Document:

EXHIBIT 4.1

                             UNIVERSAL EXPRESS, INC.

                            2001 INCENTIVE STOCK PLAN

ARTICLE 1. ESTABLISHMENT AND PURPOSE

           1.1 ESTABLISHMENT OF THE PLAN. Universal Express, Inc., a Nevada
corporation (the "Company" or "Universal Express"), hereby establishes an
incentive compensation plan (the "Plan"), as set forth in this document.

           1.2 PURPOSE OF THE PLAN. The purpose of the Plan is to promote the
success and enhance the value of the Company by linking the personal interests
of Participants to those of the Company's shareholders, and by providing
Participants with an incentive for outstanding performance. The Plan is further
intended to attract and retain the services of Participants upon whose judgment,
interest, and special efforts the successful operation of Universal Express and
its subsidiaries is dependent.

           1.3 EFFECTIVE DATE OF THE PLAN. The Plan shall become effective on
April 20, 2001.

ARTICLE 2. DEFINITIONS

           Whenever used in the Plan, the following terms shall have the
meanings set forth below and, when the meaning is intended, the initial letter
of the word is capitalized:

           (a) "Award" means, individually or collectively, a grant under this
Plan of Stock or Restricted Stock.

           (b) "Award Agreement" means an agreement which may be entered into by
each Participant and the Company, setting forth the terms and provisions
applicable to Awards granted to Participants under this Plan.

           (c) "Board" or "Board of Directors" means the Universal Express Board
of Directors.

           (d) "Consultant" means a natural person under contract with the
Company to provide BONA FIDE services to the Company which are not in connection
with the offer or sale of securities in a capital-raising transaction and do not
directly or indirectly promote or maintain a market for the Company's
securities.

<PAGE>

           (e) "Director" means any individual who is a member of the Universal
Express Board of Directors.

           (f) "Eligible Person" means an Employee, Director or Consultant.

           (g) "Employee" means any officer or employee of the Company or of one
of the Company's Subsidiaries. Directors who are not otherwise employed by the
Company shall not be considered Employees under this Plan.

           (h) "Employment," with reference to an Employee, means the condition
of being an officer or employee of the Company or one of its Subsidiaries.
"Employment," with reference to a Consultant, means the condition of being a
Consultant. "Employment," with reference to a Director, means the condition of
being a Director. The change in status of an Eligible Person among the
categories of Employee, Director and Consultant shall not be deemed a
termination of Employment.

           (i) "Participant" means a person who holds an outstanding Award
granted under the Plan.

           (j)  "Plan" means this 2001 Incentive Stock Plan.

           (k) "Restricted Stock" means an Award of Stock granted to an Eligible
Person pursuant to Article 6 herein.

           (l) "Restriction Period" means the period during which Shares of
Restricted Stock are subject to restrictions or conditions under Article 6.

           (m) "Shares" or "Stock" means the shares of common stock of the
Company.

ARTICLE 3.  SHARES SUBJECT TO THE PLAN

           3.1 NUMBER OF SHARES. Subject to adjustment as provided in Section
3.3 herein, the number of Shares available for grant under the Plan shall not
exceed thirty million (30,000,000) Shares. The Shares granted under this Plan
may be either authorized but unissued or reacquired Shares.

           3.2 LAPSED AWARDS. If any Award granted under this Plan is canceled,
terminates, expires, or lapses for any reason, Shares subject to such Award
shall be again available for the grant of an Award under the Plan.

           3.3 ADJUSTMENTS IN AUTHORIZED PLAN SHARES. In the event of any
merger, reorganization, consolidation, recapitalization, separation,
liquidation, Stock dividend, split-up, Share combina tion, or other change in
the corporate structure of the Company affecting the Shares, an adjust ment
shall be made in the number and class of Shares which may be delivered under the
Plan, as may be determined to be appropriate and equitable by the Board of
Directors, in its sole discretion, to prevent dilution or enlargement of rights.

           No Award may be made under the Plan after December 31, 2005.

ARTICLE 4. ELIGIBILITY AND PARTICIPATION

           4.1 ELIGIBILITY. All Eligible Persons are eligible to participate in
this Plan.

<PAGE>

           4.2 ACTUAL PARTICIPATION. Subject to the provisions of the Plan, the
Board of Directors may, from time to time, select from all Eligible Persons,
those to whom Awards shall be granted and shall determine the nature and amount
of each Award. No Eligible Person is entitled to receive an Award unless
selected by the Board of Directors.

ARTICLE 5.  STOCK GRANT

           5.1 GRANT OF STOCK. Subject to the terms and provisions of the Plan,
the Board of Directors, at any time and from time to time, may grant Shares of
Stock to Eligible Persons in such amounts and upon such terms and conditions as
the Board of Directors shall determine.

ARTICLE 6. RESTRICTED STOCK

           6.1 GRANT OF RESTRICTED STOCK. Subject to the terms and provisions of
the Plan, the Board of Directors, at any time and from time to time, may grant
Shares of Restricted Stock to Eligible Persons in such amounts and upon such
terms and conditions as the Board of Directors shall determine.

           6.2 RESTRICTED STOCK AGREEMENT. The Board of Directors may require,
as a condition to an Award, that a recipient of a Restricted Stock Award enter
into a Restricted Stock Award Agreement, setting forth the terms and conditions
of the Award. In lieu of a Restricted Stock Award Agreement, the Board of
Directors may provide the terms and conditions of an Award in a notice to the
Participant of the Award, on the Stock certificate representing the Restricted
Stock, in the resolution approving the Award, or in such other manner as it
deems appropriate.

           6.3 TRANSFERABILITY. Except as otherwise provided in this Article 6,
the Shares of Restricted Stock granted herein may not be sold, transferred,
pledged, assigned, or otherwise alienated or hypothecated until the end of the
applicable Restriction Period established by the Board of Directors, if any.

           6.4 OTHER RESTRICTIONS. The Board of Directors may impose such other
conditions and/or restrictions on any Shares of Restricted Stock granted
pursuant to the Plan as it may deem advisable including, without limitation, a
requirement that Participants pay a stipulated purchase price for each Share of
Restricted Stock and/or restrictions under applicable Federal or state
securities laws; and may legend the certificates representing Restricted Stock
to give appropriate notice of such restrictions. The Company shall also have the
right to retain the certificates representing Shares of Restricted Stock in the
Company's possession until such time as all conditions and/or restrictions
applicable to such Shares have been satisfied.

           6.5 REMOVAL OF RESTRICTIONS. Except as otherwise provided in this
Article 6, Shares of Restricted Stock covered by each Restricted Stock grant
made under the Plan shall become freely transferable by the Participant after
the last day of the Restriction Period and completion of all conditions to
vesting, if any. However, unless otherwise provided by the Board of Directors,
the Board of Directors, in its sole discretion, shall have the right to
immediately waive all or part of the restrictions and conditions with regard to
all or part of the Shares held by any Participant at any time.

           6.6 VOTING RIGHTS, DIVIDENDS AND OTHER DISTRIBUTIONS. During the
Restriction Period, Participants holding Shares of Restricted Stock granted
hereunder may exercise full voting rights and shall receive all regular cash
dividends paid with respect to such Shares. Except as provided in the following
sentence, in the sole discretion of the Board of Directors, other cash dividends
and other distributions paid to Participants with respect to Shares of
Restricted Stock may be subject to the same restrictions and conditions as the
Shares of Restricted Stock with respect to which they were paid. If any such
dividends or distributions are paid in Shares, the Shares shall

<PAGE>

be subject to the same restrictions and conditions as the Shares of Restricted
Stock with respect to which they were paid.

ARTICLE 7. WITHHOLDING

           7.1 TAX WITHHOLDING. The Company shall deduct or withhold an amount
sufficient to satisfy Federal, state, and local taxes (including the
Participant's employment tax obligations) required by law to be withheld with
respect to any taxable event arising or as a result of this Plan ("Withholding
Taxes").

           7.2 PAYMENT OF WITHHOLDING. With respect to withholding required upon
the lapse of restrictions on Restricted Stock, or upon any other taxable event
hereunder involving the transfer of Stock to a Participant, the Participant
shall be required to remit to the Company an amount in cash sufficient to
satisfy the federal, state and local withholding tax requirements or may direct
the Company to withhold from other amounts payable to the Participant, including
salary.

ARTICLE 8.  LEGAL CONSTRUCTION

           8.1 REQUIREMENTS OF LAW. The granting of Awards and the issuance of
Shares under the Plan shall be subject to all applicable laws, rules, and
regulations, and to such approvals by any governmental agencies or national
securities exchanges as may be required.

           8.2 GOVERNING LAW. To the extent not preempted by Federal law, the
Plan, and all agreements hereunder, shall be construed in accordance with and
governed by the laws of the State of Nevada.

                                    * * * * *

<PAGE>Prepared by MERRILL CORPORATION

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STANDSTILL AGREEMENT    
  

    This Standstill Agreement (the "Agreement") is made as of October 1, 1999 by and between Rosetta
Inpharmatics, Inc., a Delaware corporation (the "Company"), and Hewlett-Packard Company, a Delaware corporation
("Purchaser"). 

 
 

RECITALS    
  

    The Company and Purchaser are parties to (i) that certain Gene Expression Collaboration Agreement dated as of October 1, 1999 (the
"Collaboration Agreement") and (ii) that certain Series D Preferred Stock Purchase Agreement dated as of October 1, 1999 pursuant
to which the Company shall issue and sell shares of its Series D Preferred Stock to Purchaser. In connection with the issuance and sale of such stock, Purchaser desires to make certain
covenants to the Company so as to provide limits on Purchaser's ownership of capital stock of the Company. 

    In
consideration of the foregoing and the mutual promises contained in this Agreement, the parties agree as follows: 

 
 

AGREEMENT    
  

    1.  Definitions  

    For
the purposes of this Agreement, the following words and phrases shall have the following meanings: 

    (a) "Actual Voting Power" means, as of the date of determination, the total number of votes attaching to the outstanding
securities entitled to vote for the election of directors of the Company. 

    (b) "Affiliate" of an entity means, for so long as one of the following relationships is maintained, any corporation or
other business entity controlled by, controlling, or under common or indirect beneficial ownership of more than fifty percent (50%) of the voting stock of such entity (if a corporation), or more than
a fifty percent (50%) interest in the decision-making authority of such entity (if unincorporated). 

    (c) "Investor Group" means Purchaser and its Affiliates. 

    (d) "13D Group" means any group of persons formed for the purpose of acquiring, holding, voting or disposing of Voting
Securities which would be required under the Securities Exchange Act of 1934, as amended (the "Exchange Act") and the rules and regulations promulgated
thereunder, to file a statement on Schedule 13D with the Securities and Exchange Commission as a "person" within the meaning of Section 13(d)(3) of the Exchange Act if such group
beneficially owned sufficient securities to require such a filing under the Exchange Act. 

    (e) "Threshold Percentage" means 19.99 percent. The Threshold Percentage shall be subject to adjustment as
provided below in Section 4(c). 

    (f)  "Total Voting Power" means, as of the date of determination, the total number of votes which may be cast in the
election of directors of the Company at any meeting of stockholders of the Company if all Voting Securities then outstanding are present and voted to the fullest extent possible at such meeting,
assuming the conversion, exchange or exercise of all then outstanding convertible securities, options, warrants or other rights which are convertible into or exchangeable or exercisable for securities
entitled to vote for the election of directors. 

    (g) "Voting Security" means, as of the date of determination, the Common Stock of the Company, any other security
generally entitled to vote for the election of directors and any outstanding convertible securities, options, warrants or other rights which are convertible into or exchangeable or exercisable for
securities entitled to vote for the election of directors. 

 

    2.  Standstill Obligations  

    (a) Limitation.  At any time during the term of this Agreement and prior to the termination of this
Agreement in accordance with Section 4(a) hereof, except with the prior written consent of the Company's Board of Directors (excluding the vote of any director representing, employed by or
otherwise affiliated with any member of the Investor Group), no member of the Investor Group shall, directly or indirectly, (i) acquire any Voting Securities (except by way of (A) stock
splits, stock dividends or other distributions or offerings made available to holders of Voting Securities generally, or (B) stock options, warrants or other rights to purchase Voting
Securities approved by the Board of Directors of the Company (excluding the vote of any director representing, employed by or otherwise affiliated with any member of the Investor Group)) or
(ii) (other than in connection with an actual sale of such securities) exercise any stock options, warrants or other rights to purchase Voting Securities approved by the Board of Directors of
the Company if the effect of such acquisition or exercise would be to increase the percentage interest of the Investor Group in the Actual Voting Power to more than the Threshold Percentage. 

    (b) Recapitalizations, Etc.  Notwithstanding Section 2(a), no member of the Investor Group shall
be obligated to dispose of any Voting Securities if the aggregate percentage ownership of the Investor Group is increased as a result of (i) a recapitalization of the Company, (ii) a
repurchase of Voting Securities by the Company, (iii) any other action taken by the Company or its Affiliates other than the Investor Group. 

    (c) Participation.  Except with the prior written consent of the Company's Board of Directors, the
Investor Group will not (i) solicit proxies in respect of any Voting Securities, (ii) become a "participant" or "participant in a solicitation", as those terms are defined in
Rule 14a-11 under the Exchange Act, in opposition to a solicitation by the Company, (iii) form or join any group for the purpose of voting, purchasing or disposing of Voting
Securities, or (iv) deposit any Voting Securities in a voting trust or subject them to a voting agreement or other arrangement of similar effect, except as contemplated by this Agreement;
provided, however, that the Investor Group shall not be deemed to be a "participant" or to have become engaged in a solicitation hereunder solely by reason of (I) the membership of an
individual representing, employed by or otherwise affiliated with any member of the Investor Group on the Board of Directors, (II) the voting of the Investor Group's Voting Securities in any
election of such representative of the Investor Group to the Board of Directors, or (III) the Company's solicitation of proxies in connection with any annual meeting of the stockholders of the
Company. 

    3.  Exception for Certain Third-Party Acquisitions.  

    (a) Exception to Standstill Obligation.  Notwithstanding Section 2(a), the Investor Group may
acquire Voting Securities without regard to the limitations set forth above but in accordance with Section 3(b) if any of the following events shall occur: 

    (i)  Tender or Exchange Offer.  If a bona fide tender or exchange offer is made by any person or 13D
Group (other than an Affiliate of, or any person acting in concert with, any member of the Investor Group) to acquire Voting Securities which, if added to the Voting Securities (if any) already owned
by such person or 13D Group, would represent ownership of Voting Securities greater than the Threshold Percentage of the Total Voting Power; 

    (ii) Sale or Issuance.  If the Company directly sells or otherwise issues to a person or 13D Group Voting
Securities which, if added to the Voting Securities (if any) already owned by such person or 13D Group, would represent ownership of Voting Securities greater than the Threshold Percentage of the
Total Voting Power; or 

    (iii) Other Transactions.  If it is publicly disclosed or Purchaser otherwise learns that Voting
Securities representing more than the Threshold Percentage of the Total Voting Power 

2

 

have been acquired or are proposed (in a public announcement or filing) to be acquired by any person or 13D Group (other than an Affiliate of, or any person acting in concert with, any member of the
Investor Group). 

    (b) Competing Offers.  If any event identified in Section 3(a) occurs, except an event identified
in Section 3(a)(ii), the Investor Group shall be permitted to take such action and make such offers as may be considered to be of the same nature and type of action or offer and directed to the
same person or persons and for the same resulting number of shares as that which is being taken by such person or 13D Group; provided that the Investor Group may only acquire that number of shares
which when added to the number of shares already owned by the Investor Group shall not exceed the number of shares acquired or to be acquired (assuming any offers to purchase have been consummated) by
such person or 13D Group. In proceeding with any action or offer permitted under this Section 3(b), the Investor Group shall be permitted to offer more favorable terms such as price, cash
versus securities or other such terms as may be consistent with an offer of the same nature and type of consideration as that which is being proposed by such person or 13D Group. 

    For
example (but without limitation): 

    (i)  Tender Offer.  If a person or 13D Group makes a bona fide public tender offer for all of the
Company's outstanding shares, the Investor Group may similarly tender for all of the outstanding shares of the Company. 

    (ii) Other Transaction.  If any person or 13D Group holding less than the Threshold Percentage of the
Total Voting Power acquires in the open market shares equal to a specified percentage of the Total Voting Power in excess of the Threshold Percentage, e.g., forty percent (40%), the Investor Group may
acquire in the open market an additional number of shares that would, if accepted, increase its percentage of the Total Voting Power to be equal to the specified percentage, e.g., an aggregate of
forty percent (40%) of the Total Voting Power. 

    (c) Right to Purchase.  If an event set forth in Section 3(a)(ii) occurs and as a result
any person or 13D Group acquires newly issued Voting Securities directly from the Company which, if added to the Voting
Securities (if any) already owned by such person or 13D Group, represents an amount that exceeds the Threshold Percentage of the Total Voting Power, the Investor Group shall have the right to purchase
from the Company that number of shares of Voting Securities equal to the difference between (i) the number of shares of Voting Securities held by such person or 13D Group and (ii) the
number of shares of Voting Securities equal to the Threshold Percentage of the Total Voting Power, on the same terms and conditions, and subject to the same rights and obligations, as such person or
13D Group acquired such Voting Securities. 

    4.  Miscellaneous  

    (a) Term.  Except as otherwise expressly provided herein, the respective covenants and agreements of the
Parties contained in this Agreement will continue in full force and effect until the earlier of (i) ten years from the date hereof; (ii) six months (the "Six
Month Window") following a termination of the Collaboration Agreement (as defined in the Purchase Agreement) pursuant to clause (i) of Section 10.2 of the
Collaboration Agreement which termination is the result of a material breach of the exclusive or co-exclusive licensing or business relationships set forth in the Collaboration Agreement
by the Company resulting from the Company having entered, directly or indirectly, into any agreement, understanding or arrangement (or commitment with respect thereto) with a Third Party (as defined
in the Collaboration Agreement) regarding the design, development, manufacture, commercialization or use (except with respect to the use by an end-user) of a Collaboration Product (as
defined in the Collaboration Agreement); provided, however, that Purchaser shall not have also breached such exclusivity and/or
co-exclusivity 

3

 

provisions (collectively, a "For Cause Termination"); and (iii) the two year anniversary of the closing of the IPO (as defined below).
Notwithstanding the foregoing, in the event of a For Cause Termination, if during the Six Month Window the Company directly issues and sells Voting Securities to a person or 13D Group in an amount
exceeding the Threshold Percentage of Total Voting Power, this Agreement shall terminate immediately following such issuance and sale. 

    For
the purposes of this Agreement, "IPO" shall mean the sale of the Company's securities pursuant to a registration statement on
Form S-1 filed by the Company under the Securities Act of 1933, as amended, in connection with the initial firm commitment underwritten offering of its securities to the general
public (other than a registration statement relating either to the sale of securities to employees of the Company pursuant to a stock option, stock purchase or similar plan or an SEC Rule 145
transaction). 

    (b) Equitable Relief.  The Parties acknowledge and agree that irreparable damage would occur in the event
any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. Accordingly, it is agreed that the parties shall be entitled to an
injunction or injunctions to prevent or cure breaches of the provisions of this Agreement and to enforce specifically the terms and provisions of this Agreement in any court of the United States or
any state thereof having jurisdiction, in addition to any other remedy to which they may be entitled in law or in equity. 

    (c) Waiver.  The failure of either party to assert a right hereunder or to insist upon compliance with
any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other party. None of the terms,
covenants and conditions of this Agreement can be waived except by the written consent of the party waiving compliance. 

    (d) Amendments and Waivers.  Any term of this Agreement may be amended or waived only with the written
consent of the parties or their respective successors and assigns. Any amendment or waiver effected in accordance with this Section 4(d) shall be binding upon the parties and their respective
successors and assigns. 

    (e) Assignment.  This Agreement may not be assigned by either party without the prior written consent of
the other, except that either party may assign this Agreement to a party which acquires all or substantially all of its assets, whether by merger, sale of assets or otherwise. A merger or
consolidation shall be deemed to constitute an assignment. Subject to the foregoing, the terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any
rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. If the Purchaser shall, on or about November 1, 1999,
transfer certain assets and personnel dealing with the subject matter of the Collaboration Agreement (as defined in the Purchase Agreement) to Agilent Technologies, Inc.
("Agilent"), this Agreement shall on such date be automatically transferred to and be binding upon Agilent. 

    (f)  Governing Law; Jurisdiction.  This Agreement and all acts and transactions pursuant hereto and the
rights and obligations of the parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of Washington, without giving effect to principles of conflicts of
law. Each of the parties to this Agreement consents to the exclusive jurisdiction and venue of the courts of the state and federal courts of King County, Washington. 

    (g) Counterparts.  This Agreement may be executed in two or more counterparts, each of which shall be
deemed an original and all of which together shall constitute one instrument. 

4

 

    (h) Titles and Subtitles.  The titles and subtitles used in this Agreement are used for convenience only
and are not to be considered in construing or interpreting this Agreement. 

    (i)  Notices.  Any notice required or permitted by this Agreement shall be in writing and shall be deemed
sufficient upon receipt, when delivered personally or by courier, overnight delivery service or confirmed facsimile, or forty-eight (48) hours after being deposited in the regular mail as
certified or registered mail (airmail if sent internationally) with postage prepaid, if such notice is addressed to the party to be notified at such party's address or facsimile number as set forth
below, or as subsequently modified by written notice. 

    If
to the Company: 

Rosetta
Inpharmatics, Inc.

12040 115th Avenue NE

Suite 210

Kirkland, WA 98034

Attn: Chief Operating Officer

Facsimile Number: (425) 820-5757 

    with
a copy to: 

William
W. Ericson

Venture Law Group

4750 Carillon Point

Kirkland, WA 98033

Facsimile: (425) 739-8750 

    If
to the Purchaser: 

Hewlett-Packard
Company

3500 Deer Creek Road

Palo Alto, CA 94304

Attn: General Manager, Bioscience Products Group

Facsimile: (650) 852-2975 

    (j)  Severability.  If one or more provisions of this Agreement are held to be unenforceable under
applicable law, the parties agree to renegotiate such provision in good faith, in order to maintain the economic position enjoyed by each party as close as possible to that under the provision
rendered unenforceable. In the event that the parties cannot reach a mutually agreeable and enforceable replacement for such provision, then (i) such provision shall be excluded from this
Agreement, (ii) the balance of the Agreement shall be interpreted as if such provision were so excluded and (iii) the balance of the Agreement shall be enforceable in accordance with its
terms. 

    (k) Attorney's Fees.  If any action at law or in equity is necessary to enforce or interpret the terms of
this Agreement, the prevailing party shall be entitled to reasonable attorney's fees, costs and necessary disbursements in addition to any other relief to which such party may be entitled. 

    (l)  Entire Agreement.  This Agreement is the product of both of the parties hereto, and constitutes the
entire agreement between such parties pertaining to the subject matter hereof, and merges all prior negotiations and drafts of the parties with regard to the transactions contemplated herein. Any and
all other written or oral agreements existing between the parties hereto regarding such transactions are expressly canceled. 

    [Signature
page follows.] 

5

 

    The parties have caused this Agreement to be duly executed and delivered by their proper and duly authorized officers as of the day and year first written above. 

	 	 	COMPANY:
	

 	
 	
ROSETTA INPHARMATICS, INC.
	

 	
 	

By:	
 	

	 	 	Name:	 	

	 	 	Title:	 	

	

 	
 	

Address:

12040 115th Avenue NE

Suite 210

Kirkland, WA 98034
	 	 	Facsimile Number: (425) 820-5757
	

 	
 	
PURCHASER:
	

 	
 	
HEWLETT-PACKARD COMPANY
	

 	
 	

By:	
 	

	 	 	Name:	 	

	 	 	Title:	 	

	

 	
 	

Address:

3500 Deer Creek Road

Palo Alto, CA 94304
	

 	
 	

Facsimile Number: (650) 852-2975

6

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STANDSTILL AGREEMENT

RECITALS

AGREEMENT

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