Document:

EX-10.1

Exhibit 10.1

INDEMNIFICATION AGREEMENT

This Indemnification Agreement, dated as shown on the signature page hereof and effective as
of March 1, 2005, is made by and between PEABODY ENERGY CORPORATION, a Delaware corporation (the
“Corporation”) and GREGORY H. BOYCE (the “Indemnitee”).

RECITALS

A. The Corporation recognizes that competent and experienced persons are increasingly
reluctant to serve or to continue to serve as directors or officers of corporations unless they are
protected by comprehensive liability insurance or indemnification, or both, due to increased
exposure to litigation costs and risks resulting from their service to such corporations, and due
to the fact that the exposure frequently bears no reasonable relationship to the compensation of
such directors and officers;

B. The statutes and judicial decisions regarding the duties of directors and officers are
often difficult to apply, ambiguous, or conflicting, and therefore fail to provide such directors
and officers with adequate, reliable knowledge of legal risks to which they are exposed or
information regarding the proper course of action to take;

C. The Corporation and Indemnitee recognize that plaintiffs often seek damages in such large
amounts and the costs of litigation may be so enormous (whether or not the case is meritorious),
that the defense and/or settlement of such litigation is often beyond the personal resources of
directors and officers;

D. The Corporation believes that it is unfair for its directors and officers to assume the
risk of huge judgments and other expenses which may occur in cases in which the director or officer
received no personal profit and in cases where the director or officer was not culpable;

E. The Corporation, after reasonable investigation, has determined that the liability
insurance coverage presently available to the Corporation may be inadequate in certain
circumstances to cover all possible exposure for which Indemnitee should be protected. The
Corporation believes that the interests of the Corporation and its stockholders would best be
served by a combination of such insurance and the indemnification by the Corporation of the
directors and officers of the Corporation;

F. The Corporation’s Amended and Restated Certificate of Incorporation (the “Certificate of
Incorporation”) and Amended and Restated By-Laws require the Corporation to indemnify its directors
and officers to the fullest extent permitted by the Delaware General Corporation Law (the “DGCL”).
The Certificate of Incorporation expressly provides that the indemnification provisions set forth
therein are not exclusive, and contemplates that contracts may be entered into between the
Corporation and its directors and officers with respect to indemnification;

G. Section 145 of the DGCL (“Section 145”), under which the Corporation is organized, empowers
the Corporation to indemnify its officers, directors, employees and agents by agreement and to
indemnify persons who serve, at the request of the Corporation, as the directors, officers,
employees or agents of other corporations or enterprises, and expressly provides that the
indemnification provided by Section 145 is not exclusive;

H. The Board of Directors has determined that contractual indemnification as set forth herein
is not only reasonable and prudent but also promotes the best interests of the Corporation and its
stockholders;

I. The Corporation desires and has requested Indemnitee to serve or continue to serve as a
director or officer of the Corporation free from undue concern for unwarranted claims for damages
arising out of or related to such services to the Corporation; and

J. Indemnitee is willing to serve, continue to serve or to provide additional service for or
on behalf of the Corporation on the condition that he is furnished the indemnity provided for
herein.

AGREEMENT

NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth below, and
other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged,
the parties hereto, intending to be legally bound, hereby agree as follows:

Section 1. Generally.

To the fullest extent permitted by the laws of the State of Delaware:

(a) The Corporation shall indemnify Indemnitee if Indemnitee was or is a party or is
threatened to be made a party to any threatened, pending or completed action, suit or proceeding,
whether civil, criminal, administrative or investigative, by reason of the fact that Indemnitee is
or was or has agreed to serve at the request of the Corporation as a director, officer, employee or
agent of the Corporation, or while serving as a director or officer of the Corporation, is or was
serving or has agreed to serve at the request of the Corporation as a director, officer, employee
or agent (which, for purposes hereof, shall include a trustee, partner or manager or similar
capacity) of another corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise, or by reason of any action alleged to have been taken or omitted in such capacity.

(b) The indemnification provided by this Section 1 shall be from and against expenses
(including attorneys’ fees), judgments, fines and amounts paid in settlement actually and
reasonably incurred by Indemnitee or on Indemnitee’s behalf in connection with such action, suit or
proceeding and any appeal therefrom, but shall only be provided if Indemnitee acted in good faith
and in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the
Corporation, and, with respect to any criminal action, suit or proceeding, had no reasonable cause
to believe Indemnitee’s conduct was unlawful.

(c) Notwithstanding the foregoing provisions of this Section 1, in the case of any threatened,
pending or completed action or suit by or in the right of the Corporation to procure a judgment in
its favor by reason of the fact that Indemnitee is or was a director, officer, employee or agent of
the Corporation, or while serving as a director or officer of the Corporation, is or was serving or
has agreed to serve at the request of the Corporation as a director, officer, employee or agent of
another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise,
no indemnification shall be made in respect of any claim, issue or matter as to which Indemnitee
shall have been adjudged to be liable to the Corporation unless, and only to the extent that, the
Delaware Court of Chancery or the court in which such action or suit was brought shall determine
upon application that, despite the adjudication of liability but in view of all the circumstances
of the case, Indemnitee is fairly and reasonably entitled to indemnity for such expenses which the
Delaware Court of Chancery or such other court shall deem proper.

(d) The termination of any action, suit or proceeding by judgment, order, settlement,
conviction, or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a
presumption that Indemnitee did not act in good faith and in a manner which Indemnitee reasonably
believed to be in or not opposed to the best interests of the Corporation, and, with respect to any
criminal action or proceeding, had reasonable cause to believe that Indemnitee’s conduct was
unlawful.

Section 2. Successful Defense; Partial Indemnification. To the extent that Indemnitee
has been successful on the merits or otherwise in defense of any action, suit or proceeding
referred to in Section 1 hereof or in defense of any claim, issue or matter therein, Indemnitee
shall be indemnified against expenses (including attorneys’ fees) actually and reasonably incurred
in connection therewith. For purposes of this Agreement and without limiting the foregoing, if
any action, suit or proceeding is disposed of, on the merits or otherwise (including a disposition
without prejudice), without (i) the disposition being adverse to Indemnitee, (ii) an adjudication
that Indemnitee was liable to the Corporation, (iii) a plea of guilty or nolo contendere by
Indemnitee, (iv) an adjudication that Indemnitee did not act in good faith and in a manner
Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation,
and (v) with respect to any criminal proceeding, an adjudication that Indemnitee had reasonable
cause to believe Indemnitee’s conduct was unlawful, Indemnitee shall be considered for the
purposes hereof to have been wholly successful with respect thereto.

If Indemnitee is entitled under any provision of this Agreement to indemnification by the
Corporation for some or a portion of the expenses (including attorneys’ fees), judgments, fines or
amounts paid in settlement actually and reasonably incurred by Indemnitee or on Indemnitee’s
behalf in connection with any action, suit, proceeding or investigation, or in defense of any
claim, issue or matter therein, and any appeal therefrom but not, however, for the total amount
thereof, the Corporation shall nevertheless indemnify Indemnitee for the portion of such expenses
(including attorneys’ fees), judgments, fines or amounts paid in settlement to which Indemnitee is
entitled.

Section 3. Determination That Indemnification Is Proper. Any indemnification
hereunder shall (unless otherwise ordered by a court) be made by the Corporation unless a
determination is made that indemnification of such person is not proper in the circumstances
because he or she has not met the applicable standard of conduct set forth in Section 1(b) hereof.
Any such determination shall be made (i) by a majority vote of the directors who are not parties
to the action, suit or proceeding in question (“disinterested directors”), even if less than a
quorum, (ii) by a majority vote of a committee of disinterested directors designated by majority
vote of disinterested directors, even if less than a quorum, (iii) by a majority vote of a quorum
of the outstanding shares of stock of all classes entitled to vote on the matter, voting as a
single class, which quorum shall consist of stockholders who are not at that time parties to the
action, suit or proceeding in question, (iv) by independent legal counsel, or (v) by a court of
competent jurisdiction.

Section 4. Advance Payment of Expenses; Notification and Defense of Claim.

(a) Expenses (including attorneys’ fees) incurred by Indemnitee in defending a threatened or
pending civil, criminal, administrative or investigative action, suit or proceeding shall be paid
by the Corporation in advance of the final disposition of such action, suit or proceeding within
twenty (20) days after receipt by the Corporation of (i) a statement or statements from Indemnitee
requesting such advance or advances from time to time, and (ii) an undertaking by or on behalf of
Indemnitee to repay such amount or amounts, only if, and to the extent that, it shall ultimately be
determined that Indemnitee is not entitled to be indemnified by the Corporation as authorized by
this Agreement or otherwise. Such undertaking shall be accepted without reference to the financial
ability of Indemnitee to make such repayment. Advances shall be unsecured and interest-free.

(b) Promptly after receipt by Indemnitee of notice of the commencement of any action, suit or
proceeding, Indemnitee shall, if a claim thereof is to be made against the Corporation hereunder,
notify the Corporation of the commencement thereof. The failure to promptly notify the Corporation
of the commencement of the action, suit or proceeding, or Indemnitee’s request for indemnification,
will not relieve the Corporation from any liability that it may have to Indemnitee hereunder,
except to the extent the Corporation is prejudiced in its defense of such action, suit or
proceeding as a result of such failure.

(c) In the event the Corporation shall be obligated to pay the expenses of Indemnitee with
respect to an action, suit or proceeding, as provided in this Agreement, the Corporation, if
appropriate, shall be entitled to assume the defense of such action, suit or proceeding, with
counsel reasonably acceptable to Indemnitee, upon the delivery to Indemnitee of written notice of
its election to do so. After delivery of such notice, approval of such counsel by Indemnitee and
the retention of such counsel by the Corporation, the Corporation will not be liable to Indemnitee
under this Agreement for any fees of counsel subsequently incurred by Indemnitee with respect to
the same action, suit or proceeding, provided that (1) Indemnitee shall have the right to employ
Indemnitee’s own counsel in such action, suit or proceeding at Indemnitee’s expense and (2) if (i)
the employment of counsel by Indemnitee has been previously authorized in writing by the
Corporation, (ii) counsel to the Corporation or Indemnitee shall have reasonably concluded that
there may be a conflict of interest or position, or reasonably believes that a conflict is likely
to arise, on any significant issue between the Corporation and Indemnitee in the conduct of any
such defense or (iii) the Corporation shall not, in fact, have employed counsel to assume the
defense of such action, suit or proceeding, then the fees and expenses of Indemnitee’s counsel
shall be at the expense of the Corporation, except as otherwise expressly provided by this
Agreement. The Corporation shall not be entitled, without the consent of Indemnitee, to assume the
defense of any claim brought by or in the right of the Corporation or as to which counsel for the
Corporation shall have reasonably made the conclusion provided for in clause (ii) above.

(d) Notwithstanding any other provision of this Agreement to the contrary, to the extent that
Indemnitee is, by reason of Indemnitee’s corporate status with respect to the Corporation or any
corporation, partnership, joint venture, trust, employee benefit plan or other enterprise which
Indemnitee is or was serving or has agreed to serve at the request of the Corporation, a witness or
otherwise participates in any action, suit or proceeding at a time when Indemnitee is not a party
in the action, suit or proceeding, the Corporation shall indemnify Indemnitee against all expenses
(including attorneys’ fees) actually and reasonably incurred by Indemnitee or on Indemnitee’s
behalf in connection therewith.

Section 5. Procedure for Indemnification

(a) To obtain indemnification, Indemnitee shall promptly submit to the Corporation a written
request, including therein or therewith such documentation and information as is reasonably
available to Indemnitee and is reasonably necessary to determine whether and to what extent
Indemnitee is entitled to indemnification. The Corporation shall, promptly upon receipt of such a
request for indemnification, advise the Board of Directors in writing that Indemnitee has requested
indemnification.

(b) The Corporation’s determination whether to grant Indemnitee’s indemnification request
shall be made promptly, and in any event within 60 days following receipt of a request for
indemnification pursuant to Section 5(a). The right to indemnification as granted by Section 1 of
this Agreement shall be enforceable by Indemnitee in any court of competent jurisdiction if the
Corporation denies such request, in whole or in part, or fails to respond within such 60-day
period. It shall be a defense to any such action (other than an action brought to enforce a claim
for the advance of costs, charges and expenses under Section 4 hereof where the required
undertaking, if any, has been received by the Corporation) that Indemnitee has not met the standard
of conduct set forth in Section 1 hereof, but the burden of proving such defense by clear and
convincing evidence shall be on the Corporation. Neither the failure of the Corporation (including
its Board of Directors or one of its committees, its independent legal counsel, and its
stockholders) to have made a determination prior to the commencement of such action that
indemnification of Indemnitee is proper in the circumstances because Indemnitee has met the
applicable standard of conduct set forth in Section 1 hereof, nor the fact that there has been an
actual determination by the Corporation (including its Board of Directors or one of its committees,
its independent legal counsel, and its stockholders) that Indemnitee has not met such applicable
standard of conduct, shall be a defense to the action or create a presumption that Indemnitee has
or has not met the applicable standard of conduct. The Indemnitee’s expenses (including attorneys’
fees) incurred in connection with successfully establishing Indemnitee’s right to indemnification,
in whole or in part, in any such proceeding or otherwise shall also be indemnified by the
Corporation.

(c) The Indemnitee shall be presumed to be entitled to indemnification under this Agreement
upon submission of a request for indemnification pursuant to this Section 5, and the Corporation
shall have the burden of proof in overcoming that presumption in reaching a determination contrary
to that presumption. Such presumption shall be used as a basis for a determination of entitlement
to indemnification unless the Corporation overcomes such presumption by clear and convincing
evidence.

Section 6. Insurance and Subrogation.

(a) The Corporation may purchase and maintain insurance on behalf of Indemnitee who is or was
or has agreed to serve at the request of the Corporation as a director or officer of the
Corporation, or is or was serving at the request of the Corporation as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust, employee benefit plan
or other enterprise against any liability asserted against, and incurred by, Indemnitee or on
Indemnitee’s behalf in any such capacity, or arising out of Indemnitee’s status as such, whether or
not the Corporation would have the power to indemnify Indemnitee against such liability under the
provisions of this Agreement. If the Corporation has such insurance in effect at the time the
Corporation receives from Indemnitee any notice of the commencement of a proceeding, the
Corporation shall give prompt notice of the commencement of such proceeding to the insurers in
accordance with the procedures set forth in the policy. The Corporation shall thereafter take all
necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee, all
amounts payable as a result of such proceeding in accordance with the terms of such policy.

(b) In the event of any payment by the Corporation under this Agreement, the Corporation shall
be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee with
respect to any insurance policy, who shall execute all papers required and take all action
necessary to secure such rights, including execution of such documents as are necessary to enable
the Corporation to bring suit to enforce such rights in accordance with the terms of such insurance
policy. The Corporation shall pay or reimburse all expenses actually and reasonably incurred by
Indemnitee in connection with such subrogation.

(c) The Corporation shall not be liable under this Agreement to make any payment of amounts
otherwise indemnifiable hereunder (including, but not limited to, judgments, fines, ERISA excise
taxes or penalties, and amounts paid in settlement) if and to the extent that Indemnitee has
otherwise actually received such payment under this Agreement or any insurance policy, contract,
agreement or otherwise.

Section 7. Certain Definitions. For purposes of this Agreement, the following
definitions shall apply:

(a) The term “action, suit or proceeding” shall be broadly construed and shall include,
without limitation, the investigation, preparation, prosecution, defense, settlement, arbitration
and appeal of, and the giving of testimony in, any threatened, pending or completed claim, action,
suit or proceeding, whether civil, criminal, administrative or investigative.

(b) The term “by reason of the fact that Indemnitee is or was a director, officer, employee or
agent of the Corporation, or while serving as a director or officer of the Corporation, is or was
serving or has agreed to serve at the request of the Corporation as a director, officer, employee
or agent of another corporation, partnership, joint venture, trust, employee benefit plan or other
enterprise” shall be broadly construed and shall include, without limitation, any actual or alleged
act or omission to act.

(c) The term “expenses” shall be broadly and reasonably construed and shall include, without
limitation, all direct and indirect costs of any type or nature whatsoever (including, without
limitation, all attorneys’ fees and related disbursements, appeal bonds, other out-of-pocket costs
and reasonable compensation for time spent by Indemnitee for which Indemnitee is not otherwise
compensated by the Corporation or any third party, provided that the rate of compensation and
estimated time involved is approved by the Board, which approval shall not be unreasonably
withheld), actually and reasonably incurred by Indemnitee in connection with either the
investigation, defense or appeal of a proceeding or establishing or enforcing a right to
indemnification under this Agreement, Section 145 of the General Corporation Law of the State of
Delaware or otherwise.

(d) The term “judgments, fines and amounts paid in settlement” shall be broadly construed and
shall include, without limitation, all direct and indirect payments of any type or nature
whatsoever (including, without limitation, all penalties and amounts required to be forfeited or
reimbursed to the Corporation, as well as any penalties or excise taxes assessed on a person with
respect to an employee benefit plan).

(e) The term “Corporation” shall include, without limitation and in addition to the resulting
corporation, any constituent corporation (including any constituent of a constituent) absorbed in a
consolidation or merger which, if its separate existence had continued, would have had power and
authority to indemnify its directors, officers, and employees or agents, so that any person who is
or was a director, officer, employee or agent of such constituent corporation, or is or was serving
at the request of such constituent corporation as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, shall
stand in the same position under the provisions of this Agreement with respect to the resulting or
surviving corporation as he or she would have with respect to such constituent corporation if its
separate existence had continued.

(f) The term “other enterprises” shall include, without limitation, employee benefit plans.

(g) The term “serving at the request of the Corporation” shall include, without limitation,
any service as a director, officer, employee or agent of the Corporation which imposes duties on,
or involves services by, such director, officer, employee or agent with respect to an employee
benefit plan, its participants or beneficiaries.

(h) A person who acted in good faith and in a manner such person reasonably believed to be in
the interest of the participants and beneficiaries of an employee benefit plan shall be deemed to
have acted in a manner “not opposed to the best interests of the Corporation” as referred to in
this Agreement.

Section 8. Limitation on Indemnification. Notwithstanding any other provision herein
to the contrary, the Corporation shall not be obligated pursuant to this Agreement:

(a) Claims Initiated by Indemnitee. To indemnify or advance expenses to Indemnitee
with respect to an action, suit or proceeding (or part thereof) initiated by Indemnitee, except
with respect to an action, suit or proceeding brought to establish or enforce a right to
indemnification (which shall be governed by the provisions of Section 8(b) of this Agreement),
unless such action, suit or proceeding (or part thereof) was authorized or consented to by the
Board of Directors of the Corporation.

(b) Action for Indemnification. To indemnify Indemnitee for any expenses incurred by
Indemnitee with respect to any action, suit or proceeding instituted by Indemnitee to enforce or
interpret this Agreement, unless Indemnitee is successful in establishing Indemnitee’s right to
indemnification in such action, suit or proceeding, in whole or in part, or unless and to the
extent that the court in such action, suit or proceeding shall determine that, despite Indemnitee’s
failure to establish their right to indemnification, Indemnitee is entitled to indemnity for such
expenses; provided, however, that nothing in this Section 8(b) is intended to limit the
Corporation’s obligation with respect to the advancement of expenses to Indemnitee in connection
with any such action, suit or proceeding instituted by Indemnitee to enforce or interpret this
Agreement, as provided in Section 4 hereof.

(c) Section 16 Violations. To indemnify Indemnitee on account of any proceeding with
respect to which final judgment is rendered against Indemnitee for payment or an accounting of
profits arising from the purchase or sale by Indemnitee of securities in violation of Section 16(b)
of the Securities Exchange Act of 1934, as amended, or any similar successor statute.

(d) Non-compete and Non-disclosure. To indemnify Indemnitee in connection with
proceedings or claims involving the enforcement of non-compete and/or non-disclosure agreements or
the non-compete and/or non-disclosure provisions of employment, consulting or similar agreements
the Indemnitee may be a party to with the Corporation, or any subsidiary of the Corporation or any
other applicable foreign or domestic corporation, partnership, joint venture, trust or other
enterprise, if any.

Section 9. Certain Settlement Provisions. The Corporation shall have no obligation
to indemnify Indemnitee under this Agreement for amounts paid in settlement of any action, suit or
proceeding without the Corporation’s prior written consent, which shall not be unreasonably
withheld. The Corporation shall not settle any action, suit or proceeding in any manner that would
impose any fine or other obligation on Indemnitee without Indemnitee’s prior written consent, which
shall not be unreasonably withheld.

Section 10. Savings Clause. If any provision or provisions of this Agreement shall be
invalidated on any ground by any court of competent jurisdiction, then the Corporation shall
nevertheless indemnify Indemnitee as to costs, charges and expenses (including attorneys’ fees),
judgments, fines and amounts paid in settlement with respect to any action, suit or proceeding,
whether civil, criminal, administrative or investigative, including an action by or in the right of
the Corporation, to the full extent permitted by any applicable portion of this Agreement that
shall not have been invalidated and to the full extent permitted by applicable law.

Section 11. Contribution. In order to provide for just and equitable contribution in
circumstances in which the indemnification provided for herein is held by a court of competent
jurisdiction to be unavailable to Indemnitee in whole or in part, it is agreed that, in such event,
the Corporation shall, to the fullest extent permitted by law, contribute to the payment of
Indemnitee’s costs, charges and expenses (including attorneys’ fees), judgments, fines and amounts
paid in settlement with respect to any action, suit or proceeding, whether civil, criminal,
administrative or investigative, in an amount that is just and equitable in the circumstances,
taking into account, among other things, contributions by other directors and officers of the
Corporation or others pursuant to indemnification agreements or otherwise; provided, that, without
limiting the generality of the foregoing, such contribution shall not be required where such
holding by the court is due to (i) the failure of Indemnitee to meet the standard of conduct set
forth in Section 1 hereof, or (ii) any limitation on indemnification set forth in Section 6(c), 8
or 9 hereof.

Section 12. Form and Delivery of Communications. Any notice, request or other
communication required or permitted to be given to the parties under this Agreement shall be in
writing and either delivered in person or sent by telecopy, telex, telegram, overnight mail or
courier service, or certified or registered mail, return receipt requested, postage prepaid, to
the parties at the following addresses (or at such other addresses for a party as shall be
specified by like notice):

If to the Corporation:

Peabody Energy Corporation

701 Market Street

St. Louis, MO 63101

Attn: Vice President and General Counsel

Facsimile: (314) 342-3419

If to Indemnitee:

Mr. Gregory H. Boyce

[Address]

Section 13. Subsequent Legislation. If the General Corporation Law of Delaware is
amended after adoption of this Agreement to expand further the indemnification permitted to
directors or officers, then the Corporation shall indemnify Indemnitee to the fullest extent
permitted by the General Corporation Law of Delaware, as so amended.

Section 14. Nonexclusivity. The provisions for indemnification and advancement of
expenses set forth in this Agreement shall not be deemed exclusive of any other rights which
Indemnitee may have under any provision of law, the Corporation’s Certificate of Incorporation or
By-Laws, in any court in which a proceeding is brought, the vote of the Corporation’s stockholders
or disinterested directors, other agreements or otherwise, and Indemnitee’s rights hereunder shall
continue after Indemnitee has ceased acting as an agent of the Corporation and shall inure to the
benefit of the heirs, executors and administrators of Indemnitee. However, no amendment or
alteration of the Corporation’s Certificate of Incorporation or By-Laws or any other agreement
shall adversely affect the rights provided to Indemnitee under this Agreement

Section 15. Enforcement. The Corporation shall be precluded from asserting in any
judicial proceeding that the procedures and presumptions of this Agreement are not valid, binding
and enforceable. The Corporation agrees that its execution of this Agreement shall constitute a
stipulation by which it shall be irrevocably bound in any court of competent jurisdiction in which
a proceeding by Indemnitee for enforcement of his rights hereunder shall have been commenced,
continued or appealed, that its obligations set forth in this Agreement are unique and special, and
that failure of the Corporation to comply with the provisions of this Agreement will cause
irreparable and irremediable injury to Indemnitee, for which a remedy at law will be inadequate. As
a result, in addition to any other right or remedy Indemnitee may have at law or in equity with
respect to breach of this Agreement, Indemnitee shall be entitled to injunctive or mandatory relief
directing specific performance by the Corporation of its obligations under this Agreement.

Section 16. Interpretation of Agreement. It is understood that the parties hereto
intend this Agreement to be interpreted and enforced so as to provide indemnification to Indemnitee
to the fullest extent now or hereafter permitted by law.

Section 17. Entire Agreement. This Agreement and the documents expressly referred to
herein constitute the entire agreement between the parties hereto with respect to the matters
covered hereby, and any other prior or contemporaneous oral or written understandings or agreements
with respect to the matters covered hereby are expressly superceded by this Agreement.

Section 18. Modification and Waiver. No supplement, modification or amendment of this
Agreement shall be binding unless executed in writing by both of the parties hereto. No waiver of
any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other
provision hereof (whether or not similar) nor shall such waiver constitute a continuing waiver.

Section 19. Successor and Assigns. All of the terms and provisions of this Agreement
shall be binding upon, shall inure to the benefit of and shall be enforceable by the parties hereto
and their respective successors, assigns, heirs, executors, administrators and legal
representatives. The Corporation shall require and cause any direct or indirect successor (whether
by purchase, merger, consolidation or otherwise) to all or substantially all of the business or
assets of the Corporation, by written agreement in form and substance reasonably satisfactory to
Indemnitee, expressly to assume and agree to perform this Agreement in the same manner and to the
same extent that the Corporation would be required to perform if no such succession had taken
place.

Section 20. Service of Process and Venue. For purposes of any claims or proceedings
to enforce this agreement, the Corporation consents to the jurisdiction and venue of any federal
or state court of competent jurisdiction in the states of Delaware and Missouri, and waives and
agrees not to raise any defense that any such court is an inconvenient forum or any similar claim.

Section 21. Governing Law. This Agreement shall be governed exclusively by and
construed according to the laws of the State of Delaware, as applied to contracts between Delaware
residents entered into and to be performed entirely within Delaware. If a court of competent
jurisdiction shall make a final determination that the provisions of the law of any state other
than Delaware govern indemnification by the Corporation of its officers and directors, then the
indemnification provided under this Agreement shall in all instances be enforceable to the fullest
extent permitted under such law, notwithstanding any provision of this Agreement to the contrary.

Section 22. Employment Rights. Nothing in this Agreement is intended to create in
Indemnitee any right to employment or continued employment.

Section 23. Counterparts. This Agreement may be executed in two or more counterparts,
each of which shall be deemed to be an original and all of which together shall be deemed to be one
and the same instrument, notwithstanding that both parties are not signatories to the original or
same counterpart.

Section 24. Headings. The section and subsection headings contained in this Agreement
are for reference purposes only and shall not affect in any way the meaning or interpretation of
this Agreement.

1

IN WITNESS WHEREOF, this Agreement has been duly executed and delivered on April 8, 2005, to
be effective as of March 1, 2005.

PEABODY ENERGY CORPORATION

By  /s/ SHARON D. FIEHLER

	 	 	 	Sharon D. Fiehler, Executive Vice President –
Human Resources and Administration

INDEMNITEE:

By  /s/ GREGORY H. BOYCE

	 	 	 	Gregory H. Boyce

2EX-10.5

LICENSE AGREEMENT

This LICENSE AGREEMENT (“Agreement”), effective as of April 1, 2005 (the “Effective
Date”), is made and entered into by and between Clearant, Inc., a California corporation with a
principal place of business at 11111 Santa Monica Blvd., Suite 650, Los Angeles, California 90025
(“Licensor”), and TriStar Bioventures International, a Washington corporation with a
principal place of business at 1505 Gilman Blvd. NW, Suite #4A, Issaquah, WA 98027
(“Licensee”).

WHEREAS, Licensor has developed and acquired, and continues to develop and acquire,
technologies related to irradiation and inactivation of pathogenic organisms in products, including
without limitation the application of ionizing radiation under various circumstances, including
without limitation conditions, environments, and the presence of various chemical stabilizers (the
“Clearant Process”);

WHEREAS, in connection with the purposes and goals of this Agreement, Licensor desires and
intends to license certain technology to Licensee, to keep Licensee informed as to such matters as
they impact Licensee’s business and this Agreement, and to otherwise work toward the purposes and
goals reflected in this Agreement;

WHEREAS, in connection with the purposes and goals of this Agreement, Licensee desires and
intends to license certain technology from Licensor, to use best efforts in seeking governmental
approvals and commercializing and fully developing markets for certain products manufactured using
the licensed technology, to keep Licensor informed as to such matters as they impact Licensor’s
business and this Agreement, and to otherwise work toward the purposes and goals reflected in this
Agreement;

NOW, THEREFORE, in consideration of the premises and the mutual covenants herein contained,
the parties hereto agree as follows:

ARTICLE 1 — DEFINITIONS

1.1 The term “Allowed Product(s)” shall mean any material or product set forth in
Schedule 1, the manufacture, use, and/or sale of which is covered by, incorporates, involves, or
derives from, in whole or in part, the Technology.

1.2 The term “Asian Party” shall mean an entity whose primary center of business
operations is physically located within the Territory, or that is a wholly-owned subsidiary of an
entity whose headquarters and primary center of business operations are physically located within
the Territory, or if a person, a person who is both a citizen and a resident of one or more of the
countries in the Territory. Notwithstanding anything else in this Agreement, the term “Asian
Party” shall not include any entity formed in, or person or entity relocated to, the Territory for
the purpose of doing business with Licensee or attempting to qualify as an Asian Party under this
Agreement unless such entity is an Affiliate of Licensee. An Asian Party with an established or
reasonably pending relationship with Licensee that, for reasons unrelated to the relationship with
Licensee, becomes a Non-Asian Party shall nevertheless be deemed solely an Asian Party for purposes
of this Agreement. Notwithstanding anything else in this Agreement, CSL Limited and its
subsidiaries and affiliated entities (including without limitation all companies in the CSL Group)
are deemed to be solely Non-Asian Parties, and not Asian Parties. For purposes of this definition,
“Affiliate of Licensee” shall mean an entity formed in the Territory for the purpose of doing
business with Licensee as an Asian Party solely in the Territory that directly, or indirectly
through one or more intermediaries, controls, or is controlled by, or is under common control with,
Licensee: where “control” means the possession, direct or indirect, of the power to direct or cause
the direction of the management and policies of a person or entity.

1.3 The term “Clearant Know-how” shall mean any and all information and intellectual
property (other than trademarks, service marks, and other designations of source) relating to the
irradiation of products and/or the Clearant Process, including but not limited to the use of
various chemical stabilizers, formulation modifications, specifications, circumstances,
environments, and/or conditions in connection with which or under which the Clearant Process may be
carried out, and/or any improvements thereto.

1.4 An Allowed Product has been “Commercialized” (and “Commercialization” has
occurred) when the Licensee first receives revenue for the Allowed Product. Licensee represents
and warrants that it shall not offer for sale any Allowed Product until the Clearant Process has
been successfully transferred, in a commercially reasonable manner, to Licensee with respect to the
Allowed Product, unless the parties otherwise mutually agree in writing.

1.5 The term “Confidential Information” shall mean (i) Clearant Know-how; (ii)
Technology (other than issued patents); (iii) the studies, and the results and reports thereof,
performed or provided by Licensor and/or Licensee under this Agreement, (iv) any information
exchanged by the parties hereunder that the disclosing party expressly designates as confidential
at or before the time of disclosure; and (v) any financial terms of this Agreement.

1.6 The term “Fair Market Value” shall mean, with respect to Licensee, the greater of
the following:

(a) the amount offered by an independent investor, with verified funds available, willing to
purchase a Controlling Interest in Licensee; and

(b) the fair market value of the business taking into account, as applicable, Licensee as a
going concern, tangible and intangible assets, research and development and expected income stream,
as determined by the independent investment banks in the following process: Licensor shall select
one investment bank having more than twenty full-time employees (“Investment Bank A”) to determine
the fair market value of Licensee. Should Licensee disagree with the fair market value determined
by Investment Bank A, Licensee may select a second investment bank having more than twenty
full-time employees (“Investment Bank B”) to determine the fair market value of Licensee in
consultation with Investment Bank A. If Investment Bank B determines a lower value than, or the
same value as, Investment Bank A, then the value determined by Investment Bank A shall be the fair
market value determined by this process; otherwise, Investment Bank A and Investment Bank B shall
jointly select a third investment bank having more than twenty full-time employees (“Investment
Bank C”) to determine the value of Licensee in consultation with Investment Bank A and Investment
Bank B. The fair market value determined by this process shall be whichever of the values of
Investment Bank A, Investment Bank B, and Investment Bank C falls between the other two, or if two
values are the same, then that value shall be the fair market value determined by this process.

For purposes of this Section 1.6 and Section 6.1, the term “Controlling Interest” means at
least 51% of the voting interest of Licensee if Licensee is private at the time, or at least 38% of
the voting interest of Licensee if Licensee is public at the time.

1.7 The term “Gross Revenues” shall mean all receipts, payments, or consideration of
any kind, whether monetary or otherwise, before any deductions, from any customer of Licensee or
Affiliate and/or any customer of any of Licensee’s or Affiliate’s subsidiaries, distributors,
sublicensees, or joint venturers, resulting or derived from any use of the Clearant Process. For
purposes of this Section 1.7, “use of the Clearant Process” shall mean any act or use of the
Technology, in whole or in part, that would be an infringing or otherwise impermissible act or use
but for the license in Section 3.1 (or any sublicense thereof); any sublicense of any rights in
Section 3.1; and any sale, distribution, or other transfer of any Allowed Product.

1.8 The term “Non-Asian Party” shall mean any person or entity that is not an Asian
Party. A Non-Asian Party with an established or reasonably pending relationship with Licensor
that, for reasons unrelated to the relationship with Licensor, becomes an Asian Party shall
nevertheless be deemed solely a Non-Asian Party for purposes of this Agreement.

1.9 The term “Technology” shall mean the patents and patent applications (including
any divisions, continuations, or continuations-in-part thereof, any patents that may issue from
such patent applications, any reissues, extensions, or reexaminations of such patents, and any
foreign counterparts worldwide of such patents or patent applications) listed on Schedule 2 hereto;
and any and all unpatented inventions (whether patentable or nonpatentable), copyrights, Clearant
Know-how, trade secrets, tangible research property, technical data, and other information and
intellectual property owned by Licensor, or licensed by Licensor from third parties, including
later-developed intellectual property identified in Section 7.1, that is necessary to use or
practice the Clearant Process in connection with the manufacture and/or sale of Allowed Products.
Notwithstanding the foregoing, “Technology” shall not include any claims in continuation-in-part
patent applications (including all divisions and continuations of these continuations-in-part),
patents issuing from continuations-in-part (including reissues, reexaminations, and extensions of
such patents) and/or international counterparts thereof to the extent that such claims are directed
to new matter that is not the subject matter of those patents and patent applications listed in
Schedule 2. Licensor shall be obligated to amend Schedule 2 from time to time to add additional
patents and/or patent applications in which it then has an interest that it determines are
necessary for Licensee to make or sell Allowed Products, provided, however, that patents and/or
patent applications that are not related to the actual inactivation of pathogens as contemplated by
the Technology, as of the date hereof, may not be included. By way of example, but not limitation,
technology dealing with Polymerase Chain Reaction (PCR) testing on treated allografts would be
outside of “related to the actual inactivation of pathogens”.

Any claim of an issued patent or claim of a patent application within that has been (i)
cancelled, except in response to a restriction requirement, (ii) disclaimed by Licensor, or (iii)
determined to be invalid or unenforceable by a court or administrative agency of competent
jurisdiction and such determination is final or is upheld on appeal, or that has expired, shall not
be considered to be within the Technology effective as of the date of such cancellation,
disclaimer, final determination, or expiration. Any such cancellation, disclaimer, final
determination, or expiration shall not terminate or otherwise impair this Agreement.

1.10 The term “Territory” shall mean the geographical area comprising the countries
that are currently (as of the Effective Date) known as: Japan, China, Taiwan, Hong Kong,
Singapore, India, Pakistan, South Korea, North Korea, Laos, Sri Lanka, Myanmar, Cambodia, Vietnam,
Thailand, Philippines, Malaysia, Indonesia, Australia, and New Zealand.

1.11 The term “Total Cost” with respect to a party’s product development with an
entity shall mean all non-reimbursable and non-recoverable costs actually incurred and paid by that
party directly related to Commercializing Allowed Products with that entity, as shown by written
receipts and contemporaneously-kept time records showing work directly relating to Commercializing
Allowed Products with the entity. Total Cost shall not include overhead costs of the party that
would have been incurred by the party even if the party had not Commercialized or attempted to
Commercialize Allowed Products with the entity.

1.12 The term “Trademarks” shall mean, individually and collectively, the marks,
names, logos, and/or graphics set forth in Schedule 3 hereto, and any additional marks, names,
logos, and/or graphics that Licensor may develop and approve in writing for use by Licensee.

1.13 As used throughout this Agreement, the term “sublicense” shall include sublicenses of
sublicenses, and the term “sublicensees” shall include sublicensees of sublicensees.

1.14 As used in Section 12.5, a “Cure” shall mean a reasonable mechanism of correcting sales
of Allowed Products that fail to meet the Quality Standards that is approved by Licensor in its
sole discretion. Such a mechanism may involve Licensee stopping application of Clearant Technology
on the offending Allowed Product(s) and any related Allowed Product(s), terminating any agreements
with third parties at least as to the offending Allowed Product(s) and any related Allowed
Product(s), and recalling previously distributed offending Allowed Product(s) and any related
Allowed Product(s) (collectively, a “Cessation Cure”). Within two (2) days after Licensor receives
written notice from Licensee of a violation of the Quality Standards, the Relationship and
Technical Managers of the Licensee and Licensor will, in good faith, collaborate on determining a
Cure protocol. A successful Cessation Cure is deemed to be a Cure approved by Licensor.

ARTICLE 2 – COLLABORATION AND RELATIONSHIP MANAGEMENT

2.1. To facilitate Licensee’s gaining familiarity with respect to the Technology licensed
hereunder and to try to anticipate and/or resolve any disputes or differences that may arise under
or in connection with this Agreement and/or the parties’ collaboration, the parties shall implement
and follow the following relationship management structure:

(a) Each party shall designate a Relationship Manager with respect to this Agreement. The
Relationship Manager shall be a senior manager or officer of the designating party familiar with
the strategy of the company and of this Agreement. The Relationship Managers shall be responsible
for the day-to-day supervision of the parties’ relationship and the obligations of the parties
hereunder. The Relationship Managers shall meet in person at least once per calendar quarter, and
by telephone at least once per calendar month, to accomplish at least the following: (i) review
progress of the matters covered by this Agreement, and in particular the development of any Allowed
Products and/or sublicensing of the Technology, (ii) outline key actions and strategies in
furtherance of the parties’ relationship, (iii) attempt to resolve any issues that have arisen, or
are foreseen as possibly arising, in connection with the performance of this Agreement, and (iv)
discuss possible public statements about the matters covered in this Agreement. The frequency of
the in-person and telephone meetings set forth herein may be changed by mutual agreement of the
Relationship Managers, and it is contemplated that fewer such meetings and phone calls will be
necessary as the parties’ relationship, and Licensee’s familiarity with the Technology, progress.

(b) Each party shall designate a Technical Manager with respect to this Agreement. The
Technical Manager shall be a senior technology manager or officer familiar with the Technology, the
strategy of the company, and this Agreement. The Technical Managers shall meet in person at least
once per calendar quarter, and by telephone at least once per calendar month, to accomplish at
least the following: (i) to review progress of the matters covered by this Agreement and (ii) to
address and attempt to resolve any issues that have arisen, or are foreseen as possibly arising, in
connection with the Technology. The frequency of the in-person and telephone meetings set forth
herein may be changed by mutual agreement of the Technical Managers, and it is contemplated that
fewer such meetings and phone calls will be necessary as the parties’ relationship, and Licensee’s
familiarity with the Technology, progress. At least once per calendar year during a meeting of the
Relationship Managers, Licensor shall update Licensee with information pertaining to upcoming
patents and patent strategy related to Allowed Products.

(c) The parties’ initial, respective Relationship Managers and Technical Managers are set
forth in Schedule 4 to this Agreement. Each party may change its designees from time to time by
giving notice to the other party; however, absent exigent circumstances, each party may do this not
more often than once every two calendar quarters.

2.2 Licensor will use best efforts in connection with its research relating to refining the
applicable Technology, keeping Licensee informed as to research and technology matters as they
impact Licensee’s business and this Agreement, and supporting the transfer of technical information
and materials to Licensee, provided that Licensor shall not be so obligated to the extent Licensor
is under a written confidentiality agreement that would prohibit such or such is commercially
unreasonable. In carrying out the purposes and goals of this Agreement and furthering the parties’
relationship hereunder, Licensee will use best efforts in connection with its research relating to
refining the applicable Technology, supporting the transfer of technical information and materials
to Licensee, seeking governmental approvals (as applicable), Commercializing and fully developing
markets for Allowed Products, and keeping Licensor informed as to such matters and any relevant
research results or information as they impact Licensor’s business and this Agreement. The parties
intend and expect that each will use best efforts in carrying out their obligations hereunder, and
that they will make substantial use of the relationship management structure set forth in Section
2.1 to increase the efficiency, effectiveness, and timeliness with which they carry out such
obligations and keep each other timely informed of relevant developments and information.

2.3 (a) If any dispute between the parties arises under this Agreement, a lawsuit in which the
complaining party does not in good faith seek a temporary restraining order or preliminary
injunction shall not be filed unless and until the parties have complied with the following
informal dispute resolution process:

(i) One party sends written notice to the other that it is invoking the informal dispute
resolution process of this Section 2.3 and setting forth in reasonable detail the nature of the
dispute (the “Notice of Dispute”);

(ii) The Relationship Managers (or other mutually agreeable persons) of the parties shall
attempt to resolve the dispute for 45 days after the Notice of Dispute;

(iii) If the Relationship Managers (or other mutually agreeable persons) are unable to resolve
the dispute within 45 days after the Notice of Dispute; the parties’ respective CEO’s (or other
executives acting as their designees) shall attempt to resolve the dispute for an additional 45
days;

(iv) If the parties’ respective CEO’s (or other executives acting as their designees) are
unable to resolve the dispute within the additional 45 days, a lawsuit regarding matters reasonably
identified in the Notice of Dispute may thereafter be filed.

(b) If the complaining party in good faith seeks a preliminary injunction, but not a temporary
restraining order, the process of Section 2.3(a)(i)-(iv) applies except that the periods during
which the Relationship Managers and the CEO’s (or other executives acting as their designees)
attempt to resolve the dispute shall be reduced from 45 days to 5 days.

(c) If the complaining party in good faith seeks a temporary restraining order, the process of
Section 2.3(a)(i)-(iv) shall not apply.

(d) If a court determines that the complaining party sought a temporary retraining order or
preliminary injunction without arguable grounds and for the purpose of avoiding the dispute
resolution procedures of Section 2.3, the court shall award reasonable attorneys fees and costs to
the other party.

ARTICLE 3 — LICENSE GRANT

3.1 Subject to all other terms and conditions of this Agreement, Licensor hereby grants to
Licensee an exclusive, non-transferable right and license under and to the Technology to use the
Technology in the Territory during the Term to manufacture and process Allowed Products in the
Territory during the Term, which Allowed Products may be non-exclusively promoted, marketed,
offered for sale, sold, imported and exported worldwide (except not to or in Mexico with respect to
tissues) subject to all applicable laws and regulations.

3.2 The license in Section 3.1 is sublicensable to Asian Parties subject to the written
approval of Licensor, which approval shall not be unreasonably withheld, and such sublicenses are
further sublicensable to other Asian Parties subject to the written approval of Licensor, which
approval shall not be unreasonably withheld. Notwithstanding anything else in this Agreement,
Licensor shall at all times retain discretion for qualitative and quantitative considerations to
protect its brands, economics, business, and intellectual property.

3.3 If Licensee is approached for business by a Non-Asian Party’s operating subsidiary or
venture located in the Territory for a relationship with Licensee for manufacturing and/or
processing inside the Territory and sales in whole or part outside the Territory, Licensee must
first refer this entity to Licensor. If Licensor chooses not to pursue this entity, Licensee,
after receiving written permission from Licensor which shall not be unreasonably withheld, may then
pursue and enter into such an agreement with this entity. In this event, if Licensor pays to
Licensee 200% of the Total Cost expended or incurred by Licensee in product development with such
entity, then Licensor shall receive 100% of the revenues from sales outside the Territory
thereafter.

3.4 Subject to all other terms and conditions of this Agreement, Licensor hereby grants to
Licensee a non-exclusive, non-transferable, non-sublicensable right and license under and to the
Technology to use the Technology during the Term for the purpose of developing enhancements to the
Technology. Licensor shall be the sole owner of any and all improvements or enhancements to the
Technology, and Licensee shall promptly report to Licensor the results of any and all enhancements,
improvements, and other research and development relating to the Technology.

3.5 Notwithstanding anything else in this Agreement, Licensor retains and has an unlimited
right to enter into license agreements for worldwide sales, manufacture, processing, and any and
all other activities with any Non-Asian Party.

3.6 If Licensor is approached for business by an Asian Party’s operating subsidiary or venture
located outside the Territory for a relationship with Licensor for manufacturing and/or processing
inside the territory and sales in whole or part outside the Territory, Licensor must first refer
this entity to Licensee. If Licensee chooses not to pursue this entity, Licensor, after receiving
written permission from Licensee which shall not be unreasonably withheld, may then pursue and
enter into such an agreement with this entity. In this event, if Licensee pays to Licensor 200% of
the Total Cost expended or incurred by Licensor in product development with such entity, then
Licensee shall receive 100% of the revenues from sales inside the Territory thereafter.

3.7 Licensee shall not during the Term pursue Technology-related business with any Non-Asian
Party or provide any incentive to any Non-Asian Party to become or attempt to become an Asian
Party. Licensor shall not, and shall contractually require that any future licensees of the
Technology shall not, during the Term pursue any Technology-related business with any Asian Party
or provide any incentive to any Asian Party to become or attempt to become a Non-Asian Party.

3.8 Subject to all other terms and conditions of this Agreement, Licensor hereby grants to
Licensee a non-exclusive, non-transferable, and royalty-free right and license to use the
Trademarks solely in conjunction with the marketing, sale, and distribution of Allowed Products
authorized by this Agreement and compliant with the Quality Standards set forth in Section 3.8(d).
In connection with such license and this Agreement:

(a) Licensee acknowledges Licensor’s sole ownership of the Trademarks, and all associated
goodwill, and that Licensor retains all right, title, and interest in and to the Trademarks and
associated goodwill. All goodwill arising from use of the Trademarks shall inure solely to the
benefit of Licensor. As between Licensor and Licensee, registration and any other form of
protection for the Trademarks shall only be obtained by Licensor according to Licensor’s sole
discretion;

(b) Licensee shall not use the Trademarks in a manner that will diminish or otherwise damage
Licensor’s reputation or goodwill in the Trademarks. Licensee shall not adopt, use, or register
any corporate name, trade name, trademark, domain name, service mark or certification mark, or
other designation confusingly similar to the Trademarks;

(c) Licensee shall take all steps and provide all materials, cooperation and assistance,
reasonably required to assist Licensor in maintaining and enforcing the Trademarks. Licensee shall
notify Licensor of (i) any actual or suspected infringement or misuse of the Trademarks by a third
party, (ii) any information that may adversely affect the Trademarks, and/or (iii) any challenge to
the Trademarks. Licensor shall have the sole right to, and in its sole discretion may, initiate
and/or control any action or proceeding concerning the Trademarks. In the event of any third-party
challenge to Licensor’s right to use the Trademarks, Licensor has the right to require Licensee to
refrain from using any of the Trademarks subject to the challenge;

(d) Licensee warrants that all Allowed Products marketed, sold, or distributed in connection
with the Trademarks under the license set forth in Section 3.1 shall: (i) meet or exceed standards
of quality and performance generally accepted in the industry, (ii) meet or exceed standards of
quality and interpretations of any applicable self-governing or regulating organizations, and (iii)
comply with all applicable laws, rules, and regulations (collectively (i), (ii), and (iii) are the
“Quality Standards”). Licensee shall use the Trademarks solely in connection with Allowed
Products that meet the Quality Standards; and

(e) Licensee shall cooperate with Licensor to facilitate periodic review of Licensee’s and any
sublicensee’s use of the Trademarks and compliance with the Quality Standards. Licensee shall
within five (5) days notify Licensor in writing the details of any violation of the Quality
Standards that Licensee becomes aware of. Licensee shall correct and remedy any deficiencies in
its use of the Trademarks or brand image of Licensor and/or its conformance to the Quality
Standards within ten (10) days after Licensee becomes aware (through notice or otherwise) of any
such deficiencies. Licensee’s failure to do so shall entitle Licensor to terminate the license set
forth in Section 3.8 immediately upon written notice.

3.9 The license in Section 3.8 is sublicensable to parties validly sublicensed by Licensee (or
its sublicensees) to sell Allowed Products, subject to the written approval of Licensor, which
approval shall not be unreasonably withheld. Notwithstanding anything else in this Agreement,
Licensor shall at all times retain discretion for qualitative and quantitative considerations to
protect its brands, economics, business, and intellectual property.

3.10 If Licensor delivers to Licensee standard operating procedures or other specifications
with respect to the Technology or any product, Licensee shall follow such standard operating
procedures or specifications, and any Licensee changes to or departures from the standard operating
procedures or other specifications shall only be made after prior written approval by Licensor, in
its sole discretion, is received by Licensee. In addition, any and all improvements or further
fields of use of the licensed Technology shall immediately be reported in writing by Licensee to
the Licensor prior to any application or testing of such for Licensor’s written approval. Further,
if any additional testing, as Licensor determines in its sole discretion, is required to understand
the effect of any such Licensee requested change to or departure from the standard operating
procedures or other specifications, an Allowed Product, or otherwise, Licensor shall be allowed to
conduct any and all testing it shall determine is appropriate prior to approving of any such change
or departure.

3.11 Notwithstanding anything else in this Agreement, Licensee shall not pursue or enter into
any business agreement or relationship with CSL Limited or any of its subsidiaries or affiliated
entities (including without limitation any of the companies in the CSL Group). Notwithstanding
anything else in this Agreement, Licensor is free to enter into any business agreement or
relationship with CSL Limited or any of its subsidiaries or affiliated entities (including without
limitation any of the companies in the CSL Group), regardless of the agreement’s or relationship’s
or entity’s connection with the Territory and regardless of any exclusivity of any license to
Licensee.

ARTICLE 4 — LICENSEE PAYMENTS AND OBLIGATIONS

4.1 (a) In consideration for the access to and use of the Technology, Licensee shall pay
Licensor non-recoupable, non-refundable payments totaling $5,000,000 as follows:

	 	 	 	 	 
	Timing

	 	Amount

	 

	 	 	 	 
	 
	 	 	 	 
	by October 31, 2005

	 	$	500,000	 
	 

	 	 	 	 
	 
	 	 	 	 
	by January 31, 2006

	 	$1,000,000

(subject to increase as set forth

in Section 4.1(b))

	
 
	 	 	 	 
	 
	 	 	 	 
	by October 31, 2006

	 	$	1,000,000	 
	 

	 	 	 	 
	 
	 	 	 	 
	by January 31, 2007

	 	$	1,000,000	 
	 

	 	 	 	 
	 
	 	 	 	 
	by October 31, 2007

	 	$	1,000,000	 
	 

	 	 	 	 
	 
	 	 	 	 
	by October 31, 2008

	 	$	500,000	 
	 

	 	 	 	 

(b) Notwithstanding anything else in this Agreement, the first $1,000,000 payment set forth in
the chart in Section 4.1(a) shall be increased to $1,250,000 if Licensee fails to raise $5,000,000
in financing on or before January 31, 2006 to be used solely to develop and Commercialize Allowed
Products, as verified to Licensor on or before February 10, 2006.

1

4.2 In consideration of the rights and licenses herein granted by Licensor to Licensee,
Licensee shall pay to Licensor the following royalty on Gross Revenues:

	 	 	 	 	 
	Year of Agreement	 	Royalty Rate on Gross Revenues
	1st through end of 5th
	 	 	7.5	%
	 
	 	 	 	 
	6th through end of 10th
	 	 	10.0	%
	 
	 	 	 	 
	11th and each year thereafter
	 	 	12.5	%
	 
	 	 	 	 

4.3 In further consideration of the rights and licenses herein granted by Licensor to
Licensee, Licensee shall pay to Licensor the following recoupable, non-refundable, minimum royalty
(“Minimum Royalty Payment”) for each year of the Agreement, payable within ten (10) days
following the beginning of the applicable year as set forth below:

	 	 	 	 	 
	Year of Agreement
	 	Minimum Royalty Payment

	 	 	 
	1st
	 	$	0	 
	 
	 	 	 	 
	2nd
	 	$	0	 
	 
	 	 	 	 
	3rd
	 	$	0	 
	 
	 	 	 	 
	4th
	 	$	0	 
	 
	 	 	 	 
	5th
	 	$	0	 
	 
	 	 	 	 
	6th and for each year beyond
	 	$250,000 each year
	 
	 	 	 	 

4.4 Any royalty payment to be made under Section 4.2 shall be applicable toward recoupment of
only the Minimum Royalty Payment paid in the same year of the Agreement. When the aggregate
Licensee royalty payments due under Section 4.2 for a given year exceed the Minimum Royalty Payment
for that same year of the Agreement, Licensee shall pay Licensor any accrued, unpaid excess amount
within thirty (30) days following the end of the calendar quarter. Such payments to Licensor shall
be accompanied by a statement showing Gross Revenues on a country-by-country basis together with
all information relevant to the computation of any royalties payable hereunder (including, but not
limited to, the Allowed Products billed and collected broken down by sublicensee, category, product
and price), and the payment amount due and payable pursuant to the terms of this Agreement.

4.5 All payments made hereunder shall be paid in United States dollars, and shall be made by
wire transfer to the account specified by Licensor. To the extent any Gross Revenues are received
in non-U.S. currency, royalty payments with respect to such Gross Revenues shall be paid in U.S.
dollars converted from the non-U.S. currency at the rate of exchange quoted by The Wall Street
Journal, on the last business day of the month in which the Gross Revenues giving rise to the
royalty payment were received.

4.6 Licensee shall keep and shall require all sublicensees to keep complete, true and accurate
records of all Gross Revenues, all sales, distribution, and other transfers of each Allowed
Product, and all data necessary for the computation of payments to be made to Licensor hereunder
for at least three (3) years following the period in which such obligation arose. Licensor, at
Licensor’s expense, shall be given access to Licensee’s and sublicensees’ records, which shall be
made available by Licensee at a single location in the continental United States, upon thirty (30)
days written notice by Licensor, during reasonable business hours for the purpose of auditing them
and verifying any payments (or lack thereof) made under this Agreement. Licensor may only conduct
one (1) audit of Licensee per calendar year. Notwithstanding the previous statement, Licensee
reserves the right to authorize Licensor additional audits beyond the one (1) per calendar year
allowed; however, the terms under which these additional audits are conducted may differ from the
terms specified in this Section 4.6. In the event that a discrepancy is determined to exist and
such discrepancy is greater than five percent (5%) of the amount reported by Licensee, the costs
incurred by Licensor for such audit shall be borne by Licensee, provided that if two consecutive
audits (not necessarily of consecutive payment periods) disclose discrepancies of between 2% and 5%
(inclusive), the costs incurred by Licensor for the second of such audits shall be borne by
Licensee. If an audit reveals that Licensee has underpaid any owed amount to Licensor, Licensee
shall immediately pay such unpaid or underpaid amount to Licensor, but if such payment is disputed
in good faith by Licensee, Licensee may make such payment subject to a reservation of its rights.

4.7 Withholding tax, if any, levied on any royalty and/or on any other payments to be paid
hereunder, will be paid by Licensee to the proper taxing authority and proof of payment will be
sent to Licensor. Any such withholding tax paid by Licensee, may not be deducted from and/or
credited against the royalty due to Licensor. In addition, payments made hereunder shall be
exclusive of any VAT due and the end user is responsible to account for VAT under the
self-reporting / reverse charge mechanism.

4.8 Licensee shall pay interest to Licensor on overdue payments at the lesser of one percent
(1%) per month or the highest rate allowed by applicable law, until paid. Licensee shall be deemed
in material breach of this Agreement in the event that any such sums are in arrears for more than
sixty (60) days.

4.9 Licensee shall use best efforts to Commercialize each Allowed Product. Licensee shall use
best efforts to fully develop the markets for each Allowed Product which has been Commercialized
and within ninety (90) days from such date of Commercialization.

4.10 Licensor shall have the right, at any time, to inspect and investigate the manufacturing
and processing units of Licensee (or any sublicensee) for the Allowed Products upon thirty (30) day
prior written notice by Licensor to Licensee. This right to investigate also includes the right to
investigate the running manufacturing processes for the Allowed Products in the manufacturing
units.

4.11 Licensee shall provide Licensor with all information and evidence to be submitted to any
regulatory authorities in connection with the approval requirements for each of the Allowed
Products. Such information and evidence shall include, but is not limited to, the manufacturing
protocols for the Allowed Products. Licensee shall inform Licensor about any amendments in said
protocols within ten (10) days after submission of such, provided, however, that if such amendments
in said protocols affect the Allowed Product or the application of the Technology on the Allowed
Product then Licensee shall provide Licensor reasonable notice prior to such submission.

4.12 Licensee shall not attempt to or in fact sell, transfer, assign, or otherwise encumber
any right or interest in the Agreement, the Technology, or the Trademarks, except for allowed
sublicenses granted by Licensee in the ordinary and normal course of its business as proposed to be
conducted as of November 4, 2004. Any and all sublicensees shall be contractually required not to
sell, transfer, assign, or otherwise encumber any right or interest in any sublicense, the
Technology, or the Trademarks.

4.13 Notwithstanding anything else in this Agreement, if Licensee pays Licensor an aggregate
of $5 million in royalty payments under Section 4.2 (which amount does not include any other
payment under this Agreement) prior to the end of year 10 of this Agreement, Licensee shall not be
required to pay the Minimum Royalty Payments set forth in Section 4.3 from that point through the
end of year 10 of this Agreement.

4.14 In any agreement that Licensee enters into with a third party regarding the Technology or
Allowed Products, Licensee shall include written provisions ensuring that no third party is
purported to be given greater rights or fewer restrictions with respect to the Technology or
Trademarks than Licensee hereunder and fully preserving the rights that Clearant has with respect
to such third parties as set forth in this Agreement. By way of some examples, but not in any
respect limitations, any sublicense (and any sublicense of any sublicense, etc.) shall require
sublicensee to agree in writing: to not pursue Technology-related business or provide incentives to
the same extent as prohibited of Licensee in Section 3.7, to use best efforts to Commercialize
Allowed Products as Licensee is required to do under Section 4.9, to agree to Licensor’s ownership
of all developments as set forth in Section 7.1, to agree to the same confidentiality obligations
as Licensee under Article 9, and to agree to the same indemnification obligations as Licensee under
Article 11.

ARTICLE 5 — EQUITY INTEREST IN LICENSEE

5.1 Licensee shall grant Licensor, at no cost, a 10% preferred equity interest in Licensee
based on a fully diluted post-equity financing basis calculation (including all common stock,
preferred stock, and common stock equivalents, options, warrants, convertible securities, and
similar securities) within fifteen (15) days after aggregate financing of at least $10,000,000 from
unrelated third parties. Such preferred equity interest shall be issued in any one of the
securities, at Licensor’s sole option, that Licensee has sold to raise financing of at least
$10,000,000. If no such financing has occurred, Licensor, at its sole option, shall have the right
to take such equity interest in any prior issued security of Licensee, at no cost.

5.2 In connection with Licensor’s equity interest granted in Section 5.1, Licensee shall be
granted and have preemptive rights to maintain its ownership pro rata by investing capital with new
investors (on the same terms) in connection with Licensee’s sales of additional equity securities.
Licensor shall be granted and have other standard rights granted to the other investors in such
financing, including without limitation registration rights, co-sale rights, and information
rights.

ARTICLE 6 — LICENSOR’S FIRST REFUSAL, PURCHASE, AND 

BOARD OBSERVATION RIGHTS

6.1 At Licensor’s request in its sole discretion, Licensee shall sell Licensee to Licensor for
a purchase price of the Fair Market Value of Licensee upon each occurrence of any of the following:

(a) seven days before Licensee has a public offering;

(b) Licensee receives a commercially reasonable, unsolicited, written offer (including the
identity of a third party and indicating its interest and the terms thereof) for the purchase of a
Controlling Interest which the Board of Directors of Licensee intends to pursue; or

(c) the Board of Directors of Licensee solicits and receives a commercially reasonable
indication of interest from a third party to purchase a Controlling Interest.

Before Licensee shall make a public offering, Licensee shall give Licensor one hundred twenty (120)
days written notice of its intent to do so, for the purpose of Licensor being given a reasonable
opportunity to determine the Fair Market Value of Licensee and whether to purchase Licensee. If
within fourteen (14) days thereafter Licensor does not give written notice of its intent to make a
Fair Market Value determination in connection with a decision whether to purchase under Section
6.1(a), Licensor shall not purchase Licensee in connection with such public offering. In the event
of a third-party offer under Section 6.1(b) or indication of interest under Section 6.1(c),
Licensee shall give Licensor written notice of such offer or indication of interest within ten (10)
days after receipt thereof. If within fourteen (14) days after such notice Licensor does not give
written notice of its intent to make a Fair Market Value determination in connection with a
decision whether to purchase under Section 6.1(b) or 6.1(c), Licensor shall not purchase Licensee
in connection with such offer or indication of interest; otherwise Licensor shall be given at least
fourteen (14) days after a determination of Fair Market Value in connection with such offer or
indication of interest to give notice of an intent to purchase under Section 6.1(b) or 6.1(c), and
Licensee shall not engage in any transaction with the third party prior to the end of that period
that may render more difficult or costly such purchase.

6.2 Beginning on the fifth (5th) anniversary of the Effective Date, Licensor shall have the
right to purchase Licensee at a total purchase price equal to the Fair Market Value of Licensee.

6.3 If a particular determination of Fair Market Value under Section 1.6(b) results in the
purchase of Licensee by Licensor, then the costs and fees relating the valuations by Investment
Bank A, Investment Bank B, and Investment Bank C (whichever such valuations are conducted) shall be
paid from the proceeds of the sale. If a particular determination of Fair Market Value under
Section 1.6(b) does not result in the purchase of Licensee by Licensor, then Licensor shall bear
the costs and fees of the valuation thereunder of Investment Bank A, Licensee shall bear the costs
and fees of the valuation thereunder of Investment Bank B (if conducted), and the parties shall
evenly share the costs and fees of the valuation thereunder of Investment Bank C (if conducted).

6.4 Licensee shall give Licensor reasonable notice of meetings of the Board of Directors of
Licensee and the opportunity for a representative chosen by Licensor to attend such board meetings
as a non-voting observer. Licensee shall also provide Licensee’s representative with the same
information, at the same time, as is provided to Board members.

ARTICLE 7 — INTELLECTUAL PROPERTY

7.1 Licensor shall be the owner of any and all intellectual property related to or resulting
from the Technology, the licenses granted by this Agreement and sublicenses resulting therefrom,
the irradiation of biologics, and the Clearant Process, including without limitation the conditions
under which the Clearant Process may be carried out, and any improvements thereto, regardless of
what person or entity discovers or develops them. This includes, but is not limited to, patents
and patent applications, any and all unpatented inventions (whether or not patentable), copyrights,
trade secrets, tangible research property, technical data and other information and intellectual
property solely or jointly conceived, made, reduced to practice, or learned by Licensee,
sublicensees, and/or venturers with Licensee or sublicensees.

7.2 Licensee shall, within the Territory, protect and maintain the validity and enforceability
of the Technology and Trademarks, and shall not allow any of the Technology or Trademarks to be
abandoned, forfeited, or dedicated to the public without the written consent of Licensor. Licensee
shall monitor the Territory for, and promptly provide written notification to Licensor in the event
of, any third party infringement or misappropriation, or possible infringement or misappropriation,
of the Technology or Trademarks in whole or in part. Upon receipt of such notice, Licensor shall
have the right (but not the obligation), in its sole discretion, to take action against actual or
suspected infringers or other violators and any and all recoveries resulting from such actions by
Licensor shall be retained by Licensor. Any and all costs and expenses, including but not limited
to legal fees, for acquisition, maintenance, litigation of, or other protection of, rights in or to
the Technology or Trademarks in the Territory shall be borne by, or if initially paid by Licensor
promptly reimbursed by, Licensee as they are incurred. In the event of any monetary recovery by
Licensor in a litigation or proceeding covered by this Section 7.2, Licensee shall be entitled to
have any moneys it actually paid in connection with the litigation or proceeding reimbursed from
any net moneys, if any, actually received after Licensor has been reimbursed for any and all fees
and expenses it has paid or incurred in connection with obtaining the proceeds.

7.3 Licensee shall report to Licensor, promptly and in written detail, each claim of patent
infringement made or threatened by a third party against Licensee as a result of Licensee’s
manufacture, use or sale of the Allowed Products.

ARTICLE 8 — NON-SOLICITATION AND NON-COMPETE

8.1 During the Term and for two (2) years thereafter, Licensee shall not directly or
indirectly encourage, solicit, recruit, or hire, or assist others to directly or indirectly
encourage, solicit, recruit, or hire, any full- or part-time employee, or director of Licensor that
(i) is then working for or with Licensor in any capacity or (ii) had been working for or with
Licensor in any capacity any time during the one-year period before such encouraging, solicitation,
recruiting, or hiring. Notwithstanding the previous sentence, Licensor consents to Licensee
recruiting and hiring William Drohan, Randy Kent, Billy Burgess, Shirley Miekka, and/or Martin
MacPhee, provided that, absent written consent from Licensor, Licensee shall not communicate with
William Drohan, Randy Kent, Martin MacPhee, or any other Clearant employee for at least thirty (30)
days after the Effective Date in connection with an actual or possible position with Licensee.
Notwithstanding the foregoing, Licensor consents to Licensee utilizing consultants who are working
for or with Licensor who are not current or prior employees or directors of Licensor, provided that
Licensee’s good-faith use of such consultants (limited exclusively to a consulting role) does not
interfere with any of the consultant’s obligations to Licensor, or cause any disruption whatsoever
in the business of Licensor. As an example, suppose consultant John agrees to attend a meeting on
behalf of Licensor. If Licensee needed consultant John to complete a task during the time John
would be attending Licensor’s meeting, under these terms, Licensee must defer and require John to
complete the task around his schedule with Licensor. If Licensee desires to utilize a consultant in
a role beyond consulting (i.e. hiring to a full- or part-time basis), it may only do so after
receiving the express written permission of Licensor.

8.2 During the Term and for two (2) years thereafter, Licensee shall not directly or
indirectly call on, take phone calls from, meet, or otherwise solicit business from, any actual or
potential customer of Licensor known by Licensee to be targeted by Licensor outside the Territory,
or assist others to do so. Licensee acknowledges that such actual and potential customers include,
but are not limited to, CSL Limited and its subsidiaries or affiliated entities (including without
limitation the companies in the CSL Group).

8.3 The obligations set forth in Sections 8.1 — 8.2 are essential elements of this Agreement.
Licensee is receiving adequate consideration in exchange for these obligations (and all other
obligations in the Agreement) and these obligations are reasonable and necessary in order to
protect the legitimate rights and interests of Licensor in its intellectual property, its
confidential and proprietary information, and otherwise.

ARTICLE 9 — CONFIDENTIALITY

9.1 The recipient of Confidential Information under or in connection with this Agreement from
the other party shall treat such Confidential Information so as to preserve its confidentiality,
with at least that level of care that the recipient treats its own Confidential Information.
Access to the Confidential Information shall be limited to employees of the recipient who have the
need to know the information to effectuate the purpose of this Agreement and who are under a
written obligation of confidentiality to the recipient at least to the same extent as the recipient
is bound under this Agreement.

9.2 The obligations set forth in Section 9.1 do not apply to Confidential Information when,
after, and only to the extent it:

(a) was known to the recipient before disclosure under this Agreement as evidenced by written
records created and dated prior to the disclosure under this Agreement, an issue upon which the
recipient shall bear the burden of proof;

(b) is or becomes a matter of public knowledge through no fault of the recipient, an issue
upon which the recipient shall bear the burden of proof;

(c) is disclosed by the recipient with the prior written approval of the party
disclosing the information;

(d) is disclosed to the recipient by a third party with the lawful right to disclose the
Confidential Information without a duty of confidentiality, where the third party lawfully obtained
the information independently of either party to this Agreement, an issue upon which the recipient
shall bear the burden of proof; or

(e) is disclosed as required by law after taking reasonable steps to inform the disclosing
party and providing an opportunity to object or otherwise act.

9.3 All Confidential Information furnished under this Agreement shall be and remain the
exclusive property of the disclosing party except as otherwise provided by Section 7.1, and the
receiving party shall promptly return to the disclosing party, upon the disclosing party’s request,
all documents, samples and other material in the possession, custody or control of the receiving
party that bear or incorporate any part of the Confidential Information, including all copies made
by the receiving party; provided that the receiving party may retain one copy for the purposes of
complying with this Agreement.

ARTICLE 10 — REPRESENTATIONS AND WARRANTIES

10.1 Licensor hereby represents and warrants to Licensee that:

(a) it has the full right, power and authority, and has obtained all approvals, permits or
consents necessary, to enter into this Agreement and to perform all of its obligations hereunder
and to grant the licenses provided hereunder;

(b) it has not, prior to the Effective Date of this Agreement, entered into any agreement or
otherwise granted any now existing, or agreed to grant any future, license, right or privilege that
conflicts in any way with this Agreement; and

(c) it has and will maintain, for at least three (3) years after the termination of this
Agreement, commercial general liability insurance, including products liability coverage, covering
conduct it may undertake, products it may manufacture or sell, and events that may occur in
connection with or relating to its compliance with its conduct and/or obligations under this
Agreement, in an amount and nature adequate and reasonable under the circumstances and commensurate
with such insurance as is customary in the industry in connection with similar risks and
agreements.

10.2 Licensee hereby represents and warrants to Licensor that:

(a) it has the full right, power and authority, and has obtained all approvals, permits or
consents necessary, to enter into this Agreement and to perform all of its obligations hereunder;

(b) this Agreement does not conflict with Licensee’s obligations under any other agreement or
law;

(c) to its knowledge, neither the preparation nor the sale or distribution of the Allowed
Products will infringe or otherwise conflict with any laws or any rights of any third party;

(d) it has and will maintain, for at least three (3) years after the termination of this
Agreement, commercial general liability insurance, including products liability coverage, covering
conduct it may undertake, products it may manufacture or sell, and events that may occur in
connection with or relating to its compliance with its conduct and/or obligations under this
Agreement, in an amount and nature adequate and reasonable under the circumstances and commensurate
with such insurance as is customary in the industry in connection with similar risks and
agreements;

(e) Licensee shall not use any confidential or proprietary information of Licensor known to
any current or former employee of Licensor (including but not limited to William Drohan and Martin
MacPhee) other than Confidential Information and/or Technology provided to or licensed to Licensee
under this Agreement; and

(f) it will use all commercially reasonable efforts to raise $5,000,000 in financing on or
before January 31, 2006 to be used solely to develop and Commercialize Allowed Products, and
provide proof to Licensor of such financing on or before February 10, 2006, these dates being
material and of the essence.

10.3. LICENSOR EXPRESSLY DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A
PARTICULAR PURPOSE. LICENSOR PATENT AND TECHNOLOGY RIGHTS ARE PROVIDED “AS IS.” LICENSEE HEREBY
ACKNOWLEDGES AND AGREES THAT LICENSOR MAKES NO REPRESENTATIONS OR WARRANTIES THAT THE RIGHTS AND
LICENSES GRANTED BY LICENSOR TO LICENSEE HEREUNDER CONSTITUTE ALL RIGHTS AND LICENSES NECESSARY OR
DESIRABLE TO PROCESS, MANUFACTURE OR TRANSFER THE ALLOWED PRODUCTS.

10.4. IN NO EVENT SHALL LICENSOR BE LIABLE TO LICENSEE FOR ANY SPECIAL, CONSEQUENTIAL,
EXEMPLARY OR INCIDENTAL DAMAGES (INCLUDING, WITHOUT LIMITATION, LOST OR ANTICIPATED REVENUES OR
PROFITS) FOR ANY CLAIM RELATING TO THIS AGREEMENT, OR FOR DAMAGES OR OTHER MONIES, INDIVIDUALLY OR
IN THE AGGREGATE, EXCEEDING THE AMOUNTS ACTUALLY PAID TO LICENSOR HEREUNDER IN THE TWELVE-MONTH
PERIOD PRECEDING ANY CLAIM RELATING TO THIS AGREEMENT, WHETHER SUCH CLAIM IS BASED ON WARRANTY,
CONTRACT, TORT (INCLUDING NEGLIGENCE OR STRICT LIABILITY) OR OTHERWISE, EVEN IF AN AUTHORIZED
REPRESENTATIVE OF LICENSOR IS ADVISED OF THE POSSIBILITY OR LIKELIHOOD OF THE SAME. LICENSEE
ACKNOWLEDGES AND AGREES THAT ANY SUCH PAYMENT BY LICENSOR SHALL BE THE SOLE AND FINAL REMEDY IN
EXHAUSTION OF AND IN PLACE OF ALL OTHER REMEDIES HEREUNDER AND THAT SUCH REMEDY SHALL NOT BE DEEMED
OR ALLEGED BY LICENSEE TO BE INSUFFICIENT OR TO HAVE FAILED OF ITS ESSENTIAL PURPOSE. IN NO EVENT
SHALL LICENSEE BE LIABLE TO LICENSOR FOR ANY SPECIAL CONSEQUENTIAL, EXEMPLARY OR INCIDENTAL DAMAGES
OR FOR THE LOSS OF PROFITS ARISING FROM THE PERFORMANCE OR NONPERFORMANCE OF THIS AGREEMENT OR ANY
ACTS OR OMISSIONS ASSOCIATED HEREWITH.

10.5 IN NO EVENT SHALL LICENSOR BE LIABLE TO ANY SUBLICENSEE FOR ANY REASON OR GROUND
WHATSOEVER RELATING TO ANY SUBLICENSE, THIS AGREEMENT, LICENSEE, THE TECHNOLOGY, THE CLEARANT
PROCESS, OR THE TRADEMARKS. EACH AND EVERY SUBLICENSEE SHALL WAIVE ANY WAIVABLE RIGHTS AND CLAIMS
OF SUCH KINDS AGAINST LICENSOR IN WRITING, AND SHALL EXECUTE A WRITTEN COVENANT NOT TO SUE LICENSOR
WITH RESPECT TO SUCH MATTERS, AS A MATERIAL CONDITION OF ANY SUBLICENSE.

ARTICLE 11 — COMPLIANCE, INDEMNIFICATION AND INSURANCE

11.1 Licensee shall indemnify, defend, and hold harmless Licensor and its affiliated companies
and its and their respective officers, directors, agents and employees from and against all third
party liabilities, demands, damages, expenses and losses (including reasonable attorneys’ fees)
arising out of or in connection with (a) Licensee’s breach of the representations, warranties,
obligations and covenants under this Agreement, (b) the manufacture, use, distribution and/or sale
of any and all Allowed Products (the “Indemnified Losses”), or (c) any lawsuit or other proceeding
brought by any sublicensee that is disallowed under the language of Section 10.5, except to the
extent indemnified by Licensor pursuant to Section 11.4.

11.2 Licensee shall use best efforts in a timely fashion to conduct all of its operations in
relation to Allowed Products in accordance with all applicable laws, regulations, requirements, and
other standards, which may be in effect from time-to-time, of all pertinent governmental
authorities, including, without limitation, standards for the validation and processing of Allowed
Products.

11.3 Licensee shall exercise a reasonable standard of care in conducting its activities
relating to Allowed Products and Technology, including without limitation any sublicensing,
testing, manufacture, packaging, marketing, advertising, distribution and sale.

11.4 Licensor shall indemnify, defend, and hold harmless Licensee and its affiliated companies
and its and their respective officers, directors, agents and employees from and against all
Indemnified Losses resulting from Licensor’s breach of the representations, warranties, obligations
and covenants under this Agreement.

ARTICLE 12 — TERM AND TERMINATION

12.1 The Term of this Agreement shall be from the Effective Date through and including the
twentieth (20th) anniversary of the Effective Date, unless and until this Agreement is terminated
earlier in accordance with the provisions of Article 12. If at the end of the twentieth (20th)
anniversary of the Effective Date this Agreement has not been terminated, it shall automatically be
extended for up to three (3) additional ten-year terms, each of which shall take effect
automatically if the Agreement has not been terminated as the preceding term comes to an end.

12.2 This Agreement may be terminated by either party upon written notice in the event that
the other party:

(a) materially breaches the Agreement, in which case the Agreement may be terminated in
accordance with Section 12.3;

(b) files a petition for insolvency, bankruptcy or liquidation or the commencement of any such
proceeding against either party that is not discharged within ninety (90) days thereafter;

(c) makes a general assignment for the benefit of its creditors;

(d) ceases to conduct its business; or

(e) has a receiver appointed for it or its business.

12.3 Upon any curable material breach or default by either party under this Agreement, this
Agreement may be terminated, by the other party upon sixty (60) days written notice to the
breaching or defaulting party (“Notice Period”), provided that with respect to a breach or default
for non-compliance with the standard operating procedures or the process for changes thereto under
Articles 2, 3 or 4, the Notice Period shall be ten (10) days. Such notice shall become effective
at the end of such Notice Period, unless such breach or default is cured during such Notice Period.
Upon any material breach or default by either party under this Agreement that cannot reasonably be
cured, or upon a party’s breach of any warranty under this Agreement, this Agreement may be
terminated by the other party immediately upon notice. In the event Licensee fails to cure a
breach for non-payment under Section 4.1 within the Notice Period, Licensor’s sole remedy shall be
cancellation of the license.

12.4 Upon termination of this Agreement, Licensee shall immediately cease developing, making,
having made, using, promoting, processing, producing, marketing, representing, offering for sale or
distribution, selling, distributing, importing, or exporting Allowed Products, and all rights and
licenses granted to Licensee hereunder shall automatically and immediately terminate.

12.5 Notwithstanding anything else in this Agreement, this Agreement may be terminated by
Licensor upon written notice if:

(a) Licensee or any sublicensee fails to conform to applicable standards, regulations, or
guidelines of any applicable governmental agency, resulting in a suspension of manufacturing or
sales of Allowed Products or use of the Technology, and fails to cure such failure and resume
manufacturing or sales within thirty (30) days after notice thereof;

(b) any Allowed Product that is materially harmful or unsafe to intended recipients if used as
intended is made available to an end user, and Licensee fails to effect a successful Cure within
eighteen (18) days after Licensee becomes aware (through notice or otherwise);

(c) Licensee fails to effect a successful Cure of a violation of the Quality Standards within
eighteen (18) days after Licensee becomes aware (through notice or otherwise) of the violation;

(d) a governmental, regulatory, or self-governing agency or entity determines that any Allowed
Product is materially harmful or unsafe, and Licensee fails to effect a successful Cure within
eighteen (18) days after Licensee becomes aware (through notice or otherwise);

(e) Licensee uses any of the Trademarks in any way, or with any product or service, likely to
diminish or damage the Trademarks or brand image of Licensor or the Technology, and the same or
similar use continues or occurs more than ten (10) days after Licensee becomes aware (through
notice or otherwise); or

(f) Licensee fails to notify Licensor in writing the details of any violation of the Quality
Standards that Licensee or any sublicensee becomes aware of (through notice or otherwise), within
five (5) days after Licensee or any sublicensee becomes aware of the violation. Although Licensee
will use its reasonable best efforts to ensure all sublicensees conform to the applicable Quality
Standards, in the event Licensee becomes aware that a sublicensee has failed to inform Licensee of
a Quality Standards violation, Licensee shall not be in breach of this Agreement if it enacts a
Cessation Cure with respect to the sublicensee and applicable violation within three (3) days after
discovery of the violation.

12.6 The expiration or termination of this Agreement shall not affect any rights or
obligations of the parties under this Agreement that are intended by the parties to survive such
expiration or termination or which have accrued prior to such expiration or termination. Without
limiting the generality of the foregoing, the following provisions of this Agreement shall survive
expiration or termination hereof: Section 2.3, Sections 4.1 — 4.8, Article 5, Article 6, Article 7,
Article 8, Article 9, Article 10, Section 11.1, Section 11.4, and Section 13.11. In addition, any
other provision required to interpret and enforce the parties’ rights and obligations under this
Agreement shall also survive, but only to the extent required for the full observation and
performance of this Agreement.

12.7 If Licensee is a party to any claim against Licensor for infringement, invalidity,
unenforceability or the like relative to any of the Technology or opposes the issuance of any of
Licensor’s patents included within the Technology, Licensor shall have the option to immediately
terminate this Agreement and upon such termination Licensee shall immediately cease developing,
making, having made, using, promoting, processing, producing, marketing, representing, offering for
sale or distribution, selling, distributing, importing, or exporting Allowed Products, and all
rights and licenses granted to Licensee hereunder shall automatically and immediately terminate.

ARTICLE 13 — MISCELLANEOUS

13.1 This Agreement constitutes the entire understanding between the parties with respect to
the obligations of the parties hereto and supersedes and replaces all prior agreements,
understandings, writings and discussions between the parties relating to the subject matter of this
Agreement.

13.2 Other than with respect to an obligation solely to pay money, any material breach of this
Agreement by Licensee will cause, and constitutes, irreparable harm to Licensor for which Licensor
has no adequate remedy at law, and thus any such material breach would entitle Licensor to
injunctive and preliminary injunctive relief to enforce this Agreement and/or protect its
intellectual property, in addition to damages and any other available remedies.

13.3 This Agreement may be amended, and any of its terms or conditions may be waived, only by
a written instrument executed by the parties or, in the case of a waiver, by a written instrument
executed by the waiving party. The failure of either party at any time or times to require
performance of any provision hereof shall in no manner affect such party’s right at a later time to
enforce the same provision in connection with subsequent performance of such provision. No waiver
by either party of any condition or term in any one or more instances shall be construed as a
further or continuing waiver of such condition or term or of any other condition or term.

13.4 Any delay in or failure of performance by either party under this Agreement shall not be
considered a breach of this Agreement if and to the extent such delay or failure is caused by an
occurrence or occurrences beyond the reasonable control of the party affected, including but not
limited to acts of God; acts, regulations or laws of any government; strikes or other concerted
acts of workers; fires; floods; explosions; riots; illness; death; incapacity; disability; wars;
terrorism; rebellion and sabotage; and any time for performance hereunder shall be extended by the
actual time of delay caused by such occurrence.

13.5 Any notice required or permitted to be given hereunder shall be mailed by registered or
certified mail return receipt requested or by overnight courier or delivered by hand to the party
to whom such notice is required or permitted to be given. Delivery of any notice shall be deemed
to have occurred upon receipt of such notice.

All designations and written disclosures of Confidential Information, and reports sent
hereunder, to Licensor shall be addressed as follows:

Clearant, Inc.

11111 Santa Monica Blvd., Suite 650

Los Angeles, CA 90025

Attn: Andrew Jacobson

All notices to Licensor shall be addressed as follows:

Clearant, Inc.

11111 Santa Monica Blvd., Suite 650

Los Angeles, CA 90025

Attn: Donald Lewis

All designations and written disclosures of Confidential Information, and reports sent
hereunder, to Licensee shall be addressed as follows:

TriStar Bioventures International

1505 Gilman Blvd. NW,

Suite #4A

Issaquah, WA 98027

Attn: Eric Luttio

All notices to Licensee shall be addressed as follows:

TriStar Bioventures International

1505 Gilman Blvd. NW,

Suite #4A

Issaquah, WA 98027

Attn: Eric Luttio

Each party may change its foregoing information for receiving notices and disclosures hereunder
upon seven (7) days written notice to the other.

13.6 This Agreement shall not be assignable by any party without the written consent of the
non-assigning party. Notwithstanding the preceding sentence or anything else in this Agreement,
Licensor may assign or transfer its rights and obligations under this Agreement to a party that
succeeds to all or substantially all Licensor’s business or assets whether by sale, merger,
operation of law or otherwise; provided that any such assignee or transferee agrees in writing
prior to the assignment or transfer that upon the assignment or transfer it shall be fully bound by
the terms and conditions of this Agreement. This Agreement shall be binding upon and inure to the
benefit of and be enforceable by the parties hereto and their respective successors and permitted
assignees, including without limitation those resulting from sale, merger, or otherwise.

13.7 Each party hereto is an independent contractor and not a joint venturer, principal, agent
or partner of the other, and neither shall enter into or have the right to enter into any
agreement, shall incur or commit or have the right to incur or commit the other in any manner, or
shall make or have the right to make any representation on behalf of the other, without the prior
written consent of such other.

13.8 Licensor and Licensee acknowledge that if Licensor as a debtor in possession or through a
trustee in bankruptcy in a case under the Bankruptcy Code rejects the Agreement, Licensee may elect
to retain rights under the Agreement as provided in, and in accordance with, Section 365(n) of the
Bankruptcy Code. In such event, upon written request of the Licensee to Licensor or the Bankruptcy
Trustee, Licensor or such Bankruptcy Trustee shall not interfere with the rights of Licensee as
retained under and in accordance with Section 365(n) of the Bankruptcy Code.

13.9 The language used in this Agreement shall be deemed to be the language chosen by both
parties hereto to express their mutual intent. Neither party shall be deemed or considered to be
the sole or primary drafter, and no rule of strict construction for or against either party shall
apply to any term, condition, or provision of this Agreement. Each party had the benefit of
counsel in negotiating, drafting, reviewing, and understanding this Agreement, and is freely
executing this agreement after all such consideration, review, and advice as it believes
appropriate.

13.10 The headings contained in this Agreement are for convenience only and shall not affect
the interpretation of this Agreement. In this Agreement, the words “include” and “including” shall
be deemed to be followed by “without limitation,” the words “hereof” and “herein” and “hereunder”
refer to this Agreement as a whole, and the singular includes the plural and vice versa.

13.11 If any provision or provisions of this Agreement (or any portion or portions thereof)
are held to be invalid, void, illegal, or unenforceable for any reason by a court of competent
jurisdiction, the validity, legality and enforceability of the remaining provisions of this
Agreement shall not in any way be affected or impaired and shall continue in full force and effect,
and the provisions of this Agreement shall be construed and interpreted, to the fullest extent
legally possible, to give effect to the intent of any provision or portion held invalid, void,
illegal or unenforceable.

13.12 In any action or proceeding arising out of or relating to this Agreement or any party’s
rights under or in connection with this Agreement, the court or other ruling authority shall
determine which party, if either, is the prevailing party for the purpose of awarding attorneys
fees (or whether no party was the prevailing party for such purposes), and shall award such
prevailing party, if any, its reasonable attorneys fees and expenses.

13.13 This Agreement shall be governed by and construed in accordance with the internal laws
of the State of California, without consideration of its choice of law rules. Any lawsuit or other
proceeding arising out of or under this Agreement shall be filed in the United States District
Court for the Central District of California, which the parties acknowledge and agree shall have
jurisdiction over the issues and the parties and shall be an appropriate venue, and the parties
shall and do submit themselves to the jurisdiction of such court for purposes of this Agreement and
waive any waivable right to make any objection to such court based on jurisdiction, venue, or
otherwise.

13.14 This Agreement may be executed in counterparts, each of which shall be deemed an
original, but all of which together shall constitute one and the same instrument.

* * * * *

IN WITNESS WHEREOF, the undersigned are duly authorized to execute this Agreement on behalf of
Licensor and Licensee, as applicable.

CLEARANT, INC. TRISTAR BIOVENTURES INTERNATIONAL

	 	 	 	 	 	 	 
	
 
	 	/s/ Alain Delongchamp
	 	 	 	/s/ Eric Luttio
	 

	 	 
	 	 
	 	 
	Name:

Title:

Date:

	 	Alain Delongchamp

Chief Executive Officer

April 8, 2005
	 	Name:

Date:
	 	Eric Luttio

Title: Chief Executive Officer

April 8, 2005
	 
	 	 	 	 	 	 
	
 
	 	/s/ Donald Lewis
	 	 	 	/s/ Anthony Salter
	 

	 	 
	 	 
	 	 
	Name:

Title:

Date:

	 	Donald Lewis

Chief Financial Officer

April 8, 2005
	 	Name:

Title:

Date:
	 	Anthony Salter

Vice-President of Business Development

April 8, 2005

2

Schedule 1

Allowed Products

Pharmaceutical products

Blood products

Allograft tissue implants

Nutraceuticals

Cosmetic products

Food products

Veterinary products

3

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