Document:

Officer's Certificate of the Registrant pursuant to Section 2.08

 Exhibit 4.1 
 ASTRAZENECA PLC 
 OFFICERS’ CERTIFICATE 

In connection with the issuance of the 1.95% Notes due 2019 (the “2019 Notes”) and the 4.00% Notes due 2042 (the “2042
Notes” and, together with the 2019 Notes, the “Notes” or the “Securities”) of AstraZeneca PLC (the “Issuer”) pursuant to the Indenture, dated as of April 1, 2004 (the
“Indenture”), between the Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor Trustee (section references herein being to the Indenture), and pursuant to the authorization of the Board of
Directors of the Issuer by written resolution effective from September 5, 2012, the undersigned hereby confirms that, to the extent not otherwise provided for in the Indenture, the following forms, terms and conditions of the Notes were
established as required pursuant to Section 2.01 and Section 2.08 of the Indenture: 
  

	 Title of Notes: 
	1.95% Notes due 2019 

 4.00% Notes due 2042 

 

	 Initial Aggregate Principal Amount of Notes: 
	2019 Notes: US$ 1,000,000,000  

 2042
Notes: US$ 1,000,000,000 
  

	 Price to Public:  
	2019 Notes: 99.876% of the Principal Amount per 2019 Note, plus accrued interest, if any, from September 18, 2012 

 

	 	2042 Notes: 99.377% of the Principal Amount per 2042 Note, plus accrued interest, if any, from September 18, 2012 

 

	 Issue Date:  
	2019 Notes: September 18, 2012  

2042 Notes: September 18, 2012 
  

	 Form of Notes: 
	The Notes will be issued in the form of global notes that will be deposited with The Depositary Trust Company, New York, New York (“DTC”) on the closing date. Four global notes
will be issued to DTC, which will be executed and delivered in substantially the form of Notes set forth in Exhibits A and B hereto. In certain circumstances described in the Indenture, Notes may be issued in definitive form.

  

	 Maturity:  
	2019 Notes: September 18, 2019  

2042 Notes: September 18, 2042 
  

	 Interest Rate:  
	2019 Notes: 1.95% per annum, accruing from September 18, 2012  

 2042 Notes: 4.00% per annum, accruing from September 18, 2012 
  

	 Interest Periods: 
	The first interest period will be the period from and including the original issue date to but excluding the Interest Payment Date (as defined below). Thereafter, the interest periods will be
the periods from and including the Interest Payment Dates to but excluding the immediately succeeding Interest Payment Date (each, an “Interest Period”). The final Interest Period will be the period from and including the Interest
Payment Date immediately preceding the maturity date to the maturity date. 

	 Interest Payment Dates: 
	Interest shall be payable semiannually in arrears on September 18 and March 18 of each year, commencing on March 18, 2013 (each, an “Interest Payment Date”).

  

	 	Notwithstanding the above, if the relevant Interest Payment Date is not a Business Day (as defined below), such Interest Payment Date shall be postponed to the next
Business Day. 

  

	 Regular Record Dates: 
	Interest shall be paid to the holder in whose name the Notes are registered at the close of business on the 15th calendar day preceding each Interest Payment Date (whether or not a Business Day). 

 

	 Business Day: 
	Any day which is not, in London, England or New York, New York, or the place of payment of amounts payable in respect of the Notes, a Saturday, a Sunday, a legal holiday or a day on which
banking institutions are authorized or obligated by law, regulation or executive order to close. 

  

	 Place of Payment, Registration of Transfer and Exchange, Paying Agent, Calculation Agent: 
	The Bank of New York Mellon
 101 Barclay Street
 New York, NY 10286 

  

	 Trustee: 
	The Bank of New York Mellon 

  

	 Notice and Demands to Issuer: 
	AstraZeneca PLC 

 2 Kingdom Street 

London W2 6BD 

England 
 Attn:
The Company Secretary 
 Redemption Provisions: 

 

	 Optional Tax Redemption for any series
 of Notes: 
	Optional, in whole but not in part, at the option of the Issuer, at any time in accordance with the terms set forth in the relevant form of Notes set forth in Exhibits A and B hereto.

  

	 Optional Redemption for any series of Notes: 
	Optional, in whole or in part, at the option of the Issuer, at any time and from time to time, in accordance with Section 11.02 of the Indenture, at a redemption price (the
“Redemption Price”) equal to the greater of: 

  

	 	(i)	100% of the principal amount of the series of Notes to be redeemed, and 

  

	 	(ii)	 as determined by the Quotation Agent (as defined below), the sum of the present values of the remaining scheduled

  
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payments of principal and interest thereon (not including any portion of such payments of interest accrued as of the date of redemption) discounted to the date of redemption on a semiannual basis
(assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate plus the Make-Whole Spread (as set forth below), 

  

	 	plus, in each case, accrued interest thereon to the date of redemption. 

  

	 	“Treasury Rate” means, with respect to any redemption date, the rate per annum equal to the semiannual equivalent yield to maturity of the Comparable
Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such redemption date. 

 

	 	“Comparable Treasury Issue” means the United States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining
term of the applicable series of Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining
term of such series of Notes. 

  

	 	“Comparable Treasury Price” means, with respect to any redemption date, (i) the average of the Reference Treasury Dealer Quotations for such
redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if the Trustee obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations.

  

	 	“Quotation Agent” means the Reference Treasury Dealer appointed by the Issuer. 

 

	 	“Reference Treasury Dealer” means (i) each of Goldman, Sachs & Co, HSBC Securities (USA) Inc., J.P. Morgan Securities LLC, and Morgan
Stanley & Co. LLC, and their respective successors or affiliates; provided, however, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”),
the Issuer shall substitute therefor another Primary Treasury Dealer; and (ii) any other Primary Treasury Dealer selected by the Issuer. 

  

	 	 “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any redemption date, the average, as determined by
the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing 

  
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to the Trustee by such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding such redemption date. 

 

	 	“Make-Whole Spread” means, with respect to, (i) the 2019 Notes, 15 basis points and (ii) the 2042 Notes, 20 basis points.

  

	 Redemption Notices: 
	Notice of any redemption will be mailed at least 30 days but not more than 60 days prior to the redemption date to the Holders. Unless the Issuer defaults in payment of the Redemption Price, on
and after the redemption date, interest will cease to accrue on the Notes or portions thereof called for redemption. 

  

	 Defeasance and Discharge of the 
	Applicable. 

 Notes (Section 9.03): 

 

	 Sinking Fund: 
	None. 

  

	 Additional Amounts: 
	Pursuant to the relevant form of Notes set forth in Exhibits A and B hereto, the Issuer may, subject to certain exceptions, be obligated to pay additional amounts. 

 

	 Other Terms of the Notes: 
	The other terms of the Notes shall be substantially as set forth in the Indenture, the relevant form of Notes attached hereto as Exhibits A and B, the Prospectus dated December 21, 2010
(the “Prospectus”) relating to the Notes and the Prospectus Supplement dated September 11, 2012 to the Prospectus. 

  
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 Each of the undersigned hereby certifies that: 

1. He has read the provisions of the Indenture setting forth covenants and conditions to the Trustee’s authentication and delivery of the Securities
and the definitions in the Indenture relating thereto. 
 2. He has examined the resolutions of the Board of Directors of the Issuer adopted
prior to the date hereof relating to the authorization, issuance, authentication and delivery of the Securities, such other corporate records of the Issuer, as applicable, and such other documents deemed necessary as a basis for the opinion
hereinafter expressed. 
 3. In his opinion, such examination is sufficient to enable him to express an informed opinion as to whether or not the
covenants and conditions referred to above have been complied with. 
 4. He is of the opinion that the covenants and conditions referred to
above have been complied with. 

  
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 IN WITNESS WHEREOF, each of the undersigned has hereunto signed his name. 

Dated: September 18, 2012 
  

	
	 /s/ Simon Lowth

	Name: Simon Lowth
	Title: Interim CEO, Director

  

	
	 /s/ Adrian Kemp

	Name: Adrian Kemp
	Title: Company Secretary

 Exhibit A 
 FORM OF 2019 NOTE 
 THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE MEANING OF
THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 ASTRAZENECA PLC 
 1.95% Notes due 2019 

 

					
	No. [001]	 		 	$500,000,000

 CUSIP No. 046353 AF5 
 ISIN No. US046353AF58 
 ASTRAZENECA PLC, a public limited
company incorporated under the laws of England and Wales (herein called the “Issuer”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co.,
or registered assigns, the principal sum of Five Hundred Million Dollars on September 18, 2019 and to pay interest thereon from September 18, 2012 or from the most recent Interest Payment Date (as defined below) to which interest has been
paid or duly provided for, semiannually in arrears on September 18 and March 18 in each year, commencing March 18, 2013 (each, an “Interest Payment Date”), at the rate of 1.95% per annum, until the principal hereof is
paid or made available for payment The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on the Regular Record Date (as defined below) for such interest which shall be the 15th calendar day preceding such Interest Payment Date (whether or not such day is a Business Day (as defined below)), as
the case may be. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a subsequent record date (the “Special Record Date”) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business Days prior to the
date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Payment of the principal of (and premium, if any) and any such interest on this Security
will be made at the office or agency of the Issuer maintained for that purpose in New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts;
provided, however, that at the option of the Issuer payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for
all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been
executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
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 IN WITNESS WHEREOF, the Issuer has caused this instrument to be duly executed manually or in
facsimile. 
 Dated: September 18, 2012 

 

			
	ASTRAZENECA PLC
		
	By:	 	 
	 Name:
 Title:
	 	 Simon Lowth
 Interim CEO,
Director

 
			
	
		
	By:	 	 
	 Name:
 Title:
	 	 Adrian Kemp

Company Secretary

 This is one of the Securities of the series designated herein and referred to in the
within-mentioned Indenture. 
 Dated: September 18, 2012 

 

			
	 THE BANK OF NEW YORK MELLON
 As Trustee

		
	 By:
	 	 
		 	

  
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 This Security is one of a duly authorized issue of securities of the Issuer (herein called
the “Securities”), issued and to be issued in one or more series under an Indenture, dated as of April 1, 2004 (herein called the “Indenture” which term shall have the meaning assigned to it in such instrument), among the
Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor Trustee (herein called the “Trustee”, which term includes any other successor trustee under the Indenture) to JPMorgan Chase Bank, and reference
is hereby made to the Indenture and to the Officers’ Certificate delivered pursuant to Section 2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and immunities
thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S. $1,000,000,000. 
 The Securities of this series are subject to redemption, as a whole or
in part, at any time and from time to time, at the election of the Issuer, upon not less than 30 nor more than 60 days’ notice, at a Redemption Price equal to the greater of (i) 100% of the principal amount of the Securities to be
redeemed, and (ii) as determined by the Quotation Agent (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest accrued as
of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate plus 15 basis points plus, in each of cases (i) and (ii) above, accrued
interest thereon to the date of redemption. 
 “Treasury Rate” means, with respect to any redemption date, the rate
per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such
redemption date. 
 “Comparable Treasury Issue” means the United States Treasury security selected by the Quotation
Agent as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means, with respect to
any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if
the Trustee obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Issuer. 

  
 4 

 “Reference Treasury Dealer” means (i) each of Goldman, Sachs & Co.,
HSBC Securities (USA) Inc., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC, and their respective successors; provided, however, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New York
City (a “Primary Treasury Dealer”), the Issuer shall substitute therefor another Primary Treasury Dealer; and (ii) any other Primary Treasury Dealer selected by the Issuer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any redemption date, the
average, as determined by the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Trustee by such Reference Treasury Dealer at 5:00
p.m., New York City time, on the third Business Day preceding such redemption date. 
 “Business Day” means any day
which is not, in London, England or New York, New York, or the place of payment of amounts payable in respect of the Notes, a Saturday, a Sunday, a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation
or executive order to close. 
 The Securities may be redeemed at the option of the Issuer, in whole but not in part, upon not
less than 30 nor more than 60 days’ notice given as provided in the Indenture, at any time at a Redemption Price equal to the principal amount thereof plus accrued interest to the date fixed for redemption if (a) as a result of a change in
or any amendment to the laws or any regulations or rulings promulgated thereunder of the jurisdiction in which the Issuer is resident for tax purposes (or of any political subdivision or taxing authority thereof or therein) (or in the case of a
successor Person to the Issuer of the jurisdiction in which such successor Person is organized or any political subdivision or taxing authority thereof or therein) or any change in an application or interpretation of such laws, regulations or
rulings, or any change in an application or interpretation of, or any execution of or amendment to, any treaty or treaties affecting taxation to which the jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or
taxing authority thereof or therein (or such other jurisdiction or political subdivision or taxing authority) is a party, which change, amendment application, interpretation or execution becomes effective on or after September 11, 2012 (or, in
the case of a successor Person to the Issuer, the date on which such successor Person became such pursuant to the applicable provision of the Indenture), the Issuer would be required to pay Additional Amounts, as described below or (b) the
Issuer has been advised by its independent legal adviser that, as a result of any action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, the jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision thereof (or in the case of a successor Person to the Issuer of the jurisdiction in which such successor Person is organized or any political subdivision thereof) (whether or not such action was taken or brought
with respect to the Issuer), which action is taken or brought on or after September 11, 2012 (or, in the case of a successor Person to the Issuer, the date on which such successor Person became such pursuant to the applicable

  
 5 

 
provision of the Indenture), the Issuer will be required to pay Additional Amounts, as described below, and the payment of such Additional Amounts cannot be avoided by the use of any reasonable
measures available to the Issuer. Prior to any redemption of such a series of Securities, the Issuer shall provide the Trustee with an Opinion of Counsel that the conditions precedent to the right of the Issuer to redeem such Securities pursuant to
this paragraph have occurred. Such Opinion of Counsel shall be based on the laws in effect on the date of such opinion or to become effective on or before the next succeeding date for payment of principal or interest. 

In the event of redemption of this Security in part only, a new Security or Securities of this series and of like tenor for the
unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 The Indenture
contains provisions for defeasance at any time of the entire indebtedness on this Security upon compliance by the Issuer with certain conditions set forth thereon, which provisions apply to this Security. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this
series may be declared due and payable in the manner and with the effect provided in the Indenture. 
 If any deduction or
withholding for any present or future taxes, levies, duties, assessments, imposts or other governmental charges whatsoever imposed, assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is
resident for tax purposes (or any political subdivision or taxing authority thereof or therein) shall at any time be required from any amounts to be paid by the Issuer under the Securities, the Issuer (subject to compliance by the Holder of such
Securities with any administrative requirements) will pay to the Holder of this Security, such additional amounts (“Additional Amounts”) as will result in the receipt of such amounts as would have been received by the Holder had no such
withholding or deduction been required; provided, however, that the Issuer shall not be required to make any payment of additional amounts for or on account of: 
 (1) any present or future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that the Holder of the relevant Security (or a
fiduciary, settlor, beneficiary, member or shareholder of, or possessor of a power over, such Holder, if such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident of, or engaging or having been
engaged in a trade or business or maintaining or having maintained a permanent establishment or being or having been physically present in, the jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or taxing
authority thereof or therein or otherwise having or having had some connection with the jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or taxing authority thereof or therein other than the holding or
ownership of a Security, or the collection of principal of, premium, if any, or interest, if any, on, or the enforcement of, a Security; 

  
 6 

 (2) any present or future tax, levy, impost or other governmental charge which would not
have been so imposed, assessed, levied or collected but for the fact that, where presentation is required, the relevant Security was presented more than thirty days after the date on which such payment became due or was provided for, whichever is
later; 
 (3) any estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other
governmental charge; 
 (4) any present or future tax, levy, impost or other governmental charge which is payable in a manner
that does not involve deduction or withholding from payments on or in respect of the relevant Security; 
 (5) any present or
future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the failure of the Holder or beneficial owner of the relevant Security to comply with any certification, identification
or other reporting requirements concerning the nationality, residence, identity or connection with any jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or taxing authority thereof or therein, if compliance
is required by treaty or by statute, regulation or administrative practice of such jurisdiction or any such political subdivision or taxing authority thereof or therein as a condition to relief or exemption from such tax, levy, impost or other
governmental charge; 
 (6) any present or future tax, levy, impost or other governmental charge is imposed on a payment to an
individual and is required to be made pursuant to European Council Directive 2003/48/EC or any other European Union Directive implementing the conclusions of the ECOFIN Council meeting of 26-27 November 2000 on the taxation of savings or any
law implementing or complying with, or introduced in order to conform to, such Directive; 
 (7) any present or future tax,
levy, impost or other governmental change which a Holder would have been able to avoid by presenting the relevant debt security to another paying agent in a Member State of the European Union or elsewhere; 

(8) any present or future tax, levy, impost or other governmental change which a Holder would have been able to avoid by authorizing the
paying agent to report information in accordance with the procedure laid down by the relevant tax authority or by producing, in the form requested by the relevant tax authority, a declaration, claim, certificate, document or other evidence
establishing exemption therefrom; 

  
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 (9) any present or future tax, levy, impost or other governmental charge imposed, assessed,
levied or collected in respect of a payment under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the sole beneficial owner of such payment or Security to the extent that
the beneficiary or settlor with respect to the fiduciary, member of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such tax, levy, impost or charge, had that beneficiary,
settlor, member or beneficial owner been the actual Holder of such Security; or 
 (10) any combination of items
(1) through (9) above. 
 The foregoing provisions shall apply mutatis mutandis to any withholding or deduction for or on account of
any present or future taxes, assessments or governmental charges of whatever nature of any jurisdiction in which any successor Person to the Issuer is organized, or any political subdivision or taxing authority thereof or therein. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Issuer and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the consent of the Holders of a majority in principal amount of the Securities
at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of each series at the time Outstanding, on behalf of the Holders of
all Securities of such series to waive compliance by the Issuer with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is
made upon this Security. 
 As set forth in, and subject to, the provisions of the Indenture, no Holder of any Security of this
series will have any right to institute any proceeding with respect to the Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with
respect to the Securities of this series, the Holders of not less than 25% in principal amount of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee to institute such
proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; provided, however, that such limitations do not apply to a suit instituted by the Holder hereof for the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the
respective due dates expressed herein. 

  
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 No reference herein to the Indenture and no provision of this Security or of the Indenture
shall alter or impair the obligation of the Issuer, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed or to convert
this Security as provided in the Indenture. 
 The Securities of this series are issuable only in registered form without
coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 
 No service charge shall be made for
any such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentation of this Security for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the
Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of the Issuer nor the Trustee nor any such agent shall be affected by notice to the
contrary. 
 This Security shall be governed by and construed in accordance with the laws of the State of New York.

 Unless otherwise defined herein, all terms used in this Security which are defined in the Indenture shall have the
meanings assigned to them in the Indenture. 

  
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 SCHEDULE OF PRINCIPAL AMOUNT 

The initial principal amount of this Security shall be $500,000,000. The following decreases/increases in the principal amount of this
Security have been made: 
  

																	
	 Date of

Decrease/Increase
	  	 	  	 Decrease in

Principal

Amount
	  	 	  	 Increase in

Principal

Amount
	  	 	  	 Total Principal

Amount

Following such
 Decrease/Increase
	  	 	  	 Notation Made

by or on Behalf
 of Trustee

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

  
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 Exhibit B 
 FORM OF 2042 NOTE 
 THIS SECURITY IS A GLOBAL REGISTERED SECURITY WITHIN THE MEANING OF
THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE
REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 ASTRAZENECA PLC 
 4.00% Notes due 2042 

 

					
	No. [001]	 		 	$500,000,000

 CUSIP No. 046353 AG3 
 ISIN No. US046353AG32 
 ASTRAZENECA PLC, a public limited
company incorporated under the laws of England and Wales (herein called the “Issuer”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co.,
or registered assigns, the principal sum of Five Hundred Million Dollars on September 18, 2042 and to pay interest thereon from September 18, 2012 or from the most recent Interest Payment Date (as defined below) to which interest has been
paid or duly provided for, semiannually in arrears on September 18 and March 18 in each year, commencing March 18, 2013 (each, an “Interest Payment Date”), at the rate of 4.00% per annum, until the principal hereof is
paid or made available for payment The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on the Regular Record Date (as defined below) for such interest which shall be the 15th calendar day preceding such Interest Payment Date (whether or not such day is a Business Day (as defined below)), as
the case may be. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a subsequent record date (the “Special Record Date”) for the payment of such defaulted interest to be fixed by the Trustee (which shall not be less than five Business Days prior to the
date of payment of such defaulted interest), notice whereof shall be given to Holders of Securities of this series not less than 15 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Payment of the principal of (and premium, if any) and any such interest on this Security
will be made at the office or agency of the Issuer maintained for that purpose in New York City, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts;
provided, however, that at the option of the Issuer payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for
all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been
executed by the Trustee by manual signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 2 

 IN WITNESS WHEREOF, the Issuer has caused this instrument to be duly executed manually or in
facsimile. 
 Dated: September 18, 2012 

 

			
	ASTRAZENECA PLC
		
	By:	 	 
	 Name:
 Title:
	 	 Simon Lowth
 Interim CEO,
Director

 
			
	
		
	By:	 	 
	 Name:
 Title:
	 	 Adrian Kemp
 Company
Secretary

 This is one of the Securities of the series designated herein and referred to in the
within-mentioned Indenture. 
 Dated: September 18, 2012 

 

			
	 THE BANK OF NEW YORK MELLON
 As Trustee

		
	By:	 	 
		 	

  
 3 

 This Security is one of a duly authorized issue of securities of the Issuer (herein called
the “Securities”), issued and to be issued in one or more series under an Indenture, dated as of April 1, 2004 (herein called the “Indenture” which term shall have the meaning assigned to it in such instrument), among the
Issuer and The Bank of New York Mellon (formerly known as The Bank of New York), as successor Trustee (herein called the “Trustee”, which term includes any other successor trustee under the Indenture) to JPMorgan Chase Bank, and reference
is hereby made to the Indenture and to the Officers’ Certificate delivered pursuant to Section 2.08 of the Indenture with respect to this security for a statement of the respective rights, limitations of rights, duties and immunities
thereunder of the Issuer, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited
in aggregate principal amount to U.S.$1,000,000,000. 
 The Securities of this series are subject to redemption, as a whole or
in part, at any time and from time to time, at the election of the Issuer, upon not less than 30 nor more than 60 days’ notice, at a Redemption Price equal to the greater of (i) 100% of the principal amount of the Securities to be
redeemed, and (ii) as determined by the Quotation Agent (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest accrued as
of the date of redemption) discounted to the date of redemption on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate plus 20 basis points plus, in each of cases (i) and (ii) above, accrued
interest thereon to the date of redemption. 
 “Treasury Rate” means, with respect to any redemption date, the rate
per annum equal to the semiannual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such
redemption date. 
 “Comparable Treasury Issue” means the United States Treasury security selected by the Quotation
Agent as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means, with respect to
any redemption date, (i) the average, as determined by the Quotation Agent, of the Reference Treasury Dealer Quotations for such redemption date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, or (ii) if
the Trustee obtains fewer than three such Reference Treasury Dealer Quotations, the average of all such Quotations. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Issuer. 

  
 4 

 “Reference Treasury Dealer” means (i) each of Goldman, Sachs & Co.,
HSBC Securities (USA) Inc., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC, and their respective successors; provided, however, that if the foregoing shall cease to be a primary U.S. Government securities dealer in New York
City (a “Primary Treasury Dealer”), the Issuer shall substitute therefor another Primary Treasury Dealer; and (ii) any other Primary Treasury Dealer selected by the Issuer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any redemption date, the
average, as determined by the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Trustee by such Reference Treasury Dealer at 5:00
p.m., New York City time, on the third Business Day preceding such redemption date. 
 “Business Day” means any day
which is not, in London, England or New York, New York, or the place of payment of amounts payable in respect of the Notes, a Saturday, a Sunday, a legal holiday or a day on which banking institutions are authorized or obligated by law, regulation
or executive order to close. 
 The Securities may be redeemed at the option of the Issuer, in whole but not in part, upon not
less than 30 nor more than 60 days’ notice given as provided in the Indenture, at any time at a Redemption Price equal to the principal amount thereof plus accrued interest to the date fixed for redemption if (a) as a result of a change in
or any amendment to the laws or any regulations or rulings promulgated thereunder of the jurisdiction in which the Issuer is resident for tax purposes (or of any political subdivision or taxing authority thereof or therein) (or in the case of a
successor Person to the Issuer of the jurisdiction in which such successor Person is organized or any political subdivision or taxing authority thereof or therein) or any change in an application or interpretation of such laws, regulations or
rulings, or any change in an application or interpretation of, or any execution of or amendment to, any treaty or treaties affecting taxation to which the jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or
taxing authority thereof or therein (or such other jurisdiction or political subdivision or taxing authority) is a party, which change, amendment application, interpretation or execution becomes effective on or after September 11, 2012 (or, in
the case of a successor Person to the Issuer, the date on which such successor Person became such pursuant to the applicable provision of the Indenture), the Issuer would be required to pay Additional Amounts, as described below or (b) the
Issuer has been advised by its independent legal adviser that, as a result of any action taken by any taxing authority of, or any action brought in a court of competent jurisdiction in, the jurisdiction in which the Issuer is resident for tax
purposes or any political subdivision thereof (or in the case of a successor Person to the Issuer of the jurisdiction in which such successor Person is organized or any political subdivision thereof) (whether or not such action was taken or brought
with respect to the Issuer), which action is taken or brought on or after September 11, 2012 (or, in the case of a successor Person to the Issuer, the date on which such successor Person became such pursuant to the applicable provision of the
Indenture), the Issuer will be required to pay Additional Amounts, as described below, and the payment of such Additional 

  
 5 

 
Amounts cannot be avoided by the use of any reasonable measures available to the Issuer. Prior to any redemption of such a series of Securities, the Issuer shall provide the Trustee with an
Opinion of Counsel that the conditions precedent to the right of the Issuer to redeem such Securities pursuant to this paragraph have occurred. Such Opinion of Counsel shall be based on the laws in effect on the date of such opinion or to become
effective on or before the next succeeding date for payment of principal or interest. 
 In the event of redemption of this
Security in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness on this Security upon compliance by the Issuer
with certain conditions set forth thereon, which provisions apply to this Security. 
 If an Event of Default with respect to
Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 

If any deduction or withholding for any present or future taxes, levies, duties, assessments, imposts or other governmental charges
whatsoever imposed, assessed, levied or collected by or for the account of the government of any jurisdiction in which the Issuer is resident for tax purposes (or any political subdivision or taxing authority thereof or therein) shall at any time be
required from any amounts to be paid by the Issuer under the Securities, the Issuer (subject to compliance by the Holder of such Securities with any administrative requirements) will pay to the Holder of this Security, such additional amounts
(“Additional Amounts”) as will result in the receipt of such amounts as would have been received by the Holder had no such withholding or deduction been required; provided, however, that the Issuer shall not be required to
make any payment of additional amounts for or on account of: 
 (1) any present or future tax, levy, impost or other
governmental charge which would not have been so imposed, assessed, levied or collected but for the fact that the Holder of the relevant Security (or a fiduciary, settlor, beneficiary, member or shareholder of, or possessor of a power over, such
Holder, if such Holder is an estate, trust, partnership or corporation) is or has been a domiciliary, national or resident of, or engaging or having been engaged in a trade or business or maintaining or having maintained a permanent establishment or
being or having been physically present in, the jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or taxing authority thereof or therein or otherwise having or having had some connection with the jurisdiction
in which the Issuer is resident for tax purposes or any political subdivision or taxing authority thereof or therein other than the holding or ownership of a Security, or the collection of principal of, premium, if any, or interest, if any, on, or
the enforcement of, a Security; 

  
 6 

 (2) any present or future tax, levy, impost or other governmental charge which would not
have been so imposed, assessed, levied or collected but for the fact that, where presentation is required, the relevant Security was presented more than thirty days after the date on which such payment became due or was provided for, whichever is
later; 
 (3) any estate, inheritance, gift, sale, transfer, personal property or similar tax, levy, impost or other
governmental charge; 
 (4) any present or future tax, levy, impost or other governmental charge which is payable in a manner
that does not involve deduction or withholding from payments on or in respect of the relevant Security; 
 (5) any present or
future tax, levy, impost or other governmental charge which would not have been so imposed, assessed, levied or collected but for the failure of the Holder or beneficial owner of the relevant Security to comply with any certification, identification
or other reporting requirements concerning the nationality, residence, identity or connection with any jurisdiction in which the Issuer is resident for tax purposes or any political subdivision or taxing authority thereof or therein, if compliance
is required by treaty or by statute, regulation or administrative practice of such jurisdiction or any such political subdivision or taxing authority thereof or therein as a condition to relief or exemption from such tax, levy, impost or other
governmental charge; 
 (6) any present or future tax, levy, impost or other governmental charge is imposed on a payment to an
individual and is required to be made pursuant to European Council Directive 2003/48/EC or any other European Union Directive implementing the conclusions of the ECOFIN Council meeting of 26-27 November 2000 on the taxation of savings or any
law implementing or complying with, or introduced in order to conform to, such Directive; 
 (7) any present or future tax,
levy, impost or other governmental change which a Holder would have been able to avoid by presenting the relevant debt security to another paying agent in a Member State of the European Union or elsewhere; 

(8) any present or future tax, levy, impost or other governmental change which a Holder would have been able to avoid by authorizing the
paying agent to report information in accordance with the procedure laid down by the relevant tax authority or by producing, in the form requested by the relevant tax authority, a declaration, claim, certificate, document or other evidence
establishing exemption therefrom; 

  
 7 

 (9) any present or future tax, levy, impost or other governmental charge imposed, assessed,
levied or collected in respect of a payment under or with respect to a Security to any Holder of the relevant Security that is a fiduciary, partnership or a person other than the sole beneficial owner of such payment or Security to the extent that
the beneficiary or settlor with respect to the fiduciary, member of that partnership or beneficial owner would not have been entitled to the additional amounts or would not have been subject to such tax, levy, impost or charge, had that beneficiary,
settlor, member or beneficial owner been the actual Holder of such Security; or 
 (10) any combination of items
(1) through (9) above. 
 The foregoing provisions shall apply mutatis mutandis to any withholding or deduction for or on account of
any present or future taxes, assessments or governmental charges of whatever nature of any jurisdiction in which any successor Person to the Issuer is organized, or any political subdivision or taxing authority thereof or therein. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Issuer and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Issuer and the Trustee with the consent of the Holders of a majority in principal amount of the Securities
at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principle amount of the Securities of each series at the time Outstanding, on behalf of the Holders of
all Securities of such series to waive compliance by the Issuer with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is
made upon this Security. 
 As set forth in, and subject to, the provisions of the Indenture, no Holder of any Security of this
series will have any right to institute any proceeding with respect to the Indenture, this Security or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with
respect to the Securities of this series, the Holders of not less than 25% in principal amount of the Outstanding Securities of this series shall have made written request, and offered reasonable indemnity, to the Trustee to institute such
proceeding as trustee, and the Trustee shall not have received from the Holders of a majority in principal of the Outstanding Securities of this series a direction inconsistent with such request and shall have failed to institute such proceeding
within 60 days; provided, however, that such limitations do not apply to a suit instituted by the Holder hereof for the enforcement of payment of the principal (and premium, if any) or any interest on this Security on or after the
respective due dates expressed herein. 

  
 8 

 No reference herein to the Indenture and no provision of this Security or of the Indenture
shall alter or impair the obligation of the Issuer, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed or to convert
this Security as provided in the Indenture. 
 The Securities of this series are issuable only in registered form without
coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 
 No service charge shall be made for
any such registration of transfer or exchange, but the Issuer or the Trustee may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentation of this Security for registration of transfer, the Issuer, the Trustee and any agent of the Issuer or the
Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither of the Issuer nor the Trustee nor any such agent shall be affected by notice to the
contrary. 
 This Security shall be governed by and construed in accordance with the laws of the State of New York.

 Unless otherwise defined herein, all terms used in this Security which are defined in the Indenture shall have the
meanings assigned to them in the Indenture. 

  
 9 

 SCHEDULE OF PRINCIPAL AMOUNT 

The initial principal amount of this Security shall be $500,000,000. The following decreases/increases in the principal amount of this
Security have been made: 
  

																	
	 Date of

Decrease/Increase
	  	 	  	 Decrease in

Principal

Amount
	  	 	  	 Increase in

Principal

Amount
	  	 	  	 Total Principal

Amount

Following such
 Decrease/Increase
	  	 	  	 Notation Made

by or on Behalf
 of Trustee

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

									
	  
	  		  	  
	  		  	  
	  		  	  
	  		  	  

  
 10First Amendment to Loan and Security Agreement

 Exhibit 10.1 
 FIRST AMENDMENT  
 TO LOAN AND SECURITY AGREEMENT 

This First Amendment to Loan and Security Agreement (this “Amendment”) is entered into as of August 30, 2012, by and
between COMERICA BANK (“Bank”) and CARBONITE, INC., a Delaware corporation (“Borrower”). 
 RECITALS

 Borrower and Bank are parties to that certain Loan and Security Agreement dated as of May 11, 2011, as amended,
modified, supplemented, extended or restated from time to time (collectively, the “Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment. 

NOW, THEREFORE, for good and valuable consideration, the receipt of which is hereby acknowledged, the parties agree as follows:

  

	 	1.	Section 6.6 of the Agreement is hereby amended and restated in its entirety to read as follows: 

6.6 Accounts. Borrower shall maintain, and shall cause all of its Subsidiaries to maintain, all of its and their
depository and operating accounts with Bank and all of its and their securities and investment accounts with Bank and Bank Affiliates (subject to control agreements satisfactory to Bank); provided, however, (a) so long as
(i) no Event of Default has occurred that is continuing and (ii) Borrower maintains unencumbered Cash in one or more accounts with Bank or Bank Affiliates in an amount in excess of fifty percent (50%) of the combined value of all of
its deposit, operating, securities and investment accounts (whether maintained with or through Bank or any other Person), Borrower may maintain cash and securities in excess of such amount in those accounts outside of Bank that are identified on the
Schedule, so long as such accounts remain, at all times, subject to Bank’s first priority security interest, pursuant to account control agreements in form and substance satisfactory to Bank, (b) Borrower’s Subsidiaries may maintain
cash and securities in the accounts outside of Bank identified on the Schedule, so long as such accounts (other than accounts of Excluded Foreign Subsidiaries) remain, at all times, subject to Bank’s first priority security interest, pursuant
to account control agreements in form and substance satisfactory to Bank, and (c) Carbonite China may maintain its accounts outside of Bank that are identified on the Schedule and such accounts may be maintained without being subject to an
account control agreement. 
  

	 	2.	Section 6.7 of the Agreement is hereby amended and restated in its entirety to read as follows: 

6.7 Financial Covenants. Borrower shall at all times maintain the following financial and operational ratios and
covenants: 
 (a) Minimum Current Ratio. From and after the date on which the outstanding Obligations are
first equal to or exceed Five Million Dollars ($5,000,000), a ratio of (i) the sum of Borrower’s Cash plus the net billed amount of all Accounts aged less than ninety (90) days from invoice date, to (ii) Current Liabilities
(excluding deferred revenue), of at least 1.25 to 1.00, tested as of the last day of each Reporting Period. 

(b) Minimum Active Subscriptions. From and after the date on which the outstanding Obligations are first equal to
or exceed Five Million Dollars ($5,000,000), not fewer than One Million (1,000,000) subscribers (not Affiliated with Borrower) under active Subscription Agreements, tested as of the last day of each Reporting Period. 

3. Exhibit A to the Agreement is hereby amended by adding, or amending and restating, the following defined terms to read as
follows: 
 “Aggregate Acquisition Cap” means, for any time of determination, Thirty Million Dollars
($30,000,000) if, at such time, the Net Cash Amount, both before and after giving effect to the subject 

  
 -1-

 
Acquisition Transaction, is equal to or greater than Twenty Million Dollars ($20,000,000). In respect of any Acquisition Transaction, the Aggregate Acquisition Cap applicable to such Acquisition
Transaction shall be determined based on the Net Cash Amount calculated both before and after giving effect to the consummation of such Acquisition Transaction. For the sake of clarity, the parties acknowledge and agree that such amounts are not
incremental and that each Acquisition Transaction shall count against the Aggregate Acquisition Cap and all subsequent calculations of the Aggregate Acquisition Cap. 
 “Cash” means unrestricted cash, cash equivalents and marketable securities. 
 “Current Liabilities” means, as of any applicable date, all amounts that should, in accordance with GAAP, be included as current liabilities on the consolidated balance sheet of Borrower and its
Subsidiaries, as at such date, plus, to the extent not already included therein, all Obligations owing to Bank. 
 “First
Amendment Closing Date” means August 30, 2012. 
 “Pricing Addendum” means that certain
Prime Referenced Rate Addendum to Loan and Security Agreement, by and between Bank and Borrower, dated as of the First Amendment Closing Date, as amended, modified, supplemented or restated from time to time, a copy of which is attached hereto as
Exhibit F. 
 “Revolving Line” means a Credit Extension of up to Twenty Five Million Dollars ($25,000,000).

 “Revolving Maturity Date” means August 30, 2013. 

4. Exhibit D to the Agreement is hereby amended and restated in its entirety and replaced with Exhibit D attached hereto.

 5. Exhibit E to the Agreement is hereby amended and restated in its entirety and replaced with Exhibit E
attached hereto. 
 6. Exhibit F to the Agreement is hereby amended and restated in its entirety and replaced with
Exhibit F attached hereto. 
 7. No course of dealing on the part of Bank or its officers, nor any failure or delay in
the exercise of any right by Bank, shall operate as a waiver thereof, and any single or partial exercise of any such right shall not preclude any later exercise of any such right. Bank’s failure at any time to require strict performance by
Borrower of any provision shall not affect any right of Bank thereafter to demand strict compliance and performance. Any suspension or waiver of a right must be in writing signed by an officer of Bank. 

8. Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the Agreement (as amended by this
Amendment). The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery, and
performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing effectiveness of
all promissory notes, guaranties, security agreements, mortgages, deeds of trust, environmental agreements, and all other instruments, documents and agreements entered into in connection with the Agreement. Borrower hereby further affirms its
absolute and unconditional promise to pay to Bank the Advances, all other Credit Extensions and all other amounts due under the Letters of Credit and the other Loan Documents (including, without limitation, the Obligations), at the times and in the
amounts provided for therein. Borrower confirms and agrees that the obligations of Borrower to Bank under the Agreement as supplemented hereby are secured by and entitled to the benefits of the Loan Documents. The parties agree that this Amendment
shall be deemed to be one of the Loan Documents under the Agreement. Nothing in this Amendment shall constitute a satisfaction of any of Borrower’s Obligations. 

  
 -2-

 9. In order to induce Bank to enter into this Amendment, Borrower hereby represents and
warrants to Bank as follows: 
 9.1 The representations and warranties contained in the Agreement and the other Loan Documents
were true and correct in all material respects when made and continue to be true and correct in all material respects as of the date of this Amendment. 
 9.2 Both before and immediately after giving effect to this Amendment and the other transactions contemplated hereby, no Event of Default, or other event or circumstance that with the giving of notice or
the passage of time could become an Event of Default, has occurred and is continuing. 
 9.3 The execution, delivery, and
performance by Borrower of this Amendment and the other documents, instruments and agreements to which Borrower is a party delivered or to be delivered to Bank in connection herewith (i) are within the corporate powers of Borrower and have been
duly authorized by all necessary corporate action on the part of Borrower, (ii) do not require any governmental or third party consents, except those which have been duly obtained and are in full force and effect, (iii) do not and will not
conflict with any requirement of law, Borrower’s or any Guarantor’s articles or certificate of incorporation, bylaws, operating agreement, partnership agreement, minutes or resolutions, (iv) after giving effect to this Amendment, do
not result in any breach of or constitute a default under any agreement or instrument to which Borrower, any Guarantor or any of their respective Subsidiaries is a party or by which they or any of their respective properties are bound, and
(v) do not result in or require the creation or imposition of any mortgage, deed of trust, pledge, lien, security interest or other charge or encumbrance of any nature upon any of the assets or properties of Borrower or any Guarantor, other
than those in favor of Bank. 
 9.4 This Amendment and the other instruments and agreements delivered or to be delivered to Bank
in connection herewith have been duly executed and delivered by Borrower and constitutes the legal, valid, and binding obligation of Borrower, enforceable against Borrower in accordance with their respective terms, except to the extent that
(i) enforcement may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws of general application affecting the rights and remedies of creditors, (ii) enforcement may be subject to general principles of
equity, and (iii) the availability of the remedies of specific performance and injunctive relief may be subject to the discretion of the court before which any proceedings for such remedies may be brought. 

9.5 Borrower does not have any right of offset, defense, counterclaim, dispute or disagreement of any kind or nature whatsoever with
respect to any of its liabilities, obligations or indebtedness arising under or in connection with any Loan Document. 
 10. As
a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance satisfactory to Bank, the following: 
 (a) this Amendment, duly executed by Borrower; 
 (b) an amended and restated
Pricing Addendum, duly executed by Borrower; 
 (c) an Affirmation of Guaranties and Security Agreement, duly executed by each
Guarantor; 
 (d) undated assignments separate from certificate (aka stock powers) duly executed in blank by Borrower with
respect to the shares of stock owned by Borrower in each Guarantor; 
 (e) corporate resolutions and incumbency certifications,
duly executed by Borrower and each Guarantor; 
 (f) a fully-earned and non-refundable amendment fee in the amount of $22,500,
which may be debited from any of Parent’s or any other Borrower’s accounts; 
 (g) an amount equal to all Bank
Expenses incurred through the date of this Amendment, which amounts may be debited from any of Borrower’s accounts with Bank; and 

  
 -3-

 (h) such other documents, instruments and certificates and completion of such other
matters, as Bank may reasonably deem necessary or appropriate. 
 11. This Amendment may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which together shall constitute one instrument. 

[Remainder of Page Left Blank] 

  
 -4-

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above
written. 
  

			
	CARBONITE, INC.
		
	By:	 	/s/ David Friend
	Title:	 	Chief Executive Officer

  

			
	COMERICA BANK
		
	By:	 	/s/ James Demoy
	Title:	 	Vice President

 [Signature Page to First Amendment to Loan and Security Agreement] 

 EXHIBIT D 
 BORROWING BASE CERTIFICATE 
  

					
	Borrower: Carbonite, Inc.	 	Bank:	 	Comerica Bank
		 		 	Technology & Life Sciences Division
	Commitment Amount: $25,000,000	 		 	Loan Analysis Department
		 		 	100 Federal Street
		 		 	28th Floor, MC 5119
		 		 	Boston, MA 02110
		 		 	Phone: (617) 757-6336
		 		 	Fax: (617) 757-6351

  

									
	 CONSUMER SUBSCRIPTION CONTRACT PAYMENTS
	  				  			
			
	 1.      Total Cash Receipts From Credit Card Sales for consumer
Subscription Contracts for 3
months ending                 
	  				  	$	                    	  
		  				  	  
	  
	 
			
	 BUSINESS SUBSCRIPTION CONTRACT ACCOUNTS RECEIVABLE
	  				  			
	 2.      Accounts (for business Subscription Contracts) invoiced during 3 months ending

	  				  	$	            	  
		  				  	  
	  
	 
	 3.      Additions (please explain on reverse)
	  				  	$	            	  
		  				  	  
	  
	 
	 4.      TOTAL ACCOUNTS RECEIVABLE AS OF
                
	  				  	$	            	  
		  				  	  
	  
	 
			
	 BUSINESS SUBSCRIPTION CONTRACT ACCOUNTS DEDUCTIONS (without duplication)
	  				  			
	 5.      Amounts over 90 days
	  	$	            	  	  			
		  	  
	  
	 	  			
	 6.      Credit Balances over 90 days
	  	$	            	  	  			
		  	  
	  
	 	  			
	 7.      Balance of 25% over 90 day
	  	$	            	  	  			
		  	  
	  
	 	  			
	 8.      Concentration limits 25%
	  	$	            	  	  			
		  	  
	  
	 	  			
	 9.      Foreign Accounts
	  	$	            	  	  			
		  	  
	  
	 	  			
	 10.    Governmental Accounts
	  	$	            	  	  			
		  	  
	  
	 	  			
	 11.    Contra Accounts
	  	$	            	  	  			
		  	  
	  
	 	  			
	 12.    Promotion or Demo Accounts
	  	$	            	  	  			
		  	  
	  
	 	  			
	 13.    Intercompany/Employee Accounts
	  	$	            	  	  			
		  	  
	  
	 	  			
	 14.    Other (please explain below)
	  	$	            	  	  			
		  	  
	  
	 	  			
	 15.    TOTAL ACCOUNTS RECEIVABLE DEDUCTIONS
	  				  	$	            	  
		  				  	  
	  
	 
	 16.    Eligible Subscription Contract Accounts (#4 minus #15)
	  				  	$	            	  
		  				  	  
	  
	 
			
	 AVERAGE SUBSCRIPTION RENEWAL RATE
	  				  			
	 17.    Actual renewals during month ending
             (three months prior)
	  				  			
		  	  
	  
	 	  			
	 18.    Scheduled/ Eligible renewals during month ending
             (three months prior)
	  				  			
		  	  
	  
	 	  			
	 19.    Month 3 Renewal Rate (#17 divided by #18)
	  				  			
		  				  	  
	  
	 
	 20.    Actual renewals during month ending
             (two months prior)
	  				  			
		  	  
	  
	 	  			
	 21.    Scheduled/ Eligible renewals during month ending
             (two months prior)
	  				  			
		  	  
	  
	 	  			
	 22.    Month 2 Renewal Rate (#20 divided by #21)
	  				  			
		  				  	  
	  
	 
	 23.    Actual renewals during month ending
             (month ending on Certificate date)
	  				  			
		  	  
	  
	 	  			
	 24.    Scheduled/ Eligible renewals during month ending
             (month ending on Certificate date)
	  				  			
		  	  
	  
	 	  			
	 25.    Month 1 Renewal Rate (#23 divided by #24)
	  				  			
		  				  	  
	  
	 
	 26.    ADVANCE RATE ([#19 plus #22 plus #25] divided by 3]
	  				  			
		  				  	  
	  
	 
			
	 BORROWING BASE
	  				  			
	 27.    Applicable Bookings (#1 plus 16)
	  	$	 	  	  			
		  	  
	  
	 	  			
	 28.    BORROWING BASE (#26 times #27)
	  	$	 	  	  			
		  	  
	  
	 	  			
			
	 BALANCES
	  				  			
	 29.    Maximum Loan Amount
	  	$	25,000,000	  	  			
	 30.    Total Funds Available (Lesser of #28 or #29)
	  				  	$	            	  
		  				  	  
	  
	 
	 31.    Outstanding under Sublimits (if any)
	  				  	$	 	  
		  				  	  
	  
	 
	 32.    Present balance owing on Line of Credit
	  				  	$	 	  
		  				  	  
	  
	 
	 33.    Reserve Position (#30 minus #31 and #32)
	  				  	$	 	  
		  				  	  
	  
	 

 The undersigned represents and warrants that the foregoing is true, complete and correct, and that the information
reflected in this Borrowing Base Certificate complies with the representations and warranties set forth in the Loan and Security Agreement between the undersigned and Comerica Bank. 

 

					
	 Comments:
	 		 	 
	 	 		 	 BANK USE
ONLY
 Rec’d By:
                                         
   
 Date:
                                         
           
 Reviewed By:
                                      

Date:
                                         
           
  

	 CARBONITE, INC.

Authorized Signer
	 		 

  

 EXHIBIT E 
 COMPLIANCE CERTIFICATE 
  

			
	Please send all Required Reporting to:	 	 Comerica Bank

Technology & Life Sciences Division

Loan Analysis Department
 250 Lytton
Avenue
 3rd Floor, Mail Code 4240
 Palo
Alto, California 94301
 Phone: 650-462-6060
 Fax: 650-462-6061

 FROM: CARBONITE, INC. 
 The undersigned authorized Officer of CARBONITE, INC., a Delaware corporation (“Borrower”), hereby certifies that in accordance with the terms and conditions of the Loan and Security Agreement
between Borrower and Bank (the “Agreement”), (i)Borrower is in complete compliance for the period ending
                                         
                        with all required covenants, including without limitation the ongoing registration of intellectual property
rights in accordance with Section 6.8, except as noted below and (ii) all representations and warranties of Borrower stated in the Agreement are true and correct in all material respects as of the date hereof (provided, however, that those
representations and warranties expressly referring to another date remain true, correct and complete in all material respects as of such date). Attached herewith are the required documents supporting the above certification. The Officer further
certifies that these are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying letter or footnotes. 

Please indicate compliance status by circling Yes/No under “Complies” or “Applicable” column. 

 

													
	REPORTING COVENANTS	  	REQUIRED	  	COMPLIES	 
				
	 Company Prepared Monthly F/S
	  	Monthly*, within 25 days	  	 	YES	  	  	 	NO	  
	 Compliance Certificate
	  	Monthly*, within 25 days	  	 	YES	  	  	 	NO	  
	 CPA Audited, Unqualified F/S
	  	Annually, within 180 days of FYE	  	 	YES	  	  	 	NO	  
	 Borrowing Base Cert., A/R & A/P Agings
	  	Monthly*, within 25 days	  	 	YES	  	  	 	NO	  
	 Detailed Schedules re Applicable Bookings, Subscription Renewal Rate and Advance Rate calculations
	  	Monthly, within 25 days	  	 	YES	  	  	 	NO	  
	 Annual Business Plan (incl. operating budget)
	  	Annually, within 30 days of FYE	  	 	YES	  	  	 	NO	  
	 IP Report
	  	Quarterly	  	 	YES	  	  	 	NO	  
	 Audit
	  	Semi-annual	  	 	YES	  	  	 	NO	  
				
	 If Public:
	  		  				  			
	 10-Q
	  	Quarterly, within 5 days of SEC filing (50 days)	  	 	YES	  	  	 	NO	  
	 10-K
	  	Annually, within 5 days of SEC filing (95 days)	  	 	YES	  	  	 	NO	  
				
		  	* Quarterly if no outstanding Advances w/in past 30 days	  				  			
					
		  	REQUIRED	  	ACTUAL	  				  			
	 Net Cash Amount
	  	n/a	  	$                            
        	  	 	—  	  	  	 	—  	  
	 Total amount of Borrower’s cash and
	  	n/a	  	$                             
   **	  	 	YES	  	  	 	NO	  
	 investments
	  		  				  			
	 Total amount of Borrower’s cash and
	  	> 50% of all accounts **	  	$                             
       	  	 	YES	  	  	 	NO	  
	 investments maintained with Bank
	  	**Cash/investments outside of Bank must be less than 50% of all cash and investments	   

  

											
	 REPORTING COVENANTS
	  	DESCRIPTION	  	APPLICABLE	 
				
	 Legal Action > $500,000 (Sect. 6.2(a)(iv))
	  	Notify promptly upon notice
                        	  	 	YES	  	  	 	NO	  
	 Inventory Disputes > $250,000 (Sect. 6.3)
	  	Notify promptly upon notice
                        	  	 	YES	  	  	 	NO	  
	 Cross default with other agreements
	  	Notify promptly upon notice
                        	  	 	YES	  	  	 	NO	  
	 > $500,000 (Sect. 8.7)
	  		  	 	YES	  	  	 	NO	  
	 Judgment > $500,000 (Sect. 8.9)
	  	Notify promptly upon notice
                        	  	 	YES	  	  	 	NO	  
	 Highest outstanding balance under Revolving Line prior to date of Certificate
	  	$                            
***/****	  	 	N/A	  	  	 	N/A	  

															
				
	 FINANCIAL COVENANTS
	  	 	REQUIRED	  	 	ACTUAL	  	 	COMPLIES	  
			
	 TESTED MONTHLY (QUARTERLY IF NO OUTSTANDINGS):
	  				  			
					
	 Minimum Current Ratio***
	  	 
 	> 1.25 to
1.00	  
  	 	            to 1.00	  	 	YES	  	  	 	NO	  
	 Minimum Subscribers****
	  	 	> 1,000,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
				
	 OTHER COVENANTS
	  	 	REQUIRED	  	 	ACTUAL	  	 	COMPLIES	  
					
	 Permitted Acquisitions
	  	 	<$30 million*****	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Indebtedness for equipment leases
	  	 	<$250,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Investments for stock repurchase
	  	 	<$250,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Investments in Subsidiaries
	  	 	<$100,000******	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Investments for employee loans
	  	 	<$250,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Investments for joint ventures
	  	 	<$100,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Liens for equipment leases
	  	 	<$250,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			
	 Permitted Transfers
	  	 	<$250,000	  	 		  	 	YES	  	  	 	NO	  
		  				 	  
	  				  			

  

	***	Applicable at all times after date Revolving Line outstandings are first equal to or exceed $5 million 

	****	Applicable at all times after date Revolving Line outstandings are first equal to or exceed $5 million 

	*****	$30 million if Net Cash Amount >$20 million; otherwise $0 

	******	$2 million (less Investment in ICP license entity) in Carbonite China if Net Cash Amount < $15 million; $5 million (less Investment in ICP license entity) in
Carbonite China if Net Cash Amount > $15 million 

 Please Enter Below Comments Regarding Violations: 

The Officer further acknowledges that at any time Borrower is not in compliance with all the terms set forth in the Agreement, including, without
limitation, the financial covenants, no credit extensions will be made. 
 Very truly yours, 

 

			
	 
	Authorized Signer
	
	Name:
	
	Title:

 EXHIBIT F 
 PRIME REFERENCED RATE ADDENDUM 

 PRIME REFERENCED RATE ADDENDUM TO 

LOAN AND SECURITY AGREEMENT 
 This Prime Referenced Rate Addendum to Loan and Security Agreement (this “Addendum”) is entered into as of August 30, 2012, by and between Comerica Bank (“Bank”) and Carbonite,
Inc., a Delaware corporation (“Borrower”). This Addendum: (a) supplements the terms of the Loan and Security Agreement dated as of May 11, 2011 by and between Borrower and Bank (as the same may be amended, modified, supplemented,
extended or restated from time to time, collectively, the “Agreement”); and (b) amends and restates, in its entirety, but without novation, the Prime Referenced Rate Addendum to Loan and Security Agreement dated as of May 11,
2011 by and between Borrower and Bank. 
 1. Definitions. As used in this Addendum, the following terms shall have the following
meanings. Initially capitalized terms used and not defined in this Addendum shall have the meanings ascribed thereto in the Agreement. 
 a. “Applicable Margin” means one quarter of one percent (0.25%) per annum. 
 b. “Business Day” means any day, other than a Saturday, Sunday or any other day designated as a holiday under Federal or applicable State statute or regulation, on which Bank is open for all or
substantially all of its domestic and international business (including dealings in foreign exchange) in San Jose, California, and, in respect of notices and determinations relating to the Daily Adjusting LIBOR Rate, also a day on which dealings in
dollar deposits are also carried on the London interbank market and on which banks are open for business in London, England. 

c. “Change in Law” means the occurrence, after the date hereof, of any of the following: (i) the adoption or introduction
of, or any change in any applicable law, treaty, rule or regulation (whether domestic or foreign) now or hereafter in effect and whether or not applicable to Bank on such date, or (ii) any change in interpretation, administration or
implementation thereof of any such law, treaty, rule or regulation by any Governmental Authority, or (iii) the issuance, making or implementation by any Governmental Authority of any interpretation, administration, request, regulation,
guideline, or directive (whether or not having the force of law), including any risk-based capital guidelines. For purposes of this definition, (x) a change in law, treaty, rule, regulation, interpretation, administration or implementation
shall include, without limitation, any change made or which becomes effective on the basis of a law, treaty, rule, regulation, interpretation administration or implementation then in force, the effective date of which change is delayed by the terms
of such law, treaty, rule, regulation, interpretation, administration or implementation, and (y) the Dodd-Frank Wall Street Reform and Consumer Protection Act (Pub. L. 111-203, H.R. 4173) and all requests, rules, regulations, guidelines,
interpretations or directives promulgated thereunder or issued in connection therewith shall be deemed to be a “Change in Law”, regardless of the date enacted, adopted, issued or promulgated, whether before or after the date hereof, and
(z) all requests, rules, guidelines or directives promulgated by the Bank for International Settlements, the Basel Committee on Banking Supervision (or any successor or similar authority) or the United States regulatory authorities, in each
case pursuant to Basel III, shall each be deemed to be a “Change in Law”, regardless of the date enacted, adopted, issued or implemented. 
 d. “Daily Adjusting LIBOR Rate” means, for any day, a per annum interest rate which is equal to the quotient of the following: 

 

	 	(1)	 for any day, the per annum rate of interest determined on the basis of the rate for deposits in United States Dollars for a period equal to one
(1) month appearing on Page BBAM of the Bloomberg Financial Markets Information Service as of 8:00 a.m. (California time) (or as soon thereafter as practical) on such day, or if such day is not a Business Day, on the immediately preceding
Business Day. In the event that such rate does not appear on Page BBAM of the Bloomberg Financial Markets Information Service (or otherwise on such Service) on any day, the “Daily Adjusting LIBOR Rate” for such day shall be determined by
reference to such other publicly available service for displaying eurodollar rates as may be reasonably selected by Bank, or in the absence of such other service, the “Daily Adjusting LIBOR Rate” for such day shall, instead, be determined
based upon the average of the rates at which Bank is offered dollar deposits at or about 8:00 a.m. 

  
 -1-

	 	
(California time) (or as soon thereafter as practical), on such day, or if such day is not a Business Day, on the immediately preceding Business Day, in the interbank eurodollar market in an
amount comparable to the outstanding principal amount of the Obligations and for a period equal to one (1) month; 

  

	 	    	divided by 

  

	 	(2)	1.00 minus the maximum rate (expressed as a decimal) on such day at which Bank is required to maintain reserves on “Euro-currency Liabilities” as defined in
and pursuant to Regulation D of the Board of Governors of the Federal Reserve System or, if such regulation or definition is modified, and as long as Bank is required to maintain reserves against a category of liabilities which includes eurodollar
deposits or includes a category of assets which includes eurodollar loans, the rate at which such reserves are required to be maintained on such category. 

 e. “Governmental Authority” means the government of the United States of America or any other nation, or of any political subdivision thereof, whether state or local, and any agency, authority,
instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to government (including, without limitation, any
supranational bodies such as the European Union or the European Central Bank). 
 f. “LIBOR Lending Office” means
Bank’s office located in the Cayman Islands, British West Indies, or such other branch of Bank, domestic or foreign, as it may hereafter designate as its LIBOR Lending Office by notice to Borrower. 

g. “Prime Rate” means the per annum interest rate established by Bank as its prime rate for its borrowers, as such rate may vary
from time to time, which rate is not necessarily the lowest rate on loans made by Bank at any such time. 
 h. “Prime
Referenced Rate” means, for any day, a per annum interest rate which is equal to the Prime Rate in effect on such day, but in no event and at no time shall the Prime Referenced Rate be less than the sum of the Daily Adjusting LIBOR Rate for
such day plus two and one-half percent (2.50%) per annum. If, at any time, Bank determines that it is unable to determine or ascertain the Daily Adjusting LIBOR Rate for any day, the Prime Referenced Rate for each such day shall be the Prime
Rate in effect at such time, but not less than two and one-half percent (2.50%) per annum. 
 2. Interest Rate. Subject to the terms
and conditions of this Addendum, the Obligations under the Agreement shall bear interest at the Prime Referenced Rate plus the Applicable Margin. 
 3. Payment of Interest. Accrued and unpaid interest on the unpaid balance of the Obligations outstanding under the Agreement shall be payable monthly, in arrears, on the first day of each month,
until maturity (whether as stated herein, by acceleration, or otherwise). In the event that any payment under this Addendum becomes due and payable on any day which is not a Business Day, the due date thereof shall be extended to the next succeeding
Business Day, and, to the extent applicable, interest shall continue to accrue and be payable thereon during such extension at the rates set forth in this Addendum. Interest accruing hereunder shall be computed on the basis of a year of 360 days,
and shall be assessed for the actual number of days elapsed, and in such computation, effect shall be given to any change in the applicable interest rate as a result of any change in the Prime Referenced Rate on the date of each such change.

 4. Bank’s Records. The amount and date of each advance under the Agreement, its applicable interest rate, and the amount and date
of any repayment shall be noted on Bank’s records, which records shall be conclusive evidence thereof, absent manifest error; provided, however, any failure by Bank to make any such notation, or any error in any such notation,
shall not relieve Borrower of its obligations to repay Bank all amounts payable by Borrower to Bank under or pursuant to this Addendum and the Agreement, when due in accordance with the terms hereof. 

  
 -2-

 5. Default Interest Rate. From and after the occurrence of any Event of Default, and for so long as
any such Event of Default remains unremedied or uncured thereafter, the Obligations outstanding under the Agreement shall bear interest at a per annum rate of five percent (5%) above the otherwise applicable interest rate hereunder, which
interest shall be payable upon demand. In addition to the foregoing, a late payment charge equal to five percent (5%) of each late payment hereunder may be charged on any payment not received by Bank within ten (10) calendar days after the
payment due date therefor, but acceptance of payment of any such charge shall not constitute a waiver of any Event of Default under the Agreement. In no event shall the interest payable under this Addendum and the Agreement at any time exceed the
maximum rate permitted by law. 
 6. Prepayment. Borrower may prepay all or part of the outstanding balance of any Obligations at any
time without premium or penalty. Any prepayment hereunder shall also be accompanied by the payment of all accrued and unpaid interest on the amount so prepaid. Borrower hereby acknowledges and agrees that the foregoing shall not, in any way
whatsoever, limit, restrict, or otherwise affect Bank’s right to make demand for payment of all or any part of the Obligations under the Agreement due on a demand basis in Bank’s sole and absolute discretion. 

7. Regulatory Developments or Other Circumstances Relating to the Daily Adjusting LIBOR Rate. 

a. If any Change in Law shall: (a) subject Bank to any tax, duty or other charge with respect to this Addendum or any Obligations
under the Agreement, or shall change the basis of taxation of payments to Bank of the principal of or interest under this Addendum or any other amounts due under this Addendum in respect thereof (except for changes in the rate of tax on the overall
net income of Bank or its LIBOR Lending Office imposed by the jurisdiction in which Bank’s principal executive office or LIBOR Lending Office is located); or (b) impose, modify or deem applicable any reserve (including, without limitation,
any imposed by the Board of Governors of the Federal Reserve System), special deposit or similar requirement against assets of, deposits with or for the account of, or credit extended by Bank, or shall impose on Bank or the foreign exchange and
interbank markets any other condition affecting this Addendum or the Obligations; and the result of any of the foregoing is to increase the cost to Bank of maintaining any part of the Obligations or to reduce the amount of any sum received or
receivable by Bank under this Addendum by an amount deemed by Bank to be material, then Borrower shall pay to Bank, within fifteen (15) days of Borrower’s receipt of written notice from Bank demanding such compensation, such additional
amount or amounts as will compensate Bank for such increased cost or reduction. A certificate of Bank, prepared in good faith and in reasonable detail by Bank and submitted by Bank to Borrower, setting forth the basis for determining such additional
amount or amounts necessary to compensate Bank shall be conclusive and binding for all purposes, absent manifest error. 
 b. In
the event that any Change in Law affects or would affect the amount of capital required or expected to be maintained by Bank (or any corporation controlling Bank), and Bank determines that the amount of such capital is increased by or based upon the
existence of any obligations of Bank hereunder or the maintaining of any Obligations, and such increase has the effect of reducing the rate of return on Bank’s (or such controlling corporation’s) capital as a consequence of such
obligations or the maintaining of such Obligations to a level below that which Bank (or such controlling corporation) could have achieved but for such circumstances (taking into consideration its policies with respect to capital adequacy), then
Borrower shall pay to Bank, within fifteen (15) days of Borrower’s receipt of written notice from Bank demanding such compensation, additional amounts as are sufficient to compensate Bank (or such controlling corporation) for any increase
in the amount of capital and reduced rate of return which Bank reasonably determines to be allocable to the existence of any obligations of the Bank hereunder or to maintaining any Obligations. A certificate of Bank as to the amount of such
compensation, prepared in good faith and in reasonable detail by Bank and submitted by Bank to the undersigned, shall be conclusive and binding for all purposes absent manifest error. 
 8. Legal Effect. Except as specifically modified hereby, all of the terms and conditions of the Agreement remain in full force and effect. 
 9. Conflicts. As to the matters specifically the subject of this Addendum, in the event of any conflict between this Addendum and the Agreement, the terms of this Addendum shall control.

 [Remainder of page left blank] 

  
 -3-

 IN WITNESS WHEREOF, the parties have agreed to the foregoing as of the date first set forth
above. 
  

									
	COMERICA BANK	 		 	CARBONITE, INC.
					
	By:	 	/s/ James Demoy	 		 	By:	 	/s/ David Friend
	Name:  	 	James Demoy	 		 	Name:  	 	David Friend
	Title:    	 	Vice President	 		 	Title:    	 	Chief Executive Officer

 [Signature Page to Prime Referenced Rate Addendum to Loan and Security Agreement]

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