Document:

Exhibit
10.06

     

     

    THIS NOVATION
AGREEMENT is made the 11th day of April, 2008

     

    BETWEEN:

     

    
      	
              1.

            	
              SHIRE PLC of Hampshire
      International Business Park, Chineham, Basingstoke, Hampshire RG24 8EP
      (registered in England No. 5492592) (“Old Shire”)

            
	 	 
	
              2.

            	
              SHIRE LIMITED of 22
      Grenville Street, St. Helier, Jersey, JE4 8PX (registered in Jersey No.
      99854) (“New
      Shire”)

            
	 	 
	
              AND

            
	 	 
	
              3.

            	
              ANGUS RUSSELL of
      Hampshire International Business Park, Chineham, Basingstoke, Hampshire
      RG24 8EP (the “Director”)

            
	 
	
              WHEREAS:

            

    

     

    
      	 	
              (A)

            	
              Old Shire is
      proposing to enter into the Scheme of Arrangement (as defined below);
      and

            
	 	 	 
	 	
              (B)

            	
              Upon the
      Scheme of Arrangement becoming effective, Old Shire wishes to be released
      and discharged from the Contract (as defined below) and the Director has
      agreed to release and discharge Old Shire from the Contract upon the terms
      of New Shire’s undertaking to perform the Contract and be bound by its
      terms in the place of Old Shire.

            

    

     

    
      	
              NOW IT IS
      AGREED as follows:-

            
	 	 
	
              1.

            	
              INTERPRETATION

            
	 	 
	
              1.1

            	
              In this
      agreement (including in its
recitals):

            

    

     

    
      	 
    	
              “Contract”

            	
              means the
      contract relating to the employment of the Director as Group Finance
      Director for the Old Shire group made between SPG (1) and the Director (2)
      and dated 10 March 2004 (as novated to Old Shire pursuant to a novation
      agreement dated 21 November 2005), a copy of which is scheduled
      hereto;

            
	 	 	 
	 
    	
              “Effective
      Date”

            	
              means the date
      upon which the Scheme of Arrangement becomes effective in accordance with
      its terms;

            
	 	 	 
	 
    	
              “Scheme
      of Arrangement”

            	
              means the
      Scheme as defined in a circular to Old Shire shareholders dated on or
      about 16th
      April 2008; and

            
	 	 	 
	 
    	
              “SPG”

            	
              means Shire
      Pharmaceuticals Group plc.

            

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	
              1.2

            	
              In this
      agreement, unless otherwise specified:

            
	 	 	 
	 
    	
              (A)

            	
              references to
      Clauses and sub-clauses are to clauses and sub-clauses of this agreement;
      and

            
	 	 	 
	 
    	
              (B)

            	
              headings to
      Clauses and the schedule to this agreement are for convenience only and do
      not affect the interpretation of this agreement.

            
	 	 
	
              2.

            	
              CONDITIONS

            

    

     

    
      	 
    	
              The rights and
      obligations of the parties to this agreement shall be conditional in their
      entirety upon the Scheme of Arrangement becoming
  effective.

            
	 	 
	
              3.

            	
              NEW
      SHIRE’S UNDERTAKING

            
	 	 
	
              3.1

            	
              With effect
      from the Effective Date and in consideration of the undertaking given by
      the Director in Clause 4, New Shire hereby undertakes to observe, perform,
      discharge and be bound by the Contract as if New Shire were a party to the
      Contract in the place of Old Shire.

            
	 	 
	
              3.2

            	
              Notwithstanding
      the undertaking in Clause 3.1, nothing in this agreement shall require New
      Shire to perform, or make New Shire liable in respect of, any obligation
      created by or arising under the Contract falling due for performance, or
      which should have been performed, before the Effective
    Date.

            
	 	 
	
              3.3

            	
              For the
      avoidance of doubt, New Shire hereby undertakes to be responsible for all
      accruals of the Director’s salary or other benefits with effect from and
      including the Effective Date.

            
	 	 
	
              4.

            	
              DIRECTOR’S
      UNDERTAKING AND RELEASE OF OLD SHIRE

            
	 	 
	
              4.1

            	
              With effect
      from the Effective Date and in consideration of the undertakings given by
      New Shire in Clause 3 and Old Shire in Clause 5, the Director hereby
      releases and discharges Old Shire from all obligations to observe,
      perform, discharge and be bound by the Contract and agrees to observe,
      perform, discharge and be bound by the Contract as if New Shire were a
      party to the Contract in the place of Old Shire.

            
	 	 
	
              4.2

            	
              Notwithstanding
      the provisions of Clause 4.1, nothing in this agreement shall affect or
      prejudice any claim or demand whatsoever which the Director may have
      against Old Shire in relation to the Contract and arising out of matters
      prior to the Effective Date.

            
	 	 
	
              5.

            	
              OLD
      SHIRE’S UNDERTAKING AND RELEASE OF DIRECTOR

            
	 	 
	 
    	
              With effect
      from the Effective Date and in consideration of the undertaking given by
      the Director in Clause 4.1, Old Shire hereby releases and discharges the
      Director from all obligations to observe, perform, discharge and be bound
      by the Contract.  Notwithstanding this undertaking and release,
      nothing in this agreement shall affect
or

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	 
    	
              prejudice any
      claim or demand whatsoever which Old Shire may have against the Director
      in relation to the Contract and arising out of matters prior to the
      Effective Date.

            
	 	 
	
              6.

            	
              EMPLOYMENT
      RIGHTS ACT 1996

            
	 	 
	 
    	
              For the
      purposes of Section 1 of the Employment Rights Act 1996, with effect from
      the Effective Date, the Director will be employed by New
      Shire.  The Director’s period of continuous employment is
      unaffected by this change.

            
	 	 
	
              7.

            	
              ENTIRE
      AGREEMENT

            
	 	 
	 
    	
              This agreement
      constitutes the whole and only agreement between the parties relating to
      the subject matter of this agreement.  Each party acknowledges
      that, in entering into this agreement, it is not relying on any
      pre-contractual statement which is not set out in this
      agreement.

            
	 	 
	
              8.

            	
              COUNTERPARTS

            
	 	 
	
              8.1

            	
              This agreement
      may be executed in any number of counterparts, and by the parties on
      separate counterparts, but shall not be effective until each party has
      executed at least one counterpart.

            
	 	 
	
              8.2

            	
              Each
      counterpart shall constitute an original of this agreement, but all the
      counterparts shall together constitute but one and the same
      instrument.

            
	 	 
	
              9.

            	
              GOVERNING
      LAW AND JURISDICTION

            
	 	 
	 
    	
              This agreement
      shall be governed by and construed in accordance with English law and the
      courts of England are to have jurisdiction to settle any dispute arising
      out of or in connection with this agreement.  Any proceeding,
      suit or action arising out of, or in connection with, this agreement may
      be brought in the English courts.

            

       

    

    
    

     

    
      	/s/ Patrick
  Langlois
	

              For and on
      behalf of

              SHIRE
      PLC

            
	 

    

     

    
      
        	/s/ Angus Russell
	

                For and on
      behalf of SHIRE
      PLC

              
	 

      

    

     

    
      
        	/s/ Angus Russell
	

                ANGUS
      RUSSELL

              
	 

      

       

    

     

    CE080850030

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    

     

    SCHEDULEExhibit
10.07

     

    THIS AGREEMENT is made on
the       day
of                             2008

     

    BETWEEN:

     

    
      	
              (1)

            	
              SHIRE LIMITED, a company
      incorporated in Jersey (registered number 99854) whose registered office
      is at 22 Grenville Street, St Hellier, Jersey JE4 8PX (the “Company”);
      and

            

    

     

    
      	
              (2)

            	
              «NAMEOFDIRECTOR»,
      of Hampshire
      International Business Park, Basingstoke, Hampshire RG24 8EP (the “Director”).

            

    

     

    WHEREAS:

     

    
      	
              (A) 

            	
              The Director
      is a director of the Company on the date of this
  Agreement.

            

    

     

    
      	
              (B)

            	
              The Company
      has agreed to indemnify the Director, and the Director has agreed to give
      certain undertakings to the Company, in each case on the terms of and
      subject to the conditions of this
Agreement.

            

    

     

    
      	
               
      

            	
              THIS AGREEMENT PROVIDES
      as follows:

            

    

     

    
      
        	
                1.

              	
                INTERPRETATION

              

      

    

     

    
      	
              1.1

            	
              In this
      Agreement:

            

    

     

    
      	
               
      

            	
              (A)

            	
              “Associated
      Company”
      means any Subsidiary of the Company, any holding company of the
      Company (if created) and any Subsidiary of that holding company (if
      created);

            

    

     

    
      	
               
      

            	
              (B)

            	
              “Companies
      Law” means the Companies (Jersey) Law
  1991;

            

    

     

    
      	
               
      

            	
              (C)

            	
              “Subsidiary” means any subsidiary
      of the Company, as defined in the Companies
Law;

            

    

     

    
      	
               
      

            	
              (D)

            	
              references to
      Clauses and sub-clauses are to clauses and sub-clauses of this
      Agreement;

            

    

     

    
      	
               
      

            	
              (E)

            	
              use of any
      gender includes the other genders;

            

    

     

    
      	
               
      

            	
              (F)

            	
              a reference to
      any statute or statutory provision shall be construed as a reference to
      the same as it may have been, or may from time to time be, amended,
      modified or re-enacted; and

            

    

     

    
      	
               
      

            	
              (G)

            	
              headings and
      titles are inserted for convenience only and are to be ignored in the
      interpretation of this Agreement.

            

    

     

    
      	
              1.2

            	
              If there is
      any inconsistency between the provisions of this Agreement and the
      provisions of any contract of employment or terms of appointment in effect
      on the date of this Agreement between the Director and the Company, the
      provisions of this Agreement shall
prevail.

            

    

     

    
      
        
        

      

      
        - 1 -

        
          

        

      

      
        
        

      

    

     

    
      	
              2.

            	
              INDEMNITIES

            

    

     

    
      	
              2.1

            	
              Claims
      by Third Parties

            

    

     

    Subject to Clauses
2.2, 2.5 and 2.6, the Company undertakes to indemnify the Director against any
liability suffered or incurred by the Director on or after the date of this
Agreement:

     

    
      	
               
      

            	
              (A)

            	
              in respect of
      the Director’s acts or omissions (whether before, on or after the date of
      this Agreement) while, or in the course of acting as, a director or
      employee of the Company or a director or employee of any Subsidiary;
      and/or

            

    

     

    
      	
               
      

            	
              (B)

            	
              which
      otherwise arise by virtue of the Director holding or having held such
      office;

            

    

     

    in
each case, to the extent arising out of or in connection with, directly or
indirectly, any claim, action or proceedings brought against the Director or any
other person by or on behalf of any third party (not being the Company or an
Associated Company) in any jurisdiction in respect of any alleged loss,
liability or damage actually or allegedly suffered by any third party, the
Company or an Associated Company.

     

    
      	
              2.2

            	
              Scope
      of Indemnity for Claims by Third
Parties

            

    

     

    The
indemnity in Clause 2.1 shall not apply to any liability incurred by the
Director:

     

    
      	
               
      

            	
              (A)

            	
              to pay a fine
      imposed in criminal proceedings;

            

    

     

    
      	
               
      

            	
              (B)

            	
              to pay a sum
      payable to a regulatory authority by way of a penalty in respect of
      non-compliance with any requirement of a regulatory
  nature;

            

    

     

    
      	
               
      

            	
              (C)

            	
              in defending
      any criminal proceedings in which he is
  convicted;

            

    

     

    
      	
               
      

            	
              (D)

            	
              in connection
      with any application made under Article 212 of the Companies Law in
      connection with which the court refuses to grant him relief;
      and

            

    

     

    
      	
               
      

            	
              (E)

            	
              unless, in
      connection with the matters giving rise to the liability, the Director
      acted in good faith with a view to the best interests of the Company, or
      in connection only with any liability incurred in defending civil
      proceedings (regardless of whether the Director has acted in good faith
      with a view to the best interests of the Company), judgment is given in
      favour of the Director.

            

    

     

    
      	
              2.3

            	
              Claims
      by or on behalf of the Company or an Associated
  Company

            

    

     

    Subject to Clauses
2.4, 2.5 and 2.6, the Company undertakes to indemnify the Director against any
liability incurred by him as a director in defending any civil or criminal
claim, action or proceedings which relate to anything done or omitted, or
claimed to have been done or omitted, by him which are brought against the
Director or any other person by or on behalf of the Company or an Associated
Company.

     

    
      
        
        

      

      
        - 2 -

        
          

        

      

      
        
        

      

    

     

    
      	
              2.4

            	
              Exclusions
      from Indemnity for Claims by or on behalf of the Company or an Associated
      Company

            

    

     

    The
indemnity in Clause 2.3 shall not apply to any liability:

     

    
      	
               
      

            	
              (A)

            	
              (for the
      avoidance of doubt) incurred by the Director to the Company or an
      Associated Company;

            

    

     

    
      	
               
      

            	
              (B)

            	
              incurred by
      the Director in defending any criminal proceedings in which he is
      convicted;

            

    

     

    
      	
               
      

            	
              (C)

            	
              incurred by
      the Director in defending any civil proceedings in which judgment is given
      against him; and

            

    

     

    
      	
               
      

            	
              (D)

            	
              incurred by
      the Director in connection with any application made under Article 212 of
      the Companies Law in which the court refuses to grant him
      relief.

            

    

     

    
      	
              2.5

            	
              Funding
      of Expenditure

            

    

     

    
      	
               
      

            	
              (A)

            	
              Subject to the
      provisions of this Agreement, the Company agrees to loan to the Director,
      on an interest free basis, such funds as may be required to meet any
      expenditure incurred or to be incurred by him, in defending any claim,
      action or proceedings falling within the scope of such claims, actions, or
      proceedings as are covered by the provisions of Clause 2.1 and
      2.3.

            

    

     

    
      	
               
      

            	
              (B)

            	
              Subject to
      Clause 2.5(C) below, if the Company loans funds to the Director pursuant
      to Clause 2.5(A) then such loan shall become due and repayable upon any
      conviction of, judgment given against, or refusal of relief to, the
      Director becoming final or the claim, action, or proceeding otherwise
      being settled or terminating.

            

    

     

    
      	
               
      

            	
              (C)

            	
              In the event
      that the liability to which the loan relates can properly be discharged by
      way of indemnity in accordance with Clause 2, the obligation to repay such
      loan will be discharged by way of indemnity in accordance with this Clause
      2.

            

    

     

    
      	
               
      

            	
              (D)

            	
              For purposes
      of this Clause 2.5(B), a conviction, judgment or refusal of relief becomes
      final:

            

    

     

    
      
        	
              	
                (i)

              	
                if not
      appealed against, at the end of the period for bringing an appeal;
      or

              

      

    

     

    
      
        	
              	
                (i)

              	
                if appealed
      against, at the time when the appeal (or any further appeal) is determined
      and the period for bringing any further appeal has ended or if the appeal
      is abandoned or otherwise ceases to have
effect.

              

      

    

     

    
      	
              2.6

            	
              Limitations
      on indemnity

            

    

     

    Without prejudice to
any other rights or remedies which may be available to the Director, the
indemnity granted by the Company to the Director in either Clause 2.1 or Clause
2.3 

     

     

    
      
        
        

      

      
        - 3 -

        
          

        

      

      
        
        

      

    

     

    shall not apply to
the extent that it is not permitted by, or consistent with, law or statute from
time to time in force (including, without limitation, the Companies Law), the
memorandum and articles of the Company or the rules and regulations of any
regulatory body.

     

    
      	
              3.

            	
              Conduct
      of Claims and Access to Information

            

    

     

    
      	
              3.1

            	
              Without
      prejudice to the sub-clause 3.2, if the Director becomes aware of any
      claim, action or demand against him which could give rise to any claim,
      action or demand by him against the Company under Clause 2.1 (referred to
      herein as a “Third
      Party Claim”), the Director
shall:

            

    

     

    
      	
               
      

            	
              (A)

            	
              within 20 days
      of becoming so aware, notify the Company in writing of the existence of
      such Third Party Claim, giving reasonable details in that notification
      (or, to the extent that such details are not available to the Director at
      that time, as soon as possible thereafter) of the person(s) making such
      Third Party Claim, the circumstances leading to, and the grounds for, that
      Third Party Claim and the quantum or possible quantum of the Third Party
      Claim;

            

    

     

    
      	
               
      

            	
              (B)

            	
              subject to the
      Company agreeing to pay the reasonable out-of-pocket expenses of the
      Director, give such access to premises, chattels, documents and records to
      the Company and its professional advisers as the Company may reasonably
      request;

            

    

     

    
      	
               
      

            	
              (C)

            	
              take such
      action and give such information and assistance in order to avoid,
      dispute, resist, mitigate, settle, compromise, defend or appeal any Third
      Party Claim or judgment or adjudication with respect thereto as the
      Company may reasonably request;

            

    

     

    
      	
               
      

            	
              (D)

            	
              at the request
      of the Company, allow the Company to take the sole conduct of such actions
      as the Company may deem appropriate in connection with any such Third
      Party Claim in the name of the Director and in that connection the
      Director shall give or cause to be given to the Company all such
      assistance as the Company may reasonably require in avoiding, disputing,
      resisting, mitigating, settling, compromising, defending or appealing any
      such Third Party Claim and shall instruct such solicitors or other
      professional advisers as the Company may nominate to act on behalf of the
      Director in relation thereto but to act in accordance with the Company’s
      sole instructions;

            

    

     

    
      	
               
      

            	
              (E)

            	
              make no
      admission of liability, agreement, settlement or compromise with any
      person in relation to any such Third Party Claim without the prior written
      consent of the
Company;  and

            

    

     

    
      	
               
      

            	
              (F)

            	
              take all
      reasonable action to mitigate any loss suffered by him in respect of such
      Third Party Claim.

            

    

     

    
      
        
        

      

      
        - 4 -

        
          

        

      

      
        
        

      

    

     

    
      	
              3.2

            	
              In any event,
      the Company shall be entitled at any stage and at its sole discretion to
      settle any Third Party Claim and shall be under no obligation in this
      respect to notify the Director of its decision so to settle such Third
      Party Claim.

            

    

     

    
      	
              3.3

            	
              If the
      Director intends to make a claim, action or demand against the Company
      under Clause 2.3 (referred to herein as a “Costs
      Claim”) the Director shall:

            

    

     

    
      	
               
      

            	
              (A)

            	
              promptly
      notify the Company in writing of his intention to make such a Costs Claim,
      giving reasonable details in that notification (or, to the extent that
      such details are not available to the Director at that time, as soon as
      possible thereafter) of the grounds for that Costs Claim and the quantum
      or possible quantum of the Costs
Claim;

            

    

     

    
      	
               
      

            	
              (B)

            	
              subject to the
      Company agreeing to pay the reasonable out-of-pocket expenses of the
      Director, take such action and give such information and access to
      premises, chattels, documents and records to the Company and its
      professional advisers as the Company may reasonably
    request;

            

    

     

    
      	
               
      

            	
              (C)

            	
              take all
      reasonable action to mitigate any loss suffered by him in respect of such
      Costs Claim.

            

    

     

    
      	
              4.

            	
              Notices

            

    

     

    
      	
              4.1

            	
              A notice under
      this Agreement shall only be effective if it is in
      writing.  Faxes are permitted. E-mail is not
      permitted.

            

    

     

    
      	
              4.2

            	
              Notices under
      this Agreement shall be sent to a party at its address or number and, in
      the case of the Company, for the attention of the individual, set out
      below:

            

    

     

    
      	
              Party and title of
    individual

            	
              Address

            	
              Fax number

            
	
              Company

              Attention:
      Global General Counsel

            	
              22 Grenville
      Street,

              St
      Hellier,

              Jersey JE4
      8PX

               

              with a copy
      to:

               

              Hampshire
      International Business Park, Basingstoke, Hampshire RG24
    8EP

            	
              +44 1256 894
      710

            
	 	 	 
	
              Director

            	
              Hampshire
      International Business Park, Basingstoke, Hampshire RG24
    8EP

            	 
    

    

    

    
      
        
        

      

      
        - 5 -

        
          

        

      

      
        
        

      

    

     

    
      	
              4.3

            	
              Either party
      may change its notice details on giving notice to the other party of the
      change in accordance with this Clause.  That notice shall only
      be effective on the date falling two Business Days after the notification
      has been received or on such later date as may be specified in the
      notice.

            

    

     

    
      	
              4.4

            	
              Subject to
      sub-clause 4.5 and without prejudice to sub-clause 4.6, any notice given
      under this Agreement shall not be effective until it is received by the
      intended recipient.

            

    

     

    
      	
              4.5

            	
              Any notice
      which is received by its intended recipient under this Agreement outside
      normal working hours in the place to which it is addressed shall be deemed
      to have been given at the start of the next period of normal working hours
      in such place.

            

    

     

    
      	
              4.6

            	
              No notice
      given under this Agreement may be withdrawn or revoked except by notice
      given in accordance with this
Clause.

            

    

     

    
      	
              5.

            	
              Remedies
      and Waivers

            

    

     

    
      	
              5.1

            	
              No delay or
      omission by either party to this Agreement in exercising any right, power
      or remedy provided by law or under this Agreement
  shall:

            

    

     

    
      	
               
      

            	
              (A)

            	
              affect that
      right, power or
remedy;  or

            

    

     

    
      	
               
      

            	
              (B)

            	
              operate as a
      waiver of it.

            

    

     

    
      	
              5.2

            	
              The single or
      partial exercise of any right, power or remedy provided by law or under
      this Agreement shall not preclude any other or further exercise of it or
      the exercise of any other right, power or
  remedy.

            

    

     

    
      	
              5.3

            	
              The rights,
      powers and remedies provided in this Agreement are cumulative and not
      exclusive of any rights, powers and remedies provided by
    law.

            

    

     

    
      	
              6.

            	
              Invalidity

            

    

     

    If
at any time any provision of this Agreement is or becomes illegal, invalid or
unenforceable in any respect under the law of any jurisdiction, that shall not
affect or impair:

     

    
      	
               
      

            	
              (A)

            	
              the legality,
      validity or enforceability in that jurisdiction of any other provision of
      this Agreement;  or

            

    

     

    
      	
               
      

            	
              (B)

            	
              the legality,
      validity or enforceability under the law of any other jurisdiction of that
      or any other provision of this
Agreement.

            

    

     

     

    
      
        
        

      

      
        - 6 -

        
          

        

      

      
        
        

      

    

     

    
      	
              7.

            	
              No
      Partnership

            

    

     

    Nothing in this
Agreement and no action taken by the parties under this Agreement shall
constitute a partnership, association, joint venture or other co-operative
entity between the parties.

     

    
      	
              8.

            	
              Entire
      Agreement

            

    

     

    
      	
              8.1

            	
              This
      Agreement, the Company’s Articles of Association and, subject to Clause
      1.2, any provision of any employment contract or terms of appointment
      under which the Director is, or is entitled to be, indemnified by the
      Company, constitute the whole and only agreement between the parties
      relating to the indemnification of the Director by the Company and the
      obligations of the parties in relation to Third Party Claims and Costs
      Claims.

            

    

     

    
      	
              8.2

            	
              This Agreement
      may only be varied in writing signed by each of the
    parties.

            

    

     

    
      	
              9.

            	
              Assignment

            

    

     

    
      	
              9.1

            	
              The Company
      may at any time assign all or any part of the benefit of, or its rights or
      benefits under, this Agreement to any
  Subsidiary.

            

    

     

    
      	
              9.2

            	
              The Director
      shall not assign, or purport to assign, all or any part of the benefit of,
      or his rights or benefits under, this Agreement, provided that the benefit
      of, and rights under, this Agreement shall ensure to the benefit of, and
      be enforceable by, the successors, heirs and personal representatives of
      the Director.

            

    

     

    
      	
              10.

            	
              Confidentiality

            

    

     

    
      	
              10.1

            	
              Subject to
      Clause 11.3, each party shall treat as confidential all information
      obtained as a result of entering into or performing this Agreement which
      relates to:

            

    

     

    
      	
               
      

            	
              (A)

            	
              the provisions
      of this Agreement;

            

    

     

    
      	
               
      

            	
              (B)

            	
              any
      negotiations relating to this
Agreement;

            

    

     

    
      	
               
      

            	
              (C)

            	
              the subject
      matter of this
Agreement;  or

            

    

     

    
      	
               
      

            	
              (D)

            	
              the other
      party

            

    

     

    (in each case referred to herein as “Confidential
Information”).

     

    
      	
              10.2

            	
              Subject to
      Clause 11.3, each party shall:

            

    

     

    
      	
               
      

            	
              (A)

            	
              not disclose
      any Confidential Information to any person other than any of its
      professional advisers and, in the case of the Company, directors and
      employees and directors and employees of any Subsidiary who need to know
      such information in order to discharge their respective
      duties;  and

            

    

     

     

    
      
        
        

      

      
        - 7 -

        
          

        

      

      
        
        

      

    

     

    
      	
               
      

            	
              (B)

            	
              procure that
      any person to whom any Confidential Information is disclosed by it
      complies with the restrictions contained in this Clause as if such person
      were a party to this Agreement.

            

    

     

    
      	
              10.3

            	
              Notwithstanding
      the other provisions of this Clause, either party may disclose
      Confidential Information:

            

    

     

    
      	
               
      

            	
              (A)

            	
              if and to the
      extent required by law;

            

    

     

    
      	
               
      

            	
              (B)

            	
              in the case of
      the Company, if and to the extent required by any securities exchange or
      regulatory or governmental body to which the Company is subject or
      submits, wherever situated, including (amongst other bodies) the Stock
      Exchange, the Jersey Financial Services Commission, the Financial Services
      Authority or The Panel on Takeovers and Mergers, whether or not the
      requirement for information has the force of
  law;

            

    

     

    
      	
               
      

            	
              (C)

            	
              to its
      professional advisers, and, in the case of the Company, its auditors and
      bankers;

            

    

     

    
      	
               
      

            	
              (D)

            	
              if and to the
      extent the Confidential Information has come into the public domain
      through no fault of that
party;  or

            

    

     

    
      	
               
      

            	
              (E)

            	
              if and to the
      extent the other party has given prior written consent to the disclosure,
      such consent not to be unreasonably withheld or
  delayed.

            

    

     

    Any
Confidential Information to be disclosed by either party pursuant to
paragraph (A), (B), (C) or (D) shall be disclosed only after notice to the
other party.

     

    
      	
              10.4

            	
              The
      restrictions contained in this Clause shall continue to apply after the
      Director ceases to be a director of the Company, without limit in
      time.

            

    

     

    
      	
              11.

            	
              Counterparts

            

    

     

    
      	
              11.1

            	
              This Agreement
      may be executed in any number of counterparts, and by the parties on
      separate counterparts, but shall not be effective until each party has
      executed at least one counterpart.

            

    

     

    
      	
              11.2

            	
              Each
      counterpart shall constitute an original of this Agreement, but all the
      counterparts shall together constitute but one and the same
      instrument.

            

    

     

    
      	
              12.

            	
              Choice
      of Governing Law

            

    

     

    This Agreement is
governed by, and shall be construed in accordance with, Jersey law.

     

     

    
      
        
        

      

      
        - 8 -

        
          

        

      

      
        
        

      

    

     

    
      	
              13.

            	
              Jurisdiction

            

    

     

    The
courts of Jersey are to have jurisdiction to settle any dispute arising out of
or in connection with this Agreement.  Any proceedings relating to
this Agreement may therefore be brought in the Jersey courts.

     

    
      	
              14.

            	
              Process
      agent

            

    

     

    
      	
              14.1

            	
              Without
      prejudice to any other mode of service allowed under Jersey law, the
      Director:

            

    

     

    
      	
               
      

            	
              (A)

            	
              irrevocably
      appoints Mourant & Co Secretaries Limited of 22 Grenville Street, St
      Helier, Jersey JE4 8PX, as its agent for service of process in relation to
      any proceedings before the Jersey courts in connection with this
      Agreement;

            

    

     

    
      	
               
      

            	
              (B)

            	
              agrees that,
      if a process agent ceases to act as process agent or no longer has an
      address in Jersey, it shall appoint a substitute process agent acceptable
      to the Company within ten Business Days and to deliver to the Company a
      copy of the new process agent's acceptance of that appointment, and
      failing this, the Company may appoint another agent for this purpose;
      and

            

    

     

    
      	
               
      

            	
              (C)

            	
              agrees that
      the failure by a process agent to notify him of any process will not
      invalidate the proceedings
concerned.

            

    

     

    
      	
              14.2

            	
              The Company
      shall send by post to the Director a copy of any document served on his
      agent for service of process.  However no failure or delay in so
      doing shall prejudice the effectiveness of service of such document or
      give rise to any claim by the Director against the
  Company.

            

    

     

    IN WITNESS of which this
Agreement has been executed and delivered on the date which first appears on
page 1 above.

     

    
      	
              Company

               

            	 
    
	
              SIGNED for and on behalf
      of

               

              SHIRE
      LIMITED

               

            	
              )

              )

              )

            

    

     

    
 

    
      
        
        

      

      
        - 9 -

        
          

        

      

      
        
        

      

    

     

    
      	
              Director

               

            	 
    
	
              SIGNED by

               

              «NAMEOFDIRECTOR»

               

              in the
      presence of:

            	
              )

              )

              )

              )

            
	 
    	 
    
	
              ...............................................................

            	 
    
	
              Witness

            	 
    
	 
    	 
    
	
              ...............................................................

            	 
    
	
              Address

            	 
    
	 
    	 
    

    

    

     

    CE080650048

     

    

    
      
        
        

      

      
        - 10 -

        
          

        

      

      
        
        

      

    

     

    

     

    
      	
              Dated

            	 
    	
              ,
2008

            

    

     

     

    

     

    SHIRE
LIMITED

     

     

    and

     

     

    «NAMEOFDIRECTOR»

     

     

    _____________________________________________

     

    DIRECTOR’S
INDEMNITY

     

    _____________________________________________

     

     

     

    

     

    Slaughter
and May

    One
Bunhill Row

    London  EC1Y
8YY

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