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EXHIBIT 4.1

DESCRIPTION OF SECURITIES REGISTERED UNDER
SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934

The following is a summary of the terms and provisions of the common stock, par value $0.001 per share, of Athersys, Inc., a Delaware corporation (“Athersys,” the “Company,” “we”, “us” or “our”), and is qualified in its entirety by reference to the Company’s Certificate of Incorporation and Bylaws, which are incorporated by reference herein and attached as exhibits to the Company’s most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission (the “SEC”), and to applicable provisions of Delaware law. This summary is not complete. You should read the provisions of our Certificate of Incorporation and Bylaws as currently in effect for provisions that may be important to you. 

Authorized Capital Stock

We are authorized to issue 600,000,000 shares of common stock, par value $0.001 per share, and 10,000,000 shares of preferred stock, par value $0.001 per share.

Common Stock

Holders of shares of common stock will be entitled to receive dividends if and when declared by the board of directors from funds legally available therefore, and, upon liquidation, dissolution or winding-up of our company, will be entitled to share ratably in all assets remaining after payment of liabilities. The holders of shares of common stock will not have any preemptive rights, but will be entitled to one vote for each share of common stock held of record. Stockholders will not have the right to cumulate their votes for the election of directors.

Preferred Stock

Our board of directors is authorized, without action by our stockholders, to designate and issue up to 10,000,000 shares of preferred stock, par value $0.001 per share, in one or more series. The board of directors can fix the rights, preferences and privileges of the shares of each series and any of its qualifications, limitations or restrictions. Our board of directors may authorize the issuance of preferred stock with voting or conversion rights that could adversely affect the voting power or other rights of the holders of common stock. The issuance of preferred stock, while providing flexibility in connection with possible future financings, acquisitions and other corporate purposes could, under certain circumstances, have the effect of delaying, deferring or preventing a change in control of us and could adversely affect the market price of our common stock. We do not have any shares of preferred stock outstanding, and we have no current plans to issue any preferred stock.

Transfer Agent and Registrar

We have appointed Computershare Investor Services as the transfer agent and registrar for our common stock.

Listing

Our common stock is listed on the NASDAQ Capital Market under the symbol “ATHX.”Exhibit 10.1

 

NEITHER THIS PROMISSORY NOTE NOR THE SECURITIES ISSUABLE
UPON CONVERSION HEREOF HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAW AND NEITHER
MAY BE SOLD OR OTHERWISE TRANSFERRED UNTIL (i) A REGISTRATION STATEMENT UNDER SUCH SECURITIES ACT AND SUCH APPLICABLE STATE SECURITIES
LAWS SHALL HAVE BECOME EFFECTIVE WITH REGARD THERETO, OR (ii) THE COMPANY SHALL HAVE RECEIVED A WRITTEN OPINION OF COUNSEL ACCEPTABLE
TO THE COMPANY TO THE EFFECT THAT REGISTRATION UNDER SUCH SECURITIES ACT AND SUCH APPLICABLE STATE SECURITIES LAWS IS NOT REQUIRED IN
CONNECTION WITH SUCH PROPOSED TRANSFER.

 

RenovaCare,
Inc.

 

UNSECURED CONVERTIBLE
PROMISSORY NOTE

	$800,000	March 18, 2022
	 	 

For Value Received,
RenovaCare, Inc., a Nevada corporation (the “Borrower”), hereby promises to pay to Kalen
Capital Corporation, a corporation formed and existing under the laws of Alberta, Canada, or its successors or assigns (“Lender”),
the sum of Eight Hundred Thousand Dollars ($800,000), or such lesser amount as shall then equal the outstanding principal amount hereof,
together with any unpaid accrued interest, fees, and charges accrued hereunder as set forth below, on June 30, 2024 (the “Maturity
Date”) in accordance with the terms set forth in this Unsecured Convertible Promissory Note (this “Note”)
and to pay interest on the Outstanding Balance (as defined below) at the rate of one percent (1 %) per annum from the date of this Note
until the Outstanding Balance is paid in full. All interest calculations hereunder shall be computed on the basis of a 360-day year comprised
of twelve (12) thirty (30) day months, shall compound daily and shall be payable in accordance with the terms of this Note.

 

1.        Payment;
Prepayment.

 

1.1Payment. All payments owing hereunder
shall be in lawful money of the United States of America or Conversion Securities (as defined below), as provided for herein, and delivered
to Lender at the address or bank account furnished to Borrower for that purpose. All payments shall be applied first to (a) costs of collection,
if any, then to (b) fees and charges, if any, then to (c) accrued and unpaid interest, and thereafter, to (d) principal.

 

1.2Prepayment. Notwithstanding the
foregoing, Borrower shall have the right to prepay, following written notice to the Lender (the “Prepayment Notice”),
all or any portion of the Outstanding Balance (less such portion of the Outstanding Balance for which Borrower has received a Lender Conversion
Notice (as defined below) prior to the delivery of the Prepayment Notice.

 

1.2.1Prepayment Notice shall be delivered to the
Lender of the Note at its registered addresses and shall state: (1) that the Borrower is exercising its right to prepay the Note, (2)
the amount of the Outstanding Balance to be prepaid (the “Prepayment Amount”) and (2) the date of prepayment
which shall be not more than five (5) Business Days from the date of the Optional Prepayment Notice. On the date fixed for prepayment
(the “Prepayment Date”), the Borrower shall make payment of the Prepayment Amount, or upon the direction of
the Lender as specified by the Lender in a writing to the Borrower (which shall direction to be sent to Borrower by the Lender at least
one (2) Business Day prior to the Prepayment Date)

 

2.       Security.
This Note is unsecured.

 

3.       Conversion
Prior to Maturity Date.

 

3.1Automatic Conversion upon a Qualified
Financing. In the event that Borrower issues and sells shares of its Equity Securities (as defined hereinafter) on or before the
Maturity Date, in an equity financing with total proceeds to the Borrower, from third-parties other than the Lender or any of its Affiliates,
of not less than ten million dollars ($10,000,000) (and excluding the conversion of this Note, and conversion or cancellation of other
indebtedness) (a “Qualified Financing”), then the Outstanding Balance shall automatically convert in whole without
any further action by the Lender into such Equity Securities (as defined below) sold in the Qualified Financing (the “Mandatory
Conversion”) at a conversion price equal to eighty percent (80%) of the price per share paid by the investors purchasing
such Equity Securities in the Qualified Financing (the “Mandatory Conversion Price”). The number of Equity Securities
to be issued and delivered to Lender (the “Mandatory Equity Securities”), on the consummation of a Qualified
Financing, shall be determined as per the following formula: the Outstanding Balance (on the date of the consummation of the Qualified
Financing) divided by the Mandatory Conversion Price. For purposes of this Note, “Equity Securities” shall mean Borrower’s
Common Stock, Preferred Stock (as defined in the Borrower’s Certificate of Incorporation) or any securities (other than debt securities)
conferring the right to purchase Borrower’s Common Stock, Preferred Stock or securities convertible into, or exchangeable for (with
or without additional consideration), Borrower’s Common Stock or Preferred Stock (excluding the Notes), in each case issued in the
Qualified Financing, as the case may be, following the date hereof, except that such defined term shall not include any security granted,
issued and/or sold by Borrower to any employee, director or consultant in such capacity. In connection with the conversion of this Note
into Equity Securities, the Borrower and Lender shall further enter into such other agreements which the Borrower enters into with the
other investors in the Qualified Financing. The Borrower shall deliver the Mandatory Equity Securities to Lender in accordance with the
Qualified Financing’s governing documents.

 

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3.2 Lender’s Optional Conversion.
Notwithstanding Section 3.1, Lender has the right at any time after June 30, 2023 until the Outstanding Balance has been paid in
full, at its election, by delivery to the Borrower of a Lender Conversion Notice (as defined below) to convert (“Lender Optional
Conversion”) all or any portion of the Outstanding Balance into shares of fully paid and non-assessable shares (“Lender
Conversion Shares”) of the Borrower’s common stock, $0.00001 par value per share (“Common Stock”),
of Borrower as per the following conversion formula: the number of Lender Conversion Shares equals the amount being converted (the “Conversion
Amount”) divided by the Conversion Price (as defined below). Conversion notices in the form attached hereto as Exhibit
A (each, a “Lender Conversion Notice”) may be effectively delivered to Borrower by any method set
forth in Section 22 of this Note; the Borrower shall deliver the Lender Conversion Shares from any Lender Optional Conversion to Lender
in accordance with Section 3.3 below.

 

3.2.1Conversion Price. Subject to
adjustment as set forth in this Note, the price at which Lender has the right to convert all or any portion of the Outstanding Balance
into Stock is $0.45 per share, representing a fifty (50%) percent premium to the closing price of the Company’s common stock on
March 17, 2022, the Trading Day immediately preceding the Issuance Date (the “Conversion Price”).

 

3.2.2Adjustment of Conversion Price upon
Subdivision or Combination of Common Stock. Without limiting any provision hereof, if Borrower at any time on or after the date
of this Note subdivides (by any stock split, stock dividend, recapitalization or otherwise) one or more classes of its outstanding Common
Stock into a greater number of shares, the Conversion Price in effect immediately prior to such subdivision will be proportionately reduced.
Without limiting any provision hereof, if Borrower at any time on or after the Effective Date combines (by combination, reverse stock
split or otherwise) one or more classes of its outstanding Common Stock into a smaller number of shares, the Conversion Price in effect
immediately prior to such combination will be proportionately increased. Any adjustment pursuant to this Section 3.2.2 shall become
effective immediately after the effective date of such subdivision or combination. If any event requiring an adjustment under this Section
3.2.2 occurs during the period that a Conversion Price is calculated hereunder, then the calculation of such Conversion Price shall
be adjusted appropriately to reflect such event.

 

3.2.3 Other Events. In the event
that Borrower (or any subsidiary) shall take any action to which the provisions hereof are not strictly applicable, or, if applicable,
would not operate to protect Lender from dilution or if any event occurs of the type contemplated by the provisions of this Section 3.2.3
but not expressly provided for by such provisions (including, without limitation, the granting of stock appreciation rights, phantom stock
rights or other rights with equity features), then Borrower’s board of directors shall in good faith determine and implement an
appropriate adjustment in the Conversion Price so as to protect the rights of Lender, provided that no such adjustment pursuant to this
Section 3.2.3 will increase the Conversion Price as otherwise determined pursuant to this Section 3.2.3, provided further
that if Lender does not accept such adjustments as appropriately protecting its interests hereunder against such dilution, then Borrower’s
board of directors and Lender shall agree, in good faith, upon an independent investment bank of nationally recognized standing to make
such appropriate adjustments, whose determination shall be final and binding and whose fees and expenses shall be borne by Borrower.

 

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3.3Method of Lender Optional Conversion Share
Delivery. On or before the close of business on the fifth (5th) Trading Day following the date of delivery of a Lender
Conversion Notice (the “Delivery Date”), Borrower shall, provided it is DWAC Eligible at such time and such Conversion
Shares are eligible for delivery via DWAC, deliver or cause its transfer agent to deliver the applicable Conversion Shares electronically
via DWAC to the account designated by Lender in the applicable Lender Conversion Notice. If Borrower is not DWAC Eligible or such Conversion
Shares are not eligible for delivery via DWAC, it shall deliver to Lender or its broker (as designated in the Lender Conversion Notice),
via reputable overnight courier, a certificate representing the number of Lender Conversion Shares equal to the number of Lender Conversion
Shares to which Lender shall be entitled, registered in the name of Lender or its designee. For the avoidance of doubt, Borrower has not
met its obligation to deliver the Lender Conversion Shares by the Delivery Date unless Lender or its broker, as applicable, has actually
received the certificate representing the applicable Conversion Shares no later than the close of business on the relevant Delivery Date
pursuant to the terms set forth above. Moreover, and notwithstanding anything to the contrary herein, in the event Borrower or its transfer
agent refuses to deliver any Conversion Shares without a restrictive securities legend to Lender on grounds that such issuance is in violation
of Rule 144 (“Rule 144”) as promulgated under the Securities Act of 1933, as amended (the “Act”).
Borrower shall deliver or cause its transfer agent to deliver the applicable Conversion Shares to Lender with a restricted securities
legend, but otherwise in accordance with the provisions of this Section 3. In conjunction therewith, Borrower will also deliver
to Lender a written explanation from its counsel or its transfer agent’s counsel opining as to why the issuance of the applicable
Lender Conversion Shares would be in violation of Rule 144.

 

3.4No Fractional Equity Securities.
No fractional securities will be issued upon Conversion. In lieu of a fractional share of any equity security to which Lender would otherwise
be entitled hereunder, the Borrower will pay the cash value of such fractional security to Lender within ten (10) days of Conversion.
The cash value of a fractional share of Common Stock shall be determined according to the applicable Conversion Price.

 

3.5Effect of Conversion. Upon Conversion
of the Outstanding Balance in full, the Borrower shall be forever released from all its obligations and liabilities under this Note.

 

4.        Events
of Default. The occurrence of any of the following shall constitute an event of default (“Event of Default”):

 

4.1Failure to Pay Principal and Interest.
The Borrower fails to pay the principal hereof or interest thereon when due on this Note, whether at maturity or upon acceleration and
such breach continues for a period of five (5) Business Days after written notice from the Lender.

 

4.2 Conversion
and the Shares. The Borrower fails to issue Conversion Securities in accordance with the terms of this Note. It is an obligation
of the Borrower to remain current in its obligations to its transfer agent. It shall be an event of default of this Note, if a conversion
of this Note is delayed, hindered or frustrated due to a balance owed by the Borrower to its transfer agent. If at the option of the Lender,
the Lender advances any funds to the Borrower’s transfer agent in order to process a conversion, such advanced funds shall be paid
by the Borrower to the Lender within forty-eight (48) hours of a demand from the Lender.

 

4.3Breach of Covenants.
The Borrower breaches any material covenant or other material term or condition contained in this Note and any collateral documents including
but not limited to the Purchase Agreement and such breach continues for a period of twenty (20) days after written notice thereof to the
Borrower from the Lender.

 

4.4Breach of Representations
and Warranties. Any representation or warranty of the Borrower made herein or in any agreement, statement or certificate given
in writing pursuant hereto or in connection herewith (including, without limitation, the Purchase Agreement), shall be false or misleading
in any material respect when made and the breach of which has (or with the passage of time will have) a material adverse effect on the
rights of the Lender with respect to this Note or the Purchase Agreement.

 

4.5Receiver or Trustee.
The Borrower or any subsidiary of the Borrower shall make an assignment for the benefit of creditors, or apply for or consent to the appointment
of a receiver or trustee for it or for a substantial part of its property or business, or such a receiver or trustee shall otherwise be
appointed.

 

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4.6Bankruptcy.
Bankruptcy, insolvency, reorganization or liquidation proceedings or other proceedings, voluntary or involuntary, for relief under any
bankruptcy law or any law for the relief of debtors shall be instituted by or against the Borrower or any subsidiary of the Borrower.

  

4.7Delisting of
Common Stock. The Borrower shall fail to maintain the listing of the Common Stock on at least one of the OTC quotation platforms
(which specifically includes the quotation platforms maintained by the OTC Markets Group) or an equivalent replacement exchange, the Nasdaq
National Market, the Nasdaq SmallCap Market, the New York Stock Exchange, or the American Stock Exchange.

  

4.8Liquidation.
Any dissolution, liquidation, or winding up of Borrower or any substantial portion of its business.

 

4.9Cessation of
Operations. Any cessation of operations by Borrower or Borrower admits it is otherwise generally unable to pay its debts as such
debts become due, provided, however, that any disclosure of the Borrower’s ability to continue as a “going concern”
shall not be an admission that the Borrower cannot pay its debts as they become due.

 

4.10Cross-Default.
Notwithstanding anything to the contrary contained in this Note or the other related or companion documents, a breach or default by the
Borrower of any covenant or other term or condition contained in any of the Other Agreements, after the passage of all applicable notice
and cure or grace periods, shall, at the option of the Lender, be considered a default under this Note and the Other Agreements, in which
event the Lender shall be entitled (but in no event required) to apply all rights and remedies of the Lender under the terms of this Note
and the Other Agreements by reason of a default under said Other Agreement or hereunder. “Other Agreements”
means, collectively, all agreements and instruments between, among or by: (1) the Borrower, and, or for the benefit of, (2) the Lender
and any affiliate of the Lender, including, without limitation, promissory notes.

 

14. 11 Remedies. Upon the occurrence
of an Event of Default that has not been timely cured as provided herein:

 

14. 11.1Acceleration of Note. If
there shall be any Event of Default hereunder, in addition to any other remedies that the Lender may have, at the option and upon written
notice to the Borrower (which election and notice shall not be required in any event in the case of an Event of Default under Section
4.5 or 4.6) this Note shall accelerate and the then Outstanding Balance shall become due and payable without presentment, demand,
protest or other notice of any kind, all of which are hereby expressly waived, anything contained herein or in the documents evidencing
the same to the contrary notwithstanding.

 

14. 11.2 Issuance and Delivery of Conversion
Shares. In the event of a default pursuant to Section 4.2, the Lender shall have the right to require the Borrower to issue
and deliver to the Lender any of the Conversion Securities not otherwise issued and delivered to the Lender pursuant to either a Mandatory
Conversion or the Lenders Optional Conversion.

 

14. 11.3 Waiver of Default.
The Lender may (and upon execution of an instrument or instruments in writing by the Lender, the Lender shall be deemed to) rescind an
acceleration or waive any existing Event of Default; in such event, the Lender and the Borrower will be restored to their respective former
positions, rights and obligations hereunder. Any Event of Default so waived will be deemed to have been cured and not to be continuing,
but no such waiver will extend to any subsequent or other Event of Default or impair any right of the Lender consequent thereon.

 

4.17Attorneys’ Fees. In the
event of any default hereunder, the Borrower shall pay all reasonable attorneys’ fees and court costs incurred by Lender in enforcing
and collecting this Note.

 

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5.        Accredited Investor; No
Registration.Lender represents and warrants that Lender is an “accredited investor” as defined in Rule 501(a)
of Regulation D as promulgated by the Securities and Exchange Commission. Lender understands and acknowledges that this Note is not being
registered with the Securities and Exchange Commission under the Act, but instead is being issued under an exemption or exemptions from
the registration and qualification requirements of the Act or other applicable state securities laws. Lender has sufficient knowledge
and experience in business and financial matters to evaluate the Borrower and to make an informed decision with respect to the issuance
of the this Note and the equity securities issuable upon Conversion of this Note. By virtue of the position of Lender with respect to
the Borrower and/or the relationship between Lender and the Borrower, Lender has access to all material information with regard to the
Borrower. Accordingly, Lender has received and reviewed such information and records of the Borrower as Lender deemed necessary, and
the Borrower has made available to the undersigned the opportunity to ask questions of, and to receive answers from, representatives
of the Borrower and to obtain additional information relative to the Borrower and the issuance of the Note and the securities issuable
upon conversion of this Note to the extent the Borrower possesses such information or could acquire it without unreasonable effort or
expense. All such materials and information requested by Lender have been made available and examined by the undersigned.

 

6.        Transfers.This Note may not be offered, sold, assigned
or transferred by the Lender except in compliance with applicable Law.

 

7.        Reissuance
of the Note.

 

7.1Transfer Procedures. If this Note
is to be transferred as permitted under this Note, in whole or in part, the Lender shall surrender this Note to the Borrower, whereupon
the Borrower will issue and deliver a new Note to the Transferee (in accordance with Section 7.4), representing the Outstanding
Balance of this Note being transferred by the Lender and, if less than the entire Outstanding Balance of this Note held by the Lender
is being transferred, a new Note (in accordance with Section 7.4) to the Lender, representing the portion of the Outstanding
Balance not being transferred (each, a “Replacement Note” and collectively, the “Replacement Notes”).
The Lender and the Transferee, by acceptance of this Note, acknowledge and agree that, by reason of the provisions of Section 7.4,
following conversion, redemption or repayment of any portion of this Note, the Outstanding Balance represented by this Note may be
less than the Outstanding Balance stated on the face of this Note.

 

7.2Note Exchangeable for Different Denominations.
This Note is exchangeable, upon the surrender hereof by the Lender at the principal office of the Borrower, for one or more Replacement
Notes representing in the aggregate the Outstanding Balance of this Note in accordance with Section 7.4. Each such Replacement
Note will represent such portion of such Outstanding Balance as is designated by the Lender at the time of such surrender.

 

7.3 Lost, Stolen, Destroyed or Mutilated
Note. Upon receipt by the Borrower of evidence reasonably satisfactory to the Borrower of the loss, theft, destruction or mutilation
of this Note and, in the case of loss, theft or destruction, of any indemnification undertaking by the Lender to the Borrower in customary
form and, in the case of mutilation, upon surrender and cancellation of this Note, the Borrower shall execute and deliver to the Lender
a Replacement Note (in accordance with Section 7.4), representing the Outstanding Balance of the surrendered Note.

 

7.4Issuance of Replacement Notes. Whenever
the Issuer is required to issue a Replacement Note pursuant to the terms of this Note, such Replacement Note (i) shall be of like
tenor with this Note, (ii) shall represent, as indicated on the face of such Replacement Note, the remaining Outstanding Principal
Balance (or, in the case of a Replacement Note being issued pursuant to Section 7.2 or Section 7.2,
the Outstanding Balance designated by the Borrower which, when added to the aggregate Outstanding Balance represented by the other Replacement
Notes issued in connection with such issuance, does not exceed the remaining Outstanding Balance under this Note immediately prior to
such issuance of Replacement Notes), (iv) shall have an issuance date, as indicated on the face of such Replacement Note, which
is the same as the Issuance Date (as defined below) of this Note, (v) shall be deemed to have accrued its proportional share of
the interest under this Note from the immediately preceding Interest Payment Due Date, (vi) shall have the same rights and conditions
as this Note and (vii) shall be timely prepared and issued by the Issuer, but in no event shall the Issuer issue such Replacement
Note more than five (5) Business Days after surrender of this Note or the receipt of the evidence reasonably satisfactory to the
Issuer pursuant to Section 7.3, as the case may be.

 

8.        Effect of Certain Events.

 

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8.1Adjustment
Due to Merger, Consolidation, Etc. If, at any time when this Note is issued and outstanding and prior to conversion of all of
the Note, there shall be any merger, consolidation, exchange of shares, recapitalization, reorganization, or other similar event, as a
result of which shares of Common Stock of the Borrower shall be changed into the same or a different number of shares of another class
or classes of stock or securities of the Borrower or another entity, or in case of any sale or conveyance of all or substantially all
of the assets of the Borrower other than in connection with a plan of complete liquidation of the Borrower, then the Lender of this Note
shall thereafter have the right to receive upon conversion of this Note, upon the basis and upon the terms and conditions specified herein
and in lieu of the shares of Common Stock immediately theretofore issuable upon conversion, such stock, securities or assets which the
Lender would have been entitled to receive in such transaction had this Note been converted in full immediately prior to such transaction
(without regard to any limitations on conversion set forth herein), and in any such case appropriate provisions shall be made with respect
to the rights and interests of the Lender of this Note to the end that the provisions hereof (including, without limitation, provisions
for adjustment of the Conversion Price and of the number of shares issuable upon conversion of the Note) shall thereafter be applicable,
as nearly as may be practicable in relation to any securities or assets thereafter deliverable upon the conversion hereof. The Borrower
shall not affect any transaction described in this Section 8.1 unless (a) it first gives, to the extent practicable, ten (10) days
prior written notice (but in any event at least five (5) days prior written notice) of the record date of the special meeting of shareholders
to approve, or if there is no such record date, the consummation of, such merger, consolidation, exchange of shares, recapitalization,
reorganization or other similar event or sale of assets (during which time the Lender shall be entitled to convert this Note) and (b)
the resulting successor or acquiring entity (if not the Borrower) assumes by written instrument the obligations of this Note. The above
provisions shall similarly apply to successive consolidations, mergers, sales, transfers or share exchanges.

 

8.2 Adjustment
Due to Distribution. If the Borrower shall declare or make any distribution of its assets (or rights to acquire its assets) to
holders of Common Stock as a dividend, stock repurchase, by way of return of capital or otherwise (including any dividend or distribution
to the Borrower’s shareholders in cash or shares (or rights to acquire shares) of capital stock of a subsidiary (i.e., a spin-off))
(a “Distribution”), then the Lender of this Note shall be entitled, upon any conversion of this Note after the
date of record for determining shareholders entitled to such Distribution, to receive the amount of such assets which would have been
payable to the Lender with respect to the shares of Common Stock issuable upon such conversion had such Lender been the holder of such
shares of Common Stock on the record date for the determination of shareholders entitled to such Distribution.

 

9.       Unconditional
Obligation; No Offset. Borrower acknowledges that this Note is an unconditional, valid, binding and enforceable obligation of
Borrower not subject to offset, deduction or counterclaim of any kind. Borrower hereby waives any rights of offset it now has or may have
hereafter against Lender, its successors and assigns, and agrees to make the payments or Conversions called for herein in accordance with
the terms of this Note.

 

10.        Failure
Or Indulgence Not Waiver; Remedies. The Borrower shall not by any act or omission be deemed to waive any of its rights or remedies
under this Note unless such waiver shall be in writing and signed by the Borrower, and then only to the extent specifically set forth
therein. No right or remedy herein conferred upon or reserved to the Borrower is intended to be exclusive of any other right or remedy,
and every right and remedy shall, to the extent permitted by Law, be cumulative and in addition to every other right and remedy given
hereunder or now or hereafter existing at Law, in equity, in tort or otherwise, including injunctive relief or specific performance. The
assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any
other appropriate right or remedy.

 

11. Waiver. The Borrower and all
endorsers and guarantors of, and sureties for, this Note waive presentment for payment, demand, notice of dishonor, protest, and notice
of protest with regard to the Note, all errors, defects and imperfections in any proceedings instituted by the Lender under the terms
of this Note, and all benefits that might accrue to the Borrower by virtue of any present or future laws exempting any property, real
or personal, or any part of the proceeds arising from any sale of any such property, from attachment, levy or sale under execution, or
providing for any stay of execution, exemption from civil process, or extension of time for payment; and the Borrower agrees that any
real estate that may be levied upon pursuant to a judgment obtained by virtue hereof, on any writ of execution issued hereon, may be sold
upon any such writ in whole or in part in any order desired by the Lender.

 

12.       Amendment. Any
provision of this Note may be amended, waived or modified upon the written consent of the Borrower and Lender.

 

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13.       Further
Assurances. Each of the Lender and the Borrower shall take such further actions as are necessary to carry out the intent or the
purposes of this Note (including executing and delivering further agreements, instruments and documents, as the other party may reasonably
request in order to consummate, complete and carry out the actions or transactions contemplated hereby and the intent of the parties hereunder.

 

14.    Assignment By The
Borrower. Except as specifically permitted under this Note the rights, interests or obligations hereunder may not be assigned
or delegated, by operation of law or otherwise, in whole or in part, by the Borrower without the prior written consent of the Lender.

 

15.       No Voting
Or Other Rights. This Note does not entitle the Lender to any voting rights or other rights as a stockholder of the Borrower unless
and until (and only to the extent that) this Note is actually converted into shares of the Borrower’s Capital Stock in accordance
with its terms (and in such case, only such rights as are applicable to such shares of the Borrower’s Capital Stock). In the absence
of conversion of this Note into Conversion Securities, no provisions of this Note and no enumeration herein of the rights or privileges
of the Lender shall cause the Lender to be a stockholder of the Borrower for any purpose.

 

16.        Failure
Or Indulgence Not Waiver; Remedies. The Lender shall not by any act or omission be deemed to waive any of its rights or remedies
under this Note unless such waiver shall be in writing and signed by the Lender, and then only to the extent specifically set forth therein.
No right or remedy herein conferred upon or reserved to the Lender is intended to be exclusive of any other right or remedy, and every
right and remedy shall, to the extent permitted by Law, be cumulative and in addition to every other right and remedy given hereunder
or now or hereafter existing at Law, in equity, in tort or otherwise, including injunctive relief or specific performance. The assertion
or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate
right or remedy.

 

17.   Time is of the Essence.
Time is of the essence with respect to all matters hereunder.

 

18.        Severability.
If any part of this Note is construed to be in violation of any law, such part shall be modified to achieve the objective of Borrower
and Lender to the fullest extent permitted by law and the balance of this Note shall remain in full force and effect.

 

19.        Remedies.
The Borrower acknowledges that a breach by it of its obligations hereunder will cause irreparable harm to the Lender, by vitiating the
intent and purpose of the transaction contemplated hereby. Accordingly, the Borrower acknowledges that the remedy at law for a breach
of its obligations under this Note will be inadequate and agrees, in the event of a breach or threatened breach by the Borrower of the
provisions of this Note, that the Lender shall be entitled, in addition to all other available remedies at law or in equity, and in addition
to the penalties assessable herein, to an injunction or injunctions restraining, preventing or curing any breach of this Note and to enforce
specifically the terms and provisions thereof, without the necessity of showing economic loss and without any bond or other security being
required.

 

20.       Interpretation.
This Note shall be deemed to be jointly drafted by the Borrower and the Lender and shall not be construed against any Person as the drafter
hereof. In this Note, unless otherwise indicated or the context otherwise requires, all words and personal pronouns relating thereto shall
be read and construed as the number and gender of the party or parties required and the verb shall be read and construed as agreeing with
the required word and pronoun; the division of this Note into Sections, clauses and sub-clauses and the use of headings
and captions is for convenience of reference only and shall not modify or affect the interpretation or construction of this Note or any
of its provisions; the words “herein,” “hereof,” “hereunder,” “hereinafter” and “hereto”
and words of similar import refer to this Note as a whole and not to any particular Section, clause or sub-clause hereof;
the words “include,” “including,” and derivations thereof shall be deemed to have the phrase “without limitation”
attached thereto unless otherwise expressly stated; references to a specified Section, clause or sub-clause shall be construed
as a reference to that specified Section, clause or sub-clause of this Note; and all references to “$” or “dollars”
shall be deemed references to United States dollars.

 

21.       Definitions.

 

For purposes of this Agreement the following terms shall
have the meanings set forth below:

 

    	 	7	 

     

    

“Act” has the meaning ascribed
to it in Section 3.3.

 

“Affiliate” means, with respect
to any specified Person, any other Person who, directly or indirectly, controls, is controlled by, or is under common control with such
Person, including without limitation any general partner, managing member, officer, director or trustee of such Person, or any venture
capital fund, registered investment company or other investment fund now or hereafter existing that is controlled by one or more general
partners, managing members or investment advisers of, or shares the same management company or investment adviser with, such Person. Solely
for purposes of this definition, the term “control” when used with respect to any Person shall mean the power
to direct the management or policies of such Person, directly or indirectly, whether through ownership of voting securities, by contract
or otherwise, and the terms “controlling” and “controlled” shall have meanings correlative
to the foregoing.

 

“Affiliate Transfer” has the
meaning ascribed to it in Section 6.4.

 

“Borrower” has the meaning ascribed
to it in the introductory paragraph of this Note.

 

“Business Day” means any day
that is not a Saturday, Sunday or other day on which commercial banks in New York City are authorized or required by Law to remain closed.

 

“Common Stock” has the meaning
ascribed to it in Section 3.2.

 

“Conversion Amount” has the meaning
ascribed to it in Section 3.2.

 

“Conversion Price” has the meaning
ascribed to it in Section 3.2.1.

 

“Conversion Securities” means
any Mandatory Equity Securities or Lender Conversion Shares.

 

“Distribution” has the meaning
ascribed to it in Section 8.2.

 

“DTC” means the Depository Trust
Company or any successor thereto.

 

“DTC/FAST Program” means the
DTC’s Fast Automated Securities Transfer program.

 

“DWAC” means the DTC’s
Deposit/Withdrawal at Custodian system.

 

“DWAC Eligible” means that (a)
Borrower’s Ordinary Shares are eligible at DTC for full services pursuant to DTC’s operational arrangements, including without
limitation transfer through DTC’s DWAC system; (b) Borrower has been approved (without revocation) by DTC’s underwriting department;
(c) Borrower’s transfer agent is approved as an agent in the DTC/FAST Program; (d) the Conversion Shares are otherwise eligible
for delivery via DWAC; and (e) Borrower’s transfer agent does not have a policy prohibiting or limiting delivery of the Conversion
Shares via DWAC.

 

“Equity Securities” has the meaning
ascribed to it in Section 3.1.

 

“Event of Default” has the meaning
ascribed to it in Section 4.

 

“Governmental Authority” means
the government of the United States, any other nation, or any political subdivision thereof, whether state, provincial or local, and any
agency, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial,
taxing, regulatory or administrative powers or functions of or pertaining to government (including any supra-national bodies).

 

“Issuance Date” means March 18,
2022.

 

    	 	8	 

     

    

“Law” means any law (including
common law), constitution, statute, treaty, regulation, rule, ordinance, code, ruling, or order of, including the administration thereof
by any Governmental Authority charged with the enforcement, interpretation or administration thereof, or any agreement with, any Governmental
Authority.

 

“Lender” has the meaning ascribed
to it in the introductory paragraph of this Note.

 

“Lender Conversion Shares” has
the meaning ascribed to it in Section 3.2.

 

“Lender Optional Conversion”
has the meaning ascribed to it in Section 3.2.

 

“Lender Conversion Notice” has
the meaning ascribed to it in Section 3.2.

 

“Mandatory Conversion” has the
meaning ascribed to it in Section 3.1.

 

“Mandatory Conversion Price”
has the meaning ascribed to it in Section 3.1.

 

“Mandatory Equity Securities”
has the meaning ascribed to it in Section 3.1.

 

“Maturity Date” has the meaning
ascribed to it in the introductory paragraph of this Note.

 

“Note” has the meaning ascribed
to it in the introductory paragraph of this Note.

 

“Other Agreements” has the meaning
ascribed to it in Section 14.10.

 

“Original Principal Amount” is
the amount specified above the introductory paragraph of this Note.

 

“Outstanding Balance” means as
of any date of determination, the Original Principal Amount, as reduced or increased, as the case may be, pursuant to the terms hereof
for payment, Conversion, offset, or otherwise, plus accrued but unpaid interest, collection and enforcements costs (including attorneys’
fees) incurred by Lender, transfer, stamp, issuance and similar taxes and fees related to the Note, and any other fees or charges incurred
under this Note.

 

“Person” shall mean any individual,
corporation, limited liability company, partnership, association, trust or other entity or organization.

 

“Prepayment Amount” has the meaning
ascribed to it in Section 1.2.1.

 

“Prepayment Date” has the meaning
ascribed to it in Section 1.2.1.

 

“Prepayment Notice” has the meaning
ascribed to it in Section 1.2.

 

“Qualified Financing” has the
meaning ascribed to it in Section 3.1.

 

“Replacement Note” or “Replacement
Notes” have the meaning ascribed them in Section 7.1.

 

“Rule 144” has the meaning ascribed
to it in Section 3.3.

 

 “Trading Day” means any
day on which the OTC Market Pink-Current Information (or such other principal market for the Common Stock) is open for trading.

 

22.    Notices. All notices,
demands, requests, consents, approvals, and other communications required or permitted hereunder shall be in writing and, unless otherwise
specified herein, shall be (i) personally served, (ii) deposited in the mail, registered or certified, return receipt requested, postage
prepaid, (iii) delivered by reputable air courier service with charges prepaid, or (iv) transmitted by hand delivery, telegram, facsimile
or email, addressed as set forth below or to such other address as such party shall have specified most recently by written notice. Any
notice or other communication required or permitted to be given hereunder shall be deemed effective (a) upon hand delivery or delivery
by facsimile, with accurate confirmation generated by the transmitting facsimile machine, at the address or number designated below (if
delivered on a Business Day during normal business hours where such notice is to be received), or the first business day following such
delivery (if delivered other than on a Business Day during normal business hours where such notice is to be received) or (b) on the second
Business Day following the date of mailing by express courier service, fully prepaid, addressed to such address, or upon actual receipt
of such mailing, whichever shall first occur. The addresses for such communications shall be:

 

    	 	9	 

     

    

If to the Borrower, to:

 

RenovaCare, Inc.

9375 E Shea Blvd 107 -A

Scottsdale, AZ 85260

Attention: President and Chief Executive Officer

 

If to Lender, to:

 

Kalen Capital Corporation

688 West Hastings
Street

Vancouver, British
Columbia, V6B 1P1

Canada 

Attention: President

 

or, to such other address as either the Borrower or the
Lender may specify by notice given in accordance with this Section.

 

23.    Governing Law.
This Note shall be governed by and construed in accordance with the laws of the State of New York without regard to principles of conflicts
of laws. Any action brought by either party against the other concerning the transactions contemplated by this Note shall be brought only
in the state courts of New York or in the federal courts located in the Southern District of New York. The parties to this Note hereby
irrevocably waive any objection to jurisdiction and venue of any action instituted hereunder and shall not assert any defense based on
lack of jurisdiction or venue or based upon forum non conveniens. The Borrower and Lender waive trial by jury. The prevailing
party shall be entitled to recover from the other party its reasonable attorney's fees and costs. In the event that any provision of this
Note or any other agreement delivered in connection herewith is invalid or unenforceable under any applicable statute or rule of law,
then such provision shall be deemed inoperative to the extent that it may conflict therewith and shall be deemed modified to conform with
such statute or rule of law. Any such provision which may prove invalid or unenforceable under any law shall not affect the validity or
enforceability of any other provision of any agreement. Each party hereby irrevocably waives personal service of process and consents
to process being served in any suit, action or proceeding in connection with this Note, any agreement or any other document delivered
in connection with this Note by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery)
to such party at the address in effect for notices to it under this Note and agrees that such service shall constitute good and sufficient
service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any
other manner permitted by law.

 

 

 

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    	 	10	 

     

    

IN WITNESS WHEREOF, the Borrower has caused this Note to be issued
as of the Issuance Date.

 

 

RenovaCare, Inc.

 

 

 

 

By: ____________________________

 

Name: Kaiyo Nedd

Title: President and Chief Executive Officer

 

 

 

Agreed and Accepted:

 

Kalen Capital Corporation

 

 

 

 

By: ____________________________

 

Name: Harmel S. Rayat

Title: President

    	 	11	 

     

    

EXHIBIT A

 

Kalen Capital Corporation

688 West Hastings St.

 Vancouver, British
Columbia,

V6B 1P1, Canada

_________,202__

 

RenovaCare, Inc.

9375 E Shea Blvd.

Suite 107 A

Scottsdale, AZ 85260

 

Re: Convertible Promissory Note Issued March ▲,
2022

 

LENDER CONVERSION NOTICE

 

The above-captioned Lender hereby gives notice to RenovaCare, Inc. (the “Borrower”),
pursuant to that certain Convertible Promissory Note made by Borrower in favor of Lender on March ▲, 2022 (the “Note”),
that Lender elects to convert the portion of the Outstanding Balance of the Note set forth below into fully paid and non-assessable shares
of the Borrower’s Common Stock as of the date of conversion specified below. Said conversion shall be based on the Conversion Price
set forth below. In the event of a conflict between this Lender Conversion Notice and the Note, the Note shall govern, or, in the alternative,
at the election of Lender in its sole discretion, Lender may provide a new form of Lender Conversion Notice to conform to the Note. Capitalized
terms used in this notice without definition shall have the meanings given to them in the Note.

 

	 	A.	Date of Conversion:	 	 	 __________________________	 	 
	 	B.	Lender Conversion #:	 	 	 __________________________	 	 
	 	C.	Conversion Amount:	 	 	 __________________________	 	 
	 	D.	Conversion Price:	 	 	 __________________________	 	 
	 	E.	Lender Conversion Shares:	 	 __________________________	  (C divided by D)
	 	F.	Remaining Outstanding Balance of Note: __________________	 	*

* Subject to adjustments for corrections, defaults, interest and other adjustments
permitted by the terms of the Note.

 

Please transfer the Lender Conversion Shares electronically (via DWAC)
to the following account:

	Broker:	 	 	Address:	 
	DTC#:	 	 	 	 
	Account #:	 	 	 	 
	Account Name:	 	 	 	 

 

To the extent the Lender Conversion Shares are not able
to be delivered to Lender electronically via the DWAC system, deliver all such certificated shares to Lender via reputable overnight courier
after receipt of this Lender Conversion Notice (by facsimile transmission or otherwise) to:

_____________________________________

_____________________________________

_____________________________________

 

If the Certificates are being delivered with imprinted restrictive legends,
please also simultaneously deliver the Company’s counsel’s explanation for so doing.

 

Very truly yours,

 

Kalen Capital Corporation

 

 

 

By: ____________________________

 

Name:

Title:

 

 

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