Document:

Exhibit 10.42  

EMPLOYMENT AGREEMENT  

        AGREEMENT, made and entered into as of the 8th day of August, 2007, by and between ImClone Systems Incorporated, a Delaware corporation (the "Company"), and
John H. Johnson (the "Executive"). 

W I T N E S S E T H  

        WHEREAS, the Company desires to employ the Executive as its Chief Executive Officer, and the Executive desires to accept such employment; and 

        WHEREAS,
the Company and the Executive desire to enter into this employment agreement (the "Agreement") embodying the terms of such employment; 

        NOW,
THEREFORE, in consideration of the promises and mutual covenants contained herein and for other good and valuable consideration, the receipt of which is mutually acknowledged, the
Company and the Executive (individually a "Party" and together the "Parties") agree as follows: 

        1.    Definitions.    

        (a)   "Base
Salary" shall mean the Executive's base salary as determined in accordance with Section 4 below. 

        (b)   "Board"
shall mean the board of directors of the Company. 

        (c)   "Cause"
shall mean: 

        (1)   an
indictment for, or a conviction of the Executive for, or a plea of nolo contendere to, a felony, any crime under the
federal or state securities laws or regulations, or a misdemeanor involving moral turpitude; or 

        (2)   willful
misconduct or gross negligence by the Executive in the performance of his duties hereunder; or 

        (3)   a
willful failure by the Executive to attempt in good faith to perform his duties hereunder, or a willful failure by the Executive to attempt in good faith to carry out
the legal directions of the Board promptly and continuously, in either case after written notice of such failure; or 

        (4)   fraud,
embezzlement, theft or dishonesty by the Executive against the Company or any Subsidiary; or 

        (5)   or
any act of willful misconduct by the Executive bringing harm, or in the good faith judgment of the Board, likely to bring harm to the Company or any Subsidiary
(economically or as to reputation); or 

        (6)   a
violation by the Executive of a written policy or procedure of the Company or any Subsidiary of a material nature, as determined in the good faith judgment of the
Board; or 

        (7)   a
mispresentation by the Executive of his credentials or experience; or 

        (8)   a
material breach by the Executive of any provision of this Agreement, including a failure to purchase or maintain the equity ownership holdings in accordance with
Section 7 of this Agreement, that is not cured (if capable of being cured) within 10 days of Executive's being given written notice from the Company specifying such breach. 

        (d)   "Change
of Control" shall mean when any "person" (as defined in Section 13(d) and 14(d) of the Securities Exchange Act of 1934) (other than (i) any
shareholder who, as of the date hereof, has a Schedule 13D on file with the Securities and Exchange Commission, (ii) any trustee or other fiduciary holding securities under an employee
benefit plan of the Company or any Subsidiary, or (iii) any corporation owned, directly or indirectly, by the stockholders of the Company, in substantially the same 

 

proportions
as their ownership of stock of the Company), acquires, in a single transaction or a series of transactions (whether by merger, consolidation, reorganization or otherwise), "beneficial
ownership" (as defined in Rule 13d-3 under the Securities Exchange Act of 1934) of securities representing 100% of voting power of the Company 

        (e)   "Code"
shall mean the Internal Revenue Code of 1986, as amended from time to time. 

        (f)    "Competitive
Activity" shall mean the Executive's engaging in an activity—whether as an employee, consultant, principal, member, agent, officer, director,
partner, sole proprietor, or shareholder (except as a less than 1% shareholder of a publicly traded company)—that is competitive with any product marketed and sold by the Company or any
Subsidiary, or which would compete with any product proposed to be developed or marketed and sold by the Company or any Subsidiary and as to which the Company or any Subsidiary has devoted significant
efforts, provided that such measurement shall be made at the earlier of the activity of Executive, and termination hereunder; and provided,
further, that after the Executive's termination hereunder, the Executive shall not be deemed to be engaging in a Competitive Activity if he provides services to a
subsidiary, division or affiliate of an entity engaged in a Competitive Activity (a) if such subsidiary, division or affiliate is not itself engaged in a Competitive Activity and not involved
with therapeutic antibodies, (b) the portions of the entity engaged in Competitive Activity and/or therapeutic antibodies comprise no more than 10% of the revenues of the business enterprise as
a whole in the fiscal year of the entity ending immediately prior to the activity by the Executive, and (c) the Executive does not directly or indirectly provide services to, supervise or
manage the employees of, or have any responsibilities regarding, the Competitive Activity or the therapeutic antibody area. 

        (g)   "Disability"
shall mean the Executive's inability, due to physical or mental incapacity, to substantially perform his duties and responsibilities under this Agreement
for a period of (i) 6 consecutive months or (ii)180 days in any 12-month period, as determined by the Board. 

        (h)   "Effective
Date" shall mean August 27, 2007. 

        (i)    "Good
Reason" shall mean, without the Executive's prior written consent, the occurrence of any of the following events or actions within the 30-day period
preceding a notice of termination of employment delivered to the Company by the Executive: 

        (1)   a
reduction of the Executive's Base Salary or Target Bonus as a percentage of Base Salary, except due to an across the board reduction applicable to similarly situated
senior-level executives generally; 

        (2)   the
failure to be elected or reelected the Chief Executive Officer of the Company and its Subsidiaries; 

        (3)   a
material breach by the Company of this Agreement; 

        (4)   a
material diminution in the Executive's titles, authority, duties or responsibilities, including but not limited to as a result of a change in the Company's
by-laws that is not legally required; 

        (5)   a
change in the reporting structure so that the Executive reports to someone other than solely to the Board and the Chairman of the Board; 

        (j)    "Subsidiary"
shall mean a corporation of which the Company owns more than 50% of the voting stock or any other business entity in which the Company directly or
indirectly has an ownership interest of more than 50%. 

        (k)   "Term
of Employment" shall mean the period specified in Section 2 below. 

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        2.    Term of Employment.    

        The
Company hereby employs the Executive, and the Executive hereby accepts such employment, for the period commencing on the Effective Date and ending on the fourth anniversary of the
Effective Date, subject to earlier termination of the Term of Employment in accordance with the terms of this Agreement. The parties may, but shall not be obligated to, extend the Term of Employment
by written
agreement. If not so extended by written agreement, any employment after the fourth anniversary shall be employment at will. 

        3.    Position, Duties and Responsibilities; Reporting.    

        (a)   As
of the Effective Date, the Executive shall be employed as the Chief Executive Officer of the Company and its Subsidiaries and shall be responsible for the general
management of the affairs of the Company and its Subsidiaries as provided in the Company's by-laws. The Executive shall serve the Company and its Subsidiaries faithfully, conscientiously
and to the best of the Executive's ability and shall promote the interests and reputation of the Company and its Subsidiaries. The Executive shall devote substantially all of the Executive's working
time, attention, knowledge, energy and skills to the duties of the Executive's employment. The Executive, in carrying out his duties under this Agreement, shall report solely to the Board and the
Chairman of the Board, and shall carry out the legal directives of the Board in good faith. With the prior written approval of the Board (which may be withheld or withdrawn at any time), the Executive
may (i) serve on the boards of directors of other corporations, (ii) serve on the boards of trade associations and/or charitable organizations, and (iii) engage in charitable
activities and community affairs. Additionally, the Executive may manage his passive personal investments, provided that such activities (including those in the prior sentence) do not materially
interfere and are not inconsistent with the effective discharge of his duties and responsibilities to the Company and its Subsidiaries. 

        (b)   It
is the intention of the Parties that the Executive shall serve as a member of the Board at all times during the Term of Employment and the Company shall propose his
nomination and renomination as such during the Term of Employment, except as such is in conflict with applicable law or regulations to which the Company is subject. 

        4.    Base Salary    

        During
the Term of Employment, the Executive shall be paid an annualized Base Salary of $600,000, payable in accordance with the regular payroll practices of the Company. The Base Salary
is subject to increase in the sole discretion of the Board. 

        5.    Annual Incentive Compensation Programs and Sign on Bonus.    

        (a)   During
the Term of Employment, the Executive shall participate in the Company's annual incentive compensation plan applicable to senior-level executives as established
and modified (in respect of senior-level executives generally) from time to time by the Board in its sole discretion. The Executive shall have an annual incentive compensation opportunity under such
plan with an annual cash target award of 100% of Base Salary (the "Target Bonus"). Payment of annual incentive compensation awards shall be made at the same time that other senior-level executives
receive their annual incentive compensation awards in the calendar year following the year earned. 

        (b)   The
Company shall pay the Executive a sign on bonus of $100,000 in cash within thirty (30) days after the Effective Date. In the event the Executive voluntarily
resigns without Good Reason or is terminated for Cause within one (1) year of the Effective Date, he shall promptly refund such sign-on bonus. 

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        6.    Long-Term Incentive Compensation Grants.    

        (a)   The
Executive shall receive on the Effective Date a grant of $1,000,000 in restricted stock units in respect of the Company's common stock (the "RSU's") pursuant to the
Company's 2006 Stock Incentive Plan (the "Plan"), valued at the closing price of the Company's common stock on the Effective Date. The RSU's will vest 25% on each of the first four anniversaries of
the Effective Date, subject to the Executive's continuous employment, except that the RSU's shall immediately vest in full upon the earlier to occur of (i) a Change in Control and (ii) a
termination of the Executive's employment hereunder without Cause, or for Good Reason. The RSU's which are vested at the time of Executive's separation from service will be settled and paid subject to
Section 23 below promptly after the Executive's separation from service for any reason. Other terms and conditions relating to the RSU's shall be contained in an award agreement between the
Company and the Executive in the Company's standard form, as modified to include the provisions of this Section 6(a). 

        (b)   The
Executive shall receive on the Effective Date a grant of an option to purchase 350,000 shares of the Company's common stock (the "Option") pursuant to the Plan. The
exercise price of the Option will be the closing price of the Company's common stock on the Effective Date. The Option will vest 25% on each of the first four anniversaries of the Effective Date,
subject to the Executive's continuous employment, except that the Option shall immediately vest in full upon the earlier to occur of (i) a Change in Control and (ii) a termination of the
Executive's employment without Cause or for Good Reason. The Option shall expire on the 10th anniversary of the date of grant, or sooner if there is a termination of the Executive's employment and, in
such case, as provided under the Plan and grant. Other terms and conditions relating to the Option shall be contained in an award agreement between the Company and the Executive in the Company's
standard form, as modified to include the provisions of this Section 6(b). 

        (c)   During
the Employment Term, the Executive shall be eligible to participate in the Company's applicable long-term incentive compensation plan(s) on the same
basis as generally available to other senior-level executives, as may be established and modified (in respect of senior-level executives generally) from time to time by the Board in its sole
discretion. 

        7.    Equity Purchase.    

        Executive
hereby agrees that, subject to compliance with applicable Federal and State securities laws, applicable Company policies and the rules of the stock exchange on which the
Company's common stock is listed, including but not limited to insider trading rules (each, a "Restriction"), during the period beginning as of the date which is three (3) business days
following the public announcement of the Executive's employment with the Company and ending ninety (90) days after the Effective Date, Executive shall purchase shares of common stock of the
Company in the market or from the Company, as the parties mutually agree, with a market value (at the time of purchase) of $500,000, it being agreed that such ninety (90) day period shall be
extended for the period of time the Executive is prevented from purchasing such shares as a result of any of the Restrictions if the Executive is unable to purchase the shares in the market and the
Company is unable or unwilling to issue and sell the shares to the Executive or the Executive is prevented by the Restrictions from buying the shares from the Company. Executive shall hold such number
of shares so purchased during the Term of Employment and for a period of at least one year thereafter; provided the requirement to hold such shares
shall terminate on the earlier to occur of a termination of the Executive's employment without Cause, for Good Reason, or upon a death or a Disability termination. In addition, such obligation shall
terminate on a corporate transaction where shares of the Company are exchanged for cash. Such shares acquired by the Executive pursuant to this Section 7 shall be legended with the restrictions
and their termination as set forth herein, and the Company's books shall reflect such restrictions and their termination. 

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        8.    Employee Benefit Programs.    

        (a)   During
the Term of Employment, the Executive shall be entitled to participate in all employee welfare and pension benefit plans, programs and/or arrangements applicable
to the Company's senior-level executives generally upon the terms and conditions, as modified from time to time, of such plans, programs and arrangements. The Executive shall be entitled to
participate in the Company's vacation and other time off programs in accordance with the terms thereof in effect from time to time (including but not limited to those as to carry forward of, or
payment for, unused vacation), provided that his annual accrual and entitlement to vacation days over each year of vacation measurement (prorated for partial years) shall be at least four weeks. 

        (b)   Notwithstanding
anything elsewhere to the contrary, the Executive shall not be eligible to participate in the Company's Change-in-Control Plan,
the Senior Executive Severance Plan, or any other severance plan, except as specifically agreed to by the Company; it being intended that the severance provisions herein are intended to be in lieu of
benefits under any other severance program. 

        9.    Reimbursement of Business Expenses.    

        The
Company shall reimburse the Executive for all reasonable business expenses reasonably incurred during the Employment Term in connection with carrying out the business of the Company
in accordance with the Company's policy, subject to such documentation as the Company's policy may require and such reimbursement shall occur no later than June 30 of the calendar year
following the calendar year in which they were incurred. 

        10.    Termination of Employment.    

        (a)    Termination of Employment Due to Death.    In the event of the Executive's death during the Term of Employment,
the Term of Employment shall end as of the date of the Executive's death and his estate and/or beneficiaries, as the case may be, shall be entitled to the following: 

        (1)   Base
Salary earned but not paid through the date of termination, payable within 15 days of the date of termination; 

        (2)   any
incentive compensation earned for a fiscal year ending prior to the date of termination, payable when such compensation is otherwise paid to other senior executives
generally in the calendar year of termination; and 

        (3)   any
amounts earned, accrued or owing to the Executive but not yet paid under Sections 8 and 9 (and the plans, programs or policies referred to therein), payable at the
time set forth in the relevant plan, program or policy (together with (1) and (2), the "Accrued Obligations"). 

        (b)    Termination of Employment Due to Disability.    The Company may terminate the Executive's employment due to
Disability by written notice pursuant to Section 25 hereof. In such event, the Term of Employment shall end as of the date of the termination of the Executive's employment specified in such
notice, and the Executive shall be entitled to the Accrued Obligations. 

        (c)    Termination of Employment by the Company for Cause.    If the Company terminates the Executive's employment for
Cause during the Term of Employment, the Term of Employment shall end as of the date of the termination of the Executive's employment for Cause and the Executive shall be entitled to the amounts set
forth in clauses (1) and (3) of Section 10(a) above. Notwithstanding anything elsewhere to the contrary, if the Company becomes aware of facts or circumstances which occurred or
existed during the Term of Employment and which constituted "Cause," the Executive shall only be entitled to the amounts set forth in clauses (1) and (3), and the Executive shall have an
obligation to repay any excess amounts (including without limitation the value of equity that would not have vested) otherwise received. 

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        (d)    Termination of Employment by the Company Without Cause.    If the Executive's employment is terminated by the
Company without Cause, other than due to death or Disability, the Term of Employment shall end as of the date of such termination and the Executive shall be entitled to the following, subject to
Sections 10(g) and 10(k) and compliance with the Executive's obligations pursuant to Sections 11, 12(a) & (b), and 13: 

        (1)   the
Accrued Obligations; 

        (2)   a
pro rata annual cash bonus award for the year of termination, based on actual results, payable in the following calendar year at the time bonuses are paid to similarly
situated senior-level executives generally; 

        (3)   his
annual Base Salary, at the rate in effect on the date of termination (without giving effect to any decrease in such rate which has given rise to Good Reason),
payable in installments for a period of 12 months, commencing (subject to the provisos below) on the first regular payroll date after the date of termination in accordance with the Company's
regular payroll practices applicable to payment of salaries, provided that no amounts shall be due prior to the effective date of the release described in Section 10(k) and the first
installment thereafter shall include all payments that would otherwise have been made prior to the effective date of the release; and provided further that payments pursuant to this section shall be
subject to delay in accordance with Section 23(b) hereof; 

        (4)   full
and immediate vesting of the Option, which shall remain exercisable for ninety days after the date of termination; 

        (5)   full
and immediate vesting of the RSU's, and settlement of the RSU's in accordance with the terms of the applicable award agreement which will be consistent with
Section 6(a) hereof; 

        (6)   provided
he timely elects COBRA health continuation coverage and timely pays the amount payable by similarly situated active senior-level employees, the Company shall
continue to provide medical coverage for Executive and his eligible dependents until the earliest of (x) one (1) year from his termination, (y) his (or the eligible dependent)
ceasing to be eligible for COBRA coverage) or (z) he commences employment with an employer who maintains a medical plan. 

The
Company shall give written notice to the Executive of any termination without Cause in accordance with Section 25 below. 

        (e)    Termination of Employment by the Executive for Good Reason.    The Executive may terminate his employment for
Good Reason, provided that the actual date of the termination of the Executive's employment occurs during the 75-day period immediately following the date that the events or actions
constituting Good Reason first become known to the Executive. Upon a termination by the Executive of his employment for Good Reason, the Term of Employment shall end as of the date of such termination
and the Executive shall be entitled to the same payments and benefits as provided in Section 10(d) above. In no event shall a termination of the Executive's employment for Good Reason occur
unless the Executive gives written notice to the Company in accordance with Section 25 below stating with reasonable specificity the events or actions that constitute Good Reason within
45 days of their occurrence and providing the Company with an opportunity to cure (if curable) within 30 days. 

        (f)    Voluntary Termination of Employment by the Executive Without Good Reason.    The Executive may voluntarily
terminate his employment without Good Reason, other than a termination of employment due to death or Disability, in which case the Term of Employment shall end as of the date of such termination and
the Executive shall be entitled to the amounts set forth in clauses (1) and (3) of Section 10(a) above. In no event shall a voluntary termination of the Executive's employment
without Good Reason occur unless the Executive gives written notice to the Company in accordance with Section 25 below at least 90 days prior to the date of the actual date of the
termination of the Executive's employment; provided, however, that the Company may shorten such period in its sole discretion. 

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        (g)    No Mitigation; Offset.    In the event of termination of his employment, the Executive shall be under no
obligation to seek other employment and there shall be no offset against amounts due to him on account of any remuneration or benefits provided by any subsequent employment he may obtain. The
Company's obligation to make any payment pursuant to, and otherwise to perform its obligations under, this Agreement shall be subject to setoff, counterclaim and the Company's other rights with
respect to any claim the Company may have against the Executive for any reason. 

        (h)    Return of Company Property.    On or immediately following the date of any termination of the Executive's
employment, the Executive or his personal representative shall return all property of the Company and Subsidiaries in his possession, including but not limited to all computer equipment (hardware and
software), telephones, facsimile machines, palm pilots and other communication devices, credit cards, office keys, security access cards, badges, identification cards and all copies (including drafts)
of any documentation or information (however stored) relating to the business of the Company and its Subsidiaries, its customers and clients or its prospective customers and clients. Anything to the
contrary notwithstanding, the Executive shall be entitled to retain (i) personal papers and other materials of a personal nature, provided that such papers or materials are not related to the
business and do not include confidential information, including, but not limited to, photographs, correspondence, personal diaries, calendars and rolodexes, personal files and phone books, provided
that such papers or materials are not related to the business and do not include confidential information, and provided further that only copies of personal diaries, calendars and rolodexes may be
taken and the originals shall be left with the Company, (ii) information showing his compensation or relating to reimbursement of expenses, and (iii) copies of plans, programs and
agreements relating to his employment, or termination thereof, with the Company which he received in his capacity as a participant. 

        (i)    Resignation as an Officer and Director.    On or immediately following the date of any termination of the
Executive's employment, and as a condition of receiving severance hereunder, the Executive shall submit to the Company in writing his resignation as (i) an officer of the Company and of all
Subsidiaries and (ii) a member of the Board and of the board of directors of all Subsidiaries. 

        (j)    Nature of Payments.    Any amounts due under this Section 10 are in the nature of severance payments
considered to be reasonable by the Company and are not in the nature of a penalty. 

        (k)    Waiver and Release.    As a condition precedent to receiving the compensation and benefits provided under
Sections 10(d) or 10(e), as applicable, the Executive shall execute a waiver and release substantially in the form attached to this Agreement as Schedule A. Such release shall be executed by
the Executive and delivered to the Company within thirty (30) days of the date of the applicable date of termination. 

        (l)    Cooperation.    During and following the Term of Employment, the Executive shall give his assistance and
cooperation willingly, upon reasonable advance notice, in any matter relating to his position with the Company and its Subsidiaries, or his knowledge as a result thereof as the Company may reasonably
request, including his attendance and truthful testimony where deemed appropriate by the Company, with respect to any investigation or the Company's (or a Subsidiary's) defense or prosecution of any
existing or future claims or litigations or other proceeding relating to matters in which he was involved or had knowledge by virtue of his employment with the Company. In any event, any request of
such cooperation following the Term of Employment shall take into account the Executive's other personal and business commitments to the extent reasonably feasible. The Company will reimburse the
Executive for reasonable travel costs and expenses incurred by him (in accordance with Company policy) as a result of providing such assistance, upon the submission of the appropriate documentation to
the Company. Additionally, the Executive agrees to promptly inform the Company if the Executive becomes aware of any claims or litigations involving the Company or any Subsidiary that may be filed or
threatened against the Company or any Subsidiary. The Executive also agrees to 

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promptly
inform the Company (to the extent the Executive is legally permitted to do so) if the Executive becomes aware of or is asked to assist in any investigation of the Company or any Subsidiary or
any of their actions, regardless of whether a lawsuit or other proceeding has then been filed with respect to such investigation, and shall not so assist unless legally required to do so, or as
otherwise otherwise authorized by the Company in writing. In the event the Executive is required following his termination of employment with the Company to assist the Company pursuant to this
Section 10 for more than 10 days in any calendar year, the Company shall pay to the Executive a per diem for each day of assistance thereafter during such calendar year at a rate based
on his Base Salary at the time of his termination of employment divided by 260, payable in a cash lump sum within 45 days following such assistance; provided, however that (i) assistance
will be permitted to be given from the Executive's home or normal place of business in the Company's sole discretion, and (ii) such assistance, or days involving actual testimony, shall not be
included for any purpose of this sentence. 

        11.    Confidentiality: Assignment of Rights.    

        (a)   During
the Term of Employment and thereafter, the Executive shall not disclose to anyone or make use of any trade secret or proprietary or confidential information of
the Company or any Subsidiary, including such trade secret or proprietary or confidential information of any customer or other entity to which the Company or any Subsidiary owes an obligation not to
disclose such information, which he acquires during the Term of Employment, including but not limited to records kept in the ordinary course of business, except (i) as such disclosure or use
may be required or appropriate in connection with his work as an employee of the Company or in connection with his cooperation pursuant to Section 10(l) above, (ii) when required to do
so by a court of law, by any governmental agency having supervisory authority over the business of the Company or any Subsidiary or by any administrative or legislative body (including a committee
thereof) with apparent jurisdiction to order him to divulge, disclose or make accessible such information, (provided that the Executive provides the Company with prior notice of the contemplated
disclosure and reasonably cooperates with the Company in seeking a protective order or other appropriate protection of such information), and (iii) as to such confidential information that
becomes generally known to the public or trade without his violation of this Section 11(a). 

        (b)   The
Executive hereby sells, assigns and transfers to the Company all of his right, title and interest in and to all inventions, discoveries, and improvements, whether or
not copyrightable or patentable (the "rights") which during the Term of Employment are made or conceived by him, alone or with others, and which are within or arise out of the Company's or any
Subsidiary's business or arise out of any work he performs or information he receives regarding the business of the Company while employed by the Company. The Executive shall fully disclose to the
Company as promptly as available all information known or possessed by him concerning the rights referred to in the preceding sentence, and upon request by the Company and without any further
compensation in any form to him by the Company, but at the expense of the Company, execute all applications for patents and for copyright registration, assignments thereof and other instruments and do
all things which the Company may deem reasonably necessary to vest and maintain in it the entire right, title and interest in and to all such rights. 

        12.    Noncompetition; Nonsolicitation.    

        (a)   The
Executive covenants and agrees that during the period commencing on the Effective Date and ending on the first anniversary of the date of the termination of the
Executive's employment, he shall not at any time, without the prior written consent of the Company, directly or indirectly, engage in a Competitive Activity. 

        (b)   The
Executive covenants and agrees that during the period commencing on the Effective Date and ending in the case of (x) below, on the first anniversary of the
date of the termination of the Executive's employment, and in the case of (y) below, on the second anniversary of the date of such 

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termination,
he shall not at any time, directly or indirectly, (x) solicit any customer or client of the Company or any Subsidiary with respect to a
Competitive Activity or assist any person in doing so, or interfere with the Company's relationship with any customer, client or vendor, or (y) solicit
or hire, or assist any person in soliciting or hiring, any employee of the Company or any Subsidiary (or any person who had been an employee of the Company or any Subsidiary within the prior
six-month period). Anything to the contrary notwithstanding, the Company agrees that the following shall not be deemed a violation of this Section 12(b) the Executive's responding
to an unsolicited request for an employment reference regarding any former employee of the Company or any Subsidiary from such former employee, or from a third party, by providing a reference setting
forth his personal views about such former employee. For purposes hereof, the Executive shall only be deemed to have been involved "indirectly" in soliciting, hiring or identifying an employee if the
Executive (x) directs a third party to solicit or hire the Employee, (y) identifies an employee to a third party as a potential recruit or (z) aids, assists or participates with a
third party in soliciting or hiring an employee, or approves such hiring. 

        (c)   The
Parties acknowledge that in the event of a breach or threatened breach of Sections 11, 12(a) and/or Section 12(b) above, or Section 13 below, the
Company shall not have an adequate remedy at law. Accordingly, and notwithstanding anything contained in this Agreement to the contrary, in the event of any breach or threatened breach of Sections 11,
Section 12(a) and/or Section 12(b) above, or Section 13 below, the Company shall be entitled to such equitable and injunctive relief as may be available to restrain the Executive
from the violation of the provisions of Section 11, Section 12(a) and/or Section 12(b) above, or Section 13 below. Nothing in this Agreement shall be construed as
prohibiting the Company from pursuing any other remedies available at law or in equity for breach or threatened breach of Section 11, Section 12(a) and/or Section 12(b) above, or
Section 13 below, including the recovery of damages. 

        13.    Non-Disparagement.    During the Term of Employment and for the period of five (5) years
thereafter, the Executive agrees not to disparage or encourage or induce others to disparage the Company or any Subsidiary or any of their past and present employees, officers, directors, products or
services. For purposes of this Agreement, the term "disparage" includes, without limitation, comments or statements to the press, to the Company's or any Subsidiary's employees or to any individual or
entity with whom the Company or any Subsidiary has a business relationship (including, without limitation, any vendor, supplier, customer or distributor of the Company or any Subsidiary), or any
public statement, that would adversely affect in any manner, as applicable: (i) the conduct of any business of the Company or any Subsidiary (including,
without limitation, any business plans or prospects), or (ii) the business reputation of the Company or any Subsidiary. The Company shall request of its
Board members that they not disparage Executive except as they in good faith deem necessary or appropriate in fulfilling their fiduciary and legal obligations as directors. Notwithstanding the
foregoing, nothing in this Section 13 shall prevent any person from (x) responding publicly to incorrect, disparaging or derogatory public
statements to the extent, but only to the extent, reasonably necessary to correct or refute such public statement, or (y) making any truthful statement
to the extent, but only to the extent (i) necessary with respect to any litigation, arbitration or mediation involving this
Agreement, including, but not limited to, the enforcement of this Agreement, in the forum in which such litigation, arbitration or mediation properly takes place or (ii) required by law or by
any court, arbitrator, mediator or administrative or legislative body (including any committee thereof) with apparent jurisdiction over the Executive or
(z) making normal competitive statements during any period after the limitations in Section 12(a) cease to apply. 

        14.    Assignability; Binding Nature.    This Agreement shall be binding upon and inure to the benefit of the Parties
and their respective successors, heirs (in the case of the Executive) and assigns. The rights or obligations under this Agreement may be not be assigned or transferred by either party, except that
such rights or obligations may be assigned or transferred pursuant to a merger or 

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consolidation
in which the Company is not the continuing entity, or the sale or liquidation of all or substantially all of the assets of the Company; provided,
however, that the assignee or transferee is the successor to all or substantially all of the assets of the Company and such assignee or transferee assumes the liabilities,
obligations and duties of the company, as contained in this Agreement, either contractually or as a matter of law. 

        15.    Representation.    The Company represents and warrants that it is fully authorized and empowered to enter into
and perform its obligations under this Agreement, that the performance of its obligations under this Agreement will not violate any agreement between it and any other person, firm or organization, and
that upon the execution and delivery of this Agreement by the Executive and the Company, it shall be a valid and binding obligation of the Company enforceable against it in accordance with its terms,
except to the extent that enforceability may be limited by applicable bankruptcy, insolvency or similar laws affecting the enforcement of creditors' rights generally. The Executive represents and
warrants that no agreement, covenant, obligation or commitment exists between him and any other person, firm or organization that would be breached or violated by the execution of this Agreement or
the performance of his obligations hereunder, or would otherwise conflict with or preclude him from the performance of his obligations hereunder. The Executive acknowledges that he has had an
opportunity to consult with counsel of his choosing in connection with this Agreement. 

        16.    Entire Agreement.    This Agreement contains the entire understanding and agreement between the Parties
concerning the subject matter hereof and supersedes all prior agreements, understandings, discussions, negotiations and undertakings, whether written or oral, between the Parties with respect thereto. 

        17.    Amendment or Waiver.    No provision in this Agreement may be amended unless such amendment is agreed to in
writing and signed by the Executive and an authorized officer of the Company. No waiver by either Party of any breach by the other Party of any condition or provision contained in this Agreement to be
performed by such other Party shall be deemed a waiver of a similar or dissimilar condition or provision at the same or any prior or subsequent time. Any waiver must be in writing and signed by the
Executive or an authorized officer of the Company, as the case may be. 

        18.    Withholding.    The Company may withhold from any amounts payable under this Agreement such federal, state and
local taxes as may be required to be withheld pursuant to any applicable law or regulation. 

        19.    Severability.    In the event that any provision or portion of this Agreement shall be determined to be invalid
or unenforceable for any reason, in whole or in part, the remaining provisions of this Agreement shall be unaffected thereby and shall remain in full force and effect to the fullest extent permitted
by law. 

        20.    Survivorship.    The respective rights and obligations of the Parties hereunder shall survive any termination
of the Executive's employment hereunder to the extent necessary to the intended preservation of such rights and obligations. 

        21.    Beneficiaries/References.    The Executive shall be entitled, to the extent permitted under any applicable law,
to select and change a beneficiary or beneficiaries to receive any compensation or benefit payable hereunder following the Executive's death by giving the Company written notice thereof. In the event
of the Executive's death or a judicial determination of his incompetence, reference in this Agreement to the Executive shall be deemed, where appropriate, to refer to his beneficiary, estate or other
legal representative. 

        22.    Governing Law/Jurisdiction.    This Agreement shall be governed by and construed and interpreted in accordance
with the laws of the State of New York without reference to principles of conflict of laws unless superseded by federal law. 

10

 

        23.    Section 409A.    

        (a)   The
Parties hereto intend that all benefits and payments to be made to the Executive hereunder will be provided or paid to him in compliance with all applicable
provisions of section 409A of the Internal Revenue Code of 1986 as amended, and the regulations issued thereunder, and the rulings, notices and other guidance issued by the Internal Revenue
Services interpreting the same ("the Section 409A Rules"), and this Agreement shall be construed and administered in accordance with such intent. The Parties also agree that this Agreement may
be modified, as reasonably requested by either party, to the extent necessary to comply with all applicable requirements of, and to avoid the imposition of any additional tax, interest and penalties
under, the Section 409A Rules in connection with, the benefits and payments to be provided or paid to the Executive hereunder. Any such modification shall maintain the original intent and
benefit to the Company and the Executive of the applicable provision of this Agreement, to the maximum extent possible without violating the Section 409A Rules. 

        (b)   Notwithstanding
the foregoing or anything to the contrary contained in any other provision of this Agreement, if the Executive is a "specified employee" within the
meaning of the Section 409A Rules at the time of his "separation from service" within the meaning of the Section 409A Rules, then any payment hereunder designated as being subject to
this Section 23(b) shall not be made until the first business day after (i) the expiration of six (6) months from the date of his separation from service, or (ii) if
earlier, the date of his death (the "Delayed Payment Date"). On the Delayed Payment Date, there shall be paid to the Executive or, if he has died, to his estate, in a single cash lump sum, an amount
equal to aggregate amount of the payments delayed pursuant to the preceding sentence. 

        (c)   The
Executive's rights to receive the payments referred to in Section 10(d) or Section 10(e) above shall be treated as a right to a series of separate
payments under Treas. Reg. 1.409A-2(b)(2)(iii) for purposes of the Section 409A Rules. 

        24.    Venue.    Any unresolved dispute arising out of this Agreement shall be litigated in any court of competent
jurisdiction in the Borough of Manhattan in New York City; provided that the Company may elect to pursue a court action to seek injunctive relief in any court of competent jurisdiction to enforce
Sections 11, 12 and 13 of this Agreement. 

        25.    Notices.    All notices shall be in writing, shall be sent to the following addresses listed below by certified
mail, return receipt requested or using a reputable overnight express delivery service, and shall be deemed to be given when received. 

	If to the Company:	 	ImClone Systems Incorporated

180 Varick Street

New York, New York 10014

Attention: Chairman of the Board
	

 	
 	

with a copy to the General Counsel of the Company
	

If to the Executive:	
 	

The Executive's last known address on file with the Company

        26.    Headings.    The headings of the sections contained in this Agreement are for convenience only and shall not be
deemed to control or affect the meaning or construction of any provision of this Agreement. 

        27.    Counterparts.    This Agreement may be executed in two or more counterparts, and such counterparts shall
constitute one and the same instrument. Signatures delivered by facsimile shall be deemed effective for all purposes to the extent permitted under applicable law. 

11

 

        28.    Indemnification.    During the Term of Employment and thereafter, the Company shall (i) indemnify and
hold the Executive and his heirs and representatives harmless to the extent permitted in the Company's by-laws in effect from time to time to the same extent as other senior level
executives and other directors receive from the Company, and (ii) cover the Executive under directors and officers insurance policies maintained by the Company, if any, for its other officers
and directors. 

REMAINDER OF PAGE INTENTIONAL LEFT BLANK

12

 

        IN
WITNESS WHEREOF, the undersigned have executed this Agreement as of the date first written above. 

	 	 	IMCLONE SYSTEMS INCORPORATED
	 	 	 	 	 
	 	 	 	 	 
	 	 	By:	 	/s/ Alexander J. Denner
 Name:  Alexander J. Denner, Ph.D.

Title:    Chairman, Executive Committee
	 	 	 	 	 
	 	 	 	 	 
	 	 	/s/ John H. Johnson
 John H. Johnson

13

   SCHEDULE A  

RELEASE  

        This RELEASE ("Release") dated as of
this                        day between ImClone Systems Incorporated, a Delaware corporation (the "Company"), and John H. Johnson
(the "Executive"). 

        WHEREAS,
the Company and the Executive previously entered into an employment agreement dated August 6, 2007 under which the Executive was employed to serve as the Company's Chief
Executive Officer (the "Employment Agreement"); and 

        WHEREAS,
the Executive's employment with the Company (has been) (will be) terminated effective                        ; and 

        WHEREAS,
pursuant to Section 10 of the Employment Agreement, the Executive is entitled to certain compensation and benefits upon such termination, contingent upon the execution of
this Release; 

        NOW,
THEREFORE, in consideration of the premises and mutual agreements contained herein and in the Employment Agreement, the Company and the Executive agree as follows: 

        1.     Subject
to Paragraph 3 below, the Executive, on his own behalf and on behalf of his heirs, estate and beneficiaries, does hereby release the Company, and any of
its Subsidiaries or affiliates, and, in their respective capacities as such, each past or present officer, director, agent, employee shareholder and insurer of any such entities, from any and all
claims made, to be made, or which might have been made of whatever nature, whether known or unknown, from the beginning of time, including those that arose as a consequence of or related to his
employment with the Company, or arising out of or relating to the severance of such employment relationship, or arising out of or related to any act committed or omitted during or after the existence
of such employment relationship, all up through and including the date on which this Release is executed, which shall not be earlier than the date of the Executive's termination of employment, but not
limited to, those which were, could have been or could be the subject of an administrative or judicial proceeding filed by the Executive or on his behalf under federal, state or local law, whether by
statute, regulation, in contract or tort, and including but not limited to, every claim for front pay, back pay, wages, bonus, fringe benefit, any form of discrimination (including but not limited to,
every claim of race, color, sex, religion, national origin, disability or age discrimination), wrongful termination, emotional distress, pain and suffering, breach of contract or compensatory or
punitive damages, interest, attorney's fees, reinstatement or reemployment, and claims under Title VII of the Civil Rights Act of 1964, the Civil Rights Act of 1991, the Age Discrimination in
Employment Act ("ADEA"), the Older Workers Benefit Protection Act ("OWBPA"), the Americans with Disabilities Act, the Employment Retirement Income Security Act of 1974, the Family and Medical Leave
Act, the Equal Pay Act, the Worker Adjustment and Retraining Notification Act, the National Labor Relations Act, the Fair Labor Standards Act, the Sarbanes-Oxley Act of 2002, each and every state or
local variation of these federal laws including without limitation the New York State Human Rights Law, the New York City Human Rights Law, the New York Labor Law, the New York Civil Rights Law, the
Delaware Employment Discrimination Law, the the New Jersey Law Against Discrimination, the New Jersey Conscientious Employee Protection Act, the New Jersey Equal Pay Act, and the New Jersey Family
Leave Act, all as amended, and any and all other applicable federal, state, and local fair employment practices laws, individual or constitutional rights, and wage or discrimination laws (statutory or
decisional). If any court rules that such waiver of rights to file, or have filed on his behalf, any administrative or judicial charges or complaints is ineffective, the Executive agrees not to seek
or accept any money damages or any other relief upon the filing of any such administrative or judicial charges or complaints. The Executive relinquishes any right to future employment with the Company
and the Company shall have the right to refuse to re-employ the Executive without liability. 

14

 

The
Executive acknowledges and agrees that even though claims and facts in addition to those now known or believed by him to exist may subsequently be discovered, it is his intention to fully settle
and release all such claims he may have against the Company and the persons and entities described above, whether known, unknown or suspected. 

        2.     The
Company acknowledges and agrees that the release contained in Paragraph 1 does not, and shall not be construed to, release or limit the scope of any
(i) obligation of the Company to indemnify the Executive for his acts as an officer or director of Company in accordance with the bylaws of Company and the policies and procedures of Company,
or pursuant to any directors and officers liability insurance policy, (ii) obligation of the Company under any existing welfare, retirement, fringe-benefit or other plan or program of the
Company in which the Executive and/or such dependents are participants, and (iii) any right the Executive may have to enforce this Agreement or the Employment Agreement. Additionally, by
executing this Agreement, Executive is not waiving any claim that may not be released by law, or Executive's right to file a charge with or participate in any investigation or proceeding
conducted by the U.S. Equal Employment Opportunity Commission or other government agency, except that even if Executive files a charge or participates in such an investigation or proceeding, Executive
will not be able to recover damages or equitable relief of any kind from the Company or other parties released pursuant to Section 1. 

        3.     The
Executive acknowledges that he has been provided at least 21 days to review the Release and has been advised to review it with an attorney of his choice. In
the event the Executive elects to sign this Release prior to this 21 day period, he agrees that it is a knowing and voluntary waiver of his right to wait the full 21 days. The Executive
further understands that he has 7 days after the signing hereof to revoke it by so notifying the Company in writing, such notice to be received
by                        within the 7-day
period. The Executive further acknowledges that he has carefully read this Release, and knows and understands its contents and its binding legal effect. The Executive acknowledges that by signing this
Release, he does so of his own free will and act and that it is his intention that he be legally bound by its terms. 

        IN
WITNESS WHEREOF, the parties have executed this Release on the date first above written. 

	 	 	IMCLONE SYSTEMS INCORPORATED
	

 	
 	

By:	
 	

    
 Name:

Title:
	

 	
 	

    
 John H. Johnson

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Exhibit 4.3    
    

THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE "ACT") AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED,
ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION
IS NOT REQUIRED.

 
 

CARDIONET, INC.
  
    WARRANT TO PURCHASE PREFERRED STOCK    
    

	No. PSW-22	 	May 30, 2006

        THIS CERTIFIES THAT, for value received, GUIDANT INVESTMENT CORPORATION (the  "Holder"), is entitled to subscribe
for and purchase at the Warrant Price (as defined below) from  CARDIONET, INC., a California corporation (the "Company"), up to such number and
series of fully
paid and nonassessable shares of Preferred Stock of the Company (or such other number, class and kind of shares as may be issuable hereunder pursuant to Section 4 below) (the
"Shares") as set forth herein, during the Exercise Period (as defined below). 

        This
Warrant is issued pursuant to the Letter Agreement of even date herewith between the Company and Holder (the "Letter Agreement").
Pursuant to the Letter Agreement, the Company also issued Holder an Amended and Restated Subordinated Promissory Note of even date herewith (the "Note")
in the principal amount of $21,400,958.04. 

        On
May 1, 2006, the Company issued a series of Amended and Restated Secured Subordinated Convertible Promissory Notes in the aggregate principal amount of $3,161,643.84 to certain
investors, the form of which is attached to this Warrant as Exhibit A (collectively, as the same may be amended from time to time, the  "Bridge Notes"). 

1.    EXERCISE OF WARRANT.    The terms and conditions upon which this Warrant may
be exercised, and the Shares covered hereby may be purchased, are as follows: 

        (a)   Term. Subject to the terms and conditions hereof, this Warrant may be exercised at any time, or from time to time, in
whole or in part, on or after the earlier of (i) the optional conversion of the Bridge Notes at the Next Equity Financing (as defined in the Bridge Notes) or (ii) the Maturity Date (as
defined in the Bridge Notes); provided, however, that in no event may this Warrant be exercised after 5:00 p.m. Pacific Time, on the date five
years following the date hereof (the "Exercise Period"). 

        (b)   Series of Preferred Stock. The series of Preferred Stock of the Company for which this Warrant shall be exercisable shall
be (i) if a Next Equity Financing occurs on or prior to the Maturity Date, the equity securities sold in a Next Equity Financing or (ii) if no Next Equity Financing occurs on or prior to
the Maturity Date, shares of the Company's Series D-1 Preferred (as defined below). 

        (c)   Number of Shares. The number of Shares for up to which this Warrant may be exercisable shall be determined by dividing
the Warrant Coverage Amount (as defined below) by the Warrant Price (as defined below). 

        (i)    As used herein, the "Warrant Coverage Amount" shall mean $1,400,958.04
multiplied by 0.50. 

                (ii)   As used herein, "Warrant Price" shall mean (a) the
per share price of securities into which the Bridge Notes are converted upon the optional conversion of the Bridge Notes at the Next Equity Financing or (b) $3.50 (as adjusted stock dividends,
combinations, splits and other recapitalizations after the date hereof) if the Warrant becomes exercisable for shares of the Company's Series D-1 Preferred. 

2.    METHOD OF EXERCISE.    

        (a)   The rights represented by this Warrant may be exercised in whole or in part at any time during the Exercise Period, by
delivery of the following to the Company at its address set forth in the Purchase Agreement (or at such other address as it may designate by notice in writing to the Holder): 

        (i)    An executed Notice of Exercise in the form attached hereto as  Exhibit B; 

                (ii)   Payment of the Warrant Price either (a) in cash or by check or (b) by cancellation of
indebtedness or (c) by any combination thereof; and 

        (iii) This Warrant. 

        Upon
the exercise of the rights represented by this Warrant, a certificate or certificates for the Shares so purchased, registered in the name of the Holder or persons affiliated with
the Holder, if the Holder so designates, shall be issued and delivered to the Holder promptly after the rights represented by this Warrant shall have been so exercised. 

        The
person in whose name any certificate or certificates for Shares are to be issued upon exercise of this Warrant shall be deemed to have become the holder of record of such Shares on
the date on which this Warrant was surrendered and payment of the Warrant Price was made, irrespective of the date of delivery of such certificate or certificates, except that, if the date of such
surrender and payment is a date when the stock transfer books of the Company are closed, such person shall be deemed to have become the holder of such Shares at the close of business on the next
succeeding date on which the stock transfer books are open. 

        (b)   Net Exercise. Notwithstanding any provisions herein to the contrary, if the Fair Market Value (as defined below) of one
Share is greater than the Warrant Price (at the date of calculation as set forth below), in lieu of exercising this Warrant by payment of cash, the Holder may elect to receive Shares equal to the
value (as determined below) of this Warrant (or the portion thereof being canceled) by surrender of this Warrant at the principal office of the Company together with the properly endorsed Notice of
Exercise, in which event the Company shall issue to the Holder a number of Shares computed using the following formula: 

	X =	Y (A-B)
 A

	Where:	 	X =	 	the number of Shares to be issued to the Holder
	

 	
 	

Y =	
 	

the number of Shares purchasable under the Warrant or, if only a portion of the Warrant is being exercised, the portion of the Warrant being canceled (at the date of such calculation)
	

 	
 	

A =	
 	

the fair market value of one Share (at the date of such calculation)
	

 	
 	

B =	
 	

the Warrant Price (as adjusted to the date of such calculation)

        For
purposes of this Warrant, the fair market value of one Share (the "Fair Market Value") shall mean, with respect to each such Share, 

        (A)  if
the exercise is in connection with an initial public offering of the Company's Common Stock, and if the Company's registration statement relating to such public
offering has been declared effective by the Securities and Exchange Commission, then the Fair Market Value shall be the product of (x) the initial "Price to Public" per share specified in the
final prospectus with respect to the offering and (y) as applicable, the number of shares of Common Stock into which each such Share is convertible at the date of calculation; 

        (B)  if
this Warrant is exercised after, and not in connection with, the initial public offering of the Company's Common Stock, and if the Company's Common Stock is traded on
a securities exchange or The Nasdaq Stock Market or actively traded over-the-counter: 

        (1)   if
the Company's Common Stock is traded on a securities exchange or The Nasdaq Stock Market, the Fair Market Value shall be deemed to be the product of (x) the
average of the closing prices over the 20 day period ending three days before the date of calculation and (y) as applicable, the number of shares of Common Stock into which each such
Share is convertible on such date; or 

        (2)   if
the Company's Common Stock is actively traded over-the-counter, the Fair Market Value shall be deemed to be the product of (x) the
average of the closing bid or sales price (whichever is applicable) over the 20 day period ending three days before the date of calculation and (y) as applicable, the number of shares of
Common Stock into which each such Share is convertible on such date; or 

        (C)  if
neither (A) nor (B) is applicable, the Fair Market Value of such share shall be determined by the Company's Board of Directors in good faith. 

3.    COVENANTS OF THE COMPANY.    

        (a)   Covenants as to Shares. The Company covenants and agrees that all Shares that may be issued upon the exercise of the
rights represented by this Warrant will, upon issuance, be validly issued and outstanding, fully paid and nonassessable, and free from all taxes, liens and charges with respect to the issuance thereof
(other than taxes, liens or charges created by or imposed upon the Holder through no action of the Company). The Company further covenants and agrees that the Company will at all times during the
Exercise Period have authorized and reserved a sufficient number of shares to provide for the exercise of the rights represented by this Warrant. If at any time during the Exercise Period the number
of authorized but unissued shares shall not be sufficient to permit exercise of this Warrant, the Company will take such corporate action as may, in the opinion of its counsel, be necessary to
increase its authorized but unissued shares to such number of shares as shall be sufficient for such purposes. 

        (b)   Covenant to Create Series D-1 Preferred Stock. The Company hereby covenants and agrees that if no Next
Equity Financing has occurred prior to the Maturity Date, the Company shall use its best reasonable efforts to (A) cause its Articles of Incorporation (the  "Articles") to be amended at or
prior to the Maturity Date in order to authorize and reserve for issuance a series of Preferred Stock (the  "Series D-1 Preferred") on terms substantially similar to the Company's
Series C Preferred Stock, including the
Series C Original Purchase Price and Series C Conversion Price (as such terms are defined in the Articles) in effect as of the Maturity Date, but superior to all authorized series of the
Company's Preferred Stock (including the Series C Preferred Stock) in payment of dividends and liquidation preference and (B) reserve a sufficient number of shares of
Series D-1 Preferred for issuance upon exercise of the Warrant. 

        (c)   No Impairment. Except and to the extent as waived or consented to by the Holder in accordance with Section 11
below, the Company will not, by amendment of its Articles or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but will at all times in good faith assist in the carrying out of
all the provisions of this Warrant and in the taking of all such action as may be necessary or appropriate in order to protect the exercise rights of the Holder against impairment. 

        (d)   Notices of Record Date. In the event of any taking by the Company of a record of the holders of any class of securities
for the purpose of determining the holders thereof who are entitled to receive any dividend or other distribution, the Company shall mail to the Holder, at least 20 days prior to the date
specified herein, a notice specifying the date on which any such record is to be taken for the purpose of such dividend or distribution. 

4.    ADJUSTMENT OF WARRANT PRICE.    In the event of changes in the outstanding
Preferred Stock of the Company by reason of stock dividends, split-ups, recapitalizations, reclassifications, conversions, combinations or exchanges of shares, separations,
reorganizations, liquidations, or the like, the number and class of shares available under the Warrant in the aggregate and the Warrant Price shall be correspondingly adjusted to give the Holder of
the Warrant, on exercise for the same aggregate Warrant Price, the total number, class, and kind of shares as the Holder would have owned had the Warrant been exercised prior to the event and had the
Holder continued to hold such shares until after the event requiring adjustment. 

5.    ADJUSTMENT CERTIFICATE.    When any adjustment is required to be made in the
Shares or the Warrant Price pursuant to Section 4 or otherwise, the Company shall promptly mail to the Holder a certificate setting forth (i) a brief statement of the facts requiring
such adjustment, (ii) the Warrant Price after such adjustment and (iii) the kind and amount of stock or other securities or property into which this Warrant shall be exercisable after
such adjustment. In addition, at such time after the date hereof as the Company determines the series of Preferred Stock and number of Shares for which this Warrant shall be exercisable and the
Warrant Price, it shall deliver to the Holder a supplement setting forth such series, number of Shares and Warrant Price. 

6.    FRACTIONAL SHARES.    No fractional shares shall be issued upon the exercise
of this Warrant as a consequence of any adjustment pursuant hereto. All Shares (including fractions) issuable upon exercise of this Warrant may be aggregated for purposes of determining whether the
exercise would result in the issuance of any fractional share. If, after aggregation, the exercise would result in the issuance of a fractional share, the Company shall, in lieu of issuance of any
fractional share, pay the Holder otherwise entitled to such fraction a sum in cash equal to the product resulting from multiplying the then current Fair Market Value of a Share by such fraction. 

7.    EARLY TERMINATION.    In the event of, at any time during the Exercise Period,
an initial public offering of securities of the Company registered under the Securities Act of 1933, as amended, or a Disposition Transaction (as defined in the Bridge Notes), the Company shall
provide to the Holder 20 days advance written notice of such public offering or Disposition Transaction and this Warrant shall be deemed exercised pursuant to Section 2(b) above
immediately prior to the date such public offering is closed or the closing of such Disposition Transaction. 

8.    NO SHAREHOLDER RIGHTS.    This Warrant in and of itself shall not entitle the
Holder to any voting rights or other rights as a shareholder of the Company. 

9.    LOST, STOLEN, MUTILATED OR DESTROYED WARRANT.    If this Warrant is lost,
stolen, mutilated or destroyed, the Company shall, on such terms as to indemnity or otherwise as it may reasonably impose (which shall, in the case of a mutilated Warrant, include the surrender
thereof), issue a new Warrant of like denomination and tenor as the Warrant so lost, stolen, mutilated or destroyed. Any such new Warrant shall constitute an original contractual obligation of the
Company, whether or not the allegedly lost, stolen, mutilated or destroyed Warrant shall be at any time enforceable by anyone. 

10.    GOVERNING LAW.    This Warrant and all rights, obligations and liabilities
hereunder shall be governed by the laws of the State of California. 

11.    AMENDMENT; WAIVER.    Any term of this Warrant may be amended or waived with
the written consent of the Company and the Holder. 

12.    COUNTERPARTS.    This Warrant may be executed in one or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

        IN WITNESS WHEREOF, the Company has caused this WARRANT to be executed by its duly
authorized officer as of the date first written above. 

	 	 	 	CARDIONET, INC.
	

 	

 	
 	

By:	

/s/  JAMES M. SWEENEY      

	 	 	 	Name:	JAMES M. SWEENEY

	 	 	 	Title:	Chairman & CEO

	
Acknowledged and Accepted:	
 	

 	

 
	
GUIDANT INVESTMENT CORPORATION	
 	

 	

 
	

By:	

/s/  KEITH E. BRAUER      
	
 	

 	

 
	Name:	KEITH E. BRAUER
	 	 	 
	Title:	V.P. Finance and CFO
	 	 	 
	

  	

 	
 	

 	

 
	

  	

 	
 	

 	

 
	

  	

 	
 	

 	

 
	

  	

 	
 	

 	

 
	

  	

 	
 	

 	

 
	

  	

 	
 	

 	

 

[SIGNATURE PAGE TO WARRANT] 

 
 

EXHIBIT A
  
    FORM OF BRIDGE NOTE  
  

 
 

Exhibit B
  
    NOTICE OF EXERCISE  
  

TO: CARDIONET, INC.

        (1)   o The
undersigned hereby elects to purchase            Shares of  CARDIONET, INC. (the "Company") pursuant to the terms of the attached Warrant, and tenders
herewith payment of the exercise price in full, together with all applicable transfer taxes, if any. 

                o The
undersigned hereby elects to purchase            Shares of  CARDIONET, INC. (the "Company") pursuant to the terms of the net exercise provisions set forth in
Section 2(b) of the attached Warrant, and shall tender payment of all applicable transfer taxes, if any. 

        (2)   Please
issue a certificate or certificates representing said shares of Preferred Stock in the name of the undersigned or in such other name as is specified below: 

	  
 (Name)
	

  
  
 (Address)

        (3)   The
undersigned represents that (i) the aforesaid Shares are being acquired for the account of the undersigned for investment and not with a view to, or for
resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares; (ii) the undersigned is aware of the Company's
business affairs and financial condition and has acquired sufficient information about the Company to reach an informed and knowledgeable decision regarding its investment in the Company;
(iii) the undersigned is experienced in making investments of this type and has such knowledge and background in financial and business matters that the undersigned is capable of evaluating the
merits and risks of this investment and protecting the undersigned's own interests; (iv) the undersigned understands that the Shares issuable upon exercise of this Warrant have not been
registered under the Securities Act of 1933, as amended (the "Act"), by reason of a specific exemption from the registration provisions of the Act,
which exemption depends upon, among other things, the bona fide nature of the investment intent as expressed herein, and, because such securities have not been registered under the Act, they must be
held indefinitely unless subsequently registered under the Act or an exemption from such registration is available; (v) the undersigned is aware that the aforesaid Shares may not be sold
pursuant to Rule 144 adopted under the Act unless certain conditions are met and until the undersigned has held the shares for the number of years prescribed by Rule 144, that among the
conditions for use of the Rule is the availability of current information to the public about the Company and the Company has not made such information available and has no present plans to do so; and
(vi) the undersigned agrees not to make any disposition of all or any part of the aforesaid Shares unless and until there is then in effect a registration statement under the Act covering such
proposed disposition and such disposition is made in accordance with said registration statement, or the undersigned has provided the Company with an opinion of counsel satisfactory to the Company,
stating that such registration is not required. 

	            
 (Date)	 	            
 (Signature)
	

 	
 	

            
 (Print name)

 
 

Exhibit C
  
    FORM OF ASSIGNMENT  
  

	(To assign the foregoing Warrant, execute this form

and supply required information. Do not use this

form to purchase shares.)

        FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to: 

	Name:	  
 (Please Print)

	

Address:	

  
 (Please Print)      

	

Dated:	

  
	

, 200	

  
	
 	

 

	

Holder's

Signature:	

  
	

 

	

Holder's

Address:	
 	

  

NOTE: The signature to this Form of Assignment must correspond with the name as it appears on the face of the Warrant, without alteration or
enlargement or any change whatever. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of authority to assign the foregoing Warrant. 

QuickLinks

Exhibit 4.3

CARDIONET, INC. WARRANT TO PURCHASE PREFERRED STOCK

EXHIBIT A FORM OF BRIDGE NOTE

Exhibit B NOTICE OF EXERCISE

Exhibit C FORM OF ASSIGNMENT

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