Document:

EXHIBIT 4.14

EMPLOYMENT AGREEMENT

          THIS EMPLOYMENT AGREEMENT (“Agreement”) is made and entered into as of July 26, 2005 (the “Effective Date”) by and between IsoTis SA (the “Company” or “IsoTis”) and Kathe Liljestrand (“Employee”).

          WHEREAS, Employee is currently employed by the Company and has been employed by the Company and its affiliates since August 1, 2005 (“Start Date”);

          WHEREAS, the Company and Employee (the “Parties”) wish to ensure the Company’s access to Employee’s continued services, and the terms on which those services will be provided;

          THEREFORE, the Parties agree as follows:

1.       EMPLOYMENT

          The Company hereby employs Employee and Employee hereby accepts employment upon the terms and conditions set forth below.

2.       TERM

          2.1     Term.  The term of this Agreement shall commence on August 1, 2005 the (“Effective Date”), and shall continue on the terms and conditions set forth below, until Employee’s employment is terminated as provided in Section 5 (the “Term”).

3.       COMPENSATION

          3.1     Base Compensation.  Employee shall be paid a salary at the annual rate of $175,000 (the “Base Compensation”).  The Base Compensation shall be reviewed at least annually, and may be increased, but not decreased.  In the event that the Base Compensation is increased, the new salary shall be the Base Compensation for purposes of this Agreement thereafter.

          3.2     Bonus Compensation.  The Compensation Committee of the Board of Directors of the Company (the “Compensation Committee”), or its designee, shall review Employee’s performance on an annual basis.  The Board of Directors shall cause the Company to award Employee (a) for 2005, a bonus in an amount up to 30% of Employee’s Base Compensation, which the Board of Directors or its designee determines in its sole and absolute discretion, based upon the recommendation of the Compensation Committee or its designee, and (b) for 2006 and subsequent years, such amount which the Board of Directors determines in its sole and absolute discretion based upon the recommendation of the Compensation Committee or its designee. 

          3.3     Benefits.  The Employee shall be entitled to participate in all pension, 401(k) and other employee plans and benefits in accordance with the terms of such plans or policies as may be in effect from time to time.  The Company shall provide Employee with health care benefits and life insurance, at the Company’s expense, as in effect on the Effective Date.

          3.4     Automobile Allowance.  The Company shall provide Employee with an automobile allowance of five hundred ($500) dollars per month during the term of Employee’s employment hereunder.

          3.5     Housing Allowance.  The Company shall provide Employee with a housing allowance of two thousand ($2,000) dollars per month for the first 12 months following the Start Date.   

          3.6     Method of Payment.  The monetary compensation payable and any benefits due to Employee hereunder may be paid or provided in whole or in part, from time to time, by the Company and/or its respective parents, subsidiaries and affiliates, but shall at all times remain the responsibility of the Company.

4.       POSITION AND DUTIES

          4.1     Position or Duties.  Employee shall hold such position and have such duties as assigned to him/her by the Company from time to time.

          4.2     Devotion of Time and Effort.  Employee shall use Employee’s good faith best efforts and judgment in performing Employee’s duties as required hereunder and to act in the best interests of the Company.  Employee shall devote all of his business time, attention and energies to the business of the Company.

          4.3     Other Activities.  Employee may engage in other activities for Employee’s own account while employed hereunder, including without limitation, charitable, community and other business activities, provided that in the judgment of the Board of Directors of the Company (the “Board”) such other activities do not materially interfere with the performance of Employee’s duties hereunder, and do not violate Sections 6 and 7.  With regard to any other businesses or activities, Employee shall notify the Board to address all such activities and shall not begin such activities until Employee receives written approval from the Board.  This restriction shall not apply to Employee’s passive investment in less than one (1)  percent of the publicly traded securities of a publicly traded entity. 

          4.4     Vacation.  Employee shall be subject to the Company’s policies concerning accrual, use and scheduling of vacation, as such policies may be in effect from time to time. 

          4.5     Business Expenses.  Employee shall be entitled to reimbursement of reasonable business expenses in accordance with Company policies, as they may be in effect from time to time.

5.       TERMINATION

          5.1     Due to Death.  Employee’s employment shall terminate as of the date of his/her death. 

          5.2     Due to Disability.  The Company may terminate Employee’s employment if he/she becomes “disabled”, as defined below, upon written notice to Employee.  For purposes of this Agreement, the term “Disability” shall mean a physical or mental incapacity as a result of which Employee becomes unable to continue to perform the essential functions of the job with or without accommodation hereunder for six consecutive calendar months or for shorter periods aggregating 180 business days in any 12 month period, or, if this provision is inconsistent with any applicable law, to the extent not prohibited by law.

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          5.3     By the Company Without “Cause”. The Company may terminate Employee’s employment without “Cause” as defined in Section 5.5 below at any time following the Effective Date, upon 30 days written notice to Employee. 

          5.4     By Employee Without “Good Reason”.  Employee may terminate his/her employment hereunder without Good Reason, as defined in Section 5.6 below, at any time upon 30 days written notice (the “Notice Period”) to the Company.  During the Notice Period, Employee shall continue to perform Employee’s duties hereunder and shall not accept any other employment. 

          5.5     By The Company For Cause.  The Company may terminate Employee’s employment for “Cause” at any time, upon written notice to Employee.  For purposes of this Agreement, “Cause” shall mean:

                    (a)     Employee’s conviction of or plea of nolo contender to a felony or any crime involving moral turpitude; 

                    (b)     Employee’s commission of any act of theft, embezzlement or misappropriation against the Company;

                    (c)     Employee’s failure to substantially perform Employee’s duties hereunder (other than such failure resulting from Employee’s incapacity due to physical or mental illness), which failure is not remedied within thirty (30) days after written demand for substantial performance is delivered by the Company which specifically identifies the manner in which the Company believes that Employee has not substantially performed Employee’s duties; or

                    (d)     Employee’s material breach of his obligations under this Agreement, which breach is not remedied within thirty (30) days after written notice is delivered by the Company which specifically identifies the breach that the Company believes has occurred.

          5.6     By Employee For Good Reason.  Employee may terminate his employment for good reason upon at least thirty (30) days prior written notice to the Company.  For purposes of this Agreement, “Good Reason” shall mean the Company’s material breach of the salary and benefit obligations hereunder and either such breach is incurable or, if curable, has not been cured within fifteen (15) days following receipt of written notice by Employee to the Company of such breach by the Company.  Employee shall be deemed to have waived Employee’s right to terminate for “good reason” with respect to a breach if Employee does not notify the Company in writing of such breach within fifteen (15) days of such breach, or, if such breach is not immediately known to him, and could not reasonably be expected to be know by him, within
fifteen (15) days of his discovery of such breach.  Following a Change in Control, as defined below, “Good Reason” shall also mean: (a) a material reduction in the authority of Employee; (b) a change in Employee’s title; or (c) a relocation of Employee’s primary office to a location more than 80 miles from Irvine, California, without Employee’s prior written consent.

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The fact that the Company becomes a subsidiary of another entity, or that the Company’s status changes from publicly-traded to privately-held, as a result of the Change in Control, shall not, by itself, constitute a material reduction in the authority of Employee, an adverse change in Employee’s title, or Employee’s primary reporting relationship being changed such that Employee no longer reports to a person or person of the same level of authority in the Company.  In addition, provided that Employee remains employed by the Company for one (1) year following a Change in Control, during the thirty (30) days following the first anniversary of the Change in Control, if Employee elects to terminate his employment with the Company for any reason or no reason, he shall be deemed to have “Good Reason”.

          5.7     Severance Payment.  In the event Employee’s employment terminates pursuant to Sections 5.1 (Death), 5.4 (Without Good Reason), or 5.5 (For Cause), Employee (or Employee’s estate, as applicable) shall have the right to receive Employee’s compensation as otherwise provided under this Agreement through the effective date of termination.  Employee shall have no further right to receive compensation, benefits or other consideration from the Company, and Employee shall not be entitled to any severance payments or benefits, except as required by applicable law.  In the event that Employee’s employment is terminated pursuant to Section 5.2 (Due to Disability), Section 5.3 (Without Cause), or Section 5.6 (For Good Reason), Employee shall continue to render services to the Company pursuant to this Agreement until the date of
termination and shall continue to receive compensation, as provided in this Agreement, through the termination date.  Thereafter, Employee shall be entitled to severance pay and benefits as set forth in subparagraph (a) through (c) below, and subject to subparagraph (d) below, provided that Employee executes and delivers (and does not revoke, if a revocation period is required by law) a general release of claims in a form acceptable to the Company in its sole and absolute discretion, and is not in material breach of any of the provisions of this Agreement.

                    (a)     Amount.  In addition to other compensation payable to Employee for services rendered through the termination date, the Company shall pay executive no later than the date of such termination date, as a single severance payment, an amount equal to the sum of (i) 12 times Employee’s highest monthly Base Compensation paid hereunder during the preceding twenty-four month period plus (ii) 0.5 times the average annual bonus (excluding any bonus payment deemed by the Compensation Committee in its sole discretion to be “Special Bonus”) received by the Employee during the preceding twenty-four month period (collectively, the “Severance Amount”).  Notwithstanding the forgoing, payment of all or a portion of the Severance Amount shall be delayed to the extent necessary to
comply with Section 409A of the Internal Revenue Code (the “Code”).

                    (b)     Vesting of Equity Awards.  In addition to the Severance Payments, in the event that Employee’s employment is terminated pursuant to Section 5.1 (Death), Section 5.2 (Due to Disability), Section 5.3 (Without Cause), or Section 5.6 (For Good Reason), such portion of the unvested options or restricted stock of the Company held by the Employee as set forth below shall immediately vest and be exercisable and will continue to be exercisable for three months, after which time they will terminate (“Vesting of Equity”): 

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          (i)     Employee   shall not be eligible for any Vesting of Equity upon the termination of   Employee’s employment pursuant to Section 5.2 (Due to Disability),   Section 5.3 (Without Cause) or Section 5.6 (For Good Reason) until such date   which is 90 days after the Start Date.    On and after the 90th day following the Start Date,   Employee shall be eligible for Vesting of Equity as to the first 20% of the   unvested options or restricted stock of the Company held by the Employee   (determined by date of grant) upon termination of Employee’s employment   pursuant to Section 5.2 (Due to Disability), Section 5.3 (Without Cause)   or Section 5.6 (For Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (ii)    on   and after the first anniversary of the Start Date, Employee shall be eligible   for Vesting of Equity as to the first 30% of the unvested options or   restricted stock of the Company held by the Employee (determined by date of   grant) upon termination of Employee’s employment pursuant to Section 5.2 (Due   to Disability), Section 5.3 (Without Cause) or Section 5.6 (For   Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (iii)   on   and after the second anniversary of the Start Date, Employee shall be   eligible for Vesting of Equity as to the first 50% of the unvested options or   restricted stock of the Company held by the Employee (determined by date of   grant) upon termination of Employee’s employment pursuant to Section 5.2 (Due   to Disability), Section 5.3 (Without Cause) or Section 5.6 (For   Good Reason);
  
	
   
  	
  
 
  
	
  
 
  	
  
          (iv)   on   and after the third anniversary of the Start Date, Employee shall be eligible   for Vesting of Equity as to the first 70% of the unvested options or   restricted stock of the Company held by the Employee (determined by date of   grant) upon termination of Employee’s employment pursuant to Section 5.2 (Due   to Disability), Section 5.3 (Without Cause) or Section 5.6 (For   Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (v)    on   and after the fourth anniversary of the Start Date, Employee shall be   eligible for Vesting of Equity as to the first 90% of the unvested options or   restricted stock of the Company held by the Employee (determined by date of   grant) upon termination of Employee’s employment pursuant to Section 5.2 (Due   to Disability), Section 5.3 (Without Cause) or Section 5.6 (For   Good Reason); and
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (vi)   on   and after the fifth anniversary following the Start Date, Employee shall be   eligible for Vesting of Equity as to 100% of the unvested options or   restricted stock of the Company held by the Employee upon termination of   Employee’s employment pursuant to Section 5.2 (Due to Disability),   Section 5.3 (Without Cause) or Section 5.6 (For Good Reason).
  

                     Notwithstanding the foregoing, in the event Employee terminates employment for Good Reason during the thirty (30) days following the first anniversary of a Change in Control pursuant to Section 5.6, Employee shall be eligible for Vesting of Equity as to 100% of the unvested options or restricted stock of the Company held by the Employee upon termination of Employee’s employment.

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                     (c)     Benefits.  In addition to the Severance Payments and the Vesting, provided that Employee is eligible for and timely elects COBRA healthcare coverage continuation, the Company shall reimburse Employee (upon Employee providing proof of payment satisfactory to the Company) for the portion of the COBRA premium equal to the difference between the COBRA premium and Employee’s monthly contribution towards health care benefits immediately prior to the date of termination, for Employee to continue his (and, if applicable, his family’s) health care coverage, which was in effect as of the date of termination for up to eighteen (18) months from the date of termination but only until Employee becomes eligible for health care benefits (similar to such health care benefits received by Employee immediate
ly prior to the date of termination) from any other employer, provided that Employee (and, if applicable, his family) remains eligible for such coverage (the “Severance Benefits”).  Notwithstanding the foregoing, the Company’s payment of portions of the COBRA premium shall be delayed to the extent necessary to comply with Section 409A of the Code.  

                    (d)     Limitation on Eligibility for Severance Amount.  Employee shall be eligible for the portion of the Severance Amount, payable upon the termination of Employee’s employment pursuant to Section 5.2 (Due to Disability), Section 5.3 (Without Cause) or Section 5.6 (For Good Reason), as set forth below:

	
  
 
  	
  
          (i)     Employee   shall not be eligible for any portion of the Severance Amount, payable upon   the termination of Employee’s employment pursuant to Section 5.2 (Due to   Disability), Section 5.3 (Without Cause) or Section 5.6 (For Good   Reason), until such date which is 90 days after the Start Date.  On and after the 90th day   following the Start Date, Employee shall be eligible for 20% of the Severance   Amount upon termination of Employee’s employment pursuant to Section 5.2 (Due   to Disability), Section 5.3 (Without Cause) or Section 5.6 (For   Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (ii)    on   and after the first anniversary of the Start Date, Employee shall be eligible   for 30% of the Severance Amount upon termination of Employee’s employment   pursuant to Section 5.2 (Due to Disability), Section 5.3 (Without Cause)   or Section 5.6 (For Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (iii)   on   and after the second anniversary of the Start Date, Employee shall be   eligible for 50% of the Severance Amount upon termination of Employee’s   employment pursuant to Section 5.2 (Due to Disability), Section 5.3   (Without Cause) or Section 5.6 (For Good Reason);
  
	
   
  	
  
 
  
	
  
 
  	
  
          (iv)   on   and after the third anniversary of the Start Date, Employee shall be eligible   for 70% of the Severance Amount upon termination of Employee’s employment   pursuant to Section 5.2 (Due to Disability), Section 5.3 (Without Cause)   or Section 5.6 (For Good Reason);
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (v)    on   and after the fourth anniversary of the Start Date, Employee shall be   eligible for 90% of the Severance Amount upon termination of Employee’s   employment pursuant to Section 5.2 (Due to Disability), Section 5.3   (Without Cause) or Section 5.6 (For Good Reason); and
  
	
  
 
  	
  
 
  
	
  
 
  	
  
          (vi)  on and after the fifth anniversary of the   Start Date, Employee shall be eligible for 100% of the Severance Amount upon   termination of Employee’s employment pursuant to Section 5.2 (Due to   Disability), Section 5.3 (Without Cause) or Section 5.6 (For Good   Reason).
  

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                    Notwithstanding the foregoing, in the event Employee terminates employment for Good Reason during the thirty (30) days following the first anniversary of a Change in Control pursuant to Section 5.6, Employee shall be eligible for 100% of the Severance Amount upon termination of Employee’s employment.

          5.8     Change in Control.  

          For purposes of this Agreement, a “Change in Control” shall mean the occurrence of any of the following events: 

                    (a)     the individuals constituting the Board as of the Effective Date (the “Incumbent Board”) cease for any reason to constitute at least two-thirds (2/3rds) of the Board; provided, however, that if the election, or nomination for election by the Company’s stockholders, of any new director was approved by a vote of at least two-thirds (2/3rds) of the Incumbent Board, such new director shall be considered a member of the Incumbent Board; or

                    (b)     an acquisition of any voting securities of the Company (the “Voting Securities”) by any “person” (as the term “person” is used for purposes of Section 13(d) or Section 14(d) of the Securities Exchange Act of 1934, as amended (the “1934 Act”)) immediately after which such person has “beneficial ownership” (within the meaning of Rule 13d-3 promulgated under the 1934 Act) (“Beneficial Ownership”) of thirty five (35) percent or more of the combined voting power of the Company’s then outstanding Voting Securities; or

                    (c)     approval by the stockholders of the Company of:

                              (i)     a merger, consolidation, share exchange or reorganization involving the Company, unless

	
  
 
  	
  
                 (A)     the   stockholders of the Company, immediately before such merger, consolidation,   share exchange or reorganization, own, directly or indirectly immediately   following such merger, consolidation, share exchange or reorganization, at   least sixty-five (65) percent of the combined voting power of the outstanding   voting securities of the corporation that is the successor in such merger,   consolidation, share exchange or reorganization (the “Surviving Company”)   in substantially the same proportion as their ownership of the Voting   Securities immediately before such merger, consolidation, share exchange or   reorganization; provided, however, that a merger, consolidation, share   exchange or reorganization of the Company shall not constitute a Change in Control   if such merger, consolidation, share exchange or
reorganization of the   Company is approved by the Board and is recommended by Employee to the Board   for its approval; and
  

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                 (B)     the   individuals who were members of the Incumbent Board immediately prior to the   execution of the agreement providing for such merger, consolidation, share   exchange or reorganization constitute at least two-thirds (2/3rds) of the   members of the board of directors of the Surviving Company; or
  

                              (ii)     a complete liquidation or dissolution of the Company; or

                              (iii)    an agreement for the sale or other disposition of all or substantially all of the assets of the Company.

          5.9     Vesting Upon Change in Control.  

          Notwithstanding the provisions of any plan or agreement to the contrary, upon a Change in Control, all unvested stock options held by Employee shall be fully vested and exercisable, and all restricted stock held by Employee shall be fully vested.  Except as expressly set forth in this Section 5.9, such stock options and restricted stock shall be subject to the terms of the plans and agreements under which they were issued.

6.       CONFIDENTIALITY

          During the Term, Employee will have access to and become acquainted with various information relating to the Company’s business operations, including customer (meaning a broker or borrower) lists, customer files, marketing data, business plans, strategies, employee lists, contracts, financial records and accounts, projections and budgets, and similar information.  Employee agrees that to the extent such information is not generally known to or available to the public and/or the industry, and gives the Company an advantage over competitors who do not know of or use such information, such information and documents constitute “Confidential Information” of the Company.  Employee further agrees that any documents relating to the business of the Company, whether they are prepared by Employee or come into Employee’s possession in any other way, are owned by the Company, shall
remain the exclusive property of the Company, and must be returned to the Company upon termination of employment.  Employee shall not use any Confidential Information of the Company, directly or indirectly, for Employee’s own benefit, or the benefit of any person or entity other than the Company, nor shall Employee disclose Confidential Information to any person or entity other than the Company and its employees, either during the Term or at any time thereafter, except as may be appropriate for Employee to perform his duties as an employee, officer and/or director, directly or indirectly, of the Company.  In the event Employee violates this provision during any period in which he is receiving severance under Section 5.7 of this Agreement, in addition to any other remedies the Company may have, the Company may terminate the Severance Payments, Vesting and Severance Benefits under Section 5.7.  

7.       NON-SOLICITATION/NON-COMPETITION

          7.1     Non-Solicitation.  For a period of one year following the date Employee’s employment hereunder is terminated, Employee shall not solicit or induce any of the Company’s employees, agents or independent contractors to end their relationship with the Company, or recruit, solicit or otherwise induce any such person to perform services for Employee, or any other person, firm or company.  The restrictions set forth in this Section 7 shall not apply if Employee’s employment is terminated pursuant to Section 5.3, 5.6 or 5.8.

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          7.2     Non-Competition.  Employee acknowledges that IsoTis does business throughout the world.  During the Term, and, if Employee is receiving severance under Section 5.7 of this Agreement, for the “Non-Compete Period” as defined below, Employee shall not, directly or indirectly, serve as an employee, consultant, officer, director, lender, investor, shareholder, partner, manager or member of any person or entity, or own or act as a sole proprietor of a business that engages in the production of natural or synthetic bone regeneration products, or similar business, during that period in any County of the State of California, any of the States of the United States of America, any country in Europe, other than the Company or its affiliates, or as approved in advance in writing by the Board; provided, however, that ownership of less than one (1) percent
of the publicly traded securities of any publicly traded entity shall not violate this provision.  In the event Employee violates this provision during any period in which he is receiving severance under Section 5.7 of this Agreement, in addition to any other remedies the Company may have, the Company may terminate the Severance Payments, Vesting and Severance Benefits under Section 5.7.  Employee acknowledges that these restrictions shall not prevent or unduly restrict Employee from practicing his profession, or cause him economic hardship.

          For purposes of this Section 7.2, the “Non-Compete Period” shall mean the number of months equal to the number obtained by multiplying (a) the quotient obtained by dividing (i) the portion of the Severance Amount payable to Employee upon termination of employment by, (ii) the total Severance Amount, by (b) twelve.

8.       ARBITRATION AGREEMENT

          8.1     Claims Subject to Arbitration.  Any controversy, dispute or claim between Employee and the Company, or its parents, subsidiaries, affiliates and any of their officers, directors, agents or other employees, shall be resolved by binding arbitration, at the request of either party.

          The arbitrability of any controversy, dispute or claim under this policy shall be determined by application of the substantive provisions of the Federal Arbitration Act (9 U.S.C. sections 1 and 2) and by application of the procedural provisions of the California Arbitration Act, except as provided herein.  Arbitration shall be the exclusive method for resolving any dispute and all remedies available from a court of competent jurisdiction shall be available; provided, however, that either party may request provisional relief from a court of competent jurisdiction, as provided in California Code of Civil Procedure Section 1281.8, if such relief is not available in a timely fashion through arbitration.

          The claims which are to be arbitrated include, but are not limited to any Claim arising out of or relating to this Agreement or the employment relationship between Employee and the Company, claims for wages and other compensation, claims for breach of contract (express or implied), claims for violation of public policy, wrongful termination, tort claims, claims for unlawful discrimination and/or harassment (including, but not limited to, race, religious creed, color, national origin, ancestry, physical disability, mental disability, gender identity or expression, medical condition, marital status, age, pregnancy, sex or sexual orientation) to the extent allowed by law, and claims for violation of any federal, state, or other government law, statute, regulation, or ordinance, except for claims for workers’ compensation and unemployment insurance benefits.  This Agreement shall not be interpreted
to provide for arbitration of any dispute that does not constitute a claim recognized under applicable law. 

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          8.2     Selection of Arbitrator.  The Employee and the Company will select a single neutral arbitrator by mutual agreement.  If the Employee and the Company are unable to agree on a neutral arbitrator within thirty (30) days of a demand for arbitration, either party may elect to obtain a list of arbitrators from the Judicial Arbitration and Mediation Service (“AMS”) or the American Arbitration Association (“AAA”), and the arbitrator shall be selected by alternate striking of names from the list until a single arbitrator remains.  The party initiating the arbitration shall be the first to strike a name.

          8.3     Demand for Arbitration.  The demand for arbitration must be in writing and must be made by the aggrieved party within the statute of limitations period provided under applicable State and/or Federal law for the particular claim(s).  Failure to make a written demand within the applicable statutory period constitutes a waiver of the right to assert that claim in any forum.  

          8.4     Location of Arbitration.  Arbitration proceedings will be held in Orange County, California.

          8.5     Choice of Law.  The arbitrator shall apply applicable State and/or Federal substantive law to determine issues of liability and damages regarding all claims to be arbitrated, and shall apply the California Evidence Code to the proceeding.  

          8.6     Discovery.  The parties shall be entitled to conduct reasonable discovery and the arbitrator shall have the authority to determine what constitutes reasonable discovery.  The arbitrator shall hear motions for summary judgment/adjudication as provided in the California Code of Civil Procedure.

          8.7     Written Opinion and Award.  Within thirty days following the hearing and the submission of the matter to the arbitrator, the arbitrator shall issue a written opinion and award which shall be signed and dated.  The arbitrator’s award shall decide all issues submitted by the parties, and the arbitrator may not decide any issue not submitted.  The opinion and award shall include factual findings and the reasons upon which the decision is based.  The arbitrator shall be permitted to award only those remedies in law or equity which are requested by the parties and allowed by law.

          8.8     Appeals.  The final award may be appealed to another arbitrator who will be chosen by the parties in the same manner as the original arbitrator.  All the rules governing judicial appeals of judgments from the Superior Court of the State of California shall apply to any appeal of this award, including but not limited to the time frames, deadlines and the standards of review.  

          8.9     Costs of Arbitration.  The cost of the arbitrator and other incidental costs of arbitration that would not be incurred in a court proceeding shall be borne by the Company.  The parties shall each bear their own costs and attorneys’ fees in any arbitration proceeding, provided, however, that the arbitrator shall have the authority to require either party to pay the costs and attorneys’ fees of the other party to the extent permitted under applicable federal or state law, as a part of any remedy that may be ordered.

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          8.10    Waiver of Right to Jury.  Both the Company and Employee understands that by using arbitration to resolve disputes they are giving up any right that they may have to a judge or jury trial with regard to all issues concerning employment or otherwise covered by this Section 8.

9.       GENERAL PROVISIONS

          9.1     Assignment; Binding Effect.  Neither the Company nor Employee may assign, delegate or otherwise transfer this Agreement or any of their respective rights or obligations hereunder without the prior written consent of the other party.  Any attempted prohibited assignment or delegation shall be void.  This Agreement shall be binding upon and inure to the benefit of any permitted successors or assigns of the parties and the heirs, executors, administrators and/or personal representatives of Employee.

          9.2     Notices.  All notices, requests, demands and other communications that are required or may be given under this Agreement shall be in writing and shall be deemed to have been duly given when received if personally delivered; when transmitted if transmitted by telecopy, electronic or digital transmission method with electronic confirmation of receipt; the day after it is sent, if sent for next-day delivery to a domestic address by recognized overnight delivery service (e.g.,  FedEx); and upon receipt, if sent by certified or registered mail, return receipt requested.  In each case notice shall be sent to:

	
  
If to the   Company:
  	
  
IsoTis SA
  
	
  
 
  	
  
2 Goodyear
  
	
  
 
  	
  
Irvine, CA   92618
  
	
   
  	
  
Attention:  Chief Executive Officer
  
	
  
 
  	
  
Facsimile:   (949) 595-8717
  
	
  
 
  	
  
 
  
	
  
If to   Employee:
  	
  
Kathe   Liljestrand
  
	
  
 
  	
  
c/o IsoTis   SA
  
	
  
 
  	
  
2 Goodyear
  
	
  
 
  	
  
Irvine, CA   92618
  
	
  
 
  	
  
Fax: (949)   595-8703
  

          Any party may change its address for the purpose of this Section 9.2 by giving the other party written notice of its new address in the manner set forth above.

          9.3     Entire Agreement.  This Agreement constitutes the entire agreement of the parties with respect to the subject matter hereof, and supersedes all prior agreements; provided, however, that this Agreement shall supplement, not supercede, any prior agreements concerning the Confidential Information, Trade Secrets or other intellectual property of the Company, and any conflicts or inconsistencies between such agreements shall be resolved so that the provision providing greater rights to the Company shall prevail.   

          9.4     Amendments; Waivers.  This Agreement may be amended or modified, and any of the terms and covenants may be waived, only by a written instrument executed by the parties hereto, or, in the case of a waiver, by the party waiving compliance.  Any waiver by any party in any one or more instances of any term or covenant contained in this Agreement shall neither be deemed to be nor construed as a further or continuing waiver of any such term or covenant of this Agreement.

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          9.5     Provisions Severable.  In case any one or more provisions of this Agreement shall be invalid, illegal or unenforceable, in any respect, the validity, legality and enforceability of the remaining provisions contained herein shall not, in any way, be affected or impaired thereby.  If any provision hereof is determined by any court of competent jurisdiction to be invalid or unenforceable by reason of such provision extending the covenants and agreements contained herein for too great a period of time or over too great a geographical area, or being too extensive in any other respect, such provision shall be interpreted to extend only over the maximum period of time and geographical area, and to the maximum extent in all other respects, as to which it is valid and enforceable, all as determined by such court in such action.

          9.6     Attorney’s Fees.  If any legal action, arbitration or other proceeding, is brought for the enforcement of this Agreement, or because of an alleged dispute, breach or default in connection with any of the provisions of this Agreement, each of the parties hereto shall be responsible for payment of their own attorneys’ fees and other costs incurred by them in that action or proceeding, without regard to whomever is the prevailing party in such action or proceeding with respect to such claims, except as otherwise provided in Section 8.

          9.7     Governing Law.  This Agreement shall be construed, performed and enforced in accordance with, and governed by the laws of the State of California without giving effect to the principles of conflict of laws thereof.

          9.8     Non-Disparagement.  During his/her employment and thereafter, Employee agrees to represent the Company in a positive light and not to disparage or in any other way communicate to any person or entity any negative information or opinion concerning the Company, its parents, subsidiaries and affiliates, or any of their partners, members, shareholders, officers, directors, employees or agents, or any of them.   This provision shall not prohibit Employee from making any statements or taking any actions required by law, or reporting any actions or inactions Employee believes to be unlawful.  This provision shall not be interpreted to require or encourage Employee to make any misrepresentations. 

          9.9     Return of Property.  Upon termination of Employee’s employment, Employee shall return to the Company any and all company property, materials, or equipment in his or her possession, including, without limitation, Company property described in Section 6.

          9.10   Cooperation.  During Employee’s employment with the Company and thereafter,  Employee agrees to cooperate with Employer and Employer’s agents, accountants and attorneys concerning any matter with which Employee was involved during his/her employment.  Such cooperation shall include, but not be limited to, providing information to, meeting with and reviewing documents provided by Employer and Employer’s agents, accountants and attorneys during normal business hours or other mutually agreeable hours upon reasonable notice and to make himself/herself available for depositions and hearings, if necessary and upon reasonable notice.  If Employee’s cooperation is required after the termination of Employee’s employment, the Company shall reimburse Employee for any out of pocket expenses incurred in and any wages lost by Employee for time
spent performing his/her obligations hereunder.

12

          9.11   Counterparts.  This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which shall constitute the same instrument.

          9.12   Headings.  The headings contained in this Agreement are provided solely for the Parties’ convenience and shall not be deemed to alter the meaning of the text of the Agreement. 

          9.13   Survival.  Sections 6, 7, 8, and 9 shall survive the termination of this Agreement.

          IN WITNESS WHEREOF, the parties hereto have executed this Agreement effective as of the date first written above.

	
  
THE COMPANY:
  	
  
 
  	
  
 
  
	

	
  
 
  	
  
 
  
	
  IsoTis SA,
  	
  
 
  	
  
 
  
	
  
a  Swiss corporation
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
 
  	
  
 
  
	
  
By:
  	
  
/s/ Pieter   Wolters
  	
  
 
  	
  
July 26,   2005
  
	
  
 
  	
  

  	
  
 
  	
  
Date
  
	
  
 
  	
  
Pieter   Wolters
  	
  
 
  	
  
 
  
	
  
 Its:  
  	
  
President & Chief Executive Officer
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
 
  	
  
 
  
	
  
EMPLOYEE:
  	
  
 
  	
  
 
  
	

   	  
	  

	
  
 
  	
  
/s/ Kathryn   Liljestrand
  	
  
 
  	
  
July 26,   2005
  
	
  
 
  	
  

  	
  
 
  	
  
Date
  
	
  
 
  	
  
Kathryn   Liljestrand
  	
  
 
  	
  
 
  

13EXHIBIT 4.15

February 17, 2006

Alan Donze
 245 Coast Boulevard
 Suite B-1
 La Jolla, CA 92037

Dear Alan:

It is my pleasure to offer you a position with IsoTis OrthoBiologics, Inc., based in Irvine, California. 

As you know, this organization brings a variety of opportunities and challenges that are expected to pay off significantly for everyone with a positive, entrepreneurial attitude who achieves outstanding results. Our future success depends on the achievement of outstanding individual, division, and corporate results and I feel your contribution will be mutually rewarding. 

This letter describes the outlines of your employment and compensation, which will be further and definitely defined in a standard Management Team employment agreement to be signed by both parties.

	
  
EMPLOYMENT:
  	
  
 
  
	
  
 
  	
  
 
  
	
  
Your start date will be:
  	
  
February 21, 2007.
  

This is a full-time, exempt, regular position: Vice President of Sales reporting to Pieter Wolters, President & CEO.

COMPENSATION

	
  
 
  	
  
1. Compensation Level #1:
  	
  
 
  	
  
$200,000.  Annualized Base Salary, (payable on a   bi-weekly basis)
  
	
  
 
  	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
2. Compensation Level #2:
  	
  
 
  	
  
Potential bonus of   $120,000.00 sales commission for 2006.    The program is based on corporate objectives as laid out in the bonus   program. At year end 2006 a $30,000 corporate bonus at the discretion of the   CEO.
  
	
  
 
  	
  
 
  	
  
 
  	
  
 
  
	
   
  	
  
3. Compensation Level #3:
  	
  
 
  	
  
$500.  Monthly Auto Allowance.
  
	
  
 
  	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
4. Compensation Level #4:
  	
  
 
  	
  
300,000 Stock options, to be granted with an   exercise price equal to the average SWX closing price of the 5 trading days   preceding February 21, 2006.  You will   receive copies of the stock option plan and an award agreement describing the   terms and conditions of these options after your employment begins.  IsoTis options are administered by an   electronic data system of the UBS Bank, and you will receive information on   how to access this system from the UBS bank directly.
  

BENEFITS

You will be eligible to begin participating in the IsoTis benefits program starting first of the month after 30 days of employment. Benefits include medical, dental, vision, Long Term Disability, 401K and life insurance. IsoTis will pay for the health care premiums for you and your dependents (medical, dental, vision, Long Term Disability, life insurance).  IsoTis provides all full-time employees with 11 company paid holidays. You will accrue four weeks (20 days) of paid time off (PTO) annually.

CONTINGENCIES

This offer of employment is contingent upon the following:

	
  
 
  	
  
•
  	
  
Satisfactory completion   of a background check
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
•
  	
  
Your ability to provide   proof of citizenship and/or right to work documentation no later than close   of business on you first day of employment.    Please refer to the list of acceptable forms of documentation as   described on the I-9 form to be provided;
  
	
  
 
  	
  
 
  	
  
 
  
	
  
 
  	
  
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Your completion of the   IsoTis Confidentiality Agreement. A copy of this document has been attached   and should be completed and submitted to the Human Resources Department on   your first day of employment;
  
	
   
  	
  
 
  	
  
 
  
	
  
 
  	
  
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Please bring your Social   Security Card on the first day of employment for payroll verification.
  

IsoTis OrthoBiologics, Inc is an at-will employer, and cannot guarantee employment for any specific duration. You are free to resign, and IsoTis is entitled to terminate your employment at any time, with or without cause. This provision can only be changed or revoked by the CEO, and cannot be changed by any express or implied agreement based on statements or action by any employee or supervisor.

This letter sets forth the entire agreement between you and IsoTis. Once signed by you, it will become a legally binding and will supersede all prior discussions, promises, and negotiations.

To accept this offer, simply sign in the space provided below and confirm your anticipated start date. Please fax a signed copy of this letter to me at (949) 595-8703, and return the original signed letter by mail or in person.   

Alan, I am very pleased to welcome you to the IsoTis team. Please do not hesitate to contact me if you have any questions.

	
  
Sincerely,
  	
  
 
  	
  
 
  
	
   
  	
  
 
  	
  
 
  
	
  
/s/ Pieter Wolters
  	
  
 
  	
  
 
  
	
  

  	
  
 
  	
  
 
  
	
  
Pieter Wolters
  	
  
 
  	
  
 
  
	
  
President & CEO
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
 
  
	
  
I agree to the terms   stated in this letter.
  	
  
 
  	
  
 
  
	
  
 
  	
  
 
  	
  
 
  
	
  /s/ Alan Donze
  	
   
  	
  February 17, 2006
  
	
  

  	
   
  	
  Date
  
	
  Alan Donze

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