Document:

Exhibit 10.49

Exhibit 10.49

SETTLEMENT AGREEMENT AND AMENDMENT TO LICENSE AGREEMENT

THIS SETTLEMENT AGREEMENT AND AMENDMENT TO LICENSE AGREEMENT (“Agreement”) is entered into as
of this 24th day of November, 2009 (“Effective Date”) by and between QLT INC., a Canadian
corporation formerly known as QLT Therapeutics, Inc. (“QLT”), and THE GENERAL HOSPITAL CORPORATION,
d/b/a Massachusetts General Hospital, a Massachusetts non-profit corporation (“MGH”).

WHEREAS, QLT and MGH are joint owners of U.S. Patent No. 5,793,349 (the “‘349 Patent”), and
entered into a License Agreement, effective December 8, 1998, (the “License Agreement”) regarding
the ‘349 Patent and “Patent Rights” relating thereto as defined therein;

WHEREAS, QLT and MGH are parties to a lawsuit in the United States District Court for the
District of Massachusetts, Civil Action No. 09-cv-10364 (WGY) (“the Lawsuit”), regarding the ‘349
Patent, the License Agreement, a Side-Letter to the License Agreement dated December 4, 1998, and
various issues in connection therewith and related to a series of separate actions involving
Massachusetts Eye and Ear Infirmary (“MEEI”);

WHEREAS, QLT and MGH have agreed to settle the Lawsuit, amend the License Agreement, and
release all claims in connection with the subject matter of the Lawsuit and License Agreement
(except such claims as may arise from this Agreement) in accordance with the terms of this
Agreement.

NOW, THEREFORE, in consideration of the foregoing promises and mutual covenants and conditions
contained herein and other good and valuable consideration, the sufficiency of which is hereby
acknowledged, the parties agree as follows:

	 	1.	 	Payment and Amendment to License Agreement: In consideration of the terms and
conditions hereof, QLT shall pay MGH the total sum of $20,000,000 (twenty million dollars).
This sum shall be paid by wire transfer, as directed by MGH in writing, and shall be made
no later than December 1, 2009. This amount shall constitute payment in full of all
royalty obligations under the License Agreement, through the expiration of the ‘349 Patent
and related Patent Rights, and upon receipt of this payment, the License Agreement shall be
considered fully paid up. This payment shall be in full and complete satisfaction of all
obligations QLT has, may have, or may have had under any circumstances in connection with
the subject matter of the Lawsuit, the License Agreement, the Patent Rights, and sales of
Visudyne anywhere in the world, and QLT shall have no other or further payment obligations
to MGH, or to any person or entity affiliated with MGH, in connection therewith. For
avoidance of doubt, the parties further agree that the Side Letter dated December 4, 1998,
is now void and of no further force or effect.

 

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	 	2.	 	MGH Release of QLT: In consideration of the payment and amendment of the
License Agreement set forth herein, MGH, on behalf of itself and its officers, directors,
employees, and any other current or formerly affiliated persons or entities who may claim
any right to compensation in connection with the subject matter of the Lawsuit, License
Agreement, Patent Rights, or sales of Visudyne (the “MGH Releasors”), hereby releases QLT
and its officers, directors, employees, and any other current or formerly affiliated
persons or entities who acted for or on behalf of QLT in connection with the subject matter
of the Lawsuit, License Agreement, Patent Rights, or sales of Visudyne (the “QLT
Releasees”) from and against any and all claims or causes of action, of whatever nature,
the MGH Releasors have, have had, or may have against the QLT Releasees relating in any way
to the subject matter of the Lawsuit, the License Agreement, the Patent Rights, or sales of
Visudyne anywhere in the world, from the beginning of time and through the end of time,
except for claims arising out of the express terms of this Agreement and except for claims
arising from future conduct with respect to provisions of the License Agreement that are
not amended or affected by this Agreement (e.g., QLT’s going forward indemnification
obligations). QLT represents that there are no current claims against it that would
trigger indemnification obligations under the License Agreement.

	 	3.	 	QLT Release of MGH: In consideration of the terms and conditions hereof, QLT,
on behalf of itself and its officers, directors, employees, and any other current or
formerly affiliated persons or entities who acted for or on behalf of QLT in connection
with the subject matter of the Lawsuit, License Agreement, Patent Rights, or sales of
Visudyne (the “QLT Releasors”), hereby releases MGH and its officers, directors,
employees, and any other current or formerly affiliated persons or entities who acted for
or on behalf of MGH in connection with the subject matter of the Lawsuit, License
Agreement, Patent Rights, or sales of Visudyne (the “MGH Releasees”) from and against any
and all claims or causes of action, of whatever nature, the QLT Releasors have, have had,
or may have against the MGH Releasees relating in any way to the subject matter of the
Lawsuit, the License Agreement, the Patent Rights, or sales of Visudyne anywhere in the
world, from the beginning of time and through the end of time, except for claims arising
out of the express terms of this Agreement and except for claims arising from future
conduct with respect to provisions of the License Agreement that are not amended or
affected by this Agreement (e.g., MGH’s warranty that it has not assigned or conveyed any
interest in the Patent Rights inconsistent with the rights granted to QLT).

	 	4.	 	Dismissal of the Lawsuit: Within 3 (three) business days of the receipt by MGH
of the payment set forth in Paragraph 1 above, the parties shall execute and file a
stipulation of dismissal, (a) dismissing the Lawsuit referred to above, and all claims and
counterclaims asserted in connection therewith, with prejudice; and (b) providing that the
United States District Court for the District of Massachusetts shall retain jurisdiction
solely for the purpose of enforcing the provisions of this Agreement.

	 	5.	 	Power to Enter into This Agreement: QLT and MGH each represent and warrant
that they have the power to enter into this Agreement, and all of the provisions, covenants
and releases set forth herein, and that they have not transferred or otherwise assigned any
of the claims or causes of action that have been released in connection herewith.

 

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	 	6.	 	Execution of Documentation: The parties agree to cooperate fully and to
execute any and all supplementary documents and take all additional action that may be
necessary and appropriate to give full force and effect to the terms and intent of this
Agreement that are not inconsistent with its terms. Executed facsimile or PDF email
transmissions of this Agreement and such supplementary documentation shall be deemed
originals and shall be fully enforceable.

	 	7.	 	Choice of Law: This Agreement shall be governed by the laws of the
Commonwealth of Massachusetts, without regard to any choice of law principles. The parties
expressly agree that the United States District Court for the District of Massachusetts
shall retain jurisdiction over the Lawsuit solely for the purpose of enforcing this
Agreement. In the event a proceeding is necessary to enforce the terms of this Agreement,
the prevailing party shall be entitled to recover its reasonable attorneys’ fees.

	 	8.	 	Entire Agreement: This Agreement embodies the entire understanding of the
parties. All prior representations and agreements, whether oral or in writing, have been
merged into and replaced by this Agreement. The parties further acknowledge that they have
been represented by counsel, and are not relying on any representations made by the other
in entering into this Agreement. The parties expressly waive any right to seek rescission
of this Agreement or to otherwise assert any claims whatsoever based on the subsequent
discovery of any unknown fact or circumstance that relates in any way to the subject matter
hereof. The parties agree that the Arbitration Agreement dated March 2, 2007 shall not be
impacted by this Agreement and shall remain in full force and effect. The parties are not
currently contemplating invoking arbitration under the Arbitration Agreement.

	 	9.	 	Successors and Assigns: This Agreement shall inure to the benefit of and be
binding upon the Parties and their respective heirs, executors, successors, and assigns.

 

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	 	10.	 	Counterparts: This Agreement may be executed by each of the parties in
counterparts with the same effect as if the Parties had signed the same copy.

	 	 	 
	QLT INC.

	 	THE GENERAL HOSPITAL CORPORATION,

d/b/a Massachusetts General Hospital
	 
	By: /s/ Robert Butchofsky

	 	By: /s/ Frances Toneguzzo
	 
	Name: Robert Butchofsky
	 	Name: Frances Toneguzzo
	 
	Its: President and Chief Executive Officer
	 	Its: Director of Research and Licensing
	 
	Date: November 24, 2009
	 	Date: November 24, 2009

 

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Exhibit 10.1

[TJX Companies, Inc. Letterhead]

September 17, 2009

Mr. Ernie Herrman

The TJX Companies, Inc.

770 Cochituate Road

Framingham, MA 01701

Re:  Amendment to Employment Agreement

Dear Mr. Herrman:

     Reference is made to the Employment Agreement dated as of September 8, 2006 (as subsequently
amended and in effect on the date hereof, the “Existing Agreement”) between you and The TJX
Companies, Inc. (the “Company”). The Existing Agreement and the period of your employment with the
Company under the Existing Agreement were to expire on September 8, 2009 (the “End Date”), except
as otherwise mutually agreed by you and the Company. The Company and you both agree that Section 1
of the Existing Agreement shall be amended so that “End Date” shall mean January 30, 2010. For the
avoidance of doubt, the Company further acknowledges and agrees that your current Base Salary (as
defined in the Existing Agreement) is $925,000 per year.

     If you agree with the foregoing, please so indicate by signing the enclosed copy of this
letter agreement and returning it to Mr. Greg Flores at the Company, whereupon this letter
agreement will take immediate effect as of September 8, 2009. This letter agreement shall
constitute an agreement under seal.

	 	 	 	 	 
	 	The TJX Companies, Inc.

 	 
	 	By:  	/s/ Carol Meyrowitz
 	 
	 	Title:  	President & CEO 	 
	 	 	 	 
	 

Agreed:

	 	 	 
	/s/ Ernie Herrman
 

Ernie Herrman

	 	 
	 
	 	 
	Date: October 15, 2009

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