receipt and sufficiency of which
is hereby acknowledged, the Parties agree as follows:

 

		1.	INTERPRETATION

 

As used in this Agreement, the following terms
shall have the following meanings unless the context otherwise requires:

 

“Canadian Arbitration Association”
means the alternative dispute resolution group called “Canadian Arbitration Association” that provides arbitration services
in Canada, with current address at 180 Duncan Mill Road, 4th Floor, Toronto, Ontario, Canada M3B 1Z6.

 

‎“Commercial Arbitration Rules”
means the commercial arbitration rules of the ‎Canadian Arbitration Association in effect from time to time. ‎

 

“Cost(s)” means, in respect
of any applicable period, all of the costs reasonably incurred by the Executor in performing services for the Customer pursuant to this
Agreement for such period, including but not limited to, capital expenditures, employee costs, overhead, lease costs, and supplies, but
excluding any salary or other compensatory payments made to any Board member or executive of the Customer or any of their respective affiliates
or family members.

 

     

     

    

 

“Customer IT Network”
means the information network of Customer used to deliver information to its personnel, users and to third parties dealing with its information
and includes all computer hardware, all telecommunication systems (together with wiring infrastructure) and all software utilized in relation
thereto, including system software, utility software, firmware and all other software whether the same is proprietary, leased or licensed
to Customer;

 

“Intellectual Property” means
all means all (a) patents, patent applications, priority patent filings, including any and all divisionals, continuations (in whole
or in part), requests for continued examination, reissues, reexaminations, additions, substitution cases, confirmations, registrations,
revalidations, revisions, renewals and extensions thereof, (b) trademarks, service marks, domain names, trade dress, logos, trade
names and other indicia of origin, including registrations and applications for registration thereof, (c) copyrights and registrations
and applications for registration thereof, (d) computer software, data, databases and documentation related thereto, (e) trade
secrets and confidential business information, and inventions whether patentable or unpatentable and whether or not reduced to practice,
know-how, research and development information and copyrightable works, (f) Moral Rights (as defined in Section 10 herein), (g) all other
intellectual property or proprietary rights, and (h) copies and tangible embodiments of any of the foregoing.

 

“Malicious Code”
means: (i) any code instructions, data or functions (including but not limited to viruses, worms, Trojan horses, data bombs, or time bombs),
the purpose of which is to maliciously cause the said technology to cease operating, or to damage, interrupt, interfere with or hinder
the operation of Customer’s IT Network or other computer systems, the system in which it resides, or any other software or data
on such system; (ii) any intentionally hidden or embedded elements that would cause the software or other technology to become unstable
or disabled upon conditions outside of the knowledge or control of Customer, and the software or other technology does not contain any
locks dependent upon either software or hardware which Customer has not been fully apprised of, and where required provided with, any
enabling hard or soft key; or (iii) any programming designed to collect information about users, or to store or transmit information,
whether Confidential Information or not, about Customer to Executor or a third party, other than programming whose data collection, storage
or transmission functionality, as the case may be, has been disclosed to Customer.

 

“Personal Information” means
any information about an identifiable individual but does not include business contact information (such as, an individual’s name,
title, business address, business phone and fax number) when such information is collected, used or disclosed for the purpose of contacting
such individual in their capacity as a director, officer, employee or other representative of an organization.

 

“Representative(s)” means collectively
employees, agents, independent contractors, software vendors, custom developers or consultants retained by or under the direction of a
Party in connection with this Agreement.

 

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		2.	SUBJECT OF THE AGREEMENT

 

This Agreement governs the long-term business
cooperation between the Parties, which includes providing/performing social media, content editorial, and business process outsourcing
services/work by the Executor for the needs of the Customer, for which the Customer has agreed to pay compensation to the Executor as
determined in accordance with Section 4 of this Agreement.

 

	 	3.	OBLIGATIONS OF THE AGREED PARTIES 

 

Obligations of the Executor:

 

Pursuant to the terms of this Agreement, the Executor
shall:‎

 

	 	●	Promptly perform and provide social media, content editorial, and BPO
    services according to the needs of the Customer;
	 	 	 
	 	●	Perform and provide all such social media, content editorial and BPO
    services with the attention of a good tradesman and in accordance with the interests of the Customer;
	 	 	 
	 	●	Promptly inform the Customer of delivery and payment terms, including
    promptly providing ‎the Customer with the Invoices required by Section 4 below; and
	 	 	 
	 	●	Perform other business activities as determined by the mutual agreement
    of the Parties pursuant to ‎this Agreement. ‎

 

Obligation of the Customer:

 

Pursuant to the terms of this Agreement, the Customer shall:‎

 

	 	●	Designate the services and work expected from the Executor;‎
	 	 	 
	 	●	Promptly deliver any documentation and information necessary for the execution of the ‎services and work provided under this Agreement;‎
	 	 	 
	 	●	Fulfill its payment obligations pursuant to Section 4 of this ‎Agreement;‎ and
	 	 	 
	 	●	Promptly inform the Executor of any potential delays of meeting its payment obligations herein. 

 

The Parties agree that all of the business decisions
regarding this long-term business ‎cooperation shall be mutually agreed to by the Parties in writing.

 

	 	4.	 FEE & PAYMENT TERMS

 

The Executor shall provide the Customer with monthly
invoices (each an “Estimated Invoice”) representing the Executor’s best estimate of fees for all services and
work performed by the Executor that were completed in the month immediately prior to the applicable Estimated Invoice (“Invoice
Period”). Each Estimated Invoice shall be issued on a Cost plus 10% basis.

 

Two months following the receipt by the Customer
of each applicable Estimated Invoice, the Executor shall provide a final invoice (“Final Invoice”) representing the
actual fees for all services and work performed by the Executor during the Invoice Period, less all amounts paid towards the applicable
Estimated Invoice. In the event that the Final Invoice reflects any overpayments made by the Customer to the Executor, the Executor shall
credit the Customer for such amounts.

 

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All invoices shall provide a detailed description
of the services provided, including any and all Costs incurred by the Executor which are exclusively attributable to the Customer rather
than of a nonexclusive and general nature, during the applicable period to which such invoice relates. Notwithstanding the foregoing,
details of Executor personnel providing services to the Customer shall not be detailed in invoices but rather provided by the Executor
to the Customer by way of a spreadsheet from time to time.

 

The Executor shall invoice the Customer in United
States Dollars and all invoices shall be payable by the Customer in United States Dollars, notwithstanding that Costs may have been incurred
by the Customer or may be chargeable by the Executor in Macedonian Denars. The Executor shall convert all Costs into United States Dollars
for the purposes of invoices on the last day of the particular month that is the subject of the invoice, based upon the average conversion
rate available to the Executor at the Executor’s bank during that month, or alternatively upon mutual agreement of the Parties,
on the actual date of the invoice.

 

Each invoice shall be paid by the Customer within
thirty (30) days of its receipt, provided, that, to the extent Customer disputes any such amounts, the Parties shall work in good faith
to resolve any such dispute. In addition to any other remedies available at law or equity, a monthly 1% late fee shall apply to any unpaid
amounts to the extent not disputed with respect to an applicable invoice and shall continue to accrue until all amounts owing in respect
of such invoice are paid in full.

 

All Costs reasonably incurred by the Executor
that do not exclusively relate to the provision of services to the Customer, including but not limited to, general overhead, lease costs,
costs of employees that are not exclusively dedicated to performing services for the Customer, will be allocated to the Customer on a
pro-rata basis based on the relative number of the Executor’s employees dedicated to the Customer compared to the total number of
employees dedicated to servicing the other clients that the Executor provides services to from time to time.

 

Executor personnel dedicated to providing services exclusively to the
Customer and such personnel’s related rates payable by the Customer, shall be itemized in writing by the Executor and subject to
mutual approval of the Parties. Upon the Customer’s prior written consent, members may be brought on or removed from the Executor’s
team to provide services to the Customer, and the rates payable, as well as all other information reasonably required by the Parties with
respect to personnel shall be mutually agreed to in writing by the Parties, acting in good faith.

 

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		5.	TERM AND TERMINATION

 

This Agreement shall commence on the Effective
Date and continue in full force and effect for an initial period of twenty-four (24) months thereafter (the “Initial Term”),
subject to automatic renewals for subsequent twelve (12) month periods thereafter (each, a “Renewal Term”)unless, at
least six (6) months prior to the expiration of the Initial Term or any Renewal Term, either Party provides written notice the other Party
of its intention not to renew the term of this Agreement.

 

Either Party may terminate this agreement with
written notice to the other Party upon the occurrence of any of the following events:

 

		a)	Either Party becomes bankrupt or insolvent, or takes action to become a voluntary bankrupt, makes an ‎assignment
for the benefit of its creditors or proposes to its creditors a reorganization, arrangement, composition or readjustment of its debts
or obligations or other-‎wise proposes to take advantage of or shelter under any law for the protection of ‎debtors;‎ or
	 	 	 

		b)	If the other Party materially breaches any material obligation of this Agreement and the breaching Party
fails to cure the breach within ninety (90) days‎ of being notified of the breach in writing by the other Party, subject to any reasonable
extension at the non-breaching Party’s discretion to the extent the breaching Party is working diligently to cure such breach. Notwithstanding
the foregoing, either Party may terminate this Agreement for failure to make any payments payable to the other Party pursuant to the terms
of this Agreement if such failure is not cured within ten (10) days ‎of being notified in writing of such failure by the other Party..

 

		6.	BUSINESS SECRET AND
                                            NON-DEFAMATION

 

The Executor shall not, during the term of this
Agreement or thereafter, directly or indirectly, in public or private, in any manner or in any medium whatsoever; a) deprecate, impugn
or otherwise make any comments, writings, remarks or other expressions that would, or could be construed to, defame the Customer, nor
shall the Executor assist any other person, firm or company in so doing; or b) communicate to any media, press, journalist, or other person
about the Customer or the Customer’s business or business operations, regardless of whether or not such communication would include
or be comprised of Confidential Information (as hereafter defined) unless required by law and in such event, the Executor shall provide
no less than ten (10) business days’ written notice to the Customer of same. The purpose of this provision is to maintain the Customer’s
absolute privacy to fullest extent of the law and the Executor acknowledges same.

 

		7.	CONFIDENTIAL INFORMATION

 

7.1 “Confidential Information” means
any materials and information provided by or on behalf of, or created, developed or invented by the Executor for or on behalf of, the
Customer, whether or not reduced to writing or whether or not patentable or protectable by copyright which the Executor receives or has
access to, or has conceived or may conceive of, or has developed in whole or in part, directly or indirectly, in connection with the Executor’s
work on behalf of the Customer, or otherwise through the use of any of the Customer’s software, platform, facilities or resources,
including:

 

		(i)	business information or trade secrets furnished by or on behalf of the Customer to the Executor, or created,
developed or invented by the Executor for or on behalf of the Customer, with respect to the Customer’s business and/or operations
whether in oral, written, graphic or machine-readable form, and all copies or reproductions thereof;

 

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		(ii)	such information as a director, officer or employee of the Customer may from time to time designate as
being included in the expression “Confidential Information”;
	 	 	 

		(iii)	information regarding production, editing, vetting, publishing, processing or clearing any video content
or other material for use with the Customer’s business, including but not limited to Rumble.com marketing techniques and arrangements,
mailing lists, purchasing information, pricing policies, publishing/and or editorial policies, content moderation policies and techniques,
quoting procedures, financial information, customer, prospect, and/or creator names and requirements, consultant, customer, client, creator,
supplier and distributor data and other materials or information relating to the Customer’s business and activities and the manner
in which the Customer does business;
	 	 	 

		(iv)	information regarding any video content creation rights or licenses or publishing rights or licenses which
the Customer may own, have option to acquire an interest in or may be considering acquiring an interest in;
	 	 	 

		(v)	any other materials or information related to the business or activities of the Customer which are not
generally known to others engaged in similar businesses or activities;
	 	 	 

		(vi)	all ideas which are derived from or related to Executor’s access to or knowledge of any of the above
enumerate materials and information;
	 	 	 

		(vii)	all computer programs including algorithms, specifications, flow charts, listings and object codes either
owned by the Customer or to which the Customer has access and wishes to keep confidential;
	 	 	 

		(viii)	all information relating to computer programs now existing or currently under development;
	 	 	 

		(ix)	customer/creator lists and records, including Personal Information;
	 	 	 

		(x)	Intellectual Property owned by the Customer, provided by the Customer to Executor or created, developed
or invented by Executor for or on behalf of the Company; and
	 	 	 

		(xi)	all other information a reasonable person would deem to be confidential or sensitive information.

 

7.2 Executor
acknowledges that the foregoing is intended to be illustrative only, and that other Confidential Information may currently exist or arise
in the future and that the failure to mark any of the Confidential Information as confidential, proprietary or “Confidential Information”
shall not affect its status as part of the Confidential Information under the terms of this Agreement.

 

7.3 The
Parties acknowledge and agree that the relationship between them is one of mutual trust and reliance. The Executor acknowledges that,
in and as a result of the Executor’s services on behalf of the Customer, the Customer shall have access to, make use of, acquire
or add to information and knowledge, including the Confidential Information, relating to all aspects of the business of Customer which
are confidential to and the exclusive property of the Customer, the disclosure of any of which to the Customer’s competitors, customers,
the general public, or otherwise, will be highly detrimental to the commercial interests of the Customer.

 

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7.4 The
Executor acknowledges that the Customer’s business interests cannot be properly protected from adverse consequences of the actions
of the Executor other than by the restrictions set forth in this Agreement.

 

7.5 The
Executor shall not, except with the prior written consent of the Customer, at any time during or following the term of the Executor’s
relationship with the Customer, directly or indirectly deal with, exploit, disclose, divulge, reveal, report, publish, transfer or use
for any purpose any of the information, including the Confidential Information, which has been obtained or disclosed to the Executor as
a result of the Executor’s relationship with the Customer to any person or entity, unless required by law and in such event, the
Executor shall provide no less than ten (10) business days’ written notice to the Customer of same. Executor shall only be permitted
to use the Confidential Information in furtherance of the services provided hereunder. Disclosure or use of the Confidential Information
by the Executor in breach of this Agreement shall be deemed to cause the Customer irreparable harm for which damages are not an adequate
remedy.

 

7.6 The
Executor agrees to use commercially reasonable means, not less than the means it uses to protect its own proprietary information, to safeguard
the Confidential Information. The Executor shall not at any time copy, duplicate, record or otherwise reproduce or transcribe the Confidential
Information nor any part thereof without the Customer’s prior written consent.

 

7.7 In
addition to its other obligations hereunder, Executor covenants and agrees:

 

(i) to only collect, use or disclose
Personal Information for purposes that a reasonable person would consider are appropriate in the circumstances and to conduct its activities
with respect to Personal Information in accordance with law;

 

(ii) where Personal Information is disclosed
by or on behalf of Customer to Executor, to: (A) use and disclose such Personal Information only for those purposes authorized by Customer,
(B) at the request and option of Customer return or cause to be returned, or destroy or cause to be destroyed, such Personal Information;
(C) promptly advise Customer of any request by an individual to access, correct or otherwise challenge the accuracy of such Personal Information,
or any other communication received by Executor in respect of such Personal Information, including, without limitation, any withdrawal
or variation of consent by an individual, and to work, in a timely manner, with Customer to respond to such requests (which response shall
be first approved by Customer), including without limitation, by providing access to, correcting, and ceasing to use, or disclose, such
Personal Information as requested by such individual; (D) use all reasonable efforts to protect and safeguard such Personal Information
including, without limitation, to protect such Personal Information from loss or theft, or unauthorized access disclosure, copying, use,
modification, disposal or destruction and promptly advise Customer should any such loss, theft or unauthorized activity occur; and (E)
only disclose such Personal Information to a third party with the prior written consent of Customer; and (F) only use, disclose, process,
store or enable access to such Personal Information in the Province of Ontario, Canada or such other jurisdictions as Customer may approve
in writing from time to time; and

 

(iii) where Personal Information is
disclosed by Executor to Customer, to only provide Personal Information to Customer where Executor has the legal right to do so, having
complied with its own privacy policies and all applicable law.

 

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		8.	CONFIDENTIALITY PROVISIONS FOR EXECUTOR’S REPRESENTATIVES

 

The Executor shall be responsible for any use
or disclosure of the Customer’s Confidential Information by any of its Representatives. The Executor will not show or otherwise
disclose Confidential Information to its Representatives unless;

 

		a)	such persons need to know such Confidential Information for the purposes of fulfilling the Executor’s
obligations under the Agreement, without the prior written consent of the Customer; and

 

		b)	each such employee, independent contractor, or consultant executes a valid and binding confidentiality
and invention assignment agreement sufficient for the Executor to fulfil its obligations under this agreement, and the Executor has furnished
an executed copy of such executed agreement to the Customer prior to any such employee, independent contractor, or consultant having access
to any Confidential Information of the Customer or services being performed by that person in relation to the Customer and the Executor’s
services on behalf of the Customer.

 

		9.	NON-SOLICITATION

 

During the term of this Agreement and for a period
of twelve (12) months following the termination of this Agreement, Executor agrees that it shall not directly or indirectly hire, solicit,
induce, recruit, encourage or otherwise endeavor to cause or attempt to cause any employee of Customer to terminate their relationship
with Customer; provided, that, the foregoing shall not be violated by (i) general advertising not targeted at any such employees (including
through use of any bona fide recruiting or employment agency not directed to target such employees), or (ii) the hiring of any such employees
who have terminated their employment with such Party at least 180 days prior to the date of hire by the other Party.

 

		10.	INTELLECTUAL PROPERTY
                                            RIGHTS

 

The Executor agrees that all right, title and
interest, including, without limitation, all Intellectual Property rights, in and to any content, deliverables, developments, inventions,
work product, materials, data, or information, including all computer programs (in source code or object code) and documentation related
thereto, which have been or will be provided by or on behalf of the Customer to the Executor or any of its Representatives, or created,
developed or invented by Executor or any of its Representatives for or on behalf of the Customer or in connection with or arising out
of any services provided to the Customer under this Agreement (including any code developed for the Customer’s platform, mobile
application and other software) (collectively, “Customer IP”) are owned and shall continue to be owned by the Customer.

 

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The Executor hereby irrevocably conveys,
transfers, and assigns, and upon creation of each element thereof automatically conveys, transfers and assigns, to the Customer all of
the Executor’s (including its Representatives’) rights, title, and interest in and to any and all Customer IP. This assignment
includes, without limitation, any and all rights to secure any patent, trade-mark, copyright, industrial design or other registrations
(including without limitation, any renewals or extensions thereto) with respect of the Customer IP, in Canada, the United States and elsewhere.

 

If any Customer IP cannot be assigned, the Executor
hereby grants to the Customer an exclusive, assignable, transferable, irrevocable, perpetual, non-terminable, worldwide, sublicenseable
(through one or multiple tiers), royalty-free, unlimited license to use, make, modify, sell, offer for sale, reproduce, distribute, create
derivative works of, publicly perform, publicly display, digitally perform and display and otherwise exploit such Customer IP in any media
or manner whatsoever, whether now known or hereafter known. Except in connection with any services provided to the Customer, the Executor
agrees not to (i) modify, adapt, alter, translate, or create derivative works from any Intellectual Property created in connection with,
or arising out of, any services provided to the Customer under this Agreement or (ii) merge any such Intellectual Property with other
Intellectual Property of the Customer or the Executor.

 

To the extent moral rights and other rights related
to paternity, integrity, disclosure and withdrawal (collectively, “Moral Rights”) may not be assignable under
applicable law and to the extent the following is allowed by the laws in the various countries where Moral Rights exist, the Executor
hereby irrevocably waives, and shall cause its Representatives to unconditionally and irrevocably waive, such Moral Rights and consents
to any action of the Customer that would violate such Moral Rights in the absence of such consent.

 

Executor shall, upon Customer’s request,
obtain from each and every one of its Representatives any agreement or assignment required to confirm ownership rights in the Customer
IP in favour of Customer, the licenses granted herein and the waiver of all moral rights therein.

 

To the extent Executor or its Representatives
incorporate into any Customer IP any pre-existing intellectual property owned by Executor or its Representatives or in which Executor
or its Representatives has an interest, Customer is hereby granted and shall have a nonexclusive, royalty-free, irrevocable, perpetual,
worldwide license to make, have made, modify, use, sell, license (at any level) and in any other way exploit such pre-existing intellectual
property as part of or in connection with such Customer IP, without obligation to account to, or obtain consent from, Executor or its
Representatives.

 

		11.	CERTAIN REPRESENTATIONS,
                                            WARRANTIES AND COVENANTS

 

The Executor hereby represents, warrants, and
covenants to the Customer as follows:

 

		a)	the Executor and its Representatives possess the necessary skill and expertise to provide the services
under this Agreement and shall provide such services in a professional manner in accordance with applicable law and industry standards
including best practices with respect to content moderation;‎

 

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		b)	the Executor employs qualified personnel and has implemented, and shall maintain, industry standard supervisory
and quality control measures;
	 	 	 

		c)	the Executor is the exclusive author, owner or rights holder, as applicable, of all Intellectual Property
relating to the services being provided under this Agreement;
	 	 	 

		d)	the Executor has unencumbered and uncontested title to Customer IP, including by obtaining valid assignments
of Intellectual Property rights from all of its Representatives, and has valid rights to convey to Customer all right, title and interest
in and to such Customer IP in accordance with this Agreement;
	 	 	 

		e)	to the knowledge of the Executor, no portion of: (i) any work product produced by the Executor in the
course of providing services to the Customer under this agreement; (ii) Customer IP; or (iii) any technology or software which Executor
uses to perform its services that comes into contact with the Customer IT Network; contains, or will contain, any material defects, Malicious
Code, security vulnerabilities, or protection features designed to prevent, or otherwise impair its use by Customer or any other person;‎
	 	 	 

		f)	to the knowledge of the Executor, the services and Customer IP provided by the Executor do not, and shall
not, infringe, induce the infringement of, or otherwise misuse, misappropriate, breach or violate any Intellectual Property rights or
other rights of any third party;‎
	 	 	 

		g)	the Customer IP provided by the Executor does not contain any Intellectual Property of any third party,
including open-source Intellectual Property, except as otherwise expressly approved by Customer in writing;
	 	 	 

		h)	all services and Customer IP will be provided and delivered in accordance with the terms of this Agreement
and in compliance in all material respects with applicable law, including, without ‎limitation, all applicable privacy laws and industry
standards relating to data security;
	 	 	 

		i)	all services and Customer IP will be provided and delivered in compliance in all material respects with
any service level agreements provided from time to time by Customer addressing, among other things, compliance with the Customer’s
content policies, acceptable content criteria, training material, review and escalation procedures and target turnaround times;
	 	 	 

		j)	the Executor shall use all commercially reasonable efforts to safeguard the Customer’s data (including
the data of its end users and content creators) and Customer IT Network by maintaining technical, organizational and physical measures
appropriate to the degree of sensitivity of such data, including by implementing industry standard disaster recovery and business continuity
plans; and
	 	 	 

		k)	the Executor shall report and provide reasonable and prompt assistance to the Customer in response to
any data breaches, including with respect to the invocation of Customer’s disaster recovery and business continuity plan.

 

		12.	RIGHT TO AUDIT

 

During the term of this Agreement and for a period
of one (1) year thereafter, the Customer shall have the right to conduct, from time to time, at its sole expense, audits of the Executor
in respect of this Agreement for the purpose of determining whether the Executor has complied, and is complying, with the terms of this
Agreement. The timing of each such audit shall be determined by the Customer, acting reasonably. Prior to accessing any of the Executor’s
premises or facilities, Customer agrees to provide reasonable notice of such audit to the Executor so as to disrupt, to the least extent
possible, the Executor’s business operations and agrees that its Representatives will comply with all reasonable security and confidentiality
policies of Executor.

 

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		13.	INDEMNIFICATION

 

The Customer agrees to defend, indemnify, and
hold harmless the Executor, its officers, directors, employees, agents, and/or affiliates harmless from and against any and all losses,
damages, liabilities, costs, fines, charges, disbursements, claims (including third-party claims), demands and expenses (including reasonable
legal fees and costs) (collectively, “Losses”) arising out of or in connection with:

 

		a)	The Customer’s material breach of any of its representations, warranties, or covenants contained
herein; and
	 	 	 

		b)	Any other Losses otherwise arising out of the performance by the Executor for, or the relationship of
the Executor with, the Customer, except to the extent arising out any material breach of the Executor of any terms of this Agreement.

 

The Executor agrees to defend, indemnify, and
hold harmless the Customer, its officers, directors, employees, agents, and/or affiliates harmless from and against any and all Losses
arising out of or in connection with the Executor’s material breach of any of its representations, warranties, or covenants contained
herein. The Executor’s obligation to indemnify the Customer shall be limited, in the aggregate, to the amount of fees received by
the Executor from the Customer in the twelve (12) months immediately prior to the event giving rise to the indemnification.

 

In no event shall any Party have any liability
under any provision of this Agreement for any punitive, incidental, consequential, special or indirect damages, including loss of future
revenue or income, loss of business reputation or opportunity relating to the breach or alleged breach of this Agreement, or diminution
of value or any damages based on any type of multiple, whether based on statute, contract, tort or otherwise, except in each case, where
such damages were caused by or resulted from, fraud or willful misconduct or a Party’s breach of Sections 6 or 7.

 

		14.	INJUNCTIVE RELIEF

 

The Executor acknowledges that the Customer will
be irreparably harmed if the obligations under this Agreement are not specifically enforced and the Customer would not have an adequate
remedy at law in the event of an actual or threatened violation by the Executor of its obligations. Therefore, the Executor agrees that
the Customer shall be entitled to an injunction or any appropriate decree of specific performance for any actual or threatened violation
or breach of this Agreement by the Executor and/or by any of its Representatives, without the necessity of the Customer showing actual
loss or damages.

 

		15.	FORCE MAJEURE

 

No party shall have any liability or responsibility
for any interruption, delay or other failure to fulfill any obligation under this Agreement, so long as and to the extent to which the
fulfillment of such obligation is prevented, frustrated, hindered or delayed as a consequence of circumstances of a Force Majeure, provided
that such party shall have exercised commercially reasonable efforts to minimize the effect of a Force Majeure on its obligations. In
the event of an occurrence of a Force Majeure, the party whose performance is affected thereby shall give notice (orally and in writing)
of suspension as soon as reasonably practicable to the other stating the date and extent of such suspension and the cause thereof, and
such party shall resume the performance of such obligations as soon as reasonably practicable upon the cessation of such Force Majeure
and its effects. For the purposes of this Agreement, “Force Majeure” means, with respect to a Party, an event beyond
the control of such Party (or any person acting on its behalf), including acts of God, storms, floods, riots, fires, earthquakes, sabotage,
civil commotion or civil unrest, interference by civil or military authorities, riots, insurrections or other hostilities, embargo, fuel
or energy shortage, acts of governmental authorities (including bank closings, seizures and other actions), acts of war (declared or undeclared)
or armed hostilities or other national or international calamity, pandemics and other regional or national health emergencies or one or
more acts of terrorism or failure or interruption of networks or energy sources.

 

    11

     

    

 

		16.	SURVIVAL

 

For greater certainty, the following Sections
of this Agreement shall survive the termination or expiry of this Agreement: Sections 4, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 19 and
21as those Sections, by their nature, are intended to survive the termination or expiry of this Agreement.

 

		17.	APPLICABLE LAW AND VENUE

 

This Agreement will be governed by and construed
in accordance with the laws of the Province of Ontario and the federal laws of Canada applicable therein, without giving effect to its
conflict of laws rules. Any dispute arising out of this agreement shall be subject to binding arbitration governed by the Commercial Arbitration
Rules of the Canadian Arbitration Association. The venue of the arbitration shall be Toronto. The arbitration charges will be split equally
between the Executor and the Customer. The award rendered by the arbitrator(s) shall be final and binding upon the Parties.

 

		18.	ASSIGNMENT 

 

This Agreement shall not be assigned by either Party without first
obtaining the prior written consent of the other Party; provided, that, without any such consent, Customer may assign its rights and obligations
under this Agreement to any of its affiliates, in connection with a merger or other acquisition of the Customer or to any entity that
acquires all or substantially all of the Customer’s assets related to the subject matter of this Agreement.

 

		19.	AMENDMENT

 

This Agreement may be modified or amended if the amendment is made
in writing and signed by the Parties.

 

		20.	COUNTERPARTS

 

This Agreement may be executed in several counterparts
and by original or facsimile or other electronic signature, each of which shall be deemed to be an original and all of which together
shall be deemed to constitute one and the same instrument.

 

		21.	ENTIRE AGREEMENT

 

This Agreement constitutes the entire agreement
and understandings, oral and written, between the Parties hereto and with respect to the subject matter hereof, and may not be altered,
amended or changed in any manner without the express written agreement of each Party.

 

[SIGNATURE PAGE FOLLOWS]

 

    12

     

    

 

	Executor:	 	Customer:
	Kosmik Development Skopje doo	 	Rumble Inc.
	 	 	 
	By: 	/s/ Anthony Naumoff	 	By:	/s/ Brandon Alexandroff
	Authorized Officer	 	Authorized Officer 
	Name: 	Anthony Naumoff	 	Name: 	Brandon Alexandroff
	Designation:	Director	 	Designation: 	CFO
	Date Signed:	 January 16, 2022	 	Date Signed: 	January 16, 2022

 

‎[A&R BCA - Kosmik Development Skopje
doo and Rumble Inc. Sig]nature Page]‎

 

 

13Document

LOCK-UP AND VOTING AGREEMENT
This LOCK-UP AND VOTING AGREEMENT (this “Agreement”) is made as of May 9, 2022 by and among OPKO Health, Inc., a Delaware corporation (the “Company”), and each other Person identified on Schedule A or Schedule B attached hereto (collectively, the “Holders”). Capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to such terms in the Merger Agreement (as defined below).
RECITALS
WHEREAS, concurrently with the execution and delivery of this Agreement, the Company, ModeX Therapeutics, Inc. (“ModeX Therapeutics”), Orca Acquisition Sub, Inc., a Delaware corporation and wholly owned subsidiary of the Company (“Merger Sub”), and Sellers’ Representative are entering into an Agreement and Plan of Merger (the “Merger Agreement”), pursuant to which Merger Sub will be merged with and into ModeX Therapeutics with ModeX Therapeutics surviving the merger (the “Merger”) as a wholly owned subsidiary of the Company, and each share of common stock, par value $0.0001 per share, of ModeX Therapeutics issued and outstanding immediately prior to the Merger (other than shares owned by the Company, ModeX Therapeutics and Merger Sub and as provided in Section 1.5(b) and Section 1.7 of the Merger Agreement) will be cancelled and converted into the right to receive shares of common stock, par value $0.01 per share, of the Company (the “Shares”), on the terms and subject to the conditions set forth in the Merger Agreement; and
WHEREAS, in connection with the transactions contemplated by the Merger Agreement, the Holders have agreed to certain transfer restrictions on, and/or voting requirements with respect to, the Shares on the terms and conditions set forth herein.
NOW, THEREFORE, in consideration of the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties to this Agreement hereby agree as follows: 
Section 1.    Definitions and Interpretation. 
(a)    Certain Definitions. For purposes of this Agreement the following terms shall have the meanings specified in this Section 1(a): 
“Affiliate” of any Person means any other Person directly or indirectly controlled by, controlling or under common control with such Person; provided that the Company and its Subsidiaries shall not be deemed to be Affiliates of any Holder. As used in this definition, “control” (including, with its correlative meanings, “controlling,” “controlled by” and “under common control with”) as applied to any Person shall mean possession, directly or indirectly, of power to direct or cause the direction of management or policies of such Person (whether through ownership of securities, by contract or otherwise). 
“Agreement” has the meaning set forth in the preamble.
“Board Nominees” means Elias A. Zerhouni, Gary J. Nabel and Alexis Borisy.
“Board of Directors” means the Board of Directors of the Company.
“Business Day” means any weekday other than a weekday on which banks in Miami, Florida are authorized or required to be closed.

“Capital Stock” means (i) with respect to any Person that is a corporation, any and all shares, interests or equivalents in capital stock of such corporation (whether voting or nonvoting and whether common or preferred), (ii) with respect to any Person that is not a corporation, individual or governmental entity, any and all partnership, membership, limited liability company or other equity interests of such Person that confer on the holder thereof the right to receive a share of the profits and losses of, or the distribution of assets of, the issuing Person, and (iii) any and all warrants, rights (including conversion and exchange rights) and options to purchase any security described in clause (i) or (ii) above. 
“Change of Control” means any one of the following: (i) the consummation of a merger or consolidation of the Company with or into any Person (except a merger or consolidation in which the holders of Capital Stock of the Company immediately prior to such merger or consolidation collectively continue to hold at least 50% of the earning power, voting power or Capital Stock of the surviving Person); (ii) the issuance, transfer, sale or disposition to another Person of the voting power or Capital Stock of the Company, if after such issuance, sale, transfer or disposition such Person would hold more than 50% of the voting power or Capital Stock of the Company; (iii) a sale, transfer or disposition of all or substantially all of the assets of the Company (which, for the elimination of doubt, shall be determined on a consolidated basis including the Company’s Subsidiaries); or (iv) dissolution, liquidation or winding up of the affairs of the Company.
“Code” means the U.S. Internal Revenue Code of 1986, as amended. 
“Company” has the meaning set forth in the preamble. 
“Covered Securities” shall mean, with respect to any Holder, all of the following: (i) any and all Shares which are owned by such Holder as of the Effective Date, (ii) any Shares issuable upon exercise, conversion or exchange of any securities of the Company which are owned by such Holder as of the Effective Date, (iii) any securities of the Company issued in respect of the Shares issued or issuable to any of the Holders by way of stock dividend or stock split or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization or otherwise and any Shares issuable upon conversion, exercise or exchange thereof, in each case to the extent relating to any securities of the Company which were owned by such Holder as of the Effective Date, and (iv) any other securities of the Company issued or issuable to any Holder that are convertible into or exercisable or exchangeable for Shares, whether at the option of the Holder or otherwise, in each case to the extent relating to any securities of the Company which were owned by such Holder as of the Effective Date.
“Effective Date” means the date on which the Merger becomes effective in accordance with the General Corporation Law of the State of Delaware.
“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder.
“Holder” has the meaning set forth in the recitals. 
“Lock-Up Term” has the meaning set forth in Section 2(a). 
“Merger” has the meaning set forth in the recitals. 
“Merger Agreement” has the meaning set forth in the recitals. 
“Merger Sub” has the meaning set forth in the recitals. 
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“ModeX Therapeutics” has the meaning set forth in the recitals. 
“Permitted Transferee” means, (i) with respect to any Holder who is an individual, (A) a member of such Holder’s immediate family (which shall mean any relationship by blood, marriage or adoption, not more remote than first cousin) or a trust, corporation, partnership or limited liability company for the benefit of an immediate family member, all of the beneficial interests of which shall be held by such Holder or one or more members of such Holder’s immediate family, (B) such Holder’s heirs, successors, administrators and executor and any beneficiary pursuant to will, other testamentary document or applicable laws of descent and (C) to any person pursuant to a qualified domestic relations order or other order of a court, administrative agency or other governmental authority, (ii) with respect to any Holder that is a Person other than an individual or a trust, any Affiliate of such Person, (iii) with respect to any Holder that is a trust, to a trustee or beneficiary of the trust and (iv) any institution qualified as tax-exempt under Section 501(c)(3) of the Code to the extent such institution receives Shares as a bona fide gift.
“Person” means any individual, firm, corporation, partnership, limited liability company, trust, incorporated or unincorporated association, joint venture, joint stock company, government (or an agency or political subdivision thereof) or other entity of any kind, and shall include any successor (by merger or otherwise) of such entity.
“Regulations” means the U.S. Treasury Regulations promulgated under the Code. 
“Shares” has the meaning set forth in the recitals. 
“Subsidiary” means, with respect to the Company, any corporation, limited liability company, partnership, association or other business entity of which (i) if a corporation, a majority of the total voting power of Capital Stock of such Person entitled (without regard to the occurrence of any contingency) to vote in the election of directors or managers is at the time owned or controlled, directly or indirectly, by the Company, or (ii) if a limited liability company, partnership, association or other business entity, either (x) a majority of the Capital Stock of such Person entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers, general partners or other oversight board vested with the authority to direct management of such Person is at the time owned or controlled, directly or indirectly, by the Company or (y) the Company or one of its Subsidiaries is the sole manager or general partner of such Person. 
“Transfer” means to, directly or indirectly, whether in one transaction or a series of transactions and whether by merger, consolidation, division, operation of law, or otherwise, (i) sell, transfer, assign or similarly dispose of, or enter into any contract, option or other arrangement or understanding with respect to the sale, transfer, assignment or similar disposition of, any interest in any Covered Securities owned by a Person or any interest (including a beneficial interest) in, or the ownership, control or possession of, any Covered Securities owned by a Person (provided, that, for the avoidance of doubt, the pledging of any interest in any Covered Securities owned by a Person shall not constitute a “Transfer” hereunder), (ii) enter into any swap, hedging, short sale, or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of any Covered Securities, whether any such transaction is to be settled by delivery of such securities, in cash or otherwise or (iii) publicly announce any intention to effect any transaction specified in clause (i) or (ii). 
“Voting Holder” has the meaning set forth in Section 4.
(b)    Interpretation. Unless otherwise noted:
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(i)    All references to laws, rules, regulations and forms in this Agreement shall be deemed to be references to such laws, rules, regulations and forms, as amended from time to time or, to the extent replaced, the comparable successor thereto in effect at the time.
(ii)    All references to agencies, self-regulatory organizations or governmental entities in this Agreement shall be deemed to be references to the comparable successor thereto.
(iii)    All references to agreements and other contractual instruments shall be deemed to be references to such agreements or other instruments as they may be amended from time to time.
Section 2.    Lock-Up. 
(a)    Each Holder set forth on Schedule A attached hereto hereby agrees that it will not Transfer any Covered Securities during the period commencing on the Effective Date and ending on, and including, the four-year anniversary of the Effective Date (the “Lock-Up Term”). 
(b)    Notwithstanding the foregoing restrictions on Transfer set forth in Section 2(a), each such Holder may: 
(i)    Transfer Covered Securities to any Permitted Transferee; 
(ii)    exercise any options or warrants to purchase Covered Securities (which exercises may be effected on a cashless basis to the extent the instruments representing such options or warrants permit exercises on a cashless basis); provided, however, that such Holder shall otherwise comply with any restrictions on Transfer applicable to such underlying Covered Securities; 
(iii)    Transfer any Covered Securities issuable upon exercise of any options that expire during the Lock-Up Term to the Company to satisfy tax withholding obligations as permitted by the compensation committee of the Board of Directors in its discretion pursuant to the Company’s equity incentive plans or arrangements; and
(iv)    Transfer Covered Securities to the Company pursuant to any contractual arrangement in effect on the Effective Date that provides for the repurchase by the Company of the Holder’s Covered Securities in connection with the termination of such Holder’s service to the Company.
provided, however, that in the case of any Transfer or distribution pursuant to Subsection 2(b)(i), (x) in each case such transferees must enter into a written agreement agreeing to be bound by this Agreement, including the restrictions on Transfer set forth in Section 2(a), and (y) such Permitted Transferee (other than a Permitted Transferee (i) as defined in clause (i)(B) or (C) thereof, or (ii) to whom a Transfer was made as part of a liquidating distribution) agrees to promptly Transfer such Covered Securities back to such Holder if such Permitted Transferee ceases to be a Permitted Transferee for any reason prior to the end of the Lock-Up Term. 
(c)    Notwithstanding anything to the contrary, the restrictions on Transfer set forth in Section 2(a) shall automatically terminate upon consummation of a Change of Control.
(d)    Each of the Holders acknowledges and agrees that any purported Transfer of Covered Securities in violation of this Agreement shall be null and void ab initio, and the Company shall not be required to register any such purported Transfer. Any Holder who effects or attempts to so effect a Transfer in violation of this Agreement will be deemed to have 
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committed a material breach of its obligations to the other Holders and to the Company hereunder.
Section 3.    Restrictive Legend; Stop Transfer Instruction.
Certificates, if any, representing the Covered Securities issued on or after the Effective Date must bear the following legend: 
“THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A LOCK-UP AND VOTING AGREEMENT AMONG OPKO HEALTH, INC. (THE “COMPANY”), THE OWNER OF SUCH SECURITIES, AND CERTAIN OTHER PARTIES THERETO THAT MATERIALLY RESTRICTS THE TRANSFERABILITY OF THE SECURITIES. BY ACCEPTING ANY INTEREST IN SUCH SHARES THE PERSON ACCEPTING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE PROVISIONS OF SAID AGREEMENT. A COPY OF THE AGREEMENT IS ON FILE WITH THE SECRETARY OF THE COMPANY.”
In order to ensure compliance with the provisions contained herein, each Holder agrees that the Company may issue appropriate “stop transfer” certificates or instructions with the Company’s transfer agent and registrar against the transfer of a Holder’s Covered Securities (irrespective of the date of issuance of such Covered Securities), or otherwise make adequate provision to restrict the transferability of the Covered Securities, in the event of a transfer other than in compliance with the provisions of this Agreement, and that it may make appropriate notations to the same effect in its records.
Section 4.    Voting Agreement.
(a)    For so long as either Elias A. Zerhouni or Gary J. Nabel  remains an employee of the Company or ModeX Therapeutics, each of the Holders set forth on Schedule B attached hereto (each such Holder, a “Voting Holder”) agrees to vote, or cause to be voted, all of such Voting Holder’s Covered Securities entitled to vote at any regular or special meeting of stockholders of the Company (or by written consent), if submitted for a stockholder vote by the Board of Directors, in favor of such Board Nominee’s election to the Board of Directors. 
(b)    To secure each Voting Holder’s obligations to vote his, her or its shares of Covered Securities in accordance with this Section 4, (i) each Voting Holder hereby appoints the Chairman of the Board of Directors and the Chief Executive Officer of the Company, or either of them (if not the same person) from time to time, or their respective designees, as such Voting Holder’s true and lawful proxy and attorney, with the power to act alone and with full power of substitution, to vote all of such Voting Holder’s Covered Securities in favor of the matters set forth in Section 4(a) and to execute all appropriate instruments consistent with this Agreement on behalf of such Voting Holder if, and only if, such Voting Holder fails to vote, or cause to be voted, all of such Voting Holder’s Covered Securities or execute such other instruments in accordance with the provisions of this Section 4 within [five (5)] days of the Company’s written request for such Voting Holder’s vote, written consent or signature.  The proxy and power granted by each Voting Holder pursuant to this Section 4 are coupled with an interest and are given to secure the performance of such Voting Holder’s obligations under this Section 4.  Each such proxy and power will be irrevocable during the Lock-Up Term.  The proxy and power, so long as any Voting Holder is an individual, will survive the death, incompetency and disability of such Voting Holder and, so long as any Voting Holder is a Person, other than an individual, will survive the merger or reorganization of such Voting Holder.
Section 5.    General Provisions. 
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(a)    Amendments and Waivers. The provisions of this Agreement may be amended, modified or waived only with the prior written consent of the Company, the Holder affected by such amendment, modification or waiver, and Sellers’ Representative. The failure or delay of any Person to enforce any of the provisions of this Agreement shall in no way be construed as a waiver of such provisions and shall not affect the right of such Person thereafter to enforce each and every provision of this Agreement in accordance with its terms. A waiver or consent to or of any breach or default by any Person in the performance by that Person of his, her or its obligations under this Agreement shall not be deemed to be a consent or waiver to or of any other breach or default in the performance by that Person of the same or any other obligations of that Person under this Agreement. 
(b)    Remedies. The parties to this Agreement and their successors and permitted assigns shall be entitled to seek enforcement of their rights under this Agreement specifically (without posting a bond or other security), to recover damages caused by reason of any breach of any provision of this Agreement and to exercise all other rights existing in their favor. The parties hereto and their successors and assigns agree and acknowledge that a breach of this Agreement would cause irreparable harm and money damages would not be an adequate remedy for any such breach and that, in addition to any other rights and remedies existing hereunder, any party shall be entitled to seek specific performance and/or other injunctive relief from any court of law or equity of competent jurisdiction (without posting any bond or other security) in order to enforce or prevent violation of the provisions of this Agreement. 
(c)    Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited, invalid, illegal or unenforceable in any respect under any applicable law or regulation in any jurisdiction, such prohibition, invalidity, illegality or unenforceability shall not affect the validity, legality or enforceability of any other provision of this Agreement in such jurisdiction or in any other jurisdiction, but this Agreement shall be reformed, construed and enforced in such jurisdiction as if such prohibited, invalid, illegal or unenforceable provision had never been contained herein. 
(d)    Entire Agreement. Except as otherwise provided herein, this Agreement contains the complete agreement and understanding among the parties hereto with respect to the subject matter hereof and supersedes and preempts any prior understandings, agreements or representations by or among the parties hereto, written or oral, which may have related to the subject matter hereof in any way. 
(e)    Successors and Assigns; Third Party Beneficiaries. This Agreement shall bind and inure to the benefit and be enforceable by the Company and its successors and assigns and the Holders and their respective successors and assigns (whether so expressed or not). In addition, whether or not any express assignment has been made, the provisions of this Agreement which are for the benefit of Holders are also for the benefit of, and enforceable by, any subsequent or successor Holder. No Person other than the parties hereto and their successors and permitted assigns is intended to be a beneficiary of this Agreement; provided that, the Board Nominees shall be third-party beneficiaries of Section 4 of this Agreement, entitled to enforce the terms hereof.
(f)    Notices. Any notice, demand or other communication to be given under or by reason of the provisions of this Agreement shall be in writing and shall be deemed to have been given or delivered (i) when delivered personally to the recipient, (ii) when sent by electronic mail (provided that the sending party does not receive an automatically generated message from the recipient’s email server that such email could not be delivered to such recipient) if sent during normal business hours of the recipient but, if not, then on the next Business Day, (iii) one Business Day after it is sent to the recipient by reputable overnight courier service (charges 
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prepaid) or (iv) three Business Days after it is mailed to the recipient by first class mail, return receipt requested. Such notices, demands and other communications shall be sent to the Company at the address specified below and to any other party subject to this Agreement at such address as indicated on Schedule A hereto, or at such address or to the attention of such other Person as the recipient party has specified by prior written notice to the sending party or as is on file for such Person at the Company. Any party may change such party’s address for receipt of notice by providing prior written notice of the change to the sending party as provided herein. 
The Company’s address is: 
OPKO Health, Inc.
4400 Biscayne Blvd.
Miami, FL 33137
Attention: Steven D. Rubin; Camielle Green
E-mail: srubin@opko.com; legalnotices@opko.com
With a copy (which shall not constitute notice) to: 
Greenberg Traurig 
333 S.E. 2nd Avenue
Suite 4400 
Miami, FL 33131 
Attention:   Robert L. Grossman; Drew M. Altman 
E-mail:        grossmanb@gtlaw.com / altmand@gtlaw.com 
or to such other address or to the attention of such other Person as the Company has specified by prior written notice to the sending party. 
(g)    Governing Law. All issues and questions concerning the construction, validity, interpretation and enforcement of this Agreement and the exhibits and schedules hereto, and the relative rights of the Company and the Holders hereunder, shall be governed by, and construed in accordance with, the laws of the State of Delaware, without giving effect to any choice of law or conflict of law rules or provisions (whether of the State of Delaware or any other jurisdiction) that would cause the application of the laws of any jurisdiction other than the State of Delaware. 
(h)    MUTUAL WAIVER OF JURY TRIAL. AS A SPECIFICALLY BARGAINED FOR INDUCEMENT FOR EACH OF THE PARTIES HERETO TO ENTER INTO THIS AGREEMENT (AFTER HAVING THE OPPORTUNITY TO CONSULT WITH COUNSEL), EACH PARTY HERETO EXPRESSLY WAIVES THE RIGHT TO TRIAL BY JURY IN ANY LAWSUIT OR PROCEEDING RELATING TO OR ARISING IN ANY WAY FROM THIS AGREEMENT OR THE MATTERS CONTEMPLATED HEREBY. 
(i)    CONSENT TO JURISDICTION AND SERVICE OF PROCESS. EACH OF THE PARTIES, AND EACH OF THEIR SUCCESSORS AND ASSIGNS, IRREVOCABLY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE COURT OF CHANCERY OF THE STATE OF DELAWARE OR, ONLY IF SUCH COURT LACKS JURISDICTION, THE STATE OR FEDERAL COURTS IN THE STATE OF DELAWARE, FOR THE PURPOSES OF ANY SUIT, ACTION OR OTHER PROCEEDING ARISING OUT OF THIS AGREEMENT, ANY RELATED AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY OR THEREBY. EACH OF THE PARTIES HERETO, AND EACH OF THEIR SUCCESSORS AND ASSIGNS, IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY OBJECTION TO THE LAYING OF VENUE OF ANY ACTION, SUIT OR PROCEEDING ARISING OUT OF THIS AGREEMENT, ANY RELATED DOCUMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY AND 
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THEREBY IN THE AFOREMENTIONED COURTS, AND HEREBY AND THEREBY FURTHER IRREVOCABLY AND UNCONDITIONALLY WAIVES AND AGREES NOT TO PLEAD OR CLAIM IN ANY SUCH COURT THAT ANY SUCH ACTION, SUIT OR PROCEEDING BROUGHT IN ANY SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. 
(j)    Descriptive Headings; Interpretation. The descriptive headings of this Agreement are inserted for convenience only and do not constitute a part of this Agreement. The use of the word “including” in this Agreement shall be by way of example rather than by limitation. 
(k)    Interpretation. The parties hereto acknowledge and agree that (i) each party hereto and its counsel reviewed and negotiated the terms and provisions of this Agreement and have contributed to its revision, (ii) the rule of construction to the effect that any ambiguities are resolved against the drafting party shall not be employed in the interpretation of this Agreement and (iii) the terms and provisions of this Agreement shall be construed fairly as to all parties hereto, regardless of which party was generally responsible for the preparation of this Agreement.
(l)    Other Agreements. Nothing contained in this Agreement shall be deemed to be a waiver of, or release from, any obligations any party hereto may have under, or any restrictions on the transfer of securities of the Company imposed by any other agreement.
(m)    Counterparts. This Agreement may be executed in multiple counterparts, any one of which need not contain the signature of more than one party, but all such counterparts taken together shall constitute one and the same agreement. 
(n)    Electronic Delivery. This Agreement and any amendments hereto, to the extent executed and delivered by means of Docusign or a photographic, photostatic, facsimile or similar reproduction of such signed writing using a facsimile machine or electronic mail shall be treated in all manner and respects as an original agreement or instrument and shall be considered to have the same binding legal effect as if it were the original signed version thereof delivered in person. No party hereto or to any such agreement or instrument shall raise the use of Docusign, a facsimile machine, or electronic mail to deliver a signature or the fact that any signature or agreement or instrument was transmitted or communicated through the use of Docusign, a facsimile machine, or electronic mail as a defense to the formation or enforceability of a contract, and each such party forever waives any such defense. 
(o)    Further Assurances. In connection with this Agreement and the transactions contemplated hereby, each Holder shall execute and deliver any additional documents and instruments and perform any additional acts that may be necessary or appropriate to effectuate and perform the provisions of this Agreement and the transactions contemplated hereby.
(p)    Not a Voting Trust. This Agreement is not a voting trust governed by Section 218 of the Delaware General Corporation Law and should not be interpreted as such.
(q)    Dilution. If, from time to time, there is any change in the capital structure of the Company by way of a stock split, stock dividend, combination or reclassification or similar change affecting all issued and outstanding Shares as a class, appropriate adjustment shall be made in the provisions hereof so that the rights and privileges granted hereby shall continue. In the event of any issuance of Capital Stock of the Company hereafter to any of the parties hereto in connection with any change in the capital structure of the Company as described in the immediately preceding sentence, such shares shall become subject to this Agreement and shall be endorsed with the legend set forth in Section 3 of this Agreement.
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[signature pages follow]

9

IN WITNESS WHEREOF, the parties have executed this Lock-Up and Voting Agreement as of the date first written above.
									
			
	OPKO HEALTH, INC.
		
	By:	 	  /s/ Steven D. Rubin               
		 	Name: Steven D. Rubin
		 	Title: Executive Vice President, Administration

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IN WITNESS WHEREOF, the parties have executed this Lock-Up and Voting Agreement as of the date first written above. 
 
HOLDERS:

						
	FROST GAMMA INVESTMENTS TRUST
		
		
	By:	/s/ Phillip Frost
	Name:	Phillip Frost, M.D.
	Title:	Trustee

						
	PHILLIP FROST, M.D.
		
		
		/s/ Phillip Frost
		
		

						
	JANE HSIAO, Ph.D., MBA
		
		
		/s/ Jane Hsiao

		
		

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Schedule A

Frost Gamma Investments Trust

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Schedule B
Phillip Frost, M.D.
Jane Hsiao, Ph.D., MBA

13

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