Document:

EX-10.1

 Exhibit 10.1 

PURETECH HEALTH PLC 

PERFORMANCE SHARE PLAN 
  

	1.	 Establishment, Purpose and Types of Awards 

Puretech Health plc, a public limited company incorporated under English law (the “Company”), hereby establishes the PURETECH
HEALTH PLC PERFORMANCE SHARE PLAN (the “Plan”). The purpose of the Plan is to promote the long-term growth and profitability of the Company by (i) providing key individuals with incentives to improve shareholder value and to
contribute to the growth and financial success of the Company through their future services, and (ii) enabling the Company to attract, retain and reward the necessary talent. 

The Plan permits the granting of share options (including incentive share options qualifying under Code section 422 and nonstatutory share
options), share appreciation rights, restricted or unrestricted share awards, restricted share units, performance awards, other share-based awards, or any combination of the foregoing. 

 

	2.	 Definitions 

Under this Plan, except where the context otherwise indicates, the following definitions apply: 

(a) “Administrator” means the remuneration committee of the Board or a committee(s) or officer(s) appointed by
the remuneration committee that have authority to administer the Plan as provided in Section 3 hereof, provided that in relation to any director of the Company or any amendment to the Plan, the Administrator shall be the remuneration committee.

 (b) “Adoption Date” means the date on which the Plan is approved by shareholders in general meeting or by
written resolution. 
 (c) “Affiliate” means any entity, whether now or hereafter existing, which is a
Subsidiary of the Company (as defined in section 1159 Companies Act 2006). 
 (d) “Award” means any share
option, share appreciation right, share award, restricted share unit award, performance award, or other share-based award granted under the Plan. 

(e) “Board” means the Board of Directors of the Company. 

(f) “Cause” has the meaning ascribed to such term or words of similar import in the grantee’s written
employment or service contract with the Company or Affiliate as in effect at the time of issue and, in the absence of such agreement or definition means the grantee’s (i) material failure to perform his duties to the Company or any
Affiliate (other than any such failure resulting from incapacity due to physical or mental illness) that would reasonably be expected to result in material injury to the Company and/or any Affiliate; (ii) failure to comply with any material,
valid and legal directive of the grantee’s supervisor or of the Board; (iii) engagement in dishonesty, illegal conduct or misconduct, which is, in each case, materially injurious to the Company and/or any Affiliate; (iv) embezzlement,
or misappropriation of funds or property of the Company or any Affiliate (other than occasional and de minimis use of Company or Affiliate property for personal purposes), in each case related to the grantee’s service with the Company or
Affiliate; (v) conviction of or plea of guilty or nolo contendere to a crime that constitutes (A) a felony (or state law equivalent), or a crime that constitutes (B) a misdemeanor involving moral turpitude or fraud that would
reasonably be expected to result in material injury or reputational harm to the Company and/or any Affiliate; (vi) material violation of a material written policy of the Company or any Affiliate; (vii) willful unauthorized disclosure of
confidential information of the Company or any Affiliate; or (viii) material breach of any material obligation under any other written agreement between the grantee and the Company and/or any Affiliate which is likely to be materially injurious
to the Company and/or any Affiliate; provided, that Cause shall not include any matter otherwise falling within sub-paragraphs (i), (ii), (vi) or (viii) of the above definition unless the grantee shall
have been given during the term of his or her employment thirty (30) days from the delivery of written notice by the Company within which to cure any acts, failures, breaches or refusal within those
sub-paragraphs, except for an act, failure, breach or refusal which, by its nature, cannot reasonably be expected to be cured. 

 (g) “Control” has the meaning given in
section 1124 Corporation Taxes Act 2010 and “Control” shall be construed accordingly. 

(h) “Code” means the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder.

 (i) “Dealing Restrictions” means any restrictions imposed by the Model Code on Directors’ Dealings
in securities as set out in the Annex to Chapter 9 of the UK Listing Authority’s Listing Rules, and/or such other rules, regulations or internal dealing code adopted by the Company which govern dealing in Shares, interests in Shares, options or
rights over Shares or interests in Shares. 
 (j) “Dividend Equivalent” means an amount equal to the net
amount of any dividend paid in respect of Shares during the period over which Shares Vest. 
 (k) “Executive
Directors” means the executive directors of the Company; 
 (l) “Fair Market
Value” means, with respect to the Shares, as of any date: 
 (i) if the principal market for the
Shares (as determined by the Board if the Shares are listed or admitted to trading on more than one exchange or market) is a national securities exchange or an established securities market, the official closing price per share for the regular
market session on that date on the principal exchange or market on which the Shares are then listed or admitted to trading or, if no sale is reported for that date, on the last preceding day for which a sale was reported; 

(ii) if the principal market for the Shares is not a national securities exchange or an established securities market, the
average of the highest bid and lowest asked prices for the Shares on that date as reported on a national quotation system or, if no prices are reported for that date, on the last preceding day for which prices were reported; or 

(iii) if the Shares are neither listed or admitted to trading on a national securities exchange or an established securities
market, nor quoted by a national quotation system, the value determined by the Board in good faith by the reasonable application of a reasonable valuation method. 

(m) “Grant Agreement” means a written document, in the terms of a deed between the Company, the employing
company (if different) and the grantee to whom the Award is granted and in a form determined by the Administrator which effects the grant of the Award and which sets out the terms and conditions of the Award and which shall incorporate the terms of
the Plan. 
 (n) “Gross Misconduct” means the grantee’s (i) material failure to perform his duties
to the Company or any Affiliate (other than any such failure resulting from incapacity due to physical or mental illness) that would reasonably be expected to result in material injury to the Company and/or any Affiliate; (ii) engagement in
dishonesty, illegal conduct or misconduct, which is, in each case, materially injurious to the Company and/or any Affiliate; (iii) embezzlement, or misappropriation of funds or property of the Company or any Affiliate (other than occasional and
de minimis use of Company or Affiliate property for personal purposes), in each case related to the grantee’s service with the Company or Affiliate; (iv) conviction of or plea of guilty or nolo contendere to a crime that constitutes
(A) a felony (or state law equivalent), or a crime that constitutes (B) a misdemeanor involving moral turpitude or fraud that would reasonably be expected to result in material injury or reputational harm to the Company and/or any
Affiliate; (v) willful unauthorized disclosure of confidential information of the Company or any Affiliate; or (vi) material breach of any material obligation under any other written agreement between the grantee and the Company and/or any
Affiliate which is likely to be materially injurious to the 

  
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Company and/or any Affiliate; provided, however, that Gross Misconduct shall not be deemed to have occurred unless the grantee shall have been given during the term of his or her employment
thirty (30) days from the delivery of written notice by the Company within which to cure any acts constituting Gross Misconduct, except for a failure, breach or refusal which, by its nature, cannot reasonably be expected to be cured. 

(o) “Option Exercise Period” means the period commencing on the date of Vesting of an Option and ending on the
day before the tenth anniversary of grant or such earlier date as may be specified by the Administrator at the date of grant and stated in the Grant Agreement. 

(p) “Performance Condition” means any performance condition imposed in relation to an Award pursuant to
Section 7(a)(iii) of the Plan and “Performance Period” means the period over which such Performance Condition is measured. 

(q) “Section 409A” means Code section 409A and the Treasury regulations and other official guidance
thereunder. 
 (r) “Share” or “Shares” means a share or shares of the Company’s
ordinary share capital. 
 (s) “Termination Date” means the day immediately preceding the tenth anniversary
of the Adoption Date. 
 (t) “Vesting” means, in relation to an option, the option becoming exercisable and
in relation to any other Award, the Grantee becoming entitled to have the Shares (or cash, as the case may be) transferred to him subject to the Plan. 
  

	3.	 Administration 

(a) Administration of the Plan. The Plan shall be administered by the Board or by such committee or committees as may be
appointed by the Board from time to time. To the extent allowed by applicable law, the Board by resolution may authorize an officer or officers to grant Awards to other officers and employees of the Company and its Affiliates, and, to the extent of
such authorization, such officer or officers shall be the Administrators provided that any Award to be granted to an Executive Director shall be approved by a Committee comprising non-executive directors of
the Company. 
 (b) Powers of the Administrator. The Administrator shall have all the powers vested in it by the terms
of the Plan, such powers to include authority, in its sole and absolute discretion, to grant Awards under the Plan, prescribe Grant Agreements evidencing such Awards and establish programs for granting Awards. 

The Administrator shall have full power and authority to take all other actions necessary to carry out the purpose and intent
of the Plan, including, but not limited to, the authority to do any of the following but only to the extent not inconsistent with the terms of the Plan: (i) determine the eligible persons to whom, and the time or times at which Awards shall be
granted; (ii) determine the types of Awards to be granted; (iii) determine the number of shares to be covered by or used for reference purposes for each Award; (iv) impose such terms, limitations, restrictions and conditions upon any
such Award as the Administrator shall deem appropriate including Performance Conditions; (v) subject to Section 10(e) modify, amend, extend or renew outstanding Awards, or accept the surrender of outstanding Awards and substitute new
Awards; provided, however, that, except as otherwise permitted under Section 10(c) of the Plan, any modification, amendment, extension, renewal or substitution that would materially adversely affect any outstanding Award shall not be made
without the consent of the holder, but if any of the foregoing actions results in a change in the tax consequences with respect to an Award such change shall not be considered to materially adversely affect the Award; and (vi) for any purpose,
including but not limited to, qualifying for preferred tax treatment under foreign tax laws or otherwise complying with the regulatory requirements of local or foreign jurisdictions, to establish, amend, modify, administer or terminate sub-plans, and prescribe, amend and rescind rules and regulations relating to such sub-plans provided that the terms, rules and regulations of the sub-plans are not inconsistent with the terms of the Plan.  

  
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 The Administrator shall have full power and authority, in its sole and
absolute discretion, to administer, construe and interpret the Plan, Grant Agreements and all other documents relevant to the Plan and Awards issued thereunder, to establish, amend, rescind and interpret such rules, regulations, agreements,
guidelines and instruments for the administration of the Plan and for the conduct of its business as the Administrator deems necessary or advisable, and to correct any defect, supply any omission or reconcile any inconsistency in the Plan or in any
Award in the manner and to the extent the Administrator shall deem it desirable to carry it into effect. 
 (c) Non-Uniform Determinations. The Administrator’s determinations under the Plan (including without limitation, determinations of the persons to receive Awards, the form, amount and timing of such Awards, the
terms and provisions of such Awards, and the Grant Agreements evidencing such Awards) need not be uniform and may be made by the Administrator selectively among Awards or persons who receive, or are eligible to receive, Awards under the Plan,
whether or not such persons are similarly situated. 
 (d) Effect of Administrator’s Decision. All actions taken
and decisions and determinations made by the Administrator on all matters relating to the Plan pursuant to the powers vested in it hereunder shall be in the Administrator’s sole and absolute discretion and shall be conclusive and binding on all
parties concerned, including the Company, its shareholders, any participants in the Plan and any other employee, consultant, or director of the Company, and their respective successors in interest. 

(e) Determination of terms of Awards to Executive Directors. When determining the terms of any proposed Award to an
Executive Director, the Administrator shall have regard to the current directors’ remuneration policy as described in the Company’s Report and Accounts. 
  

	4.	 Limits on Shares available under the Plan 

(a) Overall Plan Limits 

(i) No Award may be granted on any date if, as a result, the number of Shares issued or capable of being issued in respect of
Awards granted under the Plan or awards granted under any other share plan operated by the Company, in each case granted during the ten year period ending on that date, would exceed 10 per cent of the Company’s Shares in issue immediately
before that date. 
 (ii) No Award may be granted on any date if, as a result, the number of Shares issued or capable of
being issued in respect of Awards granted under the Plan or awards granted under any other share plan operated by the Company in each case to directors, executive officers, senior managers or senior service providers, in each case granted during the
ten year period ending on that date, would exceed 5 per cent of the Company’s Shares in issue immediately before that date. 

(iii) For the purposes of this section 4(a): 

(A) Awards which have lapsed or been released shall not be counted; 

(B) Awards granted under any other share plan or share incentive arrangement prior to Admission shall not be counted; 

(C) references to any issue or prospective issue of Shares by the Company shall include a transfer of Treasury Shares but only
for so long as (and to the extent that) the guidelines issued by the Association of British Insurers for share incentive schemes specify that Treasury Shares should be so included; and 

  
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 (D) whether an individual is a senior manager or senior service provider
shall be determined by the Administrator acting reasonably. 
 (iv) Notwithstanding (i) above, no more than an
aggregate of 22,724,800 Shares may be issued pursuant to incentive share options intended to qualify under Code section 422. 

(b) Individual Limit 

The maximum total Market Value of Shares in respect of which an Award may be granted to a grantee in any financial year of the
Company shall be 400 per cent. of his annual base salary (excluding benefits in kind) for that financial year (or for the preceding financial year, if greater). Base salary in a currency other than sterling will be converted into sterling by
using any rate of exchange which the Administrator may reasonably select. 
 An Award may be granted in excess of this limit
if circumstances arise which the Administrator deems sufficiently exceptional to justify it which may include, without limitation, an Award to an individual who is a new hire in the financial year in question. 

For these purposes, Market Value in respect of a Share on any date means the value equal to the closing middle market quotation
of that Share as derived from the Daily Official List of the London Stock Exchange plc for the dealing day immediately preceding that date or, if the Administrator so determines, the average of such closing middle market quotation of a Share for the
three dealing days immediately preceding that date. 
 (c) Effect of limits 

Any Award shall be limited and take effect so that the limits in this section 4 are complied with. 

If any Award, or portion of an Award, under the Plan expires or terminates unexercised, becomes unexercisable, is settled in
cash without delivery of Shares, or is forfeited or otherwise terminated, surrendered or canceled as to any Shares, or if any Shares are repurchased by or surrendered to the Company in connection with any Award, or if any Shares are withheld by the
Company, the Shares subject to such Award and the repurchased, surrendered and withheld Shares shall thereafter be available for further Awards under the Plan. 
  

	5.	 Participation 

Participation in the Plan shall be open to all employees, officers, and directors of, and other individuals providing bona fide services to or
for, the Company, or of any Affiliate of the Company, as may be selected by the Administrator from time to time. The Administrator may also grant Awards to individuals in connection with hiring, recruiting or otherwise, prior to the date the
individual first performs services for the Company or an Affiliate, provided that such Awards shall not become vested or exercisable, and no shares shall be issued to such individual, prior to the date the individual first commences performance of
such services. 
  

	6.	 Timing of Awards 

Awards may only be granted within 42 days starting on any of the following: 

(a) the date of shareholder approval of the Plan; 

(b) the day after the announcement of the Company’s results for any period; 

  
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 (c) any day on which the Administrator resolves that exceptional
circumstances exist which justify the grant of Awards, which may include, without limitation, a day on which the Administrator determines that it would be appropriate to make an award to an individual who is a new hire since the last period within
section 6(a) or (b) above closed; 
 (d) any day on which changes to legislation or regulations affecting share plans
are announced, effected or made; or 
 (e) the date of the lifting of Dealing Restrictions which prevented the granting of
Awards during any period specified above. 
 Awards may not be granted at any time after the Termination Date. 

 

	7.	 Awards 

(a) General 
 (i)
The Administrator shall, in its sole discretion, determine the terms of all Awards granted under the Plan. Awards may be granted individually or together with other types of Award, concurrently with or with respect to outstanding Awards. 

(ii) Awards are subject to the rules of the Plan. An Award must be granted by a Grant Agreement which shall state (1) the type of Award
which is thereby granted; (2) the date on which the Award is granted; (3) the number of Shares subject to the Award or the basis on which the number of Shares subject to the Award will be calculated; (4) any Performance Condition;
(5) any other condition specified under Section 7(a)(iv); (6) the date of Vesting (which shall not be later than the day before the tenth anniversary of grant); (7) whether the Participant is entitled to receive any Dividend Equivalent;
(8) if relevant, the price at which the Shares may be acquired pursuant to the Award and (9) the terms of any recovery and withholding provisions imposed pursuant to section 7(f). 

(iii) The Vesting of an Award may (and shall in the case of grantees who are Executive Directors) be conditional upon the satisfaction of one
or more conditions linked to performance. A Performance Condition must be specified at the date of grant of the Award. The Administrator may waive or change a Performance Condition in accordance with its terms or if anything happens which causes the
Administrator reasonably to consider it appropriate to do so, provided that any amended Performance Condition will represent a fairer measure of performance and will be no more difficult nor easy to satisfy than the original Performance Condition
but for the event in question. 
 (iv) The Administrator may impose other conditions when granting an Award. Any condition must be specified
at the Award Date and may provide that an Award will lapse if it is not satisfied. The Administrator may waive or, provided it is not to the grantee’s detriment, change a condition imposed under this Section 7(a)(iv). 

(v) A grantee is not required to pay for the grant of an Award. 

(vi) The Administrator may agree with the trustee of any trust set up for the benefit of grantees that any Award granted by the Administrator
shall be satisfied by the trustee of such trust. 
 (b) Types of Award 

Awards granted under the Plan may take any of the following forms: 

(i) Share Options. The Administrator may from time to time grant to eligible participants Awards of US incentive share
options as that term is defined in Code section 422 or nonstatutory or non-approved share options; provided, however, that Awards of US incentive share options shall be limited to employees
of the Company or of any current or hereafter existing “parent corporation” or “subsidiary corporation,” as defined in Code sections 424(e) and (f), respectively, of the Company and

  
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any other individuals who are eligible to receive incentive share options under the provisions of Code section 422. Options intended to qualify as incentive share options under Code
section 422 must have an exercise price at least equal to Fair Market Value as of the date of grant, but nonstatutory or non-approved share options may be granted with an exercise price less than Fair
Market Value if drafted in a manner intended to comply with Section 409A (if the Code will be applicable to that option). No share option shall be an incentive share option unless so designated by the Administrator at the time of grant or in
the Grant Agreement evidencing such share option. 
 (ii) Share Appreciation Rights. The Administrator may from time
to time grant to eligible participants Awards of Share Appreciation Rights (“SAR”). A SAR entitles the grantee to receive, subject to the provisions of the Plan and the Grant Agreement, a payment having an aggregate value equal to
the product of (i) the excess of (A) the Fair Market Value on the exercise date of one Share over (B) the base price per share specified in the Grant Agreement, times (ii) the number of Shares specified by the SAR, or portion
thereof, which is exercised. The base price per share specified in the Grant Agreement shall not be less than the lower of the Fair Market Value on the grant date or the exercise price of any tandem share option Award to which the SAR is related. No
SAR shall have a term longer than ten years’ duration. Payment by the Company of the amount receivable upon any exercise of a SAR may be made by the delivery of Shares or cash, or any combination of Shares and cash, as determined in the sole
discretion of the Administrator. If upon settlement of the exercise of a SAR a grantee is to receive a portion of such payment in shares of Shares, the number of shares shall be determined by dividing such portion by the Fair Market Value of a share
of Shares on the exercise date. No fractional Shares shall be used for such payment and the Administrator shall determine whether cash shall be given in lieu of such fractional shares or whether such fractional shares shall be eliminated. 

(iii) Share Awards. The Administrator may from time to time grant restricted or unrestricted share Awards to eligible
participants in such amounts, on such terms and conditions, and for such consideration, including no consideration or such minimum consideration as may be required by law, as it shall determine. A share Award may be paid in Shares, in cash, or in a
combination of Shares and cash, as determined in the sole discretion of the Administrator. 
 (iv) Restricted Share
Units. The Administrator may from time to time grant Awards to eligible participants denominated in share-equivalent units or restricted share units in such amounts and on such terms and conditions as it shall determine. Share equivalent or
restricted share units granted to a participant shall be credited to a bookkeeping reserve account solely for accounting purposes and shall not require a segregation of any of the Company’s assets. An Award of share-equivalent or restricted
share units may be settled in Shares, in cash, or in a combination of Shares and cash, as determined in the sole discretion of the Administrator. Except as otherwise provided in the applicable Grant Agreement, the grantee shall not have the rights
of a shareholder with respect to any Shares represented by a share-equivalent or restricted share unit solely as a result of the grant of a share-equivalent or restricted share unit to the grantee. 

(v) Other Share-Based Awards. The Administrator may from time to time grant other share-based awards to eligible
participants in such amounts, on such terms and conditions, and for such consideration, including no consideration or such minimum consideration as may be required by law, as it shall determine. Other share-based awards may be denominated in cash,
in Shares or other securities, in share-equivalent units, in share appreciation units, in securities or debentures convertible into Shares, or in any combination of the foregoing and may be paid in Shares or other securities, in cash, or in a
combination of Shares or other securities and cash, all as determined in the sole discretion of the Administrator. 
 (c) Vesting of Awards

 (i) Testing of Performance Conditions. As soon as reasonably practicable after the end of the Performance Period,
the Administrator will determine whether and to what extent any Performance Condition or other condition imposed under Section 7(a)(iv) has been satisfied or waived and how many Shares will accordingly Vest for each Award. 

  
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 (ii) Timing of Vesting—Award not subject to Performance
Condition. Where an Award is not subject to a Performance Condition, then subject to Sections 7(a)(iv), 8 and 9, an Award Vests on the date of Vesting specified at the time of grant of the Award or, if on that date a Dealing Restriction applies
to that Award, the first date on which it ceases to apply. 
 (iii) Timing of Vesting—Award subject to Performance
Condition. Where an Award is subject to a Performance Condition, then subject to Rules 7(a)(iv), 8 and 9, an Award Vests, to the extent to which the Performance Condition has been satisfied, on the date on which the Administrator makes its
determination under Section 7(c)(i) or, if on that date a Dealing Restriction applies to that Award, the first date on which it ceases to apply. 

(iv) Dividend Equivalents. An award may include the right to a Dividend Equivalent (which may be paid in cash or Shares)
(at the determination of the Administrator). Dividend Equivalents shall only be payable in respect of Shares which Vest and shall be paid at the time at which the Vested Award is satisfied. 

(d) Lapse 
 To the extent that
any Award does not Vest, it shall forthwith lapse on the date on which and to the extent to which it is no longer capable of Vesting. Where an Award lapses, the grantee shall cease to have any rights in respect of it. 

(e) Consequences of Vesting 

(i) Awards other than options. As soon as reasonably practicable after Vesting but in any event within 30 days of
Vesting, the Company will use reasonable endeavours to arrange (subject to sections 10(a) and (h)) for the issue or transfer (including a transfer from treasury) to or to the order of the grantee of the number of Shares in respect of which the Award
has Vested. 
 (ii) Options 

(A) A grantee may exercise his option at any time during the Option Exercise Period (unless it lapses pursuant to Sections 8
or 9) following Vesting by giving notice in the prescribed form to the Company and paying the option exercise price (if any). The option will lapse at the end of the Option Exercise Period to the extent not then exercised. 

(B) As soon as reasonably practicable following exercise of an option (but subject to Sections 10(a) and (h), but in any event
within 30 days of the date on which the option is exercised, the Company will use reasonable endeavours to arrange for Shares to be transferred to or issued to, or to the order of, the participant. 

(C) If an option Vests under more than one provision of the rules of the Plan, the provision resulting in the earliest Vesting
applies. 
 (iii) Share rights. 

(A) Subject to the terms upon which any restricted share awards are granted, Shares transferred or issued on Vesting or (as
the case may be) exercise of Award shall rank pari passu in all respects with the Company’s existing Shares, save that they shall not carry the right to dividends or other distributions declared or recommended the record date for which falls
prior to the date when the Award Vested or, in the case of an option, was exercised. 
 (B) If and so long as the Shares are
listed and traded on a public market, the Company will apply for listing of any Shares issued under the Plan as soon as practicable. 

  
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 (f) Recovery and withholding 

(i) Applicability of recovery and withholding provisions 

Awards may be granted on terms that the Administrator may, at any time in the period of three years following Vesting of the Award (or such
shorter period as the Administrator may determine) decide that the grantee to whom an Award was granted shall be obliged to repay an amount determined in accordance with Section 7(f)(ii). if the Administrator reasonably determines that any of
the following circumstances apply: 
 (A) discovery of a material misstatement in the audited consolidated accounts of the
Company or the audited accounts of any Affiliate; 
 (B) the assessment of any Performance Condition and/or any other
condition imposed in respect of an Award was based on an , or inaccurate or misleading information or assumptions; and/or 

(C) action or conduct of the participant prior to the date of Vesting of the Award which, in the reasonable opinion of the
Administrator amounts to fraud or gross misconduct or has had a materially detrimental effect on the reputation of the Company or any Affiliate and which in either case would have entitled the Company or any Affiliate to dismiss the grantee for
Gross Misconduct. 
 For the avoidance of doubt, any reduction under this Section 7(f) may be applied on an individual
basis as determined by the Administrator. 
 (ii) Amount subject to recovery and withholding 

The Administrator shall determine the amount which a grantee is obliged to repay in accordance with Section 7(f)(i) which
shall be (i) in the case of (A) and (B) above, all or part of the additional value of which the Administrator considers would not have Vested under the Award had the misstatement not been made and/or had the Performance Condition been
assessed on a correct basis, or in the case of (C) all or part of the value of the Award which would not have Vested had the employment been terminated in accordance with such misconduct, provided that the Administrator may determine that the
amount which shall be repaid shall take into account any tax or social security contributions incurred by the grantee in relation to the Vesting of the Award and/or on subsequent sale of the Shares acquired. 

(iii) Satisfaction of recovery and withholding 

The Administrator may determine that the grantee’s obligation to repay amounts pursuant to Section 7(f) shall be
satisfied at any time following the determination under Section 7(f)(ii) in one or more of the following ways: 
 (A)
reduction of the number of Shares subject to any subsisting Award granted under the Plan or any subsisting award granted under any other share plan or share award agreement notwithstanding the extent to which any performance condition and/or any
other condition imposed on such Award and/or other award (as relevant) has been satisfied; 
 (B) reduction of any future
bonus which would otherwise be payable to the grantee; 
 (C) payment of any amount by the grantee on such terms as the
Administrator may direct (including but without limitation to, on terms that the relevant amount is to be deducted from the grantee’s salary or from any other payment to made to the grantee by the Company or any Affiliate). 

  
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 (iv) Reduction in Awards to give effect to recovery and withholding in
other plans 
 The Administrator may decide at any time to reduce the number of Shares subject to an Award (including, if
appropriate, reducing to zero) to give effect to recovery and withholding provisions of any form and/or name contained in any incentive plan or any bonus plan operated by the Company. The value of the reduction shall be in accordance with the terms
of the relevant provisions of the relevant plan or, in the absence of any such term, on such basis as the Administrator and reasonably decides is appropriate. 
  

	8.	 Leavers 

  

	 	(a)	 General 

(i) Unless Section 8(b) applies, an Award which has not Vested will lapse on the date on which the grantee ceases to be an
employee, officer or director of, or to provide services to the Company or any Affiliate (“Cessation”). 
 (ii) An
Award which has Vested on the date of Cessation may be retained or exercised (as the case may be) by the grantee subject to and in accordance with the terms of the Plan save that if an employee or officer or director is dismissed for Cause: 

(A) all Vested but not yet exercised options shall also forthwith lapse on Cessation; and 

(B) all types of Vested Award shall be subject to such recovery and withholding provisions as the Administrator considers
appropriate and which shall be set out in the relevant Grant Agreement. 
  

	 	(b)	 Good leavers 

If the Cessation is as a result of : 
  

	 	(i)	 the grantee’s death or disability; 

 

	 	(ii)	 the grantee’s service being terminated by the Company or any Affiliate without Cause; or

  

	 	(iii)	 any other reason determined by the Administrator (subject to such determination not resulting in the relevant
Award terms breaching Section 409A) 

 before the date on which the Award Vests, then such Award shall not lapse but,
subject to this Section 8 and Section 9 shall continue in force and Vest as if the Cessation had not occurred, subject to any terms specified in the Grant Agreement, unless (and subject to such determination not breaching
Section 409A) the Administrator determines that the Award may Vest in such circumstances on the date of Cessation or such other date set forth in the Grant Agreement. 
  

	 	(c)	 Number of Shares Vesting 

Where Section 8(b) applies, the number of Shares in respect of which an Award shall Vest shall be determined as follows: 

 

	 	(i)	 the Administrator shall determine the extent to which any Performance Condition applicable to that Award has
been satisfied at the time of Vesting; and 

  

	 	(ii)	 the resulting number of Shares so calculated shall then be reduced on a pro rata basis based on the number of
days from beginning of the Performance Period applicable to that Award (or, where there is no Performance Period, the date of grant of the Award) until Cessation pro- rata to the original Performance Period
(or, where there is no Performance Period, the original Vesting period applicable to the Award), and the resulting figure, rounded up to the nearest whole number of Shares shall be the number of Shares which Vest, provided that the
Administrator may in its discretion determine that exceptional circumstances exist which justify Vesting to a greater extent than the pro-rating referred to in this section 8(c)(ii) would allow, and

  
 - 10 - 

	 	
provided further that if a Cessation has occurred but before Vesting of the Award has occurred in accordance with section 8(b), a Specified Event occurs, the extent to which the Award
Vests shall be the number calculated in accordance with section 9(a)(ii)(A)(a)or the proviso to section 9(a)(ii)(A) (as the case may be) as reduced by the pro-rating referred to in section 8(c)(ii) above).

  

	 	(d)	 Time period for exercise of option 

Where an option Vests in accordance with Section 8(b), or has already Vested at the date of Cessation, subject to Section 9 it may
be exercised during the period of 6 months beginning on the date of Vesting (or such other period specified by the Administrator in the Grant Agreement or within 30 days of Cessation), but no later than the last day of the Option Exercise Period and
to the extent not so exercised, shall lapse. 
  

	 	(e)	 Meaning of Cessation 

Any reference to a Cessation in this Section 8 will not include a Cessation where the grantee ceases to be employed by, or to be an
officer or director of, or to provide services to, the Company or any Affiliate (as the case may be) and immediately commences to be employed by, or to be an officer or director of or to provide services to the Company or any other Affiliate (as the
case may be). In respect of any payments under an Award that are payments of deferred compensation subject to Section 409A, Cessation shall mean the grantee’s “separation from service” as defined in Section 409A, if
necessary to comply with Section 409A. 
  

	9.	 Change of Control and other corporate events 

 

	(a)	 Change of control, compromise or arrangement and winding up 

 

	 	(i)	 Specified events 

In respect of any Award that has not lapsed, if one of the following events (“Specified Events”) occurs, then such Award
shall Vest on such Specified Event subject to and as specified in this Section 9(a). 
 (A)
              any person (or group of persons acting in concert) obtains Control of the Company as a result of making a general offer to acquire Shares; 

 

	 	(B)	 any person becomes bound or entitled to acquire Shares under sections 979 to 982 (inclusive) of the Companies
Act 2006; 

  

	 	(C)	 the court sanctions a compromise or arrangement in relation to the Company pursuant to section 899 of the
Companies Act 2006 in connection with or for the purposes of a change in Control of the Company; or 

  

	 	(D)	 the Company gives notice of a general meeting at which a resolution is to be proposed for the voluntary winding
up of the Company. 

 Notwithstanding the foregoing, the Administrator may specify a different definition of change of
Control or Specified Event in the Grant Agreement if necessary or advisable to comply with Section 409A, provided that any such different definition shall as closely as is possible follow the relevant definition of “Specified Event”
above. 

  
 - 11 - 

	 	(ii)	 Extent to which Award Vests 

 

	 	(A)	 The extent to which an Award Vests upon the Specified Event shall be determined as follows:

  

	 	(a)	 the Administrator shall determine the extent to which, in its reasonable opinion, the Performance Condition
applicable to that Award has been satisfied at that time and shall calculate the number of Shares in respect of which the Award would be capable of Vesting accordingly; and 

 

	 	(b)	 unless the Administrator determines not to apply such pro-rating and to
allow Vesting to a greater extent, the resulting number of Shares so calculated shall then be reduced on a pro rata basis based on the number of days from the beginning of the Performance Period applicable to that Award (or, where there is no
Performance Period, the date of grant of the Award) until the date of the Specified Event pro rata to the Performance Period (or, where there is no Performance Period, the original Vesting period applicable to that Award) and the resulting figure,
rounded up to the nearest whole number of Shares shall be the number of Shares in respect of which the Award shall vest 

To the extent that the Award does not Vest in accordance with this Section 9(a)(ii), and subject to Sections 9(a)(iii) to (v) below,
the Award shall forthwith lapse on the occurrence of the Specified Event. 
  

	 	(iii)	 Mandatory exchange of Awards 

Notwithstanding Section 9(a)(i), if an event within Section 9(a)(i) will result in another company acquiring Control of the Company
and such other company agrees to offer replacement share awards, the Administrator may determine, if in its absolute discretion it is satisfied that the circumstances are exceptional, that it is not appropriate on the occurrence of such event for
any part of the outstanding Awards to Vest and that instead outstanding Awards shall be released in consideration of the award of replacement options over shares or share awards in the acquiring company subject to and in compliance with Code
sections 409A and 424. 
  

	 	(iv)	 Exchange of Awards 

If the Specified Event is one referred to in Section 9(a)(i)(A) to (C), the Administrator may within the appropriate period and with the
agreement of any company that obtains Control of the Company and with the agreement of the grantee and subject to and in compliance with Code sections 409A and 424, vary the terms of the Award made to the grantee or facilitate the exchange of the
Award for a new award made by the acquiring company which may operate over shares in the acquiring company. In this section 9(a)(iv), “appropriate period” means: 

 

	 	(A)	 where the Specified Event is one within section 9(a)(i)(A) or (B), the period specified in section 9(a)(v)(A)
or (B) respectively; 

  

	 	(B)	 where the Specified Event is one within section 9(a)(i)(C), the period of six months beginning with the
time when the Court sanctions the scheme of arrangement. 

  
 - 12 - 

	 	(v)	 Period for exercise 

In the case of an Award which is in the form of an option, where a Specified Event occurs any outstanding Option must be exercised (if at
all): 
  

	 	(A)	 where the event in question is within section 9(a)(i)(A) and where section 9(a)(i)(B) does not apply, within
the period beginning on the date on which the grantee receives notification of the offer from the Board and ending 30 days after the time when the person making the offer has obtained Control of the Company and any condition subject to which the
offer is made is satisfied (provided that any exercise prior to the other person(s) obtaining Control shall take effect immediately prior to that other person actually obtaining Control); 

 

	 	(B)	 where the event in question is within section 9(a)(i)(B), within the period during which the person remains so
bound or entitled; 

  

	 	(C)	 where the event in question is within section 9(a)(i)(C), during the period which starts on the date on which
the Court sanctions the compromise, or arrangement and ends six months later or, if earlier, on the day immediately preceding the date upon which the compromise or arrangement becomes effective; 

 

	 	(D)	 where the event in question is within section 9(a)(i)(D), at any time prior to the commencement of such winding
up (any such exercise to take effect immediately prior to the commencement of the winding up) 

 and to the extent not so
exercised the Option shall lapse. 
  

	(b)	 Demergers, reconstructions and other corporate events 

On the occurrence of any demerger, reorganisation, reconstruction or amalgamation, distribution or other transaction of the Company, which in
the reasonable opinion of the Administrator may affect the value of any Award, the Administrator may vary or alter in any manner which it considers appropriate the terms of any Award to prevent enlargement or diminution of the grantee’s rights
or benefits under the Award. 
 Such alteration may include (without limitation), amending the Performance Condition, the terms on which an
Award Vests (and may provide for immediate Vesting on such event) and altering the terms of an Award such that the Award is over shares in another company, subject to and in compliance with Section 409A, or terminating and paying out the Award
pursuant to Treasury Regulation section 1.409A-3(j)(4). 
  

	10.	 Miscellaneous 

(a) Taxes. It shall be a term of the grant of any Awards that the grantee and holder of the Award shall indemnify the
Company and each Affiliate in respect of, and shall be liable to pay to the Company or the Affiliate, or otherwise make provision satisfactory to the Administrator for payment of, any taxes (including social security or similar contributions
(including, if the Administrator determines at the date of grant of the Award and as permitted by law, employers’ social security or similar contributions)) which the Company or any Affiliate is required to withhold and/or account for to any
taxation authority in respect of Awards under the Plan and such payment or provision shall be made no later than the date of the event creating such tax liability. Without prejudice to the generality of the foregoing, the Company or its Affiliate
may, to the extent permitted by law: 
 (i) deduct an amount equal to any such tax liabilities from any payment of any kind
otherwise due to the grantee or holder of an Award; 
 (ii) withhold and sell such number of Shares to which the grantee
would otherwise become entitled on vesting or exercise of the Award as will provide the Company with an amount (after tax) equal to the amount of such tax and social security contributions for which it or any Affiliate is obliged to withhold or
account; 
 (iii) withhold Shares otherwise issued or issuable to the grantee on Vesting of the Award with a Fair Market
Value equal to the amount of such tax liabilities; and/or 

  
 - 13 - 

 (iv) if the Shares are then listed for trading on a public market, permit
the grantee to enter into a “same day sale” commitment with a broker whereby the grantee irrevocably elects to sell a portion of the Shares to be delivered under this Agreement to satisfy such tax liabilities and whereby the broker
irrevocably commits to forward the proceeds necessary to satisfy such tax liabilities directly to the Company. 
 In the event that payment
to the Company or its Affiliate of such tax liabilities is made in Shares, such shares shall be valued at Fair Market Value on the applicable date for such purposes and shall not exceed in amount the minimum statutory tax withholding obligation. For
the avoidance of doubt, the Administrator may specify in relation to any particular Award (to the extent permitted by law) that the social security contributions which the grantee is liable to pay shall include employer contributions as well as
employee contributions. 
 (b) Transferability. No Award granted under the Plan shall be transferred, assigned,
pledged, charged, or otherwise disposed of by a grantee to any person otherwise than by will or the laws of descent and distribution on death. Any purported transfer, assignment, pledge, charge or disposal shall cause the Award to lapse immediately.
An Award may be exercised during the lifetime of the grantee, only by the grantee or, during the period the grantee is under a legal disability, by the grantee’s guardian or legal representative. 

(c) Adjustments for Corporate Transactions and Other Events. 

 

	 	(i)	 Variation of Share Capital. In the event of any increase or variation of the share capital of the
Company by way of capitalization, rights issue, sub-division, consolidation, reduction of shares or otherwise, the Administrator shall make such adjustment to (A) the maximum number of shares of such
Shares as to which Awards may be granted under this Plan, as provided in Section 4 of the Plan, and the limits thereunder and (B) the description and/or number of shares covered by and the exercise price and other terms of outstanding
Awards, as it may determine in its absolute discretion to be appropriate provided that no adjustment shall result in the shares being issued at less than nominal value unless and to the extent that the Board is authorised to capitalize from the
reserves of the Company a sum equal to the amount by which the nominal value of the Shares to be allotted on exercise exceeds the price at which the shares may be subscribed, and to apply that sum in paying up such amount on the shares. The
Administrator may make adjustments, in its discretion, to address the treatment of fractional shares and fractional amounts that arise with respect to outstanding Awards as a result of the variation of share capital.  

(d) Substitution of Awards in Mergers and Acquisitions. Awards may be granted under the Plan from time to time in
substitution for awards held by employees, officers, consultants or directors of entities who become or are about to become employees, officers, consultants or directors of the Company or an Affiliate as the result of a merger or consolidation of
the employing entity with the Company or an Affiliate, or the acquisition by the Company or an Affiliate of the assets or shares of the employing entity. The terms and conditions of any substitute Awards so granted may vary from the terms and
conditions set forth herein to the extent that the Administrator deems appropriate at the time of grant to conform the substitute Awards to the provisions of the awards for which they are substituted. 

(e) Amendment to the Plan. 
  

	 	(i)	 General. Subject to this Section the Administrator may by resolution at any time and from time to time
make any alteration to the Plan which it thinks fit. 

  
 - 14 - 

	 	(ii)	 Shareholder approval. The following provisions of the Plan cannot be amended to the advantage of
grantees or potential grantees without the prior approval of the shareholders of the Company in general meeting except that minor amendments can be made without shareholder approval if they are to benefit the administration of the Plan or are
amendments to take account of a change in legislation or statutory regulations or are to obtain or maintain favourable tax, exchange control or regulatory treatment for grantees in the Plan or for the Company or any Affiliate: 

 

	 	(A)	 the basis for determining an eligible person’s entitlement (or otherwise) to be granted an Award and/or to
acquire Shares on Vesting of an Award; 

  

	 	(B)	 the persons to whom an Award may be granted; 

 

	 	(C)	 the limit on the aggregate number of Shares over which Awards may be granted under the Plan, including the
limit under Section 4(a)(iv); 

  

	 	(D)	 the individual participation limit in Section 4(b); 

 

	 	(E)	 the adjustment of Awards pursuant to section 10(c); and 

 

	 	(F)	 this section 10(e)(ii). 

 

	 	(iii)	 Alterations which adversely affect grantees. No alteration may be made which would materially increase
the liability of any grantee or which would materially decrease the value of any grantee’s subsisting rights attached to any outstanding Award without in each case that grantee’s prior written consent. 

(f) Termination of the Plan. The Board may terminate the Plan at any time. Except as otherwise determined by the Board,
termination of the Plan shall not affect the Administrator’s ability to exercise the powers granted to it hereunder with respect to Awards granted under the Plan prior to the date of such termination. 

(g) Non-Guarantee of Employment or Service. Nothing in the Plan or in any Grant
Agreement thereunder shall confer any right on an individual to continue in the service of the Company or shall interfere in any way with the right of the Company to terminate such service at any time with or without cause or notice and whether or
not such termination results in (i) the failure of any Award to vest; (ii) the forfeiture of any unvested or vested portion of any Award; and/or (iii) any other adverse effect on the individual’s interests under the Plan. 

This Plan shall not form part of the contract of employment of any individual who participates in it. The rights and
obligations of any individual under the terms of his office or employment with any Company participating in the Plan shall not be affected by his participation in the Plan or any right which he may have to participate in it. 

An individual who participates in the Plan shall waive any and all rights to compensation or damages in consequence of the
termination of his office or employment for any reason whatsoever (including unfair or wrongful dismissal) insofar as those rights arise or may arise from his ceasing to have rights under or to be entitled to exercise any Award or to be entitled to
under the Plan as a result of such termination. No such participation, rights or benefits shall be taken into account for the purposes of calculating the amount of benefits payable to any pension fund. Awards granted pursuant to the Plan shall not
constitute any representation or warranty that any benefit will accrue to any individual to whom such Award is granted. 

(h) Compliance with Securities Laws; Listing and Registration. If at any time the Administrator determines that the
delivery of Shares under the Plan, or exercise of Awards under the Plan, is or may be unlawful under the laws of any applicable jurisdiction, or federal, state or foreign securities laws, or may breach any Dealing Restriction, the right to exercise
an Award or receive Shares 

  
 - 15 - 

 
pursuant to an Award shall be suspended until the Administrator determines that such delivery is lawful or such Dealing Restriction ceases to apply, subject to and in compliance with
Section 409A. If an option may expire while a Dealing Restriction applies, the Administrator may, subject to applicable laws, provide for an automatic exercise of the option immediately before expiration. If at any time the Administrator
determines that the delivery of Shares under the Plan would or may violate the rules of the national exchange on which the shares are then listed for trade, the right to exercise an Award or receive Shares pursuant to an Award shall be suspended
until the Administrator determines that such delivery would not violate such rules. The Company shall have no obligation to effect any registration or qualification of the Shares under federal, state or foreign laws. 

The Company may require that a grantee, as a condition to exercise of an Award, and as a condition to the delivery of any share
certificate, make such written representations (including representations to the effect that such person will not dispose of the Shares so acquired in violation of federal, state or foreign securities laws) and furnish such information as may, in
the opinion of counsel for the Company, be appropriate to permit the Company to issue the Shares in compliance with applicable federal, state or foreign securities laws. The stock certificates for any Shares issued pursuant to this Plan may bear a
legend restricting transferability of the Shares unless such shares are registered or (if relevant) an exemption from registration is available under the Securities Act of 1933, as amended, and applicable state or foreign securities laws. 

Any transfer or issue of Shares pursuant to the Plan shall be subject to any necessary consent from any competent authority and
to the terms of such consent. 
 (i) No Trust or Fund Created. Neither the Plan nor any Award shall create or be
construed to create a trust or separate fund of any kind or a fiduciary relationship between the Company and a grantee or any other person. To the extent that any grantee or other person acquires a right to receive payments from the Company pursuant
to an Award, such right shall be no greater than the right of any unsecured general creditor of the Company. 
 (j)
Governing Law. The validity, construction and effect of the Plan, of Grant Agreements entered into pursuant to the Plan, and of any rules, regulations, determinations or decisions made by the Administrator relating to the Plan or such Grant
Agreements, and the rights of any and all persons having or claiming to have any interest therein or thereunder, shall be determined exclusively in accordance with the laws of England and the courts of England shall have exclusive jurisdiction to
settle any dispute which may arise out of or in connection with the Plan. Any proceedings suit or action arising out of the Plan shall be brought in such courts. 

(k) Section 409A. The Plan and all Awards granted hereunder are intended to comply with, or otherwise be exempt from,
Section 409A. The Plan and all Awards granted under the Plan shall be administered, interpreted, and construed in a manner consistent with Section 409A to the extent necessary to avoid the imposition of additional taxes under
Section 409A(a)(1)(B). Should any provision of the Plan, any Grant Agreement, or any other agreement or arrangement contemplated by the Plan be found not to be outside the scope of, comply with, or otherwise be exempt from, the provisions of
Section 409A, such provision shall be modified and given effect (retroactively if necessary), in the sole discretion of the Administrator, and without the consent of the holder of the Award, in such manner as the Administrator determines to be
necessary or appropriate to comply with, or to effectuate an exemption from, Section 409A. Notwithstanding anything in the Plan to the contrary, in no event shall the Administrator exercise its discretion to accelerate the payment or settlement
of an Award where such payment or settlement would otherwise constitute deferred compensation within the meaning of Section 409A unless, and solely to the extent that, such accelerated payment or settlement is permissible under Treasury
Regulation section 1.409A-3(j)(4) or any successor provision. 
 The following rules
shall apply to Awards subject to Section 409A: 
 (i) Cessation of service or “termination of employment,” or words of similar
import, for purposes of any payments under an Award that are payments of deferred compensation subject to Section 409A, shall mean the grantee’s “separation from service” as defined in Section 409A, to the extent required to
comply with Section 409A. 

  
 - 16 - 

 (ii) For purposes of Section 409A, the right to a series of installment
payments shall be treated as a right to a series of separate payments. 
 (iii) If payment of an Award arises on account of
the grantee’s separation from service while the grantee is a “specified employee” (as defined under Section 409A), then if necessary to comply with Section 409A, any payment that would be considered “deferred
compensation” (as defined under Treasury Regulation section 1.409A-1(b)(1), after giving effect to the exemptions in Treasury Regulation Sections 1.409A-1(b)(3)
through (b)(12)) that is scheduled to be paid within six (6) months after such separation from service shall accrue without interest and shall be paid within 15 days after the end of the six-month period
beginning on the date of such separation from service or, if earlier, within 15 days after the appointment of the personal representative or executor of the grantee’s estate following the grantee’s death. 

(l) Data Protection. By participating in the Plan, each grantee consents to the holding and processing of personal
information provided by the grantee to the Company or any Affiliate, trustee or third party service provider, for all purposes relating to the operation of the Plan. These include, but are not limited to: 

 

	 	(i)	 administering and maintaining grantee records; 

 

	 	(ii)	 providing information to the Company and its Affiliates, trustees of any employee benefit trust, registrars,
brokers or third party administrators of the Plan; 

  

	 	(iii)	 providing information to future purchasers or merger partners of the Company, the grantee’s employing
company, or the business in which the grantee works; and 

  

	 	(iv)	 transferring information about the grantee to a country or territory that may not provide the same statutory
protection for the information as the grantee’s home country. 

 (m) Duration of the Plan and
Termination. The Plan is effective from the Adoption Date. No Award shall be granted under the Plan after the close of business on the Termination Date. Subject to other applicable provisions of the Plan, all Awards made under the Plan prior
to such termination of the Plan shall remain in effect until such Awards have been satisfied or terminated in accordance with the Plan and the terms of such Awards. 

  
 - 17 - 

 PLAN APPROVAL 

Date Approved by the Board: 18 June 2015 
 Date Approved by
the Shareholders: 18 June 2015 

 APPENDIX A - PROVISIONS FOR CALIFORNIA RESIDENTS 

With respect to Awards granted to California residents prior to a public offering of shares of the Company that is effected pursuant to a
registration statement filed with, and declared effective by, the Securities and Exchange Commission under the Securities Act of 1933, as amended, and only to the extent required by applicable law, the following provisions shall apply
notwithstanding anything in the Plan or a Grant Agreement to the contrary: 
 1. With respect to any Award granted in the form of a share option pursuant to
Section 6(a) of the Plan: 
 (a) The exercise period shall be no more than 120 months from the date the option is granted. 

(b) The options shall be non-transferable other than by will, by the laws of descent and distribution,
or, if and to the extent permitted under the Grant Agreement, to a revocable trust or as permitted by Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701). 

(c) Unless employment is terminated for “cause” as defined by applicable law, the terms of the Plan or Grant Agreement, or a contract
of employment, the right to exercise the option in the event of termination of employment, to the extent that the Award recipient is entitled to exercise on the date employment terminates, will continue until the earlier of the option expiration
date, or: (1) At least 6 months from the date of termination if termination was caused by death or disability. (2) At least 30 days from the date of termination if termination was caused by other than death or disability. 

2. With respect to an Award, granted pursuant to Section 6(c) of the Plan, that provides the Award recipient the right to purchase shares, the Award
shall be non-transferable other than by will, by the laws of descent and distribution, or, if and to the extent permitted under the Grant Agreement, to a revocable trust or as permitted by Rule 701 of the
Securities Act of 1933, as amended (17 C.F.R. 230.701). 
 3. The Plan shall have a termination date of not more than 10 years from the date the
Plan is adopted by the Board or the date the Plan is approved by the security holders, whichever is earlier. 
 4. Security holders representing a majority
of the Company’s outstanding securities entitled to vote must approve the Plan by the later of (a) 12 months after the date the Plan is adopted or (b) 12 months after the granting of any Award to a resident of California. Any option exercised
or any securities purchased before security holder approval is obtained must be rescinded if security holder approval is not obtained within the period described in the preceding sentence. Such securities shall not be counted in determining whether
such approval is obtained. 
 5. The Company will provide financial statements to each Award recipient annually during the period such individual has Awards
outstanding, or as otherwise required under Section 260.140.46 of Title 10 of the California Code of Regulations. Notwithstanding the foregoing, the Company will not be required to provide such financial statements to Award recipients when the
Plan complies with all conditions of Rule 701 of the Securities Act of 1933, as amended (17 C.F.R. 230.701); provided that for purposes of determining such compliance, any registered domestic partner shall be considered a “family
member” as that term is defined in Rule 701. 
 6. The Plan is intended to comply with Section 25102(o) of the California Corporations Code. Any
provision of this Plan which is inconsistent with Section 25102(o), including without limitation any provision of this Plan that is more restrictive than would be permitted by Section 25102(o) as amended from time to time, shall, without
further act or amendment by the Board, be reformed to comply with the provisions of Section 25102(o). If at any time the Administrator determines that the delivery of Shares under the Plan is or may be unlawful under the laws of any applicable
jurisdiction, or federal or state securities laws, the right to exercise an Award or receive Shares pursuant to an Award shall be suspended until the Administrator determines that such delivery is lawful. The Company shall have no obligation to
effect any registration or qualification of the Shares under federal or state laws.EX-10.2

 Exhibit 10.2 

Grant No.: [__] 
 THIS
INCENTIVE STOCK OPTION DEED OF AGREEMENT is made on [Date of Grant] 

BETWEEN: 
 (1)
PURETECH HEALTH PLC (a company registered in England under number 9582467) whose registered office is at 5th Floor, 6 St Andrew Street, London EC4A 3AE, United Kingdom
(“Company”); 
 (2) PURETECH MANAGEMENT, INC. (a Delaware corporation)
whose registered address is at 6 Tide Street, Boston, Massachusetts (“Employer”); and 
 (3) [Recipient Name] (“Employee”
or “you”) 
 BACKGROUND 
  

	A.	 This agreement (“Agreement”) is made and the Options hereby granted are granted pursuant to
and subject to the terms of the PureTech Health plc Performance Share Plan (“Plan”). 

  

	B.	 The Employee is employed by the Employer at the date of this Agreement. The Employer is an Affiliate (as
defined in the Plan). 

 BY THIS DEED IT IS
AGREED AS FOLLOWS: 
 1. Terminology. Capitalized terms used in this
Agreement but which are not otherwise defined shall have the meanings ascribed thereto in the Glossary at the end of the Agreement or in the Plan. 

2. Grant and Exercise of Option. 

(a) By this Agreement, the Company hereby grants to the Employee [# of Shares] stock options (“Options”), each
Option permitting the purchase of one Share, subject to the terms of this Agreement and to the Plan, at an option exercise price (“Exercise Price”) of [_____] pence per Share. 

(b) Exercisability. The Options will vest and become exercisable in accordance with the Exercisability Schedule set forth in the
schedule to this Agreement (the “Exercisability Schedule”), so long as you are in the Service of the Company from the Grant Date through the applicable exercisability dates. None of the Options will become exercisable after your
Service with the Company ceases. 
 (c) Right to Exercise. You may exercise the Options, to the extent vested and exercisable, at any
time on or before the close of the principal market for the Shares on the Expiration Date or the earlier termination of the Options, unless otherwise provided under applicable law or the Plan. In particular, the Options shall not vest and you may
not exercise the Options at any time when any Dealing Restrictions prohibit such vesting or exercise. Notwithstanding the foregoing, if at any time the Administrator determines that the delivery of Shares under the Plan or this Agreement is or may
be unlawful under the laws of any applicable 

  
 - 1 - 

 
jurisdiction, or federal, state or foreign securities laws, the right to exercise the Options or receive Shares pursuant to the Options shall be suspended until the Administrator determines that
such delivery is lawful. If at any time the Administrator determines that the delivery of Shares under the Plan or this Agreement is or may violate the rules of the securities exchange on which the Shares are then listed for trade, the right to
exercise the Options or receive Shares pursuant to the Options shall be suspended until the Administrator determines that such exercise or delivery would not violate such rules. Section 3 below describes certain limitations on exercise of the
Options that apply in the event of your death, Total and Permanent Disability, or termination of Service. Exercise of the Options may also be limited in the event of certain corporate events as provided in the Plan. The Options may be exercised only
in multiples of whole Shares and may not be exercised at any one time as to fewer than one hundred Shares (or such lesser number of Shares as to which the Options are then exercisable). No fractional Shares will be issued under the Options. 

(d) Exercise Procedure. In order to exercise the Options, you must provide the following items to the Secretary of the Company or his
or her delegate before the expiration or termination of the Options: 
  

	 	(i)	 notice, in such manner and form as the Administrator may require from time to time, specifying the number of
Shares to be purchased under the Options; and 

  

	 	(ii)	 full payment of the Exercise Price for the Shares, each in accordance with Section 2(e) of this Agreement.

 An exercise will not be effective until the Secretary of the Company or his or her delegate receives all of the foregoing items, and
such exercise otherwise is permitted under and complies with all applicable federal, state and foreign securities laws. 
 (e) Method of
Payment. You may pay the Exercise Price by: 
  

	 	(i)	 delivery of cash, certified or cashier’s check, money order or other cash equivalent acceptable to the
Administrator in its discretion; 

  

	 	(ii)	 any other method approved by the Administrator; or 

 

	 	(iii)	 any combination of the foregoing. 

(f) Issuance of Shares upon Exercise. The Company shall issue to you the Shares underlying the Options you exercise as soon as
reasonably practicable after the valid exercise of the Options, subject to the Company’s receipt of requisite withholding taxes, if any. 

3. Termination of Service. 

(a) Termination of Unexercisable Options. If your Service with the Company ceases for any reason, the Options that are then unvested
and unexercisable will terminate immediately upon such cessation. 
 (b) Exercise Period Following Termination of Service. If your
Service with the Company ceases for any reason other than discharge for Cause, the Options that are then vested will terminate upon the earliest of: 

(i) the expiration of 90 days following such cessation, if your Service ceases on account of (1) your termination by the
Company other than a discharge for Cause or termination without Cause, or (2) your voluntary termination other than for Total and Permanent Disability or death; 

  
 - 2 - 

 (ii) the expiration of 6 months following such cessation, if your Service
ceases on account of your Total and Permanent Disability or death or your termination by the Company without Cause; or 

(iii) the Expiration Date. 
 In
the event of your death, the exercisable Options may be exercised by your executor, personal representative, or the person(s) to whom the Options are transferred by will or the laws of descent and distribution. 

(c) Misconduct. The Options will terminate in their entirety, regardless of whether the Options are then exercisable, immediately upon
your discharge from Service for Cause or Gross Misconduct, or upon your commission of any of the following acts during the exercise period following your termination of Service: (i) fraud on or misappropriation of any funds or property of the
Company, or (ii) your breach of any provision of any employment, non-disclosure, non-competition, non-solicitation,
assignment of inventions, or other similar agreement executed by you for the benefit of the Company, as determined by the Administrator, which determination will be conclusive. In addition, Section 7(f) of the Plan applies to the Options as
provided therein, and for the purposes of Section 7(f)(i) of the Plan, the period during which the repayment obligations apply shall be three years following the relevant vesting date of the Options. 

(d) Changes in Status. If you cease to be a “common law employee” of the Company but you continue to provide bona fide
services to the Company following such cessation in a different capacity, including without limitation as a director, consultant or independent contractor, then a termination of Service shall not be deemed to have occurred for purposes of this
Section 3 upon such change in capacity. Notwithstanding the foregoing, the Options shall not be treated as incentive stock options within the meaning of Code section 422 with respect to any exercise that occurs more than three months after such
cessation of the common law employee relationship (except as otherwise permitted under Code section 421 or 422). In the event that your Service is with a business, trade or entity that, after the Grant Date, ceases for any reason to be part or an
Affiliate of the Company, your Service will be deemed to have terminated for purposes of this Section 3 upon such cessation if your Service does not continue uninterrupted immediately thereafter with the Company or an Affiliate of the Company.

 4. Nontransferability of Options. These Options are nontransferable otherwise than by will or the laws of descent and distribution
and during your lifetime, the Options may be exercised only by you or, during the period you are under a legal disability, by your guardian or legal representative. Except as provided above, the Options may not be assigned, transferred, pledged,
hypothecated or disposed of in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process. Any purported, assignment, transfer, pledge, hypothecation or disposal shall cause the Options to
lapse immediately and as such they will immediately cease to be exercisable. 
 5. Qualified Nature of the Options. 

(a) General Status. The Options are intended to qualify as incentive stock options within the meaning of Code section 422
(“Incentive Stock Options”), to the fullest extent permitted by Code section 422, and this Agreement shall be so construed. The Company, however, does not warrant any particular tax consequences of the Options. Code
section 422 provides limitations, not set forth in this Agreement, respecting the treatment of the Options as Incentive Stock Options. You should consult with your personal tax advisors in this regard. 

  
 - 3 - 

 (b) Code Section 422(d) Limitation. Pursuant to Code
section 422(d), the aggregate fair market value (determined as of the Grant Date) of Shares with respect to which all Incentive Stock Options first become exercisable by you in any calendar year under the Plan or any other plan of the Company
(and its parent and subsidiary corporations, within the meaning of Code section 424(e) and (f), as may exist from time to time) may not exceed $100,000 or such other amount as may be permitted from time to time under Code section 422. To the
extent that such aggregate fair market value exceeds $100,000 or other applicable amount in any calendar year, such stock options will be treated as nonstatutory stock options with respect to the amount of aggregate fair market value thereof that
exceeds the Code section 422(d) limit. For this purpose, the Incentive Stock Options will be taken into account in the order in which they were granted. In such case, the Company may designate the Shares that are to be treated as stock acquired
pursuant to the exercise of Incentive Stock Options and the Shares that are to be treated as stock acquired pursuant to nonstatutory stock options by issuing separate certificates for such Shares and identifying the certificates as such in the stock
transfer records of the Company. 
 (c) Significant Stockholders. Notwithstanding anything in this Agreement to the contrary, if you
own, directly or indirectly through attribution, stock possessing more than 10% of the total combined voting power of all classes of stock of the Company or of any of its subsidiaries (within the meaning of Code section 424(f)) on the Grant Date,
then the Exercise Price is the greater of (a) the Exercise Price or (b) 110% of the Fair Market Value of the Shares on the Grant Date, and the Expiration Date is the last business day prior to the fifth anniversary of the Grant Date. 

(d) Disqualifying Dispositions. If you make a disposition (as that term is defined in Code section 424(c)) of any Shares acquired
pursuant to the Options within two years of the Grant Date or within one year after the Shares are transferred to you, you must notify the Company of such disposition in writing within 30 days of the disposition. The Administrator may, in its
discretion, take reasonable steps to ensure notification of such dispositions, including but not limited to requiring that Shares acquired under the Options be held in an account with a Company-designated broker-dealer until they are sold. 

6. Withholding of Taxes. 

(a) At the time the Options are exercised, in whole or in part, or at any time thereafter as requested by the Company, you hereby authorize
withholding from payroll or any other payment of any kind due to you and otherwise agree to make adequate provision for foreign, federal, state and local taxes required by law to be withheld, if any, which arise in connection with the Options
(including upon a disqualifying disposition within the meaning of Code section 421(b)). The Company may require you to make a cash payment to cover any withholding tax obligation as a condition of exercise of the Options or issuance of share
certificates representing Shares. 
 (b) The Administrator may, in its sole discretion, permit you to satisfy, in whole or in part, any
withholding tax obligation which may arise in connection with the Options either by electing to have the Company withhold and sell on your behalf from the Shares to be issued upon exercise that number of Shares having a Fair Market Value not in
excess of the amount necessary to satisfy the statutory minimum withholding amount due. 

  
 - 4 - 

 7. Adjustments. The Administrator may make various adjustments to your Options,
including adjustments to the number and type of securities subject to the Options and the Exercise Price, in accordance with the terms of the Plan. 

8. Non-Guarantee of Employment or Service Relationship. Nothing in the Plan or this Agreement
will alter your at-will or other employment status or other service relationship with the Company, nor be construed as a contract of employment or service relationship between you and the Company, or as a
contractual right for you to continue in the employ of, or in a service relationship with, the Company for any period of time, or as a limitation of the right of the Company to discharge you at any time with or without Cause or notice and whether or
not such discharge results in the failure of any of the Options to become exercisable or any other adverse effect on your interests under the Plan. 

You hereby waive any and all rights to compensation or damages in consequence of the termination of your Service for any reason whatsoever
insofar as those rights arise or may arise from you ceasing to have rights under or to be entitled to exercise the Options or to be entitled to participate in the Plan as a result of such termination. 

9. No Rights as a Stockholder. You shall not have any of the rights of a stockholder with respect to the Shares until such Shares have
been issued to you upon the due exercise of the Options. No adjustment will be made for dividends or distributions or other rights for which the record date is prior to the date such Shares are issued. 

10. The Company’s Rights. The existence of the Options shall not affect in any way the right or power of the Company or its
stockholders to make or authorize any or all adjustments, recapitalizations, reorganizations or other changes in the Company’s capital structure or its business, or any merger or consolidation of the Company, or any issue of bonds, debentures,
preferred or other stocks with preference ahead of or convertible into, or otherwise affecting the Shares or the rights thereof, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of the Company’s
assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise. 
 11. Entire Agreement.
This Agreement, together with the Plan, contain the entire agreement between you and the Company with respect to the Options. Any oral or written agreements, representations, warranties, written inducements, or other communications made prior to the
execution of this Agreement with respect to the Options shall be void and ineffective for all purposes. 
 12. Amendment. This
Agreement may be amended from time to time by the Administrator in its discretion; provided, however, that this Agreement may not be modified in a manner that would have a materially adverse effect on the Options or Shares as
determined in the discretion of the Administrator, except as provided in the Plan or in a written document signed by you and the Company. 

13. Conformity with Plan. This Agreement is intended to conform in all respects with, and is subject to all applicable provisions of,
the Plan. Any conflict between the terms of this Agreement and the Plan shall be resolved in accordance with the terms of the Plan. In the event of any ambiguity in this Agreement or any matters as to which this Agreement is silent, the Plan shall
govern. A copy of the Plan is provided to you with this Agreement. 

  
 - 5 - 

 14. Section 409A. This Agreement and the Options granted hereunder are intended to be
exempt from Section 409A of the Code. This Agreement and the Options shall be administered, interpreted and construed in a manner consistent with this intent. Nothing in the Plan or this Agreement shall be construed as including any feature for
the deferral of compensation other than the deferral of recognition of income until the exercise of the Options. Should any provision of the Plan or this Agreement be found not to comply with, or otherwise be exempt from, the provisions of
Section 409A of the Code, it may be modified and given effect, in the sole discretion of the Administrator and without requiring your consent, in such manner as the Administrator determines to be necessary or appropriate to comply with, or to
effectuate an exemption from, Section 409A of the Code. The foregoing, however, shall not be construed as a guarantee or warranty by the Company of any particular tax effect to you. 

15. Electronic Delivery of Documents. By your signing this Agreement, you (i) consent to the electronic delivery of this
Agreement, all information with respect to the Plan and the Options, and any reports of the Company provided generally to the Company’s stockholders; (ii) acknowledge that you may receive from the Company a paper copy of any documents
delivered electronically at no cost to you by contacting the Company by telephone or in writing; (iii) further acknowledge that you may revoke your consent to the electronic delivery of documents at any time by notifying the Company of such
revoked consent by telephone, postal service or electronic mail; and (iv) further acknowledge that you understand that you are not required to consent to electronic delivery of documents. 

16. No Future Entitlement. By execution of this Agreement, you acknowledge and agree that: (i) the grant of these Options is a one-time benefit which does not create any contractual or other right to receive future grants of stock options, or compensation in lieu of stock options, even if stock options have been granted repeatedly in the
past; (ii) all determinations with respect to any such future grants, including, but not limited to, the times when stock options shall be granted or shall become exercisable, the maximum number of Shares subject to each stock option, and the
purchase price, will be at the sole discretion of the Administrator; (iii) the value of these Options is an extraordinary item of compensation which is outside the scope of your employment contract, if any; (iv) the value of these Options
is not part of normal or expected compensation or salary for any purpose, including, but not limited to, calculating any termination, severance, resignation, redundancy, end of service payments or similar payments, or bonuses, long-service awards,
pension or retirement benefits; (v) the vesting of these Options ceases upon termination of employment with the Company or transfer of employment from the Company, or other cessation of eligibility for any reason, except as may otherwise be
explicitly provided in this Agreement; (vi) if the underlying Shares does not increase in value, these Options will have no value, nor does the Company guarantee any future value; and (vii) no claim or entitlement to compensation or
damages arises if these Options do not increase in value and you irrevocably release the Company from any such claim that does arise. 
 17.
Personal Data. For the purpose of implementing, administering and managing these Options, you, by execution of this Agreement, consent to the collection, receipt, use, retention and transfer, in electronic or other form, of your personal data
by the Company, any Affiliate, trustee or third party service provider or any potential future purchaser or merger partner of the Company or an Affiliate. You understand that personal data (including but not limited to, name, home address, telephone
number, employee number, employment status, social security number, tax identification number, date of birth, nationality, job and payroll location, data for tax withholding purposes and shares awarded, cancelled, exercised, vested and unvested) may
be transferred to third parties assisting in the implementation, administration and management of these Options and the Plan and you expressly authorize such transfer as well as the retention, use, and the subsequent transfer of the data by the
recipient(s). You understand that these recipients may be 

  
 - 6 - 

 
located in your country or elsewhere, and that the recipient’s country may have different data privacy laws and protections than your country. You understand that data will be held only as
long as is necessary to implement, administer and manage these Options. You understand that you may, at any time, request a list with the names and addresses of any potential recipients of the personal data, view data, request additional information
about the storage and processing of data, require any necessary amendments to data or refuse or withdraw the consents herein, in any case without cost, by contacting in writing the Company’s Secretary. You understand, however, that refusing or
withdrawing your consent may affect your ability to accept a stock option. 
 18. Governing Law. The validity, construction and
effect of this Agreement, and of any determinations or decisions made by the Administrator relating to this Agreement, and the rights of any and all persons having or claiming to have any interest under this Agreement, shall be determined
exclusively in accordance with the laws of England and the courts of England shall have exclusive jurisdiction to settle any dispute which may arise out of or in connection with this Agreement or the Plan. Any proceedings suit or action arising out
of this Agreement or the Plan shall be brought in such courts. 
 19. Resolution of Disputes. Any dispute or disagreement which shall
arise under, or as a result of, or pursuant to or relating to, this Agreement shall be determined by the Administrator in good faith in its absolute and uncontrolled discretion, and any such determination or any other determination by the
Administrator under or pursuant to this Agreement and any interpretation by the Administrator of the terms of this Agreement, will be final, binding and conclusive on all persons affected thereby. You agree that before you may bring any legal action
arising under, as a result of, pursuant to or relating to, this Agreement you will first exhaust your administrative remedies before the Administrator. You further agree that in the event that the Administrator does not resolve any dispute or
disagreement arising under, as a result of, pursuant to or relating to, this Agreement to your satisfaction, no legal action may be commenced or maintained relating to this Agreement more than twenty-four (24) months after the
Administrator’s decision. 
 20. Counterparts. This deed may be executed in any number of counterparts each of which, when
executed by one or more of the parties hereto, shall constitute and original but all of which shall constitute one and the same instrument 

21. Headings. The headings in this Agreement are for reference purposes only and shall not affect the meaning or interpretation of this
Agreement. 
 {Glossary begins on next page} 

  
 - 7 - 

 GLOSSARY 

(a) “Company” includes PureTech Health plc and its Affiliates, except where the context otherwise requires. 

(b) “Expiration Date” means the last business day prior to the 10th anniversary of the Grant Date. 

(c) “Grant Date” means the date of this Agreement. 

(d) “Service” means your employment or other service relationship with the Company and its Affiliates. Your Service
will be considered to have ceased with the Company and its Affiliates if, immediately after a sale, merger or other corporate transaction, the trade, business or entity with which you are employed or otherwise have a service relationship is not the
Company or its successor or an Affiliate of the Company or its successor. 
 (e) “Total and Permanent Disability”
means the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period
of not less than twelve months. The Administrator may require such proof of Total and Permanent Disability as the Administrator in its sole discretion deems appropriate and the Administrator’s good faith determination as to whether you are
totally and permanently disabled will be final and binding on all parties concerned. 
 (f) “You”;
“Your”. “You” or “your” means the Employee. Whenever the Agreement refers to “you” under circumstances where the provision should logically be construed, as determined by the Administrator, to
apply to your estate, personal representative, or beneficiary to whom the Options may be transferred by will or by the laws of descent and distribution, the word “you” shall be deemed to include such person. 

  
 - 8 - 

 SCHEDULE 

EXERCISABILITY SCHEDULE 

Subject to the terms and conditions described in the Agreement and the Plan, the Options vest and become exercisable as follows: 

 

	 	(a)	 [25]% of the Options (i.e. to acquire a total of [____] Shares, the “Initial Shares”) vest and
become exercisable on [______] (the “Initial Vesting Date”), and 

  

	 	(b)	 [75]% of the Options (i.e. to acquire a total of [____] Shares) vest and become exercisable in 6 equal
semi-annual installments (the Shares vesting in each such Semi-Annual Period, the “Semi-Annual Shares”) with the first such installment vesting on the 6-month anniversary of the Initial
Vesting Date and an additional installment each 6-month anniversary thereafter through the third anniversary of the Initial Vesting Date (each such semi-annual vesting period, a “Semi-Annual
Period”). 

 The extent to which the Options are exercisable as of a particular date is rounded down to the nearest whole Share.
However, exercisability is rounded up to 100% on the third anniversary of the Initial Vesting Date. 

  
 - 9 - 

									
	 Executed as a deed, but not delivered until the

first date specified on page 1, by PURETECH
 HEALTH
PLC by a director in the presence
 of a witness:
	  	 )
 )

)
 )
	  	Signature	  	 
					
		  		  		  	Name (block capitals)	  	Stephen Muniz
		  		  		  		  	Director
	Witness signature	  	 	  		  		  	
					
	Witness name	  	 	  		  		  	
	(block capitals)	  		  		  		  	
					
	Witness address	  	6 Tide Street	  		  		  	
					
		  	Suite 400	  		  		  	
					
		  	Boston, MA 02210	  		  		  	
				
	 Executed as a deed, but not delivered until the

first date specified on page 1, by PURETECH
 MANAGEMENT,
INC. by an officer in the
 presence of a witness:
	  	 )
 )

)
 )
	  	Signature	  	 
					
		  		  		  	Name (block capitals)	  	Stephen Muniz
		  		  		  		  	Chief Operating Officer
	Witness signature	  	 	  		  		  	
					
	Witness name	  	 	  		  		  	
	(block capitals)	  		  		  		  	
					
	Witness address	  	6 Tide Street	  		  		  	
					
		  	Suite 400	  		  		  	
					
		  	Boston, MA 02210	  		  		  	

  
 [PureTech Health –
Signature Page to Incentive Stock Option Deed of Agreement] 

									
	 Signed as a deed, but not delivered until the first

date specified on page 1, by [Recipient Name]
 in the presence
of:
	  	 )
 )

)
 )
	  	Signature	  	                                      
  
					
	Witness signature	  	 	  		  		  	
					
	Witness name	  	 	  		  		  	
				
	                                    
      (block capitals)	  		  		  	
					
	Witness address	  	 	  		  		  	
					
		  	 	  		  		  	
					
		  	 	  		  		  	

  
 [PureTech Health –
Signature Page to Incentive Stock Option Deed of Agreement]

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