Document:

Exhibit 10.3

 

BIO-PATH HOLDINGS, INC.

2022 STOCK INCENTIVE PLAN

 

NON-QUALIFIED STOCK OPTION
AWARD AGREEMENT

 

This Non-Qualified Stock Option
Award Agreement (the “Agreement”) is made and entered into as of the award date set forth below (the “Award
Date”) by and between Bio-Path Holdings, Inc., a Delaware corporation (the “Company”), and the
participant named below (the “Participant”). Capitalized terms not defined herein shall have the meaning ascribed
to them in the Company’s 2022 Stock Incentive Plan (the “Plan”).

 

Participant: ___________________________________

 

Total Award Shares: ______
Shares

 

Exercise Price Per Share:
$__________/Share

 

Award Date: ______ ___,
20__

 

Expiration Date: _______
___, 20__

 

Section 1.             Grant of Award. The Company hereby grants to
Participant Non-Qualified Stock Options (this “Award”) to purchase the total number of Shares of the Company
set forth above as Total Award Shares (the “Shares”) at the Exercise Price Per Share set forth above (the “Exercise
Price”), subject to all of the terms and conditions of this Agreement and the Plan. These stock options (the “Stock
Options”) are not intended to qualify as “incentive stock options” under Code Section 422.

 

Section 2.             Vesting Schedule. The Award shall initially be
unvested and unexercisable. The Award shall become exercisable upon vesting in accordance with the following schedule, provided the Participant
is in Continuous Service with the Company (or an Affiliate) on the applicable Vesting Date. The Award shall vest over a four-year period,
with one-fourth (1/4) of the Shares vesting on the first anniversary hereof (i.e., approximately [___] Shares) and the remaining Shares
vesting thereafter in equal monthly increments equal to one-forty-eighth (1/48) of the Shares (i.e., approximately [___] Shares per month)(each
such date, a “Vesting Date”).

 

Notwithstanding the foregoing,
the Plan Administrator may, in its sole discretion, provide that the vesting of any or all Stock Options granted pursuant to this Agreement
will accelerate immediately prior to the consummation of a Change in Control, provided the Participant remains in Continuous Service as
of such date. If the Plan Administrator exercises such discretion with respect to the Stock Options, the Stock Options will become exercisable
to the extent provided by the Plan Administrator prior to the consummation of the Change in Control at such time and on such conditions
as the Plan Administrator determines, and any vested Stock Options not exercised prior to the consummation of such event shall terminate
at such time as determined by the Plan Administrator.

 

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Section 3.              Exercise of Stock Options. Each Stock Option
shall be exercisable during the Award Term to the extent provided under this Section 3.

 

3.1           Exercise Period.

 

(i)            Voluntary Termination of Service. In the event Participant is terminated for any reason (other than upon Participant’s
death, Disability, Retirement by a Director, or for Cause, or upon occurrence of a Breach Event), Participant may thereafter exercise
the vested portion of this Award (to the extent that Participant was entitled to exercise this Award as of the Termination Date) but only
within such period of time ending on the earlier of (A) the date that is three (3) months following Participant’s Termination Date
and (B) the Expiration Date. If, after termination, Participant does not exercise this Award within the time specified herein, this Award
shall terminate and will no longer be exercisable.

 

(ii)           Death of Participant. In the event Participant is terminated by reason of Participant’s death, Participant’s
estate, heirs or designated beneficiary, as applicable, may thereafter exercise this Award (to the extent that Participant was entitled
to exercise this Award as of the Termination Date) but only within such period of time ending on the earlier of (A) twelve (12) months
following the Participant’s death and (B) the Expiration Date. If, after Participant’s death, Participant’s estate,
heirs or designated beneficiary has not exercised this Award within the time specified herein, this Award shall terminate and will no
longer be exercisable.

 

(iii)          Disability of Participant. In the event Participant is terminated by reason of Participant’s Disability, Participant
(or his legal representative) may thereafter exercise this Award (to the extent that Participant was entitled to exercise this Award as
of the Termination Date) but only within such period of time ending on the earlier of (A) twelve (12) months following the Participant’s
Termination Date and (B) the Expiration Date. If, after termination, Participant, or his legal representative, has not exercised this
Award within the time specified herein, this Award shall terminate and will no longer be exercisable.

 

(iv)          Termination for Cause or Occurrence of a Breach Event. Notwithstanding any provision herein to the contrary, in the event
Participant is terminated for Cause or upon the occurrence of a Breach Event, this Stock Option, whether or not vested, shall immediately
terminate and will no longer be exercisable.

 

(v)           Retirement of Director. In the event of the Retirement of a Participant who is a Director, such Participant shall be entitled
to exercise this Award (to the extent that Participant was entitled to exercise this Award as of the date of Retirement) until the Expiration
Date.

 

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(vi)          Expiration of Stock Option. This Award will expire on the Expiration Date set forth above, or earlier as provided in this
Agreement or the Plan.

 

3.2           Manner of Exercise.

 

(i)            Stock Option Exercise Agreement. To exercise this Award, Participant (or his legal representative, estate, heirs, or designated
beneficiary, as the case may be) must deliver to the Company an executed Exercise Agreement in the form attached hereto as Appendix
I, and, if applicable, spousal consent, and such other documents as may be required by the Company and the Plan Administrator. If
someone other than Participant exercises this Stock Option, then such person must submit documentation reasonably acceptable to the Company
verifying that such person has the legal right to exercise this Award under the Plan. The Award shall be deemed exercised as of the date:
(i) the Company receives (A) the fully executed Exercise Agreement, including spousal consent if applicable and (B) payment of the aggregate
Exercise Price, and (ii) all other applicable terms and conditions of this Agreement and the Plan are satisfied including applicable tax
withholding), as determined in the sole discretion of the Plan Administrator.

 

(ii)           Limitations on Exercise. This Award must be exercised in whole Shares and may not be exercised for less than one (1) Share.

 

(iii)          Payment. Except as otherwise permitted by the Plan Administrator, the Exercise Price for the Shares being purchased and
the amount of the applicable federal, state and local tax withholding imposed upon exercise of this Stock Option may be paid pursuant
to the following methods:

 

(A)          by cash, wire transfer, certified check or bank draft;

 

(B)           by execution of a promissory note, to be submitted with a stock power, endorsed in blank relating to the Shares held as collateral
for such note;

 

(C)           by “net exercise”, pursuant to which the Company withholds from the Shares that would otherwise be issued upon exercise
of an Award that number of Shares with a Fair Market Value equal to the Exercise Price for the Award;

 

(D)           through a broker-dealer acting on behalf of Participant if (i) the broker-dealer has received a fully and duly endorsed copy of
the Award Agreement and a fully and duly endorsed notice of exercise or purchase, along with written instructions signed by Participant
requesting that the Company deliver Shares to the broker-dealer to be held in a designated account on behalf of Participant; (ii) adequate
provision has been made with respect to the payment of any withholding taxes due upon grant, exercise, or vesting; and (iii) the broker-dealer
and Participant have otherwise complied with applicable securities laws;

 

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(E)           through the delivery of unrestricted Shares having a Fair Market Value equal to the Exercise Price and owned by Participant for
more than six (6) months (or such shorter or longer period of time as is necessary to avoid a charge to earnings on the Company’s
financial statements) or that otherwise meet the conditions established by the Company to avoid adverse accounting consequences (as determined
by the Company);

 

(F)           by any combination of the foregoing or other methods authorized by the Plan Administrator.

 

(iv)          Issuance of Shares. Upon satisfaction of the foregoing provisions of this subsection 3.2, Participant shall
become a stockholder of record. The Company may, but is not required to, issue certificated Shares registered in the name of Participant,
which may include the appropriate legends affixed thereto.

 

Section
4.              Consent
of Spouse. If the Participant is married as of the date of this Agreement, the Participant’s spouse shall
execute and deliver to the Company a Consent of Spouse in the form attached hereto as Appendix II, effective on the date hereof.
Notwithstanding the execution and delivery thereof, such consent shall not be deemed to confer or convey to the spouse any rights in the
Restricted Shares that do not otherwise exist by operation of law or the agreement of the parties.
If the Participant should marry or remarry subsequent to the date of this Agreement, the Participant shall within 60 days thereafter obtain
his or her new spouse’s acknowledgement of and consent to the existence and binding effect of all restrictions contained in this
Agreement by such spouse’s executing and delivering a Consent of Spouse in the form of Appendix II.

 

Section 5.              Restrictions on Transfer. Absent the written
approval of the Plan Administrator, the Award may not be transferred in any manner other than by will or by the laws of descent and distribution
and, during the lifetime of Participant, only Participant (or, in the event of Participant’s incapacity, Participant’s legal
representative) may exercise this Stock Option.

 

Section 6.              No Obligation to Employ. Nothing in the Plan
or this Agreement shall confer on Participant any right to continue in the employ of, or other relationship with, the Company or any Affiliate,
or limit in any way the right of the Company or any Affiliate to terminate Participant’s employment or other relationship at any
time, with or without Cause.

 

Section 7.              Rights as a Stockholder. Participant shall not
have any of the rights of a stockholder as a result of the grant of this Award or the vesting of the Stock Options. Upon exercise of vested
Stock Options, Participant shall become a stockholder of record and will have all of the rights of a stockholder of the Company with respect
to the Shares from and after the date that Shares are issued to Participant until such time as Participant disposes of the Shares. No
adjustment shall be made for dividends or other rights for which the record date is prior to the date on which the SARs are exercised.

 

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Section 8.              Compliance with Laws and Regulations. The exercise
of a Stock Option and the issuance and transfer of Shares shall be subject to compliance by the Company and Participant with all applicable
requirements of federal and state securities laws and with all applicable requirements of any stock exchange on which the Company’s
Common Stock may be listed at the time of such issuance or transfer.

 

Section 9.              Tax Consequences. Set forth below is a brief
summary as of the effective date of the Plan of some of the federal and state tax consequences upon exercise of a Stock Option and disposition
of the Shares. THIS SUMMARY IS NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. PARTICIPANT SHOULD CONSULT
A TAX ADVISOR.9.1 

 

9.1           Grant of Award. There will be no regular federal or state income tax liability upon the grant of the Award.

 

9.2           Vesting of Award. There will be no regular federal or state income tax liability upon vesting of the Award. However, there
may be federal and state employment taxes due upon vesting of the Award.

 

9.3           Exercise of Stock Option. There may be regular U.S. Federal and state income tax liability upon the exercise of this Stock
Option. Participant will be treated as having received compensation income (taxable at ordinary income tax rates) equal to the excess,
if any, of the Fair Market Value of the Shares on the date of exercise over the Exercise Price. If Participant is a current or former
employee of the Company or a Subsidiary or an Affiliate, the Company or such Subsidiary or Affiliate may be required to withhold from
Participant’s compensation or collect from Participant and pay to the applicable taxing authorities an amount equal to a percentage
of this compensation income at the time of exercise.

 

9.4           Disposition of Shares. If the Shares are held for one (1) year or less following the date of the purchase of the Shares
pursuant to the exercise of this Stock Option, any gain realized on disposition of the Shares will be treated as short-term capital gain.
If the Shares are held for more than one (1) year after the date of the purchase of the Shares pursuant to the exercise of this Stock
Option, any gain realized on disposition of the Shares will be treated as long-term capital gain.

 

9.5           Tax Liability and Withholding. Notwithstanding any action the Company takes with respect to any or all income tax, social
security, payroll tax, or other tax-related withholding (“Tax-Related Items”), the ultimate liability for all
Tax-Related Items is and remains the Participant’s responsibility and the Company (i) makes no representation or undertakings regarding
the treatment of any Tax-Related Items in connection with the grant, vesting, or exercise of the Stock Options under this Award or the
subsequent sale of any Shares acquired upon exercise of a Stock Option; and (ii) does not commit to structure this Award to reduce or
eliminate the Participant’s liability for Tax-Related Items.

 

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Section 10.           Notices. Any notice required to be given or delivered
to the Plan Administrator or the Company under the terms of this Agreement shall be in writing (including a writing delivered by facsimile
transmission or electronic mail) and addressed to the Plan Administrator at the principal corporate office of the Company. Any notice
required to be given or delivered to Participant shall be in writing (including a writing delivered by facsimile transmission or electronic
mail) and addressed to Participant at the address indicated above or to such other address as such party may designate in writing from
time to time to the Plan Administrator. All notices shall be deemed to have been given or delivered upon: (a) personal delivery; (b) five
(5) days after deposit in the United States mail by certified or registered mail (return receipt requested); (c) one (1) business day
after deposit with any return receipt express courier (prepaid); or (d) when receipt is acknowledged after transmission by facsimile or
electronic mail.

 

Section 11.           Interpretation. Any dispute regarding the interpretation
of this Agreement shall be resolved by the Plan Administrator, which decision shall be final and binding on the Company and Participant.
In the event of an ambiguity, the Plan Administrator shall, to the extent necessary, interpret this Agreement in a manner that is intended
to ensure that the Award is exempt from or compliant with Code Section 409A.

 

Section 12.            Successors and Assigns. The Company may assign
any of its rights under this Agreement. This Agreement shall be binding upon and inure to the benefit of the successors and assigns of
the Company. Subject to applicable restrictions on transfer, this Agreement shall be binding upon Participant and Participant’s
heirs, executors, administrators, legal representatives and designated beneficiary.

 

Section 13.            Governing Law. To the extent not otherwise preempted
by federal law, the validity, construction and effect of this Agreement shall be governed by and construed in accordance with the laws
of the State of Delaware, without giving effect to its conflict of law principles.

 

Section 14.            Choice of Forum. Participant hereby irrevocably
and unconditionally submits, for itself and its property, to the exclusive jurisdiction of the state courts of Delaware (and if jurisdiction
in the state courts of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware),
and any appellate court from any thereof, in any action or proceeding arising out of or relating to this Exercise Agreement, the Shares
issued in connection herewith or for recognition or enforcement of any judgment relating thereto, and Participant hereby (i) agrees not
commence any such action or proceeding except in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall
be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), (ii) agrees that any claim in respect
of any such action or proceeding may be heard and determined in the state courts of Delaware (and if jurisdiction in the state courts
of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), and any appellate
court from any thereof, (iii) waives, to the fullest extent it may legally and effectively do so, any objection which it may now or hereafter
have to the laying of venue of any such action or proceeding in the state courts of Delaware (and if jurisdiction in the state courts
of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), and (iv) waives,
to the fullest extent it may legally and effectively do so, the defense of an inconvenient forum to the maintenance of such action or
proceeding in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts
of the United States of America sitting in the state of Delaware).

 

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Section 15.           Waiver of Jury Trial. EACH
OF THE PARTIES HERETO IRREVOCABLY AND UNCONDITIONALLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR PROCEEDING RELATING
TO A DISPUTE ARISING OUT OF OR RELATING TO THIS EXERCISE AGREEMENT AND FOR ANY COUNTERCLAIM WITH RESPECT THERETO.

 

Section 16.           Amendment of Award. The Plan Administrator may
amend, modify or terminate this Agreement at any time prior to payment or exercise in any manner not inconsistent with the terms of this
Plan; provided, however, that Participant’s rights under this Award shall not be impaired by such amendment unless (i) Participant
consents in writing or (ii) the Plan Administrator determines that the amendment is required to ensure that the Award is exempt from or
compliant with Code Section 409A.

 

Section 17.           Counterparts. This Agreement may be executed
in counterparts, each of which shall be deemed an original but all of which together will constitute one and the same instrument. Counterpart
signature pages to this Agreement transmitted by facsimile transmission, by electronic mail in portable document format (.pdf), or by
any other electronic means intended to preserve the original graphic and pictorial appearance of a document, will have the same effect
as physical delivery of the paper document bearing an original signature.

 

Section 18.           Discretionary Nature of Plan.
The grant of this Award does not create any contractual right or other right to receive any Awards in the future. Future Awards, if any,
will be at the sole discretion of the Plan Administrator. Any amendment, modification, or termination of the Plan shall not constitute
a change or impairment of the terms and conditions of the Participant’s employment or other service relationship with the Company
(or any Subsidiary or Affiliate).

 

Section 19.           Severability. If any provision of this Agreement
is determined by a court of law to be illegal or unenforceable, then such provision will be enforced to the maximum extent possible and
the other provisions will remain fully effective and enforceable.

 

Section 20.           Further Instruments. The parties agree to execute
such further instruments and to take such further action as may be reasonably necessary to carry out the purposes and intent of this Award
Agreement.

 

Section 21.           Headings. The captions and headings of this Agreement
are included for ease of reference only and will be disregarded in interpreting or construing this Agreement.

 

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Section 22.           Gender and Number. In construing this Agreement,
any masculine terminology herein shall also include the feminine, and the definition of any term herein in the singular shall also include
the plural, except when otherwise indicated by the context.

 

Section 23.           Entire Agreement. The Plan is incorporated herein
by reference. This Agreement and the Plan constitute the entire agreement of the parties and supersede all prior undertakings and agreements
with respect to the subject matter hereof. If any inconsistency should exist between the nondiscretionary terms and conditions of this
Agreement and the Plan, the Plan shall govern and control.

 

Section 24.           Acceptance. Participant hereby acknowledges that
he has read and understands the terms and provisions of this Agreement, and accepts the Award subject to all the terms and conditions
of the Plan and this Agreement. Participant has had an opportunity to obtain the advice of legal counsel prior to executing this Agreement.
Participant acknowledges that there may be adverse tax consequences upon exercise of this Award and disposition of the Shares, and that
Participant should consult a tax advisor prior to such exercise or disposition. Participant attests that he is relying solely on such
advisors and not on any statements or representations of the Plan Administrator, the Company, or any Affiliate, or any agents thereof.
Further, Participant hereby acknowledges and understands that he (and not the Company) shall be solely responsible for his tax liability
that may arise as a result of receiving this Award Agreement.

 

 

[Remainder of Page Intentionally Left Blank]

 

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IN WITNESS WHEREOF, the Company
and Participant have caused this Agreement to be executed in duplicate, effective as of the Award Date.

 

	 	BIO-PATH HOLDINGS, INC.
	 	 
	 	 
	 	By:	                     
	 	 	 
	 	(Please print name)
	 	 
	 	 
	 	(Please print title)
	 	 
	 	PARTICIPANT 
	 	 
	 	 
	 	 
	 	(Signature)
	 	 
	 	(Please print name)
	 	 
	 	Address:
	 	 
	 	 

	 	Facsimile:	 
	 	E-mail:	 

 

 

[Signature Page to Non-Qualified Stock Option Award Agreement]

 

    

     

    

 

APPENDIX I

 

NON-QUALIFIED STOCK OPTION EXERCISE AGREEMENT

 

BIO-PATH HOLDINGS, INC.

2022 STOCK INCENTIVE PLAN

 

NON-QUALIFIED STOCK OPTION EXERCISE AGREEMENT

 

This Non-Qualified
Stock Option Exercise Agreement (the “Exercise Agreement”) is made and entered into as of _____________________
(the “Effective Date”) by and between Bio-Path Holdings, Inc., a Delaware corporation (the “Company”),
and the individual named below (the “Participant”) pursuant to the Bio-Path Holdings, Inc., 2022 Stock Incentive
Plan (the “Plan”). Capitalized terms not defined herein shall have the meanings ascribed to them in the Plan
or this Award Agreement.

 

Participant: _________________________

 

Social Security Number: _______________

 

Address:                  ____________________

 

    ______________________

 

Email: _______________________________________

 

Telephone Number: _____________________________

 

Fax Number: __________________________________

 

Total Shares to be Purchased:
[________]

 

Per Share Exercise Price:
[___________]

 

Aggregate Exercise Price:
[___________]

 

Award Date: [______________________]

 

Expiration Date: [_________________________]

 

 

 

1.             Exercise of Stock Options.

 

1.1           Exercise. Pursuant to the exercise of those certain stock options (the “Stock Options”) granted
to Participant under the Plan and the applicable Award Agreement and subject to the terms and conditions of this Exercise Agreement, Participant
hereby purchases from the Company, and the Company hereby sells to Participant, the Total Shares to be Purchased set forth above (the
 “Shares”) for the Aggregate Exercise Price set forth above.

 

    APPENDIX I - 1

     

    

 

1.2           Payment. Participant hereby delivers payment of the Exercise Price in a form permitted under the applicable Award Agreement
and the terms of the Plan, in the amount of $_________________, receipt of which is acknowledged by the Company.

 

2.             Delivery.

 

2.1           Deliveries by Participant. Participant hereby delivers to the Plan Administrator (a) this Exercise Agreement,
executed by the Participant, (b) the Exercise Price for the purchase of the Total Shares set forth above and payment or other provision
for any applicable tax obligations in the form of a check or other method permitted under the applicable Award Agreement and the terms
of the Plan, and (c) such other documents as required by the Company or Plan Administrator.

 

2.2           Shares Issued. Upon receipt of the items described in Section 2.1, the Company shall evidence the issuance of the
Shares to the Participant. If the Company desires to evidence these Shares by means of certificated shares, the Company shall issue a
certificate in the name of Participant for the number of Shares purchased upon exercise of the Stock Option in accordance with this Exercise
Agreement.

 

3.             Rights as a Stockholder. Upon becoming a stockholder
of record, Participant will have all of the rights of a stockholder of the Company with respect to the Shares from and after the date
that Shares are issued to Participant until such time as Participant disposes of the Shares.

 

4.             Compliance with Laws and Regulations. The
issuance and transfer of the Shares will be subject to, and conditioned upon compliance by the Company and the Participant with, all applicable
federal, state and local laws and regulations and all applicable requirements of any stock exchange or automated quotation system on which
the Shares may be listed or quoted at the time of such issuance or transfer.

 

5.             Tax Consequences. Set forth below is a brief
summary as of the effective date of the Plan of some of the federal and state tax consequences of exercise of a Stock Option and disposition
of the Shares. THIS SUMMARY IS NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. RECIPIENT SHOULD CONSULT
A TAX ADVISOR BEFORE EXERCISING A STOCK OPTION OR DISPOSING OF THE SHARES.

 

5.1           Exercise of Stock Option. There may be regular federal and state income tax liability upon the exercise of this Stock Option.
Participant will be treated as having received compensation income (taxable at ordinary income tax rates) equal to the excess, if any,
of the Fair Market Value of the Shares on the date of exercise over the Exercise Price. If Participant is a current or former employee
of the Company or an Affiliate, the Company or such Affiliate may be required to withhold from Participant’s compensation or collect
from Participant and pay to the applicable taxing authorities an amount equal to a percentage of this compensation income at the time
of exercise.

 

    APPENDIX I - 2

     

    

 

5.2           Disposition of Shares. If the Shares are held for one (1) year or less following the date of the purchase of the
Shares pursuant to the exercise of this Stock Option, any gain realized on disposition of the Shares will be treated as short-term capital
gain. If the Shares are held for more than one (1) year after the date of the purchase of the Shares pursuant to the exercise of this
Stock Option, any gain realized on disposition of the Shares will be treated as long-term capital gain.

 

5.3           Tax
Liability and Withholding. Notwithstanding any action the Company takes with respect to any or all income tax, social security, payroll
tax, or other tax-related withholding (“Tax-Related Items”), the ultimate liability for all Tax-Related Items
is and remains the Participant’s responsibility and the Company (a) makes no representation or undertakings regarding the treatment
of any Tax-Related Items in connection with the grant, vesting, or exercise of this Stock Option or the subsequent sale of any Shares
acquired upon exercise of this Stock Option; and (b) does not commit to structure this Stock Option to reduce or eliminate the Participant’s
liability for Tax-Related Items.

 

6.             Notices. Any notice required to be given or delivered
to the Plan Administrator or the Company under the terms of this Exercise Agreement shall be in writing (including a writing delivered
by facsimile transmission or electronic mail) and addressed to the Plan Administrator at the principal corporate office of the Company.
Any notice required to be given or delivered to Participant shall be in writing (including a writing delivered by facsimile transmission
or electronic mail) and addressed to Participant at the address indicated above or to such other address as such party may designate in
writing from time to time to the Plan Administrator. All notices shall be deemed to have been given or delivered upon: (a) personal delivery;
(b) five (5) days after deposit in the United States mail by certified or registered mail (return receipt requested); (c) one (1) business
day after deposit with any return receipt express courier (prepaid); or (d) when receipt is acknowledged after transmission by facsimile
or electronic mail.

 

7.             Interpretation. Any dispute regarding the interpretation
of this Exercise Agreement shall be resolved by the Plan Administrator, which decision shall be final and binding on the Company and Participant.

 

8.             Successors and Assigns. The Company may assign
any of its rights under this Exercise Agreement. This Exercise Agreement shall be binding upon and inure to the benefit of the successors
and assigns of the Company. Subject to applicable restrictions on transfer, this Exercise Agreement shall be binding upon Participant
and Participant’s heirs, executors, administrators, legal representatives and designated beneficiary.

 

9.             Governing Law. TO THE EXTENT NOT OTHERWISE PREEMPTED
BY FEDERAL LAW, THE VALIDITY, CONSTRUCTION AND EFFECT OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS
OF THE STATE OF DELAWARE, WITHOUT GIVING EFFECT TO ITS CONFLICT OF LAW PRINCIPLES.

 

    APPENDIX I - 3

     

    

 

10.          Choice of Forum. Participant hereby irrevocably
and unconditionally submits, for itself and its property, to the exclusive jurisdiction of the state courts of Delaware (and if jurisdiction
in the state courts of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware),
and any appellate court from any thereof, in any action or proceeding arising out of or relating to this Exercise Agreement, the Shares
issued in connection herewith or for recognition or enforcement of any judgment relating thereto, and Participant hereby (i) agrees not
commence any such action or proceeding except in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall
be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), (ii) agrees that any claim in respect
of any such action or proceeding may be heard and determined in the state courts of Delaware (and if jurisdiction in the state courts
of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), and any appellate
court from any thereof, (iii) waives, to the fullest extent it may legally and effectively do so, any objection which it may now or hereafter
have to the laying of venue of any such action or proceeding in the state courts of Delaware (and if jurisdiction in the state courts
of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware), and (iv) waives,
to the fullest extent it may legally and effectively do so, the defense of an inconvenient forum to the maintenance of such action or
proceeding in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts
of the United States of America sitting in the state of Delaware).

 

11.          Waiver of Jury Trial. EACH OF THE PARTIES HERETO
IRREVOCABLY AND UNCONDITIONALLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR PROCEEDING RELATING TO A DISPUTE ARISING OUT
OF OR RELATING TO THIS EXERCISE AGREEMENT AND FOR ANY COUNTERCLAIM WITH RESPECT THERETO.

 

12.          Counterparts. This Exercise Agreement may be
executed in counterparts, each of which shall be deemed an original but all of which together will constitute one and the same instrument.
Counterpart signature pages to this Agreement transmitted by facsimile transmission, by electronic mail in portable document format (.pdf),
or by any other electronic means intended to preserve the original graphic and pictorial appearance of a document, will have the same
effect as physical delivery of the paper document bearing an original signature.

 

13.          Severability. If any provision of this Exercise
Agreement is determined by a court of law to be illegal or unenforceable, then such provision will be enforced to the maximum extent possible
and the other provisions will remain fully effective and enforceable.

 

14.          Further Instruments. The parties agree to execute
such further instruments and to take such further action as may be reasonably necessary to carry out the purposes and intent of this Award
Agreement.

 

15.          Headings. The captions and headings of this Exercise
Agreement are included for ease of reference only and will be disregarded in interpreting or construing this Exercise Agreement.

 

    APPENDIX I - 4

     

    

 

16.          Gender and Number. In construing this Exercise
Agreement, any masculine terminology herein shall also include the feminine, and the definition of any term herein in the singular shall
also include the plural, except when otherwise indicated by the context.

 

17.          Entire Agreement. The Plan is incorporated herein
by reference. This Exercise Agreement, the Award Agreement, and the Plan constitute the entire agreement of the parties and supersede
all prior undertakings and agreements with respect to the subject matter hereof. If any inconsistency should exist between the nondiscretionary
terms and conditions of this Exercise Agreement and the Plan, the Plan shall govern and control.

 

    APPENDIX I - 5

     

    

 

IN WITNESS WHEREOF, the Company
and the Participant have caused this Exercise Agreement to be executed in duplicate as of the Effective Date first above written.

 

	 	BIO-PATH HOLDINGS, INC.
	 	 
	 	 
	 	By:	           
	 	 
	 	 
	 	(Please print name)
	 	 
	 	(Please print title)
	 	 
	 	 
	 	PARTICIPANT
	 	 
	 	 
	 	 
	 	(Signature)
	 	 
	 	(Please print name)

 

    APPENDIX I - 6

     

    

 

APPENDIX II

 

CONSENT OF SPOUSE TO AWARD AGREEMENT

 

I, ______________________,
the spouse of Participant (as defined in the Bio-Path Holdings, Inc. 2022 Stock Incentive Plan Award Agreement to which this consent is
attached), have read, understand, and hereby approve all the terms and conditions of (a) such Award Agreement to which this consent is
attached and (b) the Plan (as defined therein).

 

I hereby agree to be irrevocably
bound by all the terms and conditions of Bio-Path Holdings, Inc. 2022 Stock Incentive Plan Award Agreement and the Plan and further agree
that any community property interest I may have in the Award or any Common Stock that is ultimately held by Participant will be similarly
bound by the Bio-Path Holdings, Inc. 2022 Stock Incentive Plan Award Agreement and the Plan.

 

I hereby appoint Participant,
with unrestricted power of substitution and resubstitution, as my attorney-in-fact, to act in my name, place, and stead with respect to
any amendment of the Bio-Path Holdings, Inc. 2022 Stock Incentive Plan Award Agreement or the Plan or the exercise of any rights or satisfaction
of any obligations thereunder. This grant of power of attorney is irrevocable, shall not be affected by my subsequent death, disability
or incapacity, is binding upon each of my legatees, heirs, personal representatives and administrators and is coupled with an interest.

 

Dated: ___________ ___, _____

 

 

	 	Signature:	 

 

    APPENDIX II - 1Exhibit 10.4

 

BIO-PATH HOLDINGS, INC.

2022 STOCK INCENTIVE PLAN

 

RESTRICTED SHARE UNIT AWARD AGREEMENT

 

This Restricted Share Unit Award Agreement (the
 “Agreement”) is made and entered into as of the award date set forth below (the “Award Date”)
by and between Bio-Path Holdings, Inc., a Delaware corporation (the “Company”), and the participant named below
(the “Participant”). Capitalized terms not defined herein shall have the meaning ascribed to them in the Company’s
2022 Stock Incentive Plan (the “Plan”).

 

	Participant:	 	 

 

	Award Date:	 	 

 

	Number of Restricted Stock Units:	 	 

 

1.             Award of Restricted Share Units. The Company hereby issues to Participant an Award of the Number of Restricted Share
Units set forth above (the “RSUs”), subject to the terms and conditions set forth in this Agreement. An RSU
represents an unfunded, unsecured right to receive a Share of Common Stock of the Company or cash equal to the Fair Market Value of a
Share.

 

2.             Restrictions on RSUs. Except as otherwise provided in the Plan and this Agreement, the restrictions on Participant’s
unvested RSUs are that the RSUs shall be subject to forfeiture by Participant if Participant fails to satisfy the vesting conditions set
forth below.

 

3.             Vesting of RSUs. The RSUs awarded hereunder shall vest, and the restrictions on such RSUs shall lapse, only if Participant
remains in Continuous Service with the Company or an Affiliate until the applicable anniversary of the Award Date, as set forth below
(each, a “Vesting Date”):  

 

	Vesting Percentage	Vesting Date
	 	 
	 	 
	 	 
	 	 

Notwithstanding the foregoing, a Participant who
dies or becomes Disabled shall become immediately 100% vested in the RSUs. Furthermore, the Plan Administrator may, in its sole discretion,
provide that the restrictions on all or any portion of the outstanding RSUs granted pursuant to this Agreement will immediately lapse
prior to the consummation of a Change in Control. If the Plan Administrator exercises such discretion with respect to the RSUs, the vested
RSUs will be settled prior to the consummation of the Change in Control at such time and on such conditions as the Plan Administrator
determines.

 

    1

     

    

 

4.             Settlement of RSUs. Each vested RSU shall be settled during the period beginning on the applicable Vesting Date and
ending on the later of: (a) the last day of the calendar year in which such Vesting Date occurs or (b) March 15th of the calendar
year following the end of the calendar year in which such Vesting Date occurs (the “Settlement Date”). The Company
will settle vested RSUs by issuing to Participant, on a one-for-one basis, Shares of Common Stock of the Company or cash equal to the
Fair Market Value of such Shares. In no event shall Participant be permitted to designate the taxable year in which settlement of an RSU
shall occur.

 

5.             Restrictions on Transfer. Participant may not sell, assign, pledge as security or otherwise transfer or encumber the
unvested RSUs, whether voluntary or involuntary, and if involuntary, whether by process of law in any civil or criminal suit, action or
proceeding, whether in the nature of an insolvency or bankruptcy proceeding or otherwise.

 

6.             No Obligation to Employ. Nothing in the Plan or this Agreement shall confer on Participant any right to continue in
the employ of, or other relationship with, the Company or any Affiliate, or limit in any way the right of the Company, or as applicable,
an Affiliate to terminate Participant's employment or other relationship at any time, with or without Cause.

 

7.             Rights as a Stockholder. Participant shall not have any rights of a stockholder as a result of the grant of this Award
or the vesting of the RSUs. If Shares are issued upon settlement of vested RSUs, Participant shall become a stockholder of record and
will have all of the rights of a stockholder of the Company with respect to the Shares from and after the date that Shares are issued
to Participant until such time as Participant disposes of the Shares.

 

8.             Compliance with Laws and Regulations. Notwithstanding any other provision of the Plan or the Agreement to the contrary,
the grant, vesting and holding of the Shares by Participant is expressly conditioned upon compliance with the Securities Act and all applicable
state securities laws. Participant agrees to cooperate with the Company to ensure compliance with such laws.

 

9.             Tax Consequences. Set forth below is a brief summary as of the effective date of the Plan of some of the federal and
state tax consequences of the grant and vesting of the RSU and, where applicable, the disposition of the Shares. THIS SUMMARY IS NECESSARILY
INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE. RECIPIENT SHOULD CONSULT A TAX ADVISOR BEFORE ACCEPTING THIS AWARD.

 

9.1           Grant of Award. There will be no regular federal or state income tax liability upon the grant of the Award.

 

9.2           Vesting of Award. There will be no regular federal or state income tax liability upon vesting of the Award. However, there
may be federal and state employment taxes due upon vesting of the Award.

 

9.3           Settlement of Award. There may be regular federal and state income tax liability upon settlement of the Award. Participant
will be treated as having received compensation income (taxable at ordinary income tax rates) equal to the cash or Fair Market Value of
the Shares issued to Participant. If Participant is a current or former employee of the Company or an Affiliate, the Company or such Affiliate
may be required to withhold from Participant’s compensation or collect from Participant and pay to the applicable taxing authorities
an amount equal to a percentage of this compensation income at the time of settlement.

 

    2

     

    

 

9.4           Disposition of Shares. If Shares are issued to Participant and the Shares are held for one (1) year or less
following the Settlement Date, any gain realized on disposition of the Shares will be treated as short-term capital gain. If the Shares
are held for more than one (1) year following the Settlement Date, any gain realized on disposition of the Shares will be treated as long-term
capital gain.

 

9.5           Tax Liability and Withholding. Notwithstanding any action the Company takes with respect to any or all income tax, social
security, payroll tax, or other tax-related withholding (“Tax-Related Items”), the ultimate liability for all
Tax-Related Items is and remains the Participant’s responsibility and the Company (a) makes no representation or undertakings regarding
the treatment of any Tax-Related Items in connection with the grant, vesting, or settlement of the RSUs or the subsequent sale of any
Shares acquired upon settlement of the RSUs; and (b) does not commit to structure the RSUs to reduce or eliminate the Participant’s
liability for Tax-Related Items.

 

10.           Notices. Any notice required to be given or delivered to the Plan Administrator or the Company under the terms of this
Agreement shall be in writing (including a writing delivered by facsimile transmission or electronic mail) and addressed to the Plan Administrator
at the principal corporate office of the Company. Any notice required to be given or delivered to Participant shall be in writing (including
a writing delivered by facsimile transmission or electronic mail) and addressed to Participant at the address indicated above or to such
other address as such party may designate in writing from time to time to the Plan Administrator. All notices shall be deemed to have
been given or delivered upon: (a) personal delivery; (b) five (5) days after deposit in the United States mail by certified or registered
mail (return receipt requested); (c) one (1) business day after deposit with any return receipt express courier (prepaid); or (d) when
receipt is acknowledged after transmission by facsimile or electronic mail.

 

11.           Interpretation. Any dispute regarding the interpretation of this Agreement shall be submitted by Participant or the
Company to the Plan Administrator for review. The resolution of such a dispute by the Plan Administrator shall be final and binding on
the Company and Participant.

 

12.           Successors and Assigns. The Company may assign any of its rights or obligations under this Agreement. This Agreement
shall be binding upon and inure to the benefit of the successors and assigns of the Company. Subject to the restrictions on transfer set
forth herein, this Agreement shall be binding upon Participant and Participant’s heirs, executors, administrators, and legal representatives.

 

13.           Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware
without giving effect to its conflict of law principles. If any provision of this Agreement is determined by a court of law to be illegal
or unenforceable, then such provision will be enforced to the maximum extent possible and the other provisions will remain fully effective
and enforceable.

 

    3

     

    

 

14.          Choice of Forum. Participant hereby irrevocably and unconditionally submits, for itself and its property, to the exclusive
jurisdiction of the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts
of the United States of America sitting in the state of Delaware), and any appellate court from any thereof, in any action or proceeding
arising out of or relating to this Award Agreement, the Shares issued in connection herewith or for recognition or enforcement of any
judgment relating thereto, and Participant hereby (i) agrees not commence any such action or proceeding except in the state courts of
Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts of the United States of America
sitting in the state of Delaware), (ii) agrees that any claim in respect of any such action or proceeding may be heard and determined
in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts of the United
States of America sitting in the state of Delaware), and any appellate court from any thereof, (iii) waives, to the fullest extent it
may legally and effectively do so, any objection which it may now or hereafter have to the laying of venue of any such action or proceeding
in the state courts of Delaware (and if jurisdiction in the state courts of Delaware shall be unavailable, the Federal courts of the United
States of America sitting in the state of Delaware), and (iv) waives, to the fullest extent it may legally and effectively do so, the
defense of an inconvenient forum to the maintenance of such action or proceeding in the state courts of Delaware (and if jurisdiction
in the state courts of Delaware shall be unavailable, the Federal courts of the United States of America sitting in the state of Delaware).

 

15.          Waiver of Jury Trial. EACH OF THE PARTIES HERETO IRREVOCABLY AND UNCONDITIONALLY WAIVES THE RIGHT TO A TRIAL BY JURY
IN ANY ACTION, SUIT OR PROCEEDING RELATING TO A DISPUTE ARISING OUT OF OR RELATING TO THIS AWARD AGREEMENT AND FOR ANY COUNTERCLAIM WITH
RESPECT THERETO.

 

16.          Counterparts. This Award Agreement may be executed in counterparts, each of which shall be deemed an original but all
of which together will constitute one and the same instrument. Counterpart signature pages to this Agreement transmitted by facsimile
transmission, by electronic mail in portable document format (.pdf), or by any other electronic means intended to preserve the original
graphic and pictorial appearance of a document, will have the same effect as physical delivery of the paper document bearing an original
signature.

 

17.          Severability. If any provision of this Award Agreement is determined by a court of law to be illegal or unenforceable,
then such provision will be enforced to the maximum extent possible and the other provisions will remain fully effective and enforceable.

 

18.          Further Instruments. The parties agree to execute such further instruments and to take such further action as may be
reasonably necessary to carry out the purposes and intent of this Award Agreement.

 

19.          Headings. The captions and headings of this Award Agreement are included for ease of reference only and will be disregarded
in interpreting or construing this Award Agreement.

 

20.          Gender and Number. In construing this Award Agreement, any masculine terminology herein shall also include the feminine,
and the definition of any term herein in the singular shall also include the plural, except when otherwise indicated by the context.

 

    4

     

    

 

21.          Entire Agreement. The Plan is incorporated herein by reference. This Award Agreement and the Plan constitute the entire
agreement of the parties and supersede all prior undertakings and agreements with respect to the subject matter hereof. If any inconsistency
should exist between the nondiscretionary terms and conditions of this Award Agreement and the Plan, the Plan shall govern and control.

 

22.          Acceptance. Participant hereby acknowledges that he has read and understands the terms and provisions of this Agreement,
and accepts the Award subject to all the terms and conditions of the Plan and this Agreement. Participant has had an opportunity to obtain
the advice of legal counsel prior to executing this Agreement. Participant acknowledges that there may be adverse tax consequences upon
exercise of this Award and disposition of the Shares, and that Participant should consult a tax advisor prior to such exercise or disposition.
Participant attests that he is relying solely on such advisors and not on any statements or representations of the Plan Administrator,
the Company, or any Affiliate, or any agents thereof. Further, Participant hereby acknowledges and understands that he (and not the
Company) shall be solely responsible for his tax liability that may arise as a result of receiving this Award Agreement.

 

 

[Remainder of page intentionally left blank.]

 

    5

     

    

 

IN WITNESS WHEREOF, the Company
has caused this Agreement to be executed duplicate by its duly authorized representative and Participant has executed this Agreement in
duplicate, effective as of the Award Date.

 

	 	BIO-PATH HOLDINGS, INC.
	 	 
	 	 
	 	By:	                     
	 	 	 
	 	 
	 	PARTICIPANT 
	 	 
	 	 
	 	 
	 	(Signature)
	 	 
	 	(Please print name)
	 	 
	 	Address:
	 	 
	 	 

	 	Facsimile:	 
	 	E-mail:	 

 

    6

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