Document:

PROMISSORY NOTE
                                 ---------------

                                      FROM:
                                      ----

                                DERMISONICS, INC.
                                -----------------

                                      TO:
                                       --

                          NEWPORT CAPITAL CORPORATION
                          ---------------------------

                                DERMISONICS, INC.
                                -----------------
Suite 1000, 789 West Pender Street, Vancouver, British Columbia, Canada, V6C 1H2

                                   ----------

<PAGE>
                                PROMISSORY NOTE
                                ===============

                             TO THE PROMISSORY NOTE
                             ----------------------
                      BETWEEN THE BORROWER AND THE LENDER
                      -----------------------------------
                       Principal Sum ofU.S. $1,146,732.00
                       ----------------------------------

Principal:  U.S. $1,146,732.00.     Made at Vancouver, British Columbia, Canada.
            ------------------

Maturing:   APRIL 19, 2011.
            --------------

          THIS  PROMISSORY  NOTE is provided, dated and made effective as of the
          ----------------------
19th  day  of  April,  2007  (the  "Effective  Date").

FROM:
----

          DERMISONICS,  INC., a company incorporated under the laws of the State
          ------------------
          of  Nevada,  U.S.A., and having an address for notice and delivery and
          executive  offices  located  at  Suite  1000,  789 West Pender Street,
          Vancouver,  British  Columbia,  Canada,  V6C  1H2

          (the "Borrower");
                                                               OF THE FIRST PART
                                                               -----------------

TO:
--

          NEWPORT  CAPITAL  CORPORATION,  a company having an address for notice
          -----------------------------
          and  delivery  located  at  Rennweg  28,  CH-8001, Zurich, Switzerland

          (the  "Lender");
                                                              OF THE SECOND PART
                                                              ------------------

          (the  Borrower  and  the  Lender  being  hereinafter  singularly  also
          referred to as a "Party" and collectively referred to as the "Parties"
          as  the  context  so  requires).

          FOR  VALUABLE  CONSIDERATION,  receipt whereof is hereby acknowledged,
          ----------------------------
the undersigned, Borrower, hereby owes and promises to pay to the Lender, or the
holder  of  this promissory note (the "Promissory Note"), in accordance with the
terms  and  conditions  referenced  herein,  the  aggregate principal sum of one
million  one hundred and forty-six thousand seven hundred and thirty-two dollars
(U.S.  $1,146,732.00) in lawful money of the United States (hereinafter referred
to  as  the  "Principal  Sum")  together  with  simple  interest accruing on the
Principal  Sum  and  commencing  on  the above-referenced Effective Date of this
Promissory Note at the rate of six percent (6.0%) per annum, and not in advance,
both  before  and  after default, maturity and judgment (herein the "Interest");
with  any  such  outstanding  Interest  to  be  payable in full to the Lender on
repayment  of  the  Principal  Sum  in  the  manner  as  set  forth  immediately
hereinbelow  (and  with  the totality of the within Principal Sum advance by the
Lender  to the Borrower being the "Loan" hereunder); and with said Principal Sum
and  corresponding  Loan hereby representing the full and complete value and the
settlement  of  any

<PAGE>
                                      -2-

and  all  indebtedness which was heretofore due and owing by the Borrower to the
Lender  under  each  of the "Underlying Notes" (as hereinafter defined) with the
Borrower.

                              Repayment of the Loan
                              ---------------------

          The Principal Sum of this Loan, together with all outstanding Interest
accrued  thereon  as  specified  hereinabove,  is  hereby  irrevocably  and
unconditionally  due  and  payable by the Borrower to the order and direction of
the  Lender  in  Vancouver,  British  Columbia,  Canada,  at or before 5:00 p.m.
(Vancouver,  British  Columbia,  Canada,  time)  on  April  19, 2011 (the "Final
Principal  Sum  Payment  Date").

          The  Borrower  may  prepay and redeem any portion of the Principal Sum
portion  of  the Loan, and its then related Interest, in whole or in part at any
time  prior  to the Final Principal Sum Payment Date (the "Right of Redemption")
and  in  the manner as set forth immediately hereinbelow by providing the Lender
with  no  less  than  five  calendar days' prior written notice (the "Redemption
Notice")  of  its  Right  of Redemption intention to redeem and repay all or any
portion of the Principal Sum and any Interest accrued thereon which would be due
and  owing  by  the  Borrower  to  the Lender at the end of such five-day period
(collectively,  the  "Redemption  Amount") (such day at the end of such five-day
period  being the "Redemption Date" and, for clarity, such Redemption Date would
be the date to which such Principal Sum and Interest would be calculated and due
and  payable  to  the  Lender  at  the  close of business, in Vancouver, British
Columbia,  Canada,  on  such  Redemption  Date).

          In  order  to  provide  such  Redemption  Notice  the Borrower will be
required, at the date of its delivery to the Lender of the Redemption Notice, to
provide to the Lender's counsel, or to such other mutually agreeable holder (the
"Escrow  Holder"),  a  certified  cheque  or  bank draft representing the entire
Redemption  Amount and made payable to the Lender in funds of the United States,
or  funds  by way of wire transfer to such designation as may be directed by the
Lender in its sole and absolute discretion, in the amount of any such Redemption
Amount.  Thereupon,  and should the proposed Redemption Amount in fact represent
all of the Principal Sum and any Interest accrued thereon which would be due and
owing  by  the  Borrower  to  the Lender under this Promissory Note and the Loan
Agreement at the Redemption Date, then the Lender will be required to provide to
the  Escrow  Holder, and as soon as reasonably possible after its receipt of the
Redemption  Notice,  all  such  registerable  discharges  as may be necessary to
relieve  the  Borrower  of  any  obligation  to  the  Lender  under each of this
Promissory  Note  (collectively,  the "Discharges").  On the second business day
subsequent  to  the  Redemption  Date  the  Escrow  Holder, if applicable, shall
deliver to the Lender the Redemption Amount and, only if also applicable, to the
Borrower  the  Discharges,  and,  unless  otherwise  directed  in writing by the
Parties  prior  thereto,  to  the  Parties'  respective addresses for notice and
delivery  as  set  forth  on  the  front  page  of  this  Promissory  Note.

                   Background of the Loan and entire agreement
                   -------------------------------------------

          The  Parties  hereby  acknowledge and agree that the subject Principal
Sum  was  assigned  by  Berra  Holdings  Ltd.  (the "Assignor") to the Lender in
accordance  with  the  terms  and  conditions  of  a certain "Assignment Of Debt
Agreement", dated for reference as of the Effective Date hereof (the "Assignment
Agreement"),  as  entered  into among the Assignor, the Lender and the Borrower,
and  pursuant  to  which  the  Assignor therein assigned to the Lender, with the
acknowledgement  and  the  consent  of  the Borrower, 75% of the Assignor's then
indebtedness  from  the Borrower under the terms and conditions of each of those
certain  "Promissory  Note"s, dated for reference January 26, 2005, February 14,
2005,  March  4,  2005, May 13, 2005, June 6, 2005, June 9, 2005, June 23, 2005,
July  15,  205,  July  27, 2005, August 18, 2005, August 30, 2005, September 28,
2005,  October  6,  2005,  October  14,  2005,  November  16,  2005, December 5,

<PAGE>
                                      -3-

2005 and March 17, 2006, respectively (collectively, the "Underlying Notes"), as
previously  provided  by  the  Borrower  to  the  Assignor.

          The  Parties  hereby also acknowledge and agree that, in consideration
of the within issuance of this Promissory Note by the Borrower to the Lender for
the  full  and complete value and the settlement of each of the underlying loans
as  assigned  to the Lender from the Assignor under the Assignment Agreement and
respecting  the  Underlying Notes, the within Promissory Note, and the Principal
Sum  Loan  and Interest represented hereby, now constitutes the entire agreement
to date between the Parties hereto and respecting the within Loan and supersedes
every  previous  agreement,  expectation,  negotiation,  representation  or
understanding,  whether  oral  or  written,  express  or  implied,  statutory or
otherwise,  between  the  Parties  with  respect  to  the subject matter of this
Promissory  Note  and including, without limitation, the terms and conditions of
each of the Underlying Notes as assigned by the Assignor to the Lender under the
Assignment  Agreement.

                               General provisions
                               ------------------

          The  holder  of  this  Promissory  Note  may, from time to time, grant
written  indulgences with respect to certain payment amounts or periods but such
indulgences  will  not  in  any way affect the undersigned's liability upon this
Promissory  Note  nor  will  such  indulgences  vary  any  other  term  to which
indulgence has not specifically been granted.  No indulgence will be enforceable
against  the  holder  unless  granted  in  writing.

          The  undersigned hereby waives demand, presentment for payment, notice
of  non-payment  and  protest.

          If  any  provision  of  this  Promissory  Note  is held to be invalid,
illegal  or  unenforceable,  then  such  will not affect or impair the validity,
legality  or  enforceability  of  the  remaining  provisions.

          WITNESS  the  hands  of  the authorized representatives of each of the
          -------
undersigned  Parties  given  under  seal  as  of  the  Effective Date determined
hereinabove.

The  COMMON  SEAL  of                              )
DERMISONICS, INC.,                                 )
-----------------
the  Borrower  herein,                             )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )

The  COMMON  SEAL  of                              )
NEWPORT CAPITAL CORPORATION,                       )
---------------------------
the  Lender  herein,                               )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )
                                   ----------PROMISSORY NOTE
                                ===============

                                      FROM:
                                      ----

                                DERMISONICS, INC.
                                -----------------

                                       TO:
                                       --

                           NEWPORT CAPITAL CORPORATION
                           ---------------------------

                                DERMISONICS, INC.
                                -----------------
Suite 1000, 789 West Pender Street, Vancouver, British Columbia, Canada, V6C 1H2
                                   ----------

<PAGE>
                                 PROMISSORY NOTE
                                 ===============

                             TO THE PROMISSORY NOTE
                             ----------------------
                      BETWEEN THE BORROWER AND THE LENDER
                      -----------------------------------
                        Principal Sum ofU.S. $250,000.00
                        --------------------------------

Principal:  U.S. $250,000.00.       Made at Vancouver, British Columbia, Canada.
            ----------------

Maturing:  APRIL 19, 2011.
           --------------

          THIS  PROMISSORY  NOTE is provided, dated and made effective as of the
          ----------------------
19th  day  of  April,  2007  (the  "Effective  Date").

FROM:
----

          DERMISONICS,  INC., a company incorporated under the laws of the State
          ------------------
          of  Nevada,  U.S.A., and having an address for notice and delivery and
          executive  offices  located  at  Suite  1000,  789 West Pender Street,
          Vancouver,  British  Columbia,  Canada,  V6C  1H2

          (the "Borrower");
                                                               OF THE FIRST PART
                                                               -----------------

TO:
--

          NEWPORT  CAPITAL  CORPORATION,  a company having an address for notice
          -----------------------------
          and  delivery  located  at  Rennweg  28,  CH-8001, Zurich, Switzerland

          (the  "Lender");
                                                              OF THE SECOND PART
                                                              ------------------

          (the  Borrower  and  the  Lender  being  hereinafter  singularly  also
          referred to as a "Party" and collectively referred to as the "Parties"
          as  the  context  so  requires).

          FOR  VALUABLE  CONSIDERATION,  receipt whereof is hereby acknowledged,
          ----------------------------
the undersigned, Borrower, hereby owes and promises to pay to the Lender, or the
holder  of  this promissory note (the "Promissory Note"), in accordance with the
terms  and  conditions  referenced  herein,  the  aggregate principal sum of two
hundred  and  fifty  thousand  dollars (U.S. $250,000.00) in lawful money of the
United  States  (hereinafter  referred  to as the "Principal Sum") together with
simple  interest  accruing  on  the  Principal  Sum  and  commencing  on  the
above-referenced  Effective  Date  of  this  Promissory  Note at the rate of six
percent  (6.0%)  per  annum,  and not in advance, both before and after default,
maturity  and  judgment  (herein  the  "Interest");  with  any  such outstanding
Interest  to  be payable in full to the Lender on repayment of the Principal Sum
in the manner as set forth immediately hereinbelow (and with the totality of the
within  Principal  Sum  advance  by  the Lender to the Borrower being the "Loan"
hereunder);  and  with  said  Principal  Sum  and  corresponding  Loan  hereby
representing  the  full  and  complete  value  and the settlement of any and all
indebtedness  which  was  heretofore  due  and  owing  by  the

<PAGE>
                                      -2-

Borrower  to  the  Lender  under  each of the "Underlying Notes" (as hereinafter
defined)  with  the  Borrower.

                              Repayment of the Loan
                              ---------------------

          The Principal Sum of this Loan, together with all outstanding Interest
accrued  thereon  as  specified  hereinabove,  is  hereby  irrevocably  and
unconditionally  due  and  payable by the Borrower to the order and direction of
the  Lender  in  Vancouver,  British  Columbia,  Canada,  at or before 5:00 p.m.
(Vancouver,  British  Columbia,  Canada,  time)  on  April  19, 2011 (the "Final
Principal  Sum  Payment  Date").

          The  Borrower  may  prepay and redeem any portion of the Principal Sum
portion  of  the Loan, and its then related Interest, in whole or in part at any
time  prior  to the Final Principal Sum Payment Date (the "Right of Redemption")
and  in  the manner as set forth immediately hereinbelow by providing the Lender
with  no  less  than  five  calendar days' prior written notice (the "Redemption
Notice")  of  its  Right  of Redemption intention to redeem and repay all or any
portion of the Principal Sum and any Interest accrued thereon which would be due
and  owing  by  the  Borrower  to  the Lender at the end of such five-day period
(collectively,  the  "Redemption  Amount") (such day at the end of such five-day
period  being the "Redemption Date" and, for clarity, such Redemption Date would
be the date to which such Principal Sum and Interest would be calculated and due
and  payable  to  the  Lender  at  the  close of business, in Vancouver, British
Columbia,  Canada,  on  such  Redemption  Date).

          In  order  to  provide  such  Redemption  Notice  the Borrower will be
required, at the date of its delivery to the Lender of the Redemption Notice, to
provide to the Lender's counsel, or to such other mutually agreeable holder (the
"Escrow  Holder"),  a  certified  cheque  or  bank draft representing the entire
Redemption  Amount and made payable to the Lender in funds of the United States,
or  funds  by way of wire transfer to such designation as may be directed by the
Lender in its sole and absolute discretion, in the amount of any such Redemption
Amount.  Thereupon,  and should the proposed Redemption Amount in fact represent
all of the Principal Sum and any Interest accrued thereon which would be due and
owing  by  the  Borrower  to  the Lender under this Promissory Note and the Loan
Agreement at the Redemption Date, then the Lender will be required to provide to
the  Escrow  Holder, and as soon as reasonably possible after its receipt of the
Redemption  Notice,  all  such  registerable  discharges  as may be necessary to
relieve  the  Borrower  of  any  obligation  to  the  Lender  under each of this
Promissory  Note  (collectively,  the "Discharges").  On the second business day
subsequent  to  the  Redemption  Date  the  Escrow  Holder, if applicable, shall
deliver to the Lender the Redemption Amount and, only if also applicable, to the
Borrower  the  Discharges,  and,  unless  otherwise  directed  in writing by the
Parties  prior  thereto,  to  the  Parties'  respective addresses for notice and
delivery  as  set  forth  on  the  front  page  of  this  Promissory  Note.

                   Background of the Loan and entire agreement
                   -------------------------------------------

          The  Parties  hereby  acknowledge and agree that the subject Principal
Sum  was  assigned  by Staples Management Inc. (the "Assignor") to the Lender in
accordance  with  the  terms  and  conditions  of  a certain "Assignment Of Debt
Agreement", dated for reference as of the Effective Date hereof (the "Assignment
Agreement"),  as  entered  into among the Assignor, the Lender and the Borrower,
and  pursuant  to  which  the  Assignor therein assigned to the Lender, with the
acknowledgement  and  the  consent  of  the Borrower, 75% of the Assignor's then
indebtedness  from  the Borrower under the terms and conditions of each of those
certain  "Convertible  Promissory  Note"s, dated for reference July 14, 2006 and
October  3,  2006,  respectively  (collectively,  the  "Underlying  Notes"),  as
previously  provided  by  the  Borrower  to  the  Assignor.

<PAGE>
                                      -3-

          The  Parties  hereby also acknowledge and agree that, in consideration
of the within issuance of this Promissory Note by the Borrower to the Lender for
the  full  and complete value and the settlement of each of the underlying loans
as  assigned  to the Lender from the Assignor under the Assignment Agreement and
respecting  the  Underlying Notes, the within Promissory Note, and the Principal
Sum  Loan  and Interest represented hereby, now constitutes the entire agreement
to date between the Parties hereto and respecting the within Loan and supersedes
every  previous  agreement,  expectation,  negotiation,  representation  or
understanding,  whether  oral  or  written,  express  or  implied,  statutory or
otherwise,  between  the  Parties  with  respect  to  the subject matter of this
Promissory  Note  and including, without limitation, the terms and conditions of
each of the Underlying Notes as assigned by the Assignor to the Lender under the
Assignment  Agreement.

                               General provisions
                               ------------------

          The  holder  of  this  Promissory  Note  may, from time to time, grant
written  indulgences with respect to certain payment amounts or periods but such
indulgences  will  not  in  any way affect the undersigned's liability upon this
Promissory  Note  nor  will  such  indulgences  vary  any  other  term  to which
indulgence has not specifically been granted.  No indulgence will be enforceable
against  the  holder  unless  granted  in  writing.

          The  undersigned hereby waives demand, presentment for payment, notice
of  non-payment  and  protest.

          If  any  provision  of  this  Promissory  Note  is held to be invalid,
illegal  or  unenforceable,  then  such  will not affect or impair the validity,
legality  or  enforceability  of  the  remaining  provisions.

          WITNESS  the  hands  of  the authorized representatives of each of the
          -------
undersigned  Parties  given  under  seal  as  of  the  Effective Date determined
hereinabove.

The  COMMON  SEAL  of                              )
DERMISONICS, INC.,                                 )
-----------------
the  Borrower  herein,                             )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )

The  COMMON  SEAL  of                              )
NEWPORT CAPITAL CORPORATION,                       )
---------------------------
the  Lender  herein,                               )
was  hereunto  affixed  in  the  presence  of:     )                    (C/S)
                                                   )
                                                   )
---------------------------------------------------)
Authorized  Signatory                              )
                                   ----------

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