Document:

<PAGE>   1
                                                                    EXHIBIT 10.1

                                 LEASE AGREEMENT

                                     BETWEEN

                           PHARMACIA & UPJOHN COMPANY
                               SUCCESSOR BY MERGER
                          TO ADRIA LABORATORIES, INC.,

                                    LANDLORD

                                      -AND-

                              OPTICON MEDICAL, INC.

                                     TENANT

                                   DATED AS OF

                                 AUGUST 20, 1998

<PAGE>   2

                            INDEX TO LEASE AGREEMENT
                            ------------------------
<TABLE>
<CAPTION>
<S>                                                                                                              <C>
1.       PREMISES...............................................................................................  1

2.       TERM...................................................................................................  2

3.       RENT...................................................................................................  2
         (A)      ANNUAL RENT...................................................................................  2
         (B)      ADDITIONAL RENT...............................................................................  3

4.       SECURITY DEPOSIT.......................................................................................  7

5.       HEAT, VENTILATING AND AIR CONDITIONING.................................................................  8

6.       ELECTRICITY............................................................................................  8

7.       ELEVATOR SERVICE.......................................................................................  9

8.       JANITOR SERVICE......................................................................................... 9

9.       REPAIRS................................................................................................. 9

10.      WATER....................................................................................................9

11.      WINDOW TREATMENTS.......................................................................................10

12.      SERVICE AT UNUSUAL TIME................................................................................ 10

13.      INTERRUPTION OF SERVICE................................................................................ 10

14.      OPERATION OF BUILDING:  RIGHTS RESERVED TO LANDLORD.................................................... 10

15.A     OPERATION OF BUILDING:  TENANT'S OBLIGATIONS........................................................... 11

15.B     OPERATION OF BUILDING:  LANDLORD'S OBLIGATIONS......................................................... 12

16.      TENANT'S OBLIGATIONS ON TERMINATION OF THIS
         AGREEMENT...............................................................................................13

17.      SIGNS AND ADVERTISEMENTS............................................................................... 13

18.      MECHANICS LIENS........................................................................................ 14

19.      INDEMNIFICATION........................................................................................ 14

20.      ASSIGNMENT, SUBLETTING OR RECAPTURE.................................................................... 14

21.      CASUALTY............................................................................................... 15

22.      WAIVER OF CLAIMS AND SUBROGATION....................................................................... 16
</TABLE>

<PAGE>   3

<TABLE>
<CAPTION>
<S>                                                                                                             <C>
23.      USE OF DEMISED PREMISES................................................................................ 16

24.      DEFAULT................................................................................................ 17

25.      BANKRUPTCY OR INSOLVENCY............................................................................... 18

26.      TERMINATION OF LEASES.................................................................................. 18

27.      ABANDONMENT OF DEMISED PREMISES........................................................................ 18

28.      REMOVAL OF PROPERTY FROM DEMISED PREMISES.............................................................. 19

29.      COSTS OF ENFORCEMENT................................................................................... 20

30.      REMEDIES CUMULATIVE.................................................................................... 20

31.      NOTICES................................................................................................ 20

32.      HOLDING OVER, ATTORNMENT, AND LANDLORD'S TITLE......................................................... 20

33.      CONDEMNATION........................................................................................... 21

34.      FLOOR LOAD, NOISE AND VIBRATIONS....................................................................... 22

35.      CARE OF PREMISES....................................................................................... 23

36.      ELECTRICAL REQUIREMENTS................................................................................ 23

37.      QUIET ENJOYMENT........................................................................................ 23

38.      LANDLORD'S RIGHT TO REMEDY DEFAULT..................................................................... 24

39.      LIMITATION ON TENANT'S RIGHT TO TERMINATE                                      ........................ 24

40.      ESTOPPEL CERTIFICATE................................................................................... 24

41.      LIABILITY INSURANCE POLICY............................................................................. 25

42.      CASUALTY INSURANCE..................................................................................... 25

43.      BROKERAGE.............................................................................................. 25

44.      MISCELLANEOUS TAXES.................................................................................... 26

45.      CONDITION OF PREMISES.................................................................................. 26

46.      TENANT DEFINED......................................................................................... 26

47.      REPRESENTATIONS OF LANDLORD                                                                             27
</TABLE>

<PAGE>   4
<TABLE>
<CAPTION>
<S>                                                                                                             <C>
48.      SUBHEADINGS............................................................................................ 27

49.      ADDITIONAL TERMS....................................................................................... 27

50.      HAZARDOUS SUBSTANCE.....................................................................................27

51.      LAW OF OHIO TO GOVERN.................................................................................. 28

52.      SHORT FORM LEASE....................................................................................... 28
</TABLE>

<PAGE>   5

                                 LEASE AGREEMENT
                                 ---------------

                  The parties hereto, Pharmacia & Upjohn Company, successor by
merger to Adria Laboratories, Inc., a Delaware corporation ("Landlord"), and
Opticon Medical, Inc., an Iowa corporation (hereinafter referred to as "Tenant")
as of this 20th day of August, 1998 hereby agree to lease the premises described
on the following terms:

                  1.       PREMISES
                           --------

                  Landlord, subject to the terms and conditions hereof, leases
to Tenant the premises (hereinafter referred to as the "Demised Premises") known
and described as the northeast portion of the First Floor of the North Building
of Dublin Commerce Center, 7001 Post Road, Dublin, Union County, Ohio 43017,
containing approximately 4,100 usable square feet and approximately 4,345
rentable square feet (to be verified during preliminary space planning in
accordance with standards defined by the Building Owners and Managers
Association), together with the common use of four (4) parking spaces per one
thousand (1,000) square feet leased, and the non-exclusive right to use the
common areas. Common areas include, without limitation, the lobby, elevators,
stairwells, sidewalks, access driveways or drives and parking lots. The Demised
Premises are more particularly described in the Demised Premises Floor Plan
attached hereto as Exhibit "1." Hereinafter the North Building, together with
the real estate parcel upon which it sits shall be known as the "Building."

                  Tenant shall have an on-going Right of First Offer for the
remaining space on the First Floor of the North building, and the attached
single-story building during the term of this Lease, including any renewals.
That is, if Landlord has not leased the described space, Tenant may make an
offer for all or part of the described space, upon terms to be negotiated and
agreed upon by the parties, if there is such agreement.

                  All the outside walls of the Demised Premises, any terraces or
roofs adjacent to the Demised Premises, and any space within the walls, floor or
ceiling of the Demised Premises used for shafts, stacks, pipes, conduits, ducts,
the use thereof, as well as access thereto through the Demised Premises for the
purposes of operation, maintenance, and repair, are expressly reserved to
Landlord. Any damage to the Demised Premises occasioned by such operation,
maintenance and repair shall be repaired by Landlord at its sole cost and
expense.

                  The terms "rentable square feet" and "rentable space" are
synonymous and are determined by measuring office space from the glass line on
the outside walls of the building to the inside wall within the office or any
corridor or common area. Rentable area set forth above includes a maximum of
Twelve percent (12.0%) common area factor. The parties agree that at the
commencement of the Lease the common area factor is Six percent (6%) but that it
can increase to a maximum of Twelve percent (12%). Further, that an increase
over Six percent (6%) will be documented by B.O.M.A. standards to Tenant, and
Tenant shall have the right to inspect all relevant documents and reports.

<PAGE>   6

                  Landlord states that the name of the Building at this time is
Dublin Commerce Center, that is street address is 7001 Post Road, Dublin, Ohio
43017, and that the Demised Premises are Suite No. 100.

                  2.       TERM
                           ----

                  (a) The term of this Lease Agreement shall be for a period of
three (3) years commencing on the fifteenth day of September, 1998, and expiring
on the fourteenth day of September, 2001 (unless sooner terminated as provided
herein).

                  (b) Tenant's right to occupy the Demised Premises shall
commence July 24, 1998 or whenever this Lease is executed, whichever is sooner.

                  (c) The Demised Premises are delivered in "AS-IS" condition.
Any and all improvements are the responsibility of the Tenant. Tenant may make
improvements and alterations at Tenant's expense, with all plans and
specifications approved by Landlord. Landlord's approval shall not be
unreasonably withheld.

                  (d) Tenant shall have one (1) renewal option for a period of
three (3) years. The rental rate for the renewal period(s) shall be the then
current-market rate for space in the Demised Premises' submarket, at the time
the renewal notice is given. Tenant shall provide Landlord with at least six
months but not more than twelve (12) months prior written notice of its exercise
of Tenant's renewal option(s). If the parties hereto cannot agree on the rental
rate (not the expense factor) within thirty (30) days after the exercise of the
option by Tenant, this lease will terminate at the end of the primary term.

                   3.      RENT
                           ----

                  (A) ANNUAL RENT. Tenant agrees to pay to Landlord for the
Demised Premises an annual rental of:
<TABLE>
<CAPTION>

===============================================================================================
YEAR                                      ANNUAL NET RENT PER     NET RENT        NET RENT PER
                                          SQ. FT.                 PER YEAR        MONTH
-----------------------------------------------------------------------------------------------
<S>                                      <C>                     <C>             <C>
September 15, 1998 - September 14, 1999   $7.80                   $33,891.00      $2,824.25
-----------------------------------------------------------------------------------------------
September 15, 1999 -September 14, 2000    $8.00                   $34,760.00      $2,896.67
-----------------------------------------------------------------------------------------------
September 15, 2000 - September 14, 2001   $8.20                   $35,629.00      $2,969.08
-----------------------------------------------------------------------------------------------
</TABLE>

together with annual Operating Expenses (defined below) of $5.95 per square foot
(currently, $5.95 times 4,345 = $25,852.75 annually, or $2,154.40 monthly), in
advance, in equal monthly installments (initially $4,978.65) on the fifteenth
day of each calendar month beginning September 15, 1998, without any setoff or
counterclaim whatsoever. These amounts shall hereinafter be called

                                       2
<PAGE>   7

"Base Rent."

                  (B) ADDITIONAL RENT. As used in this Lease Agreement, the term
"Operating Year" shall mean a twelve month period beginning on January 1 and
ending on December 31 of the same calendar year.

                  If in any Operating Year which falls in whole or in part
within the term of this Lease Agreement (or renewal periods, if any) the
Operating Expenses as hereinafter defined per rentable square foot of the
Building should exceed $5.95 per rentable square foot of area therein, Tenant
shall pay additional rent for that Operating Year or for that part of the
Operating Year falling within the term of this Lease Agreement. Operating
Expenses per rentable square foot shall be determined by dividing Operating
Expenses by the total rentable area of the Building as set forth in Exhibit 1
hereto. The excess of Operating Expenses rentable per square foot over $5.95
shall be defined as the Operating Expense Differential. Additional rent payable
by Tenant shall be the Operating Expense Differential times the number of
rentable square feet leased under this Lease Agreement as set forth in Paragraph
1 of this Lease Agreement. Provided, however, Tenant's operating expenses will
be capped at a five percent (5%) increase annually based upon the 1998 base year
of $5.95 per square foot during the initial and any renewal term.

                  It is provided however, that additional rent for any Operating
Year which does not fall entirely within the term of this Lease Agreement shall
be the amount of additional rent computed for that entire Operating Year
multiplied by the fraction created by dividing the number of days in the
Operating Year which fall within the term of this Lease Agreement by 365.

                  Also provided, however, that if the expenses are less than
$5.95 per square foot, Landlord will credit that amount against future rental
payments if any, or if not, Landlord will pay to Tenant the adjustment in cash,
within thirty (30) days.

                  At the commencement of this Lease Agreement and at or prior to
the commencement of any Operating Year during the term hereof, Landlord may
deliver to Tenant a written estimate of any additional rent (such expense being
hereinafter referred to as "Estimated Operating Expense Differential") which may
be due hereunder during the year in which this Lease Agreement commences or for
any such succeeding year as the case may be, whereupon the monthly rental for
such full or partial Operating Year shall be increased by 1/12th of the amount
of the Estimated Operating Expense Differential for the particular year.

                  Statements showing the actual total of Operating Expenses of
the Building and Tenant's proportionate share thereof (hereinafter referred to
as "Statement of Actual Adjustment") shall be delivered by Landlord to Tenant
within a reasonable period of time after the end of any Operating Year in which
Estimated Operating Expenses Differential was paid by Tenant or due Landlord
under the provisions hereof. Within thirty (30) days after the delivery by
Landlord to Tenant of such Statement of Actual Adjustment, Tenant shall pay to
Landlord the amount by which the actual adjustment exceeds the amount paid by
Tenant as Estimated Operating Differential during said previous Operating Year,
subject in any event to a five (5%) percent increase cap or Landlord shall
credit Tenant the amount by which the Estimated Operating Expense Differential
exceeded the Statement of Actual Adjustment.

                                       3
<PAGE>   8

                  i) "Operating Expense" is defined as the expense incurred by a
reasonable and prudent operator of a first class office building in Columbus,
Ohio and shall include all costs of operation, maintenance and repair of the
Building.

                  "Operating Expense" shall include, but not be limited to, the
following expenses of Landlord with respect to the Building: all real estate
taxes and assessments, general or special, ordinary or extraordinary, payroll
taxes, federal and state unemployment taxes and social security taxes prorated
for the amount of time employees accrually worked on the Building; insurance,
including but not limited to boiler, water damage, fire and extended coverage,
casualty, liability, workmen's compensation; water and sewer charges; cost of
wage and salaries of operating personnel including welfare, retirement,
vacations and other compensation and fringe benefits prorated for amount of time
employees accrually worked on the Building; management fees; auditor's fees;
legal fees; materials and supplies, including charges for telephone, telegraph,
postage, stationery supplies and other materials and expenses required for
routine operation of the Building operation office; repairs to and maintenance
of routine operation of the Building, including cost of materials, supplies,
tools and equipment used in connection therewith, costs incurred in connection
with the operation, inspection and servicing, including outside maintenance and
janitorial service contracts, and of security personnel provided for Building
and Landlord's area only and not the Demised Premises, of elevator, electrical,
plumbing, heating, air conditioning and mechanical equipment and the cost of
materials, supplies (including lamps, bulbs, starters and ballasts used in
Demised Premises), tools and equipment used in connection therewith; cost of
services (including electricity, steam, gas, water and other utilities) for the
operation and maintenance of the Building, and all such other expenses and costs
necessary or desirable to be incurred for the purpose of operating and
maintaining the Building in good and workmanlike condition, but excluding
Landlord's cost of electricity and other services to the extent that such
services and electricity are sold to and separately paid for by Tenants, costs
incurred by Landlord for Tenants' alterations and depreciation and costs of
capital replacements and improvements; provided, however, that Operating
Expenses shall also include the annual amortization (over the anticipated useful
life) of the cost of a capital improvement, plus any interest or financing
charges thereon, falling within any of the following categories: (a) a
labor-saving or energy-saving device or improvement which eliminates any other
component of Operating Expenses or which reduces any such Operating Expense from
the costs that would have been incurred had such device or improvement not been
installed, but only to the extent Operating Expenses are decreased; (b) an
installation or improvement required by reason of any law, ordinance or
regulation, which requirement did not exist on the date of this Lease Agreement
and is generally applicable to similar office buildings; (c) an installation or
improvement which directly enhances safety of Tenants in the Building generally.

                  "Real Estate Taxes" as used herein shall be all taxes,
including state equalization factors, if any, and assessments, special or
otherwise, exclusive of penalties or discounts, levied upon or with respect to
the Building, including the Demised Premises, imposed by any federal, state or
local government agency, including any use, occupancy, excise or other like
taxes (other than general income taxes on rent or other income from the Building
computed in the case of a graduated tax, as if Landlord's rent and other income
from the Building was Landlord's sole taxable income).

                                       4
<PAGE>   9

                  Real Estate Taxes shall include the expense of contesting the
amount of validity of any such taxes, charges or assessments, such expense to be
applicable to the period of the items contested. Real Estate Taxes shall not,
however, include income, franchise, capital stock, estate or inheritance taxes.
For purposes of this Lease Agreement, Real Estate Taxes for any year shall be
those taxes the last timely payment date for which occurs on or before the last
day of the year, regardless of when accrued. In case of special taxes or
assessments payable in installments, only the amount of the installment(s) the
last timely payment day for which occurs on or after the first day and on or
before the last day of such year shall be included in Real Estate Taxes for that
year.

                  Landlord shall retain the sole right to participate in any
proceedings to establish or contest the amount of Real Estate Taxes. If by
reason of complaint against valuation, protest of tax rates or otherwise, Real
Estate Taxes for any calendar year are affected in such a way as would result in
a rent increase or decrease hereunder, the Real Estate Taxes for resulting
increased or decreased rent, less the expense incurred in effecting any
reduction, shall be paid simultaneously with or applied as a credit against the
rent next becoming due.

                  ii) In the event of a clerical error or the discovery of new
facts by Landlord or Landlord's accountants, which causes the Statement of
Actual Adjustment for any period to increase or decrease, upon notice by
Landlord to Tenant of the new, revised Statement of Actual Adjustment for such
Operating Year, the new, revised adjusted additional operating costs shall apply
and any deficiency or overpayment, as the case may be, shall be paid by Tenant
or paid to or taken as a credit by Tenant.

                  iii) If Tenant shall question in writing any such notice of
Statement of Actual Adjustment (or revised notice thereof), and the question is
not amicably settled between Landlord and Tenant within thirty (30) days after
said notice of Statement of Actual Adjustment (or revised notice thereof) has
been given, Landlord shall, during the sixty (60) days next following the
expiration of the first mentioned thirty (30) day period, employ an independent
certified public accountant reasonably satisfactory to Tenant to audit the Real
Estate Taxes and/or the Operating Expenses and said notice of Statement of
Actual Adjustment (or revised notice thereof). The determination of such
accountant shall be final, conclusive and binding upon Landlord and Tenant. The
amounts of individual items constituting the Operating Expenses is confidential;
and while Landlord shall keep and make available to such accountant and/or
Tenant all records in reasonable detail, and shall permit such accountant and/or
Tenant to examine and audit such of Landlord's records as may reasonably be
required to verify such notice of Statement of Actual Adjustment (or revised
notice thereof) at reasonable times during business hours, Landlord shall not be
required to (and the accountant and/or Tenant shall not be permitted to)
disclose to any person, firm or corporation, any such details provided that
Tenant may disclose to Tenant's attorneys and accountants and if litigation
results (it being the intent of the parties that such accountant shall merely
certify to Landlord and to Tenant the correct amount of Tenant's Statement of
Actual Adjustment). Any change in Statement of Actual Adjustment required by
such accountant's determination shall be made within thirty (30) days after such
determination has been rendered. The expenses involved in such determination
shall be borne by Landlord, unless the results of such audit disclose that
Landlord's notice of Statement of Actual Adjustment was substantially correct no
more than five (5%) percent wrong, in which case Tenant shall reimburse Landlord
for the reasonable costs of such audit, which reimbursement shall be forthwith
due upon demand for same by Landlord and shall be deemed to be additional
operating costs hereunder. If Tenant does not, in writing, question any notice
of Statement of Actual Adjustment within thirty (30) days after such

                                       5
<PAGE>   10

notice has been given, Tenant shall be deemed to have approved and accepted such
Statement of Actual Adjustment.

                  No decrease in Real Estate Taxes and/or Operating Expenses
shall reduce Tenant's rent below the annual base rental as set forth in
Subparagraph 3(a) hereof.

                  All costs and expenses which Tenant assumes or agrees to pay
to Landlord pursuant to this Lease Agreement shall be deemed additional rent
and, in the event of non-payment thereof, Landlord shall have all the rights and
remedies herein provided for in case of non-payment of rent.

                  Notwithstanding any provision in this Section 3(B) to the
contrary, Tenant shall not be responsible to make any additional rent payment
relating to increased Operating Expenses for the period August 20, 1998 through
and including September 14, 1999.

                  (C) If any installment of Base Rent or Additional Rent or any
other rent provided for in this Lease Agreement, or any part thereof or Rider
thereto, is not paid within the applicable period specified in Paragraph 24 of
this Lease Agreement, Tenant shall pay to Landlord a late charge of five percent
(5%) of the amount of such installment, and, in addition, such unpaid
installment shall bear interest at the rate per month of 1-1/2% from the date
such installment became due and payable to the date of payment thereof by
Tenant; provided, however, that nothing herein contained shall be construed or
implemented in such a manner as to allow Landlord to charge or receive interest
in excess of the maximum legal rate then allowed by law. Such late charge and
interest shall constitute additional rent hereunder due and payable within the
next monthly installment of Base Rent.

                  (D) All payments of rent or any other moneys owing from Tenant
to Landlord shall be made at the office of Adena Realty Advisors, 57 East Wilson
Bridge Road, Worthington, Ohio 43085, or such other places as may from time to
time be designated by Landlord.

                  4. SECURITY DEPOSIT
                     ----------------

                  As security for the performance and observance by Tenant of
all of its obligations under the terms, conditions and covenants of this Lease
Agreement, Tenant has deposited with Landlord the sum of Four Thousand Nine
Hundred Seventy-Eight and 65/100 Dollars ($4,978.65) which sum shall be held by
Landlord as a security deposit during the term of this Lease Agreement. If
Tenant performs and observes all of the terms, conditions and covenants of this
Lease Agreement which are required to be performed and observed by it, Landlord
shall return the security deposit, or balance thereof then held by Landlord,
without interest, to Tenant within thirty (30) days after the Expiration Date or
after Tenant surrenders possession of the Demised Premises, whichever is later.
In the event of a default by Tenant in the payment of rent or the performance or
observance of any of the other terms, conditions, or covenants of this Lease
Agreement after notice and the expiration of all applicable cure periods without
cure, then Landlord may, as its option and without notice, apply all or any part
of the security deposit in payment of such rent or to cure any other such
default; and if Landlord does so, Tenant shall upon request deposit with
Landlord the amount so applied so that Landlord will have on hand at all times
during the term of this Lease Agreement the full amount of the security deposit.
Landlord shall not be required to hold the security deposit as a separate
account, but may commingle it with Landlord's other funds. In the event of a
sale or lease of the land and Building of which the Demised Premises are a part,
Landlord shall have the right to

                                       6
<PAGE>   11

transfer the security deposit to its purchaser or lessee and Landlord shall
thereupon be released by Tenant from all responsibility for the return of such
deposit, which such purchaser or lessee shall covenant and agree to do; and
Tenant agrees to look solely to the new purchaser or lessee for the return of
such deposit. In the event of an assignment of this Lease Agreement by Tenant,
the security deposit shall be deemed to be held by Landlord as a deposit made by
the assignee, and Landlord shall have no further responsibility for the return
of such deposit to the assignor.

                  5. HEAT, VENTILATING AND AIR CONDITIONING
                     --------------------------------------

                  Landlord agrees to furnish heating, ventilating and air
conditioning, to provide a temperature and humidity condition required in
Landlord's judgment for comfortable occupancy of the Demised Premises, and
Tenant shall pay Landlord therefor, without mark-up, as a part of additional
rent set forth in Section 3., Subsection (b) of this Lease. Tenant promises to
use this, and all utility services, prudently. Whenever heat generating machines
or equipment are used in the Demised Premises which may affect the temperature
otherwise maintained by the air conditioning system, Landlord reserves the
right, at its option, to require Tenant to install supplementary air
conditioning equipment in the Demised Premises, and the cost of such
installation shall be paid by Tenant to Landlord within 15 days after being
billed therefor, and the cost of operation and maintenance of said supplementary
equipment shall be paid by Tenant to Landlord on the monthly rent payment dates
at such rates as may be agreed upon but in no event at a rate less than
Landlord's actual cost therefore for labor, steam, electricity and water.

                  6. ELECTRICITY
                     -----------

                  Landlord agrees to provide electrical service in the Building,
and Tenant shall obtain all such service used in the Demised Premises from
Landlord and pay Landlord therefor, without mark-up, as a part of additional
rent set forth in Section 3., Subsection (B) of this Lease. Tenant agrees not to
install or connect any large business machines, X-rays or other heavy electrical
equipment of any type to the electrical distribution system of the Building
without Landlord's prior written consent so as not to overtax said system to the
detriment of the Building or of other Tenants. At Landlord's option, any such
equipment that is overtaxing the system based upon a review and the review of an
electrical engineer selected and paid for by Landlord but reasonably acceptable
to Tenant, or requires greater consumption of electricity than typical for
general office use may be sub-metered and Tenant agrees to pay the cost of
installing such sub-meter, as well as all electricity recorded through such
sub-meter during the term of this Lease. All charges from such sub-meter shall
be invoiced periodically and shall be due and paid in the same manner as base
rent.

                  7. ELEVATOR SERVICE
                     ----------------

                  Landlord agrees to provide passenger elevator service in
common with others when the building is open, normally daily from 7:00 a.m. to
6:00 p.m., Saturdays from 8:00 a.m. to 12:00 noon, Sundays and holidays excepted
and to tenants with pass keys at all other times. Landlord agrees to provide
freight elevator service in common with others which service Tenant shall
arrange with the property manager.

                                       7
<PAGE>   12

                  8. JANITOR SERVICE
                     ---------------

                  Landlord agrees to provide customary janitorial service five
(5) evenings per week in and about the Demised Premises, Saturdays, Sundays and
holidays excepted. The janitorial service shall be similar to that provided to
tenants in other Class A office buildings located in Dublin, Ohio. Tenant shall
not provide any janitor service without Landlord's written consent, which
consent shall not be unreasonably withheld in which event such janitor service
shall be subject to the Landlord's supervision but at the Tenant's sole cost and
responsibility.

                  9. REPAIRS
                     -------

                  Landlord agrees to make all usual and customary repairs to the
Demised Premises, excluding repairs to any special treatment of walls,
partitions, floors or ceiling made by or at the request of Tenant and excluding
repairs made necessary as a result of misuse or neglect by Tenant. Landlord
agrees to repair and maintain the common area of the building.

                  10. WATER
                      -----

                  Landlord agrees to provide water from City of Columbus mains
for drinking, lavatory and toilet purposes drawn through fixtures installed by
Landlord.

                  11. WINDOW TREATMENTS
                      -----------------

                  Any Tenant's treatment to windows must be approved in writing
by Landlord prior to installation, which approval shall not be unreasonably
withheld but in all cases must conform to building standards.

                  12. SERVICE AT UNUSUAL TIME
                      -----------------------

                  Should Tenant require cleaning service, heating, ventilating,
air conditioning and/or elevator service on days or hours other than those
specified in Paragraph 7 or 8 of this Lease Agreement, Landlord shall, upon
reasonable advance notice by Tenant, furnish such additional service and Tenant
agrees to pay to Landlord, within ten (10) days after being billed therefor, as
additional rent, Landlord's cost of labor, materials and utilities supplied in
providing such additional service, it being agreed that said payment and said
costs shall be excluded from Operating Expense.

                  13. INTERRUPTION OF SERVICE
                      -----------------------

                  The Landlord does not warrant that any of the services above
mentioned will be free from interruptions caused by war, insurrection, civil
commotion, riots, acts of God or the enemy or Government action, repairs,
renewals, improvements, alterations, strikes, lockouts, picketing, whether legal
or illegal, accidents, inability of Landlord to obtain fuel or supplies, or any
other causes or causes beyond the reasonable control of the Landlord. Any such
interruption of service shall never be deemed an eviction or disturbance of the
Tenant's use and possession of the premises or any part thereof, or render the
Landlord liable to the Tenant for damages, or relieve the Tenant from
performance of the Tenant's obligations under this Lease Agreement. Although
Landlord intends to and shall operate a first class office building, the quality
and adequacy of all services furnished shall be determined by Landlord in its
reasonable discretion. The Landlord shall not be

                                       8
<PAGE>   13

liable for any loss or damage or expense which Tenant may sustain or incur if
either the quantity or character of electrical service, water service or gas
service is changed or made unavailable to Tenant or unsuitable for its
requirements by reason of the requirements or actions of the public utility
company supplying electric current to the Building or for any reason not
attributable to Landlord.

                  14. OPERATION OF BUILDING: RIGHTS RESERVED TO LANDLORD
                      --------------------------------------------------

                  Landlord reserves the right to do any of the following:

                  (a) To change the name or street address of the Building
without notice or liability of the Landlord to the Tenant.

                  (b) To install and maintain a sign or signs on the exterior of
the Building.

                  (c) To designate all sources furnishing vending equipment,
painting of the premises, sign painting and lettering, ice, drinking water,
towels and toilet supplies used on the premises.

                  (d) During the last ninety (90) days of the term or any part
thereof, if during that time the Tenant vacates the Demised Premises, to
decorate, remodel, repair, alter or otherwise prepare the premises for
re-occupancy.

                  (e) To constantly have pass keys to the Demised Premises.
Landlord acknowledges, as more fully hereafter stated, that Tenant will be using
a portion of the Demised Premises for research and development. Tenant,
therefore, will be developing trade secrets and work product in the Demised
Premises. Landlord will use reasonable efforts to ensure that Landlord's
personnel who enter the Demised Premises outside of Tenant's business hours by
use of such pass key shall not divulge to anyone any information which such
personnel may gain during such entry, but that all such information shall be
held in highest confidence. Such personnel shall not photograph or photocopy any
of Tenant's property in the Demised Premises and shall not remove any of such
property from the Demised Premises unless an emergency situation exists.

                  (f) To grant to anyone the right to conduct any lawful
business or undertaking in the Building consistent with applicable zoning
ordinances.

                  (g) To exhibit the Demised Premises to others.

                  (h) To take any and all measures, including inspections,
repairs, alterations, additions and improvements to the Demised Premises or to
the Building, as may be necessary or desirable for the safety, protection or
preservation of the Demised Premises or the Building or the Landlord's
interests, or as may be necessary or desirable. The Landlord may enter upon the
Demised Premises and, upon reasonable notice and during Tenant's business hours,
may exercise any or all of the foregoing rights hereby reserved without being
deemed guilty of an eviction or disturbance of the Tenant's use or possession
and without being liable in any manner to the Tenant. The Landlord will use its
best efforts to prevent any unnecessary inconvenience to Tenant or the Tenant's
business.

                  This provision shall not limit the rights of the Landlord
under the law in any manner

                                       9
<PAGE>   14

and the foregoing shall not be deemed to be exclusive list of the rights of the
Landlord.

                  15.A OPERATION OF BUILDING: TENANT'S OBLIGATIONS

                  Tenant agrees to do or perform all of the following:

                  (a) Observe the rules and regulations hereto annexed as
Exhibit "15," and such further rules and regulations as from time to time may be
put in effect by Landlord for the general safety, comfort and convenience of
Landlord, occupants and tenants of the Building, provided that such rules and
regulations shall not unreasonably interfere with the operation of Tenant's
business. Any failure by Landlord to enforce any rules and regulations against
either Tenant or any other Tenant in the Building shall not constitute a waiver
thereof.

                  (b) Give Landlord, its agents and employees, its mortgagees
and any other person or persons authorized by Landlord, access to the Demised
Premises at all reasonable times, after reasonable notice and during normal
business hours, without charge or diminution of rent, to enable Landlord and/or
the others herein before mentioned to examine the same and to make such repairs
as Landlord may reasonably deem advisable. Except as expressly provided
otherwise in this Lease Agreement, there shall be no allowance to Tenant or
diminution of rent and no liability on the part of Landlord by reason of
inconvenience, annoyance or injury to business arising from the making of any
repair in or to any portion of the Building or Demised Premises or in and to the
fixtures, appurtenances and equipment thereof unless caused by the negligence or
willful misconduct of Landlord, its agents, employees, mortgagees or attorneys
authorized by Landlord to enter the Demised Premises.

                  (c) Keep the Demised Premises in good order and condition,
make all repairs thereto which are not Landlord's obligations pursuant to
Paragraph 9 of this Lease Agreement, and commit no waste on the Demised Premises
or the Building.

                  (d) Not overload, damage or deface the Demised Premises or do
any act to bring or keep anything thereon which may make void or voidable any
insurance on the Demised Premises or the Building or which may render an
increase or extra premium payable for insurance.

                  (e) Not make any alteration of or addition to the Demised
Premises without the written approval of Landlord, which approval shall not be
reasonably withheld.

                  Tenant's obligations under this Paragraph 15 to do or not to
do a specified act shall extend to and include Tenant's obligations to see to it
that Tenant's employees, invitees and agents shall do or shall not do such acts,
as the case may be.

                  15.B OPERATION OF BUILDING: LANDLORD'S OBLIGATIONS
                       ---------------------------------------------

                  Landlord agrees to keep the Common Areas of the Building, both
interior and exterior, in a first class condition, similar to that or comparable
to that of others in the Dublin area. Landlord's obligations hereunder shall
include, but shall not be limited to, landscaping, planting, mowing, yard waste
removal and sprinkling; snow and ice removal from the sidewalks, parking lots
and entrances to the Building; paving, repaving and striping the parking lots as
necessary; and providing a reasonable amount of exterior lighting.

                                       10
<PAGE>   15

                  16. TENANT'S OBLIGATIONS ON TERMINATION OF THIS LEASE
                      -------------------------------------------------
                      AGREEMENT
                      ---------

                  Upon the termination of this Lease Agreement in any manner
whatsoever, Tenant shall remove Tenant's goods and effects and those of any
other persons claiming under Tenant, and quit and deliver up the Demised
Premises to Landlord peaceably and quietly in as good order and condition as the
same are now, or hereafter may be improved by Landlord or Tenant, reasonable use
and wear thereof, casualty loss and repairs which are Landlord's obligations
excepted. Tenant reserves the right to remove any and all installations made by
Tenant at Tenant's expense, including without limitation cupboards, cabinets,
built-in bookshelves, floor coverings and light fixtures, except that Tenant
shall not demolish any walls built by Tenant. Any damage to walls, floors or
ceilings will be repaired by or paid for by Tenant. Goods and effects not
removed by Tenant at the termination of this Lease (or within forty-eight (48)
hours after a termination by reason of Tenant's default) shall be considered
abandoned and Landlord may dispose of the same as it deems expedient, but Tenant
shall promptly upon demand reimburse Landlord for any expenses incurred by
Landlord in connection therewith. All alterations, installments, additions,
improvements and floor covering made and installed for Tenant by Landlord at
Landlord's expenses shall remain Landlord's property, whether movable or not,
and Tenant shall be responsible for the maintenance thereof, normal wear and
tear and casualty loss and repairs which are Landlord's responsibility excepted,
and Tenant shall not remove said property without written consent of Landlord.

                  17.      SIGNS AND ADVERTISEMENTS
                           ------------------------

                  (a) Tenant agrees that it shall not place signs,
advertisements or notices on the outside or inside walls, windows, doors or roof
of the Building or on the Demised Premises except as approved in writing by
Landlord with respect to the lettering, size, color, style, location and text of
any such sign which approval shall not be unreasonably withheld.

                  (b) Within six (6) months of the commencement date of this
Lease, Landlord shall, at its expense, install exterior signage identifying the
Building as the "Dublin Commerce Center", which signage shall either be affixed
to the Building or a free-standing monument sign, subject to and conditioned on
Landlord's securing the approval of the City of Dublin thereto.

                  (c) Landlord shall, at its costs, provide a directory in the
Building's lobby identifying the Tenant and the Demised Premises.

                  18. MECHANICS LIENS
                      ---------------

                  Tenant agrees that it will at its own expense, cause to be
discharged or bonded off within sixty (60) days of notice thereof, any
mechanic's lien filed against the Demised Premises or the Building for work
claimed to have been done for, or materials claimed to have been furnished to,
Tenant.

                                       11
<PAGE>   16

                  19. INDEMNIFICATION
                      ---------------

                  Tenant shall indemnify Landlord against all liabilities,
expenses, and losses incurred by Landlord as a result of (a) failure by the
Tenant to perform any covenant required to be performed by the Tenant hereunder;
(b) any accident, injury, or damage which shall happen in or about the Demised
Premises unless such accident, injury, or damage has been caused by the
negligence or intentional act of the Landlord, Landlord's employees, agents, or
contractors; (c) Tenant's failure to comply with any governmental authority; and
(d) Tenant causing any mechanic's lien, or security agreement, filed against the
leased Premises, any equipment therein, or any materials used in the
construction or alteration of any building or improvement thereon.

                  20. ASSIGNMENT, SUBLETTING OR RECAPTURE
                      -----------------------------------

                  Tenant will not sell, assign, mortgage, or transfer its
interest under this Lease Agreement, sublet the Demised Premises or any part
thereof, or allow any transfer hereof, or any lien upon the Tenant's interest by
operation of law, without the prior written consent of the Landlord which
consent shall not be unreasonably withheld except Tenant shall have the right to
assign the Lease in its entirety or to sublease all or any portion of the
Premises without the permission of the Landlord to (a) any entity resulting from
a merger or consolidation with Tenant; (b) any entity succeeding to the business
and assets of Tenant; and (c) any subsidiary or affiliate of Tenant. Affiliate
shall mean any partnership, corporation, unincorporated association, joint
venture or other entity which is controlled by or is under common control with
Tenant. A sublease or assignment to any entity other than the above described
will require the prior written consent of Landlord as provided herein. Should
Tenant desire to sublet the premises or any part thereof, Tenant shall by
written notice so advise Landlord of its request to sublet on a stated date,
(which shall not be less than ninety (90) days nor more than one hundred twenty
(120) days after date of Tenant's notice) and in such event, Landlord shall have
the right, to be exercised by giving written notice to Tenant within thirty (30)
days after receipt of Tenant's notice, to recapture the space described in
Tenant's notice and such recapture shall, if given, cancel and terminate this
Lease with respect to the space therein described as of the date stated in
Tenant's notice. Tenant's notice shall state the name and address of the
proposed subtenant and a true and complete copy of the proposed sublease shall
be delivered to Landlord with said notice. If Tenant's notice shall cover all of
the space hereby demised, and Landlord shall give the aforesaid recapture notice
with respect thereto, the term of this Lease Agreement shall expire and end on
the date stated in Tenant's notice as fully and completely as if that date had
been herein definitely fixed for the expiration of the term. If, however, this
Lease Agreement be canceled pursuant to the foregoing with respect to less than
the entire premises, the rental and the escalation percentage herein reserved
shall be adjusted on the basis of the number of square feet retained by Tenant
in proportion to the rent and escalation percentage reserved in this Lease
Agreement, and this Lease Agreement as so amended shall continue thereafter in
full force and effect as to the remaining portion of the Demised Premises. In
addition, if this Lease Agreement be canceled pursuant to the foregoing with
respect to less than the entire premises, Tenant shall forthwith reimburse
Landlord for the actual cost to Landlord of making all repairs and alterations,
including partitions and other requirements, necessary to close off the
recaptured space from the remaining portion of the premises. If Landlord upon
receiving Tenant's notice with respect to any such space, shall not exercise its
right to cancel as aforesaid, Landlord shall, by giving written notice to Tenant
within the thirty (30) days after receipt of such notice, either consent to or
decline to consent to such requested sublease or assignment, provided that in
such event Landlord will not unreasonably withhold its consent to Tenant's
subletting the space covered by its notice or

                                       12
<PAGE>   17

assigning this Lease.

                  Any subletting (or assignment) hereunder shall not release or
discharge Tenant of or from any liability, whether past, present or future,
under this Lease Agreement, and Tenant shall continue fully liable thereunder.
The subtenant or subtenants or assignee shall agree to comply with and be bound
by all the terms, covenants, conditions, provisions and agreements of this Lease
Agreement to the extent of the space sublet or assigned, and Tenant shall
deliver to Landlord promptly after execution, an executed copy of each such
sublease or assignment and an agreement of compliance by each such subtenant or
assignee.

                  Any sale, assignment, mortgage, transfer, or subletting of
this Lease Agreement which is not in compliance with the provisions of this
Paragraph 20 shall be void and of no effect.

                  The Landlord may assign this Lease Agreement and shall not be
liable for obligations thereafter accruing hereunder; provided that the
Landlord's assignee shall assume the Landlord's obligations hereunder accruing
on or after the date of assumption.

                  21. CASUALTY
                      --------

                  In case of damage to the Demised Premises or the Building by
fire or other casualty, Tenant shall give immediate notice to Landlord, who
shall thereupon cause the damage to be repaired with reasonable speed at the
expense of Landlord subject to delays which may arise by reason of adjustment of
loss under insurance policies and for delays beyond the reasonable control of
Landlord, and to the extent that the Demised Premises are rendered unrentable,
the rent shall proportionately abate, except in the event such damage resulted
from or was contributed to by the act, fault or neglect of Tenant, Tenant's
employees, or invitees or agents, in which event there shall be no abatement of
rent. In the event that such damage to the Demised Premises or the Building
cannot be or is not repaired within 180 days from the date of such casualty,
either the Landlord or Tenant may terminate this Lease by giving the other
written notice of such termination and the rent shall be adjusted to the date of
such damage and the Tenant shall thereupon promptly vacate the Demised Premises.

                  22. WAIVER OF CLAIMS AND SUBROGATION
                      --------------------------------

                  (a) Tenant agrees that Landlord, its building manager and
Landlord's and the building manager's respective officers and employees shall
not be liable to Tenant for any damage to or loss of personal property located
in the Demised Premises or for injuries to persons unless such damage, loss or
injury is the result of negligence of Landlord, its building manager, or its
officers or employees, and Landlord and its building manager and its officer and
employees shall not be liable to Tenant for any such damage, loss, or injury,
whether or not the result of their negligence, to the extent Tenant is
compensated therefore by Tenant's insurance.

                  (b) Landlord and Tenant release each other, their agents,
employees and invitees from any claims for damage or destruction to the
Premises, or to the contents thereof, belonging to either, or business or rent
interruption, or injury and/or death of any person or persons which is caused by
fire or other peril to the extent that the insured is compensated by insurance,
whether due to negligence of either of them or otherwise, when permitted by the
applicable policies of insurance.

                                       13
<PAGE>   18

                  23. USE OF DEMISED PREMISES
                      -----------------------

                  Tenant shall not use or occupy or permit the Demised Premises
to be used or occupied, nor do or permit anything to be done in or on the leased
property:

                  (a) which will in any way violate any certificate of occupancy
affecting the Demised Premises or the Building;

                  (b) which will cause or be likely to cause structural damage
to the Building or any part thereof;

                  (c) which will violate any present or future laws or
regulation of any governmental authority;

                  (d) which will make void or voidable any insurance then in
force with respect to the Demised Premises;

                  (e) which shall increase the rate of fire and/or casualty
insurance in the Building over that in effect prior to the execution of this
Lease Agreement;

                  (f) which through the use of loud speakers, phonographs,
television, or radio broadcasts shall create noise which may be heard outside
the Demised Premises and which could be reasonably considered objectionable by
Landlord and/or other Tenants;

                  (g) which will interfere with the reception or transmission of
television or radio signals or other transmission in the Building;

                  (h) which will constitute a public or private nuisance

                  Landlord acknowledges and agrees that Tenant, in addition to
using the Demised Premises for office use, will also be using a substantial
portion of the Demised Premises for research and development of medical devices.
This research and development may entail use of different equipment than that
used in general office use and may entail Tenant having to handle certain
substances and products in strict accordance with all applicable law. Landlord
covenants and agrees that, anything in this Lease to the contrary
notwithstanding, Tenant's use of the Demised Premises for that purpose and the
use of the additional machinery and equipment shall in no way at any point in
time constitute a default hereunder. Provided, however, that (i) such research
and development activities shall not cause an unusually large number of persons
to enter the Building or the Demised Premises, (ii) such additional machinery
and equipment shall not create noise, odor or vibration levels that are
objectionable to Landlord or other tenants in the Building, and (iii) such
additional machinery and equipment shall not use a level of energy which exceeds
normal office use.

                                       14
<PAGE>   19

                  24. DEFAULT
                      -------

                  If the Tenant defaults in the payment of rent, or in payment
of any sum deemed to be additional rent under this Lease Agreement and the
Tenant does not cure such default within ten (10) days after notice thereof
(Landlord not being required to give such notice more than once per year), or if
the Tenant defaults in the prompt and full performance of any other provision of
this Lease Agreement, and if the Tenant does not cure the default within thirty
(30) days after the written demand by Landlord that the default be cured, unless
if the default cannot reasonably be cured within thirty (30) days, Tenant fails
to commence such cure within thirty (30) days and/or fails thereafter to
diligently work to effect such cure, or unless the default involves a hazardous
condition, which shall be cured forthwith upon the Landlord's demand, or if the
leasehold interest of the Tenant be levied upon under execution or be attached
by process of law, or if the Tenant make an assignment for the benefit of
creditors, or if a receiver be appointed for any property of the Tenant and not
discharged within sixty (60) days, or if the Tenant abandons the Demised
Premises, for more than thirty (30) days, then and in any such event the
Landlord may, if the Landlord so elects but not otherwise, either forthwith
terminate this Lease Agreement and the Tenant's right to possession of the
Demised Premises, or without terminating this Lease Agreement, forthwith
terminate the Tenant's right to possession of the Demised Premises.

                  25. BANKRUPTCY OR INSOLVENCY
                      ------------------------

                  If any voluntary or involuntary petition or similar pleading
under any section or sections of any bankruptcy act shall be filed by or against
the Tenant, or any voluntary or involuntary proceeding in any court or tribunal
shall be instituted to declare the Tenant insolvent or unable to pay the
Tenant's debts, and in the case of any involuntary petition or preceding, the
petition or proceeding is not dismissed within sixty (60) days from the date it
is filed, the Landlord may elect, but is not required, and with or without the
notice of such election, and with or without entry or other action by the
Landlord, to forthwith terminate this Lease Agreement, and, notwithstanding any
other provision of this Lease Agreement, the Landlord shall forthwith upon such
termination be entitled to recover damages in an amount equal to the then
present value of the rent specified in Paragraph 2 of this Lease Agreement for
the residue of the stated term hereof less the present value of the fair rental
value over the same time.

                  26. TERMINATION OF LEASES
                      ---------------------

                  Upon any termination of this Lease, whether by lapse of time
or otherwise, or upon any termination of the Tenant's rights to possession
without termination of the Lease Agreement, the Tenant shall surrender
possession thereof to the Landlord, and the Tenant hereby grants to the Landlord
full and free license to enter into and upon the Demised Premises in such event
with or without process of law and to repossess the Landlord of the Demised
Premises as of the Landlord's former estate and to expel or remove the Tenant
and any others who may be occupying or within the Demised Premises and to remove
any and all property therefrom, using such force as may be necessary, without
being deemed in any manner guilty of trespass, eviction, or forcible entry or
detainer, and without relinquishing the Landlord's rights to rent or any other
right given to the Landlord hereunder or by operation of law.

                                       15
<PAGE>   20

                  27. ABANDONMENT OF DEMISED PREMISES
                      -------------------------------

                  If the Tenant abandons the Demised Premises for more than
thirty (30) days or otherwise entitles the Landlord so to elect, and the
Landlord elects to terminate the Tenant's right to possession only, without
terminating the Lease Agreement, the Landlord may, at the Landlord's option
enter into the Demised Premises, remove the Tenant's signs and other evidence of
tenancy, and take and hold possession thereof as provided in Paragraph 26 of
this Lease Agreement, without such entry and possession terminating the Lease
Agreement or releasing the Tenant, in whole or in part, from the Tenant's
obligations to pay the rent hereunder for the full term. Upon and after entry
into possession without termination of the Lease Agreement, the Landlord shall
use its best efforts to re-rent the Demised Premises (or such part thereof as
Landlord deems proper) for the account of the Tenant to any persons, firm or
corporation other than the Tenant for such rent, for such time and upon such
terms as the Landlord in the Landlord's commercially reasonable discretion shall
determine, and the Landlord shall not be required to obtain consent of the
Tenant or to observe any instructions given by the Tenant about such re-renting.
Tenant expressly agrees that, in the event Landlord shall enter into possession
without terminating this Lease Agreement, Landlord need not give preferential
treatment to the leasing of the Demised Premises over leasing any other space in
the building. In any case, the Landlord may make repairs, alterations and
additions in or to the Demised Premises, and redecorate the same to the extent
deemed by the Landlord to be reasonably necessary or desirable, and the Tenant
shall, upon demand, pay the cost thereof, together with the Landlord's expense
of the re-renting. If the consideration collected by the Landlord upon such
re-renting for the Tenant's account is not sufficient to pay monthly the full
amount of the rent reserved in this Lease, together with the cost of repairs,
alterations, additions, redecoration and the Landlord's expenses, the Tenant
shall pay to the Landlord the amount of each monthly deficiency upon demand; and
if the consideration so collected from any such reletting is more than
sufficient to pay the full amount of the rent reserved herein, together with the
costs and expenses of the Landlord, at the end of the stated term of the Lease
Agreement, the Landlord shall refund the surplus to the Tenant.

                  28. REMOVAL OF PROPERTY FROM DEMISED PREMISES
                      -----------------------------------------

                  Any and all property which may be removed from the Demised
Premises by the Landlord pursuant to the authority of this Lease Agreement or of
law, to which the Tenant is or may be entitled, may be handled, removed or
stored by the Landlord at the risk, cost and expense of the Tenant, and the
Landlord shall in no event be responsible for the value, preservation or
safekeeping thereof.

                  The Tenant shall pay to the Landlord, upon demand, any and all
expenses incurred in such removal and all storage charges against such property
so long as the same shall be in the Landlord's possession or under the
Landlord's control. Any such property of the Tenant not removed from the Demised
Premises or re-taken from storage by the Tenant within ten (10) days after the
end of the term, however terminated, shall be presumed to have been conveyed by
the Tenant to the Landlord under this Lease Agreement as a bill of sale without
further payment or credit by the Landlord to the Tenant.

                                       16
<PAGE>   21

                  29. COSTS OF ENFORCEMENT
                      --------------------

                  The Tenant shall pay all the Landlord's cost, charges and
expenses, including the fees of counsel, agents and others retained by the
Landlord, incurred in enforcing the Tenant's obligations hereunder or incurred
by the Landlord in any litigation, negotiations or transactions in which the
Tenant causes the Landlord, without the Landlord's fault, to become involved or
concerned, plus interest at the highest non-usurious rate which Landlord might
at such date have charged in making an unsecured loan of cash funds to Tenant
(but in no event to exceed the rate of eighteen per cent (18%) per annum) from
the date of payment, which amount shall be deemed to be additional rent due and
payable by the Tenant upon demand by Landlord.

                  30. REMEDIES CUMULATIVE
                      -------------------

                  All rights and remedies of the Landlord herein enumerated
shall be cumulative, and none shall exclude any other right or remedy allowed by
law.

                  31. NOTICES
                      -------

                  All bills, statements, notices or communications which
Landlord may desire or be required to give to Tenant shall be deemed
sufficiently given or rendered if in writing and either delivered to Tenant
personally, or sent by registered or certified mail addressed to Tenant at the
Demised Premises, and the time of rendition thereof or the giving of such notice
or communication shall be deemed to be the time when the same is delivered to
Tenant, left at the Demised Premises or deposited in the mail as herein
provided. Any notice by Tenant to Landlord must be served by delivery to
Landlord personally, or sent registered or certified mail addressed to Landlord
at the address where the last previous rent hereunder was payable, or in the
case of subsequent change upon notice given, to the latest address furnished and
shall be deemed to be the time when the same is delivered to Tenant, left at the
Demised Premises or deposited in the mail as herein provided.

                  32. HOLDING OVER, ATTORNMENT, AND LANDLORD'S TITLE
                      ----------------------------------------------

                  (a) Should Tenant continue to occupy the Demised Premises
after the expiration of said term or any renewal or renewals thereof, with the
express or implied consent of Landlord, such tenancy shall be from month to
month and in no event from year to year or for any longer term, and the rent
shall be 150% of the total base rent and additional rent due for the last month
of the lease term.

                  (b) Unless otherwise agreed to in writing by Landlord and
Tenant, if the Tenant retains possession of the Demised Premises or any part
thereof after the termination of the term, the Tenant shall pay the Landlord
rent at twice the monthly rate in effect immediately prior to the termination of
the term for the time the Tenant remains in possession and, in addition thereto,
Tenant shall pay the Landlord for all damages, incidental, consequential, and
direct, sustained by reason of the Tenant's retention of possession. The
provisions of this Paragraph do not exclude the Landlord's rights of re-entry or
any other right or remedy of Landlord hereunder. No such holding over shall be
deemed to constitute a renewal or extension of the term hereof.

                                       17
<PAGE>   22

                  (c) This Lease Agreement and all rights of Tenant hereunder
are subject and subordinate to all ground or underlying leases and to any
mortgage or mortgages, blanket or otherwise, which do or may hereafter affect
the real property of which the Demised Premises form a part and to any and all
renewals, modifications, consolidations, replacements and extensions thereof. It
is the intention of the parties that this provision be self-operative and that
no further instrument shall be required to effect such subordination of this
Lease Agreement. Tenant shall, however, upon demand at any time or times
execute, acknowledge and deliver to Landlord without expense to Landlord, any
and all instruments that may be necessary or proper to subordinate this Lease
Agreement and all rights to Tenant hereunder to any such leases, mortgage or
mortgages or to conform or evidence said subordination. Tenant covenants and
agrees, in the event any proceedings are brought for the foreclosure of any such
mortgage, to attorn to the purchaser, and to recognize such purchaser as the
lessor under this Lease Agreement. Tenant agrees to execute and deliver at any
time and from time to time, upon the request of Landlord or of any holder of
such mortgage or of such purchaser, any instrument which, in the sole judgment
of such requesting party, may be necessary or appropriate in any such
foreclosure proceeding or otherwise to evidence such attornment. Tenant further
waives the provisions of any statute or rule of law, now or hereafter in effect,
which may give or purport to give Tenant any right or election to terminate or
otherwise adversely affect this Lease Agreement and the obligation of Tenant
hereunder in the event any such foreclosure proceeding is brought, prosecuted
and completed. In the event Landlord mortgages the premises, Landlord will use
reasonable efforts to obtain a non-disturbance agreement to protect Tenant.

                  Tenant and Landlord further agree, however, that if so
requested by any Mortgagee that this Lease Agreement be made superior to the
mortgage of said mortgagee, that they will execute such documents as may be
required by such mortgagee to effect the superiority of this Lease Agreement to
such mortgage. Landlord represents that the building is not at this time subject
to any mortgage or other lien or encumbrance.

                  33. CONDEMNATION
                      ------------

                  If the whole or substantially the whole of the Building or of
the Demised Premises shall be lawfully condemned or taken in any manner for any
public or quasi-public use or purpose, this Lease Agreement and the term and
estate hereby granted shall forthwith cease and terminate as of the date of
taking possession for such use or purpose. If less than the whole or
substantially the whole of the Building or of the Demised Premises shall be so
condemned or taken, then Landlord (whether or not the Demised Premises be
affected) may, at its option, terminate this Lease Agreement and the term and
estate hereby granted as of the date of the taking of possession for such use or
purpose by notifying Tenant in writing of such termination. If more than
twenty-five (25%) percent of the Demised Premises taken, Tenant may at its
option terminate this Lease Agreement. Upon any such taking condemnation and the
continuing in force of this Lease Agreement to any part of the Demised Premises,
the Base Rental shall be diminished by an amount representing the part of the
said rent properly applicable to the portion of the Demised Premises which may
be so condemned or taken and Landlord shall, at its expense, proceed with
reasonable diligence to repair, alter and restore the remaining part of the
Building and the Demised Premises to substantially their former condition to the
extent that the same may be feasible. Landlord shall be entitled to receive the
entire award in any condemnation proceeding, including any award to the value of
any unexpired term of this Lease Agreement, and Tenant shall have no claim
against Landlord or against the proceeds of the condemnation except to the
extent expressly provided in the next

                                       18
<PAGE>   23

succeeding sentence and for the cost of all tenant improvements and relocation
expenses. If the temporary use or occupancy of all or any part of the Demised
Premises shall be condemned or taken for any public or quasi-public use during
the term of this Lease Agreement, this Lease Agreement shall be and remain
unaffected by such condemnation or taking and Tenant shall continue to pay in
full the rent, additional rent and other sums payable hereunder by Tenant and
Tenant shall have the right to appear, claim, prove and receive so much of the
award for such taking as represented compensation for use and occupancy of the
Demised Premises up to and including the date of the expiration of the term of
this Lease Agreement or the date of termination of the temporary taking,
whichever is earlier, and Landlord shall be entitled to appear, claim, prove and
receive the entire balance of the award. The terms of this Section shall survive
termination of this Lease.

                  34. FLOOR LOAD, NOISE AND VIBRATIONS
                      --------------------------------

                  Tenant shall not place a load upon any floor of the Demised
Premises which exceeds the load per square foot which such floor was designed to
carry and which is allowed by law. Landlord certifies that the office floors
will carry seventy (70) pounds per square foot live load which includes
allowance for partition load. Landlord reserves the right to prescribe the
weight and position of all safes and heavy installations which Tenant wishes to
place in the Demised Premises so as properly to distribute the weight thereof.

                  Business machines and mechanical equipment belonging to Tenant
which cause vibration, noise, electro-magnetism or other similar phenomena that
may be transmitted to the structure of the Building or any space therein to such
a degree as to be objectionable to Landlord or to any tenants in the Building
shall be placed and maintained by Tenant, at Tenant's expense, on vibration
eliminators or other devices sufficient to eliminate noise or electro-magnetism
and other phenomena which are disruptive of the conduct of business of the
Landlord or other tenants.

                  35. CARE OF PREMISES
                      ----------------

                  Tenant shall, at its own expense, comply with all laws,
orders, ordinances and regulations of Federal, State, County and Municipal
authorities and with any direction made pursuant to law of any public officer or
officers which shall, with respect to the use of the Demised Premises, or to any
abatement of nuisance, impose any violation, order or duty upon Landlord or
Tenant arising from Tenant's use of the Demised Premises or from conditions
which have been created by or at the instance of Tenant or have been created by
a breach of any of Tenant's covenants or agreements hereunder.

                  Tenant shall not do or permit to be done any act or thing upon
the Demised Premises which will invalidate or be in conflict with the terms of
the Ohio standard form of fire, boiler, sprinkler, water damage or other
insurance policies covering the Building and the fixtures and property therein;
and Tenant shall, at its own expense, comply with all rules, regulations, and
requirements of the National Board of Fire Underwriters or any state or other
similar body having jurisdiction, and shall not knowingly do or permit anything
to be done in or upon the Demised Premises in a manner which increases the rate
of fire insurance upon the Building or on any property or equipment located
therein. Nothing herein shall mean that Landlord has any obligation to or will
be responsible for insuring any property of Tenant.

                                       19
<PAGE>   24

                  36. ELECTRICAL REQUIREMENTS
                      -----------------------

                  Landlord, at its expense, shall furnish electric current,
fixture, lamps and equipment for lighting of public lobbies, public corridors,
and other public portions of the Building, and shall furnish electric current
for all air conditioning machinery, elevators and other Building equipment.

                  Tenant shall make no alteration or additions to the electric
equipment, or installments without the prior written consent of Landlord which
consent shall not be unreasonably withheld and work shall be done by Landlord at
Tenant's expense in accordance with plans and specifications of Tenant to be
submitted to and approved by Landlord, which approval shall not be unreasonably
withheld.

                  37. QUIET ENJOYMENT
                      ---------------

                  Landlord covenants that upon Tenant's paying the rent and
additional rent provided for in this Lease Agreement and observing and
performing all the terms, covenants and conditions of this Lease Agreement on
its part to be observed and performed, Tenant may peaceably and quietly enjoy
the Demised Premises, subject, nevertheless, to the terms and conditions of this
Lease Agreement.

                  38. LANDLORD'S RIGHT TO REMEDY DEFAULT
                      ----------------------------------

                  If Tenant shall default in the observance of performance of
any term or covenant on its part to be observed or performed under or by virtue
of any of the terms and provisions in any paragraph of this Lease Agreement,
Landlord, without being under any obligation to do so and without thereby
waiving such default, may remedy such default for the account of and at the
expense of Tenant, immediately and without notice in case of emergency, or in
any other case, only if Tenant shall fail to remedy such default within the
applicable cure period after Landlord shall have notified Tenant in writing of
such default. If Landlord makes any expenditures or incur any obligations for
the payment of money in connection therewith, such sum paid or obligations
incurred with interest and costs shall be paid to it by Tenant.

                  39. LIMITATION ON TENANT'S RIGHT TO TERMINATE
                      -----------------------------------------

                  In the event of any act or omission by Landlord which would
give Tenant the right to terminate this Lease Agreement or to claim a partial or
total eviction, Tenant will not exercise any such right until: (1) it has given
written notice of such act or omission to the Landlord and the holder of any
first mortgage affecting the Building or the Building and the land upon which it
is erected whose name and address shall have been furnished to Tenant in
writing, by delivering such notice of such act or omission addressed to such
holder of such mortgage at the last address so furnished and to the Landlord;
and (2) a reasonable period for remedying such act or omission shall have
elapsed following such giving of notice, provided the Landlord or any such
holder, with reasonable diligence, shall, following the giving of such notice,
have failed to commence and continue to remedy such act or omission or to cause
the same to be remedied.

                                       20
<PAGE>   25

                  40. ESTOPPEL CERTIFICATE
                      --------------------

                  Tenant agrees that when Tenant takes possession of the Demises
Premises and at any other time, and from time to time, upon not less than
fifteen (15) day's prior notice by Landlord, Tenant will execute, acknowledge
and deliver to Landlord, a statement in writing certifying that this Lease
Agreement is unmodified and in full force and effect (or if there have been
modifications, that the same is in full force and effect as modified and stating
the modifications), and the dates to which the rent, additional rent and other
charges have been paid, and stating whether or not to the best knowledge of the
signer of such certificate, Landlord is in default in performance of any
covenant, agreement, term, provision or condition contained in this Lease
Agreement and, if so, specifying each such default of which the signer may have
knowledge, it being intended that any such statement delivered pursuant hereto
may be relied upon by any prospective purchaser or lessee of the Building or of
the Building and the land upon which it is erected, any mortgagee or prospective
mortgagee thereof, or any prospective assignee of any mortgage thereof. Tenant
also agrees to execute and deliver from time to time such estoppel certificates
as an institutional lender may require with respect to this Lease Agreement. The
form of the Estoppel Certificate is attached as Exhibit "40".

                  41. LIABILITY INSURANCE POLICY
                      --------------------------

                  Tenant agrees to carry at its own expense, throughout the term
of this Lease Agreement, public liability insurance covering the Demised
Premises and Tenant's use of the Demised Premises, together with contractual
liability endorsements covering Tenant's obligations under Paragraph 19 of the
Lease Agreement, in companies and in a form satisfactory to Landlord, with
minimums of $1,000,000.00 on account of bodily injuries and/or death of one
person, and $1,000,000.00 on account of bodily injuries and/or death of more
than one person as a result of any one accident or disaster, and with
$1,000,000.00 coverage for property damage in an accident, and whether said
injury or loss occurs in the premises or in or on the common areas, and to
deposit said policy or policies (or certificates thereof) with Landlord prior to
the date of any use or occupancy of the Demised Premises by Tenant, said
policies shall protect Tenant and Landlord, with the Landlord being a named
insured. Should Tenant fail to carry such public liability insurance, Landlord
may at its option (but shall not be required so to do) cause public liability
insurance as aforesaid to be issued, and in such event Tenant agrees to pay the
premium for such insurance promptly upon Landlord's demand. Such liability
insurance policy or policies shall bear endorsements to the effect that the
insurer agrees to notify Landlord not less than ten (10) days in advance of
modification or cancellation thereof.

                  42. CASUALTY INSURANCE
                      ------------------

                  Landlord shall at all times during the term of this Lease
carry, at its own expense, a policy of insurance which insures the Building,
including the Premises, against loss or damage by fire or other casualty
(namely, the perils against which insurance is afforded by the standard fire
insurance policy and extended coverage endorsement); provided, however, that
Landlord shall not be responsible for, and shall not be obligated to insure
against, any loss or damage to any of Tenant's property or any additional
improvements which Tenant may construct on the Premises.

                                       21
<PAGE>   26

                  43. BROKERAGE
                      ---------

                  Except as set forth below, Tenant represents and warrants that
it has dealt with no broker, agent or other person in connection with this
transaction and that no broker, agent or other person brought about this
transaction. Each party agrees to mutually indemnify and hold the other party
harmless from and against any claims by any other broker, agent or other person
claiming a commission or other form of compensation by virtue of having dealt
with Tenant with regard to this leasing transaction. The provisions of this
Paragraph shall survive the termination of this Lease Agreement.

                  Broker/Agent: Landlord's realtor is Adena Realty Advisors.

                  44. MISCELLANEOUS TAXES
                      -------------------

                  Tenant shall pay prior to delinquency all taxes assessed
against or levied upon its occupancy of the Demised Premises, or any taxes
assessed on the rental amounts for the premises by any taxing authority, or upon
the fixtures, furnishing, equipment and all other personal property of Tenant
located in the Demised Premises, if non-payment thereof shall give rise to a
lien on the real estate, and when possible Tenant shall cause said fixtures,
furnishings, equipment and other personal property to be assessed and billed
separately from the real property. In the event any or all of Tenant's fixtures,
furnishings, equipment and other personal property, or upon Tenant's occupancy
of the Demised Premises shall be assessed and taxes with the real property,
Tenant shall pay to Landlord its share of such taxes within ten (10) days after
delivery to Tenant by Landlord of a statement in writing setting forth in the
amount of such taxes applicable to Tenant's fixtures, furnishings, equipment or
personal property.

                  45. CONDITION OF PREMISES
                      ---------------------

                  Except as otherwise agreed in writing, Tenant's taking
possession of the Demised Premises shall be Tenant's acknowledgment and
agreement that the Demised Premises were in good order and satisfactory
condition when the Tenant took possession, except as to latent defects. No
promise of the Landlord to alter, remodel, repair or improve the Demised
Premises or the Building and no representation representing the condition of the
Demised Premises or the Building has been made by Landlord to Tenant, other than
as may be contained herein or in a separate agreement signed by Landlord and
Tenant. At the termination of this Lease Agreement, the Tenant shall return the
Demised Premises "broom-clean" and in as good condition as when the Tenant took
possession, ordinary wear and tear, and loss by fire or other insured casualty
excepted, failing which the Landlord may restore the Demised Premises to such
conditions and the Tenant shall pay the cost thereof on demand.

                  46. TENANT DEFINED
                      --------------

                  The word "Tenant," wherever used in this Lease Agreement,
shall be construed to mean Tenants in all cases where there is more than one
Tenant, and the necessary grammatical changes required to make the provisions
hereof apply to corporations, partnerships or individuals, men or women, shall
in all cases be assumed as though in each case fully expressed.

                                       22
<PAGE>   27

                  47. REPRESENTATIONS OF LANDLORD
                      ---------------------------

                  Neither Landlord nor any of its agents or employees have made
any representations concerning the condition of the Demised Premises, plans for
further development or any other matter relating to this Lease Agreement which
are not contained in this Lease Agreement. Tenant has not relied on any
statements made by Landlord, its employees or agents, not contained herein in
making this Lease Agreement. All prior understandings, terms and conditions are
deemed merged in this Lease Agreement.

                  48. SUBHEADINGS
                      -----------

                  The subheadings of this Lease Agreement are entirely for
purposes of convenience and are in no way determinative of the meaning of the
text of the various paragraphs or parts herein.

                  49. ADDITIONAL TERMS
                      ----------------

                  Any additional terms of this Lease Agreement shall be attached
hereto as Exhibit "49" and signed by the Landlord and Tenant or their authorized
representatives.

                  50. HAZARDOUS SUBSTANCE
                      -------------------

                  (a) Unless Tenant obtains, at its own expense, all
governmental licenses and permits required therefor, Tenant shall not cause or
permit any Hazardous Substance to be used, stored, generated, or disposed of on
or in the Demised Premises by Tenant, Tenant's agents, employees, contractors or
invitees, without first obtaining Landlord's prior written consent, which may be
withheld at Landlord's sole and absolute discretion. Tenant shall, immediately
upon receipt, deliver a copy of all such licenses and permits (together with any
related correspondence) directly to Landlord. If Hazardous Substances are so
used, stored, generated, or disposed of on or in the Demised Premises, or if the
Demised Premises become contaminated by Tenant in any manner for which Tenant is
legally liable, Tenant shall indemnify, defend, protect and hold harmless
Landlord from any and all claims, damages, fines, judgments, penalties, costs,
liabilities, or losses (including, without limitation, a decrease in value of
the Demised Premises, damages because of adverse impact on marketing of the
Demised Premises, and any and all sums paid for settlement of claims,
attorneys', consultants' and experts' fees) arising during or after the term of
this Lease and arising as a result of such contamination by Tenant. This
indemnification includes, without limitation, any and all costs incurred because
of any investigation of the site or any cleanup, removal, or restoration
mandated by a federal, state or local agency or political subdivision. In
addition, if Tenant causes or permits the presence of any Hazardous Substances
on the Demised Premises by Tenant, its agents, employees, contractors or
invitees and this results in contamination, Tenant shall promptly, at its sole
expense, take any and all necessary actions as required by applicable law to
remediate such contamination and shall repair any damage to the Demised Premises
caused by such remediation. The terms and conditions of this Section 50 shall
survive the termination of this Lease.

                  (b) As used herein, "Hazardous Substance" means any substance
which is toxic, ignitable, reactive, or corrosive and which is regulated by any
local government, the State of Ohio, or the United States government. "Hazardous
Substance" includes any and all material or substances which are defined as
"hazardous waste", "extremely hazardous waste", or a "hazardous substance",
pursuant to state, federal or local government law. "Hazardous Substance"
includes but

                                       23
<PAGE>   28

is not restricted to asbestos, polychlorinated biphenyls ("PCBs") and petroleum.

                  51. LAW OF OHIO TO GOVERN
                      ---------------------

                  This Lease Agreement shall be governed by the laws of the
State of Ohio. This Lease Agreement including any orders executed and attached
hereto contains the entire agreement between the parties, and any executory
agreement hereafter made shall be ineffective to charge, modify, discharge or
effect an abandonment of it in whole or in part unless such executory agreement
is in writing and signed by the party against whom enforcement of the change,
modification, discharge or abandonment is sought. If any provision of this Lease
Agreement shall be declared invalid or unenforceable, the remainder of the Lease
Agreement shall continue in full force and effect.

                  52. SHORT FORM LEASE
                      ----------------

                  The parties hereto mutually agree that this Lease Agreement
shall not be recorded, but upon the written request from either one to the
other, a short form of this Lease Agreement in recordable form for filing and
recording in the Office of the Recorder of Franklin County, Ohio which short
form of lease shall be in conformance with Section 5301.251, Ohio Revised Code,
shall be promptly executed, acknowledged and delivered by both parties. Such
short form lease may be recorded by either party.

                                       24
<PAGE>   29

         IN WITNESS WHEREOF, the respective parties hereto have executed this
Lease Agreement or caused this Lease Agreement to be executed by their duly
authorized representatives in three (3) counterparts, each of which counterpart
shall constitute an original Lease Agreement, all said counterparts together
consisting one and the same Lease Agreement as of the day, month and year first
above written.
<TABLE>
<CAPTION>
<S>                                                  <C>
Signed in the presence of:                           LANDLORD:
/s/ Jane  E. Fette
--------------------------------                     PHARMACIA & UPJOHN COMPANY
    Jane  E. Fette                                   successor by merger to Adria
--------------------------------                     Laboratories, Inc.
(Print Name)

/s/ Paula A. Wright Burns                            By: /s/ Theodore P. Pokorski
--------------------------------                        -------------------------------
    Paula A. Wright Burns                                Theodore P. Pokorski
--------------------------------                     Its: Manager, Real Estate
(Print Name)

                                                     TENANT:
Signed in the presence of:
/s/ Nancy B. Young                                   OPTICON MEDICAL, INC.
--------------------------------
    Nancy B. Young
--------------------------------
(Print Name)                                         By: /s/ William Post
                                                        -------------------------------
/s/ Marjorie B. Karhoff                                 William Post
--------------------------------                        Its: President and CEO
    Marjorie B. Karhoff
--------------------------------
(Print Name)
</TABLE>

                                       25
<PAGE>   30

                            LANDLORD'S ACKNOWLEDGMENT
                            -------------------------

STATE OF MICHIGAN          )
                           Section:
COUNTY OF KALAMAZOO        )

                  Before me, a Notary Public in and for said County and State,
personally appeared the above named Pharmacia & Upjohn Company successor by
merger to Adria Laboratories, by Theodore P. Pokorski, its Real Estate Manager,
who acknowledged that he did sign the foregoing instrument, including Exhibits
1, 15, 40 and 49 and that the same is his free act and deed on behalf of the
company.

                  IN TESTIMONY WHEREOF, I have hereunto set my hand and official
seal at Kalamazoo, Michigan, this 27th day of August, 1998.

                                               /s/ Jane E. Fette
                                               -------------------------------
                                               NOTARY PUBLIC
                                               My commission expires: 11/16/2000
                                                                     -----------

<PAGE>   31

                        TENANT CORPORATE ACKNOWLEDGEMENT
                        --------------------------------

STATE OF OHIO            )
                         ) SS:
COUNTY OF FRANKLIN       )

                  On this 20th day of August, 1998, before me appeared William
Post, to me personally known, who being by me duly sworn, did say that he is the
President and C.E.O. of Opticon Medical, Inc., the corporation that executed the
within and foregoing instrument including Exhibits 1, 15, 40 and 49 and that
said instrument was signed and sealed in behalf of said corporation by authority
of its Board of Directors and said William Post acknowledged said instrument to
be the free act and deed of said corporation.

                                        /s/ Nancy B. Young
                                        --------------------------------
                                        NOTARY PUBLIC
                                        My commission expires:
                                                              -----------
<PAGE>   32

                                   EXHIBIT "1"

                                   Floor Plan
                                   ----------
                                  EXHIBIT "14"

                              RULES AND REGULATIONS
                              ---------------------

                  1. Landlord shall have the right to control and operate the
public portions of the Building and the public facilities, as well as facilities
furnished for the common use of the Tenants, in such manner as it deems best for
the benefit of the Tenants generally. No Tenant shall invite to the premises, or
permit the visit of persons in such numbers or under such conditions as to
interfere with the use and enjoyment of the entrances, corridors, elevators and
facilities of the Building by other Tenants.

                  2. Landlord may refuse admission to the Building outside of
ordinary business hours to any person not known to the watchman in charge or
having a pass issued by Tenant or not properly identified, and may require all
persons admitted to or leaving the Building outside of ordinary business hours
to register.

                  3. No awning, advertisements, or other projections over and
around the windows or entrances of the Demised Premises shall be installed by
any Tenant.

                  4. Freight, furniture, business equipment, merchandise and
bulky matter of any description ordinarily shall be delivered to and removed
from the Demised Premises only in the elevators after previous arrangements have
been made with the property manager and through the entrances, stairs and
corridors, but special arrangements will be made for moving large quantities of
furniture and equipment into or out of the Building. Moving furniture or large
equipment into or out of the building must be scheduled with landlord at least
seven (7) days in advance. Landlord reserves the right to set times for regular
deliveries.

                  5. All entrance doors in the Demised Premises shall be left
locked when the premises are not in use.

                  6. Canvassing, soliciting or peddling in the Building is
prohibited and each Tenant shall cooperate to prevent the same.

                  7. Tenant shall not advertise the business, profession, or
activities of Tenant in any manner which violates the letter or spirit of any
code of ethics adopted by any recognized association or organization pertaining
thereto or use the name of the Building for any purpose other than that of the
business address of Tenant.

<PAGE>   33

                  8. Tenant shall not attach or permit to be attached additional
locks or similar devices to any door, transom or window of the Demised Premises;
change existing locks or the mechanism thereof; or make or permit to be made any
keys for any door thereof other than those provided by landlord. (If more than
two keys for one lock are desired Landlord will provide them upon payment
therefor by Tenant.)

                  9. Sidewalks, doorways, vestibules, halls, stairways, and
other similar areas shall not be obstructed by tenants or used by any tenant for
purposes other than ingress and egress to and from their respective leased
premises and for going from one to another part of the Building, except to the
extent necessary during construction of any Tenant improvements or as Tenant may
find temporarily necessary to perform its repair and maintenance obligations as
required by this Lease.

                  10. Plumbing, fixtures and appliances shall be used only for
the purposes for which designed, and no sweepings, rubbish, or rags shall be
thrown or deposited therein. Damage resulting to any such fixtures or appliances
from misuse by a tenant or its agents, employees or invitees, shall be paid by
such tenant.

                  11. Landlord shall provide and maintain an alphabetical
directory for all tenants in the main lobby of the Building.

                  12. To ensure orderly operation of the Building, no ice,
mineral or other water, towels, shall be delivered to any leased area except by
persons approved by Landlord.

                  13. No vending or dispensing machines of any kind may be
maintained in any leased premises without the prior written permission of
Landlord, which permission will not be unreasonably withheld.

                  14. Tenant agrees that it shall not willfully do or omit to do
any act or thing which shall discriminate or segregate upon the basis of race,
color, creed or national origin in the use and occupancy or in any subleasing or
subletting of the Demised Premises.

                  15. Landlord reserves the right by written notice to
terminate, rescind, alter or waive any rule or regulation at any time prescribed
for the Building or make additional rules and regulations when, in the
reasonable exercise of Landlord's judgment, it is necessary, desirable or proper
for the best interest of the Building and its Tenants.

<PAGE>   34

                                  EXHIBIT "40"

                                 TENANT ESTOPPEL
                                 ---------------
                                   CERTIFICATE
                                   -----------

TO:  __________________________
DATE:  _______________________

RE:

                  Lease    Commencement     Date:  ____________________
                  Between:

                  and, _______________________________, Tenant

                  Rentable Area Leased:  _______________________
                  Suite No.:  _____________________________
                  Floor:  __________________________

         The undersigned, Tenant under the above-referenced lease ("Lease"),
certifies to
_______________________________________________________________________________,
the following:

                  1. The above-described Lease has not been canceled, modified,
assigned, extended or amended except as follows:________________________________

                  2. There is no prepaid rent except $___________ and the amount
of security deposit is _____________ $___________________.

                  3. We took possession of the Premises on _____________ and
commenced (or will commence) to pay Rent on _______________ in the amount of
$________________. Rent was last paid on ________________, ______, and has been
paid through _______________.

                  4. The Lease terminates on _____________ and we have the
following renewal option(s) ________________________________.

                  5. All work to be performed for us under the Lease has been
performed as required and has been accepted by us, except _____________________.

                  6. The Lease is: (a) in full force and effect; (b) free from
default; and (c) we have no claims against the Landlord or offsets against Rent.

                  7. Except as specifically set forth in said lease the
undersigned has received no Rental inducements, free rent or any other
inducement to enter into the lease except as follows:
__________________________________________________________________________

<PAGE>   35

                  8. The undersigned has received no notice of prior sale,
transfer or assignment, hypothecation or pledge of the Lease or of the Rent
secured therein other than to you, except,
__________________________________________________________________________

                  9. That the Premises as let are being used for the purpose as
described in the Lease.

                  10. The undersigned is not the subject of any bankruptcy
reorganization or insolvency proceedings.

                  11. The undersigned acknowledges that:

                           (i) Landlord's interest in the property can be
assigned without affect to the Lease.

                           (ii) Landlord, you and your successors, agents and
assigns (including but not limited to subsequent purchasers, lenders and title
insurers) will be relying upon each of the statement contained herein.

                           (iii) That in the event of an assignment the
undersigned will attorn to and recognize the building's owners as Landlord after
receipt of a formal notice and will pay Rents and other amounts due under the
existing Lease term.

                  If we are a corporation, the undersigned is a duly appointed
officer of the corporation signing this certificate and is the incumbent in the
office indicated under (his)(her) name.

                  In any event, the undersigned individual(s) (is) (are) duly
authorized to execute this certificate.

                  Dated this _________ day of _______________, _________

Witnesseth:                         TENANT:

-------------------------           -------------------------

<PAGE>   36

STATE OF OHIO
COUNTY OF FRANKLIN, SS:

                  BEFORE ME, a Notary Public in and for said County and State,
personally appeared the above named _______________________ who acknowledged
before me that the foregoing instrument was signed for the purposes therein
stated and as the free act and deed of the signer thereof.

                  IN WITNESS WHEREOF, I hereby certify the acknowledgment and
have hereunto subscribed my name and affixed my official seal this ______ day of
_______________, ______.

                                          --------------------------------
                                          Notary Public

<PAGE>   37

                                  EXHIBIT "49"

                             ADDITIONAL LEASE TERMS
                             ----------------------

                           [INTENTIONALLY LEFT BLANK]<PAGE>   1
                                                                    EXHIBIT 10.2

                   FIRST AMENDMENT TO LEASE AGREEMENT BETWEEN
                    PHARMACIA & UPJOHN COMPANY, SUCCESSOR BY
                 MERGER TO ADRIA LABORATORIES, INC., "LANDLORD",
                       AND OPTICON MEDICAL, INC., "TENANT"
                    SAID LEASE DATED AS OF OCTOBER 27, 1998

                  The parties hereto, Pharmacia & Upjohn Company, successor by
merger to Adria Laboratories, Inc., a Delaware corporation ("Landlord"), and
Opticon Medical, Inc., an Iowa corporation (hereinafter referred to as "Tenant")
as of this 27th day of October, 1998 hereby agree to the First Amendment of the
captioned lease in the following respects:

                  1. Premises. The usable square footage is 4,028, and the
Rentable Square Footage is 4,270.

                  2. Term. The term of the Lease Agreement commenced on the 15th
day of September, 1998 and will expire on the 30th day of September, 2001.

                  3. Rent. The Rent Commencement Date is October 1, 1998
continuing through September 30, 2001. Therefore the rent is:
<TABLE>
<CAPTION>

================================================================================================
YEAR                                      ANNUAL NET RENT PER      NET RENT        NET RENT PER
                                          SQ. FT.                  PER YEAR        MONTH
------------------------------------------------------------------------------------------------
<S>                                      <C>                      <C>             <C>
October 1, 1998 - September 30, 1999      $7.80                    $33,306.00      $2,775.50
------------------------------------------------------------------------------------------------
October 1, 1999 -September 30, 2000       $8.00                    $34,160.00      $2,846.67
------------------------------------------------------------------------------------------------
October 1, 2000 - September 30, 2001      $8.20                    $35,014.00      $2,917.83
================================================================================================
</TABLE>

together with estimated annual Operating Expenses (defined herein) of $5.95 per
square foot (currently, the estimated $5.95 times 4,270 = $25,406.50 annually,
or $2,117.21 monthly), in advance, in equal monthly installments (initially
$4,892.71) on the first day of each calendar month beginning October 1, 1998,
without any setoff or counterclaim whatsoever. These amounts shall hereinafter
be called "Base Rent."

                  4. Every other provision of the Lease Agreement not
specifically changed in this First Amendment is hereby reaffirmed in all
respects by both parties.

                  IN WITNESS WHEREOF, the respective parties hereto have
executed this First Amendment to Lease Agreement or caused this First Amendment
to Lease Agreement to be executed by their duly authorized representatives in
three (3) counterparts, each of which counterpart shall constitute an original
First Amendment to Lease Agreement, all said counterparts together consisting
one and the same First Amendment to Lease Agreement as of the day, month and
year first above written.

<PAGE>   2
Signed in the presence of:                  LANDLORD:

    /s/ Jane E. Fette
----------------------------                PHARMACIA & UPJOHN COMPANY
    Jane E. Fette                           successor by merger to Adria
----------------------------                Laboratories, Inc.
(Print Name)

                                            By: /s/ Theodore P. Pokorski
    /s/ Paula Wright Burns                     -------------------------------
----------------------------                     Theodore P. Pokorski
    Paula Wright Burns                      Its: Manager, Real Estate
----------------------------
(Print Name)

                                            TENANT:
Signed in the presence of:
                                            OPTICON MEDICAL, INC.
    /s/ Kimberly A. Nice
----------------------------
    Kimberly A. Nice
----------------------------
(Print Name)                                By: /s/ William Post
                                               -------------------------------
/s/ Richard F. Underman                          William Post
----------------------------                Its: President and CEO
Richard F Underman
----------------------------
(Print Name)

                            LANDLORD'S ACKNOWLEDGMENT
                            -------------------------

STATE OF MICHIGAN   )
                        Section:
COUNTY OF KALAMAZOO )

                  Before me, a Notary Public in and for said County and State,
personally appeared the above named Pharmacia & Upjohn Company successor by
merger to Adria Laboratories, by Theodore P. Pokorski, its Real Estate Manager,
who acknowledged that he did sign the foregoing instrument, and that the same is
his free act and deed on behalf of the company.

                  IN TESTIMONY WHEREOF, I have hereunto set my hand and official
seal at Kalamazoo, Michigan, this 23rd day of November, 1998.

                           NOTARY PUBLIC /s/ Jane E. Fette
                                         -----------------------
                           My commission expires: 11/16/2000
                                                  --------------
<PAGE>   3

                        TENANT CORPORATE ACKNOWLEDGEMENT
                        --------------------------------

STATE OF OHIO      )
                     ss:
COUNTY OF FRANKLIN )

                  Before me, a Notary Public in and for said County and State,
personally appeared the above named Opticon Medical, Inc., by William Post,
President and C.E.O., who acknowledged that he did sign the foregoing
instrument, and that the same is his free act and deed on behalf of the
corporation.

                  IN TESTIMONY WHEREOF, I have hereunto set my hand and official
seal at Columbus, Ohio, this 6th day of November, 1998.

                             NOTARY PUBLIC /s/ Richard F. Underman
                                           -------------------------
                             My commission expires: 1-23-2000
                                                    ----------------

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00006-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00006-of-00352.parquet"}]]