Document:

EX-10.1

 Exhibit 10.1 
  

 
  

INVESTMENT AGREEMENT 

by and among 
 THE
PURCHASERS NAMED HEREIN 
 and 

MILESTONE SCIENTIFIC INC. 

APRIL 15, 2014 
  

 
  

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
			
	 SECTION 1.
	 	AUTHORIZATION OF SECURITIES	  	 	1	  
			
	 SECTION 2.
	 	PURCHASE AND SALE OF SECURITIES	  	 	1	  
			
	 2.1.
	 	Issuance and Sale of Securities	  	 	1	  
	 2.2.
	 	Closing and Closing Date	  	 	1	  
			
	 SECTION 3.
	 	REPRESENTATIONS AND WARRANTIES OF THE COMPANY	  	 	2	  
			
	 3.1.
	 	Corporate Organization	  	 	2	  
	 3.2.
	 	No Subsidiaries	  	 	2	  
	 3.3.
	 	Capitalization	  	 	3	  
	 3.4.
	 	Authorization	  	 	4	  
	 3.5.
	 	No Conflicts	  	 	4	  
	 3.6.
	 	Approvals	  	 	5	  
	 3.7.
	 	Reports and Financial Statements	  	 	5	  
	 3.8.
	 	Absence of Certain Developments	  	 	7	  
	 3.9.
	 	Compliance	  	 	8	  
	 3.10.
	 	Litigation	  	 	9	  
	 3.11.
	 	Absence of Undisclosed Liabilities	  	 	9	  
	 3.12.
	 	Change in Ownership	  	 	9	  
	 3.13.
	 	Employment Matters	  	 	9	  
	 3.14.
	 	Tax Matters	  	 	11	  
	 3.15.
	 	Contracts	  	 	11	  
	 3.16.
	 	Intellectual Property	  	 	14	  
	 3.17.
	 	Insurance	  	 	16	  
	 3.18.
	 	Environmental Liability	  	 	16	  
	 3.19.
	 	Transactions with Related Parties	  	 	16	  
	 3.20.
	 	Property	  	 	16	  
	 3.21.
	 	Indebtedness	  	 	17	  
	 3.22.
	 	Accuracy of Information	  	 	17	  
	 3.23.
	 	Registration Rights; Voting Rights	  	 	17	  
	 3.24.
	 	Private Offering	  	 	17	  
	 3.25.
	 	Investment Banking	  	 	18	  
	 3.26.
	 	Takeover Provision	  	 	18	  
	 3.27.
	 	Miscellaneous Securities Law Matters	  	 	18	  
	 3.28.
	 	Accountants	  	 	18	  
	 3.29.
	 	[Reserved.]	  	 	18	  
	 3.30.
	 	No Integrated Offering	  	 	18	  
	 3.31.
	 	Questionable Payments	  	 	19	  
	 3.32.
	 	Suppliers	  	 	19	  
	 3.33.
	 	Product Liability	  	 	19	  
	 3.34.
	 	FDA and Related Matters	  	 	19	  

  
 (i) 

							
	 SECTION 4.
	 	REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS	  	 	21	  
			
	 SECTION 5.
	 	ADDITIONAL AGREEMENTS OF THE PARTIES	  	 	23	  
			
	 5.1.
	 	Preemptive Rights	  	 	23	  
	 5.2.
	 	Reasonable Best Efforts; Further Assurances	  	 	25	  
	 5.3.
	 	Indemnity	  	 	26	  
	 5.4.
	 	Consents and Approvals	  	 	28	  
	 5.5.
	 	Use of Proceeds	  	 	28	  
	 5.6.
	 	Takeover Provisions	  	 	28	  
	 5.7.
	 	Section 16 Matters	  	 	29	  
	 5.8.
	 	Registration and Quotation	  	 	29	  
	 5.9.
	 	Private Offering	  	 	29	  
	 5.10.
	 	Blue Sky	  	 	29	  
	 5.11.
	 	Board Representation and Strategic Investment Committee	  	 	30	  
	 5.12.
	 	Corporate Opportunity	  	 	32	  
	 5.13.
	 	Legends	  	 	33	  
	 5.14.
	 	Rights Relating to Dental Business	  	 	34	  
			
	 SECTION 6.
	 	CONDITIONS TO THE CLOSING	  	 	34	  
			
	 6.1.
	 	Conditions to the Obligations of Purchasers To Close	  	 	34	  
			
	 SECTION 7.
	 	INTERPRETATION OF THIS AGREEMENT	  	 	36	  
			
	 7.1.
	 	Terms Defined	  	 	36	  
	 7.2.
	 	Accounting Principles	  	 	44	  
	 7.3.
	 	Governing Law	  	 	44	  
	 7.4.
	 	Paragraph and Section Headings	  	 	44	  
			
	 SECTION 8.
	 	COVENANTS OF THE COMPANY PRIOR TO CLOSING DATE	  	 	44	  
			
	 8.1.
	 	Access	  	 	44	  
	 8.2.
	 	Operation of the Business	  	 	44	  
	 8.3.
	 	Negative Covenant	  	 	45	  
	 8.4.
	 	Notification	  	 	45	  
	 8.5.
	 	No Negotiation	  	 	45	  
			
	 SECTION 9.
	 	MISCELLANEOUS	  	 	45	  
			
	 9.1.
	 	Notices	  	 	45	  
	 9.2.
	 	Expenses	  	 	46	  
	 9.3.
	 	Reproduction of Documents	  	 	46	  
	 9.4.
	 	Survival	  	 	47	  
	 9.5.
	 	Successors and Assigns	  	 	47	  
	 9.6.
	 	Entire Agreement; Amendment and Waiver	  	 	47	  
	 9.7.
	 	Severability	  	 	47	  
	 9.8.
	 	Lost Certificates Evidencing Securities; Exchange	  	 	48	  

  
 (ii) 

							
	 9.9.
	 	Terms Generally	  	 	48	  
	 9.10.
	 	Draftsmanship	  	 	48	  
	 9.11.
	 	Counterparts	  	 	49	  
	 9.12.
	 	Several and Not Joint	  	 	49	  
	 9.13.
	 	Specific Performance	  	 	49	  
	 9.14.
	 	No Recourse	  	 	50	  

  

			
	Exhibit A	  	Series A Preferred Certificate of Designation
	Exhibit B	  	Opinion of Golenbock Eiseman Assor Bell & Peskoe LLP
	Exhibit C	  	Registration Rights Agreement

  
 (iii) 

 MILESTONE SCIENTIFIC INC. 

INVESTMENT AGREEMENT 

Dated as of April 15, 2014 

Milestone Scientific Inc., a Delaware corporation (the “Company”), hereby agrees with BP4 S.p.A., an Italian corporation
(together with all Affiliates designated by it as purchasers of any Securities hereunder prior to the Closing Date and their respective successors, assigns or transferees, including any transferee of the Securities (as defined herein), a
“Purchaser” and collectively the “Purchasers”), as follows: 
 SECTION 1. AUTHORIZATION OF SECURITIES 

The Company has duly authorized the issuance and sale of (i) 2,000,000 shares of the Company’s authorized but unissued shares of
common stock, par value $0.001 per share (the “Common Stock”) and (ii) 7,000 shares of the Company’s Series A Convertible Preferred Stock, par value $0.001 per share (“Series A Preferred Stock”), which
shares of Series A Preferred Stock will be, upon issuance, convertible into authorized but unissued shares of Common Stock and will have the terms set forth in the Certificate of Designation for such Series A Preferred Stock set forth as Exhibit
A hereto (the “Certificate of Designation”). References to a “Schedule” or an “Exhibit” are, unless otherwise specified, to a Schedule or an Exhibit to this Agreement, including the Transaction Documents.
Capitalized terms used herein and not otherwise defined shall have the meanings ascribed to such terms in Section 7.1 of this Agreement. 

SECTION 2. PURCHASE AND SALE OF SECURITIES 

2.1. Issuance and Sale of Securities. Subject to the terms and conditions set forth in this Agreement, and in reliance upon the
Company’s and each Purchaser’s representations set forth herein, on the Closing Date (as defined below), the Company shall issue and sell to the Purchasers free and clear of all Liens, and the Purchasers shall severally purchase from the
Company, the number of shares of Common Stock and Series A Preferred Stock set forth opposite each Purchaser’s name on Schedule 2.1 (collectively such shares are referred to as the “Securities”) for the aggregate cash
purchase price set forth opposite each Purchaser’s name on Schedule 2.1 for such Securities (such aggregate purchase price, the “Total Purchase Price”). The purchase and sale of the Securities shall be effected on the
Closing Date by the Company executing and delivering to the Purchasers, duly registered in each Purchaser’s name, duly executed stock certificates evidencing the Securities being purchased by each Purchaser, against delivery by such Purchaser
to the Company of the portion of Total Purchase Price payable by such Purchaser, by wire transfer of immediately available funds to the Company’s bank account previously provided to the Purchasers by the Company (the “Company Bank
Account”). 
 2.2. Closing and Closing Date. The closing of the transactions contemplated by Section 2.1 of this
Agreement (the “Closing”) shall take place at 10:00 a.m., New York City time, on the Closing Date. The Closing shall take place at the offices of Golenbock Eiseman Assor Bell & Peskoe LLP, 437 Madison Avenue, New York, NY,
or such other location as the Purchasers and the Company shall mutually select. 

 SECTION 3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY 

The following representations and warranties by the Company to the Purchasers are qualified in their entirety by reference to the disclosure
(i) in the Company SEC Reports and (ii) set forth in the disclosure letter (the “Company Disclosure Letter”) delivered by the Company to each Purchaser concurrently with the execution of this Agreement. Each disclosure set
forth in the Company Disclosure Letter shall identify items of disclosure by reference to a particular Section or Subsection of this Agreement; provided, however, that any disclosure contained in any section of the Company Disclosure
Letter shall qualify or modify each of the representations and warranties set forth in this Section 3 to the extent the applicability of the disclosure to such other section is reasonably apparent from the text of the disclosure made. Subject
to the foregoing, the Company hereby represents and warrants to the Purchasers that as of the date hereof and each Closing Date (except to the extent made only as of a specified date, in which case as of such date): 

3.1. Corporate Organization.  

(a) The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Purchasers
have been provided true and complete copies of the Certificate of Incorporation of the Company and Bylaws of the Company, in each case as in effect immediately prior to the Closing. 

(b) The Company has all requisite corporate power and corporate authority to own its properties and to carry on its business as now conducted.
The Company has all requisite power and authority to execute and deliver this Agreement and the Transaction Documents and to perform its obligations hereunder and thereunder. 

(c) The Company and the Medical JV have each filed all necessary documents to qualify to do business as a foreign corporation in, and the
Company is in good standing under, the laws of each jurisdiction in which the conduct of the Company’s business or the nature of the property owned requires such qualification, except where the failure to so qualify would not have, or would not
reasonably be expected to have, a Material Adverse Effect. 
 3.2. No Subsidiaries.  

(a) Other than 10,000,000 shares of common stock of the Medical JV, the Company does not own any equity interest in or control, directly or
indirectly, any corporations, partnerships, limited liability partnerships, limited liability companies, associations or other entities. 

(b) On the date hereof, the authorized capital stock of the Medical JV consists of 50,000,000 shares of its Common Stock, 22,000,000 of which
were issued and outstanding, and 5,000,000 shares of preferred stock, none of which were issued and outstanding, no shares of Common Stock were reserved for issuance pursuant to the Medical JV’s option plans and equity incentive programs and
there are no warrants to purchase shares of common stock or preferred stock, or any other equity security of the Medical JV issuable upon conversion, exchange or exercise of any security of, the Medical JV. 

  
 - 2 - 

 3.3. Capitalization. 

(a) On the date hereof, the authorized capital stock of the Company consists of 50,000,000 shares of its Common Stock and 5,000,000 shares of
preferred stock, par value $0.001 per share (the “Authorized Preferred Stock”), 7,000 of which has been designated as Series A Convertible Preferred Stock in accordance with the terms of the Transaction Documents. As of the close of
business on the Business Day prior to the date of this Agreement, (i) 17,875,465 shares of Common Stock were issued, 1,839,930 shares of Common Stock were to be issued and 17,842,132 shares were outstanding and there were 33,333 shares of
Common Stock held in the treasury of the Company, (ii) no shares of Authorized Preferred Stock were issued and outstanding, (iii) options and warrants to purchase up to 1,568,855 shares of Common Stock were issued and outstanding, as
described in the Company SEC Reports and (iv) 3,375,812 shares of Common Stock were reserved for issuance pursuant to the Company’s option plans and equity incentive programs as described in the Company SEC Reports. Since the Business Day
prior to the date of this Agreement until the Closing, except in connection with the transactions contemplated by the Transaction Documents or in connection with the issuance of Common Stock upon the exercise of options or warrants then outstanding,
the Company has not (x) issued or authorized the issuance of any shares of Common Stock or Authorized Preferred Stock, or any securities convertible into or exchangeable or exercisable for shares of Common Stock or Authorized Preferred Stock,
(y) reserved for issuance any shares of Common Stock or Authorized Preferred Stock or (z) repurchased or redeemed, or authorized the repurchase or redemption of, any shares of Common Stock or Authorized Preferred Stock. On a pro forma
basis, as of the Closing (assuming that the Securities have been issued as set forth on Schedule 2.1 hereto and that no options have been exercised since the close of business on the Business Day prior to the date of this Agreement),
(1) 19,875,465 shares of Common Stock will be issued and outstanding and 33,333 shares will be held in the treasury of the Company, (2) 4,666,667 shares of Series A Preferred Stock will be issued and outstanding, (3) 2,750,491 shares
of Common Stock will be reserved for issuance pursuant to conversion of the Series A Preferred Stock at the Optional Conversion Price, (4) options and warrants to purchase up to 1,568,855 shares of Common Stock will be issued and outstanding,
(5) 3,375,812 shares of Common Stock will be reserved for issuance pursuant to the Company’s option plans and equity incentive programs and (6) except as set forth in the foregoing clause (2), no shares of Authorized Preferred Stock
will be issued and outstanding. No bonds, debentures, notes or other indebtedness having the right to vote on any matters on which the stockholders of the Company may vote are issued and outstanding. 

(b) All of the outstanding shares of capital stock of the Company have been duly and validly issued and are fully paid and non-assessable, and
were issued in compliance with the Securities Act and any relevant state securities laws. Upon issuance, sale and delivery as contemplated by this Agreement, (i) each of the Securities and (ii) upon conversion of the Series A Preferred
Stock to Common Stock in accordance with the terms of the Certificate of Designation, the shares of Common Stock into which it shall have been converted will, in each case, be duly authorized, validly issued, fully paid and non-assessable, and free
and clear of any and all security interests, pledges, liens, charges, claims, options, restrictions on transfer, preemptive or similar rights, proxies and voting or other agreements, or other encumbrances of any nature whatsoever, except for those
resulting from the actions of the Purchasers or provided for herein or in the Transaction Documents and other than restrictions on transfer imposed by federal or state securities laws. 

  
 - 3 - 

 (c) Except for the Series A Conversion Shares and 3,375,812 shares of Common Stock reserved for
issuance pursuant to the Company’s option plans and equity incentive programs as described in the Company SEC Reports, on the Closing Date there will be no shares of Common Stock or any other equity security of the Company issuable upon
conversion, exchange or exercise of any security of the Company or any of its Subsidiaries, nor will there be any rights, options, calls or warrants outstanding or other agreements to acquire shares of Common Stock or any other equity securities of
the Company, nor will the Company be contractually obligated to purchase, redeem or otherwise acquire any of its outstanding shares. Except as contemplated by this Agreement, (i) no stockholder of the Company is entitled to any preemptive or
similar rights to subscribe for shares of capital stock of the Company, (ii) no stockholder of the Company has any rights, contractual or otherwise, to designate members of the Board, other than in accordance with the DGCL, and (iii) to
the Company’s knowledge, there are no stockholder, voting or other agreements relating to the rights and obligations of the Company’s stockholders. 

3.4. Authorization. 
 The
Company has the requisite corporate power and authority to (a) execute, deliver and perform its obligations under this Agreement and the Transaction Documents and (b) to consummate each of the transactions contemplated hereby and thereby.
The execution and delivery of this Agreement and the Transaction Documents by the Company and the performance by the Company of its obligations hereunder and thereunder and the consummation of the transactions contemplated hereby and thereby have
been duly authorized by the Board. No other corporate or stockholder action is necessary to authorize such execution, delivery and performance of this Agreement and the Transaction Documents. Upon execution and delivery, this Agreement and the
Transaction Documents shall constitute the valid and binding obligation of the Company, enforceable against the Company in accordance with their respective terms, except that such enforcement may be subject to bankruptcy, insolvency, reorganization,
moratorium or other similar laws now or hereafter in effect relating to creditors’ rights and general principles of equity. The Company has authorized the issuance and delivery of the Securities and the Series A Conversion Shares in accordance
with this Agreement, and no further corporate or stockholder action is required in connection with such issuance and delivery. 
 3.5. No
Conflicts. 
 (a) The execution, delivery and performance by the Company of this Agreement and the Transaction Documents, and the
consummation of the transactions contemplated hereby and thereby, including the issuance of the Securities and the Series A Conversion Shares, do not, and will not, (a) conflict with, or result in a violation of, any provision of any law,
ordinance, permit, concession, grant, franchise, statute, rule or regulation or any judgment, ruling, order, writ, injunction or decree applicable to the Company or the Medical JV or any of their respective properties or assets, (b) conflict
with or result in a violation of any provision of the Organizational Documents or the comparable organizational documents of the Medical JV or (c) conflict with, result in a violation or breach of, constitute (with or without due notice or
lapse of time or both) a default (or give rise to any right of termination, cancellation or acceleration) under, or result in the creation of, any Lien on any property or asset of the Company or the Medical JV or in any obligation by the Company or
the Medical JV to purchase or redeem, or offer to purchase or redeem, any capital stock or other securities of the Company the Medical JV, under any Contract to which the Company the Medical JV is a party or by which the Company the Medical JV or
any of their respective properties may be bound; except, in each of the cases of clauses (a) or (c) where any such conflict, violation or breach would not reasonably be expected to, individually or in the aggregate, have a Material Adverse
Effect. There are no material consents, waivers and approvals under any Contracts required to be obtained by the Company or the Medical JV in connection with the Company’s entering into this Agreement or any of the Transaction Documents or the
consummation of the transactions contemplated hereby or thereby. 

  
 - 4 - 

 3.6. Approvals. 

The execution and delivery by the Company of this Agreement and the Transaction Documents do not, and the performance of its obligations
hereunder and thereunder and the consummation of the transactions contemplated hereby and thereby by the Company will not, require any consent, approval, authorization or permit of, or registration or filing with or notification to, any Governmental
Authority, except (a) the filing of Current Reports on Form 8-K as required by the Exchange Act, (b) the filing of any filings required under state securities laws, (c) the filing of the Certificate of Designation with the Secretary
of State of the State of Delaware and (d) any such consent, approval, authorization, registration, filing or notification for which the failure to obtain or make would not reasonably be expected to have a Material Adverse Effect. 

3.7. Reports and Financial Statements 

(a) The Company has filed with the SEC all forms, registration statements, reports, schedules and statements and other documents (including
exhibits thereto) required to be filed by it under the Exchange Act and Securities Act, including pursuant to Section 13(a) or 15(d) of the Exchange Act, since January 1, 2011 (such forms, reports, schedules, statements and other
documents, including the exhibits thereto and documents incorporated by reference therein, in each case, as amended, supplemented or superseded, being hereinafter referred to collectively as the “Company SEC Reports”), on a timely
basis or has received a valid extension of such time of filing and has filed such Company SEC Reports prior to the expiration of any such extension. Each Company SEC Report at the time filed (i) did not contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading and (ii) complied in all material
respects with all applicable requirements of the Exchange Act and Securities Act. No executive officer of the Company has failed in any respect to make the certifications required of him or her under Section 302 or 906 of the Sarbanes-Oxley
Act. As of the date hereof, to the Company’s knowledge none of the Company SEC Reports, nor any registration statement filed under the Securities Act, is the subject of any ongoing SEC review, outstanding SEC comment or outstanding SEC
investigation. 

  
 - 5 - 

 (b) The audited consolidated financial statements and unaudited interim financial statements of
the Company included in the Company SEC Reports (i) have been prepared from, and are in accordance in all material respects with, the books and records of the Company and its Subsidiaries, (ii) complied as to form in all material respects
with applicable accounting requirements and with the published rules and regulations of the SEC with respect thereto as in effect at the date of filing, (iii) have been prepared in accordance with generally accepted accounting principles in the
United States of America (“GAAP”) applied on a consistent basis during the periods involved (except as may be indicated in the notes thereto or, in the case of unaudited interim financial statements, which may not contain all notes
required by GAAP, for normal year-end adjustments that are not material in amount or scope to the extent permitted by the SEC on Form 10-Q, Form 8-K or any like form under the Exchange Act), and (iv) present fairly, in all material respects,
the financial position of the Company as at the dates thereof and the results of their operations and cash flow for the periods then ended subject, in the case of the unaudited interim financial statements, to normal year-end audit adjustments. 

(c) The records, systems, controls, data and information of the Company are recorded, stored, maintained and operated under means (including
any electronic, mechanical or photographic process, whether computerized or not) that are under the exclusive ownership and direct control of the Company or accountants (including all means of access thereto and therefrom), except for any
nonexclusive ownership and nondirect control that would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the system of internal accounting controls described below in Section 3.7(d). 

(d) The Company has implemented and maintains disclosure controls and procedures (as defined in Rule 13a-15(e) of the Exchange Act) that are
designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the Company’s management, including its principal executive and
principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure. The Company maintains internal control over financial reporting (as defined in Rule 13a-15(f) of the
Exchange Act), which is sufficient to provide reasonable assurances that (a) transactions are executed in accordance with management’s general or specific authorization; (b) transactions are recorded as necessary to permit preparation
of financial statements in conformity with GAAP and maintain accountability for assets; and (c) access to assets is permitted only in accordance with management’s general or specific authorization. The Company’s internal control over
financial reporting was effective as of December 31, 2013 and the Company is not aware of any material weakness in its internal control over financial reporting. Since December 31, 2013, there has been no change in the Company’s
internal control over financial reporting or disclosure controls and procedures or, to the knowledge of the Company, in other factors that could significantly affect the Company’s internal controls. 

  
 - 6 - 

 (e) The Company has disclosed, based on its most recent evaluation prior to the date of this
Agreement, to the Company’s outside auditors and the audit committee of the Board (x) any significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting that are reasonably likely
to adversely affect the Company’s ability to record, process, summarize and report financial information, and (y) any fraud, whether or not material, that involves management or other employees who have a significant role in the
Company’s internal controls over financial reporting, in each case of which it is aware. As of the date of this Agreement, the Company has no knowledge of any reason that its outside auditors and its principal executive officer and principal
financial officer will not be able to give the certifications and attestations required pursuant to the rules and regulations adopted pursuant to Section 404 of the Sarbanes-Oxley Act, without qualification, when next due. Since
December 31, 2011, (i) neither the Company nor any of its Subsidiaries nor, to the knowledge of the Company, any director, officer, employee, auditor, accountant or representative of the Company or any of its Subsidiaries has received or
otherwise had or obtained knowledge of any material complaint, allegation, assertion or claim, whether written or oral, regarding the accounting or auditing practices, procedures, methodologies or methods of the Company or any of its Subsidiaries or
their respective internal accounting controls, including any material complaint, allegation, assertion or claim that the Company has engaged in questionable accounting or auditing practices, and (ii) to the Company’s knowledge, no attorney
representing the Company or any of its Subsidiaries, whether or not employed by the Company or any of its Subsidiaries, has reported evidence of a material violation of securities laws, breach of fiduciary duty or similar violation by the Company or
any of its officers, directors, employees or agents to the Board or any committee thereof or to any director or officer of the Company. 

3.8. Absence of Certain Developments. 

Since December 31, 2013, (a) the Company and the Medical JV have conducted, in all material respects, their businesses in the
ordinary course, consistent with past practice, (b) there has not been a Material Adverse Effect, and (c) there has not been (i) any declaration, setting aside or payment of any dividend or other distribution (whether in cash, stock
or property) with respect to any of the Company’s outstanding securities or any repurchase or redemption by the Company or the Medical JV of any such securities, (ii) any change in accounting methods, principles or practices by the Company
or the Medical JV materially affecting its assets or liabilities, except insofar as may have been required by law or by a change in applicable GAAP, (iii) any sales, pledges, dispositions, transfers, leases, exclusive licenses, guarantees or
encumbrances of any material property or assets of the Company or the Medical JV outside the ordinary course of business, (iv) any material acquisition (including, without limitation, by merger, consolidation, or acquisition of stock or assets
or any other business combination) by the Company or the Medical JV of any corporation, partnership, other business organization or any division thereof, (v) to the knowledge of the Company, any unauthorized disclosure of any material trade
secrets of the Company or the Medical JV, (vi) any incurrence by the Company or the Medical JV of indebtedness for borrowed money which, individually or together with all such other indebtedness, exceeds $500,000, (vii) grants of any
material security interest in any material assets of the Company or the Medical JV, (viii) any capital expenditure or purchase of fixed assets by the Company or the Medical JV other than in the ordinary course of business consistent with past
practice or in accordance with the Company’s capital expenditure budget as approved by the Board, (ix) any change by the Company or the Medical JV of any material election in respect of taxes, any adoption or change by the Company or the
Medical JV of any material accounting method in respect of taxes or settlement or compromise by the Company or any of its Subsidiaries of any material claim, notice, audit report or assessment in respect of taxes, (x) any pre-payment of any
long-term debt or payment, discharge or satisfaction of any claims, liabilities or obligations (absolute, accrued, contingent or otherwise) by the Company or the Medical JV, except for such payments, discharges or satisfaction of claims as were made
or effected in the ordinary course of business consistent with past practice, (xi) any write-up, write-down or write-off of the book value of any material assets, or a material amount of any other assets, of the Company or the Medical JV, other
than as required by GAAP or (xii) any change in the Board or the officers of the Company. 

  
 - 7 - 

 3.9. Compliance. 

(a) Neither the Company nor the Medical JV is, nor since December 31, 2010 has been, in violation or default under its Organizational
Documents. 
 (b) Neither the Company nor the Medical JV is, nor since December 31, 2010 has been, in material violation of any laws,
ordinances, governmental rules or regulations to which it is subject, including, without limitation, laws or regulations relating to the environment or to occupational health and safety, and no material expenditures are or will be
required in order to cause its current operations or properties to comply with any such law, ordinances, governmental rules or regulations. 

(c) Neither the Company nor the Medical JV has knowledge of any actual or threatened enforcement action or investigation by the FDA or any
other Governmental Authority that has jurisdiction over the operations of the Company and its Subsidiaries. Neither the Company nor any of its Subsidiaries has any knowledge that the FDA or any other Governmental Authority is considering such
action. 
 (d) The Company and the Medical JV have, and since December 31, 2010 have had, all licenses, permits, franchises or other
governmental authorizations (“Permits”) necessary for the ownership of their property or for the conduct of their respective businesses other than for those separately discussed in Section 3.34 of this Agreement, which if
violated or not obtained would reasonably be expected to have a Material Adverse Effect (collectively the “Material Licenses”); and all such Material Licenses are in full force and effect and, to the knowledge of the Company, no
material suspension or cancellation of any of them is threatened, and all such filings, applications and registrations with respect to the Material Licenses are current. Neither the Company nor the Medical JV has finally been denied any application
for any such Material Licenses. 
 (e) No Permit issued to the Company or the Medical JV by the FDA or any other Governmental Authority has,
since December 31, 2010, been limited, suspended, modified or revoked and the Company has no knowledge or reason to believe that the FDA or any other Governmental Authority is considering such action. 

(f) The Company is, and since December 31, 2010 have been, in compliance in all material respects with the applicable provisions of the
Sarbanes-Oxley Act. Neither the Company nor any of its Affiliates has made, arranged or modified (in any material way) personal loans to any executive officer or director of the Company and no such loans are outstanding as of the date hereof. 

  
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 3.10. Litigation. 

There are no claims, actions, suits, inquiries, judicial or administrative proceedings or arbitrations pending or, to the knowledge of the
Company, threatened against the Company, the Medical JV or any of their respective assets by or before any arbitrator or Governmental Authority, nor are there any reviews or investigations relating to the Company, the Medical JV or any of their
respective assets pending, or to the knowledge of the Company, threatened by or before any arbitrator or Governmental Authority, except in each case as would not reasonably be expected to have a Material Adverse Effect. 

3.11. Absence of Undisclosed Liabilities. 

Neither the Company nor the Medical JV has any debt, obligation or liability (whether accrued, absolute, contingent, liquidated or otherwise,
whether due or to become due, whether or not known to the Company) arising out of any transaction entered into at or prior to the Closing, or any act or omission at or prior to the Closing, or any state of facts existing at or prior to the Closing,
including taxes with respect to or based upon the transactions or events occurring at or prior to the Closing, and including, without limitation, unfunded past service liabilities under any pension, profit sharing or similar plan,
except for (a) liabilities disclosed in the financial statements included in the Reference SEC Reports, (b) liabilities incurred in the usual and ordinary course of business consistent with past practice subsequent to December 31,
2013 and (c) liabilities that have not had and would not reasonably be expected to have a Material Adverse Effect. 
 3.12. Change in
Ownership.  
 (a) Neither (i) the issuance of the Securities to the Purchasers nor (ii) the consummation of the
transactions contemplated by this Agreement and the Transaction Documents will result in (A) the acceleration of the vesting of any outstanding option, warrant, call, commitment, agreement (including employment agreements), conversion right,
preemptive right or other right to subscribe for, purchase or otherwise acquire any of the shares of the capital stock of the Company or the Medical JV, or debt securities, credit agreements or other debt instruments of the Company or the Medical JV
(collectively “Commitments”, and each individually a “Commitment”), (B) any obligation of the Company to grant, extend or enter into any Commitment other than as contemplated by this Agreement or the
Transaction Documents, or (C) any right in favor of any other Person to terminate or cancel any Material Closing Date Contract. 
 3.13.
Employment Matters.  
 (a) The Company is not bound by or subject to (and none of its assets or properties is bound by or
subject to) any written or oral, express or implied, Contract, commitment or arrangement with any employee, consultant or Director other than as listed on Schedule 3.13(a). The Company and the Medical JV are in material compliance with all
federal, state, local and foreign laws and regulations respecting employment and employment practices, terms and conditions of employment and wages and hours, as applicable. Neither the Company nor the Medical JV is bound by or subject to (and none
of its assets or properties is bound by or subject to) any written or oral, express or implied, Contract, commitment or arrangement with any labor union, and since December 31, 2010 no labor union has requested or, to the Company’s
knowledge, has sought to represent any of the employees, representatives or agents of the Company or the Medical JV. There is no strike or other labor dispute involving the Company or the Medical JV pending, or to the Company’s knowledge,
threatened nor is the Company aware of any labor organization activity involving its employees. The Company is not aware that any executive officer or key employee, intends to terminate their employment with the Company or the Medical JV, nor does
the Company have a present intention to terminate the employment of any of the foregoing. 

  
 - 9 - 

 (b) All material employee benefit plans covering current or former officers, directors,
employees of the Company or the Medical JV or current or former independent contractors or consultants of the Company or the Medical JV, or under which there is a financial obligation of the Company or the Medical JV, including, but not limited to,
“employee benefit plans” within the meaning of Section 3(3) of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), whether or not subject to ERISA, and deferred compensation, stock option, stock
purchase, stock appreciation rights, other stock or stock-based, incentive and bonus, employment, retention, consulting, change in control, salary continuation, termination or severance plan, program, policy, practice, arrangement or agreement (the
“Company Benefits Plans”), have been established and administered in accordance with their respective terms, and in compliance in all material respects with the applicable provisions of ERISA, the Code and other applicable laws. All
contributions (including all employer contributions and employee salary reduction contributions) required to have been made under any of the Company Benefit Plans to any funds or trusts established thereunder or in connection therewith have been
made by the due date thereof. 
 (c) Except for such matters that would not, individually or in the aggregate, be reasonably expected to
have a Material Adverse Effect: 
 (1) neither the Company nor the Medical JV has engaged in a transaction that, assuming the
taxable period of such transaction expired as of the date hereof, could subject the Company or the Medical JV to a tax or penalty imposed by either Section 4975 of the Code or Section 502(i) of ERISA or any other similar provision of
non-U.S. law; 
 (2) neither the Company nor the Medical JV has or is expected to incur any liability under Title IV of ERISA
with respect to any “single-employer plan”, within the meaning of Section 4001(a)(15) of ERISA, any Multiemployer Plan or any “multiple employer plan”, within the meaning of Section 4063/4064 of ERISA or
Section 413(c) of the Code, in each case currently or formerly maintained or contributed to by any of them or any other entity which is considered one employer with the Company under Section 4001 of ERISA or Section 414 of the Code
(an “ERISA Affiliate”); and 
 (3) none of the Company, the Medical JV or any ERISA Affiliate have any
unsatisfied withdrawal liability with respect to a Multiemployer Plan under Subtitle E of Title IV of ERISA. 

  
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 3.14. Tax Matters. 

(a) All material tax returns required to be filed by, or with respect to, the Company or the Medical JV have been timely filed (taking into
account extensions) and are correct and complete in all material respects. The Company and the Medical JV have timely paid all taxes due and payable by it or for which it may be liable (other than taxes that are being contested in good faith and for
which adequate reserves are reflected in accordance with GAAP). The Company and the Medical JV have made adequate provision in accordance with GAAP on their respective balance sheet for all taxes payable for which no tax return has yet been filed.

 (b) Since December 31, 2010, none of the Company or the Medical JV has incurred any liability for material taxes outside the
ordinary course of business consistent with past practice. 
 (c) To the Company’s knowledge, no examination or audit of any tax return
relating to any material taxes of the Company or the Medical JV or with respect to any material taxes due from or with respect to the Company or the Medical JV by the Internal Revenue Service or the appropriate state, local or foreign taxing
authority is currently in progress, and no assessment of material tax has been proposed in writing against the Company or its Subsidiaries or any of their assets or properties. 

(d) Neither the Company nor the Medical JV has any current material liability for taxes of any person (other than the Company and the Medical
JV) (A) under Treasury Regulations Section 1.1502-6 (or any similar provision of state, local or foreign law), (B) as a transferee or successor or (C) by Contract. 

(e) None of the Company or the Medical JV is a party to, is bound by or has any obligation under any tax sharing or tax indemnity contract or
similar arrangement. 
 (f) Neither the Company nor the Medical JV has been a party to a “reportable transaction”, as such term is
defined in Treasury Regulations Section 1.6011-4(b)(1) or to a transaction that is or is substantially similar to a “listed transaction”, as such term is defined in Treasury Regulations Section 1.6011-4(b)(2). 

3.15. Contracts 
 (a)
Except for this Agreement and the Transaction Documents and such Contracts as are listed on Schedule 3.15(a) or are filed, incorporated by reference or referenced as exhibits to (x) the Company’s Annual Report on Form 10-K for the
year ended December 31, 2013 or (y) any Company SEC Reports filed with the SEC after January 1, 2014 (collectively, the “Material Signing Date Contracts”), neither the Company nor the Medical JV is a party to or bound
as of the date of this Agreement by any: 
 (i) mortgage, indenture, note, or installment obligation, or other instrument
for or relating to any material amount of indebtedness; 
 (ii) Contract pursuant to which it is or may be obligated to make
payments in excess of $25,000 individually or $50,000 in the aggregate, contingent or otherwise, on account of or arising out of prior acquisitions or sales of businesses, assets, or stock of other companies; 

  
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 (iii) Contract imposing non-competition obligations on the Company or the
Medical JV; 
 (iv) Contract providing for expected payments to or by any other Person based on sales, purchases, or profits
in excess of $50,000 individually, other than direct payments for goods; 
 (v) Contract providing for any milestone or
similar payments; 
 (vi) Contract or agreement for the employment of any director, executive officer or consultant not
terminable without penalty or liability arising from such termination or containing any severance, or change of control provisions or any analogous Contract or arrangement; 

(vii) Contract relating to cleanup, abatement or other actions in connection with any environmental liability under any
Environmental Laws; 
 (viii) collective bargaining agreement or other Contract to or with any labor union or other
representative of a group of employees; 
 (ix) Contract which contains restrictions with respect to payment of dividends or
any other distribution in respect of the capital stock or other equity interests of the Company or the Medical JV; 
 (x)
Contract relating to capital expenditures or other purchases of material, supplies, equipment (including all Contracts to purchase containers, trailers or portable offices) or other assets or properties in excess of $25,000 individually, or $50,000
per counterparty in any year; 
 (xi) Contract involving a loan (other than accounts receivable from trade debtors in the
ordinary course of business) or advance to (other than expense allowances to the employees of the Company or the Medical JV extended in the ordinary course of business), or investment in, any Person or any Contract relating to the making of any such
loan, advance or investment; 
 (xii) Contract granting or evidencing a Lien on any properties or assets of the Company or
the Medical JV other than equipment leases in the ordinary course of business; 
 (xiii) management service, consulting,
financial advisory or any other similar type Contract, other than revenue-based commission agreements, in each case obligating the Company or the Medical JV to pay in excess of $25,000 in any consecutive 12-month period, or any Contract with any
investment or commercial bank (other than standard deposit account Contracts); 

  
 - 12 - 

 (xiv) Contract (other than this Agreement and any agreement or instrument
entered into pursuant to this Agreement) with (A) any Affiliate of the Company or the Medical JV or (B) any current or former officer or director of the Company or the Medical JV; 

(xv) Contract involving the present or future disposition or acquisition of material assets or properties (other than
inventory in the ordinary course of business), or any merger, consolidation or similar business combination transaction; 

(xvi) Contract providing any Person with the right of first refusal or first offer or similar type provision with respect to
the disposition or acquisition of any assets other than sales of non-material assets in the ordinary course of business; 

(xvii) Contract involving any material joint venture, partnership, strategic alliance, shareholders’ agreement,
co-marketing, co-promotion, co-packaging, joint development or similar arrangement; 
 (xviii) Contract since
December 31, 2008 involving any material resolution or settlement of any actual or threatened litigation, arbitration, claim or other dispute; 

(xix) Contract involving an obligation of standstill on the part of the Company or the Medical JV or similar agreement or
arrangement in connection with a potential merger or material acquisition or disposition of a business; 
 (xx) lease to
which the Company or the Medical JV is a party (as lessee or lessor) and involving a quarterly base rental payment in excess of $25,000 per lease; 

(xxi) Contract material to the Company’s or the Medical JV’s business which provides for termination, acceleration
or other similar rights or any other consideration of any kind with respect to any direct or indirect change of control of the Company or the Medical JV; 

(xxii) material Contract which provides for termination, acceleration or other similar material rights or any other material
consideration of any kind with respect to any direct or indirect change of control of the Company or the Medical JV; 

(xxiii) Contract entered into outside the ordinary course of business and pursuant to which the Company or the Medical JV is
obligated to indemnify any Person; 

  
 - 13 - 

 (xxiv) material Contract relating to Company Intellectual Property; 

(xxv) “material contract” (as such term is defined in Item 601(b)(10) of Regulation S-K of the SEC) not listed
above; or 
 (xxvi) Contract not listed above that is otherwise material to the business of the Company and the Medical JV
taken as a whole. 
 (b) (i) As of the date of this Agreement: (x) each Material Signing Date Contract is valid, binding and
enforceable against the Company or the Medical JV, as applicable, and to the Company’s knowledge, the other parties thereto in accordance with its terms, and is in full force and effect; (y) the Company or the Medical JV, as applicable,
has performed all material obligations required to be performed by it to date under each Material Signing Date Contract; and (z) neither the Company nor the Medical JV, as applicable, nor, to the knowledge of the Company, any other party
thereto, is in material breach of or default under any Material Signing Date Contract, and to the knowledge of the Company, no event has occurred which, with due notice or lapse of time or both, would reasonably be expected to constitute such a
breach. (ii) As of each Closing Date: (x) each Contract in existence as of such Closing Date of a type described in Sections 3.15(a)(i)—(xxvi) (the “Material Closing Date Contracts”) is valid, binding and
enforceable against the Company or the Medical JV, as applicable, and to the knowledge of the Company, the other parties thereto in accordance with its terms, and is in full force and effect; (y) the Company or the Medical JV, as applicable,
has performed all material obligations required to be performed by it on or prior to the applicable Closing Date under each Material Closing Date Contract; and (z) neither the Company nor the Medical JV, as applicable, nor, to the knowledge of
the Company, any other party thereto, is in material breach of or default under any Material Closing Date Contract, and to the knowledge of the Company, no event has occurred which, with due notice or lapse of time or both, would reasonably be
expected to constitute such a breach. 
 (c) The Company has delivered or otherwise made available to the Purchasers a true and correct copy
of each Material Signing Date Contract. 
 (d) The Company has delivered or otherwise made available to the Purchasers a true and correct
list of all material milestone or similar payments owed by the Company as of the date hereof under any Contract, including the amount of such payments, the events triggering such payments and the Company’s good faith estimate as to the timing
of such payments. 
 3.16. Intellectual Property. 

(a) Schedule 3.16 of the Company Disclosure Letter sets forth a complete and correct list of all trademark and patent registrations and
applications for trademark and patent registration owned by the Company or the Medical JV as of the date hereof, all of which registrations are valid, enforceable and in full force and effect. 

  
 - 14 - 

 (b) (i) The Company and the Medical JV own solely and exclusively or have the right to use
pursuant to a valid license, all of the Intellectual Property owned, used or held for use in the business of the Company or the Medical JV (“Company Intellectual Property”), (ii) to the Company’s knowledge, the Company
Intellectual Property is all of the Intellectual Property necessary for the conduct of the respective businesses of the Company and the Medical JV as currently conducted, (iii) the Company and the Medical JV have taken commercially reasonable
measures to preserve, maintain and protect the Company Intellectual Property, (iv) the execution and delivery of this Agreement and the consummation of the transactions contemplated by this Agreement will not alter, encumber, impair or
extinguish any Company Intellectual Property, (v) to the Company’s knowledge, none of the Company’s or the Medical JV’s material trade secrets have been disclosed to any Person in an unauthorized manner, and (vi) the Company
will not be, as a result of the execution and delivery of this Agreement or any Transaction Document, or the performance of the Company’s obligations under this Agreement or any Transaction Document, in breach of any license, sublicense or
other agreement relating to any Company Intellectual Property and, to the knowledge of the Company, no event has occurred which, with due notice or lapse of time or both, would reasonably be expected to constitute such a breach. 

(c) To the knowledge of the Company, neither the Company Intellectual Property nor the conduct of the business of the Company or the Medical
JV has interfered with, infringed upon, misappropriated or otherwise violated, or is interfering with, infringing upon, misappropriating or otherwise violating, any Intellectual Property rights of third parties in any material respect, and, to the
knowledge of the Company, no third party has interfered with, infringed upon, misappropriated or otherwise violated, or is interfering with, infringing upon, misappropriating or otherwise violating in any material respect, any Company Intellectual
Property owned by the Company or the Medical JV. 
 (d) Neither the Company nor the Medical JV has been named in any pending suit, action or
proceeding which involves a claim of infringement, violation, misrepresentation, misappropriation or misuse of any Intellectual Property right of any third party, and to the knowledge of the Company is not threatened to be named in any such suit,
action or proceeding. 
 (e) No third party, including but not limited to the Medical JV, has any right(s) or option(s) to exercise rights
related to Company Intellectual Property and/or Intellectual Property to be developed as part of any Contract listed on Schedule 3.15(a), other than the right(s) and option(s) specifically enumerated on Schedule 3.16(e). The Company hereby
represents: (i) that Schedule 3.16(e) constitutes an accurate, current, and complete listing of all such right(s) and option(s); (ii) that the Company has provided Purchasers with all documentation related to such right(s) and
option(s) necessary for Purchasers to determine the subject matter and scope of such right(s) and option(s); and (iii) that any breach of this representation by the Company shall constitute a material breach of this Agreement. 

  
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 3.17. Insurance. 

The Company and the Medical JV and their respective properties are insured in such amounts, against such losses and with such insurers as are
consistent with what would reasonably be expected in light of the nature of the properties and businesses of the Company and the Medical JV. A copy of the Company’s director and officer liability insurance policy has been provided or otherwise
made available to the Purchasers. Such policy is in full force and effect, the Company is current in the payment of all fees related thereto, the Company has not received any notice of cancellation in connection therewith and, to the knowledge of
the Company, no action has been taken that would result in the cancellation or termination of such policy. 
 3.18. Environmental
Liability. 
 Except for matters that, individually or in the aggregate, would not reasonably be expected to have a Material Adverse
Effect, (i) the Company and the Medical JV are and have been in compliance with all applicable Environmental Laws and have obtained or applied for all Environmental Permits necessary for their operations as currently conducted; (ii) there
have been no Releases of any Hazardous Materials that could be reasonably likely to form the basis of any Environmental Claim against the Company or the Medical JV; (iii) there are no Environmental Claims pending or, to the knowledge of the
Company, threatened against the Company or the Medical JV; (iv) neither the Company nor the Medical JV is subject to any agreement, order, judgment, decree, letter or memorandum by or with any Governmental Authority or third party imposing any
liability or obligation under any Environmental Law; and (v) neither the Company nor the Medical JV has retained or assumed, either contractually or by operation of law, any liability or obligation that could reasonably be expected to form the
basis of any Environmental Claim against the Company or the Medical JV. 
 3.19. Transactions with Related Parties. 

Except for this Agreement and the Transaction Documents, as of the date hereof, there are no transactions, or series of related transactions,
agreements, arrangements or understandings, nor are there any currently proposed material transactions, or series of related transactions, between the Company or the Medical JV, on the one hand, and the Company, the Medical JV, any current or former
director, officer, partner, employee or Affiliate of the Company or the Medical JV, on the other hand, that would be required to be disclosed under Item 404 of Regulation S-K promulgated under the Securities Act and that has not been properly
disclosed. 
 3.20. Property. 

The Company and the Medical JV have good and marketable fee simple title to or valid leasehold interests in all of the real property owned or
leased by the Company or the Medical JV and good title to, or valid leasehold interests in, all of their personal property, except where the failure to hold such title or leasehold interests, individually or in the aggregate, is not reasonably
expected to have a Material Adverse Effect. The Company and the Medical JV enjoy peaceful and undisturbed possession under all of their respective leases except where the failure to enjoy such peaceful and undisturbed possession, individually or in
the aggregate, is not reasonably expected to have a Material Adverse Effect. 

  
 - 16 - 

 3.21. Indebtedness. 

Except as set forth on Schedule 3.21, neither the Company nor the Medical JV has any outstanding Indebtedness. 

3.22. Accuracy of Information. 

All factual information furnished by or on behalf of the Company and the Medical JV in writing to the Purchasers on or prior to the date of
this Agreement, for purposes of this Agreement and all other such factual information furnished by the Company on behalf of itself and the Medical JV in writing to the Purchasers pursuant to the terms of this Agreement was and will be, true and
accurate in all material respects in the aggregate on the date as of which such information is dated or furnished and not incomplete by knowingly omitting to state any material fact necessary to make such information not misleading at such time in
light of the circumstances under which such information was provided, provided, however, that with respect to any projected financial information or forward-looking statements, business assumptions, strategic plans or similar information, the
Company represents only that such information was prepared in good faith based upon assumptions, and subject to such qualifications, believed to be reasonable at the time. The Company makes no representation in this Section 3.22 with
respect to any information to the extent prepared by third parties. 
 3.23. Registration Rights; Voting Rights.  

Except as required by this Agreement and the Registration Rights Agreement, (a) the Company will not, as of the date hereof, be under any
obligation to register any of its securities under the Securities Act, except for any continuing obligations of the Company to maintain previously filed registration statements, and (b) to the knowledge of the Company, no shareholder of the
Company has entered into any agreement with respect to the voting of equity securities of the Company. 
 3.24. Private Offering. 

(a) Assuming the truth and accuracy of the representations and warranties of the Purchasers set forth in Section 4 of this
Agreement, the offer, issuance and sale of the Securities are and will be exempt from the registration requirements of the Securities Act. Neither the Company nor any Person acting on its behalf has conducted any general solicitation or general
advertising (as those terms are used in Regulation D) in connection with the offer or sale of any of the Securities. 
 (b) None of the
Company, any of its predecessors, any affiliated issuer, any director, executive officer, other officer of the Company participating in the offer and sale of the Securities, any beneficial owner of 20% or more of the Company’s outstanding
voting equity securities, calculated on the basis of voting power, nor any promoter (as that term is defined in Rule 405 under the Securities Act) connected with the Company in any capacity at the time of sale (each, an “Issuer Covered
Person” and, together, “Issuer Covered Persons”) is subject to any of the “Bad Actor” disqualifications described in Rule 506(d)(1)(i) to (viii) under the Securities Act (a “Disqualification
Event”), except for a Disqualification Event covered by Rule 506(d)(2) or (d)(3). The Company has exercised reasonable care to determine whether any Issuer Covered Person is subject to a Disqualification Event. 

  
 - 17 - 

 3.25. Investment Banking. 

Except as otherwise set forth on Schedule 3.25, there are no claims for investment banking fees or similar compensation in connection
with the transactions contemplated by this Agreement or the Transaction Documents based on any arrangement made by or on behalf of the Company. 

3.26. Takeover Provision. 

The Company has taken all necessary actions such that the restrictions on business combinations set forth in Section 203 of the DGCL do
not and will not apply to the Purchasers, this Agreement or the Transaction Documents or to any of the transactions contemplated hereby or thereby by the approval of the foregoing in accordance with Section 203(a)(1) of the DGCL. No other
Takeover Provision is applicable to the transactions contemplated hereby. There are (i) no anti-takeover provision in the Organizational Documents of the Company or other similar organizational documents of its Subsidiaries, and (ii) no
shareholder rights plan, “poison pill” or similar measures applicable to the Company. 
 3.27. Miscellaneous Securities Law
Matters. 
 The Common Stock is registered pursuant to Section 12(g) of the Exchange Act and the Company has taken no action
designed to terminate, or to the Company’s knowledge likely to have the effect of terminating, the registration of the Common Stock under the Exchange Act, nor has the Company received any notification that the SEC is contemplating terminating
such registration. The Company has not taken and will not take, and to the knowledge of the Company no Person acting on its behalf has taken, in violation of applicable law, any action designed to or that might reasonably be expected to cause or
result in unlawful manipulation of the price of the Common Stock. 
 3.28. Accountants 

Baker Tilly Virchow Krause, LLP, who have audited certain financial statements included the Company’s Reference SEC Reports, is an
independent registered public accounting firm within the meaning of Article 2-01 of Regulation S-X and the Public Company Accounting Oversight Board (United States). 

3.29. [Reserved.] 
 3.30. No
Integrated Offering. 
 Assuming the truth and accuracy of the representations and warranties of the Purchasers in this Agreement,
neither the Company nor any of its Affiliates, nor any Person acting on its or their behalf has, directly or indirectly, made any offers or sales of any Company security or solicited any offers to buy any security, under circumstances that would
adversely affect reliance by the Company on Section 4(2) or Rule 506 of Regulation D for the exemption from registration for the transactions contemplated hereby or would require registration of the Securities under the 1933 Act. 

  
 - 18 - 

 3.31. Questionable Payments. 

Neither the Company nor the Medical JV nor, to knowledge of the Company, any of their respective current or former stockholders, directors,
officers, employees, agents or other Persons acting on behalf of the Company or the Medical JV, has on behalf of the Company or the Medical JV or in connection with their respective businesses: (a) used any corporate funds for unlawful
contributions, gifts, entertainment or other unlawful expenses relating to political activity; (b) made any direct or indirect unlawful payments to any governmental officials or employees from corporate funds; (c) established or maintained
any unlawful or unrecorded fund of corporate monies or other assets; (d) made any false or fictitious entries on the books and records of the Company or the Medical JV; or (e) made any unlawful bribe, rebate, payoff, influence payment,
kickback or other unlawful payment of any nature. 
 3.32. Suppliers. 

To the knowledge of the Company, there are no facts concerning its material suppliers that would reasonably be expected to result in any
material interruption (whether due to a regulatory, including without limitation, customs, manufacturing, intellectual property or any other issue) of the timely supply by such suppliers to the Company and the Medical JV of any such materials. No
such supplier has notified the Company or the Medical JV in writing that it intends to terminate or materially alter the terms of its relationship with the Company or the Medical JV. 

3.33. Product Liability. 

No product liability claims have been asserted in writing against the Company or the Medical JV or, to the knowledge of the Company, threatened
against the Company or the Medical JV relating to any of their products or product candidates developed, tested, manufactured, marketed, distributed or sold by the Company or the Medical JV, except for claims that, individually or in the aggregate,
are not reasonably likely to have a Material Adverse Effect. There is no material judgment, order or decree outstanding against the Company or the Medical JV relating to product liability claims or assessments. 

3.34. FDA and Related Matters. 

(a) Each product or, except as set forth on Schedule 3.34(a), product candidate subject to the Federal Food, Drug and Cosmetic Act
(including the rules and regulations of the FDA promulgated thereunder, the “FDCA”) or comparable Laws in any non-U.S. jurisdiction that has been developed, manufactured, tested, distributed, promoted or marketed by or on behalf of
the Company or the Medical JV (each such product or product candidate, a “Company Product”), is being or has been designed, developed, manufactured, investigated, tested, assembled, packaged, labeled, stored, serviced, distributed,
promoted and marketed in material compliance with all applicable requirements under the FDCA, all applicable state and local laws, and comparable laws in any applicable non-U.S. jurisdiction, including those relating to investigational use,
premarket clearance or approval, registration and listing, good manufacturing practices, good clinical practices, good laboratory practices, labeling, advertising, data protection and data transfer, record keeping and filing of required
reports. The Company and the Medical JV maintain accurate and complete documentation, including documentation relating to supplier auditing and inspection and testing of incoming components, showing that components supplied to the Company or
the Medical JV are manufactured in accordance with the Company’s and the Medical JV’s specifications therefor. 

  
 - 19 - 

 (b) In connection with the Company Products: (i) the Company and the Medical JV and, to the
knowledge of the Company, the Company Partners have filed with the applicable regulatory authorities (including, without limitation, FDA or any foreign, federal, state or local governmental or regulatory authority performing functions similar to
those performed by the FDA) any required material filing, declaration, listing, registration, report or submission; (ii) all such material filings, declarations, listings, registrations, reports or submissions were in material compliance with
applicable laws when filed; and (iii) except as set forth on Schedule 3.34(b), no deficiencies have been asserted by any applicable regulatory authority (including, without limitation, the FDA or any foreign, federal, state or local
governmental or regulatory authority performing functions similar to those performed by the FDA) with respect to any such filings, declarations, listings, registrations, reports or submissions that remain unresolved. Neither the Company nor the
Medical JV, nor any employee of the Company or the Medical JV, nor to the knowledge of the Company or the Medical JV, any Person retained by the Company or the Medical JV has made on behalf of the Company or the Medical JV any false statements or
material omissions in any application or other submission relating to the products or product candidates to the FDA or other Governmental Entity. 

(c) To the Company’s and the Medical JV’s knowledge, with regard to the Company Products, all of the manufacturing facilities and
operations of the Company and the Medical JV are in compliance in all material respects with applicable FDA and comparable regulations in any applicable non-U.S. jurisdiction, including current Good Manufacturing Practices. 

(d) To the Company’s and the Medical JV’s knowledge, there are no existing circumstances which would furnish a basis for an action
by FDA or any other Governmental Authority to revoke, suspend, cancel, modify or withdraw any product approval, clearance, license, clinical trial, investigation, registration, or other Material License with respect to any of the Company Products,
and the Company and Medical JV are not aware of any of the foregoing having occurred. 
 (e) There is no civil, criminal or administrative
action, suit, demand, claim, complaint, hearing, notice, demand letter, warning letter, proceeding or request for information pending, or to the Company’s or the Medical JV’s knowledge threatened, nor to the Company’s or the Medical
JV’s knowledge any investigation or inquiry pending or threatened, against the Company or the Medical JV, and neither the Company nor the Medical JV has any liability (whether actual or contingent) for failure to comply with any applicable laws
and regulations. Neither the Company nor the Medical JV has received any notice or written communication from the FDA alleging material noncompliance with the FDCA. Neither the Company nor the Medical JV has received any written notice that the FDA
or any other Governmental Authority has commenced, or threatened to initiate, any action to (i) withdraw its investigational device exemption, premarket clearance or premarket approval, or request the recall of any Company Product,
(ii) enjoin manufacture or distribution of any Company Product, or restrict the promotion of any Company Product in the manner currently conducted by the Company and the Medical JV, (iii) enjoin the manufacture or distribution of any
Company Product produced at any facility where any Company Product is manufactured, tested, processed, packaged, stored, or held for sale, or (iv) investigate the Company or its products or its practices related thereto. 

  
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 (f) The Company and the Medical JV have not either voluntarily or involuntarily initiated,
conducted or issued, or caused to be initiated, conducted or issued, any recall, field notification, field correction, market withdrawal or replacement, safety alert, warning, “dear doctor” letter, investigator notice, or other notice or
action relating to an alleged lack of safety, effectiveness or regulatory compliance of any product that remains unresolved. The Company and the Medical JV are not aware of any facts which are reasonably likely to cause (1) the recall,
market withdrawal or replacement of any product currently sold or intended to be sold by the Company or the Medical JV; (2) a change in the marketing classification or a material change in the labeling of any such products, or (3) a
termination or suspension of the marketing of such products. 
 (g) Neither the Company nor the Medical JV, nor any employee of the Company
or the Medical JV, nor to the knowledge of the Company or the Medical JV, any Person retained by the Company or the Medical JV has made on behalf of the Company or the Medical JV any false statements or material omissions in any application or other
submission relating to the Company Products to the FDA or other Governmental Authority. 
 (h) Neither the Company nor the Medical JV, nor
to the knowledge of the Company or the Medical JV, any of its respective officers, directors, employees, agents or contractors (i) has been excluded or debarred from any federal healthcare program (including without limitation Medicare or
Medicaid) or any other federal program; or (ii) has received written notice from the FDA with respect to debarment or disqualification. Neither the Company nor the Medical JV has ever been, or is now subject to, FDA’s Applications
Integrity Policy. 
 (i) The Company and the Medical JV have provided or otherwise made available to Purchasers a copy of all of the
following since December 31, 2010 (i) FDA or its foreign equivalent inspection reports, (ii) notices of adverse findings, (iii) warning, untitled letters, minutes of meetings or any other verbal, written, or electronic
correspondence or communication from the FDA or other Governmental Authorities concerning the Company Products in which FDA or such other Governmental Authority asserted that the operations, products or product candidates of the Company or the
Medical JV or any Company Partner may not be in compliance with applicable laws. 
 SECTION 4. REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS 

Each of the Purchasers represents and warrants, severally and not jointly, to the Company as of the date hereof and each Closing Date (except
to the extent made only as of specified date, in which case as of such date) as follows: 
 (a) It is acquiring the Securities for its own
account for investment and not with a view towards the resale, transfer or distribution thereof, nor with any present intention of distributing the Securities but subject, nevertheless, to any requirement of law that the disposition of such
Purchaser’s property shall at all times be within such Purchaser’s control, and without prejudice to such Purchaser’s right at all times to sell or otherwise dispose of all or any part of such securities under a registration under the
Securities Act or under an exemption from said registration available under the Securities Act. 

  
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 (b) It has full power and legal right to execute and deliver this Agreement and the Transaction
Documents to which it is a party and to perform its obligations hereunder and thereunder. 
 (c) As of the date hereof, it is a resident of
the jurisdiction set forth immediately below such Purchaser’s name on the signature pages hereto. 
 (d) It has taken all action
necessary for the authorization, execution, delivery, and performance of this Agreement and the Transaction Documents to which it is a party and its obligations hereunder and thereunder, and, upon execution and delivery by the Company, this
Agreement and the Transaction Documents to which it is a party shall constitute the valid and binding obligation of such Purchaser, enforceable against such Purchaser in accordance with their respective terms, except that such enforcement may be
limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws now or hereafter in effect relating to creditors’ rights and general principles of equity. 

(e) It has such knowledge and experience in financial and business matters that it is capable of evaluating the merits and risks of its
investment in the Company as contemplated by this Agreement and the Transaction Documents to which it is a party, and is able to bear the economic risk of such investment for an indefinite period of time. It has been furnished access to such
information and documents as it has requested and has been afforded an opportunity to ask questions of and receive answers from representatives of the Company concerning the terms and conditions of this Agreement and the Transaction Documents to
which it is a party and the purchase of the Securities contemplated hereby. Either (i) each Purchaser is an “accredited investor” within the meaning of Rule 501 of Regulation D under the Securities Act or (ii) if a Purchaser has
been formed for the purposes of the transactions contemplated by this Agreement, such Purchaser reasonably believes that its shareholders satisfy the requirements to be “accredited investors” within the meaning of Rule 501 of Regulation D
under the Securities Act. 
 (f) Such Purchaser is not purchasing the Securities as a result of any advertisement, article, notice or other
communication regarding the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented at any seminar or any other general advertisement. 

(g) It understands that no United States federal or state agency or any other government or governmental agency has passed upon or made any
recommendation or endorsement of the Securities or an investment therein. 

  
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 SECTION 5. ADDITIONAL AGREEMENTS OF THE PARTIES 

5.1. Preemptive Rights 

(a) If the Company at any time or from time to time makes a Subject Equity Offering, each Purchaser that holds any shares of Series A
Preferred Stock at such time shall be afforded the opportunity to acquire from the Company, for the same price and on the same terms as New Equity Securities are proposed to be offered to others, in the aggregate up to that amount of New Equity
Securities equal to (i) the total amount of New Equity Securities being offered in such Subject Equity Offering multiplied by a fraction, the numerator of which is (A) the sum (without duplication) of (x) number of shares of Common
Stock held by such Purchaser immediately prior to such Subject Equity Offering, (y) a number of shares of Common Stock equal to the product of the number of shares of Series A Preferred Stock held by such Purchaser multiplied by the quotient of
(A) the Stated Value (as defined in the Certificate of Designation) divided by (B) the Optional Conversion Price (as defined in the Certificate of Designation) and (z) all shares of Common Stock that such Purchaser has the right to
acquire or receive upon exercise or conversion of all other Company securities exercisable for and/or convertible into Common Stock then held by such Purchaser, and the denominator of which is (B) the total number of shares of Common Stock then
outstanding, on a Fully Diluted Basis. 
 (b) (i) In the event the Company intends to make a Subject Equity Offering that is an underwritten
public offering, no later than five (5) Business Days prior to (x) the initial filing of a registration statement with the SEC with respect to such underwritten public offering or (y) in the case of an offering relating to an existing
“shelf” registration statement, the commencement of marketing with respect to such Subject equity offering , it shall give each Purchaser written notice of its intention (including, in the case of a registered public offering and to the
extent possible, a copy of the draft prospectus included in the registration statement filed in respect of such offering) describing, to the extent then known, the anticipated amount of securities, range of prices, timing and other material terms of
such offering. Each Purchaser shall have three (3) Business Days from the date of receipt of any such notice to notify the Company in writing that it intends to exercise such preemptive purchase rights and as to the amount of New Equity
Securities such Purchaser desires to purchase, up to the maximum amount calculated pursuant to Section 5.1(a) (the “Designated Securities”). Such notice shall constitute a binding indication of interest of such Purchaser
to purchase the Designated Securities so specified at the range of prices and other terms set forth in the Company’s notice to it at the same time as and in conjunction with (and subject to) the closing of the Subject Equity Offering; provided,
however, that if the price of the Subject Equity Offering shall be in excess of the upper range set forth in such notice, such Purchase is indication of interest and shall be non-binding. The failure of a Purchaser to respond during such three
(3) Business Day period shall, solely with respect to the Purchaser who fails to respond, constitute a waiver of the preemptive rights only in respect of such offering. 

  
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 (ii) If the Company proposes to make a Subject Equity Offering that is not an
underwritten public offering (a “Private Placement”), the Company shall give each Purchaser written notice of its intention, describing, to the extent then known, the anticipated amount of securities, price and other material terms
upon which the Company proposes to offer the same. Each Purchaser shall have three (3) Business Days from the date of receipt of the notice required by the immediately preceding sentence to notify the Company in writing that it intends to
exercise such preemptive purchase rights and as to the amount of Designated Securities such Purchaser desires to purchase, up to the maximum amount calculated pursuant to Section 5.1(a). Such notice shall constitute the binding agreement
of such Purchaser to purchase the amount of Designated Securities so specified (or a proportionately lesser amount if the amount of New Equity Securities to be offered in such Private Placement is subsequently reduced) upon the price and other terms
set forth in the Company’s notice to it. The failure of a Purchaser to respond during the three (3) Business Day period referred to in the second preceding sentence shall, solely with respect to the Purchaser who fails to respond,
constitute a waiver of the preemptive rights in respect of such offering only. As a condition to the Company’s obligation to provide the notice required in this paragraph, except to the extent required by applicable law, each Purchaser shall
maintain the confidentiality of the proposed Private Placement until such time as such Private Placement is publicly announced or otherwise abandoned by the Company, regardless of whether such Purchaser intends to exercise its preemptive rights with
respect to the Private Placement, provided, however, that in no event shall this obligation apply to Purchaser for more than ninety (90) days following the date of delivery to Purchaser of such notice by the Company. 

(c) (i) If a Purchaser exercises its preemptive purchase rights provided in Section 5.1(b)(ii), the closing of the purchase of the
New Equity Securities with respect to which such right has been exercised shall be conditioned on the consummation of the Subject Equity Offering giving rise to such preemptive purchase rights and shall take place simultaneously with such closing;
provided that the actual amount of Designated Securities to be sold to such Purchaser pursuant to its exercise of preemptive rights hereunder shall be reduced proportionately if the aggregate amount of New Equity Securities sold in the
Subject Equity Offering is reduced and, at the option of such Purchaser (to be exercised by delivery of written notice to the Company within three (3) Business Days of receipt of notice of such increase), shall be increased proportionately if
such aggregate amount of New Equity Securities sold in the Subject Equity Offering is increased. In connection with its purchase of Designated Securities, each Purchaser shall execute all applicable documents and agreements with respect to such
transaction in form and substance reasonably satisfactory to the Company containing representations, warranties and agreements of the Purchaser consistent with the other purchasers. 

(ii) If a Purchaser exercises its preemptive purchase rights provided in Section 5.1(b)(i), the Company shall
offer such Purchaser, if such underwritten public offering is consummated, the Designated Stock (as adjusted to reflect the actual size of such offering when priced) at the same price as the New Equity Securities is offered to the public and shall
provide written notice of such price to the Purchaser as soon as practicable prior to such consummation. Contemporaneously with the execution of any underwriting agreement entered into between the Company and the underwriters of such underwritten
public offering, such Purchaser shall enter into an instrument in form and substance reasonably satisfactory to the Company acknowledging such Purchaser’s binding obligation to purchase the Designated Securities to be acquired by it and
containing representations, warranties and agreements of such Purchaser that are customary in such transactions, and the failure to enter into such an instrument at or prior to such time shall constitute a waiver of the preemptive rights only in
respect of such offering. Any offers and sales pursuant to this Section 5.1 in the context of a registered public offering shall also be conditioned on reasonably acceptable representations and warranties of such Purchaser regarding its
status as the type of offeree to whom a private sale can be made concurrently with a registered public offering in compliance with applicable securities laws. 

  
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 (d) In the event a Purchaser fails to exercise its preemptive purchase rights provided in this
Section 5.1 within the applicable three (3) Business Day period or, if so exercised, a Purchaser does not consummate such purchase within the applicable period, the Company shall thereafter be entitled during the period of 90 days
following the conclusion of the applicable period to sell or enter into an agreement (pursuant to which the sale of New Equity Securities covered thereby shall be consummated, if at all, within 60 days from the date of such agreement) to sell the
New Equity Securities not purchased pursuant to this Section 5.1 at the price and on the terms set forth in the applicable notice. In the event the Company has not sold the New Equity Securities or entered into an agreement to sell the
New Equity Securities within said 90-day period, the Company shall not thereafter offer, issue or sell such New Equity Securities without first offering such securities to the Purchasers in the manner provided in this Section 5.1. 

(e) The Purchasers shall not have any rights to participate in the negotiation of the proposed terms of any Subject Equity Offering;
provided, however, that the foregoing shall not prevent any Purchaser Designee from exercising his powers and duties in his capacity as a member of the Board. 

(f) The Company and each Purchaser shall cooperate in good faith to facilitate the exercise of the Purchaser’s preemptive rights
hereunder, including securing any required approvals or consents, in a manner that does not jeopardize the timing, marketing, pricing or execution of any offering of the Company’s securities. 

5.2. Reasonable Best Efforts; Further Assurances. 

Each of the parties hereto agrees to use its reasonable best efforts to take, or cause to be taken, all action, and to do, or cause to be done,
all things necessary or desirable under applicable legal requirements, to consummate and make effective the transactions contemplated by this Agreement and the Transaction Documents. If at any time after the Execution Date, any further action is
necessary or desirable to carry out the purposes of this Agreement and the Transaction Documents, the parties hereto shall use their reasonable best efforts to take or cause to be taken all such necessary or desirable action and execute, and deliver
and file, or cause to be executed, delivered and filed, all necessary or desirable documentation. Notwithstanding the foregoing, in no event shall any of the parties hereto be required to amend the terms of this Agreement or any of the Transaction
Documents in order to comply with the terms of this Section 5.2. 

  
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 5.3. Indemnity. 

(a) The Company agrees to indemnify and hold each Purchaser and each member of the Purchaser Group and each of their respective officers,
directors, partners, managers, members, Affiliates, employees and agents, and each Person who controls any of the foregoing (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act) and the officers,
directors, partners, managers, members, Affiliates, employees and agents of each such controlling Person (each an “Indemnified Party” and collectively the “Indemnified Parties”) harmless against any and all losses,
claims, liabilities, damages (excluding incidental, special, indirect and consequential damages) and expenses of any kind or nature whatsoever (“Losses”), including, without limitation, the reasonable fees and disbursements of
counsel and all other reasonable expenses incurred (and as incurred) in connection with prosecuting, investigating, defending or preparing to defend any action, suit, proceeding (including any investigation, litigation or inquiry), demand or cause
of action that may be incurred by them or asserted against or involve any of them as a result of, arising out of, or in any way related to: 

(i) any inaccuracy in or breach of any of the Company’s representations and warranties in Section 3 of this
Agreement or in any certificate delivered by the Company pursuant to this Agreement; 
 (ii) the Company’s breach of
agreements or covenants made by the Company in this Agreement or in any certificate delivered by the Company pursuant to this Agreement; and 

(iii) claims by third parties relating to or arising out of actions or omissions by the Company or its directors, officers,
directors, employee or consultants with respect to the transactions contemplated by this Agreement or the Transaction Documents, or any transaction or any claim, litigation, investigation or proceeding relating to any of the foregoing, whether or
not any Indemnified Party is or is threatened to be made a party thereto. 
 (b) An Indemnified Party will give written notice to the
Company of any claim with respect to which it seeks indemnification under this Section 5.3 promptly after discovery by such Indemnified Party of any matters giving rise to a claim for indemnification; provided that the failure of
any Indemnified Party to so notify the Company of any such action shall not relieve the Company from any liability which it may have to such Indemnified Party unless the Company shall have been materially and adversely prejudiced by the failure of
such Indemnified Party to so notify the Company. In case any such action shall be brought against any Indemnified Party and the Indemnified Party has notified the Company of the commencement thereof, the Company shall be entitled to assume the
defense thereof, with counsel reasonably satisfactory to such Indemnified Party, and after notice from the Company to such Indemnified Party of its election so to assume the defense thereof, the Company will not be liable to such Indemnified Party
under this Section 5.3 for any legal or other expense subsequently incurred by such Indemnified Party in connection with the defense thereof; provided, however, that (1) if the Company shall elect not to assume the
defense of such claim or action or (2) if the Indemnified Party reasonably determines that there is a conflict between the positions of the Company and of the Indemnified Party in defending such claim or action, then separate counsel for the
Indemnified Party shall be entitled to participate in the defense, and the Company shall be liable for any reasonable and documented legal or other expenses incurred by the Indemnified Party in connection with the defense. Notwithstanding the
foregoing, in connection with a claim for indemnification by an Indemnified Party pursuant to Section 5.3(a)(iii), the Indemnified Party shall be entitled to retain one separate counsel (and local counsel if necessary) and the Company
shall be liable to such Indemnified Party under this Section 5.3 for any legal or other expense subsequently incurred by such Indemnified Party in connection with the defense thereof. The Company agrees that it shall not, without the
Indemnified Party’s prior written consent (which shall not be unreasonably withheld or delayed), settle or compromise any claim or consent to entry of any judgment in respect thereof in any threatened or pending action, suit, claim or
proceeding in respect of which indemnification has been sought hereunder unless such settlement or compromise includes an unconditional release of such Indemnified Party from all liability arising out of such action, suit, claim or proceeding. 

  
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 (c) All reasonable expenses incurred by an Indemnified Party and payable by the Company
hereunder in connection with any threatened or pending action, suit, proceeding (including any investigation, litigation or inquiry), demand or cause of action shall be paid by the Company in advance of the final disposition of such action, suit,
proceeding (including any investigation, litigation or inquiry), demand or cause of action if so requested by the Indemnified Party, within thirty (30) days after the receipt by the Company of a statement or statements from the Indemnified
Party requesting such advance or advances. The Indemnified Party may submit such statements from time to time. The Indemnified Party’s entitlement to such expenses shall include those incurred in connection with any proceeding by the
Indemnified Party seeking an adjudication or award in arbitration pursuant to this Section 5.3. Such statement or statements shall reasonably evidence the expenses incurred by the Indemnified Party in connection therewith and shall
include or be accompanied by a written undertaking by or on behalf of the Indemnified Party to repay such amount if it is ultimately determined that the Indemnified Party is not entitled to be indemnified against such expenses by the Company
pursuant to this Section 5.3. Each written undertaking to pay amounts advanced must be an unlimited general obligation but need not be secured, and shall be accepted without reference to financial ability to make repayment. 

(d) The obligations of the Indemnifying Party under this Section 5.3 shall survive the consummation of the transactions
contemplated by this Agreement or termination of this Agreement indefinitely; provided that any such obligations pursuant to Section 5.3(a)(i) shall be subject to the periods set forth in Section 8.4. 

(e) No party to this Agreement (or any of its Affiliates) shall, in any event, be liable or otherwise responsible to any other party (or any
of its Affiliates) for any consequential or punitive damages of such other party (or its Affiliates) arising out of or relating to this Agreement or the performance or breach hereof. 

  
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 5.4. Consents and Approvals.  

(a) Subject to Sections 5.4(b), from and after the date hereof, the Company and each Purchaser shall use its reasonable best efforts to
prepare and file all necessary documentation, to effect all necessary applications, notices, petitions, filings and other documents, and to obtain all necessary permits, consents, orders, approvals and authorizations of, or any exemption by, all
third parties and Governmental Authorities, and expiration or termination of any applicable waiting periods, necessary or advisable for it to consummate the transactions contemplated by this Agreement and the other Transaction Documents, and to
perform the covenants contemplated by this Agreement and the other Transaction Documents, in each case to be performed by it. The parties shall reasonably cooperate with each other in all actions contemplated by the previous sentence. 

(b) The Company and each Purchaser shall use reasonable best efforts to obtain or submit, as the case may be, as promptly as practicable, the
approvals and authorizations of, filings and registrations with, and notifications to applicable Governmental Authorities, or expiration or termination of any applicable waiting period, under any applicable competition or merger control laws of any
jurisdictions (collectively, the “Antitrust Regulations”), for the transactions contemplated by this Agreement and the other Transaction Documents, to the extent such Antitrust Regulations are applicable to such Purchaser. 

5.5. Use of Proceeds. 
 The proceeds
received by the Company from the issuance and sale of the Securities shall be used by the Company for general corporate purposes. 
 5.6.
Takeover Provisions. 
 Following the date hereof, the Company shall take all reasonable actions to ensure that (i) to the extent
permissible under law, no “fair price”, “moratorium”, “control share acquisition” or other form of antitakeover statute or regulation under Delaware law, including Section 203 of the DGCL, or other state law in
which the Company may become incorporated, (ii) no anti-takeover provision in the Organizational Documents of the Company or other similar organizational documents of its Subsidiaries, and (iii) no shareholder rights plan, “poison
pill” or similar measure, is applicable to a Purchaser’s ownership of the Securities or the purchase of Securities pursuant to the terms of this Agreement (each a “Takeover Provision”). If any Takeover Provision shall
become applicable to a Purchaser or the transactions contemplated hereby, including, without limitation, as a result of the conversion of the Series A Preferred Stock into Common Stock or pursuant to the exercise of the rights provided for in
Section 5.1, the Company and the Board shall grant such approvals and take such actions as are necessary so that the transactions contemplated hereby may be consummated as promptly as practicable on the terms contemplated hereby and
otherwise act to eliminate the effects of such Takeover Provisions on each Purchaser and the transactions contemplated hereby. 

  
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 5.7. Section 16 Matters. 

Notwithstanding anything to the contrary contained in the Transaction Documents, if there exists a period (the “Section 16(b)
Period”) during which a Purchaser’s purchase of any security pursuant to any Transaction Document would result in liability under Section 16(b) of the Exchange Act, the period during which such security may be purchased if
prescribed by such Transaction Document, shall, if practicable, be extended until the date that is the equivalent number of days of such Section 16(b) Period after the later of (i) the expiration date to purchase such security, if any, or
(ii) the date of the end of such Section 16(b) Period. 
 5.8. Registration and Quotation. 

(a) So long as a Purchaser Beneficially Owns any Securities, the Company will cause the Common Stock to continue at all times to be registered
under Section 12(b) or 12(g) of the Exchange Act, will comply in all respects with its reporting and filing obligations under the Exchange Act, and will not take any action or file any document (whether or not permitted by the Exchange Act or
the rules thereunder) to terminate or suspend such reporting and filing obligations. 
 (b) The Company shall use its reasonable best
efforts (i) so long as the Purchasers Beneficially Own any Securities, to continue the trading of the Common Stock on the OTCBB or, at the Company’s option, to cause the Common Stock to be listed on the NASDAQ Global Select Market, the
NASDAQ Global Market, the NASDAQ Capital Market, NYSE Amex, or the NYSE, and to comply in all respects with the Company’s reporting, filing and other obligations under the bylaws or rules of the securities exchange or other market on which the
Common Stock is then quoted or listed for trading. Notwithstanding the foregoing, in no event shall the Company take any action in furtherance of this Section 5.8(c) that is inconsistent with or in conflict with its other obligations
pursuant to this Agreement and the Transaction Documents without the prior written consent of the Purchasers. The Company shall pay all fees and expenses in connection with satisfying its obligations under this Section 5.8. 

5.9. Private Offering. 

Neither the Company, any of its Subsidiaries nor any of their respective Affiliates will sell, offer for sale or solicit offers to buy or
otherwise negotiate in respect of any “security” (as defined in the Securities Act) that could reasonably be expected be integrated with the sale of the Securities in a manner that could require the registration of the Securities under the
Securities Act. 
 5.10. Blue Sky. 

The Company shall take such action as the Company shall reasonably determine is necessary in order to obtain an exemption for, or to qualify
the Securities for, sale to the Purchasers pursuant to this Agreement under the Securities Act and applicable state securities and “blue sky” laws within the United States (or to obtain an exemption from such qualification), and shall,
upon request, provide evidence of any such action so taken to the Purchasers on or prior to each respective Closing for the issuance of such Securities. The Company agrees to provide to the Purchasers a copy of any filing it proposes to make with
the SEC with respect to the initial sale of the Securities to the Purchasers to the extent required under the Securities Act. The Company shall pay all fees and expenses in connection with satisfying its obligations under this
Section 5.10. 

  
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 5.11. Board Representation and Strategic Investment Committee. 

(a) The Company shall take all requisite action such that on the Closing Date hereof, the size of the Board shall be set at five
(5) members and one (1) individual designated by the Purchasers (the “Purchaser Designee”) as a Board nominee shall be appointed to the Board. The rights of the Purchasers under this Section 5.13 shall be exercised by
a majority in interest of the Purchasers. The Purchaser Designee will be subject to approval by the Board, it being understood that Mr. GianDomenico Trombetta has been so approved. In case of rejection of a future nominee other than
Mr. Trombetta, the Purchasers will indicate alternative candidates for Purchaser Designee. Mr. Trombetta shall be appointed as the President/CEO of the Company’s Dental Division. 

(b) (i) From and after the date hereof, so long as the Investor Group continues to hold at least a majority of the sum of (x) number of
shares of Common Stock purchased by the Purchasers at the Closing and (y) a number of shares of Common Stock equal to the product of the number of shares of Series A Preferred purchased by the Purchasers at the Closing multiplied by the
quotient of (A) the Stated Value (as defined in the Certificate of Designation) divided by (B) the Optional Conversion Price (as defined in the Certificate of Designation) (the “Minimum Equity”) , then the Company shall cause one
(1) Purchaser Designee to be nominated by the Company to serve on the Board and the total number of members of the Board shall be five (5) or fewer; provided that the number of directors of the Company may be increased (x) after the
Purchasers no longer have the right to nominate a Purchaser Designee for election to the Board of Directors, (y) in connection with a Qualified Equity Offering (as defined in the Certificate of Designation) or (z) upon the consent of the
Required Holders (as defined in the Certificate of Designation). The Purchaser Designee shall be appointed to the Board on the Closing Date or to the extent designated following the Closing Date, shall be appointed to the Board promptly following
notice from the Purchasers. The Purchaser Designee shall be appointed to serve on committees of the Board as the Board of Directors shall determine. 

(c) With respect to the Purchaser Designee, subject to approval of the Purchaser Designee in accordance with Section 5.11(a): 

(i) The Company shall use its reasonable best efforts to have such Purchaser Designee elected as director of the Company,
including, without limitation, including such Purchaser Designee in the Company’s proxy statement for the election of directors as part of “management’s slate”, soliciting proxies for such Purchaser Designee to the same extent as
it does for any of its nominees to the Board, and including the recommendation of the Board in favor of election of the Purchaser Designee. In the event a Purchaser Designee is not elected at a stockholders meeting at which such designee is up for
election, the Purchasers shall nominate another person and the Company shall cause such substitute Purchaser Designee to be appointed to the Board. 

  
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 (ii) Any vacancy in the position of a Purchaser Designee shall only be filled
with another Purchaser Designee. Any vacancy created by any removal of a Purchaser Designee or an election of the Purchasers to defer appointing a Purchaser Designee shall also only be filled with another Purchaser Designee. The Company shall not
take any action to remove any Purchaser Designee or fill a vacancy reserved for a Purchaser Designee without the consent of the Purchasers. Any replacement Purchaser Designee shall be appointed to the Board promptly following notice from the
Purchasers and in any event, within twenty (20) Business Days. During such twenty-day period, the Board shall not take any action intended to adversely affect the Purchasers. 

(iii) Each Purchaser Designee shall be given notice of (in the same manner that notice is given to other members of the Board)
all meetings (whether in person, telephonic or otherwise) of the Board, including all committee meetings with respect to committees on which such Purchaser Designee serves. The Company will, unless prohibited by Delaware law, conduct the meetings of
the Board so that the Purchaser Designee can participate by telephone or other remote access method. Each Purchaser Designee shall receive a copy of all notices, agendas and other materials distributed to the Board, whether provided to directors in
advance or during or after any meeting, regardless of whether such Purchaser Designee will be in attendance at the meeting. 
 (d) In
addition to any other indemnification rights the Purchaser Designees have pursuant to this Agreement, the Certificate of Incorporation and the Bylaws, each such Purchaser Designee that serves on the Board shall be given the opportunity to enter
into, and the Company agrees to enter into, any indemnification agreement or side letter relating to director indemnification or limitation of liability that the Company enters into with any other member of the Board. For the avoidance of doubt, the
foregoing sentence is intended to afford the Purchaser Designee “most favored director” status with respect to indemnification arrangements as in effect from time to time relative to any other member of the Board. The Company shall
maintain director and officer insurance covering the Purchaser Designees on the same terms and with the same amount of coverage as is provided to other members of the Board. So long as the Purchaser Designee shall not also be an officer or employee
of the Company, any Subsidiary or any division or business unit thereof, (i) the Company shall reimburse the reasonable expenses incurred by the Purchaser Designees in connection with attending (whether in person or telephonically) all meetings
of the Board or committees thereof or other Company related meetings to the same extent as all other members of the Board are reimbursed for such expenses (or, in case any such expense reimbursement policy shall apply only to non-employee directors,
to the same extent as all other non-employee directors), and (ii) the Purchaser Designees shall be entitled to the same compensation for service on the Board, including, without limitation, cash fees, stock options, restricted stock and other
equity awards, as is provided to other non-employee directors. 
 (e) The Company and the Purchasers shall take or cause to be taken all
lawful action necessary to ensure at all times as of and following the Closing Date that the Organizational Documents of the Company are not inconsistent with the provisions of this Agreement and the Transaction Documents or the transactions
contemplated hereby or thereby. 

  
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 (f) The Company shall form a Strategic Investment Committee (the “SIC”) consisting of
three (3) members as follows: (i) the Chief Executive Officer of the Company, (ii) the Purchaser Designee if a Purchaser Designee is then serving on the Board of Directors, and (iii) a third member who shall be mutually agreed to
in good faith by the Company’s Chief Executive Officer and the Purchaser Designee. The SIC shall (i) be exclusive gateway for the Specified Matters (as defined in the Certificate of Designation) to be evaluated and recommended to the Board
and (ii) have special authority to make recommendations with respect to the investment of cash balances of the Company in U.S. Treasury bills and other high-grade publicly traded securities in conformity with cash investment policies to be
approved by the Company, in each case, so long as the Investor Group holds at least the Minimum Equity. The SIC shall have at least ten (10) business days to consider and make a recommendation with respect to a Specified Matter presented to it
by the Chief Executive Officer of the Company; provided, that if the Chief Executive Officer of the Company advises the other members of the SIC that (i) the opportunity represented by the Specified Matter shall require action of the Company
within three (3) business days, (ii) if the SIC shall not act within such period of time the advantages to the Company of such Specified Matter shall be jeopardized, or (iii) the failure to approve such Specified Matter shall have an
adverse effect on the Company, the SIC shall have a reasonable period of time but not less than two (2) business days to consider such Specified Matter. As a general rule, in case of rejection by the SIC, Specified Matters are not submitted to
the Board of Directors. However, members of the SIC who are also members of the Board of Directors have the right to submit rejected Specified Matters to the Board of Directors. 

5.12. Corporate Opportunity. 

In recognition that each Purchaser and its Representatives currently have, and may in the future have or may consider acquiring, investments in
Persons with respect to which each Purchaser or its Representatives may serve as an advisor, a director or in some other capacity, and in recognition that each Purchaser and its Representatives may have myriad duties to various investors and
partners, and in anticipation that the Company and the Medical JV, on the one hand, and each of the Purchasers, on the other hand, may engage in the same or similar activities or lines of business and have an interest in the same areas of corporate
opportunities, and in recognition of the benefits to be derived by the Company hereunder and in recognition of the difficulties which may confront any advisor who desires and endeavors fully to satisfy such advisor’s duties in determining the
full scope of such duties in any particular situation, the provisions of this Section 5.14 are set forth to regulate, define and guide the conduct of certain affairs of the Company as they may involve such Purchaser. The Company agrees on its
behalf and on behalf of the Medical JV as follows: 
 (a) Such Purchaser and its respective Representatives shall have the right:
(i) to directly or indirectly engage in any medical technology acquisition, development and commercialization or other lines of business that are the same as or similar to those pursued by, or competitive with, the Company and the Medical JV,
(ii) to directly or indirectly do business with any client or customer of the Company and the Medical JV, (iii) to take any other action that such Purchaser believes is necessary to or appropriate to fulfill its obligations as described in
the first sentence of this Section 5.14, and (iv) not to present potential transactions, matters or business opportunities to the Company or the Medical JV, and to pursue, directly or indirectly, any such opportunity for itself, and
to direct any such opportunity to another person. 

  
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 (b) Such Purchaser and its Representatives shall have no duty (contractual or otherwise) to
communicate or present any corporate opportunities to the Company, the Medical JV or any of their respective stockholders, Subsidiaries or Affiliates or to refrain from any actions specified in this Section 5.14, and the Company, on its
own behalf and on behalf of its stockholders, the Medical JV, their respective Subsidiaries and Affiliates, hereby renounces and waives any right to require such Purchaser or any of its Representatives to act in a manner inconsistent with the
provisions of this Section 5.14. 
 (c) None of the Purchasers, nor any of their respective Representatives, shall (i) be
liable to the Company, the Medical JV or any of their respective stockholders, Subsidiaries or Affiliates for breach of any duty (contractual or otherwise) solely by reason of any activities or omissions of the types referred to in this
Section 5.14 or of any such person’s participation therein, or (ii) have any duty to communicate or present any activities or omissions of the types referred to in this Section 5.14 to the Company, the Medical JV or
any of their respective stockholders, Subsidiaries or Affiliates. The Purchasers and their respective Representatives shall have the right to hold any of the activities or omissions of the types referred to in this Section 5.14 for their
own accounts, or the account of another Person, or to recommend, sell, assign or otherwise transfer such activity or omission to Persons other than the Company, the Medical JV or any of their respective stockholders, Subsidiaries or Affiliates. The
Company acknowledges that this Section 5.14 renounces specified business opportunities as contemplated by Section 122(17) of the DGCL. To the fullest extent permitted by the DGCL, the Company hereby waives any claim against each
Purchaser and its Representatives that is based on fiduciary duties, the corporate opportunity doctrine or any other legal theory which could limit any Purchaser or its Representatives from pursuing or engaging in transactions contemplated by this
Section 5.14; provided that no such waiver is intended to waive any fiduciary duties that the Purchaser Designee may have to the Company as a member of the Board of Directors or as an officer or employee of the Company or any Subsidiary
or business unit thereof, including without limitation, the duty of confidentiality. 
 5.13. Legends. 

(a) All certificates representing the Series A Preferred Stock or Series A Conversion Shares shall bear a legend, as applicable, substantially
in the following form: 
 “THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE TRANSFERRED, SOLD OR OTHERWISE DISPOSED OF EXCEPT WHILE A REGISTRATION STATEMENT RELATING THERETO IS IN EFFECT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN
EXEMPTION FROM REGISTRATION UNDER SUCH ACT OR SUCH LAWS. 
 THE COMPANY WILL FURNISH WITHOUT CHARGE TO EACH STOCKHOLDER WHO SO REQUESTS AT
THE COMPANY’S PRINCIPAL OFFICE THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE PARTICIPATING, OPTIONAL AND OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS ON SUCH PREFERENCES
AND/OR RIGHTS.” 

  
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 (b) Upon request of a Purchaser, upon receipt by the Company of an opinion of counsel reasonably
satisfactory to the Company to the effect that such legend is no longer required under the Securities Act or applicable state laws, as the case may be, the Company shall promptly cause the first paragraph of the legend to be removed from any
certificate for any Securities to be so transferred. The second paragraph shall be removed if such paragraph is no longer required pursuant to the DGCL. 

5.14. Rights Relating to Dental Business. 

(a) The Purchasers shall have the option to purchase shares of the Dental Company under the following terms and conditions: (i) such
option shall expire on December 31, 2017; (ii) in the case of the initial public offering of the Dental Company, taking into account the Purchasers’ ownership percentage of the Dental Company after giving effect to their rights as a
current shareholder of the Company on account of their ownership of Common Stock and Series A Preferred Stock as provided herein and in the Certificate of Designation, the Purchasers shall have the one-time right to acquire enough additional shares
of common stock of the Dental Company to increase their ownership percentage of the Dental Company by up to an additional fifteen percent (15%) in the aggregate for all Purchasers taken as a whole on a post-transaction basis (the
“Additional Dental Equity”); provided, however, that if the Purchasers’ acquisition of the Additional Dental Equity shall adversely affect the Company’s ability to consolidate the Dental Company under GAAP, the Additional Dental
Equity percentage shall be decreased as necessary to permit consolidation, but not below nine percent (9%); (iii) the price per share payable by the Purchasers for Additional Dental Equity shall be equal to the gross per share IPO price to the
public minus half (50%) of the underwriting fees and commissions; and (iv) the purchase option shall be described in the IPO prospectus and exercised prior to the circulation of the preliminary prospectus for the IPO (subject to settlement
being conditioned to closing of the IPO). 
 (b) The procedure for the Purchasers’ exercise of the option provided in
Section 5.14(a) above shall, mutatis mutandis, be the same as that provided in Section 5.1 hereof for the exercise of the Purchasers’ preemptive rights in the event of an underwritten public offering of New Equity Securities.

 SECTION 6. CONDITIONS TO THE CLOSING 

6.1. Conditions to the Obligations of Purchasers To Close. Each of the following actions shall be taken, or documents delivered, as the
case may be, by the Company on or prior to the Closing Date, any of which may be waived only in the sole discretion of the Purchasers: 

(a) Accuracy of Representations and Warranties. The representations and warranties of the Company set forth in Section 3 of
this Agreement shall be true and correct as of the Closing Date and such Purchaser shall have received a certificate signed on behalf of the Company by the Chief Executive Officer or the Chief Financial Officer of the Company to the foregoing
effect. 

  
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 (b) Performance. The Company shall have performed or complied in all material respects
with all agreements, obligations, covenants and conditions contained in this Agreement to be performed or complied with by the Company on or prior to the Closing Date and such Purchaser shall have received a certificate signed on behalf of the
Company by the Chief Executive Officer or the Chief Financial Officer of the Company to the foregoing effect. 
 (c) Financing.
Innovest S.p.A., an Italian corporation and the controlling shareholder of each Purchaser (“Innovest”), shall have secured third-party capital commitments to fund the purchase of the Securities and each Purchaser shall be ready to fund its
share of the consideration provided for by this Agreement, it being understood that if sufficient third-party capital commitments are not received by Innovest prior to, or funding of such third-party commitments does not take place on, the Closing
Date, this Agreement will become null and void without any liability for any Purchaser. 
 (d) Board of Directors. The Company shall
have taken all actions necessary and appropriate to cause Mr. GianDomenico Trombetta to be appointed to the Board and as President/CEO of the Company’s dental division effective immediately upon the Closing. 

(e) Certificates of Designation. The Certificate of Designation shall have been duly filed with the Secretary of State of the State of
Delaware and satisfactory evidence of such filing shall have been delivered to such Purchaser. 
 (f) Counsel’s Opinion. Such
Purchaser shall have received an opinion from the Company’s counsel, Golenbock Eiseman Assor Bell & Peskoe LLP, dated the Closing Date, and substantially in the form of Exhibit B hereto. 

(g) Registration Rights Agreement. The Company shall have executed and delivered to such Purchaser the Registration Rights Agreement in
the form of Exhibit C hereto (the “Registration Rights Agreement”). 
 (h) Stock Certificates. The Company
shall have delivered to such Purchaser one or more validly issued stock certificates to such Purchaser representing the Securities purchased by such Purchaser, duly executed by the appropriate officers of the Company. 

(i) Secretary’s Certificate. Such Purchaser shall have received a certificate, dated the Closing Date, of the Secretary of the
Company attaching (i) a true and complete copy of the Certificate of Incorporation of the Company as filed with the Secretary of State of the State of Delaware, with all amendments thereto, (ii) true and complete copies of the
Company’s Bylaws in effect as of such date, and (iii) resolutions of the Board authorizing the execution and delivery of this Agreement and the Transaction Documents and the transactions contemplated hereby and thereby. 

If any of the conditions hereinabove provided for in this Section 6.1 above shall not have been fulfilled when and as required by
this Agreement to be fulfilled, the obligations of the Purchasers hereunder may be terminated by the Purchasers by notifying the Company of such termination in writing or by electronic communication at or prior to the Closing Date, and this
Agreement shall become null and void and without any liability to any of the Purchasers. 

  
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 6.2 Conditions to the Obligation of the Company to Close. 

Each of the following actions shall be taken, or documents delivered, as the case may be, by each of the Purchasers on or prior to the Closing
Date, any of which may be waived only in the sole discretion of the Company: 
 (a) Accuracy of Representations and
Warranties. The representations and warranties of such Purchaser set forth in Section 4 of this Agreement shall be true and correct as of the Closing Date. 

(b) Subscription Amount. Such Purchaser shall have delivered the applicable purchase price as provided in
Section 2.1 hereof on or prior to April 30, 2014 or such other date as agreed upon by the parties hereto. 
 (c)
Registration Rights Agreement. Such Purchaser shall have executed and delivered to the Company the Registration Rights Agreement. 

If any of the conditions hereinabove provided for in this Section 6.2 above shall not have been fulfilled when and as required by
this Agreement to be fulfilled, the obligations of the Company hereunder may be terminated by the Company by notifying the Purchasers of such termination in writing or by electronic communication at or prior to the Closing Date, and this Agreement
shall become null and void and without any liability to the Company. 
 SECTION 7. INTERPRETATION OF THIS AGREEMENT 

7.1. Terms Defined 
 As
used in this Agreement, the following terms have the respective meanings set forth below or set forth in the Section hereof following such term: 

Affiliate: shall mean any Person or entity, directly or indirectly, controlling, controlled by or under common control with such Person
or entity. 
 Agreement: shall mean this Investment Agreement, dated as of April 15, 2014, among the Company and the Purchasers,
as the same may be amended from time to time. 
 Antitrust Regulations: shall have the meaning set forth by
Section 5.4(b). 
 Approved Market: shall mean the NASDAQ Global Select Market, the NASDAQ Global Market, the NASDAQ
Capital Market, the NYSE Amex, or the New York Stock Exchange. 
 Authorized Preferred Stock: shall have the meaning set forth in
Section 3.3(a). 
 Beneficially Own or Beneficial Ownership: shall mean, with respect to any securities, having
“beneficial ownership” of such securities (as determined pursuant to Rule 13d-3 under the Exchange Act). 

  
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 Board: shall mean the Board of Directors of the Company. 

Business Day: shall mean any day except Saturday, Sunday and any day which shall be a legal holiday or a day on which banking
institutions in the State of New York generally are authorized or required by law or other governmental actions to close. 
 Bylaws:
shall mean the Amended and Restated Bylaws of the Company, as amended from time. 
 Certificate of Designation: shall mean the Series
A Preferred Certificate of Designation of the Company. 
 Certificate of Incorporation: shall mean the Certificate of Incorporation
of the Company, as amended from time. 
 Closing: shall have the meaning set forth in Section 2.2. 

Closing Date: shall mean May 15, 2014. 

Code: shall mean the Internal Revenue Code of 1986, as amended, and the Treasury Regulations promulgated thereunder. 

Commitment and Commitments: shall have the meaning set forth in Section 3.12. 

Common Stock: shall have the meaning set forth in Section 1. 

Company: shall have the meaning set forth in the Preamble. 

Company Bank Account: shall have the meaning set forth in Section 2.1. 

Company Benefit Plans: shall have the meaning set forth in Section 3.13(b). 

Company Disclosure Letter: shall have the meaning set forth in the first paragraph of Section 3. 

Company Intellectual Property: shall have the meaning set forth in Section 3.16(b). 

Company Product: shall have the meaning set forth in Section 3.34. 

Company SEC Reports: shall have the meaning set forth in Section 3.7(a). 

Contingent Obligation: shall mean, as to any Person, any direct or indirect liability, contingent or otherwise, of that person with
respect to any indebtedness, lease, dividend or other obligation of another person if the primary purpose or intent of the person incurring such liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that
such liability will be paid or discharged, or that any agreements relating thereto will be complied with, or that the holders of such liability will be protected (in whole or in part) against loss with respect thereto. 

  
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 Contract: shall mean any agreement, contract, commitment, understanding, arrangement,
restriction or other instrument, whether oral or written, to which the Company or any of its Subsidiaries is a party, which includes any rights or obligations thereof, or which otherwise relates to or affects any of their respective assets,
including, without limitation, any indenture, lease, mortgage, deed of trust, loan, credit or security agreement, note or other evidence of indebtedness, guaranty, stockholders agreement, license, joint venture agreement, distribution
agreement, or employment, severance or consulting agreement. 
 Dental Company: means a future entity separate from, and not a
wholly-owned Subsidiary of, the Company to which all or substantially all assets comprising the Company’s current dental business are transferred. 

Designated Stock: shall have the meaning set forth in Section 5.1(b)(i). 

Disqualification Event: shall have the meaning set forth in Section 3.24(b). 

DGCL: shall mean the Delaware General Corporation Law. 

Environmental Claims: shall mean, in respect of any Person, (i) any and all administrative, regulatory or judicial actions, suits,
orders, decrees, demands, directives, claims, liens, proceedings or written notices of noncompliance, liability or violation by any Governmental Authority, alleging potential presence or Release of, or exposure to, any Hazardous Materials at any
location, whether or not owned, operated, leased or managed by such Person, or any violation of Environmental Law or agreement pertaining to Hazardous Materials or Environmental Laws or (ii) any and all indemnification, cost recovery,
compensation or injunctive relief resulting from the actual or alleged presence or Release of, or exposure to, any Hazardous Materials or violation of Environmental Laws. 

Environmental Laws: shall mean all federal, state, local and foreign laws (including international conventions, protocols and
treaties), common law, rules, regulations, orders, decrees, judgments, binding agreements or Environmental Permits issued, promulgated or entered into, by or with any Governmental Authority, relating to pollution, Hazardous Materials, natural
resources or the protection, investigation or restoration of the environment as in effect on the date of this Agreement. 
 Environmental
Permits: shall mean all permits, licenses, registrations and other governmental authorizations required under applicable Environmental Laws. 

ERISA: shall have the meaning set forth in Section 3.13(b). 

ERISA Affiliate: shall have the meaning set forth in Section 3.13(c)(2). 

Exchange Act: shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder. 

FDCA: shall have the meaning set forth in Section 3.34. 

FDA: shall mean the U.S. Food and Drug Administration. 

  
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 Fully Diluted Basis: means all outstanding shares of the Common Stock assuming the
exercise of all outstanding stock, warrants, rights, calls, options or other securities exchangeable or exercisable for, or convertible into, shares of Common Stock without regard to any restrictions or conditions with respect to the exercisability
thereof, including all Series A Conversion Shares. 
 GAAP: shall have the meaning set forth in Section 3.7(b). 

Governmental Authority: shall mean any governmental department, commission, board, bureau, agency, court or other instrumentality,
whether foreign or domestic, of any country, nation, republic, federation or similar entity or any state, county parish or municipality, jurisdiction or other political subdivision thereof or any self-regulatory organization. 

Hazardous Materials: shall mean (i) any substance that is listed, classified or regulated under any Environmental Laws;
(ii) any petroleum product or by-product, asbestos-containing material, lead-containing paint or plumbing, polychlorinated biphenyls, radioactive material, molds, or radon; or (iii) any other substance that is the subject of regulatory
action, or that could give rise to liability, under any Environmental Laws. 
 Indemnification Agreement: shall mean an
indemnification agreement between the Company and a director of the Company, substantially in the form of Exhibit G. 

Indebtedness: shall mean, without duplication, (A) all indebtedness for borrowed money, (B) all obligations issued,
undertaken or assumed as the deferred purchase price of property or services, including, without limitation, “capital leases” in accordance with GAAP (other than trade payables entered into in the ordinary course of business), (C) all
reimbursement or payment obligations with respect to letters of credit, surety bonds and other similar instruments, (D) all obligations evidenced by notes, bonds, debentures or similar instruments, including obligations so evidenced incurred in
connection with the acquisition of property, assets or businesses, (E) all indebtedness created or arising under any conditional sale or other title retention agreement, or incurred as financing, in either case with respect to any property or
assets acquired with the proceeds of such indebtedness (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession or sale of such property), (F) all monetary obligations
under any leasing or similar arrangement which, in connection with GAAP, consistently applied for the periods covered thereby, is classified as a capital lease, (G) all indebtedness referred to in clauses (A) through (F) above secured
by (or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any Lien upon or in any property or assets (including accounts and contract rights) owned by any person, even though the person which
owns such assets or property has not assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in respect of indebtedness or obligations of others of the kinds referred to in clauses (A) through
(G) above. 
 Indemnified Party: shall have the meaning set forth in Section 5.3(a). 

Indemnified Parties: shall have the meaning set forth in Section 5.3(a). 

  
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 Independent Director: shall mean an individual who, as a member of the Board following the
Closing Date, is not a Purchaser Designee. 
 Intellectual Property: shall mean (i) trademarks, service marks, brand names,
certification marks, trade dress, domain names and other indications of origin, the goodwill associated with the foregoing and registrations in any jurisdiction of, and applications in any jurisdiction to register, the foregoing, including any
extension, modification or renewal of any such registration or application, (ii) inventions, processes, improvements, discoveries, ideas, know-how, research and development, formula methodology, and technology, whether patentable or not, in any
jurisdiction, patents, applications for patents (including divisions, continuations, continuations in part and renewal applications), and any renewals, extensions or reissues thereof, in any jurisdiction, (iii) trade secrets, including
confidential information and the right in any jurisdiction to limit the use or disclosure thereof, (iv) writings and other works, whether copyrightable or not, in any jurisdiction, and any and all copyright rights, whether registered or not,
and registrations or applications for registration of copyrights in any jurisdiction, and any renewals or extensions thereof, (v) moral rights, database rights, design rights, industrial property rights, publicity rights and privacy rights,
(vi) Web domain names and applications and registrations pertaining thereto; (vii) rights under all agreements relating to the foregoing, (viii) books and records relating to the foregoing, and (ix) any similar intellectual
property or proprietary rights. 
 Issuer Covered Person: shall have the meaning set forth in Section 3.24(b). 

Liens: shall mean any charge, claim, community property interest, condition, equitable interest, lien, mortgage, option, pledge,
security interest, indenture, hypothecation, deed of trust, right of first refusal, easement, security agreement, or restriction of any kind, including any restriction or limitation on use, voting, transfer, receipt of income, or exercise of any
other attribute of ownership. 
 Losses: shall have the meaning set forth in Section 5.3(a). 

Material Adverse Effect: shall mean any effect, change, event, occurrence, condition, circumstance or development (each, a
“Change,” and collectively, “Changes”) that individually or in the aggregate (a) was or would reasonably be expected to be materially adverse to the business, condition (financial or otherwise), assets,
liabilities, properties or results of operations of the Company and its Subsidiaries, taken as a whole, provided, however, that in determining whether a Material Adverse Effect has occurred under clause (a), any Change shall be excluded to the
extent that it occurs after the date of this Agreement and results from (i) changes in GAAP, (ii) general changes in the economy or the industries in which the Company and its Subsidiaries operate, (iii) any acts of war, terrorism,
insurrection or civil disobedience, (iv) any change in law applicable to the Company or Subsidiaries (not including any changes in healthcare laws, rules and regulations), (v) actions or omissions of the Company expressly required by the
terms of this Agreement or taken with the prior written consent of the Purchasers, (vi) changes in the market price or trading volumes of the Common Stock or the Company’s other securities (it being understood that this clause
(vi) shall not prevent a party from asserting that any Change that may have contributed to such change contemplated in this clause (vi) constitutes or contributes to a Material Adverse Effect) or (vii) the failure of the Company to
meet any internal or public projections, forecasts, estimates or guidance (but not the underlying causes of such failure), in each case, to the extent that such circumstances, events, changes, developments or effects described in any of the
foregoing clauses (i), (ii), (iii) or (iv) do not have a disproportionate effect on the Company and its Subsidiaries, taken as a whole (relative to other participants in the industries, markets or geographic areas in which the Company and
its Subsidiaries compete); or (b) would prevent or materially delay the consummation of the transactions contemplated by this Agreement and the Transaction Documents. 

  
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 Material Closing Date Contracts: shall have the meaning set forth in Section 3.15(b).

 Material Licenses: shall have the meaning set forth in Section 3.9(d). 

Material Signing Date Contracts: shall have the meaning set forth in Section 3.15(a). 

Medical JV: shall mean Milestone Medical Inc., a Delaware corporation in which the Company currently holds a 45.5% equity
interest. 
 New Equity Securities: shall mean (i) Common Stock, (ii) securities convertible into or exchangeable for
Common Stock, or (iii) securities convertible into or exercisable for such convertible or exchangeable securities, including without limitations preferred stock, rights, options or warrants to purchase such securities solely for cash and not
pursuant to a Special Registration; provided, however, that none of the following offerings shall constitute a Subject Equity Offering: (i) any offering pursuant to any present or future plan providing for the reinvestment of
dividends or interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common Stock under any such plan, approved by the Board of Directors; (ii) any offering pursuant to any present or
future employee, director or consultant benefit, agreement, plan or program of, or assumed by, the Company or any of its Subsidiaries, approved by the Board, including any stock purchase plan, stock ownership plan, stock option plan or other similar
plan where stock is being issued or offered to a trust, other entity or otherwise, to or for the benefit of any employees, directors, officers or consultants of the Company, (iii) any offering made pursuant to any merger, joint venture,
partnership, share exchange, business combination or similar transaction or any other direct or indirect acquisition by the Company, whereby the Company’s securities comprise, in whole or in part, the consideration paid by the Company in such
transaction, (iv) the issuance of Common Stock on conversion of any Preference Stock (as defined in the Certificate of Designation), (v) the issuance of Common Stock, Options or Convertible Securities in connection with the conversion or
exercise of Options or Convertible Securities of the Company outstanding on the date hereof (as disclosed in Section 3.3(a)) or issued in accordance with Section 5.1, (vi) pursuant to any dividend or distribution
pursuant to Section 3 of the Certificate of Designation or a dividend equivalent on any other class or series of capital stock, (vii) any offering made to banks, equipment lessors or other lenders, or to real property lessors, in each
case, in connection with a debt financing (limited to secured or unsecured debt for borrowed money that is not pursuant to the issuance of Convertible Securities), equipment leasing or real property leasing transaction, provided such transaction was
approved by the Board of Directors; (viii) any offering made to suppliers or third party service providers who are not Affiliates of the Company, in each case, in connection with the provision of goods or services on terms and conditions
approved by the Board of Directors; and (ix) any offering made to third parties who are not Affiliates of the Company in connection with sponsored research, collaboration, technology license, development, OEM, marketing or other similar
agreements or strategic partnerships, in each case, on terms and conditions approved by the Board of Directors of the Company. 

  
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 Organizational Documents: shall mean the Certificate of Incorporation and the Bylaws. 

Permits: shall have the meaning set forth in Section 3.9(d). 

Person: shall mean an individual, corporation, general partnership, limited partnership, limited liability partnership, joint venture,
association, joint-stock company, trust, limited liability company, unincorporated organization, other entity or government or any agency or political subdivision thereof. 

Private Placement: shall have the meaning set forth in Section 5.1(b)(ii). 

Purchaser and Purchasers: shall have the meaning set forth in the Preamble. 

Purchaser Designee(s): shall have the meaning set forth in Section 5.13(a). 

Purchaser Group: shall mean Innovest and any Affiliate of Innovest other than any “portfolio company” (as such term is
customarily used among private equity investors) of any of the foregoing. 
 Purchaser Percentage Interest: shall mean, with respect
to a Purchaser, the percentage of Total Voting Power, determined on the basis of the number of Voting Securities on a Fully Diluted Basis, that is Beneficially Owned by the such Purchaser or Purchaser Group, as the case may be. 

Reference SEC Reports: Company SEC Reports filed with or furnished to the SEC on or after January 1, 2014 and prior to the date
hereof and publicly available (without giving effect to any amendment to any such Company SEC Reports filed on or after the date hereof and excluding any disclosures that constitute general cautionary, predictive or forward-looking statements set
forth in any section of a Company SEC Report entitled “Risk Factors” or “Forward-Looking Statements” or any other sections of such filings). 

Registration Rights Agreement: shall have the meaning set forth in Section 6.1(f). 

Release: shall mean any actual or threatened release, spill, emission, leaking, dumping, injection, pouring, deposit, disposal,
discharge, dispersal, leaching or migration into the environment. 
 Representatives: shall mean the officers, directors, agents,
members, partners, employees or Affiliates of a Person. 

  
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 Rule 16b-3: shall have the meaning set forth in Section 5.7(a). 

Rule 144A: shall mean Rule 144A under the Securities Act or any successor or similar rule as may be enacted by the SEC from time to
time, as in effect from time to time. 
 Sarbanes-Oxley Act: shall mean the Sarbanes-Oxley Act of 2002, as amended, and the rules and
regulations promulgated thereunder. 
 SEC: shall mean the Securities and Exchange Commission. 

Section 16(b) Period: shall have the meaning set forth by Section 5.7(b). 

Securities: shall have the meaning set forth in Section 2.1. 

Securities Act: shall mean the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

Series A Conversion Shares: shall mean shares of Common Stock issuable upon conversion of Series A Preferred Stock. 

Series A Preferred Certificate of Designation: shall have the meaning set forth in Section 1. 

Series A Preferred Stock: shall have the meaning set forth in Section 1. 

Special Registration: shall mean the registration of (i) equity securities and/or options or other rights in respect thereof
solely registered on Form S-4 or Form S-8 (or successor form) or (ii) shares of equity securities and/or options or other rights in respect thereof to be offered to customers, lenders or vendors of the Company or its direct or indirect
Subsidiaries or in connection with dividend reinvestment plans. 
 Subject Equity Offering: shall mean (i) a public or nonpublic
offering by the Company to all of its stockholders of any New Equity Securities, or (ii) a proposed issuance of New Equity Securities to any existing or new investor in the Company in a private placement, direct registered sale, PIPE or other
“off-market” transaction . 
 Subsidiary: shall mean a partnership, joint-stock company, corporation, limited liability
company, trust, unincorporated organization or other entity of which a Person owns, directly or indirectly, more than 50% of the stock or other interests the holder of which is generally entitled to vote for the election of the board of directors or
other governing body of such entity. 
 Takeover Provisions: shall have the meaning set forth in Section 5.6. 

Total Voting Power: shall mean at any time the total combined voting power in the general election of directors of all the Voting
Securities then outstanding. 

  
 - 43 - 

 Transaction Documents: shall mean the Registration Rights Agreement and the Series A
Preferred Certificate of Designation. 
 Transfer: shall mean any sale, assignment, pledge, transfer, hypothecation, short sale,
grant any option for the purchase of, or other disposition. 
 Voting Securities: shall mean, at any time, shares of any class of
equity securities of the Company which are then entitled to vote generally in the election of directors. 
 7.2. Accounting
Principles. 
 Where the character or amount of any asset or amount of any asset or liability or item of income or expense is required to
be determined or any consolidation or other accounting computation is required to be made for the purposes of this Agreement, this shall be done in accordance with GAAP at the time in effect, to the extent applicable, except where such principles
are inconsistent with the requirements of this Agreement. 
 7.3. Governing Law. 

This Agreement shall be governed by and construed in accordance with the laws of the State of New York without giving effect to any contrary
result otherwise required by conflict or choice of law rules. 
 7.4. Paragraph and Section Headings. 

The headings of the sections and subsections of this Agreement are inserted for convenience only and shall not be deemed to constitute a part
thereof. 
 SECTION 8. COVENANTS OF THE COMPANY PRIOR TO CLOSING DATE 

8.1. Access. 
 Between the
date of this Agreement and the Closing Date, the Company will (a) afford Purchasers reasonable access on prior notice to the Company’s personnel, properties, contracts, books and records, and other documents and data, and (b) without
the necessity of creating it solely for Purchasers, furnish Buyer and Buyer’s Advisors with such additional financial, operating, and other data and information as Buyer may reasonably request. 

8.2. Operation of the Business. 

Between the date of this Agreement and the Closing Date, the Company will, and will cause the Medical JV to: 

(a) conduct its business only in the ordinary course, meaning consistently with past practice and in the ordinary course of normal day-to-day
operations (except for such plans and activities in process set forth in the Disclosure Schedules); 

  
 - 44 - 

 (b) use reasonable commercial efforts to preserve intact its current business organization, keep
available the services of its current officers and employees and maintain its relations and good will with suppliers, customers, landlords, creditors, employees, agents, and others having business relationships with it, but shall not be required to
change its business practices or incur any material expense other than in the ordinary course of business; and 
 (c) confer with the
Purchasers concerning operational matters of a material nature. 
 8.3. Negative Covenant. 

Except as otherwise expressly permitted by this Agreement (including the plans and activities in process set forth in the Disclosure
Schedules), between the date of this Agreement and the Closing Date, the Company will not, and will cause the Medical JV not to, without the prior consent of the Purchasers, take any affirmative action, or fail to take any reasonable action within
their or its control, as a result of which any of the changes or events listed in Sections 3.8 is likely to occur. 
 8.4.
Notification. 
 Between the date of this Agreement and the Closing Date, the Company will promptly notify the Purchasers in writing
if the Company or the Medical JV becomes aware of any fact or condition that causes or constitutes a breach of any of the Company’s representations and warranties as of the date of this Agreement. During the same period, the Company will
promptly notify the Purchasers of the occurrence of any breach of any covenant in this Section 8 or of the occurrence of any event that may make the satisfaction of the conditions in Section 6 impossible or unlikely. 

8.5. No Negotiation. 
 The
Company will not, and will cause the Medical JV not to, directly or indirectly solicit, initiate, or encourage any inquiries or proposals from, any person (other than the Purchasers) relating to any transaction involving the sale of the business or
assets (other than inventory in the ordinary course of business), or any merger, consolidation, business combination, or similar transaction, except as is in process or otherwise contemplated by this Agreement. 

SECTION 9. MISCELLANEOUS 
 9.1.
Notices. 
 (a) All communications under this Agreement shall be in writing and shall be delivered by hand or facsimile or mailed by
overnight courier or by registered mail or certified mail, postage prepaid: 
 (1) if to Purchasers at: BP4 S.p.A., c/o
Innovest S.p.A., Corso Venezia 44 

  
 - 45 - 

 Milano, Italy 20121 (facsimile: +39 02 231 61949), Attention: GianDomenico Trombetta, CEO, or at such other
address or facsimile number as the Purchasers may have furnished the Company in writing, with a copy to Goodwin Procter LLP, 53 State Street, Boston, Massachusetts 02109 (facsimile: (617) 523-1231), Attention: Ettore A. Santucci, Esq.; and 

(2) if to the Company, at: Milestone Scientific Inc., 220 South Orange Avenue, Livingston, New Jersey 07039 (facsimile:
(973) 535-2829), Attention: Chief Executive Officer, or at such other address or facsimile number as it may have furnished the Purchasers in writing, with a copy to Golenbock Eiseman Assor Bell & Peskoe LLP, 437 Madison Avenue, New
York, NY (facsimile: (212) 754-0330), Attention: Lawrence Bell, Esq. 
 (b) Any notice so addressed shall be deemed to be given: if
delivered by hand or facsimile, on the date of such delivery; if delivered by a national overnight courier, on the first Business Day following the date placed with such courier for overnight delivery; and if mailed by registered or certified mail,
on the third Business Day after the date of such mailing. 
 9.2. Expenses. 

(a) Each party shall pay its own expenses incurred by it in connection with transactions contemplated hereby and the Transaction Documents,
including fees and disbursements of legal counsel, accountants, advisors and consultants, and such other fees and expenses, including diligence fees and expenses, incurred in connection with the negotiation and execution and deliver of this
Agreement and the Transaction Documents and any instrument delivered in connection therewith. 
 (b) The Company will pay, and save and hold
the Purchasers harmless from any and all liabilities (including interest and penalties) with respect to, or resulting fro any delay or failure in paying, federal or state (within the United States of America stamp and other taxes (other than income
taxes), if any, which may be payable or determined to be payable on the execution and delivery or acquisition of the Securities by the Purchasers at the Closing. 

9.3. Reproduction of Documents. 

This Agreement and the Transaction Documents and all documents relating thereto, including, without limitation,
(a) consents, waivers and modifications which may hereafter be executed, (b) documents received by a Purchaser on a Closing Date (except for certificates evidencing the Securities themselves), and (c) financial statements,
certificates and other information previously or hereafter furnished to the Purchaser, may be reproduced by the Purchaser by any photographic, photostatic, microfilm, micro-card, miniature photographic or
other similar process and the Purchaser may destroy any original document so reproduced. All parties hereto agree and stipulate that any such reproduction shall be admissible in evidence as the original itself in any judicial or administrative
proceeding (whether or not the original is in existence and whether or not such reproduction was made by a Purchaser in the regular course of business) and that any enlargement, facsimile or further reproduction of such reproduction shall likewise
be admissible in evidence. 

  
 - 46 - 

 9.4. Survival. 

The representations, warranties and covenants made by a Purchaser and the Company herein or in any certificate or other instrument delivered by
a Purchaser or the Company under this Agreement shall be considered to have been relied upon by the Company or such Purchasers, as the case may be, and shall survive delivery to such Purchaser of any of the Securities, or payment to the Company for
such Securities (if any), regardless of any investigation made by the Company or such Purchaser, as the case may be, or on the Company’s or such Purchaser’s behalf until twenty-four (24) months after each Closing; provided,
however, that the representations and warranties set forth in Section 3.1 (Corporate Organization), Section 3.2 (No Subsidiaries), Section 3.3 (Capitalization), Section 3.4 (Authorization), Section 3.5 (No Conflicts),
Section 3.6 (Approvals), Section 3.25 (Investment Banking) and Section 4 (Representations and Warranties of the Purchasers) shall survive each Closing until sixty (60) days following the expiration of any applicable statute of
limitations (including any extensions thereof). Any claims under this Agreement with respect to a breach of a representation and warranty must be asserted by written notice within the applicable survival period contemplated by this Section 8.4,
and if such a notice is given, the survival period for such representation and warranty shall continue until the claim is fully resolved. All statements in any such certificate or other instrument delivered by the Company shall constitute warranties
and representations by the Company hereunder. 
 9.5. Successors and Assigns. 

This Agreement shall inure to the benefit of and be binding upon the successors and assigns of each of the parties as provided below. The
Company may not assign its rights or obligations hereunder without the prior written consent of the Purchasers. A Purchaser may assign their respective rights and obligations hereunder to any of members of its Purchaser Group. In addition, the
Purchasers may assign all, but not less than all, of their rights and obligations hereunder to any Person at any time without the need to any consent from the Company or any other Purchaser, provided that in connection with any such
assignment, the Purchaser Group shall Transfer any Securities then owned by the Purchaser Group to such Person. 
 9.6. Entire Agreement;
Amendment and Waiver. 
 This Agreement and the Transaction Documents and the other agreements contemplated hereby and thereby constitute
the entire understandings of the parties hereto and supersede all prior agreements or understandings with respect to the subject matter hereof among such parties. This Agreement may be amended, and the observance of any term of this Agreement may be
waived, with (and only with) the written consent of the Company (to the extent approved by a majority of Independent Directors) and the Purchasers. 

9.7. Severability. 
 In the
event that any part or parts of this Agreement shall be held illegal or unenforceable by any court or administrative body of competent jurisdiction, such determination shall not affect the remaining provisions of this Agreement which shall remain in
full force and effect. 

  
 - 47 - 

 9.8. Lost Certificates Evidencing Securities; Exchange. 

Upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of any certificate
evidencing any Securities owned by a Purchaser and (in the case of loss, theft or destruction) of an unsecured indemnity satisfactory to it, and upon reimbursement to the Company of all reasonable expenses incidental thereto, and upon surrender and
cancellation of such certificate, if mutilated, the Company will make and deliver in lieu of such certificate a new certificate of like tenor and for the number of securities evidenced by such certificate which remains outstanding. Upon surrender of
any certificate representing any Securities, for exchange at the office of the Company, the Company at its expense will cause to be issued in exchange therefor new certificates in such denomination or denominations as may be requested for the same
aggregate number of Securities represented by the certificate so surrendered and registered as such holder may request. The Company will also pay the cost of all deliveries of certificates for such Securities to the office of a Purchaser upon any
exchange provided for in this Section 8.9. Notwithstanding the foregoing, to the extent any third party engaged as transfer agent for any of the Securities requires an indemnity bond in connection with the issuance of any new or
replacement certificate, such Purchaser will be solely responsible for the costs thereof. 
 9.9. Terms Generally. 

(a) The words “hereby”, “herein”, “hereof”, “hereunder” and words of similar import refer to this
Agreement as a whole and not merely to the specific section, paragraph or clause in which such word appears. All references herein to Articles and Sections shall be deemed references to Articles and Sections of this Agreement unless the context
shall otherwise require. The words “include”, “includes” and “including” shall be deemed to be followed by the phrase “without limitation”. The definitions given for terms in Section 7.1 and
elsewhere in this Agreement shall apply equally to both the singular and plural forms of the terms defined. Whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. References herein to any
agreement or letter shall be deemed references to such agreement or letter as it may be amended, restated or otherwise revised from time to time. 

9.10. Draftsmanship. 

Each of the parties hereto has been represented by its own counsel and acknowledges that it has participated in the drafting of this Agreement
and the Transaction Documents, and any applicable rule of construction to the effect that ambiguities are to be resolved against the drafting party shall not be applied in connection with the construction or interpretation of this Agreement or the
Transaction Documents. Whenever required by the context hereof, the singular number shall include the plural, and vice versa; the masculine gender shall include the feminine and neuter genders; and the neuter gender shall include the masculine and
feminine genders. 

  
 - 48 - 

 9.11. Counterparts. 

This Agreement may be executed in counterparts (including by facsimile), each of which shall be deemed an original and all of which together
shall be considered one and the same agreement. 
 9.12. Several and Not Joint. 

The obligations of each Purchaser under this Agreement and the Transaction Documents are several and not joint with the obligations of any
other Purchaser, and no Purchaser shall be responsible in any way for the performance of the obligations of any other Purchaser under this Agreement or any Transaction Document. The failure or waiver of performance under this Agreement or any
Transaction Document by any Purchaser shall not excuse performance by any other Purchaser. Nothing contained herein or in any other Transaction Document, and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed to constitute
the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions
contemplated by this Agreement or the Transaction Documents. Each Purchaser shall be entitled to independently protect and enforce its rights, including without limitation, the rights arising out of this Agreement or out of the other Transaction
Documents to which it is a party, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding for such purpose. 

9.13. Specific Performance. 

The parties acknowledge and agree that irreparable damage would result in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that each party shall be entitled to an injunction or other equitable relief, without the necessity of posting a bond, to prevent or cure breaches
of the provisions of this Agreement and to enforce specifically the terms and provisions thereof, this being in addition to any other remedy to which the parties may be entitled by law or equity. 

  
 - 49 - 

 9.14. No Recourse. 

Notwithstanding that each Purchaser is a partnership or limited liability company, (a) no recourse hereunder or under any Transaction
Document shall be had against any former, current, or future general or limited partners, stockholders, managers, members, directors, officers, Affiliates or agents of a Purchaser, whether by the enforcement of any judgment or assessment or by any
legal or equitable proceeding, and (b) no personal liability whatsoever will attach to, be imposed on or otherwise incurred by any of the foregoing persons under this Agreement or any other Transaction Document or for any claim based on, in
respect of, or by reason of such obligations hereunder or by their creation or any failure or alleged failure to perform such obligations. As used in this Section 8.15, a “Related Party” of a Person shall mean any former,
current or future controlling person, director, officer, employee, agent, general or limited partner, manager, member, affiliate, stockholder, assignee or representative of such Person or any of its successors or permitted assigns or any former,
current or future controlling person, director, officer, employee, agent, general or limited partner, manager, member, affiliate, stockholder, assignee or representative of any of the foregoing. Nothing contained in this Section 9.14 is
intended to waive any recourse against the Purchaser Designee or other designee or appointee of the Purchasers with respect to the fiduciary duties they may have as a Member of the Board of Directors or as an officer or employee of the Company or
any Subsidiary or business unit thereof, including without limitation, the duty of confidentiality. 
 [SIGNATURE PAGE FOLLOWS] 

  
 - 50 - 

 
			
	Very truly yours,
	
	MILESTONE SCIENTIFIC INC.
		
	By:	 	/s/ Leonard Osser
		 	Name: Leonard Osser
		 	Title: President

  

			
	ACCEPTED AND AGREED:
	
	BP4 S.p.A.
		
	By:	 	/s/ Giandomenico Trombetta
	Name: Giandomenico Trombetta
	Title: Sole Director

 Signature Page to Investment Agreement 

 Schedule 2.1 

Closing 
  

																					
	 Purchaser
	  	Number of
Common Stock	 	  	Purchase
Price Per
Share	 	  	Number of
Series A
Convertible
Preferred
Stock	 	  	Purchase
Price Per
Share	 	  	Aggregate
Purchase
Price	 
	 BP4 S.p.A., an Italian corporation with no office in the United States
	  	 	2,000,000 shares	  	  	$	1.50	  	  	 	7,000 shares	  	  	$	1,000	  	  	$	10,000,000EX-10.2

 Exhibit 10.2 

CERTIFICATE OF DESIGNATION 

OF 
 SERIES A
CONVERTIBLE PREFERRED STOCK 
 OF 

MILESTONE SCIENTIFIC INC. 
  

 
 Pursuant to
Section 151 of the General 
 Corporation Law of the State of Delaware 

 
  

Milestone Scientific, Inc. (the “Company”), a corporation organized and existing under and by virtue of the General
Corporation Law of the State of Delaware (the “DGCL”), hereby certifies as follows: 
 FIRST: The Certificate of
Incorporation (the “Certificate of Incorporation”) of the Company authorizes the issuance of up to 5,000,000 shares of preferred stock, par value $0.001 per share (the “Authorized Preferred Stock”), and further
authorizes the Board of Directors of the Company by resolution or resolutions to provide for the issuance of Authorized Preferred Stock in series and to establish the number of shares to be included in each such series and to fix the designation,
powers, preferences and relative rights and qualifications, limitations or restrictions of each such series. 
 SECOND: On April
    , 2014, the Board of Directors of the Company adopted the following resolution authorizing the creation and issuance of a series of said Authorized Preferred Stock to be known as “Series A Convertible Preferred
Stock”: 
 RESOLVED: that, pursuant to authority conferred upon the Board of Directors by the Certificate of Incorporation of the
Company, the Board of Directors hereby authorizes and establishes a series of 7,000 shares of Series A Convertible Preferred Stock, and hereby fixes the number, designation, powers, preferences and relative, participating, optional or other special
rights, and the qualifications, limitations or restrictions thereof, of such shares as follows: 
 1. Designation and Amount. 

(a) There shall be created from the Authorized Preferred Stock a series of preferred stock, designated as the “Series A
Convertible Preferred Stock,” par value $0.001 per share (the “Series A Preferred Stock”), and the authorized number of shares of such series shall be 7,000, which may be issued by the Company from time to time subject to
compliance with this Certificate, the Investment Agreement (as defined in Annex I, attached hereto) and any other conditions to issuance. 

 (b) The Series A Preferred Stock shall have the voting powers, designations,
preferences and other special rights, and qualifications, limitations and restrictions set forth in Annex I, attached hereto. 
 IN WITNESS WHEREOF, the
Company has caused this Certificate of Designation to be signed this             day of April, 2014. 

 

			
	MILESTONE SCIENTIFIC INC.
		
	By:	 	 
		 	Name:
		 	Title:

  
 - 2 - 

 ANNEX I 

ADDITIONAL TERMS 
 OF

 SERIES A CONVERTIBLE PREFERRED STOCK 

OF 
 MILESTONE SCIENTIFIC
INC. 
 2. Definitions. As used herein, the following terms shall have the following meanings: 

(a) “Acquiring Person” shall mean any Person or group (within the meaning of Section 13(d)(3) of the
Exchange Act) (other than any Person who is a member of the Investor Group or an Affiliate thereof). 
 (b)
“Affiliate” shall mean any Person, directly or indirectly, controlling, controlled by or under common control with such Person. 

(c) “Applicable Issuance Date” means the date of the issuance of the applicable shares of Series A Preferred
Stock (which may be issued from time to time on one or more days). 
 (d) “Applicable Terms” means any of
the following defined terms herein: (i) Optional Conversion Price; (ii) Forced Conversion Price; (iii) Stated Value; and (iv) Threshold Price. 

(e) “Approved Markets” shall mean the NASDAQ Global Select Market, the NASDAQ Global Market, the NASDAQ
Capital Market, NYSE Amex, or the NYSE. 
 (f) “Authorized Preferred Stock” has the meaning set forth in the
recitals. 
 (g) “Base Conversion Price” means $2.545, subject to adjustment as set forth in Section 8,
if both of the following conditions have been met: 
 (i) the Closing Price per share of the Common Stock for any forty (40) Trading
Days (which need not be consecutive) during the 360 calendar day period immediately prior to the fifth anniversary of the Original Issue Date is equal to or greater than the Threshold Price, and 

(ii) the daily trading volume of Common Stock is not less than 10,000 shares on each of the forty (40) Trading Days used in clause
(i) above. 

  
 Annex I-1 

 (h) “Board of Directors” means the Board of Directors of the
Company or, with respect to any action to be taken by the Board of Directors, any committee of the Board of Directors duly authorized to take such action. 

(i) “Business Day” means any day except Saturday, Sunday and any day which shall be a legal holiday or a day
on which banking institutions in the State of New York generally are authorized or required by law or other governmental actions to close. 

(j) “Capital Stock” of any Person means any and all securities (including equity-linked securities), interests
(including partnership interests), rights to purchase, warrants, options, participations or other equivalents of or interests in (however designated) equity of such Person, including any Preference Stock. 

(k) “Certificate” means this Certificate of Designation with respect to the Series A Preferred Stock, as
amended from time to time. 
 (l) “Certificate of Incorporation” has the meaning set forth in the recitals.

 (m) “Closing Price” shall mean, on any date of determination, (i) if the Common Stock is listed on
an Approved Market, the most recent consolidated closing bid price or, if no such closing bid price is reported, the last reported bid price of the shares of the Common Stock on the relevant Approved Market on such date; (ii) if the Common
Stock is not traded on an Approved Market on any date of determination, the closing bid price as reported in the composite transactions for the principal U.S. national or regional securities exchange on which the Common Stock is so listed or quoted,
or, if no closing bid price is reported, the last reported bid price on the principal U.S. national or regional securities exchange on which the Common Stock is so listed or quoted, or (iii) if the Common Stock is not so listed or quoted on any
U.S. national or regional securities exchange, the last quoted bid price for the Common Stock in the over-the-counter market as reported by Pink Sheets LLC or similar organization, or, (iv) if that bid price is not available, the market price
of the Common Stock on that date will be the average of the mid-point of the last bid and ask prices for such stock from each of three nationally recognized independent investment banking firms, one selected by the Company, one selected by the
Investor Group, and the third selected by those two firms. 
 (n) “Common Stock” means the common stock, par
value $0.001 per share, of the Company, or any other class of stock resulting from successive changes or reclassifications of such Common Stock consisting solely of changes in par value, or from par value to no par value, or as a result of a
subdivision, combination or merger, reclassification, consolidation or similar transaction in which the Company is a constituent corporation. 

(o) “Company” has the meaning set forth in the recitals. 

(p) “Contingent Conversion price” means $1.50, subject to adjustment as set forth in Section 8 hereof. 

(q) “Conversion Date” has the meaning set forth in Section 7(a)(iv). 

  
 Annex I-2 

 (r) “Conversion Price” means the Optional Conversion Price or
the Forced Conversion Price, as applicable. 
 (s) “Conversion Right” has the meaning set forth in
Section 7(a)(i). 
 (t) “Conversion Right Notice” has the meaning set forth in Section 7(a)(ii).

 (u) “Convertible Securities” means debt securities or shares of Capital Stock, in each case convertible
into or exchangeable, directly or indirectly, for Common Stock. 
 (v) “Current Market Price” means, on any
date, the average of the daily Closing Price per share of the Common Stock or other securities on each of the twenty (20) consecutive Trading Days preceding the earlier of the day before the date in question and the day before the Ex-Date with
respect to the issuance or distribution giving rise to an adjustment to the Conversion Price pursuant to Section 8. 

(w) “DGCL” has the meaning set forth in the recitals. 

(x) “Deemed Liquidation” means the consummation of any transaction or series of related transactions
(i) involving any sale, lease, exchange, transfer, exclusive license or disposition of all or substantially all of the assets of the Company and its Subsidiaries, taken together as a whole, to an Acquiring Person, or (ii) involving any
merger, consolidation or business combination in which the holders of voting securities of the Company immediately prior to the transaction, as a group, do not hold securities representing a majority of the outstanding voting power entitled to elect
the board of directors of the surviving entity in such merger, consolidation or business combination. 
 (y) “Dental
Company” means a future entity separate from the Company to which all or substantially all assets comprising the Company’s current dental business are transferred. 

(z) “Dividend Equivalent Amount” has the meaning set forth in Section 3(d). 

(aa) “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations
promulgated thereunder. 
 (bb) “Ex-Date”, when used with respect to any issuance or distribution, means the
first date on which the Common Stock or other securities trade without the right to receive the issuance or distribution giving rise to an adjustment to the Conversion Price pursuant to Section 8. 

(cc) “Forced Conversion Price” means the Base Conversion Price or the Contingent Conversion Price, as
applicable. 
 (dd) “GAAP” means United States generally accepted accounting principles. 

  
 Annex I-3 

 (ee) “Holder” means a holder of record of outstanding shares of
the Series A Preferred Stock. 
 (ff) “Investment Agreement” means that certain Investment Agreement, dated
April [_], 2014, by and among the Company and the purchasers named therein, as the same may be amended from time to time. 

(gg) “Investor Group” means, collectively, Innovest Spa, BP4 Spa and their respective Affiliates other than
any of their Affiliates that is a “portfolio company” (as such term is customarily used among private equity investors). 

(hh) “Junior Stock” means all classes of Common Stock and each other class of Capital Stock or series of
preferred stock of the Company established after the Original Issue Date by the Board of Directors, the terms of which do not expressly provide that such class or series ranks senior to or on parity with the Series A Preferred Stock as to rights
upon a Liquidation, Deemed Liquidation or redemption in the event of a deemed liquidation (defined by analogy to the definition of Deemed Liquidation herein). 

(ii) “Junior Stock Event” has the meaning set forth in Section 3. 

(jj) “Liquidation” means the voluntary or involuntary liquidation, dissolution or winding-up of the Company
other than a Deemed Liquidation. 
 (kk) “Liquidation Event” has the meaning set forth in Section 4(a).

 (ll) “Liquidation Preference” has the meaning set forth in Section 4(a). 

(mm) “Mandatory Conversion” has the meaning set forth in Section 7(b)(i). 

(nn) “Mandatory Conversion Time” means the Business Day immediately preceding the fifth anniversary of the
Original Issue Date. 
 (oo) “Medical JV” means Milestone Medical Inc., a Delaware corporation in which the
Company currently holds a 45% equity interest. 
 (pp) “Option” means rights, options or warrants to
subscribe for, purchase or otherwise acquire Common Stock or Convertible Securities. 
 (qq) “Optional Conversion
Price” means $2.545, subject to adjustment as set forth in Section 8 hereof. 
 (rr) “Original Issue
Date” means [            ], 2014. 
 (ss)
“Parity Stock” means any class of Capital Stock or series of preferred stock established after the Original Issue Date by the Board of Directors, the terms of which (i) expressly provide that such class or series will rank on
parity with the Series A Preferred Stock as to rights upon a Liquidation, Deemed Liquidation or redemption in the event of a deemed liquidation (defined by analogy to the definition of Deemed Liquidation herein) or (ii) provide for the payment
of dividends unless the Series A Preferred Stock shall have the right or is simultaneously given the right to participate therein in accordance with Sections 3 and 5(b)(vi) hereof. 

  
 Annex I-4 

 (tt) “Person” means any individual, corporation, general
partnership, limited partnership, limited liability partnership, joint venture, association, joint-stock company, trust, limited liability company, unincorporated organization, other entity or government or any agency or political subdivision
thereof. 
 (uu) “Preference Stock” means, as applied to the Capital Stock of any Person, Capital Stock of
any series, class or classes (however designated) which is preferred as to the payment of dividends or distributions, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of such Person or Deemed
Liquidation of such Person, over shares of Capital Stock of any other series or class of such Person. 
 (vv)
“Qualified Equity Offering” means an offering of shares of Common Stock or Preference Stock of the Company issued in compliance with the rights of the holders of the Series A Preferred Stock if (i) the price per share at which
Common Stock is sold, or the common-stock equivalent purchase price per share if the offering relates to convertible Preference Stock is at least equal to the Optional Conversion Price as in effect at the time and (ii) the gross proceeds to the
Company from the offering are at least $5 million. 
 (ww) “Record Date” means the applicable record date as
determined in accordance with Section 213 of the DGCL. 
 (xx) “Register” has the meaning set forth in
Section 3(a). 
 (yy) “Registration Rights Agreement” means that certain Registration Rights Agreement,
dated April [    ], 2014, between the Company and the signatories thereto relating to the Series A Preferred Stock , as the same may be amended from time to time. 

(zz) “Required Holders” means as of any date the Holders of more than 50% of the then-outstanding shares of
Series A Preferred Stock, voting together as a single class. 
 (aaa) “Senior Stock” means each class of
Capital Stock or series of preferred stock established after the Original Issue Date by the Board of Directors, the terms of which (i) expressly provide that such class or series will rank senior to the Series A Preferred Stock as to rights
upon a Liquidation, Deemed Liquidation or redemption in the event of a deemed liquidation (defined by analogy to the definition of Deemed Liquidation herein) or (ii) provide for the payment of dividends unless the Series A Preferred Stock shall
have the right or is simultaneously given the right to participate therein in accordance with Sections 3 and 5(b)(vi) hereof. 

(bbb) “Series A Preferred Stock” has the meaning set forth in Section 1(a). 

  
 Annex I-5 

 (ccc) “Specified Matters” shall mean all proposals (whether
received from third parties or developed by the Company’s management) relating to (a) investments in debt or equity of another entity, strategic acquisitions or dispositions (including any spin-off of or sale of a minority interest in or
the initial public offering of the Dental Company), and capital expenditures and research and development costs if such expenditures or costs are not funded by third parties, in each case in excess of $500,000 per transaction or series of related
transactions, (b) transactions with Affiliates, (c) issuances of Common Stock, Options, or Convertible Securities, dividends or other distributions on, or repurchases of, Common Stock (other than from employees pursuant to a plan or
agreement approved by the Board of Directors), and (d) appointment of a replacement President/Chief Executive Officer of the Dental Division of the Company in the event of Mr. Trombetta’s resignation. For the avoidance of doubt,
Specified Matters shall not include personnel, compensation, regulatory, compliance or tax matters, including matters customarily within the scope of audit and compensation committees. 

(ddd) “Stated Value” means $1,000.00 per share of Series A Preferred Stock. 

(eee) “Strategic Investment Committee” means a committee consisting of three (3) members as follows:
(i) the Chief Executive Officer of the Company, (ii) the Purchaser Designee (as defined in the Investment Agreement) if a Purchaser Designee is then serving on the Board of Directors, and (iii) a third member who shall be mutually
agreed to in good faith by the Company’s Chief Executive Officer and the Purchaser Designee. The Strategic Investment Committee shall be a committee of the Board of Directors of the Company only if all members thereof shall be members of the
Board of Directors. 
 (fff) “Subsidiary” means (i) a partnership, joint-stock company, corporation,
limited liability company, trust, unincorporated organization or other entity of which a Person owns, directly or indirectly, more than 50% of the stock or other interests the holder of which is generally entitled to vote for the election of the
board of directors or other governing body of such entity, (ii) the Dental Company, or (iii) the Medical JV. 

(ggg) “Threshold Price” means $3.15 per share of Common Stock, as adjusted for stock splits, reverse stock
splits, reclassifications and other like kind events affecting the Common Stock. 
 (hhh) “Trading Day”
means a day during which the trading of securities generally occurs on the Approved Market on which the Common Stock is then listed or, if the Common Stock is not listed on an Approved Market, on NASDAQ. 

(iii) “Transaction” has the meaning set forth in Section 9(d). 

(jjj) “Transfer Agent” means the Company or any duly appointed transfer agent, registrar and conversion and
dividend disbursing agent for the Series A Preferred Stock as may be appointed by the Company from time to time. 

  
 Annex I-6 

 3. Dividends and Distributions. No dividends or other distributions (other than cash paid
in lieu of fractional shares or dividends on Common Stock payable in Common Stock) (a “Junior Stock Event”) may be declared, made or paid, or set apart for payment upon, any Junior Stock, nor may any Junior Stock be redeemed,
purchased or otherwise acquired for any consideration (or any money paid to or made available for a sinking fund for the redemption of any Junior Stock) by or on behalf of the Company or any of its Subsidiaries, unless (a) in the case of a
dividend on Common Stock or any class or series that is convertible into Common Stock, the Holders of Series A Preferred Stock receive, at the same time and upon the same terms, a dividend per share of Series A Preferred Stock as would be payable to
such Holders if such shares of Series A Preferred Stock had been converted into Common Stock, in each case calculated on the record date for determination of holders entitled to receive such dividend at the Optional Conversion Price immediately
prior to the Record Date for such dividend or distribution, or (b) in the case of a dividend on any class or series of Capital Stock that is not convertible into Common Stock, the Holders of Series A Preferred Stock receive at the same time and
upon the same terms a dividend at a rate per share of Series A Preferred Stock determined by (1) dividing the amount of the dividend payable on each share of such class or series of Capital Stock by the original issuance price of such class or
series of Capital Stock (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (2) multiplying such fraction by an amount equal
to the Stated Value; provided that, if the Company declares, pays or sets aside, on the same date, a dividend on shares of more than one class or series of Capital Stock of the Company, the dividend payable to the holders of Series A Preferred Stock
pursuant to this Section 3 shall be calculated based upon the dividend on the class or series of Capital Stock that would result in the highest Series A Preferred Stock dividend. The dividends and distributions described in clauses (a) and
(b) above are referred to herein as the “Dividend Equivalent Amount.” Dividends as provided above shall be paid to the Holders solely as a result of holding Series A Preferred Stock and without having to convert such shares
into Common Stock. For the avoidance of doubt, without duplication, the Series A Preferred Stock shall be entitled to participate as aforesaid on an as-converted basis (using the Optional Conversion Price) in all cash and stock dividends and all
distributions (if any) of (i) options, rights, warrants to subscribe for, purchase or otherwise acquire equity securities, (ii) evidences of indebtedness, (iii) securities or (iv) other assets (if any) made by the Company with
respect to shares of Common Stock. The restrictions set forth in this Section 3 shall not apply to the purchase or other acquisition of Junior Stock (A) pursuant to any bona fide employee, consultant or director incentive or benefit
plan, agreement or arrangement of the Company or any Subsidiary heretofore or hereafter adopted by the Board of Directors or the cashless exercise of Options, (B) repurchases of Capital Stock deemed to occur upon the exercise of Options if the
Capital Stock represents a portion of the exercise price thereof or upon the withholding of a portion of the interests granted or awarded to pay for taxes payable upon such grant or award or the exercise thereof, or (C) which purchase or
acquisition has received the prior written consent of the Required Holders. 

  
 Annex I-7 

	4.	Liquidation; Deemed Liquidation. 

 (a) In the event of any Liquidation (a
“Liquidation Event”), the Holders shall be entitled to be paid out of the assets and funds of the Company available for distribution to its stockholders an amount in cash per each share of Series A Preferred Stock equal to the
greater of (i) 100% of the Stated Value for each share of Series A Preferred Stock outstanding on the date of such Liquidation Event, plus an amount equal to any unpaid Dividend Equivalent Amount as of the date of the Liquidation Event, or
(ii) such amount per share as would have been payable had all shares of Series A Preferred Stock been converted into Common Stock at the Optional Conversion Price immediately prior to such Liquidation Event (the amount payable pursuant to this
sentence is hereafter referred to as the “Liquidation Preference”). Without limiting any rights and remedies of the Holders, if upon any such Liquidation Event, the remaining assets and funds of the Company available for
distribution to its stockholders after payment in full of amounts required to be paid or distributed to holders of Senior Stock are not sufficient to pay in full the liquidation payments payable to the Holders and holders of outstanding shares of
any Parity Stock, then the Holders and holders of all such shares of Parity Stock shall share ratably in such distribution of the remaining assets and funds of the Company in accordance with the amount which would otherwise be payable on such
distribution if the amounts to which the Holders and the holders of outstanding shares of such Parity Stock are entitled were paid in full. 

(b) Unless waived in writing by the Required Holders, in the event of a Deemed Liquidation, each Holder shall have the right in
lieu of the adjustment contemplated by Section 9, at such Holder’s election, to either (i) convert each share of Series A Preferred Stock and receive the amount to which such Holder is entitled to receive upon conversion of such
shares of Series A Preferred Stock into Common Stock at the Optional Conversion Price or (ii) within sixty (60) days of such Deemed Liquidation, or later if the Holders did not receive notice of such Deemed Liquidation, require the Company
to use the consideration received by the Company for such Deemed Liquidation Event (net of any retained liabilities associated with the assets sold or technology licensed, as determined in good faith by the Board of Directors of the Company),
together with any other assets of the Company available for distribution to its stockholders, all to the extent permitted by Delaware law governing distributions to stockholders (the “Available Proceeds”), on the 150th day after
such Deemed Liquidation Event, to redeem, in whole or in part, each share of Series A Preferred Stock held by such Holder for an amount in cash equal to the Liquidation Preference. Unless waived in writing by the Required Holders, the Company shall
not have the power to effect a Deemed Liquidation unless the agreement for such transaction provides that the consideration payable to the stockholders of the Company in such transaction shall be allocated among the holders of capital stock of the
Company in accordance with this Section 4(b). In connection with a redemption permitted above, each Holder shall surrender his, her or its certificate or certificates representing such redeemed shares to the Company, in the manner and at the
place designated in written notice mailed by the Company, postage prepaid, to each Holder, at his, her or its post office address last shown on the Register (which notice shall be given at least ten (10) days prior to such Deemed Liquidation or
such shorter period as may be agreed in writing by the Required Holders), and thereupon the Liquidation Preference of such shares shall be payable to the order of the Person whose name appears on such certificate or certificates as the owner thereof
and each surrendered certificate shall be canceled. From and after the date of redemption, unless there shall have been a default in payment of the Liquidation Preference, all rights of the Holder whose shares have been redeemed (except the right to
receive the Liquidation Preference) shall cease with respect to such shares, and such shares shall not thereafter be transferred on the books of the Company or be deemed to be outstanding for any purpose whatsoever. 

  
 Annex I-8 

 (c) Without limiting any other rights and remedies of the Holders, and
notwithstanding Section 4(b), if upon any such Deemed Liquidation, the Available Proceeds after payment in full of amounts required to be paid or distributed to holders of Senior Stock are not sufficient to pay in full amounts payable to the
Holders and holders of outstanding shares of any Parity Stock, then the holders of all such shares shall share ratably in such distribution of the Available Proceeds in accordance with the amount which would otherwise be payable on such distribution
if the amounts to which the Holders and the holders of outstanding shares of such Parity Stock are entitled were paid in full. 

(d) Unless waived in writing by the Required Holders, written notice of any Liquidation Event or Deemed Liquidation, stating a
payment date and the place where the distributable amounts shall be payable, shall be given no less than ten (10) days prior to the payment date stated therein, to the Holders at their respective addresses as the same shall appear on the
Register. 
 (e) The amount deemed paid or distributed to the holders of Common Stock upon any Liquidation or Deemed
Liquidation shall be the cash or the value of the property, rights or securities paid or distributed to such holders by the Company or the acquiring Person. The value of such property, rights or securities shall be determined in good faith by the
Board of Directors. 
 5. Voting Rights. 

In addition to any voting rights provided by law, the Holders shall be entitled to the following voting rights: 

(a) Each share of Series A Preferred Stock shall entitle the Holder thereof to vote together with the holders of Common Stock
as a single class on all matters submitted for the approval of the holders of Common Stock. For purposes of this Section 5(a), each Holder shall be entitled to the number of votes equal to the number of shares of Common Stock that would be held
by such Holders assuming the conversion of all outstanding shares of Series A Preferred Stock held by such Holder into shares of Common Stock at the Optional Conversion Price on the Record Date for the determination of the stockholders entitled to
vote on such matters. 
 (b) If at any time following the Original Issue Date any shares of Series A Preferred Stock are
outstanding, in addition to any other vote or consent of the stockholders required by law or by the Certificate of Incorporation, including any Certificate of Designation, bylaws of the Company or this Certificate, the Company shall not (whether by
merger, consolidation, reorganization, operation of law or otherwise), without the prior written consent of the Required Holders: 

(i) amend, alter, waive or repeal any provision of its Certificate of Incorporation, including any certificate of designation,
or this Certificate in any manner that adversely affects the rights, powers, or preferences of the Series A Preferred Stock, increase the authorized number of shares of the Series A Preferred Stock; 

(ii) issue any additional shares of Series A Preferred Stock; 

  
 Annex I-9 

 (iii) increase the size of the Board of Directors to more than five
(5) directors; provided that the number of directors of the Company may be increased (x) after the Holders no longer have the right to nominate a Purchaser Designee (as defined in the Investment Agreement) for election to the Board of
Directors, (y) in connection with a Qualified Equity Offering or (z) upon the consent of the Required Holders; 

(iv) issue, or reclassify into, Senior Stock or Parity Stock, including debt securities that are convertible into Capital Stock
by their terms; provided that Preference Stock that has the right to receive dividends may be issued by the Company so long as (x) the Series A Preferred Stock shall have the right or is simultaneously given by a resolution of the Board of
Directors, which will be deemed to amend this Certificate, the right to participate in such dividends in accordance with Section 3 hereof, (y) the right to dividends of such Preference Stock shall rank pari passu with, or junior to,
the right of the Series A Preferred Stock to participate therein, and (z) the terms of such Preference Stock do not expressly provide that it ranks senior to or on parity with the Series A Preferred Stock as to rights upon Liquidation, Deemed
Liquidation or redemption in the event of a deemed liquidation (defined by analogy to the definition of Deemed Liquidation herein); or 

(v) authorize, commit or agree (in writing or otherwise) to do anything contained in this clause (b). 

(c) Any action to be taken at any annual or special meeting of stockholders by the Holders may be taken without a meeting,
without prior notice and without a vote, if a consent or consents in writing, setting forth the action so taken, shall be signed by the Holder or Holders having no less than the minimum number of votes that would be required to take such action at a
meeting at which all of the shares of Series A Preferred Stock were present and voted. Prompt written notice of the taking of any action by the Holders by less than unanimous written consent shall be given as may be required under applicable law.

 6. Redemption. The Company shall have no right to require the redemption of the shares of Series A Preferred Stock. Nothing herein
contained shall prevent or restrict the purchase by the Company, from time to time either at public or private sale, of the whole or any part of the outstanding shares of Series A Preferred Stock at such price or prices as the Company and a Holder
may determine, subject to the provisions of applicable law and obtaining any required consents, including the prior written consent of the Required Holders pursuant to Section 5(b) above. The Holders shall be entitled to require the redemption
of the shares of Series A Preferred Stock as provided in Section 10. 
 7. Conversion. 

(a) Conversion Right. 

(i) Each Holder shall have the right, at such Holder’s option, exercisable at any time and from time to time to convert all or any
portion of such Holder’s shares of Series A Preferred Stock, subject to the terms and provisions of this Section 7 (the “Conversion Right”). Upon a Holder’s election to exercise the Conversion Right, the shares of
Series A Preferred Stock for which the Conversion Right is exercised shall be converted into such whole number of shares of Common Stock equal to the product of the number of shares of Series A Preferred Stock being so converted multiplied by the
quotient of (A) the Stated Value as of the Conversion Date divided by (B) the Optional Conversion Price then in effect. 

  
 Annex I-10 

 (ii) The Conversion Right of a Holder shall be exercised by the Holder by the surrender to the
Company prior to 4:00 p.m. Eastern Time on the Conversion Date of the certificates representing shares of Series A Preferred Stock to be converted (or, if such Holder alleges that such certificate has been lost, stolen or destroyed, a lost
certificate affidavit and agreement reasonably acceptable to the Company to indemnify the Company against any claim that may be made against the Company on account of the alleged loss, theft or destruction of such certificate which agreement shall
not require the posting of a bond) at the Company’s principal place of business or the offices of the Transfer Agent, if applicable, accompanied by written notice to the Company that the Holder elects to convert all or a portion of the shares
of Series A Preferred Stock represented by such certificate (a “Conversion Right Notice”) and specifying the name or names (with address or addresses) in which a certificate or certificates for shares of Common Stock are to be
issued and (if so required by the Company or the Transfer Agent) by a written instrument or instruments of transfer in form reasonably satisfactory to the Company or the Transfer Agent duly executed by the Holder or its legal representative. 

(iii) As promptly as practicable after the surrender of the certificate or certificates for Series A Preferred Stock as aforesaid and the
receipt of the Conversion Right Notice, the Company shall issue and shall deliver or cause to be issued and delivered to such Holder, or to such other Person on such Holder’s written order (A) one or more certificates representing the
number of validly issued, fully paid and non-assessable whole shares of Common Stock to which the Holder, or the Holder’s transferee, shall be entitled, (B) if less than the full number of shares of Series A Preferred Stock evidenced by
the surrendered certificates is being converted, a new certificate or certificates, of like tenor, for the number of shares of Series A Preferred Stock evidenced by the surrendered certificate or certificates, less the number of shares being
converted, (C) cash, securities and/or other property (if and as applicable) representing the Dividend Equivalent Amount for any payment of declared and unpaid dividends through the Conversion Date and (D) cash for any fractional interest
in respect of a share of Common Stock arising upon such conversion settled as provided in Section 7(c)(i). 
 (iv) Each conversion
pursuant to Section 7(a)(i) shall be deemed to have been made at 3:59 p.m. Eastern Time on the date of the later to occur of giving the Conversion Right Notice and of surrendering the certificate or certificates representing the Series A
Preferred Stock to be converted (the “Conversion Date”) so that the rights of the Holder thereof as to the Series A Preferred Stock being converted shall cease except for the right to receive the Common Stock (and cash dividends, if
elected by the Company, and cash in lieu of fractional shares) payable under Section 7(a), and the Person entitled to receive shares of Common Stock shall be treated for all purposes as having become the record holder of those shares of Common
Stock at that time. 

  
 Annex I-11 

 (v) In the event of a notice of redemption of any shares of Series A Preferred Stock pursuant to
Section 4(b) or Section 10, unless waived by the Company, the Conversion Rights of the shares of Series A Preferred Stock designated for redemption shall terminate at the close of business on the last full day preceding the date fixed for
redemption, unless the redemption price is not fully paid on such redemption date, in which case the Conversion Rights for such shares shall continue until such price is paid in full. In the event of Liquidation Event or a Deemed Liquidation Event,
without prejudice to the right of Holders to receive the Liquidation Preference as provided in Section 4, the Conversion Rights shall terminate at the close of business on the last full day preceding the date fixed for the payment of any such
amounts distributable on such event to the holders of Series A Preferred Stock. 
 (b) Mandatory Conversion. 

(i) At the Mandatory Conversion Time each outstanding share of Series A Preferred Stock shall automatically be converted (the
“Mandatory Conversion”) into the whole number of shares of Common Stock equal to the product of the number of shares of Series A Preferred Stock being so converted multiplied by the quotient of (A) the per share Stated Value as
of the Mandatory Conversion Time divided by (B) the Forced Conversion Price then in effect. 
 (ii) All Holders shall be sent written
notice of the Mandatory Conversion Time and the place designated for mandatory conversion of all such shares of Series A Preferred Stock pursuant to this Section 7(b). Promptly following receipt of such notice, each Holder shall surrender his,
her or its certificate or certificates for all such shares (or, if such Holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Company to indemnify the Company
against any claim that may be made against the Company on account of the alleged loss, theft or destruction of such certificate which agreement shall not require the posting of a bond) to the Company at the place designated in such notice. If so
required by the Company, certificates surrendered for conversion shall be endorsed or accompanied by written instrument or instruments of transfer, in form satisfactory to the Company, duly executed by the Holder or by his, her or its attorney duly
authorized in writing. All rights with respect to the Series A Preferred Stock converted pursuant to Section 7(b), including the rights, if any, to receive notices and vote (other than as a holder of Common Stock), will terminate at the
Mandatory Conversion Time (notwithstanding the failure of the Holder or Holders to surrender the certificates at or prior to such time), except only the rights of the Holders, upon surrender of their certificate or certificates (or lost certificate
affidavit and agreement) therefor, to receive the items provided for in the next sentence of this Section 7(b)(ii). As soon as practicable after the Mandatory Conversion Time and the surrender of the certificate or certificates (or lost
certificate affidavit and agreement) for Series A Preferred Stock, the Company shall issue and deliver to such Holder, or to his, her or its nominees, a certificate or certificates for the number of full shares of Common Stock issuable on such
conversion in accordance with the provisions hereof. 
 (c) Miscellaneous. 

(i) No fractional shares of Common Stock shall be issued upon the conversion of any shares of Series A Preferred Stock. If the conversion of
any share or shares of Series A Preferred Stock results in a fractional share of Common Stock issuable, the Company shall pay a cash amount in lieu of issuing such fractional share in an amount equal to such fractional interest multiplied by the
Closing Price of the Common Stock on the Conversion Date or date of the Mandatory Conversion Time, as applicable. Whether or not fractional shares would be issuable upon such conversion shall be determined on the basis of the total number of shares
of Series A Preferred Stock the Holder is at the time converting into Common Stock and the aggregate number of shares of Common Stock issuable upon such conversion. 

  
 Annex I-12 

 (ii) The Company shall reserve and keep available for issuance such number of its authorized but
unissued shares of Common Stock equal to 100% of the number of shares of Common Stock issuable upon conversion of all outstanding shares of Series A Preferred Stock. The Company shall take all action permitted by law to increase the authorized
number of shares of Common Stock if at any time there shall be insufficient authorized but unissued shares of Common Stock to permit such reservation or to permit the conversion of all outstanding shares of Series A Preferred Stock. The Company
covenants that all Common Stock that may be issued upon conversion of Series A Preferred Stock shall upon issuance be duly authorized, fully paid and non-assessable, free and clear of all liens, claims, security interests and other encumbrances.

 (iii) The issuance or delivery of certificates for Common Stock upon the conversion of shares of Series A Preferred Stock pursuant to
this Section 7 shall be made without charge to the converting Holder for such certificates or for any stamp or similar tax in respect of the issuance or delivery of such certificates or the securities represented thereby, and such certificates
shall be issued or delivered in the respective names of, or in such names as may be directed by, the Holders of the shares converted, subject to applicable law. The Company shall not, however, be required to pay any tax which may be payable in
respect of any transfer involved in the issuance and delivery of shares of Common Stock in a name other than that in which the shares of Series A Preferred Stock so converted were registered, and no such issuance or delivery shall be made unless and
until the person or entity requesting such issuance has paid to the Company the amount of any such tax or has established, to the satisfaction of the Company, that such tax has been paid. 

8. Adjustment of Conversion Price. 

(a) Each of the Optional Conversion Price and the Forced Conversion Price (each or either of which referred to in this Section as the
“Applicable Conversion Price”) shall be adjusted from time to time (without duplication) by the Company as follows: provided, however, that the adjustments provided in Sections (8)(a)(i), 8(a)(iii), 8(a)(iv), 8(a)(v), 8(a)(vi) or
8(a)(vii) shall not be made with respect to the applicable event described in such section if every Holder of Series A Preferred Stock participates, at the same time and upon the same terms as holders of our Common Stock and solely as a result of
holding shares of Series A Preferred Stock, in the relevant transaction described in such sections (without having to convert their shares of Series A Preferred Stock) as if such shares of Series A Preferred Stock had been converted into Common
Stock, in each case calculated on the applicable record date at the Optional Conversion Price. 
 (i) Stock Dividends and
Distributions. If the Company pays dividends or other distributions on the Common Stock in shares of Common Stock, then the Applicable Conversion Price in effect immediately prior to the Ex-Date for such dividend or distribution will be
multiplied by the following fraction: 
  

	
	    OS0    
	OS1

  
 Annex I-13 

 Where, 
  

					
	 OS0
	  	=	  	the number of shares of Common Stock outstanding immediately prior to Ex-Date for such dividend or distribution.
			
	 OS1
	  	=	  	the sum of the number of shares of Common Stock outstanding immediately prior to the Ex-Date for such dividend or distribution plus the total number of shares of Common Stock constituting such dividend or distribution.

 (ii) Subdivisions, Splits and Combination of the Common Stock. If the Company
subdivides, splits or combines the shares of Common Stock, then the Applicable Conversion Price in effect immediately prior to the effective date of such share subdivision, split or combination will be multiplied by the following fraction: 

 

	
	    OS0    
	OS1

 Where, 
  

					
			
	 OS0
	  	=	  	the number of shares of Common Stock outstanding immediately prior to the effective date of such share subdivision, split or combination.
			
	 OS1
	  	=	  	the number of shares of Common Stock outstanding immediately after the opening of business on the effective date of such share subdivision, split or combination.

 (iii) Issuance of Stock Purchase Rights. If the Company issues or distributes to all or
substantially all holders of the shares of Common Stock Options (other than Options issued pursuant to a dividend reinvestment plan or share purchase plan or other similar plans approved by the Board of Directors) entitling them to subscribe for or
purchase the shares of Common Stock at less than the Current Market Price on the date fixed for the determination of stockholders entitled to receive such Options, then the Applicable Conversion Price in effect immediately prior to the Ex-Date for
such issuance or distribution will be multiplied by the following fraction: 
  

	
	    OS0 + Y    
	OS0 + X

 Where, 
  

					
			
	 OS0
	  	=	  	the number of shares of Common Stock outstanding immediately prior to the Ex-Date for such distribution.
			
	 X
	  	=	  	the total number of shares of Common Stock issuable pursuant to such Options.
			
	 Y
	  	=	  	the number of shares of Common Stock equal to the aggregate price payable to exercise such Options divided by the Current Market Price on the date fixed for the determination of stockholders entitled to receive such
Options.

  
 Annex I-14 

 In the event that such Options described in this clause (iii) are not so issued, the
Applicable Conversion Price shall be readjusted, effective as of the date the Board of Directors publicly announces its decision not to issue or distribute such Options, to the Applicable Conversion Price that would then be in effect if such
issuance or distribution had not been declared. To the extent that such Options are not exercised prior to their expiration or shares of Common Stock are otherwise not delivered pursuant to such Options upon the exercise of such Options, the
Applicable Conversion Price shall be readjusted to such Applicable Conversion Price that would then be in effect had the adjustment made upon the issuance or distribution of such Options been made on the basis of the delivery of only the number of
shares of Common Stock actually delivered. In determining the aggregate offering price payable for such shares of Common Stock, there shall be taken into account any consideration received for such rights or warrants and the value of such
consideration (if other than cash, to be determined by the Board of Directors). 
 (iv) Debt or Asset Distributions.
If the Company distributes to all or substantially all holders of shares of Common Stock evidences of indebtedness, Capital Stock, securities, cash or other assets (excluding any dividend or distribution referred to in clause (i) above, any
Options referred to in clause (iii) above, any dividend or distribution paid exclusively in cash, any consideration payable in connection with a tender or exchange offer made by the Company or any of its Subsidiaries, and any dividend of
Capital Stock of or relating to a Subsidiary or other business unit in the case of certain spin-off transactions as described below), then the Applicable Conversion Price in effect immediately prior to the Ex-Date for such distribution will be
multiplied by the following fraction: 
  

	
	    SP0 - FMV    
	SP0

 Where, 
  

					
			
	 SP0
	  	=	  	the Current Market Price per share of Common Stock on such date.
			
	 FMV
	  	=	  	the fair market value of the portion of the distribution applicable to one share of Common Stock on such date as determined by the Board of Directors, provided that, if “FMV” as set forth above is equal to or
greater than “SP0” as set forth above, in lieu of the foregoing adjustment, adequate provision shall be made so that each Holder shall receive on the date on which such distribution
is made to holders of Common Stock, for each share of Series A Preferred Stock, the amount of such distribution such Holder would have received had such Holder owned a number of shares of Common Stock equal to the Applicable Conversion Price on the
Ex-Date for such distribution.

  
 Annex I-15 

 In a “spin-off”, where the Company makes a distribution to all holders of shares of
Common Stock consisting of Capital Stock of any class or series, or similar equity interests of, or relating to, a Subsidiary or other business unit, the Applicable Conversion Price will be adjusted on the fifteenth Trading Day after the effective
date of the distribution by multiplying such Applicable Conversion Price in effect immediately prior to such fifteenth Trading Day by the following fraction: 
  

	
	    MP0    
	MP0 + MP5

 Where, 
  

					
	MP0	  	=	  	the average of the Closing Prices of the Common Stock over the first ten Trading Days commencing on and including the fifth Trading Day following the effective date of such distribution.
			
	MP5	  	=	  	the average of the Closing Prices of the capital stock or equity interests representing the portion of the distribution applicable to one share of Common Stock over the first ten Trading Days commencing on and including the fifth
Trading Day following the effective date of such distribution, or, if not traded on a national or regional securities exchange or over-the-counter market, the fair market value of the capital stock or equity interests representing the portion of the
distribution applicable to one share of Common Stock on such date as determined by the Board of Directors.

 In the event that such distribution described in this clause (iv) is not so paid or made, the Applicable
Conversion Price shall be readjusted, effective as of the date the Board of Directors publicly announces its decision not to pay or make such dividend or distribution, to the Applicable Conversion Price that would then be in effect if such dividend
or distribution had not been declared. 
 (v) Cash Dividends or Distributions. If the Company makes a dividend or
distribution consisting exclusively of cash to all holders of the Common Stock, excluding (a) any cash that is paid as a dividend or distributed in a Transaction or as part of a “spin-off” referred to in clause (iv) above,
(b) any dividend or distribution in connection with a Liquidation or Deemed Liquidation, (c) any consideration payable in connection with a tender or exchange offer made by the Company or any of its Subsidiaries, and (d) a Junior
Stock Event, then in each event, the Applicable Conversion Price in effect immediately prior to the Ex-Date for such distribution will be multiplied by the following fraction: 

 

	
	    SP0 – DIV    
	SP0

  
 Annex I-16 

 Where, 
  

					
			
	SP0	  	=	  	the Closing Price per share of Common Stock on the Trading Day immediately preceding the Ex-Date.
			
	DIV	  	=	  	the amount per share of Common Stock of the cash dividend or distribution, as determined pursuant to the introduction to this paragraph (v).

 Notwithstanding the foregoing, if “DIV” as set forth above is equal to or greater than “SP0” as set forth above, in lieu of the foregoing adjustment, adequate provision shall be made so that each Holder shall have the right to receive on the date on which the relevant cash dividend
or distribution is distributed to holders of Common Stock, for each share of Series A Preferred Stock, the amount of cash such Holder would have received had such Holder owned a number of shares of Common Stock into which such shares of Series A
Preferred Stock would be converted at the Applicable Conversion Price on the Ex-Date for such dividend or distribution. 

(vi) Self Tender Offers and Exchange Offers. If the Company or any of its Subsidiaries successfully completes a tender
or exchange offer for the Common Stock where the cash and the value of any other consideration included in the payment per share of the Common Stock exceeds the Closing Price per share of the Common Stock on the Trading Day immediately succeeding
the expiration of the tender or exchange offer, then, unless every Holder of Series A Preferred Stock is offered the opportunity to participate, at the same time and upon the same terms as the holders of Common stock as if such Holder’s shares
of Series A Preferred Stock has been converted into Common Stock at the Optional Conversion Price immediately prior to such tender or exchange offer, the Applicable Conversion Price in effect at the close of business on such immediately succeeding
Trading Day will be multiplied by the following fraction: 
  

	
	        OS0 x
SP0        
	AC + (SP0 x OS1)

 Where, 
  

					
			
	SP0	  	=	  	the Closing Price per share of Common Stock on the Trading Day immediately succeeding the expiration of the tender or exchange offer.
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the expiration of the tender or exchange offer, including any shares validly tendered and not withdrawn.
			
	OS1	  	=	  	the number of shares of Common Stock outstanding immediately after the expiration of the tender or exchange offer.
			
	AC	  	=	  	the aggregate cash and fair market value of the other consideration payable in the tender or exchange offer, as determined by the Board of Directors.

 In the event that the Company, or one of its Subsidiaries, is obligated to purchase shares of Common Stock
pursuant to any such tender offer or exchange offer, but the Company, or such Subsidiary, is permanently prevented by applicable law from effecting any such purchases, or all such purchases are rescinded, then the Applicable Conversion Price shall
be readjusted to be such Applicable Conversion Price that would then be in effect if such tender offer or exchange offer had not been made. 

  
 Annex I-17 

 (vii) Rights Plans. To the extent that the Company has a rights plan in
effect with respect to the Common Stock upon conversion of any shares of the Series A Preferred Stock, unless Holders of Series A Preferred Stock shall have received the rights under such rights plan as if the shares of Series A Preferred Stock had
been converted into Common Stock at the Optional Conversion Price in effect immediately before the issuance of such rights, Holders will receive, in addition to the shares of Common Stock, the rights under the rights plan as such Holders would
receive if the shares of Series A Preferred Stock had been converted into Common Stock at the Optional Conversion Price, unless, prior to the conversion date, the rights have separated from the shares of Common Stock, in which case the Applicable
Conversion Price will be adjusted at the time of separation as if the Company had made a distribution to all holders of the Common Stock as described in clause (iv) above, subject to readjustment in the event of the expiration, termination or
redemption of such rights. 
 (viii) Issuances Below the Conversion Price. If, at any time before the Mandatory
Conversion Time, the Company issues, or agrees to issue or sell, any Common Stock or Convertible Securities for consideration per share less than the Optional Conversion Price then in effect, then the Applicable Conversion Price in effect
immediately prior to each such issuance will be reduced to the price determined by multiplying the Applicable Conversion Price in effect immediately prior to such issuance by the following fraction: 

 

	
	     OS0 + (AC/SP)    

	OS1

 Where, 
  

					
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to such issuance.
			
	AC	  	=	  	the aggregate consideration paid or payable for such shares of Common Stock or Convertible Securities.
			
	SP	  	=	  	the Optional Conversion Price.
			
	OS1	  	=	  	the sum of the number of shares of Common Stock outstanding immediately after such issuance.

 This adjustment shall become effective immediately after such issuance. 

(b) (i) All adjustments to the Applicable Conversion Price shall be calculated to the nearest 1/10 of a cent. No adjustment in
the Applicable Conversion Price shall be required if such adjustment would be less than $0.01; provided that any adjustments which by reason of this subparagraph are not required to be made shall be carried forward and taken into account in
any subsequent adjustment; provided further that on any Conversion Date adjustments to the Applicable Conversion Price will be made with respect to any such adjustment carried forward and which has not been taken into account before such
date. 

  
 Annex I-18 

 (ii) The Applicable Conversion Price shall not be adjusted: 

(1) upon the issuance of any shares of Common Stock, Options or Convertible Securities pursuant to any present or future plan
providing for the reinvestment of dividends or interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common Stock under any such plan, provided such plan was approved by the Board of
Directors; 
 (2) upon the issuance of any shares of Common Stock, Options or Convertible Securities pursuant to any present
or future employee, director or consultant benefit, agreement, plan or program of, or assumed by, the Company or any of its Subsidiaries, provided such benefit, agreement, plan or program was approved by the Board of Directors; 

(3) upon the issuance of any shares of Common Stock, Options or Convertible Securities pursuant to any Option or Convertible
Security not materially modified after the issuance thereof; 
 (4) upon the issuance of securities pursuant to any merger,
joint venture, partnership, share exchange, business combination or similar transaction or any other direct or indirect acquisition by the Company, whereby the Company’s securities comprise, in whole or in part, the consideration paid by the
Company in such transaction, provided such transaction was approved by the Board of Directors; 
 (5) for a change in the par
value or no par value of Common Stock; 
 (6) for the payment of the Dividend Equivalent Amount pursuant to
Section 3(a), or for shares of Common Stock, Options or Convertible Securities issued in connection with a dividend, stock split, split-up or other distribution to the extent that such issuance is the subject of a separate adjustment pursuant
to Section 8(a)(i), (ii), (iii) or (iv); 
 (7) upon the issuance of shares of Series A Preferred Stock issued
pursuant to the terms of the Investment Agreement or Common Stock issuable upon conversion thereof; 
 (8) for any shares of
Common Stock or Options issued to banks, equipment lessors or other lenders, or to real property lessors, in each case, in connection with a debt financing (limited to secured or unsecured debt for borrowed money that is not pursuant to the issuance
of Convertible Securities), equipment leasing or real property leasing transaction, provided such transaction was approved by the Board of Directors; 

  
 Annex I-19 

 (9) for shares of Common Stock, Options or Convertible Securities issued as a
dividend or distribution on Series A Preferred Stock; 
 (10) for shares of Common Stock, Options or Convertible Securities
issued to suppliers or third party service providers who are not Affiliates of the Company, in each case, in connection with the provision of goods or services on terms and conditions approved by the Board of Directors; or 

(11) shares of Common Stock, Options or Convertible Securities issued to third parties who are not Affiliates of the Company in
connection with sponsored research, collaboration, technology license, development, OEM, marketing or other similar agreements or strategic partnerships, in each case, on terms and conditions approved by the Board of Directors of the Company. 

(c) Whenever the Applicable Conversion Price is to be adjusted in accordance with Section 8(a), the Company shall:
(i) compute the Applicable Conversion Price in accordance with the applicable clause of Section 8(a), taking into account the $0.01 threshold set forth in Section 8(b); (ii) as soon as practicable following the occurrence of an
event that requires an adjustment to the Applicable Conversion Price pursuant to Section 8(a), taking into account the $0.01 threshold set forth in Section 8(b), provide, or cause to be provided, a written notice to the Holders of the
occurrence of such event; and (iii) as soon as practicable following the determination of the revised Applicable Conversion Price in accordance with Section 8(a), provide, or cause to be provided, a written notice to the Holders setting
forth in reasonable detail the method by which the adjustment to the Applicable Conversion Price was determined and setting forth the revised Applicable Conversion Price and the number of shares of Common Stock which shall be deliverable upon
conversion of one share of Series A Preferred Stock. 
 (d) If one or more events occurs requiring an adjustment to be made
to the Applicable Conversion Price during the same time period, adjustments to the Applicable Conversion Price shall be determined by the Board of Directors to reflect the combined impact of all Conversion Price adjustment events, as set out in this
Section 8, during such period. 
 (e) In the event that at any time as a result of any adjustment made pursuant to this
Section 8 or otherwise, it will be necessary for the Company to obtain stockholder approval, then the Company shall use its reasonable best efforts to obtain such stockholder approval as promptly as practicable. 

(f) If an adjustment to the Applicable Conversion Price is to be made pursuant to more than one section or subsection of this
Section 8, adjustment shall be made in accordance with only one section or subsection to fairly protect the rights of the Holders in accordance with the essential interest and principles hereof as determined in good faith by the Board of
Directors. Anything in this Section 8 notwithstanding, no adjustment to the Applicable Conversion Price shall reduce the Applicable Conversion Price below the then par value per share of Common Stock, and any such purported adjustment shall
instead reduce the Applicable Conversion Price to such par value. 

  
 Annex I-20 

 (g) For the purposes of this Section 8, (i) the number of shares of
Common Stock at the time outstanding shall not include shares acquired by the Company, and (ii) the number of shares of Common Stock outstanding shall include Common Stock issuable upon the exercise of Options and conversion of Convertible
Securities, including Series A Preferred Stock at the Optional Conversion Price then in effect. 
 9. Recapitalization, Reclassification
and Changes in Common Stock. Subject to Section 4(b), upon the occurrence of any: 
 (a) reclassification or change
of the outstanding shares of Common Stock (other than a change in par value, or from par value to no par value, or from no par value to par value); 

(b) merger or consolidation of the Company with or into another Person (other than a Subsidiary) other than a merger or
consolidation in which the Company is the resulting or surviving Person and which does not result in any reclassification or change of outstanding Common Stock; 

(c) any statutory share exchange of the Company with another Person; or 

(d) sale or other disposition of all or substantially all of the property and assets of the Company (on a consolidated basis)
to any other Person (any of the foregoing events in clauses (a) through (d), a “Transaction”); then, without limiting the rights of the Holders in Section 4 herein, the Series A Preferred Stock shall be convertible after
the Transaction, in lieu of the Common Stock into which it was convertible prior to such event, into the kind and amount of shares of stock or other securities or other property or assets (including cash) that the Holders would have been entitled to
receive upon such Transaction had such Series A Preferred Stock been converted into Common Stock at the Optional Conversion Price immediately prior to such Transaction. 

The provisions of this Section 9 shall apply to successive Transactions. Notwithstanding the foregoing, this Section 9 shall not apply to the extent
that, with respect to an occurrence described in clause (a) above, such occurrence is the subject of a separate adjustment pursuant to Section 8(a)(i), (ii), (iii) or (iv). In the event that holders of the Common Stock shall have the
opportunity to elect the form of consideration to be received in a Transaction, then the Company shall make adequate provision whereby each Holder shall have a reasonable opportunity to determine the form of consideration into which all of such
Holder’s shares of Series A Preferred Stock, shall be convertible from and after the effective date of such Transaction. Such determination shall be (i) subject to any limitations to which all of the holders of Common Stock are subject,
including, but not limited to, pro rata reductions applicable to any portion of the consideration payable in such Transaction and (ii) conducted in such a manner as to be completed by the date that is the earlier of (a) the deadline for
elections to be made by holders of Common Stock and (b) five (5) Trading Days prior to the anticipated effective date of such Transaction. The Company will not effect (or enter into any agreement providing for) any Transaction unless prior
to the consummation thereof the successor Person (if other than the Company) resulting from such Transaction shall assume by written instrument mailed or delivered to the Holders at the last address of each such Holder appearing on the Register, the
obligation pursuant to this Section 9. At least twenty (20) days’ prior written notice of the date on which the Transaction will be consummated shall be given to the Holders. 

  
 Annex I-21 

 10. Special Redemption. 

(a) Strategic Investment Committee Event. The Company shall form the Strategic Investment Committee as provided in the
Investment Agreement, which shall (i) be the exclusive gateway for the Specified Matters to be evaluated and recommended to the Board of Directors and (ii) have special authority to make recommendations with respect to the investment of
cash balances of the Company in U.S. Treasury bills and other high-grade publicly traded securities in conformity with cash investment policies to be approved by the Company, in each case, so long as the Investor Group holds at least 50% of the sum
of (x) the shares of Common Stock purchased by the Investor Group pursuant to the Investment Agreement and (y) the number of shares of Common Stock into which the total number of shares of Series A Preferred Stock purchased by the Investor
Group pursuant to the Investment Agreement is convertible using the Optional Conversion Price. The Strategic Investment Committee shall have at least ten (10) business days to consider and make a recommendation with respect to a Specified
Matter presented to it by the Chief Executive Officer of the Company; provided, that if the Chief Executive Officer of the Company advises the other members of the Strategic Investment Committee that (i) the opportunity represented by the
Specified Matter shall require action of the Company within three (3) business days, (ii) if the Strategic Investment Committee shall not act within such period of time the advantages to the Company of such Specified Matter shall be
jeopardized, or (iii) the failure to approve such Specified Matter shall have an adverse effect on the Company, the Strategic Investment Committee shall have a reasonable period of time but not less than two (2) business days to consider
such Specified Matter. As a general rule, in case of rejection by the Strategic Investment Committee, Specified Matters are not submitted to the Board of Directors. However, members of the Strategic Investment Committee who are also members of the
Board of Directors have the right to submit rejected Specified Matters to the Board of Directors. If the Board of Directors (A) revokes or restricts the authority of the Strategic Investment Committee, or (B) fails to appoint the Purchaser
Designee (if a Purchaser Designee is then serving on the Board of Directors) to the Strategic Investment Committee (any such event, a “SIC Event”), the Holders shall have the right to require the immediate redemption of all or part,
of their Series A Preferred Stock at a price equal to the Liquidation Preference per share set forth in Section 4(a)(i), as set forth in this Section 10. 

(b) General. Unless prohibited by Delaware law governing distributions to stockholders, shares of Series A Preferred
Stock shall be redeemed by the Company not more than ninety (90) days after receipt by the Company, from the Required Holders of written notice specifying in reasonable detail the SIC Event that such Holders believe occurred and the number of
shares of Series A Preferred Stock to be redeemed (the “Redemption Request”); provided, that such redemption shall not be required if the Company cures the SIC Event specified in the Redemption Request within thirty (30) days after
its receipt of the Redemption Request. Upon the expiration of such ninety-day period, unless the Company shall have cured such SIC Event as aforesaid, the Company shall apply all of its assets legally available for the redemption of its Series A
Preferred Stock to any such redemption. 

  
 Annex I-22 

 (c) Redemption Notice. The Company shall send written notice of the
redemption (the “Redemption Notice”) to each Holder of Series A Preferred Stock not less than forty (40) days prior to the date fixed by the Company for such redemption (such date is referred to as the “Redemption
Date”). Each Redemption Notice shall state: 
  

	 	(i)	the number of shares of Series A Preferred Stock held by the Holder that the Company shall redeem on the Redemption Date specified in the Redemption Notice; 

 

	 	(ii)	the Redemption Date and the Redemption Price; and 

  

	 	(iii)	that the Holder is to surrender to the Company, in the manner and at the place designated, his, her or its certificate or certificates representing the shares of Series A Preferred Stock to be redeemed.

 If the Company receives, on or prior to the 20th day after the date of delivery of the Redemption Notice to a Holder of
Series A Preferred Stock, written notice from such Holder that such Holder elects to be excluded from the redemption provided in this Section 10, then the shares of Series A Preferred Stock registered on the books of the Company in the name of
such Holder at the time of the Company’s receipt of such notice shall not be redeemed or redeemable pursuant to this Section 10 with respect to the SIC Event specified in the Redemption Request, whether on such Redemption Date or
thereafter; provided, that such Holder shall be entitled to have such Holder’s Series A Preferred Stock redeemed in accordance with this Section 10 in connection with a subsequent SIC Event, unless cured as aforesaid. If on the Redemption
Date Delaware law governing distributions to stockholders prevents the Company from redeeming all shares of Series A Preferred Stock to be redeemed, the Company shall ratably redeem the maximum number of shares that it may redeem consistent with
such law, and shall redeem the remaining shares as soon as it may lawfully do so under such law. 
 (d) Surrender of
Certificates; Payment. On or before the Redemption Date, each holder of shares of Series A Preferred Stock to be redeemed on the Redemption Date, unless such Holder has exercised his, her or its right to convert such shares as provided in
Section 7, shall surrender the certificate or certificates representing such shares (or, if such registered holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably
acceptable to the Corporation to indemnify the Company against any claim that may be made against the Company on account of the alleged loss, theft or destruction of such certificate) to the Company, in the manner and at the place designated in the
Redemption Notice, and thereupon the Redemption Price for such shares shall be payable to the order of the person whose name appears on such certificate or certificates as the owner thereof. In the event less than all of the shares of Series A
Preferred Stock represented by a certificate are redeemed, a new certificate representing the unredeemed shares of Series A Preferred Stock shall promptly be issued to such Holder. 

  
 Annex I-23 

 (e) Rights Subsequent to Redemption. If the Redemption Notice shall have
been duly given, and if on the Redemption Date the Redemption Price payable upon redemption of the shares of Series A Preferred Stock to be redeemed on such Redemption Date is paid or tendered for payment or deposited with an independent payment
agent so as to be available therefor in a timely manner, then notwithstanding that the certificates evidencing any of the shares of Series A Preferred Stock so called for redemption shall not have been surrendered, dividends with respect to such
shares of Series A Preferred Stock shall cease to accrue after such Redemption Date and all rights with respect to such shares shall forthwith after the Redemption Date terminate, except only the right of the Holders to receive the Redemption Price
without interest upon surrender of their certificate or certificates therefor. 
 11. Other Provisions. 

(a) Shares of Series A Preferred Stock redeemed, issued and reacquired shall be prohibited from being reissued as such and will
be retired and canceled promptly after reacquisition thereof and, upon compliance with the applicable requirements of Delaware law, will have the status of authorized but unissued shares of preferred stock of the Company undesignated as to series
and may with any and all other authorized but unissued shares of preferred stock of the Company be designated or redesignated and issued or reissued, as the case may be, as part of any series of preferred stock of the Company, except that any
issuance or reissuance of shares of Series A Preferred Stock must be in compliance with this Certificate. 
 (b) The shares
of Series A Preferred Stock shall be issuable only in whole shares. 
 (c) All notices referred to herein shall be in
writing, and, unless otherwise specified herein, all notices hereunder shall be deemed to have been given upon the earlier of receipt thereof or three Business Days after the date of mailing thereof if sent by registered or certified mail (unless
first-class mail shall be specifically permitted for such notice under the terms of this Certificate) with postage prepaid, addressed: (i) if to the Company, to its office at 220 South Orange Avenue, Livingston, NJ 07039, Attention: Chief
Executive Officer and Chief Financial Officer, or (ii) if to any Holder, to such Holder at the address of such Holder as listed in the Register, or (iii) to such other address as the Company or any such Holder, as the case may be, shall
have designated by notice similarly given. Any notice that was mailed in the manner herein provided shall be conclusively presumed to have been duly given whether or not the Holder receives the notice. 

(d) If at any time the Company is required to make any payment to a Holder pursuant to this Certificate, the Company does not
have sufficient funds legally available to make such payment, the Company shall make as much of such required payment as possible, ratably to each Holder in proportion to the number of shares of Series A Preferred Stock held by such Holder, and
shall thereafter from time to time, as soon as it shall have funds available therefor, make payment of as much of the remaining amount of such required payment as it legally may until it has made such payment in its entirety. For the avoidance of
doubt, such partial payments shall not reduce or waive the rights of the Holders hereunder. 

  
 Annex I-24 

 (e) The words “hereby”, “herein”, “hereof”,
“hereunder” and words of similar import refer to this Certificate as a whole and not merely to the specific section, paragraph or clause in which such word appears. The words “include”, “includes” and
“including” shall be deemed to be followed by the phrase “without limitation”. The definitions given for terms in Section 2 and elsewhere in this Certificate shall apply equally to both the singular and plural forms of the
terms defined. Whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. 

(f) Upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of any
certificate evidencing any Series A Preferred Stock owned by a Holder and (in the case of loss, theft or destruction) of an unsecured indemnity satisfactory to it, and upon reimbursement to the Company of all reasonable expenses incidental thereto,
and upon surrender and cancellation of such certificate, if mutilated, the Company will make and deliver in lieu of such certificate a new certificate of like tenor and for the number of securities evidenced by such certificate which remains
outstanding. 
 (g) Any of the terms of this Certificate may be amended or rights of the Holders set forth herein (including,
without limitation, any rights to notices, adjustments or otherwise) may be waived by (i) any Holder with respect to such Holder, provided that such waiver is in writing and executed by such Holder, and (ii) the written consent of the
Required Holders with respect to all Holders, and such amendment or waiver shall be binding on all Holders; provided, however, prior to the effective date of an amendment to this Certificate approved by the Required Holders which
amendment amends the Applicable Terms, the Company shall give each Holder five (5) Business Days’ notice to permit such Holder to convert such Holder’s shares of Series A Preferred Stock pursuant to Section 7(a) herein, subject
to any limitations in this Certificate on the number of shares of Series A Preferred Stock that may be converted. Notwithstanding the foregoing, the Required Holders shall not amend the foregoing proviso without the consent of each Holder affected
thereby. 
 12. Tax Withholdings and Certain Other Matters. 

(a) The Company may withhold from or pay on behalf of any Holder the amount of federal, state, local or foreign taxes that the
Company shall reasonably believe the Company is required to withhold or pay with respect to such Holder’s interest in the Company and/or any amount payable, distributable or allocable to such Holder pursuant to this Certificate, including,
without limitation, any taxes required to be paid by the Company pursuant to Code Sections 1441, 1442 or 1445 and any taxes imposed by any state or other taxing jurisdiction on the Company as an entity. Without limiting the foregoing, the Company
shall be entitled to withhold (and remit to the appropriate governmental authority), from amounts otherwise distributable or payable to a Holder, any taxes that such Holder notifies the Company in writing should be withheld, which notice shall be
given by any Holder who becomes aware of any withholding obligation to which it is subject and shall specifically set forth, inter alia, the rate at which tax should be withheld and the name and address to which any amounts withheld should be
remitted. 

  
 Annex I-25 

 (b) Each Holder agrees to cooperate fully with all efforts of the Company to
comply with its tax withholding and information reporting obligations and agrees to provide the Company with such information as the Company may reasonably request from time to time in connection with such obligations. 

(c) Except as otherwise provided in this Certificate, if the Company is obligated to pay any amount to a governmental authority
(or otherwise makes a payment to a governmental authority) that is specifically attributable to a Holder or a Holder’s status as the holder of Capital Stock of the Company or a Subsidiary (including federal, state or foreign withholding taxes,
state personal property taxes, and state unincorporated business taxes), then such person shall indemnify the Company in full for the entire amount paid and/or required to be paid (including interest, penalties and related expenses). The Company may
offset distributions and other payments to which a person is entitled under this Certificate or otherwise against such person’s obligation to indemnify the Company under this Section 12. A Holder’s obligation to indemnify the Company
under this Section 12 shall survive the termination, dissolution, liquidation and winding up of the Company, and, for purposes of this Section 12, the Company shall be treated as continuing in existence. The Company may pursue and enforce
all rights and remedies it may have against each Holder under this Section 12, including instituting a lawsuit to collect such indemnification payment with interest calculated at the applicable federal rate determined from time to time under
Code Section 7872(f)(2) (or any successor provision thereto) (but not in excess of the highest rate per annum permitted by law). 

  
 Annex I-26

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