Document:

imra-ex104_233.htm

Exhibit 10.4

 

IMARA Inc.

116 Huntington Avenue, 6th Floor

Boston, MA 02116 USA

 

Info@Imaratx.com

+1 617 202-2020

 

www.imaratx.com

 

May 18, 2022

 

Michael P. Gray

 

Dear Mike,

 

You are a key member of the senior management team of Imara Inc. (the “Company”).  As a result, subject to the terms and conditions of this letter agreement, you will be eligible for the following retention benefits should you remain employed by the Company through the specified milestones set forth herein.  This letter agreement shall amend and restate in its entirety that certain letter agreement, dated May 5, 2022 (the “May 5 Agreement”), between you and the Company and the retention benefits provided herein shall replace any such retention benefits provided in the May 5 Agreement.

 

	
 
	
1.
	
Cash Retention. You will be eligible to receive cash retention payments totaling up to $109,756 (the “Potential Retention Amount”), to be payable, if at all, as follows:

 

•50% of the Potential Retention Amount ($54,878) will be payable if you remain employed by the Company through execution of an agreement providing for the merger or consolidation of the Company (or a wholly owned subsidiary of the Company) with a non-affiliate third-party (the “Merger Transaction”); and

•50% of the Potential Retention Amount ($54,878) will be payable if you remain employed by the Company on the date of the closing of the Merger Transaction.

The Company will pay any portion of the Potential Retention Amount that becomes payable, less all applicable taxes and withholdings, as a lump sum payment on the first regularly scheduled payroll date following the date on which such portion of the Potential Retention Amount becomes payable.  If you cease to be employed by the Company for any reason prior to the date on which any portion of the Potential Retention Amount becomes payable, then you will not be eligible to receive such portion(s) of the Potential Retention Amount.

	
 
	
2.
	
Modification to Options.  In addition, if you remain employed by the Company on the date of the closing of the Merger Transaction, then each stock option agreement between you and the Company that (i) is outstanding on the date hereof and (ii) provides for stock options to purchase shares of Common Stock of the Company at a purchase price of less than $5.00 per share (each an “Applicable Stock Option”), shall be modified to provide that the period during which you may exercise the vested portion of each such Applicable Stock Option shall be extended until the date that is the earlier of (a) eighteen months following your cessation of 

 

 

	
 
		
employment from the Company and (b) the final exercise date for each such Applicable Stock Option.  A schedule of the Applicable Stock Options is set forth on Exhibit A.

 

	
 
	
3.
	
Prior Agreements. This letter agreement constitutes the entire agreement of the parties with regard to its subject matter, and supersedes all previous written or oral representations, agreements and understandings between the parties with regard to such subject matter.  Notwithstanding the foregoing, and for the avoidance of doubt, nothing herein supersedes that certain (i) letter agreement, dated September 23, 2019, as amended November 5, 2021 between you and the Company and governing the terms of your employment or (ii) Employee Confidentiality, Assignment and Noncompetition Agreement signed by you on March 26, 2019.  Additionally, except as provided in Section 2 herein, each stock option agreement or restricted stock unit agreement with respect to outstanding awards made under the Employer’s 2016 Stock Incentive Plan or 2020 Equity Incentive Plan remains in full force and effect in accordance with its terms.

 

	
 
	
4.
	
Amendment.  No provision of this letter agreement may be modified, waived or discharged unless such waiver, modification or discharge is agreed to in writing and signed by you and an authorized officer of the Company designated by the Board of Directors of the Company (other than you).  No waiver by either party hereto at any time of any breach by the other party hereto of, or compliance with, any condition or provision of this letter agreement to be performed by such other party shall be deemed a waiver of similar or dissimilar provisions or conditions at the same or at any prior or subsequent time

 

	
 
	
5.
	
Counterparts.  This letter agreement may be executed in any number of counterparts, each of which shall be deemed an original and all of which taken together shall be deemed to constitute one and the same instrument.  An executed signature page of this letter agreement delivered by facsimile transmission (with transmission confirmed) or in .pdf format via e-mail shall be as effective as an original executed signature page.

 

2

 

 

 

Please accept all of the terms as set forth herein by signing and returning this letter agreement.

 

Sincerely,

			
	
IMARA INC.
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
By:
	
/s/ Rahul Ballal
	
 

	
Name:
	
Rahul D. Ballal, Ph.D.
	
 

	
Title:
	
President and CEO
	
 

	
 
	
 
	
 

 

 

 

 

 

 

 

 

 

		
	
AGREED:

	
 
	
 

	
 
	
 

	
By:
	
/s/ Michael P. Gray

	
Name:
	
Michael P. Gray

 

3

 

 

 

Exhibit A

 

Applicable Stock Options

				
	
Grant Date
	
Plan/Type
	
Granted Shares
	
Exercise Price

	
05/16/2019
	
2016/ISO
	
81,300 
	
$4.92 

	
05/16/2019
	
2016/NQ
	
143,009 
	
$4.92 

	
05/16/2019
	
2016/NQ
	
35,676 
	
$4.92 

	
05/16/2019
	
2016/ISO
	
2,379 
	
$4.92 

	
01/28/2022
	
2020/NQ
	
27,049 
	
$1.38 

	
01/28/2022
	
2020/ISO
	
12,301 
	
$1.38 

 

4EX-10.2

   

   Exhibit 10.2

   

  [***] = INFORMATION HAS BEEN OMITTED BECAUSE IT IS BOTH NOT MATERIAL AND IS THE TYPE OF INFORMATION THAT ARCUS BIOSCIENCES, INC. TREATS AS PRIVATE OR CONFIDENTIAL

   

   

  July 1, 2022

   

  Arcus Biosciences, Inc. 
3928 Point Eden Way

  Hayward, CA 94545

  Attention: General Counsel 

   

  Re:  Collaboration on Gilead’s CD73 program  

   

  Dear Ladies and Gentlemen:

   

  The letter agreement (“Letter Agreement”) makes reference to that certain Option, License and Collaboration Agreement (the “OLCA”), entered into as of May 27, 2020, as amended November 17, 2021, by and between Arcus Biosciences, Inc. (“Arcus”) and Gilead Sciences, Inc. (“Gilead”).  Gilead and Arcus are referred to herein individually as a “Party” and collectively as “Parties.”  Capitalized terms used and not otherwise defined herein shall have the meanings given such terms in the OLCA to the extent defined therein.  

   

  As of the Option Exercise Closing for the CD73 Program (the “Arcus CD73 Program”), Gilead and Arcus are and have been collaborating on, among other things, the Development of the Arcus CD73 Program pursuant to the OLCA.  Separately, Gilead has been developing its own internal program Directed To CD73 (the “Gilead CD73 Program”), which, for clarity, has been developed by Gilead outside of the Arcus CD73 Program being Developed by the Parties under the OLCA.  The Parties now desire to collaborate on the Gilead CD73 Program (and continue to collaborate on the Arcus CD73 Program) in order to advance the development of each Party’s compounds and products Directed To CD73 on the terms and conditions set forth herein, and the Parties hereby agree as follows:

   

  1.As of the date hereof, the Gilead CD73 Program shall be deemed an “Optioned Program” under the OLCA for all purposes, except as otherwise expressly set forth herein.  The date hereof shall be deemed the date of Option Exercise Closing for the Gilead CD73 Program.  For the avoidance of doubt, (a) the Parties’ collaboration with respect to the Gilead CD73 Program under the OLCA shall be separate and in addition to the Parties’ collaboration with respect to the Arcus CD73 Program under the OLCA and (b) the Gilead CD73 Program and the Arcus CD73 Program each constitutes a separate Optioned Program under the OLCA.

  2.Gilead shall be solely responsible, in its discretion and at its sole cost and expense, for conducting all Development activities with respect to the Gilead CD73 Program [***] on the lead Molecule included in such Gilead CD73 Program [***].  Upon reaching [***], Gilead shall not proceed with any clinical Development activities unless and until the JSC has approved initiation of further Development of the Gilead CD73 Program (“Clinical Initiation”), as further described below.  Unless and until the JSC has approved the Clinical Initiation, Gilead shall not be obligated under 

  1

  

   

  Section 4.2 of the OCLA to [***] to Develop and obtain Regulatory Approval for [***].  From and after the date on which the JSC approves the Clinical Initiation, Gilead shall [***] to Develop and obtain Regulatory Approval [***].

  3.The JSC shall have responsibility to review and approve Clinical Initiation.  Any disputes at the JSC regarding such approval shall be resolved in accordance with Section 2.5(b)(ii)(C) of the OLCA; provided, however, that, [***].

  4.Upon the JSC’s approval of Clinical Initiation, Gilead will provide Arcus with all data and information that would be required to be included in a Qualifying Data Package for the Gilead CD73 Program to the extent then existing with respect to such Gilead CD73 Program (a “Gilead CD73 Data Package”). Arcus shall have the right to deliver to Gilead an Opt-Out Notice with respect to the Gilead CD73 Program during the period [***] (the “Arcus Review Period”).  If Arcus delivers an Opt-Out Notice for the Gilead CD73 Program, the Parties will discuss, and if necessary, [***].  For the avoidance of doubt, if Arcus does not elect to opt-out of the Gilead CD73 Program by delivering an Opt-Out Notice prior to expiration of the Arcus Review Period, Arcus may not later exercise its opt-out right pursuant to Section 4.7 of the OLCA. 

  5.If Arcus does not deliver to Gilead an Opt-Out Notice prior to expiration of the Arcus Review Period, from and after the expiration of the Arcus Review Period, the Parties will share the Research and Development Costs of the Gilead CD73 Program as an “Optioned Program” in accordance with the terms and conditions of the OLCA; provided, however, that (a) no Option Payment applies to the Gilead CD73 Program and (b) for purposes of Section 9.5 of the OLCA, the Gilead CD73 Program shall be deemed a Royalty [***] Program for purposes of determining the applicable royalty rates.  

   

  6.Unless otherwise set forth in the applicable R&D Plan and Budget for the Gilead CD73 Program, Gilead shall [***], and Arcus shall [***] with respect to the Gilead CD73 Program.  For clarity, [***].

  7.Gilead, on behalf of itself and its Affiliates, hereby grants to Arcus a non-exclusive, royalty-free, sublicensable (solely in accordance with Section 8.7(a)(ii) of the OLCA) license under the Gilead IP, Gilead Collaboration IP and Gilead’s interest in any Joint Collaboration IP, in each case, as necessary to perform (or have performed by permitted subcontractors hereunder) the activities assigned to Arcus under the OLCA or any Ancillary Agreement and Arcus Independent Activities in accordance with the terms of the OLCA or such Ancillary Agreement, in each case, with respect to the Gilead CD73 Program, Arcus CD73 Program and Adenosine Receptor Program.

  a.“Gilead IP’ means Gilead Background Know-How and Gilead Background Patents, in each case, to the extent Controlled by Gilead or its Affiliates.

  b.“Gilead Background Know-How” means, with respect to the Gilead CD73 Program, Information Controlled by Gilead as of the Effective Date or during the Term that is reasonably necessary or useful to Exploit any Optioned Molecule or Optioned Product included in the Gilead CD73 Program, the Arcus CD73 Program or the Adenosine Receptor Program, excluding any Collaboration Know-How.

  c.“Gilead Background Patents” means, with respect to the Gilead CD73 Program, Patents Controlled by Gilead as of the Effective Date or during the Term that (i) claim Gilead Background Know-How for the Gilead CD73 Program, the Arcus CD73 Program or the Adenosine Receptor Program or (ii) are otherwise reasonably necessary or useful to Exploit any Optioned Molecule or Optioned Product included in the Gilead CD73 Program, Arcus 

  2

  

   

  CD73 Program or the Adenosine Receptor Program, excluding, in each case ((i) and (ii)), any Collaboration Patents. 

  8.Furthermore, Gilead agrees that Arcus’s license to the Gilead IP, Gilead Collaboration IP and Gilead’s interest in any Joint Collaboration IP may be [***]. 

  9.Solely for purposes of the licenses and rights granted to Gilead with respect to the Arcus CD73 Program and Adenosine Receptor Program pursuant to Section 8.4 of the OLCA, the Arcus CD73 Program and Adenosine Receptor Program shall each be deemed to include the Gilead CD73 Program, such that Gilead may Exploit any Optioned Molecule or Optioned Product included in the Gilead CD73 Program within the scope of licenses and rights granted to Gilead in Section 8.4 of the OLCA with respect to the Arcus CD73 Program or Adenosine Receptor Program.  Except as set forth in this Section 9 of this Letter Agreement, the Arcus CD73 Program, Adenosine Receptor Program and the Gilead CD73 Program shall be considered separate Optioned Programs.

  10.For avoidance of doubt, (a) Arcus may use any Gilead IP, Gilead Collaboration IP, Joint Collaboration IP and Gilead Confidential Information, in each case, in accordance with the licenses granted under this Letter Agreement with respect to the Gilead CD73 Program, to Exploit the Arcus CD73 Program and Adenosine Receptor Program and (b) Gilead may use any Arcus IP, Arcus Collaboration IP, Joint Collaboration IP and Arcus Confidential Information, in each case, pursuant to the licenses granted to Gilead pursuant to Section 8.4 of the OCLA with respect to the Arcus CD73 Program and Adenosine Receptor Program, to Exploit the Gilead CD73 Program. Upon request by a Party, the other Party will disclose and respond to reasonable requests regarding the use of intellectual property in these programs. 

  11.Solely with respect to the Gilead CD73 Program:

  a.Section 9.5(b)(i) of the OLCA is revised as follows: “(i) [***];” and

  b.the first sentence of Section 9.5(c)(A) of the OLCA is revised as follows: “(A) [***].”

  12.In the event of any termination of the OLCA with respect to the Gilead CD73 Program (or any Optioned Product included therein, as applicable), notwithstanding Section 14.7(c)(i) of the OLCA, Arcus shall have the first right to continue the Gilead CD73 Program.  Arcus will notify Gilead of its decision in writing within [***] days from the date of delivery by Gilead of notice of termination for the Gilead CD73 Program.  If Arcus elects to continue the Gilead CD73 Program, the license granted by Gilead to Arcus under Section 14.7(c)(i) of the OLCA shall be [***].  The Transition Agreement entered into by the Parties with respect to the Gilead CD73 Program shall include [***] to Develop, obtain Regulatory Approval [***].  

  If Arcus does not elect to continue the Gilead CD73 Program, the Gilead CD73 Program shall not revert to Arcus pursuant to Section 14.7(c) of the OLCA and shall remain with Gilead subject to the terms and conditions of this paragraph. If Gilead subsequently (a) [***] or (b) [***] Gilead shall promptly notify Arcus in writing. If Gilead decides [***], the Parties will discuss and negotiate in good faith [***]. If Gilead decides [***] the Parties will discuss and negotiate in good faith [***]. If the Parties are unable to agree [***], then such matter shall be determined pursuant to Section 15.2(a) and Section 15.2(d) of the OLCA.  For the avoidance of doubt, if the terminated Gilead CD73 Program is (i) [***] or (ii) [***], in each case of (i) or (ii), the Gilead CD73 Program shall continue to no longer be an Optioned Program. 

  13.For purposes of the license granted by Gilead to Arcus under Section 14.7(c)(i) of the OLCA with respect to the Gilead CD73 Program:

  3

  

   

  a.“Gilead Reversion Know-How” means any [***].

  b.“Gilead Reversion Patents” means [***].

  For the avoidance of doubt, the licenses granted by Gilead to Arcus under Section 14.7(c)(i) of the OLCA with respect to the Arcus CD73 Program and Adenosine Receptor Program shall be royalty-free, fully paid and perpetual.

  14.The Parties acknowledge and agree that the Gilead CD73 Program is not now and has never been an Arcus Program and in no event shall the Gilead CD73 Program be deemed a current or former Arcus Program. 

  Except as expressly set forth in this Letter Agreement, the terms and conditions of the OLCA shall remain in full force and effect.  This Letter Agreement shall be governed by all of the terms (except as amended by this Letter Agreement) of the OLCA, including, without limitation, Sections 15.1(a) and (b), 15.2(a), (c) and (e), 15.3 – 15.6, 17.2, 17.4, 17.5, 17.8 – 17.13 of the OLCA which are incorporated herein by reference (treating any reference to “Agreement” therein as a reference to “Letter Agreement” instead).  This Letter Agreement, together with the OCLA, sets forth the complete, final and exclusive agreement and all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties with respect to the subject matter hereof and thereof and supersedes all prior agreements and understandings between the Parties existing as of the date hereof with respect to the subject matter hereof and thereof. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the Parties other than as are set forth herein and therein. No subsequent alteration, amendment, change or addition to this Letter Agreement shall be binding upon the Parties unless reduced to writing and signed by an authorized representative of each Party. This Letter Agreement may be executed by facsimile (including a PDF image delivered via e-mail) or electronically transmitted signatures and such signatures shall be deemed to bind each Party hereto as if they were original signatures.

   

  Please confirm your acceptance of and agreement to the foregoing by providing your signature below and returning a fully-executed copy of this Letter Agreement.

   

  [signature page follows]

   

   

   

  4

  

   

  Sincerely,

   

  Gilead Sciences, Inc.

   

   

  By: /s/ Devang Bhuva 	
Name: Devang Bhuva	
Title: SVP, Corporate Development	

  Accepted and agreed:

   

  Arcus Biosciences, Inc.

   

   

  By: /s/ Juan Jaen	
Name: Juan Jaen 	
Title: President 	

   

   

   

   

   

   

   

   

   

   

   

   

   

   

   

  [Signature Page to Letter Agreement re Gilead CD73 Program]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00347-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00347-of-00352.parquet"}]]