Document:

Amended and Restated CV Therapeutics, Inc. Long-Term Incentive Plan

 Exhibit 10.2 
 AMENDED AND RESTATED 
 CV THERAPEUTICS, INC. 
 LONG-TERM INCENTIVE PLAN 
 (Amended
effective as of December 31, 2007) 
 ARTICLE I. 
 Purpose 
 The purpose of this Amended and Restated CV Therapeutics, Inc. Long-Term Incentive Plan (the
“Plan”) is to provide specified benefits to a select group of management or highly compensated employees who contribute materially to the continued growth, development and future success of CV Therapeutics, Inc. a Delaware corporation, and
its subsidiaries, if any, that sponsor this Plan. This Plan shall be unfunded for tax purposes and for purposes of Title I of ERISA. 
 ARTICLE II. 
 DEFINITIONS 
 As used within this document, the following words and phrases have the meanings described in this Article II unless a different meaning is required by the context. Some of the words and phrases used in the Plan are not defined in this
Article II, but for convenience, are defined as they are introduced into the text. Any headings used are included for ease of reference only and are not to be construed so as to alter any of the terms of the Plan. 
 2.1 Base Salary. A Participant’s annual cash compensation relating to services performed during any calendar year, whether or not paid in
such calendar year or included on the Federal Income Tax form W-2 for such calendar year, excluding bonuses, commissions, overtime, fringe benefits, stock options, relocation expenses, incentive payments, non-monetary awards, directors fees and
other fees, automobile and other allowances paid to a Participant for employment services rendered (whether or not such allowances are included in the Participant’s gross income). 
 2.2 Beneficiary. An individual or entity designated by a Participant in accordance with Section 12.7. 
 2.3 Board or Board of Directors. The Board of Directors of the Corporation. 
 2.4 Bonus. Cash earnings awarded to a Participant as incentive compensation at the option of any Employer which may or may not occur during each
Plan Year. 
 2.5 Change in Control. The occurrence of any of the following: 
 (a) a sale of substantially all of the assets of the Corporation; 
 (b) a merger or consolidation in which the Corporation is not the surviving corporation (other than a merger or consolidation in which
shareholders immediately before the merger or consolidation have, immediately after the merger or consolidation, equal or greater stock voting power); 

 (c) a reverse merger in which the Corporation is the surviving corporation but the shares
of the Corporation’s common stock outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise (other than a reverse merger in which shareholders
immediately before the merger have, immediately after the merger, greater stock voting power); or 
 (d) any transaction or
series of related transactions in which in excess of fifty percent (50%) of the Corporation’s voting power is transferred. 
 Notwithstanding the foregoing, an event shall not constitute a Change in Control unless such event is a change in ownership or effective control of the Corporation or a change in the ownership of a substantial portion of the assets of the
Corporation, within the meaning of Code Section 409A(a)(2)(A)(v) and any regulations promulgated thereunder. 
 2.6 Code. The
Internal Revenue Code of 1986, as amended. Reference to a section of the Code shall include that section and any comparable section or sections of any future legislation that amends, supplements or supersedes such section. 
 2.7 Committee. The Compensation Committee of the Board of Directors. 
 2.8 Contribution Account. The account established for a Participant pursuant to Section 5.1 of the Plan, which account shall reflect the
contributions made by him or her or on his or her behalf by his or her Employer under Section 4 and shall be credited (or charged, as the case may be) with the hypothetical or deemed investment earnings or losses determined pursuant to
Section 5.3, and charged with distributions made to or with respect to him or her. 
 2.9 Corporation. CV Therapeutics, Inc., a
Delaware corporation. 
 2.10 Deferral Election. The election made by the Participant pursuant to Section 4.1 of the Plan.

 2.11 Deferral Period. The Plan Year, or in the case of a newly hired or promoted employee who becomes an Eligible Employee during a
Plan Year, the remaining portion of the Plan Year. 
 2.12 Disability. Any medically determinable mental or physical impairment, which
can be expected to result in death or to last for a continuous period of not less than twelve (12) months, which renders a Participant (i) unable to engage in any substantial gainful activity or (ii) eligible to receive income
replacement benefits for a period of not less than three (3) months under the Corporation’s accident and health plan, if any. 
 2.13 Effective Date. This Plan’s original effective date was May 1, 2003. As amended and restated, the Effective Date for this Plan is December 31, 2007. 
  

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 2.14 Eligible Employee. Any person who is an employee of any Employer and who is designated by the
Chief Executive Officer of the Corporation as being eligible to participate in the Plan. The Chief Executive Officer of the Corporation is automatically an Eligible Employee for purposes of the Plan. 
 2.15 Employer. The Corporation and/or any of its subsidiaries (now in existence or hereafter formed or acquired) that have been selected by the
Board to participate in the Plan and have adopted the Plan as a sponsor. 
 2.16 ERISA. The Employee Retirement Income Security Act of
1974, as amended. Reference to a section of ERISA shall include that section and any comparable section or sections of any future legislation that amends, supplements or supersedes such section. 
 2.17 IRS. The Internal Revenue Service. 
 2.18 Measurement Fund. An investment fund or funds selected by the Plan Administrator, in its sole discretion, from time to time. 
 2.19 Normal Retirement Age. Sixty-five (65) years. 
 2.20 Normal Retirement Date. The date on which a
Participant reaches Normal Retirement Age. 
 2.21 Participant. Any Eligible Employee (i) who is selected to participate in the
Plan, and (ii) who commences participation in the Plan. If required by the Plan Administrator, a Participant shall sign a Participant Agreement and Election Form and submit such form for acceptance by the Plan Administrator. 
 2.22 Participant Agreement and Election Form. The written agreement made by a Participant. Such written agreement shall be in a format designated
by the Plan Administrator. 
 2.23 Plan. The Amended and Restated CV Therapeutics, Inc. Long-Term Incentive Plan. 
 2.24 Plan Administrator. The Committee or such other persons to whom the Committee has delegated its duties as Plan Administrator. 
 2.25 Plan Year. The 12-month period beginning each January 1 and ending on the following December 31. 
 2.26 Specified Employee shall mean any Participant who is determined by the Company to be a “specified employee” within the meaning of
Code Section 409A(a)(2)(B)(i) and any regulations promulgated thereunder. 
 2.27 Trust. The agreement of trust between any
Employer(s) and the trustee under which the assets of the Plan are held, administered and managed, as amended from time to time. 
 2.28
Valuation Date. Each business day of the Plan Year. 
  

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 ARTICLE III. 
 ELIGIBILITY AND PARTICIPATION 
 3.1 Participation for Employer Contributions – Eligibility.
Participation in the Plan is open only to Eligible Employees. Upon being designated as an Eligible Employee by the Chief Executive Officer of the corporation, an employee shall be eligible to receive Employer contributions under Section 4.3 as
of the Effective Date. Any employee designated as an Eligible Employee by the Chief Executive Officer of the Corporation after the Effective Date shall automatically become eligible to receive Employer contributions under Section 4.3 as of the
date he or she is selected as an Eligible Employee. 
 3.2 Employee Deferrals Not Currently Permitted. Notwithstanding anything to the
Plan to the contrary, Base Salary and/or Bonus deferrals under the Plan by Eligible Employees are not permitted as of the Effective Date. The Board may, at any time or from time to time after the Effective Date, amend the Plan to permit Base Salary
and/or Bonus deferrals under the Plan. In the event of such Board action, any employee designated as an Eligible Employee by the Chief Executive Officer of the Corporation may become a Participant with respect to Base Salary and/or Bonus deferrals
under Sections 4.1 and 4.2 for the remaining portion of the Deferral Period (or other period specified by the Plan Administrator) for a Plan Year if he or she submits a properly completed Participant Agreement and Election Form to the Plan
Administrator prior to the date specified by the Plan Administrator in its discretion, which shall in no event be after the commencement of the remaining portion of the Deferral Period (or other period) for which such Participant Agreement and
Deferral Election is to be effective. 
 3.3 Participation – Subsequent Entry into Plan. Any employee designated as an Eligible
Employee by the Chief Executive Officer of the Corporation who does not elect to participate with respect to Base Salary and/or Bonus deferrals under Sections 4.1 and 4.2 at the time of such designation as set forth in Section 3.2 shall remain
eligible to become a Participant with respect to Base Salary and/or Bonus deferrals in subsequent Plan Years as long as he or she continues his or her status as an Eligible Employee. In such event, the Eligible Employee may become a Participant with
respect to Base Salary and/or Bonus deferrals under Sections 4.1 and 4.2 by submitting a properly executed Participant Agreement and Election Form prior to January 1 of the Plan Year for which it is effective. 
 ARTICLE IV. 
 CONTRIBUTIONS 
 4.1 Deferral Election. Provided that Base Salary and/or Bonus deferrals under the Plan are permitted under Section 3.2, before the first day
of each Plan Year, an Eligible Employee may file with the Plan Administrator a Deferral Election Form indicating the amount of Base Salary and/or Bonus deferrals for that Plan Year. An Eligible Employee shall not be obligated to make a Deferral
Election for any Plan Year. After a Plan Year commences, such Deferral Election shall be irrevocable and shall continue for the entire Plan Year and subsequent years except that it shall terminate upon the execution and timely submission of a newly
completed Deferral Election Form or termination of employment. 
  

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 4.2 Maximum Deferral Election. Provided that Base Salary and/or Bonus deferrals under the Plan are
permitted under Section 3.2, an Eligible Employee may elect to defer such portion of his or her Base Salary and/or Bonus earned during the corresponding Deferral Period as determined by the Plan Administrator from time to time. A deferral
Election may be automatically reduced if the Plan Administrator determines that such action is necessary to meet Federal or State tax withholding obligations. 
 4.3 Employer Contributions. For any specified period, the Corporation shall contribute such aggregate amount to the Plan in the form of Employer contributions as is determined by the Chief Executive Officer of
the Corporation and approved by the Board or the Committee. The Chief Executive Officer of the Corporation shall allocate such aggregate amount among the Eligible Employees’ Contribution Accounts; provided, however, that the
Committee shall make such allocation with respect to the Contribution Account of the Chief Executive Officer of the Corporation. The amount so credited to an Eligible Employee’s Contribution Account may be smaller or larger than the amount
credited to any other Eligible Employee’s Contribution Account, and the amount credited to any Eligible Employee’s Contribution Account for any specified period may be zero, even though one or more other Eligible Employees receive an
Employer contribution for that period under this Section 4.3. An Employer’s Contribution under this Section 4.3, if any, shall be credited as of such date (or dates) as may be specified by the Plan Administrator in its sole
discretion. If an Eligible Employee is not employed by an Employer as of the date on which an Employer’s contributions is credited, his or her contribution amount under this Section 4.3 shall be zero. An Employer may condition its
crediting of any amount to an Eligible Employee’s Contribution Account upon the Eligible Employee’s execution and submission to the Plan Administrator of a Participant Agreement and Election Form. 
 ARTICLE V. 
 ACCOUNTS 
 5.1 Contribution Accounts. Solely for recordkeeping purposes, the Plan Administrator shall establish a Contribution Account for each Participant.
A Participant’s Contribution Account shall be credited with the contributions made by him or her or on his or her behalf by his or her Employer under Section 4 and shall be credited (or charged, as the case may be) with the hypothetical or
deemed investment earnings and losses determined pursuant to Section 5.3, and charged with distributions made to or with respect to him or her. 
 5.2 Crediting of Contribution Accounts. Base Salary contributions under Section 4.1 shall be credited to a Participant’s Contribution Account as of the date on which such contributions were withheld
from his or her Base Salary. Bonus contributions under Section 4.1 shall be credited to a Participant’s Contribution Account as of the date on which the contribution would have otherwise been paid in cash. Employer Contributions under
Section 4.3 shall be credited to the Participant’s Contribution Account on the date (or dates) specified by the Plan Administrator in its sole discretion. Any distribution with respect to a Contribution Account shall be charged to that
Contribution Account as of the date such payment is made by the Employer or the trustee of the Trust which may be established for the Plan. 
  

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 5.3 Earning Credits or Losses. Amounts credited to a Contribution Account shall be credited with
deemed earnings and/or losses, including deemed net realized and unrealized gains and losses, based on hypothetical investment elections made by the Participant with respect to his or her Contribution Account, on a form designated by the Plan
Administrator, from among the Measurement Funds and pursuant to investment procedures adopted by the Plan Administrator in its sole discretion, from time to time. The performance of each Measurement Fund (either positive or negative) shall be
determined by the Plan Administrator, in its sole discretion, based on the performance of the Measurement Funds themselves. Participants’ hypothetical investment elections and the Measurement Funds are to be used for measurement purposes only,
and the allocation of a Participant’s Contribution Account balance thereto or the crediting or debiting of amounts to a Participant’s Contribution Account shall not be considered or construed in any manner as an actual investment of his or
her Contribution Account balance in any such Measurement Fund. 
 5.4 Hypothetical Nature of Accounts. The Plan constitutes a mere
promise by the Employer to make benefit payments in the future. Any Contribution Account established for a Participant under this Article V shall be hypothetical in nature and shall be maintained for recordkeeping purposes only, so that any
contributions can be credited and so that deemed investment earnings and losses on such amounts can be credited (or charged, as the case may be). Neither the Plan nor any of the Contribution Accounts (or subaccounts) shall hold any actual funds or
assets. The right of any individual or entity to receive one or more payments under the Plan shall be an unsecured claim against the general assets of his or her Employer. Any liability of an Employer to any Participant, former Participant, or
Beneficiary with respect to a right to payment shall be based solely upon contractual obligations created by the Plan. The Corporation, the Board of Directors, the Committee, any Employer and any individual or entity shall not be deemed to be a
trustee of any amounts to be paid under the Plan. Nothing contained in the Plan, and no action taken pursuant to its provisions, shall create or be construed to create a trust of any kind, or a fiduciary relationship, between the Corporation and an
Employer and a Participant, former Participant, Beneficiary, or any other individual or entity. An Employer may, in its sole discretion, establish a Trust as a vehicle in which to place funds with respect to this Plan. Neither the Corporation nor
any Employer in any way guarantees any Participant’s Contribution Account against loss or depreciation, whether caused by poor investment performance, insolvency of a deemed investment or by any other event or occurrence. In no event shall any
employee, officer, director, or stockholder of the Corporation or any Employer be liable to any individual or entity on account of any claim arising by reason of the Plan provisions or any instrument or instruments implementing its provisions, or
for the failure of any Participant, Beneficiary or other individual or entity to be entitled to any particular tax consequences with respect to the Plan or any credit or payment thereunder. 
 5.5 Statement of Contribution Accounts. The Plan Administrator shall provide from time to time each Participant statements setting forth the value
of the Contribution Account maintained for such Participant. 
  

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 ARTICLE VI. 
 VESTING 
 Employer contributions credited to a Participant’s Contribution Account under
Section 4.3 of the Plan and any deemed investment earnings and losses attributable to these contributions shall become vested or nonforfeitable in accordance with the following schedule: 
 (a) Ten percent (10%) of each Employer contribution shall vest on the one year anniversary of the date such Employer contribution was credited to
such Participant’s Contribution Account under Section 4.3 of the Plan; 
 (b) Twenty percent (20%) of each Employer
contribution shall vest on the two year anniversary of the date such Employer contribution was credited to such Participant’s Contribution Account under Section 4.3 of the Plan (for an aggregate total of thirty percent (30%) vested to
date); and 
 (c) Seventy percent (70%) of each Employer contribution shall vest on the three year anniversary of the date such Employer
contribution was credited to such Participant’s Contribution Account under Section 4.3 of the Plan (for an aggregate total of one hundred percent (100%) vested to date). 
 In addition, a Participant shall be one hundred percent (100%) vested in the Employer’s contributions, including any deemed investment earnings
and losses attributable to these contributions, immediately prior to the effective date of a Change in Control or immediately upon his or her death or Disability while he or she is actively employed by an Employer. In the event of a
Participant’s termination of employment, other than by reason of his or her death or Disability, prior to the date on which all Employer contributions in such Participant’s Contribution Account have vested pursuant to this Article VI, the
unvested portion of such Employer contributions shall be forfeited and no Employer or the Plan shall be liable for the payment of such unvested amounts under the Plan to such Participant. Any amounts credited to a Participant’s Contribution
Account by his or her Employer on his or her behalf which are forfeited by such Participant pursuant to the proceeding sentence shall cease to be liabilities of the Employer or the Plan and such amounts shall be immediately debited from the
Participant’s Contribution Account and credited to such Employer. 
 ARTICLE VII. 
 BENEFITS 
 7.1 Retirement. Unless benefits have already commenced pursuant to
another section of this Article VII, a Participant shall begin receipt of the vested amount credited to his or her Contribution Account as of the Valuation Date coinciding with his or her Normal Retirement Date. Payment of any amount under this
Section shall commence within thirty (30) days of the Participant’s attainment of Normal Retirement Age and in accordance with the payment method elected by the Participant on his or her Participant Agreement and Election Form; provided
that if no payment method has been elected, payments shall be made in the form of a single lump sum. 
  

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 7.2 Disability. If a Participant suffers a Disability while employed with an Employer and before
he or she is entitled to benefits under this Article, he or she shall receive the amount credited to his or her Contribution Account as of the Valuation Date coinciding with the Date on which the Participant is determined to have suffered a
Disability (after giving effect to any accelerated vesting as a result of the Participant’s Disability pursuant to Article VI). Payment of any amount under this Section shall commence within thirty (30) days of when the Plan Administrator
determines the existence of the Participant’s Disability and be in accordance with the payment method elected by the Participant on his or her Participant Agreement and Election Form; provided that if no payment method has been elected,
payments shall be made in the form of a single lump sum. 
 7.3 Pre-Retirement Survivor Benefit. If a Participant dies before becoming
entitled to benefits under this Article, the Beneficiary or Beneficiaries designed under Section 12.7, shall receive in a single lump sum, a Pre-Retirement Survivor Benefit equal to the amount credited to the Participant’s Contribution
Account as of the Valuation Date coinciding with the date of the Participant’s death (after giving effect to any accelerated vesting as a result of the Participant’s death pursuant to Article VI). Payment of any amount under this Section
shall be made within thirty (30) days of the Participant’s death, or if later, within 30 days of when the Plan Administrator receives notification of or otherwise confirms the Participant’s death. 
 7.4 Post-Retirement Survivor Benefit. If a Participant dies after benefits have commenced, but prior to receiving complete payment of benefits
under this Article, the Beneficiary or Beneficiaries designated under Section 12.7, shall receive in a single lump sum the vested amount credited to the Participant’s Contribution Account as of the Valuation Date coinciding with the date
of the Participant’s death (after giving effect to any accelerated vesting as a result of the Participant’s death pursuant to Article VI). Payment of any amount under this Section shall be made within thirty (30) days of the
Participant’s death, or if later, within 30 days of when the Plan Administrator receives notification of or otherwise confirms the Participant’s death. 
 7.5 Termination. If a Participant has a separation from service with the Corporation within the meaning of Code Section 409A(a)(2)(A)(i) and any regulations promulgated thereunder (a “Separation from
Service”) for any reason other than death or Disability in either case before he or she becomes entitled to receive benefits by reason of any of other Sections in this Article VII or under Article VIII, he or she shall receive in a single lump
sum the vested amount credited to his or her Contribution Account as of the Valuation Date coinciding with the date on which his or her employment terminates. Subject to Section 7.6, payment of any amount under this Section shall be made within
thirty (30) days of when the Participant’s Separation from Service has occurred. 
 7.6 Specified Employees. Notwithstanding
any contrary provision in the Plan, if a Participant is a Specified Employee as of the date of his or her Separation from Service, his or her distributions on account of such Separation from Service shall commence no earlier than six (6) months
after the date of the Participant’s Separation from Service. 
  

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 7.7 Change in Control. In the event of a Change in Control, a Participant shall receive in a
single lump sum the vested amount credited to his or her Contribution Account as of the Valuation Date coinciding with the effective date of such Change in Control (after giving effect to any accelerated vesting as a result of the Change in Control
pursuant to Article VI). Payment of any amount under this Section shall be made immediately prior to the effective date of such Change in Control or, in the discretion of the Plan Administrator, within thirty (30) days after the Change in
Control. In the event of a Change in Control, a Participant shall receive his or her Contribution Account according to this Section 7.6 and without regard to any other payment method designated in Article VII or as elected on his or her
Participant Agreement and Election Form. 
 7.8 Payment Methods. Unless otherwise provided in this Article VII, a Participant may
elect to receive payment of the amount credited to his or her Contribution Account in a single lump sum or in five (5), or ten (10) annual installments. This election must be made on the Participant Agreement and Election Form for the
corresponding Plan Year and in no event later than thirty (30) days after the date that Employer Contributions subject to such Participant Agreement and Election Form have been credited to a Participant’s Contribution Account by the
Corporation, and at least one(1) year before any portion of such contribution may become vested and nonforfeitable. Any installment payments shall be paid annually on the first practicable day after the distributions are scheduled to commence. Each
installment payment shall be determined by multiplying the Contribution Account Balance by a fraction, the numerator of which is one and the denominator of which is the number of remaining installment payments. A Participant may modify the date on
which any such amounts are to be distributed or form of distribution or revoke a previous election with respect thereto by submitting a new Participant Agreement and Election Form; provided that any such modification or revocation shall not be given
any effect until at least one (1) year after the date on which the new election is made and only if (i) such new Election Form is submitted to and accepted by the Plan Administrator in its sole discretion at least one (1) year prior
to the scheduled payout date of the distribution to be modified or revoked and (ii) any new payout designated in such form results in the commencement of distributions at least five (5) years later than the scheduled commencement date of
the distribution election that is modified. 
 ARTICLE VIII. 
 IN-SERVICE DISTRIBUTIONS 
 8.1 Election of
In-Service Distributions. A Participant may elect in each Deferral Period, for that particular Deferral Election or Employer contribution, to receive in the future an in-service distribution from the vested portion of his or her Contribution
Account. Such Deferral Election shall state the percentage or flat dollar amount and date on which such in-service distribution is to be paid. Each election shall state the date on which such in-service distribution is to be paid; provided that such
date is not earlier than one (1) year from January 1st of the Plan Year following the year of said election. For example: The earliest
distribution date for the initial Plan Year ending December 31, 2003 would be January 1, 2005. This is calculated using January 1, 2004 as the “January 1st of the Plan Year following” plus one (1) year. A Participant may modify the date on which any such in-service distribution is to be paid or revoke a previous election with respect thereto by submitting a
new Participant Agreement and Election form, provided, that any such modification or revocation does not result in the acceleration of distribution of such amounts; is not effective earlier than one (1) year from the date such modification or
revocation is submitted and results in the commencement of distributions at least five (5) years later than the scheduled commencement date of the distribution election that is modified. 
  

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 8.2 Payment of In-Service Distributions. All in-service distributions shall be made within thirty
(30) days of the date stated on the Election Form. Distributions shall be in the form of a single lump sum payment. 
 8.3
Termination Prior to In-Service Distribution Date. Notwithstanding a Participant’s election of an in-service distribution, in the event a Participant’s employment terminates for any reason pursuant to Section VII of the Plan
Document and prior to such Participant receiving any in-service distribution, the Participant shall receive his or her vested Contribution Account balance according to the payment method designated in Article VII or as elected on his or her
Participant Agreement and Election Form. 
 8.4 Installment Payments. Other than with respect to the initial installment payment of
any distribution hereunder (which shall be paid as soon as practicable after the event giving rise to such distribution), installment payments of amounts distributable hereunder shall be made no later than January 31 of each year during which
such installment amounts are payable. 
 ARTICLE IX. 
 TRANSITION PERIOD ELECTIONS 
 Notwithstanding anything in the Plan to the contrary, prior to
December 31, 2007 a Participant may modify his or her payment time and method elections under Articles VII and VII of the Plan with respect to all or any portion of his or her Contribution Account, provided that such modification may apply only
to amounts that would not otherwise be payable in 2007 and may not cause an amount to be paid in 2007 that would not otherwise be payable in 2007. Such modifications shall be made pursuant to an election agreement in a form acceptable to the Plan
Administrator. 
 ARTICLE X. 
 ESTABLISHMENT OF TRUST 
 10.1 Establishment of Trust. An Employer may establish a Trust for the Plan. If established, all
benefits payable under this Plan to a Participant shall be paid directly by the Employer from the Trust. To the extent that such benefits are not paid from the Trust, the benefits shall be paid from the general assets of the Employer. The Trust, if
any, shall be an irrevocable grantor trust which conforms to the terms of the model trust as described in IRS Revenue Procedure 92-64, I.R.B. 1992-33. The assets of the Trust are subject to the claims of each Employer’s creditors in the event
of its insolvency. Except as provided under the Trust agreement, neither the Corporation nor an Employer shall be obligated to set aside, earmark or escrow any funds or other assets to satisfy its obligations under this Plan, and the Participant
and/or his or her designated Beneficiaries shall not have any property interest in any specific assets of the Corporation or an Employer other than the unsecured right to receive payments from the Employer, as provided in this Plan. 
  

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 ARTICLE XI. 
 PLAN ADMINISTRATION 
 11.1 Plan Administration. The Plan shall be administered by the Plan
Administrator, and such Plan Administrator may designate an agent (or agents) to perform the recordkeeping duties. The Plan Administrator shall construe and interpret the Plan, including disputed and doubtful terms and provisions and, in its sole
discretion, decide all questions of eligibility and determine the amount, manner and time of payment of benefits under the Plan. The determinations and interpretations of the Plan Administrator shall be consistently and uniformly applied to all
Participants and Beneficiaries, including but not limited to interpretations and determinations of amounts due under this Plan, and shall be final and binding on all parties. The Plan at all times shall be interpreted and administered as an unfunded
deferred compensation plan, and no provision of the Plan shall be interpreted so as to give any Participant or Beneficiary any right in any asset of the Corporation or an employer which is a right greater than the right of a general unsecured
creditor of the Corporation or such Employer. 
 ARTICLE XII. 
 AMENDMENT AND TERMINATION 
 12.1 Amendment and Termination. The Committee reserves the right to amend
or alter, retroactively or prospectively, or discontinue this Plan at any time. Such action may be taken in writing by any officer of the Committee who has been duly authorized by the Committee to perform acts of such kind. However, no such
amendment shall deprive any Participant or Beneficiary of any portion of any benefit which would have been payable had the Participant’s employment with the Employer terminated on the effective date of such amendment or termination.
Notwithstanding the provisions of this Article to the contrary, the Committee may amend the Plan at any time, in any manner, if the Committee determines any such amendment is required to ensure that the Plan is characterized as providing deferred
compensation for a select group of management or highly compensated employees and as described in ERISA Sections 201(2), 301(a)(3) and 401(a)(1) or to otherwise conform the Plan to the provisions of any applicable law including ERISA and the Code.

 ARTICLE XIII. 
 GENERAL
PROVISIONS 
 13.1 Status of Plan. The Plan is intended to be a plan that is not qualified within the meaning of Code
Section 401(a) and that “is unfunded and is maintained by an employer primarily for the purpose of providing deferred compensation for a select group of management or highly compensated employees” within the meaning of ERISA Sections
201(2), 301(a)(3) and 401(a)(1). The Plan shall be administered and interpreted to the extent possible in a manner consistent with that intent. 
 13.2 Good Faith Payment. Any payment made in good faith in accordance with provisions of the Plan shall be a complete discharge of any liability for the making of such payment under the provisions of this Plan. 
  

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 13.3 No Right to Employment. This Plan does not constitute a contract of employment, and
participation in the Plan shall not give any Participant the right to be retained in the employment of an Employer. 
 13.4 Binding
Effect. The provisions of this Plan shall be binding upon the Corporation, each Employer and their respective successors and assigns and upon every Participant and his or her heirs, Beneficiaries, estates and legal representatives. 

13.5 Participant Change of Address. Each Participant entitled to benefits shall file with the Plan Administrator, in writing, any change of
post office address. Any check representing payment and any communication addressed to a Participant or a former Participant at this last address filed wit the Plan Administrator, or if no such address has been filed, then at his or her last address
as indicated on the Employer’s records, shall be binding on such Participant for all purposes of the Plan, and neither the Plan Administrator nor the Employer or other payer shall be obligated to search for or ascertain the location of any such
Participant. If the Plan Administrator is in doubt as to the address of any Participant entitled to benefits or as to whether benefit payments are being received by a Participant, it shall, by registered mail addressed to such Participant at his or
her last know address, notify such Participant that: 
 (a) All unmailed and future Plan payments shall be withheld until
Participant provides the Plan Administrator with evidence of such Participant’s continued life and proper mailing address; and 
 (b) Participant’s right to any Plan payment shall, at the option of the Plan Administrator, be canceled forever, if, at the expiration of five (5) years from the date of such mailing, such Participant shall not have provided the
Plan Administrator with evidence of his or her continued life and proper mailing address. 
 13.6 Notices. Each Participant shall
furnish to the Plan Administrator any information the Plan Administrator deems necessary for purposes of administering the Plan, and the payment provisions of the Plan are conditional upon the Participant furnishing promptly such true and complete
information as the Plan Administrator may request. Each Participant shall submit proof of his or her age when required by the Plan Administrator. The Plan Administrator shall, if such proof of age is not submitted as required, used such information
as is deemed by it to be reliable, regardless of the lack of proof, or the misstatement of the age of individuals entitled to benefits. Any notice or information which, according to the terms of the Plan or requirements of the Plan Administrator,
must be filed with the Plan Administrator, shall be deemed so filed if addressed and either delivered in person or mailed to and received by the Plan Administrator, in care of the Corporation at the Corporation’s principal place of business.

 13.7 Designation of Beneficiary. Each Participant shall designate, by name, on Beneficiary designation forms provided by the Plan
Administrator, the Beneficiary(ies) who shall receive any benefits which might be payable after such Participant’s death. A Beneficiary designation may be changed or revoked without such Beneficiary’s consent at any time or from time to
time in the manner as provided by the Plan Administrator, and the Plan Administrator shall have no duty to notify any individual or entity designated as a Beneficiary of any change in such designation which might affect such individual or
entity’s present or future rights. If the 

  

 12 

 
designated Beneficiary does not survive the Participant, all amounts which would have been paid to such deceased Beneficiary shall be paid to any remaining
Beneficiary in that class of beneficiaries, unless the Participant has designated that such amounts go to the lineal descendants of the deceased Beneficiary. If none of the designated primary Beneficiaries survive the Participant, and the
Participant did not designate that payments would be payable to such Beneficiary’s lineal descendants, amounts otherwise payable to such Beneficiaries shall be paid to any successor Beneficiaries designated by the Participant, or if none, to
the Participant’s spouse, or, if the Participant was not married at the time of death, the Participant’s estate. 
 No Participant
shall designate more than five (5) simultaneous Beneficiaries, and if more than one (1) Beneficiary is named, Participant shall designate the share to be received by each Beneficiary. Despite the limitation on five (5) Beneficiaries,
a Participant may designate more than five (5) Beneficiaries provided such Beneficiaries are the surviving spouse and children of the Participant. If a Participant designated alternative, successor, or contingent beneficiaries, such Participant
shall specify the shares, terms and conditions upon which amounts shall be paid to such multiple, alternative, successor or contingent Beneficiaries. Except as provided otherwise in this Section, any payment made under this Plan after the death of a
Participant shall be made only to the Beneficiary or Beneficiaries designated pursuant to this Section. 
 13.8 Nonalienation of
Benefits. The interests of Participants and their Beneficiaries under this Plan are not subject to the claims of their creditors and may not be voluntarily or involuntarily sold, transferred, alienated, assigned, pledged, anticipated, or
encumbered, attached or garnished. Any attempt by a Participant, his or her Beneficiary, or any other individual or entity to sell, transfer, alienated, assign, pledge, anticipate, encumber, attach, garnish, change or otherwise dispose of any right
to benefits payable shall be void. The Employer may cancel and refuse to pay any portion of a benefit which is sold, transferred, alienated, assigned, pledged, anticipated, encumbered, attached or garnished. The benefits which a Participant may
assure under this Plan are not subject to the terms of any Qualified Domestic Relations Order (as that term is defined in Section 414(p) of the Code) with respect to any Participant, and the Plan Administrator, Board, Committee, Corporation and
Employer shall not be required to comply with the terms of such order in connection with this Plan. Notwithstanding the foregoing, the withholding of taxes from Plan payments, the recovery of Plan overpayments of benefits made to a Participant or
Beneficiary, the transfer of Plan benefit rights from the Plan to another plan, or the direct deposit of Plan payments to an account in a financial institution (if not actually a part of an arrangement constituting an assignment or alienation) shall
not be construed as an assignment or alienation under this Section 13.8 and shall be permitted under the Plan. 
 13.9 Claims.

 (a) Application for Benefits. Applications for benefits and inquires concerning the Plan (or concerning present or
future rights to benefits under the Plan) shall be submitted to the Plan Administrator in writing. An application for Benefits shall be submitted on the prescribed form and shall be signed by the Participant or, in the case of a benefit payable
after his or her death, by his or her Beneficiary. 
  

 13 

 (b) Denial of Application. If a claim is wholly or partially denied, the Plan
Administrator shall provide the claimant with a notice of denial, written in a manner calculated to be understood by the claimant, setting forth: 
 (i) The specific reason for such denial; 
 (ii) Specific references to the Plan provisions on
which the denial is based; 
 (iii) A description of any additional material or information necessary for the claimant to
perfect the claim with an explanation of why such material or information is necessary; and 
 (iv) Appropriate information as
to the steps to be taken if the claimant wishes to submit his or her claim for review, including the time limits applicable to such procedures, and a statement of the claimant’s right to bring a civil action under Section 502(a) of ERISA
following an adverse decision upon review. 
 The notice of denial shall be given within a reasonable time period but no later than ninety
(90) days after the claim is filed, unless special circumstances require an extension of time for processing the claim. If such extension is required, written notice shall be furnished to the claimant within ninety (90) days of the date
the claim was filed stating the special circumstances requiring an extension of time and the date by which a decision on the claim can be expected, which shall be no more than one hundred eighty (180) days from the date the claim was filed.

 (c) Review Panel. The Plan Administrator may from time to time appoint a review panel that may consist of two
(2) or more individuals who may, but need not, be Employees of the Corporation (the “Review Panel”). If no such Review Panel is named, the Corporation shall be deemed to be the Review Panel for purposes of this
Section 13.9. The Review Panel shall be the named fiduciary that has the authority to act with respect to any appeal from a denial of benefits or a determination of benefit rights. 
 (d) Request for Review. The claimant and/or his or her representative may request review, in writing of a denied claim and may:

 (i) Request upon written application to the Review Panel to review and/or copy free of charge, pertinent Plan documents,
records, and other information relevant to the claimant’s claim; and 
 (ii) Submit issues and submit documents, records
and other information relating to the claim; 
 provided that such appeal specified each of claimant’s contentions, the grounds on which each is based,
all facts in support of the request, and any other matters which the claimant deems pertinent, and is made within sixty (60) days of the date the claimant receives notification of the denied claim. The decision on review shall be made by the
Review Panel, which may, in its discretion, hold a hearing on the denied claim. The review shall take into account all comments, documents, records and other information submitted by the claimant relating to the claim, without regard to whether such
information was submitted or considered in the initial benefit claim determination. 
  

 14 

 (e) Decision on Review. Upon receipt of a request for review, the Review Panel
shall provide written notification of its decision to the claimant stating the specific reasons and referencing specific Plan provisions on which its decision is based, written in a manner calculated to be understood by the claimant and including a
statement that the claimant is entitled to receive upon request and free of charge reasonable access to and copies of all documents, records and other information relevant to the claimant’s claim for benefits, as well as a statement of the
claimant’s rights to bring an action under Section 502(a) of ERISA. The decision will ordinarily be made within sixty (60) days after receiving the written request for review unless special circumstances require an extension for
processing the review. If such an extension is required, the Review Panel shall notify the claimant of such special circumstances and of the date, no later than one hundred twenty (120) days after the original date the review was requested, on
which the Review Panel will notify the claimant of its decision. In any event, the decision on review will be delivered to the claimant as soon as possible, but not later than five (5) days after the claim determination is made. 
 (f) No Legal Recourse Until Claims Procedure Exhausted. In the event of any dispute over benefits under this Plan, all remedies
available to the disputing individual under this Section 12.9 must be exhausted before legal recourse of any type is sought. 
 13.10
Tax Withholding. 
 (a) Annual Deferral Amounts. For each Plan Year in which a Participant is making a Base
Salary and/or Bonus deferral, the Participant’s Employer shall be entitled to require payment by the Participant of any sums required by federal, state or local tax law to be withheld with respect to the deferral, in amounts in a manner to be
determined in the sole discretion of the Employer. 
 (b) Employer Contributions. When a Participant becomes vested in
a portion of his or her Employer contributions, the Participant’s Employer shall be entitled to require payment of any sums required by federal, state or local tax law to be withheld with respect to the vesting of such Employer contributions,
in amounts and in a manner to be determined in the sole discretion of the Employer. 
 (c) Distributions. The
Participant’s Employer, or the trustee of the Trust, shall withhold from any payments made to a Participant under this Plan all federal, state and local income, employment and other taxes required to be withheld by the Employer, or the trustee
of the Trust, in connection with such payments, in amounts and in a manner to be determined in the sole discretion of the Employer and the trustee of the Trust. 
 (d) Satisfaction of Tax Obligations. The Plan Administrator, in its sole discretion, may allow a Participant to pay to his or her
Employer any amounts required to be withheld by the Employer in connection with the Plan in cash, by deduction of such amounts from other compensation payable to the Participants, or to have such amounts withheld from his or her deferrals, vested
Contribution Account balance or distributions. 
  

 15 

 13.11 Governing Law. To the extent not superseded by the laws of the United States, the laws of
the State of California (other than the conflicts of law provisions thereof) shall be controlling in all matters relating to this Plan. 
 13.12 Severability. In the event any provision of this Plan shall be held illegal or invalid for any reason, such illegality or invalidity shall not affect the remaining provisions of the Plan, and the Plan shall be interpreted and
enforced as if such illegal and invalid provisions had never been set forth. 
 13.13 Code Section 409A. Except as may be
permitted under applicable regulations or binding Treasury Department guidance, under no circumstances may the distribution of any amounts hereunder (1) occur earlier than the occurrence of an event set forth in Code
Section 409A(a)(2)(A)(i) through (vi) or (2) be accelerated in violation of Code Section 409A(a)(3). In the event any provision of the Plan, or the application thereof, is or becomes inconsistent with Code Section 409A and
any regulations promulgated thereunder, such provision shall be void or unenforceable or in the sole discretion of the Plan Administrator shall be deemed amended to comply with Code Section 409A and any regulations promulgated thereunder. The
other provisions of the Plan shall remain in full force and effect. 
 IN WITNESS WHEREOF, CV Therapeutics, Inc. has signed this Plan
document to be effective as of December 31, 2007. 
  

			
	 CV THERAPEUTICS, INC., a Delaware
 corporation

		
	By:	 	/S/ LOUIS G. LANGE, M.D., PH.D.
	Title:	 	Chairman and Chief Executive Officer

  

 16CV Therapeutics, Inc. Change in Control Plan

 Exhibit 10.3 
 CV THERAPEUTICS, INC. 
 CHANGE
IN CONTROL PLAN WITH RESPECT TO OPTIONS AND SEVERANCE 
 (AND SUMMARY PLAN DESCRIPTION) 
 (Amended effective as of December 31, 2007) 
 This Amended and Restated Change in Control Plan
with Respect to Options and Severance (the “Plan”) sets forth the terms of severance benefits for certain employees in the event of a Change in Control of CV Therapeutics, Inc. (together with any successor to substantially all of
its business, stock or assets, the “Company”) or the termination of employment with the Company under the circumstances described below after a Change in Control. 
 The Plan is an employee welfare benefit plan subject to the Employee Retirement Income Security Act of 1974, as amended (“ERISA”). This
Plan document is also the summary plan description of the Plan. References in the Plan to “You” or “Your” are references to an employee of the Company. 
 General Eligibility. You shall only be eligible for benefits under this Plan if, immediately prior to the effective date of a Change in Control,
you are a full-time employee of the Company; provided, however, that any employee who holds a title of Vice President, Senior Vice President or Chief Executive Officer as of such date shall not be eligible for benefits under this Plan,
and any employee who is a party to any individual severance agreement approved by the board of directors of the Company as of such date shall not be eligible for benefits under this Plan. 
 Treatment of Options upon Change in Control. No later than five (5) business days before the effective date of a Change in Control, your
then-outstanding Options shall, automatically and without further action by the Company, become one hundred percent (100%) vested and exercisable. 
 Enhanced Severance. Upon a Triggering Event following a Change in Control, you shall receive the severance benefits set forth in subsections (a) through (c) below: 
 (a) Base Salary. You will receive, as severance, your base salary for a period (the “Severance Period”) equal to
(i) three (3) months, plus, but only if and to the extent applicable to you, (ii) an additional two (2) weeks for each full year of your service as an employee of the Company through the date of the Triggering Event;
provided, however, that in no event shall such Severance Period exceed twelve (12) months. Such severance amount shall be paid in cash in a lump sum within thirty (30) days following the Triggering Event or upon your timely
providing the Company with an irrevocable release of claims in accordance with Section 4, if later, and shall be subject to all required tax withholding. For purposes of determining your salary severance benefits, your base salary will be equal
to your base salary as in effect during the last regularly scheduled payroll period immediately preceding the Triggering Event. 
  

 1 

 (b) Bonus. The Company shall pay you an amount equal to one hundred and fifty
percent (150%) of the annual bonus paid to you in the year immediately preceding the effective date of the Change in Control. Such severance amount shall be paid in cash in a lump sum within thirty (30) days following the Triggering Event
and shall be subject to all required tax withholding. 
 (c) Health Benefits. Provided that you elect continued
coverage under the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company shall pay the premiums of your group health insurance coverage, including coverage for your eligible dependents, for the
Severance Period; provided, however, that the Company shall pay premiums for your eligible dependents only for coverage for which those eligible dependents were enrolled immediately prior to the Triggering Event. No premium payments will be
made following the effective date of your coverage by a health insurance plan of a subsequent employer. For the balance of the period that you are entitled to coverage under federal COBRA law, if any, you will be entitled to maintain such coverage
at your own expense. 
 Release Prior To Payment Of Benefits. Upon the occurrence of a Triggering Event, and prior to the payment of any
benefits under this Plan, you will be required to execute a release (the “Release”) in the form attached hereto and incorporated herein as Appendix A or Appendix B, as applicable. Such Release shall specifically relate to all of your
rights and claims in existence at the time of such execution and shall confirm your obligations under the Company’s standard form of proprietary information and inventions agreement. It is understood that, as specified in the applicable
Release, you will have a certain number of calendar days to consider whether to execute such Release. In the event you do not provide the Company with a signed irrevocable copy of the Release within 2-1/2 months after a Triggering Event, no benefits
shall be payable under this Plan to you. 
 Parachute Payments.  
 (a) If any payment or benefit you would receive under this Plan, when combined with any other payment or benefit you receive pursuant to
the termination of your employment with the Company (“Payment”), would (i) constitute a “parachute payment” within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the
“Code”), and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment shall be either (x) the full amount of such Payment or
(y) such lesser amount (with cash payments being reduced before stock option compensation) as would result in no portion of the Payment being subject to the Excise Tax, whichever of the foregoing amounts, taking into account the applicable
federal, state and local employment taxes, income taxes, and the Excise Tax, results in your receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise
Tax. 
 (b) All determinations required to be made under this Section 5, including whether and to what extent the
Payments shall be reduced and the assumptions to be utilized in arriving at such determination, shall be made by the nationally recognized certified public accounting firm used by the Company immediately prior to the effective date of the Change in
Control or, if such firm declines to serve, such other nationally recognized certified public accounting firm as may be designated by the Company (the “Accounting Firm”). The Accounting Firm shall provide detailed supporting
calculations both to you and the Company at such time as is requested by the Company. All fees and expenses of the Accounting Firm shall 

  

 2 

 
be borne solely by the Company. Any determination by the Accounting Firm shall be binding upon you and the Company. For purposes of making the calculations
required by this Section 5, the Accounting Firm may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good-faith interpretations concerning the application of Sections 280G and 4999 of the
Code. 
 Effective Date of Plan/Amendment. This Plan shall be effective as of December 31, 2002. The Board of Directors of the
Company shall have the power to amend or terminate this Plan from time to time in its discretion and for any reason (or no reason) prior to the occurrence of a Change in Control. 
 Claims Procedures. 
 Normally, you do not need to present a formal claim to receive benefits payable under this Plan. 
 If any person
(the “Claimant”) believes that benefits are being denied improperly, that the Plan is not being operated properly, that fiduciaries of the Plan have breached their duties, or that the Claimant’s legal rights are being violated
with respect to the Plan, the Claimant must file a formal claim, in writing, with the Plan Administrator. This requirement applies to all claims that any Claimant has with respect to the Plan, including claims against fiduciaries and former
fiduciaries, except to the extent the Plan Administrator determines, in its sole discretion, that it does not have the power to grant all relief reasonably being sought by the Claimant. 
 A formal claim must be filed within ninety (90) days after the date the Claimant first knew or should have known of the facts on
which the claim is based, unless the Plan Administrator in writing consents otherwise. The Plan Administrator shall provide a Claimant, on request, with a copy of the claims procedures established under subsection (d). 
 The Plan Administrator has adopted procedures for considering claims (which are set forth in Appendix C), which it may amend from
time to time, as it sees fit. These procedures shall comply with all applicable legal requirements. These procedures may provide that final and binding arbitration shall be the ultimate means of contesting a denied claim (even if the Plan
Administrator or its delegates have failed to follow the prescribed procedures with respect to the claim). The right to receive benefits under this Plan is contingent on a Claimant using the prescribed claims procedures to resolve any claim.

 Plan Administration. 
 The Plan shall be administered by the Compensation Committee of the Company’s Board of Directors and/or its delegate which shall be one or more senior officers of the Company (the “Plan
Administrator”). The Plan Administrator is responsible for the general administration and management of the Plan and shall have all powers and duties necessary to fulfill its responsibilities, including, but not limited to, the discretion
to interpret and apply the Plan and to determine all questions relating to eligibility for benefits. The Plan shall be interpreted in accordance with its terms and their intended meanings. However, the Plan Administrator and all Plan fiduciaries
shall have the discretion to interpret or construe 

  

 3 

 
ambiguous, unclear, or implied (but omitted) terms in any fashion they deem to be appropriate in their sole discretion, and to make any findings of fact
needed in the administration of the Plan. The validity of any such interpretation, construction, decision, or finding of fact shall not be given de novo review if challenged in court, by arbitration, or in any other forum, and shall be upheld unless
clearly arbitrary or capricious. 
 All actions taken and all determinations made in good faith by the Plan Administrator or
by Plan fiduciaries will be final and binding on all persons claiming any interest in or under the Plan. To the extent the Plan Administrator or any Plan fiduciary has been granted discretionary authority under the Plan, the Plan
Administrator’s or Plan fiduciary’s prior exercise of such authority shall not obligate it to exercise its authority in a like fashion thereafter. 
 If, due to errors in drafting, any Plan provision does not accurately reflect its intended meaning, as demonstrated by consistent
interpretations or other evidence of intent, or as determined by the Plan Administrator in its sole discretion, the provision shall be considered ambiguous and shall be interpreted by the Plan Administrator and all Plan fiduciaries in a fashion
consistent with its intent, as determined in the sole discretion of the Plan Administrator. The Plan Administrator shall amend the Plan retroactively to cure any such ambiguity. 
 No Plan fiduciary shall have the authority to answer questions about any pending or final business decision of the Company or any
affiliate that has not been officially announced, to make disclosures about such matters, or even to discuss them, and no person shall rely on any unauthorized, unofficial disclosure. Thus, before a decision is officially announced, no fiduciary is
authorized to tell any person, for example, that he or she will or will not be laid off or that the Company will or will not offer exit incentives in the future. Nothing in this subsection shall preclude any fiduciary from fully participating in the
consideration, making, or official announcement of any business decision. 
 This Section may not be invoked by any person to
require the Plan to be interpreted in a manner inconsistent with its interpretation by the Plan Administrator or other Plan fiduciaries. 
 Superseding Plan. This Plan (i) shall be the only plan with respect to which benefits may be provided to you as a result of any Triggering Event and (ii) shall supersede any other plan previously adopted by the Company with
respect to severance benefits payable to you or the acceleration of your Options as a result of a Change in Control. Any of your rights hereunder shall be in addition to any rights you may otherwise have under benefit plans or agreements of the
Company (other than severance plans or agreements) to which you are a party or in which you are a participant, including, but not limited to, any Company-sponsored employee benefit plans and stock options plans. 
 Limitation On Employee Rights. This Plan shall not give any employee the right to be retained in the service of the Company, nor
shall it interfere with or restrict the right of the Company to discharge or retire the employee. 
 No Third-Party
Beneficiaries. This Plan shall not give any rights or remedies to any person other than covered employees and the Company. 
  

 4 

 Governing Law. This Plan is a welfare plan subject to ERISA and it shall be
interpreted, administered, and enforced in accordance with that law. To the extent that state law is applicable, the statutes and common law of the State of California, excluding any that mandate the use of another jurisdiction’s laws, shall
apply. 
 Miscellaneous. Where the context so indicates, the singular will include the plural and vice versa. Titles are
provided herein for convenience only and are not to serve as a basis for interpretation or construction of the Plan. Unless the context clearly indicates to the contrary, a reference to a statute or document shall be construed as referring to any
subsequently enacted, adopted, or executed counterpart. 
 Notice. For purposes of this Plan, notices and all other communications
provided for in this Plan shall be in writing and shall be deemed to have been duly given when delivered or mailed by United States certified or registered mail, return receipt requested, postage prepaid, addressed to the Company at its primary
office location and to an employee at such employee’s last known address as listed on the Company’s records, provided that all notices to the Company shall be directed to the attention of its Secretary, or to such other address as either
party may have furnished to the other in writing in accordance herewith, except that notice of change of address shall be effective only upon receipt. 
 Additional Information. As a participant in the Plan, you are entitled to certain rights and protections under ERISA, as described in Appendix D. 
 Definitions. For purposes of this Plan, the following terms shall have the following meanings: 
 (a) “Cause” means that, in the reasonable determination of the Company, you: 
 (i) have committed an act that materially injures the business of the Company; 
 (ii) have refused or failed to follow lawful and reasonable directions of the Board of Directors of the Company or the appropriate
individual to whom you report; 
 (iii) have willfully or habitually neglected your duties for the Company; or 
 (iv) have been convicted of a felony involving moral turpitude that is likely to inflict or has inflicted material injury on the business
of the Company. 
 Notwithstanding the foregoing, Cause shall not exist based on conduct described in clause (ii) or clause
(iii) unless the conduct described in such clause has not been cured within fifteen (15) days following your receipt of written notice from the Company specifying the particulars of the conduct constituting Cause. 
 (b) “Change in Control” means: 
 (i) a sale of substantially all of the assets of the Company; 
  

 5 

 (ii) a merger or consolidation in which the Company is not the surviving corporation
(other than a merger or consolidation in which shareholders immediately before the merger or consolidation have, immediately after the merger or consolidation, equal or greater stock voting power); 
 (iii) a reverse merger in which the Company is the surviving corporation but the shares of the Company’s common stock outstanding
immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise (other than a reverse merger in which shareholders immediately before the merger have, immediately after
the merger, greater stock voting power); or 
 (iv) any transaction or series of related transactions in which in excess of
50% of the Company’s voting power is transferred. 
 (c) “Option” shall mean any option to purchase
shares of Common Stock of the Company outstanding at the time of a Change in Control and any substitute option, if applicable, if such option has been assumed in a Change in Control, regardless of whether such option has been granted as of the date
hereof under the Company’s employee stock option plans, including, but not limited to, the following plans: 
 (i) The CV
Therapeutics, Inc. 2000 Equity Incentive Plan; 
 (ii) The CV Therapeutics, Inc. 2000 Non-Statutory Incentive Plan; and

 (iii) The CV Therapeutics, Inc. 1994 Equity Incentive Plan. 
 (d) “Triggering Event” shall mean you have a “separation from service” within the meaning of
Section 409A(a)(2)(A)(i) of the Code from the Company (a “Separation from Service”) without Cause within thirteen (13) months following the effective date of a Change in Control; provided, however, that if
you have a Separation from Service following the effective date of a Change in Control but intend to, and do, accept employment with the Company’s successor or acquirer within ninety (90) days after the effective date of the Change in
Control, no Triggering Event shall occur; and provided, further, however, that if you have a Separation from Service without Cause by the successor or acquirer within the thirteen (13) months following the effective date of
the Change in Control, a Triggering Event shall occur. The termination of your employment as a result of your death or disability will not be deemed to be a termination without Cause for purposes of this definition. 
  

 6 

 APPENDIX A 
 RELEASE 
 (INDIVIDUAL TERMINATION) 
 Certain capitalized terms used in this Release are defined in the Change in Control Plan with Respect to Options and Severance (the
“Plan”) which I have executed and of which this Release is a part. I have been offered the opportunity to receive the severance benefits described in Section 3 of the Plan from the Company to which I otherwise would not be
entitled by executing the general release of claims set forth in this Release. 
 I hereby confirm my obligations under the Company’s
proprietary information and inventions agreement. 
 I acknowledge that I have read and understand Section 1542 of the California Civil
Code which reads as follows: “A general release does not extend to claims which the creditor does not know or suspect to exist in his favor at the time of executing the release, which if known by him must have materially affected his
settlement with the debtor.” I hereby expressly waive and relinquish all rights and benefits under that section and any law of any jurisdiction of similar effect with respect to my release of any claims I may have against the Company.

 Except as otherwise set forth in this Release, I hereby release, acquit and forever discharge the Company, its parents and subsidiaries,
and their officers, directors, agents, servants, employees, shareholders, successors, assigns and affiliates, of and from any and all claims, liabilities, demands, causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and unknown, suspected and unsuspected, disclosed and undisclosed (other than any claim for indemnification I may have as a result of any third party action against me based
on my employment with the Company), arising out of or in any way related to agreements, events, acts or conduct at any time prior to the date I execute this Release, including, but not limited to: all such claims and demands directly or indirectly
arising out of or in any way connected with my employment with the Company or the termination of that employment, including but not limited to, claims of intentional and negligent infliction of emotional distress, any and all tort claims for
personal injury, claims or demands related to salary, bonuses, commissions, stock, stock options, or any other ownership interests in the Company, vacation pay, fringe benefits, expense reimbursements, severance pay, or any other form of disputed
compensation; claims pursuant to any federal, state or local law or cause of action including, but not limited to, the federal Civil Rights Act of 1964, as amended; the federal Age Discrimination in Employment Act of 1967, as amended
(“ADEA”); the federal Employee Retirement Income Security Act of 1974, as amended; the federal Americans with Disabilities Act of 1990; the California Fair Employment and Housing Act, as amended; tort law; contract law; statutory
law; common law; wrongful discharge; discrimination; fraud; defamation; emotional distress; and breach of the implied covenant of good faith and fair dealing. 
  

 7 

 FOR EMPLOYEES AGE 40 OR OLDER ONLY: 
 I acknowledge that I am knowingly and voluntarily waiving and releasing any rights I may have under ADEA. I also acknowledge that the consideration given
under the Plan for the waiver and release in the preceding paragraph hereof is in addition to anything of value to which I was already entitled. I further acknowledge that I have been advised by this writing, as required by the ADEA, that:
(A) my waiver and release do not apply to any rights or claims that may arise on or after the date I execute this Release; (B) I have the right to consult with an attorney prior to executing this Release; (C) I have twenty-one
(21) days to consider this Release (although I may choose to voluntarily execute this Release earlier); (D) I have seven (7) days following the execution of this Release by the parties to revoke the Release; and (E) this Release
shall not be effective until the date upon which the revocation period has expired, which shall be the eighth day after this Release is executed by me. 
  

			
	[NAME OF EMPLOYEE]
	
	 
	Date:	 	 

  

 8 

 APPENDIX B 
 RELEASE 
 (GROUP TERMINATION) 
 Certain capitalized terms used in this Release are defined in the Change in Control Plan with Respect to Options and Severance (the
“Plan”) which I have executed and of which this Release is a part. I have been offered the opportunity to receive the severance benefits described in Section 3 of the Plan from the Company to which I otherwise would not be
entitled by executing the general release of claims set forth in this Release. 
 I hereby confirm my obligations under the Company’s
proprietary information and inventions agreement. 
 I acknowledge that I have read and understand Section 1542 of the California Civil
Code which reads as follows: “A general release does not extend to claims which the creditor does not know or suspect to exist in his favor at the time of executing the release, which if known by him must have materially affected his
settlement with the debtor.” I hereby expressly waive and relinquish all rights and benefits under that section and any law of any jurisdiction of similar effect with respect to my release of any claims I may have against the Company.

 Except as otherwise set forth in this Release, I hereby release, acquit and forever discharge the Company, its parents and subsidiaries,
and their officers, directors, agents, servants, employees, shareholders, successors, assigns and affiliates, of and from any and all claims, liabilities, demands, causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and unknown, suspected and unsuspected, disclosed and undisclosed (other than any claim for indemnification I may have as a result of any third party action against me based
on my employment with the Company), arising out of or in any way related to agreements, events, acts or conduct at any time prior to the date I execute this Release, including, but not limited to: all such claims and demands directly or indirectly
arising out of or in any way connected with my employment with the Company or the termination of that employment, including but not limited to, claims of intentional and negligent infliction of emotional distress, any and all tort claims for
personal injury, claims or demands related to salary, bonuses, commissions, stock, stock options, or any other ownership interests in the Company, vacation pay, fringe benefits, expense reimbursements, severance pay, or any other form of disputed
compensation; claims pursuant to any federal, state or local law or cause of action including, but not limited to, the federal Civil Rights Act of 1964, as amended; the federal Age Discrimination in Employment Act of 1967, as amended
(“ADEA”); the federal Employee Retirement Income Security Act of 1974, as amended; the federal Americans with Disabilities Act of 1990; the California Fair Employment and Housing Act, as amended; tort law; contract law; statutory
law; common law; wrongful discharge; discrimination; fraud; defamation; emotional distress; and breach of the implied covenant of good faith and fair dealing. 
  

 9 

 The attachment to this Release includes a listing of the ages and job titles of all employees of the
Company who are eligible to receive the severance benefits described in the Plan by signing a Release constituting a general release of all claims. 
 FOR EMPLOYEES AGE 40 OR OLDER ONLY: 
 I acknowledge that I am knowingly and voluntarily waiving and releasing any rights I
may have under ADEA. I also acknowledge that the consideration given under the Plan for the waiver and release in the preceding paragraph hereof is in addition to anything of value to which I was already entitled. I further acknowledge that I have
been advised by this writing, as required by the ADEA, that: (A) my waiver and release do not apply to any rights or claims that may arise on or after the date I execute this Release; (B) I have the right to consult with an attorney prior
to executing this Release; (C) I have forty-five (45) days to consider this Release (although I may choose to voluntarily execute this Release earlier); (D) I have seven (7) days following the execution of this Release by the
parties to revoke the Release; (E) this Release shall not be effective until the date upon which the revocation period has expired, which shall be the eighth day after this Release is executed by me; and (F) I have received with this
Release a detailed list of the job titles and ages of all employees who were terminated in this group termination and the ages of all employees of the Company in the same job classification or organizational unit who were not terminated. 

 

			
	[NAME OF EMPLOYEE]
	
	 
	Date:	 	 

  

 10 

 ATTACHMENT TO RELEASE 
 The following information is provided to comply with the Older Workers Benefit Protection Act. Capitalized terms used herein but not defined shall have
the meanings given them in the General Release to which this Attachment is attached. Attached are the ages of all employees of CV Therapeutics, Inc. (the “Company”) who are eligible to receive the severance benefits described in the
Change in Control Plan with Respect to Options and Severance (the “Plan”) by signing a Release constituting a general release of all claims: 
  

	 	(1)	The decisional unit is the Company. 

  

	 	(2)	The attachment includes a listing of the ages and job titles of all employees of the Company who are eligible to receive the severance benefits described in the Plan by signing a
Release constituting a general release of all claims. 

  

 11 

 JOB CLASSIFICATION AND AGE OF EMPLOYEES 
 ELIGIBLE FOR SEVERANCE BENEFITS 
  

					
	 Job Title
	  	 	  	 Age

	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 
	 	  		  	 

 APPENDIX C 
 DETAILED CLAIMS PROCEDURES 
  

	 	1.	Claims Procedure. 

 (a) Initial
Claims. All claims shall be presented to the Plan Administrator in writing. Within ninety (90) days after receiving a claim, a claims official appointed by the Plan Administrator shall consider the claim and issue his or her determination
thereon in writing. The claims official may extend the determination period for up to an additional ninety (90) days by giving the Claimant written notice. The initial claim determination period can be extended further with the consent of the
Claimant. Any claims that the Claimant does not pursue in good faith through the initial claims stage shall be treated as having been irrevocably waived. 
 (b) Claims Decisions. If the claim is granted, the benefits or relief the Claimant seeks shall be provided. If the claim is wholly or partially denied, the claims official shall, within ninety (90) days
(or a longer period, as described above), provide the Claimant with written notice of the denial, setting forth, in a manner calculated to be understood by the Claimant: (i) the specific reason or reasons for the denial; (ii) specific
references to the provisions on which the denial is based; (iii) a description of any additional material or information necessary for the Claimant to perfect the claim, together with an explanation of why the material or information is
necessary; and (iv) appropriate information as to the steps to be taken if the claimant wishes to submit his or her claim for review, including the time limits applicable to such procedures, and a statement of the claimant’s right to bring
a civil action under Section 502(a) of ERISA following an adverse decision upon review. If the Claimant can establish that the claims official has failed to respond to the claim in a timely manner, the Claimant may treat the claim as having
been denied by the claims official. 
 (c) Appeals of Denied Claims. Each Claimant shall have the opportunity to appeal
the claims official’s denial of a claim in writing to an appeals official appointed by the Plan Administrator (which may be a person, committee, or other entity). A Claimant must appeal a denied claim within sixty (60) days after receipt
of written notice of denial of the claim, or within sixty (60) days after it was due if the Claimant did not receive it by its due date. The Claimant (or his or her duly authorized representative) may review pertinent documents in connection
with the appeals proceeding and may present issues, comments and documents in writing relating to the claim. The review shall take into account all comments, documents, records and other information submitted by the Claimant relating to the claim,
without regard to whether such information was submitted or considered in the initial benefit claim determination. Any claims that the Claimant does not pursue in good faith through the appeals stage, such as by failing to file a timely appeal
request, shall be treated as having been irrevocably waived. 
 (d) Appeals Decisions. The decision by the appeals
official shall be made not later than sixty (60) days after the written appeal is received by the Plan Administrator, unless special circumstances require an extension of time, in which case a decision shall be rendered as soon as possible, but
not later than one hundred twenty (120) days after the appeal was filed, unless the Claimant agrees to a further extension of time. The appeal decision shall be in writing, shall be set forth in a manner calculated to be understood by the
Claimant, and shall 

  

 2 

 
include specific reasons for the decision, specific references to the provisions on which the decision is based, if applicable, a statement that the claimant
is entitled to receive upon request and free of charge reasonable access to and copies of all documents, records and other information relevant to the claimant’s claim for benefits, as well as a statement of the claimant’s right to bring
an action under Section 502(a) of ERISA. If a Claimant does not receive the appeal decision by the date it is due, the Claimant may deem his or her appeal to have been denied. 
 (e) Procedures. The Plan Administrator shall adopt procedures by which initial claims shall be considered and appeals shall be
resolved; different procedures may be established for different claims. All procedures shall be designed to afford a Claimant full and fair consideration of his or her claim. 
  

 3 

 APPENDIX D 
 ADDITIONAL INFORMATION 
 RIGHTS UNDER ERISA 
 As a participant in the Plan, you are entitled to certain rights and protections under ERISA. ERISA provides that all Plan participants will be entitled
to: 
 Receive Information About Your Plan and Benefits 
 1. Examine, without charge, at the Plan Administrator’s office and at certain Company offices, all Plan documents including collective bargaining
agreements, if any, and copies of all documents filed by the Plan with the U.S. Department of Labor, and available at the Public Disclosure Room of the Pension and Welfare Benefit Administration, such as annual reports and Plan descriptions.

 2. Obtain, upon written request to the Plan Administrator, copies of documents governing the operation of the Plan, including collective
bargaining agreements and copies of the latest annual report (Form 5500 Series) and updated summary plan description. The Plan Administrator may make a reasonable charge for the copies. 
 3. Obtain upon written request to the Plan Administrator information as to whether a particular employer or employer organization is a sponsor of the
Plan and the address of any employer or employer organization that is a plan sponsor. Your beneficiaries also have a right to obtain this information upon written request to the Plan Administrator. 
 4. Receive a summary of the Plan’s annual financial report. The Plan Administrator is required by law to furnish each participant with a copy of
this summary annual report. 
 5. Receive a written explanation of why a claim for benefits has been denied, in whole or in part, and a
review and reconsideration of the claim. 
 6. Continue health care coverage for yourself, spouse or dependent if there is a loss of coverage
as a result of a qualifying event. You or your dependents may have to pay for such coverage. Review this Plan and summary plan description on the rules governing your COBRA continuation coverage rights. 
 Prudent Actions by Plan Fiduciaries 
 In addition to creating rights for Plan participants, ERISA imposes duties upon the people who are responsible for the operation of the employee benefit plan. The people who operate your Plan, called “fiduciaries” of the Plan,
have a duty to do so prudently and in the interest of you and other Plan participants and beneficiaries. No one, including the Company, your union, or any other person, may fire you or otherwise discriminate against you in any way to prevent your
from obtaining a welfare benefit or exercising your right under ERISA. However, this rule neither guarantees continued employment, nor affects the Company’s right to terminate your employment for other reasons. 

 Enforce Your Rights 
 If your claim for a welfare benefit is denied or ignored, in whole or in part, you have a right to know why this was done, to obtain copies of documents
relating to the decision without charge, and to appeal any denial, all within certain time schedules. 
 Under ERISA, there are steps you can
take to enforce the above rights. For instance, if you request a copy of plan documents or the latest annual report from the Plan and do not receive them within thirty (30) days, you may file suit in a Federal court. In such a case, the court
may require the Plan Administrator to provide the materials and pay you up to $110 a day until you receive the materials, unless the materials were not sent because of reasons beyond the control of the Plan Administrator. If you have a claim for
benefits which is denied or ignored, in whole or in part, you may file suit in a state or Federal court. In addition, if you disagree with the Plan’s decision or lack thereof concerning the qualified status of a domestic relations order or a
medical child support order, you may file suit in Federal court. If it should happen that Plan fiduciaries misuse the Plan’s money, or if you are discriminated against for asserting your rights, you may seek assistance from the U.S. Department
of Labor, or you may file suit in a federal court. The court will decide who should pay court costs and legal fees. If you are successful, the court may order the person you have sued to pay these costs and fees. If you lose, the court may order you
to pay these costs and fees, for example, if it finds your claim is frivolous. 
 Assistance with Your Questions 
 If you have any questions about your Plan, you should contact the Plan Administrator. If you should have any questions about this statement or about your
rights under ERISA, or if you need assistance in obtaining documents from the Plan Administrator, you should contact the nearest office of the Pension and Welfare Benefits Administration, U. S. Department of Labor, listed in your telephone directory
or the Division of Technical Assistance and Inquires, Pension and Welfare Benefits Administration, U. S. Department of Labor, 200 Constitution Avenue N. W., Washington, D. C. 20210. You may also obtain certain publications about your rights and
responsibilities under ERISA by calling the publications hotline of the Pension and Welfare Benefits Administration. 
  

 2 

			
	ADMINISTRATIVE INFORMATION
		
	 Name of Plan:
	  	 The CV Therapeutics, Inc. Change in Control Plan with respect to Options and Severance

		
	 Plan Administrator:
	  	 Compensation Committee of the Board of Directors
  

CV Therapeutics, Inc.
3172 Porter Drive
Palo Alto, CA 94394
Tel: 650-384-8500
Fax: 650-858-0390

		
	 Type of Administration:
	  	 Self-Administered

		
	 Type of Plan:
	  	 Severance Pay Employee Welfare Benefit Plan

		
	 Employer Identification
Number:
	  	
 43-1570294

		
	 Direct Questions
Regarding the Plan to:
	  	
 General Counsel
  
 CV Therapeutics, Inc.
3172 Porter Drive
Palo Alto, CA 94394
Tel: 650-384-8500
Fax: 650-858-0390

		
	 Agent for Service of Legal
Process:
	  	
 General Counsel
CV Therapeutics, Inc.
3172 Porter Drive
Palo Alto, CA 94394
Tel:
650-384-8500
Fax: 650-858-0388
  
 Service of Legal Process may
also be made upon the Plan Administrator

		
	 Plan Year:
	  	 Calendar Year

		
	 Plan Number:
	  	 505

  

 3

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