Document:

Indenture

 Exhibit 4.1 

 
  
 InterMune, Inc. 
  

 
 INDENTURE

 Dated as of September 19, 2011 
  

 
 The Bank of New
York Mellon Trust Company, N.A. 
 Trustee 
  

 

 TABLE OF CONTENTS 

 

							
	 	  	Page	 
		
	ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE	  	 	1	  
	 Section 1.1.
	  	Definitions	  	 	1	  
	 Section 1.2.
	  	Other Definitions	  	 	4	  
	 Section 1.3.
	  	Incorporation by Reference of Trust Indenture Act	  	 	5	  
	 Section 1.4.
	  	Rules of Construction	  	 	5	  
		
	ARTICLE II. THE SECURITIES	  	 	6	  
	 Section 2.1.
	  	Issuable in Series	  	 	6	  
	 Section 2.2.
	  	Establishment of Terms of Series of Securities	  	 	6	  
	 Section 2.3.
	  	Execution and Authentication	  	 	8	  
	 Section 2.4.
	  	Registrar and Paying Agent	  	 	9	  
	 Section 2.5.
	  	Paying Agent to Hold Money in Trust	  	 	10	  
	 Section 2.6.
	  	Securityholder Lists	  	 	10	  
	 Section 2.7.
	  	Transfer and Exchange	  	 	10	  
	 Section 2.8.
	  	Mutilated, Destroyed, Lost and Stolen Securities	  	 	11	  
	 Section 2.9.
	  	Outstanding Securities	  	 	12	  
	 Section 2.10.
	  	Treasury Securities	  	 	12	  
	 Section 2.11.
	  	Temporary Securities	  	 	13	  
	 Section 2.12.
	  	Cancellation	  	 	13	  
	 Section 2.13.
	  	Defaulted Interest	  	 	13	  
	 Section 2.14.
	  	Global Securities	  	 	13	  
	 Section 2.15.
	  	CUSIP Numbers	  	 	14	  
		
	ARTICLE III. REDEMPTION	  	 	15	  
	 Section 3.1.
	  	Notice to Trustee	  	 	15	  
	 Section 3.2.
	  	Selection of Securities to be Redeemed	  	 	15	  
	 Section 3.3.
	  	Notice of Redemption	  	 	15	  
	 Section 3.4.
	  	Effect of Notice of Redemption	  	 	16	  
	 Section 3.5.
	  	Deposit of Redemption Price	  	 	16	  
	 Section 3.6.
	  	Securities Redeemed in Part	  	 	16	  
		
	ARTICLE IV. COVENANTS	  	 	17	  
	 Section 4.1.
	  	Payment of Principal and Interest	  	 	17	  
	 Section 4.2.
	  	SEC Reports	  	 	17	  
	 Section 4.3.
	  	Compliance Certificate	  	 	17	  
	 Section 4.4.
	  	Stay, Extension and Usury Laws	  	 	18	  
	 Section 4.5.
	  	Corporate Existence	  	 	18	  
		
	ARTICLE V. SUCCESSORS	  	 	18	  
	 Section 5.1.
	  	When Company May Merge, Etc.	  	 	18	  
	 Section 5.2.
	  	Successor Corporation Substituted	  	 	19	  

  
 i 

							
	ARTICLE VI. DEFAULTS AND REMEDIES	  	 	19	  
	 Section 6.1.
	  	Events of Default	  	 	19	  
	 Section 6.2.
	  	Acceleration of Maturity; Rescission and Annulment	  	 	20	  
	 Section 6.3.
	  	Collection of Indebtedness and Suits for Enforcement by Trustee	  	 	21	  
	 Section 6.4.
	  	Trustee May File Proofs of Claim	  	 	22	  
	 Section 6.5.
	  	Trustee May Enforce Claims Without Possession of Securities	  	 	22	  
	 Section 6.6.
	  	Application of Money Collected	  	 	22	  
	 Section 6.7.
	  	Limitation on Suits	  	 	23	  
	 Section 6.8.
	  	Unconditional Right of Holders to Receive Principal and Interest	  	 	23	  
	 Section 6.9.
	  	Restoration of Rights and Remedies	  	 	24	  
	 Section 6.10.
	  	Rights and Remedies Cumulative	  	 	24	  
	 Section 6.11.
	  	Delay or Omission Not Waiver	  	 	24	  
	 Section 6.12.
	  	Control by Holders	  	 	24	  
	 Section 6.13.
	  	Waiver of Past Defaults	  	 	25	  
	 Section 6.14.
	  	Undertaking for Costs	  	 	25	  
		
	ARTICLE VII. TRUSTEE	  	 	25	  
	 Section 7.1.
	  	Duties of Trustee	  	 	25	  
	 Section 7.2.
	  	Rights of Trustee	  	 	27	  
	 Section 7.3.
	  	Individual Rights of Trustee	  	 	28	  
	 Section 7.4.
	  	Trustee’s Disclaimer	  	 	28	  
	 Section 7.5.
	  	Notice of Defaults	  	 	28	  
	 Section 7.6.
	  	Reports by Trustee to Holders	  	 	29	  
	 Section 7.7.
	  	Compensation and Indemnity	  	 	29	  
	 Section 7.8.
	  	Replacement of Trustee	  	 	30	  
	 Section 7.9.
	  	Successor Trustee by Merger, Etc.	  	 	31	  
	 Section 7.10.
	  	Eligibility; Disqualification	  	 	31	  
	 Section 7.11.
	  	Preferential Collection of Claims Against Company	  	 	31	  
		
	ARTICLE VIII. SATISFACTION AND DISCHARGE; DEFEASANCE	  	 	31	  
	 Section 8.1.
	  	Satisfaction and Discharge of Indenture	  	 	31	  
	 Section 8.2.
	  	Application of Trust Funds; Indemnification	  	 	32	  
	 Section 8.3.
	  	Legal Defeasance of Securities of any Series	  	 	33	  
	 Section 8.4.
	  	Covenant Defeasance	  	 	34	  
	 Section 8.5.
	  	Repayment to Company	  	 	35	  
	 Section 8.6.
	  	Reinstatement	  	 	36	  
		
	ARTICLE IX. AMENDMENTS AND WAIVERS	  	 	36	  
	 Section 9.1.
	  	Without Consent of Holders	  	 	36	  
	 Section 9.2.
	  	With Consent of Holders	  	 	36	  
	 Section 9.3.
	  	Limitations	  	 	37	  
	 Section 9.4.
	  	Compliance with Trust Indenture Act	  	 	38	  
	 Section 9.5.
	  	Revocation and Effect of Consents	  	 	38	  
	 Section 9.6.
	  	Notation on or Exchange of Securities	  	 	38	  
	 Section 9.7.
	  	Trustee Protected	  	 	38	  

  
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	ARTICLE X. MISCELLANEOUS	  	 	38	  
	 Section 10.1.
	  	Trust Indenture Act Controls	  	 	38	  
	 Section 10.2.
	  	Notices	  	 	39	  
	 Section 10.3.
	  	Communication by Holders with Other Holders	  	 	40	  
	 Section 10.4.
	  	Certificate and Opinion as to Conditions Precedent	  	 	40	  
	 Section 10.5.
	  	Statements Required in Certificate or Opinion	  	 	40	  
	 Section 10.6.
	  	Rules by Trustee and Agents	  	 	41	  
	 Section 10.7.
	  	Legal Holidays	  	 	41	  
	 Section 10.8.
	  	No Recourse Against Others	  	 	41	  
	 Section 10.9.
	  	Counterparts	  	 	41	  
	 Section 10.10.
	  	Governing Laws	  	 	41	  
	 Section 10.11.
	  	No Adverse Interpretation of Other Agreements	  	 	41	  
	 Section 10.12.
	  	Successors	  	 	42	  
	 Section 10.13.
	  	Severability	  	 	42	  
	 Section 10.14.
	  	Table of Contents, Headings, Etc.	  	 	42	  
	 Section 10.15.
	  	Securities in a Foreign Currency or in ECU	  	 	42	  
	 Section 10.16.
	  	Judgment Currency	  	 	43	  
	 Section 10.17.
	  	Force Majeure	  	 	43	  
	 Section 10.18.
	  	Waiver of Jury Trial	  	 	44	  
		
	ARTICLE XI. SINKING FUNDS	  	 	44	  
	 Section 11.1.
	  	Applicability of Article	  	 	44	  
	 Section 11.2.
	  	Satisfaction of Sinking Fund Payments with Securities	  	 	44	  
	 Section 11.3.
	  	Redemption of Securities for Sinking Fund	  	 	45	  

  
 iii

 INTERMUNE, INC. 

Reconciliation and tie between Trust Indenture Act of 1939 and 
 Indenture, dated as of September 19, 2011 
  

					
	§ 310(a)(1)	 		  	7.10
	(a)(2)	 		  	7.10
	(a)(3)	 		  	Not Applicable
	(a)(4)	 		  	Not Applicable
	(a)(5)	 		  	7.10
	(b)	 		  	7.10
	§ 311(a)	 		  	7.11
	(b)	 		  	7.11
	(c)	 		  	Not Applicable
	§ 312(a)	 		  	2.6
	(b)	 		  	10.3
	(c)	 		  	10.3
	§ 313(a)	 		  	7.6
	(b)(1)	 		  	7.6
	(b)(2)	 		  	7.6
	(c)(1)	 		  	7.6
	(d)	 		  	7.6
	§ 314(a)	 		  	4.2, 10.5
	(b)	 		  	Not Applicable
	(c)(1)	 		  	10.4
	(c)(2)	 		  	10.4
	(c)(3)	 		  	Not Applicable
	(d)	 		  	Not Applicable
	(e)	 		  	10.5
	(f)	 		  	Not Applicable
	§ 315(a)	 		  	7.1
	(b)	 		  	7.5
	(c)	 		  	7.1
	(d)	 		  	7.1
	(e)	 		  	6.14
	§ 316(a)	 		  	2.10
	(a)(1)(A)	 		  	6.12
	(a)(1)(B)	 		  	6.13
	(b)	 		  	6.8
	§ 317(a)(1)	 		  	6.3
	(a)(2)	 		  	6.4
	(b)	 		  	2.5
	§ 318(a)	 		  	10.1

  
 Note:
This reconciliation and tie shall not, for any purpose, be deemed to be part of the Indenture. 

  
 iv 

 Indenture dated as of September 19, 2011 between InterMune, Inc., a company
incorporated under the laws of Delaware (“Company”), and The Bank of New York Mellon Trust Company, N.A., a national banking association (“Trustee”). 

Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders of
the Securities issued under this Indenture. 
 ARTICLE I. 
 DEFINITIONS AND INCORPORATION BY REFERENCE 

Section 1.1. Definitions. 

“Additional Amounts” means any additional amounts which are required hereby or by any Security, under
circumstances specified herein or therein, to be paid by the Company in respect of certain taxes imposed on Holders specified herein or therein and which are owing to such Holders. 

“Affiliate” of any specified person means any other person directly or indirectly controlling or
controlled by or under common control with such specified person. For the purposes of this definition, “control” (including, with correlative meanings, the terms “controlled by” and “under common control with”), as used
with respect to any person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through the ownership of voting securities or by agreement or
otherwise. 
 “Agent” means any Registrar, Paying Agent or Notice Agent. 

“Board of Directors” means the board of directors of the Company or any duly authorized committee
thereof. 
 “Board Resolution” means a copy of a resolution certified by the Secretary or an
Assistant Secretary of the Company to have been adopted by the Board of Directors or pursuant to authorization by the Board of Directors and to be in full force and effect on the date of the certificate and delivered to the Trustee. 

“Business Day” means, unless otherwise provided by Board Resolution, Officer’s Certificate or
supplemental indenture hereto for a particular Series, any day except a Saturday, Sunday or a legal holiday in The City of New York (or in connection with any payment, the place of payment) on which banking institutions are authorized or required by
law, regulation or executive order to close. 
 “Capital Stock” means any and all shares,
interests, participations, rights or other equivalents (however designated) of corporate stock. 

“Company” means the party named as such above until a successor replaces it and thereafter means the
successor. 

 “Company Order” means a written order signed in the name of
the Company by an Officer. 
 “Corporate Trust Office” means the office of the Trustee at which
at any particular time its corporate trust business related to this Indenture shall be principally administered, which office at the dated hereof is located at 700 South Flower Street, Suite 500, Los Angeles, California 90017, Attention: Corporate
Trust Unit, or such other address as the Trustee may designate from time to time by notice to the Holders and the Company, or the principal corporate trust office of any successor Trustee (or such other address as such successor Trustee may
designate from time to time by notice to the Holders and the Company). 
 “Default” means any
event which is, or after notice or passage of time or both would be, an Event of Default. 

“Depositary” means, with respect to the Securities of any Series issuable or issued in whole or in part
in the form of one or more Global Securities, the person designated as Depositary for such Series by the Company, which Depositary shall be a clearing agency registered under the Exchange Act; and if at any time there is more than one such person,
“Depositary” as used with respect to the Securities of any Series shall mean the Depositary with respect to the Securities of such Series. 
 “Discount Security” means any Security that provides for an amount less than the stated principal amount thereof to be due and payable upon declaration of acceleration of the maturity
thereof pursuant to Section 6.2. 
 “Dollars” and “$” means the currency
of The United States of America. 
 “Exchange Act” means the Securities Exchange Act of 1934,
as amended. 
 “Foreign Currency” means any currency or currency unit issued by a government
other than the government of The United States of America. 
 “Foreign Government Obligations”
means, with respect to Securities of any Series that are denominated in a Foreign Currency, (i) direct obligations of the government that issued or caused to be issued such currency for the payment of which obligations its full faith and credit
is pledged or (ii) obligations of a person controlled or supervised by or acting as an agency or instrumentality of such government the timely payment of which is unconditionally guaranteed as a full faith and credit obligation by such
government, which, in either case under clauses (i) or (ii), are not callable or redeemable at the option of the issuer thereof. 
 “GAAP” means accounting principles generally accepted in the United States of America set forth in the opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other entity as have been approved by a significant segment of the accounting profession,
which are in effect as of the date of determination. 

  
 2 

 “Global Security” or “Global Securities”
means a Security or Securities, as the case may be, in the form established pursuant to Section 2.2 evidencing all or part of a Series of Securities, issued to the Depositary for such Series or its nominee, and registered in the name of such
Depositary or nominee. 
 “Holder” or “Securityholder” means a person in whose
name a Security is registered. 
 “Indenture” means this Indenture as amended or supplemented
from time to time and shall include the form and terms of particular Series of Securities established as contemplated hereunder. 
 “interest” with respect to any Discount Security which by its terms bears interest only after Maturity, means interest payable after Maturity. 

“Maturity,” when used with respect to any Security, means the date on which the principal of such
Security becomes due and payable as therein or herein provided, whether at the Stated Maturity or by declaration of acceleration, call for redemption or otherwise. 

“Officer” means the Chief Executive Officer, President, the Chief Financial Officer, the Treasurer, the
Secretary, any Assistant Treasurer, any Assistant Secretary or any Vice President of the Company. 

“Officer’s Certificate” means a certificate signed by any Officer. 

“Opinion of Counsel” means a written opinion acceptable to the Trustee. The opinion must be written by
legal counsel who may be an employee of or counsel to the Company. 
 “person” means any
individual, corporation, partnership, joint venture, association, limited liability company, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof. 

“principal” of a Security means the principal of the Security plus, when appropriate, the premium, if
any, on, and any Additional Amounts in respect of, the Security. 
 “Responsible Officer”
means, when used with respect to the Trustee, any officer within the corporate trust department of the Trustee, including any vice president, assistant secretary, senior associate, associate, trust officer or any other officer of the Trustee who
customarily performs functions similar to those performed by the Persons who at the time shall be such officers, respectively, or to whom any corporate trust matter is referred because of such person’s knowledge of and familiarity with the
particular subject and who shall have direct responsibility for the administration of this Indenture. 

“SEC” means the Securities and Exchange Commission. 

“Securities” means the debentures, notes or other debt instruments of the Company of any Series
authenticated and delivered under this Indenture. 

  
 3 

 “Series” or “Series of Securities” means
each series of debentures, notes or other debt instruments of the Company created pursuant to Sections 2.1 and 2.2 hereof. 
 “Stated Maturity” when used with respect to any Security, means the date specified in such Security as the fixed date on which the principal of such Security or interest is due and
payable. 
 “Subsidiary” of any specified person means any corporation, association or other
business entity of which more than 50% of the total voting power of shares of Capital Stock entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers or trustees thereof is at the time owned or
controlled, directly or indirectly, by such person or one or more of the other Subsidiaries of that person or a combination thereof. 
 “TIA” means the Trust Indenture Act of 1939 (15 U.S. Code §§ 77aaa-77bbbb) as in effect on the date of this Indenture; provided, however, that in the event the
Trust Indenture Act of 1939 is amended after such date, “TIA” means, to the extent required by any such amendment, the Trust Indenture Act as so amended. 

“Trustee” means the person named as the “Trustee” in the first paragraph of this instrument
until a successor Trustee shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean or include each person who is then a Trustee hereunder, and if at any time there is more than one
such person, “Trustee” as used with respect to the Securities of any Series shall mean the Trustee with respect to Securities of that Series. 
 “U.S. Government Obligations” means securities which are (i) direct obligations of The United States of America for the payment of which its full faith and credit is pledged or
(ii) obligations of a person controlled or supervised by and acting as an agency or instrumentality of The United States of America the payment of which is unconditionally guaranteed as a full faith and credit obligation by The United States of
America, and which in the case of (i) and (ii) are not callable or redeemable at the option of the issuer thereof, and shall also include a depository receipt issued by a bank or trust company as custodian with respect to any such U.S.
Government Obligation or a specific payment of interest on or principal of any such U.S. Government Obligation held by such custodian for the account of the holder of a depository receipt, provided that (except as required by law) such
custodian is not authorized to make any deduction from the amount payable to the holder of such depository receipt from any amount received by the custodian in respect of the U.S. Government Obligation evidenced by such depository receipt.

 Section 1.2. Other Definitions. 

 

					
	 TERM
	  	DEFINED IN
SECTION	 
	 “Bankruptcy Law”
	  	 	6.1  	  
	 “Custodian”
	  	 	6.1  	  
	 “Event of Default”
	  	 	6.1  	  
	 “Judgment Currency”
	  	 	10.16	  

  
 4 

					
	 “Legal Holiday”
	  	 	10.7  	  
	 “mandatory sinking fund payment”
	  	 	11.1  	  
	 “Market Exchange Rate”
	  	 	10.15	  
	 “New York Banking Day”
	  	 	10.16	  
	 “Notice Agent”
	  	 	2.4  	  
	 “optional sinking fund payment”
	  	 	11.1  	  
	 “Paying Agent”
	  	 	2.4  	  
	 “Registrar”
	  	 	2.4  	  
	 “Required Currency”
	  	 	10.16	  
	 “successor person”
	  	 	5.1  	  

 Section 1.3. Incorporation by Reference of Trust Indenture Act.

 Whenever this Indenture refers to a provision of the TIA, the provision is incorporated by reference in and
made a part of this Indenture. The following TIA terms used in this Indenture have the following meanings: 

“Commission” means the SEC. 
 “indenture securities” means the Securities. 
 “indenture
security holder” means a Securityholder. 
 “indenture to be qualified” means this Indenture.

 “indenture trustee” or “institutional trustee” means the Trustee. 

“obligor” on the indenture securities means the Company and any successor obligor upon the Securities. 

All other terms used in this Indenture that are defined by the TIA, defined by TIA reference to another statute or
defined by SEC rule under the TIA and not otherwise defined herein are used herein as so defined. 

Section 1.4. Rules of Construction. 

Unless the context otherwise requires: 

(a) a term has the meaning assigned to it; 

(b) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP;

 (c) “or” is not exclusive; 

(d) words in the singular include the plural, and in the plural include the singular; and 

(e) provisions apply to successive events and transactions. 

  
 5 

 ARTICLE II. 
 THE SECURITIES 
 Section 2.1. Issuable in Series.

 The aggregate principal amount of Securities that may be authenticated and delivered under this Indenture is
unlimited. The Securities may be issued in one or more Series. All Securities of a Series shall be identical except as may be set forth or determined in the manner provided in a Board Resolution, supplemental indenture or Officer’s Certificate
detailing the adoption of the terms thereof pursuant to authority granted under a Board Resolution. In the case of Securities of a Series to be issued from time to time, the Board Resolution, Officer’s Certificate or supplemental indenture
detailing the adoption of the terms thereof pursuant to authority granted under a Board Resolution may provide for the method by which specified terms (such as interest rate, maturity date, record date or date from which interest shall accrue) are
to be determined. Securities may differ between Series in respect of any matters, provided that all Series of Securities shall be equally and ratably entitled to the benefits of the Indenture. 

Section 2.2. Establishment of Terms of Series of Securities. 

At or prior to the issuance of any Securities within a Series, the following shall be established (as to the Series
generally, in the case of Subsection 2.2.1 and either as to such Securities within the Series or as to the Series generally in the case of Subsections 2.2.2 through 2.2.24) by or pursuant to a Board Resolution, and set forth or determined in the
manner provided in a Board Resolution, supplemental indenture hereto or Officer’s Certificate: 

2.2.1. the title (which shall distinguish the Securities of that particular Series from the Securities of any other
Series) and ranking (including the terms of any subordination provisions) of the Series; 
 2.2.2. the
price or prices (expressed as a percentage of the principal amount thereof) at which the Securities of the Series will be issued; 
 2.2.3. any limit upon the aggregate principal amount of the Securities of the Series which may be authenticated and delivered under this Indenture (except for Securities authenticated and delivered
upon registration of transfer of, or in exchange for, or in lieu of, other Securities of the Series pursuant to Section 2.7, 2.8, 2.11, 3.6 or 9.6); 
 2.2.4. the date or dates on which the principal of the Securities of the Series is payable; 
 2.2.5. the rate or rates (which may be fixed or variable) per annum or, if applicable, the method used to determine such rate or rates (including, but not limited to, any commodity, commodity index,
stock exchange index or financial index) at which the Securities of the Series shall bear interest, if any, the date or dates from which such interest, if any, shall accrue, the date or dates on which such interest, if any, shall commence and be
payable and any regular record date for the interest payable on any interest payment date; 

  
 6 

 2.2.6. the place or places where the principal of and interest, if any,
on the Securities of the Series shall be payable (and the method of such payment), where the Securities of such Series may be surrendered for registration of transfer or exchange and where notices and demands to or upon the Company in respect of the
Securities of such Series and this Indenture may be delivered; 
 2.2.7. if applicable, the period or
periods within which, the price or prices at which and the terms and conditions upon which the Securities of the Series may be redeemed, in whole or in part, at the option of the Company; 

2.2.8. the obligation, if any, of the Company to redeem or purchase the Securities of the Series pursuant to any
sinking fund or analogous provisions or at the option of a Holder thereof and the period or periods within which, the price or prices at which and the terms and conditions upon which Securities of the Series shall be redeemed or purchased, in whole
or in part, pursuant to such obligation; 
 2.2.9. the dates, if any, on which and the price or prices at
which the Securities of the Series will be repurchased by the Company at the option of the Holders thereof and other detailed terms and provisions of such repurchase obligations; 

2.2.10. if other than denominations of $1,000 and any integral multiple thereof, the denominations in which the
Securities of the Series shall be issuable; 
 2.2.11. the forms of the Securities of the Series and
whether the Securities will be issuable as Global Securities; 
 2.2.12. if other than the principal amount
thereof, the portion of the principal amount of the Securities of the Series that shall be payable upon declaration of acceleration of the maturity thereof pursuant to Section 6.2; 

2.2.13. the currency of denomination of the Securities of the Series, which may be Dollars or any Foreign Currency,
and if such currency of denomination is a composite currency, the agency or organization, if any, responsible for overseeing such composite currency; 
 2.2.14. the designation of the currency, currencies or currency units in which payment of the principal of and interest, if any, on the Securities of the Series will be made; 

2.2.15. if payments of principal of or interest, if any, on the Securities of the Series are to be made in one or
more currencies or currency units other than that or those in which such Securities are denominated, the manner in which the exchange rate with respect to such payments will be determined; 

2.2.16. the manner in which the amounts of payment of principal of or interest, if any, on the Securities of the
Series will be determined, if such amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity index, stock exchange index or financial index; 

  
 7 

 2.2.17. the provisions, if any, relating to any security provided for
the Securities of the Series; 
 2.2.18. any addition to, deletion of or change in the Events of Default
which applies to any Securities of the Series and any change in the right of the Trustee or the requisite Holders of such Securities to declare the principal amount thereof due and payable pursuant to Section 6.2; 

2.2.19. any addition to, deletion of or change in the covenants set forth in Articles IV or V which applies to
Securities of the Series; 
 2.2.20. any Depositaries, interest rate calculation agents, exchange rate
calculation agents or other agents with respect to Securities of such Series if other than those appointed herein; 
 2.2.21. the provisions, if any, relating to conversion or exchange of any Securities of such Series, including if applicable, the conversion or exchange price, the conversion or exchange period,
provisions as to whether conversion will be mandatory, at the option of the Holders thereof or at the option of the Company, the events requiring an adjustment of the conversion or exchange price and provisions affecting conversion or exchange if
such Series of Securities are redeemed; and 
 2.2.22. any other terms of the Securities of the Series
(which may supplement, modify or delete any provision of this Indenture insofar as it applies to such Series), including any terms that may be required under applicable law or regulations or advisable in connection with the marketing of Securities
of that Series. 
 All Securities of any one Series need not be issued at the same time and may be issued from
time to time, consistent with the terms of this Indenture, if so provided by or pursuant to the Board Resolution, supplemental indenture hereto or Officer’s Certificate referred to above. 

Section 2.3. Execution and Authentication. 

An Officer shall sign the Securities for the Company by manual or facsimile signature. 

If an Officer whose signature is on a Security no longer holds that office at the time the Security is authenticated, the
Security shall nevertheless be valid. 
 A Security shall not be valid until authenticated by the manual
signature of the Trustee or an authenticating agent. The signature shall be conclusive evidence that the Security has been authenticated under this Indenture. 
 The Trustee shall at any time, and from time to time, authenticate Securities for original issue in the principal amount provided in the Board Resolution, supplemental indenture hereto or Officer’s
Certificate, upon receipt by the Trustee of a Company Order. Each Security shall be dated the date of its authentication. 

  
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 The aggregate principal amount of Securities of any Series outstanding at
any time may not exceed any limit upon the maximum principal amount for such Series set forth in the Board Resolution, supplemental indenture hereto or Officer’s Certificate delivered pursuant to Section 2.2, except as provided in
Section 2.8. 
 Prior to the issuance of Securities of any Series, the Trustee shall have received and
(subject to Section 7.2) shall be fully protected in relying on: (a) the Board Resolution, supplemental indenture hereto or Officer’s Certificate establishing the form of the Securities of that Series or of Securities within that
Series and the terms of the Securities of that Series or of Securities within that Series, (b) an Officer’s Certificate complying with Section 10.4, and (c) an Opinion of Counsel complying with Section 10.4 and stating that
the Securities have been duly authorized and, when authenticated and delivered by the Trustee and issued by the Company, such Securities will be legally valid and binding obligations of the Company, enforceable against the Company in accordance with
their terms under the laws of the State of New York. 
 The Trustee shall have the right to decline to
authenticate and deliver any Securities of such Series: (a) if the Trustee, being advised by counsel, determines that such action may not be taken lawfully; or (b) if the Trustee in good faith by its board of directors or trustees,
executive committee or a trust committee of directors and/or vice-presidents or a committee of Responsible Officers shall determine that such action would expose the Trustee to personal liability to Holders of any then outstanding Series of
Securities. 
 The Trustee may appoint an authenticating agent acceptable to the Company to authenticate
Securities. An authenticating agent may authenticate Securities whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such agent. An authenticating agent has the same rights as
an Agent to deal with the Company or an Affiliate of the Company. 
 Section 2.4. Registrar and
Paying Agent. 
 The Company shall maintain, with respect to each Series of Securities, at the place or
places specified with respect to such Series pursuant to Section 2.2, an office or agency where Securities of such Series may be presented or surrendered for payment (“Paying Agent”), where Securities of such Series may be
surrendered for registration of transfer or exchange (“Registrar”) and where notices and demands to or upon the Company in respect of the Securities of such Series and this Indenture may be delivered (“Notice
Agent”). The Registrar shall keep a register with respect to each Series of Securities and to their transfer and exchange. The Company will give prompt written notice to the Trustee of the name and address, and any change in the name or
address, of each Registrar, Paying Agent or Notice Agent. If at any time the Company shall fail to maintain any such required Registrar, Paying Agent or Notice Agent or shall fail to furnish the Trustee with the name and address thereof, such
presentations, surrenders, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as its agent to receive all such presentations, surrenders, notices and demands.

 The Company may also from time to time designate one or more co-registrars, additional paying agents or
additional notice agents and may from time to time rescind such 

  
 9 

 
designations; provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligations to maintain a Registrar, Paying Agent and Notice
Agent in each place so specified pursuant to Section 2.2 for Securities of any Series for such purposes. The Company will give prompt written notice to the Trustee of any such designation or rescission and of any change in the name or address
of any such co-registrar, additional paying agent or additional notice agent. The term “Registrar” includes any co-registrar; the term “Paying Agent” includes any additional paying agent; and the term
“Notice Agent” includes any additional notice agent. The Company or any of its Affiliates may serve as Registrar or Paying Agent. 
 The Company hereby appoints the Trustee the initial Registrar, Paying Agent and Notice Agent for each Series unless another Registrar, Paying Agent or Notice Agent, as the case may be, is appointed prior
to the time Securities of that Series are first issued. 
 Section 2.5. Paying Agent to Hold Money
in Trust. 
 The Company shall require each Paying Agent other than the Trustee to agree in writing that the
Paying Agent will hold in trust, for the benefit of Securityholders of any Series of Securities, or the Trustee, all money held by the Paying Agent for the payment of principal of or interest on the Series of Securities, and will notify the Trustee
in writing of any default by the Company in making any such payment. While any such default continues, the Trustee may require a Paying Agent to pay all money held by it to the Trustee. The Company at any time may require a Paying Agent to pay all
money held by it to the Trustee. Upon payment over to the Trustee, the Paying Agent (if other than the Company or a Subsidiary of the Company) shall have no further liability for the money. If the Company or a Subsidiary of the Company acts as
Paying Agent, it shall segregate and hold in a separate trust fund for the benefit of Securityholders of any Series of Securities all money held by it as Paying Agent. Upon any bankruptcy, reorganization or similar proceeding with respect to the
Company, the Trustee shall serve as Paying Agent for the Securities. 
 Section 2.6. Securityholder
Lists. 
 The Trustee shall preserve in as current a form as is reasonably practicable the most recent list
available to it of the names and addresses of Securityholders of each Series of Securities and shall otherwise comply with TIA § 312(a). If the Trustee is not the Registrar, the Company shall furnish to the Trustee at least ten days before each
interest payment date and at such other times as the Trustee may request in writing a list, in such form and as of such date as the Trustee may reasonably require, of the names and addresses of Securityholders of each Series of Securities.

 Section 2.7. Transfer and Exchange. 

Where Securities of a Series are presented to the Registrar or a co-registrar with a request to register a transfer or to
exchange them for an equal principal amount of Securities of the same Series, the Registrar shall register the transfer or make the exchange if its requirements for such transactions are met. To permit registrations of transfers and exchanges, the
Trustee shall authenticate Securities at the Registrar’s request. No service charge shall be made for any 

  
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registration of transfer or exchange (except as otherwise expressly permitted herein), but the Company may require payment of a sum sufficient to cover any transfer tax or similar governmental
charge payable in connection therewith (other than any such transfer tax or similar governmental charge payable upon exchanges pursuant to Sections 2.11, 3.6 or 9.6). 

Neither the Company nor the Registrar shall be required (a) to issue, register the transfer of, or exchange
Securities of any Series for the period beginning at the opening of business fifteen days immediately preceding the mailing of a notice of redemption of Securities of that Series selected for redemption and ending at the close of business on the day
of such mailing, or (b) to register the transfer of or exchange Securities of any Series selected, called or being called for redemption as a whole or the portion being redeemed of any such Securities selected, called or being called for
redemption in part. 
 Each Holder of a Security agrees to indemnify the Company and the Trustee against any
liability that may result from the transfer, exchange or assignment of such Holder’s Security in violation of any provision of this Indenture and/or applicable United States Federal or state securities law. 

The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on
transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Security (including any transfers between or among Depositary participants or beneficial owners of interests in any Global Security)
other than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial
compliance as to form with the express requirements hereof. 
 Section 2.8. Mutilated, Destroyed,
Lost and Stolen Securities. 
 If any mutilated Security is surrendered to the Trustee, the Company shall
execute and the Trustee shall authenticate and deliver in exchange therefor a new Security of the same Series and of like tenor and principal amount and bearing a number not contemporaneously outstanding. 

If there shall be delivered to the Company and the Trustee (i) evidence to their satisfaction of the destruction,
loss or theft of any Security and (ii) such security or indemnity bond as may be required by each of them to hold itself and any of its agents harmless, then, in the absence of notice to the Company or the Trustee that such Security has been
acquired by a bona fide purchaser, the Company shall execute and upon its request the Trustee shall authenticate and make available for delivery, in lieu of any such destroyed, lost or stolen Security, a new Security of the same Series and of like
tenor and principal amount and bearing a number not contemporaneously outstanding. 
 In case any such
mutilated, destroyed, lost or stolen Security has become or is about to become due and payable, the Company in its discretion may, instead of issuing a new Security, pay such Security. 

  
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 Upon the issuance of any new Security under this Section, the Company may
require the payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith. 

Every new Security of any Series issued pursuant to this Section in lieu of any destroyed, lost or stolen Security shall
constitute an original additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be entitled to all the benefits of this Indenture equally and
proportionately with any and all other Securities of that Series duly issued hereunder. 
 The provisions of
this Section are exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities. 

Section 2.9. Outstanding Securities. 

The Securities outstanding at any time are all the Securities authenticated by the Trustee except for those canceled by
it, those delivered to it for cancellation, those reductions in the interest on a Global Security effected by the Trustee in accordance with the provisions hereof and those described in this Section as not outstanding. 

If a Security is replaced pursuant to Section 2.8, it ceases to be outstanding until the Trustee receives proof
satisfactory to it that the replaced Security is held by a bona fide purchaser. 
 If the Paying Agent (other
than the Company, a Subsidiary of the Company or an Affiliate of the Company) holds on the Maturity of Securities of a Series money sufficient to pay such Securities payable on that date, then on and after that date such Securities of the Series
cease to be outstanding and interest on them ceases to accrue. 
 The Company may purchase or otherwise acquire
the Securities, whether by open market purchases, negotiated transactions or otherwise. A Security does not cease to be outstanding because the Company or an Affiliate of the Company holds the Security. 

In determining whether the Holders of the requisite principal amount of outstanding Securities have given any request,
demand, authorization, direction, notice, consent or waiver hereunder, the principal amount of a Discount Security that shall be deemed to be outstanding for such purposes shall be the amount of the principal thereof that would be due and payable as
of the date of such determination upon a declaration of acceleration of the Maturity thereof pursuant to Section 6.2. 
 Section 2.10. Treasury Securities. 
 In
determining whether the Holders of the required principal amount of Securities of a Series have concurred in any request, demand, authorization, direction, notice, consent or waiver, Securities of a Series owned by the Company or any Affiliate of
the Company shall be disregarded, except that for the purposes of determining whether the Trustee shall be protected in 

  
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relying on any such request, demand, authorization, direction, notice, consent or waiver only Securities of a Series that a Responsible Officer of the Trustee knows are so owned shall be so
disregarded. 
 Section 2.11. Temporary Securities. 

Until definitive Securities are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary
Securities upon a Company Order. Temporary Securities shall be substantially in the form of definitive Securities but may have variations that the Company considers appropriate for temporary Securities. Without unreasonable delay, the Company shall
prepare and the Trustee upon receipt of a Company Order shall authenticate definitive Securities of the same Series and date of maturity in exchange for temporary Securities. Until so exchanged, temporary securities shall have the same rights under
this Indenture as the definitive Securities. 
 Section 2.12. Cancellation. 

The Company at any time may deliver Securities to the Trustee for cancellation. The Registrar and the Paying Agent shall
forward to the Trustee any Securities surrendered to them for registration of transfer, exchange or payment. The Trustee shall cancel all Securities surrendered for transfer, exchange, payment, replacement or cancellation and shall destroy such
canceled Securities (subject to the record retention requirement of the Exchange Act and the Trustee) and deliver a certificate of such cancellation to the Company upon written request of the Company. The Company may not issue new Securities to
replace Securities that it has paid or delivered to the Trustee for cancellation. 

Section 2.13. Defaulted Interest. 

If the Company defaults in a payment of interest on a Series of Securities, it shall pay the defaulted interest, plus, to
the extent permitted by law, any interest payable on the defaulted interest, to the persons who are Securityholders of the Series on a subsequent special record date. The Company shall fix the record date and payment date. At least 10 days before
the special record date, the Company shall mail to the Trustee and to each Securityholder of the Series a notice that states the special record date, the payment date and the amount of interest to be paid. The Company may pay defaulted interest in
any other lawful manner. 
 Section 2.14. Global Securities. 

2.14.1. Terms of Securities. A Board Resolution, a supplemental indenture hereto or an Officer’s
Certificate shall establish whether the Securities of a Series shall be issued in whole or in part in the form of one or more Global Securities and the Depositary for such Global Security or Securities. 

2.14.2. Transfer and Exchange. Notwithstanding any provisions to the contrary contained in Section 2.7
of the Indenture and in addition thereto, any Global Security shall be exchangeable pursuant to Section 2.7 of the Indenture for Securities registered in the names of Holders other than the Depositary for such Security or its nominee only if
(i) such Depositary notifies the Company that it is unwilling or unable to continue as Depositary for such 

  
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Global Security or if at any time such Depositary ceases to be a clearing agency registered under the Exchange Act, and, in either case, the Company fails to appoint a successor Depositary
registered as a clearing agency under the Exchange Act within 90 days of such event or (ii) the Company executes and delivers to the Trustee an Officer’s Certificate to the effect that such Global Security shall be so exchangeable. Any
Global Security that is exchangeable pursuant to the preceding sentence shall be exchangeable for Securities registered in such names as the Depositary shall direct in writing in an aggregate principal amount equal to the principal amount of the
Global Security with like tenor and terms. 
 Except as provided in this Section 2.14.2, a Global Security
may not be transferred except as a whole by the Depositary with respect to such Global Security to a nominee of such Depositary, by a nominee of such Depositary to such Depositary or another nominee of such Depositary or by the Depositary or any
such nominee to a successor Depositary or a nominee of such a successor Depositary. Neither the Trustee nor any Agent shall have any responsibility for any actions taken or not taken by the Depositary. 

2.14.3. Legend. Any Global Security issued hereunder shall bear a legend in substantially the following form:

 “This Security is a Global Security within the meaning of the Indenture hereinafter referred to and is
registered in the name of the Depositary or a nominee of the Depositary. This Security is exchangeable for Securities registered in the name of a person other than the Depositary or its nominee only in the limited circumstances described in the
Indenture, and may not be transferred except as a whole by the Depositary to a nominee of the Depositary, by a nominee of the Depositary to the Depositary or another nominee of the Depositary or by the Depositary or any such nominee to a successor
Depositary or a nominee of such a successor Depositary.” 
 2.14.4. Acts of Holders. The
Depositary, as a Holder, may appoint agents and otherwise authorize participants to give or take any request, demand, authorization, direction, notice, consent, waiver or other action which a Holder is entitled to give or take under the Indenture.

 2.14.5. Payments. Notwithstanding the other provisions of this Indenture, unless otherwise
specified as contemplated by Section 2.2, payment of the principal of and interest, if any, on any Global Security shall be made to the Holder thereof. 
 2.14.6. Consents, Declaration and Directions. The Company, the Trustee and any Agent shall treat a person as the Holder of such principal amount of outstanding Securities of such Series
represented by a Global Security as shall be specified in a written statement of the Depositary or by the applicable procedures of such Depositary with respect to such Global Security, for purposes of obtaining any consents, declarations, waivers or
directions required to be given by the Holders pursuant to this Indenture. 
 Section 2.15. CUSIP
Numbers. 
 The Company in issuing the Securities may use “CUSIP” numbers (if then generally in
use), and, if so, the Trustee shall use “CUSIP” numbers in notices of redemption as a 

  
 14 

 
convenience to Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in
any notice of a redemption and that reliance may be placed only on the other elements of identification printed on the Securities, and any such redemption shall not be affected by any defect in or omission of such numbers. 

ARTICLE III. 

REDEMPTION 
 Section 3.1. Notice to Trustee. 
 The Company may,
with respect to any Series of Securities, reserve the right to redeem and pay the Series of Securities or may covenant to redeem and pay the Series of Securities or any part thereof prior to the Stated Maturity thereof at such time and on such terms
as provided for in such Securities. If a Series of Securities is redeemable and the Company wants or is obligated to redeem prior to the Stated Maturity thereof all or part of the Series of Securities pursuant to the terms of such Securities, it
shall notify the Trustee in writing of the redemption date and the principal amount of Series of Securities to be redeemed. The Company shall give the notice at least 30 days but not more than 60 days before the redemption date. 

Section 3.2. Selection of Securities to be Redeemed. 

Unless otherwise indicated for a particular Series by a Board Resolution, a supplemental indenture hereto or an
Officer’s Certificate, if less than all the Securities of a Series are to be redeemed, the Trustee shall select the Securities of the Series to be redeemed in any manner that the Trustee deems fair and appropriate, including by lot or other
method, unless otherwise required by law or applicable stock exchange requirements, subject, in the case of Global Securities, to the applicable rules and procedures of the Depositary. The Trustee shall make the selection from Securities of the
Series outstanding not previously called for redemption. The Trustee may select for redemption portions of the principal of Securities of the Series that have denominations larger than $1,000. Securities of the Series and portions of them it selects
shall be in amounts of $1,000 or whole multiples of $1,000 or, with respect to Securities of any Series issuable in other denominations pursuant to Section 2.2.10, the minimum principal denomination for each Series and the authorized integral
multiples thereof. Provisions of this Indenture that apply to Securities of a Series called for redemption also apply to portions of Securities of that Series called for redemption. 

Section 3.3. Notice of Redemption. 

Unless otherwise indicated for a particular Series by Board Resolution, a supplemental indenture hereto or an
Officer’s Certificate, at least 30 days but not more than 60 days before a redemption date, the Company shall mail or cause to be mailed a notice of redemption by first-class mail to each Holder whose Securities are to be redeemed. 

The notice shall identify the Securities of the Series to be redeemed and shall state: 

(a) the redemption date; 

  
 15 

 (b) the redemption price; 

(c) the name and address of the Paying Agent; 

(d) if any Securities are being redeemed in part, the portion of the principal amount of such
Securities to be redeemed and that, after the redemption date and upon surrender of such Security, a new Security or Securities in principal amount equal to the unredeemed portion of the original Security shall be issued in the name of the Holder
thereof upon cancellation of the original Security; 
 (e) that Securities of the Series
called for redemption must be surrendered to the Paying Agent to collect the redemption price; 

(f) that interest on Securities of the Series called for redemption ceases to accrue on and after the
redemption date unless the Company defaults in the deposit of the redemption price; 

(g) the CUSIP number, if any; and 

(h) any other information as may be required by the terms of the particular Series or the Securities
of a Series being redeemed. 
 At the Company’s request, the Trustee shall give the notice of redemption in
the Company’s name and at its expense, provided, however, that the Company has delivered to the Trustee, at least 10 days (unless a shorter time shall be acceptable to the Trustee) prior to the notice date, an Officer’s Certificate
requesting that the Trustee give such notice and setting forth the information to be stated in such notice. 

Section 3.4. Effect of Notice of Redemption. 

Once notice of redemption is mailed as provided in Section 3.3, Securities of a Series called for redemption become
due and payable on the redemption date and at the redemption price. Except as otherwise provided in the supplemental indenture, Board Resolution or Officer’s Certificate for a Series, a notice of redemption may not be conditional. Upon
surrender to the Paying Agent, such Securities shall be paid at the redemption price plus accrued interest to the redemption date. 
 Section 3.5. Deposit of Redemption Price. 
 On or
before 11:00 a.m., New York City time, on the redemption date, the Company shall deposit with the Paying Agent money sufficient to pay the redemption price of and accrued interest, if any, on all Securities to be redeemed on that date. 

Section 3.6. Securities Redeemed in Part. 

Upon surrender of a Security that is redeemed in part, the Trustee shall authenticate for the Holder a new Security of the
same Series and the same maturity equal in principal amount to the unredeemed portion of the Security surrendered. 

  
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 ARTICLE IV. 
 COVENANTS 
 Section 4.1. Payment of Principal and
Interest. 
 The Company covenants and agrees for the benefit of the Holders of each Series of Securities
that it will duly and punctually pay the principal of and interest, if any, on the Securities of that Series in accordance with the terms of such Securities and this Indenture. Unless otherwise provided by Board Resolution, Officer’s
Certificate or supplemental indenture hereto for a particular Series, on or before 11:00 a.m., New York City time, on the applicable payment date, the Company shall deposit with the Paying Agent money sufficient to pay the principal of and interest,
if any, on the Securities of each Series in accordance with the terms of such Securities and this Indenture. 

Section 4.2. SEC Reports. 

To the extent any Securities of a Series are outstanding, the Company shall deliver to the Trustee within 15 days after it
files them with the SEC copies of the annual reports and of the information, documents, and other reports (or copies of such portions of any of the foregoing as the SEC may by rules and regulations prescribe) which the Company is required to file
with the SEC pursuant to Section 13 or 15(d) of the Exchange Act. The Company also shall comply with the other provisions of TIA § 314(a). Reports, information and documents filed with the SEC via the EDGAR system will be deemed to be
delivered to the Trustee as of the time of such filing via EDGAR for purposes of this Section 4.2. 

Delivery of reports, information and documents to the Trustee under this Section 4.2 are for informational purposes
only and the Trustee’s receipt of the foregoing shall not constitute constructive or actual notice of any information contained therein or determinable from information contained therein, including the Company’s compliance with any of
their covenants hereunder (as to which the Trustee is entitled to rely exclusively on Officer’s Certificates). 
 Section 4.3. Compliance Certificate. 
 To the
extent any Securities of a Series are outstanding, the Company shall deliver to the Trustee, within 120 days after the end of each fiscal year of the Company, an Officer’s Certificate stating that a review of the activities of the Company and
its Subsidiaries during the preceding fiscal year has been made under the supervision of the signing Officers with a view to determining whether the Company has kept, observed, performed and fulfilled its obligations under this Indenture, and
further stating, as to each such Officer signing such certificate, that to the best of his/her knowledge the Company has kept, observed, performed and fulfilled each and every covenant contained in this Indenture and is not in default in the
performance or observance of any of the terms, provisions and conditions hereof (or, if a Default or Event of Default shall have occurred, describing all such Defaults or Events of Default of which the Officer may have knowledge). 

  
 17 

 The Company will, so long as any of the Securities are outstanding, deliver
to the Trustee, promptly upon becoming aware of any Default or Event of Default, an Officer’s Certificate specifying such Default or Event of Default and what action the Company is taking or proposes to take with respect thereto. 

Section 4.4. Stay, Extension and Usury Laws. 

The Company covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, plead, or in
any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, which may affect the covenants or the performance of this Indenture or the Securities; and the
Company (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law and covenants that it will not, by resort to any such law, hinder, delay or impede the execution of any power herein granted to the
Trustee, but will suffer and permit the execution of every such power as though no such law has been enacted. 

Section 4.5. Corporate Existence. 

Subject to Article V, the Company will do or cause to be done all things necessary to preserve and keep in full force and
effect its corporate existence and rights (charter and statutory); provided, however, that the Company shall not be required to preserve any such right if the Board of Directors shall determine that the preservation thereof is no longer desirable in
the conduct of the business of the Company and its Subsidiaries taken as a whole and that the loss thereof is not adverse in any material respect to the Holders. 
 ARTICLE V. 
 SUCCESSORS 

Section 5.1. When Company May Merge, Etc. 

The Company shall not consolidate with or merge with or into, or convey, transfer or lease all or substantially all of its
properties and assets to, any person (a “successor person”) unless: 

(a) the Company is the surviving corporation or the successor person (if other than the Company) is a
corporation organized and validly existing under the laws of any U.S. domestic jurisdiction and expressly assumes the Company’s obligations on the Securities and under this Indenture; and 

(b) immediately after giving effect to the transaction, no Default or Event of Default, shall have
occurred and be continuing. 
 The Company shall deliver to the Trustee prior to the consummation of the
proposed transaction an Officer’s Certificate to the foregoing effect and an Opinion of Counsel stating that the proposed transaction and any supplemental indenture comply with this Indenture. 

  
 18 

 Notwithstanding the above, any Subsidiary of the Company may consolidate
with, merge into or transfer all or part of its properties to the Company. Neither an Officer’s Certificate nor an Opinion of Counsel shall be required to be delivered in connection therewith. 

Section 5.2. Successor Corporation Substituted. 

Upon any consolidation or merger, or any sale, lease, conveyance or other disposition of all or substantially all of the
assets of the Company in accordance with Section 5.1, the successor corporation formed by such consolidation or into or with which the Company is merged or to which such sale, lease, conveyance or other disposition is made shall succeed to, and
be substituted for, and may exercise every right and power of, the Company under this Indenture with the same effect as if such successor person has been named as the Company herein; provided, however, that the predecessor Company in
the case of a sale, conveyance or other disposition (other than a lease) shall be released from all obligations and covenants under this Indenture and the Securities. 
 ARTICLE VI. 
 DEFAULTS AND REMEDIES 

Section 6.1. Events of Default. 

“Event of Default,” wherever used herein with respect to Securities of any Series, means any one of the
following events, unless in the establishing Board Resolution, supplemental indenture or Officer’s Certificate, it is provided that such Series shall not have the benefit of said Event of Default: 

(a) default in the payment of any interest on any Security of that Series when it
becomes due and payable, and continuance of such default for a period of 30 days (unless the entire amount of such payment is deposited by the Company with the Trustee or with a Paying Agent prior to 11:00 a.m., New York City time, on the 30th day of such period); or 

(b) default in the payment of principal of any Security of that Series at its Maturity; or

 (c) default in the performance or breach of any covenant or warranty of the Company in
this Indenture (other than defaults pursuant to paragraphs (a) or (b) above or pursuant to a covenant or warranty that has been included in this Indenture solely for the benefit of a Series of Securities other than that Series), which
default continues uncured for a period of 60 days after there has been given, by registered or certified mail, to the Company by the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal amount of the outstanding
Securities of that Series a written notice specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice of Default” hereunder; or 

(d) the Company pursuant to or within the meaning of any Bankruptcy Law: 

(i) commences a voluntary case, 

  
 19 

 (ii) consents to the entry of an order for relief against it
in an involuntary case, 
 (iii) consents to the appointment of a Custodian of it or for all or
substantially all of its property, 
 (iv) makes a general assignment for the benefit of its
creditors, or 
 (v) generally is unable to pay its debts as the same become due; or 

(e) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:

 (i) is for relief against the Company in an involuntary case, 

(ii) appoints a Custodian of the Company or for all or substantially all of its property, or 

(iii) orders the liquidation of the Company, 

and the order or decree remains unstayed and in effect for 60 days; or 

(f) any other Event of Default provided with respect to Securities of that Series, which is specified
in a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate, in accordance with Section 2.2.18. 
 The term “Bankruptcy Law” means title 11, U.S. Code or any similar Federal or State law for the relief of debtors. The term “Custodian” means any receiver, trustee,
assignee, liquidator or similar official under any Bankruptcy Law. 
 Section 6.2. Acceleration of
Maturity; Rescission and Annulment. 
 If an Event of Default with respect to Securities of any Series at the
time outstanding occurs and is continuing (other than an Event of Default referred to in Section 6.1(d) or (e)) then in every such case the Trustee or the Holders of not less than 25% in principal amount of the outstanding Securities of that
Series may declare the principal amount (or, if any Securities of that Series are Discount Securities, such portion of the principal amount as may be specified in the terms of such Securities) of and accrued and unpaid interest, if any, on all of
the Securities of that Series to be due and payable immediately, by a notice in writing to the Company (and to the Trustee if given by Holders), and upon any such declaration such principal amount (or specified amount) and accrued and unpaid
interest, if any, shall become immediately due and payable. If an Event of Default specified in Section 6.1(d) or (e) shall occur, the principal amount (or specified amount) of and accrued and unpaid interest, if any, on all outstanding
Securities shall become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder. 
 At any time after such a declaration of acceleration with respect to any Series has been made and before a judgment or decree for payment of the money due has been obtained by

  
 20 

 
the Trustee as hereinafter in this Article provided, the Holders of a majority in principal amount of the outstanding Securities of that Series, by written notice to the Company and the Trustee,
may rescind and annul such declaration and its consequences if all Events of Default with respect to Securities of that Series, other than the non-payment of the principal and interest, if any, of Securities of that Series which have become due
solely by such declaration of acceleration, have been cured or waived as provided in Section 6.13. 
 No
such rescission shall affect any subsequent Default or impair any right consequent thereon. 

Section 6.3. Collection of Indebtedness and Suits for Enforcement by Trustee. 

The Company covenants that if 

(a) default is made in the payment of any interest on any Security when such interest becomes due and
payable and such default continues for a period of 30 days, or 
 (b) default is made in the
payment of principal of any Security at the Maturity thereof, or 
 (c) default is made in
the deposit of any sinking fund payment, if any, when and as due by the terms of a Security, 
 then, the Company will,
upon demand of the Trustee, pay to it, for the benefit of the Holders of such Securities, the whole amount then due and payable on such Securities for principal and interest and, to the extent that payment of such interest shall be legally
enforceable, interest on any overdue principal and any overdue interest at the rate or rates prescribed therefor in such Securities, and, in addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection,
including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 
 If the Company fails to pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, may institute a judicial proceeding for the collection of the sums so
due and unpaid, may prosecute such proceeding to judgment or final decree and may enforce the same against the Company or any other obligor upon such Securities and collect the moneys adjudged or deemed to be payable in the manner provided by law
out of the property of the Company or any other obligor upon such Securities, wherever situated. 
 If an Event
of Default with respect to any Securities of any Series occurs and is continuing, the Trustee may in its discretion proceed to protect and enforce its rights and the rights of the Holders of Securities of such Series by such appropriate judicial
proceedings as the Trustee shall deem most effectual to protect and enforce any such rights, whether for the specific enforcement of any covenant or agreement in this Indenture or in aid of the exercise of any power granted herein, or to enforce any
other proper remedy. 

  
 21 

 Section 6.4. Trustee May File Proofs of Claim. 

In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment,
composition or other judicial proceeding relative to the Company or any other obligor upon the Securities or the property of the Company or of such other obligor or their creditors, the Trustee (irrespective of whether the principal of the
Securities shall then be due and payable as therein expressed or by declaration or otherwise and irrespective of whether the Trustee shall have made any demand on the Company for the payment of overdue principal or interest) shall be entitled and
empowered, by intervention in such proceeding or otherwise, 
 (a) to file and prove a claim
for the whole amount of principal and interest owing and unpaid in respect of the Securities and to file such other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for the
reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and of the Holders allowed in such judicial proceeding, and 

(b) to collect and receive any moneys or other property payable or deliverable on any such claims and
to distribute the same, 
 and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in
any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any amount due it
for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 7.7. 

Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf
of any Holder any plan of reorganization, arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding.

 Section 6.5. Trustee May Enforce Claims Without Possession of Securities. 

All rights of action and claims under this Indenture or the Securities may be prosecuted and enforced by the Trustee
without the possession of any of the Securities or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of
judgment shall, after provision for the payment of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable benefit of the Holders of the Securities in respect of which such
judgment has been recovered. 
 Section 6.6. Application of Money Collected. 

Any money or property collected by the Trustee pursuant to this Article shall be applied in the following order, at the
date or dates fixed by the Trustee and, in case of the distribution of such money or property on account of principal or interest, upon presentation of 

  
 22 

 
the Securities and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid: 

First: To the payment of all amounts due the Trustee under Section 7.7; and 

Second: To the payment of the amounts then due and unpaid for principal of and interest on the Securities in respect of
which or for the benefit of which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on such Securities for principal and interest, respectively; and 

Third: To the Company. 
 Section 6.7. Limitation on Suits. 
 No Holder of
any Security of any Series shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, or for the appointment of a receiver or trustee, or for any other remedy hereunder, unless 

(a) such Holder has previously given written notice to the Trustee of a continuing Event of Default
with respect to the Securities of that Series; 
 (b) the Holders of not less than 25% in
principal amount of the outstanding Securities of that Series shall have made written request to the Trustee to institute proceedings in respect of such Event of Default in its own name as Trustee hereunder; 

(c) such Holder or Holders have offered to the Trustee indemnity or security satisfactory to the
Trustee against the costs, expenses and liabilities which might be incurred by the Trustee in compliance with such request; 
 (d) the Trustee for 60 days after its receipt of such notice, request and offer of indemnity has failed to institute any such proceeding; and 

(e) no direction inconsistent with such written request has been given to the Trustee during such
60-day period by the Holders of a majority in principal amount of the outstanding Securities of that Series; 
 it being
understood, intended and expressly covenanted by the Holder of every Security with every other Holder and the Trustee that no one or more of such Holders shall have any right in any manner whatever by virtue of, or by availing of, any provision of
this Indenture to affect, disturb or prejudice the rights of any other of such Holders, or to obtain or to seek to obtain priority or preference over any other of such Holders or to enforce any right under this Indenture, except in the manner herein
provided and for the equal and ratable benefit of all such Holders of the applicable Series. 

Section 6.8. Unconditional Right of Holders to Receive Principal and Interest. 

  
 23 

 Notwithstanding any other provision in this Indenture, the Holder of any
Security shall have the right, which is absolute and unconditional, to receive payment of the principal of and interest, if any, on such Security on the Maturity of such Security, included the Stated Maturity expressed in such Security (or, in the
case of redemption, on the redemption date) and to institute suit for the enforcement of any such payment, and such rights shall not be impaired without the consent of such Holder. 

Section 6.9. Restoration of Rights and Remedies. 

If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such
proceeding has been discontinued or abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case, subject to any determination in such proceeding, the Company, the Trustee and the Holders
shall be restored severally and respectively to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding had been instituted. 

Section 6.10. Rights and Remedies Cumulative. 

Except as otherwise provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities
in Section 2.8, no right or remedy herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be cumulative and
in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not, to the extent permitted by law, prevent
the concurrent assertion or employment of any other appropriate right or remedy. 

Section 6.11. Delay or Omission Not Waiver. 

No delay or omission of the Trustee or of any Holder of any Securities to exercise any right or remedy accruing upon any
Event of Default shall impair any such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy given by this Article or by law to the Trustee or to the Holders may be exercised from time
to time, and as often as may be deemed expedient, by the Trustee or by the Holders, as the case may be. 

Section 6.12. Control by Holders. 

The Holders of a majority in principal amount of the outstanding Securities of any Series shall have the right to direct
the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee, with respect to the Securities of such Series, provided that 

(a) such direction shall not be in conflict with any rule of law or with this Indenture, 

  
 24 

 (b) the Trustee may take any other action deemed proper
by the Trustee which is not inconsistent with such direction, 
 (c) subject to the
provisions of Section 6.1, the Trustee shall have the right to decline to follow any such direction if the Trustee in good faith shall, by a Responsible Officer of the Trustee, determine that the proceeding so directed would involve the Trustee
in personal liability, and 
 (d) prior to taking any action as directed under this
Section 6.12, the Trustee shall be entitled to indemnity satisfactory to it against the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction. 

Section 6.13. Waiver of Past Defaults. 

The Holders of not less than a majority in principal amount of the outstanding Securities of any Series may on behalf of
the Holders of all the Securities of such Series waive any past Default hereunder with respect to such Series and its consequences, except a Default in the payment of the principal of or interest on any Security of such Series (provided, however,
that the Holders of a majority in principal amount of the outstanding Securities of any Series may rescind an acceleration and its consequences, including any related payment default that resulted from such acceleration). Upon any such waiver, such
Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured, for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other Default or impair any right consequent
thereon. 
 Section 6.14. Undertaking for Costs. 

All parties to this Indenture agree, and each Holder of any Security by his acceptance thereof shall be deemed to have
agreed, that any court may in its discretion require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, the filing by any party
litigant in such suit of an undertaking to pay the costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the
merits and good faith of the claims or defenses made by such party litigant; but the provisions of this Section shall not apply to any suit instituted by the Trustee, to any suit instituted by any Holder, or group of Holders, holding in the
aggregate more than 10% in principal amount of the outstanding Securities of any Series, or to any suit instituted by any Holder for the enforcement of the payment of the principal of or interest on any Security on or after the Maturity of such
Security, included the Stated Maturity expressed in such Security (or, in the case of redemption, on the redemption date). 

ARTICLE VII. 

TRUSTEE 
 Section 7.1. Duties of Trustee. 

(a) If an Event of Default has occurred and is continuing, the Trustee shall exercise the rights and
powers vested in it by this Indenture and use the same degree of 

  
 25 

 
care and skill in their exercise as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs. 

(b) Except during the continuance of an Event of Default: 

(i) The Trustee need perform only those duties that are specifically set forth in this Indenture and no
implied covenants or obligations shall be read into this Indenture against the Trustee. 
 (ii)
In the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon Officer’s Certificates or Opinions of Counsel furnished to the Trustee and
conforming to the requirements of this Indenture; however, in the case of any such Officer’s Certificates or Opinions of Counsel which by any provisions hereof are specifically required to be furnished to the Trustee, the Trustee shall
examine such Officer’s Certificates and Opinions of Counsel to determine whether or not they conform to the form requirements of this Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other acts stated
therein). 
 (c) The Trustee may not be relieved from liability for its own negligent
action, its own negligent failure to act or its own willful misconduct, except that: 
 (i) This
paragraph does not limit the effect of paragraph (b) of this Section. 
 (ii) The Trustee
shall not be liable for any error of judgment made in good faith by a Responsible Officer, unless it is proved that the Trustee was negligent in ascertaining the pertinent facts. 

(iii) The Trustee shall not be liable with respect to any action taken, suffered or omitted to be taken by
it with respect to Securities of any Series in good faith in accordance with the direction of the Holders of a majority in principal amount of the outstanding Securities of such Series relating to the time, method and place of conducting any
proceeding for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture with respect to the Securities of such Series in accordance with Section 6.12. 

(d) Every provision of this Indenture that in any way relates to the Trustee is subject to paragraph
(a), (b) and (c) of this Section. 
 (e) The Trustee may refuse to perform any
duty or exercise any right or power unless it receives indemnity satisfactory to it against the costs, expenses and liabilities which might be incurred by it in performing such duty or exercising such right or power. 

  
 26 

 (f) The Trustee shall not be liable for interest on any
money received by it except as the Trustee may agree in writing with the Company. Money held in trust by the Trustee need not be segregated from other funds except to the extent required by law. 

(g) No provision of this Indenture shall require the Trustee to risk its own funds or otherwise incur
any financial liability in the performance of any of its duties, or in the exercise of any of its rights or powers, if adequate indemnity against such risk is not reasonably assured to the Trustee in its satisfaction. 

Section 7.2. Rights of Trustee. 

(a) The Trustee may rely on and shall be protected in acting or refraining from acting upon any
document (whether in its original or facsimile form) believed by it to be genuine and to have been signed or presented by the proper person. The Trustee need not investigate any fact or matter stated in the document. 

(b) Before the Trustee acts or refrains from acting, it may require an Officer’s Certificate or
an Opinion of Counsel or both. The Trustee shall not be liable for any action it takes or omits to take in good faith in reliance on such Officer’s Certificate or Opinion of Counsel. 

(c) The Trustee may act through agents and shall not be responsible for the misconduct or negligence
of any agent appointed with due care. No Depositary shall be deemed an agent of the Trustee and the Trustee shall not be responsible for any act or omission by any Depositary. 

(d) The Trustee shall not be liable for any action it takes or omits to take in good faith which it
believes to be authorized or within its rights or powers, provided that the Trustee’s conduct does not constitute willful misconduct or negligence. 

(e) The Trustee may consult with counsel and the advice of such counsel or any Opinion of Counsel
shall be full and complete authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith, and in reliance thereon. 

(f) The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by
this Indenture at the request or direction of any of the Holders of Securities unless such Holders shall have offered to the Trustee security or indemnity satisfactory to it against the costs, expenses and liabilities which might be incurred by it
in compliance with such request or direction. 
 (g) The Trustee shall not be bound to make
any investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document,
but the Trustee, in its discretion, may make such further inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to

  
 27 

 
examine the books, records and premises of the Company, personally or by agent or attorney at the sole cost of the Company. 

(h) The Trustee shall not be deemed to have notice of any Default or Event of Default unless a
Responsible Officer of the Trustee has actual knowledge thereof or unless written notice of any event which is in fact such a default is received by the Trustee at the Corporate Trust Office of the Trustee, and such notice references the Securities
generally or the Securities of a particular Series and this Indenture. 
 (i) In no event
shall the Trustee be liable to any person for special, punitive, indirect, consequential or incidental loss or damage of any kind whatsoever (including but not limited to lost profits), even if the Trustee has been advised of the likelihood of such
loss or damage. 
 (j) The permissive right of the Trustee to take the actions permitted by
this Indenture shall not be construed as an obligation or duty to do so. 
 (k) Any request
or direction of the Company mentioned herein shall be sufficiently evidenced by a Company Order and any resolution of the Board of Directors may be sufficiently evidenced by a Board Resolution. 

(l) The rights, privileges, protections, immunities and benefits given to the Trustee, including,
without limitation, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person employed to act hereunder. 

(m) The Trustee may request that the Company deliver a certificate setting forth the names of
individuals and/or titles of officers authorized at such time to take specified actions pursuant to this Indenture. 
 Section 7.3. Individual Rights of Trustee. 
 The
Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or an Affiliate of the Company with the same rights it would have if it were not Trustee. Any Agent may do the same
with like rights. The Trustee is also subject to Sections 7.10 and 7.11. 

Section 7.4. Trustee’s Disclaimer. 

The Trustee makes no representation as to the validity or adequacy of this Indenture or the Securities, it shall not be
accountable for the Company’s use of the proceeds from the Securities, and it shall not be responsible for any statement in the Securities other than its authentication. 

Section 7.5. Notice of Defaults. 

If a Default or Event of Default occurs and is continuing with respect to the Securities of any Series and if it is known
to a Responsible Officer of the Trustee, the Trustee 

  
 28 

 
shall mail to each Securityholder of the Securities of that Series notice of a Default or Event of Default within 90 days after a Responsible Officer of the Trustee has knowledge of such Default
or Event of Default. Except in the case of a Default or Event of Default in payment of principal of or interest on any Security of any Series, the Trustee may withhold the notice if and so long as its corporate trust committee or a committee of its
Responsible Officers in good faith determines that withholding the notice is in the interests of Securityholders of that Series. 
 Section 7.6. Reports by Trustee to Holders. 

Within 60 days after May 1 in each year, the Trustee shall transmit by mail to all Securityholders, as their names and
addresses appear on the register kept by the Registrar, a brief report dated as of such May 1, in accordance with, and to the extent required under, TIA § 313. 

A copy of each report at the time of its mailing to Securityholders of any Series shall be filed with the SEC and each
national securities exchange on which the Securities of that Series are listed. The Company shall promptly notify the Trustee in writing when Securities of any Series are listed on any national securities exchange. 

Section 7.7. Compensation and Indemnity. 

The Company shall pay to the Trustee from time to time compensation for its services as the Company and the Trustee shall
from time to time agree upon in writing. The Trustee’s compensation shall not be limited by any law on compensation of a trustee of an express trust. The Company shall reimburse the Trustee upon request for all reasonable out of pocket
expenses, disbursements and advances incurred by it. Such expenses shall include the reasonable compensation and expenses of the Trustee’s agents and counsel. 

The Company shall indemnify each of the Trustee and any predecessor Trustee (including the cost of defending itself)
against any cost, expense or liability, including taxes (other than taxes based upon, measured by or determined by the income of the Trustee) incurred by it except as set forth in the next paragraph in the performance of its duties under this
Indenture as Trustee or Agent. The Trustee shall notify the Company promptly of any claim for which it may seek indemnity. Failure by the Trustee to so notify the Company shall not relieve the Company of its obligations hereunder, unless and to the
extent that the Company is materially prejudiced thereby. The Company shall defend the claim and the Trustee shall cooperate in the defense. The Trustee may have one separate counsel and the Company shall pay the reasonable fees and expenses of such
counsel. The Company need not pay for any settlement made without its consent, which consent will not be unreasonably withheld. This indemnification shall apply to officers, directors, employees, shareholders and agents of the Trustee. 

The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee or by any
officer, director, employee, shareholder or agent of the Trustee through willful misconduct or negligence. 
 To
secure the Company’s payment obligations in this Section, the Trustee shall have a lien prior to the Securities of any Series on all money or property held or collected by the 

  
 29 

 
Trustee, except that held in trust to pay principal of and interest on particular Securities of that Series. 

When the Trustee incurs expenses or renders services after an Event of Default specified in Section 6.1(d) or
(e) occurs, the expenses and the compensation for the services are intended to constitute expenses of administration under any Bankruptcy Law. 
 The provisions of this Section shall survive the termination of this Indenture. 
 Section 7.8. Replacement of Trustee. 
 A
resignation or removal of the Trustee and appointment of a successor Trustee shall become effective only upon the successor Trustee’s acceptance of appointment as provided in this Section. 

The Trustee may resign with respect to the Securities of one or more Series by so notifying the Company at least 30 days
prior to the date of the proposed resignation. The Holders of a majority in principal amount of the Securities of any Series may remove the Trustee with respect to that Series by so notifying the Trustee and the Company. The Company may remove the
Trustee with respect to Securities of one or more Series if: 
 (a) the Trustee fails to
comply with Section 7.10; 
 (b) the Trustee is adjudged a bankrupt or an insolvent or
an order for relief is entered with respect to the Trustee under any Bankruptcy Law; 

(c) a Custodian or public officer takes charge of the Trustee or its property; or 

(d) the Trustee becomes incapable of acting. 

If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall
promptly appoint a successor Trustee. Within one year after the successor Trustee takes office, the Holders of a majority in principal amount of the then outstanding Securities may appoint a successor Trustee to replace the successor Trustee
appointed by the Company. 
 If a successor Trustee with respect to the Securities of any one or more Series
does not take office within 60 days after the retiring Trustee resigns or is removed, the retiring Trustee, the Company or the Holders of at least a majority in principal amount of the Securities of the applicable Series may petition any court of
competent jurisdiction for the appointment of a successor Trustee. 
 A successor Trustee shall deliver a
written acceptance of its appointment to the retiring Trustee and to the Company. Immediately after that, the retiring Trustee shall transfer all property held by it as Trustee to the successor Trustee subject to the lien provided for in
Section 7.7, the resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights, powers and duties of the Trustee with respect to each Series of Securities for which it is acting as
Trustee under this Indenture. A successor Trustee 

  
 30 

 
shall mail a notice of its succession to each Securityholder of each such Series. Notwithstanding replacement of the Trustee pursuant to this Section 7.8, the Company’s obligations
under Section 7.7 hereof shall continue for the benefit of the retiring Trustee with respect to expenses and liabilities incurred by it for actions taken or omitted to be taken in accordance with its rights, powers and duties under this
Indenture prior to such replacement. 
 Section 7.9. Successor Trustee by Merger, Etc.

 If the Trustee consolidates with, merges or converts into, or transfers all or substantially all of its
corporate trust business to, another corporation, the successor corporation without any further act shall be the successor Trustee, subject to Section 7.10. 

Section 7.10. Eligibility; Disqualification. 

This Indenture shall always have a Trustee who satisfies the requirements of TIA § 310(a)(1), (2) and (5). The
Trustee shall always have a combined capital and surplus of at least $25,000,000 as set forth in its most recent published annual report of condition. The Trustee shall comply with TIA § 310(b). 

Section 7.11. Preferential Collection of Claims Against Company. 

The Trustee is subject to TIA § 311(a), excluding any creditor relationship listed in TIA § 311(b). A Trustee
who has resigned or been removed shall be subject to TIA § 311(a) to the extent indicated. 
 ARTICLE VIII. 

SATISFACTION AND DISCHARGE; DEFEASANCE 
 Section 8.1. Satisfaction and Discharge of Indenture. 
 This Indenture shall upon Company Order cease to be of further effect (except as hereinafter provided in this Section 8.1), and the Trustee, at the expense of the Company, shall execute instruments
acknowledging satisfaction and discharge of this Indenture, when 
 (a) either 

(i) all Securities theretofore authenticated and delivered (other than Securities that have been
destroyed, lost or stolen and that have been replaced or paid) have been delivered to the Trustee for cancellation; or 
 (ii) all such Securities not theretofore delivered to the Trustee for cancellation 
 (1) have become due and payable, or 
 (2) will
become due and payable at their Stated Maturity within one year, or 

  
 31 

 (3) have been called for redemption or are to be called for
redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company, or 

(4) are deemed paid and discharged pursuant to Section 8.3, as applicable; 

and the Company, in the case of (1), (2) or (3) above, has irrevocably deposited or caused to be deposited with the Trustee as
trust funds in trust an amount sufficient for the purpose of paying and discharging the entire indebtedness on such Securities not theretofore delivered to the Trustee for cancellation, for principal and interest to the date of such deposit (in the
case of Securities which have become due and payable on or prior to the date of such deposit) or to the Stated Maturity or redemption date, as the case may be; 

(b) the Company has paid or caused to be paid all other sums payable hereunder by the Company; and

 (c) the Company has delivered to the Trustee an Officer’s Certificate and an Opinion
of Counsel, each stating that all conditions precedent herein provided for relating to the satisfaction and discharge of this Indenture have been complied with. 

Notwithstanding the satisfaction and discharge of this Indenture, the obligations of the Company to the Trustee under
Section 7.7, and, if money shall have been deposited with the Trustee pursuant to clause (a) of this Section, the provisions of Sections 2.4, 2.7, 2.8, 8.2 and 8.5 shall survive. 

Section 8.2. Application of Trust Funds; Indemnification. 

(a) Subject to the provisions of Section 8.5, all money deposited with the Trustee pursuant to
Section 8.1, all money and U.S. Government Obligations or Foreign Government Obligations deposited with the Trustee pursuant to Section 8.3 or 8.4 and all money received by the Trustee in respect of U.S. Government Obligations or Foreign
Government Obligations deposited with the Trustee pursuant to Section 8.3 or 8.4, shall be held in trust and applied by it, in accordance with the provisions of the Securities and this Indenture, to the payment, either directly or through any
Paying Agent (including the Company acting as its own Paying Agent) as the Trustee may determine, to the persons entitled thereto, of the principal and interest for whose payment such money has been deposited with or received by the Trustee or to
make mandatory sinking fund payments or analogous payments as contemplated by Sections 8.3 or 8.4. 
 (b) The Company shall pay and shall indemnify the Trustee against any tax, fee or other charge imposed on or assessed against U.S. Government Obligations or Foreign Government Obligations deposited
pursuant to Sections 8.3 or 8.4 or the interest and principal received in respect of such obligations other than any payable by or on behalf of Holders. 

  
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 (c) The Trustee shall deliver or pay to the Company
from time to time upon Company Order any U.S. Government Obligations or Foreign Government Obligations or money held by it as provided in Sections 8.3 or 8.4 which, in the opinion of a nationally recognized firm of independent certified public
accountants expressed in a written certification thereof delivered to the Trustee, are then in excess of the amount thereof which then would have been required to be deposited for the purpose for which such U.S. Government Obligations or Foreign
Government Obligations or money were deposited or received. This provision shall not authorize the sale by the Trustee of any U.S. Government Obligations or Foreign Government Obligations held under this Indenture. 

Section 8.3. Legal Defeasance of Securities of any Series. 

Unless this Section 8.3 is otherwise specified, pursuant to Section 2.2.20, to be inapplicable to Securities of
any Series, the Company shall be deemed to have paid and discharged the entire indebtedness on all the outstanding Securities of any Series on the 91st day after the date of the deposit referred to in subparagraph (d) hereof, and the provisions
of this Indenture, as it relates to such outstanding Securities of such Series, shall no longer be in effect (and the Trustee, at the expense of the Company, shall, upon receipt of a Company Order, execute proper instruments acknowledging the same),
except as to: 
 (a) the rights of Holders of Securities of such Series to receive, from the
trust funds described in subparagraph (d) hereof, (i) payment of the principal of and each installment of principal of and interest on the outstanding Securities of such Series on the Maturity of such principal or installment of principal
or interest and (ii) the benefit of any mandatory sinking fund payments applicable to the Securities of such Series on the day on which such payments are due and payable in accordance with the terms of this Indenture and the Securities of such
Series; 
 (b) the provisions of Sections 2.4, 2.7, 2.8, 8.2, 8.3 and 8.5; and 

(c) the rights, powers, trust and immunities of the Trustee hereunder and the Company’s
obligations in connection therewith; 
 provided that, the following conditions shall have been satisfied: 

(d) the Company shall have deposited or caused to be irrevocably deposited (except as provided in
Section 8.2(c)) with the Trustee as trust funds in trust for the purpose of making the following payments, specifically pledged as security for and dedicated solely to the benefit of the Holders of such Securities (i) in the case of
Securities of such Series denominated in Dollars, cash in Dollars and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated in a Foreign Currency (other than a composite currency), money and/or Foreign
Government Obligations, which through the payment of interest and principal in respect thereof in accordance with their terms, will provide (and without reinvestment and assuming no tax liability will be imposed on such Trustee), not later than one
day before the due date of any payment of money, an amount in cash, sufficient, in the opinion of a nationally 

  
 33 

 
recognized firm of independent public accountants or investment bank expressed in a written certification thereof delivered to the Trustee, to pay and discharge each installment of principal of
and interest, if any, on and any mandatory sinking fund payments in respect of all the Securities of such Series on the dates such installments of interest or principal and such sinking fund payments are due; 

(e) such deposit will not result in a breach or violation of, or constitute a default under, this
Indenture or any other agreement or instrument to which the Company is a party or by which it is bound; 
 (f) no Default or Event of Default with respect to the Securities of such Series shall have occurred and be continuing on the date of such deposit or during the period ending on the 91st day after
such date; 
 (g) the Company shall have delivered to the Trustee an Officer’s
Certificate and an Opinion of Counsel to the effect that (i) the Company has received from, or there has been published by, the Internal Revenue Service a ruling, or (ii) since the date of execution of this Indenture, there has been a
change in the applicable Federal income tax law, in either case to the effect that, and based thereon such Opinion of Counsel shall confirm that, the Holders of the Securities of such Series will not recognize income, gain or loss for Federal income
tax purposes as a result of such deposit, defeasance and discharge and will be subject to Federal income tax on the same amount and in the same manner and at the same times as would have been the case if such deposit, defeasance and discharge had
not occurred; 
 (h) the Company shall have delivered to the Trustee an Officer’s
Certificate stating that the deposit was not made by the Company with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and 

(i) the Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of
Counsel, each stating that all conditions precedent provided for relating to the defeasance contemplated by this Section have been complied with. 
 Section 8.4. Covenant Defeasance. 
 Unless this
Section 8.4 is otherwise specified pursuant to Section 2.2.20 to be inapplicable to Securities of any Series, the Company may omit to comply with respect to the Securities of any Series with any term, provision or condition set forth under
Sections 4.2, 4.3, 4.4, 4.5, and 5.1 as well as any additional covenants specified in a supplemental indenture for such Series of Securities or a Board Resolution or an Officer’s Certificate delivered pursuant to Section 2.2.20 (and the
failure to comply with any such covenants shall not constitute a Default or Event of Default with respect to such Series under Section 6.1) and the occurrence of any event specified in a supplemental indenture for such Series of Securities or a
Board Resolution or an Officer’s Certificate delivered pursuant to Section 2.2.18 and designated as an Event of Default shall not constitute a Default or Event of Default hereunder, with respect to the Securities of such Series, provided
that the following conditions shall have been satisfied: 

  
 34 

 (a) With reference to this Section 8.4, the
Company has deposited or caused to be irrevocably deposited (except as provided in Section 8.2(c)) with the Trustee as trust funds in trust for the purpose of making the following payments specifically pledged as security for, and dedicated
solely to, the benefit of the Holders of such Securities (i) in the case of Securities of such Series denominated in Dollars, cash in Dollars and/or U.S. Government Obligations, or (ii) in the case of Securities of such Series denominated
in a Foreign Currency (other than a composite currency), money and/or Foreign Government Obligations, which through the payment of interest and principal in respect thereof in accordance with their terms, will provide (and without reinvestment and
assuming no tax liability will be imposed on such Trustee), not later than one day before the due date of any payment of money, an amount in cash, sufficient, in the opinion of a nationally recognized firm of independent certified public accountants
or investment bank expressed in a written certification thereof delivered to the Trustee, to pay and discharge each installment of principal of and interest, if any, on and any mandatory sinking fund payments in respect of the Securities of such
Series on the dates such installments of interest or principal and such sinking fund payments are due; 
 (b) Such deposit will not result in a breach or violation of, or constitute a default under, this Indenture or any other agreement or instrument to which the Company is a party or by which it is
bound; 
 (c) No Default or Event of Default with respect to the Securities of such Series
shall have occurred and be continuing on the date of such deposit; 
 (d) The Company shall
have delivered to the Trustee an Opinion of Counsel to the effect that Holders of the Securities of such Series will not recognize income, gain or loss for federal income tax purposes as a result of such deposit and covenant defeasance and will be
subject to federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such deposit and covenant defeasance had not occurred; 

(e) The Company shall have delivered to the Trustee an Officer’s Certificate stating the deposit
was not made by the Company with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company; and 
 (f) The Company shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that all conditions precedent herein provided for relating to the covenant
defeasance contemplated by this Section have been complied with. 
 Section 8.5. Repayment to
Company. 
 Subject to applicable abandoned property law, the Trustee and the Paying Agent shall pay to the
Company upon request any money held by them for the payment of principal and interest that remains unclaimed for two years. After that, Securityholders entitled to the money must look to the Company for payment as general creditors unless an
applicable abandoned property law designates another person. 

  
 35 

 Section 8.6. Reinstatement. 

If the Trustee or the Paying Agent is unable to apply any money deposited with respect to Securities of any Series in
accordance with Section 8.1 by reason of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or otherwise prohibiting such application, the obligations of the Company under
this Indenture with respect to the Securities of such Series and under the Securities of such Series shall be revived and reinstated as though no deposit had occurred pursuant to Section 8.1 until such time as the Trustee or the Paying Agent is
permitted to apply all such money in accordance with Section 8.1; provided, however, that if the Company has made any payment of principal of or interest on or any Additional Amounts with respect to any Securities because of the
reinstatement of its obligations, the Company shall be subrogated to the rights of the Holders of such Securities to receive such payment from the money held by the Trustee or Paying Agent. 

ARTICLE IX. 

AMENDMENTS AND WAIVERS 
 Section 9.1. Without Consent of Holders. 
 The
Company and the Trustee may amend or supplement this Indenture or the Securities of one or more Series without the consent of any Securityholder: 

(a) to cure any ambiguity, defect or inconsistency; 

(b) to comply with Article V; 

(c) to provide for uncertificated Securities in addition to or in place of certificated Securities;

 (d) to make any change that does not adversely affect the rights of any Securityholder;

 (e) to provide for the issuance of and establish the form and terms and conditions of
Securities of any Series as permitted by this Indenture; 
 (f) to evidence and provide for
the acceptance of appointment hereunder by a successor Trustee with respect to the Securities of one or more Series and to add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration
of the trusts hereunder by more than one Trustee; or 
 (g) to comply with requirements of
the SEC in order to effect or maintain the qualification of this Indenture under the TIA. 

Section 9.2. With Consent of Holders. 

The Company and the Trustee may enter into a supplemental indenture with the written consent of the Holders of at least a
majority in principal amount of the outstanding Securities of each Series affected by such supplemental indenture (including consents obtained in 

  
 36 

 
connection with a tender offer or exchange offer for the Securities of such Series), for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of
this Indenture or of any supplemental indenture or of modifying in any manner the rights of the Securityholders of each such Series. Except as provided in Section 6.13, the Holders of at least a majority in principal amount of the outstanding
Securities of any Series by notice to the Trustee (including consents obtained in connection with a tender offer or exchange offer for the Securities of such Series) may waive compliance by the Company with any provision of this Indenture or the
Securities with respect to such Series. 
 It shall not be necessary for the consent of the Holders of
Securities under this Section 9.2 to approve the particular form of any proposed supplemental indenture or waiver, but it shall be sufficient if such consent approves the substance thereof. After a supplemental indenture or waiver under this
section becomes effective, the Company shall mail to the Holders of Securities affected thereby, a notice briefly describing the supplemental indenture or waiver. Any failure by the Company to mail or publish such notice, or any defect therein,
shall not, however, in any way impair or affect the validity of any such supplemental indenture or waiver. 

Section 9.3. Limitations. 

Without the consent of each Securityholder affected, an amendment or waiver may not: 

(a) reduce the principal amount of Securities whose Holders must consent to an amendment, supplement
or waiver; 
 (b) reduce the rate of or extend the time for payment of interest (including
default interest) on any Security; 
 (c) reduce the principal or change the Stated Maturity
of any Security or reduce the amount of, or postpone the date fixed for, the payment of any sinking fund or analogous obligation; 
 (d) reduce the principal amount of Discount Securities payable upon acceleration of the maturity thereof; 

(e) waive a Default or Event of Default in the payment of the principal of or interest, if any, on
any Security (except a rescission of acceleration of the Securities of any Series by the Holders of at least a majority in principal amount of the outstanding Securities of such Series and a waiver of the payment default that resulted from such
acceleration); 
 (f) make the principal of or interest, if any, on any Security payable in
any currency other than that stated in the Security; 
 (g) make any change in Sections 6.8,
6.13 or 9.3 (this sentence); or 
 (h) waive a redemption payment with respect to any
Security, provided that such redemption is made at the Company’s option. 

  
 37 

 Section 9.4. Compliance with Trust Indenture Act.

 Every amendment to this Indenture or the Securities of one or more Series shall be set forth in a supplemental
indenture hereto that complies with the TIA as then in effect. 
 Section 9.5. Revocation and
Effect of Consents. 
 Until an amendment is set forth in a supplemental indenture or a waiver becomes
effective, a consent to it by a Holder of a Security is a continuing consent by the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security, even if notation of
the consent is not made on any Security. However, any such Holder or subsequent Holder may revoke the consent as to his Security or portion of a Security if the Trustee receives the notice of revocation before the date of the supplemental indenture
or the date the waiver becomes effective. 
 Any amendment or waiver once effective shall bind every
Securityholder of each Series affected by such amendment or waiver unless it is of the type described in any of clauses (a) through (h) of Section 9.3. In that case, the amendment or waiver shall bind each Holder of a Security who has
consented to it and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security. 
 Section 9.6. Notation on or Exchange of Securities. 
 The Trustee may place an appropriate notation about an amendment or waiver on any Security of any Series thereafter authenticated. The Company in exchange for Securities of that Series may issue and the
Trustee shall authenticate upon request new Securities of that Series that reflect the amendment or waiver. 

Section 9.7. Trustee Protected. 
 In executing, or accepting the additional trusts created by, any supplemental indenture permitted by this Article or the modifications thereby of the trusts created by this Indenture, the Trustee shall be
entitled to receive, and (subject to Section 7.1) shall be fully protected in relying upon, an Officer’s Certificate or an Opinion of Counsel or both stating that the execution of such supplemental indenture is authorized or permitted by
this Indenture and that all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with. The Trustee shall sign all supplemental indentures authorized or permitted by this Indenture, except
that the Trustee need not sign any supplemental indenture that adversely affects its rights. 
 ARTICLE X. 

MISCELLANEOUS 
 Section 10.1. Trust Indenture Act Controls. 
 If
any provision of this Indenture limits, qualifies, or conflicts with another provision which is required or deemed to be included in this Indenture by the TIA, such required or deemed provision shall control. 

  
 38 

 Section 10.2. Notices. 

Any notice or communication by the Company or the Trustee to the other, or by a Holder to the Company or the Trustee, is
duly given if in writing and delivered in person or mailed by first-class mail: 
 if to the Company: 

InterMune, Inc. 
 3280 Bayshore Boulevard 
 Brisbane, California 94005 

Attention: General Counsel 
 Telephone: (415) 466-2200 
 with a copy to: 

Latham & Watkins LLP 
 140 Scott Drive 
 Menlo Park, CA 94025 

Attention: Mark V. Roeder, Esq. 
 Telephone: (650) 328-4600 
 if to the Trustee: 

The Bank of New York Mellon Trust Company, N.A. 
 700 South Flower St., Suite 500 
 Los Angeles, California 91007 

Attention: Corporate Trust Unit 
 Telephone: (213) 630-6489 
 The Company or the Trustee by
notice to the other may designate additional or different addresses for subsequent notices or communications. 

Any notice or communication to a Securityholder shall be mailed by first-class mail to his address shown on the register
kept by the Registrar. Failure to mail a notice or communication to a Securityholder of any Series or any defect in it shall not affect its sufficiency with respect to other Securityholders of that or any other Series. 

If a notice or communication is mailed or published in the manner provided above, within the time prescribed, it is duly
given, whether or not the Securityholder receives it. 
 If the Company mails a notice or communication to
Securityholders, it shall mail a copy to the Trustee and each Agent at the same time. 
 Notwithstanding any
other provision of this Indenture or any Security, where this Indenture or any Security provides for notice of any event (including any notice of redemption) 

  
 39 

 
to a Holder of a Global Security (whether by mail or otherwise), such notice shall be sufficiently given to the Depositary for such Security (or its designee) pursuant to the customary procedures
of such Depositary. 
 In addition to the foregoing, the Trustee agrees to accept and act upon notice,
instructions or directions pursuant to this Indenture sent by unsecured e-mail, facsimile transmission or other similar unsecured electronic methods. If the party elects to give the Trustee e-mail or facsimile instructions (or instructions by a
similar electronic method) and the Trustee in its discretion elects to act upon such instructions, the Trustee’s understanding of such instructions shall be deemed controlling. The Trustee shall not be liable for any losses, costs or expenses
arising directly or indirectly from the Trustee’s reliance upon and compliance with such instructions notwithstanding such instructions conflict or are inconsistent with a subsequent written instruction. The party providing electronic
instructions agrees to assume all risks arising out of the use of such electronic methods to submit instructions and directions to the Trustee, including without limitation the risk of the Trustee acting on unauthorized instructions, and the risk or
interception and misuse by third parties. 
 Section 10.3. Communication by Holders with Other
Holders. 
 Securityholders of any Series may communicate pursuant to TIA § 312(b) with other
Securityholders of that Series or any other Series with respect to their rights under this Indenture or the Securities of that Series or all Series. The Company, the Trustee, the Registrar and anyone else shall have the protection of TIA §
312(c). 
 Section 10.4. Certificate and Opinion as to Conditions Precedent. 

Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company shall
furnish to the Trustee: 
 (a) an Officer’s Certificate stating that, in the opinion of
the signers, all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with; and 
 (b) an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent have been complied with. 

Section 10.5. Statements Required in Certificate or Opinion. 

Each certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture (other
than a certificate provided pursuant to TIA § 314(a)(4)) shall comply with the provisions of TIA § 314(e) and shall include: 
 (a) a statement that the person making such certificate or opinion has read such covenant or condition; 

(b) a brief statement as to the nature and scope of the examination or investigation upon which the
statements or opinions contained in such certificate or opinion are based; 

  
 40 

 (c) a statement that, in the opinion of such person, he
has made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been complied with; and 

(d) a statement as to whether or not, in the opinion of such person, such condition or covenant has
been complied with. 
 Section 10.6. Rules by Trustee and Agents. 

The Trustee may make reasonable rules for action by or a meeting of Securityholders of one or more Series. Any Agent may
make reasonable rules and set reasonable requirements for its functions. 
 Section 10.7. Legal
Holidays. 
 Unless otherwise provided by Board Resolution, Officer’s Certificate or supplemental
indenture hereto for a particular Series, a “Legal Holiday” is any day that is not a Business Day. If a payment date is a Legal Holiday at a place of payment, payment may be made at that place on the next succeeding day that is not
a Legal Holiday, and no interest shall accrue for the intervening period. 
 Section 10.8. No
Recourse Against Others. 
 A director, officer, employee or stockholder (past or present), as such, of the
Company shall not have any liability for any obligations of the Company under the Securities or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. Each Securityholder by accepting a Security
waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Securities. 
 Section 10.9. Counterparts. 
 This Indenture may
be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. 

Section 10.10. Governing Laws. 

THIS INDENTURE AND THE SECURITIES, INCLUDING ANY CLAIM OR CONTROVERSY ARISING OUT OF OR RELATING TO THE INDENTURE OR
THE SECURITIES, SHALL BE GOVERNED BY THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO CONFLICT OF LAW PRINCIPLES THAT WOULD RESULT IN THE APPLICATION OF ANY LAW OTHER THAN THE LAW OF THE STATE OF NEW YORK. 

Section 10.11. No Adverse Interpretation of Other Agreements. 

  
 41 

 This Indenture may not be used to interpret another indenture, loan or debt
agreement of the Company or a Subsidiary of the Company. Any such indenture, loan or debt agreement may not be used to interpret this Indenture. 
 Section 10.12. Successors. 
 All agreements of the
Company in this Indenture and the Securities shall bind its successor. All agreements of the Trustee in this Indenture shall bind its successor. 
 Section 10.13. Severability. 
 In case any
provision in this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 10.14. Table of Contents, Headings, Etc. 

The Table of Contents, Cross Reference Table, and headings of the Articles and Sections of this Indenture have been
inserted for convenience of reference only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 

Section 10.15. Securities in a Foreign Currency. 

Unless otherwise specified in a Board Resolution, a supplemental indenture hereto or an Officer’s Certificate
delivered pursuant to Section 2.2 of this Indenture with respect to a particular Series of Securities, whenever for purposes of this Indenture any action may be taken by the Holders of a specified percentage in aggregate principal amount of
Securities of all Series or all Series affected by a particular action at the time outstanding and, at such time, there are outstanding Securities of any Series which are denominated in a coin or currency other than Dollars, then the principal
amount of Securities of such Series which shall be deemed to be outstanding for the purpose of taking such action shall be that amount of Dollars that could be obtained for such amount at the Market Exchange Rate at such time. For purposes of this
Section 10.15, “Market Exchange Rate” shall mean the noon Dollar buying rate in New York City for cable transfers of that currency as published by the Federal Reserve Bank of New York as of the relevant measurement date. If
such Market Exchange Rate is not available for any reason with respect to such currency, the Company shall use, without liability on its part, such quotation of the Federal Reserve Bank of New York as of the most recent available date, or quotations
from one or more major banks in The City of New York or in the country of issue of the currency in question or such other quotations as the Company shall deem appropriate. The provisions of this paragraph shall apply in determining the equivalent
principal amount in respect of Securities of a Series denominated in currency other than Dollars in connection with any action taken by Holders of Securities pursuant to the terms of this Indenture. 

All decisions and determinations regarding the Market Exchange Rate or any alternative determination provided for in the
preceding paragraph shall, in the absence of manifest error, to the extent permitted by law, be conclusive for all purposes and irrevocably binding upon the Trustee and all Holders. 

  
 42 

 Section 10.16. Judgment Currency. 

The Company agrees, to the fullest extent that it may effectively do so under applicable law, that (a) if for the
purpose of obtaining judgment in any court it is necessary to convert the sum due in respect of the principal of or interest or other amount on the Securities of any Series (the “Required Currency”) into a currency in which a
judgment will be rendered (the “Judgment Currency”), the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Trustee could purchase in The City of New York the Required Currency with the
Judgment Currency on the day on which final unappealable judgment is entered, unless such day is not a New York Banking Day, then the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Company could
purchase in The City of New York the Required Currency with the Judgment Currency on the New York Banking Day preceding the day on which final unappealable judgment is entered and (b) its obligations under this Indenture to make payments in the
Required Currency (i) shall not be discharged or satisfied by any tender, any recovery pursuant to any judgment (whether or not entered in accordance with subsection (a)), in any currency other than the Required Currency, except to the extent
that such tender or recovery shall result in the actual receipt, by the payee, of the full amount of the Required Currency expressed to be payable in respect of such payments, (ii) shall be enforceable as an alternative or additional cause of
action for the purpose of recovering in the Required Currency the amount, if any, by which such actual receipt shall fall short of the full amount of the Required Currency so expressed to be payable, and (iii) shall not be affected by judgment
being obtained for any other sum due under this Indenture. For purposes of the foregoing, “New York Banking Day” means any day except a Saturday, Sunday or a legal holiday in The City of New York on which banking institutions are
authorized or required by law, regulation or executive order to close. 
 Section 10.17. Force Majeure.

 In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its
obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services, it being understood that the Trustee shall use reasonable best efforts which are consistent with accepted
practices in the banking industry to resume performance as soon as practicable under the circumstances. 

  
 43 

 Section 10.18. Waiver of Jury Trial. 

EACH OF THE COMPANY AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND
ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTION CONTEMPLATED HEREBY. 
 ARTICLE XI. 
 SINKING FUNDS 

Section 11.1. Applicability of Article. 

The provisions of this Article shall be applicable to any sinking fund for the retirement of the Securities of a Series if
so provided by the terms of such Securities pursuant to Section 2.2 and except as otherwise permitted or required by any form of Security of such Series issued pursuant to this Indenture. 

The minimum amount of any sinking fund payment provided for by the terms of the Securities of any Series is herein
referred to as a “mandatory sinking fund payment” and any other amount provided for by the terms of Securities of such Series is herein referred to as an “optional sinking fund payment.” If provided for by the terms
of Securities of any Series, the cash amount of any sinking fund payment may be subject to reduction as provided in Section 11.2. Each sinking fund payment shall be applied to the redemption of Securities of any Series as provided for by the
terms of the Securities of such Series. 
 Section 11.2. Satisfaction of Sinking Fund Payments with
Securities. 
 The Company may, in satisfaction of all or any part of any sinking fund payment with respect
to the Securities of any Series to be made pursuant to the terms of such Securities (1) deliver outstanding Securities of such Series to which such sinking fund payment is applicable (other than any of such Securities previously called for
mandatory sinking fund redemption) and (2) apply as credit Securities of such Series to which such sinking fund payment is applicable and which have been repurchased by the Company or redeemed either at the election of the Company pursuant to
the terms of such Series of Securities (except pursuant to any mandatory sinking fund) or through the application of permitted optional sinking fund payments or other optional redemptions pursuant to the terms of such Securities, provided that such
Securities have not been previously so credited. Such Securities shall be received by the Trustee, together with an Officer’s Certificate with respect thereto, not later than 15 days prior to the date on which the Trustee begins the process of
selecting Securities for redemption, and shall be credited for such purpose by the Trustee at the price specified in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced
accordingly. If as a result of the delivery or credit of Securities in lieu of cash payments pursuant to this Section 11.2, the principal amount of Securities of such Series to be redeemed in order to exhaust the aforesaid cash payment shall be
less than $100,000, the Trustee need not call Securities of such Series for redemption, except upon receipt of a Company Order that such action be taken, and such cash payment shall be held by the Trustee or a Paying Agent

  
 44 

 
and applied to the next succeeding sinking fund payment, provided, however, that the Trustee or such Paying Agent shall from time to time upon receipt of a Company Order pay over
and deliver to the Company any cash payment so being held by the Trustee or such Paying Agent upon delivery by the Company to the Trustee of Securities of that Series purchased by the Company having an unpaid principal amount equal to the cash
payment required to be released to the Company. 
 Section 11.3. Redemption of Securities for
Sinking Fund. 
 Not less than 45 days (unless otherwise indicated in the Board Resolution, supplemental
indenture hereto or Officer’s Certificate in respect of a particular Series of Securities) prior to each sinking fund payment date for any Series of Securities, the Company will deliver to the Trustee an Officer’s Certificate specifying
the amount of the next ensuing mandatory sinking fund payment for that Series pursuant to the terms of that Series, the portion thereof, if any, which is to be satisfied by payment of cash and the portion thereof, if any, which is to be satisfied by
delivering and crediting of Securities of that Series pursuant to Section 11.2, and the optional amount, if any, to be added in cash to the next ensuing mandatory sinking fund payment, and the Company shall thereupon be obligated to pay the
amount therein specified. Not less than 30 days (unless otherwise indicated in the Board Resolution, Officer’s Certificate or supplemental indenture in respect of a particular Series of Securities) before each such sinking fund payment date the
Trustee shall select the Securities to be redeemed upon such sinking fund payment date in the manner specified in Section 3.2 and cause notice of the redemption thereof to be given in the name of and at the expense of the Company in the manner
provided in Section 3.3. Such notice having been duly given, the redemption of such Securities shall be made upon the terms and in the manner stated in Sections 3.4, 3.5 and 3.6. 

  
 45 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly
executed as of the day and year first above written. 
  

			
	 InterMune, Inc.

		
	 By:
	 	 /s/ John C. Hodgman

		 	 Name: John C. Hodgman

		 	 Its: SVP & CFO

	
	 The Bank of New York Mellon Trust Company, N.A., as Trustee

		
	 By:
	 	 /s/ Alex Briffett

		 	 Name: John A. (Alex) Briffett

		 	 Its: Senior AssociateFirst Supplemental Indenture

 Exhibit 4.2 

 
  
  

INTERMUNE, INC. 

as Issuer 
 AND

 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. 
 as Trustee 
  

 
 First
Supplemental Indenture 
 Dated as of September 19, 2011 

to 

Indenture dated as of September 19, 2011 

 
  

2.50% Convertible Senior Notes due 2018 
  

 

 TABLE OF CONTENTS 

 
  

 

					
		  	PAGE
	 ARTICLE 1
 CERTAIN DEFINITIONS AND PROVISIONS OF GENERAL APPLICATION

 

	Section 1.01 . Definitions	  	2
	Section 1.02 . Conflicts With Base Indenture	  	7
	Section 1.03 . Section References	  	7
	  
 ARTICLE 2

THE NOTES

 
	  	
	Section 2.01 . Designation and Terms of Notes	  	7
	Section 2.02 . Denominations	  	7
	Section 2.03 . Form and Dating	  	7
	Section 2.04 . Conversion Agent	  	9
	Section 2.05 . [reserved]	  	9
	Section 2.06 . Ranking	  	9
	Section 2.07 . Further Issues; Repurchases	  	9
	  
 ARTICLE 3

PARTICULAR COVENANTS OF THE COMPANY

 
	  	
	Section 3.01 . Payment of Principal and Interest	  	10
	Section 3.02 . [reserved]	  	10
	Section 3.03 . [reserved]	  	11
	Section 3.04 . Provisions as to Paying Agent	  	11
	Section 3.05 . [reserved]	  	12
	Section 3.06 . SEC Filings and Reports	  	12
	Section 3.07 . [reserved]	  	12
	Section 3.08 . Additional Interest	  	12
	  
 ARTICLE 4

REPURCHASE AT OPTION OF THE HOLDER

 
	  	
	Section 4.01 . Repurchase at the Option of the Holder Upon a Fundamental Change	  	13
	  
 ARTICLE 5

CONVERSION OF NOTES

 
	  	
	Section 5.01 . Right to Convert	  	17
	Section 5.02 . Conversion Procedures	  	17

  
 i 

					
	Section 5.03 . Settlement Upon Conversion	  	18
	Section 5.04 . [reserved]	  	20
	Section 5.05 . Adjustment of Conversion Rate	  	20
	Section 5.06 . Recapitalizations, Reclassifications and Changes of Shares of Common Stock	  	29
	Section 5.07 . Adjustments of Prices	  	29
	Section 5.08 . Adjustment to Shares Delivered Upon Conversion Upon Make-Whole Fundamental Changes	  	30
	Section 5.09 . Taxes on Shares Issued	  	31
	 Section 5.10 . Reservation of Shares; Shares to be Fully Paid; Compliance with Governmental

            Requirements
	  	32
	Section 5.11 . Responsibility of Trustee	  	32
	Section 5.12 . [reserved]	  	32
	Section 5.13 . Stockholder Rights Plan	  	32
	Section 5.14 . Company Determination Final	  	33
	  
 ARTICLE 6

REDEMPTION

 
	  	
	Section 6.01 . Optional Redemption.	  	33
	Section 6.02 . Right to Redeem; Notices to Trustee.	  	33
	Section 6.03 . Selection of Notes to be Redeemed	  	34
	Section 6.04 . Notice of Redemption	  	34
	Section 6.05 . Effect of Notice of Redemption	  	35
	Section 6.06 . Deposit of Redemption Price	  	35
	Section 6.07 . Notes Redeemed in Part	  	35
	Section 6.08 . Payment of Interest Upon Redemption	  	36
	Section 6.09 . Transfer and Exchange Upon Redemption	  	36
	Section 6.10 . Effect of Acceleration	  	36
	  
 ARTICLE 7

REMEDIES

 
	  	
	Section 7.01 . Events of Default	  	36
	Section 7.02 . Acceleration of Maturity; Rescission and Annulment	  	38
	Section 7.03 . Collection of Indebtedness and Suits for Enforcement by Trustee	  	39
	Section 7.04 . Trustee May File Proofs of Claim	  	40
	Section 7.05 . Trustee May Enforce Claims Without Possession of Notes	  	40
	Section 7.06 . Application of Money Collected	  	40
	Section 7.07 . Limitation on Suits	  	41
	Section 7.08 . Unconditional Right of Holders to Receive Principal and Interest and to Convert	  	41
	Section 7.09 . Restoration of Rights and Remedies	  	42
	Section 7.10 . Rights and Remedies Cumulative	  	42
	Section 7.11 . Delay or Omission Not Waiver	  	42

  
 ii 

					
	Section 7.12 . Control by Holders	  	42
	Section 7.13 . Waiver of Past Defaults and Rescission	  	43
	Section 7.14 . Undertaking for Costs	  	43
	Section 7.15 . [reserved]	  	44
	Section 7.16 . Notice of Default	  	44
	Section 7.17 . Interest on Overdue Payments	  	44
	  
 ARTICLE 8

CONSOLIDATION, MERGER, CONVEYANCE, TRANSFER OR
LEASE
  
	  	
	Section 8.01 . Company May Consolidate, Etc., Only on Certain Terms	  	44
	Section 8.02 . Successor Substituted	  	45
	  
 ARTICLE 9

SATISFACTION AND DISCHARGE

 
	  	
	Section 9.01 . Satisfaction and Discharge of Indenture	  	45
	  
 ARTICLE 10

SUPPLEMENTAL INDENTURES
  
	  	
	Section 10.01 . Supplemental Indentures	  	46
	Section 10.02 . Supplemental Indentures Without Consent of Holders	  	46
	Section 10.03 . Supplemental Indentures with Consent of Holders	  	47
	Section 10.04 . Notices of Supplemental Indentures	  	49
	  
 ARTICLE 11

MISCELLANEOUS

 
	  	
	Section 11.01 . Governing Law	  	49
	Section 11.02 . Calculations in Respect of Notes	  	49
	Section 11.03 . No Representations or Warranties by the Trustee	  	49

 Signatures 

Schedule A 
 Exhibit A 

  
 iii

 FIRST SUPPLEMENTAL INDENTURE, dated as of September 19, 2011 (“Supplemental
Indenture”), to the Indenture dated as of September 19, 2011 (as amended, modified or supplemented from time to time in accordance therewith, the “Base Indenture” and, as amended, modified and supplemented by this
Supplemental Indenture, the “Indenture”), by and among INTERMUNE, INC., a Delaware corporation (the “Company”) and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as trustee (the “Trustee”).

 RECITALS OF THE COMPANY 
 WHEREAS, the Company has duly authorized the execution and delivery of the Base Indenture to provide for the issuance from time to time of debt securities (the “Securities”) to be issued
in one or more series as provided in the Base Indenture; 
 WHEREAS, Section 2.1 of the Base Indenture provides for the
Company to establish Securities of any series pursuant to a supplemental indenture, and Section 9.1(e) of the Base Indenture provides for the Company and the Trustee to enter into any such supplemental indenture to provide for the issuance and
establish the form or terms of Securities of such series as permitted by Section 2.1 of the Indenture without the consent of any Holders; 
 WHEREAS, the Board of Directors has duly adopted resolutions authorizing the Company to execute and deliver this Supplemental Indenture; 

WHEREAS, pursuant to the terms of the Indenture, the Company desires to provide for the establishment of a new series of its Securities
to be known as its “2.50% Convertible Senior Notes due 2018” (the “Notes”), the form and substance of the Notes and the terms, provisions and conditions thereof to be set forth as provided in the Indenture; and 

WHEREAS, the Company has requested that the Trustee execute and deliver this Supplemental Indenture, and all requirements necessary to
make (i) this Supplemental Indenture a valid and legally binding instrument in accordance with its terms and (ii) the Notes, when executed by the Company and authenticated and delivered by the Trustee, the valid and legally binding
obligations of the Company, have been performed, and the execution and delivery of this Supplemental Indenture has been duly authorized in all respects. 
 NOW, THEREFORE, THIS SUPPLEMENTAL INDENTURE WITNESSETH, for and in consideration of the premises and the purchases of the Notes by the Holders thereof, it is mutually agreed, for the benefit of the
Company and the equal and proportionate benefit of all Holders of the Notes, as follows: 

 ARTICLE 1 
 CERTAIN DEFINITIONS AND PROVISIONS OF GENERAL APPLICATION 

Section 1.01. Definitions. Capitalized terms used herein and not otherwise defined herein have the meanings assigned to them
in the Base Indenture. 
 As used herein, the following terms have the specified meanings: 

“Act” means any request, demand, authorization, direction, notice, consent, waiver or other action provided by this
Indenture to be given or taken by Holders that may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such Holders in person or by their agents duly appointed in writing. 

“Additional Interest” has the meaning specified in 0. 

“Additional Notes” means an unlimited maximum aggregate principal amount of Notes (other than the Initial Notes) issued
under this Supplemental Indenture. 
 “Additional Shares” has the meaning specified in Section 5.08(a).

 “Applicable Procedures” with respect to any transfer or transaction involving a Global Note or beneficial
interest therein, the rules and procedures of DTC or any successor Depositary, in each case to the extent applicable to such transaction and as in effect from time to time. 
 “Close of Business” means 5:00 p.m. New York City time. 

“Common Equity” of any corporation means the common stock, common equity interests, ordinary shares or depositary shares
or other certificates representing common equity interests of such corporation. 
 “Common Stock” means the
shares of common stock, par value $0.001 per share, of the Company as they exist on the date of this Supplemental Indenture or any other shares of Capital Stock of the Company into which the Common Stock shall be reclassified or changed or, in the
event of a merger, consolidation or other similar transaction involving the Company that is otherwise permitted hereunder in which the Company is not the surviving corporation, the Common Equity of such surviving corporation or its direct or
indirect parent corporation. 
 “Conversion Agent” has the meaning specified in Section 2.04. 

“Conversion Date” has the meaning specified in Section 5.02. 

“Conversion Notice” has the meaning specified in Section 5.02. 

  
 2 

 “Conversion Price” means at any time the amount equal to $1,000 divided by
the then applicable Conversion Rate. 
 “Conversion Rate” has the meaning specified in Section 5.01.

 “corporation” means a corporation, association, company, joint-stock company or business trust. 

“Depositary” has the meaning specified in Section 2.03(b). 

“DTC” means The Depository Trust Company, a New York corporation, or any successor. 

“Effective Date” means the date on which a Make-Whole Fundamental Change occurs or becomes effective. 

“Event of Default” has the meaning specified in Section 7.01. 

“Ex-Dividend Date” means the first date on which the shares of the Common Stock trade on the relevant exchange or in the
relevant market, regular way, without the right to receive such issuance, dividend or distribution in question from the Company or, if applicable, from the seller of the Common Stock on such exchange or market (in the form of due bills or otherwise)
as determined by such exchange or market. 
 “Expiration Date” has the meaning specified in
Section 5.05(e). 
 “Fundamental Change” will be deemed to have occurred at the time after the Notes are
originally issued of any of the following occurs: 
 (1) any “person” or “group” within the meaning of
Section 13(d) of the Exchange Act other than the Company, its Subsidiaries and its and their employee benefit plans, files a Schedule TO or any schedule, form or report under the Exchange Act disclosing, or the Company otherwise becomes aware,
that such person or group has become the direct or indirect “beneficial owner,” as defined in Rule 13d-3 under the Exchange Act, of the Company’s Common Equity representing more than 50% of the voting power of the Company’s
Common Equity; 
 (2) the consummation of (A) any recapitalization, reclassification or change of the Common Stock (other
than changes resulting from a subdivision or combination) as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, other property or assets; (B) any share exchange, consolidation or merger of the
Company pursuant to which the Common Stock will be converted into cash, securities or other property; or (C) any sale, lease or other transfer in one transaction or a series of transactions of all or substantially all of the consolidated assets
of the Company and its Subsidiaries, 

  
 3 

 
taken as a whole, to any person other than one of the Company’s Subsidiaries; provided, however, that a transaction described in clause (A) or (B) in which the
holders of all classes of the Company’s Common Equity immediately prior to such transaction own, directly or indirectly, more than 50% of all classes of the Company’s Common Equity of the continuing or surviving corporation or transferee
or the parent thereof immediately after such transaction in substantially the same proportions (relative to each other) as such ownership immediately prior to such transaction shall not be a Fundamental Change pursuant to this clause (2);

 (3) the Company’s stockholders approve any plan or proposal for its liquidation or dissolution; or 

(4) the Common Stock (or other common stock or common equity interests underlying the Notes) ceases to be listed or quoted on any of The
New York Stock Exchange, The NASDAQ Global Select Market or The NASDAQ Global Market (or any of their respective successors). 
 A transaction
or transactions described in clauses (1) or (2) above will not constitute a Fundamental Change, however, if at least 90% of the consideration received or to be received by holders of the Common Stock, excluding cash payments for fractional
shares and cash payments made pursuant to dissenters’ appraisal rights, in connection with such transaction or transactions consists of shares of common stock or common equity interests listed or quoted on any of The New York Stock Exchange,
The NASDAQ Global Select Market or The NASDAQ Global Market or (or any of their respective successors) or will be so listed or quoted when issued or exchanged in connection with such transaction or transactions and as a result of such transaction or
transactions the Notes become convertible into such consideration, excluding cash payments for fractional shares and cash payments made pursuant to dissenters’ appraisal rights, pursuant to this Indenture. 

“Fundamental Change Expiration Time” has the meaning specified in Section 4.01(c). 

“Fundamental Change Repurchase Date” has the meaning specified in Section 4.01(a). 

“Fundamental Change Repurchase Notice” has the meaning specified in Section 4.01(a). 

“Fundamental Change Repurchase Price” has the meaning specified in Section 4.01(a). 

“Fundamental Change Repurchase Right Notice” has the meaning specified in Section 4.01(b). 

“Global Note” means a Note that is a Global Security. 

  
 4 

 “Initial Notes” has the meaning specified in Section 2.01. 

“Interest Payment Date” means each March 15 and September 15 of each year, beginning March 15, 2012.

 “Last Reported Sale Price” of the Common Stock on any date means the closing per-share sale price (or if no
closing per-share sale price is reported, the average of the last bid and ask prices or, if more than one in either case, the average of the average last bid and the average last ask prices) on that date as reported in composite transactions on
principal U.S. national securities exchange or market on which the Common Stock is listed or admitted for trading. If the Common Stock is not so listed or admitted for trading, the “Last Reported Sale Price” of the Common Stock will be the
last quoted bid price per share of the Common Stock in the over-the-counter market on the relevant Trading Day as reported by OTC Markets Group Inc. or another similar organization selected by the Company. If the Common Stock is not so quoted, the
“Last Reported Sale Price” of the Common Stock will be the average of the midpoint of the last bid and ask prices for shares of the Common Stock on the relevant date from each of at least three nationally recognized independent investment
banking firms selected by the Company for this purpose. 
 “Make-Whole Fundamental Change” means any
transaction or event that constitutes a Fundamental Change, after giving effect to any exceptions or exclusions under the definition of Fundamental Change, but without regard to the proviso in clause (2) under the definition of Fundamental
Change. 
 “Market Disruption Event” means the occurrence or existence on any Scheduled Trading Day of any
suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted by the stock exchange or otherwise) in the Common Stock or in any options, contracts or futures contracts relating to the Common Stock, and such
suspension or limitation occurs or exists at any time within the 30 minutes prior to the closing time of the relevant exchange on such day. 
 “Merger Event” has the meaning specified in Section 5.06. 

“Note” and “Notes” have the meaning specified in the Recitals and include the Initial Notes and any
Additional Notes. The Initial Notes and Additional Notes shall be treated as a single class for all purposes under this Indenture. 
 “Notice of Redemption” has the meaning specified in Section 6.04. 
 “Open of Business” means 9:00 a.m. New York City time. 

“Record Date” means, with respect to any dividend, distribution or other transaction or event in which the holders of
the Common Stock have the right to 

  
 5 

 
receive any cash, securities or other property or in which Common Stock (or other applicable security) is exchanged for or converted into any combination of cash, securities or other property,
the date fixed for determination of holders of the Common Stock entitled to receive such cash, securities or other property (whether such date is fixed by the Board of Directors, statute, contract or otherwise). 

“Redemption Date” means, with respect to any Notes, the date specified for redemption of such Notes in accordance with
the terms of the Notes and Article 6. 
 “Redemption Price” has the meaning specified in Section 6.02(b).

 “Reference Property” has the meaning specified in Section 5.06. 

“Regular Record Date” has the meaning specified in Section 3.01(b). 

“Reporting Event of Default” has the meaning specified in 0. 

“Scheduled Trading Day” means a day that is scheduled to be a Trading Day on the principal U.S. national securities
exchange or market on which the Common Stock is listed or admitted for trading. If the Common Stock is not so listed or admitted for trading, “Scheduled Trading Day” means a Business Day. 

“Securities Act” means the Securities Act of 1933, as amended. 

“Securities Custodian” means the Trustee, as custodian with respect to the Global Note, or any successor thereto.

 “Significant Subsidiaries” means a subsidiary that is a “significant subsidiary”
as defined under Rule 1-02(w) of Regulation S-X under the Exchange Act; provided that, in the case of a subsidiary that meets the criteria of clause (3) of the definition thereof but not clause (1) or (2) thereof, such subsidiary
shall not be deemed to be a Significant Subsidiary unless the subsidiary’s income from continuing operations before income taxes, extraordinary items and cumulative effect of a change in accounting principle exclusive of amounts attributable to
any non-controlling interests for the last completed fiscal year prior to the date of such determination exceeds $35,000,000. 

“Spin-Off” has the meaning specified in Section 5.05(c)(iii). 

“Stated Maturity”, with respect to the Notes, means September 15, 2018. 

“Stock Price” has the meaning specified in Section 5.08(b). 

“Trading Day” means a day during which (i) trading in the Common Stock generally occurs on a U.S. national
securities exchange and (ii) there is no Market Disruption Event. If the Common Stock is not so traded, “Trading Day” means a Business Day. 

  
 6 

 “Valuation Period” has the meaning specified in Section 5.05(c).

 Section 1.02. Conflicts With Base Indenture. If any provision of this Supplemental Indenture limits, qualifies
or conflicts with a provision of the Base Indenture, such provision of this Supplemental Indenture shall control. 

Section 1.03. Section References. References to Articles, Sections, Exhibits, Annexes and Schedules are to Articles,
Sections, Exhibits, Annexes and Schedules of this Supplemental Indenture unless otherwise specified. 
 ARTICLE 2

 THE NOTES 
 Section 2.01. Designation and Terms of Notes. There is hereby created and designated a series of Securities under the Base Indenture: the title of the Notes shall be “2.50% Convertible
Senior Notes Due 2018.” The changes, modifications and supplements to the Base Indenture effected by this Supplemental Indenture shall be applicable only with respect to, and govern the terms of, the Notes and shall not apply to any other
series of Securities that may be issued under the Base Indenture unless a supplemental indenture with respect to such other series of Securities specifically incorporates such changes, modifications and supplements. 

The aggregate principal amount of the Notes that initially may be authenticated and delivered under this Supplemental Indenture (the
“Initial Notes”) shall be limited to $155,250,000, subject to increase as set forth in Section 10.02(d)2.07. 
 The Notes shall mature on September 15, 2018. 
 Principal and interest
(including Additional Interest, if any) on Global Notes shall be payable in the manner set forth in Section 3.01. 
 The
Notes shall be convertible as provided in Article 5. 
 Section 2.02. Denominations. The Notes shall be issuable
only in book-entry form without coupons and only in denominations of $1,000 and any integral multiple thereof. 

Section 2.03. Form and Dating. (a) The Notes and the corresponding Trustee’s certificate of authentication shall
be substantially in the respective forms set forth in Exhibit A, which Exhibit is incorporated in and made part of this Indenture. The Notes may have notations, legends or endorsements required by law, exchange rule, Applicable Procedures or
usage. The Company shall provide any such notations, legends or endorsements to the Trustee in writing. Each Note shall be dated the date of its authentication. 

  
 7 

 (b) Global Notes. 

(i) All of the Notes shall be issued initially in the form of one or more Global Notes, which shall be deposited on
behalf of the purchasers of the Notes represented thereby with the Trustee, at its Corporate Trust Office, as custodian for the depositary, The Depository Trust Company (such depositary, or any successor thereto, being hereinafter referred to as the
“Depositary”), and registered in the name of its nominee, Cede & Co., or as otherwise instructed by the Depositary duly executed by the Company and authenticated by the Trustee as hereinafter provided. A Global Note may be
transferred, in whole or in part, only to another nominee of the Depositary or to a successor of the Depositary or its nominee. Beneficial interest in a global note may be held directly through the Depositary if such Holder is a participant in the
Depositary, or directly through organizations that are participants in the Depositary. Transfers between participants shall be effected in the ordinary way in accordance with Applicable Procedures and shall be settled in clearing house funds. The
aggregate principal amount of the Global Notes may from time to time be increased or decreased by adjustments made on the records of the Securities Custodian and the Depositary as hereinafter provided, subject in each case to compliance with the
Applicable Procedures and the provisions of this Indenture. 
 (ii) Each Global Note shall represent such of the
outstanding Notes as shall be specified therein and each shall provide that it shall represent the aggregate amount of outstanding Notes from time to time endorsed thereon and that the aggregate amount of outstanding Notes represented thereby may
from time to time be reduced or increased, as appropriate, to reflect exchanges, purchases or conversions of such Notes. Any adjustment of the aggregate principal amount of a Global Note to reflect the amount of any increase or decrease in the
amount of outstanding Notes represented thereby shall be made by the Trustee in accordance with Applicable Procedures and shall be made on the records of the Trustee and the Depositary. 

(c) Certificated Notes. Notwithstanding anything to the contrary in Section 2.14.2 of the Base Indenture, beneficial
interests in a Global Note may be exchanged for certificated Notes: 
 (i) If (x) the Depositary for such
Global Note notifies the Company that it is unwilling or unable to continue as Depositary for such Global Note or if at any time such Depositary ceases to be a clearing agency registered under the Exchange Act, and, in either case, the Company fails
to appoint a successor Depositary registered as a clearing agency under the Exchange Act within 90 days of such event or (y) the Company executes and delivers to the Trustee an Officer’s Certificate to the effect that such Global Note
shall be so exchangeable; 

  
 8 

 (ii) If an Event of Default has occurred and is continuing; or 

(iii) If the holder of such beneficial interest and the Company agree to such exchange. 

Section 2.04. Conversion Agent. The Company shall maintain an office or agency where Notes may be presented for conversion
(the “Conversion Agent”). The Company will give prompt written notice to the Trustee of the name and address, and any change in the name or address, of the Conversion Agent. If at any time the Company shall fail to maintain the
Conversion Agent or shall fail to furnish the Trustee with the name and address thereof, such presentations, surrenders, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the
Trustee as its agent to receive all such presentations, surrenders, notices and demands. 
 The Company hereby initially
appoints the Trustee as Registrar, Paying Agent and Conversion Agent in connection with the Notes. 
 Section 2.05.
[reserved].  
 Section 2.06. Ranking. The obligations of the Company arising under or in connection with this
Indenture and every outstanding Note issued under this Indenture from time to time constitute and shall constitute a general unsecured senior obligation of the Company, ranking equally with existing and future senior unsecured indebtedness of the
Company and ranking senior in right of payment to any future indebtedness of the Company that is expressly made subordinate to the Notes by the terms of such indebtedness. 
 Section 2.07. Further Issues; Repurchases. The Company may, without the consent of the Holders, issue Additional Notes in an unlimited aggregate principal amount under the Indenture with the
same terms as the Initial Notes; provided, that if the Additional Notes are not fungible with the Initial Notes for United States federal income tax purposes, the Additional Notes will have a separate CUSIP number. Any such Additional
Notes will, for all purposes of the Indenture, including waivers, amendments and offers to purchase, be treated as part of the same series as the Initial Notes. In addition, without prior notice to Holders, the Company may, to the extent permitted
by law, and directly or indirectly (regardless of whether such Notes are surrendered to the Company), repurchase Notes in the open market or otherwise, whether by the Company or its Subsidiaries or through a private or public tender or exchange
offer or through counterparties to private agreements, including by cash-settled swaps or other derivatives. 

  
 9 

 ARTICLE 3 
 PARTICULAR COVENANTS OF THE COMPANY 
 Subject to Section 1.02 hereof, the provisions of Article IV of the Base Indenture, as supplemented by the provisions of this Supplemental Indenture, shall apply to the Notes. 

Section 3.01. Payment of Principal and Interest. The Company covenants and agrees that it shall duly and punctually pay or
cause to be paid the principal of and interest (including Additional Interest, if any), on each of the Notes at the places, at the respective times and in the manner provided herein and in the Notes. 

(a) The Notes will bear interest at a rate of 2.50% per year. Interest on the Notes will accrue from and including the date of
issuance, or from the most recent date to which interest has been paid or duly provided for. Interest will be payable semiannually in arrears on each Interest Payment Date beginning March 15, 2012. Pursuant to Section 7.02 of this
Indenture, in certain circumstances, the Holders of Notes shall be entitled to receive Additional Interest. 
 (b) Interest
(including Additional Interest, if any) will be paid to the person in whose name a Note is registered at the Close of Business on March 1 or September 1, as the case may be (the “Regular Record Date”), immediately
preceding the relevant Interest Payment Date. Interest on the Notes will be computed on the basis of a 360-day year composed of twelve 30-day months. 
 (c) Method of Payment. The Company will pay the principal of certificated Notes at the office or agency designated by the Company. The Company has initially designated a Corporate Trust Office of
the Trustee as its Paying Agent and Registrar as a place where Notes may be presented for payment for or registration of transfer. The Company will pay any interest on any certificated Note to the Holder of such Note (i) if such Holder holds
$2,000,000 or less aggregate principal amount of Notes, by check mailed to such Holder’s registered address, and (ii) if such Holder holds more than $2,000,000 aggregate principal amount of Notes, (A) by check mailed to such
Holder’s registered address or, (B) if such Holder delivers to the Registrar a written request that the Company make such payments by wire transfer to an account of such Holder within the United States, for each interest payment
corresponding to each Regular Record Date occurring during the period beginning on the date on which such Holder delivered such request and ending on the date, if any, on which such Holder delivers to the Registrar a written instruction to the
contrary, by wire transfer of immediately available funds to the account specified by such Holder. 
 The Company shall pay the
principal of, and interest on Global Notes in immediately available funds to the Depositary. 
 Section 3.02.
[reserved]. 

  
 10 

 Section 3.03. [reserved]. 

Section 3.04. Provisions as to Paying Agent.  
 (a) If the Company shall appoint a Paying Agent other than the Trustee, or if the Trustee shall appoint such a Paying Agent, the Company will cause such Paying Agent to execute and deliver to the Trustee
an instrument in which such Paying Agent shall agree with the Trustee, subject to the provisions of this Section 3.04 that such Paying Agent will: 
 (i) comply with the duties applicable to a paying agent under the TIA; and 
 (ii) during the continuance of any Default by the Company (or any other obligor upon the Notes) in the making of any payment in respect of the Notes, upon the written request of the Trustee, forthwith pay
to the Trustee all sums held in trust by such Paying Agent as such. 
 This paragraph replaces Section 4.1 of the Base
Indenture with respect to the Notes in its entirety. The Company shall, on or before each due date of the principal of (excluding any Redemption Price or Fundamental Change Repurchase Price with respect to), or interest (including Additional
Interest, if any) on, the Notes, deposit with the Paying Agent a sum (in funds which are immediately available on the due date for such payment) sufficient to pay such principal or interest, and (unless such Paying Agent is the Trustee) the Company
will promptly notify the Trustee of any failure to take such action; provided, however, that if such deposit is made on the due date, such deposit shall be received by the Paying Agent by 11:00 a.m. New York City time, on such date.

 (b) If the Company shall act as its own Paying Agent, it will, on or before each due date of the principal of or interest on
the Notes, set aside, segregate and hold in trust for the benefit of the Holders of the Notes a sum sufficient to pay such principal or interest (including Additional Interest, if any) so becoming due and will promptly notify the Trustee of any
failure to take such action and of any failure by the Company (or any other obligor under the Notes) to make any payment of the principal of or interest (including Additional Interest, if any) on the Notes when the same shall become due and payable.

 (c) Anything in this Section 3.04 to the contrary notwithstanding, the Company may, at any time, for the purpose of
obtaining a satisfaction and discharge of this Indenture, or for any other reason, pay or cause to be paid to the Trustee all sums held in trust by the Company or any Paying Agent hereunder as required by this Section 3.04, such sums to be held
by the Trustee upon the trusts herein contained, and upon such payment by the Company or any Paying Agent to the Trustee, the Company or such Paying Agent shall be released from all further liability with respect to such sums. 

  
 11 

 (d) Anything in this Section 3.04 to the contrary notwithstanding, the agreement to
hold sums in trust as provided in this Section 3.04 is subject to Section 8.5 of the Base Indenture. 
 The Trustee
shall not be responsible for the actions of any other Paying Agents (including the Company if acting as its own Paying Agent) and shall have no control of any funds held by such other Paying Agents. 

Section 3.05. [reserved]. 
 Section 3.06. SEC Filings and Reports. This Section 3.06 replaces Section 4.2 of the Base Indenture with respect to the Notes in its entirety. The Company covenants that any
documents or reports that the Company is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act shall be filed by the Company with the Trustee within 15 calendar days after the same are required to be filed with the
SEC (giving effect to any grace period provided by Rule 12b-25 under the Exchange Act). Documents filed by the Company pursuant to the SEC’s “EDGAR” system (or any successor electronic filing system) shall be deemed to constitute
“filing” with the Trustee for purposes of this Section 3.06. If at any time the Company is not subject to the reporting requirements of Section 13 or 15(d) of the Exchange Act, the Company shall provide the Trustee and the
Holders with annual and quarterly reports containing substantially the same information as would have been required to be filed with the SEC had the Company continued to have been subject to such reporting requirements. In such event, such annual
and quarterly reports shall be provided at the times the Company would have been required to provide reports had it continued to have been subject to such reporting requirements. Delivery of such reports, information and documents to the Trustee is
for informational purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Company’s compliance with any
of its covenants hereunder (as to which the Trustee is entitled to rely exclusively on Officers’ Certificates). 

Section 3.07. [reserved]. 
 Section 3.08. Additional Interest. If at any time Additional Interest becomes payable by the Company pursuant to Section 7.02, the Company shall promptly deliver to the Trustee a
certificate to that effect and stating (i) the amount of such Additional Interest that is payable and (ii) the date on which such Additional Interest is payable. Unless and until a Responsible Officer of the Trustee receives such a
certificate, the Trustee may assume without inquiry that no Additional Interest is payable. If the Company has paid Additional Interest directly to the Persons entitled to such Additional Interest, the Company shall deliver to the Trustee a
certificate setting forth the particulars of such payment. 

  
 12 

 ARTICLE 4 
 REPURCHASE AT OPTION OF THE HOLDER 

Section 4.01. Repurchase at the Option of the Holder Upon a Fundamental Change.  

(a) If a Fundamental Change occurs at any time, the Holders shall have the right, at such Holder’s option, to require the Company to
repurchase all of such Holder’s Notes, or any portion of the principal amount thereof that is equal to $1,000 or an integral multiple of $1,000, on a date (the “Fundamental Change Repurchase Date”) specified by the Company that
is not less than 20 Business Days and not more than 35 Business Days after the date of the Fundamental Change Repurchase Right Notice at a repurchase price equal to 100% of the principal amount of the Notes to be repurchased plus accrued and unpaid
interest, if any, to, but excluding, the Fundamental Change Repurchase Date, unless such Fundamental Change Repurchase Date falls after a Regular Record Date for an Interest Payment Date and on or prior to the corresponding Interest Payment Date, in
which case the Company will pay the full amount of accrued and unpaid interest payable on such Interest Payment Date to the Holder of record at the Close of Business on such Regular Record Date (the “Fundamental Change Repurchase
Price”). Any notes repurchased by the Company will be paid for in cash. 
 Repurchases of Notes under this
Section 4.01 shall be made, at the option of the Holder thereof, upon: 
 (i) if the Notes are held in
certificated form, delivery to the Trustee (or other Paying Agent appointed by the Company) by a Holder of a duly completed notice (the “Fundamental Change Repurchase Notice”) in the form set forth on the reverse of the Note or, if
the Notes are Global Notes, a notice that complies with the Applicable Procedures, prior to the Close of Business on the second Scheduled Trading Day immediately preceding the Fundamental Change Repurchase Date, subject to extension to comply with
applicable law; and 
 (ii) delivery or book-entry transfer of the Notes (together with all necessary
endorsements) to the Trustee (or other Paying Agent appointed by the Company) at any time after delivery of the Fundamental Change Repurchase Notice and prior to the Close of Business on the second Scheduled Trading Day immediately preceding the
Fundamental Change Repurchase Date, subject to extension to comply with applicable law, at the Corporate Trust Office of the Trustee (or other Paying Agent appointed by the Company), such delivery being a condition to receipt by the Holder of the
Fundamental Change Repurchase Price therefor; provided that such Fundamental Change Repurchase Price shall be so paid pursuant to this Section 4.01 only if the Note so delivered to the Trustee (or other Paying Agent appointed by the
Company) shall conform in all 

  
 13 

 
respects to the description thereof in the related Fundamental Change Repurchase Notice. 
 The Fundamental Change Repurchase Notice shall state: 
 (A) if
certificated, the certificate numbers of Notes to be delivered for repurchase; 
 (B) the portion of the
principal amount of Notes to be repurchased, which must be $1,000 or an integral multiple thereof; and 
 (C)
that the Notes are to be repurchased by the Company pursuant to the applicable provisions of the Notes and this Indenture. 
 provided,
however, that if the Notes are Global Notes, the Fundamental Change Repurchase Notice must comply with the Applicable Procedures. 
 Any purchase by the Company contemplated pursuant to the provisions of this Section 4.01 shall be consummated by the delivery of the consideration to be received by the Holder in accordance with
Section 4.01(d). 
 The Trustee (or other Paying Agent appointed by the Company) shall promptly notify the Company of the
receipt by it of any Fundamental Change Repurchase Notice or written notice of withdrawal thereof in accordance with the provisions of subsection (c) of this Section 4.01. 

Any certificated Note that is to be repurchased only in part shall be surrendered to the Trustee (with, if the Company or the Trustee so
requires, due endorsement by, or a written instrument of transfer in form satisfactory to the Company and the Trustee duly executed by the Holder thereof or his attorney duly authorized in writing), and the Company shall execute, and the Trustee
shall authenticate and make available for delivery to the Holder of such certificated Note without service charge, a new certificated Note or new certificated Notes, containing identical terms and conditions, each in an authorized denomination in
aggregate principal amount equal to and in exchange for the unrepurchased portion of the principal of the certificated Note so surrendered. 
 (b) After the occurrence of a Fundamental Change, but on or before the
15th day following such occurrence, the Company shall
provide to all Holders and the Trustee and Paying Agent a notice (the “Fundamental Change Repurchase Right Notice”) of the occurrence of such Fundamental Change and of the resulting repurchase right, if any, at the option of the
Holders arising as a result thereof. 
 Each Fundamental Change Repurchase Right Notice shall specify: 

  
 14 

 (i) the events causing the Fundamental Change and whether such Fundamental
Change also constitutes a Make-Whole Fundamental Change; 
 (ii) the date of the Fundamental Change; 

(iii) the last date on which a Holder may exercise its repurchase rights under Section 4.01, if applicable;

 (iv) the Fundamental Change Repurchase Price; 

(v) the Fundamental Change Repurchase Date; 

(vi) the name and address of the Paying Agent and the Conversion Agent, if applicable; 

(vii) that the Notes are eligible to be converted, the applicable Conversion Rate and any adjustments to the applicable
Conversion Rate; 
 (viii) that the Notes with respect to which a Fundamental Change Repurchase Notice has been
delivered by a Holder may be converted only if the Holder withdraws the Fundamental Change Repurchase Notice in accordance with the terms of this Indenture; 
 (ix) that the Holder has the right to withdraw any Notes tendered for repurchase prior to the Close of Business on second Scheduled Trading Day immediately preceding the Fundamental Change Repurchase
Date; and 
 (x) the procedures the Holder must follow to require the Company to purchase its Notes under
Section 4.01, if applicable. 
 No failure of the Company to give the foregoing notices and no defect therein shall limit
the Holders’ repurchase rights or affect the validity of the proceedings for the repurchase of the Notes pursuant to this Section 4.01. 
 (c) A Fundamental Change Repurchase Notice may be withdrawn in whole or in part by means of a written notice of withdrawal delivered to the Paying Agent in accordance with the Fundamental Change
Repurchase Right Notice at any time prior to the Close of Business on the second scheduled Trading Day prior to the Fundamental Change Repurchase Date (the “Fundamental Change Expiration Time”), specifying: 

(i) the principal amount of the withdrawn Notes; 

(ii) if certificated Notes have been issued, the certificate numbers of the withdrawn Notes; and 

  
 15 

 (iii) the principal amount, if any, of such Note that remains subject to the
original Fundamental Change Repurchase Notice, which portion must be in principal amounts of $1,000 or an integral multiple of $1,000; 

provided, however, that if the Notes are Global Notes, the notice must comply with the Applicable Procedures. 

(d) On or prior to 11:00 a.m., New York City time, on the Fundamental Change Repurchase Date, the Company shall deposit with the Trustee
(or other Paying Agent appointed by the Company or if the Company is acting as its own Paying Agent, set aside, segregate and hold in trust) an amount of money sufficient to repurchase on the Fundamental Change Repurchase Date all of the Notes to be
repurchased on such date at the Fundamental Change Repurchase Price. Subject to receipt of funds and/or Notes by the Trustee (or other Paying Agent appointed by the Company), payment for Notes properly surrendered for repurchase (and not withdrawn)
prior to the Fundamental Change Expiration Time shall be made promptly after the later of (x) the Fundamental Change Repurchase Date with respect to such Note (provided the Holder has satisfied the conditions to the payment of the Fundamental
Change Repurchase Price in this Section 4.01), or (y) the time of book-entry transfer or the delivery of such Note to the Trustee (or other Paying Agent appointed by the Company) by the Holder thereof in the manner required by this
Section 4.01 in accordance with the provisions in Section 3.01(c). The Trustee shall, promptly after such payment and upon written demand by the Company, return to the Company any funds in excess of the Fundamental Change Repurchase Price.

 (e) Subject to a Holder’s right to receive interest on the related Interest Payment Date where the Fundamental Change
Repurchase Date, as applicable, falls between a Regular Record Date and the Interest Payment Date to which it relates, if the Trustee (or other Paying Agent appointed by the Company) holds money or securities sufficient to pay the Fundamental Change
Repurchase Price on the Fundamental Change Repurchase Date, then (i) such Notes shall cease to be outstanding and interest shall cease to accrue on such Notes, whether or not book-entry transfer of the Notes is made or whether or not the Notes
are delivered to the Paying Agent, and (ii) all other rights of the Holders of such Notes shall terminate other than the right to receive the Fundamental Change Repurchase Price and previously accrued and unpaid interest, if any, upon delivery
or book-entry transfer of the Notes. 
 (f) No Notes may be repurchased at the option of Holders on any date if the principal
amount of the Notes has been accelerated, and such acceleration has not been rescinded, on or prior to such date (except in the case of an acceleration resulting from a Default by the Company in the payment of the applicable Fundamental Change
Repurchase Price with respect to such Notes). 

  
 16 

 (g) In connection with any repurchase offer upon the occurrence of a Fundamental Change, the
Company shall, if required: 
 (i) comply with the provisions of the tender offer rules under the Exchange Act
that may then be applicable; 
 (ii) file a Schedule TO or any successor or similar schedule, if required, under
the Exchange Act; and 
 (iii) otherwise comply with all federal and state securities laws in connection with
any offer by the Company to repurchase the Notes, 
 in each case, so as to permit the rights and obligations under this Article 4 to be
exercised in the time and in the manner specified in this Indenture. 
 ARTICLE 5 

CONVERSION OF NOTES 
 Section 5.01. Right to Convert. Subject to and upon compliance with the procedures for conversion set forth in this Article 5, a Holder shall have the right, at such Holder’s option, to
convert the principal amount of any such Notes, or any portion of such principal amount which is $1,000 or a multiple thereof, into Common Stock at an initial conversion rate (the “Conversion Rate”) equivalent to 31.4465 shares of
Common Stock per $1,000 principal amount of Notes, subject to adjustment as set forth in Section 5.05, at any time prior to the Close of Business on the second Scheduled Trading Day prior to the Stated Maturity, unless the notes have been
previously redeemed or purchased, only upon satisfaction of the conditions precedent to conversion described in Section 5.02. The number of shares of Common Stock issuable and cash payable, if any, upon conversion of a Note shall be determined
as set forth in Section 5.03. 
 Section 5.02. Conversion Procedures. The following procedures shall apply
to the conversion of Notes: 
 (a) In respect of Notes held in certificated form, a Holder must (i) complete and manually
sign the conversion notice attached to the Note (the “Conversion Notice”), or facsimile of such Conversion Notice; (ii) deliver such Conversion Notice, which is irrevocable, and the Note to the Conversion Agent at the office
maintained by the Conversion Agent for such purpose; (iii) to the extent any shares of Common Stock issuable upon conversion are to be issued in a name other than the Holder’s, furnish endorsements and transfer documents as may be required
by the Conversion Agent or stock transfer agent; (iv) if required pursuant to Section 5.09 below, pay all transfer or similar taxes; and (v) if required pursuant to Section 5.03(c) below, pay funds equal to interest payable on
the next Interest Payment Date to which such Holder is not entitled. 

  
 17 

 (b) In respect of a beneficial interest in a Global Note, a Beneficial Owner must comply
with DTC’s procedures for converting a beneficial interest in a Global Note and, if required pursuant to Section 5.03(c), pay funds equal to interest payable on the next Interest Payment Date to which such Beneficial Owner is not entitled,
and if required, taxes or duties, if any. 
 The date a Holder satisfies the foregoing requirements is the “Conversion
Date” hereunder. 
 If the Company has called any Notes for redemption pursuant to Article 6, Holders may surrender any
Notes so called for conversion at the applicable Conversion Rate at any time prior to the Close of Business on the second Scheduled Trading Day immediately preceding the Redemption Date, unless the Company fail to pay the Redemption Price (in which
case a Holder may convert its Notes so called until the Redemption Price has been paid or duly provided for). 
 No Conversion
Notice with respect to any Notes may be tendered by a Holder thereof if such Holder has also tendered a Fundamental Change Repurchase Notice and not validly withdrawn such Fundamental Change Repurchase Notice in accordance with the applicable
provisions of Section 4.01. A Holder’s right to convert its Notes that are subject to such Fundamental Change Repurchase Notice will terminate at the Close of Business on the second Scheduled Trading Day immediately preceding the relevant
Fundamental Change Repurchase Date. 
 Upon surrender of a certificated Note that is converted in part, the Company shall
execute, and the Trustee or the Authenticating Agent shall authenticate and deliver to the Holder, a new certificated Note in an authorized denomination equal in principal amount to the unconverted portion of the Note surrendered. 

A converting Holder will be deemed to be the record holder of the shares of Common Stock deliverable on conversion as of the Close of
Business on the Conversion Date. 
 Section 5.03. Settlement Upon Conversion. 

(a) Settlement Method. Subject to this Section 5.03, upon any conversion of any Note, the Company shall deliver, on or prior
to the third Trading Day immediately following the Conversion Date, a number of shares of Common Stock equal to (i) (A) the aggregate principal amount of Notes to be converted, divided by (B) $1,000, multiplied by (ii) the
applicable Conversion Rate in effect on the Conversion Date. 
 (b) [reserved]. 

(c) Payment of Interest Upon Conversion. 

  
 18 

 (i) Upon conversion, Holders shall not receive any additional cash payment
or shares of Common Stock for accrued and unpaid interest (including Additional Interest, if any), except as described in Section 5.03(c)(ii). Upon conversion, accrued and unpaid interest (including Additional Interest, if any) to the
Conversion Date is deemed to be paid in full rather than cancelled, extinguished or forfeited. 
 (ii)
Notwithstanding Section 5.03(c)(i), if any Note is converted after the Close of Business on a Regular Record Date, Holders of record of such Note at the Close of Business on such Regular Record Date will receive interest (including Additional
Interest, if any) payable on such Notes on the corresponding Interest Payment Date notwithstanding the conversion. Notes surrendered for conversion during the period from the Close of Business on any Regular Record Date to the Open of Business on
the immediately following Interest Payment Date must be accompanied by funds equal to the amount of interest (including Additional Interest, if any) payable on such Interest Payment Date for the Notes so converted; provided that no such payment need
be made: 
 (A) if the Company has specified a Redemption Date that is after a Regular Record Date and prior to
the second Scheduled Trading Day following the corresponding Interest Payment Date; 
 (B) if the Company has
specified a Fundamental Change Repurchase Date that is after a Regular Record Date and on or prior to the second Scheduled Trading Day following the corresponding Interest Payment Date; 

(C) to the extent of any overdue interest, if any overdue interest exists at the time of conversion with respect to such
Notes; or 
 (D) in respect of any conversions that occur after the Regular Record Date immediately preceding
the Stated Maturity. 
 (d) Cash Payments in Lieu of Fractional Shares. The Company shall not issue fractional shares of
Common Stock upon conversion of the Notes. If multiple Notes shall be surrendered for conversion at one time by the same Holder, the number of full shares of Common Stock which shall be issuable upon conversion (and the number of fractional shares
of Common Stock, if any, for which cash shall be delivered) shall be computed on the basis of the aggregate principal amount of the Notes (or specified portions thereof to the extent permitted hereby) so surrendered. If any fractional share of
Common Stock would be issuable upon the conversion of any Notes, the Company shall make payment an amount in cash for the current market value of the fractional shares. The current market value of a fractional share of Common Stock shall be

  
 19 

 
determined (calculated to the nearest 1/10,000th of a share) by the Last Reported Sale Price of Common Stock on the Conversion Date (or, if the Conversion Date is not a Trading Day, the next
following Trading Day). 
 Section 5.04. [reserved]. 

Section 5.05. Adjustment of Conversion Rate. The Conversion Rate shall be adjusted as described below, except that
the Company will not make any adjustment to the Conversion Rate if Holders participate (other than in the case of a share split or share combination), solely as a result of holding the Notes, and at the same time and upon the same terms as holders
of Common Stock participate, in any of the transactions described below without having to convert their Notes, as if such Holders had held a number of shares of Common Stock equal to the applicable Conversion Rate in effect immediately prior to the
adjustment thereof in respect of such transaction, multiplied by the principal amount (expressed in thousands) of Notes held by such Holders. 
 (a) If the Company exclusively issues shares of Common Stock as a dividend or distribution on the Common Stock, or the Company effects a share split or share combination, the Conversion Rate will be
adjusted based on the following formula: 
  

							
	CR1
 = CR0
×	 	 OS1 	 
	 	 	 OS0 	  

      where, 
  

							
		  	CR0	    	=	    	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such dividend or distribution, or immediately prior to the Open of Business on the
effective date of such share split or combination, as the case may be;
				
		  	CR1	    	=	    	the Conversion Rate in effect immediately after the Close of Business on such Record Date or immediately after the Open of Business on such effective date, as the case may
be;
				
		  	OS0	    	=	    	the number of shares of Common Stock outstanding immediately prior to the Close of Business on such Record Date or immediately prior to the Open of Business on such effective date,
as the case may be; and
				
		  	OS1	    	=	    	the number of the shares of Common Stock that will be outstanding immediately after giving effect to such dividend or distribution or immediately after the effective date of such
share split or combination, as the case may be.

  
 20 

 Any adjustment made to the Conversion Rate under this Section 5.05(a) shall become effective
immediately after the Close of Business on the Record Date for such dividend or distribution or immediately after the Open of Business on the effective date of such share split or combination, as the case may be. If any dividend or distribution of
the type described in this Section 5.05(a) is declared but is not so paid or made, the Conversion Rate shall be immediately readjusted, effective as of the date the Board of Directors determines not to pay such dividend or distribution, to the
Conversion Rate that would then be in effect if such dividend or distribution had not been declared. For the avoidance of doubt, if the application of the foregoing formula would result in a decrease in the Conversion Rate, no adjustment to the
Conversion Rate will be made (other than (i) as a result of a share combination or (ii) with respect to the Company’s right to readjust the Conversion Rate). 
 (b) If the Company distributes to all or substantially all holders of the Common Stock any rights, options or warrants entitling them for a period of not more than 45 days after the Record Date for such
distribution to subscribe for or purchase shares of Common Stock, at a price per share less than the average of the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on, and including, the Trading Day
immediately preceding the date of announcement of such distribution, the Conversion Rate will be increased based on the following formula: 
  

					
	CR1 = CR0
×	 	 OS0 + X 
	 	 OS0 + Y 

       where 

 

							
		  	CR0	    	=	    	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such distribution;
				
		  	CR1	    	=	    	the Conversion Rate in effect immediately after the Close of Business on such Record Date;
				
		  	OS0	    	=	    	the number of shares of Common Stock outstanding immediately prior to the Close of Business on such Record Date;
				
		  	X	    	=	    	the total number of shares of Common Stock issuable pursuant to such rights, options or warrants; and
				
		  	Y	    	=	    	the number of shares of Common Stock equal to the aggregate price payable to exercise such rights, options or warrants divided by the average of the Last Reported Sale Prices of the
Common Stock over the ten consecutive Trading Day period ending on, and including, the Trading

  
 21 

							
		  		    		    	Day immediately preceding the date of announcement of such distribution.

 Any increase in the Conversion Rate made pursuant to this Section 5.05(b) shall be made successively whenever any
such rights, options or warrants are distributed and shall become effective immediately after the Close of Business on the Record Date for such issuance. To the extent that shares of Common Stock are not delivered after the expiration of such
rights, options or warrants, the Conversion Rate shall be immediately decreased to the Conversion Rate that would then be in effect had the increase with respect to the issuance of such rights, options or warrants been made on the basis of delivery
of only the number of shares of Common Stock actually delivered. If such rights, options or warrants are not so issued, the Conversion Rate shall be immediately decreased to the Conversion Rate that would then be in effect if such Record Date for
such issuance had not occurred. For the avoidance of doubt, if the application of the foregoing formula would result in a decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than with respect to the
Company’s right to readjust the Conversion Rate). 
 For purposes of this clause (b), in determining whether any rights,
options or warrants entitle the holders of shares of Common Stock to subscribe for or purchase shares of Common Stock at less than such average of the Last Reported Sale Prices of Common Stock for the ten consecutive Trading Day period ending on,
and including, the Trading Day immediately preceding the date of announcement of such distribution, and in determining the aggregate offering price of such shares of Common Stock, there shall be taken into account any consideration received by the
Company for such rights, options or warrants and any amount payable upon exercise or conversion thereof, the value of such consideration, if other than cash, to be determined by the Board of Directors. 

(c) If the Company distributes shares of Capital Stock, evidences of its indebtedness or other assets or property of the Company to all
or substantially all holders of Common Stock, excluding: 
 (i) dividends, distributions or issuances as to
which an adjustment was effected pursuant to Section 5.05(a) or (b) above; 
 (ii) dividends or
distributions paid exclusively in cash and as to which an adjustment was effected pursuant to Section 5.05(d) below; and 
 (iii) Spin-Offs as to which the provisions set forth below in this Section 5.05(c) shall apply; 
 then the Conversion Rate will be increased based on the following formula: 
  

					
	CR1 =
CR0 ×	 	SP0	 
	 	 	SP0 – FMV	  

  
 22 

      where, 

 

							
		  	CR0	  	=	    	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such distribution;
				
		  	CR1	  	=	    	the Conversion Rate in effect immediately after the Close of Business on such Record Date;
				
		  	SP0	  	=	    	the average of the Last Reported Sale Prices of Common Stock for the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the
Ex-Dividend Date for such distribution; and
				
		  	FMV	  	=	    	the Fair Market Value as determined by the Board of Directors of the shares of Capital Stock, evidences of indebtedness, assets or property to be distributed with respect to each
outstanding share of Common Stock on the Ex-Dividend Date for such distribution.

 Any increase in the Conversion Rate made under the portion of this clause (3) above will become
effective immediately after the Close of Business on the Record Date for such distribution. If such distribution is not so paid or made, the Conversion Rate shall be immediately decreased to be the Conversion Rate that would then be in effect if
such dividend or distribution had not been declared. For the avoidance of doubt, if the application of the foregoing formula would result in a decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than with
respect to the Company’s right to readjust the Conversion Rate). Notwithstanding the foregoing, if “FMV” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the foregoing increase, each Holder shall receive upon conversion, in respect of each
$1,000 principal amount of Notes held by such Holder, the amount and kind of the Company’s Capital Stock, evidences of the Company’s indebtedness or other assets or property of the Company that such Holder would have received if such
Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect on the Record Date for the distribution. 

With respect to an adjustment made in the Conversion Rate pursuant to this Section 5.05(c) where there has been a payment of a
dividend or other distribution on the Common Stock in shares of Capital Stock of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit, where such Capital Stock or similar equity interest is listed or
quoted on a United States national securities exchange (or will be so listed or quoted when issued) (the foregoing being referred to as a “Spin-Off”), the Conversion Rate will be increased based on the following formula: 

  
 23 

			
	CR1 =
CR0 ×	 	 FMV0 
+ MP0 
	 	MP0

      where, 
  

							
		 	CR0	  	=	    	the Conversion Rate in effect immediately prior to the end of the Valuation Period (as defined below);
				
		 	CR1	  	=	    	the Conversion Rate in effect immediately after the end of the Valuation Period;
				
		 	FMV0	  	=	    	the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of Common Stock applicable to one share of Common Stock
(determined by reference to the definition of Last Reported Sale Price set forth above as if references therein to Common Stock were to such Capital Stock or similar equity interest) over the first ten consecutive Trading Day period immediately
following, and including, the Ex-Dividend Date of the Spin-Off (the “Valuation Period”); and
				
		 	MP0	  	=	    	the average of the Last Reported Sale Prices of the Common Stock over the Valuation Period.

 Any increase in the Conversion Rate made under the preceding paragraph shall be determined as of the
Close of Business on the last Trading Day of the Valuation Period but will be given effect immediately after the Close of Business on the Record Date for the Spin-Off; provided that in respect of any conversion during the Valuation Period,
references within this clause (c) to ten consecutive Trading Days shall be deemed replaced with such lesser number of Trading Days as have elapsed from, and including the Ex-Dividend Date of such Spin-Off to, and including, the Conversion Date
in determining the applicable Conversion Rate. If any dividend or distribution that constitutes a Spin-Off is declared but not so paid or made, the Conversion Rate shall be immediately decreased, effective as of the date the Board of Directors
determines not to pay such dividend or distribution, to the Conversion Rate that would then be in effect if such dividend or distribution had not been declared or announced. For the avoidance of doubt, if the application of the foregoing formula
would result in a decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than with respect to the Company’s right to readjust the Conversion Rate). 

(d) If the Company pays any cash dividends or distributions to all or substantially all holders of Common Stock, the Conversion Rate will
be increased based on the following formula: 

  
 24 

					
	CR1 = CR0
×	 	 SP0
	  	 
	 	SP0 – C	  	

      where, 
  

							
		  	CR0	    	=	    	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such dividend or distribution;
				
		  	CR1	    	=	    	the Conversion Rate in effect immediately after the Close of Business on such Record Date;
				
		  	SP0	    	=	    	the average of the Last Reported Sale Prices of Common Stock over the ten consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the
Ex-Dividend Date for such dividend or distribution; and
				
		  	C	    	=	    	the amount in cash per share the Company distributes to holders of Common Stock.

 Any increase in the Conversion Rate made under this clause (d) shall become effective immediately
after the Close of Business on the Record Date for such dividend or distribution. If such dividend or distribution is not so paid or made, the Conversion Rate shall be immediately decreased, effective as of the date the Board of Directors determines
not to make or pay such dividend or distribution, to be the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. For the avoidance of doubt, if the application of the foregoing formula would result in
a decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than with respect to the Company’s right to readjust the Conversion Rate). 
 Notwithstanding the foregoing, if “C” (as defined above) is equal to or greater than “SP0” (as defined above), in lieu of the foregoing increase, each Holder shall receive upon conversion, for each $1,000
principal amount of Notes held by such Holder, the amount of cash that such Holder would have received if such Holder owned a number of shares of Common Stock equal to the Conversion Rate in effect on the Record Date for such dividend or
distribution. 
 (e) If the Company or any Subsidiary of the Company makes a payment in respect of a tender offer or exchange
offer for Common Stock, to the extent that the cash and value of any other consideration included in the payment per share of Common Stock exceeds the Last Reported Sale Price of the Company’s Common Stock on the Trading Day next succeeding the
last date (the “Expiration Date”) on which tenders or exchanges may be made pursuant to such tender or exchange offer, the Conversion Rate will be increased based on the following formula: 

  
 25 

					
	CR1 = CR0
×	 	 AC + (SP1 × OS1)

	 	OS0 ×SP1

      where, 
  

							
		 	CR0	    	=	    	the Conversion Rate in effect immediately prior to the Close of Business on the tenth Trading Day immediately following, and including, the Trading Day next succeeding the
Expiration Date;
				
		 	CR1	    	=	    	the Conversion Rate in effect immediately after the Close of Business on the tenth Trading Day immediately following, and including, the Trading Day next succeeding the Expiration
Date;
				
		 	 AC
	    	=	    	the aggregate value of all cash and any other consideration (as determined by the Board of Directors) paid or payable for shares purchased in such tender or exchange
offer;
				
		 	 OS0
	    	=	    	the number of shares of Common Stock outstanding immediately prior to the date such tender or exchange offer expires (before giving effect to such tender offer or exchange
offer);
				
		 	
OS1
	    	=	    	the number of shares of Common Stock outstanding immediately after the date such tender or exchange offer expires (after giving effect to such tender or exchange offer);
and
				
		 	
SP1
	    	=	    	the average of the Last Reported Sale Prices of Common Stock over the ten consecutive Trading Day period commencing on, and including, the Trading Day next succeeding the date such
tender or exchange offer expires.

 Any increase in the Conversion Rate made pursuant to this clause (e) shall be determined as of the
Close of Business on the tenth consecutive Trading Day next succeeding the Expiration Date but will be given effect as of the Close of Business on the Expiration Date. 
 For purposes of determining the Conversion Rate, in respect of any conversion during the ten consecutive Trading Day period commencing on, and including, the Trading Day next succeeding the Expiration
Date, references within this clause (e) to ten consecutive Trading Days shall be deemed replaced with such lesser number of Trading Days as have elapsed from, and including, the Trading Day next succeeding the Expiration Date to, and including,
the relevant Conversion Date. 

  
 26 

 For the avoidance of doubt, if the application of the foregoing formula would result in a
decrease in the Conversion Rate, no adjustment to the Conversion Rate will be made (other than with respect to the Company’s right to readjust the Conversion Rate). 
 (f) Notwithstanding the foregoing, if any increase to the Conversion Rate described in Section 5.05(a), (b), (c), (d) or (e) above becomes effective and, but for this Section 5.05(f),
a Holder that has converted its Notes: 
 (i) would receive shares of Common Stock based on an increased
Conversion Rate, and 
 (ii) would be a record holder of such shares of Common Stock on the Record Date,
effective date or Expiration Date for the dividend, distribution or other event giving rise to the increase or otherwise participates in such dividend, distribution or other event giving rise to the adjustment as a result of being treated as a
holder of record of such shares of Common Stock, 
 then, in lieu of receiving shares of Common Stock at such increased Conversion Rate, the
Company will adjust the number of shares of Common Stock and amount of cash, if any, that it delivers to such Holder as it determines is appropriate to reflect such Holder’s participation in the related dividend, distribution or other event
giving rise to such increase. 
 (g) To the extent that the Company has a stockholder rights plan in effect upon conversion of
the Notes into Common Stock, Holders will receive, in addition to any Common Stock, the rights under the stockholder rights plan, unless prior to any conversion, the rights have separated from the Common Stock, in which case the Conversion Rate will
be adjusted at the time of separation as if the Company distributed to all holders its Common stock, shares of its Capital Stock, evidences of indebtedness or assets as described in clause Section 5.05(c) above, subject to readjustment in the
event of the expiration, termination or redemption of such rights. 
 (h) Except as described herein, the Company will not
adjust the Conversion Rate for the issuance of shares of Common Stock or any securities convertible into or exchangeable for shares of Common Stock or the right to purchase shares of Common Stock or such convertible or exchangeable securities.
Without limiting the foregoing, the Conversion Rate will not be adjusted: 
 (i) upon the issuance of any shares
of Common Stock pursuant to any present or future plan providing for the reinvestment of dividends or interest payable on securities of the Company and the investment of additional optional amounts in shares of Common Stock under any plan;

  
 27 

 (ii) upon the issuance of any shares of Common Stock or options or rights to
purchase those shares pursuant to any present or future employee, director or consultant benefit plan or program of or assumed by the Company or any of its Subsidiaries; 

(iii) upon the issuance of any shares of Common Stock pursuant to any option, warrant, right or exercisable, exchangeable
or convertible security not described in the preceding clause (ii) and outstanding as of the date the Notes were first issued; 
 (iv) upon the issuance of any shares of Common Stock for cash or as consideration in a merger, purchase or similar transaction; 

(v) for a change in the par value of Common Stock; 

(vi) upon any repurchase of shares of Common Stock in the open market or in privately negotiated transactions by the
Company (including by way of accelerated share repurchase or other derivatives), in each case other than in transactions described under clause Section 5.05(e) above; or 

(vii) for accrued and unpaid interest. 
 (i) In addition to those adjustments required by Sections 5.05(a) through (e) above, and to the extent permitted by law and subject to the listing standards of The NASDAQ Global Selected Market,
the Company may from time to time increase the Conversion Rate by any amount for a period of at least 20 days, if the Board of Directors determines (which determination shall be conclusive) that such increase would be in the Company’s best
interest. Whenever the Conversion Rate is increased pursuant to the preceding sentence, the Company shall mail to Holders a notice of the increased Conversion Rate and the period during which it will be in effect at least 15 days prior to the date
the increased Conversion Rate takes effect, in accordance with applicable law. In addition, subject to the listing standards of The NASDAQ Global Select Market, the Company may also, but is not required to, increase the Conversion Rate to avoid or
diminish income tax to holders of Common Stock or rights to purchase shares of Common Stock in connection with any dividend or distribution of shares of Common Stock or rights to acquire shares of Common Stock or similar event. 

(j) [reserved]. 

(k) Adjustments to the applicable Conversion Rate shall be calculated to the nearest one ten-thousandth (1/10,000th) of a share. The
Company will not be required to make an adjustment in the Conversion Rate unless the adjustment would require a change of at least 1% in the applicable Conversion Rate. However, the Company will carry forward any adjustments that are less than 1% of
the Conversion Rate and make such carried-forward adjustments, regardless of 

  
 28 

 
whether the aggregate adjustment is less than 1%, (i) annually, on the anniversary of the first date of issue of the Notes and (ii) solely with respect to the Note to be converted, upon
conversion of any Note. 
 Section 5.06. Recapitalizations, Reclassifications and Changes of Shares of
Common Stock. In the event of: 
 (a) any recapitalization, reclassification or change of the Common Stock (other than
changes resulting from a share split or combination); 
 (b) a consolidation, merger or combination involving the Company; or

 (c) a sale or conveyance to another person of all or substantially all of the Company’s assets, 

in each case as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, other property or
assets (including cash or any combination thereof) (any such event, a “Merger Event”), then, at the effective time of the Merger Event, the Company shall execute with the Trustee a supplemental indenture permitted under Article 10
providing that the right to convert each $1,000 principal amount of Notes will be changed into a right to convert such Note into the kind and amount of shares of stock, other securities or other property or assets (including cash or any combination
thereof) that a holder of a number of shares of Common Stock equal to the applicable Conversion Rate immediately prior to such Merger Event would have owned or been entitled to receive upon such Merger Event (the “Reference
Property”). If such Merger Event causes the Common Stock to be converted into the right to receive more than a single type of consideration (determined based in part upon any form of stockholder election), the Reference Property into which
the Notes will be convertible will be deemed to be (i) the weighted average of the types and amounts of Reference Property received by the holders of the Common Stock that affirmatively make such an election or (ii) if no holders of Common
Stock affirmatively make such an election, the types and amount of consideration actually received by such holders. If such Merger Event also constitutes a Fundamental Change, a Holder may require the Company to repurchase all or a portion of its
Notes to the extent provided in Section 4.01. The Company shall notify Holders and the Trustee of the weighted average as soon as practicable after such determination is made. 

The above provisions of this Section shall similarly apply to successive Merger Events. 

Section 5.07. Adjustments of Prices. Whenever any provision of this Indenture requires the Company to calculate Last
Reported Sale Prices over a span of multiple days (including with respect to the “Stock Price” for purposes of a Make-Whole Fundamental Change), the Company will make appropriate adjustments to account for any adjustment to the Conversion
Rate that becomes 

  
 29 

 
effective, or any event requiring an adjustment to the Conversion Rate where the Ex-Dividend Date, Record Date, effective date or Expiration Date of the event occurs, at any time during the
period during which such prices are to be calculated. Such adjustments will be effective as of the Ex-Dividend Date, Record Date, effective date or Expiration Date, as the case may be, of the event causing the adjustment to the Conversion Rate.

 Section 5.08. Adjustment to Shares Delivered Upon Conversion Upon Make-Whole Fundamental Changes

 (a) If the Effective Date of a Make-Whole Fundamental Change occurs prior to the Stated Maturity and a Holder elects to
convert its Notes in connection with such Make-Whole Fundamental Change, the Company shall increase the Conversion Rate for the Notes so surrendered for conversion by a number of additional shares of Common Stock (the “Additional
Shares”) as described below. A conversion of Notes shall be deemed for these purposes to be “in connection with” such Make-Whole Fundamental Change if the Conversion Notice with respect to such Notes is received by the Conversion
Agent during the period from, and including, the Effective Date up to, and including, the Close of Business on the second scheduled Trading Day immediately prior to the related Fundamental Change Repurchase Date (or, in the case of a Make-Whole
Fundamental Change that would have been a Fundamental Change but for the proviso in clause (2) of the definition thereof, the 30th Scheduled Trading Day immediately following the Effective Date). 

(b) The number of Additional Shares by which the Conversion Rate will be increased in the event of a Make-Whole Fundamental Change shall
be determined by reference to the table attached as Schedule A hereto, based on the Effective Date and the price (the “Stock Price”) paid per share of Common Stock in the Make-Whole Fundamental Change. If the holders of
Common Stock receive only cash in the Make-Whole Fundamental Change, the Stock Price shall be the cash amount paid per share. Otherwise, the Stock Price shall be the average of the Last Reported Sale Prices of the Common Stock over the ten
consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the relevant Effective Date. 

(c) The Stock Prices set forth in the first row (i.e., the column headers) of the table in Schedule A hereto shall be adjusted as
of any date on which the Conversion Rate is otherwise adjusted. The adjusted Stock Prices shall equal the Stock Prices applicable immediately prior to such adjustment, multiplied by a fraction, the numerator of which is the Conversion Rate
immediately prior to such adjustment giving rise to the Stock Price adjustment and the denominator of which is the Conversion Rate as so adjusted. The number of Additional Shares set forth in such table shall be adjusted in the same manner as the
Conversion Rate as set forth in Section 5.05. 

  
 30 

 (d) The exact Stock Prices and Effective Dates may not be set forth in the table in
Schedule A, in which case: 
 (i) If the Stock Price is between two Stock Price amounts in the table or
the Effective Date is between two Effective Dates in the table, the number of Additional Shares will be determined by a straight-line interpolation between the number of Additional Shares set forth for the higher and lower Stock Price amounts and
the two dates, as applicable, based on a 365-day year. 
 (ii) If the Stock Price is greater than $70.00 per
share (subject to adjustment in the same manner as the Stock Prices as set forth in the column headings of the table in Schedule A), no Additional Shares will be added to the Conversion Rate. 

(iii) If the Stock Price is less than $24.00 per share (subject to adjustment in the same manner as the Stock Prices as
set forth in the column headings of the table in Schedule A), no Additional Shares will be added to the Conversion Rate. 

Notwithstanding the foregoing, in no event shall the Conversion Rate exceed 41.6667 per $1,000 principal amount of Notes, subject to
adjustments in the same manner as the Conversion Rate as set forth in Section 5.05. 
 (e) If a Holder of Notes elects to
convert its Notes prior to the Effective Date of any Fundamental Change, such Holder shall not be entitled to an increased Conversion Rate in connection with such conversion. 
 (f) Any conversion that entitles the converting Holder to an increase in the Conversion Rate as described in this Section 5.08 shall be settled as described under Section 5.03. 

Section 5.09. Taxes on Shares Issued. Any issue of Common Stock share certificates on conversions of Notes shall be made
without charge to the converting Holder for any documentary, transfer, stamp or any similar tax in respect of the issue thereof, and the Company shall pay any and all documentary, stamp or similar issue or transfer taxes that may be payable in
respect of the issue or delivery of shares of Common Stock on conversion of Notes pursuant hereto. The Company shall not, however, be required to pay any such tax which may be payable in respect of any transfer involved in the issue and delivery of
shares of Common Stock in any name other than that of the Holder of any Notes converted, and the Company shall not be required to issue or deliver any such Common Stock share certificate unless and until the Person or Persons requesting the issue
thereof shall have paid to the Company the amount of such tax or shall have established to the satisfaction of the Company that such tax has been paid. 

  
 31 

 Section 5.10. Reservation of Shares; Shares to be Fully Paid; Compliance
with Governmental Requirements. The Company shall provide, free from preemptive rights, out of its authorized but unissued shares of Common Stock or shares of Common Stock held in treasury, sufficient Common Stock to provide for the conversion
of the Notes from time to time as such Notes are presented for conversion. 
 The Company covenants that all shares of Common
Stock that may be issued upon conversion of Notes shall be newly issued shares or treasury shares, shall be duly authorized, validly issued, fully paid and non-assessable and shall be free from preemptive rights and free from any lien or adverse
claim. 
 Section 5.11. Responsibility of Trustee. The Trustee has no duty to determine when an adjustment under
this Article 5 should be made, how it should be made or what it should be. The Trustee and any other Conversion Agent shall not at any time be under any duty or responsibility to any Holder to determine the Conversion Rate or whether any facts exist
which may require any adjustment of the Conversion Rate, or with respect to the nature or extent or calculation of any such adjustment when made, or with respect to the method employed, or herein or in any supplemental indenture provided to be
employed, in making the same. The Trustee and any other Conversion Agent shall not be accountable with respect to the validity or value (or the kind or amount) of any Common Stock, or of any securities or property, which may at any time be issued or
delivered upon the conversion of any Notes; and the Trustee and any other Conversion Agent make no representations with respect thereto. Neither the Trustee nor any Conversion Agent shall be responsible for any failure of the Company to comply with
any of the duties, responsibilities or covenants of the Company contained in this Article 5. Without limiting the generality of the foregoing, neither the Trustee nor any Conversion Agent shall be under any responsibility to determine whether a
supplemental indenture needs to be entered into or the correctness of any provisions contained in any supplemental indenture entered into and may accept as conclusive evidence of the correctness of any such provisions, and shall be protected in
relying upon, the Officers’ Certificate (which the Company shall be obligated to file with the Trustee prior to the execution of any such supplemental indenture) with respect thereto. For the avoidance of doubt, neither the Trustee nor the
Conversion Agent shall be responsible for making any calculations under this Article 5 nor for monitoring the price of the Common Stock. 
 Section 5.12. [reserved]. 
 Section 5.13. Stockholder Rights
Plan. Each share of Common Stock issued upon conversion of Notes pursuant to this Article 5 shall be entitled to receive the appropriate number of rights, if any, and the certificates representing the shares of Common Stock issued upon such
conversion shall bear such legends, if any, in each case as may be provided by the terms of any subsequent stockholder rights agreement adopted by the Company, as any such 

  
 32 

 
agreement may be amended from time to time. Notwithstanding the foregoing, if prior to any conversion such rights have separated from the shares of Common Stock in accordance with the provisions
of the applicable stockholder rights agreement, the Conversion Rate shall be adjusted at the time of separation as if the Company had distributed to all Holders of the Common Stock, shares of the Company’s Capital Stock, evidences of
indebtedness, assets, property, rights or warrants as described in Section 5.05(c) above, subject to readjustment in the event of the expiration, termination or redemption of such rights. Any distribution of rights or warrants pursuant to a
rights plan that would allow a Holder to receive upon conversion, in addition to shares of Common Stock, the rights described therein with respect to such Common Stock (unless such rights or warrants have separated from the Common Stock) shall not
constitute a distribution of rights or warrants that would entitle the Holder to an adjustment to the Conversion Rate. 

Section 5.14. Company Determination Final. Any determination that the Company or its Board of Directors must make pursuant
to this Article 5 shall be conclusive if made in good faith, absent manifest error. 
 ARTICLE 6 

REDEMPTION 
 Section 6.01. Optional Redemption. 
 (a) Pursuant to Section 3.1
of the Base Indenture, the Notes are redeemable on the terms and subject to the conditions set forth in this Article 6. 
 (b)
Sections 3.2, 3.3, 3.4, 3.5 and 3.6 of the Base Indenture shall not apply to the Notes. No sinking fund is provided for the Notes and therefore, Article XI of the Base Indenture shall not apply to the Notes. 

Section 6.02. Right to Redeem; Notices to Trustee.  

(a) On or after September 20, 2015, the Company may redeem any or all of the Notes, except Notes that it is required to repurchase
pursuant to Section 4.01, in cash at the Redemption Price (as defined below); provided that the Last Reported Sale Price of the Common Stock for 20 or more Trading Days in a period of 30 consecutive Trading Days ending within ten Trading Days
immediately prior to the date of the Notice of Redemption exceeds 130% of the applicable Conversion Price in effect on each such Trading Day. 
 (b) The redemption price (the “Redemption Price”) shall be equal to 100% of the principal amount of the Notes being redeemed, plus accrued and unpaid interest (including Additional
Interest), if any, to, but excluding, the Redemption Date. Any Notes so redeemed will be paid for in cash. 

  
 33 

 Section 6.03. Selection of Notes to be Redeemed. If less than all
the outstanding Notes are to be redeemed, the Trustee shall select the Notes to be redeemed on a pro rata basis or by any other method the Trustee considers reasonable, fair and appropriate. The Trustee shall make the selection within seven days
from its receipt of the Notice of Redemption from outstanding Notes not previously called for redemption. 
 Notes and portions
of Notes the Trustee selects shall be in principal amounts of $1,000 or integral multiples of $1,000, by lot. Provisions of this Indenture that apply to Notes called for redemption in whole also apply to Notes called for redemption in part. The
Trustee shall notify the Company promptly of the Notes or portions of Notes to be redeemed. 
 If any Notes selected for partial
redemption are converted in part before termination of the conversion right with respect to the portion of the Note so selected, the converted portion of such Note shall be deemed to be of the portion selected for redemption. Notes which have been
converted during a selection of Notes to be redeemed may be treated by the Trustee as outstanding for the purpose of such selection. 
 Section 6.04. Notice of Redemption. The Company shall mail a notice of redemption (“Notice of Redemption”) not more than 60 calendar days but not less than 30 calendar days
prior to the Redemption Date, to the Trustee, the Paying Agent and each Holder of Notes to be redeemed to the addresses set forth in the register of the Registrar. 
 The notice shall specify the Notes to be redeemed and shall state: 
 (a) the
Redemption Date; 
 (b) the Redemption Price; 
 (c) the Applicable Conversion Rate and approximate Conversion Price; 
 (d) the
name and address of the Paying Agent and Conversion Agent; 
 (e) that the right to convert the Notes called for redemption will
expire on the Close of Business on the second Scheduled Trading Day immediately preceding the Redemption Date unless the Company fails to pay the Redemption Price (in which case a Holder may convert its Notes so called until the Redemption Price has
been paid or duly provided for); 
 (f) that Holders who want to convert Notes must satisfy the requirements set forth therein
and in this Indenture; 
 (g) that Notes called for redemption must be surrendered to the Paying Agent to collect the Redemption
Price; 

  
 34 

 (h) if fewer than all the outstanding Notes are to be redeemed, the certificate numbers (if
such Notes are not Global Notes) and principal amounts of the particular Notes to be redeemed; 
 (i) that, unless the Company
defaults in making payment of such Redemption Price, interest will cease to accrue on and after the Redemption Date; and 
 (j)
the CUSIP number of the Notes. 
 At the Company’s written request, the Trustee shall give the Notice of Redemption to each
Holder of Notes to be redeemed in the Company’s name and at the Company’s expense, provided, however, that the Company has delivered to the Trustee, at least 5 days (unless a shorter time should be acceptable to the Trustee)
prior to the notice date, an Officer’s Certificate requesting that the Trustee give such notice and setting forth the information to be stated in such notice. 
 Section 6.05. Effect of Notice of Redemption. Once a Notice of Redemption is given, Notes called for redemption become due and payable on the Redemption Date and at the Redemption Price stated
in the Notice of Redemption except for Notes that are converted in accordance with the terms of this Indenture. Upon surrender to the Paying Agent, such Notes shall be paid at the Redemption Price stated in the Notice of Redemption. 

Section 6.06. Deposit of Redemption Price. On or prior to 11:00 a.m. (New York City time) on the Redemption Date, the
Company shall deposit with the Trustee or with the Paying Agent (or, if the Company or a Subsidiary of the Company or an Affiliate of either of them is acting as the Paying Agent, shall segregate and hold in trust as provided in Section 2.04)
an amount of money (in immediately available funds if deposited on such Redemption Date) sufficient to pay the aggregate Redemption Price of all the Notes or portions thereof which are to be redeemed as of the Redemption Date. 

If the Paying Agent holds money sufficient to pay the Redemption Price with respect to the Notes to be redeemed on the Redemption Date in
accordance with the terms of this Indenture, then, immediately on and after the Redemption Date, interest on such Notes shall cease to accrue, whether or not the Notes are delivered to the Paying Agent, and all other rights of the Holders of such
Notes shall terminate, other than the right to receive the Redemption Price upon delivery of such Notes. 
 Section 6.07.
Notes Redeemed in Part. Any certificated Notes which is to be redeemed only in part shall be surrendered at the office of the Paying Agent (with, if the Company or the Trustee so requires, due endorsement by, or a written instrument of
transfer in form satisfactory to the Company and the Trustee duly executed by, the Holder thereof or such Holder’s attorney duly 

  
 35 

 
authorized in writing) and the Company shall execute and the Trustee shall authenticate and deliver to the Holder of such certificated Note, without service charge, a new certificated Note or new
certificated Notes, of any authorized denomination as requested by such Holder in aggregate principal amount equal to, and in exchange for, the portion of the principal amount of the certificated Notes so surrendered that is not redeemed, subject to
Section 6.09. 
 Section 6.08. Payment of Interest Upon Redemption. If Notes are redeemed on a date that is
after a Regular Record Date for an Interest Payment Date and prior to the corresponding Interest Payment Date, the Company will not pay accrued interest to the Holder of Notes being redeemed, and will instead pay the full amount of the relevant
interest payment on such Interest Payment Date to the Holder of record on such Regular Record Date. 
 Section 6.09.
Transfer and Exchange Upon Redemption. In the event of any redemption in part, the Company shall not be required to (i) issue, register the transfer of or exchange any Notes during a period beginning at the Open of Business 15 days
before any selection for redemption of Notes and ending at the Close of Business on the earliest date on which the relevant Notice of Redemption is deemed to have been given to all Holders of Notes to be redeemed or (ii) register the transfer
of or exchange any Notes so selected for redemption, in whole or in part, except the unredeemed portion of any Notes being redeemed in part. 
 Section 6.10. Effect of Acceleration. No Notes may be redeemed if the principal amount of the Notes has been accelerated pursuant to Article 7, and such acceleration has not been rescinded, on
or prior to the Redemption Date (except in the case of an acceleration resulting from a Default by the Company in the payment of the applicable Redemption Price with respect to such Notes). 

ARTICLE 7 

REMEDIES 
 Section 7.01. Events of Default.  
 (a) The provisions of this Article
7 shall, with respect to the Notes, supersede in its entirety Article VI of the Base Indenture. 
 (b) “Event of
Default”, wherever used herein, means any one of the following events: 
 (i) default in the payment of
any interest (including Additional Interest) on any Note when it becomes due and payable and such default continues for a period of 30 days; or 

  
 36 

 (ii) default in the payment of the principal of any Note when due and
payable at its Stated Maturity, upon required repurchase, upon declaration of acceleration or otherwise; or 

(iii) default in the Company’s obligation to deliver shares of Common Stock required to be delivered upon conversion
of the Notes, together with cash in lieu thereof in respect of any fractional shares of Common Stock upon conversion of any Notes, and such default continues for three Business Days; or; 

(iv) failure by the Company to comply with its obligations under Article 8; or 

(v) failure by the Company to issue a Fundamental Change Repurchase Right Notice in accordance with Section 4.01; or

 (vi) failure by the Company for 60 days after written notice from the Trustee or the Holders of at least 25%
principal amount of the Notes then outstanding has been received by the Company to comply with any of its other agreements contained in the Notes or this Indenture; or 

(vii) default by the Company or any of its Subsidiaries with respect to any mortgage, agreement or other instrument under
which there may be outstanding, or there may be secured or evidenced, any debt for money borrowed in excess of $35,000,000 in the aggregate of the Company and/or such Subsidiary, whether such debt now exists or shall hereafter be created, which
default results (i) in such debt becoming or being declared due and payable, and such debt has not been discharged in full or such declaration rescinded or annulled within 60 days or (ii) from a failure to pay the principal of any such
debt when due and payable at its Stated Maturity, upon required repurchase, upon declaration of acceleration or otherwise, and such defaulted payment shall not have been made, waived or extended within 60 days; or 

(viii) a final judgment for the payment of $35,000,000 or more (excluding any amounts covered by insurance) rendered
against the Company or any of its Subsidiaries, which judgment is not discharged, stayed, vacated, paid or otherwise satisfied within 60 days after (i) the date on which the right to appeal thereof has expired if no such appeal has commenced,
or (ii) the date on which all rights to appeal have been extinguished; or 
 (ix) the Company or any of its
Significant Subsidiaries shall commence a voluntary case or other proceeding seeking liquidation, reorganization or other relief with respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or
seeking the appointment of a trustee, receiver, liquidator, custodian or 

  
 37 

 
other similar official of the Company or any of its Significant Subsidiaries or any substantial part of its respective property, or shall consent to any such relief or to the appointment of or
taking possession by any such official in an involuntary case or other proceeding commenced against it, or shall make a general assignment for the benefit of creditors, or shall fail generally to pay its debts as they become due; or 

(x) an involuntary case or other proceeding shall be commenced against the Company or any of its Significant Subsidiaries
seeking liquidation, reorganization or other relief with respect to it or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other
similar official of the Company or any of its Significant Subsidiaries or any substantial part of its respective property, and such involuntary case or other proceeding shall remain undismissed and unstayed for a period of 60 consecutive days.

 Section 7.02. Acceleration of Maturity; Rescission and Annulment.  

(a) If an Event of Default occurs and is continuing, the Trustee by notice to the Company, or the Holders of at least 25% in principal
amount of the outstanding Notes by notice to the Company and the Trustee, may, and the Trustee at the request of such Holders shall, declare 100% of the principal and accrued and unpaid interest on all Notes to be due and payable immediately. Upon
such a declaration, such principal and accrued and unpaid interest shall become due and payable immediately. However, upon an Event of Default arising out of Section 7.01(b)(viii)(except, in either case, with respect to any Significant
Subsidiary) the aggregate principal amount and accrued and unpaid interest shall be due and payable immediately without notice from the Trustee or Holders. 
 Notwithstanding the foregoing, at the election of the Company, the sole remedy with respect to an Event of Default for the failure by the Company to comply with its obligations as set forth in
Section 3.06 (any such Event of Default, a “Reporting Event of Default”) shall, for the first 360 days after the occurrence of such Reporting Event of Default consist exclusively of the right to receive additional interest (the
“Additional Interest”) on the Notes at an annual rate equal to (i) 0.25% per annum of the principal amount of the Notes outstanding for each day during the 180-day period on which such Reporting Event of Default is
continuing beginning on, and including, the date on which such Reporting Event of Default first occurs and (ii) 0.50% per annum of the principal amount of the Notes outstanding for each day during the 180-day period on which such Reporting
Event of Default is continuing beginning on, and including, the 181st day on which such Reporting Event of Default is continuing. If the Company so elects, the Additional Interest shall be payable as provided in Section 3.08. On the 361st day after such Reporting Event of Default (if the Reporting Event of
Default is not cured or waived prior to such 361st day),
the Trustee or the Holders 

  
 38 

 
of not less than 25% in principal amount of the outstanding Notes may declare the principal of and accrued and unpaid interest on all such Notes to be due and payable immediately. The provisions
described in this paragraph shall not affect the rights of Holders in the event of the occurrence of any other Event of Default. In the event the Company does not elect to pay Additional Interest following a Reporting Event of Default in accordance
with this paragraph or the Company elected to make such payment but does not pay such Additional Interest when due, the Notes shall be immediately subject to acceleration as provided above. In no event shall Additional Interest payable pursuant to
the foregoing election accrue at a rate per year in excess of the applicable rate specified in this paragraph, regardless of the number of events or circumstances giving rise to requirements to pay such Additional Interest pursuant to this
paragraph. With regard to any Reporting Event of Default, no Additional Interest shall accrue after such Reporting Event of Default has been cured. 
 (b) If the Company elects to pay the Additional Interest as the sole remedy during the first 360 days after the occurrence of a Reporting Event of Default, the Company shall notify in writing the Holders,
the Trustee and the Paying Agent of such election prior to the beginning of such 360-day period. Upon the Company’s failure to timely give such notice, the Notes will be immediately subject to acceleration as provided in the first paragraph of
Section 7.02(a) above. 
 Section 7.03. Collection of Indebtedness and Suits for Enforcement by
Trustee.  
 The Company covenants that if 
 (a) default is made in the payment of any interest on any Note when such interest becomes due and payable and such default continues for a period of 30 days, or 

(b) default is made in the payment of the principal of any Note when due and payable at the Stated Maturity thereof, 

the Company will, upon demand of the Trustee, pay to it, for the benefit of the Holders of such Notes, the whole amount then due and payable on such
Notes for principal and interest, and, to the extent that payment of such interest shall be legally enforceable, interest on any overdue principal and on any overdue interest, at the rate borne by the Notes, and, in addition thereto, such further
amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 

If an Event of Default occurs and is continuing, the Trustee may in its discretion proceed to protect and enforce its rights and the
rights of the Holders by such appropriate judicial proceedings as the Trustee shall deem most effectual to 

  
 39 

 
protect and enforce any such rights, whether for the specific enforcement of any covenant or agreement in this Indenture or in aid of the exercise of any power granted herein, or to enforce any
other proper remedy. 
 Section 7.04. Trustee May File Proofs of Claim.  

In case of any judicial proceeding relative to the Company (or any other obligor upon the Notes), its property or its creditors, the
Trustee shall be entitled and empowered, by intervention in such proceeding or otherwise, to take any and all actions authorized under the TIA in order to have claims of the Holders and the Trustee allowed in any such proceeding. In particular, the
Trustee shall be authorized to collect and receive any moneys or other property payable or deliverable on any such claims and to distribute the same; and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official
in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any amount due it
for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 7.7 of the Base Indenture. 

No provision of this Indenture shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any
Holder any plan of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any Holder thereof or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 

Section 7.05. Trustee May Enforce Claims Without Possession of Notes.  

All rights of action and claims under this Indenture or the Notes may be prosecuted and enforced by the Trustee without the possession of
any of the Notes or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for
the payment of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable benefit of the Holders of the Notes in respect of which such judgment has been recovered. 

Section 7.06. Application of Money Collected.  
 Subject to Article 5, any money or property money collected by the Trustee pursuant to this Article shall be applied in the following order, at the date or dates fixed by the Trustee and, in case of the
distribution of such money on account of principal or interest, upon presentation of the Notes and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid: 

  
 40 

 FIRST: To the payment of all amounts due the Trustee under Section 7.7 of the Base
Indenture; 
 SECOND: To the payment of the amounts then due and unpaid for principal of and interest on the Notes in respect of
which or for the benefit of which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on such Notes for principal and interest, respectively; and 

THIRD: The balance, if any, to the Company. 
 Section 7.07. Limitation on Suits.  
 Subject to Section 7.08, no
Holder shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, or for the appointment of a receiver or trustee, or for any other remedy hereunder, unless: 

(a) such Holder has previously given written notice to the Trustee of a continuing Event of Default; 

(b) the Holders of at least 25% in principal amount of the outstanding Notes shall have made written request to the Trustee to pursue the
remedy; 
 (c) such Holders have offered to the Trustee security or indemnity satisfactory to it against the loss, liability or
expense to be incurred in compliance with such request; 
 (d) the Trustee has not complied with such request for 60 days after
its receipt of such notice and offer of security or indemnity; and 
 (e) the Holders of a majority in principal amount of the
outstanding Notes have not given the Trustee a direction that, in the opinion of the Trustee, inconsistent with such written request within such 60-day period; 
 it being understood and intended that no one or more Holders shall have any right in any manner whatever by virtue of, or by availing of, any provision of this Indenture to affect, disturb or prejudice
the rights of any other Holders, or to obtain or to seek to obtain priority or preference over any other Holders or to enforce any right under this Indenture, except in the manner herein provided and for the equal and ratable benefit of all the
Holders. 
 Section 7.08. Unconditional Right of Holders to Receive Principal and Interest and to Convert. 

 Notwithstanding any other provision in this Indenture, the Holder of any Note shall have the right, which is absolute and
unconditional, to receive payment of the principal of and interest (including Additional Interest) on such Note when due and to convert such Note in accordance with Article 5 and to institute suit for

  
 41 

 
the enforcement of any such payment and right to convert, and such rights shall not be impaired without the consent of such Holder. 

Section 7.09. Restoration of Rights and Remedies.  
 If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been discontinued or abandoned for any reason, or has been determined
adversely to the Trustee or to such Holder, then and in every such case, subject to any determination in such proceeding, the Company, the Trustee and the Holders shall be restored severally and respectively to their former positions hereunder and
thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding had been instituted. 
 Section 7.10. Rights and Remedies Cumulative.  
 Except as otherwise
provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Notes in Section 2.8 of the Base Indenture, no right or remedy herein conferred upon or reserved to the Trustee or to the Holders is intended to be
exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise.
The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other appropriate right or remedy. 
 Section 7.11. Delay or Omission Not Waiver.  
 No delay or omission of
the Trustee or of any Holder of any Note to exercise any right or remedy accruing upon any Event of Default shall impair any such right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy
given by this Article or by law to the Trustee or to the Holders may be exercised from time to time, and as often as may be deemed expedient, by the Trustee (subject to the limitations contained in this Indenture) or by the Holders, as the case may
be. 
 Section 7.12. Control by Holders.  
 The Holders of a majority in principal amount of the outstanding Notes shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee or
exercising any trust or power conferred on the Trustee, provided that: 
 (a) such direction shall not be in conflict
with any rule of law or with this Indenture and shall not be unduly prejudicial to the rights of any other Holder or result in personal liability to the Trustee, and 

  
 42 

 (b) the Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction or this Indenture; 
 and provided, further that, if an Event of Default occurs and is
continuing, the Trustee shall be under no obligation to exercise any of its rights or powers under this Indenture at the request or direction of any of the Holders unless such Holders have offered to the Trustee indemnity or security satisfactory to
it against any loss, liability or expense. 
 Section 7.13. Waiver of Past Defaults and Rescission.  

The Holders of a majority in principal amount of the outstanding Notes may on behalf of the Holders of all the Notes: 

(a) waive any existing Default or Event of Default hereunder and its consequences, except a Default: 

(i) in the payment of the principal of or accrued and unpaid interest (including Additional Interest, if any) on any Note
that remains uncured, or 
 (ii) in respect of the failure to deliver amounts due upon conversion of a Note in
accordance with Section 5.01 hereunder, and 
 (b) at any time after a declaration of acceleration has been made and before
a judgment or decree for payment of the money due has been obtained by the Trustee as hereinafter in this Article 7 provided, rescind and annul any such declaration of acceleration with respect to the Notes and its consequences, if: 

(i) such rescission will not conflict with any judgment or decree of a court of competent jurisdiction, and 

(ii) all existing Events of Default, other than nonpayment of the principal of or accrued and unpaid interest (including
Additional Interest, if any) on any Note or a failure to deliver amounts due upon conversion of a Note in accordance with Section 5.01 hereunder, have been cured or waived. 

Upon any such waiver, such Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured,
for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other Default or impair any right consequent thereon. 
 Section 7.14. Undertaking for Costs.  
 In any suit for the
enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken, suffered or omitted by it as Trustee, a court may require any party litigant in such suit to file an undertaking

  
 43 

 
to pay the costs of such suit, and may assess costs against any such party litigant, in the manner and to the extent provided in the TIA; provided, that neither this Section nor the TIA
shall be deemed to authorize any court to require such an undertaking or to make such an assessment in any suit instituted by the Trustee, to any suit by any Holder or group of Holders holding in the aggregate more than 10% in principal amount of
the outstanding Notes or in any suit for the enforcement of the right to convert any Note in accordance with Article 12 or for the enforcement of the payment of the principal of or interest on any Note on or after the maturity of such Note,
including the Stated Maturity expressed in such Note. 
 Section 7.15. [reserved].  

Section 7.16. Notice of Default.  
 The provisions of this Section 7.16 shall, with respect to the Notes, supersede in its entirety the second paragraph of Section 4.3 of the Base Indenture. 

The Company shall deliver to the Trustee, within 30 days after the occurrence of any events that constitute a Default or Event of
Default, an Officer’s Certificate specifying such Default or Event of Default, the status such events and what action the Company is taking or proposes to take with respect thereof. 

Section 7.17. Interest on Overdue Payments.  
 Payments of any Fundamental Change Repurchase Price, Redemption Price, principal and interest (including Additional Interest) that are not made when due will accrue interest per annum at the
then-applicable interest rate from the required payment date. 
 ARTICLE 8 

CONSOLIDATION, MERGER, CONVEYANCE, TRANSFER OR
LEASE 
 Section 8.01. Company May Consolidate, Etc., Only on Certain Terms.  

This Section 8.01 shall, with respect to the Notes, supersede in its entirety Section 5.1 of the Base Indenture. 

The Company shall not consolidate with or merge with or into, or convey, transfer or lease all or substantially all of its properties and
assets to, another Person, unless: 
 (i) the resulting, surviving or transferee Person, if other than the
Company, is a Person organized and existing under the laws of the United States of America, any State thereof or the District of Columbia, 

  
 44 

 
and such Person, if not the Company, shall expressly assume, by supplemental indenture hereto, executed and delivered to the Trustee, all obligations of the Company under the Notes and this
Indenture; 
 (ii) immediately after giving effect to such transaction, no Default has occurred and is
continuing; and 
 (iii) the Company, or the successor Person if other than the Company, has delivered to the
Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that such consolidation, merger, conveyance, transfer or lease and, if a supplemental indenture is required in connection with such transaction, such supplemental
indenture comply with this Article and that all conditions precedent herein provided for relating to such transaction have been complied with. 
 Section 8.02. Successor Substituted.  
 This Section 8.02 shall,
with respect to the Notes, supersede in its entirety Section 5.2 of the Base Indenture. 
 Upon any transaction referred to
in Section 8.01 in accordance therewith, the successor Person formed by such consolidation or into which the Company is merged or to which such conveyance, transfer or lease is made shall succeed to, and be substituted for, and may exercise
every right and power of, the Company under this Indenture with the same effect as if such successor Person had been named as the Company herein; provided, however, that the predecessor Company in the case of a sale, conveyance or
other disposition (other than a lease) shall be released from all obligations and covenants under this Indenture and the Notes. 

ARTICLE 9 

SATISFACTION AND DISCHARGE 

Section 9.01. Satisfaction and Discharge of Indenture.  

(a) Subject to Section 1.02 hereof, the provisions of Article VIII of the Base Indenture, as supplemented by the provisions of this
Supplemental Indenture, shall apply to the Notes. 
 (b) Sections 8.1, 8.3 and 8.4 of the Base Indenture shall not apply to the
Notes. 
 (c) When (i) the Company shall deliver to the Trustee for cancellation all Notes theretofore authenticated (other
than any Notes that have been destroyed, lost or stolen and in lieu of or in substitution for which other Notes shall have been authenticated and delivered) and not theretofore canceled, or (ii) all the Notes not theretofore canceled or
delivered to the Trustee for cancellation shall have become due and payable, and the Company shall deposit with the Trustee, in 

  
 45 

 
trust, cash or shares of Common Stock, as applicable, sufficient to pay at the Stated Maturity, upon conversion, upon any Redemption Date or Fundamental Change Date or upon redemption of all of
the Notes (other than any Notes that shall have been mutilated, destroyed, lost or stolen and in lieu of or in substitution for which other Notes shall have been authenticated and delivered) not theretofore canceled or delivered to the Trustee for
cancellation, including principal and interest (including Additional Interest, if any) due or to become due to such Stated Maturity, Redemption Date of Fundamental Change Purchase Date, as the case may be, and if the Company shall also pay or cause
to be paid all other sums payable hereunder by the Company, then this Indenture shall cease to be of further effect (except as to (A) remaining rights of registration of transfer, substitution and exchange and conversion of Notes,
(B) rights hereunder of Holders to receive payments of principal of and interest (including Additional Interest, if any) on, the Notes and the other rights, duties and obligations of Holders, as beneficiaries hereof with respect to the amounts,
if any, so deposited with the Trustee and (C) the rights, obligations and immunities of the Trustee hereunder), and the Trustee, on written demand of the Company accompanied by an Officers’ Certificate and an Opinion of Counsel and at the
reasonable cost and expense of the Company, shall execute proper instruments acknowledging satisfaction of and discharging this Indenture; the Company, however, hereby agrees to reimburse the Trustee for any costs or expenses thereafter reasonably
and properly incurred by the Trustee and to compensate the Trustee for any services thereafter reasonably and properly rendered by the Trustee in connection with this Indenture or the Notes. Notwithstanding the satisfaction and discharge of this
Indenture, the obligations of the Company to the Trustee under Section 7.7 of the Base Indenture, and if money shall have been deposited with the Trustee pursuant to this Section 9.01(c), the provisions of Section 2.4, 2.7, 2.8, 8.2
and 8.5 of the Base Indenture shall survive. 
 ARTICLE 10 

SUPPLEMENTAL INDENTURES 
 Section 10.01. Supplemental Indentures. Subject to Section 1.02 hereof, the provisions of Article IX of the Base Indenture, as supplemented by the provisions of this Supplemental
Indenture, shall apply to the Notes. 
 Any Notes held by the Company or any of its Affiliates shall be disregarded (from both
the numerator and the denominator) for purposes of determining whether the Holders of the requisite aggregate principal amount of the outstanding Notes have consented to a modification, amendment or waiver of the terms of the Indenture. 

Section 10.02. Supplemental Indentures Without Consent of Holders. 

  
 46 

 This Section 10.02 shall, with respect to the Notes, supersede Section 9.1 of the
Base Indenture in its entirety. Without the consent of any Holder, the Company, when authorized by a Board Resolution, and the Trustee, at any time and from time to time, may enter into one or more indentures supplemental hereto, in form reasonably
satisfactory to the Trustee and the Company, for any of the following purposes: 
 (a) to cure any ambiguity, omission , defect
or omission or inconsistency; including to eliminate any conflict with the terms of the TIA; 
 (b) to provide for the
assumption of the Company’s obligations under this Indenture by a successor pursuant to Article 8; 
 (c) to provide any
security for or add guarantees with respect to the Notes; 
 (d) to add to the covenants of the Company for the benefit of the
Holders or surrender any right or power conferred upon the Company; 
 (e) to provide for conversion of the Notes in accordance
with the terms of this Indenture; 
 (f) to make any other change that does not adversely affect the rights of any Holder of
outstanding Notes (other than any Holder that consents to such change); 
 (g) to comply with any requirement of the SEC in
connection with any qualification of this Indenture under the TIA; 
 (h) to conform the provisions of this Indenture or the
Notes to the “Description of Notes” section of the Company’s preliminary prospectus supplement dated September 13, 2011 relating to the offering of the Notes as supplemented by the Company’s second free writing prospectus
dated September 13, 2011 relating thereto; 
 (i) to provide for a successor Trustee; or 

(j) to comply with the Applicable Procedures of the Depositary; 

Section 10.03. Supplemental Indentures with Consent of Holders.  

This Section 10.03 shall, with respect to the Notes, supersede Sections 9.2 and 9.3 of the Base Indenture in their entirety.
With the consent of the Holders of not less than a majority in principal amount of the outstanding Notes, including without limitation, consents obtained in connection with a purchase of, or tender offer or exchange offer for, the Company, when
authorized by a Board Resolution, and the Trustee may enter into an indenture or indentures supplemental hereto for the purpose of adding any provisions to or changing in any manner or eliminating 

  
 47 

 
any of the provisions of this Indenture, of modifying in any manner the rights of the Holders under this Indenture or waiving any past Default or compliance with any provisions of this Indenture;
provided, however, that no such supplemental indenture shall, without the consent of the Holder of each outstanding Note affected thereby, 
 (a) reduce the amount of the Notes the Holders of which must consent to a supplement to this Indenture; 
 (b) reduce the rate, or extend the stated time for payment, of interest on any Note; 
 (c) reduce the principal, or extend the Stated Maturity, of any Note; 
 (d) make
any change that adversely affects the conversion rights of any Note; 
 (e) reduce any Fundamental Change Repurchase Price or
Redemption Price of any Note or amend or modify in any manner adverse to the Holders of the Notes the Company’s obligation to make such payments, whether through an amendment or waiver of provisions in the covenants, definitions or otherwise;

 (f) change the place or currency of payment of principal or interest in respect of any Note; 

(g) impair the right of any Holder to receive payment of principal of and interest on such Holder’s notes on or after the due dates
therefore or to institute suit for the enforcement of any payment on or with respect to such Holder’s Notes; 
 (h)
adversely affect the ranking of the Notes as the Company’s senior unsecured indebtedness; or 
 (i) make any change in the
amendment provisions which require each Holder’s consent or in the waiver provisions if such change adversely affects the rights of the Holders of the Notes. 
 It shall not be necessary for any Act or consent of Holders under this Section 10.03 to approve the particular form of any proposed supplemental indenture, but it shall be sufficient if such Act or
consent shall approve the substance thereof. The Company may, but shall not be obligated to, fix a record date for the purpose of determining the Persons entitled to consent to any indenture supplemental hereto. If a record date is fixed, the
Holders on such record date, or their duly designated proxies, and only such Persons, shall be entitled to consent to such supplemental indenture, whether or not such Holders remain Holders after such record date; provided that, unless such
consent shall have become effective by virtue of the requisite percentage having been obtained prior to the date which is 90 days after such record date, any such consent 

  
 48 

 
previously given shall automatically and without further action by any Holder be cancelled and of no further effect. 
 Section 10.04. Notices of Supplemental Indentures. After a supplement under this Article 10 becomes effective, the Company will send to the Holders a notice briefly describing the
amendment, supplement or waiver. The Company will send supplemental indentures to Holders upon request. Any failure of the Company to send such notice, or any defect therein, will not, however, in any way impair or affect the validity of
any such supplemental indenture or waiver. 
 ARTICLE 11 

MISCELLANEOUS 
 Section 11.01. Governing Law.  
 This Indenture and the Notes shall
be governed by and construed in accordance with the laws of the State of New York. 
 Section 11.02. Calculations
in Respect of Notes. 
 Except as otherwise provided in this Indenture, the Company shall be responsible for making all
calculations called for hereunder and under the Notes or in connection with a conversion. These calculations include, but are not limited to, determinations of the Last Reported Sales Price, accrued interest payable on the Notes and the Conversion
Rate on the Notes. The Company shall make all these calculations in good faith and, absent manifest error, the Company’s calculations will be final and binding on the Holders. The Company shall provide a schedule of the Company’s
calculations to each of the Trustee and the Conversion Agent, and each of the Trustee and the Conversion Agent is entitled to rely conclusively upon the accuracy of the Company’s calculations without independent verification. The Trustee will
forward the Company’s calculations to any Holder upon the request of such Holder. 
 Section 11.03. No
Representations or Warranties by the Trustee. 
 The Trustee makes no representations or warranties with respect to
the validity or sufficiency of this Supplemental Indenture. 

  
 49 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of
the day and year first above written. 
  

			
	INTERMUNE, INC.
		
	By:	 	   /s/ John C. Hodgman

		 	Name: John C. Hodgman
		 	Title:   SVP & CFO

 [Signature Page to the Supplemental Indenture] 

 
			
	 THE BANK OF NEW YORK MELLON
TRUST COMPANY, N.A.,
as Trustee

		
	By:	 	   /s/ Alex Briffett

		 	Name: John A. (Alex) Briffett
		 	Title:   Senior Associate

 [Signature Page to the Supplemental Indenture] 

 Schedule A 

Make-Whole Table 
 The following table sets forth the hypothetical Stock Prices and the number of Additional Shares to be received by which the Conversion Rate will be increased per $1,000 principal amount of the Notes in
the event of a Make Whole Fundamental Change: 
  

																																																													
	 	  	Stock Price	 
	 Effective Date
	  	 	$24.00	  	  	 	$25.00	  	  	 	$26.00	  	  	 	$27.00	  	  	 	$28.00	  	  	 	$29.00	  	  	 	$30.00	  	  	 	$31.80	  	  	 	$35.00	  	  	 	$40.00	  	  	 	$41.34	  	  	 	$45.00	  	  	 	$50.00	  	  	 	$60.00	  	  	 	$70.00	  
	 September 19,

2011
	  	 	10.2202	  	  	 	9.3809	  	  	 	8.6232	  	  	 	7.9116	  	  	 	7.3194	  	  	 	6.7246	  	  	 	6.2521	  	  	 	5.4289	  	  	 	4.3298	  	  	 	3.1258	  	  	 	2.9007	  	  	 	2.3364	  	  	 	1.7675	  	  	 	1.0576	  	  	 	0.6731	  
	 September 15,

2012
	  	 	10.2202	  	  	 	8.8991	  	  	 	8.1191	  	  	 	7.4131	  	  	 	6.7967	  	  	 	6.2128	  	  	 	5.7467	  	  	 	4.9195	  	  	 	3.8420	  	  	 	2.6612	  	  	 	2.4594	  	  	 	1.9272	  	  	 	1.4167	  	  	 	0.8087	  	  	 	0.4928	  
	 September 15,

2013
	  	 	10.2202	  	  	 	8.4293	  	  	 	7.6055	  	  	 	6.9008	  	  	 	6.2480	  	  	 	5.6497	  	  	 	5.1762	  	  	 	4.3499	  	  	 	3.2557	  	  	 	2.1460	  	  	 	2.0221	  	  	 	1.4771	  	  	 	1.0529	  	  	 	0.5591	  	  	 	0.3302	  
	 September 15,

2014
	  	 	10.2202	  	  	 	7.9934	  	  	 	7.0723	  	  	 	6.3542	  	  	 	5.6437	  	  	 	5.0144	  	  	 	4.5032	  	  	 	3.6553	  	  	 	2.5353	  	  	 	1.4995	  	  	 	1.4640	  	  	 	0.9219	  	  	 	0.6002	  	  	 	0.2743	  	  	 	0.1699	  
	 September 15,

2015
	  	 	10.2202	  	  	 	7.9592	  	  	 	6.9648	  	  	 	6.1201	  	  	 	5.3228	  	  	 	4.5994	  	  	 	3.9833	  	  	 	2.9421	  	  	 	1.5718	  	  	 	0.3168	  	  	 	0.2965	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  
	 September 15,

2016
	  	 	10.2202	  	  	 	8.4027	  	  	 	7.3372	  	  	 	6.3792	  	  	 	5.5484	  	  	 	4.8521	  	  	 	4.1041	  	  	 	3.0706	  	  	 	1.6163	 	  	 	0.1106	  	  	 	0.3291	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  
	 September 15,

2017
	  	 	10.2202	  	  	 	8.6339	  	  	 	7.5307	  	  	 	6.5490	  	  	 	5.6687	  	  	 	4.8769	  	  	 	4.1701	  	  	 	3.0509	  	  	 	1.5844	  	  	 	0.2215	  	  	 	0.0169	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  
	 September 15,

2018
	  	 	10.2202	  	  	 	8.5535	  	  	 	7.0150	  	  	 	5.5905	  	  	 	4.2677	  	  	 	3.0362	  	  	 	1.8868	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  

  
 A-1

 Exhibit A 

[FORM OF FACE OF NOTE] 
 [UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER,
EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS NOTE IS
A GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS NOTE IS EXCHANGEABLE FOR NOTES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS
NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN DEFINITIVE FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE
DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.]1 

 
  

1 This legend is to be included only if the Note is a Global Note. 

  
 A-2

 InterMune, Inc. 

2.50% Convertible Senior Notes due 2018 
  

					
	 No. [            ]
	  	U.S. $	[    	] 

 CUSIP: 45884X AE3 
 ISIN: US45884XAE31 
 InterMune, Inc., a company duly incorporated and validly
existing under the laws of the State of Delaware (herein called the “Company”, which term includes any successor corporation under the Indenture referred to on the reverse hereof), for value received hereby promises to pay to
Cede & Co., or registered assigns, the principal sum of [—] United States Dollars ($[—]) (which amount may from time to time be increased or
decreased by adjustments made on the records of the Trustee, as custodian for the Depositary, in accordance with the rules and procedures of the Depositary and in accordance with the below referred Indenture) on September 15, 2018. 

The issue date of this Note is [—]. 

Reference is made to the further provisions of this Note set forth on the reverse hereof, including, without limitation, provisions
giving the Company the right to redeem this Note under certain circumstances, provisions giving the Holder the right to convert this Note into Common Stock of the Company and to the ability and obligation of the Company to purchase this Note upon
certain events, in each case, on the terms and subject to the limitations referred to on the reverse hereof and as more fully specified in the Indenture. Such further provisions shall for all purposes have the same effect as though fully set forth
at this place. Capitalized terms used but not defined herein shall have such meanings as are ascribed to such terms in the Indenture. 
 This Note shall be deemed to be a contract made under the laws of the State of New York, and for all purposes shall be construed in accordance with and governed by the laws of said State. 

[Signature page follows] 

  
 A-3

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	INTERMUNE, INC.
		
	By:	 	  

		 	Name:
		 	Title:
	Date:	 	

  

			
	 TRUSTEE’S CERTIFICATION OF AUTHENTICATION

 
 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee, certifies that this is
one of the Notes described in the within-mentioned Indenture.
  

	By:	 	  

		 	Name:
		 	Authorized Signatory
	Date:	 	

  
 A-4

 [FORM OF REVERSE SIDE OF NOTE] 

InterMune, Inc. 
 2.50% Convertible Senior Notes due 2018 
 This Note is one of a duly
authorized issue of 2.50% Convertible Senior Notes due 2018 (the “Notes”) of the Company issued under an Indenture, dated as of September 19, 2011 (as amended, modified and supplemented by the First Supplemental Indenture dated
September 19, 2011 (the “First Supplemental Indenture”), the “Indenture”) between the Company and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). The terms of the
Note include those stated in the Indenture, those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (the “TIA”), and those set forth in this Note. This Note is subject to all such terms, and
Holders are referred to the Indenture and the TIA for a statement of all such terms. To the extent permitted by applicable law, if any provision of this Note conflicts with the express provisions of the Indenture, the provisions of the Indenture
shall govern and be controlling. Capitalized terms used but not defined herein have the meanings assigned to them in the Indenture unless otherwise indicated. 
  

	 	1.	Interest. 

 This Note
shall bear interest at a rate of 2.50% per annum on the principal amount. Interest on this Note shall accrue from the date of issuance or from the most recent date to which interest has been paid or duly provided for, as the case may be.
Interest will be payable semi-annually, in arrears, on each March 15 and September 15, beginning on March 15, 2012, to the person in whose name a Note is registered at the Close of Business on the immediately preceding March 1
and September 1, as the case may be. Interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. If a payment date is not a Business Day, payment will be made on the next succeeding Business Day, and no interest
(including Additional Interest, if any) will accrue for the intervening period. 
 Interest (including Additional Interest, if
any) will cease to accrue on the Notes upon their Stated Maturity, conversion, redemption or repurchase by the Company at the option of the Holder upon the occurrence of a Fundamental Change. 

 

	 	2.	Method of Payment. 

Payment of the principal of the Notes shall be made at the office or agency of the Paying Agent, Registrar and Conversion Agent
designated by the Company in such coin or currency of the United States of America as at the time of payment 

  
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is legal tender for payment of public and private debts, in accordance with Section 3.01(c) of the First Supplemental Indenture. 

 

	 	3.	Paying Agent, Registrar and Conversion Agent. 

 Initially, the Trustee will act as Paying Agent, Registrar and Conversion Agent. The Company may change the Paying Agent, Registrar and Conversion Agent without prior notice to the Holders of the Notes.
The Company or any Affiliate of the Company may act as Paying Agent, Registrar or Conversion Agent. 
  

	 	4.	Indenture. 

 The Notes
are general unsecured senior obligations of the Company. The Indenture does not limit the ability of the Company to incur other debt, secured or unsecured. 
  

	 	5.	Redemption at the Option of the Company. 

 The Notes are redeemable in whole, or from time to time in part, at any time on or after September 20, 2015 at the option of the Company if the Last Reported Sale Price of the Common Stock for 20 or
more Trading Days in a period of 30 consecutive Trading Days ending within ten Trading Days immediately prior to the date of the Notice of Redemption exceeds 130% of the applicable Conversion Price in effect on each such Trading Day. The Redemption
Price shall be payable in cash and shall be equal to 100% of the principal amount of Notes being redeemed, plus accrued and unpaid interest (including Additional Interest, if any), if any to, but excluding, the Redemption Date. No sinking fund is
provided for the Notes. 
  

	 	6.	Purchase by the Company at the Option of the Holder Upon a Fundamental Change. 

Subject to the terms and conditions of the Indenture, the Company shall become obligated to purchase, at the option of any Holder, all or
any portion of the Notes held by such Holder upon a Fundamental Change in principal amounts of $1,000 or integral multiples of $1,000 at the Fundamental Change Repurchase Price. To exercise such right, a Holder shall deliver to the Paying Agent, and
the Paying Agent must receive, a Fundamental Change Repurchase Notice containing the information set forth in the Indenture, at any time prior to the Close of Business on the second Scheduled Trading Day immediately preceding the Fundamental Change
Repurchase Date, and shall deliver the Notes to the Paying Agent as set forth in the Indenture. 

  
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 Holders have the right to withdraw (in whole or in part) any Fundamental Change Repurchase
Notice by delivering to the Paying Agent a written notice of withdrawal in accordance with the provisions of the Indenture. 
  

	 	7.	Conversion. 

 Subject to
the provisions of the Indenture (including without limitation the conditions of conversion of Notes set forth in Article 5 of the First Supplemental Indenture), the Holder hereof has the right, at its option, to convert the principal amount hereof
or any portion of such principal which is $1,000 or an integral multiple thereof, into shares of Common Stock and an amount in cash, if any, at the Conversion Rate specified in the Indenture. The initial Conversion Rate is 31.4465 shares of Common
Stock per $1,000 principal amount of Notes (equivalent to an initial Conversion Price of approximately $31.80 per share of Common Stock), subject to adjustment in certain events described in the Indenture. 

Upon conversion, Holders will receive shares of Common Stock and cash, if any, as set forth in the Indenture. 

No fractional shares of Common Stock will be issued upon any conversion. The Company shall make payment of an amount in cash, as provided
in the Indenture, in respect of any fraction of a share of Common Stock which would otherwise be issuable upon the surrender of any Notes for conversion. Notes in respect of which a Holder is exercising its right to require repurchase on a
Fundamental Change Repurchase Date may be converted only if such Holder withdraws its election to exercise such right in accordance with the terms of the Indenture. 
  

	 	8.	Denominations; Transfer; Exchange. 

 The Notes are in fully registered form, without interest coupons, in denominations of $1,000 principal amount and integral multiples of $1,000. A Holder may register the transfer of or exchange Notes in
accordance with the Indenture. The Registrar may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and to pay any taxes, assessments or other governmental charges that may be imposed in relation thereto
by law or permitted by the Indenture. 
  

	 	9.	Unclaimed Money or Securities. 

 The Trustee and the Paying Agent shall return to the Company upon request any cash or securities held by them for the payment of any amount with respect to the Notes that remains unclaimed for two years,
subject to applicable unclaimed property law. After return to the Company, Holders entitled to the cash 

  
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or securities must look to the Company for payment as general creditors unless an applicable abandoned property law designates another Person. 

 

	 	10.	Amendment, Supplement and Waiver. 

 Subject to certain exceptions, the Notes or the Indenture may be amended or supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the Notes then outstanding,
and an existing Default or Event of Default with respect to the Notes and its consequence or compliance with any provision of the Notes or the Indenture may be waived, except in certain circumstances described in the Indenture, with the consent of
the Holders of at least a majority in aggregate principal amount of the Notes then outstanding. Without the consent of or notice to any Holder, the Company and the Trustee may amend or supplement the Indenture or the Notes in the circumstances set
forth in the Indenture. 
  

	 	11.	Defaults and Remedies. 

If any Event of Default other than as a result of certain events of bankruptcy, insolvency or reorganization of the Company occurs and is
continuing, the principal of all the Notes then outstanding plus accrued and unpaid interest (including Additional Interest, if any), may be declared due and payable in the manner and with the effect provided in the Indenture. If an Event of Default
occurs as a result of certain events of bankruptcy, insolvency or reorganization of the Company, the principal amount of the Notes plus accrued and unpaid interest (including Additional Interest, if any) shall become due and payable immediately
without any declaration or other act on the part of the Trustee or any Holder, all to the extent provided in the Indenture. 
  

	 	12.	Authentication. 

 This
Note shall not be valid until the Trustee or an authenticating agent manually signs the certificate of authentication on the other side of this Note. 
  

	 	13.	Abbreviations. 

Customary abbreviations may be used in the name of the Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants
by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian) and UGMA (= Uniform Gifts to Minors Act). 
  

	 	14.	Indenture to Control; Governing Law. 

  
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 To the extent permitted by applicable law, if any provision of this Note conflicts with the
express provisions of the Indenture, the provisions of the Indenture shall govern and be controlling. 
 This Note shall be
governed by, and construed in accordance with, the laws of the State of
 New York. 

  
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 SCHEDULE OF EXCHANGES OF NOTES2 
 The following exchanges, purchases or conversions of a part of this Global Note have been made: 
  

									
	 Date of

Decrease or
 Increase
	  	 Signature of

Authorized

Signatory of
 Trustee or
 Custodian
	  	 Decrease in

Principal

Amount of this
 Global Note
	  	 Increase in

Principal

Amount of this
Global Note
	  	 Principal

Amount of this
 Global Note
 Following Such

Decrease or
 Increase

  

 
 2 This schedule is to be included only if the Note is a Global Note.

  
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 ASSIGNMENT FORM 
 If you want to assign this Note, fill in the form below and have your signature guaranteed: 
 I or we assign and transfer this Note to: 
  

 
  

 
  

 
 (Print or type name, address and zip code and
social security or tax ID number of assignee) 
 and irrevocably appoint
                                         
    agent to transfer this Note on the books of the Company. The agent may substitute another to act for him. 
  

									
	  Date:
                                        
	 		 	Signed:	  	 	  	
		
	    (Sign exactly as your name appears on the other side of this Note)	  	

					
			
	  Signature Guarantee:  	  	 	  	

 Note: Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the
Registrar, which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Registrar in addition to,
or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended. 

  
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 CONVERSION NOTICE 
 If you want to exercise the option to convert this Note in accordance with the terms of the Indenture referred to in this Note, check the box:  ̈ 

To convert only part of this Note, state the principal amount to be converted (which must be $1,000 or a multiple of $1,000, provided
that the portion not so converted is in a minimum principal amount of $1,000): 

$                      
                                         
          
 If you want the share certificate, if any, made out in another
person’s name, fill in the form below: 
  
  

(Insert other person’s social security or tax ID no.) 

 
  
  

 
  
  

 
  
 (Print or type other person’s name, address and zip code) 
  

									
	 Date:
	 	                             
   	  		  	Signed:	  	                             
   

									
	
	 (Sign exactly as your name appears on the other side of this Note)

					
			
	 Signature Guarantee:
	  	  
	  	

 Note: Signatures must be guaranteed by an “eligible guarantor institution” meeting the
requirements of the Registrar, which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the
Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended. 

  
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 FORM OF FUNDAMENTAL CHANGE REPURCHASE NOTICE 

The Bank of New York Mellon Trust Company, N.A. 

700 South Flower Street 
 Los Angeles, California
91007 
 Attention: Corporate Trust Services 
  

	 	Re:	InterMune, Inc. (the “Company”) 

 2.50% Convertible Senior Notes due 2018 
 This is a Fundamental Change
Repurchase Notice as defined in Section 4.01(a) of the First Supplemental Indenture, dated as of September 19, 2011, between the Company and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”) (the
“First Supplemental Indenture” and the Base Indenture, dated as of September 19, 2011, between the Company and the Trustee, as amended, modified and supplemented by the First Supplemental Indenture, the
“Indenture”). Terms used but not defined herein shall have the meanings ascribed to them in the Indenture. 
 Certificate
No(s). of Notes:
                                         
                    
 I
intend to deliver the following aggregate principal amount of Notes for purchase by the Company pursuant to Article 4 of the First Supplemental Indenture (integral multiples of $1,000 with a minimum of $1,000): 

$
                                 

I hereby agree that the Notes will be purchased on the Fundamental Change Repurchase Date pursuant to the terms and conditions specified
in the Notes and in the Indenture. 
  

			
	 Signed:

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