Document:

EX-10.9

 Exhibit 10.9 

ZS PHARMA, INC. 

FORM OF EMPLOYMENT AGREEMENT 

This Employment Agreement (the “Agreement”) is entered into between ZS Pharma, Inc., a Delaware corporation (“ZS Pharma”),
and the undersigned employee (“Employee”). In consideration of the premises and the following mutual terms and conditions, ZS Pharma and Employee agree as follows: 

1. Employment At Will. Employee is employed by ZS Pharma as an employee at will. Nothing in ZS Pharma’s policies is intended
to create a promise or representation of continued employment or employment for a fixed period of time. Similarly, no wage increase, promotion, length of service, oral promise by any person, or any other aspect of the employment relationship that
may arise shall change the ability of either ZS Pharma or Employee to terminate the employment relationship at will. 
 2. Title,
Duties and Compensation. 
 (a) Title. Employee shall initially have the title of
             of ZS Pharma. Such title may be changed from time to time by ZS Pharma. 

(b) Duties. Employee shall perform and discharge well and faithfully for ZS Pharma Employee’s duties and
responsibilities as an employee of ZS Pharma, including such management activities as are assigned to Employee from time to time in connection with the business of ZS Pharma and its Affiliates. Employee shall perform his or her duties at all times
as directed. Employee shall commit all or substantially all of Employee’s business time, energies, attention and skill on a full-time basis to the business and operations of ZS Pharma and its Affiliates. 

(c) Compensation. As full compensation for all services to be rendered by Employee to ZS Pharma, Employee shall receive
the following compensation and benefits: 
 (1) Base Salary. Employee shall receive cash compensation in the amount
of $             per pay period $             if annualized), which shall be paid to Employee in regular intervals in accordance
with ZS Pharma’s customary payroll schedules for salaried employees (“Base Salary”). The Base Salary payable to Employee may be increased by the Board of Directors (or the Compensation Committee of the Board of Directors) in its sole
discretion. 
 (2) Annual Bonus. With respect to each fiscal year that ends during the Term, Employee shall be
eligible to receive an annual cash bonus opportunity equal to an amount up to thirty percent of Employee’s annualized Base Salary (“Annual Bonus”), based upon individual and ZS Pharma annual performance targets (“Performance
Targets”) established by mutual agreement of Employee and the Board of Directors (taking into account the recommendation of the Compensation Committee); provided, that if Employee and the Board of Directors

 
cannot mutually agree on the Performance Targets for any fiscal year, the Performance Targets for such fiscal year shall be as determined by the Board of Directors in its sole discretion. The
amount of the Annual Bonus, if any, shall be based upon Employee’s and ZS Pharma’s attainment of the Performance Targets as determined by the Board of Directors (or the Compensation Committee of the Board of Directors) in its sole
discretion. If target Performance Target levels are not attained with respect to a given year, the Annual Bonus shall be payable with respect to such year in an amount, if any, as determined by the Board of Directors (or the Compensation Committee
of the Board of Directors) in its sole discretion. Each such Annual Bonus shall be payable on such date as is determined by the Board of Directors in its sole discretion, but in any event on or prior to March 15 immediately following the fiscal
year with respect to which such Annual Bonus relates. Notwithstanding any other provision of this Section 2, a bonus shall be payable with respect to a fiscal year if the Employee earns such bonus and is employed by ZS Pharma on December 31 of
the applicable fiscal year, whether or not the Employee remains employed with ZS Pharma on the applicable bonus payment date. 

(3) Stock Options. Subject to the stockholder approval of the increase in the number of shares of Common Stock
authorized for issuance under the Company’s 2008 Stock Incentive Plan, as amended, employee shall be granted options to purchase              shares of ZS Pharma’s common stock
(the “Stock Options”) pursuant to the Stock Option Plan. The exercise price of the Stock Options will be equal to the fair market value of the common stock on the date of the grant. At the end of the first 12-month period following the
Effective Date, 25% of the Stock Options shall vest and may be exercised. The remaining 75% of the Stock Options shall vest and may be exercised in equal monthly installments over the 12-month to 48-month period following the Effective Date. Upon
the occurrence of a Liquidity Event, the Stock Options will become fully vested and exercisable. 
 (4) Welfare and
Fringe Benefits. Employee shall be entitled to participate in, and ZS Pharma will reimburse Employee for the premiums, expenses and charges (if any) for Employee’s share of, any medical, dental, vision and term life benefits available from
time to time to other officers of ZS Pharma under the terms and conditions of such plans or programs. ZS Pharma shall make those reimbursement payments to Employee during the term of his or her employment and within thirty (30) days after
receiving Employee’s statement for such premiums, expenses and charges, along with reasonable supporting documentation. 

(5) Vacation. Employee shall receive twenty days of paid time off per year (“Vacation”), to be taken at such
times and intervals as shall be mutually determined by Employee and ZS Pharma. At the end of each year, any unused Vacation shall be forfeited. 

  
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 3. Termination. 

(a) Termination by ZS Pharma or Employee. Except as provided in Section 7, Employee may terminate his or her
employment voluntarily at any time, with or without Good Reason, and ZS Pharma may terminate Employee’s employment at any time, with or without Cause. In the event that Employee or ZS Pharma terminates the employment relationship, the party
initiating the termination shall provide the other party with Notice of Termination. 
 (b) Termination upon Death. If
Employee dies at a time when Employee is employed by ZS Pharma, both this Agreement and Employee’s employment shall terminate as of the date of Employee’s death. 

(c) Termination upon Disability. If Employee becomes physically or mentally Disabled, whether totally or partially,
during Employee’s employment, ZS Pharma, by written notice to Employee, may terminate Employee’s employment, in which event this Agreement shall terminate ten (10) days after the date upon which ZS Pharma shall have given notice to
Employee of its intention to terminate Employee’s employment because of Disability. 
 4. Compensation Upon Termination.

 (a) By ZS Pharma Without Cause Or By Employee With Good Reason. If Employee’s employment is terminated by ZS
Pharma without Cause or by Employee for Good Reason, ZS Pharma will provide compensation and benefits to Employee on the following terms: 

(1) Base Salary. As soon as practicable (or otherwise as required by law) following the Termination Date, ZS Pharma
will pay Employee’s Base Salary earned through the Termination Date at the rate in effect on the date Notice of Termination is given. 

(2) Severance Pay. As soon as practicable, but no later than ten days following the Termination Date, ZS Pharma will
provide Employee with a release of claims in a form satisfactory to ZS Pharma. On the first business day following the expiration of the seventy-five day period following the occurrence of the Termination Date, so long as Employee has timely
executed and returned the release of claims without revocation, ZS Pharma will provide a lump sum payment of severance pay to Employee in an amount equal to twelve months of Employee’s Base Salary at the rate in effect on the date Notice
of Termination is given (the “Severance Pay”). 
 (3) Welfare and Fringe Benefits. At the time of payment
of the Severance Pay and subject to Employee’s execution and return of the release described above, ZS Pharma will also pay Employee, in lieu of the level of coverage for Employee and his or her dependents under ZS Pharma’s welfare and
fringe benefit plans that applied during the period of active employment, an 

  
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amount equal to the product of (i) twenty-four times (ii) the amount that was paid by, allocated to, or otherwise attributed to ZS Pharma as its employer premium contribution with
respect to Employee and his or her dependents, if any, under ZS Pharma’s welfare and fringe benefit plans during the month immediately preceding the month in which Employee’s termination occurred. 

(4) Stock Option Plan. 

(i) Stock Options. As of the Termination Date on which Employee is terminated by ZS Pharma without Cause or his or her
employment is terminated by Employee with Good Reason, Employee’s Stock Options awarded under the Stock Option Plan will become fully vested and exercisable, and, for the avoidance of doubt, any employment termination by Employee with Good
Reason will be deemed a termination by ZS Pharma without cause under the terms of the Stock Option Plan. 
 (ii)
Amendment of Option Agreements. To the extent that the provisions of this subsection are inconsistent with the provisions of Employee’s Option Agreements, Employee and ZS Pharma hereby amend those Option Agreements to include the
provisions of this subsection, which supersede any inconsistent provisions of the Option Agreements. 
 (b) Upon Other
Termination of Employment. If Employee’s employment is terminated by ZS Pharma for Cause, by Employee without Good Reason, or because of death or Disability, ZS Pharma will pay Employee’s Base Salary earned through his or her last day
of employment and provide benefits under the Stock Option Plan and welfare and fringe benefit plans in accordance with the respective terms of those plans. 

5. Confidentiality; Restrictive Covenants. 

(a) Confidentiality. 

(1) Confidential Information. Employee recognizes and acknowledges that the Confidential Information, as it may exist
from time to time, is a valuable, special, and unique asset of ZS Pharma, the knowledge and use of which provides ZS Pharma with a competitive advantage over its competitors. Employee desires to obtain ZS Pharma’s Confidential Information to
aid in the effective performance of the Employee’s duties as an employee of ZS Pharma. Accordingly, from the Effective Date, and until the tenth (10th) anniversary of such date or during
the period during which Employee is employed by ZS Pharma, Employee shall hold in strict confidence and shall not, directly or indirectly, disclose or reveal to any person, or use for Employee’s own personal benefit or for the benefit of anyone
else, any Confidential Information of any kind, nature, or description (whether or not acquired, learned, obtained, or developed by Employee alone or in conjunction with others) belonging to or concerning ZS Pharma or its affiliates, agents, or
employees, or any of its development or commercial partners, customers, distributors, licensees, suppliers, 

  
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or others with whom ZS Pharma, or its affiliates, agents, or employees, now or hereafter have a business relationship, except (a) with the prior written consent of an authorized
representative of ZS Pharma. Employee acknowledges that the unauthorized use or disclosure of Confidential Information would be detrimental to ZS Pharma and would reasonably be anticipated to materially impair ZS Pharma’s value. 

(2) Non-Disclosure of Third Party Confidential Information. Employee will not, during the course of Employee’s
employment with ZS Pharma, breach any other agreement obligating Employee to keep in confidence any Confidential Information acquired by Employee in confidence or in trust prior to beginning employment with ZS Pharma. Employee further will not
disclose to ZS Pharma or any of its affiliates, agents, or employees, or induce ZS Pharma or any of its affiliates, agents, or employees to use in any unauthorized manner, any Confidential Information belonging to any third party acquired by
Employee in confidence or in confidence or in trust from such third party. Employee represents that Employee either (a) is under no contractual obligation to a third party due to having executed a restrictive covenant or confidentiality or
non-competition agreement, or (b) has provided ZS Pharma with a copy of any such covenant or agreement for review by ZS Pharma prior to beginning employment with ZS Pharma, which copy is attached to this Agreement as Exhibit A. 

(3) Return of Confidential Information and Other Documents. Employee agrees to promptly deliver to ZS Pharma, upon
termination of Employee’s employment with ZS Pharma, or at any other time when ZS Pharma so requests, all Confidential Information and any derivations, summaries, memoranda, notes, records, drawings, manuals, and other documents (and all copies
thereof and therefrom) in any way relating to the business or affairs of ZS Pharma or any of its development or commercial partners, customers, distributors, licensees, or suppliers, whether made or compiled by Employee or furnished to Employee by
ZS Pharma or any of its affiliates, agents, employees, consultants, customers, development or commercial partners, distributors, licensees, or suppliers, that Employee has received or generated. Employee confirms that all such derivations,
summaries, memoranda, notes, records, drawings, manuals, and other documents (and all copies thereof and therefrom) constitute the exclusive property of ZS Pharma. 

(4) Subpoena or Court Order. In the event Employee becomes aware of any proceeding that might result in becoming
legally compelled (by deposition, interrogatory, request for documents, subpoena, court order, or similar process) to disclose any Confidential Information, Employee shall promptly notify ZS Pharma of such proceeding so that ZS Pharma may seek a
protective order or other appropriate remedy or waive compliance with the terms of this Agreement with respect to such Confidential Information. In the event that Employee becomes legally compelled to disclose any Confidential Information and such
protective order or other remedy is not obtained, or that ZS Pharma waives compliance with the provisions hereof, Employee agrees to disclose only that portion of the Confidential Information that Employee is legally required to disclose. 

  
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 (b) Non-Competition and Non-Solicitation. 

(1) During the time which Employee is employed by ZS Pharma (the “Employment Period”) and for a period of one
(1) year thereafter, Employee shall not, directly or indirectly: (i) own, engage in, conduct, manage, operate, participate in, be employed by, be connected in any manner whatsoever with, or render services or advice to (whether for
compensation or without compensation), any other person or business entity which, in the judgment of ZS Pharma, directly or indirectly competes with the Business of ZS Pharma, or (ii) recruit or otherwise solicit or induce any employee of ZS
Pharma to terminate his or her engagement with, or otherwise cease his or her relationship with, ZS Pharma in order to join any person or entity which, in the sole judgment of ZS Pharma, competes with the Business of ZS Pharma. 

(2) The obligations set forth in paragraphs 5(b)(1) above shall not restrict Employee’s right to invest in the securities
(not to exceed 1% of the outstanding securities of any class) of any publicly-held corporation in the management of which Employee does not participate. 

(3) The restrictions set forth in paragraphs 5(b)(1) are considered by the parties to this Agreement to be reasonable for the
purposes of protecting the Business of ZS Pharma. However, if any such restriction is found by any court of competent jurisdiction to be unfair because it extends for too long a period of time or over too great a range of activities or in too broad
of a geographic area, it shall be interpreted to extend only over the maximum period of time, range or activities or geographic area to which it may be enforceable. 

(c) Intellectual Property. 

(1) Employee shall promptly disclose to ZS Pharma all ideas, inventions, discoveries, processes, designs, methods, substances,
articles, computer programs, derivative works, and improvements, whether or not patentable or copyrightable (all of the foregoing being hereinafter collectively called “Intellectual Property”), that Employee conceives, invents, discovers,
creates, or develops, alone or with others, during the period of Employee’s employment by ZS Pharma, if such conception, invention, discovery, creation, or development: (i) occurs in the course of Employee’s employment with ZS Pharma;
(ii) occurs with the use of ZS Pharma’s or any of its affiliates’, agents’, or employees’ time, materials, or facilities; or (iii) could reasonably be considered to relate or pertain in any way to ZS Pharma’s or
any of its affiliates’, agents’, or employees’ present or anticipated purposes, activities, or affairs. 

  
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 (2) Employee agrees to assign and hereby irrevocably assigns to ZS Pharma, and
its successors, assigns, or designees, all of Employee’s right, title, and interest in and to all Intellectual Property that Employee is obligated to disclose to ZS Pharma pursuant to Section 6(a) and Employee acknowledges and agrees that
all such Intellectual Property is the exclusive property of ZS Pharma. Employee further acknowledges and agrees that any and all works of authorship including, without limitation, copyrights in any creation, modification, or enhancement of any
software or computer program, produced in the course of Employee’s work for or employment by ZS Pharma, solely or with others, are works made for hire and constitute the sole property of ZS Pharma. Employee agrees to assign and hereby
irrevocably assigns to ZS Pharma, and its successors, assigns or designees, all of Employee’s right, title, and interest in and to such works of authorship. Employee hereby irrevocably relinquishes and forever waives for the benefit of ZS
Pharma any moral rights (defined as either any right to claim authorship of a work or any right to object to any distortion or other modification of a work, or any similar right existing under the law of any country in the world or under any
international agreement) in any work of authorship. 
 (3) Employee shall assist ZS Pharma in the preparation of and shall
execute and deliver all disclosures, applications for patents or reissue of patents, rights of priority, assignments, and other documents, give all testimony, and in general undertake all lawful and reasonable actions requested by ZS Pharma to
obtain, maintain, and enforce United States and foreign patents and to obtain, maintain, and enforce on behalf of ZS Pharma or its designee legal title and all rights in and to all Intellectual Property referred to in the preceding provisions of
this Section 5(c). 
 (4) Employee shall prepare and maintain adequate and current written records of all Intellectual
Property within the scope of Sections 5(c)(1) through 5(c)(3) in the form of notes, sketches, drawings, memoranda, or reports, all of which shall be promptly submitted by Employee to ZS Pharma and shall be owned exclusively by ZS Pharma. 

(5) Employee shall perform Employee’s obligations under this Section 5(c) at ZS Pharma’s expense, without any
additional compensation other than that which Employee receives by reason of Employee’s employment with ZS Pharma, or pursuant to a separate agreement between ZS Pharma and Employee, if any, of ZS Pharma that may be in effect from time to time.

 (6) If ZS Pharma or its designee is unable for any reason whatsoever to obtain Employee’s signature to any documents
that Employee is required or may be required by ZS Pharma to sign pursuant to this Section 5(c), Employee hereby irrevocably designates and appoints ZS Pharma as Employee’s agent and attorney-in-fact and hereby grants to ZS Pharma a power
of attorney (in each case with full power of substitution) to act for and on behalf of Employee and in Employee’s stead to execute, deliver, and file all such documents (including, without limitation, all applications for United States and
foreign patents or for the reissue of such patents) and to do all other lawful acts that Employee is required or may be required by ZS Pharma to do pursuant to this Section 5(c). 

  
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 (d) ZS Pharma shall be entitled to all lawful remedies available to it for the
enforcement of the covenants contained in this Section 5 and such provisions may be enforced by an action, suit or proceeding (a “Proceeding”) in any court of competent jurisdiction. In addition, Employee acknowledges and agrees that
the provisions of Section 5 shall constitute separate covenants which shall be enforceable during and after the time Employee is employed by ZS Pharma. Without limiting the generality of the foregoing, each of the parties hereto
acknowledges and agrees that the other party hereto would be irreparably damaged if any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that each
party hereto shall be entitled to preliminary and permanent injunctive relief to prevent breaches of the provisions of this Agreement by the other party hereto without the necessity of proving actual damages or of posting any bond, and to enforce
specifically the terms and provisions hereof, which rights shall be cumulative and in addition to any other remedy to which a party hereto may be entitled hereunder or at law or equity. 

(e) The covenants contained in Section 5 will be construed as independent of any other provisions of this Agreement, and
the existence of any claim or cause of action of the Employee against ZS Pharma or any officer, manager or equity owner of ZS Pharma, whether predicated on this Agreement or otherwise, shall not constitute a defense to the enforcement by
ZS Pharma of the covenants of Employee contained in this Section 5. 
 6. Code Section 409A. Despite any other
provisions of the Agreement to the contrary, any Deferred Compensation payments otherwise due under this Agreement will be paid in accordance with this Section. 

(a) Post-Termination Payment Suspension. If as of the date his or her employment terminates, Employee is a “key
employee” within the meaning of Code Section 416(i), without regard to paragraph 416(i)(5), and ZS Pharma has stock that is publicly traded on an established securities market or otherwise, any Deferred Compensation payments otherwise
payable because of employment termination will be suspended until the first day of the seventh month following the month in which the Employee’s last day of employment occurs, and the Deferred Compensation payments in the seventh month will
include all previously suspended amounts. 
 (b) Interpretation. This Agreement shall be interpreted and applied in a
manner consistent with the standards for nonqualified deferred compensation plans established by Code Section 409A and its interpretive regulations and other regulatory guidance. To the extent that any terms of the Agreement would subject
Employee to gross income inclusion, interest, or additional tax pursuant to Code Section 409A, those terms are to that extent superseded by, and shall be adjusted to the minimum extent necessary to satisfy or be excluded from coverage by, the
applicable Code Section 409A standards. 

  
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 (c) Reimbursement. To the extent any payment hereunder is deemed a
reimbursement that is subject to Code Section 409A, (i) in no event shall any reimbursement payment be made later than the close of the taxable year following the taxable year in which the reimbursable expense (or similar charge) was
incurred, and (ii) the right to reimbursement shall not be subject to liquidation or exchange for another benefit. 
 7.
Obligation To Remain an Employee. In the event any other corporation, person or group of persons acting in concert begins a tender or exchange offer, circulates a proxy to shareholders or takes other steps known to Employee to effect a
Liquidity Event, Employee agrees to remain an employee of ZS Pharma and to devote his or her best efforts to render full-time services to ZS Pharma commensurate with Employee’s position, until the earliest of the following: (a) such other
corporation, person or group has abandoned or terminated efforts to effect a Liquidity Event; (b) a Liquidity Event has occurred; or (c) this Agreement has been terminated. 

8. Notices. For purposes of this Agreement, notices and all other communications provided for in the Agreement shall be in
writing and shall be deemed to have been duly given when delivered personally, mailed by United States certified mail, return receipt requested, postage prepaid, or sent by prepaid express mail, addressed as follows: 

If to ZS Pharma: 

ZS Pharma, Inc. 

508 Wrangler Drive 

Suite 100 

Coppell, Texas 75019 

Attn.: Corporate Secretary 

If to Employee: 

To the address set forth on the last page of this Agreement. 

Either party may change the address to which notices are to be sent by written notice to the other party. Notice of change in notice address shall be
effective only upon receipt by the other party. 
 9. Successors; Binding Agreement. 

(a) ZS Pharma will require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all
or substantially all of the business and/or assets of ZS Pharma expressly to assume and agree to perform this Agreement in the same manner and to the same extent that ZS Pharma would be required to perform it if no such succession had taken place.

 (b) This Agreement shall inure to the benefit of and be enforceable by Employee’s personal or legal representatives,
executors, administrators, successors, heirs, distributees, devisees and legatees. 

  
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 10. Legal Actions.  

(a) This Agreement shall be governed by the laws of the State of Texas excluding any conflicts or choice of law rule or
principle that might otherwise refer construction or interpretation of this Agreement to the substantive law of another jurisdiction. 

(b) Any legal action seeking to enforce the terms of this Agreement, or based on any right arising out of this Agreement must
be brought in the appropriate court located in Tarrant County, Texas, or if jurisdiction will so permit, in the Federal District Court for the Northern District of Texas. ZS Pharma and Employee hereby consent to the jurisdiction over each of them by
such courts and waive all objections based on venue or inconvenient forum. 
 (c) In the event any legal action is brought at
any time to resolve a dispute under or in connection with this Agreement, ZS Pharma shall reimburse Employee, on a current basis, for all legal fees and expenses, if any, incurred by Employee in connection with such action. ZS Pharma shall make
those reimbursement payments to Employee within thirty (30) days after receiving Employee’s statement for such fees and expenses, along with reasonable supporting documentation. In the event, however, that ZS Pharma is the prevailing party
in the action under circumstances that permit the court to award attorney’s fees to ZS Pharma, Employee shall reimburse ZS Pharma for all sums advanced to Employee pursuant to this Section. 

11. Miscellaneous. 

(a) The invalidity or unenforceability of any provision of this Agreement shall not affect the validity or enforceability of
any other provision of this Agreement, which shall remain in full force and effect. 
 (b) No waiver by either party at any
time of any breach by the other party of, or compliance with, any condition or provision of this Agreement to be performed by such other party shall be deemed a waiver of similar or dissimilar provisions at the same or at any subsequent time. No
agreement or representations, oral or otherwise, express or implied, with respect to the subject matter of this Agreement have been made by either party which are not set forth expressly in this Agreement. 

(c) In no event shall the Employee be obligated to seek other employment or take any other action by way of mitigation of the
amounts payable to the Employee under any of the provisions of this Agreement, and such amounts shall not be reduced whether or not the Employee obtains other employment. 

12. Effective Date and Expiration. This Agreement becomes effective as of the Effective Date and will expire immediately
following the date on which Employee’s employment with ZS Pharma is terminated by ZS Pharma, by Employee, or by reason of Employee’s death or Disability. Expiration of this Agreement shall not reduce or eliminate the rights and duties that
Employee and ZS Pharma have accrued before expiration. 

  
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 13. Definitions. The following definitions shall be applicable to and govern the
interpretation of this Agreement: 
 (a) “Affiliate” means any entity that is a member, along with ZS Pharma, Inc.,
of a controlled group of corporations or a group of other trades or businesses under common control, within the meaning of Code Section 414(b) or (c). 

(b) “ZS Pharma” means ZS Pharma, Inc., an Affiliate, and any successor to the business or assets of ZS Pharma, Inc.
that executes and delivers the agreement provided for in Section 9(a) of this Agreement or which otherwise becomes bound by all of the terms and provisions of this Agreement by the operation of law. 

(c) “Board of Directors” means the Board of Directors of ZS Pharma. 

(d) “Cause” means, with respect to termination of Employee’s employment by ZS Pharma, one or more of the
following occurrences, as determined by the Board of Directors: (i) Employee’s willful and continued failure to perform substantially the duties of Employee’s position or to follow lawful instructions of a senior executive or the
Board of Directors, if such failure continues for a period of five days after ZS Pharma delivers to Employee a written notice identifying such failure; (ii) Employee’s conviction of a felony or of another crime that reflects adversely on
ZS Pharma; (iii) Employee’s engaging in fraudulent or dishonest conduct, gross misconduct that is injurious to ZS Pharma, or any misconduct that involves moral turpitude; (iv) Employee’s material breach of his or her obligations
under this Agreement or under the Employee Nondisclosure and Noncompete Agreement between Employee and ZS Pharma; (v) alcohol or substance abuse that has impaired or could reasonably be expected to impair the ability of Employee to perform his
or her duties to ZS Pharma; (vi) failure to comply with ZS Pharma’s policies in any material respect, including those regarding harassment or discrimination in employment; or (vii) excessive absenteeism, willful or
persistent neglect of, or abandonment of Employee’s duties (other than due to illness or any other physical condition that could reasonably be expected to result in Disability), which has not been cured after reasonable notice from
ZS Pharma. For any of the stated occurrences to constitute “Cause” under this Agreement, the Board of Directors must find that the stated act or omission occurred, by a resolution duly adopted by the affirmative vote of at least
three-quarters of the entire membership of the Board of Directors, after giving reasonable notice to Employee and an opportunity for Employee, together with Employee’s counsel, to be heard before the Board of Directors. 

(e) “Code” means the Internal Revenue Code of 1986, as amended. 

(f) “Confidential Information” means any and all financial, commercial, business, technical, engineering, or other
information in written, oral, visual, or electronic form concerning the business and affairs of ZS Pharma and its affiliates, agents, and employees, including without limitation (i) information derived from reports, investigations, experiments,
research, and work in progress, (ii) drawings, designs, plans, and proposals, (iii) manufacturing methods, (iv) proprietary computer 

  
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programs and codes, (v) marketing and sales data, plans, and proposals, (vi) customer, distributor, licensee, and supplier lists and any other information about ZS Pharma’s
relationships with others, (vii) historical financial information and financial projections, and (viii) all other concepts, ideas, materials, and information prepared or provided by or for ZS Pharma. The term “Confidential
Information” does not include information that: (a) was or is made available to Employee without restriction by a third party who has the right to disclose such information to Employee; (b) was known to or independently developed by
Employee prior to beginning employment by ZS Pharma, as evidenced by corroborating, dated written documentation created prior to beginning employment by ZS Pharma; or (c) becomes public through no breach of this Agreement by Employee. In any
action, suite, or other legal or administrative proceeding involving an alleged breach of this Agreement, Employee will bear the burden of proving that the relevant information falls within one of these excluded categories. 

(g) “Deemed Liquidation Event” means either of the following events unless the holders of a majority of the
outstanding shares of ZS Pharma Preferred Stock, including the consent of the holders of 66 2/3% of the then outstanding shares of ZS Pharma Series C Preferred Stock, voting together as a single class on an as-converted basis, elect otherwise by
written notice sent to ZS Pharma at least five (5) business days prior to the effective date of any such event: 
 (1)
a merger or consolidation in which ZS Pharma is a constituent party, or in which a subsidiary of ZS Pharma is a constituent party and ZS Pharma issues shares of its capital stock pursuant to such merger or consolidation, except any such merger or
consolidation involving ZS Pharma or a subsidiary in which the shares of capital stock of ZS Pharma outstanding immediately prior to such merger or consolidation continue to represent, or are converted into or exchanged for shares of capital stock
that represent, immediately following such merger or consolidation, at least a majority, by voting power, of the capital stock of (i) the surviving or resulting corporation or (ii) if the surviving or resulting corporation is a wholly
owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or resulting corporation (provided that all shares of ZS Pharma Common Stock issuable upon exercise of
options outstanding immediately prior to such merger or consolidation or upon conversion of convertible securities outstanding immediately prior to such merger or consolidation and, if applicable, converted or exchanged in such merger or
consolidation on the same terms as the actual outstanding shares of Common Stock are converted or exchanged), or 
 (2) the
sale, lease, transfer, exclusive license or other disposition, in a single transaction or series of related transactions, by ZS Pharma or any subsidiary of ZS Pharma or all or substantially all of the assets of ZS Pharma and its subsidiaries taken
as a whole, or the sale or disposition (whether by merger or otherwise) of one or more subsidiaries of ZS Pharma if substantially all of the assets of ZS Pharma and its subsidiaries taken as a whole are held by such subsidiary or subsidiaries,
except where such sale, lease, transfer, exclusive license or other disposition is to a wholly owned subsidiary of ZS Pharma. 

  
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 (h) “Deferred Compensation” means compensation provided under a
nonqualified deferred compensation plan as defined in, and subject to, Code Section 409A. 
 (i) “Disability”
or “Disabled” means, with respect to Employee, when Employee is unable to perform the essential functions of his or her job, with or without reasonable accommodation in accordance with the Americans with Disabilities Act, as determined by
the Board in its good faith judgment for (i) a period of 120 consecutive days or (ii) shorter periods aggregating 150 days during any 12-month period. 

(j) “Effective Date” means
                    . 

(k) “Good Reason” means, with respect to the termination of employment by Employee, one or more of the following
occurrences: (i) a material adverse change in the nature or scope of Employee’s responsibilities; (ii) a reduction in Employee’s salary rate or target bonus; (iii) a reduction of ten percent (10%) or more in the
aggregate benefits provided to Employee and his or her dependents under ZS Pharma’s employee benefit plans; or (iv) failure by ZS Pharma to obtain the assumption agreement from any successor as contemplated in Section 9(a). 

(l) “Liquidity Event” means either a Deemed Liquidation Event or a Qualified IPO. 

(m) “Notice of Termination” means a written notice, from the party initiating Employee’s employment termination
to the other party, specifying whether the termination is covered by the provisions of Section 4(a) or (b) and the facts and circumstances claimed to provide the basis for termination. 

(n) “Option Agreement” means any agreement or other instrument evidencing a grant or award of stock options under the
Stock Option Plan. 
 (o) “Qualified IPO” means the closing of the sale of shares of ZS Pharma Common Stock to the
public at a price of at least $13 per share (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the ZS Pharma Common Stock), in a firm-commitment
underwritten public offering, pursuant to an effective registration statement under the Securities Act of 1933, as amended, resulting in at least $30 Million of gross proceeds to ZS Pharma. 

(p) “Stock Option Plan” means the ZS Pharma, Inc. 2008 Stock Incentive Plan, as amended. 

(q) “Termination Date” means the date on which Employee’s employment with ZS Pharma is terminated
(i) pursuant to Employee’s Notice of Termination to ZS Pharma, ZS Pharma’s Notice of Termination to Employee, or (ii) by reason of Employee’s death. 

  
 13 

 ZS Pharma, by its duly authorized officers, and Employee have caused to be executed and executed,
respectively, this Agreement as of the Effective Date. 
  

					
	ZS Pharma, Inc.	 		  	EMPLOYEE
			
	 By:
	 		  	  

	Name:	 		  	Name:
	Title:	 		  	Address:

 EXHIBIT A 

Employee Third Party Confidentiality Agreements 

Exhibit AEX-10.10

 Exhibit 10.10 

ZS PHARMA, INC. 

FORM OF INVENTION ASSIGNMENT 

AND CONFIDENTIALITY AGREEMENT 

This Invention Assignment and Confidentiality Agreement (“Agreement”) is entered into as of the date of the last signature
below and shall be effective as of                                 ,
20    , by and between ZS Pharma, Inc., having an address of 508 Wrangler Drive, Suite 100, Coppell, Texas, 75019, its subsidiaries, affiliates, successors or assigns (together the “Company”), and
                                , an individual having an address of
                                (“Employee”). 

WHEREAS, Company wishes to continue to employ Employee, and Employee desires to continue employment by the Company; 

WHEREAS, Employee has been an employee of and has continuously been employed by Company since
            ; 
 WHEREAS, Employee acknowledges and agrees that the Company may
provide Employee with Confidential Information, subject to and in consideration of the Agreement; 
 WHEREAS, Company believes, and Employee
acknowledges and agrees, that the Confidential Information of Company is extremely important to the operations and success of the Company; 

WHEREAS, Employee acknowledges and agrees that Employee during the course of Employee’s employment with Company, Employee has or will
make, conceive of, or reduce to practice inventions, original works of authorship, developments, concepts, improvements, designs, discoveries, ideas, trademarks, or trade secrets. 

NOW THEREFORE, as a condition of Employee’s continued employment with Company and in consideration of Employee’s continued
employment with Company and Employee’s receipt of the compensation hereafter paid to Employee by Company, Employee agrees to the following provisions of this Invention Assignment and Confidentiality Agreement (this
“Agreement”): 
 1. Confidential Information. 

A. Company Information. Employee agrees that during and after Employee’s employment with the Company, Employee will hold in the
strictest confidence, and will not use (except for the benefit of the Company during Employee’s employment) or disclose to any person, firm, or corporation (without written authorization of the President or the Board of Directors of the
Company) any Company Confidential Information. Employee understands that Employee’s unauthorized use or disclosure of Company Confidential Information during Employee’s employment may lead to disciplinary action, up to and including
immediate termination and legal 

 
action by the Company. Employee understands that “Company Confidential Information” means any and all non-public financial, commercial, business, technical, engineering, or other
information in written, oral, visual, or electronic form concerning the actual or anticipated business, research, development, or other affairs of the Company, including, without limitation, the Company’s technical data, trade secrets, or
know-how, including, but not limited to, research, product plans, or other information regarding the Company’s products or services and markets therefor, customer lists and customers (including, but not limited to, customers of the Company on
which Employee called or with which Employee may become acquainted during the term of Employee’s employment), software, developments, inventions, processes, formulas, technology, designs, drawings, engineering, hardware configuration
information, marketing, finances, and other business information. Company Confidential Information does not include any of the foregoing items to the extent that the same was or is: (a) made available to Employee without restriction by a third
party who has the right to disclose such information to Employee; (b) was known to or independently developed by Employee prior to beginning employment by the Company, as evidenced by corroborating, dated written documentation created prior to
beginning employment by the Company; or (c) publicly known and made generally available through no wrongful act of Employee or of others. Employee understands that nothing in this Agreement is intended to limit employees’ rights to discuss
the terms, wages, and working conditions of their employment, as protected by applicable law. 
 B. Former Employer Information.
Employee agrees that during Employee’s employment with the Company, Employee will not improperly use, disclose, or induce the Company to use any proprietary information or trade secrets of any former or concurrent employer or other person or
entity. Employee further agrees that Employee will not bring onto the premises of the Company or transfer onto the Company’s technology systems any unpublished document, proprietary information, or trade secrets belonging to any such employer,
person, or entity unless consented to in writing by both the Company and such employer, person, or entity. 
 C. Non-Disclosure of Third
Party Information. Employee recognizes that the Company may have received and in the future may receive from third parties associated with the Company, e.g., the Company’s customers, suppliers, licensors, licensees, partners, or
collaborators (“Associated Third Parties”), their confidential or proprietary information (“Associated Third Party Confidential Information”). By way of example, Associated Third Party Confidential Information may
include the habits or practices of Associated Third Parties, the technology of Associated Third Parties, requirements of Associated Third Parties, and information related to the business conducted between the Company and such Associated Third
Parties. Employee agrees at all times during Employee’s employment with the Company and thereafter to hold in the strictest confidence, and not to use or to disclose to any person, firm, or corporation, any Associated Third Party Confidential
Information, except as necessary in carrying out Employee’s work for the Company consistent with the Company’s agreement with such Associated Third Parties. Employee further agrees to comply with any and all Company policies and guidelines
that may be adopted from time to time regarding Associated Third Parties and Associated Third Party Confidential Information. Employee understands that Employee’s unauthorized use or disclosure of Associated

  
 -2- 

 
Third Party Confidential Information or violation of any Company policies during Employee’s employment will lead to disciplinary action, up to and including immediate termination and legal
action by the Company. 
 D. Return of Confidential Information and Other Documents. Upon separation from employment with the Company
or on demand by the Company during Employee’s employment, Employee will immediately deliver to the Company, and will not keep in Employee’s possession, recreate, or deliver to anyone else, any and all Company property, including, but
not limited to, Company Confidential Information, Associated Third Party Confidential Information, as well as all devices and equipment belonging to the Company (including computers, handheld electronic devices, telephone equipment, and other
electronic devices), Company credit cards, records, data, notes, notebooks, reports, files, proposals, lists, correspondence, specifications, drawings, blueprints, sketches, materials, photographs, charts, any other documents and property, and
reproductions of any and all of the aforementioned items that were developed pursuant to Employee’s employment with the Company, obtained in connection with Employee’s employment with the Company, or otherwise belonging to the Company, its
successors, or assigns. 
 E. Subpoena or Court Order. In the event Employee becomes aware of any proceeding that might result in
becoming legally compelled (by deposition, interrogatory, request for documents, subpoena, court order, or similar process) to disclose any Company or Associated Third Party Confidential Information, Employee shall promptly notify the Company of
such proceeding so that the Company may seek a protective order or other appropriate remedy or waive compliance with the terms of this Agreement with respect to such Confidential Information. In the event that Employee becomes legally compelled to
disclose any such Confidential Information and such protective order or other remedy is not obtained, or that the Company waives compliance with the provisions hereof, Employee agrees to disclose only that portion of such Confidential Information
that Employee is legally required to disclose. 
 2. Intellectual Property. 

A. Intellectual Property Retained and Licensed. Employee has attached hereto as Exhibit A, a list describing all
inventions, discoveries, original works of authorship, developments, improvements, and trade secrets that were conceived in whole or in part prior to Employee’s employment with the Company and to which Employee has any right, title, or
interest, and which relate to the Company’s proposed business, products, or research and development (“Prior Intellectual Property”); or, if no such list is attached, Employee represents and warrants that there is no such Prior
Intellectual Property. Furthermore, Employee represents and warrants that if any Prior Intellectual Property is included on Exhibit A, they will not materially affect Employee’s ability to perform all obligations under this Agreement.
If, in the course of Employee’s employment with the Company, Employee incorporates into or use in connection with any product, process, service, technology, or other work by or on behalf of the Company any Prior Intellectual Property, Employee
hereby grants to the Company a non-exclusive, royalty-free, fully paid-up, irrevocable, perpetual, worldwide license, with the right to grant and authorize sublicenses, to make, have made, modify, use, import, offer for sale, and sell such Prior
Intellectual Property as part of or in 

  
 -3- 

 
connection with such product, process, service, technology, or other work, and to practice any method related thereto. 

B. Assignment of Intellectual Property. Employee agrees that Employee will promptly make full written disclosure to the Company, will
hold in trust for the sole right and benefit of the Company, and to and does hereby irrevocably assign to the Company, or its designee, all Employee’s right, title, and interest in and to any and all inventions, original works of authorship,
developments, concepts, improvements, designs, discoveries, ideas, processes, designs, methods, substances, articles, computer programs, derivative works, trademarks, or trade secrets, whether or not patentable or registrable under patent,
copyright, or similar laws, which Employee has solely or jointly conceived, invented, discovered, created, developed or reduced to practice, or caused to be conceived, invented, discovered, created, developed or reduced to practice, during the
period of time Employee has been in the employ of the Company (including during Employee’s off-duty hours), or with the use of Company’s equipment, supplies, facilities, or Company Confidential Information, or which Employee may solely or
jointly conceive, invent, discover, create, develop or reduce to practice, or conceive, invent, discover, create, develop or reduce to practice, during the period of time Employee is in the employ of the Company (including during Employee’s
off-duty hours), or with the use of Company’s equipment, supplies, facilities, or Company Confidential Information (collectively referred to as “Intellectual Property”). Employee further acknowledges that all original works of
authorship that are or have been made (solely or jointly with others) within the scope of and during the period of Employee’s employment with the Company and that are protectable by copyright are “works made for hire,” as that term is
defined in the United States Copyright Act. Employee hereby irrevocably relinquishes and forever waives for the benefit of the Company any moral rights (defined as either any right to claim authorship of a work or any right to object to any
distortion or other modification of a work, or any similar right existing under the law of any country in the world or under any international agreement) in any original work of authorship. Employee understands and agrees that the decision whether
or not to commercialize or market any Intellectual Property is within the Company’s sole discretion and for the Company’s sole benefit, and that no royalty or other consideration will be due as a result of the Company’s efforts to
commercialize or market any such Intellectual Property. 
 C. Patent and Copyright Registrations. Employee agrees to and shall assist
the Company, or its designee, at the Company’s expense, in every proper way to secure the Company’s rights in the Inventions and any rights relating thereto in any and all countries, including the disclosure to the Company of all pertinent
information and data with respect thereto, the execution of all applications, specifications, oaths, assignments, and all other instruments that the Company shall deem proper or necessary in order to apply for, register, obtain, maintain, defend,
and enforce such rights, and in order to assign and convey to the Company, its successors, assigns, and nominees the sole and exclusive rights, title, and interest in and to such Inventions and any rights relating thereto, and cooperating in all
respects with including, but not limited to, testifying in a suit or other proceeding relating to such Inventions and any rights relating thereto. Employee further agrees that Employee’s obligations under this paragraph shall continue after the
termination of this Agreement. If the Company is unable because of Employee’s mental or physical incapacity or for any other 

  
 -4- 

 
reason to secure Employee’s signature with respect to any Inventions, including, without limitation, to apply for or to pursue any application for any United States or foreign patents or
copyright registrations covering such Inventions, then Employee hereby irrevocably designates and appoints Company and its duly authorized officers and agents as Employee’s agent and attorney in fact, to act for and in Employee’s behalf
and stead, to execute, deliver and file any and all papers and oaths, and to do all other lawfully permitted acts with respect to such Inventions with the same legal force and effect as if executed by Employee. 

D. Maintenance of Records. Employee agrees to and shall keep and maintain adequate, current, accurate, and authentic written records of
all Inventions made (solely or jointly with others) during the term of Employee’s employment with the Company. The records will be in the form of notes, sketches, drawings, electronic files, memoranda, reports, or any other format that may be
specified by the Company. Employee agrees to and shall promptly submit such records to Company. The records are and will be available to and remain the sole property of the Company at all times. 

Employee shall perform Employee’s obligations under this Section 2 at the Company’s expense, without any additional
compensation other than that which Employee receives by reason of Employee’s employment with the Company, or pursuant to a separate agreement between the Company and Employee, if any, of the Company that may be in effect from time to time. 

3. Cooperation. During the period of Employee’s employment with the Company and for a period of three years thereafter,
Employee shall, upon reasonable notice, furnish such information and assistance to Company as may reasonably be required by Company in connection with any audit, investigation, litigation or other action to which Company, or any of its affiliates,
agents, or employees is or may become subject. Assistance includes being reasonably available for interviews with counsel for Company. Company shall reimburse Employee for all reasonable out-of-pocket expenses incurred by Employee in rendering such
assistance. 
 4. Certain Remedies. In recognition of the fact that a breach by Employee of any of the provisions of
this Agreement will cause irreparable damage to Company for which monetary damages alone will not constitute an adequate remedy, Company shall be entitled as a matter of right (without being required to prove damages or furnish any bond or other
security) to obtain a restraining order, an injunction, an order of specific performance, or other equitable or extraordinary relief from any court of competent jurisdiction restraining any further violation of such provisions by Employee or
requiring Employee to perform Employee’s obligations hereunder. Such right to equitable or extraordinary relief shall not be exclusive but shall be in addition to all other rights and remedies to which the Company may be entitled at law or in
equity, including without limitation the right to recover monetary damages for the breach of any provision of this Agreement. 

  
 -5- 

 5. General Provisions. 

A. Term of this Agreement. Except as otherwise expressly provided herein with respect to certain provisions hereof, this
Agreement shall continue in effect and survive for an indefinite period notwithstanding the termination of Employee’s employment with the Company for any reason. This Agreement is not, however, and shall not be deemed to be, an employment
agreement that obligates the Company to employ Employee, or obligates Employee to continue in the Company’s employment, for any term whatsoever. Employee acknowledges and agrees that Employee is an employee “at will” and can be
terminated by the Company at any time in its sole discretion, with or without cause, and with or without advance notice. 
 B. No
Offset. The representations and covenants contained in this Agreement on the part of Employee shall be construed as ancillary to and independent to any other component of the employment relationship between the Company and Employee, and the
existence of any claim (monetary or otherwise) or cause of action of Employee against the Company or any officer, director or shareholder of the Company shall not constitute a defense to the enforcement by the Company of the covenants of Employee
contained in this Agreement. 
 C. Extension of Duration; Survival. If Employee violates any covenant contained in this
Agreement, the Company shall not, as a result of such violation or the time involved in obtaining legal or equitable relief therefor, be deprived of the benefit of the full period of any such covenant. Accordingly, the covenants of Employee
contained in this Agreement shall be deemed to have the duration specified in this Agreement which period shall be extended by a number of days equal to the sum of (i) the total number of days Employee is in violation of any of the covenants
contained in this Agreement prior to the commencement of any litigation, through the date of entry by a court of competent jurisdiction of a final judgment enforcing the covenants of Employee in this Agreement. 

D. Severability. If any provision of this Agreement is held to be unenforceable by reason of being vague or unreasonable as to area,
duration, or scope of activity or otherwise, this Agreement will be considered divisible and inoperative as to such provision to the extent that such provision is unenforceable, with this Agreement to remain in full force and effect in all other
respects. If any provision of this Agreement, although unenforceable as written, may be made enforceable by limitation or reformation thereof, then such provision will be enforceable to the maximum extent permitted by applicable law. 

E. APPLICABLE LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF TEXAS, EXCLUDING ANY
CHOICE OF LAW RULES WHERE SUCH RULES WOULD CAUSE THE LAW OF ANOTHER JURISDICTION TO APPLY. 
 F. Notices. Any notice or other
communication required or permitted under this Agreement shall be sufficiently given if such notice is in writing and delivered in person or sent by registered or certified mail, postage prepaid, to the address specified for each party on the
initial page hereof. 
 G. Successors and Assigns; Entire Agreement; Amendment; No Waiver; Headings; Counterparts. This
Agreement shall be binding upon and inure to the benefit of the 

  
 -6- 

 
parties hereto and their respective successors and permitted assigns; provided, however, Employee may not assign this Agreement or any interest herein to any other person or entity without the
prior written consent of the Company, which consent may be given or withheld in its sole discretion. This Agreement represents the entire understanding and agreement of the Parties hereto with respect to the subject matter hereof and may be
modified, amended or waived only by a separate agreement or writing signed by the Parties expressly so modifying, amending or waiving this Agreement. No failure or delay by any Party hereto in exercising any right, power, remedy or privilege
hereunder shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, remedy, power, or privilege. The descriptive headings contained in this
Agreement are for convenience only and shall not affect the construction or interpretation of this Agreement. This Agreement may be signed in one or more counterparts, all of which shall constitute one and the same agreement. 

 

									
					
	Date:	 	 	 		 		 	 
		 		 		 		 	Signature
					
		 		 		 		 	 
		 		 		 		 	Name of Employee (typed or printed)
		 		 		 		 	
				
	Witness:	 		 		 	
		 		 		 	
	 	 		 		 	
	Signature	 		 		 	
				
		 		 		 	
	 	 		 		 	
	Name (typed or printed)	 		 		 	

  
 -7- 

 Exhibit A 

LIST OF PRIOR INVENTIONS 

AND ORIGINAL WORKS OF AUTHORSHIP 
  

					
	
                Title       
         
	 	
                    Date 
                   
	 	 Identifying Number or Brief
Description

            No inventions or improvements 

            Additional Sheets Attached 

 

			
		
	Signature of Employee:	 	 
		
	Print Name of Employee:	 	 

			
		
	Date:	 	 

initials                      
   

  
 -8-

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