Document:

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                                                                   Exhibit 10.60

                             COLLABORATION AGREEMENT

         This Collaboration Agreement, dated as of December 22, 2003 (the
"Agreement") is entered into by and among University of Massachusetts, a public
institution of higher education of the Commonwealth of Massachusetts having an
address at 365 Plantation Street, Suite 130, Worcester, MA 01605 ("UMass"),
Advanced BioScience Laboratories, Inc., a Delaware corporation having its
principal place of business at 5510 Nicholson Lane, Kensington, MD 20895 ("ABL")
and CytRx Corporation, a Delaware corporation having an address at 11726 San
Vicente Boulevard, Suite 650, Los Angeles, California 90049 ("CytRx") with
reference to the following facts:

         A.       In December 2002, UMass filed a provisional patent
application, U.S. Patent Application Serial Number 60/430,732 (the "03-24 Patent
Filing") with the United States Patent and Trademark Office covering a
foundational HIV vaccine technology invention referred to by UMass as UMMC 03-24
(the "03-24 Technology").

         B.       In May 2003, UMass granted an exclusive worldwide license to
the 03-24 Patent Filing and 03-24 Technology to CytRx pursuant to an Exclusive
License Agreement, dated as of April 15, 2003 by and between UMass and CytRx
(the "03-24 License Agreement" and as amended and restated pursuant to this
Agreement, the "Amended and Restated 03-24 License Agreement").

         C.       In June 2000, ABL was awarded a $15 million contract from the
National Institutes of Health (NIAID Prime Contract N01-05394) (the "NIH Prime
Contract") in connection with the development of a DNA-based HIV vaccine and on
June 26, 2000, ABL entered into a subcontract with UMass (Subcontract No.
00454B-UMM-NAID-N01-A1-05395) (the "UMass Subcontract") in connection with the
development of an HIV vaccine using the 03-24 Technology and the 03-111
Technology and currently being developed by UMass and ABL under the NIH Prime
Contract and the UMass Subcontract (the "HIV Vaccine"). The HIV Vaccine will
include for purposes of this Agreement the foregoing vaccine product
notwithstanding the expiration or early termination of either the NIH Prime
Contract or the UMass Subcontract.

         D.       ABL anticipates filing in January 2004 an investigational new
drug application (as defined in the United States Federal Food, Drug and
Cosmetic Act of 1938, as amended from time to time (the "Act")) with the United
States Food and Drug Administration ("FDA") for a Phase I clinical trial of the
HIV Vaccine (the "IND") and expects to commence this Phase I trial (the "Phase I
Trial") within 30 to 60 days following the IND being cleared by the FDA.

         E.       In September 2003, ABL filed a provisional patent application,
U. S. Patent Application Serial Number 60/503,907 (the "03-111 Patent Filing")
covering an HIV protein boost technology invention referred to by UMass and ABL
as UMMC 03-111 (the "03-111 Technology").

         F.       On December 3, 2003, ABL and UMass made a joint filing with
the United States Patent and Trademark Office of a combined patent application
(the "Joint Patent

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Filing") for the 03-24 Technology and the 03-111 Technology that included all of
the claims of the 03-24 Patent Filing and 03-111 Patent Filing and other claims
relating to the 03-24 Technology and 03-111 Technology. Both a U.S.
non-provisional patent application and a PCT application designating all
countries were filed simultaneously. Both the non-provisional and the PCT
applications claim priority to the 03-24 Patent Filing.

         G.       In conjunction with the Joint Patent Filing, ABL, CytRx and
UMass entered into an Agreement dated as of December 3, 2003 (the "Patent Filing
Agreement"), regarding the development and commercialization of the HIV Vaccine
and providing for the framework for negotiation of this Agreement as a
definitive agreement covering such development and commercialization.

         H.       ABL, CytRx and UMass now wish to enter into this Agreement
regarding the development and commercialization of the HIV Vaccine in accordance
with the Patent Filing Agreement.

         NOW, THEREFORE, in consideration of the mutual representations and
covenants contained herein, the parties hereby agree as follows:

         1.       Definitions.

                  1.1      "ABL Licensed Product" means any product that cannot
be developed, manufactured, used, or sold without (i) infringing one or more
claims under the ABL Related Technology, or (ii) using some portion of the ABL
Related Technology.

                  1.2      "ABL Related Technology" means any additional
technologies outside of the 03-24 Technology and the 03-111 Technology that
satisfy all of the following: (i) are now or subsequently owned or licensed to
ABL, including any technologies that may be acquired by ABL pursuant to its
option for an exclusive license under Section 9 of the UMass Subcontract, (ii)
result from work done by UMass under the UMass Subcontract for a DNA-based HIV
vaccine with protein boost, and (iii) are deemed necessary or advantageous by
CytRx for the development or commercialization of the HIV Vaccine.

                  1.3      "ABL Sublicense Agreement" means the sublicense
agreement between CytRx and ABL described in Section 14.4.

                  1.4      "ABL Royalty Period" means the partial calendar
quarter commencing on the date on which the first ABL Licensed Product is sold
or used and every complete or partial calendar quarter thereafter during which
(i) this Agreement remains in effect and each country where ABL's patent rights
to the ABL Related Technology have not expired or been abandoned or revoked and
(ii) CytRx, its Affiliates and/or sublicensees are selling ABL Licensed Product.

                  1.5      "Affiliate" means any legal entity (such as a
corporation, partnership, or limited liability company) that is controlled by or
controls the entity in question. For the purposes of this definition, the term
"control" means (i) beneficial ownership of at least 50% of the voting
securities of a corporation or other business organization with voting
securities

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or (ii) a 50% or greater interest in the net assets or profits of a partnership
or other business organization without voting securities.

                  1.6      "Collaborative Press Release" means the joint ABL and
CytRx press release announcing the signing of this Agreement.

                  1.7      "Good Manufacturing Practices" means the then-current
good manufacturing practices required by the FDA, as set forth in the Act and
the regulations promulgated thereunder, for the manufacture and testing of
pharmaceutical materials, and comparable laws or regulations applicable to the
manufacture and testing of pharmaceutical materials in jurisdictions outside the
United States.

                  1.8      "Phase I Completion" means the completion of the
                           Phase I Trial.

                  1.9      "Manufacturing Agreement" means the commercial
manufacturing agreement that may be entered into by and between ABL or its
Affiliate and CytRx or its Affiliate pursuant to the terms of Section 7.2.

                  1.10     "Net Sales" means the gross amount received based on
billed or invoiced sales by the applicable party or its Affiliates or
sublicensees of ABL Licensed Products or New Vaccine products (as applicable,
the "Product"), less the following: (i) customary trade, quantity, or cash
discounts and commissions to non-affiliated brokers or agents to the extent
actually allowed and taken; (ii) amounts repaid or credited by reason of
rejection or return; (iii) to the extent separately stated on purchase orders,
invoices, or other documents of sale, any taxes or other governmental charges
levied on the production, sale, transportation, delivery, or use of a Product
which is paid by or on behalf of the applicable party or its Affiliates or
sublicensees; (iv) outbound transportation costs prepaid or allowed and costs of
insurance in transit; and (v) sales at or below the fully burdened cost of
manufacturing Product, solely for research or clinical testing of such Product
or for indigent or similar public support or compassionate use programs. In any
transfers of Products between the applicable party or its Affiliates or
sublicensees and its Affiliate or sublicensee, Net Sales shall be calculated
based on the final sale of the Product to an independent third party. In the
event that the applicable party or its Affiliates or sublicensees receives
non-monetary consideration for any Products, Net Sales shall be calculated based
on the fair market value of such consideration. In the event that CytRx or ABL
or their Affiliates or sublicensees use or dispose of a Product in the provision
of a commercial service, the Product shall be considered sold and the Net Sales
shall be calculated based on the sales price of the Product to an independent
third party during the same period or, in the absence of such sales, on the fair
market value of the Product as determined by CytRx and ABL in good faith.

                  1.11     "New Vaccine" means any HIV vaccine other than the
HIV Vaccine.

                  1.12     "New Vaccine Party" means a party to this Agreement
seeking to commercialize a New Vaccine.

                  1.13     "UMass Related Technology" means any additional
technologies outside of the 03-24 Technology and 03-111 Technology that (i) are
owned or licensed to UMass, and have not been acquired by or licensed to ABL
pursuant to ABL's option for an

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exclusive license under Section 9 of the UMass Subcontract, (ii) result from
work done by UMass under the UMass Subcontract, and (iii) are deemed necessary
or advantageous to CytRx for the development or commercialization of the HIV
Vaccine.

                  1.14     "Vaccine Assignment" means the irrevocable assignment
by ABL to CytRx of all of ABL's rights, title and interest in and to the HIV
Vaccine, including without limitation ABL's right to develop, make, have made,
use, offer for sale, market and sell the HIV Vaccine worldwide. Notwithstanding
the foregoing, the Vaccine Assignment will be subject to and subordinate to any
rights that the Government of the United States may have to the HIV Vaccine by
virtue of the NIH Prime Contract funding.

                  1.15     "91-03 License" means the exclusive, worldwide
license for the 91-03 Technology.

                  1.16     "91-03 Technology" means the technology referred to
by UMass as UMMC 91-03.

         2.       Joint Patent Filing. The Joint Patent Filing shall be
prosecuted by Fish & Richardson (or another patent firm retained by UMass and
reasonably acceptable to ABL and CytRx). The Joint Patent Filing shall also be
filed in such foreign jurisdictions as shall be requested by either ABL or
CytRx. The costs of preparing, submitting and prosecuting the Joint Patent
Filing (limited to the actual fees of the appropriate patent offices and
expenses of patent counsel for UMass) shall be borne by CytRx, except that ABL
shall bear all of the legal fees and other expenses of preparing, submitting and
prosecuting the Joint Patent Filing in any foreign jurisdiction that it requests
be made. In the event any patent office divides or takes other similar action
with respect to the Joint Patent Filing, each of the parties to this Agreement
shall have the same rights and obligations and access to the 03-24 Technology
and 03-111 Technology under this Agreement that it would have had in the absence
of any such division or other similar action.

         UMass shall decide all patent prosecution matters in consultation with
ABL and CytRx. ABL and CytRx shall receive copies of all material correspondence
from any patent office within a reasonable amount of time and shall be provided
with copies of all proposed material filings or other submissions to any patent
office so as to afford ABL and CytRx with a reasonable opportunity to comment
upon such proposed filing or submission.

         3.       IND Filing. ABL shall use its commercially reasonable best
efforts to file the IND by no later than January 31, 2004, to obtain clearance
of the IND by the FDA, to commence the Phase I Trial within 30 days following
FDA clearance of the IND and to complete the Phase I Trial within 18 months from
the commencement of the trial. ABL shall notify UMass and CytRx in writing
within two business days following the IND filing and the commencement of the
Phase I Trial and shall promptly provide UMass and CytRx with all material
correspondence received from or delivered to the FDA or the institution at which
the Phase I Trial will be conducted relating to the IND or Phase I Trial.

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         4.       Phase I Trial.

                  4.1      Conduct of Phase I Trial. As set forth in the UMass
Subcontract, UMass will be responsible for carrying out the Phase I Trial,
including the preparation of all elements required for conducting a human Phase
I clinical trial, the recruiting of patients, the conduct and management of the
Phase I Trial and assistance with the collation of data and preparation of
required reports summarizing the data generated by the Phase I Trial for
submission to the FDA upon the Phase I Completion. Subject to applicable
confidentiality obligations, UMass shall consult with ABL and CytRx with respect
to the status and conduct of the Phase I Trial and the submission of any
required reports to the FDA in connection with the Phase I Trial. ABL and UMass
shall provide each of the parties to this Agreement with copies of all
correspondence delivered to or received from the FDA during and after the Phase
I Trial relating to such trial, subject to applicable federal laws and
regulations covering confidentiality as applied either under the NIH Prime
Contract or FDA regulations. In the event all of the required patients to
complete the Phase I Trial have not been enrolled within 30 days following the
IND being cleared by the FDA, CytRx will be permitted to direct the patient
recruitment efforts in consultation with UMass, to the extent CytRx's activities
are consistent with applicable FDA and other federal regulations. ABL, UMass and
CytRx shall agree on a schedule for each stage of the Phase I Trial and the
submission of the data generated by the Phase I Trial that is consistent with
the final submission of such data to the FDA within 18 months of FDA clearance
of the IND. Should performance of the Phase I Trial fall more than 30 days
behind this schedule, CytRx shall be entitled, subject to the terms of the NIH
Prime Contract and the UMass Subcontract, in consultation with UMass to direct
the work necessary to complete that stage of the Phase I Trial. CytRx shall be
entitled to be reimbursed out of the NIH Prime Contract or the UMass Subcontract
to the maximum extent permitted under the terms of those contracts for its
out-of-pocket expenses incurred in performing the recruitment or other work
described in this Section 4.1.

                  4.2      Expenses of Phase I Trial. Except as specifically set
forth in Section 4.1 and this Section 4.2, CytRx shall bear no responsibility
for carrying out any aspect of the Phase I Trial or incur any costs or
liabilities in connection therewith. In the event completion of the Phase I
Trial requires expenditures not covered under the UMass Subcontract, such
expenditures shall be funded, to the maximum extent possible, under the
remaining funds from the NIH Prime Contract. In the event the remaining funds
from the NIH Prime Contract are insufficient to cover all of the costs to
complete the Phase I Trial, CytRx may elect to pay for all of those expenses
(after all of the available funds from the NIH Prime Contract have first been
applied). CytRx shall be entitled to offset all of the foregoing excess expenses
that it pays against any milestone payments (other than the first milestone
payments to ABL due upon the IND filing) that it becomes obligated to pay under
the Amended and Restated 03-24 License Agreement.

                  4.3      Maintenance of NIH Prime Contract. ABL and UMass
shall use their commercially reasonable efforts to maintain in effect the NIH
Prime Contract and UMass Subcontract, which are currently anticipated to
continue through completion of the Phase I Trial. In the event of the early
cancellation of the NIH Prime Contract for any reason, UMass agrees to continue
to conduct the Phase I Trial as contemplated by the UMass Subcontract, provided
that it receives compensation for its services comparable to that which was
provided

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for by the UMass Subcontract. Subject to complying with this Section 4.3, ABL
shall have no liability to UMass and CytRx due to such cancellation.

                  4.4      Insurance; Indemnification. ABL shall maintain
clinical trial insurance for the Phase I Trial in an amount and form in
accordance with the NIH Prime Contract and UMass Subcontract and shall provide
CytRx with evidence of such insurance coverage. ABL or, to the extent allowable
by law, UMass, as the case may be, shall indemnify and hold harmless CytRx and
its officers, directors, employees, agents and affiliates from and against all
liabilities and expenses (including reasonable attorneys fees) resulting
directly from ABL's or UMass's negligence or intentional misconduct in the
conduct of the Phase I Trial.

         5.       Assignment of HIV Vaccine.

                  5.1      Assignment. The Vaccine Assignment shall occur
immediately following the Phase I Completion. ABL hereby represents that to the
best of its knowledge no other party has any rights to, liens upon or interest
in the HIV Vaccine, except to the extent of the Joint Patent Filing, any
government retained rights which may arise by operation of federal laws
governing products and intellectual property developed under government
contracts and certain intellectual property rights of Antigenics which the HIV
Vaccine may infringe if the vaccine is commercialized.

                  5.2      Sole Sponsorship. Following the Vaccine Assignment
and provided CytRx elects to undertake further clinical trials after the Phase I
Trial, CytRx will be the sole sponsor of the HIV Vaccine for FDA purposes. ABL
and UMass will cooperate with CytRx, at CytRx's expense in making all necessary
FDA and foreign healthcare regulatory agency filings to reflect the Vaccine
Assignment and will provide CytRx with copies of all filings and correspondence
with the FDA and any foreign healthcare regulatory agencies made in connection
with the HIV Vaccine.

         6.       Subsequent Clinical Development of HIV Vaccine.

                  6.1      Conduct of Clinical Development. Following the Phase
I Completion, CytRx will be responsible at its own expense for carrying out and
completing all subsequent clinical trials that are required to obtain FDA
marketing approval for the HIV Vaccine and marketing approval for any other
countries. The parties acknowledge that CytRx may seek to obtain additional
governmental or private grants, including grants from the National Institutes of
Health, to support the clinical development of the HIV Vaccine, and UMass agrees
to provide reasonable assistance to CytRx in filing for and obtaining such
grants. CytRx shall advise ABL and UMass regarding all material matters relating
to the development of the HIV Vaccine, but all decisions concerning the
development of the HIV Vaccine shall be made by CytRx in its sole discretion.

                  6.2      Insurance; Indemnification. CytRx shall maintain
clinical trial insurance for all subsequent clinical trials of the HIV Vaccine
in an amount and form customary for clinical trials of this type and shall
provide UMass and ABL with evidence of such insurance coverage. CytRx shall
indemnify and hold harmless UMass and ABL for any liabilities arising from the
HIV Vaccine in accordance with Section 3.2 of the Amended and Restated 03-24
License Agreement.

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         7.       Manufacture of HIV Vaccine.

                  7.1      ABL Supplies and Assistance. ABL shall provide all
Phase I clinical trial supplies for the HIV Vaccine in accordance with the NIH
Prime Contract. Following the completion of any Phase I trials for the HIV
Vaccine, ABL shall provide reasonable assistance to CytRx in providing relevant
information to a third party manufacturer for clinical supplies of the HIV
Vaccine for any remaining clinical trials, including consulting with such
manufacturer and providing such manufacturer with access to drug master files or
other FDA filings in connection with the manufacturing process. CytRx shall
reimburse ABL for its time and out-of-pocket expenses incurred in providing the
foregoing assistance at the same rate that it would charge the government.

                  7.2      Manufacturing Agreement. Within 30 days of being
notified by CytRx that CytRx has received an "approvable BLA" letter from the
FDA for the HIV Vaccine or an equivalent notification from any foreign
healthcare regulatory agency, ABL or its Affiliates shall have the option to
acquire the commercial manufacturing rights for the HIV Vaccine for the United
States or any other applicable territory, provided that ABL or its Affiliate
then has the required regulatory approvals and manufacturing capacity. The terms
of such manufacturing rights shall be set forth in the Manufacturing Agreement,
which will be negotiated in good faith by ABL and CytRx and entered into within
60 days of the date ABL is notified by CytRx that CytRx has received the
"approvable BLA" letter, and will include such economic and other terms as are
customarily contained in an agreement of that type, including without limitation
representations and warranties of ABL or its Affiliate that it shall ensure that
the HIV Vaccine is manufactured in accordance with the then-current Good
Manufacturing Practices, as specified by the applicable laws and regulations in
the territory, and the relevant specifications as determined in writing by the
parties.

                  7.3      Supply of HIV Vaccine. The Manufacturing Agreement
shall require ABL or its Affiliate to use its best efforts, consistent with Good
Manufacturing Practices, to conduct all manufacturing of the HIV Vaccine so that
ABL can supply HIV Vaccines in sufficient quantities to meet all purchase orders
for HIV Vaccine in the territory covered by the Manufacturing Agreement.

                  7.4      Alternate Manufacturer. The Manufacturing Agreement
shall permit CytRx to utilize an alternate manufacturer in the event ABL or its
Affiliate is unable or unwilling to meet all of the supply requirements for the
HIV Vaccine for any reason for more than an agreed to period of time. In that
event, ABL or its Affiliate shall provide a royalty-free license to the
alternate manufacturer for any manufacturing processes required to produce the
HIV Vaccine.

         8.       Marketing of HIV Vaccine. CytRx will be solely responsible, at
its own expense, for the commercial marketing of the HIV Vaccine. All decisions
concerning the countries in which the HIV Vaccine shall be marketed, the methods
of marketing and all other matters concerning the marketing of the HIV Vaccine
shall be made by CytRx in its sole discretion.

         9.       CytRx Licensee or Strategic Partner. CytRx shall have the
right to enter into sublicense, strategic alliance or other agreements with one
or more third parties pursuant to

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which the sublicensee or strategic partner may be responsible (either jointly
with CytRx or alone) for the development, commercial manufacture (subject to
ABL's option set forth in Section 7) or marketing of the HIV Vaccine; provided,
however, that nothing contained in this Section 9 shall alter the obligations
and undertakings of CytRx under the Amended and Restated 03-24 License
Agreement.

         10.      Amendment to 03-24 License Agreement. Concurrently with the
execution of this Agreement, the parties shall enter into the Amended and
Restated 03-24 License Agreement in the form attached hereto as Exhibit B. ABL
and UMass agree that the inclusion of the 03-111 Technology into the Amended and
Restated 03-24 License Agreement shall occur without further compensation to
UMass or ABL, except for the payments specified in the Amended and Restated
03-24 License Agreement, and at no additional cost to CytRx.

         11.      Compensation Payable to ABL. UMass, CytRx and ABL agree that
as payment in full for ABL's Vaccine Assignment to CytRx and its other
agreements under this Agreement, ABL shall be entitled to receive from CytRx the
following sums, as and if applicable:

                  (i)      {***} of all payments due to UMass under Sections
4.3, 4.5, 4.6, 4.7 and 4.8 of the Amended and Restated 03-24 License Agreement;

                  (ii)     subject to the offset provisions of Section 4.2,
{***} of any sums due to UMass under the following milestone payments listed
under Section 4.4 of the Amended and Restated 03-24 License Agreement: for
"entry into Phase II clinical trial"; for "entry into Phase III clinical trial";
upon "filing for market approval in any country besides the United States"; for
"commencement of product marketing in the United States"; and for "first market
approval for the first three European countries"; and

                  (iii)    {***} of the milestone payment listed under Section
4.4 of the Amended and Restated 03-24 License Agreement, for "filing of IND or
equivalent for each product";

                  (iv)     {***} shares of CytRx common stock (100% of which
shall be retained by ABL) concurrently with the payment set forth in clause
(iii) above, with such shares to have customary piggyback rights, which shall
entitle ABL, among other things, to have a registration statement filed on CytRx
covering such shares with the applicable federal and state securities
commissions within 120 days of the IND filing and to use its commercially
reasonable efforts to complete the registration within 60 days after the filing
of the registration statement; provided, however, that UMass hereby agrees that
all amounts payable to it by CytRx under the terms of Sections 4.3 thru 4.8 of
the original 03-24 License Agreement shall be modified in the Amended and
Restated 03-24 License Agreement by reducing those originally provided for
amounts by {***} of the corresponding amounts payable by CytRx to ABL under
clauses (i) through (iii) above.

         12.      License to ABL Related Technologies.

                  12.1     Grant. Subject to the terms of this Agreement, ABL
hereby grants to CytRx and its Affiliates the right to acquire at their sole
discretion a non-exclusive,

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worldwide, royalty-bearing license to the ABL Related Technology. CytRx shall
have the right to grant sublicenses of its rights obtained under this Section
12.1.

                  12.2     Royalty. In consideration of the rights granted to
CytRx under Section 12.1, CytRx shall pay to ABL during the applicable ABL
Royalty Period a royalty on sales of the ABL License Products by CytRx or its
Affiliates in an amount that shall be negotiated in good faith by ABL and CytRx
or its Affiliates at the time they acquire such license rights.

                  12.3     Other Terms. The license granted pursuant to Section
12.1 shall have such other customary terms as shall be agreed to by ABL and
CytRx.

         13.      Right of First Negotiation to UMass Related Technologies.

                  13.1     Grant. UMass hereby grants to CytRx and its
Affiliates a right of first negotiation to obtain a worldwide, royalty-bearing
license to all of UMass's exclusive or non-exclusive rights to the UMass Related
Technology. If CytRx acquires any license pursuant to the foregoing right, that
license shall include sublicense rights for CytRx or UMass and CytRx shall agree
on the provision of related non-exclusive licenses from UMass to any strategic
partner or licensee of CytRx.

                  13.2     Royalty and Other Terms. The royalty rate for any
license obtained by CytRx pursuant to Section 13.1 shall be negotiated in good
faith by CytRx and UMass. The non-economic terms of such license shall be
substantially the same as those set forth in the 03-24 License Agreement.

                  13.3     Prior ABL Rights. UMass may not grant any rights to
UMass Related Technology to CytRx unless UMass has first offered such rights to
ABL in accordance with the right of first refusal provisions of the UMass
Subcontract.

         14.      Competing Vaccines.

                  14.1     New Vaccine. Subject to the terms of this Agreement,
ABL and CytRx each shall be permitted to develop and commercialize New Vaccines
that may compete with the HIV Vaccine; provided, however, that if the New
Vaccine infringes any of the claims set forth in the Joint Patent Filing but for
the existing ownership rights of the New Vaccine Party in the Joint Patent
Filing, the New Vaccine Party shall pay to the other party {***} of the Net
Sales by the New Vaccine Party of the New Vaccine; provided, however, that the
percentage of the Net Sales to be paid by the New Vaccine Party to the other
party shall be increased to {***} in the event the HIV Vaccine has received FDA
or similar foreign agency approval and is at such time being marketed for use in
humans.

                  14.2     Sublicenses. In the event the New Vaccine Party
sublicenses the New Vaccine to a sublicensee, the New Vaccine Party shall pay to
the other party {***} of any royalties, fees and milestone payments or other
income received by the New Vaccine Party from the sublicensee; provided,
however, that in the event the HIV Vaccine has been commercialized and will be
in competition with the New Vaccine, the percentage of any royalties, fees and
milestone payments or other income received by the New Vaccine Party from the
sublicensee shall be increased to {***}.

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                  14.3     Treatment of Payments under Amended and Restated
03-24 License Agreement. Any payments received by CytRx from ABL pursuant to
Sections 14.1 and 14.2 above shall be treated as "Sublicense Income" pursuant to
the Amended and Restated 03-24 License Agreement; provided, however, that the
Amended and Restated 03-24 License Agreement shall provide that out of
"Sublicense Income" received by CytRx from ABL under Sections 14.1 and 14.2
above, CytRx shall pay an amount to ABL equal to {***} of such Sublicense Income
and an amount to UMass equal to {***} of such Sublicense Income.

                  14.4     ABL Sublicense. Subject to the other provisions of
this Section 14, ABL shall have the right to continue using the 03-111
Technology and to use the 03-24 Technology, provided that such use is solely for
the purpose of developing and commercializing HIV vaccines other than the HIV
Vaccine. Concurrently with the signing of the Amended and Restated 03-24 License
Agreement pursuant to Section 10, CytRx shall grant ABL a non-exclusive license
to the 03-111 Technology and 03-24 Technology in the form attached as Exhibit C
hereto (the "ABL Sublicense Agreement"). Payments made by ABL to CytRx under the
ABL Sublicense Agreement shall be subject to the payment requirements of
Sections 14.1 and 14.2 and payment by ABL of those amounts shall satisfy the
payment obligations of ABL to CytRx under Sections 14.1 and 14.2.

         15.      Option for UMMC 91-03. UMass hereby grants CytRx an option for
a fee of {***} (with such fee creditable to the cost of the exclusive license)
to acquire for its sole use and benefit the 91-03 License. The 91-03 License
will cover all potential uses of the 91-03 Technology and will be on such
economic terms as shall be agreed to by UMass and CytRx, but shall be no less
attractive to CytRx than those set forth in UMass's licensing term sheet
delivered to CytRx on November 25, 2003. The other terms and conditions of the
91-03 License shall be substantially similar to those set forth in the 03-24
License Agreement. The foregoing option shall be exercised by CytRx at its sole
discretion at any time prior to April 1, 2004.

         16.      Representations and Warranties.

                  16.1     Authority to Enter Into Agreement. Each of the
parties hereto, and the persons signing this Agreement on their behalf,
represent and warrant that each is a legal entity with full right and authority
in law and in fact to enter into and perform this Agreement, and that such
execution will not conflict or result in a breach of any other agreement to
which such party is a party or by which it is bound.

                  16.2     ABL Other Technology. ABL hereby represents and
warrants that it does not as of the date of this Agreement own or have any
rights, title or interest to or in any other technology or patent that would be
infringed by the development or commercialization of the HIV Vaccine.

                  16.3     NIH Prime Contract. ABL hereby represents to the best
of its knowledge that it is compliance with all of the terms of the NIH Prime
Contract, that it has not been notified by the NIH of any non-compliance or
default by ABL under the NIH Prime Contract and has no reason to believe that it
will be unable to continue to comply with all of the terms of the NIH Prime
Contract for the rest of the term of that contract.

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         17.      Miscellaneous.

                  17.1     Term of Agreement. This Agreement shall continue in
force until terminated in writing by all of the parties hereto.

                  17.2     Disclosure.

                           (a)      Upon the signing of this Agreement, the
parties promptly shall jointly issue the Collaborative Press Release announcing
such signing, with the text of such press release to contain a summary
description of the material terms of the this Agreement (but not the specific
royalty rates or other similar financial terms) and to be reasonably acceptable
to all of the parties. If the IND is filed after the issuance of the
Collaborative Press Release, the parties shall promptly jointly issue a press
release announcing such filing, with the text of such press release to be
reasonably acceptable to all of the parties. Upon the commencement of the Phase
I Trial, the parties shall promptly jointly issue a press release announcing
such filing, with the text of such press release to be reasonably acceptable to
all of the parties. No party to this Agreement shall make any public disclosure
concerning this Agreement, the IND, the Phase I Trial or any other matter
concerning the development of the HIV Vaccine without the consent of the other
parties to this Agreement, which shall not be unreasonably withheld. All press
releases shall be consistent with the requirements of the NIH Prime Contract and
any other applicable federal laws governing disclosure and confidentiality
(including HHSAR 352.224-70) and shall be acceptable to the Contracting Officer
of the NIH Prime Contract or other representative of the NIAID.

                           (b)      Notwithstanding anything to the contrary in
Section 17.2(a), CytRx shall have the right to disclose factual information
related to this Agreement, the IND, the Phase I Trial and any other matter
related to the development or commercialization of the HIV Vaccine to research
collaborators, business entities in any and all filings and disclosures
necessary or required by the FDA and/or by any other governmental agency in
connection with the development, licensing, sublicensing and approval of any
products relating to the HIV Vaccine or as otherwise required by law to be
disclosed by CytRx as determined by CytRx's counsel but only so long as all such
disclosures are consistent with the requirements of the NIH Prime Contract and
any other applicable federal laws governing disclosure and confidentiality
(including HHSAR 352.224-70). Prior to the Vaccine Assignment, CytRx shall
provide ABL and UMass with copies of any material new information disclosures of
this type prior to making such disclosures.

                           (c)      Except as required by law or to perform the
terms of this Agreement, no party hereto shall use the name, symbols or marks of
any other party in connection with any product, promotion or advertising,
including in connection with the development and marketing of the HIV Vaccine,
without the prior written consent of such other party, which shall not be
unreasonably withheld..

                  17.3     Confidential Information.

                           (a)      Any non-disclosure agreements between any of
the parties to this Agreement shall continue in full force and effect. However,
each party to this Agreement shall be permitted to use or disclose any of the
confidential information supplied to it prior to

                                       11
<PAGE>

or after the date of this Agreement, but solely for regulatory and manufacturing
purposes as specified in this Agreement and provided that the party making such
disclosure takes reasonable steps to limit the number of persons receiving the
confidential information and to maintain the confidentiality of the disclosed
information (where public disclosure is not required). Notwithstanding the
foregoing, no such disclosure shall be made unless the parties have determined
that the disclosure does not violate any confidentiality provisions governing
the NIH Prime Contract (including HHSAR 352.224-70) or that the Contracting
Officer has consented to such disclosure.

                           (b)      The parties to this Agreement acknowledge
their respective obligations under this Agreement to maintain the security and
confidentiality of individually identifiable patient health information. The
parties agree to abide by the terms of any research authorization and informed
consent signed by participants in any clinical trials and research related to
the development and commercialization of the HIV Vaccine, and to comply with
applicable federal and state health information confidentiality laws and
regulations, including as applicable, the Standards for Privacy of Individually
Identifiable Health Information published at Title 45 of the United States Code
of Federal Regulations parts 160 and 164.

                  17.4     Governing Law. This Agreement shall be governed by
and construed in accordance with the laws of the State of California (United
States of America) without reference to any conflict of law provisions thereof.
The parties hereby submit to the exclusive jurisdiction of, and venue in, the
state and federal courts located in Los Angeles, California.

                  17.5     Severability. If a court of competent jurisdiction
determines that any provision of this Agreement is invalid or unenforceable,
then the invalidity or the unenforceability of that provision shall not affect
the validity or enforceability of any other provision of this Agreement, and all
other provisions shall remain in full force and effect. If any of the provisions
of this Agreement is held to be excessively broad, it shall be reformed and
construed by limiting and reducing it so as to be enforceable to the maximum
extent permitted by law.

                  17.6     Parties' Reliance Upon Counsel. All the parties have
each consulted and relied upon their respective attorneys' legal advice and
their own judgment and choice in deciding to enter into this Agreement. The
parties to this Agreement have read it completely and their attorneys have
explained it to them. The undersigned parties voluntarily accept the terms of
this Agreement and fully understand those terms.

                  17.7     Assignment; Binding Effect. Subject to Section 9, no
party may assign or transfer this Agreement or any of its rights or obligations
hereunder, without the express prior written consent of the other parties.
However, nothing in this Section 17.7 shall prohibit any party from assigning
this Agreement to a successor in interest by merger, assignment, purchase or
otherwise of substantially all of the assets and business of that party or any
division or subsidiary of CytRx within which the HIV Vaccine is being developed
or commercialized. This Agreement shall inure to the benefit of and be binding
upon each party hereto, its successors and permitted assigns.

                  17.8     Independent Contractors. In the performance of the
respective obligations and responsibilities hereunder, each of the parties shall
be deemed to be and shall

                                       12
<PAGE>

be an independent contractor. No party is authorized or empowered to act as
agent for the other for any purpose and shall not, on behalf of, the other enter
into any contract, warranty or representation as to any matter. No party hereto
shall be bound by the acts or conduct of any other party.

                  17.9     Notices. Any notice required or permitted herein
shall be in writing and shall be deemed given as of the date it is (a) delivered
by hand, (b) received by registered or certified mail, postage prepaid, return
receipt requested, (c) delivered to a party by a nationally-recognized overnight
courier service such as FedEx or Airborne, with evidence of delivery, or (d)
received by facsimile and addressed to the party to receive such notice at the
address set forth below, or such other address as is subsequently specified in
writing:

If to CytRx:                              If to UMass:

CytRx Corporation                         Office of Technology Management
Attention: Steven A. Kriegsman            University of Massachusetts Medical
Chief Executive Officer                     School
11726 San Vicente Blvd., Suite 650        Attention: Chester A. Bisbee
Los Angeles, CA 90049                     Acting Director
Tel: (310) 826-5449                       365 Plantation Street, Suite 130
Fax: (310) 826-5529                       Worcester, MA 01605
                                          Tel: (508) 856-1626
                                          Fax: (508) 856-1482
If to ABL:

Advanced BioScience Laboratories, Inc.
Attention: Johannes Burlin
President and CEO
5510 Nicholson Lane
Kensington, Maryland 20895
Tel: (301 ) 881-5600
Fax: (301 ) 984-3608

                  17.10    Entire Agreement; Transaction Costs. This Agreement,
together with the Amended and Restated 03-24 License Agreement, the ABL
Sublicense Agreement and the Confidentiality and Non-Disclosure Agreement, dated
November 21, 2003, between ABL and CytRx (the "ABL/CytRx NDA"), constitutes the
entire agreement between the parties with regard to the subject matter of this
Agreement. It supersedes all other prior understandings, transactions and
communications, whether written or oral, between the parties with respect to the
matters referred to herein. In the event of any direct conflict between the
terms of this Agreement and the Amended and Restated 03-24 License Agreement or
the ABL/CytRx NDA, the terms of this Agreement shall prevail; except that in the
event of a dispute relating to the Amended and Restated 03-24 License Agreement
in which UMass is a party, the governing law provisions of Section 10.9 of the
Amended and Restated 03-24 License Agreement shall control. Each party shall
bear its own fees and expenses in connection with negotiating this Agreement and
the Definitive Collaborative Agreement.

                                       13
<PAGE>

                  17.11    Amendments. No modification of this Agreement, nor
any future representation, promise or agreement in connection with the subject
matter of this Agreement shall be binding on the parties unless made in writing
and signed on their respective behalf by their respective authorized
representatives.

                  17.12    Waivers. The waiver by one or several parties of any
right hereunder, or of any failure to perform or breach by one party hereunder,
shall not be deemed a waiver of any other right hereunder or of any other breach
or failure by the other parties hereunder whether of a similar nature or
otherwise.

         In witness whereof, the parties have caused this Agreement to be
signed, in multiple identical originals, by their duly authorized
representatives, with effect as of the date first written above.

                                        UNIVERSITY OF MASSACHUSETTS

                                        By: /s/ CHESTER A. BISBEE
                                           -------------------------------------

                                        Its:      Acting Director, Office of
                                                  Technology Management
                                              ----------------------------------
                                        Date: December 22, 2003
                                              ----------------------------------

                                        CYTRX CORPORATION

                                        By: /s/ STEVEN A. KRIEGSMAN
                                           ------------------------------------
                                                  Steven A. Kriegsman
                                        Its:      Chief Executive Officer

                                        Date:
                                             ---------------------------------

                                        ADVANCED BIOSCIENCE LABORATORIES, INC.

                                        By: /s/ JOHANNES BURLIN
                                           -----------------------------------
                                                  Johannes Burlin
                                        Its:      President and CEO

                                        Date: December 22, 2003
                                             --------------------------------

                                       14
<PAGE>

                                    EXHIBIT B

              Form of Amended and Restated 03-24 License Agreement

                FILED SEPARATELY IN CYTRX CORPORATION'S FORM 10-K
                      FOR THE YEAR ENDED DECEMBER 31, 2003

                                    EXHIBIT C

                             Form of ABL Sublicense

                FILED SEPARATELY IN CYTRX CORPORATION'S FORM 10-K
                      FOR THE YEAR ENDED DECEMBER 31, 2003<PAGE>

                                                                   Exhibit 10.61

                              SUBLICENSE AGREEMENT

         THIS SUBLICENSE AGREEMENT is made the 22nd day of December 2003 BETWEEN
CytRx Corporation, a Delaware corporation having an address of 11726 San Vicente
Boulevard, Suite 650, Los Angeles, California 90049 (referred to as "CYTRX"),
and Advanced BioScience Laboratories, Inc., a Delaware corporation having its
principal place of business at 5510 Nicholson Lane, Kensington, Maryland 20895
(referred to as "ABL").

                                    RECITALS

         WHEREAS, in June 2000, ABL was awarded a $15 million contract from the
National Institutes of Health (NIAID Prime Contract N01-05394) (the "NIH Prime
Contract") and on June 26, 2000, ABL entered into a subcontract No.
00454B-UMM-NAID-N01-A1-05395 with University of Massachusetts Medical School
("UMass") (the "UMass Subcontract") in connection with the development of a
DNA-based HIV vaccine that incorporates the 03-24 Technology and the 03-111
Technology (as further described below) (the "HIV Vaccine").

         WHEREAS, in December 2002, UMass filed a provisional patent
application, U.S. Patent Application Serial Number 60/430,732 covering invention
disclosure number UMMC 03-24 entitled Primary and Polyvalent HIV-1 Envelope
Glycoprotein DNA Vaccines (the "03-24 Technology");

         WHEREAS, in September 2003, ABL filed a provisional patent application,
U.S. Patent Application Serial Number 60/503,907 covering an HIV protein boost
technology invention referred to by UMass and ABL as UMMC 03-111 (the "03-111
Technology");

         WHEREAS, on December 3, 2003, ABL and UMass made a joint filing with
the United States Patent and Trademark Office of a combined patent application
for the 03-24 Technology and the 03-111 Technology that included all of the
claims of the 03-24 Patent Filing and 03-111 Patent Filing, with both a U.S.
non-provisional patent application and a PCT application designating all
countries being filed simultaneously and with both the non-provisional and the
PCT applications (the "Joint Patent Filing");

         WHEREAS, on December 22, 2003 UMass and ABL granted CYTRX a worldwide
exclusive license to the Joint Patent Filing, which includes the 03-24
Technology and 03-111 Technology (the "Amended and Restated Exclusive License
Agreement");

         WHEREAS, in conjunction with the Joint Patent Filing, ABL, CYTRX and
UMass entered into an Agreement, dated as of December 22, 2003, regarding the
development and commercialization of the HIV Vaccine and other rights (the
"Definitive Collaborative Agreement");

         WHEREAS, pursuant to the Definitive Collaborative Agreement and the
Amended and Restated Exclusive License Agreement CYTRX hereby grants ABL
sublicense rights to the Patent Rights granted to CYTRX in the Amended and
Restated Exclusive License

<PAGE>

Agreement under said rights to make, have made, use, manufacture and sell
products using the Joint Patent Filing technology under the following conditions
(the "Sublicense Agreement");

         IT IS HEREBY AGREED AS FOLLOWS:

         1.       Definitions. For this Sublicense Agreement, and solely for
this purpose, the terms set forth below shall be defined as follows. All terms
not defined herein shall have the meaning set forth in the Amended and Restated
Exclusive License Agreement.

                  1.1      "Affiliate(s)" shall mean any corporation, firm,
partnership or other entity which directly or indirectly owns or is owned by or
is under common ownership with a party to this Sublicense Agreement to the
extent of at least fifty-one percent (51%) of the equity having the power to
vote on or direct the affairs of the entity.

                  1.2      "Amended and Restated Exclusive License Agreement"
shall mean the exclusive license agreement entered into between UMass, CytRx and
ABL related to the Joint Patent Filing and as defined in the Whereas provision
above.

                  1.3      "Biological Materials" shall mean certain tangible
biological materials that are necessary for the effective exercise of the Patent
Rights, which materials may be described on Exhibit A, as well as tangible
materials that are routinely produced through use of the original materials,
including, for example, any progeny derived from a cell line, monoclonal
antibodies produced by hybridoma cells, DNA or RNA replicated from isolated DNA
or RNA, recombinant proteins produced through use of isolated DNA or RNA, and
substances routinely purified from a source material included in the original
materials (such as recombinant proteins isolated from a cell extract or
supernatant by non-proprietary affinity purification methods).

                  1.4      "CPR" shall mean the CPR Institute for Dispute
Resolution.

                  1.5      "Effective Date" shall mean January 1, 2004.

                  1.6      "Field" shall mean all HIV vaccines.

                  1.7      "Licensed Product" shall mean any HIV vaccine product
other than the HIV Vaccine that cannot be developed, manufactured, used, or sold
without infringing one or more Valid Claim(s) under the Patent Rights (without
taking into account any co-ownership rights of ABL or its Affiliates in the
Patent Rights).

                  1.8      "Net Sales" shall mean the gross amount billed or
invoiced on sales of Licensed Products by ABL and its Affiliates to third
parties, less (i) 9% as an allowance to reflect each of the following
irrespective of the amounts actually incurred for these items: the (a) customary
trade, quantity, or cash discounts and commissions to non-affiliated brokers or
agents to the extent actually allowed and taken; and (b) amounts repaid or
credited by reason of rejection or return and (ii) 5% of the amount of Net Sales
after the foregoing 9% allowance, with the 5% allowance to reflect each of the
following irrespective of the amounts actually incurred for these items: (a) to
the extent separately stated on

                                       2
<PAGE>

purchase orders, invoices, or other documents of sale, any taxes or other
governmental charges levied on the production, sale, transportation, delivery,
or use of a Licensed Product which is paid by or on behalf of ABL; (b) outbound
transportation costs prepaid or allowed and costs of insurance in transit; and
(c) allowance for bad debt that is customary and reasonable for the industry and
in accordance with generally accepted accounting principles. Notwithstanding
anything to the contrary in this Section 1.7, Net Sales does not include sales
of Licensed Products at or below the fully burdened cost of manufacturing solely
for research or clinical testing or for indigent or similar public support or
compassionate use programs.

         In any transfers of Licensed Products between ABL and an Affiliate, Net
Sales shall be calculated based on the final sale of the Licensed Product to an
independent third party. In the event that ABL or an Affiliate receives
non-monetary consideration for any Licensed Products, Net Sales shall be
calculated based on the fair market value of such consideration.

         In the case of Combination Products, Net Sales means the gross amount
billed or invoiced on sales of the Combination Product less the deductions set
forth above, multiplied by a proration factor that is determined as follows:

                           (i)      If all components of the Combination Product
were sold separately during the same or immediately preceding Royalty Period,
the proration factor shall be determined by the formula [A / (A+B)], where A is
the aggregate gross sales price of all Licensed Product components during such
period when sold separately from the other essential functional components, and
B is the aggregate gross sales price of the other essential functional
components during such period when sold separately from the Licensed Product
Components; or

                           (ii)     If all components of the Combination Product
were not sold separately during the same or immediately preceding Royalty
Period, the proration factor shall be determined by the formula [C / (C+D)],
where C is the aggregate fully absorbed cost of the Licensed Product components
during the prior Royalty Period and D is the aggregate fully absorbed cost of
the other essential functional components during the prior Royalty Period, with
such costs being determined in accordance with generally accepted accounting
principles.

                  1.9      "New Vaccine" shall mean any HIV vaccine other than
the HIV Vaccine.

                  1.10     "Notice Date" shall mean the date on which an
affected party notifies the other parties of any dispute arising out of or
relating to this Sublicense Agreement.

                  1.11     "Patent Rights" shall mean the U.S. patent
applications listed on Exhibit A, and any divisional, continuation, or
continuation-in-part of such patent applications to the extent the claims are
directed to subject matter specifically described therein, as well as any patent
issued thereon and any reissue or reexamination of such patent, and any foreign
counterparts to such patents and patent applications.

                  1.12     "Parties" shall mean ABL and CytRx.

                                       3
<PAGE>

                  1.13     "Royalty Period" means any calendar quarter
commencing on January 1, April 1, July 1 or October 1 during which a Licensed
Product is sold or used and every complete or partial calendar quarter
thereafter during which this Agreement remains in effect.

                  1.14     "Sublicense" shall mean a nonexclusive worldwide
sublicense with right to sublicense to third parties under CYTRX's commercial
rights in the Patent Rights to make, have made, use, sell and have sold Licensed
Products other than the HIV Vaccine in the Field within the Territory.

                  1.15     "Territory" shall mean the world.

                  1.16     "Valid Claim" shall mean on a country by country
basis any issued or pending claim of a Patent Right which has not expired or
been abandoned or allowed to expire or been declared invalid by a court of
competent jurisdiction in any unappealed or unappealable decision.

         2.       Sublicense. Subject to the Patent Rights granted to CYTRX
under the Amended and Restated Exclusive License Agreement and the terms of this
Sublicense Agreement, CYTRX grants ABL and its Affiliates the Sublicense. This
Sublicense shall be effective as of January 1, 2004 and shall remain in force
until expiration of the last to expire of the Patent Rights, unless terminated
earlier in accordance with Article 6. Any sublicensee of ABL shall specifically
agree to be bound by the terms of this Sublicense Agreement.

         3.       Payments and Reporting.

                  3.1      Payments. In consideration for the rights granted
hereunder, ABL shall pay to CYTRX the following amounts:

                           (a)      Royalties. ABL shall pay to CYTRX on sales
of Licensed Products made by ABL and its Affiliates from the Effective Date, (1)
royalties of {***} of the Net Sales or (2) if CYTRX has commercial sales of the
HIV Vaccine or any New Vaccine competing with the Licensed Products in the
marketplace, the royalties shall be {***} of the Net Sales. For any royalties,
license fees and milestone payments paid by a third party to ABL under any
sublicense rights granted by ABL, ABL shall pay to CYTRX {***} of those
royalties, license fees and milestone payments except if CYTRX has commercial
sales of the HIV Vaccine or any New Vaccine competing with the Licensed Products
in the marketplace, the payment to be made to CYTRX by ABL under any such
sublicense granted to a third party shall be {***} of royalties, license fees
and milestone payments paid to ABL.

         The royalties shall be paid by ABL on a quarterly basis within thirty
(30) days of the end of each calendar quarter on sales made during such quarter.
Any withholding taxes which ABL shall be required by law to withhold on
remittance of the royalties payments shall be deducted from royalties paid to
CYTRX and paid by ABL as required by applicable law and reported by ABL to
CYTRX. Upon CYTRX's written request, ABL shall furnish CYTRX with copies of
official receipts for such taxes.

                                       4
<PAGE>

                           (b)      Royalty Reduction. If CYTRX grants
additional sublicenses to third parties pursuant to this Sublicense Agreement
(and as permitted by the Amended and Restated Exclusive Licensed Agreement) for
vaccines other than the HIV Vaccine, CYTRX shall notify ABL of any lower royalty
rate and any accompanying payments or other consideration, and the royalties
rates set forth in Section 3.1(a) shall be adjusted, if necessary, so as not to
exceed the royalty rates and other accompanying payments or other consideration
charged any other sublicensee of the Patent Rights during the term of the
non-exclusive sublicense rights granted herein.

                  3.2      Reporting. Together with each royalty payment due
under Section 3.1, ABL shall submit to CYTRX on a quarterly basis a written
statement indicating, on a country-by-country basis, only for those countries
where the Patent Rights are in force or are still pending, (i) the actual sales
volume of all Licensed Products, (ii) the actual gross sales and Net Sales of
3.2(i), and (iii) the amount of royalties, calculated as above, payable thereon
to CYTRX. For this purpose, ABL shall maintain appropriate books of account and
records of all sales of Licensed Products and the Net Sales thereof, for a
period of three (3) years after each royalties payment. At CYTRX's request and
expense, ABL shall make such books of account and records available for
inspection during normal business hours by independent public accountants, who
are appointed by CYTRX for the purpose of verification of ABL's statements
referred to above and are acceptable to ABL. CYTRX agrees to require such
accountants to keep all information obtained during the inspection as strictly
confidential and to only provide CYTRX with such information which is necessary
to verify ABL's statements. The accountant shall report to CYTRX only the amount
of royalties due in each period and any discrepancy with payments made during
such period. In the event of an underpayment that is in excess of the greater of
(i) $5,000 or (ii) 10% of the royalty payment for that period, ABL shall bear
the full cost of the CYTRX audit.

                  3.3      Payments. All payments shall be made in U.S dollars.
Monetary conversions from the currency of a foreign country into U.S. dollars
shall be made at the average exchange rate in force on the last business day of
the period to which the payments relate as reported by The Wall Street Journal
(New York Edition), or on another basis mutually agreed upon by both Parties in
writing.

         4.       Warranties and Liability.

                  4.1      CYTRX's Patent Rights. As of the Effective Date,
CYTRX represents and warrants that: (a) CYTRX has the right to grant the
sublicense granted by it hereunder; and (b) CYTRX has not received any written
communication or challenge by any third party to the legality, validity,
enforceability, use, or ownership of the whole or any part of the Patents
Rights.

                  4.2      CYTRX warrants and represents that it has an
exclusive license to all of the Patent Rights, with the right to grant
sublicenses thereto upon the approval of UMass, and further warrants and
represents that it has the full power and authority to enter into this
Sublicense Agreement and to carry out its obligations herein.

                                       5
<PAGE>

                  4.3      EXCEPT AS PROVIDED IN SECTIONS 4.1 AND 4.2 ABOVE,
CYTRX MAKES NO WARRANTIES OR REPRESENTATIONS WHATSOEVER, WHETHER EXPRESS OR
IMPLIED, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTY OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR THAT THE MANUFACTURE, USE
OR SALE OF LICENSED PRODUCTS BY ABL OR ANY OF ITS AFFILIATES WILL NOT CONSTITUTE
AN INFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF ANY THIRD PARTY.

                  4.4      Without limiting the generality of the foregoing, the
Parties agree that ABL shall indemnify CYTRX (including the officers, directors,
employees, agents, consultants and other representatives of CYTRX) from any and
all damages, losses, costs, or other consequences which CYTRX may incur as a
direct result of any claim by a third party (including, without limitation, any
customer or employee of ABL) resulting from or relating to the development,
manufacture, use or sale of Licensed Products by ABL or its Affiliates; provided
that such indemnification shall not apply to any damages, losses, costs or other
consequences that are directly attributable to the negligent activities or
intentional misconduct of CYTRX.

                  4.5      Infringement of CYTRX's Patent Rights by Third
Parties.

                           (a)      Should ABL become aware of any infringement
or alleged infringement of any of the Patent Rights, ABL shall promptly notify
CYTRX in writing of the name and address of the alleged infringer and of the
alleged acts of infringement and provide any available evidence of the alleged
acts of infringement.

                           (b)      CYTRX shall not be obligated to prosecute
against any third party any suit for infringement of the aforesaid Patent
Rights.

                           (c)      If, at any time during this Sublicense
Agreement, the Patent Rights, in whole, shall be declared invalid in an
unappealed or unappealable decision by a court of competent jurisdiction, this
Sublicense Agreement shall automatically terminate. In such event, ABL shall not
have to pay any royalties to CYTRX.

                           (d)      In the event that CYTRX or UMass under
Section 6.5(d) of the Amended and Restated Exclusive License Agreement chooses
to prosecute any third party for infringement of the Patent Rights or defends
the validity of the Patent Rights against any alleged infringer, ABL shall
render reasonable assistance to CYTRX or UMass, at the reasonable expense of
CYTRX or UMass. Any recovery obtained in an action under this Subsection shall
be distributed as among CYTRX, ABL and UMass according to clauses (i) through
(iii) of Section 6.5(b) of the Amended and Restated Exclusive License Agreement.

                           (e)      In the event that CYTRX and UMass choose not
to prosecute any third party for infringement of the Patent Rights or not to
defend the validity of the Patent Rights against any alleged infringer, ABL
shall have the right to prosecute such third party for infringement of the
Patent Rights or to defend the validity of the Patent Rights

                                       6
<PAGE>

against any alleged infringer and one hundred percent (100%) of all costs
incurred by ABL in such pursuit may be credited by ABL against the royalties
payable after such date to CYTRX hereunder, provided that in no event shall such
royalty payments be reduced by more than fifty percent (50%) in any Royalty
Period. CYTRX shall render all reasonable assistance to ABL, at the reasonable
expense of ABL. Any proceeds recovered shall be applied firstly for the payment
of any royalties to CYTRX against which ABL has deducted amounts under this
Section 4.5(e) and then any remaining proceeds shall be distributed as follows:
(i) each party shall be reimbursed for any expenses incurred in the action
(including the amount of any royalty payments withheld from CYTRX as described
below), (ii) as to ordinary damages, ABL shall receive an amount equal to its
lost profits or a reasonable royalty on the infringing sales (whichever measure
of damages the court shall have applied), less a reasonable approximation of the
royalties that ABL would have paid to CYTRX if ABL had sold the infringing
products and services rather than the infringer, and (iii) as to special or
punitive damages, the parties shall share any award fifty percent (50%) to ABL
and fifty percent (50%) to CYTRX.

         5.       Marketing.

                  5.1      ABL undertakes to use its reasonable efforts to
develop, obtain regulatory approval for and market Licensed Products.

                  5.2      ABL shall not make any use of the name of CYTRX in
connection with the use, manufacture or sale of Licensed Products by ABL and in
any advertising, promotional or sales literature, without the prior written
consent of CYTRX.

                  5.3      ABL shall be responsible for the compliance of
Licensed Products sold by it hereunder with all relevant applicable laws and
regulations. Without limiting the foregoing, all Licensed Products sold by ABL
hereunder shall be labeled with such legends and statements as may be required
by applicable laws or regulations. To the extent commercially feasible and
consistent with prevailing business practices, ABL shall mark all Licensed
Products with the number of each issued patent under the Patent Rights that
applies to such Licensed Product.

                  5.4      In the event an unlicensed third party markets in any
country a Licensed Product which infringes a claim of an issued Patent Rights in
such country, and CYTRX does not bring an infringement action against such third
party or license such third party within ninety (90) days of a written request
from ABL to take action, ABL and CYTRX shall meet and discuss whether such
infringement has an adverse impact on ABL's sales of Licensed Products in such
country and, if so, negotiate in good faith an adjustment to the terms of this
Sublicense Agreement, provided that ABL acknowledges that it is only receiving a
non-exclusive license under this Sublicense Agreement and that any adjustment to
the terms of this Sublicense Agreement shall take into account that the Parties
did not intend that ABL receive, and ABL does not hold, an exclusive sublicense
of any Patent Rights.

                                       7
<PAGE>

         6.       Duration and Termination.

                  6.1      This Sublicense Agreement shall commence on the
Effective Date and shall continue until expiration of the last to expire of the
Patent Rights, unless terminated earlier in accordance with this Article 6.

                  6.2      The obligations of ABL to pay royalties in each
country shall end on a country-by-country basis upon the expiration,
invalidation, withdrawal or abandonment of the last remaining Patent Rights
covering the manufacture, use or sale of Licensed Products in such country.

                  6.3      Notwithstanding anything in this Article to the
contrary, a Party hereto shall have the right, by notice in writing, to
terminate this Sublicense Agreement (i) in the event that the other Party is in
default or breach of any material covenant, undertaking or obligation to be
performed by that Party hereunder, and such default or breach is not corrected
or cured within thirty (30) days after written notice thereof has been given by
the non-defaulting Party; or (ii) in the event that the other Party shall enter
into any arrangement or composition with its creditors or enter or be put into
voluntary or compulsory liquidation (except for the purpose of any
reorganization reasonably acceptable to the other Party), or have its business
enjoined or ordered into receivership by executive or judicial authorities.

                  6.4      Any termination under this Article shall be without
prejudice to the rights of either Party against the other then accruing or
otherwise accrued under this Sublicense Agreement.

                  6.5      Termination of this Sublicense Agreement shall
terminate all outstanding obligations and liabilities between ABL and CYTRX
arising from this Sublicense Agreement except those provided for in Articles 4,
6, 7 and 10.

         7.       Confidentiality.

                  7.1      During the term of this Sublicense Agreement and for
a period of five (5) years thereafter, ABL and CYTRX shall treat all
confidential information received from the other under this Sublicense Agreement
(including information pursuant to Section 3.2) as the exclusive property of the
other Party and agrees not to disclose to any third Party or use any such
information, except as permitted hereunder, without first obtaining the other
Party's written consent. Each Party further agrees to take all practicable steps
to ensure that any such information shall not be used by its directors,
officers, employees or agents, except on like terms of confidentiality as
aforesaid, and that it shall be kept fully private and confidential by them.

                  7.2      The above provision of confidentiality and non-use
shall not apply to that part of such information which a Party is clearly able
to demonstrate:

                           (a)      was rightfully in its possession without
restriction on disclosure or use prior to receipt from the other; or

                                       8
<PAGE>

                           (b)      was in the public domain at the time of
receipt from the other; or

                           (c)      became part of the public domain through no
default of the Party receiving such information, its directors, officers or
employees; or

                           (d)      was lawfully received without restriction on
disclosure or use from some third Party having a right of further disclosure; or

                           (e)      is required to be disclosed by law or
applicable government regulations; or

                           (f)      is independently developed by employees or
representatives of a Party who have had no access to or the benefit of any
disclosure hereunder.

         8.       Notices. Any notice required or permitted to be given
hereunder shall be sent in writing by registered or certified airmail, postage
prepaid, return receipt requested, or by fax, air courier or hand delivery,
addressed to the Party to whom it is to be given, as follows:

              If to CYTRX:               CytRx Corporation
                                         11726 San Vicente Boulevard, Suite 650
                                         Los Angeles, California 90049
                                         Fax: (310) 826-5529
                                         Attention: Steven A. Kriegsman
                                         Invoices to: Steven A. Kriegsman

              If to ABL:                 Advanced BioScience Laboratories, Inc.
                                         5510 Nicholson Lane
                                         Kensington, Maryland 20895
                                         U.S.A.
                                         Fax: (301) 981-3608
                                         Attention: President & CEO
                                         With copy to: General Counsel

or to such other address or addresses as may from time to time be given in
writing by either Party to the other pursuant to the terms hereof.

         9.       Assignment. This Sublicense Agreement shall not be assigned by
either Party without the prior written consent of the other Party, except to any
of their Affiliates, any of the Parties' respective successors in business, or
any of the Parties' Affiliates' respective successors in business (including in
connection with a merger or sale of all or substantially all of the assets of
the entity or of a business division of the entity). In the event of any such
transfer, the transferee shall assume and agree to be bound by the provisions of
this Sublicense Agreement.

                                       9
<PAGE>

         10.      Miscellaneous.

                  10.1     Force Majeure. Any delays in or failures of
performance by either Party under this Sublicense Agreement shall not be
considered a breach of this Sublicense Agreement if and to the extent caused by
occurrences beyond the reasonable control of the Party affected, including, but
not limited to: acts of god; acts, regulations or laws of any government
(including, without limitation, import and export regulations); strikes or other
concerted acts of workers; fires; floods; explosions; riots; wars; rebellion and
sabotage; and any time for performance hereunder shall be extended by the actual
time of delay caused by such occurrence. Each Party shall promptly give notice
to the other of the start and stop should it be so affected by any of the
above-mentioned occurrences and shall provide a reasonable estimate of its
expected duration.

                  10.2     Entire Agreement. This Sublicense Agreement
constitutes the entire understanding between the Parties with respect to the
subject matter hereof, and supersedes and replaces all prior agreements,
understandings, writings and discussions between the Parties relating to said
subject matter. ABL expressly agrees to be bound by the terms of the Amended and
Restated Exclusive License Agreement.

                  10.3     Amendments: Waivers. This Sublicense Agreement may be
amended and any of its terms or conditions may be waived only by a written
instrument executed by both Parties, or, in the case of a waiver, by the Party
waiving compliance. The failure of either Party at any time to require
performance of any provision hereof shall in no manner affect its rights at a
later time to enforce the same. No waiver by either Party of any condition or
term in any instance shall be construed as a further or continuing waiver of
such condition or term or of another condition or term.

                  10.4     Severability. If any provision of this Sublicense
Agreement is or becomes or is deemed invalid, illegal, or unenforceable in any
jurisdiction, then the Parties shall agree upon and add a substitute provision
which shall be intended to provide a legal and enforceable clause with economic
and business purposes similar to the original provision.

                  10.5     Successors and Assigns. This Sublicense Agreement
shall be binding upon and inure to the benefit of and be enforceable by the
Parties hereto and their respective successors and permitted assigns.

                  10.6     Law of the Agreement and Dispute Resolution.

                           (a)      Applicable Law. This Sublicense Agreement
shall be governed by and construed in accordance with the laws of the State of
Massachusetts, without regard to the conflicts of law principles thereof. The
parties hereby submit to the exclusive jurisdiction of, and venue in, the state
and federal courts located in Los Angeles, California.

                           (b)      Negotiation. In the event of any dispute
arising out of or relating to this Sublicense Agreement, the affected party
shall notify the other parties, and the parties shall attempt in good faith to
resolve the matter within ten (10) days after the

                                       10
<PAGE>

Notice Date. Any disputes not resolved by good faith discussions shall be
referred to senior executives of each party, who shall meet at a mutually
acceptable time and location within thirty (30) days after the Notice Date and
attempt to negotiate a settlement.

                           (c)      Mediation. If the matter remains unresolved
within sixty (60) days after the Notice Date, or if the senior executives fail
to meet within thirty (30) days after the Notice Date, either party may initiate
mediation upon written notice to the other party, whereupon both parties shall
be obligated to engage in a mediation proceeding in Los Angeles, California
under the then current CPR Model Procedure for Mediation of Business Disputes,
except that specific provisions of this Section shall override inconsistent
provisions of the CPR Model Procedure. The mediator will be selected from the
CPR Panels of Neutrals. If the parties cannot agree upon the selection of a
mediator within ninety (90) days after the Notice Date, then upon the request of
either party, the CPR shall appoint the mediator. The parties shall attempt to
resolve the dispute through mediation until one of the following occurs: (i) the
parties reach a written settlement; (ii) the mediator notifies the parties in
writing that they have reached an impasse; (iii) the parties agree in writing
that they have reached an impasse; or (iv) the parties have not reached a
settlement within one hundred and twenty (120) days after the Notice Date.

                           (d)      Trial Without Jury. If the parties fail to
resolve the dispute through mediation, or if neither party elects to initiate
mediation, each party shall have the right to pursue any other remedies legally
available to resolve the dispute, provided, however, that the parties expressly
waive any right to a jury trial in any legal proceeding under this Section.

         IN WITNESS WHEREOF, the Parties hereto have caused this Sublicense
Agreement to be executed by their duly authorized officers on the date and year
first above written.

ADVANCED BIOSCIENCE LABORATORIES, INC.    CYTRX CORPORATION

/s/ JOHANNES BURLIN                       /s/ STEVEN A. KRIEGSMAN
--------------------------------------    --------------------------------------
By:    Johannes Burlin                    By:
                                             -----------------------------------
Title: President & CEO                    Title:
                                                --------------------------------

Exhibits

Exhibit A - Patent Rights

                                       11
<PAGE>

                                    EXHIBIT A

                              List of Patent Rights

United States Provisional Patent Application filed December 3, 2002 serial
number 60/430,732 entitled " Polyvalent, Primary HIV-1 Envelope Glycoprotein DNA
Vaccine.

United States Provisional Patent Application filed in September 2003, serial
     number 60/503/907 entitled "Polyvalent DNA and Protein Vaccines."

United States Utility Patent Application filed December 3, 2003 and its foreign
     counterparts referred to by the parties as the Joint Patent Filing.

[NO BIOLOGICAL MATERIALS AS OF THE EFFECTIVE DATE]

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