Document:

AMENDMENT
No. 5

 

TO
LOAN AGREEMENT

 

This
Amendment to Loan Agreement DRICBDH0615 (the “Amendment”) is made and entered into as of June 26, 2017, by
and between Biodyne Holding SA, a Swiss corporation (the “Lender”) and Hancock Jaffe Laboratories, Inc., a
Delaware corporation, (the “Borrower”).

 

RECITALS

 

WHEREAS,
the Lender and the Borrower are party to a Loan Agreement, dated as of June 30, 2015 (the “Loan Agreement”) and Convertible
Promissory Notes with the right of transfer as determined by the Lender in accordance with Section 4 of the Loan Agreement.

 

WHEREAS,
the Lender and the Borrower desire to amend the Loan Agreement to provide for an extension of funding and repayment periods.

 

NOW,
THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt and sufficiency of
which is hereby acknowledged, the parties hereby agree as follows:

 

Section
1.1 of the Loan Agreement is hereby amended to read as follows:

 

Section
1.1.: This Agreement sets out the terms and conditions upon which the Lender will make available to the Borrower a loan of up
to USD 2,200,000 (two million two hundred thousand US Dollars) in several installments through January 31, 2018.

 

Section
5 of the loan agreement is hereby amended to read as follows:

 

Section
5: REPAYMENT

 

	 	5.1.	The
    Loan shall bear interest at the rate of three per cent (3%) per annum. The interest shall be calculated from the date the
    Lender remits funds to Borrower
	 	5.2.	Interest
    shall be due and payable by the Borrower to the Lender on an annual basis, the first payment to occur on January 31, 2018.
	 	5.3.	The
    Borrower undertakes to repay to the Lender the Loan plus any unpaid interest accruing thereon by January 31, 2018. The Borrower
    is entitled to repay the loan and the accrued interests at any time before January 31, 2018 without penalty.

 

    	 	 	 1

    	 		 

    

 

IN
WITNESS WHEREOF, the parties have executed this Amendment to the Loan Agreement as of the date first written above.

 

	 	“LENDER”
	 	 	 
	 	Biodyne
    Holding SA
	 	 	 
	 	By:	/S/
    YURY ZHIVILO
	 	Yury
    Zhivilo, Managing Director
	 	 	 
	 	“BORROWER”
	 	 	 
	 	HANCOCK
    JAFFE LABORATORIES, INC.
	 	 	 
	 	By:	/S/
    WILLIAM ABBOTT
	 	William
    Abbott, Chief Financial Officer

 

    	 	 	 2Services
and Material Supply Agreement

 

This
Services and Material Supply Agreement (the “Agreement”) is made and entered into effective March 4, 2016 by
and between Hancock Jaffe Laboratories, Inc. (“Client”), a Delaware corporation having a business address at
70 Doppler, Irvine, California, 92618, and ATSCO, Inc. (“Supplier”); a Nevada corporation, having a business
address at 3117 Kingston Drive, Plano, Texas, 75074.

 

RECITALS:

 

WHEREAS,
Client is involved in the manufacture of medical devices for vascular surgery indications employing certain Materials anatomically
defined and derived from abattoir sources; and

 

WHEREAS,
Supplier is experienced in and able to provide abattoir derived Materials, and;

 

WHEREAS,
the Materials referred to in this Agreement are defined in the Client’s purchase orders.

 

NOW,
THEREFORE, in consideration of the foregoing and the mutual covenants hereinafter set forth, the Client and Supplier as may
be referred herein singularly and/or jointly referred to as the Party/Parties hereby agree as follows:

 

1.
Definitions:

 

1.1
The term “Material(s)” shall mean Bovine Veins as specified in Clients Specification for Vein (MD010038).

 

2.
Tenn of Agreement. Subject to the provisions for termination set forth in Section 10 hereof, the term of this Agreement shall
be from March 4, 2016 through 12:00 midnight on March 3, 2019 unless extended or sooner terminated as provided under Sections
7, 8 and 9 herein below. In the event this Agreement is extended as provided in Section 9 hereof, its terms shall continue in
full force and effect, subject to any amendments or modifications mutually agreed upon by the Parties.

 

3.
Services to be Performed. Supplier agrees to provide Client with certain animal derived Materials from abattoir sources and
when applicable comply with the most current revision of the Client’s specifications and procedures. Client shall promptly
notify Supplier in writing regarding any revisions to these specifications and procedures. The term “when applicable”
shall pertain to material supplied for devices fabricated and/or processed for commercial use and/or controlled by certain quality
and regulatory documentation; the term shall not apply to Materials for research and development.

 

    	Services and Material Supply Agreement
	Page 1 of 7

    	 

    

 

3.1
Supplier will train personnel collecting the Materials.

 

3.
2 Supplier will audit the operations of the abattoir.

 

3.4
Supplier will notify Client in the event the abattoir is not in compliance.

 

3.5
Supplier will fill out and maintain associated forms and records as required by Client.

 

4.
Equipment, Supplies and Expenses. Supplier, at Supplier’s expense, will provide all equipment, tools, supplies and other
expenses necessary to perform the services.

 

5.
Time for Performance. Supplier will perform the services at the request of the Client subject to the terms of Section 6 herein
below.

 

6.
Material Orders.

 

6.1
Client agrees to purchase a minimum of 700 (seven hundred) pieces of the material on a monthly calendar basis (“Monthly
Minimum”).

 

6.
2 Delivery details and apportioning of the Monthly Minimum will be mutually agreed upon by Client and Supplier.

 

6.
3 In the event that Client issues a Purchase Order for more than the monthly minimum, Supplier will use all reasonable effort
to meet the Purchase Order request.

 

7.
Price of Materials. Client will pay Supplier as follows;

 

7.1
For the Monthly Minimum, 700 pieces, Client agrees to pay $28,000.00 (twenty-eight thousand dollars).

 

7.2
On a monthly basis Client will pay $21.00 (twenty-one dollars) per piece for each piece of material above the Minimum PO up to
and including 1,000 (one thousand) additional pieces.

 

7.3
On a monthly basis Client will pay $17.00 (seventeen dollars) per piece for each piece of material beyond 1,000 (one thousand).

 

    	Services and Material Supply Agreement
	Page 2 of 7

    	 

    

 

8.
Terms of Payment.

 

8.1
 Supplier will provide Client an invoice for all Materials provided under the Monthly Minimum and any amounts above the Monthly
Minimum.

 

8.2 Payment for the Monthly Minimum will be made to Supplier via a funds transfer to Supplier’s specified banking account
on or before the fifth business day of each month for that month’s Minimum. Payment will be made in good faith and that
when applicable the Materials will be delivered in accordance with and comply with the most current revision of the Client’s
specifications and procedures.

 

8.3 Payment for any amount in accordance with the provisions of Sections 7.2, 7.3 hereinabove will be made via Client’s
business check or other mutually acceptable means within 10 business days of receiving Supplier’s invoice.

 

9.
Extension of Agreement. During the fifth year of this Agreement and no later than 6 (six) months prior to the termination
of the Agreement under the provision of Section 2 herein above, the Parties will in good faith mutually agree to terms for extension
of the Agreement .

 

10.
Termination of Agreement. This Agreement will become effective on the date written herein above and will terminate on the
earlier of the date Supplier completes the services required by this Agreement or the date a Party terminates the Agreement. Either
Party with reasonable cause may terminate this Agreement by giving 90 day written notice of termination for cause. Reasonable
cause includes:

 

10.1
In the event and solely at the fault of the Client the payments are not paid in accordance with the provision of Section 8.2 and
8.3 hereinabove.

 

10.1.1
Section 8 will not apply in the event that payment is not paid or delayed as a fault of banking operations and/or services;
such fault to be remedied in a timely fashion.

 

10.2
When applicable the Supplier solely and or willfully does not comply with the most current revision of the Client’s specifications
and procedures.

 

10.3
The Parties mutually agree to terminate the Agreement without cause or penalty.

 

10.4
The Client fully ceases manufacturing of the products pursuant to the Post Acquisition Supply Agreement with LeMaitre Vascular.
Inc.

 

    	Services and Material Supply Agreement
	Page 3 of 7

    	 

    

 

11.
Termination under Section 10.1 In the event that Supplier exercises the option to terminate the Agreement for non-payment,
Section 10.1, Client will prepay to Supplier any remaining amount equivalent to the sum of the Monthly Minimum equivalent to the
number of months beyond the termination date up to the date of termination in Section 2 herein above. Said prepayment must be
made within 30 (thirty) business days of Supplier providing written notice of termination pursuant to Section 10.

 

12
.. Exclusivity. For the term of this Agreement and for any and all applicable extensions Supplier agrees to provide the Materials
as part of Section 3 herein above only to Client; Supplier shall not provide the Materials to any person(s) or business entity
for similar use whether, but not limited to, for commercial or research and/or development without the express written permission
of the Client.

 

12.1 This section 13 shall apply to anatomically defined Materials presently supplied by Supplier to Client for vascular devices;
Materials other than those presently supplied by Supplier as part of this agreement which may be requested by client under the
provisions of this agreement will not be subject to this Section.

 

12.2
For the purposes of this Agreement the nature of the Materials and other information related to the Materials shall be considered
as confidential property of the Client and subject to the provisions of the Nondisclosure Agreement appended as Attachment A.

 

13.
Independent Supplier Status. The Parties intend Supplier to be an independent Supplier in the performance of the services.
Excepting the provisions of Section 13 herein above and within the stipulations and specifications of the Approved Supplier Specification:

 

13.1
Supplier has the right to perform services for others during the term of this Agreement.

 

13.2
Supplier has the right to hire assistants or to use employees to provide the services required by this.

 

13.3
Client shall not require Supplier or Supplier’s employees to devote full time to performing the services required by this
Agreement.

 

13.4
Neither Supplier nor Supplier’s employees are eligible to participate in any employee pension, health, vacation pay, sick
pay or other fringe benefit plan’ of Client.

 

14.
Disputes. If a dispute including but not limited to the actions provided for under Section 8 herein above arises, the Parties
will try in good faith to settle it through mediation.

 

    	Services and Material Supply Agreement
	Page 4 of 7

    	 

    

 

15.
Indemnification. The Parties indemnify each other for all cause and actions which may be brought or caused to happen either
as part of litigation or other action including but not limited to regulatory actions. Neither Party shall be held accountable
for any expenses of the other Party associated with such actions.

 

16.
No Partnership. This Agreement does not create a partnership relationship. Neither Party has authority to enter into contracts
on the other’s behalf.

 

17.
Entire Agreement. This is the entire Agreement between the Parties. It replaces and supersedes any and all oral agreements
between the Parties, as well as any prior writings.

 

18.
Successors and Assignees. This Agreement binds and benefits successors and assignees of the Parties.

 

19.
Notices. All notices must be in writing. A notice may be delivered to a Party at the addresses herein above or to a
new address that a Party designates in writing. Notices may be delivered in person, by certified mail, or other mutually
acceptable means.

 

20.
Governing Law. This Agreement will be governed by and construed in accordance with the laws of the state of California.

 

21.
Counterparts. This Agreement may be signed by the Parties in different counterparts, including emails and facsimiles, and
the signature pages combined will create a document binding on all Parties.

 

22.
Modification. This Agreement may be modified only by a written agreement signed by the Parties.

 

23.
Waiver. If one Party waives any term or provision of this Agreement at any time, that waiver will be effective only for the
specific instance and specific purpose for which the waiver was given. If either Party fails to exercise or delays exercising
any of its rights or remedies under this Agreement, that Party retains the right to enforce that term or provision at a later
time.

 

24.
Severability. If any court determines that any provision of this Agreement is invalid or unenforceable, any invalidity or
unenforceability will affect only that provision and will not make any other provision of this Agreement invalid or unenforceable
and such provision shall be modified, amended or limited only to the extent necessary to render it valid and enforceable.

 

    	Services and Material Supply Agreement
	Page 5 of 7

    	 

    

 

THIS
SPACE LEFT INTENTIONALLY BLANK

 

SIGNATURE
PAGE FOLLOWS

 

    	Services and Material Supply Agreement
	Page 6 of 7

    	 

    

 

	CLIENT	 
	 	 
	For:
    HANCOCK JAFFE LABORATORIES, INC.	 
	 	 
	/s/ Norman Jaffe	 
	Norman Jaffe, President	 

  

	SUPPLIER	 
	 	 
	For:
    ATSCO, INC.	 
	 	 
	/s/ Richard Forbes	 
	Richard Forbes, President	 

 

    	Services and Material Supply Agreement
	Page 7 of 7

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