Document:

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                                                                   Exhibit 10.60

                              AMENDED AND RESTATED
                     EXECUTIVE SEVERANCE BENEFITS AGREEMENT

         This Amended and Restated Executive Severance Benefits Agreement (the
"Agreement") is entered into this 31/st/ day of December, 2002 (the "Effective
Date"), between Andrew A. Wolff ("Executive") and CV Therapeutics, Inc. (the
"Company"). This Agreement is intended to provide Executive with the
compensation and benefits described herein upon the occurrence of specific
events. Certain capitalized terms used in this Agreement are defined in Article
6.

         The Company and Executive hereby agree as follows:

                                    ARTICLE 1

                  Scope of and Consideration for this Agreement

         1.1      Current Employee.  Executive is currently employed by the
Company.

         1.2      Benefits Upon Change In Control. The Company and Executive
wish to set forth the compensation and benefits which Executive shall be
entitled to receive in the event of a Change in Control or if Executive's
employment with the Company is terminated under the circumstances described
herein following a Change in Control.

         1.3      Consideration. The duties and obligations of the Company to
Executive under this Agreement shall be in consideration for Executive's past
services to the Company, Executive's continued employment with the Company, and
Executive's execution of a release in accordance with Section 4.1.

         1.4      Prior Agreement. This Agreement shall supersede any other
agreement relating to cash severance benefits and health benefits in the event
of Executive's severance from employment with the Company following a Change in
Control, including that certain Executive Severance Benefits Agreement between
the Company and Executive dated as of February 2, 1999 (the "Prior Agreement").
By executing this Agreement, Executive hereby waives (within the meaning of
Section 6.4 of the Prior Agreement) any rights Executive may currently have or
have in the future to any benefits of any sort under the Prior Agreement.

                                    ARTICLE 2

                   Option Acceleration Upon Change in Control

         In the event of a Change in Control, all options of Executive to
purchase the Company's common stock (or the stock of a successor to the Company
by reason of assumption or substitution of options) then outstanding shall,
automatically and without further action of the Company, become one hundred
percent (100%) vested and exercisable, and any restrictions with respect to
restricted shares of the Company's capital stock (or the stock of a successor to
the Company by reason of assumption or substitution of such shares) that
Executive then holds shall,

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automatically and without further action of the Company, lapse, in the case of
all such options and/or restrictions no later than five (5) business days before
the effective date of such Change in Control.

                                    ARTICLE 3

                               Severance Benefits

         3.1      Severance Benefits. If Executive's employment terminates due
to an Involuntary Termination Without Cause or a Constructive Termination, in
any such case occurring within thirteen (13) months following the effective date
of a Change in Control, such termination of employment will be deemed a Covered
Termination. A Covered Termination entitles Executive to receive the following
benefits set forth in Sections 3.2, 3.3 and 3.4.

         3.2      Base Salary. The Company shall pay to Executive an amount
equal to eighteen (18) months' Base Salary. Such severance amount shall be paid
in cash in a lump sum within thirty (30) days following the Covered Termination
and shall be subject to all required tax withholding.

         3.3      Bonus. The Company shall pay to Executive an amount equal to
one hundred and fifty percent (150%) of the annual bonus paid to the Executive
in the year immediately preceding the effective date of the Change in Control.
Such severance amount shall be paid in cash in a lump sum within thirty (30)
days following the Covered Termination and shall be subject to all required tax
withholding.

         3.4      Health Benefits. Provided that Executive elects continued
coverage under federal COBRA law, the Company shall pay the premiums of
Executive's group health insurance coverage, including coverage for Executive's
eligible dependents, for a maximum period of eighteen (18) months following a
Covered Termination; provided, however, that the Company shall pay premiums for
Executive's eligible dependents only for coverage for which those eligible
dependents were enrolled immediately prior to the Covered Termination. No
premium payments will be made following the effective date of Executive's
coverage by a health insurance plan of a subsequent employer. For the balance of
the period that Executive is entitled to coverage under federal COBRA law, if
any, Executive shall be entitled to maintain such coverage at Executive's own
expense.

         3.5      Mitigation. Except as otherwise specifically provided herein,
Executive shall not be required to mitigate damages or the amount of any payment
provided under this Agreement by seeking other employment or otherwise, nor
shall the amount of any payment provided for under this Agreement be reduced by
any compensation earned by Executive as a result of employment by another
employer or by any retirement benefits received by Executive after the date of
the Covered Termination.

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                                    ARTICLE 4

                     Limitations And Conditions On Benefits

         4.1      Release Prior To Payment Of Benefits. Upon the occurrence of a
Covered Termination, and prior to the payment of any benefits under this
Agreement on account of such Covered Termination, Executive shall execute a
release (the "Release") in the form attached hereto and incorporated herein as
Exhibit A or Exhibit B, as applicable. Such Release shall specifically relate to
all of Executive's rights and claims in existence at the time of such execution
and shall confirm Executive's obligations under the Company's standard form of
proprietary information and inventions agreement. It is understood that, as
specified in the applicable Release, Executive has a certain number of calendar
days to consider whether to execute such Release, and Executive may revoke such
Release within seven (7) calendar days after execution. In the event Executive
does not execute such Release within the applicable period, or if Executive
revokes such Release within the subsequent seven (7) day period, no benefits
shall be payable under this Agreement, and this Agreement shall be null and
void.

         4.2      Termination of Benefits. Benefits under this Agreement shall
terminate immediately if the Executive, at any time, violates any proprietary
information or confidentiality obligation to the Company.

         4.3      Non-Duplication of Benefits.  Executive is not eligible to
receive benefits under this Agreement more than one time.

                                    ARTICLE 5

                               Parachute Payments

         5.1      Certain Additional Payments by the Company. Anything in this
Agreement to the contrary notwithstanding and except as set forth below, in the
event it shall be determined that any Payment would be subject to the Excise
Tax, then the Executive shall be entitled to receive from the Company an
additional payment (the "Gross-Up Payment") in an amount such that the net
amount of the Payment and the Gross-Up Payment retained by the Executive after
the payment by the Executive of all Excise Taxes (including any interest or
penalties imposed with respect to such taxes) on the Payment and all federal,
state and local income tax, employment tax and Excise Taxes (including any
interest or penalties imposed with respect to such taxes) on the Gross-Up
Payment shall be equal to the Payment.

         5.2      Determinations. Subject to the provisions of Section 5.3, all
determinations required to be made under this Article 5, including whether and
when a Gross-Up Payment is required and the amount of such Gross-Up Payment and
the assumptions to be utilized in arriving at such determination, shall be made
by the nationally recognized certified public accounting firm used by the
Company immediately prior to the effective date of the Change in Control or, if
such firm declines to serve, such other nationally recognized certified public
accounting firm as may be designated by the Executive (the "Accounting Firm").
The Accounting Firm shall provide detailed supporting calculations both to the
Company and the Executive within fifteen (15) business days of the receipt of
notice from the Executive that there

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has been a Payment, or such earlier time as is requested by the Company. All
fees and expenses of the Accounting Firm shall be borne solely by the Company.
Any determination by the Accounting Firm shall be binding upon the Company and
the Executive. Subject to Section 5.5 below, any Gross-Up Payment, as determined
pursuant to this Section 5.2, shall be paid by the Company to the Executive
within five (5) days of the receipt of the Accounting Firm's determination. For
purposes of making the calculations required by this Article 5, the Accounting
Firm may make reasonable assumptions and approximations concerning applicable
taxes and may rely on reasonable, good-faith interpretations concerning the
application of Sections 280G and 4999 of the Code. As a result of the
uncertainty in the application of Section 4999 of the Code at the time of the
initial determination by the Accounting Firm hereunder, it is possible that
Gross-Up Payments which will not have been made by the Company should have been
made ("Underpayment"), consistent with the calculations required to be made
hereunder. In the event that the Company exhausts its remedies pursuant to
Section 5.3 and the Executive thereafter is required to make a payment of any
Excise Tax, the Accounting Firm shall determine the amount of the Underpayment
that has occurred and any such Underpayment shall be promptly paid by the
Company to or for the benefit of the Executive.

         5.3      Contesting of Gross-Up Payment. The Executive shall notify the
Company in writing of any claim by the Internal Revenue Service that, if
successful, would require the payment by the Company of the Gross-Up Payment.
Such notification shall be given as soon as practicable but no later than ten
(10) business days after the Executive is informed in writing of such claim and
shall apprise the Company of the nature of such claim and the date on which such
claim is requested to be paid. The Executive shall not pay such claim prior to
the expiration of the thirty (30)-day period following the date on which it
gives such notice to the Company (or such shorter period ending on the date that
any payment of taxes with respect to such claim is due). If the Company notifies
the Executive in writing prior to the expiration of such period that it desires
to contest such claim, the Executive shall:

                  (a)      give the Company any information reasonably requested
by the Company relating to such claim,

                  (b)      take such action in connection with contesting such
claim as the Company shall reasonably request in writing from time to time,
including, without limitation, accepting legal representation with respect to
such claim by an attorney reasonably selected by the Company,

                  (c)      cooperate with the Company in good faith in order
effectively to contest such claim, and

                  (d)      permit the Company to participate in any proceedings
relating to such claim;

provided, however, that the Company shall bear and pay directly all costs and
expenses (including additional interest and penalties) incurred in connection
with such contest and shall indemnify and hold the Executive harmless, on an
after-tax basis, for any Excise Tax or income tax (including interest and
penalties with respect thereto) imposed as a result of such representation and
payment of costs and expenses. Without limitation on the foregoing

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provisions of this Section 5.3, the Company shall control all proceedings taken
in connection with such contest and, at its sole option, may pursue or forgo any
and all administrative appeals, proceedings, hearings and conferences with the
taxing authority in respect of such claim and may, at its sole option, either
direct the Executive to pay the tax claimed and sue for a refund or contest the
claim in any permissible manner, and the Executive agrees to prosecute such
contest to a determination before any administrative tribunal, in a court of
initial jurisdiction and in one or more appellate courts, as the Company shall
determine; provided, however, that if the Company directs the Executive to pay
such claim and sue for a refund, the Company shall advance the amount of such
payment to the Executive, on an interest-free basis and shall indemnify and hold
the Executive harmless, on an after-tax basis, from any Excise Tax or income tax
(including interest or penalties with respect thereto) imposed with respect to
such advance or with respect to any imputed income with respect to such advance;
and provided further, however, that any extension of the statute of limitations
relating to payment of taxes for the taxable year of the Executive with respect
to which such contested amount is claimed to be due is limited solely to such
contested amount. Furthermore, the Company's control of the contest shall be
limited to issues with respect to which a Gross-Up Payment would be payable
hereunder and the Executive shall be entitled to settle or contest, as the case
may be, any other issue raised by the Internal Revenue Service or any other
taxing authority.

         5.4      Refunds. If, after the receipt by the Executive of an amount
advanced by the Company pursuant to Section 5.3, the Executive becomes entitled
to receive any refund with respect to such claim, the Executive shall (subject
to the Company's complying with the requirements of Section 5.3) promptly pay to
the Company the amount of such refund (together with any interest paid or
credited thereon after taxes applicable thereto). If, after the receipt by the
Executive of an amount advanced by the Company pursuant to Section 5.3, a
determination is made that the Executive shall not be entitled to any refund
with respect to such claim and the Company does not notify the Executive in
writing of its intent to contest such denial of refund prior to the expiration
of thirty (30) days after such determination, then such advance shall be
forgiven and shall not be required to be repaid and the amount of such advance
shall offset, to the extent thereof, the amount of Gross-Up Payment required to
be paid.

         5.5      Withholding. Notwithstanding any other provision of this
Article 5, the Company may withhold and pay over to the Internal Revenue Service
for the benefit of the Executive all or any portion of the Gross-Up Payment that
it determines in good faith that it is or may be in the future required to
withhold, and the Executive hereby consents to such withholding.

                                    ARTICLE 6

                                   Definitions

         For purposes of the Agreement, the following terms are defined as
follows:

         6.1      "Base Salary" means Executive's annual base salary as in
effect during the last regularly scheduled payroll period immediately preceding
the Covered Termination.

         6.2      "Board" means the Board of Directors of the Company.

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         6.3      "Cause" means that, in the reasonable determination of the
Company, Executive:

                  (a)      has committed an act that materially injures the
business of the Company;

                  (b)      has refused or failed to follow lawful and reasonable
directions of the Board or the appropriate individual to whom Executive reports;

                  (c)      has willfully or habitually neglected Executive's
duties for the Company; or

                  (d)      has been convicted of a felony involving moral
turpitude that is likely to inflict or has inflicted material injury on the
business of the Company.

         Notwithstanding the foregoing, Cause shall not exist based on conduct
described in clause (b) or clause (c) unless the conduct described in such
clause has not been cured within fifteen (15) days following Executive's receipt
of written notice from the Company or the Board, as the case may be, specifying
the particulars of the conduct constituting Cause.

         6.4      "Change in Control" means

                  (a)      a sale of substantially all of the assets of the
Company;

                  (b)      a merger or consolidation in which the Company is not
the surviving corporation (other than a merger or consolidation in which
shareholders immediately before the merger or consolidation have, immediately
after the merger or consolidation, equal or greater stock voting power);

                  (c)      a reverse merger in which the Company is the
surviving corporation but the shares of the Company's common stock outstanding
immediately preceding the merger are converted by virtue of the merger into
other property, whether in the form of securities, cash or otherwise (other than
a reverse merger in which shareholders immediately before the merger have,
immediately after the merger, greater stock voting power); or

                  (d)      any transaction or series of related transactions in
which in excess of 50% of the Company's  voting power is transferred.

         6.5      "Code" means the Internal Revenue Code of 1986, as amended.

         6.6      "Company" means CV Therapeutics, Inc. or,  following a Change
in Control,  the surviving entity resulting from such transaction.

         6.7      "Constructive Termination" means that Executive voluntarily
terminates employment within thirteen (13) months following the effective date
of a Change in Control after any of the following are undertaken without
Executive's express written consent:

                  (a)      the assignment to Executive of any duties or
responsibilities which results in a significant diminution in Executive's
function as in effect immediately prior to the effective

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date of the Change in Control; provided, however, that a mere change in
Executive's title or reporting relationships shall not constitute a Constructive
Termination;

                  (b)      a reduction by the Company in Executive's annual base
salary, as in effect on the effective date of the Change in Control or as
increased thereafter;

                  (c)      any failure by the Company to continue in effect any
benefit plan or program, including fringe benefits, incentive plans and plans
with respect to the receipt of securities of the Company, in which Executive is
participating immediately prior to the effective date of the Change in Control
(hereinafter referred to as "Benefit Plans"); or the taking of any action by the
Company that would adversely affect Executive's participation in or reduce
Executive's benefits under the Benefit Plans; provided, however, that a
"Constructive Termination" shall not exist under this paragraph following a
Change in Control if the Company offers a range of benefit plans and programs
which, taken as a whole, are comparable to the Benefit Plans;

                  (d)      a relocation of Executive's business office to a
location more than twenty (20) miles from the location at which Executive
performs duties as of the effective date of the Change in Control, except for
required travel by Executive on the Company's business to an extent
substantially consistent with Executive's business travel obligations prior to
the Change in Control; provided, however, that if Executive performs sales
functions for the Company, a change of sales territory shall not constitute a
basis for Constructive Termination so long as the Executive's business office is
not relocated as provided above;

                  (e)      a material breach by the Company of any provision of
this Agreement; or

                  (f)      any failure by the Company to obtain the assumption
of this Agreement by any successor or assign of the Company.

The termination of Executive's employment as a result of Executive's death or
disability will not be deemed to be a Constructive Termination.

         6.8      "Covered Termination" means an Involuntary Termination Without
Cause or a Constructive Termination, in any such case occurring within thirteen
(13) months following the effective date of a Change in Control.

         6.9      "Excise Tax" shall mean the excise tax imposed by Section 4999
of the Code, together with any interest or penalties imposed with respect to
such excise tax.

         6.10     "Involuntary Termination Without Cause" means Executive's
dismissal or discharge other than for Cause. The termination of Executive's
employment as a result of Executive's death or disability will not be deemed to
be an Involuntary Termination Without Cause.

         6.11     A "Payment" shall mean any payment or distribution in the
nature of compensation (within the meaning of Section 280G(b)(2) of the Code) to
or for the benefit of the Executive, whether paid or payable pursuant to this
Agreement or otherwise.

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                                    ARTICLE 7

                               General Provisions

         7.1      Employment Status. This Agreement does not constitute a
contract of employment or impose upon Executive any obligation to remain as an
employee, or impose on the Company any obligation (i) to retain Executive as an
employee, (ii) to change the status of Executive as an at-will employee, or
(iii) to change the Company's policies regarding termination of employment.

         7.2      Notices. Any notices provided hereunder must be in writing,
and such notices or any other written communication shall be deemed effective
upon the earlier of personal delivery (including personal delivery by facsimile)
or the third day after mailing by first class mail, to the Company at its
primary office location and to Executive at Executive's address as listed in the
Company's payroll records. Any payments made by the Company to Executive under
the terms of this Agreement shall be delivered to Executive either in person or
at the address as listed in the Company's payroll records.

         7.3      Severability. Whenever possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held to be invalid,
illegal or unenforceable in any respect under any applicable law or rule in any
jurisdiction, such invalidity, illegality or unenforceability will not affect
any other provision or any other jurisdiction, but this Agreement will be
reformed, construed and enforced in such jurisdiction as if such invalid,
illegal or unenforceable provisions had never been contained herein.

         7.4      Waiver. If either party should waive any breach of any
provisions of this Agreement, he or it shall not thereby be deemed to have
waived any preceding or succeeding breach of the same or any other provision of
this Agreement.

         7.5      Arbitration. Unless otherwise prohibited by law or specified
below, all disputes, claims and causes of action, in law or equity, arising from
or relating to this Agreement or its enforcement, performance, breach, or
interpretation shall be resolved solely and exclusively by final and binding
arbitration held in San Francisco County, California through Judicial
Arbitration & Mediation Services/Endispute ("JAMS") under the then existing JAMS
arbitration rules. However, nothing in this Section is intended to prevent
either party from obtaining injunctive relief in court to prevent irreparable
harm pending the conclusion of any such arbitration. The Company will pay the
direct costs and expenses of any such arbitration, including the fees and costs
of the arbitrator. Each party in any such arbitration shall be responsible for
its own attorneys' fees and related costs and necessary disbursements; provided,
however, that in the event one party refuses to arbitrate and the other party
seeks to compel arbitration by court order, if such other party prevails, except
as may be prohibited by law, it shall be entitled to recover reasonable
attorneys' fees and related costs and necessary disbursements. Pursuant to
California Civil Code Section 1717, each party warrants that it was represented
by counsel in the negotiation and execution of this Agreement, including the
attorneys' fees provision herein.

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         7.6      Complete Agreement. This Agreement, including Exhibit A and
Exhibit B, constitutes the entire agreement between Executive and the Company
and is the complete, final, and exclusive embodiment of their agreement with
regard to this subject matter, wholly superseding all written and oral
agreements with respect to cash severance benefits and health benefits to
Executive in the event of employment termination (including the Prior Agreement)
other than any outstanding loans by the Company to Executive. It is entered into
without reliance on any promise or representation other than those expressly
contained herein.

         7.7      Amendment Or Termination Of Agreement. This Agreement may be
changed or terminated only upon the mutual written consent of the Company and
Executive. The written consent of the Company to a change or termination of this
Agreement must be signed by an executive officer of the Company after such
change or termination has been approved by the Board.

         7.8      Counterparts. This Agreement may be executed in separate
counterparts, any one of which need not contain signatures of more than one
party, but all of which taken together will constitute one and the same
Agreement.

         7.9      Headings. The headings of the Articles and Sections hereof are
inserted for convenience only and shall not be deemed to constitute a part
hereof nor to affect the meaning thereof.

         7.10     Successors And Assigns. This Agreement is intended to bind and
inure to the benefit of and be enforceable by Executive, and the Company, and
any surviving entity resulting from a Change in Control and upon any other
person who is a successor by merger, acquisition, consolidation or otherwise to
the business formerly carried on by the Company, and their respective
successors, assigns, heirs, executors and administrators, without regard to
whether or not such person actively assumes any rights or duties hereunder;
provided, however, that Executive may not assign any duties hereunder and may
not assign any rights hereunder without the written consent of the Company,
which consent shall not be withheld unreasonably.

         7.11     Choice Of Law. All questions concerning the construction,
validity and interpretation of this Agreement will be governed by the law of the
State of California, without regard to such state's conflict of laws rules.

         7.12     Non-Publication. The parties mutually agree not to disclose
publicly the terms of this Agreement except to the extent that disclosure is
mandated by applicable law or regulation or to respective advisors (e.g.,
attorneys, accountants).

         7.13     Construction Of Agreement. In the event of a conflict between
the text of the Agreement and any summary, description or other information
regarding the Agreement, the text of the Agreement shall control.

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         In Witness Whereof, the parties have executed this Agreement on the
Effective Date written above.

CV Therapeutics, Inc.                          Andrew A. Wolff

By: /s/ Louis G. Lange                         /s/ Andrew A. Wolff
    ---------------------------------------    ---------------------------------
Name: Louis G. Lange
      -------------------------------------
Title: Chairman & Chief Executive Officer
      -------------------------------------

Exhibit A: Release (Individual Termination)
Exhibit B: Release (Group Termination)

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                                    Exhibit A

                                     RELEASE
                            (Individual Termination)

         Certain capitalized terms used in this Release are defined in the
Amended and Restated Executive Severance Benefits Agreement (the "Agreement")
which I have executed and of which this Release is a part.

         I hereby confirm my obligations under the Company's proprietary
information and inventions agreement.

         I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A general release does not extend
to claims which the creditor does not know or suspect to exist in his favor at
the time of executing the release, which if known by him must have materially
affected his settlement with the debtor." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

         Except as otherwise set forth in this Release, I hereby release, acquit
and forever discharge the Company, its parents and subsidiaries, and their
officers, directors, agents, servants, employees, shareholders, successors,
assigns and affiliates, of and from any and all claims, liabilities, demands,
causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and
unknown, suspected and unsuspected, disclosed and undisclosed (other than any
claim for indemnification I may have as a result of any third party action
against me based on my employment with the Company), arising out of or in any
way related to agreements, events, acts or conduct at any time prior to the date
I execute this Release, including, but not limited to: all such claims and
demands directly or indirectly arising out of or in any way connected with my
employment with the Company or the termination of that employment, including but
not limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the California Fair Employment and
Housing Act, as amended; tort law; contract law; statutory law; common law;
wrongful discharge; discrimination; fraud; defamation; emotional distress; and
breach of the implied covenant of good faith and fair dealing; provided,
however, that nothing in this paragraph shall be construed in any way to release
the Company from its obligation to indemnify me pursuant to the Company's
indemnification obligation pursuant to agreement or applicable law.

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         I acknowledge that I am knowingly and voluntarily waiving and releasing
any rights I may have under ADEA. I also acknowledge that the consideration
given under the Agreement for the waiver and release in the preceding paragraph
hereof is in addition to anything of value to which I was already entitled. I
further acknowledge that I have been advised by this writing, as required by the
ADEA, that: (A) my waiver and release do not apply to any rights or claims that
may arise on or after the date I execute this Release; (B) I have the right to
consult with an attorney prior to executing this Release; (C) I have twenty-one
(21) days to consider this Release (although I may choose to voluntarily execute
this Release earlier); (D) I have seven (7) days following the execution of this
Release by the parties to revoke the Release; and (E) this Release shall not be
effective until the date upon which the revocation period has expired, which
shall be the eighth day after this Release is executed by me.

                                          Andrew A. Wolff

                                          ______________________________________
                                          Date: ________________________________

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                                    Exhibit B

                                     RELEASE
                               (Group Termination)

         Certain capitalized terms used in this Release are defined in the
Amended and Restated Executive Severance Benefits Agreement (the "Agreement")
which I have executed and of which this Release is a part.

         I hereby confirm my obligations under the Company's proprietary
information and inventions agreement.

         I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A general release does not extend
to claims which the creditor does not know or suspect to exist in his favor at
the time of executing the release, which if known by him must have materially
affected his settlement with the debtor." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

         Except as otherwise set forth in this Release, I hereby release, acquit
and forever discharge the Company, its parents and subsidiaries, and their
officers, directors, agents, servants, employees, shareholders, successors,
assigns and affiliates, of and from any and all claims, liabilities, demands,
causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and
unknown, suspected and unsuspected, disclosed and undisclosed (other than any
claim for indemnification I may have as a result of any third party action
against me based on my employment with the Company), arising out of or in any
way related to agreements, events, acts or conduct at any time prior to the date
I execute this Release, including, but not limited to: all such claims and
demands directly or indirectly arising out of or in any way connected with my
employment with the Company or the termination of that employment, including but
not limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the California Fair Employment and
Housing Act, as amended; tort law; contract law; statutory law; common law;
wrongful discharge; discrimination; fraud; defamation; emotional distress; and
breach of the implied covenant of good faith and fair dealing; provided,
however, that nothing in this paragraph shall be construed in any way to release
the Company from its obligation to indemnify me pursuant to the Company's
indemnification obligation pursuant to agreement or applicable law.

         I acknowledge that I am knowingly and voluntarily waiving and releasing
any rights I may have under ADEA. I also acknowledge that the consideration
given under the Agreement

                                        1

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for the waiver and release in the preceding paragraph hereof is in addition to
anything of value to which I was already entitled. I further acknowledge that I
have been advised by this writing, as required by the ADEA, that: (A) my waiver
and release do not apply to any rights or claims that may arise on or after the
date I execute this Release; (B) I have the right to consult with an attorney
prior to executing this Release; (C) I have forty-five (45) days to consider
this Release (although I may choose to voluntarily execute this Release
earlier); (D) I have seven (7) days following the execution of this Release by
the parties to revoke the Release; (E) this Release shall not be effective until
the date upon which the revocation period has expired, which shall be the eighth
day after this Release is executed by me; and (F) I have received with this
Release a detailed list of the job titles and ages of all employees who were
terminated in this group termination and the ages of all employees of the
Company in the same job classification or organizational unit who were not
terminated.

                                          Andrew A. Wolff

                                          ______________________________________
                                          Date: ________________________________

                                        2<PAGE>

                                                                   EXHIBIT 10.61

                              CV Therapeutics, Inc.
          Change in Control Plan with Respect to Options and Severance
                         (and Summary Plan Description)

     This Change in Control Plan with Respect to Options and Severance (the
"Plan") sets forth the terms of severance benefits for certain employees in the
event of a Change in Control of CV Therapeutics, Inc. (together with any
successor to substantially all of its business, stock or assets, the "Company")
or the termination of employment with the Company under the circumstances
described below after a Change in Control.

     The Plan is an employee welfare benefit plan subject to the Employee
Retirement Income Security Act of 1974, as amended ("ERISA"). This Plan document
is also the summary plan description of the Plan. References in the Plan to
"You" or "Your" are references to an employee of the Company.

     1. General Eligibility. You shall only be eligible for benefits under this
Plan if, immediately prior to the effective date of a Change in Control, you are
a full-time employee of the Company; provided, however, that any employee who
holds a title of Vice President, Senior Vice President or Chief Executive
Officer as of such date shall not be eligible for benefits under this Plan, and
any employee who is a party to any individual severance agreement approved by
the board of directors of the Company as of such date shall not be eligible for
benefits under this Plan.

     2. Treatment of Options upon Change in Control. No later than five (5)
business days before the effective date of a Change in Control, your
then-outstanding Options shall, automatically and without further action by the
Company, become one hundred percent (100%) vested and exercisable.

     3. Enhanced Severance. Upon a Triggering Event following a Change in
Control, you shall receive the severance benefits set forth in subsections (a)
through (c) below:

           (a) Base Salary. You will receive, as severance, your base salary for
a period (the "Severance Period") equal to (i) three (3) months, plus, but only
if and to the extent applicable to you, (ii) an additional two (2) weeks for
each full year of your service as an employee of the Company through the date of
the Triggering Event; provided, however, that in no event shall such Severance
Period exceed twelve (12) months. Such severance amount shall be paid in cash in
a lump sum within thirty (30) days following the Triggering Event and shall be
subject to all required tax withholding. For purposes of determining your salary
severance benefits, your base salary will be equal to your base salary as in
effect during the last regularly scheduled payroll period immediately preceding
the Triggering Event.

           (b) Bonus. The Company shall pay you an amount equal to one hundred
and fifty percent (150%) of the annual bonus paid to you in the year immediately
preceding the effective date of the Change in Control. Such severance amount
shall be paid in cash in a lump sum within thirty (30) days following the
Triggering Event and shall be subject to all required tax withholding.

                                        1

<PAGE>

           (c) Health Benefits. Provided that you elect continued coverage under
the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended
("COBRA"), the Company shall pay the premiums of your group health insurance
coverage, including coverage for your eligible dependents, for the Severance
Period; provided, however, that the Company shall pay premiums for your eligible
dependents only for coverage for which those eligible dependents were enrolled
immediately prior to the Triggering Event. No premium payments will be made
following the effective date of your coverage by a health insurance plan of a
subsequent employer. For the balance of the period that you are entitled to
coverage under federal COBRA law, if any, you will be entitled to maintain such
coverage at your own expense.

     4. Release Prior To Payment Of Benefits. Upon the occurrence of a
Triggering Event, and prior to the payment of any benefits under this Plan, you
will be required to execute a release (the "Release") in the form attached
hereto and incorporated herein as Appendix A or Appendix B, as applicable. Such
Release shall specifically relate to all of your rights and claims in existence
at the time of such execution and shall confirm your obligations under the
Company's standard form of proprietary information and inventions agreement. It
is understood that, as specified in the applicable Release, you will have a
certain number of calendar days to consider whether to execute such Release, and
you may revoke such Release within seven (7) calendar days after execution. In
the event you do not execute such Release within the applicable period, or if
you revoke such Release within the subsequent seven (7) day period, no benefits
shall be payable under this Plan to you.

     5. Parachute Payments.

           (a) If any payment or benefit you would receive under this Plan, when
combined with any other payment or benefit you receive pursuant to the
termination of your employment with the Company ("Payment"), would (i)
constitute a "parachute payment" within the meaning of Section 280G of the
Internal Revenue Code of 1986, as amended (the "Code"), and (ii) but for this
sentence, be subject to the excise tax imposed by Section 4999 of the Code (the
"Excise Tax"), then such Payment shall be either (x) the full amount of such
Payment or (y) such lesser amount (with cash payments being reduced before stock
option compensation) as would result in no portion of the Payment being subject
to the Excise Tax, whichever of the foregoing amounts, taking into account the
applicable federal, state and local employment taxes, income taxes, and the
Excise Tax, results in your receipt, on an after-tax basis, of the greater
amount of the Payment notwithstanding that all or some portion of the Payment
may be subject to the Excise Tax.

           (b) All determinations required to be made under this Section 5,
including whether and to what extent the Payments shall be reduced and the
assumptions to be utilized in arriving at such determination, shall be made by
the nationally recognized certified public accounting firm used by the Company
immediately prior to the effective date of the Change in Control or, if such
firm declines to serve, such other nationally recognized certified public
accounting firm as may be designated by the Company (the "Accounting Firm"). The
Accounting Firm shall provide detailed supporting calculations both to you and
the Company at such time as is requested by the Company. All fees and expenses
of the Accounting Firm shall be borne solely by the Company. Any determination
by the Accounting Firm shall be binding upon you and the Company. For purposes
of making the calculations required by this Section 5,

                                        2

<PAGE>

the Accounting Firm may make reasonable assumptions and approximations
concerning applicable taxes and may rely on reasonable, good-faith
interpretations concerning the application of Sections 280G and 4999 of the
Code.

     6. Effective Date of Plan/Amendment. This Plan shall be effective as of
December 31, 2002. The Board of Directors of the Company shall have the power to
amend or terminate this Plan from time to time in its discretion and for any
reason (or no reason) prior to the occurrence of a Change in Control.

     7. Claims Procedures.

          (a) Normally, you do not need to present a formal claim to receive
benefits payable under this Plan.

          (b) If any person (the "Claimant") believes that benefits are being
denied improperly, that the Plan is not being operated properly, that
fiduciaries of the Plan have breached their duties, or that the Claimant's legal
rights are being violated with respect to the Plan, the Claimant must file a
formal claim, in writing, with the Plan Administrator. This requirement applies
to all claims that any Claimant has with respect to the Plan, including claims
against fiduciaries and former fiduciaries, except to the extent the Plan
Administrator determines, in its sole discretion, that it does not have the
power to grant all relief reasonably being sought by the Claimant.

          (c) A formal claim must be filed within ninety (90) days after the
date the Claimant first knew or should have known of the facts on which the
claim is based, unless the Plan Administrator in writing consents otherwise. The
Plan Administrator shall provide a Claimant, on request, with a copy of the
claims procedures established under subsection (d).

          (d) The Plan Administrator has adopted procedures for considering
claims (which are set forth in Appendix C), which it may amend from time to
time, as it sees fit. These procedures shall comply with all applicable legal
requirements. These procedures may provide that final and binding arbitration
shall be the ultimate means of contesting a denied claim (even if the Plan
Administrator or its delegates have failed to follow the prescribed procedures
with respect to the claim). The right to receive benefits under this Plan is
contingent on a Claimant using the prescribed claims procedures to resolve any
claim.

     8. Plan Administration.

          (a) The Plan shall be administered by the Compensation Committee of
the Company's Board of Directors and/or its delegate which shall be one or more
senior officers of the Company (the "Plan Administrator"). The Plan
Administrator is responsible for the general administration and management of
the Plan and shall have all powers and duties necessary to fulfill its
responsibilities, including, but not limited to, the discretion to interpret and
apply the Plan and to determine all questions relating to eligibility for
benefits. The Plan shall be interpreted in accordance with its terms and their
intended meanings. However, the Plan Administrator and all Plan fiduciaries
shall have the discretion to interpret or construe ambiguous, unclear, or
implied (but omitted) terms in any fashion they deem to be appropriate in their
sole discretion, and to make any findings of fact needed in the administration
of the Plan.

                                        3

<PAGE>

The validity of any such interpretation, construction, decision, or finding of
fact shall not be given de novo review if challenged in court, by arbitration,
or in any other forum, and shall be upheld unless clearly arbitrary or
capricious.

            (b) All actions taken and all determinations made in good faith by
the Plan Administrator or by Plan fiduciaries will be final and binding on all
persons claiming any interest in or under the Plan. To the extent the Plan
Administrator or any Plan fiduciary has been granted discretionary authority
under the Plan, the Plan Administrator's or Plan fiduciary's prior exercise of
such authority shall not obligate it to exercise its authority in a like fashion
thereafter.

            (c) If, due to errors in drafting, any Plan provision does not
accurately reflect its intended meaning, as demonstrated by consistent
interpretations or other evidence of intent, or as determined by the Plan
Administrator in its sole discretion, the provision shall be considered
ambiguous and shall be interpreted by the Plan Administrator and all Plan
fiduciaries in a fashion consistent with its intent, as determined in the sole
discretion of the Plan Administrator. The Plan Administrator shall amend the
Plan retroactively to cure any such ambiguity.

            (d) No Plan fiduciary shall have the authority to answer questions
about any pending or final business decision of the Company or any affiliate
that has not been officially announced, to make disclosures about such matters,
or even to discuss them, and no person shall rely on any unauthorized,
unofficial disclosure. Thus, before a decision is officially announced, no
fiduciary is authorized to tell any person, for example, that he or she will or
will not be laid off or that the Company will or will not offer exit incentives
in the future. Nothing in this subsection shall preclude any fiduciary from
fully participating in the consideration, making, or official announcement of
any business decision.

            (e) This Section may not be invoked by any person to require the
Plan to be interpreted in a manner inconsistent with its interpretation by the
Plan Administrator or other Plan fiduciaries.

     9. Superseding Plan. This Plan (i) shall be the only plan with respect to
which benefits may be provided to you as a result of any Triggering Event and
(ii) shall supersede any other plan previously adopted by the Company with
respect to severance benefits payable to you or the acceleration of your Options
as a result of a Change in Control. Any of your rights hereunder shall be in
addition to any rights you may otherwise have under benefit plans or agreements
of the Company (other than severance plans or agreements) to which you are a
party or in which you are a participant, including, but not limited to, any
Company-sponsored employee benefit plans and stock options plans.

     10. Limitation On Employee Rights. This Plan shall not give any employee
the right to be retained in the service of the Company, nor shall it interfere
with or restrict the right of the Company to discharge or retire the employee.

     11. No Third-Party Beneficiaries. This Plan shall not give any rights or
remedies to any person other than covered employees and the Company.

     12. Governing Law. This Plan is a welfare plan subject to ERISA and it
shall be interpreted, administered, and enforced in accordance with that law. To
the extent that state law

                                        4

<PAGE>

is applicable, the statutes and common law of the State of California, excluding
any that mandate the use of another jurisdiction's laws, shall apply.

     13. Miscellaneous. Where the context so indicates, the singular will
include the plural and vice versa. Titles are provided herein for convenience
only and are not to serve as a basis for interpretation or construction of the
Plan. Unless the context clearly indicates to the contrary, a reference to a
statute or document shall be construed as referring to any subsequently enacted,
adopted, or executed counterpart.

     14. Notice. For purposes of this Plan, notices and all other communications
provided for in this Plan shall be in writing and shall be deemed to have been
duly given when delivered or mailed by United States certified or registered
mail, return receipt requested, postage prepaid, addressed to the Company at its
primary office location and to an employee at such employee's last known address
as listed on the Company's records, provided that all notices to the Company
shall be directed to the attention of its Secretary, or to such other address as
either party may have furnished to the other in writing in accordance herewith,
except that notice of change of address shall be effective only upon receipt.

     15. Additional Information. As a participant in the Plan, you are entitled
to certain rights and protections under ERISA, as described in Appendix D.

     16. Definitions. For purposes of this Plan, the following terms shall have
the following meanings:

            (a) "Cause" means that, in the reasonable determination of the
Company, you:

                (i) have committed an act that materially injures the business
     of the Company;

                (ii)  have refused or failed to follow lawful and reasonable
     directions of the Board of Directors of the Company or the appropriate
     individual to whom you report;

                (iii) have willfully or habitually neglected your duties for the
     Company; or

                (iv)  have been convicted of a felony involving moral turpitude
     that is likely to inflict or has inflicted material injury on the business
     of the Company.

     Notwithstanding the foregoing, Cause shall not exist based on conduct
described in clause (ii) or clause (iii) unless the conduct described in such
clause has not been cured within fifteen (15) days following your receipt of
written notice from the Company specifying the particulars of the conduct
constituting Cause.

            (b) "Change in Control" means:

                (i)   a sale of substantially all of the assets of the Company;

                                        5

<PAGE>

                (ii)  a merger or consolidation in which the Company is not the
     surviving corporation (other than a merger or consolidation in which
     shareholders immediately before the merger or consolidation have,
     immediately after the merger or consolidation, equal or greater stock
     voting power);

                (iii) a reverse merger in which the Company is the surviving
     corporation but the shares of the Company's common stock outstanding
     immediately preceding the merger are converted by virtue of the merger into
     other property, whether in the form of securities, cash or otherwise (other
     than a reverse merger in which shareholders immediately before the merger
     have, immediately after the merger, greater stock voting power); or

                (iv) any transaction or series of related transactions in which
     in excess of 50% of the Company's voting power is transferred.

            (c) "Option" shall mean any option to purchase shares of Common
Stock of the Company outstanding at the time of a Change in Control and any
substitute option, if applicable, if such option has been assumed in a Change in
Control, regardless of whether such option has been granted as of the date
hereof under the Company's employee stock option plans, including, but not
limited to, the following plans:

                (i)   The CV Therapeutics, Inc. 2000 Equity Incentive Plan;

                (ii)  The CV Therapeutics, Inc. 2000 Non-Statutory Incentive
     Plan; and

                (iii) The CV Therapeutics, Inc. 1994 Equity Incentive Plan.

            (d) "Triggering Event" shall mean your employment is terminated by
the Company without Cause within thirteen (13) months following the effective
date of a Change in Control; provided, however, that if you are terminated by
the Company following the effective date of a Change in Control but accept
employment with the Company's successor or acquirer within ninety (90) days
after the effective date of the Change in Control, no Triggering Event shall
occur; and provided, further, however, that if you are terminated without Cause
by the successor or acquirer within the thirteen (13) months following the
effective date of the Change in Control, a Triggering Event shall occur. The
termination of your employment as a result of your death or disability will not
be deemed to be a termination without Cause for purposes of this definition.

                                        6

<PAGE>

                                   APPENDIX A

                                     RELEASE
                            (Individual Termination)

     Certain capitalized terms used in this Release are defined in the Change in
Control Plan with Respect to Options and Severance (the "Plan") which I have
executed and of which this Release is a part. I have been offered the
opportunity to receive the severance benefits described in Section 3 of the Plan
from the Company to which I otherwise would not be entitled by executing the
general release of claims set forth in this Release.

     I hereby confirm my obligations under the Company's proprietary information
and inventions agreement.

     I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A general release does not extend
to claims which the creditor does not know or suspect to exist in his favor at
the time of executing the release, which if known by him must have materially
affected his settlement with the debtor." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

     Except as otherwise set forth in this Release, I hereby release, acquit and
forever discharge the Company, its parents and subsidiaries, and their officers,
directors, agents, servants, employees, shareholders, successors, assigns and
affiliates, of and from any and all claims, liabilities, demands, causes of
action, costs, expenses, attorneys fees, damages, indemnities and obligations of
every kind and nature, in law, equity, or otherwise, known and unknown,
suspected and unsuspected, disclosed and undisclosed (other than any claim for
indemnification I may have as a result of any third party action against me
based on my employment with the Company), arising out of or in any way related
to agreements, events, acts or conduct at any time prior to the date I execute
this Release, including, but not limited to: all such claims and demands
directly or indirectly arising out of or in any way connected with my employment
with the Company or the termination of that employment, including but not
limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the California Fair Employment and
Housing Act, as amended; tort law; contract law; statutory law; common law;
wrongful discharge; discrimination; fraud; defamation; emotional distress; and
breach of the implied covenant of good faith and fair dealing.

                                        7

<PAGE>

                       FOR EMPLOYEES AGE 40 OR OLDER ONLY:

     I acknowledge that I am knowingly and voluntarily waiving and releasing any
rights I may have under ADEA. I also acknowledge that the consideration given
under the Plan for the waiver and release in the preceding paragraph hereof is
in addition to anything of value to which I was already entitled. I further
acknowledge that I have been advised by this writing, as required by the ADEA,
that: (A) my waiver and release do not apply to any rights or claims that may
arise on or after the date I execute this Release; (B) I have the right to
consult with an attorney prior to executing this Release; (C) I have twenty-one
(21) days to consider this Release (although I may choose to voluntarily execute
this Release earlier); (D) I have seven (7) days following the execution of this
Release by the parties to revoke the Release; and (E) this Release shall not be
effective until the date upon which the revocation period has expired, which
shall be the eighth day after this Release is executed by me.

                                              [Name of Employee]

                                              __________________________________

                                              Date:_____________________________

                                        8

<PAGE>

                                   APPENDIX B

                                     RELEASE
                               (Group Termination)

     Certain capitalized terms used in this Release are defined in the Change in
Control Plan with Respect to Options and Severance (the "Plan") which I have
executed and of which this Release is a part. I have been offered the
opportunity to receive the severance benefits described in Section 3 of the Plan
from the Company to which I otherwise would not be entitled by executing the
general release of claims set forth in this Release.

     I hereby confirm my obligations under the Company's proprietary information
and inventions agreement.

     I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A general release does not extend
to claims which the creditor does not know or suspect to exist in his favor at
the time of executing the release, which if known by him must have materially
affected his settlement with the debtor." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

     Except as otherwise set forth in this Release, I hereby release, acquit and
forever discharge the Company, its parents and subsidiaries, and their officers,
directors, agents, servants, employees, shareholders, successors, assigns and
affiliates, of and from any and all claims, liabilities, demands, causes of
action, costs, expenses, attorneys fees, damages, indemnities and obligations of
every kind and nature, in law, equity, or otherwise, known and unknown,
suspected and unsuspected, disclosed and undisclosed (other than any claim for
indemnification I may have as a result of any third party action against me
based on my employment with the Company), arising out of or in any way related
to agreements, events, acts or conduct at any time prior to the date I execute
this Release, including, but not limited to: all such claims and demands
directly or indirectly arising out of or in any way connected with my employment
with the Company or the termination of that employment, including but not
limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the California Fair Employment and
Housing Act, as amended; tort law; contract law; statutory law; common law;
wrongful discharge; discrimination; fraud; defamation; emotional distress; and
breach of the implied covenant of good faith and fair dealing.

<PAGE>

     The attachment to this Release includes a listing of the ages and job
titles of all employees of the Company who are eligible to receive the severance
benefits described in the Plan by signing a Release constituting a general
release of all claims.

                       FOR EMPLOYEES AGE 40 OR OLDER ONLY:

     I acknowledge that I am knowingly and voluntarily waiving and releasing any
rights I may have under ADEA. I also acknowledge that the consideration given
under the Plan for the waiver and release in the preceding paragraph hereof is
in addition to anything of value to which I was already entitled. I further
acknowledge that I have been advised by this writing, as required by the ADEA,
that: (A) my waiver and release do not apply to any rights or claims that may
arise on or after the date I execute this Release; (B) I have the right to
consult with an attorney prior to executing this Release; (C) I have forty-five
(45) days to consider this Release (although I may choose to voluntarily execute
this Release earlier); (D) I have seven (7) days following the execution of this
Release by the parties to revoke the Release; (E) this Release shall not be
effective until the date upon which the revocation period has expired, which
shall be the eighth day after this Release is executed by me; and (F) I have
received with this Release a detailed list of the job titles and ages of all
employees who were terminated in this group termination and the ages of all
employees of the Company in the same job classification or organizational unit
who were not terminated.

                                                     [Name of Employee]

                                                     ___________________________

                                                     Date:______________________

                                       10

<PAGE>

                              ATTACHMENT TO RELEASE

     The following information is provided to comply with the Older Workers
Benefit Protection Act. Capitalized terms used herein but not defined shall have
the meanings given them in the General Release to which this Attachment is
attached. Attached are the ages of all employees of CV Therapeutics, Inc. (the
"Company") who are eligible to receive the severance benefits described in the
Change in Control Plan with Respect to Options and Severance (the "Plan") by
signing a Release constituting a general release of all claims:

     (1)  The decisional unit is the Company.

     (2)  The attachment includes a listing of the ages and job titles of all
          employees of the Company who are eligible to receive the severance
          benefits described in the Plan by signing a Release constituting a
          general release of all claims.

                                       11

<PAGE>

                     JOB CLASSIFICATION AND AGE OF EMPLOYEES
                         ELIGIBLE FOR SEVERANCE BENEFITS

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          Job Title                                            Age
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<PAGE>

                                   APPENDIX C

                           DETAILED CLAIMS PROCEDURES

     1. Claims Procedure.

        (a) Initial Claims. All claims shall be presented to the Plan
Administrator in writing. Within ninety (90) days after receiving a claim, a
claims official appointed by the Plan Administrator shall consider the claim and
issue his or her determination thereon in writing. The claims official may
extend the determination period for up to an additional ninety (90) days by
giving the Claimant written notice. The initial claim determination period can
be extended further with the consent of the Claimant. Any claims that the
Claimant does not pursue in good faith through the initial claims stage shall be
treated as having been irrevocably waived.

        (b) Claims Decisions. If the claim is granted, the benefits or relief
the Claimant seeks shall be provided. If the claim is wholly or partially
denied, the claims official shall, within ninety (90) days (or a longer period,
as described above), provide the Claimant with written notice of the denial,
setting forth, in a manner calculated to be understood by the Claimant: (i) the
specific reason or reasons for the denial; (ii) specific references to the
provisions on which the denial is based; (iii) a description of any additional
material or information necessary for the Claimant to perfect the claim,
together with an explanation of why the material or information is necessary;
and (iv) appropriate information as to the steps to be taken if the claimant
wishes to submit his or her claim for review, including the time limits
applicable to such procedures, and a statement of the claimant's right to bring
a civil action under Section 502(a) of ERISA following an adverse decision upon
review. If the Claimant can establish that the claims official has failed to
respond to the claim in a timely manner, the Claimant may treat the claim as
having been denied by the claims official.

        (c) Appeals of Denied Claims. Each Claimant shall have the opportunity
to appeal the claims official's denial of a claim in writing to an appeals
official appointed by the Plan Administrator (which may be a person, committee,
or other entity). A Claimant must appeal a denied claim within sixty (60) days
after receipt of written notice of denial of the claim, or within sixty (60)
days after it was due if the Claimant did not receive it by its due date. The
Claimant (or his or her duly authorized representative) may review pertinent
documents in connection with the appeals proceeding and may present issues,
comments and documents in writing relating to the claim. The review shall take
into account all comments, documents, records and other information submitted by
the Claimant relating to the claim, without regard to whether such information
was submitted or considered in the initial benefit claim determination. Any
claims that the Claimant does not pursue in good faith through the appeals
stage, such as by failing to file a timely appeal request, shall be treated as
having been irrevocably waived.

        (d) Appeals Decisions. The decision by the appeals official shall be
made not later than sixty (60) days after the written appeal is received by the
Plan Administrator, unless special circumstances require an extension of time,
in which case a decision shall be rendered as soon as possible, but not later
than one hundred twenty (120) days after the appeal was filed, unless the
Claimant agrees to a further extension of time. The appeal decision shall be in
writing, shall be set forth in a manner calculated to be understood by the
Claimant, and shall

                                        2

<PAGE>

include specific reasons for the decision, specific references to the provisions
on which the decision is based, if applicable, a statement that the claimant is
entitled to receive upon request and free of charge reasonable access to and
copies of all documents, records and other information relevant to the
claimant's claim for benefits, as well as a statement of the claimant's right to
bring an action under Section 502(a) of ERISA. If a Claimant does not receive
the appeal decision by the date it is due, the Claimant may deem his or her
appeal to have been denied.

        (e) Procedures. The Plan Administrator shall adopt procedures by which
initial claims shall be considered and appeals shall be resolved; different
procedures may be established for different claims. All procedures shall be
designed to afford a Claimant full and fair consideration of his or her claim.

                                        3

<PAGE>

                                   APPENDIX D

                             ADDITIONAL INFORMATION

                               RIGHTS UNDER ERISA

     As a participant in the Plan, you are entitled to certain rights and
protections under ERISA. ERISA provides that all Plan participants will be
entitled to:

Receive Information About Your Plan and Benefits

     1. Examine, without charge, at the Plan Administrator's office and at
certain Company offices, all Plan documents including collective bargaining
agreements, if any, and copies of all documents filed by the Plan with the U.S.
Department of Labor, and available at the Public Disclosure Room of the Pension
and Welfare Benefit Administration, such as annual reports and Plan
descriptions.

     2. Obtain, upon written request to the Plan Administrator, copies of
documents governing the operation of the Plan, including collective bargaining
agreements and copies of the latest annual report (Form 5500 Series) and updated
summary plan description. The Plan Administrator may make a reasonable charge
for the copies.

     3. Obtain upon written request to the Plan Administrator information as to
whether a particular employer or employer organization is a sponsor of the Plan
and the address of any employer or employer organization that is a plan sponsor.
Your beneficiaries also have a right to obtain this information upon written
request to the Plan Administrator.

     4. Receive a summary of the Plan's annual financial report. The Plan
Administrator is required by law to furnish each participant with a copy of this
summary annual report.

     5. Receive a written explanation of why a claim for benefits has been
denied, in whole or in part, and a review and reconsideration of the claim.

     6. Continue health care coverage for yourself, spouse or dependent if there
is a loss of coverage as a result of a qualifying event. You or your dependents
may have to pay for such coverage. Review this Plan and summary plan description
on the rules governing your COBRA continuation coverage rights.

Prudent Actions by Plan Fiduciaries

     In addition to creating rights for Plan participants, ERISA imposes duties
upon the people who are responsible for the operation of the employee benefit
plan. The people who operate your Plan, called "fiduciaries" of the Plan, have a
duty to do so prudently and in the interest of you and other Plan participants
and beneficiaries. No one, including the Company, your union, or any other
person, may fire you or otherwise discriminate against you in any way to prevent
your from obtaining a welfare benefit or exercising your right under ERISA.
However, this rule neither guarantees continued employment, nor affects the
Company's right to terminate your employment for other reasons.

<PAGE>

Enforce Your Rights

     If your claim for a welfare benefit is denied or ignored, in whole or in
part, you have a right to know why this was done, to obtain copies of documents
relating to the decision without charge, and to appeal any denial, all within
certain time schedules.

     Under ERISA, there are steps you can take to enforce the above rights. For
instance, if you request a copy of plan documents or the latest annual report
from the Plan and do not receive them within thirty (30) days, you may file suit
in a Federal court. In such a case, the court may require the Plan Administrator
to provide the materials and pay you up to $110 a day until you receive the
materials, unless the materials were not sent because of reasons beyond the
control of the Plan Administrator. If you have a claim for benefits which is
denied or ignored, in whole or in part, you may file suit in a state or Federal
court. In addition, if you disagree with the Plan's decision or lack thereof
concerning the qualified status of a domestic relations order or a medical child
support order, you may file suit in Federal court. If it should happen that Plan
fiduciaries misuse the Plan's money, or if you are discriminated against for
asserting your rights, you may seek assistance from the U.S. Department of
Labor, or you may file suit in a federal court. The court will decide who should
pay court costs and legal fees. If you are successful, the court may order the
person you have sued to pay these costs and fees. If you lose, the court may
order you to pay these costs and fees, for example, if it finds your claim is
frivolous.

Assistance with Your Questions

     If you have any questions about your Plan, you should contact the Plan
Administrator. If you should have any questions about this statement or about
your rights under ERISA, or if you need assistance in obtaining documents from
the Plan Administrator, you should contact the nearest office of the Pension and
Welfare Benefits Administration, U. S. Department of Labor, listed in your
telephone directory or the Division of Technical Assistance and Inquires,
Pension and Welfare Benefits Administration, U. S. Department of Labor, 200
Constitution Avenue N. W., Washington, D. C. 20210. You may also obtain certain
publications about your rights and responsibilities under ERISA by calling the
publications hotline of the Pension and Welfare Benefits Administration.

                                        2

<PAGE>

                           ADMINISTRATIVE INFORMATION
<TABLE>
<S>                                   <C>
Name of Plan:                         The CV Therapeutics, Inc. Change in Control Plan with
                                      respect to Options and Severance

Plan Administrator:                   Compensation Committee of the Board of Directors
                                      CV Therapeutics, Inc.
                                      3172 Porter Drive
                                      Palo Alto, CA 94394
                                      Tel: 650-384-8500
                                      Fax: 650-858-0390

Type of Administration:               Self-Administered

Type of Plan:                         Severance Pay Employee Welfare Benefit Plan

Employer Identification Number:       43-1570294

Direct Questions Regarding the        General Counsel
Plan to:                              CV Therapeutics, Inc.
                                      3172 Porter Drive
                                      Palo Alto, CA 94394
                                      Tel: 650-384-8500
                                      Fax: 650-858-0390

Agent for Service of Legal            General Counsel
Process:                              CV Therapeutics, Inc.
                                      3172 Porter Drive
                                      Palo Alto, CA 94394
                                      Tel: 650-384-8500
                                      Fax: 650-858-0388

                                      Service of Legal Process may also be made upon the Plan
                                      Administrator

Plan Year:                            Calendar Year

Plan Number:                          505
</TABLE>

                                        3

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