Document:

<PAGE>

                                                                   EXHIBIT 10.23

                           LOAN AND SECURITY AGREEMENT

BORROWER: ATHENAHEALTH, INC., A DELAWARE CORPORATION

ADDRESS:  311 ARSENAL STREET
          WATERTOWN, MASSACHUSETTS 02472

DATE:     MARCH 31, 2006

This Loan and Security Agreement is entered into on the above date between Bank
of America, N.A. ("Lender") and the borrower named above ("Borrower"), whose
chief executive office is located at the above address ("Borrower's Address").
The Schedule to this Loan and Security Agreement being signed concurrently (the
"Schedule") is an integral part of this Agreement. (Definitions of certain terms
used in this Agreement are set forth in Section 7 below).

WHEREAS, the Borrower and ORIX Venture Finance LLC ("ORIX") are parties to that
certain Loan and Security Agreement, dated as of December 28, 2005 (the "ORIX
Credit Agreement"), whereby ORIX made certain equipment loans (the "Equipment
Loans") to the Borrower;

WHEREAS, the outstanding principal amount of the Equipment Loans under the ORIX
Credit Agreement as of the date hereof is $2,741,505.03;

WHEREAS, pursuant to that certain Assignment and Assumption, dated as of the
date hereof, ORIX assigned the Equipment Loans, together with all rights and
obligations under the ORIX Credit Agreement and related loan documents with
respect to the Equipment Loans, including, without limitation, all liens granted
by the Borrower to ORIX in the Collateral (as defined below) and proceeds
thereof (collectively, the "Assigned Interests"); and

WHEREAS, the parties hereto wish to document the Assigned Interests as set forth
herein.

NOW THEREFORE, in consideration of the mutual covenants and agreements herein
contained, the parties hereto covenant and agree effective as of the date
hereof, as follows:

1. LOANS.

     1.1 EQUIPMENT LOAN. As of the date hereof, there are $2,741,505.03 of
Equipment Loans outstanding (each, a "Loan" and collectively, the "Loans"). The
Lender shall have no obligation to make any further Loans to the Borrower under
this Agreement. The Equipment Loans shall be evidenced by a Promissory Note made
by Borrower to Lender, on Lender's standard form (the "Note") and shall be
repayable as therein set forth, provided that the entire unpaid principal
balance of the Loans and any accrued and unpaid interest thereon shall be due
and payable on the Maturity Date set forth in the Schedule. Once repaid, the
Loans may not be reborrowed.

     1.2 CONDITIONS. The effectiveness of this Agreement is subject to the
satisfaction of the following conditions precedent: (i) all filings have been
completed that are necessary or advisable to perfect the security interest of
Lender in the Collateral, (ii) all documents relating to this Agreement have
been executed and delivered, (iii) Lender has confirmed to its satisfaction that
there has been no Material Adverse Change since the date of the last financial
statements provided to Lender, (iv) UCC and other searches deemed necessary by
Lender have been completed and the results thereof are satisfactory to Lender,
(v) Lender shall have received satisfactory evidence that all security interests
of ORIX and Silicon Valley Bank in the Collateral shall have been terminated,
(vi) Lender shall have received a fully executed assignment and assumption
agreement among Borrower, ORIX and Lender, (vii) Lender shall have received an
insurance certificate, naming Lender as loss payee with respect to the
Collateral, (viii) Lender shall have received (i) a certificate as to the good
standing of Borrower from the Secretary of State of Delaware and (ii) a
certificate of an authorized officer of Borrower certifying and attaching

                                       -1-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

copies of its governing documents and resolutions authorizing the transactions
contemplated under this Agreement, and (ix) all other matters relating to the
Loans have been completed to Lender's reasonable satisfaction.

     1.3 INTEREST. The Loans and all other monetary Obligations shall bear
interest at the rate shown on the Schedule, except where expressly set forth to
the contrary in this Agreement or in another written agreement signed by Lender
and Borrower. Borrower shall pay interest on the Loans accrued for each month no
later than the fifth day of the following month, and at maturity.

     1.4 [INTENTIONALLY OMITTED].

     1.5 PLACE AND MANNER. Borrower shall make all payments due to Lender in
lawful money of the United States. All payments of principal, interest, fees and
other amounts payable by Borrower hereunder shall be made, in immediately
available funds, by wire transfer to Lender not later than 1:00 p.m. New York
time, on the date on which such payment is due,

     1.6 LATE FEE. If any payment of principal, interest or any other payment is
not made within five Business Days after the date due, Borrower shall pay a late
payment fee equal to 5% of the amount of such late payment. In addition, if the
entire balance of the Loans and all other monetary Obligations are not paid in
full by the Maturity Date set forth on the Schedule, Borrower shall pay Lender a
late charge of $50,000. The provisions of this paragraph shall not be construed
as Lender's consent to Borrower's failure to pay any amounts when due, and
Lender's acceptance of any such late payments shall not restrict Lender's
exercise of any remedies arising out of any such failure.

2. SECURITY INTEREST.

     2.1 SECURITY INTEREST. To secure the payment and performance of all of the
Obligations when due, Borrower hereby grants to Lender a security interest in
all of the following (collectively, the "Collateral"): all right, title and
interest of Borrower in and to the following, whether now owned or hereafter
arising or acquired and wherever located: all Equipment listed on Schedule 2.1
hereto; and any and all claims, rights and interests in any of the above, and
all guaranties and security for any of the above, and all substitutions and
replacements for, additions, accessions, attachments, accessories, and
improvements to, and proceeds (including proceeds of any insurance policies,
proceeds of proceeds and claims against third parties) of, any and all of the
above, and all Borrower's books relating to any of the above. Borrower hereby
irrevocably authorizes Lender at any time and from time to time to file in any
filing office in any Uniform Commercial Code jurisdiction any initial financing
statements and amendments thereto that (a) indicate the Collateral and (b)
provide any other information required by part 5 of Article 9 of the Uniform
Commercial Code of the applicable state or such other jurisdiction for the
sufficiency or filing office acceptance of any financing statement or amendment,
including whether Borrower is an organization, the type of organization and any
organizational identification number issued to Borrower. Borrower agrees to
furnish any such information to the Lender promptly upon request. Borrower also
ratifies its authorization for Lender to have filed in any Uniform Commercial
Code jurisdiction any like initial financing statements or amendments thereto if
filed prior to the date hereof.

3. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE BORROWER.

     In order to induce Lender to enter into this Agreement, Borrower represents
and warrants to Lender as follows, and Borrower covenants that the following
representations will continue to be true, and that Borrower will at all times
comply with all of the following covenants:

     3.1 CORPORATE EXISTENCE AND AUTHORITY. Borrower is and will continue to be,
duly organized, validly existing and in good standing under the laws of the
State of DELAWARE. Borrower is and will continue to be qualified and licensed to
do business in all jurisdictions in which any failure to do so would result in a
Material Adverse Change. The execution, delivery and performance by Borrower of
this Agreement, and all other documents contemplated hereby (i) have been duly
and validly authorized, (ii) are enforceable against Borrower in accordance with
their terms (except as enforcement may be limited by equitable principles and by
bankruptcy, insolvency, reorganization, moratorium or similar laws relating to
creditors' rights generally), (iii) do not violate Borrower's articles or
certificate of incorporation, or Borrower's by-laws, or any law or any material
agreement or instrument which is binding upon Borrower or its property, and (iv)
do not constitute grounds for acceleration of any indebtedness or obligation
under any agreement or instrument which is binding upon Borrower or its
property.

     3.2 NAME; TRADE NAMES AND STYLES. The full correct name of Borrower and its
state of incorporation are set forth in this Agreement. Listed on the
Representations, are all prior names of Borrower and all of Borrower's present
and prior trade names. Borrower shall give Lender 30 days' prior written notice
before changing its name or doing business under any other name. Borrower has
complied, and will in the future comply, with all laws relating to the conduct
of business under a fictitious business name.

     3.3 PLACE OF BUSINESS; LOCATION OF COLLATERAL. The address set forth in the
heading to this Agreement is Borrower's chief executive office. In addition,
Borrower has places of business and Collateral is located only at the locations
set forth in the Representations. Borrower will give Lender at least 15 days
prior written notice before opening any additional place of business, changing
its chief executive office or state of incorporation, or moving

                                       -2-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

any of the Collateral to a location other than Borrower's Address or one of the
locations set forth on the Schedule.

     3.4 TITLE TO COLLATERAL. Borrower is now, and will at all times in the
future be, the sole owner of all the Collateral. The Collateral now is and will
remain free and clear of any and all liens, charges, security interests,
encumbrances and adverse claims, except for the security interest in favor of
Lender. Lender now has, and will continue to have, a first-priority perfected
and enforceable security interest in all of the Collateral and Borrower will at
all times defend Lender and the Collateral against all claims of others. None of
the Collateral now is or will be affixed to any real property in such a manner,
or with such intent, as to become a fixture. Borrower will keep in full force
and effect, and will comply, in all material respects, with all the terms of,
any lease of real property where any of the Collateral now or in the future may
be located.

     3.5 MAINTENANCE OF COLLATERAL. Borrower, at its expense, shall maintain the
Collateral in good working condition, ordinary wear and tear excepted, and
Borrower will not use the Collateral for any unlawful purpose. Borrower will
immediately advise Lender in writing of any material loss or damage to the
Collateral.

     3.6 BOOKS AND RECORDS. Borrower has maintained and will maintain at
Borrower's Address complete and accurate books and records, comprising an
accounting system in accordance with GAAP.

     3.7 FINANCIAL CONDITION, STATEMENTS AND REPORTS. All financial statements
now or in the future delivered to Lender have been, and will be, prepared in
conformity with GAAP and now and in the future will completely and fairly
reflect, in all material respects, the financial condition of Borrower, at the
times and for the periods therein stated. Between the last date covered by any
such statement provided to Lender and the date hereof, there has been no
Material Adverse Change. Borrower is now and will continue to be able to pay its
debts (including trade debts) as they become due, and the sum of the Borrower's
assets does now, and will continue to exceed the amount of its debts, as
calculated under GAAP.

     3.8 TAX RETURNS AND PAYMENTS; PENSION CONTRIBUTIONS. Except as set forth on
the Disclosure Schedule attached hereto as Exhibit A (the "Disclosure
Schedule"), Borrower has timely filed, and will timely file, all tax returns and
reports required by applicable law, and Borrower has timely paid, and will
timely pay, all applicable taxes, assessments, deposits and contributions now or
in the future owed by Borrower, except those being contested in good faith by
appropriate proceedings diligently pursued, with adequate reserves maintained in
accordance with GAAP, and as to which no lien exists which would have priority
over the security interest of Lender.

     3.9 COMPLIANCE WITH LAW. Borrower has complied, and will comply, in all
material respects, with all provisions of all applicable laws and regulations,
including, but not limited to, those relating to Borrower's ownership of real or
personal property, the conduct and licensing of Borrower's business,
compensation and benefits payable or provided to Borrower's employees, and all
environmental matters. All proceeds of all Loans shall be used solely for lawful
business purposes.

     3.10 LITIGATION. Except as set forth in the Disclosure Schedule, there is
no claim asserted in writing, suit, litigation, proceeding or governmental
investigation pending or threatened against or affecting Borrower involving more
than $25,000. Borrower will promptly inform Lender in writing of any claim
asserted in writing, proceeding, litigation or governmental investigation in the
future threatened or instituted by or against Borrower involving any claim of
$100,000 or more

4. ADDITIONAL DUTIES OF THE BORROWER.

     4.1 INSURANCE. Borrower shall, at all times, insure all of the Collateral
and carry such other business insurance, with insurers reasonably acceptable to
Lender, in such form and amounts as Lender may reasonably require, and Borrower
shall provide evidence of such insurance to Lender, so that Lender is satisfied
that such insurance is, at all times, in full force and effect. All such
casualty insurance policies shall name Lender as an additional loss payee, and
shall contain a lenders loss payee endorsement in form reasonably acceptable to
Lender. Upon receipt of the proceeds of any insurance relating to Collateral,
Lender shall apply the proceeds to the Obligations, except that, provided no
Default or Event of Default has occurred and is continuing, Lender shall release
to Borrower insurance proceeds with respect to the Collateral, which shall be
utilized by Borrower for the replacement of the Collateral with respect to which
the insurance proceeds were paid. Lender may require reasonable assurance that
the insurance proceeds so released will be so used, which may, in Lender's good
faith business judgment, include an escrow account into which insurance proceeds
will be deposited and from which replacement Collateral will be purchased. If
Borrower fails to provide or pay for any such requested insurance, Lender may,
but is not obligated to, obtain the same at Borrower's expense. Borrower shall
promptly deliver to Lender copies of all reports made to insurance companies.

     4.2 REPORTS. Borrower, at its expense, shall provide Lender with the
written reports set forth in the Schedule, and such other written reports with
respect to Borrower (including budgets, sales projections, operating plans and
other financial documentation), as Lender shall from time to time reasonably
specify.

     4.3 ACCESS TO COLLATERAL, BOOKS AND RECORDS. At reasonable times (no more
than once during any 12-month period), and on three Business Day's notice
(except if a Default or Event of Default has occurred and is continuing or if
Lender in its good faith business judgment believes or suspects that Borrower
has engaged in defalcation,

                                       -3-
<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

intentional misrepresentation, or fraud, in which case then Lender may do the
following at any time, without any notice and without subject to the foregoing
limit on number of inspections), Lender shall have the right to inspect the
Collateral, and the right to audit and copy Borrower's books and records and, in
such inspections and audits may be accompanied by representatives of Lender. The
foregoing inspections and audits shall be at Borrower's expense and the charge
therefor shall be at Lender's then standard charge for the same, plus all other
reasonable out-of-pockets costs and expenses incurred by Lender in connection
therewith.

     4.4 REMITTANCE OF PROCEEDS. All proceeds arising from the sale or other
disposition of any Collateral shall be delivered, in kind, by Borrower to
Lender, in the original form in which received by Borrower not later than the
following Business Day after receipt by Borrower, to be applied to the
Obligations in such order as Lender shall determine. Nothing in this Section
limits the restrictions on disposition of Collateral set forth elsewhere in this
Agreement.

     4.5 NEGATIVE COVENANTS. Borrower shall not, without Lender's prior written
consent, do any of the following: (i) merge or consolidate with another
corporation or entity; (ii) acquire any assets, except in the ordinary course of
business in excess of $250,000 in any fiscal year; (iii) enter into any other
transaction outside the ordinary course of business; (iv) sell or transfer any
Collateral; (v) store any Collateral with any warehouseman or other third party,
without an agreement reasonably acceptable to Lender that any rights of any such
warehouseman or other third party are subject to Lender's rights therein;
provided that, as to servers owned by Borrower and maintained with Savvis
Communications Corporation, such agreement may be provided within 30 days after
the date of this Agreement, (vi) make any loans of any money or other assets to,
or purchase the stock or other securities of, or make any other investment in,
any other Person, other than in accordance with Borrower's recommended
investment policy guidelines adopted January 2001, or in excess of an aggregate
of $200,000 outstanding at any time; (vii) guarantee or otherwise become liable
with respect to the obligations of another Person; (viii) pay or declare any
dividends on Borrower's stock (other than dividends payable solely in shares of
stock of Borrower); (ix) redeem, retire, purchase or otherwise acquire, directly
or indirectly, any of Borrower's stock, except for the following in an amount
not in excess of $250,000 in the aggregate in any fiscal year: pursuant to
agreements with employees or as provided for in Borrower's equity compensation
plans or any agreement issued pursuant thereto; (x) make any change in
Borrower's organizational structure; (xi) reincorporate in another state; or
(xii) dissolve or elect to dissolve; or (xiii) agree to do any of the foregoing.

     4.6 LITIGATION COOPERATION. Should any third-party suit or proceeding be
instituted by or against Lender with respect to any Collateral or in any manner
relating to Borrower, Borrower shall, without expense to Lender, make available
Borrower and its officers, employees and agents, and Borrower's books and
records, without charge, to the extent that Lender may deem them reasonably
necessary in order to prosecute or defend any such suit or proceeding.

     4.7 NOTIFICATION OF CHANGES. Borrower will promptly notify Lender in
writing of any change in its executive officers or directors and any Material
Adverse Change.

     4.8 [INTENTIONALLY OMITTED].

     4.9 LANDLORD AGREEMENTS. Borrower shall, from time to time, upon Lender's
request, use its best efforts to obtain written waivers and agreements from
Borrower's landlords, on such form and containing such provisions as Lender
shall specify.

     4.10 [INTENTIONALLY OMITTED].

     4.11 FURTHER ASSURANCES. Borrower agrees, at its expense, on request by
Lender, to execute all documents and take all actions, as Lender may reasonably
deem necessary or useful in order to perfect and maintain the perfected security
interest in the Collateral of Lender, and in order to fully consummate the
transactions contemplated by this Agreement.

     4.12 INDEMNITY. Borrower hereby agrees to indemnify the following Persons
(collectively, the "Indemnitees"): Lender and its affiliates, subsidiaries,
parent, directors, officers, employees, agents, and attorneys, and to hold them
harmless from and against any and all claims, debts, liabilities, demands,
obligations, actions, causes of action, penalties, costs and expenses (including
reasonable attorneys' fees and expenses), of every nature, character and
description, which any Indemnitee may sustain or incur based upon or arising out
of any of the Obligations, any relationship or agreement between Lender, on the
one hand, and Borrower, on the other hand, or any other matter, cause or thing
whatsoever occurred, done, omitted or suffered to be done by any Indemnitee
relating to Borrower and the transactions contemplated by this Agreement or any
other Loan Document, or the Obligations, or the relationship between Lender and
Borrower (collectively "Indemnifiable Losses"); provided that the indemnity
hereunder to an Indemnitee shall not extend to (i) damages proximately caused by
such Indemnitee's own gross negligence or willful misconduct, or (ii) any
Indemnifiable Losses based upon, or arising out of, any dispute solely among
Indemnitees. Notwithstanding any provision in this Agreement to the contrary,
the indemnity agreement set forth in this Section shall survive any termination
of this Agreement and shall for all purposes continue in full force and effect.

5. TERM.

     5.1 MATURITY DATE. Borrower shall pay and perform in full all outstanding
Obligations, whether evidenced by

                                       -4-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

installment notes or otherwise, and whether or not all or any part of such
Obligations are otherwise then due and payable, on the maturity date set forth
on the Schedule (the "Maturity Date") or any earlier occurrence of (i) any Event
of Default as to which Lender has given written notice to Borrower that it has
accelerated and declared the Obligations to be immediately due and payable, or
(ii) any Event of Default consisting of (A) the commencement of any proceeding
by Borrower under any reorganization, bankruptcy, insolvency, arrangement,
readjustment of debt, dissolution or liquidation law or statute of any
jurisdiction, now or in the future in effect (collectively, an "Insolvency
Proceeding"), or (B) the commencement of any Insolvency Proceeding against
Borrower which is not dismissed or stayed within 60 days after the date
commenced.

     5.2 PREPAYMENT.

     (a) [INTENTIONALLY OMITTED].

     (b) Borrower shall have the option of prepaying the principal amount of any
Loan, prior to the dates set forth in Section 1(a) of the Schedule, in whole or
in part, provided that Borrower concurrently pays Lender (i) all accrued and
unpaid interest on the principal so prepaid and (ii) a prepayment fee equal to
3% of the amount prepaid if prepayment occurs on or before February 28, 2007 and
1% of the amount prepaid if prepayment occurs after February 28, 2007. Said
prepayment fee shall be due from Borrower to Lender upon any prepayment of the
principal of any Loan, including without limitation any prepayment as a result
of an Event of Default or the exercise of any rights or remedies by Lender
following the same.

     5.3 TERMINATION STATEMENTS. Upon payment and performance in full of all the
Obligations and termination of this Agreement, Lender shall promptly deliver to
Borrower UCC termination statements and such other documents as may be
reasonably required to terminate Lender's security interests in the Collateral.

6. EVENTS OF DEFAULT AND REMEDIES.

     6.1 EVENTS OF DEFAULT. The occurrence of any of the following events shall
constitute an "Event of Default" under this Agreement, and Borrower shall give
Lender immediate written notice thereof:

     (a) Any warranty, representation, statement, report or certificate when
made or delivered to Lender by Borrower or any of Borrower's officers, employees
or agents, now or in the future, shall be untrue or misleading in a material
respect; or

     (b-1) Borrower shall fail to pay any principal or interest payment on any
Loan, within three Business Days after the date due, or

     (b-2) Borrower shall fail to pay any other monetary Obligation within five
Business Days after the date due, or

     (c) written notice of any Event of Default shall have been given by (i)
ORIX under the ORIX Credit Agreement or (ii) SVB under the SVB Loan Agreement;
or

     (d) Borrower shall fail to comply with any provision under Subsection 4.5
hereof; or

     (e-1) Borrower shall fail to provide the financial reports called for by
Section 5 of the Schedule which is not cured within three Business Days after
the date due; or

     (e-2) Borrower shall fail to perform any other nonmonetary Obligation which
is not cured within three Business Days after the date written notice of such
failure is given to Borrower (provided that after a total of three such written
notices have been given for any and all failures to perform non-monetary
Obligations, no further such written notice shall be required, and thereafter a
failure to perform a non-monetary Obligation which is not cured within three
Business Days after the date performance was due shall constitute an Event of
Default); or

     (f) any levy, assessment, attachment, seizure, lien or encumbrance is made
on all or any part of the Collateral which is not cured within 10 days after the
occurrence of the same; or

     (g) if there is a default in any agreement to which Borrower is a party
with a third party or parties resulting in a right by such third party or
parties, whether or not exercised, to accelerate the maturity of any
indebtedness of Borrower in an amount in excess of $100,000 or that could result
in a Material Adverse Change; or

     (h) dissolution, termination of existence, insolvency, business failure or
temporary or permanent suspension of business of Borrower; or appointment of a
receiver, trustee or custodian, for all or any part of the property of,
assignment for the benefit of creditors by, or the commencement of any
Insolvency Proceeding against Borrower which is not dismissed or stayed within
60 days after the date commenced, or the commencement of any Insolvency
Proceeding by Borrower; or

     (i) revocation or termination of, or limitation or denial of liability
upon, any guaranty of the Obligations or any attempt to do any of the foregoing;
or

     (j) revocation or termination of, or limitation or denial of liability
upon, any pledge of any certificate of deposit, securities, money or other
property or asset pledged by any third party to secure any or all of the
Obligations, or any attempt to do any of the foregoing, or commencement of
proceedings by or against any such third party under any bankruptcy or
insolvency law; or

     (k) there shall be a change in the record or beneficial ownership of an
aggregate of more than 30% of the outstanding shares of stock or other equity
ownership interest in Borrower, in one or more transactions, compared to the
ownership of outstanding shares of stock

                                       -5-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

of Borrower in effect on the date hereof, without the prior written consent of
Lender, except for (i) changes resulting from, or occurring after, an initial
public offering of Borrower's common stock in which at least $25,000,000 is
raised, and (ii) changes resulting from distributions of stock of the Borrower
by stockholders of Borrower to their shareholders (in the case of stockholders
of Borrower which are corporations) or to their members (in the case of
stockholders of Borrower which are limited liability companies) or to their
partners (in the case of stockholders of Borrower which are partnerships); or

     (l) Borrower shall generally not pay its debts as they become due, or
Borrower shall conceal, remove or transfer any part of its property, with intent
to hinder, delay or defraud its creditors, or make or suffer any transfer of any
of its property which may be fraudulent under any bankruptcy, fraudulent
conveyance or similar law; or

     (m) a Material Adverse Change shall occur; or

     (n) Borrower makes any payment on account of any indebtedness or obligation
which has been subordinated to the Obligations other than as permitted in the
applicable subordination agreement, or if any Person who has subordinated such
indebtedness or obligations terminates or in any way limits his subordination
agreement; or

     (o) an event of default shall occur and be continuing under any other Loan
Document (after giving effect to, but without duplication of, grace periods
under such other Loan Document applicable thereto).

     6.2 REMEDIES. Upon the occurrence and during the continuance of any Event
of Default, Lender, at its option, and without notice or demand of any kind (all
of which are hereby expressly waived by Borrower), may do any one or more of the
following: (a) Accelerate and declare all or any part of the Obligations to be
immediately due, payable, and performable, notwithstanding any deferred or
installment payments allowed by any instrument evidencing or relating to any
Obligation (provided that upon the commencement of any proceeding by or against
Borrower under any reorganization, bankruptcy, insolvency, arrangement,
readjustment of debt, dissolution or liquidation law or statute of any
jurisdiction, now or in the future in effect the Obligations shall automatically
become immediately due and payable); (b) Accelerate or extend the time of
payment of, compromise, issue credits on, or bring suit on the Collateral (in
the name of Borrower or Lender) and otherwise administer and collect the
Collateral; (c) Take possession of any or all of the Collateral wherever it may
be found, and for that purpose Borrower hereby authorizes Lender without
judicial process to enter onto any of Borrower's premises without interference
to search for, take possession of, keep, store, or remove any of the Collateral,
and remain on the premises or cause a custodian to remain on the premises in
exclusive control thereof, without charge for so long as Lender deems it
reasonably necessary in order to complete the enforcement of its rights under
this Agreement or any other agreement; provided, however, that should Lender
seek to take possession of any of the Collateral by court process, Borrower
hereby irrevocably waives: (i) any bond and any surety or security relating
thereto required by any statute, court rule or otherwise as an incident to such
possession; (ii) any demand for possession prior to the commencement of any suit
or action to recover possession thereof; and (iii) any requirement that Lender
retain possession of, and not dispose of, any such Collateral until after trial
or final judgment; (d) Require Borrower to assemble any or all of the Collateral
and make it available to Lender at places designated by Lender which are
reasonably convenient to Lender and Borrower, and to remove the Collateral to
such locations as Lender may deem advisable; (e) Complete the processing,
manufacturing or repair of any Collateral prior to a disposition thereof and,
for such purpose and for the purpose of removal, Lender shall have the right to
use Borrower's premises, vehicles, hoists, lifts, cranes, equipment and all
other property without charge; (f) Sell, lease or otherwise dispose of any of
the Collateral, in its condition at the time Lender obtains possession of it or
after further manufacturing, processing or repair, at one or more public and/or
private sales, in lots or in bulk, for cash, exchange or other property, or on
credit, and to adjourn any such sale from time to time without notice other than
oral announcement at the time scheduled for sale. Lender shall have the right to
conduct such disposition on Borrower's premises without charge, for such time or
times as Lender deems reasonable, or on a Lender's premises, or elsewhere and
the Collateral need not be located at the place of disposition. Lender may
directly or through any affiliated company purchase or lease any Collateral at
any such public disposition, and if permissible under applicable law, at any
private disposition. Any sale or other disposition of Collateral shall not
relieve Borrower of any liability Borrower may have if any Collateral is
defective as to title or physical condition or otherwise at the time of sale.
All reasonable attorneys' fees, expenses, costs, liabilities and obligations
incurred by Lender with respect to the foregoing shall be added to and become
part of the Obligations, shall be due on demand, and shall bear interest at a
rate equal to the highest interest rate applicable to any of the Obligations.
Without limiting any of Lender's rights and remedies, and regardless of the
adequacy of any Collateral securing the Obligations, Lender may exercise a right
of offset with respect to any and all indebtedness, liabilities and obligations
owing from it to Borrower, to the full extent of all of the Obligations owing to
Lender. Without limiting any of Lender's rights and remedies, from and after the
occurrence, and during the continuance, of any Event of Default, the interest
rate applicable to the Obligations shall be increased by an additional two
percent per annum.

     6.3 STANDARDS FOR DETERMINING COMMERCIAL REASONABLENESS. Borrower and
Lender agree that a sale or other disposition (collectively, "sale") of any
Collateral

                                       -6-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

which complies with the following standards will conclusively be deemed to be
commercially reasonable: (i) Notice of the sale is given to Borrower at least
seven days prior to the sale, and, in the case of a public sale, notice of the
sale is published at least seven days before the sale in a newspaper of general
circulation in the county where the sale is to be conducted; (ii) Notice of the
sale describes the collateral in general, non-specific terms; (iii) The sale is
conducted at a place designated by Lender, with or without the Collateral being
present; (iv) The sale commences at any time between 8:00 a.m. and 6:00 p.m.;
(v) Payment of the purchase price in cash or by cashier's check or wire transfer
is required; (vi) With respect to any sale of any of the Collateral, Lender may
(but is not obligated to) direct any prospective purchaser to ascertain directly
from Borrower any and all information concerning the same. Lender shall be free
to employ other methods of noticing and selling the Collateral, in its
discretion, if they are commercially reasonable.

     6.4 [INTENTIONALLY OMITTED].

     6.5 POWER OF ATTORNEY. Borrower grants to Lender an irrevocable power of
attorney coupled with an interest, authorizing and permitting Lender (acting
alone, through any of its employees, attorneys or agents) at any time, until the
Obligations have been paid and performed in full, at its option, but without
obligation, with or without notice to Borrower, and at Borrower's expense, to do
any or all of the following, in Borrower's name or otherwise, but Lender agrees
to exercise the following powers in a commercially reasonable manner: (a)
Execute on behalf of Borrower any documents that Lender may, in its good faith
business judgment, deem advisable in order to perfect and maintain its security
interest in the Collateral, or in order to exercise a right of Lender or
Borrower, or in order to fully consummate all the transactions contemplated
under this Agreement, or under any and all other present and future agreements,
to make any payment or take any action necessary or desirable to protect or
preserve any Collateral or Lender's security interest therein or the priority
thereof, or in order to fully consummate all the transactions contemplated under
this Agreement or any other Loan Document; (b) After the occurrence and during
the continuance of any Event of Default, without limiting Lender's other rights
and remedies, do any of the following: (i) Take control in any manner of any
cash or non-cash items of payment or proceeds of Collateral; endorse the name of
Borrower upon any instruments, or documents, evidence of payment or Collateral
that may come into Lender's possession; (ii) Pay any sums required on account of
Borrower's taxes or to secure the release of any liens therefor; and (iii)
Settle and adjust, and give releases of, any insurance claim that relates to any
of the Collateral and obtain payment therefor.

     6.6 APPLICATION OF PROCEEDS. All proceeds realized as the result of any
sale or other disposition of the Collateral shall be applied by Lender first to
the reasonable costs, expenses, liabilities, obligations and attorneys' fees
incurred by Lender in the exercise of its rights under this Agreement, second to
the interest due upon any of the Obligations, and third to the principal of the
Obligations. Any surplus shall be paid to Borrower or other Persons legally
entitled thereto; Borrower shall remain liable to Lender for any deficiency. If
Lender, in its sole discretion, directly or indirectly enters into a deferred
payment or other credit transaction with any purchaser at any sale of
Collateral, Lender shall have the option, exercisable at any time, in its sole
discretion, of either reducing the Obligations by the principal amount of
purchase price or deferring the reduction of the Obligations until the actual
receipt by Lender of the cash therefor.

     6.7 REMEDIES CUMULATIVE. In addition to the rights and remedies set forth
in this Agreement, Lender shall have all the other rights and remedies accorded
a secured party under the Code and under all other applicable laws, and under
any other instrument or agreement now or in the future entered into between
Lender and Borrower, and all of such rights and remedies are cumulative and none
is exclusive. Exercise or partial exercise by Lender of one or more of its
rights or remedies shall not be deemed an election, nor bar Lender from
subsequent exercise or partial exercise of any other rights or remedies. The
failure or delay of Lender to exercise any rights or remedies shall not operate
as a waiver thereof, but all rights and remedies shall continue in full force
and effect until all of the Obligations have been fully paid and performed.

7. DEFINITIONS. As used in this Agreement, the following terms have the
following meanings:

     "Agreement" and "this Agreement" means this Loan and Security Agreement and
all Exhibits and Schedules hereto and all modifications and amendments to,
extensions of, and replacements for this Agreement.

     "Base Rate" means for any day a fluctuating rate per annum equal to the
higher of (a) the Federal Funds Rate plus 1/2 of 1% and (b) the rate of interest
in effect for such day as publicly announced from time to time by Lender as its
"prime rate." The "prime rate" is a rate set by Lender based upon various
factors including Lender's costs and desired return, general economic conditions
and other factors, and is used as a reference point for pricing some loans,
which may be priced at, above, or below such announced rate. Any change in such
rate announced by Lender shall take effect at the opening of business on the day
specified in the public announcement of such change.

     "Business Day" means any day other than a Saturday, Sunday or any other day
on which commercial banks in Boston, Massachusetts are required or permitted by
law to close.

                                       -7-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

     "Code" means the Uniform Commercial Code as adopted and in effect in the
Commonwealth of Massachusetts on the date hereof.

     "Collateral" has the meaning set forth in Section 2.1 above.

     "continuing" when used with reference to a Default or an Event of Default
means that the Default or Event of Default has occurred and has not been either
waived in writing by Lender or cured within any applicable cure period.

     "Default" means any event which with notice or passage of time or both,
would constitute an Event of Default.

     "Equipment" means all of the following, now owned and hereafter acquired by
Borrower: all "equipment" as defined in the Code in effect on the date hereof
with such additions to such term as may hereafter be made, and includes without
limitation all machinery, fixtures, goods, vehicles, and any interest in any of
the foregoing.

     "Event of Default" means any of the events set forth in Section 6.1 of this
Agreement.

     "Existing SVB Loan Facility" means the loan facility being provided by SVB
to Borrower under the SVB Loan Agreement.

     "Federal Funds Rate" means, for any day, the rate per annum equal to the
weighted average of the rates on overnight Federal funds transactions with
members of the Federal Reserve System arranged by Federal funds brokers on such
day, as published by the Federal Reserve Bank of New York on the Business Day
next succeeding such day; provided that (a) if such day is not a Business Day,
the Federal Funds Rate for such day shall be such rate on such transactions on
the next preceding Business Day as so published on the next succeeding Business
Day, and (b) if no such rate is so published on such next succeeding Business
Day, the Federal Funds Rate for such day shall be the average rate (rounded
upward, if necessary, to a whole multiple of 1/100 of 1%) charged to Lender on
such day on such transactions as determined by Lender.

     "GAAP" means generally accepted accounting principles consistently applied
in the United States.

     "Loan Documents" means this Agreement, the Note, the Warrant, and all other
present or future instruments and agreements between Borrower and Lender
relating hereto or thereto.

     "Material Adverse Change" means (i) a material adverse change in the
business, operations, results of operations, assets, liabilities, condition or
prospects of Borrower, (ii) the material impairment of Borrower's ability to
perform the Obligations, or of Lender to enforce the Obligations or realize upon
the Collateral, or (iii) a material adverse change in the value of the
Collateral or the amount which Lender would be likely to receive in the
liquidation of the Collateral.

     "Obligations" means all present and future Loans, advances, debts,
liabilities, obligations, guaranties, covenants, duties and indebtedness at any
time owing by Borrower or any of its subsidiaries or affiliates to Lender or its
parent or any of its subsidiaries or affiliates, whether evidenced by this
Agreement or any note or other instrument or document, whether arising from an
extension of credit, loan, guaranty, indemnification or otherwise, whether
direct or indirect (including, without limitation, those acquired by assignment
and any participation by Lender in Borrower's indebtedness or obligations owing
to others), absolute or contingent, due or to become due, including, without
limitation, all interest, charges, expenses, fees, attorney's fees, expert
witness fees, audit fees, loan fees, prepayment fees, and any other sums
chargeable to Borrower under this Agreement or under any other present or future
instrument or agreement between Borrower and Lender.

     "Person" means any individual, sole proprietorship, partnership, joint
venture, trust, limited liability company, unincorporated organization,
association, corporation, government, or any agency or political division
thereof, or any other entity.

     "Representations" means the written Representations and Warranties
previously delivered by Borrower to Lender dated as of the date hereof.

     "SVB Loan Agreement" means the Loan and Security Agreement dated August 20,
2002 between Borrower and SVB, as amended by a First Loan Modification Agreement
dated August 5, 2003, and by a Second Loan Modification Agreement dated November
4, 2003, and all modifications permitted hereunder, and all extensions and
renewals thereof.

     "Warrant" means all warrants to purchase stock of the Borrower assigned to
Lender by ORIX previously, now or in the future, and all extensions and renewals
thereof and replacements therefor.

     Other Terms. All accounting terms used in this Agreement, unless otherwise
indicated, shall have the meanings given to such terms in accordance with GAAP.
All other terms contained in this Agreement, unless otherwise indicated, shall
have the meanings provided by the Code, to the extent such terms are defined
therein.

8. GENERAL PROVISIONS.

     8.1 APPLICATION OF PAYMENTS. All payments with respect to the Obligations
may be applied, and in Lender's good faith business judgment reversed and
re-applied, to the Obligations, in such order and manner as Lender shall
determine in its good faith business judgment.

     8.2 CONFIDENTIALITY. Lender agrees to use the same degree of care that they
exercise with respect to its own proprietary information, to maintain the
confidentiality of

                                       -8-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

any and all proprietary, trade secret or confidential information provided to or
received by them from the Borrower, which indicates that it is confidential, or
should reasonably be known by them to be confidential, including business plans
and forecasts, non-public financial information, confidential or secret
processes, formulae, devices and contractual information, customer lists, and
employee relation matters, provided that Lender may disclose such information to
(i) its officers, directors, employees, attorneys, accountants, affiliates,
participants, prospective participants, assignees and prospective assignees,
provided that such Persons agree to hold such information in confidence in
accordance with the terms of this Section 8.2, and (ii) such other Persons to
whom Lender shall at any time be required to make such disclosure in accordance
with applicable law, and provided, that the foregoing provisions shall not apply
to disclosures made by Lender in its good faith business judgment in connection
with the enforcement of its rights or remedies after an Event of Default. The
confidentiality agreement in this Section supersedes any prior confidentiality
agreement of Lender relating to Borrower. This Section 8.2 shall not apply to
information related to the tax treatment or the tax structure of the
transactions contemplated herein.

     8.3 NOTICES. All notices to be given under this Agreement shall be in
writing and shall be given either personally or by reputable private delivery
service or by regular first-class mail, or certified mail return receipt
requested, addressed as follows:

     (a) if to Borrower, at its address shown in the heading to this Agreement,
with a copy to Lawrence S. Wittenberg, Esq., Goodwin Procter LLP, 53 State
Street, Boston, MA 02109;and

     (b) if to Lender, at Bank of America, N.A., Mail Code: MA5-100-07-01, 100
Federal Street, Boston, MA 02110, Attention: Douglas Marshall, with a copy to
Linda J. Groves, Esq., Bingham McCutchen LLP, 150 Federal Street, Boston, MA
02110.

The parties hereto may change the address at which they are to receive notices
hereunder, by notice in writing in the foregoing manner given to all other
parties. All notices shall be deemed to have been given upon delivery in the
case of notices personally delivered, or at the expiration of one Business Day
following delivery to the private delivery service, or two Business Days
following the deposit thereof in the United States mail, with postage prepaid.

     8.4 ATTORNEYS' FEES AND COSTS. Borrower shall reimburse Lender for all
reasonable attorneys' fees (other than attorneys' fees incurred in respect of
the preparation, negotiation and initial closing of this Agreement) and all
filing, recording, search, title insurance, appraisal, audit, and other
reasonable costs incurred by it, pursuant to, or in connection with, or relating
to this Agreement (whether or not a lawsuit is filed), including, but not
limited to, out of pocket costs and expenses in connection with any board of
directors meeting observation rights provided to them under this Agreement, all
reasonable attorneys' fees and costs they incur in order to do the following:
obtain legal advice in connection with this Agreement or Borrower; enforce, or
seek to enforce, any of its rights; commence, intervene in, or defend any action
or proceeding; initiate any complaint to be relieved of the automatic stay in
bankruptcy; file or prosecute any probate claim, bankruptcy claim, third-party
claim, or other claim; protect, obtain possession of, lease, dispose of, or
otherwise enforce its security interests in, the Collateral; and otherwise
represent Lender in any litigation relating to Borrower under or in connection
with this Agreement or any other Loan Document. If a party hereto files any
lawsuit against another party predicated on a breach of this Agreement, the
prevailing party in such action shall be entitled to recover its reasonable
costs and attorneys' fees from the non-prevailing party, including (but not
limited to) reasonable attorneys' fees and costs incurred in the enforcement of,
execution upon or defense of any order, decree, award or judgment.

     8.5 WAIVERS. The failure of Lender at any time or times to require Borrower
to strictly comply with any of the provisions of this Agreement or any other
present or future agreement between Borrower and Lender shall not waive or
diminish any right of Lender later to demand and receive strict compliance
therewith. Any waiver of any default shall not waive or affect any other
default, whether prior or subsequent, and whether or not similar. None of the
provisions of this Agreement or any other agreement now or in the future
executed by Borrower and delivered to Lender shall be deemed to have been waived
by any act or knowledge of Lender or its agents or employees, but only by a
specific written waiver signed by an authorized officer of Lender and delivered
to Borrower. Borrower waives the benefit of all statutes of limitations relating
to any of the Obligations or this Agreement or any other Loan Document, and
Borrower waives demand, protest, notice of protest and notice of default or
dishonor, notice of payment and nonpayment, release, and notice of any action
taken by Lender, unless expressly required by this Agreement. NEITHER LENDER NOR
ANY OF ITS AFFILIATES, SUBSIDIARIES, DIRECTORS, OFFICERS, EMPLOYEES, AGENTS OR
ATTORNEYS SHALL BE RESPONSIBLE OR LIABLE TO BORROWER OR TO ANY OTHER PARTY FOR
INDIRECT, PUNITIVE, EXEMPLARY OR CONSEQUENTIAL DAMAGES WHICH MAY BE ALLEGED AS A
RESULT OF ANY FINANCIAL ACCOMMODATION HAVING BEEN EXTENDED, SUSPENDED OR
TERMINATED UNDER THIS AGREEMENT OR ANY OTHER OR AS A RESULT OF ANY OTHER
TRANSACTION CONTEMPLATED HEREUNDER OR THEREUNDER.

     8.6 PUBLIC ANNOUNCEMENT. Borrower hereby agrees that Lender may make a
public announcement of the

                                       -9-

<PAGE>

                                                     LOAN AND SECURITY AGREEMENT

transactions contemplated by this Agreement, and may publicize the same in
marketing materials, newspapers and other publications, and otherwise, and in
connection therewith may use the Borrower's name, tradenames and logos.

     8.7 GENERAL. The provisions of this Agreement shall be binding upon and
inure to the benefit of the respective successors, assigns, and representatives
of Borrower and Lender; provided, however, that Borrower may not assign or
transfer any of its rights under this Agreement without the prior written
consent of Lender and any prohibited assignment shall be void. Lender may from
time to time, with prior notice to the Borrower, assign to one or more Persons
all or a portion of its rights and obligations under this Agreement; provided
that Lender may at any time pledge or assign a security interest in all or any
portion of its rights under this Agreement to secure obligations of Lender to a
Federal Reserve Bank without notice to Borrower. No consent by Lender to any
assignment shall release Borrower from its liability for the Obligations. If
Borrower consists of more than one Person, their liability shall be joint and
several, and the compromise of any claim with, or the release of, any Borrower
shall not constitute a compromise with, or a release of, any other Borrower.
This Agreement and all acts, transactions disputes and controversies arising
hereunder or relating hereto, and all rights and obligations of Lender and
Borrower shall be governed by, and construed in accordance with the internal
laws (and not the conflict of laws rules) of the Commonwealth of Massachusetts.
Borrower (i) agrees that all actions and proceedings relating directly or
indirectly to this Agreement shall, at Lender's option, be litigated in courts
located within the Commonwealth of Massachusetts; (ii) consents to the
jurisdiction and venue of any such court and consents to service of process in
any such action or proceeding by personal delivery or any other method permitted
by law; and (iii) waives any and all rights Borrower may have to object to the
jurisdiction of any such court, or to transfer or change the venue of any such
action or proceeding. Paragraph headings are only used in this Agreement for
convenience, and shall not be used in any manner to construe, limit, define or
interpret any term or provision of this Agreement. The term "including",
whenever used in this Agreement, shall mean "including (but not limited to)".
This Agreement has been fully reviewed and negotiated between the parties and no
uncertainty or ambiguity in any term or provision of this Agreement shall be
construed strictly against Lender or Borrower under any rule of construction or
otherwise. Should any provision of this Agreement be held by any court of
competent jurisdiction to be void or unenforceable, such defect shall not affect
the remainder of this Agreement, which shall continue in full force and effect.
This Agreement may be executed and delivered by the signing and delivery of this
Agreement with original signatures or by facsimile copy. This Agreement and such
other written agreements, documents and instruments as may be executed in
connection herewith, including without limitation the Representations, are the
final, entire and complete agreement among Borrower and Lender and supersede all
prior and contemporaneous negotiations and oral representations and agreements,
all of which are merged and integrated in this Agreement. There are no oral
understandings, representations or agreements between the parties which are not
set forth in this Agreement or in other written agreements signed by the parties
in connection herewith. The terms and provisions of this Agreement may not be
waived or amended, except in a writing executed by Borrower and a duly
authorized officer of Lender. Time is of the essence in the performance by
Borrower of each and every obligation under this Agreement.

     8.8 MUTUAL WAIVER OF JURY TRIAL. BORROWER AND LENDER EACH HEREBY WAIVE THE
RIGHT TO TRIAL BY JURY IN ANY ACTION OR PROCEEDING BASED UPON, ARISING OUT OF,
OR IN ANY WAY RELATING TO, THIS AGREEMENT OR ANY OTHER PRESENT OR FUTURE
INSTRUMENT OR AGREEMENT BETWEEN LENDER AND BORROWER, OR ANY CONDUCT, ACTS OR
OMISSIONS OF LENDER OR BORROWER OR ANY OF THEIR DIRECTORS, OFFICERS, EMPLOYEES,
AGENTS, ATTORNEYS OR ANY OTHER PERSONS AFFILIATED WITH LENDER OR BORROWER, IN
ALL OF THE FOREGOING CASES, WHETHER SOUNDING IN CONTRACT OR TORT OR OTHERWISE.

     8.9. USA PATRIOT ACT NOTICE. Lender hereby notifies the Borrower that
pursuant to the requirements of the USA Patriot Act (Title III of Pub. L. 107-56
(signed into law October 26, 2001)) (the "Act"), it is required to obtain,
verify and record information that identifies the Borrower, which information
includes the name and address of the Borrower and other information that will
allow Lender to identify the Borrower in accordance with the Act.

                                      -10-

<PAGE>

BORROWER:

ATHENAHEALTH, INC.

BY: /s/ Carl Byers
    ---------------------------------
NAME: Carl Byers
TITLE: Treasurer & CFO

LENDER:

BANK OF AMERICA, N.A.

BY /s/ Stacy Benham
   ---------------------------------
   Stacy Benham
   VP/Credit Products Officer

                  Signature page to Loan and Security Agreement
<PAGE>

                                   SCHEDULE TO

                           LOAN AND SECURITY AGREEMENT

BORROWER: ATHENAHEALTH, INC.

ADDRESS:  311 ARSENAL STREET
          WATERTOWN, MASSACHUSETTS 02472

DATE:     MARCH 31, 2006

This Schedule is an integral part of the Loan and Security Agreement among Bank
of America, N.A. ("Lender") and the borrower named above ("Borrower") of even
date.

<TABLE>
<S>                              <C>
1. LOANS (Section 1.1):

     (a)  Equipment Loans.       Loans (the "Equipment Loans") in the total
                                 amount of $2,741,505.03, which shall be subject
                                 to the following terms:

                                 (1)  Equipment Loans may not be reborrowed
                                      after they have been repaid.

                                 (2)  The Borrower shall repay to the Lender the
                                      principal amount of the Equipment Loan in
                                      monthly installments. Such monthly
                                      installments ("Equipment Loan
                                      Installments") of principal shall be
                                      payable on the installment payment dates
                                      (each a "Equipment Loan Installment
                                      Date"), and shall be in the amounts as set
                                      forth in the table below as adjusted in
                                      accordance with the terms of this
                                      Agreement, with all remaining outstanding
                                      amounts of the Equipment Loans to be
                                      repaid on the Maturity Date.

                                       EQUIPMENT LOAN      EQUIPMENT LOAN
                                      INSTALLMENT DATE      INSTALLMENTS
                                      ----------------   -----------------
                                           4/1/06            $99,385.65
                                           5/1/06            $99,385.65
                                           6/1/06            $99,385.65
                                           7/1/06            $99,385.65
                                           8/1/06            $99,385.65
                                           9/1/06            $99,385.65
                                           10/1/06           $99,385.65
                                           11/1/06           $99,385.65
                                           12/1/06           $99,385.65
                                           1/1/07            $99,385.65
</TABLE>

                                      -1-

<PAGE>

                                 SCHEDULE TO LOAN AND SECURITY AGREEMENT

<TABLE>
<S>                              <C>
                                           2/1/07            $99,385.65
                                           3/1/07            $99,385.65
                                           4/1/07            $99,385.65
                                           5/1/07            $99,385.65
                                           6/1/07            $99,385.65
                                           7/1/07            $99,385.65
                                           8/1/07            $99,385.65
                                           9/1/07            $99,385.65
                                           10/1/07           $99,385.65
                                           11/1/07           $99,385.65
                                           12/1/07           $99,385.65
                                           1/1/08            $99,385.65
                                           2/1/08            $99,385.78
                                           3/1/08            $69,391.47
                                           4/1/08            $69,391.47
                                           5/1/08            $69,391.47
                                           6/1/08            $69,391.52
                                           7/1/08            $54,525.59
                                           8/1/08            $54,525.75
                                           9/1/08            $29,270.03
                                           10/1/08           $13,249.19
                                           11/1/08           $13,249.19
                                           12/1/08       $13,249.27 or the
                                                         remaining balance
                                                         of the Equipment
                                                               Loans

                                 (3)  Interest accrued on the Equipment Loans
                                      for each month shall be payable monthly no
                                      later than the fifth day of the following
                                      month, and at maturity.

2. INTEREST. (Section 1.3)
</TABLE>

                                      -2-

<PAGE>

                                         SCHEDULE TO LOAN AND SECURITY AGREEMENT

<TABLE>
<S>                              <C>
     (a)  Equipment Loans.       The interest rate applicable to the Equipment
                                 Loans in effect throughout each calendar month
                                 shall be the Base Rate plus 3.75%, provided
                                 that the interest rate in effect on each day
                                 shall not be less than 9% per annum.

     (b)  General.               All interest shall be calculated on the basis
                                 of a 360-day year for the actual number of days
                                 elapsed. Base Rate has the meaning set forth in
                                 Section 7 above.

3. [INTENTIONALLY OMITTED]

4. MATURITY DATE
   (Section 5.1):                DECEMBER 1, 2008

5. REPORTING
   (Section 4.2):                Borrower, at its expense, shall provide Lender
                                 with the reports shown in Section 4.2 of the
                                 Loan Agreement and the following on a
                                 consolidated basis:

                                 (a)  Monthly unaudited financial statements
                                      within 30 days after the end of each
                                      month;

                                 (b)  Quarterly unaudited financial statements
                                      within 30 days after the end of each
                                      fiscal quarter;

                                 (c)  Annual, unqualified financial statements,
                                      audited by independent certified public
                                      accountants acceptable to Lender (provided
                                      that Lender hereby agrees that Borrower's
                                      existing accountants are acceptable
                                      hereunder), within 120 days after the end
                                      of each fiscal year of Borrower

                                 (d)  A Certificate, confirming no Defaults or
                                      Events of Default have occurred and are
                                      continuing, in such form as Lender shall
                                      specify from time to time, which shall be
                                      provided with the financial statements
                                      referred to in Sections 5(b) and (c)
                                      above.

6. ADDITIONAL PROVISIONS.

                                           (a)  WARRANTS. The Borrower hereby
                                                (a) acknowledges that ORIX has
                                                agreed to, within fifteen (15)
                                                days of the date hereof, assign
                                                to Lender, warrants to purchase
                                                5,000 shares of Series E
                                                Preferred Stock of Borrower at a
                                                purchase price of $5.04 per
                                                share, on the terms set forth in
                                                the Warrant to Purchase Stock,
                                                dated February 28, 2005 (the
                                                "Warrant Agreement"), (b) agrees
                                                that, notwithstanding Section
                                                4.3 of the Warrant Agreement, it
                                                will not require ORIX or Lender
                                                to provide an opinion of counsel
                                                in connection with such
                                                assignment and (c) agrees that
                                                within three Business Day after
                                                receiving notice from Lender or
                                                ORIX of the effectiveness of
                                                such assignment, it shall
                                                reissue Warrants to ORIX and
                                                Lender, reflecting the
                                                assignment.

                                           (b)  CORPORATE STRUCTURE. Borrower
                                                represents and warrants that
                                                Borrower has no partially or
                                                wholly-owned subsidiaries,
                                                except for one wholly-owned
                                                Indian company (the "Indian
                                                Sub"). Borrower shall not permit
                                                the Indian Sub at any time to
                                                have total assets in excess of
</TABLE>

                                      -3-

<PAGE>

                                         SCHEDULE TO LOAN AND SECURITY AGREEMENT

<TABLE>
<S>                              <C>
                                                $250,000 (which amount may be
                                                increased from time to time,
                                                with Lender's prior written
                                                consent, as to which Lender
                                                shall exercise its good faith
                                                business judgment). All
                                                intellectual property developed
                                                by the Indian Sub shall at all
                                                times be owned by Borrower.
</TABLE>

                                      -4-

<PAGE>

Borrower:                               LENDER:
ATHENAHEALTH, INC.                      BANK OF AMERICA, N.A.

By /s/ Carl Byers                       By /s/ Stacy Benham
   ----------------------------------      -------------------------------------
Name: Carl Byers                           Stacy Benham
Title: Treasurer & CFO                     VP/Credit Products Officer

            Signature page to Schedule to Loan and Security Agreement

<PAGE>

                                    Exhibit A

                              DISCLOSURE SCHEDULES

                                     TO THE

                      EQUIPMENT LOAN AND SECURITY AGREEMENT<PAGE>

                                                                   EXHIBIT 10.24

                               EQUIPMENT LOAN NOTE

$2,741,505.03                                                     March 31, 2006

     FOR VALUE RECEIVED, the undersigned ATHENAHEALTH, INC. (the "Borrower"), a
Delaware corporation, hereby promises to pay to the order of BANK OF AMERICA,
N.A. (the "Bank") at the Bank's office at 100 Federal Street, Boston MA 02110:

          (a) prior to or on the Maturity Date the principal amount of TWO
     MILLION SEVEN HUNDRED FORTY-ONE THOUSAND FIVE HUNDRED FIVE DOLLARS and
     THREE CENTS ($2,741,505.03), evidencing the Equipment Loans under the Loan
     and Security Agreement dated as of March 31, 2006 (as amended and in effect
     from time to time, the "Credit Agreement"), by and among the Borrower and
     the Bank;

          (b) the principal outstanding hereunder from time to time at the times
     provided in the Credit Agreement; and

          (c) interest from the date hereof on the principal amount from time to
     time outstanding to and including the maturity hereof at the rates and
     terms and in all cases in accordance with the terms of the Credit
     Agreement.

     This Note evidences borrowings under and has been issued by the Borrower in
accordance with the terms of the Credit Agreement. The Bank and any holder
hereof is entitled to the benefits of the Credit Agreement and the other Loan
Documents, and may enforce the agreements of the Borrower contained therein, and
any holder hereof may exercise the respective remedies provided for thereby or
otherwise available in respect thereof, all in accordance with the respective
terms thereof. All capitalized terms used in this Note and not otherwise defined
herein shall have the same meanings herein as in the Credit Agreement.

     The Borrower irrevocably authorizes the Bank to make or cause to be made,
at the time of receipt of any payment of principal of this Note, an appropriate
notation on the grid attached to this Note, or the continuation of such grid, or
any other similar record, including computer records, reflecting the receipt of
such payment. The outstanding amount of the Equipment Loans set forth on the
grid attached to this Note, or the continuation of such grid, or any other
similar record, including computer records, maintained by the Bank with respect
to the Equipment Loans shall be prima facie evidence of the principal amount of
the Equipment Loans owing and unpaid to the Bank, but the failure to record, or
any error in so recording, any such amount on any such grid, continuation or
other record shall not limit or otherwise affect the obligation of the Borrower
hereunder or under the Credit Agreement to make payments of principal of and
interest on this Note when due.

     The Borrower has the right in certain circumstances and the obligation
under certain other circumstances to prepay the whole or part of the principal
of this Note on the terms and conditions specified in the Credit Agreement.

     If any one or more of the Events of Default shall occur, the entire unpaid
principal amount of this Note and all of the unpaid interest accrued thereon may
become or be declared due and payable in the manner and with the effect provided
in the Credit Agreement.

<PAGE>

                                       -2-

     No delay or omission on the part of the Bank or any holder hereof in
exercising any right hereunder shall operate as a waiver of such right or of any
other rights of the Bank or such holder, nor shall any delay, omission or waiver
on any one occasion be deemed a bar or waiver of the same or any other right on
any future occasion.

     The Borrower hereby waives presentment, demand, notice, protest and all
other demands and notices in connection with the delivery, acceptance,
performance, default or enforcement of this Note, and assents to any extension
or postponement of the time of payment or any other indulgence, to any
substitution, exchange or release of collateral and to the addition or release
of any other party or person primarily or secondarily liable.

     THIS NOTE AND THE OBLIGATIONS OF THE BORROWER HEREUNDER SHALL FOR ALL
PURPOSES BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAW OF THE
COMMONWEALTH OF MASSACHUSETTS (EXCLUDING THE LAWS APPLICABLE TO CONFLICTS OR
CHOICE OF LAW). THE BORROWER AGREES THAT ANY SUIT FOR THE ENFORCEMENT OF THIS
NOTE MAY BE BROUGHT IN THE COURTS OF THE COMMONWEALTH OF MASSACHUSETTS OR ANY
FEDERAL COURT SITTING THEREIN AND THE CONSENT TO THE NONEXCLUSIVE JURISDICTION
OF SUCH COURT AND THE SERVICE OF PROCESS IN ANY SUCH SUIT BEING MADE UPON THE
BORROWER BY MAIL AT THE ADDRESS SPECIFIED IN SECTION 8.3 OF THE CREDIT
AGREEMENT. THE BORROWER HEREBY WAIVES ANY OBJECTION THAT IT MAY NOW OR HEREAFTER
HAVE TO THE VENUE OF ANY SUCH SUIT OR ANY SUCH COURT OR THAT SUCH SUIT IS
BROUGHT IN AN INCONVENIENT COURT.

     This Note shall be deemed to take effect as a sealed instrument under the
laws of the Commonwealth of Massachusetts.

<PAGE>

     IN WITNESS WHEREOF, the undersigned has caused this Note to be signed by
its duly authorized officer as of the day and year first above written.

                                        ATHENAHEALTH, INC.

                                        By: /s/ Carl Byers
                                            ------------------------------------
                                        Name: Carl Byers
                                        Title: Treasurer & CFO

                     Signature page to Equipment Loan Note

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00126-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00126-of-00352.parquet"}]]