Document:

EX-10.1

 Exhibit 10.1 

IMAGO BIOSCIENCES, INC. 

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

November 12, 2020 
  

 TABLE OF CONTENTS 

 

									
	 	 	 	  	 	  	Page	 
			
	1.        	 	 Registration Rights
	  	 	1	 
		 	1.1	  	 Definitions
	  	 	1	 
		 	1.2	  	 Request for Registration
	  	 	4	 
		 	1.3	  	 Company Registration
	  	 	5	 
		 	1.4	  	 Obligations of the Company
	  	 	6	 
		 	1.5	  	 Furnish Information
	  	 	7	 
		 	1.6	  	 Expenses of Registration
	  	 	7	 
		 	1.7	  	 Delay of Registration
	  	 	8	 
		 	1.8	  	 Indemnification
	  	 	8	 
		 	1.9	  	 Reports Under Exchange Act
	  	 	10	 
		 	1.10	  	 Form S-3 Registration
	  	 	11	 
		 	1.11	  	 Assignment of Registration Rights
	  	 	11	 
		 	1.12	  	 Termination of Registration Rights
	  	 	12	 
		 	1.13	  	 Limitations on Subsequent Registration Rights
	  	 	12	 
			
	2.	 	 Market Stand-off Agreement
	  	 	12	 
			
	3.	 	 Covenants of the Company
	  	 	13	 
		 	3.1	  	 Delivery of Financial Statements
	  	 	13	 
		 	3.2	  	 Matters Requiring Investor Director Approval
	  	 	14	 
		 	3.3	  	 Inspection
	  	 	15	 
		 	3.4	  	 Right of First Offer
	  	 	15	 
		 	3.5	  	 Confidential Information and Invention Assignment and
Non-Solicitation Agreements
	  	 	16	 
		 	3.6	  	 Indemnification
	  	 	16	 
		 	3.7	  	 Directors’ & Officers’ Liability
	  	 	17	 
		 	3.8	  	 Key-Man Life Insurance
	  	 	17	 
		 	3.9	  	 Board Matters
	  	 	17	 
		 	3.10    	  	 Board Committees
	  	 	17	 
		 	3.11	  	 Stock Vesting
	  	 	17	 
		 	3.12	  	 Observer Rights
	  	 	18	 
		 	3.13	  	 Confidentiality
	  	 	19	 
		 	3.14	  	 Brokers or Finders
	  	 	20	 
		 	3.15	  	 Maintenance of Corporate Existence
	  	 	20	 
		 	3.16	  	 Further Assurances
	  	 	20	 
		 	3.17	  	 Protection of Intellectual Property
	  	 	20	 
		 	3.18	  	 Reservation of Common Stock
	  	 	20	 
		 	3.19	  	 Defense Production Act
	  	 	20	 
		 	3.20	  	 Right to Conduct Activities
	  	 	20	 
		 	3.21	  	 FCPA
	  	 	21	 
		 	3.22	  	 Successor Indemnification
	  	 	21	 
		 	3.24	  	 Termination of Covenants
	  	 	21	 

  
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	4.        	 	 Restrictions on Transferability of Securities; Compliance with Securities
Act
	  	 	22	 
		 	4.1	  	 Restrictions on Transferability
	  	 	22	 
		 	4.2	  	 Notice of Proposed Transfers
	  	 	22	 
			
	5.	 	 Miscellaneous
	  	 	23	 
		 	5.1	  	 Successors and Assigns
	  	 	23	 
		 	5.2	  	 Governing Law
	  	 	23	 
		 	5.3	  	 Venue
	  	 	23	 
		 	5.4	  	 Counterparts
	  	 	23	 
		 	5.5	  	 Titles and Subtitles
	  	 	24	 
		 	5.6	  	 Notices
	  	 	24	 
		 	5.7	  	 Amendments and Waivers
	  	 	25	 
		 	5.8	  	 Severability
	  	 	25	 
		 	5.9	  	 Additional Parties
	  	 	25	 
		 	5.10    	  	 Delays or Omissions
	  	 	26	 
		 	5.11	  	 Aggregation of Stock
	  	 	26	 
		 	5.12	  	 Advice of Counsel
	  	 	26	 
		 	5.13	  	 Entire Agreement
	  	 	26	 

 Schedule A Schedule of Investors 
  

  
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 AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”) is made as of November 12, 2020, by and
among Imago BioSciences, Inc., a Delaware corporation (the “Company”) and the investors listed on the Schedule of Investors attached as Schedule A hereto (each an “Investor” and collectively, the
“Investors”). 
 WHEREAS, certain Investors (the “Existing Investors”) holding shares of the
Company’s Series A Preferred Stock and Series B Preferred Stock possess certain rights pursuant to that certain Amended and Restated Investors’ Rights Agreement, dated as of March 15, 2019, by and among the Company and the Existing
Investors (the “Prior Agreement”). 
 WHEREAS, the Company and certain of the Investors (the “Series C
Investors”) are parties to that certain Series C Preferred Stock Purchase Agreement of even date herewith (as amended and/or restated from time to time, the “Purchase Agreement”) by and among the Company and the Investors,
pursuant to which the Investors are purchasing shares of the Company’s Series C Preferred Stock, par value $0.0001 per share (the “Series C Preferred Stock”). 

WHEREAS, in order to induce the Series C Investors to purchase the Company’s Series C Preferred Stock, the Existing Investors and the
Company desire to amend and restate the Prior Agreement, including the rights and obligations set forth therein, in each as set forth herein. 

NOW, THEREFORE, the parties hereto hereby agree as follows: 

1. Registration Rights. The Company covenants and agrees as follows: 

1.1 Definitions. For purposes of this Agreement: 

(a) “Acquisition” has the meaning ascribed to such term in the Restated Certificate. 

(b) “Affiliate” means, with respect to any specified person, any other person who, directly or indirectly, controls, is
controlled by, or is under common control with such person, including, without limitation, any general partner, managing member, officer, director or trustee of such person, or any venture capital fund or other investment fund now or hereafter
existing that is controlled by one (1) or more general partners, managing members or investment adviser of, or shares the same management company or investment adviser with, such person. 

(c) “Board” means the Board of Directors of the Company. 

(d) “Common Stock” means shares of the Company’s common stock, par value $0.0001 per share. 

(e) “Convertible Securities” means any bonds, debentures, notes or other evidences of indebtedness, and any options,
warrants, shares (including, but not limited to, shares of Preferred Stock) purchase rights or any other securities convertible into, exercisable for, or exchangeable for Common Stock. 

  
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 (f) “Exchange Act” means the Securities Exchange Act of 1934, as amended,
or any similar successor federal statute, and the rules and regulations thereunder, all as the same shall be in effect from time to time. 

(g) “Form S-3” means such form under the Securities Act as in effect on the date
hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

(h) “Holder” means any person owning or having the right to acquire Registrable Securities or any assignee thereof in
accordance with Section 1.11 of this Agreement. 
 (i) “Initiating Holders” means any Holder or Holders who in
the aggregate hold at least sixty-five percent (65%) of the Registrable Securities then outstanding. 
 (j) “IPO” means a
public offering of the Common Stock of the Company to the general public that is effected pursuant to a registration statement filed with, and declared effective by, the SEC under the Securities Act in connection with which all outstanding shares of
Preferred Stock will be converted to Common Stock. 
 (k) “Major Investor” means any Investor, individually or together
with such Investor’s Affiliates, holding at least 8,208,705 shares of Registrable Securities (as appropriately adjusted for any stock split, dividend, combination or other recapitalization or like transaction) and each Person to whom any of the
rights of any such Investor are assigned pursuant to Sections 4.2 and 5.1. 
 (l) “Preferred Director
Approval” means the affirmative vote or written consent of a majority of the then-serving Preferred Directors (as defined in the Restated Certificate), if any. 

(m) “Preferred Stock” means, collectively and individually, the Series A Preferred Stock, Series B Preferred Stock and
Series C Preferred Stock. 
 (n) “Pro Rata Share” means, with respect to an Investor, that proportion that the number of
shares of Common Stock issued and held, or issuable upon conversion of the Preferred Stock then held, by such Investor bears to the total number of shares of Common Stock of the Company then outstanding (assuming full conversion of all outstanding
convertible securities). 
 (o) The terms “register,” “registered” and “registration”
refer to a registration effected by preparing and filing a registration statement or similar document in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 

(p) “Registrable Securities” means (i) the Common Stock issuable or issued upon conversion of the Preferred Stock; and
(ii) any Common Stock of the Company issued as (or issuable upon conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to or in exchange for or in replacement of
the 

  
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shares referenced in clause (i) above; provided, however, that shares of Common Stock or other securities shall only be treated as Registrable Securities if and so long as they
have not been (A) sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction, (B) sold in a transaction exempt from the registration and prospectus delivery requirements
of the Securities Act under Section 4(1) thereof so that all transfer restrictions and restrictive legends with respect thereto are removed upon the consummation of such sale or (C) transferred in a transaction pursuant to
which the registration rights are not also assigned in accordance with Section 1.11 hereof. 
 (q) The number of shares of
“Registrable Securities then outstanding” shall be the sum of the number of shares of Common Stock outstanding that are, and the number of shares of Common Stock issuable pursuant to then exercisable or convertible securities that
are, Registrable Securities. 
 (r) “Restated Certificate” means the Company’s Amended and Restated Certificate of
Incorporation, as filed with the Secretary of State of Delaware on or about the date hereof, as amended and/or restated from time to time. 

(s) “Restricted Securities” means the securities of the Company required to bear the legend set forth in Section 3.6 of
the Purchase Agreement. 
 (t) “Rule 144” means Rule 144 as promulgated by the SEC under the Securities Act, as such Rule
may be amended from time to time, or any similar successor rule that may be promulgated by the SEC. 
 (u) “SEC” shall
mean the Securities and Exchange Commission. 
 (v) “Securities Act” means the Securities Act of 1933, as amended, or any
similar successor federal statute, and the rules and regulations thereunder, all as the same shall be in effect from time to time. 
 (w)
“Series A Preferred Stock” means the Series A Preferred Stock of the Company, par value $0.0001 per share. 
 (x)
“Series B Preferred Stock” means the Series B Preferred Stock of the Company, par value $0.0001 per share. 
 (y)
“Significant Investor” means (A) any Investor, individually or together with such Investor’s Affiliates, holding (i) at least five percent (5%) of the then-outstanding Registrable Securities (as appropriately adjusted for any
stock split, dividend, combination or other recapitalization or like transaction) (together with its Affiliates, a “5% Holder”), (ii) any shares of Series B Preferred Stock or (iii) at least 8,208,705 shares of Registrable
Securities (as appropriately adjusted for any stock split, dividend, combination or other recapitalization or like transactions); provided, however, that notwithstanding the foregoing (including, for clarity, notwithstanding an Investor’s
holding any shares of Series B Preferred Stock pursuant to clause (ii) of this section), no 5% Holder shall be deemed a Significant Investor hereunder if such 5% Holder does not purchase, pursuant to the Purchase Agreement, a number of shares of
Series C Preferred Stock equal to at least the lesser of (x) such 5% Holder’s Pro Rata Share of 16,559,032 shares of Series C Preferred Stock or (y) $500,000 and (B) each Person to whom any of the rights of any such Significant Investor
are assigned pursuant to Sections 4.1 and 5.1. 

  
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 1.2 Request for Registration. 

(a) Subject to the conditions of this Section 1.2, if the Company shall receive at any time after the earlier of
(i) November 12, 2025 or (ii) six months following the IPO, a written request from the Initiating Holders that the Company file a registration statement under the Securities Act covering the registration of Registrable Securities which
would have an aggregate offering price of not less than $15,000,000, then the Company shall within twenty (20) days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section
1.2, use commercially reasonable efforts to effect, as soon as practicable, the registration under the Securities Act of all Registrable Securities that the Holders request to be registered in a written request received by the Company within
twenty (20) days of the mailing of the Company’s notice pursuant to this Section 1.2(a). 
 (b) If the Initiating Holders
intend to distribute the Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Section 1.2(a) and the Company shall include such
information in the written notice referred to in Section 1.2(a). The underwriter will be selected by the Initiating Holders and shall be reasonably acceptable to the Company. In such event, the right of any Holder to include its
Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders
proposing to distribute their securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting. Notwithstanding any other provision of this
Section 1.2, if the underwriter advises the Initiating Holders in writing that marketing factors require a limitation of the number of shares to be underwritten, then the Company shall so advise all Holders of Registrable Securities
which would otherwise be underwritten pursuant hereto, and the number of shares of Registrable Securities that may be included in the underwriting shall be allocated, first, to the Initiating Holders and each Investor that participated in the
underwriting as a Holder on a pro rata basis based on the total number of Registrable Securities held by the Initiating Holders and participating Investors; and second, to any Holder on a pro rata basis among all such Holders. 

(c) Notwithstanding the foregoing, if the Company shall furnish to the Holders requesting a registration statement pursuant to this
Section 1.2 a certificate signed by the President of the Company stating that, in the good faith judgment of the Board, it would be detrimental to the Company and its stockholders for such registration statement to be filed and it is
therefore essential to defer the filing of such registration statement, the Company shall have the right to defer taking action with respect to such filing for a period of not more than ninety (90) days after receipt of the request of
the Initiating Holders; provided, however, that the Company may not utilize this right more than once in any twelve (12) month period. 

  
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 (d) In addition, the Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to this Section 1.2: 
 (i) after the Company has effected two (2) registrations pursuant
to this Section 1.2 and such registrations have been declared or ordered effective; 
 (ii) during the six-month period following the effective date of the registration statement pertaining to an IPO; 

(iii) if, within thirty (30) days of a registration request by the Initiating Holders, the Company gives notice to the Holders of its
intent to file a registration statement for an IPO within ninety (90) days; or 
 (iv) if the Initiating Holders propose to
dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 1.10 below. 

1.3 Company Registration. 

(a) If (but without any obligation to do so) the Company proposes to register (including for this purpose a registration effected by the
Company for stockholders other than the Holders) any of its stock or other securities under the Securities Act in connection with the public offering of such securities solely for cash (other than a registration relating solely to the sale of
securities to participants in a Company stock plan, registration on any form which does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities or
a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities which are also being registered), the Company shall, at such time, promptly give each Holder written notice of such
registration. Upon the written request of each Holder given within twenty (20) days after mailing of such notice by the Company in accordance with Section 5.6, the Company shall, subject to the provisions of
Section 1.3(b), cause to be registered under the Securities Act all of the Registrable Securities that each such Holder has requested to be registered. Registrations effected pursuant to this Section 1.3 shall not be counted
as demands for registration pursuant to Section 1.2. 
 (b) If the registration statement under which the Company gives notice
under this Section 1.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to be included in a registration pursuant to this
Section 1.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to
distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of
the Agreement, if the underwriter determines in good faith that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the
Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis. No such reduction
shall reduce the amount of securities of the selling Holders included in the registration below thirty percent (30%) of the total amount of securities included in such registration, unless such offering

  
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is the IPO and such registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance
with the immediately preceding sentence. For any Holder which is a partnership or corporation, the partners, retired partners and shareholders of such Holder, or the estates and lineal descendants of any such partners and retired partners and any
trusts for the benefit of any of the foregoing persons shall be deemed to be a single “Holder,” and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying
registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence. 
 (c) The
Company shall have the right to terminate or withdraw any registration initiated by it under this Section 1.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such
registration. 
 1.4 Obligations of the Company. 

(a) Whenever required under this Section 1 to effect the registration of any Registrable Securities, the Company shall, as
expeditiously as reasonably possible: 
 (i) Prepare and file with the SEC a registration statement with respect to such Registrable
Securities and use reasonable efforts to cause such registration statement to become effective, and, upon the request of the Holders of sixty-five percent (65%) of the Registrable Securities registered thereunder, keep such registration statement
effective for a period of up to 120 days, if earlier, until the distribution contemplated in the registration statement has been completed. 

(ii) Prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in connection with
such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement. 

(iii) Furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements
of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

(iv) Use reasonable efforts to register and qualify the securities covered by such registration statement under such other securities or Blue
Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided, that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent to
service of process, or subject itself to general taxation, in any such states or jurisdictions. 
 (v) In the event of any underwritten
public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering. Each Holder participating in such underwriting shall also enter into and perform
its obligations under such an agreement. 

  
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 (vi) Notify each Holder of Registrable Securities covered by such registration statement at
any time when a prospectus relating thereto is required to be delivered under the Securities Act or the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue
statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. 

(vii) Cause all such Registrable Securities registered pursuant hereunder to be listed on each securities exchange or nationally recognized
quotation system on which similar securities issued by the Company are then listed. 
 (viii) Provide a transfer agent and registrar for
all Registrable Securities registered pursuant hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

(ix) Reasonably cooperate in all necessary respects with (A) counsel in preparation of the customary legal opinions and
(B) accountants in preparation of the customary comfort letters, copies of which shall be provided to each Holder so requesting; provided that the Holders shall not be entitled to rely upon such legal opinions and comfort letters other
than in accordance with their own respective terms. 
 1.5 Furnish Information. 

(a) It shall be a condition precedent to the obligations of the Company to take any action pursuant to this Section 1 with
respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of disposition of such securities as shall be
required to effect the registration of such Holder’s Registrable Securities. 
 (b) The Company shall have no obligation with respect
to any registration requested pursuant to Section 1.2 or Section 1.10 if, due to the operation of Section 1.5(a), the number of shares of the Registrable Securities to be included in the registration does not equal or
exceed the number of shares required to originally trigger the Company’s obligation to initiate such registration as specified in Section 1.2(a) or Section 1.10(b), as the case may be. 

1.6 Expenses of Registration. All expenses (other than underwriting discounts and commissions, stock transfer taxes and fees of counsel
to the selling shareholders) incurred in connection with registrations, filings or qualifications pursuant to Section 1.2, Section 1.3 and Section 1.10, including (without limitation) all registration, filing and
qualification fees, printers’ and accounting fees, fees and disbursements of counsel for the Company and the reasonable fees and disbursements of one counsel for the selling Holders (not to exceed $35,000), shall be borne by the Company;
provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Section 1.2(a) or Section 1.10 if the registration request is subsequently
withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered (in which case all participating Holders shall bear such expenses pro rata based upon the number of Registrable Securities that were to be
registered in 

  
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the withdrawn registration); provided, however, that if at the time of such withdrawal, the Holders (i) have learned of a material adverse change in the condition,
business, or prospects of the Company that was not known at the time of their request or could have not been reasonably known given the prior communication or information provided by the Company to the Holders and (ii) have withdrawn the
request with reasonable promptness following disclosure by the Company of such material adverse change, then the Holders shall not be required to pay any of such expenses. 

1.7 Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such
registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 1. 

1.8 Indemnification. In the event any Registrable Securities are included in a registration statement under this Section 1:

 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, any underwriter (as defined in the
Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any losses, claims, damages or liabilities (joint or several) to which they may
become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions
or violations (collectively a “Violation”): (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement, including any preliminary prospectus or final prospectus contained
therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any
violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law; and the Company will pay to
each such Holder, underwriter or controlling person any legal or other expenses reasonably incurred, as incurred, by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided,
however, that the indemnity agreement contained in this Section 1.8(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the
Company (which consent shall not be unreasonably withheld, conditioned or delayed), nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a
Violation which occurs in reliance upon and in conformity with written information furnished expressly for inclusion in a registration statement in connection with such registration by any such Holder, underwriter or controlling person and;
provided further, however, that the foregoing indemnity agreement with respect to any preliminary prospectus shall not inure to the benefit of any Holder or underwriter, or any person controlling such Holder or underwriter, from whom
the person asserting any such losses, claims, damages or liabilities purchased shares in the offering, if a copy of the prospectus (as then amended or supplemented) was not sent or given by or on behalf of such Holder or underwriter to such person,
if required by law so to have been delivered by such Holder, at or prior to the written confirmation of the sale of the shares to such person, and if the prospectus (as so amended or supplemented) would have cured the defect giving rise to such
loss, claim, damage or liability. 

  
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 (b) To the extent permitted by law, each selling Holder, severally and not jointly, will
indemnify and hold harmless the Company, each of its directors, each of its officers who has signed the registration statement, each person, if any, who controls the Company within the meaning of the Securities Act, legal counsel and accountants for
the Company, any underwriter, any other Holder selling securities in such registration statement and any controlling person of any such underwriter or other Holder, against any losses, claims, damages or liabilities (joint or several) to which any
of the foregoing persons may become subject, under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any
Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written information furnished by such Holder expressly for use in connection with such registration; and each such
Holder will pay any legal or other expenses reasonably incurred, as incurred, by any person intended to be indemnified pursuant to this Section 1.8(b), in connection with investigating or defending any such loss, claim, damage, liability
or action; provided, however, that the indemnity agreement contained in this Section 1.8(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected
without the consent of the Holder, which consent shall not be unreasonably withheld, conditioned or delayed, provided that in no event shall any indemnity under this Section 1.8(b) plus any contribution under this Section 1.8
exceed the net proceeds from the offering received by such Holder. 
 (c) Promptly after receipt by an indemnified party under this
Section 1.8 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 1.8,
deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party (together with all other indemnified parties which may be represented without conflict by
one counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate
due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the
commencement of any such action, if prejudicial to its ability to defend such action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 1.8, but the omission to so deliver written notice
to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Section 1.8. 

(d) If the indemnification provided for in this Section 1.8 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, liability, claim, damage or expense referred to therein, then the indemnifying party, in lieu of indemnifying such indemnified party hereunder, shall contribute to the amount paid or payable by such
indemnified party as a result of such loss, liability, claim, damage or expense in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with
the statements or omissions that 

  
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resulted in such loss, liability, claim, damage or expense as well as any other relevant equitable considerations; provided, that, in no event shall any contribution under this
Section 1.8(d) when combined with any payment made pursuant to Section 1.8(b) hereunder by a Holder exceed the net proceeds from the offering received by such Holder. The relative fault of the indemnifying party and of the
indemnified party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the
indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. 

(e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting
agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

(f) Unless otherwise superseded by an underwriting agreement entered into in connection with the underwritten public offering, the
obligations of the Company and Holders under this Section 1.8 shall survive the completion of any offering of Registrable Securities in a registration statement under this Section 1 and otherwise shall survive the termination
of this Agreement. 
 1.9 Reports Under Exchange Act. With a view to making available to the Holders the benefits of Rule 144
promulgated under the Act, (“Rule 144”) and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company agrees to: 
 (a) make and keep public information available, as those terms are
understood and defined in SEC Rule 144, at all times after ninety (90) days after the effective date of the IPO; 
 (b) file with the
SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

(c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) a written statement by the
Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement filed by the Company), the Securities Act and the Exchange Act
(at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies),
(ii) a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company and (iii) such other information as may be reasonably requested in availing any Holder of
any rule or regulation of the SEC which permits the selling of any such securities without registration or pursuant to such form. 

  
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 1.10 Form S-3 Registration. In case the
Company shall receive from the Initiating Holders, a written request or requests that the Company effect a registration on Form S-3 and any related qualification or compliance with respect to all or a part of
the Registrable Securities owned by such Initiating Holder or Holders, the Company will: 
 (a) promptly give written notice of the proposed
registration, and any related qualification or compliance, to all other Holders; and 
 (b) use reasonable efforts to effect such
registration and all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Initiating Holder’s or Holders’ Registrable Securities as are
specified in such request, together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within fifteen (15) days after receipt of such written
notice from the Company; provided, however, that the Company shall not be obligated to effect any such registration, qualification or compliance, pursuant to this Section 1.10: (i) if Form S-3 is not available for such offering by the Initiating Holders; (ii) if the Initiating Holders propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the
public (net of any underwriters’ discounts or commissions) of less than $2,500,000; (iii) after the Company has effected two (2) registrations pursuant to this Section 1.10 in a twelve (12) month period and
such registrations have been declared or ordered effective; (iv) if the Company shall furnish to the Initiating Holders a certificate signed by the President of the Company stating that in the good faith judgment of the Board, it would
be detrimental to the Company and its stockholders for such Form S-3 registration to be filed at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than ninety (90) days after receipt of the request of the Holder or Holders under this Section 1.10; provided, however, that
the Company shall not utilize this right more than once in any twelve (12) month period; or (v) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent
to service of process in effecting such registration, qualification or compliance or otherwise subject itself to general taxation. Subject to the foregoing, the Company shall file a registration statement covering the Registrable Securities and
other securities so requested to be registered as soon as practicable after receipt of the request or requests of the Holders. Registrations effected pursuant to this Section 1.10 shall not be counted as demands for registration effected
pursuant to Section 1.2. 
 1.11 Assignment of Registration Rights. The rights to cause the Company to register
Registrable Securities pursuant to this Section 1 may be assigned (but only with all related obligations) by (i) a Holder that is a partnership, to any subsidiary, parent, partner, retired partner or affiliated fund of such Holder,
(ii) a Holder that is a limited liability company, to any member or former member of such Holder, (iii) a Holder who is an individual, to such Holder’s family member or trust for the benefit of such Holder or such
Holder’s family member, (iv) a Major Investor to an Affiliate; or (v) a Holder to any other person acquiring at least 500,000 Registrable Securities (as appropriately adjusted for any stock split, dividend, combination
or other recapitalization or like transactions) (or all of such transferring Holder’s shares if less); provided (in all cases) (a) the Company is, within a reasonable time after such transfer, furnished with written notice of
the name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned; (b) such transferee or assignee agrees in writing to be bound by and subject to the terms and
conditions of this Agreement, including without limitation the provisions of Section 2 below; and (c) such assignment shall be effective only if immediately following such transfer the further disposition of such securities
by the transferee or assignee is restricted under the Securities Act. 

  
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 1.12    Termination of Registration Rights. No Holder shall be
entitled to exercise any right provided for in this Section 1 after the earlier to occur of the following: (i) the fifth anniversary of the effective date of the IPO, (ii) the date when all Registrable
Securities held by such Holder can be sold in any ninety (90) day period without registration in compliance with Rule 144 or (iii) upon an Acquisition of the Company by a company subject to and in compliance with the
reporting provisions of the Exchange Act, as amended. 
 1.13    Limitations on Subsequent Registration Rights.
From and after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least 65% of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any
securities of the Company which would allow such holder or prospective holder to include such securities in any registration filed under Section 1.2 hereof, unless under the terms of such agreement, such holder or prospective holder may
include such securities in any such registration only to the extent that the inclusion of his securities will not reduce the amount of the Registrable Securities of the Holders which is included. 

2.    Market Stand-Off Agreement. Each Holder hereby agrees that in
connection with an IPO, upon request of the underwriters managing such IPO, that such Holder shall not sell, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale, any Common Stock (or other securities) of the Company held by such Holder immediately before the effective date of the registration statement for the IPO (other than those included in the registration), for a period
specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed one hundred eighty (180) days following the effective date of the registration statement for the IPO; provided,
however, that all executive officers, directors and holders of one percent (1%) or more of the outstanding capital stock of the Company are subject to similar restrictions. Any release from the lock up restrictions, any time during the
market stand-off period, shall be done pro rata among the Holders of Registrable Securities, so that each Holder of Registrable Securities may sell, transfer or otherwise dispose of an equal percentage of his, her or its shares originally
subject to the lock-up restrictions. Each Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriter which are consistent with the foregoing or which are necessary to give further
effect thereto. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of said one hundred eighty (180) day period. The
underwriters of the Company’s stock are intended third party beneficiaries of this Section 2 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Notwithstanding the
foregoing, (i) any Holder that is an entity shall be permitted to distribute securities of the Company during the market stand-off period to its stockholders, members, former members, partners, former partners or other equity holders, or
to an entity controlling, controlled by or under common control with such Investor, so long as each distributee agrees in writing to be bound by the restrictions set forth herein and (ii) the lock-up restrictions shall not apply to
transactions or announcements, in each case, relating to securities acquired in the IPO or securities acquired in open market or other transactions from and after the IPO or that otherwise do not involve or relate to shares of capital stock of the
Company owned by a Holder prior to the IPO. 

  
 12 

 3. Covenants of the Company. 

3.1 Delivery of Financial Statements. The Company shall deliver to each Significant Investor: 

(a) as soon as practicable, but in any event within ninety (90) days after the end of each fiscal year of the Company (or such other time
that the Board unanimously approves), an income statement for such fiscal year, a balance sheet of the Company and statement of stockholder’s equity as of the end of such fiscal year, and a statement of cash flows for such fiscal year, such year-end financial reports to be in reasonable detail and prepared in accordance with generally accepted accounting principles (“GAAP”), and audited and certified by an independent public accounting
firm selected with the approval of the Board; provided, however, that the audit requirement may be waived by the Board, including the Preferred Director Approval; 

(b) as soon as practicable, but in any event within forty five (45) days after the end of each quarter of each fiscal year of the
Company, an unaudited income statement, an unaudited statement of cash flows for such fiscal quarter and an unaudited balance sheet for such quarter, such quarterly financial reports to be in reasonable detail and prepared in accordance with GAAP
(except that such financial statements may (i) be subject to normal year-end audit adjustments; and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

(c) as soon as practicable after the end of each calendar month, and in any event within thirty (30) days thereafter, an unaudited
income statement, an unaudited statement of cash flows for such month, and an unaudited balance sheet for such month, such monthly financial reports to be in reasonable detail and prepared in accordance with GAAP (except that such financial
statements may (i) be subject to normal year-end audit adjustments; and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

(d) as soon as practicable, but in any event at least thirty (30) days prior to the end of each fiscal year, a budget for the next
fiscal year, including balance sheets, income statements and statements of cash flows, such budget to be in reasonable detail and prepared on a monthly basis; 

(e) as soon as practicable, but in any event at least thirty (30) days prior to the end of each fiscal year, an annual
presentation of a business plan for the next fiscal year; and 
 (f) as soon as practicable, but in any event within forty-five
(45) days after the end of each of the first three (3) quarters of each fiscal year of the Company, a statement showing the number of shares of each class and series of capital stock and securities convertible into or exercisable
for shares of capital stock outstanding at the end of the period, the Common Stock issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable
thereto, and the number of shares of issued stock options and stock options not yet issued but reserved for issuance, if any, all in sufficient detail as to permit the Significant Investors to calculate their respective equity ownership in the
Company; and 

  
 13 

 (g) such other information relating to the financial condition, business, prospects or
corporate affairs of the Company as any Significant Investor may from time to time reasonably request; provided, however that the Company shall not be obligated under this Section 3.1 to provide information
(i) that the Company reasonably determines in good faith to be a trade secret or confidential information (unless covered by an enforceable confidentiality agreement, in a form acceptable to the Company); or (ii) the
disclosure of which would adversely affect the attorney-client privilege between the Company and its counsel. 
 3.2 Matters Requiring
Investor Director Approval. So long as any holders of Preferred Stock are entitled to elect one or more Preferred Directors (as defined in the Restated Certificate), the Company hereby covenants and agrees with the Investors that the Company
shall not, and shall not permit any of its subsidiaries to, without the affirmative vote or consent of the Board, including the Preferred Director Approval: 

(a) except with respect to wholly-owned subsidiaries of the Company, make any loan or advance to, or guarantee the indebtedness of, any person
or entity, or make an equity investment in, or otherwise acquire all or any material portion of, any entity; 
 (b) issue any securities of
any subsidiary of the Company to any person other than the Company; 
 (c) sell, transfer, license, pledge or encumber technology or
intellectual property of the Company or any of its subsidiaries, other than non-exclusive licenses granted in the ordinary course of business approved by the Board, or enter into any agreements, arrangements or understandings that require the
Company or any of its subsidiaries to pay any material royalties or other payments to any person or entity with respect to the technology or intellectual property of the Company or any of its subsidiaries; 

(d) make any investment other than investments in prime commercial paper, money market funds, certificates of deposit in any United States
bank, or obligations issued or guaranteed by the United States of America, in each case having a maturity not in excess of one year (including, for the avoidance of doubt and without limitation, any investments in Auction Rate Securities); 

(e) enter into or be a party to any transaction with any director, officer or executive employee of the Company or any of its subsidiaries or
any “associate” (as defined in Rule 12b-2 promulgated under the Exchange Act) of any such person; or 

(f) hire, fire, or materially change the compensation of the Chief Executive Officer or any employee of the Company or any of its
subsidiaries directly reporting to the Chief Executive Officer of the Company, including approving any option grants to any such person. 

  
 14 

 3.3 Inspection. The Company shall permit each Significant Investor, at such
Significant Investor’s expense, to visit and inspect the Company’s properties, to examine its books of account and records and to discuss the Company’s affairs (including any written correspondence with the U.S. Food and Drug
Administration or any comparable regulatory agency outside of the United States), finances and accounts with its officers, all at such reasonable times as may be convenient to the Company and such Significant Investor; provided,
however, that the Company shall not be obligated pursuant to this Section 3.3 to provide access to any information which it reasonably considers to be a trade secret or similar confidential information. 

3.4 Right of First Offer. 

(a) Subject to the terms and conditions specified in this Section 3.4, the Company hereby grants to each Major Investor the right
of first offer with respect to future sales by the Company of its Shares (as hereinafter defined). A Major Investor shall be entitled to apportion the right of first offer hereby granted it among itself and its partners and Affiliates in such
proportions as it deems appropriate. Each time following the date hereof that the Company proposes to offer any shares of, or securities convertible into or exchangeable or exercisable for any shares of, any class of its capital stock
(“Shares”), the Company shall first make an offering of such Shares to each Major Investor in accordance with the following provisions. The Company shall deliver a notice in accordance with Section 5.6 to the Major
Investors stating (i) its bona fide intention to offer such Shares, (ii) the number of such Shares to be offered, and (iii) the price and terms upon which it proposes to offer such Shares. If any prospective
purchaser has offered to pay for any Shares with property, services or any other non-cash consideration, then the Major Investors shall nevertheless have the right to pay for such Shares with cash in an amount equal to the fair market value of the
non-cash consideration offered by the prospective purchaser, where the fair market value of such non-cash consideration shall be conclusively determined in good faith by the Board. 

(b) By written notification received by the Company, within twenty (20) calendar days after delivery of the notice, the Major Investor
may elect to purchase or obtain, at the price and on the terms specified in the notice, up to that portion of such Shares that equals the proportion that the number of shares of Common Stock issued and held, or issuable upon conversion of the
Preferred Stock then held, by such Major Investor bears to the total number of shares of Common Stock of the Company then outstanding (assuming full conversion of all outstanding convertible securities). The Company shall promptly, in writing,
inform each Major Investor that elects to purchase all the shares available to it (a “Fully-Exercising Investor”) of any other Major Investor’s failure to do likewise. During the ten (10) day period commencing after
such information is given, each Fully-Exercising Investor may elect to purchase that portion of the Shares for which Major Investors were entitled to subscribe but which were not subscribed for that is equal to the proportion that the number of
shares of Common Stock issued and held, or issuable upon conversion of Preferred Stock then held, by such Fully-Exercising Investor bears to the total number of shares of Common Stock issued and held, or issuable upon conversion of the Preferred
Stock then held, by all Fully-Exercising Investors who wish to purchase some of the unsubscribed shares. 
 (c) If all Shares that Major
Investors are entitled to obtain pursuant to Section 3.4(b) are not elected to be obtained as provided in Section 3.4(b) hereof, the Company may, during the ninety (90) day period following the expiration of the period
provided in Section 3.4(b) hereof, offer the remaining unsubscribed portion of such Shares to any person or persons at 

  
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a price not less than, and upon terms no more favorable to the offeree than those specified in the notice. If the Company does not enter into a definitive binding agreement for the sale of the
Shares within such period, or if such agreement is not consummated within sixty (60) days of the execution thereof, the right provided hereunder shall be deemed to be revived and such Shares shall not be offered unless first reoffered to the
Major Investors in accordance herewith. 
 (d) The right of first offer in this Section 3.4 shall not be applicable to the
Exempted Securities (as defined in the Restated Certificate) or sales of Series C Preferred Stock pursuant to the Purchase Agreement. 

(e) Notwithstanding the foregoing, the right of first offer in this Section 3.4 shall not be applicable to with respect to any
Major Investor and any subsequent issuance of securities if, (i) at the time of such subsequent issuance of securities, such Major Investor is not an accredited investor as defined in Rule 501(a) of Regulation D promulgated
under the Securities Act, and (ii) such subsequent issuance of securities is otherwise being offered only to accredited investors as defined in Rule 501(a) of Regulation D promulgated under the Securities Act. 

3.5 Confidential Information and Invention Assignment and Non-Solicitation Agreements. The Company shall cause each employee and
consultant/independent contractor now or hereafter employed or engaged by the Company or any of its subsidiaries (including, without limitation, Hugh Y. Rienhoff, Jr.) to execute and deliver a confidential information and invention assignment
agreement substantially in a form approved by counsel to the Investors and the Board, provided, that such form of confidential information and invention assignment agreement shall include non-solicitation provisions (to apply during the term
of employment/engagement and for at least 6 months thereafter) and non-compete provisions (to apply during the term of employment/engagement) customary in substance and form. In addition, the Company shall not amend, modify, terminate, waive, or
otherwise alter, in whole or in part, any such confidential information and invention assignment agreement without the consent of the Board, including the Preferred Director Approval. 

3.6 Indemnification. The Company shall use commercially reasonable efforts to provide that its Restated Certificate and Bylaws provide
for indemnification of officers and directors of the Company to the maximum extent permitted by law. The Company hereby acknowledges that one or more of the directors nominated to serve on the Board by the Investors (each an “Investor
Director”) may have certain rights to indemnification, advancement of expenses and/or insurance provided by one or more of the Investors and certain of their Affiliates (collectively, the “Investor
Indemnitors”). The Company hereby agrees (a) that it is the indemnitor of first resort (i.e., its obligations to any such Investor Director are primary and any obligation of the Investor Indemnitors to advance
expenses or to provide indemnification for the same expenses or liabilities incurred by such Investor Director are secondary), (b) that it shall be required to advance the full amount of expenses incurred by such Investor Director and shall be
liable for the full amount of all expenses, judgments, penalties, fines and amounts paid in settlement by or on behalf of any such Investor Director to the extent legally permitted and as required by the Restated Certificate or the Bylaws of the
Company (or any agreement between the Company and such Investor Director), without regard to any rights such Investor Director may have against the Investor Indemnitors, and, (c) that it irrevocably waives, relinquishes and releases the
Investor Indemnitors from any and all claims against the Investor Indemnitors for contribution, 

  
 16 

 
subrogation or any other recovery of any kind in respect thereof. The Company further agrees that no advancement or payment by the Investor Indemnitors on behalf of any such Investor
Director with respect to any claim for which such Investor Director has sought indemnification from the Company shall affect the foregoing and the Investor Indemnitors shall have a right of contribution and/or be subrogated to the extent of such
advancement or payment to all of the rights of recovery of such Investor Director against the Company. The Investor Directors and the Investor Indemnitors are intended third-party beneficiaries of this Section 3.6 and shall have the
right, power and authority to enforce the provisions of this Section 3.6 as though they were a party to this Agreement. 
 3.7
Directors’ & Officers’ Liability. The Company shall obtain, from financially sound and reputable insurers, and thereafter maintain a policy or policies of directors’ and officers’ liability insurance in an amount of
coverage not less than $5,000,000 (“D&O Insurance”) on terms and conditions satisfactory to the Board, including the Preferred Director Approval, and shall cause such policy to be maintained until such time as the Board,
including the approval of each Preferred Director, determines that such insurance should be discontinued. 
 3.8 Key-Man Life
Insurance. The Company shall use its reasonable efforts to obtain, from financially sound and reputable insurers, term “key-person” insurance on Hugh Y. Rienhoff, Jr. (the
“Founder”) and maintain such insurance for so long as the Founder is the Chief Executive Officer of the Company, in an amount of at least $1,000,000 and on terms and conditions satisfactory to the Board, and will use commercially
reasonable efforts to cause such policy to be maintained until such time as the Board, including the Preferred Director Approval, determines that such insurance should be discontinued. Such key-person policy shall name the Company as loss payee.

 3.9 Board Matters. The Board shall convene for meetings at least six times per year (in person or by teleconference or
videoconference) unless otherwise approved by the Board, including the Preferred Director Approval. No Board meeting shall be held unless a majority of the then-serving directors are present in person or in attendance by electronic means, including
a majority of the then-serving Preferred Directors, if any. Upon request, the Company shall promptly reimburse in full, each non-employee director of the Company for his or her reasonable and documented
out-of-pocket expenses incurred (a) in the course of pre-approved business conducted on behalf of the Company or (b) in connection with attending meetings of the Board or any committee
thereof, including, without limitation, reasonable travel expenses. 
 3.10 Board Committees. If the Board establishes any committee
thereof, each Preferred Director shall have the right, but not the obligation, to serve as a member of any such committee and to serve as a member of the board of directors or similar governing body of any subsidiary of the Company. Each Preferred
Director shall have the right, but not the obligation, to attend as an observer all meetings of scientific and other advisory boards. 

3.11 Stock Vesting. Unless otherwise approved by the Board, including the Preferred Director Approval, all stock, stock options and
other stock equivalents issued after the date of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting no earlier than as follows: (a) twenty-five percent (25%) of such stock shall vest at
the end of the first year following the earlier of the date of issuance or such person’s services 

  
 17 

 
commencement date with the Company, and (b) seventy-five percent (75%) of such stock shall vest in equal monthly installments over the remaining three (3) years. With
respect to any shares of stock purchased by any such person still subject to vesting, the Company’s repurchase option shall provide that upon such person’s termination of employment or service with the Company, with or without cause, the
Company or its assignee shall have the option to purchase at no more than cost any unvested shares of stock held by such person. Without the prior approval by the Board, including the Preferred Director Approval, the Company shall not amend, modify,
terminate, waive or otherwise alter, in whole or in part, any stock purchase, stock restriction or option agreement with any existing employee or service provider if such amendment would cause it to be inconsistent with this
Section 3.11. In addition, unless otherwise approved by the Board, including the Preferred Director Approval, the Company shall not offer or allow any acceleration of vesting (other than, for the avoidance of doubt, pursuant to the terms
of agreements in effect as of the date of this Agreement). No stock option, restricted stock and similar equity grant issued to officers and consultants shall be transferable until such time as such stock option, restricted stock and similar equity
grant is fully vested. No stock option shall have a maximum term of more than ten (10) years. 
 3.12 Observer Rights.
(a) To the extent that Celgene Corporation or its Affiliates (“Celgene”) do not have a representative on the Board, the Company covenants and agrees that Celgene shall be entitled to designate one observer who shall be
an employee of Celgene; (b) to the extent that Amgen Investments Ltd. or its Affiliates (“Amgen”) do not have a representative on the Board, the Company covenants and agrees that Amgen shall be entitled to designate one
observer who shall be an employee of Amgen; (c) to the extent that MRL Ventures Fund LLC or its Affiliates (“MRL”) do not have a representative on the Board, the Company covenants and agrees that MRL shall be entitled to
designate one observer who shall be an employee of MRL; (d) to the extent that Clarus Lifesciences III, L.P. or its Affiliates (“Clarus”) do not have a representative on the Board, the Company covenants and agrees that
Clarus shall be entitled to designate one observer who shall be an employee of Clarus; (e) to the extent that Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. or their Affiliates (“Frazier”) do not have a
representative on the Board, the Company covenants and agrees that Frazier shall be entitled to designate one observer who shall be an employee of Frazier; (f) to the extent that Omega Fund VI, L.P. or its Affiliates
(“Omega”) do not have a representative on the Board, the Company covenants and agrees that Omega shall be entitled to designate one observer who shall be an employee of Omega; (g) to the extent that HighLight Capital or
its Affiliates (“HighLight”) and Pharmaron do not have a representative on the Board, the Company covenants and agrees that HighLight and Pharmaron shall together be entitled to designate one alternate observer who shall be an
employee of HighLight or Pharmaron; and (h) to the extent that Zone II Healthcare Holdings, LLC or its Affiliates (“Farallon”) do not have a representative on the Board, the Company covenants and agrees that Farallon
shall be entitled to designate one observer who shall be an employee of Farallon (each such observer designated by Celgene, Amgen, MRL, Clarus, Frazier, Omega, HighLight and Pharmaron or Farallon, an “Observer”). Observers may be
present (including by telephone or teleconference) at all meetings of the Board and any committees thereof, including any telephonic meetings, and the Company shall give each Observer notice of all such meetings and copies of all minutes, consents,
and other materials that it provides to the members of the Board or any committee thereof, in the same manner as provided to the members of the Board or such committee, in each case not later than the earlier of (a) the same time such
notice, minutes, consents, or other materials are provided or delivered to the members of the Board or such 

  
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committee and (b) 24 hours prior to the time of such proposed Board or committee meeting; provided, that such Observer agrees to hold in confidence in accordance with
Section 3.13 all information regarding the Company provided to such Observer acting in such capacity; and provided, further, that such Observer may be excluded from any meeting or portion thereof and the Company reserves
the right to withhold any information from such Observer if the Company reasonably determined in good faith that such withholding of information or exclusion is reasonably necessary to preserve the attorney-client privilege, to protect highly
confidential proprietary information, if the Board determines in good faith that there exists, with respect to the subject of such deliberation or of such Board materials, an actual or reasonably likely conflict of interest between such Observer and
the Company. 
 3.13 Confidentiality. Each Investor agrees, severally and not jointly, to use the same degree of care as such
Investor uses to protect its own confidential information for any information obtained pursuant to Section 3.1, Section 3.3 and Section 3.12 hereof which the Company identifies in writing as being proprietary or
confidential and such Investor acknowledges that it will not, unless otherwise required by law, regulation, rule, court order or subpoena or the rules of any national securities exchange, association or marketplace, disclose such information without
the prior written consent of the Company except such information that (a) was in the public domain prior to the time it was furnished to such Investor, (b) is or becomes (other than as a result of a breach of this
Section 3.13 by such Investor) generally available to the public, (c) was in such Investor’s possession or known by such Investor prior to receipt from the Company, (d) is or has been made known or disclosed
to such Investor by a third party without a breach of any obligation of confidentiality such third party may have to the Company, or (e) was independently developed or conceived by such Investor without any use of the Company’s
confidential information. Notwithstanding the foregoing, an Investor may disclose such proprietary or confidential information (i) to its attorneys, accountants, employees, consultants, and other professionals; (ii) to any
prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees to be bound by the provisions of this Section 3.13; (iii) to any existing or prospective Affiliate, partner, member,
stockholder, or wholly owned subsidiary of such Investor, or any former partner, member or stockholder who retained an economic interest in such Investor (or any employee or representative of any of the foregoing); or (iv) as requested by, or in
such Investor’s or its Affiliates’ ordinary course reporting to or examinations or similar processes by, any governmental authority, regulatory body or agency, stock exchange or self-regulatory organization. The Company understands and
acknowledges that in the regular course of the business of each of Citadel Multi-Strategy Equities Master Fund Ltd. and its Affiliates (“Surveyor”), T. Row Price Associates, Inc. “T. Rowe”) and its Affiliates and
Farallon and its Affiliates, Surveyor and its Affiliates, T. Rowe and its Affiliates and Farallon and its Affiliates will invest in companies that have issued securities that are publicly traded (each, a “Public Company”).
Accordingly, the Company covenants and agrees that it shall not provide any material non-public information about a Public Company to Surveyor, T. Rowe or Farallon or any representative or Observer of Surveyor, T. Rowe or Farallon. In addition, the
Company acknowledges and agrees that in no event shall Surveyor’s, T. Rowe’s or Farallon’s confidentiality and non-use obligations hereunder in any manner be deemed or construed as limiting Surveyor or its representatives’ (or
any of their respective Affiliates), T. Rowe or its representatives’ (or any of their respective Affiliates’) or Farallon’s or its representatives’ (or any of their respective Affiliates’) ability to trade any security of a
Public Company. 

  
 19 

 3.14 Brokers or Finders. Each party hereto hereby represents and warrants to the
other parties hereto that it neither is nor will be obligated for any finder’s fee or commission in connection with the purchase or sale of Preferred Stock or Common Stock by or to such party. Each Investor agrees to indemnify and to hold
harmless the Company and each other Investor from any liability for any commission or compensation in the nature of a finder’s or broker’s fee arising out of any such purchase or sale (and the costs and expenses of defending against such
liability or asserted liability) for which such Investor or any of its officers, employees or representatives is responsible. The Company agrees to indemnify and hold harmless each Investor from any liability for any commission or compensation in
the nature of a finder’s or broker’s fee arising out of any such purchase or sale (and the costs and expenses of defending against such liability or asserted liability) for which the Company or any of its officers, employees or
representatives is responsible. 
 3.15 Maintenance of Corporate Existence. The Company will preserve, renew and keep in full force
and effect, its corporate existence, qualification in requisite jurisdictions and rights and privileges necessary or desirable in the normal conduct of its business. 

3.16 Further Assurances. The Company will cure promptly any defects in the creation and issuance of the Shares pursuant to the Purchase
Agreement and in the execution and delivery of the Purchase Agreement and any of the Ancillary Agreements (as defined in the Purchase Agreement) to which it is a party. The Company, at its expense, will promptly execute and deliver promptly to each
Purchaser (as defined in the Purchase Agreement) upon request all such other further documents, agreement and instruments in compliance with or pursuant to its covenants and agreements in the Purchase Agreement, and will make any recordings, file
any notices and obtain any consents as may be necessary in connection therewith. 
 3.17 Protection of Intellectual Property. The
Company will use its commercially reasonable best efforts to protect its proprietary rights, including, as appropriate, investigating the feasibility of applying for patent protection on its intellectual property or elements thereof and registering
its material trademarks. 
 3.18 Reservation of Common Stock. The Company will, at all times reserve and keep
available, solely for issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

3.19 Defense Production Act. To the extent that the company engages in the design, fabrication, development, testing, production or
manufacture of critical technologies within the meaning of the Defense Production Act of 1950, as amended, including all implementing regulations thereof, whether because of a new categorization of technology by the U.S. government or otherwise, the
Company shall promptly provide notice to Surveyor, Omega and Farallon. 
 3.20 Right to Conduct Activities. The Company hereby agrees
and acknowledges that each Major Investor (together with its Affiliates) is a professional investment organization, and as such reviews the business plans and related proprietary information of many enterprises, some of which may compete directly or
indirectly with the Company’s business (as currently conducted or as currently propose to be conducted). The Company hereby agrees that, to the extent permitted under applicable law, no Major Investor (or its Affiliates) shall be liable to

  
 20 

 
the Company for any claim arising out of, or based upon, (a) the investment by such Major Investor (or its Affiliates) in any entity competitive with the Company, or (b) actions taken
by any partner, officer, employee or other representative of such Major Investor (or its Affiliates) to assist any such competitive company, whether or not such action was taken as a member of the board of directors of such competitive company or
otherwise, and whether or not such action has a detrimental effect on the Company; provided, however, that the foregoing shall not relieve (i) any Investor from liability associated with the unauthorized disclosure by such Investor of
the Company’s confidential information obtained pursuant to this Agreement, or (ii) any director or officer of the Company from any liability associated with his or her fiduciary duties to the Company. 

3.21 FCPA. The Company represents that it shall not (and shall not permit any of its subsidiaries or Affiliates or any of
its or their respective directors, officers, managers, employees, independent contractors, representatives or agents to) promise, authorize or make any payment to, or otherwise contribute any item of value to, directly or indirectly, to any third
party, including any Non-U.S. Official (as such term is defined in the U.S. Foreign Corrupt Practices Act of 1977, as amended (the “FCPA”)), in each case, in violation of the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery
or anti-corruption law. The Company further represents that it shall (and shall cause each of its subsidiaries and affiliates to) cease all of its or their respective activities, as well as remediate any actions taken by the Company, its
subsidiaries or affiliates, or any of their respective directors, officers, managers, employees, independent contractors, representatives or agents in violation of the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or
anti-corruption law. The Company further represents that it shall (and shall cause each of its subsidiaries and affiliates to) maintain systems of internal controls (including, but not limited to, accounting systems, purchasing systems and billing
systems) to ensure compliance with the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or anti-corruption law. Upon request, the Company agrees to provide responsive information and/or certifications concerning its compliance with
applicable anti-corruption laws. The Company shall promptly notify each Investor if the Company becomes aware of any Enforcement Action (as defined in the Purchase Agreement). The Company shall, and shall cause any direct or indirect subsidiary or
entity controlled by it, whether now in existence or formed in the future, to comply with the FCPA. The Company shall use its best efforts to cause any direct or indirect subsidiary, whether now in existence or formed in the future, to comply in all
material respects with all applicable laws. 
 3.22 Successor Indemnification. If the Company or any of its successors or assignees
consolidates with or merges into any other person and is not the continuing or surviving corporation or entity of such consolidation or merger, then to the extent necessary, proper provision shall be made so that the successors and assignees of the
Company assume the obligations of the Company with respect to indemnification of members of the Board as in effect immediately before such transaction, whether such obligations are contained in the Company’s Bylaws, the Restated Certificate, or
elsewhere, as the case may be. 
 3.24 Termination of Covenants. Except as provided herein, the covenants set forth in
this Section 3, except for Sections 3.6, 3.14 and 3.22, shall terminate immediately prior to the earlier to occur of: (a) the IPO or (b) an Acquisition. Notwithstanding the forgoing sentence,
the covenants set forth in Sections 3.1 and 3.3 hereof will terminate immediately prior to the earliest to occur of: (x) the IPO, (y) the time that the Company becomes subject to the reporting provisions of the
Exchange Act, as amended, or (z) an Acquisition by a company subject to the reporting provisions of the Exchange Act. 

  
 21 

 4. Restrictions on Transferability of Securities; Compliance with Securities
Act. 
 4.1 Restrictions on Transferability. The Preferred Stock and the Registrable Securities shall
not be sold, pledged, or otherwise transferred, and the Company shall not recognize and shall issue stop-transfer instructions to its transfer agent with respect to any such sale, pledge, or transfer, except upon the conditions specified in this
Agreement, which conditions are intended to ensure compliance with the provisions of the Securities Act. A transferring holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by
such holder to agree to take and hold such securities subject to the provisions and upon the conditions specified in this Agreement. 
 4.2
Notice of Proposed Transfers. The holder of each certificate representing Restricted Securities by acceptance thereof agrees to comply in all respects with the provisions of this Section 4.2. 

(a) Before any proposed sale, pledge, or transfer of any Restricted Securities, unless there is in effect a registration statement under the
Securities Act covering the proposed transaction, the holder thereof shall give notice to the Company of such holder’s intention to effect such sale, pledge, or transfer. Each such notice shall describe the manner and circumstances of the
proposed sale, pledge, or transfer in sufficient detail and, if reasonably requested by the Company, shall be accompanied at such holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion
shall, be reasonably satisfactory to the Company, addressed to the Company, to the effect that the proposed transaction may be effected without registration under the Securities Act; (ii) a “no action” letter from the SEC to
the effect that the proposed sale, pledge, or transfer of such Restricted Securities without registration will not result in a recommendation by the staff of the SEC that action be taken with respect thereto; or (iii) any other evidence
reasonably satisfactory to counsel to the Company to the effect that the proposed sale, pledge, or transfer of the Restricted Securities may be effected without registration under the Securities Act, whereupon the holder of such Restricted
Securities shall be entitled to sell, pledge, or transfer such Restricted Securities in accordance with the terms of the notice given by the holder to the Company. Each certificate or instrument evidencing the Restricted Securities transferred as
above provided shall bear, except if such transfer is made pursuant to SEC Rule 144, the appropriate restrictive legend set forth in Section 3.6 of the Purchase Agreement, except that such certificate shall not bear such
restrictive legend if, in the opinion of counsel for such holder and the Company, such legend is not required in order to establish compliance with any provisions of the Securities Act. 

(b) Notwithstanding the provisions of subsection (a) above, no such restriction shall apply to a transfer by a holder that is
(i) a partnership transferring to its partners or former partners in accordance with partnership interests, (ii) a corporation transferring to a wholly-owned subsidiary, Affiliate or a parent corporation that owns all of the
capital stock of the holder, (iii) a limited liability company transferring to its members or former members in accordance with their interest in the limited liability company, (iv) an entity transferring to an Affiliate, or
(v) an individual transferring to the holder’s family member or trust for the benefit of an individual holder; provided that in each case the transferee will agree in writing to be subject to the terms of this Agreement to
the same extent as if he were an original Holder hereunder. 

  
 22 

 5. Miscellaneous. 

5.1 Successors and Assigns. Except as otherwise provided herein, the terms and conditions of this Agreement shall inure to the benefit
of and be binding upon the respective successors and assigns of the parties (including transferees of any shares of Registrable Securities). Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties
hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 

5.2 Governing Law. This Agreement shall be governed by the internal law of the State of New York, without regard to conflict of law
principles that would result in the application of any law other than the law of the State of New York. 
 5.3 Venue. The parties
(a) hereby irrevocably and unconditionally submit to the jurisdiction of the courts of the State of New York located in New York County and the United States District Court for the Southern District of New York for the purpose of any
suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the courts of the State of New York
located in New York County and the United States District Court for the Southern District of New York, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding,
any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of
the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court. 
 WAIVER OF JURY
TRIAL: EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR THE SUBJECT MATTER HEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES
THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT MATTER OF THE TRANSACTIONS CONTEMPLATED HEREUNDER, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND
STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH
ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 

5.4 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument. Counterparts may be delivered via electronic mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other
transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. 

  
 23 

 5.5 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement. 
 5.6 Notices. 

(a) Notices. All notices and other communications required or permitted hereunder shall be in writing and shall be deemed effectively
given: (i) upon personal delivery to the party to be notified; (ii) when sent by e-mail if sent during normal business hours of the recipient, if not, then on the next business day; (iii) five
(5) business days after having been sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) business day after deposit with a nationally recognized overnight courier,
specifying next day delivery, with written verification of receipt. All notices and other communications to the Company shall be sent to: 

Imago BioSciences, Inc. 
 ###

 ### 
 Attn: Chief Executive
Officer 
 Email: ### 
 with a
copy (which shall not constitute notice) to: 
 Latham & Watkins LLP 

140 Scott Drive 
 Menlo Park,
California 94025 
 Attn: Benjamin A. Potter 

Email: ### 
 All notices and other communications
to the Investors shall be made to their respective e-mail addresses or addresses set forth in Schedule A attached hereto. Notwithstanding the foregoing, the Company and any Investor may modify its e-mail address or address for notices hereunder by providing at least ten (10) calendar days advance written notice of such modification to the other parties in accordance with this
Section 5.6. 
 (b) Consent to Electronic Notice. Each Investor consents to the delivery of any
stockholder notice pursuant to the Delaware General Corporation Law (the “DGCL”), as amended or superseded from time to time, by electronic transmission pursuant to Section 232 of the DGCL (or any successor thereto) at
the electronic mail address set forth below such Investor’s name in Schedule A attached hereto, as updated from time to time in accordance with Section 5.6(a), or as on the books of the Company. To the extent that any notice
given by means of electronic transmission is returned or undeliverable for any reason, the foregoing consent shall be deemed to have been revoked until a new or corrected electronic mail address has been provided, and such attempted electronic
notice shall be ineffective and deemed to not have been given. Each Investor agrees to promptly notify the Company of any change in such Investor’s electronic mail address, and that failure to do so shall not affect the foregoing. 

  
 24 

 5.7 Amendments and Waivers. Any term of this Agreement may be amended and the
observance of any term of this Agreement may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least 65% of the Registrable
Securities then outstanding; provided, however, that if any amendment or waiver operates in a manner that materially and disproportionately discriminates against a Holder in relation to the other Holders, the consent of such Holder
shall also be required for such amendment or waiver; provided, further, however, that the addition of new parties to this Agreement or the proportionate adjustment in rights that would result from adding new parties shall not be
deemed to be amendments which materially and disproportionately discriminate against such Major Investor; provided, further, that (a) any amendment to Section 1.1(x), 3.1 or 3.3, or any
other provision of this Agreement to the extent such provision pertains to Section 1.1(x), 3.1 or 3.3, requires the consent of the holders of at least 65% of the Registrable Securities then outstanding and held by the
Significant Investors, and (b) any amendment to Section 1.1(k), 3.4 or 3.20, or any other provision of this Agreement to the extent such provision pertains to Section 1.1(k), 3.4 or 3.20, requires the
consent of the holders of at least 65% of the Registrable Securities then outstanding and held by the Major Investors; provided, further, that if Section 3.4 is waived with respect to a particular issuance of Shares, and a Major
Investor nevertheless participates in such issuance by separate agreement with the Company (such Major Investor, a “Participating Investor”), then such waiver of Section 3.4 shall only be effective if each other Major
Investor is provided the opportunity to purchase a proportional number of the Shares offered by the Company in such issuance (based on the pro rata purchase right of such Major Investor set forth in Section 3.4, assuming a transaction size
determined based upon the amount purchased by the Participating Investor that invested the largest percentage in such issuance relative to the amount such Participating Investor would have been entitled to purchase pursuant to the calculation of the
pro rata right in Section 3.4 had such provision not been waived). Any amendment effected in accordance with this Section shall be binding upon each Investor and the Company; provided, however, that no consent or approval of any Investor
shall be required to add persons as parties to this Agreement as Investors or to revise Schedule A to include such parties. Any amendment effected in accordance with this Section shall be binding upon each Holder of Registrable Securities and
the Company. 
 5.8 Severability. If any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect,
such provision will be enforced to the maximum extent possible and such invalidity, illegality or unenforceability will not affect any other provision of this Agreement. In such event, the parties shall negotiate, in good faith, a legal, valid and
enforceable substitute provision which most nearly effects the intent of the parties in entering into this Agreement. 
 5.9 Additional
Parties. Persons who become “Purchasers” after the effective date of this Agreement pursuant to and in accordance with the Purchase Agreement (each, an “Additional Party”), upon execution and delivery of counterpart
signature pages to this Agreement, shall become parties hereto, each such Additional Party thereby agreeing to be bound by and subject to the terms of this Agreement as an Investor hereunder. Each such Additional Party shall thereafter shall be
deemed an Investor for all purposes under this Agreement. 

  
 25 

 5.10 Delays or Omissions. No delay or omission to exercise any right, power or remedy
accruing to any party to this Agreement, upon any breach or default of any other party to this Agreement, shall impair any such right, power or remedy of such non-breaching or non-defaulting party nor shall it be construed to be a waiver of any such
breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter
occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, must be in
writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative. 

5.11 Aggregation of Stock. All shares of Registrable Securities held or acquired by Affiliates shall be aggregated together for the
purpose of determining the availability of any rights under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner they deem appropriate. 

5.12 Advice of Counsel. EACH PARTY TO THIS AGREEMENT ACKNOWLEDGES THAT, IN EXECUTING THIS AGREEMENT, SUCH PARTY HAS HAD THE OPPORTUNITY
TO SEEK THE ADVICE OF INDEPENDENT LEGAL COUNSEL, AND HAS READ AND UNDERSTOOD ALL OF THE TERMS AND PROVISIONS OF THIS AGREEMENT. THIS AGREEMENT SHALL NOT BE CONSTRUED AGAINST ANY PARTY BY REASON OF THE DRAFTING OR PREPARATION HEREOF. 

5.13 Entire Agreement. This Agreement (including any Schedules hereto) constitutes the full and entire understanding and agreement
among the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly canceled. Upon the effectiveness of this Agreement, the Prior
Agreement shall be deemed amended and restated and superseded and replaced in its entirety by this Agreement, and shall be of no further force or effect. 

(Signature pages follow) 

  
 26 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	COMPANY:
	
	IMAGO BIOSCIENCES, INC.

 
			
		
	By:	 	/s/ Hugh Y. Rienhoff, Jr

 
			
	Name:	 	Hugh Y. Rienhoff, Jr.
	Title:	 	Chief Executive Officer and President

  

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVSTOR:
	
	AMGEN VENTURES LLC

 
			
		
	By:	 	/s/ David A. Piacquad

 
			
	Name:	 	David A. Piacquad
	Title:	 	SVP, Business Development

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	Celgene Corporation

 
			
		
	By:	 	/s/ Daniel O’Connell

 
			
	Name:	 	Daniel O’Connell
	Title:	 	Authorized Signatory

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	BLACKROCK HEALTH SCIENCES
	OPPORTUNITIES PORTFOLIO, A SERIES OF BLACKROCK FUNDS
	By: BlackRock Advisors, LLC, its Investment Adviser
		
	By:	 	/s/ Hongying Erin Xie
	Name: Hongying Erin Xie
	Title: Managing Director
	
	BLACKROCK HEALTH SCIENCES TRUST
	By: BlackRock Advisors, LLC, its Investment Adviser
		
	By:	 	/s/ Hongying Erin Xie
	Name: Hongying Erin Xie
	Title: Managing Director
	
	BLACKROCK HEALTH SCIENCES TRUST II
	By: BlackRock Advisors, LLC, its Investment Adviser
		
	By:	 	/s/ Hongying Erin Xie
	Name: Hongying Erin Xie
	Title: Managing Director
	
	BLACKROCK HEALTH SCIENCES MASTER UNIT TRUST
	By: BlackRock Advisors, LLC, its Investment Adviser
		
	By:	 	/s/ Hongying Erin Xie
	Name: Hongying Erin Xie
	Title: Managing Director

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	CLARUS LIFESCIENCES III, L.P.
	By: Clarus Ventures III GP, L.P., its General Partner
	By: Blackstone Clarus III L.L.C., its General Partner
	By: Blackstone Holdings II L.P., its managing member
	By: Blackstone Holdings I/II GP Inc., its general partner
		
	By:	 	/s/ Robert W. Liptak
	Name: Robert W. Liptak
	Title: Senior Managing Director

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	GREENSPRING EARLY STAGE I, L.P.
		
	By:	 	/s/ Eric Thompson
	Name: Eric Thompson
	Title: COO
	
	GREENSPRING EARLY STAGE I-G, L.P.
		
	By:	 	/s/ Eric Thompson
	Name: Eric Thompson
	Title: COO

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	INSTAR LTD
		
	By:	 	/s/ Fares Zahir
	Name: FARES ZAHIR
	Title: DIRECTOR

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	IRVING INVESTORS PRIVATES OSC IIXX, LLC
		
	 By:
	 	 /s/ Jeremy Abelson

	 Name: Jeremy Abelson

	 Title: Manager

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	IRVING INVESTORS KCM, LLC
	
	By: Kingdon Capital Management, LLC, an agent
		 	and investment advisor
		
	By:	 	/s/ William Walsh
	Name: William Walsh
	Title: CFO

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	KINGDON HEALTHCARE PRIVATE EQUITY, LLC
	
	By: Kingdon Capital Management, LLC, an agent
		 	and investment advisor
		
	By:	 	/s/ William Walsh
	Name: William Walsh
	Title: CFO

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	MERCK SHARP & DOHME CORP.
		
	By:	 	/s/ Kelly Grez
	Name: Kelly Grez
	Title: Secretary

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	MRL VENTURES FUND LLC
		
	By:	 	/s/ Peter Dudek
	Name: Peter Dudek
	Title: Partner

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	OMEGA FUND VI, L.P.
	
	 By: Omega Fund VI GP, L.P.

        its General Partner

	
	 By: Omega Fund VI GP Manager, Ltd.

        its General Partner

		
	By:	 	/s/ Otello Stampacchia
	Name: Otello Stampacchia
	Title: Director

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	FRAZIER HEALTHCARE VII, L.P.
	By: FHM VII, LP, its general partner
	By: FHM VII, LLC, its general partner
		
	By:	 	/s/ Patrick Heron
	Name: Patrick Heron
	Title: Manager
	
	FRAZIER HEALTHCARE VII-A, L.P.
	By: FHM VII, LP, its general partner
	By: FHM VII, LLC, its general partner
		
	By:	 	/s/ Patrick Heron
	Name: Patrick Heron
	Title: Manager

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	 PHARMARON (HONG KONG)

	 INVESTMENTS LIMITED

		
	 By:
	 	 /s/ LI Shing Chung Gilbere

	 Name: LI Shing Chung Gilbere

	 Title: CFO

	 November 8, 2020

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	 POSEIDON MEDICAL HK LIMITED

		
	 By:
	 	 [Signature Illegible]

	 Name:
	 	
	 Title:
	 	

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	 CITADEL MULTI-STRATEGY EQUITIES

MASTER FUND LTD.

	By: Citadel Advisors LLC, its portfolio manager
		
	By:	 	/s/ Christopher L. Ramsay
	Name: Christopher L. Ramsay
	Title: Authorized Signatory

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	 INVESTOR:

	
	
T. ROWE PRICE NEW HORIZONS FUND, INC.

	 T. ROWE PRICE NEW HORIZONS TRUST

	 T. ROWE PRICE U.S. EQUITIES TRUST

	 MASSMUTUAL SELECT FUNDS—MASSMUTUAL

	
SELECT T. ROWE PRICE SMALL AND MID CAP

	 BLEND FUND

	 Each account, severally and not jointly

	
	 By: T. Rowe Price Associates, Inc., Investment

        Adviser or Subadviser, as
applicable

 
			
		
	 By:
	 	 /s/ Andrew
Baek

 
			
	 Name: Andrew Baek

	 Title: Vice President

	
	 Address:

	 T. Rowe Price Associates, Inc.

100 East Pratt Street

	 Baltimore, MD 21202

	 Attn: Andrew Baek, Vice President

	 Phone: ###-###-#####

	 Email: ###

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	T. ROWE PRICE HEALTH SCIENCES FUND, INC.
	TD MUTUAL FUNDS—TD HEALTH SCIENCES FUND
	T. ROWE PRICE HEALTH SCIENCES PORTFOLIO
	 Each account, severally and not jointly

	
	 By: T. Rowe Price Associates, Inc., Investment

      Adviser or Subadviser, as
applicable

 
			
		
	 By:
	 	 /s/ Andrew
Baek

 
			
	 Name: Andrew Baek

	 Title: Vice President

	
	 Address:

	 T. Rowe Price Associates, Inc.

100 East Pratt Street

	 Baltimore, MD 21202

	 Attn: Andrew Baek, Vice President

	 Phone: ###-###-#####

	 Email: ###

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above
written. 
  

			
	INVESTOR:
	
	 ZONE II HEALTHCARE HOLDINGS, LLC

	
	 By: Farallon Capital Management, L.L.C.,
    its
Manager

		
	 By:
	 	 /s/ Philip Dreyfuss

	 Name: Philip Dreyfuss

	 Title: Authorized Signatory

  
 [Signature Page to
Imago BioSciences, Inc. Amended and Restated Investors’ Rights Agreement] 

 SCHEDULE A 

Schedule of Investors 
  

	
	 Zone II Healthcare Holdings, LLC
 c/o Farallon
Capital Management, L.L.C.
 One Maritime Plaza, Suite 2100
 San
Francisco, CA 94111
 Attn: Philip Dreyfuss
 E-mail: ###; ###

	
	 BlackRock Health Sciences Opportunities Portfolio, a Series of BlackRock Funds

c/o BlackRock Advisors, LLC
 BlackRock Capital Management,
Inc.
 60 State Street, 19th/20th Floor
 Boston MA 02109

Attn: Erin Xie
 Email: ###; ###

	
	 BLACKROCK HEALTH SCIENCES TRUST
 c/o BlackRock
Advisors, LLC
 BlackRock Capital Management, Inc.
 60 State
Street, 19th/20th Floor
 Boston MA 02109
 Attn: Erin Xie

Email: ###; ###

	
	 BLACKROCK HEALTH SCIENCES TRUST II
 c/o
BlackRock Advisors, LLC
 BlackRock Capital Management, Inc.
 60
State Street, 19th/20th Floor
 Boston MA 02109
 Attn: Erin
Xie
 Email: ###; ###

	
	 BLACKROCK HEALTH SCIENCES MASTER UNIT TRUST
 c/o
BlackRock Advisors, LLC
 BlackRock Capital Management, Inc.
 60
State Street, 19th/20th Floor
 Boston MA 02109
 Attn: Erin
Xie
 Email: ###; ###

	
	 T. Rowe Price New Horizons Fund, Inc
 c/o T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President
 Phone:
###-###-####
 Email: ###

	
	 T. Rowe Price New Horizons Trust
 c/o T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President
 Phone:
###-###-####
 Email: ###

	
	 T. Rowe Price U.S. Equities Trust
 c/o T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President
 Phone:
###-###-####
 Email: ###

	
	 MassMutual Select Funds—MassMutual Select T. Rowe Price Small and Mid Cap Blend Fund

c/o T. Rowe Price Associates, Inc.
 100 East Pratt Street

Baltimore, MD 21202
 Attn: Andrew Baek, Vice President

Phone: ###-###-####
 Email: ###

	
	 T. Rowe Price Health Sciences Fund, Inc.
 c/o T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President
 Phone:
###-###-####
 Email: ###

	
	 TD Mutual Funds—TD Health Sciences Fund

c/o T. Rowe Price Associates, Inc.
 100 East Pratt Street

Baltimore, MD 21202
 Attn: Andrew Baek, Vice President

Phone: ###-###-####
 Email: ###

	
	 T. Rowe Price Health Sciences Portfolio
 c/o T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President
 Phone:
###-###-####
 Email: ###

	
	 Citadel Multi-Strategy Equities Master Fund Ltd.

c/o Citadel Advisors LLC
 601 Lexington Avenue

New York, New York 10022
 Attention: ### and ###

###; ###; ###

	
	 Irving Investors Privates OSC XXII, LLC
 205
Detroit St, Ste 400
 Denver, CO
 80206

###

	
	 Irving Investors KCM, LLC
 205 Detroit St, Ste
400
 Denver, CO
 80206

###

	
	 Kingdon Healthcare Private Equity, LLC
 205
Detroit St, Ste 400
 Denver, CO
 80206

###

	
	 Amgen Ventures LLC
 One Amgen Center Drive, M/S 28-5-B
 Thousand Oaks, CA 91320

Email: ###; ###; ###

	
	 Clarus Lifesciences III, L.P.
 101 Main Street,
Suite 1210
 Cambridge, MA 02142

E-mail: ###

	
	 Frazier Healthcare VII, L.P.
 70 Willow Road,
Suite 200
 Menlo Park, CA 94025

E-mail: ###

	
	 Frazier Healthcare VII-A, L.P.

70 Willow Road, Suite 200
 Menlo Park, CA 94025

E-mail: ###

	
	 Greenspring Early Stage I, L.P.
 Painters Mill
Road, Suite 700
 Owings Mills, MD 21117
 E-mail: ###

	
	 Greenspring Early Stage I-G, L.P.

Painters Mill Road, Suite 700
 Owings Mills, MD 21117

E-mail: ###

	
	 Instar Ltd
 c/o Xeraya Capital,

26.03-26.08 G Tower,
 199
Jalan Tun Razak,
 50400 Kuala Lampur, Malaysia
 E-mail: ###

	
	 Merck Sharp & Dohme Corp. 
Attn: Office of Secretary

One Merck Drive
 Post Office Box 10

Whitehouse Station, NJ 08889
 (908)
735-1246
 E-mail: ###

	
	 MRL Ventures Fund LLC 
Attn: Reza Halse, Ph.D., President

320 Bent St.
 Cambridge, MA 02141

E-mail: ###

	
	 Omega Fund VI, L.P.
 Omega Fund Management

185 Dartmouth Street, Suite 502
 Boston, MA 02116

E-mail: ###

	
	 Pharmaron (Hong Kong) Investments Limited
 c/o
Pharmaron Beijing Co., Ltd.,
 6 Tai He Road, BDA,
 Beijing
100176, China
 E-mail: ###

	
	 Poseidon Medical HK Limited
 Registered address:
Unit 3A,12/F, Kaiser Centre, No.
 18 Centre Street, Sai Ying Pun, Hong Kong

Mailing address: Building F659, 10th Floor, No. 659
 Fengyang
Road, Jingan District, Shanghai, China
 Attn: ###
 E-mail: ###EX-10.2.(a)

 Exhibit 10.2(a) 

AMENDED AND RESTATED IMAGO BIOSCIENCES, INC. 

2012 EQUITY INCENTIVE PLAN 

Adopted October 31, 2012 

Amended and Restated November 12, 2020 

1. Purposes of the Plan. The purposes of the Imago BioSciences, Inc. 2012 Equity Incentive Plan are to attract and retain the
best available personnel for positions of substantial responsibility, to provide additional incentive to Employees, Directors, and Consultants, and to promote the success of the Company’s business. Options granted under the Plan may be
Incentive Stock Options or Non-Qualified Stock Options, as determined by the Administrator at the time of grant. Stock Purchase Rights may also be granted under the Plan. 

2. Definitions. As used herein, the following definitions shall apply: 

(a) “Administrator” means the Board or the Committee responsible for conducting the general administration of the Plan, as
applicable, in accordance with Section 4 hereof. 
 (b) “Applicable Laws” means the requirements relating to the
administration of stock option plans under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted, and the applicable laws of any foreign
country or jurisdiction where Options or Stock Purchase Rights are granted under the Plan. 
 (c) “Board” means the Board
of Directors of the Company. 
 (d) “Change in Control” shall mean and include each of the following: 

(i) a dissolution or liquidation of the Company; 

(ii) a merger or consolidation in which the Company is not the surviving corporation (other than a merger or consolidation with a
wholly-owned subsidiary, a reincorporation of the Company in a different jurisdiction, or other transaction in which there is no substantial change in the stockholders of the Company or their relative stock holdings and the Options and Stock
Purchase Rights granted under this Plan are assumed, converted or replaced by the successor or acquiring corporation, which assumption, conversion or replacement will be binding on all Holders); 

(iii) a merger in which the Company is the surviving corporation but after which the stockholders of the Company immediately prior to such
merger (other than any stockholder which merges with the Company in such merger, or which owns or controls another corporation which merges with the Company in such merger) cease to own at least a majority of the combined voting power of the
surviving corporation’s outstanding voting securities immediately after the transaction; or 
 (iv) the sale of all or substantially
all of the assets of the Company. 

 The Administrator shall have full and final authority, which shall be exercised in its sole discretion, to
determine conclusively whether a Change in Control has occurred pursuant to the above definition, and the date of the occurrence of such Change in Control and any incidental matters relating thereto. 

(e) “Code” means the Internal Revenue Code of 1986, as amended, or any successor statute or statutes thereto. Reference to
any particular Code section shall include any successor section. 
 (f) “Committee” means a committee appointed by the
Board in accordance with Section 4 hereof. 
 (g) “Common Stock” means the common stock of the Company. 

(h) “Company” means Imago BioSciences, Inc., a Delaware corporation. 

(i) “Consultant” means any consultant or adviser if: (i) the consultant or adviser renders bona fide services to
the Company or any Parent or Subsidiary of the Company; (ii) the services rendered by the consultant or adviser are not in connection with the offer or sale of securities in a capital-raising transaction and do not directly or indirectly
promote or maintain a market for the Company’s securities; and (iii) the consultant or adviser is a natural person. 
 (j)
“Director” means a member of the Board. 
 (k) “Disability” means total and permanent disability within
the meaning of Section 22(e)(3) of the Code. 
 (l) “Employee” means any person, including an Officer or Director, who
is an employee (as defined in accordance with Section 3401(c) of the Code) of the Company or any Parent or Subsidiary of the Company. A Service Provider shall not cease to be an Employee in the case of (i) any leave of absence approved by
the Company or (ii) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any successor. For purposes of Incentive Stock Options, no such leave may exceed ninety (90) days, unless reemployment
upon expiration of such leave is guaranteed by statute or contract. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient, by itself, to constitute “employment” by the Company. 

(m) “Equity Restructuring” shall mean a non-reciprocal transaction between the
Company and its stockholders, such as a stock dividend, stock split, spin-off, rights offering, or recapitalization through a large, nonrecurring cash dividend, that affects the shares of Common Stock (or
other securities of the Company) or the share price of Common Stock (or other securities) and causes a change in the per share value of the Common Stock underlying outstanding awards granted under the Plan. 

  
 2 

 (n) “Exchange Act” means the Securities Exchange Act of 1934, as amended,
or any successor statute or statutes thereto. Reference to any particular Exchange Act section shall include any successor section. 
 (o)
“Fair Market Value” means, as of any date, the value of a share of Common Stock determined as follows: 
 (i) If the Common
Stock is listed on any established stock exchange or a national market system, its Fair Market Value shall be the closing sales price for a share of such stock (or the closing bid, if no sales were reported) as quoted on such exchange or system for
such date, or if no bids or sales were reported for such date, then the closing sales price (or the closing bid, if no sales were reported) on the trading date immediately prior to such date during which a bid or sale occurred, in each case, as
reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
 (ii) If the Common Stock is
regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for a share of the Common Stock on such date, or if no closing bid and asked
prices were reported for such date, the date immediately prior to such date during which closing bid and asked prices were quoted for such Common Stock, in each case, as reported in The Wall Street Journal or such other source as the
Administrator deems reliable; or 
 (iii) In the absence of an established market for the Common Stock, the Fair Market Value thereof shall
be determined by the Administrator. 
 (p) “Holder” means a person who has been granted or awarded an Option or Stock
Purchase Right or who holds Shares acquired pursuant to the exercise of an Option or Stock Purchase Right. 
 (q) “Incentive Stock
Option” means an Option intended to qualify as an incentive stock option within the meaning of Section 422 of the Code and which is designated as an Incentive Stock Option by the Administrator. 

(r) “Independent Director” means a Director who is not an Employee of the Company. 

(s) “Non-Qualified Stock Option” means an Option (or portion thereof) that is not
designated as an Incentive Stock Option by the Administrator, or which is designated as an Incentive Stock Option by the Administrator but fails to qualify as an incentive stock option within the meaning of Section 422 of the Code. 

(t) “Officer” means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and
the rules and regulations promulgated thereunder. 
 (u) “Option” means a stock option granted pursuant to the Plan. 

  
 3 

 (v) “Option Agreement” means a written agreement between the Company and a
Holder evidencing the terms and conditions of an individual Option grant. The Option Agreement is subject to the terms and conditions of the Plan. 

(w) “Parent” means any corporation (or other entity), whether now or hereafter existing (other than the Company), in an
unbroken chain of corporations (or other entities) ending with the Company if each of the corporations (or other entities) other than the last corporation (or other entity) in the unbroken chain owns stock (or other equity interests) possessing more
than fifty percent (50%) of the total combined voting power of all classes of stock (or other equity interests) in one of the other corporations (or other entities) in such chain. 

(x) “Plan” means the Imago BioSciences, Inc. 2012 Equity Incentive Plan. 

(y) “Public Trading Date” means the first date upon which Common Stock of the Company is listed (or approved for listing)
upon notice of issuance on any securities exchange or designated (or approved for designation) upon notice of issuance as a national market security on an interdealer quotation system. 

(z) “Restricted Stock” means Shares acquired pursuant to the exercise of an unvested Option in accordance with
Section 10(h) below or pursuant to a Stock Purchase Right granted under Section 12 below. 
 (aa) “Restricted Stock
Purchase Agreement” means a written agreement between the Company and a Holder evidencing the terms and conditions of the Holder’s purchase of Restricted Stock pursuant to the exercise of an unvested Option in accordance with
Section 10(h) below or a Stock Purchase Right granted under Section 12 below. 
 (bb) “Rule
16b-3” means that certain Rule 16b-3 under the Exchange Act, as such Rule may be amended from time to time. 

(cc) “Section 16(b)” means Section 16(b) of the Exchange Act, as such Section may be amended from
time to time. 
 (dd) “Securities Act” means the Securities Act of 1933, as amended, or any successor statute or statutes
thereto. Reference to any particular Securities Act section shall include any successor section. 
 (ee) “Service Provider”
means an Employee, Director, or Consultant. 
 (ff) “Share” means a share of Common Stock, as adjusted in accordance with
Section 13 below. 
 (gg) “Stock Purchase Right” means a right to purchase Common Stock pursuant to Section 12
below. 
 (hh) “Subsidiary” means any corporation (or other entity), whether now or hereafter existing (other than the
Company), in an unbroken chain of corporations (or other entities) beginning with the Company if each of the corporations (or other entities) other than the last corporation (or other entity) in the unbroken chain owns stock possessing more than
fifty percent (50%) of the total combined voting power of all classes of stock in one of the other corporations (or other entities) in such chain. 

  
 4 

 3. Stock Subject to the Plan. Subject to the provisions of Section 13
hereof, the shares of stock subject to Options or Stock Purchase Rights shall be Common Stock. Subject to the provisions of Section 13 hereof, the maximum aggregate number of Shares which may be issued upon exercise of such Options or Stock
Purchase Rights is Twenty Nine Million Two Hundred Eighty Thousand Five Hundred Thirty-Five (29,280,535). Shares issued upon exercise of Options or Stock Purchase Rights may be authorized but unissued, or reacquired Common Stock. If an Option or
Stock Purchase Right expires or becomes unexercisable without having been exercised in full, the unpurchased Shares which were subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated). Shares
which are delivered by the Holder or withheld by the Company upon the exercise of an Option or Stock Purchase Right under the Plan, in payment of the exercise price thereof or tax withholding thereon, may again be optioned, granted, or awarded
hereunder, subject to the limitations of this Section 3. If Shares of Restricted Stock are repurchased by the Company at their original purchase price, such Shares shall become available for future grant under the Plan (unless the Plan has
terminated). Notwithstanding the provisions of this Section 3, no Shares may again be optioned, granted, or awarded if such action would cause an Incentive Stock Option to fail to qualify as an Incentive Stock Option under Code
Section 422. 
 4. Administration of the Plan. 

(a) Administrator. Unless and until the Board delegates administration to a Committee as set forth below, the Plan shall be
administered by the Board. The Board may delegate administration of the Plan to a Committee or Committees of one (1) or more members of the Board, and the term “Committee” shall apply to any person or persons to whom such authority
has been delegated. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of
the administrative powers the Committee is authorized to exercise (and references in the Plan to the Board shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the
Plan, as may be adopted from time to time by the Board. Notwithstanding the foregoing, however, unless otherwise determined by the Board, from and after the Public Trading Date, a Committee of the Board shall administer the Plan and the Committee
shall consist solely of two (2) or more Independent Directors each of whom is an “outside director,” within the meaning of Section 162(m) of the Code, a “non-employee director”
within the meaning of Rule 16b-3, and qualifies as “independent” within the meaning of any applicable stock exchange listing requirements. Members of the Committee shall also satisfy any other legal
requirements applicable to membership on the Committee, including requirements under the Sarbanes-Oxley Act of 2002 and other Applicable Laws. Within the scope of such authority, the Board or the Committee may (i) delegate to a committee of one
(1) or more members of the Board who are not Independent Directors the authority to grant awards under the Plan to eligible persons who are either (1) not then “covered employees,” within the meaning of Section 162(m) of the
Code and are not expected to be “covered employees” at the time of recognition of income resulting from such award or (2) not persons with respect to whom the Company wishes to 

  
 5 

 
comply with Section 162(m) of the Code and/or (ii) delegate to a committee of one (1) or more members of the Board who are not
“non-employee directors,” within the meaning of Rule 16b-3, the authority to grant awards under the Plan to eligible persons who are not then subject to
Section 16 of the Exchange Act. The Board may abolish the Committee at any time and revest in the Board the administration of the Plan. Appointment of Committee members shall be effective upon acceptance of appointment. Committee members may
resign at any time by delivering written notice to the Board. Vacancies in the Committee may only be filled by the Board. 
 (b) Powers
of the Administrator. Subject to the provisions of the Plan and the specific duties delegated by the Board to such Committee, and subject to the approval of any relevant authorities, the Administrator shall have the authority in its sole
discretion: 
 (i) to determine the Fair Market Value; 

(ii) to select the Service Providers to whom Options and Stock Purchase Rights may from time to time be granted hereunder; 

(iii) to determine the number of Shares to be covered by each such award granted hereunder; 

(iv) to approve forms of agreement for use under the Plan; 

(v) to determine the terms and conditions of any Option or Stock Purchase Right granted hereunder (such terms and conditions include, but are
not limited to, the exercise price, the time or times when Options or Stock Purchase Rights may vest or be exercised (which may be based on performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any restriction or
limitation regarding any Option or Stock Purchase Right or the Common Stock relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall determine); 

(vi) to determine whether to offer to buyout a previously granted Option as provided in Section 10(i) hereof and to determine the terms
and conditions of such offer and buyout (including whether payment is to be made in cash or Shares); 
 (vii) to prescribe, amend, and
rescind rules and regulations relating to the Plan, including rules and regulations relating to sub-plans established for the purpose of qualifying for preferred tax treatment under foreign tax laws; 

(viii) to allow Holders to satisfy withholding tax obligations by electing to have the Company withhold from the Shares to be issued upon
exercise of an Option or Stock Purchase Right that number of Shares having a Fair Market Value equal to the minimum amount required to be withheld based on the statutory withholding rates for federal and state tax purposes that apply to supplemental
taxable income. The Fair Market Value of the Shares to be withheld shall be determined on the date that the amount of tax to be withheld is to be determined. All elections by Holders to have Shares withheld for this purpose shall be made in such
form and under such conditions as the Administrator may deem necessary or advisable; 

  
 6 

 (ix) to amend the Plan or any Option or Stock Purchase Right granted under the Plan as
provided in Section 15 hereof; and 
 (x) to construe and interpret the terms of the Plan and awards granted pursuant to the Plan and
to exercise such powers and perform such acts as the Administrator deems necessary or desirable to promote the best interests of the Company which are not in conflict with the express written provisions of the Plan. 

(c) Effect of Administrator’s Decision. All decisions, determinations, and interpretations of the Administrator shall be final and
binding on all Holders. 
 5. Eligibility. Non-Qualified Stock Options and Stock
Purchase Rights may be granted to Service Providers. Incentive Stock Options may be granted only to Employees of the Company (or a “parent corporation” or “subsidiary corporation” thereof within the meaning of Code Sections
424(e) or 424(f), respectively). If otherwise eligible, a Service Provider who has been granted an Option or Stock Purchase Right may be granted additional Options or Stock Purchase Rights. 

6. Limitations. 

(a) Designations. Each Option shall be designated by the Administrator in the Option Agreement as either an Incentive Stock Option or a
Non-Qualified Stock Option. However, notwithstanding such designations, to the extent that the aggregate Fair Market Value of Shares subject to a Holder’s Incentive Stock Options and other incentive stock
options granted by the Company (or a “parent corporation” or “subsidiary corporation” thereof within the meaning of Code Sections 424(e) or 424(f), respectively), which become exercisable for the first time during any calendar
year (under all plans of the Company or any such parent or subsidiary) exceeds one hundred thousand dollars ($100,000), such excess Options or other options shall be treated as Non-Qualified Stock Options. If
the Code is amended to provide for a different limitation from that set forth in the preceding sentence, such different limitation shall be deemed incorporated herein effective as of the date and with respect to such Options as required or permitted
by such amendment to the Code. 
 For purposes of this Section 6(a), Incentive Stock Options shall be taken into account in the order
in which they were granted, and the Fair Market Value of the Shares shall be determined as of the time of grant. 
 (b) Employment or
Consulting Relationship at Will. Neither the Plan, any Option, nor any Stock Purchase Right shall confer upon a Holder any right with respect to continuing the Holder’s employment or consulting relationship with the Company, nor shall they
interfere in any way with the Holder’s right or the Company’s right to terminate such employment or consulting relationship at any time, with or without cause. 

  
 7 

 (c) Options or Stock Purchase Rights Granted. No Service Provider shall be granted,
in any calendar year, Options or Stock Purchase Rights to purchase more than Two Million (2,000,000) Shares; provided, however, that the foregoing limitation shall not apply prior to the Public Trading Date, and, following the Public
Trading Date, the foregoing limitation shall not apply until the earliest of: (i) the first material modification of the Plan (including any increase in the number of shares reserved for issuance under the Plan in accordance with Section 3
hereof); (ii) the issuance of all of the shares of Common Stock reserved for issuance under the Plan; (iii) the expiration of the Plan; (iv) the first meeting of stockholders at which Directors of the Company are to be elected that occurs
after the close of the third calendar year following the calendar year in which occurred the first registration of an equity security of the Company under Section 12 of the Exchange Act; or (v) such other date required by
Section 162(m) of the Code and the rules and regulations promulgated thereunder. The foregoing limitation shall be adjusted proportionately in connection with any change in the Company’s capitalization as described in Section 13
hereof. For purposes of this Section 6(c), if an Option is canceled in the same calendar year it was granted (other than in connection with a transaction described in Section 13 hereof), the canceled Option will be counted against the
limit set forth in this Section 6(c). For this purpose, if the exercise price of an Option is reduced, the transaction shall be treated as a cancellation of the Option and the grant of a new Option. 

7. Term of Plan. The Plan shall become effective upon its initial adoption by the Board and shall continue in effect until it is
terminated under Section 15 hereof. No Options or Stock Purchase Rights may be issued under the Plan after the tenth (10th) anniversary of the earlier of (a) the date upon which the Plan is adopted by the Board or (b) the date the
Plan is approved by the stockholders. 
 8. Term of Option. The term of each Option shall be stated in the Option Agreement;
provided, however, that the term shall be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to a Holder who, at the time the Option is granted, owns (or is treated as
owning under Code Section 424) stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company (or a “parent corporation” or “subsidiary corporation” thereof within the meaning of
Code Sections 424(e) or 424(f), respectively), the term of the Option shall be five (5) years from the date of grant or such shorter term as may be provided in the Option Agreement. 

9. Option Exercise Price and Consideration. 

(a) Per Share Exercise Price. Except as provided in Section 13 hereof, the per share exercise price for the Shares to be issued
upon exercise of an Option shall be such price as is determined by the Administrator, but shall be subject to the following: 
 (i) In the
case of an Incentive Stock Option 
 (A) granted to an Employee who, at the time of grant of such Option, owns (or is treated as owning
under Code Section 424) stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company (or a “parent corporation” or “subsidiary corporation” thereof within the meaning of Code
Sections 424(e) or 424(f), respectively), the per Share exercise price shall be no less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant. 

(B) granted to any other Employee, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per
Share on the date of grant. 

  
 8 

 (ii) In the case of a Non-Qualified Stock Option,
the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. 

(iii) Notwithstanding the foregoing, an Option may be granted with a per Share exercise price other than as required above if such Option is
granted as an assumption of or in substitution for another option in connection with a merger or other corporate transaction. 
 (b)
Consideration. The consideration to be paid for the Shares to be issued upon exercise of an Option, including the method of payment, shall be determined by the Administrator (and, in the case of an Incentive Stock Option, shall be determined
at the time of grant). Such consideration may consist of (1) cash; (2) check; (3) with the consent of the Administrator, a full recourse promissory note bearing interest (at no less than such rate as is a market rate of interest and
which then precludes the imputation of interest under the Code), payable upon such terms as may be prescribed by the Administrator, and structured to comply with Applicable Laws; (4) with the consent of the Administrator, other Shares which
have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be exercised; (5) with the consent of the Administrator, surrendered Shares then issuable upon exercise of the
Option having a Fair Market Value on the date of exercise equal to the aggregate exercise price of the Option or exercised portion thereof; (6) with the consent of the Administrator, property of any kind which constitutes good and valuable
consideration; (7) with the consent of the Administrator, delivery of a notice that the Holder has placed a market sell order with a broker with respect to Shares then issuable upon exercise of the Options and that the broker has been directed
to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the Option exercise price, provided, that payment of such proceeds is then made to the Company upon settlement of such sale; or (8) with the
consent of the Administrator, any combination of the foregoing methods of payment. 
 10. Exercise of Option. 

(a) Vesting; Fractional Exercises. Except as provided in Section 13 hereof, Options granted hereunder shall be vested and
exercisable according to the terms hereof at such times and under such conditions as determined by the Administrator and set forth in the Option Agreement. An Option may not be exercised for a fraction of a Share. 

(b) Deliveries upon Exercise. All or a portion of an exercisable Option shall be deemed exercised upon delivery of all of the following
to the Secretary of the Company, his or her office, or such other authorized representative of the Company: 
 (i) A written or electronic
notice complying with the applicable rules established by the Administrator stating that the Option, or a portion thereof, is exercised. The notice shall be signed or transmitted electronically, as applicable, by the Holder or other person then
entitled to exercise the Option or such portion of the Option; 

  
 9 

 (ii) Such representations and documents as the Administrator, in its sole discretion, deems
necessary or advisable to effect compliance with Applicable Laws. The Administrator may, in its sole discretion, also take whatever additional actions it deems appropriate to effect such compliance, including, without limitation, placing legends on
share certificates and issuing stop transfer notices to agents and registrars; 
 (iii) Upon the exercise of all or a portion of an
unvested Option pursuant to Section 10(h) hereof, a Restricted Stock Purchase Agreement in a form determined by the Administrator and signed by the Holder or other person then entitled to exercise the Option or such portion of the Option; and

 (iv) In the event that the Option shall be exercised pursuant to Section 10(f) hereof by any person or persons other than the
Holder, appropriate proof of the right of such person or persons to exercise the Option. 
 (c) Conditions to Delivery of Share
Certificates. The Company shall not be required to issue or deliver any certificate or certificates for Shares purchased upon the exercise of any Option or portion thereof nor shall the Holder thereof be deemed to be a stockholder of the Company
prior to fulfillment of all of the following conditions: 
 (i) The admission of such Shares to listing on all stock exchanges on which such
class of stock is then listed; 
 (ii) The completion of any registration or other qualification of such Shares under any state or federal
law, or under the rulings or regulations of the Securities and Exchange Commission or any other governmental regulatory body which the Administrator shall, in its sole discretion, deem necessary or advisable; 

(iii) The obtaining of any approval or other clearance from any state or federal governmental agency which the Administrator shall, in its
sole discretion, determine to be necessary or advisable; 
 (iv) The lapse of such reasonable period of time following the exercise of the
Option as the Administrator may establish from time to time for reasons of administrative convenience; and 
 (v) The receipt by the
Company of full payment for such Shares, including payment of any applicable withholding tax, which in the sole discretion of the Administrator may be in the form of consideration used by the Holder to pay for such Shares under Section 9(b)
hereof. 
 (d) Termination of Relationship as a Service Provider. If a Holder ceases to be a Service Provider other than by reason of
the Holder’s Disability or death, such Holder may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent that the Option is vested on the date of exercise; provided, however,
that, prior to the Public Trading Date, to the extent required by Applicable Law, such period of time shall not be less than thirty (30) days (but in no event later than the expiration of the term of the Option as set forth in the Option
Agreement). In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for three (3) months following the Holder’s termination. If, after termination, the Holder does not exercise his or her Option
within the time period specified, herein, the Option shall terminate, and the Shares covered by such Option shall again become available for issuance under the Plan. 

  
 10 

 (e) Disability of Holder. If a Holder ceases to be a Service Provider as a result of
the Holder’s Disability, the Holder may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent the Option is vested on the date of exercise; provided, however, that prior to the
Public Trading Date, to the extent required by Applicable Law, such period of time shall not be less than six (6) months (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement). In the absence
of a specified time in the Option Agreement, the Option shall remain exercisable for twelve (12) months following the Holder’s termination. If, after termination, the Holder does not exercise his or her Option within the time specified,
herein, the Option shall terminate, and the Shares covered by such Option shall again become available for issuance under the Plan. 
 (f)
Death of Holder. If a Holder dies while a Service Provider, the Option may be exercised within such period of time as is specified in the Option Agreement; provided, however, that prior to the Public Trading Date, to the
extent required by Applicable Law, such period of time shall not be less than six (6) months (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement), by the Holder’s estate or by a person
who acquires the right to exercise the Option by bequest or inheritance, but only to the extent that the Option is vested on the date of exercise. In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for
twelve (12) months following the Holder’s termination. The Option may be exercised by the executor or administrator of the Holder’s estate or, if none, by the person(s) entitled to exercise the Option under the Holder’s will or
the laws of descent or distribution. If the Option is not so exercised within the time specified, herein, the Option shall terminate, and the Shares covered by such Option shall again become available for issuance under the Plan. 

(g) Regulatory Extension. A Holder’s Option Agreement may provide that if the exercise of the Option following the termination of
the Holder’s status as a Service Provider would be prohibited at any time solely because the issuance of shares would violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the
expiration of the term of the Option set forth in Section 8 hereof or (ii) the expiration of a period of three (3) months after the termination of the Holder’s status as a Service Provider during which the exercise of the Option
would not be in violation of such registration requirements. 
 (h) Early Exercisability. The Administrator may provide in the terms
of a Holder’s Option Agreement that the Holder may, at any time before the Holder’s status as a Service Provider terminates, exercise the Option in whole or in part prior to the full vesting of the Option; provided, however,
that subject to Section 19 hereof, Shares acquired upon exercise of an Option which has not fully vested may be subject to any forfeiture, transfer, or other restrictions as the Administrator may determine in its sole discretion. 

(i) Buyout Provisions. The Administrator may at any time offer to buyout for a payment in cash or Shares, an Option previously granted,
based on such terms and conditions as the Administrator shall establish and communicate to the Holder at the time that such offer is made. 

  
 11 

 11. Non-Transferability of
Options and Stock Purchase Rights. Options and Stock Purchase Rights may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or by the laws of descent or distribution and may be
exercised, during the lifetime of the Holder, only by the Holder. 
 12. Stock Purchase Rights. 

(a) Rights to Purchase. Stock Purchase Rights may be issued either alone, in addition to, or in tandem with Options granted under the
Plan and/or cash awards made outside of the Plan. After the Administrator determines that it will offer Stock Purchase Rights under the Plan, it shall advise the offeree in writing of any terms, conditions, and/or restrictions related to the offer,
including the number of Shares that such person shall be entitled to purchase, the price to be paid, and the time within which such person must accept such offer. The offer shall be accepted by execution of a Restricted Stock Purchase Agreement in
the form determined by the Administrator. 
 (b) Repurchase Right. Unless the Administrator determines otherwise, any Restricted
Stock Purchase Agreement shall grant the Company the right to repurchase Shares acquired upon exercise of a Stock Purchase Right upon the termination of the purchaser’s status as a Service Provider for any reason. Subject to Section 19
hereof, the purchase price for Shares repurchased by the Company pursuant to any such repurchase right and the rate at which any such repurchase right shall lapse shall be determined by the Administrator in its sole discretion, and shall be set
forth in the Restricted Stock Purchase Agreement. 
 (c) Other Provisions. Any Restricted Stock Purchase Agreement shall contain such
other terms, provisions, and conditions not inconsistent with the Plan as may be determined by the Administrator in its sole discretion. 

(d) Rights as a Stockholder. Once the Stock Purchase Right is exercised, the purchaser shall have rights equivalent to those of a
stockholder and shall be a stockholder when his or her purchase is entered upon the stock records of the Company. No adjustment shall be made for a dividend or other right for which the record date is prior to the date the Stock Purchase Right is
exercised, except as provided in Section 13 hereof. 
 13. Adjustments upon Changes in Capitalization, Merger, or Asset
Sale. 
 (a) Adjustments Authorized. In the event that the Administrator determines that, other than with respect to an
Equity Restructuring, any dividend or other distribution (whether in the form of cash, Common Stock, other securities, or other property), reorganization, merger, consolidation, combination, repurchase, liquidation, dissolution, or sale, transfer,
exchange, or other disposition of all or substantially all of the assets of the Company, or exchange of Common Stock or other securities of the Company, issuance of warrants or other rights to purchase Common Stock or other securities of the
Company, or other similar corporate transaction or event, in the Administrator’s sole discretion, affects the Common Stock such that an adjustment is determined by the Administrator to be appropriate in order to prevent dilution or enlargement
of the benefits or potential benefits intended by the Company to be made available under the Plan or with respect to any Option, Stock Purchase Right, or Restricted Stock, then the Administrator shall, in such manner as it may deem equitable, adjust
any or all of: 

  
 12 

 (i) the number and kind of shares of Common Stock (or other securities or property) with
respect to which Options or Stock Purchase Rights may be granted or awarded (including, but not limited to, adjustments of the limitations in Section 3 hereof on the maximum number and kind of shares which may be issued and adjustments of the
maximum number of Shares that may be purchased by any Holder in any calendar year pursuant to Section 6(c) hereof); 
 (ii) the number
and kind of shares of Common Stock (or other securities or property) subject to outstanding Options, Stock Purchase Rights, or Restricted Stock; and 

(iii) the grant or exercise price with respect to any Option or Stock Purchase Right. 

(b) Adjustment Actions Authorized. In the event of any transaction or event described in Section 13(a) hereof, the Administrator,
in its sole discretion, and on such terms and conditions as it deems appropriate, either by the terms of the Option, Stock Purchase Right, or Restricted Stock or by action taken prior to the occurrence of such transaction or event and either
automatically or upon the Holder’s request, is hereby authorized to take any one or more of the following actions whenever the Administrator determines that such action is appropriate in order to prevent dilution or enlargement of the benefits
or potential benefits intended by the Company to be made available under the Plan or with respect to any Option, Stock Purchase Right, or Restricted Stock granted or issued under the Plan or to facilitate such transaction or event: 

(i) To provide for either the purchase of any such Option, Stock Purchase Right, or Restricted Stock for an amount of cash equal to the amount
that could have been obtained upon the exercise of such Option or Stock Purchase Right or realization of the Holder’s rights had such Option, Stock Purchase Right, or Restricted Stock been currently exercisable or payable or fully vested or the
replacement of such Option, Stock Purchase Right, or Restricted Stock with other rights or property selected by the Administrator in its sole discretion; 

(ii) To provide that such Option or Stock Purchase Right shall be exercisable as to all shares covered thereby, notwithstanding anything to
the contrary in the Plan or the provisions of such Option or Stock Purchase Right; 
 (iii) To provide that such Option, Stock Purchase
Right, or Restricted Stock be assumed by the successor or survivor corporation, or a parent or subsidiary thereof, or shall be substituted for by similar options, rights, or awards covering the stock of the successor or survivor corporation, or a
parent or subsidiary thereof, with appropriate adjustments as to the number and kind of shares and prices; 

  
 13 

 (iv) To make adjustments in the number and type of shares of Common Stock (or other
securities or property) subject to outstanding Options and Stock Purchase Rights, and/or in the terms and conditions of (including the grant or exercise price), and the criteria included in, outstanding Options, Stock Purchase Rights, or Restricted
Stock or Options, Stock Purchase Rights, or Restricted Stock which may be granted in the future; and/or 
 (v) To provide that immediately
upon the consummation of such event, such Option or Stock Purchase Right shall not be exercisable and shall terminate; provided, that for a specified period of time prior to such event, such Option or Stock Purchase Right shall be exercisable
as to all Shares covered thereby, and the restrictions imposed under an Option Agreement or Restricted Stock Purchase Agreement upon some or all Shares may be terminated and, in the case of Restricted Stock, some or all shares of such Restricted
Stock may cease to be subject to repurchase, notwithstanding anything to the contrary in the Plan or the provisions of such Option, Stock Purchase Right, or Restricted Stock Purchase Agreement. 

(c) Proportional Adjustments. In connection with the occurrence of any Equity Restructuring, and notwithstanding anything to the
contrary in Section 13(a) and 13(b) hereof: 
 (i) The number and type of securities subject to each outstanding Option or Stock
Purchase Right and the exercise price or grant price thereof, if applicable, will be proportionately adjusted. The adjustments provided under this Section 13(c)(i) shall be nondiscretionary and shall be final and binding on the affected Holder
and the Company. 
 (ii) The Administrator shall make such proportionate adjustments, if any, as the Administrator in its sole discretion
may deem appropriate to reflect such Equity Restructuring with respect to the aggregate number and kind of shares that may be issued under the Plan (including, but not limited to, adjustments of the limitations in Section 3 hereof). 

(d) Change in Control. If the Company undergoes a Change in Control, then any surviving corporation or entity or acquiring corporation
or entity, or affiliate of such corporation or entity, may assume any Options, Stock Purchase Rights, and/or Restricted Stock outstanding under the Plan or may substitute similar stock awards (including an award to acquire the same consideration
paid to the stockholders in the transaction described in this Section 13(d)) for those outstanding under the Plan. In the event any surviving corporation or entity or acquiring corporation or entity in a Change in Control, or affiliate of such
corporation or entity, does not assume such Options, Stock Purchase Rights, or Restricted Stock or does not substitute similar stock awards for those outstanding under the Plan, then with respect to (i) Options, Stock Purchase Rights, and
Restricted Stock held by participants in the Plan whose status as a Service Provider has not terminated prior to such event, the vesting of such Options, Stock Purchase Rights, and Restricted Stock (and, if applicable, the time during which such
awards may be exercised) shall be accelerated and made fully exercisable and all restrictions thereon shall lapse at least ten (10) days prior to the closing of the Change in Control (and the Options or Stock Purchase Rights terminated if not
exercised prior to the closing of such Change in Control) and (ii) any other Options or Stock Purchase Rights outstanding under the Plan, such Options and Stock Purchase Rights shall be terminated if not exercised prior to the closing of the
Change in Control. 

  
 14 

 (e) Further Provisions and Limitations. Subject to Section 3 hereof, the
Administrator may, in its sole discretion, include such further provisions and limitations in any Option, Stock Purchase Right, Restricted Stock Purchase Agreement, or certificate, as it may deem equitable and in the best interests of the Company.

 (f) No Effect or Restrictions. The existence of the Plan, any Option Agreement or Restricted Stock Purchase Agreement, and the
Options or Stock Purchase Rights granted hereunder shall not affect or restrict in any way the right or power of the Company or the stockholders of the Company to make or authorize any adjustment, recapitalization, reorganization, or other change in
the Company’s capital structure or its business, any merger or consolidation of the Company, any issue of stock or of options, warrants, or rights to purchase stock or of bonds, debentures, preferred, or prior preference stocks whose rights are
superior to or affect the Common Stock or the rights thereof or which are convertible into or exchangeable for Common Stock, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of its assets or business, or
any other corporate act or proceeding, whether of a similar character or otherwise. 
 14. Time of Granting Options and Stock Purchase
Rights. The date of grant of an Option or Stock Purchase Right shall be, for all purposes, the date on which the Administrator makes the determination granting such Option or Stock Purchase Right, or such other date as is determined by the
Administrator consistent with applicable legal requirements. Notice of the determination shall be given to each Service Provider to whom an Option or Stock Purchase Right is so granted within a reasonable time after the date of such grant. 

15. Amendment and Termination of the Plan. 

(a) Amendment and Termination. Subject to the requirements of subsection (c), the Board may at any time wholly or partially amend,
alter, suspend, or terminate the Plan. However, without approval of the Company’s stockholders given within twelve (12) months before or after the action by the Board, no action of the Board may, except as provided in Section 13
hereof, increase the limits imposed in Section 3 hereof on the maximum number of Shares which may be issued under the Plan or extend the term of the Plan under Section 7 hereof. 

(b) Stockholder Approval. The Board shall obtain stockholder approval of any Plan amendment to the extent necessary and desirable to
comply with Applicable Laws. 
 (c) Effect of Amendment or Termination. No amendment, alteration, suspension, or termination of the
Plan or any Option or Stock Purchase Right shall impair the rights of any Holder, unless mutually agreed otherwise between the Holder and the Administrator, which agreement must be in writing and signed by the Holder and the Company. Termination of
the Plan shall not affect the Administrator’s ability to exercise the powers granted to it hereunder with respect to Options, Stock Purchase Rights, or Restricted Stock granted or awarded under the Plan prior to the date of such termination.

  
 15 

 16. Stockholder Approval. The Plan will be submitted for the approval of the
Company’s stockholders within twelve (12) months after the date of the Board’s initial adoption of the Plan. Options or Stock Purchase Rights may be granted prior to such stockholder approval, provided, that if such approval
has not been obtained at the end of said twelve-month period, all Options and Stock Purchase Rights previously granted under the Plan shall thereupon be canceled and become null and void and any Shares issued
upon exercise thereof shall immediately, and without further action on the part of the Company, be rescinded. 
 17. Inability to
Obtain Authority. The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder,
shall relieve the Company of any liability in respect of the failure to issue or sell such Shares as to which such requisite authority shall not have been obtained. 

18. Reservation of Shares. The Company, during the term of the Plan, shall at all times reserve and keep available such number
of Shares as shall be sufficient to satisfy the requirements of the Plan. 
 19. Repurchase Provisions. The Administrator in
its sole discretion may provide that the Company may repurchase Shares acquired upon exercise of an Option or Stock Purchase Right upon the occurrence of certain specified events, including, without limitation, a Holder’s termination as a
Service Provider, divorce, bankruptcy, or insolvency; provided, however, that any such repurchase right shall be set forth in the applicable Option Agreement or Restricted Stock Purchase Agreement or in another agreement referred to in
such agreement. 
 20. Rules Particular To Specific Countries. 

(a) Generally. To the extent required by the Company, each Holder agrees that he or she shall enter into an election with the Company
or a Subsidiary (in a form approved by the Company) under which any Tax Liability (as defined below) including, but not limited to, National Insurance Contributions (“NICs”) and any Fringe Benefit Tax (“FBT”), is
transferred to and met by the Plan participant. For purposes of this Section 20, Tax Liability shall mean any and all liability under applicable non-U.S. laws, rules, or regulations, from any income tax,
the Company’s (or a Subsidiary’s) NICs, FBT, or similar liability, and the Service Provider’s NICs, FBT, or similar liability under applicable non-U.S. law that are attributable to: (A) the
grant, vesting, or exercise of, or any other benefit derived by the Plan participant from an Option, Stock Purchase Right, or Restricted Stock; (B) the acquisition by the Plan participant of the Shares on exercise of an Option or the
acquisition by the Plan participant of the Shares pursuant to a Stock Purchase Right; or (C) the disposal of any Shares acquired by the Plan participant pursuant to an Option or a Stock Purchase Right granted under the Plan. 

(b) Addendum. Notwithstanding anything herein to the contrary, the terms and conditions of the Plan with respect to Service Providers
who are tax residents of a particular country other than the United States may be subject to an addendum to the Plan in the form of an Appendix. To the extent that the terms and conditions set forth in an Appendix conflict with any provisions of the
Plan, the provisions of the Appendix shall govern. The adoption of any such Appendix shall be pursuant to Section 15 above. 

  
 16 

 21. Investment Intent. The Company may require a Plan participant, as a
condition of exercising or acquiring stock under any Option or Stock Purchase Right, (i) to give written assurances satisfactory to the Company as to the participant’s knowledge and experience in financial and business matters and/or to
employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the purchaser representative, the
merits and risks of exercising the Option or Stock Purchase Right; and (ii) to give written assurances satisfactory to the Company stating that the participant is acquiring the stock subject to the Option or Stock Purchase Right for the
participant’s own account and not with any present intention of selling or otherwise distributing the stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be inoperative if (A) the issuance of
the shares upon the exercise or acquisition of stock under the applicable Option or Stock Purchase Right has been registered under a then currently effective registration statement under the Securities Act or (B) as to any particular
requirement, a determination is made by counsel for the Company that such requirement need not be met in the circumstances under then applicable securities laws. The Company may, upon advice of counsel to the Company, place legends on stock
certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends restricting the transfer of the stock. 

22. Section 409A. To the extent that the Administrator determines that any Option, Stock Purchase Right, or Restricted Stock
granted or awarded under the Plan is subject to Section 409A of the Code, the agreement evidencing such Option, Stock Purchase Right, or Restricted Stock shall incorporate the terms and conditions required by Section 409A of the Code. To
the extent applicable, the Plan and the agreement evidencing such option, Stock Purchase Right, or Restricted Stock shall be interpreted in accordance with Section 409A of the Code and the Department of Treasury regulations and other
interpretive guidance issued thereunder. Notwithstanding any provision of the Plan to the contrary, in the event that the Administrator determines that any Option, Stock Purchase Right, or Restricted Stock may be subject to Section 409A of the
Code and related Department of Treasury regulations and other interpretive guidance issued thereunder, the Administrator may adopt such amendments to the Plan and the applicable agreement or adopt other policies and procedures (including amendments,
policies, and procedures with retroactive effect), or take any other actions, that the Administrator determines are necessary or appropriate to (a) exempt the Option, Stock Purchase Right, or Restricted Stock from Section 409A of the Code
and/or preserve the intended tax treatment of the benefits provided with respect to the Option, Stock Purchase Right, or Restricted Stock, or (b) comply with the requirements of Section 409A of the Code and related Department of Treasury
regulations and other interpretive guidance thereunder and thereby avoid the application of any penalty taxes under such Section. 
 23.
Governing Law. This Plan shall be governed by and construed in accordance with the laws of the State of Delaware excluding that body of law pertaining to conflicts of law. 

*     *     *     *     * 

  
 17 

 I hereby certify that the foregoing Amendment and Restated Plan was duly adopted by the
Company’s Board effective as of November 12, 2020. 
 I hereby further certify that the foregoing Amendment and Restated Plan was
duly adopted by the Company’s Stockholders effective as of November 12, 2020. 
 IN WITNESS WHEREOF, this Amendment and Restated
Plan is executed as of the date first set forth above. 
  

	
	/s/ Benjamin A. Potter
	Benjamin A. Potter, Secretary

 TABLE OF CONTENTS 
  

							
	 	  	 	  	Page	 
	1.	  	PURPOSES OF THE PLAN	  	 	1	 
	2.	  	DEFINITIONS	  	 	1	 
	3.	  	STOCK SUBJECT TO THE PLAN	  	 	5	 
	4.	  	ADMINISTRATION OF THE PLAN	  	 	5	 
	5.	  	ELIGIBILITY	  	 	7	 
	6.	  	LIMITATIONS.	  	 	7	 
	7.	  	TERM OF PLAN	  	 	8	 
	8.	  	TERM OF OPTION	  	 	8	 
	9.	  	OPTION EXERCISE PRICE AND CONSIDERATION	  	 	8	 
	10.	  	EXERCISE OF OPTION.	  	 	9	 
	11.	  	NON-TRANSFERABILITY OF OPTIONS AND STOCK PURCHASE RIGHTS	  	 	12	 
	12.	  	STOCK PURCHASE RIGHTS	  	 	12	 
	13.	  	ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, MERGER, OR ASSET SALE	  	 	12	 
	14.	  	TIME OF GRANTING OPTIONS AND STOCK PURCHASE RIGHTS	  	 	15	 
	15.	  	AMENDMENT AND TERMINATION OF THE PLAN.	  	 	15	 
	16.	  	STOCKHOLDER APPROVAL	  	 	16	 
	17.	  	INABILITY TO OBTAIN AUTHORITY	  	 	16	 
	18.	  	RESERVATION OF SHARES	  	 	16	 
	19.	  	REPURCHASE PROVISIONS	  	 	16	 
	20.	  	RULES PARTICULAR TO SPECIFIC COUNTRIES.	  	 	16	 
	21.	  	INVESTMENT INTENT	  	 	17	 
	22.	  	SECTION 409A.	  	 	17	 
	23.	  	GOVERNING LAW	  	 	17	 

  
 i 

 IMAGO BIOSCIENCES, INC. 

2012 EQUITY INCENTIVE PLAN

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