Document:

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EXHIBIT 10.2

                                  CONFIDENTIAL

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                          LICENSE AND SUPPLY AGREEMENT

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                                     between

                            CombiMatrix Corporation.
                            6500 Harbour Heights Pkwy.
                            Mukilteo, WA 98275
                            USA

                            (hereinafter referred to as "CBMX")

                                                 [SUPPLIER/LICENSOR]

                                       and

                            Roche Diagnostics GmbH
                            Sandhofer Stra(beta)e 116
                            68305 Mannheim

                            Germany

                            (hereinafter referred to as "RDG")

                                                 [PURCHASER/LICENSEE]

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                                  CONFIDENTIAL
                                      -2-

This License and Supply Agreement (the "Agreement"), effective as of July 1,
2001 ("Effective Date"), is made and entered into by and between RDG and CBMX.
RDG and CBMX may be referred to herein individually as a "Party" and
collectively as the "Parties."

RECITALS

WHEREAS

(1)      CBMX and RDG are entering into a broad strategic collaboration in micro
         array technology comprising this Agreement and a Research & Development
         Agreement (the "R&D Agreement") all of which are independent and
         legally binding agreements and are signed and entered into effect on
         the Effective Date.

(2)      CBMX is the owner of intellectual property rights including Know-How
         and various patents, patent applications, copyrights and trademarks in
         the field of array technology including its proprietary micro
         array-technology and is willing to supply RDG with certain CBMX
         products and grant to RDG a related license under the terms and
         conditions of this Agreement;

(3)      RDG desires to purchase certain CBMX proprietary products and obtain a
         related license from CBMX in respect of its intellectual property
         rights under the terms and conditions of this Agreement;

(4)      CBMX and RDG have now agreed to enter into this Agreement and to
         regulate their mutual rights and obligations in the manner hereinafter
         appearing.

NOW, THEREFORE the Parties hereto in consideration of the premises and of the
mutual covenants, agreements, representations and warranties hereinafter set
out, the Parties hereto agree to enter into this Agreement according to the
following terms and conditions:

                                   PARAGRAPH 1
                                   DEFINITIONS
                                   -----------

The following terms shall be defined as follows for the purpose of this
Agreement:

         (1) "Affiliate" shall mean any person, company or entity that, directly
or indirectly, through one or more intermediaries, controls, is controlled by,
or is under common control with, RDG or CBMX. For purposes of this definition,
"control" shall mean the direct or indirect ownership of (a) at least fifty per
cent (50%) or the maximum controlling percentage, if less than fifty per cent
(50%), as allowed by applicable law, of the outstanding voting securities or
participating profit interest of such entity, (b) at least fifty per cent (50%)
of the decision making authority of such

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
                                      -3-

entity, or (c) otherwise has the ability to direct the management of such
entity. Notwithstanding the foregoing, the term "Affiliate" shall not include
Genentech, Inc. a company located at 460 Point San Bruno Boulevard, South San
Francisco, California, U.S.A.

         (2) "Agreement" shall mean this License and Supply Agreement and all
Annexes and Exhibits hereto.

         (3) "Agreements" shall mean this Agreement and the R&D Agreement
collectively."

         (4) "Array(s)" shall mean semiconductor-based CBMX supplied biochip(s)
having nucleic acid biological probe arrays synthesized thereon contained in
Cassettes in sets per Cassette of up to ten Arrays ready for introduction of RNA
or DNA samples prepared from biological specimens.

         (5) "Cassette(s)" shall mean CBMX carrier(s) capable of holding
multiple Arrays; when used without qualification, this term shall refer to
Blank, Custom and Catalogue Cassettes without distinction. "CUSTOM CASSETTE(S)"
shall mean Cassettes containing Custom Arrays. "CATALOGUE Cassettes" shall mean
Cassettes containing only Catalogue Arrays. "BLANK CASSETTES" shall mean
Cassettes containing only Blank Chips.

         (6) "Catalogue Array(s)" shall mean Arrays containing Content developed
by RDG or acquired by RDG that is pre defined and the same from Array to Array,
and which will be publicly available to multiple End Users through
catalogue-type sales by RDG or CBMX.

         (7) "Custom Arrays" shall mean Arrays with Content specified on a
case-by-case basis by RDG or RDG End Users either through specifying the genes
of interest or the actual nucleic acid capture probe sequences, and shall not
include Catalogue Arrays.

         (8) "Confidential Information" shall mean information, including,
without limitation, information related to inventions, technology, know-how,
trade secrets, plans, data, research, development, design, processes,
manufacture, marketing, financial matters, and personnel matters that one Party
discloses to the other in any form, written, oral or otherwise, with the
exception of information which

                  (i) at the time of disclosure is in the public domain or which
                  after disclosure becomes part of the public domain through no
                  fault of the recipient; or

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                  (ii) the recipient can show, by its written records, was
                  already in its possession at the time of disclosure hereunder;
                  or

                  (iii) the recipient can prove was rightfully received from a
                  Third Party, which to the recipient's knowledge, the Third
                  Party, without breach of any obligation of secrecy, is free to
                  disclose to others; or

                  (iv) the recipient can prove, by its written records, was
                  independently developed by the recipient without reference to
                  the confidential information disclosed to it pursuant to this
                  Agreement; or

                  (v) is required by law, regulation, rule, act or order of any
                  governmental authority to be disclosed: provided, that the
                  recipient shall give the disclosing party timely, prior
                  notification if it intends to disclose any Confidential
                  Information in order that disclosing party shall have an
                  opportunity to intervene to limit or prevent disclosure of
                  such Confidential Information; and provided further, that the
                  recipient disclose only the minimum Confidential Information
                  required to be disclosed in order to comply with its
                  disclosure obligations.

         (9) "Content" shall be the compilation of nucleic acid capture probes
on an Array, including their pattern of distribution. Content may include
proprietary nucleic acid sequences and/or may be separately protectable by
patent rights. The copyright to all Content that is nucleic acid capture probes,
and not gene selection, initially synthesized by CBMX and designed by or using
CBMX Software shall be owned by CBMX, it being understood that such copyrights
do not encompass patent rights and intellectual property relating to gene
sequences owned by RDG or RDG-Customers.

         (10) "Distributor" shall mean a reseller, which is not an Affiliate of
a Party, of a Licensed Product purchased from such Party or one of its Sales
Representatives for resale, transfer or other disposition to an End User.

         (11) "Effective Date" shall mean the date defined as such above.

         (12) "Field" shall mean assays and uses of Licensed Products relating
to genetic analysis, testing and research of nucleic acid based genetic
materials, and the creation, maintenance and/or commercialization of nucleic
acid sequence based genetic databases for research purposes (including
pharmaceutical research) and all diagnostic purposes and applications. The
"Field" excludes any assays or uses of the Licensed Products not explicitly
permitted by this definition, including but not limited to, assay or use related
to material sciences proteomics, glycomers, glycoproteins or non-nucleic
acid-based

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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capture molecules including non-nucleic acid molecules assembled onto nucleic
acid capture probes.

         (13) "Hybridizer/Reader" shall mean a hardware device and embedded
Software that combines a nucleic acid hybridization function and an Array
reader, and related components, as described in the Specifications.

         (14) "Major Markets" means the United States, the European Union and
Japan.

         (15) "Net Sales" shall mean, with respect to sales, transfers or other
dispositions of a product by a Party or its Affiliates to End Users or Sales
Representatives the amount invoiced to such End Users or Sales Representative as
reported in the Party's internal accounting system, consistent with the
accounting principles consistently applied in such Party's jurisdiction
(hereinafter referred to as "Gross Amount"), less the following items:

                  i)       the Refund Deduction applicable to such sales or
                           other dispositions; and

                  ii)      value added tax, sales tax and similar taxes levied
                           on such sales or other dispositions, PROVIDED THAT
                           such taxes are separately shown on invoices.

In the event one or more royalty bearing products (that is, Licensed Products,
Royalty bearing Reagents and Content in the case of RDG and Custom Cassettes and
Royalty bearing Reagents in the case of CBMX) is sold together with one or more
other non royalty-bearing products at a single price (such combination is
hereinafter referred to as "Combination Product"), such single price shall be
allocated among the royalty bearing and non royalty bearing product(s) in the
Combination Product based on the average selling price for such products when
sold separately, provided that if any of such non royalty bearing products is
not also then being sold alone, CBMX and RDG shall agree upon the market price
that could reasonably be expected for that product or a comparable product. For
purposes of calculating the Gross Amount and Net Sales, any Catalogue Array and
any Content thereon shall be deemed to be one product. The portion of such
single price allocated to such royalty bearing product(s) in the Combination
Product shall be included in the Gross Amount invoiced used to calculate Net
Sales of such Combination Product in accordance with the applicable formula
above. The portion of such single price allocated to such other non royalty
bearing product(s) in the Combination Product shall not be included in the Gross
Amount used to calculate Net Sales of the Combination Product. "Net Sales" shall
exclude sales, transfers or other dispositions among a Party, its sub licensees
and its Affiliates unless it is an End User. Any product sold, transferred or
otherwise disposed of in other than an arms length transaction or for other
property, E.G., barter shall be deemed invoiced at fair market value in the
country of sale, transfer or disposition.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
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         (16) "Know-How" shall mean all technical information, trade secrets,
know-how and knowledge owned or licensed by CBMX, patentable or not, which is
proprietary and confidential. "Know-How" shall exclude rights to Content.
"Know-How" shall include applicable "Results" under the R&D Agreement.

         (17) "Licensed Patents" means any and all patents or patent
applications owned or controlled by CBMX (including without limitation all
"Results" under the R&D Agreement, divisionals, continuations-in-part, reissues,
reexaminations, extensions and corresponding foreign patents and patent
applications) in existence or hereafter filed and as disclosed and amended from
time to time in ANNEX I to this Agreement, at least one claim of which would be
infringed by the making, using or selling of any Licensed Product by an
unauthorized party. "Licensed Patents" shall exclude rights to Content.

         (18) "Licensed Product(s)"shall mean Catalogue Cassettes, Catalogue
Arrays, Custom Cassettes, Custom Arrays, Blank Chips, Blank Cassettes,
Hybridizer/Reader(s) together with Hybridizer Software, Desk Top Synthesizers,
the Phone Booth Synthesizer provided for in Section 3.1(c), Web Services,
consisting of Probe Design Software and Image Capture Software initially, and
related Software, in each case, for applications only in the Field, and in each
case subject to the limitations set forth in Section 2.1 and elsewhere in this
Agreement. When they are developed under the R&D Agreement, the Licensed
Products shall include Miniarrays (as defined in the R&D Agreement) and
Chiplettes (as defined in the R&D Agreement). The Licensed Products shall not
include Reagents.

         (19) "Reagents" shall mean all chemicals, solutions, reagents materials
and buffers used in purification, labeling, testing, processing and analysis of
biological samples. Royalty bearing Reagents (together with catalogue numbers,
if available) for the purposes of this Agreement are identified in ANNEX II
attached hereto, as such may be amended in writing from time to time by mutual
agreement of the Parties.

         (20) "Refund Deduction" shall mean a deduction from the Gross Amount of
Licensed Products equal to [*] percent ([*]%) of the amount determined by
subtracting from such Gross Amount all separately-invoiced value added taxes,
sales taxes and similar taxes reflected in such Gross Amount, intended by the
Parties, in lieu of deductions for actual expenses, as an allowance for all
expenses to be deducted from Gross Amount to calculate Net Sales (other than
value added taxes, sales taxes and similar taxes), including, without limitation
(a) amounts repayable or creditable because of charge backs, refunds, rebates or
retroactive price reductions, (b) tariffs, duties, excises and other taxes
imposed upon the production, sale, delivery or use of

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
                                      -7-

Licensed Products (excluding value added taxes, sales taxes and similar taxes),
and (c) distribution and other customary expenses, such as freight,
transportation and insurance expenses.

         (21) "Party or Parties" shall mean RDG and/or CBMX.

         (22) "Sales Representatives" is defined in Section 2.2.

         (23) "Software" may, depending on the context of use of the term, mean
(i) software in machine-readable form and software embedded in the
Hybridizer/Reader(s) ("HYBRIDIZER SOFTWARE"), (ii) nucleic acid probe array
design software ("PROBE DESIGN SOFTWARE"), image capture software ("IMAGE
CAPTURE SOFTWARE"), provided on CD ROM or included in the Web Services ("SERVICE
SOFTWARE"), and/or (iii) any other computer software and documentation included
in, shipped with or made available for use with or as a part of the Licensed
Products and licensed and/or sold to RDG by CBMX, and includes any software
manufactured or produced by or on behalf of CBMX and embedded in or used in
connection with use of the Licensed Products, including all modifications,
enhancements, updates and upgrades thereto. Subject to future amendment to this
Agreement, CBMX may provide RDG, with a license to access and use a
comprehensive suite of integrated tools, programs, additional Service Software
(e.g., assay analysis and/or customer data storage software), other Software,
databases and other related items to design, analyze and manage assays, via the
World Wide Web, through the http://my.combimatrix.com website and other related
websites (the "Web Services"). Accordingly, when the term "Web Services" is used
herein, until further amendment to this Agreement, such term shall include only
Probe Design and Image Capture Software. Initially, CBMX will, subject to the
terms and conditions of this Agreement, provide RDG and its End Users with a
license to access and use the Hybridizer Software, Probe Design Software, and
Image Capture Software. CBMX may modify, discontinue, temporarily or
permanently, the Web Services, including removal or addition of functionality or
content, and/or change the terms and conditions of this Agreement that CBMX may
be required to 'pass through' to RDG as a result of a separate agreement between
CBMX and a supplier, provided that the terms of this Agreement are not
materially adversely affected by such "pass through" terms and conditions. It is
understood and agreed that initially the only Web Services available shall
include Image Capture Software and Probe Design Software, and that if RDG
Customers desire to use them, the cost for other Web Services, including data
management, image analysis, bioinformatics, etc., would be charged at the then
current CBMX list price available to other CBMX End Users, it being understood
that RDG Customers may use CBMX Web Services but that such use is not mandatory
and use of other Web Services by RDG Customers does not violate any of the terms
of this Agreement. Coordination, if any, between CBMX and RDG Internet portals
will be subject to future discussion between the Parties.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
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         (24) "Specifications" shall mean the functional specifications for the
Licensed Products set forth on ANNEX III attached hereto. CBMX reserves the
right to make changes to the Specifications, which do not adversely affect
physical or functional interchangeability or performance of any Licensed
Product.

         (25) "Blank Chip(s)" would mean semiconductor-based CBMX-supplied
biochip(s) prepared for the introduction of Content through IN SITU synthesis.

         (26) "Desk Top Synthesizer" shall mean a biochip synthesis unit for
synthesizing Content onto Blank Chips that are arranged in a Cassette, as more
fully described in and to be developed under the R&D Agreement. A Desk Top
Synthesizer shall contain [*] Synthesis Modules. A Synthesis Module is a Content
synthesis device able to hold one Cassette at a time for effecting Content IN
SITU synthesis.

         (27) "Technology" shall mean all Licensed Patents, and Know-How.

         (28) "Territory" shall mean the entire world.

         (29) "Third Party" or "Third Parties" shall mean any person or persons
or entity or entities other than RDG or CBMX, or an Affiliate of RDG or CBMX at
the time of the conclusion of this Agreement.

         (30) "RDG Customer" shall mean [*], that purchases Custom Cassettes,
Custom Arrays, Blank Chips, Blank Cassettes, or related Reagents from CBMX and
that before such purchase first purchased [*]. An RDG Customer shall remain and
be treated as an RDG Customer for the purposes of this Agreement throughout the
term of this Agreement. Notwithstanding the foregoing, for the purposes of this
Agreement, an End User that executes and delivers an agreement with CBMX or any
of its Sales Representatives for the purchase of [*] shall not be treated as an
RDG Customer, except for deliveries to [*] by End User Location [*].

         (31) "End User" or "Sub-licensee" means any person, firm, entity or
corporation that purchases or takes possession from RDG, CBMX or any of their
respective Sales Representatives any of the Licensed Products for use within the
Field.

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
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         (32) "Phone Booth Synthesizer" shall have the meaning in Section
3.1(c).

         (33) "Sales Representative" means a Party, its Affiliates and each of
the Party's and its Affiliates' respective agents, Distributors and sales
representatives through whom such Party sells, transfers or otherwise
distributes any Licensed Product to End Users. RDG Sales Representatives shall
exclude CBMX Sales Representatives and visa versa.

                                   PARAGRAPH 2
                                GRANT OF LICENSE
                                ----------------

2.1 LICENSE AND SUBLICENSE. Subject to the terms and conditions of this
Agreement, CBMX hereby grants to RDG a royalty-bearing world-wide and
non-exclusive (subject to Section 2.1.1 regarding Desk Top Synthesizers) license
to use the Technology only within the Field only for the purposes of (i)
developing Content for Catalogue Arrays and Catalogue Cassettes and (ii)
marketing, distributing, selling and having sold Licensed Products, in the
Territory to End Users, together with a non-exclusive right to sublicense RDG
Affiliates (for as long as they remain RDG Affiliates and provided that RDG
remains responsible for all of its obligations and those of its Affiliates under
this Agreement); provided that as a condition to marketing, distributing,
selling, having sold, disposing or otherwise transferring any applicable
Licensed Product to any End User, RDG and its Affiliates shall comply with the
terms and conditions set forth elsewhere in this Agreement. Section 3.2 (c) and
3.3 (f) provide under certain circumstances for an additional limited license
and manufacturing rights to be granted to RDG. RDG will be free to determine its
own resale and licensing prices of the Licensed Products to End Users. RDG and
its Sales Representatives shall not use, market, sell, distribute, transfer or
dispose of the Technology or Licensed Products for any purpose not licensed or
permitted by this Agreement provided however that the use for any purpose of
biochips by other manufacturers than CBMX by RDG Customers on Hybridizer/Readers
and Desk Top Synthesizers - if such use is technically possible - is beyond
RDG's reasonable control and shall not be a violation of this Agreement
unless such use is promoted or assisted by RDG.

2.1.1 CO-EXCLUSIVE LICENSE OF DESK TOP SYNTHESIZERS. Subject to the terms of
this Agreement and completion of development of Desk Top Synthesizers under the
R&D Agreement and notification by RDG that it is ready for commercial launch of
Desk Top Synthesizers, the license granted in Section 2.1 for the marketing,
distribution, sale, disposal or transfer from RDG or its Affiliates of Desk Top
Synthesizers shall be co-exclusive with CBMX, its Affiliates and Sales
Representatives in the Field and for the term of this Agreement. In the event
that RDG fails to order from CBMX a minimum of [*] Desk Top Synthesizers units
within the first [*] years after the delivery of the first unit to RDG, CBMX
reserves the option to revoke this co-exclusivity license and revert to the
non-exclusive license as otherwise set forth in Section 2.1. Both Parties agree
to meet every [*] years after the initial [*]- year

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
                                      -10-

period to re-negotiate in good faith, and consistent with then market
conditions, the minimum order quantity for the following [*] year period.

2.1.2 MANUFACTURING OPTION FOR HYBRIDIZER/READER. AFTER THE [*] ANNIVERSARY OF
THE EFFECTIVE DATE, the parties agree to discuss and, if appropriate, negotiate
in good faith an amendment to this Agreement to provide additional manufacturing
rights related to Hybridizer/Readers to RDG and to address related issues as
mutually agreed if RDG can provide CBMX with convincing competitive reasons for
its needing such rights.

2.1.3 CERTAIN LICENSE LIMITATIONS. This Agreement does not contemplate the
purchase by RDG from CBMX and the sale, disposal, distribution or transfer by
RDG or its Sales Representatives of Blank Chips, Blank Cassettes, Custom Arrays,
Custom Cassettes, related CBMX Reagents or Probe Design Software. Subject to the
terms and conditions of this Agreement, RDG and its Sales Representatives may
otherwise market such products on behalf of CBMX. Except for synthesis of
nucleic acid on Blank Chips or Blank Cassettes for creation of Custom Arrays by
RDG End Users using Desk Top Synthesizers and synthesis of nucleic acid on Blank
Chips or Blank Cassettes by RDG using its Phone Booth Synthesizer, only CBMX may
synthesize nucleic acid on Blank Chips, Blank Cassettes, Custom Arrays or Custom
Cassettes ordered by RDG End Users. Subject to the terms and conditions of this
Agreement, RDG may, upon completion of their development under the R&D
Agreement, purchase from CBMX and RDG and its Sales Representatives may market,
distribute, sell, have sold, dispose or otherwise transfer to End Users Desk Top
Synthesizers exclusively for synthesis by such End Users of nucleic acid
exclusively on Blank Chips in Blank Cassettes for creation of Custom Arrays
exclusively for internal use by End Users provided however that diagnostic End
Users may sell and commercialize information obtained with Licensed Products. In
connection with such transactions, End Users will be required to use Blank Chips
in Blank Cassettes (supplied at Custom Array/Cassette prices provided for in
this Agreement) and nucleic acid capture probe design software (provided by RDG
or CBMX) and Image Capture Software. RDG's use of the Phone Booth Synthesizer
will be exclusively for synthesis by RDG of Content on Blank Chips for
production of Catalogue Arrays for sale to RDG End Users. CBMX will supply RDG
with Blank Chips in Blank Cassettes for use in the Phone Booth Synthesizer as
set forth in this Agreement and RDG shall not require or have access to any of
the Service Software or Web Services in connection with the use of the Phone
Booth Synthesizer, because no such access is needed.

2.2 MANNER OF DISTRIBUTION. RDG may, subject to Section 2.1, sell and distribute
Licensed Products through its Sales Representatives. RDG shall and shall cause
each of its Sales Representatives to comply with the terms and conditions of
this Agreement and all applicable laws, rules, and regulations. Before and as a
precondition to marketing, distributing, selling, having sold, disposing or
otherwise transferring any Licensed Products to any RDG End Users, RDG and its
Sales Representatives shall

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

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                                  CONFIDENTIAL
                                      -11-

require each RDG End User using Licensed Products to agree to be bound by terms
and conditions of sale mutually agreed upon between the Parties to protect both
their interests. If no such agreement can be reached before [*], RDG and its
Sales Representatives shall be allowed to market, distribute, sell, have sold,
dispose or otherwise transfer Licensed Products to RDG End Users and invoice
those RDG End Users directly under its own terms and conditions of sale but only
if those terms and conditions are consistent with the terms and conditions
contained in this Agreement (including, without limitation, Sections 2, 3.2, and
14.17) and provide at least for the following:

o        SOFTWARE. To the extent RDG and its Sales Representatives market,
         distribute, sell, have sold, dispose or otherwise transfer Software or
         Web Services to RDG End Users, CBMX licensing terms and conditions
         concerning use of and access to Software or Web Services shall be used
         and passed through to such End Users.
o        LEGAL COMPLIANCE. End Users shall comply with applicable laws, rules
         and regulations, including, without limitation, those relating to
         export and products not yet FDA or foreign regulatory agency equivalent
         approved as contemplated by Section 3.4. Additionally, End Users shall
         be responsible for properly disposing of wastes, spent materials,
         laboratory equipment and other materials constituting or used in
         connection with the Licensed Products and personal injury or property
         damage resulting from, or alleged to result from, the improper handling
         of the Licensed Products or the use of non-CBMX authorized materials in
         conjunction with the Licensed Products, including without limitation
         biological material introduced into the Licensed Products by the End
         User.
o        CONTENT. Protection of CBMX copyright for Content as described in
         Section 1 (9) of this Agreement. In particular, CBMX shall own the
         copyright to, and shall have the exclusive right to obtain copyright
         protection for, the Content designed using CBMX Software and its
         identity shall not be disclosed, unless specifically requested by the
         End User, in which case Customer shall pay CBMX the then current CBMX
         list price for a copy of such information. In addition, End Users may
         not use Licensed Products or Web Services to design Content used for
         "Tag Arrays," that is, Content whose purpose is for capturing other
         molecules that are not nucleic acids.
o        COMMERCIAL SERVICES. Unless End Users are not for profit institutions,
         they may not provide to or on behalf of any third party services that
         relate to any Licensed Product or Web Service including commercial
         contract research services; or distribute, transfer, license or
         otherwise make available to a third party any commercial data or
         database that is obtained, in whole or in part, from the use of any
         Licensed Product or Web Service. A service or database is "commercial"
         if access to it is controlled and provided for sale or commercial
         license. Reasonable restrictions on use of Licensed Products providing
         that RDG End Users shall not be allowed to resell, transfer, assign,
         lease, rent, sublicense, provide third party access to or otherwise
         distribute Arrays or Blank Chips synthesized by them or other Licensed
         Products, provided however that diagnostic End Users may sell and
         commercialize information obtained with Licensed Products

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -12-

o        MISC. End Users may not copy, alter, adapt, improve, modify, decode,
         decompile, disassemble, reverse engineer, reproduce Licensed Products,
         in whole or in part.

2.3 TRADEMARKS. CBMX grants to RDG and its Affiliates a non-exclusive,
royalty-free right and license in the Territory to use and refer to the CBMX
names, trademarks, logos, symbols, designs, and other designations ("CBMX
Brands") used in connection with the Licensed Products in order to advertise and
market same to End Users. RDG shall apply the CBMX Brands to the Licensed
Products covered by this Agreement in a manner mutually agreed by the parties.
On Licensed Products sold, transferred or distributed by RDG or any of its Sales
Representatives to End Users, the Parties' brands shall be displayed in
approximately equal prominence to one another. This license is limited to the
use of the CBMX Brands directly on the Licensed Products in the manner agreed by
the Parties or in direct advertising of the Licensed Products or on manual and
support documentation specifically designed to be used in connection with the
Licensed Products. RDG may use its own names, trademarks, logos, symbols,
designs and other designations or brands in connection with the Licensed
Products. In the event RDG uses its own brand identification, RDG shall assume
full responsibility for obtaining any authorization, certification or approvals
for the Licensed Products sold or licensed under or in connection with such
brand identification.

2.4 PATENT MARKINGS. CBMX shall mark all Licensed Products sold under the terms
of this Agreement, or their containers or packages, in accordance with the
applicable patent marking laws to the extent such marking is required by
applicable patent law to preserve Licensed Patents. RDG shall not remove or
modify any CBMX trademark or marking of CBMX. In addition, RDG shall also
appropriately mark its sales and promotional literature, brochures, instruction
booklets, Web site pages and the like, with the Licensed Patent numbers and
patents pending.

                                   PARAGRAPH 3
                           SUPPLY OF LICENSED PRODUCTS
                           ---------------------------

3.1 INITIAL PRODUCTS AND MILESTONE PAYMENTS. CBMX shall, as applicable, either
deliver and sell, or provide evidence of operational effectiveness, to RDG and
RDG shall, according to the following schedule, take delivery of and pay CBMX
for the following prototypes (which shall not be required to meet the applicable
Specifications unless otherwise stated below), for evaluation purposes only (and
not for resale or transfer, or production of any products for sale or transfer,
to Third Parties) by RDG or its Affiliates, of Licensed Products, for the
following purchase prices:

         (a) HYBRIDIZER/READER AND CASSETTE DEVELOPMENT. On or before [*], CBMX
shall notify RDG that CBMX has developed an operationally effective RDG (i)
Hybridizer/Reader and (ii) Cassette ready for hybridization and containing two
Arrays synthesized with test capture probes selected by CBMX. Within thirty days
of such notice technical representatives of the Parties shall meet at CBMX
facilities for demonstration by CBMX of such operational effectiveness.

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -13-

Operational effectiveness of the Hybridizer/Reader is demonstrated when a
Cassette containing an Array is inserted into the Hybridizer/Reader and there is
production of a spatial map of fluorescent density/intensity over a single
Array. Operational effectiveness of the Cassette is demonstrated when an Array
within a Cassette with electric and fluidic connections is synthesized with test
Content and the Array is hybridized with test sample within the Cassette showing
expected positive, negative and null control results. If such operational
effectiveness is demonstrated, or if the thirty day notice period set forth in
this Section passes without any RDG representatives attending the meeting
contemplated by this Section, RDG shall make to CBMX [*].

         (b) DELIVERY OF HYBRIDIZER/READERS Upon delivery of [*] prototype
operationally effective (under Section 3.2 (a)) Hybridizer/Readers for internal
use by RDG and not for resale, which delivery shall not occur later than [*],
RDG shall pay to CBMX [*].

         (c) PHONE BOOTH SYNTHESIZER. Upon delivery, which delivery shall not
occur later than [*], of [*] operationally effective synthesizer modules housed
in one "phone booth" like unit ("Phone Booth Synthesizer") for synthesizing
Content onto Blank Chips arranged in a Cassette, wherein a phone booth-like unit
is a twenty-two inch EIA standard enclosure, without chemical supplies, and
wherein the operational synthesizer modules will be electronically and
fluidically connected and operationally tested at CBMX, each module being able
to hold one Cassette at a time for effecting Content IN SITU synthesis, RDG
shall pay to CBMX [*].

         (d) CUSTOM CASSETTES. CBMX shall no later than [*] make available for
delivery to RDG, Custom Cassettes containing Custom Arrays (for development by
RDG of Content for Catalogue Arrays). RDG shall pay to CBMX [*] per Custom
Array. CBMX shall sell and deliver to RDG Custom Cassettes containing up to a
total of [*] Custom Arrays over 12 months from such date; RDG will pay for such
Cassettes in full over and within such 12 month period but may, at its
discretion, take actual delivery of such Custom Cassettes on a longer schedule
if it desires.

         (e) DELAYED DELIVERIES. In the event CBMX fails to meet any of the
deadlines set forth in this Section 3.1 and RDG does not exercise [*] under this
Agreement, [*] that any such deadline is missed, the applicable payment
otherwise due and payable from RDG shall be reduced by [*].

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -14-

3.2 SUPPLY OF LICENSED PRODUCTS.

         (a) PRICES. Prices for Licensed Products to be purchased from CBMX by
RDG under this Section 3.2 are provided in Section 5.1.4 and ANNEX IV. As a
clarification point, Arrays and Blank Chips are priced by the Array or Blank
Chip, not by the Cassette, although it is intended that Arrays and Blank Chips
will be supplied within Cassettes.

         (b) FORECASTS. Within thirty (30) days of completion of the obligations
of CBMX under Section 3.1 (a)-(d), and on a continuous basis thereafter, RDG and
CBMX will agree to a twelve (12) month rolling forecast for orders of Licensed
Products identified in Section 3.2(a), to be updated quarterly by the first day
of each calendar quarter. The first quarter of each updated forecast shall be
firm, and [*] of the second and [*] of the remaining quarters of each updated
forecast shall be firm. After the first twelve months from the point specified
in the first sentence of this Section, CBMX shall not be obligated to
manufacture and sell to RDG during any calendar month hereunder a number of
Licensed Products greater than [*] of the immediately preceding month's forecast
of Licensed Products.

         (c) ALLOCATION OF LIMITED SUPPLY AND CERTAIN RDG MANUFACTURING RIGHTS.
If for any reason (including but not limited to FORCE MAJEURE) CBMX is unable to
supply the total demand for the products for its customers, it may allocate its
available supply of products among all purchasers on a pro rata basis according
to the proportion of their respective current outstanding orders as determined
in good faith by CBMX. As long as allocation is done in accordance with these
procedures, CBMX shall not incur any liability for any failure of performance
under this Agreement. In the event such allocation lasts more than [*] days and
relates to any Licensed Product, RDG shall be granted certain license and
manufacturing rights as set forth in EXHIBIT A to this Agreement.

         (d) ORDERING PROCEDURE. Letter, telefax or e-mail may issue RDG
Purchase Orders for Licensed Products. The terms and conditions set forth in
this Agreement shall prevail over any terms and conditions included in any
Purchase Order, Acknowledgment or any other forms used by either CBMX or RDG.

         (e) COMPLIANCE WITH LAWS. The Parties shall comply with any and all
applicable laws, regulations, rules and governmental requirements in connection
with their respective obligations under this Agreement.

         (f) WEB SERVICES. For RDG's design of Content for Custom Cassettes and
Arrays under Section 3.1 (c), CBMX will provide RDG with a password, that RDG

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -15-

may change, exclusively for use and access to the Probe Design and Image Capture
Software. That password is exclusively for RDG's, and no other person's use. RDG
is solely responsible for maintaining confidentiality of such password and for
any and all use and access to the Probe Design and Image Capture Software under
RDG's account. RDG agrees to immediately notify CBMX of any unauthorized use of
RDG's password or account or any other breach of security. CBMX or third parties
may provide links from its web site to other World Wide Web sites or resources.
CBMX does not endorse and is not responsible for any data, software or other
content available from such sites or resources. RDG acknowledges and agrees that
CBMX shall not be liable, directly or indirectly, for any damage or loss
relating to RDG's use of or reliance on such data, software or other content.
CBMX takes security issues seriously, and has taken steps to make the Web
Services free from unauthorized access and use. However, security mechanisms
implemented for the Web Services have inherent limitations. Therefore, any loss
or harm caused to RDG's data through use of the Web Services will be borne
exclusively by RDG, and RDG agrees that CBMX shall have no liability for any
such loss or harm.

         (g) RELATED LIMITATIONS. RDG agrees that the Web Services, and related
text, software, sound, photographs, video, graphics, or other material contained
in, or presented to RDG as part of, the Web Services in whatever form
(collectively and individually, the "Web Content") and Software constitutes
valuable proprietary information and trade secrets of CBMX, its licensors and/or
its suppliers, and understands and agrees that it may not copy, alter, adapt,
improve, modify, decode, decompile, disassemble, reverse engineer, reproduce,
disclose, publish, any of Web Content, Software or Licensed Products in whole or
in part. RDG agrees that the obligations in this paragraph shall survive
termination of this Agreement for any reason. Use or access to third party
Software, including Software whose functionality is accessible through the Web
Services or Software may include or make use of certain third party software.
All use of such software shall be governed by such third party license. RDG may
not mount an attack against Web Services, attempt to gain root access, or
conduct any other activity intended to disrupt the Web Services.

         (h) SOFTWARE UPDATES AND UPGRADES. For purposes of this Agreement,
upgrades are defined as providing additional features and functionality, and
updates are defined as performance modifications to correct system operation and
current functions. Software updates shall be provided by CBMX at no cost to RDG.
RDG shall be charged at the then current price for any Software upgrades or
hardware required to support any Software upgrades or updates. CBMX reserves the
right to cease providing upgrades, updates, and services, other than services
required by the terms of this Agreement for any Licensed Products no longer sold
by CBMX.

         (i) RISK OF LOSS AND DELIVERY. In each of RDG's purchase orders, RDG
shall designate a single RDG designated central distribution facility, out of up
to three possible RDG locations, to which CBMX shall be required to deliver all
Licensed

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -16-

Products ordered by RDG for its own use or for resale to RDG Customers or End
Users pursuant to such purchase order. Subject to Section 5.1.8, all prices and
payments to CBMX by RDG for the purchase of Licensed Products are CIP CBMX's
facilities (as such term is defined in the International Chamber of Commerce's
Official Rules for the Interpretation of Trade Terms entitled "Incoterms 2000").
Upon delivery to the carrier at CBMX's facilities, (a) risk of loss to the
Licensed Products shall pass to RDG, and (b) except for title to the Software
which shall remain with CBMX or its licensors at all times, title to the
Licensed Products shall pass to RDG. Unless CBMX receives specific shipping
instructions from RDG, CBMX may, without liability, exercise its discretion in
selecting the method of shipment and the carrier. Time is not of the essence for
CBMX obligations herein. However, CBMX will use its commercially reasonable
efforts to deliver ordered products within thirty (30) days of forecasted
delivery dates under Section 3.2 (b). Subject to Section 3.2(c), as its
exclusive remedy for late deliveries, RDG shall have the right to reject a late
delivery as non-compliant and return it to CBMX at CBMX cost and expense. CBMX
or its representative may make partial deliveries. RDG will be required to
complete any necessary site preparations at its cost.

         (j) INSPECTION AND ACCEPTANCE. RDG shall perform inspection and/or
acceptance testing of the Licensed Products and give detailed written notice to
CBMX of any claim for shortage, damage or that the Licensed Products do not
conform with applicable Specifications. If RDG fails to give such notice within
thirty (30) days of receipt by RDG or its designee, all Licensed Products shall
be deemed to be accepted unconditionally by RDG. If more than [*] of any batch,
that is, a delivery of like kind Licensed Products, of Licensed Products
delivered to RDG or its designee fails to conform with the Specifications under
this Agreement, except for loss or damages during transit or the fault of RDG or
its Sales Representatives, RDG shall have the right to reject the whole batch.
CBMX shall replace non-conforming Licensed Products as soon as reasonably
practicable or, at RDG's choice, refund the purchase price for the
non-conforming Licensed Products. Returns of non-conforming Licensed Products
shall be by shipping means selected by CBMX and shall be at CBMX's cost and
expense and title to all returned Licensed Products shall belong to CBMX. When
contacting CBMX for return instructions (which will include a returned goods
identification number), CBMX must be given the invoice number and date of the
shipment. Except where items were damaged in transit, returns must be in clean
factory packaging. If shipment is delayed at RDG's request, RDG will promptly
reimburse CBMX for all costs of storage.

         (k) LIMITED WARRANTY. Subject to the limitations set forth elsewhere in
this Agreement, CBMX warrants only to RDG that the Licensed Products, other than
Software, under normal use and conditions, will be free from defects in
materials and workmanship and will comply with any then applicable pecifications
for a period of twelve months from the date of shipment to the RDG, provided
that the warranty period for Arrays shall be the longest period provided by CBMX
to any of its End Users. CBMX does not warrant the Software is or will be free
of all defects. CBMX warrants

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -17-

that the Software, other than the Web Services, Probe Design Software or Image
Capture Software, will comply with applicable CBMX published specifications that
are then current for a period of one year from the date of shipment to the RDG.
RDG's exclusive remedy for breach of warranty concerning or other nonconformance
in the Licensed Products will be replacement of the defective portion thereof,
or a refund to RDG, at CBMX sole discretion. CBMX does not warrant that Licensed
Products will work in combination with third-party hardware or software, operate
uninterrupted or error free, or that non-material defects will be corrected.
This warranty does not apply to any defect caused by failure to provide a
suitable storage, use, or operating environment, use of non-recommended reagents
or other materials, or the use of the Licensed Products for a purpose or in a
manner other than that for which they were designed, modifications or repairs
done by RDG, or any other abuse, misuse, or neglect of the Licensed Products.
The warranties and remedies contained herein are exclusive, non-transferable,
and effective only with respect to RDG, and do not apply to any Licensed Product
or any part thereof that (a) has been installed, altered, moved, reinstalled or
repaired by non CBMX authorized personnel or using non CBMX authorized parts,
procedures, or programs, or (b) has not been serviced, and maintained (including
all software and firmware associated with it) pursuant to the manufacturers'
recommendations and/or specifications or as required by CBMX or external codes;
or (c) has been damaged by accident, shipment, handling, abuse, misuse,
modifications, misapplication, or a failure to exercise due caution in cleaning,
maintenance, or operation; or (d) does not comply with the warranty because of
other, non- CBMX products or software. If RDG fails to give notice of a warranty
claim during the applicable warranty period it waives that claim. CBMX and its
suppliers are not obligated to provide service, upgrades, updates, improvements,
or enhancements to Licensed Products beyond those set forth in the Agreement.
CBMX is not responsible for any misuse of or addition to the Licensed Products
by RDG or Third Party vendors. CBMX warranty is only valid provided CBMX
authorized components are used. If RDG expects the Licensed Products or Web
Services to be able to transfer or receive data from non-CBMX products or
systems, RDG shall be responsible for any non- CBMX hardware and software
connections. CBMX will not be responsible for the compatibility of or with non-
CBMX products or systems or the validity of data after transfer or receipt of
data from non CBMX Licensed Products. If RDG modifies any part of the Licensed
Products or Software without CBMX prior written consent, including situations
where such modifications includes the addition of application software to the
Licensed Products, CBMX shall not be responsible for the compatibility of such
modified Licensed Products or Software with other programs, future programs and
releases, or test and verification routines. Additionally, any modifications to
Licensed Products or Software will result in (a) termination of any warranty of
CBMX and/or its licensors with respect thereto; (b) cancellation or increased
fees for service support and (c) termination of the applicable Software License.
To receive the benefits of the limited warranty set forth in this Section RDG
will at all times ensure that all Licensed Products (as appropriate) are
serviced, cleaned, stored and maintained at CBMX recommended specifications and
all operating instructions are followed. The

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -18-

frequency of preventive maintenance and tests performed shall comply with CBMX
recommendations, applicable external codes, laws and regulations. To ensure
proper performance, any and all part repairs and replacements will use CBMX
approved and validated components.

         (l) ONE TIME USE. Cassettes Blank Chips and Arrays supplied hereunder
are licensed for one time use only and may not be reused.

         (m) SERVICE GENERALLY. Any services provided by CBMX under the
Agreement requested or required during non-normal working hours (which are 8:00
a.m. to 5:00p.m, Monday through Friday Pacific Time U.S.A.) are available at
additional cost pursuant to CBMX then current fee schedule. If request service,
other than warranty services, with respect to the Licensed Products, CBMX will
provide such service at the then current time, material and labor rates on then
current standard CBMX terms and conditions for such service.

         (n) TRAINING. If requested by RDG, CBMX shall provide training to RDG
representatives for operation of the Licensed Products at the then current time,
material and labor rates on then current standard CBMX terms and conditions for
such service; provided, however, that the cost for initial training for RDG's or
its Affiliates technical personnel and sales representatives shall be at
mutually agreeable times and at up to three locations (contemplated to be in
Europe, Mukilteo, Washington and Japan) and shall be included in the cost of the
initial products under Section 3.1, with each of the Parties paying their
respective travel and related costs and expenses. RDG shall be responsible for
all expenses and costs associated with attendance by RDG personnel while in
attendance, including all travel and living expenses.

3.3 OTHER CBMX COVENANTS. In addition to CBMX's other obligations and
responsibilities hereunder, CBMX shall perform as follows.

         (a) PATENT MAINTENANCE. CBMX shall prosecute and maintain the Licensed
Patents throughout the term of this Agreement according to commercially
reasonable practices.

         (b) TECHNICAL SUPPORT. RDG will provide the initial contact for support
of End Users to whom it or its Sales Representatives sell Licensed Products and,
within the applicable warranty period, if a problem concerning Software or
instruments cannot be promptly solved to the End User's satisfaction, RDG shall
immediately notify CBMX and the Parties shall then work together to resolve any
End User problem during the applicable warranty period, it being understood that
CBMX will bear the actual cost for any technical support to End Users that is a
result of CBMX Licensed Products delivered not complying with Specifications
under this Agreement as attached under Annex III or Specifications agreed upon
between the Parties in the R&D Agreement.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -19-

         (c) DOCUMENTARY SUPPORT. CBMX shall provide to RDG, at no additional
charge, a complete set of reproducible masters in electronic format of all
applicable end user documentation in English, which RDG may reproduce at RDG's
expense, solely for the purposes of carrying out RDG's obligations and
responsibilities under this Agreement. CBMX will provide modifications to the
documentation, at no additional charge, as they become available in English.

         (d) MODIFICATIONS BY CBMX. After proof of effectiveness under Section
3.3, CBMX shall notify RDG of any changes or modifications to the Licensed
Products as soon as is practical, but in no event will such notice be issued
less than thirty (30) days from introduction of the changes or modifications in
the production version. CBMX reserves the right to substitute changed or
modified Licensed Products for any order made by RDG, but will honor the
purchase price on the order if such order is dated prior to the date of
notification by CBMX to RDG of the changes and modification. CBMX shall inform
RDG of any material changes to the manufacturing process relevant to quality and
Specifications of the Licensed Products. RDG shall have the right to deny its
approval of such changes and CBMX may not implement them, if those changes would
have an adverse impact on quality or performance against Specifications of the
Licensed Products.

         (e) PRICE CHANGES. Prices for License Products sold to RDG may be
subject to adjustment on an annual basis [*]. Any request for changes shall be
notified in the September preceding the calendar year in which the price change
will become effective. The Parties agree to negotiate any such price changes in
good faith. The adjusted price shall become valid for any delivery as of January
1st of the next succeeding calendar year. If an agreement on the price cannot be
reached by the beginning of the succeeding calendar year, the price then
prevailing shall, at least be increased by amount of the increase in raw
materials and labor, provided such price shall in no event be higher than the
lowest contract price CBMX is then charging for similar product sold at the
equivalent volumes to third parties. The price so adjusted shall remain in
force, provided that the Parties shall continue their efforts to agree on a new
price. If the Parties agree on a new price, the revised price shall become
effective as the first day of such fiscal quarter, and RDG shall be debited or
credited accordingly to reflect any adjustment required from the temporary price
that had been in effect. CBMX will honor the immediately previous price on all
orders set for delivery prior to the effective date of any price change and on
all orders dated prior to the date of notice regardless of delivery date.

         (f) DISCONTINUED PRODUCTS. In the event CBMX discontinues manufacturing
or supporting any of the Licensed Products during the term of this Agreement,
CBMX shall give RDG ninety (90) days notice of such discontinuation. Such
notices will include an "End of Product" schedule, which will include dates for

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -20-

end of normal services/support, and the end of spare parts availability. Upon
discontinuation of any Licensed Products where such product is not replaced or
superceded with either a version of the product that has been modified or
improved or a product that performs substantially the same function(s) or
better, RDG shall have the license and manufacturing rights set forth after the
lapse of the Correction Period in Exhibit A to this Agreement for the remainder
of the term of, and subject to the terms of, this Agreement.

3.4 OTHER RDG COVENANTS. (a) CBMX has made RDG aware, and RDG acknowledges, that
the Licensed Products are investigational and have not been reviewed,
registered, authorized, cleared or approved for medical, diagnostic or other
uses regulated by the U.S. Food and Drug Administration ("FDA"), Health Care
Financing Administration ("HCFA") or any foreign equivalents ("Regulatory
Bodies"). Accordingly, RDG shall obtain any and all necessary or required,
reviews, clearances, registrations, authorizations and approvals by Regulatory
Bodies or any other governmental authorities for the manufacturing, marketing
and/or sale of Licensed Products. RDG will be responsible for obtaining and
maintaining at its expense any governmental reviews, clearances, registrations,
authorizations and necessary or required to discharge its obligations within the
Territory. CBMX, however, shall, at RDG's cost and expense, use commercially
reasonable efforts, consistent with its product development and business plans,
to support RDG in its efforts to obtain such approvals, if requested to do so.
RDG shall be entitled to submit such filings in its name; provided, however,
that notwithstanding anything else in this Agreement, CBMX shall have: at all
times full access to and the right to fully use and cross reference all such
submissions, approvals, information and data and, if RDG ceases active marketing
or distribution in a country with respect to a Licensed Product or if a Licensed
Product ceases to be a Licensed Product, to have such submissions, approvals,
information and data transferred to CBMX's name. RDG will assist CBMX in doing
so and will provide CBMX with copies of all the foregoing promptly as they are
created. Notwithstanding the foregoing, CBMX shall be entitled, in its
discretion, to seek any and all necessary or required, reviews, clearances,
registrations, authorizations and approvals by Regulatory Bodies or any other
governmental authorities for the development, manufacturing, use, marketing
and/or sale of Licensed Products as the sponsor of the integrated technology
platform of the Licensed Products for general use, without field of use
limitation, with notice to and coordination with RDG, to the extent necessary,
and as a sponsor, either alone or with other Third Parties, of specific
applications which are not proprietary to RDG, without notice to or coordination
with RDG; provided, however, that notwithstanding anything else in this
Agreement, RDG shall have: at all times full access to and the right to fully
use and cross reference all such submissions, approvals, information and data
for the purpose of fulfilling its obligations under this Agreement.

         (b) INSTALLATION AND TECHNICAL AFTER SALE SUPPORT. Subject to Section
3.3 (b) RDG shall be responsible for all after sale support for the Licensed
Products sold or transferred by RDG or its Sales Representatives to End Users.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -21-

         (c) CONTENT INDEMNITY. Except for infringement actions and validity
challenges of the Licensed Patents as described in Paragraphs 7 and 8 of this
Agreement, RDG agrees to indemnify, defend and hold harmless CBMX, its
Affiliates and their respective inventors, officers, directors, employees and
agents (collectively hereinafter referred to as "the Indemnities") from and
against any and all claims, damages, losses, expenses, fines, penalties, costs,
obligations and other liabilities (including legal cost and fees) asserted by
RDG, its Affiliates, and/or any Third Parties (whether governmental or private)
arising from the, use or sale of any Licensed Product by or for RDG or its Sales
Representatives or arising from the use of any such Licensed Product by any
Third Party including any End User, consumer or any customer of RDG or its Sales
Representatives, including any claims that any of the gene sequences or
fragments thereof provided by RDG, its Sales Representatives, or any of their
respective End Users, consumers or customers in order to construct or design
Content, infringes a patent or copyright. Likewise, CBMX agrees to indemnify,
defend and hold harmless RDG, its Affiliates and their respective inventors,
officers, directors, employees and agents (collectively hereinafter referred to
as "the Indemnities") from and against any and all claims, damages, losses,
expenses, fines, penalties, costs, obligations and other liabilities (including
legal cost and fees) asserted by CBMX, its Affiliates, and/or any Third Parties
(whether governmental or private) arising from the, use or sale of any Custom
Cassettes or Custom Arrays by or for CBMX or its Sales Representatives or
arising from the use of any such products by any Third Party including any End
User, consumer or any customer of CBMX or its Sales Representatives, including
any claims that any of the nucleic acid or gene sequences provided by CBMX, its
Sales Representatives, or any of their respective End Users, consumers or
customers in order for CBMX to construct or design nucleic acid capture probes
on a Custom Array, infringes a patent or copyright.

                                   PARAGRAPH 4
                         REPRESENTATIONS AND WARRANTIES
                         ------------------------------

4.1 CBMX. (a) CBMX represents and warrants that it has the corporate authority
to grant the license to RDG under the Technology, the Agreements create legal,
valid and binding obligations on it and are enforceable against it in accordance
with their respective terms; it is neither aware of the existence of any
lawsuits nor has received notice of any claims, either asserted or implied, of
CBMX Technology's infringement of a patent or other proprietary right anywhere
in the world other than the currently pending litigation between CBMX and its
employee Donald Montgomery on one side and Nanogen, Inc, of San Diego,
California on the other side at the United States District Court, Southern
District of California; Case No.: CV2369 JM RBB ("Nanogen Lawsuit"), and it is
not a party to any agreement, understanding or business relationship that
prevents it from carrying out its obligations under the Agreements.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -22-

         (b) To the best of its knowledge, CBMX is not aware of any rights of
Third Parties that, in the legal opinion of CBMX, are valid and enforceable and
are infringed by the making, using or selling of the Licensed Products. RDG
represents and warrants that it has studied comprehensively the rights of Third
Parties that they may potentially claim relate to the Licensed Products and has
been made aware of these alleged rights by CBMX and concurs in the opinions
expressed by CBMX with respect to such Third Party rights. CBMX represents that
it owns and controls [*] and all divisionals, continuations and corresponding
foreign patents and patent applications [*].

         (c) Except as explicitly set forth in this Agreement CBMX, however,
does not assume any liability of any kind over and above the representations and
warranties related to the infringement or non infringement of any third Party
intellectual property rights or for the efficiency and merchantability of the
Licensed Products and that no comparable competitive products are existing.
Finally, CBMX does not assume any liability that any Licensed Product shall be
registered, authorized or approved by any governmental authorities or any other
institution or supervisory board or similar agencies. CBMX, however, shall use
commercially reasonable efforts to support RDG, at RDG's cost and expense, in
its efforts to obtain such approvals, if RDG is required to do so.

4.2 RDG. RDG represents and warrants that it has the authority to enter into the
Agreements and it is not a party to any agreement, understanding or business
relationship that prevents it from carrying out its obligations under the
Agreements; the Agreements create legal, valid and binding obligations on it and
are enforceable against it in accordance with their respective terms; and RDG
has the full right and corporate power to enter into and perform its obligations
under the Agreements.

4.3 DISCLAIMERS. The Web Services are provided on an 'as is' and 'as available'
basis with all faults and no warranty. CBMX makes no warranty that the Web
Services will meet RDG's requirements or that use of the Web Services will be
error free, uninterrupted, or secure. The representations and warranties set
forth in this Agreement are exclusive and, to the extent permitted by applicable
law, the Parties, their Affiliates, and their respective suppliers, licensors
and representatives specifically disclaim all other representations and
warranties, express or implied, in fact or by law, including, but not limited to
any implied warranty of merchantability, quality or fitness for a particular
purpose, noninfringment, samples previously provided, or course of dealing.

4.4 INDEMNITY. Each Party agrees to indemnify, defend and hold harmless the
other Party, its Affiliates and their respective officers, directors, employees
and agents (collectively hereinafter referred to as the "Indemnities") from and
against any and all claims, damages, losses, expenses, fines, penalties, costs,
obligations and other liabilities (including legal cost and fees) resulting from
Third Party claims actually

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -23-

incurred by any of them arising from, related to or caused by the material
breach of any representation or warranty contained in this Paragraph 4, provided
that any such indemnity shall not exceed individually or collectively an amount
equal to the sum of all payments made by RDG to CBMX under this Agreement and
the R&D Agreement through the date of the event or occurrence giving rise too
the breach. In order to mitigate such liability, CBMX may cease its supply
hereunder of any Licensed Product, if a court of competent jurisdiction issues
an order enjoining CBMX from making, using or selling such Licensed Product.

                                   PARAGRAPH 5
                                    PAYMENTS
                                    --------

5.1.1 INITIAL LICENSE PAYMENT. In consideration of the granting of the rights
hereunder, RDG shall pay to CBMX within fifteen (15) business days from the
Effective Date an up-front payment amounting to [*]).

5.1.2 RUNNING ROYALTIES. In further consideration of the granting of the rights
hereunder, RDG shall on a quarterly basis (as described below) pay to CBMX a
running royalty, at a rate [*] on Net Sales of Licensed Products, and [*] on Net
Sales of Desk Top Synthesizers, purchased from or supplied by CBMX and Net Sales
of Royalty bearing Reagents sold in connection therewith ("Running Royalty"). In
the event any Third Party supplies such Royalty bearing Reagents and RDG or its
Affiliates receive any consideration in connection therewith, the Running
Royalty shall apply to such consideration. In the event that CBMX reverts the
co-exclusive license to a non-exclusive license under Section 2.1.1, the Running
Royalty shall revert also to [*]on Net Sales for Desk Top Synthesizers.

5.1.3 MINIMUM ROYALTIES. Moreover, commencing on [*] RDG shall on a quarterly
basis (as described below) pay to CBMX the greater of the (i) Running Royalty or
(ii) annual minimum royalties regardless of actual sales or revenues calculated
as follows and subject to adjustment only as set forth below: for the first,
second and third calendar year from and after [*] (referred to as "Y1", "Y2" and
"Y3", respectively), the minimum annual royalty shall be [*] (or [*]% of actual
sales per quarter and adjusted upward in the fourth quarter of Y1 if there is a
shortfall in Y1), [*] (or [*] per quarter) and [*] (or [*] per quarter),
respectively ("Minimum Royalties"). With respect to the Minimum Royalties for
Y1, Y2 and Y3, RDG will pay to CBMX, for each of the first three quarters of
each year, a royalty that is equal to the actual calculated Running Royalty on
Licensed Products as described in Section 5.1.2. If the amount of calculated
Running Royalties for either or both of Y1 or Y2 is less than the Minimum
Royalty for that respective year, then in the fourth quarter of each of Y1 and
Y2, the amount of royalties to be paid by RDG to CBMX will be equal to the
Minimum Royalty for that year, less the amount paid for the first three quarters
of that year. During the fourth quarter of Y3,

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -24-

if the Minimum Royalty was paid in Y1 and/or Y2 (rather than the actual Running
Royalty), the amount of paid royalties less the amount of earned royalties for
each year will be treated as a credit offset ("Y3 Adjustment") to the amount
owed by RDG to CBMX when the total royalty for Y3 is calculated. Negative
amounts (earned royalties are greater than paid royalties in any given year)
will not be considered. The following formula shall be used to determine the
amount of any Adjustment:

Y3 TOTAL PAYMENT = [*]
----------------------
Y3 ADJUSTMENT = [*]
-------------------
If Y3 Adjustment = [*], then Y3 Adjustment = [*].
-------------------------------------------------
WHERE:
------
X =[*];
-------
Y = [*]
-------
Z = [*].
--------

After Y1, Y2 and Y3, no minimum royalties shall be due. All royalties on
Licensed Products sold to Third Parties and due to CBMX shall be subject to
deduction of the price RDG paid to CBMX for the Licensed Products or components
of them for the supply of such Licensed Products or components under Section
5.1.4 and Annex IV to this Agreement.

5.1.4 GENERAL PAYMENT TERMS FOR LICENSED PRODUCTS SOLD BY CBMX TO RDG AND CUSTOM
ROYALTIES.
5.1.4.1.1     HYBRIDIZER/READERS. Except for the sale of Hybridizer/Readers from
              CBMX to RDG under Section 3.1, at the time of shipment of
              Hybridizer/Readers from CBMX to RDG, CBMX will invoice RDG the
              price for such Hybridizer/Readers under Annex IV.
5.1.4.1.2     DESK TOP SYNTHESIZERS. At the time of shipment of Desk Top
              Synthesizers from CBMX to RDG, CBMX will invoice RDG the price for
              such Desk Top Synthesizers under Annex IV.
5.1.4.1.3     BLANK CHIPS. At the time of shipment of Blank Chips from CBMX to
              RDG for use by RDG with its Phone Booth Synthesizer, CBMX will
              invoice RDG the price for such Blank Chips under Annex IV. .
5.1.4.1.4     CUSTOM ARRAYS. Except for the sale of Custom Arrays to RDG under
              Section 3.1, before shipment to RDG of additional Custom Arrays
              for development by RDG of Content for Catalogue Arrays CBMX and
              RDG will negotiate a commercially reasonable price in good faith.
5.1.4.1.5     CUSTOM ROYALTIES. On Custom Arrays, Blank Chips (for use with Desk
              Top Synthesizers only) and related Reagents sold by CBMX to RDG
              Customers, CBMX shall pay to RDG on a quarterly basis a royalty of
              [*]

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -25-

              percent of Net Sales ("Custom Royalty"). In the event any Third
              Party supplies such Reagents and CBMX or its Affiliates receive
              any consideration in connection therewith, the Custom Royalty
              shall apply to such consideration.
5.1.4.1.6     CATALOGUE ARRAYS. At the time of shipment of Catalogue Arrays from
              CBMX to RDG for resale to RDG End Users, CBMX will invoice RDG the
              price for such Catalogue Arrays under Annex IV.

5.1.5 STATEMENTS. The amount of the Custom Royalty, Running Royalty and/or
Minimum Royalty payable shall be determined with effect to the end of each
applicable calendar quarter. For that purpose, each Party shall prepare and
deliver to the other an accurate statement. Such statement shall describe the
Net Sales by such Party and its Sales Representatives of the Licensed Products
or Custom Cassettes, as applicable, identify the products, number of product
units sold or disposed of and the countries into which the sales or dispositions
were made and state the amount of the applicable payment amount and shall be
forwarded to the other Party within forty five (45) days from the above
stipulated dates together with the respective payment. The responsible financial
officer of each Party, its independent accounting firm, or the head of its
internal audit committee shall certify in writing that such statement is correct
and complete.

5.1.6 PAYMENT TIMING. The Custom Royalties, Running Royalties and Minimum
Royalties, as applicable, shall be paid in immediately available funds together
with delivery of the statement described in Section 5.1.5 above. RDG will be
invoiced for Licensed Products sold to RDG at the time of shipment as provided
by Section 5.1.4, for services at the time of performance, and for Web Services
beyond those initially provided on a quarterly basis; non disputed payments
shall be due and payable and made in full within thirty (30) days of the date of
the invoice to a location designated by CBMX in the invoice. RDG payments are
not subject to RDG's inspection or acceptance of the Licensed Products or
services CBMX may invoice at any time after shipment of any Equipment or
Software. Payment will not be deemed to have been made until such time as the
funds are available to CBMX at the designated location.

5.1.7 PAYMENT FORM. Unless otherwise stated, all payments between the Parties
are to be made in US dollars in the United States. All conversions from foreign
currency to US dollars will be determined on the last business day of each
calendar quarter in the calendar quarter in which the payment, revenue,
expenditure, or other transaction involving non-US currency occurred, based on
the exchange rate of WALL STREET JOURNAL on the last day of that quarter. RDG
agrees to take all reasonable and necessary steps to register this Agreement in
any country of the Licensed Patents where such is required to permit the
transfer of funds and/or payment of Royalties to CBMX hereunder or is otherwise
required by the government or law of such country to effectuate or carry out
this Agreement. The Parties reserve the right to discuss the possibility of,
subject to mutual agreement between them, payments being made by RDG to CBMX in
currencies other than U.S. Dollars.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -26-

5.1.8 TAXES ON SALES OF LICENSED PRODUCTS TO RDG. Notwithstanding anything to
the contrary in Section 3.2 (i) or the definition of "CIP", (i) all shipping,
freight, insurance, permits, and other handling charges related to
transportation and delivery of Licensed Products ("Shipping Charges") and all
taxes, customs duties, withholdings and the like (except Withholding Taxes and
Import Taxes) (collectively "Taxes"), will be prepaid by CBMX and charged by
CBMX to and paid by RDG; (ii) RDG will pay such Shipping Charges and Taxes
(except Withholding Taxes and Import Taxes) when invoiced by CBMX, or, with
respect to Taxes, will supply appropriate tax exemption certificates in a form
satisfactory to CBMX; (iii) RDG will be responsible for obtaining all necessary
import permits and for the pre-payment of any and all Taxes and duties imposed
on the importation of Licensed Products shipped by CBMX to a destination
designated by RDG ("Import Taxes"); (iv) CBMX will pay all taxes or withholdings
payable on CBMX's income generated from the sale of Licensed Products and
deductible under applicable laws of the United States ("Withholding Taxes"); and
(v) RDG agrees to use its best efforts to do anything necessary to enable CBMX
to claim exemption from the payment of Withholding Taxes under double taxation
or similar agreements in force and shall produce to CBMX proper evidence of
payments of any Withholding Tax.

5.1.9 LATE PAYMENTS. In the event that payments by one Party to the other are
more than 30 (thirty) days late, the Party whose payments are late shall be
obliged to pay to the other an annual interest charge of three months LIBOR plus
3 % (three per cent). Such interest charge shall be payable for each full
calendar month that any payment is late. To secure payments due hereunder for
Licensed Products sold by CBMX to RDG, RDG grants CBMX a continuing general lien
and security interest in and to all of the Licensed Products and proceeds
therefrom, and a limited power of attorney to, on RDG's behalf, execute
appropriate forms, file with appropriate governmental agencies and perfect CBMX
security interest. RDG will execute any necessary documents to perfect CBMX
interest. CBMX shall cancel and release any such recorded lien upon receipt of
full payment for any payments owed by RDG.

                                   PARAGRAPH 6
                                BOOKS AND RECORDS
                                -----------------

Each Party shall keep during the term of this Agreement and for five years
thereafter complete and accurate records reflecting all information necessary or
useful in verifying the accuracy of the reports required by this Agreement
(including Section 5.1.5) and relevant to determination of payments to be made
by the Parties hereunder. Each Party shall have the right to hire an independent
certified public accountant to inspect all such records so required to be kept
by the other (which accountant shall be reasonably acceptable to the other Party
and shall agree in writing to keep all information confidential except as needed
to disclose any discovered discrepancies); provided, such audit: (i) is
conducted during normal business hours, (ii) is conducted no more often

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -27-

then once per year (unless a discrepancy greater than [*]% is discovered in
favor of the auditing Party and provided, however, that either Party shall
always have the right to audit these records based on a specific need, such as
regulatory compliance or in connection with legal or administrative
proceedings), and (iii) is conducted only after the auditing Party has given
reasonable prior written notice. The auditing Party shall bear the full cost and
expense of such audit, unless a discrepancy in excess of [*]% of the amount due
in favor of the auditing Party is discovered, in which event the audited Party
shall bear the full cost and expense of such audit. Regardless of the amount of
discrepancy discovered, all discrepancies (and interest thereon) shall be
immediately due and payable.

                                   PARAGRAPH 7
                       INFRINGEMENT AND VALIDITY CHALLENGE
                       -----------------------------------

The Parties hereto shall inform each other promptly on any infringement of the
Licensed Patents. CBMX shall defend the Licensed Patents against validity
challenges of Third Parties. Upon reasonable request by RDG, CBMX shall take
commercially reasonable actions against any infringer of the Licensed Patents.
Any monetary damage, award or other judgment or recovery that will be
adjudicated in favor of CBMX as a result of such infringement shall belong
exclusively to CBMX. All cost for litigation as a result of a validity challenge
or an infringement shall be borne by CBMX. RDG may join any such action if it is
invited to so join by CBMX. The terms and conditions applicable in such a
scenario, including sharing of any damage, award or other judgment or recovery
that will be adjudicated in favor of CBMX as a result of such infringement would
be reflected in a written amendment to this Agreement signed by both Parties, it
being understood that if RDG joins in such action and bears part of the cost, it
would also obtain an equitable amount of the proceeds depending on its share of
cost participation.

                                   PARAGRAPH 8
                               THIRD PARTY RIGHTS
                               ------------------

8.1 COOPERATION AGAINST INFRINGEMENT CLAIMS. The Parties, after consultation
with their respective legal counsel, in order to reduce expenses and avoid
duplication of defense efforts, have concluded that they will have certain
interests in common in the event either Party is charged, formally or
informally, with or it is alleged by a Third Party that either Party in making,
using or selling the Licensed Products infringes a Third Party right and may be
able to assert certain common defenses. The Parties and counsel for the Parties
emphasize that the purpose of this Section is not to prevent or impede a jury
from fully considering all evidence that should properly come before it at the
trial of such a case, but rather to enable the Parties to minimize the cost and
expense involved in the efforts directed toward their common interests and
defenses and in defending against certain claims made (and expected to be made)
in the lawsuit that are applicable to the Parties. The Parties and their
respective counsel understand that it may become necessary to exchange and
discuss privileged information relating to

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -28-

their common interests and defenses. The Parties and their counsel desire to set
forth the terms under which privileged information will be exchanged and
discussed and wish to memorialize their agreement relating to such charges and
the sharing of privileged information and for the protection of such exchanges
and discussions in reliance upon the joint defense privilege. Accordingly,
because it is in their common interests and to assist the defense of such
claims, the Parties and their counsel may share documents, files, letters, plans
or evidence they have in their possession whether or not same is privileged,
proprietary, or confidential. In order to render legal services to the Parties
and for the purposes of a joint defense, the Parties and their counsel may find
it advisable and necessary to communicate with one another. These communications
may include, without limitation, joint conferences of counsel, joint interviews
of witnesses, deponents, experts, and consultants, and exchanges of documents
and information. The subject matter of these communications and exchanges may
include but may not be limited to (a) strategy and tactics regarding defense of
the litigation; (b) legal memoranda, factual and background memoranda, legal
theories, deposition summaries, notes of witness interviews, and witness
statements and descriptions of produced documents, and (c) other privileged
documents. All such communications and exchanges would be protected from
disclosure to any Third Party by the attorney/client privilege, the attorney
work-product privilege, the trial preparation exclusion, the joint defense
privilege, the party communication privilege, and any other applicable
privileges and protections, and such privileges and protections will not be
waived as a result of such communications and exchanges among the Parties and
their counsel. The documents and information described in this Section and
exchanged and discussed pursuant to this Section would be subject to the
following conditions which the Parties believe and intend will preserve the
confidentiality of such communications and work product pursuant to the joint
defense, common defense and party communication privileges: (a) such documents
would be maintained in confidence by counsel and used by counsel solely for
purposes of rendering legal advice to and defending the Parties in the
applicable proceedings; (b) such documents and information may be disclosed to
outside or in-house counsel (and such counsel's legal assistants, secretaries,
word processing personnel and consultants) representing the Parties in
connection with the defense; (c) such documents and information additionally may
be disclosed to present or former directors, officers or employees of a Party,
for purposes of preparing for deposition or trial, or for purposes of
interviewing potential deponents or witnesses, or for other purposes in
connection with the defense; (d) such documents and information additionally may
be disclosed to expert witnesses and consultants retained by one or more of the
Parties in connection with defense.

8.2 STRATEGY. Except for [*], if either Party is charged with or it is alleged
by a Third Party in a manner that either Party in making, using or selling the
Licensed Products within the Field infringes a Third Party right, then the
Parties shall immediately confer in good faith regarding strategy and a course
of action. In consultation with the other Party, the Party charged with any
infringement shall use best efforts to defend itself against any such
infringement claim while not adversely

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -29-

affecting the other Party's interests by way of settlement, cross claim or third
party claim or otherwise. Each party shall be entitled to engage legal counsel
of its own choosing and [*] the reasonable costs and expenses of such
proceedings (to be calculated, reconciled and paid within 90 days of the end of
a fiscal quarter) insofar as they relate to common issues of law and/or fact;
provided that [*]. Notwithstanding the foregoing, RDG may not settle such
proceedings in a manner that adversely impacts CBMX, unless such settlement is
based on RDG's agreement to pay such Third Party a royalty or other payment.
CBMX shall confer with RDG before CBMX settles any such claims in a manner
adverse to RDG. If RDG settles such proceedings by agreeing to pay a Third Party
a royalty or other payment, then the applicable royalties payable by RDG to CBMX
under this Agreement shall be reduced by [*]; provided, however, that in no case
shall the then applicable royalty rate payable by RDG to CBMX under this
Agreement be reduced by more than [*]. If CBMX settles such proceedings by
agreeing to pay a Third Party a royalty or other payment, then the applicable
royalties payable by RDG to CBMX under this Agreement shall be [*]; provided,
however, that in no case shall the then applicable royalty rate payable by RDG
to CBMX under this Agreement be [*]. Any royalties paid to Third Parties for
Content shall be [*].

8.3 STOP ORDER. If RDG is, as a result of a final, unappealable and conclusive
judgment of a court, ordered to cease making, using or selling the Licensed
Patents in any of the Major Markets, and if CBMX finally fails to secure RDG's
right to further exploit the Licensed Patents in any of the Major Markets, RDG
shall be entitled to immediately stop payment of any Royalties payable hereunder
and terminate this Agreement.

                                   PARAGRAPH 9
                                       [*]
                                       ---

CBMX is under the obligation to [*].

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -30-

                                  PARAGRAPH 10
                              TERM AND TERMINATION
                              --------------------

10.1 TERM. This Agreement shall commence on the Effective Date and shall
continue thereafter in each country in the Territory for as long as the earlier
of fifteen years from the Effective Date or expiration of the Core Patent unless
terminated in accordance with the clauses set forth herein.

10.2 TERMINATION. Either Party shall have the right to terminate this Agreement
with immediate effect by notice in writing to the other Party, upon occurrence
of any of the following events:

         (a)      If the other Party commits a material breach of any of the
                  terms and conditions of this Agreement or the R&D Agreement
                  and does not cure a material breach susceptible of being cured
                  within a period of 60 (sixty) days after having been requested
                  to do so by the non-defaulting Party period (provided,
                  however, that nothing in this subsection shall prevent a Party
                  from seeking immediate, injunctive relief where appropriate to
                  protect proprietary information or such Party's proprietary or
                  intellectual property rights); or

         (b)      if the other Party enters into liquidation whether
                  compulsorily or voluntarily otherwise than for the purpose of
                  amalgamation or reconstruction, or a petition in bankruptcy is
                  filed by or against either Party in any competent court and
                  the same is not dismissed within 120 days; or

         (c)      if the other Party is adjudicated bankrupt or insolvent or if
                  the other ceases to do business, or otherwise terminates its
                  business operations

         (d)      if either Party terminates this Agreement in accordance with
                  the terms of this Agreement.

10.3 EFFECTS OF TERMINATION. Upon any termination or expiration of this
Agreement, the licenses granted under Section 2.1, 2.3 and 3.2(c) shall
terminate and RDG shall no longer be authorized to purchase Licensed Products.
In the event of termination under Section 10.2 or 10.4, all outstanding orders
are subject to cancellation or acceptance by CBMX. Upon any termination or
expiration of this Agreement, CBMX may repurchase and require RDG to sell to
CBMX any unused Licensed Products or other CBMX products in RDG's inventory at
net invoice price. Upon any termination or expiration of this Agreement, the
rights and obligations of the Parties as set forth out in Paragraphs 7, 8, 11,
12, 13 and 14 of this Agreement and any accrued obligations under this Agreement
at the date of such termination shall survive any termination as well as any
other provision intended by their nature to survive

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -31-

termination of this Agreement. With the exception of the foregoing rights and
obligations and, if applicable, those under Section 10.4, all rights and
obligations hereunder shall immediately terminate and cease upon termination or
expiration of this Agreement.

10.4 [*].

                                  PARAGRAPH 11
                                 CONFIDENTIALITY
                                 ---------------

11.1 GENERALLY. CBMX and RDG shall each retain in confidence and not disclose to
Third Parties Confidential Information obtained from the other under this
Agreement. Receiving party will not utilize Confidential Information except for
the express purposes of: performing this Agreement. Both Parties shall be
allowed to disclose Confidential Information if it is disclosed to:

         (i) Consultants and Affiliates of the receiving party who have a
         genuine need to know in connection with the receiving Party's
         performance of this Agreement and are obligated to maintain it in
         confidence pursuant to written agreements.

         (ii) A governmental agency or authority if necessary to obtain
         regulatory approval, reviews clearance, registration, or authorization
         in order to manufacture, develop, market or sell any of the Licensed
         Products, provided that the receiving Party or its may, without
         liability hereunder, disclose only that portion of the which legal
         counsel advises the receiving Party is legally required to be disclosed
         (and only to such persons as such counsel advises the receiving Party
         are legally required) and that the receiving Party exercise its best
         efforts to preserve the confidentiality of the Confidential
         Information, including, without limitation, by cooperating with the
         providing Party to obtain an appropriate protective order or other
         reliable assurance that confidential treatment will be accorded the
         Confidential Information

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -32-

         (iii) To patent authorities as reasonably may be required in a patent
         application filed by CBMX or RDG covering subject matter which is
         encompassed within this Agreement upon consent of the originator of the
         Confidential Information, which consent shall not be unreasonably
         withheld; or

         (iv) To other entities as may be required by law, regulation or
         judicial order, subject to the proviso in clause (ii) above.

Each Party acknowledges that the restrictions contained in this Paragraph 11 are
necessary and reasonable to protect the legitimate interests of the Parties. The
provisions of this Paragraph 11 shall survive the expiration or termination of
this Agreement for a period of five (5) years. Notwithstanding any other
provision of this Agreement, the receiving party or its Affiliates will be
permitted to disclose any Confidential Information if such disclosure:

         (a)      Is in response to a valid order by a court or other
                  governmental body having jurisdiction; or
         (b)      Is otherwise required by law or by the requirements of any
                  competent securities regulatory authority;

PROVIDED, HOWEVER, that the receiving Party will make every effort to inform the
disclosing Party of the order, law or requirement such that the disclosing Party
will have a reasonable opportunity to seek an appropriate protective order.

                                  PARAGRAPH 12
                            DISPUTES AND ARBITRATION
                            ------------------------

12.1 FIRST STAGE CONSULTATION. All disputes, controversies and differences which
may arise between the Parties hereto in respect of this Agreement shall tried to
be settled amicably through mutual consultation within thirty (30) days of a
written settlement request of either Party.

12.2 ICC ARBITRATION. Any disputes arising out of or in connection with this
Agreement, including any question regarding its existence, validity, breach,
violation or termination, shall be exclusively and finally settled under the
Rules of Conciliation and Arbitration of the International Chamber of Commerce
effective January 1st 1998 in the then applicable form ("ICC Rules") by three
arbitrators (the "Arbitral Tribunal") appointed in accordance with the said ICC
Rules. Any award granted by the Arbitral

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -33-

Tribunal shall be final, binding and enforceable against the Parties. The
arbitration shall at all times be held in the English language, provided,
however, that (i) a Party may submit documents in the German language and such
submitted documents will only be translated into the English language if the
Arbitral Tribunal or a Party so requests, and (ii) that the cost of translation
of any such German language documents shall be at the sole expense of the Party
submitting such documents. Any arbitration arising pursuant to f this Agreement
shall be held in New York, N.Y. Discovery shall only be admissible to the extent
permitted and not prohibited under Article 20 of the ICC-Rules and agreed upon
by the Parties who shall cooperate with one another at the outset of the
proceeding to define the extent of discovery reasonably needed to complete the
proceeding. The procedural law of the State of New York shall otherwise be
applied to any proceedings held in connection with said arbitration. Judgment
upon an award rendered by the Arbitrators shall be binding and may be entered in
any court with appropriate jurisdiction, and the Parties consent to jurisdiction
therein for the purpose of such enforcement. Notwithstanding anything to the
contrary contained in this Agreement or elsewhere, each of the parties hereby
acknowledges and expressly agrees that any breach by it of this Agreement, which
does or may result in loss of confidentiality of the Confidential Information,
would cause irreparable harm to the other party for which money damages would
not be an adequate remedy. Therefore, each of the Parties hereby agree, that in
the event of any breach of this Agreement by it, the non-breaching Party will
have the right to seek injunctive relief in a court of competent jurisdiction
against continuing or further breach by the breaching Party, without the
necessity of proof of actual damages, in addition to any other right which
either Party may have under this Agreement, or otherwise in law or in equity.

                                  PARAGRAPH 13
                                 APPLICABLE LAW
                                 --------------

This Agreement shall be governed by and construed under the laws of the State of
New York, and the United States without regard to conflicts of laws provisions
thereof and without regard to the United Nations Convention on Contracts for the
International Sale of Goods. In any action or proceeding to enforce rights under
this Agreement, the prevailing Party shall be entitled to recover costs and
attorneys' fees.

                                  PARAGRAPH 14
                                FINAL PROVISIONS
                                ----------------

14.1. ENTIRE AGREEMENT. This Agreement constitutes the entire understanding
between the Parties hereto concerning the subject matter hereof and supersedes
all other agreements, arrangements and understandings, written or oral,
concerning such subject matter between the Parties, including any existing
confidentiality agreement between them.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -34-

14.2. AMENDMENTS. Any modification of or amendment to this Agreement must be
made in writing. The same applies to any agreement waiving this requirement.

14.3. WAIVERS. A failure or delay on the part of any Party hereto in exercising
any power or right hereunder shall not operate as a waiver by such Party of any
succeeding default by the other, nor shall any single or partial exercise of
such right or power preclude any other or further exercise thereof or the
exercise of any other right or power. A Party's consent to or waiver, express or
implied, of the other Party's breach of its obligations hereunder shall not be
deemed to be construed as a consent to or waiver of any other breach of the same
or any other obligations of the other Party. A Party's failure to complain of
any act, or failure to act, by the other Party, to declare the Party in default,
to insist upon the strict performance of any obligation or condition of this
Agreement or to exercise any right or remedy consequent upon a breach thereof,
no matter how such failure continues, shall not constitute a waiver by such
Party of its rights hereunder, of any such succeeding breach, or of any other
obligation or condition. A Party's consent in any one instance shall not limit
or waive the necessity to obtain such Party's consent in any future instance and
in any event no consent or waiver shall be effective for any purpose hereunder
unless such consent or waiver is in writing and signed by the Party granting
such consent or waiver.

14.4. STATUS OF PARTIES. In its performance under this Agreement, each Party
shall be an independent contractor and neither Party (nor any employee or agent
thereof) shall be an agent or partner of the other Party. Neither party shall
have the right to assume or create obligations on the others behalf, express or
implied.

14.5. HEADINGS. The headings of the various Paragraphs and Sections of this
Agreement are used solely for the convenience of the Parties, do not form part
of this Agreement and are not intended to affect the interpretation or meaning
of this Agreement or to define, limit, extend or describe its scope or intent.

14.6. THIRD PARTIES. None of the provisions of this Agreement shall be for the
benefit of or enforceable by any Third Party except where otherwise expressly
provided in this Agreement.

14.7. DATES. In computing any period of time pursuant to this Agreement, the day
or date of the act, notice, event or default from which the designated period of
time begins to run will not be included. The last day of the period so computed
will be included, unless it is a Saturday or Sunday or other public holiday in
either of the Parties countries of origin in which event the period runs until
the end of the next day which is not a Saturday or Sunday or public holiday.

14.8. CONSTRUCTION. The Parties agree that each Party has reviewed this
Agreement and that any rule of construction to the effect of ambiguities are to
be resolved against the drafting Parties shall not apply to the interpretation
of this Agreement.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -35-

14.9. ASSIGNMENT. This Agreement, and the License, rights and duties contained
in this Agreement shall not be assigned by RDG to any party, except as part of a
sale of RDG's business(es) pertaining to all of the Licensed Products and, in
such event, only collectively and in their entirety. RDG shall give CBMX prior
written notice of such assignment and obtain RDG's assignees' written agreement
to abide by the terms of this Agreement and assume all of RDG's obligations
under this Agreement. Upon such assignment, the term RDG as used in this
Agreement shall thereafter mean the assignee of RDG. This Agreement and rights
and duties contained in this Agreement shall not be assigned by CBMX to any
party, except as part of a sale of CBMX's business(es) pertaining to all of the
Licensed Products and, in such event, only collectively and in their entirety.
CBMX shall give RDG prior written notice of such assignment and obtain CBMX's
assignees' written agreement to abide by the terms of this Agreement and assume
all of CBMX's obligations under this Agreement. Upon such assignment, the term
CBMX as used in this Agreement shall thereafter mean the assignee of CBMX.
Except as otherwise provided in this Agreement, neither Party will have the
right to assign or transfer any of its rights or to delegate any of its duties
under this Agreement without the prior written consent of the other Party. Any
attempted assignment or transfer without such consent will be void and of no
effect, and will automatically terminate all rights of the Party attempting such
assignment or transfer under this Agreement.

14.10. SEVERABILITY. Should any provision of this Agreement be or become invalid
or unenforceable, then the validity and enforceability of the remaining
provisions shall thereby not be affected. The Parties of this Agreement are
under the obligation to use good faith efforts to substitute, if possible, any
invalid or unenforceable provision by a legally effective provision which comes
as close as possible to the economic purpose of the invalid or unenforceable
provision. The same applies to any amendment to this Agreement.

14.11. NOTICES. Notices, requests, reports and other communication in connection
with this Agreement shall be delivered to the addresses of the Parties appearing
in the heading of this Agreement for the attention of

Roche Diagnostics GmbH
Legal Department
         Sandhofer Stra(beta)e 116
         68305 Mannheim DE

         Tel. 0621-759-2971
         Fax. 0621-759-8508

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -36-

         if addressed to CBMX
         6500 Harbour Heights Parkway
         Mukilteo, Washington 98275 US
         Tel +425 493 2000
         Fax +425 493 2010
         for the attention of General Counsel

The address and the person to whom notice should be provided may be altered by
notice so given. Such delivery will be deemed to have occurred upon proof of
delivery by mail, telex, telecopy, or courier.
{NOTE: in final draft fix Section Numbers 14.12-17}

14.12. SURVIVORSHIP. The Agreement will be binding upon and will inure to the
benefit of the Parties hereto and their respective successors and permitted
assigns.

14.13. OFFICIAL LANGUAGE. The official language of this Agreement is English.
Documents or notices not originally written in English will have no effect under
this Agreement until they have been translated into English and the English
translation will then be the controlling form of the document or notice

14.14 INTERPRETATION. When a reference is made in this Agreement to Articles ors
Sections, such reference will be to an Article or Section of this Agreement
unless otherwise indicated. The headings contained in this Agreement are for
reference purposes only and will not affect in any way the meaning or
interpretation of this Agreement. Whenever the words "include", "includes" or
"including" are used in this Agreement they will be deemed to be followed by the
words "without limitation." The phrases "the date of this Agreement," "the date
hereof" and terms of similar import, unless the context otherwise requires, will
be deemed to refer to the date appearing in the introductory paragraph of this
Agreement.

14.15 COUNTERPARTS. This Agreement may be executed in two or more counterparts,
all of which taken together will be considered one and the same agreement and
will become effective when two or more counterparts have been signed by each of
the Parties and delivered to the other Parties, it being understood that all
Parties need not sign the same counterpart.

14.16 FORCE MAJEURE. If the performance of any obligation under this Agreement
(except payment of monies due) by either Party is prevented, restricted or
interfered with by reason of casualty, accident, fire, strikes or labor
disputes, inability to procure materials or components, power or supplies, war
or other violence, any law, order, proclamation, regulation, ordinance, demand
or requirement of any government agency or intergovernmental body, or any other
act, circumstance or condition whatsoever beyond the reasonable control of such
Party, the Party so affected, upon giving notice to the other Party, shall be
excused from such performance to the extent of

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -37-

such prevention, restriction or interference.

14.17 LIMITATION OF LIABILITY. Notwithstanding anything to the contrary in this
Agreement, in no event will either Party be liable for any indirect, punitive,
special, incidental or consequential damage in connection with or related to
this agreement (including loss of profits, use, data, or other economic
advantage), howsoever arising, either out of breach of this agreement, including
breach of warranty, or in tort, even if the other Party has been previously
advised of the possibility of such damage.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -38-

IN WITNESS WHEREOF the Parties hereto have signed this Agreement on this 18thday
of June 2001.

Mannheim, Germany                                       Mukilteo, Washington

ROCHE DIAGNOSTICS GMBH                                  COMBIMATRIX CORPORATION

By: _________________                                   By: ___________________
    Dr. Raehs                                               Gerald D. Knudson

i.V.

By: _________________                                   By: ___________________
    S. Willemsen                                            Edward M. Eadeh

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                                       CONFIDENTIAL
                                                           -39-

<TABLE>
                                                         ANNEX I
                                                     LICENSED PATENTS
<CAPTION>

-------------------------------------------------------------------------------------------------------------------------
                  SERIAL NUMBER
                       OR
DOCKET NUMBER     PATENT NUMBER     COUNTRY      TITLE
-------------------------------------------------------------------------------------------------------------------------
<S>          <C>                    <C>          <C>
0101         [*]                    US           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101WO       PCT/US97/11463         PCT          Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101AU       35884/97               AU           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101BE       0910467                BE           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101CH       0910467                CH           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101DK       0910467                DK           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101EP       97 932 422.5           EP           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101ES       0910467                ES           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101FR       0910467                FR           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101GB       0910467                GB           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101IE       0910467                IE           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101IT       0910467                IT           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101JP       PCT/US97/11463         JP           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101NL       0910467                NL           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0101SE       0910467                SE           Electrochemical Solid Phase Synthesis of Polymers
-------------------------------------------------------------------------------------------------------------------------
0102         6,093,302              US           Electrochemical Solid Phase Synthesis
-------------------------------------------------------------------------------------------------------------------------
0102WO       PCT/US99/00599         PCT          Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0102A        [*]                    USO1         Electrochemical Solid Phase Synthesis
-------------------------------------------------------------------------------------------------------------------------
0102B        [*]                    US02         Electrochemical Solid Phase Synthesis
-------------------------------------------------------------------------------------------------------------------------
0102C        [*]                    US03         Electrochemical Solid Phase Synthesis
-------------------------------------------------------------------------------------------------------------------------
0102AU       22216/99               AU           Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0102CA       2317537                CA           Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0102CN       99803184.4             CN           Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0102EP       99 902 174.4-1270      EP           Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0102JP       2000-527976            JP           Gettering Device for Ion Capture
-------------------------------------------------------------------------------------------------------------------------
0104         [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------
0201         [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------
0202         [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------
0202WO       PCT/US00/02000         PCT          A Method for Selecting Oligonucleotides Having Low Cross Hybridization
-------------------------------------------------------------------------------------------------------------------------
0203B        [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------
0203B-WO                            PCT          Automated System and Process for Custom-Designed Biological Array Design
                                                 and Analysis
-------------------------------------------------------------------------------------------------------------------------
0401         [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------
0401WO       PCT/US00/06676         PCT          Microarrays of Peptide Affinity Probes for Analyzing Gene Products and
                                                 Methods for Analyzing Gene Products
-------------------------------------------------------------------------------------------------------------------------
0402         [*]                    US           [*]
-------------------------------------------------------------------------------------------------------------------------

-------------------------------------------------------------------------------------------------------------------------
??           [*]                                 [*]
-------------------------------------------------------------------------------------------------------------------------

                               Confidential materials omitted and filed separately with the
                             Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                                                               June 18th 2001
between RDG and Combimatrix

</TABLE>
<PAGE>

                                  CONFIDENTIAL
                                      -40-

                                    ANNEX II
                                    REAGENTS

RDG SUPPLIED REAGENTS

PRODUCTS:

A)       EXPRESSION PROFILING (ONLY IF SPECIFIED FOR SPECIFIC ARRAY
         APPLICATIONS)

[*]
[*]
[*]
[*]
[*]
[*]

[*]
[*]
[*]
[*]

[*]

B)       MUTATION ANALYSIS (ONLY IF SPECIFIED FOR SPECIFIC ARRAY APPLICATIONS)

[*]
[*]
[*]
[*]
[*]
[*]
[*]

CBMX SUPPLIED REAGENTS

         [*]
         [*]
         [*]
         [*]

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -41-

                                    ANNEX III
                                 SPECIFICATIONS

                                                            Design Specification

PROJECT NAME:          Prototype Hybridizer/Reader [The Hybridizer/Readers to be
supplied under Section 3.2 shall meet the Specifications in the R&D Agreement.]

RELEASE NO.:           Release 1.0

TARGET RELEASE DATE:   [*]

DATE COMPLETED:
--------------------------------------------------------------------------------

================================================================================
                           PRODUCT CONCEPT/DESCRIPTION
                           ---------------------------
================================================================================

The CBMX Hybridizer/Reader (HR) [*]. The primary benefits to the customer
include [*].

The user supplied System Controller (PC) [*].

The Hybridzer/Reader has the [*] since each Cassette can [*].

The [*] is a specially designed [*] that acts as [*]. The [*] is uniquely
designed to [*]. It consists of [*].

Waste following microarray processing is [*].

--------------------------------------------------------------------------------

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -42-

--------------------------------------------------------------------------------
For customers wishing to [*].

Following [*].

Software for running the Hybridizer/Reader [*].
--------------------------------------------------------------------------------

<TABLE>
<CAPTION>

DESIGN INPUT (RELEASE 1.0)

--------------------------------- ------------------------------------ ---------------------------------------
           PARAMETER                         SPECIFICATION                            COMMENTS
--------------------------------- ------------------------------------ ---------------------------------------
<S>                               <C>                                  <C>

--------------------------------- ------------------------------------ ---------------------------------------

--------------------------------- ------------------------------------ ---------------------------------------
SYSTEM DIMENSIONS                 [*]                                  [*]

                                  [*]
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
OPERATING CONDITIONS              [*]
--------------------------------- ------------------------------------ ---------------------------------------
POWER REQUIREMENTS                [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
GAS REQUIREMENTS                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
SYSTEM WARM-UP TIME               [*]
--------------------------------- ------------------------------------ ---------------------------------------
CASSETTE                          [*]:                                 [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  Dimensions to be provided            [*]
--------------------------------- ------------------------------------ ---------------------------------------

                         Confidential materials omitted and filed separately with the
                        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                                                    June 18th 2001
between RDG and Combimatrix

<PAGE>

                                                 CONFIDENTIAL
                                                     -43-

--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]                                  [*]
CASSETTE INPUT DOOR
--------------------------------- ------------------------------------ ---------------------------------------
REAGENT RESERVOIRS                [*]
--------------------------------- ------------------------------------ ---------------------------------------
TEMPERATURE SENSOR                [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
HEATING/COOLING                   [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
FILTERS                           [*]
--------------------------------- ------------------------------------ ---------------------------------------
LIGHT SOURCE                      [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
CAMERA/OPTICS                     [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
CAMERA/COMPUTER DATA LINK         [*]
--------------------------------- ------------------------------------ ---------------------------------------
ON/OFF LIGHT                                                           [*]
--------------------------------- ------------------------------------ ---------------------------------------
"IN OPERATION LIGHT"                                                   [*]
--------------------------------- ------------------------------------ ---------------------------------------
REAGENT LEVEL MONITOR                                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
CALIBRATION CASSETTE              [*]                                           [*]
--------------------------------- ------------------------------------ ---------------------------------------

                         Confidential materials omitted and filed separately with the
                        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                                                    June 18th 2001
between RDG and Combimatrix

<PAGE>

                                                 CONFIDENTIAL
                                                     -44-

--------------------------------- ------------------------------------ ---------------------------------------
SYSTEM REPRODUCIBILITY            [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
SENSITIVITY                       [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------
PACKAGING                         TBD
--------------------------------- ------------------------------------ ---------------------------------------
LABELS                            TBD
--------------------------------- ------------------------------------ ---------------------------------------
CERTIFICATIONS                    [*]                                  [*]
--------------------------------- ------------------------------------ ---------------------------------------

--------------------------------- ------------------------------------ ---------------------------------------
MANUAL                            [*]                                  To be written and produced by
                                                                       Engineering
--------------------------------- ------------------------------------ ---------------------------------------
</TABLE>

<TABLE>
<CAPTION>
SOFTWARE SPECIFICATIONS

---------------------------------- -------------------------------------------------------------------------
            PARAMETER                                       SPECIFICATION\COMMENTS
---------------------------------- -------------------------------------------------------------------------
<S>                                <C>
LINKS                              [*]
---------------------------------- -------------------------------------------------------------------------
UNIT SERIAL NO. TRACKING           [*]
---------------------------------- -------------------------------------------------------------------------
DATA TRACKING                      [*]
---------------------------------- -------------------------------------------------------------------------
TIME AND TEMPERATURE CONTROL       [*]
---------------------------------- -------------------------------------------------------------------------
SIGNAL NORMALIZATION               [*]
---------------------------------- -------------------------------------------------------------------------
CALIBRATION                        [*]
---------------------------------- -------------------------------------------------------------------------

License and Supply Agreement                                                                  June 18th 2001
between RDG and Combimatrix

<PAGE>

                                                 CONFIDENTIAL
                                                     -45-

---------------------------------- -------------------------------------------------------------------------
CAMERA CONTROL                     [*]
---------------------------------- -------------------------------------------------------------------------
CASSETTE TRAY CONTROL              [*]
---------------------------------- -------------------------------------------------------------------------
LIGHT SOURCE CONTROL               [*]
---------------------------------- -------------------------------------------------------------------------
LAMP USAGE MONITOR                 [*]
---------------------------------- -------------------------------------------------------------------------
IMAGE ACQUISITION                  [*]
---------------------------------- -------------------------------------------------------------------------
IMAGE STORAGE                      [*]
---------------------------------- -------------------------------------------------------------------------
IMAGE/DATA PRINTING                [*]
---------------------------------- -------------------------------------------------------------------------
REAGENT MANAGEMENT                 [*]
---------------------------------- -------------------------------------------------------------------------
LINK TO USER INTERFACE             [*]
---------------------------------- -------------------------------------------------------------------------

License and Supply Agreement                                                                  June 18th 2001
between RDG and Combimatrix
</TABLE>
<PAGE>

                                  CONFIDENTIAL
                                      -46-

                                                            Design Specification

PROJECT NAME:              CBMX 1K Array Cassette
RELEASE NO.:                      Release 1.0 & Release 1.1
TARGET RELEASE DATE:              [*]
DATE COMPLETED:                   [*]
--------------------------------------------------------------------------------

================================================================================
                           PRODUCT CONCEPT/DESCRIPTION
================================================================================

The 1k Array will be [*]. Each 1K Array contains [*].

Release 1.0 [*] will be [*].
Release 1.1 [*] will be [*].

This technology enables [*].

The CBMX Cassette is [*].  The primary benefit to the customer is [*].

The Cassette is [*].

For customers wishing to use alternative hybridization, washing, and imaging
formats, [*].

Along with [*], the cassette label [*].
Cassettes are shipped and stored [*].
Cassettes can be supplied [*].

Each Array chip in each Custom and Catalogue Cassette contains [*].

--------------------------------------------------------------------------------

DESIGN INPUT (RELEASE 1.0 AND RELEASE 1.1)

------------------------------- --------------------------- --------------------
          PARAMETER                   SPECIFICATION               COMMENTS
------------------------------- --------------------------- --------------------
ANODES PER ARRAY                [*]
------------------------------- --------------------------- --------------------
ANODE DIAMETER                  [*]
------------------------------- --------------------------- --------------------
ARRAYS/CASSETTE                 [*]                         [*]
------------------------------- --------------------------- --------------------

------------------------------- --------------------------- --------------------
NO. AVAILABLE ARRAY BAYS PER    [*]
CASSETTE
------------------------------- --------------------------- --------------------
MEMBRANE                        [*]
------------------------------- --------------------------- --------------------
DIMENSIONS                      ARRAYS:
------------------------------- --------------------------- --------------------

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -47-

------------------------------- --------------------------- --------------------
                                CASSETTE:
                                [*]
------------------------------- --------------------------- --------------------
BAR CODE STANDARD               [*]
------------------------------- --------------------------- --------------------
SPOT-TO-SPOT CV                 TBD                         [*]
------------------------------- --------------------------- --------------------
ARRAY-TO-ARRAY CV               TBD                         [*]
------------------------------- --------------------------- --------------------
NULL CONTROL                    [*]                         [*]
------------------------------- --------------------------- --------------------
POSITIVE CONTROL                [*]                         [*]
------------------------------- --------------------------- --------------------
NEGATIVE CONTROL                [*]                         [*]
------------------------------- --------------------------- --------------------

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -48-

------------------------------- --------------------------- --------------------
CASSETTE MATERIAL               TBD
------------------------------- --------------------------- --------------------
CASSETTE COLOR                  TBD
------------------------------- --------------------------- --------------------
LABEL CONTENTS                  TBD
------------------------------- --------------------------- --------------------

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -49-

PROJECT NAME:              COMBIMATRIX SOFTWARE
RELEASE NO.:                       RELEASE 1.0 & RELEASE 1.1
TARGET RELEASE DATE:
DATE COMPLETED:

1. CombiMatrix workspace.

This piece of Software allows a user to [*].

2. Probe Design Software.

[*] proprietary Software has been developed at CombiMatrix to [*].

3. Hybridizer Software.

Once the user gets an Array, he can put it into the Hybridizer/Reader unit to
[*]

4. Data-analysis Software or Image Capture Software.

This Software allows the user on any compatible computer to [*].

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -50-

            COMBIMATRIX 5-MODULE PRODUCTION SYNTHESIZER FOR CASSETTES
                         CONTEMPLATED BY SECTION 3.1 (d)

Consists of:

       ITEM    [*]   [*]

         1        [*]      [*]

         2        [*]      [*]

         3        [*]      [*]

         4        [*]      [*]

         5        [*]      [*]

         6        [*]      [*]

         7        [*]      [*]

         8        [*]      [*]

         9        [*]      [*]

         10       [*]      [*]

[*]:

         1        [*]      [*]

         2        [*]      [*]

         3        [*]      [*]

         4        [*]      [*]

         5        [*]      [*]

          Confidential materials omitted and filed separately with the
        Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -51-

                                    ANNEX IV
                                     PRICES

Price per Array for Catalogue Arrays and Blank Chips (other than those for sale
by CBMX to RDG Customers), will be [*]:

                  [*]                                Price Per Chip
                  ------------------                 --------------
                  [*]                                [*]
                  [*]                                [*]
                  [*]                                [*]
                  [*]                                [*]
                  [*]                                [*]

                  [*]
                  [*]
                  [*]

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -52-

Hybridizer/Readers, other than those under Section 3.1:

                  Number of Units sold per Year                   Price per Unit
                  -----------------------------                   --------------

                  [*]                                             [*]

                  [*]                                             [*]
                  [*]                                             [*]

The price of Desk - Top Synthesizers will be as follows.
                  Number of Units sold per Year                   Price per Unit
                  -----------------------------                   --------------

                  [*]                                             [*]
                  [*]                                             [*]
                  [*]                                             [*]

Future lower pricing for Desk -Top Synthesizers beyond [*] Units sold per year
will be determined at a later date based on further market and competitive
information gathered by either Party and accepted by both Parties.

The price paid by RDG to CBMX for [*] is included in the price paid by RDG to
CBMX for [*].

[*]

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -53-

                                    EXHIBIT A
                        License and Manufacturing Rights

The Parties to this Agreement agree that if (i) [*] and (ii) [*]. Access of RDG
employees and agents to any CBMX facility shall be subject to CBMX's policies
and procedures in effect at such time and shall occur during normal CBMX
business hours. [*].

CBMC shall cooperate with the reasonable requests and instructions of such RDG
employees until [*]; provided, however, that RDG shall indemnify, defend and
hold harmless CBMX, its Affiliates and their respective inventors, officers,
directors, employees and agents (collectively " Indemnities") from and against
any and all claims, damages, losses, expenses, fines, penalties, costs,
obligations and other liabilities (including, without limitation, legal cost and
fees) CBMX or any of the Indemnities may suffer or incur or which might
otherwise arise or be related to [*]; and, provided further, that RDG shall not
materially disrupt CBMX's operations unrelated to [*].

RDG's access to CBMX facilities under this Exhibit shall continue until [*]. If
it appears reasonably probable that [*], then the parties shall cooperate and
perform transition planning necessary to implement the Manufacturing License
described below.

If [*], then RDG shall have a license to [*] in accordance with the following
terms:

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -54-

GRANT OF LICENSE. Effective on a date mutually agreed between the Parties or
[*], CBMX agrees to grant RDG a limited, non-exclusive right and license to
manufacture [*] for use, sale and distribution in accordance with RDG's rights
under this Agreement. Accordingly, CBMX agrees to provide RDG all relevant
information to enable RDG to manufacture [*]. In particular, CBMX shall furnish
RDG with detailed manufacturing instructions and Know-How necessary for
production and shall, subject to any agreements with CBMX's suppliers, supply
RDG with or give RDG access to it's supplies or its suppliers of raw materials
needed for production as well as materials used for controls. As soon as they
are available, CBMX will deposit the detailed manufacturing instructions for
Licensed Products at the office of a public notary or other trustworthy neutral
institution the Parties may mutually agree upon. Such depositary shall disclose
the manufacturing instructions and release them for manufacturing purposes to
RDG upon RDG's written and signed statement ("Statement") that [*]. RDG
shall however inform CBMX before or concurrently with sending the Statement
about its intention to have the manufacturing instructions released from the
depositary. CBMX shall have the right to seek injunctive or other equitable
relief from such release from any court of competent jurisdiction if RDG
delivers the Statement in breach or violation of this Agreement. .

TITLE. Nothing in this Manufacturing License shall be construed to convey or
otherwise grant to RDG any right, title or interest in and to the Technology [*]
other than as required to [*]. CBMX agrees that it take no action to interfere
with RDG's rights granted under this license.

TERMINATION. As soon as [*], CBMX shall notify RDG and the Parties will agree on
an appropriate schedule to phase out manufacturing at RDG's facilities;
provided, however, that, unless terminated earlier, the Manufacturing License,
and the rights granted thereunder, shall automatically terminate on the date
[*]. In addition, this Manufacturing License, and the rights granted hereunder,
shall terminate immediately upon termination of the Agreement.

FEES. In the event RDG exercises its option to [*], the total Running Royalty
for [*] shall be [*].

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and Combimatrix

<PAGE>

                                  CONFIDENTIAL
                                      -55-

NO LIABILITY. CBMX shall not assume any responsibility or liability for [*]
manufactured by RDG under the Manufacturing License. RDG shall indemnify, defend
and hold harmless CBMX and the other Indemnities from and against any and all
claims, damages, losses, expenses, fines, penalties, costs, obligations and
other liabilities (including, without limitation, legal cost and fees) CBMX may
suffer or incur by reason relating to, arising out of or in connection with any
action or claim brought relating to any [*] manufactured under this
Manufacturing License.

NO WARRANTY. RDG agrees that it will only offer the same warranty as the
original CBMX warranty on [*]. CBMX shall not be responsible for any warranty
offered by RDG relating to any Failed Products manufactured by RDG under this
Manufacturing License.

SURVIVAL. The preceding two paragraphs shall survive termination of the
Manufacturing License.

          Confidential materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

License and Supply Agreement                                      June 18th 2001
between RDG and CombimatrixAmendment No. 1 to Credit Agreement and Waiver

EXHIBIT
10.1

AMENDMENT NO. 1

TO

CREDIT AGREEMENT

AND WAIVER

        This AMENDMENT NO. 1 TO CREDIT AGREEMENT AND WAIVER (this "Amendment"), made as of June 30, 2001, among OGLEBAY NORTON COMPANY
("Borrower"), the banking institutions named in Schedule 1 to the Credit Agreement (as hereinafter defined) (collectively, the "Banks" and individually, "Bank"), KEYBANK NATIONAL ASSOCIATION, as administrative agent for
the Banks ("Agent"), BANK ONE, MICHIGAN, as syndication agent ("Syndication Agent") and THE BANK OF NOVA SCOTIA, as documentation agent ("Documentation Agent").

W I T N E S S E T H :

        WHEREAS, Borrower, the Banks, the Agent, the Syndication Agent and the Documentation Agent have entered into that certain Credit Agreement, dated
as of May 15, 1998, as amended and restated as of April 3, 2000 (as amended from time to time, the "Credit Agreement"), pursuant to which the Banks have made certain loans and other financial accommodations available to Borrower;
and

1.1.1.1. WHEREAS, Borrower, the Banks, the Agent, the Syndication Agent and the Documentation Agent desire to amend the Credit Agreement as hereinafter set forth;

        NOW, THEREFORE, in consideration of the mutual promises and agreements contained herein and other good and valuable consideration, the receipt and
adequacy of which are hereby acknowledged, Borrower, the Banks, the Agent, the Syndication Agent and the Documentation Agent do hereby agree as follows:

2.     DEFINED TERMS.

        Each defined term used herein and not otherwise defined herein shall have the meaning ascribed to such term in the Credit Agreement.

3.     AMENDMENT TO THE CREDIT AGREEMENT.

        3.1     Amendment to Article I.    DEFINITIONS.     The definitions of
"Level II Acquisition" and Level II Acquisition Limit" are deleted. The definitions of "Applicable Commitment Fee Rate", "Applicable Margin" and "Level I Acquisition Limit" in Article I are amended to
read as follows:

        "Applicable Commitment Fee Rate" shall mean the number of basis points set forth in the following matrix, based upon the result of the
computation of the Leverage Ratio: 

	
Leverage Ratio

	
Applicable

Commitment Fee Rate

	

  Greater than or equal to 4.50 to 1.00

	
50.00 Basis Points

	

  Greater than or equal to 4.25 to 1.00 but less than 4.50 to 1.00

	
50.00 Basis Points

	

  Greater than or equal to 4.00 to 1.00 but less than 4.25 to 1.00

	
50.00 Basis Points

	

  Greater than or equal to 3.75 to 1.00 but less than 4.00 to 1.00

	
50.00 Basis Points

	

  Greater than or equal to 3.50 to 1.00 but less than 3.75 to 1.00

	
37.50 Basis Points

	

  Less than 3.50 to 1.00

	
37.50 Basis Points

Changes to the Applicable Commitment Fee Rate shall be effective on the first day of the month following the date upon which Agent received, or, if earlier, Agent should have received, pursuant
to Section 5.3 (a) or (b) hereof, the financial statements of the Companies. The above matrix does not modify or waive, in any respect, the requirements of Section 5.7 hereof, the rights of the Banks to charge the Default Rate, or the rights and
remedies of the Banks pursuant to Articles VII and VIII hereof.

        "Applicable Margin" shall mean the number of basis points (depending upon whether the Loans are LIBOR Loans or Prime Rate Loans) set
forth in the following matrix, based upon the result of the computation of the Leverage Ratio:

	
Leverage Ratio

	
Applicable Margin

for LIBOR Loans

	
Applicable Margin

for Prime Rate 

Loans

	

  Greater than or equal to 4.50 to 1.00

	
300 Basis Points

	
50 Basis Points

	

  Greater than or equal to 4.25 to 1.00

  but less than 4.50 to 1.00

	
275 Basis Points

	
25 Basis Points

	

  Greater than or equal to 4.00 to 1.00

  but less than 4.25 to 1.00

	
250 Basis Points

	
0 Basis Points

	

  Greater than or equal to 3.75 to 1.00

  but less than 4.00 to 1.00

	
200 Basis Points

	
0 Basis Points

	

  Greater than or equal to 3.50 to 1.00

  but less than 3.75 to 1.00

	
175 Basis Points

	
0 Basis Points

	

  Less than 3.50 to 1.00

	
150 Basis Points

	
0 Basis Points

Changes to the Applicable Margin shall be effective on the first day of the month following the date upon which Agent received, or, if earlier, Agent should have received, pursuant to Section
5.3 (a) or (b) hereof, the financial statements of the Companies. The above matrix does not modify or waive, in any respect, the requirements of Section 5.7 hereof, the rights of the Banks to charge the Default Rate, or the rights and remedies of
the Banks pursuant to Articles VII and VIII hereof.

        "Level I Acquisition Limit" shall mean Fifteen Million Dollars ($15,000,000).

        3.2     Amendment to Section 5.7     FINANCIAL COVENANTS.  
   Section 5.7 is amended to read as follows:

                 (a)     LEVERAGE RATIO.    The Companies shall not suffer
or permit at any time the Leverage Ratio to exceed: (i) 4.75 to 1.00 on July 1, 2001 through September 30, 2001, (ii) 4.50 to 1.00 on October 1, 2001 through June 30, 2002, (iii) 4.35 to 1.00 on July 1, 2002 through September 30, 2002, and (iv) 4.25
to 1.00 on October 1, 2002 and thereafter.

                 (b)     SENIOR DEBT RATIO.    The Companies shall not
suffer or permit at any time the ratio of Total Senior Funded Indebtedness to Consolidated Pro-Forma EBITDA, based upon the financial statements of the Companies for the most recently completed four (4) fiscal quarters, to be greater than: (i) 3.50
to 1.00 on July 1, 2001 through September 30, 2002 and (ii) 3.25 to 1.00 on October 1, 2002 and thereafter.

                 (c)     INTEREST COVERAGE.     The Companies shall
not suffer or permit at any time the ratio of (x) Consolidated Pro-Forma Pre-Tax Earnings plus Consolidated Pro-Forma Interest Expense to (y) Consolidated Pro-Forma Interest Expense (less non cash amortized financing and FAS 133 costs to the extent
included in Consolidated Pro-Forma Interest Expense in accordance with GAAP), based upon the financial statements of the Companies for the most recently completed four (4) fiscal quarters, to be less than: (i) 1.25 to 1.00 on July 1, 2001 through
December 31, 2001, (ii) 1.30 to 1.00 on January 1, 2002 through June 30, 2002 and (iii) 1.40 to 1.00 on July 1, 2002 and thereafter.

                 (d)     CASH-FLOW COVERAGE.    The Companies shall not
suffer or permit at any time the ratio of (i) Consolidated Pro-Forma Cash flow to (ii) Consolidated Pro-Forma Fixed Charges to be less than 1.10 to 1.00, based upon the financial statements of the Companies for the most recently completed four (4)
fiscal quarters.

                 (e)     NET WORTH.    The Companies shall not suffer or
permit Consolidated Net Worth at any time, based upon the Consolidated financial statements of the Companies for the most recently completed fiscal quarter, to fall below the current minimum amount required, which current minimum amount required
shall be an amount equal to One Hundred Twenty Two Million Three Hundred Five Thousand Dollars ($122,305,000), plus an Increase Amount on the last day of each fiscal quarter ending after April 1, 2001. As used herein, the term "Increase Amount'
shall mean an amount equal to (i) sixty-five percent (65%) of the positive Consolidated Net Earnings of the Companies for the fiscal quarter then ended, plus (ii) one hundred percent (100%) of the proceeds of any equity offering or any debt offering
convertible to equity.

                 (f)     CONSOLIDATED PRO-FORMA EBITDA.   The Companies shall
not suffer or permit at any time Consolidated Pro-Forma EBITDA, based upon the financial statements of the Companies for the most recently completed four (4) fiscal quarters, to be less than (i) Seventy Five Million Dollars ($75,000,000) on July 1,
2001 thorough June 30, 2002, and (ii) Eighty Million Dollars ($80,000,000) on July 1, 2002 and thereafter. 

        3.3 Amendment to Section 5.13     ACQUISITIONS. Section 5.13 is amended to read as follows:

        SECTION 5.13.     ACQUISITIONS.     Without the prior written consent of Agent and the Majority Banks, no
Company shall effect an Acquisition; provided, that, so long as no Unmatured Event of Default or Event of Default shall then exist or immediately thereafter shall begin to exist:

        (a)   Borrower or any Pledgor may effect an Acquisition so long as:

	         	      (i)   Borrower or such Pledgor is the surviving entity of the Acquisition (in the case of a merger, consolidation or other combination)
or the person to be acquired becomes a Pledgor promptly after such Acquisition (in the case of the acquisition of the stock (or other equity interest) of a Person) in accordance with Section 5.22 hereof;
	 	 
	 	      (ii)  the Companies are in full compliance with the Loan Documents both prior to and subsequent to he transaction;
	 	 
	 	      (iii) Borrower provides to Agent and the Banks, at least ten (10) days prior to the consummation of such Acquisition, (A) written notice of
such Acquisition, (B) historical financial statements of such Person, (C) a pro forma financial statement of the companies, and (D) a certificate of a Financial Officer of Borrower showing pro forma compliance with Section 5.7 hereof,
both before and after the proposed Acquisition; and
	 	 
	 	      (iv) the aggregate Consideration paid by the companies with respect to any Level I Acquisition, when added to all other Level I Acquisitions
during any four (4) consecutive fiscal quarters, does not exceed the Level I Acquisition Limit; 

        (b)   Notwithstanding the limitations set forth in subpart (iv) of Section 5.13(a) above, any Company may effect the Permitted
Acquisitions so long as the conditions set forth in subparts (i), (ii) and (iii) of such Section 5.13(a) are satisfied.

        3.4 Amendment to Section 5.18     CAPITAL EXPENDITURES.     Section 5.18 is amended to read
as follows:

        SECTION 5.18    CAPITAL EXPENDITURES    Borrower and its Subsidiaries shall not invest in Consolidated Capital
Expenditures more than an aggregate amount equal to Thirty Five Million Dollars ($35,000,000) during each fiscal year of Borrower.

4.     WAIVER.

        4.1      Waiver.     Subject to and conditioned on the effectiveness of this Amendment, to
the extent that the following actions or circumstances have resulted in Borrower's failure to comply with the Credit Agreement, the Banks, in accordance with Section 10.3 of the Credit Agreement, hereby waive, as of the date of this
Amendment:

	        	        (a)   Borrower's failure to comply with the requirements set forth in Sections 5.7(a), 5.7(b) and 5.7(c) of the Credit
Agreement at June 30, 2001 or for the period ended June 30, 2001; and
	 	 
	 	        (b)   solely with respect to defaults waived pursuant to Section 3.1(a) above, any Event of Default under
Section 7.2 of the Credit Agreement resulting therefrom.

5.     REPRESENTATIONS AND WARRANTIES.

        Borrower hereby represents and warrants as follows:

        5.1     The Amendment.  This Amendment has been duly and validly executed by an authorized executive
officer of Borrower and constitutes the legal, valid and binding obligation of Borrower enforceable against Borrower in accordance with its terms. The execution, delivery, and performance of this Amendment, the Credit Agreement (as amended hereby),
and the other Loan Documents to which Borrower is a party are within Borrower's corporate powers, have been duly authorized, and are not in contravention of Law or the terms of Borrower's Certificate of Incorporation or By-Laws or any indenture
(including the Indenture) or other document or instrument evidencing borrowed money or any other agreement or undertaking to which Borrower is a party or by which it or its property is bound.

        5.2     Claims and Defenses.  As of the date of this Amendment, neither Borrower nor any of the Companies
has any defenses, claims, counterclaims or setoffs with respect to the Credit Agreement, the Loan Documents or any obligations thereunder or with respect to any actions of the Agent, the Syndication Agent, the Documentation Agent, the Banks or any
of their respective officers, directors, shareholders, employees, agents or attorneys, and Borrower irrevocably and absolutely waives any such defenses, claims, counterclaims and setoffs and releases Agent, the Syndication Agent, the Documentation
Agent, the Banks, and each of their respective officers, directors, shareholders, employees, agents and attorneys, from the same.

        5.3     Credit Agreement.  The Credit Agreement, as amended by this Amendment, remains in full force and
effect and remains the valid and binding obligation of Borrower enforceable against Borrower in accordance with its terms.

        5.4     Nonwaiver.  Except as expressly provided in Section 3 hereto, the execution, delivery, performance
and effectiveness of this Amendment shall not operate, be deemed to be, or be construed to be a waiver: (i) of any right, power or remedy of Agent, the Syndication Agent, the Documentation Agent, any Bank under the Credit Agreement or (ii) of any
term, provision, representation, warranty or covenant contained in the Credit Agreement or any other documentation executed in connection therewith. Further, except as set forth in Section 3 of this Agreement, none of the provisions of this
Amendment shall constitute, be deemed to be or
construed to be, a waiver of any Event of Default under the Credit Agreement as previously amended and as further amended by this Amendment. 

        5.5     Reference to and Effect on the Credit Agreement. Upon the effectiveness of this Amendment, each
reference in the Credit Agreement to "this Agreement," "hereunder," "hereof," "herein," or words of like import shall mean and be a reference to the Credit Agreement, as previously amended and as further
amended hereby, and each reference to the Credit Agreement in any other document, instrument or agreement executed and/or delivered in connection with the Credit Agreement shall mean and be a reference to the Credit Agreement, as previously amended
and as further amended hereby.

6.    CONDITIONS PRECEDENT TO EFFECTIVENESS OF THIS AMENDMENT NO. 1 AND WAIVER.

        This Amendment shall become effective as of the date (the "Amendment Effective Date") on which each of the following conditions
precedent shall have been fulfilled:

        6.1     Amendment No. 1 to Credit Agreement and Waiver.    The Agent shall have
received from Borrower and a requisite number of Banks constituting the Majority Banks (as defined in the Credit Agreement) an original counterpart of this Amendment No. 1 to Credit Agreement and Waiver, executed and delivered by a duly
authorized officer of Borrower or each such Bank, as the case may be.

        6.2     Amendment No. 1 to Loan Agreement and Waiver.     The Agent shall have
received from Borrower and a requisite number of Banks constituting the Majority Banks an original counterpart of Amendment No. 1 to Loan Agreement and Waiver, in form and substance acceptable to the Agent, executed and delivered by a duly
authorized officer of Borrower or each such Bank, as the case may be.

        6.3     Acknowledgment of Guarantors.     The Agent shall have received the
Acknowledgment of Guarantors, attached hereto, executed and delivered by a duly authorized officer of each of the Guarantors.

        6.4     Amendment Fee.     The Agent shall have received from Borrower, for
account of each Bank that consents to this Amendment No. 1 to Credit Agreement and Waiver (evidenced by receipt by the Agent of an executed counterpart of this Amendment No. 1 to Credit Agreement and Waiver) by 5:00 p.m., Cleveland, Ohio time, on
August 6, 2001, an amendment fee in an amount equal to 0.15% of the sum of each such approving Bank's Revolving Credit Commitment. 

7.    MISCELLANEOUS.

        7.1     Governing Law.   This Amendment has been delivered and accepted at and shall be deemed to have
been made at Cleveland, Ohio. This Amendment shall be interpreted and the rights and liabilities of the parties hereto determined in accordance with the laws of the State of Ohio, without regard to principles of conflict of law, and all other laws
of mandatory application.

        7.2     Severability.    Each provision of this Amendment shall be interpreted in such manner as
to be valid under applicable law, but if any provision hereof shall be invalid under applicable law, such provision shall be ineffective to the extent of such invalidity, without invalidating the remainder of such provision or the remaining
provisions hereof.

        7.3     Counterparts.    This Amendment may be executed in one or more
counterparts, each of which, when taken together, shall constitute but one and the same agreement.

[Signature Page to Follow]

         IN WITNESS WHEREOF,  Borrower has caused this Amendment No. 1 to Credit Agreement and Waiver to be duly executed and delivered
by its duly authorized officer as of the date first above written.

	Address: 	   	1100 Superior Avenue	   	OGLEBAY NORTON COMPANY
	 	 	Cleveland, Ohio 44114	 	 
	 	 	Attention: Treasurer	 	By:                            
              
	 	 	 	 	Name: Rochelle F. Walk                      
	 	 	 	 	Title: Vice President and Secretary  
	  	 	 	 	 
	Address:	 	Key Center	 	KEYBANK NATIONAL ASSOCIATION,
	 	 	127 Public Square 	 	 
	 	 	Cleveland, Ohio 44114-1306	 	 
	 	 	Attention: Large Corporate	 	By:                            
              
	 	 	Banking Division  	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address:	 	611 Woodward Avenue	 	BANK ONE, MICHIGAN
	 	 	Detroit, Michigan 48226	 	 
	 	 	Attention: Large Corporate 	 	By:                            
              
	 	 	Banking Division 	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address: 	 	600 Peachtree Street	 	THE BANK OF NOVA SCOTIA
	 	 	Suite 2700	 	 
	 	 	Atlanta, Georgia 30308	 	By:                            
              
	 	 	Attention: Large Corporate	 	Name:                           
           
	 	 	Banking Division	 	Title:                           
             

	Address:	 	500 Woodward Avenue, 9th Fl.	 	COMERICA BANK
	 	 	Detroit, Michigan 48226	 	 
	 	 	Attention: Large Corporate	 	By:                            
              
	 	 	Banking Division 	 	Name:                         
             
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address:	 	231 S. LaSalle Street 	 	BANK OF AMERICA, N.A.
	 	 	Chicago, Illinois 60697	 	 
	 	 	Attention: Peter J. Gates	 	By:                            
              
	 	 	Banking Division 	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address:	 	111 West Monroe, 10W	 	HARRIS TRUST AND SAVINGS BANK
	 	 	Chicago, Illinois 60603	 	 
	 	 	Attention: Large Corporate 	 	By:                            
              
	 	 	Banking Division	 	Name:                           
           
	 	 	 	 	Title:                           
             
	   	 	 	 	 
	Address:	 	975 Euclid Avenue 	 	THE HUNTINGTON NATIONAL BANK
	 	 	Cleveland, Ohio 44115	 	 
	 	 	Attention: Large Corporate	 	By:                            
              
	 	 	Banking Division	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address:	 	1111 Superior Avenue 	 	MELLON BANK, N.A.
	 	 	Suite 1600	 	 
	 	 	Cleveland, Ohio 44114	 	By:                            
              
	 	 	Attention: Large Corporate	 	Name:                           
           
	 	 	Banking Division	 	Title:                           
             
	   	 	 	 	 
	Address: 	 	1900 East Ninth Street	 	NATIONAL CITY BANK
	 	 	Cleveland, Ohio 44114	 	 
	 	 	Attention: Large Corporate	 	By:                            
              
	 	 	Banking Division	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address: 	 	250 West Huron 	 	THE CHASE MANHATTAN BANK
	 	 	Cleveland, Ohio 44113	 	 
	 	 	Attention: Large Corporate	 	By:                            
              
	 	 	Banking Division 	 	Name:                           
           
	 	 	 	 	Title:                           
             

	Address: 	 	1404 East Ninth Street 	 	FIFTH THIRD BANK, NORTHEASTERN
	 	 	Cleveland, Ohio 44114 	 	OHIO
	 	 	Attention: Large Corporate	 	 
	 	 	Banking Division	 	By:                            
              
	 	 	 	 	Name:                           
           
	 	 	 	 	Title:                           
             
	   	 	 	 	 
	Address:	 	1350 Euclid Avenue 	 	FIRSTAR BANK, NATIONAL 
	 	 	Cleveland, Ohio 44115 	 	ASSOCIATION
	 	 	Attention: Large Corporate	 	 
	 	 	Banking Division	 	By:                            
              
	 	 	 	 	Name:                           
           
	 	 	 	 	Title:                           
             
	  	 	 	 	 
	Address: 	 	244 Westchester Avenue 	 	FLEET NATIONAL BANK
	 	 	White Plains, New York 10604	 	 
	 	 	Attention: Large Corporate	 	By:                          
                
	 	 	Banking Division	 	Name:                           
           
	 	 	 	 	Title:                           
             
	   	 	 	 	 
	Address: 	 	110 South Stratford Road 	 	BRANCH BANKING & TRUST CO.
	 	 	Suite 301	 	 
	 	 	Winston-Salem, NC 27104	 	By:                            
              
	 	 	Attention: Large Corporate	 	Name:                           
           
	 	 	Banking Division 	 	Title:                           
             

 

ACKNOWLEDGMENT OF GUARANTORS

        Each of the undersigned consents and agrees to and acknowledges the terms of the foregoing Amendment No. 1 to Credit Agreement and Waiver. Each of
the undersigned further agrees that the obligations of each of the undersigned pursuant to the Guaranty of Payment, the Security Agreement and any other Loan Document to which any of the undersigned is a party shall remain in full force and effect
and be unaffected hereby.

	 	ONCO Investment Company
	 	Oglebay Norton Industrial Minerals, Inc.
	 	Oglebay Norton Management Company
	 	Oglebay Norton Industrial Sands, Inc.
	 	Oglebay Norton Terminals, Inc.
	 	Oglebay Norton Engineered Materials Inc.
	 	Michigan Limestone Operations, Inc.
	 	Global Stone Corporation (successor by merger to
	 	 	Oglebay Norton Acquisition Company)
	 	Global Stone Tenn Lutrell Company
	 	Global Stone Chemstone Corporation
	 	Global Stone St. Clair, Inc.
	 	Global Stone Filler Products Company
	 	Global Stone James River, Inc.
	 	GS PC, Inc.
	 	Oglebay Norton Minerals, Inc.
	 	Oglebay Norton Specialty Minerals, Inc.
	 	ON Marine Services Company
	  	 	 	 	 
	 	By:  
 
	 	 	Rochelle F. Walk, as Vice President and

Secretary of each of the companies listed

above.
	  	 	 	 	 
	 	Texas Mining, LP, by its General Partner
	 	  Oglebay Norton Industrial Sands, Inc.
	 	  	 	 	 
	 	 	By: 
 
	 	 	 	Rochelle F. Walk 
	 	 	 	Vice President and Secretary
	 	 	 	 	 
	 	Global Stone PenRoc LP, by its General Partner,

GS PC, Inc,.
	  	 	 	 	 
	 	 	By: 
 
	 	 	 	Rochelle F. Walk, 
	 	 	 	Vice President and Secretary 
	 	 	 	 	 
	 	Oglebay Marine Services Company, L.L.C., by its

Member OM MARINE SERVICES COMPANY
	 	 	 	 	 
	 	 	By: 
 
	 	 	 	Rochelle F. Walk
	 	 	 	Vice President and Secretary

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