Document:

Exhibit 10.1

                             SUBSCRIPTION AGREEMENT

First Ipswich Bancorp
31 Market Street
Ipswich, Massachusetts 01938
Attn: Timothy L. Felter

      Re: Subscription for Shares of Common Stock of First Ipswich Bancorp

Ladies and Gentlemen:

I. Offering. The undersigned understands that First Ipswich Bancorp, a
Massachusetts chartered holding company headquartered in Ipswich, Massachusetts
(the "Company"), is offering to sell until March 31, 2007 an aggregate of up to
250,000 shares of its common stock, par value $1.00 per share ("Common Stock"),
at $8.00 per share, to a limited number of investors in accordance with the
terms and conditions described herein (the "Offering"). The minimum subscription
is for 6,250 shares of Common Stock (125 shares for Directors and Executive
Officers of the Company) unless the Company agrees to accept a lesser
subscription. As additional consideration for the undersigned's subscription for
shares of Common Stock hereunder (assuming the same is accepted by the Company),
the Company will issue to the undersigned for no additional consideration, a
Warrant in the form attached hereto as Exhibit A (the "Warrant") to purchase a
number of shares of Common Stock equal to 20% of the shares subscribed
hereunder. The Warrant will be exercisable from the date of issuance for three
years at a price equal to $8.00 per share, subject to the terms and conditions
described therein.

II. Use of Proceeds. The undersigned understands that The First National Bank of
Ipswich, the Company's wholly-owned subsidiary and a national bank (the "Bank"),
is subject to a Formal Agreement with The Office of the Comptroller of the
Currency, under which the Bank is required to achieve certain capital ratios by
December 31, 2006. The undersigned further understands that the proceeds from
this Offering will be used to help the Bank meet the capital ratios required by
the Formal Agreement, to cover costs and expenses associated with this Offering
and for general corporate purposes.

III. Purchase and Sale. Subject to the terms and conditions described herein,
the undersigned ("Purchaser") hereby irrevocably subscribes for and agrees to
purchase from the Company ________ shares ("Shares") of Common Stock at a
purchase price of $8.00 per Share for an aggregate purchase price of $_________.
This subscription may be rejected, in whole or in part, by the Company in its
sole discretion. Two executed copies of this Subscription Agreement must be
delivered to the Company no later than March 31, 2007.
<PAGE>

The Company presently intends to accept, in whole or in part, Subscription
Agreements delivered on or before January 26, 2007. The Company reserves the
right to terminate the Offering at any time, including, without limitation,
after January 26, 2007.

IV. Amount and Method of Payment. Purchaser hereby delivers to the Company (or
if the Subscription Agreement is delivered prior to January 26, 2007, agrees to
deliver to the Company on or before January 26, 2007) a check or money order
made payable to the order of "First Ipswich Bancorp" in the amount of the
aggregate purchase price indicated above (to be held in a deposit account at the
Bank in escrow). If a subscription is rejected in whole or in part or if the
Offering is terminated for any reason, Purchaser's subscription shall be void
and all funds received from Purchaser shall be returned as soon as practicable
to Purchaser without any interest thereon, and without charge or deduction.

V. Representations and Warranties of Purchaser. In order to induce the Company
to accept this subscription, Purchaser hereby represents and warrants to, and
covenants with, the Company as follows:

5.1 The undersigned understands that the Shares, the Warrant, and the shares of
Common Stock issuable upon exercise of the Warrant (collectively, the
"Securities") have not been registered under the Securities Act of 1933, as
amended (the "Securities Act"), or the securities laws of any state in the
United States, by reason of their contemplated issuance in transactions exempt
from the requirements of the Securities Act, and that the reliance on such
exemption from registration is predicated in part on these representations and
warranties of Purchaser. Purchaser acknowledges that a restrictive legend
consistent with the foregoing has been or will be placed on the certificates
evidencing the Securities. Purchaser understands that neither the Securities and
Exchange Commission ("SEC") nor any state securities commission has approved the
Securities or passed upon or endorsed the merits of the investment or reviewed
or confirmed the accuracy or determined the adequacy of any information
furnished to Purchaser in connection with this Offering;

5.2 Purchaser is acquiring the Securities solely for the account of Purchaser,
for investment purposes only, and not with a view towards the resale or
distribution thereof. Purchaser further agrees not to transfer the Securities in
violation of the Securities Act, or any applicable state securities law, and
that no one other than Purchaser has any beneficial interest in the Securities;

                                        2
<PAGE>

5.3 Purchaser understands that trading of the Common Stock on the OTC Bulletin
Board is limited and sporadic. Purchaser understands that the Securities are
"restricted securities", as said term is defined in Rule 144 promulgated under
the Securities Act ("Rule 144"). Purchaser understands that Rule 144 requires,
among other conditions, a one-year holding period prior to the resale (in
limited amounts) of securities acquired in a non-public offering without having
to satisfy the registration requirements under the Securities Act. Purchaser
understands that the Company makes no representation or warranty regarding its
fulfillment in the future of any reporting requirements under the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), or its dissemination to
the public of any current financial or other information concerning the Company,
as is required by the Rule as one of the conditions of its availability.
Purchaser understands and hereby acknowledges that the Company is under no
obligation to register the Securities acquired hereunder under the Securities
Act;

5.4 Purchaser agrees that it will not sell or otherwise dispose of any of the
Securities unless such sale or other disposition (i) has been registered under
the Securities Act or, in the opinion of counsel, is exempt from registration
under the Securities Act and (ii) has been registered or qualified or, in the
opinion of such counsel, is exempt from registration or qualification under the
applicable state securities laws. Purchaser may not sell, transfer, or otherwise
dispose of the Securities, except in compliance with the applicable rules of the
SEC and applicable state securities authorities;

5.5 Purchaser is an executive officer and/or director of the Company or is
otherwise an "accredited investor", as such term is defined in Rule 501(a) of
Regulation D promulgated under the Securities Act, as indicated by its responses
to the Investor Questionnaire attached hereto as Annex I (the "Investor
Questionnaire") and is sufficiently knowledgeable to understand the risks
involved in purchasing the Securities, and Purchaser, or Purchaser through its
representative, or if Purchaser is a corporation, partnership, limited liability
company, trust or other entity, Purchaser, by and through its officers,
directors, members, trustees, employees or other advisors, (I) is experienced in
evaluating an investment in the Company, (II) has determined that an investment
in the Company is a suitable investment for Purchaser and (III) has such
knowledge and experience in financial and business matters as to be capable of
evaluating the merits and risks of Purchaser's investment in the Company.
Purchaser has the financial ability to bear the economic risks of its entire
investment for an indefinite period, would be able to sustain a complete loss of
its investment, and Purchaser has no need for liquidity with respect to its
investment in the Company. If Purchaser is a natural person, Purchaser has
adequate means for providing for current needs and personal contingencies;

                                        3
<PAGE>

5.6 Purchaser, and if applicable, Purchaser's representative, has received and
carefully reviewed the following documents constituting the periodic and current
reports filed by the Company with the SEC in the past twelve months:

A.    ANNUAL REPORT ON FORM 10-KSB FOR THE FISCAL YEAR ENDED DECEMBER 31, 2005;

B.    QUARTERLY REPORTS ON FORM 10-QSB (AND 10-QSB/A) FOR THE FISCAL QUARTERS
      ENDED MARCH 31, JUNE 30 AND SEPTEMBER 30, 2006 (AS AMENDED); AND

C.    CURRENT REPORTS ON FORM 8-K FILED ON MARCH 23, MARCH 31, APRIL 7, MAY 12,
      JUNE 7, JUNE 29, JULY 25, AUGUST 15, AUGUST 24, OCTOBER 31, NOVEMBER 2,
      NOVEMBER 14, DECEMBER 18 AND DECEMBER 27, 2006.

Purchaser acknowledges and agrees that the foregoing shall be supplemented by
subsequent periodic and current reports filed by the Company with the SEC
pursuant to the Exchange Act. The foregoing enumerated periodic and current
reports and the subsequent periodic and current reports filed by the Company are
hereinafter collectively referred to as the "Company Reports";

5.7 Purchaser, and if applicable, Purchaser's representative, has had a
reasonable opportunity to ask questions of and receive answers from the Company
concerning the Company and the Securities being offered hereby and to verify the
accuracy of any representation or information set forth in this Agreement and
the Warrant (together, the "Subscription Documents") and the Company Reports,
and all such questions, if any, have been answered to the full satisfaction of
Purchaser;

5.8 Purchaser, and if applicable, Purchaser's representative, has received from
the Company, and has reviewed, such information which Purchaser considers
necessary or appropriate to evaluate the risks and merits of an investment in
the Securities, including, without limitation, the Subscription Documents and
the Company Reports and, in particular, Purchaser acknowledges that, as shown in
the financial statements included in the Company's quarterly report on Form
10-QSB/A for the nine month period ended September 30, 2006, the Company has
incurred substantial losses in the past nine months. Purchaser further
acknowledges that as described in the Form 10-QSB/A for the nine month period
ended September 30, 2006, there are a number of factors which may adversely
affect earnings in the near future, including the costs of compliance with the
Formal Agreement;

                                        4
<PAGE>

5.9 Except as set forth in the Subscription Documents, no representations or
warranties have been made to Purchaser, and if applicable, Purchaser's
representative, by the Company or any agent, employee or affiliate of the
Company. Purchaser has relied solely on the representations, warranties,
covenants and agreements of the Company in the Subscription Documents and on
Purchaser's examination and independent investigation in making its decision to
acquire the Securities;

5.10 Purchaser understands that the Securities are being offered and sold
expressly conditioned upon the satisfaction of specific exemptions from the
registration requirements of the federal and state securities laws and that the
Company is relying upon the truth and accuracy of the representations,
warranties, agreements, acknowledgments and understandings of Purchaser set
forth herein and in the Investor Questionnaire in order to determine the
applicability of such exemptions and the suitability of Purchaser to acquire
such Securities;

5.11 Purchaser has full power and authority to execute and deliver this
Subscription Agreement and to perform Purchaser's obligations hereunder, and
this Subscription Agreement is a legally binding obligation of Purchaser
enforceable against Purchaser in accordance with its terms; and

5.12 Purchaser has not incurred any obligation for any finder's, or broker's
agent's fees or commission in connection with the transactions contemplated
hereby.

5.13 Purchaser did not learn of the Offering directly or indirectly, through any
general solicitation or advertising, including, but not limited to, learning of
the Offering as a result of viewing any press releases or similar types of
publicly-available information which directly or indirectly resulted in
Purchaser subscribing for the Shares in the Offering.

VI. Information Furnished by the Undersigned. All the information which the
undersigned has furnished to the Company, or which is set forth herein and in
the Investor Questionnaire, is correct and complete as of the date of this
Subscription Agreement, and if there should be any material change in such
information, Purchaser will immediately furnish such revised or corrected
information to the Company.

                                       5
<PAGE>

VII. Restrictive Legend and Stop-Transfer Instructions.

7.1 Purchaser shall comply with all of the following restrictions prior to
reselling any of the Securities: (a) Until the Securities have been registered
with the SEC, Purchaser shall notify the Company about any proposed resale which
notice must be received by the Company at least twenty (20) business days prior
to such resale; (b) All offers or sales of such Securities by Purchaser may only
be made pursuant to an effective registration statement filed under the
Securities Act or pursuant to an exemption from registration under the
Securities Act and in compliance with all applicable state securities laws; and
(c) If requested by the Company, Purchaser shall provide a satisfactory opinion
from legal counsel that Purchaser's resale complies with this Section 7.1.

7.2 Any certificate or certificates representing the Securities shall bear an
appropriate legend evidencing the preceding restrictions in substantially the
following form:

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY APPLICABLE STATE
SECURITIES LAWS AND MAY NOT BE TRANSFERRED UNTIL (i) A REGISTRATION STATEMENT
UNDER THE ACT OR SUCH APPLICABLE STATE SECURITIES LAWS SHALL HAVE BECOME
EFFECTIVE WITH REGARD THERETO, OR (ii) IN THE OPINION OF COUNSEL ACCEPTABLE TO
THE COMPANY, REGISTRATION UNDER THE ACT OR SUCH APPLICABLE STATE SECURITIES LAWS
IS NOT REQUIRED IN CONNECTION WITH SUCH PROPOSED TRANSFER.

VIII. Indemnification. The undersigned Purchaser agrees to indemnify and hold
harmless the Company and its employees, agents, attorneys and affiliates from
and against all damages, losses, costs and expenses (including attorneys' fees)
which they may incur by reason for the failure of the undersigned to fulfill any
of the terms or conditions of this Agreement, or by reason of any breach of any
of the representations and warranties made by the undersigned herein or in any
document provided by the undersigned Purchaser to the Company.

IX. Confidentiality. Purchaser acknowledges and agrees that all information
relating to the Company and this offering shall be kept confidential by
Purchaser, except as otherwise required by law or, in the case of executive
officers of the Company, in fulfillment of their obligations as employees of the
Company, or made public other than by or through the undersigned.

                                       6
<PAGE>

X. Nontransferability. Neither this Subscription Agreement nor any of the rights
of Purchaser hereunder may be transferred or assigned by Purchaser and any
attempted assignment shall be null and void.

XI. Amendment; Entire Agreement; Governing Law. This Subscription Agreement (i)
may only be modified by a written instrument executed by Purchaser and the
Company, (ii) sets forth the entire agreement of Purchaser and the Company with
respect to the subject matter hereof and supersedes all prior agreements and
understandings between or among the parties with respect to the subject matter
hereof, (iii) shall be governed by the internal laws of the Commonwealth of
Massachusetts, without giving effect to the conflicts of law principles thereof,
and (iv) shall inure to the benefit of, and be binding upon, the Company and
Purchaser and their respective successors and permitted assigns.

XII. Notices. Any notice or other communication given hereunder shall be deemed
sufficient if in writing and sent by reputable overnight courier, facsimile
(with receipt of confirmation) or registered or certified mail, return receipt
requested, addressed to the Company, at First Ipswich Bancorp, 31 Market Street,
Ipswich, Massachusetts 01938, Attention: President, facsimile (978) 356-5937 and
to the Purchaser at the address indicated on the signature page hereof. Notices
shall be deemed to have been given on the date of mailing or fax, except notices
of change of address, which shall be deemed to have been given when received.

XIII. Pronouns; Counterparts. Unless the context otherwise requires, all
personal pronouns used in this Subscription Agreement, whether in the masculine,
feminine or neuter gender, shall include all other genders. This Subscription
Agreement may be executed in counterparts and by facsimile and each of such
counterparts shall constitute an original, and all of which together shall
constitute one and the same document.

                                       7
<PAGE>

IN WITNESS WHEREOF, the undersigned has executed this Subscription Agreement
under seal as of December __, 2006.

Number of Shares: __________________________________________

Aggregate Purchase Price of Shares: $__________________________

Please indicate the form of ownership the undersigned desires for the Shares:
[_] Individual
[_] Joint Tenants with Right of Survivorship (1)
[_] Tenants in Common (2)
[_] Retirement Account
[_] Corporation
[_] Trust
[_] Partnership
[_] Limited Liability Company
[_] Custodian for _________________________________________

Purchaser (please print): _________________________________

___________________________________________________________
      Signature

Please print name and title of signatory, if applicable:

___________________________________________________________

Address: __________________________________________________
         __________________________________________________
         __________________________________________________

Facsimile No: _____________________________________________

E-mail: ___________________________________________________

(1) When stock is held as Joint Tenants with Right of Survivorship, upon the
death of one owner, ownership of the stock will pass automatically to the
surviving owner(s).
(2) When stock is held as Tenants in Common, upon the death of one owner,
ownership of the stock will be held by the surviving owner(s) and by the heirs
of the deceased owner.

                                       8
<PAGE>

                                     ANNEX 1

                             INVESTOR QUESTIONNAIRE

Instructions: Check all boxes below which correctly describe you:

|_| You are: (i) a bank, as defined in Section 3(a)(2) of the Securities Act of
1933, as amended (the "Securities Act"); (ii) a savings and loan association or
other institution, as defined in Section 3(a)(5)(A) of the Securities Act,
whether acting in an individual or fiduciary capacity; (iii) a broker or dealer
registered pursuant to Section 15 of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"); (iv) an insurance company as defined in Section
2(a)(13) of the Securities Act; (v) an investment company registered under the
Investment Company Act of 1940, as amended (the "Investment Company Act"); (vi)
a business development company as defined in Section 2(a)(48) of the Investment
Company Act; (vii) a Small Business Investment Company licensed by the U.S.
Small Business Administration under Section 301 (c) or (d) of the Small Business
Investment Act of 1958, as amended; (viii) a plan established and maintained by
a state, its political subdivisions, or an agency or instrumentality of a state
or its political subdivisions, for the benefit of its employees and you have
total assets in excess of $5,000,000; or (ix) an employee benefit plan within
the meaning of the Employee Retirement Income Security Act of 1974, as amended
("ERISA") and: (1) the decision that you shall subscribe for and purchase shares
of common stock, par value $1.00 per share, of First Ipswich Bancorp (the
"Common Stock") is made by a plan fiduciary, as defined in Section 3(21) of
ERISA, which is either a bank, savings and loan association, insurance company,
or registered investment adviser; (2) you have total assets in excess of
$5,000,000 and the decision that you shall subscribe for and purchase Common
Stock is made solely by persons or entities that are accredited investors, as
defined in Rule 501 of Regulation D promulgated under the Securities Act
("Regulation D"); or (3) you are a self-directed plan and the decision that you
shall subscribe for and purchase Common Stock is made solely by persons or
entities that are accredited investors.

|_| You are a private business development company as defined in Section
202(a)(22) of the Investment Advisers Act of 1940, as amended.

|_| You are an organization described in Section 501(c)(3) of the Internal
Revenue Code of 1986, as amended (the "Code"), a corporation, Massachusetts or
similar business trust or a partnership, in each case not formed for the
specific purpose of making an investment in Common Stock and with total assets
in excess of $5,000,000.

                                       9
<PAGE>

|_| You are a director or executive officer of First Ipswich Bancorp

|_| You are a natural person whose individual net worth, or joint net worth with
your spouse, exceeds $1,000,000 at the time of your subscription for and
purchase of Common Stock.

|_| You are a natural person who had an individual income in excess of $200,000
in each of the two most recent years or joint income with your spouse in excess
of $300,000 in each of the two most recent years, and who has a reasonable
expectation of reaching the same income level in the current year.

|_| You are a trust, with total assets in excess of $5,000,000, not formed for
the specific purpose of acquiring Common Stock, whose subscription for and
purchase of Common Stock is directed by a sophisticated person as described in
Rule 506(b)(2)(ii) of Regulation D.

|_| You are an entity in which all of the equity owners are persons or entities
described in one of the preceding paragraphs.

      The undersigned hereby represents and warrants to the Company that all of
its answers to this Investor Questionnaire are true and correct as of the date
of its execution of the Subscription Agreement for shares of common stock, par
value $1.00 per share, of First Ipswich Bancorp

Purchaser (please print): _____________________________________

By: ___________________________________________________________
      Signature

Please print name and title of signatory, if applicable:

_______________________________________________________________

                                       10Exhibit 4.1 - Filed by EDF Electronic Data Filing Inc. (604) 879.9956

Exhibit 4.1

CITOTECH SYSTEMS INC.

2001 SHARE OPTION PLAN

Dated for Reference September 27, 2001

PART 1

DEFINITIONS AND INTERPRETATION

Definitions

1.1

In this Share Option Plan:

(a)

Accelerated Vesting Event means the occurrence of any one of

(i)

a take-over bid as defined in the Securities Act (British Columbia) is made for Common Shares or Convertible Securities which, if successful would result (assuming the conversion, exchange or exercise of the Convertible Securities, if any, that are the subject of the take-over bid) in any person or persons acting jointly or in concert (as such phrase is defined in the Securities Act (British Columbia)) or persons associated or affiliated with such person or persons within the meaning of the Canada Business Corporations Act beneficially, directly or indirectly, owning shares that would, notwithstanding any agreement to the contrary, entitle the holders thereof for the first time to cast at least three-quarters of the votes attaching to all shares in the capital of the Corporation that may be cast to elect Directors,

(ii)

the acquisition or continuing ownership by any person or persons acting jointly or in concert (as such phrase is defined in the Securities Act  (British Columbia)), directly or indirectly, of Common Shares or of Convertible Securities, which, when added to all other securities of the Corporation at the time held by such person or persons, or persons associated or affiliated with such person or persons within the meaning of the Canada Business Corporations Act (collectively, the “Acquirors”), and assuming the conversion, exchange or exercise of Convertible Securities beneficially owned by the Acquirors, results in the Acquirors beneficially owning shares that would, notwithstanding any agreement to the contrary, entitle the holders thereof for the first time to cast at least three-quarters of the votes attaching to all shares in the capital of the Corporation that may be cast to elect Directors,

(iii)

the sale, lease, exchange or other disposition of all or substantially all of the Corporation’s assets, or

(iv)

an amalgamation, merger, arrangement or other business combination (a “Business Combination”) involving the Corporation that results in the securityholders of the parties to the Business Combination other than the Corporation owning, directly or indirectly, shares of the continuing entity that entitle the holders thereof to cast at least three-quarters of the votes attaching to all shares in the capital of the continuing entity that may be cast to elect Directors;

(b) 

Affiliate means an affiliate of the Corporation as determined under the Canada Business Corporations Act;

(c)

Associate has the meaning ascribed thereto in the Securities Act (British Columbia);

(d)

Board means the board of directors of the Corporation;

(e)

Common Shares means Common shares without par value in the capital of the Corporation;

(f)

Convertible Securities means securities convertible into, exchangeable for or representing the right to acquire Common Shares;

(g)

Corporation means Citotech Systems Inc.;

(h)

Director means a director of the Corporation;

(i)

Disinterested Shareholders’ Approval means approval by a majority of the votes cast by all the Corporation’s shareholders at a duly constituted shareholders’ meeting, excluding votes attached to shares beneficially owned by Insiders;

(j)

Effective Date of an Option means the date on which the Option is granted, whether or not the grant is subject to any Regulatory Approval;

(k)

Employee means a bona fide employee of the Corporation or of a Subsidiary, and includes

(i)

a bona fide permanent part-time employee of the Corporation or an Affiliate, and

(ii)

a bona fide consultant of the Corporation or of an Affiliate who is approved for participation in this Share Option Plan by the Board and in respect of whom the Corporation has qualified by way of an exemption, or has obtained an order from any securities commission or other regulatory authority having jurisdiction over the granting of options to consultants, permitting granting of the Option;

(l)

Expiry Date of an Option means the day on which an Option lapses;

(m)

Insider means

(i)

an insider of the Corporation as defined in the Securities Act (British Columbia), other than a person who is an insider solely by virtue of being a director or senior officer of a Subsidiary, and

(ii)

an Associate of a person who is an Insider by virtue of §(i);

(n)

Officer means an individual who is an officer of the Corporation;

(o)

Option means a right to purchase Common Shares granted under this Share Option Plan to a Director, Officer or Employee;

(p)

Outstanding Issue means the number of Common Shares outstanding on a non-diluted basis;

(q)

Option Commitment means the notice of grant of an Option delivered by the Corporation to an Optionee and substantially in the form of Schedule “A” hereto;

(r)

Optioned Shares means Common Shares subject to an Option;

(s)

Optionee means an individual to whom an Option is granted by the Corporation under this Share Option Plan;

(t)

Regulatory Approval means the approval of the Canadian Venture Exchange and every other stock exchange or securities regulatory agency whose approval is required in the circumstances;

(u)

Retired means

(i)

with respect to an Officer or Employee, the retirement of the Officer or Employee within the meaning of the Canada Pension Plan, after attainment of age 65, and

(ii)

with respect to a Director, cessation of office as a Director, other than by reason of death, after attainment of age 70;

(v)

Share Compensation Arrangement means any stock option, stock option plan, employee stock purchase plan, share distribution plan or any other compensation or incentive mechanism involving the issuance or potential issuance of shares to any Director, Officer or Employee, including a share purchase from treasury which is financially assisted by the Corporation by way of a loan, guaranty or otherwise;

(w)

Share Option Plan means this 2001 Share Option Plan;

(x)

Subscription Price means the amount payable on an exercise of an Option;

(y)

Subsidiary means a subsidiary of the Corporation as determined under the Canada Business Corporations Act;

(z)

Totally Disabled, with respect to an Employee or Officer, means that, solely because of disease or injury the Employee or Officer is deemed by a qualified physician selected by the Corporation to be unable to work at any occupation which the Employee or Officer is reasonably qualified to perform and, with respect to a Director, means that, solely because of disease or injury, the Director is deemed by a qualified physician selected by the Corporation to be unable to carry out his or her responsibilities on the Board;

(aa)

a reference to a statute includes all regulations made thereunder, all amendments to the statute or regulations in force from time to time, and any statute or regulation that supplements or supersedes such statute or regulations; and

(bb)

the words “the last day on which the Officer or Employee worked for the Corporation or an Affiliate of the Corporation” means, with respect to an Officer or Employee whose employment has been terminated by the Corporation or an Affiliate of the Corporation

(i)

other than for cause, either

(A)

the day specified by the Corporation or such Affiliate in writing to the Officer or Employee as being the last day on which the Officer or Employee is to work for the Corporation or a Affiliate of the Corporation, or

(B)

if such Officer or Employee is given pay in lieu of advance notice of a pending effective date of termination, the day on which such notice of termination is given in writing by the Corporation or such Affiliate to the Officer or Employee, and

(ii)

for cause, the day on which the notice of termination was given.

PART 1

SHARE OPTION PLAN

Purpose of Share Option Plan

2.1

The purpose of this Share Option Plan is to recognize contributions made by Directors, Officers and Employees and to provide for an incentive for their continuing relationship with the Corporation and its Affiliates.

Eligibility

2.2

Options to purchase unissued Common Shares may be granted from time to time under this Share Option Plan by the Board to Directors, Officers and Employees.

Incorporation of Terms of Share Option Plan

2.3

Subject to specific variations approved by the Board, all terms and conditions set out herein will be deemed to be incorporated into and form part of each Option granted under this Share Option Plan.

Maximum Shares to be Allotted

2.4

The maximum aggregate number of Common Shares that may be allotted for issuance under this Share Option Plan, is 2,200,000, subject to adjustment in accordance with §3.8.  If Options are surrendered, terminated or expire without being exercised, new Options may be granted covering Common Shares not purchased under such lapsed Options.  

PART 2

TERMS AND CONDITIONS OF OPTIONS

Subscription Price

3.1

The Subscription Price per Common Share to be acquired on the exercise of an Option will be the closing price per share for the Common Shares on the Canadian Venture Exchange (the “Exchange”) on the last trading day on such exchange before the Effective Date of the Option or such other price per share determined by the Board in accordance with the policies of the Exchange. 

Term of Options

3.2

The term of an Option will be such period after the Effective Date thereof, not exceeding 5 years, as the Board determines at the time of granting of the Option.

Vesting of Option Rights

3.3

The vesting periods for all Options granted pursuant to this Plan will be determined at the discretion of the Board at the time of the grant.

Variation of Vesting Periods

3.4

If the Board determines with respect to an Optionee that it is desirable to alter the vesting periods of any particular Option, it may fix the vesting of that Option before or after its grant in such manner as it determines in its discretion, provided however that no variation of vesting periods shall permit Common Shares to be issued to an Optionee any earlier than is required by policies of the Exchange.

3.5

If there occurs an Accelerated Vesting Event each Option held by an Optionee may be exercised by the Optionee at any time or from time to time on or before the Expiry Date of the Option provided that with respect to an Option held by an Officer or Employee the Accelerated Vesting Event must have occurred on or before the last day on which the Officer or Employee worked for the Corporation or an Affiliate of the Corporation.

Limitation on Right to Exercise

3.6

No Option may be exercised after 

(a)

the time at which the Optionee ceases to be a Director, or 

(b)

in the case of an Officer or Employee, 5:00 p.m. Vancouver Time on the last day on which the Officer or Employee worked for the Corporation or an Affiliate of the Corporation

(each of §(a) and (b) being the “particular time”), except as follows:

(i)

an Option that would otherwise so cease to be exercisable by reason of the death of the Optionee at the particular time may be exercised by the personal representatives of the Optionee, from time to time no later than the earlier of the Expiry Date of the Option and one year after the particular time, as to a total number of shares not exceeding the number of shares as to which the Optionee did not exercise the Option before the particular time, including shares as to which pursuant to §3.3 or §3.4 the Optionee was at the particular time not yet entitled to exercise the Option;

(ii)

an Option that would otherwise so cease to be exercisable by reason that the particular time is the effective time that the Optionee has Retired or become Totally Disabled may be exercised by the Optionee or, if the Optionee dies after the particular time, the personal representatives of the Optionee, from time to time no later than the earlier of the Expiry Date of the Option and three years after the particular time, as to a total number of shares not exceeding the number of shares as to which the Optionee did not exercise the Option before the particular time, including shares as to which pursuant to §3.3 or §3.4 the Optionee was at the particular time not yet entitled to exercise the Option;

(iii)

an Option that would otherwise so cease to be exercisable by reason that, in circumstances in which neither §(i) nor §(ii) applies,

(A)

the particular time is the effective time that the Optionee ceases to be a Director, or

(B)

the particular time

(I)

is 5:00 p.m. Vancouver Time on the last day on which the Officer or Employee worked for the Corporation or an Affiliate of the Corporation, except where the office or employment was terminated for cause, and

(II)

is not a time immediately before which the office might have been terminated by the Corporation or an Affiliate of the Corporation, or the employment terminated by the Corporation or an Affiliate of the Corporation, for cause,

may be exercised by the Optionee or, if the Optionee dies after the particular time, the personal representatives of the Optionee, from time to time no later than 5:00 p.m. Vancouver Time on the earlier of the Expiry Date of the Option and the day that is 30 days after the particular time, as to a total number of shares not exceeding the number of shares as to which the Optionee was entitled to and did not exercise the Option immediately before the particular time.

Non-Assignability

3.7

Except as provided in §3.6 or as permitted by applicable regulatory authorities in connection with a transfer to a registered retirement savings plan or registered retirement income fund established by or for the Optionee or under which the Optionee is the beneficiary, an Option may be exercised only by the Optionee to whom it is granted and will not be assignable or transferable.

Adjustment

3.8

The number of Common Shares subject to an Option and the price per share payable on exercise of an Option will be subject to adjustment in the events and in the manner following:

(a)

if the Common Shares are subdivided or consolidated after the Effective Date of an Option, or the Corporation pays to holders of Common Shares of record as of a date after the Effective Date of an Option a dividend payable in Common Shares, 

(i)

the number of Common Shares which would be acquired on any exercise of the Option thereafter will be adjusted to the number of such shares that the Optionee would hold through the combined effect of such exercise and such subdivision, consolidation or stock dividend if the time of the subdivision or consolidation or the record date of such stock dividend had been immediately after the exercise,

(ii)

the price per share payable on such an exercise of such an Option will be adjusted in inverse proportion to the adjustment under §(i) in the number of shares that may be acquired or such exercise, 

and the number of such shares referred to in §2.4 and §5.4(c) and considered as previously allotted for the purposes of applying §2.4 and §5.4(c) will be correspondingly adjusted;

(b)

if there is any capital reorganization, reclassification or other change or event affecting the Common Shares to which §(a) does not apply, the Board will determine whether in the circumstances it is just and equitable that there be some alteration in the securities or other consideration to be acquired by Optionees on the exercise of Options then outstanding and will make such amendments to the Share Option Plan as the Board considers appropriate in the circumstances to ensure a just and equitable result;

(c)

the Corporation will not be required to issue any fractional share in satisfaction of its obligations hereunder or make any payment in lieu thereof.

Disputes

3.9

If any question arises at any time with respect to the Subscription Price or number of Optioned Shares deliverable upon exercise of an Option in any of the events set out in §3.8, such question will be conclusively determined by the Corporation’s auditors, or, if the auditors decline to so act, any other firm of chartered accountants in Vancouver, British Columbia that the Corporation may designate, and such auditors or other firm will have access to all appropriate records and its determination will be binding upon the Corporation and each Optionee.

PART 3

PROCEDURE

Option Commitment

4.1

`Upon the granting of an Option hereunder the Board of the Corporation will deliver to the Optionee an Option Commitment detailing the terms of the Option and upon such delivery the Optionee will be a participant in this Share Option Plan and have the right to purchase the Optioned Shares at the Subscription Price set out therein, subject to the terms of this Share Option Plan.

4.2

Upon the occurrence of an event to which §3.8 applies, the Board may deliver to any Optionee with respect to any Option a revised Option Commitment, identified as such, with respect to shares as to which the Option has not been exercised, reflecting the application of §3.8 by reason of that event.

Manner of Exercise

4.3

An Optionee being entitled to and wishing to exercise an Option may do so only by delivering to the Corporation at its head office

(a)

a written notice addressed to the Corporation specifying the number of Optioned Shares being acquired pursuant to the Option, and

(b)

a certified cheque or bank draft payable to the Corporation for the aggregate Subscription Price for the Optioned Shares being acquired.

Share Certificates

4.4

Upon an exercise of an Option the Corporation will direct its transfer agent to issue a share certificate to an Optionee for the appropriate number of Optioned Shares not later than five days thereafter.

PART 4

GENERAL PROVISIONS

Effective Date of Plan

5.1

This Share Option Plan will become effective on the receipt of both Regulatory Approval and shareholder approval.

Administration

5.2

The Board will be responsible for the general administration of this Share Option Plan, the proper execution of its provisions, the interpretation of this Share Option Plan and the determination of all questions arising pursuant to this Share Option Plan, and without limiting the generality of the foregoing, the Board will have the power to:

(a)

allot Common Shares for issuance in connection with Options granted under the Share Option Plan;

(b)

grant Options hereunder;

(c)

subject to Regulatory Approval, amend, suspend, terminate or discontinue the Share Option Plan, or revoke or alter any action taken in connection therewith except that no amendment or suspension of the Share Option Plan will, without the written consent of all Optionees, alter or impair any Option granted under the Share Option Plan; and

(d)

save and except for the provisions in (a), delegate all or such portion of its powers hereunder as it may determine to one or more committees of the Board, either indefinitely or for such period of time as it may specify, and thereafter each such committee may exercise the powers and discharge the duties of the Board in respect of the Share Option Plan so delegated to the same extent as the Board is hereby authorized so to do.

Limitations on Issue

5.3

The number of Common Shares reserved for issue to any person under this Share Option Plan may not exceed 5% of the Outstanding Issue.  

5.4

Under this Share Option Plan and any other Share Compensation Arrangement, the number of Common Shares that may be

(a)

reserved for issuance to Insiders of the Corporation may not exceed 10% of the Outstanding Issue at that time, 

(b)

issued to Insiders, within a one year period may not exceed 10% of the Outstanding Issue at that time, and

(c)

issued to any one Insider and his or her Associates within a one-year period, may not exceed 5% of the Outstanding Issue at that time.

5.5

For the purposes of §5.4, Common Shares issuable to an Insider pursuant to a stock option or other entitlement that was granted before the person became an Insider will be excluded in determining the number of Common Shares issuable to Insiders.

Amendment

5.6

Subject to Regulatory Approval, the Board may amend, suspend, terminate or discontinue this Share Option Plan, or revoke or alter any action taken pursuant to this Share Option Plan, except that no amendment, suspension, termination or discontinuance of this Share Option Plan will alter or impair any Option without the written consent of the Optionee. 

5.7

Notwithstanding §5.6, the Corporation will be required to obtain prior Disinterested Shareholder Approval of the Share Option Plan (including any amendments thereto) before any of the following can become effective:

(a)

any Option that could result in one of the following:

(i)

the aggregate number of Common Shares reserved for issue to Insiders exceeding 10% of the Outstanding Issue;

(ii)

the issuance to Insiders within a one-year period, of a number of Common Shares exceeding 10% of the Outstanding Issue; or

(iii)

the issuance to any one Insider and his or her Associates, within a one-year period, of a number of Common Shares exceeding 5% of the Outstanding Issue;

(b)

any proposed reduction in the Subscription Price of an Option previously granted to an Insider.

Governing Law

5.8

This Share Option Plan will be construed in accordance with and the rights of the Corporation and each Optionee will be governed by the laws of British Columbia and the laws of Canada applicable therein.

Notice

5.9

Each notice, demand or communication required or permitted to be given under this Share Option Plan will be in writing and will be delivered to the person to whom it is addressed, and  the date of delivery of such notice, demand or communication will be the date of receipt by the addressee.

Employment

5.10

Nothing contained in this Share Option Plan will confer upon any Optionee or Employee any right with respect to employment or continuance of employment with the Corporation or an Affiliate, or interfere in any way with the right of the Corporation or an Affiliate to terminate the Optionee’s or Employee’s employment at any time.  Participation in this Share Option Plan by an Optionee or Employee will be voluntary.

No Representation or Warranty

5.11

The Corporation makes no representation or warranty as to the future market value of Common Shares issued in accordance with the provisions of this Share Option Plan.  Notwithstanding any other provision of this Share Option Plan, the Corporation has no obligation to issue or deliver any Common Shares under this Share Option Plan or to make any other distribution of benefits hereunder unless such issuance, delivery or distribution would comply with all applicable laws and the applicable requirements of any securities exchange or similar entity.

SCHEDULE “A”

2001 SHARE OPTION PLAN

OPTION COMMITMENT

Notice is hereby given that, effective ____________________, 20___ (the “Effective Date”) Citotech Systems Inc. (the “Corporation”), pursuant to the Corporation’s 2001 Share Option Plan (the “Plan”), as it may have been amended to the Effective Date, granted to __________________________________________________________  (the “Optionee”), an Option (the “Option”) to acquire up to ______________________ Common Shares in the capital of the Corporation (the “Optioned Shares”) on or before _______________, _______________ at a Subscription Price of Cdn. $_______________ per share.

The Optioned Shares may be acquired as follows:

Pursuant to the policies of the Canadian Venture Exchange, any Optioned Shares acquired within four months of the date of this commitment form may not be traded until such four-month period has expired and a legend to that effect will be placed on any share certificate issued.  The number of Optioned Shares will be adjusted if and to the extent required in accordance with §3.8 of the Plan.

To exercise the Option, the Optionee must deliver to the Corporation at its head office a written notice addressed to the Corporation specifying the number of Optioned Shares that the Optionee wishes to acquire, together with a certified cheque or bank draft payable to the Corporation for the aggregate Subscription Price for such shares.  A share certificate evidencing the Optioned Shares thereby acquired will be issued to the Optionee by the Corporation’s transfer agent in accordance with the Plan.

CITOTECH SYSTEMS INC.

Per:

______________________________

Authorized Signatory

Per:

______________________________

Authorized Signatory

The Corporation hereby represents that, where options hereunder are being granted to employees, the optionee is a bona fide employee of the company, subsidiary or management company providing services to the listed Corporation (other than investor relations).

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