Document:

Offer Letter, dated August 3, 2006

 Exhibit 10.6 
 August 3, 2006 
 Ms. Roya Behnia 
 4144 North Rockwell Street 
 Chicago, Illinois 60618 
  

	 	Re:	Employment 

 Dear Roya:

 We are pleased to offer you employment with Rewards Network Inc. (“Rewards Network”) as Senior Vice President, General Counsel,
Secretary and Chief Privacy Officer. In this position, you will report to me, and will perform duties as we discussed. Should you accept this offer, your start date will be August 4, 2006 and your gross annual salary initially will be $250,000
(less any withholdings and deductions required by law or authorized by you), which generally will be payable in biweekly installments. In 2006 and beyond, you will be entitled to participate in the senior management bonus program, the specific terms
of which are approved annually by the Compensation Committee of the Board of Directors. For the 2006 bonus program, you will be eligible for a bonus that is equal to up to 50% of your annual base salary pro rated for the amount of actual time
employed by Rewards Network. You also will be eligible to participate in the 2006 Long Term Incentive Plan subject to the terms and conditions of such plan. In 2006, you will be eligible for a grant target equivalent to 55% of your salary pro rated
for the amount of actual time employed by Rewards Network as approved by the Compensation Committee. 
 Furthermore, you will be eligible to
participate in such Rewards Network’s employee benefit plans and policies including plans and policies relating to health, life, severance, 401(k) Plan, disability, etc. benefits that Rewards Network may make available generally to its
employees in comparable positions, subject to the terms and conditions of any such plans and policies as they may exist from time to time. In addition, you will be entitled to 24 days of paid time off for your first year. Rewards Network reserves
the right to modify, amend, suspend, or terminate any or all such management bonus program, incentive compensation and employee benefit plans and polices at any time. 
 Please note that the purpose of this letter is merely to describe the terms of our offer. This letter does not constitute a contract of employment and does not create any right to continued employment for any period
of time. If you accept this offer, your employment with Rewards Network at all times will be “at will”. This means that either you or Rewards Network may end your employment at any time for any or no reason. 
 If your employment with Rewards Network is terminated by Rewards Network following a Change of Control (as defined below) or without Cause, or you
voluntarily terminate your employment by Rewards Network with Good Reason upon 30 days prior written notice to Rewards Network (or such shorter period as may be permitted by the Board of Directors), your entitlement to compensation and benefits
shall cease immediately, except that you will be entitled to: 
  

	 	(i)	continuation of your Base Salary for a period of 12 months after the effective date of your termination of employment; 

	 	(ii)	continued coverage of you and your spouse and dependents under Rewards Network’s group health plan for 12 months after the effective date of your termination of employment, at
no cost to you but otherwise on the same basis as such plan is offered to active employees of Rewards Network, and following the expiration of such period the right to elect continued coverage under such plan pursuant to COBRA; and

  

	 	(iii)	the continued right to exercise any outstanding vested options or restricted stock units held by you to purchase shares of Common Stock for a period of 90 days after the effective
date of your termination of employment. 

 You will not be entitled to the foregoing in the event your employment terminates
for any other reason. As used in this letter a voluntary termination of your employment with “Good Reason” shall mean a termination by you of your employment with Rewards Network pursuant to a written notice delivered to Rewards Network
within 30 days after the occurrence of the following event without your written consent; provided, that an isolated, insubstantial or inadvertent action or failure which is remedied by Rewards Network within 30 days after receipt of such notice
given by you shall not constitute Good Reason: a material diminution in your duties and responsibilities that is inconsistent with your position as Senior Vice President, General Counsel, Secretary and Chief Privacy Officer of Rewards Network, which
shall not include an adverse change in your reporting responsibilities. 
 The severance payments provided hereunder shall be made in lieu of
any other severance payments under any severance agreement, plan, program or arrangement of Rewards Network that may be applicable to you. 
 Notwithstanding anything to the contrary, no amount shall be payable to you (or your executor or other legal representative in the case of your death or disability), other than the payments and benefits described above, unless and until
eight days after you (or your executor or other legal representative in the case of your death or disability) execute and deliver to Rewards Network, a general waiver and release of claims against Rewards Network and its affiliates (other than any
claims related to the enforcement of your rights under this Agreement) in a form prescribed by Rewards Network; provided such release (A) is executed and delivered to Rewards Network within 22 days of your cessation of employment, or
such longer period of time permitted by the Board of Directors in its sole discretion and (B) and is not revoked by you (or your executor or other legal representative in the case of your death or disability) within the revocation period, if
any, made available by Rewards Network with respect to such release. 
 For purposes of this letter, a “Change in Control” shall be
deemed to have occurred if: 
  

	 	(i)	any person (as defined in Sections 3(a)(9) and 13(d)(3) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)), other than Rewards Network, Equity Group
Investments, L.L.C. (“EGI”), an affiliate of Rewards Network or EGI or an employee benefit plan of Rewards Network, acquires directly or 

 indirectly the beneficial ownership (within the meaning of Rule 13d-3 promulgated pursuant to the
Exchange Act) of any voting security of Rewards Network and immediately after such acquisition such person is, directly or indirectly, the beneficial owner of voting securities representing 50 percent or more of the total voting power of all of the
then-outstanding voting securities of Rewards Network; 
  

	 	(ii)	the individuals (i) who constitute the Board of Directors as of the Effective Date (the “Original Directors”) or (ii) who thereafter are elected to the Board of
Directors and whose election, or nomination for election, to the Board of Directors was approved by a vote of a majority of the Original Directors then still in office (such directors becoming “Additional Original Directors” immediately
following their election) or (iii) who are elected to the Board of Directors and whose election, or nomination for election, to the Board of Directors was approved by a vote of a majority of the Original Directors and Additional Original
Directors then still in office (such directors also becoming “Additional Original Directors” immediately following their election) (such individuals being the “Continuing Directors”), cease for any reason to constitute a majority
of the members of the Board of Directors; 

  

	 	(iii)	the stockholders of Rewards Network shall approve a merger, consolidation, recapitalization, or reorganization of Rewards Network, a reverse stock split of outstanding voting
securities, or consummation of any such transaction if stockholder approval is not sought or obtained, other than any such transaction which would result in at least 50 percent of the total voting power represented by the voting securities of the
surviving entity outstanding immediately after such transaction being beneficially owned (within the meaning of Rule 13d-3 promulgated pursuant to the Exchange Act) by the holders of outstanding voting securities of Rewards Network immediately prior
to the transaction, with the voting power of each such continuing holder relative to other such continuing holders not substantially altered in the transaction; or 

	 	(iv)	the stockholders of Rewards Network shall approve a plan of complete liquidation of Rewards Network or an agreement for the sale or disposition by Rewards Network of all or a
substantial portion of Rewards Network ‘s assets (i.e., 50 percent or more of the total assets of Rewards Network). 

 For
purposes of this letter, the term “Cause” shall mean any one or more of the following: 
  

	 	(i)	any willful refusal by you to follow lawful directives of the President and Chief Executive Officer or the Board of Directors which are consistent with the scope and nature of your
duties and responsibilities; provided that an isolated, insubstantial or inadvertent action or failure which is remedied by you within 10 days after written notice from the President and Chief Executive Officer or the Board of Directors shall not
constitute Cause hereunder; 

  

	 	(ii)	your conviction of, or plea of guilty or nolo contendere to, a felony or of any crime involving moral turpitude, fraud or embezzlement; 

  

	 	(iii)	any gross negligence or willful misconduct by you resulting in a material loss to Rewards Network or any of its subsidiaries, or material damage to the reputation of Rewards Network
or any of its subsidiaries; 

  

	 	(iv)	any material breach by you of any one or more of the covenants contained in the Proprietary Interest Protection and Non-Solicitation Agreement; or 

  

	 	(v)	any violation of any statutory or common law duty of loyalty to Rewards Network or any of its subsidiaries. 

 As a condition of employment with Rewards Network, you will be required to sign a Proprietary Interest Protection and Non-Solicitation Agreement, a copy
of which is attached to this letter for you to review while you consider our offer of employment. We also are extending this offer to you on the condition that you not use or disclose to Rewards Network any confidential information of anyone that
you previously worked for, and with the understanding that your Rewards Network employment will not violate or be restricted by any non-competition or other agreement with anyone else. If this is not the case, please inform us immediately.

 We congratulate you on your offer and sincerely hope that you will accept. 

 To indicate your acceptance should you decide to do so, please sign this letter and the attached
Proprietary Interest Protection and Non-Solicitation Agreement where indicated and return them to me. In the meantime, please do not hesitate to call me should you have any questions. 
  

	
	Very truly yours,
	
	 /s/ Ronald L. Blake

	Ronald L. Blake
	President and Chief Executive Officer

 Enclosure 

	cc:	Personnel File 

  

	
	AGREED TO AND ACCEPTED:
	
	 /s/ Roya Behnia

	Roya Behnia
	
	Dated: August 3, 2006License Agreement

 EXHIBIT 10.1 
 Confidential treatment has been requested for portions of this Exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated by ***. A complete version of this exhibit has been filed
separately with the Securities and Exchange Commission. 
 LICENSE AGREEMENT 
 THIS AGREEMENT, effective this 23rd day of May, 2006, between Merck Eprova AG, a Swiss corporation organized and existing under the laws of Switzerland
and with its principal place of business at Im Laternenacker 5, 8200 Schaffhausen, Switzerland (“EPRO”), and Spectrum Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 157 Technology Drive,
Irvine, California 92688, United States (“Spectrum”). EPRO and Spectrum may hereinafter each be referred to as a Party or collectively as the Parties. 
 W I T N E S S E T H, That: 
 WHEREAS, EPRO has certain technical information and patent
rights relating to the Licensed Technology (as hereinafter defined); 
 WHEREAS, Targent, Inc., a Delaware corporation
(“Targent”) and EPRO had entered into a License Agreement regarding the Licensed Technology. 
 WHEREAS, Spectrum has
acquired from Targent all rights and assets regarding the Licensed Technology and EPRO gives its consent to a transfer of such rights and assets from Targent to Spectrum. 
 WHEREAS, Spectrum desires to obtain such license under the Licensed Technology to undertake development of the Licensed Product for commercialization in the Territory in the Field of Use (all foregoing
capitalized terms as hereinafter defined) after receipt of approval from the Food and Drug Administration for the Licensed Product, and to have EPRO manufacture the active pharmaceutical ingredient (“API”) of Licensed Product for Spectrum
the same pursuant to the terms of a Manufacturing and Supply Agreement executed by EPRO and Spectrum as soon as practicable the terms of which shall be negotiated in good faith (the “Manufacturing and Supply Agreement”). 
 NOW, THEREFORE, in consideration of the promises and the mutual covenants herein contained, and other good and valuable consideration, the receipt
of which are acknowledged by the Parties, the Parties agree as follows: 
 ARTICLE I – DEFINITIONS 

 As used in this Agreement the following terms, whether singular or plural, shall have the following
meanings: 
 A. “Affiliate” shall mean any entity that owns or controls or is owned or controlled by a Party through ownership of
more than fifty percent (50%) of the stock entitled to vote for election of directors of that Party or the maximum percentage of stock interest that a foreign investor may own, whether fifty percent or less, pursuant to the local laws,
regulations or administrative orders of any country, provided the party exercises a substantial control of general policy of the company. 
 B. “Confidential Information” shall mean information ancillary to the Licensed Technology, as further defined in Article III. 
 C. “Documents” shall mean the regulatory filings made in the Territory related to the Licensed Technology, including, but not limited to, ***, *** and *** and the related orphan drug designations. 
 D. “Effective Date” shall mean the date indicated first above as the effective date of this Agreement. 
 E. “FDA” shall mean the United States Food and Drug Administration, or any successor agency thereto. 
 F. “Field of Use” shall mean all uses in the field of oncology. 
 G. “GAAP” shall mean generally accepted accounting principles in the United States or International Accounting Standards outside the United States, in each case as consistently applied by Spectrum, its
Affiliates or its Sublicensees in their respective financial statements, audited if applicable. 
 H. “Improvements” shall mean one
or more enhancements, improvements or modifications in the manufacture, formulation, ingredients, preparation, dosage, administration or packaging of a License Product or the Licensed Technology made during the term of this Agreement. 
 I. “IND” shall mean (i) an Investigational New Drug application as defined in the United States Food, Drug & Cosmetic Act and
applicable regulations promulgated thereunder, as amended from time to time or (ii) an equivalent application or filing with the applicable regulatory authority in any country other than the United States allowing the commencement of human
clinical trials. 
 J. “License” shall mean the license granted pursuant to Article II of this Agreement. 
 K. “Licensed Know-How” shall mean any technical or manufacturing 

  

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 Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission.
Confidential treatment has been requested with respect to the omitted portions. 

 
information and data, methods, processes, drawings, inventions, formulas, data on safety and efficacy, patent applications, trade secrets materials, models,
designs, prototypes or samples, relating to all forms (including but not limited to both the injectable and oral forms) of Levofolinic Acid as either the free acid or in any salt form, including any information, data, or other materials necessary or
useful for the submission to the appropriate U.S. regulatory authorities by Spectrum to obtain the registration or approval of the Licensed Product. 
 L. “Licensed Patents” shall mean those patents and patent applications in existence as of the Effective Date and listed in Exhibit A, and any divisions, re-issues, continuations and continuations-in-part or
their equivalents, and the foreign equivalents thereof. 
 M. “Licensed Product” shall mean any product in any form (including but
not limited to both the injectable and oral forms) made, have made, used, sold, or otherwise disposed of: 
  

	 	i)	which is covered by the Licensed Technology; 

  

	 	ii)	the manufacture of which requires use of the Licensed Technology; or 

  

	 	iii)	which would, but for the License granted herein, otherwise directly infringe, contributorily infringe or induce the infringement of any of the Licensed Patents.

 N. “Licensed Technology” shall mean the Licensed Patents and the Licensed Know-How of EPRO. 
 O. “Net Sales” shall mean with respect to any period for any country in the Territory, the gross receipts, by Spectrum (for purposes of this
Article I (O), the term “Spectrum” shall include Third Parties used by Spectrum to market the Licensed Product) its Affiliates or its Sublicensees, as applicable, from unrelated third parties for sales of Licensed Product, less the
following deductions if actually allowed and allocable to Licensed Product: (i) discounts, credits, rebates, allowances, adjustments, rejections, recalls, and returns for which the customer has been credited; (ii) trade, quantity, or cash
discounts or rebates customary to the industry and actually allowed, given or accrued (including, but not limited to, cash, governmental and managed care rebates, hospital or other buying group charge backs, and governmental taxes in the nature of a
rebate based on usage levels or sales of the Licensed Product); (iii) sales, excise, turnover, inventory, value-added, and similar taxes assessed on the sale of the Licensed Product; (iv) an allowance for actual transportation,
distribution, importation, insurance and other handling fees; (v) sales, transfers or dispositions of Licensed Product for charitable, promotional (including samples), pre-clinical, clinical or regulatory purposes will be excluded from Net
Sales, as will sales or transfers of Licensed Product among Spectrum and it’s Affiliates, and Sublicensees. For the avoidance of doubt, for each Licensed Product the Net Sales shall be calculated only once for the first sale of such Licensed
Product by Spectrum, its Affiliate or its Sublicensees, as the case may 

  

 3 

 
be, to a Third Party which is neither an Affiliate or Sublicensee of Spectrum. A sale of Licensed Products by Spectrum, its Affiliate or its Sublicensees to
a wholesaler, distributor or any other Third Party shall be regarded as the first sale of the Licensed Product for the purpose of calculating Net Sales. Net Sales shall not include the amount received on account of sales of a Licensed Product or of
sales of a Licensed Product in a particular country for which the term of this Agreement has expired. 
 P. “NDA” shall mean a New
Drug Application, as defined in the United States Food, Drug & Cosmetic Act and applicable regulations promulgated thereunder, as amended from time to time, to obtain approval from the FDA for commercial sale of a Licensed Product.

 Q. “Regulatory Exclusivity Period” shall mean any period of data, market or other regulatory exclusivity, including any such
periods listed in the FDA’s Orange Book. 
 R. “Sublicensee” shall mean any Third Party granted a sublicense by Spectrum of no
greater scope than granted by EPRO to Spectrum, whose identity shall be disclosed confidentially by Spectrum to EPRO prior to the execution of such Sublicense. ***. 
 S. “Territory” shall mean North America (namely, the United States and its territories and protectorates, Canada and Mexico). 
 T. “Third Party” shall mean any person or entity other than a Party or an Affiliate or Sublicensee. 
 U. ***. 
 V. “Valid Claim” shall mean a claim in any unexpired, issued patent (and as applicable, patents and patent
applications covering Improvements) within the Licensed Patents which has not been held invalid and/or unenforceable in a decision by a court or other body of competent jurisdiction from which there is no appeal or, if appealable, from which no
appeal has been taken. 
 ARTICLE II – GRANT OF LICENSE 
 A. Grant of License. 
 As of the Effective Date of this Agreement, EPRO hereby grants to Spectrum
during the term of this Agreement and subject to the terms hereof, 
  

	 	(1)	 an exclusive license (even as to EPRO) to use the Documents and a non-exclusive license under the Licensed Technology to develop, 

  

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 Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission.
Confidential treatment has been requested with respect to the omitted portions. 

	 	 
make, have made, use, sell and have sold a Licensed Product in the Field of Use in the Territory; 

  

	 	(2)	the right to grant to Sublicensees, a sublicense under the Documents and the Licensed Technology licensed by subparagraph (1) of this Article II (A) of no greater scope
than the license granted hereunder to Spectrum, provided that party shall have agreed with Spectrum to be bound by the terms of this Agreement insofar as they relate to the operations of that party. 

  

	 	(3)	EPRO agrees not to grant any further licenses under the Documents and the Licensed Technology to Third Parties in the Field of Use in the Territory. 

 B. Improvements that are made by an employee, agent or consultant of Spectrum, solely or jointly with a Third Party, shall be owned by Spectrum.
Improvements that are made by an employee, agent or consultant of EPRO, solely or jointly with a Third Party, shall be owned by EPRO. Improvements that are made jointly by employees, agents or consultants of Spectrum and EPRO and its employees,
agents or consultants (“Joint Inventions”) shall be jointly owned by Spectrum and EPRO and treated as joint inventions under U.S. laws applicable to joint inventions. EPRO shall, and hereby does, grant Spectrum the exclusive and
unrestricted right in the Field of Use in the Territory to make, have made, use, sell, have sold, import, export and license EPRO’s interest in all Joint Inventions. EPRO hereby grants to Spectrum the exclusive and unrestricted right in
the Field of Use to make, have made, use, sell, have sold, import, export and license all Improvements made solely by EPRO, its employees or consultants in accordance with the provisions of the present Agreement. Spectrum hereby grants to EPRO the
exclusive and unrestricted right in the Field of Use outside the Territory and/or outside the Field of Use in or outside the Territory to make, have made, use, sell, have sold, import, export and license Spectrum’s improvements and interest in
all Joint Inventions, subject to the provisions of Article II (D) of this Agreement under commercially reasonable conditions to be negotiated in good faith between the parties which conditions shall be similar to those contained in this
Agreement. In addition, the Parties agree to negotiate in good faith the terms of a license agreement governing EPRO’s use of such Improvements and Joint Inventions. EPRO shall, and hereby does, after Spectrum’s royalty obligations under
Article V (A)(2) have expired or been terminated by Spectrum due to a breach of this Agreement by EPRO or due to the insolvency of EPRO pursuant to Article IX, grant Spectrum a perpetual, royalty-free license to use all Improvements owned by EPRO
and all information, know-how and other data pertaining to all Improvements and the Joint Inventions. Spectrum shall own any trademarks associated with the Licensed Products that it creates. 
 C. To the extent that EPRO has granted or, during the term of this Agreement until acceptance of Phase IV data by regulatory agencies, grants, a license
under the Licensed Technology to make, have made, use and sell the Licensed Product 
  

 5 

 
in the Field of Use outside the Territory to any Third Party, EPRO shall require such Third Party licensee(s) to promptly forward any and all safety data
obtained by any such Third Party pursuant to such license to Spectrum for it to use in its Phase IV clinical trials. Spectrum will treat such data as confidential in accordance with Article III (B) herein and, upon written request by EPRO, will
return such data to EPRO upon acceptance of Phase IV data by regulatory agencies. 
 D. EPRO shall have the right to license the Licensed
Technology to a Third Party or Third Parties for use outside the Field of Use in the Territory or develop the Licensed Technology itself to market a Product for use outside the Field of Use in the Territory; provided, however, that EPRO shall first
give an opportunity to Spectrum for an exclusive license under the Licensed Technology to manufacture, have manufactured, use and sell Licensed Product outside the Field of Use in the Territory using Levofolinic Acid as either the free acid or in
any salt form through a right of final negotiation to be completed not later than three (3) months after the date of receipt by Spectrum of written notice from EPRO of such an opportunity. Both Parties agree to negotiate in good faith to reach
such an agreement. 
 E. Manufacturing Information. 
 EPRO shall disclose all information it owns, or has the right to disclose to Spectrum to enable Spectrum to manufacture and use Licensed Products. This information shall include complete details of the manufacturing
process to produce Licensed Product in finished form. 
 F. Non-Assert Provision. 
 EPRO will not, 
  

	 	(1)	assert any of the Licensed Patents to prevent the use or sale of the Licensed Product in the Territory by any Third Party obtaining Licensed Product from Spectrum (for purposes of
this Article II (F), the term “Spectrum” shall include Third Parties used by Spectrum to market the Licensed Product), its Affiliate or by a Sublicensee; nor 

  

	 	(2)	assert any other patent or patent application now or hereafter controlled (in the sense of having the right to grant licenses or sublicenses) by EPRO to the Licensed Technology to
prevent any party obtaining Licensed Product from Spectrum, its Affiliate or a Sublicensee from using or selling any Licensed Product. 

 G. EPRO shall during the initial Regulatory Exclusivity Period not introduce, market or sell in the Territory any product which would be a substitute for Leucovorin and that directly competes with a Licensed Product.
Notwithstanding the foregoing, 
  

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EPRO shall be able to manufacture and/or supply a product that competes with a Licensed Product to a Third Party. For the avoidance of doubt, it is
acknowledged, that this paragraph shall not bind any other company of the Merck Group, to which EPRO belongs. 
 H. EPRO shall not take any
action against the *** in connection with the patents listed in Schedule A of the *** the result of which causes Spectrum to lose its exclusive license to such patents. 
 ARTICLE III – TECHNICAL INFORMATION AND CONFIDENTIALITY 
 A. Information to be
Transmitted. 
 EPRO shall, upon the Effective Date of this Agreement, deliver to Spectrum any Licensed Know-How necessary for Spectrum to
fulfill its obligations pursuant to Article VI(A). 
 B. Confidentiality. 
 The terms of that certain Mutual Confidentiality Agreement by and between the Parties, dated November 1, 2005, (to the extent such Mutual
Confidentiality Agreement is not inconsistent with this Agreement) shall be in addition to the provisions of this subsection. The Parties contemplate that during the course of their relationship it may be necessary to provide the other with
Confidential Information to facilitate the performance of their obligations pursuant to this Agreement. Confidential Information received from the disclosing Party which is in writing and identified as confidential or, if disclosed orally, is
summarized in writing and designated confidential, shall be maintained in confidence and that reasonable and prudent practices shall be followed to maintain the information in confidence including, where necessary, obtaining written confidentiality
agreements from employees not already bound by such agreements who have access to the Confidential Information. Confidential Information shall be used by a Party only for the purpose of and in connection with its performance under this Agreement.
The obligation to maintain information in confidence shall survive this Agreement or termination thereof for any reason for a period of seven (7) years thereafter. However, the obligations of nondisclosure and limited use shall not apply to
information which can be shown by written documentation: 
  

	 	i.	to have been publicly known prior to disclosure by the disclosing Party to the receiving Party; or 

  

	 	ii.	to have been known or available to the receiving Party prior to disclosure by the disclosing Party as shown by its prior written records; or 

  

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 Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission.
Confidential treatment has been requested with respect to the omitted portions. 

	 	iii.	to have become publicly known, without fault on part of the receiving Party, subsequent to disclosure by the disclosing Party; or 

  

	 	iv.	to have been received by the receiving Party from a Third Party legally having possession of the information without obligations of confidentiality; or 

  

	 	v.	to have been independently developed by or for the receiving Party without reliance on information received from the disclosing Party; or 

  

	 	vi.	to be required to be disclosed pursuant to order of any court or governmental agency having jurisdiction thereof after notice to the disclosing Party sufficient to afford it an
opportunity to intervene in the proceeding where disclosure is required. 

 Confidential Information shall not be deemed to be
within the foregoing exceptions merely because it is embraced within broader or general disclosures known to the public or the recipient Party, and any combination of features shall not be deemed to be within the foregoing exceptions merely because
individual features are known to the public or to the recipient unless the whole combination of features and its principle of operation are known. 
 ARTICLE IV – REPRESENTATIONS, WARRANTIES AND INDEMNIFICATION 
 A. Mutual Representations. Each of the Parties
represents and warrants that: 
  

	 	(a)	It is a corporation or entity duly organized and validly existing under the laws of the state or other jurisdiction of its incorporation or formation. 

  

	 	(b)	The execution, delivery and performance of this Agreement by such Party have been duly authorized by all requisite corporate action. 

  

	 	(c)	It has the power and authority to execute and deliver this Agreement and perform its obligations hereunder and thereunder. 

  

	 	(d)	 The execution, delivery and performance by such Party of this Agreement does not and will not conflict with or result in breach of the terms and provisions of any
other agreement or constitute a default under (i) a loan agreement, guaranty, financing agreement, 

  

 8 

	 	 
affecting a product or other agreement or instrument binding or affecting it or its property; (ii) the provisions of its charter or operative documents
or bylaws; or (iii) any order, writ, injunction or decree of any court or governmental authority entered against it or by which any of its property is bound. 

  

	 	(e)	The execution, delivery and performance of this Agreement by such Party does not require the consent, approval or authorization of, or notice, declaration, filing or registration
with, any governmental or regulatory authority in the Territory and the execution, delivery and performance of this Agreement does not violate any law, rule or regulation applicable to such Party. Notwithstanding the foregoing, Spectrum may be
required to file notices with the necessary regulatory authorities to notify them of Spectrum’s ownership of the regulatory filings described in Article VI (A) (3). 

  

	 	(f)	This Agreement has been duly authorized, executed and delivered and constitutes such Party’s legal, valid, and binding obligation enforceable against it in accordance with
their terms subject, as to enforcement, to bankruptcy, insolvency, reorganization and other laws of general applicability relating to or affecting creditors’ rights and to the availability of particular remedies under general equity principles.

  

	 	(g)	It shall comply with all applicable laws and regulations relating to its activities under this Agreement. 

  

	 	(h)	It is not debarred and has not and will not use in any capacity the services of any person debarred under subsections 306 (a) and (b), of the Generic Drug Enforcement Act of
1992. If at any time during the term of this Agreement this warranty is no longer accurate, the affected Party shall immediately notify the other and the Parties shall negotiate to resolve issues that may affect Spectrum’s ability to
manufacture, have manufactured, use or sell Licensed Products. 

 B. EPRO Representations. 
 EPRO represents and warrants that, as of the Effective Date: (a) to the best of its knowledge, it is the owner of all right, title and interest in
and to the Licensed Technology; (b) it has not received any written notice and, to the best of its knowledge, operating under the Licensed Technology does not infringe the proprietary rights of any Third Party; (c) there are no claims,
judgments or settlements against or owed by EPRO, or pending or threatened claims, or litigation, relating to the Licensed Technology; (d) to the best of its knowledge, Exhibit A is a complete and accurate listing of all patents and patent
applications subject to grant hereunder; (e) EPRO has not 

  

 9 

 
granted any right, license or interest in or to the Licensed Technology, or any portion thereof, inconsistent with the rights granted to Spectrum herein;
(f) to the best of its knowledge, no Third Party has any right or authority to prohibit Spectrum from using the Licensed Technology in the Territory in any way; and ***. 
 In the event an injunction is issued against Spectrum because of infringement of Third Party intellectual property rights, the parties will share
liability for Spectrum’s expenses. If the injunction is not dissolved within three (3) months after issuance, then Spectrum shall be solely responsible for its legal expenses in attempting to dissolve such injunction thereafter.

 C. Indemnification. 
 EPRO shall indemnify and hold Spectrum harmless from and against any liability, loss, cost, expense (including reasonable attorneys’ fees), damage, or penalty of any kind, on account of or resulting from (i) any breach by EPRO of
its representations and warranties contained in this Article IV, (ii) any breach by EPRO of any covenant contained in this Agreement, and (iii) any claim or action for infringement of any Third Party intellectual property rights as a
result of Spectrum’s operations under the Licensed Technology in the Territory in accordance with this Agreement claimed or issued before the Effective Date, ***. EPRO’s liability under this paragraph IV(C)(iii) shall be limited to the
amount of damages/royalties imposed on Spectrum by judgment or settlement upon the finding of infringement and shall be further limited to the amount of Fees (as hereinafter defined) paid by Spectrum to EPRO. EPRO shall have the right, at any time,
to join negotiations with a Third Party whose intellectual property rights are alleged to be infringed or to take over negotiations with that Third Party if the scope of the alleged infringement is outside the scope of Spectrum’s operations
under this Agreement. Any settlement of such alleged infringement shall be agreed to by both parties, which EPRO’s consent shall not be unreasonably withheld. 
 Spectrum shall indemnify EPRO and hold EPRO harmless from and against any liability, loss, cost, expense (including reasonable attorneys’ fees), damage, or penalty of any kind, on account of or resulting from
(i) any breach by Spectrum of its representations and warranties contained in this Article IV and (ii) any breach by Spectrum of any covenant contained in this Agreement. 
 ARTICLE V—PAYMENTS AND REPORTS 
 A. Fees. In consideration for the license granted
hereunder, Spectrum shall pay EPRO the following fees in U.S. Dollars (“Fees”): 
 (1) Up-Front and Progress Payments (all payments
are one-time payments): 
 (a) Within *** after NDA approval by the FDA for an ***, a progress payment of ***dollars ($***); 
  

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 (b) Within *** after NDA approval by the FDA of an ***, a progress payment of *** ($***). 
 (2) Royalties: 
 Spectrum shall pay EPRO, beginning with the first commercial sale of the Licensed Product in a particular country and expiring on the later of (a) the expiration of the last of the patents licensed hereunder issued in that country that
includes a Valid Claim that would, in the absence of the license granted hereunder, be infringed by the sale of a Licensed Product, or (b) the expiration of all Regulatory Exclusivity Periods with respect to the Licensed Product in such
country, royalties based on quantities of the Licensed Product sold by Spectrum, its Affiliates; and/or its Sublicensees in accordance with the following formula: 
 (a) *** percent (***%) of Net Sales of the Licensed Product for sales annually of up to and including *** dollars ($***); 
 (b) ***percent (*** %) of Net Sales of the Licensed Product for sales annually between *** dollars ($***) and up to and including *** dollars ($***); 
 (c) *** percent (***%) of Net Sales of the Licensed Product for sales annually between *** dollars ($***) and up to and including *** dollars ($***);

 (d) *** percent (*** %) of Net Sales of the Licensed Product for sales annually of over *** dollars ($***); 
 After Spectrum is no longer required to pay any royalty described under subparagraphs (a) through (d) above in a particular country in the
Territory, then Spectrum shall pay EPRO a royalty of *** (***%) percent of Net Sales of the Licensed Product in such country until a generic version of such Licensed Product is sold within such country. 
 (3) EPRO shall be responsible for any fees owed by Spectrum to the *** pursuant to Articles III (A) (1) & (2) of the ***. Therefore,
Spectrum shall be able to deduct from any payments owed to EPRO under Articles V (A) (1) & (2) of this Agreement, any amounts owed to the *** pursuant to Articles III (A) (1) & (2) of the ***. Information
regarding such deductions shall be included in the reports provided in 

  

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Article (V) (B) below. In addition, in the situation where Spectrum owes an amount to the *** pursuant to Articles III (A) (1) &
(2) of the ***, but Spectrum is unable to deduct it from a payment owed to EPRO, Spectrum shall provide EPRO with a report of such amount paid to the *** and EPRO shall pay Spectrum such amount within thirty (30) days. EPRO shall not be
responsible for any fees owed by Spectrum to the *** pursuant to Article III (A) (3) of the ***. 
 B. Reports and
Remittances. Until such time as Spectrum, its Affiliates, its Sublicensees have sold all quantities of the Licensed Product subject to fee hereunder, Spectrum shall report in writing to EPRO within *** after the end of *** the quantities of each
Licensed Product subject to fee hereunder that were sold by Spectrum, its Affiliates, its Sublicensees during said quarter and the calculation of the fees thereon. With said report Spectrum shall pay to EPRO the total amount of the said fees. If no
Licensed Product subject to fee hereunder has been sold by Spectrum, its Affiliates, any Sublicensees during any such period, Spectrum shall so report in writing to EPRO within *** after the end of such period. Reports, notices and other
communications to EPRO hereunder shall be sent to: 
 Merck Eprova AG 
 Im Laternenacker 5 
 8200 Schaffhausen 
 Switzerland 
 Attention: Martin Ulmann 
                   General Manager 
 Fax:__       ++41 (0)52 630 72 55_________________ 
 Each payment to EPRO hereunder shall be sent to EPRO under separate cover along with a copy of the relevant report to: 
 Merck Eprova AG 
 Im Laternenacker 5 
 8200 Schaffhausen 
 Switzerland 
 Attention: Martin Ulmann 
                   General Manager 
 Notices to Spectrum shall be sent to the address set forth above unless a different address is designated in writing by Spectrum. 
 C. Taxes. If laws, rules or regulations require withholding of income taxes or other rates imposed upon payments set forth in this Article V, Spectrum may make such withholding payments as required and subtract such withholding
payments from the payments set forth in this Article V. Spectrum shall submit appropriate proof of payment of the withholding rates to EPRO within a reasonable period of time. Spectrum shall use efforts consistent with its usual business practices
to ensure that any withholding 

  

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taxes imposed are reduced as far as possible under the provisions of the current or any future double taxation treaties or agreements between foreign
countries, and the Parties shall cooperate with each other with respect thereto, with the appropriate Party under the circumstances providing the documentation required under such treaty or agreement to claim benefits thereunder. 
 D. Records. Spectrum shall keep full, complete and proper records and accounts of all sales of Licensed Products by Spectrum, its Affiliates, and
to the extent it acquires rights to do so, its Sublicensees, in accordance with GAAP, in sufficient detail and in the currencies in which the sale was made to enable the royalties payable on each Licensed Product to be determined. All such records,
statements, reports and accounts referred to in this Article shall be retained for a period of three (3) years after the end of the period to which they apply. 
 E. Audit. If EPRO disagrees with a report provided by Spectrum, pursuant to Article V (B), EPRO, at its own expense, shall have the right, upon reasonable prior notice during regular business hours, to meet
with Spectrum’s independent auditor to inspect and discuss the books and accounts of Spectrum or its Affiliates, related to the payment and calculation of royalties arising under this Agreement. After this inspection, if EPRO still disagrees
with the report provided by Spectrum, with reasonable justification for such disagreement, EPRO, at its own expense, shall have the right, upon reasonable prior notice during regular business hours, to appoint independent auditors reasonably
acceptable to Spectrum and have them during normal business hours, inspect the books and accounts of Spectrum or its Affiliates, related to the payment and calculation of royalties arising under this Agreement. Spectrum shall cooperate and cause
Spectrum’s Affiliates, to cooperate with such auditors. The auditors performing the audit shall disclose to EPRO only information relating to the accuracy of records kept and the payments made, and shall be under a duty to keep confidential any
other information obtained from such records. If any such audit establishes that Spectrum has underpaid or overpaid the amount due, Spectrum shall promptly pay any remaining amounts due as established by such audit or EPRO shall promptly refund any
over payment. If the underpayment is by *** percent (***%) or more during any ***, Spectrum shall reimburse EPRO for the reasonable expenses of such audit. 
 ARTICLE VI – SPECTRUM DELIVERABLES 
 A. Government Approvals. 
  

	 	(1)	 In consideration for the licenses granted hereunder, Spectrum, at its cost and expense, shall use commercially reasonable efforts to complete, file and actively
pursue an NDA for one or more Licensed Products in the Territory. Spectrum shall use its commercially reasonable efforts to file a reasonable response to the most recent 

  

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deficiency letter from the FDA for the NDA for the use of a Licensed Product for injection for methotrexate rescue within *** after signing of this
Agreement. 

  

	 	(2)	The Parties shall form a committee with two (2) representatives each from both Parties in order to provide a forum whereby Spectrum can regularly update EPRO on the progress in
developing the Licensed Product(s). 

  

	 	(3)	Any and all registrations and/or regulatory filings with the FDA or other appropriate regulatory agency in the Territory for the Licensed Products in the Field of Use will be filed
in the name of Spectrum as the sponsor of the NDA or other appropriate registration in the Territory and shall be owned by Spectrum. In addition, any registrations and/or regulatory filings that have been previously filed shall be transferred and
placed in the name of Spectrum and shall be owned by Spectrum. 

  

	 	(4)	It is the parties’ expectation that EPRO shall be permitted to make reference to and utilize the technical, manufacturing, safety and efficacy clinical data included in
Spectrum’s application for the development and use of, and regulatory approval for, the manufacture, use and sale of Licensed Product except where such use of data would derogate from Spectrum’s exclusive rights in the Field of Use in the
Territory. EPRO shall also be permitted such use of data outside the Field of Use in the Territory under the conditions described in the preceding sentence with the proviso that EPRO obtains Spectrum’s prior written consent and subject
to Article II (D) of this Agreement. 

 B. Product Marketing. Spectrum will, at its expense and upon approval of
the NDA for the Licensed Product, begin marketing efforts in the Territory to promote and sell the Licensed Product, and will provide EPRO marketing plans to that end on an *** basis. 
 C. Spectrum Efforts. Spectrum, its Affiliates, and/or its Sublicensees shall perform their obligations under the Agreement by expending their
commercially reasonable efforts by exercising the same level of effort to promote, advertise and market Licensed Product as they expend for their other respective products with similar sales potential. 
 D. Non-Competition. Spectrum, and its Sublicensees will not, for a period of *** from the first commercial sale of the Licensed Product, as long
as the Agreement is in effect, introduce, market or sell in the Territory and in the same Field of Use any new 

  

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product which is an isomeric form of leucovorin. 
 ARTICLE
VII – INTELLECTUAL PROPERTY 
 A. Trademarks. EPRO shall have the right, in its sole discretion and at its own expense, to
select and register such trademarks as it wishes to employ in connection with the sale of the Licensed Product outside the Field of Use throughout the Territory and EPRO shall have legal and equitable ownership of the entire right, title and
interest in and to the trademarks and registrations EPRO elects to use. In the event that any trademarks applications are filed or registrations issued, EPRO hereby grants to Spectrum, for the term of this Agreement, a non-exclusive license to use
such trademarks in connection with the promotion and sale of the Licensed Product in the Field of Use. 
 B. Prosecution of Patents.
EPRO shall be solely responsible for preparing, prosecuting and maintaining the Licensed Patents, including payment of all necessary filing and maintenance fees. 
 (a) Each Party shall cooperate with the other Party to execute all required papers and instruments and to make all required oaths and declarations as may be necessary in the preparation and prosecution of all such
patents and other applications and protections referred to in this Article. 
 (b) In the event that EPRO wishes to abandon any patent within
the Licensed Patents, EPRO will offer to assign to Spectrum, free of charge, any such patent prior to effectuating the abandonment. Spectrum shall bear the costs connected with any assignment, and recordation thereof, hereunder. 
 ARTICLE VIII – ABATEMENT OF INFRINGEMENT 
 A. If
at any time any Third Party shall infringe to a commercially substantial extent any patent licensed hereunder then Spectrum shall promptly inform EPRO of such infringement and EPRO shall, subject to Paragraph (C) of this Article, either
(a) obtain a discontinuance of said infringing operations or (b) bring suit at its own expense against such infringer, bringing said suit in the name of EPRO and, if so required by the law of the forum, bringing suit in the name of
Spectrum or joining Spectrum as a party plaintiff with EPRO. In such an event and until EPRO effectuates discontinuance of infringement, Spectrum’s applicable royalty rates shall be reduced to ***. Upon discontinuance of such infringement,
Spectrum shall resume paying royalties at the rates indicated in Article V(A)(2). EPRO shall be entitled to receive and retain all recoveries from such infringement. 
  

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 B. Spectrum shall have the right, in any suit brought by EPRO pursuant to paragraph (A) of this
Article, to be represented at its own expense by counsel of its own selection to the extent of having access to full information and opportunity to be heard in the councils of EPRO. 
 C. In the event that EPRO neither brings suit against a Third Party as provided in paragraph (A) of this Article nor obtains a discontinuance of
such infringing operations within six (6) months of the date of receipt of such notice, then Spectrum may at its election bring suit in its own name against such infringer. Should Spectrum bring suit in its own name, EPRO shall execute such
legal papers necessary for the prosecution of such suit as may be requested by Spectrum, and Spectrum shall be liable for all costs and expenses of such litigation and shall be entitled to receive and retain all recoveries therefrom. During the
pendency of such suit by Spectrum, and in the event of an adverse outcome of such suit, Spectrum’s royalty obligations shall be reduced as indicated in paragraph (A) of this Article or eliminated in the latter case. 
 D. If a Third Party makes or threatens against Spectrum, its Affiliates or its Sublicensees any claim of infringement of a patent right based upon the
use of, or arising as a result of the exercise of the rights and licenses granted hereunder to the Licensed Technology (each an “Alleged Infringement”), Spectrum shall have the right to respond to and defend any and all such Alleged
Infringements at its own cost and expense, and in its sole discretion. EPRO agrees to provide any necessary assistance that Spectrum may reasonably require in any such defense action for which Spectrum shall pay to EPRO a reasonable hourly rate of
compensation. EPRO shall have the right, at its own expense, to retain counsel of its choice to represent it in any such defense action. Spectrum shall notify EPRO in writing and provide a copy of (i) any claim of Alleged Infringement filed
with a court or governmental authority or (ii) any written notice of an Alleged Infringement from an attorney or law firm. Within a reasonable period of time in advance of any responsive deadline required by law or otherwise set forth in the
claim or notice of Alleged Infringement, Spectrum shall notify EPRO in writing as to whether or not Spectrum intends to respond to such Alleged Infringement. In the event that Spectrum does not intend to respond to any such claim or notice or, if
Spectrum, in its sole discretion, asks EPRO to respond to any such claim or notice, EPRO shall have the right, in its sole discretion, to respond to and litigate or settle such Alleged Infringement, in which case EPRO shall pay any and all future
costs and expenses incurred by Spectrum in such action, and shall indemnify, defend and hold Spectrum, its Affiliates and its Sublicensees harmless from any future costs, expenses or liability respecting all such actions undertaken by EPRO. This
Article VIII (D) shall not amend or reduce EPRO’s indemnification obligations under Article IV (C). 
 ARTICLE IX – TERMINATION

 A. Termination. Unless terminated early in accordance with the provisions of this Agreement, the term of this Agreement shall
endure on a Licensed Product-by- 

  

 16 

 
Licensed Product and country-by-country basis until the expiration of the obligation to pay royalties under Article V (A) (2) above applicable to
such Licensed Product in such country. This Agreement shall expire in its entirety after the date that Spectrum no longer owes any royalties to EPRO under Article V (A) (2). 
 B. Early Termination by Spectrum. Spectrum shall have the unilateral right to terminate this Agreement, in its entirety or on a Licensed
Product-by-Licensed Product or country-by-country basis, at any time for any reason upon prior written notice to EPRO given at least *** prior to the desired termination. 
 C. Early Termination by EPRO. EPRO shall have the unilateral right to terminate this Agreement, in its entirety upon prior written notice to Spectrum if Spectrum has failed to comply with the obligations laid
down in ***. 
 D. Termination upon Breach. In the event that any stipulation or provision of this Agreement is materially breached by
a Party, the other Party may terminate this Agreement upon *** written notice to the breaching party. However, if such breach is corrected within the *** period, and there are no unreimbursed damages resulting from the breach, this Agreement shall
continue in force. A material breach by Spectrum of its obligations under Article VI (A) (1) shall be governed by Article IX (C). 
 E. Insolvency. Should a Party (1) become insolvent or unable to pay its debts as they mature, (2) make an assignment for the benefit of creditors, (3) permit or procure the appointment of a receiver for its assets, or
(4) become the subject of any bankruptcy, insolvency or similar proceeding, then the other Party may at any time thereafter on written notice to the insolvent Party, effective forthwith, cancel this Agreement. 
 F. Effect of Termination. 
  

	 	(1)	Upon termination of this Agreement pursuant to Article IX (A), the licenses granted hereunder shall be considered fully-paid and Spectrum and its Sublicensees shall be free to
continue to use the Licensed Technology and Documents to make, use and sell the Licensed Products without further financial obligations to EPRO hereunder. Other than rights intended to survive expiration, or royalties or fees that accrued during the
term of the Agreement in accordance with Article V (A) (2), neither Party shall have any further rights or obligations upon the expiration of this Agreement. 

  

	 	(2)	 Upon termination of this Agreement by EPRO pursuant to Articles IX (C), (D) or (E), or by Spectrum pursuant to Article IX (B), occurring prior to the regularly
scheduled expiration date of this Agreement, (i) all rights and licenses granted by EPRO to Spectrum including any rights to the Licensed Product shall terminate and 

  

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revert to EPRO and (ii) Spectrum shall return to EPRO or destroy at EPRO’ option all copies of the Licensed Know-How. The foregoing provisions
shall also apply to the partial termination of this Agreement by Spectrum in accordance with Article IX (B), provided, however, that in such event: (1) only those rights that solely pertain to the Licensed Product and/or country being
terminated would revert back to EPRO; (2) only copies of the Licensed Know-How that solely pertain to the Licensed Product and/or country being terminated would be returned or destroyed by Spectrum. Notwithstanding the foregoing, Spectrum shall
retain its right, title and interest under Article II (B) in any Improvements made solely by Spectrum and in any Joint Inventions. 

  

	 	(3)	Upon any termination of this Agreement by Spectrum under Articles IX (D) or (E) occurring prior to the regularly scheduled expiration date of this Agreement, the license
rights granted by EPRO to Spectrum contained in this Agreement shall continue in full force and effect, however, Spectrum’s obligations under this Agreement to pay royalties shall terminate. 

 G. Obligations of the Parties. The obligations of the Parties under Articles II (F), III (B), IV(C), V (A) (3), IX (F) & (G), and
Articles VIII, XI, XIII and XV and any other provisions which are expressly indicated to survive expiration or termination, shall remain in effect upon any termination or expiration of this Agreement as shall Spectrum’s obligations under
Articles V (A) (2) (a)—(d) for Licensed Products sold prior to such termination or expiration. 
 ARTICLE X – ASSIGNABILITY

 Except for sublicensing rights as set forth in Article II (A) (2), this Agreement shall not be assignable in whole or part to any
Third Party without the prior written consent of the other Party (such consent not to be unreasonably withheld), except, to a successor in interest pursuant to a merger, acquisition or sale of all or substantially all of the assignor’s assets
to which this Agreement relates. Any attempted assignment in violation of this provision shall be null and void. 
 ARTICLE XI – APPLICABLE LAW

 This Agreement is acknowledged to have been made in and shall be construed in accordance with the laws of Switzerland without regard to
the principles thereof relating to the conflict of laws; provided that all questions concerning the construction or effect of patent applications and patents shall be decided in accordance with the laws of 

  

 18 

 
the country in which the particular patent application or patent concerned has been filed or granted, as the case may be. 
 ARTICLE XII – FORCE MAJEURE 
 Neither Party shall
be responsible to the other for delay or failure in performance of any of the obligations imposed by this Agreement, provided such delay or failure shall be occasioned by a cause beyond the control of and without the fault or negligence of such
Party, including fire, flood, explosion, lightning, windstorm, earthquake, subsidence of soil, failure of machinery or equipment or supply of materials, discontinuity in the supply of power, court order or governmental interference, civil commotion,
riot, war, terrorism or terroristic threats, strikes, labor disturbances, transportation difficulties or labor shortage. Notwithstanding the aforesaid, if either Party fails to a substantial extent for at least *** to fulfill any of its obligations
under this Agreement, the other Party may terminate the Agreement. 
 ARTICLE XIII – DISPUTE RESOLUTION 
 In the event that a dispute arises between the Parties, the following procedures shall be followed: 
 A. Negotiations. In the event that any dispute may arise, the Parties shall first seek to resolve any disputes by negotiation among senior
executives who have authority to settle the controversy, as follows: 
  

	 	(a)	Notification. When a Party believes there is a dispute relating to the Agreement, the Party will give the other Party written notice of the dispute. 

 

	 	(b)	Meeting Among Senior Executives. The senior executives shall meet at a mutually acceptable time and place within thirty (30) days after the date of the notice to
exchange relevant information and to attempt to resolve the dispute. 

  

	 	(c)	Confidentiality. All negotiations are confidential, shall be treated as compromise and settlement negotiations, and neither party shall use information obtained during such
negotiations in any subsequent dispute resolution proceeding. 

 B. Mediation. If the dispute has not been resolved
within thirty (30) days after the date of the notice of a dispute, or if the Party receiving such notice fails or refuses to meet within such time period, either Party may initiate mediation of the dispute by 

  

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sending the other Party a written request that the dispute be mediated. The Party receiving such a written request will promptly respond to the requesting
Party so that both Parties can jointly select a neutral and impartial mediator and schedule the mediation session. The Parties shall mediate the dispute before a neutral, third-party mediator within thirty (30) days after the date of the
written request for mediation. 
 C. Arbitration. Any controversy or claim arising out of or relating to this Agreement or the breach
thereof, and not settled as described in Article XIII (A) or (B), shall be settled by arbitration in accordance with the Licensing Agreement Arbitration Rules of the International Chamber of Commerce, utilizing the laws of Switzerland, without
giving effect to its conflicts of laws rules, and judgment upon the award rendered by the Arbitrator(s) may be entered in any Court having jurisdiction thereof. The situs of arbitration shall be Schaffhausen, Switzerland if initiated by Spectrum and
Irvine, California if initiated by EPRO. 
 ARTICLE XIV – ADJUDICATION OF LICENSED PATENTS 
 Should any Licensed Patents be declared invalid or not infringed or limited in scope by a final decision (from which no appeal is or can be taken) of a
court or other tribunal of competent jurisdiction in the country in which said patent was granted, then the construction placed upon the patent by said court or other tribunal shall be followed by the Parties from and after the date of entry of the
decree of said court or tribunal and fees shall thereafter be payable to EPRO only in accordance with such construction. 
 ARTICLE XV –
MISCELLANEOUS PROVISIONS 
 A. The rights and remedies provided in this Agreement are cumulative and not exclusive of any rights or
remedies provided by law or in equity. 
 B. Except as required by law or the rules of the principal stock exchange on which the Party’s
stock is traded, no Party shall originate any public statement, news release or other written public announcement, whether in the public press, stockholders’ reports, or otherwise, relating to this Agreement or to any sublicense hereunder, or
to the performance hereunder or any such agreements, or use a Party’s name for any purpose, including, without limitation, in connection with the advertising or sale of Licensed Products, without the prior written approval of the other Party,
such consent not to be unreasonably withheld. The Parties each agree to respond to each such request within five (5) business days of receipt of a request (unless a shorter period of time is necessary to comply with law). Notwithstanding
anything to the contrary in this Agreement, each party shall be permitted to publicly disclose (i) the existence of this Agreement, (ii) that EPRO and Spectrum are the parties to this Agreement, and (iii) the Licensed Technology
covered by this Agreement. In the case of unintentional public 

  

 20 

 
disclosure concerning this Agreement, any Licensed Product or any other subject matter hereof, the disclosing Party shall promptly inform the other Party of
such disclosure and the other Party shall be entitled to make a public announcement regarding the subject matter of the disclosure. The other Party shall notify the disclosing Party of their intention to make such an announcement. Following a
Party’s consent to or approval of the public announcement of any information pursuant to this Article, both Parties shall be entitled to make subsequent public announcements of such information without renewed compliance with this Article,
unless the scope and/or duration of such consent or approval is expressly limited. 
 C. This Agreement embodies the entire understanding of
the Parties and shall supersede all previous communications, representations, undertakings or agreements, between them, either verbal or written, relating to the subject matter hereof. 
 D. This Agreement shall be binding upon and enure to the benefit of the successors, permitted assignees and personal representatives of the Parties.

 E. In the event that any one or more of the provisions contained in this Agreement shall for any reason be held to be invalid, illegal or
unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provision hereof, and this Agreement shall be construed as if such invalid, illegal or unenforceable provisions or provisions had never been
contained herein. 
 [SIGNATURE PAGE FOLLOWS] 
  

 21 

 IN WITNESS WHEREOF, the Parties have executed this Agreement and have entered the Effective Date
on the first page hereof. 
  

									
		 		 	Merck Eprova AG
					
	By 	 	 /s/ Thomas Suter
	 		 	By 	 	 /s/ Martin Ulmann

					
	Title	 	 Chief Financial Officer
	 		 	Title	 	 General Manager

					
	Date	 	 June 1, 2006
	 		 	Date	 	 June 1, 2006

  

									
		 		 	Spectrum Pharmaceuticals, Inc.
					
		 		 		 	By 	 	 /s/ Rajesh C. Shrotriya, M.D.

		 		 		 		 	Rajesh C. Shrotriya, M.D.
					
		 		 		 	Title	 	 Chairman, CEO & President

					
		 		 		 	Date	 	 May 19, 2006

  

 22 

 EXHIBIT A 
  

					
	 Country
	 	 Patent No.
 (Patent Application No.)
	 	 Normal
 Expiry Date
 (Filing Date)

 *** 
  

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Confidential treatment has been requested with respect to the omitted portions. 

 EXHIBIT B 
 *** 
  

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Confidential treatment has been requested with respect to the omitted portions.

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