Document:

exv10w14

 

Exhibit 10.14

 

LOAN AND SECURITY AGREEMENT

ALEXZA MOLECULAR DELIVERY CORPORATION

 

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TABLE OF CONTENTS

	 	 	 	 	 	 	 
	 	 	 	 	Page	 
	1	 	ACCOUNTING AND OTHER TERMS
	 	 	4	 
	 	 	 
	 	 	 	 
	2	 	LOAN AND TERMS OF PAYMENT
	 	 	4	 
	 	 	2.1
     Promise to Pay
	 	 	4	 
	 	 	2.2      Interest Rate, Payments
	 	 	5	 
	 	 	2.3      Fees
	 	 	6	 
	 	 	 
	 	 	 	 
	3	 	CONDITIONS OF LOANS
	 	 	6	 
	 	 	3.1      Conditions Precedent to Initial Credit Extension
	 	 	6	 
	 	 	3.2      Conditions Precedent to all Credit Extensions
	 	 	6	 
	 	 	 
	 	 	 	 
	4	 	CREATION OF SECURITY INTEREST
	 	 	6	 
	 	 	4.1      Grant of Security Interest
	 	 	6	 
	 	 	4.2      Authorization of File
	 	 	6	 
	 	 	 
	 	 	 	 
	5	 	REPRESENTATIONS AND WARRANTIES
	 	 	7	 
	 	 	5.1      Due Organization and Authorization
	 	 	7	 
	 	 	5.2      Collateral
	 	 	7	 
	 	 	5.3      Litigation
	 	 	7	 
	 	 	5.4      No Material Adverse Change in Financial Statements
	 	 	7	 
	 	 	5.5      Solvency
	 	 	7	 
	 	 	5.6      Regulatory Compliance
	 	 	8	 
	 	 	5.7      Investments in Subsidiaries
	 	 	8	 
	 	 	5.8      Full Disclosure
	 	 	8	 
	 	 	 
	 	 	 	 
	6	 	AFFIRMATIVE COVENANTS
	 	 	8	 
	 	 	6.1      Government Compliance
	 	 	8	 
	 	 	6.2      Financial Statements, Reports, Certificates
	 	 	8	 
	 	 	6.3      Inventory; Returns
	 	 	9	 
	 	 	6.4      Taxes
	 	 	9	 
	 	 	6.5      Insurance
	 	 	9	 
	 	 	6.6      Primary Accounts
	 	 	9	 
	 	 	6.7      Further Assurances
	 	 	9	 
	 	 	 
	 	 	 	 
	7	 	NEGATIVE COVENANTS
	 	 	9	 
	 	 	7.1      Dispositions
	 	 	10	 
	 	 	7.2      Changes in Business, Ownership, Management or Locations of Collateral
	 	 	10	 
	 	 	7.3      Mergers or Acquisitions
	 	 	10	 
	 	 	7.4      Indebtedness
	 	 	10	 
	 	 	7.5      Encumbrance
	 	 	10	 
	 	 	7.6      Distributions; Investments
	 	 	11	 
	 	 	7.7      Transactions with Affiliates
	 	 	11	 
	 	 	7.8      Subordinated Debt
	 	 	11	 
	 	 	7.9      Compliance
	 	 	11	 
	 	 	 
	 	 	 	 
	8	 	EVENTS OF DEFAULT
	 	 	11	 
	 	 	8.1      Payment Default
	 	 	11	 
	 	 	8.2      Covenant Default
	 	 	11	 
	 	 	8.3      Material Adverse Change
	 	 	12	 
	 	 	8.4      Attachment
	 	 	12	 
	 	 	8.5      Insolvency
	 	 	12	 

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	 	 	 	 	Page	 
	 	 	8.6      Other Agreements
	 	 	12	 
	 	 	8.7      Judgments
	 	 	12	 
	 	 	8.8      Misrepresentations
	 	 	12	 
	 	 	 
	 	 	 	 
	9	 	BANK’S RIGHTS AND REMEDIES
	 	 	12	 
	 	 	9.1      Rights and Remedies
	 	 	12	 
	 	 	9.2      Power of Attorney
	 	 	13	 
	 	 	9.3      Bank Expenses
	 	 	13	 
	 	 	9.4      Bank’s Liability for Collateral
	 	 	13	 
	 	 	9.5      Remedies Cumulative
	 	 	14	 
	 	 	9.6      Demand Waiver
	 	 	14	 
	 	 	 
	 	 	 	 
	10	 	NOTICES
	 	 	14	 
	 	 	 
	 	 	 	 
	11	 	CHOICE OF
LAW, VENUE AND JURY TRIAL WAIVER
	 	 	14	 
	 	 	 
	 	 	 	 
	12	 	GENERAL PROVISIONS
	 	 	14	 
	 	 	12.1    Successors and Assigns
	 	 	14	 
	 	 	12.2    Indemnification
	 	 	14	 
	 	 	12.3    Time of Essence
	 	 	15	 
	 	 	12.4    Severability of Provision
	 	 	15	 
	 	 	12.5    Amendments in Writing, Integration
	 	 	15	 
	 	 	12.6    Counterparts
	 	 	15	 
	 	 	12.7    Survival
	 	 	15	 
	 	 	12.8    Confidentiality
	 	 	15	 
	 	 	12.9    Attorneys’ Fees, Costs and Expenses
	 	 	15	 
	 	 	 
	 	 	 	 
	13	 	DEFINITIONS
	 	 	15	 
	 	 	13.1 Definitions
	 	 	16	 

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     This LOAN AND SECURITY AGREEMENT dated March 20, 2002, between SILICON VALLEY BANK (“Bank”),
whose address is 3003 Tasman Drive, Santa Clara, California 95054 and ALEXZA MOLECULAR DELIVERY
CORPORATION (“Borrower”), whose address is 2375 Garcia Ave., Mountain View, California 94043
provides the terms on which Bank will lend to Borrower and Borrower will repay Bank. The parties
agree as follows:

1 ACCOUNTING AND OTHER TERMS

     Accounting terms not defined in this Agreement will be construed following GAAP.
Calculations and determinations must be made following GAAP. The term “financial statements”
includes the notes and schedules. The terms “including” and “includes” always mean “including (or
includes) without limitation,” in this or any Loan Document.

2 LOAN AND TERMS OF PAYMENT 

2.1 Promise to Pay.

     Borrower promises to pay Bank the unpaid principal amount of all Credit Extensions and
interest on the unpaid principal amount of the Credit Extensions.

2.1.1 Equipment Facility.

     (a) Subject to the terms and conditions of this Agreement, Bank agrees to lend to Borrower,
from time to time prior to the Commitment Termination Date, equipment advances (each an “Equipment
Advance” and collectively the “Equipment Advances”) in an aggregate amount not to exceed the
Committed Equipment Line. When repaid, the Equipment Advances may not be re-borrowed. The
proceeds of the Equipment Advances will be used solely to reimburse Borrower for the purchase of
Eligible Equipment purchased within 90 days of the Equipment Advance, provided however, the
proceeds of the initial Equipment Advance may be used to finance (i) Eligible Equipment purchased
as far back as November 20, 2001 and (ii) Other Equipment up to $165,057 without invoices. Each
Equipment Advance shall be considered a promissory note evidencing the amounts due hereunder for
all purposes. Bank’s obligation to lend hereunder shall terminate on the earlier of (i) the
occurrence and continuance of an Event of Default, or (ii) the Commitment Termination Date. For
purposes of this Section, the minimum amount of each Equipment Advance is $100,000 (with the
exception of the initial Equipment Advance and the final Equipment Advance which may be a lesser
amount) and the maximum number of Equipment Advances that will be made is 6.

     (b) To obtain an Equipment Advance, Borrower will deliver to Bank a completed supplement in
substantially the form attached as Exhibit C (“Loan Supplement”) signed by a Responsible Officer or
his or her designee, copies of invoices for the Financed Equipment and such additional information
as Bank may request at least five (5) Business Days before the proposed funding date (the “Funding
Date”). On each Funding Date, Bank will specify in the Loan Supplement for each Equipment
Advance, the Basic Rate, the Loan Factor, and the Payment Dates. If Borrower satisfies the
conditions of each Equipment Advance specified herein, Bank will disburse such Equipment Advance by
internal transfer to Borrower’s deposit account with Bank. Each Equipment Advance may not exceed
100% of the Original Stated Cost. Notwithstanding the foregoing, Equipment Advances used to
reimburse Borrower for the purchase of Eligible Equipment made beyond 90 days of the Equipment
Advance approved by Bank shall be advanced at 100% of the net book value in accordance with GAAP.

     (c) Bank’s obligation to lend the undisbursed portion of the Committed Equipment Line will
terminate if, in Bank’s sole discretion, there has been a material adverse change in the general
affairs, management, results of operation, condition (financial or otherwise) or the

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prospects of Borrower, whether or not arising from transactions in the ordinary course of
business, or there has been any material adverse deviation by Borrower, in excess of 25%, from
Borrower’s most recent cash and operating forecast presented to and accepted by Bank prior to the
execution of this Agreement.

2.2 Interest Rate, Payments.

     (a) Principal and Interest Payments On Payment Dates. Borrower will repay the Equipment
Advances on the terms provided in the Loan Supplement. Borrower will make payments monthly in
advance of principal and accrued interest for each Equipment Advance (collectively, “Scheduled
Payments”), on the first Business Day of the month following the Funding Date (or commencing on the
Funding Date if the Funding Date is the first Business Day of the month) with respect to such
Equipment Advance and continuing thereafter during the Repayment Period on the first Business Day
of each calendar month (each a “Payment Date”), in an amount equal to the Loan Factor multiplied by
the Loan Amount for such Equipment Advance as of such Payment Date. All unpaid principal and
accrued interest is due and payable in full on the last Payment Date with respect to such Equipment
Advance. Payments received after 12:00 noon Pacific time are considered received at the opening of
business on the next Business Day. An Equipment Advance may only be prepaid in accordance with
Section 2.2(f).

     (b) Interest Rate. Borrower will pay interest on the Payment Dates (as described above) at the
per annum rate of interest equal to the Basic Rate determined by Bank as of the Funding Date for
each Equipment Advance in accordance with the definition of the Basic Rate. Any amounts
outstanding during the continuance of an Event of Default shall bear interest at a per annum rate
equal to the Basic Rate plus five percent (5%). If any change in the law increases Bank’s
expenses or decreases its return from the Equipment Advances, Borrower will pay Bank upon request
the amount of such increase or decrease.

     (c) Interim Payment. In addition to the Scheduled Payments, on the Funding Date for each
Equipment Advance (unless the Funding Date is the first Business Day of the month) Borrower shall
pay to Bank, on behalf of Bank, an amount (the “Interim Payment”) equal to (i) the initial
Equipment Advance multiplied by (ii) the sum of the Prime Rate plus 1.5 percentage points, divided
by (iii) 360 days and then multiplied by (iv) the number of days from the actual Funding Date of
the Equipment Advance until the first day of the month following such Equipment Advance.

     (d) Final Payment. On the Maturity Date with respect to each Equipment Advance, Borrower will
pay, in addition to the unpaid principal and accrued interest and all other amounts due on such
date with respect to such Equipment Advance, an amount equal to the Final Payment.

     (e) Mandatory Prepayment Upon an Acceleration. If the Equipment Advances are accelerated
following the occurrence of an Event of Default or otherwise, then Borrower will immediately pay to
Bank (i) all unpaid Scheduled Payments (including principal and interest) with respect to each
Equipment Advance, (ii) all remaining Scheduled Payments (including principal and interest unpaid)
(iii) all accrued unpaid interest, including the default rate of interest, to the date of the
prepayment, (iv) the Final Payment and (v) all other sums, if any, that shall have become due and
payable with respect to any Equipment Advance.

     (f) Permitted Prepayment of Loans. Borrower shall have the option to prepay all, but not less
than all, of the Equipment Advances advanced by Bank under this
Agreement, provided Borrower (i) provides written notice to Bank of its election to prepay the Equipment Advances
at least thirty (30) days prior to such prepayment, and (ii) pays, on the date of the prepayment
(A) all accrued unpaid interest with respect to each Equipment Advance to the date of prepayment;
(B) all outstanding principal with respect to each Equipment Advance (C) the Final Payment; and

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(D) all other sums, if any, that shall have become due and payable hereunder with respect to
this Agreement.

2.2.1 Request to Debit Accounts.

     Bank
may debit any of Borrower’s deposit accounts including Account
Number                                          for principal and interest payments or any amounts Borrower
owes Bank when due. Bank will notify Borrower when it debits Borrower’s accounts. These debits
are not a set-off.

2.3 Fees.

     Borrower will pay:

     (a) Good Faith Deposit. Already paid; and

     (b) Bank Expenses. All Bank Expenses (including reasonable attorneys’ fees and reasonable
expenses) incurred through and after the date of this Agreement, are payable when due.

3 CONDITIONS OF LOANS

3.1 Conditions Precedent to Initial Credit Extension.

     Bank’s obligation to make the initial Credit Extension is subject to the condition precedent that
it receive the agreements, documents and fees it requires.

3.2 Conditions Precedent to all Credit Extensions.

     Bank’s obligations to make each Credit Extension, including the initial Credit Extension, is
subject to the following:

     (a) timely receipt of any Payment/Advance Form;

     (b) the representations and warranties in Section 5 must be materially true on the date of the
Payment/Advance Form and on the effective date of each Credit Extension and no Event of Default may
have occurred and be continuing, or result from the Credit Extension. Each Credit Extension is
Borrower’s representation and warranty on that date that the representations and warranties of
Section 5 remain true; and

     (c) Bank is in receipt of Borrower’s financial projections pursuant to Section 6.2.

4 CREATION OF SECURITY INTEREST

4.1 Grant of Security Interest.

     Borrower grants Bank a continuing security interest in all presently existing and later acquired
Collateral to secure all Obligations and performance of each of Borrower’s duties under the Loan
Documents. Except for Permitted Liens, any security interest will be a first priority security
interest in the Collateral. Bank may place a “hold” on any deposit account pledged as Collateral.
If this Agreement is terminated, Bank’s lien and security interest in the Collateral will continue
until Borrower fully satisfies its Obligations.

4.2 Authorization of File.

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     Borrower authorizes Bank to file financing statements without notice to Borrower, with all
appropriate jurisdictions, as Bank deems appropriate, in order to perfect or protect Bank’s
interest in the Collateral.

5 REPRESENTATIONS AND WARRANTIES

     Borrower represents and warrants as follows:

5.1 Due Organization and Authorization.

     Borrower and each Subsidiary is duly existing and in good standing in its state of formation and
qualified and licensed to do business in, and in good standing in, any state in which the conduct
of its business or its ownership of property requires that it be qualified, except where the
failure to do so could not reasonably be expected to cause a Material Adverse Change. Borrower has
not changed its state of formation or its organizational structure or type or any organizational
number (if any) assigned by its jurisdiction of formation.

     The execution, delivery and performance of the Loan Documents have been duly authorized, and do not
conflict with Borrower’s formation documents, nor constitute an event of default under any material
agreement by which Borrower is bound. Borrower is not in default under any agreement to which or by
which it is bound in which the default could reasonably be expected to cause a Material Adverse
Change.

5.2 Collateral.

     Borrower has good title to the Collateral, free of Liens except Permitted Liens or Borrower has
Rights to each asset that is Collateral. Borrower has no other deposit account, other than the
deposit accounts described in the Schedule. The Accounts are bona fide, existing obligations, and
the service or property has been performed or delivered to the account debtor or its agent for
immediate shipment to and unconditional acceptance by the account debtor. The Collateral is not in
the possession of any third party bailee (such as at a warehouse). In the event that Borrower,
after the date hereof, intends to store or otherwise deliver the Collateral to such a bailee, then
Borrower will receive the prior written consent of Bank and such bailee must acknowledge in writing
that the bailee is holding such Collateral for the benefit of Bank. All Inventory is in all
material respects of good and marketable quality, free from material defects.

5.3 Litigation.

     Except as shown in the Schedule, there are no actions or proceedings pending or, to the knowledge
of Borrower’s Responsible Officers and legal counsel, threatened by or against Borrower or any
Subsidiary in which a likely adverse decision could reasonably be expected to cause a Material
Adverse Change.

5.4 No Material Adverse Change in Financial Statements.

     All consolidated financial statements for Borrower, and any Subsidiary, delivered to Bank fairly
present in all material respects Borrower’s consolidated financial condition and Borrower’s
consolidated results of operations. There has not been any material deterioration in Borrower’s
consolidated financial condition since the date of the most recent financial statements submitted
to Bank.

5.5 Solvency.

     The fair salable value of Borrower’s assets (including goodwill minus disposition costs)
exceeds the fair value of its liabilities; the Borrower is not left with unreasonably small capital
after

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the transactions in this Agreement; and Borrower is able to pay its debts (including trade debts)
as they mature.

5.6 Regulatory Compliance.

     Borrower is not an “investment company” or a company “controlled” by an “investment company” under
the Investment Company Act. Borrower is not engaged as one of its important activities in extending
credit for margin stock (under Regulations T and U of the Federal Reserve Board of Governors).
Borrower has complied in all material respects with the Federal Fair Labor Standards Act. Borrower
has not violated any laws, ordinances or rules, the violation of which could reasonably be expected
to cause a Material Adverse Change. None of Borrower’s or any Subsidiary’s properties or assets has
been used by Borrower or any Subsidiary or, to the best of Borrower’s knowledge, by previous
Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other
than legally. Borrower and each Subsidiary has timely filed all required tax returns and paid, or
made adequate provision to pay, all material taxes, except those being contested in good faith with
adequate reserves under GAAP. Borrower and each Subsidiary has obtained all consents, approvals and
authorizations of, made all declarations or filings with, and given all notices to, all government
authorities that are necessary to continue its business as currently conducted, except where the
failure to do so could not reasonably be expected to cause a Material Adverse Change.

5.7 Investments in Subsidiaries.

     Borrower does not own any stock, partnership interest or other equity securities except for
Permitted Investments.

5.8 Full Disclosure.

     No written representation, warranty or other statement of Borrower in any certificate or written
statement given to Bank (taken together with all such written certificates and written statements
to Bank) contains any untrue statement of a material fact or omits to state a material fact
necessary to make the statements contained in the certificates or statements not misleading. It
being recognized by Bank that the projections and forecasts provided by Borrower in good faith and
based upon reasonable assumptions are not viewed as facts and that actual results during the period
or periods covered by such projections and forecasts may differ from the projected and forecasted
results.

6 AFFIRMATIVE COVENANTS

     Borrower will do all of the following for so long as Bank has an obligation to lend, or there are
outstanding Obligations:

6.1 Government Compliance.

     Borrower will maintain its and all Subsidiaries’ legal existence and good standing in its
jurisdiction of formation and maintain qualification in each jurisdiction in which the failure to
so qualify would reasonably be expected to cause a material adverse effect on Borrower’s business
or operations. Borrower will comply, and have each Subsidiary comply, with all laws, ordinances and
regulations to which it is subject, noncompliance with which could have a material adverse effect
on Borrower’s business or operations or would reasonably be expected to cause a Material Adverse
Change.

6.2 Financial Statements, Reports, Certificates.

     (a) Borrower will deliver to Bank: (i) as soon as available, but no later than 30 days after the
last day of each month, a company prepared consolidated balance sheet and income

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statement covering Borrower’s consolidated operations during the period certified by a Responsible
Officer and in a form acceptable to Bank; (ii) when required by Borrower’s investors an/or
corporate partners, as soon as available, but no later than 120 days after the last day of
Borrower’s fiscal year, audited consolidated financial statements prepared under GAAP, consistently
applied, together with an unqualified opinion on the financial statements from an independent
certified public accounting firm reasonably acceptable to Bank; (iii) a prompt report of any legal
actions pending or threatened against Borrower or any Subsidiary that could result in damages or
costs to Borrower or any Subsidiary of $100,000 or more; (iv) as soon as available, but no later
than 30 days after the last day of Borrower’s fiscal year, financial projections approved by
Borrower’s board of directors (Borrower may submit modified financial projections up to two times
per fiscal year, subject to Board approval and Bank’s acceptance) and (v) budgets, sales
projections, operating plans or other financial information Bank reasonably requests.

     (b) Allow Bank to audit Borrower’s Collateral at Borrower’s expense. Such audits will be conducted
only at such times as an Event of Default has occurred and is continuing.

6.3 Inventory; Returns.

     Borrower will keep all Inventory in good and marketable condition, free from material defects.
Returns and allowances between Borrower and its account debtors will follow Borrower’s customary
practices as they exist at execution of this Agreement. Borrower must promptly notify Bank of all
returns, recoveries, disputes and claims, that involve more than $50,000.

6.4 Taxes.

     Borrower will make, and cause each Subsidiary to make, timely payment of all material federal,
state, and local taxes or assessments and will deliver to Bank, on demand, appropriate certificates
attesting to the payment.

6.5 Insurance.

     Borrower will keep its business and the Collateral insured for risks and in amounts, as Bank
may reasonably request. Insurance policies will be in a form, with companies, and in amounts that
are satisfactory to Bank in Bank’s reasonable discretion. All property policies will have a
lender’s loss payable endorsement showing Bank as an additional loss payee and all liability
policies will show the Bank as an additional insured and provide that the insurer must give Bank at
least 20 days notice before canceling its policy. At Bank’s request, Borrower will deliver
certified copies of policies and evidence of all premium payments. Proceeds payable under any
policy will, at Bank’s option, be payable to Bank on account of the Obligations.

6.6 Primary Accounts.

     Borrower will maintain its primary operating accounts with Bank.

6.7 Further Assurances.

     Borrower will execute any further instruments and take further action as Bank reasonably
requests to perfect or continue Bank’s security interest in the Collateral or to effect the
purposes of this Agreement.

7 NEGATIVE COVENANTS

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     Borrower will not do any of the following without Bank’s prior written consent, which will
not be unreasonably withheld, for so long as Bank has an obligation to lend and there are any
outstanding Obligations:

7.1 Dispositions.

     Convey, sell, lease, transfer or otherwise dispose of (collectively “Transfer”), or permit any of
its Subsidiaries to Transfer, all or any part of its business or property, except for
Transfers (i) of Inventory in the ordinary course of business; (ii) of non-exclusive licenses and
similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary
course of business; or (iii) of worn-out or obsolete Equipment. Notwithstanding the foregoing,
Borrower may, in the ordinary course of business, license its intellectual property on a
non-exclusive basis. Further, Borrower may, in the ordinary course of business, license its
intellectual property on an exclusive basis, provided that (i) such exclusive licenses only permit
the use or practice of the intellectual property to specific indications and geographic regions and
does not impair Borrower’s ability to commercialize its intellectual property in its business
markets in the United States as determined by Borrower’s Board
of Directors in good faith. Further,
Borrower shall not execute any negative pledge agreement related to any and all intellectual
property as described above to any third party.

7.2
Changes in Business, Ownership, Management or Locations of Collateral.

     Engage in or permit any of its Subsidiaries to engage in any business other than the businesses
currently engaged in by Borrower or reasonably related thereto or have a material change in its
ownership or management of greater than 25% (other than by the sale of Borrower’s equity securities
in a public offering or to equity investors, so long as Borrower identifies the equity
investors prior to the closing of the investment). Borrower will not, without at least 30 days
prior written notice, relocate its chief executive office, change its state of formation (including
reincorporation), change its organizational number or name or add any new offices or business
locations (such as warehouses) in which Borrower maintains or stores over $5,000 in Collateral.
Bank hereby acknowledges Borrower’s anticipated move to
1001 East Meadow Circle, Palo Alto, CA 94303 on or about April 8, 2002.

7.3 Mergers or Acquisitions.

     Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other
Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the
capital stock or property of another Person, except where (i) no Event of Default has occurred and
is continuing or would result from such action during the term of this Agreement and (ii)
such transaction would not result in a decrease of more than 25% of Tangible Net Worth. A
Subsidiary may merge or consolidate into another Subsidiary or into Borrower.

7.4 Indebtedness.

     Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other
than Permitted Indebtedness.

7.5 Encumbrance.

     Create, incur, or allow any Lien on any of its property, or assign or convey any right to receive
income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for
Permitted Liens, or permit any Collateral not to be subject to the first priority security interest
granted here, subject to Permitted Liens.

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7.6 Distributions; Investments.

     Directly or indirectly acquire or own any Person, or make any Investment in any Person, other
than Permitted Investments, or permit any of its Subsidiaries to do so. Pay any dividends or make
any distribution or payment or redeem, retire or purchase any capital stock, except for repurchases
of stock from former employees or directors of Borrower under the term of applicable repurchase
agreements in an aggregate amount not to exceed $ 175,000 in any fiscal year. This cap may be
reviewed annually by Bank and Borrower CC/MF.

7.7 Transactions with Affiliates.

     Directly or indirectly enter into or permit to exist any material transaction with any
Affiliate of Borrower except for transactions that are in the ordinary course of Borrower’s
business, upon fair and reasonable terms that are no less favorable to Borrower than would be
obtained in an arm’s length transaction with a nonaffiliated Person.

7.8 Subordinated Debt.

     Make or permit any payment on any Subordinated Debt, except under the terms of the
Subordinated Debt, or amend any provision in any document relating to the Subordinated Debt without
Bank’s prior written consent.

7.9 Compliance.

     Become an “investment company” or a company controlled by an “investment company,” under the
Investment Company Act of 1940 or undertake as one of its important activities extending credit to
purchase or carry margin stock, or use the proceeds of any Credit Extension for that purpose; fail
to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited
Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards
Act or violate any other law or regulation, if the violation could reasonably be expected to have a
material adverse effect on Borrower’s business or operations or would reasonably be expected to
cause a Material Adverse Change, or permit any of its Subsidiaries to do so.

8 EVENTS OF DEFAULT

     Any one of the following is an Event of Default:

8.1 Payment Default.

     If Borrower fails to pay any of the Obligations within 3 days after their due date, however,
during such period no Credit Extensions will be made;

8.2 Covenant Default.

     (a) If Borrower fails to perform any obligation under Sections 6.2 or 6.7 or violates any
of the covenants contained in Article 7 of this Agreement, or

     (b) If Borrower fails or neglects to perform, keep, or observe any other material term,
provision, condition, covenant, or agreement contained in this Agreement, in any of the Loan
Documents, or in any other present or future agreement between Borrower and Bank and as to any
default under such other term, provision, condition, covenant or agreement that can be cured, has
failed to cure such default within ten (10) days after the occurrence thereof; provided, however,
that if the default cannot by its nature be cured within the ten (10) day period or cannot after
diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely
to be cured within a reasonable time, then Borrower shall have an additional reasonable period
(which shall not in any case exceed thirty (30) days) to attempt to cure such default, and

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within such reasonable time period the failure to have cured such default shall not be deemed an
Event of Default (provided that no Credit Extensions will be made during such cure period);

8.3 Material Adverse Change.

     If there (i) occurs a material adverse change in the business, operations, or financial condition
of the Borrower, or (ii) is a material impairment of the prospect of repayment of any portion of
the Obligations; or (iii) is a material impairment of the value or priority of Bank’s security
interests in the Collateral (the foregoing being defined as a “Material Adverse Change”).

8.4 Attachment.

     If any material portion of Borrower’s assets is attached, seized, levied on, or comes into
possession of a trustee or receiver and the attachment, seizure or levy is not removed in 10 days,
or if Borrower is enjoined, restrained, or prevented by court order from conducting a material part
of its business or if a judgment or other claim becomes a Lien on a material portion of Borrower’s
assets, or if a notice of lien, levy, or assessment is filed against any of Borrower’s assets by
any government agency and not paid within 10 days after Borrower receives notice. These are not
Events of Default if stayed or if a bond is posted pending contest by Borrower (but no Credit
Extensions will be made during the cure period);

8.5 Insolvency.

     If Borrower becomes insolvent or if Borrower begins an Insolvency Proceeding or an Insolvency
Proceeding is begun against Borrower and not dismissed or stayed within 30 days (but no Credit
Extensions will be made before any Insolvency Proceeding is dismissed);

8.6 Other Agreements.

     If there is a default in any agreement between Borrower and a third party that gives the third
party the right to accelerate any Indebtedness exceeding $100,000 or that could cause a Material
Adverse Change;

8.7 Judgments.

     If a money judgment(s) in the aggregate of at least $50,000 is rendered against Borrower and is
unsatisfied and unstayed for 10 days (but no Credit Extensions will be made before the judgment is
stayed or satisfied); or

8.8 Misrepresentations.

     If Borrower or any Person acting for Borrower makes any material misrepresentation or material
misstatement now or later in any warranty or representation in this Agreement or in any writing
delivered to Bank or to induce Bank to enter this Agreement or any Loan Document.

9 BANK’S RIGHTS AND REMEDIES

9.1 Rights and Remedies.

     When an Event of Default occurs and continues Bank may, without notice or demand, do any or all of
the following:

     (a) Declare all Obligations immediately due and payable (but if an Event of Default described in
Section 8.5 occurs all Obligations are immediately due and payable without any action by Bank);

12

 

     (b) Stop advancing money or extending credit for Borrower’s benefit under this Agreement or
under any other agreement between Borrower and Bank;

     (c) Settle or adjust disputes and claims directly with account debtors for amounts, on terms and
in any order that Bank considers advisable; notify any Person owing Borrower money of Bank’s
security interest in the funds and verify the amount of the Account. Borrower must collect all
payments in trust for Bank and, if requested by Bank, immediately deliver the payments to Bank in
the form received from the account debtor, with proper endorsements for deposit;

     (d) Make any payments and do any acts it considers necessary or reasonable to protect its
security interest in the Collateral. Borrower will assemble the Collateral if Bank requires and
make it available as Bank designates. Bank may enter premises where the Collateral is located,
take and maintain possession of any part of the Collateral, and pay, purchase, contest, or
compromise any Lien which appears to be prior or superior to its security interest and pay all
expenses incurred. Borrower grants Bank a license to enter and occupy any of its premises, without
charge, to exercise any of Bank’s rights or remedies;

     (e) Apply to the Obligations any (i) balances and deposits of Borrower it holds, or (ii) any
amount held by Bank owing to or for the credit or the account of Borrower;

     (f) Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for
sale, and sell the Collateral; and

     (g) Dispose of the Collateral according to the Code.

9.2 Power of Attorney.

     Effective only when an Event of Default occurs and continues, Borrower irrevocably appoints
Bank as its lawful attorney to: (i) endorse Borrower’s name on any checks or other forms of payment
or security; (ii) sign Borrower’s name on any invoice or bill of lading for any Account or drafts
against account debtors, (iii) make, settle, and adjust all claims under Borrower’s insurance
policies; (iv) settle and adjust disputes and claims about the Accounts directly with account
debtors, for amounts and on terms Bank determines reasonable; and (v) transfer the Collateral into
the name of Bank or a third party as the Code permits. Bank may exercise the power of attorney to
sign Borrower’s name on any documents necessary to perfect or continue the perfection of any
security interest regardless of whether an Event of Default has occurred. Bank’s appointment as
Borrower’s attorney in fact, and all of Bank’s rights and powers, coupled with an interest, are
irrevocable until all Obligations have been fully repaid and performed and Bank’s obligation to
provide Credit Extensions terminates.

9.3 Bank Expenses.

     If Borrower fails to pay any amount or furnish any required proof of payment to third persons,
Bank may make all or part of the payment or obtain insurance policies required in Section 6.5, and
take any action under the policies Bank deems prudent. Any amounts paid by Bank are Bank Expenses
and immediately due and payable, bearing interest at the then applicable rate and secured by the
Collateral. No payments by Bank are deemed an agreement to make similar payments in the future or
Bank’s waiver of any Event of Default.

9.4 Bank’s Liability for Collateral.

     If Bank complies with reasonable banking practices and Section 9-207 of the Code, it is not
liable for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c)
any diminution in the value of the Collateral; or (d) any act or default of any carrier,
warehouseman, bailee, or other person. Except as provided above, Borrower bears all risk of loss,
damage or destruction of the Collateral.

13

 

9.5 Remedies Cumulative.

     Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements are
cumulative. Bank has all rights and remedies provided under the Code, by law, or in equity. Bank’s
exercise of one right or remedy is not an election, and Bank’s waiver of any Event of Default is
not a continuing waiver. Bank’s delay is not a waiver, election, or acquiescence. No waiver is
effective unless signed by Bank and then is only effective for the specific instance and purpose
for which it was given.

9.6 Demand Waiver.

     Borrower waives demand, notice of default or dishonor, notice of payment and nonpayment, notice of
any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of
accounts, documents, instruments, chattel paper, and guarantees held by Bank on which Borrower is
liable.

10 NOTICES

     All notices or demands by any party about this Agreement or any other related agreement must be in
writing and be personally delivered or sent by an overnight delivery service, by certified mail,
postage prepaid, return receipt requested, or by telefacsimile to the addresses set forth at the
beginning of this Agreement. A party may change its notice address by giving the other party
written notice.

11 CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER

     California law governs the Loan Documents without regard to principles of conflicts of law.
Borrower and Bank each submit to the exclusive jurisdiction of the State and Federal courts in
Santa Clara County, California.

BORROWER AND BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING
OUT OF ANY OF THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH
OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO
THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL.

12 GENERAL PROVISIONS

12.1 Successors and Assigns.

     This Agreement binds and is for the benefit of the successors and permitted assigns of each party.
Borrower may not assign this Agreement or any rights under it without Bank’s prior written consent
which may be granted or withheld in Bank’s discretion. Bank has the right, without the consent of
or notice to Borrower, to sell, transfer, negotiate, or grant participation in all or any part of,
or any interest in, Bank’s obligations, rights and benefits under this Agreement.

12.2 Indemnification.

     Borrower will indemnify, defend and hold harmless Bank and its officers, employees, and agents
against: (a) all obligations, demands, claims, and liabilities asserted by any other party in
connection with the transactions contemplated by the Loan Documents; and (b) all losses or Bank
Expenses incurred, or paid by Bank from, following, or consequential to transactions between Bank
and Borrower (including reasonable attorneys fees and expenses), except for losses caused by Bank’s
gross negligence or willful misconduct.

14

 

12.3 Time of Essence.

     Time is of the essence for the performance of all obligations in this Agreement.

12.4 Severability of Provision.

     Each provision of this Agreement is severable from every other provision in determining the
enforceability of any provision.

12.5 Amendments in Writing, Integration.

     All amendments to this Agreement must be in writing and signed by Borrower and Bank. This
Agreement represents the entire agreement about this subject matter, and supersedes prior
negotiations or agreements. All prior agreements, understandings, representations, warranties, and
negotiations between the parties about the subject matter of this Agreement merge into this
Agreement and the Loan Documents.

12.6 Counterparts.

     This Agreement may be executed in any number of counterparts and by different parties on
separate counterparts, each of which, when executed and delivered, are an original, and all taken
together, constitute one Agreement.

12.7 Survival.

     All covenants, representations and warranties made in this Agreement continue in full force
while any Obligations remain outstanding. The obligations of Borrower in Section 12.2 to indemnify
Bank will survive until all statutes of limitations for actions that may be brought against Bank
have run.

12.8 Confidentiality.

     In handling any confidential information, Bank will exercise the same degree of care that it
exercises for its own proprietary information, but disclosure of information may be made (i) to
Bank’s subsidiaries or affiliates as may be required in connection with their
business with Borrower, (ii) to prospective transferees or purchasers of any interest in the loans
(provided, however, Bank shall use commercially reasonable efforts in obtaining such prospective
transferee or purchasers agreement of the terms of this provision), (iii) as required by law,
regulation, subpoena, or other order, (iv) as required in connection with Bank’s examination or
audit and (v) as Bank considers appropriate exercising remedies under this Agreement. Confidential
information does not include information that either: (a) is in the public domain or in Bank’s
possession when disclosed to Bank, or becomes part of the public domain after disclosure to Bank;
or (b) is disclosed to Bank by a third party, if Bank does not know that the third party is
prohibited from disclosing the information.

12.9 Attorneys’ Fees, Costs and Expenses.

     In any action or proceeding between Borrower and Bank arising out of the Loan Documents, the
prevailing party will be entitled to recover its reasonable attorneys’ fees and other reasonable
costs and expenses incurred, in addition to any other relief to which it may be entitled.

13 DEFINITIONS

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13.1 Definitions.

     In this Agreement:

     “Accounts” are all existing and later arising accounts, contract rights, and other obligations owed
Borrower in connection with its sale or lease of goods (including licensing software and other
technology) or provision of services, all credit insurance,
guaranties, other security and all
merchandise returned or reclaimed by Borrower and Borrower’s Books relating to any of the
foregoing, as such definition may be amended from time to time according to the Code.

     “Affiliate” of a Person is a Person that owns or controls directly or indirectly the Person, any
Person that controls or is controlled by or is under common control with the Person, and each of
that Person’s senior executive officers, directors, partners and, for any Person that is a limited
liability company, that Person’s managers and members.

     “Bank Expenses” are all audit fees and expenses and reasonable costs and expenses (including
reasonable attorneys’ fees and expenses) for preparing, negotiating, administering, defending and
enforcing the Loan Documents (including appeals or Insolvency Proceedings).

     “Basic Rate” is, as of the Funding Date, the per annum rate of interest (based on a year of 360
days) equal to the sum of (a) the Prime Rate on the day the Loan Supplement is prepared, plus (b)
the Loan Margin.

     “Borrower’s Books” are all Borrower’s books and records including ledgers, records regarding
Borrower’s assets or liabilities, the Collateral, business operations or financial condition and
all computer programs or discs or any equipment containing the information.

     “Business Day” is any day that is not a Saturday, Sunday or a day on which the Bank is closed.

     “Closing Date” is the date of this Agreement.

     “Code” is the California Uniform Commercial Code, as applicable.

     “Collateral” is the property described on Exhibit A.

     “Committed Equipment Line” is a Credit Extension of up to $1,000,000.

     “Commitment Termination Date” is March 1, 2003.

     “Contingent Obligation” is, for any Person, any direct or indirect liability, contingent or not, of
that Person for (i) any indebtedness, lease, dividend, letter of credit or other obligation of
another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or
sold with recourse by that Person, or for which that Person is directly or indirectly liable; (ii)
any obligations for undrawn letters of credit for the account of that Person; and (iii) all
obligations from any interest rate, currency or commodity swap agreement, interest rate cap or
collar agreement, or other agreement or arrangement designated to protect a Person against
fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent
Obligation” does not include endorsements in the ordinary course of business. The amount of a
Contingent Obligation is the stated or determined amount of the primary obligation for which the
Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability
for it determined by the Person in good faith; but the amount may not exceed the maximum of the
obligations under the guarantee or other support arrangement.

16

 

     “Credit Extension” is each Equipment Advance or any other extension of credit by Bank for
Borrower’s benefit.

     “Eligible Equipment” is general purpose computer equipment, office equipment, test and laboratory
equipment, furnishings, and, subject to the limitations set forth below, Other Equipment that
complies with all of Borrower’s representations and warranties to Bank and which is acceptable to
Bank in all respects. All Equipment financed with the proceeds of Equipment Advances shall be new,
provided that Bank, in its sole discretion, may finance used equipment.

     “Equipment” is all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest.

     “Equipment Advance” is defined in Section 2.1.1.

     “ERISA” is the Employment Retirement Income Security Act of 1974, and its regulations.

     “Final Payment” is a payment (in addition to and not a substitution for the regular monthly
payments of principal plus accrued interest) due on the Maturity Date for such Equipment Advance
equal to the Loan Amount for such Equipment Advance multiplied by the Final Payment Percentage.

     “Final Payment Percentage” is, for each Equipment Advance, 6%.

     “Financed Equipment” is defined in
the Loan Supplement.

     “Funding Date” is any date on which an Equipment Advance is made to or on account of Borrower.

     “GAAP” is generally accepted accounting principles.

     “Indebtedness” is (a) indebtedness for borrowed money or the deferred price of property or
services, such as reimbursement and other obligations for surety bonds and letters of credit, (b)
obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease
obligations and (d) Contingent Obligations.

     “Insolvency Proceeding” are proceedings by or against any Person under the United States Bankruptcy
Code, or any other bankruptcy or insolvency law, including assignments for the benefit of
creditors, compositions, extensions generally with its creditors, or proceedings seeking
reorganization, arrangement, or other relief.

     “Inventory” is present and future inventory in which Borrower has any interest, including
merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and
finished products intended for sale or lease or to be furnished under a contract of service, of
every kind and description now or later owned by or in the custody or possession, actual or
constructive, of Borrower, including inventory temporarily out of its custody or possession or in
transit and including returns on any accounts or other proceeds (including insurance proceeds) from
the sale or disposition of any of the foregoing and any documents of title.

     “Investment” is any beneficial ownership of (including stock, partnership interest or other
securities) any Person, or any loan, advance or capital contribution to any Person.

     “Lien” is a mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance.

     “Loan Amount” is the aggregate amount of the Equipment Advance.

17

 

     “Loan Documents” are, collectively, this Agreement, any note, or notes or guaranties executed by
Borrower or Guarantor, and any other present or future agreement between Borrower and/or for the
benefit of Bank in connection with this Agreement, all as amended, extended or restated.

     “Loan Factor” is the percentage which results from amortizing the Equipment Advance over the
Repayment Period, using the Basic Rate as the interest rate.

     “Loan Margin” is 1.5 percentage points.

     “Loan Supplement” is attached as Exhibit C.

     “Material Adverse Change” is defined in Section 8.3.

     “Maturity Date” is, with respect to each Equipment Advance, the last day of the Repayment Period
for such Equipment Advance, or if earlier, the date of acceleration of such Equipment Advance by
Bank following an Event of Default.

     “Obligations” are debts, principal, interest, Bank Expenses and other amounts Borrower owes Bank
now or later, including cash management services, letters of credit and foreign exchange contracts,
if any and including interest accruing after Insolvency Proceedings begin and debts, liabilities,
or obligations of Borrower assigned to Bank.

     “Original Stated Cost” is (i), the original cost to the Borrower of the item of new Eligible
Equipment net of any and all freight, installation, tax or (ii) the fair market value assigned to
such item of used Eligible Equipment by mutual agreement of Borrower and Bank at the time of making
of the Equipment Advance.

     “Other Equipment” is leasehold improvements, intangible property such as computer software and
software licenses and other soft costs, including sales tax, freight and installation expense,
equipment specifically designed or manufactured for Borrower, other intangible property, limited
use property and other similar property. Unless otherwise agreed to by Bank: not more than 27% of
the Committed Equipment shall consist of Other Equipment.

     “Permitted Indebtedness” is:

     (a) Borrower’s indebtedness to Bank under this Agreement or any other Loan Document;

     (b) Indebtedness existing on the Closing Date and shown on the Schedule;

     (c) Subordinated Debt;

     (d) Indebtedness to trade creditors incurred in the ordinary course of business; and

     (e) Indebtedness secured by Permitted Liens.

     “Permitted Investments” are:

     (a) Investments shown on the Schedule and existing on the Closing Date; and

     (b) (i) marketable direct obligations issued or unconditionally guaranteed by the United States
or its agency or any State maturing within 1 year from its acquisition, (ii) commercial paper
maturing no more than 1 year after its creation and having the highest rating from either Standard
& Poor’s Corporation or Moody’s Investors Service, Inc., and (iii) Bank’s certificates of deposit
issued maturing no more than 1 year after issue.

18

 

     “Permitted Liens” are:

     (a) Liens existing on the Closing Date and shown on the Schedule or arising under this Agreement
or other Loan Documents;

     (b) Liens for taxes, fees, assessments or other government charges or levies, either not
delinquent or being contested in good faith and for which Borrower maintains adequate reserves on
its Books, if they have no priority over any of Bank’s security interests;

     (c) Purchase money Liens (i) on Equipment acquired or held by Borrower or its Subsidiaries
incurred for financing the acquisition of the Equipment, or (ii) existing on equipment when
acquired, if the Lien is confined to the property and improvements and the proceeds of the
equipment;

     (d) Licenses or sublicenses granted in the ordinary course of Borrower’s business and any
interest or title of a licensor or under any license or sublicense, if the licenses and sublicenses
permit granting Bank a security interest;

     (e) Leases or subleases granted in the ordinary course of Borrower’s business, including in
connection with Borrower’s leased premises or leased property;

     (f) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens
described in (a) through (c), but any extension, renewal or replacement Lien must be
limited to the property encumbered by the existing Lien and the principal amount of the
indebtedness may not increase.

     “Person” is any individual, sole proprietorship, partnership, limited liability company, joint
venture, company association, trust, unincorporated organization, association, corporation,
institution, public benefit corporation, firm, joint stock company, estate, entity or government
agency.

     “Prime Rate” is Bank’s most recently announced “prime rate,” even if it is not Bank’s lowest rate.

     “Repayment Period” as to the Equipment Advances, is 48 months.

     “Responsible Officer” is each of the Chief Executive Officer, the President, the Chief Financial
Officer and the Controller of Borrower.

     “Rights”, as applied to the Collateral, means the Borrower’s rights and interests in, and powers
with respect to, that Collateral, whatever the nature of those rights, interests and powers and, in
any event, including Borrower’s power to transfer rights in such Collateral to Bank.

     “Schedule” is any attached schedule of exceptions.

     “Subordinated Debt” is debt incurred by Borrower subordinated to Borrower’s indebtedness owed to
Bank and which is reflected in a written agreement in a manner and form acceptable to Bank and
approved by Bank in writing.

     “Subsidiary” is for any Person, or any other business entity of which more than 50% of the voting
stock or other equity interests is owned or controlled, directly or indirectly, by the Person or
one or more Affiliates of the Person.

     “Tangible Net Worth” is, on any date, the consolidated total assets of Borrower and its
Subsidiaries minus, (i) any amounts attributable to (a) goodwill, (b) intangible items such
as unamortized debt discount and expense, patents, trade and service marks and names, copyrights

19

 

and research and development expenses except prepaid expenses, and (c) reserves not already
deducted from assets, and (ii) Total Liabilities.

     “Total Liabilities” is on any day, obligations that should, under GAAP, be classified as
liabilities on Borrower’s consolidated balance sheet, including all Indebtedness, and current
portion Subordinated Debt allowed to be paid, but excluding all other Subordinated Debt.

BORROWER:

Alexza Molecular Delivery Corporation

	 	 	 	 	 
	By:

	 	/s/ Carol A. Christopher	 	 
	 

	 	 

	 	 
	Title:

	 	Chief Financial Officer	 	 

BANK:

SILICON VALLEY BANK

	 	 	 	 	 
	By:

	 	/s/ Mercy Forde	 	 
	 

	 	 

	 	 
	Title:

	 	VP	 	 

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EXHIBIT A

     The Collateral consists of all of Borrower’s right, title and interest in and to the following
whether owned now or hereafter arising and whether the Borrower has rights now or hereafter has
rights therein and wherever located:

     All goods and equipment now owned or hereafter acquired, including, without limitation, all
machinery, fixtures, vehicles (including motor vehicles and trailers), and any interest in any of
the foregoing, and all attachments, accessories, accessions, replacements, substitutions,
additions, and improvements to any of the foregoing, wherever located;

     All inventory, now owned or hereafter acquired, including, without limitation, all merchandise, raw
materials, parts, supplies, packing and shipping materials, work in process and finished products
including such inventory as is temporarily out of Borrower’s custody or possession or in transit
and including any returns upon any accounts or other proceeds, including insurance proceeds,
resulting from the sale or disposition of any of the foregoing and any documents of title
representing any of the above;

     All contract rights and general intangibles (as such definitions may be amended from time to time
according to the Code), now owned or hereafter acquired, including, without limitation, goodwill,
leases, license agreements, franchise agreements, blueprints, drawings, purchase orders, customer
lists, route lists, infringements, claims, computer programs, computer discs, computer tapes,
literature, reports, catalogs, design rights, income tax refunds, payments of insurance and rights
to payment of any kind,;

     All now existing and hereafter arising accounts, contract rights, royalties, license rights and all
other forms of obligations owing to Borrower arising out of the sale or lease of goods, the
licensing of technology or the rendering of services by Borrower (as such definitions may be
amended from time to time according to the Code) whether or not earned by performance, and any and
all credit insurance, insurance (including refund) claims and proceeds, guaranties, and other
security therefor, as well as all merchandise returned to or reclaimed by Borrower;

     All documents, cash, deposit accounts, securities, securities entitlements, securities accounts,
investment property, financial assets, letters of credit, letter of credit rights, certificates of
deposit, instruments and chattel paper and electronic chattel paper now owned or hereafter acquired
and Borrower’s Books relating to the foregoing; and

     All Borrower’s Books relating to the foregoing and any and all claims, rights and interests in any
of the above and all substitutions for, additions and accessions to and proceeds thereof.

     The Collateral shall not be deemed to include any copyrights, copyright applications, copyright
registration and like protection in each work of authorship and derivative work thereof, whether
published or unpublished, now owned or hereafter acquired; any patents, patent applications and
like protections including without limitation improvements, divisions, continuations, renewals,
reissues, extensions and continuations-in-part of the same, trademarks, servicemarks and
applications therefor, whether registered or not, and the goodwill of the business of Borrower
connected with and symbolized by such trademarks, any trade secret rights, including any rights to
unpatented inventions, know-how, operating manuals, license rights and agreements and confidential
information, now owned or hereafter acquired; or any claims for damage by way of any past, present
and future infringement of any of the foregoing (collectively, the “Intellectual Property”), except
that the Collateral shall include the proceeds of all the Intellectual Property including proceeds
from the sale, licensing or other disposition of the Intellectual Property and proceeds that are
accounts, (e.g., accounts receivable of Borrower, or general intangibles consisting of proceeds and
rights to payment). Notwithstanding the prior sentence, if a judicial authority (including a U.S.
Bankruptcy Court) holds that a security interest in the underlying
Intellectual Property is necessary to have a security interest in such accounts and general
intangibles of Borrower that are proceeds of the Intellectual Property, then the Collateral shall
automatically, and effective as of the Closing Date, include the Intellectual Property to the
extent necessary to permit perfection of Bank’s security interest in such accounts and general
intangibles of Borrower that are proceeds of the Intellectual Property.

 

 

LOAN MODIFICATION AGREEMENT

This Loan
Modification Agreement is entered into as of January 7, 2003, by and between Alexza
Molecular Delivery Corporation (the “Borrower”) and Silicon Valley Bank (“Bank”).

1.
DESCRIPTION OF EXISTING OBLIGATIONS: Among other Obligations which may be
owing by Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan
and Security Agreement, dated March 20, 2002, as may be amended from time to time (the “Loan
Agreement”). The Loan Agreement provides for, among other things, a Committed Equipment Line in the
original principal amount of One Million Dollars ($1,000,000). Defined terms used but not otherwise
defined herein shall have the same meanings as set forth in the Loan Agreement.

Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Obligations.”

2.
DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the
Collateral as described in the Loan Agreement.

Hereinafter, the above-described security documents and guaranties, together with all other
documents securing repayment of the Obligations shall be referred to as the “Security Documents”.
Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Obligations shall be referred to as the “Existing Loan Documents”.

3. DESCRIPTION OF CHANGE IN TERMS.

     A. Modification(s) to Loan Agreement.

	 	1.	 	The following Sections are hereby incorporated into the Loan Agreement:

2.1.2 Equipment 2 Facility.

(a) Subject to the terms and conditions of this Agreement, Bank agrees to lend to Borrower, from
time to time prior to the Commitment 2 Termination Date, equipment advances (each an “Equipment 2
Advance” and collectively the “Equipment 2 Advances”) in an aggregate amount not to exceed the
Committed Equipment 2 Line. When repaid, the Equipment 2 Advances may not be re-borrowed. The
proceeds of the Equipment 2 Advances will be used solely to reimburse Borrower for the purchase of
Eligible Equipment purchased within 90 days of the Equipment 2 Advance. Each Equipment 2 Advance
shall be considered a promissory note evidencing the amounts due hereunder for all purposes.
Bank’s obligation to lend hereunder shall terminate on the earlier of (i) the occurrence and
continuance of an Event of Default, or (ii) the Commitment 2 Termination Date. For purposes of
this Section, the minimum amount of each Equipment 2 Advance is $100,000 (with the exception of the
final Equipment 2 Advance which may be a lesser amount) and the maximum number of Equipment 2
Advances that will be made is 8.

(b) To obtain an Equipment 2 Advance, Borrower will deliver to Bank a completed supplement
in substantially the form attached as Exhibit D (“Loan 2 Supplement”) signed by a Responsible
Officer or his or her designee, copies of invoices for the Financed Equipment and such additional
information as Bank may request at least five (5) Business Days before the proposed funding date
(the “Funding Date”). On each Funding Date, Bank will specify in the Loan 2 Supplement for each
Equipment 2 Advance, the Basic Rate, the Loan Factor, and the Payment Dates. If Borrower
satisfies the conditions of each Equipment 2 Advance specified herein, Bank will disburse such
Equipment 2 Advance by

 

 

internal transfer to Borrower’s deposit account with Bank. Each Equipment 2 Advance may not exceed
100% of the Original Stated Cost. Notwithstanding the foregoing, Equipment 2 Advances used to
reimburse Borrower for the purchase of Eligible Equipment made beyond 90 days of the Equipment
Advance approved by Bank on a case by case basis shall be advanced at 100% of the net book value in
accordance with GAAP.

(c) Bank’s obligation to lend the undisbursed portion of the Committed Equipment 2 Line will
terminate if, in Bank’s sole discretion, there has been a material adverse change in the general
affairs, management, results of operation, condition (financial or otherwise) or the prospects of
Borrower, whether or not arising from transactions in the ordinary course of business, or there has
been any material adverse deviation by Borrower, in excess of 25%, from Borrower’s most recent cash
and operating forecast presented to and accepted by Bank prior to the execution of this Agreement.

2.2.2
Interest Rate, Payments Related to Equipment 2 Advances.

(a) Principal and Interest Payments On Payment Dates. Borrower will repay the Equipment 2
Advances on the terms provided in the Loan 2 Supplement. Borrower will make payments monthly in
advance of principal and accrued interest for each Equipment 2 Advance (collectively, “Scheduled
Payments”), on the first Business Day of the month following the Funding Date (or commencing on the
Funding Date if the Funding Date is the first Business Day of the month) with respect to such
Equipment 2 Advance and continuing thereafter during the Repayment Period on the first Business Day
of each calendar month (each a “Payment Date”), in an amount equal to the Loan Factor multiplied by
the Loan Amount for such Equipment 2 Advance as of such Payment Date. All unpaid principal and
accrued interest is due and payable in full on the last Payment Date with respect to such Equipment
2 Advance. Payments received after 12:00 noon Pacific time are considered received at the opening
of business on the next Business Day. An Equipment 2 Advance may only be prepaid in accordance with
Section 2.2.1(f).

(b) Interest Rate. Borrower will pay interest on the Payment Dates (as described above) at the
per annum rate of interest equal to the Basic Rate determined by Bank as of the Funding Date for
each Equipment 2 Advance in accordance with the definition of the Basic Rate, but no less than
5.75% per annum. Any amounts outstanding during the continuance of an Event of Default shall bear
interest at a per annum rate equal to the greater of either (i) Basic Rate plus five percentage
points or (ii) 10.75% per annum. If any change in the law increases Bank’s expenses or decreases
its return from the Equipment 2 Advances, Borrower will pay Bank upon request the amount of such
increase or decrease.

(c) Interim Payment. In addition to the Scheduled Payments, on the Funding Date for each
Equipment 2 Advance (unless the Funding Date is the first Business Day of the month) Borrower shall
pay to Bank, on behalf of Bank, an amount (the “Interim Payment”) equal to (i) the initial
Equipment 2 Advance multiplied by (ii) the Basic Rate, divided by (iii) 360 days and then
multiplied by (iv) the number of days from the actual Funding Date of the Equipment 2 Advance
until the first day of the month following such Equipment 2 Advance.

(d) Final Payment. On the Maturity Date with respect to each Equipment 2 Advance, Borrower
will pay, in addition to the unpaid principal and accrued interest and all other amounts due on
such date with respect to such Equipment 2 Advance, an amount equal to the Final Payment.

2

 

(e) Mandatory Prepayment Upon an Acceleration. If the Equipment 2 Advances are accelerated
following the occurrence of an Event of Default or otherwise, then Borrower will immediately pay to
Bank (i) all unpaid Scheduled Payments (including principal and interest) with respect to each
Equipment 2 Advance, (ii) all remaining Scheduled Payments (including principal and interest
unpaid) (iii) all accrued unpaid interest, including the default rate of interest, to the date of
the prepayment, (iv) the Final Payment and (v) all other sums, if any, that shall have become due
and payable with respect to any Equipment 2 Advance.

(f) Permitted Prepayment of Loans. Borrower shall have the option to prepay all, but not less than
all, of the Equipment 2 Advances advanced by Bank under this Agreement, provided Borrower
(i) provides written notice to Bank of its election to prepay the Equipment 2 Advances at least
thirty (30) days prior to such prepayment, and (ii) pays, on the date of the prepayment (A) all
accrued unpaid interest with respect to each Equipment 2 Advance to the date of prepayment; (B) all
outstanding principal with respect to each Equipment 2 Advance (C) the Final Payment; and (D) all
other sums, if any, that shall have become due and payable hereunder with respect to this
Agreement.

	 	2.	 	The following terms are hereby either amended in or incorporated into Section 13.1
entitled “Definitions”:

 “Basic Rate” is, as of the Funding Date, the per annum rate of interest (based on a year of 360
days) equal to the sum of (a) the Prime Rate on the day the Loan Supplement or Loan 2 Supplement is
prepared, plus (b) the Loan Margin; provided, however, the Basic Rate related to Equipment 2
Advances shall at no time be less than 5.75% per annum.

 “Commitment 2 Termination Date” is February 1, 2004.

 “Committed Equipment 2 Line” is a Credit Extension of up to $1,500,000.

 “Credit Extension” is each Equipment Advance, Equipment 2 Advance or any other extension of credit
by Bank for Borrower’s benefit.

 “Eligible Equipment” is general purpose computer equipment, office equipment, test and laboratory
equipment, furnishings, and, subject to the limitations set forth below, Other Equipment that
complies with all of Borrower’s representations and warranties to Bank and which is acceptable to
Bank in all respects. All Equipment financed with the proceeds of Equipment Advances or Equipment 2
Advances shall be new, provided that Bank, in its sole discretion, may finance used equipment.

 “Equipment 2 Advance” is defined in Section 2.1.2.

“Final Payment” is a payment (in addition to and not a substitution for the regular monthly
payments of principal plus accrued interest) due on the Maturity Date for such Equipment Advance or
Equipment 2 Advance equal to the Loan Amount for such Equipment Advance or Equipment 2 Advance
multiplied by the Final Payment Percentage.

 “Final Payment Percentage” is, for each Equipment Advance or Equipment 2 Advance, 6%.

3

 

“Financed Equipment” is, for each Equipment Advance, defined in the Loan Supplement, and, for each
Equipment 2 Advance, defined in the Loan 2 Supplement.

“Funding Date” is any date on which an Equipment Advance or Equipment 2 Advance is made to or on
account of Borrower.

“Loan Amount” is the aggregate amount of the Equipment Advance or the Equipment 2 Advance.

“Loan Factor” is the percentage which results from amortizing the Equipment Advance or the
Equipment 2 Advance over the Repayment Period, using the Basic Rate as the interest rate.

“Loan Margin” is 1.5 percentage points.

“Loan 2 Supplement” is attached as Exhibit D.

“Maturity Date” is, with respect to each Equipment Advance or Equipment 2 Advance, the last day of
the Repayment Period for such Equipment Advance or Equipment 2 Advance, or if earlier, the date of
acceleration of such Equipment Advance or Equipment 2 Advance by Bank following an Event of
Default.

“Original Stated Cost” is (i), the original cost to the Borrower of the item of new Eligible
Equipment or (ii) the fair market value assigned to such item of used Eligible Equipment by mutual
agreement of Borrower and Bank at the time of making of the Equipment Advance.

“Other Equipment” is leasehold improvements, intangible property such as computer software and
software licenses and other soft costs, including sales tax, freight and installation expense,
equipment specifically designed or manufactured for Borrower, other intangible property, limited
use property and other similar property. Unless otherwise agreed to by Bank: not more than 27% of
the Committed Equipment shall consist of Other Equipment and not more than 35% of the aggregate
Equipment 2 Advances shall consist of Other Equipment.

“Repayment
Period” as to the Equipment Advances or Equipment 2 Advances, is 48 months.

	 	3.	 	For valuable consideration, at such time as all Obligations under the Committed Equipment Line
are paid in full and the only Obligations outstanding are under the Committed Equipment 2 Line and
no Event of Default has occurred and is continuing, Bank shall release its security interest in all
Collateral except the specific Equipment financed under the Committed Equipment
2 Line together with all substitutions, renewals or replacements of and additions, improvements,
and accessions to any and all of the foregoing, and all proceeds from sales, renewals, releases or
other dispositions thereof. In addition, upon such event the Exhibit “A” to the Loan Agreement,
which describes the Collateral and any UCC financing statements related thereto, shall be amended
to read as the Exhibit “A” attached to this Loan Modification Agreement and shall include a
detailed description of the Equipment financed under the Committed Equipment 2 Line.

4.
CONSISTENT CHANGES. The Existing Loan Documents are hereby amended wherever
necessary to reflect the changes described above.

4

 

5. NO DEFENSES OF BORROWER. Borrower (and each guarantor and pledgor signing
below) agrees that, as of the date hereof, it has no defenses against paying any of the
Obligations.

6. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the
existing indebtedness, Bank is relying upon Borrower’s representations, warranties, and agreements,
as set forth in the Existing Loan Documents. Except as expressly modified pursuant to this Loan
Modification Agreement, the terms of the Existing Loan Documents remain unchanged and in full force
and effect. Bank’s agreement to modifications to the existing Obligations pursuant to this Loan
Modification Agreement in no way shall obligate Bank to make any future modifications to the
Obligations. Nothing in this Loan Modification Agreement shall constitute a satisfaction of the
Obligations. It is the intention of Bank and Borrower to retain as liable parties all makers and
endorsers of Existing Loan Documents, unless the party is expressly released by Bank in writing.
Unless expressly released herein, no maker, endorser, or guarantor will be released by virtue of
this Loan Modification Agreement. The terms of this paragraph apply not only to this Loan
Modification Agreement, but also to all subsequent loan modification agreements.

7. CONDITIONS. The effectiveness of this Loan Modification Agreement is
conditioned upon payment of the fees owed to Bank related to this Loan Modification Agreement and
Bank’s receipt of that certain Warrant agreement between Borrower and Bank.

     This Loan Modification Agreement is executed as of the date first written above.

	 	 	 	 	 	 	 	 	 
	BORROWER:	 	 	 	BANK:
	 
	 	 	 	 	 	 	 	 
	ALEXZA MOLECULAR DELIVERY CORPORATION	 	 	 	SILICON VALLEY BANK
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Carol A. Christopher
	 	 	 	By:
	 	/s/ Mercy Forde
	 

	 	 
	 	 	 	 	 	 
	Name:

	 	Carol A. Christopher
	 	 	 	Name:
	 	Mercy Forde
	Title:

	 	CFO
	 	 	 	Title:
	 	VP

5

 

EXHIBIT A

     The Collateral consists of all of Borrower’s right, title and interest in and to the following:

Each item of equipment, or personal property financed with an “Equipment 2 Advance” pursuant to
that certain Loan and Security Agreement, dated as of the Effective Date (as defined therein) (the
“Loan Agreement”), by and between Debtor and Secured Party, including, without limitation, the
property described in Annex A hereto, whether now owned or hereafter acquired, together with all
substitutions, renewals or replacements of and additions, improvements, and accessions to any and
all of the foregoing, and all proceeds from sales, renewals, releases or other dispositions
thereof.

 

 

EXHIBIT D

FORM OF LOAN AGREEMENT SUPPLEMENT

LOAN AGREEMENT SUPPLEMENT No. [ ]

FOR EQUIPMENT 2 ADVANCES

     LOAN
AGREEMENT SUPPLEMENT No. [ ], dated                    , 200___(“Supplement”), to the Loan and Security Agreement dated as of March 20, 2002 (the “Loan Agreement) by and between the
undersigned (“Borrower”), and Silicon Valley Bank (“Bank”).

     Capitalized terms used herein but not otherwise defined herein are used with the respective
meanings given to such terms in the Loan Agreement.

To secure the prompt payment by Borrower of all amounts from time to time outstanding under the
Loan Agreement, and the performance by Borrower of all the terms contained in the Loan Agreement,
Borrower grants Bank, a first priority security interest in each item of equipment and other
property described in Annex A hereto, which equipment and other property shall be deemed to be
additional Financed Equipment and Collateral. The Loan Agreement is hereby incorporated by
reference herein and is hereby ratified, approved and confirmed.

Annex A (Equipment Schedule) and Annex B (Loan Terms Schedule) are attached hereto.

The proceeds of the Loan should be transferred to Borrower’s account with Bank set forth below:

Bank Name:     Silicon Valley Bank

Account No.:                                   

Borrower hereby certifies that (a) the foregoing information is true and correct and authorizes
Bank to endorse in its respective books and records, the Basic Rate applicable to the Funding Date
of the Loan contemplated in this Loan Agreement Supplement and the principal amount set forth in
the Loan Terms Schedule; (b) the representations and warranties made by Borrower in the Loan
Agreement are true and correct on the date hereof and will be true and correct on such Funding
Date. No Event of Default has occurred and is continuing under the Loan Agreement.
This Supplement may be executed by Borrower and Bank in separate counterparts, each of which when
so executed and delivered shall be an original, but all such counterparts shall together constitute
but one and the same instrument.

     This Supplement is delivered as of this day and year first above written.

	 	 	 	 	 	 	 	 	 	 	 
	SILICON VALLEY BANK	 	ALEXZA MOLECULAR DELIVERY CORPORATION
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	 	 	 	 	By:	 	 	 	 
	 	 	 	 	 	 	 
	 

	 	Name:
	 	 	 	 	 	Name:	 	 
	 

	 	 	 	 
	 	 	 	 	 	 
	 

	 	Title:
	 	 	 	 	 	Title:	 	 
	 

	 	 	 	 
	 	 	 	 	 	 

Annex A
– Description of Financed Equipment

Annex B
– Loan Terms Schedule

 

 

Annex A to Exhibit D

     The Financed Equipment being financed with the Equipment 2 Advance which this Loan Agreement
Supplement is being executed is listed below. Upon the funding of such Equipment 2 Advance, this
schedule automatically shall be deemed to be a part of the Collateral.

	 	 	 	 	 	 	 	 	 
	of Equipment:

	 	Make
	 	Model
	 	Serial #
	 	Invoice #

2

 

Annex B to Exhibit D

LOAN TERMS SCHEDULE #                    

Loan Funding Date:                     , 200_

Original Loan Amount: $                    

Basic Rate:                     %

Loan Factor:                    %

Scheduled Payment Dates and Amounts*:

One
(1) payment of $                    
due                                        

          
    payment of $                    
due monthly in advance from                     through                    .

One (1) payment of $                     due                                        

Maturity Date:                     

			
	Final Payment:	 	An additional amount equal to the Final Payment Percentage multiplied by the Loan
Amount then in effect, shall be paid on the Maturity Date with respect to such Loan.

	 	 	 	 	 
	Payment No.	 	Payment Date	 
	1
	 	 	 	 
	2
	 	 	 	 
	3
	 	 	 	 
	4
	 	 	 	 
	...
	 	 	 	 
	47
	 	 	 	 
	[48]
	 	 	 	 
	...
	 	 	 	 

 

			
	*/	 	The amount of each Scheduled Payment will change as the Loan Amount changes.

3

 

LOAN MODIFICATION AGREEMENT

This Loan Modification Agreement is entered into as of September 3, 2003, by and between
Alexza Molecular Delivery Corporation (the “Borrower”) and Silicon Valley Bank (“Bank”).

1. DESCRIPTION OF EXISTING OBLIGATIONS: Among other Obligations which may be owing
by Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan and
Security Agreement, dated March 20, 2002, as amended or modified from time to time, (the “Loan
Agreement”). The Loan Agreement provides for, among other things, a Committed Equipment Line in the
original principal amount of One Million Dollars ($1,000,000). The Loan Agreement has been modified
pursuant to, among other documents, a Loan Modification Agreement dated January 3, 2003, pursuant
to which, among other things, a Committed Equipment 2 Line was incorporated in the original
principal amount of One Million Five Hundred Thousand Dollars ($1,500,000). Defined terms used but
not otherwise defined herein shall have the same meanings as set forth in the Loan Agreement.

Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Obligations.”

2. DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the
Collateral as described in the Loan Agreement.

Hereinafter, the above-described security documents and guaranties, together with all other
documents securing repayment of the Obligations shall be referred to as the “Security Documents”.
Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Obligations shall be referred to as the “Existing Loan Documents”.

3. DESCRIPTION OF CHANGE IN TERMS. 

     A. Modification(s) to Loan Agreement.

          1. The following defined terms under Section 13.1 entitled “Definitions” are hereby amended
to read as follows:

“Commitment 2 Termination Date” is March 31, 2004.

“Committed Equipment 2 Line” is a Credit Extension of up to $2,700,000.

4. CONSISTENT CHANGES. The Existing Loan Documents are hereby amended
wherever necessary to reflect the changes described above.

5. NO DEFENSES OF BORROWER. Borrower (and each guarantor and pledger signing
below) agrees that, as of the date hereof, it has no defenses against paying any of the
Obligations.

6. CONTINUING VALIDITY. Borrower (and each guarantor and pledgor signing below)
understands and agrees that in modifying the existing Indebtedness, Bank is relying upon Borrower’s
representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except
as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan
Documents remain unchanged and in full force and effect. Bank’s agreement to modifications to the
existing Obligations pursuant to this Loan Modification Agreement in no way shall obligate Bank to
make any future modifications to the Obligations. Nothing in this Loan Modification Agreement shall
constitute a satisfaction of the Obligations. It is the intention of Bank and Borrower to retain as
liable parties all makers and endorsers of Existing Loan Documents, unless the party is expressly
released by Bank in writing. Unless expressly released herein, no maker, endorser, or guarantor
will be released by virtue of this Loan Modification Agreement. The terms of this paragraph apply
not only to this Loan Modification Agreement, but also to all subsequent loan modification
agreements.

 

 

     This Loan Modification Agreement is executed as of the date first written above.

	 	 	 	 	 	 	 	 	 
	BORROWER:	 	 	 	BANK:
	 
	 	 	 	 	 	 	 	 
	ALEXZA MOLECULAR DELIVERY CORPORATION	 	 	 	SILICON VALLEY BANK
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Carol A. Christopher
	 	 	 	By:
	 	/s/ Mercy Forde
	 

	 	 
	 	 	 	 	 	 
	Name:

	 	Carol A. Christopher
	 	 	 	Name:
	 	Mercy Forde
	Title:

	 	CFO and VP, Business Development
	 	 	 	Title:
	 	 Vice President

 

 

LOAN MODIFICATION AGREEMENT

This Loan Modification Agreement is entered into as of March 18, 2004 by and between Alexza
Molecular Delivery Corporation (the “Borrower”) and Silicon Valley Bank (“Bank”).

1. DESCRIPTION OF EXISTING OBLIGATIONS: Among other Obligations which may be owing by
Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan and
Security Agreement, dated March 20, 2002, as amended or modified from time to time (the “Loan
Agreement). The Loan Agreement provides for, among other things, a Committed Equipment Line in the
original principal amount of One Million Dollars ($1,000,000). The Loan Agreement has been modified
pursuant to, among other documents, a Loan Modification Agreement dated January 7, 2003, pursuant
to which, among other things, a Committed Equipment Line 2 was incorporated in the original
principal amount of One Million Five Hundred Thousand Dollars ($1,500,000). The Loan Agreement has
been further modified pursuant to, among other documents, a Loan Modification Agreement dated
September 3, 2003, pursuant to which, among other things, a Committed Equipment 2 Line was
increased to Two Million Seven Hundred Thousand Dollars ($2,700,000). Defined terms used but not
otherwise defined herein shall have the same meanings as set forth in the Loan Agreement.

Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Obligations.”

2. DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the
Collateral as described in the Loan Agreement.

Hereinafter, the above-described security documents and guaranties, together with all other
documents securing repayment of the Obligations shall be referred to as the “Security Documents”.
Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Obligations shall be referred to as the “Existing Loan Documents”.

3. DESCRIPTION OF CHANGE IN TERMS. 

     A. Modification(s) to Loan Agreement.

          1. The following defined terms under Section 13.1 entitled “Definitions” are hereby amended
to read as follows:

“Committed
2 Termination Date” is December 31, 2004.

“Committed Equipment 2 Line” is a Credit Extension of up to $3,200,000.

4. CONSISTENT CHANGES. The Existing Loan Documents are hereby amended wherever
necessary to reflect the changes described above.

5. NO DEFENSES OF BORROWER. Borrower (and each guarantor and pledgor signing
below) agrees that, as of the date hereof, it has no defenses against paying any of the
Obligations.

6. CONTINUING VALIDITY. Borrower (and each guarantor and pledger signing below)
understands and agrees that in modifying the existing Indebtedness, Bank is relying upon Borrower’s
representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except
as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan
Documents remain unchanged and in full force and effect. Bank’s agreement to modifications to the
existing Obligations pursuant to this Loan Modification Agreement in no way shall obligate Bank to
make any future modifications to the Obligations. Nothing in this Loan Modification Agreement shall
constitute a satisfaction of the Obligations. It is the intention of Bank and Borrower to retain as
liable parties all makers and endorsers of Existing Loan Documents, unless the party is expressly
released by Bank in writing. Unless expressly released herein, no

 

 

maker, endorser, or guarantor will be released by virtue of this Loan Modification Agreement. The
terms of this paragraph apply not only to this Loan Modification Agreement, but also to all
subsequent loan modification agreements.

     This Loan Modification Agreement is executed as of the date first written above.

	 	 	 	 	 	 	 	 	 
	BORROWER:	 	 	 	BANK:
	 
	 	 	 	 	 	 	 	 
	ALEXZA MOLECULAR DELIVERY CORPORATION	 	 	 	SILICON VALLEY BANK
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/ Thomas B. King
	 	 	 	By:	 	 
	 

	 	 
	 	 	 	 	 	 
	Name:

	 	Thomas B. King
	 	 	 	Name:	 	 
	 

	 	 	 	 	 	 	 	 
	Title:

	 	President & CEO
	 	 	 	Title:	 	 
	 

	 	 	 	 	 	 	 	 

 

 

LOAN MODIFICATION AGREEMENT

This Loan Modification Agreement is entered into as of May 16, 2005, by and between Alexza
Molecular Delivery Corporation (the “Borrower”) and Silicon
Valley Bank (“Bank”).

1. DESCRIPTION OF EXISTING OBLIGATIONS: Among other Obligations which may be
owing by Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan
and Security Agreement, dated March 20, 2002 (as may be amended, restated, or otherwise modified
from time to time, the “Loan Agreement”). The Loan Agreement provides for, among other things, a
Committed Equipment Line in the original principal amount of One Million Dollars ($1,000,000). The
Loan Agreement has been modified pursuant to, among other documents, a Loan Modification Agreement
dated January 7, 2003, pursuant to which, among other things, the Committed Equipment 2 Line was
incorporated in the original principal amount of One Million Five Hundred Thousand Dollars
($1,500,000). The Loan Agreement has been further modified pursuant to which, among other things,
the Committed Equipment 2 Line was increased to Three Million Two Hundred Thousand Dollars
($3,200,000). Defined terms used but not otherwise defined herein shall have the same meanings as
set forth in the Loan Agreement.

Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Obligations.”

2. DESCRIPTION OF COLLATERAL. Repayment of the Obligations is secured by the
Collateral as described in the Loan Agreement.

Hereinafter, the above-described security documents and guaranties, together with all other
documents securing repayment of the Obligations shall be referred to as the “Security Documents”.
Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Obligations shall be referred to as the “Existing Loan Documents”.

3. DESCRIPTION OF CHANGE IN TERMS. 

     A. Modification(s) to Loan Agreement.

	 	1.	 	Section 2.1.3 entitled “Equipment Facility” is hereby incorporated to read as follows:

	 	(a)	 	Bank will make a Term Loan available to Borrower.
	 
	 	(b)	 	Borrower will pay 48 equal installments of principal and interest (the “Term Loan
Payment”). Each Term Loan Payment is payable on the 1st of each month during the term of the loan.
Borrower’s final Term Loan Payment, due on Term Loan Maturity Date, includes all outstanding Term
Loan principal and accrued interest.
	 
	 	(c)	 	Bank’s obligation to lend the undisbursed portion of the Obligations will terminate if,
in Bank’s sole discretion, there has been a material adverse change in the general affairs,
management, results of operation, condition (financial or otherwise) or the prospect of
repayment of the Obligations, or there has been any material adverse deviation by Borrower from
the most recent business plan of Borrower presented to and accepted by Bank prior to the execution
of this Agreement.

	 	2.	 	Section 2.2.3 entitled “Interest Rate, Payments” is hereby amended in its entirety to
read as follows:

     (a) Interest Rate. The Term Loan accrues interest at a fixed rate per annum rate equal to the
greater of the (i) Basic Rate or (ii) 7.25%. After an Event of Default, Obligations accrue interest
at 5 percent above the rate effective

 

 

immediately before the Event of Default. Interest is computed on a 360 day year for the actual
number of days elapsed.

     (b) Payments. Bank may debit any of Borrower’s deposit accounts including Account Number
3300361898 for principal and interest payments owing or any amounts Borrower owes Bank.
Bank will promptly notify Borrower when it debits Borrower’s accounts. These debits are not a
set-off. Payments received after 12:00 noon Pacific time are considered received at the opening of
business on the next Business Day. When a payment is due on a day that is not a Business Day, the
payment is due the next Business Day and additional interest shall accrue.

	 	3.	 	Section 2.4 entitled “Additional Costs” is hereby incorporated to read as follows:

If any law or regulation increases Bank’s costs or reduces its income for any loan, Borrower will
pay the increase in cost or reduction in income or additional expense.

	 	4.	 	The following defined terms under Section 13.1 entitled “Definitions” is hereby amended
and/or incorporated to read as follows:

“Basic Rate” is, as of the date the Term Loan is made, the per annum rate of interest (based on a
year of 360 days) equal to the sum of (a) the U.S. Treasury note yield to maturity for a term equal
to the Treasury Note Maturity as quoted in The Wall Street Journal on the day the Term Loan is
made, plus (b) the Loan Margin.

“Credit Extension” is each Term Loan or any other extension of credit by Bank for Borrower’s
benefit.

“Loan Margin” is 3.50 basis points.

“Term
Loan” is a loan of up to $ 2,714,459,39.

“Term Loan Maturity Date” is May 1, 2009.

“Treasury Note Maturity” is 36 months.

	 	5.	 	For valuable consideration, at such time as all Obligations under the Committed Equipment
Line and Committed Equipment 2 Line are paid in full and the only Obligation outstanding is the
Term Loan and no Event of Default has occurred and is continuing, Bank shall release its security
interest in all Collateral except Bank will continue to have a security interest in all of the
specific equipment which was financed by Bank including such equipment under the Committed
Equipment Line and Committed Equipment 2 Line together will all substitutions, renewals or
replacements of and additions, improvements, and accessions to any and all of the foregoing, and
all proceeds from sales, renewals, releases other dispositions hereof.

     B. Waiver of Financial Covenant Default(s)

	 	1.	 	Bank hereby waives Borrower’s existing default under the Loan Agreement by virtue of Borrower’s
failure to deliver its 2004 audited financial statements within 120 days after Borrower’s fiscal
year ended December 31, 2004. Bank’s waiver of Borrower’s compliance of this covenant shall apply
only to the foregoing period. Accordingly, Borrower shall deliver such audited financial statement
on or prior to July 31, 2005 and Borrower shall be in compliance with this covenant for the year
ending December 31, 2005 and thereafter.

 

 

Bank’s agreement to waive the above-described default (1) in no way shall be deemed an
agreement by the Bank to waive Borrower’s compliance with the
above-described covenant as of all
other dates and (2) shall not limit or impair the Bank’s right to demand strict performance of this
covenant as of all other dates and (3) shall not limit or impair the Bank’s right to demand strict
performance of all other covenants as of any date.

4.
CONSISTENT CHANGES. The Existing Loan Documents are hereby amended
wherever necessary to reflect the changes described above.

5. NO
DEFENSES OF BORROWER. Borrower (and each guarantor and pledgor signing
below) agrees that, as of the date hereof, it has no defenses against paying any of the
Obligations.

6.
CONTINUING VALIDITY. Borrower (and each guarantor and pledgor signing below)
understands and agrees that in modifying the existing indebtedness, Bank is relying upon Borrower’s
representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except
as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan
Documents remain unchanged and in full force and effect. Bank’s agreement to modifications to the
existing Obligations pursuant to this Loan Modification Agreement in no way shall obligate Bank to
make any future modifications to the Obligations. Nothing in this Loan Modification Agreement shall
constitute a satisfaction of the Obligations. It is the intention of Bank and Borrower to retain as
liable parties all makers and endorsers of Existing Loan Documents, unless the party is expressly
released by Bank in writing. Unless expressly released herein, no maker, endorser, or guarantor
will be released by virtue of this Loan Modification Agreement. The terms of this paragraph apply
not only to this Loan Modification Agreement, but also to all subsequent loan modification
agreements.

7.
CONDITION. The proceeds of the Term Loan shall be used to pay in full
Borrower’s existing outstanding Loans with Bank

     This Loan Modification Agreement is executed as of the date first written above.

	 	 	 	 	 	 	 	 	 
	BORROWER:	 	 	 	BANK:
	 
	 	 	 	 	 	 	 	 
	ALEXZA MOLECULAR DELIVERY CORPORATION	 	 	 	SILICON VALLEY BANK
	 
	 	 	 	 	 	 	 	 
	By:

	 	/s/August J. Moretti
	 	 	 	By:
	 	/s/ Christopher Wagner
	 

	 	 
	 	 	 	 	 	 
	Name:

	 	August J. Moretti
	 	 	 	Name:
	 	Christopher Wagner
	Title:

	 	CFO
	 	 	 	Title:
	 	Sr Rel Mgrexv10w15

 

Exhibit
10.15

MASTER
SECURITY AGREEMENT

dated as of May 17, 2005 (“Agreement”)

     THIS AGREEMENT is between General Electric Capital Corporation (together with its successors and
assigns, if any, “Secured Party”) and Alexza
Molecular Delivery Corporation (“Debtor”). Secured
Party has an office at 83 Wooster Heights Road, Danbury, CT 06810. Debtor is a corporation
organized and existing under the laws of the state of DE
(“the State”). Debtor’s mailing address
and chief place of business is 1001 East Meadow Circle, Palo Alto, CA 94303.

	1.	 	CREATION OF SECURITY INTEREST.

     Debtor grants to Secured Party, its successors and assigns a security interest in and
against all property listed on any collateral schedule now or in the future annexed to or made a
part of this Agreement (“Collateral Schedule”), and in and against all additions, attachments,
accessories and accessions to such property, all substitutions, replacements or exchanges
therefor, and all insurance and/or other proceeds thereof (all such property is individually and
collectively called the “Collateral”). This security interest is given to secure the payment and
performance of all debts, obligations and liabilities of any kind whatsoever of Debtor to Secured
Party, now existing or arising in the future, including but not limited to the payment and
performance of certain Promissory Notes from time to time identified on any Collateral Schedule
(collectively “Notes” and each a
“Note”), and any renewals, extensions and modifications of such
debts, obligations and liabilities (such Notes, debts, obligations and liabilities are called the
“Indebtedness”).

	2.	 	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR.

     Debtor represents, warrants and covenants as of the date of this Agreement and as of the date
of each Collateral Schedule that:

     (a) Debtor’s exact legal name is as set forth in the preamble of this Agreement and Debtor is,
and will remain, duly organized, existing and in good standing under
the laws of the State set
forth in the preamble of this Agreement, has its chief executive offices at the location specified
in the preamble, and is, and will remain, duly qualified and licensed in every jurisdiction
wherever necessary to carry on its business and operations;

     (b) Debtor has adequate power and capacity to enter into, and to perform its obligations under
this Agreement, each Note and any other documents evidencing, or given in connection with, any of
the Indebtedness (all of the foregoing are called the “Debt Documents”);

     (c) This Agreement and the other Debt Documents have been duly authorized, executed and
delivered by Debtor and constitute legal, valid and binding agreements enforceable in accordance
with their terms, except to the extent that the enforcement of remedies may be limited under
applicable bankruptcy and insolvency laws;

     (d) No approval, consent or withholding of objections is required from any governmental
authority or instrumentality with respect to the entry into, or performance by Debtor of any of the
Debt Documents, except any already obtained;

     (e) The
entry into, and performance by, Debtor of the Debt Documents will not (i) violate
any of the organizational documents of Debtor or any judgment, order, law or regulation
applicable to Debtor, or (ii) result in any breach of or constitute a default under any contract
to which Debtor is a party, or result in the creation of any lien, claim or encumbrance on any of
Debtor’s property (except for liens in favor of Secured Party)
pursuant to any indenture,
mortgage, deed of trust, bank loan, credit agreement, or other agreement or instrument to which
Debtor is a party;

     (f) There are no suits or proceedings pending in court or before any commission, board or
other administrative agency against or affecting Debtor which could, in the aggregate, have a
material adverse effect on Debtor, its business or operations, or its ability to perform its
obligations under the Debt Documents, nor does Debtor have reason to believe that any such suits or
proceedings arc threatened;

     (g) All financial statements delivered to Secured Party in connection with the Indebtedness
have been prepared in accordance with generally accepted accounting principles, and since the date
of the most recent financial statement, there has been no material adverse change in Debtors
financial condition;

     (h) The Collateral is not, and will not be, used by Debtor for personal, family or household
purposes;

     (i) The Collateral is, and will remain, in good condition and repair and Debtor will not be
negligent in its care and use;

     (j) Debtor is, and will remain, the sole and lawful owner, and in possession of, the
Collateral, and has the sole right and lawful authority to grant the security interest described
in this Agreement;

 

 

     (k) The Collateral is, and will remain, free and clear of all liens, claims and encumbrances
of any kind whatsoever, except for (i) liens in favor of Secured
Party, (ii) liens for taxes not
yet due or for taxes being contested in good faith and which do not involve, in the judgment of
Secured Party, any risk of the sale, forfeiture or loss of any of the Collateral, and (iii)
inchoate materialmen’s, mechanic’s, repairmen’s and similar liens arising by operation of law in
the normal course of business for amounts which are not delinquent (all of such liens are called
“Permitted Liens”);

     (1) Debtor is and will remain in full compliance with all laws and regulations applicable to
it including, without limitation, (i) ensuring that no person who owns a controlling interest in
or otherwise controls Debtor is or shall be (Y) listed on the Specially Designated Nationals and
Blocked Person List maintained by the Office of Foreign Assets
Control (“OFAC”), Department of
the Treasury, and/or any other similar lists maintained by OFAC pursuant to any authorizing
statute, Executive Order or regulation or (Z) a person designated under Section l(b), (c) or (d)
of Executive Order No. 13224 (September 23, 2001), any related enabling legislation or any other
similar Executive Orders, and (ii) compliance with all applicable Bank Secrecy Act (“BSA”) laws,
regulations and government guidance on BSA compliance and on the prevention and detection of
money laundering violations; and

	3.	 	COLLATERAL.

     (a) Until the declaration of any default, Debtor shall remain in possession of the Collateral;
except that Secured Party shall have the right to possess (i) any chattel paper or instrument that
constitutes a part of the Collateral, and (ii) any other Collateral in which Secured Party’s
security interest may be perfected only by possession. Secured Party may inspect any of the
Collateral during normal business hours after giving Debtor reasonable prior notice. If Secured
Party asks, Debtor will promptly notify Secured Party in writing of the location of any Collateral.

     (b) Debtor shall (i) use the Collateral only in its trade or business, (ii) maintain all of
the Collateral in good operating order and repair, normal wear and tear excepted, (iii) use and
maintain the Collateral only in compliance with manufacturers recommendations and all applicable
laws, and (iv) keep all of the Collateral free and clear of all liens, claims and encumbrances
(except for Permitted Liens).

     (c) Secured
Party does not authorize and Debtor agrees it shall not (i) part with possession
of any of the Collateral (except to Secured Party or for maintenance and repair), (ii) remove any
of the Collateral from the continental United States, or (iii) sell, rent, lease, mortgage,
license, grant a security interest in or otherwise transfer or encumber (except for Permitted
Liens) any of the Collateral.

     (d) Debtor shall pay promptly when due all taxes, license fees, assessments and public and
private charges levied or assessed on any of the Collateral, on its use, or on this Agreement or
any of the other Debt Documents. At its option, Secured Party may discharge taxes, liens, security
interests or other encumbrances at any time levied or placed on the Collateral and may pay for the
maintenance, insurance and preservation of the Collateral and effect compliance with the terms of
this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on
demand, all costs and expenses incurred by Secured Party in connection with such payment or
performance and agrees that such reimbursement obligation shall constitute Indebtedness.

     (e) Debtor shall, at all times, keep accurate and complete records of the Collateral, and
Secured Party shall have the right to inspect and make copies of all of Debtor’s books and records
relating to the Collateral during normal business hours, after giving Debtor reasonable prior
notice.

     (f) Debtor
agrees and acknowledges that any third person who may at any time possess all or
any portion of the Collateral shall be deemed to hold, and shall hold, the Collateral as the agent
of, and as pledge holder for, Secured Party. Secured Party may at any time give notice to any third
person described in the preceding sentence that such third person is holding the Collateral as the
agent of, and as pledge holder for, the Secured Party.

	4.	 	INSURANCE.

     (a) Debtor shall at all times bear the entire risk of any loss, theft, damage to, or
destruction of, any of the Collateral from any cause whatsoever.

     (b) Debtor agrees to keep the Collateral insured against loss or damage by fire and extended
coverage perils, theft, burglary, and for any or all Collateral which are vehicles, for risk of
loss by collision, and if requested by Secured Party, against such other risks as Secured Party may
reasonably require. The insurance coverage shall be in an amount no less than the full replacement
value of the Collateral, and deductible amounts, insurers and policies shall be acceptable to
Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance
evidencing such coverage. Each policy shall name Secured Party as a loss payee, shall provide for
coverage to Secured Party regardless of the breach by Debtor of any warranty or representation made
therein, shall not be subject to co-insurance, and shall provide that coverage may not be canceled
or altered by the insurer except upon thirty (30) days prior written notice to Secured Party.
Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance
and adjustments with insurers, and to receive payment of and execute or endorse all documents,
checks or drafts in connection with insurance payments. Secured Party shall not act as Debtor’s
attorney-in-fact unless Debtor is in default. Proceeds of insurance shall be applied, at the option
of Secured Party, to repair or replace the Collateral or to reduce any of the Indebtedness.

	5.	 	REPORTS.

 

 

     (a) Debtor shall promptly notify Secured Party of (i) any change in the name of Debtor, (ii)
any change in the state of its incorporation, organization or registration, (iii) any relocation
of its chief executive offices, (iv) any relocation of any of the Collateral, (v) any of the
Collateral being lost, stolen, missing, destroyed, materially damaged
or worn out, or (vi) any
lien, claim or encumbrance other than Permitted Liens attaching to or being made against any of
the Collateral.

     (b) Debtor will deliver to Secured Party financial statements as follows. If Debtor is a
privately held company, then Debtor agrees to provide quarterly financial statements, certified by
Debtor’s president or chief financial officer including a balance sheet, statement of operations
and cash flow statement within 45 days of each quarter end and its complete audited annual
financial statements, certified by a recognized firm of certified public accountants, within 120
days of fiscal year end or at such time as Debtor’s Board of
Directors receives the audit. If
Debtor is a publicly held company, then Debtor agrees to provide quarterly unaudited statements
and annual audited statements, certified by a recognized firm of certified public accountants,
within 10 days after the statements are provided to the Securities and Exchange Commission
(“SEC”). All such statements are to be prepared using generally accepted accounting principles
(“GAAP”) and, if Debtor is a publicly held company, are to be in compliance with SEC requirements.

	6.	 	FURTHER ASSURANCES.

     (a) Debtor shall, upon request of Secured Party, furnish to Secured Party such further
information, execute and deliver to Secured Party such documents and instruments (including,
without limitation, Uniform Commercial Code financing statements) and shall do such other acts and
things as Secured Party may at any time reasonably request relating to the perfection or protection
of the security interest created by this Agreement or for the purpose of carrying out the intent of
this Agreement. Without limiting the foregoing, Debtor shall cooperate and do all acts deemed
necessary or advisable by Secured Party to continue in Secured Party a perfected first security
interest in the Collateral, and shall obtain and furnish to Secured Party any subordinations,
releases, landlord waivers, lessor waivers, mortgagee waivers, or control agreements, and similar
documents as may be from time to time requested by, and in form and substance satisfactory to,
Secured Party.

     (b) Debtor authorizes Secured Party to file a financing statement and amendments thereto
describing the Collateral and containing any other information required by the applicable Uniform
Commercial Code. Debtor irrevocably grants to Secured Party the power to sign Debtor’s name and
generally to act on behalf of Debtor to execute and file applications for title, transfers of
title, financing statements, notices of lien and other documents pertaining to any or all of the
Collateral; this power is coupled with Secured Party’s interest in the Collateral. Debtor shall, if
any certificate of title be required or permitted by law for any of the Collateral, obtain and
promptly deliver to Secured Party such certificate showing the lien of this Agreement with respect
to the Collateral. Debtor ratifies its prior authorization for Secured Party to file financing
statements and amendments thereto describing the Collateral and containing any other information
required by the Uniform Commercial Code if filed prior to the date hereof.

     (c) Debtor shall indemnify and defend the Secured Party, its successors and assigns, and their
respective directors, officers and employees, from and against all claims, actions and suits
(including, without limitation, related attorneys’ fees) of any kind whatsoever arising, directly
or indirectly, in connection with any of the Collateral.

	7.	 	DEFAULT AND REMEDIES.

     (a) Debtor shall be in default under this Agreement and each of the other Debt Documents if:

          (i) Debtor breaches its obligation to pay when due any installment or other amount due or
coming due under any of the Debt Documents and fails to cure the breach within ten (10) days;

          (ii) Debtor, without the prior written consent of Secured Party, attempts to or does sell,
rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or encumber
(except for Permitted Liens) any of the Collateral;

          (iii) Debtor breaches any of its insurance obligations under Section 4;

          (iv) Debtor
breaches any of its other obligations under any of the Debt Documents and fails
to cure that breach within thirty (30) days after written notice from Secured Party;

          (v) Any warranty, representation or statement made by Debtor in any of the Debt Documents or
otherwise in connection with any of the Indebtedness shall be false or misleading in any material
respect;

          (vi) Any of the Collateral is subjected to attachment, execution, levy, seizure or
confiscation in any legal proceeding or otherwise, or if any legal or administrative proceeding
is commenced against Debtor or any of the Collateral, which in the good faith judgment of Secured
Party subjects any of the Collateral to a material risk of attachment, execution, levy, seizure
or confiscation and no bond is posted or protective order obtained to negate such risk;

          (vii) Debtor breaches or is in default under any other agreement between Debtor and Secured
Party;

 

 

          (viii) Debtor
or any guarantor or other obligor for any of the Indebtedness (collectively
“Guarantor”) dissolves, terminates its existence, becomes insolvent or ceases to do business as a
going concern;

          (ix) If Debtor or any Guarantor is a natural person, Debtor or any such Guarantor dies or
becomes incompetent;

          (x) A receiver is appointed for all or of any part of the property of Debtor or any
Guarantor, or Debtor or any Guarantor makes any assignment for the benefit of creditors;

          (xi) Debtor or any Guarantor files a petition under any bankruptcy, insolvency or
similar law, or any such petition is filed against Debtor or any Guarantor and is not
dismissed within forty-five (45) days;

          (xii) Debtor’s improper filing of an amendment or termination statement relating to a filed
financing statement describing the Collateral;

          (xiii) There is a material adverse change in the Debtor’s financial condition as
determined solely by Secured Parry. It being understood that Debtor’s business plan calls for
continuing losses and a need for additional cash on or about December 31, 2006, and such
financial performance will not be deemed to be a material adverse change in Debtor’s
financial condition;

          (xiv) Any Guarantor revokes or attempts to revoke its guaranty of any of the Indebtedness
or fails to observe or perform any covenant, condition or agreement to be performed under any
guaranty or other related document to which it is a party;

          (xv) Debtor defaults under any other material obligation for (A) borrowed money, (B) the
deferred purchase price of property or (C) payments due under any lease agreement;

          (xvi) At any time during the term of this Agreement Debtor sells more than 50% of its
interest in the company to another corporation or business or all or substantially all of its
assets without Secured Party’s prior written consent; or

     (b) If
Debtor is in default, the Secured Party, at its option, may declare any or all of the
Indebtedness to be immediately due and payable, without demand or notice to Debtor or any
Guarantor. The accelerated obligations and liabilities shall bear interest (both before and after
any judgment) until paid in full at the lower of eighteen percent (18%) per annum or the maximum
rate not prohibited by applicable law.

     (c) After
default, Secured Party shall have all of the rights and remedies of a
Secured Party
under the Uniform Commercial Code, and under any other applicable law. Without limiting the
foregoing, Secured Party shall have the right to (i) notify any account debtor of Debtor or any
obligor on any instrument which constitutes part of the Collateral to make payment to the Secured
Party, (ii) with or without legal process, enter any premises where the Collateral may be and take
possession of and remove the Collateral from the premises or store it on the premises, (iii) sell
the Collateral at public or private sale, in whole or in part, and have the right to bid and
purchase at said sale, or (iv) lease or otherwise dispose of all or part of the Collateral,
applying proceeds from such disposition to the obligations then in default. If requested by
Secured Party, Debtor shall promptly assemble the Collateral and make it available to Secured Party
at a place to be designated by Secured Party which is reasonably convenient to both parties.
Secured Party may also render any or all of the Collateral unusable at the Debtor’s premises and
may dispose of such Collateral on such premises without liability for real or costs. Any notice
that Secured Party is required to give to Debtor under the Uniform Commercial Code of the time and
place of any public sale or the time after which any private sale or other intended disposition of
the Collateral is to be made shall be deemed to constitute reasonable notice if such notice is
given to the last known address of Debtor at least five (5) days prior to such action.

     (d) Proceeds, from any sale or lease or other disposition shall be applied: first, to all
costs of repossession, storage, and disposition including without limitation attorneys’,
appraisers’, and auctioneers’ fees; second, to discharge the obligations then in default; third,
to discharge any other Indebtedness of Debtor to Secured Party, whether as obligor, endorser,
guarantor, surety or indemnitor, fourth, to expenses incurred in paying or settling liens and
claims against the Collateral; and lastly, to Debtor, if there exists any surplus. Debtor shall
remain fully liable for any deficiency.

     (e) Debtor agrees to pay all reasonable attorneys’ fees and other costs incurred by Secured
Party in connection with the enforcement, assertion, defense or preservation of Secured Party’s
rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be
permitted. Debtor further agrees that such fees and costs shall constitute Indebtedness.

     (f) Secured
Party’s rights and remedies under this Agreement or otherwise arising are
cumulative and may be exercised singularly or concurrently. Neither the failure nor any delay on
the part of the Secured Party to exercise any right, power or privilege under this Agreement shall
operate as a waiver, nor shall any single or partial exercise of any right, power or privilege
preclude any other or further exercise of that or any other right, power or privilege. SECURED
PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER
AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND
SIGNED BY SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or
waiver of any right or remedy on any future occasion.

     (g) DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM
OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY
OF THE OTHER DEBT DOCUMENTS, ANY OF THE INDEBTEDNESS

 

 

SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF
THIS TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED
BETWEEN DEBTOR AND SECURED PARTY. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF
ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY
NOT BE MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT
AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR
TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS
AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.

	8.	 	MISCELLANEOUS.

     (a) This Agreement, any Note and/or any of the other Debt Documents may be assigned, in whole
or in part, by Secured Party without notice to Debtor, and Debtor agrees not to assert against any
such assignee, or assignee’s assigns, any defense, set-off, recoupment claim or counterclaim which
Debtor has or may at any time have against Secured Party for any reason whatsoever. Debtor agrees
that if Debtor receives written notice of an assignment from Secured Party, Debtor will pay all
amounts payable under any assigned Debt Documents to such assignee or as instructed by Secured
Party. Debtor also agrees to confirm in writing receipt of the notice of assignment as may be
reasonably requested by Secured Party or assignee.

     (b) All notices to be given in connection with this Agreement shall be in writing, shall be
addressed to the parties at their respective addresses set forth in this Agreement (unless and
until a different address may be specified in a written notice to the other party), and shall be
deemed given (i) on the date of receipt if delivered in hand or by facsimile transmission, (ii) on
the next business day after being sent by express mail, and (iii) on the fourth business day after
being sent by regular, registered or certified mail. As used herein, the term “business day” shall
mean and include any day other than Saturdays, Sundays, or other days on which commercial banks in
New York, New York are required or authorized to be closed.

     (c) Secured
Party may correct patent errors and fill in all blanks in this Agreement or in any
Collateral Schedule consistent with the agreement of the parties.

     (d) Time is of the essence of this Agreement. This Agreement shall be binding, jointly and
severally, upon all parties described as the “Debtor” and their respective heirs, executors,
representatives, successors and assigns, and shall inure to the benefit of Secured Party, its
successors and assigns.

     (e) This Agreement and its Collateral Schedules constitute the entire agreement between the
parties with respect to the subject matter of this Agreement and supersede all prior understandings
(whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND ITS
COLLATERAL SCHEDULES SHALL NOT BE CHANGED OR TERMINATED ORALLY OR BY COURSE OF CONDUCT, BUT ONLY BY
A WRITING SIGNED BY BOTH PARTIES. Section headings contained in this Agreement have been included
for convenience only, and shall not affect the construction or interpretation of this Agreement.

     (f) This Agreement shall continue in full force and effect until all of the Indebtedness has
been indefeasibly paid in full to Secured Party or its assignee. The surrender, upon payment or
otherwise, of any Note or any of the other documents evidencing any of the Indebtedness shall not
affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then
exist or as it may be reasonably contemplated will exist in the future. This Agreement shall
automatically be reinstated if Secured Party is ever required to return or restore the payment of
all or any portion of the Indebtedness (all as though such payment had never been made).

     (g) Upon prior notice and Debtor’s written consent which will not be unreasonably withheld,
Debtor will authorize Secured Party to use its name,
logo and/or trademark in connection with certain promotional materials that Secured Party may
disseminate to the public. The promotional materials may include, but are not limited to,
brochures, video tape, internet website, press releases, advertising in newspaper and/or other
periodicals, lucites, and any other materials relating the fact that Secured Party has a financing
relationship with Debtor. Nothing herein obligates Secured Party to use Debtor’s name, logo and/or
trademark, in any promotional materials of Secured Party.

     (h) THIS AGREEMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER SHALL IN ALL
RESPECTS BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF
CONNECTICUT (WITHOUT REGARD TO THE CONFLICT OF LAWS PRINCIPLES OF SUCH STATE), INCLUDING ALL
MATTERS OF CONSTRUCTION, VALIDITY AND PERFORMANCE, REGARDLESS OF THE LOCATION OF THE COLLATERAL.

 

 

IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have duly
executed this Agreement in one or more counterparts, each of which shall be deemed to be an
original, as of the day and year first aforesaid.

	 	 	 	 	 	 	 
	SECURED PARTY:	 	DEBTOR:
	 
	 	 	 	 	 	 
	General Electric Capital Corporation	 	Alexza Molecular Delivery Corporation
	 
	 	 	 	 	 	 
	By:

	 	/s/ John Eder
	 	By:
	/s/ August J. Moretti
	 

	 	 
	 	 	 
	Name: JOHN EDER

	 	Name: AUGUST J. MORETTI

	Title: SVP

	 	Title: CFO

 

 

AMENDMENT

          THIS AMENDMENT is made as of the 18th day of May, 2005, between General Electric Capital
Corporation (“Secured Party”) and Alexza Molecular Delivery Corporation (“Debtor”) in connection
with that certain Master Security Agreement, dated as of May 17, 2005 (“Agreement”). The terms of
this Amendment are hereby incorporated into the Agreement as though fully set forth therein.
Section references below refer to the section numbers of the Agreement. The Agreement is hereby
amended as follows:

	 	2.	 	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR.

Subsection (m) is hereby added to and made a part of the Agreement and reads as follows:

"(m)
Debtor’s Intellectual Property, as defined in Section 7 below, is and will remain
free and clear of all liens, claims and encumbrances of any kind whatsoever, except for
Permitted Liens as defined in subsection (k) of this Section.”

	 	7.	 	DEFAULT AN REMEDIES.

Subsection (a) (xvii) is hereby added to and made a part of the Agreement and reads as
follows:

(xvii) Debtor or any guarantor or other obligor for any of the Indebtedness sells,
transfers, assigns, mortgages, pledges, leases, grants a security interest in or encumbers
any or all of Debtor’s Intellectual Property now existing or hereafter acquired.
Intellectual Property shall consist of but not be limited to any and all owned or licensed
patents, trademarks and copyrights. For purposes of this paragraph xvii, licenses or
sublicenses by the Debtor of its Intellectual Property as part of a research and
development or similar arrangement shall be excluded. Debtor shall provide Lessor with a
listing of licenses and sublicenses granted to third parties within ten (10) days of
receipt of written request.”

            TERMS USED, BUT NOT OTHERWISE DEFINED HEREIN SHALL HAVE THE MEANINGS GIVEN TO THEM IN THE
AGREEMENT. EXCEPT AS EXPRESSLY AMENDED HEREBY, THE AGREEMENT SHALL REMAIN IN FULL FORCE AND
EFFECT. IF THERE IS ANY CONFLICT BETWEEN THE PROVISIONS OF THE AGREEMENT AND THIS AMENDMENT,
THEN THIS AMENDMENT SHALL CONTROL.

       IN WITNESS WHEREOF, the parties hereto have executed this Amendment simultaneously with the
Agreement by signature of their respective authorized representative set forth below.

	 	 	 	 	 	 	 
	General Electric Capital Corporation	 	Alexza Molecular Delivery Corporation
	 
	 	 	 	 	 	 
	By:

	 	/s/ John Eder
	 	By:
	 	/s/ August J. Moretti
	 

	 	 
	 	 	 	 
	Name:

	 	JOHN EDER
	 	Name:
	 	AUGUST J. MORETTI
	Title:

	 	SVP
	 	Title:
	 	CFO

Amendment to Master Security Agreement

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00095-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00095-of-00352.parquet"}]]