Document:

exv10w22wii

Exhibit
10.22(ii)

10513 W. 84th Terrace

 Lenexa, KS
66214 

P: 913.685.8850 

F: 913.685.8856

www.cydexpharma.com

April 19, 2011

Via Federal Express

Onyx Pharmaceuticals 

2100
Powell Street 
Emeryville,
California 94608

Attention: VP, Development

			
	     Re:	 	Exhibit A to the License and Supply Agreement dated as of October 12,
2005, as amended (“Agreement”) between CyDex Pharmaceuticals, Inc.
(formerly known as CyDex, Inc., “CyDex”) Onyx Pharmaceuticals
(formerly known as Proteolix, Inc. (“Company”)

Dear Sir or Madam:

     Pursuant to Section 1.20 of the Agreement, CyDex has the right and obligation to update
Exhibit A to the Agreement which lists the “Licensed Patents” which cover Captisol®. This letter is
provided by CyDex to Company as an official notice pursuant to Section 14.7 of the Agreement to so
update such Exhibit A.

     Accordingly, listed in Schedule A, attached hereto, is the complete list of all patents and
patent applications, which hereby replaces the existing definition of Licensed Patents.

     Please contact the undersigned if you have any questions.

With best regards,

CYDEX PHARMACEUTICALS, INC.

Allen K. Roberson, General Manager

Enclosure

1

 

Schedule A

PATENT FAMILY 1: “Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof.”

Issued Patents

	 	 	 	 	 	 	 	 	 
	 	 	Filing Date	 	 	 	 	 	Expiration Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Patent No.	 	(mm/dd/yyyy)
	United States
	 	01/23/1990
	 	07/469,087
	 	5,134,127
	 	01/23/2010
	Australia
	 	01/22/1991
	 	72364/91
	 	646020
	 	01/22/2011
	Austria
	 	01/22/1991
	 	91903891.9
	 	E 170742
	 	01/22/2011
	Belgium
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	Canada
	 	01/22/1991
	 	2,074,186
	 	2,074,186
	 	01/22/2011
	Europe
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	France
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	Germany
	 	01/22/1991
	 	6030165.4-08
	 	69130165
	 	01/22/2011
	Greece
	 	01/22/1991
	 	980402865
	 	3028691
	 	01/22/2011
	Italy
	 	01/22/1991
	 	70988BE/98
	 	512050
	 	01/22/2011
	Japan
	 	01/22/1991
	 	504051/93
	 	2722277
	 	01/22/2011
	Luxembourg
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	Netherlands
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	Russia
	 	01/22/1991
	 	5052811.04
	 	2099354
	 	01/22/2011
	South Korea
	 	01/22/1991
	 	92-701734
	 	166088
	 	01/22/2011
	Sweden
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	Switzerland
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011
	United Kingdom
	 	01/22/1991
	 	91903891.9
	 	512050
	 	01/22/2011

PATENT FAMILY 2: “Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof.”

Issued Patents

	 	 	 	 	 	 	 	 	 
	 	 	Filing Date	 	 	 	 	 	Expiration Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Patent No.	 	(mm/dd/yyyy)
	United States
	 	07/27/1992
	 	07/918,702
	 	5,376,645
	 	01/23/2010
	Armenia
	 	07/26/1993
	 	96237
	 	822
	 	07/26/2013
	Australia
	 	07/26/1993
	 	47799/93
	 	672814
	 	07/26/2013
	Austria
	 	07/26/1993
	 	93918302
	 	E 217325
	 	07/26/2013

2

 

	 	 	 	 	 	 	 	 	 
	 	 	Filing Date	 	 	 	 	 	Expiration Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Patent No.	 	(mm/dd/yyyy)
	Belgium
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Canada
	 	07/26/1993
	 	2,119,154
	 	2,119,154
	 	07/26/2013
	Denmark
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Europe
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	France
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Georgia
	 	07/26/1993
	 	1857
	 	1649
	 	07/26/2013
	Germany
	 	07/26/1993
	 	6031900
	 	69331900
	 	07/26/2013
	Greece
	 	07/26/1993
	 	930620828
	 	3040489
	 	07/26/2013
	Ireland
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Italy
	 	07/26/1993
	 	70422BE/2002
	 	620828
	 	07/26/2013
	Japan
	 	07/26/1993
	 	6-504678/94
	 	3393253
	 	07/26/2013
	Kyrgyzstan
	 	07/26/1993
	 	960481.1
	 	333
	 	07/26/2013
	Luxembourg
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Moldova
	 	07/26/1993
	 	960306
	 	1813
	 	07/26/2013
	Monaco
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Netherlands
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Portugal
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Russia
	 	07/26/1993
	 	94028890
	 	2113442
	 	07/26/2013
	South Korea
	 	07/26/1993
	 	94-700951
	 	279111
	 	07/26/2013
	Spain
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Sweden
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Switzerland
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Tajikistan
	 	07/26/1993
	 	96000377
	 	TJ 275
	 	07/26/2013
	Turkmenistan
	 	07/26/1993
	 	393
	 	430
	 	07/26/2013
	United Kingdom
	 	07/26/1993
	 	93918302.6
	 	620828
	 	07/26/2013
	Uzbekistan
	 	07/26/1993
	 	IHAP9400808
	 	5799
	 	07/26/2013

PATENT FAMILY 15: “Sulfoalkyl Ether Cyclodextrin Compositions and Methods of Preparation Thereof.”

Issued Patents

	 	 	 	 	 	 	 	 	 
	 	 	Filing Date	 	 	 	 	 	Expiration Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Patent No.	 	(mm/dd/yyyy)
	United States
	 	01/31/2009
	 	12/363,719
	 	7,629,331
	 	10/26/2025
	Europe*
	 	10/26/2005
	 	05856927.8
	 	1945228
	 	10/26/2025

3

 

Pending Applications

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Estimated Expiration
	 	 	Filing Date	 	 	 	 	 	Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Publication No.	 	(mm/dd/yyyy)
	United States
	 	10/26/2005
	 	12/108,228
	 	2009/0011037
	 	10/26/2025
	Australia
	 	10/26/2005
	 	2005337613
	 	2005337613
	 	10/26/2025
	Brazil
	 	10/26/2005
	 	PI0520654-5
	 	Brazilian Industrial
Property Journal No.
2002
	 	10/26/2025
	Canada
	 	10/26/2005
	 	2,632,211
	 	2,632,211
	 	10/26/2025
	China
	 	10/26/2005
	 	200580052421.8
	 	101365459A
	 	10/26/2025
	India
	 	10/26/2005
	 	3462/DELNP/2008
	 	Not yet published
	 	10/26/2025
	Israel
	 	10/26/2005
	 	191081
	 	Not yet published
	 	10/26/2025
	Japan
	 	10/26/2005
	 	2008-537669
	 	2009-513773
	 	10/26/2025
	Mexico
	 	10/26/2005
	 	MX/a/2008/005397
	 	Not yet published
	 	10/26/2025
	South
Korea
	 	10/26/2005
	 	10-2008-7012541
	 	10-20080063526
	 	10/26/2025
	Russia
	 	10/26/2005
	 	2008120659
	 	2008120659
	 	10/26/2025

 

			
	*	 	The grant date of EP 1945228 will be 04/06/2011.

PATENT FAMILY 20: “Sulfoalkyl Ether Cyclodextrin Compositions”

Issued Patents

	 	 	 	 	 	 	 	 	 
	 	 	Filing Date	 	 	 	 	 	Expiration Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Patent No.	 	(mm/dd/yyyy)
	United States
	 	03/13/2009
	 	12/404,174
	 	7,635,773
	 	03/13/2029

Pending Applications

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Estimated Expiration
	 	 	Filing Date	 	 	 	 	 	Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Publication No.	 	(mm/dd/yyyy)
	United States
	 	11/05/2009
	 	12/613,103
	 	2010/0093663
	 	03/13/2029
	Australia
	 	04/28/2009
	 	2009241858
	 	Not yet published
	 	04/28/2029
	Brazil
	 	04/28/2009
	 	PI0905080-9
	 	Not yet published
	 	04/28/2029
	Canada
	 	04/28/2009
	 	2,702,603
	 	Not yet published
	 	04/28/2029
	China
	 	04/28/2009
	 	200980107665.X
	 	101959508
	 	04/28/2029

4

 

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	Estimated Expiration
	 	 	Filing Date	 	 	 	 	 	Date
	Country	 	(mm/dd/yyyy)	 	Application No.	 	Publication No.	 	(mm/dd/yyyy)
	Eurasia
	 	04/28/2009
	 	201000828
	 	Not yet published
	 	04/28/2029
	Europe
	 	04/28/2009
	 	09739150.2
	 	2268269
	 	04/28/2029
	India
	 	04/28/2009
	 	To be determined
	 	Not yet published
	 	04/28/2029
	Israel
	 	04/28/2009
	 	208956
	 	Not yet published
	 	04/28/2029
	Japan
	 	04/28/2009
	 	2010-525119
	 	2010-539193
	 	04/28/2029
	Mexico
	 	04/28/2009
	 	MX/a/2010/004900
	 	MX/a/2010/004900
	 	04/28/2029
	South Korea
	 	04/28/2009
	 	10-2010-7026534
	 	Not yet published
	 	04/28/2029
	New Zealand
	 	04/28/2009
	 	589290
	 	Not yet published
	 	04/28/2029

5exv4w1

 

    Exhibit 4.1

    English Translation of Chinese Original

 

    Year 2011
    Performance Contract with Management of PetroChina Company
    Limited

 

	 	 	 	 	 	 	 
	

    Offeree: Name: ZHOU, Jiping

	
 
	
 
	
    Offeror: Name: JIANG, Jiemin
	
 
	
 
	
    Term of the Contract: January 1, 2011 to December 31, 2011

	
 
	
 
	
 
	
 
	
 
	
 
	
 

	

    Title:  President of PetroChina Company Limited

    (“PetroChina”)

	
 
	
 
	

    Title:  Chairman of the Board of Directors of

    PetroChina

	
 
	
 
	
    Date of Execution:
              ,
    2011

	
 
	
 
	
 
	
 
	
 
	
 
	
 

 

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
    Departments

    

	
 
	
 
	
 
	
    Key Performance

    
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
    Actual

    
	
 
	
 
	
    Providing the

    

	
    Indices
	
 
	
 
	
    Indices (KPI)
	
 
	
 
	
    Weight (%)
	
 
	
 
	
    Measurement
	
 
	
 
	
    Target
	
 
	
 
	
    Performance
	
 
	
 
	
    Numbers

	

Profits Indices

85%

	
 
	
 
	
    Rate of return of the

    invested capital

    (ROIC)
	
 
	
 
	
    30
	
 
	
 
	
    %
	
 
	
 
	
    8.8
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Economic value

    added (EVA)
	
 
	
 
	
    10
	
 
	
 
	
    In 100 million RMB
	
 
	
 
	
    462.5
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Net income (NI)
	
 
	
 
	
    10
	
 
	
 
	
    In 100 million RMB
	
 
	
 
	
    1167.9
	
 
	
 
	
 
	
 
	
 
	
    Budget Management

    Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Free cash flow (FCF)
	
 
	
 
	
    15
	
 
	
 
	
    In 100 million RMB
	
 
	
 
	
    -923.8
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Domestic full cost for

    oil
	
 
	
 
	
    5
	
 
	
 
	
    US$/barrel
	
 
	
 
	
    27.18 (of which, the unit oil

    and gas lifting cost shall be

    US$10.48)
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Full processing cost for

    oil
	
 
	
 
	
    5
	
 
	
 
	
    RMB/ton
	
 
	
 
	
    225.0
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Marketing cost for oil
	
 
	
 
	
    5
	
 
	
 
	
    RMB/ton
	
 
	
 
	
    289.45
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Gap between the

    actual capital

    expenditure and

    budget
	
 
	
 
	
    5
	
 
	
 
	
    %
	
 
	
 
	
    ±5
	
 
	
 
	
 
	
 
	
 
	
    Planning Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	

Operating Indices

15%

	
 
	
 
	
    Rate of crude oil

    reserves replacement
	
 
	
 
	
    10
	
 
	
 
	
 
	
 
	
 
	

oil: 1

natural gas: 2 (domestic
standard)

	
 
	
 
	
 
	
 
	
 
	
    Planning Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Energy and water

    conservation
	
 
	
 
	
    5
	
 
	
 
	
    10,000 cubic

    meter/10,000 TCE
	
 
	
 
	

Energy conservation: 90

Water conservation: 1600

	
 
	
 
	
 
	
 
	
 
	
    Quality Management

    and Energy

    Conservation

    Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	

    Indices for control

	
 
	
 
	
    Safety and

    environmental

    protection
	
 
	
 
	
    employee death
    £
    0.0204 person/million manhours

    

    extraordinarily serious safe production accidents = 0; and

    

    extraordinarily serious environmental accidents=0.
	
 
	
 
	
    Comprehensive

    performance expressed in

    marks to be increased by 5

    marks if achieving the target

    for the relevant index for

    control, and to be reduced

    by 5 marks if failing to

    achieve the target for the

    relevant index for control.
	
 
	
 
	
    Safety and

    Environmental

    Protection

    Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

	
 
	
 
	
 
	
    Internal control
	
 
	
 
	
    Meeting the requirement
	
 
	
 
	
 
	
 
	
 
	
    Internal Control and

    Risk Management

    Department

	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

 

				
	    Signature
    of Offeree: ZHOU JIping
    	    
    Signature of Offeror: JIANG Jiemin

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00189-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00189-of-00352.parquet"}]]