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                                                                   EXHIBIT 10.27

                           EPIX PHARMACEUTICALS, INC.
                DESCRIPTION OF DIRECTOR COMPENSATION ARRANGEMENTS

         The Company pays each non-employee director who serves as a chairman of
a committee of the Board an annual fee of $25,000 for service as a director
of the Company and as a committee chairman. The Company pays each
non-employee director who does not also serve as a chairman of a committee of
the Board an annual fee of $15,000 for service as a director of the Company.
In addition, non-employee directors are eligible to participate in the
Company's Amended and Restated 1996 Director Stock Option Plan (the "Director
Plan"). There are currently 300,000 shares of common stock reserved for
issuance under the Director Plan. Upon the appointment, election or
reelection of a non-employee director, such director is automatically granted
an option to purchase 25,000 shares of common stock. Such options become
exercisable in equal installments over a three year period on each
anniversary of the grant, provided that the optionee is still a director of
the Company at the opening of business on such date. In addition, each
non-employee director is automatically granted an option to purchase 5,000
shares of common stock annually during the years in which such director is
not up for reelection to the Board. Such options become exercisable in full
on the first anniversary date of the grant, provided that the optionee is
still a director of the Company at the opening of business on such date. Each
option has a term of ten years. The exercise price for each option is equal
to the last sale price for the common stock on the business day immediately
preceding the date of grant, as reported on the NASDAQ National Market. The
exercise price may be paid in cash, shares of common stock or a combination
of both. Directors who are also employees of the Company do not receive any
additional compensation for their service on the Board or any committee
thereof.<Page>

                                                                  EXHIBIT 10. 28

                           EPIX PHARMACEUTICALS, INC.
               NAMED EXECUTIVE OFFICERS COMPENSATION ARRANGEMENTS

         The following are our named executive officers. Their salaries for 2005
have been set as follows:

<Table>
<Caption>
                                                                                        2005
NAMED EXECUTIVE OFFICER                    POSITION                                    SALARY
-------------------------------- --------------------------------------            -----------------
<S>                              <C>                                               <C>
Michael D. Webb                  Chief Executive Officer                               $ 350,301

Andrew C.G. Uprichard, M.D.      President & Chief Operating Officer                   $ 311,160

Peyton J. Marshall, Ph.D.        Senior Vice President and                             $ 240,750
                                 Chief Financial Officer

Alan P. Carpenter, Ph.D., J.D.   Vice President, Legal and                             $ 257,237
                                 Government Affairs

Thomas J. McMurry, Ph.D.         Vice President, Research                              $ 224,328

Gregg Mayer                      Vice President, Strategic Marketing                   $ 210,431
                                 and Corporate Communications

</Table><Page>

                                                                 Exhibit 10.29

                           EPIX PHARMACEUTICALS, INC.

                        FORM OF INDEMNIFICATION AGREEMENT

         This Agreement dated _______________ is between EPIX Pharmaceuticals,
Inc. (the "Company"), a Delaware corporation, and ________________ (the
"Indemnitee"), who is an [officer] [a director] [an officer and director] of the
Company. Its purpose is to provide the maximum protection for the Indemnitee
against personal liability arising out of his or her service to the Company so
as to encourage the continuation of such service and the effective exercise of
his or her business judgment in connection therewith.

         The parties hereto agree as follows:

         1. DEFINITIONS. For purposes of this Agreement, the following terms
shall have the meanings hereafter assigned to them:

         (a) CHANGE IN CONTROL: a change in control of the Company of a nature
that would be required to be reported in response to Item 6(e) of Schedule 14A
of Regulation 14A promulgated under the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), whether or not the Company is in fact required to
comply therewith; provided, that, without limitation, such a change in control
shall be deemed to have occurred if:

                  (i) any "person" (as such term is used in Sections 13(d) and
         14(d) of the Exchange Act), other than the Company, any trustee or
         other fiduciary holding securities under an employee benefit plan of
         the Company or a corporation owned, directly or indirectly, by the
         stockholders of the Company in substantially the same proportions as
         their ownership of stock of the Company is or becomes the "beneficial
         owner" (as defined in Rule 13d-3 under the Exchange Act), directly or
         indirectly, of securities of the Company representing 30% or more of
         the combined voting power of the Company's then outstanding securities;
         or

                  (ii) during any period of twenty-four (24) consecutive months
         (not including any period prior to the date of this Agreement),
         individuals who at the beginning of such period constitute the
         Company's Board of Directors (the "Board") and any new director (other
         than a director designated by a person who has entered into an
         agreement with the Company to effect a transaction described in
         paragraphs (i), (ii) or (iii) of this Section 1(a)) whose election by
         the Board or nomination for election by the stockholders of the Company
         was approved by a vote of at least two-thirds (2/3) of the directors
         then still in office who either were directors at the beginning of such
         period or whose election or nomination for election was previously so
         approved, cease for any reason to constitute a majority thereof; or

                  (iii) the stockholders of the Company approve a merger or
         consolidation of the Company with any other corporation, other than (A)
         a merger or consolidation which would result in the voting securities
         of the Company outstanding immediately prior thereto continuing to
         represent (either by remaining outstanding or by being converted

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         into voting securities of the surviving entity) at least 50% of the
         combined voting securities of the Company or such surviving entity
         outstanding immediately after such merger or consolidation or (B) a
         merger or consolidation effected to implement a recapitalization of the
         Company (or similar transaction) in which no "person" (as hereinabove
         defined) acquires 30% or more of the combined voting power of the
         Company's then outstanding securities; or

                  (iv) the stockholders of the Company approve a plan of
         complete liquidation of the Company or an agreement for the sale or
         disposition by the Company of all or substantially all of the Company's
         assets.

         (b) CLAIM: any threatened, pending or completed action, suit or
proceeding, or any inquiry or investigation, whether instituted by the Company
or any other party that the Indemnitee in good faith believes might lead to the
institution of any such action, suit or proceeding, whether civil, criminal,
administrative, investigative or other.

         (c) EXPENSES: include attorneys' fees and all other costs, expenses and
obligations paid or incurred in connection with investigating, defending, being
a witness in or participating in (including on appeal), or preparing to defend,
be a witness in or participate in, any Claim relating to any Indemnifiable
Event.

         (d) INDEMNIFIABLE EVENT: any event or occurrence related to the fact
that the Indemnitee is or was a director, officer, employee, agent or fiduciary
of the Company, or is or was serving at the request of the Company as a
director, officer, employee, trustee, agent or fiduciary of another corporation,
partnership, joint venture, employee benefit plan, trust or other enterprise, or
by reason of anything done or not done by the Indemnitee in any such capacity.

         (e) POTENTIAL CHANGE IN CONTROL: shall be deemed to have occurred if:

                  (i) the Company enters into an agreement, the consummation of
         which would result in the occurrence of a Change in Control;

                  (ii) any person (as hereinabove defined), including the
         Company, publicly announces an intention to take or consider taking
         actions which if consummated would constitute a Change in Control;

                  (iii) any person (as hereinabove defined), other than the
         Company, any trustee or other fiduciary holding securities under an
         employee benefit plan of the Company or a corporation owned, directly
         or indirectly, by the stockholders of the Company in substantially the
         same proportions as their ownership of stock of the Company (A) is or
         becomes the beneficial owner, (B) discloses directly or indirectly to
         the Company or publicly a plan or intention to become the beneficial
         owner, or (C) makes a filing under the Hart-Scott-Rodino Antitrust
         Improvements Act of 1976, as amended, with respect to securities to
         become the beneficial owner, directly or indirectly, of securities
         representing 9.9% or more of the combined voting power of the
         outstanding voting securities of the Company; or

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                  (iv) the Board adopts a resolution to the effect that, for
         purposes of this Agreement, a potential change in control of the
         Company has occurred.

         (f) REVIEWING PARTY: The person or body appointed by the Board pursuant
to Section 2(b), which shall not be or include a person who is a party to the
particular Claim for which the Indemnitee is seeking indemnification.

         2. BASIC INDEMNIFICATION ARRANGEMENT. (a) In the event that the
Indemnitee was, is or becomes a party to or witness or other participant in, or
is threatened to be made a party to or witness or other participant in, a Claim
by reason of (or arising in part out of) an Indemnifiable Event, the Company
shall indemnify the Indemnitee to the fullest extent permitted by law as soon as
practicable, but in any event no later than thirty days after written demand is
presented to the Company, against all Expenses, judgments, fines, penalties and
amounts paid in settlement (including all interest, assessments and other
charges paid or payable in connection with or in respect of such Expenses,
judgments, fines, penalties or amounts paid in settlement) of such Claim. If so
requested by the Indemnitee, the Company shall advance (within ten business days
of such request) all Expenses to the Indemnitee (an "Expense Advance").
Notwithstanding anything in this Agreement to the contrary, prior to a Change in
Control, the Indemnitee shall not be entitled to indemnification pursuant to
this Agreement in connection with any Claim initiated by the Indemnitee against
the Company or any director or officer of the Company (otherwise than to enforce
his or her rights under this Agreement) unless the Company has consented in
writing to the initiation of such Claim.

         (b) In the event of any demand by the Indemnitee for indemnification
hereunder or under the Company's Restated Certificate of Incorporation or
By-laws, the Board shall designate a Reviewing Party, who shall, if there has
been a Change of Control of the Company, be the special independent counsel
referred to in Section 3 hereof. The obligations of the Company under Section
2(a) shall be subject to the condition that the Reviewing Party shall not have
determined (in a written opinion, in any case in which the special independent
counsel referred to in Section 3 hereof is involved) that the Indemnitee is not
permitted to be indemnified under applicable law, and the obligation of the
Company to make an Expense Advance pursuant to Section 2(a) shall be subject to
the condition that, if, when and to the extent that the Reviewing Party
determines that the Indemnitee is not permitted to be so indemnified under
applicable law, the Company shall be entitled to be reimbursed by the Indemnitee
(who hereby agrees to reimburse the Company) for all such amounts theretofore
paid. If the Indemnitee has commenced legal proceedings in a court of competent
jurisdiction to secure a determination that the Indemnitee may be indemnified
under applicable law, any determination made by the Reviewing Party that the
Indemnitee is not permitted to be indemnified under applicable law shall not be
binding, and the Indemnitee shall not be required to reimburse the Company for
any Expense Advance until a final judicial determination is made with respect
thereto (as to which all rights of appeal therefrom have been exhausted or
lapsed). If there has been no determination by the Reviewing Party or if the
Reviewing Party determines that the Indemnitee is not permitted to be
indemnified in whole or in part under applicable law, the Indemnitee shall have
the right to commence litigation in any court in the state of Delaware having
subject matter jurisdiction thereof and in which venue is proper seeking an
initial determination by the court or challenging any such determination by the
Reviewing Party or any aspect thereof, and the Company hereby

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consents to service of process and to appear in any such proceeding. Any
determination by the Reviewing Party otherwise shall be conclusive and binding
on the Company and the Indemnitee.

         3. CHANGE IN CONTROL. The Company agrees that if there is a Change in
Control of the Company, then with respect to all matters thereafter arising
concerning the rights of the Indemnitee to indemnity payments and Expense
Advances under this Agreement or any other agreement or under the Company's
Restated Certificate of Incorporation or By-laws now or hereafter in effect
relating to Claims for Indemnifiable Events, the Company shall seek legal advice
only from special independent counsel selected by the Indemnitee and approved by
the Company (which approval shall not be unreasonably withheld) who has not
otherwise performed services for the Company within the last ten years (other
than in connection with such matters) or for the Indemnitee. Such counsel, among
other things, shall render its written opinion to the Company and the Indemnitee
as to whether and to what extent the Indemnitee is permitted to be indemnified
under applicable law. The Company agrees to pay the reasonable fees of the
special independent counsel and to indemnify such counsel against any and all
expenses (including attorneys' fees), claims, liabilities and damages relating
to this Agreement or its engagement pursuant hereto.

         4. ESTABLISHMENT OF TRUST. In the event of a Potential Change in
Control, the Company may create a trust for the benefit of the Indemnitee
(either alone or together with one or more other indemnitees) and from time to
time fund such trust in such amounts as the Board may determine to satisfy
Expenses reasonably anticipated to be incurred in connection with investigating,
preparing for and defending any Claim relating to an Indemnifiable Event, and
all judgments, fines, penalties and settlement amounts of all Claims relating to
an Indemnifiable Event from time to time paid or claimed, reasonably anticipated
or proposed to be paid. The terms of any trust established pursuant hereto shall
provide that upon a Change in Control (i) the trust shall not be revoked or the
principal thereof invaded, without the written consent of the Indemnitee, (ii)
the trustee shall advance, within ten business days of a request by the
Indemnitee, all Expenses to the Indemnitee (and the Indemnitee hereby agrees to
reimburse the trust under the circumstances under which the Indemnitee would be
required to reimburse the Company under Section 2(b) of this Agreement), (iii)
the trustee shall promptly pay to the Indemnitee all amounts for which the
Indemnitee shall be entitled to indemnification pursuant to this Agreement or
otherwise, and (iv) all unexpended funds in such trust shall revert to the
Company upon a final determination by the Reviewing Party or a court of
competent jurisdiction, as the case may be, that the Indemnitee has been fully
indemnified under the terms of this Agreement. The trustee shall be a person or
entity satisfactory to the Indemnitee. Nothing in this Section 4 shall relieve
the Company of any of its obligations under this Agreement.

         5. INDEMNIFICATION FOR ADDITIONAL EXPENSES: The Company shall indemnify
the Indemnitee against all expenses (including attorneys' fees) and, if
requested by the Indemnitee, shall (within ten business days of such request)
advance such expenses to the Indemnitee, which are incurred by the Indemnitee in
connection with any claim asserted against or action brought by the Indemnitee
for (i) indemnification or advance payment of Expenses by the Company under this
Agreement or any other agreement or Company By-law or provision of the Company's
Restated Certificate of Incorporation now or hereafter in effect relating to
Claims for

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Indemnifiable Events or (ii) recovery under any directors' and officers'
liability insurance policies maintained by the Company, regardless of whether
the Indemnitee ultimately is determined to be entitled to such indemnification,
advance expense payment or insurance recovery, as the case may be.

         6. PARTIAL INDEMNITY, ETC. If the Indemnitee is entitled under any
provision of this Agreement to indemnification by the Company for a portion of
the Expenses, judgments, fines, penalties and amounts paid in settlement of a
Claim but not for the total amount thereof, the Company shall indemnify the
Indemnitee for the portion thereof to which the Indemnitee is entitled.
Notwithstanding any other provision of this Agreement, to the extent that the
Indemnitee has been successful on the merits or otherwise in defense of Claims
relating to an Indemnifiable Event or in defense of any issue or matter therein,
including dismissal without prejudice, the Indemnitee shall be indemnified
against all Expenses incurred in connection therewith.

         7. BURDEN OF PROOF. In connection with any determination by the
Reviewing Party or otherwise as to whether the Indemnitee is entitled to be
indemnified hereunder, the burden of proof shall be on the Company to establish
that the Indemnitee is not so entitled.

         8. NO PRESUMPTION. For purposes of this Agreement, the termination of
any claim, action, suit or proceeding, by judgment, order, settlement (whether
with or without court approval) or conviction, or upon a plea of nolo
contendere, or its equivalent, shall not create a presumption that the
Indemnitee did not meet any particular standard of conduct or have any
particular belief or that a court has determined that indemnification is not
permitted by applicable law. In addition, neither the failure of the Reviewing
Party to have made a determination as to whether the Indemnitee has met any
particular standard of conduct or had any particular belief, nor an actual
determination by the Reviewing Party that the Indemnitee has not met such
standard of conduct or did not have such belief, prior to the commencement of
legal proceedings by the Indemnitee to secure a judicial determination that the
Indemnitee should be indemnified under applicable law shall be a defense to the
Indemnitee's claim or create a presumption that the Indemnitee has not met any
particular standard of conduct or did not have any particular belief.

         9. NON-EXCLUSIVITY, ETC. The rights of the Indemnitee hereunder shall
be in addition to any other rights the Indemnitee may have under the Company's
Restated Certificate of Incorporation and By-laws or the Delaware General
Corporation Law or otherwise. To the extent that a change in the Delaware
General Corporation Law (whether by statute or judicial decision) permits
greater indemnification by agreement than would be afforded currently under the
Company's Restated Certificate of Incorporation and By-laws and this Agreement,
it is the intent of the parties hereto that the Indemnitee shall enjoy by this
Agreement the greater benefits afforded by such change.

         10. LIABILITY INSURANCE. To the extent the Company maintains an
insurance policy or policies providing directors' and officers' liability
insurance, the Indemnitee shall be covered by such policy or policies, in
accordance with its or their terms, to the maximum extent of the coverage
available for any Company director or officer.

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         11. AMENDMENTS, ETC. No supplement, modification or amendment of this
Agreement shall be binding unless executed in writing by both of the parties
hereto. No waiver of any of the provisions of this Agreement shall constitute a
waiver of any other provisions hereof (whether or not similar) nor shall such
waiver constitute a continuing waiver.

         12. SUBROGATION. In the event of payment under this Agreement, the
Company shall be subrogated to the extent of such payment to all of the rights
of recovery of the Indemnitee, who shall execute all such papers and do all such
things as may be necessary or desirable to secure such rights.

         13. NO DUPLICATION OF PAYMENTS. The Company shall not be liable under
this Agreement to make any payment in connection with any Claim made against the
Indemnitee to the extent the Indemnitee has otherwise received payment (under
any insurance policy, provision of the Company's Restated Certificate of
Incorporation, Company By-law or otherwise) of the amounts otherwise
indemnifiable hereunder.

         14. BINDING EFFECT, ETC. This Agreement shall be binding and inure to
the benefit of and be enforceable by the parties hereto and their respective
successors, assigns, including any direct or indirect successor by purchase,
merger, consolidation or otherwise to all or substantially all of the business
or assets of the Company, spouses, heirs, and personal and legal
representatives. The Company shall require any successor (whether direct or
indirect, by purchase, merger, consolidation, liquidation or otherwise) to all
or substantially all of the business or assets of the Company by written
agreement expressly to assume and agree to perform this Agreement in the same
manner and to the same extent that the Company would be required to perform it
if no such succession had taken place. As used in this Agreement, "Company"
shall mean the Company as hereinbefore defined and any successor to its business
or assets aforesaid which assumes and agrees to perform this Agreement by
operation of law, or otherwise. This Agreement shall continue in effect
regardless of whether the Indemnitee continues to serve as an officer or
director of the Company or of any other enterprise at the Company's request.

         15. SEVERABILITY. The provisions of this Agreement shall be severable
in the event that any of the provisions hereof (including any provision within a
single section, paragraph or sentence) are held by a court of competent
jurisdiction to be invalid, void or otherwise unenforceable, and the remaining
provisions shall remain enforceable to the fullest extent permitted by law.

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         16. GOVERNING LAW. This Agreement shall be governed by and construed
and enforced in accordance with the laws of the State of Delaware applicable to
contracts made and to be performed in such state without giving effect to the
principles of conflicts of laws.

                                           EPIX PHARMACEUTICALS, INC.

                                           By:
                                              ---------------------------------
                                           Title
                                               --------------------------------

                                           ------------------------------------
                                                       (Indemnitee)

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