Document:

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                                                                  EXHIBIT 10.24c

                          SECOND AMENDMENT TO SUBLEASE

THIS SECOND AMENDMENT TO SUBLEASE ("Second Amendment") is made as of June 1,
2004 by and between Sorrento Montana, LP., a California Limited Partnership
("Landlord") and Integra NeuroSciences CA Corporation, a Delaware Corporation
("Tenant"), with reference to the following facts and circumstances:

            A. Landlord and Camino NeuroCare, Inc. entered into a Sublease dated
            July 1, 2001 ("Sublease") for approximately 16,205 square feet of
            premises commonly known as Suites #706 through #714 and Suite #716,
            5965 Pacific Center Boulevard, San Diego, California 92121
            ("Premises").

            B. Landlord and Tenant subsequently amended and supplemented the
            Sublease through First Amendment to Sublease dated July 1, 2003
            which in part substituted Integra Neurosciences CA Corporation for
            Camino NeuroCare, Inc. as Tenant and extended the term of the
            Sublease two additional years through June 30, 2005.

Landlord and Tenant desire to modify, amend and supplement the Sublease through
this Second Amendment as follows:

            1. Paragraph 1.4 ("PREMISES") is hereby amended to add the
            approximately 1,180 square foot Suite #717, 5965 Pacific Center
            Boulevard, San Diego, California 92121 to Tenant's Premises in an
            "as is" condition effective June 1, 2004 resulting in Premises of
            approximately 17,385 square feet.

            2. Paragraph 1.8 ("INITIAL SECURITY DEPOSIT") is hereby amended to
            provide for Tenant's Security Deposit to be Increased by One
            Thousand One Hundred Twenty-One and No/100 Dollars ($1,121.00),
            resulting in a Security Deposit of Sixteen Thousand Five Hundred
            Fifteen and 75/100 Dollars ($16,515.75).

            3. Paragraph 1.9.1 ("BASE RENT") is amended to provide for payment
            by Tenant of Base Rent of Sixteen Thousand Five Hundred Fifteen and
            75/100 Dollars ($16,515.75) per month effective June 1, 2004.

            4. Paragraph 17.0 ("OPTION TO RETURN PREMISES") is hereby deleted in
            its entirety.

                        Except as specifically provided in this Second
Amendment, all of the terms, conditions and definitions set forth in the
Sublease shall remain unchanged and in full force and effect. In the event of
any conflict between this Second Amendment and the Sublease, the terms of this
Second Amendment shall prevail.

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IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment To
Sublease effective the day and year first written above:

LANDLORD:                                                TENANT:

SORRENTO MONTANA, L.P.                           INTEGRA NEUROSCIENCES CA
                                                 CORPORATION
                                                 A Delaware Corporation

A California Limited Partnership
By:  Sorrento Commercial Properties, Inc.        By: /s/ Stuart M. Essig
A California Corporation doing business as       -----------------------
Sorrento Management Company                      Title: President and CEO

                                                 Date: 5/11/04
By: /s/ Roger W. Hillbrook
    -------------------------------
    Roger W. Hillbrook
    Vice President/Corporate Broker

Date: 5/12/04

                                     Page 2<PAGE>

                                                                  EXHIBIT 10.24d

                           THIRD AMENDMENT TO SUBLEASE

THIS THIRD AMENDMENT TO SUBLEASE ("Third Amendment") is made as of June 15, 2004
by and between Sorrento Montana, L.P., a California Limited Partnership
("Landlord") and Integra LifeSciences Corporation, successor by merger to
Integra NeuroSciences CA Corporation, a Delaware Corporation ("Tenant"), with
reference to the following facts and circumstances:

      I.    Landlord and Camino NeuroCare, Inc. entered into a Sublease dated
            July 1, 2001 for approximately 16,205 square feet of premises
            commonly known as Suites #706 through #714 and Suite #7l6, 5965
            Pacific Center Boulevard, San Diego, California 92121 ("Premises").

      II.   Landlord and Tenant subsequently modified and amended the Sublease
            through First Amendment to Sublease dated July 1, 2003. which in
            part extended the term of the Sublease two additional years through
            June 30, 2005 and granted Tenant one Option to Renew the Sublease
            for an additional two-year term through June 30, 2007.

      III.  Landlord and Tenant subsequently modified and amended the Sublease
            through Second Amendment to Sublease dated June 1, 2004, which in
            part added the approximately 1,180 square foot Suite #717 to
            Tenant's Sublease effective June 1, 2004.

Landlord and Tenant desire to further modify, amend and supplement the Sublease
through this Third Amendment as follows:

      1.    Tenant hereby exercises it Option to Renew contained in First
            Amendment to Sublease, and Paragraph 15 ("SUBLEASE TERM") is
            therefore and hereby amended to extend the term of the Sublease an
            additional twenty-four months through June 30, 2007.

      2.    Paragraph 14.0 ("OPTION TO REVIEW') is hereby amended to provide
            Tenant with an Option to Renew ("Option") this Sublease for one
            additional two-year term commencing July l, 2007 and continuing for
            twenty-four consecutive months. Provided Tenant is not in default of
            this Sublease or Tenant's July 1, 2001 Sublease of 5955 Pacific
            Center Boulevard as subsequently amended, Tenant shall exercise the
            Option by notifying Landlord in writing on or before December 31,
            2006 of Tenant's intention to renew. Tenant's Beginning Base Rent
            for the option term shall be one hundred four percent (104%) of the
            Base Rent payable by Tenant for the month of June 2007. Tenant's
            failure to exercise the Option on or before December 31, 2006 shall
            constitute a waiver of the Option by Tenant.

      3.    Paragraph 18.0 ("RIGHT OF FIRST REFUSAL") is hereby added, which,
            provided Tenant is not in default of this Sublease or Tenant's July
            1, 2001 Sublease of 5955 Pacific Center Boulevard as subsequently
            amended, shall provide Tenant with a one-time Right of First Refusal
            ("Right") to individually add each of the following suites within
            5965 Pacific Center Boulevard ("Additional Premises") to Tenant's
            Sublease as the suites are vacated by the present occupants or
            otherwise

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            become available from time to time during the term of Tenant's
            Sublease and any extensions thereof:

                  Suite #701 (approximately 781 square feet) Suites #702 through
                  #705 (approximately 4,956 square feet) Suite #715
                  (approximately 1,027 square feet)

            Upon receipt and conditional acceptance by Landlord of a bona fide
            offer or offers from an outside thud party or parties ("Third
            Party") to sublease any or all of the Additional Premises spaces
            listed above, Landlord shall promptly notify Tenant of the terms and
            conditions upon which Landlord is willing to sublease the Particular
            Additional Premises space to the Third Party. Tenant shall have ten
            (10) working days from receipt of Landlord's notice within which to
            agree in writing to add the Additional Premises to Tenant's Sublease
            upon the same terms and conditions as offered by the Third Party and
            conditionally accepted by Landlord. In the event Tenant rejects or
            fails to respond to Landlord within ten (10) working days of receipt
            of Landlord's notice. Tenant's Right of First Refusal as pertains to
            the particular space involved shall become null and void, and
            Landlord shall have no further obligation with regard thereto.

            Except as specifically provided in this Third Amendment, all of the
terms, conditions and definitions set faith in the Sublease shall remain
unchanged and in full force and effect. In the event of any conflict between
this Third Amendment and the Sublease, the terms of this Third Amendment shall
prevail.

IN WITNESS WHEREOF, the parties hereto have executed this Third Amendment To
Sublease effective the day and year first written above:

LANDLORD:                                                 TENANT:

SORRENTO MONTANA, L.P., A                           INTEGRA LIFESCIENCES
                                                    CORPORATION
                                                    A Delaware Corporation

A California Limited Partnership
By:  Sorrento Commercial Properties, Inc.           By: /s/ Stuart M. Essig
A California Corporation doing business as          -----------------------
Sorrento Management Company                         Title: CEO

                                                    Date:  7/15/04
By: /s/ Roger W. Hillbrook
    -------------------------------
    Roger W. Hillbrook
    Vice President/Corporate Broker

Date: 7/19/04

                                     Page 2<PAGE>

                                                                   EXHIBIT 10.30

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                        STOCK OPTION GRANT AND AGREEMENT
                                   Pursuant to
                           2003 EQUITY INCENTIVE PLAN

      STOCK OPTION GRANT AND AGREEMENT made as of the 27th day of July, 2004
(the "Grant Date"), between INTEGRA LIFESCIENCES HOLDINGS CORPORATION, a
Delaware corporation (the "Company"), and STUART M. ESSIG, an employee of the
Company (the "Employee").

      WHEREAS, the Company desires to afford the Employee an opportunity to
purchase shares of common stock of the Company ("Common Stock"), par value $.01
per share, as hereinafter provided, under the Integra LifeSciences Holdings
Corporation 2003 Equity Incentive Plan (the "2003 Plan"), a copy of which is
attached.

      NOW THEREFORE, in consideration of the mutual covenants hereinafter set
forth and for other good and valuable consideration the legal sufficiency of
which is hereby acknowledged, the parties hereto, intending to be legally bound
hereby, agree as follows:

            1. Grant of Option. Pursuant to Section 3.2(b)(i)(B) of the Amended
and Restated Employment Agreement by and between the Employee and the Company
dated as of July 27, 2004 (the "Employment Agreement"), the Company hereby
grants to the Employee a non-qualified stock option (the "Option") to purchase
all or any part of an aggregate of 250,000 shares of Common Stock.

            2. Purchase Price. The purchase price per share of the shares of
Common Stock covered by the Option shall be $31.38. It is the determination of
the Company's Stock Option Committee (the "Committee") that on the Grant Date
the purchase price per share was not less than the greater of one hundred
percent (100%) of the fair market value of the Common Stock, or the par value
thereof.

            3. Term. Unless earlier terminated pursuant to any provision of this
Stock Option Grant and Agreement or the Employment Agreement, this Option shall
expire on July, 27, 2014 (the "Expiration Date"), which date is not more than
ten (10) years from the Grant Date. Notwithstanding anything herein to the
contrary, this Option shall not be exercisable after the Expiration Date.

            4. Exercise of Option. The Committee, using its authority and
discretion under Sections 3(b) and 7.1 of the 2003 Plan to set the terms of
Options granted under the 2003 Plan, has determined that this Option, subject to
law and regulation, shall vest and become exercisable in such installments and
on such dates, as follows:

            This Option shall vest and become exercisable with respect to 62,500
shares on the first anniversary of the date hereof. Thereafter, this Option
shall vest and become exercisable with respect to 1/36th of the remaining shares
on the first business day of each following month. Except as provided in

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Section 8(i) hereof, this Option shall vest and become exercisable in its
entirety, and shall remain exercisable until the Expiration Date, (i) upon the
occurrence of a "Change in Control" (as defined in the Employment Agreement), or
(ii) upon the receipt of a bona fide two-tier tender offer with respect to the
outstanding shares of Common Stock.

            Once the Option becomes exercisable in accordance with the
foregoing, it shall remain exercisable, subject to the provisions contained in
this Stock Option Grant and Agreement, until the expiration of the term of this
Option as set forth in Paragraph 3 or until other termination of the Option as
set forth in this Stock Option Grant and Agreement.

            5. Method of Exercising Option. Subject to the terms and conditions
of this Stock Option Grant and Agreement, the Option may be exercised in whole
or in part by written notice to the Company, at its principal office, which is
located at 311 Enterprise Drive, Plainsboro, New Jersey 08536. Such notice shall
state the election to exercise the Option, and the number of shares with respect
to which it is being exercised, shall be signed by the person or persons so
exercising the Option; shall, unless the Company otherwise notifies the
Employee, be accompanied by the investment certificate referred to in Section 6;
and shall be accompanied by payment of the full Option price of such shares.

            The Option price shall be paid to the Company in: (i) cash; (ii)
cash equivalent; (iii) Common Stock of the Company, in accordance with Section
7.1(f)(ii) of the 2003 Plan (as in effect on the date of this Stock Option Grant
and Agreement); (iv) any combination of (i)-(iii); or (v) by delivering a
properly executed notice of exercise of the Option in accordance with Section
7.1(f)(iii) of the 2003 Plan (as in effect on the date of this Stock Option
Grant and Agreement).

            Upon receipt of such notice and payment, the Company, as promptly as
practicable, shall deliver or cause to be delivered a certificate or
certificates representing the shares with respect to which the Option is so
exercised. Such certificate(s) shall be registered in the name of the person or
persons so exercising the Option (or, if the Option is exercised by the Employee
and if the Employee so requests in the notice exercising the Option, shall be
registered in the name of the Employee and the Employee's spouse, jointly, with
right of survivorship) and shall be delivered as provided above to or upon the
written order of the person or persons exercising the Option. In the event the
Option is exercised by any person or persons after the legal disability or death
of the Employee, such notice shall be accompanied by appropriate proof of the
right of such person or persons to exercise the Option. All shares that are
purchased upon the exercise of the Option as provided herein shall be fully paid
and not assessable by the Company.

            6. Shares to be Purchased for Investment. Unless the Company has
theretofore notified the Employee that a registration statement covering the
shares to be acquired upon the exercise of the Option has become effective under
the Securities Act of 1933 and the Company has not thereafter notified the
Employee that such registration statement is no longer effective, it shall be a
condition to any exercise of this Option that the shares acquired upon such
exercise be acquired for investment and not with a view to distribution, and the
person effecting such exercise shall submit to the Company a certificate of such
investment intent, together with such other evidence supporting the same as the
Company may request. Notwithstanding the foregoing, upon the written request of

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Employee, the Company shall provide the Employee with a shelf registration
pursuant to a registration statement subject to the terms set forth in Exhibit B
to the Employment Agreement. The Company shall be entitled to delay the
transferability of the shares issued upon any such exercise to the extent
necessary to avoid a risk of violation of the Securities Act of 1933 (or of any
rules or regulations promulgated thereunder) or of any state laws or
regulations. Such restrictions may, at the option of the Company, be noted or
set forth in full on the share certificates. If any law or regulation requires
the Company to take any additional action regarding the Common Stock before the
Company issues certificates for the Common Stock subject to this Option or
before such Common Stock may be transferred by the Employee, the Company shall
use its commercially reasonable best efforts to resolve such problem.

            7. Transferability. This Option is not assignable or transferable,
in whole or in part, by the Employee other than by will or by the laws of
descent and distribution, and during the lifetime of the Employee the Option
shall be exercisable only by the Employee or by his/her guardian or legal
representative.

            8. Termination of Employment. If the Employee's employment with the
Company and all Related Corporations, as defined in the 2003 Plan, is terminated
for any reason other than death or disability prior to the Expiration Date of
this Option as set forth in Paragraph 3, this Option shall vest and become
exercisable in the following manner:

            (i) Termination for Cause or Voluntary Termination Without Good
Reason. If the Employee is terminated for "Cause" as defined in Section 4.3 of
the Employment Agreement, or if the Employee voluntarily leaves his employment
with the Company (other than for "Good Reason" as defined in Section 4.4 of the
Employment Agreement, or "Disability" as defined in Section 4.2 of the
Employment Agreement) prior to December 31, 2009, then the portion of this
Option that is vested on the date of termination shall be exercisable until the
Expiration Date and the non-vested portion of this Option shall terminate on the
date of termination.

            (ii) Termination without Cause or by Employee for Good Reason. If
Employee is terminated without "Cause" or terminates employment for "Good
Reason," then this Option shall become immediately vested and exercisable and
shall remain exercisable in full until the Expiration Date.

            (iii) Termination After December 31, 2009. If the Employee's
employment terminates for any reason following December 31, 2009 (including if
the Employment Agreement is not renewed following December 31, 2009), then this
Option shall remain exercisable in full until the Expiration Date.

            9. Disability. If the Employee is terminated for Disability during
his employment and prior to the Expiration Date of this Option as set forth in
Section 3, the vested portion of this Option shall be exercisable until the
later of (i) one year from the date of termination or (ii) December 31, 2009,
but in no event beyond the Expiration Date, and the non-vested portion of this
Option shall terminate on the date of termination.

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            10. Death. If the Employee dies during his employment and prior to
the Expiration Date, or if the Employee dies during any period following
termination of employment but while this Option is still exercisable, then the
vested portion of this Option shall be exercisable by the Employee's estate,
personal representative or beneficiary who acquired the right to exercise this
Option by bequest or inheritance or by reason of the Employee's death at any
time prior to the later of (i) December 31, 2009, or (ii) one (1) year after the
Employee's death, but in no event beyond the Expiration Date, and the non-vested
portion of this Option shall terminate on the date of Employee's death.

            11. Withholding of Taxes. The obligation of the Company to deliver
shares of Common Stock upon the exercise of the Option shall be subject to
applicable federal, state and local tax withholding requirements. If the
exercise of any Option is subject to the withholding requirements of applicable
federal, state or local tax laws, the Committee, in its discretion, may permit
the Employee, subject to the provisions of the 2003 Plan (as in effect on the
date of this Stock Option Grant and Agreement) and such additional withholding
rules (the "Withholding Rules") as shall be adopted by the Committee, to satisfy
the withholding tax, in whole or in part, by electing to have the Company
withhold (or by returning to the Company) shares of Common Stock, which shares
shall be valued, for this purpose, at their fair market value on the date of
exercise of the Option (or, if later, the date on which the Employee recognizes
ordinary income with respect to such exercise). An election to use shares of
Common Stock to satisfy tax withholding requirements must be made in compliance
with and subject to the Withholding Rules. The Committee may not withhold shares
in excess of the number necessary to satisfy the minimum tax withholding
requirements.

            12. Adjustment of and Changes in the Common Stock.

            (a) In the event the outstanding shares of the Common Stock shall be
changed into an increased number of shares, through a share dividend or a
split-up of shares, or into a decreased number of shares, through a combination
of shares, then immediately after the record date for such change, the number of
shares of Common Stock then subject to the Option shall be proportionately
increased, in case of such share dividend or split-up of shares, or
proportionately decreased, in case of such combination of shares. In the event
the Company shall issue any of its shares of Common Stock or other securities or
property (other than common stock which is covered by the preceding sentence),
in a reclassification of the Common Stock (including without limitation any such
reclassification in connection with a consolidation or merger in which the
Company is the continuing entity), the Option shall be adjusted so that the
Employee shall be entitled to receive upon exercise of the Option the same kind
and number of shares or other securities or property which the Employee would
have owned or have been entitled to receive after the happening of any of the
events described above, had he owned the shares of the Common Stock subject to
the Option immediately prior to the happening of such event or any record date
with respect thereto, which adjustment shall become effective immediately after
the effective date of such event retroactive to the record date, if any, for
such event.

            (b) In the event the Company shall distribute to all holders of the
Common Stock evidences of its indebtedness or assets (including leveraged
recapitalizations with special cash distributions), but excluding regular

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quarterly cash dividends, then in each case the number of shares of Common Stock
thereafter subject to the Option shall be determined by multiplying the number
of shares theretofore subject to the Option by a fraction, (i) the numerator of
which shall be the then current market price per share of Common Stock (as
determined in paragraph (c) below) on the record date for such distribution, and
(ii) the denominator of which shall be the then current market price per share
of the Common Stock less the then fair value (as mutually determined in good
faith by the Board of Directors of the Company (the "Board") and the Employee)
of the portion of the assets or evidences of indebtedness so distributed
applicable to a share of Common Stock. Such adjustment shall be made whenever
any such distribution is made, and shall become effective on the date of
distribution retroactive to the record date for the determination of
shareholders entitled to receive such distribution.

            (c) For the purpose of any computation under paragraph (b) of this
Section 12, the current market price per share of the Common Stock at any date
shall be deemed to be the average of the daily Stock Prices for 15 consecutive
Trading Days commencing 20 Trading Days before the date of such computation.
"Stock Price" for each Trading Day shall be the "Fair Market Value" of the
Common Stock (as defined in the 2003 Plan, as in effect on the date of this
Stock Option Grant and Agreement) for such Trading Day. "Trading Day" shall be
each Monday, Tuesday, Wednesday, Thursday and Friday, other than any day on
which the Common Stock is not traded on the exchange or in the market which is
the principal United States market for the Common Stock.

            (d) Notwithstanding anything in this Agreement to the contrary, in
the event of a spin-off by the Company to its shareholders, the adjustment of
the Option shall be determined in an appropriate and equitable manner, and it is
the intention of the parties hereto that, to the extent practicable, such
adjustment shall include an option grant to acquire an equity interest in the
spun-off entity.

            (e) Whenever the number of shares of Common Stock subject to the
Option is adjusted as herein provided, the purchase price per share of Common
Stock issuable thereunder shall be adjusted by multiplying such purchase price
immediately prior to such adjustment by a fraction, the numerator of which shall
be the number of shares of Common Stock subject to the Option immediately prior
to such adjustment, and the denominator of which shall be the number of shares
of Common Stock subject to the Option immediately thereafter.

            (f) For the purpose of this Section 12, the term "Common Stock"
shall mean (i) the class of Company securities designated as the Common Stock at
the date of this Stock Option and Grant Agreement, or (ii) any other class of
equity interest resulting from successive changes or reclassifications of such
shares consisting solely of changes in par value, or from par value to no par
value, or from no par value to par value. In the event that at any time, as a
result of an adjustment made pursuant to the second sentence of Section 12(a)
above, the Employee shall become entitled to, upon exercise of the Option, any
shares other than the Common Stock, thereafter the number of such other shares
issuable on exercise of the Option and the exercise price per share of Common
Stock issuable thereunder shall be subject to adjustment from time to time in a
manner and on the terms as nearly equivalent as practicable to the provisions
with respect to the shares contained in this Section 12 and the provisions of
this Stock Option and Grant Agreement with respect to the shares of Common Stock
issuable on exercise of the Option shall apply on like terms to any such other
shares.

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            (g) In case of any consolidation of the Company or merger of the
Company with another corporation as a result of which Common Stock is converted
or modified or in case of any sale or conveyance to another corporation of the
property, assets and business of the Company as an entirety or substantially as
an entirety, the Company shall modify the Option so as to provide the Employee
with an option for the kind and amount of shares and other securities and
property that he would have owned or have been entitled to receive immediately
after the happening of such consolidation, merger, sale or conveyance had the
Option, immediately prior to such action, actually been exercised for shares
and, if applicable, other securities of the Company subject to the Option. The
provisions of this Section 12(g) shall similarly apply to successive
consolidations, mergers, sales or conveyances.

            (h) Notwithstanding anything to the contrary contained herein, the
provisions of this Section 12 shall not apply to, and no adjustment is required
to be made in respect of, any of the following: (i) the issuance of shares of
Common Stock upon the exercise of any other rights, options or warrants that
entitle the holder to subscribe for or purchase such shares (it being understood
that the sole adjustment pursuant to this Section 12 in respect of the issuance
of shares of Common Stock upon exercise of rights, options or warrants shall be
made at the time of the issuance by the Company of such rights, options or
warrants, or a change in the terms thereof); (ii) the issuance of shares of
Common Stock to the Company's employees, directors or consultants pursuant to
bona fide benefit plans or employment or consulting arrangements adopted by the
Company's Board of Directors; (iii) the issuance of shares of Common Stock in a
bona fide public offering; (iv) the issuance of shares of Common Stock pursuant
to any dividend reinvestment or similar plan adopted by the Company's Board of
Directors to the extent that the applicable discount from the current market
price for shares issued under such plan does not exceed 5%; and (v) the issuance
of shares of Common Stock in any arm's length transaction (including, without
limitation, any acquisition, financing, private placement, or, except as
provided in Section 12(g), merger or combination or consolidation), directly or
indirectly, to any party.

            (i) In the event the parties hereto cannot agree upon an appropriate
and equitable adjustment to the Option, the services of an independent
investment banker mutually acceptable to Employee and the Company shall (at the
sole expense of the Company) be retained to determine an appropriate and
equitable adjustment, and such determination shall be binding upon the parties.

            (j) For purposes of this Stock Grant and Option Agreement,
"Affiliate" of an entity or individual means any entity or individual, directly
or indirectly, controlling, controlled by or under common control with such
entity or individual.

            13. Legal Fees. If any contest or dispute shall arise between the
Company and the Employee regarding any provisions of this Stock Grant and Option
Agreement, the Company shall reimburse the Employee for legal fees and expenses
reasonably incurred by Employee in connection with such contest or dispute to
the extent set forth in Section 8.1 of the Employment Agreement. The application
of this Section 13 (and Section 8.1 of the Employment Agreement)

                                     Page 6
<PAGE>

shall survive the termination of the Employment Agreement. Such reimbursement
shall be made as soon as practicable following the resolution of such contest or
dispute (whether or not appealed) to the extent the Company receives reasonable
written evidence of such fees and expenses. Notwithstanding any determination or
interpretation by the Committee, any dispute or controversy arising under or in
connection with this Agreement, shall be settled exclusively by arbitration in
Wilmington, Delaware in accordance with the Commercial Arbitration Rules of the
American Arbitration Association then in effect. Judgment may be entered on the
arbitrator's award in any court having jurisdiction.

            14. Construction. Except as would be in conflict with any specific
provision herein, this Stock Option Grant and Agreement is made under and
subject to the provisions of the 2003 Plan as in effect on the Grant Date and,
except as would conflict with the provisions of this Stock Option Grant and
Agreement, all of the provisions of the 2003 Plan as in effect on the Grant Date
are hereby incorporated herein as provisions of this Stock Option Grant and
Agreement. In the event of any such conflict, the terms of this Stock Option
Grant and Agreement shall govern.

            15. Governing Law. This Stock Option Grant and Agreement shall be
governed by applicable federal law and otherwise by the laws of the State of
Delaware.

            16. Amendment or Modification; Waiver. No provision of this
Agreement may be amended, modified or waived unless such amendment or
modification is agreed to in writing, signed by the Employee and by a duly
authorized officer of the Company, and such waiver is set forth in writing and
signed by the party to be charged. No waiver by any party hereto of any breach
by another party hereto of any condition or provision of this Agreement to be
performed by such other party shall be deemed a waiver of a similar or
dissimilar condition or provision at the same time, any prior time or any
subsequent time.

                                     Page 7
<PAGE>

      IN WITNESS WHEREOF, the undersigned have executed this Stock Option Grant
and Agreement as of the date first written above.

                             INTEGRA LIFESCIENCES HOLDINGS CORPORATION

                                     By: /s/ Richard Caruso
                                         --------------------------------------
                                         Richard Caruso, Chairman

                                         /s/ Stuart M. Essig
                                         --------------------------------------
                                         Stuart M. Essig

                                     Page 8

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