Document:

EX-4.1

 Exhibit 4.1 

TARGACEPT, INC., 
 as
Issuer, 
 and 
 AMERICAN
STOCK TRANSFER & TRUST COMPANY, LLC, 
 Trustee 

Indenture 
 Dated as of
August 19, 2015 
 Providing for the Issuance 

Of 
 Redeemable Convertible Notes
due 2018 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
			
	 ARTICLE I
	 		  			
			
		 	 DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION
	  	 	2	 
			
	 Section 1.01
	 	Definitions.	  	 	2	 
			
	 Section 1.02
	 	Compliance Certificates and Opinions.	  	 	8	 
			
	 Section 1.03
	 	Form of Documents Delivered to Trustee.	  	 	8	 
			
	 Section 1.04
	 	Acts of Holders.	  	 	9	 
			
	 Section 1.05
	 	Notices, Etc., to Trustee and the Company.	  	 	10	 
			
	 Section 1.06
	 	Notice to Holders; Waiver.	  	 	10	 
			
	 Section 1.07
	 	Effect of Headings and Table of Contents.	  	 	11	 
			
	 Section 1.08
	 	Successors and Assigns.	  	 	11	 
			
	 Section 1.09
	 	Separability Clause.	  	 	11	 
			
	 Section 1.10
	 	Benefits of Indenture.	  	 	11	 
			
	 Section 1.11
	 	No Security Interests Created	  	 	11	 
			
	 Section 1.12
	 	Governing Law.	  	 	12	 
			
	 Section 1.13
	 	Legal Holidays.	  	 	12	 
			
	 Section 1.14
	 	Submission to Jurisdiction.	  	 	12	 
			
	 Section 1.15
	 	Conflict with Trust Indenture Act.	  	 	12	 
			
	 Section 1.16
	 	Counterparts.	  	 	12	 
			
	 ARTICLE II
	 		  			
			
		 	 SECURITIES FORMS
	  	 	13	  
			
	 Section 2.01
	 	Form and Dating.	  	 	13	  
			
	 Section 2.02
	 	Form of Trustee’s Certificate of Authentication.	  	 	13	 
			
	 Section 2.03
	 	Global Security in General.	  	 	13	 
			
	 Section 2.04
	 	Legends.	  	 	13	 
			
	 Section 2.05
	 	Definitive Securities.	  	 	14	 
			
	 ARTICLE III
	 		  			
			
		 	 THE SECURITIES
	  	 	14	 

  
 i 

							
	 	 	 	  	Page	 
			
	 Section 3.01
	 	Title; Amount and General Information.	  	 	14	 
			
	 Section 3.02
	 	Denominations.	  	 	15	  
			
	 Section 3.03
	 	Execution, Authentication, Delivery and Dating.	  	 	15	 
			
	 Section 3.04
	 	Temporary Securities.	  	 	15	 
			
	 Section 3.05
	 	Registration, Transfer and Exchange.	  	 	16	 
			
	 Section 3.06
	 	Mutilated, Destroyed, Lost and Stolen Securities.	  	 	17	 
			
	 Section 3.07
	 	Persons Deemed Owners.	  	 	18	 
			
	 Section 3.08
	 	Book-Entry Provisions for the Global Securities.	  	 	18	 
			
	 Section 3.09
	 	Cancellation.	  	 	20	 
			
	 Section 3.10
	 	CUSIP Numbers.	  	 	20	 
			
	 Section 3.11
	 	Withholding.	  	 	21	 
			
	 ARTICLE IV
	 		  			
			
		 	 REMEDIES
	  	 	21	 
			
	 Section 4.01
	 	Events of Default.	  	 	21	 
			
	 Section 4.02
	 	Acceleration of Maturity.	  	 	22	 
			
	 Section 4.03
	 	Collection of Indebtedness and Suits for Enforcement by Trustee.	  	 	23	 
			
	 Section 4.04
	 	Trustee May File Proofs of Claim.	  	 	24	 
			
	 Section 4.05
	 	Trustee May Enforce Claims Without Possession of Securities.	  	 	24	 
			
	 Section 4.06
	 	Application of Money Collected.	  	 	24	 
			
	 Section 4.07
	 	Limitation on Suits.	  	 	25	 
			
	 Section 4.08
	 	Unconditional Right of Holders to Receive Payment, to Redeem and to Convert.	  	 	25	 
			
	 Section 4.09
	 	Restoration of Rights and Remedies.	  	 	26	 
			
	 Section 4.10
	 	Rights and Remedies Cumulative.	  	 	26	 
			
	 Section 4.11
	 	Delay or Omission Not Waiver.	  	 	26	 
			
	 Section 4.12
	 	Control by Holders of Securities.	  	 	26	 
			
	 Section 4.13
	 	Waiver of Past Defaults.	  	 	27	 
			
	 Section 4.14
	 	Waiver of Stay or Extension Laws.	  	 	27	 
			
	 Section 4.15
	 	Undertaking for Costs.	  	 	27	 
		
	ARTICLE V	  			
			
		 	 THE TRUSTEE
	  	 	27	 
			
	Section 5.01	 	Duties of Trustee and Notice of Defaults.	  	 	27	 
			
	Section 5.02	 	Certain Rights of Trustee.	  	 	28	 

  
 ii 

							
	 	 	 	  	Page	 
			
	 Section 5.03
	 	Not Responsible for Recitals or Issuance of Securities.	  	 	30	 
			
	 Section 5.04
	 	May Hold Securities.	  	 	30	 
			
	 Section 5.05
	 	Compensation and Reimbursement and Indemnification of Trustee.	  	 	30	 
			
	 Section 5.06
	 	Corporate Trustee Required; Eligibility.	  	 	31	 
			
	 Section 5.07
	 	Disqualification; Conflicting Interests.	  	 	31	 
			
	 Section 5.08
	 	Resignation and Removal; Appointment of Successor.	  	 	32	 
			
	 Section 5.09
	 	Acceptance of Appointment by Successor.	  	 	33	 
			
	 Section 5.10
	 	Merger, Conversion, Consolidation or Succession to Business.	  	 	33	 
			
	 Section 5.11
	 	Appointment of Authenticating Agent.	  	 	34	 
		
	ARTICLE VI	 		
			
		 	 HOLDERS’ LISTS AND REPORTS BY TRUSTEE AND COMPANY
	  	 	35	 
			
	 Section 6.01
	 	Disclosure of Names and Addresses of Holders.	  	 	35	 
			
	 Section 6.02
	 	Preservation of Information; Communications to Holders.	  	 	36	 
			
	 Section 6.03
	 	Reports by Trustee.	  	 	36	 
			
	 Section 6.04
	 	Reports by Company.	  	 	36	 
			
	 Section 6.05
	 	Preferential Collection of Claims Against Company.	  	 	37	 
		
	ARTICLE VII	 		
			
		 	 CONSOLIDATION, MERGER, CONVEYANCE OR TRANSFER
	  	 	37	 
			
	 Section 7.01
	 	Company May Consolidate, Etc., Only on Certain Terms.	  	 	37	 
			
	 Section 7.02
	 	Successor Person Substituted.	  	 	38	 
		
	ARTICLE VIII	 		
			
		 	 SUPPLEMENTAL INDENTURES
	  	 	38	 
			
	 Section 8.01
	 	Supplemental Indentures Without Consent of Holders.	  	 	38	 
			
	 Section 8.02
	 	Supplemental Indentures with Consent of Holders.	  	 	39	 
			
	 Section 8.03
	 	Execution of Supplemental Indentures.	  	 	40	 
			
	 Section 8.04
	 	Effect of Supplemental Indentures.	  	 	40	 
			
	 Section 8.05
	 	Conformity with Trust Indenture Act.	  	 	40	 
			
	 Section 8.06
	 	Reference in Securities to Supplemental Indentures.	  	 	40	 
			
	ARTICLE IX	 		  			
			
		 	 COVENANTS
	  	 	41	  

  
 iii 

							
	 	 	 	  	Page	 
			
	 Section 9.01
	 	Payment of Principal.	  	 	41	 
			
	 Section 9.02
	 	Maintenance of Office or Agency.	  	 	41	 
			
	 Section 9.03
	 	Money for Securities Payments to Be Held in Escrow.	  	 	41	 
			
	 Section 9.04
	 	Statement as to Compliance.	  	 	42	 
			
	 Section 9.05
	 	Corporate Existence.	  	 	42	 
			
	 Section 9.06
	 	Reports to Holders.	  	 	42	 
			
	 Section 9.07
	 	Liens.	  	 	42	 
			
	 Section 9.08
	 	Escrow Agreement.	  	 	42	 
			
	 Section 9.09
	 	Treatment of Escrow Funds.	  	 	43	 
			
	 ARTICLE X
	 		  			
			
		 	 CONVERSION
	  	 	43	 
			
	 Section 10.01
	 	Conversion of Securities.	  	 	43	 
			
	 Section 10.02
	 	Adjustments to Conversion Rate.	  	 	44	 
			
	 Section 10.03
	 	Effect of Reclassification, Consolidation, Merger or Sale.	  	 	51	 
			
	 Section 10.04
	 	Responsibility of Trustee.	  	 	52	 
			
	 Section 10.05
	 	Notice to Holders Prior to Certain Actions.	  	 	53	 
			
	 Section 10.06
	 	Stockholder Rights Plan.	  	 	54	 
			
	 ARTICLE XI
	 		  			
			
		 	 REDEMPTION
	  	 	54	 
			
	 Section 11.01
	 	Redemptions.	  	 	54	 

  
 iv 

 INDENTURE, dated as of August 19, 2015, by and among TARGACEPT, INC., a Delaware corporation
(hereinafter called the “Company”), having its principal office at 100 North Main Street, Suite 1510, Winston-Salem, North Carolina 27101, and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, a New York limited liability trust
company, as Trustee (hereinafter called the “Trustee”), having its Corporate Trust Office at 6201 15th Avenue, Brooklyn, NY 11219. 

RECITALS OF THE COMPANY 

WHEREAS, the Company, in partial satisfaction of the dividend (the “Dividend”) declared by the Company payable to holders of the
shares of the Company’s common stock, par value $0.0001 per share, as of the Dividend Record Date, shall issue to the Record Holders Redeemable Convertible Notes due 2018 (hereinafter called the “Securities”) evidencing the
Company’s indebtedness, which may be convertible, in a minimum amount of $50,000 per conversion (or such Holder’s (as defined herein) entire principal amount of Securities held, if less), into shares of Common Stock (as defined herein) or
redeemed for cash at any time, and has duly authorized the execution and delivery of this Indenture (as defined herein) to provide for the issuance of the Securities at the time of the execution of this Indenture, to mature at such time and to have
such other provisions as shall be fixed as hereinafter provided; 
 WHEREAS, contemporaneously with the payment of the Dividend, the Company
shall fund, in cash, the principal amount of the Securities (the “Escrow Funds”) into a segregated account to be held by the Escrow Agent (as defined herein); 

WHEREAS, following the payment of the Dividend and the funding by the Company of the Escrow Funds, TALOS MERGER SUB, INC., a Delaware
corporation and a wholly-owned subsidiary of the Company (“Merger Sub”) shall be merged (the “Merger”) with and into CATALYST BIOSCIENCES, INC., a Delaware corporation
(“CBI”), with CBI surviving the Merger as a wholly-owned subsidiary of the Company, in accordance with that certain Agreement and Plan of Merger, dated as of March 5, 2015 by and among the Company, Merger Sub and CBI; 

WHEREAS, this Indenture is subject to the provisions of the Trust Indenture Act (as defined herein), that are required to be part of this
Indenture and shall, to the extent applicable, be governed by such provisions; and 
 WHEREAS, all things necessary to make this Indenture a
valid and legally binding agreement of the Company, in accordance with its terms, have been done; 
 NOW, THEREFORE, THIS INDENTURE
WITNESSETH: 
 For and in consideration of the premises and the receipt of the Securities by the Holders (as defined herein) thereof, it is
mutually covenanted and agreed, for the equal and proportionate benefit of all Holders, as follows: 

  
 1 

 ARTICLE I 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 

Section 1.01 Definitions. 
 For all
purposes of this Indenture, except as otherwise expressly provided or unless the context otherwise requires: 
 (1) the terms defined in
this Article One have the meanings assigned to them in this Article One, and include the plural as well as the singular; 
 (2) all other
terms used herein which are defined in the Trust Indenture Act, either directly or by reference therein, have the meanings assigned to them therein; 

(3) all accounting terms not otherwise defined herein have the meanings assigned to them in accordance with generally accepted accounting
principles in the United States of America; and 
 (4) the words “herein”, “hereof” and “hereunder” and other
words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other subdivision. 

“Act,” when used with respect to any Holder of a Security, has the meaning specified in Section 1.04. 

“Agent Members” means members of, or participants in, the Depositary. 

“Affiliate” of any specified Person means any other Person directly or indirectly controlling or controlled by or under
direct or indirect common control with such specified Person. For the purposes of this definition, “control” when used with respect to any specified Person means the power to direct the management and policies of such Person, directly or
indirectly, whether through the ownership of voting securities, by contract or otherwise, and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 

“Authenticating Agent” means any authenticating agent appointed by the Trustee pursuant to Section 5.11 to act on behalf
of the Trustee to authenticate Securities. 
 “Bankruptcy Law” means Title 11 of the U.S. Code or any applicable federal or
state bankruptcy, insolvency, reorganization or other similar law or analogous foreign law for the relief of debtors. 
 “Beneficial
Owner” means any Person who is considered a beneficial owner of a security in accordance with Rule 13d-3 under the Exchange Act. 

“Board of Directors” means the board of directors of the Company or any committee thereof duly authorized to act hereunder.

 “Board Resolution” means a copy of one or more resolutions certified by the Secretary or an Assistant Secretary of the
Company to have been duly adopted by the Board of Directors and to be in full force and effect on the date of such certification, and delivered to the Trustee. 

  
 2 

 “Business Day” means each Monday, Tuesday, Wednesday, Thursday and Friday which
is not a day on which banking institutions in The City of New York are authorized or obligated by law, regulation or executive order to close. 

“Capital Stock” means any and all shares, interests, rights to purchase, warrants, options, participations or other
equivalents of or interests in (however designated) stock issued by the Company. 
 “Close of Business” means 5:00 p.m.,
Eastern Time, on any Business Day. 
 “Closing Price” means, in the case of the Common Stock, the average of the price per
share of the final trade of the Common Stock on the applicable Trading Day on the Principal Securities Exchanges, such average to be weighted based on the percentage of trading activity conducted on such Trading Day on each of the Principal
Securities Exchanges and, in the case of other securities, the price per unit of the final trade of such security on the applicable Trading Day on the principal national securities exchange on which such security is listed or admitted to trading.

 “Commission” means the Securities and Exchange Commission. 

“Common Stock” means the shares of the class designated as common stock of the Company at the date of this Indenture as such
stock may be reconstituted from time to time. Subject to the provisions of Section 10.03, shares issuable upon conversion of Securities shall include only shares of Common Stock or shares of any class or classes of common stock resulting from
any reclassification or reclassifications thereof; provided, however, that if at any time there shall be more than one such resulting class, the shares so issuable on conversion of Securities shall include shares of all such classes, and the
shares of each such class then so issuable shall be substantially in the proportion which the total number of shares of such class resulting from all such reclassifications bears to the total number of shares of all such classes resulting from all
such reclassifications. 
 “Company” has the meaning specified in the first paragraph of this Indenture. 

“Company Request” and “Company Order” mean, respectively, a written request or order, as the case may be,
signed in the name of the Company by any one of its Chairman of the Board of Directors, its Chief Executive Officer, its President, its Chief Financial Officer or a Vice President and by any one of its Secretary or its Controller, and delivered to
the Trustee. 
 “Conversion Agent” means the office or agency appointed by the Company where Securities may be presented
for conversion. The Conversion Agent appointed by the Company shall initially be the Trustee. 
 “Conversion Date” has the
meaning specified in Section 10.01. 
 “Conversion Rate” means a stated price to be computed as the quotient of 1 and
$1.313, subject to adjustment as set forth in Section 10.02. 

  
 3 

 “Corporate Trust Office” means the office of the Trustee at which, at any
particular time, its corporate trust business shall be principally administered, which office at the date hereof is located at 6201 15th Avenue, Brooklyn, NY 11219. 

“Corporation” includes corporations, limited liability companies, associations, companies and business trusts. 

“Current Market Price” means the average Closing Price for the 10 consecutive Business Days immediately preceding, but not
including, the date as of which the Current Market Price is to be determined. 
 “CUSIP” has the meaning specified in
Section 3.10. 
 “Custodian” means any custodian, receiver, trustee, assignee, liquidator, sequestrator or other
similar official under any Bankruptcy Law. 
 “Default” means any event which is, or after notice or passage of time or
both would be, an Event of Default. 
 “Definitive Securities” means any certificated Securities that are not Global
Securities. 
 “Depositary” means the Person designated, which shall originally be the Depository Trust Company or any
nominee thereof, as depositary of the Global Securities by the Company until a successor Depositary shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Depositary” shall mean the Person
who is then depositary for the Global Securities. 
 “Distributed Property” has the meaning specified in
Section 10.02. 
 “Dividend Record Date” means August 14, 2015. 

“Dollar” or “$” means a dollar or other equivalent unit in such coin or currency of the United States of
America as at the time shall be legal tender for the payment of public and private debts. 
 “Event of Default” has the
meaning specified in Section 4.01. 
 “Escrow Agent” means that certain Escrow Agent appointed by the Company pursuant
to the Escrow Agreement. The Escrow Agent appointed by the company shall initially be Delaware Trust Company. 
 “Escrow
Agreement” means the Escrow Agreement, dated as of the date hereof, between the Company, the Escrow Agent and the Trustee, as such agreement may be amended, supplemented or modified from time to time in accordance with its terms. 

“Escrow Funds” has the meaning specified in the Recitals. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

  
 4 

 “Expiration Date” has the meaning specified in Section 10.02. 

“Global Securities” means the certificated Securities in global form, registered in the name of the Depositary. 

“Holder” means the Person in whose name a Security is registered in the Security Register. 

“Indenture” means this instrument as originally executed or as it may from time to time be supplemented or amended by one or
more indentures supplemental hereto entered into pursuant to the applicable provisions hereof. 
 “Issuance Date” means
August 19, 2015. 
 “Lien” means, with respect to any asset, any mortgage, lien, pledge, charge, security interest or
encumbrance of any kind with respect to such asset. 
 “Notice of Default” has the meaning specified in Section 5.01.

 “Officers’ Certificate” means a certificate signed by any of the Company’s Chairman of the Board of Directors,
its Chief Executive Officer, its President, its Chief Financial Officer or a Vice President and by any one of its Secretary or its Controller, and delivered to the Trustee. 

“Open of Business” means 9:00 a.m., Eastern Time, on any Business Day. “Opinion of Counsel” means a written
opinion of counsel, who may be counsel for the Company or who may be an employee of or other counsel for the Company, and who shall be reasonably acceptable to the Trustee. 

“Outstanding”, when used with respect to the Securities, means, as of the date of determination, all Securities, theretofore
authenticated and delivered under this Indenture, except: 
 (i) Securities theretofore cancelled by the Trustee or the Security Registrar
or delivered to, or accepted by, the Trustee or the Security Registrar for cancellation; 
 (ii) Securities which have been paid pursuant to
Section 3.06 or in exchange for or in lieu of which other Securities have been authenticated and delivered pursuant to this Indenture; 

(iii) Securities converted into shares of Common Stock as contemplated herein; and 

(iv) Securities redeemed for cash as contemplated herein; 

provided, however, that in determining whether the Holders of the requisite principal amount of the Outstanding Securities have given any request,
demand, authorization, direction, notice, consent or waiver hereunder or are present at a meeting of Holders for quorum purposes, and for the purpose of making the calculations required by Section 313 of the Trust Indenture Act, Securities
owned by the Company or any other obligor upon the Securities or any Affiliate of the Company or of such other obligor shall be disregarded and deemed not to be Outstanding, except 

  
 5 

 
that, in determining whether the Trustee shall be fully protected in making such calculation or in relying upon any such request, demand, authorization, direction, notice, consent or waiver or
upon any such determination as to the presence of a quorum, only Securities which a Responsible Officer of the Trustee actually knows to be so owned shall be so disregarded. Securities so owned which have been pledged in good faith may be regarded
as Outstanding if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to such Securities and that the pledgee is not the Company or any other obligor upon the Securities or any Affiliate of the
Company or of such other obligor. 
 “Paying Agent” means any Person authorized by the Company to pay the principal on the
Securities on behalf of the Company. The Paying Agent appointed by the Company shall initially be the Trustee. 
 “Person”
means any individual, corporation, partnership, joint venture, association, joint-stock company, limited liability company, trust, unincorporated organization or government or any agency or political subdivision thereof, or any other entity. 

“Place of Payment” means the place or places where the principal of any Securities are payable or where the Securities are
convertible into shares of Common Stock, and the initial Place of Payment shall be the Corporate Trust Office. 
 “Principal
Securities Exchanges” means the principal national securities exchange in the United States on which the Common Stock is listed or admitted to trading, it being understood that as of the date hereof the Principal Securities Exchanges are
the Nasdaq Global Market and the New York Stock Exchange; provided, that in the event the Common Stock is only listed or admitted to trading on one Principal Securities Exchange such exchange shall be the sole Principal Securities Exchange.

 “Property” has the meaning specified in Section 9.08. 

“Record Date” means, with respect to any dividend, distribution or other transaction or event in which the holders of Common
Stock have the right to receive any cash, securities or other property or in which the Common Stock (or other applicable security) is exchanged for or converted into any combination of cash, securities or other property, the date fixed for
determination of shareholders entitled to receive such cash, securities or other property (whether such date is fixed by the Board of Directors or by statute, contract or otherwise). 

“Redemption Agent” means the office or agency appointed by the Company where Securities may be presented for redemption. The
Redemption Agent appointed by the Company shall initially be the Trustee. 
 “Redemption Date” shall mean the fifth
Business Days after the receipt of a redemption notice by the Trustee. 
 “Reference Property” has the meaning specified in
Section 10.03. 
 “Registered Security” means any Security which is registered in the Security Register. 

  
 6 

 “Reorganization Event” has the meaning specified in Section 10.03. 

“Responsible Officer” means any officer of the Trustee assigned by the Trustee to administer its corporate trust matters and
who shall have direct responsibility for the administration of this Indenture. 
 “Securities Custodian” means the
custodian with respect to the Global Securities (as appointed by the Depositary), or any successor Person thereto and shall initially be the Trustee. 

“Security” or “Securities” has the meaning specified in the Recitals and, more particularly, means any
Security or Securities authenticated and delivered under this Indenture. 
 “Security Register” has the meaning specified
in Section 3.05. 
 “Security Registrar” has the meaning specified in Section 3.05. 

“Significant Subsidiary” means (1) CBI or (2) any Subsidiary that would be a “significant subsidiary” as
defined in Rule 1-02 of Regulation S-X, promulgated pursuant to the Securities Act of 1933, as amended, as such regulation is in effect on the date hereof. 

“Spin-Off” has the meaning specified in Section 10.02. 

“Stated Maturity Date” means February 19, 2018, which is the date that all principal on all Outstanding Securities is
due and payable. 
 “Subsidiary” means any Person a majority of the outstanding voting stock of which is owned, directly or
indirectly, by the Company or by one or more other Subsidiaries of the Company. For the purposes of this definition, “voting stock” means stock having voting power for the election of directors, whether at all times or only so long as no
senior class of stock has such voting power by reason of any contingency. 
 “Trading Day” means any Business Day on which
the Common Stock is traded, or able to be traded, on any of the Principal Securities Exchanges on which the Common Stock is listed or admitted to trading. 

“Trust Indenture Act” means the Trust Indenture Act of 1939, as amended, as in force at the date as of which this Indenture
was executed, except as provided in Section 8.05. 
 “Trustee” means the Person named as the “Trustee” in
the first paragraph of this Indenture until a successor Trustee shall have become such pursuant to the applicable provisions of this Indenture, and thereafter “Trustee” shall mean or include each Person who is then a Trustee
hereunder. 
 “United States” means the United States of America (including the states and the District of Columbia), its
territories, its possessions and other areas subject to its jurisdiction. 

  
 7 

 Section 1.02 Compliance Certificates and Opinions. 

(1) Upon any application or request by the Company to the Trustee to take any action under any provision of this Indenture, the Company shall
furnish to the Trustee an Officers’ Certificate stating that all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with, except that in the case of any such application or request as
to which the furnishing of such documents is specifically required by any provision of this Indenture relating to such particular application or request, no additional certificate or opinion need be furnished. 

Every certificate with respect to compliance with a condition or covenant provided for in this Indenture (other than pursuant to
Section 9.04) shall include: 
 (a) a statement that each individual signing such certificate has read such condition or covenant and
the definitions herein relating thereto; 
 (b) a brief statement as to the nature and scope of the examination or investigation upon which
the statements contained in such certificate are based; 
 (c) a statement that he or she has made such examination or investigation as is
necessary to enable such individual to express an informed opinion as to whether or not such condition or covenant has been complied with; and 

(d) a statement as to whether, in the opinion of each such individual, such condition or covenant has been complied with. 

(2) In the absence of bad faith or willful misconduct on its part, the Trustee may conclusively rely, as to the truth of the statements and
the correctness of the opinions expressed therein, upon certificates furnished to the Trustee and conforming to the requirements of this Indenture. However, in the case of any such certificates which by any provision hereof are specifically required
to be furnished to the Trustee, the Trustee shall examine the certificates to determine whether or not they conform on their face to the requirements of this Indenture, but need not confirm or investigate the accuracy of mathematical calculations or
other facts stated therein. 
 Section 1.03 Form of Documents Delivered to Trustee. 

In any case where several matters are required to be certified by any specified Person, it is not necessary that all such matters be certified
by only one such Person, or that they be so certified or covered by only one document. 
 Any certificate of an officer of the Company may
be based, insofar as it relates to legal matters, upon an Opinion of Counsel, or a certificate or representations by counsel, unless such officer knows, or in the exercise of reasonable care should know, that the opinion, certificate or
representations with respect to the matters upon which his certificate or opinion is based are erroneous. Any such Opinion of Counsel or certificate or representations may be based, insofar as it relates to factual matters, upon a certificate or
opinion of, or representations by, an officer or officers of the Company stating that the information as to such factual matters is in the possession of the Company, unless such counsel knows, or in the exercise of reasonable care should know, that
the certificate or opinion or representations as to such matters are erroneous. 

  
 8 

 Where any Person is required to make, give or execute two or more applications, requests,
consents, certificates, statements, opinions or other instruments under this Indenture, they may, but need not, be consolidated and form one instrument. 

Section 1.04 Acts of Holders. 
 (a)
Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by Holders may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by
such Holders in person or by agents duly appointed in writing. Except as herein otherwise expressly provided, such action shall become effective when such instrument or instruments or record or both are delivered to the Trustee and, where it is
hereby expressly required, to the Company. Such instrument or instruments and any such record (and the action embodied therein and evidenced thereby) are herein sometimes referred to as the “Act” of the Holders signing such
instrument or instruments or so voting at any such meeting. Proof of execution of any such instrument or of a writing appointing any such agent, or of the holding by any Person of a Security, shall be sufficient for any purpose of this Indenture and
conclusive in favor of the Trustee and the Company and any agent of the Trustee or the Company, if made in the manner provided in this Section 1.04. 

(b) The fact and date of the execution by any Person of any such instrument or writing may be proved by the affidavit of a witness of such
execution or by a certificate of a notary public or other officer authorized by law to take acknowledgments of deeds, certifying that the individual signing such instrument or writing acknowledged to him or her the execution thereof. Where such
execution is by a signer acting in a capacity other than his individual capacity, such certificate or affidavit shall also constitute sufficient proof of his authority. The fact and date of the execution of any such instrument or writing, or the
authority of the Person executing the same, may also be proved in any other manner that the Trustee deems reasonably sufficient. 
 (c) The
ownership of Securities shall be proved by the Security Register. 
 (d) If the Company shall solicit from the Holders of Securities any
request, demand, authorization, direction, notice, consent, waiver or other Act, the Company may, at its option, in or pursuant to a Board Resolution, fix in advance a record date for the determination of Holders entitled to give such request,
demand, authorization, direction, notice, consent, waiver or other Act, but the Company shall have no obligation to do so. Notwithstanding Section 316(c) of the Trust Indenture Act, such record date shall be the record date specified in or
pursuant to such Board Resolution, which shall be a date not earlier than the date 30 days prior to the first solicitation of Holders generally in connection therewith and not later than the date such solicitation is completed. If such a record date
is fixed, such request, demand, authorization, direction, notice, consent, waiver or other Act may be given before or after such record date, but only the Holders of record at the close of business on such record date shall be deemed to be Holders
for the purposes of determining whether Holders of the requisite proportion of Outstanding Securities have authorized or agreed or consented to such request, demand, authorization, direction, notice, consent, waiver or other Act, and for that
purpose the Outstanding Securities shall be computed as of such record date; provided that no such 

  
 9 

 
authorization, agreement or consent by the Holders on such record date shall be deemed effective unless it shall become effective pursuant to the provisions of this Indenture not later than six
months after the record date. 
 (e) Any request, demand, authorization, direction, notice, consent, waiver or other Act of the Holder of
any Security shall bind every future Holder of the same Security and the Holder of every Security issued upon the registration of transfer thereof or in exchange therefor or in lieu thereof in respect of anything done, omitted or suffered to be done
by the Trustee, any Security Registrar, any Escrow Agent, any Authenticating Agent or the Company in reliance thereon, whether or not notation of such action is made upon such Security. 

Section 1.05 Notices, Etc., to Trustee and the Company. 

Any request, demand, authorization, direction, notice, consent, waiver or Act of Holders or other document provided or permitted by this
Indenture shall be in writing and shall be deemed to have been duly given (a) on the date of delivery, if delivered personally or by facsimile, upon confirmation of receipt, (b) on the first Business Day following the date of dispatch if
delivered by a recognized next-day courier services or (c) on the third Business Day following the date of mailing if delivered by registered or certified mail, return receipt requested, postage prepaid, to the parties to this Agreement at the
following address or to such other address either party to this Agreement shall specify by notice to the other party: 
 (1) if to the
Trustee, addressed to it at American Stock Transfer & Trust Company, LLC, Administrative Support, 6201 15th Avenue, Brooklyn, NY 11219, Attn: Reorganization Department, facsimile at (718) 331-1852, or at any other address previously
furnished in writing to the Holders and the Company in accordance with this Section 1.05; or 
 (2) if to the Company, addressed to it
at Targacept, Inc., 100 North Main Street, Suite 1510, Winston-Salem, NC 27101 Attn: Dr. Stephen A. Hill, facsimile at (336) 480-2103, or at any other address previously furnished in writing to the Trustee and the Holders by the
Company in accordance with this Section 1.05. 
 Section 1.06 Notice to Holders; Waiver. 

Where this Indenture provides for notice of any event to Holders of Registered Securities by the Company or the Trustee, such notice shall be
sufficiently given (unless otherwise herein expressly provided) if in writing and mailed, first-class postage prepaid, to each such Holder affected by such event, at his, her or its address as it appears in the Security Register, not later than the
latest date, and not earlier than the earliest date, prescribed for the giving of such notice. In any case where notice to Holders of Registered Securities is given by mail, neither the failure to mail such notice, nor any defect in any notice so
mailed, to any particular Holder shall affect the sufficiency of such notice with respect to other Holders of Registered Securities given as provided herein. Any notice mailed to a Holder in the manner herein prescribed shall be conclusively deemed
to have been received by such Holder, whether or not such Holder actually receives such notice. 

  
 10 

 If by reason of the suspension of or irregularities in regular mail service or by reason of any
other cause it shall be impracticable to give such notice by mail, then such notification to Holders of Registered Securities as shall be made with the approval of the Trustee shall constitute a sufficient notification to such Holders for every
purpose hereunder. 
 Any request, demand, authorization, direction, notice, consent or waiver required or permitted under this Indenture
shall be in the English language. 
 Notwithstanding any other provision of this Indenture or any Security, whenever notice is required to
be given to a holder of a Global Security, such notice shall be sufficiently given if given to the Depositary for such Global Security (or its designee), pursuant to customary procedures of such Depositary. 

Where this Indenture provides for notice in any manner, such notice may be waived in writing by the Person entitled to receive such notice,
either before or after the event, and such waiver shall be the equivalent of such notice. Waivers of notice by Holders shall be filed with the Trustee, but such filing shall not be a condition precedent to the validity of any action taken in
reliance upon such waiver. 
 Section 1.07 Effect of Headings and Table of Contents. 

The Article and Section headings herein and the Table of Contents are for convenience only and shall not affect the construction hereof. 

Section 1.08 Successors and Assigns. 

All covenants and agreements in this Indenture by the Company shall bind its successors and assigns, whether so expressed or not. 

Section 1.09 Separability Clause. 

In case any provision in this Indenture or in any Security shall be invalid, illegal or unenforceable, the validity, legality and
enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 Section 1.10 Benefits of Indenture. 

Nothing in this Indenture or in the Securities, express or implied, shall give to any Person, other than the parties hereto, any Security
Registrar, any Paying Agent, any Authenticating Agent, any Conversion Agent, any Redemption Agent and their successors hereunder and the Holders any benefit or any legal or equitable right, remedy or claim under this Indenture. 

Section 1.11 No Security Interests Created 

Except as provided in the Escrow Agreement, nothing in this Indenture or the Securities, expressed or implied, shall be construed to create a
security interest under the Uniform Commercial Code or similar legislation, as now or hereafter enacted and in effect, in any jurisdiction. 

  
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 Section 1.12 Governing Law. 

This Indenture and the Securities shall be governed by and construed in accordance with the law of the State of New York. This Indenture is
subject to the provisions of the Trust Indenture Act that are required to be part of this Indenture and shall, to the extent applicable, be governed by such provisions. 

Section 1.13 Legal Holidays. 
 In any
case where the Stated Maturity Date or any Conversion Date shall not be a Business Day, then, payment of principal, or the provision of any shares of Common Stock need not be made on such date, but may be made on the next succeeding Business Day
with the same force and effect as if made on the Stated Maturity Date or such Conversion Date. 
 Section 1.14 Submission to Jurisdiction. 

The Company hereby irrevocably submits to the non-exclusive jurisdiction of any New York state or federal court sitting in The City of New York
in any action or proceeding arising out of or relating to the Indenture and the Securities, and the Company hereby irrevocably agrees that all claims in respect of such action or proceeding may be heard and determined in such New York state or
federal court. The Company hereby irrevocably waives, to the fullest extent it may effectively do so, the defense of an inconvenient forum to the maintenance of such action or proceeding. Any action or proceeding brought by or on behalf of any
Holder arising out of or relating to the Indenture and the Securities shall be brought exclusively in New York state or federal court sitting in The City of New York. 

Section 1.15 Conflict with Trust Indenture Act. 

If any provision hereof limits, qualifies or conflicts with any provision of the Trust Indenture Act or another provision which is required or
deemed to be included in this Indenture by any of the provisions of the Trust Indenture Act, the provision or requirement of the Trust Indenture Act shall control. If any provision of this Indenture modifies or excludes any provision of the Trust
Indenture Act that may be so modified or excluded, the latter provision shall be deemed to apply to this Indenture as so modified or to be excluded, as the case may be. 

Section 1.16 Counterparts. 
 This
Indenture may be executed in any number of counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument. 

  
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 ARTICLE II 

SECURITIES FORMS 
 Section 2.01
Form and Dating. 
 The Securities shall be issued initially as one or more Global Securities and/or Definitive Securities in the form
set forth on Exhibit A and Exhibit B, respectively, both of which are part of this Indenture and incorporated by reference herein. The Securities may have notations, legends or endorsements required by law, stock exchange rule or usage;
provided that any such notation, legend or endorsement required by usage is in a form acceptable to the Company. The Company shall provide any such notations, legends or endorsements to the Trustee in writing. Each Security shall be dated the
date of its authentication. 
 Section 2.02 Form of Trustee’s Certificate of Authentication. 

Subject to Section 5.11, the Trustee’s certificate of authentication shall be in substantially the following form: 

This is one of the Securities referred to in the within-mentioned Indenture. 

 

			
	 AMERICAN STOCK TRANSFER &
 TRUST
COMPANY, LLC, Trustee

		
	By:	 	  

		 	Authorized Officer

 Section 2.03 Global Security in General. 

Each Global Security shall represent such number of the Outstanding Securities as shall be specified therein and each shall provide that it
shall represent the aggregate amount of Outstanding Securities from time to time endorsed thereon and that the aggregate amount of Outstanding Securities represented thereby may from time to time be reduced or increased, as appropriate, to reflect
any exchanges, surrenders, conversions, transfers or cancellations. 
 Any adjustment of the aggregate principal amount of a Global Security
to reflect the amount of any increase or decrease in the amount of Outstanding Securities represented thereby shall be made by the Trustee and shall be made on the records of the Trustee and the Depositary. 

Section 2.04 Legends. 
 The Company
shall execute and the Trustee shall, in accordance with this Section 2.04, authenticate and deliver initially one or more Global Securities that (a) shall be registered in the name of the Depositary, (b) shall be delivered by the
Trustee to the Depositary or pursuant to the Depositary’s instructions and (c) shall bear legends substantially to the following effect: 

“UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION, TO
TARGACEPT, INC. (THE “COMPANY”) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE 

  
 13 

 
OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS
AN INTEREST HEREIN. TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS TO NOMINEES OF THE DEPOSITORY TRUST COMPANY OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE
LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF.” 
 Section 2.05
Definitive Securities. 
 Securities not issued as interests in the Global Securities will be issued in certificated definitive form
substantially in the form of Exhibit B attached hereto. 
 ARTICLE III 

THE SECURITIES 
 Section 3.01
Title; Amount and General Information. 
 (1) The Securities shall be known and designated as the “Redeemable Convertible
Notes”; 
 (2) The aggregate principal amount of Securities which may be authenticated and delivered under this Indenture is limited to
$37 million (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other Securities pursuant to Sections 3.04, 3.05, 3.06, 8.06, and except for any Securities which, pursuant to
Section 3.03, are deemed never to have been authenticated and delivered hereunder); 
 (3) The principal of any Outstanding Securities
shall be due on the Stated Maturity Date; 
 (4) The Securities shall not bear interest; 

(5) All principal of Securities shall be payable, all shares of Common Stock provided upon conversion, all Definitive Securities may be
surrendered for registration of transfer, exchange or conversion, as applicable, and all notices or demands to or upon the Company in respect of the Securities and this Indenture may be served at the Corporate Trust Office in the City of New York or
any other Place of Payment designated by the Company after the provision of notice of such designation by the Company to the Trustee and the Holders; and 

(6) The Trustee shall be the initial Paying Agent, Security Registrar, Conversion Agent, Redemption Agent and Securities Custodian. 

  
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 Section 3.02 Denominations. 

The Securities initially shall be issuable in denominations of $1.00 and any multiple thereof. 

Section 3.03 Execution, Authentication, Delivery and Dating. 

The Securities shall be executed on behalf of the Company by any one of its Chairman of the Board of Directors, its Chief Executive Officer,
its President, its Chief Financial Officer or a Vice President and by one of its Secretary or its Controller, under its corporate seal reproduced thereon, and attested by its Secretary. The signature of such officers on the Securities may be manual
or facsimile signatures of the present or any future such authorized officer and may be imprinted or otherwise reproduced on the Securities. 

Securities bearing the manual or facsimile signatures of individuals who were at any time the proper officers of the Company shall bind the
Company, notwithstanding that such individuals or any of them have ceased to hold such offices prior to the authentication and delivery of such Securities or did not hold such offices at the date of such Securities. 

The Trustee shall authenticate and deliver Securities for original issue in an aggregate principal amount of up to $37 million upon a Company
Order without any further action by the Company. The aggregate principal amount of Securities outstanding at any time may not exceed the amount set forth in the foregoing sentence. 

Each Registered Security shall be dated the date of its authentication as contemplated by Section 3.01. 

No Security shall be entitled to any benefit under this Indenture or be valid or obligatory for any purpose unless there appears on such
Security a certificate of authentication substantially in the form provided for herein duly executed by the Trustee or an Authenticating Agent by signature of an authorized signatory, and such certificate upon any Security shall be conclusive
evidence, and the only evidence, that such Security has been duly authenticated and delivered hereunder and is entitled to the benefits of this Indenture. Notwithstanding the foregoing, if any Security shall have been authenticated and delivered
hereunder but never issued and sold by the Company, and the Company shall deliver such Security to the Trustee for cancellation as provided in Section 3.09 together with a written statement (which need not comply with Section 1.02 and need
not be accompanied by an Opinion of Counsel) stating that such Security has never been issued and sold by the Company, for all purposes of this Indenture such Security shall be deemed never to have been authenticated and delivered hereunder and
shall never be entitled to the benefits of this Indenture. 
 Section 3.04 Temporary Securities. 

Pending the preparation of any Global or Definitive Securities, the Company may execute, and upon Company Order the Trustee shall authenticate
and deliver, temporary Securities which are printed, lithographed, typewritten, mimeographed or otherwise produced, in any authorized denomination, substantially of the tenor of the Global or Definitive Securities in lieu of which they are issued,
in registered form and with such appropriate insertions, omissions, substitutions and other variations as the officers executing such Securities may determine, as conclusively evidenced by their execution of such Securities. Such temporary
Securities may be in global form. 

  
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 If temporary Securities are issued, the Company will cause Definitive Securities to be prepared
without unreasonable delay. After the preparation of Definitive Securities, the temporary Securities shall be exchangeable for Definitive Securities upon surrender of the temporary Securities at the Corporate Trust Office, without charge to the
Holder. Upon surrender for cancellation of any one or more temporary Securities, the Company shall execute and the Trustee shall authenticate and deliver in exchange therefor a like principal amount and like tenor of Definitive Securities of
authorized denominations. Until so exchanged, the temporary Securities shall in all respects be entitled to the same benefits under this Indenture as Definitive Securities. 

Section 3.05 Registration, Transfer and Exchange. 

The Company shall cause to be kept at the Corporate Trust Office of the Trustee or in any office or agency of the Company in a Place of Payment
a register for the Securities (the registers maintained in such office or in any such office or agency of the Company in a Place of Payment being herein sometimes referred to collectively as the “Security Register”) in which,
subject to such reasonable instructions as it may prescribe, the Company shall provide for the registration of Registered Securities and of transfers of Registered Securities. The Security Register shall be in written form or any other form capable
of being converted into written form within a reasonable time. The Trustee, at its Corporate Trust Office, is hereby initially appointed “Security Registrar” for the purpose of registering Registered Securities and transfers of
Registered Securities on such Security Register as herein provided and for facilitating exchanges of temporary Global Securities for permanent Global Securities or Definitive Securities, or both, or of permanent Global Securities for Definitive
Securities, or both, as herein provided. In the event that the Trustee shall cease to be Security Registrar, it shall have the right to examine the Security Register at all reasonable times. 

Upon surrender for registration of transfer of any Registered Security at any office or agency of the Company in a Place of Payment, the
Company shall execute, and the Trustee shall authenticate and deliver, in the name of the designated transferee or transferees, one or more new Registered Securities, of any authorized denominations and of a like aggregate principal amount, bearing
a number not contemporaneously outstanding and containing identical terms and provisions. 
 At the option of the Holder, Registered
Securities may be exchanged for other Registered Securities, of any authorized denomination or denominations and of a like aggregate principal amount, containing identical terms and provisions, upon surrender of the Registered Securities to be
exchanged at any such office or agency. Whenever any Registered Securities are so surrendered for exchange, the Company shall execute, and the Trustee shall authenticate and deliver, the Registered Securities which the Holder making the exchange is
entitled to receive. 
 Whenever any Securities are so surrendered for exchange, the Company shall execute, and the Trustee shall
authenticate and deliver, the Securities which the Holder making the exchange is entitled to receive. 

  
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 Notwithstanding the foregoing, any permanent Global Security shall be exchangeable only as
provided in this paragraph. If any beneficial owner of an interest in a permanent Global Security is entitled to exchange such interest for Securities of like tenor and principal amount of another authorized form and denomination, provided
that any applicable notice provided in the permanent Global Security shall have been given, then without unnecessary delay but in any event not later than the earliest date on which such interest may be so exchanged, the Company shall deliver to the
Trustee Definitive Securities in aggregate principal amount equal to the principal amount of such beneficial owner’s interest in such permanent Global Security, executed by the Company. On or after the earliest date on which such interests may
be so exchanged, such permanent Global Security shall be surrendered by the Depositary or such other depositary as shall be specified in the Company Order with respect thereto to the Trustee, as the Company’s agent for such purpose, or to the
Security Registrar, to be exchanged, in whole or from time to time in part, for Definitive Securities without charge and the Trustee shall authenticate and deliver, in exchange for each portion of such permanent Global Security, an equal aggregate
principal amount of Definitive Securities of authorized denominations and of like tenor as the portion of such permanent Global Security to be exchanged which shall be in the form of Registered Securities as shall be specified by the beneficial
owner thereof. 
 All Securities issued upon any registration of transfer or exchange of Securities shall be valid obligations of the
Company, evidencing the same debt and entitled to the same benefits under this Indenture, as the Securities surrendered upon such registration of transfer or exchange. 

Every Registered Security presented or surrendered for registration of transfer or for exchange shall (if so required by the Company or the
Security Registrar or any transfer agent) be duly endorsed, or be accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder thereof or his attorney or any transfer
agent duly authorized in writing. 
 No service charge shall be made for any registration of transfer or exchange of Securities, but the
Company or the Trustee may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection with any registration of transfer or exchange of Securities, other than exchanges pursuant to
Section 3.04 or 8.06 not involving any transfer. 
 Section 3.06 Mutilated, Destroyed, Lost and Stolen Securities. 

If any mutilated Security is surrendered to the Trustee or the Company, together with, in proper cases, such security or indemnity as may be
required by the Company or the Trustee to save each of them or any agent of either of them harmless, the Company shall execute and the Trustee shall authenticate and deliver in exchange therefor a new Security of the same principal amount,
containing identical terms and provisions and bearing a number not contemporaneously outstanding. 
 If there shall be delivered to the
Company and to the Trustee (i) evidence to their satisfaction of the destruction, loss or theft of any Security, and (ii) such security or indemnity as may be required by them to save each of them and any agent of either of them harmless,
then the Company shall, subject to the following paragraph, execute and upon its request the Trustee shall 

  
 17 

 
authenticate and deliver, in lieu of any such destroyed, lost or stolen Security, a new Security of the same principal amount, containing identical terms and provisions and bearing a number not
contemporaneously outstanding. 
 Upon the issuance of any new Security under this Section 3.06, the Company may require the payment of
a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith. 

Every new Security issued pursuant to this Section 3.06 in lieu of any destroyed, lost or stolen Security shall constitute an original
additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be entitled to all the benefits of this Indenture equally and proportionately with any and
all other Securities duly issued hereunder. 
 The provisions of this Section 3.06 are exclusive and shall preclude (to the extent
lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities. 
 Section 3.07
Persons Deemed Owners. 
 Prior to due presentment of a Registered Security for registration of transfer, the Company, the Trustee and
any agent of the Company or the Trustee may treat the Person in whose name such Registered Security is registered as the owner of such Registered Security for the purpose of receiving payment of principal of such Registered Security and for all
other purposes whatsoever, and neither the Company, the Trustee nor any agent of the Company or the Trustee shall be affected by notice to the contrary. 

None of the Company, the Trustee, any Paying Agent or the Security Registrar will have any responsibility or liability for any aspect of the
records relating to or payments made on account of beneficial ownership interests of a Security in global form or for maintaining, supervising or reviewing any records relating to such beneficial ownership interests. 

Notwithstanding the foregoing, with respect to any Global Security, whether permanent or temporary, nothing herein shall prevent the Company,
the Trustee, or any agent of the Company or the Trustee, from giving effect to any written certification, proxy or other authorization furnished by any Depositary, as a Holder, with respect to such Global Security or impair, as between such
Depositary and owners of beneficial interests in such Global Security, the operation of customary practices governing the exercise of the rights of such Depositary (or its nominee) as Holder of such Global Security. 

Section 3.08 Book-Entry Provisions for the Global Securities. 

(1) Any Global Securities shall initially: 

(a) be registered in the name of the Depositary; 

  
 18 

 (b) be delivered to the Trustee as the Securities Custodian for the Depositary; and 

(c) bear the legend set forth in Section 2.04. 

(2) Agent Members shall have no rights under this Indenture with respect to any Global Security held on their behalf by the Depositary, or the
Trustee as its custodian, or under such Global Security, and the Depositary may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner of such Global Security for all purposes whatsoever.
Notwithstanding the foregoing, nothing contained herein shall prevent the Company, the Trustee or any agent of the Company or Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary or
impair, as between the Depositary and the Agent Members, the operation of customary practices governing the exercise of the rights of a Holder of any Security. 

(3) The Holder of a Global Security may grant proxies and otherwise authorize any Person, including Agent Members and Persons that may hold
interests through Agent Members, to take any action which a Holder is entitled to take under this Indenture or the Securities. 
 (4) A
Global Security may not be transferred, in whole or in part, to any Person other than the Depositary (or a nominee thereof), and no such transfer to any such other Person may be registered. Beneficial interests in a Global Security may be
transferred in accordance with the rules and procedures of the Depositary. 
 (5) If at any time: 

(a) the Depositary notifies the Company in writing that it is unwilling or unable to continue to act as Depositary for the Global Securities
and a successor Depositary for the Global Securities is not appointed by the Company within 90 days of such notice; 
 (b) the Depositary
ceases to be registered as a “clearing agency” under the Exchange Act and a successor depositary for the Global Securities is not appointed by the Company within 90 days of such cessation; 

(c) the Company, at its option, notifies the Trustee in writing that it elects to cause the issuance of the Definitive Securities under this
Indenture in exchange for all or any part of the Securities represented by a Global Security or Global Securities, subject to the procedures of the Depositary; or 

(d) an Event of Default has occurred and is continuing and the Registrar has received a request from the Depositary for the issuance of
Definitive Securities in exchange for such Global Security or Global Securities; 
 the Depositary shall surrender such Global Security or Global Securities
to the Trustee for cancellation and the Company shall execute, and the Trustee, upon receipt of an Officers’ Certificate and Company Order for the authentication and delivery of Securities, shall authenticate and deliver in exchange for such
Global Security or Global Securities, Definitive Securities in an aggregate principal amount equal to the aggregate principal amount of such 

  
 19 

 
Global Security or Global Securities. Such certificated Securities shall be registered in such names as the Depositary shall identify in writing as the beneficial owners of the Securities
represented by such Global Security or Global Securities (or any nominee thereof). 
 (6) Notwithstanding the foregoing, in connection with
any transfer of beneficial interests in a Global Security to the beneficial owners thereof pursuant to subsection (5) of this Section 3.08, the Registrar shall reflect on its books and records the date and a decrease in the principal
amount of such Global Security in an amount equal to the principal amount of the beneficial interests in such Global Security to be transferred. 

Section 3.09 Cancellation. 
 (1) All
Securities surrendered for payment, registration of transfer or exchange or conversion, if surrendered to any Person other than the Trustee, shall be delivered to the Trustee, and any such Securities surrendered directly to the Trustee for any such
purpose shall be promptly cancelled by the Trustee. The Company may at any time deliver to the Trustee for cancellation any Securities previously authenticated and delivered hereunder which the Company may have acquired in any manner whatsoever, and
may deliver to the Trustee (or to any other Person for delivery to the Trustee) for cancellation any Securities previously authenticated hereunder which the Company has not issued and sold, and all Securities so delivered shall be promptly cancelled
by the Trustee. No Securities shall be authenticated in lieu of or in exchange for any Securities cancelled as provided in this Section 3.09, except as expressly permitted by this Indenture. Cancelled Securities held by the Trustee shall be
destroyed by the Trustee in accordance with its customary procedures, unless by a Company Order the Company directs the Trustee to deliver a certificate of such destruction to the Company or to return them to the Company. 

(2) At such time as all beneficial interests in a Global Security have either been exchanged for other Securities, surrendered for payment,
converted, transferred or canceled, such Global Security shall be returned by the Depositary to the Trustee for cancellation or retained and canceled by the Trustee. At any time prior to such cancellation, if any beneficial interest in a Global
Security is exchanged for other Securities, surrendered for payment, converted, transferred or canceled, the principal amount of Securities represented by such Global Security shall be reduced and an adjustment shall be made on the books and records
of the Trustee (if it is then the Securities Custodian for such Global Security) or other Securities Custodian with respect to such Global Security, by the Trustee or the Securities Custodian, to reflect such reduction. 

Section 3.10 CUSIP Numbers. 
 The
Committee on Uniform Securities Identification Procedures (“CUSIP”) number for the Securities is 87611R AA6. No notice or exchange shall be affected by any defect in or omission of such CUSIP number, and the Company shall notify the
Trustee in writing as promptly as practicable of any change in the CUSIP number. 

  
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 Section 3.11 Withholding. 

(1) The Company (through the Paying Agent or otherwise) shall be entitled to reduce or otherwise set-off against any payments made or deemed
made by the Company to Holders in respect of the provision of shares of Common Stock for any amounts the Company believes it is required to withhold by law. For the avoidance of doubt, if the Company pays any withholding taxes on behalf of Holders
as a result of an adjustment to the Conversion Rate of the Securities, the Company may, at its option, set-off such payments against payments of cash and Common Stock in respect of the Securities. Any amounts withheld pursuant to this
Section 3.11 shall be paid over by the Company (through the Paying Agent or otherwise) to the appropriate taxing authority. 
 (2)
Prior to or upon the occurrence of any event that results in an actual or deemed payment by the Company to Holders in respect of the Securities, the Company (through the Trustee, Paying Agent, Withholding Agent, or otherwise) may request a Holder to
furnish any appropriate documentation that may be required in order to determine the Company’s withholding obligations under applicable law (including a United States Internal Revenue Service Form W-9, Form W-8BEN, Form W-8ECI, or any
certifications prepared by the Company or on its behalf in order to enable the Company to attempt to comply with its potential withholding obligations under any tax laws). Upon the receipt of any such documentation, or in the event no such
documentation is provided, the Company (through the Trustee, Paying Agent or otherwise) will withhold pursuant to this Section 3.11 to the extent required by applicable law. 

ARTICLE IV 
 REMEDIES

 Section 4.01 Events of Default. 

“Event of Default” means any one of the following events (whatever the reason for such Event of Default and whether or not it
shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or governmental body): 

(1) default in the payment of the principal of any Security when due and payable at the Stated Maturity Date; 

(2) failure by the Company to deliver shares of Common Stock required to be delivered upon conversion of a Security in accordance with Article
Ten within 5 Business Days after the applicable Conversion Date; 
 (3) failure by the Company to deliver cash payment required to be
delivered upon redemption of a Security in accordance with Article Eleven within 5 Business Days after the applicable Redemption Date; 

(4) the Escrow Agreement ceases to be in full force and effect or enforceable prior to its expiration in accordance with its terms; 

(5) the Company or any Significant Subsidiary: 

  
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 (a) commences a voluntary case or proceeding under any Bankruptcy Law; 

(b) consents to the commencement of any bankruptcy or insolvency case or proceeding against it, or files a petition or answer or consent
seeking reorganization or relief against it; 
 (c) consents to the entry of a decree or order for relief against it in an involuntary case
or proceeding; 
 (d) consents to the filing of such petition or to the appointment of or taking possession by a Custodian of the Company or
for all or substantially all of its property; or 
 (e) makes an assignment for the benefit of creditors, or admits in writing of its
inability to pay its debts generally as they become due or takes any corporate action in furtherance of any such action; or 
 (6) a court
of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 
 (a) is for relief against the Company or any
Significant Subsidiary in an involuntary case or proceeding; 
 (b) adjudges the Company or any Significant Subsidiary bankrupt or
insolvent, or approves as properly filed a petition seeking reorganization, arrangement, adjustment or composition of or in respect of the Company; 

(c) appoints a Custodian of the Company or any Subsidiary or for all or substantially all of the Company’s or any Significant
Subsidiary’s property; or 
 (d) orders the winding up or liquidation of the Company or any Significant Subsidiary; 

and the continuance of any such decree or order for relief or any such other decree or order unstayed and in effect for a period of 90
consecutive days. 
 Section 4.02 Acceleration of Maturity. 

If an Event of Default (other than an Event of Default specified in Section 4.01(5) or Section 4.01(6) with respect to the Company)
occurs and is continuing, then and in every such case the Trustee or the Holders of not less than 51% in principal amount of the Outstanding Securities may declare the principal of all the Securities to be due and payable immediately, by a notice in
writing to the Company (and to the Trustee if given by the Holders), and upon any such declaration such principal or specified portion thereof shall become immediately due and payable. If an Event of Default specified in Section 4.01(5) or
Section 4.01(6) with respect to the Company occurs, the principal of all of the Securities shall become immediately due and payable without any declaration or other Act of the Holders or any act on the part of the Trustee. 

  
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 This Section 4.02, however, is subject to the conditions that if, at any time after the
principal of the Securities shall have been so declared due and payable, and before any judgment or decree for the payment of the monies due shall have been obtained or entered as hereinafter provided, the Company shall pay or shall deposit with the
Trustee (from the Escrow Account or otherwise) a sum sufficient to pay, the principal of any and all Securities that shall have become due and the amounts due to the Trustee pursuant to Section 5.05, and if (1) rescission would not
conflict with any judgment or decree of a court of competent jurisdiction and (2) any and all Events of Defaults under this Indenture with respect to such Securities, other than the nonpayment of principal of such Securities that shall have
become due solely by such acceleration or failure to deliver amounts due upon conversion, shall have been cured or waived pursuant to Section 4.13, then and in every such case the Holders of a majority in aggregate principal amount of the
Outstanding Securities, by written notice to the Company and to the Trustee, may waive all Defaults or Events of Default with respect to the Securities and rescind and annul such declaration and its consequences and such Default shall cease to
exist, and any Event of Default arising therefrom shall be deemed to have been cured for every purpose of this Indenture; but no such waiver or rescission and annulment shall extend to or shall affect any subsequent Default or Event of Default, or
shall impair any right consequent thereon. The Company shall notify the Trustee in writing, promptly upon becoming aware thereof, of any Event of Default by delivering to the Trustee a statement specifying such Event of Default and any action the
Company has taken, is taking or proposes to take with respect thereto. No rescission or annulment referred to above shall affect any subsequent Default or impair any right consequent thereon. 

Section 4.03 Collection of Indebtedness and Suits for Enforcement by Trustee. 

The Company covenants that if default is made in the payment of the principal of any Security after the Stated Maturity Date, then the Company
will, upon demand of the Trustee, pay to the Trustee, for the benefit of the Holders, the whole amount then due and payable on such Securities for principal, and, in addition thereto, such further amount as shall be sufficient to cover the costs and
expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 

If the Company fails to pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an express trust, may
institute a judicial proceeding for the collection of the sums so due and unpaid, and may prosecute such proceeding to judgment or final decree, and may enforce the same against the Company or any other obligor upon the Securities and collect the
moneys adjudged or decreed to be payable in the manner provided by law out of the property of the Company or any other obligor upon the Securities, wherever situated. 

If an Event of Default with respect to the Securities occurs and is continuing, the Trustee may in its discretion proceed to protect and
enforce its rights and the rights of the Holders by such appropriate judicial proceedings as the Trustee shall deem most effectual to protect and enforce any such rights, whether for the specific enforcement of any covenant or agreement in this
Indenture or in aid of the exercise of any power granted herein, or to enforce any other proper remedy. 

  
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 Section 4.04 Trustee May File Proofs of Claim. 

In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other
judicial proceeding relating to the Company or the property of the Company or its creditors, the Trustee (irrespective of whether the principal of the Securities shall then be due and payable as therein expressed or by declaration or otherwise and
irrespective of whether the Trustee shall have made any demand on the Company for the payment of any overdue principal) shall be entitled and empowered, by intervention in such proceeding or otherwise: 

(i) to file and prove a claim for the whole amount of principal owing in respect of the Securities and to file such other papers or documents
(and take such other actions, including serving on a committee of creditors) as may be necessary or advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation, expenses, disbursements and advances of
the Trustee, its agents and counsel) and of the Holders allowed in such judicial proceeding; and 
 (ii) to collect and receive any moneys
or other property payable or deliverable on any such claims and to distribute the same; 
 and any custodian, receiver, assignee, trustee, liquidator,
sequestrator (or other similar official) in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee, and, in the event that the Trustee shall consent to the making of such payments directly to the
Holders, to pay to the Trustee any amount due to it for the reasonable compensation, expenses, disbursements and advances of the Trustee and any predecessor Trustee, their agents and counsel, and any other amounts due the Trustee or any predecessor
Trustee under Section 5.05. 
 Subject to Article Seven and Section 8.02, nothing herein contained shall be deemed to authorize
the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan of reorganization, arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof, or to authorize the Trustee to vote in
respect of the claim of any Holder in any such proceeding. 
 Section 4.05 Trustee May Enforce Claims Without Possession of Securities. 

All rights of action and claims under this Indenture or any of the Securities may be prosecuted and enforced by the Trustee without the
possession of any of the Securities or the production thereof in any proceeding relating thereto, and any such proceeding instituted by the Trustee shall be brought in its own name and as trustee of an express trust, and any recovery of judgment
shall, after provision for the payment of the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, be for the ratable benefit of the Holders of the Securities in respect of which such judgment has
been recovered. 
 Section 4.06 Application of Money Collected. 

Any money collected by the Trustee pursuant to this Article Four shall be applied in the following order, at the date or dates fixed by the
Trustee and, in case of the distribution of such money on account of principal upon presentation of the Securities, or both, as the case may be, and the notation thereon of the payment if only partially paid and upon surrender thereof if fully paid:

  
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 FIRST: To the payment of all amounts due the Trustee and any predecessor Trustee under
Section 5.05; 
 SECOND: To the payment of the amounts then due and unpaid upon the Securities for principal in respect of which or for
the benefit of which such money has been collected, ratably, without preference or priority of any kind, according to the aggregate amounts due and payable on such Securities; and 

THIRD: To the payment of the remainder, if any, to the Company or any other Person or Persons entitled thereto. 

Section 4.07 Limitation on Suits. 

No Holder shall have any right to pursue any remedy, with respect to this Indenture, or for the appointment of a receiver or trustee, or for
any other remedy hereunder, unless: 
 (1) such Holder has previously given written notice to the Trustee of a continuing Event of Default;

 (2) the Holders of not less than 51% in principal amount of the Outstanding Securities shall have made written request to the Trustee to
pursue any remedy; 
 (3) such Holder or Holders have offered to the Trustee reasonable indemnity against the costs, expenses and
liabilities to be incurred in compliance with such written request; 
 (4) the Trustee for 60 days after its receipt of such notice, written
request and offer of indemnity has failed to comply with such written request; and 
 (5) no direction inconsistent with such written
request has been given to the Trustee during such 60-day period by the Holders of a majority in principal amount of the Outstanding Securities; 

it being understood and intended that no one or more of such Holders shall have any right in any manner whatever by virtue of, or by availing
of, any provision of this Indenture to affect, disturb or prejudice the rights of any other of such Holders, or to obtain or to seek to obtain priority or preference over any other of such Holders or to enforce any right under this Indenture, except
in the manner herein provided and for the equal and ratable benefit of all such Holders. 
 Section 4.08 Unconditional Right of Holders to Receive
Payment, to Redeem and to Convert. 
 Notwithstanding any other provision in this Indenture, the Holder of any Security shall have the
right which is absolute and unconditional to receive payment of the principal of such Security on the Stated Maturity Date expressed in such Security, to redeem such Security in accordance with Article 11, and to convert such Security in accordance
with Article Ten, and to institute suit for the enforcement of any such payment, and such rights shall not be impaired without the consent of such Holder. 

  
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 Section 4.09 Restoration of Rights and Remedies. 

If the Trustee or any Holder has instituted any proceeding to enforce any right or remedy under this Indenture and such proceeding has been
discontinued or abandoned for any reason, or has been determined adversely to the Trustee or to such Holder, then and in every such case the Company, the Trustee and the Holders shall, subject to any determination in such proceeding, be restored
severally and respectively to their former positions hereunder and thereafter all rights and remedies of the Trustee and the Holders shall continue as though no such proceeding had been instituted. 

Section 4.10 Rights and Remedies Cumulative. 

Except as otherwise provided with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities in the last
paragraph of Section 3.06, no right or remedy herein conferred upon or reserved to the Trustee or to the Holders is intended to be exclusive of any other right or remedy, and every right and remedy shall, to the extent permitted by law, be
cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent
assertion or employment of any other appropriate right or remedy. 
 Section 4.11 Delay or Omission Not Waiver. 

No delay or omission of the Trustee or of any Holder to exercise any right or remedy accruing upon any Event of Default shall impair any such
right or remedy or constitute a waiver of any such Event of Default or an acquiescence therein. Every right and remedy given by this Article Four or by law to the Trustee or to the Holders may be exercised from time to time, and as often as may be
deemed expedient, by the Trustee or by the Holders, as the case may be. 
 Section 4.12 Control by Holders of Securities. 

The Holders of a majority in principal amount of the Outstanding Securities shall have the right to direct the time, method and place of
conducting any proceeding for any remedy available to the Trustee or exercising any trust or power conferred on the Trustee with respect to the Securities, provided that: 

(1) such direction shall not be in conflict with any rule of law or with this Indenture; 

(2) the Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such direction; and 

(3) the Trustee need not take any action which might involve it in personal liability or be unjustly prejudicial to the Holders not
consenting. 

  
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 Section 4.13 Waiver of Past Defaults. 

Subject to Section 4.02, the Holders of not less than a majority in principal amount of the Outstanding Securities may on behalf of the
Holders of all the Securities waive any past default hereunder with respect to the Securities and its consequences, except a default: 
 (1)
in the payment of the principal of any Security; 
 (2) in respect of the right to convert any Security in accordance with Article Ten; or

 (3) in respect of a covenant or provision hereof which under Article Eight cannot be modified or amended without the consent of the
Holder of each Outstanding Security affected. 
 Upon any such waiver, such default shall cease to exist, and any Event of Default arising
therefrom shall be deemed to have been cured, for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other default or Event of Default or impair any right consequent thereon. 

Section 4.14 Waiver of Stay or Extension Laws. 

The Company covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, or plead, or in any manner
whatsoever claim or take the benefit or advantage of, any stay or extension law wherever enacted, now or at any time hereafter in force, which may affect the covenants or the performance of this Indenture; and the Company (to the extent that it may
lawfully do so) hereby expressly waives all benefit or advantage of any such law, and covenants that it will not hinder, delay or impede the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every such
power as though no such law had been enacted. 
 Section 4.15 Undertaking for Costs. 

In any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken, suffered
or omitted by it as Trustee, a court may require any party litigant in such suit to file an undertaking to pay the costs of such suit, and may assess reasonable costs, including reasonable attorneys’ fees and expenses, against any such party
litigant, in the manner and to the extent provided in the Trust Indenture Act; provided, that neither this Section nor the Trust Indenture Act shall be deemed to authorize any court to require such an undertaking or to make such an assessment in any
suit instituted by the Company or in any suit for the enforcement of the right to convert any Security in accordance with Article Ten. 

ARTICLE V 
 THE TRUSTEE

 Section 5.01 Duties of Trustee and Notice of Defaults. 

Subject to the provisions of Sections 315(a) through 315(d) of the Trust Indenture Act: 

(1) If a Default or an Event of Default has occurred and is continuing, the Trustee shall exercise such of the rights and powers vested in it
by this Indenture and use the same degree of care and skill in its exercise thereof as a prudent Person would exercise or use under the circumstances in the conduct of his own affairs; 

  
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 (2) Except during the continuance of a Default or an Event of Default, the Trustee need perform
only those duties as are specifically set forth in this Indenture and no covenants or obligations shall be implied in this Indenture that are adverse to the Trustee; 

(3) The Trustee may not be relieved from liability for its own negligent action, its own negligent failure to act or its own willful
misconduct, except that: 
 (a) this subsection (3) does not limit the effect of subsection (2) of Section 1.02 or subsection
(2) of this Section 5.01; 
 (b) the Trustee shall not be liable for any error of judgment made in good faith by a Responsible
Officer, unless it is proved that the Trustee was negligent in ascertaining the pertinent facts; and 
 (c) the Trustee shall not be liable
with respect to any action it takes or omits to take in good faith, in accordance with a direction of the Holders of a majority in principal amount of Outstanding Securities relating to the time, method and place of conducting any proceeding for any
remedy available to the Trustee or exercising any trust or power confirmed upon the Trustee under this Indenture; 
 (4) No provision of
this Indenture shall require the Trustee to expend or risk its own funds or otherwise incur any financial liability in the performance of any of its duties hereunder or in the exercise of any of its rights or powers if it shall have reasonable
grounds for believing that repayment of such funds or adequate indemnity against such risk or liability is not reasonably assured to it; and 

(5) The Trustee shall not be liable for interest on any money or assets received by it or held by it in trust except as the Trustee may agree
in writing with the Company. Money held by the Trustee in trust hereunder need not be segregated from other funds except to the extent required by law. 

Within 30 days after the occurrence of any Default hereunder with respect to the Securities, the Trustee shall transmit in the manner and to
the extent provided in Section 313(c) of the Trust Indenture Act, notice of such Default hereunder known to the Trustee (a “Notice of Default”), unless such Default shall have been cured or waived; provided, however,
that, except in the case of a Default in the payment of the principal of any Security on the Stated Maturity Date, the Trustee shall be protected in withholding such Notice of Default if and so long as the board of directors, the executive committee
or a trust committee of directors and/or Responsible Officers of the Trustee in good faith determine that the withholding of such notice is in the interest of the Holders. 

Section 5.02 Certain Rights of Trustee. 

Subject to Section 5.01 and the provisions of Sections 315(a) through 315(d) of the Trust Indenture Act: 

  
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 (1) The Trustee may conclusively rely on, and shall be fully protected in acting or refraining
from acting upon, any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, coupon or other paper or document believed by it to be genuine and to have been signed or
presented by the proper party or parties; 
 (2) Any request or direction of the Company mentioned herein shall be sufficiently evidenced by
a Company Request or Company Order (other than delivery of any Security to the Trustee for authentication and delivery pursuant to Section 3.03 which shall be sufficiently evidenced as provided therein) and any resolution of the Board of
Directors may be sufficiently evidenced by a Board Resolution; 
 (3) Whenever in the administration of this Indenture the Trustee shall
deem it desirable that a matter be proved or established prior to taking, suffering or omitting any action hereunder, the Trustee (unless other evidence be herein specifically prescribed) may, in the absence of bad faith on its part, conclusively
rely upon a Board Resolution, an Opinion of Counsel or an Officers’ Certificate; 
 (4) The Trustee may consult with counsel and the
written advice of such counsel or any Opinion of Counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in reliance thereon; 

(5) The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or
direction of any of the Holders pursuant to this Indenture, unless such Holders shall have offered to the Trustee reasonable security or indemnity satisfactory to it against the costs, expenses and liabilities which might be incurred by it in
compliance with such request or direction; 
 (6) The Trustee shall not be bound to make any investigation into the facts or matters stated
in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, coupon or other paper or document, but the Trustee, in its discretion, may make such further inquiry or
investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled upon reasonable notice and at reasonable times during normal business hours to
examine the books, records and premises of the Company, personally or by agent or attorney; 
 (7) The Trustee may execute any of the trusts
or powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it
hereunder; 
 (8) The Trustee shall not be deemed to have notice of any Default or Event of Default unless a Responsible Officer of the
Trustee has actual knowledge thereof or unless written notice of any event which is in fact such a default is sent to the Trustee at the Corporate Trust Office of the Trustee, and such notice references the Securities and this Indenture; 

  
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 (9) The rights, privileges, protections, immunities and benefits given to the Trustee, including
its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder; 
 (10) The
permissive rights of the Trustee enumerated herein shall not be construed as duties; and 
 (11) The Trustee may request that the Company
deliver an Officers’ Certificate setting forth the names of individuals and/or titles of officers authorized at such time to take specified actions pursuant to this Indenture, which Officers’ Certificate may be signed by any person
authorized to sign an Officers’ Certificate, including any person specified as so authorized in any such certificate previously delivered and not superseded. 

The Trustee shall not be required to expend or risk its own funds or otherwise incur any financial liability in the performance of any of its
duties hereunder, or in the exercise of any of its rights or powers, if it shall have reasonable grounds for believing that repayment of such funds or adequate indemnity against such risk or liability is not reasonably assured to it. 

Section 5.03 Not Responsible for Recitals or Issuance of Securities. 

The recitals contained herein and in the Securities, except the Trustee’s certificate of authentication, shall be taken as the statements
of the Company, and neither the Trustee nor any Authenticating Agent assumes any responsibility for their correctness. The Trustee makes no representations as to the validity or sufficiency of this Indenture or of the Securities, except that the
Trustee represents that it is duly authorized to execute and deliver this Indenture, authenticate the Securities and perform its obligations hereunder and that the statements made by it in a Statement of Eligibility on Form T-1 supplied to the
Company are true and accurate, subject to the qualifications set forth therein. Neither the Trustee nor any Authenticating Agent shall be accountable for the use or application by the Company of Securities or the proceeds thereof, and neither the
Trustee nor any Authenticating Agent shall be responsible for any statement of the Company in any document issued in connection with the sale of the Securities. 

Section 5.04 May Hold Securities. 

The Trustee, any Paying Agent, Security Registrar, Authenticating Agent, Conversion Agent, Redemption Agent or any other agent of the Company,
in its individual or any other capacity, may become the owner of Securities and, subject to Sections 310(b) and 311 of the Trust Indenture Act, may otherwise deal with the Company with the same rights it would have if it were not Trustee, Paying
Agent, Security Registrar, Authenticating Agent, Conversion Agent, Redemption Agent or such other agent. 
 Section 5.05 Compensation and
Reimbursement and Indemnification of Trustee. 
 The Company agrees: 

(1) To pay to the Trustee or any predecessor Trustee from time to time such reasonable compensation for all services rendered by it hereunder
as has been agreed upon from time to time in writing (which compensation shall not be limited by any provision of law in regard to the compensation of a trustee of an express trust); 

  
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 (2) Except as otherwise expressly provided herein, to reimburse each of the Trustee and any
predecessor Trustee upon its request for all reasonable and documented expenses, disbursements and advances incurred or made by the Trustee or any predecessor Trustee in accordance with any provision of this Indenture (including the reasonable
compensation and the expenses and disbursements of its agents and counsel), except any such expense, disbursement or advance as may be attributable to its negligence, bad faith or willful misconduct; and 

(3) To indemnify each of the Trustee or any predecessor Trustee for, and to hold it harmless against, any loss, liability or expense incurred
without negligence, bad faith or willful misconduct on its own part, arising out of or in connection with the acceptance or administration of the trust or trusts hereunder, including the costs and expenses (including the reasonable compensation and
the expenses and disbursements of its agents and counsel) of defending itself against any claim or liability in connection with the exercise or performance of any of its powers or duties hereunder. 

As security for the performance of the obligations of the Company under this Section 5.05, the Trustee shall have a claim prior to the
Securities upon all property and funds held or collected by the Trustee as such, except funds held in trust for the payment of principal of particular Securities. 

When the Trustee incurs expenses or renders services after an Event of Default specified in Section 4.01 occurs, the expenses and
compensation for such services are intended to constitute expenses of administration under any Bankruptcy Law. 
 The provisions of this
Section 5.05 shall survive the resignation or removal of the Trustee and the satisfaction, termination or discharge of this Indenture. 

Section 5.06 Corporate Trustee Required; Eligibility. 

There shall at all times be a Trustee hereunder which shall be eligible to act as Trustee under Section 310(a)(1) of the Trust Indenture
Act and shall have a combined capital and surplus of at least $10 million. If such corporation publishes reports of condition at least annually, pursuant to law or to the requirements of any Federal, state, territorial or District of Columbia
supervising or examining authority, then for the purposes of this Section 5.06, the combined capital and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so
published. If at any time the Trustee shall cease to be eligible in accordance with the provisions of this Section 5.06, it shall resign immediately in the manner and with the effect hereinafter specified in this Article Five. 

Section 5.07 Disqualification; Conflicting Interests. 

If the Trustee has or shall acquire a conflicting interest within the meaning of the Trust Indenture Act, the Trustee shall either eliminate
such interest or resign, to the extent and in the manner provided by, and subject to the provisions of, the Trust Indenture Act and this Indenture. 

  
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 Section 5.08 Resignation and Removal; Appointment of Successor. 

(a) No resignation or removal of the Trustee and no appointment of a successor Trustee pursuant to this Article Five shall become effective
until the acceptance of appointment by the successor Trustee in accordance with the applicable requirements of Section 5.09 and any and all amounts then due and owing to the Trustee hereunder have been paid in full. 

(b) The Trustee may resign at any time by giving written notice thereof to the Company. 

(c) The Trustee may be removed at any time by (i) the Company, by an Officers’ Certificate delivered to the Trustee, provided that
contemporaneously therewith (x) the Company immediately appoints a successor Trustee meeting the requirements of Section 5.06 hereof and (y) the terms of Section 5.09 hereof are complied with in respect of such appointment (the
Trustee being removed hereby agreeing to execute the instrument contemplated by Section 5.09(b) hereof, if applicable, under such circumstances) and provided further that no Default shall have occurred and then be continuing at such time, or
(ii) Act of the Holders of a majority in principal amount of the Outstanding Securities delivered to the Trustee and to the Company. 

(d) If at any time: 
  

	 	1.	the Trustee shall fail to comply with the provisions of Section 310(b) of the Trust Indenture Act after written request therefore by the Company or by any Holder of a Security who has been a bona fide Holder of a
Security for at least six months; 

  

	 	2.	the Trustee shall cease to be eligible under Section 5.06 and shall fail to resign after written request therefore by the Company or by any Holder of a Security who has been a bona fide Holder of a Security for at
least six months; or 

  

	 	3.	the Trustee shall become incapable of acting or shall be adjudged a bankrupt or insolvent or a receiver of the Trustee or of its property shall be appointed or any public officer shall take charge or control of the
Trustee or of its property or affairs for the purpose of rehabilitation, conservation or liquidation; 

 then, in any such
case, (i) the Company by or pursuant to a Board Resolution may remove the Trustee and appoint a successor Trustee, or (ii) subject to Section 315(e) of the Trust Indenture Act, any Holder of a Security who has been a bona fide Holder
of a Security for at least six months may, on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 

(e) If an instrument of acceptance by a successor Trustee shall not have been delivered to the Trustee within 30 days after the giving of a
notice of resignation or the delivery of an Act of removal, the Trustee resigning or being removed may petition any court of competent jurisdiction for the appointment of a successor Trustee. 

  
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 (f) If the Trustee shall resign, be removed or become incapable of acting for any cause, the
Company, by or pursuant to a Board Resolution, shall promptly appoint a successor Trustee. If no successor Trustee shall have been so appointed by the Company and accepted appointment in the manner hereinafter provided within 90 days, any Holder who
has been a bona fide Holder for at least six months may, on behalf of himself and all others similarly situated, petition any court of competent jurisdiction for the appointment of a successor Trustee. 

(g) All retiring Trustees must provide the Successor Trustee with all applicable books and records relating to the performance of the role of
Trustee. 
 (h) The Company shall give notice of each resignation and each removal of the Trustee and each appointment of a successor
Trustee in the manner provided for notices to the Holders in Section 1.06. Each notice shall include the name of the successor Trustee and the address of its Corporate Trust Office. 

Section 5.09 Acceptance of Appointment by Successor. 

(a) In case of the appointment hereunder of a successor Trustee, every such successor Trustee shall execute, acknowledge and deliver to the
Company and to the retiring Trustee an instrument accepting such appointment, and thereupon the resignation or removal of the retiring Trustee shall become effective and such successor Trustee, without any further act, deed or conveyance, shall
become vested with all the rights, powers, trusts and duties of the retiring Trustee; provided, however, that on request of the Company or the successor Trustee, such retiring Trustee shall, upon payment of its charges, execute and deliver an
instrument transferring to such successor Trustee all the rights, powers and trusts of the retiring Trustee, and shall duly assign, transfer and deliver to such successor Trustee all property and money held by such retiring Trustee hereunder,
subject nevertheless to its claim, if any, provided for in Section 5.05. 
 (b) Upon request of any such successor Trustee, the Company
shall execute any and all instruments for more fully and certainly vesting in and confirming to such successor Trustee all such rights, powers and trusts referred to in paragraph (a) of this Section 5.09, as the case may be. 

(c) No successor Trustee shall accept its appointment unless at the time of such acceptance such successor Trustee shall be qualified and
eligible under this Article Five. 
 Section 5.10 Merger, Conversion, Consolidation or Succession to Business. 

Any corporation or other entity into which the Trustee may be merged or converted or with which it may be consolidated, or any corporation or
other entity resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any corporation or other entity succeeding to all or substantially all of the corporate trust business of the Trustee, shall be the
successor of the Trustee hereunder, provided such corporation or entity shall be otherwise qualified and eligible under this Article Five, without the execution or filing of any paper or any further act on the part of any of the parties hereto. In
case any Securities shall have been authenticated, but not delivered, by the Trustee then in office, any successor by merger, 

  
 33 

 
conversion or consolidation to such authenticating Trustee may adopt such authentication and deliver the Securities so authenticated with the same effect as if such successor Trustee had itself
authenticated such Securities. In case any Securities shall not have been authenticated by such predecessor Trustee, any such successor Trustee may authenticate and deliver such Securities, in either its own name or that of its predecessor Trustee,
with the full force and effect which this Indenture provides for the certificate of authentication of the Trustee; provided, however, that the right to adopt the certificate of authentication of any predecessor Trustee or to authenticate
Securities in the name of any predecessor Trustee shall apply only to its successor or successors by merger, conversion or consolidation. 

Section 5.11 Appointment of Authenticating Agent. 

At any time when any of the Securities remain Outstanding, the Trustee may appoint an Authenticating Agent or Agents acceptable to the Company
which shall be authorized to act on behalf of the Trustee to authenticate Securities issued upon original issue or upon exchange, registration of transfer or partial redemption or partial conversion thereof, and Securities so authenticated shall be
entitled to the benefits of this Indenture and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder. Any such appointment shall be evidenced by an instrument in writing signed by a Responsible Officer of the
Trustee, a copy of which instrument shall be promptly furnished to the Company. Wherever reference is made in this Indenture to the authentication and delivery of Securities by the Trustee or the Trustee’s certificate of authentication, such
reference shall be deemed to include authentication and delivery on behalf of the Trustee by an Authenticating Agent and a certificate of authentication executed on behalf of the Trustee by an Authenticating Agent. Each Authenticating Agent shall be
acceptable to the Company and shall at all times be a bank or trust company or corporation organized and doing business and in good standing under the laws of the United States of America or of any state or the District of Columbia, authorized under
such laws to act as Authenticating Agent, having a combined capital and surplus of not less than $10 million and subject to supervision or examination by Federal or state authorities. If such Authenticating Agent publishes reports of condition at
least annually, pursuant to law or the requirements of the aforesaid supervising or examining authority, then for the purposes of this Section 5.11, the combined capital and surplus of such Authenticating Agent shall be deemed to be its
combined capital and surplus as set forth in its most recent report of condition so published. In case at any time an Authenticating Agent shall cease to be eligible in accordance with the provisions of this Section 5.11, such Authenticating
Agent shall resign immediately in the manner and with the effect specified in this Section 5.11. 
 Any corporation or other entity
into which an Authenticating Agent may be merged or converted or with which it may be consolidated, or any corporation or other entity resulting from any merger, conversion or consolidation to which such Authenticating Agent shall be a party, or any
corporation succeeding to the corporate agency or corporate trust business of an Authenticating Agent, shall continue to be an Authenticating Agent, provided such corporation or entity shall be otherwise eligible under this Section 5.11,
without the execution or filing of any paper or further act on the part of the Trustee or the Authenticating Agent. 
 An Authenticating
Agent may at any time resign by giving written notice of resignation to the Trustee and to the Company. The Trustee may at any time terminate the agency of an 

  
 34 

 
Authenticating Agent by giving written notice of termination to such Authenticating Agent and to the Company. Upon receiving such a notice of resignation or upon such a termination, or in case at
any time such Authenticating Agent shall cease to be eligible in accordance with the provisions of this Section 5.11, the Trustee may appoint a successor Authenticating Agent which shall be acceptable to the Company and shall promptly give
written notice of such appointment to all Holders. Any successor Authenticating Agent upon acceptance of its appointment hereunder shall become vested with all the rights, powers and duties of its predecessor hereunder, with like effect as if
originally named as an Authenticating Agent herein. No successor Authenticating Agent shall be appointed unless eligible under the provisions of this Section 5.11. 

The Company agrees to pay to each Authenticating Agent from time to time reasonable compensation including reimbursement of its reasonable and
documented expenses for its services under this Section 5.11. 
 If an appointment is made pursuant to this Section 5.11, the
Securities may have endorsed thereon, in addition to or in lieu of the Trustee’s certificate of authentication, an alternate certificate of authentication substantially in the following form: 

This is one of the Securities referred to in the within-mentioned Indenture. 

 

			
	AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee
		
	By:	 	  

		 	Authenticating Agent
		
	By:	 	  

		 	Authorized Officer

 If all of the Securities may not be originally issued at one time, and the Trustee does not have an office capable of
authenticating Securities upon original issuance located in a Place of Payment where the Company wishes to have Securities authenticated upon original issuance, the Trustee, if so requested by the Company in writing (which writing need not comply
with Section 1.02 and need not be accompanied by an Opinion of Counsel), shall appoint in accordance with this Section 5.11 an Authenticating Agent having an office in a Place of Payment designated by the Company with respect the
Securities, provided that the terms and conditions of such appointment are acceptable to the Trustee. 
 ARTICLE VI 

HOLDERS’ LISTS AND REPORTS BY TRUSTEE AND COMPANY 

Section 6.01 Disclosure of Names and Addresses of Holders. 

In accordance with Section 312(a) of the Trust Indenture Act, the Company shall furnish or cause to be furnished to the Trustee: 

  
 35 

 (1) semi-annually a list, in each case in such form as the Trustee may reasonably require, of the
names and addresses of Holders as of the applicable date; and 
 (2) at such other times as the Trustee may request in writing, within 30
days after the receipt by the Company of any such request, a list of similar form and content as of a date not more than 15 days prior to the time such list is furnished; 

provided, however, that so long as the Trustee is the Security Registrar no such list shall be required to be furnished. 

Section 6.02 Preservation of Information; Communications to Holders. 

The Trustee shall comply with the obligations imposed upon it pursuant to Section 312 of the Trust Indenture Act. 

Every Holder, by receiving and holding the same, agrees with the Company and the Trustee that neither the Company, the Trustee, any Paying
Agent, the Conversion Agent, the Redemption Agent, the Escrow Agent nor any Security Registrar shall be held accountable by reason of the disclosure of any such information as to the names and addresses of the Holders in accordance with
Section 312 of the Trust Indenture Act, regardless of the source from which such information was derived, and that the Trustee shall not be held accountable by reason of mailing any material pursuant to a request made under Section 312(b)
of the Trust Indenture Act. 
 Section 6.03 Reports by Trustee. 

Within 60 days after May 15 of each year commencing with May 15, 2016, the Trustee, if so required under the Trust Indenture Act,
shall transmit by mail to all Holders of Securities as provided in Section 313(c) of the Trust Indenture Act a brief report dated as of such May 15 which meets the requirements of Section 313(a) of the Trust Indenture Act. 

A copy of each such report shall, at the time of such transmission to Holders, be filed by the Trustee with each stock exchange, if any, upon
which the Securities are listed, with the Commission and with the Company. The Company will promptly notify the Trustee of the listing of the Securities on any stock exchange. The Trustee also will comply with Section 313(b)(2) of the Trust
Indenture Act. 
 Section 6.04 Reports by Company. 

The Company shall file with the Trustee within 30 days after the Company is required to file the same with the Commission, copies of the annual
reports and information, documents and other reports (or copies of such portions of the foregoing as the Commission may prescribe) which the Company is required to file with the Commission pursuant to Section 13 or 15(d) of the Exchange Act. If
the Company is not required to file information, documents or reports pursuant to either of those sections, then the Company shall provide to the Trustee such reports as may be prescribed to be filed by the Company by the Commission at such time. To
the extent the Company has filed such information with the Commission through the Commission’s Electronic Data Gathering, Analysis and Retrieval (commonly known as “EDGAR”) system, or any successor system employed by the
Commission, the Company shall be deemed to have complied with this Section 6.04. 

  
 36 

 Delivery of such reports, information and documents to the Trustee is for informational purposes
only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Company’s compliance with any of its covenants hereunder
(as to which the Trustee is entitled to rely exclusively on Officers’ Certificates). 
 Section 6.05 Preferential Collection of Claims Against
Company. 
 The Trustee is subject to Section 311(a) of the Trust Indenture Act, excluding any creditor relationship listed in
Section 311(b) of the Trust Indenture Act. A Trustee who has resigned or been removed shall be subject to Section 311(a) of the Trust Indenture Act to the extent indicated therein. 

ARTICLE VII 

CONSOLIDATION, MERGER, CONVEYANCE OR TRANSFER 

Section 7.01 Company May Consolidate, Etc., Only on Certain Terms. 

The Company shall not consolidate with or merge with or into any other corporation or convey or transfer its properties and assets
substantially as an entirety to any Person, unless: 
 (1) the successor entity which shall be a Corporation organized and existing under
the laws of any state of the United States of America or the District of Columbia, any country comprising the European Union, the United Kingdom or Japan shall expressly assume, by an indenture supplemental hereto executed by the successor Person
and delivered to the Trustee, the due and punctual payment of the principal of all the Securities and the performance of every obligation in this Indenture and the Outstanding Securities on the part of the Company to be performed or observed and
shall provide for conversion rights in accordance with the provisions of the Indenture and the Securities and if any such successor entity is not subject to the jurisdiction of any state of the United States of America or the District of Columbia,
such entity submits to jurisdiction for all purposes with respect to the Securities and appoints an agent for service of process in the United States of America; 

(2) immediately after giving effect to such transaction or series of transactions, no Event of Default or event which, after notice or lapse
of time, or both, would become an Event of Default, shall have occurred and be continuing; and 
 (3) either the Company or the successor
Person shall have delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that such consolidation, merger, conveyance, transfer or lease and, if a supplemental indenture is required in connection with such
transaction, such supplemental indenture comply with this Article Seven and that all conditions precedent herein provided for relating to such transaction have been complied with. 

  
 37 

 Notwithstanding the foregoing, the Company may consolidate with, or merge with or into, an
Affiliate incorporated for the purpose of incorporating in another jurisdiction of the United States of America or any state thereof or the District of Columbia without complying with the requirement of paragraph (2) above. 

Notwithstanding the foregoing, subject to compliance with Section 9.07 and the terms of the Escrow Agreement, the Company may convey,
transfer or lease all or substantially all of its properties and assets as an entirety to any Subsidiary or Subsidiaries, in one transaction or a series of related transactions and the transfer by the Company, in a single transaction or series of
transactions, of all or substantially all of its cash, cash equivalents and marketable securities of non-Affiliates for which the Company receives fair market value, as determined by its Board of Directors, will not constitute a sale of all or
substantially all of the Company’s assets. 
 For purposes of this Section, the sale, lease, conveyance, assignment, transfer, or other
disposition of all or substantially all of the properties and assets of one or more Subsidiaries, which property and assets, if held by the Company instead of such Subsidiaries, would constitute all or substantially all of the properties and assets
of the Company on a consolidated basis, shall be deemed to be the transfer of all or substantially all of the properties and assets of the Company. 

Section 7.02 Successor Person Substituted. 

Upon any consolidation or merger, or any conveyance or transfer of the properties and assets of the Company substantially as an entirety in
accordance with Section 7.01, the successor corporation formed by such consolidation or into which the Company is merged, or the successor Person to which such conveyance or transfer is made, shall succeed to, and be substituted for, and may
exercise every right and power of, the Company under this Indenture with the same effect as if such successor had been named as the Company herein; and in the event of any such conveyance or transfer, except in the case of a lease to another Person,
the Company shall be discharged from all obligations and covenants under this Indenture and the Securities. 
 ARTICLE VIII 

SUPPLEMENTAL INDENTURES 

Section 8.01 Supplemental Indentures Without Consent of Holders. 

Without the consent of any Holders of Securities, the Company, when authorized by or pursuant to a Board Resolution, and the Trustee, at any
time and from time to time, may enter into one or more indentures supplemental hereto, in form reasonably satisfactory to the Trustee, for any of the following purposes: 

(1) to evidence the succession of another Person to the Company and the assumption by any such successor of the covenants of the Company
herein and in the Securities; 
 (2) to add to the covenants of the Company for the benefit of the Holders or to surrender any right or
power herein conferred upon the Company; 

  
 38 

 (3) to add any additional Events of Default for the benefit of the Holders; provided,
however, that in respect of any such additional Events of Default such supplemental indenture may provide for a particular period of grace after default (which period may be shorter or longer than that allowed in the case of other Defaults) or
may provide for an immediate enforcement upon such Default or may limit the remedies available to the Trustee upon such Default or may limit the right of the Holders of a majority in aggregate principal amount of the Securities to which such
additional Events of Default apply to waive such default;  
 (4) to evidence and provide for the acceptance of appointment hereunder
by a successor Trustee with respect to the Securities; or 
 (5) to cure any ambiguity, to correct or supplement any provision herein
which may be inconsistent with any other provision herein, or to make any other provisions with respect to matters or questions arising under this Indenture; provided that such action shall not adversely affect the interests of the Holders in
any material respect.  
 Section 8.02 Supplemental Indentures with Consent of Holders. 

With the consent of the Holders of not less than a majority in aggregate principal amount of all Outstanding Securities, by Act of said Holders
delivered to the Company and the Trustee, the Company, when authorized by or pursuant to a Board Resolution, and the Trustee may enter into an indenture or indentures supplemental hereto for the purpose of adding any provisions to or changing in any
manner or eliminating any of the provisions of this Indenture which affects the Securities or of modifying in any manner the rights of the Holders of Securities under this Indenture; provided, however, that no such supplemental indenture
shall, without the consent of the Holder of each Outstanding Security affected thereby: 
 (1) change the Stated Maturity Date of the
Securities, reduce the principal amount of the Securities, reduce the amount thereof provable in bankruptcy pursuant to Section 4.04, change the currency of payment or Place of Payment where any Security or any principal of is payable, impair
the right to institute suit for the enforcement of any such payment on or after the Stated Maturity Date thereof or adversely affect any right to convert any Security as may be provided herein; 

(2) reduce the percentage in principal amount of the Outstanding Securities, the consent of whose Holders is required for any such
supplemental indenture, or the consent of whose Holders is required for any waiver (of compliance with certain provisions of this Indenture or certain defaults hereunder and their consequences) provided for in this Indenture, or reduce the
requirements for quorum or voting; or 
 (3) modify any of the provisions of Section 4.13 or this Section 8.02, except to
increase any such percentage or to provide that certain other provisions of this Indenture cannot be modified or waived without the consent of the Holder of each Outstanding Security affected thereby; provided, however, that this clause shall
not be deemed to require the consent of any Holder with respect to changes in the references to “the Trustee” and concomitant changes in this Section 8.02, or the deletion of this proviso, in accordance with the requirements of
Section 8.01(6).  

  
 39 

 It shall not be necessary for any Act of Holders under this Section 8.02 to approve the
particular form of any proposed supplemental indenture, but it shall be sufficient if such Act shall approve the substance thereof. 
 The
Company may, but shall not be obligated to, fix a record date for the purpose of determining the Persons entitled to consent to any indenture supplemental hereto. If a record date is fixed, the Holders on such record date, or their duly designated
proxies, and only such Persons, shall be entitled to consent to such supplemental indenture, whether or not such Holders remain Holders after such record date; provided, that unless such consent shall have become effective by virtue of the
requisite percentage having been obtained prior to the date which is 90 days after such record date, any such consent previously given shall automatically and without further action by any Holder be cancelled and of no further effect. 

Section 8.03 Execution of Supplemental Indentures. 

In executing, or accepting the additional trusts created by, any supplemental indenture permitted by this Article Eight or the modification
thereby of the trusts created by this Indenture, the Trustee shall be entitled to receive, and shall be fully protected in relying upon, in addition to the documents required by Section 1.02 of this Indenture, an Opinion of Counsel stating that
the execution of such supplemental indenture is authorized or permitted by this Indenture. The Trustee may, but shall not be obligated to, enter into any such supplemental indenture which affects the Trustee’s own rights, duties or immunities
under this Indenture or otherwise. 
 Section 8.04 Effect of Supplemental Indentures. 

Upon the execution of any supplemental indenture under this Article Eight, this Indenture shall be modified in accordance therewith, and such
supplemental indenture shall form a part of this Indenture for all purposes; and every Holder theretofore or thereafter authenticated and delivered hereunder shall be bound thereby. 

Section 8.05 Conformity with Trust Indenture Act. 

Every supplemental indenture executed pursuant to this Article Eight shall conform to the requirements of the Trust Indenture Act as then in
effect. 
 Section 8.06 Reference in Securities to Supplemental Indentures. 

Securities authenticated and delivered after the execution of any supplemental indenture pursuant to this Article Eight may, and shall, if
required by the Trustee, bear a notation in form approved by the Trustee as to any matter provided for in such supplemental indenture. If the Company shall so determine, new Securities so modified as to conform, in the opinion of the Trustee and the
Company, to any such supplemental indenture may be prepared and executed by the Company and authenticated and delivered by the Trustee in exchange for Outstanding Securities. 

  
 40 

 ARTICLE IX 

COVENANTS 
 Section 9.01 Payment
of Principal. 
 The Company covenants and agrees for the benefit of the Holders that it will duly and punctually pay the principal of
the Securities in accordance with the terms of the Securities and this Indenture. 
 Section 9.02 Maintenance of Office or Agency. 

The Company shall maintain in each Place of Payment an office or agency where Securities may be presented or surrendered for payment, where
Securities may be surrendered for registration of transfer, where Securities may be surrendered for conversion and where notices and demands to or upon the Company in respect of the Securities and this Indenture may be served. The Company will give
prompt written notice to the Trustee of the location, and any change in the location, of each such office or agency. If at any time the Company shall fail to maintain any such required office or agency in respect of the Securities or shall fail to
furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the same as its agent to receive such respective
presentations, surrenders, notices and demands, and the Company hereby appoints the Trustee its agent to receive all such presentations, surrenders, notices and demands. 

The Company may also from time to time designate one or more other offices or agencies where the Securities may be presented or surrendered
for any or all of such purposes, and may from time to time rescind such designations; provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligation to maintain an office or agency in
accordance with the requirements set forth above for Securities for such purposes. The Company will give prompt written notice to the Trustee of any such designation or rescission and of any change in the location of any such other office or agency.
The Company hereby designates as a Place of Payment the office or agency of the Corporate Trust Office, and initially appoints the Trustee at its Corporate Trust Office and as its agent to receive all such presentations, surrenders, notices and
demands. 
 Section 9.03 Money for Securities Payments to Be Held in Escrow. 

The Company will, on or before the Issuance Date, deposit with the Escrow Agent in accordance with the Escrow Agreement (a copy of which is
attached as hereto as Exhibit C), a sum sufficient to pay the principal of the Securities, such sum of money to be held in escrow for the benefit of the Persons entitled to such principal of such Security. 

Notwithstanding the preceding paragraph, any money deposited with the Trustee or any Paying Agent in trust for the payment of the principal on
any Security not converted in accordance with Article Ten hereof or not redeemed in accordance with Article Eleven hereof and remaining unclaimed for six months after the Stated Maturity Date shall be paid to the Company upon Company Request; and
the Holder of such Security shall thereafter, as an unsecured general creditor, look only to the Company for payment thereof, and all liability of the Trustee or such Paying Agent with respect to such money held in trust, shall thereupon cease. 

  
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 Section 9.04 Statement as to Compliance. 

The Company will deliver to the Trustee, within 120 days after the end of each fiscal year ending after the date hereof so long as any Security
is Outstanding hereunder, a brief certificate from the principal executive officer or principal financial officer of the Company as to his or her knowledge of the Company’s compliance with all conditions and covenants under this Indenture. For
purposes of this Section 9.04, such compliance shall be determined without regard to any period of grace or requirement of notice under this Indenture. 

Section 9.05 Corporate Existence. 

Subject to Article Seven, the Company shall do or cause to be done all things necessary to preserve and keep in full force and effect the
corporate existence and related rights and franchises (charter and statutory) of the Company. 
 Section 9.06 Reports to Holders. 

Within 45 days following the end of each fiscal quarter in which the Securities are outstanding, the Company shall furnish to Holders a
statement setting forth the principal amount of the Outstanding Securities at the close of such fiscal quarter. 
 Section 9.07 Liens. 

The Company shall not, and shall cause each Subsidiary not to create, purport to create or suffer to exist any Lien upon the Property. 

Section 9.08 Escrow Agreement. 
 (1)
Concurrent with the initial issuance of the Securities, the Company and the Trustee shall enter into the Escrow Agreement and the Company shall deposit an amount equal to the principal amount of the Securities with the Escrow Agent (such amounts
deposited with the Escrow Agent less amounts attributable to Securities converted in accordance with Article Ten hereof or redeemed in accordance with Article Eleven hereof, the “Property”). In accordance with the terms and conditions of
the Escrow Agreement, the Escrow Agent shall use the Property to pay the principal amount of the Securities on or prior to the Stated Maturity Date in accordance with the terms thereof. 

(2) If any Security is converted pursuant to Article Ten, the portion of the Property corresponding to the principal amount of such Security
shall be returned to the Company in accordance with the terms of the Escrow Agreement. 
 (3) The Trustee and each of the Holders
acknowledge that a release of the Property in accordance with the provisions of the Escrow Agreement and of this Indenture will not be deemed for any purpose to be an impairment of the Property in contradiction of the terms of this Indenture or the
Trust Indenture Act. 

  
 42 

 Section 9.09 Treatment of Escrow Funds. 

The Company shall not, and shall cause each Subsidiary not to treat the Escrow Funds as an asset on the books and records of the Company or any
Subsidiary nor account for the Escrow Funds as an asset on the Balance Sheet of the Company or any Subsidiary. 
 ARTICLE X 

CONVERSION 
 Section 10.01
Conversion of Securities. 
 (1) Right to Convert. 

(a) Subject to the procedures for conversion set forth in this Article Ten, a Holder may convert its Securities prior to the close of business
on the final Business Day of each calendar month (each such date, as such date may be delayed in accordance with Section 10.02(3), a “Conversion Date”) into the number of shares of Common Stock equal to the principal amount of
such Security being converted multiplied by the Conversion Rate in effect at such time, in a minimum amount of $50,000 per conversion (or such Holder’s entire principal amount of Securities held, if less). 

(b) If the Company is a party to an Alternate Reorganization Event, a Holder may surrender Securities for conversion at any time, after the
Company gives the notice referred to in the last sentence of this Section 10.01(1)(b), from and after the 15th Trading Day prior to the anticipated effective date of such transaction or event until the Business Day that is immediately prior to
the effective date of such transaction. The Company shall notify, in the manner provided for in Sections 1.05 and 1.06, as applicable, each of the Holders and the Trustee of the Alternate Reorganization Event no later than 15 Trading Days prior to
the anticipated effective date of the Alternate Reorganization Event. 
 (2) Conversion Procedures. The following procedures
shall apply to conversions of Securities: 
 (a) In respect of a Definitive Security, a Holder must (A) complete and manually sign the
conversion notice on the back of the Security, or a facsimile of such conversion notice; (B) deliver such conversion notice, which is irrevocable, and the Security to the Conversion Agent on or prior to the applicable Conversion Date;
(C) if required, furnish appropriate endorsements and transfer documents as may be required by the Conversion Agent and, if required pursuant to Section 10.01(4) below, pay all transfer or similar taxes; and (D) if required pursuant
to Section 3.11, pay funds equal to the amount of applicable withholding taxes; and 
 (b) In respect of a beneficial interest in a
Global Security, a Beneficial Owner must comply with the Depositary’s procedures for converting a beneficial interest in a Global Security and, if required pursuant to Section 3.11, pay funds equal to the amount of applicable withholding
taxes, and if required, pay all taxes or duties required pursuant to Section 10.01(4) below, if any. 

  
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 (3) Issuance of Shares. Within 5 Business Days of each Conversion Date, the
Company shall issue the number of whole shares of Common Stock issuable upon conversion, with any fractional shares (after aggregating all Securities being converted by a Holder on such date) rounded down to the nearest whole share of Common Stock.
No Holder shall have any rights with respect to Common Stock issuable upon conversion of Securities until the Conversion Date with respect to such shares of Common Stock. 

(4) Taxes on Conversion. If a Holder converts Securities, the Company shall pay any documentary, stamp or similar issue
or transfer tax due on the issue of shares of Common Stock upon the conversion. However, the Holder shall pay any such tax which is due because the Holder requests the shares to be issued in a name other than the Holder’s name. The Conversion
Agent may refuse to deliver the certificates representing the Common Stock being issued in a name other than the Holder’s name until the Conversion Agent receives a sum sufficient to pay any tax which shall be due because the shares are to be
issued in a name other than the Holder’s name, but the Conversion Agent shall have no duty to determine if any such tax is due. Nothing herein shall preclude any withholding of tax required by law. 

(5) Certain Covenants of the Company.  

(a) The Company shall, prior to issuance of any Securities hereunder, and from time to time as may be necessary prior to the Stated Maturity
Date, reserve out of its authorized but unissued Common Stock or shares of Common Stock held in treasury, sufficient number of shares of Common Stock, free of preemptive rights, to permit the conversion of the Securities. 

(b) All shares of Common Stock delivered upon conversion of the Securities shall be newly issued shares or treasury shares, shall be duly and
validly issued and fully paid and nonassessable and shall be free from preemptive rights and free of any lien or adverse claim. 
 (c) The
Company shall endeavor promptly to comply with all federal and state securities laws regulating the issuance and delivery of shares of Common Stock upon the conversion of Securities, if any. 

Section 10.02 Adjustments to Conversion Rate. 

The Conversion Rate shall be adjusted from time to time (successively and for each event described) by the Company as follows: 

(1) If the Company shall, at any time or from time to time while any of the Securities are outstanding, issue shares of Common Stock as a
dividend or distribution on shares of Common Stock, or if the Company effects a share split or share combination in respect of the Common Stock, then the Conversion Rate shall be adjusted based on the following formula: 

 
 

 

  
 44 

 where 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such dividend or distribution, or, if no Record Date, immediately prior to the effective date of such share split or share
combination, as applicable;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Close of Business on the Record Date for such dividend or distribution, or, if no Record Date, immediately prior to the effective date of such share split or share
combination, as applicable;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the Close of Business on the Record Date for such dividend or distribution, or, if no Record Date, immediately prior to the effective date of such share split
or share combination, as applicable; and
			
	OS’	  	=	  	the number of shares of Common Stock outstanding immediately after such dividend or distribution, or, if no Record Date, immediately after the Close of Business on the effective date of such share split or share combination, as
applicable.

 Such adjustment shall become effective immediately after the Close of Business on the Record Date fixed for
such dividend or distribution, or, if no Record Date, immediately prior to the opening of business on the effective date for such share split or share combination. If any dividend or distribution of the type described in this Section 10.02(1)
is declared but not so paid or made, or the outstanding shares of Common Stock are not split or combined, as the case may be, the Conversion Rate shall be immediately readjusted, effective as of the date the Board of Directors determines not to pay
such dividend or distribution, or split or combine the outstanding shares of Common Stock, as the case may be, to the Conversion Rate that would then be in effect if such dividend, distribution, share split or share combination had not been
declared. 
 The Company shall not pay any dividend or make any distribution on shares of Common Stock held in treasury by the Company. 

(2) Except as otherwise provided for by Section 10.02(3) below, if the Company shall, at any time or from time to time while any of the
Securities are outstanding, distribute to all or substantially all holders of its outstanding shares of Common Stock any options, rights or warrants entitling them for a period of not more than 45 calendar days from the Record Date of such
distribution to subscribe for or purchase shares of Common Stock at a price per share less than the Closing Price of the Common Stock on the Trading Day immediately preceding the Record Date of such distribution, the Conversion Rate shall be
adjusted based on the following formula: 
  
 

 
 where 

  
 45 

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such distribution;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Close of Business on the Record Date for such distribution;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the Close of Business on the Record Date for such distribution;
			
	X	  	=	  	the total number of shares of Common Stock issuable pursuant to such options, rights or warrants; and
			
	Y	  	=	  	the number of shares of Common Stock equal to the aggregate price payable to exercise such options, rights or warrants divided by the average Closing Price of the Common Stock over the 10 consecutive Trading Day period ending on
the Record Date.

 Such adjustment shall be successively made whenever any such options, rights or warrants are distributed and
shall become effective immediately after the Close of Business on the record date for such distribution. To the extent that shares of Common Stock are not delivered pursuant to any such options, rights or warrants that are non-transferable upon the
expiration or termination of such options, rights or warrants, the Conversion Rate shall be readjusted to the Conversion Rate that would then be in effect had the adjustments made upon the distribution of such options, rights or warrants been made
on the basis of the delivery of only the number of shares of Common Stock actually delivered. 
 In determining the aggregate price payable
to exercise such options, rights or warrants, there shall be taken into account any amount payable on exercise thereof, with the value of such consideration, if other than cash, to be determined in good faith by the Board of Directors. 

(3) If the Company, at any time or from time to time while any of the Securities are outstanding, shall, by dividend or otherwise, distribute
to all or substantially all holders of its Common Stock shares of any class of Capital Stock of the Company (other than Common Stock as covered by Section 10.02(1)), evidences of its indebtedness, assets, property or rights or warrants to
acquire Capital Stock or other securities, but excluding (i) dividends or distributions as to which an adjustment under Section 10.02(1), Section 10.02(2) or Section 10.02(4) hereof shall apply and (ii) Spin-Offs to which
the provision set forth below in this Section 10.02(3) shall apply (any of such shares of Capital Stock, indebtedness, assets, property or rights or warrants to acquire Common Stock or other securities, hereinafter in this Section 10.02(3)
called the “Distributed Property”), then, in each such case the Conversion Rate shall be adjusted based on the following formula: 
  

 

  
 46 

 where 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the Record Date for such distribution;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Close of Business on the Record Date for such distribution;
			
	SP0	  	=	  	the average Closing Price of the Common Stock over the 10 consecutive Trading Day period ending on the Record Date for such distribution; and
			
	FMV	  	=	  	the fair market value (as determined in good faith by the Board of Directors) of the portion of Distributed Property with respect to each outstanding share of Common Stock on the Record Date for such distribution.

 Such adjustment shall become effective immediately after the Close of Business on the Record Date for such
distribution; provided that if “FMV” as set forth above is equal to or greater than SP0 as set forth above, then in lieu of the foregoing adjustment, the Company shall
distribute to each holder of Securities on the date such Distributed Property is distributed to holders of Common Stock, but without requiring such holder to convert its Securities, the amount of Distributed Property such holder would have received
had such holder owned a number of shares of Common Stock equal to the product of (a) the Conversion Rate on the Record Date fixed for determination for shareholders entitled to receive such distribution and (b) the principal amount of such
capitalized Security. If the Board of Directors determines “FMV” for purposes of this Section 10.02(3) by reference to the actual or when issued trading market for any securities, it shall in doing so consider the prices in such
market over the same period used in computing the average Closing Price of the Common Stock for purposes of calculating SP0 in the formula in this Section 10.02(3). 

With respect to an adjustment pursuant to this Section 10.02(3) where there has been a payment of a dividend or other distribution on the
Common Stock consisting of shares of Capital Stock of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit of the Company (a “Spin-Off”), the Conversion Rate in effect immediately
before the Close of Business on the 10th Trading Day immediately following, and including, the effective date of the Spin-Off shall be increased based on the following formula: 

 
 

 
 where 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the 10th Trading Day immediately following the effective date of the Spin-Off;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Close of Business on the 10th Trading Day immediately following the effective date of the Spin-Off;

  
 47 

					
			
	FMV	  	=	  	the average of the Closing Prices of the Capital Stock or similar equity interest distributed to holders of Common Stock applicable to one share of Common Stock over the 10 consecutive Trading Day period immediately following,
and including, the effective date of the Spin-Off; and
			
	MP0	  	=	  	the average Closing Price of the Common Stock over the 10 consecutive Trading Day period calculated immediately following, and including, the effective date of the Spin-Off.

 Such adjustment shall occur on the 10th Trading Day from,
and including, the effective date of the Spin-Off. In the event that a Conversion Date occurs within the 10 Trading Days from, and including, the effective date of the Spin-Off, such Conversion Date shall be delayed until the conclusion of such 10
Trading Day period without further action by the Company. 
 For purposes of this Section 10.02(3), Section 10.02(1) and
Section 10.02(2) hereof, any dividend or distribution to which this Section 10.02(3) is applicable that also includes shares of Common Stock to which Section 10.02(1) hereof applies, or rights or warrants to subscribe for or purchase
shares of Common Stock to which Section 10.02(1) or 10.02(2) hereof applies (or both), shall be deemed instead to be (i) a dividend or distribution of the evidences of indebtedness, assets or shares of Capital Stock other than such shares
of Common Stock or rights or warrants to which Section 10.02(1) or 10.02(2) hereof applies (and any Conversion Rate adjustment required by this Section 10.02(3) with respect to such dividend or distribution shall then be made) immediately
followed by (ii) a dividend or distribution of such shares of Common Stock or such options, rights or warrants to which Section 10.02(1) or 10.02(2) hereof applies (and any further Conversion Rate adjustment required by
Section 10.02(1) and 10.02(2) hereof with respect to such dividend or distribution shall then be made), except (A) the Close of Business on the Record Date of such dividend or distribution shall be substituted for “the Close of
Business on the Record Date,” “the Close of Business on the Record Date or the effective date,” “after the Close of Business on the Record Date for such dividend or distribution or the effective date of such share split or share
combination” and “the Close of Business on the Record Date for such distribution” within the meaning of Section 10.02(1) and Section 10.02(2) hereof and (B) any shares of Common Stock included in such dividend or
distribution shall not be deemed “outstanding immediately prior to the Close of Business on the Record Date or the Close of Business on the effective date” within the meaning of Section 10.02(1) hereof. 

(4) In case the Company shall pay dividends or make distributions consisting exclusively of cash to all or substantially all holders of its
Common Stock, the Conversion Rate shall be adjusted based on the following formula: 
  
 

 
 Where 

  
 48 

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Record Date for such distribution;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Record Date for such distribution;
			
	SP0	  	=	  	the Closing Price of Common Stock on the Trading Day immediately preceding the Record Date for such distribution; and
			
	C	  	=	  	the amount in cash per share distributed to holders of Common Stock in such distribution.

 Such adjustment shall become effective immediately prior to the opening of business on the Record Date for
such dividend or distribution; provided that if the portion of the cash so distributed applicable to one share of the Common Stock is equal to or greater than SP0 as set forth above, in
lieu of the foregoing adjustment, adequate provision shall be made so that each Holder of Securities shall receive on the date on which such cash dividend is distributed to holders of Common Stock, the amount of cash such holder would have received
had such holder owned a number of shares equal to the product of (a) Conversion Rate on the Record Date for such distribution and (b) the principal of such Security, without being required to convert the Securities. If such dividend or
distribution is not so paid or made, the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. 

For the avoidance of doubt, for purposes of this subsection (4), in the event of any reclassification of the Common Stock, as a result of
which the Securities become convertible into more than one class of Common Stock, if an adjustment to the Conversion Rate is required pursuant to this subsection (4), references in this Section 10.02 to one share of Common Stock or Closing
Price of one share of Common Stock shall be deemed to refer to a unit or to the price of a unit consisting of the number of shares of each class of Common Stock into which the Securities are then convertible equal to the numbers of shares of such
class issued in respect of one share of Common Stock in such reclassification. The above provisions of this paragraph shall similarly apply to successive reclassifications. 

(5) If the Company makes a payment of cash or other consideration in respect of a tender offer or exchange offer for all or any portion of the
Common Stock, where such cash and the value of any such other consideration included in the payment per share of Common Stock validly tendered or exchanged exceeds the Closing Price of the Common Stock on the Trading Day next succeeding the last
date (the “Expiration Date”) on which tenders or exchanges may be made pursuant to such tender or exchange offer (as it may be amended), the Conversion Rate shall be increased based on the following formula: 

 
 

 

  
 49 

 Where 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the Expiration Date;
			
	CR’	  	=	  	the new Conversion Rate in effect immediately after the Close of Business on the Expiration Date;
			
	AC	  	=	  	the aggregate value of all cash and any other consideration (as determined in good faith by the Board of Directors) paid for shares purchased in such tender or exchange offer;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the date such tender or exchange offer expires;
			
	OS’	  	=	  	the number of shares of Common Stock outstanding immediately after the date such tender or exchange offer expires (after giving effect to such tender offer or exchange offer); and
			
	SP’	  	=	  	the average Closing Price of Common Stock over the ten consecutive Trading Days ending on the Trading Day next succeeding the Expiration Date.

 Such adjustment will be determined at the Close of Business on the tenth Trading Day
immediately following, but excluding, the Expiration Date but will be given effect at the Open of Business on the Trading Day next succeeding the Expiration Date. If the Trading Day next succeeding the Offer Expiration Date is less than 10 Trading
Days prior to, and including, the end of the Conversion Period in respect of any conversion, references within this clause (5) to 10 Trading Days shall be deemed to be replaced, solely in respect of that conversion, with such lesser number of
Trading Days as have elapsed from, and including, the Trading Day next succeeding the Expiration Date to, and including, the last Trading Day of such Conversion Period. In respect of any conversion during the 10 Trading Days commencing on the
Trading Day next succeeding the Offer Expiration Date, references within this clause (5) to 10 Trading Days shall be deemed to be replaced, solely in respect of that conversion, with such lesser number of Trading Days as have elapsed from, and
including, the Trading Day next succeeding the Expiration Date to, but excluding, the relevant Conversion Date. No adjustment pursuant to the above formula will result in a decrease of the Conversion Rate. 

If the Company or Subsidiary is obligated to purchase shares of Common Stock pursuant to any such tender or exchange offer, but the Company or
Subsidiary is permanently prevented by applicable law from effecting any such purchases or all or any portion of such purchases are rescinded, then the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in effect if
such tender or exchange offer had not been made or had only been made in respect of the purchases that were effected. 

  
 50 

 (6) If this Section 10.02 applies to any event or occurrence that is not also a
Reorganization Event, Section 10.03 shall not apply in respect of such event or occurrence. 
 Section 10.03 Effect of Reclassification,
Consolidation, Merger or Sale. 
 (1) If any of the following events occur (any such event or transaction satisfying both
subclauses (a) and (b) of this Section 10.03(1), a “Reorganization Event”): (a) (i) any recapitalization, reclassification or change of Common Stock (other than a subdivision or combination) as a result of
which the Common Stock would be converted into, or exchanged for, stock, other securities, or other property or assets (or any combination thereof), (ii) any statutory share exchange, consolidation or merger involving the Company pursuant to
which the Common Stock will be converted into cash, securities or other property (or any combination thereof), or (iii) any sale, lease or other transfer in one transaction or a series of transactions of all or substantially all of the
consolidated assets of the Company and its Subsidiaries, taken as a whole, to any Person as a result of which the Common Stock will be converted into cash, securities or other property (or any combination thereof) and (b) the equity securities
of the surviving entity are registered with the U.S. Securities and Exchange Commission under the Exchange Act, then the Company or the successor or purchasing Person, as the case may be, shall execute with the Trustee a supplemental indenture
(which shall comply with the Trust Indenture Act as in force at the date of execution of such supplemental indenture) providing that at the effective time of the Reorganization Event each Security shall be convertible into the kind and amount of
shares of stock, other securities or other property or assets (including cash or any combination thereof) that a holder of a number of shares of Common Stock equal to the Conversion Rate immediately prior to such Reorganization Event would have
owned or been entitled to receive upon such Reorganization Event (the “Reference Property”). For purposes of the foregoing, the type and amount of consideration that a holder of Common Stock would have been entitled to receive in
the case of any such Reorganization Event that causes the Common Stock to be converted into the right to receive more than a single type of consideration (determined based in part upon any form of stockholder election) shall be deemed to be the
weighted average of the types and amounts of consideration received by the holders of Common Stock that affirmatively make such an election. Such supplemental indenture shall provide for provisions and adjustments which shall be as nearly equivalent
as may be practicable to the provisions and adjustments provided for in this Article Ten, as determined in good faith by the Company (which determination shall be conclusive and binding), to make such provisions apply to such other Person if
different from the original issuer of the Securities. If, in the case of any Reorganization Event, the cash, securities or other property receivable thereupon by a holder of Common Stock includes cash, securities or other property of a Person other
than the successor or purchasing Person, as the case may be, in such Reorganization Event, then such supplemental indenture shall also be executed by such successor or purchasing Person, as the case may be, and shall contain such additional
provisions to protect the interests of the Holders of the Securities as the Board of Directors shall reasonably consider necessary by reason of the foregoing.  

(2) Following the effective time of any such Reorganization Event, settlement of Securities converted shall be in cash and units of Reference
Property determined in accordance with Section 10.03(1) above based on the Conversion Rate and Current Market Price of such Reference Property. For the purposes of determining such Conversion Rate and Current Market Price, if the Reference
Property includes securities for which the price cannot be determined in a 

  
 51 

 
manner contemplated by the definition of Current Market Price or other property, then the value of such property shall be the fair market value of such property as determined by the Board of
Directors in good faith, and if the Reference Property includes cash, then the value of such cash shall be the amount thereof. 
 (3) The
Company shall cause notice of the execution of any supplemental indenture required by this Section 10.03 to be mailed to each Holder of Securities, at its address appearing on the Securities Register provided for in Section 3.05 of this
Indenture, within 20 calendar days after execution thereof. Failure to deliver such notice shall not affect the legality or validity of such supplemental indenture. 

(4) The above provisions of this Section 10.03 shall similarly apply to successive Reorganization Events. 

(5) If this Section 10.03 applies to any event or occurrence, Section 10.02 shall not apply in respect of such event or occurrence.

 (6) None of the foregoing provisions shall affect the right of a Holder of Securities to convert the Securities into cash and shares of
Common Stock, if applicable, as set forth in Section 10.01 prior to the effective time of such Reorganization Event. 
 (7)
Notwithstanding the foregoing, if any of the following events occur (any such event or transaction satisfying both subclauses (a) and (b) of this Section 10.03(7), an “Alternate Reorganization Event”):
(a) (i) any recapitalization, reclassification or change of Common Stock (other than a subdivision or combination) as a result of which the Common Stock would be converted into, or exchanged for, stock, other securities, or other property
or assets (or any combination thereof), (ii) any statutory share exchange, consolidation or merger involving the Company pursuant to which the Common Stock will be converted into cash, securities or other property (or any combination thereof),
or (iii) any sale, lease or other transfer in one transaction or a series of transactions of all or substantially all of the consolidated assets of the Company and its Subsidiaries, taken as a whole, to any Person as a result of which the
Common Stock will be converted into cash, securities or other property (or any combination thereof) and (b) the equity securities of the surviving entity are not registered with the U.S. Securities and Exchange Commission under the Exchange
Act, then the Company or the successor or purchasing Person, as the case may be, shall execute with the Trustee a supplemental indenture (which shall comply with the Trust Indenture Act as in force at the date of execution of such supplemental
indenture) providing that at the effective time of such event the conversion features in Article Ten shall be eliminated and the principal of any Outstanding Securities shall be due on the Stated Maturity Date.  

Section 10.04 Responsibility of Trustee. 

The Trustee and any other Conversion Agent shall not at any time be under any duty or responsibility to the Company or any Holder of Securities
to determine the Conversion Rate, or whether any facts exist which may require any adjustment of the Conversion Rate, or with respect to the nature or extent or calculation of any such adjustment when made, or with respect to the method employed in
making the same. The Trustee and any other Conversion Agent shall 

  
 52 

 
not be accountable with respect to the validity or value (or the kind or amount) of any shares of Common Stock, or of any securities or property, which may at any time be issued or delivered upon
the conversion of any Security; and the Trustee and any other Conversion Agent make no representations with respect thereto. Neither the Trustee nor any Conversion Agent shall be responsible for any failure of the Company to issue, transfer or
deliver any cash or shares of Common Stock or stock certificates or other securities or property upon the surrender of any Security for the purpose of conversion or to comply with any of the duties, responsibilities or covenants of the Company
contained in this Article Ten. Without limiting the generality of the foregoing, neither the Trustee nor any Conversion Agent shall be under any responsibility to determine whether a supplemental indenture needs to be entered into pursuant to
Section 8.03 or the correctness of any provisions contained in any supplemental indenture relating either to the kind or amount of shares of stock or securities or property (including cash) receivable by Holders upon the conversion of their
Securities after any Reorganization Event or to any adjustment to be made with respect thereto, but, subject to the provisions of Section 5.01, may accept as conclusive evidence of the correctness of any such provisions, and shall be fully
protected in relying upon, the Officers’ Certificate (which the Company shall be obligated to file with the Trustee prior to the execution of any such supplemental indenture) with respect thereto. 

Section 10.05 Notice to Holders Prior to Certain Actions. 

In case: 
 (1) the Company shall
declare a dividend (or any other distribution) on the Common Stock that would require an adjustment in the Conversion Rate pursuant to Section 10.02; 

(2) the Company shall authorize the granting to the holders of all or substantially all of the Common Stock of rights or warrants to subscribe
for or purchase any shares of Common Stock; or 
 (3) of any reclassification or reorganization of the Common Stock of the Company (other
than a subdivision or combination of its outstanding Common Stock, or a change in par value, or from par value to no par value, or from no par value to par value), or of any consolidation or merger or similar transaction to which the Company or any
Significant Subsidiary is a party and for which approval of any stockholders of the Company is required, or of the sale or transfer of all or substantially all of the assets of the Company or any Significant Subsidiary; or 

(4) of the voluntary or involuntary dissolution, liquidation or winding up of the Company, 

then the Company shall cause to be filed with the Trustee and to be mailed to each Holder of Securities at his address appearing on the
Securities Register provided for in Section 3.05 of this Indenture, as promptly as possible but in any event at least 20 days prior to the applicable date hereinafter specified, a notice stating (x) the date on which a record is to be
taken for the purpose of such dividend, distribution or granting of rights or warrants, or, if a record is not to be taken, the date as of which the holders of Common Stock of record to be entitled to such dividend, distribution or rights are to be
determined, or (y) the date on which such 

  
 53 

 
reclassification, reorganization, consolidation, merger, sale, transfer, dissolution, liquidation or winding up is expected to become effective or occur, and the date as of which it is expected
that holders of Common Stock of record shall be entitled to exchange their Common Stock for securities or other property deliverable upon such reclassification, reorganization, consolidation, merger, sale, transfer, dissolution, liquidation or
winding up. Failure to give such notice, or any defect therein, shall not affect the legality or validity of such dividend, distribution, reclassification, reorganization, consolidation, merger, sale, transfer, dissolution, liquidation or winding
up. 
 Section 10.06 Stockholder Rights Plan. 

To the extent that the Company has a rights plan in effect upon conversion of the Securities into Common Stock, Holders that convert their
Securities will receive, in addition to the Common Stock, the rights under the rights plan, unless prior to any conversion, the rights have separated from the Common Stock, in which case, and only in such case, the Conversion Rate will be adjusted
at the time of separation as if the Company distributed to all holders of Common Stock shares of Capital Stock, evidences of indebtedness or assets as described in Section 10.02(3) above, subject to readjustment in the event of the expiration,
termination or redemption of such rights. In lieu of any such adjustment, the Company may amend such applicable stockholder rights agreement to provide that upon conversion of the Securities the Holders will receive, in addition to the Common Stock
issuable upon such conversion, the rights which would have attached to such Common Stock if the rights had not become separated from the Common Stock under such applicable stockholder rights agreement. 

ARTICLE XI 
 REDEMPTION

 Section 11.01 Redemptions. 

(1) Notwithstanding any provision to the contrary contained herein, each Holder shall be entitled to redeem for cash, in full or in part, in
increments of $50,000, or the full amount of such Security, if less, the principal amount of such Holder’s Security by delivering written notice to the Redemption Agent in accordance with the terms of this Article 11. 

(2) Redemption Procedures. The following procedures shall apply to redemption of Securities: 

(a) In respect of a Definitive Security, a Holder must (A) complete and manually sign the redemption notice on the back of the Security,
or a facsimile of such redemption notice; (B) deliver such redemption notice, which is irrevocable, and the Security to the Redemption Agent; (C) if required, furnish appropriate endorsements and transfer documents as may be required by
the Redemption Agent and, if required pursuant to this Section 11.01, pay all transfer or similar taxes; and (D) if required pursuant to Section 3.11, pay funds equal to the amount of applicable withholding taxes; and 

  
 54 

 (b) In respect of a beneficial interest in a Global Security, a Beneficial Owner must comply with
the Depositary’s procedures for redeeming a beneficial interest in a Global Security and, if required pursuant to Section 3.11, pay funds equal to the amount of applicable withholding taxes, and if required, pay all taxes or duties
required pursuant to Section 11.01(4) below, if any. 
 (3) Cash Payment. Within 5 Business Days of each Redemption Date, the
Redemption Agent shall pay to such redeeming Holder, in cash, the principal amount of the Security being delivered by such Holder for redemption, in full satisfaction of its obligations to such Holder hereunder and under such redeemed Security. In
the case of any redemption in part, the Company shall execute and the Trustee shall, subject to Section 3.06 hereof, execute, authenticate and deliver, in lieu of such delivered Security, a new Security equal in an aggregate principal amount to
the unredeemed portion of the Security so surrendered. 

  
 55 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed, as of the
day and year first above written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ Mauri K. Hodges

		 	Name: Mauri K. Hodges
		 	Title: VP Finance & Administration & Chief     Financial Officer
	
	AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee
		
	By:	 	 /s/ Paul Kim

		 	Name: Paul Kim
		 	Title: Assistant General Counsel

  
 56 

 EXHIBIT A 

FORM OF GLOBAL SECURITY 

TARGACEPT, INC. 
 {FORM OF
FACE OF GLOBAL SECURITY} 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK
CORPORATION, TO TARGACEPT, INC. (THE “COMPANY”) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS TO NOMINEES OF THE DEPOSITORY TRUST COMPANY OR TO A SUCCESSOR THEREOF OR SUCH
SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF. 

  
 Exh - A 

 TARGACEPT, INC. 

Redeemable Convertible Notes due 2018 
  

			
	No.:	  	CUSIP:
		
	Issue Date:	  	Principal Amount:

 TARGACEPT, INC., a Delaware corporation, promises to pay to
                 or its registered assigns, the principal amount as set forth on Schedule I hereto, on February 19, 2018, subject to the further provisions of this
Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. Beneficial interests in this Security are convertible as specified on the other side of this Security. 

Unless the certificate of authentication hereon has been duly executed by the Trustee referred to on the reverse hereof by manual signature,
this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purposes. 
 IN WITNESS WHEREOF,
Targacept, Inc. has caused this Security to be fully executed. 
  

			
	TARGACEPT, INC.
		
	By:	 	  

		 	Name:
		 	Title:

 Dated: 
  

			
	By:	 	  

		 	        Name:
		 	        Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Securities referred to in the within-mentioned Indenture. 

 

			
	AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee
		
	By:	 	  

		 	Authorized Officer

  
 Exh - A 

 {FORM OF REVERSE SIDE OF GLOBAL SECURITY} 

TARGACEPT, INC. 
 Redeemable
Convertible Note due 2018 
 Section 1. Indenture. 

This Security is one of a duly authorized issue of debt securities of Targacept, Inc., a Delaware corporation (such corporation, and its
successors and assigns under the Indenture (as defined below), being herein called the “Company”) designated as its “Redeemable Convertible Notes due 2018” (herein called the “Securities”), issued under an indenture
dated as of August 19, 2015 (as amended or supplemented from time to time, the “Indenture”), by and between the Company and American Stock Transfer & Trust Company, LLC, as trustee (the “Trustee,” which term
includes any successor Trustee under the Indenture). The terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (the “Trust Indenture
Act”), and the Indenture sets forth the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and each Holder of Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. The summary of the terms of this Security contained herein does not purport to be complete and is qualified by reference to the Indenture, and Holders are referred to the Indenture and the Trust Indenture Act for a
statement of the Securities’ terms. Capitalized terms used in this Security that are not defined herein shall have the same meanings assigned to them in the Indenture. 

The Securities are general unsecured obligations of the Company limited to up to $37 million aggregate principal amount. The Indenture does
not limit other indebtedness of the Company, secured or unsecured. 
 Section 2. Principal; No Interest. 

The Company promises to pay on February 19, 2018 (the “Stated Maturity Date”) the principal amount set forth on Schedule
I of this Security to the registered Holder of this Security in the Security Register. This Security will not bear interest. 

Section 3. Method of Payment. 

The Company, through the Paying Agent, shall pay the principal amount (less any amount earlier converted or redeemed) on the Stated Maturity
Date to the Person who is the registered Holder of this Security in the Security Register. The Company shall pay all payments of principal in money of the United States that at the time of payment is legal tender for payment of public and private
debts. 
 Section 4. Escrow Agent, Conversion Agent, Redemption Agent, Security Registrar, and Securities
Custodian.  
 Initially, the Trustee shall act as Paying Agent, Conversion Agent, Redemption Agent, Security Registrar and
Securities Custodian. The Company may appoint and change any Paying Agent, Conversion Agent, Redemption Agent, Security Registrar or Securities Custodian without notice, other than notice to the Trustee. 

  
 Exh - A 

 Section 5. Conversion. 

Subject to the provisions of Article Ten of the Indenture, a Holder of a Security may convert such Security prior to the close of business on
the final Business Day of each calendar month (each such date, as such date may be delayed in accordance with Section 10.02(3) of the Indenture, a “Conversion Date”) into the number of shares of Common Stock equal to the principal
amount of such Security multiplied by the Conversion Rate in effect at such time (in a minimum amount of $50,000 per conversion, or such Holder’s entire principal amount of Securities held, if less), rounded down to the nearest whole share of
Common Stock. No fractional shares shall be issued upon conversion. 
 To convert a beneficial interest in this Security, a Beneficial Owner
must complete and deliver to the Depositary appropriate instructions pursuant to the Depositary’s procedures for converting a beneficial interest in a Global Security and, if required pursuant to Section 3.11 of the Indenture, pay funds
equal to the amount of applicable withholding taxes, and if required, pay all taxes or duties required pursuant to Section 10.01(4) of the Indenture, if any. 

Section 6. Redemption. 

Subject to the provisions of Article Eleven of the Indenture, a Holder of a Security may redeem all or part of a Security prior to the close of
business on a Business Day (at least 5 Business Days prior to the Stated Redemption Date) (each such date, a “Redemption Date”) for cash payment equal to the principal amount of such Security being delivered for redemption at such
time. 
 To redeem a beneficial interest in this Security, a Beneficial Owner must complete and deliver to the Depositary appropriate
instructions pursuant to the Depositary’s procedures for converting a beneficial interest in a Global Security and, if required pursuant to Section 3.11 of the Indenture, pay funds equal to the amount of applicable withholding taxes, and
if required, pay all taxes or duties required pursuant to Section 11.01 of the Indenture, if any. In the case of any redemption in part, the Company shall execute and the Trustee shall, subject to Section 3.06 of the Indenture, execute,
authenticate and deliver, in lieu of such delivered Security, a new Security equal in an aggregate principal amount to the unredeemed portion of the Security so surrendered. 

Section 7. Global Security. 

So long as this Security is registered in the name of the Depositary, members of, or participants in, the Depositary (“Agent
Members”) shall have no rights under the Indenture with respect to this Security held on their behalf by the Depositary, or the Trustee as its custodian, or under this Security, and the Depositary may be treated by the Company, the Trustee
or any agent of the Company or Trustee as the absolute owner of this Security for all purposes whatsoever. Notwithstanding the foregoing, nothing contained in the Indenture or this Security shall prevent the Company, the Trustee or any agent of the
Company or Trustee from giving effect to any 

  
 Exh - A 

 
written certification, proxy or other authorization furnished by the Depositary or impair, as between the Depositary and the Agent Members, the operation of customary practices governing the
exercise of the rights of a Holder of any Security. 
 The Holder of this Security may grant proxies and otherwise authorize any Person,
including Agent Members and Persons that may hold interests through Agent Members, to take any action which a Holder is entitled to take under the Indenture or the Securities. 

Whenever, as a result of conversion of beneficial interests in this Security or the exchange of a portion of this Security for Definitive
Securities, this Security is converted or exchanged in part, this Security shall be surrendered by the Holder hereof to the Trustee who shall cause an adjustment to be made on Schedule I hereof so that the principal amount of this Security shall be
equal to the portion not converted or exchanged and shall thereafter return this Security to such Holder. 
 Section 8.
Transfer and Exchange. 
 The Holder of this Security shall, by acceptance of this Security, agree that the transfers of
beneficial interests in this Security may be effected only though a book-entry system maintained by such Holder (or its agent), and that ownership of a beneficial interest shall be required to be reflected in book-entry form. 

Transfers of this Security shall be limited to transfers, in whole or in part, to the Depositary (or a nominee thereof). Interests in
beneficial owners in this Global Security may be transferred in accordance with the rules and procedures of the Depositary. 
 This Security
shall be exchanged by the Company for one or more Definitive Securities if (i) the Depositary notifies the Company in writing that it is unwilling or unable to continue to act as Depositary for this Security and a successor Depositary for this
Security is not appointed by the Company within 90 days of such notice, (ii) the Depositary ceases to be registered as a “clearing agency” under the Exchange Act and a successor depositary for this Security is not appointed by the
Company within 90 days of such cessation, (iii) the Company, at its option, notifies the Trustee in writing that it elects to cause the issuance of the Definitive Securities under this Indenture in exchange for all or any part of the Securities
represented by this Security, subject to the procedures of the Depositary, or (iv) an Event of Default has occurred and is continuing and the Security Registrar has received a request from the Depositary for the issuance of Definitive
Securities in exchange for this Security. Whenever this Security is exchanged for one or more Definitive Securities, the Company shall execute, and the Trustee, upon receipt of an Officers’ Certificate and Company Order for the authentication
and delivery of Securities, shall authenticate and deliver in exchange for this Security, Definitive Securities in an aggregate principal amount equal to the aggregate principal amount of this Security or the portion of this Security exchanged for
Definitive Securities. Such Definitive Securities shall be registered in such names as the Depositary shall identify in writing as the beneficial owners of the Securities represented by this Security. Interests in this Global Security may not be
exchanged for Definitive Securities other than as provided in this paragraph. Whenever this Security is exchanged in whole for one or more Definitive Securities, it shall be surrendered to the Trustee for cancellation. 

  
 Exh - A 

 Section 9. Denominations. 

The Securities are in fully registered form, without coupons, in denominations of $1.00 of principal amount and any multiple thereof. 

Section 10. Unclaimed Money or Securities. 

Any money deposited with the Trustee or any Paying Agent for the payment of principal not converted in accordance with Article Ten of the
Indenture and remains unclaimed for six months after the Stated Maturity Date shall be paid to the Company upon Company Request, subject to any applicable unclaimed property law. After any such payments, Holders entitled to such money must look only
to the Company for payment unless an applicable abandoned property law designates another person. 
 Section 11.
Amendment; Waiver. 
 Subject to certain exceptions set forth in the Indenture, (i) the Indenture or the Securities may be
amended with the written consent of the Holders of at least a majority in aggregate principal amount of the Securities at the time outstanding and (ii) certain Defaults may be waived with the written consent of the Holders of a majority in
aggregate principal amount of the Securities at the time outstanding. Subject to certain exceptions set forth in the Indenture, without the consent of any Holder, the Company and the Trustee may amend the Indenture or the Securities (i) to
evidence the succession of another Person to the Company and the assumption by any such successor of the covenants of the Company under the Indenture and contained in the Securities, (ii) to add additional covenants or to surrender rights and
powers conferred on the Company, (iii) to add any additional evidences of default, (iv) to evidence and provide for the acceptance of appointment under the Indenture of a successor Trustee or (v) to cure any ambiguity in the
Indenture, to correct or supplement any provision of the Indenture which may be inconsistent with any other provision therein, or to make other provisions with respect to matters or questions arising under the Indenture, provided that such actions
shall not adversely affect the interests of the Holders in any material respect. 
 Section 12. Defaults and
Remedies. 
 Except as set forth in the Indenture, if an Event of Default occurs and is continuing, the Trustee or the Holders of not
less than 51% in principal amount of Securities then outstanding may declare all the Securities to be due and payable in the manner, at the time and with the effect provided in the Indenture. Certain events of bankruptcy or insolvency are Events of
Default and shall result in the Securities being immediately due and payable upon the occurrence of such Events of Default without any further act of the Trustee or any Holder. 

Holders of Securities may not enforce the Indenture or the Securities except as provided in the Indenture. The Trustee is not obligated to
enforce the Indenture or the Securities unless it has received indemnity or security reasonably satisfactory to it. The Indenture permits, subject to certain limitations therein provided, Holders of a majority in aggregate principal amount of the
Securities then outstanding to direct the Trustee in its exercise of any trust or power. Subject to certain provisions set forth in the Indenture, Holders of a majority in an aggregate principal 

  
 Exh - A 

 
amount of the Securities at the time outstanding, by written notice to the Company and the Trustee, may rescind any declaration of acceleration due to an Event of Default, and the applicable
Event of Default shall be deemed to have been cured for every purpose of the Indenture. 
 Section 13. Individual Rights
of Trustee and Other Agents. 
 Subject to certain limitations imposed by the Trust Indenture Act, the Trustee or any Paying Agent,
Conversion Agent, Redemption Agent, Security Registrar, Securities Custodian or Authenticating Agent, in its individual or other capacity, may become the owner or pledgee of Securities and may otherwise deal with the Company or its Affiliates with
the same rights it would have if it were not Trustee, Escrow Agent, Conversion Agent, Redemption Agent, Security Registrar, Securities Custodian or Authenticating Agent. 

Section 14. No Recourse Against Others. 

A director, officer, employee or shareholder, as such, of the Company shall not have any liability for any obligations of the Company under the
Securities or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. By accepting a Security, each Holder waives and releases all such liability. The waiver and release are part of the
consideration for the issue of the Securities. 
 Section 15. Authentication. 

This Security shall not be valid until an authorized signatory of the Trustee manually signs the Trustee’s Certificate of Authentication
on the other side of this Security. 
 Section 16. Governing Law. 

THE LAWS OF THE STATE OF NEW YORK SHALL GOVERN THE INDENTURE AND THIS SECURITY. 

  
 Exh - A 

					
	ASSIGNMENT FORM	  		 	CONVERSION NOTICE
			
	To assign this Security, fill in the form below	  		 	 To convert this Security into Common Stock of the

Company, check the box   ̈

			
	I or we assign and transfer this Security to	  		 	 To convert only part of this Security, state the principal

amount to be converted:

		  		 
			
	(Insert assignee’s soc. sec. or tax ID no.)	  		 	If you want the stock certificate made out in another person’s name fill in the form below:
		  		 
			
		  		 	 
			
	 (Print or type assignee’s name, address and zip code)
	  		 	
	and irrevocably appoint                      as agent to transfer this Security on the books of the Company. The agent may
substitute another to act for him.	  		 	
			
		  		 	(Insert the other person’s soc. sec. tax ID no.)
			
		  		 	(Print or type other person’s name, address and zip code)
			
	Date:                            	  		 	Your
Signature:                                       
                             
			
		  		 	 (Sign exactly as your name appears on the other side of

this Security)

			
	Signature Guaranteed	  		 	
	 	  		 	
	 Participant in a Recognized Signature Guarantee

Medallion Program
	  		 	
			
	By:                                     
                       	  		 	
	        Authorized Signatory	  		 	

  
 Exh - A 

					
	REDEMPTION NOTICE	  		 	
			
	 To redeem this Security into Common Stock of the

Company, check the box   ̈
	  		 	
			
	 To redeem only part of this Security, state the principal

amount to be redeemed:
	  		 	
			
	 	  		 	
			
	(Insert the other person’s soc. sec. tax ID no.)	  		 	
			
	(Print or type other person’s name, address and zip code)	  		 	
			
	Your
Signature:                                       
         	  		 	
			
	 (Sign exactly as your name appears on the other side of

this Security)
	  		 	

  
 Exh - A 

 SCHEDULE I 

TARGACEPT, INC. 
 Redeemable
Convertible Notes due 2018 
  

					
	 Date
	  	 Principal Amount
	  	 Notation

		  		  	
		  		  	
		  		  	
		  		  	

  
 Exh - A 

 EXHIBIT B 

FORM OF DEFINITIVE SECURITY 

TARGACEPT, INC. 

Redeemable Convertible Notes due 2018 
  

			
	No.:	  	CUSIP:
		
	Issue Date:	  	Principal Amount:

 TARGACEPT, INC., a Delaware corporation, promises to pay to
                 or its, his or her registered assigns, the principal amount of $            , on
February 19, 2018, subject to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. This Security is convertible as specified
on the other side of this Security. 
 Unless the certificate of authentication hereon has been duly executed by the Trustee referred to on
the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purposes. 

IN WITNESS WHEREOF, Targacept, Inc. has caused this Security to be fully executed. 

Dated: 
  

			
	TARGACEPT, INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Securities referred to in the within-mentioned Indenture. 

 

			
	AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee
		
	By:	 	  

		 	Authorized Officer

  
 Exh - B 

 {FORM OF REVERSE SIDE OF DEFINITIVE SECURITY} 

TARGACEPT, INC. 
 Redeemable
Convertible Note due 2018 
 Section 1. Indenture. 

This Security is one of a duly authorized issue of debt securities of Targacept, Inc., a Delaware corporation (such corporation, and its
successors and assigns under the Indenture (as defined below), being herein called the “Company”) designated as its “Redeemable Convertible Notes due 2018” (herein called the “Securities”), issued under an
indenture dated as of , 2015 (as amended or supplemented from time to time, the “Indenture”), by and between the Company and American Stock Transfer & Trust Company, LLC, as trustee (the “Trustee,” which term
includes any successor Trustee under the Indenture). The terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (the “Trust Indenture
Act”), and the Indenture sets forth the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and each Holder of Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. The summary of the terms of this Security contained herein does not purport to be complete and is qualified by reference to the Indenture, and Holders are referred to the Indenture and the Trust Indenture Act for a
statement of the Securities’ terms. Capitalized terms used in this Security that are not defined herein shall have the same meanings assigned to them in the Indenture. 

The Securities are general unsecured obligations of the Company limited to up to $37 million aggregate principal amount. The Indenture does
not limit other indebtedness of the Company, secured or unsecured. 
 Section 2. Principal; No Interest. 

The Company promises to pay on February 19, 2018 (the “Stated Maturity Date”) the principal amount of $ to the registered
Holder of this Security in the Security Register. This Security will not bear interest. 
 Section 3. Method of
Payment. 
 The Company, through the Paying Agent, shall pay the principal amount on the Stated Maturity Date to the Person who is
the registered Holder of this Security in the Security Register. The Company shall pay all payments of principal in money of the United States that at the time of payment is legal tender for payment of public and private debts. 

Section 4. Escrow Agent, Conversion Agent, Redemption Agent, Security Registrar, and Securities Custodian. 

Initially, the Trustee shall act as Paying Agent, Conversion Agent, Redemption Agent, Security Registrar and Securities Custodian. The Company
may appoint and change any Paying Agent, Conversion Agent, Redemption Agent, Security Registrar or Securities Custodian without notice, other than notice to the Trustee. 

  
 Exh - B 

 Section 5. Conversion. 

Subject to the provisions of Article Ten of the Indenture, a Holder of a Security may convert such Security prior to the close of business on
the final Business Day of each calendar month (each such date, as such date may be delayed in accordance with Section 10.02(3) of the Indenture, a “Conversion Date”) into the number of shares of Common Stock equal to the principal
amount of such Security multiplied by the Conversion Rate in effect at such time (in a minimum amount of $50,000 per conversion, or such Holder’s entire principal amount of Securities held, if less), rounded down to the nearest whole share of
Common Stock. No fractional shares shall be issued upon conversion. 
 To convert this Security, its Holder must (i) complete and
manually sign the conversion notice on the back of the Security, or a facsimile of such conversion notice, (ii) deliver such conversion notice, which is irrevocable, and the Security to the Conversion Agent on or prior to the applicable
Conversion Date, (iii) if required, furnish appropriate endorsements and transfer documents as may be required by the Conversion Agent and, if required pursuant to Section 10.01(4) of the Indenture, pay all transfer or similar taxes and
(iv) if required pursuant to Section 3.11 of the Indenture, pay funds equal to the amount of applicable withholding taxes. 

Section 6. Redemption. 

Subject to the provisions of Article Eleven of the Indenture, a Holder of a Security may redeem such Security prior to the close of business on
a Business Day (each such date, a “Redemption Date”) for cash payment equal to the entire outstanding principal amount of such Outstanding Security at such time. 

To redeem this Security, its Holder must (i) complete and manually sign the redemption notice on the back of the Security, or a facsimile
of such redemption notice, (ii) deliver such redemption notice, which is irrevocable, and the Security to the Redemption Agent on the Redemption Date and (iii) if required pursuant to Section 3.11 of the Indenture, pay funds equal to
the amount of applicable withholding taxes. 
 Section 7. Persons Deemed Owners. 

The registered Holder of this Security in the Security Register may be treated as the owner of this Security for all purposes. 

Section 8. Transfer and Exchange. 

A Holder may transfer and exchange Securities in accordance with the Indenture. The Security Registrar may require a Holder, among other
things, to furnish appropriate endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. 

  
 Exh - B 

 Section 9. Denominations. 

The Securities are in fully registered form, without coupons, in denominations of $1.00 of principal amount and any multiple thereof. 

Section 10. Unclaimed Money or Securities. 

Any money deposited with the Trustee or any Paying Agent for the payment of principal not converted in accordance with Article Ten of the
Indenture and remains unclaimed for six months after the Stated Maturity Date shall be paid to the Company upon Company Request, subject to any applicable unclaimed property law. After any such payments, Holders entitled to such money must look only
to the Company for payment unless an applicable abandoned property law designates another person. 
 Section 11.
Amendment; Waiver. 
 Subject to certain exceptions set forth in the Indenture, (i) the Indenture or the Securities may be
amended with the written consent of the Holders of at least a majority in aggregate principal amount of the Securities at the time outstanding and (ii) certain Defaults may be waived with the written consent of the Holders of a majority in
aggregate principal amount of the Securities at the time outstanding. Subject to certain exceptions set forth in the Indenture, without the consent of any Holder, the Company and the Trustee may amend the Indenture or the Securities (i) to
evidence the succession of another Person to the Company and the assumption by any such successor of the covenants of the Company under the Indenture and contained in the Securities, (ii) to add additional covenants or to surrender rights and
powers conferred on the Company, (iii) to add any additional evidences of default, (iv) to evidence and provide for the acceptance of appointment under the Indenture of a successor Trustee or (v) to cure any ambiguity in the
Indenture, to correct or supplement any provision of the Indenture which may be inconsistent with any other provision therein, or to make other provisions with respect to matters or questions arising under the Indenture, provided that such actions
shall not adversely affect the interests of the Holders in any material respect. 
 Section 12. Defaults and
Remedies. 
 Except as set forth in the Indenture, if an Event of Default occurs and is continuing, the Trustee or the Holders of not
less than 51% in principal amount of Securities then outstanding may declare all the Securities to be due and payable in the manner, at the time and with the effect provided in the Indenture. Certain events of bankruptcy or insolvency are Events of
Default and shall result in the Securities being immediately due and payable upon the occurrence of such Events of Default without any further act of the Trustee or any Holder. 

Holders of Securities may not enforce the Indenture or the Securities except as provided in the Indenture. The Trustee is not obligated to
enforce the Indenture or the Securities unless it has received indemnity or security reasonably satisfactory to it. The Indenture permits, subject to certain limitations therein provided, Holders of a majority in aggregate principal amount of the
Securities then outstanding to direct the Trustee in its exercise of any trust or power. Subject to certain provisions set forth in the Indenture, Holders of a majority in an aggregate principal amount of the Securities at the time outstanding, by
written notice to the Company and the Trustee, may rescind any declaration of acceleration due to an Event of Default, and the applicable Event of Default shall be deemed to have been cured for every purpose of the Indenture. 

  
 Exh - B 

 Section 13. Individual Rights of Trustee and Other Agents. 

Subject to certain limitations imposed by the Trust Indenture Act, the Trustee or any Paying Agent, Conversion Agent, Security Registrar,
Securities Custodian or Authenticating Agent, in its individual or other capacity, may become the owner or pledgee of Securities and may otherwise deal with the Company or its Affiliates with the same rights it would have if it were not Trustee,
Paying Agent, Conversion Agent, Security Registrar, Securities Custodian or Authenticating Agent. 
 Section 14. No
Recourse Against Others. 
 A director, officer, employee or shareholder, as such, of the Company shall not have any liability for
any obligations of the Company under the Securities or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. By accepting a Security, each Holder waives and releases all such liability. The
waiver and release are part of the consideration for the issue of the Securities. 
 Section 15. Authentication.

 This Security shall not be valid until an authorized signatory of the Trustee manually signs the Trustee’s Certificate of
Authentication on the other side of this Security. 
 Section 16. Governing Law. 

THE LAWS OF THE STATE OF NEW YORK SHALL GOVERN THE INDENTURE AND THIS SECURITY. 

  
 Exh - B 

					
	ASSIGNMENT FORM	  		 	CONVERSION NOTICE
			
	To assign this Security, fill in the form below	  		 	 To convert this Security into Common Stock of the

Company, check the box   ̈

			
	I or we assign and transfer this Security to	  		 	 To convert only part of this Security, state the principal

amount to be converted:

	 	  		 
	 	  		 	
		  		 	
			
	(Insert assignee’s soc. sec. or tax ID no.)	  		 	If you want the stock certificate made out in another person’s name fill in the form below:
		  		 
	 	  		 	 
	 	  		 	 
			
	 (Print or type assignee’s name, address and zip code)
	  		 	
	 	  		 	
	 	  		 	
	 	  		 	
	and irrevocably appoint                      as agent to transfer this	  		 	(Insert the other person’s soc. sec. tax ID no.)
	Security on the books of the Company. The agent may	  		 	 
	substitute another to act for him.	  		 	 
			
		  		 	(Print or type other person’s name, address and zip code)
			
	Date:                            	  		 	Your
Signature:                                       
                             
			
		  		 	 (Sign exactly as your name appears on the other side of

this Security)

			
	Signature Guaranteed	  		 	
	 	  		 	
	 Participant in a Recognized Signature Guarantee

Medallion Program
	  		 	
			
	By:                                     
                       	  		 	
	        Authorized Signatory	  		 	

  
 Exh - B 

					
	REDEMPTION NOTICE	  		 	
			
	 To redeem this Security into Common Stock of the

Company, check the box   ̈
	  		 	
			
	 To redeem only part of this Security, state the principal

amount to be redeemed:
	  		 	
			
	(Insert the other person’s soc. sec. tax ID no.)	  		 	
	 	  		 	
			
	 	  		 	
			
	(Print or type other person’s name, address and zip code)	  		 	
			
	Your
Signature:                                       
         	  		 	
			
	 (Sign exactly as your name appears on the other side of

this Security)
	  		 	

  
 Exh - B 

 EXHIBIT C 

ESCROW AGREEMENT 

  
 Exh - CEX-10.1

 Exhibit 10.1 

ESCROW AGREEMENT 
 This
Escrow Agreement (this “Agreement”) is made as of August 19, 2015, by and among Targacept, Inc., a Delaware corporation (the “Company”), American Stock Transfer & Trust Company, LLC, a New York limited liability
trust company, as trustee under the Indenture (as defined below) (the “Trustee”), and Delaware Trust Company, as escrow agent hereunder (the “Escrow Agent” and together with the Trustee, the “Agents”). Capitalized terms
used herein that are not otherwise defined herein shall have the meanings set forth in the Indenture. 
 BACKGROUND 

A. The Company has entered into an Agreement and Plan of Merger, dated as of March 5, 2015 (the “Merger Agreement”), by and
among the Company, Catalyst Biosciences, Inc., a Delaware corporation (“Catalyst”), and Talos Merger Sub, Inc., a Delaware corporation and wholly-owned subsidiary of the Company. 

B. Pursuant to the Merger Agreement, the Company and American Stock Transfer & Trust Company, LLC, a New York limited liability trust
company, as trustee (the “Trustee”), have entered into that certain Indenture dated as of the date hereof (as amended, restated or otherwise modified from time to time, the “Indenture”), pursuant to which the Company has issued
to certain holders of the Company’s Common Stock, Redeemable Convertible Notes due 2017 (the “Securities”) for an aggregate principal amount of $37,000,000. To provide for the payment of the Securities by redemption or at maturity in
accordance with the terms of the Indenture, the Company desires to deliver to the Escrow Agent an amount equal to the principal amount of the Securities, to be deposited and held in an escrow account for the benefit of the Company and the holders of
the Securities (the “Security Holders” and, together with the Company, hereinafter sometimes referred to collectively as the “Beneficiaries”). 

C. The Merger Agreement provides that the Company shall deposit the Escrow Funds (defined below) in a segregated escrow account to be held by
the Escrow Agent and to be disbursed by the Escrow Agent in accordance with the terms herein so as to effectuate payment of the Securities under the Indenture. 

D. The Escrow Agent has agreed to accept, hold, and disburse the funds deposited with it and the earnings thereon in accordance with the terms
of this Agreement. 
 E. In order to establish the escrow of funds and to effect certain provisions of the Merger Agreement and the
Indenture, the parties hereto have entered into this Agreement. 

 STATEMENT OF AGREEMENT 

NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby
agree as follows: 
 1. Definitions. The following terms shall have the following meanings when used herein: 

“Escrow Funds” shall mean the funds deposited with the Escrow Agent pursuant to Section 3 of this Agreement,
together with any interest and other income thereon. 
 “Representatives” shall mean, collectively, the individuals
identified in the notice provisions hereof for the Company and the Trustee. 
 2. Appointment of and Acceptance by Escrow Agent. The
Company and the Trustee hereby appoint the Escrow Agent to serve as escrow agent hereunder. The Escrow Agent hereby accepts such appointment and, upon receipt by wire transfer of the Escrow Funds in accordance with Section 3 below,
agrees to hold, invest and disburse the Escrow Funds in accordance with this Agreement. 
 3. Deposit of Escrow Funds; Creation of
Escrow. Simultaneously with the execution and delivery of this Agreement, the Company will transfer the Escrow Funds in the amount set forth on Schedule A hereto to the Escrow Agent, by wire transfer of immediately available funds, to the
account of the Escrow Agent referenced on Schedule A hereto. The Company, the Trustee and the Escrow Agent each agree that: 
  

	 	(i)	this Agreement is intended to establish an escrow arrangement with respect to the Escrow Funds; 

  

	 	(ii)	the deposit of the Escrow Funds with the Escrow Agent shall be and is an irrevocable and actual transfer by the Company of the Escrow Funds to the Escrow Agent; 

 

	 	(iii)	after the deposit of the Escrow Funds with the Escrow Agent, the Company shall be divested of, and shall have no rights in the Escrow Funds unless, until (and then only to the extent) any Escrow Funds become payable to
the Company under the terms of this Agreement. For the avoidance of doubt, the Company shall have no rights to possess or control any Escrow Funds held by the Escrow Agent unless, until (and then only to the extent) any Escrow Funds become payable
to the Company under the terms of this Agreement; and 

  

	 	(iv)	 It is the specific intent of the parties that in the event the Company becomes a debtor under Title 11 of the United States Code or any other state or
federal proceeding 

  
 -2- 

	 	
relating to the reorganization, liquidation or winding up of the Company, the Company’s sole rights in and interest with respect to the Escrow Funds shall be its contractual rights under
this Agreement. 

 4. Disbursements of Escrow Funds. The Escrow Agent shall hold and will not disburse any of the
Escrow Funds except as described below: 
  

	 	(a)	Transfer to Trustee Upon a Holder Redemption. The Escrow Agent shall release that portion of the Escrow Funds to the Trustee, for payment by the Trustee in satisfaction of such Redemption pursuant to
Section 11.01 of the Indenture, on the first Business Day following presentment of a written notice from the Trustee informing the Escrow Agent that a Security Holder has redeemed a Security under Section 11.01 of the Indenture (a
“Redemption Notice”) along with a copy of the certificate set forth in Exhibit A attached hereto; 

  

	 	(b)	Transfer to Company Upon a Holder Conversion. Provided that the Trustee has given the Escrow Agent two (2) Business Days’ notice prior to the Conversion Date along with a copy of the certificate (the
“Conversion Certificate”) set forth in Exhibit B attached hereto (or if no such prior notice has been provided, as soon as reasonably possible after such Conversion Date upon receipt of such notice and certificate from the Trustee),
the Escrow Agent shall release to the Company, to an account designated in writing by the Company, on any date the Company issues shares of the Company’s Common Stock to the Security Holders who have elected to convert Securities into Company
Common Stock in satisfaction of and pursuant to a Conversion Notice and in accordance with Section 10.01(2) of the Indenture, as of the most recent Conversion Date, an amount to equal the aggregate amount of the principal of the Securities
converted by such Security Holders into shares of the Company’s Common Stock on such Conversion Date as set forth in the Conversion Certificate; 

  

	 	(c)	Transfer to Trustee on the Stated Maturity Date. The Escrow Agent shall release that portion of the Escrow Funds to the Trustee, for payment by the Trustee to the Security Holders in satisfaction of the full
settlement amount, in cash, of the outstanding principal amount of the Securities in accordance with the Indenture, one (1) Business Day prior to the Stated Maturity Date in accordance with a written notice delivered by Trustee to Escrow Agent
which shall include the amount to be released and payment instructions for the Trustee; 

  

	 	(d)	Transfer to Company. No later than fifteen (15) Business Days after the Stated Maturity Date (or termination of the Indenture (other than any contingent indemnification obligations), if earlier in which case
the Company and Trustee shall deliver joint written instructions to Escrow Agent with regard to such termination or contingent indemnification obligation), any remaining Escrow Funds shall be released to the Company in full to an account designated
in writing by the Company. 

  
 -3- 

 All disbursements of funds from the Escrow Funds shall be subject to the fees and claims of the Escrow Agent and
the Indemnified Parties (as defined below) pursuant to Section 10 and Section 12 below. 
 5. Suspension of
Performance; Disbursement Into Court. If, at any time, (i) there shall exist any dispute between or among the Company, the Trustee or the Escrow Agent with respect to the holding or disposition of any portion of the Escrow Funds or any
other obligations of the Escrow Agent under this Agreement, (ii) the Escrow Agent is unable to determine, to the Escrow Agent’s sole satisfaction, the proper disposition of all or any portion of the Escrow Funds or the Escrow Agent’s
proper actions with respect to its obligations under this Agreement, or (iii) the Representatives have not within 30 days of the furnishing by the Escrow Agent of a notice of resignation pursuant to Section 7 hereof, appointed a
successor Escrow Agent to act hereunder, then the Escrow Agent shall take either or both of the following actions: 
 a.
suspend the performance of any of its obligations (including without limitation any disbursement obligations) under this Agreement until such dispute or uncertainty shall be resolved to the sole satisfaction of the Escrow Agent by receiving a joint
written instruction of Company and Trustee or such other resolution acceptable to Escrow Agent or until a successor Escrow Agent shall have been appointed (as the case may be). 

b. petition (by means of an interpleader action or any other appropriate method) any court of competent jurisdiction in any
venue convenient to the Escrow Agent, for instructions with respect to such dispute or uncertainty, and to the extent required or permitted by law, pay into such court, for holding and disposition in accordance with the instructions of such court,
all Escrow Funds, after deduction and payment to the Escrow Agent of all fees and expenses (including court costs and attorneys’ fees) payable to, incurred by, or expected to be incurred by the Escrow Agent in connection with the performance of
its duties and the exercise of its rights under this Agreement. 
 The Escrow Agent shall have no liability to the Company, the Trustee or any Security
Holder, their respective shareholders or members or any other person with respect to any such suspension of performance or disbursement into court, specifically including any liability or claimed liability that may arise, or be alleged to have
arisen, out of or as a result of any delay in the disbursement of the Escrow Funds or any delay in or with respect to any other action required or requested of the Escrow Agent. 

6. Investment of Funds. The Escrow Agent is herein directed and instructed to invest and reinvest the Escrow Funds in the investments
indicated on Schedule A hereto. Each of the foregoing investments shall be made in the name of the Escrow Agent. No investment shall be made in 

  
 -4- 

 
any instrument or security that has a maturity of greater than six (6) months. Notwithstanding anything to the contrary contained herein, the Escrow Agent may, without notice to the
Representatives, sell or liquidate any of the foregoing investments at any time if the proceeds thereof are required for any disbursement of the Escrow Funds permitted or required under this Agreement. All investment earnings shall become part of
the Escrow Funds and investment losses shall be charged against the Escrow Funds. The Escrow Agent shall not be liable or responsible for loss in the value of any investment made pursuant to this Agreement, or for any loss, cost or penalty resulting
from any sale or liquidation of the Escrow Funds. With respect to any Escrow Funds received by the Escrow Agent after ten o’clock, a.m., Eastern time, the Escrow Agent shall not be required to invest such funds or to effect any investment
instruction until the next day upon which banks or trust companies in New York City, New York or Wilmington, Delaware are open for business. All interest or other income earned under the Escrow Agreement shall be allocated to the Company and
reported, to the extent required by law, by the Escrow Agent to the IRS or any other taxing authority, as applicable, on IRS form 1099-INT, 1099-DIV or 1042S (or other appropriate form) as income earned from the Escrow Fund by the Company whether or
not said income has been distributed during the year. Unless otherwise agreed to in writing by Escrow Agent, all income tax returns required to be filed with the IRS and any other taxing authority as required by law with respect to such income shall
be timely filed by Company. The parties hereto acknowledge and agree that the Escrow Agent shall have no responsibility for the preparation and/or filing of any income tax return with respect to income earned from the Escrow Fund by the
Company. Notwithstanding anything to the contrary set forth herein, the Escrow Agent will annually (during the month of January) distribute to the Company an amount equal to all earnings on the Escrow Funds. The Escrow Agent shall withhold any
taxes as required by law, including but not limited to required withholding in the absence of proper tax documentation, and shall remit such taxes to the appropriate authorities as required by any law or regulation in effect at the time of the
distribution and shall comply with its reporting obligations as required by law. 
 7. Resignation of Escrow Agent. The Escrow Agent
may resign and be discharged from the performance of its duties hereunder at any time by giving thirty (30) days’ prior written notice to the Company and the Trustee specifying a date when such resignation shall take effect. Upon any such
notice of resignation, the Representatives jointly shall appoint a successor Escrow Agent hereunder prior to the effective date of such resignation. The retiring Escrow Agent shall transmit all records pertaining to the Escrow Funds and shall pay
all Escrow Funds to the successor Escrow Agent, after making copies of such records as the retiring Escrow Agent deems advisable and after deduction and payment to the retiring Escrow Agent of all reasonable fees and expenses (including court costs
and attorneys’ fees) payable to, incurred by, or expected to be incurred by the retiring Escrow Agent in connection with the performance of its duties and the exercise of its rights hereunder. After any retiring Escrow Agent’s resignation,
the provisions of this Agreement shall inure to its benefit as to any actions taken or omitted by it while it was Escrow Agent under this Agreement. The Escrow Agent’s resignation shall be effective upon the acceptance by the successor Escrow
Agent as escrow agent under this Agreement 

  
 -5- 

 8. Liability of Escrow Agent. The Escrow Agent undertakes to perform only such duties as
are expressly set forth herein and no duties shall be implied. The Escrow Agent shall have no liability under and no duty to inquire as to the provisions of any agreement other than this Agreement. The Escrow Agent shall not be liable for any action
taken or omitted by it in good faith except to the extent that a court of competent jurisdiction determines that the Escrow Agent’s gross negligence or willful misconduct was the primary cause of any loss to the Purchaser or Seller. The Escrow
Agent’s sole responsibility shall be for the safekeeping and disbursement of the Escrow Funds in accordance with the terms of this Agreement. The Escrow Agent shall have no implied duties or obligations and shall not be charged with knowledge
or notice of any fact or circumstance not specifically set forth herein. The Escrow Agent may rely upon any notice, instruction, request or other instrument, not only as to its due execution, validity and effectiveness, but also as to the truth and
accuracy of any information contained therein, which the Escrow Agent shall believe to be genuine and to have been signed or presented by the person or parties purporting to sign the same. In no event shall the Escrow Agent be liable for incidental,
indirect, special, consequential or punitive damages (including, but not limited to lost profits), even if the Escrow Agent has been advised of the likelihood of such loss or damage and regardless of the form of action. The Escrow Agent shall not be
obligated to take any legal action or commence any proceeding in connection with the Escrow Funds, any account in which Escrow Funds are deposited, or this Agreement, or to appear in, prosecute or defend any such legal action or proceeding. The
Escrow Agent may consult legal counsel selected by it in the event of any dispute or question as to the construction of any of the provisions hereof or of any other agreement or of its duties hereunder, or relating to any dispute involving any party
hereto, and shall incur no liability and shall be fully indemnified from any liability whatsoever in acting in accordance with the opinion or instruction of such counsel. The Company shall promptly pay, upon demand, the reasonable fees and expenses
of any such counsel. 
 The Escrow Agent is authorized, in its sole discretion, to comply with orders issued or process entered by any court
with respect to the Escrow Funds, without determination by the Escrow Agent of such court’s jurisdiction in the matter. If any portion of the Escrow Funds is at any time attached, garnished or levied upon under any court order, or in case the
payment, assignment, transfer, conveyance or delivery of any such property shall be stayed or enjoined by any court order, or in case any order, judgment or decree shall be made or entered by any court affecting such property or any part thereof,
then and in any such event, the Escrow Agent is authorized, in its sole discretion, to rely upon and comply with any such order, writ, judgment or decree which it is advised by legal counsel selected by it is binding upon it without the need for
appeal or other action; and if the Escrow Agent complies with any such order, writ, judgment or decree, it shall not be liable to any of the parties hereto or to any other person or entity by reason of such compliance even though such order, writ,
judgment or decree may be subsequently reversed, modified, annulled, set aside or vacated. 
 Notwithstanding anything to the contrary
herein before contained, the Escrow Agent shall have the right to consult with Counsel (including Counsel to the Company) for advice and assistance in exercising its duties under this Agreement and the advice and/ or assistance given by Counsel
shall 

  
 -6- 

 
be complete authorization and protection in respect of any action taken, suffered or omitted by the Escrow Agent hereunder in reliance thereon. The Company shall be liable for and shall pay on
demand, any reasonable fees and expenses of the Counsel consulted by the Escrow Agent. 
 9. Indemnification. The Company covenants
and agrees to hold each of the Agents harmless and indemnify each of the Agents from and against, any and all reasonable, documented and out-of-pocket expenses, including reasonable counsel fees and disbursements, or loss suffered by the Agents in
connection with any action, suit or other proceeding brought against the Agents involving any claim, or in connection with any claim or demand which in any way arises out of or relates to this Agreement, the services of the Agents hereunder or the
Property or any income earned from investment of the Property, except for expenses and losses resulting from either or both of the Agents’ gross negligence, bad faith or willful misconduct. Promptly after the receipt by either or both of the
Agents of notice of demand or claim or the commencement of any action, suit or proceeding, pursuant to which the Agents, as applicable, intend to seek indemnification under this paragraph, either or both of the Agents shall notify the Company in
writing of such claim (hereinafter referred to as the “Indemnified Claim”). Each of the Agents, as applicable, shall have the right to conduct and manage the defense against such Indemnified Claim; provided that each of the Agents, as
applicable, shall obtain the consent of the Company should they choose to engage a single counsel for both the Escrow Agent and Trustee, which consent shall not be unreasonably withheld. The Agents may not agree to settle any Indemnified Claim
without the prior written consent of the Company, which consent shall not be unreasonably withheld. The Company may participate in such action with its own counsel. The parties hereto acknowledge that the foregoing indemnities shall survive the
resignation or removal of the Escrow Agent or the termination of this Escrow Agreement. 
 10. Fees and Expenses of Escrow Agent. The
Company shall compensate the Escrow Agent for its services under this Agreement in accordance with Schedule A attached hereto and, in addition, shall reimburse the Escrow Agent for all of its reasonable out-of-pocket expenses, including
reasonable attorneys’ fees and expenses. All of the compensation and reimbursement obligations set forth in this Section 10 shall be payable by the Company upon demand by the Escrow Agent. The obligations of the Company under this
Section 10 shall survive any termination of this Agreement and the resignation or removal of the Escrow Agent. 
 11.
Representations and Warranties. Each of the Company, the Trustee and the Escrow Agent represents and warrants to the other parties: 

(i) It is duly organized, validly existing, and in good standing under the laws of the state of its incorporation or
organization, and has full power and authority to execute and deliver this Agreement and to perform its obligations hereunder. 

(ii) This Agreement has been duly approved by all necessary action, including any necessary shareholder or membership approval,
has been executed by its duly authorized officers, and constitutes its valid and binding agreement enforceable in accordance with its terms. 

  
 -7- 

 (iii) The applicable persons designated herein have been duly appointed to act as
its representatives hereunder and have full power and authority to execute and deliver any demand or Joint Written Direction, to amend, modify or waive any provision of this Escrow Agreement and to take any and all other actions as the
Representatives under this Escrow Agreement, all without further consent or direction from, or notice to, it or any other party. 
 12.
Limitations of Liability. 
  

	 	(a)	The Escrow Agent shall have no responsibility or liability to: 

 (i) Take any
action with respect to the Escrow Funds, other than as directed in Sections 3, 4, 5 and 6 of this Agreement; and 

(ii) Institute any proceeding for the collection of any principal and income arising from, or institute, appear in or defend
any proceeding of any kind with respect to, any of the Escrow Funds unless and until it shall have received instructions from the Company given as provided herein to do so and the Company shall have advanced or guaranteed to it funds sufficient to
pay any expenses incident thereto. 
  

	 	(b)	The Agents shall have no responsibility or liability to: 

 (i) Refund any
depreciation in principal of any Escrow Funds, except to the extent such depreciation in principal resulted from gross negligence, bad faith or willful misconduct; 

(ii) The other parties hereto or to anyone else for any action taken or omitted by it, or any action suffered by it to be taken
or omitted, in good faith and in the exercise of its own best judgment, except for its gross negligence, bad faith or willful misconduct. The Agents may rely conclusively and shall be protected in acting upon any order, notice, demand, certificate,
opinion or advice of counsel (including counsel chosen by the Agents), statement, instrument, report or other paper or document (not only as to its due execution and the validity and effectiveness of its provisions, but also as to the truth and
acceptability of any information therein contained) that is believed by the Agents, in good faith, to be genuine and to be signed or presented by the proper person or persons. The Agents shall not be bound by any notice or demand, or any waiver,
modification, termination or rescission of this Agreement or any of the terms hereof, unless evidenced by a written instrument delivered to the Agents signed by the proper party or parties and, if the duties or rights of the Agents are affected,
unless it shall give its prior written consent thereto; and 

  
 -8- 

 (iii) File information returns with the United States Internal Revenue Service
and payee statements with the Company, documenting the taxes payable by the Company, if any, relating to interest earned on the Escrow Funds. 

13. Identifying Information. The Company acknowledges that a portion of the identifying information required herein is being requested
by the Escrow Agent in connection with the USA Patriot Act, Pub.L.107-56 (the “Act”), and the Company agrees to provide any additional information requested by the Escrow Agent in connection with the Act or any similar legislation or
regulation to which Escrow Agent is subject, in a timely manner. 
 14. Consent to Jurisdiction and Venue. In the event that any
party hereto commences a lawsuit or other proceeding relating to or arising from this Escrow Agreement, the parties hereto agree that the United States District Court for the State of New York shall have the sole and exclusive jurisdiction over any
such proceeding. If such court lacks federal subject matter jurisdiction, the parties agree that the state courts of New York shall have sole and exclusive jurisdiction. Any of these courts shall be proper venue for any such lawsuit or judicial
proceeding and the parties hereto waive any objection to such venue. The parties hereto consent to and agree to submit to the jurisdiction of any of the courts specified herein and agree to accept service of process to vest personal jurisdiction
over them in any of these courts. 
 15. Notices. Any request, demand, authorization, direction, notice, consent, waiver or other
document provided or permitted by this Agreement shall be in writing and shall be deemed to have been duly given (a) on the date of delivery, if delivered personally or by facsimile, upon confirmation of receipt, (b) on the first Business
Day following the date of dispatch if delivered by a recognized next-day courier services or (c) on the third Business Day following the date of mailing if delivered by registered or certified mail, return receipt requested, postage prepaid, to
the parties to this Agreement at the following address or to such other address any party to this Agreement shall specify by notice to the other parties: 

(1) if to the Trustee, addressed to it at American Stock Transfer & Trust Company, LLC, Administrative Support, 6201 15th Avenue,
Brooklyn, NY 11219, Attn: Craig Leibell, facsimile at (718) 331-1852, or at any other address previously furnished in writing to the Company and the Escrow Agent in accordance with this Section 15; 

(2) if to the Company, addressed to it at Targacept, Inc., 100 North Main Street, Suite 1510, Winston-Salem, NC 27101, Attn: Mauri K. Hodges,
Chief Financial Officer, facsimile at (336) 480-2107, or at any other address previously furnished in writing to the Trustee and the Escrow Agent by the Company in accordance with this Section 15; or 

  
 -9- 

 (3) if to the Escrow Agent, addressed to it at 2711 Centerville Road, Wilmington, Delaware 19808
Attn: Escrow Administration, facsimile at (302) 636-8666, or at any other address previously furnished in writing to the Trustee and the Company in accordance with this Section 15. 

16. Amendment or Waiver. This Agreement may be changed, waived, discharged or terminated only by a writing signed by the
Representatives and the Escrow Agent. No delay or omission by any party in exercising any right with respect hereto shall operate as a waiver. A waiver on any one occasion shall not be construed as a bar to, or waiver of, any right or remedy on any
future occasion. 
 17. Severability. To the extent any provision of this Agreement is prohibited by or invalid under applicable law,
such provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Agreement. 

18. Governing Law. This Agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York.

 19. Entire Agreement. This Agreement constitutes the entire agreement between the parties relating to the holding, investment and
disbursement of the Escrow Funds and sets forth in their entirety the obligations and duties of Escrow Agent with respect to the Escrow Funds. 

20. Binding Effect. This Agreement, as amended from time to time, shall be binding upon, inure to the benefit of and be enforceable by
the respective successors and assigns of the Company, the Trustee and the Escrow Agent. 
 21. Execution in Counterparts. This
Agreement may be executed in counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same instrument. 

22. Termination. Upon the first to occur of the disbursement of all amounts of the Escrow Funds pursuant to this Agreement or the
disbursement of all amounts of the Escrow Funds into court pursuant to Section 5 hereof, this Agreement shall terminate and Escrow Agent shall have no further obligation or liability with respect to this Agreement or the Escrow Funds.

 23. Savings Clause. As indicated above, the Company intends to establish an escrow arrangement with respect to the Escrow Funds
and not a security arrangement. Notwithstanding the foregoing, if the arrangements under this Agreement are ever characterized or challenged by any court or other party as a security interest or other than an escrow arrangement, to secure its
payment and performance obligations under the Indenture and the Securities, the Company hereby grants to the Trustee a continuing first priority lien and security interest in all right, title, and interest in and to the Escrow Funds, all investment
and securities accounts containing Escrow Funds, and all products and proceeds thereof, whether now existing or hereafter arising (the “Collateral”). 

  
 -10- 

 
The Company authorizes the Trustee to file UCC financing statements naming the Company as debtor and describing the Collateral. The Company agrees that it shall not create or permit liens or
encumbrances against the Collateral. The Company and the Trustee agree that the Trustee shall have all rights and remedies of a “secured party” at law, in equity, and under the Uniform Commercial Code, in addition to all other rights and
remedies under this Agreement. 
 24. Time Is of the Essence. The parties agree that TIME IS OF THE ESSENCE for the performance of
all obligations under this Agreement. 
 25. Mutual Agreement. The parties agree that this Agreement has been negotiated and drafted
among them through mutual agreement and shall be interpreted without preference towards any party. 

  
 -11- 

 IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the date first written
above. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ Mauri K. Hodges

		 	Name: Mauri K. Hodges
		 	Title: VP Finance & Administration & Chief            Financial Officer
	
	AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, Trustee
		
	By:	 	 /s/ Paul Kim

		 	Name: Paul Kim
		 	Title: Assistant General Counsel
	
	Delaware Trust Company, Escrow Agent
		
	By:	 	 /s/ Alan R. Halpern

		 	Name: Alan R. Halpern
		 	Title: Vice President

 [Escrow Agreement] 

  
 -12- 

 SCHEDULE A 
  

	1.	Escrow Funds. 

  

			
	Escrow Funds amount:	 	$37,000,000

 Escrow Funds wiring instructions: Bank Name: PNC Bank; Bank Address: 300 Delaware Avenue, Wilmington, DE
19801; ABA# 031100089; Account Name: Delaware Trust Company; Account Number: 5605012373; OBI: FFC: Targacept, Inc./American Stock Transfer Escrow; 79-2339 
  

	2.	Escrow Agent Fees. 

 WAIVED – up fee payable upon execution of this Escrow Agreement 

$2,500.00 – escrow agent fee payable upon execution of this Escrow Agremeent 

and upon each subsequent annual anniversary date. 
 TRANSACTION
FEES: 
 Wire transfer of fund: $35.00/domestic wire initiated; $75.00/international payment 

Checks Cut: $10.00/check cut 
 1099 Preparation: $12.00/1099
prepared 
 1042-S Preparation: $50.00/per 1042-S 
 Returned
Check: $30.00/returned item 
 An additional annual fee of 15 basis points on the escrow account balance payable in advance may be charged for investments
other than institutional money market funds with which the Escrow Agent has established servicing arrangements. Out-of-pocket expenses, fees and disbursements and services of an unanticipated or unexpected nature are not included in the above
schedule and will be billed at cost. 
  

	3.	Taxpayer Identification Numbers. 

  

	    	Company:
                                     

 

	4.	Investment Instructions  

 BlackRock Temp Fund Cash Management Class (the “Share Class”), an
institutional money market mutual fund for which the Escrow Agent serves as shareholder servicing agent and/or custodian or subcustodian. The parties hereto: (i) acknowledge Escrow Agent’s disclosure of the services the Escrow Agent is
providing to and the fees it receives from BlackRock; (ii) consent to the Escrow Agent’s receipt of these fees in return for providing shareholder services for the Share Class; and (iii) acknowledge that the Escrow Agent has provided
on or before the date hereof a BlackRock Temp Fund Cash Management Class prospectus which discloses, among other things, the various expenses of the Share Class and the fees to be received by the Escrow Agent. 

  
 A-1 

 Exhibit A 

Trustee Redemption Certificate to Escrow Agent 

	
	REDEMPTION CERTIFICATE
	
	To redeem only part of this Security, state the principal amount to be redeemed:
	
	(Insert the other person’s soc. sec. tax ID no.)
	 
	 
	 
	(Print or type other person’s name, address and zip code)
	
	Your Signature:                                
	(Sign exactly as your name appears on the other side of this Security)

 Exhibit B 

Trustee Conversion Certificate to Escrow Agent 

	
	CONVERSION CERTIFICATE
	
	To convert only part of this Security, state the principal amount to be converted:
	
	If you want the stock certificate made out in another person’s name fill in the form below:
	 
	 
	
	(Insert the other person’s soc. sec. tax ID no.)
	 
	(Print or type other person’s name, address and zip code)
	Your
Signature:                                       
                 
	(Sign exactly as your name appears on the other side of this Security)

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