Document:

EXHIBIT 10.13

 Exhibit 10.13 
  
                     September 15, 2005 
  
 Ladenburg Thalmann & Co. Inc. 
 590 Madison Avenue 
 34th Floor 
 New York, New York 10022 
  
 Re: Endeavor Acquisition Corp. 
  
 Gentlemen: 
  
 This letter will confirm the agreement of the undersigned to purchase warrants (“Warrants”) of Endeavor Acquisition Corp. (“Company”) included in the units (“Units”) being sold in the
Company’s initial public offering (“IPO”) upon the terms and conditions set forth herein. Each Unit is comprised of one share of common stock of the Company (“Common Stock”) and one Warrant. The shares of Common Stock and
Warrants will not be separately tradable until 90 days after the effective date of the Company’s IPO, unless Ladenburg Thalmann & Co. Inc. (“Ladenburg”) informs the Company of its decision to allow earlier separate trading.

  
 The undersigned agrees that this letter agreement (which may
be evidenced by original or facsimile counterpart signatures hereto) constitutes an irrevocable order for Ladenburg or an independent broker/dealer designated by Ladenburg (in either case, the “Broker”) to purchase for the
undersigned’s account within the 90-day period commencing on the date separate trading of the Warrants commences (“Separation Date”) up to 5,000,000 Warrants at market prices not to exceed $1.00 per Warrant (“Maximum Warrant
Purchase”). The Broker agrees to fill such order in such amounts and at such times as it may determine, in its sole discretion, during the 90-day period commencing on the Separation Date (such period is hereinafter referred to as the
“Purchase Period”). Ladenburg further agrees that it will not charge the undersigned any fees and/or commissions with respect to such purchase obligation. 
  
 This letter is similar to the letter (the “Other Letter”) with
                     (the “Other Founder”) obligating the Other Founder to similarly purchase Warrants. The Broker agrees that at
any time it purchases Warrants under this letter or the Other Letter, it will use reasonable commercial efforts to purchase Warrants for the account of the undersigned and the Other Founder, pro rata, on the basis of the Maximum Warrant Purchase set
forth herein and in the Other Letter. 
  
 The undersigned may
notify the Broker that all or part of the Maximum Warrant Purchase will be made by an affiliate of the undersigned (or another person or entity introduced to the Broker by the undersigned (a “Designee”)) who (or which) has an account with
the Broker and, in such event, the Broker will make such purchase on behalf of said affiliate or Designee; provided, however, that the undersigned hereby agrees to make payment of the purchase price of such purchase in the event that the affiliate
or Designee fails to make such payment. 
  
 The Broker will
promptly notify the undersigned of any purchase of Warrants hereunder and under the Other Letter so that the undersigned can comply with applicable reporting requirements on a timely basis. 
  
 The undersigned agrees that he shall not sell or transfer the Warrants until
after the consummation of a merger, capital stock exchange, asset acquisition or other similar business combination with an operating business and acknowledges that, at the option of Ladenburg, the certificates for such Warrants shall contain a
legend indicating such restriction on transferability. 
  

	
	 Very truly yours,

	
	 

			
	 ACKNOWLEDGED AND AGREED:

	
	 Ladenburg Thalmann & Co. Inc.

		
	 By:
	 	 
	
	 [Independent Broker]

		
	 By:Letter Agreement, dated September 14, 2005

 EXHIBIT 10.1 
  
 September 14, 2005 
  
 Mr. Fred Lash 
 Hooper Holmes, Inc. 
 170 Mt. Airy Road 
 Basking Ridge, NJ 07920 
  
 Dear Fred: 
  
 This letter will confirm our recent conversation and supersedes the letter from Quentin J. Kennedy, Chairman of the Audit
Committee, dated August 17, 2005 and countersigned by you. 
  
 Hooper Holmes, Inc. (“the Company”) is desirous of you making your services available, at reasonable times, from September 15, 2005 through the end of the year. In consideration of you making yourself available, the Company will
pay you the sum of $60,000, less lawful withholdings, within ten (10) days following September 15, 2005. 
  
 If you are in agreement with the foregoing, please sign and return the enclosed copy of this letter. 
  

	
	Sincerely,
	
	 /s/ Benjamin A. Currier

	Benjamin A. Currier
	Interim Chief Executive Officer & Chairman of the Board

  

	
	Agreed:
	
	 /s/ Fred Lash

	Fred LashThird Amendment to Lease between The Irvine Company and Nuvelo, Inc

 Exhibit 10.58 
  
 THIRD AMENDMENT TO LEASE 
  
 I. PARTIES AND DATE. 
  
 This Third Amendment to Lease (the “Amendment”) dated September 15, 2005, is by and between THE IRVINE COMPANY (“Landlord”), and
NUVELO, INC., a Delaware corporation (“Tenant”). 
  
 II. RECITALS.

  
 On April 30, 2001, Landlord and Tenant entered into a
lease for space in a building located at 985 Almanor, Sunnyvale, California (“Premises”), which lease was amended by a First Amendment to Lease dated August 1, 2002 (the “First Amendment”) and by a Second Amendment to Lease dated
October 21, 2003 (the “Second Amendment”) (collectedly, the “Lease”). 
  
 Landlord and Tenant each desire to modify the Lease to make such modifications as are set forth in “III. MODIFICATIONS” next below. 
  
 III. MODIFICATIONS. 
  
 A. Basic Lease Provisions. The Basic Lease Provisions are hereby amended as follows: 
  
 1. Item 7 is hereby deleted in its entirety and substituted therefor shall be the following: 
  
 “7. Guarantor(s): None” 
  
 2. Item 12 is hereby amended by deleting Landlord’s address for
payments and notices and substituted therefor shall be the following: 
  
 “LANDLORD 
  
 THE IRVINE COMPANY 
 550 Newport Center Drive 
 Newport Beach, CA 92660 
 Attn: Senior Vice President, Operations 
 Irvine Office Properties 
  
 with a copy of notices to: 
  
 THE IRVINE COMPANY 
 550 Newport Center Drive 
 Newport Beach, CA 92660 
 Attn: Vice President, Operations 
 Irvine Office Properties, Technology Portfolio” 

 B. Early Reinstatement of Rent. Section III.F of the Second Amendment is hereby deleted in its
entirety and substituted therefore shall be the following: 
  
 “In the event that Tenant shall successfully raise Seventy-Five Million Dollars ($75,000,000.00) in cash as a result of a single public or private offering, no later than five (5) days thereafter, Tenant shall pay to Landlord ten
percent (10%) of such cash in excess of Seventy-Five Million Dollars ($75,000,000.00) up to the full amount of the sum of Tenant’s obligations to pay (i) the “Additional Deferred Base Rent Payment” (as defined in the Second
Amendment), and (ii) the unpaid installments of “Additional Rent” (as defined in the First amendment), without benefit of a “present value” computation in favor of Tenant. Said payment to Landlord shall be applied
against Tenant’s Additional Deferred Base Rent Payment and against installments of Additional Rent in the following order of priority: 
  

	 	(i)	Up to the full amount of the Additional Deferred Base Rent Payment; and then 

  

	 	(ii)	Up to the full amount of each of the unpaid $148,150.00 installments of Additional Rent, to be applied to such installments in the reverse chronological order of their dates due
(that is, applicable first against the installment due May 1, 2009, then against the installment due April 1, 2009, and so forth). Any installment of Additional Rent to which said payment to Landlord is not so applied, shall remain due and payable
in accordance with the schedule set forth therefor in the First Amendment. 

  
 Tenant agrees that it shall give prompt written notice to Landlord of the raising of such cash from such offering.” 
  
 C. Letter of Credit. Not later than the Tenant’s execution of this Amendment, Tenant shall increase the principal amount of the Letter of
Credit referred to in Section 4.4 of the Lease to Six Million Dollars ($6,000,000.00) pursuant to an amendment to that Letter of Credit acceptable to Landlord. Notwithstanding anything to the contrary in the Lease or in the First or Second
Amendments, it is understood and agreed that the foregoing Letter of Credit shall stay in effect through the entire scheduled ten (10) year Lease Term, and that Landlord shall not be required to authorize any earlier termination or reduction of the
Letter of Credit. The reference in the first (1st) sentence of Section 4.4 of the Lease to “Four Million
Dollars ($4,000,000.00)” is hereby revised to “Six Million Dollars ($6,000,000.00).” 
  
 D. Security. Section III.F of the First Amendment to Lease is hereby deleted in its entirety and shall have no further force or effect. 

 E. Release of Guarantee. Landlord hereby releases Dr. George B. Rathmann, the
“Guarantor” under that certain Guarantee of Lease dated April 30, 2001, from further obligation under said Guarantee as to obligations accruing under the Lease from and after the date of this Amendment. 
  
 IV. GENERAL. 
  
 A. Effect of Amendments. The Lease shall remain in full force and effect except to the extent that it is modified by
this Amendment. 
  
 B. Entire Agreement. This Amendment
embodies the entire understanding between Landlord and Tenant with respect to the modifications set forth in “III. MODIFICATIONS” above and can be changed only by a writing signed by Landlord and Tenant. 
  
 C. Counterparts. If this Amendment is executed in counterparts, each
is hereby declared to be an original; all, however, shall constitute but one and the same amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation.

  
 D. Defined Terms. All words commencing with initial
capital letters in this Amendment and defined in the Lease shall have the same meaning in this Amendment as in the Lease, unless they are otherwise defined in this Amendment. 
  
 E. Corporate and Partnership Authority. If Tenant is a corporation or partnership, or is comprised of either or both
of them, each individual executing this Amendment for the corporation or partnership represents that he or she is duly authorized to execute and deliver this Amendment on behalf of the corporation or partnership and that this Amendment is binding
upon the corporation or partnership in accordance with its terms. 
  
 F. Attorneys’ Fees. The provisions of the Lease respecting payment of attorneys’ fees shall also apply to this Amendment. 

 V. EXECUTION. 
  
 Landlord and Tenant executed this Amendment on the date as set forth in “I. PARTIES AND DATE.” above. 
  

							
	LANDLORD:	 	TENANT:
		
	THE IRVINE COMPANY	 	NUVELO, INC.,
	 	 	 	 	a Nevada corporation
				
	By	 	 /s/ Steven M. Case

	 	By	 	 /s/ Ted W. Love

	 	 	Steven M. Case, Senior Vice President	 	 	 	Ted W. Love
	 	 	Leasing, Office Properties	 	 	 	President and CEO
				
	By	 	 /s/ Christopher J. Popma

	 	By	 	 /s/ Lee Bendekgey

	 	 	Christopher J. Popma, Vice President	 	 	 	Lee Bendekgey
	 	 	Operations, Office Properties	 	 	 	CFO and General Counsel

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