Document:

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                                                                     EXHIBIT 4.1

                    AMENDMENT TO STOCKHOLDER RIGHTS AGREEMENT

         THIS AMENDMENT (this "AMENDMENT") is entered into as of July 15, 2003,
by and between, eXegenics Inc., a Delaware corporation (the "COMPANY"), and
American Stock Transfer & Trust Company, as Rights Agent (the "RIGHTS AGENT").

                                    RECITALS

         A. The Company and the Rights Agent are parties to a Rights Agreement
dated as of June 9, 2003 ( the "RIGHTS AGREEMENT").

         B. The Company, AVI BioPharma Inc., an Oregon corporation ("PARENT")
and eXegenics Acquisition, Inc., a Delaware corporation and a wholly owned
subsidiary of Parent ("ACQUISITION SUB"), intend to enter into an Agreement and
Plan of Merger (the "ACQUISITION AGREEMENT") pursuant to which, among other
things, (i) Acquisition Sub will commence an exchange offer in accordance with
the Securities Exchange Act of 1934, as amended, for all of the outstanding
shares of the common stock, par value $0.01 per share, of the Company (including
the Rights attached thereto) and all of the outstanding shares of Preferred
Stock, par value $0.01 per share of the Company (the "OFFER"), and (ii) if
Acquisition Sub acquires shares of the Company's capital stock in the Offer,
Acquisition Sub will merge with and into the Company (the "MERGER"), and the
Company will survive the Merger as a wholly owned subsidiary of Parent;

         C. On July 15, 2003, the Board of Directors of the Company determined
it is in the best interest of the Company's stockholders to amend the Rights
Agreement to render the Rights inapplicable to the Offer, the Merger and any of
the other transactions contemplated by the Acquisition Agreement, including,
without limitation, the execution and delivery of, and the consummation of the
transactions contemplated by, the Stockholder Agreements to be executed
concurrently with the execution of the Acquisition Agreement by certain
stockholders of the Company for the benefit of Parent and Acquisition Sub (the
"STOCKHOLDER AGREEMENTS") and (ii) certain other transactions involving Parent,
Acquisition Sub or another wholly-owned subsidiary of Parent; and

         D. The Company desires to amend the Rights Agreement in accordance with
Section 27 of the Rights Agreement.

                  Accordingly, the parties agree that:

         1. AMENDMENT TO DEFINITION OF "ACQUIRING PERSON" SET FORTH IN SECTION
1(a). The definition of "Acquiring Person" set forth in Section 1(a) of the
Rights Agreement is hereby amended by adding the following new paragraph at the
end of Section 1(a):

         "Notwithstanding anything in this Agreement that might otherwise be
deemed to the contrary, no Person will become an Acquiring Person solely by
reason of (i) the execution, delivery, amendment, supplement or performance of
the Agreement and Plan of Merger, dated as of July 16, 2003 (the "Acquisition
Agreement"), among the Company, AVI BioPharma, Inc., an Oregon corporation
("Parent") and eXegenics Acquisition, Inc., a Delaware corporation ("Acquisition
Sub"), or the execution, delivery, amendment, supplement or performance of any
of the stockholder agreements dated July 16, 2003 among certain stockholders of
the Company and Parent (the "Stockholder Agreements"), (ii) the commencement by
Parent, Acquisition Sub or any other Subsidiary of Parent of the Offer (as
defined in the Acquisition Agreement), (iii) the acquisition of any shares of
capital stock of the Company by Parent, Acquisition Sub or any other Subsidiary
of Parent pursuant to the Offer or the exercise by either Parent or Acquisition
Sub of the Common Top-Up Option

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(as defined in the Acquisition Agreement) or the Preferred Top-Up Option (as
defined in the Acquisition Agreement), (iv) the consummation of the Merger (as
defined in the Acquisition Agreement), or (v) the consummation of any of the
other transactions contemplated by the Acquisition Agreement or any of the
Stockholder Agreements; provided that any Person who (X) would be an Acquiring
Person but for this sentence and (Y) prior to the Acceptance Date, as that term
is defined in the Acquisition Agreement, becomes the Beneficial Owner of any
shares of Common Stock other than as contemplated by the Acquisition Agreement
or any of the Stockholders Agreements, shall be deemed an Acquiring Person."

         2. AMENDMENT TO DEFINITION OF "STOCK ACQUISITION DATE" SET FORTH IN
SECTION 1(jj). The definition of "Stock Acquisition Date" set forth in Section
1(jj) of the Rights Agreement is hereby amended by adding the following new
paragraph at the end of Section 1(jj):

         "Notwithstanding anything in this Agreement that might otherwise be
deemed to the contrary, a Stock Acquisition Date shall not be deemed to have
occurred solely by reason of (i) the execution, delivery, amendment, supplement
or performance of the Acquisition Agreement or the execution, delivery,
amendment, supplement or performance of any of the Stockholder Agreements, (ii)
the commencement by Parent, Acquisition Sub or any other Subsidiary of Parent of
the Offer, (iii) the acquisition of any shares of capital stock of the Company
by Parent, Acquisition Sub or any other Subsidiary of Parent pursuant to the
Offer or the exercise by either Parent or Acquisition Sub of the Common Top-Up
Option or the Preferred Top-Up Option, (iv) the consummation of the Merger, (v)
the consummation of any of the other transactions contemplated by the
Acquisition Agreement or any of the Stockholder Agreements, or (vi) the public
announcement of the execution, delivery, amendment, supplement or performance of
the Acquisition Agreement or the execution, delivery, amendment, supplement or
performance of any of the Stockholder Agreements."

         3. AMENDMENT TO DEFINITION OF "TRIGGERING EVENT" SET FORTH IN SECTION
1(nn). The definition of "Triggering Event" set forth in Section 1(nn) of the
Rights Agreement is hereby amended by adding the following new paragraph at the
end of Section 1(nn):

         "Notwithstanding anything in this Agreement that might otherwise be
deemed to the contrary, a Triggering Event shall not be deemed to have occurred
solely by reason of (i) the execution, delivery, amendment, supplement or
performance of the Acquisition Agreement or the execution, delivery, amendment,
supplement or performance of any of the Stockholder Agreements, (ii) the
commencement by Parent, Acquisition Sub or any other Subsidiary of Parent of the
Offer, (iii) the acquisition of any shares of capital stock of the Company by
Parent, Acquisition Sub or any other Subsidiary of Parent pursuant to the Offer
or the exercise by either Parent or Acquisition Sub of the Common Top-Up Option
or the Preferred Top-Up Option, (iv) the consummation of the Merger, (v) the
consummation of any of the other transactions contemplated by the Acquisition
Agreement or any of the Stockholder Agreements, or (iv) the public announcement
of the execution, delivery, amendment, supplement or performance of the
Acquisition Agreement or the execution, delivery, amendment, supplement or
performance of any of the Stockholder Agreements."

         4. AMENDMENT TO DEFINITION OF "FINAL EXPIRATION DATE" SET FORTH IN
SECTION 1(r). The definition of "Final Expiration Date" set forth in Section
1(r) of the Rights Agreement is hereby deleted in its entirety and replaced by
the following new Section 1(r):

         ""Final Expiration Date" shall mean the earlier of (i) the moment in
         time immediately prior to the Effective Time (as defined in the
         Acquisition Agreement) or (ii) the close of business on June 9, 2013."

         5. AMENDMENT TO SECTION 3(a) "ISSUE OF RIGHTS CERTIFICATES". Section
3(a) of the Rights Agreement is hereby amended by adding the following new
paragraph at the end of Section 3(a):

         "Notwithstanding anything in this Agreement that might otherwise be
deemed to the contrary, a Distribution Date shall not be deemed to have occurred
solely by reason of (i) the execution, delivery,

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amendment, supplement or performance of the Acquisition Agreement or the
execution, delivery, amendment, supplement or performance of any of the
Stockholder Agreements, (ii) the commencement by Parent, Acquisition Sub or any
other Subsidiary of Parent of the Offer, (iii) the acquisition of any shares of
capital stock of the Company by Parent, Acquisition Sub or any other Subsidiary
of Parent pursuant to the Offer or the exercise by either Parent or Acquisition
Sub of the Common Top-Up Option or the Preferred Top-Up Option, (iv) the
consummation of the Merger, (v) the consummation of any of the other
transactions contemplated by the Acquisition Agreement or any of the Stockholder
Agreements, or (iv) the public announcement of the execution, delivery,
amendment, supplement or performance of the Acquisition Agreement or the
execution, delivery, amendment, supplement or performance of any of the
Stockholder Agreements."

         6. MISCELLANEOUS. Except as set forth herein, the Rights Agreement
shall remain in full force and effect and shall be otherwise unaffected by this
Amendment. This Amendment shall be deemed to be a contract made under the laws
of the State of Delaware and for all purposes shall be governed by and construed
in accordance with the laws of such State applicable to contracts to be made and
performed entirely within such State. This Amendment may be executed in any
number of counterparts, each of such counterparts shall for all purposes be
deemed to be an original, and all such counterparts shall together constitute
but one and the same instrument. If any term, provision, covenant or restriction
of this Amendment is held by a court of competent jurisdiction or other
authority to be invalid, void or unenforceable, the remainder of the terms,
provisions, covenants and restrictions of this Amendment shall remain in full
force and effect and shall in no way be affected, impaired or invalidated.

                          (signature on following page)

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         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to
the Stockholder Rights Agreement to be duly executed and attested, all as of the
day and year first above written.

ATTEST:                                EXEGENICS INC.

By:                                    By:
         --------------------------             --------------------------------
         Name:                                  Name:
         Title:                                 Title

ATTEST:                                AMERICAN STOCK TRANSFER & TRUST
                                       COMPANY

By:                                    By:
         --------------------------             --------------------------------
         Name:                                  Name:
         Title:                                 Title:<PAGE>
\
                                                                    EXHIBIT 10.1

                            INDEMNIFICATION AGREEMENT

         This Indemnification Agreement is made as of this ____ day of
__________, ____, by and between eXegenics Inc. (f/k/a Cytoclonal Pharmaceutics,
Inc.), a Delaware corporation (the "COMPANY") and __________________________
("INDEMNITEE").

                                   WITNESSETH:

         WHEREAS, the Company, in order to induce Indemnitee to serve the
Company as a director, has agreed to provide Indemnitee with the benefits
contemplated by this Agreement;

         WHEREAS, as a result of the provision of such benefits Indemnitee has
agreed to serve as a director of the Company;

         WHEREAS, the By-laws of the Company and the Certificate of
Incorporation of the Company require the Company to indemnify its directors and
officers and others to the full extent permitted by law, and the Indemnitee has
agreed to serve as a director of the Company in part in reliance on such By-laws
and Certificate of Incorporation; and

         WHEREAS, (x) in recognition of (A) Indemnitee's need for protection
against personal liability, in order to enhance Indemnitee's service to the
Company in an effective manner, and (B) Indemnitee's reliance on the Company's
By-laws and Certificate of Incorporation, and (y) in part to provide Indemnitee
with specific contractual assurance that the protection promised by such By-laws
and Certificate of Incorporation will be available to Indemnitee (regardless of,
among other things, any amendment to or revocation of such By-laws or
Certificate of Incorporation or any change in the composition of the Board of
Directors of the Company (the "BOARD") or Change of Control (as defined in
Section 1) of the Company), the Company wishes to provide in this Agreement for
the indemnification of and the advancing of expenses to Indemnitee to the
fullest extent (whether partial or complete) permitted by law and as set forth
in this Agreement, and, to the extent insurance is maintained, for the continued
coverage of Indemnitee under the Company's directors' and officers' liability
insurance policies;

         NOW, THEREFORE, in consideration of these premises and of Indemnitee's
intention to serve the Company directly or, at the Company's request (and with
the Indemnitee's agreement), another enterprise, and, intending to be legally
bound hereby, the parties hereto agree as follows:

         1. Certain Definitions: The following terms shall have the meanings set
forth below when such terms are used in this Agreement.

         a. "BENEFICIAL OWNER" shall have the meaning given to such term in Rule
13d-3 under the Exchange Act; provided, however, that Beneficial Owner shall
exclude any Person otherwise becoming a Beneficial Owner by reason of the
shareholders of the Company approving a merger of the Company with another
entity.

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         b. "CHANGE OF CONTROL" means a change in control of the Company of a
nature that would be required to be reported in response to Item 6(e) of
Schedule 14A of Regulation 14A promulgated under the Exchange Act (as herein
defined), whether or not the Company is in fact required to comply therewith;
provided, that, without limitation, a change in control shall be deemed to have
occurred if:

         (i) any Person or group of Persons, other than (A) a trustee or other
         fiduciary holding securities under an employee benefit plan of the
         Company, or (B) a corporation owned directly or indirectly by the
         stockholders of the Company in substantially the same proportions as
         their ownership of stock of the Company is or becomes the beneficial
         owner, directly or indirectly, of securities of the Company
         representing 15% or more of the combined voting power,

         (ii) during any period of two consecutive years (not including any
         period prior to the execution of this Agreement), individuals who at
         the beginning of such period constitute the Board and any new director
         whose election by the Board or nomination for election by the Company's
         stockholders was approved by a vote of at least 2/3 of the directors
         then still in office who either were directors at the beginning of the
         period or whose election or nomination for election was previously so
         approved, cease for any reason to constitute a majority thereof,

         (iii) the effective date of a merger or consolidation of the Company
         with any other entity, other than a merger or consolidation which would
         result in the voting securities of the Company outstanding immediately
         prior to such merger or consolidation continuing to represent (either
         by remaining outstanding or by being converted into voting securities
         of the surviving entity) more than fifty-one percent (51%) of the
         combined voting power of the voting securities of the surviving entity
         outstanding immediately after such merger or consolidation and with the
         power to elect at least a majority of the board of directors or other
         governing body of such surviving entity,

         (iv) the stockholders of the Company approve or authorize a plan of
         complete liquidation of the Company or an agreement for the sale,
         lease, exchange, transfer or other disposition by the Company of (in
         one transaction or a series of transactions) all or substantially all
         the Company's assets.

         c. "EXCHANGE ACT" shall mean the Securities Exchange Act of 1934, as
amended.

         d. "EXPENSES" means all expenses, liabilities and losses (including,
without limitation, attorneys' and experts' fees and expenses, costs,
obligations, judgments, fines, interest, ERISA excise taxes, penalties or
assessments and amounts paid in settlement) incurred or suffered by Indemnitee
in connection with any Indemnifiable Event (as hereinafter defined) (including,
without limitation, in connection with, investigating, defending, being a
witness in or participating in (including on appeal), or preparing to defend, be
a witness in or participate in, any Proceeding (as hereinafter defined) relating
to any Indemnifiable Event.

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         e. "INDEPENDENT LEGAL COUNSEL" means an attorney or firm of attorneys,
selected in accordance with the provisions of Section 10, who shall not have
otherwise performed services for the Company or Indemnitee within the last five
years (other than with respect to matters concerning the rights of Indemnitee
under this Agreement, or of other Indemnitees under similar indemnity
agreements).

         f. "PERSON" shall have the meaning as set forth in Sections 13(d) and
14(d) of the Exchange Act; provided, however, that Person shall exclude (i) the
Company, (ii) any trustee or other fiduciary holding securities under an
employee benefit plan of the Company, and (iii) any corporation owned, directly
or indirectly, by the shareholders of the Company in substantially the same
proportions as their ownership of stock of the Company.

         g. "POTENTIAL CHANGE OF CONTROL" shall be deemed to have occurred if:

         (i) the Company enters into an agreement, the consummation of which
         would result in the occurrence of a Change in Control;

         (ii) any Person (as hereinabove defined), including the Company,
         publicly announces an intention to take or consider taking actions
         which if consummated would constitute a Change in Control;

         (iii) any Person (as hereinabove defined), other than the Company, any
         trustee or other fiduciary holding securities under an employee benefit
         plan of the Company or a corporation owned, directly or indirectly, by
         the stockholders of the Company in substantially the same proportions
         as their ownership of stock of the Company (A) is or becomes the
         beneficial owner, (B) discloses directly or indirectly to the Company
         or publicly a plan or intention to become the beneficial owner, or (C)
         makes a filing under the Hart-Scott-Rodino Antitrust Improvements Act
         of 1976, as amended, with respect to securities to become the
         beneficial owner, directly or indirectly, of securities representing
         9.9% or more of the combined voting power of the outstanding voting
         securities of the Company; or

         (iv) the Board adopts a resolution to the effect that, for purposes of
         this Agreement, a potential change in control of the Company has
         occurred.

         h. "PROCEEDING" means any threatened, pending or completed (x) action,
suit or proceeding, or (y) inquiry or investigation that Indemnitee in good
faith believes might lead to the institution of an action, suit or proceeding,
in each case, whether instituted by the Company or any other party and whether
civil, criminal, administrative, investigative or other.

         i. "VOTING SECURITIES" means any securities of the Company which vote
generally in the election of directors.

         2. Right to Indemnification. The Company shall indemnify and hold
harmless Indemnitee, as soon as practicable but in any event no later than
thirty days after written demand, in connection with any Proceeding to which
Indemnitee is a party or witness or in which

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Indemnitee is otherwise involved, by reason of the fact that Indemnitee is to
become, is or was a director, officer, employee, agent or fiduciary of the
Company, or is to serve or is or was serving at the request of the Company as a
director, officer, employee, agent or fiduciary of another corporation or of a
partnership, joint venture, trust or other enterprise, including, without
limitation, service with respect to an employee benefit plan, or by reason of
anything done or not done by Indemnitee in any such capacity (each such event,
occurrence or circumstance in which Indemnitee is entitled to indemnification
pursuant to this Agreement, an "INDEMNIFIABLE EVENT"), in each case to the
fullest extent permitted by applicable law, as the same exists or may hereafter
be amended (but, in the case of any such amendment, only to the extent that such
amendment permits the Company to provide broader indemnification rights than
permitted prior thereto), against all Expenses, incurred, suffered or paid by
Indemnitee in connection therewith, and such indemnification shall continue
after Indemnitee has ceased to be a director, officer, employee, agent or
fiduciary of the Company and shall inure to the benefit of Indemnitee's heirs,
executors and administrators; provided, however, that, except as provided in
Section 5 hereof with respect to Proceedings to enforce rights to
indemnification, the Company shall indemnify Indemnitee in connection with a
Proceeding (or part thereof) initiated by Indemnitee only if such Proceeding (or
part thereof) was authorized by the Board.

         3. Right to Advancement of Expenses. The right to indemnification
conferred in Section 2 hereof shall include the right to be paid by the Company
(within 2 business days of a request by Indemnitee) the Expenses incurred or
suffered by Indemnitee in connection with defending any Proceeding for which
such right to indemnification is applicable in advance of its final disposition
(an "ADVANCEMENT OF EXPENSES"); provided, however, that, if, but only if, the
Delaware General Corporation Law ("DGCL") so requires, an Advancement of
Expenses for Indemnitee in his capacity as a director or officer (and not in any
other capacity in which service was or is rendered by Indemnitee, including,
without limitation, service to an employee benefit plan) shall be made only upon
delivery to the Company of an undertaking (an "UNDERTAKING"), by or on behalf of
Indemnitee, to repay all amounts so advanced if it shall ultimately be
determined by final judicial decision from which there is no further right to
appeal (a "FINAL ADJUDICATION") that Indemnitee is not entitled to be
indemnified for such Expenses under this Agreement or otherwise.

         4. Partial Indemnity, Etc. If Indemnitee is entitled under any
provision of this Agreement to indemnification by the Company for some or a
portion of any Expenses incurred or suffered by Indemnitee in connection with
any Proceeding but not, however, for all of the total amount thereof, the
Company shall nevertheless indemnify Indemnitee for the portion thereof to which
Indemnitee is entitled. Moreover, notwithstanding any other provision of this
Agreement, to the extent that Indemnitee has been successful on the merits or
otherwise in defense of any or all Proceedings relating in whole or in part to
an Indemnifiable Event or in defense of any issue or matter therein, including
dismissal without prejudice, Indemnitee shall be indemnified against all
Expenses incurred in connection therewith.

         5. Right of Indemnitee to Bring Suit.

         (a) If a claim under Section 2, 3 or 4 of this Agreement is not paid in
full by the Company within thirty days after a written claim has been received
by the Company, except in the case of a

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claim for an Advancement of Expenses, in which case the applicable period shall
be two days after a written request has been received by the Company, Indemnitee
may at any time thereafter bring suit against the Company to recover the unpaid
amount of such claim.

         (b) The Company shall indemnify and hold harmless Indemnitee from and
against any and all Expenses and, if requested by Indemnitee, shall (within two
business days of any such request) advance funds to Indemnitee to cover such
Expenses, which are incurred by Indemnitee in connection with any action brought
by Indemnitee for (i) indemnification or advance payment of Expenses by the
Company under this Agreement or any other agreement or Company By-law now or
hereafter in effect relating to Indemnifiable Events and/or (ii) recovery under
any directors' and officers' liability insurance policies maintained by the
Company, regardless of whether Indemnitee ultimately is determined to be
entitled to such indemnification, advance expense payment or insurance recovery,
as the case may be.

         (c) (i) In any suit brought by Indemnitee to enforce a right to
indemnification hereunder (but not in a suit brought by Indemnitee to enforce a
right to an Advancement of Expenses) it shall be a defense that, and (ii) in any
suit brought by the Company to recover an Advancement of Expenses pursuant to
the terms of an Undertaking the Company shall be entitled to recover such
Expenses upon a Final Adjudication that, Indemnitee has not met any applicable
standard for indemnification required to be met pursuant to the DGCL. Neither
the failure of the Company (including its directors, Independent Legal Counsel,
or its stockholders) to have made a determination prior to the commencement of
such suit that indemnification of Indemnitee is proper in the circumstances
because Indemnitee has met the applicable standard of conduct set forth in the
DGCL, nor an actual determination by the Company (including its directors,
Independent Legal Counsel, or its stockholders) that Indemnitee has not met such
applicable standard of conduct, shall create a presumption that Indemnitee has
not met the applicable standard of conduct or, in the case of such a suit
brought by Indemnitee, be a defense to such suit.

         (d) In any suit brought by Indemnitee to enforce a right to
indemnification or to an Advancement of Expenses hereunder, or by the Company to
recover an Advancement of Expenses pursuant to the terms of an Undertaking, the
burden of proving that Indemnitee is not entitled to be indemnified, or to such
Advancement of Expenses, under this Agreement or otherwise, shall be on the
Company.

         6. Settlement. The Company shall have no obligation to indemnify
Indemnitee under this Agreement for any amounts paid in settlement of any
Proceeding effected without the Company's prior written consent. The Company
shall not settle any Proceeding in any manner that would impose any fine or any
obligation on Indemnitee without Indemnitee's prior written consent and no
settlement of any Proceeding shall be entered into unless, if applicable, in
Indemnitee's discretion, such settlement includes, as an unconditional term
thereof, the delivery by the claimant or plaintiff in such Proceeding to
Indemnitee of a duly executed written release of Indemnitee from all liability
or obligation in respect of such Proceeding, which release shall be reasonably
satisfactory in form and substance to Indemnitee and Indemnitee's counsel. The
Company shall not unreasonably withhold its consent to any proposed settlement.

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<PAGE>

         7. Rights Not Exclusive. The rights provided under this Agreement shall
not be deemed exclusive of any other rights to which Indemnitee may be entitled
under the Company's By-Laws, the Company's Certificate of Incorporation, the
DGCL, any agreement, any vote of stockholders or of disinterested directors or
otherwise, both as to action in his official capacity and as to action in any
other capacity, and shall continue after Indemnitee ceases to serve the Company
as a director, officer, employee, agent or fiduciary (or person named as a
prospective director) of the Company. To the extent that a change in the DGCL
(whether by statute or judicial decision) permits greater indemnification by
agreement than would be afforded currently under the Company's By-laws, the
Company's Certificate of Incorporation and this Agreement, it is the intent of
the parties hereto that Indemnitee shall enjoy by this Agreement the greater
benefits so afforded by such change. Unless otherwise required by law, the
Company shall not adopt any amendment to its By-laws or Certificate of
Incorporation the effect of which would be to deny, diminish or encumber the
Indemnitee's rights to indemnification pursuant to this Agreement, the Company's
Certificate of Incorporation, the Company's By-laws, the DGCL or any other
applicable law as applied to any act or failure to act occurring in whole or in
part.

         8. Severability. The provisions of this Agreement shall be severable in
the event that any of the provisions hereof (including any provision within a
single section, paragraph or sentence) are held by a court of competent
jurisdiction to be invalid, void or otherwise unenforceable in any respect, and
the validity and enforceability of any such provision in every other respect and
of the remaining provisions hereof shall not be in any way impaired and shall
remain enforceable to the fullest extent permitted by law.

         9. Choice of Law. This Agreement shall be governed by and construed and
enforced in accordance with the laws of the State of Delaware, without giving
effect to any conflict of laws provisions or principles.

         10. Change of Control. The Company agrees that if there is a Change of
Control of the Company, then with respect to all matters thereafter arising
concerning the rights of Indemnitee to indemnity payments and Advancement of
Expenses under this Agreement or any other agreement or Company By-law now or
hereafter in effect relating to Indemnifiable Events, the Company shall seek
legal advice only from Independent Legal Counsel selected by Indemnitee and
approved by the Company (which approval shall not be unreasonably withheld).
Such counsel, among other things, shall render its written opinion to the
Company and Indemnitee as to whether and to what extent the Indemnitee would be
permitted to be indemnified under applicable law. The Company agrees to pay the
reasonable fees of the Independent Legal Counsel referred to above and to
indemnify fully such counsel against any and all expenses (including attorneys'
fees), claims, liabilities and damages arising out of or relating to this
Agreement or its engagement pursuant hereto.

         11. Establishment of Trust. In the event of a Potential Change in
Control, the Company may create a trust for the benefit of the Indemnitee
(either alone or together with one or more other indemnitees) and from time to
time fund such trust in such amounts as the Board may determine to satisfy
Expenses reasonably anticipated to be incurred in connection with investigating,
preparing for and defending any claim relating to an Indemnifiable Event, and
all judgments, fines, penalties and settlement amounts of all claims relating to
an Indemnifiable

                                       -6
<PAGE>

Event from time to time paid or claimed, reasonably anticipated or proposed to
be paid. The terms of any trust established pursuant hereto shall provide that
upon a Change in Control (i) the trust shall not be revoked or the principal
thereof invaded, without the written consent of the Indemnitee, (ii) the trustee
shall advance, within ten business days of a request by the Indemnitee, all
Expenses to the Indemnitee, (iii) the trustee shall promptly pay to the
Indemnitee all amounts for which the Indemnitee shall be entitled to
indemnification pursuant to this Agreement or otherwise, and (iv) all unexpended
funds in such trust shall revert to the Company upon a final determination by a
court of competent jurisdiction, as the case may be, that the Indemnitee has
been fully indemnified under the terms of this Agreement. The trustee shall be a
person or entity satisfactory to the Indemnitee. Nothing in this Section 11
shall relieve the Company of any of its obligations under this Agreement.

         12. Burden of Proof. In connection with any determination as to whether
Indemnitee is entitled to be indemnified hereunder the burden of proof shall be
on the Company to establish that Indemnitee is not so entitled.

         13. No Presumptions. For purposes of this Agreement, the termination of
any Proceeding, by judgment, order, settlement (whether with or without court
approval) or conviction, or upon a plea of nolo contendere, or its equivalent,
shall not create a presumption that Indemnitee did not meet any particular
standard of conduct or have any particular belief or that a court has determined
that indemnification is not permitted by applicable law.

         14. Liability Insurance. The Company is maintaining (pursuant to a
policy or policies, true and complete copies of which have been made available
to Indemnitee), and shall maintain, an insurance policy or policies providing
directors' and officers' liability insurance. Indemnitee shall be covered by
such policy or policies, for proposing to become, serving as or having served as
a director, officer, employee, agent or fiduciary (or person named as a
prospective director) of the Company, or, at the request of the Company, of
another corporation or of a partnership, joint venture, trust or other
enterprise, to the maximum extent of the coverage available for any person in
such capacity. The Company shall maintain the Company's insurance policy
providing directors' and officers' liability insurance that is in place as of
the date hereof for a period from the date hereof until six years after the last
date on which Indemnitee ceases to be a director, officer, employee, consultant,
agent or fiduciary of the Company (or person named as a prospective director)
or, at the request of the Company, of another corporation, partnership, joint
venture, employee benefit plan, trust or other enterprise; provided, however,
that the Company may substitute therefor policies of substantially similar
coverage and amounts containing material terms no less advantageous to the
Indemnitee.

         15. Subrogation. In the event of any payment under this Agreement, the
Company shall be subrogated to the extent of such payment to all of the rights
of recovery of Indemnitee, who shall execute all papers required and take all
action necessary to secure such rights, including execution of such documents as
are necessary to enable the Company to bring suit to enforce such rights.

         16. Period of Limitations. No legal action shall be brought and no
cause of action shall be asserted by or in the right of the Company against
Indemnitee, Indemnitee's spouse, heirs,

                                       -7
<PAGE>

executors or personal or legal representatives after the expiration of two years
from the date of accrual of such cause of action, and any claim or cause of
action of the Company shall be extinguished and deemed released unless asserted
by the timely filing of a legal action within such two-year period; provided,
however, that if any shorter period of limitations is otherwise applicable to
any such cause of action such shorter period shall govern.

         17. Successor and Assigns; Effectiveness of Agreement. This Agreement
shall be (i) binding upon all successors and assigns of the Company (including
any transferee of all or substantially all of its assets and any successor by
merger or otherwise by operation of law) and (ii) shall be binding on and inure
to the benefit of the heirs, personal representatives and estate of Indemnitee.
This Agreement shall continue in effect regardless of whether Indemnitee becomes
a director, officer, employee, agent or fiduciary (or person named as a
prospective director) of the Company, or continues to serve as a director,
officer, employee, agent or fiduciary (or person named as a prospective
director) of the Company or of any other corporation, partnership, joint
venture, trust or other enterprise at the request of the Company.

         18. Amendment. No amendment, modification, termination or cancellation
of this Agreement shall be effective unless made in a writing signed by each of
the parties hereto.

         19. Notices. All notices, requests, demands and other communications
under this Agreement shall be in writing and shall be deemed to have been duly
given (a) if delivered by hand and receipted for by the party to whom said
notice or other communication shall have been directed, or (b) mailed by
certified or registered mail with postage prepaid, on the third business day
after the date on which it is so mailed:

         (a) If to Indemnitee to:

             ------------------------------
             ------------------------------
             ------------------------------

or such other address as Indemnitee shall provide to the Company.

         (b) If to the Company to:

             eXegenics Inc.
             2110 Research Row
             Dallas, Texas 75235
             Attn:
                   ------------------------

or such other address as may have been furnished to Indemnitee by the Company.

               [Remainder of this page intentionally left blank.]

                                       -8
<PAGE>

         IN WITNESS WHEREOF, the Company and Indemnitee have executed this
Agreement as of the day and year first above written.

                                           EXEGENICS INC.

                                           By:
                                               --------------------------------

                                           Name:
                                                 ------------------------------

                                           Title:
                                                  -----------------------------

                                           INDEMNITEE

                                           ------------------------------------

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