Document:

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                                                                    Exhibit 10.7

[REDACTED - OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION AND
IS DENOTED HEREIN BY **.]

                                LICENSE AGREEMENT

         LICENSE AGREEMENT, dated as of October 3, 2001, between BRISTOL-MYERS
SQUIBB COMPANY, a Delaware corporation ("BMS"), and PILOT THERAPEUTICS, INC., a
North Carolina corporation ("Pilot").

                             PRELIMINARY STATEMENTS

         A. BMS is the owner of all right, title and interest in and to certain
patents and patent applications covering BMS-270,394.

         B. Pilot wishes to obtain a license from BMS to make, use, offer for
sale and sell products covered by BMS' patents, and BMS is willing to grant to
Pilot such license, on the terms and conditions set forth hereinafter.

         NOW, THEREFORE, in consideration of the mutual covenants and agreements
of the parties hereinafter contained, the parties agree as follows:

                                    ARTICLE 1

                                   DEFINITIONS

         As used in this Agreement, the following terms shall have the meanings
set forth in this Article 1 unless the context dictates otherwise.

         1.1 "Adult" shall mean an individual at least 18 years of age.

         1.2 "Affiliate" of either party shall mean any corporation, partnership
or other entity that directly, or indirectly through one or more intermediaries,
controls, is controlled by or is under common control with such party. "Control"
and, with correlative meanings, the terms "controlled by" and "under common
control with" shall mean both the ownership of at least a majority of the equity
interest, and the power to direct or cause the direction of the management

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and affairs, of the entity in question.

         1.3 "Applicable Royalty Rate", with respect to each Covered Product,
shall mean the percentage rate or rates at which Pilot shall pay royalties to
BMS hereunder in respect of such Covered Product, determined on a calendar
year-by-calendar year basis, as follows:

<TABLE>
<CAPTION>

         Portion of Annual Net Sales                  Applicable Royalty Rate
            of Covered Product(s)                      for Covered Product(s)
         ---------------------------                  -----------------------
         <S>                                          <C>
         <  $50,000,000                                          **%
         -

         > $50,000,000 and < $100,000,000                        **%
                           -

         > $100,000,000 and < $150,000,000                       **%
                            -

         > $150,000,000 and < $200,000,000                       **%
                            -

         > $200,000,000                                          **%

</TABLE>

For the avoidance of doubt, if there is more than one Covered Product sold in
any calendar year, the Net Sales of all Covered Products shall be aggregated for
the purpose of determining the Applicable Royalty Rate.

         1.4 "BMS-270,394" shall mean the chemical compound
(R)-3-fluoro-4(2'(5",6",7",8"-tetrahydro-5",5",8",8"-tetramethyl-2"-naphthyl)-
2'-hydroxy) acetamidobenzoic acid.

         1.5 "BMS Know-How" shall mean all inventions, technical data, knowledge
and other information as of the date hereof owned or controlled by BMS relating
to BMS-270,394, including, without limitation, bulk drug manufacture and drug
formulation know-how, data and results of preclinical studies heretofore
conducted by BMS involving BMS-189,961 and BMS-270,394, any other information as
of the date hereof owned or controlled by BMS relating to BMS-189,961 and
BMS-270,394 which would be useful to Pilot in its seeking of approval from
appropriate governmental health authorities to market any Covered Product, and
any other

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chemical, physical and biological data as of the date hereof owned or
controlled by BMS relating to BMS-270,394 or the manufacture or pharmaceutical
formulation thereof.

         1.6 "Compound" shall mean (a) BMS-270,394; and (b) should Pilot elect
to develop another compound covered by the Patents, either in substitution for
or in addition to BMS-270,394, such other compound.

         1.7 "Covered Product" shall mean any human pharmaceutical or animal
health product containing a Compound, whether or not such Compound is the sole
active ingredient in such product.

         1.8 "Early Clinical Studies," involving a Compound or any Covered
Product, shall mean, collectively, (a) the Phase I clinical studies therefor;
(b) the Proof-of-Principle Study for BMS 270,394; and (c) any other
Proof-of-Principle Study intended to establish proof-of-principle with respect
to an indication other than for the treatment of nodular cystic acne, each of
which studies shall, as a matter of its study protocol, be restricted at all
times to the accrual and inclusion of only male Adult patients.

         1.9 "Elected Country" shall have the meaning ascribed thereto in
Section 2.8.

         1.10 "Equity" shall mean, in the event Pilot has not completed its
initial public offering, shares of common or preferred stock of Pilot or other
security convertible into common stock of Pilot, or, in the event Pilot has
completed its initial public offering, shares of common stock of Pilot, or other
security convertible into common stock of Pilot. For the avoidance of doubt,
Equity may include options, warrants or other derivative securities instruments.

         1.11 "Fair Market Value" shall mean the U.S. dollar value of Equity
shares issued by Pilot measured using, in the event Pilot has not completed its
initial public offering, the applicable per Equity share price from Pilot's most
recent round of financing, or, in the event

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Pilot has completed its initial public offering, the arithmetic average of the
closing price of Pilot's publicly traded stock during of the ten trading days
prior to such issuance.

         1.12 "FDA" shall mean the United States Food and Drug Administration.

         1.13 "Generic Competition," on a calendar quarter-by-calendar quarter
and country-by-country basis, shall be deemed to exist if during any calendar
quarter and in the country in question the total unit sales of all Generic
Products during such calendar quarter in such country equal at least **% of the
unit sales of all Covered Products during such calendar quarter in such country
as determined by IMS or a reasonable equivalent firm, provided, that in no event
shall Generic Competition be deemed to exist in any Elected Country. If IMS or
the equivalent firm is not able to determine the unit sales of all Generic
Products, the Parties will work in good faith to determine if unit sales of all
Generic Products have reached **% of unit sales of all Covered Products. For the
avoidance of doubt, Pilot shall have the burden of establishing the existence of
Generic Competition.

         1.14 "Generic Product" shall mean any pharmaceutical product containing
an active ingredient that is (a) the same compound as BMS-270,394; or (b) should
Pilot elect to develop another Compound, either in substitution for or in
addition to BMS-270,394, such other Compound, which pharmaceutical product is
made and sold in direct competition with a Covered Product by any third party
that is neither an Affiliate nor a sublicensee of Pilot.

         1.15 "IND" shall mean Investigational New Drug Application filed with
the FDA providing for the clinical studies involving any Covered Product in the
United States or the counterpart document as filed with the Health Protection
Branch of Health and Welfare Canada.

         1.16 "NDA" shall mean a New Drug Application as filed with or approved
by the FDA or, when used in reference to Europe or Japan, the counterpart
pharmaceutical/medicinal product

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registration, and in the case of Europe, as filed or approved under the
centralized registration procedures of the European Union or the local
registration procedures of any country in the European Union and, in the case of
Japan, as filed with or approved by the Koseisho.

         1.17 "Net Sales" shall mean the aggregate arm's-length gross price that
Pilot, its Affiliates and, if applicable, its sublicensees to the trade charged
for sales of Covered Products in all countries during the relevant period, less
deductions for (i) rebates (including without limitation Medicaid rebates),
trade and cash discounts, credits, allowances, rebates or refunds incurred or
granted; (ii) bad debts actually incurred; and (iii) sales, use or excise taxes
and duties (including value added taxes), and freight and insurance, to the
extent included in the gross price charged.

         1.18     "Non-Exclusivity Credit," with respect to any calendar
                  quarter, shall mean: **% of (A x B / C), where

                  A =      The aggregate amount of worldwide royalties due for
                           such calendar quarter calculated as provided in
                           Section 2.2(a) prior to any deduction;

                  B =      The aggregate Net Sales of Covered Products in any
                           and all countries during such calendar quarter where
                           Generic Competition is deemed to exist during such
                           calendar quarter; and

                  C =      The aggregate Net Sales of Covered Products during
                           such calendar quarter in all countries worldwide.

                  Illustration. Assume in a given calendar year there are Net
Sales in countries X and Y (only) as follows:

<TABLE>
<CAPTION>

               Calendar quarter                 Net Sales in X               Net Sales in Y
               ----------------                 --------------               --------------
               <S>                              <C>                          <C>
                     1st                        $20,000,000                  $10,000,000
                     2nd                        $20,000,000                  $10,000,000
                     3rd                        $30,000,000                  $20,000,000
                     4th                        $30,000,000                  $20,000,000
</TABLE>

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The calendar quarter in question is the 4th quarter, during which Generic
Competition first came into existence in country Y.

The total royalties payable for the 4th quarter under Section 2.2(a) (i.e.,
before giving effect to any Generic Competition) would be:

                  $50,000,000 (which results in Net Sales for the full year of
$160,000,000); therefore, the calculation is (( $40,000,000 x **% ) +
($10,000,000 x **% )) = $**

The Non-Exclusivity Credit for the 4th quarter (using the formula in the
foregoing definition) is

                  **% x ($** x $20,000,000 / $50,000,000)
                  = $**

The total royalties payable as provided in Section 2.2(b) is therefore

                  $** - $** = $**

         1.19     "Payment Period" shall have the meaning ascribed thereto in
Section 3.1.

         1.20     "Patents" shall mean all existing patents and patent
applications covering BMS-270,394 or methods of manufacture or use thereof owned
or controlled by BMS as of date of this Agreement, including any extensions,
renewals, continuations, continuations-in-part, divisions, patents-of-addition
and reissues of any of them. Exhibit A hereto sets forth a list as of the date
hereof of Patents and pending patent applications upon which Patents may in due
course issue.

         1.21     "Phase III" clinical trial shall mean a large-scale clinical
trial involving a pharmaceutical product candidate intended primarily to
establish the efficacy of such product and customarily referred to in the
pharmaceutical industry as a "phase III" clinical trial.

         1.22     "Proof-of-Principle Study" shall mean, in the case of
BMS-270,394, the proposed phase IIa single-center, single-dose, double-blind,
randomized, placebo and ACCUTANE(R)-controlled clinical study intended to
evaluate the potential efficacy of oral BMS-270,394 for the

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treatment of nodular cystic acne or, in the case of any other Compound, a
comparable phase II clinical study intended to evaluate the potential efficacy
of such Compound for such indication.

         1.23     "Sublicensee Indemnity" shall have the meaning ascribed
thereto in Section 8.3.

                                    ARTICLE 2

                                 LICENSE, ETC.

         2.1      Grant of License to Pilot.

                  (a) BMS hereby grants to Pilot a worldwide, exclusive license,
with the right (but subject to the provisions of Article 6 and Section 8.3) to
grant sublicenses, under the Patents and the BMS Know-How to make, have made,
use, offer for sale and sell Covered Products.

                  (b) For so long as the license granted in Section 2.1(a) is in
effect, BMS shall not assert against Pilot or its Affiliates or its permitted
sublicensees, in connection with their exercise of the rights granted under such
license, when exercised in accordance with such license, any claim under any
existing patent owned or controlled by BMS as of date of this Agreement covering
BMS-270,394 or methods of manufacture or use, formulations, processes or
intermediates thereof. For the avoidance of doubt, the foregoing shall not
prohibit BMS from asserting against Pilot or its Affiliates or its sublicensees
(i) any claim arising from acts or omissions committed by them in violation of
such license and (ii) any claim under any patent owned or controlled by BMS
after the date of this Agreement which was not owned or controlled by BMS as of
the date of this Agreement, covering BMS-270,394 (including, without limitation,
improvements or alterations thereof) or methods of manufacture or use,
formulations, processes or intermediates thereof. Notwithstanding the foregoing,
in no event shall BMS assert any claim under any existing or future patent owned
or controlled by BMS that, by such assertion, would prevent Pilot from
exercising the grant of license provided in Section 2.1 (a) herein or the

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practice of the technology disclosed in the Patents or BMS Know-How.

         2.2      Royalties.

                  (a) In consideration of the license granted to Pilot pursuant
to Section 2.1, Pilot shall pay to BMS royalties on the Net Sales of Covered
Products, subject to Sections 2.8 and 4.4, based on the Applicable Royalty Rate.
For the avoidance of doubt, royalties in respect of a Covered Product shall be
payable once regardless of the number of claims in one or more Patents covering
such Covered Product.

                  (b) Notwithstanding the foregoing, with respect to any
calendar quarter during which Generic Competition exists in any country, the
amount of royalties payable by Pilot under Section 2.2(a) shall equal the amount
otherwise due minus the applicable Non-Exclusivity Credit.

         2.3      Term of Royalty. Sales of Covered Products on a
country-by-country basis will be includable in the determination of royalties
payable as provided in Section 2.2 or 2.8, as the case may be, until the later
to occur of (a) the 15th anniversary of the date of the first commercial sale of
any Covered Product in the country in question; and (b) if applicable, the date
as of which none of the acts of the making, using, offering for sale, or selling
such Covered Product would, without giving effect to the license hereunder,
infringe any Patent in such country. Upon the expiration of Pilot's obligation
to pay royalties pursuant to this Section 2.3, Pilot shall retain a paid-up,
perpetual non-exclusive license as otherwise provided in Section 2.1.

         2.4      License Fees. In addition to the royalties payable by Pilot as
provided in Sections 2.2 and 2.8, Pilot shall pay BMS the following license
fees:

                  (a) $** within 15 days following the date hereof;

                  (b) $** on or prior to the date that is six months from the
date hereof;

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                  (c) $** within 30 days of the completion (being last
patient/last visit) of the first Proof-of-Principle Study ;

                  (d) $** within 60 days of the completion (being last
patient/last visit) of the first Phase III clinical program for any Covered
Product for any indication;

                  (e) $** upon the filing of the first NDA with the FDA for any
Covered Product;

                  (f) $** upon the filing of the first NDA for any Covered
Product in Europe;

                  (g) $** upon the filing of the first NDA for any Covered
Product in Japan;

                  (h) $** upon the first approval of an NDA by the FDA for any
Covered Product;

                  (i) $** upon the first approval of an NDA for any Covered
Product in Europe; and

                  (j) $** upon the first approval of an NDA for any Covered

Product in Japan. All such license fees are non-refundable, nor shall they be
creditable against current or future earned royalties otherwise payable pursuant
to Section 2.2 or 2.8. For the avoidance of doubt, the payments set forth in
Sections 2.4(a)-(j) shall each be payable one time only.

         2.5      Pilot's Obligations as Licensee.

                  (a) Pilot shall, directly or indirectly through Affiliates
and/or sublicensees, use commercially reasonable efforts to develop and market
one or more Covered Products and to obtain FDA approval of such Covered
Product(s) and release and approval from other governmental agencies in the
United States and foreign countries necessary to obtain approval to market and
sell such Covered Products in such country. Without prejudice to Pilot's
obligations to develop and commercialize Covered Products hereunder, Pilot shall
in any event promptly

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notify BMS in writing of any determination on its part not to commence, or to
discontinue, the development or commercialization of BMS-270,394 or any other
Compound.

                  (b) Without limiting the generality of Section 2.5(a), for the
purpose of determining whether to embark on the Proof-of-Principle Study for
BMS-270,394, Pilot agrees to conduct the studies on BMS-270,394 as described on
Exhibit B hereto.

         2.6      BMS' Obligations as Licensor. BMS shall promptly upon Pilot's
reasonable request transfer to Pilot the BMS Know-How, it being understood that
all the BMS Know-How will be transferred by BMS on an "as is" basis and
accordingly, among other things, BMS shall not be required to complete any
abandoned or terminated preclinical study or investigation or the analysis
thereof, nor shall BMS be required to prepare or complete reports, summaries or
other documents reflecting the results of any study or investigation, whether or
not previously completed.

         2.7      Intermediates and Drug Supplies.

                  (a) Exhibit C hereto sets forth the available inventories of
BMS-270,394 and certain synthetic intermediates therefor. BMS agrees promptly to
furnish the listed materials to Pilot in the quantities, at the prices and
otherwise in accordance with the terms on Exhibit C hereto.

                  (B) ALL MATERIALS ARE FURNISHED BY BMS UNDER THIS SECTION 2.7
ON AN "AS IS" BASIS. BMS MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTY OF ANY
KIND, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTY OF
MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR USE OR PURPOSE.

         2.8      Alternative Royalty Scheme. On a country-by-country basis,
Pilot may elect to

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pay, in lieu of the royalties otherwise payable under Section
2.2(a), consideration for the license under Section 2.1 as provided in this
Section 2.8 (each country subject to such election, an "Elected Country"),
provided that (i) Covered Products are sold in the country in question only by a
sublicensee of Pilot (and by neither Pilot nor its Affiliates); (ii) within 60
days of the signing of the related definitive sublicensing agreement with such
sublicensee, Pilot gives BMS written notice of such election, accompanied by a
copy of such sublicensing agreement; (iii) any such election shall be
irrevocable unless the sublicensing agreement is terminated; and (iv) any such
election shall cover all (and not fewer than all) countries subject to such
sublicensing agreement. With respect to each Elected Country for any calendar
quarter:

                  (a) Pilot shall be entitled to deduct from the aggregate
amount of royalties otherwise payable by Pilot under Section 2.2(a) for such
calendar quarter an amount equal to

                  ( D x E / F ), where

                  D = The aggregate amount of worldwide royalties due for such
calendar quarter calculated as provided in Section 2.2(a) prior to any
deductions;

                  E = The aggregate Net Sales of Covered Products in such
Elected Country during such calendar quarter; and

                  F = The aggregate Net Sales of Covered Products during such
calendar quarter in all countries worldwide; and

                  (b) Pilot shall instead pay over to BMS **% of all
compensation and consideration (whether in the form of signing fee, license fee,
milestone payment, royalty or otherwise, but excluding payments for research and
development support for Covered Products that can be substantiated or for Equity
issued by Pilot at or above Fair Market Value) due Pilot for the grant of the
sublicense under the Patents to make, use, offer for sale or sell Covered

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Products.

                  Illustration. Assume in a given calendar year there are Net
Sales in countries X and Y (only) as follows:

<TABLE>
<CAPTION>

                               Calendar quarter            Net Sales in X               Net Sales in Y
                               ----------------            --------------               --------------
                               <S>                         <C>                          <C>
                                        1st                $10,000,000                  $5,000,000
                                        2nd                $10,000,000                  $5,000,000
                                        3rd                $15,000,000                  $10,000,000
                                        4th                $15,000,000                  $10,000,000
</TABLE>

Country X is not, but country Y is, an Elected Country.

1st Quarter. The total royalties payable for the 1st quarter under Section
2.2(a) (i.e., before giving effect to the deduction as provided in Section
2.8(a)) would be:

                  $15,000,000 x **% = $**

The deduction under Section 2.8(a) is

                  ( D x E / F ), which equals

                  $** x ( $5,000,000 / ( $10,000,000 + $5,000,000 ) )
              =   $**

Therefore, as provided in Section 2.8(a), in respect of country X (not an
Elected Country) Pilot would pay royalties equal to

                  $** - $**
              =   $**

In respect of country Y (an Elected Country), as provided in Section 2.8(b),
Pilot would pay over to BMS **% of the royalties actually received from its
sublicensee during the 1st quarter.

4th Quarter. The total royalties payable for the 4th quarter under Section
2.2(a) (i.e., before giving effect to the deduction as provided in Section
2.8(a)) would be:

                  $25,000,000 x **% = $**

The deduction under Section 2.8(a) is

                  ( D x E / F ), which equals

                  $** x ( $10,000,000 / ( $15,000,000 + $10,000,000 ) )
              =   $**

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Therefore, as provided in Section 2.8(a), in respect of country X (not an
Elected Country) Pilot would pay royalties equal to

                  $** - $**
               =  $**

In respect of country Y (an Elected Country), as provided in Section 2.8(b),
Pilot would pay over to BMS **% of the royalties actually received from its
sublicensee during the 4th quarter.

                                    ARTICLE 3

                              PAYMENTS AND REPORTS

          3.1 Payments. All payments due by Pilot under this Agreement
shall accrue and be paid to BMS in the United States in U.S. dollars, quarterly
within 75 calendar days following the end of each calendar quarter (each
calendar quarter being a period of three consecutive calendar months commencing
January, April, July or October, as the case may be), (each such time period, a
"Payment Period"). Each such payment shall be accompanied by a statement showing
the amounts of gross sales and Net Sales and the number of units of Covered
Products sold by Pilot, its Affiliates and, if applicable, its sublicensees
during such quarter (on a country-by-country basis), the amount of royalties due
on such Net Sales, and the amount deductions taken for Non-Exclusivity Credits
and for Elected Countries pursuant to Section 2.8, including the calculations
and information with which such calculations were undertaken. Any payments or
portions thereof due hereunder which are not paid during the applicable Payment
Period shall bear interest at a rate equal to the lesser of the prime rate as
published in The Wall Street Journal, Eastern Edition, on the first business day
immediately following the end of such Payment Period, plus four (4) percentage
points, and the maximum rate permitted by law, calculated on the number of days
such payment is delinquent after the end of such Payment Period, compounded
monthly.

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               3.2 Mode of Payment. Amounts due from Pilot to BMS in respect of
sales outside of the United States shall be converted to U.S. dollars at an
exchange rate equal to the arithmetic average of the applicable exchange rates
reported in The Wall Street Journal, Eastern Edition for the currency of the
country in question on each of the last 10 business days of the calendar quarter
in question.
               3.3 Records Retention. Pilot shall, and shall, if applicable,
cause its Affiliates and sublicensees to, keep complete and accurate records
pertaining to the manufacture, use and sale of Covered Products in sufficient
detail to permit BMS to audit and confirm the accuracy of calculations of
payments due to BMS hereunder. Such records shall be retained by the party in
question for at least three years or for such longer period if and as required
by law.
               3.4 Audit Request. At the request of BMS, Pilot shall, and shall,
if applicable, cause its Affiliates and sublicensees to, permit BMS or an
independent certified public accountant appointed by BMS and reasonably
acceptable to Pilot, at reasonable times and upon reasonable notice, to examine
such records as may be necessary to: (i) determine, with respect to any calendar
year ending not more than three years prior to BMS' request, the correctness of
any report or payment made under this Agreement; or (ii) obtain information as
to the amount payable for any such calendar year in the case of failure on the
part of Pilot to report or pay pursuant to this Agreement. The results of any
such audit shall be promptly made available to Pilot. BMS shall not be entitled
to exercise its audit rights under this Section 3.4 more than once in any 12
consecutive month period.

               3.5 Cost of Audit. BMS shall bear the full cost and expense of
the performance of any such audit undertaken pursuant to Section 3.4, unless
such audit discloses that the amount due exceeds the amount paid by more than
5%, in which case Pilot shall bear the full cost and

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expense of the performance of such audit.

         3.6 Binding Results. The determination by an independent certified
public accountant pursuant to Section 3.4 as to the amount due and payable by
Pilot hereunder shall be conclusive and binding upon both parties.

                                    ARTICLE 4

                                 PATENT MATTERS

         4.1 Prosecution and Maintenance. Pilot shall, at its sole expense, use
commercially reasonable efforts to prosecute all patent applications upon which
Patents may in due course issue and maintain all issued Patents using counsel of
its choice. The countries in which Pilot agrees to prosecute patent applications
and maintain Patents are those countries listed on Exhibit A hereto. Pilot may,
at it sole expense, elect to prosecute patent applications and maintain Patents
in any other countries. Pilot shall provide BMS with all material information
and copies of all material documentation pertaining to the status of such patent
applications and issued Patents. Pilot shall provide BMS with complete and
correct copies of all filings relating to patent applications included in
Patents prior to their submission to any governmental agency to give BMS a
reasonable amount of time, not to exceed thirty (30) days, to review and provide
comment upon such filings prior to their submission. Pilot shall take into
consideration any comments made by BMS regarding such filings. BMS shall provide
any and all reasonable cooperation to Pilot, including but not limited to
execution of declarations and other formal papers, to enable Pilot to prosecute
and maintain Patents; provided that Pilot shall reimburse BMS for reasonable
out-of-pocket expenses incurred by BMS as a direct result of providing such
cooperation.

         4.2 Patent Term Extension. Either party shall be entitled to apply for
an extension of

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the term of any Patent if appropriate under the Drug Price Competition and
Patent Term Restoration Act of 1984 or comparable laws of foreign countries. If
a party decides to apply for said extension, it shall notify the other party,
who shall cooperate by supplying all documents in its possession and signing all
papers which may be necessary to apply for such extension. The party applying
for said extension shall not be liable to the other party for any failure to
obtain said extension. The party applying for such an extension will pay the
costs and expenses it incurs in connection with such application.

         4.3 Patent Enforcement. Pilot, together with its Affiliates and
sublicensees, shall have the first right, but not the obligation, to institute
patent infringement actions against third parties pertaining to any Patent and
BMS as patent owner agrees to be added as a nominally named party to any such
suit to the extent legally necessary for and only for Pilot to institute or
maintain the suit. Only if (a) Pilot determines not to institute any
infringement proceeding against such an offending third party and so notifies
BMS in writing or (b) Pilot fails to do so within 180 days following BMS'
request to do so shall BMS have the right, but not the obligation, to institute
such an action. The costs and expenses of any such action (including fees of
attorneys and other professionals) shall be borne by the party instituting the
action, or, if the parties elect jointly to institute and pursue such action,
such costs and expenses shall be borne by the parties in such proportions as
they may agree in writing. Each party shall execute all necessary and proper
documents and take such actions as shall be reasonable and appropriate to allow
the other party to institute and pursue such infringement actions. Any award
paid by a third party as a result of such an infringement action (whether by way
of settlement or otherwise) shall be paid to the party who instituted and
pursued such action, or, if both parties instituted and pursued such action,
such award shall be first used to reimburse the parties for their respective

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costs and expenses incurred in such action and then allocated between the
parties in proportion to their respective economic losses attributable to the
infringement, such economic losses being (a) in the case of Pilot and its
Affiliates and sublicensees, lost profits reasonably attributable to the lost
sales, and (b) in the case of BMS, lost royalty income.

         4.4 Third Party Patents. In the event that, based on the legal opinion
of a reputable patent law firm reasonably acceptable to BMS, the making, using,
offering for sale, or sale of any Covered Product (other than technology that,
while useful, is not strictly necessary for the making, using, offering for
sale, or sale of such Covered Products, such as a delivery system for such
Covered Products), BMS Know-How, or the invention claimed in any Patent, in and
of itself, would infringe the issued patent of any third party in any country
and, for that reason, Pilot obtains a license from and pay royalties or other
fees to such third party in order to make, use, offer for sale or sell a Covered
Product in such country without infringing on such issued patent, then Pilot may
reduce the royalties on Net Sales owed to BMS under Sections 2.2 and 2.8) with
respect to sales of such Covered Product in such country during a calendar
quarter, by an amount equal to the lesser of (a) 50% of the amount of such
royalties or other fees actually paid to the third party on sales in such
country within the same calendar quarter or (ii) 50% of the amount of the
royalties originally owed to BMS under Sections 2.2 or 2.8 (calculated without
regard to this Section 4.4).

         4.5 BMS' Right to Participate in Certain Actions. BMS shall have the
right, but not the obligation, to participate at its own cost and expense in any
suit or other proceeding wherein the validity or enforceability of any Patent is
being invoked in the context of a claim or defense.

         4.6 Warranties.

             (a) BMS hereby represents that as of the date hereof it is not
aware, without,

                                       17
<PAGE>
however, having conducted any patent search or other investigation, that: (i)
any issued Patent is either invalid or unenforceable; (ii) the manufacture, use,
offering for sale or sale of any product containing BMS-270,394, as heretofore
carried out or proposed to be carried out by BMS, would infringe the patent or
other intellectual property rights of any third party; and (iii) any third party
is infringing any Patent.

             (b) Other than as set forth in Section 4.6(a) or Section 10.2(a),
BMS hereby expressly disclaims any representation or warranty as to the
validity or enforceability of any Patent, the non-infringement of any third
party patent or other intellectual property right or the prospects or
likelihood of development or commercial success of any Compound or any Covered
Product.

                                   ARTICLE 5

                                 INDEMNIFICATION

         5.1 Indemnification.

             (a) Pilot shall defend and indemnify BMS and its Affiliates, and
their directors, officers and employees, and hold each of them harmless, from
and against any and all claims, suits or demands for liability, damages, costs
and expenses, including the reasonable costs and expenses of attorneys and other
professionals and court costs (all of the foregoing, collectively, "Claims"),
(i) resulting from product recall, personal injury, product liability or
property damage relating to or arising from the making, use, offering for sale
and/or sale of any Compound and/or any Covered Product by Pilot or any of its
Affiliates or sublicensees or (ii) attributable to a breach of Pilot's
representations and warranties herein, except in each case to the extent that
the same is attributable to the intentional misconduct or negligence of the
party otherwise entitled to indemnification.

                                       18
<PAGE>
             (b) BMS shall defend and indemnify Pilot and its Affiliates, and
their directors, officers and employees, and hold each of them harmless, from
and against any and all Claims attributable to a breach of BMS' representations
and warranties herein, except to the extent that the same is attributable to the
intentional misconduct or negligence of the party otherwise entitled to
indemnification.

         5.2 Notices. A party seeking indemnification under Section 5.1 shall:
(a) promptly inform the indemnifying party of any Claim threatened or filed; (b)
permit the indemnifying party to assume direction and control of the defense of
Claims resulting therefrom (including the right to settle at the indemnifying
party's sole discretion as long as such settlement does not result in any
obligation or liability on the part of the party seeking indemnification or any
other party entitled to indemnification hereunder); and (c) at its own cost and
expense, cooperate fully as reasonably requested in the defense of the Claims.

                                   ARTICLE 6

                               CERTAIN BMS RIGHTS

         6.1 Offer to BMS. With respect to each Compound, promptly upon the
completion of the Proof-of-Principle Study therefor, Pilot shall offer to BMS a
worldwide, exclusive license to such Compound in accordance with the provisions
of this Article 6. Pilot shall promptly furnish BMS with a full written report
of the results from such study, full written reports of all theretofore
completed preclinical and clinical studies and such other information and data
as BMS may reasonably request, together with proposed financial terms for such
license (which terms shall be commercially reasonable). BMS shall then have 60
days to determine whether it wishes to enter into negotiations with Pilot to
take a license from Pilot and otherwise reacquire all rights to such Compound
from Pilot. In the absence of a written notice from BMS in the

                                       19
<PAGE>
affirmative within such 60-day period, BMS shall be deemed to have declined the
offer from Pilot. If BMS by written notice to Pilot declines, or is deemed to
have declined, Pilot's offer, Pilot shall forthwith be free to enter into
sublicensing agreements under the license hereunder with third parties. Pilot
may also enter into sublicensing agreements during such 60-day period, but only
on the condition that each such sublicensing agreement be expressly subject to
BMS' rights under this Article 6. No such conditional sublicensing agreement
with a third party shall toll or affect in any way the 60-day period in which
BMS may exercise its rights pursuant to this Section 6.1. For the avoidance of
doubt, all sublicenses granted pursuant to this Section 6 are subject to the
requirements set forth in Section 8.3.

         6.2 Negotiation. If BMS accepts Pilot's offer as contemplated by
Section 6.1 by written notice to Pilot within the said 60-day period, the
parties shall negotiate in good faith with a view to entering expeditiously
appropriate legal documentation setting forth the mutually agreed terms and
conditions for the implementation of the said worldwide, exclusive license.
Should the parties fail to reach agreement within 90 days from the date of BMS'
notice accepting Pilot's offer, then, upon the expiration of the 90-day period
(or, if earlier, upon the date that BMS delivers written notice to Pilot that it
no longer desires to pursue the license, in which case the negotiation period
shall be deemed expired), Pilot shall forthwith be free to enter into
sublicensing agreements under the license hereunder with third parties, subject,
however, to the provisions of Section 6.3.

         6.3 Residual Right. Within six months following the expiration of the
negotiation period under Section 6.2 without the parties reaching an agreement
with respect to a Compound, Pilot shall not enter or commit to enter into any
transaction or relationship relating to such Compound with any third party on
terms (when considered as a whole) less favorable to Pilot

                                       20
<PAGE>
 then the terms last offered by Pilot to BMS during such negotiation
period, without first reoffering such less favorable terms to BMS as provided in
this Section 6.3. In any such case, Pilot shall disclose to BMS in writing the
material terms and conditions in question. Only if BMS does not accept
substantially the same less favorable to Pilot terms and conditions (when
considered as a whole) within 30 days following such written disclosure shall
Pilot have the right to enter into such transaction or relationship with such
third party on such less favorable to Pilot terms and conditions. For the
avoidance of doubt, in no event shall this Section 6.3 be construed to limit,
restrict or affect in any way Pilot's ability or right to offer terms to any
such third party that, when considered as a whole, are more favorable to Pilot
than those offered to BMS or to enter into any agreement or transaction with
such third parties on such more favorable terms.

         6.4 No Unconditional Sublicensing. Until such time as Pilot becomes
free to enter into sublicensing agreements under the license hereunder with
third parties as provided in Section 6.1 or 6.2, as the case may be, Pilot may
enter into any agreement or understanding relating to, or consummate, any
sublicensing of Pilot's rights hereunder, or otherwise licensing Pilot's rights
to or in a Compound, to any third party, but only on the condition that each
such agreement, understanding, sublicensing or licensing be expressly subject to
BMS' rights under this Article 6. For the avoidance of doubt, nothing in this
Article 6 shall be construed as precluding Pilot at any time from soliciting,
offering or engaging in any discussion or negotiation, or entering into any
non-binding letter of intent or conditional sublicensing agreement, with any
third party relating to the sublicensing of Pilot's rights hereunder, or
otherwise licensing Pilot's rights to or in a Compound.

                                       21
<PAGE>

                                   ARTICLE 7

                                CONFIDENTIALITY

         7.1 Confidentiality; Exceptions. Except to the extent in connection
with this Agreement or otherwise agreed by the parties in writing, the parties
agree that, at all times during the five (5) year period following receipt, the
receiving party shall keep completely confidential, shall not publish or
otherwise disclose and shall not use directly or indirectly for any purpose any
information furnished to it by the other party pursuant to this Agreement,
including, without limitation, the BMS Know-How, except to the extent that it
can be established by the receiving party by competent proof that such
information:

             (a) was already known to the receiving party, other than under an
obligation of confidentiality, at the time of disclosure by the other party;

             (b) was generally available to the public or otherwise part of the
public domain at the time of its disclosure to the receiving party;

             (c) became generally available to the public or otherwise part of
the public domain after its disclosure, other than through any act or omission
of the receiving party in breach of this Agreement; or

             (d) was disclosed to the receiving party, other than under an
obligation of confidentiality, by a third party who had no obligation to the
disclosing party not to disclose such information to others.

Each party may disclose the other's information to the extent such disclosure is
reasonably necessary in filing or prosecuting patent applications, pursuing or
defending litigation, or complying with applicable governmental regulations,
provided that if a party intends to make any such disclosure, it shall, to the
extent reasonably practicable, give reasonable advance written notice to the
other party of such disclosure. Nothing in this Section 7.1, however, shall be
construed to preclude Pilot from disclosing such information to such third
parties as are

                                       22
<PAGE>
necessary in connection with the development and commercialization of Compounds
and Covered Products as contemplated by this Agreement, including, without
limitation, financing, sublicensing, co-development, co-marketing and
co-promotion or similar transactions in connection therewith, provided that
Pilot shall in each case obtain from the proposed receiving party a written
confidentiality undertaking containing confidentiality obligations no less
onerous than those set forth in this Section 7.1; provided, however that in no
event shall this Section 7 bar or prevent Pilot from distributing, offering for
sale, and/or selling a Covered Product.

         7.2 Publication. Without prejudice to any claim for authorship that BMS
or its employees or agents may have, BMS shall not unreasonably withhold consent
to Pilot's request for publication of data and information that constitute BMS'
Know-How in established scientific and medical journals. Nothing herein shall be
construed to limit, restrict or otherwise affect Pilot's ability and right to
publish any data or other information regarding BMS-270,394 and any Covered
Product that is developed by Pilot after the date hereof or was otherwise
obtained after the date hereof from a source other than BMS; provided, that such
data or information does not include any BMS Know-How without the consent of
BMS.

                                    ARTICLE 8

                              CERTAIN RESTRICTIONS

         8.1 Drug Safety-Related Concerns. BMS-270,394 is an experimental
material and accordingly its safety profile and many properties remain unknown.
More specifically, Pilot expressly recognizes the teratogenic and other severe
toxicities, and potential neurological effects, associated with this class of
compounds and agrees to implement appropriate measures and procedures for the
handling, storage and disposition of BMS-270,394 and all Covered Products.

                                       23
<PAGE>
         8.2 Early Clinical Studies.

             (a) In order to minimize undue risks associated with exposure to
any Compound or any Covered Product, Pilot shall not include, and shall not
permit the inclusion of, any human subject other than male Adults in any Early
Clinical Study. Pilot shall conduct, and shall cause to be conducted, any and
all Early Clinical Studies only in the United States and Canada under its own
(and only under its own) IND.

             (b) Until such time as a Sublicensee Indemnity has been executed
and delivered to BMS, except as provided in Section 8.2(c), Pilot shall: (i) not
conduct, and not permit the conduct of, any clinical study involving any
Compound or any Covered Product other than the Early Clinical Studies; (ii) not
otherwise administer, and not permit the administration of, any Compound or any
Covered Product to any human subject other than male Adults, whether or not in a
formal clinical study setting; and (iii) not furnish, and not permit the
furnishing of, any quantity of any Compound or any Covered Product (whether or
not obtained from BMS hereunder) to any third party for use in any clinical
study, commercial sale or otherwise for administration to any human subject.

             (c) With respect to any Compound or any Covered Product, following
(and only following) the completion of the related Proof-of-Principle Study, and
provided that the results of such study, as a matter of both efficacy and
safety, reasonably warrants the continued clinical study of the Covered Product
in question for the indication in question, Pilot or its permitted licensees
under Section 8.3(b) may conduct one or more clinical studies on such Covered
Product for such indication, provided that: (i) each such study shall, as a
matter of its study protocol, be restricted at all times to the accrual and
inclusion of only male Adult patients; (ii) Pilot shall have furnished BMS with
at least 10 business days' advance written notice of the

                                       24
<PAGE>
prospective commencement of each such study, which notice shall include a
statement to the effect that such study complies with the requirement of the
foregoing clause (i); and (iii) Pilot shall, if so requested by BMS, promptly
provide BMS with a copy of the related study protocol.

             (d) Any breach by Pilot of any of the covenants in this Section 8.2
or in Section 8.3 shall, without more, be deemed to be a material breach of this
Agreement entitling BMS to terminate this Agreement pursuant to Section 9.2.

         8.3 Indemnity. Pilot agrees, prior to (a) the commencement of any
clinical study involving any Compound or any Covered Product, other than the
Early Clinical Studies and any studies permitted under Section 8.2(c); and (b)
the sublicensing to any third party of any rights granted by BMS under this
Agreement other than for the Early Clinical Studies and any studies permitted
under Section 8.2(c), to cause to be duly executed and delivered to BMS a
Sublicensee Indemnity. For purposes of this Agreement, "Sublicensee Indemnity"
shall mean an agreement in the form of Exhibit D hereto, with only such changes
as are necessary to identify the party executing such agreement, the date of
execution and are contemplated by the next succeeding sentence, in favor of BMS
executed and delivered (by a corporate officer and otherwise in a manner
reasonably satisfactory to BMS) by the ultimate parent company of any of the
companies listed on Exhibit E attached hereto or any Affiliates of such
companies or any other corporation or other business entity, provided such
Affiliates, other corporations or business entities are primarily in the
business of developing and commercializing branded (as opposed to generic)
prescription pharmaceutical products and (x) had, during its most recently
completed fiscal year, no less than $** of sales revenues; or (y) as of the end
of its most recently completed fiscal year, had net assets of no less than $**
whereby, in the case of (x) and (y) such amounts are as reported in its audited
financial statements. In the event an Affiliate of a company desires to

                                       25
<PAGE>
enter into a sublicense with Pilot pursuant to which a Sublicensee Indemnity is
required under the terms of this Agreement but such Affiliate does not qualify
under the either of the financial conditions set forth in (x) and (y) above, but
an Affiliate of such Affiliate does so qualify, then non-qualifying Affiliate
may enter into such sublicense only after it and the qualifying Affiliate each
execute and deliver to BMS a Sublicensee Indemnity. BMS agrees to consider in
good faith any change to the form of the Sublicensee Indemnity requested by the
proposed sublicensee and not to reject any such request unreasonably; it being
understood, however, that BMS shall be entitled to reject any request if BMS has
any reason, acting in its own interest, to do so and, in doing so, BMS, so long
as it is acting reasonably, shall not be required to balance its own reason
against the reason or reasons for making the proposed change or changes.

                                   ARTICLE 9

                               TERM; TERMINATION

         9.1 Term of Agreement. Unless sooner terminated as provided herein,
this Agreement shall commence as of the date first above written and shall
expire in its entirety at such time as Pilot shall have no more obligation to
pay any amounts to BMS as provided in Article 2, assuming, for this purpose,
that there are at all times Net Sales of a Covered Product.

         9.2 Breach. Failure by either party to comply with any of the material
obligations contained in this Agreement shall entitle the other party to give to
the party in default a written notice specifying the nature of the default and
requiring it to cure such default. If such default is not cured within 60 days
after the receipt of such notice, the notifying party shall be entitled, without
prejudice to any of its rights conferred on it by this Agreement, in addition to
any other remedies available to it by law or in equity, to terminate this
Agreement by giving a second written notice, such termination to take effect 30
days after receipt of such second notice;

                                       26
<PAGE>
provided, however, that, in the case of a termination as the result of Pilot's
breach under Sections 8.2 or 8.3, there shall be no cure period and BMS shall be
entitled to terminate this Agreement immediately (without the 30-day waiting
period) upon written notice to Pilot. The right of either party to terminate
this Agreement, as hereinabove provided, shall not be affected in any way by its
waiver or failure to take action with respect to any previous default.

         9.3 Termination by BMS. Without limiting the generality of Section 9.2,
in addition to the provisions of Section 8.2(c), each of the following shall
constitute sufficient cause for termination of this Agreement by BMS, subject to
all of the cure periods and notice procedures set forth in Section 9.2: (a)
Pilot shall fail to pay any license fee or royalty when due as provided in
Section 2.4, 2.2 or 2.8, as applicable; (b) Pilot shall fail to perform its
obligations under Section 2.5; (c) Pilot shall fail to start a
Proof-of-Principle Study within a reasonable amount of time following the
completion of the studies set forth on Exhibit B hereto; (d) Pilot shall fail to
continue to use commercially reasonable efforts to pursue the Proof-of-Principle
Study once started; and (e) Pilot shall determine not to commence or to
discontinue the development or commercialization of all Compounds and all
Covered Products.

         9.4 Termination by Pilot. After (and only after) Pilot's payment of the
two license fees under Sections 2.4(a) and (b), Pilot shall have the right to
terminate this Agreement at any time and for any reason by giving a written
notice to BMS. Such termination shall be effective 30 days from the date such
notice is given.

         9.5 Insolvency or Bankruptcy. Either party may, in addition to any
other remedies available to it by law or in equity, terminate this Agreement by
written notice to the other party in the event the other party shall have become
insolvent or bankrupt, or shall have made an assignment for the benefit of its
creditors, or there shall have been appointed a trustee or receiver

                                       27
<PAGE>
of the other party or for all or a substantial part of its property, or any case
or proceeding shall have been commenced or other action taken by or against the
other party in bankruptcy or seeking reorganization, liquidation, dissolution,
winding-up, arrangement, composition or readjustment of its debts or any other
relief under any bankruptcy, insolvency, reorganization or other similar act or
law of any jurisdiction now or hereafter in effect, or there shall have been
issued a warrant of attachment, execution, distraint or similar process against
any substantial part of the property of the other party; and, in any such case,
the event shall have continued for 60 days undismissed, unbonded and
undischarged.

         9.6 Continuation of Sublicenses. Except as otherwise expressly provided
in this Agreement, upon any termination of this Agreement, all sublicenses
granted by Pilot under this Agreement shall terminate simultaneously. Upon any
termination of this Agreement for any reason, except a termination by BMS due to
a breach of this Agreement by Pilot where such breach has been contributed to by
any act or omission by a sublicensee, any sublicensee (except such a
contributing sublicensee) may assume all of Pilot's obligations under this
Agreement (including, without limitation all past amounts due and breaches
requiring cure) and, upon such assumption, such sublicensee's rights under this
Agreement shall be limited to the territory of such sublicensee's sublicense
grant from Pilot. If such sublicensee desires to assume such obligations of
Pilot, such sublicensee must execute and deliver a copy of this Agreement
(reflecting any limit on sublicensee's territory) to BMS within 30 days of
receiving notice of such termination from BMS.

         9.7 Right to Sell Inventory. Following any termination of this
Agreement, Pilot and its Affiliates and, if applicable, sublicensees shall
continue to have the right for 12 months following termination to dispose of all
Covered Products then on hand, and royalties shall be

                                       28
<PAGE>
paid to BMS in respect of to such Covered Products as though this Agreement had
not been so terminated; provided, such disposal of Covered Products shall not be
in derogation of the safety concerns set forth in Section 8.1, in breach of
Section 8.1, or in breach of Section 8.2(a), if applicable.

         9.8 BMS Know-How; Drug Supplies. Upon any termination of this
Agreement, except to the extent required to dispose of Covered Products as
permitted by Section 9.7, Pilot shall, upon request of BMS, promptly return to
BMS all BMS Know-How and any and all unused drug supplies theretofore obtained
from BMS under Section 2.7. Except to the extent required to dispose of Covered
Products as permitted by Section 9.7, Pilot shall in any event cease to have any
right to use any BMS Know-How or such drug supplies regardless of whether BMS
has so requested.

         9.9 Disclosure on Termination. Upon any termination of this Agreement
(except upon termination by Pilot pursuant to Section 9.2 following a breach of
this Agreement by BMS), Pilot shall promptly, upon request by BMS, disclose to
BMS all data, information and know-how relating to the Covered Products
developed during the term of the Agreement and transfer and assign to BMS all
NDAs and other product registrations worldwide, if any, together with any and
all trademarks worldwide, specifically and only for any and all Covered Products
then held by Pilot or its Affiliates. BMS shall be free to exploit the same
commercially and otherwise.

         9.10 Surviving Rights. Any termination of this Agreement shall not
terminate Pilot's obligation to pay any amount which shall have accrued under
this Agreement, nor shall the expiration or any termination of this Agreement
for any reason otherwise be with prejudice to any rights which shall have
accrued to the benefit of either party prior to expiration or

                                       29
<PAGE>
termination. The parties' rights and obligations under Articles 3, 4, 5 and 7
shall survive the expiration or any termination of this Agreement. Except as
expressly set forth in this Section 9.10, all rights and obligations of the
parties hereunder shall terminate upon termination of this Agreement.

                                   ARTICLE 10

                            MISCELLANEOUS PROVISIONS

         10.1 Assignment. Except as otherwise provided herein, neither this
Agreement nor any interest hereunder shall be assignable by either party without
the prior written consent of the other party; provided, that in the case of an
assignment by Pilot to an Affiliate, such consent shall not be unreasonably
withheld, and provided further that an assignment may be made to the purchaser
of a party or to a purchaser of substantially all of the assets of a party in
the relevant business area involved without such prior written consent provided,
however, that such purchaser expressly agrees to be bound by the terms of this
Agreement. This Agreement shall be binding upon the successors and permitted
assigns of the parties. Any assignment not in accordance with this Section 10.1
shall be null and void.

         10.2 Representation and Warranties. (a) BMS hereby represents and
warrants that: (i) it is free to enter into this Agreement and has all requisite
corporate authorization to do so; (ii) it owns the entire right, title and
interest in and to the Patents and the BMS Know-How that it purports to license
or transfer to Pilot under this Agreement, free and clear of all liens, claims
or other encumbrances; (iii) in performing this Agreement it will not violate
any other agreement to which it is a party; and (iv) U.S. Patent No. 5,624,957
is properly enabled under 35 U.S.C.ss.112, first paragraph and that BMS has
filed an affidavit from Makonen Belema, a co-inventor of pending U.S. Patent

                                       30
<PAGE>
Application Serial No. 09/401,356, in pending U.S. Patent Application Serial No.
09/401,356 averring that U.S. Patent No. 5,624,957 has been properly enabled so
as to permit one skilled in the art to practice the claimed invention,
particularly making enantiomers using methods disclosed in U.S. Patent No.
5,624,957, under 35 U.S.C.ss.112.

             (b) Pilot hereby represents and warrants that: (i) it is free to
enter into this Agreement and has all requisite corporate authorization to do
so; and (ii) in performing this Agreement it will not violate any other
agreement to which it is a party.

             (c) This Section 10.2 shall survive the execution, expiration or
termination of this Agreement.

         10.3 Force Majeure. Neither party shall be liable to the other party
for loss or damages or shall have any right to terminate this Agreement for any
default or delay attributable to any act of God, flood, fire, explosion, strike,
lockout, labor dispute, shortage of raw materials, casualty or accident, war,
revolution, civil commotion, act of public enemies, blockage or embargo,
injunction, law, order, proclamation, regulation, ordinance, demand or
requirement of any government or subdivisions, authority or representative of
any such government, or any other cause beyond the reasonable control of such
party, if the party affected shall give prompt notice of any such cause to the
other party. The party giving such notice shall thereupon be excused from such
of its obligations hereunder as it is thereby disabled from performing for so
long as it is so disabled and for 30 days thereafter. Notwithstanding the
foregoing, nothing in this Section 10.3 shall excuse or suspend the obligation
to make any payment due hereunder in the manner and at the time provided.

         10.4 Public Announcements; Use of Name. Except as required by law,
neither party shall make any public announcement concerning this Agreement or
the subject matter hereof

                                       31
<PAGE>
without the prior written consent of the other party (which consent shall not be
unreasonably withheld). In the event of a legally required public announcement,
the party making such announcement shall provide the other party with a copy of
the proposed text, subject to such other party's reasonable comments, prior to
such announcement. Except as otherwise provided herein, neither party shall have
any right to use in any manner the name or other designation of the other party
or any of its Affiliates, or any other trade name or trademark of any of them,
for any purpose.

         10.5 Notices. All notices and other communications hereunder shall be
in writing and shall be deemed given when delivered personally, two days after
mailed by registered or certified mail (return receipt requested), postage
prepaid, or one day after sent by overnight courier service to the parties at
the following addresses (or at such other address for a party as shall be
specified by like notice; provided that notices of a change of address shall be
effective only upon receipt thereof):

             If to BMS, addressed to:

                            Bristol-Myers Squibb Company
                            Route 206 and Province Line Road
                            Princeton, New Jersey  08540
                            Attention:  Vice President, Licensing

             If to Pilot, addressed to:

                            Pilot Therapeutics, Inc.
                            101 N.  Chestnut Street
                            Albert Hall
                            Winston Salem, North Carolina  27101
                            Attention:  Beth Fordham-Meier, Vice President,
                            Business Development

         10.6 Amendment. No amendment, modification or supplement of any
provision of this Agreement shall be valid or effective unless made in writing
and signed by each party.

                                       32
<PAGE>
         10.7 Waiver. No provision of this Agreement shall be waived by any act,
omission or knowledge of a party or its agents or employees except by an
instrument in writing expressly waiving such provision and signed by the waiving
party.

         10.8 Counterparts. This Agreement may be executed in two counterparts;
both such counterparts taken together shall constitute one and the same
instrument.

         10.9 Descriptive Headings. The descriptive headings of this Agreement
are for convenience only and shall be of no force or effect in construing or
interpreting any of the provisions of this Agreement.

         10.10 Governing Law; Submission to Jurisdiction.

               (a) THIS AGREEMENT SHALL BE GOVERNED BY, AND INTERPRETED AND
CONSTRUED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK, WITHOUT GIVING
EFFECT TO CONFLICT OF LAWS PRINCIPLES.

               (b) Pilot hereby irrevocably submits to the jurisdiction of any
New York State or Federal court sitting in the Borough of Manhattan, The City of
New York, in any action or proceeding arising out of or relating to this
Agreement or the Sublicensee Indemnity, and Pilot hereby irrevocably agrees that
all claims in respect of such action or proceeding may be heard and determined
in such court. Pilot hereby waives, to the fullest extent it may effectively do
so, the defense of an inconvenient forum to the maintenance of such action or
proceeding. Pilot agrees that a final judgment in any such action or proceeding
shall be conclusive and may be entered in other jurisdictions by suit on the
judgment or in any other manner provided by law.

         10.11 Severability. Whenever possible, each provision of this Agreement
will be interpreted in such manner as to be effective and valid under applicable
law, but if any provision

                                       33
<PAGE>
of this Agreement is held to be prohibited by or invalid under applicable law,
such provision will be ineffective only to the extent of such prohibition or
invalidity, without invalidating the remainder of this Agreement.

         10.12 Entire Agreement of the Parties. This Agreement constitutes and
contains the entire understanding and agreement of the parties and cancels and
supersedes any and all prior negotiations, correspondence, understandings and
agreements, whether oral or written, between the parties respecting the subject
matter hereof.

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of the date first above written.

                            PILOT THERAPEUTICS, INC.

                            By:    /s/ Beth W. Fordham-Meier
                               ------------------------------------------------
                            Name:  Beth W. Fordham-Meier
                                 ----------------------------------------------
                            Title: Vice President, Corporate Development &
                                   Planning
                                   --------------------------------------------

                            BRISTOL-MYERS SQUIBB COMPANY

                            By:    /s/Steven E. Benner, MD
                               ------------------------------------------------
                            Name:  Steven E. Benner, MD
                                 ----------------------------------------------
                            Title: Vice President Licensing
                                  ---------------------------------------------

                                       34
<PAGE>
                                                                       EXHIBIT A

                         Patents and Patent Applications

Countries in which the Patent Applications have been or will be made and in
which the Patents will be maintained: Australia, Austria, Belgium, Canada,
Denmark, Finland, France, Germany, Great Britain, Greece, Ireland, Italy, Japan,
Liechtenstein, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden,
Switzerland and the United States of America.

See the attached table setting forth the Patents and Patent Applications.

                                       35

<PAGE>
                                                            EXHIBIT A, CONTINUED

                         Patents and Patent Applications

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
Country          Application number      Filing date         Patent number           Grant date              Expiration date
-----------------------------------------------------------------------------------------------------------------------------------
<S>              <C>                     <C>                 <C>                    <C>                      <C>
AUSTRALIA        54717/96                JUN/05/1996         693352                 NOV/05/1998                JUN/05/2016
-----------------------------------------------------------------------------------------------------------------------------------
AUSTRIA          96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
BELGIUM          96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
CANADA           2175854                 MAY/06/1996                                                           MAY/06/2016
-----------------------------------------------------------------------------------------------------------------------------------
DENMARK          96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
EUR PATENT       96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
FINLAND          96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
FRANCE           96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
GREAT BRITAIN    96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
GERMANY          96401097.9              MAY/20/1996         69603322.4-08          JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
GREECE           96401097.9              MAY/20/1996                                                           MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
IRELAND          96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
ITALY            96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
JAPAN            8-142621                JUN/05/1996                                                           JUN/05/2016
-----------------------------------------------------------------------------------------------------------------------------------
LIECHTENSTEIN    96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
LUXEMBOURG       96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
MONACO           96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                       36
<PAGE>
                                                            EXHIBIT A, CONTINUED

                         Patents and Patent Applications

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
Country          Application number      Filing date         Patent number           Grant date              Expiration date
-----------------------------------------------------------------------------------------------------------------------------------
<S>              <C>                     <C>                 <C>                    <C>                      <C>
-----------------------------------------------------------------------------------------------------------------------------------
NETHERLANDS      96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
PORTUGAL         96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
SPAIN            96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
SWEDEN           96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
SWITZERLAND      96401097.9              MAY/20/1996         0747347                JUL/21/1999                MAY/20/2016
-----------------------------------------------------------------------------------------------------------------------------------
U.S.A.           08/467429               JUN/06/1995         5624957                APR/29/1997                JUN/06/2015
-----------------------------------------------------------------------------------------------------------------------------------
U.S.A.           08/724979               OCT/04/1996         5760084                JUN/02/1998                JUN/06/2015
-----------------------------------------------------------------------------------------------------------------------------------
U.S.A.           60/101747               SEP/24/1998                                                           SEP/24/1999
-----------------------------------------------------------------------------------------------------------------------------------
U.S.A.           60/125891               MAR/24/1999                                                           MAR/24/2000
-----------------------------------------------------------------------------------------------------------------------------------
EUR PATENT       PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
PAT COOP TREATY  PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
U.S.A.           09/401356               SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
JAPAN            PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
CANADA           PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
AUSTRALIA        PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
MEXICO           PCT/US99/21920          SEP/21/1999                                                           SEP/21/2019
-----------------------------------------------------------------------------------------------------------------------------------
CHINA P.R.       PCT/US99/21920          SEP/21/1999
-----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                       37
<PAGE>
                                                                       EXHIBIT B

                         Description of Certain Studies

             PLT 99511: RAR(y)-(GAMMA) SELECTIVE ORAL RETINOID FOR
                          THE TREATMENT OF CYSTIC ACNE

                   DEVELOPMENT PLAN: PRECLINICAL TO PHASE IIA

The utility of a class of drugs known as the Retinoids for the treatment of
acne, psoriasis and precancerous/cancerous conditions is well established in
clinical medicine. Oral retinoids, including the anti-acne drug 13-cis retinoic
acid(Accutane, Roche), the anti-psoriasis drug acitretin(Etretin, Roche) and
all-trans-retinoic acid(Vesanoid, Roche) for the treatment of acute
promyelocytic leukemia are known to induce hypertriglyceridemia as one side
effect. While the elevations are usually twofold or less, levels that are
generally asymptomatic, some patients respond with severe elevations, which can
lead to pancreatitis. Consequently, patients treated with oral retinoids are
routinely monitored for serum triglyceride elevations, adding to the cost of
treatment.

An RAR-(y)(gamma) selective retinoid discovered by Bristol-Myers Squibb,
BMS-189961 (PLT 99511 is the active enantiomer of this compound), has been
reported to be free of this side effect while maintaining efficacy in animal
models of acne.(1, 2) If this activity profile is also observed in humans, PLT
99511 would be a desirable drug from both clinical and pharmacoeconomic
perspectives.

This document outlines the early development plan of PLT 99511. The
developmental objective is to determine the safety and efficacy of this retinoid
in the treatment of nodular cystic acne in a proof-of-principle study. To
support the proof-of-principle trial all necessary preclinical and Phase I
safety studies will be performed. The decision to continue further development
will be based on comparison of safety and efficacy responses that are observed
with PLT 99511 to the standard therapy Accutane. If the desired clinical
endpoints are achieved Pilot Therapeutics will seek are partner to complete the
development to product registration. The clinical trials will be conducted under
a US IND. The timeline for this project to Phase IIa proof-of-principle is shown
in the attached Gantt chart.

BULK DRUG SUBSTANCE AND FORMULATION

A single batch of PLT 99511 will be prepared to meet all of the bulk
requirements for IND toxicity testing and manufacture of clinical supplies.
Formulation selection will depend on the physical properties of the compound.
Due to aqueous solubility limitations, retinoids are most commonly administered
as solubilized forms in soft gelatin capsules. However, solid formulations will
also be considered after assessing pharmacokinetic properties in animals.
Limited stability studies will be conducted on both the bulk drug and the drug
formulation.

<PAGE>

ANALYTICAL METHODS

To control quality of the bulk drug substance and product, analytical methods
will be developed to control identity, potency and purity. These validated
methods will also support the various IND stability studies needed and generate
data needed to set specifications for release of clinical supplies.

TOXICOLOGY

Pre-IND toxicology studies will be designed to determine a safe maximum dose for
Phase I studies. These studies will consist of single dose oral studies in rats
and mice and two-week oral studies in one rodent and one non-rodent species.
Required genotoxicity studies will be conducted. After decision to proceed to
phase II, 6-month studies in two species will be conducted to support the
proof-of principle study.

VI.      METABOLISM AND PHARMACOKINETICS

Validated assays for quantifying PLT 99511 in plasma will be developed to
support formulation development, toxicology and the Phase I clinical study. The
pharmacokinetic study design and data analysis will allow the determination of
key parameters such as CMAX, TMAX, AUC, and T-HALF. Other pharmacokinetic
parameters will be calculated as necessary.

V.       CLINICAL RESEARCH

The objectives of the Phase I trials are to determine the safety and
tolerability of single and multiple ascending oral doses of PLT 99511 conducted
under a US IND. Pharmacokinetic data will also be collected. The establishment
of the maximum tolerated dose in the multiple ascending dose study will be lead
to a decision on the optimal dose for the phase IIa efficacy study. The
evaluation of retinoid specific biomarkers or early signs of efficacy may be
included in these studies.

Once safety and confirmation of the lack of effect on serum lipids is
established in the phase I studies, a phase IIa study will be initiated. This
proof-of principle study will be conducted in males with severe nodular cystic
acne. The trial will be a single center, single dose, double-blind, randomized,
placebo and Accutane controlled study designed to evaluate potential clinical
and safety advantages of PLT 99511 compared to Accutane. Dosing is anticipated
to be qd for up to 12 weeks with a 4 week regression peroid. Clinical efficacy
will be assessed using standard endpoints for acne studies. In addition,
potential biomarkers of efficacy will be measured and their correlation to
clinical endpoints attempted.

                                       39
<PAGE>

1.       Tramposch, K.M., Beehler, B., Chen, S., Whiting, G., Hammar, L.,
         Roalsvig, T. Ostrowski, J. Reczek, P. Swann, T. Zusi, F.C., Separation
         of skin activity from hypertriglyceridemia using an orally active
         RAR-(y)(gamma) specific retinoid. J. Invest. Dermatol., 108:579, 1997.

2.       Swann, R.T., Smith, D., Tramposch, K.M., Zusi, F.C., RAR-(y)(gamma)
         specific retinobenzoic acid derivatives. U.S. Patent number 5,624,957,
         April 29, 1997.

                                       40
<PAGE>

                                                                       EXHIBIT C

                    Available Intermediate and Drug Supplies

<TABLE>
<CAPTION>
Compound                   Approximate Quantity      Price
--------                   --------------------      -----
<S>                        <C>                       <C>
BMS-290,394-01                  **                     **

BMS-297,316                     **                    $**
</TABLE>

                                       41
<PAGE>

                                                                       Exhibit D

                               INDEMNITY AGREEMENT

         THIS INDEMNITY AGREEMENT (this "Agreement"), is entered into as of [
__________, _____, ] between BRISTOL-MYERS SQUIBB COMPANY, a Delaware
corporation ("BMS"), and [ _______________, ] a [ ________ ] corporation
("Guarantor").

                             PRELIMINARY STATEMENTS

         A.       BMS and PILOT THERAPEUTICS, INC., a North Carolina corporation
("Pilot") are parties to that certain License Agreement dated as of
[____________ ], 2001 (the "License Agreement").

         B.       As a condition to granting Pilot certain of its rights under
the License Agreement, including, without limitation, Pilot's right to grant
sublicenses, each of Pilot's sublicensees and, in certain circumstances, their
Affiliates, must execute and deliver a copy of this Agreement to set forth and
establish such sublicensee's joint and several (together with Pilot and all
other parties executing and delivering copy of this Agreement "Sublicense
Guarantors") obligation to BMS regarding Pilot's indemnification obligations
under the License Agreement.

         C.       Following the execution and delivery of this Agreement, Pilot
and [Guarantor or _______________, an Affiliate of Guarantor,] are permitted to
enter into a sublicense to and in accordance with the License Agreement (the
"Sublicense Agreement"). Capitalized terms used herein and not otherwise defined
shall have the meanings ascribed to them in the License Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and agreements
of the parties hereinafter contained, the parties agree as follows:

1.       GUARANTOR'S OBLIGATIONS.

         1.1.     Guarantor hereby acknowledges receipt of a correct and
complete copy of the License Agreement existing on the date hereof, and consents
to all of the terms and provisions thereof, as the same may be from time to time
amended or supplemented, except that amendments or supplements that would
reasonably be expected to materially adversely affect Pilot's Obligations (as
defined below) shall require the written consent of Guarantor, which will not be
unreasonably withheld or delayed.

         1.2.     Guarantor has reviewed the License Agreement with its counsel
and has a full and complete understanding of all of the indemnification
obligations undertaken by Pilot in the License Agreement, including, without
limitation, those obligations set forth in Article 5 and Article 8 of the
License Agreement ("Pilot's Obligations").

                                       42
<PAGE>

         1.3.     Upon the execution and delivery of a definitive Sublicense
Agreement to [Guarantor or _______________, an Affiliate of Guarantor,],
Guarantor hereby agrees that:

                  A.       Guarantor shall, together with Pilot and all other
                  Sublicense Guarantors, whether existing now or at any time in
                  the past or the future, be (i) jointly and severally liable
                  for all of Pilot's Obligations and all indemnity obligations
                  of all other Sublicense Guarantors pursuant to each such
                  Sublicense Guarantors' executed copies of this Agreement
                  entered in accordance with the License Agreement, including,
                  but not limited to, such indemnity obligations arising from
                  acts or omissions of such other Sublicense Guarantors, whether
                  such Pilot's Obligations or such indemnity obligations arise
                  before or after the execution of this Agreement, and (ii)
                  responsible for ensuring that all of Pilot's Obligations are
                  carried out in accordance with the License Agreement; and

                  B.       Guarantor shall fully perform Pilot's Obligations
                  under the License Agreement and, where Pilot is required under
                  the License Agreement to indemnify BMS, pay such amounts in
                  full when due and payable, this being a guaranty of
                  indemnification and payment and not merely of collection and
                  being in no way conditional or contingent; and in any case
                  when any part of Pilot's Obligations shall not have been paid
                  when due and payable, Guarantor hereby agrees, forthwith upon
                  notice from BMS, to pay or cause to be paid to BMS the amount
                  thereof as is then due and payable and unpaid.

2.       REPRESENTATIONS AND WARRANTIES. Guarantor hereby represents and
warrants to BMS as follows:

         2.1.     Guarantor is a corporation duly organized, validly existing
         and in good standing under the law of [ ___________ ] with corporate
         powers adequate for executing and delivering, and performing its
         obligations under, this Agreement;

         2.2.     The execution, delivery and performance of this Agreement have
         been duly authorized by all necessary corporate action on the part of
         Guarantor;

         2.3.     This Agreement has been duly executed and delivered by
         Guarantor and is a legal, valid and binding obligation Guarantor,
         enforceable against Guarantor in accordance with its terms; and

         2.4.     The execution, delivery and performance of this Agreement do
         not and will not conflict with or contravene any provision of the
         charter documents or by-laws of Guarantor or any material agreement,
         document, instrument, indenture or other obligation of Guarantor.

         2.5.     Guarantor acknowledges the adequacy and sufficiency of the
         consideration given by BMS in exchange for the obligations undertaken
         by Guarantor hereunder, including, without limitation, the execution
         and delivery of the License Agreement, the license rights and right to
         sublicense granted to Pilot thereunder, and BMS' legitimate need for

                                       43
<PAGE>

         the indemnification acquired through this Agreement in connection with
         such license and sublicense of such rights to Guarantor or its
         Affiliates.

3.       GENERAL PROVISIONS.

         3.1.     GOVERNING LAW. This Agreement shall be governed and construed
in accordance with the laws of the State of New York without giving effect to
any conflict of laws provisions. Any action or proceeding brought to enforce the
rights or obligations of any Party hereto under this Agreement may be commenced
and maintained in any New York State or U.S. Federal court sitting in the
Borough of Manhattan, The City of New York. Such court shall have non-exclusive
jurisdiction over any such action, suit or proceeding brought by any of the
Parties hereto. Each of the Parties hereto further agrees that process emanating
from such courts may be served upon it by certified mail, return receipt
requested, submits, personally appears, and consents to the exercise of
jurisdiction over it and its properties with respect to any action, suit or
proceeding arising out of or in connection with this Agreement or the
transactions contemplated hereby or the enforcement of any rights under this
Agreement or in connection with any claim arising directly or indirectly under
this Agreement and waives any and all jurisdictional defenses and objections to
venue. The Guarantor agrees that a final judgment in any such action or
proceeding shall be conclusive and may be entered in other jurisdictions by suit
on the judgment or in any other manner provided by law.

         3.2.     LEGAL FEES. The prevailing party in any proceeding to enforce
this Agreement shall be entitled to recover its reasonable attorneys' fees,
costs and expenses incurred in connection with such proceeding, in addition to
any other relief that may be awarded.

         3.3.     ENTIRE AGREEMENT. This Agreement, together with the License
Agreement and the Sublicense Agreement, contains the entire agreement between
the parties with respect to the subject matter hereof, and prior or collateral
representations, promises or conditions in connection with or in respect to the
subject matter hereof that are not incorporated herein are not binding upon
either of the parties. This Agreement, together with the License Agreement and
the Sublicense Agreement, supersedes all prior communications, representations
or agreements between the parties, whether verbal or written.

         3.4.     HEADINGS AND TITLES. Headings or captions used herein are for
convenience only and shall not constitute a part hereof or affect in any way the
meaning or interpretation of this Agreement.

         3.5.     SEVERABILITY. The invalidity, illegality or unenforceability
of any one or more provisions of this Agreement shall in no way affect or impair
the validity, legality or enforceability of the remaining provisions, hereof,
which shall remain in full force and effect.

         3.6.     WAIVER. No failure by any party to insist upon the strict
performance of any covenant, duty, agreement or condition of this Agreement or
to exercise any right or remedy upon a breach thereof shall constitute a waiver
of any such breach or any other covenant, agreement, term or condition. No
waiver shall be binding unless executed in writing by the party making the
waiver.

                                       44
<PAGE>

         3.7.     ASSIGNMENT. Neither this Agreement nor any obligation
hereunder may be assigned of delegated by the Guarantor without the prior
written consent of BMS. In the event of a merger involving the Guarantor, this
Guaranty shall become binding upon and enforceable against any successor by
merger, and the owner of 50% or more of the total equity capital of any such
successor by merger, if any, shall become jointly and severally liable and
responsible for the performance and observance of all the Guarantor's duties and
obligations hereunder, and shall execute and deliver to BMS an indemnity
agreement in the form of this Agreement. Guarantor's Obligations shall be
binding on the Guarantor's successors and permitted assigns.

         3.8.     SURVIVAL. This Agreement will survive the expiration or
termination of, and shall not be reduced, modified or affected in any way by the
amendment of, the License Agreement, the Sublicense Agreement or any sublicense
agreement between Pilot and the Guarantor.

         3.9.     NOTICES. All notices and other communications hereunder shall
be in writing and shall be deemed given if delivered personally, mailed by
registered or certified mail (return receipt requested), postage prepaid, or
sent by overnight courier service to the parties at the following addresses (or
at such other address for a party as shall be specified by like notice; provided
that notices of a change of address shall be effective only upon receipt
thereof):

         If to Guarantor, addressed to:

                       [Name of Guarantor]
                       [Address]
                       Attention:  [ ___________________ ]

         If to BMS, addressed to:
                       Bristol-Myers Squibb Company
                       Route 206 and Province Line Road
                       Princeton, New Jersey  08540
                       Attention:  Vice President, Licensing

         3.10.    MODIFICATIONS. No modification, amendment, extension, renewal,
rescission, termination or waiver of any of the provisions contained herein, or
any future representation, promise or condition in connection with the subject
matter hereof, shall be binding upon either party unless in writing and signed
by an officer on its behalf.

         3.11.    COUNTERPARTS. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

         IN WITNESS WHEREOF, each the parties hereto have caused this Agreement
to be executed on the date first written above.

                                       45
<PAGE>

GUARANTOR:

[ ________________________________________ ]

By:      [ _______________________________ ]

Name:    [ _______________________________ ]

Title:   [ _______________________________ ]

BRISTOL-MYERS SQUIBB COMPANY

By:      [ _______________________________ ]

Name:    [ _______________________________ ]

Title:   [ _______________________________ ]

                                       46
<PAGE>

                                                                       EXHIBIT E

                             Acceptable Sublicensees

                                       **

                                       47<PAGE>
                                                                  EXHIBIT 10.45

                                  [UTEK LOGO]

                      STRATEGIC ALLIANCE AGREEMENT BETWEEN

                                UTEK CORPORATION
                                       AND
                                 BITZMART, INC.
--------------------------------------------------------------------------------

         This Agreement is made and entered into this 14th day of August 2001,
by and between UTEK CORPORATION ("UTEK"), 202 South Wheeler Street, Plant City,
Florida 33566 a Delaware Corporation, and BITZMART, INC., 203 N. Wabash Ave.,
Suite 1805, Chicago, IL, a Colorado corporation.

                                   WITNESSETH:

         WHEREAS, BITZMART, INC. desires to engage UTEK to provide the services
as set forth in this Agreement, and

         WHEREAS, UTEK is agreeable to provide these services.

         NOW THEREFORE, in consideration of the mutual promise made in this
Agreement, and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto agree as
follows:

I.       ENGAGEMENT

BITZMART, INC. hereby retains UTEK to provide those services as defined herein
and UTEK hereby agrees to the appointment on the terms and conditions
hereinafter set forth and agrees to use its best efforts in providing said
services.

II.      INDEPENDENT CONTRACTOR

UTEK shall be, and in all respects be deemed to be, an independent contractor in
the performance of its duties hereunder.

         A.       BITZMART, INC. shall be solely responsible for making all
                  payments to and on behalf of its employees and UTEK shall in
                  no event be liable for any debts or other liabilities of
                  BITZMART, INC..

         B.       UTEK shall not have or be deemed to have, fiduciary
                  obligations or duties to BITZMART, INC., and shall be able to
                  pursue, conduct and carry on for its own account (or for the
                  account of others) such activities, ventures, businesses and
                  other pursuits as UTEK in its sole, absolute and unfettered
                  discretion, may elect.

         C.       Notwithstanding the above, no activity, venture, business or
                  other pursuit of UTEK, during the term of this Agreement shall
                  conflict with UTEK's obligations under this Agreement.

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 1
<PAGE>

III      SERVICES

UTEK agrees to provide the following services, hereinafter collectively referred
to as "Services" as a consultant to BITZMART, INC.: To provide business
development services, including the identification, evaluation and presentation
of potential technology and business merger and acquisition opportunities.

         A.       UTEK shall devote such time and efforts, as it deems
                  commercially reasonable, under the circumstances to the
                  affairs of the BITZMART, INC., as is reasonable and adequate
                  to render the Services contemplated by this Agreement.

         B.       UTEK cannot guarantee results on behalf of BITZMART, INC., but
                  shall pursue all reasonable avenues available through its
                  network of contacts. The acceptance and consumption of any
                  transaction is subject to acceptance of the terms and
                  conditions by BITZMART, INC. in its sole discretion.

         C.       In conjunction with the Services, UTEK agrees to:

                  1.       Make itself available at the offices of BITZMART,
                           INC. or at another mutually agreed upon place, during
                           normal business hours, for reasonable periods of
                           time, subject to reasonable advance notice and
                           mutually convenient scheduling.

                  2.       Make itself available for telephone conferences with
                           the principal officer(s) of BITZMART, INC. during
                           normal business hours.

                  3.       Advise BITZMART, INC. as to the status of potential
                           technology acquisitions and business merger
                           opportunities.

IV.      EXPENSES

It is expressly agreed and understood that each party shall be responsible for
its own normal and reasonable out-of-pocket expenses.

V.       COMPENSATION

         A.       In consideration for the services, BITZMART, INC. agrees that
                  UTEK shall be entitled to compensation as follows:

                  Upon executing this Agreement, BITZMART, INC. shall issue to
                  UTEK 100,000 common shares of BITZMART, INC.

VI.      LEGAL COMPLIANCE

BITZMART, INC. agrees that it will put in place, if it has not already done so,
policies and procedures relating to and addressing, with the commercially
reasonable intent to ensure compliance with, applicable securities laws, rules
and regulations, including, but not limited to:

         A.       The use, release or other publication of forward-looking
                  statements.

         B.       Disclosure requirements regarding the required disclosure of
                  the nature and terms of UTEK's relationship with BITZMART,
                  INC., including, but not limited to press releases,
                  publications on its web site, letters to investors and

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 2
<PAGE>

                  telephone or other personal communication with potential or
                  current investors.

         C.       NO PRESS RELEASES OR ANY OTHER FORMS OF COMMUNICATION TO THIRD
                  PARTIES WHICH MENTION UTEK CORPORATION OR BITZMART, INC. SHALL
                  BE RELEASED WITHOUT THE PRIOR WRITTEN CONSENT AND APPROVAL OF
                  BOTH UTEK AND BITZMART, INC.

         D.       EXECUTION. The execution, delivery and performance of this
                  Agreement, in the time and manner herein specified, will not
                  conflict with, result in a breach of, or constitute a default
                  under any existing agreement, indenture, or other instrument
                  to which either BITZMART, INC. or UTEK is a party or by which
                  either entity may be bound or affected.

         E.       TIMELY APPRISALS. BITZMART, INC. shall use its commercially
                  reasonable efforts to keep UTEK up to date and apprised of all
                  business, market and legal developments related to BITZMART,
                  INC. and its relationship to UTEK.

         F.       CORPORATE AUTHORITY. Both BITZMART, INC. and UTEK have full
                  legal authority to enter into this Agreement and perform the
                  same in the time and manner contemplated.

         G.       The individuals whose signatures appear below are authorized
                  to sign this Agreement on behalf of their respective
                  corporations.

         H.       BITZMART, INC. will cooperate with UTEK and will promptly
                  provide UTEK with all pertinent materials and requested
                  information in order for UTEK to perform is Services pursuant
                  to this Agreement.

         I.       When delivered, the shares of BITZMART, INC.'s Common Stock
                  shall be duly and validly issued, fully paid and
                  non-assessable.

         J.       UTEK represents and warrants to BITZMART, INC. that a) it has
                  the Experience and ability as may be necessary to perform all
                  the required Services with a high standard of quality, b) all
                  Services will be performed in a professional manner, and c)
                  all individuals it provides to perform the Services will be
                  appropriately qualified and subject to appropriate agreements
                  concerning the protection of trade secrets and confidential
                  information of BITZMART, INC. which such persons may have
                  access to over the term of this Agreement.

         K.       Until termination of the engagement, BITZMART, INC. will
                  notify UTEK promptly of the occurrence of any event, which
                  might materially effect the condition (financial or
                  otherwise), or prospects of BITZMART, INC.

VII.     TERM AND TERMINATION

         The term of the Agreement shall commence upon the execution of this
         Agreement and terminate on September 30, 2002.

VIII.    CONFIDENTIAL DATA

         A.       UTEK shall not divulge to others, any trade secret or
                  confidential information,

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 3
<PAGE>

                  knowledge, or data concerning or pertaining to the business
                  and affairs of BITZMART, INC., obtained by UTEK as a result of
                  its engagement hereunder, unless authorized, in writing by
                  BITZMART, INC. UTEK represents and warrants that it has
                  established appropriate internal procedures for protecting the
                  trade secrets and confidential information of BITZMART, INC.,
                  including, without limitation, restrictions on disclosure of
                  such information to employees and other persons who may be
                  engaged in such information to employees and other persons who
                  may be engaged in rendering services to any person, firm or
                  entity which may be competitor of BITZMART, INC.

         B.       BITZMART, INC. shall not divulge to others, any trade secret
                  or confidential information, knowledge, or data concerning or
                  pertaining to the business and affairs of UTEK obtained as a
                  result of its engagement hereunder, unless authorized, in
                  writing, by UTEK.

         C.       UTEK shall not be required in the performance of its duties to
                  divulge to BITZMART, INC., or any officer, director, agent or
                  employee of BITZMART, INC., any secret or confidential
                  information, knowledge, or data concerning any other person,
                  firm or entity (including, but not limited to, any such
                  person, firm or entity which may be a competitor or potential
                  competitor of BITZMART, INC.) which UTEK may have or be able
                  to obtain other than as a result of the relationship
                  established by this Agreement.

IX.      OTHER MATERIAL TERMS AND CONDITIONS

         A.       INDEMNITY.

                  1.       UTEK shall indemnify, defend and hold harmless
                           BITZMART, INC. from and against any and all losses
                           incurred by BITZMART, INC. which arise out of or
                           result from misrepresentation, breach of warranty or
                           breach or non- fulfillment of any covenant contained
                           herein or Schedules annexed hereto or in any other
                           documents or instruments furnished by UTEK pursuant
                           hereto or in connection with this Agreement.

                  2.       BITZMART, INC. shall indemnify, defend and hold
                           harmless UTEK from and against any and all losses
                           incurred by UTEK which arise out of or result from
                           misrepresentation, breach of warranty or breach or
                           non-fulfillment of any covenant contained herein or
                           Schedules annexed hereto or in any other documents or
                           instruments furnished by BITZMART, INC. pursuant
                           hereto or in connection with this Agreement.

         D.       PROVISIONS. Neither termination nor completion of the
                  assignment shall affect the provisions of this Agreement, and
                  the Indemnification Provisions that are incorporated herein,
                  which shall remain operative and in full force and effect.

         E.       ADDITIONAL INSTRUMENTS. Each of the parties shall from time to
                  time, at the request of others, execute, acknowledge and
                  deliver to the other party any and all further instruments
                  that may be reasonably required to give full effect and force
                  to the provisions of this Agreement.

         F.       ENTIRE AGREEMENT. Each of the parties hereby covenants that
                  this Agreement, is intended to and does contain and embody
                  herein all of the understandings and agreements, both written
                  or oral, of the parties hereby with

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 4
<PAGE>

                  respect to the subject matter of this Agreement, and that
                  there exists no oral agreement or understanding expressed or
                  implied liability, whereby the absolute, final and
                  unconditional character and nature of this Agreement shall be
                  in any way invalidated, empowered or affected. There are no
                  representations, warranties or covenants other than those set
                  forth herein.

         G.       LAWS OF THE STATE OF FLORIDA. This Agreement shall be deemed
                  to be made in, governed by and interpreted under and construed
                  in all respects in accordance with the laws of the State of
                  Florida, irrespective of the country or place of domicile or
                  residence of either party. In the event of controversy arising
                  out of the interpretation, construction, performance or breach
                  of this Agreement, the parties hereby agree and consent to the
                  jurisdiction and venue of Hillsborough County, Florida, or the
                  United States District Court for the Middle District of
                  Florida, and further agree and consent that personal service
                  or process in any such action or proceeding outside of the
                  State of Florida and Hillsborough County shall be tantamount
                  to service in person within Hillsborough County, Florida and
                  shall confer personal jurisdiction and venue upon either of
                  said Courts.

         H.       ASSIGNMENTS. The benefits of the Agreement shall inure to the
                  respective successors and assignees of the parties and assigns
                  and representatives, and the obligations and liabilities
                  assumed in this Agreement by the parties hereto shall be
                  binding upon their respective successors and assigns; provided
                  that the rights and obligations of UTEK under this Agreement
                  may not be assigned or delegated without the prior written
                  consent of BITZMART, INC. and any such purported assignment
                  shall be null and void. Notwithstanding the foregoing, UTEK
                  may assign this Agreement or any portion of its Compensation
                  as outlined herein to its subsidiaries in its sole discretion.

         I.       ORIGINALS. This Agreement may be executed in any number of
                  counterparts, each of which so executed shall be deemed an
                  original and constitute one and the same agreement.

         J.       ADDRESSES OF PARTIES. Each party shall at all times keep the
                  other informed of its principal place of business if different
                  from that stated herein, and shall promptly notify the other
                  of any change, giving the address of the new place of business
                  or residence.

         K.       NOTICES. All notices that are required to be or may be sent
                  pursuant to the provision of this Agreement shall be sent by
                  certified mail, return receipt requested, or by overnight
                  package delivery service to each of the parties at the
                  addresses appearing herein, and shall count from the date of
                  mailing or the validated air bill.

         L.       MODIFICATION AND WAVIER. A modification or waiver of any of
                  the provisions of this Agreement shall be effective only if
                  made in writing and executed with the same formality as this
                  Agreement. The failure of any party to insist upon strict
                  performance of any of the provisions of this Agreement shall
                  not be construed as a waiver of any subsequent default of the
                  same or similar nature or of any other nature.

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 5
<PAGE>

         M.       INJUNCTIVE RELIEF. Solely by virtue of their respective
                  execution of this Agreement and in consideration for the
                  mutual covenants of each other, BITZMART, INC. and UTEK hereby
                  agree, consent and acknowledge that, in the event of a breach
                  of any material term of this Agreement, the non-breaching
                  party will be without adequate remedy-at-law and shall
                  therefore, be entitled to immediately redress any material
                  breach of this Agreement by temporary or permanent injunctive
                  or mandatory relief obtained in an action or proceeding
                  instituted in Hillsborough County, State of Florida, or the
                  United States District Court for the Middle District of
                  Florida without the necessity of proving damages and without
                  prejudice to any other remedies which the non-breaching party
                  may have at law or in equity. For the purposes of this
                  Agreement, each party hereby agrees and consents that upon a
                  material breach of this Agreement as aforesaid, in addition to
                  any other legal and/or equitable remedies, the non-breaching
                  party may present a conformed copy of this Agreement to the
                  aforesaid courts and shall thereby be able to obtain a
                  permanent injunction enforcing this Agreement or barring,
                  enjoining or otherwise prohibiting the other party from
                  circumventing the express written intent of the parties as
                  enumerated in this Agreement.

         N.       ATTORNEY'S FEES. If any arbitration, litigation, action, suit,
                  or other proceeding is instituted to remedy, prevent or obtain
                  relief from a breach of this Agreement, in relation to a
                  breach of this Agreement or pertaining to a declaration of
                  rights under this Agreement, the prevailing party will recover
                  all such party's attorneys' fees incurred in each and every
                  such action, suit or other proceeding, including any and all
                  appeals or petitions therefrom. As used in this Agreement,
                  attorneys' fees will be deemed to be the full and actual cost
                  of any legal services actually performed in connection with
                  the matters involved, including those related to any appeal to
                  the enforcement of any judgment calculated on the basis of the
                  usual fee charged by attorneys performing such services.

APPROVED AND AGREED:

UTEK CORPORATION                          BITZMART, INC.

By:                                       By:
   -----------------------------             ---------------------------------
   Clifford M. Gross, Ph.D., CEO             Howard Leventhal, President & CEO

--------------------------------          ------------------------------------
Date                                      Date

If you are in agreement with the foregoing, please execute and return one copy
of this agent to the undersigned. Thank you.

         UTEK/BITZMART, INC. Strategic Alliance Agreement..........Page 6

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