Document:

<PAGE>

                                                                    EXHIBIT 4.3

Schedule identifying material details of option agreements issued by the Company
to Princeton Corporate Plaza, LLC substantially identical to the Option
Agreement filed as Exhibit 4.2

<TABLE>
<CAPTION>

     DATE           OPTION              NUMBER OF
    ISSUED            NO.                SHARES                   EXERCISE PRICE          EXERCISE PERIOD
    ------          ------               ------               ----------------------    ------------------
<S>                  <C>                  <C>                 <C>                      <C>
   5/06/03            LL3                  6,667              Exercise price:  $1.50    5/31/05 to 5/30/10

   5/06/03            LL4                  6,667              Exercise price:  $1.50    5/31/06 to 5/30/11
</TABLE><PAGE>

                                                                   EXHIBIT 10.1

                              CONSULTING AGREEMENT

         THIS CONSULTING AGREEMENT (the "Agreement") dated this May 15, 2003,
between CHIRAL QUEST, INC., a Minnesota corporation (together with its
successors and assigns referred to herein as the "Company"), with principal
Consultant offices located at 1981 Pine Hall Drive, State College, PA 16801 787
Seventh Avenue, New York, NY 10019 and XUMU ZHANG, PH.D., residing at 276
Camelot Lane, State College, PA 16803 (the "Consultant").

                               W I T N E S S E T H

         WHEREAS, the Company desires to continue to retain Consultant on an
exclusive consultancy basis to engage in such activities and to render such
services under the terms and conditions hereof and has authorized and approved
the execution of this Agreement; and

         WHEREAS, Consultant desires to continue to be retained by the Company
on an exclusive consultancy basis under the terms and conditions hereinafter
provided;

         NOW, THEREFORE, in consideration of the mutual covenants and
undertakings herein contained, the parties agree as follows:

         1.   CONSULTANCY, DUTIES AND ACCEPTANCE.

              1.1 SERVICES. You will be retained by the Company to be its
Chief Technology Officer. You will report to the Chief Executive Officer of the
Company (the "Board") and shall perform such duties as are consistent with your
position as Chief Technology Officer (the "Services") including, but not limited
to, direction of employees and/or research projects under contract between the
Company and Consultant's laboratory within the Pennsylvania State University,
direction of technical-development activities by the Company's research
personnel, direction of research and manufacturing activities in support of the
Company's technologies and commercial activities and business and that of its
third party manufacturers and customers and prospective customers. The
Consultant will also direct all of the Company's commercial and scientific
development of its technology, including commercial scale up and manufacturing
processes for it ligands owned or controlled, via license or otherwise, by the
Company. You agree to perform such duties faithfully and, subject to your
obligations to PSU (more fully described in Paragraph 5) to devote all your
working time, attention and energies to the business of the Company. Consultant
further agrees not to engage in any other business activity that is in conflict
with his duties and obligations to the Company. Consultant will not provide
consulting services to any person, entity, company, or party without the express
written consent of the Company and Consultant further agrees that the Company
shall have the right to prohibit the Consultant from entering into any
consulting agreement or other agreement that the Company, in its sole
discretion, deems might have a material adverse effect on the Company's
business.  Additionally, during the term of this Agreement, the Board of
Directors shall use its best efforts to nominate you for election as a director
of the Company at each annual meeting of the Company.

<PAGE>

         1.2  ACCEPTANCE.  Consultant hereby accepts such engagement and
agrees to render the Services.

         2.   TERM OF CONSULTANCY.

              2.1 TERM. The Consultant's obligations under this Agreement
(the "Term") shall commence as of the Effective Date (as hereinafter defined)
and shall continue for a term of four (4) years, unless sooner terminated
pursuant to Section 7 of this Agreement. Notwithstanding anything to the
contrary contained herein, the provisions of this Agreement governing Protection
of Confidential Information and Non-Compete shall continue in effect as
specified in Sections 4 and 8 hereof and survive the expiration or termination
of this Agreement. Prior to the expiration of the Term, but no less than ninety
(90) days prior to the expiration of the Term, the Term may be extended for
additional one (1) year periods upon mutual written consent of the Consultant
and the Board.

              2.2 EFFECTIVE DATE.  The effective date of this Agreement
is the date as first written above.

         3.   COMPENSATION.

              3.1 FEES. The Company shall pay Consultant fees (the "Base
Salary") equal One Hundred Twenty Thousand Dollars ($120,000.00) per year,
payable in bi-monthly installments.

              3.2 EXPENSE REIMBURSEMENT. All travel and other expenses
reasonably incurred by Consultant incidental to the rendering of services to the
Company hereunder shall be paid by the Company or reimbursed to Consultant upon
receipt and approval of expense reports on Company forms supported by
appropriate documentation. From time to time, Consultant shall submit, and
obtain approval for, proposed expense budgets. All unbudgeted expenses in excess
of $2,000.00 (individually, or collectively if in connection with a single,
related subject or project within a given month) shall require advance approval.
The Company will reimburse Consultant, or pay in advance, for reasonable
itemized travel and other expenses incurred incidental to rendering services to
the Company prior to the Effective Date.

              3.4 OPTIONS. Consultant shall be entitled to receive options
to purchase a 650,052 shares of common stock of the Company, par value $.01 per
share (the "Common Stock") (determined by multiplying the issued and outstanding
Common Stock of the Company as of the Effective Date by 5%) at an exercise price
per share equal to $1.49 (the "Options") (subject to adjustment for splits
and/or other capital restructuring). The Options shall vest as follows:

              (a) 162,513 Options will vest on the date that is one year
                  from the Effective Date;
              (b) 162,513 Options will vest on the date that is two years
                  from the Effective Date;
              (c) 162,513 Options will vest on the date that is three years
                  from the Effective Date; and

                                       2

<PAGE>

              (d) 162,513 Options will vest on the date that is four years
                  from the Effective Date.

No Options will vest until the first anniversary of the Effective Date. With the
exception of the foregoing terms described in this Section 3.4, all terms of the
Options will be consistent with Company's employee stock option plan to be
implemented by the Company following the Effective Date. In the event Consultant
is terminated without Cause, or terminates this Agreement for a Good Reason, all
Options shall immediately vest and shall expire unless exercised prior to the
date that is 90 days from the date of termination. If the Consultant is
terminated for Cause, or terminates this Agreement without Good Reason, all
unvested Options shall not vest and shall immediately expire and become void.

              3.5 BONUSES.  The Board of Directors of the Company may,
at its sole discretion, issue bonuses to the Consultant as, when and in amounts
to be determined by the Board.

         4.   CONFIDENTIAL INFORMATION AND INVENTIONS.

              4.1 The Consultant recognizes and acknowledges that in the
course of his duties he is likely to receive confidential or proprietary
information owned by the Company, its affiliates or third parties with whom the
Company or any such affiliates has an obligation of confidentiality.
Accordingly, during and after the Term, the Consultant agrees to keep
confidential and not disclose, publish, or make accessible to any other person
or use for any other purpose other than in connection with the fulfillment of
his duties under this Agreement, any Confidential and Proprietary Information
(as defined below) owned by, or received by or on behalf of, the Company or any
of its affiliates. "Confidential and Proprietary Information" shall include, but
shall not be limited to, confidential or proprietary scientific or technical
information, data, formulas and related concepts, business plans (both current
and under development), client lists, promotion and marketing programs, trade
secrets, or any other confidential or proprietary business information relating
to development programs, costs, revenues, marketing, chemical diagrams, the
application of catalysts to chiral molecules and manufacturing and development
thereof, manufacturing and developments plans and processes, patent applications
and continuations or continuations in part, investments, sales activities,
promotions, credit and financial data, manufacturing processes, financing
methods, plans or the business and affairs of the Company or of any affiliate or
client of the Company. The Consultant expressly acknowledges the trade secret
status of the Confidential and Proprietary Information and that the Confidential
and Proprietary Information constitutes a protectable business interest of the
Company. The Consultant agrees: (i) not to use any such Confidential and
Proprietary Information for himself or others; and (ii) not to take any Company
material or reproductions (including but not limited to writings,
correspondence, notes, drafts, records, invoices, technical and business
policies, computer programs or disks) thereof from the Company's offices at any
time during his employment by the Company, except as required in the execution
of the Consultant's duties to the Company. The Consultant agrees to return
immediately all Company material and reproductions (including but not limited,
to writings, correspondence, notes, drafts, records, invoices, technical and
business policies, computer programs or disks) thereof in his possession to the
Company upon request and in any event immediately upon termination of this
Agreement.

              4.2 Except with prior written authorization by the Company,
the Consultant agrees not to disclose or publish any of the Confidential and
Proprietary Information, or any confidential, scientific, technical or business
information of any other party to whom the Company or any of its affiliates owes
an obligation of confidence, at any time during or after his employment with the
Company.
                                       3
<PAGE>

              4.3 Subject to Paragraph 5, the Consultant agrees that all
inventions, discoveries, improvements and patentable or copyrightable works,
including but not limited to, chiral chemistry, the application of catalysts to
chiral molecules, ligand families, and pharmaceutical and chemical manufacturing
processes ("Inventions") initiated, conceived or made by him, either alone or in
conjunction with others, during the Term shall be the sole property of the
Company to the maximum extent permitted by applicable law and, to the extent
permitted by law, shall be "works made for hire" as that term is defined in the
United States Copyright Act (17 U.S.C.A., Section 101). The Company shall be the
sole owner of all patents, copyrights, trade secret rights, and other
intellectual property or other rights in connection therewith. The Consultant
hereby assigns to the Company all right, title and interest he may have or
acquire in all such Inventions. The Consultant further agrees to assist the
Company in every proper way (but at the Company's expense) to obtain and from
time to time enforce patents, copyrights or other rights on such Inventions in
any and all countries, and to that end the Consultant will execute all documents
necessary:

                  (a) to apply for, obtain and vest in the name of the
         Company alone (unless the Company otherwise directs) letters patent,
         copyrights or other analogous protection in any country throughout the
         world and when so obtained or vested to renew and restore the same; and

                  (b) to defend any opposition proceedings in respect of such
         applications and any opposition proceedings or petitions or
         applications for revocation of such letters patent, copyright or other
         analogous protection.

              4.4 The Consultant acknowledges that while performing the
services under this Agreement the Consultant may locate, identify and/or
evaluate patented or patentable inventions having commercial potential in the
fields of pharmacy, pharmaceutical, biotechnology, chemistry, manufacturing,
healthcare, technology and other fields which may be of potential interest to
the Company or one of its affiliates (the "Third Party Inventions"). The
Consultant understands, acknowledges and agrees that all rights to, interests in
or opportunities regarding, all Third-Party Inventions identified by the
Company, any of its affiliates or either of the foregoing persons' officers,
directors, employees (including the Consultant), agents or consultants during
the Employment Term shall be and remain the sole and exclusive property of the
Company or such affiliate and the Consultant shall have no rights whatsoever to
such Third-Party Inventions and will not pursue for himself or for others any
transaction relating to the Third-Party Inventions which is not on behalf of the
Company.

              4.5 CONSULTANT DISCLOSURE. Consultant agrees that he will
promptly disclose to the Company, or any persons designated by the Company, all
improvements, Inventions made or conceived or reduced to practice or learned by
him, either alone or jointly with others, during the Term.

              4.6 The Company acknowledges that the Consultant has an
obligation to publish knowledge in connection with his duties as a research
scientist employed by PSU. The consultant agrees to disclose any such proposed
publication relating to technologies licensed or otherwise owned by the Company
at least 60 days prior to his submission for publication or lecture. The Company
will reasonably determine whether such publication or lecture may potentially
have a material adverse effect on the Company. The Consultant will agree to
amend or alter such publication or lecture in accordance with the Company's
direction so that the Company may protect its interests, or at the Company's
request, delay such publication or lecture for a period of time necessary for
the Company to file patent application, continuations in parts, or other
documents that it may reasonably deem necessary to protect its interests.

                                       4
<PAGE>
         5.   PENNSYLVANIA STATE UNIVERSITY OBLIGATIONS.

              5.1 The Company agrees and understands that he Consultant is
an employee of the Pennsylvania State University ("PSU") and that the
Consultant's primary responsibility is to PSU. In connection with such
employment, the Consultant has entered into certain agreements with PSU relating
to the ownership of intellectual property rights, conflicts of interest, and
other matters, and is subject to certain policy statement of PSU (collectively
the "Institutional Agreements", attached hereto as Exhibit 5). If any provision
of this Agreement is hereinafter determined to be in conflict with any
Institutional Agreement, the Institutional Agreement will govern to the extent
of such conflict, and the conflicting provisions of this Agreement will not
apply. The Consultant is not aware of such conflict, and is further obligated to
notify the Company of the existence of any Institutional Agreement executed by
the Consultant or instituted by PSU subsequent to the date of this Agreement and
immediately provide a copy of such Institutional Agreement to the Company. The
Consultant represents and warrants that Exhibit 5 is complete and accurate.

              5.2 The consulting work performed hereunder will not be
conducted on time that is required to be devoted to PSU under the Institutional
Agreements. Except with the written consent of PSU, the Consultant shall not use
the funding, resources or facilities of PSU to perform consulting work hereunder
and shall not perform the consulting services hereunder in any manner that would
give PSU or any other third party rights to the product of such work.

              5.3 The Consultant acknowledges and agrees that any Invention
created by him during the Term that is not owned by PSU pursuant to the
Institutional Agreements will be owned exclusively by the Company under this
Agreement.

         6.   CONSULTANT REPRESENTATIONS & WARRANTIES

              The Consultant hereby represents and warrants to the Company as
follows:

              6.1 Neither the execution or delivery of this Agreement nor
the performance by the Consultant of his duties and other obligations hereunder
violate or will violate any statute, law, determination or award, or conflict
with or constitute a default or breach of any covenant or obligation under
(whether immediately, upon the giving of notice or lapse of time or both) any
prior employment agreement, contract, PSU policy or guideline, or other
instrument to which the Consultant is a party or by which he is bound. The
Consultant represents that there is no conflict of interest between his current
consulting duties with any third parties and his duties to the Company under
this agreement. A listing of all relationships to which the Consultant or his
laboratory at PSU is party is attached hereto as Exhibit 6.1 and Consultant
further represents and warrants that he is not a party to any agreement, written
or verbal, other than those listed in Exhibit 6.1, and that the performance of
his duties in connection with this Agreement does not conflict with the
agreements listed in Exhibit 6.1.

                                       5
<PAGE>

              6.2 The Consultant has the full right, power and legal
capacity to enter and deliver this Agreement and to perform his duties and other
obligations hereunder. This Agreement constitutes the legal, valid and binding
obligation of the Consultant enforceable against him in accordance with its
terms. No approvals or consents of any persons or entities are required for the
Consultant to execute and deliver this Agreement or perform his duties and other
obligations hereunder, with the exception of those approvals or consents
required pursuant to Consultant's employment with PSU, and Consultant hereby
represents and warrants that he has received all such necessary consents and
approvals.

              6.3 The Consultant understands that he is not an employee of
the Company, but an independent contractor. Nevertheless, the Consultant further
understands that he is a senior officer and director of the Company, and
accordingly has such responsibilities and liabilities commensurate with such
positions.

         7.   TERMINATION.

              7.1 DEATH. If Consultant dies during the Term of this
Agreement, Consultant's employment hereunder shall terminate upon his death and
all obligations of the Company hereunder shall terminate on such date, except as
provided in 7.6(a).

              7.2 DISABILITY. If Consultant shall be unable to perform a
significant part of his duties and responsibilities in connection with the
conduct of the business and affairs of the Company and such inability lasts for
a period of at least 180 consecutive days by reason of Consultant's physical or
mental disability, whether by reason of injury, illness or similar cause,
Consultant shall be deemed disabled, and the Company any time thereafter may
terminate the Agreement by reason of the disability. During such 180 day period,
the Base Salary and other benefits payable to Consultant hereunder shall not be
suspended or diminished. Upon delivery to Consultant of notice to terminate, all
obligations of the Company hereunder shall terminate, except as provided in
7.6(a).

              7.3 TERMINATION FOR CAUSE. The Company may at any time during
the Term, with fifteen (15) days prior written notice, terminate this Agreement
and discharge Consultant for Cause, whereupon the Company's obligation to pay
compensation or other amounts payable hereunder to or for the benefit of
Consultant shall terminate on the date of such discharge. As used herein the
term "Cause" shall be deemed to mean and include: (i) a material breach by
Consultant of this Agreement including without limitation a breach by Consultant
of the obligations set forth in Section 4 or Section 8 hereof; (ii) excessive
absenteeism, alcoholism or drug abuse; (iii) substantial neglect or inattention
by Consultant of or to his duties hereunder; (iv) willful violation of specific
and lawful written or oral direction from the Board of Directors of the Company;
or (v) fraud, criminal conduct or embezzlement. The following shall be deemed a
material breach for the purposes of Subsection (i) hereof: (a) the Consultant's
conviction for, or a plea of nolo contendere to, a felony or a crime involving
moral turpitude; (b) willful misconduct as an employee of the Company, which is
detrimental to the business of the Company; or (c) willful or reckless disregard
of his responsibilities under this Agreement. The obligations of the Consultant
under Section 4 and Section 8 shall continue notwithstanding termination of the
Consultant's employment pursuant to this Section 7.3.

              7.4 GOOD REASON. This Agreement may be terminated by the
Consultant for Good Reason. For purposes of this Agreement, "GOOD REASON" shall
mean any of the following: (i) the assignment to the Consultant of duties
inconsistent with the Consultant's position, duties, responsibilities, titles or
offices as described herein; (ii) any material reduction by the Corporation of
the Consultant's duties and responsibilities; or (iii) any reduction by the
Corporation of the Consultant's compensation or benefits payable hereunder (it
being understood that a reduction of benefits applicable to all employees of the
Corporation, including the Consultant, shall not be deemed a reduction of the
Consultant's

                                       6
<PAGE>

compensation package for purposes of this definition).

              7.5 CHANGE OF CONTROL. This Agreement may be terminated by the
Board of Directors of the Company (or its successor) in its sole discretion upon
the occurrence of a Change of Control. For purposes of this Agreement, "Change
of Control" means (i) the acquisition, directly or indirectly, following the
date hereof by any person (as such term is defined in Section 13(d) and 14(d)(2)
of the Securities Exchange Act of 1934, as amended), in one transaction or a
series of related transactions, of securities of the Company representing in
excess of fifty percent (50%) or more of the combined voting power of the
Company's then outstanding securities if such person or his or its affiliate(s)
do not own in excess of 50% of such voting power on the date of this Agreement,
or (ii) the future disposition by the Company (whether direct or indirect, by
sale of assets or stock, merger, consolidation or otherwise) of all or
substantially all of its business and/or assets in one transaction or series of
related transactions (other than a merger effected exclusively for the purpose
of changing the domicile of the Company).

              7.6 COMPENSATION UPON TERMINATION.

                  (a) If this Agreement is terminated by the Company as
         a result of his death or Disability, the Company shall pay to the
         Consultant or to the Consultant's estate, as applicable, (x) his Base
         Salary and any accrued and any unpaid Bonus and expense reimbursement
         amounts through the date of his Death or Disability. All Stock Options
         that are scheduled to vest by the end of the calendar year in which
         such termination occurs shall be accelerated and deemed to have vested
         as of the termination date. All Stock Options that have not vested (or
         been deemed pursuant to the immediately preceding sentence to have
         vested) as of the date of termination shall be deemed to have expired
         as of such date.

                  (b) If this Agreement is terminated by the Board of
         Directors of the Company for Cause, or by Consultant without Good
         Reason, then the Company shall pay to the Consultant his Base Salary
         through the date of his termination and the Consultant shall have no
         further entitlement to any other compensation or benefits from the
         Company. All Stock Options that have not vested (or been deemed
         pursuant to the immediately preceding sentence to have vested) as of
         the date of termination shall be deemed to have expired as of such
         date.

                  (c) If this Agreement is terminated as a result of a
         Change of Control resulting in the Company or its stockholders
         receiving at least $50,000,000 in value, then, in the event that the
         Company elects to terminate the Consultant pursuant to Section 7.5, the
         Company shall (i) pay the Consultant the Base Salary for up to one (1)
         year and (ii) cause any unvested options then owned by the Consultant
         to vest immediately and remain exercisable for 180 days. If the
         stockholders receive less than $50,000,000 in value pursuant to such
         transaction, the Company shall have no further obligations to the
         Consultant and all of Consultant's unvested options shall expire.

                  (d) If this Agreement is terminated by the Company
         other than as a result of the Consultant's death or Disability and
         other than for reasons specified in Sections 7.3-7.5, then the Company
         shall continue to pay to the Consultant his fee for a period of one (1)
         year following such termination, and (ii) pay the Consultant any
         expense reimbursement amounts owed through the date of termination. All
         Stock Options that are scheduled to vest by the end of the calendar
         year in which such termination occurs shall be accelerated and deemed
         to have vested as of the termination date. All Stock Options that have
         not vested (or been deemed pursuant to the immediately preceding
         sentence to have vested) as of the date of termination shall be deemed
         to have expired as of such date.

                  (e) This Section 7.6 sets forth the only obligations of the
         Company with

                                       7
<PAGE>

         respect to the termination of the Consultant's agreement with the
         Company, and the Consultant acknowledges that, upon the termination of
         this Agreement, he shall not be entitled to any payments or benefits
         which are not explicitly provided in Section 7.6.

                  (f) Upon termination of this Agreement for any
         reason, the Consultant shall be deemed to have resigned as director of
         the Company, effective as of the date of such termination.

                  (g) The provisions of this Section 7.6 shall survive
         any termination of this Agreement.

         8.   NON-COMPETITION, NON-SOLICITATION AND NON-DISPARAGEMENT.

              8.1 The Consultant agrees, understands and recognizes that,
due to the unique nature of the Company's business, the loss of any of its
clients or business flow, the improper use of its Confidential and Proprietary
Information, or the loss of access to the Consultant's knowledge, skills and
know-how could create significant instability and cause substantial damage to
the Company and its affiliates and therefore the Company has a strong legitimate
business interest in protecting the continuity of its business interests and the
restriction herein agreed to by the Consultant narrowly and fairly serves such
an important and critical business interest of the Company. For purposes of this
Agreement, the Company shall be deemed to be actively in the business of chiral
chemistry, including the development, application, and manufacturing of
catalysts used to develop and manufacture chiral molecules and providing
consulting services in connection therewith, and in the future, in any other
business in which it actually devotes substantive resources to study, develop or
pursue during the Term. During the Term and for a period of two (2) years
thereafter, the Consultant shall not, directly or indirectly:

                  (a) solicit or induce any employee of the Company or
         any of its affiliates to leave the employ of the Company or any such
         affiliate; or hire for any purpose any employee of the Company or any
         affiliate or any employee who has left the employment of the Company or
         any affiliate within two years of the termination of such employee's
         employment with the Company or any such affiliate or at any time in
         violation of such employee's non-competition agreement with the Company
         or any such affiliate; or

                  (b) solicit or accept employment or be retained by any person,
         company, entity, or party who, at any time during the term of this
         Agreement, was an agent, client or customer of the Company or any of
         its affiliates where his position will be related to the business of
         the Company or any such affiliate;

                  (c) solicit or accept the business of any agent, client or
         customer of the Company or any of its affiliates with respect
         to products, services or investments similar to those provided or
         supplied by the Company or any of its affiliates; or

                  (d) compete with the Company in the business of the Company,
         either individually or in conjunction with any person, firm,
         association, syndicate, partnership, company or corporation, directly
         or indirectly (as principal, agent, employee, director, officer,
         shareholder, partner, independent contractor, consultant, individual
         proprietor, or as an investor who has made advances, loans, or
         contributions of capital, or in any other manner whatsoever).

              8.2 The Company and the Consultant each agree that both during
the Term and at all times thereafter, neither party shall directly or indirectly
disparage, whether or not true, the name or reputation of the other party or any
of its affiliates, including but not limited to, any officer, director, employee
or shareholder of the Company or any of its affiliates.

                                       8
<PAGE>

              8.3 In the event that the Consultant breaches any provisions
of Section 4 or this Section 8 or there is a threatened breach, then, in
addition to any other rights which the Company may have, the Company shall be
entitled, to injunctive and other equitable relief for such breach or threatened
breach and that resort by the Company to such injunctive or equitable relief
shall not be deemed to waiver or to limit in any respect any right or remedy
which the Company may have with respect to such breach or threatened breach. The
Consultant agrees that in such action, if the Company makes a prima facie
showing that Consultant has violated or apparently intends to violate any of the
provisions of this Section 8, the Company need not prove either damage or
irreparable injury in order to obtain injunctive relief. The Company and
Consultant agree that any such action for injunctive or equitable relief shall
be heard in a state or federal court situated in the County and State of New
York and each of the parties hereto agrees to accept service of process by
registered or certified mail and to otherwise consent to the jurisdiction of
such courts.

              8.4 Each of the rights and remedies enumerated in this Section
8 shall be independent of the others and shall be in addition to and not in lieu
of any other rights and remedies available to the Company at law or in equity.
If any of the covenants contained in this Section 8, or any part of any of them,
is hereafter construed or adjudicated to be invalid or unenforceable, the same
shall not affect the remainder of the covenant or covenants or rights or
remedies which shall be given full effect without regard to the invalid
portions. If any of the covenants contained in this Section 8 is held to be
invalid or unenforceable because of the duration of such provision or the area
covered thereby, the parties agree that the court making such determination
shall have the power to reduce the duration and/or area of such provision and in
its reduced form such provision shall then be enforceable. No such holding of
invalidity or unenforceability in one jurisdiction shall bar or in any way
affect the Company's right to the relief provided in this Section 8 or otherwise
in the courts of any other state or jurisdiction within the geographical scope
of such covenants as to breaches of such covenants in such other respective
states or jurisdictions, such covenants being, for this purpose, severable into
diverse and independent covenants.

              8.5 In the event that an actual proceeding is brought in
equity to enforce the provisions of Section 4 or this Section 8, the Consultant
shall not urge as a defense that there is an adequate remedy at law nor shall
the Company be prevented from seeking any other remedies which may be available.
The Consultant agrees that he shall not raise in any proceeding brought to
enforce the provisions of Section 4 or this Section 8 that the covenants
contained in such Sections limit his ability to earn a living.

              8.6 The provisions of this Section 8 shall survive any
termination of this Agreement.

         9.   NO MITIGATION. You will not be required to mitigate the amount of
any payment or benefit provided in this Agreement by seeking other employment or
otherwise, and there will be no offsets against amounts due you under this
Agreement or account of any remuneration attributable to any subsequent
employment that you may obtain.

         10.  ARBITRATION.

         Except with respect to any proceeding brought under Section 8 hereof,
any controversy, claim, or dispute between the parties, directly or indirectly,
concerning this Employment Agreement or the breach

                                       9
<PAGE>

hereof, or the subject matter hereof, including questions concerning the scope
and applicability of this arbitration clause, shall be finally settled by
arbitration in the State of New York pursuant to the rules then applying of the
American Arbitration Association, JAMS or such other association as may be
mutually agreed upon by the parties. The arbitrators shall consist of one
representative selected by the Company, one representative selected by the
Consultant and one representative selected by the first two arbitrators. The
parties agree to expedite the arbitration proceeding in every way, so that the
arbitration proceeding shall be commenced within thirty (30) days after request
therefore is made, and shall continue thereafter, without interruption, and that
the decision of the arbitrators shall be handed down within thirty (30) days
after the hearings in the arbitration proceedings are closed. The arbitrators
shall have the right and authority to assess the cost of the arbitration
proceedings and to determine how their decision or determination as to each
issue or matter in dispute may be implemented or enforced. The decision in
writing of any two of the arbitrators shall be binding and conclusive on all of
the parties to this Agreement. Should either the Company or the Consultant fail
to appoint an arbitrator as required by this Section 10 within thirty (30) days
after receiving written notice from the other party to do so, the arbitrator
appointed by the other party shall act for all of the parties and his decision
in writing shall be binding and conclusive on all of the parties to this
Agreement. Any decision or award of the arbitrators shall be final and
conclusive on the parties to this Agreement; judgment upon such decision or
award may be entered in any competent Federal or state court located in the
United States of America; and the application may be made to such court for
confirmation of such decision or award for any order of enforcement and for any
other legal remedies that may be necessary to effectuate such decision or award.

         11.  NOTICES.

         All notices, requests, consents and other communications required or
permitted to be given hereunder, shall be in writing and shall be deemed to have
been duly given if delivered personally or sent by facsimile or mailed
first-class, postage prepaid, by registered or certified mail (notices sent by
mail shall be deemed to have been given on the date sent), to the parties at
their respective addresses hereinabove set forth or to such other address as
either party shall designate by notice in writing to the other in accordance
herewith. Copies of all notices shall be sent to each party at the address first
set forth above; provided, however, that the Company shall provide notice to the
Consultant by delivering notice to:

Steven Eckhaus
Eckhaus & Olson
230 Park Avenue
New York, NY 10169-2525
(212) 986-6200 tel
(212) 661-2153 fax
sge@eckhausolson.com

         12.  GENERAL.

              12.1  GOVERNING LAW.  This Agreement shall be governed by and
construed and enforced in accordance with the local laws of the State of New
York applicable to agreements made and to be performed entirely in New York.

              12.2  CAPTIONS.  The section headings contained herein are for
reference purposes only and shall not in any way affect the meaning or
interpretation of this Agreement.

              12.3  ENTIRE AGREEMENT. This Agreement sets forth the entire
agreement and understanding of the parties relating to the subject matter
hereof, and supersedes all prior agreements, arrangements and understandings,
written or oral, relating to the subject matter hereof. No

                                       10

<PAGE>

representation, promise or inducement has been made by either party that is not
embodied in this Agreement, and neither party shall be bound by or liable for
any alleged representation, promise or inducement not so set forth.

              12.4  SEVERABILITY. If any of the provisions of this Agreement
shall be unlawful, void, or for any reason, unenforceable, such provision shall
be deemed severable from, and shall in no way affect the validity or
enforceability of, the remaining portions of this Agreement.

              12.5  WAIVER. The waiver by any party hereto of a breach of any
provision of this Agreement by any other party shall not operate or be construed
as a waiver of any subsequent breach of the same provision or any other
provision hereof.

              12.6  COUNTERPARTS. This Agreement may be executed in one or
more counterparts, each of which shall be deemed an original, but all of which
taken together shall constitute one and the same Agreement.

              12.7  ASSIGNABILITY. This Agreement, and Consultant's rights
and obligations hereunder, may not be assigned by Consultant. The Company may
assign its rights, together with its obligations, hereunder in connection with
any sale, transfer or other disposition of all or substantially all of its
business or assets; in any event the rights and obligations of the Company
hereunder shall be binding on its successors or assigns, whether by merger,
consolidation or acquisition of all or substantially all of its business or
assets.

              12.8  AMENDMENT. This Agreement may be amended, modified,
superseded, canceled, renewed or extended and the terms or covenants hereof may
be waived, only by a written instrument executed by both of the parties hereto,
or in the case of a waiver, by the party waiving compliance. No superseding
instrument, amendment, modification, cancellation, renewal or extension hereof
shall require the consent or approval of any person other than the parties
hereto. The failure of either party at any time or times to require performance
of any provision hereof shall in no matter affect the right at a later time to
enforce the same. No waiver by either party of the breach of any term or
covenant contained in this Agreement, whether by conduct or otherwise, in any
one or more instances, shall be deemed to be, or construed as, a further or
continuing waiver of any such breach, or a waiver of the breach of any other
term or covenant contained in this Agreement.

         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

CHIRAL QUEST, INC.                          XUMU ZHANG, PH.D.

By: /s/ Alan Roth                           By: /s/ Xumu Zhang
    ----------------------                     -----------------------
Name:    Alan Roth
Title:   President & CEO

                                       11

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