Document:

Exhibit

	
															
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT
	1.   CONTRACT ID CODE
	PAGE   OF   PAGES

	1
	2
	 

	2.  AMENDMENT/MODIFICATION NO.
	3.  EFFECTIVE DATE
	4.  REQUISITION/PURCHASE REQ. NO.
	 5.  PROJECT NO. (if applicable)

	0038
	See Block 16C
	N/A.
	 

	6.  ISSUED BY
	CODE
	ASPR-BARDA
	7.  ADMINISTERED BY (If other than Item 6)

	CODE
	ASPR-BARDA02

	ASPR-BARDA
200 Independence Ave., S.W.
Room 640-G
Washington DC 20201

	ASPR-BARDA
330 Independence Ave, SW, Rm G640
Washington DC 20201

	8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)
	x
	9A.  AMENDMENT OF SOLICITATION NO.

	

CHIMERIX, INC. 1377270
CHIMERIX, INC.   2505   MERIDIAN P
2505 MERIDIAN PKWY STE 340
DURHAM NC 277135246
	 
	 

	 9B.  DATED (SEE ITEM 11)

	 
	 

	x
	 10A.  MODIFICATION OF CONTRACT/ORDER NO.
 HHSO100201100013C

	 

	 10B.  DATED (SEE ITEM 13)
02/16/2011

	CODE
1377270
	FACILITY CODE
	 

	11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

	o   The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers   o  is extended.    o is not extended
Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning ___________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT 
THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by    
virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes    
reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

	12.  ACCOUNTING AND APPROPRIATION DATA (if required)
 N/A.                                                                                                                                                            

	13.  THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	CHECK ONE
	A.   THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority)  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

	 

	 
	B.   THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

	 
	C.   THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

	X
	D.   OTHER (Specify type of modification and authority)
Bilateral:  Mutual Agreement of the Parties.

	E.  IMPORTANT:   Contractor   o  is not.   x  is required to sign this document and return            0    copies to the issuing office.

	14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

	Tax ID Number:   33-0903395
DUNS Number:   121785997

A. The purpose of this modification is to incorporate the following changes into the
contract:

1. Under Contract Number HHS0100201100013C in SECTION G - CONTRACT ADMINISTRATION DATA,
under Article G.10. Government Property, the following is hereby added as Paragraph 4. and
titled "Disposition Instructions" as follows :

 4. Disposition Instructions

	

Continued . . .
Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

	15A.  NAME AND TITLE OF SIGNER (Type or print)
	 16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

	Timothy W. Trost, SVP & CFO
	ETHAN J. MUELLER

	15B.  CONTRACTOR/OFFEROR
	15C.  DATE SIGNED
	16B.  UNITED STATES OF AMERICA
	16C.  DATE SIGNED

	   /s/ Timothy W. Trost
       (Signature of person authorized to sign)
	4/13/17
	   /s/ Ethan J. Mueller   
             (Signature of Contracting Officer)
	4/3/17

NSN 7540-01-152-8070    STANDARD FORM 30 (REV. 10-83)
Previous edition unusable    Prescribed by GSA
FAR (48 CFR) 53.243

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0038
	PAGE   OF

	2
	2

	NAME OF OFFEROR OR CONTACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	Title for three 100 kg scale CMX00l final bulk drug substance (BDS) engineering
batches under CLIN 0004 Only under Contract Number HHSO100201100013C that are no
longer needed by the Government and have no commercial market value will hereby vest 
with the Contractor.

2. In signing this no cost bilateral modification, the Contractor hereby certifies
for both Chimerix and any of its subcontractors at any tier that the three 100 kg
scale CMX00l final bulk drug substance (BOS) engineering batches under CLIN 0004
Only under Contract Number HHSO100201100013C that are no longer needed by the
Government and have no commercial value that the Government will be turning 
Title over to the Contractor will not be repurposed for use under any efforts nor
Disposed of in any methods that are prohibited by any federal, state and local laws
and regulations and will not result in any costs being incurred under both Contract
Number HHS0100201100013C and under any other U.S. Government contracts and in
signing this no cost bilateral modification, the Contractor also hereby certifies 
for both Chimerix and any of its subcontractors at any tier that the three 100 kg
scale CMX00l final bulk drug substance (BDS) engineering batches under CLIN 0004
Only under Contract Number HHSO100201100013C that are no longer needed by
Government and have no commercial market value that the Government will be turning
title over to the Contractor will not be repurposed for the performance of any other 
efforts that are under the scope of Contract Number HHSO100201100013C nor under any
other Government contracts by either Chimerix or any of its subcontractors at any
tier and will not result in any costs being incurred under both Contract Number
HHSO100201100013C and under any other U.S. Government contracts.

3. The total amount, scope and period of performance of all other CLINs that are 
currently being performed under the contract remain unchanged. This modification 
does not exercise any unexercised Option CLINs under the contract and does not 
authorize any performance of efforts under any unexercised Option CLINs under the 
contract. In addition, the total amount, scope and period of performance of all 
unexercised Option CLINs under the contract remain unchanged. This modification 
also confirms that all activities under the base period of performance CLIN 0001 
were completed as of 31 May 2013 and confirms that all activities under the Option 
l/CLIN 0002 period of performance were completed as of 30 April 2015.

B. This is a no cost bilateral modification. All other terms and conditions of
Contract Number HHSO100201100013C remain unchanged.

Period of Performance: 02/16/2011 to 06/30/2017

NSN 7540-01-152-8067                                          OPTIONAL FORM 336 (4-86)
     Sponsored by GSA
FAR (48 CFR) 53.110Exhibit

	
															
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT
	1.   CONTRACT ID CODE
	PAGE   OF   PAGES

	1
	2
	 

	2.  AMENDMENT/MODIFICATION NO.
	3.  EFFECTIVE DATE
	4.  REQUISITION/PURCHASE REQ. NO.
	 5.  PROJECT NO. (if applicable)

	0039
	See Block 16C
	N/A.
	 

	6.  ISSUED BY
	CODE
	ASPR-BARDA
	7.  ADMINISTERED BY (If other than Item 6)

	CODE
	ASPR-BARDA02

	ASPR-BARDA
200 Independence Ave., S.W.
Room 640-G
Washington DC 20201

	ASPR-BARDA
330 Independence Ave, SW, Rm G640
Washington DC 20201

	8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)
	x
	9A.  AMENDMENT OF SOLICITATION NO.

	

CHIMERIX, INC. 1377270
CHIMERIX, INC.   2505   MERIDIAN P
2505 MERIDIAN PKWY STE 340
DURHAM NC 277135246
	 
	 

	 9B.  DATED (SEE ITEM 11)

	 
	 

	x
	 10A.  MODIFICATION OF CONTRACT/ORDER NO.
 HHSO100201100013C

	 

	 10B.  DATED (SEE ITEM 13)
02/16/2011

	CODE
1377270
	FACILITY CODE
	 

	11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

	o   The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers   o  is extended.    o is not extended
Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning ___________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT 
THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by    
virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes    
reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

	12.  ACCOUNTING AND APPROPRIATION DATA (if required)
 N/A.                                                                                                                                                            

	13.  THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	CHECK ONE
	A.   THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority)  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

	 

	 
	B.   THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

	 
	C.   THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

	X
	D.   OTHER (Specify type of modification and authority)
Bilateral:  Mutual Agreement of the Parties.

	E.  IMPORTANT:   Contractor   o  is not.   x  is required to sign this document and return            0    copies to the issuing office.

	14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

	Tax ID Number:   33-0903395
DUNS Number:   121785997

A. The purpose of this modification is to incorporate the following changes into the
contract:

1. Under Contract Number HHS0100201100013C in SECTION G - CONTRACT ADMINISTRATION DATA,
under Article G.10. Government Property, the following is hereby added as Paragraph 5. and
titled "Disposition Instructions" as follows :

 5. Disposition Instructions

	

Continued . . .
Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

	15A.  NAME AND TITLE OF SIGNER (Type or print)
	 16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

	Timothy W. Trost, SVP & CFO
	ETHAN J. MUELLER

	15B.  CONTRACTOR/OFFEROR
	15C.  DATE SIGNED
	16B.  UNITED STATES OF AMERICA
	16C.  DATE SIGNED

	   /s/ Timothy W. Trost
       (Signature of person authorized to sign)
	5/8/17
	   /s/ Ethan J. Mueller   
             (Signature of Contracting Officer)
	5/11/17

NSN 7540-01-152-8070    STANDARD FORM 30 (REV. 10-83)
Previous edition unusable    Prescribed by GSA
FAR (48 CFR) 53.243

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0039
	PAGE   OF

	2
	2

	NAME OF OFFEROR OR CONTACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	Title for three 120 kg scale CMX212 intermediate validation batches under CLIN 0004 
Only under Contract Number HHSO100201100013C that are no longer needed by the 
Government and have no commercial market value will hereby vest with the Contractor.

2. In signing this no cost bilateral modification, the Contractor hereby certifies
for both Chimerix and any of its subcontractors at any tier that the three 120 kg
scale CMX212 intermediate validation batches under CLIN 0004 Only under Contract 
Number HHSO100201100013C that are no longer needed by the Government and have no 
commercial value that the Government will be turning title over to the 
Contractor will not be repurposed for use under any efforts nor disposed of in any 
methods that are prohibited by any federal, state and local laws and regulations and 
will not result in any costs being incurred under both Contract Number 
HHS0100201100013C and under any other U.S. Government contracts and in signing this 
no cost bilateral modification, the Contractor also hereby certifies for both 
Chimerix and any of its subcontractors at any tier that the three 120 kg scale
CMX212 intermediate validation batches under CLIN 0004 Only under Contract Number
HHSO100201100013C that are no longer needed by the Government and have no commercial
market value that the Government will be turning title over to the Contractor will
not be repurposed for the performance of any other efforts that are under the scope 
of Contract Number HHSO100201100013C nor under any other Government contracts by 
either Chimerix or any of its subcontractors at any tier and will not result in any 
costs being incurred under both Contract Number HHSO100201100013C and under 
any other U.S. Government contracts.

3. The total amount, scope and period of performance of all other CLINs that are 
currently being performed under the contract remain unchanged. This modification 
does not exercise any unexercised Option CLINs under the contract and does not 
authorize any performance of efforts under any unexercised Option CLINs under the 
contract. In addition, the total amount, scope and period of performance of all 
unexercised Option CLINs under the contract remain unchanged. This modification 
also confirms that all activities under the base period of performance CLIN 0001 
were completed as of 31 May 2013 and confirms that all activities under the Option 
l/CLIN 0002 period of performance were completed as of 30 April 2015.

B. This is a no cost bilateral modification. All other terms and conditions of
Contract Number HHSO100201100013C remain unchanged.

Period of Performance: 02/16/2011 to 06/30/2017

NSN 7540-01-152-8067                                          OPTIONAL FORM 336 (4-86)
     Sponsored by GSA
FAR (48 CFR) 53.110

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