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Exhibit 10.13    
    

SIRTRIS
PHARMACEUTICALS, INC.

100 BEAVER STREET, SUITE 240

WALTHAM, MA 02453 

August 16,
2005 

Peter
Elliott

[Address] 

Dear
Peter: 

        This
letter agreement ("Agreement") will confirm our offer to you of employment with Sirtris Pharmaceuticals, Inc. (the "Company"), under the terms and conditions that follow: 

        1.    Position and Duties.    

        (a)    The Company.    Effective September 7, 2005, (the "Effective Date"), you will be
employed by the Company, on a full-time basis, as its Head of Development, subject to the direction and control of the Chief Executive Officer of the Company. Subject to the discretion of
the Chief Executive Officer, your duties will include oversight of the non-clinical development activities of the Company, as well as Phase I clinical trials. You agree to perform the
duties of your position and such other duties as reasonably may be assigned to you from time to time. You also agree that while employed by the Company, you will devote one hundred percent (100%) of
your business time and your reasonable commercial efforts, business judgment, skill and knowledge exclusively to the advancement of the business and interests of the Company and to the discharge of
your duties and
responsibilities for it. You may, however, (i) serve as an officer, director, trustee or committee member of any religious, professional, civic, charitable or educational organization,
(ii) with the prior approval of the Chief Executive Officer of the Company, serve as a director of up to one corporation whose businesses are not competitive with the Company, and
(iii) engage in, and devote time and effort to, any and all personal investments (which shall in no event include being an officer or principal shareholder of any public or private company)
unrelated to the business or affairs of the Company, in each case so long as such activities do not require more than ten (10) hours per week of your time or otherwise interfere with your
obligations to the Company hereunder or compete or conflict in any way with the business of the Company. You will be considered for the position of Head of Research and Development of the Company
within two years of the Effective Date, with such decision to be based on your performance and the Company's progress, as evaluated by progression to the clinic and pharmaceutical partnerships, and to
be made in the sole discretion of the Board of Directors of the Company (the "Board"). During your employment with the Company, you may provide consulting services to other Persons only with the prior
approval of the Chief Executive Officer and the Board. 

        2.    Compensation and Benefits.    During your employment, as compensation for all services
performed by you for the Company and subject to your performance of your duties and responsibilities for the Company, pursuant to this Agreement or otherwise, the Company will provide you the
following pay and benefits: 

        (a)    Base Salary.    The Company will pay you a base salary at the rate of Two Hundred
Seventy Five Thousand Dollars ($275,000) per year. Such amount shall be payable in accordance with the regular payroll practices of the Company for its executives, as in effect from time to time, and
subject to increase from time to time by the Board in its discretion. 

        (b)    Bonus Compensation.    You will receive a one-time signing bonus of twenty
thousand dollars ($20,000) within thirty (30) days after the Effective Date, which amount shall be repaid to the Company within thirty (30) days of the termination of your employment by
the Company for "Cause" or by you other than for "Good Reason" if such termination occurs within one year from the Effective Date. In addition, during your employment, you may be considered annually
for a 

 

bonus
in addition to your base salary. Bonus compensation in any year, if any, will be determined by the Board based on your performance and that of the Company, in accordance with a general executive
bonus program to be established and agreed upon by you and the Board's Compensation Committee. 

        (c)    Stock Options.    Subject to approval by the Board of Directors, at the next regular
meeting of the Board following the Effective Date, but in any case no later than October 15, 2005, you will be awarded the following stock options: 

        (i)    An
option to purchase 1,250,000 shares of the common stock of the Company at the then fair market value of the Company's common stock (the "Employment Option"). The
Employment Option will vest as follows: twenty-five percent (25%) of the shares subject to the Employment Option shall vest on the one-year anniversary of the Effective Date,
provided you are employed by the Company on that date, and the remainder of the shares subject to the Employment Option shall vest ratably, on a quarterly basis, on the last date of each of the next
twelve (12) quarters thereafter, provided that you remain in the Company's employ at each such vesting date. 

        (ii)   An
option to purchase 100,000 shares of the common stock of the Company at the then fair market value of the Company's common stock (the "Performance Option"). The
shares subject to the Performance Option will vest in full upon the first dosing in man of a proprietary Sirtris dose form (defined as a dose form which is covered by a issued US patent or pending US
patent application) under a Company sponsored FDA IND. 

While
the determination of the fair market value of the Company's common stock is at the discretion of the Board of Directors, incentive stock options of the company are currently being priced at $.08
per share, which the Board of Directors has determined to be the current fair market value of the Company's common stock at its most recent meeting. In addition to the terms set forth above, the
Employment Option and Performance Option will be subject to the Company's standard terms of stock options and will be documented in one or more stock option agreements that you will receive promptly
following the date of issuance of the options. The Board may from time to time grant to you additional options in its discretion. 

        (d)    Participation in Employee Benefit Plans.    You will also be eligible to participate in
the Company's Medical and Dental Insurance Programs as well as the Life, AD & D, Short and Long Term Disability Plans and other benefit plans of the Company (or such greater benefits as are
generally made available to the Company's executive officers), except to the extent such plans are duplicative of benefits otherwise provided you under this Agreement
(e.g., severance pay) or under any other agreement. The Company currently pays for 85% of the cost of the Medical and Dental plans and 100% of the cost
of Life and AD & D insurance as well as Short and Long Term Disability Plans. In addition you will be eligible to participate in the Sirtris 401 (k) Plan. All of the Company benefit
plans will be subject to the plan terms and the applicable Company policies and are subject to modification at the discretion of the Board. 

        (e)    Vacations.    You will accrue three weeks paid vacation per year (or such greater
amount as is generally made available to the Company's executive officers) in accordance with the Company's policies from time to time in effect and receive paid holidays (currently 11 per year) in
accordance with the Company holiday schedule. Vacation may be taken at such times and intervals as you shall determine, subject to the business needs of the Company, and otherwise shall be subject to
the policies of the Company, as in effect from time to time. 

        (f)    Business Expenses.    The Company will pay or reimburse you for all reasonable business
expenses incurred or paid by you in the performance of your duties and responsibilities for the Company, subject to any maximum annual limit and other restrictions on such expenses set by the 

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Company
and to such reasonable substantiation and documentation as it may specify from time to time. 

        3.    Confidential Information, Non-Competition and Proprietary
Information.    Your employment with the Company is conditioned upon and subject to your agreement to the Company's Confidentiality, Non-Competition and
Proprietary Information Agreement, to be executed by you simultaneously herewith. It is understood and agreed that breach by you of the Confidential Information, Non-Competition and
Proprietary Information Agreement shall constitute a material breach of this Agreement. 

        4.    Termination of Employment.    Your employment under this Agreement shall continue until
terminated pursuant to this Section 4. 

        (a)   The
Company may terminate your employment for "Cause" upon written notice to you setting forth in reasonable detail the nature of the Cause. The following, as determined
by the Board in its reasonable judgment, shall constitute Cause for termination: (i) your willful failure to perform, or gross negligence in the performance of, your material duties and
responsibilities to the Company and its Affiliates which is not remedied within thirty (30) days of written notice thereof; (ii) material breach by you of any material provision of this
Agreement or any other agreement with the Company or any of its Affiliates which is not remedied within thirty (30) days of written notice thereof; (iii) fraud, embezzlement or other
dishonesty with respect to the Company and any of its Affiliates, taken as a whole, which, in the case of such other dishonesty, causes or could reasonably be expected to cause material harm to the
Company and any of its Affiliates, taken as a whole; or (iv) your conviction of a felony. 

        (b)   The
Company may terminate your employment at any time other than for Cause upon written notice to you. 

        (c)   You
may terminate your employment for "Good Reason" upon written notice to the Company setting forth in reasonable detail the nature of the Good Reason. The following
shall constitute Good Reason for termination by you: (i) material diminution in the nature or scope of your responsibilities, duties or authority, provided that none of the following shall
constitute "Good Reason": (x) the Company's failure to continue your appointment or election as a director or officer of any of its Affiliates, (y) any diminution in the nature or scope
of your responsibilities, duties or authority that is reasonably related to a diminution of the business of the Company or any of its Affiliates, other than
any such diminution resulting from the sale or transfer of any or all of the assets of the Company or any of its Affiliates, or (z) the hiring of a head of Research and Development for the
Company other than you after the second anniversary of the Effective Date and any resultant change in your responsibilities, duties or authority reasonably related to such hire; (ii) a
reduction in your base salary other than one temporary reduction of not more than 120 days and not in excess of 20% of your base salary in connection with and in proportion to a general
reduction of the base salaries of the Company's executive officers; (iii) failure of the Company to provide you the salary or benefits in accordance with Section 2 hereof after thirty
(30) days' notice during which the Company does not cure such failure; (iv) relocation of your office more than thirty-five (35) miles from the location of the
Company's principal offices as of the Effective Date or (v) the termination of Christoph Westphal as Chief Executive Officer of the Company without cause within one year of the Effective Date. 

        (d)   You
may terminate your employment with the Company other than for Good Reason at any time upon one month's notice to the Company. 

        (e)   This
Agreement shall automatically terminate in the event of your death during employment. The Company may terminate your employment, upon notice to you, in the event
you become disabled during employment and, as a result, are unable to continue to perform 

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substantially
all of your material duties and responsibilities under this Agreement for one-hundred and twenty (120) days during any period of three hundred and
sixty-five (365) consecutive calendar days. If any question shall arise as to whether you are disabled to the extent that you are unable to perform substantially all of your
material duties and responsibilities for the Company and its Affiliates, you shall, at the Company's request and expense, submit to a medical examination by a physician selected by the Company to whom
you or your guardian, if any, has no reasonable objection to determine whether you are so disabled and such determination shall for the purposes of this Agreement be conclusive of the issue. If such a
question arises and you fail to submit to the requested medical examination, the Company's determination of the issue shall be binding on you. 

        5.    Severance Payments and Other Matters Related to Termination.    

        (a)    Termination pursuant to Section 4(b), 4(c) or 4(e).    Except as provided in Section 5(c) below, 

        (i)    in
the event of termination of your employment following the Effective Date by the Company other than for Cause pursuant to Section 4(a) of this Agreement, or in
the event of termination of your employment following the Effective Date by you for Good Reason pursuant to Section 4(c) of this Agreement, the Employment Option shall vest as of the date of
termination (notwithstanding anything to the contrary in Section 2(c) of this Agreement) with respect to an additional one year of vesting and
the Company will continue to pay you your base salary, at the rate in effect on the date of termination, for the period of six (6) months from the date of termination; or 

        (ii)   in
the event of your termination of employment as a result of your death or disability at any time pursuant to Section 4(e) of this Agreement, the Employment
Option shall vest as of the date of termination, which in the case of death shall be the date of death (notwithstanding anything to the contrary in Section 2(c) of this Agreement) with respect
to an additional one year of vesting, and, to the extent the Company's benefits do not include disability insurance benefits that will continue your base salary at 100% of the amount of such base
salary for the period of six months from the date of termination, the Company shall pay such amount at the time that your base salary would be otherwise paid as shall equal the amount by which 100% of
your base salary exceeds the disability insurance benefits, if any, actually paid to you. 

If
you are participating in the Company's group health plan and/or dental plan at the time your employment terminates (whether such termination is as described in (i) or (ii) above, and
you exercise your right to continue participation in those plans under the federal law known as COBRA, or any successor law, the Company will pay or, at its option, reimburse you, for the full premium
cost of that participation for six months following the date on which your employment with the Company terminates or, if earlier, until the date you become eligible to enroll in the health (or, if
applicable, dental) plan of a new employer. The Company will also pay you on the date of termination any base salary earned but not paid through the date of termination and pay for any vacation time
accrued but not used to that date. In addition, the Company will pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your employment. Any obligation of the
Company to provide you severance payments or other benefits under this Section 5(a) is conditioned on your signing an effective release of claims in the form provided by the Company (the
"Employee Release") following the termination of your employment, which release shall not apply to (i) claims for indemnification in your capacity as an officer or director of the Company under
the Company's Certificate of Incorporation, By-laws or agreement, if any, providing for director or officer indemnification, (ii) rights to receive insurance payments under any
policy maintained by the Company and (iii) rights to receive retirement benefits that are accrued and fully vested at the time of your termination. All severance payments will be in the form of
salary continuation, payable in accordance 

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with
the normal payroll practices of the Company, and will begin at the Company's next regular payroll period following the effective date of the Employee Release, but shall be retroactive to the date
of termination. You agree to provide the Company prompt notice of your eligibility to participate in the health plan and, if applicable, dental plan of any employer. You further agree to repay any
overpayment of health benefit premiums made by the Company hereunder. 

        (b)    Termination other than pursuant to Section 4(b) or 4(c).    In the event of any termination of your
employment, other than a termination by the Company pursuant to Section 4(b) of this Agreement, a termination by you for Good Reason pursuant to Section 4(c) of this Agreement, or a
termination as a result of your death or disability pursuant to Section 4(e) of this Agreement, the Company will pay you any base salary earned but not paid through the date of termination and
pay for any vacation time
accrued but not used to that date. In addition, the Company will pay you any bonus which has been awarded to you, but not yet paid on the date of termination of your employment. The Company shall have
no other obligation to you under this Agreement. 

        (c)   Except
for any right you may have under applicable law to continue participation in the Company's group health and dental plans under COBRA, or any successor law,
benefits shall terminate in accordance with the terms of the applicable benefit plans based on the date of termination of your employment, without regard to any continuation of base salary or other
payment to you following termination. 

        (e)   Provisions
of this Agreement shall survive any termination if so provided in this Agreement or if necessary or desirable to accomplish the purposes of other surviving
provisions, including without limitation your obligations under Section 3 of this Agreement and under the Confidentiality, Non-Competition and Proprietary Information Agreement. The
obligation of the Company to make payments to you or on your behalf under Section 5 of this Agreement is expressly conditioned upon your continued full performance of your obligations under
Section 3 hereof, under the Confidentiality, Non-Competition and Proprietary Information Agreement to be executed herewith, and under any subsequent agreement between you and the
Company or any of its Affiliates relating to confidentiality, non-competition, proprietary information or the like. 

        6.    Definitions.    For purposes of this agreement, the following definitions apply: 

        "Affiliates"
means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by management authority,
equity interest or otherwise. 

        "Person"
means an individual, a corporation, an association, a partnership, an estate, a trust and any other entity or organization, other than the Company or any of its Affiliates. 

        7.    Conflicting Agreements.    You hereby represent and warrant that your signing of this
Agreement and the performance of your obligations under it will not breach or be in conflict with any other agreement to which you are a party or are bound and that you are not now subject to any
covenants against competition or similar covenants or any court order that could affect the performance of your obligations under this Agreement. You agree that you will not disclose to or use on
behalf of the Company any proprietary information of a third party without that party's consent. 

        8.    Withholding.    All payments made by the Company under this Agreement shall be reduced
by any tax or other amounts required to be withheld by the Company under applicable law. 

        9.    Assignment.    Neither you nor the Company may make any assignment of this Agreement or
any interest in it, by operation of law or otherwise, without the prior written consent of the other; provided, however, that the Company may assign its rights and obligations under this Agreement
without your consent to one of its Affiliates or to any Person with whom the Company shall hereafter affect a reorganization, consolidate with, or merge into or to whom it transfers all or
substantially all of 

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its
properties or assets. This Agreement shall inure to the benefit of and be binding upon you and the Company, and each of our respective successors, executors, administrators, heirs and permitted
assigns. 

        10.    Severability.    If any portion or provision of this Agreement shall to any extent be
declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to
which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

        11.    Miscellaneous.    This Agreement, together with the Confidentiality,
Non-Competition and Proprietary Information Agreement, sets forth the entire agreement between you and the Company and replaces all prior communications, agreements and understandings,
written or oral, with respect to the terms and conditions of your employment. This Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed to in writing by
you and an expressly authorized representative of the Board. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content of any provision
of this Agreement. This Agreement may be executed in two or more counterparts, each of which shall be an original and all of which together shall constitute one and the same instrument. This is a
Massachusetts contract and shall be governed and construed in accordance with the laws of the Commonwealth of Massachusetts, without regard to the conflict-of-laws principles
thereof. 

        12.    Notices.    Any notices provided for in this Agreement shall be in writing and shall be
effective when delivered in person, consigned to a reputable national courier service for overnight delivery or deposited in the United States mail, postage prepaid, and addressed to you at your last
known address on the books of the Company or, in the case of the Company, to it by notice to the Chairman of the Board of Directors, c/o Sirtris Pharmaceuticals, Inc. at its principal place of
business, or to such other address(es) as either party may specify by notice to the other actually received. 

        If
the foregoing is acceptable to you, please sign and date this letter in the spaces provided. At the time you sign and return it, this letter will take effect as a binding agreement
between you and the Company on the basis set forth above. The enclosed copy is for your records. 

Sincerely,

Sirtris Pharmaceuticals, Inc. 

	By:	/s/  CHRISTOPH WESTPHAL      
 Christoph Westphal

President and Chief Executive Officer	 
	

Accepted and Agreed:
	

Signature:
	

 	

/s/  PETER ELLIOTT      
 Peter Elliott	

 

Date:
August 16, 2005 

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Exhibit 10.14    
    

AGREEMENT  

        AGREEMENT made and entered into in Cambridge, Massachusetts, by and between Sirtris Pharmaceuticals, Inc. (the "Company"), a Massachusetts corporation with
its principal place of business at Cambridge, Massachusetts, and Michael Jirousek, of San Diego, California (the "Executive"), effective as of the 30th day of August, 2006. 

        WHEREAS,
the operations of the Company and its Affiliates are a complex matter requiring direction and leadership in a variety of areas, including research and others; 

        WHEREAS,
the Executive is possessed of certain experience and expertise that qualify him to provide the direction and leadership required in these areas by the Company and its
Affiliates; and 

        WHEREAS,
subject to the terms and conditions hereinafter set forth, the Company therefore wishes to employ the Executive as its Senior Vice President, Research and the Executive wishes
to accept such employment; 

        NOW,
THEREFORE, in consideration of the foregoing premises and the mutual promises, terms, provisions and conditions set forth in this Agreement, the parties hereby agree: 

        1.    Employment.    Subject to the terms and conditions set forth in this Agreement, the Company hereby offers, and
the Executive hereby accepts, employment. 

        2.    Term.    The executive shall be employed for an undefined term, commencing on the effective date thereof, and on
an at-will basis. The Executive's rights upon the termination of employment shall be governed by the terms of Section 5 hereof. The period of this agreement is hereafter referred to
as "the term of this Agreement" or "the term hereof." 

        3.    Capacity and Performance.    

        (a)   During
the term hereof, the Executive shall serve the Company as its Senior Vice President, Research, reporting to the Chief Executive Officer of the Company. 

        (b)   During
the term hereof, the Executive shall be employed by the Company on a full-time basis and shall perform the duties and responsibilities of his position
and such other duties and responsibilities on behalf of the Company and its Affiliates, reasonably related to that position, as may be designated from time to time by the Board of Directors of the
Company (the "Board") or by its Chair or other designee. 

        (c)   During
the term hereof, the Executive shall devote his full business time and his best efforts, business judgment, skill and knowledge exclusively to the advancement of
the business and interests of the Company and its Affiliates and to the discharge of his duties and responsibilities hereunder. The Executive shall not engage in any other business activity or serve
in any industry, trade, professional, governmental or academic position during the term of this Agreement, except as may be expressly approved in advance by the CEO in writing. 

        4.    Compensation and Benefits.    As compensation for all services performed by the Executive under and during the
term hereof and subject to performance of the Executive's duties and of the obligations of the Executive to the Company and its Affiliates, pursuant to this Agreement or otherwise: 

        (a)    Base Salary.    During the term hereof, the Company shall pay the Executive a base salary at the rate of Two
Hundred Sixty Thousand Dollars ($260,000.00) per year, payable in accordance with the ordinary payroll practices of the Company for its executives and subject to adjustment 

1

 

from
time to time by the Board after the first year of employment, in its sole discretion. Such base salary, as from time to time adjusted, is hereafter referred to as the "Base Salary". 

        (b)    Incentive and Bonus Compensation.    

        (1)    Signing Bonus.    The Company shall pay the Executive a one-time signing bonus of One Hundred Forty
Thousand Dollars ($140,000.00) within thirty (30) days of the effective date hereof. 

        (2)    Annual Bonus.    The Executive shall be considered annually by the Board for a bonus with a target of 20% of
the Base Salary earned. The amount of the bonus shall be determined by the Board, based on its assessment, in its discretion, of the Executive's performance and that of the Company against appropriate
goals established annually by the Company after consultation with the Executive; which bonus, if any, shall be payable not later than two and one-half months following the end of the
fiscal year for which the bonus was earned. Any bonus or incentive compensation paid to the Executive shall be in addition to the Base Salary. 

        (c)    New Hire Stock Option.    Following the date the Executive commences employment hereunder, the Board of
Directors shall grant to the Executive an option to purchase 900,000 shares of the common stock of the Company at a price to be determined by the Board on the date of the grant (the "New Hire Stock
Option"). The shares that are subject to the New Hire Stock Option shall vest as follows: Twenty-five percent (25%) of the shares subject to the New Hire Stock Option shall vest on the
one-year anniversary of the date of hire, provided that the Executive is still employed by the Company on such date. After the one-year anniversary of the date of hire, the
remaining seventy-five percent (75%) of the shares subject to the New Hire Stock Option shall vest at the rate of 6.25% per quarter on the hire anniversary date of each of the next twelve
(12) quarters after the one-year anniversary date, provided that the Executive is still employed by the Company on such dates. The New Hire Stock Option and any other options
granted to the Executive by the Company shall be subject to any applicable stock option plan, option certificate and shareholder and/or option holder agreements and other restrictions and limitations
generally applicable to equity held by Company executives or otherwise required by law. The Executive shall not be eligible to receive any stock options, restricted stock or other equity of the
Company, however, whether under an equity incentive plan or otherwise, except as expressly provided in this Agreement or as otherwise expressly authorized for him individually by the Board. 

        (d)    Vacations and Holidays.    During the term hereof, the Executive shall be entitled to earn vacation at the rate
of three (3) weeks per year (or such greater amount as is generally made available to the Company's executive officers), to be taken at such times and intervals as shall be mutually agreed by
the Executive and Chief Executive Officer. Vacation shall otherwise be governed by the policies of the Company, as in effect from time to time. In addition, during the term hereof, the Executive shall
be entitled to receive paid holidays (currently 11 per year) in accordance with the Company's holiday schedule. 

        (e)    Other Benefits.    During the term hereof, the Executive shall be entitled to participate in any and all
Employee Benefit Plans from time to time in effect for employees of the Company generally, except to the extent any such Employee Benefit Plan is in a category of benefit otherwise provided to the
Executive (e.g., a severance pay plan). Such participation shall be subject to the terms of the applicable plan documents and generally applicable
Company policies. The Company may alter, modify, add to or cancel its Employee Benefit Plans at any time as it, in its sole judgment, determines to be appropriate, without recourse by the Executive. 

        For
purposes of this Agreement, "Employee Benefit Plan" shall have the meaning ascribed to such term in Section 3(3) of ERISA, as
amended from time to time. 

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        (f)    Business Expenses.    The Company shall pay or reimburse the Executive for all reasonable, customary and
necessary business expenses incurred or paid by the Executive in the performance of his duties and responsibilities hereunder, subject to any maximum annual limit and other restrictions on such
expenses set by the Board and to such reasonable substantiation and documentation as may be specified by the Company from time to time. 

        5.    Termination of Employment and Severance Benefits.    Notwithstanding the provisions of Section 2 hereof,
the Executive's employment hereunder shall terminate prior to the expiration of the term hereof under the following circumstances: 

        (a)    Death.    In the event of the Executive's death during the term hereof, the Executive's employment hereunder
shall immediately and automatically terminate. In such event, the Company shall pay to the Executive's designated beneficiary or, if no beneficiary has been designated by the Executive in writing, to
his estate, (i) any Base Salary earned but not paid during the final payroll period of the Executive's employment through the date of termination, (ii) pay for any vacation time earned
but not used through the date of termination, (iii) any bonus compensation awarded for the fiscal year preceding that in which termination occurs, but unpaid on the date of termination, and
(iv) any business expenses incurred by the Executive but un-reimbursed on the date of termination, provided that such expenses and required substantiation and documentation are
submitted within sixty (60) days of termination and that such expenses are reimbursable under Company policy (all of the foregoing, "Final Compensation"). In addition to Final Compensation, in
the event of the Executive's death during the first four years of the term hereof, up to an additional twenty-five percent (25%) of the Executive's stock options shall vest as of the date
of the Executive's death, provided that no more than one hundred-percent (100%) of the total shares may vest at any time. 

        (b)    Disability.    

        (i)    The
Company may terminate the Executive's employment hereunder, upon notice to the Executive, in the event that the Executive becomes disabled during his employment
hereunder through any illness, injury, accident or condition of either a physical or psychological nature and, as a result, is unable to perform substantially all of his duties and responsibilities
hereunder, notwithstanding the provision of any reasonable accommodation, for one hundred and twenty (120) days during any period of three hundred and sixty-five
(365) consecutive calendar days. In the event of such termination, in addition to Final Compensation and provided that the Company's benefits do not include disability insurance benefits that
will continue the Executive's Base Salary for the period of six (6) months from
the date of termination, the Company shall, for the period of six (6) months from the date of termination, continue to pay the Executive the amount by which 100% of the Executive's Base Salary
exceeds the disability insurance benefits, if any, actually paid to the Executive during that period. In addition, in the event that the Executive's employment hereunder is terminated pursuant to this
Section 5(b) during the first four years of the term hereof, up to an additional twenty-five percent (25%) of the Executive's stock options shall vest as of the date of such
termination, provided that no more than one hundred-percent (100%) of the total shares may vest at any time. 

        (ii)   The
Board may designate another employee to act in the Executive's place during any period of the Executive's disability. Notwithstanding any such designation, the
Executive shall continue to receive the Base Salary in accordance with Section 4(a) and benefits in accordance with Section 4(e), to the extent permitted by the then-current
terms of the applicable benefit plans, until the Executive becomes eligible for disability income benefits under the Company's disability income plan or until the termination of his employment,
whichever shall first occur. 

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        (iii)  While
receiving disability income payments under the Company's disability income plan, the Executive shall not be entitled to receive any Base Salary under
Section 4(a) hereof, but shall continue to participate in Company benefit plans in accordance with Section 4(e) hereof and the terms of such plans, until the termination of his
employment. 

        (iv)  If
any question shall arise as to whether, during any period the Executive is disabled through any illness, injury, accident or condition of either a physical or
psychological nature so as to be unable to perform substantially all of his duties and responsibilities hereunder, the Executive may, and at the request of the Company shall, submit to a medical
examination by a physician selected by the Company to whom the Executive or his duly appointed guardian, if any, has no reasonable objection to determine whether the Executive is so disabled, and such
determination shall for the purposes of this Agreement be conclusive of the issue. If such question shall arise and the Executive shall fail to submit to such medical examination, the Company's
determination of the issue shall be binding on the Executive. 

        (c)    By the Company for Cause.    The Company may terminate the Executive's employment hereunder for Cause at any
time upon notice to the Executive setting forth in reasonable detail the nature of such Cause. The following, as determined by the Board in its reasonable judgment, shall constitute Cause for
termination: 

        (i)    The
Executive's failure to perform (other than by reason of disability), or material negligence in the performance of, his duties and responsibilities to the Company or
any of its Affiliates; 

        (ii)   Material
breach by the Executive of any provision of this Agreement or any other agreement with the Company or any of its Affiliates; or 

        (iii)  Other
conduct by the Executive that is or could be harmful to the business, interests or reputation of the Company or any of its Affiliates. 

Upon
the giving of notice of termination of the Executive's employment hereunder for Cause, the Company shall have no further obligation to the Executive, other than for Final Compensation. 

        (d)    By the Company Other than for Cause.    The Company may terminate the Executive's employment hereunder other
than for Cause at any time upon notice to the Executive. In the event of such termination, in addition to Final Compensation and provided that no benefits are payable to the Executive under a separate
severance agreement as a result of such termination, then until the conclusion of a period of six (6) months following the date of termination, the Company shall continue to pay the Executive
the Base Salary at the rate in effect on the date of termination and, subject to any employee contribution applicable to the Executive on the date of termination, shall continue to contribute to the
premium cost of the Executive's participation in the Company's group medical and dental plans, provided that the Executive is entitled to continue such participation under applicable law and plan
terms and provided that the Company's obligation to contribute to such premium cost shall terminate on the date that the Executive becomes eligible to enroll in the group medical and dental plans of a
new employer if this occurs prior to the end of the six-month period. Any obligation of the Company to the Executive hereunder is conditioned, however, upon the Executive signing and
returning to the Company a timely and effective release of claims in the form provided by the Company (the "Release of Claims"). The Release of Claims required for separation benefits in accordance
with Section 5(d) or Section 5(e) hereof creates legally binding obligations on the part of the Executive, and the Company and its Affiliates therefore advise the Executive to seek the
advice of an attorney before signing it. Base Salary to which the Executive is entitled hereunder shall be payable in accordance with the normal payroll practices of the Company, and will begin at the
Company's next regular payroll period which is at least five business days following the later of the effective date of the Release of 

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Claims
or the date the Release of Claims, signed by the Executive, is received by the Company, but the first payment shall be retroactive to next business day following the date of termination. 

        (e)    By the Executive for Good Reason.    The Executive may terminate his employment hereunder for Good Reason, upon
notice to the Company setting forth in reasonable detail the nature of such Good Reason. The following shall constitute Good Reason for termination by the Executive: 

        (i)    Removal
of the Executive, without his consent, from the position of Senior Vice President, Research of the Company (or a successor corporation) or such other executive
position to which the Executive may be assigned pursuant to Section 3(a) hereof; 

        (ii)   Material
diminution in the nature or scope of the Executive's responsibilities, duties or authority other than as is materially consistent with the Executive's
assignment to another executive position in accordance with Section 3(a) hereof, provided the Executive shall have given the Company no less than 15 days' written notice of such claimed
material diminution and a reasonable opportunity to cure the same. Provided further, a change in reporting relationships resulting from the direct or indirect control of the Company (or a successor
corporation) by another corporation, and any diminution of the business of the Company or any of its Affiliates, and/or any sale or transfer of equity, property or other assets of the Company or any
of its Affiliates shall not constitute "Good Reason"; or 

        (iii)  Material
failure of the Company to provide the Executive the Base Salary and benefits in accordance with the terms of Section 4 hereof, excluding an inadvertent
failure which is cured within 15 business days following notice from the Executive specifying in detail the nature of such failure. 

In
the event of termination in accordance with this Section 5(e), and provided that no benefits are payable to the Executive under a separate severance agreement as a result of such
termination, then the Executive will be entitled to the same pay and benefits he would have been entitled to receive had the Executive been terminated by the Company other than for Cause in accordance
with Section 5(d) above; provided that the Executive satisfies all conditions to such entitlement, including without limitation the signing of an effective Release of Claims. 

        (f)    By the Executive Other than for Good Reason.    The Executive may terminate his employment hereunder at any
time upon sixty (60) days' notice to the Company, unless such termination would violate any obligation of the Executive to the Company under a separate severance agreement. In the event of
termination of employment by the Executive pursuant to this Section 5(f), the Board may elect to waive the period of notice, or any portion thereof, and, if the Board so elects, the Company
will pay the Executive his Base Salary for the initial sixty (60) days of the notice period (or for any remaining portion of such period). The Company shall have no further obligation to the
Executive, other than for any Final Compensation due to him. 

        (g)    Timing of Payments.    If at the time of the Executive's separation from service, the Executive is a "specified
employee," as hereinafter defined, any and all amounts payable under this Section 5 in connection with such separation from service that constitute deferred compensation subject to
Section 409A of the Internal Revenue Code of 1986, as amended, ("Section 409A"), as determined by the Company in its sole discretion, and that would (but for this sentence) be payable
within six months following such separation from service, shall instead be paid at the later of the time otherwise provided in Section 5 or the time that will prevent such amounts from being
considered deferred compensation. For purposes of the preceding sentence, "separation from service" shall be determined in a manner consistent with subsection (a)(2)(A)(i) of
Section 409A and the term "specified employee" shall mean an individual determined by the Company to be a specified employee as defined in subsection (a)(2)(B)(i) of Section 409A. 

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        (h)    Post-Agreement Employment.    In the event the Executive remains in the employ of the Company or
any of its Affiliates following termination of this Agreement, by the expiration of the term or otherwise, then such employment shall be at will. 

        6.    Effect of Termination.    The provisions of this Section 6 shall apply to any termination, whether due to
the expiration of the term hereof, pursuant to Section 5 or otherwise. 

        (a)   Payment
by the Company of any Base Salary, contributions to the cost of the Executive's continued participation in the Company's group health and dental plans and
additional vesting of shares of the New Hire Stock Option that may be due the Executive, in each case under the applicable termination provision of Section 5, shall constitute the entire
obligation of the Company to the Executive. The Executive shall promptly give the Company notice of all facts necessary for the Company to determine the amount and duration of its obligations in
connection with any termination pursuant to Section 5(d) or 5(e) hereof. 

        (b)   Except
for any right of the Executive to continue medical and dental plan participation in accordance with applicable law, benefits shall terminate pursuant to the terms
of the applicable benefit plans based on the date of termination of the Executive's employment without regard to any continuation of Base Salary or other payment to the Executive following such date
of termination. 

        (c)   Provisions
of this Agreement shall survive any termination if so provided herein or if necessary or desirable to accomplish the purposes of other surviving provisions,
including without limitation the obligations of the Executive under Section 7 hereof. The obligation of the Company to make payments to or on behalf of the Executive under Section 5(e)
or 5(f) hereof is expressly conditioned upon the Executive's continued full performance of his obligations under Section 7 hereof. The Executive recognizes that, except as expressly provided in
Section 5(d) or 5(e), no compensation is earned after termination of employment. 

        7.    Confidential Information, Non-Competition and Proprietary Information.    The Executive acknowledges
that his employment with the Company is conditioned upon and subject to his agreement to the Company's Confidentiality, Non-Competition and Proprietary Information Agreement, to be
executed by the Executive simultaneously herewith. The Executive understands and agrees that any breach by him of the Confidentiality, Non-Competition and Proprietary Information Agreement
shall constitute a material breach of this Agreement. 

        8.    Conflicting Agreements.    The Executive hereby represents and warrants that the execution of this Agreement and
the performance of his obligations hereunder will not breach or be in conflict with any other agreement to which the Executive is a party or is bound, and that the Executive is not now subject to any
covenants against competition or similar covenants or any court order or other legal obligation that would affect the performance of his obligations hereunder. The Executive will not disclose to or
use on behalf of the Company any proprietary information of a third party without such party's consent. 

        9.    Definitions.    Words or phrases which are initially capitalized or are within quotation marks shall have the
meanings provided in this Section and as provided elsewhere herein. For purposes of this Agreement, the following definitions apply: 

        (a)   "Affiliates"
means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by either
management authority, contract or equity interest. 

        (b)   "Person"
means an individual, a corporation, a limited liability company, an association, a partnership, an estate, a trust and any other entity or organization, other
than the Company or any of its Affiliates. 

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        10.    Withholding.    All payments made by the Company under this Agreement shall be reduced by any tax or other
amounts required to be withheld by the Company under applicable law. 

        11.    Assignment.    Neither the Company nor the Executive may make any assignment of this Agreement or any interest
herein, by operation of law or otherwise, without the prior written consent of the other; provided, however, the Company may assign its rights and obligations under this Agreement without the consent
of the Executive in the event that the Executive is transferred to a position with any of the Affiliates or in the event that the Company shall hereafter effect a reorganization, consolidate with, or
merge into, any Person or transfer all or substantially all of its properties or assets to any Person. This Agreement shall inure to the benefit of and be binding upon the Company and the Executive,
their respective successors, executors, administrators, heirs and permitted assigns. 

        12.    Severability.    If any portion or provision of this Agreement shall to any extent be declared illegal or
unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so
declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

        13.    Waiver.    No waiver of any provision hereof shall be effective unless made in writing and signed by the
waiving party. The failure of either party to require the performance of any term or obligation of this Agreement, or the waiver by either party of any breach of this Agreement, shall not prevent any
subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach. 

        14.    Notices.    Any and all notices, requests, demands and other communications provided for by this Agreement
shall be in writing and shall be effective when delivered in person, consigned to a reputable national courier service or deposited in the United States mail, postage prepaid, registered or certified,
and addressed to the Executive at his last known address on the books of the Company or, in the case of the Company, at its principal place of business, attention of Chairman of the Board of
Directors, or to such other address as either party may specify by notice to the other actually received. 

        15.    Entire Agreement.    This Agreement, together with the Confidentiality, Non-Competition and
Proprietary Information Agreement, constitutes the entire agreement between the parties and supersedes all prior communications, agreements and understandings, written or oral, with respect to the
terms and conditions of the Executive's employment. 

        16.    Amendment.    This Agreement may be amended or modified only by a written instrument signed by the Executive
and by an expressly authorized representative of the Company. 

        17.    Arbitration.    

        (a)   Any
dispute, controversy or claim between the parties arising out of this Agreement shall be settled by arbitration conducted in Cambridge, Massachusetts in accordance
with the American Arbitration Association National Rules for the Resolution of Employment Disputes (the "Rules") and the laws of the Commonwealth of Massachusetts. 

        (b)   In
the event that a party requests arbitration (the "Requesting Party"), it shall serve upon the other party (the "Non-Requesting Party"), within ninety
(90) days of the date the Requesting Party knew, or reasonably should have known, of the facts on which the controversy, dispute or claim is based, a written demand for arbitration stating the
substance of the controversy, dispute or claim, the contention of the party requesting arbitration and the name and address of the arbitrator appointed by it. The Non-Requesting Party,
within twenty (20) days of such demand, shall accept the arbitrator or appoint a second arbitrator and notify the other party of the name and address of this second arbitrator so selected, in
which case the two arbitrators shall appoint a 

7

 

neutral
umpire. Upon the appointment of such neutral umpire, each of the two partisan arbitrators appointed by the parties shall withdraw from the case, and the neutral umpire shall preside over the
matter as sole decisionmaker. In the event that the two partisan arbitrators fail in any instance to appoint a third arbitrator within twenty (20) days of the appointment of the second
arbitrator, either arbitrator or any party to the arbitration may apply to the American Arbitration Association for appointment of the neutral umpire in accordance with the Rules. Should the
Non-Requesting Party (upon whom a demand for arbitration has been served) fail or refuse to accept the arbitrator appointed by the other party or to appoint an arbitrator within twenty
(20) days, the single arbitrator shall have the right to decide alone, and such arbitrator's decision or award shall be final and binding upon the parties. 

        (c)   The
function of the arbitrator shall be to determine the interpretation and application of the specific provisions of this Agreement to the issues submitted to
arbitration. There shall be no right in arbitration to obtain, and no arbitrator shall have any authority to award or determine, any change in, addition to, or detraction from, any of the provisions
of this Agreement. The decision of the arbitrator shall be in writing; shall set forth the basis for the decision; and shall be rendered within thirty (30) business days following the hearing.
The decision of the arbitrator acting within the scope of his/her authority shall be final and binding upon the parties and may be enforced and executed upon in any court having jurisdiction over the
party against whom enforcement of such award is sought. 

        (d)   The
parties involved in the dispute shall divide equally the administrative charges, arbitrator's fees and related expenses of the arbitration, but each party shall pay
its own legal fees incurred in connection with such arbitration. 

        (e)   Nothing
contained herein, however, shall limit the right of the Company to seek equitable or other relief from any court of competent jurisdiction for violation of the
Confidentiality, Non-Competition and Proprietary Information Agreement. 

        18.    Headings.    The headings and captions in this Agreement are for convenience only and in no way define or
describe the scope or content of any provision of this Agreement. 

        19.    Counterparts.    This Agreement may be executed in two or more counterparts, each of which shall be an original
and all of which together shall constitute one and the same instrument. 

        20.    Governing Law.    This is a Massachusetts contract and shall be construed and enforced under and be governed in
all respects by the laws of the Commonwealth of Massachusetts, without regard to the conflict of laws principles thereof. 

        IN
WITNESS WHEREOF, this Agreement has been executed as a sealed instrument by the Company, by its duly authorized representative, and by the Executive, as of the date first above
written. 

	THE EXECUTIVE:	 	 	 	THE COMPANY
	    	 	 	 	 
	    	 	 	 	 
	    	 	 	 	 
	/s/ MICHAEL JIROUSEK
 Michael Jirousek	 	By:	 	/s/ CHRISTOPH WESTPHAL

	 	 	Title:	 	Chief Executive Officer

8

QuickLinks

Exhibit 10.14

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