Document:

EX-10.4

 Exhibit 10.4 

FIRST AMENDMENT TO 
 WARRANT
AGREEMENT 
 Zosano Pharma Corporation 

Dated as of June 23, 2015 (the “Effective Date”) 

This First Amendment to Warrant Agreement (the “Amendment”) is dated as of June 23, 2015, by and between Zosano Pharma
Corporation, a Delaware corporation formerly named ZP Holdings, Inc. (the “Company”), and Hercules Technology Growth Capital, Inc., a Maryland corporation (“Hercules”). 

WHEREAS, ZP Opco, Inc., a Delaware corporation formerly named Zosano Pharma, Inc. (“ZP Opco”), is a wholly-owned subsidiary of the
Company; 
 WHEREAS, ZP Opco has entered into a Loan and Security Agreement dated as of June 3, 2014 (the “Original Loan
Agreement”), as amended pursuant to that certain First Amendment to Loan and Security Agreement dated as of June 23, 2015 (collectively, the “Loan Agreement”) with Hercules and the other lender parties thereto; 

WHEREAS, in connection the Original Loan Agreement, the Company and Hercules entered into a Warrant Agreement dated as of June 3, 2014
(the “Original Warrant”), and the parties hereto desire to clarify Section 2(b) of the Original Warrant. 
 NOW,
THEREFORE, in consideration of Hercules’s executing and delivering the Loan Agreement and providing the financial accommodations contemplated therein, and in consideration of the mutual covenants and agreements contained herein, the Company and
Hercules agree as follows: 
 1. Capitalized terms used but not defined herein shall have the meaning provided in the Original Warrant. 

2. Section 2(b) of the Original Warrant is hereby amended and restated in its entirety to provide: 

(b) Early Termination. The Company shall provide written notice to the registered holder of this Agreement of a
Qualified Merger Event at least ten days prior to the consummation of the Merger Event. Notice from the Company to the registered holder of this Agreement of a Qualified Merger Event shall provide detailed information regarding the consideration to
be received by holders of Company Stock in connection with such Qualified Merger Event. In the event of a Qualified Merger Event where the registered holder of this Agreement elects not to exercise its rights under this Agreement to acquire shares
of Company Stock in connection with the Qualified Merger Event, then the Company may elect to pay to the registered holder of this Agreement, at closing of such Qualified Merger Event, an amount in cash equal to one (1) times the aggregate
Exercise Price for the number of shares of Company Stock acquirable under this Agreement as of the date of such Qualified Merger Event (i.e., the Exercise Price per share times the number of shares of Company Stock acquirable under this Agreement as
of the date of such Qualified Merger Event) and this Agreement shall be terminated effective upon receipt of such payment, which payment shall be in complete satisfaction hereof. 

3. Except as provided herein, the Original Agreement remain unchanged, and in full force and effect in accordance with its terms. 

4. This Amendment may be executed in any number of counterparts, each of which when so executed and delivered shall be deemed an original and
all of which counterparts, taken together, shall constitute one and the same instrument. The provisions of Section 12 of the Original Warrant shall be deemed incorporated herein by reference, mutatis mutandis. 

[Remainder of Page Intentionally Left Blank] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this First Amendment to Warrant Agreement to
be executed by its officers thereunto duly authorized as of the Effective Date. 
  

							
	                COMPANY:				Zosano Pharma Corporation
				
					By:		 /s/ Vikram Lamba

					Name: Vikram Lamba
					Title: President
			
	                HERCULES:				HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
				
					By:		 /s/ Ben Bang

					Name: Ben Bang
					Title: Associate General Counsel

  
 2EX-10.5

 Exhibit 10.5 

SIXTH AMENDMENT TO LEASE 

THIS SIXTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
24th day of June, 2015, by and between BMR-34790 ARDENTECH COURT LP, a Delaware limited partnership (“Landlord,” as successor-in-interest to BMR-34790 Ardentech Court LLC), and ZP
OPCO, INC., a Delaware corporation (“Tenant,” formerly known as Zosano Pharma, Inc. and, previously, The Macroflux Corporation). 

RECITALS 
 A.
WHEREAS, Landlord and Tenant are parties to that certain Lease dated as of May 1, 2007 (the “Original Lease”), as amended by that certain First Amendment to Lease dated as of June 20, 2008, that certain Second Amendment to
Lease dated as of October 16, 2008, that certain Third Amendment to Lease dated as of April 29, 2011, that certain Fourth Amendment to Lease dated as of July 31, 2011, and that certain Fifth Amendment to Lease dated as of
April 1, 2012 (collectively, and as the same may have been further amended, amended and restated, supplemented or modified from time to time, the “Existing Lease”), whereby Tenant leases certain premises (the
“Premises”) from Landlord at 34790 Ardentech Court in Fremont, California (the “Building”); 
 B. WHEREAS,
Landlord and Tenant desire to provide Tenant with an Option to Extend and pay rent on the Total Premises; and 
 C. WHEREAS, Landlord and
Tenant desire to modify and amend the Existing Lease only in the respects and on the conditions hereinafter stated. 
 AGREEMENT

 NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1.
Definitions. For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Existing Lease unless otherwise defined herein. The Existing Lease, as amended by this Amendment, is referred to collectively
herein as the “Lease.” From and after the date hereof, the term “Lease,” as used in the Existing Lease, shall mean the Existing Lease, as amended by this Amendment. 

2. Option to Extend. Tenant shall have the option (the “Option”) to extend the Term by an additional thirty eight
(38) months for a Term Expiration Date of June 1, 2022 and pay rent on the Total Premises upon the following terms and conditions. Any extension of the Term pursuant to the Option shall be on all the same terms and conditions as the Lease,
except as follows: 

 2.1. If Tenant chooses to exercise the Option, Basic Annual Rent will be paid in accordance with
the following schedule: 
  

																	
	 Dates
	  	Square Feet
of Total
Premises	 	  	*Base Rent per
Square Foot of
Rentable Area	 	  	Monthly Base
Rent	 	  	Annual Base Rent	 
	 January 1, 2016-March 31, 2016
	  	 	55,588	  	  	$	.90	  	  	$	50,118.40	  	  	$	150,355.20	  
	 April 1, 2016-March 31, 2017
	  	 	55,588	  	  	$	1.85	  	  	$	102,980.95	  	  	$	1,235,771.42	  
	 April 1, 2017- March 31, 2018
	  	 	55,588	  	  	$	1.91	  	  	$	106,070.38	  	  	 	1,272,844.57	  
	 April 1, 2018-March 31, 2019
	  	 	55,588	  	  	$	1.97	  	  	$	109,252.49	  	  	$	1,311,029.90	  
	 April 1, 2019-March 31, 2020
	  	 	55,588	  	  	$	2.30	  	  	$	127,852.40	  	  	$	1,534,228.80	  
	 April 1, 2020-March 31, 2021
	  	 	55,588	  	  	$	2.37	  	  	$	131,687.97	  	  	$	1,580,255.66	  
	 April 1, 2021-March 31 2022
	  	 	55,588	  	  	$	2.44	  	  	$	135,638.61	  	  	$	1,627,663.33	  
	 April 1, 2022- May 31, 2022
	  	 	55,588	  	  	$	2.51	  	  	$	139,707.77	  	  	$	279,415.54	  

  

	*	Numbers are rounded due to combining of Premises. 

 2.2 If Tenant chooses to exercise the
Option, Landlord shall provide a maintenance allowance (the “Maintenance Allowance”) of TWO HUNDRED THOUSAND DOLLARS ($200,000). Tenant acknowledges that the Maintenance Allowance may only be used to pay for the maintenance and
repair of existing building systems. Landlord’s obligation to fund the Maintenance Allowance shall expire on December 31, 2016. 

2.3 The Option is not assignable separate and apart from this Lease. 

2.4 The Option is conditional upon Tenant giving Landlord written notice of its election to exercise the Option before December 31, 2015.
Tenant assumes full responsibility for maintaining a record of the deadlines to exercise the Option. Tenant acknowledges that it would be inequitable to require Landlord to accept any exercise of the Option after the date provided for in this
Section 2.4. 

  
 2 

 2.5 Notwithstanding anything contained in this Article 2 to the contrary, Tenant shall not have
the right to exercise the Option: 
 2.5.1. During the time commencing from the date Landlord delivers to Tenant a written notice that
Tenant is in default under any provisions of the Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or 

2.5.2. At any time after any default as described in Article 24 of the Lease (provided, however, that, for purposes of this Subsection 2.5.2,
Landlord shall not be required to provide Tenant with notice of such default) and continuing until Tenant cures any such default, if such default is susceptible to being cured; or 

2.5.3. In the event that Tenant has defaulted in the performance of its obligations under the Lease two (2) or more times and a service
or late charge has become payable for each of such defaults during the twelve (12) month period immediately prior to the date that Tenant intends to exercise the Option, whether or not Tenant has cured such defaults. 

2.6 The period of time within which Tenant may exercise the Option shall not be extended or enlarged by reason of Tenant’s inability to
exercise such Option because of the provisions of Section 2.5 above. 
 2.7 All of Tenant’s rights under the provisions of the
Option shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Option if, after such exercise, but prior to January 1, 2016, (a) Tenant fails to pay to Landlord a monetary obligation of
Tenant for a period of twenty (20) days after written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty (30) days after the date Landlord gives notice to
Tenant of such default or (c) Tenant has defaulted under the Lease two (2) or more times and a service or late charge has become payable for any such default, whether or not Tenant has cured such defaults. 

2.8 Effective the date of this Amendment, Landlord’s right to recapture the Recapturable Premises pursuant to Section 3 of the Fifth
Amendment to Lease shall be suspended. If Tenant exercises the Option in accordance with Section 2 of this Amendment, then Landlord’s right to recapture the Recapturable Premises pursuant to Section 3 of the Fifth Amendment to Lease
shall terminate effective January 1, 2016 and be of no further force or effect. If Tenant does not exercise the Option in accordance with Section 2 of this Amendment, then Landlord’s right to recapture the Recapturable Premises
pursuant to Section 3 of the Fifth Amendment to Lease shall be reinstated effective January 1, 2016, and Basic Annual Rent shall be as set forth in the Fifth Amendment to Lease. 

  
 3 

 3. Condition of Premises. Tenant acknowledges that (a) it is in possession of and is
fully familiar with the condition of the Premises and, notwithstanding anything contained in the Lease to the contrary, agrees to take the same in its condition “as is” as of the first day of the Extension Term, and (b) Landlord shall
have no obligation to alter, repair or otherwise prepare the Premises for Tenant’s continued occupancy for the Extension Term or to pay for any improvements to the Premises, except as may be expressly provided in the Lease. 

4. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of
this Amendment and agrees to reimburse, indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord, at Tenant’s sole cost and expense) and hold harmless the Landlord Indemnitees for, from and against
any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by it or claiming to have been employed or engaged by it. 

5. No Default. Tenant represents, warrants and covenants that, to the best of Tenant’s knowledge, Landlord and Tenant are not in
default of any of their respective obligations under the Existing Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. 

6. Notices. Tenant confirms that, notwithstanding anything in the Lease to the contrary, notices delivered to Tenant pursuant to the
Lease should be sent to: 
 ZP Opco, Inc. 

34790 Ardentech Court 
 Fremont,
CA 94555-3657 
 Attention: Vikram Lamba 

with a copy to: 
 Foley Hoag LLP

 155 Seaport Boulevard 

Boston, Massachusetts 02210 

Attention: Jeffrey L. Quillen, Esq. 

7. Effect of Amendment. Except as modified by this Amendment, the Existing Lease and all the covenants, agreements, terms, provisions
and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. In the event of any conflict between the terms contained in this Amendment and the Existing Lease, the terms herein contained shall supersede and
control the obligations and liabilities of the parties. 
 8. Successors and Assigns. Each of the covenants, conditions and
agreements contained in this Amendment shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs, legatees, devisees, executors, administrators and permitted successors and assigns and
sublessees. Nothing in this section shall in any way alter the provisions of the Lease restricting assignment or subletting. 

  
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 9. Miscellaneous. This Amendment becomes effective only upon execution and delivery hereof
by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits hereto are
incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or otherwise until execution by
and delivery to both Landlord and Tenant. 
 10. Authority. Tenant guarantees, warrants and represents that the individual or
individuals signing this Amendment have the power, authority and legal capacity to sign this Amendment on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and
entities on whose behalf such individual or individuals have signed. 
 11. Counterparts; Facsimile and PDF Signatures. This
Amendment may be executed in one or more counterparts, each of which, when taken together, shall constitute one and the same document. A facsimile or portable document format (PDF) signature on this Amendment shall be equivalent to, and have the
same force and effect as, an original signature. 
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 5 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the date and year
first above written. 
  

			
	LANDLORD:
	
	 BMR-34790 ARDENTECH COURT LP,
 a
Delaware limited partnership

		
	By:		 /s/ Brian Wolfe

	Name:		Brian Wolfe
	Title:		Vice President
	
	TENANT:
	
	 ZP OPCO, INC.,
 a Delaware
corporation

		
	By:		 /s/ Vikram Lamba

	Name:		Vikram Lamba
	Title:		CEO

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