Document:

Exhibit 10.1

    

     

    

    
      Execution

    

    
      SPONSOR LETTER AGREEMENT

       

      This SPONSOR LETTER AGREEMENT (this “Agreement”), dated as of February 7, 2021, is made by and among ARYA Sciences Holdings III, an
        exempted company incorporated in the Cayman Islands with limited liability (the “Sponsor”), the other holders of ARYA Class B Shares set forth on Schedule I hereto (the “Other Class B Holders”, and together with the Sponsor, collectively, the “Shareholders”), ARYA Sciences Acquisition Corp III, an exempted company incorporated
        in the Cayman Islands with limited liability (“ARYA”), and Nautilus Biotechnology, Inc., a Delaware corporation (the “Company”).  The Sponsor, the Other
        Class B Holders, ARYA and the Company shall be referred to herein from time to time collectively as the “Parties”.  Capitalized terms used but not otherwise defined herein shall have the meanings
        ascribed to such terms in the Business Combination Agreement (as defined below).

       

      WHEREAS, ARYA, the Company and certain other Persons party thereto entered into that certain Business Combination Agreement, dated as of the date hereof (as it may be amended,
        restated or otherwise modified from time to time in accordance with its terms, the “Business Combination Agreement”); and

       

      WHEREAS, the Business Combination Agreement contemplates that the Parties will enter into this Agreement concurrently with the entry into the Business Combination
          Agreement by the parties thereto, pursuant to which, among other things, (a) the Shareholders agree that they will vote in favor of approval of the Business Combination Agreement and the transactions contemplated thereby (including the
          Domestication and the Merger) and (b) the Shareholders agree to waive any adjustment to the conversion ratio set forth in the Governing Documents of ARYA, including under Article 12 of the Amended and Restated Articles of Association of ARYA, or any other anti-dilution or similar protection with respect to all of the ARYA Class B Shares related to the transactions contemplated by the Business Combination
          Agreement.

       

      NOW, THEREFORE, in consideration of the premises and the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are
        hereby acknowledged, the Parties, each intending to be legally bound, hereby agree as follows:

       

      1.          Agreement to Vote.

       

      a.          Each Shareholder (in his, her or its capacity as a shareholder of ARYA and on behalf of himself, herself and itself and not the other Shareholders) hereby irrevocably agrees, at any
        meeting of the shareholders of ARYA duly called and convened in accordance with the Governing Documents of ARYA, whether or not adjourned and however called, including at the ARYA Shareholders Meeting or otherwise, and in any action by written
        consent of the shareholders of ARYA, (i) to vote, or cause to be voted, or execute and return, or cause to be executed and returned, an action by written consent with respect to, as applicable, all of such Shareholder’s ARYA Class B Shares and ARYA
        Class A Shares (if any) held of record or beneficially by such Shareholder as of the date of this Agreement, or to which such Shareholder acquires record or beneficial ownership after the date hereof and prior to the Closing (collectively, the “Subject ARYA Equity Securities”) in favor of each of the Transaction Proposals, in each case, to the extent Subject ARYA Equity Securities are entitled to vote thereon or consent thereto and (ii) when such
        meeting is held, appear at such meeting or otherwise cause the Subject ARYA Equity Securities to be counted as present thereat for the purpose of establishing a quorum, and (iii) to vote, or cause to be voted against, against or withhold written
        consent, or cause written consent to be withheld, with respect to, as applicable, (A) any ARYA Acquisition Proposal or (B) any other matter, action or proposal that would reasonably be expected to result in (x) a breach of any of the ARYA Parties’
        covenants, agreements or obligations under the Business Combination Agreement  or (y) any of the conditions to the Closing set forth in Sections 6.1 or 6.3 of the Business Combination Agreement not being satisfied.

       

      

      
        
          

      

      
      b.          Without limiting any other rights or remedies of the Company, each Shareholder hereby irrevocably appoints the chief executive officer of the Company or any other officer of the Company
        designated by Company as each Shareholder’s agent, attorney-in-fact and proxy (with full power of substitution and resubstitution), for and in the name, place and stead of each Shareholder, (i) to attend on behalf of each Shareholder any meeting of
        the ARYA Shareholders with respect to the matters described in Section 1(a), (ii) to include the Subject ARYA Equity Securities in any computation for purposes of establishing a quorum at any such meeting of the holders of ARYA Shares and (iii) to
        vote (or cause to be voted), or deliver a written consent (or withhold consent) with respect to, as applicable, the ARYA Equity Securities on the matters specified in, and in accordance and consistent with Section 1(a) in connection with any
        meeting of the holders of ARYA Shares or any action by written consent by the holders of ARYA Shares, in each case, in the event that any Shareholder fails to perform or otherwise comply with the covenants, agreements or obligations set forth in Section

          1(a).

      

      

      c.          The proxy granted by the Shareholder pursuant to Section 1(b) is coupled with an interest sufficient in law to support an irrevocable proxy and is granted in consideration for
        the Company entering into the Business Combination Agreement and agreeing to consummate the transactions contemplated thereby.  The proxy granted by the Shareholder pursuant to Section 1(b) is also a durable proxy and shall survive the
        bankruptcy, dissolution, death, incapacity or other inability to act by the Shareholder and shall revoke any and all prior proxies granted by the Shareholder with respect to the Subject ARYA Equity Securities. The vote or consent of the proxyholder
        in accordance with Section 1(b) and with respect to the matters described in Section 1(a) shall control in the event of any conflict between such vote or consent by the proxyholder of the Subject ARYA Equity Securities and a vote or
        consent by the Shareholder of the Subject ARYA Equity Securities (or any other Person with the power to vote or provide consent with respect to the Subject ARYA Equity Securities) with respect to the matters described in Section 1(a).  The
        proxyholder may not exercise the proxy granted pursuant to Section 1(b) on any matter except for those matters described in Section 1(a).

       

      2.          Waiver of Anti-dilution Protection.  Each Shareholder hereby (a) waives, subject to, and conditioned upon, the occurrence of the Closing (for himself, herself or itself and for
        his, her or its, successors, heirs and assigns), and (b) agrees not to assert or perfect, any rights to adjustment or other anti-dilution protections with respect to the rate that the ARYA Class B Shares held by him, her or it convert into ARYA
        Class A Shares, including those set out in Article 12 of the Amended and Restated Articles of Association of ARYA, in connection with the transactions contemplated by the Business Combination Agreement or
        otherwise.  ARYA hereby acknowledges and agrees to such waiver.  Each Shareholder hereby acknowledges and agrees that upon the Domestication, each ARYA Class B Share will be converted into one (1) share of common stock, par value $0.0001 per share,
        of ARYA (“ARYA Common Stock”) and following the Domestication, no provision of the Pre-Closing ARYA Governing Documents, including Article 12 of the Amended and Restated Articles of Association of ARYA, will be of any force or effect with respect to the shares of ARYA Common Stock.

      
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      3.          Transfer of Shares.

       

      a.          Except as expressly contemplated by the Business Combination Agreement or with the prior written consent of the Company (such consent to be given or withheld in its sole discretion),
        from and after the date hereof, each Shareholder hereby agrees that he, she or it shall not (i) Transfer any of his, her or its Subject ARYA Equity Securities, (ii) enter into (A) any option, warrant, purchase right, or other Contract that could
        (either alone or in connection with one or more events, developments or events (including the satisfaction or waiver of any conditions precedent)) require such Shareholder to Transfer his, her or its Subject ARYA Equity Securities or (B) any voting
        trust, proxy or other Contract with respect to the voting or Transfer of the Subject ARYA Equity Securities in a manner inconsistent with the covenants and obligations of this Agreement, or (iii) enter into any Contract to take, or cause to be
        taken, any of the actions set forth in  clauses (i) or (ii); provided, however, that the foregoing shall not apply to any Transfer (1) to ARYA’s officers or directors, any members or partners of the Sponsor, any
        affiliates of the Sponsor, or any employees of such affiliate; (2) in the case of an individual, by gift to a member of one of the individual’s immediate family, to a trust, the beneficiary of which is a member of the individual’s immediate family
        or an Affiliate of such individual; (3) in the case of an individual, by virtue of laws of descent and distribution upon death of the individual; (4) in the case of an individual, pursuant to a qualified domestic relations order; or (5) by virtue
        of the Sponsor’s organizational documents upon liquidation or dissolution of the Sponsor; provided, that the transferring Shareholder shall, and shall cause any transferee of his, her or its Subject ARYA Securities of the type set forth in
        clauses (1) through (5), to enter into a written agreement in form and substance reasonably satisfactory to the Company, agreeing to be bound by this Agreement (which will include, for the avoidance of doubt, all of the covenants, agreements and
        obligations of the transferring Shareholder hereunder and the making of all applicable representations and warranties of the transferring Shareholder set forth in Section 6 with respect to such transferee and his, her or its Subject ARYA
        Equity Securities received upon such Transfer, as applicable) prior and as a condition to the occurrence of such Transfer.  For purposes of this Agreement, “Transfer” means any, direct or indirect,
        sale, transfer, assignment, pledge, mortgage, exchange, hypothecation, grant of a security interest or encumbrance in or disposition of an interest (whether with or without consideration, whether voluntarily or involuntarily or by operation of law
        or otherwise).

       

      b.          In furtherance of the foregoing, ARYA hereby agrees to (i) place a revocable stop order on all Subject ARYA Equity Securities subject to Section 3(a), including those which may
        be covered by a registration statement, and (ii) notify ARYA’s transfer agent in writing of such stop order and the restrictions on such Subject ARYA Equity Securities under Section 3(a) and direct ARYA’s transfer agent not to process any
        attempts by any such Shareholder to Transfer any Subject ARYA Equity Securities except in compliance with Section 3(a); for the avoidance of doubt, the obligations of ARYA under this Section 3(b) shall be deemed to be satisfied by
        the existence of any similar stop order or restrictions currently existing on the Subject ARYA Equity Securities.

       

      4.          Other Covenants.

       

      a.          Each Shareholder hereby agrees that he, she or it shall (i) be bound by and subject to Sections 5.3(a) (Confidentiality and Access to Information) and 5.4(a) (Public Announcements) of
        the Business Combination Agreement to the same extent as such provisions apply to the parties to the Business Combination Agreement, as if such Shareholder is directly a party thereto, and (ii) not, directly or indirectly, take any action that ARYA
        is prohibited from taking pursuant to Section 5.7(a) (Exclusive Dealing) of the Business Combination Agreement.

      
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      b.          Each Shareholder acknowledges and agrees that the Company is entering into the Business Combination Agreement in reliance upon each Shareholder entering into this Agreement and agreeing
        to be bound by, and perform, or otherwise comply with, as applicable, the agreements, covenants and obligations contained in this Agreement and but for each such Shareholder entering into this Agreement and agreeing to be bound by, and perform, or
        otherwise comply with, as applicable, the agreements, covenants and obligations contained in this Agreement, the Company would not have entered into or agreed to consummate the transactions contemplated by the Business Combination Agreement or the
        Ancillary Documents.

       

      c.          Each Shareholder hereby agrees that it shall not exercise or submit a request to exercise the ARYA Shareholder Redemption with respect to any ARYA Class A Shares held by him, her or it.

       

      5.          Termination of Lock-up Period.  Each of the Shareholders hereby agrees that subject to, and conditioned upon the occurrence and effective as of, the Closing, Section 5 of that
        certain Letter Agreement, dated August 6, 2020 (the “Insider Letter Agreement”), by and among ARYA, the Shareholders and the other members of the ARYA Board, shall be amended and restated in its
        entirety as follows:

       

      

      “5.    Reserved.” 

       

      

      The amendment and restatement of the Insider Letter Agreement set forth in this Section 5 shall be void and of no force and effect if the Business Combination Agreement is terminated in accordance with its
        terms.

       

      6.          Representations and Warranties.  Each Shareholder represents and warrants, solely with respect to himself, herself or itself and not any of the other Shareholders, to the Company
        as follows:

       

      a.          If such Shareholder is an entity, such Shareholder is a corporation, limited liability company or other applicable business entity duly organized or formed, as applicable, validly
        existing and in good standing (or the equivalent thereof, if applicable, in each case, with respect to the jurisdictions that recognize the concept of good standing or any equivalent thereof) under the Laws of its jurisdiction of formation or
        organization (as applicable).

       

      b.          If such Shareholder is an entity, such Shareholder has the requisite corporate, limited liability company or other similar power and authority or, if such Shareholder is an individual,
        has the legal capacity and the requisite power and authority to execute and deliver this Agreement, to perform his, her or its covenants, agreements and obligations hereunder (including, for the avoidance of doubt, those covenants, agreements and
        obligations hereunder that relate to the provisions of the Business Combination Agreement), and to consummate the transactions contemplated hereby.  If such Shareholder is an entity, the execution and delivery of this Agreement has been duly
        authorized by all necessary corporate (or other similar) action on the part of such Shareholder.  This Agreement has been duly and validly executed and delivered by such Shareholder and constitutes a valid, legal and binding agreement of such
        Shareholder (assuming that this Agreement is duly authorized, executed and delivered by the other Parties hereto), enforceable against such Shareholder in accordance with its terms (subject to applicable bankruptcy, insolvency, reorganization,
        moratorium or other Laws affecting generally the enforcement of creditors’ rights and subject to general principles of equity).

       

      

      c.          No consent, approval or authorization of, or designation, declaration or filing with, any Governmental Entity is required on the part of such Shareholder with respect to such
        Shareholder’s execution, delivery or performance of his, her or its covenants, agreements or obligations under this Agreement (including, for the avoidance of doubt, those covenants, agreements and obligations under this Agreement that relate to
        the provisions of the Business Combination Agreement) or the consummation of the transactions contemplated hereby, except for any consents, approvals, authorizations, designations, declarations, waivers or filings, the absence of which would not
        adversely affect the ability of such Shareholder to perform, or otherwise comply with, any of his, her or its covenants, agreements or obligations hereunder in any material respect.

       

      d.          None of the execution or delivery of this Agreement by such Shareholder, the performance by such Shareholder of any of his, her or its covenants, agreements or obligations under this
        Agreement (including, for the avoidance of doubt, those covenants, agreements and obligations under this Agreement that relate to the provisions of the Business Combination Agreement) or the consummation of the transactions contemplated hereby
        will, directly or indirectly (with or without due notice or lapse of time or both) (i) if such Shareholder is an entity, result in any breach of any provision of such Shareholder’s Governing Documents, (ii) result in a violation or breach of, or
        constitute a default or give rise to any right of termination, Consent, cancellation, amendment, modification, suspension, revocation or acceleration under, any of the terms, conditions or provisions of any Contract to which such Shareholder is a
        party, (iii) violate, or constitute a breach under, any Order or applicable Law to which such Shareholder or any of his, her or its properties or assets are bound or (iv) result in the creation of any Lien upon the Subject ARYA Equity Securities,
        except, in the case of any of clauses (ii) through (iv) above, as would not adversely affect the ability of such Shareholder to perform, or otherwise comply with, any of his, her or its covenants, agreements or obligations hereunder in any material
        respect.

       

      

      
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       e.          Such Shareholder is the record and/or beneficial owner, as applicable, of the Subject ARYA Equity Securities and has valid, good and marketable title to the Subject ARYA Equity
        Securities, free and clear of all Liens (other than transfer restrictions under applicable Securities Law, under the ARYA Governing Documents, under the Insider Letter Agreement or under the other Contracts set forth on Section 4.6(c) of the ARYA
        Disclosure Schedules).  Except for the Equity Securities of ARYA set forth on Schedule II hereto, together with any other Equity Securities of ARYA that such Shareholder acquires record or beneficial ownership after the date hereof that is
        either permitted pursuant to or acquired in accordance with Section 5.11(h) of the Business Combination Agreement, such Shareholder does not own, beneficially or of record, any Equity Securities of ARYA or have the right to acquire any Equity
        Securities of ARYA.  Such Shareholder has the sole right to vote (and provide consent in respect of, as applicable) the Subject ARYA Equity Securities and, except for this Agreement, the Business Combination Agreement, the Governing Documents of
        ARYA, the Contracts set forth on Section 4.6(c) of the ARYA Disclosure Schedules, or any proxy given for purposes of voting in favor of the Transaction Proposals, such Shareholder is not party to or bound by (i) any option, warrant, purchase right,
        or other Contract that would (either alone or in connection with one or more events, developments or events (including the satisfaction or waiver of any conditions precedent)) require such Shareholder to Transfer any of the Subject ARYA Equity
        Securities or (ii) any voting trust, proxy or other Contract with respect to the voting or Transfer of any of the Subject ARYA Equity Securities in a manner inconsistent with the requirements of this Agreement. The Shareholders, collectively, hold
        100% of the issued and outstanding ARYA Class B Shares as of the date hereof.

       

      

      f.          There is no Proceeding pending or, to such Shareholder’s knowledge, threatened in writing against or involving such Shareholder or any of his, her or its Affiliates that, if adversely
        decided or resolved, would reasonably be expected to adversely affect the ability of such Shareholder to perform, or otherwise comply with, any of its covenants, agreements or obligations under this Agreement in any material respect.

       

      g.          Such Shareholder, on his, her or its own behalf and on behalf of his, her or its Representatives, acknowledges, represents, warrants and agrees that (i) he, she or it has conducted his,
        her or its own independent review and analysis of, and, based thereon, has formed an independent judgment concerning, the business, assets, condition, operations and prospects of, the Company and the transactions contemplated by this Agreement, the
        Business Combination Agreement and the other Ancillary Documents to which he, she or it is or will be a party and (ii) he, she or it has been furnished with or given access to such documents and information about the Company and their respective
        businesses and operations as he, she or it and his, her or its Representatives have deemed necessary to enable him, her or it to make an informed decision with respect to the execution, delivery and performance of this Agreement or the other
        Ancillary Documents to which he, she or it is or will be a party and the transactions contemplated hereby and thereby.

       

      h.          In entering into this Agreement and the other Ancillary Documents to which he, she or it is or will be a party, such Shareholder has relied solely on his, her or its own investigation
        and analysis and the representations and warranties expressly set forth in the Ancillary Documents to which he, she or it is or will be a party and no other representations or warranties of the Company (including, for the avoidance of doubt, none
        of the representations or warranties of the Company set forth in the Business Combination Agreement or any other Ancillary Document to which such Shareholder is not and will not be a party) or any other Person, either express or implied, and such
        Shareholder, on his, her or its own behalf and on behalf of his, her or its Representatives, acknowledges, represents, warrants and agrees that, except for the representations and warranties expressly set forth in this Agreement or in the other
        Ancillary Documents to which he, she or it is or will be a party, none of the Company or any other Person makes or has made any representation or warranty, either express or implied, in connection with or related to this Agreement, the Business
        Combination Agreement or the other Ancillary Documents or the transactions contemplated hereby or thereby.

       

      i.          Such Shareholder hereby acknowledges and agrees that he, she, or it shall not receive (whether in his, her or its capacity as a shareholder of ARYA or otherwise) from ARYA any finder’s
        fee, reimbursement, consulting fee, monies in respect of any repayment of a loan or other compensation prior to, or in connection with any services rendered in order to effectuate the consummation of the transactions contemplated by the Business
        Combination Agreement, except as otherwise expressly contemplated by the Business Combination Agreement, and excluding, for the avoidance of doubt, his, her or its ARYA Shares.

      
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      7.          Termination.  This Agreement shall automatically terminate, without any notice or other action by any Party, and be void ab initio upon
        the earlier of (a) the Effective Time and (b) the termination of the Business Combination Agreement in accordance with its terms.  Upon termination of this Agreement as provided in the immediately preceding sentence, none of the Parties shall have
        any further obligations or Liabilities under, or with respect to, this Agreement.  Notwithstanding the foregoing or anything to the contrary in this Agreement, (i) the termination of this Agreement pursuant to Section 7(b) shall not
        affect any Liability on the part of any Party for a Willful Breach of any covenant or agreement set forth in this Agreement prior to such termination, (ii)  Section 4(a)(i) (solely to the extent that it relates to Section 5.3(a)
        (Confidentiality and Access to Information) of the Business Combination Agreement) and the representations and warranties set forth in Sections 6(g) and (h) shall each survive the termination of this Agreement, (iii) Section
          4(a)(i) (solely to the extent that it relates to Section 5.4(a) (Public Announcements) of the Business Combination Agreement) and Section 18 shall each survive the termination of this Agreement pursuant to Section 7(a),
        and (iv) this Section 7, Section 8, Section 9, Section 14, Section 16, Section 17 and Sections 10 through 13, 15 and 19 through 24 (to the extent related to
        any of the provisions that survive the termination of this Agreement) shall survive any termination of this Agreement. For purposes of this Section 7, (x) “Willful Breach” means a
        material breach that is a consequence of an act undertaken or a failure to act by the breaching Party with the knowledge that the taking of such act or such failure to act would, or would reasonably be expected to, constitute or result in a breach
        of this Agreement and  (y) “Fraud” means an act or omission by a Party, and requires: (A) a false or incorrect representation or warranty expressly set forth in this Agreement, (B) with actual
        knowledge (as opposed to constructive, imputed or implied knowledge) by the Party making such representation or warranty that such representation or warranty expressly set forth in this Agreement is false or incorrect, (C) an intention to deceive
        another Party, to induce him, her or it to enter into this Agreement, (D) another Party, in justifiable or reasonable reliance upon such false or incorrect representation or warranty expressly set forth in this Agreement, causing such Party to
        enter into this Agreement, and (E) another Party to suffer damage by reason of such reliance. For the avoidance of doubt, “Fraud” does not include any claim for equitable fraud, promissory fraud, unfair dealings fraud or any torts (including a
        claim for fraud or alleged fraud) based on negligence or recklessness.

       

      8.          No Recourse.  Except for claims pursuant to the Business Combination Agreement or any other Ancillary Document by any party(ies) thereto against any other party(ies) thereto on
        the terms and subject to the conditions therein, each Party agrees that (a) this Agreement may only be enforced against, and any action for breach of this Agreement may only be made against, the Parties, and no claims of any nature whatsoever
        (whether in tort, contract or otherwise) arising under or relating to this Agreement, the negotiation hereof or its subject matter, or the transactions contemplated hereby shall be asserted against any Company Affiliated Party or any ARYA
        Affiliated Party (other than the Shareholders named as parties hereto), and (b) no Company Affiliated Party or ARYA Affiliated Party (other than the Shareholders named as parties hereto), shall have any Liability arising out of or relating to this
        Agreement, the negotiation hereof or its subject matter, or the transactions contemplated hereby, including with respect to any claim (whether in tort, contract or otherwise) for breach of this Agreement or in respect of any written or oral
        representations made or alleged to be made in connection herewith, or for any actual or alleged inaccuracies, misstatements or omissions with respect to any information or materials of any kind furnished in connection with this Agreement, the
        negotiation hereof or the transactions contemplated hereby.  Notwithstanding anything to the contrary in this Agreement, (i) in no event shall any Shareholder have any obligations or Liabilities related to or arising out of the covenants,
        agreements, obligations, representations or warranties of any other Shareholder under this Agreement (including related to or arising out of the breach of any such covenant, agreement, obligation, representation or warranty by any other
        Shareholder), (ii) in no event shall ARYA have any obligations or Liabilities related to or arising out of the covenants, agreements, obligations, representations or warrants of any Shareholder under this Agreement (including related to or arising
        out of any breach of any such covenant, agreement, obligation, representation or warranty by any such Shareholder).

      
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      9.          Fiduciary Duties.  Notwithstanding anything in this Agreement to the contrary, (a) each Shareholder makes no agreement or understanding herein in any capacity other than in such
        Shareholder’s capacity as a record holder and/or beneficial owner of the Subject ARYA Equity Securities, and not, in the case of each Other Class B Shareholder in such Other Class B Shareholder’s capacity as a director, officer or employee of any
        ARYA Party, and (b) nothing herein will be construed to limit or affect any action or inaction by each Other Class B Shareholder or any representative of the Sponsor serving as a member of the board of directors (or other similar governing body) of
        any ARYA Party or as an officer, employee or fiduciary of any ARYA Party, in each case, acting in such person’s capacity as a director, officer, employee or fiduciary of such ARYA Party.

       

      10.          No Third Party Beneficiaries.  This Agreement shall be for the sole benefit of the Parties and their respective successors and permitted assigns and is not intended, nor shall
        be construed, to give any Person, other than the Parties and their respective successors and assigns, any legal or equitable right, benefit or remedy of any nature whatsoever by reason this Agreement.  Nothing in this Agreement, expressed or
        implied, is intended to or shall constitute the Parties, partners or participants in a joint venture.

       

      11.          Notices .  All notices, requests, claims, demands and other communications hereunder shall be in writing and shall be given (and shall be deemed to have been duly given)
        by delivery in person, by e-mail (having obtained electronic delivery confirmation thereof (i.e., an electronic record of the sender that the email was sent to the intended recipient thereof without an “error” or similar message that such email was
        not received by such intended recipient)), or by registered or certified mail (postage prepaid, return receipt requested) (upon receipt thereof) to the other Parties as follows:

       

      If to any Shareholder, to:

       

      
        	c/o ARYA Science Acquisition Corp.
	51 Astor Place, 10th Floor
	New York, NY 10003
	Attention: 

              	Michael Altman
	 	Konstantin Poukalov
	Email:	altman@perceptivelife.com
	 	konstantin@perceptivelife.com

      

      

      

      with a copy (which shall not constitute notice) to:

      

      

      
        
          	Kirkland & Ellis LLP

                
	601 Lexington Avenue
	New York, NY 10022
	Attention: 

                	Jonathan Davis, P.C.
	 	Ryan Brissette
	Email:	jonathan.davis@kirkland.com
	 	ryan.brissette@kirkland.com

        

      

      

        

        

      

      

                  

      

      

           

      

      

      

       

      

      
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      If to the Company, to:

       

      

      
        
          
            	Nautilus Biotechnology, Inc.
	PO Box 22027
	Seattle, WA 98122
	Attention: 

                  	Sujal Patel, Chief Executive Officer
	Email:	smpatel@nautilus.bio

          

        

      

      

      

      

      

      

      

              

      

      

                  

       

      with a copy (which shall not constitute notice) to

       

      
        
          
            	Wilson Sonsini Goodrich & Rosati, P.C.
	650 Page Mill Road
	Palo Alto, CA 94304
	Attention: 

                  	Robert Kornegay
	Email:	rkornegay@wsgr.com

          

        

      

      

      

      

      

      

      

       

      

      

      

      

      

      with a copy (which shall not constitute notice) to:

       

      
        
          
            	Wilson Sonsini Goodrich & Rosati, P.C.
	One Market Plaza, Spear Tower, Suite 3300
	San Francisco, CA 94105
	Attention: 

                  	Robert T. Ishii
	 	Brian Keyes
	Email:	rishii@wsgr.com
	 	bkeyes@wsgr.com

          

        

      

      

      

      

      

      

      

      

        

      

          

      

      

      

       

      

       

      

      or to such other address as the Party to whom notice is given may have previously furnished to the others in writing in the manner set forth above.

       

      12.          Entire Agreement.  This Agreement, the Business Combination Agreement and documents referred to herein or therein, constitutes the entire agreement of the Parties with respect
        to the subject matter of this Agreement, and supersedes all prior agreements and undertakings, both written and oral, among the Parties with respect to the subject matter of this Agreement, except as otherwise expressly provided in this Agreement.

       

      13.          Amendments and Waivers; Assignment  Any provision of this Agreement may be amended or waived if, and only if, such amendment or waiver is in writing and signed by each Party
        hereto. Notwithstanding the foregoing, no failure or delay by any Party in exercising any right hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise of any other right
        hereunder.  Neither this Agreement nor any of the rights, interests or obligations hereunder shall be assignable by any Party without the other Party’s prior written consent (to be withheld or given in its sole discretion).  Any attempted
        assignment of this Agreement not in accordance with the terms of this Section 13 shall be void. 

       

      14.          Fees and Expenses.  All fees and expenses incurred in connection with this Agreement and the transactions contemplated hereby, including the fees and disbursements of counsel,
        financial advisors and accountants, shall be paid by the Party incurring such fees or expenses; provided, that, any such fees and expenses incurred by the Shareholders shall be deemed to be ARYA Expenses. 

       

      

      
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      15.          Remedies.  Except as otherwise expressly provided herein, any and all remedies provided herein will be deemed cumulative with and not exclusive of any other remedy conferred
        hereby, or by law or equity upon such Party, and the exercise by a Party of any one remedy shall not preclude the exercise of any other remedy.  The Parties agree that irreparable damage for which monetary damages, even if available, would not be
        an adequate remedy, would occur in the event that either Party does not perform his, her or its respective obligations under the provisions of this Agreement in accordance with their specific terms or otherwise breach such provisions.  It is
        accordingly agreed that each Party shall be entitled to an injunction or injunctions, specific performance and other equitable relief to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement, in
        each case, without posting a bond or undertaking and without proof of damages and this being in addition to any other remedy to which they are entitled at law or in equity.  Each Party agrees that it shall not oppose the granting of an injunction,
        specific performance and other equitable relief when expressly available pursuant to the terms of this Agreement on the basis that the other parties have an adequate remedy at law or an award of specific performance is not an appropriate remedy for
        any reason at law or equity.

       

      16.          No Ownership Interest.   Nothing contained in this Agreement will be deemed to vest in the Company any direct or indirect ownership or incidents of ownership of or with respect
        to the Subject ARYA Equity Securities.  All rights, ownership and economic benefits of and relating to the Subject ARYA Equity Securities shall remain vested in and belong to the applicable Shareholder, and the Company shall have no authority to
        manage, direct, superintend, restrict, regulate, govern or administer any of the policies or operations of ARYA or exercise any power or authority to direct such Shareholder in the voting of any of the Subject ARYA Equity Securities, except as
        otherwise expressly provided herein with respect to the Subject ARYA Equity Securities.  Except as otherwise expressly provided in Section 1, such Shareholder shall not be restricted from voting in favor of, against or abstaining with
        respect to or giving (or withholding) its written consent to any other matters presented to the shareholders of ARYA.

       

      17.          Acknowledgements. Each Party acknowledges that (a) Kirkland & Ellis LLP, counsel for ARYA and ARYA Sponsor, is representing ARYA and ARYA Sponsor in connection with this
        Agreement, the Business Combination Agreement, the Ancillary Documents and the transactions contemplated hereby and thereby, (b) Wilson Sonsini Goodrich & Rosati, Professional Corporation, counsel for the Company, is representing the Company in
        connection with this Agreement, the Business Combination Agreement, the Ancillary Documents and the transactions contemplated hereby and thereby, (c) none of the foregoing firms is representing the Other Class B Shareholders in connection with this
        Agreement, the Merger, the Business Combination Agreement, the Ancillary Documents or the transactions contemplated hereby, thereby or otherwise and (d) each Other Class B Shareholder acknowledges that he, she or it has had the opportunity to
        consult with its, his or her own counsel.

       

      18.          Non-Survival. The representations and warranties, and each of the agreements and covenants (to the extent such agreement or covenant contemplates or requires performance at or
        prior to the Effective Time) in this Agreement shall terminate at the Effective Time. Each covenant and agreement contained herein that, by its terms, expressly contemplates performance after the Effective Time shall so survive the Effective Time
        in accordance with its terms.

      

      

      19.          Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware, without giving effect to any choice of law or conflict of
        law provision or rule (whether of the State of Delaware or any other jurisdiction) that would cause the application of the law of any jurisdiction other than the State of Delaware.

       

      

      
        9

        
          

      

      20.          Construction; Interpretation. The headings set forth in this Agreement are inserted for convenience only and shall not affect in any way the meaning or interpretation of this
        Agreement.  No Party, nor its respective counsel, shall be deemed the drafter of this Agreement for purposes of construing the provisions hereof, and all provisions of this Agreement shall be construed according to their fair meaning and not
        strictly for or against any Party.  Unless otherwise indicated to the contrary herein by the context or use thereof: (a) the words, “herein,” “hereto,” “hereof” and words of similar import refer to this Agreement as a whole, including the Schedules
        and Exhibits, and not to any particular section, subsection, paragraph, subparagraph or clause set forth in this Agreement; (b) masculine gender shall also include the feminine and neutral genders, and vice versa; (c) words importing the singular
        shall also include the plural, and vice versa; (d) the words “include,” “includes” or “including” shall be deemed to be followed by the words “without limitation”; (e) references to “$” or “dollar” or “US$” shall be references to United States
        dollars; (f) the word “or” is disjunctive but not necessarily exclusive; (g) the words “writing”, “written” and comparable terms refer to printing, typing and other means of reproducing words (including electronic media) in a visible form; (h) the
        word “day” means calendar day unless Business Day is expressly specified; (i) the word “extent” in the phrase “to the extent” means the degree to which a subject or other thing extends, and such phrase shall not mean simply “if”; (j) all references
        to Articles, Sections, Exhibits or Schedules are to Articles, Sections, Exhibits and Schedules of this Agreement; (k) all references to any Law will be to such Law as amended, supplemented or otherwise modified or re-enacted from time to time; and
        (l) all references to any Contract are to that Contract as amended or modified from time to time in accordance with the terms thereof (subject to any restrictions on amendments or modifications set forth in this Agreement).  If any action under
        this Agreement is required to be done or taken on a day that is not a Business Day, then such action shall be required to be done or taken not on such day but on the first succeeding Business Day thereafter.

      

      

      21.          Severability.  Whenever possible, each provision of this Agreement will be interpreted in such a manner as to be effective and valid under applicable Law, but if any term or
        other provision of this Agreement is held to be invalid, illegal or unenforceable under applicable Law, all other provisions of this Agreement shall remain in full force and effect so long as the economic or legal substance of the transactions
        contemplated hereby is not affected in any manner materially adverse to any Party.  Upon such determination that any term or other provision of this Agreement is invalid, illegal or unenforceable under applicable Law, the Parties shall negotiate in
        good faith to modify this Agreement so as to effect the original intent of the Parties as closely as possible in an acceptable manner in order that the transactions contemplated hereby are consummated as originally contemplated to the greatest
        extent possible.

      

      

      22.          Counterparts; Electronic Signatures.  This Agreement may be executed in one or more counterparts, each of which shall be deemed to be an original, but all of which shall
        constitute one and the same agreement.  Delivery of an executed counterpart of a signature page to this Agreement by e-mail, or scanned pages shall be effective as delivery of a manually executed counterpart to this Agreement.

       

      

      

      
        10

        
          

      

      23.          Waiver of Jury Trial.  THE PARTIES EACH HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY RIGHT TO TRIAL BY JURY OF ANY PROCEEDING, CLAIM, DEMAND, ACTION, OR CAUSE OF
        ACTION (I) ARISING UNDER THIS AGREEMENT OR (II) IN ANY WAY CONNECTED WITH OR RELATED OR INCIDENTAL TO THE DEALINGS OF THE PARTIES IN RESPECT OF THIS AGREEMENT OR ANY OF THE TRANSACTIONS RELATED HERETO OR THERETO OR ANY FINANCING IN CONNECTION WITH
        THE TRANSACTIONS CONTEMPLATED HEREBY OR ANY OF THE TRANSACTIONS CONTEMPLATED THEREBY, IN EACH CASE, WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER IN CONTRACT, TORT, EQUITY, OR OTHERWISE.  THE PARTIES EACH HEREBY AGREES AND CONSENTS THAT
        ANY SUCH PROCEEDING, CLAIM, DEMAND, ACTION OR CAUSE OF ACTION SHALL BE DECIDED BY COURT TRIAL WITHOUT A JURY AND THAT THE PARTIES MAY FILE AN ORIGINAL COUNTERPART OF A COPY OF THIS AGREEMENT WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT OF THE
        PARTIES HERETO TO THE WAIVER OF THEIR RIGHT TO TRIAL BY JURY.  EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (A) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE
        EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (B) EACH SUCH PARTY UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF THIS WAIVER, (C) EACH SUCH PARTY MAKES THIS WAIVER VOLUNTARILY AND (D) EACH SUCH PARTY HAS BEEN INDUCED TO ENTER INTO
        THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 23.

      

      

      24.          Submission to Jurisdiction.  Each of the Parties irrevocably and unconditionally submits to the exclusive jurisdiction of the Chancery Court of the State of Delaware (or, if the
        Chancery Court of the State of Delaware declines to accept jurisdiction, the Superior Court of the State of Delaware, or the United States District Court for the District of Delaware), for the purposes of any Proceeding, claim, demand, action or
        cause of action (a) arising under this Agreement or (b) in any way connected with or related or incidental to the dealings of the Parties in respect of this Agreement or any of the transactions contemplated hereby or any of the transactions
        contemplated thereby, and irrevocably and unconditionally waives any objection to the laying of venue of any such Proceeding in any such court, and further irrevocably and unconditionally waives and agrees not to plead or claim in any such court
        that any such Proceeding has been brought in an inconvenient forum.  Each Party hereby irrevocably and unconditionally waives, and agrees not to assert, by way of motion or as a defense, counterclaim or otherwise, in any Proceeding claim, demand,
        action or cause of action against such Party (i) arising under this Agreement or (ii) in any way connected with or related or incidental to the dealings of the Parties in respect of this Agreement or any of the transactions contemplated hereby or
        any of the transactions contemplated thereby, (A) any claim that such Party is not personally subject to the jurisdiction of the courts as described in this Section 24 for any reason, (B) that such Party or such Party’s property is exempt
        or immune from the jurisdiction of any such court or from any legal process commenced in such courts (whether through service of notice, attachment prior to judgment, attachment in aid of execution of judgment, execution of judgment or otherwise)
        and (C) that (x) the Proceeding, claim, demand, action or cause of action in any such court is brought against such Party in an inconvenient forum, (y) the venue of such Proceeding, claim, demand, action or cause of action against such Party is
        improper or (z) this Agreement, or the subject matter hereof, may not be enforced against such Party in or by such courts.  Each Party agrees that service of any process, summons, notice or document by registered mail to such party’s respective
        address set forth in Section 11 shall be effective service of process for any such Proceeding, claim, demand, action or cause of action.

       

      [signature page follows]

       

      

      
        11

        
          

      

      IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be duly executed on its behalf as of the day and year first above written.

       

      ARYA SCIENCES HOLDINGS III

       

      
        
          	

                	By:          	/s/ Michael Altman	

                

        

      

      	

            	Name:	
              Michael Altman

            

      	

            	Title:	
              Authorized Signatory

            

       

       NAUTILUS BIOTECHNOLOGY, INC.

       

      
        
          	

                	By:          	/s/ Sujal Patel	

                

        

      

      	

            	Name:	
              Sujal Patel

            

      	

            	Title:	
              Chief Executive Officer

            

      

      

       

      ARYA SCIENCES ACQUISITION CORP III

       

      
        
          	

                	By:          	/s/ Michael Altman	

                

        

      

      	

            	Name:	
              Michael Altman

            

      
        	

              	Title:	Chief Financial Officer

      

      
         

        

        [Signature Page to Sponsor Letter Agreement]

         

        

      

      
        
          

      

      OTHER CLASS B SHAREHOLDERS

       

      
        
          
            	

                  	

                  	/s/ Saqib Islam	

                  

          

        

      

      
        
          
            	

                  	

                  	Saqib Islam	

                  

          

        

      

      

      

      
        
          
             

            

            	

                  	

                  	/s/ Todd Wider	

                  

          

        

      

      

      
        
          
            	

                  	        

                  	Todd Wider	

                  

          

        

      

      

      

      
        
          
            	

                  	          

                  	/s/ Bradley Campbell	

                  

          

        

      

      

      
        
          
            	

                  	        

                  	Bradley Campbell	

                  

          

        

      

      

       

      [Signature Page to Sponsor Letter Agreement] 

      

      

      
        
          

      

      SCHEDULE I

       

      Other Class B Holders

       

      	1.	
              Bradley Campbell

            

       

      	2.	
              Saqib Islam

            

       

      	3.	
              Todd Wider

            

       

      

      
        
          

      

      SCHEDULE II

       

      ARYA Equity Securities as of February 7, 2021

       

      

      

      	
              Shareholder

            	
              Number of ARYA Class A Shares

            	
              Number of ARYA Class B Shares

            
	
              Sponsor

            	
              499,000

            	
              3,647,500

            
	
              Bradley Campbell

            	
              0

            	
              30,000

            
	
              Saqib Islam

            	
              0

            	
              30,000

            
	
              Todd Wider

            	
              0

            	
              30,000Exhibit 10.2

    

    

    EXECUTION VERSION

    

    

     

    Amended and Restated Registration Rights and Lock-Up Agreement

     

    This Amended and Restated Registration Rights and Lock-Up Agreement (this “Agreement”), dated as of February 7, 2021, is among ARYA Sciences Acquisition Corp
      III, a Cayman Islands exempted company (the “Company”) and the other parties hereto identified as a “Holder” on the signature pages and Schedule A hereto (each, a “Holder”
      and collectively, the “Holders”). Capitalized terms used but not defined herein have the meanings assigned to them in the Business Combination Agreement dated as of the date hereof (the “Business Combination Agreement”), among the Company, Mako Merger Sub, Inc., a Delaware corporation (“Merger Sub”), and Nautilus Biotechnology, Inc., a Delaware corporation (“Nautilus”).

     

    WHEREAS, the Company, Merger Sub and Nautilus are parties to the Business Combination Agreement, pursuant to which, among other things, on the Closing Date, Merger Sub will merge (the “Merger”) with and into Nautilus, with Nautilus surviving the Merger as a wholly-owned subsidiary of the Company, and the Company will redomesticate as a Delaware corporation and change its name to “Nautilus
      Biotechnology, Inc.”;

     

    WHEREAS, the Company, ARYA Sciences Holdings III, a Cayman Islands exempted limited company (the “Sponsor”) and the Independent Directors (as defined herein,
      and, together with the Sponsor, the “Original Holders”) are parties to the Registration and Shareholder Rights Agreement dated as of August 11, 2020 (the “Prior Agreement”);

     

    WHEREAS, the (i) Holders designated as “New Holders” on Schedule A (the “New Holders”) and (ii) Perceptive Life
      Sciences Master Fund Ltd., a Cayman Islands exempted company (“Perceptive”), will receive upon consummation of the Merger shares of the Company’s Common Stock on the Closing Date pursuant to the Business
      Combination Agreement;

     

    WHEREAS, Perceptive and certain other Holders have entered into those certain Subscription Agreements, dated as of February 7, 2021, and the Company has agreed to issue and sell to Perceptive and
      certain other Holders, the number of shares of Common Stock set forth in such Subscription Agreements in exchange for the purchase price set forth therein, on the terms and subject to the conditions set forth therein; and WHEREAS, contingent upon and
      effective as of the Effective Time (as defined in the Business Combination Agreement), the parties to the Prior Agreement desire to terminate the Prior Agreement and to provide for certain rights and obligations included herein and to include the New
      Holders and Perceptive.

     

    NOW, THEREFORE, in consideration of the foregoing, the parties hereby agree as follows:

     

    ARTICLE I

      DEFINITIONS

     

    Section 1.1. Definitions. For purposes of this Agreement,
      the following terms and variations thereof have the meanings set forth below:

     

    “Adverse Disclosure” shall mean any public disclosure of material non-public information, which disclosure, in the good faith judgment of the Chief Executive
      Officer or Chief Financial Officer of the Company, after consultation with outside counsel to the Company, (i) would be required to be made in any Registration Statement or Prospectus in order for the applicable Registration Statement or Prospectus
      not to contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements contained therein (in the case of any prospectus and any preliminary prospectus, in the light of the circumstances under which
      they were made) not misleading, (ii) would not be required to be made at such time if the Registration Statement were not being filed, and (iii) the Company has a bona fide business purpose for not making such information public.

     

    “Agreement” shall have the meaning given in the Preamble.

     

    “Block Trade” means any non-marketed underwritten offering taking the form of a block trade to a financial institution, “qualified institutional buyer” (as
      defined in Rule 144A under the Securities Act) or institutional “accredited” investor (as defined in Rule 501(a) of Regulation D under the Securities Act), bought deal, over-night deal or similar transaction that does not include “road show”
      presentations to potential investors requiring substantial marketing effort from management over multiple days, the issuance of a “comfort letter” by the Company’s auditors, or the issuance of a legal opinion by the Company’s legal counsel.

     

    
      
        

    

    
     “Board” shall mean the Board of Directors of the Company.

     

    “Business Combination” shall mean any merger, share exchange, asset acquisition, stock purchase, recapitalization, reorganization or other similar business
      combination with one or more businesses, involving the Company.

     

    “Business Day” means a day other than Saturday, Sunday or other day on which commercial banks in New York, New York are authorized or required by law to close.

     

    “Change in Control” means the transfer (whether by tender offer, merger, stock purchase, consolidation or other similar transaction), in one transaction or a
      series of related transactions, to a person or group of affiliated persons of the Company’s voting securities if, after such transfer, such person or group of affiliated persons would hold more than 50% of outstanding voting securities of the Company
      (or surviving entity) or would otherwise have the power to control the board of directors of the Company or to direct the operations of the Company.

     

    “Commission” means the Securities and Exchange Commission.

     

    “Common Stock” means the Company’s common stock, par value $0.0001 per share.

     

    “Company” shall have the meaning given in the Preamble.

     

    “Demand Registration” shall have the meaning given in subsection 2.1.1.

     

    “Demand Requesting Holder” shall have the meaning given in subsection 2.1.1.

     

    “Demanding Holders” shall have the meaning given in subsection 2.1.1.

     

    “Effective Time” shall have the meaning set forth in the Business Combination Agreement.

     

    “Exchange Act” shall mean the Securities Exchange Act of 1934, as it may be amended from time to time.

     

    “Form S-1” means a Registration Statement on Form S-1 or any comparable successor form or forms thereto.

     

    “Form S-3” means a Registration Statement on Form S-3 or any comparable successor form or forms thereto.

     

    “Holders” shall have the meaning given in the Preamble.

     

    “Independent Directors” means Todd Wider, Bradley L. Campbell and Saqib Islam.

     

    “Liquidation Event” shall mean any of the following that occur following the Effective Time, (i) the acquisition of the Company by another entity by means of
      any transaction or series of related transactions to which the Company is party (including, without limitation, any stock acquisition, reorganization, sale of voting control, merger or consolidation but excluding any sale of stock for capital raising
      purposes) other than a transaction or series of related transactions in which the holders of the voting securities of the Company outstanding immediately prior to such transaction or series of related transactions retain, immediately after such
      transaction or series of related transactions, as a result of shares in the Company held by such holders prior to such transaction or series of related transactions, at least a majority of the total voting power represented by the outstanding voting
      securities of the Company or such other surviving or resulting entity (or if the Company or such other surviving or resulting entity is a wholly-owned subsidiary immediately following such acquisition, its parent); (ii) a sale, lease, transfer,
      exclusive license or other disposition of all or substantially all of the assets of the Company and its subsidiaries taken as a whole by means of any transaction or series of related transactions, except where such sale, lease, transfer, exclusive
      license or other disposition is to a wholly-owned subsidiary of the Company; or (iii) any liquidation, dissolution or winding up of the Company, whether voluntary or involuntary.

     

    
      2

      
        

    

     

    “Maximum Number of Securities” shall have the meaning given in subsection 2.1.4.

     

    “Misstatement” shall mean an untrue statement of a material fact or an omission to state a material fact required to be stated in a Registration Statement or
      Prospectus, or necessary to make the statements in a Registration Statement or Prospectus in the light of the circumstances under which they were made not misleading.

     

    “New Holders” shall have the meaning given in the Recitals.

     

    “New Registration Statement” shall have the meaning given in subsection 2.3.4.

     

    “Original Holders” shall have the meaning given in the Recitals.

     

    “Perceptive Holders” means the Sponsor and Perceptive.

     

    “Piggyback Registration” shall have the meaning given in subsection 2.3.1.

     

    “Prior Agreement” shall have the meaning given in the Recitals.

     

    “PIPE Shares” means shares of Common Stock purchased pursuant to those certain Subscription Agreements between certain Holders and the Company dated on or
      about February 7, 2021.

     

    “Pro Rata” shall have the meaning given in subsection 2.1.4.

     

    “Prospectus” shall mean the prospectus included in any Registration Statement, as supplemented by any and all prospectus supplements and as amended by any and
      all post-effective amendments and including all material incorporated by reference in such prospectus.

     

    “Registrable Security”, “Registrable Securities” shall mean (a) any outstanding share of Common Stock or any other
      equity security (including the shares of Common Stock issued or issuable upon the exercise of any other equity security) of the Company held by a Holder as of the Closing Date (including, without limitation, the PIPE Shares and any shares of Common
      Stock issued pursuant to the Business Combination Agreement) and (b) any other equity security of the Company issued or issuable with respect to any such share of Common Stock by way of a stock dividend or stock split or in connection with a
      combination of shares, recapitalization, merger, consolidation or reorganization; provided, however, that, as to any particular Registrable Security, such securities shall cease to be Registrable Securities when: (A) a Registration
      Statement with respect to the sale of such securities shall have become effective under the Securities Act and such securities shall have been sold, transferred, disposed of or exchanged in accordance with such Registration Statement; (B) such
      securities shall have been otherwise transferred, new certificates for such securities not bearing a legend restricting further transfer shall have been delivered by the Company to the transferee, and subsequent public distribution of such securities
      shall not require registration under the Securities Act; (C) such securities shall have ceased to be outstanding; or (D) such securities have been sold to, or through, a broker, dealer or underwriter in a public distribution or other public
      securities transaction.

     

    “Registration” shall mean a registration effected by preparing and filing a registration statement or similar document in compliance with the requirements of
      the Securities Act, and the applicable rules and regulations promulgated thereunder, and such registration statement becoming effective.

     

    “Registration Expenses” shall mean the out-of-pocket expenses of a Registration or Underwritten Offering, including, without limitation, the following:

     

    (A)          all registration and filing fees (including fees with respect to filings required to be made with the Financial Industry Regulatory Authority, Inc.) and any securities exchange on which
      the Common Stock is then listed;

     

    
      3

      
        

    

    (B)          fees and expenses of compliance with securities or Blue Sky laws (including reasonable fees and disbursements of counsel for the Underwriters in connection with Blue Sky qualifications
      of Registrable Securities);

     

    (C)          printing, messenger, telephone and delivery expenses;

     

    (D)          reasonable fees and disbursements of counsel for the Company;

     

    (E)          reasonable fees and disbursements of all independent registered public accountants of the Company incurred specifically in connection with such Registration or Underwritten Offering; and

     

    (F)        reasonable fees and expenses of one (1) legal counsel selected by the majority-in-interest of the Demanding Holders or the majority-in interest of the Takedown Requesting Holders
      (including if such Underwritten Takedown is in the form of a Block Trade), as applicable.

     

    “Registration Statement” shall mean any registration statement that covers the Registrable Securities pursuant to the provisions of this Agreement, including
      the Prospectus included in such registration statement, amendments (including post-effective amendments) and supplements to such registration statement, and all exhibits to and all material incorporated by reference in such registration statement.

     

    “Requesting Holder” shall have the meaning given in subsection 2.3.5.

     

    “Resale Shelf Registration Statement” shall have the meaning given in subsection 2.3.1.

     

    “Securities Act” shall mean the Securities Act of 1933, as amended from time to time.

     

    “Selling Holders” means any Holder electing to sell any of its Registrable Securities in a Registration.

     

    “SEC Guidance” shall have the meaning given in subsection 2.3.4.

     

    “Sponsor” shall have the meaning given in the Recitals.

     

    “Takedown Requesting Holder” shall have the meaning given in subsection 2.3.5.

     

    “Transfer” means to, directly or indirectly, sell, transfer, assign, pledge, encumber, hypothecate or similarly dispose of, either voluntarily or
      involuntarily, or to enter into any contract, option or other arrangement or understanding with respect to the sale, transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of, any interest owned by a person or any interest
      (including a beneficial interest) in, or the ownership, control or possession of, any interest owned by a person.

     

    “Underwriter” shall mean a securities dealer who purchases any Registrable Securities as principal in an Underwritten Offering and not as part of such dealer’s
      market-making activities.

     

    “Underwritten Registration” or “Underwritten Offering” shall mean a Registration in which securities of the Company are
      sold to an Underwriter in a firm commitment underwriting for distribution to the public, including for the avoidance of doubt an Underwritten Shelf Takedown.

     

    “Underwritten Shelf Takedown” shall have the meaning given in subsection 2.3.5.

     

    
      4

      
        

    

     ARTICLE II

      REGISTRATION

     

    Section 2.1. Demand Registration.

     

    2.1.1          Request for Registration. Subject to the provisions of subsection 2.1.4 and Section 2.4 hereof, at any time and from time
      to time following the Effective Time (but subject to Article V), (i) New Holders holding at least a majority in interest of the then-outstanding number of Registrable Securities held by all New Holders including or (ii) the Perceptive Holders holding
      at least a majority in interest of the then-outstanding number of Registrable Securities held by all Perceptive Holders (such New Holders or Perceptive Holders, as the case may be, the “Demanding Holders”), may
      make a written demand for Registration of all or part of their Registrable Securities on Form S-3 (or, if Form S-3 is not available to be used by the Company at such time, on Form S-1 or another appropriate form permitting Registration of such
      Registrable Securities for resale by such Demanding Holders), which written demand shall describe the amount and type of securities to be included in such Registration and the intended method(s) of distribution thereof (such written demand a “Demand Registration”). The Company shall, within ten (10) days of the Company’s receipt of the Demand Registration, notify, in writing, all other Holders of Registrable Securities of such demand, and each Holder of
      Registrable Securities who thereafter wishes to include all or a portion of such Holder’s Registrable Securities in a Registration pursuant to a Demand Registration (each such Holder that includes all or a portion of such Holder’s Registrable
      Securities in such Registration, a “Demand Requesting Holder”) shall so notify the Company, in writing, within five (5) days after the receipt by the Holder of the notice from the Company. Upon receipt by the
      Company of any such written notification from a Demand Requesting Holder(s) to the Company, such Demand Requesting Holder(s) shall be entitled to have their Registrable Securities included in a Registration pursuant to a Demand Registration and the
      Company shall effect, as soon thereafter as practicable, but not more than sixty (60) days immediately after the Company’s receipt of the Demand Registration, the Registration of all Registrable Securities requested by the Demanding Holders and
      Demand Requesting Holders pursuant to such Demand Registration; provided that the Company shall not be obligated to effect any Registration under this subsection 2.1.1 if the Demanding Holders and Demand Requesting Holders propose to
      sell Registrable Securities with aggregate proceeds of less than $25,000,000. Under no circumstances shall the Company be obligated to effect more than an aggregate of (i) two (2) Registrations pursuant to a Demand Registration under this subsection

        2.1.1  initiated by New Holders, or (iii) two (2) Registration pursuant to a Demand Registration under this subsection 2.1.1  initiated by Perceptive Holders.

     

    2.1.2          Effective Registration. Notwithstanding the provisions of subsection 2.1.1 above or any other part of this Agreement, a Registration
      pursuant to a Demand Registration shall not count as a Registration unless and until (i) the Registration Statement filed with the Commission with respect to a Registration pursuant to a Demand Registration has been declared effective by the
      Commission and (ii) the Company has complied with all of its obligations under this Agreement with respect thereto; provided, further, however, that if, after such Registration Statement has been declared effective, an
      offering of Registrable Securities in a Registration pursuant to a Demand Registration is subsequently interfered with by any stop order or injunction of the Commission, federal or state court or any other governmental agency, the Registration
      Statement with respect to such Registration shall be deemed not to have been declared effective for purposes of counting Registrations under subsection 2.1.1 above unless and until (i) such stop order or injunction is removed, rescinded or
      otherwise terminated, and (ii) a majority-in-interest of the Demanding Holders initiating such Demand Registration thereafter affirmatively elect to continue with such Registration and accordingly notify the Company in writing, but in no event later
      than five (5) days, of such election; provided, further, however, that the Company shall not be obligated or required to file another Registration Statement until the Registration Statement that has been previously filed with
      respect to a Registration pursuant to a Demand Registration becomes effective or has been terminated.

     

    2.1.3          Underwritten Offering. Subject to the provisions of subsection 2.1.4 and Section 2.4 hereof, if a majority-in-interest of
      the Demanding Holders advise the Company as part of their Demand Registration that the offering of the Registrable Securities pursuant to such Demand Registration shall be in the form of an Underwritten Offering, then the right of such Demanding
      Holder or Demand Requesting Holder (if any) to include its Registrable Securities in such Registration shall be conditioned upon such Holder’s participation in such Underwritten Offering and the inclusion of such Holder’s Registrable Securities in
      such Underwritten Offering to the extent provided herein. All such Holders proposing to distribute their Registrable Securities through an Underwritten Offering under this subsection 2.1.3 shall enter into an underwriting agreement in
      customary form with the Underwriter(s) selected for such Underwritten Offering by a majority-in-interest of the Demanding Holders, such Underwriter(s) to be reasonably acceptable to the Company.

     

    
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    2.1.4          Reduction of Underwritten Offering. If the managing Underwriter or Underwriters in an Underwritten Registration pursuant to a Demand
      Registration, in good faith, advises the Company, the Demanding Holders and the Demand Requesting Holders (if any) in writing that the dollar amount or number of Registrable Securities that the Demanding Holders and the Demand Requesting Holders (if
      any) desire to sell, taken together with all other Common Stock or other equity securities that the Company desires to sell and the Common Stock, if any, as to which a Registration has been requested pursuant to separate written contractual
      piggy-back registration rights held by any other stockholders who desire to sell, exceeds the maximum dollar amount or maximum number of equity securities that can be sold in the Underwritten Offering without adversely affecting the proposed offering
      price, the timing, the distribution method, or the probability of success of such offering (such maximum dollar amount or maximum number of such securities, as applicable, the “Maximum Number of Securities”),
      then the Company shal include in such Underwritten Offering, as follows: (i) first, the Registrable Securities of the Demanding Holders and the Demand Requesting Holders (if any) (pro rata based on the respective number of Registrable Securities that
      each Demanding Holder and Demand Requesting Holder (if any) has requested be included in such Underwritten Registration and the aggregate number of Registrable Securities that the Demanding Holders and Demand Requesting Holders have requested be
      included in such Underwritten Registration (such proportion is referred to herein as “Pro Rata”)) that can be sold without exceeding the Maximum Number of Securities; (ii) second, to the extent that the Maximum
      Number of Securities has not been reached under the foregoing clause (i), Common Stock or other equity securities that the Company desires to sell, which can be sold without exceeding the Maximum Number of Securities; and (iii) third, to the extent
      that the Maximum Number of Securities has not been reached under the foregoing clauses (i) and (ii), Common Stock or other equity securities of other persons or entities that the Company is obligated to register in a Registration pursuant to separate
      written contractual arrangements with such persons and that can be sold without exceeding the Maximum Number of Securities.

     

    2.1.5          Demand Registration Withdrawal. A majority-in-interest of the New Holders or a majority-in-interest of the Perceptive Holders, as the case
      may be, in the case of a Registration under subsection 2.1.1  initiated by the New Holders or the Perceptive Holders, as the case may be, or a majority-in-interest of the Demand Requesting Holders (if any) shall have the right to withdraw
      from a Registration pursuant to such Demand Registration for any or no reason whatsoever upon written notification to the Company and the Underwriter(s) (if any) of their intention to withdraw from such Registration prior to the effectiveness of the
      Registration Statement filed with the Commission with respect to the Registration of their Registrable Securities pursuant to such Demand Registration (or after such Registration Statement has been declared effective and is subsequently interfered
      with by any stop order or injunction of the Commission, federal or state court or any other governmental agency). In the event of such withdrawal the Holders shall be responsible for the Registration Expenses incurred in connection with a
      Registration pursuant to a Demand Registration prior to its withdrawal under this subsection 2.1.5, unless the Holders of a majority of the Registrable Securities agree to forfeit their right to a demand registration pursuant to Section
        2.1.

     

    Section 2.2. Piggyback Registration.

     

    2.2.1          Piggyback Rights. If the Company proposes to file a Registration Statement under the Securities Act with respect to an offering of equity
      securities, or securities or other obligations exercisable or exchangeable for, or convertible into equity securities, for its own account or for the account of stockholders of the Company (other than pursuant to Sections 2.1 and 2.3
      of this Agreement), other than a Registration Statement (i) filed in connection with any employee stock option or other benefit plan, (ii) for an exchange offer or offering of securities solely to the Company’s existing stockholders, (iii) for an
      offering of debt that is convertible into equity securities of the Company, (iv) filed on Form S-4 related to any merger, acquisition or business combination, or (v) for a dividend reinvestment plan, then the Company shall give written notice of such
      proposed filing to all of the Holders of Registrable Securities as soon as practicable but not less than ten (10) days before the anticipated filing date of such Registration Statement, which notice shall (A) describe the amount and type of
      securities to be included in such offering, the intended method(s) of distribution, and the name of the proposed managing Underwriter(s), if any, in such offering, and (B) offer to all of the Holders of Registrable Securities the opportunity to
      register the sale of such number of Registrable Securities as such Holders may request in writing within five (5) days after receipt of such written notice (such Registration a “Piggyback Registration”). The
      Company shall, in good faith, cause such Registrable Securities to be included in such Piggyback Registration and shall use its commercially reasonable efforts to cause the managing Underwriter(s) of a proposed Underwritten Offering to permit the
      Registrable Securities requested by the Holders pursuant to this subsection 2.2.1 to be included in a Piggyback Registration on the same terms and conditions as any similar securities of the Company included in such Registration and to permit
      the sale or other disposition of such Registrable Securities in accordance with the intended method(s) of distribution thereof. Al such Holders proposing to distribute their Registrable Securities through an Underwritten Offering under this subsection

        2.2.1 shall enter into an underwriting agreement in customary form with the Underwriter(s) selected for such Underwritten Offering by the Company.

     

    
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    2.2.2          Reduction of Piggyback Registration. If the managing Underwriter(s) in an Underwritten Registration that is to be a Piggyback Registration,
      in good faith, advises the Company and the Holders of Registrable Securities participating in the Piggyback Registration in writing that the dollar amount or number of shares of Common Stock that the Company desires to sell, taken together with (i)
      the shares of Common Stock, if any, as to which Registration has been demanded pursuant to separate written contractual arrangements with persons or entities other than the Holders of Registrable Securities hereunder, (ii) the Registrable Securities
      as to which registration has been requested pursuant to Section 2.2.1 hereof, and (iii) the shares of Common Stock, if any, as to which Registration has been requested pursuant to separate written contractual piggy-back registration rights of
      other stockholders of the Company, exceeds the Maximum Number of Securities, then:

     

    	

          	(i)	
            If the Registration is undertaken for the Company’s account, the Company shall include in any such Registration (A) first, Common Stock or other equity securities that the Company desires to sell, which can be sold without exceeding the
              Maximum Number of Securities; (B) second, to the extent that the Maximum Number of Securities has not been reached under the foregoing clause (A), the Registrable Securities of Holders exercising their rights to register their Registrable
              Securities pursuant to subsection 2.2.1 hereof, Pro Rata, based on the respective number of Registrable Securities that each Holder has so requested, which can be sold without exceeding the Maximum Number of Securities; and (C) third,
              to the extent that the Maximum Number of Securities has not been reached under the foregoing clauses (A) and (B), Common Stock, if any, as to which Registration has been requested pursuant to written contractual piggy-back registration rights
              of other stockholders of the Company, which can be sold without exceeding the Maximum Number of Securities; and

          

     

    	

          	(ii)	
            If the Registration is pursuant to a request by persons or entities other than the Holders of Registrable Securities, then the Company shall include in any such Registration (A) first, Common Stock or other equity securities, if any, of
              such requesting persons or entities, other than the Holders of Registrable Securities, which can be sold without exceeding the Maximum Number of Securities; (B) second, to the extent that the Maximum Number of Securities has not been reached
              under the foregoing clause (A), the Registrable Securities of Holders exercising their rights to register their Registrable Securities pursuant to subsection 2.2.1, Pro Rata based on the respective number of Registrable Securities
              that each Holder has requested, which can be sold without exceeding the Maximum Number of Securities; (C) third, to the extent that the Maximum Number of Securities has not been reached under the foregoing clauses (A) and (B), Common Stock or
              other equity securities that the Company desires to sell, which can be sold without exceeding the Maximum Number of Securities; and (D) fourth, to the extent that the Maximum Number of Securities has not been reached under the foregoing
              clauses (A), (B) and (C), Common Stock or other equity securities for the account of other persons or entities that the Company is obligated to register pursuant to separate written contractual arrangements with such persons or entities,
              which can be sold without exceeding the Maximum Number of Securities.

          

     

    2.2.3          Piggyback Registration Withdrawal. Any Holder of Registrable Securities shall have the right to withdraw from a Piggyback Registration for
      any or no reason whatsoever upon written notification to the Company and the Underwriter or Underwriters (if any) of his, her or its intention to withdraw from such Piggyback Registration prior to the effectiveness of the Registration Statement filed
      with the Commission with respect to such Piggyback Registration, or, if such Piggyback Registration is in connection with an underwritten offering pursuant to an effective shelf registration statement, then prior to the public announcement of such
      offering. The Company (whether on its own good faith determination or as the result of a request for withdrawal by persons pursuant to separate written contractual obligations) may withdraw a Registration Statement filed with the Commission in
      connection with a Piggyback Registration at any time prior to the effectiveness of such Registration Statement. Notwithstanding anything to the contrary in this Agreement, the Company shall be responsible for the Registration Expenses incurred in
      connection with the Piggyback Registration prior to its withdrawal under this subsection 2.2.3.

     

    
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    2.2.4          Unlimited Piggyback Registration Rights. For purposes of clarity, any Registration effected pursuant to Section 2.2 hereof shall not
      be counted as a Registration pursuant to a Demand Registration effected under Section 2.1 hereof.

     

    2.2.5          Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section

        2.2 prior to the effectiveness of such registration whether or not any Holder of Registrable Securities has elected to include securities in such registration.

     

    Section 2.3. Resale Shelf Registration Rights

     

    2.3.1          Registration Statement Covering Resale of Registrable Securities. The Company shall prepare and file or cause to be prepared and filed with
      the Commission, no later than forty-five (45) days following the Closing Date (the “Filing Deadline”), a Registration Statement for an offering to be made on a continuous basis pursuant to Rule 415 of the
      Securities Act or any successor thereto registering the resale from time to time by Holders of all of the Registrable Securities held by the Holders (the “Resale Shelf Registration Statement”). The Resale Shelf
      Registration Statement shall be on Form S-3 (or, if Form S-3 is not available to be used by the Company at such time, on Form S-1 or another appropriate form permitting Registration of such Registrable Securities for resale). If the Resale Shelf
      Registration Statement is initially filed on Form S-1 and thereafter the Company becomes eligible to use Form S-3 for secondary sales, the Company shall, as promptly as practicable, cause such Resale Shelf Registration Statement to be amended, or
      shall file a new replacement Resale Shelf Registration Statement, such that the Resale Shelf Registration Statement is on Form S-3. The Company shall use commercially reasonable efforts to cause the Resale Shelf Registration Statement to be declared
      effective as soon as possible after filing; provided, however, that the Company’s obligations to include the Registrable Securities held by a Holder in the Resale Shelf Registration Statement are contingent upon such Holder furnishing
      in writing to the Company such information regarding the Holder, the securities of the Company held by the Holder and the intended method of disposition of the Registrable Securities as shall be reasonably requested by the Company to effect the
      registration of the Registrable Securities, and the Holder shall execute such documents in connection with such registration as the Company may reasonably request that are customary of a selling stockholder in similar situations. Once effective, the
      Company shall use commercially reasonable efforts to keep the Resale Shelf Registration Statement and Prospectus included therein continuously effective and to be supplemented and amended to the extent necessary to ensure that such Registration
      Statement is available or, if not available, to ensure that another Registration Statement is available, under the Securities Act at all times until the earliest of (i) the date on which all Registrable Securities and other securities covered by such
      Registration Statement have been disposed of in accordance with the intended method(s) of distribution set forth in such Registration Statement and (ii) the date on which all Registrable Securities and other securities covered by such Registration
      Statement have ceased to be Registrable Securities. The Registration Statement filed with the Commission pursuant to this subsection 2.3.1 shall contain a prospectus in such form as to permit any Holder to sell such Registrable Securities
      pursuant to Rule 415 under the Securities Act (or any successor or similar provision adopted by the Commission then in effect) at any time beginning on the effective date for such Registration Statement (subject to lock-up restrictions provided in Section

        5.1 of this Agreement), and shall provide that such Registrable Securities may be sold pursuant to any method or combination of methods legally available to, and requested by, Holders.

     

    2.3.2          Notification and Distribution of Materials. The Company shall notify the Holders in writing of the effectiveness of the Resale Shelf
      Registration Statement as soon as practicable, and in any event within one (1) Business Day after the Resale Shelf Registration Statement becomes effective, and shall furnish to them, without charge, such number of copies of the Resale Shelf
      Registration Statement (including any amendments, supplements and exhibits), the Prospectus contained therein (including each preliminary prospectus and all related amendments and supplements) and any documents incorporated by reference in the Resale
      Shelf Registration Statement or such other documents as the Holders may reasonably request in order to facilitate the sale of the Registrable Securities in the manner described in the Resale Shelf Registration Statement.

     

    2.3.3          Amendments and Supplements. Subject to the provisions of Section 2.3.1 above, the Company shall promptly prepare and file with the
      Commission from time to time such amendments and supplements to the Resale Shelf Registration Statement and Prospectus used in connection therewith as may be necessary to keep the Resale Shelf Registration Statement effective and to comply with the
      provisions of the Securities Act with respect to the disposition of all the Registrable Securities. If any Resale Shelf Registration Statement filed pursuant to Section 2.3.1 is filed on Form S-3 and thereafter the Company becomes ineligible
      to use Form S-3 for secondary sales, the Company shall promptly notify the Holders of such ineligibility and use its commercially reasonable efforts to file a shelf registration on an appropriate form as promptly as practicable to replace the shelf
      registration statement on Form S-3 and have such replacement Resale Shelf Registration Statement declared effective as promptly as practicable and to cause such replacement Resale Shelf Registration Statement to remain effective, and to be
      supplemented and amended to the extent necessary to ensure that such Resale Shelf Registration Statement is available or, if not available, that another Resale Shelf Registration Statement is available, for the resale of all the Registrable
      Securities held by the Holders until all such Registrable Securities have ceased to be Registrable Securities; provided, however, that at any time the Company once again becomes eligible to use Form S-3, the Company shall cause such
      replacement Resale Shelf Registration Statement to be amended, or shall file a new replacement Resale Shelf Registration Statement, such that the Resale Shelf Registration Statement is once again on Form S-3.

     

    
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    2.3.4          SEC Cutback. Notwithstanding the registration obligations set forth in this Section 2.3, in the event the Commission informs the
      Company that all of the Registrable Securities cannot, as a result of the application of Rule 415, be registered for resale as a secondary offering on a single registration statement, the Company agrees to promptly (i) inform each of the Holders
      thereof and use its commercially reasonable efforts to file amendments to the Resale Shelf Registration Statement as required by the Commission and/or (ii) withdraw the Resale Shelf Registration Statement and file a new registration statement (a “New Registration Statement”) on Form S-3, or if Form S-3 is not then available to the Company for such registration statement, on such other form available to register for resale the Registrable Securities as a
      secondary offering; provided, however, that prior to filing such amendment or New Registration Statement, the Company shall use its commercially reasonable efforts to advocate with the Commission for the registration of all of the
      Registrable Securities in accordance with any publicly -available written or oral guidance, comments, requirements or requests of the Commission staff (the “SEC Guidance”). Notwithstanding any other provision
      of this Agreement, if any SEC Guidance sets forth a limitation on the number of Registrable Securities permitted to be registered on a particular Registration Statement as a secondary offering (and notwithstanding that the Company used diligent
      efforts to advocate with the Commission for the registration of all or a greater number of Registrable Securities), unless otherwise directed in writing by a Holder as to further limit its Registrable Securities to be included on the Registration
      Statement, the number of Registrable Securities to be registered on such Registration Statement will be reduced on a Pro Rata basis based on the total number of Registrable Securities held by the Holders, subject to a determination by the Commission
      that certain Holders must be reduced first based on the number of Registrable Securities held by such Holders. In the event the Company amends the Resale Shelf Registration Statement or files a New Registration Statement, as the case may be, under
      clauses (i) or (ii) above, the Company will use its commercially reasonable efforts to file with the Commission, as promptly as allowed by Commission or SEC Guidance provided to the Company or to registrants of securities in general, one or more
      registration statements on Form S-3 or such other form available to register for resale those Registrable Securities that were not registered for resale on the Resale Shelf Registration Statement, as amended, or the New Registration Statement.

     

    2.3.5          Underwritten Shelf Takedown. At any time and from time to time after a Resale Shelf Registration Statement has been declared effective by
      the Commission, the Holders may request to sell all or any portion of the Registrable Securities in an underwritten offering that is registered pursuant to the Resale Shelf Registration Statement (each, an “Underwritten

        Shelf Takedown”); provided, however, that the Company shall only be obligated to effect an Underwritten Shelf Takedown if such offering shall include securities with a total offering price (including piggyback securities and
      before deduction of underwriting discounts or commissions) reasonably expected to exceed, in the aggregate, $25,000,000. All requests for Underwritten Shelf Takedowns shall be made by giving written notice to the Company at least ten (10) days prior
      to the public announcement of such Underwritten Shelf Takedown, which shall specify the approximate number of Registrable Securities proposed to be sold in the Underwritten Shelf Takedown and the expected price range (net of underwriting discounts
      and commissions) of such Underwritten Shelf Takedown. Except in the case of a requested Underwritten Shelf Takedown in the form of a Block Trade, following receipt of a request for an Underwritten Shelf Takedown, the Company shall promptly notify the
      other Holders of the request and of their right to participate in the Underwritten Shelf Takedown, which shall specify the anticipated public announcement date. The Company shall include in any Underwritten Shelf Takedown the securities requested to
      be included by any Holder (each a “Takedown Requesting Holder”) at least 48 hours prior to the anticipated public announcement date of such Underwritten Shelf Takedown set forth in the Company notice pursuant
      to written contractual piggyback registration rights of such Holder (including those set forth herein). All such Holders proposing to distribute their Registrable Securities through an Underwritten Shelf Takedown under this subsection 2.3.5
      shall enter into an underwriting agreement in customary form with the Underwriter(s) selected for such Underwritten Offering by the majority-in-interest of the Takedown Requesting Holders initiating the Underwritten Shelf Takedown.

     

    
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    2.3.6          Reduction of Underwritten Shelf Takedown. If the managing Underwriter(s) in an Underwritten Shelf Takedown, in good faith, advise(s) the
      Company and the Takedown Requesting Holders in writing that the dollar amount or number of Registrable Securities that the Takedown Requesting Holders desire to sell, taken together with all other shares of the Common Stock or other equity securities
      that the Company desires to sell, exceeds the Maximum Number of Securities, then the Company shall include in such Underwritten Shelf Takedown, as follows: (i) first, the Registrable Securities of the Takedown Requesting Holders, on a Pro Rata basis,
      that can be sold without exceeding the Maximum Number of Securities; and (ii) second, to the extent that the Maximum Number of Securities has not been reached under the foregoing clause (i), the Common Stock or other equity securities that the
      Company desires to sell, which can be sold without exceeding the Maximum Number of Securities.

     

    2.3.7          Registrations effected pursuant to this Section 2.3 shall not be counted as Demand Registrations effected pursuant to Section 2.1.
      Under no circumstances shall the Company be obligated to effect more than an aggregate of four (4) Underwritten Shelf Takedowns in any 12-month period.

     

    2.3.8          Block Trades. If the Company shall receive a request from a Holder or Holders of Registrable Securities with an estimated market value of at
      least $25,000,000 that the Company effect the sale of al or any portion of such Registrable Securities in an Underwritten Shelf Takedown in the form of a Block Trade, then the Company shall, as expeditiously as possible, cooperate and effect the
      offering in such Block Trade of the Registrable Securities for which such requesting Holder has requested such offering, without giving any effect to any required notice periods or delivery of notices to any other Holders. Any offering conducted as a
      Block Trade will not count as an Underwritten Shelf Takedown for the purposes of Section 2.3.7.

     

    Section 2.4. Restrictions on Registration Rights. Notwithstanding anything to the contrary
      contained herein, the Company shall not be obligated to (but may, at its sole option) file a Registration Statement pursuant to a Demand Registration request made under Section 2.1  during the period starting with the date sixty (60) days
      prior to the Company’s good faith estimate of the date of the filing of, and ending on a date one hundred and twenty (120) days after the effective date of, a Company initiated Registration and provided that the Company has delivered written notice
      to the Holders prior to receipt of a Demand Registration pursuant to subsection 2.1.1 and that the Company continues to actively employ, in good faith, commercially reasonable efforts to cause the applicable Registration Statement to become
      effective.

     

    ARTICLE III

      COMPANY PROCEDURES

     

    Section 3.1. General Procedures. If at any time on or after the Effective Time the Company is
      required to effect the Registration of Registrable Securities, the Company shall use its commercially reasonable efforts to effect such Registration to permit the sale of such Registrable Securities in accordance with the intended plan of
      distribution thereof, and pursuant thereto the Company shall, as expeditiously as possible:

     

    3.1.1          prepare and file with the Commission as soon as practicable a Registration Statement with respect to such Registrable Securities and use its
      commercially reasonable efforts to cause such Registration Statement to become effective and remain effective until all Registrable Securities covered by such Registration Statement have been sold;

     

    3.1.2          prepare and file with the Commission such amendments and post-effective amendments to the Registration Statement, and such supplements to the
      Prospectus, as may be reasonably requested by the Holders or any Underwriter of Registrable Securities or as may be required by the rules, regulations or instructions applicable to the registration form used by the Company or by the Securities Act or
      rules and regulations thereunder to keep the Registration Statement effective until all Registrable Securities covered by such Registration Statement are sold in accordance with the intended plan of distribution set forth in such Registration
      Statement or supplement to the Prospectus;

     

    
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     3.1.3          prior to filing a Registration Statement or Prospectus, or any amendment or supplement thereto, furnish without charge to the Underwriter(s), if
      any, and the Holders of Registrable Securities included in such Registration, and such Holders’ legal counsel, copies of such Registration Statement as proposed to be filed, each amendment and supplement to such Registration Statement (in each case
      including all exhibits thereto and documents incorporated by reference therein), the Prospectus included in such Registration Statement (including each preliminary Prospectus), and such other documents as the Underwriters and the Holders of
      Registrable Securities included in such Registration or the legal counsel for any such Holders may request in order to facilitate the disposition of the Registrable Securities owned by such Holders;

     

    3.1.4          prior to any public offering of Registrable Securities, use its commercially reasonable efforts to (i) register or qualify the Registrable
      Securities covered by the Registration Statement under such securities or “Blue Sky” laws of such jurisdictions in the United States as the Holders of Registrable Securities included in such Registration Statement (in light of their intended plan of
      distribution) may request and (ii) take such action necessary to cause such Registrable Securities covered by the Registration Statement to be registered with or approved by such other governmental authorities as may be necessary by virtue of the
      business and operations of the Company and do any and all other acts and things that may be necessary or advisable to enable the Holders of Registrable Securities included in such Registration Statement to consummate the disposition of such
      Registrable Securities in such jurisdictions; provided, however, that the Company shall not be required to qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify or take any action to
      which it would be subject to general service of process or taxation in any such jurisdiction where it is not then otherwise so subject;

     

    3.1.5          cause all such Registrable Securities to be listed on each securities exchange or automated quotation system on which similar securities issued by
      the Company are then listed;

     

    3.1.6          provide a transfer agent and registrar for all such Registrable Securities no later than the effective date of such Registration Statement;

     

    3.1.7          advise each seller of such Registrable Securities, promptly after it shall receive notice or obtain knowledge thereof, of the issuance of any stop
      order by the Commission suspending the effectiveness of such Registration Statement or the initiation or threatening of any proceeding for such purpose and promptly use its commercially reasonable efforts to prevent the issuance of any stop order or
      to obtain its withdrawal if such stop order should be issued;

     

    3.1.8          advise each Holder of Registrable Securities covered by such Registration Statement, promptly after the Company receives notice thereof, of the
      time when such registration statement has been declared effective or a supplement to any Prospectus forming a part of such registration statement has been filed;

     

    3.1.9          at least five (5) days prior to the filing of any Registration Statement or Prospectus or any amendment or supplement to such Registration
      Statement or Prospectus, furnish a draft copy thereof to each seller of such Registrable Securities or its counsel;

     

    3.1.10          notify the Holders at any time when a Prospectus relating to such Registration Statement is required to be delivered under the Securities Act, of
      the happening of any event as a result of which the Prospectus included in such Registration Statement, as then in effect, includes a Misstatement, and then to correct such Misstatement as set forth in Section 3.4 hereof;

     

    3.1.11          permit a representative of the Holders, the Underwriter(s), if any, and any attorney or accountant retained by such Holders or Underwriter(s) to
      participate, at each such person’s own expense (except as otherwise set forth herein), in the preparation of the Registration Statement, and cause the Company’s officers, directors and employees to supply all information reasonably requested by any
      such representative, Underwriter(s), attorney or accountant in connection with the Registration; provided, however, that such representatives or Underwriter(s) enter into a confidentiality agreement, in form and substance reasonably
      satisfactory to the Company, prior to the release or disclosure of any such information;

     

    
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     3.1.12          obtain a “cold comfort” letter from the Company’s independent registered public accountants in the event of an Underwritten Registration, in
      customary form and covering such matters of the type customarily covered by “cold comfort” letters as the managing Underwriter(s) may reasonably request, and reasonably satisfactory to a majority-in-interest of the participating Holders and such
      managing Underwriter;

     

    3.1.13          on the date the Registrable Securities are delivered for sale pursuant to such Registration, if requested by the Underwriter(s), if any, obtain an
      opinion and negative assurance letter, dated such date, of counsel representing the Company for the purposes of such Registration addressed to the Underwriter(s) covering such legal matters with respect to the Registration in respect of which such
      opinion and negative assurance letter are being given as are customarily included in such opinions and negative assurance letters;

     

    3.1.14          in the event of any Underwritten Offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form,
      with the managing Underwriter(s) of such offering;

     

    3.1.15          make available to its security holders, as soon as reasonably practicable, an earnings statement covering the period of at least twelve (12)
      months beginning with the first day of the Company’s first full calendar quarter after the effective date of the Registration Statement which satisfies the provisions of Section 11(a) of the Securities Act and Rule 158 thereunder (or any
      successor rule promulgated thereafter by the Commission);

     

    3.1.16          if a Registration, including an Underwritten Offering, involves the Registration of Registrable Securities involving gross proceeds in excess of
      $50,000,000, use its commercially reasonable efforts to make available senior executives of the Company to participate in customary “road show” presentations that may be reasonably requested by the Underwriter(s) in any Underwritten Offering; and

     

    3.1.17          otherwise, in good faith, cooperate reasonably with, and take such customary actions as may reasonably be requested by the Holders, in connection
      with such Registration.

     

    Section 3.2. Registration Expenses. Except as set forth in Section 2.1.5, all
      Registration Expenses shal be borne by the Company. It is acknowledged by the Holders that the Holders shall bear all incremental selling expenses relating to the sale of Registrable Securities, such as Underwriters’ commissions and discounts,
      brokerage fees, Underwriter marketing costs and, other than as set forth in the definition of “Registration Expenses,” all reasonable fees and expenses of any legal counsel representing the Holders.

     

    Section 3.3. Requirements for Participation in Underwritten Offerings. No person may participate
      in any Underwritten Offering for equity securities of the Company pursuant to a Registration initiated by the Company hereunder unless such person (i) agrees to sell such person’s securities on the basis provided in any underwriting arrangements
      approved by the Company and (ii) completes and executes all customary questionnaires, powers of attorney, indemnities, lock-up agreements, underwriting agreements and other customary documents as may be reasonably required under the terms of such
      underwriting arrangements.

     

    Section 3.4. Suspension of Sales; Adverse Disclosure. Upon receipt of written notice from the
      Company that a Registration Statement or Prospectus contains a Misstatement, each of the Holders shall forthwith discontinue disposition of Registrable Securities until he, she or it has received copies of a supplemented or amended Prospectus
      correcting the Misstatement or until he, she, or it is advised in writing by the Company that the use of the Prospectus may be resumed, provided that the Company hereby covenants to prepare and file any required supplement or amendment correcting any
      Misstatement promptly after the time of such notice and, if necessary, to request the immediate effectiveness thereof. If the filing, initial effectiveness or continued use of a Registration Statement or Prospectus included in any Registration
      Statement at any time (a) would require the Company to make an Adverse Disclosure, (b) would require the inclusion in such Registration Statement of financial statements that are unavailable to the Company for reasons beyond the Company’s control, or
      (c) in the good faith judgment of the Board, would be materially detrimental to the Company, the Company shall have the right to defer the filing, initial effectiveness or continued use of any Registration Statement pursuant to (a), (b) or (c) for a
      period of not more than ninety (90) days and the Company shall not defer any such filing, initial effectiveness or use of a Registration Statement pursuant to this Section 3.4 more than twice (in each case counting deferrals initiated
      pursuant to (a), (b) and (c) in the aggregate) in any 12-month period. In the event the Company exercises its rights under the preceding sentence, the Holders agree to suspend, immediately upon their receipt of the notice referred to above, their use
      of the Prospectus relating to any Registration in connection with any sale or offer to sell Registrable Securities.

     

    
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     Section 3.5. Reporting Obligations. As long as any Holder shall own Registrable Securities, the
      Company, at all times while it shall be a reporting company under the Exchange Act, covenants to file timely (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the Company after
      the date hereof pursuant to Sections 13(a) or  15(d) of the Exchange Act and to promptly furnish the Holders with true and complete copies of all such filings. The Company further covenants that it shall take such further action as any Holder may
      reasonably request, all to the extent required from time to time to enable such Holder to sell shares of Common Stock held by such Holder without registration under the Securities Act within the limitation of the exemptions provided by Rule 144
      promulgated under the Securities Act (or any successor rule promulgated thereafter by the Commission), including providing any customary legal opinions as reasonably requested. Upon the request of any Holder, the Company shall deliver to such Holder
      a written certification of a duly authorized officer as to whether it has complied with such requirements.

     

     
    Section 3.6. Limitations on Registration Rights. Other than the registration rights granted to
      the purchasers under the Subscription Agreements to be entered into on about the date hereof with certain investors relating to the private placement of shares of Common Stock as provided for in the Business Combination Agreement, the Company shall
      not hereafter enter into any agreement with respect to its securities which is inconsistent with or violates the rights granted to the Holders of Registrable Securities in this Agreement and in the event of any conflict between any such agreement or
      agreements and this Agreement, the terms of this Agreement shall prevail.

     

    ARTICLE IV

      INDEMNIFICATION AND CONTRIBUTION

     

    Section 4.1. Indemnification

     

    4.1.1          The Company agrees to indemnify, to the extent permitted by law, each Holder of Registrable Securities, its officers and directors and agents and
      each person who controls such Holder (within the meaning of the Securities Act) against all losses, claims, damages, liabilities and expenses (including attorneys’ fees) caused by any untrue or alleged untrue statement of material fact contained in
      any Registration Statement, Prospectus or preliminary Prospectus or any amendment thereof or supplement thereto or any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein not
      misleading, except insofar as the same are caused by or contained in any information furnished in writing to the Company by such Holder expressly for use therein. The Company shall indemnify the Underwriter(s), their officers and directors and each
      person who controls (within the meaning of the Securities Act) such Underwriter(s) to the same extent as provided in the foregoing with respect to the indemnification of the Holder.

     

    4.1.2          In connection with any Registration Statement in which a Holder of Registrable Securities is participating, such Holder shall furnish to the
      Company in writing such information and affidavits as the Company reasonably requests for use in connection with any such Registration Statement or Prospectus and, to the extent permitted by law, shall indemnify the Company, its directors and
      officers and agents and each person who controls (within the meaning of the Securities Act) the Company against any losses, claims, damages, liabilities and expenses (including without limitation reasonable attorneys’ fees) resulting from any untrue
      statement of material fact contained in the Registration Statement, Prospectus or preliminary Prospectus or any amendment thereof or supplement thereto or any omission of a material fact required to be stated therein or necessary to make the
      statements therein not misleading, but only to the extent that such untrue statement or omission is contained in any information or affidavit so furnished in writing by such Holder expressly for use therein; provided, however, that
      the obligation to indemnify shall be several, not joint and several, among such Holders of Registrable Securities, and the liability of each such Holder of Registrable Securities shall be in proportion to and limited to the net proceeds actually
      received by such Holder from the sale of Registrable Securities pursuant to such Registration Statement. The Holders of Registrable Securities shall indemnify the Underwriter(s), their officers, directors and each person who controls (within the
      meaning of the Securities Act) such Underwriter(s) to the same extent as provided in the foregoing with respect to indemnification of the Company.

     

    
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     4.1.3          Any person entitled to indemnification herein shall (i) give prompt written notice to the indemnifying party of any claim with respect to which it
      seeks indemnification (provided, however, that the failure to give prompt notice shall not impair any person’s right to indemnification hereunder to the extent such failure has not materially prejudiced the indemnifying party) and (ii)
      unless in such indemnified party’s reasonable judgment a conflict of interest between such indemnified and indemnifying parties may exist with respect to such claim, permit such indemnifying party to assume the defense of such claim with counsel
      reasonably satisfactory to the indemnified party. If such defense is assumed, the indemnifying party shall not be subject to any liability for any settlement made by the indemnified party without its consent (but such consent shall not be
      unreasonably withheld, conditioned or delayed). An indemnifying party who is not entitled to, or elects not to, assume the defense of a claim shall not be obligated to pay the fees and expenses of more than one counsel for all parties indemnified by
      such indemnifying party with respect to such claim, unless in the reasonable judgment of any indemnified party a conflict of interest may exist between such indemnified party and any other of such indemnified parties with respect to such claim. No
      indemnifying party shall, without the consent of the indemnified party, consent to the entry of any judgment or enter into any settlement which cannot be settled in all respects by the payment of money (and such money is so paid by the indemnifying
      party pursuant to the terms of such settlement) or which settlement does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from al liability in respect to such claim or
      litigation.

     

    4.1.4          The indemnification provided for under this Agreement shall remain in full force and effect regardless of any investigation made by or on behalf of
      the indemnified party or any officer, director or controlling person of such indemnified party and shall survive the transfer of securities. The Company and each Holder of Registrable Securities participating in an offering also agrees to make such
      provisions as are reasonably requested by any indemnified party for contribution (pursuant to subsection 4.1.5) to such party in the event the Company’s or such Holder’s indemnification is unavailable for any reason.

     

    4.1.5          If the indemnification provided under Section 4.1 hereof from the indemnifying party is unavailable or insufficient to hold harmless an
      indemnified party in respect of any losses, claims, damages, liabilities and expenses referred to herein, then the indemnifying party, in lieu of indemnifying the indemnified party, shall contribute to the amount paid or payable by the indemnified
      party as a result of such losses, claims, damages, liabilities and expenses in such proportion as is appropriate to reflect the relative fault of the indemnifying party and the indemnified party, as well as any other relevant equitable
      considerations. The relative fault of the indemnifying party and indemnified party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact or
      omission or alleged omission to state a material fact, was made by, or relates to information supplied by, such indemnifying party or indemnified party, and the indemnifying party’s and indemnified party’s relative intent, knowledge, access to
      information and opportunity to correct or prevent such action; provided, however, that the liability of any Holder under this subsection 4.1.5 shall be limited to the amount of the net proceeds actually received by such Holder
      in such offering giving rise to such liability. The amount paid or payable by a party as a result of the losses or other liabilities referred to above shall be deemed to include, subject to the limitations set forth in subsections 4.1.1, 4.1.2
      and 4.1.3 above, any legal or other fees, charges or expenses reasonably incurred by such party in connection with any investigation or proceeding. The parties hereto agree that it would not be just and equitable if contribution pursuant to
      this subsection 4.1.5 were determined by pro rata allocation or by any other method of allocation, which does not take account of the equitable considerations referred to in this subsection 4.1.5. No person guilty of fraudulent
      misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution pursuant to this subsection 4.1.5 from any person who was not guilty of such fraudulent misrepresentation.

     

    4.1.6          Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in any underwriting agreement
      entered into in connection with an underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control.

     

    
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     ARTICLE V

      LOCK-UP

     

    Section 5.1. Lock-Up. Except as permitted by Section 5.2, each Holder shall not Transfer
      any shares of Common Stock, (including, without limitation, the PIPE Shares, any shares of Common Stock issued pursuant to the Business Combination Agreement, and any other shares of Common Stock), beneficially owned or owned of record by such Holder
      until the date that is 180 days from the Closing Date (the “Lock-up Period”).

     

    Section 5.2. Exceptions. The provisions of Section 5.1 shall not apply to:

     

    5.2.1          transactions relating to shares of Common Stock acquired in open market transactions;

     

    5.2.2          Transfers of shares of Common Stock or any security convertible into or exercisable or exchangeable for Common Stock as a bona fide gift or
      charitable contribution;

     

    5.2.3          Transfers of shares of Common Stock to a trust, or other entity formed for estate planning purposes for the primary benefit of the spouse, domestic
      partner, parent, sibling, child or grandchild of the undersigned or any other person with whom the undersigned has a relationship by blood, marriage or adoption not more remote than first cousin;

     

    5.2.4          Transfers by will or intestate succession upon the death of the undersigned;

     

    5.2.5          the Transfer of shares of Common Stock pursuant to a qualified domestic order, court order or in connection with a divorce settlement;

     

    5.2.6          if the Holder is a corporation, partnership (whether general, limited or otherwise), limited liability company, trust or other business entity, (i)
      Transfers to another corporation, partnership, limited liability company, trust or other business entity that controls, is controlled by or is under common control or management with the Holder, or (ii) distributions of shares of Common Stock to
      partners, limited liability company members or stockholders of the Holder, including, for the avoidance of doubt, where the Holder is a partnership, to its general partner or a successor partnership or fund, or any other funds managed by such
      partnership;

     

    5.2.7          if the Holder is a trust, Transfers to a trustor or beneficiary of the trust or to the estate of a beneficiary of such trust;

     

    5.2.8          Transfers to the Company’s officers, directors or their affiliates;

     

    5.2.9          Transfers to a nominee or custodian of a person or entity to whom a disposition or transfer would be permissible under Sections 5.2.2
      through 5.2.8;

     

    5.2.10       pledges of shares of Common Stock or other Registrable Securities as security or collateral in connection with any borrowing or the incurrence of any
      indebtedness by any Holder; provided, however, that such borrowing or incurrence of indebtedness is secured by a portfolio of assets or equity interests issued by multiple issuers;

     

    5.2.11          Transfers pursuant to a bona fide third-party tender offer, merger, stock sale, recapitalization, consolidation or other transaction involving a
      Change in Control of the Company; provided, however, that in the event that such tender offer, merger, recapitalization, consolidation or other such transaction is not completed, the Common Stock subject to this Agreement shall remain
      subject to this Agreement;

     

    5.2.12         the establishment of a trading plan pursuant to Rule 10b5-1 promulgated under the Exchange Act; provided, however, that such plan
      does not provide for the Transfer of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock during the Lock-Up Period;

     

    5.2.13          Transfers of shares of Common Stock to the Company in connection with the repurchase of the undersigned’s shares in connection with the
      termination of the undersigned’s employment with the Company pursuant to contractual agreements with the Company;

     

    5.2.14          Transfers of shares of Common Stock to satisfy tax withholding obligations in connection with the exercise of options to purchase shares of Common
      Stock or the vesting of stock-based awards;

     

    
      15

      
        

    

     5.2.15        Transfers of shares of Common Stock in payment on a “net exercise” or “cashless” basis of the exercise or purchase price with respect to the
      exercise of options to purchase shares of Common Stock;

     

    5.2.16          Transfers to the Company through the exercise of a stock option granted under a stock incentive plan or stock purchase plan or a warrant, and the
      receipt by the Holder from the Company of shares of Common Stock upon any such exercise, insofar as such option or warrant expires during the Lock-Up Period; provided that the underlying shares shall continue to be subject to the restrictions on
      transfer set forth in this Agreement;

     

    provided, however, that in the case of any Transfer pursuant to Sections 5.2.2 through 5.2.10, each donee, distribute, pledgee or other transferee shall agree in writing, in form and
      substance reasonably satisfactory to the Company, to be bound by the provisions of this Agreement.

     

    Section 5.3. Release of Lock-Up Restrictions. Notwithstanding the other provisions set forth
      herein, the Board may, in its sole discretion, determine to waive, amend, or repeal the restrictions set forth in Section 5.1 above, whether in whole or in part; provided, that any such waiver, amendment or repeal shall (i) not make
      such restrictions more restrictive or apply for a longer period of time and (ii) require the unanimous approval of the directors present at any duly called meeting at which a quorum is present.

     

    ARTICLE VI

      TERMINATION

     

    Section 6.1. Termination. This Agreement shall terminate upon the earliest to occur of: (i) the
      termination of the Business Combination Agreement, (ii) the date on which neither the Holders nor any of their permitted assignees hold any Registrable Securities, and (iii) a Liquidation Event.

     

    Section 6.2. Effect of Business Combination Termination. In the event of a termination of this
      Agreement as a result of the termination of the Business Combination Agreement, this Agreement shall become void and the Prior Agreement shall continue in full force and effect; this Agreement shall only become effective at the Effective Time, and
      prior to such date this Agreement shall be of no force and effect.

     

    ARTICLE VII

      GENERAL PROVISIONS

     

    Section 7.1. Notices. All notices, requests, claims, demands and other communications hereunder
      shall be in writing and shall be given (and shall be deemed to have been duly given upon receipt) by delivery in person, by e-mail or by registered or certified mail (postage prepaid, return receipt requested) to the respective parties at the
      following addresses or e-mail addresses (or at such other address or email address for a party as shall be specified in a notice given in accordance with this Section 7.1):

     

    If to the Company, to it at:

     

    Nautilus Biotechnology, Inc.

    425 Pontius Ave. N., Ste. 202

    Seattle, WA 98102

    Attention: Sujal Patel, Chief Executive Officer

    Email: smpatel@nautilus.bio

     

    with a copy (which shall not constitute notice) to:

     

    Wilson Sonsini Goodrich & Rosati

    650 Page Mill Road

    Palo Alto, CA 94304

    Attention: Robert F. Kornegay

    Email: rkornegay@wsgr.com

     

    
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    If to a Holder, to the address or email address set forth for Holder on the signature page hereof.

     

    Section 7.2. Severability. If any term or other provision of this Agreement is invalid, illegal
      or incapable of being enforced by any rule of law or public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions contemplated
      hereby is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this
      Agreement so as to effect the original intent of the parties as closely as possible in a mutually acceptable manner in order that the transactions contemplated hereby be consummated as originally contemplated to the fullest extent possible.

     

    Section 7.3. Entire Agreement; Assignment. This Agreement constitutes the entire agreement among
      the parties with respect to the subject matter hereof and supersedes all prior agreements and undertakings, both written and oral, among the parties, or any of them, with respect to the subject matter hereof. This Agreement shall not be assigned
      (whether pursuant to a merger, by operation of law or otherwise), by any party without the prior express written consent of the Company, except that a Holder may, without consent, assign such Holder’s rights under this Agreement to any transferee of
      Common Stock permitted under Sections 5.2.2 through 5.2.10 (such transferees, “Permitted Transferees”).

     

    Section 7.4. Parties in Interest. This Agreement shall be binding upon and inure solely to the
      benefit of each party hereto (and its respective permitted assigns), and nothing in this Agreement, express or implied, is intended to or shall confer upon any other person any right, benefit or remedy of any nature whatsoever under or by reason of
      this Agreement.

     

    Section 7.5. Governing Law. This Agreement shall be governed by, and construed in accordance
      with, the laws of the State of Delaware applicable to contracts executed in and to be performed in that State. All legal actions and proceedings arising out of or relating to this Agreement shall be heard and determined exclusively in any Delaware
      Chancery Court; provided, however, that if jurisdiction is not then available in the Delaware Chancery Court, then any such legal action may be brought in any federal court located in the State of Delaware or any other Delaware state
      court. The parties hereto hereby (a) irrevocably submit to the exclusive jurisdiction of the aforesaid courts for themselves and with respect to their respective properties for the purpose of any action arising out of or relating to this Agreement
      brought by any party hereto, and (b) agree not to commence any action relating thereto except in the courts described above in Delaware, other than actions in any court of competent jurisdiction to enforce any judgment, decree or award rendered by
      any such court in Delaware as described herein. Each of the parties further agrees that notice as provided herein shall constitute sufficient service of process and the parties further waive any argument that such service is insufficient. Each of the
      parties hereby irrevocably and unconditionally waives, and agrees not to assert, by way of motion or as a defense, counterclaim or otherwise, in any action arising out of or relating to this Agreement or the transactions contemplated hereby, (x) any
      claim that it is not personally subject to the jurisdiction of the courts in Delaware as described herein for any reason, (y) that it or its property is exempt or immune from jurisdiction of any such court or from any legal process commenced in such
      courts (whether through service of notice, attachment prior to judgment, attachment in aid of execution of judgment, execution of judgment or otherwise) and (z) that (i) the action in any such court is brought in an inconvenient forum, (ii) the venue
      of such action is improper or (iii) this Agreement, or the subject matter hereof, may not be enforced in or by such courts.

     

    Section 7.6. Waiver of Jury Trial. EACH OF THE PARTIES HERETO HEREBY WAIVES TO THE FULLEST EXTENT
      PERMITTED BY APPLICABLE LAW ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS AGREEMENT. EACH OF THE PARTIES HERETO (I) CERTIFIES THAT NO REPRESENTATIVE,
      AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THAT FOREGOING WAIVER AND (II) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN
      INDUCED TO ENTER INTO THIS AGREEMENT AND THE TRANSACTIONS CONTEMPLATED HEREBY, AS APPLICABLE, BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 7.6.

     

    
      17

      
        

    

     Section 7.7. Headings; Interpretation. The descriptive headings contained in this Agreement are
      included for convenience of reference only and shall not affect in any way the meaning or interpretation of this Agreement. The parties have participated jointly in the negotiation and drafting of this Agreement. If any ambiguity or question of
      intent arises, this Agreement will be construed as if drafted jointly by the parties and no presumption or burden of proof will arise favoring or disfavoring any party because of the authorship of any provision of this Agreement. Unless the context
      of this Agreement clearly requires otherwise, use of the masculine gender shall include the feminine and neutral genders and vice versa, and the definitions of terms contained in this Agreement are applicable to the singular as well as the plural
      forms of such terms. The words “includes” or “including” shall mean “including without limitation.” The words “hereof,” “hereby,” “herein,” “hereunder” and similar terms in this Agreement shall refer to this Agreement as a whole and not any
      particular section or article in which such words appear, the word “extent” in the phrase “to the extent” shall mean the degree to which a subject or other thing extends and such phrase shall not mean simply “if.” Any reference to a law shall include
      any rules and regulations promulgated thereunder, and shall mean such law as from time to time amended, modified or supplemented. References herein to any contract (including this Agreement) mean such contract as amended, supplemented or modified
      from time to time in accordance with the terms thereof.

     

    Section 7.8. Counterparts. This Agreement may be executed and delivered (including by facsimile
      or portable document format (pdf) transmission) in counterparts, and by the different parties hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the
      same agreement.

     

    Section 7.9. Specific Performance. The parties hereto agree that irreparable damage would occur
      in the event any provision of this Agreement was not performed in accordance with the terms hereof and that the parties shall be entitled to specific performance of the terms hereof, in addition to any other remedy at law or in equity. Each of the
      parties hereby further waives (a) any defense in any action for specific performance that a remedy at law would be adequate and (b) any requirement under any law to post security or a bond as a prerequisite to obtaining equitable relief.

     

    Section 7.10. Amendment. This Agreement may be amended in writing by the parties hereto at any
      time prior to the Effective Time. Following the Effective Time, this Agreement may not be amended except by an instrument in writing signed by (i) the Company, (ii) Perceptive Holders holding at least a majority in interest of the then-outstanding
      number of Registrable Securities held by all Perceptive Holders in their capacity as Perceptive Holders (provided the Perceptive Holders or their Permitted Transferees hold Registrable Securities at the time of such amendment), and (iii) New Holders
      holding at least a majority in interest of the then-outstanding number of Registrable Securities held by all New Holders in their capacity as New Holders (provided the New Holders or their Permitted Transferees hold Registrable Securities at the time
      of such amendment).

     

    Section 7.11. Waiver. At any time, (i) the Company may (a) extend the time for the performance of
      any obligation or other act of any Holder, (b) waive any inaccuracy in the representations and warranties of any Holder contained herein or in any document delivered by such Holder pursuant hereto and (c) waive compliance with any agreement of such
      Holder or any condition to its own obligations contained herein. At any time, (i) the Holders may (a) extend the time for the performance of any obligation or other act of the Company, (b) waive any inaccuracy in the representations and warranties of
      the Company contained herein or in any document delivered by the Company pursuant hereto and (c) waive compliance with any agreement of the Company or any condition to their own obligations contained herein. Any such extension or waiver shall be
      valid if set forth in an instrument in writing signed by the party or parties to be bound thereby.

     

    Section 7.12. Further Assurances. At the request of the Company, in the case of any Holder, or at
      the request of any Holder, in the case of the Company, and without further consideration, each party shall execute and deliver or cause to be executed and delivered such additional documents and instruments and take such further action as may be
      reasonably necessary to consummate the transactions contemplated by this Agreement.

     

    Section 7.13. Prior Agreement Superseded. Pursuant to Section 5.6 of the Prior Agreement, the
      undersigned parties who are parties to such Prior Agreement hereby terminate the Prior Agreement, with the intent and effect that the Prior Agreement shall hereby be replaced and superseded in its entirety by this Agreement.

     

    
      18

      
        

    

     

    Section 7.14. No Strict Construction. The language used in this Agreement shall be deemed to be
      the language chosen by the parties to express their mutual intent and no rule of strict construction shall be applied against any party.

     

    (Next Page is Signature Page)

     

    

    

    
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    IN WITNESS WHEREOF, each of the parties has executed this Agreement as of the date first written above.

     

    	 	
            COMPANY:

          
	 	 	 
	 	 	 
	 	
            By:

          	
            /s/ Chief Financial Officer

          
	 	
            Name:

          	
            Michael Altman

          
	 	
            Title:

          	
            Chief Financial Officer

          

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          	 
	 	 	 
	 	
            Name:

          	
            Perceptive Life Sciences Master Fund Ltd

          
	 	 	 
	 	
            By:

          	
            /s/ Authorized Signatory

          
	 	 	
            Name: Michael Altman

          
	 	 	
            Title: Authorized Signatory

          

    

    

     

    	 	
            Address for

          	 
	 	
            Notice:

          	
            51 Astor Pl 10th fIoor, New York, NY 10003

          
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            ARYA Sciences Holdings III

          
	 	 	 
	 	
            By:

          	
            /s/ Authorized Signatory

          
	 	 	
            Name: Michael Altman

          
	 	 	
            Title: Authorized Signatory

          

    

    

    	 	
            Address for

          	 
	 	
            Notice:

          	
            51 Astor Pl 10th fIoor, New York, NY 10003

          
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Sujal Patel

          
	 	 	 
	 	
            By:

          	
            /s/ Sujal Patel

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            PFV I, LLC

          
	 	 	 
	 	
            By:

          	
            /s/ Manager

          
	 	 	
            Name: Suraj Patel

          
	 	 	
            Title: Manager

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Sujal Patel 2020 Children’s Trust, u/a/d December 3, 2020

          
	 	 	 
	 	
            By:

          	
            /s/ Trustee

          
	 	 	
            Name: Meera Patel

          
	 	 	
            Title: Trustee

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Parag Mallick

          
	 	 	 
	 	
            By:

          	
            /s/ Parag Mallick

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Vijay Pande

          
	 	 	 
	 	
            By:

          	
            /s/ Vijay Pande

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            AH Bio Fund II, L.P.

          
	 	 	
            for itself and as nominee for

          
	 	 	
            AH Bio Fund II-B, L.P.

          
	 	 	 
	 	
            By:

          	
            AH Equity Partners Bio II, L.L.C.

          
	 	 	
            Its General Partner

          
	 	 	 
	 	
            By:

          	
            /s/ COO

          
	 	 	
            Name: Scott Kupor

          
	 	 	
            Title: COO

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	
            Name:

          	
            Andreesen Horowitz LSV Fund II, L.P.

          
	 	 	
            for itself and as nominee for

          
	 	 	
            Andreessen Horowitz LSV Fund II-B, L.P.

              and

          
	 	 	
            Andreessen Horowitz LSV Fund II-Q, L.P.

          
	 	 	 
	 	
            By:

          	
            AH Equity Partners LSV II, L.L.C.

          
	 	 	
            General Partner

          
	 	 	 
	 	
            By:

          	
            /s/ Chief Operating Officer

          
	 	 	
            Name: Scott Kupor

          
	 	 	
            Title: Chief Operating Officer

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Farzad Nazem

          
	 	 	 
	 	
            By:

          	
            /s/ Farzad Nazem

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            HAND Capital, LLC

          
	 	 	 
	 	
            By:

          	
            /s/ Manager

          
	 	 	
            Name: Farzad Nazem

          
	 	 	
            Title: Manager

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Matthew McIlwain

          
	 	 	 
	 	
            By:

          	
            /s/ Matthew McIlwain

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Madrona Venture Fund VI, LP

          
	 	 	 
	 	
            By:

          	
            Madrona Investment Partners, VI, LP,

          
	 	 	
            its General Partner

          
	 	
            By:

          	
            Madrona VI General Partner, LLC,

          
	 	 	
            its General Partner

          
	 	 	 
	 	
            By:

          	
            /s/ Authorized Signatory

          
	 	 	
            Name: Troy Cichos

          
	 	 	
            Title: Authorized Signatory

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Madrona Venture Fund VI-A, LP

          
	 	 	 
	 	
            By:

          	
            Madrona Investment Partners, VI, LP,

          
	 	 	
            its General Partner

          
	 	 	 
	 	
            By:

          	
            Madrona VI General Partner, LLC,

          
	 	 	
            its General Partner

          
	 	 	 
	 	
            By:

          	
            /s/ Authorized Signatory

          
	 	 	
            Name: Troy Cichos

          
	 	 	
            Title: Authorized Signatory

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          	 
	 	 	 
	 	
            Name:

          	
            VCVC V LLC

          
	 	 	 
	 	
            By:

          	
            VCVC Management V LLC, Its Manager

          
	 	
            By:

          	
            Cougar Investment Holdings LLC,

          
	 	 	
            Its Managing Member

          
	 	 	 
	 	
            By:

          	
            /s/ Vice President

          
	 	 	
            Name: Danielle Harper

          
	 	 	
            Title: Vice President

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

     

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    

    

     

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          	 
	 	 	 
	 	
            Name:

          	
            Vulcan Capital Columbia Holdings LLC

          
	 	 	 
	 	
            By:

          	
            VCVC Management V LLC, Its Manager

          
	 	
            By:

          	
            Cougar Investment Holdings LLC,

          
	 	 	
            Its Manager

          
	 	 	 
	 	
            By:

          	
            /s/ Vice President

          
	 	 	
            Name: Danielle Harper

          
	 	 	
            Title: Vice President

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

     

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Melissa Epperly

          
	 	 	 
	 	
            By:

          	
            /s/ Melissa Epperly

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Matthew Posard

          
	 	 	 
	 	
            By:

          	
            /s/ Matthew Posard

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Todd Wider

          
	 	 	 
	 	
            By:

          	
            /s/ Todd Wider

          
	 	 	
            Name: Todd Wider

          
	 	 	
            Title:

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Bradley L. Campbell

          
	 	 	 
	 	
            By:

          	
            /s/ Bradley L. Campbell

          
	 	 	
            Name: Bradley L. Campbell

          
	 	 	
            Title:

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    IN WITNESS WHEREOF, each of the undersigned has executed this Agreement as of the date first written above.

     

    	 	
            HOLDER:

          
	 	 	 
	 	
            Name:

          	
            Saqib Islam

          
	 	 	 
	 	
            By:

          	
            /s/ Saqib Islam

          
	 	 	
            Name: Saqib Islam

          
	 	 	
            Title:

          
	 	 	 
	 	
            Address for

          	 
	 	
            Notice:

          	 
	 	 	 
	 	
            Telephone No.:

          	 
	 	 	 
	 	
            Facsimile No.:

          	 
	 	 	 
	 	
            Email

          	 
	 	
            Address:

          	 

    

    

    

    

    [Signature Page to Amended and Restated Registration Rights and Lock-Up Agreement]

    

    

    

    

    
      
        

    

    Schedule A

     

    	
            Perceptive Holders

              

            

          
	
            Name of Holder

          
	
            Perceptive Life Sciences Master Fund Ltd.

          
	
            ARYA Sciences Holdings III

          
	
             

            

            New Holders

             

            

          
	
            Name of Holder

          
	
            Sujal Patel

          
	
            PFV I, LLC

          
	
            Sujal Patel 2020 Children’s Trust, u/a/d December 3, 2020

          
	
            Parag Mallick

          
	
            Vijay Pande

          
	
            AH Bio Fund II, L.P.

          
	
            Andreesen Horowitz

          
	
            LSV Fund II, L.P.

          
	
            Farzad Nazem

          
	
            HAND Capital, LLC

          
	
            Matthew McIlwain

          
	
            Madrona Venture Fund VI, LP

          
	
            Madrona Venture Fund VI-A, LP

          
	
            VCVC V LLC

          
	
            Vulcan Capital Columbia Holdings LLC

          
	
            Melissa Epperly

          
	
            Matthew Posard

          
	
             

            

            Independent Directors

             

            

          
	
            Name of Holder

          
	
            Todd Wider

          
	
            Bradley L. Campbell

          
	
            Saqib Islam

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00320-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00320-of-00352.parquet"}]]