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penn_biontechxamd2xfully

UNIVERSITY OF PENNSYLVANIA  AMENDMENT NO. 2 TO COLLABORATION & LICENSE AGREEMENT  This Amendment No.2 to the Collaboration & License Agreement (“Amendment No. 2 ”) by and  between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation (“Penn”),  with offices located at Penn Center for Innovation, 3600 Civic Center Blvd, 9th Floor, Philadelphia, PA  19104-4310, and BioNTech SE, a German corporation (“Licensee”), having a place of business at An der  Goldgrube 12, 55131 Mainz, Germany is effective December 22, 2021 (“Amendment No. 2 Effective  Date”).  Penn and Licensee may be referred to herein as a “Party” or, collectively, as “Parties”.  RECITALS:  WHEREAS, the Parties entered into a Collaboration & License Agreement dated October 9, 2018,  as previously amended on September 8, 2021, (“Agreement”) under which the Parties are undertaking the  development, manufacture and commercialization of mRNA vaccines for infectious diseases, including  RNA synthesis, formulation and GMP manufacturing. Capitalized terms used but not defined herein shall  have the meanings ascribed to them in the Agreement;   WHEREAS, on January 4, 2021, BioNTech RNA Pharmaceuticals GmbH transferred all its assets  to BioNTech SE with economic effect as of January 1, 2021, including the Agreement.  WHEREAS, the Parties are in active negotiation of a separate collaboration and license agreement  (“Expanded Alliance Agreement”) to, amongst other contemplated research and development programs,  develop products based on certain additional Penn background patent rights (“Additional Penn  Background Patents”)  WHEREAS, Parties are now entering into this Amendment No. 2 because the Parties want to begin  developing products based on the Additional Penn Background Patents commencing on the Amendment  No. 2 Effective Date, while the Parties work diligently to complete their negotiation of the Expanded  Alliance Agreement between the Parties;      WHEREAS, the Parties now desire to amend the Agreement as set forth herein.  NOW, THEREFORE, in consideration of the various promises and undertakings set forth herein,  the Parties agree as follows:  1. Term of this Amendment No. 2. This Amendment No. 2 shall become effective on the Amendment No. 2 Effective Date and terminate upon the earlier of 1) six (6) months from the Amendment No. 2 Effective Date or 2) the effective date of the Expanded Alliance Agreement (“Amendment No. 2 Term”).  Upon mutual agreement by the Parties, the Amendment No. 2 Term may be extended.  At the end of the Amendment No. 2 Term, the Parties shall amend the Agreement to remove the Targeting Research Plan. 2. Scope of work.  The Research Program detailed in Exhibit C to the Agreement (“Original Research Program”) is hereby amended to include the additional research plans in Schedule A-1 hereto (“Targeting Research Plan”) only during the Amendment No. 2 Term.  Execution of this Amendment No. 2 does not obligate the Parties to enter into the Expanded Alliance Agreement.  If the Amendment No. 2 Term ends upon the effective date of the Expanded Alliance Agreement, the Parties shall determine by mutual agreement if the Targeting Research Plan shall be moved to and included as a portion of the research program under the Expanded Alliance Agreement. THE SYMBOL “[***]” DENOTES PLACES WHERE CERTAIN IDENTIFIED INFORMATION HAS BEEN  EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (i) NOT MATERIAL, AND (ii) WOULD LIKELY CAUSE  COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED Exhibit 4.63 

 

Page 2  3. Funding of the Research Program. During the Amendment No. 2 Term, up to ($[***]) of the existing funding for the Original Research Program under the Agreement can be reallocated to fund the Targeting Research Plan upon mutual agreement of the Parties (“Targeting Research Plan Funding”).  Penn represents that the Targeting Research Plan Funding shall not detrimentally impact any existing rights of Licensee under the Agreement.  Any portion of the Targeting Research Plan Funding not used under this Amendment No. 2 shall be reallocated to the Original Research Program following termination of this Amendment No. 2.  No further funding or payment by Licensee shall be required in connection with this Amendment No. 2, and the used portion of the Targeting Research Plan Funding will not be replenished by Licensee for the Original Research Program at the conclusion of the Amendment No. 2 Term. 4. Additional Penn Background Patents. The Additional Penn Background Patents means Penn’s rights and interest in the patents and patent applications specifically listed in Schedule B-1 hereto, together with any unlisted patents and patent applications claiming priority thereto, and any continuations, continuations-in-part (to the extent related directly to the subject matter of the parent application or containing new information developed pursuant to the Research Program), reissues, reexamination certificates, substitutions, divisionals, supplementary protection certificates, renewals, registrations, extensions including all confirmations, revalidations, patents of addition, PCTs, and pediatric exclusivity periods and all foreign counterparts thereof, and any patents issued or issuing with respect to any of the foregoing. 5. Option to Additional Penn Background Patents. Penn hereby grants to Licensee a time-limited option during the Amendment No.2 Term and pursuant to or superseded by the terms of the Expanded Alliance Agreement to negotiate to acquire a commercial license to  Additional Penn Background Patents Controlled by Penn to research, develop, make, have made, use, import, offer for sale, commercialize and sell products using or incorporating Additional Penn Background Patents  in the APBP Field of Use (the “APBP Option”). For clarity, the APBP Option can only be exercised pursuant to the terms of and under the Expanded Alliance Agreement and shall automatically expire at the end of the Amendment No.2 Term.  “APBP Field of Use” means a) mRNA based diagnostics and therapeutics including mRNA based CAR-T and TCR therapies and b) lipid nanoparticle based mRNA delivery technologies, each for the diagnosis, detection, evaluation, prophylaxis and treatment of diseases in humans and animals, but specifically excluding the treatment and/or prevention of fibrosis in humans, including fibrosis caused by autoimmune disease and/or inflammation.  “Controlled” means, with respect to intellectual property rights, that a Party or one of its Affiliates owns or has a license or sublicense to such intellectual property rights and has the ability to provide to, grant a license or sublicense to, or assign its right, title and interest in and to, such intellectual property rights as provided for in this Agreement without violating the terms of any agreement or other arrangement with any Third Party. 6. Prosecution and Maintenance of Additional Penn Background Patents. Additional Penn Background Patents will be held in the name of Penn. During the Amendment No.2 Term, Penn shall have the sole and exclusive right to control the preparation, filing, prosecution and maintenance of the Additional Penn Background Patents.  Patent expense reimbursement by Licensee for the APBP Option to the Additional Penn Background Patents shall be addressed in the Expanded Alliance Agreement. 7. Entire Agreement of the Parties; Amendments.  The Agreement, including any Exhibits, as amended by this Amendment No. 2, constitutes and contains the entire understanding and agreement of the Parties with respect to the subject matter hereof and cancel and supersedes any and all prior negotiations, correspondence, understandings and agreements between the Parties, whether oral or written, regarding such subject matter.  No waiver, modification or amendment of 

 

Page 3  any provision of the Agreement as amended and/or this Amendment No. 2 shall be valid or effective  unless made in a writing referencing the Agreement and/or this Amendment No. 2 and signed by a  duly authorized officer of each Party.   8. Conflict. Other than as set forth in this Amendment No.2, all the terms and conditions of the Agreement shall continue in full force and effect.  In the event of a conflict between the Agreement and the Amendment No.2, the Amendment No.2 shall control. 9. Counterparts.  This Amendment No. 2 may be executed in counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the same instrument. A portable document format (PDF) or electronic copy of this Amendment No. 2, including the signature pages, will be deemed an original. [SIGNATURE PAGE FOLLOWS]  

 

UNIVERSITY OF PENNSYLVANIA IN WITNESS WHEREOF, the duly authorized representatives of the Parties hereby execute this  Amendment No. 2 as of the date first written above. THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA By:  BIONTECH SE By:  Name: Sean Marret Title: Managing Director By:  Name: Jens Holstein Title: Managing Director Name: John S. Swartley, Ph.D. Title: Associate Vice Provost for Research and  Managing Director, Penn Center for Innovation I have read and understood the responsibilities  of the Designated Penn Contact:  By: . Drew Weissman Name: Dr. Drew Weissman 

 

Page 2  Schedule A-1  Additional Research Plans  [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] 

 

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Page 5  Schedule B-1  Additional Penn Background Patents  [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***] [***]pharmaserv_marburgxm536-

Lease Agreement  for  Areas and Rooms in Building M536 and Building M537  at the Behringwerke site in Marburg  between  Pharmaserv GmbH  Emil-von-Behring-Straße 76, 35041 Marburg, Germany  - hereinafter referred to as the “Lessor” - and  BioNTech Manufacturing Marburg GmbH  Emil-von-Behring-Straße 76, 35041 Marburg, Germany  - hereinafter referred to as the “Lessee” - Lessor and Lessee individually also referred to as the “Party”  or jointly as the “Parties”  Page 1 of 32  THE SYMBOL “[***]” DENOTES PLACES WHERE CERTAIN IDENTIFIED INFORMATION HAS BEEN  EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (i) NOT MATERIAL, AND (ii) WOULD LIKELY CAUSE  COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED Exhibit 4.64 

 

Preliminary remarks    The Lessee entered into the Lease Agreement for Buildings M537 and M536 (originally  concluded between Pharmaserv GmbH & Co. KG and Chiron Behring GmbH & Co. KG) by  way of a Takeover Agreement on July 1, 2021, 12:00 a.m. This Lease Agreement shall  hereinafter be referred to as the “Old Agreement” and existed between Pharmaserv GmbH  as the Lessor and GSK Vaccines GmbH as the Lessee before the takeover by the Lessee.  The Old Agreement automatically ends on November 30, 2021, 12:00 a.m. the following  day, according to the Takeover Agreement. The Parties have therefore agreed to reorganize  the tenancy from December 1, 2021, 12:00 a.m., under this Lease Agreement.  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]                    Page 2 of 32     

 

[***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  Taking into account and continuing the aforementioned premises, the Parties agree as  follows:    § 1  Leased Property    (1) The Lessor, as owner, rents to the Lessee the areas and rooms marked in green in  Appendix 1) within building M536 and building M537 at the location Behringwerke, Emil- von-Behring-Straße 76, 35041 Marburg, including the circulation and ancillary areas, insofar  as these circulation and ancillary areas are marked “green” instead of “gray” in Appendix 1)  (hereinafter referred to as the “Leased Property”).  The technical areas marked in blue may be used by the Lessee free of charge for the  installation of the Lessee’s own technical equipment, depending on the space available.  The outer roof areas and facade areas and the outer parts of the building are not part of the  lease. The Lessee is entitled to use these roof and                     Page 3 of 32  

 

facade areas free of charge in agreement with the Lessor, only to the extent that they are  required for the realization of the purpose of the lease pursuant to § 2 of this Agreement.  The other parts of the building structure (for example, non-load-bearing walls), fixtures,  fittings and equipment (also referred to in this Agreement as “Finishes”) located in building  M536 and building M537 are leased to the Lessee and part of the Leased Property only to  the extent that they are listed in Appendix 1) or listed as parts of the Leased Property in  Appendix 2.1).  If and to the extent that internal parts of the building structure (for example walls), fixtures,  fittings and equipment are present on the leased areas/rooms, the leased ancillary areas or  circulation areas but are not listed in Appendix 1) or listed in Appendix 2.1), they are not  part of the Leased Property, are therefore not owed by the Lessor and are only inserted into  the buildings M537 and M536 for a temporary purpose (§95 of the German Civil Code  [BGB]). These parts of the internal building structure, fixtures, fittings and equipment have  been taken over by the Lessee from the previous tenants. Insofar as no takeover by the  Lessee has taken place (for example, because it was not taken into account in  corresponding transfer agreements among the previous tenants or with the Lessee or  because it was ineffectively transferred), the right to use these parts of the internal building  structure, fixtures, fittings and equipment is nevertheless not the subject of this Lease  Agreement and is solely a matter between the Lessee and the previous tenants.  In particular, the lease does not include the Finishes that serve pharmaceutical purposes in  the Leased Property which have been carried out in the Leased Property by the Lessee  and the previous tenants, in particular by GSK Vaccines GmbH.  (2) In addition to Appendix 2.1), the condition of the Leased Property owed by the Lessor  shall also result from Appendix 2.2) (building description of the Leased Property,  equipment description of the Leased Property). The condition of the Leased Property set  forth in Appendices 1), 2.1) and 2.2) shall merely constitute a description of the Leased  Property and not a warranted characteristic.  The Lessee has possessed and used the Leased Property without interruption since July 1,  2021. The Lessee has not reported any defects.                        Page 4 of 32  

 

(3) The following special features are agreed upon with regard to the drainage pipe and  wastewater system: drainage pipe (this is the wastewater pipe beginning at the inlet of the  floor slab up to the first connection manhole in front of the building) including stormwater  pipes (these are the pipes carrying the stormwater away from the roof up to the first  connection manhole in front of the building) shall be made available for use, repaired and  maintained, serviced and, if necessary, renewed by the Lessor for the duration of the lease  in proper and functional condition in accordance with the following provisions, regardless of  whether they are part of the Leased Property:  The drainage pipe extending from the floor slab/floor inlet (as shown in the section attached  to Appendix 9) marked in red) to the connection to the wastewater disposal system of the  Behringwerke Industrial Park shall be refurbished immediately and as soon as possible after  the commencement of the lease at the expense of the Lessor in accordance with the  refurbishment concept – Appendix 9) – even if this drainage pipe is not part of the Leased  Property.  In addition, the wastewater pipes located in the building shall be refurbished by the Lessor  at the Lessor’s expense without delay and as soon as possible after the commencement of  the lease in accordance with Appendix 9) insofar as they are part of the Leased Property  (see Appendix 9)), whereby the wastewater pipes not required by the Lessee shall first be  jointly identified, documented by addendum to this Lease Agreement and subsequently  professionally plugged. After these pipes have been plugged, they are no longer part of the  Leased Property. Claims for damages on the part of the Lessor due to possible damage to  the drainage pipe and the stormwater pipes by the Lessee after the commencement of the  lease shall remain unaffected by the assignment of duties to the Lessor made in  accordance with § 1(3)(1).  (4) The Lessor shall be entitled to have existing technical building equipment in the Leased  Property, insofar as it is part of the Leased Property, in particular fire protection and fault  alarm systems, including the infrastructure required for it, to install it, convert and extend it,  expand it and operate it and to renew it.                                          Page 5 of 32  

 

§ 2  Purpose of the lease, orders, requirements, permits    (1) The Lessor shall provide the Leased Property to the Lessee for the purpose of carrying out  pharmaceutical production, together with production-specific ancillary activities, within it with  the inclusion of preexisting finishes, fixtures and equipment of the previous tenants and  finishes to be carried out by the Lessee itself. The Lessor shall consent to any changes to  the Leased Property itself that accompany the finishes made to the Leased Property  unless good cause stands in the way of the Lessor’s consent. Good cause in the sense of  this provision includes, in particular, effects of the planned changes on statics, fire  protection, development, roof or facade of the Leased Property, additional costs threatening  the Lessor as a result of the changes, or if the changes are opposed by provisions under  public law.  Other uses, in particular the storage, handling or other transfer to the Leased Property of  hazardous materials, explosives, foodstuffs, other perishable goods or objects from which a  hazard may emanate or the storage, handling or other transfer of which require special  structural conditions or equipment of the Leased Property or building which are not  described in Appendices 2.1) and 2.2) or which are opposed by provisions of public law,  are not included in the purpose of the lease.  If a special use within the agreed purpose of the lease requires special equipment (e.g. floor  coverings or air-conditioning equipment) of the Leased Property that goes beyond the  building and equipment descriptions pursuant to Appendices 2.1) and 2.2), it shall be the  responsibility of the Lessee to provide such equipment at its own expense and to obtain the  relevant permits. This shall apply accordingly in the event that changes are made to the  Leased Property in the course of any finishes. In all other respects, § 11 (6) of this Lease  Agreement shall apply.  (2) Official orders and requirements as well as necessary permits that are based exclusively on  or required due to the general condition and/or location of the Leased Property shall be  fulfilled or obtained by the Lessor at its own expense for the entire duration                        Page 6 of 32  

 

  of the lease.  Insofar as official requirements and/or the obtaining/maintenance of official permits are  caused by the personal or special operational circumstances of the Lessee or in the special  circumstances of its business operations, the measures and costs associated therewith shall  be the sole responsibility of the Lessee.  In this respect, the Lessee shall also comply with any official orders and requirements  relating to the use of the Leased Property issued during the term of the lease at its own  expense, even if they are directed against the Lessee. The Lessor shall provide the Lessee  with the necessary and reasonable support in this regard.  (3) A change of the purpose of use pursuant to subsection (1) above as well as changes of use  of any kind requiring an official permit shall require the prior written consent of the Lessor.  The Lessee shall have no claim to such consent. Any declarations of consent by the Lessor  shall always, even if this is not repeated in the declaration of consent, be subject to any  required official permit, the procurement of which shall be the responsibility of the Lessee at  its own expense. Prior to the implementation of the approved changes the Lessee shall  demonstrate to the Lessor that either the official permit required for this purpose has been  granted in a legally valid manner or that such a permit is not required, and shall  comprehensively explain any disruptive impacts of the intended changed use.    (4) Insofar as official permits required for the use intended by the Lessee are not granted or are  not granted to a sufficient extent, this shall not entitle the Lessee to terminate this lease,  unless the cause thereof is a deviation of the actual condition of the Leased Property from  the agreed condition of the Leased Property.                                Page 7 of 32  

 

§ 3  Regulations on value added tax    (1) In accordance with § 9 of the German Value Added Tax Act, the Lessor has waived the VAT  exemption pursuant to § 4 (12) (a) of the German Value Added Tax Act (“UStG”) for the  rental of the Leased Property (VAT option). As a result, the Lessee shall pay VAT in the  respective statutory amount in addition to the rent, operating costs and advance payments  for operating costs.  The Lessee is aware that the Lessor’s VAT option is only permissible under the conditions  set out in § 9 (2) UStG.  Wording of § 9 (2) UStG for informational purposes:  “The waiver of tax exemption under subsection (1) is permissible in the case of the  creation and transfer of heritable building rights (§ 4 (9) (a)), the renting or leasing of  real estate (§ 4 (12) (1) (a)) and the transactions referred to in § 4 (12) (1) (b) and (c)  only insofar as the recipient of the service uses or intends to use the real estate  exclusively for transactions that do not exclude the deduction of input tax. The  entrepreneur must provide evidence of these conditions.”  In view of this, the Parties enter into the following agreements:  (2) The Lessee agrees to use the Leased Property exclusively for transactions which do not  exclude the deduction of input tax by the Lessor.    (3) Furthermore, the Lessee agrees to provide the Lessor at any time, upon request and  without delay, with the documents required to enable the Lessor to comply with its  obligations to provide evidence to the tax authorities pursuant to § 9 (2) UStG. In this  respect, the Lessor may only require the Lessee to submit those documents and/or  declarations that are required of it by the responsible tax authorities. The Lessee shall be  entitled to forward the requested documents directly to the tax authorities.    (4) Should circumstances arise on the part of the Lessee or a subtenant, or be assumed by the  tax authorities in the course of an external tax audit,                          Page 8 of 32   

 

which affect the permissibility of the Lessor’s VAT option, the Lessee shall be obliged to  inform the Lessor thereof in written form without delay.    (5) In the event of a sublease, the Lessee shall be obligated to opt for VAT for the sublease and  otherwise to impose the obligations under § 3 (2) to (5) of this Lease Agreement on the  subtenant in the sublease agreement in such a way that the Lessor may also derive rights  directly against the subtenant under the agreement of the Lessee with the subtenant  (agreement in favor of third parties, § 328 of the German Civil Code [BGB]). The Lessee  shall be liable to the Lessor for ensuring that the subtenant complies with these obligations.    (6) Insofar and as long as the tax authorities apply a de minimis limitation with no detrimental  effect – also recognized by the tax courts – with regard to the term “exclusive” use for  transactions which do not exclude the deduction of input tax, this de minimis limit shall at the  same time limit the exclusivity referred to in the above provisions.    (7) Should the Lessee and/or, in the event of a sublease, the subtenant violate the obligations  under § 3 (2) to (6) of this Lease Agreement, the Lessee shall compensate the Lessor for  all damages and other disadvantages caused thereby.    (8) If the precondition for the Lessor’s VAT option under § 3 (1) of this Lease Agreement no  longer applies because the Lessee does not use the Leased Property in accordance with  the agreement made in § 3 (2) of this Lease Agreement, the Lessor shall no longer be  obliged to list VAT separately. In this case, the net base rent owed under this Lease  Agreement – without prejudice to any further rights and/or claims of the Lessor – shall be  increased as of the date on which the precondition for the VAT option ceased to apply by the  amount corresponding to the VAT that would have been payable by the Lessee if the  precondition for the VAT option had not ceased to apply. If the Lessor only becomes aware  of the absence of the precondition for the VAT option after the fact, the Lessor shall be  entitled to correct the invoices issued to date in such a way that the invoiced rent with VAT  shown corresponds to the contractually owed rent without VAT shown. Further claims                           Page 9 of 32   

 

of the Lessor based on a breach of contract by the Lessee shall remain unaffected.    (9) Claims of the Lessor against the Lessee under § 3 shall become time-barred upon  expiration of ten years after termination of the lease. Should the Lessee or the subtenant fail  to comply with its duty to provide information pursuant to § 3 (4), the limitation period shall  be extended to 15 years for all claims based on circumstances of which the Lessor has not  been informed by the Lessee or subtenant in breach of its duty.  § 4  Lease term    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]    (3) Tacit extension of the lease pursuant to § 545 BGB is excluded.                          Page 10 of 32   

 

§ 5  Uninterrupted possession of the Leased Property, keys    (1) The Lessee is already in possession of the Leased Property. The Parties confirm that the  Lessee’s possession will be maintained uninterrupted.    (2) The Lessee is also in possession of the necessary keys. With the consent of the Lessor, it  is entitled to produce additional keys at its own expense.  All keys shall be handed over by the Lessee to the Lessor after the end of the lease.  The Lessee is entitled, in consultation with the Lessor, to install and operate its own locking  system for its leased areas at its own expense or to change and expand an existing locking  system. The Lessee shall provide the Lessor with access to the leased areas and rooms for  the cases agreed in this Lease Agreement. When moving out, the Lessee must restore the  Lessor’s locking system to its original condition where possible or provide the changed or  extended locking system to the Lessor, whereby the Lessee shall not be entitled to  compensation in this case.    § 6  Rent    (1) The monthly net base rent (graduated rent) also for the option periods is fixed in Appendix 4)  by the Parties and is the result of extensive negotiations between the Lessor and Lessee. A  significant reduction in rent was included in these negotiations, as well as the now agreed  definition of the Leased Property and the corresponding allocation of maintenance and  repair obligations.    (2) With regard to the net base rent and with regard to all operating costs pursuant to § 8, the  Lessee shall also pay VAT at the respective statutory rate, i.e. currently 19%.                      Page 11 of 32   

 

(3) The monthly rent, including the advance payment of operating costs pursuant to § 8, shall be  paid to the Lessor in advance, free of charge, no later than on the [***] working day of each  month to the account at Volksbank Mittelhessen eG. [***] with the reference [***].    (4) The Lessee shall only be entitled to set off against payment claims of the Lessor and to  exercise a right of retention if its counterclaims are acknowledged or have become  established by a final judgment.    § 7  Rent adjustment    The monthly net base rent shall increase on January 1 of each year by [***] compared to the  previous year. This annual increase is already taken into account in the statement of rent in  Appendix 4 of the Lease Agreement.    § 8  Operating costs    (1) The Lessee shall bear all operating costs in addition to the net base rent. Operating costs  are the costs incurred by the Lessor on an ongoing basis as a result of ownership of the  property or as a result of the intended use of the Leased Property, the building or the  management unit, its facilities and equipment and the land. The operating costs to be borne  by the Lessee currently include those pursuant to Appendix 5.1) to this Lease Agreement.  The operating costs to be borne by the Lessee also include the operating costs incurred by  the Lessor on an ongoing basis as a result of the operation of the Behringwerke site and  referred to as “Basic Infrastructure Costs” in Appendix 5.1).    (2) If public assessments are newly introduced or if new operating costs within the meaning of  this Lease Agreement are incurred by the Lessor as a result of the fulfillment of statutory  obligations with respect to the Leased Property that have arisen after the conclusion of this  Lease Agreement, such costs may be apportioned in accordance with this Lease  Agreement, and the advance payment of operating costs may be adjusted accordingly. The  adjustment of operating costs specified in Appendix 5.1) as well as the establishment of  new operating costs                 Page 12 of 32  which do not relate to public assessments or the fulfillment of statutory obligations arising  after the conclusion of the Lease Agreement with respect to the Leased Property may only  

 

be made taking into account the principle of sound financial management. The Lessor shall  inform the Lessee of the operating costs without delay.    (3) Insofar as the Lessor provides services in its own business operations which, in the case of  their provision by third parties would have to be borne as part of the operating costs in  accordance with this Lease Agreement, the Lessor may charge for such services at an  amount which corresponds to appropriate remuneration plus, if applicable, the VAT in force  at the time of performance for these services (e.g., if agreed, supply of energy and media to  the location at the respective prices, elevator maintenance).    (4) Unless mandatory provisions to the contrary apply, the operating costs shall be apportioned  in accordance with the share of the total area of the building attributable to the Lessee. The  settlement period shall be the calendar year. The ratio between the Lessee’s share of the  area and the total area of Building M536 and Building M537 agreed only for the purpose of  allocating the operating costs is bindingly agreed by the Parties in Appendix 3) to this  Lease Agreement.    (5) The Lessor may change the apportionment scale with future effect in agreement with the  Lessee at its reasonable discretion.    (6) The operating costs referred to as “Basic Infrastructure Costs” in Appendix 5.1) shall be  determined in accordance with the agreement made in Appendix 5.1) for the settlement  year and shall be apportioned to the Lessee in accordance with the procedures agreed in  Appendix 5.1). The Basic Infrastructure Costs shall not be subject to the monthly advance  payment of operating costs (Appendix 5.2)), but shall be invoiced separately by the Lessor  and reimbursed by the Lessee.    (7) Insofar as fire protection and fault alarm systems and other technical building equipment  required for the operation of the building – with the exception of access control equipment –  is located in areas shared with other tenants of Building M536                      Page 13 of 32     

 

and/or Building M537 and/or other buildings, these buildings shall form the settlement unit  for these types of costs. The tenants shall bear the costs of these facilities in proportion to  the areas used exclusively by each of them to the total area of the settlement units M536  and M537 (Appendix 3). The same applies to lightning protection.  (8) The Lessee shall make monthly advance payments for the operating costs which, insofar as  these are not the operating costs designated as “Basic Infrastructure Costs,” shall be  determined as follows:    For each calendar year, the Lessor shall estimate in advance a budgeted amount of the  operating costs and shall invoice the Lessee 1/12 plus VAT of this amount as an advance  operating cost payment in advance on a monthly basis.    (9) After the end of the settlement period (calendar year), the Lessor shall determine all  operating costs incurred during the settlement period as part of the statement of operating  costs. The Lessor shall compare the operating costs actually incurred with the advance  operating cost payments made by the Lessee and shall notify the Lessee of the result by  way of the statement of operating costs.    (10) Any difference between the advance payment amount and the settlement amount in favor of  the Lessor/Lessee shall be settled by the Lessor/Lessee within [***] months after receipt of  the statement of account by the Lessee plus the VAT applicable at the time of performance.    (11) Objections to the statement of account must be asserted by the Lessee in writing with the  Lessor within [***] months of receipt thereof. Otherwise, any objections to the correctness of  the statement of account shall be excluded, unless the Lessee is not responsible for the  delayed assertion, or the Lessor has not expressly pointed out this exclusion period and the  consequences of its expiration in the statement of account.  The Lessor shall allow the Lessee to inspect the accounting documents at the Lessor’s  business premises during normal business hours at the Lessee’s request and after prior  agreement on a date within [***] months after receipt of the statement of account.                    Page 14 of 32     

 

(12) In the event that the Lessee moves out during the settlement period, the apportionment at  the next invoice due shall, in case of doubt, be in the ratio of the lease period to the  settlement period.    (13) The advance payment amounts current at the commencement of the Agreement are  attached to this Agreement as Appendix 5.2). The Parties agree that Appendix 5.2) shall  not be amended and a new Appendix shall not be added to the Agreement in case of a  change of the advance payment amounts, but that a mere notification of the change (e.g. in  the form of an invoice) by the Lessor shall be sufficient.    (14) The Lessor shall provide the Lessee with the statement of account no later than the end of  the [***] month after the end of the settlement period, after it has received all the documents  and information required for the preparation of the statement of operating costs. After  expiration of this period (these periods), the assertion of any subsequent claims by the  Lessor shall be excluded, unless the Lessor is not responsible for the late assertion.    § 9  Operator responsibility, liability of the Lessee    (1) The Lessee shall, at its own expense, create all the conditions for the legally compliant  operation of its business in conformity with the law (operator responsibility).  The Lessee shall comply with any requirements imposed by the trade supervisory authority  or other bodies at its own expense, insofar as such requirements are specifically related to  the Lessee’s business or its activities in the Leased Property, even if they are directed  against the Lessor. § 2 (2) of this Lease Agreement shall remain unaffected.  The Lessee shall conduct its business in the Leased Property in accordance with the  applicable statutory regulations and in accordance with the requirements of national and  international authorities.                      Page 15 of 32   

 

(2) The Lessee shall indemnify the Lessor against all claims asserted by third parties on  account of the Lessee’s operator responsibility vis-à-vis the Lessor. § 15 (1) of this  Agreement shall remain unaffected.    (3) The Lessee shall be responsible for any culpable damage to the Leased Property and the  building as well as to all facilities and equipment belonging to the building or the premises if  and to the extent that the damage was caused by the Lessee or its bodies, employees,  subtenants, visitors, suppliers or service providers commissioned by the Lessee, if such  persons gained access to the building at the Lessee’s instigation or with its approval. The  Lessee shall be responsible for proving that there was no fault or negligence on its part  insofar as damage to the Leased Property is concerned.    (4) If, due to blockage, the leaving open of water taps or similar events, a flood or other damage  to the building, objects or third parties, the Lessee shall, insofar as the event was caused in  the Leased Property, be responsible for the repair of the damage and the elimination of all  consequential damage resulting therefrom. This shall not apply if the damage is attributable  to the Lessor or third parties who have entered the Leased Property at the Lessor’s  instigation or with its approval.    (5) Claims for compensation by the Lessor pursuant to § 548 (1) BGB due to contamination of  the Leased Property or the building caused by the Lessee or its subtenants or other  persons entering or driving onto the Leased Property with the knowledge of the Lessee  shall become statute-barred 18 months after the return of the Leased Property.  Contamination in the sense of this clause refers to harmful environmental effects and  pollution of the soil, buildings, parts of buildings, paved outdoor facilities or groundwater.  Contamination in this sense refers, in particular, also to harmful changes to the soil and  contaminated sites within the meaning of § 2 (3) and (5) of the German Federal Soil  Protection Act (BBodSchG).                                        Page 16 of 32    

 

§ 10  Warranty, liability of the Lessor    (1) The Lessee is aware that the Leased Property is located on the premises of an industrial  park and that the use of the Leased Property may be impaired in a manner customary for  an industrial park, for example by emissions from neighboring users or by work on supply  lines, roads and neighboring buildings and properties.    (2) The Lessor’s strict liability for damages for initial defects is excluded.    (3) If the Lessor defaults in remedying the defect, the Lessee may remedy the defect itself and  demand reimbursement of the expenses required for this purpose.    (4) The Lessee shall only be entitled to a rent reduction under the condition that a reasonable  period of time set by the Lessee for the Lessor to remedy the defect has elapsed unused.    (5) Claims for damages by the Lessee, unless excluded under this Agreement, including those  arising from pre-contractual obligations and tort, may only be asserted if the Lessor has  acted culpably. In the event of a breach of non-essential contractual obligations, however,  such claims may only be asserted if they are based on intent or gross negligence on the part  of the Lessor or its vicarious agents. Material contractual obligations (cardinal obligations)  are obligations the fulfillment of which makes the proper execution of the Agreement  possible in the first place and the observance of which the Party to the Agreement regularly  relies on and may rely on. The Lessor’s liability for damages shall be limited to foreseeable,  typical damage. If the Lessor has covered the above typical risk of damage with insurance,  liability for damages shall be limited to the sum insured, unless the insurer can invoke its  exemption from performance in whole or in part. The sum insured shall at least correspond  to the requirements pursuant to § 14 (1).                                  Page 17 of 32     

 

(6) All exclusions and limitations of the Lessor’s liability contained in this Agreement shall also  apply in favor of the Lessor’s bodies, representatives and vicarious agents.    (7) All exclusions and limitations of liability of the Lessor, its organs, representatives and  vicarious agents contained in this Agreement shall apply neither in the case of intent or in  the case of injury to life, body or health.    § 11  Maintenance, repair and cosmetic repairs, structural and   technical modifications    (1) In accordance with the negotiations held on November 23, 2021, the Lessor shall only be  responsible for the maintenance (including servicing and inspection) and repair of the  Leased Property within the limits of its definition pursuant to § 1 of the Lease Agreement,  i.e. of the roof and framework (only to the extent described in Appendix 1 and Appendix 2.1),  the building shell and the load-bearing components (including windows and exterior doors)  and the fixtures, fittings and equipment of the Leased Property described in Appendices  2.1) and 2.2), as well as the drainpipes and stormwater pipes pursuant to § 1 (3) of this  Agreement, as well as to maintain and repair the circulation and ancillary areas (marked  “gray” in Appendix 1)) and other common technical facilities, installations and areas,  including the common area. Major maintenance and repair work to be carried out by the  Lessor, i.e. such work as may have a significant effect on the Lessee’s operations, shall be  coordinated between the Lessor and the Lessee well in advance. Prior coordination is not  required if there is an imminent danger.    (2) In accordance with the statements in the preliminary remarks of this Lease Agreement, the  Lessee shall be entitled at its own expense for the maintenance (including servicing and  inspection) and repair of the technical facilities and equipment existing in or on Buildings 536  and 537, insofar as these are not listed in Appendices 2.1) and 2.2) as part of the Leased  Property, and shall only be obligated to maintain and repair the same insofar as                                     Page 18 of 32       

 

such obligation arises from the operator responsibility pursuant to § 9 of this Lease  Agreement or a risk to the Leased Property or personal injury cannot be ruled out. In  particular, all work required by law and/or necessary according to the manufacturer’s  specifications to maintain the operational readiness and operational safety of these fittings,  facilities and equipment shall be carried out by the Lessee at its expense. The same shall  apply in particular to the maintenance (including servicing and inspection) and repair of the  installations and conversions, fixtures and equipment carried out by the previous tenants and  by the Lessee itself.    (3) Cosmetic repairs are to be carried out neither by the Lessor nor by the Lessee.    (4) The Lessor shall give the Lessee written notice of any modernization measures (§ 555 c  BGB) to be carried out in the Leased Property with a reasonable period of notice prior to  commencement of such measures in the Leased Property. As a rule, the Parties consider  a period of three months to be reasonable. The Lessee’s special right of termination in the  event of modernization measures (§ 555e (1) BGB) is excluded by mutual agreement.    (5) The Lessee shall treat with care the sanitary facilities, locks, lighting fixtures, built-in  furniture, kitchens, external blinds and thermostats provided by the Lessor, insofar as these  exist. Defective light bulbs shall be replaced by the Lessee. The Lessee shall keep the  Leased Property free of vermin at its own expense and maintain sanitary facilities and  social spaces, insofar as they exist in the Leased Property, in a proper, in particular  hygienic, condition at all times and shall clean the leased areas used only by itself (excluding  common areas) regularly and shall properly clean the windows at least twice a year.    (6) With the exception of the extension of the Leased Property permitted within the scope of  the purpose of the lease pursuant to § 2 (1) of this Lease Agreement, the Lessee shall be  entitled to make structural and/or technical changes to the Leased Property as defined in §  1 of this Lease Agreement itself only with the prior consent of the Lessor, to which the  Lessee shall have no claim. To obtain consent on the part of the                                    Page 19 of 32     

 

Lessor, the Lessee must submit a detailed description of the planned structural change,  including all relevant descriptions, a planning diagram and a presentation of the effects of  the structural change in terms of permit requirements, insurance requirements, any  disruptive environmental impacts such as noise or other emissions and the functioning of the  building as a whole. Any declarations of consent by the Lessor shall always be issued, even  if this is not repeated in the declaration of consent, subject to any necessary official  approval, the procurement of which shall be the responsibility of the Lessee at its own  expense. The Lessee shall be liable to the Lessor regardless of fault for any damage  occurring during or as a result of the structural change, including effects on other leased  areas, and for compliance with building regulations, and shall indemnify the Lessor in full in  this respect. This shall also apply if defects or other impairments of the Leased Property or  other leased units occur as a result of the structural change. The costs of any structural  change, including all planning and permit costs, shall be borne by the Lessee.  All construction and/or technical changes to be made by the Lessee, insofar as they affect  the Leased Property itself, must be sufficiently documented in writing, including the type  and scope of the changes, prior to implementation of the measure by way of supplementary  management.    § 12  Company signs    (1) The Lessee may, taking into account the circumstances at the site and after consultation  with the Lessor, affix its company name itself at its own expense only on those buildings of  which it is the sole user. It shall bear the costs for affixing these signs. If official permits are  required for the affixing of these signs, the Lessee shall obtain them and bear the costs  incurred thereby. The Lessee shall be responsible for ensuring the safety of the fixtures  which it attaches.    (2) The type, size and location of (display) boxes or boards for internal communication and  information that are installed outside the areas used exclusively by the Lessee shall also be  coordinated between the Lessee and the Lessor.                            Page 20 of 32       

 

(3) If the removal of the company signs pursuant to subsections (1) or (2) is necessary for work  on the site or on the Leased Property, the Lessee shall bear the costs of the removal,  storage and reattachment, including any repairs to the fixture necessitated thereby. Upon  termination of the lease, the Lessee shall remove the company signs at its own expense  and remove at its own expense any damage caused by attaching, operating and removing  them.    (4) If the Lessor erects uniform company signs, the Lessee shall share appropriately in the  costs of erecting and maintaining such signs.    § 13  Technical building equipment, supply and disposal    (1) The Leased Property shall have a technical connection for the supply of electrical power,  drinking water and data communication to the currently existing supply and disposal facilities  of the site. The Lessee shall itself and at its own expense ensure the supply of the Leased  Property with the energy and media required for its use by concluding separate energy  supply contracts with the Lessor or with third parties. The Lessee shall itself provide for the  adequate heating of the Leased Property. If increased connection capacities or connections  for other energy or media are required in addition to the connection available at the  commencement of the lease, the Parties shall enter into discussions on this matter; the  Lessee shall have no claim to the establishment of increased connection capacities or  further connections.    Wastewater disposal is not the subject of this Lease Agreement and is therefore not owed by  the Lessor under this Lease Agreement, but is governed by the Wastewater Agreement  between the Lessor and the Lessee dated March 25/April 12, 2021 (Appendix 8), as  amended.    (2) The Lessee shall use the supply and disposal lines installed in the Leased Property, e.g.  for electricity, gas, nitrogen, compressed air and water/wastewater, only to the extent that no  overloads occur.                                  Page 21 of 32     

 

The Lessee may cover any additional demand by extending the lines and necessary  technical equipment at its own expense after prior written consent of the Lessor, which may  only be refused for good cause.    (3) If, as a result of a legally mandatory conversion of a type of energy supply, it is necessary to  convert equipment or installations, parts of installations and ancillary equipment belonging to  the Lessee, the costs of converting these equipment and installations, parts of installations  and ancillary equipment shall be borne by the Lessee. Any claims for compensation on the  part of the Lessee as well as claims for a reduction of the rent shall be excluded in this case.    (4) Prior to setting up shelves, heavy machinery, apparatuses and safes in the Leased  Property, the Lessee shall inquire with the Lessor about the permissible load limits of the  floor and the floor ceilings and obtain the Lessor’s prior written consent. The Lessee shall  be liable for any damage caused by non-compliance with these provisions; any liability on  the part of the Lessor shall be excluded. If machinery causes disturbances or other  detrimental effects on the building, vibrations, cracks, etc., the Lessor may revoke the  permission granted or impose subsequent conditions. The Lessor shall also not be liable for  the suitability of the Leased Property for the installation or connection of equipment.      § 14  Insurance      (1) From the time of handover, the Lessor shall maintain all-risk property insurance, including  fire insurance for the building, as well as liability insurance with a minimum coverage of €10  million. The costs of these insurance policies form – if applicable, on a pro rata basis – part  of the operating costs pursuant to § 8 of this Agreement.    (2) The Lessee shall be obliged to take out, at its own expense, liability insurance providing  coverage for damage to rented property with a minimum sum insured of €10 million from the  commencement of the lease, as well as all insurance policies required for operation pursuant  to § 2 of this Agreement. Global insurance policies or policies that provide for a deductible  on the part of the Lessee fulfill this requirement.                            Page 22 of 32       

 

In the event of an increase in the insured risk, the Lessee shall extend its insurance  coverage without being requested to do so.    (3) All insurance policies shall be maintained during the term of the lease, either through a  continuation of the respective insurance policy or by taking out new comparable insurance  policies. The sole decisive factor is that insurance coverage must exist for the entire term.    (4) Upon request of the other Party, each Party shall submit certificates of the insurance  policies it is required to take out, showing the amount of the deductible, and shall provide  proof of premium payment on request at any time.    (5) Each Party agrees to draw the other Party’s attention without delay to any lacking or  insufficient general or special insurance coverage which it has identified. This shall apply in  particular to circumstances which have or may have the effect of changing or increasing the  risk, in particular in the case of installations, structural measures or changes of use.    (6) The Lessee shall notify the insurer and the Lessor immediately of any case of damage and  shall ensure that the site of the damage – wherever possible and reasonable – remains  unchanged prior to inspection by the insurer. Notwithstanding the foregoing, the Parties shall  be obligated to take such measures as are necessary to mitigate the damage or to reduce  consequential damages. The Parties shall carry out these measures in coordination with  each other and with the respective insurer.    § 15  Termination of the lease, obligation to surrender,  restoration of the original condition    (1) Upon termination of the lease, the Lessee shall return the Leased Property in accordance  with the provisions of this Agreement and otherwise in a broom-clean condition and free of  substances that are likely to cause hazards, significant disadvantages or significant  nuisances                                   Page 23 of 32       

 

within the meaning of § 3 of the German Federal Emissions Control Act for individuals or the  general public (hereinafter collectively referred to as “Contamination”), insofar as they were  caused by the Lessee.    If there is Contamination of the Leased Property or of fixtures, fittings and equipment that  are not part of the lease, the Lessee shall indemnify the Lessor in full, even during the term  of the lease, if a claim is made against the Lessor for investigation, remediation or other  measures relating to the Contamination, as well as against any claims by third parties in  connection with such Contamination. However, this shall only apply insofar as the Lessor  proves that the contamination of the Leased Property was caused by the Lessee after the  commencement of this contractual relationship. This proof of causation by the Lessor shall  not be required with respect to the fixtures, fittings and equipment that are not part of the  lease, in particular those taken over by the Lessee from the previous tenants.    (2) In accordance with the statements in the preliminary remarks of this Lease Agreement, the  Lessee shall be obligated upon termination of the lease to    - to remove all fittings, installations and equipment located in the Leased Property,  unless these are identified as part of the Leased Property in Appendices 2.1) and  2.2) to the Lease Agreement, including their connections to the Leased Property, in  a professional manner at its own expense, even if these fittings, installations and  equipment were not introduced to the Leased Property by the Lessee and  regardless of whether this was done before or during the lease established by this  Lease Agreement. The Parties clarify that the underground pipes as defined in § 1  (3) of this Lease Agreement and stormwater pipes may remain in the Leased  Property.    - to restore the Leased Property to the structural condition as set forth in Appendix 1)  and Appendices 2.1) and 2.2), even if the structural or technical changes have not  been made by the Lessee and regardless of whether this was done before or during  the lease established by this Lease Agreement; and    - to remove its movable inventory at its own expense                       Page 24 of 32     

 

unless the Lessor has waived this in writing in an addendum to this Lease Agreement.    (4) If the Lessee fails to comply with its obligation to return the Leased Property in due time  pursuant to subsection (1), it shall pay to the Lessor, on the basis of a daily settlement per  day of the delayed return, 1/30 of the last monthly net base rent paid, plus 1/30 of the last  monthly advance payment of operating costs paid, plus the statutory VAT applicable at the  time of performance. The assertion of further damages by the Lessor remains reserved.    (5) The Parties shall prepare a written handover report on the return of the Leased Property.    (6) The Lessor agrees to reimburse the Lessee in the event that the Lease Agreement is  terminated at the end of December 31, 2031 for the documented costs for measures  pursuant to § 15 (2) of this Lease Agreement up to an amount of € [***] (in words [***] euros)  (“Reimbursement Amount”). In the event that the Lease Agreement is terminated at the end  of December 31, 2036 or at the end of December 31, 2041, the maximum Reimbursement  Amount in both cases shall be € [***] (in words: [***] euros).      § 16  Force majeure      Insofar and as long as a Party is prevented from fulfilling its contractual obligations for  reasons of force majeure, it shall be released from such fulfillment. It shall immediately notify  the other Party of the circumstances of force majeure and endeavor to remedy such  circumstances. To the extent necessary and possible, the Parties shall agree on necessary  adjustment measures. The Parties clarify that force majeure shall be understood to mean an  extraordinary event of external origin, unforeseeable and uncontrollable, which cannot be  prevented or averted even by the utmost care, e.g. lightning, earthquake, war, warlike  conditions, floods etc.                                    Page 25 of 32     

 

§ 17  Confidentiality      (1) The Parties mutually agree to keep confidential any information they receive in connection  with the conclusion of this Lease Agreement and its performance, including the economic  framework conditions and the provisions of this Lease Agreement as well as any business  and trade secrets that may become known. This means that corresponding information may  not be disclosed to third parties without the prior written consent of the other Party.    Excluded from this is the disclosure of information to third parties engaged by one Party for  the performance of the Agreement, but only to the extent that it is absolutely necessary for  such performance.    However, it is a prerequisite that such third parties (e.g. lawyers, tax consultants, brokers,  experts, tradespeople etc.) are in turn obliged to maintain confidentiality.    The above duty of confidentiality shall apply for a period of up to [***] years after termination  of the lease.    (2) Excluded from the duty of confidentiality pursuant to subsection (1) shall be such information  which the Parties have already received prior to the conclusion of the lease, regardless of its  performance, or such information which may be obtained by one of the Parties from  generally accessible sources without either of the Parties having brought this about by  violating the duty of confidentiality.    The duty of confidentiality shall not apply if one of the Parties discloses the information  necessary for this purpose on the basis of a statutory or official order or in legal proceedings  in order to safeguard its legitimate interests.                                      Page 26 of 32     

 

§ 18  Collateral      (1) In order to secure all claims of the Lessor against the Lessee arising from this Lease  Agreement, the Lessee shall, within 2 months of signing this Agreement, provide on first  demand a directly enforceable guarantee of a bank licensed to do business in accordance  with the attached sample (Appendix 7) for an amount corresponding to 3 times the monthly  base rent at the beginning of the lease, plus advance payment of operating costs at the  beginning of the lease, plus VAT.    (2) If the Lessee fails to provide a proper lease guarantee within the agreed period, after setting  a reasonable grace period, the Lessor shall be entitled to terminate the lease without notice  for good cause.    (3) The guarantee shall be returned by the Lessor to the Lessee at the end of 6 months after  the termination of the lease, unless the Lessor asserts claims from the lease secured by the  guarantee against the Lessee or the guarantor.      § 19  Subletting, transfer of use  and partial transfer      (1) The Lessee shall only be entitled to transfer the use of the Leased Property to a third party,  and in particular to sublet it, with the Lessor’s prior written consent. The Lessor shall refuse  its consent only for good cause. Good cause within the meaning of this provision shall be  deemed to exist, in particular, if the provisions of § 3 of this Agreement are violated or if the  third party is in a competitive relationship with the Lessor with its services. The Lessor now  agrees to subletting to affiliated companies pursuant to § 15 of the German Stock  Corporation Act (AktG).    (2) In the event of the transfer of use to a third party, the Lessee shall be liable for the latter as  its vicarious agent.                            Page 27 of 32     

 

§ 20  Consideration/prevention of hazards      (1) The Parties agree that the above provisions are only practicable if they take consideration of  the respective interests of the other Party, with the involvement of the other companies on  site, and agree in particular to find mutually agreeable solutions to problems which cannot be  foreseen and regulated in detail by a contract.    (2) This shall apply, in particular, to measures which the Parties carry out on their own  responsibility and at their own expense in accordance with the provisions of this Agreement  and to official and other requirements which can only be met by way of mutual agreement.    (3) In case of imminent danger, the Lessee shall comply with the instructions of the plant  security provider and the plant fire department. It shall also impose this obligation on the  personnel employed by it and on third parties commissioned by it.    (4) The placement and storage of objects of any kind (boxes, goods, etc.) outside the Leased  Property, in particular in shared circulation routes, is not permitted. If, in exceptional cases,  the Lessor grants its consent to such storage, the Lessee shall nevertheless be liable for  any damage resulting therefrom.    (5) Packaging material or similar waste resulting from commercial activities may not be  disposed of in the general household waste containers, but must be disposed of in the  supply facilities designated for this purpose by the Lessor.    (6) The Lessee shall comply with the parking regulations (Appendix 6), ensure that its  employees and visitors comply with the parking regulations and support the Lessor in  enforcing the parking regulations to the best of its ability.                        Page 28 of 32     

 

§ 21  Completeness, written form      (1) This Agreement contains all agreements of the Parties. No additional agreements, ancillary  agreements and assurances exist. If, contrary to the preceding sentence, additional  agreements, ancillary agreements or assurances do exist, they are hereby revoked.    (2) Amendments and supplements to this Agreement and its Appendices as well as all  declarations of intent under this Agreement must be made in writing to be effective. This  shall also apply in the event of an amendment to this written form clause.    (3) The Parties are aware of the statutory written form requirement for lease agreements with a  term longer than one year (§§ 550 (1), 126 (1) and (2) in conjunction with § 578 (2) (1) (1)  BGB). They therefore mutually agree, upon mutual request of the other Party, to perform all  acts and make all declarations necessary to comply with the statutory written form  requirement. This provision shall apply not only to the execution of the main Lease  Agreement and its Appendices, but also to all ancillary agreements, addenda, amendments  or supplements. It shall not bind a subsequent purchaser of the property on which the  Leased Property is located; § 566 (1) BGB shall be excluded to this extent.    (4) The Agreement shall be executed in duplicate; each Party shall receive one copy.      § 22  Other provisions      (1) The Lessor, its agents, experts and interested parties may enter the Leased Property  during business hours, after due notice and taking into account the legitimate interests of the  Lessee, for the purpose of inspecting its condition, leasing it to a subsequent tenant, sale or  otherwise for good cause.    Insofar as regulatory requirements (such as GMP regulations) apply to parts of the Leased  Property, entry shall only be permitted in compliance with such requirements, insofar as                             Page 29 of 32     

 

the Lessee has provided timely and comprehensive information about the specific  requirements and the necessary measures.    In case of imminent danger, they shall be permitted access at any time of the day or night. In  this case, the Lessee shall provide the appropriate means of access and, if the Lessee is  not present, shall deposit keys in a quickly accessible location known to the Lessor.    In addition, the Lessor and its agents shall be entitled to enter the Leased Property at any  time of day or night in coordination with the Lessee (coordination documented, for example,  by issuing an access authorization card) in order to access energy rooms, communication  nodes, main and floor telephone exchanges, main and floor fire alarm exchanges, battery  system rooms and electro-acoustic systems (ELA) including the infrastructure required for  this purpose as well as other rooms serving the supply of the Leased Property.    (2) The Lessee shall be responsible for ensuring traffic safety within the Leased Property. The  Lessee shall be responsible for ensuring safety within the leased areas used exclusively by  it as well as the technical areas, insofar as these are also used exclusively by the Lessee.  Insofar as technical areas are used by both the Lessee and the Lessor (§ 1 (1) of the Lease  Agreement), both Parties shall be equally liable for traffic safety and shall be jointly and  severally liable to third parties in the event of a breach of the traffic safety obligation.    (3) All Appendices form an integral part of this Lease Agreement.    (4) As of the date of its entry into force, this Lease Agreement shall replace all existing oral  and/or written agreements between the Parties concerning the transfer of the Leased  Property described in more detail in § 1 of this Lease Agreement. The Old Lease existing  between the Parties dated July 1, 2021 shall have ended as agreed with effect from the end  of November 30, 2021, 12:00 a.m. the following day. No return of the Leased Property to  the Lessor, even for a limited period of time, has taken place, as the Lessee continues to  use the Leased Property without interruption.                                      Page 30 of 32     

 

(5) This Agreement is independent of any other lease agreements existing between the Parties.    (6) The Wastewater Agreement between the Lessor and the Lessee dated March 25/April 12,  2021 is an integral part of this Lease Agreement and is attached to this Agreement as  Appendix 8).    (7) The law of the Federal Republic of Germany shall apply to this Agreement and the lease  governed by it. Insofar as translations are made of this Agreement, the German version shall  be controlling.    (8) Marburg/Lahn is agreed as the place of jurisdiction for all disputes arising from this  Agreement.    (9) Should any provision of this Agreement or any future newly included provision be invalid or  unenforceable in whole or in part or lose its validity or enforceability at a later date, or should  a gap be found in this Agreement, this shall not affect the validity of the remaining  provisions. In place of the invalid or unenforceable provisions or to fill the gap, an  appropriate provision shall be agreed in due form which, to the extent legally permissible,  shall come as close as possible to what the Parties intended or would have intended  according to the meaning and purpose of the Agreement if they had considered the point in  question.    (10) The Lessor assumes no liability for any complete or partial competitive overlaps between  the business operations of the Lessee and those of other tenants which exist or which will  arise in the future. No protection against competition is granted.    (11) The Appendices to this Agreement are:    Appendix 1)  List of leased areas    Appendix 2.1)  List of fixtures, installations and equipment, facilities    Appendix 2.2)  Building description of the Leased Property,   equipment description of the Leased Property                  Page 31 of 32     

 

Appendix 3)  Lessee’s share of total area of Building   M536 and Building M537 in m2    Appendix 4)  Monthly net base rent    Appendix 5.1)  Operating costs    Appendix 5.2)  Advance payment of operating costs    Appendix 6)  General Entry and Parking Regulations    Appendix 7)  Sample lease guarantee    Appendix 8)  Wastewater Agreement dated March 25/April 12, 2021 including   Addendum No.1 dated December 14, 2021    Appendix 9)  Refurbishment of wastewater pipes          Marburg, _____19/01/2022_____ Marburg, _____19/01/2022_____      Pharmaserv GmbH BioNTech Manufacturing Marburg   GmbH                             [***]               [***]         [***]               [***]                 [***]  ____________________________ ____________________________  Name Name         [signature]      [signature]  ____________________________ ____________________________  Signature Signature           [***]      [***]  ____________________________ ____________________________  Name Name         [signature]      [signature]  ____________________________ ____________________________  Signature Signature      Page 32 of 32     

 

Appendix 1)          [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]        

 

Appendix 1.1)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 2.2)      [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 3)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 4)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 5.1)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]         

 

Appendix 6)      [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 7)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

APPENDIX 8    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

Appendix 1 to the Wastewater Agreement (BioNTech)    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     

 

      [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]     Appendix 1 to the Wastewater Agreement (BioNTech)                                                                                                   

 

  Appendix 1 to the Wastewater Agreement (BioNTech)      [***]  [***]  [***]  [***]  [***]  [***]  [***]                     

 

Appendix 3 to the Wastewater Agreement with BioNTech    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  

 

Appendix 3 to the Wastewater Agreement with BioNTech    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  .                         

 

  Appendix 1 to the Wastewater Agreement (BioNTech) – Addendum 1    [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]  [***]

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