Document:

EX-10.2

 Exhibit 10.2 
  

 
  

AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 

BY AND AMONG 
 DICERNA
PHARMACEUTICALS, INC. 
 AND 

THE INVESTORS NAMED HEREIN 

DATED AS OF                , 2017 

 
  

 

 This AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (as it may be amended from time to time
in accordance with the terms hereof, the “Agreement”), dated as of                , 2017 is made by and among: 

i. Dicerna Pharmaceuticals, Inc., a Delaware corporation (the “Company”); and 

ii. each Person executing this Agreement and listed as an “Investor” on the signature pages hereto (collectively, together with their
Permitted Transferees that become party hereto, the “Investors”). 
 RECITALS 

WHEREAS, the Company and the Investors entered into that certain Redeemable Convertible Preferred Stock Purchase Agreement, dated as of
March 30, 2017 (the “Purchase Agreement”), pursuant to which the Company is selling, and each Investor is purchasing, on the date hereof, an aggregate of seven hundred thousand (700,000) shares of Preferred Stock; 

WHEREAS, Section 10 of that certain Amended and Restated Registration Rights Agreement, dated as of July 30, 2013, by and among the
Company and the persons identified on the signature pages thereto (the “Existing Registration Rights Agreement”) provides that any provision thereof may be amended or waived with the prior written consent of the Company and an
Investor Majority (as defined in the Existing Registration Rights Agreement); 
 WHEREAS, the undersigned Investors constitute an Investor
Majority; and 
 WHEREAS, this Agreement amends, restates, replaces and supersedes in its entirety the Existing Registration Rights
Agreement. 
 NOW, THEREFORE, in consideration of the foregoing and the mutual promises, covenants and agreements of the parties hereto, and
for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 

ARTICLE I 

EFFECTIVENESS 

Section 1.1. Effectiveness. This Agreement shall become effective upon the closing of the Investment. 

ARTICLE II 
 DEFINITIONS

 Section 2.1. Definitions. As used in this Agreement, the following terms shall have the following meanings: 

 “Affiliate” means, with respect to any specified Person, (a) any Person
that directly or indirectly through one or more intermediaries controls, or is controlled by, or is under common control with, such specified Person, (b) in the event that the specified Person is a natural Person, a Member of the Immediate
Family of such Person or (c) any investment fund advised or managed by, or under common control or management with, such Person; provided that the Company and each of its subsidiaries shall be deemed not to be Affiliates of any Investor.
As used in this definition, the term “control” means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a Person, whether through ownership of voting securities, by
contract or otherwise. 
 “Agreement” shall have the meaning set forth in the preamble. 

“Business Day” means any day that is not a Saturday, a Sunday or other day on which banks are required or authorized by law
to be closed in the City of New York. 
 “Common Stock” means the common stock of the Company, par value $0.0001 per share.

 “Company Indemnitees” shall have the meaning set forth in Section 3.9.5. 

“Conversion Shares” means all shares of Common Stock issuable upon conversion of the Preferred Stock. 

“Demand Notice” shall have the meaning set forth in Section 3.1.3. 

“Demand Registration” shall have the meaning set forth in Section 3.1.1(a). 

“Demand Registration Request” shall have the meaning set forth in Section 3.1.1(a). 

“Demand Registration Statement” shall have the meaning set forth in Section 3.1.1(c). 

“Demand Suspension” shall have the meaning set forth in Section 3.1.6. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and any successor thereto, and any rules and
regulations promulgated thereunder, all as the same shall be in effect from time to time. 
 “Existing Registration Rights
Agreement” shall have the meaning set forth in the recitals. 
 “FINRA” means the Financial Industry Regulatory
Authority. 
 “Holders” means Investors who then hold Registrable Securities under this Agreement. 

“Investment” means the transactions contemplated by the Purchase Agreement. 

“Investor” shall have the meaning set forth in the preamble. 

“Issuer Free Writing Prospectus” means an issuer free writing prospectus, as defined in Rule 433 under the Securities
Act, relating to an offer of the Registrable Securities. 
 “Loss” shall have the meaning set forth in Section 3.9.1.

  
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 “Member of the Immediate Family” means, with respect to any Person who is an
individual, (a) each parent, spouse (but not including a former spouse or a spouse from whom such Person is legally separated) or child (including those adopted) of such individual and (b) each trustee, solely in his or her capacity as
trustee, for a trust naming only one or more of the Persons listed in sub-clause (a) as beneficiaries. 

“Permitted Transferee” means (i) any Affiliate of an Investor and (ii) such other Persons designated with Requisite
Investor Approval. 
 “Person” means any individual, partnership, corporation, company, association, trust, joint venture,
limited liability company, unincorporated organization, entity or division, or any government, governmental department or agency or political subdivision thereof. 

“Piggyback Notice” shall have the meaning set forth in Section 3.3.1. 

“Piggyback Registration” shall have the meaning set forth in Section 3.3.1. 

“Potential Takedown Participant” shall have the meaning set forth in Section 3.2.5(b). 

“Preferred Stock” means the Redeemable Convertible Preferred Stock of the Company, par value $0.0001 per share. 

“Pro Rata Portion” means, with respect to each Holder requesting that its shares be registered or sold in an Underwritten
Public Offering, a number of such shares equal to the aggregate number of Registrable Securities to be registered or sold (excluding any shares to be registered or sold for the account of the Company) multiplied by a fraction, the numerator of which
is the aggregate number of Registrable Securities held by such Holder, and the denominator of which is the aggregate number of Registrable Securities held by all Holders requesting that their Registrable Securities be registered or sold. 

“Prospectus” means (i) the prospectus included in any Registration Statement, all amendments and supplements to such
prospectus, including post-effective amendments and supplements, and all other material incorporated by reference in such prospectus, and (ii) any Issuer Free Writing Prospectus. 

“Public Offering” means the offer and sale of Registrable Securities for cash pursuant to an effective Registration Statement
under the Securities Act (other than a Registration Statement on Form S-4 or Form S-8 or any successor form). 

“Purchase Agreement” shall have the meaning set forth in the recitals. 

“Registrable Securities” means (i) all shares of Common Stock held as of the date hereof; (ii) all shares of
Common Stock issuable upon exercise, conversion or exchange of any option, warrant or convertible security outstanding as of the date hereof and not then subject to vesting or forfeiture to the Company (including, for the avoidance of doubt, any
Conversion Shares into which the Preferred Stock is convertible from time to time after the date hereof) and (iii) all shares of Common Stock directly or indirectly issued or then issuable with respect to the securities referred to in clauses
(i) or (ii) above by way of a stock dividend or stock split, or in 

  
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 connection with a combination of shares, recapitalization, merger, consolidation or other reorganization. As to
any particular Registrable Securities, such securities shall cease to be Registrable Securities when (v) such securities shall have been disposed of in accordance with an effective Registration Statement, (w) such securities shall have
been Transferred pursuant to Rule 144, (x) such holder is able to immediately sell such securities under Rule 144 without any restrictions on transfer (including without application of paragraphs (c), (d), (e), (f) and (h) of Rule 144), as
reasonably determined by the Holder (it being understood that a written opinion of counsel reasonably acceptable to the Company to the effect that such securities may be so offered and sold and that any restrictive legends on the securities may be
removed shall be conclusive evidence that this clause (x) has been satisfied), (y) such securities shall have been otherwise transferred and a new certificate for it not bearing a legend restricting further transfer under the Securities Act
shall have been delivered by the Company, all applicable holding periods shall have expired, and no other applicable and legally binding restriction on transfer by the Holder thereof shall exist under the Securities Act, or (z) such securities
shall have ceased to be outstanding. 
 “Registration” means registration under the Securities Act of the offer and sale to
the public of any Registrable Securities under a Registration Statement. The terms “register”, “registered” and “registering” shall have correlative meanings. 

“Registration Expenses” shall have the meaning set forth in Section 3.8. 

“Registration Statement” means any registration statement of the Company filed with, or to be filed with, the SEC under the
Securities Act, including the related Prospectus, amendments and supplements to such registration statement, including pre- and post-effective amendments, and all exhibits and all material incorporated by
reference in such registration statement other than a registration statement (and related Prospectus) filed on Form S-4 or Form S-8 or any successor form thereto. 

“Representatives” means, with respect to any Person, any of such Person’s officers, directors, employees, agents,
attorneys, accountants, actuaries, consultants, equity financing partners or financial advisors or other Person associated with, or acting on behalf of, such Person. 

“Requisite Investor Approval” means the prior written consent of the Requisite Investors. 

“Requisite Investors” means the holders of a majority of the Registrable Securities then held by the Investors.  
 “Rule 144” means Rule 144 under the Securities Act (or any successor
rule). 
 “SEC” means the Securities and Exchange Commission or any successor agency having jurisdiction under the
Securities Act. 
 “Securities Act” means the Securities Act of 1933, as amended, and any successor thereto, and any rules
and regulations promulgated thereunder, all as the same shall be in effect from time to time. 

  
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 “Selling Expenses” means all underwriting discounts, selling commissions, and
stock transfer taxes applicable to the sale of Registrable Securities, and fees and disbursements of counsel for any Holder (other than the fees and disbursements of the Selling Holder Counsel borne and paid by the Company as provided in
Section 3.8). 
 “Shelf Period” shall have the meaning set forth in Section 3.2.3. 

“Shelf Registration” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Registration Notice” shall have the meaning set forth in Section 3.2.2. 

“Shelf Registration Request” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Registration Statement” shall have the meaning set forth in Section 3.2.1(a). 

“Shelf Suspension” shall have the meaning set forth in Section 3.2.4. 

“Shelf Takedown Notice” shall have the meaning set forth in Section 3.2.5(b). 

“Shelf Takedown Request” shall have the meaning set forth in Section 3.2.5(a). 

“Transfer” means, with respect to any Registrable Security, any interest therein, or any other securities or equity interests
relating thereto, a direct or indirect transfer, sale, exchange, assignment, pledge, hypothecation or other encumbrance or other disposition thereof, including the grant of an option or other right, whether directly or indirectly, whether
voluntarily, involuntarily, by operation of law, pursuant to judicial process or otherwise. “Transferred” shall have a correlative meaning. 

“Underwritten Public Offering” means an underwritten Public Offering, including any bought deal or block sale to a financial
institution conducted as an underwritten Public Offering, in which the aggregate offering price, net of underwriting discounts and commissions but before expenses, of the Registrable Securities to be offered is at least $10,000,000. 

“Underwritten Shelf Takedown” means an Underwritten Public Offering pursuant to an effective Shelf Registration Statement.

 “WKSI” means any Securities Act registrant that is a well-known seasoned issuer as defined in Rule 405 under the
Securities Act at the most recent eligibility determination date specified in paragraph (2) of that definition. 
 Section 2.2.
Other Interpretive Provisions. (a) The meanings of defined terms are equally applicable to the singular and plural forms of the defined terms. 

(b) The words “hereof”, “herein”, “hereunder” and similar words refer to this Agreement as a whole and not to any
particular provision of this Agreement; and any subsection and section references are to this Agreement unless otherwise specified. 
 (c)
The term “including” is not limiting and means “including without limitation.” 

  
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 (d) The captions and headings of this Agreement are for convenience of reference only and shall
not affect the interpretation of this Agreement. 
 (e) Whenever the context requires, any pronouns used herein shall include the
corresponding masculine, feminine or neuter forms. 
 ARTICLE III 

REGISTRATION RIGHTS 
 The
Company will perform and comply, and cause each of its subsidiaries to perform and comply, with such of the following provisions as are applicable to it. Each Holder will perform and comply with such of the following provisions as are applicable to
such Holder. 
 Section 3.1. Demand Registration. 

Section 3.1.1. Request for Demand Registration. 

 

	 	(a)	At any time and from time to time each Holder shall have the right to make up to two (2) written demands (a “Demand Registration Request”) that the Company file a Registration Statement on Form S-1 for Registration of all or part of the Registrable Securities that the Holders request to be registered. Any such Registration pursuant to a Demand Registration Request shall hereinafter be referred to as a
“Demand Registration.” 

  

	 	(b)	Each Demand Registration Request shall specify (x) the kind and aggregate amount of Registrable Securities to be registered, and (y) the intended method or methods of disposition thereof. 

 

	 	(c)	Subject to Section 3.1.2, upon receipt of a Demand Registration Request, the Company shall as promptly as practicable file a Registration Statement (a “Demand Registration Statement”) relating to
such Demand Registration (or amend an existing registration statement to allow the resale by holders of Registrable Securities), and use its commercially reasonable efforts to cause such Demand Registration Statement to be promptly declared
effective under the Securities Act. 

 Section 3.1.2. Limitations on Demand Registrations.

  

	 	(a)	The Company shall not be obligated to take any action to effect any Demand Registration (i) if a Demand Registration or Piggyback Registration was declared effective or an Underwritten Shelf Takedown was
consummated within the preceding ninety (90) days (unless otherwise consented to by the Company); (ii) after the Company has effected two (2) Demand Registrations pursuant to Section 3.1.1 (plus two (2) additional Demand
Registrations if requested by the Requisite Investors); (iii) if the aggregate offering price, net of underwriting discounts and commissions 

  
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but before expenses, of the Registrable Securities to be offered is less than $5,000,000; (iv) if the Holder proposes to dispose of shares of Registrable Securities that may be immediately
registered on Form S-3 pursuant to a request made pursuant to Section 3.2; or (v) if, within the preceding thirty (30) days of the delivery of such Demand Registration Request, the Company has
delivered a Piggyback Notice for a proposed Piggyback Registration and the Company is actively pursuing in good faith such Piggyback Registration. 

Section 3.1.3. Demand Notice. Promptly upon receipt of a Demand Registration Request pursuant to Section 3.1.1
(but in no event more than two (2) Business Days thereafter), the Company shall deliver a written notice (a “Demand Notice”) of any such Demand Registration Request to all other Holders and the Demand Notice shall offer each
such Holder the opportunity to include in the Demand Registration that number of Registrable Securities as each such Holder may request in writing. Subject to Section 3.1.7, the Company shall include in the Demand Registration all such
Registrable Securities with respect to which the Company has received written requests for inclusion therein within five (5) Business Days after the date that the Demand Notice was delivered. 

Section 3.1.4. Demand Withdrawal. Each Holder that has requested its Registrable Securities be included in a Demand
Registration pursuant to this Section 3.1 may withdraw all or any portion of its Registrable Securities included in a Demand Registration from such Demand Registration at any time prior to the effectiveness of the applicable Demand Registration
Statement. Upon receipt of a notice to such effect with respect to all of the Registrable Securities included in such Demand Registration, the Company shall cease all efforts to secure effectiveness of the applicable Demand Registration Statement.
If the initiating Holders elect not to pay the registration expenses therefor, such Demand Registration shall be counted as “effected” and the Holders shall forfeit their right to one Demand Registration Statement pursuant to
Section 3.1.2. 
 Section 3.1.5. Effective Registration. The Company shall use commercially
reasonable efforts to cause the Demand Registration Statement to become effective and remain effective for not less than one hundred eighty (180) days (or such shorter period as will terminate when all Registrable Securities covered by such
Demand Registration Statement have been sold or withdrawn), or, if such Demand Registration Statement relates to an Underwritten Public Offering, such longer period as in the opinion of counsel for the underwriter or underwriters a Prospectus is
required by law to be delivered in connection with sales of Registrable Securities by an underwriter or dealer. 

Section 3.1.6. Delay in Filing; Suspension of Registration. If the Company receives a Demand Registration
Request and the Company furnishes to the initiating Holders making such demand a copy of a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Board it would be materially detrimental to
the Company and its stockholders for such registration statement to either become effective or remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would 

  
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 (a) materially interfere with a significant acquisition, corporate reorganization, or other
similar transaction involving the Company; (b) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential; or (c) render the Company unable to comply with
requirements under the Securities Act or Exchange Act (an “Officer’s Certificate”), then the Company shall have the right to defer taking action with respect to such filing (a “Demand
Suspension”), and any time periods with respect to filing or effectiveness thereof shall be tolled correspondingly, for a period or periods of not more than an aggregate of sixty (60) days per calendar year after the request of the
initiating Holders is given; provided, however, that the Company shall not register any securities for its own account or that of any other stockholder during such period or periods (except for any securities so registered pursuant to
Section 3.3.1(ii) and (iii) hereof). In the case of a Demand Suspension, the Holders agree to suspend use of the applicable Prospectus in connection with any sale or purchase, or offer to sell or purchase, Registrable Securities, upon receipt
of the notice referred to above. The Company shall immediately notify the Holders in writing upon the termination of any Demand Suspension, amend or supplement the Prospectus, if necessary, and furnish to the Holders such numbers of copies of the
Prospectus as so amended or supplemented as the Holders may reasonably request. The Company shall, if necessary, supplement or amend the Demand Registration Statement, if required by the registration form used by the Company for the Demand
Registration or by the instructions applicable to such registration form or by the Securities Act or the rules or regulations promulgated thereunder. 

Section 3.1.7. Priority of Securities Registered Pursuant to Demand Registrations. If the managing
underwriter or underwriters of a proposed Underwritten Public Offering of the Registrable Securities included in a Demand Registration advise the Company in writing that, in its or their opinion, that marketing factors (including potential impact on
the price, timing or distribution of the securities offered or the market for the securities offered) require a limitation on the number of shares to be underwritten, then the securities to be included in such Registration shall be, in the case of
any Demand Registration, (x) first, allocated to each Holder that has requested to participate in such Demand Registration an amount equal to the lesser of (i) the number of such Registrable Securities requested to be registered or sold by
such Holder, and (ii) a number of such shares equal to such Holder’s Pro Rata Portion, and (y) second, and only if all the securities referred to in clause (x) have been included, the number of other securities that, in the
opinion of such managing underwriter or underwriters can be sold without having such adverse effect. 
 Section 3.1.8.
Resale Rights. In the event that an Investor requests to participate in a Demand Registration pursuant to this Section 3.1 in connection with a distribution of Registrable Securities to its partners or members, the Registration shall
provide for resale by such partners or members, if requested by an Investor. 
 Section 3.2. Shelf Registration. 

Section 3.2.1. Request for Shelf Registration. 

  
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	 	(a)	Upon the written request of any Holder from time to time (a “Shelf Registration Request”), provided the Company is eligible to use a Registration Statement on Form
S-3 for transactions involving secondary offerings, the Company shall promptly file with the SEC a shelf Registration Statement pursuant to Rule 415 under the Securities Act (“Shelf Registration
Statement”) relating to the offer and sale of Registrable Securities by such Holder from time to time in accordance with the methods of distribution elected by such Holder, and the Company shall use its commercially reasonable efforts to
cause such Shelf Registration Statement to promptly become effective under the Securities Act. Any such Registration pursuant to a Shelf Registration Request shall hereinafter be referred to as a “Shelf Registration.” The Company
shall use its commercially reasonable efforts to qualify and remain qualified to register securities pursuant to a Registration Statement on Form S-3 (or any successor form) under the Securities Act.
Notwithstanding the above, the Company shall not be obligated to effect any Shelf Registration if the aggregate offering price, net of underwriting discounts and commissions but before expenses, of the Registrable Securities to be offered is less
than $5,000,000. 

  

	 	(b)	If on the date of the Shelf Registration Request the Company is a WKSI, then the Shelf Registration Request may request Registration of an unspecified amount of Registrable Securities to be sold by unspecified Holders.
If on the date of the Shelf Registration Request the Company is not a WKSI, then the Shelf Registration Request shall specify the aggregate amount of Registrable Securities to be registered. The Company shall provide to the Investors the information
necessary to determine the Company’s status as a WKSI upon request. 

 Section 3.2.2. Shelf
Registration Notice. Promptly upon receipt of a Shelf Registration Request (but in no event more than two (2) Business Days thereafter (or such shorter period as may be reasonably requested in connection with an underwritten “block
trade”)), the Company shall deliver a written notice (a “Shelf Registration Notice”) of any such request to all other Holders, which notice shall specify, if applicable, the amount of Registrable Securities to be registered,
and the Shelf Registration Notice shall offer each such Holder the opportunity to include in the Shelf Registration that number of Registrable Securities as each such Holder may request in writing. The Company shall include in such Shelf
Registration all such Registrable Securities with respect to which the Company has received written requests for inclusion therein within five (5) Business Days (or such shorter period as may be reasonably requested in connection with an
underwritten “block trade”) after the date that the Shelf Registration Notice has been delivered. 

Section 3.2.3. Continued Effectiveness. The Company shall use its commercially reasonable efforts to keep such
Shelf Registration Statement continuously effective under the Securities Act in order to permit the Prospectus forming part of the Shelf Registration Statement to be usable by Holders until the earlier of: (i) the date as of which all 

  
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 Registrable Securities have been sold pursuant to the Shelf Registration Statement or another
Registration Statement filed under the Securities Act (but in no event prior to the applicable period referred to in Section 4(a)(3) of the Securities Act and Rule 174 thereunder); and (ii) the date as of which no Holder holds Registrable
Securities (such period of effectiveness, the “Shelf Period”). Subject to Section 3.2.4, the Company shall be deemed not to have used its reasonable best efforts to keep the Shelf Registration Statement effective during the
Shelf Period if the Company voluntarily takes any action or omits to take any action that would result in Holders of the Registrable Securities covered thereby not being able to offer and sell any Registrable Securities pursuant to such Shelf
Registration Statement during the Shelf Period, unless such action or omission is required by applicable law. 

Section 3.2.4. Suspension of Registration. If the Company furnishes to Holders requesting a Shelf
Registration pursuant to this Section 3.2.1 an Officer’s Certificate, then the Company shall have the right to defer taking action with respect to such filing (a “Shelf Suspension”), and any time periods with respect to
filing or effectiveness thereof shall be tolled correspondingly, for a period or periods of not more than an aggregate of sixty (60) days per calendar year after the request of the initiating Holders is given, provided, however,
that the Company shall not register any securities for its own account or that of any other stockholder during such period or periods (except for any securities so registered pursuant to Section 3.3.1(ii) and (iii) hereof). In the case of a
Shelf Suspension, the Holders agree to suspend use of the applicable Prospectus in connection with any sale or purchase of, or offer to sell or purchase, Registrable Securities, upon receipt of the notice referred to above. The Company shall
immediately notify the Holders in writing upon the termination of any Shelf Suspension, amend or supplement the Prospectus, if necessary, and furnish to the Holders such numbers of copies of the Prospectus as so amended or supplemented as the
Holders may reasonably request. The Company shall, if necessary, supplement or amend the Shelf Registration Statement, if required by the registration form used by the Company for the Shelf Registration Statement or by the instructions applicable to
such registration form or by the Securities Act or the rules or regulations promulgated thereunder. 
 Section 3.2.5.
Shelf Takedown. 
  

	 	(a)	At any time the Company has an effective Shelf Registration Statement with respect to a Holder’s Registrable Securities, by notice to the Company specifying the intended method or methods of disposition thereof,
each Holder may make a written request (a “Shelf Takedown Request”) to the Company to effect a Public Offering, including an Underwritten Shelf Takedown, of all or a portion of such Holder’s Registrable Securities that may be
registered under such Shelf Registration Statement, and as soon as practicable the Company shall amend or supplement the Shelf Registration Statement as necessary for such purpose. 

  
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	 	(b)	Promptly upon receipt of a Shelf Takedown Request (but in no event more than two (2) Business Days thereafter (or such shorter period as may be reasonably requested in connection with an underwritten “block
trade”)) for any Underwritten Shelf Takedown, the Company shall deliver a notice (a “Shelf Takedown Notice”) to each other Holder with Registrable Securities covered by the applicable Registration Statement, or to all other
Holders if such Registration Statement is undesignated (each a “Potential Takedown Participant”). The Shelf Takedown Notice shall offer each such Potential Takedown Participant the opportunity to include in any Underwritten Shelf
Takedown such number of Registrable Securities as each such Potential Takedown Participant may request in writing. The Company shall include in the Underwritten Shelf Takedown all such Registrable Securities with respect to which the Company has
received written requests for inclusion therein within five (5) Business Days (or such shorter period as may be reasonably requested in connection with an underwritten “block trade”) after the date that the Shelf Takedown Notice has
been delivered. Notwithstanding the delivery of any Shelf Takedown Notice, all determinations as to whether to complete any Underwritten Shelf Takedown and as to the timing, manner, price and other terms of any Underwritten Shelf Takedown
contemplated by this Section 3.2.5 shall be determined by the Holders of a majority of the Registrable Securities proposed to be sold in such Underwritten Shelf Takedown. 

 

	 	(c)	The Company shall not be obligated to take any action to effect any Underwritten Shelf Takedown if a Demand Registration or Piggyback Registration was declared effective or an Underwritten Shelf Takedown was consummated
within the preceding ninety (90) days (unless otherwise consented to by the Company). 

Section 3.2.6. Priority of Securities Sold Pursuant to Shelf Takedowns. If the managing underwriter or underwriters
of a proposed Underwritten Shelf Takedown pursuant to Section 3.2.5 advise the Company in writing that, in its or their opinion, the number of securities requested to be included in the proposed Underwritten Shelf Takedown exceeds the number
that can be sold in such Underwritten Shelf Takedown without being likely to have an adverse effect on the price, timing or distribution of the securities offered or the market for the securities offered, the number of Registrable Securities to be
included in such offering shall be (x) first, allocated to each Holder that has requested to participate in such Underwritten Shelf Takedown an amount equal to the lesser of (i) the number of such Registrable Securities requested to be
registered or sold by such Holder, and (ii) a number of such shares equal to such Holder’s Pro Rata Portion, and (y) second, and only if all the securities referred to in clause (x) have been included, the number of other
securities that, in the opinion of such managing underwriter or underwriters, can be sold without having such adverse effect. 

Section 3.2.7. Resale Rights. In the event that an Investor elects to request a Shelf Registration pursuant to this
Section 3.2 in connection with a distribution of Registrable Securities to its partners or members, the Shelf Registration shall provide for resale by such partners or members, if requested by such Investor. 

  
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 Section 3.3. Piggyback Registration. 

Section 3.3.1. Participation. If the Company at any time proposes to file a Registration Statement under the
Securities Act or to conduct a Public Offering with respect to any offering of its equity securities for its own account or for the account of any other Persons (other than (i) a Registration under Section 3.1 or Section 3.2,
(ii) a Registration on Form S-4 or Form S-8 or any successor form to such forms or (iii) a Registration of securities solely relating to an offering and sale
to employees or directors of the Company or its subsidiaries pursuant to any employee stock plan or other employee benefit plan arrangement), then, as soon as practicable (but in no event less than ten (10) Business Days prior to the proposed
date of filing of such Registration Statement or, in the case of a Public Offering under a Shelf Registration Statement, the anticipated pricing or trade date), the Company shall give written notice (a “Piggyback Notice”) of such
proposed filing or Public Offering to all Holders, and such Piggyback Notice shall offer the Holders the opportunity to register under such Registration Statement, or to sell in such Public Offering, such number of Registrable Securities as each
such Holder may request in writing (any such Public Offering in which Holders participate, a “Piggyback Registration”). Subject to Section 3.3.2, the Company shall include in such Registration Statement or in such Public
Offering, as applicable, all such Registrable Securities that are requested to be included therein within five (5) Business Days after the receipt by such Holder of any such notice; provided, however, that if at any time after
giving written notice of its intention to register or sell any securities and prior to the effective date of the Registration Statement filed in connection with such Registration, or the pricing or trade date of a Public Offering under a Shelf
Registration Statement, the Company determines for any reason not to register or sell or to delay the Registration or sale of such securities, the Company shall give written notice of such determination to each Holder and, thereupon, (i) in the
case of a determination not to register or sell, shall be relieved of its obligation to register or sell any Registrable Securities in connection with such Registration or Public Offering (but not from its obligation to pay the Registration Expenses
in connection therewith), without prejudice, however, to the rights of any Holders entitled to request that such Registration or sale be effected as a Demand Registration under Section 3.1 or an Underwritten Shelf Takedown under
Section 3.2, as the case may be, and (ii) in the case of a determination to delay Registration or sale, in the absence of a request for a Demand Registration or an Underwritten Shelf Takedown, as the case may be, shall be permitted to
delay registering or selling any Registrable Securities for the same period as the delay in registering or selling such other securities. Any Holder shall have the right to withdraw all or part of its request for inclusion of its Registrable
Securities in a Piggyback Registration by giving written notice to the Company of its request to withdraw. 

Section 3.3.2. Priority of Piggyback Registration. If the managing underwriter or underwriters of any
proposed offering of Registrable Securities included in a Piggyback Registration informs the Company and the participating Holders in writing that, in its or their opinion, marketing factors (including potential impact on the price, timing or
distribution of the securities offered or the market for the securities offered) require a limitation on the number of shares to be underwritten, then the securities to be included in such Registration shall be (i) first, one hundred percent
(100%) of the securities that the 

  
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 Company proposes to sell, and (ii) second, and only if all the securities referred to in
clause (i) have been included, the number of Registrable Securities that, in the opinion of such managing underwriter or underwriters, can be sold without having such adverse effect, with such number to be allocated among the Holders that have
requested to participate in such Registration based on an amount equal to the lesser of (x) the number of such Registrable Securities requested to be sold by such Holder, and (y) a number of such shares equal to such Holder’s Pro Rata
Portion, and (iii) third, and only if all of the Registrable Securities referred to in clause (ii) have been included in such Registration, any other securities eligible for inclusion in such Registration. Notwithstanding the foregoing, no
such reduction shall reduce the value of the Registrable Securities of the Holders included in such registration below twenty-five percent (25)% of the total value of securities included in such registration. 

Section 3.3.3. No Effect on Other Registrations. No Registration of Registrable Securities effected pursuant to a
request under this Section 3.3 shall be deemed to have been effected pursuant to Section 3.1 or Section 3.2 or shall relieve the Company of its obligations under Section 3.1 and Section 3.2 unless all Registrable Securities
have been sold pursuant to such Registration Statement or another Registration Statement filed under the Securities Act. 

Section 3.4. Lock-Up Agreements. In connection with each Registration or sale of
Registrable Securities pursuant to Section 3.1, Section 3.2 or Section 3.3 conducted as an Underwritten Public Offering, each Holder selling Registrable Securities in such Underwritten Public Offering agrees, if requested, to become
bound by and to execute and deliver a lock-up agreement with the underwriter(s) of such Underwritten Public Offering restricting such Holder’s right to (a) Transfer, directly or indirectly, any
equity securities or securities convertible into or exercisable or exchangeable for equity securities of the Company held by such Holder or (b) enter into any swap or other arrangement that transfers to another any of the economic consequences
of ownership of such securities during the period commencing on the date of the final Prospectus relating to the Underwritten Public Offering and ending on the date specified by the underwriters (such period not to exceed ninety (90) days). The
terms of such lock-up agreements shall be negotiated among the Holders requested to execute and deliver such agreements, the Company and the underwriters and shall include customary carve-outs from the
restrictions on Transfer set forth therein. 
 Section 3.5.  Registration Procedures. 

Section 3.5.1. Requirements. In connection with the Company’s obligations under Section 3.1,
Section 3.2 and Section 3.3, the Company shall use its commercially reasonable efforts to effect such Registration and to permit the sale of such Registrable Securities in accordance with the intended method or methods of distribution
thereof as expeditiously as reasonably practicable, and in connection therewith the Company shall: 
  

	 	(a)	as promptly as practicable prepare the required Registration Statement, including all exhibits and financial statements required under the Securities Act to be filed therewith, and Prospectus, and, before filing a
Registration Statement or Prospectus or any amendments or supplements 

  
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	 	thereto, (x) furnish to the underwriters, if any, and to the Holders with Registrable Securities covered by such Registration Statement, copies of all documents prepared to be filed, which documents shall be
subject to the reasonable review of such underwriters and such Holders and their respective counsel, (y) make such changes in such documents concerning the Holders prior to the filing thereof as such Holders, or their counsel, may reasonably
request and (z) otherwise provide the Holders (to the extent participating in such registration) reasonable opportunity to comment on the registration statement, prospectus or any amendments or supplements thereto; 

 

	 	(b)	prepare and file with the SEC such amendments and post-effective amendments to such Registration Statement and supplements to the Prospectus as may be (x) reasonably requested by any Holder with Registrable
Securities covered by such Registration Statement (to the extent such request relates to information relating to such Holder), or (y) necessary to keep such Registration Statement effective for the period of time required by this Agreement, and
comply with provisions of the applicable securities laws with respect to the sale or other disposition of all securities covered by such Registration Statement during such period in accordance with the intended method or methods of disposition by
the sellers thereof set forth in such Registration Statement; 

  

	 	(c)	notify the Holders with Registrable Securities covered by the applicable Registration Statement and the managing underwriter or underwriters, if any, and (if requested) confirm such notice in writing and provide copies
of the relevant documents, as soon as reasonably practicable after notice thereof is received by the Company (a) when the applicable Registration Statement or any amendment thereto has been filed or becomes effective, and when the applicable
Prospectus or any amendment or supplement thereto has been filed, (b) of any written comments by the SEC, or any request by the SEC or other federal or state governmental authority for amendments or supplements to such Registration Statement or
such Prospectus, or for additional information (whether before or after the effective date of the Registration Statement) or any other correspondence with the SEC relating to, or which may affect, the Registration, (c) of the issuance by the
SEC of any stop order suspending the effectiveness of such Registration Statement or any order by the SEC or any other regulatory authority preventing or suspending the use of any preliminary or final Prospectus or the initiation or threatening of
any proceedings for such purposes, and (d) of the receipt by the Company of any notification with respect to the suspension of the qualification of the Registrable Securities for offering or sale in any jurisdiction or the initiation or
threatening of any proceeding for such purpose; 

  
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	 	(d)	promptly notify each Holder with Registrable Securities covered by the applicable Registration Statement and the managing underwriter or underwriters, if any, when the Company becomes aware of the happening of any event
as a result of which it shall be necessary to amend or supplement such Registration Statement or Prospectus in order to comply with the Securities Act and, as promptly as reasonably practicable thereafter, prepare and file with the SEC, and furnish
without charge to the Holders and the managing underwriter or underwriters, if any, an amendment or supplement to such Registration Statement or Prospectus, which shall effect such compliance; 

 

	 	(e)	to the extent the Company is eligible under the relevant provisions of Rule 430B under the Securities Act, if the Company files any Shelf Registration Statement and if requested by a Holder, the Company shall include in
such Shelf Registration Statement such disclosures as may be required by Rule 430B under the Securities Act (referring to the unnamed selling security holders in a generic manner by identifying the initial offering of the securities to such Holder)
in order to ensure that such Holder may be added to such Shelf Registration Statement at a later time through the filing of a Prospectus supplement rather than a post-effective amendment; 

 

	 	(f)	prevent, or obtain the withdrawal of, any stop order or other order or notice preventing or suspending the use of any preliminary or final Prospectus; 

 

	 	(g)	promptly incorporate in a Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment such information as the managing underwriter or underwriters and the participating Holders, or their respective
counsel, agree should be included therein relating to the plan of distribution with respect to such Registrable Securities; and make all required filings of such Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment as
soon as reasonably practicable after being notified of the matters to be incorporated in such Prospectus supplement, Issuer Free Writing Prospectus or post-effective amendment; 

 

	 	(h)	furnish to each Holder with Registrable Securities covered by the applicable Registration Statement and each underwriter, if any, without charge, as many conformed copies as such Holder or underwriter may reasonably
request of the applicable Registration Statement and any amendment or post-effective amendment or supplement thereto, including financial statements and schedules, all documents incorporated therein by reference and all exhibits (including those
incorporated by reference); 

  

	 	(i)	deliver to each Holder with Registrable Securities covered by the applicable Registration Statement and each underwriter, if any, without charge, as many copies of the applicable Prospectus (including each preliminary
Prospectus) and any amendment or supplement thereto and such other documents as such Holder or underwriter may reasonably request in order to facilitate the disposition of the Registrable Securities by 

  
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	 	such Holder or underwriter (it being understood that the Company shall consent to the use of such Prospectus or any amendment or supplement thereto by each such Holder and underwriter in connection with the offering and
sale of the Registrable Securities covered by such Prospectus or any amendment or supplement thereto); 

  

	 	(j)	on or prior to the date on which the applicable Registration Statement becomes effective, use its commercially reasonable efforts to register or qualify, and cooperate with the Holders with Registrable Securities
covered by such Registration Statement, the managing underwriter or underwriters, if any, and their respective counsel, in connection with the Registration or qualification of such Registrable Securities for offer and sale under the securities or
“Blue Sky” laws of each state and other jurisdiction as any such Holder or managing underwriter or underwriters, if any, or their respective counsel reasonably request in writing and do any and all other acts or things reasonably necessary
or advisable to keep such Registration or qualification in effect for such period as required by Section 3.1 or Section 3.2, as applicable, provided that the Company shall not be required to qualify generally to do business in any
jurisdiction where it is not then so qualified or to take any action which would subject it to taxation or general service of process in any such jurisdiction where it is not then so subject; 

 

	 	(k)	cooperate with the Holders with Registrable Securities covered by the applicable Registration Statement and the managing underwriter or underwriters, if any, to facilitate the timely preparation and delivery of
certificates representing Registrable Securities to be sold and not bearing any restrictive legends and enable such Registrable Securities to be in such denominations and registered in such names as the managing underwriters may request prior to any
sale of Registrable Securities to the underwriters; 

  

	 	(l)	cause the Registrable Securities covered by the applicable Registration Statement to be registered with or approved by such other governmental agencies or authorities as may be necessary to enable the seller or sellers
thereof or the underwriter or underwriters, if any, to consummate the disposition of such Registrable Securities; 

  

	 	(m)	make such representations and warranties to the Holders with Registrable Securities covered by the applicable Registration Statement and the underwriters or agents, if any, in form, substance and scope as are
customarily made by issuers in public offerings similar to the offering then being undertaken; 

  

	 	(n)	enter into such customary agreements (including underwriting and indemnification agreements) and take all such other actions as the participating Holders or the managing underwriter or underwriters, if any, reasonably
request in order to expedite or facilitate the Registration and disposition of such Registrable Securities; 

  
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	 	(o)	obtain for delivery to the Holders with Registrable Securities covered by the applicable Registration Statement and to the underwriter or underwriters, if any, an opinion or opinions from counsel for the Company dated
the most recent effective date of the Registration Statement or, in the event of an Underwritten Public Offering, the date of the closing under the underwriting agreement, in customary form, scope and substance, which opinions shall be reasonably
satisfactory to such Holders or underwriters, as the case may be, and their respective counsel; 

  

	 	(p)	in the case of an Underwritten Public Offering, obtain for delivery to the Company and the managing underwriter or underwriters, with copies to the Holders included in such Underwritten Public Offering, a comfort letter
from the Company’s independent certified public accountants or independent auditors (and, if necessary, any other independent certified public accountants or independent auditors of any subsidiary of the Company or any business acquired by the
Company for which financial statements and financial data are, or are required to be, included in the Registration Statement) in customary form and covering such matters of the type customarily covered by comfort letters as the managing underwriter
or underwriters reasonably request, dated the date of execution of the underwriting agreement and brought down to the closing under the underwriting agreement; 

  

	 	(q)	cooperate with each Holder with Registrable Securities covered by the applicable Registration Statement and each underwriter, if any, participating in the disposition of Registrable Securities and their respective
counsel in connection with any filings required to be made with FINRA; 

  

	 	(r)	comply with all applicable securities laws and, if a Registration Statement was filed, make available, including through the SEC’s EDGAR filing system or any successor system, to its security holders, as soon as
reasonably practicable, an earnings statement satisfying the provisions of Section 11(a) of the Securities Act and the rules and regulations promulgated thereunder; 

 

	 	(s)	provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by the applicable Registration Statement; 

 

	 	(t)	cause all Registrable Securities covered by the applicable Registration Statement to be listed on each securities exchange on which any of the Company’s equity securities are then listed or quoted and on each
inter-dealer quotation system on which any of the Company’s equity securities are then quoted; 

  
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	 	(u)	make available upon reasonable notice at reasonable times and for reasonable periods for inspection by a representative appointed by any underwriter participating in any disposition to be effected pursuant to a
Registration Statement and by any attorney, accountant or other agent retained by such underwriter, all pertinent financial and other records and pertinent corporate documents and properties of the Company, and cause all of the Company’s
officers, directors and employees and the independent public accountants who have certified its financial statements to make themselves available to discuss the business of the Company and to supply all information reasonably requested by any such
Person in connection with such Registration Statement; 

  

	 	(v)	in the case of an Underwritten Public Offering, cause the appropriate senior executive officers of the Company to participate in the customary “road show” presentations that may be reasonably requested by the
managing underwriter or underwriters in any such Underwritten Public Offering and otherwise to facilitate, cooperate with, and participate in each proposed offering contemplated herein and customary selling efforts related thereto;

  

	 	(w)	take no direct or indirect action prohibited by Regulation M under the Exchange Act; 

  

	 	(x)	take all reasonable action to ensure that any Issuer Free Writing Prospectus utilized in connection with any Registration complies in all material respects with the Securities Act, is filed in accordance with the
Securities Act to the extent required thereby, is retained in accordance with the Securities Act to the extent required thereby and, when taken together with the related Prospectus, will not contain any untrue statement of a material fact or omit to
state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading; and 

  

	 	(y)	take all such other commercially reasonable actions as are necessary or advisable in order to expedite or facilitate the disposition of such Registrable Securities in accordance with the terms of this Agreement.

 Section 3.5.2. Company Information Requests. The Company may require each Holder of Registrable
Securities as to which any Registration or sale is being effected to furnish to the Company such information regarding the distribution of such securities and such other information relating to such Holder and its ownership of Registrable Securities
as the Company may from time to time reasonably request in writing and the Company may exclude from such Registration or sale the Registrable Securities of any such Holder who unreasonably fails to furnish such information within a reasonable time
after receiving such request. Each Holder agrees to furnish such information to the Company and to cooperate with the Company as reasonably necessary to enable the Company to comply with the provisions of this Agreement. 

  
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 Section 3.5.3. Discontinuing Registration. Each Holder agrees that,
upon receipt of any notice from the Company of the happening of any event of the kind described in Section 3.5.1(d), such Holder will discontinue disposition of Registrable Securities pursuant to such Registration Statement until such Holder’s
receipt of the copies of the supplemented or amended Prospectus contemplated by Section 3.5.1(d), or until such Holder is advised in writing by the Company that the use of the Prospectus may be resumed, and has received copies of any additional or
supplemental filings that are incorporated by reference in the Prospectus, or any amendments or supplements thereto, and if so directed by the Company, such Holder shall deliver to the Company (at the Company’s expense) all copies, other than
permanent file copies then in such Holder’s possession, of the Prospectus covering such Registrable Securities current at the time of receipt of such notice. In the event the Company shall give any such notice, the period during which the
applicable Registration Statement is required to be maintained effective shall be extended by the number of days during the period from and including the date of the giving of such notice to and including the date when each seller of Registrable
Securities covered by such Registration Statement either receives the copies of the supplemented or amended Prospectus contemplated by Section 3.5.1(d) or is advised in writing by the Company that the use of the Prospectus may be resumed. 

Section 3.6.    Underwritten Offerings. 

Section 3.6.1. Shelf and Demand Registrations. If requested by the underwriters for any Underwritten Public
Offering, pursuant to a Registration or sale under Section 3.1 or Section 3.2, the Company shall enter into an underwriting agreement with such underwriters, such agreement to be reasonably satisfactory in substance and form to each of the
Company, the participating Holders and the underwriters, and to contain such representations and warranties by the Company and such other terms as are generally prevailing in agreements of that type, including indemnities no less favorable to the
recipient thereof than those provided in Section 3.9. The Holders of the Registrable Securities proposed to be distributed by such underwriters shall cooperate with the Company in the negotiation of the underwriting agreement and shall give
consideration to the reasonable suggestions of the Company regarding the form thereof, and such Holders shall complete and execute all questionnaires, powers of attorney and other documents reasonably requested by the underwriters and required under
the terms of such underwriting arrangements. Any such Holder shall not be required to make any representations or warranties to or agreements with the Company or the underwriters other than representations, warranties or agreements regarding such
Holder, such Holder’s title to the Registrable Securities, such Holder’s intended method of distribution and any other representations to be made by the Holder as are generally prevailing in agreements of that type, and the aggregate
amount of the liability of such Holder under such agreement shall not exceed such Holder’s proceeds from the sale of its Registrable Securities in the offering, net of underwriting discounts and commissions but before expenses. 

  
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 Section 3.6.2. Piggyback Registrations. If the Company proposes to
register or sell any of its securities under the Securities Act as contemplated by Section 3.3 and such securities are to be distributed through one or more underwriters, the Company shall, if requested by any Holder pursuant to
Section 3.3 and, subject to the provisions of Section 3.3.2, use its commercially reasonable efforts to arrange for such underwriters to include on the same terms and conditions that apply to the other sellers in such Registration or sale
all the Registrable Securities to be offered and sold by such Holder among the securities of the Company to be distributed by such underwriters in such Registration or sale. The Holders of Registrable Securities to be distributed by such
underwriters shall be parties to the underwriting agreement between the Company and such underwriters and shall complete and execute all questionnaires, powers of attorney and other documents reasonably requested by the underwriters and required
under the terms of such underwriting arrangements. Any such Holder shall not be required to make any representations or warranties to or agreements with the Company or the underwriters other than representations, warranties or agreements regarding
such Holder, such Holder’s title to the Registrable Securities, such Holder’s intended method of distribution and any other representations to be made by the Holder as are generally prevailing in agreements of that type, and the aggregate
amount of the liability of such Holder shall not exceed such Holder’s proceeds from the sale of its Registrable Securities in the offering, net of underwriting discounts and commissions but before expenses. 

Section 3.6.3. Selection of Underwriters; Selection of Counsel. In the case of an Underwritten Public Offering
under Section 3.1, Section 3.2 or Section 3.3, the managing underwriter or underwriters to administer the offering shall be selected by the Company and shall be reasonably acceptable to the Holders of a majority of the Registrable
Securities proposed to be sold; provided, however, that if such Underwritten Public Offering is conducted as an underwritten “block trade” initiated by a Holder or Holders, the potential underwriters from whom indications of
interest are solicited shall be mutually acceptable to the Company and the Holders of a majority of the Registrable Securities to be sold and the actual underwriter or underwriters shall be selected by the Holders of a majority of the Registrable
Securities proposed to be sold. In the case of an Underwritten Public Offering under Section 3.1, Section 3.2 or Section 3.3, counsel to the Holders shall be selected by the Holders of a majority of the Registrable Securities proposed
to be sold. 
 Section 3.7. No Inconsistent Agreements; Additional Rights. Neither the Company nor any of its subsidiaries shall
hereafter enter into, and neither the Company nor any of its subsidiaries is currently a party to, any agreement with respect to its securities that is inconsistent with the rights granted to the Holders by this Agreement, and that this Agreement
supersedes and replaces the Existing Registration Rights Agreement. Without Requisite Investor Approval, neither the Company nor any of its subsidiaries shall enter into any agreement granting registration or similar rights to any Person, and the
Company hereby represents and warrants that, as of the date hereof, no registration or similar rights have been granted to any other Person other than pursuant to this Agreement. 

Section 3.8. Registration Expenses. All expenses incident to the Company’s performance of or compliance with this Agreement
shall be paid by the Company, including (i) all registration and filing fees, and any other fees and expenses associated with filings required to be made with the SEC or FINRA, (ii) all fees and expenses in connection with compliance with
any securities or “Blue Sky” laws pursuant to Section 3.5.1(j) (including 

  
 -20- 

 reasonable fees and disbursements of counsel for the underwriters in connection with blue sky qualifications of
the Registrable Securities), (iii) all printing, duplicating, word processing, messenger, telephone, facsimile and delivery expenses (including expenses of printing certificates for the Registrable Securities in a form eligible for deposit with
The Depository Trust Company and of printing Prospectuses), (iv) all fees and disbursements of counsel for the Company and of all independent certified public accountants or independent auditors of the Company and any subsidiaries of the
Company (including the expenses of any special audit and comfort letters required by or incident to such performance), (v) Securities Act liability insurance or similar insurance if the Company so desires or the underwriters so require in
accordance with then-customary underwriting practice, (vi) all fees and expenses incurred in connection with the listing of the Registrable Securities on any securities exchange or quotation of the Registrable Securities on any inter-dealer
quotation system, (viii) all reasonable fees and disbursements for one legal counsel for the Holders with Registrable Securities covered by any Registration Statement (“Selling Holders Counsel”), (ix) any reasonable
disbursements of underwriters customarily paid by issuers, (x) all fees and expenses of any special experts or other Persons retained by the Company in connection with any Registration or sale, (xi) all of the Company’s internal
expenses (including all salaries and expenses of its officers and employees performing legal or accounting duties) and (xii) all Company expenses related to the “road show” for any Underwritten Public Offering. All such expenses are
referred to herein as “Registration Expenses”. The Company shall not be required to pay any fees and disbursements to underwriters not customarily paid by the issuers of securities in an offering similar to the applicable offering,
including Selling Expenses. 
 Section 3.9. Indemnification. 

Section 3.9.1. Indemnification by the Company. The Company shall indemnify and hold harmless, to the full
extent permitted by law, each Holder, each shareholder, member, limited or general partner of such Holder, each shareholder, member, limited or general partner of each such shareholder, member, limited or general partner, each of their respective
Affiliates, officers, directors, shareholders, employees, and agents and each Person who controls (within the meaning of the Securities Act or the Exchange Act) such Persons and each of their respective Representatives from and against any and all
losses, penalties, judgments, suits, costs, claims, damages, liabilities and expenses, joint or several (including reasonable costs of investigation and legal expenses ) (each, a “Loss” and collectively “Losses”)
arising out of or based upon (i) any untrue or alleged untrue statement of a material fact contained in any Registration Statement under which such Registrable Securities are registered or sold under the Securities Act (including any final,
preliminary or summary Prospectus contained therein or any amendment thereof or supplement thereto or any documents incorporated by reference therein) or any other disclosure document produced by or on behalf of the Company or any of its
subsidiaries including any report and other document filed under the Exchange Act, (ii) any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein (in the case of
a Prospectus or preliminary Prospectus, in light of the circumstances under which they were made) not misleading or (iii) any violation by the Company of the Securities Act, any state securities or “blue sky” laws or any rule or
regulation thereunder in connection with such registration; provided, that no Holder shall be entitled to indemnification pursuant to this Section 3.9.1 in respect 

  
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 of any untrue statement or omission contained in any information relating to such Holder
furnished in writing by such Holder to the Company specifically for inclusion in a Registration Statement and used by the Company in conformity therewith (such information “Selling Stockholder Information”). This indemnity shall be
in addition to any liability the Company may otherwise have. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of such Holder or any indemnified party and shall survive the Transfer of such
securities by such Holder and regardless of any indemnity agreed to in the underwriting agreement that is less favorable to the Holders. The Company shall also indemnify underwriters, selling brokers, dealer managers and similar securities industry
professionals participating in the distribution, their officers and directors and each Person who controls such Persons (within the meaning of the Securities Act and the Exchange Act) to the same extent as provided above (with appropriate
modification) with respect to the indemnification of the indemnified parties. 
 Section 3.9.2. Indemnification by
the Selling Holders. Each Holder with Registrable Securities covered by any Registration Statement agrees (severally and not jointly) to indemnify and hold harmless, to the fullest extent permitted by law, the Company, its directors and officers
and each Person who controls the Company (within the meaning of the Securities Act or the Exchange Act) from and against any Losses resulting from (i) any untrue statement of a material fact in any Registration Statement under which such
Registrable Securities were registered or sold under the Securities Act (including any final, preliminary or summary Prospectus contained therein or any amendment thereof or supplement thereto or any documents incorporated by reference therein) or
(ii) any omission to state therein a material fact required to be stated therein or necessary to make the statements therein (in the case of a Prospectus or preliminary Prospectus, in light of the circumstances under which they were made) not
misleading, in each case to the extent, but only to the extent, that such untrue statement or omission is contained in such Holder’s Selling Stockholder Information. In no event shall the liability of any Holder hereunder be greater in amount
than the dollar amount of the proceeds from the sale of its Registrable Securities in the offering giving rise to such indemnification obligation, net of underwriting discounts and commissions but before expenses, less any amounts paid by such
Holder pursuant to Section 3.9.4 and any amounts paid by such Holder as a result of liabilities incurred under the underwriting agreement, if any, related to such sale. 

Section 3.9.3. Conduct of Indemnification Proceedings. Any Person entitled to indemnification hereunder shall
(i) give prompt written notice to the indemnifying party of any claim with respect to which it seeks indemnification (provided that any delay or failure to so notify the indemnifying party shall relieve the indemnifying party of its
obligations hereunder only to the extent, if at all, that it is actually and materially prejudiced by reason of such delay or failure) and (ii) permit such indemnifying party to assume the defense of such claim with counsel reasonably
satisfactory to the indemnified party; provided, however, that any Person entitled to indemnification hereunder shall have the right to select and employ separate counsel and to participate in the defense of such claim, but the fees
and expenses of such counsel shall be at the expense of such Person unless (i) the indemnifying party has agreed in writing to pay such fees or 

  
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 expenses, (ii) the indemnifying party shall have failed to assume the defense of such claim
within a reasonable time after receipt of notice of such claim from the Person entitled to indemnification hereunder and employ counsel reasonably satisfactory to such Person, (iii) the indemnified party has reasonably concluded (based upon
advice of its counsel) that there may be legal defenses available to it or other indemnified parties that are different from or in addition to those available to the indemnifying party, or (iv) in the reasonable judgment of any such Person
(based upon advice of its counsel) a conflict of interest may exist between such Person and the indemnifying party with respect to such claims (in which case, if the Person notifies the indemnifying party in writing that such Person elects to employ
separate counsel at the expense of the indemnifying party, the indemnifying party shall not have the right to assume the defense of such claim on behalf of such Person). If the indemnifying party assumes the defense, the indemnifying party shall not
have the right to settle such action without the consent of the indemnified party. No indemnifying party shall consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the
claimant or plaintiff to such indemnified party of an unconditional release from all liability in respect to such claim or litigation without the prior written consent of such indemnified party. If such defense is not assumed by the indemnifying
party, the indemnifying party will not be subject to any liability for any settlement made without its prior written consent, but such consent may not be unreasonably withheld. It is understood that the indemnifying party or parties shall not,
except as specifically set forth in this Section 3.9.3, in connection with any proceeding or related proceedings in the same jurisdiction, be liable for the reasonable fees, disbursements or other charges of more than one separate firm admitted
to practice in such jurisdiction at any one time unless (x) the employment of more than one counsel has been authorized in writing by the indemnifying party or parties, (y) an indemnified party has reasonably concluded (based on the advice
of counsel) that there may be legal defenses available to it that are different from or in addition to those available to the other indemnified parties or (z) a conflict or potential conflict exists or may exist (based upon advice of counsel to
an indemnified party) between such indemnified party and the other indemnified parties, in each of which cases the indemnifying party shall be obligated to pay the reasonable fees and expenses of such additional counsel or counsels. 

Section 3.9.4. Contribution. If for any reason the indemnification provided for in Section 3.9.1 and Section 3.9.2 is
unavailable to an indemnified party or insufficient in respect of any Losses referred to therein (other than as a result of exceptions or limitations on indemnification contained in Section 3.9.1 and Section 3.9.2), then the indemnifying party shall
contribute to the amount paid or payable by the indemnified party as a result of such Loss in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and the indemnified party or parties on the other
hand in connection with the acts, statements or omissions that resulted in such Losses, as well as any other relevant equitable considerations. In connection with any Registration Statement filed with the SEC by the Company, the relative fault of
the indemnifying party on the one hand and the indemnified party on the other hand shall be determined by reference to, among other things, whether any untrue or alleged untrue statement of a material fact or the omission or alleged omission to
state a material fact relates to information supplied by the indemnifying party or by the indemnified party and 

  
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 the parties’ relative intent, knowledge, access to information and opportunity to correct or
prevent such statement or omission. The parties hereto agree that it would not be just or equitable if contribution pursuant to this Section 3.9.4 were determined by pro rata allocation or by any other method of allocation that
does not take account of the equitable considerations referred to in this Section 3.9.4. No Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution
from any Person who was not guilty of such fraudulent misrepresentation. The amount paid or payable by an indemnified party as a result of the Losses referred to in Section 3.9.1 and Section 3.9.2 shall be deemed to include, subject to the
limitations set forth above, any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this Section 3.9.4, in connection
with any Registration Statement filed by the Company, a Holder with Registrable Securities covered by any such Registration Statement shall not be required to contribute any amount in excess of the dollar amount of the proceeds from the sale of its
Registrable Securities in the offering giving rise to such indemnification obligation, net of underwriting discounts and commissions but before expenses, less any amounts paid by such Holder pursuant to Section 3.9.2 and any amounts paid by
such Holder as a result of liabilities incurred under the underwriting agreement, if any, related to such sale. If indemnification is available under this Section 3.9, the indemnifying parties shall indemnify each indemnified party to the full
extent provided in Section 3.9.1 and Section 3.9.2 without regard to the provisions of this Section 3.9.4. The remedies provided for in this Section 3.9 are not exclusive and shall not limit any rights or remedies which may
otherwise be available to any indemnified party at law or in equity. 
 Section 3.9.5. Indemnification Priority.
The Company hereby acknowledges and agrees that any of the Persons entitled to indemnification pursuant to Section 3.9.1 (each, a “Company Indemnitee” and collectively, the “Company Indemnitees”)
may have certain rights to indemnification, advancement of expenses and/or insurance provided by other sources. The Company hereby acknowledges and agrees (i) that it is the indemnitor of first resort (i.e., its obligations to a Company
Indemnitee are primary and any obligation of such other sources to advance expenses or to provide indemnification for the same expenses or liabilities incurred by such Company Indemnitee are secondary) and (ii) that it shall be required to
advance the full amount of expenses incurred by a Company Indemnitee and shall be liable for the full amount of all expenses incurred by a Company Indemnitee and shall be liable for the full amount of all expenses, judgments, penalties, fines and
amounts paid in settlement to the extent legally permitted and as required by the terms of this Agreement without regard to any rights a Company Indemnitee may have against such other sources. The Company further agrees that no advancement or
payment by such other sources on behalf of a Company Indemnitee with respect to any claim for which such Company Indemnitee has sought indemnification, advancement of expenses or insurance from the Company shall affect the foregoing, and that such
other sources shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of such Company Indemnitee against the Company. 

  
 - 24 - 

 Section 3.10. SEC Filings; Rules 144 and 144A and Regulation S.
The Company shall file the reports required to be filed by it under the Securities Act and the Exchange Act and the rules and regulations adopted by the SEC thereunder (or, if the Company is not required to file such reports, it will, upon the
request of any Investor, make publicly available such necessary information for so long as necessary to permit sales that would otherwise be permitted by this Agreement pursuant to Rule 144, Rule 144A or Regulation S under the Securities Act, as
such rules may be amended from time to time or any similar rule or regulation hereafter adopted by the SEC), and it will take such further action as any Investor may reasonably request, all to the extent required from time to time to enable such
Investor to sell Registrable Securities pursuant to Form S-3 or without Registration under the Securities Act pursuant to Rule 144, Rule 144A or Regulation S under the Securities Act, as such rules may be
amended from time to time, or any similar rule or regulation hereafter adopted by the SEC. Upon the request of any Investor, the Company will deliver to such Investor a written statement as to whether it has complied with such requirements and, if
not, the specifics thereof. 
 Section 3.11. Existing Registration Statements. Notwithstanding anything herein to the
contrary and subject to applicable law and regulation, the Company may satisfy any obligation hereunder to file a Registration Statement or to have a Registration Statement become effective by a specified date by designating, by notice to the
Holders, a Registration Statement that previously has been filed with the SEC or become effective, as the case may be, as the relevant Registration Statement for purposes of satisfying such obligation, and all references to any such obligation shall
be construed accordingly; provided that such previously filed Registration Statement may be, and is, amended or, subject to applicable securities laws, supplemented to add the number of Registrable Securities, and, to the extent necessary, to
identify as selling stockholders those Holders demanding the filing of a Registration Statement pursuant to the terms of this Agreement. To the extent this Agreement refers to the filing or effectiveness of other Registration Statements, by or at a
specified time and the Company has, in lieu of then filing such Registration Statements or having such Registration Statements become effective, designated a previously filed or effective Registration Statement as the relevant Registration Statement
for such purposes, in accordance with the preceding sentence, such references shall be construed to refer to such designated Registration Statement, as amended or supplemented in the manner contemplated by the immediately preceding sentence. 

ARTICLE IV 

MISCELLANEOUS 

Section 4.1. Authority; Effect. Each party hereto represents and warrants to and agrees with each other party that the
execution and delivery of this Agreement and the consummation of the transactions contemplated hereby have been duly authorized on behalf of such party and do not violate any agreement or other instrument to which it is a party or by which its
assets are bound. This Agreement does not, and shall not be construed to, give rise to the creation of a partnership among any of the parties hereto, or to constitute any of such parties members of a joint venture or other association. The Company
and its subsidiaries shall be jointly and severally liable for all obligations of each such party pursuant to this Agreement. 

Section 4.2. Notices. Any notices, requests, demands and other communications required or permitted in this Agreement shall be
effective if in writing and (i) delivered personally, (ii) sent by facsimile or e-mail, or (iii) sent by overnight courier, in each case, addressed as follows: 

  
 - 25 - 

 If to the Company to: 

Dicerna Pharmaceuticals, Inc. 

87 Cambridgepark Drive 

Cambridge, MA 02140 

Attention:            Douglas Fambrough, President and Chief Executive Officer

 Facsimile:           (617) 612-6298 

E-mail:               
dfambrough@dicerna.com 
 and 

Attention:            Jack Green, Chief Financial Officer 

Facsimile:           (617) 612-6298 

E-mail:                
jackgreen@dicerna.com 
 with a copy (which shall not constitute notice) to: 

Sidley Austin LLP 
 1001 Page
Mill Road 
 Building 1 
 Palo
Alto, CA 94304 
 Attention:            Sam Zucker 

Facsimile:           (650) 565-6001 

E-mail:                
szucker@sidley.com 
 If to any Investor: 

To the address set forth below such party’s signature hereto; 

with a copy (which shall not constitute notice) to: 

Ropes & Gray LLP 

Prudential Tower 
 800 Boylston
Street 
 Boston, MA 02199 

Attention:            Michael D. Beauvais 

Facsimile:           (617) 235-0641 

E-mail:                
michael.beauvais@ropesgray.com 
 Notice to the holder of record of any Registrable Securities shall be deemed to be notice to the
holder of such securities for all purposes hereof. 
 Unless otherwise specified herein, such notices or other communications shall be
deemed effective (i) on the date received, if personally delivered, (ii) on the date received if delivered by facsimile or e-mail on a Business Day, or if not delivered on a Business Day, on the
first Business Day thereafter and (iii) two (2) Business Days after being sent by overnight courier. Each of the parties hereto shall be entitled to specify a different address by giving notice as aforesaid to each of the other parties hereto.

  
 - 26 - 

 Section 4.3. Termination and Effect of Termination. This Agreement shall terminate,
except for the provisions of Section 3.8, Section 3.9 and Section 3.10, which shall survive any such termination, upon the date that is the earliest to occur of (i) the date on which no Holder holds any Registrable Securities;
and (ii) the date on which the Company is no longer subject to the reporting requirements of Section 13 or 15(d) of the Exchange Act and is no longer otherwise required to report on an annual or quarterly basis on forms provided for such
annual or quarterly reporting pursuant to the rules and regulations promulgated by the SEC. No termination under this Agreement shall relieve any Person of liability for breach or Registration Expenses incurred prior to termination. In the
event this Agreement is terminated, each Person entitled to indemnification rights pursuant to Section 3.9 shall retain such indemnification rights with respect to any matter that (i) may be an indemnified liability thereunder and
(ii) occurred prior to such termination. 
 Section 4.4. Permitted Transferees. The rights of a Holder hereunder may be
assigned (but only with all related obligations as set forth below) in connection with a Transfer of Registrable Securities to a Permitted Transferee of that Holder. Without prejudice to any other or similar conditions imposed hereunder with respect
to any such Transfer, no assignment permitted under the terms of this Section 4.4 will be effective unless the Permitted Transferee to which the assignment is being made, if not a Holder, has delivered to the Company a written acknowledgment
and agreement in form and substance reasonably satisfactory to the Company that the Permitted Transferee will be bound by, and will be a party to, this Agreement. A Permitted Transferee to whom rights are transferred pursuant to this
Section 4.4 may not again transfer those rights to any other Permitted Transferee, other than as provided in this Section 4.4. 

Section 4.5. Remedies. The parties to this Agreement shall have all remedies available at law, in equity or otherwise in
the event of any breach or violation of this Agreement or any default hereunder. The parties acknowledge and agree that in the event of any breach of this Agreement, in addition to any other remedies that may be available, each of the parties hereto
shall be entitled to specific performance of the obligations of the other parties hereto and, in addition, to such other equitable remedies (including preliminary or temporary relief) as may be appropriate in the circumstances. No delay of or
omission in the exercise of any right, power or remedy accruing to any party as a result of any breach or default by any other party under this Agreement shall impair any such right, power or remedy, nor shall it be construed as a waiver of or
acquiescence in any such breach or default, or of any similar breach or default occurring later; nor shall any such delay, omission nor waiver of any single breach or default be deemed a waiver of any other breach or default occurring before or
after that waiver. 
 Section 4.6. Amendments. This Agreement may not be orally amended, modified, extended or terminated, nor
shall any oral waiver of any of its terms be effective. This Agreement may be amended, modified, extended or terminated, and the provisions hereof may be waived, only by an agreement in writing signed by the Company and the Requisite Investors;
provided, however, that any amendment, modification, extension or termination that disproportionately and adversely affects any Holder shall require the prior written consent of such Holder. Each such amendment, modification, extension
or termination shall be binding upon each party hereto and such Holder’s Permitted Transferees. In addition, each party hereto may waive any right hereunder by an instrument in writing signed by such party. 

  
 - 27 - 

 Section 4.7. Governing Law. This Agreement and all claims arising out of or based
upon this Agreement or relating to the subject matter hereof shall be governed by and construed in accordance with the domestic substantive laws of the State of New York without giving effect to any choice or conflict of laws provision or rule that
would cause the application of the domestic substantive laws of any other jurisdiction. 
 Section 4.8. Consent to Jurisdiction.
Each party to this Agreement, by its execution hereof, (i) hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the State of New York for the purpose of any action, claim, cause of action or suit
(in contract, tort or otherwise), inquiry, proceeding or investigation arising out of or based upon this Agreement or relating to the subject matter hereof, (ii) hereby waives to the extent not prohibited by applicable law, and agrees not to
assert, and agrees not to allow any of its subsidiaries to assert, by way of motion, as a defense or otherwise, in any such action, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is
exempt or immune from attachment or execution, that any such proceeding brought in one of the above-named courts is improper, or that this Agreement or the subject matter hereof or thereof may not be enforced in or by such court and
(iii) hereby agrees not to commence or maintain any action, claim, cause of action or suit (in contract, tort or otherwise), inquiry, proceeding or investigation arising out of or based upon this Agreement or relating to the subject matter
hereof or thereof other than before one of the above-named courts nor to make any motion or take any other action seeking or intending to cause the transfer or removal of any such action, claim, cause of action or suit (in contract, tort or
otherwise), inquiry, proceeding or investigation to any court other than one of the above-named courts whether on the grounds of inconvenient forum or otherwise. Notwithstanding the foregoing, to the extent that any party hereto is or becomes a
party in any litigation in connection with which it may assert indemnification rights set forth in this Agreement, the court in which such litigation is being heard shall be deemed to be included in clause (i) above. Notwithstanding the
foregoing, any party to this Agreement may commence and maintain an action to enforce a judgment of any of the above-named courts in any court of competent jurisdiction. Each party hereto hereby consents to service of process in any such proceeding
in any manner permitted by New York law, and agrees that service of process by registered or certified mail, return receipt requested, at its address specified pursuant to Section 4.2 is reasonably calculated to give actual notice. 

Section 4.9. WAIVER OF JURY TRIAL. TO THE EXTENT NOT PROHIBITED BY APPLICABLE LAW WHICH CANNOT BE WAIVED, EACH PARTY HERETO HEREBY
WAIVES AND COVENANTS THAT IT WILL NOT ASSERT (WHETHER AS PLAINTIFF, DEFENDANT OR OTHERWISE) ANY RIGHT TO TRIAL BY JURY IN ANY FORUM IN RESPECT OF ANY ISSUE OR ACTION, CLAIM, CAUSE OF ACTION OR SUIT (IN CONTRACT, TORT OR OTHERWISE), INQUIRY,
PROCEEDING OR INVESTIGATION ARISING OUT OF OR BASED UPON THIS AGREEMENT OR THE SUBJECT MATTER HEREOF OR IN ANY WAY CONNECTED WITH OR RELATED OR INCIDENTAL TO THE TRANSACTIONS CONTEMPLATED HEREBY, IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER
ARISING. EACH PARTY HERETO ACKNOWLEDGES THAT IT HAS BEEN INFORMED BY THE OTHER PARTIES HERETO 

  
 - 28 - 

 
THAT THIS SECTION 4.9 CONSTITUTES A MATERIAL INDUCEMENT UPON WHICH THEY ARE RELYING AND WILL RELY IN ENTERING INTO THIS AGREEMENT. ANY PARTY HERETO MAY FILE AN ORIGINAL COUNTERPART OR A COPY OF
THIS SECTION 4.9 WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT OF EACH SUCH PARTY TO THE WAIVER OF ITS RIGHT TO TRIAL BY JURY. 

Section 4.10. Merger; Binding Effect, Etc. This Agreement constitutes the entire agreement of the parties with respect to its
subject matter, supersedes all prior or contemporaneous oral or written agreements or discussions with respect to such subject matter, and shall be binding upon and inure to the benefit of the parties hereto and thereto and their respective heirs,
representatives, successors and permitted assigns. Except as otherwise expressly provided herein, no Holder or other party hereto may assign any of its respective rights or delegate any of its respective obligations under this Agreement without the
prior written consent of the other parties hereto, and any attempted assignment or delegation in violation of the foregoing shall be null and void. 

Section 4.11. Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original,
but all of which taken together shall constitute one instrument. 
 Section 4.12. Severability. In the event that any provision
hereof would, under applicable law, be invalid or unenforceable in any respect, such provision shall be construed by modifying or limiting it so as to be valid and enforceable to the maximum extent compatible with, and possible under, applicable
law. The provisions hereof are severable, and in the event any provision hereof should be held invalid or unenforceable in any respect, it shall not invalidate, render unenforceable or otherwise affect any other provision hereof. 

Section 4.13. No Recourse. Notwithstanding anything that may be expressed or implied in this Agreement, the Company and each
Holder covenant, agree and acknowledge that no recourse under this Agreement or any documents or instruments delivered in connection with this Agreement shall be had against any current or future director, officer, employee, general or limited
partner or member of any Holder or of any Affiliate or assignee thereof, as such, whether by the enforcement of any assessment or by any legal or equitable proceeding, or by virtue of any statute, regulation or other applicable law, it being
expressly agreed and acknowledged that no personal liability whatsoever shall attach to, be imposed on or otherwise be incurred by any current or future officer, agent or employee of any Holder or any current or future member of any Holder or any
current or future director, officer, employee, partner or member of any Holder or of any Affiliate or assignee thereof, as such, for any obligation of any Holder under this Agreement or any documents or instruments delivered in connection with this
Agreement for any claim based on, in respect of or by reason of such obligations or their creation. 
 [Signature pages follow] 

  
 - 29 - 

 IN WITNESS WHEREOF, each of the undersigned has duly executed this Agreement as of the
date first above written. 
  

					
	 Company:
	 	 DICERNA PHARMACEUTICALS, INC.

			
		 	By:	 	  

		 		 	 Name:
 Title:

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

							
	Investors:	 		 	Bain Capital Life Sciences Fund, L.P.
		 		 	 By: Bain Capital Life Sciences Partners, LP,

		 		 	 its general partner

		 		 	 By: Bain Capital Life Sciences Investors, LLC

		 		 	 its general partner

				
		 		 	 By:
	 	  

		 		 	 Name:

		 		 	 Title:

			
		 		 	 Address:

		 		 	 200 Clarendon Street

		 		 	 Boston, MA 02116

			
		 		 	BCIP Life Sciences Associates, LP
		 		 	 By: Boylston Coinvestors, LLC

		 		 	 its general partner

				
		 		 	 By:
	 	  

		 		 	 Name:

		 		 	 Title:

			
		 		 	 Address:

		 		 	 200 Clarendon Street

		 		 	 Boston, MA 02116

			
		 		 	Cormorant Private Healthcare Fund I, LP
		 		 	 By: Cormorant Private Healthcare GP, LLC,

		 		 	 its general partner

				
		 		 	 By:
	 	  

		 		 	 Name:

		 		 	 Title:

			
		 		 	 Address:

		 		 	 200 Clarendon Street, 52nd
Floor

		 		 	 Boston, MA 02116

			
		 		 	Cormorant Global Healthcare Master Fund, LP
		 		 	 By: Cormorant Global Healthcare GP, LLC,

		 		 	 its general partner

				
		 		 	 By:
	 	  

		 		 	 Name:

		 		 	 Title:

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 
			
	Address:
	200 Clarendon Street, 52nd Floor
	Boston, MA 02116
	
	CRMA SPV, L.P.
	 By: Cormorant Asset Management, LLC,

its Special Limited Partner

		
	By:	 	  

	Name:
	Title:
	
	Address:
	PO Box 309
	Ugland House, Grand Cayman
	KY1-1104, Cayman Islands
	
	Domain Partners VIII, L.P.
	 By: One Palmer Square Associates VIII,

LLC its general partner

		
	By:	 	  

	Name:
	Title:
	
	Address:
	One Palmer Square, Suite 515
	Princeton, NJ 08542
	
	DP VIII Associates, L.P.
	 By: One Palmer Square Associates VIII,

LLC its general partner

		
	By:	 	  

	Name:
	Title:
	
	Address:
	One Palmer Square, Suite 515
	Princeton, NJ 08542

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 
			
	 EcoR1 Capital Fund, L.P.

	By: EcoR1 Capital, LLC,
	its general partner
		
	By:	 	  

	Name:
	Title:
	
	Address:
	409 Illinois Street
	San Francisco, CA 94158
	
	EcoR1 Capital Fund Qualified, L.P.
	By: EcoR1 Capital, LLC,
	its general partner
		
	By:	 	  

	Name:
	Title:
	
	Address:
	409 Illinois Street
	San Francisco, CA 94158
	
	RA Capital Healthcare Fund, L.P.
	By: RA Capital Management, LLC,
	its general partner
		
	By:	 	  

	Name:
	Title:
	
	Address:
	20 Park Plaza, Suite 1200
	Boston, MA 02116

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 
			
	 Blackwell Partners LLC – Series A

		
	By:	 	  

	Name:
	Title: Authorized Signatory
		
	By:	 	  

	Name:
	Title: Authorized Signatory
	
	Address:
	280 S. Mangum Street, Suite 210
	Durham, NC 27701
	
	RTW Master Fund, LTD
		
	By:	 	  

	Name:
	Title:
	
	Address:
	250 West 55th Street, 16th Floor, Suite A
	New York, NY 10019
	
	RTW Innovation Master Fund, LTD
		
	By:	 	  

	Name:
	Title:
	
	Address:
	250 West 55th Street, 16th Floor, Suite A
	New York, NY 10019
	
	Skyline Venture Partners V, L.P.
	By: Skyline Venture Management V, LLC,
	its general partner
		
	By:	 	  

	Name:
	Title:
	
	Address:
	525 University Avenue, Suite 1350
	Palo Alto, CA 94301

  
 [Signature Page to
Amended and Restated Registration Rights Agreement]EX-10.3

 Exhibit 10.3 

, 2017 
 Dicerna Pharmaceuticals, Inc. 

87 Cambridgepark Drive 
 Cambridge, MA 02140 

 

	 	Re:	Bain Director Side Letter Agreement 

 Reference is made to (i) that certain
Redeemable Convertible Preferred Stock Purchase Agreement, dated as of March 30, 2017, by and among Dicerna Pharmaceuticals, Inc., a Delaware corporation (the “Company”), certain investment funds advised by Bain Capital Life
Sciences, LP (such funds, the “Bain Investors”) and the other investors party thereto (the “Stock Purchase Agreement”) pursuant to which, among other things, the Company agreed to expand the size of its board of
directors (the “Board”) by one director and appoint an individual nominated by the Bain Investors to fill the resulting vacancy; (ii) the appointment, on the date hereof, and pursuant to the Stock Purchase Agreement, of Adam
Koppel (the “Bain Director”) to the Board and (iii) that certain Indemnification Agreement, dated as of the date hereof (the “Indemnification Agreement”), by and between the Company and the Bain Director. The
Company and the Bain Director are collectively referred to hereinafter as the “Parties.” 
 In consideration of the
foregoing and the mutual covenants and agreements contained herein, and other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, and with the intention to be legally bound hereby, the Parties agree as
follows: 
  

	 	1.	 Indemnification Priority. Notwithstanding anything to the contrary in the Indemnification Agreement, the
Company hereby agrees that (i) it is the indemnitor of first resort under the Indemnification Agreement, this letter agreement and any other agreement or undertaking (whether pursuant to contract, bylaws or charter) by the Company pursuant to
which the Bain Director may assert a claim for indemnification or advancement; (ii) that the Company’s obligations to the Bain Director under the Indemnification Agreement, this letter agreement or any other agreement or undertaking
(whether pursuant to contract, bylaws or charter) to provide advancement and/or indemnification to the Bain Director are primary, and that any obligation of any Related Stockholder to provide advancement or indemnification (whether pursuant to
contract, bylaws or charter) are secondary; and (iii) any obligation of any insurer of any Related Stockholder to provide insurance coverage for any amounts indemnifiable or otherwise covered by the Indemnification Agreement, this letter
agreement or any other agreement or undertaking (whether pursuant to contract, bylaws or charter) by the Company to provide advancement and/or indemnification to the Bain Director is secondary to those advancement and indemnification obligations.
The Company hereby further agrees that if any Related Stockholder pays or causes to be paid, for any reason, any amounts otherwise properly indemnified or advanced under the Indemnification Agreement or under any other agreement or undertaking
(whether pursuant to contract, bylaws or 

	 	
charter) of the Company, then (x) such Related Stockholder shall be fully subrogated to all rights of the Bain Director with respect to such payment and (y) the Company shall fully
indemnify or otherwise reimburse such Related Stockholder for all such payments made by such Related Stockholder. For purposes of this Section 1, “Related Stockholder” shall mean the Bain Investors, including Bain Capital Life
Sciences Fund, L.P. and BCIP Life Sciences Associates, LP, and any related investment adviser or management company, any investment fund, managing member or general partner that is an affiliate of any of the foregoing entities or that is advised by
the same investment adviser as any of the foregoing entities or by an affiliate of such investment adviser (excluding, for the avoidance of doubt, the Company). 

  

	 	2.	Corporate Opportunity. The Parties agree that the provisions of Section 6.10 of the Stock Purchase Agreement shall apply to the Bain Director. The Parties agree that the Bain Director is an intended
third-party beneficiary of such provisions and is entitled to rely upon and enforce the rights and obligations granted therein. 

  

	 	3.	Miscellaneous. This letter agreement is a supplement to the Indemnification Agreement and is in furtherance of the Company’s Amended and Restated Certificate of Incorporation, the Company’s Amended and
Restated Bylaws, the laws of the State of Delaware and all other applicable law, and shall not be deemed a substitute thereof, nor to diminish or abrogate any rights of the Bain Director thereunder. The Parties agree that the provisions of this
letter agreement shall not be construed for or against any party hereto based on authorship. Sections 16, 18, 22, 23 and 24 of the Indemnification Agreement are hereby incorporated by reference in, and made applicable to, this letter agreement,
mutatis mutandis. 

 [Remainder of Page Intentionally Left Blank] 

  
 -2- 

 The parties hereto have executed this letter agreement as of the date first set forth above. 

 

			
	  

	Adam Koppel
	
	DICERNA PHARMACEUTICALS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	

 [Signature Page to Director Side Letter]

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