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Exhibit 10.18    
    

[OPTIMER
LOGO] 

August 30,
2001 

Dr.
Tessie M. Che

[address] 

Dear
Dr. Che: 

It
is with great pleasure for me to invite you to join Optimer Pharmaceutical, Inc. team in the capacity of Vice President of Corporate Affairs, reporting to the CEO. You will be responsible for all
the activities in Corporate Affairs. 

Associated
with this opportunity, we offer the following compensation: 

	1.
	Annual
base salary: $180,000 US Dollars.

	2.
	Optimer
offers a competitive benefit package that includes medical and dental coverage for you and your family, 401(k) plan, and Group Term Life Insurance for you.

	3.
	Stock
Options: You are offered initially 180,000 shares of Stock Options, vest equally over a four-year period with one-year cliff and vesting monthly thereafter. The share option
price shall be 30 cents per share and you can exercise your options within 10 years after vesting.

	4.
	Four
weeks of paid vacation annually. 

If
you agree to the offer as stated above, please sign and return a copy of this letter to Jodi Ross in Human Resources. 

Sincerely, 

[SIGNATURE
TO COME]

Michael N. Chang

CEO

Optimer Pharmaceuticals, Inc. 

	
 I accept the offer as stipulated above:	

/s/ Dr. Tessie M. Che
 Dr. Tessie M. Che	
 	

9-06-01
 Date

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Exhibit 10.19    
    

Optimer Pharmaceuticals, Inc.  

151 Cliff Swall Court, Brisbane, CA 94010

Tel. 415-468-5859

Fax. 415-468-5005  

February 18, 2000 

Dr.
Youe-Kong Shue

[address] 

Dear
Youe-Kong: 

It
is with great pleasure that I offer you the position of Senior Director of Chemistry with Optimer Pharmaceuticals, Inc. This position is located in San Diego, California. 

Associated
with this opportunity, we offer the following compensation: 

	1.
	Annual
base salary: $150,000 US Dollars

	2.
	Optimer
offers a competitive benefit package to you and your family that includes medical, dental, and Group Term Life Insurance.

	3.
	Stock
Options: You are offered Optimer, Inc. Stock Options equal to 1% of the total number of shares outstanding which are calculated based on the first day of your employment,
projected to be May 1, 2000. This date is subject to change, depending on mutual agreement but no later than 3 months after closing of the first round financing. Stock options are vested
equally over a four year period, with a one-year cliff; options will be vested monthly thereafter. The share option price shall be 10 cents per share and you can exercise your options within
10 years after vesting. In addition, we offer you an additional 0.6% of the total number of stock options at the time of Issuance of Preferred B Series based on your reaching certain
milestones which will be discussed with your shortly. The option price shall be 10% of the Preferred B share price.

	4.
	Optimer
will assist you in relocating your family to San Diego. This package includes covering the cost of selling of your current residence, temporary housing, commuting between
Boston and San Diego before the actual move of the family, expenses related to the purchase of a new home in San Diego, the moving of your family and household goods to San Diego. The total amount,
including tax gross up, is capped at $100,000 US dollars. The company will collaborate with you on seeking ways to minimize your tax impact of the relocation.

	5.
	Optimer
will pay you a special one-time bonus of $45,000, payable at the time of successful completion of Preferred B Series shares offering.

	6.
	Optimer
will set up a 401k plan for its employees within 6 months after beginning operations. 

In
the event you leave the company within two years after relocating, you agree to repay Optimer those expenses and bonus described in Items 4 and 5 above. 

If
you agree to this offer as stated above, please sign below and return a copy of this letter to us at your earliest convenience. 

 

If
you have any questions, please call me. 

	
 	
 	

Sincerely,
	
 	
 	

/s/  MICHAEL N. CHANG      
 Michael N. Chang, Ph.D.

CEO, Optimer Pharmaceutical, Inc.

	
 I accept the offer as stipulated above:	
 	

/s/  YOUE-KONG SHUE      
 Dr. Youe-Kong Shue	
 	

02/20/2000
 Date	
 	

 

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Exhibit 10.20    
    

OPTIMER PHARMACEUTICALS, INC.  

 INDEMNIFICATION AGREEMENT  

        This Indemnification Agreement ("Agreement") is made as of this      day of
                        , 2002, by and between Optimer Pharmaceuticals, Inc., a Delaware corporation
(the "Company"),
and                          ("Indemnitee"). 

        WHEREAS, the Company and Indemnitee recognize the significant cost of directors' and officers' liability insurance and the general
reductions in the coverage of such insurance; 

        WHEREAS, the Company and Indemnitee further recognize the substantial increase in corporate litigation in general, subjecting officers and
directors to expensive litigation risks at the same time as the coverage of liability insurance has been severely limited; and 

        WHEREAS, the Company desires to attract and retain the services of highly qualified individuals, such as Indemnitee, to serve as officers
and directors of the Company and to indemnify its officers and directors so as to provide them with the maximum protection permitted by law. 

        NOW, THEREFORE, in consideration for Indemnitee's services as an officer or director of the Company, the Company and Indemnitee hereby
agree as follows: 

        1.    Indemnification.    

        (a)   Third Party Proceedings.    The Company shall indemnify Indemnitee if Indemnitee is or was a party or is
threatened to be made a party to any threatened, pending or completed action, suit, proceeding or any alternative dispute resolution mechanism, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the Company) by reason of the fact that Indemnitee is or was a director, officer, employee or agent of the Company, or any subsidiary of the Company, or by
reason of the fact that Indemnitee is or was serving at the request of the Company as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other
enterprise, against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement (if such settlement is approved in advance by the Company, which approval shall not be
unreasonably withheld) actually and reasonably incurred by Indemnitee in connection with such action, suit or proceeding if Indemnitee acted in good faith and in a manner Indemnitee reasonably
believed to be in or not opposed to the best interests of the Company, and, with respect to any criminal action or proceeding, had no reasonable cause to believe Indemnitee's conduct was unlawful. The
termination of any action, suit or proceeding by judgment, order, settlement, conviction, or upon a plea of nolo contendere or its equivalent, shall
not, of itself, create a presumption that Indemnitee did not act in good faith and in a manner which Indemnitee reasonably believed to be in or not opposed to the best interests of the Company, and,
with respect to any criminal action or proceeding, had reasonable cause to believe that Indemnitee's conduct was unlawful. 

 

        (b)   Proceedings By or in the Right of the Company.    The Company shall indemnify Indemnitee if Indemnitee was or
is a party or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the Company or any subsidiary of the Company to procure a judgment in its
favor by reason of the fact that Indemnitee is or was a director, officer, employee or agent of the Company, or any subsidiary of the Company, or by reason of the fact that Indemnitee is or was
serving at the request of the Company as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys'
fees) and, to the fullest extent permitted by law, amounts paid in settlement actually and reasonably incurred by Indemnitee in connection with the defense or settlement of such action or suit if
Indemnitee acted in good faith and in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the Company, except that no indemnification shall be made in respect of
any claim, issue or matter as to which Indemnitee shall have been adjudged to be liable to the Company unless and only to the extent that the Court of Chancery of the State of Delaware or the court in
which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, Indemnitee is fairly and reasonably
entitled to indemnity for such expenses which the Court of Chancery of the State of Delaware or such other court shall deem proper. 

        (c)   Mandatory Payment of Expenses.    To the extent that Indemnitee has been successful on the merits or otherwise
in defense of any action, suit or proceeding referred to in Subsections (a) and (b) of this Section 1, or in defense of any claim, issue or matter therein,
Indemnitee shall be indemnified against expenses (including attorneys' fees) actually and reasonably incurred by Indemnitee in connection therewith. 

        2.    Agreement to Serve.    In consideration of the protection afforded by this Agreement, if
Indemnitee is a director of the Company he agrees to serve at least for the 90 days after the effective date of this Agreement as a director and not to resign voluntarily during such period
without the written consent of a majority of the Board of Directors. If Indemnitee is an officer of the Company not serving under an employment contract, he agrees to serve in such capacity at least
for 90 days and not to resign voluntarily during such period without the written consent of a majority of the Board of Directors. Following the applicable period set forth above, Indemnitee
agrees to continue to serve in such capacity at the will of the Company (or under separate agreement, if such agreement exists) so long as he is duly appointed or elected and qualified in
accordance with the applicable provisions of the Bylaws of the Company or any subsidiary of the Company or until such time as he tenders his resignation in writing. Nothing contained in this Agreement
is intended to create in Indemnitee any right to continued employment. 

        3.    Expenses; Indemnification Procedure.    

        (a)   Advancement of Expenses.    The Company shall advance all expenses incurred by Indemnitee in connection with
the investigation, defense, settlement or appeal of any civil or criminal action, suit or proceeding referenced in Section 1(a) or (b) hereof (but not amounts
actually paid in settlement of any such action, suit or proceeding). Indemnitee hereby undertakes to repay such amounts advanced only if, and to the extent that, it shall ultimately be determined that
Indemnitee is not entitled to be indemnified by the Company as authorized hereby. The advances to be made hereunder shall be paid by the Company to Indemnitee within thirty (30) days following
delivery of a written request therefor by Indemnitee to the Company. 

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        (b)   Notice/Cooperation by Indemnitee.    Indemnitee shall, as a condition precedent to his right to be indemnified
under this Agreement, give the Company notice in writing as soon as practicable of any claim made against Indemnitee for which indemnification will or could be sought under this Agreement. Notice to
the Company shall be directed to the President of the Company at the address shown on the signature page of this Agreement (or such other address as the Company shall designate in writing to
Indemnitee). Notice shall be deemed received three business days after the date postmarked if sent by domestic certified or registered mail, properly addressed, five business days if sent by airmail
to a country outside of North America; otherwise notice shall be deemed received when such notice shall actually be received by the Company. In addition, Indemnitee shall give the Company such
information and cooperation as it may reasonably require and as shall be within Indemnitee's power. 

        (c)   Procedure.    Any indemnification and advances provided for in Section 1 and this
Section 3 shall be made no later than thirty (30) days after receipt of the written request of Indemnitee. If a claim under this Agreement, under any statute, or under any provision of
the Company's Certificate of Incorporation or Bylaws providing for indemnification, is not paid in full by the Company within thirty (30) days after a written request for payment thereof has
first been received by the Company, Indemnitee may, but need not, at any time thereafter bring an action against the Company to recover the unpaid amount of the claim and, subject to Section 14
of this Agreement, Indemnitee shall also be entitled to be paid for the expenses (including attorneys' fees) of bringing such action. It shall be a defense to any such action (other than an action
brought to enforce a claim for expenses incurred in connection with any action, suit or proceeding in advance of its final disposition) that Indemnitee has not met the standards of conduct which make
it permissible under applicable law for the Company to indemnify Indemnitee for the amount claimed. However, Indemnitee shall be entitled to receive interim payments of expenses pursuant to
Subsection 3(a) unless and until such defense may be finally adjudicated by court order or judgment from which no further right of appeal exists. It is the parties' intention that if the
Company contests Indemnitee's right to indemnification, the question of Indemnitee's right to indemnification shall be for the court to decide, and neither the failure of the Company (including its
Board of Directors, any committee or subgroup of the Board of Directors, independent legal counsel, or its stockholders) to have made a determination that indemnification of Indemnitee is proper in
the circumstances because Indemnitee has met the applicable standard of conduct required by applicable law, nor an actual determination by the Company (including it Board of Directors, any committee
or subgroup of the Board of Directors, independent legal counsel, or its stockholders) that Indemnitee has not met such applicable standard of conduct, shall create a presumption that Indemnitee has
or has not met the applicable standard of conduct. 

        (d)   Notice to Insurers.    If, at the time of the receipt of a notice of a claim pursuant to
Section 3(b) hereof, the Company has director and officer liability insurance in effect, the Company shall give prompt notice of the commencement of such proceeding to the insurers in
accordance with the procedures set forth in the respective policies. The Company shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee, all
amounts payable as a result of such proceeding in accordance with the terms of such policies. 

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        (e)   Selection of Counsel.    In the event the Company shall be obligated under Section 3(a) hereof to
pay the expenses of any proceeding against Indemnitee, the Company, if appropriate, shall be entitled to assume the defense of such proceeding, with counsel approved by Indemnitee, upon the delivery
to Indemnitee of written notice of its election to do so. After delivery of such notice, approval of such counsel by Indemnitee and the retention of such counsel by the Company, the Company will not
be liable to Indemnitee under this Agreement for any fees of counsel subsequently incurred by Indemnitee with respect to the same proceeding, provided that (i) Indemnitee shall have the right
to employ his counsel in any such proceeding at Indemnitee's expense; and (ii) if (A) the employment of counsel by Indemnitee has been previously authorized by the Company,
(B) Indemnitee shall have reasonably concluded that there may be a conflict of interest between the Company and Indemnitee in the conduct of any such defense, or (C) the Company shall
not, in fact, have employed counsel to assume the defense of such proceeding, then the fees and expenses of Indemnitee's counsel shall be at the expense of the Company. 

        4.    Additional Indemnification Rights; Nonexclusivity.    

        (a)   Scope.    Notwithstanding any other provision of this Agreement, the Company hereby agrees to indemnify the
Indemnitee to the fullest extent permitted by law, notwithstanding that such indemnification is not specifically authorized by the other provisions of this Agreement, the Company's Certificate of
Incorporation, the Company's Bylaws or by statute. In the event of any change, after the date of this Agreement, in any applicable law, statute, or rule which expands the right of a Delaware
corporation to indemnify a member of its board of directors or an officer, such changes shall be, ipso facto, within the purview of Indemnitee's rights
and Company's obligations, under this Agreement. In the event of any change in any applicable law, statute or rule which narrows the right of a Delaware corporation to indemnify a member of its board
of directors or an officer, such changes, to the extent not otherwise required by such law, statute or rule to be applied to this Agreement shall have no effect on this Agreement or the parties'
rights and obligations hereunder. 

        (b)   Nonexclusivity.    The indemnification provided by this Agreement shall not be deemed exclusive of any rights
to which Indemnitee may be entitled under the Company's Certificate of Incorporation, its Bylaws, any agreement, any vote of stockholders or disinterested Directors, the General Corporation Law of the
State of Delaware, or otherwise, both as to action in Indemnitee's official capacity and as to action in another capacity while holding such office. The indemnification provided under this Agreement
shall continue as to Indemnitee for any action taken or not taken while serving in an indemnified capacity even though he may have ceased to serve in such capacity at the time of any action, suit or
other covered proceeding. 

        5.    Partial Indemnification.    If Indemnitee is entitled under any provision of this
Agreement to indemnification by the Company for some or a portion of the expenses, judgments, fines or penalties actually or reasonably incurred by him in the investigation, defense, appeal or
settlement of any civil or criminal action, suit or proceeding, but not, however, for the total amount thereof, the Company shall nevertheless indemnify Indemnitee for the portion of such expenses,
judgments, fines or penalties to which Indemnitee is entitled. 

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        6.    Mutual Acknowledgement.    Both the Company and Indemnitee acknowledge that in certain
instances, Federal law or applicable public policy may prohibit the Company from indemnifying its directors and officers under this Agreement or otherwise. Indemnitee understands and acknowledges that
the Company has undertaken or may be required in the future to undertake with the Securities and Exchange Commission to submit the question of indemnification to a court in certain circumstances for a
determination of the Company's right under public policy to indemnify Indemnitee. 

        7.    Officer and Director Liability Insurance.    The Company shall, from time to time, make
the good faith determination whether or not it is practicable for the Company to obtain and maintain a policy or policies of insurance with reputable insurance companies providing the officers and
directors of the Company with coverage for losses from wrongful acts, or to ensure the Company's performance of its indemnification obligations under this Agreement. Among other considerations, the
Company will weigh the costs of obtaining such insurance coverage against the protection afforded by such coverage. In all policies of director and officer liability insurance, Indemnitee shall be
named as an insured in such a manner as to provide Indemnitee the same rights and benefits as are accorded to the most favorably insured of the Company's directors, if Indemnitee is a director; or of
the Company's officers, if Indemnitee is not a director of the Company but is an officer. Notwithstanding the foregoing, the Company shall have no obligation to obtain or maintain such insurance if
the Company determines in good faith that such insurance is not reasonably available, if the premium costs for such insurance are disproportionate to the amount of coverage provided, if the coverage
provided by such insurance is limited by exclusions so as to provide an insufficient benefit, or if Indemnitee is covered by similar insurance maintained by a subsidiary or parent of the Company. 

        8.    Severability.    Nothing in this Agreement is intended to require or shall be construed
as requiring the Company to do or fail to do any act in violation of applicable law. The Company's inability, pursuant to court order, to perform its obligations under this Agreement shall not
constitute a breach of this Agreement. The provisions of this Agreement shall be severable as provided in this Section 8. If this Agreement or any portion hereof shall be invalidated on any
ground by any court of competent jurisdiction, then the Company shall nevertheless indemnify Indemnitee to the full extent permitted by any applicable portion of this Agreement that shall not have
been invalidated, and the balance of this Agreement not so invalidated shall be enforceable in accordance with its terms. 

        9.    Exceptions.    Any other provision herein to the contrary notwithstanding, the Company
shall not be obligated pursuant to the terms of this Agreement: 

        (a)   Claims Initiated by Indemnitee.    To indemnify or advance expenses to Indemnitee with respect to proceedings
or claims initiated or brought voluntarily by Indemnitee and not by way of defense, except with respect to proceedings brought to establish or enforce a right to indemnification under this Agreement
or any other statute or law or otherwise as required under Section 145 of the Delaware General Corporation Law, but such indemnification or advancement of expenses may be provided by the
Company in specific cases if the Board of Directors has approved the initiation or bringing of such suit; or 

5

 

        (b)   Lack of Good Faith.    To indemnify Indemnitee for any expenses incurred by the Indemnitee with respect to any
proceeding instituted by Indemnitee to enforce or interpret this Agreement, if a court of competent jurisdiction determines that each of the material assertions made by the Indemnitee in such
proceeding was not made in good faith or was frivolous; or 

        (c)   Insured Claims.    To indemnify Indemnitee for expenses or liabilities of any type whatsoever (including, but
not limited to, judgments, fines, ERISA excise taxes or penalties, and amounts paid in settlement) which have been paid directly to Indemnitee by an insurance carrier under a policy of officers' and
directors' liability insurance maintained by the Company. 

        (d)   Claims Under Section 16(b).    To indemnify Indemnitee for expenses and the payment of profits arising
from the purchase and sale by Indemnitee of securities in violation of Section 16(b) of the Securities Exchange Act of 1934, as amended, or any similar successor statute. 

        10.    Construction of Certain Phrases.    

        (a)   For
purposes of this Agreement, references to the "Company" shall include, in addition to the resulting corporation, any constituent corporation (including any
constituent of a constituent) absorbed in a consolidation or merger which, if its separate existence had continued, would have had power and authority to indemnify its directors, officers, and
employees or agents, so that if Indemnitee is or was a director, officer, employee or agent of such constituent corporation, or is or was serving at the request of such constituent corporation as a
director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, Indemnitee shall stand in the same position under the provisions of this Agreement
with respect to the resulting or surviving corporation as Indemnitee would have with respect to such constituent corporation if its separate existence had continued. 

        (b)   For
purposes of this Agreement, references to "other enterprises" shall include employee benefit plans; references to "fines" shall include any excise taxes assessed on
Indemnitee with respect to an employee benefit plan; and references to "serving at the request of the Company" shall include any service as a director, officer, employee or agent of the Company which
imposes duties on, or involves services by, such director, officer, employee or agent with respect to an employee benefit plan, its participants, or beneficiaries; and if Indemnitee acted in good
faith and in a manner Indemnitee reasonably believed to be in the interest of the participants and beneficiaries of an employee benefit plan, Indemnitee shall be deemed to have acted in a manner "not
opposed to the best interests of the Company" as referred to in this Agreement. 

        11.    Counterparts.    This Agreement may be executed in one or more counterparts, each of
which shall constitute an original. 

        12.    Successors and Assigns.    This Agreement shall be binding upon the Company and its
successors and assigns, and shall inure to the benefit of Indemnitee and Indemnitee's estate, heirs, legal representatives and assigns. 

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        13.    Attorneys' Fees.    In the event that any action is instituted by Indemnitee under this
Agreement to enforce or interpret any of the terms hereof, Indemnitee shall be entitled to be paid all court costs and expenses, including reasonable attorneys' fees, incurred by Indemnitee with
respect to such action, unless as a part of such action, the court of competent jurisdiction determines that each of the material assertions made by Indemnitee as a basis for such action were not made
in good faith or were frivolous. In the event of an action instituted by or in the name of the Company under this Agreement or to enforce or interpret any of the terms of this Agreement, Indemnitee
shall be entitled to be paid all court costs and expenses, including attorneys' fees, incurred by Indemnitee in defense of such action (including with respect to Indemnitee's counterclaims and
cross-claims made in such action), unless as a part of such action the court determines that each of Indemnitee's material defenses to such action were made in bad faith or were frivolous. 

        14.    Notice.    All notices, requests, demands and other communications under this Agreement
shall be in writing and shall be deemed duly given (i) if delivered by hand and receipted for by the party addressee, on the date of such receipt, or (ii) if mailed by domestic certified
or registered mail with postage prepaid, on the third business day after the date postmarked. Addresses for notice to either party are as shown on the signature page of this Agreement, or as
subsequently modified by written notice. 

        15.    Consent to Jurisdiction.    The Company and Indemnitee each hereby irrevocably consent
to the jurisdiction of the courts of the State of Delaware for all purposes in connection with any action or
proceeding which arises out of or relates to this Agreement and agree that any action instituted under this Agreement shall be brought only in the state courts of the State of Delaware. 

        16.    Choice of Law.    This Agreement shall be governed by and its provisions construed in
accordance with the laws of the State of Delaware, as applied to contracts between Delaware residents entered into and to be performed entirely within Delaware without regard to the conflict of law
principles thereof. 

        17.    Period of Limitations.    No legal action shall be brought and no cause of action shall
be asserted by or in the right of the Company against Indemnitee, Indemnitee's estate, spouse, heirs, executors or personal or legal representatives after the expiration of two years from the date of
accrual of such cause of action, and any claim or cause of action of the Company shall be extinguished and deemed released unless asserted by the timely filing of a legal action within such
two-year period; provided, however, that if any shorter period of limitations is otherwise applicable to any such cause of action, such
shorter period shall govern. 

        18.    Subrogation.    In the event of payment under this Agreement, the Company shall be
subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all documents required and shall do all acts that may be necessary to secure such rights and
to enable the Company effectively to bring suit to enforce such rights. 

        19.    Amendment and Termination.    No amendment, modification, termination or cancellation
of this Agreement shall be effective unless it is in writing signed by both the parties hereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any
other provisions hereof (whether or not similar) nor shall such waiver constitute a continuing waiver. 

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        20.    Integration and Entire Agreement.    This Agreement sets forth the entire understanding
between the parties hereto and supersedes and merges all previous written and oral negotiations, commitments, understandings and agreements relating to the subject matter hereof between the parties
hereto. 

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        IN
WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. 

	
 	
 	

 	
 	
OPTIMER PHARMACEUTICALS, INC.
	
    	
 	

 	
 	

 	
 	

 
	
 	
 	

 	
 	

Signature of Authorized Signatory
	
 	
 	

 	
 	

Print Name and Title
	
    	
 	

 	
 	

 	
 	

 
	
 	
 	

 	
 	

Address:	
 	

	
    	
 	

 	
 	

 	
 	

	
    	
 	

 	
 	

 	
 	

 
	AGREED TO AND ACCEPTED:	 	 	 	 
	
INDEMNITEE:	
 	

 	
 	

 
	

Signature	
 	

 	
 	

 
	

Print Name and Title	
 	

 	
 	

 
	
 Address:	
 	

    
    
	
 	

 	
 	

 

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Exhibit 10.20

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