Document:

First Amendment to Rights Agreement

 Exhibit 4.1 
 FIRST AMENDMENT TO RIGHTS AGREEMENT 
 This FIRST AMENDMENT, dated as of January 11, 2009, (this
“Amendment”), amends the Rights Agreement (the “Agreement”), dated as of June 24, 2002, by and between Advanced Medical Optics, Inc., a Delaware corporation (the “Company”) and Mellon Investor Services LLC, a New
Jersey limited liability company (the “Rights Agent”). All capitalized terms used herein but not otherwise defined shall have the meanings ascribed thereto in the Agreement. 
 WHEREAS, Abbott Laboratories, an Illinois corporation (“Parent”), Rainforest Acquisition Inc., a newly formed Delaware corporation and wholly
owned subsidiary of Parent (the “Purchaser”), and the Company are entering into an Agreement and Plan of Merger (the “Merger Agreement”), dated as of the date hereof, pursuant to which (i) the Purchaser will commence a cash
tender offer (the “Offer”) to purchase all of the issued and outstanding shares of common stock, par value $.01 per share, of the Company (the “Common Stock”) and (ii) following consummation of the Offer, Purchaser will
merge with and into the Company with the Company surviving as a wholly owned subsidiary of Parent (the “Merger”); 
 WHEREAS,
concurrently with the execution of the Merger Agreement, (i) Parent and ValueAct Capital Master Fund, L.P, ValueAct Capital Master Fund III, L.P, and Mason Morfit (collectively “ValueAct”) are entering into tender and support
agreements, pursuant to which, among other things, ValueAct will tender its shares of Common Stock in the Offer; and (ii) Parent and James V. Mazzo (“Mazzo”) are entering into tender and support agreements (collectively, the
“Tender and Support Agreements”), pursuant to which, among other things, Mazzo will tender its shares of Common Stock in the Offer; 
 WHEREAS, pursuant to resolutions adopted January 11, 2009 (the “Resolutions”), the board of directors of the Company has approved (i) the Merger Agreement and the transactions contemplated thereby (including the Offer
and the Merger) and (ii) the Tender and Support Agreements and the transactions contemplated thereby; 
 WHEREAS, Section 26 of the
Agreement provides that for so long as the Rights are then redeemable, the Company may in its sole and absolute discretion, and the Rights Agent shall, if the Company so directs, supplement or amend any provision of the Agreement in any respect
without the approval of any holders of Rights; 
 WHEREAS, the Rights are currently redeemable; and 
 WHEREAS, pursuant to the Resolutions, the board of directors of the Company has unanimously determined that an amendment to the Agreement as set forth
herein is necessary and desirable in connection with the Merger Agreement, the Tender and Support Agreements, and the transactions contemplated by the Merger Agreement (including the Offer and the Merger) and the Tender and Support Agreements, and
the Company and the Rights Agent desire to evidence such amendment in writing. 

 NOW, THEREFORE, in accordance with Section 26 of the Agreement, and in consideration of the
foregoing and the mutual agreements herein set forth and for other good and valuable consideration, the parties hereby agree as follows: 
 1.
Amendment of the Agreement 
 a. Section 1 of the Agreement is hereby amended and supplemented to add the following definitions in
the appropriate locations: 
 “Merger” shall mean the “Merger” as such term is defined in the Merger Agreement.

 “Merger Agreement” shall mean the Agreement and Plan of Merger, dated as of January 8, 2009, by and among the Company,
Parent and Purchaser, as such may be amended from time to time. 
 “Offer” shall mean the “Offer” as such term is
defined in the Merger Agreement. 
 “Parent” shall mean Abbott Laboratories, an Illinois corporation, or any of its subsidiaries,
including Purchaser. 
 “Purchaser” shall mean Rainforest Acquisition Inc., a newly formed Delaware corporation and wholly owned
subsidiary of Parent. 
 “Tender and Support Agreements” shall mean (i) the Tender and Support Agreements, dated as of
January 11, 2009, by and among the Parent and ValueAct Capital Master Fund, L.P, ValueAct Capital Master Fund III, L.P, and Mason Morfit, as such may be amended from time to time; and (ii) the Tender and Support Agreements, dated as of
January 11, 2009, by and among the Parent and James V. Mazzo. 
 “Top-Up Option” shall mean the “Top-Up Option” as
such term is defined in the Merger Agreement. 
 b. The definition of “Acquiring Person” in Section 1 of the Agreement is
hereby amended and supplemented by adding the following sentence at the end thereof: 
 “Notwithstanding anything in this Agreement to
the contrary, none of Parent, Purchaser, or their respective Affiliates or Associates shall be, or shall be deemed to be, an Acquiring Person for purposes of this Agreement by virtue of one or more of (i) the approval, execution, or delivery of
the Merger Agreement or the Tender and Support Agreements, (ii) the public or other announcement of the Merger Agreement, the Top-Up Option, the Tender and Support Agreements, or any transaction contemplated by or arising in connection with the
Merger Agreement (including the Offer and the Merger) or the Tender and Support Agreements, or (iii) the consummation of the Offer, the Merger, or any transaction contemplated by or arising in connection with the Merger 

 
Agreement (including the Top-Up Option) or the Tender and Support Agreements (each such event and any combination of such events, an “Exempt
Event”)” 
 c. The definition of “Shares Acquisition Date” in Section 1 of the Agreement is hereby amended and
supplemented by adding the following proviso immediately following the words “shall become aware of the existence of an Acquiring Person”: 
 “; PROVIDED, HOWEVER, that notwithstanding anything in this Agreement to the contrary, a Shares Acquisition Date has not occurred and shall not be deemed to have occurred as the result of an Exempt Event.”

 d. The definition of “Trigger Event” in Section 1 of the Agreement is hereby amended and supplemented by adding the
following proviso immediately following the words “any Person becoming an Acquiring Person”: 
 “; PROVIDED, HOWEVER, that
notwithstanding anything in this Agreement to the contrary, a Trigger Event has not occurred and shall not be deemed to have occurred as the result of an Exempt Event.” 
 e. Section 3.1 of the Agreement is hereby amended and supplemented by adding the following proviso immediately following the words “the earlier
of (i) and (ii) being herein referred to as the “Distribution Date”: 
 “; PROVIDED, HOWEVER, that notwithstanding
anything in this Agreement to the contrary, a Distribution Date has not occurred and shall not be deemed to have occurred as the result of an Exempt Event.” 
 f. Section 3 of the Agreement is hereby amended and supplemented to add the following Section 3.4: 
 “3.4 Exempt Events. Nothing in this Agreement shall be construed to give any holder of Rights or any other Person any legal or equitable rights, remedies or claims under this Agreement by virtue of an Exempt Event.” 
 g. Section 7.1 of the Agreement is hereby amended and supplemented to add the following sentence at the end thereof: 
 “Notwithstanding anything herein to the contrary, immediately prior to the Effective Time (as defined in the Merger Agreement), this Agreement shall
terminate and shall have no further force and effect and the Rights shall expire and become null and void, without any payment, liability or obligation on the part of the Company, the Rights Agent or the holders of any Rights. The Company shall give
the Rights Agent prior written notice of the Effective Time.” 
 h. Section 15 of the Agreement is hereby amended and supplemented
to add the following sentence at the end thereof: 
 “Nothing in this Agreement shall be construed to give any registered holder of the
Rights Certificates (or, prior to the Distribution Date, the registered holders of the Common Shares) or any other Person any legal or equitable rights, remedy or claim under this Agreement in connection with any transaction contemplated by the
Merger Agreement, including, without limitation, the grant and/or exercise of the Top-Up Option, the execution of and performance under the Tender and Support Agreements and the making and consummation of the Offer.” 

 2. Governing Law. This Amendment shall be deemed to be a contract made under the laws of the State
of Delaware and for all purposes shall be governed by and construed in accordance with the laws of such State applicable to contracts to be made and performed entirely within such State; provided, however, that all provisions regarding
the rights, duties and obligations of the Rights Agent shall be governed by and construed in accordance with the laws of the State of New York applicable to contracts made and to be performed entirely within such State. 
 3. Execution in Counterparts. This Amendment may be executed in any number of counterparts, each of which shall be an original, and all of which
together shall constitute a single instrument. 
 4. Effectiveness. This Amendment shall be deemed effective as of, and immediately
prior to, the execution and delivery of the Merger Agreement. Except as amended hereby, the Agreement shall remain in full force and effect and shall be otherwise unaffected hereby. If for any reason the Merger Agreement is terminated in accordance
with its terms, then this Amendment shall become null and void and be of no further force and effect and the Agreement shall remain exactly the same as it existed immediately prior to the execution of this Amendment. 
 5. Severability. If any term, provision, covenant or restrictions of this Amendment is held by a court of competent jurisdiction or other
authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall remain in full force and effect and shall in no way be affected, impaired or invalidated; provided,
however, that if such excluded provision shall affect the rights, immunities, duties or obligations of the Rights Agent, the Rights Agent shall be entitled to resign upon one Business Day’s notice to the Company. 
 [Signature Page Follows] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of the day and
year first above written. 
  

			
	ADVANCED MEDICAL OPTICS, INC.
		
	By:	 	 /s/ Aimee S. Weisner

	Name:	 	Aimee S. Weisner
	Title:	 	Executive Vice President, Administration and Secretary
	
	MELLON INVESTOR SERVICES LLC
		
	By:	 	 /s/ Sharon Knepper

	Name:	 	Sharon Knepper
	Title:	 	Vice PresidentTender and Support Agreement

 Exhibit 10.1 
 Tender and Support Agreement 
 January 11, 2009 
 Abbott Laboratories 
 100 Abbott Park Road 
 Abbott Park, Illinois 60064-6400 
 Re: Tender and Support
Agreement 
 Ladies and Gentlemen: 
 Concurrently with the execution and delivery of this letter agreement, Abbott Laboratories, an Illinois corporation (“Parent”), Rainforest Acquisition Inc., a Delaware corporation and a wholly owned subsidiary of
Parent (the “Purchaser”), and Advanced Medical Optics, Inc., a Delaware corporation (the “Company”) are entering into an Agreement and Plan of Merger, dated the date of this letter agreement (the
“Merger Agreement”), providing for, among other things, the Offer (as defined in the Merger Agreement) by the Purchaser for all of the outstanding common stock, par value $0.01 per share, of the Company (“Company
Common Stock”) at a price per share of $22.00, net to the seller in cash (such price or any higher price paid in the Offer, the “Offer Price”), to be followed by a merger of the Purchaser with and into the
Company, with the Company as the surviving corporation (the “Merger”), pursuant to which each share of Company Common Stock then outstanding (other than as specifically provided for to the contrary in the Merger Agreement),
shall be converted into the right to receive an amount in cash without interest equal to the Offer Price pursuant to the terms of the Merger Agreement. Capitalized terms used but not defined in this letter agreement shall have the meanings ascribed
to such terms in the Merger Agreement. 
 Each undersigned stockholder (“Stockholder”) of the Company is the
beneficial owner of Company Common Stock on the date of this letter agreement. 
 Because execution of this letter agreement is a condition
to Parent’s willingness to proceed with the transactions contemplated by the Merger Agreement, Stockholder is entering into this letter agreement to induce Parent to enter into the Merger Agreement and to consummate the transactions
contemplated by the Merger Agreement. 
 The parties hereto agree as follows: 
 1. (i) Stockholder represents and warrants that, as of the date of this letter agreement, Stockholder is the beneficial owner of the shares of Company
Common Stock indicated on Schedule I attached hereto (such shares, together with any New Shares (as defined in Section 8), being referred to herein as the “Shares”), free and clear of all liens, charges, encumbrances,
voting agreements, and commitments of every kind, except for the obligations undertaken by the parties under this letter agreement and as described on Schedule I attached hereto or pursuant to any applicable restrictions on transfer under the
Securities Act. 
 (ii) Stockholder represents and warrants that, except as set forth on Schedule I, as of the date of this letter agreement,
Stockholder does not: (a) own beneficially or of record, or have any right to acquire, any shares of Company Common Stock or any other shares of the capital stock of the Company; (b) have any other interest in shares of Company Common
Stock or any other shares of the capital stock of the Company; or (c) have any voting rights with respect to any other shares of Company Common Stock or any other shares of the capital stock of the Company. 

 (iii) Each of Stockholder, Parent and the Purchaser represents and warrants that such party has all
necessary power and authority to enter into this letter agreement and that this letter agreement is the legal, valid and binding agreement of such party, enforceable against such party in accordance with its terms, except as such enforceability may
be limited by bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or other similar Laws now or hereafter in effect relating to creditors’ rights generally and by general equitable principles (regardless of whether
enforceability is considered in a proceeding in equity or at law). If Stockholder is married and the Shares constitute community property or otherwise are owned or held in a manner that requires spousal or other approval for this letter agreement to
be a legal, valid and binding agreement of Stockholder, this letter agreement has been duly consented to and delivered by such Stockholder’s spouse or the person giving such approval, and is enforceable against such spouse or person in
accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or other similar Laws now or hereafter in effect relating to creditors’ rights generally and by
general equitable principles (regardless of whether enforceability is considered in a proceeding in equity or at law). 
 2. (i) Stockholder
agrees that during the Term (as defined in Section 7) it will not, directly or indirectly, sell or otherwise transfer, or dispose of or grant any interest in any of the Shares or any direct or indirect economic or other interest in those shares
of Company Common Stock or securities convertible into shares of Company Common Stock or any voting rights with respect to any of those shares, or agree to do any of the foregoing (a “Transfer”), other than Transfers thereof:
(a) pursuant to the Offer or the Merger; (b) with Parent’s prior written consent; (c) the transfer of Shares between and among accounts that are solely controlled by Stockholder, if at all times such accounts hold Shares, and
which do not place prohibitions or restrictions on the ability of such Stockholder to perform any of its agreements or obligations hereunder; (d) between ValueAct Capital Master Fund, L.P. and ValueAct Capital Master Fund III, L.P.; or
(e) to any affiliate of the Stockholder who executes a similar letter agreement. As used in this letter agreement, the term “Transfer,” shall also include any pledge, hypothecation, encumbrance, assignment or
constructive sale or other disposition of such security or the record or beneficial ownership thereof, the offer to make a sale, transfer, constructive sale or other disposition, and each agreement, arrangement or understanding whether or not in
writing, to effect any of the foregoing. As used in this letter agreement, the term “constructive sale” means a short sale with respect to such security, entering into or acquiring a derivative contract with respect to such
security, entering into or acquiring a futures or forward contract to deliver such security or entering into any transaction that has substantially the same effect as any of the foregoing. 
 (ii) Stockholder agrees that during the Term it shall use commercially reasonable efforts to take or cause to be taken all actions, and to do or to cause
to be done, and to assist and cooperate with the other parties in doing, all things necessary, proper or advisable to consummate and make effective, in the most expeditious manner practicable, the Offer, the Merger and the transactions contemplated
by this letter agreement. 
 (iii) Stockholder hereby consents to and approves the actions taken by the Company Board in approving the Merger
Agreement, this letter agreement and the transactions contemplated hereby and thereby, including the Merger and the Offer. 
 3. Unless this
letter agreement shall have been terminated in accordance with its terms, Stockholder agrees during the Term to validly tender (and, to the extent applicable, to cause the record owner of the Shares (including Stockholder’s broker) to tender)
all of the Shares by physical delivery of the certificates therefor (to the extent that such Shares are filed in certificated form) or by book-entry delivery (to the extent that such Shares are not in certificated form) pursuant to and in accordance
with the terms of the Offer, not later than five (5) Business Days prior to the Expiration Date of the Offer. Stockholder agrees that once its Shares are tendered, such Stockholder will not withdraw any of the 

  

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Shares from the Offer, unless and until (i) the Offer shall have been terminated in accordance with the terms of the Merger Agreement or (ii) this
letter agreement shall have been terminated in accordance with its terms. 
 4. Stockholder hereby permits Parent and the Purchaser to
publish and disclose in a Tender Offer Statement on Schedule TO with respect to the Offer and the Company to publish and disclose in a Solicitation/Recommendation Statement on Schedule 14D-9, and, if approval of the Company’s stockholders is
required under the Delaware General Corporation Law, any proxy statement relating to the Merger (including, in each case, all documents and schedules filed with the SEC), Stockholder’s identity and the ownership by Stockholder of the Shares and
the nature of Stockholder’s commitments, arrangements and understandings hereunder. Parent, on behalf of itself and the Purchaser, hereby permits Stockholder to disclose in a Schedule 13D (including any amendments or supplements thereto and all
documents and schedules affixed to or referenced therein) pertaining to the Offer filed with the SEC the nature of the commitments, arrangements and understandings of the parties hereunder. Before any such disclosure shall be made by any party, the
disclosing party shall provide the other parties a reasonable opportunity to review and comment on such disclosure. 
 5. Stockholder agrees
that it will not, and will not permit any of its Subsidiaries or subject to Section 16, any of its directors, officers, employees and representatives (collectively, “Representatives”), directly or indirectly, to:
(i) initiate, solicit or knowingly take any action to facilitate or encourage (including without limitation by way of providing information) the submission of any inquiries, proposals or offers or any other efforts or attempts that constitute,
or may reasonably be expected to lead to, an Acquisition Proposal, or engage in any discussions or negotiations with respect thereto, or (ii) enter into any Contract or agreement in principle that is intended or would reasonably be expected to
lead to an Acquisition Proposal or that would reasonably be expected to cause the Company to abandon, terminate or breach its obligations under the Merger Agreement or fail to consummate the transactions contemplated by the Merger Agreement.
Stockholder shall immediately cease and cause to be terminated any solicitation, encouragement, discussion or negotiation with any Persons conducted prior to the execution of this letter agreement with respect to any Acquisition Proposal. From and
after the execution of this letter agreement, Stockholder shall promptly (but no later than 24 hours following such receipt) advise Parent of the receipt, directly or indirectly, of any inquiries or proposals or participation in discussions or
negotiations, relating to a proposal that constitutes or may reasonably be expected to lead to an Acquisition Proposal in the same manner as is required of the Company under the Merger Agreement under similar circumstances. 
 6. (i) Stockholder agrees that, at any meeting of the Company’s stockholders held during the Term, however called, or if action by written consent
of the Company’s stockholders is sought during the Term, Stockholder (in Stockholder’s capacity as such) will, or will cause the holder of record on any applicable record date to: (a) vote (or execute a consent with respect to) the
Shares in favor of the Merger; (b) vote (or execute a consent with respect to) the Shares against any action or agreement that would result in a breach of any covenant, representation or warranty or any other obligation or agreement of the
Company under the Merger Agreement; and (c) vote (or execute a consent with respect to) the Shares against any action or agreement (other than the Merger Agreement or the transactions contemplated by the Merger Agreement) that would, directly
or indirectly, impede, interfere with, delay, postpone or, directly or indirectly, discourage the Offer or the Merger. 
 (ii) Stockholder
hereby irrevocably grants to the extent permitted by applicable Law, and appoints, Parent and any individual designated in writing by Parent, and each of them individually, as Stockholder’s proxy and attorney-in-fact (with full power of
substitution), for and in the name, place and stead of Stockholder, solely to vote the Shares, or grant a consent or approval in respect of the Shares in a manner consistent with this Section 6. Stockholder understands and acknowledges that
Parent is entering into the Merger Agreement in reliance upon Stockholder’s execution and delivery of this letter agreement. Parent and its designees hereby agree not to exercise the proxy for any other purpose. Stockholder hereby 

  

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affirms that the irrevocable proxy set forth in this Section 6(ii) is given in connection with the execution of the Merger Agreement, and that such
irrevocable proxy is given to secure the performance of the duties of Stockholder under this letter agreement. Stockholder hereby further affirms that the irrevocable proxy is coupled with an interest and may under no circumstances be revoked.
Stockholder hereby ratifies and confirms all that such irrevocable proxy may lawfully do or cause to be done by virtue hereof. Such irrevocable proxy is executed and intended to be irrevocable in accordance with the provisions of Section 212(e)
of the Delaware General Corporation Law. The irrevocable proxy granted hereunder shall automatically terminate, without any notice or other action by any Person, upon the earlier of (a) the end of the Term or (b) termination of this letter
agreement in accordance with its terms. 
 7. The term of this letter agreement and the proxy granted hereby (the
“Term”) shall commence on the date hereof and shall terminate on the earliest of (i) the mutual written consent of the parties; (ii) the Effective Time; (iii) the termination of the Merger Agreement in
accordance with its terms; and (iv) the amendment of the Offer or the Merger Agreement to provide for a reduction in the Offer Price or a change in the form of consideration to be paid in the Offer. 
 8. Stockholder agrees that, in the event (a) of any stock dividend, stock split,
recapitalization, reclassification, combination or exchange of shares of capital stock of the Company or any of its Subsidiaries of, or affecting, the Shares, (b) that Stockholder purchases or otherwise acquires beneficial ownership of or an
interest in any shares of capital stock of the Company or any of its Subsidiaries after the execution of this letter agreement (including by conversion) or (c) that Stockholder voluntarily acquires the right to vote or share in the voting of
any shares of capital stock of the Company or any of its Subsidiaries other than the Shares (collectively, “New Shares”), that Stockholder shall deliver promptly (but no later than the second (2nd) Business Day following such acquisition) to Parent written notice of its acquisition of New Shares which notice shall state the number of New Shares so
acquired. Stockholder agrees that any New Shares acquired or purchased during the Term by Stockholder shall be subject to the terms of this letter agreement and shall constitute the Shares of Stockholder to the same extent as if those New Shares
were owned by Stockholder on the date of this letter agreement. In any such case, the warranties and representations set forth in Section 1 of this letter agreement shall be deemed amended accordingly to be made as of the date thereof.

 9. The transactions contemplated by this letter agreement are unique and the parties agree that irreparable damage would occur in the
event that any of the provisions of this letter agreement were not performed in accordance with their specific terms or were otherwise breached. Accordingly, the parties hereto agree that, if for any reason a party hereto shall have failed to
perform its obligations under this letter agreement, then the party hereto seeking to enforce this letter agreement against such nonperforming party under this letter agreement shall be entitled, in addition to all other remedies to which it may be
entitled, to specific performance and injunctive and other equitable relief, and the parties hereto further agree to waive any requirement for the securing or posting of any bond in connection with the obtaining of any such injunctive or other
equitable relief. 
 10. All notices and other communications hereunder shall be in writing and shall be deemed given if delivered personally
(when so delivered), telecopied (when confirmed, unless confirmed on a day that is not a Business Day, in which case notice shall be deemed given on the Business Day following such confirmation) or dispatched by a nationally recognized overnight
courier service (as of the time of delivery as confirmed by such courier service): (a) if to Parent, at such party’s address set forth in Section 8.2 of the Merger Agreement, with a copy to such party’s counsel at such
party’s counsel’s address set forth in Section 8.2 of the Merger Agreement (or, in each case, at such other address for such party (or such party’s counsel) as shall be specified by like notice) and a copy to the Company at its
address set forth in Section 8.2 of the Merger Agreement, with a copy to the Company’s counsel at the Company’s counsel’s address set forth in Section 8.2 of the Merger Agreement (or, in each case, at such other address for
the Company or the Company’s counsel as shall be specified by like notice), or (b) if to Stockholder, at such party’s address set forth on Schedule I hereto, with a copy to such party’s counsel at such party’s 

  

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counsel’s address set forth on Schedule I hereto (or, in each case, at such other address for such party (or such party’s counsel) as shall be
specified by like notice) and a copy to the Company at its address set forth in Section 8.2 of the Merger Agreement, with a copy to the Company’s counsel at the Company’s counsel’s address set forth in Section 8.2 of the
Merger Agreement (or, in each case, at such other address for the Company or the Company’s counsel as shall be specified by like notice). 
 11. This letter agreement shall be governed by, and construed in accordance with, the laws of the State of Delaware, without giving effect to any choice or conflict of laws provision or rule (whether of the State of Delaware or any other
jurisdiction) that would cause the application of the Laws of any jurisdiction other than the State of Delaware. 
 12. Each of the parties
hereto (i) shall submit itself to the exclusive jurisdiction of the Delaware Court of Chancery (and if jurisdiction in the Delaware Court of Chancery shall be unavailable, the Federal court of the United States of America sitting in the State
of Delaware) for the purpose of any action, suit or proceeding (“Action”) arising out of or relating to this letter agreement or any of the transactions contemplated hereby, (ii) irrevocably and unconditionally waives
(and agrees not to plead or claim) any objection to the laying of venue of any Action arising out of or relating to this letter agreement or any of the transactions contemplated hereby in the Delaware Court of Chancery (and if the Delaware Court of
Chancery shall be unavailable, in any Delaware State court or the Federal court of the United States of America sitting in the State of Delaware) or that any such action, suit or proceeding brought in any such court has been brought in an
inconvenient forum, and (iii) shall not bring any Action arising out of or relating to this letter agreement or any of the transactions contemplated hereby in any court other than the Delaware Court of Chancery (and if jurisdiction in the
Delaware Court of Chancery shall be unavailable, the Federal court of the United States of America sitting in the State of Delaware). Each of the parties hereto agrees that a final judgment in any Action shall be conclusive and may be enforced in
other jurisdictions by suit on the judgment or in any other manner provided by law. Each of the parties to this letter agreement irrevocably consents to the service of any summons and complaint and any other process in any Action relating to this
letter agreement, the Offer and the Merger, on such party’s behalf or such party’s property, by the personal delivery of copies of such process to such party. Nothing in this Section 12 shall affect the right of any party to this
letter agreement to serve legal process in any other manner permitted by law. 
 13. This letter agreement shall be binding upon and inure to
the benefit of each of the parties to this letter agreement and their respective successors, including by will or intestate succession. This letter agreement may not be assigned to any other person without the prior written consent of the other
parties to this letter agreement, which consent may be withheld for any reason or for no reason. 
 14. This letter agreement constitutes the
entire agreement among the parties to this letter agreement with respect to the matters covered hereby, and supersedes all prior agreements, understandings or representations among the parties to this letter agreement, written or oral, with respect
to the subject matter of this letter agreement. 
 15. If any term or other provision of this letter agreement is invalid, illegal or
incapable of being enforced by any rule or law, all other conditions and provisions of this letter agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions contemplated hereby is not
affected in any manner materially adverse to any party. Upon such determination that any term or other provisions in invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this letter agreement so
as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the extent possible. 
 16. Nothing in this letter agreement shall be construed to prohibit Stockholder or any of Stockholder’s Representatives who is an officer or member
of the Board of Directors of the Company 

  

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from taking any action in his or her capacity as an officer or member of the Board of Directors of the Company or, subject to the limitations set forth in
the Merger Agreement, from taking any action with respect to any Acquisition Proposal as an officer or member of such Board of Directors. This letter agreement shall apply to Stockholder solely in Stockholder’s capacity as a stockholder of the
Company. 
 17. This letter agreement may not be amended, changed, supplemented or otherwise modified except by an instrument in writing
signed on behalf of Parent, the Purchaser and Stockholder. 
 [Signatures on following page] 
  

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 If you are in agreement that the foregoing correctly states the agreement among us, please sign and
return to each of us an executed counterpart of this letter agreement. This letter agreement shall become effective among the parties specified herein, upon the undersigned’s receipt of executed counterparts of this letter agreement from each
of such parties. 
  

			
	Very truly yours,
	
	VALUEACT CAPITAL MASTER FUND, L.P.
		
	BY:	 	VA PARTNERS I, LLC
		
	By:	 	 /s/ VA Partners I, LLC

	Name:	 	George F. Hamel, Jr.
	Title:	 	Chief Operating Officer
	
	VALUEACT CAPITAL MASTER FUND III, L.P.
		
	BY:	 	VA PARTNERS III, LLC
		
	By:	 	 /s/ VA Partners III, LLC

	Name:	 	George F. Hamel, Jr.
	Title:	 	Chief Operating Officer
	
	 /s/ G. Mason Morfit

	G. Mason Morfit

  

			
	Agreed the date first above written.
	
	ABBOTT LABORATORIES
		
	By:	 	 /s/ Thomas C. Freyman

	Name:	 	Thomas C. Freyman
	Title:	 	 Executive Vice President, Finance
 & Chief Financial
Officer

	
	RAINFOREST ACQUISITION INC.
		
	By:	 	 /s/ Thomas C. Freyman

	Name:	 	Thomas C. Freyman
	Title:	 	President

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