Document:

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                                                                    EXHIBIT 4.01

                          REGISTRATION RIGHTS AGREEMENT

      This Registration Rights Agreement (this "AGREEMENT") is made and entered
into as of December 23, 2004 by and between Flextronics International Ltd., a
Singapore company ("FLEXTRONICS"), and the individuals and entities listed on
Exhibit A attached hereto who execute one or more counterpart signature pages to
this Agreement (the "HOLDERS").

                                    RECITALS

      A. This Agreement is entered into pursuant to that certain Amended and
Restated Agreement and Plan of Reorganization dated as of December 23, 2004 (the
"MERGER AGREEMENT") by and among Flextronics, PIC Acquisition Corporation, a
California corporation and a direct wholly-owned subsidiary of Flextronics
("MERGER SUB"), and Peripheral Imaging Corporation, a California corporation
(the "COMPANY").

      B. The Merger Agreement provides that, subject to the terms and conditions
of the Merger Agreement, Merger Sub will be merged with and into the Company in
a statutory merger, with the Company as the surviving corporation in the merger
(the "MERGER") in which all of the outstanding shares of common stock of the
Company will be converted into the right to receive ordinary shares, S$0.01 par
value per share, of Flextronics (the "FLEXTRONICS ORDINARY SHARES").

      C. As an inducement for the Holders to approve the Merger Agreement, the
Merger and the transactions contemplated by the Merger Agreement, Flextronics
desires to grant the registration rights to the Holders as contained herein.

      NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
promises hereinafter set forth, the parties hereto agree as follows:

      1. DEFINITIONS AND REFERENCES.

      Unless otherwise defined herein, the capitalized terms in this Agreement
have the same meanings given to them in the Merger Agreement. For purposes of
this Agreement, in addition to the definitions set forth elsewhere herein or in
the Merger Agreement, the following terms shall have the following respective
meanings:

      "AFFILIATE" of a Holder shall mean a person who controls, is controlled by
or is under common control with such Holder, or the spouse or children (or a
trust exclusively for the benefit of a spouse and/or children) of such Holder.

      "REGISTER," "REGISTERED" and "REGISTRATION" shall refer to a registration
effected by preparing and filing a Registration Statement or similar document in
compliance with the United States Securities Act of 1933, as amended (the "1933
ACT"), and the declaration or ordering of effectiveness of such Registration
Statement or document by the United States Securities and Exchange Commission
(the "SEC").

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      "REGISTRABLE STOCK" shall mean (a) the Flextronics Ordinary Shares issued
to a Holder pursuant to the Merger Agreement; and (b) any Flextronics Ordinary
Shares issued as (or issuable upon the conversion or exercise of any warrant,
right, option or other convertible security which is issued as) a dividend or
other distribution with respect to, or in exchange for, or in replacement of,
such Flextronics Ordinary Shares. For purposes of this Agreement, any
Registrable Stock shall cease to be Registrable Stock when (x) a Registration
Statement covering such Registrable Stock has been declared effective and such
Registrable Stock has been disposed of pursuant to such effective Registration
Statement, or (y) such Registrable Stock is sold by a person in a transaction
that is exempt from registration pursuant to Rule 144 under the 1933 Act or a
transaction in which the Holders' rights under this Agreement are not assigned
in accordance with Section 6 of this Agreement. In addition, the Registrable
Stock held by any Holder shall cease to be Registrable Stock on such date on
which all of the Registrable Stock held by such Holder can be sold within a
period of three months pursuant to Rule 144 promulgated under the 1933 Act (or
any similar provision then in force).

      2. "SHELF" REGISTRATION.

            (a) As soon as practicable following the Effective Time of the
Merger, Flextronics shall use commercially reasonable efforts to file with the
SEC within five (5) business days after the Effective Time of the Merger a
"shelf" registration statement on Form S-3 in the format required by the SEC
with all required exhibits pursuant to Rule 415(a)(1) under the 1933 Act (the
"REGISTRATION STATEMENT") for the public resale on a continuous or delayed basis
by the Holders of the Registrable Stock, and shall use all commercially
reasonable efforts to cause the Registration Statement to be declared effective
under the 1933 Act as promptly as possible after the filing thereof, where
"commercially reasonable efforts" involves a level of effort in which
Flextronics proactively and diligently undertakes its obligations hereunder
without any unnecessary material delays or deviations. The plan of distribution
indicated in the Registration Statement will include all such transactions as
the Holders may reasonably request in writing prior to the filing of the
Registration Statement and that can be included in the Registration Statement
under the rules and regulations of the SEC. Flextronics shall use all reasonable
efforts to keep the Registration Statement continuously effective under the 1933
Act until the earlier of (x) the date which is two (2) years after the date
hereof and (y) the date when all Registrable Stock covered by such Registration
Statement has been sold or may be sold pursuant to Rule 144 promulgated under
the 1933 Act (or any similar provision then in force) without application of the
volume limitations under Rule. The Holders will only offer and sell Registrable
Stock in a transaction that is covered by the plan of distribution indicated in
the Registration Statement or is exempt from registration under the 1933 Act.

            (b) Subject to Flextronics's compliance with subsection (a) of this
Section 2, the parties hereby acknowledge that Flextronics shall not have any
liability under this Agreement to any person in the event that any Form S-3 is
not declared effective by the SEC.

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      3. OBLIGATIONS OF FLEXTRONICS. Flextronics shall:

            (a) prepare and file with the SEC such amendments and supplements to
the Registration Statement and the prospectus used in connection therewith as
may be necessary to keep the Registration Statement effective and to comply with
the provisions of the 1933 Act with respect to the disposition of all
Registrable Stock covered by the Registration Statement for the period required
to effect the distribution of the Registrable Stock as set forth in Section 2;

            (b) use all reasonable efforts to register or qualify the
Registrable Stock covered by the Registration Statement under the securities or
Blue Sky laws of such jurisdiction within the United States and Puerto Rico as
shall be reasonably requested by the Holders for the distribution of the
Registrable Stock covered by the Registration Statement; provided, however, that
Flextronics shall not be required in connection therewith or as a condition
thereto to qualify to do business in or to file a general consent to service of
process in any jurisdiction wherein it would not but for the requirements of
this paragraph (b) be obligated to do so; and provided, further, that with
respect to Registrable Stock held by any Holder, Flextronics shall not be
required to qualify such Registrable Stock in any jurisdiction in which the
securities regulatory authority requires that such Holder submit any of his or
her Registrable Stock to the terms, provisions and restrictions of any escrow,
lockup or similar agreement(s) for consent to sell Registrable Stock in such
jurisdiction unless such Holder agrees to do so;

            (c) promptly notify the Holders at any time when a prospectus
relating thereto is required to be delivered under the 1933 Act of the happening
of any event as a result of which the prospectus included in the Registration
Statement, as then in effect, includes an untrue statement of a material fact or
omits to state any material fact required to be stated therein or necessary to
make the statements therein not misleading in light of the circumstances under
which they were made and, at the request of any Holder, promptly prepare and
furnish to such Holder a reasonable number of copies of a supplement to or an
amendment of such prospectus, or a revised prospectus, as may be necessary so
that, as thereafter delivered to the purchasers of such securities, such
prospectus shall not include an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading in light of the circumstances under which they
were made; provided, that in the event of a material development or transaction
affecting Flextronics that has not yet been publicly disclosed, if Flextronics
shall furnish to the Holders a written notice executed by a duly authorized
officer of Flextronics (such notice being referred to herein as a "DEFERRAL
NOTICE") that Flextronics has determined in good faith that it would be
adversely affected by such disclosure, Flextronics may defer preparing and
furnishing such supplement or amendment for a period of not more than sixty (60)
consecutive days (and not more than 90 days in any year), at which time it shall
so notify the Holders ("SECOND NOTICE") and shall prepare and furnish to the
Holders any such supplement or amendment as may then be required. Following
receipt of any supplement or amendment to any prospectus, the Holders shall
deliver such amended, supplemental or revised prospectus in connection with any
offers or sales of Registrable Stock, and shall not deliver or use any
prospectus not so amended, supplemented or revised. Following receipt of a
Deferral Notice, the Holders shall not make any further sales of Registrable
Stock pursuant to the Registration Statement until the Holders receive the
Second Notice, and any such amendment or supplement, from Flextronics;

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            (d) Furnish to the Holders such numbers of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the
1933 Act, and such other documents as they may reasonably request in order to
facilitate the disposition of Registrable Stock owned by them; and

            (e) Cause all such Registrable Stock registered pursuant hereunder
to be listed on each securities exchange on which similar securities issued by
Flextronics are then listed.

      4. FURNISH INFORMATION. It shall be a condition precedent to the
obligations of Flextronics to take any action pursuant to this Agreement that
each Holder shall furnish to Flextronics such information regarding itself, the
Registrable Stock held by it, and the intended method of disposition of such
securities as Flextronics shall reasonably request and as shall be required in
connection with the actions to be taken by Flextronics hereunder.

      5. EXPENSES. Flextronics and the Company will share equally any filing
fees incurred in connection with the registration pursuant to this Agreement.
All other expenses incurred in connection with the registration pursuant to this
Agreement, excluding underwriters' or brokers' discounts and commissions, but
including, without limitation, word processing, duplicating, printers' and
accounting fees, listing fees, messenger and delivery expenses, all fees and
expenses of complying with state securities or Blue Sky laws, and the fees and
disbursements of counsel for Flextronics, shall be paid by Flextronics. Each
Holder shall bear and pay the underwriting discounts and commissions and
brokerage fees applicable to the sale of securities offered for his or her
account in connection with any registrations, filings and qualifications made
pursuant to this Agreement and the fees and disbursements of any counsel for
such Holder.

      6. TRANSFER OF REGISTRATION RIGHTS. The registration rights of a Holder
under this Agreement with respect to any Registrable Stock may be transferred or
assigned to (a) any transferee or assignee of such Registrable Stock who, after
such transfer or assignment, holds at least five thousand (5,000) shares of
Registrable Stock previously held by such Holder or (b) an Affiliate of such
Holder; provided, however, that (i) such Holder shall give Flextronics written
notice prior to the time of such transfer stating the name and address of the
transferee and identifying the securities with respect to which the rights under
this Agreement are being transferred; (ii) such transferee shall agree in
writing, in form and substance reasonably satisfactory to Flextronics, to be
bound as a Holder by the provisions of this Agreement; and (iii) immediately
following such transfer the further disposition of such securities by such
transferee is restricted under the 1933 Act.

      7. INDEMNIFICATION. In the event any Registrable Stock is included in a
Registration Statement under this Agreement:

            (a) Flextronics shall indemnify and hold harmless each Holder, such
Holder's directors and officers, each person who participates in the offering of
such Registrable Stock, including underwriters (as defined in the 1933 Act), and
each person, if any, who controls such Holder or participating person within the
meaning of the 1933 Act, against any losses, claims, damages or liabilities,
joint or several, to which they may become subject under the 1933 Act or
otherwise, insofar as such losses, claims, damages or liabilities (or
proceedings in respect

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thereof) arise out of or are based upon any untrue or alleged untrue statement
of any material fact contained in the Registration Statement on the effective
date thereof (including any prospectus filed under Rule 424 under the 1933 Act
or any amendments or supplements thereto) or arise out of or are based upon the
omission or alleged omission to state therein a material fact required to be
stated therein or necessary to make the statements therein not misleading, and
shall reimburse each such Holder, such Holder's directors and officers, and such
participating person or controlling person for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 7(a) shall not apply to amounts
paid in settlement of any such loss, claim, damage, liability or action if such
settlement is effected without the consent of Flextronics; provided, further,
that Flextronics shall not be liable to any Holder, such Holder's directors and
officers, participating person or controlling person in any such case for any
such loss, claim, damage, liability or action to the extent that it arises out
of or is based upon an untrue statement or alleged untrue statement or omission
or alleged omission made in connection with the Registration Statement,
preliminary or final prospectus, or amendments or supplements thereto, in
reliance upon and in conformity with written information furnished by or on
behalf of any such Holder, such Holder's directors and officers, participating
person or controlling person expressly for use in connection with such
registration; provided, further, that Flextronics shall not be liable to any
Holder, such Holder's directors and officers, participating person or
controlling person in any such case for any such loss, claim, damage, liability
or action to the extent that it arises out of or is based upon an offer or sale
by such Holder in violation of any of such Holder's obligations under Section
3(c). Such indemnity shall remain in full force and effect regardless of any
investigation made by or on behalf of any such Holder, such Holder's directors
and officers, participating person or controlling person, and shall survive the
transfer of such securities by such Holder and any termination of this
Agreement.

            (b) Each Holder severally and not jointly shall indemnify and hold
harmless Flextronics, each of its directors and officers, each person, if any,
who controls Flextronics within the meaning of the 1933 Act, and each agent and
any underwriter for Flextronics (within the meaning of the 1933 Act) against any
losses, claims, damages or liabilities, joint or several, to which Flextronics
or any such director, officer, controlling person, agent or underwriter may
become subject under the 1933 Act or otherwise, insofar as such losses, claims,
damages or liabilities (or proceedings in respect thereof) that arise out of or
are based upon any untrue or alleged untrue statement of any material fact
contained in the Registration Statement (including any prospectus filed under
Rule 424 under the 1933 Act or any amendments or supplements thereto) or arise
out of or are based upon the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading, in each case to the extent, but only to the extent, that
such untrue statement or alleged untrue statement or omission or alleged
omission was made in the Registration Statement, preliminary or final
prospectus, or amendments or supplements thereto, in reliance upon and in
conformity with written information furnished by or on behalf of such Holder
expressly for use in connection with such registration; and each such Holder
shall reimburse any legal or other expenses reasonably incurred by Flextronics
or any such director, officer, controlling person, agent or underwriter in
connection with investigating or defending any such loss, claim, damage,
liability or action; provided, however, that the indemnity agreement contained
in this Section 7(b) shall not apply to amounts paid in settlement of any such
loss, claim, damage, liability or action if such settlement is effected without
the consent of such

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Holder; provided, further, that the liability of each Holder hereunder shall be
limited to the proportion of any such loss, claim, damage, liability or expense
which is equal to the proportion that the net proceeds from the sale of the
shares sold by such Holder under such Registration Statement bears to the total
net proceeds from the sale of all securities sold thereunder, but not in any
event to exceed the net proceeds received by such Holder from the sale of
Registrable Stock covered by such Registration Statement.

            (c) Promptly after receipt by an indemnified party under this
Section 7 of notice of the commencement of any action, such indemnified party
shall, if a claim in respect thereof is to be made against any indemnifying
party under this Section 7, notify the indemnifying party in writing of the
commencement thereof and the indemnifying party shall have the right to
participate in and assume the defense thereof with counsel selected by the
indemnifying party and reasonably satisfactory to the indemnified party;
provided, however, that an indemnified party shall have the right to retain its
own counsel, with all fees and expenses thereof to be paid by the indemnifying
party (if representation of such indemnified party by the counsel retained by
the indemnifying party would be inappropriate due to actual or potential
differing interests between such indemnified party and any other party
represented by such counsel in such proceeding), and to be apprised of all
progress in any proceeding the defense of which has been assumed by the
indemnifying party. The failure to notify an indemnifying party promptly of the
commencement of any such action, if and to the extent prejudicial to its ability
to defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 7, but the omission so to notify the
indemnifying party will not relieve it of any liability that it may have to any
indemnified party otherwise than under this Section 7.

            (d) To the extent any indemnification by an indemnifying party is
prohibited or limited by law, the indemnifying party, in lieu of indemnifying
such indemnified party, shall contribute to the amount paid or payable by such
indemnified party as a result of such losses, claims, damages or liabilities in
such proportion as is appropriate to reflect the relative fault of the
indemnifying party and indemnified party in connection with the actions which
resulted in such losses, claims, damages or liabilities, as well as any other
relevant equitable considerations, provided that in no event shall any
contribution by a Holder under this Section 7(d) exceed the net proceeds from
the offering received by such Holder. The relative fault of such indemnifying
party and indemnified party shall be determined by reference to, among other
things, whether any action in question, including any untrue or alleged untrue
statement of material fact or omission or alleged omission to state a material
fact, has been made by, or relates to information supplied by, such indemnifying
party or indemnified party, and the parties' relative intent, knowledge, access
to information and opportunity to correct or prevent such action. The amount
paid or payable by a party as a result of the losses, claims, damages or
liabilities referred to above shall be deemed to include any legal or other fees
or expenses reasonably incurred by such party in connection with any
investigation or proceeding.

            The parties hereto agree that it would not be just or equitable if
contribution pursuant to this Section 7(d) were determined by pro rata
allocation or by any other method of allocation which does not take account of
the equitable considerations referred to in the immediately preceding paragraph.
No person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the 1933 Act) shall be entitled to contribution from any person who was
not guilty of such fraudulent misrepresentation.

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      8. REPORTS UNDER THE SECURITIES EXCHANGE ACT OF 1934. With a view to
making available to the Holders the benefits of Rule 144 promulgated under the
1933 Act and any other rule or regulation of the SEC that may at any time permit
a Holder to sell securities of Flextronics to the public without registration or
pursuant to a registration on Form S-3, Flextronics agrees to:

            (a) make and keep public information available, as those terms are
understood and defined in SEC Rule 144, so long as Flextronics remains subject
to the periodic reporting requirements under Sections 13 or 15(d) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act");

            (b) file with the SEC in a timely manner all reports and other
documents required of Flextronics under the 1933 Act and the Exchange Act; and

            (c) furnish to any Holder, so long as the Holder owns any
Registrable Stock, forthwith upon written request (i) a written statement by
Flextronics that it has complied with the reporting requirements of SEC Rule
144, the 1933 Act and the Exchange Act, or that it qualifies as a registrant
whose securities may be resold pursuant to Form S-3, (ii) a copy of the most
recent annual or quarterly report of Flextronics and such other reports and
documents so filed by Flextronics, and (iii) such other information as may be
reasonably requested that is necessary or appropriate to avail any Holder of any
rule or regulation of the SEC which permits the selling of any such securities
without registration or pursuant to such form.

      9. LEGENDS. Each stock certificate representing Flextronics Ordinary
Shares issued pursuant to the Merger Agreement shall bear the following legend
(in addition to any legends required by applicable state laws):

      THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE "1933 ACT"). THESE
      SECURITIES MAY NOT BE OFFERED, SOLD, PLEDGED, OR TRANSFERRED UNLESS (1) A
      REGISTRATION STATEMENT UNDER THE 1933 ACT (AND A CURRENT PROSPECTUS) IS IN
      EFFECT AS TO THE SECURITIES, (2) AN EXEMPTION FROM THE REGISTRATION
      REQUIREMENTS OF THE 1933 ACT IS AVAILABLE, OR (3) THE SECURITIES ARE SOLD
      PURSUANT TO RULE 144 OF THE 1933 ACT. THE ISSUER OF THESE SECURITIES MAY
      REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE
      ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE
      WITH THE 1933 ACT AND ANY APPLICABLE STATE SECURITIES LAWS.

Flextronics may issue appropriate "stop transfer" instructions to its transfer
agent. Flextronics shall not be required (a) to transfer or have transferred on
its books any Flextronics Ordinary Shares issued pursuant to the Merger
Agreement that have been sold or otherwise transferred in violation of any of
the provisions of (i) the legend set forth in this Section 9, (ii) any other
provisions of the Merger Agreement or this Agreement, (iii) any applicable law
or (iv) the Selling Shareholder Questionnaire attached as Annex H to the Consent
Solicitation and Information Statement dated as of December 17, 2004, or (b) to
treat as owner of such shares or to accord the right to vote or pay dividends to
any purchaser or other transferee to whom such

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shares shall have been so transferred in violation of any law or of any
provision of the Merger Agreement, this Agreement or the Selling Shareholder
Questionnaire.

      10. GENERAL PROVISIONS.

            (a) Notices. Any notice, request or other communication required or
permitted hereunder shall be in writing and shall be deemed to have been duly
given if personally delivered, transmitted by facsimile (with confirmation of
successful electronic transmission), delivered by nationally recognized
overnight courier or if deposited in the U.S. mail by registered or certified
mail, return receipt requested, postage prepaid. Notices shall be delivered at
the addresses set forth in the signature page hereto. Any party hereto may by
notice so given change its address or facsimile number for future notices
hereunder. Notice shall conclusively be deemed to have been given when
personally delivered or on the third business day after deposit in the mail in
the manner set forth above.

            (b) Entire Agreement; Independence of Obligations. This Agreement
constitutes and contains the entire agreement and understanding of the parties
with respect to the subject matter hereof and supersedes any and all prior
negotiations, correspondence, agreements, understandings, duties or obligations
between the parties respecting the subject matter hereof. In the event of any
conflict between this Agreement and the Merger Agreement, the terms of this
Agreement shall control.

            (c) Governing Law. This Agreement shall be governed by and construed
in accordance with the internal laws of the State of California without regard
to conflicts of law principles.

            (d) Severability. If one or more provisions of this Agreement are
held to be unenforceable under applicable law, then such provision(s) shall be
excluded from this Agreement and the balance of this Agreement shall be
interpreted as if such provision(s) were so excluded and shall be enforceable in
accordance with its terms.

            (e) Third Parties. Nothing in this Agreement, express or implied, is
intended to confer upon any person, other than the parties hereto and their
successors, transferees (pursuant to Section 6) and assigns, any rights or
remedies under or by reason of this Agreement.

            (f) Successors and Assigns. Subject to the provisions of Section 6,
the provisions of this Agreement shall inure to the benefit of, and shall be
binding upon, the successors, transferees and permitted assigns of the parties
hereto.

            (g) Captions. The captions to sections of this Agreement have been
inserted for identification and reference purposes only and shall not be used to
construe or interpret this Agreement.

            (h) Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, and all of which
together shall constitute one instrument.

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            (i) Costs and Attorneys' Fees. In the event that any action, suit or
other proceeding is instituted concerning or arising out of this Agreement or
any transaction contemplated hereunder, the prevailing party shall recover all
of such party's costs and attorneys' fees incurred in each such action, suit or
other proceeding, including any and all appeals or petitions therefrom.

            (j) Adjustments for Stock Splits, Etc. Wherever in this Agreement
there is a reference to a specific number of Flextronics Ordinary Shares, then,
upon the occurrence of any subdivision, combination or share dividend of such
class of shares, the specific number of shares so referenced in this Agreement
shall automatically be proportionally adjusted to reflect the effect on the
outstanding shares of such class or series of shares by such subdivision,
combination or share dividend.

            (k) Arbitration of Disputes. Any disputes arising under this
Agreement shall be subject to the arbitration provisions set forth in Section
9.1 of the Merger Agreement.

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      IN WITNESS WHEREOF, the parties hereto have executed this Registration
Rights Agreement as of the date and year first above written.

FLEXTRONICS INTERNATIONAL LTD.

By: /s/ Manny Marimuthu

Name: Manny Marimuthu

Title: Authorized Signatory

HOLDER:
By: /s/ I.H. Yeh
Name: I.H. Yeh
Title: President
Address: Innovation LST. RD, Science-Based
Industrial Park, Hsin-Chu, Taiwan, R.O.C.
Facsimile: 886-3-5631369
Title: Elan Microelectronics Corporation

HOLDER:

By: /s/ HMC/ Oung, Sai Wah
Name: HMC/Oung, Sai Wah
Title: President
Address: 10-3 F, No. 351 Chung Shan Rd., Sec. 2 Chung Ho City,
Taipei, Taiwan R.O.C.
Facsimile: 886-2-8221-2976
Title: President

HOLDER:

By: /s/ Rong Yaw Wu
Name: Rong Yaw Wu
Title: President & CEO
Address: 5th Floor, No. 3, Alley 59, Lane 42
Min-Chiuan Rd., Hsin-Tien City, Taipei Hsein,
Taiwan
Facsimile: 886-2-2918-9823
Title: Pixon Technologies Corp.

HOLDER:

By: /s/ Ching-Lin Chen
Name: Ching-Lin Chen
Title:
Address:
Facsimile:
Title:

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HOLDER:

By: /s/ Chi-Jen Chien
Name: Chi-Jen Chien
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Paul T. Cody
Name: Paul T. Cody
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Ai-Lan Hsu
Name: Ai-Lan Hsu
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Oung, Sai Wah
Name: Oung, Sai Wah
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Ming-Jen Pang
Name: Ming-Jen Pang
Title:
Address:
Facsimile:
Title:

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HOLDER:

By: /s/ John P. Skurla
Name: John P. Skurla
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Rong Yaw Wu
Name: Rong Yaw Wu
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Wang Chung Kang
Name: Wang Chung Kang
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Yen-Chin Wang
Name: Yen-Chin Wang
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Lichune Margaret Wang
Name: Lichune Margaret Wang
Title:
Address:
Facsimile:
Title:

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HOLDER:

By: /s/ Chih-Chiu Pan
Name: Pan, Chih-Chiu
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Rusty Winzenread
Name: Rusty Winzenread
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Fu-Mei Loh
Name: Fu-Mei Loh
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Hsin-Fu Tseng
Name: Hsin-Fu- Tseng
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Napoleon Cereno
Name: Napoleon Cereno
Title:
Address:
Facsimile:
Title:

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HOLDER:

By: /s/ Tri Dang
Name: Tri Dang
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Phong Phan
Name: Phong Phan
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Shane (Sung-Ho) Rhee
Name: Shane (Sung-Ho) Rhee
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Phen B. Tan
Name: Phen B. Tan
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Satoru C. Tanaka
Name: Satoru C. Tanaka
Title:
Address:
Facsimile:
Title:

                                       14
<PAGE>

HOLDER:

By: /s/ Nga Dao
Name: Nga Dao
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Kuei-Mei Tseng
Name: Kuei-Mei Tseng
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Chinlee Wang
Name: Chinlee Wang
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Gene P. Weckler
Name: Gene P. Weckler
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Wai Shan Wong
Name: Wai Shan Wong
Title:
Address:
Facsimile:
Title:

                                       15
<PAGE>

HOLDER:

By: /s/ Pei Wang
Name: Pei Wang
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Heng W. Chen
Name: Heng W. Chen
Title:
Address:
Facsimile:
Title:

HOLDER:

By: /s/ Zhong Heng Mo
Name: Zhong Heng Mo
Title:
Address:
Facsimile:
Title:

                [SIGNATURE PAGE TO REGISTRATION RIGHTS AGREEMENT]

                                       16<PAGE>

                                                                   EXHIBIT 10.53

                           LOAN AND SECURITY AGREEMENT

      THIS LOAN AND SECURITY AGREEMENT (this "Agreement") dated as of December
28, 2004, between SILICON VALLEY BANK, a California chartered bank, with its
principal place of business at 3003 Tasman Drive, Santa Clara, California 95054
and with a loan production office located at One Newton Executive Park, Suite
200, 2221 Washington Street, Newton, Massachusetts 02462 ("Bank") and LYNX
THERAPEUTICS, INC., a Delaware corporation ("Borrower"), provides the terms on
which Bank shall lend to Borrower and Borrower shall repay Bank. The parties
agree as follows:

      1 ACCOUNTING AND OTHER TERMS

      Accounting terms not defined in this Agreement shall be construed
following GAAP. Calculations and determinations must be made following GAAP. The
term "financial statements" includes the notes and schedules. The terms
"including" and "includes" always mean "including (or includes) without
limitation," in this or any Loan Document. Capitalized terms in this Agreement
shall have the meanings set forth in Article 13. All other terms contained in
this Agreement, unless otherwise indicated, shall have the meaning provided by
the Code, to the extent such terms are defined therein.

      2 LOAN AND TERMS OF PAYMENT

      2.1 PROMISE TO PAY. Borrower hereby unconditionally promises to pay Bank
the unpaid principal amount of all Credit Extensions and interest on the unpaid
principal amount of the Credit Extensions as and when due in accordance with
this Agreement.

      2.1.1 BRIDGE LOAN.

            (a) Bank shall make an advance ("Bridge Loan Advance") not exceeding
the Bridge Loan, within two (2) days of the Closing Date. The outstanding
principal amount of the Bridge Loan Advance, plus all accrued interest shall be
due and payable on the Bridge Loan Maturity Date. The Bridge Loan Advance, after
repayment, may not be reborrowed.

            (b) To obtain the Bridge Loan Advance, Borrower must notify Bank
(which notice shall be irrevocable) by facsimile or telephone by 12:00 noon
Pacific time on the Business Day the Bridge Loan Advance is to be made. If such
notification is by telephone, Borrower must promptly confirm the notification by
delivering to Bank a completed Payment/Advance Form in the form attached as
EXHIBIT B. Bank shall credit the Bridge Loan Advance to Borrower's deposit
account. Bank may make the Bridge Loan Advance under this Agreement based on
instructions from a Responsible Officer or his or her designee or without
instructions if the Bridge Loan Advance is necessary to meet Obligations which
have become due. Bank may rely on any telephone notice given by a person whom
Bank believes is a Responsible Officer or designee. Borrower shall indemnify
Bank for any loss Bank suffers due to such reliance.

            (c) Borrower may voluntarily prepay without penalty or premium all
or a portion of the Bridge Loan Advance at any time by tendering to Bank cash
payment in respect of such Bridge Loan Advance in an amount equal to the sum of
all principal and all accrued and unpaid interest on such Bridge Loan Advance as
of the date of prepayment plus all Bank Expenses.

      2.1.2 UNDISBURSED CREDIT EXTENSIONS. The Bank's obligation to lend the
undisbursed portion of the Obligations shall terminate if, in Bank's sole
discretion, there has been a material adverse change in the general affairs,
management, results of operation, condition (financial or otherwise) or the
prospect of repayment of the Obligations, or there has been any material adverse
deviation by Borrower from the most recent business plan of Borrower presented
to and accepted by Bank prior to the execution of this Agreement.

      2.2 INTEREST RATE

            (a) Interest Rate. The principal amounts outstanding under the
Bridge Loan shall accrue interest at a fixed per annum rate equal to ten percent
(10.0%), which interest shall be payable monthly.

<PAGE>

            (b) Default Rate. After an Event of Default, Obligations shall bear
interest at five percent (5.0%) above the rate effective immediately before the
Event of Default.

            (c) 360-Day Year. Interest is computed on the basis of a 360 day
year for the actual number of days elapsed.

            (d) Debit of Accounts. Bank may debit any of Borrower's deposit or
operating accounts, including Account Number __________, for principal and
interest payments when due, or any other amounts Borrower owes Bank, when due.
Bank shall promptly notify Borrower after it debits Borrower's accounts. These
debits shall not constitute a set-off.

            (e) Payments. Interest is payable in arrears monthly on the first
calendar day of each month. Payments received after 12:00 noon Pacific time are
considered received at the opening of business on the next Business Day. When a
payment is due on a day that is not a Business Day, the payment is due the next
Business Day and additional fees or interest, as applicable, shall continue to
accrue.

      2.3 FEES. Borrower shall pay to Bank:

            (a) Commitment Fee. A fully earned, non-refundable commitment fee of
Thirty Thousand Dollars ($30,000.00) due and payable on the Closing Date;

            (b) Good Faith Deposit. Borrower has paid to Bank a Good Faith
Deposit of Ten Thousand Dollars ($10,000.00) (the "Good Faith Deposit") to
initiate Bank's due diligence review process. On the Closing Date, the Good
Faith Deposit shall be applied to the Bank Expenses through the Closing Date,
and the balance, if any, shall be applied to the Commitment Fee; and

            (c) Bank Expenses. All Bank Expenses (including reasonable
attorneys' fees and expenses) incurred through and after the Closing Date, when
due.

      2.4 ADDITIONAL COSTS. If any law or regulation adopted after the date
hereof increases Bank's costs or reduces its income for any loan, Borrower shall
pay the increase in cost or reduction in income or additional expense; provided,
however, that Borrower shall not be liable for any amount attributable to any
period before 180 days prior to the date Bank notifies Borrower of such
increased costs. Bank agrees that it shall allocate any increased costs among
its customers similarly affected in good faith and in a manner consistent with
Bank's customary practice.

      3 CONDITIONS OF LOANS

      3.1 CONDITIONS PRECEDENT TO INITIAL CREDIT EXTENSION. The Bank's
obligation to make the initial Credit Extension is subject to the condition
precedent that Bank shall have received, in form and substance satisfactory to
Bank, such documents, and completion of such other matters, as Bank may
reasonably deem necessary or appropriate, including, without limitation, subject
to the condition precedent that Bank shall have received, in form and substance
satisfactory to Bank, the following:

            (a) this Agreement;

            (b) a certificate of the Acting Chief Financial Officer of Borrower
with respect to the certificate of incorporation, bylaws, incumbency and
resolutions authorizing the execution and delivery of this Agreement;

            (c) a legal opinion of Borrower's counsel (authority and
enforceability), in form and substance acceptable to Bank;

            (d) an Intellectual Property Security Agreement;

                                      -2-
<PAGE>

            (e) Subordination Agreement between Solexa Limited, a company
registered in England and Wales ("Solexa") and Bank;

            (f) satisfies all consents and waivers as set forth in Section 14(b)
of the Perfection Certificate;

            (g) Perfection Certificate by Borrower ;

            (h) Warrant to Purchase Stock;

            (i) Account Control Agreement/Investment Account Control Agreement;

            (j) insurance certificate;

            (k) payment of the fees and Bank Expenses then due specified in
Section 2.3 hereof;

            (l) Certificate of Foreign Qualification issued by the Secretary of
State of the State of California;

            (m) Certificate of Good Standing issued by the Secretary of State of
the State of Delaware; and

            (n) such other documents, and completion of such other matters, as
Bank may reasonably deem necessary or appropriate.

      3.2 CONDITIONS PRECEDENT TO ALL CREDIT EXTENSIONS. Bank's obligations to
make each Credit Extension, including the initial Credit Extension, is subject
to the following:

            (a) timely receipt of any Payment/Advance Form; and

            (b) the representations and warranties in Section 5 shall be true in
all material respects on the date of the Payment/Advance Form and on the
effective date of each Credit Extension and no Event of Default shall have
occurred and be continuing, or result from the Credit Extension. Each Credit
Extension is Borrower's representation and warranty on that date that the
representations and warranties in Section 5 remain true in all material
respects.

      4 CREATION OF SECURITY INTEREST

      4.1 GRANT OF SECURITY INTEREST. Borrower hereby grants Bank, to secure the
payment and performance in full of all of the Obligations and the performance of
each of Borrower's duties under the Loan Documents, a continuing security
interest in, and pledges and assigns to the Bank, the Collateral, wherever
located, whether now owned or hereafter acquired or arising, and all proceeds
and products thereof. Borrower warrants and represents that the security
interest granted herein shall be a first priority security interest in the
Collateral.

Except as noted on the Perfection Certificate, Borrower is not a party to, nor
is bound by, any material license (other than over the counter software that is
commercially available to the public) or other material agreement with respect
to which the Borrower is the licensee that prohibits or otherwise restricts
Borrower from granting a security interest in Borrower's interest in such
license or agreement or any other property. Borrower shall provide written
notice to Bank within ten (10) days of entering or becoming bound by, any such
license or agreement which is reasonably likely to have a material impact on
Borrower's business or financial condition. Borrower shall take such steps as
Bank reasonably requests to obtain the consent of, authorization by or waiver
by, any person whose consent or waiver is necessary for all such licenses or
contract rights to be deemed "Collateral" and for Bank to have a security
interest in it that might otherwise be restricted or prohibited by law or by the
terms of any such license or agreement, whether now existing or entered into in
the future.

                                      -3-
<PAGE>

If the Agreement is terminated, Bank's lien and security interest in the
Collateral shall continue until Borrower fully satisfies its Obligations. If
Borrower shall at any time, acquire a commercial tort claim, Borrower shall
promptly notify Bank in a writing signed by Borrower of the brief details
thereof and grant to Bank in such writing a security interest therein and in the
proceeds thereof, all upon the terms of this Agreement, with such writing to be
in form and substance satisfactory to Bank.

      4.2 AUTHORIZATION TO FILE FINANCING STATEMENTS. Borrower hereby authorizes
Bank to file financing statements, without notice to Borrower, with all
appropriate jurisdictions in order to perfect or protect Bank's interest or
rights hereunder, including a notice that any disposition of the Collateral, by
either the Borrower or any other Person, shall be deemed to violate the rights
of the Bank under the Code.

      5 REPRESENTATIONS AND WARRANTIES

      Borrower represents and warrants as follows:

      5.1 DUE ORGANIZATION AND AUTHORIZATION. Borrower and each Subsidiary is
duly existing and in good standing in its state of formation and qualified and
licensed to do business in, and in good standing in, any state in which the
conduct of its business or its ownership of property requires that it be
qualified except where the failure to do so could not reasonably be expected to
cause a Material Adverse Change. In connection with this Agreement, the Borrower
delivered to the Bank a certificate signed by the Borrower and entitled
"Perfection Certificate". The Borrower represents and warrants to the Bank that:
(a) the Borrower's exact legal name is that indicated on the Perfection
Certificate and on the signature page hereof; and (b) the Borrower is an
organization of the type, and is organized in the jurisdiction, set forth in the
Perfection Certificate; and (c) the Perfection Certificate accurately sets forth
the Borrower's organizational identification number or accurately states that
the Borrower has none; and (d) the Perfection Certificate accurately sets forth
the Borrower's place of business, or, if more than one, its chief executive
office as well as the Borrower's mailing address if different, and (e) all other
information set forth on the Perfection Certificate pertaining to the Borrower
is accurate and complete. If the Borrower does not now have an organizational
identification number, but later obtains one, Borrower shall forthwith notify
the Bank of such organizational identification number.

      Except as set forth in the Perfection Certificate, the execution, delivery
and performance of the Loan Documents have been duly authorized, and do not
conflict with Borrower's organizational documents, nor constitute an event of
default under any material agreement by which Borrower is bound. Borrower is not
in default under any agreement to which or by which it is bound in which the
default could reasonably be expected to cause a Material Adverse Change.

      5.2 COLLATERAL. Borrower has good title to the Collateral, free of Liens
except Permitted Liens. Borrower has no deposit account, other than the deposit
accounts with Bank and deposit accounts described in the Perfection Certificate
delivered to the Bank in connection herewith. The Accounts are bona fide,
existing obligations, and the service or property has been performed or
delivered to the account debtor or its agent for immediate shipment to and
unconditional acceptance by the account debtor. The Collateral is not in the
possession of any third party bailee (such as a warehouse). Except as hereafter
disclosed to the Bank in writing by Borrower, none of the components of the
Collateral shall be maintained at locations other than as provided in the
Perfection Certificate. In the event that Borrower, after the date hereof,
intends to store or otherwise deliver any portion of the Collateral to a bailee,
then Borrower will first receive the written consent of Bank and such bailee
must acknowledge in writing that the bailee is holding such Collateral for the
benefit of Bank. All Inventory is in all material respects of good and
marketable quality, free from material defects. Borrower is the sole owner of
the Intellectual Property, except for non-exclusive licenses granted to its
customers in the ordinary course of business and as set forth in the Perfection
Certificate. Each Patent is valid and enforceable and no part of the
Intellectual Property has been judged invalid or unenforceable, in whole or in
part, and no claim has been made that any part of the Intellectual Property
violates the rights of any third party except to the extent such claim could not
reasonably be expected to cause a Material Adverse Change.

      5.3 LITIGATION. Except as shown in the Perfection Certificate, there are
no actions or proceedings pending or, to the knowledge of Borrower's Responsible
Officers, threatened by or against Borrower or any Subsidiary in which an
adverse decision could reasonably be expected to cause a Material Adverse
Change.

                                      -4-
<PAGE>

      5.4 NO MATERIAL DEVIATION IN FINANCIAL STATEMENTS. All consolidated
financial statements for Borrower and any Subsidiary delivered to Bank fairly
present in all material respects Borrower's consolidated financial condition and
Borrower's consolidated results of operations. There has not been any material
deterioration in Borrower's consolidated financial condition since the date of
the most recent financial statements submitted to Bank.

      5.5 SOLVENCY. The fair salable value of Borrower's assets (including
goodwill minus disposition costs) exceeds the fair value of its liabilities; the
Borrower is not left with unreasonably small capital after the transactions in
this Agreement; and Borrower is able to pay its debts (including trade debts) as
they mature.

      5.6 REGULATORY COMPLIANCE. Borrower is not an "investment company" or a
company "controlled" by an "investment company" under the Investment Company
Act. Borrower is not engaged as one of its important activities in extending
credit for margin stock (under Regulations T and U of the Federal Reserve Board
of Governors). Borrower has complied in all material respects with the Federal
Fair Labor Standards Act. Borrower has not violated any laws, ordinances or
rules, the violation of which could reasonably be expected to cause a Material
Adverse Change. None of Borrower's or any Subsidiary's properties or assets has
been used by Borrower or any Subsidiary or, to the best of Borrower's knowledge,
by previous Persons, in disposing, producing, storing, treating, or transporting
any hazardous substance other than legally. Borrower and each Subsidiary has
timely filed all required tax returns and paid, or made adequate provision to
pay, all material taxes, except those being contested in good faith with
adequate reserves under GAAP. Borrower and each Subsidiary has obtained all
consents, approvals and authorizations of, made all declarations or filings
with, and given all notices to, all government authorities that are necessary to
continue its business as currently conducted except where the failure to make
such declarations, notices or filings would not reasonably be expected to cause
a Material Adverse Change.

      5.7 SUBSIDIARIES. Borrower does not own any stock, partnership interest or
other equity securities except for Permitted Investments.

      5.8 FULL DISCLOSURE. No written representation, warranty or other
statement of Borrower in any certificate or written statement given to Bank
taken together with all such written certificates and written statements given
to Bank contains any untrue statement of a material fact or omits to state a
material fact necessary to make the statements contained in the certificates or
statements not misleading (it being recognized by Bank that the projections and
forecasts provided by Borrower in good faith and based upon reasonable
assumptions are not viewed as facts and that actual results during the period or
periods covered by such projections and forecasts may differ from the projected
or forecasted results).

      6 AFFIRMATIVE COVENANTS

      Borrower shall do all of the following:

      6.1 GOVERNMENT COMPLIANCE. Borrower shall maintain its and all
Subsidiaries' legal existence and good standing in its jurisdiction of formation
and maintain qualification in each jurisdiction in which the failure to so
qualify would reasonably be expected to have a material adverse effect on
Borrower's business or operations. Borrower shall comply, and have each
Subsidiary comply, with all laws, ordinances and regulations to which it is
subject, noncompliance with which could have a material adverse effect on
Borrower's business or operations or would reasonably be expected to cause a
Material Adverse Change.

      6.2 FINANCIAL STATEMENTS, REPORTS, CERTIFICATES.

            (a) Borrower shall deliver to Bank: (i) as soon as available, but no
later than thirty (30) days after the last day of each month, a company prepared
consolidated balance sheet and income statement covering Borrower's consolidated
operations during the period certified by a Responsible Officer and in a form
reasonably acceptable to Bank; (ii) within five (5) days of filing, Borrower
will provide to Bank copies of or electronic notice of links to all statements,
reports and notices made available to Borrower' s security holders or to any
holders of Subordinated Debt and all reports on Form 10-K, 10-Q and 8-K filed
with the Securities and Exchange Commission; (iii) a prompt report of any legal
actions pending or threatened against Borrower or any Subsidiary that could
result in damages or costs to Borrower or any Subsidiary of One Hundred Thousand
Dollars ($100,000.00) or more; (iv) prompt notice of any material change in the
composition of the Intellectual Property, or the registration of any

                                      -5-
<PAGE>

copyright, including any subsequent ownership right of Borrower in or to any
Copyright, Patent or Trademark not shown in any intellectual property security
agreement between Borrower and Bank or knowledge of an event that materially
adversely affects the value of the Intellectual Property; and (v) budgets, sales
projections, operating plans or other financial information reasonably requested
by Bank.

            (b) Within THIRTY (30) days after the last day of each month,
Borrower shall deliver to Bank with the monthly financial statements a
Compliance Certificate signed by a Responsible Officer in the form of EXHIBIT C.

      6.3 INVENTORY; RETURNS. Borrower shall keep all Inventory in good and
marketable condition, free from material defects. Returns and allowances between
Borrower and its account debtors shall follow Borrower's customary practices as
they exist at the Closing Date. Borrower must promptly notify Bank of all
returns, recoveries, disputes and claims that involve more than Fifty Thousand
Dollars ($50,000.00).

      6.4 TAXES. Borrower shall make, and cause each Subsidiary to make, timely
payment of all material federal, state, and local taxes or assessments (other
than taxes and assessments which Borrower is contesting in good faith, with
adequate reserves maintained in accordance with GAAP) and will deliver to Bank,
on demand, appropriate certificates attesting to such payments.

      6.5 INSURANCE. Borrower shall keep its business and the Collateral insured
for risks and in amounts, and as Bank may reasonably request. Insurance policies
shall be in a form, with companies, and in amounts that are satisfactory to
Bank. All property policies shall have a lender's loss payable endorsement
showing Bank as an additional loss payee and all liability policies shall show
the Bank as an additional insured and all policies shall provide that the
insurer must give Bank at least twenty (20) days notice before canceling its
policy. At Bank's request, Borrower shall deliver certified copies of policies
and evidence of all premium payments. Proceeds payable under any policy shall,
at Bank's option, be payable to Bank on account of the Obligations.
Notwithstanding the foregoing, so long as no Event of Default has occurred and
is continuing, Borrower shall have the option of applying the proceeds of any
casualty policy up to $200,000.00, in the aggregate, toward the replacement or
repair of destroyed or damaged property; provided that (i) any such replaced or
repaired property (a) shall be of equal or like value as the replaced or
repaired Collateral and (b) shall be deemed Collateral in which Bank has been
granted a first priority security interest and (ii) after the occurrence and
during the continuation of an Event of Default all proceeds payable under such
casualty policy shall, at the option of the Bank, be payable to Bank on account
of the Obligations. If Borrower fails to obtain insurance as required under
Section 6.5 or to pay any amount or furnish any required proof of payment to
third persons and the Bank, Bank may make all or part of such payment or obtain
such insurance policies required in Section 6.5, and take any action under the
policies Bank deems prudent.

      6.6 ACCOUNTS.

            (a) In order to permit the Bank to monitor the Borrower's financial
performance and condition, Borrower shall maintain Borrower's depository (with
the exception of deposit accounts exclusively used for current payroll, and
current payroll taxes), operating and securities accounts with Bank, and all of
the Borrower's cash or securities in excess of that amount used for Borrower's
operations shall be maintained at the Bank, except for Borrower's investment
accounts set forth on the Perfection Certificate (which Borrower will close at
other institutions within fifteen (15) days of this Agreement).

            (b) Borrower shall identify to Bank, in writing, any bank or
securities account opened by Borrower with any institution other than Bank. In
addition, for each such account that the Borrower or Guarantor at any time opens
or maintains, Borrower shall, at the Bank's request and option, pursuant to an
agreement in form and substance acceptable to the Bank, cause the depository
bank or securities intermediary to agree that such account is the collateral of
the Bank pursuant to the terms hereunder. The provisions of the previous
sentence shall not apply to deposit accounts exclusively used for payroll,
payroll taxes and other employee wage and benefit payments to or for the benefit
of the Borrower's employees.

      6.7 REGISTRATION OF INTELLECTUAL PROPERTY RIGHTS. Borrower shall not
register any Copyrights or Mask Works in the United States Copyright Office
unless it: (i) has given at least fifteen (15) days' prior written notice to
Bank of its intent to register such Copyrights or Mask Works and has provided
Bank with a copy of the application it intends to file with the United States
Copyright Office (excluding exhibits thereto); (ii) executes a

                                      -6-
<PAGE>

security agreement/IP Agreement or such other documents as Bank may reasonably
request in order to maintain the perfection and priority of Bank's security
interest in the Copyrights proposed to be registered with the United States
Copyright Office; and (iii) records such security agreement/ IP Agreement with
the United States Copyright Office contemporaneously with filing the Copyright
application(s) with the United States Copyright Office. Borrower shall promptly
provide to Bank a copy of the Copyright application(s) filed with the United
States Copyright Office, together with evidence of the recording of the security
documents necessary for Bank to maintain the perfection and priority of its
security interest in such Copyrights or Mask Works. Borrower shall provide
written notice to Bank of any application filed by Borrower in the United States
Patent Trademark Office for a patent or to register a trademark or service mark
within 30 days of any such filing.

      Borrower shall: (i) protect, defend and maintain the validity and
enforceability of the Intellectual Property; (ii) promptly advise Bank in
writing of material infringements of the Intellectual Property; and (iii) not
allow any Intellectual Property material to the Borrower's business to be
abandoned, forfeited or dedicated to the public without Bank's written consent.

      6.8 FURTHER ASSURANCES. Borrower shall execute any further instruments and
take further action as Bank reasonably requests to perfect or continue Bank's
security interest in the Collateral or to effect the purposes of this Agreement.

      7 NEGATIVE COVENANTS

      Borrower shall not do any of the following without the Bank's prior
written consent.

      7.1 DISPOSITIONS. Convey, sell, lease, transfer, assign or otherwise
dispose of (collectively a "Transfer"), or permit any of its Subsidiaries to
Transfer, all or any part of its business or property, including the
Intellectual Property, except for Transfers (i) of Inventory in the ordinary
course of business; (ii) of non-exclusive licenses and similar arrangements for
the use of the property of Borrower or its Subsidiaries in the ordinary course
of business; or (iii) of worn-out or obsolete Equipment. The Borrower shall not
enter into an agreement with any Person other than the Bank which restricts the
subsequent granting of a security interest in the Intellectual Property.

      7.2 CHANGES IN BUSINESS, OWNERSHIP, MANAGEMENT OR BUSINESS LOCATIONS.
Without the Bank's prior written consent, which shall not be unreasonably
withheld, engage in or permit any of its Subsidiaries to engage in any business
other than the businesses currently engaged in by Borrower or reasonably related
thereto, or have a material change in its ownership (other than by the sale of
Borrower's equity securities in a public offering or to venture capital
investors so long as Borrower identifies to Bank the venture capital investors
prior to the closing of the investment), or management. Borrower shall not,
without prior written notice to Bank: (i) relocate its chief executive office,
or add any new offices or business locations, including warehouses (unless such
new offices or business locations contain less than Five Thousand Dollars
($5,000.00) in Borrower's assets or property), or (ii) change its jurisdiction
of organization, or (iii) change its organizational structure or type, or (iv)
change its legal name, or (v) change any organizational number (if any) assigned
by its jurisdiction of organization.

      7.3 MERGERS OR ACQUISITIONS. Without the Bank's prior written consent,
which shall not be unreasonably withheld, merge or consolidate, or permit any of
its Subsidiaries to merge or consolidate, with any other Person, or acquire, or
permit any of its Subsidiaries to acquire, all or substantially all of the
capital stock or property of another Person. A Subsidiary may merge or
consolidate into another Subsidiary or into Borrower.

      7.4 INDEBTEDNESS. Create, incur, assume, or be liable for any
Indebtedness, or permit any Subsidiary to do so, other than Permitted
Indebtedness.

      7.5 ENCUMBRANCE. Create, incur, or allow any Lien on any of its property,
including the Intellectual Property, or assign or convey any right to receive
income, including the sale of any Accounts, or permit any of its Subsidiaries to
do so, except for Permitted Liens, or permit any Collateral not to be subject to
the first priority security interest granted herein. The Collateral may also be
subject to Permitted Liens.

      7.6 DISTRIBUTIONS; INVESTMENTS. Without the Bank's prior written consent,
which shall not be unreasonably withheld: (i) Directly or indirectly acquire or
own any Person, or make any Investment in any Person, other than Permitted
Investments, or permit any of its Subsidiaries to do so; or (ii) pay any
dividends or make any

                                      -7-
<PAGE>

distribution or payment or redeem, retire or purchase any capital stock, except
for (A) dividends and distributions solely in the capital stock of Borrower and
(B) repurchases of stock from former employees or directors of Borrower under
the terms of applicable repurchase agreements in an aggregate amount not to
exceed One Hundred Thousand Dollars ($100,000.00) in the aggregate in any fiscal
year, provided that no Event of Default has occurred, is continuing or would
exist after giving effect to the repurchases.

      7.7 TRANSACTIONS WITH AFFILIATES. Directly or indirectly enter into or
permit to exist any material transaction with any Affiliate of Borrower, except
for transactions that are in the ordinary course of Borrower's business, upon
fair and reasonable terms that are no less favorable to Borrower than would be
obtained in an arm's length transaction with a non-affiliated Person; provided,
however, Borrower may enter into a private placement or other filing
transaction(s) involving the shareholders of Solexa without the Bank's prior
written consent.

      7.8 SUBORDINATED DEBT. Make or permit any payment on any Subordinated
Debt, except under the terms of the Subordinated Debt, or amend any provision in
any document relating to the Subordinated Debt, without Bank's prior written
consent.

      7.9 COMPLIANCE. Become an "investment company" or a company controlled by
an "investment company", under the Investment Company Act of 1940 or undertake
as one of its important activities extending credit to purchase or carry margin
stock, or use the proceeds of any Credit Extension for that purpose; fail to
meet the minimum funding requirements of ERISA, permit a Reportable Event or
Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the
Federal Fair Labor Standards Act or violate any other law or regulation, if the
violation could reasonably be expected to have a material adverse effect on
Borrower's business or operations or would reasonably be expected to cause a
Material Adverse Change, or permit any of its Subsidiaries to do so.

      8 EVENTS OF DEFAULT

      Any one of the following is an Event of Default:

      8.1 PAYMENT DEFAULT. Borrower fails to pay any of the Obligations within
three (3) days after their due date. During such three (3) day period the
failure to cure the default shall not constitute an Event of Default (but no
Credit Extension shall be made during such period);

      8.2 COVENANT DEFAULT. (i) Borrower fails or neglects to perform any
obligation in Section 6.2, 6.6 and 6.7 or violates any covenant in Section 7; or
(ii) Borrower fails or neglects to perform, keep, or observe any other material
term, provision, condition, covenant or agreement contained in this Agreement,
any Loan Documents, or in any present or future agreement between Borrower and
Bank and as to any default under such other material term, provision, condition,
covenant or agreement that can be cured, has failed to cure the default within
ten (10) days after the occurrence thereof; provided, however, that if the
default cannot by its nature be cured within the ten (10) day period or cannot
after diligent attempts by Borrower be cured within such ten (10) day period,
and such default is likely to be cured within a reasonable time, then Borrower
shall have an additional period (which shall not in any case exceed thirty (30)
days) to attempt to cure such default, and within such reasonable time period
the failure to cure the default shall not be deemed an Event of Default (but no
Credit Extensions shall be made during such cure period). Grace periods provided
under this section shall not apply, among other things, to financial covenants
or any other covenants that are required to be satisfied, completed or tested by
a date certain;

      8.3 MATERIAL ADVERSE CHANGE. A Material Adverse Change occurs;

      8.4 ATTACHMENT. (i) Any material portion of Borrower's assets is attached,
seized, levied on, or comes into possession of a trustee or receiver and the
attachment, seizure or levy is not removed in ten (10) days; (ii) the service of
process upon the Borrower seeking to attach, by trustee or similar process, any
funds of the Borrower on deposit with the Bank, or any entity under control of
Bank (including a subsidiary); (iii) Borrower is enjoined, restrained, or
prevented by court order from conducting a material part of its business; (iv) a
judgment or other claim becomes a Lien on a material portion of Borrower's
assets; or (v) a notice of lien, levy, or assessment is filed against any of
Borrower's assets by any government agency and not paid within ten (10) days
after Borrower receives notice. These are not Events of Default if stayed or if
a bond is posted pending contest by Borrower (but no Credit Extensions shall be
made during the cure period);

                                      -8-
<PAGE>

      8.5 INSOLVENCY. (i) Borrower is unable to pay its debts (including trade
debts) as they become due or otherwise becomes insolvent; (ii) Borrower begins
an Insolvency Proceeding; or (iii) an Insolvency Proceeding is begun against
Borrower and not dismissed or stayed within thirty (30) days (but no Credit
Extensions shall be made before any Insolvency Proceeding is dismissed);

      8.6 OTHER AGREEMENTS. If there is a default in any agreement to which
Borrower is a party with a third party or parties resulting in a right by such
third party or parties, whether or not exercised, to accelerate the maturity of
any Indebtedness in an amount in excess of One Hundred Thousand Dollars
($100,000.00) or that could result in a Material Adverse Change;

      8.7 JUDGMENTS. If a judgment or judgments for the payment of money in an
amount, individually or in the aggregate, of at least One Hundred Thousand
Dollars ($100,000.00) shall be rendered against Borrower and shall remain
unsatisfied and unstayed for a period of ten (10) days (provided that no Credit
Extensions will be made prior to the satisfaction or stay of such judgment);

      8.8 MISREPRESENTATIONS. If Borrower or any Person acting for Borrower
makes any material misrepresentation or material misstatement now or later in
any warranty or representation in this Agreement or in any writing delivered to
Bank or to induce Bank to enter this Agreement or any Loan Document;

      8.9 SUBORDINATED DEBT. A default or breach occurs under any agreement
between Borrower and any creditor of Borrower that signed a subordination
agreement with Bank, or any creditor that has signed a subordination agreement
with Bank breaches any terms of the subordination agreement;

      9 BANK'S RIGHTS AND REMEDIES

      9.1 RIGHTS AND REMEDIES. When an Event of Default occurs and continues
Bank may, without notice or demand, do any or all of the following:

            (a) Declare all Obligations immediately due and payable (but if an
Event of Default described in Section 8.5 occurs all Obligations are immediately
due and payable without any action by Bank);

            (b) Stop advancing money or extending credit for Borrower's benefit
under this Agreement or under any other agreement between Borrower and Bank;

            (c) Settle or adjust disputes and claims directly with account
debtors for amounts, on terms and in any order that Bank considers advisable and
notify any Person owing Borrower money of Bank's security interest in such funds
and verify the amount of such account;

            (d) Make any payments and do any acts it considers necessary or
reasonable to protect its security interest in the Collateral. Borrower shall
assemble the Collateral if Bank requests and make it available as Bank
designates. Bank may enter premises where the Collateral is located, take and
maintain possession of any part of the Collateral, and pay, purchase, contest,
or compromise any Lien which appears to be prior or superior to its security
interest and pay all expenses incurred. Borrower grants Bank a license to enter
and occupy any of its premises, without charge, to exercise any of Bank's rights
or remedies;

            (e) Apply to the Obligations any (i) balances and deposits of
Borrower it holds, or (ii) any amount held by Bank owing to or for the credit or
the account of Borrower;

            (f) Ship, reclaim, recover, store, finish, maintain, repair, prepare
for sale, advertise for sale, and sell the Collateral. Bank is hereby granted a
non-exclusive, royalty-free license or other right to use, without charge,
Borrower's labels, patents, copyrights, mask works, rights of use of any name,
trade secrets, trade names, trademarks, service marks, and advertising matter,
or any similar property as it pertains to the Collateral, in completing
production of, advertising for sale, and selling any Collateral and, in
connection with Bank's exercise of its rights under this Section, Borrower's
rights under all licenses and all franchise agreements inure to Bank's benefit;

                                      -9-
<PAGE>

            (g) Place a "hold" on any account maintained with Bank and/or
deliver a notice of exclusive control, any entitlement order, or other
directions or instructions pursuant to any control agreement or similar
agreements providing control of any Collateral. Bank agrees that it shall not
deliver any such notice of exclusive control except upon the occurrence and
continuation of an Event of Default; and

            (h) Exercise all rights and remedies and dispose of the Collateral
according to the Code.

      9.2 POWER OF ATTORNEY. Borrower hereby irrevocably appoints Bank as its
lawful attorney-in-fact, to be effective upon the occurrence and during the
continuance of an Event of Default, to: (i) endorse Borrower's name on any
checks or other forms of payment or security; (ii) sign Borrower's name on any
invoice or bill of lading for any Account or drafts against account debtors;
(iii) settle and adjust disputes and claims about the Accounts directly with
account debtors, for amounts and on terms Bank determines reasonable; (iv) make,
settle, and adjust all claims under Borrower's insurance policies; and (v)
transfer the Collateral into the name of Bank or a third party as the Code
permits. Borrower hereby appoints Bank as its lawful attorney-in-fact to sign
Borrower's name on any documents necessary to perfect or continue the perfection
of any security interest regardless of whether an Event of Default has occurred
until all Obligations have been satisfied in full and Bank is under no further
obligation to make Credit Extensions hereunder. Bank's foregoing appointment as
Borrower's attorney in fact, and all of Bank's rights and powers, coupled with
an interest, are irrevocable until all Obligations have been fully repaid and
performed and Bank's obligation to provide Credit Extensions terminates.

      9.3 ACCOUNTS NOTIFICATION/COLLECTION. In the event that an Event of
Default occurs and is continuing, Bank may notify any Person owing Borrower
money of Bank's security interest in the funds and verify and/or collect the
amount of the Account. After the occurrence of an Event of Default, any amounts
received by Borrower shall be held in trust by Borrower for Bank, and, if
requested by Bank, Borrower shall immediately deliver such receipts to Bank in
the form received from the account debtor, with proper endorsements for deposit.

      9.4 BANK EXPENSES. Any amounts paid by Bank as provided herein shall
constitute Bank Expenses and are immediately due and payable, and shall bear
interest at the then applicable rate and be secured by the Collateral. No
payments by Bank shall be deemed an agreement to make similar payments in the
future or Bank's waiver of any Event of Default.

      9.5 BANK'S LIABILITY FOR COLLATERAL. So long as the Bank complies with
reasonable banking practices regarding the safekeeping of collateral, the Bank
shall not be liable or responsible for: (a) the safekeeping of the Collateral;
(b) any loss or damage to the Collateral; (c) any diminution in the value of the
Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or
other Person. Borrower bears all risk of loss, damage or destruction of the
Collateral.

      9.6 REMEDIES CUMULATIVE. Bank's rights and remedies under this Agreement,
the Loan Documents, and all other agreements are cumulative. Bank has all rights
and remedies provided under the Code, by law, or in equity. Bank's exercise of
one right or remedy is not an election, and Bank's waiver of any Event of
Default is not a continuing waiver. Bank's delay is not a waiver, election, or
acquiescence. No waiver hereunder shall be effective unless signed by Bank and
then is only effective for the specific instance and purpose for which it was
given.

      9.7 DEMAND WAIVER. Borrower waives demand, notice of default or dishonor,
notice of payment and nonpayment, notice of any default, nonpayment at maturity,
release, compromise, settlement, extension, or renewal of accounts, documents,
instruments, chattel paper, and guarantees held by Bank on which Borrower is
liable.

      10 NOTICES

      All notices or demands by any party to this Agreement or any other related
agreement must be in writing and be personally delivered or sent by an overnight
delivery service, by certified mail, postage prepaid, return receipt requested,
or by telefacsimile at the addresses listed below. Either Bank or Borrower may
change its notice address by giving the other party written notice.

                                      -10-
<PAGE>

                If to Borrower:    Lynx Therapeutics, Inc.
                                   25861 Industrial Boulevard
                                   Hayward, California 94545
                                   Attn: Chief Executive Officer
                                   FAX: (510) 670-9302

                with a copy to:    Cooley Godward LLP
                                   Five Palo Alto Square
                                   3000 El Camino Real
                                   Palo Alto, California 94306
                                   Attn: James C. Kitch, Esquire
                                   FAX:(650) 849-7400

                If to Bank:        Silicon Valley Bank
                                   One Newton Executive Park, Suite 200
                                   2221 Washington Street
                                   Newton, Massachusetts  02462
                                   Attn: Mr. Michael Hanewich
                                   Fax: (617) 969-4395

                with a copy to:    Riemer & Braunstein LLP
                                   Three Center Plaza
                                   Boston, Massachusetts 02108
                                   Attn: David A. Ephraim, Esquire
                                   FAX: (617) 880-3456

      11 CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER

      California law governs the Loan Documents without regard to principles of
conflicts of law. Borrower and Bank each submit to the exclusive jurisdiction of
the State and Federal courts in California and Borrower accepts jurisdiction of
the courts and venue in Santa Clara County, California. NOTWITHSTANDING THE
FOREGOING, THE BANK SHALL HAVE THE RIGHT TO BRING ANY ACTION OR PROCEEDING
AGAINST THE BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER JURISDICTION
WHICH THE BANK DEEMS NECESSARY OR APPROPRIATE IN ORDER TO REALIZE ON THE
COLLATERAL OR TO OTHERWISE ENFORCE THE BANK'S RIGHTS AGAINST THE BORROWER OR ITS
PROPERTY.

BORROWER AND BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE
OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY
CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER
CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS
AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL.

      12 GENERAL PROVISIONS

      12.1 SUCCESSORS AND ASSIGNS. This Agreement binds and is for the benefit
of the successors and permitted assigns of each party. Borrower may not assign
this Agreement or any rights or Obligations under it without Bank's prior
written consent which may be granted or withheld in Bank's discretion. Bank has
the right, without the consent of or notice to Borrower, to sell, transfer,
negotiate, or grant participation in all or any part of, or any interest in,
Bank's obligations, rights and benefits under this Agreement, the Loan Documents
or any related agreement.

      12.2 INDEMNIFICATION. Borrower hereby indemnifies, defends and holds the
Bank and its directors, officers, employees and agents harmless against: (a) all
obligations, demands, claims, and liabilities asserted by any other party or
Person in connection with the transactions contemplated by the Loan Documents;
and (b) all losses or Bank Expenses incurred, or paid by Bank from, following,
or consequential to transactions between Bank and

                                      -11-
<PAGE>

Borrower (including reasonable attorneys' fees and expenses), except for losses
caused by Bank's gross negligence or willful misconduct.

      12.3 RIGHT OF SET-OFF. Borrower hereby grants to Bank, a lien, security
interest and right of setoff as security for all Obligations to Bank, whether
now existing or hereafter arising upon and against all deposits, credits,
collateral and property, now or hereafter in the possession, custody,
safekeeping or control of Bank or any entity under the control of the Bank
(including a Bank subsidiary) or in transit to any of them. At any time after
the occurrence and during the continuance of an Event of Default, without demand
or notice, Bank may set off the same or any part thereof and apply the same to
any liability or obligation of Borrower even though unmatured and regardless of
the adequacy of any other collateral securing the Obligations. ANY AND ALL
RIGHTS TO REQUIRE BANK TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY
OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS RIGHT OF
SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF THE BORROWER
ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED.

      12.4 TIME OF ESSENCE. Time is of the essence for the performance of all
Obligations in this Agreement.

      12.5 SEVERABILITY OF PROVISION. Each provision of this Agreement is
severable from every other provision in determining the enforceability of any
provision.

      12.6 AMENDMENTS IN WRITING; INTEGRATION. All amendments to this Agreement
must be in writing signed by both Bank and Borrower. This Agreement and the Loan
Documents represent the entire agreement about this subject matter, and
supersede prior negotiations or agreements. All prior agreements,
understandings, representations, warranties, and negotiations between the
parties about the subject matter of this Agreement and the Loan Documents merge
into this Agreement and the Loan Documents.

      12.7 COUNTERPARTS. This Agreement may be executed in any number of
counterparts and by different parties on separate counterparts, each of which,
when executed and delivered, are an original, and all taken together, constitute
one Agreement.

      12.8 SURVIVAL. All covenants, representations and warranties made in this
Agreement continue in full force while any Obligations remain outstanding. The
obligation of Borrower in Section 12.2 to indemnify Bank shall survive until the
statute of limitations with respect to such claim or cause of action shall have
run.

      12.9 CONFIDENTIALITY. In handling any confidential information, Bank shall
exercise the same degree of care that it exercises for its own proprietary
information, but disclosure of information may be made: (i) to Bank's
subsidiaries or affiliates in connection with their business with Borrower; (ii)
to prospective transferees or purchasers of any interest in the Credit
Extensions (provided, however, Bank shall use commercially reasonable efforts in
obtaining such prospective transferee's or purchaser's agreement to the terms of
this provision); (iii) as required by law, regulation, subpoena, or other order,
(iv) as required in connection with Bank's examination or audit; and (v) as Bank
considers appropriate in exercising remedies under this Agreement. Confidential
information does not include information that either: (a) is in the public
domain or in Bank's possession when disclosed to Bank, or becomes part of the
public domain after disclosure to Bank; or (b) is disclosed to Bank by a third
party, if Bank does not know that the third party is prohibited from disclosing
the information.

      12.10 ATTORNEYS' FEES, COSTS AND EXPENSES. In any action or proceeding
between Borrower and Bank arising out of the Loan Documents, the prevailing
party will be entitled to recover its reasonable attorneys' fees and other
reasonable costs and expenses incurred, in addition to any other relief to which
it may be entitled.

      13 DEFINITIONS

      13.1 DEFINITIONS. In this Agreement:

      "ACCOUNTS" are all existing and later arising accounts, contract rights,
and other obligations owed Borrower in connection with its sale or lease of
goods (including licensing software and other technology) or provision of
services, all credit insurance, guaranties, other security and all merchandise
returned or reclaimed by

                                      -12-
<PAGE>

Borrower and Borrower's Books relating to any of the foregoing, as such
definition may be amended from time to time according to the Code.

      "AFFILIATE" is a Person that owns or controls directly or indirectly the
Person, any Person that controls or is controlled by or is under common control
with the Person, and each of that Person's senior executive officers, directors,
partners and, for any Person that is a limited liability company, that Person's
managers and members.

      "BANK EXPENSES" are all audit fees and expenses and reasonable costs or
expenses (including reasonable attorneys' fees and expenses) for preparing,
negotiating, administering, defending and enforcing the Loan Documents
(including appeals or Insolvency Proceedings).

      "BORROWER'S BOOKS" are all Borrower's books and records including ledgers,
records regarding Borrower's assets or liabilities, the Collateral, business
operations or financial condition and all computer programs or storage or any
equipment containing the information.

      "BRIDGE LOAN" is a Bridge Loan Advance or Bridge Loan Advances of up to
Three Million Dollars ($3,000,000.00).

      "BRIDGE LOAN ADVANCE" is defined in Section 2.1.1.

      "BRIDGE LOAN MATURITY DATE" is the earlier to occur of: (x) fifteen (15)
days after the Capitalization Event, or (y) July 31, 2005.

      "BUSINESS DAY" is any day that is not a Saturday, Sunday or a day on which
the Bank is closed.

      "CAPITALIZATION EVENT" is receipt by the Borrower of gross proceeds in the
amount of Ten Million Dollars ($10,000,000.00) for the issuance of equity in a
private placement transaction, after the Closing Date.

      "CLOSING DATE" is the date of this Agreement.

      "CODE" is the Uniform Commercial Code as adopted in California, as amended
and as may be amended and in effect from time to time.

      "COLLATERAL" is any and all properties, rights and assets of the Borrower
granted by the Borrower to Bank or arising under the Code, now, or in the
future, in which the Borrower obtains an interest, or the power to transfer
rights, in the property described on EXHIBIT A.

      "CONTINGENT OBLIGATION" is, for any Person, any direct or indirect
liability, contingent or not, of that Person for (i) any indebtedness, lease,
dividend, letter of credit or other obligation of another such as an obligation
directly or indirectly guaranteed, endorsed, co-made, discounted or sold with
recourse by that Person, or for which that Person is directly or indirectly
liable; (ii) any obligations for undrawn letters of credit for the account of
that Person; and (iii) all obligations from any interest rate, currency or
commodity swap agreement, interest rate cap or collar agreement, or other
agreement or arrangement designated to protect a Person against fluctuation in
interest rates, currency exchange rates or commodity prices; but "Contingent
Obligation" does not include endorsements in the ordinary course of business.
The amount of a Contingent Obligation is the stated or determined amount of the
primary obligation for which the Contingent Obligation is made or, if not
determinable, the maximum reasonably anticipated liability for it determined by
the Person in good faith; but the amount may not exceed the maximum of the
obligations under any guarantee or other support arrangement.

      "COPYRIGHTS" are all copyright rights, applications or registrations and
like protections in each work or authorship or derivative work, whether
published or not (whether or not it is a trade secret) now or later existing,
created, acquired or held.

      "CREDIT EXTENSION" is each Bridge Loan Advance or any other extension of
credit by Bank for Borrower's benefit.

                                      -13-
<PAGE>

      "EQUIPMENT" is all present and future machinery, equipment, tenant
improvements, furniture, fixtures, vehicles, tools, parts and attachments in
which Borrower has any interest.

      "ERISA" is the Employment Retirement Income Security Act of 1974, and its
regulations.

      "GAAP" is generally accepted accounting principles.

      "INDEBTEDNESS" is (a) indebtedness for borrowed money or the deferred
price of property or services, such as reimbursement and other obligations for
surety bonds and letters of credit, (b) obligations evidenced by notes, bonds,
debentures or similar instruments, (c) capital lease obligations and (d)
Contingent Obligations.

      "INSOLVENCY PROCEEDING" is any proceeding by or against any Person under
the United States Bankruptcy Code, or any other bankruptcy or insolvency law,
including assignments for the benefit of creditors, compositions, extensions
generally with its creditors, or proceedings seeking reorganization,
arrangement, or other relief.

      "INTELLECTUAL PROPERTY" is:

                  (a) Copyrights, Trademarks, Patents, and Mask Works including
            amendments, renewals, extensions and all licenses or other rights to
            use and all license fees and royalties from the use;

                  (b) Any trade secrets and any Intellectual Property rights in
            computer software and computer software products now or later
            existing, created, acquired or held;

                  (c) All design rights which may be available to Borrower now
            or later created, acquired or held;

                  (d) Any claims for damages (past, present or future) for
            infringement of any of the rights above, with the right, but not the
            obligation, to sue and collect damages for use or infringement of
            the intellectual property rights above.

All proceeds and products of the foregoing, including all insurance, indemnity
or warranty payments.

      "INVENTORY" is present and future inventory in which Borrower has any
interest, including merchandise, raw materials, parts, supplies, packing and
shipping materials, work in process and finished products intended for sale or
lease or to be furnished under a contract of service, of every kind and
description now or later owned by or in the custody or possession, actual or
constructive, of Borrower, including inventory temporarily out of its custody or
possession or in transit and including returns on any accounts or other proceeds
(including insurance proceeds) from the sale or disposition of any of the
foregoing and any documents of title.

      "INVESTMENT" is any beneficial ownership of (including stock, partnership
interest or other securities) any Person, or any loan, advance or capital
contribution to any Person.

      "IP AGREEMENT" is a certain Intellectual Property Security Agreement
executed and delivered by Borrower to Bank.

      "LIEN" is a mortgage, lien, deed of trust, charge, pledge, security
interest or other encumbrance.

      "LOAN DOCUMENTS" are, collectively, this Agreement, any note, or notes or
guaranties executed by Borrower or Guarantor, and any other present or future
agreement between Borrower and/or for the benefit of Bank in connection with
this Agreement, all as amended, extended or restated.

      "MASK WORKS" are all mask works or similar rights available for the
protection of semiconductor chips, now owned or later acquired.

                                      -14-
<PAGE>

      "MATERIAL ADVERSE CHANGE " is: (i) A material impairment in the perfection
or priority of Bank's security interest in the Collateral or in the value of
such Collateral; (ii) a material adverse change in the business, operations, or
condition (financial or otherwise) of the Borrower; or (iii) a material
impairment of the prospect of repayment of any portion of the Obligations.

      "OBLIGATIONS" are debts, principal, interest, Bank Expenses and other
amounts Borrower owes Bank now or later, including letters of credit, cash
management services, and foreign exchange contracts, if any, and including
interest accruing after Insolvency Proceedings begin and debts, liabilities, or
obligations of Borrower assigned to Bank.

      "PATENTS" are patents, patent applications and like protections, including
improvements, divisions, continuations, renewals, reissues, extensions and
continuations-in-part of the same.

      "PERMITTED INDEBTEDNESS" is:

                  (a) Borrower's indebtedness to Bank under this Agreement or
            the Loan Documents;

                  (b) Indebtedness existing on the Closing Date and shown on the
            Perfection Certificate;

                  (c) Indebtedness to Solexa in the maximum amount of Two
            Million Five Hundred Thousand Dollars ($2,500,000.00) plus interest
            accrued thereon, subject to a subordination agreement, acceptable to
            Bank;

                  (d) Subordinated Debt;

                  (e) Indebtedness to trade creditors incurred in the ordinary
            course of business; and

                  (f) Indebtedness secured by Permitted Liens; and

                  (g) Extensions, refinancings, modifications, amendments and
            restatements of any items of Permitted Indebtedness (a) through (f)
            above, provided that the principal amount thereof is not increased
            or the terms thereof are not modified to impose more burdensome
            terms upon Borrower or its Subsidiary, as the case may be.

      "PERMITTED INVESTMENTS" are:

                  (a) Investments shown on the Perfection Certificate and
            existing on the Closing Date; and

                  (b) (i) marketable direct obligations issued or
            unconditionally guaranteed by the United States or its agency or any
            state maturing within 1 year from its acquisition, (ii) commercial
            paper maturing no more than 1 year after its creation and having the
            highest rating from either Standard & Poor's Corporation or Moody's
            Investors Service, Inc., (iii) Bank's certificates of deposit issued
            maturing no more than 1 year after issue, and (iv) any other
            investments administered through the Bank;

      "PERMITTED LIENS" are:

                  (a) Liens existing on the Closing Date and shown on the
            Perfection Certificate or arising under this Agreement or other Loan
            Documents;

                  (b) Liens for taxes, fees, assessments or other government
            charges or levies, either not delinquent or being contested in good
            faith and for which Borrower maintains adequate reserves on its
            Books, if they have no priority over any of Bank's security
            interests;

                                      -15-
<PAGE>

                  (c) Purchase money Liens (i) on Equipment acquired or held by
            Borrower incurred for financing the acquisition of the Equipment
            securing no more than Two Hundred Thousand Dollars ($200,000.00), in
            the aggregate amount outstanding, or (ii) existing on equipment when
            acquired, if the Lien is confined to the property and improvements
            and the proceeds of the equipment;

                  (d) Leases or subleases and non-exclusive licenses or
            sublicenses granted in the ordinary course of Borrower's business,
            if the leases, subleases, licenses and sublicenses permit granting
            Bank a security interest; and

                  (e) Liens incurred in the extension, renewal or refinancing of
            the indebtedness secured by Liens described in (a) through (d), but
            any extension, renewal or replacement Lien must be limited to the
            property encumbered by the existing Lien and the principal amount of
            the indebtedness may not increase.

      "PERSON" is any individual, sole proprietorship, partnership, limited
liability company, joint venture, company, trust, unincorporated organization,
association, corporation, institution, public benefit corporation, firm, joint
stock company, estate, entity or government agency.

      "RESPONSIBLE OFFICER" is each of the Chief Executive Officer, President,
Chief Financial Officer and Controller of Borrower.

      "SUBORDINATED DEBT" is debt incurred by Borrower subordinated to
Borrower's debt to Bank (pursuant to a subordination agreement entered into
between the Bank, the Borrower and the subordinated creditor), on terms
acceptable to Bank.

      "SUBSIDIARY" is any Person, corporation, partnership, limited liability
company, joint venture, or any other business entity of which more than 50% of
the voting stock or other equity interests is owned or controlled, directly or
indirectly, by the Person or one or more Affiliates of the Person.

      "TRADEMARKS" are trademark and service mark rights, registered or not,
applications to register and registrations and like protections, and the entire
goodwill of the business of Borrower connected with the trademarks.

                                      -16-
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed under the laws of the State of California as of the date first above
written.

BORROWER:

LYNX THERAPEUTICS, INC.

By /s/ Mary L. Schramke
   -----------------------------------
Name: Mary L. Schramke
Title: Acting Chief Executive Officer

BANK:

SILICON VALLEY BANK

By /s/ Michael J. Hanewich
   -----------------------------------
Name: Michael J. Hanewich
Title: Senior Vice President Life Sciences

                                      S-1
<PAGE>

                                    EXHIBIT A

      The Collateral consists of all of Borrower's right, title and interest in
and to the following:

      All goods, equipment, inventory, contract rights or rights to payment of
money, leases, license agreements, franchise agreements, general intangibles
(including payment intangibles), accounts (including health-care receivables),
documents, instruments (including any promissory notes), chattel paper (whether
tangible or electronic), cash, deposit accounts, fixtures, letters of credit
rights (whether or not the letter of credit is evidenced by a writing),
commercial tort claims, securities, and all other investment property,
supporting obligations, and financial assets, whether now owned or hereafter
acquired, wherever located; and

      Any copyright rights, copyright applications, copyright registrations and
like protections in each work of authorship and derivative work, whether
published or unpublished, now owned or later acquired; any patents, trademarks,
service marks and applications therefor; trade styles, trade names, any trade
secret rights, including any rights to unpatented inventions, know-how,
operating manuals, license rights and agreements and confidential information,
now owned or hereafter acquired; or any claims for damages by way of any past,
present and future infringement of any of the foregoing; and

      All Borrower's books relating to the foregoing and any and all claims,
rights and interests in any of the above and all substitutions for, additions,
attachments, accessories, accessions and improvements to and replacements,
products, proceeds and insurance proceeds of any or all of the foregoing.

      Notwithstanding the foregoing, the Collateral shall not include more than
66% of the total combined voting power of all classes of stock entitled to vote
the shares of capital stock of any Subsidiary of Borrower not incorporated or
organized under the laws of one of the States or jurisdictions of the United
States.
<PAGE>

                                    EXHIBIT B
                        LOAN PAYMENT/ADVANCE REQUEST FORM
                DEADLINE FOR SAME DAY PROCESSING IS 12:00 P.S.T.

Fax To:  (617) 969-5965                                      Date:______________

LOAN PAYMENT:
                             Lynx Therapeutics, Inc.

<TABLE>
<S>                                                 <C>
From Account #________________________________      To Account #_______________________________________________
                     (Deposit Account #)                                        (Loan Account #)
Principal $____________________________________     and/or Interest $____________________________________
</TABLE>

All Borrower's representation and warranties in the Loan and Security Agreement
are true, correct and complete in all material respects on the date of the
telephone transfer request for an advance, but those representations and
warranties expressly referring to another date shall be true, correct and
complete in all material respects as of such date:

AUTHORIZED SIGNATURE:______________________         Phone Number:_______________

LOAN ADVANCE:

Complete Outgoing Wire Request section below if all or a portion of the funds
from this loan advance are for an outgoing wire.

<TABLE>
<S>                                                 <C>
From Account #________________________________      To Account #_______________________________________________
                     (Loan Account #)                                           (Deposit Account #)
Amount of Advance $___________________________
</TABLE>

All Borrower's representation and warranties in the Loan and Security Agreement
are true, correct and complete in all material respects on the date of the
telephone transfer request for an advance, but those representations and
warranties expressly referring to another date shall be true, correct and
complete in all material respects as of such date:

AUTHORIZED SIGNATURE: _________________________     Phone Number:_______________

OUTGOING WIRE REQUEST

COMPLETE ONLY IF ALL OR A PORTION OF FUNDS FROM THE LOAN ADVANCE ABOVE ARE TO BE
WIRED. Deadline for same day processing is 12:00 pm, P.S.T.

<TABLE>
<S>                                                 <C>
Beneficiary Name: _____________________________     Amount of Wire:$___________________________________________

Beneficiary Bank: ______________________________    Account Number: ___________________________________________

City and State: ________________________________

Beneficiary Bank Transit (ABA) #:_______________    Beneficiary Bank Code (Swift, Sort, Chip, etc.):___________
                                                                 (FOR INTERNATIONAL WIRE ONLY)

Intermediary Bank: _____________________________    Transit (ABA) #: __________________________________________

For Further Credit to:_________________________________________________________________________________________

Special Instruction:___________________________________________________________________________________________
</TABLE>

By signing below, I (we) acknowledge and agree that my (our) funds transfer
request shall be processed in accordance with and subject to the terms and
conditions set forth in the agreements(s) covering funds transfer service(s),
which agreements(s) were previously received and executed by me (us).

Authorized Signature: _______________ 2nd Signature (If Required):______________
Print Name/Title: ___________________ Print Name/Title:_________________________
Telephone #:_________________________ Telephone #:______________________________
<PAGE>

                                   EXHIBIT C
                             COMPLIANCE CERTIFICATE

TO:   SILICON VALLEY BANK
FROM: LYNX THERAPEUTICS, INC.

      The undersigned authorized officer of LYNX THERAPEUTICS, INC. certifies
that under the terms and conditions of the Loan and Security Agreement between
Borrower and Bank (the "Agreement"), (i) Borrower is in complete compliance for
the period ending _______________ with all required covenants except as noted
below and (ii) there are no Events of Default, and all representations and
warranties in the Agreement are true and correct in all material respects on
this date. Attached are the required documents supporting the certification. The
Officer certifies that these are prepared in accordance with Generally Accepted
Accounting Principles (GAAP) consistently applied from one period to the next
except as explained in an accompanying letter or footnotes. The Officer
acknowledges that no borrowings may be requested at any time or date of
determination that Borrower is not in compliance with any of the terms of the
Agreement, and that compliance is determined not just at the date this
certificate is delivered.

  .PLEASE INDICATE COMPLIANCE STATUS BY CIRCLING YES/NO UNDER "COMPLIES" COLUMN.

<TABLE>
<CAPTION>
          REPORTING COVENANT                                   REQUIRED                       COMPLIES
          ------------------                                   --------                       --------
<S>                                                  <C>                                      <C>
Monthly financial statements with CC                 Monthly within 30 days                   Yes   No
10-Q, 10-K and 8-K                                   Within 5 days after filing with SEC      Yes   No
</TABLE>

  NOTIFICATION OF REGISTRATION OF INTELLECTUAL PROPERTY

  The following Intellectual Property was registered after the Closing Date (if
  blank, read "None")

  ______________________________________________________________________________
  ______________________________________________________________________________

COMMENTS REGARDING EXCEPTIONS:  See Attached.
Sincerely,
_____________________________
SIGNATURE
_____________________________
TITLE
_____________________________
DATE

BANK USE ONLY
Received by: _____________________
                AUTHORIZED SIGNER
Date:      _______________________

Verified: ________________________
                AUTHORIZED SIGNER
Date:      _______________________

Compliance Status:   Yes     No

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