Document:

Unassociated Document

    Exhibit
      10.1

     

    10,000,000
      Shares

     

    Discovery
      Laboratories, Inc.

     

    Common
      Stock

     

    PLACEMENT
      AGENCY AGREEMENT

     

     

    December
      7, 2007

    

    JEFFERIES
      & COMPANY, INC. 

    c/o
      Jefferies & Company, Inc.

    520
      Madison Avenue

    New
      York,
      New York 10022

     

    Ladies
      and Gentlemen:

     

    Introductory.
      Discovery Laboratories, Inc., a Delaware corporation (the “Company”),
      proposes to issue and sell an aggregate of 10,000,000 shares (the “Offered
      Shares”)
      of its
      common stock, par value $0.001 per share (the “Shares”),
      pursuant to the terms of the Subscription Agreements in the form of Exhibit
      G
      attached
      hereto (the “Subscription
      Agreements”)
      entered into with the purchasers identified therein (each a “Purchaser”
and
      collectively, the “Purchasers”).
      The
      Company hereby confirms its agreement with Jefferies & Company, Inc. to act
      as Placement Agent (the “Placement
      Agent”)
      in
      accordance with the terms and conditions of this Placement Agency Agreement
      (this “Agreement”).
      

     

    The
      Company has prepared and filed with the Securities and Exchange Commission
      (the
“Commission”)
      a
      shelf registration statement on Form S-3 (File No. 333-128929), which
      contains a form of prospectus (the “Base
      Prospectus”)
      to be
      used in connection with the public offering and sale of the Offered Shares.
      Such
      registration statement, as amended, including the financial statements, exhibits
      and schedules thereto, in the form in which it was declared effective by the
      Commission under the Securities Act of 1933, as amended, and the rules and
      regulations promulgated thereunder (collectively, the “Securities
      Act”),
      including all documents incorporated or deemed to be incorporated by reference
      therein and any information deemed to be a part thereof at the time of
      effectiveness pursuant to Rule 430B under the Securities Act or the Securities
      Exchange Act of 1934, as amended, and the rules and regulations promulgated
      thereunder (collectively, the “Exchange
      Act”),
      is
      called the “Registration
      Statement.”
      Any
      registration statement filed by the Company pursuant to Rule 462(b) under the
      Securities Act that relates to the Registration Statement is called the
“Rule
      462(b) Registration Statement,”
and
      from and after the date and time of filing of the Rule 462(b) Registration
      Statement the term “Registration Statement” shall include the Rule 462(b)
      Registration Statement. Such
      prospectus, in the form first used to confirm sales of the Offered Shares,
      is
      called the “Prospectus.”
      As
      used
      herein,“Applicable
      Time”
is
      6:00
      a.m. (New York time) on December
      7, 2007. As
      used
      herein, “free
      writing prospectus”
has
      the
      meaning set forth in Rule 405 under the Securities Act, and “Time
      of Sale Prospectus”
means
      the preliminary prospectus, as amended or supplemented immediately prior to
      the
      Applicable Time, together with the free writing prospectuses, if any, identified
      in Schedule A
      hereto,
      and each “road show” (as defined in Rule 433 under the Securities Act), if any,
      related to the offering of the Offered Shares contemplated hereby that is a
      “written communication” (as defined in Rule 405 under the Securities Act) (each
      such road show, a “Road
      Show”).
      As
      used herein, the terms “Registration Statement,”“Rule
      462(b) Registration Statement”, “preliminary
      prospectus,” “Time of Sale Prospectus” and “Prospectus” shall include the
      documents incorporated and deemed to be incorporated by reference therein.
      All
      references in this Agreement to financial statements and schedules and other
      information which are “contained,”
      “included”
or
      “stated”
in
      the
      Registration Statement, the Rule 462(b) Registration Statement, any preliminary
      prospectus, the Time of Sale Prospectus or the Prospectus (and all other
      references of like import) shall be deemed to mean and include all such
      financial statements and schedules and other information which is or is deemed
      to be incorporated by reference in the Registration Statement or the Prospectus,
      as the case may be; and all references in this Agreement to amendments or
      supplements to the Registration Statement, the Rule 462(b) Registration
      Statement, any preliminary prospectus, the Time of Sale Prospectus or the
      Prospectus, as the case may be, and all references in this Agreement to
      amendments or supplements to the Registration Statement, the Rule 462(b)
      Registration Statement, any preliminary prospectus, the Time of Sale Prospectus
      or the Prospectus shall be deemed to mean and include the filing of any document
      under the Exchange Act which is or is deemed to be incorporated by reference
      in
      the Registration Statement, the Rule 462(b) Registration Statement, any
      preliminary prospectus, the Base Prospectus, the Time of Sale Prospectus or
      the
      Prospectus, as the case may be. All
      references in this Agreement to (i) the
      Registration Statement, the 462(b) Registration Statement, any preliminary
      prospectus, or the Prospectus, or any amendments or supplements to any of the
      foregoing, shall include any copy thereof filed with the Commission pursuant
      to
      its Electronic Data Gathering, Analysis and Retrieval System (“EDGAR”)
      and
      (ii) the Prospectus shall be deemed to include the “electronic
      Prospectus”
      provided for use in connection with the offering of the Offered Shares as
      contemplated by Section 4(n) of this Agreement.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    In
      the
      event that the Company has only one subsidiary, then all references herein
      to
“subsidiaries” of the Company shall be deemed to refer to such single
      subsidiary, mutatis mutandis.

     

    The
      Company hereby confirms its agreement as follows:

     

    Section
      1.  Agreement
      to Act As Placement Agent; Placement of Securities.

     

    On
      the
      basis of the representations, warranties and agreements of the Company herein
      contained, and subject to all the terms and conditions of this
      Agreement:

     

    (a)
      The
      Company hereby authorizes the Placement Agent to act as its exclusive agent
      to
      solicit offers for the purchase of all or part of the Offered Shares from the
      Company in connection with the proposed offering of the Offered Shares (the
      ‘‘Offering’’).
      Until
      the Closing Date (as hereinafter defined) or earlier upon termination of this
      Agreement (as hereinafter provided), the Company shall not, without the prior
      written consent of the Placement Agent, solicit or accept offers to purchase
      Offered Shares otherwise than through the Placement Agent. 

     

    (b)
      The
      Placement Agent agrees, as agent of the Company, to use its best efforts to
      solicit offers to purchase the Offered Shares from the Company. The Placement
      Agent shall use commercially reasonable efforts to assist the Company in
      obtaining performance by each Purchaser whose offer to purchase Offered Shares
      has been solicited by the Placement Agent and accepted by the Company, but
      the
      Placement Agent shall not, except as otherwise provided in this Agreement,
      be
      obligated to disclose the identity of any potential purchaser or have any
      liability to the Company in the event any such purchase is not consummated
      for
      any reason. Under no circumstances will the Placement Agent be obligated to
      underwrite or purchase any Offered Shares for its own account and, in soliciting
      purchases of Offered Shares, the Placement Agent shall act solely as the
      Company’s agent and not as principal. Notwithstanding the foregoing and except
      as otherwise provided in Section 1(b), it is understood and agreed that the
      Placement Agent (or its affiliates) may, solely at its discretion and without
      any obligation to do so, purchase Offered Shares as principal.

     

    
      
        
        

      

      
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    (c)
      Subject to the provisions of this Section 1, offers for the purchase of Offered
      Shares may be solicited by the Placement Agent as agent for the Company at
      such
      times and in such amounts as the Placement Agent deems advisable. The Placement
      Agent shall communicate to the Company, orally or in writing, each reasonable
      offer to purchase Offered Shares received by it as agent of the Company. The
      Company shall have the sole right to accept offers to purchase the Offered
      Shares and may reject any such offer, in whole or in part. The Placement Agent
      shall have the right, in its discretion reasonably exercised, without notice
      to
      the Company, to reject any offer to purchase Offered Shares received by it,
      in
      whole or in part, and any such rejection shall not be deemed a breach of its
      agreement contained herein.

     

    (d)
      The
      Offered Shares are being sold to the Purchasers at a price of $2.50 per Offered
      Share. The purchases of the Offered Shares by the Purchasers shall be evidenced
      by the execution of Subscription Agreements by each of the Purchasers and the
      Company.

     

    (e)
      As
      compensation for services rendered, on the Closing Date, the Company shall
      pay
      to the Placement Agent by wire transfer of immediately available funds to an
      account or accounts designated by the Placement Agent, an aggregate amount
      equal
      to five percent (5%) of
      the
      gross proceeds received by the Company from the sale of the Offered Shares
      on
      such Closing Date.

     

    (f)
      No
      Offered Shares which the Company has agreed to sell pursuant to this Agreement
      shall be deemed to have been purchased and paid for, or sold by the Company,
      until such Offered Shares shall have been delivered to the Purchaser thereof
      against payment by such Purchaser. If the Company shall default in its
      obligations to deliver Offered Shares to a Purchaser whose offer it has
      accepted, the Company shall indemnify and hold the Placement Agent harmless
      against any loss, claim, damage or expense arising from or as a result of such
      default by the Company in accordance with the procedures set forth in Section
      9
      herein.

     

    Section
      2.  Representations
      and Warranties of
      the Company.

     

    The
      Company hereby represents and warrants, as of the date of this Agreement and
      as
      of the Closing Date (as hereinafter defined), and covenants as
      follows:

     

    (a)
      Compliance
      with Registration Requirements.
      The
      Registration Statement and any Rule 462(b) Registration Statement have been
      declared effective by the Commission under the Securities Act. The Company
      has
      complied to the Commission’s satisfaction with all requests of the Commission
      for additional or supplemental information. No stop order suspending the
      effectiveness of the Registration Statement or any Rule 462(b) Registration
      Statement is in effect and no proceedings for such purpose have been instituted
      or are pending or, to the best knowledge of the Company, are contemplated or
      threatened by the Commission.

     

    Each
      preliminary prospectus and the Prospectus when filed complied in all material
      respects with the Securities Act and, if filed by electronic transmission
      pursuant to EDGAR (except as may be permitted by Regulation S-T under the
      Securities Act), was identical to the copy thereof delivered to the Placement
      Agent for use in connection with the offer and sale of the Offered Shares.
      Each
      of the Registration Statement, any Rule 462(b) Registration Statement and
      any post-effective amendment thereto, at the time it became effective and at
      all
      subsequent times, complied and will comply through the completion of the
      distribution of the Offered Shares in all material respects with the Securities
      Act and did not and will not through the completion of the distribution of
      the
      Offered Shares contain any untrue statement of a material fact or omit to state
      a material fact required to be stated therein or necessary to make the
      statements therein not misleading. As of the Applicable Time, the Time of Sale
      Prospectus did not, and at the time of sale of the Offered Shares and at the
      Closing Date (as defined in Section 3), the Time of Sale Prospectus, as then
      amended or supplemented by the Company, if applicable, will not, contain any
      untrue statement of a material fact or omit to state a material fact necessary
      to make the statements therein, in the light of the circumstances under which
      they were made, not misleading. The Prospectus,
      as
      amended or supplemented, as of its date and at all subsequent times through
      the
      completion of the distribution of the Offered Shares, did not and will not
      contain any untrue statement of a material fact or omit to state a material
      fact
      necessary in order to make the statements therein, in the light of the
      circumstances under which they were made, not misleading. The representations
      and warranties set forth in the three immediately preceding sentences do not
      apply to statements in or omissions from the Registration Statement, any
      Rule 462(b) Registration Statement, or any post-effective amendment
      thereto, or the Prospectus or the Time of Sale Prospectus, or any amendments
      or
      supplements thereto, made in reliance upon and in conformity with information
      relating to the Placement Agent furnished to the Company in writing by the
      Placement Agent expressly for use therein, it
      being
      understood and agreed that the only such information furnished by the Placement
      Agent to the Company consists of the information described in Section 9(b)
      below.
      There
      are no contracts or other documents required to be described in the Time of
      Sale
      Prospectus or the Prospectus or to be filed as exhibits to the Registration
      Statement which have not been described or filed as required.

     

    
      
        
        

      

      
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    The
      Company is not an “ineligible issuer” in connection with the offering of the
      Offered Shares pursuant to Rules 164, 405 and 433 under the Securities Act.
      Any
      free writing prospectus that the Company is required to file pursuant to Rule
      433(d) under the Securities Act has been, or will be, filed with the Commission
      in accordance with the requirements of the Securities Act. Each free writing
      prospectus that the Company has filed, or is required to file, pursuant to
      Rule
      433(d) under the Securities Act or that was prepared by or on behalf of or
      used
      or referred to by the Company complies or will comply through the completion
      of
      the distribution of the Offered Shares in all material respects with the
      requirements of Rule 433 under the Securities Act including timely filing with
      the Commission or retention where required and legending, and each such free
      writing prospectus, as of its issue date and at all subsequent times through
      the
      completion of the public offer and sale of the Offered Shares did not, does
      not
      and will not through the completion of the distribution of the Offered Shares
      include any information that conflicted, conflicts with or will through the
      completion of the distribution of the Offered Shares conflict with the
      information contained in the Registration Statement, the Prospectus or any
      preliminary prospectus, including any document incorporated by reference
      therein. Except for the free writing prospectuses, if any, identified in
Schedule
      A
      hereto,
      furnished to the Placement Agent before first use, the Company has not prepared,
      used or referred to, and will not, without your prior consent not to be
      unreasonably withheld, prepare, use or refer to, any free writing
      prospectus.

     

    
      
        
        

      

      
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    (b)
      Offering
      Materials Furnished to Placement
      Agent.
      The
      Company has delivered to the Placement Agent one
      complete
      copy of the Registration Statement, each amendment thereto and any Rule 462(b)
      Registration Statement and of each consent and certificate of experts filed
      as a
      part thereof, and conformed copies of the Registration Statement, each amendment
      thereto and any Rule 462(b) Registration Statement (without exhibits) and
      preliminary prospectuses, the Time of Sale Prospectus, the Prospectus, as
      amended or supplemented, and any free writing prospectus reviewed and consented
      to by the Placement Agent, in such quantities and at such places as the
      Placement Agent has reasonably requested.

     

    (c)
      Distribution
      of Offering Material By the Company.
      The
      Company has not distributed and will not distribute, prior to the completion
      of
      the distribution of the Offered Shares, any offering material in connection
      with
      the offering and sale of the Offered Shares other than a preliminary prospectus,
      the Time of Sale Prospectus, the Prospectus, any free writing prospectus
      reviewed and consented to by the Placement Agent, or the Registration Statement.
      

     

    (d)
      The
      Placement Agency Agreement.
      Each of
      this Agreement, the Subscription Agreements and that certain Escrow Agreement
      (the “Escrow
      Agreement”)
      dated
      as of the date hereof has been duly authorized, executed and delivered by,
      and
      is a valid and binding agreement of, the Company, enforceable in accordance
      with
      its terms, except as rights to indemnification hereunder may be limited by
      applicable law and except as the enforcement hereof may be limited by
      bankruptcy, insolvency, reorganization, moratorium or other similar laws
      relating to or affecting the rights and remedies of creditors or by general
      equitable principles.

     

    (e)
      Authorization
      of the Offered Shares.
      The
      Offered Shares have been duly authorized for issuance and sale pursuant to
      this
      Agreement and, when issued and delivered by the Company pursuant to this
      Agreement, will be validly issued, fully paid and nonassessable, and the
      issuance and sale of the Offered Shares is not subject to any preemptive rights,
      rights of first refusal or other similar rights to subscribe for or purchase
      the
      Offered Shares. 

     

    (f)
      No
      Applicable Registration or Other Similar Rights.
      There
      are no persons with registration or other similar rights to have any equity
      or
      debt securities registered for sale under the Registration Statement or included
      in the offering contemplated by this Agreement.

     

    
      
        
        

      

      
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    (g)
      No
      Material Adverse Change.
      Except
      as otherwise disclosed in the Time of Sale Prospectus, subsequent to the
      respective dates as of which information is given in Time of Sale Prospectus:
      (i)  there has been no material adverse change, or any development that
      could reasonably be expected to result in a material adverse change, in the
      condition, financial or otherwise, or in the earnings, business, operations
      or
      prospects, whether or not arising from transactions in the ordinary course
      of
      business, of the Company and its subsidiaries, considered as one entity (any
      such change is called a “Material
      Adverse Change”);
      (ii) the Company and its subsidiaries, considered as one entity, have not
      incurred any material liability or obligation, indirect, direct or contingent,
      not in the ordinary course of business nor entered into any material transaction
      or agreement not in the ordinary course of business; and (iii) there has
      been no dividend or distribution of any kind declared, paid or made by the
      Company or, except for dividends paid to the Company or other subsidiaries,
      any
      of its subsidiaries on any class of capital stock or repurchase or redemption
      by
      the Company or any of its subsidiaries of any class of capital
      stock.

     

    (h)
      Independent
      Accountants.
      Ernst
      & Young LLP, who have expressed their opinion with respect to the financial
      statements (which term as used in this Agreement includes the related notes
      thereto) and supporting schedules filed with the Commission as a part of the
      Registration Statement and included in the Prospectus and Time of Sale
      Prospectus (each, an “Applicable
      Prospectus”
and
      collectively, the “Applicable
      Prospectuses”),
      are
      (i) independent public or certified public accountants as required by the
      Securities Act and the Exchange Act,
      and (ii)
      a registered public accounting firm as defined by the Public Company Accounting
      Oversight Board (the “PCAOB”).

     

    (i)
      Preparation
      of the Financial Statements.
      The
      financial statements filed with the Commission as a part of the Registration
      Statement and included in the Time of Sale Prospectus and the Prospectus present
      fairly the consolidated financial position of the Company and its subsidiaries
      as of and at the dates indicated and the results of their operations and cash
      flows for the periods specified. The supporting schedules included in the
      Registration Statement present fairly the information required to be stated
      therein. Such financial statements and supporting schedules have been prepared
      in conformity with generally accepted accounting principles as applied in the
      United States
      applied
      on a consistent basis throughout the periods involved, except as may be
      expressly stated in the related notes thereto. No other financial statements
      or
      supporting schedules are required to be included in the Registration Statement
      or any Applicable Prospectus.
      No
      person who has been suspended or barred from being associated with a registered
      public accounting firm, or who has failed to comply with any sanction pursuant
      to Rule 5300 promulgated by the PCAOB, has participated in or otherwise aided
      the preparation of, or audited, the financial statements, supporting schedules
      or other financial data filed with the Commission as a part of the Registration
      Statement and included in any Applicable Prospectus. The
      Company’s ratios of earnings to fixed charges set forth in the Prospectus under
      the caption “Ratio of Earnings to Fixed Charges” and in Exhibit 12 to the
      Registration Statement have been calculated in compliance with Item 503(d)
      of Regulation S-K under the Securities Act.

     

    (j)
      Company’s
      Accounting System.
      The
      Company and each of its subsidiaries make and keep accurate books and records
      and maintain a system of internal
      accounting
      controls sufficient to provide reasonable assurance that: (i) transactions
      are executed in accordance with management’s general or specific authorization;
      (ii)  transactions are recorded as necessary to permit preparation of
      financial statements in conformity with generally accepted accounting principles
      as applied in the United States and to maintain accountability for assets;
      (iii) access to assets is permitted only in accordance with management’s
      general or specific authorization; and (iv) the recorded accountability for
      assets is compared with existing assets at reasonable intervals and appropriate
      action is taken with respect to any differences.
      There
      has not been and is no material weakness in the Company’s internal control
      over financial reporting (whether or not remediated) and since December 31,
      2006, there has been no change in the Company’s internal control over
      financial reporting that has materially affected, or is reasonably likely to
      materially affect, the Company’s internal control over financial
      reporting.

     

    
      
        
        

      

      
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    (k)
      Incorporation
      and Good Standing of the Company and its Subsidiaries.
      Each of
      the Company and its subsidiaries has been duly incorporated or organized, as
      the
      case may be, and is validly existing as a corporation, partnership or limited
      liability company, as applicable, in good standing under the laws of the
      jurisdiction of its incorporation or organization and has the power and
      authority (corporate or other) to own, lease and operate its properties and
      to
      conduct its business as described in each Applicable Prospectus and, in the
      case
      of the Company, to enter into and perform its obligations under this Agreement.
      Each of the Company and each subsidiary is duly qualified as a foreign
      corporation, partnership or limited liability company, as applicable, to
      transact business and is in good standing in the State of Pennsylvania and
      each
      other jurisdiction in which such qualification is required, whether by reason
      of
      the ownership or leasing of property or the conduct of business. All of the
      issued and outstanding capital stock or other equity or ownership interests
      of
      each subsidiary have been duly authorized and validly issued, are fully paid
      and
      nonassessable and are owned by the Company, directly or through subsidiaries,
      free and clear of any security interest, mortgage, pledge, lien, encumbrance
      or
      adverse claim. The Company does not own or control, directly or indirectly,
      any
      corporation, association or other entity other than (i) the subsidiaries listed
      in Exhibit 21
      to the
      Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2006
      and (ii) such other entities omitted from Exhibit 21 which, when such omitted
      entities are considered in the aggregate as a single subsidiary, would not
      constitute a “significant subsidiary” within the meaning of Rule 1-02(w) of
      Regulation S-X. 

     

    (l)
      Capitalization
      and Other Capital Stock Matters.
      The
      authorized, issued and outstanding capital stock of the Company is as set forth
      in each Applicable Prospectus under the caption “Capitalization” (other than for
      subsequent issuances, if any, pursuant to employee benefit plans described
      in
      the Time of Sale Prospectus or upon the exercise of outstanding options or
      warrants described in each Applicable Prospectus). The Shares (including the
      Offered Shares) conform in all material respects to the description thereof
      contained in the Time of Sale Prospectus. All of the issued and outstanding
      Shares have been duly authorized and validly issued, are fully paid and
      nonassessable and have been issued in compliance with federal and state
      securities laws. None of the outstanding Shares was issued in violation of
      any
      preemptive rights, rights of first refusal or other similar rights to subscribe
      for or purchase securities of the Company. There are no authorized or
      outstanding options, warrants, preemptive rights, rights of first refusal or
      other rights to purchase, or equity or debt securities convertible into or
      exchangeable or exercisable for, any capital stock of the Company or any of
      its
      subsidiaries other than those accurately described in each Applicable
      Prospectus. The description of the Company’s stock option, stock bonus and other
      stock plans or arrangements, and the options or other rights granted thereunder,
      set forth in each Applicable Prospectus accurately and fairly presents the
      information required to be shown with respect to such plans, arrangements,
      options and rights. Except
      as
      described in the Prospectus, the Company has not sold or issued any Shares
      during the six-month period preceding the date of the Prospectus, including
      any
      sales pursuant to Rule 144A under, or Regulations D or S of, the Securities
      Act
      other than Shares issued pursuant to employee benefit plans, qualified stock
      options plans or other employee compensation plans or pursuant to outstanding
      options, rights or warrants.

     

    
      
        
        

      

      
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    (m)
      Stock
      Exchange Listing.
      The
      Shares are registered pursuant to Section 12(b) of the Exchange Act and are
      listed on the Nasdaq Global Market, and the Company has taken no action designed
      to, or likely to have the effect of, terminating the registration of the Shares
      under the Exchange Act or delisting the Shares from the Nasdaq Global Market,
      nor has the Company received any notification or have any reason to
      believe that it will or is reasonably likely to receive
      a
      notification that the Commission or the Nasdaq Global Market is contemplating
      terminating such registration or listing, including without limitation for
      any
      violation of Nasdaq Marketplace Rule 4350(i)(1)(D) in connection with this
      Offering or otherwise. 

     

    (n)
      Non-Contravention
      of Existing Instruments; No Further Authorizations or Approvals
      Required.
      Neither
      the Company nor any of its subsidiaries is in violation of its charter or
      by-laws, partnership agreement or operating agreement or similar organizational
      document, as applicable, or is in default (or, with the giving of notice or
      lapse of time, would be in default) (“Default”)
      under
      any indenture, mortgage, loan or credit agreement, note, contract, franchise,
      lease or other instrument to which the Company or any of its subsidiaries is
      a
      party or by which it or any of them may be bound (including, without limitation,
      any credit agreement, indenture, pledge agreement, security agreement or other
      instrument or agreement evidencing, guaranteeing, securing or relating to
      indebtedness of the Company or any of its subsidiaries),
      or to
      which any of the property or assets of the Company or any of its subsidiaries
      is
      subject (each, an “Existing
      Instrument”),
      except for such Defaults as would not, individually or in the aggregate, result
      in a Material Adverse Change. The Company’s execution, delivery and performance
      of each of this Agreement, the Subscription Agreements and the Escrow Agreement,
      the consummation of the transactions contemplated hereby and by each Applicable
      Prospectus and the issuance and sale of the Offered Securities (i) have
      been duly authorized by all necessary corporate action and will not result
      in
      any violation of the provisions of the charter or by-laws, partnership agreement
      or operating agreement or similar organizational document of the Company or
      any
      subsidiary, as applicable, (ii) will not conflict with or constitute a
      breach of, or Default under,
      or
      result in the creation or imposition of any lien, charge or encumbrance upon
      any
      property or assets of the Company or any of its subsidiaries pursuant to, or
      require the consent of any other party to, any Existing Instrument and
      (iii) will not result in any violation of any law, administrative
      regulation or administrative or court decree applicable to the Company or any
      subsidiary. No consent, approval, authorization or other order of, or
      registration or filing with, any court or other governmental or regulatory
      authority or agency, is required for the Company’s execution, delivery and
      performance of this Agreement, the Subscription Agreements and the Escrow
      Agreement and consummation of the transactions contemplated hereby and by each
      Applicable Prospectus, except such
      as
      have been obtained or made by the Company and are in full force and effect
      under
      the Securities Act, applicable state securities or blue sky laws and from the
      NASD.

     

    (o)
      No
      Material Actions or Proceedings.
      Except
      as otherwise disclosed in each Applicable Prospectus, there are no legal or
      governmental actions, suits or proceedings pending or, to the Company’s
      knowledge, threatened (i) against or affecting the Company or any of its
      subsidiaries, (ii) which have as the subject thereof any officer or
      director of, or property owned or leased by, the Company or any of its
      subsidiaries or (iii) relating to environmental or discrimination matters,
      where in any such case (A) there is a reasonable possibility that such
      action, suit or proceeding might be determined adversely to the Company, such
      subsidiary or such officer or director, (B) any such action, suit or
      proceeding, if so determined adversely, would reasonably be expected to result
      in a Material Adverse Change or adversely affect the consummation of the
      transactions contemplated by this Agreement or (C) any such action, suit or
      proceeding is or would be material in the context of the sale of Shares. No
      material labor dispute with the employees of the Company or any of its
      subsidiaries exists or, to the Company’s knowledge, is threatened or
      imminent.

     

    
      
        
        

      

      
        8

        
          

        

      

      
        
        

      

    

     

    (p)
      Intellectual
      Property Rights.
      The
      Company and its subsidiaries own or possess sufficient trademarks, trade names,
      patent rights, copyrights, domain names, licenses, approvals, trade secrets
      and
      other similar rights (collectively, “Intellectual
      Property Rights”)
      reasonably necessary to conduct their businesses as now conducted; and the
      expected expiration of any of such Intellectual Property Rights would not result
      in a Material Adverse Change. Neither the Company nor any of its subsidiaries
      has received, or has any reason to believe that it will receive, any notice
      of
      infringement or conflict with asserted Intellectual Property Rights of others.
      The Company is not a party to or bound by any options, licenses or agreements
      with respect to the Intellectual Property Rights of any other person or entity
      that are required to be set forth in the Prospectus and are not described
      therein. (The Time of Sale Prospectus contains in all material respects the
      same
      description of the matters set forth in the preceding sentence contained in
      the
      Prospectus.) None of the technology employed by the Company or any of its
      subsidiaries has been obtained or is being used by the Company or any of its
      subsidiaries in violation of any contractual obligation binding on the Company
      or any of its subsidiaries or, to the Company’s knowledge, any of its or its
      subsidiaries’ officers, directors or employees or otherwise in violation of the
      rights of any persons. 

     

    (q)
      All
      Necessary Permits, etc.The
      Company and each subsidiary possess such valid and current certificates,
      authorizations or permits issued by the appropriate state, federal or foreign
      regulatory agencies or bodies necessary to conduct their respective businesses,
      and neither the Company nor any subsidiary has received, or has any reason
      to
      believe that it will receive, any notice of proceedings relating to the
      revocation or modification of, or non-compliance with, any such certificate,
      authorization or permit which, singly or in the aggregate, if the subject of
      an
      unfavorable decision, ruling or finding, could result in a Material Adverse
      Change. 

     

    (r)
      Title
      to Properties.
      Except
      as otherwise disclosed in each Applicable Prospectus, the Company and each
      of
      its subsidiaries has good and marketable title to all of the real and personal
      property and other assets reflected as owned in the financial statements
      referred to in Section 2 (i) above (or elsewhere in any Applicable
      Prospectus), in each case free and clear of any security interests, mortgages,
      liens, encumbrances, equities, adverse claims and other defects, except such
      as
      do not materially and adversely affect the value of such property and do not
      materially interfere with the use made or proposed to be made of such property
      by the Company or such subsidiary. The real property, improvements, equipment
      and personal property held under lease by the Company or any subsidiary are
      held
      under valid and enforceable leases, with such exceptions as are not material
      and
      do not materially interfere with the use made or proposed to be made of such
      real property, improvements, equipment or personal property by the Company
      or
      such subsidiary.

     

    (s)
      Tax
      Law Compliance.
      The
      Company and its consolidated subsidiaries have filed all necessary federal,
      state and foreign income and franchise tax returns and have paid all taxes
      required to be paid by any of them and, if due and payable, any related or
      similar assessment, fine or penalty levied against any of them. The Company
      has
      made adequate charges, accruals and reserves in the applicable financial
      statements referred to in Section 2
      (i)
      above in respect of all federal, state and foreign income and franchise taxes
      for all periods as to which the tax liability of the Company or any of its
      consolidated subsidiaries has not been finally determined.

     

    
      
        
        

      

      
        9

        
          

        

      

      
        
        

      

    

     

    (t)
      Company
      Not an “Investment Company”.
      The
      Company has been advised of the rules and requirements under the Investment
      Company Act of 1940, as amended (the “Investment
      Company Act”).
      The
      Company is not, and will not be, either after receipt of payment for the Offered
      Shares or after the application of the proceeds therefrom as described under
      “Use of Proceeds” in each Applicable Prospectus, an “investment
      company”
within
      the meaning of Investment Company Act.

     

    (u)
      Insurance.
      Each of
      the Company and its subsidiaries are insured pursuant to policies in such
      amounts and with such deductibles and covering such risks as are generally
      deemed adequate and customary for their businesses including, but not limited
      to, policies covering real and personal property owned or leased by the Company
      and its subsidiaries against theft, damage, destruction, acts of vandalism
      and
      policies covering the Company and its subsidiaries for product liability claims
      and clinical trial liability claims. The Company has no reason to believe that
      it or any subsidiary will not be able (i) to renew its existing insurance
      coverage as and when such policies expire or (ii) to obtain comparable
      coverage from similar institutions as may be necessary or appropriate to conduct
      its business as now conducted and at a cost that would not result in a Material
      Adverse Change. Neither of the Company nor any subsidiary has been denied any
      insurance coverage which it has sought or for which it has applied.

     

    (v)
      No
      Price
      Stabilization or Manipulation;
      Compliance with Regulation M.
      The
      Company has not taken, directly or indirectly, any action designed to or that
      might be reasonably expected to cause or result in stabilization or manipulation
      of the price of the Shares or any other “reference
      security”
      (as
      defined in Rule 100 of Regulation M under the Exchange Act (“Regulation
      M”))
      whether to facilitate the sale or resale of the Offered Shares or otherwise,
      and
      has taken no action which would directly or indirectly violate Regulation
      M. 

     

    (w)
      Related
      Party Transactions.
      There
      are no business relationships or related-party transactions involving the
      Company or any of its subsidiaries or any other person required to be described
      in each Applicable Prospectus which have not been described as required.
(The
      Time
      of Sale Prospectus contains in all material respects the same description of
      the
      matters set forth in the preceding sentence contained in the
      Prospectus.)

     

    (x)
      NASD
      Matters.
      All
      of
      the information provided to the Placement Agent or to counsel for the Placement
      Agent by the Company, its officers and directors and the holders of any
      securities (debt or equity) or options to acquire any securities of the Company
      in connection with letters, filings or other supplemental information provided
      to NASD Regulation Inc. pursuant to NASD Conduct Rule 2710 or 2720, if
      any, is true, complete and correct.

     

    (y)
      Parties
      to Lock-Up Agreements.
      Each of
      the Company’s directors and executive officers listed in Exhibit C
      has
      executed and delivered to the Placement Agent a lock-up agreement substantially
      in the form of Exhibit D
      hereto.
Exhibit C
      hereto
      contains a true, complete and correct list of all directors and executive
      officers of the Company. If any additional persons shall become directors or
      executive
      officers
      of the Company prior to the end of the Company Lock-up Period (as defined
      below), the Company shall cause each such person,
      prior
      to or contemporaneously with their appointment or election as a director or
      executive officer of the Company,
      to
      execute and deliver to the Placement Agent an agreement in the form attached
      hereto as Exhibit
      D.

     

    
      
        
        

      

      
        10

        
          

        

      

      
        
        

      

    

     

    (z)
      Statistical
      and Market-Related Data.
      The
      statistical, demographic and market-related data included in the Registration
      Statement and each Applicable Prospectus are based on or derived from sources
      that the Company believes to be reliable and accurate or represent the Company’s
      good faith estimates that are made on the basis of data derived from such
      sources.

     

    (aa)
      S-3 Eligibility. At
      the
      time the Registration Statement was originally declared effective and at the
      time the Company’s Annual Report on Form 10-K for the year ended
      December 31, 2006 (the “Annual
      Report”)
      was
      filed with the Commission, the Company met the then applicable requirements
      for
      use of Form S-3 under the Securities Act. The Company meets the
      requirements for use of Form S-3 under the Securities Act specified in
      Conduct Rule 2710(b)(7)(C)(i) of the National Association of Securities
      Dealers Inc. (the “NASD”).

     

    (bb)
      Exchange Act Compliance.The
      documents incorporated or deemed to be incorporated by reference in the
      Prospectus, at the time they were or hereafter are filed with the Commission,
      complied and will comply in all material respects with the requirements of
      the
      Exchange Act, and, when read together with the other information in the
      Prospectus, at the time the Registration Statement and any amendments thereto
      become effective and at the Closing Date will not contain an untrue statement
      of
      a material fact or omit to state a material fact required to be stated therein
      or necessary to make the fact required to be stated therein or necessary to
      make
      the statements therein, in the light of the circumstances under which they
      were
      made, not misleading.

     

    (cc)
      No
      Unlawful Contributions or Other Payments.
      Neither
      the Company nor any of its subsidiaries nor, to the Company’s knowledge, any
      employee or agent of the Company or any subsidiary, has made any contribution
      or
      other payment to any official of, or candidate for, any federal, state or
      foreign office in violation of any law or regulation of the character required
      to be disclosed in the Registration
      Statement and each Applicable Prospectus.

     

    (dd) Disclosure
      Controls and Procedures; Deficiencies in or Changes to Internal Control Over
      Financial Reporting.
      The
      Company has established and maintains disclosure controls and procedures
      (as
      defined in Exchange Act Rules 13a-15(e) and 15d-15(e)),
      which
      (i) are designed to ensure that material information relating to the Company,
      including its consolidated subsidiaries, is made known to the Company’s
      principal executive officer and its principal financial officer by others within
      those entities, particularly during the periods in which the periodic reports
      required under the Exchange Act are being prepared; (ii) have been evaluated
      by
      management of the Company for effectiveness as of the
      end
      of the Company’s most recent fiscal quarter;
      and
      (iii) are effective in all material respects to perform the functions for which
      they were established. The Company is not aware of (i) any significant
      deficiencies or material weaknesses in the design or operation of internal
      control over financial reporting which are reasonably likely to adversely affect
      the Company’s ability to record, process, summarize and report financial
      information or (ii) any fraud, whether or not material, that involves management
      or other employees who have a significant role in the Company’s internal control
      over financial reporting.
      The
      Company is not aware of any change in its internal control over financial
      reporting that has occurred during its most recent fiscal quarter that has
      materially affected, or is reasonably likely to materially affect, the Company’s
      internal control over financial reporting.  

     

    
      
        
        

      

      
        11

        
          

        

      

      
        
        

      

    

     

    (ee) Compliance
      with Environmental Laws.
      Except
      as
      described in each
      Applicable Prospectus
      and
      except as would not, singly or in the aggregate, result in a Material Adverse
      Change, (i) neither the Company nor any of its subsidiaries is in violation
      of
      any federal, state, local or foreign statute, law, rule, regulation, ordinance,
      code, policy or rule of common law or any judicial or administrative
      interpretation thereof, including any judicial or administrative order, consent,
      decree or judgment, relating to pollution or protection of human health, the
      environment (including, without limitation, ambient air, surface water,
      groundwater, land surface or subsurface strata) or wildlife, including, without
      limitation, laws and regulations relating to the release or threatened release
      of chemicals, pollutants, contaminants, wastes, toxic substances, hazardous
      substances, petroleum or petroleum products (collectively, “Hazardous
      Materials”)
      or to
      the manufacture, processing, distribution, use, treatment, storage, disposal,
      transport or handling of Hazardous Materials (collectively, “Environmental
      Laws”),
      (ii)
      the Company and its subsidiaries have all permits, authorizations and approvals
      required under any applicable Environmental Laws and are each in compliance
      with
      their requirements, (iii) there are no pending or, to the Company’s knowledge,
      threatened administrative, regulatory or judicial actions, suits, demands,
      demand letters, claims, liens, notices of noncompliance or violation,
      investigation or proceedings relating to any Environmental Law against the
      Company or any of its subsidiaries and (iv) there are no events or circumstances
      that might reasonably be expected to form the basis of an order for clean-up
      or
      remediation, or an action, suit or proceeding by any private party or
      governmental body or agency, against or affecting the Company or any of its
      subsidiaries relating to Hazardous Materials or any Environmental
      Laws.

     

    (ff) ERISA
      Compliance.
      The
      Company and its subsidiaries and any “employee
      benefit plan”
(as
      defined under the Employee Retirement Income Security Act of 1974, as amended,
      and the regulations and published interpretations thereunder (collectively,
      “ERISA”))
      established or maintained by the Company, its subsidiaries or their
“ERISA
      Affiliates”
(as
      defined below) are in compliance in all material respects with ERISA.
“ERISA
      Affiliate”
means,
      with respect to the Company or a subsidiary, any member of any group of
      organizations described in Sections 414(b), (c), (m) or (o) of the Internal
      Revenue Code of 1986, as amended, and the regulations and published
      interpretations thereunder (the “Code”)
      of
      which the Company or such subsidiary is a member. No “reportable
      event”
(as
      defined under ERISA) has occurred or is reasonably expected to occur with
      respect to any “employee
      benefit plan”
      established or maintained by the Company, its subsidiaries or any of their
      ERISA
      Affiliates. No “employee
      benefit plan”
      established or maintained by the Company, its subsidiaries or any of their
      ERISA
      Affiliates, if such “employee
      benefit plan”
were
      terminated, would have any “amount
      of unfunded benefit liabilities”
(as
      defined under ERISA). Neither the Company, its subsidiaries nor any of their
      ERISA Affiliates has incurred or reasonably expects to incur any liability
      under
      (i) Title IV of ERISA with respect to termination of, or withdrawal
      from, any “employee
      benefit plan”
or
      (ii) Sections 412, 4971, 4975 or 4980B of the Code. Each “employee
      benefit plan”
      established or maintained by the Company, its subsidiaries or any of their
      ERISA
      Affiliates that is intended to be qualified under Section 401(a) of the
      Code is so qualified and nothing has occurred, whether by action or failure
      to
      act, which would cause the loss of such qualification. 

     

    (gg) Brokers.
      Except
      for the fee payable to the Placement Agent as described in
      the
Time
      of
      Sale Prospectus and the Prospectus, there is no broker, finder or other party
      that is entitled to receive from the Company any brokerage or finder’s fee or
      other fee or commission as a result of any transactions contemplated by this
      Agreement.

     

    
      
        
        

      

      
        12

        
          

        

      

      
        
        

      

    

     

    (hh) No
      Outstanding Loans or Other Extensions of Credit.Since
      the
      adoption of Section 13(k) of the Exchange Act, neither the Company nor any
      of
      its subsidiaries has extended or maintained credit, arranged for the extension
      of credit, or renewed any extension of credit, in the form of a personal loan,
      to or for any director or executive officer (or equivalent thereof) of the
      Company and/or such subsidiary except for such extensions of credit as are
      expressly permitted by Section 13(k) of the Exchange Act.

     

    (ii) Compliance
      with Laws.
      The
      Company has not been advised, and has no reason to believe, that it and each
      of
      its subsidiaries are not conducting business in compliance with all applicable
      laws, rules and regulations of the jurisdictions in which it is conducting
      business, except where failure to be so in compliance would not result in a
      Material Adverse Change. 

     

    (jj) Foreign
      Corrupt Practices Act.
      Neither
      the Company nor any of its subsidiaries nor, to the knowledge of the Company,
      any director, officer, agent, employee, affiliate or other person acting on
      behalf of the Company or any of its subsidiaries is aware of or has taken any
      action, directly or indirectly, that has resulted or would result in a violation
      of the Foreign Corrupt Practices Act of 1977, as amended, and the rules and
      regulations thereunder (the “FCPA”),
      including, without limitation, making use of the mails or any means or
      instrumentality of interstate commerce corruptly in furtherance of an offer,
      payment, promise to pay or authorization of the payment of any money, or other
      property, gift, promise to give, or authorization of the giving of anything
      of
      value to any “foreign official” (as such term is defined in the FCPA) or any
      foreign political party or official thereof or any candidate for foreign
      political office, in contravention of the FCPA; and the Company and its
      subsidiaries and, to the knowledge of the Company, the Company’s affiliates have
      conducted their respective businesses in compliance with the FCPA.

     

    (kk) OFAC.
      Neither
      the Company nor any of its subsidiaries nor, to the knowledge of the Company,
      any director, officer, agent, employee, affiliate or person acting on behalf
      of
      the Company or any of its subsidiaries is currently subject to any U.S.
      sanctions administered by the Office of Foreign Assets Control of the U.S.
      Treasury Department (“OFAC”);
      and
      the Company will not directly or indirectly use the proceeds of this offering,
      or lend, contribute or otherwise make available such proceeds to any subsidiary,
      joint venture partner or other person or entity, for the purpose of financing
      the activities of any person currently subject to any U.S. sanctions
      administered by OFAC.

     

    Any
      certificate signed by any officer of the Company or any of its subsidiaries
      and
      delivered to the Placement Agent or to counsel for the Placement Agent shall
      be
      deemed a representation and warranty by the Company to the Placement Agent
      as to
      the matters covered thereby.

     

    The
      Company acknowledges that the Placement Agent and, for purposes of the opinions
      to be delivered pursuant to Section 7 hereof, counsel to the Company and counsel
      to the Placement Agent, will rely upon the accuracy and truthfulness of the
      foregoing representations and hereby consents to such reliance.

     

    Section
      3. Purchase,
      Sale and Delivery of the Offered Shares.

     

     (a)
      The
      Offered Shares.
      The
      Company agrees to issue and sell to the Purchasers the Offered Shares upon
      the
      terms set forth in the Subscription Agreements. The purchase price per Offered
      Share to be paid by the Purchasers to the Company shall be $2.50 per
      share.

     

    
      
        
        

      

      
        13

        
          

        

      

      
        
        

      

    

     

    (b)
      The
      Closing Date.
      Delivery of certificates for the Offered Shares to be purchased by the
      Purchasers and payment therefor shall be made at the offices of the Placement
      Agent, 520 Madison Avenue, New York, New York (or such other place as may
      be agreed to by the Company and the Placement Agent) at 9:00 a.m. New York
      time,
      on December
      12, 2007
      (the
      time and date of such closing are called the “Closing
      Date”).
      The
      Company hereby acknowledges that circumstances under which the Placement Agent
      may provide notice to postpone the Closing Date as originally scheduled include,
      but are in no way limited to, any determination by the Company or the Placement
      Agent to recirculate to the public copies of an amended or supplemented
      Prospectus.

     

    (c)
      Payment
      for the Offered Shares.
      Payment
      for the Offered Shares shall be made at the Closing Date by wire transfer of
      immediately available funds to the order of the Company. 

     

     (d)
      Delivery
      of the Offered Shares.
      The
      Company shall deliver, or cause to be delivered, to the Purchasers certificates
      for the Offered Shares at the Closing Date, against the irrevocable release
      of a
      wire transfer of immediately available funds for the amount of the purchase
      price therefor. The certificates for the Offered Shares shall be in definitive
      form and registered in such names and denominations as the Purchasers shall
      have
      requested at least two full business days prior to the Closing Date and shall
      be
      made available for inspection on the business day preceding the Closing Date
      at
      a location in New York City as the Placement Agent may designate. Time shall
      be
      of the essence, and delivery at the time and place specified in this Agreement
      is a further condition to the obligations of the Purchasers.

     

    Section
      4. Additional
      Covenants. 

     

    The
      Company further covenants and agrees with the Placement Agent as
      follows:

     

    (a) Delivery
      of Registration Statement, Time of Sale Prospectus and
      Prospectus.Upon
      request, the Company shall furnish to the Placement Agent, without charge,
      two
      copies of the Registration Statement, any amendments thereto and any Rule 462(b)
      Registration Statement (including exhibits thereto) and shall furnish to the
      Placement
      Agent
      in New
      York City, without charge, prior to 10:00 a.m. New York City time on the
      business day next succeeding the date of this Agreement and during the period
      mentioned in Section 4(e) or 4(f) below, as many copies of the Time of Sale
      Prospectus, the Prospectus and any supplements and amendments thereto or to
      the
      Registration Statement as the Placement
      Agent
      may
      reasonably request.

     

    (b) Placement
      Agent’s Review of Proposed Amendments and Supplements.Prior
      to
      amending or supplementing the Registration Statement (including any registration
      statement filed under Rule 462(b) under the Securities Act), any
      preliminary prospectus, the Time of Sale Prospectus or the Prospectus (including
      any amendment or supplement through incorporation of any report filed under
      the
      Exchange Act), the Company shall furnish to the Placement
      Agent
      for
      review, a reasonable amount of time prior to the proposed time of filing or
      use
      thereof, a copy of each such proposed amendment or supplement, and the Company
      shall not file or use any such proposed amendment or supplement without the
      Placement Agent’s consent (which shall not be unreasonably withheld), and to
      file with the Commission within the applicable period specified in Rule 424(b)
      under the Securities Act any prospectus required to be filed pursuant to such
      Rule.

     

    
      
        
        

      

      
        14

        
          

        

      

      
        
        

      

    

     

    (c)
      Free
      Writing Prospectuses.The
      Company shall furnish to the Placement
      Agent
      for
      review, a reasonable amount of time prior to the proposed time of filing or
      use
      thereof, a copy of each proposed free writing prospectus or any amendment or
      supplement thereto to be prepared by or on behalf of, used by, or referred
      to by
      the Company and the Company shall not file, use or refer to any proposed free
      writing prospectus or any amendment or supplement thereto without the Placement
      Agent’s consent. Upon request, the
      Company shall furnish to the Placement Agent, without charge, as many copies
      of
      any free writing prospectus prepared by or on behalf of, or used by the Company,
      as the Placement Agent may reasonably request. If at any time when a prospectus
      is required by the Securities Act (including, without limitation, pursuant
      to
      Rule 173(d)) to be delivered in connection with sales of the Offered Shares
      (but in any event if at any time through and including the Closing Date) there
      occurred or occurs an event or development as a result of which any free writing
      prospectus prepared by or on behalf of, used by, or referred to by the Company
      conflicted or would conflict with the information contained in the Registration
      Statement or included or would include an untrue statement of a material fact
      or
      omitted or would omit to state a material fact necessary in order to make the
      statements therein, in the light of the circumstances prevailing at that
      subsequent time, not misleading, the Company shall promptly amend or supplement
      such free writing prospectus to eliminate or correct such conflict or so that
      the statements in such free writing prospectus as so amended or supplemented
      will not include an untrue statement of a material fact or omit to state a
      material fact necessary in order to make the statements therein, in the light
      of
      the circumstances prevailing at such subsequent time, not misleading, as the
      case may be; provided, however, that prior to amending or supplementing any
      such
      free writing prospectus, the Company shall furnish to the Placement Agent for
      review, a reasonable amount of time prior to the proposed time of filing or
      use
      thereof, a copy of such proposed amended or supplemented free writing prospectus
      and the Company shall not file, use or refer to any such amended or supplemented
      free writing prospectus without the Placement Agent’s consent.

     

    (d)
      Filing
      of Free Writing Prospectuses.
      The
      Company shall not to take any action that would result in the Placement
      Agent
      or the
      Company being required to file with the Commission pursuant to Rule 433(d)
      under
      the Securities Act a free writing prospectus prepared by or on behalf of the
      Placement
      Agent
      that the
Placement
      Agent
      otherwise would not have been required to file thereunder.

     

    (e)
      Amendments
      and Supplements to Time of Sale Prospectus.
      If
      the
      Time of Sale Prospectus is being used to solicit offers to buy the Shares at
      a
      time when the Prospectus is not yet available to prospective purchasers and
      any
      event shall occur or condition exist as a result of which it is necessary to
      amend or supplement the Time of Sale Prospectus so
      that
      the Time of Sale Prospectus does not include an untrue statement of a material
      fact or omit to state a material fact necessary in
      order
      to make the statements therein, in the light of the circumstances when
      delivered to a prospective purchaser,
      not
      misleading, or if any event shall occur or condition exist as a result of which
      the Time of Sale Prospectus conflicts with the information contained in the
      Registration Statement, or if, in the opinion of counsel for the Placement
      Agent,
      it is
      necessary to amend or supplement the Time of Sale Prospectus to comply with
      applicable law, including the Securities Act, the Company shall (subject to
      Sections 4(b) and 4(c)) forthwith prepare, file with the Commission and furnish,
      at its own expense, to the Placement
      Agent
      and to
      any dealer upon request, either amendments or supplements to the Time of Sale
      Prospectus so that the statements in the Time of Sale Prospectus as so amended
      or supplemented will not
      include
      an untrue statement of a material fact or omit to state a material fact
      necessary in order to make the statements therein,
      in the
      light of the circumstances when delivered to a prospective purchaser, not
      misleading or so that the Time of Sale Prospectus, as amended or supplemented,
      will no longer conflict with the Registration Statement, or so that the Time
      of
      Sale Prospectus, as amended or supplemented, will comply with applicable law
      including the Securities Act.

     

    
      
        
        

      

      
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    (f)
      Securities
      Act Compliance.
      After
      the date of this Agreement, the Company shall promptly advise the Placement
      Agent
      in
      writing (i) of the receipt of any comments of, or requests for additional or
      supplemental information from, the Commission, (ii) of the time and date of
      any
      filing of any post-effective amendment to the Registration Statement, any Rule
      462(b) Registration Statement or any amendment or supplement to any Prospectus,
      the Time of Sale Prospectus, any free writing prospectus or the Prospectus,
      (iii) of the time and date that any post-effective amendment to the Registration
      Statement or any Rule 462(b) Registration Statement becomes effective and (iv)
      of the issuance by the Commission of any stop order suspending the effectiveness
      of the Registration Statement or any post-effective amendment thereto, any
      Rule
      462(b) Registration Statement or any amendment or supplement to any preliminary
      prospectus, the Time of Sale Prospectus or the Prospectus or of any order
      preventing or suspending the use of any preliminary prospectus, the Time of
      Sale
      Prospectus, any free writing prospectus or the Prospectus, or of any proceedings
      to remove, suspend or terminate from listing or quotation the Shares from any
      securities exchange upon which they are listed for trading or included or
      designated for quotation, or of the threatening or initiation of any proceedings
      for any of such purposes. If the Commission shall enter any such stop order
      at
      any time, the Company will use its best efforts to obtain the lifting of such
      order at the earliest possible moment. Additionally, the Company agrees that
      it
      shall comply with the provisions of Rule 424(b), Rule 433 and Rule 430B, as
      applicable, under the Securities Act and will use its reasonable efforts to
      confirm that any filings made by the Company under such Rule 424(b) or Rule
      433
      were received in a timely manner by the Commission. 

     

    (g)
      Amendments
      and Supplements to the Prospectus and Other Securities Act Matters.
      If any
      event shall occur or condition exist as a result of which it is necessary to
      amend or supplement the Prospectus so that the Prospectus does not
      include
      an untrue statement of a material fact or omit to state a material fact
      necessary in
      order
      to make the statements therein, in the light of the circumstances when the
      Prospectus is delivered to a purchaser, not misleading, or if in the reasonable
      opinion of the Placement Agent or counsel for the Placement
      Agent
      it is
      otherwise necessary to amend or supplement the Prospectus to comply with
      applicable law, including the Securities Act, the Company agrees (subject to
      Section 4(b) and 4(c)) to promptly prepare, file with the Commission and
      furnish at its own expense to the Placement
      Agent
      and to
      dealers, amendments or supplements to the Prospectus so that the statements
      in
      the Prospectus as so amended or supplemented will not
      include
      an untrue statement of a material fact or omit to state a material fact
      necessary
      in order
      to make the statements therein, in the light of the circumstances when the
      Prospectus is delivered to a purchaser, not misleading or so that the
      Prospectus, as amended or supplemented, will comply with applicable law
      including the Securities Act. Neither the Placement Agent’s consent to, or
      delivery of, any such amendment or supplement shall constitute a waiver of
      any
      of the Company’s obligations under Sections 4(b) or 4(c).

     

    (h)
      Blue
      Sky Compliance.
      The
      Company shall cooperate with the Placement
      Agent
      and
      counsel for the Placement
      Agent
      to
      qualify or register the Offered Shares for sale under (or obtain exemptions
      from
      the application of) the state securities or blue sky laws of
      those
      jurisdictions designated by the Placement
      Agent,
      shall
      comply with such laws and shall continue such qualifications, registrations
      and
      exemptions in effect so long as required for the distribution of the Offered
      Shares. The Company shall not be required to qualify as a foreign corporation
      or
      to take any action that would subject it to general service of process in any
      such jurisdiction where it is not presently qualified or where it would be
      subject to taxation as a foreign corporation. The Company will advise the
Placement
      Agent
      promptly
      of the suspension of the qualification or registration of (or any such exemption
      relating to) the Offered Shares for offering, sale or trading in any
      jurisdiction or any initiation or threat of any proceeding for any such purpose,
      and in the event of the issuance of any order suspending such qualification,
      registration or exemption, the Company shall use its best efforts to obtain
      the
      withdrawal thereof at the earliest possible moment.

     

    
      
        
        

      

      
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    (i)
      Use
      of Proceeds.
      The
      Company shall apply the net proceeds from the sale of the Offered Shares sold
      by
      it in the manner described under the caption “Use of Proceeds” in each
      Applicable Prospectus.

     

    (j)
      Transfer
      Agent.
      The
      Company shall engage and maintain, at its expense, a registrar and transfer
      agent for the Shares.

     

    (k)
      Earnings
      Statement.
      As soon
      as practicable, but in any event no later than 12 months after the date of
      this
      Agreement, the Company will make generally available to its security holders
      and
      upon request to the Placement
      Agent
      an
      earnings statement (which need not be audited) covering a period of at least
      12
      months beginning after the date of this Agreement which shall satisfy the
      provisions of Section 11(a) of the Securities Act and the rules and regulations
      of the Commission thereunder.

     

    (l)
      Exchange
      Act Compliance.
      During
      the period when a prospectus is required by the Securities Act to be delivered
      in connection with sales of the Offered Shares (but in any event if at any
      time
      through and including the Closing Date), the Company shall file all documents
      required to be filed with the Commission pursuant to Section 13, 14 or 15 of
      the
      Exchange Act in the manner and within the time periods required by the Exchange
      Act.

     

    (m)
      Listing.
      The
      Company will use its best efforts to maintain the listing of the Shares on
      the
      Nasdaq Global Market.

     

    (n)
      Company
      to Provide Copy of the Prospectus in Form That May be Downloaded from the
      Internet.
      The
      Company shall cause to be prepared and delivered, at its expense, within one
      business day from the effective date of this Agreement, to the Placement Agent
      an “electronic
      Prospectus”
to
      be
      used by the Placement Agent in connection with the offering and sale of the
      Offered Shares. As used herein, the term “electronic
      Prospectus”
means
      a
      form of Time of Sale Prospectus, and any amendment or supplement thereto, that
      meets each of the following conditions: (i) it shall be encoded in an electronic
      format, satisfactory to the Placement Agent, that may be transmitted
      electronically by the Placement Agent to offerees and purchasers of the Offered
      Shares; (ii) it shall disclose the same information as the paper Time of
      Sale Prospectus, except to the extent that graphic and image material cannot
      be
      disseminated electronically, in which case such graphic and image material
      shall
      be replaced in the electronic Prospectus with a fair and accurate narrative
      description or tabular representation of such material, as appropriate; and
      (iii) it shall be in or convertible into a paper format or an electronic
      format, satisfactory to the Placement Agent, that will allow investors to store
      and have continuously ready access to the Time of Sale Prospectus at any future
      time, without charge to investors (other than any fee charged for subscription
      to the Internet as a whole and for on-line time). The Company hereby confirms
      that it has included or will include in the Prospectus filed pursuant to EDGAR
      or otherwise with the Commission and in the Registration Statement at the time
      it was declared effective an undertaking that, upon receipt of a request by
      an
      investor or his or her representative, the Company shall transmit or cause
      to be
      transmitted promptly, without charge, a paper copy of the Time of Sale
      Prospectus.

     

    
      
        
        

      

      
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    (o)
      Agreement
      Not to Offer or Sell Additional Shares.
      During
      the period commencing on and including the date hereof and ending on and
      including the 60 day following the date of this Agreement (as the same may
      be
      extended as described below, the “Lock-up
      Period”),
      the
      Company will not, without the prior written consent of the Placement Agent,
      directly or indirectly, sell (including, without limitation, any short sale),
      offer, contract or grant any option to sell, pledge, transfer or establish
      an
      open “put equivalent position” within the meaning of Rule 16a-1(h) under the
      Exchange Act, or otherwise dispose of or transfer, or announce the offering
      of,
      or file any registration statement under the Securities Act in respect of,
      any
      Shares, options, rights or warrants to acquire Shares or securities exchangeable
      or exercisable for or convertible into Shares (other than as contemplated by
      this Agreement with respect to the Offered Shares) or publicly announce the
      intention to do any of the foregoing; provided,
      however,
      that
      the Company may issue (A) Shares or options to purchase Shares to unaffiliated
      third parties in connection with or pursuant to joint ventures, collaborative
      arrangements, strategic alliances or similar transactions the primary purpose
      of
      which is not for capital raising, (B) other than during the 30 days following
      the date of this Agreement, Shares to Kingsbridge Capital Limited under the
      Company’s Committed Equity Financing Facility, and (C) options to purchase
      Shares, or issue Shares upon exercise of options, pursuant to any stock option,
      stock bonus or other stock plan or arrangement described in each Applicable
      Prospectus or subsequently approved by the Company’s stockholders.
      Notwithstanding the foregoing, if (i) during the last 17 days of the Lock-up
      Period, the Company issues an earnings release or material news or a material
      event relating to the Company occurs or (ii) prior to the expiration of the
      Lock-up Period, the Company announces that it will release earnings results
      during the 16-day period beginning on the last day of the Lock-up Period, then
      in each case the Lock-up Period will be extended until the expiration of the
      18-day period beginning on the date of the issuance of the earnings release
      or
      the occurrence of the material news or material event, as applicable,
      unless
      the Placement Agent waives, in writing, such extension, except that such
      extension will not apply if, within three business days prior to the
      15th
      calendar
      day before the last day of the Lock-up Period, the Company delivers a
      certificate, signed by the Chief Financial Officer or Chief Executive Officer
      of
      the Company, certifying on behalf of the Company that (i) the Shares are
“actively traded securities” (as defined in Regulation M), (ii) the Company
      meets the applicable requirements of paragraph (a)(1) of Rule 139
      under the Securities Act in the manner contemplated by NASD Conduct
      Rule 2711(f)(4), and (iii) the provisions of NASD Conduct
      Rule 2711(f)(4) are not applicable to any research reports relating to the
      Company published or distributed by the Placement Agent during the 15 days
      before or after the last day of the Lock-up Period (before giving effect to
      such
      extension).
      The
      Company will provide the Placement
      Agent
      with
      prior notice of any such announcement that gives rise to an extension of the
      Lock-up Period. 

     

    (p)
      Investment
      Limitation.
      The
      Company shall not invest, or otherwise use the proceeds received by the Company
      from its sale of the Offered Shares in such a manner as would require the
      Company or any of its subsidiaries to register as an investment company under
      the Investment Company Act.

     

    (q)
      No
      Stabilization or Manipulation;
      Compliance with Regulation M.
      The
      Company will not take, directly or indirectly, any action designed to or that
      might be reasonably expected to cause or result in stabilization or manipulation
      of the price of the Shares or any other reference security,
      whether
      to
      facilitate the sale or resale of the Offered Shares or otherwise, and the
      Company will, and shall cause each of its affiliates to, comply with all
      applicable provisions of Regulation M. If
      the
      limitations of Rule 102 of Regulation M (“Rule
      102”)
      do not
      apply with respect to the Offered Shares or any other reference security
      pursuant to any exception set forth in Section (d) of Rule 102, then promptly
      upon notice from the Placement Agent (or, if later, at the time stated in the
      notice), the Company
      will, and shall cause each of its affiliates to,
      comply
      with Rule 102 as though such exception were not available but the other
      provisions of Rule 102 (as interpreted by the Commission) did apply.

     

    
      
        
        

      

      
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    (r)
      Existing
      Lock-Up Agreements.
      During
      the Lock-up Period, the Company will enforce all existing agreements between
      the
      Company and any of its security holders that prohibit the sale, transfer,
      assignment, pledge or hypothecation of any of the Company’s securities. In
      addition, the Company will direct the transfer agent to place stop transfer
      restrictions upon any such securities of the Company that are bound by such
      existing “lock-up” agreements for the duration of the periods contemplated in
      such agreements, including, without limitation, “lock-up” agreements entered
      into by the Company’s officers and directors pursuant to Section 7(h).

     

    The
      Placement Agent may, in its sole discretion, waive in writing the
      performance
      by the
      Company of any one or more of the foregoing covenants or extend the time for
      their performance.

     

    Section
      5. Payment
      of Expenses.
      The
      Company agrees to pay, or reimburse if paid by the Placement Agent, all costs,
      fees and expenses incurred in connection with the performance of its obligations
      hereunder and in connection with the transactions contemplated hereby, including
      without limitation (i) all expenses incident to the issuance and delivery
      of the Offered Shares (including all printing and engraving costs),
      (ii) all fees and expenses of the registrar and transfer agent of the
      Shares, (iii) all necessary issue, transfer and other stamp taxes in
      connection with the issuance and sale of the Offered Shares to the Purchasers,
      (iv) all fees and expenses of the Company’s counsel, independent public or
      certified public accountants and other advisors, (v) all costs and expenses
      incurred in connection with the preparation, printing, filing, shipping and
      distribution of the Registration Statement (including financial statements,
      exhibits, schedules, consents and certificates of experts), the Time of Sale
      Prospectus, the Prospectus, any free writing prospectus prepared by or on behalf
      of, used by, or referred to by the Company, and each preliminary prospectus,
      and
      all amendments and supplements thereto, and this Agreement, (vi) all filing
      fees, reasonable attorneys’ fees and expenses incurred by the Company or the
Placement
      Agent
      in
      connection with qualifying or registering (or obtaining exemptions from the
      qualification or registration of) all or any part of the Offered Shares for
      offer and sale under the state securities or blue sky laws, and, if requested
      by
      the Placement Agent, preparing and printing a “Blue
      Sky Survey”
or
      memorandum, and any supplements thereto, advising the Placement
      Agent
      of such
      qualifications, registrations, determinations and exemptions, which fees shall
      not exceed $5,000, (vii) the fees and expenses associated with listing
      the
      Shares on the Nasdaq Global Market, (viii) all other fees, costs and expenses
      of
      the nature referred to in Item 14 of Part II of the Registration
      Statement.
      Except
      as provided in this Section 5, Section 8, Section 9 and
      Section 10 hereof, the Placement Agent shall pay its own expenses,
      including the fees and disbursements of its counsel in excess of the amounts
      described above. 

     

    Section
      6. Covenant
      of the Placement Agent.
      The
      Placement Agent covenants with the Company not to take any action that would
      result in the Company being required to file with the Commission pursuant to
      Rule 433(d) under the Securities Act a free writing prospectus prepared by
      or on
      behalf of the Placement Agent that otherwise would not be required to be filed
      by the Company thereunder, but for the action of the Placement
      Agent.

     

    
      
        
        

      

      
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    Section
      7. Conditions
      of the Obligations of the Placement
      Agent.
      The
      obligations of the Placement Agent hereunder and the Purchasers under the
      Subscription Agreements, shall be subject to the accuracy of the representations
      and warranties on the part of the Company set forth in Section 2 hereof as
      of the date hereof and as of the Closing Date as though then made, to the timely
      performance by the Company of its covenants and other obligations hereunder,
      and
      to each of the following additional conditions:

     

    (a) 
      Accountants’
      Comfort Letter;
      Chief
      Financial Officer Certificate.
      On the
      date hereof, the Placement Agent shall have received from Ernst & Young LLP,
      independent public or certified public accountants for the Company, (i) a
      letter dated the date hereof addressed to the Placement Agent, in form and
      substance satisfactory to the Placement Agent, containing statements and
      information of the type ordinarily included in accountant’s “comfort letters” to
      underwriters, delivered according to Statement of Auditing Standards No. 72
      (or
      any successor bulletin), with respect to the audited and unaudited financial
      statements and certain financial information contained in the Registration
      Statement, Time of Sale Prospectus, and each free writing prospectus, if any,
      and, with respect to each letter dated the date hereof only, the Prospectus,
      and
      (ii) confirming that they are (A) independent public or certified public
      accountants as required by the Securities Act and the Exchange Act and (B)
      in
      compliance with the applicable requirements relating to the qualification of
      accountants under Rule 2-01 of Regulation S-X. On
      the
      date hereof, the Company shall have furnished to the Placement Agent a
      certificate, dated the date hereof, of its Chief Financial Officer in the form
      set forth in Exhibit
      E
      attached
      hereto.

     

    (b)
      Compliance
      with Registration Requirements; No Stop Order; No Objection from
      NASD.
      For
      the
      period from and after effectiveness of this Agreement and prior to the Closing
      Date:

     

    (i)  the
      Company shall have filed the Prospectus with the Commission (including the
      information previously omitted from the Registration Statement pursuant to
      Rule
      430B under the Securities Act) in the manner and within the time period required
      by Rule 424(b) under the Securities Act; or the Company shall have filed a
      post-effective amendment to the Registration Statement containing the
      information previously omitted pursuant to such Rule 430B, and such
      post-effective amendment shall have become effective;

     

    (ii)  no
      stop
      order suspending the effectiveness of the Registration Statement, any
      Rule 462(b) Registration Statement, or any post-effective amendment to the
      Registration Statement, shall be in effect and no proceedings for such purpose
      shall have been instituted or threatened by the Commission; and

     

    (iii)  the
      NASD
      shall have raised no objection to the fairness and reasonableness of the
      compensation allowable or payable to the Placement Agent as described in the
      Prospectus.

     

    (c) 
      No
      Material Adverse Change or Ratings Agency Change.
      For the
      period from and after the date of this Agreement and through and including
      the
      Closing Date, in the judgment of the Placement Agent there shall not have
      occurred any Material Adverse Change.

     

    
      
        
        

      

      
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    (d)
      Opinion
      of Counsel for the Company.
      On the
      Closing Date the Placement Agent shall have received (i) the opinion of
      Dickstein Shapiro LLP, corporate counsel for the Company, dated as of such
      Closing Date, the form of which is attached as Exhibit A
      and to
      such further effect as counsel for the Placement Agent shall reasonably request
      and (ii) the opinion of Drinker,
      Biddle & Reath LLP, intellectual property counsel
      for the Company, dated as of such Closing Date, the form of which is attached
      as
Exhibit B
      and to
      such further effect as counsel for the Placement Agent shall reasonably request.
      

     

    (e)
      Opinion
      of Counsel for the Placement
      Agent.
      On the
      Closing Date the Placement Agent shall have received the opinion of Goodwin
      Procter LLP, counsel for the Placement Agent, in form and substance satisfactory
      to the Placement Agent, dated as of the Closing Date.

     

    (f)
      Officers’
      Certificate.
      On the
      Closing Date the Placement Agent shall have received a written certificate
      executed by the Chief Executive Officer or President of the Company and the
      Chief Financial Officer of the Company, on behalf of the Company, dated as
      of
      such Closing Date, to the effect set forth in subsections (b)(ii) of this
      Section 7, and further to the effect that:

     

    (i)  for
      the
      period from and including the date of this Agreement through and including
      such
      Closing Date, there has not occurred any Material Adverse Change;

     

    (ii)  the
      representations, warranties and covenants of the Company set forth in
      Section 2 of this Agreement are true and correct with the same force and
      effect as though expressly made on and as of such Closing Date;
      and

     

    (iii)  the
      Company has complied with all the agreements hereunder and satisfied all the
      conditions on its part to be performed or satisfied hereunder at or prior to
      such Closing Date.

     

    (g)
      Bring-down
      Comfort Letter;
      Bring-down Chief Financial Officer Certificate.
      On the
      Closing Date the Placement Agent shall have received from Ernst & Young LLP,
      independent public or certified public accountants for the Company, a letter
      dated such date, in form and substance satisfactory to the Placement Agent,
      to
      the effect that they reaffirm the statements made in the letter furnished by
      them pursuant to subsection (a) of this Section 7, except that the
      specified date referred to therein for the carrying out of procedures shall
      be
      no more than three business days prior to the Closing Date. On the Closing
      Date,
      the
      Company shall have furnished to the Placement Agent a certificate, dated the
      date hereof, of its Chief Financial Officer in the form set forth in
Exhibit F
      attached
      hereto.

     

    (h)Subscription
      Agreements.
      The
      Company shall have entered into the Subscription Agreements with each of the
      Purchasers and such agreements shall be in full force and effect.

     

    (i)Escrow
      Agreement.
      The
      Company shall have entered into the Escrow Agreement and such agreement shall
      be
      in full force and effect.

     

    (j)Lock-Up
      Agreement from Certain Securityholders of the Company.
      On or
      prior to the date hereof, the Company shall have furnished to the Placement
      Agent an agreement in the form of Exhibit D
      hereto
      from the persons listed on Exhibit
      C
      hereto,
      and
      such agreement shall be in full force and effect on the Closing
      Date.

     

    
      
        
        

      

      
        21

        
          

        

      

      
        
        

      

    

     

    (k)
      Rule 462(b)
      Registration Statement.
      In the
      event that a Rule 462(b) Registration Statement is filed in connection with
      the offering contemplated by this Agreement, such Rule 462(b) Registration
      Statement shall have been filed with the Commission on the date of this
      Agreement and shall have become effective automatically upon such
      filing.

     

    (k)
      Additional
      Documents.
      On or
      before the Closing Date, the Placement Agent and counsel for the Placement
      Agent
      shall have received such information, documents and opinions as they may
      reasonably request for the purposes of enabling them to pass upon the issuance
      and sale of the Offered Shares as contemplated herein, or in order to evidence
      the accuracy of any of the representations and warranties, or the satisfaction
      of any of the conditions or agreements, herein contained; and all proceedings
      taken by the Company in connection with the issuance and sale of the Offered
      Shares as contemplated herein and in connection with the other transactions
      contemplated by this Agreement shall be satisfactory in form and substance
      to
      the Placement Agent and counsel for the Placement Agent.

     

    If
      any
      condition specified in this Section 7 is not satisfied when and as required
      to
      be satisfied, this Agreement may be terminated by the Placement Agent by notice
      to the Company at any time on or prior to the Closing Date, which termination
      shall be without liability on the part of any party to any other party, except
      that Section 5, Section 7 and Section 9 shall at all times be
      effective and shall survive such termination.

     

    Section
      8. Reimbursement
      of Placement Agent’s Expenses.
      If this
      Agreement is terminated by the Placement Agent pursuant to Section 7 or
      Section 11, or if the sale of the Offered Shares on the Closing Date is not
      consummated because of any refusal, inability or failure on the part of the
      Company to perform any agreement herein or to comply with any provision hereof,
      the Company agrees to reimburse the Placement Agent upon demand for all
      reasonable out-of-pocket expenses that shall have been reasonably incurred
      by
      the Placement Agent in connection with the proposed purchase and the offering
      and sale of the Offered Shares, including but not limited to fees and
      disbursements of counsel, printing expenses, travel expenses, postage, facsimile
      and telephone charges. 

     

    Section
      9. Indemnification.

     

    (a)
      Indemnification
      of the Placement
      Agent.
      The
      Company agrees to indemnify and hold harmless the Placement Agent, its officers
      and employees, affiliates, members, agents, directors, officers and
      representatives, and each person, if any, who controls the Placement Agent
      within the meaning of the Securities Act or the Exchange Act (collectively
      the
“Placement
      Agent Indemnified Parties,”
and
      each a “Placement
      Agent Indemnified Party”)
      against any loss, claim, damage, liability or expense, as incurred, to which
      such Placement Agent Indemnified
      Party may become subject, under the Securities Act, the Exchange Act, other
      federal or state statutory law or regulation or
      at
      common law or otherwise (including in settlement of any litigation, if such
      settlement is effected in accordance with this Agreement), insofar as such
      loss,
      claim, damage, liability or expense (or actions in respect thereof as
      contemplated below) arises out of or is based upon
      (i) any
      untrue statement or alleged untrue statement of a material fact contained in
      the
      Registration Statement, or any amendment thereto, including any information
      deemed to be a part thereof pursuant to Rule 430B under the Securities Act,
      or the omission or alleged omission therefrom of a material fact required to
      be
      stated therein or necessary to make the statements therein not misleading;
      or
      (ii) any untrue statement or alleged untrue statement of a material fact
      contained in any preliminary prospectus, the
      Time
      of Sale Prospectus, any free writing prospectus that the Company has used,
      referred to or filed, or is required to file, pursuant to Rule 433(d) of the
      Securities Act
      or the
      Prospectus (or any amendment or supplement thereto),
      or the
      omission or alleged omission therefrom of a material fact necessary in order
      to
      make the statements therein, in the light of the circumstances under which
      they
      were made, not misleading; or (iii) any act or failure to act or any alleged
      act
      or failure to act by the Placement Agent Indemnified Parties in connection
      with,
      or relating in any manner to, the Shares or the offering contemplated hereby,
      and which is included as part of or referred to in any loss, claim, damage,
      liability or action arising out of or based upon any matter covered by clause
      (i) or (ii) above, provided that the Company shall not be liable under this
      clause (iii) to the extent that a court of competent jurisdiction shall have
      determined by a final judgment that such loss, claim, damage, liability or
      action resulted directly from any such acts or failures to act undertaken or
      omitted to be taken by the Placement Agent through its bad faith or willful
      misconduct;
      and to
      reimburse the Placement Agent Indemnified Parties for any and all reasonable
      expenses (including the fees and disbursements of counsel chosen by the
      Placement Agent) as such expenses are incurred by the Placement Agent or such
      officer, employee or controlling person in connection with investigating,
      defending, settling, compromising or paying any such loss, claim, damage,
      liability, expense or action; provided, however, that the foregoing indemnity
      agreement shall not apply to any loss, claim, damage, liability or expense
      to
      the extent, but only to the extent, arising out of or based upon any untrue
      statement or alleged untrue statement or omission or alleged omission made
      in
      reliance upon and in conformity with written information furnished to the
      Company by the Placement Agent expressly for use in the Registration Statement,
      any preliminary prospectus, the Time of Sale Prospectus, any such free writing
      prospectus or the Prospectus (or any amendment or supplement thereto), it being
      understood and agreed that the only such information furnished by the Placement
      Agent to the Company consists of the information described in subsection (b)
      below; provided,
      further, that with respect to the preliminary prospectus only and not any free
      writing prospectus or any other writing or instrument, the foregoing indemnity
      agreement shall not inure to the benefit of the Placement Agent Indemnified
      Parties from whom the person asserting any loss, claim, damage, liability or
      expense purchased Offered Shares, if a copy of the Time of Sale Prospectus
      or
      the Prospectus (in each case, as then amended or supplemented if the Company
      shall have furnished any amendments or supplements thereto) was not sent or
      given by or on behalf of the Placement Agent to such person, if required by
      law
      so to have been delivered, at or prior to the written confirmation of the sale
      of the Offered Shares to such person, and if the Time of Sale Prospectus or
      the
      Prospectus (in each case, as so amended or supplemented), as applicable, would
      have cured the defect giving rise to such loss, claim, damage, liability or
      expense, unless such failure is the result of noncompliance by the Company
      with
      Section 4(a) hereof.
      The
      indemnity agreement set forth in this Section 9(a) shall be in addition to
      any liabilities that the Company may otherwise have. 

     

    
      
        
        

      

      
        22

        
          

        

      

      
        
        

      

    

     

    (b)
      Indemnification
      of the Company, its Directors and Officers.
      The
      Placement Agent agrees to indemnify and hold harmless the Company, each of
      its
      directors, each of its officers who signed the Registration Statement and each
      person, if any, who controls the Company within the meaning of the Securities
      Act or the Exchange Act, against any loss, claim, damage, liability or expense,
      as incurred, to which the Company, or any such director, officer or controlling
      person may become subject, under the Securities Act, the Exchange Act, or other
      federal or state statutory law or regulation, or at common law or otherwise
      (including in settlement of any litigation,
      if such
      settlement is effected with the written consent of the Placement
      Agent), insofar as such loss, claim, damage, liability or expense (or actions
      in
      respect thereof as contemplated below) arises out of or is based upon any untrue
      statement or alleged untrue statement of a material fact contained in the
      Registration Statement, any preliminary prospectus the
      Time
      of Sale Prospectus, any free writing prospectus that the Company has used,
      referred to or filed, or is required to file, pursuant to Rule 433(d) of the
      Securities Act
      or the
      Prospectus (or such amendment or supplement thereto), or arises out of or is
      based upon the omission or alleged omission to state therein a material fact
      required to be stated therein or necessary to make the statements therein not
      misleading, in each case to the extent, but only to the extent, that such untrue
      statement or alleged untrue statement or omission or alleged omission was made
      in the Registration Statement, such preliminary prospectus, the
      Time
      of Sale Prospectus, such free writing prospectus that the Company has used,
      referred to or filed, or is required to file, pursuant to Rule 433(d) of the
      Securities Act,
      the
      Prospectus (or such amendment or supplement thereto), in reliance upon and
      in
      conformity with written information furnished to the Company by the Placement
      Agent expressly for use therein; and to reimburse the Company, or any such
      director, officer or controlling person for any and all reasonable expenses
      (including
      the fees and disbursements of counsel chosen by the Company, or any such
      director, officer or controlling person, as applicable) as such expenses are
      incurred
      by the Company, or any such director, officer or controlling person in
      connection with investigating, defending, settling, compromising or paying
      any
      such loss, claim, damage, liability, expense or action. The Company hereby
      acknowledges that the only information that the Placement Agent has furnished
      to
      the Company expressly for use in the Registration Statement, any preliminary
      prospectus, the
      Time
      of Sale Prospectus, any free writing prospectus that the Company has filed,
      or
      is required to file, pursuant to Rule 433(d) of the Securities Act
      or the
      Prospectus (or any amendment or supplement thereto) are the statements set
      forth
in
      the
      last paragraph on the cover page of the Prospectus concerning the terms of
      the
      offering by the Placement Agent and the statements concerning the Placement
      Agent contained in the first paragraph under the caption “Plan of Distribution”.
      The indemnity agreement set forth in this Section 9(b) shall be in addition
      to any liabilities that the Placement Agent may otherwise have.

     

    
      
        
        

      

      
        23

        
          

        

      

      
        
        

      

    

     

    (c)
      Notifications
      and Other Indemnification Procedures.
      Promptly after receipt by an indemnified party under this Section 9 of
      notice of the commencement of any action, such indemnified party will, if a
      claim in respect thereof is to be made against an indemnifying party under
      this
      Section 9, notify the indemnifying party in writing of the commencement
      thereof, but the omission so to notify the indemnifying party will not relieve
      it from any liability which it may have to any indemnified party for
      contribution or otherwise than under the indemnity agreement contained in this
      Section 9 or to the extent it is not materially prejudiced as a proximate
      result of such failure. In case any such action is brought against any
      indemnified party and such indemnified party seeks or intends to seek indemnity
      from an indemnifying party, the indemnifying party will be entitled to
      participate in, and, to the extent that it shall elect, jointly with all other
      indemnifying parties similarly notified, by written notice delivered to the
      indemnified party promptly after receiving the aforesaid notice from such
      indemnified party, to assume the defense thereof with counsel reasonably
      satisfactory to such indemnified party; provided, however, if the defendants
      in
      any such action include both the indemnified party and the indemnifying party
      and the indemnified party shall have reasonably concluded that a conflict may
      arise between the positions of the indemnifying party and the indemnified party
      in conducting the defense of any such action or that there may be legal defenses
      available to it and/or other indemnified parties which are different from or
      additional to those available to the indemnifying party, the indemnified party
      or parties shall have the right to select separate counsel to assume such legal
      defenses and to otherwise participate in the defense of such action on behalf
      of
      such indemnified party or parties. Upon receipt of notice from the indemnifying
      party to such indemnified party of such indemnifying party’s election so to
      assume the defense of such action and approval by the indemnified party of
      counsel, the indemnifying party will not be liable to such indemnified party
      under this Section 9 for any legal or other expenses subsequently incurred
      by such indemnified party in connection with the defense thereof unless
      (i) the indemnified party shall have employed separate counsel in
      accordance with the proviso to the preceding sentence (it being understood,
      however, that the indemnifying party shall not be liable for the fees and
      expenses of more than one separate counsel (together with local counsel),
      representing the indemnified parties who are parties to such action)
      , which
      counsel (together with any local counsel) for the indemnified parties shall
      be
      selected by the Placement Agent (in the case of counsel for the indemnified
      parties referred to in Section 9(a) above) or by the Company (in the case
      of counsel for the indemnified parties referred to in Section 9(b)
      above))
      or
      (ii) the indemnifying party shall not have employed counsel satisfactory to
      the indemnified party to represent the indemnified party within a reasonable
      time after notice of commencement of the action, in each of which cases the
      fees
      and expenses of counsel shall be at the expense of the indemnifying party and
      shall be paid as they are incurred.

     

    
      
        
        

      

      
        24

        
          

        

      

      
        
        

      

    

     

    (d)
      Settlements.
      The
      indemnifying party under this Section 9 shall not be liable for any
      settlement of any proceeding effected without its written consent, but if
      settled with such consent or if there be a final judgment for the plaintiff,
      the
      indemnifying party agrees to indemnify the indemnified party against any loss,
      claim, damage, liability or expense by reason of such settlement or judgment.
      Notwithstanding the foregoing sentence, if at any time an indemnified party
      shall have requested an indemnifying party to reimburse the indemnified party
      for fees and expenses of counsel as contemplated by Section 9(c) hereof,
      the indemnifying party agrees that it shall be liable for any settlement of
      any
      proceeding effected without its written consent if (i) such settlement is
      entered into more than 30 days after receipt by such indemnifying party of
      the aforesaid request and (ii) such indemnifying party shall not have
      reimbursed the indemnified party in accordance with such request prior to the
      date of such settlement. No indemnifying party shall, without the prior written
      consent of the indemnified party, effect any settlement, compromise or consent
      to the entry of judgment in any pending or threatened action, suit or proceeding
      in respect of which any indemnified party is or could have been a party and
      indemnity was or could have been sought hereunder by such indemnified party,
      unless such settlement, compromise or consent (i) includes an unconditional
      release of such indemnified party from all liability on claims that are the
      subject matter of such action, suit or proceeding and (ii) does not include
      a
      statement as to or an admission of fault, culpability or any failure to act,
      by
      or on behalf of the indemnified party. 

     

    Section
      10. Contribution.If
      the
      indemnification provided for in Section 9 is for any reason held to be
      unavailable to or otherwise insufficient to hold harmless an indemnified party
      in respect of any losses, claims, damages, liabilities or expenses referred
      to
      therein, then each indemnifying party shall contribute to the aggregate amount
      paid or payable by such indemnified party, as incurred, as a result of any
      losses, claims, damages, liabilities or expenses referred to therein (i) in
      such proportion as is appropriate to reflect the relative benefits received
      by
      the Company, on the one hand, and the Placement Agent, on the other hand, from
      the offering of the Offered Shares pursuant to this Agreement or (ii) if
      the allocation provided by clause (i) above is not permitted by applicable
      law, in such proportion as is appropriate to reflect not only the relative
      benefits referred to in clause (i) above but also the relative fault of the
      Company, on the one hand, and the Placement Agent, on the other hand, in
      connection with the statements or omissions which resulted in such losses,
      claims, damages, liabilities or expenses, as well as any other relevant
      equitable considerations. The relative benefits received by the Company, on
      the
      one hand, and the Placement Agent, on the other hand, in connection with the
      offering of the Offered Shares pursuant to this Agreement shall be deemed to
      be
      in the same respective proportions as the total net proceeds from the offering
      of the Offered Shares pursuant to this Agreement (after deducting the aggregate
      placement agent’s fee but before deducting expenses) received by the Company,
      and the aggregate placement agent’s fee received by the Placement Agent, in each
      case as set forth on the front cover page of the Prospectus bear to the
      aggregate public offering price of the Offered Shares as set forth on such
      cover. The relative fault of the Company, on the one hand, and the Placement
      Agent, on the other hand, shall be determined by reference to, among other
      things, whether any such untrue or alleged untrue statement of a material fact
      or omission or alleged omission to state a material fact relates to information
      supplied by the Company, on the one hand, or the Placement Agent, on the other
      hand, and the parties’ relative intent, knowledge, access to information and
      opportunity to correct or prevent such statement or omission.

     

    
      
        
        

      

      
        25

        
          

        

      

      
        
        

      

    

     

    The
      amount paid or payable by a party as a result of the losses, claims, damages,
      liabilities and expenses referred to above shall be deemed to include, subject
      to the limitations set forth in Section 9(c), any legal or other fees or
      expenses reasonably incurred by such party in connection with investigating
      or
      defending any action or claim. The provisions set forth in Section 9(c)
      with respect to notice of commencement of any action shall apply if a claim
      for
      contribution is to be made under this Section 10; provided,
      however,
      that no
      additional notice shall be required with respect to any action for which notice
      has been given under Section 9(c) for purposes of
      indemnification.

     

    The
      Company and the Placement Agent agree that it would not be just and equitable
      if
      contribution pursuant to this Section 10 were determined by pro rata
      allocation or by any other method of allocation which does not take account
      of
      the equitable considerations referred to in this Section 10.

     

    Notwithstanding
      the provisions of this Section 10, the Placement Agent shall not be
      required to contribute any amount in excess of the aggregate placement agent’s
      fee received by the Placement Agent in connection with the Offered Shares.
      No
      person guilty of fraudulent misrepresentation (within the meaning of
      Section 12(f) of the Securities Act) shall be entitled to contribution from
      any person who was not guilty of such fraudulent misrepresentation. For purposes
      of this Section 10, each Placement Agent Indemnified Party shall have the
      same rights to contribution as the Placement Agent, and each director of the
      Company, each officer of the Company who signed the Registration Statement,
      and
      each person, if any, who controls the Company with the meaning of the Securities
      Act and the Exchange Act shall have the same rights to contribution as the
      Company.

     

    Section
      11. Termination
      of this Agreement. Prior
      to
      the purchase of the Offered Shares by the Purchasers on the Closing Date this
      Agreement may be terminated by the Placement Agent by notice given to the
      Company if at any time: (i) trading or quotation in any of the Company’s
      securities shall have been suspended or limited by the Commission or by the
      Nasdaq Global Market,
      or
      trading in securities generally on either the Nasdaq Stock Market or the New
      York Stock Exchange shall have been suspended or limited, or minimum or maximum
      prices shall have been generally established on any of such stock exchanges
      by
      the Commission or the NASD; (ii) a general banking moratorium shall have
      been declared by any of federal or New York; (iii) there shall have
      occurred any outbreak or escalation of national or international hostilities
      or
      any crisis or calamity, or any change in the United States or international
      financial markets, or any substantial change or development involving a
      prospective substantial change in United States’ or international political,
      financial or economic conditions, as in the judgment of the Placement Agent
      is
      material and adverse and makes it impracticable to market the Offered Shares
      in
      the manner and on the terms described in the Time of Sale Prospectus or to
      enforce contracts for the sale of securities; (iv) in the judgment of the
      Placement Agent there shall have occurred any Material Adverse Change; or (v)
      the Company shall have sustained a loss by strike, fire, flood, earthquake,
      accident or other calamity of such character as in the judgment of the Placement
      Agent may interfere materially with the conduct of the business and operations
      of the Company regardless of whether or not such loss shall have been insured.
      Any termination pursuant to this Section 11 shall be without liability on
      the part of (a) the Company to the Placement Agent, except that the Company
      shall be obligated to reimburse the expenses of the Placement Agent pursuant
      to
      Sections 5 and 8 hereof, (b)  the Placement Agent to the Company,
      or (c) of any party hereto to any other party except that the provisions of
      Section 9 and Section 10 shall at all times be effective and shall
      survive such termination.

     

    
      
        
        

      

      
        26

        
          

        

      

      
        
        

      

    

     

    Section
      12. No
      Advisory or Fiduciary Relationship. The
      Company acknowledges and agrees that (a) the purchase and sale of the Offered
      Shares by the Purchasers, including the determination of the public offering
      price of the Offered Shares and any related discounts and commissions, is an
      arm’s-length commercial transaction between the Company, on the one hand, and
      the Placement Agent, on the other hand, (b) in connection with the offering
      contemplated hereby and the process leading to such transaction the Placement
      Agent is and has been acting solely as a principal and is not the agent or
      fiduciary of the Company, or its stockholders, creditors, employees or any
      other
      party, (c) the Placement Agent has
      not
      assumed or will not assume an advisory or fiduciary responsibility in favor
      of
      the Company with respect to the offering contemplated hereby or the process
      leading thereto (irrespective of whether the Placement Agent has advised or
      is
      currently advising the Company on other matters) and the Placement Agent has
      no
      obligation to the Company with respect to the offering contemplated hereby
      except the obligations expressly set forth in this Agreement, (d) the Placement
      Agent and
      its
      respective affiliates may be engaged in a broad range of transactions that
      involve interests that differ from those of the Company, and (e) the Placement
      Agent has not provided any legal, accounting, regulatory or tax advice with
      respect to the offering contemplated hereby and the Company has consulted its
      own legal, accounting, regulatory and tax advisors to the extent it deemed
      appropriate 

     

    Section
      13. Representations
      and Indemnities to Survive Delivery.
      The
      respective indemnities, agreements, representations, warranties and other
      statements of the Company, of its officers and of the Placement Agent set forth
      in or made pursuant to this Agreement will remain in full force and effect,
      regardless of any investigation made by or on behalf of the Placement Agent
      or
      the Company or any of its or their partners, officers or directors or any
      controlling person, as the case may be, and, anything herein to the contrary
      notwithstanding, will survive delivery of and payment for the Offered Shares
      sold hereunder and any termination of this Agreement.

     

    Section
      14. Notices.
      All
      communications hereunder shall be in writing and shall be mailed, hand delivered
      or telecopied and confirmed to the parties hereto as follows:

     

    If
      to the
      Placement Agent:

    

    Jefferies
      & Company, Inc.

    520
      Madison Avenue

    New
      York,
      New York 10022

    Facsimile:
      (212) 284-2280 

    Attention:
      General Counsel

     

    
      
        
        

      

      
        27

        
          

        

      

      
        
        

      

    

     

    with
      a
      copy to:

    

    Goodwin
      Procter LLP

    Exchange
      Place

    Boston,
      Massachusetts 02109

    Facsimile:
      (617) 523-1231

    Attention:
      Mitchell S. Bloom, Esq.

    

    If
      to the
      Company:

    

    Discovery
      Laboratories, Inc.

    2600
      Kelly Road, Suite 100

    Warrington,
      Pennsylvania 18976

    Facsimile:
      (215)
      488-9557 

    Attention:
      John G. Cooper 

    

    and

    

    Dickstein
      Shapiro LLP

    1177
      Avenue of the Americas, 47th Floor

    New
      York,
      New York 10036-2714

    Facsimile:
      212-299-8686

    Attention:
      Ira L. Kotel, Esq.

    

    Any
      party
      hereto may change the address for receipt of communications by giving written
      notice to the others.

     

    Section
      15. Successors;
      Persons Entitled to Benefit of Agreement.
      This
      Agreement will inure to the benefit of and be binding upon the parties hereto,
      and to the benefit of the employees, officers and directors and controlling
      persons referred to in Section 9 and Section 10, and in each case
      their respective successors, and no other person will have any right or
      obligation hereunder. This Agreement shall also inure to the benefit of the
      Purchasers, and each of their respective successors and assigns, which shall
      be
      third party beneficiaries hereof. 

     

    Section
      16. Partial
      Unenforceability.
      The
      invalidity or unenforceability of any Section, paragraph or provision of this
      Agreement shall not affect the validity or enforceability of any other Section,
      paragraph or provision hereof. If any Section, paragraph or provision of this
      Agreement is for any reason determined to be invalid or unenforceable, there
      shall be deemed to be made such minor changes (and only such minor changes)
      as
      are necessary to make it valid and enforceable.

     

    Section
      17. Governing
      Law Provisions.
      This
      Agreement shall be governed by and construed in accordance with the internal
      laws of the State of New York applicable to agreements made and to be performed
      in such state. Any legal suit, action or proceeding arising out of or based
      upon
      this Agreement or the transactions contemplated hereby may be instituted in
      the
      federal courts of the United States of America located in the Borough of
      Manhattan in the City of New York or the courts of the State of New York in
      each
      case located in the Borough of Manhattan in the City of New York (collectively,
      the “Specified
      Courts”),
      and
      each party irrevocably submits to the exclusive jurisdiction (except for
      proceedings instituted in regard to the enforcement of a judgment of any such
      court, as to which such jurisdiction is non-exclusive) of such courts in any
      such suit, action or proceeding. Service of any process, summons, notice or
      document by mail to such party’s address set forth above shall be effective
      service of process for any suit, action or other proceeding brought in any
      such
      court. The parties irrevocably and unconditionally waive any objection to the
      laying of venue of any suit, action or other proceeding in the Specified Courts
      and irrevocably and unconditionally waive and agree not to plead or claim in
      any
      such court that any such suit, action or other proceeding brought in any such
      court has been brought in an inconvenient forum. 

     

    
      
        
        

      

      
        28

        
          

        

      

      
        
        

      

    

     

    Section
      18. General
      Provisions.
      This
      Agreement constitutes the entire agreement of the parties to this Agreement
      and
      supersedes all prior written or oral and all contemporaneous oral agreements,
      understandings and negotiations with respect to the subject matter hereof.
      This
      Agreement may be executed in two or more counterparts, each one of which shall
      be an original, with the same effect as if the signatures thereto and hereto
      were upon the same instrument. This Agreement may not be amended or modified
      unless in writing by all of the parties hereto, and no condition herein (express
      or implied) may be waived unless waived in writing by each party whom the
      condition is meant to benefit. The Table of Contents and the Section headings
      herein are for the convenience of the parties only and shall not affect the
      construction or interpretation of this Agreement.

     

    Each
      of
      the parties hereto acknowledges that it is a sophisticated business person
      who
      was adequately represented by counsel during negotiations regarding the
      provisions hereof, including, without limitation, the indemnification provisions
      of Section 9 and the contribution provisions of Section 10, and is
      fully informed regarding said provisions. Each of the parties hereto further
      acknowledges that the provisions of Sections 9 and 10 hereto fairly
      allocate the risks in light of the ability of the parties to investigate the
      Company, its affairs and its business in order to assure that adequate
      disclosure has been made in the Registration Statement, any preliminary
      prospectus, the Time of Sale Prospectus, each free writing prospectus and the
      Prospectus (and any amendments and supplements thereto), as required by the
      Securities Act and the Exchange Act.

     

    [Remainder
      of Page Intentionally Left Blank.]

     

    
      
        
        

      

      
        29

        
          

        

      

      
        
        

      

    

     

    Exhibit
      10.1

     

     

    If
      the
      foregoing is in accordance with your understanding of our agreement, kindly
      sign
      and return to the Company the enclosed copies hereof, whereupon this instrument,
      along with all counterparts hereof, shall become a binding agreement in
      accordance with its terms.

    
      	 	 	 
	 	
              Very
                truly yours,

              DISCOVERY
                LABORATORIES, INC.

            
	 
 	 
 	 
 
	 	By:  	
              /s/
                David Lopez

            
	 	
              
Name:
              David Lopez
	 	Title:
              EVP
	 	 

    

    
    

    The
      foregoing Placement Agency Agreement is hereby confirmed and accepted by the
      Placement Agent in New York, New York as of the date first above
      written.

    
      	 	 	 	 
	 	 	 	 
	JEFFERIES & COMPANY,
              INC.	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	By: 	
              /s/
                Mark Sahler

            	 	 	 
	 	
              
Name:
Mark
              Sahler	 	 	
            
	 	Title:
First
              Vice President	 	 	 

    

     

    [Signature
      Page to Placement Agency Agreement]

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    SCHEDULE
      A

     

     

    Schedule
      of Free Writing Prospectuses included in the Time of Sale
      Prospectus:

     

     

    Filed
      Pursuant to Rule 433

    Issuer
      Free Writing Prospectus dated December 7, 2007

    Relating
      to Prospectus dated October 11, 2005

    Registration
      No. 333-128929

    

     

    

    Up
      to
      10,000,000 Shares

     

    Discovery
      Laboratories, Inc.

     

    Common
      Stock 

     

    ISSUER
      FREE WRITING PROSPECTUS 

     

    
      	
              Issuer:

            	 	
              Discovery
                Laboratories, Inc.

            
	 	 	 
	
              Ticker
                / Exchange:

            	 	
              DSCO
                / Nasdaq Global Market

            
	 	 	 
	
              Offering
                size:

            	 	
              Up
                to 10,000,000 shares

            
	 	 	 
	
              Public
                offering price:

            	 	
              $2.50

            
	 	 	 
	
              Net
                proceeds to Issuer:

            	 	
              We
                expect the net proceeds from this offering of common stock to be
                up to
                approximately $23,590,000 after deducting the estimated placement
                agent’s
                fees and estimated offering expenses.

            
	 	 	 
	
              Use
                of Proceeds:

            	 	
              Except
                as described in any prospectus supplement or post effective amendment,
                we
                currently anticipate using the net proceeds from the sale of our
                common
                stock primarily for:

               

              ·  Preparing
                for the anticipated U.S. commercial launch of Surfaxin®
                for Respiratory Distress Syndrome in premature infants, including
                establishing our own U.S. commercial sales and marketing organization
                specialized in neonatal and pediatric indications, enhancing our
                medical
                affairs capabilities with medical science liaison personnel deployed
                throughout the U.S. and enhancing our manufacturing, compliance and
                regulatory capabilities;

               

              ·  Pursuing
                potential collaboration arrangements with international partners
                to
                co-develop and/or co-commercialize our neonatal and pediatric pipeline
                for
                Surfaxin and AerosurfTM, and potential world-wide strategic alliances for
                the development and/or commercialization of our novel Surfaxin Replacement
                Therapy (SRT) for respiratory conditions and disorders affecting
                adult
                patients;

               

              ·  Research,
                development and clinical trial activities associated with ongoing
                development of Aerosurf, including development and manufacture of
                a
                second-generation aerosolization system that will potentially be
                used in
                anticipated Phase 2b/3 clinical trials for treatment of respiratory
                conditions prevalent in the NICU and PICU and, if approved, in the
                commercial market;

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	 	 	
              ·  Clinical
                trial costs associated with conducting clinical trials in 2008 and
                into
                2009, including our ongoing Phase 2 and anticipated Phase 3 clinical
                trials for Surfaxin for the treatment of Acute Respiratory Failure
                and our
                anticipated Phase 2b/3 clinical trials for Surfaxin for the prevention
                of
                Bronchopulmonary Dysplasia; and 

               

              ·  Exploratory
                development of our aerosolized SRT platform in other disease targets,
                such
                as Acute Lung Injury and Cystic Fibrosis.

               

              The
                amounts and timing of the expenditures may vary significantly depending
                on
                numerous factors, such as the progress of our research and development
                efforts, technological advances and the competitive environment for
                Surfaxin and our other SRT drug candidates and their intended uses.
                Pending the application of the net proceeds, we are investing the
                proceeds
                in short-term, interest-bearing instruments or other investment-grade
                securities.

            
	 	 	 
	
              Trade
                date:

            	 	
              December
                7, 2007

            
	 	 	 
	
              Settlement
                date:

            	 	
              December
                12, 2007

            
	 	 	 
	
              Placement
                Agent:

            	 	
              Jefferies
                & Company, Inc.

            

    

     

    THE
      ISSUER HAS FILED A REGISTRATION STATEMENT (INCLUDING A PROSPECTUS) WITH THE
      SEC
      FOR THE OFFERING TO WHICH THIS COMMUNICATION RELATES BEFORE YOU INVEST, YOU
      SHOULD READ THE PROSPECTUS IN THAT REGISTRATION STATEMENT AND OTHER DOCUMENTS
      THE ISSUER HAS FILED WITH THE SEC FOR MORE COMPLETE INFORMATION ABOUT THE ISSUER
      AND THIS OFFERING. YOU MAY GET THESE DOCUMENTS FOR FREE BY VISITING EDGAR ON
      THE
      SEC WEB SITE AT WWW.SEC.GOV. ALTERNATIVELY, THE ISSUER, THE PLACEMENT AGENT
      OR
      ANY DEALER PARTICIPATING IN THE OFFERING WILL ARRANGE TO SEND YOU THE PROSPECTUS
      IF YOU REQUEST IT BY CALLING TOLL-FREE 1-888-449-2342.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      A

     

     

    Opinion
      of corporate counsel for the Company to be delivered pursuant to
      Section 7(d)(i) of the Placement Agency Agreement.

     

    i. The
      Company validly exists under the laws of the State of Delaware, with corporate
      power and authority to own, lease and operate its properties and to conduct
      its
      business as described or incorporated by reference in the Prospectus Supplement
      and to enter into and perform its obligations under the Placement Agency
      Agreement and the Subscription Agreement.

     

    ii. The
      Company is in good standing under the laws of the State of Delaware and is
      qualified to do business and is in good standing as a foreign corporation in
      the
      State of California and the Commonwealth of Pennsylvania.

     

    iii. The
      authorized, issued and outstanding capital stock of the Company (including
      the
      Shares) conforms to the descriptions thereof set forth or incorporated by
      reference in the Prospectus Supplement.

     

    iv. No
      stockholder of the Company or any other person has any preemptive right, right
      of first refusal or other similar right to subscribe for or purchase securities
      of the Company (i) arising by operation of the Restated Certificate of
      Incorporation, as amended, or by-laws of the Company or the General Corporation
      Law of the State of Delaware or (ii) to our knowledge, otherwise.

     

    v. The
      Placement Agency Agreement and the Subscription Agreements have been duly
      authorized, executed and delivered by the Company.

     

    vi. The
      Shares to be purchased by the Purchasers from the Company have been duly
      authorized for issuance and sale pursuant to the Subscription Agreements and,
      when issued and delivered by the Company pursuant to the Subscription Agreements
      against payment of the consideration set forth therein, will be validly issued,
      fully paid and nonassessable.

     

    vii. The
      Registration Statement has been declared effective by the Commission under
      the
      Securities Act. To our knowledge, no stop order suspending the effectiveness
      of
      either of the Registration Statement or the Rule 462(b) Registration Statement,
      if any, has been issued under the Securities Act and no proceedings for such
      purpose have been instituted or are pending or are contemplated or threatened
      by
      the Commission. Any required filing of the Prospectus and any supplement thereto
      pursuant to Rule 424(b) under the Securities Act has been made in the manner
      and
      within the time period required by such Rule 424(b).

     

    viii. The
      statements (i) in the Time of Sale Prospectus under the captions “Risk
      Factors--Provisions of our Restated Certificate of Incorporation, Shareholders
      Rights Agreement and Delaware law could defer a change of our management which
      could discourage or delay offers to acquire us,” “Preferred Stock” and “Common
      Stock,” and (ii) in the Registration Statement in Item 15, in each case insofar
      as such statements purport to describe matters of law or certain provisions
      of
      documents, instruments, agreements, statutes or regulations referred to therein,
      are accurate in all material respects.

     

    
      
        
        

      

      
        A-1

        
          

        

      

      
        
        

      

    

     

    ix. To
      our
      knowledge, there are no legal or governmental actions, suits or proceedings
      pending or threatened against the Company which are required to be disclosed
      in
      the Registration Statement, other than those disclosed therein.

     

    x. To
      our
      knowledge, there are no persons with registration or other similar rights to
      have any debt or equity securities registered for sale under the Registration
      Statement or included in the offering contemplated by the Placement Agency
      Agreement, except for such rights as have been duly waived.

     

    xi. The
      execution and delivery of the Placement Agency Agreement and the Subscription
      Agreements by the Company, and the performance by the Company of its obligations
      under such agreements (other than performance by the Company of its
      indemnification obligations, as to which no opinion is rendered) will not result
      in any(i) violation of the provisions of the Restated Certificate of
      Incorporation, as amended, or by-laws of the Company; (ii) conflict with or
      result in a breach of any of the terms and provisions of, or constitute a
      default (or an event which with notice or lapse of time, or both, would
      constitute a default) under, or result in the creation or imposition of any
      lien, charge or encumbrance upon any property or assets of the Company or any
      of
      its subsidiaries pursuant to, any of the agreements (the “Material Agreements”)
      that are exhibits contained in filings made by the Company pursuant to the
      Securities Exchange Act of 1934, as amended (the “Exchange Act”), and
      incorporated by reference in the Prospectus Supplement; or (iii) will not result
      in any violation of any federal or New York law or, to our knowledge any
      administrative regulation or administrative or court decree, applicable to
      the
      Company.

     

    xii. No
      consent, approval, authorization or other order of, or registration or filing
      with, any court or other governmental or regulatory authority or agency, is
      required for the consummation of the transactions contemplated by the Placement
      Agency Agreement, except such as have been obtained or made by the Company
      and
      are in full force and effect under the Securities Act, applicable state
      securities or blue sky laws or The Nasdaq Global Market.

     

    xiii. To
      our
      knowledge, the Company is not in violation of its Restated Certificate of
      Incorporation, as amended, or in default under any of the Material Agreements,
      except for such violation or default as would not, individually or in the
      aggregate, result in a Material Adverse Change.

     

    xiv. The
      Company is not, and assuming the accuracy of the section entitled “Use of
      Proceeds” in the Prospectus Supplement, after receipt of payment for the Shares
      will not be, an “investment company” within the meaning of the Investment
      Company Act of 1940.

     

    xv. Each
      document filed pursuant to the Exchange Act (other than the financial statements
      and supporting schedules included therein, as to which no opinion need be
      rendered) and incorporated or deemed to be incorporated by reference in the
      Prospectus Supplement complied when so filed as to form in all material respects
      with the Exchange Act.

     

    In
      our
      role as special counsel to the Company in connection with the preparation by
      the
      Company of the Registration Statement, the Prospectus, the Time of Sale
      Prospectus and the Prospectus Supplement, we have participated in conferences
      with officers and representatives of the Company, and counsel for the Placement
      Agent, at which time the contents of the Registration Statement, the Prospectus,
      the Time of Sale Prospectus and the Prospectus Supplement, and related matters
      were discussed. The purpose of our professional engagement was not to establish
      or confirm factual matters set forth in the Registration Statement, the
      Prospectus, the Time of Sale Prospectus and/or the Prospectus Supplement. We
      have not undertaken any obligation to verify independently any of the factual
      matters set forth therein, including the documents incorporated by reference
      therein, and any supplements or amendments thereto; moreover, many of the
      determinations required to be made in the preparation of the Registration
      Statement, the Prospectus, the Time of Sale Prospectus and/or the Prospectus
      Supplement involve matters of a non-legal issue. On the basis of the facts
      that
      we gained in the course of the foregoing and subject to the qualifications
      and
      limitations set forth herein, we confirm to you that no facts came to our
      attention that have caused us to believe that either (a) the Registration
      Statement, at the time it became effective (including the information deemed
      to
      be part of the Registration Statement at the time of effectiveness pursuant
      to
      Rule 462, Rule 430B or Rule 434, if applicable), contained or incorporated
      by
      reference any untrue statement of a material fact or omitted to state any
      material fact necessary to make the statements therein not misleading, or (b)
      the Prospectus, as of its date (or any amendment thereof or supplement thereto
      made prior to the Closing Date as of the date of such amendment or supplement),
      the Time of Sale Prospectus, as of 6:00 a.m. on December 7, 2007 (or any
      amendment thereof or supplement thereto made prior to the Closing Date as of
      the
      date of such amendment thereof or supplement thereto), or the Prospectus
      Supplement, as of the date it was filed by the Company with the Commission
      and
      as of the date and time of delivery of this letter, contained or incorporated
      by
      reference any untrue statement of a material fact or omitted to state any
      material fact necessary to make the statements therein not misleading in light
      of the circumstances under which they were made.

     

    
      
        
        

      

      
        A-2

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      B

     

     

    Opinion
      of intellectual property counsel for the Company to be delivered pursuant to
      Section 7(d)(ii) of the Placement Agency Agreement.

     

    1. Having
      reviewed the information in the 2006 Form 10-K, the 2007 Forms 10-Q and the
      2007
      Forms 8-K relating to U.S. patent matters under “Licensing Arrangements; Patents
      and Proprietary Rights,” we believe that the information contains accurate
      summaries of the patents licensed, or under option to license, to the Company
      in
      all material respects and, to the extent that it constitutes matters of law,
      summaries of legal matters or legal proceedings, or legal conclusions, fairly
      presents in all material respects the information called for with respect to
      such legal matters, documents and proceedings and fairly summarizes in all
      material respects the matters referred to therein. We have also reviewed the
      information in the Prospectus, the Prospectus Supplement, the 2006 Form 10-K,
      the 2007 Forms 10-Q and the 2007 Forms 8-K relating to U.S. patent matters
      under
“RISK FACTORS” or “Risks Related to Our Business,” as enumerated above, and to
      the extent that the information constitutes matters of law, summaries of legal
      matters or legal proceedings, or legal conclusions, we believe it fairly
      presents in all material respects the information called for with respect to
      such legal matters, documents and proceedings and fairly summarizes in all
      material respects the matters referred to therein.

     

    2. Having
      reviewed the claims of Company’s Licensed U.S. Patents, Optioned Applications
      and Owned Applications: (i) we believe that each of the Licensed U.S. Patents,
      Optioned Applications and Owned Applications claims patentable subject matter;
      (ii) to our knowledge, without any searches having been conducted or having
      been
      required to have been conducted and without having made any further
      investigation of any kind for the purpose of preparing these statements other
      than to confirm our belief with the Company, there are no legal or governmental
      proceedings pending (other than normal proceedings relating to the maintenance
      of the patents before appropriate government authorities) relating to the
      Licensed U.S. Patents, the Optioned Applications or the Owned Applications;
      and
      (iii) to our knowledge, no such material proceedings are threatened or
      contemplated by governmental authorities or others.

     

    3. Having
      reviewed the License Agreements, the Assignee Search Results and the
      Assignments, without having reviewed the Company’s employment agreements and
      without having made any further investigation of any kind for the purpose of
      preparing these statements other than to confirm our belief with the Company
      that inventors named on the Owned Applications are employees of the Company,
      we
      believe that (i) the inventions described in the Licensed U.S. Patents, Optioned
      Applications and Owned Applications are properly licensed or under option to
      license to the company, or are assigned to or under obligation of assignment
      to
      the Company; and (ii) the Company’s licensors possess record title to the
      Licensed U.S. Patents or Optioned Applications, with the following notations.
      (1) U.S. Patent 6,492,490 on its face names Ortho Pharmaceutical Corporation
      as
      assignee. The Assignee Search did not identify a recorded assignment for this
      patent, however the patent is stated on its face to be related as a divisional
      of U.S. Patent 6,013,619, for which an assignment has been recorded, such that
      it is reasonable to infer inclusion of U.S. Patent 6,492,490 in that assignment.
      (2) An assignment for Owned Application 61/001,586 has not yet been executed.
      (3) All Owned Applications except 61/001,586 are believed to be subject to
      a
      security interest to Pharmbio Development, Inc., recorded November 2, 2006
      at
      Reel 018468, Frame 0530.

     

    
      
        
        

      

      
        B-1

        
          

        

      

      
        
        

      

    

     

    4. We
      have
      no knowledge of any other facts that would preclude the Company from having
      valid and enforceable license rights or clear title to the Company's Licensed
      U.S. Patents, Optioned Applications and Owned Applications or any foreign
      counterparts thereof. In addition, based solely on our review of the licenses
      themselves and representations made by the Company, we believe that no interests
      have been conveyed to third parties, and that the Company’s licenses to the
      Licensed U.S. Patents and Optioned Applications and any foreign counterparts
      thereof are exclusive to the Company, and that all assignments of rights in
      connection with the Owned Applications, or all obligations to assign rights
      in
      the Owned Applications, are solely to the Company.

     

    5. We
      have
      no knowledge that the Company or the Company’s licensors have not complied with
      the duty of candor and disclosure requirements with the PTO and all other
      similar authorities around the world as appropriate, for each of the Licensed
      U.S. Patents, Optioned Applications and Owned Applications, and foreign
      counterparts thereof, and to the best of our knowledge, all pending Optioned
      Applications and Owned Applications are in good standing, and none has been
      finally rejected or abandoned.

     

    6. We
      are
      not aware of any basis for a finding of unenforceability or invalidity of any
      Licensed U.S. Patent, and to the best of our knowledge, without any searches
      having been conducted or having been required to have been conducted and without
      having made any further investigation of any kind for the purpose of preparing
      these statements other than to confirm our belief with the Company, neither
      the
      Company nor its licensors have received any notice of infringement of or
      conflict with rights or claims of others with respect to any Intellectual
      Property owned or used by the Company.

     

    7. We
      have
      no knowledge of any patent rights of others that are or would be infringed
      by
      specific products or processes referred to in the Prospectus, which
      infringement, singly or in the aggregate, if the subject of an unfavorable
      decision, ruling or finding, would result in any material adverse effect on
      the
      condition, financial or otherwise, or in the earnings, business or operations
      of
      the Company.

     

    8. Having
      reviewed the Patent Language contained in one or more of the Prospectus, the
      Prospectus Supplement, the 2006 Form 10-K, the 2007 Forms 10-Q and the 2007
      Forms 8-K as listed hereinabove, we have no reason to believe that the Patent
      Language, at the time it was filed with the SEC and as of the date hereof,
      contained or incorporated by reference any untrue statement of a material fact
      or omitted to state any material fact necessary to make the statements therein
      not misleading in light of the circumstances under which they were
      made.

     

    9. We
      have
      no knowledge that the Company lacks or will be unable to obtain any rights
      or
      licenses to use all Intellectual Property necessary for the conduct of its
      business as now proposed to be conducted by the Company as described in the
      Prospectus.

     

    10. We
      have
      no knowledge of any asserted or unasserted claims of any persons relating to
      the
      scope or ownership of the Licensed Patents, Optioned Applications or Owned
      Applications, nor do we have any knowledge of any liens having been filed
      against any of the Licensed Patents, Optioned Applications or Owned
      Applications.

     

    
      
        
        

      

      
        B-2

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      C

     

    

    LIST
      OF
      PERSONS EXECUTING LOCK-UPS

     

    W.
      Thomas
      Amick

    Robert
      J.
      Capetola 

    John
      G.
      Cooper 

    Antonio
      Esteve

    Max
      E.
      Link 

    David
      L.
      Lopez, Esq. 

    Herbert
      H. McDade, Jr.

    Marvin
      E.
      Rosenthale 

    Kathyrn
      Cole

    Charles
      F. Katzer

    Kathleen
      McGowan

    Thomas
      F.
      Miller

    Robert
      Segal

    Mary
      B.
      Templeton

    

    
      
        
        

      

      
        C-1

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      D

     

    

    LOCK-UP
      AGREEMENT

    

     

    December
      __, 2007

    

    Jefferies
      & Company, Inc.

    520
      Madison Avenue

    New
      York,
      New York 10022

    

    RE: Discovery
      Laboratories Inc. (the “Company”)

    

    Ladies
      & Gentlemen:

    

    The
      undersigned is an owner of record or beneficially of certain shares of common
      stock, par value $.001 per share, of the Company (“Shares”)
      or
      securities convertible into or exchangeable or exercisable for Shares. The
      Company proposes to carry out a “registered direct” public offering of Shares
      (the “Offering”)
      for
      which Jefferies & Company, Inc. (the “Representative”)
      will
      act as placement agent. The undersigned recognizes that the Offering will be
      of
      benefit to the undersigned and will benefit the Company by, among other things,
      raising additional capital for its operations. The undersigned acknowledges
      that
      the Representative is relying on the representations and agreements of the
      undersigned contained in this letter agreement in carrying out its obligations
      in connection with the Offering and in entering into a placement agency
      agreement with the Company with respect to the Offering.

    

    In
      consideration of the foregoing, the undersigned hereby agrees that the
      undersigned will not (and will cause any spouse or immediate family member
      of
      the spouse or the undersigned living in the undersigned’s household not to),
      without the prior written consent of the Representative (which consent may
      be
      withheld in its sole discretion), directly or indirectly, sell, offer, contract
      or grant any option to sell (including without limitation any short sale),
      pledge, transfer, establish an open “put equivalent position” within the meaning
      of Rule 16a-1(h) under the Securities Exchange Act of 1934, as amended, or
      otherwise dispose of any Shares, options or warrants to acquire Shares, or
      securities exchangeable or exercisable for or convertible into Shares currently
      or hereafter owned either of record or beneficially (as defined in Rule 13d-3
      under the Securities Exchange Act of 1934, as amended) by the undersigned (or
      such spouse or family member), or publicly announce an intention to do any
      of
      the foregoing, for a period commencing on the date hereof and continuing through
      the close of trading on the date 60 days after the date of the Prospectus (as
      defined in the Placement Agency Agreement relating to the Offering to which
      the
      Company is a party) (the “Lock-up
      Period”);
      provided, that if (i) during the last 17 days of the Lock-up Period, the Company
      issues an earnings release or material news or a material event relating to
      the
      Company occurs or (ii) prior to the expiration of the Lock-up Period, the
      Company announces that it will release earnings results during the 16-day period
      beginning on the last day of the Lock-up Period, then in each case the Lock-up
      Period will be extended until the expiration of the 18-day period beginning
      on
      the date of the issuance of the earnings release or the occurrence of the
      material news or material event, as applicable, unless the Representative
      waives, in writing, such extension, except that such extension will not apply
      if, within three days prior to the expiration of the Lock-up Period, the Company
      delivers a certificate, signed by the Chief Financial Officer or Chief Executive
      Officer of the Company, certifying on behalf of the Company that the Company’s
      Shares are “actively traded securities” (as defined in Regulation M); provided,
      further, that the foregoing restrictions shall not apply to: 

     

    
      
        
        

      

      
        D-1

        
          

        

      

      
        
        

      

    

     

    (A)  the
      transfer of any or all of the Shares owned by the undersigned, either during
      the
      undersigned’s lifetime or upon death, by gift, will or intestate succession to
      the immediate family of the undersigned or to a trust the beneficiaries of
      which
      are exclusively the undersigned and/or a member or members of his immediate
      family; provided, however, that in any such case, it shall be a condition to
      such transfer that the transferee executes and delivers to the Representative
      an
      agreement stating that the transferee is receiving and holding the Shares
      subject to the provisions of this letter agreement, and there shall be no
      further transfer of such Shares, except in accordance with this letter
      agreement;

    

    (B)  the
      sale
      of up to an aggregate of 200,000 Shares by the officers and directors of the
      Company that have entered into agreements similar to this one on the date
      hereof; or

    

    (C)  the
      entering into, at any time after the closing of the Offering, a 10b5-1 plan
      if
      then permitted by the Company
      so long
      as there are no sales of Shares under such plan during the Lock-Up Period (as
      may be extended pursuant to the second paragraph hereof).

    

    The
      undersigned shall provide at least one business day’s advance written notice to
      the Company of any such proposed transaction in order to confirm compliance
      with
      the foregoing conditions and limitations. The undersigned hereby acknowledges
      and agrees that written notice of any extension of the Lock-up Period pursuant
      to the preceding sentence will be delivered by the Representative to the Company
      and that any such notice properly delivered will be deemed to have been given
      to, and received by, the undersigned. 

    

    The
      undersigned also agrees and consents to the entry of stop transfer instructions
      with the Company’s transfer agent and registrar against the transfer of Shares
      or securities convertible into or exchangeable or exercisable for Shares held
      by
      the undersigned during the Lock-up Period except in compliance with the
      foregoing restrictions.

    

    With
      respect to the Offering only, the undersigned waives any registration rights
      relating to registration under the Securities Act of any Shares owned either
      of
      record or beneficially by the undersigned, including any rights to receive
      notice of the Offering.

    

    This
      agreement is irrevocable and will be binding on the undersigned and the
      respective successors, heirs, personal representatives, and assigns of the
      undersigned.

     

    ____________________________

    Printed
      Name of Holder

    

    By:_________________________

    Signature

    

     

    ____________________________

    Printed
      Name of Person Signing

    

    (and
      indicate capacity of person signing if 

    signing
      as custodian, trustee, or on behalf 

    of
      an
      entity)

    

    
      
        
        

      

      
        D-2

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      E

     

    
 

    Chief
      Financial Officer’s Certificate

    Pursuant
      to Section 7(a) of the Placement Agency Agreement

    

    

    This
      Certificate is delivered to Jefferies & Company, Inc. (“Jefferies”), in its
      capacity as the Placement Agent named in the Placement Agency Agreement dated
      as
      of the date hereof (the “Placement Agency Agreement”), between Discovery
      Laboratories, Inc.,
      a
      Delaware corporation (the “Company”) and Jefferies. I, John G. Cooper, Chief
      Financial Officer of the Company, hereby deliver this certificate on behalf
      of
      the Company in connection with the offering of the Offered Shares (the
“Offering”). Capitalized terms used herein and not otherwise defined shall have
      the meanings ascribed to them in the Placement Agency Agreement.

    

    Based
      on
      an examination of the Company’s financial records and schedules undertaken by me
      or members of my staff who are responsible for the Company’s financial and
      accounting records, and on our review of the minutes of the Company’s Board of
      Directors and the Audit Committee, Compensation Committee and Nominating and
      Corporate Governance Committee of the Board of Directors, I hereby certify
      that
      I have reviewed the amounts identified and enumerated on the copies of certain
      pages of contained or incorporated by reference in the Registration Statement
      and the Time of Sale Prospectus attached hereto as Exhibit
      A
      and have
      verified that such amounts are true and correct. Each such amount has been
      derived from information maintained by the Company or otherwise available to
      it.

    

    The
      Placement Agent is entitled to rely upon this Certificate in conducting and
      documenting its investigations of the affairs of the Company in connection
      with
      the Offering.

    

    [remainder
      of page intentionally blank]

     

    
      
        
        

      

      
        E-1

        
          

        

      

      
        
        

      

    

     

    IN
      WITNESS WHEREOF, I have hereunto signed my name on this ____ day of December,
      2007.

     

     

    DISCOVERY
      LABORATORIES, INC.

     

     

    By:_______________________________

    Name:
      John G. Cooper

    Title:
      Chief Financial Officer

     

     

    

    [Signature
      Page to CFO’s Certificate]

    

    
      
        
        

      

      
        E-2

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      F

     

    
 

    DISCOVERY
      LABORATORIES, INC.

    

    

    Chief
      Financial Officer’s Certificate

    Pursuant
      to Section 7(g) of the Placement Agency Agreement

    

    

    This
      Certificate is delivered to Jefferies & Company, Inc. (“Jefferies”), in its
      capacity as the Placement Agent named in the Placement Agency Agreement dated
      as
      of December 7, 2007 (the “Placement Agency Agreement”), between Discovery
      Laboratories, Inc.,
      a
      Delaware corporation (the “Company”) and, Jefferies.
      I, John
      G. Cooper, Chief Financial Officer of the Company, hereby deliver this
      certificate on behalf of the Company in connection with the offering of the
      Offered Shares (the “Offering”). Capitalized terms used herein and not otherwise
      defined shall have the meanings ascribed to them in the Placement Agency
      Agreement.

    

    Reference
      is made to the certificate dated December 7, 2007 (the “December 7
      Certificate”) with respect to the procedures carried out by myself or members of
      my staff who are responsible for the Company’s financial and accounting records
      with respect to certain information contained or incorporated by reference
      in
      the Registration Statement and the Prospectus. I have reviewed the amounts
      identified and enumerated on the copies of certain pages of contained or
      incorporated by reference in the Registration Statement and the Prospectus
      attached hereto as Exhibit
      A
      and have
      verified that such amounts are true and correct. Each such amount has been
      derived from information maintained by the Company or otherwise available to
      it.

    

    I
      hereby
      reaffirm as of the date hereof, and as though made on the date hereof, all
      statements made in the December 7 Certificate.

    

    The
      Placement Agent is entitled to rely upon this Certificate in conducting and
      documenting its investigations of the affairs of the Company in connection
      with
      the Offering.

    

    
      
        
        

      

      
        F-1

        
          

        

      

      
        
        

      

    

     

    IN
      WITNESS WHEREOF, I have hereunto signed my name on this ___ day of December,
      2007.

     

     

    DISCOVERY
      LABORATORIES, INC.

     

    

    By:_______________________________

    Name:
      John G. Cooper

    Title:
      Chief Financial Officer

     

     

     

    [Signature
      Page to CFO’s Bring Down Certificate]

    

    
      
        
        

      

      
        F-2

        
          

        

      

      
        
        

      

    

     

    EXHIBIT
      G

     

     

    SUBSCRIPTION
      AGREEMENT

    

     

    Discovery
      Laboratories, Inc.

    2600
      Kelly Road, Suite 100

    Warrington,
      Pennsylvania 18976-3622

    

    Gentlemen:

    

    The
      undersigned (the “Investor”)
      hereby
      confirms its agreement with you as follows: 

     

    1.
      This
      Subscription Agreement (this “Agreement”)
      is
      made as of the date set forth below between Discovery
      Laboratories, Inc.,
      a
      Delaware corporation (the “Company”),
      and
      the Investor.

     

    2.
      The
      Company has authorized the sale and issuance to certain investors of up to
      an
      aggregate of 10,000,000 shares (each a “Share,”
and
      collectively the “Shares”)
      of its
      common stock, par value $.001 per share (the “Common
      Stock”),
      subject to adjustment by the Company’s Board of Directors, or a committee
      thereof, for a purchase price of $2.50 per Share (the “Purchase
      Price”).

     

    3.
      The
      offering and sale of the Shares (the “Offering”)
      are
      being made pursuant to (1) an effective Registration Statement on Form S-3
      (including the Prospectus contained therein (the “Base
      Prospectus”),
      the
“Registration
      Statement”)
      filed
      by the Company with the Securities and Exchange Commission (the “Commission”),
      (2)
      if applicable, certain “free writing prospectuses” (as that term is defined in
      Rule 405 under the Securities Act of 1933, as amended), that have or will be
      filed with the Commission and delivered to the Investor on or prior to the
      date
      hereof and (3) a Prospectus Supplement (the “Prospectus
      Supplement”
and
      together with the Base Prospectus, the “Prospectus”)
      containing certain supplemental information regarding the Shares and terms
      of
      the Offering that will be filed with the Commission and delivered to the
      Investor (or made available to the Investor by the filing by the Company of
      an
      electronic version thereof with the Commission) along with the Company’s
      counterpart to this Agreement.

     

    4.
      The
      Company and the Investor agree that the Investor will purchase from the Company
      and the Company will issue and sell to the Investor the Shares
      set
      forth
      below for the aggregate purchase price set forth below. The Shares shall be
      purchased pursuant to the Terms and Conditions for Purchase of Shares attached
      hereto as Annex
      I
      and
      incorporated herein by this reference as if fully set forth herein. The Investor
      acknowledges that the Offering is not being underwritten by the placement agent
      (the “Placement
      Agent”)
      named
      in the Prospectus Supplement and that there is no minimum offering
      amount.

     

    5.
      The
      manner of settlement of the Shares purchased by the Investor shall be determined
      by such Investor as follows (check
      one):

     

    
      	
              [____]

            	
              A.

            	
              Delivery
                by electronic book-entry at The Depository Trust Company (“DTC”),
                registered in the Investor’s name and address as set forth below, and
                released by Continental Stock Transfer & Trust Company, the Company’s
                transfer agent (the “Transfer
                Agent”),
                to the Investor at the Closing (as defined in Section 3.1 of Annex
                I
                hereto). NO
                LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION OF THIS AGREEMENT
                BY
                THE INVESTOR AND THE COMPANY, THE INVESTOR SHALL:
                

            

    

     

    
      
        
        

      

      
        G-1

        
          

        

      

      
        
        

      

    

     

    
      	 	 	
              (I)

            	
              DIRECT
                THE BROKER-DEALER AT WHICH THE ACCOUNT OR ACCOUNTS TO BE CREDITED
                WITH THE
                SHARES ARE MAINTAINED TO SET UP A DEPOSIT/WITHDRAWAL AT CUSTODIAN
                (“DWAC”)
                INSTRUCTING THE TRANSFER AGENT TO CREDIT SUCH ACCOUNT OR ACCOUNTS
                WITH THE
                SHARES, AND

            

    

     

    
      	 	
              (II)

            	
              REMIT
                BY WIRE TRANSFER THE AMOUNT OF FUNDS EQUAL TO THE AGGREGATE PURCHASE
                PRICE
                FOR THE SHARES BEING PURCHASED BY THE INVESTOR TO THE FOLLOWING
                ACCOUNT:

            

    

     

    Deutsche
      Bank Trust Company Americas

    ABA:
      021001033

    Account
      Name - Trust and Securities Services

    Account
      Number - 01419647

    F.C.T.
      -
      Discovery Labs/Jefferies and Co 62793

     

    -
      OR
      -

     

    
      	
              [____]

            	
              B.

            	
              Delivery
                versus payment (“DVP”)
                through DTC (i.e., the Company shall deliver Shares registered in
                the
                Investor’s name and address as set forth below and released by the
                Transfer Agent to the Investor through DTC at the Closing directly
                to the
                account(s) at Jefferies
                & Company, Inc.
                (“Jefferies”)
                identified by the Investor and simultaneously therewith payment shall
                be
                made by Jefferies
                by
                wire transfer to the Company). NO
                LATER THAN ONE (1) BUSINESS DAY AFTER THE EXECUTION OF THIS AGREEMENT
                BY
                THE INVESTOR AND THE COMPANY, THE INVESTOR SHALL:
                

            

    

     

    
      	 	
              (I)

            	
              NOTIFY
                JEFFERIES
                OF THE ACCOUNT OR ACCOUNTS AT JEFFERIES
                TO BE CREDITED WITH THE SHARES BEING PURCHASED BY SUCH INVESTOR,
                AND
                

            

    

     

    
      	 	 	
              (II)

            	
              CONFIRM
                THAT THE ACCOUNT OR ACCOUNTS AT JEFFERIES
                TO
                BE CREDITED WITH THE SHARES BEING PURCHASED BY THE INVESTOR HAVE
                A MINIMUM
                BALANCE EQUAL TO THE AGGREGATE PURCHASE PRICE FOR THE SHARES BEING
                PURCHASED BY THE INVESTOR.

            

    

     

    IT
      IS THE INVESTOR’S RESPONSIBILITY TO (A) MAKE THE NECESSARY WIRE TRANSFER OR
      CONFIRM THE PROPER ACCOUNT BALANCE IN A TIMELY MANNER AND (B) ARRANGE FOR
      SETTLEMENT BY WAY OF DWAC OR DVP IN A TIMELY MANNER. IF THE INVESTOR DOES NOT
      DELIVER THE AGGREGATE PURCHASE PRICE FOR THE SHARES OR DOES NOT MAKE PROPER
      ARRANGEMENTS FOR SETTLEMENT IN A TIMELY MANNER, THE SHARES MAY NOT BE DELIVERED
      AT CLOSING TO THE INVESTOR OR THE INVESTOR MAY BE EXCLUDED FROM THE CLOSING
      ALTOGETHER.

     

    
      
        
        

      

      
        G-2

        
          

        

      

      
        
        

      

    

     

    6. The
      Investor represents that, except as set forth below, (a) it has had no position,
      office or other material relationship within the past three years with the
      Company or persons known to it to be affiliates of the Company, (b) it is not
      a
      NASD member or an Associated Person (as such term is defined under the NASD
      Membership and Registration Rules Section 1011) as of the Closing, and (c)
      neither the Investor nor any group of Investors (as identified in a public
      filing made with the Commission) of which the Investor is a part in connection
      with the Offering of the Shares, acquired, or obtained the right to acquire,
      20%
      or more of the Common Stock (or securities convertible into or exercisable
      for
      Common Stock) or the voting power of the Company on a post-transaction basis.
      Exceptions:

     

    
      

    

    (If
      no
      exceptions, write “none.” If left blank, response will be deemed to be
“none.”)

     

    7. The
      Investor represents that it has received (or otherwise had made available to
      it
      by the filing by the Company of an electronic version thereof with the
      Commission) the Base Prospectus, dated October 11, 2005, which is a part of
      the
      Company’s Registration Statement, the documents incorporated by reference
      therein, and any free writing prospectus (collectively, the “Disclosure
      Package”),
      prior
      to or in connection with the receipt of this Agreement and the Prospectus
      Supplement (or the filing by the Company of an electronic version thereof with
      the Commission) along with the Company’s counterpart to this
      Agreement.

     

    8. No
      offer
      by the Investor to buy Shares will be accepted and no part of the Purchase
      Price
      will be delivered to the Company until the Company has accepted such offer
      by
      countersigning a copy of this Agreement, and any such offer may be withdrawn
      or
      revoked by the Investor, without obligation or commitment of any kind, at any
      time prior to the Company (or the Placement Agent on behalf of the Company)
      sending (orally, in writing, or by electronic mail) notice of its acceptance
      of
      such offer. An indication of interest will involve no obligation or commitment
      of any kind until this Agreement is accepted and countersigned by or on behalf
      of the Company.

     

    
      
        
        

      

      
        G-3

        
          

        

      

      
        
        

      

    

     

    Number
      of
      Share:_________________________________

     

    Purchase
      Price Per Share: $__________________________

     

    Aggregate
      Purchase Price: $_________________________

    

     

    Please
      confirm that the foregoing correctly sets forth the agreement between us by
      signing in the space provided below for that purpose.

    

     

    Dated
      as
      of: _____________ __, 2007

     

    

    __________________________

    INVESTOR

     

    By:___________________________

    Print
      Name:_____________________

    Title:__________________________

    Address:_______________________

    ______________________________

     

     

    

    

    Agreed
      and Accepted

    this
      ___
      day of _________________, 2007:

    

     

    DISCOVERY
      LABORATORIES, INC.

     

    

    By:___________________________

    Print
      Name

    Title:
      

     

    
      
        
        

      

      
        G-4

        
          

        

      

      
        
        

      

    

     

    ANNEX
      I

     

    TERMS
      AND CONDITIONS FOR PURCHASE OF SHARES

     

    1. Authorization
      and Sale of the Shares. Subject
      to the terms and conditions of this Agreement, the Company has authorized the
      sale of the Shares.

     

    2. Agreement
      to Sell and Purchase the Shares; Placement Agent.

     

    2.1 At
      the
      Closing, the Company will sell to the Investor, and the Investor will purchase
      from the Company, upon the terms and conditions set forth herein, the number
      of
      Shares set forth on the last page of the Agreement to which these Terms and
      Conditions for Purchase of Shares are attached as Annex
      I
      (the
“Signature
      Page”)
      for
      the aggregate purchase price therefor set forth on the Signature
      Page.

     

    2.2 The
      Company proposes to enter into substantially this same form of Subscription
      Agreement with certain other investors (the “Other
      Investors”)
      and
      expects to complete sales of Shares to them. The Investor and the Other
      Investors are hereinafter sometimes collectively referred to as the
“Investors,”
and
      this Agreement and the Subscription Agreements executed by the Other Investors
      are hereinafter sometimes collectively referred to as the “Agreements.” 

    

    2.3 Investor
      acknowledges that the Company has agreed to pay Jefferies
      & Company, Inc. (the
      “Placement
      Agent”)
      a fee
      (the “Placement
      Fee”)
      in
      respect of the sale of Shares to the Investor.

    

    2.4 The
      Company has entered into a Placement Agency Agreement, dated December 7, 2007
      (the “Placement
      Agreement”),
      with
      the Placement Agent that contains certain representations, warranties, covenants
      and agreements of the Company that may be relied upon by the Investor, which
      shall be a third party beneficiary thereof. 

    

    3. Closings
      and Delivery of the Shares and Funds. 

     

    3.1 Closing.
      The
      completion of the purchase and sale of the Shares (the “Closing”)
      shall
      occur at a place and time (the “Closing
      Date”)
      to be
      specified by the Company and the Placement Agent, and of which the Investors
      will be notified in advance by the Placement Agent, in accordance with Rule
      15c6-1 promulgated under the Securities Exchange Act of 1934, as amended (the
      “Exchange
      Act”).
      At
      the Closing, (a) the Company shall cause the Transfer Agent to deliver to the
      Investor the number of Shares set forth on the Signature Page registered in
      the
      name of the Investor or, if so indicated on the Investor Questionnaire attached
      hereto as Exhibit
      A,
      in the
      name of a nominee designated by the Investor and (b) the aggregate purchase
      price for the Shares being purchased by the Investor will be delivered by or
      on
      behalf of the Investor to the Company. 

     

    3.2 Conditions
      to the Company’s Obligations.
      (a)
      The
      Company’s obligation to issue and sell the Shares to the Investor shall be
      subject to: (i) the receipt by the Company of the purchase price for the Shares
      being purchased hereunder as set forth on the Signature Page and (ii) the
      accuracy of the representations and warranties made by the Investor and the
      fulfillment of those undertakings of the Investor to be fulfilled prior to
      the
      Closing Date.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    (b) Conditions
      to the Investor’s Obligations.
      The
      Investor’s obligation to purchase the Shares will be subject to the accuracy of
      the representations and warranties made by the Company and the fulfillment
      of
      those undertakings of the Company to be fulfilled prior to the Closing Date,
      including without limitation, those contained in the Placement Agreement, and
      to
      the condition that the Placement Agent shall not have: (a) terminated the
      Placement Agreement pursuant to the terms thereof or (b) determined that the
      conditions to the closing in the Placement Agreement have not been satisfied.
      The Investor’s obligations are expressly not conditioned on the purchase by any
      or all of the Other Investors of the Shares that they have agreed to purchase
      from the Company.

    

    3.3 Delivery
      of Funds. 

    

    (a) Delivery
      by Electronic Book-Entry at The Depository Trust Company.
      If the
      Investor elects to settle the Shares purchased by such Investor through delivery
      by electronic book-entry at DTC, no
      later than one (1) business day after the execution of this Agreement by the
      Investor and the Company,
      the
      Investor shall remit by wire transfer the amount of funds equal to the aggregate
      purchase price for the Shares being purchased by the Investor to the following
      account designated by the Company and the Placement Agent pursuant to the terms
      of that certain Escrow Agreement (the “Escrow
      Agreement”)
      dated
      as of December 7, 2007, by and among the Company, the Placement Agent and
      Deutsche Bank Trust Company Americas (the “Escrow
      Agent”):

    

    Deutsche
      Bank Trust Company Americas

    ABA:
      021001033

    Account
      Name - Trust and Securities Services

    Account
      Number - 01419647

    F.C.T.
      -
      Discovery Labs/Jefferies and Co 62793

     

    Such
      funds shall be held in escrow until the Closing and delivered by the Escrow
      Agent on behalf of the Investors to the Company upon the satisfaction, in the
      sole judgment of Jefferies, of the conditions set forth in Section
      3.2(b)
      hereof.
      The Placement Agent shall have no rights in or to any of the escrowed funds,
      unless the Placement Agent and the Escrow Agent are notified in writing by
      the
      Company in connection with the Closing that a portion of the escrowed funds
      shall be applied to the Placement Fee. The
      Company agrees to indemnify and hold the Escrow Agent harmless from and against
      any and all losses, costs, damages, expenses and claims (including, without
      limitation, court costs and reasonable attorneys fees) (“Losses”)
      arising under this Section
      3.3
      or
      otherwise with respect to the funds held in escrow pursuant hereto or arising
      under the Escrow Agreement, unless it is finally determined that such Losses
      resulted directly from the willful misconduct or gross negligence of the Escrow
      Agent. Anything in this Agreement to the contrary notwithstanding, in no event
      shall the Escrow Agent be liable for any special, indirect or consequential
      loss
      or damage of any kind whatsoever (including but not limited to lost profits),
      even if the Escrow Agent has been advised of the likelihood of such loss or
      damage and regardless of the form of action.

    

    Investor
      shall also furnish to Jefferies a completed W-9 form (or, in the case of an
      Investor who is not a United States citizen or resident, a W-8
      form).

    

    (b) Delivery
      Versus Payment through The Depository Trust Company.
      If the
      Investor elects to settle the Shares purchased by such Investor by delivery
      versus payment through DTC, no
      later than one (1) business day after the execution of this Agreement by the
      Investor and the Company,
      the
      Investor shall confirm that the account or accounts at Jefferies
      to be
      credited with the Shares being purchased by the Investor have a minimum balance
      equal to the aggregate purchase price for the Shares being purchased by the
      Investor. 

     

    
      
        
        

      

      
        -
          A - 2
          -

        
          

        

      

      
        
        

      

    

     

    3.4 Delivery
      of Shares. 

    

    (a) Delivery
      by Electronic Book-Entry at The Depository Trust Company.
      If the
      Investor elects to settle the Shares purchased by such Investor through delivery
      by electronic book-entry at DTC, no
      later than one (1) business day after the execution of this Agreement by the
      Investor and the Company,
      the
      Investor shall direct the broker-dealer at which the account or accounts to
      be
      credited with the Shares being purchased by such Investor are maintained, which
      broker/dealer shall be a DTC participant, to set up a Deposit/Withdrawal at
      Custodian (“DWAC”)
      instructing Continental Stock Transfer & Trust Company, the Company’s
      transfer agent, to credit such account or accounts with the Shares by means
      of
      an electronic book-entry delivery. Such DWAC shall indicate the settlement
      date
      for the deposit of the Shares, which date shall be provided to the Investor
      by
      Jefferies. Simultaneously with the delivery to the Company by the Escrow Agent
      of the funds held in escrow pursuant to Section
      3.3
      above,
      the Company shall direct its transfer agent to credit the Investor’s account or
      accounts with the Shares pursuant to the information contained in the DWAC.
      

    

    (b) Delivery
      Versus Payment through The Depository Trust Company.
      If the
      Investor elects to settle the Shares purchased by such Investor by delivery
      versus payment through DTC, no
      later than one (1) business day after the execution of this Agreement by the
      Investor and the Company,
      the
      Investor shall notify Jefferies
      of the
      account or accounts at Jefferies to be credited with the Shares being purchased
      by such Investor. On the Closing Date, the Company shall deliver the Shares
      to
      the Investor through DTC directly to the account or accounts at Jefferies
      identified by Investor and simultaneously therewith payment shall be made by
      Jefferies by wire transfer to the Company. 

    

    4. Representations,
      Warranties and Covenants of the Investor.

     

    The
      Investor represents and warrants to, and agrees with, the Company and the
      Placement Agent that:

     

    
      
        
        

      

      
        -
          A - 3
          -

        
          

        

      

      
        
        

      

    

     

    4.1 The
      Investor (a) is knowledgeable, sophisticated and experienced in making, and
      is
      qualified to make decisions with respect to, investments in shares presenting
      an
      investment decision like that involved in the purchase of the Shares, including
      investments in securities issued by the Company and investments in comparable
      companies, (b) has answered all questions on the Signature Page and the Investor
      Questionnaire for use in preparation of the Prospectus Supplement and the
      answers thereto are true and correct as of the date hereof and will be true
      and
      correct as of the Closing Date and (c) in connection with its decision to
      purchase the number of Shares set forth on the Signature Page, has received
      and
      is relying solely upon the Disclosure Package and the documents incorporated
      by
      reference therein.

     

    4.2 The
      Investor acknowledges that (a) no action has been or will be taken in any
      jurisdiction outside the United States by the Company or the Placement Agent
      that would permit an offering of the Shares, or possession or distribution
      of
      offering materials in connection with the issue of the Shares in any
      jurisdiction outside the United States where action for that purpose is
      required, (b) if the Investor is outside the United States, it will comply
      with
      all applicable laws and regulations in each foreign jurisdiction in which it
      purchases, offers, sells or delivers Shares or has in its possession or
      distributes any offering material, in all cases at its own expense and (c)
      the
      Placement Agent is not authorized to make and has not made any representation,
      disclosure or use of any information in connection with the issue, placement,
      purchase and sale of the Shares, except as set forth or incorporated by
      reference in the Base Prospectus or the Prospectus Supplement.

     

    4.3 The
      Investor acknowledges that (a)
      the
      Investor has full right, power, authority and capacity to enter into this
      Agreement and to consummate the transactions contemplated hereby and has taken
      all necessary action to authorize the execution, delivery and performance of
      this Agreement, and (b) this Agreement constitutes a valid and binding
      obligation of the Investor enforceable against the Investor in accordance with
      its terms, except as enforceability may be limited by applicable bankruptcy,
      insolvency, reorganization, moratorium or similar laws affecting creditors’ and
      contracting parties’ rights generally and except as enforceability may be
      subject to general principles of equity (regardless of whether such
      enforceability is considered in a proceeding in equity or at law) and except
      as
      to the enforceability of any rights to indemnification or contribution that
      may
      be violative of the public policy underlying any law, rule or regulation
      (including any federal or state securities law, rule or
      regulation).

     

    4.4 The
      Investor understands that nothing in this Agreement, the Prospectus or any
      other
      materials presented to the Investor in connection with the purchase and sale
      of
      the Shares constitutes legal, tax or investment advice. The Investor has
      consulted such legal, tax and investment advisors as it, in its sole discretion,
      has deemed necessary or appropriate in connection with its purchase of
      Shares.

     

    4.5 Since
      the
      date on which the Placement Agent first contacted such Investor about the
      Offering, the Investor has not engaged in any transactions in the securities
      of
      the Company (including, without limitation, any Short Sales (as defined below)
      involving the Company’s securities). Each Investor covenants that it will not
      engage in any transactions in the securities of the Company (including Short
      Sales) prior to the time that the transactions contemplated by this Agreement
      are publicly disclosed. Each Investor agrees that it will not use any of the
      Shares acquired pursuant to this Agreement to cover any short position in the
      Common Stock if doing so would be in violation of applicable securities laws.
      For purposes hereof, “Short Sales” include, without limitation, all “short
      sales” as defined in Rule 200 promulgated under Regulation SHO under the
      Exchange Act, whether or not against the box, and all types of direct and
      indirect stock pledges, forward sales contracts, options, puts, calls, short
      sales, swaps, “put equivalent positions” (as defined in Rule 16a-1(h) under the
      Exchange Act) and similar arrangements (including on a total return basis),
      and
      sales and other transactions through non-US broker dealers or foreign regulated
      brokers.

     

    
      
        
        

      

      
        -
          A - 4
          -

        
          

        

      

      
        
        

      

    

     

    5. Survival
      of Representations, Warranties and Agreements; Third Party Beneficiary.
Notwithstanding
      any investigation made by any party to this Agreement or by the Placement Agent,
      all covenants, agreements, representations and warranties made by the Company
      and the Investor herein will survive the execution of this Agreement, the
      delivery to the Investor of the Shares being purchased and the payment therefor.
      The Placement Agent shall be a third party beneficiary with respect to the
      representations, warranties and agreements of the Investor in Section
      4
      hereof.

     

    6. Notices.
      All
      notices, requests, consents and other communications hereunder will be in
      writing, will be mailed (a) if within the domestic United States by first-class
      registered or certified airmail, or nationally recognized overnight express
      courier, postage prepaid, or by facsimile or (b) if delivered from outside
      the
      United States, by International Federal Express or facsimile, and will be deemed
      given (i) if delivered by first-class registered or certified mail domestic,
      three business days after so mailed, (ii) if delivered by nationally recognized
      overnight carrier, one business day after so mailed, (iii) if delivered by
      International Federal Express, two business days after so mailed and (iv) if
      delivered by facsimile, upon electric confirmation of receipt and will be
      delivered and addressed as follows:

     

    
      	(a)  	
              if
                to the Company, to:

               

              
                Discovery
                  Laboratories, Inc.

                2600
                  Kelly Road, Suite 100

                Warrington,
                  Pennsylvania 18976-3622 

                Attention:
                  David Lopez, Esq. 

                Facsimile:
                  (215) 488-9557

                

                 

                with
                  copies to:
                  

                 

                Goodwin
                  Procter, LLP

                53
                  State Street

                Boston,
                  MA 02109

                Attention:
                  Mitchell S. Bloom, Esq.

                Facsimile:
                  (617) 523-1231

              

            

    

     

    (b)
      if
      to the
      Investor, at its address on the Signature Page hereto, or at such other address
      or addresses as may have been furnished to the Company in writing.

     

    7. Changes.
      This
      Agreement may not be modified or amended except pursuant to an instrument in
      writing signed by the Company and the Investor.

     

    8. Headings.
      The
      headings of the various sections of this Agreement have been inserted for
      convenience of reference only and will not be deemed to be part of this
      Agreement.

     

    
      
        
        

      

      
        -
          A - 5
          -

        
          

        

      

      
        
        

      

    

     

    9. Severability.
      In
      case
      any provision contained in this Agreement should be invalid, illegal or
      unenforceable in any respect, the validity, legality and enforceability of
      the
      remaining provisions contained herein will not in any way be affected or
      impaired thereby.

     

    10. Governing
      Law. This
      Agreement will be governed by, and construed in accordance with, the internal
      laws of the State of New York, without giving effect to the principles of
      conflicts of law that would require the application of the laws of any other
      jurisdiction.

     

    11. Counterparts.
      This
      Agreement may be executed in two or more counterparts, each of which will
      constitute an original, but all of which, when taken together, will constitute
      but one instrument, and will become effective when one or more counterparts
      have
      been signed by each party hereto and delivered to the other parties. The Company
      and the Investor acknowledge and agree that the Company shall deliver its
      counterpart to the Investor along with the Prospectus Supplement (or the filing
      by the Company of an electronic version thereof with the Commission).

     

    12. Confirmation
      of Sale.
      The
      Investor acknowledges and agrees that such Investor’s receipt of the Company’s
      counterpart to this Agreement, together with the Prospectus Supplement (or
      the
      filing by the Company of an electronic version thereof with the Commission),
      shall constitute written confirmation of the Company’s sale of Shares to such
      Investor.

     

    13. Press
      Release.
      The
      Company and the Investor agree that the Company shall issue a press release
      disclosing the material terms of the Offering prior to the opening of the
      financial markets in New York City on the business day immediately after the
      date hereof.

     

    14. Termination.
      In the
      event that the Placement Agreement is terminated by the Placement Agent pursuant
      to the terms thereof, this Agreement shall terminate without any further action
      on the part of the parties hereto.

     

    
      
        
        

      

      
        -
          A - 6
          -

        
          

        

      

      
        
        

      

    

     

    Exhibit
      A

     

    DISCOVERY
      LABORATORIES,
      INC.

     

    INVESTOR
      QUESTIONNAIRE

     

    Pursuant
      to Section
      3
      of
Annex
      I
      to the
      Agreement, please provide us with the following information:

    
 

    
      	
              1. The
                exact name that your Shares are to be registered in. You may use
                a nominee
                name if appropriate:

            	 	 
	 	 	 
	
              2. The
                relationship between the Investor and the registered holder listed
                in
                response to item 1 above:

            	 	 
	 	 	 
	
              3. The
                mailing address of the registered holder listed in response to item
                1
                above:

            	 	 
	 	 	 
	
              4. The
                Social Security Number or Tax Identification Number of the registered
                holder listed in the response to item 1 above:

            	 	 
	 	 	 
	
              5. Name
                of DTC Participant (broker-dealer at which the account or accounts
                to be
                credited with the Shares are maintained):

            	 	 
	 	 	 
	
              6. DTC
                Participant Number:

            	 	 
	 	 	 
	
              7. Name
                of Account at DTC Participant being credited with the
                Shares:

            	 	 
	 	 	 
	
              8. Account
                Number at DTC Participant being credited with the Shares:Exhibit
      10.1:

    

    CONFIDENTIAL
      TREATMENT HAS BEEN REQUESTED FOR PORTIONS OF THIS DOCUMENT. THE REDACTED
      MATERIAL IS INDICATED IN THIS DOCUMENT WITH BRACKETED DOUBLE ASTERISKS ([**])
      AND
      HAS
      BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT
      TO A
      REQUEST FOR CONFIDENTIAL TREATMENT.

    

    SECOND
      AMENDMENT TO MOA 1450

    

    PROJECT
      SNOWDROP EQUIPMENT AMORTIZATION AGREEMENT

    

    BETWEEN
      A
& M PRODUCTS MANUFACTURING COMPANY, 1221 Broadway, Oakland, California
      94612, hereinafter “BUYER”
and
      Oil-Dri Corporation of America, 410 N. Michigan Avenue, Chicago, Illinois,
      60611, hereinafter “SELLER.” 

    

    WHEREAS,
      Seller will be purchasing certain machinery and equipment (“Equipment”
unless
      specified otherwise) on behalf of the Buyer as described in Section A below
      in
      order to implement Project Snow Drop for Buyer’s Fresh Step coarse product;
      and

    

    WHEREAS,
      Seller is producing Products, as that term is defined in the Memorandum of
      Agreement No. 1450 between Buyer and Seller dated March 12, 2001 and as amended
      by the First Amendment to Memorandum of Agreement No. 1450 dated December 13,
      2002 (as so amended, the “MOA
      Agreement”),
      for
      the Buyer at Seller’s plant in Ochlocknee, Georgia (the “Plant”)
      pursuant to the MOA Agreement, and whereas, it is in the parties’ mutual best
      interests to utilize the Equipment in the production of said Product for the
      Buyer; the parties hereby agree as follows:

    

    General
      Description of the Equipment.
      The
      List of Equipment associated with this agreement are listed in the attached
      Equipment List (hereinafter “Attachment
      I”).
      The
      List of Equipment is comprised of two types of equipment hereby referred to
      as
“Class A” and “Class B.” Class A equipment consist of equipment either 1) needed
      for the project and replacing or upgrading the Seller’s existing plant
      capability or 2) needed for the project and part of the Seller’s plant
      infrastructure, or 3) Seller’s previously owned equipment. Class B is equipment
      needed specifically for the project that does not fit into Class A. Attachment
      I
      may be adjusted from time to time by Buyer and Seller during the course of
      construction and in any event will be finalized no later than the start of
      commercial production.

     

    
      	
              A.

            	
              Installation
                and Removal of Equipment.
                

            

    

     

    
      	 	
              (1)

            	
              Seller
                will install and procure the Equipment under Buyer’s
                supervision.

            

    

     

    
      	 	
              (2)

            	
              Buyer
                may remove any portion or all of the Equipment identified as Class
                B on
                Attachment I on demand at its cost; provided, however, that Buyer
                will
                take reasonable steps to avoid disruption of Seller’s normal production of
                the Product and provided that Buyer will repair any damage directly
                caused
                by removal of the Equipment. Upon termination for any reason of the
                MOA
                Agreement, Buyer will remove all Class B Equipment from the Plant
                at
                Buyer’s expense within thirty (30) days of the date of termination. Any
                Equipment remaining at the Plant after the expiration of said period
                will
                be deemed abandoned by Buyer (hereinafter “Abandonment”)
                unless an agreement to the contrary is reached between the
                parties.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	 	
              (3)

            	
              In
                the event of Abandonment of any portion or all of the Equipment,
                Seller,
                at its sole option, may remove the abandoned Equipment at Seller’s sole
                expense and dispose of the abandoned Equipment in any way Seller
                sees fit,
                or retain the abandoned Equipment. If Seller retains the abandoned
                Equipment, Seller will have free and unencumbered title to the abandoned
                Equipment. Buyer will not be liable for any damage caused by Seller’s
                removal of the abandoned Equipment.

            

    

     

    
      	B.	
              No
                Liens.
                Seller represents and warrants that it is the sole beneficial owner
                of the
                Plant and will retain the Class B Equipment there at all times. Seller
                also represents and warrants that it will keep the Class B Equipment
                free
                of any liens and/or encumbrances arising out of any work performed,
                materials furnished, or obligations incurred by Seller and will remove
                any
                such liens within thirty (30) days after they are
                filed.

            

    

     

    
      	C.	
              Maintenance
                of Equipment.
                Buyer and Seller will agree to the attached maintenance schedule
                and
                obligations (“Attachment
                II”)
                no later than the start up production on the Equipment. Attachment
                II may
                be amended by agreement between Buyer and Sell from time to time
                in
                writing. Notwithstanding the commitments in the schedule, Seller
                will
                perform all maintenance and repairs on all Equipment. With respect
                to
                Class B Equipment, Buyer shall be responsible for all costs. Seller
                shall
                invoice Buyer monthly for such costs. For any major repairs (over
                $[**]),
                Seller shall make reasonable efforts to obtain Buyer’s written prior
                approval for such expenses, provided that obtaining such approval
                will not
                impact Seller’s operations. Buyer will not be responsible for major
                repairs caused by Seller’s negligence or misuse, including Seller’s
                failure to perform routine maintenance, which shall remain the liability
                of Seller. Seller will maintain records of routine maintenance for
                the
                Equipment. With respect to Class A Equipment, Seller shall assume
                all
                costs of repair and maintenance.

            

    

     

    
      	D.	
              Insurance.
                Seller will, at its cost, maintain fire, lightning, tornado and extended
                coverage insurance with limits of at least [**] ($[**]) on the Equipment
                while at the Plant. Such insurance will provide protection from,
                among
                other things, fire and the usual perils covered by all risk insurance
                coverage, including sprinkler leakage. The insurance will name Buyer
                as an
                additional insured.

            

    

     

    
      	E.	
              Use
                of Equipment.
                With respect to Class B Equipment and except where Buyer will have
                otherwise agreed in writing, Seller will not:

            

    

     

    
      	 	
              (1)

            	
              Remove
                the Equipment from the Plant;

            

    

     

    
      	 	
              (2)

            	
              Lease,
                assign, mortgage, encumber or otherwise dispose of the
                Equipment;

            

    

     

    
      	 	
              (3)

            	
              Remove,
                alter or deface the Equipment number or inscription or permit the
                same;

            

    

     

    
      	 	
              (4)

            	
              Add
                to, subtract from, change or alter any mechanism on the Equipment
                or
                permit the same, except

            

    

     

    
      	 	
              a.

            	
              Add
                safety or environmental compliance devices if removable without injury
                to
                the Equipment and which do not interfere with the operation of its
                mechanism; or

            

    

     

    
      	
            	b.	
              Replace
                or repair parts and perform maintenance as required by this Equipment
                Amortization Agreement.

            

    

     

    
      	
            	c.	
              As
                required by a governmental body or regulatory
                action.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	 	
              (5)

            	
              Use
                the Equipment to produce anything for any third party or for Seller’s own
                use, except for production of Product for Buyer.
                

            

    

     

    With
      respect to Class A Equipment, Seller will not have any of the restrictions
      above, however, Seller shall be responsible for maintaining the equipment (or
      replacement equipment) in such a way as to not impact Seller’s production of
      Buyer’s Product requirements.

     

    
      	
              F.

            	
              Inspection.
                Upon reasonable notice, Buyer’s authorized representatives and employees
                will be permitted access to Seller’s plants and facilities during
                reasonable business hours during the Term to inspect the Equipment
                and to
                take a physical inventory of such Equipment. Seller’s records relating to
                routine maintenance for the Equipment will be available to Buyer
                for
                inspection upon request.

            

    

     

    
      	G.	
              Title.
                

            

    

     

    
      	 	
              (1)

            	
              Title
                to the Equipment will remain with Seller. All tools, special dies,
                molds,
                patterns, jigs, specifications, drawings, instructions and other
                property
                furnished to Seller by Buyer, or specifically paid for by Buyer,
                for use
                with the Equipment to make the Product, will be and remain the property
                of
                Buyer, will be subject to removal at any time, upon Buyer’s demand and
                will be used only in filling orders from Buyer or its nominee. Seller
                assumes all liability for loss or damage of such property.  

            

    

     

    
      	 	
              (2)

            	
              With
                respect to any Equipment, any modifications that Seller, including
                its
                officers or employees, conceive, make or develop and implement and/or
                execute in the course of this Equipment Amortization Agreement relating
                to
                the Equipment which might impact the production of Buyer’s Product will be
                the sole and exclusive property of Seller, and Seller will promptly
                disclose all such modifications to Buyer.

            

    

     

    
      	 	
              (3)

            	
              At
                Buyer’s request, title and ownership of some or all Class B Equipment,
                including any modifications as addressed in Section H (2), will be
                transferred to Buyer for a payment of $100, provided that such equipment
                is no longer needed for production of Buyer’s product requirements. Should
                title pass from Seller to Buyer, Buyer will remove such equipment
                from
                Seller’s facilities in accordance with Section A (2)
                above.

            

    

     

    
      	H.	
              Indemnity.
                While the Equipment is located at Seller’s Plant, Seller will indemnify,
                defend, and hold harmless the Buyer, and any corporation controlling,
                controlled by or under common control with Buyer, of, from and against
                any
                loss, damages, claims, liabilities, costs and expenses, including
                without
                limitation attorneys’ fees (collectively, “Claims”),
                arising out of or resulting from use of the Equipment or from any
                act or
                omission by Seller, its agents or subcontractors, attributable to
                bodily
                injury to, or death of, any person or damage to or destruction of
                any
                property, whether belonging to Buyer or to another, excepting only
                damages
                to the extent caused solely (except where prohibited by local law)
                by
                Buyer’s negligence. This section will survive the termination of the MOA
                Agreement and/or this Equipment Amortization
                Agreement

            

    

     

    
      	I.	
              Entire
                Agreement, Modifications.
                This Equipment Amortization Agreement supplements and amends the
                MOA
                Agreement, which remains in full force and effect; and except as
                supplemented and amended by the express written terms of this Equipment
                Amortization Agreement, the MOA Agreement remains unchanged. This
                Equipment Amortization Agreement (together with the MOA Agreement)
                constitutes the entire understanding between the parties as to the
                Equipment. This Equipment Amortization Agreement may be modified
                only by
                an agreement in writing.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    
      	J.	
              Taxes.
                With respect to Class B Equipment, Buyer will reimburse Seller for
                all
                sales, use and similar taxes that may be assessed against the Equipment
                while located at the Plant, except for taxes based on Seller’s net income
                and real property taxes. Seller agrees to file all appropriate property
                taxes.

            

    

     

    
      	K.	
              Amortization.
                

            

    

     

    
      	 	
              (1)

            	
              Buyer
                will reimburse Seller for the purchase cost of the Equipment in 36
                monthly
                payments. The estimated cost of the Equipment is $[**]; however,
                Buyer and
                Seller will agree on the actual cost of the Equipment no later than
                120
                days after the start of commercial production.

            

    

     

    
      	 	
              (2)

            	
              Buyer’s
                payments to Seller will include a [**]% Equipment Purchase and Handling
                Charge, and a [**]% Financing Charge. Seller agrees to rebate the
                Finance
                Charges to Buyer based upon an annual reconciliation of the tonnage
                volume
                increase versus Calendar Year 2007 Fresh Step Regular volume. Attachment
                III details an example of the Amortization of Capital, Purchase and
                Handling, Financing and Rebate calculation. Buyer’s obligation to pay
                Seller Equipment Purchase and Handling Charge and Financing will
                terminate
                after the final Equipment payment is made for month 36.
                

            

    

     

    
      	 	
              (3)

            	
              Seller
                will begin billing Buyer for the Capital, Purchase and Handling Charge
                and
                Financing Charge monthly commencing at month end following the start
                of
                commercial production. The charges will be based on the estimated
                equipment cost as listed above. Upon agreement of the actual equipment
                cost, Seller will correct the Buyers charges at the following month
                end.

            

    

     

    
      	 	
              (4)

            	
              The
                Seller will rebate Buyer a maximum of 100% of the Financing Charges
                for
                the prior twelve (12) month period provided that Buyer’s volume increases
                by [**] percent ([**]%) or more over the base volume. The Seller
                will
                rebate Buyer on a pro rata basis for volume increases of less than
                twelve
                percent over the base volume for the prior twelve (12) month period.
                Buyer
                and Seller agree that the base volume, for which increases will be
                measured, will be based on shipments from Seller’s Ochlocknee, GA facility
                and will be agreed upon no later than January 31,
                2008.

            

    

     

    
      	 	
              (5)

            	
              Seller
                will present the volume rebate calculation to Buyer no later than
                30 days
                following the twelfth (12), twenty-forth (24) and thirty-sixth (36)
                full
                month of commercial production and will issue a check for any rebate
                due
                to Buyer no later than 60 days after the twelfth (12), twenty-forth
                (24)
                and thirty-sixth (36) full month of commercial production. Seller’s
                obligation to pay volume rebate will terminate after the final rebate
                calculation is made and any applicable check issued after month
                36.

            

    

     

    
      	 	
              (6)

            	
              In
                the event that the MOA Agreement is terminated, Buyer will pay Seller
                the
                remaining unamortized equipment cost amount within in 90 days of
                the
                termination effective date.

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    IN
      WITNESS WHEREOF, Buyer and Seller have executed this Equipment Amortization
      Agreement as of the date first written above.

     

    
      	BUYER:	 	 	SELLER:
	A & M PRODUCTS MANUFACTURING
              COMPANY,	 	 	
              Oil-Dri Corporation of America, 

            
	a Delaware corporation	 	 	a Delaware corporation
	 	 	 	 
	 	 	 	 
	By:
               /s/ David Matthews	 	 	By:
              /s/ Jeffrey M. Libert
	
              
                

              

              Name: David
                Matthews

              Title: Director
                Contract manufacturing

            	 	 	
              
                

              

              Name: Jeffrey
                M. Libert

              Title: VP,
                Finance

            

    

     

    Attachment
      I - Equipment List

    Attachment
      II - Equipment Maintenance Schedule

    Attachment
      III - Capital Amortization, Purchase and Handling Charge and Volume Rebate
      Example

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    Attachment
      I - Second Amendment to MOA 1450 

    Equipment
      List

    

    

    Class
      A

    

    
      	 	
              1.

            	
              Utility
                Modifications 

            

    

    
      	 	 	 

      	 	
              A.

            	
              Plant
                Water - any piping modifications or connections made to the plant
                water
                supply. This includes the proposed water storage tank.
                

            

    

    
      	 	 	 

      	 	
              B.

            	
              Plant
                Compressed Air - any piping or modifications made to the plant compressed
                air system.

            

    

    
      	 	 	 

      	 	
              C.

            	
              Plant
                Electrical Power - any power or circuit breaker panels which are
                connected
                to the plant power system

            

      	 	 	 

    

    
      	 	
              D.

            	
              Waste
                disposal - any piping, valves or pumps which empty into the waste
                water
                holding tank.

            

    

    

    
      	 	
              2.

            	
              The
                [**].

            

    

    

    
      	 	
              3.

            	
              Relocation
                or modifications [**].

            

    

    

    
      	 	
              4.

            	
              The
                replacement [**].

            

    

    

    
      	 	
              5.

            	
              Building
                modifications.

            

    

    

    Class
      B

    

    [**]

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    Attachment
      II - Second Amendment to MOA 1450 

    Equipment
      Maintenance Agreement

     

    To
      be
      agreed upon no later than the start of commercial production per Section C
      of
      this agreement

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    Attachment
      III - Second Amendment to MOA 1450

     

    Capital
      Amortization, Purchase and Handling Charge and Volume Rebate Example
      Only

    

    
      	
              Capital
                Cost

            	
              $[**]

            	 	
              Estimated
                Base (Actual volume TBD)

            	
              [**]

            	 	 
	
              Admin
                Fee Percent

            	
              [**]%

            	 	
              Estimated
                Guaranteed Volume

            	
              [**]

            	 	 
	 	 	 	 	
              Assumed

            	 	 	 
	
              Cost
                of Capital

            	
              [**]%

            	 	 	
              Volumes

            	
              Incremental

            	
              Guaranteed

            	
              %
                Achieved

            
	 	 	 	
              Year
                1

            	
              [**]

            	
              [**]

            	
              [**]

            	
              [**]%

            
	 	 	 	
              Year
                2

            	
              [**]

            	
              [**]

            	
              [**]

            	
              [**]%

            
	 	 	 	
              Year
                3

            	
              [**]

            	
              [**]

            	
              [**]

            	
              [**]%

            

    

     

    
      
        	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                Volume
                  Rebate of
                  Interest 

              
	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	 	 	
                 Clx
                  Pays OD-

              	 	
                 

              
	
                 

              	
                 

              	
                Capital

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                Capital

              	
                 

              	
                Cumulative

              	
                 

              	 	 	
                 Capital,
                  Admin

              	 	
                  OD
                  Pays

              
	
                Month

              	
                 

              	
                 Balance

              	
                 

              	
                Admin
                  Fee

              	
                 

              	
                Interest

              	
                 

              	
                 Reimb

              	
                 

              	
                Interest

              	
                 

              	
                Year

              	
                 

              	
                 &
                  Interest

              	
                 

              	
                  Clorox

              
	
                0

              	
                 

              	
                $[**]

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	
                 

              	 	 	
                 

              	 	
                 

              
	
                1

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                2

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                3

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                4

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                O

              	 	
                $[**]

              	 	
                 

              
	
                5

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                n

              	 	
                $[**]

              	 	
                 

              
	
                6

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                e

              	 	
                $[**]

              	 	
                 

              
	
                7

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                8

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                9

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                10

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                11

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                12

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                $[**]

              
	
                13

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                14

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                15

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	 	 	
                $[**]

              	 	
                 

              
	
                16

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
                $[**]

              	
                 

              	
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Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00133-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00133-of-00352.parquet"}]]