Document:

Second Amendment to Letter Agreement

 Exhibit 10.29 
 DAWSON JAMES SECURITIES, INC. 
 925 South Federal
Highway, Suite No. 600 
 Boca Raton, Florida 33432 
 September 28, 2009 
 Mr. Tom Chesterman 
 Senior Vice President and Chief Financial Officer 
 Bionovo, Inc. 
 5858 Horton Street, Suite 400 
 Emeryville, CA 94608 
 Re: Amendment of Engagement Letter 

 Dear Mr. Chesterman, 
 This letter amends the letter agreement between Bionovo, Inc. and Dawson James Securities, Inc. (“DJSI”) dated September 10, 2009, as amended September 23, 2009 (as amended, the
“Engagement Letter”) as follows: 
 The exercise price of the transaction fee warrants is derived by
dividing the price of the Units sold in the Registered Placement by ten because each Unit consists of ten shares of common stock (this amount is then multiplied by 125% to calculate the exercise price). 
 The number of transaction fee warrants issuable to DJSI shall be based on the proceeds from the sale of the Units sold in
the Registered Placement (excluding the over-allotment option). Upon exercise of the warrants included in the Units sold in the Registered Placement, DJSI shall not be issued additional warrants nor shall the Company be obligated to pay DJSI any
additional compensation. 
 The warrants issuable to DJSI shall have a term of five years from the date of
closing the Registered Placement. 
 Except as set forth above, the Engagement Letter shall remain in full force
and effect. If you agree with the above please sign below and return an executed copy of this letter to my attention. 
  

	
	 Very truly yours,

	
	DAWSON JAMES SECURITIES, INC.
	
	 /s/ Joseph E. Balagot

	 Joseph E. Balagot

	 Senior Managing Director

 AGREED AND ACCEPTED: 
  

	
	BIONOVO, INC.
	
	 /s/ Tom Chesterman

	 Tom Chesterman

	 Senior Vice President and Chief Financial OfficerThird Amendment to Letter Agreement

 Exhibit 10.30 
 DAWSON JAMES SECURITIES, INC. 
 925 South Federal
Highway, Suite No. 600 
 Boca Raton, Florida 33432 
 September 29, 2009 
 Mr. Tom Chesterman 
 Senior Vice President and Chief Financial Officer 
 Bionovo, Inc. 
 5858 Horton Street, Suite 400 
 Emeryville, CA 94608 
 Re: Amendment of Engagement Letter 

 Dear Mr. Chesterman, 
 This letter amends the letter agreement between Bionovo, Inc. and Dawson James Securities, Inc. (“DJSI”) dated September 10, 2009, as amended September 23, 2009 and September 28,
2009 (as amended, the “Engagement Letter”) as follows: 
 The reference to “8%” in
Section 8(b)(ii) of the Engagement Letter is hereby replaced with “5%” so that the warrant issuable to DJSI is 5% of the common stock sold in the Registered Placement (excluding the over-allotment option and excluding shares issuable
upon exercise of the warrants included in the Units), rather than 8%. 
 Except as set forth above, the
Engagement Letter shall remain in full force and effect. If you agree with the above please sign below and return an executed copy of this letter to my attention. 
  

	
	 Very truly yours

	
	DAWSON JAMES SECURITIES INC.
	
	 /s/ Joseph E. Balagot

	 Joseph E. Balagot

	 Senior Managing Director

 AGREED AND ACCEPTED: 
  

	
	BIONOVO, INC.
	
	 /s/ Tom Chesterman

	 Tom Chesterman

	 Senior Vice President and Chief Financial OfficerThird Supplemental Indenture Series A

 Exhibit 4.1(a) 
 QUALITY DISTRIBUTION, LLC 
 and 
 QD CAPITAL CORPORATION 
 as Issuers 
 the GUARANTORS named in the Indenture (as defined herein), 
 and 
 THE BANK OF
NEW YORK MELLON TRUST COMPANY, N.A. 
 as Trustee 
  
  
 THIRD SUPPLEMENTAL INDENTURE 
 Dated as of
September 29, 2009 
 to 
 Indenture 
 Dated as of January 28, 2005 
 Senior Floating Rate Notes due 2012, Series A 

 THIS THIRD SUPPLEMENTAL INDENTURE, (this “Supplemental Indenture”), dated
as of September 29, 2009, is by and among QUALITY DISTRIBUTION, LLC, a Delaware corporation (the “Company”), QD CAPITAL CORPORATION, a Delaware corporation (“QD Capital” and together with the Company,
the “Issuers”), the Guarantors, as defined in the Original Indenture (the “Guarantors”) and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (formerly known as The Bank of New York Trust Company, N.A.), as trustee
(the “Trustee”). 
 W I T N E S S E T H 
 WHEREAS, reference is made to that certain indenture, dated as of January 28, 2005, between the Issuers, the Guarantors and the
Trustee, as amended and supplemented by a Supplemental Indenture, dated as of December 18, 2007, and as further amended and supplemented by a Second Supplemental Indenture, dated as of August 27, 2009, between the Company, the Guarantors
and the Trustee (the “Original Indenture” and as further amended and supplemented hereby, the “Indenture”), with respect to the Issuers’ Senior Floating Rate Notes due 2012, Series A (the
“Notes”). 
 WHEREAS, in accordance with Section 9.2 of the Original Indenture, the Issuers, the
Guarantors and the Trustee may amend or supplement the Original Indenture with the written consent of the Holder or Holders of at least a majority in aggregate principal amount of the outstanding Notes or any Guarantee without notice to any other
Securityholders. 
 WHEREAS, the Issuers and the Guarantors desire to amend the Original Indenture in accordance with
Section 9.2 of the Original Indenture and have solicited consents from the Holders of the Notes to certain amendments to the Original Indenture pursuant to a Confidential Offering Memorandum and Consent Solicitation Statement dated
August 28, 2009 (the “Offer”); 
 WHEREAS, the Holders of at least a majority in aggregate principal
amount of outstanding Notes or any Guarantee have consented in writing to the amendments to the Original Indenture contained herein; and 
 WHEREAS, the execution and delivery of this Supplemental Indenture have been duly authorized by the parties hereto, and all other acts necessary to make this Supplemental Indenture a valid and binding
supplement to the Original Indenture effectively amending the Original Indenture as set forth herein have been duly taken. 
 NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Issuers, the Guarantors and the Trustee mutually covenant and agree as
follows: 
 ARTICLE I 
 DEFINITIONS 
 Section 1.1    Deletion of
Definitions and Related References.    Section 1.01 of the Original Indenture is hereby amended to delete in their entirety all terms and their respective definitions for which all references are eliminated in the
Original Indenture as a result of the amendments set forth in Article II of this Supplemental Indenture. 

 ARTICLE II  
 AMENDMENTS 
 Section 2.1    Amendments to the Original Indenture.    The Original Indenture is hereby amended by deleting the following sections and clauses, as applicable, of the Original
Indenture and all references to such sections and clauses in their entirety: 
  

			
	(i)	  	Section 4.2 (Maintenance of Office or Agency)
	(ii)	  	Section 4.3 (Limitation on Restricted Payments)
	(iii)	  	Section 4.4 (Limitation on Incurrence of Additional Indebtedness)
	(iv)	  	Section 4.5 (Corporate Existence)
	(v)	  	Section 4.6 (Payment of Taxes and Other Claims)
	(vi)	  	Section 4.7 (Maintenance of Properties and Insurance)
	(vii)	  	Section 4.8 (Compliance Certificate; Notice of Default)
	(viii)	  	Section 4.9 (Compliance with Laws)
	(ix)	  	Section 4.10 (Reports to Holders)
	(x)	  	Section 4.11 (Waiver of Stay, Extension or Usury Laws)
	(xi)	  	Section 4.12 (Limitations on Transactions with Affiliates)
	(xii)	  	Section 4.13 (Limitations on Dividend and Other Payment Restrictions)
	(xiii)	  	Section 4.14 (Limitation on Issuances of Guarantees by Restricted Subsidiaries)
	(xiv)	  	Section 4.15 (After-Acquired Property)
	(xv)	  	Section 4.16 (Change of Control)
	(xvi)	  	Section 4.17 (Limitation on Asset Sales)
	(xvii)	  	Section 4.18 (Future Guarantors)
	(xviii)	  	Section 5.1 (Merger, Consolidation and Sale of Assets - deleting clauses (a)(ii), (a)(iii), (a)(iv), (c)(iii) and (c)(iv) only)
	(xix)	  	Section 6.1 (Events of Default - deleting clauses (iii), (iv), (v), (vi), (vii) and (viii) only)

 ARTICLE III  
 MISCELLANEOUS PROVISIONS 
 Section 3.1    Indenture.    Except as amended hereby, the Original Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall
remain in full force and effect. This Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder of Notes heretofore or hereafter authenticated and delivered under the Original Indenture shall be bound by the
Indenture as amended hereby. Subject to Sections 9.3 and 11.1 of the Indenture, in the case of conflict between the Original Indenture and this Supplemental Indenture, the provisions of this Supplemental Indenture shall control. This Supplemental
Indenture complies with the Trust Indenture Act of 1939 and the Issuers hereby confirm their duties thereunder (including under Section 314 thereof) with respect to the Indenture. 
  

 3 

 Section 3.2     Amendment to
Notes.    The Notes included certain of the foregoing provisions from the Indenture to be deleted or amended pursuant to Articles I and II hereof. Upon the effective date of this Supplemental Indenture, such provisions
from the Notes shall be deemed deleted or amended as applicable. 
 Section 3.3    Effectiveness
of Amendments.    This Supplemental Indenture shall be effective upon execution hereof by the Issuers, the Guarantors and the Trustee; provided, however, that the amendments to the Original Indenture and the Notes set
forth in Articles I and II and Section 3.2 of this Supplemental Indenture shall not become operative until immediately prior to the acceptance for exchange by the Issuers of the Notes tendered pursuant to the Offer. In the event the Company
notifies (if orally, then confirmed in writing) Global Bondholder Services Corporation, as exchange and information agent under the Offer, that it has withdrawn or terminated the Offer, this Supplemental Indenture shall be terminated and of no force
or effect and the Original Indenture shall not be modified hereby. The Company shall deliver to the Trustee a copy of any such notice given to Global Bondholder Services Corporation regarding the Company’s withdrawal or termination of the
Offer. 
 Section 3.4    Severability.    In case any provision in
this Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 Section 3.5    Capitalized Terms.    Capitalized terms used herein but not
defined shall have the meanings assigned to them in the Original Indenture.  
 Section 3.6    Effect of Headings.    The Article and Section headings used herein are for convenience only and shall not affect the construction of this Supplemental Indenture.

 Section 3.7    Trustee Makes No Representations; Recitals.    The
Trustee makes no representation as to the validity or sufficiency of this Supplemental Indenture. The recitals contained herein shall be taken as the statements of the Issuers and the Guarantors and the Trustee assumes no responsibility for their
correctness. 
 Section 3.8    Certain Duties and Responsibilities of the
Trustee.    In entering into this Supplemental Indenture, the Trustee shall be entitled to the benefit of every provision of the Indenture relating to the conduct or affecting the liability or affording protection to the
Trustee, whether or not elsewhere herein so provided. 
 Section 3.9    Governing
Law.    This Supplemental Indenture will be governed by and construed in accordance with the laws of the State of New York, as applied to contracts made and performed within the State of New York, without regards to
principles of conflicts of law. Each of the parties hereto agrees to submit jurisdiction to the jurisdiction of the courts of the State of New York in any action or proceeding arising out of, or relating to, this Supplemental Indenture.

 Section 3.10    Counterparts.    The parties may sign any
number of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent one and the same agreement. 
  

 4 

 Section 3.11    Successors.    All agreements of the Issuers, the Guarantors and the Trustee in this Supplemental Indenture shall bind their respective successors. 
 Section 3.12    Endorsement and Change of Form of Notes.    Any Notes
authenticated and delivered after the close of business on the date that this Supplemental Indenture becomes effective shall be affixed to, stamped, imprinted or otherwise legended by the Trustee, with a notation as follows: 
 “Effective as of September 29, 2009, the restrictive covenants of the Company and certain of the Events of Default have been eliminated, as
provided in the Third Supplemental Indenture, dated as of September 29, 2009. Reference is hereby made to said Third Supplemental Indenture, copies of which are on file with the Trustee, for a description of the amendments made therein.”

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 5 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be
duly executed as of the date first written above. 
  

							
	QUALITY DISTRIBUTION, LLC
			
	By:	 	 /s/ JONATHAN C. GOLD
	 	
		 	Name:	 	Jonathan C. Gold
		 	Title:	 	Senior Vice President, General Counsel & Corporate Secretary
	
	QD CAPITAL CORPORATION
			
	By:	 	 /s/ JONATHAN C. GOLD
	 	
		 	Name:	 	Jonathan C. Gold
		 	Title:	 	Senior Vice President, General Counsel & Corporate Secretary
	
	QUALITY DISTRIBUTION, INC.
			
	By:	 	 /s/ JONATHAN C. GOLD
	 	
		 	Name:	 	Jonathan C. Gold
		 	Title:	 	Senior Vice President, General Counsel & Corporate Secretary

  

 [THIRD SUPPLEMENTAL INDENTURE
(SERIES A NOTES)] 

							
	
	AMERICAN TRANSINSURANCE GROUP, INC.
	BOASSO AMERICA CORPORATION
	CHEMICAL LEAMAN CORPORATION
	ENVIROPOWER, INC.
	FLEET TRANSPORT COMPANY, INC.
	MEXICO INVESTMENTS, INC.
	POWER PURCHASING, INC.
	QD RISK SERVICES, INC.
	QUALA SYSTEMS, INC.
	QUALITY CARRIERS, INC.
	QSI SERVICES, INC.
	TRANSPLASTICS, INC.
			
	By:	 	 /s/ JONATHAN C. GOLD
	 	
		 	Name:	 	Jonathan C. Gold
		 	Title:	 	Senior Vice President, General Counsel & Corporate Secretary
	
	MTL OF NEVADA
			
	By:	 	 /s/ JAMES RAKITSKY
	 	
		 	Name:	 	James Rakitsky
		 	Title:	 	President, Vice President & Chief Financial Officer

  

 [THIRD SUPPLEMENTAL INDENTURE
(SERIES A NOTES)] 

							
	
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
			
	By:	 	 /s/ CHRISTIE LEPPERT
	 	
		 	Name:	 	Christie Leppert
		 	Title:	 	Senior Associate

  

 [THIRD SUPPLEMENTAL INDENTURE
(SERIES A NOTES)]

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