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Exhibit 10.9    
    

THESE
SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED, OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF
AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNSEL) REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE
SECURITIES ACT OF 1933 ACT AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS. 

WARRANT AGREEMENT  

To
Purchase Shares of the Series C Preferred Stock of 

Sirtris
Pharmaceuticals, Inc. 

Dated
as of April 18, 2006 (the "Effective Date") 

        WHEREAS,
Sirtris Pharmaceuticals, Inc., a Delaware corporation (the "Company"), has entered into a Loan and Security Agreement of
even date herewith (the "Loan Agreement") with Hercules Technology Growth Capital, Inc., a Maryland corporation (the
"Warrantholder"); 

        WHEREAS,
the Company desires to grant to Warrantholder, in consideration for, among other things, the financial accommodations provided for in the Loan Agreement, the right to purchase
shares of its Series C Preferred Stock pursuant to this Warrant Agreement (the "Agreement"); 

        NOW,
THEREFORE, the Company and Warrantholder agree as follows: 

1.     GRANT OF THE RIGHT TO PURCHASE PREFERRED STOCK.  

        For value received, the Company hereby grants to the Warrantholder, and the Warrantholder is entitled, upon the terms and subject to the conditions hereinafter
set forth, to subscribe for and purchase, from the Company, a number of shares of fully paid and non-assessable shares of the Preferred Stock (as defined below) equal to the quotient
derived by dividing (a) $750,000 (5% of the sum of Tranche A and Tranche B as defined in the Loan Agreement) by (b) the Exercise Price (the "Warrant
Shares"). If the Company does not receive the Advance under Tranche B under the Loan Agreement, then the number of shares the Warrantholder is entitled to purchase hereunder
shall be equal to the quotient derived by dividing (a) $500,000 (5% of Tranche A) by (b) the Exercise Price. The Exercise Price is $1.12 per share (the
"Exercise Price"). The number and Exercise Price of such shares are subject to adjustment as provided in Section 8. As used herein, the following
terms shall have the following meanings: 

        "Act" means the Securities Exchange Act of 1933, as amended. 

        "Charter" means the Company's Certificate of Incorporation, as may be amended from time to time. 

        "Common Stock" means the Company's common stock; 

        "Initial Public Offering" means the initial underwritten public offering of the Company's Common Stock pursuant to a registration
statement under the Act, which public offering has been declared effective by the Securities and Exchange Commission ("SEC"); 

        "Merger Event" means a merger or consolidation involving the Company in which the Company is not the surviving entity, or in which the
outstanding shares of the Company's capital stock are otherwise converted into or exchanged for shares of capital stock of another entity. 

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        "Preferred Stock" means the Series C Preferred Stock of the Company and any other stock into or for which the Series C
Preferred Stock may be converted or exchanged, and upon and after the occurrence of an event which results in the automatic or voluntary conversion, redemption or retirement of all (but not less than
all) of the outstanding shares of such Preferred Stock, including, without limitation, the consummation of an Initial Public Offering of the Common Stock in which such a conversion occurs, then from
and after the date upon which such outstanding shares are so converted, redeemed or retired, "Preferred Stock" shall mean such Common Stock; and 

        "Purchase Price" means, with respect to any exercise of this Warrant, an amount equal to the Exercise Price as of the relevant time
multiplied by the number of shares of Preferred Stock requested to be exercised under this Warrant pursuant to such exercise. 

2.     TERM.  

        Except as otherwise provided for herein, the term of this Warrant and the right to purchase Preferred Stock as granted herein (the "Warrant) shall commence on the
Effective Date and shall be exercisable for a period ending upon the later to occur of (i) ten (10) years from the Effective Date; or (ii) five (5) years after the Initial
Public Offering. 

3.     EXERCISE.  

        (a)    Exercise.    The purchase rights set forth in this Warrant are
exercisable by the Warrantholder, in whole or in part, at any time, or from time to time, prior to the expiration of the term set forth in Section 2, by tendering to the Company at its
principal office a notice of exercise in the form attached hereto as Exhibit I (the "Notice of
Exercise"), duly completed and executed. Promptly upon receipt of the Notice of Exercise and the payment of the Purchase Price in accordance with the terms set forth below, and
as soon as practicable thereafter, the Company shall issue to the Warrantholder a certificate for the number of shares of Preferred Stock purchased and shall execute the acknowledgment of exercise in
the form attached hereto as Exhibit II (the "Acknowledgment of Exercise") indicating the number
of shares which remain subject to future purchases, if any. 

        The
Purchase Price may be paid at the Warrantholder's election either (i) by cash or check, or (ii) by surrender of all or a portion of the Warrant for shares of Preferred
Stock to be exercised under this Warrant and, if applicable, an amended Agreement representing the remaining number of shares purchasable hereunder, as determined below ("Net
Issuance"). If the Warrantholder elects the Net Issuance method, the Company will issue Preferred Stock in accordance with the following formula: 

	X =	 	Y(A-B)
 A

	

Where:	
 	

X =	
 	

the number of shares of Preferred Stock to be issued to the Warrantholder.
	

 	
 	

Y =	
 	

the number of shares of Preferred Stock requested to be exercised under this Warrant.
	

 	
 	

A =	
 	

the fair market value of one (1) share of Preferred Stock at the time of issuance of such shares of Preferred Stock.
	

 	
 	

B =	
 	

the Exercise Price.

2

 

        For
purposes of the above calculation, current fair market value of Preferred Stock shall mean with respect to each share of Preferred Stock: 

        (i)    if the exercise is in connection with an Initial Public Offering, and if the Company's Registration Statement relating to
such Initial Public Offering has been declared effective by the SEC, then the fair market value per share shall be the product of (x) the initial "Price to Public" of the Common Stock specified
in the final prospectus with respect to the offering and (y) the number of shares of Common Stock into which each share of Preferred Stock is convertible at the time of such exercise; 

        (ii)   if the exercise is after, and not in connection with, an Initial Public Offering, and: 

        (1)   if the Common Stock is traded on a securities exchange, the fair market value shall be deemed to be the product of
(x) the average of the closing prices over a ten (10) day period ending three days before the day the current fair market value of the securities is being determined and (y) the
number of shares of Common Stock into which each share of Preferred Stock is convertible at the time of such exercise; or 

        (2)   if the Common Stock is actively traded over-the-counter, the fair market value shall be deemed to
be the product of (x) the average of the closing bid and asked prices quoted on the NASDAQ system (or similar system) over the ten (10) day period ending three days before the day the
current fair market value of the securities is being determined and (y) the number of shares of Common Stock into which each share of Preferred Stock is convertible at the time of such
exercise; 

        (iii) if at any time the Common Stock is not listed on any securities exchange or quoted in the NASDAQ National Market or the
over-the-counter market, the current fair market value of Preferred Stock shall be the product of (x) the highest price per share which the Company could obtain from a
willing buyer (not a current employee or director) for shares of Common Stock sold by the Company, from authorized but unissued shares, as most recently determined in good faith by its Board of
Directors and (y) the number of shares of Common Stock into which each share of Preferred Stock is convertible at the time of such exercise, unless the Company shall become subject to a Merger
Event pursuant to which the Company is not the surviving party, in which case the fair market value of Preferred Stock shall be deemed to be the per share value received by the holders of the
Company's Preferred Stock on a common equivalent basis pursuant to such Merger Event. 

        Upon
partial exercise by either cash or Net Issuance, the Company shall promptly issue an amended Agreement representing the remaining number of shares purchasable hereunder. All other
terms and conditions of such amended Agreement shall be identical to those contained herein, including, but not limited to the Effective Date hereof. 

        (b)    Exercise Prior to Expiration.    To the extent this Warrant is
not previously exercised as to all Preferred Stock subject hereto, and if the fair market value of one share of the Preferred Stock is greater than the Exercise Price then in effect, this Warrant
shall be deemed automatically exercised pursuant to Section 3(a) (even if not surrendered) immediately before its expiration. For purposes of such automatic exercise, the fair market value of
one share of the Preferred Stock upon such expiration shall be determined pursuant to Section 3(a). To the extent this Warrant or any portion thereof is deemed automatically exercised pursuant
to this Section 3(b), the Company agrees to promptly notify the Warrantholder of the number of shares of Preferred Stock, if any, the Warrantholder is to receive by reason of such automatic
exercise. 

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4.     RESERVATION OF SHARES.  

        During the term of this Warrant, the Company will at all times have authorized and reserved a sufficient number of shares of its Preferred Stock to provide for
the exercise of the rights to purchase Preferred Stock as provided for herein, and shall have authorized and reserved a sufficient number of shares of its Common Stock to provide for the conversion of
the Preferred Shares available hereunder. 

5.     NO FRACTIONAL SHARES OR SCRIP.  

        No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant, but in lieu of such fractional shares the Company
shall make a cash payment therefor upon the basis of the Exercise Price then in effect. 

6.    REGISTRATION RIGHTS.    The shares of common stock into which the Shares are convertible shall be Registrable Shares, and
Warrantholder shall have the rights of a Holder, pursuant to the Third Amended and Restated Investor Rights Agreement dated as of March 14, 2006, as amended among the Company and the Investors,
as defined therein. 

7.     WARRANTHOLDER REGISTRY.  

        The Company shall maintain a registry showing the name and address of the registered holder of this Warrant. Warrantholder's initial address, for purposes of such
registry, is set forth below Warrantholder's signature on this Warrant. Warrantholder may change such address by giving written notice of such changed address to the Company. 

8.     ADJUSTMENT RIGHTS.  

        The Exercise Price and the number of shares of Preferred Stock purchasable hereunder are subject to adjustment, as follows: 

        (a)    Merger Event.    If at any time there shall be Merger Event,
then, as a part of such Merger Event, lawful provision shall be made so that the Warrantholder shall thereafter be entitled to receive, upon exercise of this Warrant, the number of shares of preferred
stock or other securities or property of the successor corporation resulting from such Merger Event that would have been issuable if Warrantholder had exercised this Warrant immediately prior to the
Merger Event. In any such case, appropriate adjustment (as determined in good faith by the Company's Board of Directors) shall be made in the application of the provisions of this Warrant with respect
to the rights and interests of the Warrantholder after the Merger Event to the end that the provisions of this Warrant (including adjustments of the Exercise Price and number of shares of Preferred
Stock purchasable) shall be applicable in their entirety, and to the greatest extent possible. Without limiting the foregoing, in connection with any Merger Event, upon the closing thereof, the
successor or surviving entity shall assume the obligations of this Warrant. 

        (b)    Reclassification of Shares.    Except as set forth in
Section 8(a), if the Company at any time shall, by combination, reclassification, exchange or subdivision of securities or otherwise, change any of the securities as to which purchase rights
under this Warrant exist into the same or a different number of securities of any other class or classes, this Warrant shall thereafter represent the right to acquire such number and kind of
securities as would have been issuable as the result of such change with respect to the securities which were subject to the purchase rights under this Warrant immediately prior to such combination,
reclassification, exchange, subdivision or other change. 

        (c)    Subdivision or Combination of Shares.    If the Company at any
time shall combine or subdivide its Preferred Stock, (i) in the case of a subdivision, the Exercise Price shall be proportionately decreased, and the number of shares of Preferred Stock
issuable upon exercise of this Warrant shall be proportionately increased, or (ii) in the case of a combination, the Exercise Price shall be 

4

 

proportionately
increased, and the number of shares of Preferred Stock issuable upon the exercise of this Warrant shall be proportionately decreased. 

        (d)    Stock Dividends.    If the Company at any time while this
Warrant is outstanding and unexpired shall: 

        (i)    pay a dividend with respect to the Preferred Stock payable in Preferred Stock, then the Exercise Price shall be adjusted,
from and after the date of determination of shareholders entitled to receive such dividend or distribution, to that price determined by multiplying the Exercise Price in effect immediately prior to
such date of determination by a fraction (A) the numerator of which shall be the total number of shares of Preferred Stock outstanding immediately prior to such dividend or distribution, and
(B) the denominator of which shall be the total number of shares of Preferred Stock outstanding immediately after such dividend or distribution; or 

        (ii)   make any other distribution with respect to Preferred Stock (or stock into which the Preferred Stock is convertible),
except any distribution specifically provided for in any other clause of this Section 8, then, in each such case, provision shall be made by the Company such that the Warrantholder shall
receive upon exercise or conversion of this Warrant a proportionate share of any such distribution as though it were the holder of the Preferred Stock (or other stock for which the Preferred Stock is
convertible) as of the record date fixed for the determination of the shareholders of the Company entitled to receive such distribution. 

        (e)    Antidilution Rights.    Additional antidilution rights
applicable to the Preferred Stock purchasable hereunder are as set forth in the Company's Charter and shall be applicable with respect to the Preferred Stock issuable hereunder. The Company shall
promptly provide the Warrantholder with any restatement, amendment, modification or waiver of the Charter that materially affects the rights of the Preferred Stock;  provided, that no such amendment,
modification or waiver shall impair or reduce the antidilution rights applicable to the Preferred Stock as of the date
hereof unless such amendment, modification or waiver affects the rights of Warrantholder with respect to the Preferred Stock in the same manner as it affects all other holders of Preferred Stock. For
the avoidance of doubt, there shall be no duplicate anti-dilution adjustment pursuant to this subsection (f), the forgoing subsection (d) and the Company's Charter. 

        (f)    Notice of Adjustments.    Whenever an adjustment to the
Exercise Price or the number of shares of Preferred Stock issuable upon exercise of this Warrant is made pursuant to this Section 8, the Company shall send to the Warrantholder a notice setting
forth, in reasonable detail, (i) the event requiring the adjustment, (ii) the amount of such adjustment, (iii) the method by which such adjustment was calculated, (iv) the
adjusted Exercise Price (if the Exercise Price has been adjusted), and (v) the number of shares subject to purchase hereunder after giving effect to such adjustment, and shall cause such notice
to be mailed (by first class mail, postage prepaid, or by reputable overnight courier with all charges prepaid) within thirty (30) days of such adjustment addressed to the Warrantholder at the
address for Warrantholder set forth in the registry referred to in Section 7. 

9.     REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY.  

        (a)    Reservation of Preferred Stock.    The Preferred Stock issuable
upon exercise of the Warrantholder's rights has been duly and validly reserved and, when issued in accordance with the provisions of this Warrant, will be validly issued, fully paid and
non-assessable, and will be free of any taxes, liens, charges or encumbrances of any nature whatsoever; provided, that the Preferred Stock
issuable pursuant to this Warrant may be subject to restrictions on transfer under state and/or federal securities laws and applicable agreements to which the Company or its security holders are
parties. The Company has made available to the Warrantholder true, correct and complete copies of its Charter and current bylaws. The issuance of certificates for shares of Preferred Stock upon
exercise of this Warrant shall be made without charge to the Warrantholder for any issuance tax in respect thereof, or other 

5

 

cost
incurred by the Company in connection with such exercise and the related issuance of shares of Preferred Stock; provided, that the Company shall
not be required to pay any tax which may be payable in respect of any transfer and the issuance and delivery of any certificate in a name other than that of the Warrantholder. 

        (b)    Due Authority.    The execution and delivery by the Company of
this Warrant and the performance of all obligations of the Company hereunder, including the issuance to Warrantholder of the right to acquire the shares of Preferred Stock and the Common Stock into
which it may be converted, have been duly authorized by all necessary corporate action on the part of the Company. This Warrant: (1) is not inconsistent with the Company's Charter or current
bylaws; (2) does not contravene any law or governmental rule, regulation or order applicable to it; and (3) does not and will not contravene any provision of, or constitute a default
under, any indenture, mortgage, contract or other instrument to which it is a party or by which it is bound. This Warrant constitutes a legal, valid and binding agreement of the Company, enforceable
in accordance with its respective terms. 

        (c)    Consents and Approvals.    No consent or approval of, giving of
notice to, registration with, or taking of any other action in respect of any state, federal or other governmental authority or agency is required with respect to the execution, delivery and
performance by the Company of its obligations under this Warrant, except for the filing of notices pursuant to Regulation D under the Act and any filing required by applicable state securities
law, which filings will be effective by the time required thereby. 

        (i)    Issued Securities.    All issued and outstanding shares of
Common Stock, Preferred Stock or any other securities of the Company have been duly authorized and validly issued and are fully paid and nonassessable. All outstanding shares of Common Stock,
Preferred Stock and any other securities were issued in full compliance with all federal and state securities laws. Attached to this Warrant is a true and correct capitalization table of the Company. 

        (d)    Other Commitments to Register Securities.    Except as set
forth in this Warrant and that certain Third Amended and Registration Rights Agreement by and between the Company and the parties named therein dated as of March 14, 2006, as amended, the
Company is not, pursuant to the terms of any other agreement currently in existence, under any obligation to register under the Act any of its presently outstanding securities or any of its securities
which may hereafter be issued. 

        (e)    Exempt Transaction.    Subject to the accuracy of the
Warrantholder's representations in Section 10, the issuance of the Preferred Stock upon exercise of this Warrant, and the issuance of the Common Stock upon conversion of the Preferred Stock,
will each constitute a transaction exempt from (i) the registration requirements of Section 5 of the Act, in reliance upon Section 4(2) thereof, and (ii) the qualification
requirements of the applicable state securities laws. 

        (f)    Compliance with Rule 144.    If the Warrantholder
proposes to sell Preferred Stock issuable upon the exercise of this Warrant, or the Common Stock into which it is convertible, in compliance with Rule 144 promulgated by the SEC, then, upon
Warrantholder's written request to the Company, the Company shall furnish to the Warrantholder, within ten days after receipt of such request, a written statement confirming, if true, the Company's
compliance with the filing requirements of the SEC as set forth in such Rule, as such Rule may be amended from time to time if applicable to the Company. 

10.   REPRESENTATIONS AND COVENANTS OF THE WARRANTHOLDER.  

        This Warrant has been entered into by the Company in reliance upon the following representations and covenants of the Warrantholder: 

        (a)    Investment Purpose.    The right to acquire Preferred Stock or
the Preferred Stock issuable upon exercise of the Warrantholder's rights contained herein will be acquired for its own account for investment and not with a view to the sale or distribution of any
part thereof, and the Warrantholder 

6

 

has
no present intention of selling or engaging in any public distribution of the same except pursuant to a registration or exemption. 

        (b)    Private Issue.    The Warrantholder understands (i) that
the Preferred Stock issuable upon exercise of this Warrant is not registered under the Act or qualified under applicable state securities laws on the ground that the issuance contemplated by this
Warrant will be exempt from the registration and qualifications requirements thereof, and (ii) that the Company's reliance on such exemption is predicated on the representations set forth in
this Section 10. 

        (c)    Disposition of Warrantholder's Rights.    In no event will the
Warrantholder make a disposition of any of its rights to acquire Preferred Stock or Preferred Stock issuable upon exercise of such rights unless and until (i) it shall have notified the Company
of the proposed disposition, and (ii) if requested by the Company, it shall have furnished the Company with an opinion of counsel (which counsel may either be inside or outside counsel to the
Warrantholder) reasonably satisfactory to the Company and its counsel to the effect that (A) appropriate action necessary for compliance with the Act has been taken, or (B) an exemption
from the registration requirements of the Act is available. Notwithstanding the foregoing, the restrictions imposed upon the transferability of any of its rights to acquire Preferred Stock or
Preferred Stock issuable on the exercise of such rights do not apply to transfers from the beneficial owner of any of the aforementioned securities to its nominee or from such nominee to its
beneficial owner, or to any transfers to an Affiliate of Warrantholder, and shall terminate as to any particular share of Preferred Stock when (1) such security shall have been effectively
registered under the Act and sold by the holder thereof in accordance with such registration or (2) such security shall have been sold without registration in compliance with Rule 144
under the Act, or (3) a letter shall have been issued to the Warrantholder at its request by the staff of the SEC or a ruling shall have been issued to the Warrantholder at its request by the
SEC stating that no action shall be recommended by such staff or taken by the SEC, as the case may be, if such security is transferred without registration under the Act in accordance with the
conditions set forth in such letter or ruling and such letter or ruling specifies that no subsequent restrictions on transfer are required. Whenever the restrictions imposed hereunder shall terminate,
as hereinabove provided, the Warrantholder or holder of a share of Preferred Stock then outstanding as to which such restrictions have terminated shall be entitled to receive from the Company, without
expense to such holder, one or more new certificates for this Warrant or for such shares of Preferred Stock not bearing any restrictive legend. 

        (d)    Financial Risk.    The Warrantholder has such knowledge and
experience in financial and business matters as to be capable of evaluating the merits and risks of its investment, and has the ability to bear the economic risks of its investment. 

        (e)    Risk of No Registration.    The Warrantholder understands that
if the Company does not register with the SEC pursuant to Section 12 of the Securities Exchange Act of 1934, as amended (the "1934 Act"), or file
reports pursuant to Section 15(d) of the 1934 Act, or if a registration statement covering the securities under the Act is not in effect when it desires to sell (i) the rights to
purchase Preferred Stock pursuant to this Warrant or (ii) the Preferred Stock issuable upon exercise of the right to purchase, it may be required to hold such securities for an indefinite
period. The Warrantholder also understands that any sale of (A) its rights hereunder to purchase Preferred Stock or (B) Preferred Stock issued or issuable hereunder which might be made
by it in reliance upon Rule 144 under the Act may be made only in accordance with the terms and conditions of that Rule. 

        (f)    Accredited Investor.    Warrantholder is an "accredited
investor" within the meaning of the Securities and Exchange Rule 501 of Regulation D, as presently in effect. 

        (g)    Diligence.    Warrantholder has had an opportunity to discuss
the Company's business, management and financial affairs with its management and an opportunity to review the Company's facilities. 

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11.   TRANSFERS.  

        Subject to the terms and conditions contained in Section 10, this Warrant and all rights hereunder are transferable in whole or in part by the
Warrantholder and any successor transferee. The transfer shall be recorded on the books of the Company upon receipt by the Company of a notice of transfer in the form attached hereto as
Exhibit III (the "Transfer Notice"), at its principal offices and the payment to the Company of all transfer taxes and other governmental charges
imposed on such transfer; provided however that the Warrantholder and any successor transferee agrees not to transfer this Warrant or the Preferred Stock issuable upon exercise of this Warrant to any
competitor of the Company. 

12.   MISCELLANEOUS.  

        (a)    Effective Date.    The provisions of this Warrant shall be
construed and shall be given effect in all respects as if it had been executed and delivered by the Company on the date hereof. This Warrant shall be binding upon any successors or assigns of the
Company. 

        (b)    Remedies.    In the event of any default hereunder, the
non-defaulting party may proceed to protect and enforce its rights either by suit in equity and/or by action at law, including but not limited to an action for damages as a result of any
such default, and/or an action for specific performance for any default where Warrantholder will not have an adequate remedy at law and where damages will not be readily ascertainable. 

        (c)    No Impairment of Rights.    The Company will not, by amendment
of its Charter or through any other means, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of
all such terms and in the taking of all such actions as may be necessary or appropriate in order to protect the rights of the Warrantholder against impairment. 

        (d)    Attorney's Fees.    In any litigation, arbitration or court
proceeding between the Company and the Warrantholder relating hereto, the prevailing party shall be entitled to reasonable attorneys' fees and expenses and all costs of proceedings reasonably incurred
in enforcing this Warrant. For the purposes of this Section 12(d), attorneys' fees shall include without limitation fees reasonably incurred in connection with the following:
(i) contempt proceedings; (ii) discovery; (iii) any motion, proceeding or other activity of any kind in connection with an insolvency proceeding; (iv) garnishment, levy,
and debtor and third party examinations; and (v) post-judgment motions and proceedings of any kind, including without limitation any activity taken to collect or enforce any
judgment. 

        (e)    Entire Agreement; Amendments.    This Warrant constitutes the
entire agreement and understanding of the parties hereto in respect of the subject matter hereof, and supersede and replace in their entirety any prior proposals, term sheets, letters, negotiations or
other documents or agreements, whether written or oral, with respect to the subject matter hereof. None of the terms of this Warrant may be amended except by an instrument executed by each of the
parties hereto. 

        (f)    No Waiver.    No omission or delay by Warrantholder at any time
to enforce any right or remedy reserved to it, or to require performance of any of the terms, covenants or provisions hereof by the Company at any time designated, shall be a waiver of any such right
or remedy to which Warrantholder is entitled, nor shall it in any way affect the right of Warrantholder to enforce such provisions thereafter. 

        (g)    Survival.    All agreements, representations and warranties
contained in this Warrant or in any document delivered pursuant hereto shall be for the benefit of Warrantholder and shall survive the execution and delivery of this Warrant and the expiration or
other termination of this Warrant. 

8

 

        (h)    Governing Law.    This Warrant shall be governed by, and
construed and enforced in accordance with, the laws of the State of Delaware, excluding conflict of laws principles that would cause the application of laws of any other jurisdiction. 

        (i)    Consent to Jurisdiction and Venue.    All judicial proceedings
arising in or under or related to this Warrant may be brought in any state or federal court of competent jurisdiction located in the State of California. By execution and delivery of this Warrant,
each party hereto generally and unconditionally: (a) consents to personal jurisdiction in Santa Clara County, California; (b) waives any objection as to jurisdiction or venue in Santa
Clara County, California; (c) agrees not to assert any defense based on lack of jurisdiction or venue in the aforesaid courts; and (d) irrevocably agrees to be bound by any judgment
rendered thereby in connection with this Warrant. Nothing herein shall affect the right to serve process in any other manner permitted by law or shall limit the right of either party to bring
proceedings in the courts of any other jurisdiction. 

        (j)    Mutual Waiver of Jury Trial.    Because disputes arising in
connection with complex financial transactions are most quickly and economically resolved by an experienced and expert person and the parties wish applicable state and federal laws to apply (rather
than arbitration rules), the parties desire that their disputes arising out of this Warrant be resolved by a judge applying such applicable laws. EACH OF THE COMPANY AND WARRANTHOLDER SPECIFICALLY
WAIVES ANY RIGHT IT MAY HAVE TO TRIAL BY JURY OF ANY CAUSE OF ACTION, CLAIM, CROSS-CLAIM, COUNTERCLAIM, THIRD PARTY CLAIM OR ANY OTHER CLAIM (COLLECTIVELY, "CLAIMS") ASSERTED BY THE COMPANY AGAINST
WARRANTHOLDER OR ITS ASSIGNEE OR BY WARRANTHOLDER OR ITS ASSIGNEE AGAINST THE COMPANY. If this jury waiver is for any reason unenforceable, all disputes shall be resolved by judicial reference under
California Code of Civil Procedure Section 638. 

        (k)    Specific Performance.    Warrantholder and Company agree that
either may be irreparably damaged by any breach or threatened breach of this Warrant. Upon a breach or threatened breach of the terms, covenants and/or conditions of this Warrant by Warrantholder or
Company, the other party shall, in addition to all other remedies, be entitled to seek a temporary or permanent injunction and/or a decree for specific performance, in accordance with the provisions
hereof. Warrantholder and Company each waives the claim or defense that it has an adequate remedy at law, and such person shall not offer in any such action or proceeding the claim or defense that
such remedy at law exists. 

        (l)    No Shareholder Rights.    This Warrant does not entitle the
Warrantholder to any voting rights or other rights as a shareholder of the Company prior to the exercise of this Warrant. 

        (m)    Counterparts.    This Warrant and any amendments, waivers,
consents or supplements hereto may be executed in any number of counterparts, and by different parties hereto in separate counterparts, each of which when so delivered shall be deemed an original, but
all of which counterparts shall constitute but one and the same instrument. 

[Remainder
of Page Intentionally Left Blank] 

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        IN
WITNESS WHEREOF, the parties hereto have caused this Warrant to be executed by its officers thereunto duly authorized as of the Effective Date. 

	COMPANY:	 	SIRTRIS PHARMACEUTICALS, INC.
	

 	
 	

By:	

/s/  GAREN BOHLIN      
 Name: Garen Bohlin

Title: Chief Operating Officer
	

 	
 	

Attn: Paul Brannelly

790 Memorial Drive, Suite 104

Cambridge, MA 02139
	

WARRANTHOLDER:	
 	
HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
	

 	
 	

By:	

/s/  SCOTT HARVEY      
 Title: CHIEF LEGAL OFFICER
	

 	
 	

Hercules Technology Growth Capital, Inc.

Attn: Parag Shah

2 Oliver Street, Suite 611

Boston, MA 02109
	

cc:	
 	

Hercules Technology Growth Capital, Inc.

Attn: Chief Legal Officer

525 University Avenue

Suite 700

Palo Alto, CA 94301

10

 
EXHIBIT I  

 NOTICE OF EXERCISE  

To:
Sirtris Pharmaceuticals, Inc. 

	(1)
	The
undersigned Warrantholder hereby elects to purchase [            ] shares of the Series C Preferred Stock of Sirtris
Pharmaceuticals, Inc., pursuant to the terms of the Warrant dated April 17, 2006 (the "Warrant") between Sirtris Pharmaceuticals, Inc. and the Warrantholder, and [CASH
PAYMENT: tenders herewith payment of the Purchase Price in full, together with all applicable transfer taxes, if any.] [NET ISSUANCE: elects pursuant to Section 3(a) of
the Agreement to effect a Net Issuance.]

	(2)
	In
exercising its rights to purchase the Series C Preferred Stock of Sirtris Pharmaceuticals, Inc., the undersigned hereby confirms and acknowledges the investment
representations and warranties made in Section 10 of the Agreement.

	(3)
	Please
issue a certificate or certificates representing said shares of Series C Preferred Stock in the name of the undersigned or in such other name as is specified below. 

	 	 	
 (Name)
	

 	
 	

 (Address)
	

WARRANTHOLDER:	
 	
HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
	

 	
 	

By:	

	

 	
 	

Title:	

	

 	
 	

Date:	

11

 
EXHIBIT II  

 ACKNOWLEDGMENT OF EXERCISE  

The
undersigned Sirtris Pharmaceuticals, Inc., hereby acknowledge receipt of the "Notice of Exercise" from Hercules Technology Growth Capital, Inc., to purchase
[            ] shares of the Series C Preferred Stock of Sirtris Pharmaceuticals, Inc., pursuant to the terms of the Agreement, and further acknowledges that
[            ] shares remain subject to purchase under the terms of the Agreement. 

	COMPANY:	 	SIRTRIS PHARMACEUTICALS, INC.
	

 	
 	

By:	

	

 	
 	

Title:	

	

 	
 	

Date:	

12

 
EXHIBIT III  

 TRANSFER NOTICE  

(To
transfer or assign the foregoing Agreement execute this form and supply required information. Do not use this form to purchase shares.) 

FOR
VALUE RECEIVED, the foregoing Agreement and all rights evidenced thereby are hereby transferred and assigned to 

	
 (Please Print)

	

whose address is	
 	

	

	

Dated:	
 	

	

Holder's Signature:	
 	

	

Holder's Address:	
 	

	

13

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Exhibit 10.9QuickLinks
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Exhibit 10.10    
    

THIS
WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, PLEDGED, OR OTHERWISE
TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER SUCH ACT AND LAWS OR, SUBJECT TO SECTION 5.3 HEREOF, AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE CORPORATION AND ITS COUNSEL, THAT
SUCH REGISTRATION IS NOT REQUIRED. 

WARRANT TO PURCHASE STOCK 

Issuer:
Sirtris Pharmaceuticals, Inc., a Delaware corporation

Number of Shares: As set forth below

Class of Stock: Series B Convertible Preferred Stock, $0.001 par value per share

Exercise Price: $0.80 per share, subject to adjustment

Issue Date: June 23, 2006

Expiration Date: June 23, 2016 

        FOR
THE AGREED UPON VALUE of $1.00, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, this Warrant is issued to SILICON VALLEY
BANK (together with its successors and permitted assigns, "Holder") by Sirtris Pharmaceuticals, Inc., a Delaware corporation (the "Company"). 

        Subject
to the terms and conditions hereinafter set forth, the Holder is entitled upon surrender of this Warrant and a duly executed Notice of Exercise in substantially the form attached
hereto as Appendix 1 (the "Notice of Exercise"), at the principal office of the Company, 790 Memorial Drive, Suite 104, Cambridge, Massachusetts
02139 or such other office as the Company shall notify the Holder of in writing, to purchase from the Company up to the amount fully paid and non-assessable shares of the Company's
Series B Convertible Preferred Stock, $0.001 par value per share (the "Class") set forth below, at a purchase price per Share of Eighty Cents ($0.80) (the "Exercise Price"). Subject to
adjustment as set forth herein, this Warrant shall be exercisable for such number of shares of the Class
(the "Shares") as shall equal (a) (i) one and one-third percent (1.33%) multiplied by (ii) the aggregate principal amount of all Equipment Advances (as defined in that
certain Loan and Security Agreement of even date herewith among the Company and Silicon Valley Bank (the "Loan Agreement")), made to the Company pursuant to the Loan Agreement, divided by
(b) the Exercise Price. This Warrant may be exercised in whole or in part at any time and from time to time until 5:00 PM, Eastern time, on the Expiration Date set forth above, and shall be
void thereafter. Until such time as this Warrant is exercised in full or expires, the Exercise Price and the number of Shares are subject to adjustment from time to time as hereinafter provided. 

        Notwithstanding
the foregoing definition of Class, upon and after the automatic or voluntary conversion, redemption or retirement of all (but not less than all) of the outstanding shares
of such Class, including without limitation the Company's initial registered underwritten public offering and sale of its securities ("IPO"), then from and after the date upon which all such
outstanding shares have been so converted, redeemed or retired, "Class" shall mean the Company's common stock, $0.001 par value per share ("Common Stock"), and this Warrant shall be exercisable for
such number of shares of Common Stock as shall equal the number of shares of Common Stock into which the Shares would have been converted pursuant to the Company's Certificate of Incorporation, as
amended, including without limitation the Certificate of Designation, if any, applicable to the same class or series of preferred stock as the Shares (the "Certificate") had the Shares been issued and
outstanding immediately prior to such conversion, redemption or retirement, and the Exercise Price shall be the Common Stock conversion price as determined pursuant to the Certificate immediately
prior to such conversion, redemption or retirement (all subject to further adjustment as provided herein). 

ARTICLE 1.    EXERCISE. 

 

        1.1    Method of Exercise.    Holder may exercise this Warrant by delivering this Warrant together with a duly
executed Notice of Exercise to the principal office of the Company. Unless Holder is exercising the conversion right set forth in Section 1.2, Holder shall also deliver to the Company a check
for the aggregate Exercise Price for the Shares being purchased. 

        1.2    Conversion Right.    In lieu of exercising this Warrant as specified in Section 1.1, Holder may from
time to time convert this Warrant, in whole or in part, into a number of Shares determined as follows:

	 	 	X	 	=	 	Y (A-B)/A

        where:

	 	 	X	 	=	 	the number of Shares to be issued to the Holder.
	

 	
 	

Y	
 	

=	
 	

the number of Shares with respect to which this Warrant is being exercised.
	

 	
 	

A	
 	

=	
 	

the fair market value (as determined pursuant to Section 1.3 below) of one Share.
	

 	
 	

B	
 	

=	
 	

the Exercise Price.

        1.3    Fair Market Value.    

        1.3.1     If
shares of the Class (or shares of the Company's stock into which shares of the Class are convertible or exchangeable) are traded on a nationally
recognized securities exchange or over the counter market, the fair market value of a Share shall be the closing price of a share of the Class (or the closing price of a share of the Company's stock
for which shares of the Class are convertible or exchangeable, multiplied by the number of shares of such stock into which one share of the Class is convertible or exchangeable) reported for the
business day immediately preceding the date of Holder's Notice of Exercise to the Company. 

        1.3.2     If
shares of the Class (or shares of the Company's stock into which shares of the Class are convertible or exchangeable) are not traded on a nationally
recognized securities exchange or over the counter market, the Board of Directors of the Company shall determine fair market value in its reasonable good faith judgment. 

        1.4    Delivery of Certificate and New Warrant.    Promptly after Holder exercises or converts this Warrant, the
Company at its sole expense shall promptly deliver to Holder (i) certificates for the Shares acquired upon such exercise, and (ii) if this Warrant has not been fully exercised or
converted and has not expired, a new warrant of like tenor representing the Shares for which this Warrant is still exercisable. 

        1.5    Replacement of Warrants.    On receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and amount to the Company or, in the
case of mutilation, on surrender and cancellation of this Warrant, the Company at its expense shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor. 

        1.6    Assumption on Sale, Merger, or Consolidation of the Company.    

        1.6.1.    "Acquisition".    For the purpose of this Warrant, "Acquisition" means any sale, assignment, transfer,
exclusive license, or other disposition of all or substantially all of the assets of the Company, or any acquisition, reorganization, consolidation, or merger of the Company where the holders of the
Company's outstanding voting equity securities immediately prior to the transaction beneficially own less than a majority of the outstanding voting equity securities of the surviving or successor
entity immediately following the transaction. 

2

 

        1.6.2.    Assumption of Warrant.    Upon the closing of any Acquisition (other than an Acquisition in which the
consideration received by the Company's stockholders consists solely of cash and/or cash equivalents), and as a condition precedent thereto, the successor or surviving entity shall assume the
obligations of this Warrant, and this Warrant shall be exercisable for the same securities and property as would be payable for the Shares issuable upon exercise of the unexercised portion of this
Warrant as if such Shares were outstanding on the record date for the Acquisition and subsequent closing. The Exercise Price shall be adjusted accordingly, and the Exercise Price and number and class
of Shares shall continue to be subject to adjustment from time to time in accordance with the provisions hereof. Upon the closing of any Acquisition in which the consideration received by the
Company's stockholders consists solely of cash and/or cash equivalents, then, to the extent not exercised or converted on or before the closing of such Acquisition, this Warrant shall terminate and be
of no further force or effect. 

ARTICLE
2.    ADJUSTMENTS TO THE SHARES. 

        2.1    Stock Dividends, Splits, Etc.    If the Company declares or pays a dividend on the outstanding shares of the
Class, payable in shares of the Class, Common Stock or other securities, or subdivides the outstanding shares of the Class into a greater number of shares of the Class, or subdivides the shares of the
Class in a transaction that increases the amount of Common Stock into which such shares are convertible, then upon exercise of this Warrant, for each Share acquired, Holder shall receive, without
additional cost to Holder, the total number and kind of securities to which Holder would have been entitled had Holder owned the Shares of record as of the date the dividend or subdivision occurred. 

        2.2    Reclassification, Exchange or Substitution.    Upon any reclassification, exchange, substitution,
reorganization or other event that results in a change of the number and/or class of the securities issuable upon exercise or conversion of this Warrant, Holder shall be entitled to receive, upon
exercise or conversion of this Warrant, the number and kind of securities and property that Holder would have received for the Shares if this Warrant had been exercised immediately before such
reclassification, exchange, substitution, reorganization or other event. The Company or its successor shall promptly issue to Holder a new warrant of like tenor for such new securities or other
property. The new warrant shall provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments provided for in this Article 2 including, without
limitation, adjustments to the Exercise Price and to the number of securities or property issuable upon exercise of the new warrant. The provisions of this Section 2.2 shall similarly apply to
successive reclassifications, exchanges, substitutions, reorganizations or other events. 

        2.3    Adjustments for Combinations, Etc.    If the outstanding shares of the Class are combined or consolidated, by
reclassification or otherwise, into a lesser number of shares, the Exercise Price shall be proportionately increased and the number of Shares issuable upon exercise or conversion of this Warrant shall
be proportionately decreased. 

        2.4    No Impairment.    The Company shall not, by amendment of the Certificate or its by-laws or through
a reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms to be observed or performed under this Warrant by the Company, but shall at all times in good faith assist in carrying out of all the provisions of this Article 2 and in taking all such
action as may be necessary or appropriate to protect Holder's rights under this Article against impairment. 

        2.5    Adjustments for Dilutive Issuances.    The number of shares of Common Stock for which the Shares are
convertible shall be adjusted from time to time in accordance with Section 2(e) of Article IV of the Certificate as if the Shares were issued and outstanding on and as of the date of any
such required adjustment. 

3

 

        2.6    Fractional Shares.    No fractional Shares shall be issuable upon exercise or conversion of the Warrant and the
number of Shares to be issued shall be rounded down to the nearest whole Share. If a fractional Share interest arises upon any exercise or conversion of this Warrant, the Company shall eliminate such
fractional Share interest by paying Holder an amount computed by multiplying such fractional interest by the fair market value (determined in accordance with Section 1.3 above) of one Share. 

        2.7    Certificate as to Adjustments.    Upon each adjustment of the Exercise Price, number or class of Shares or
number of shares of Common Stock or other securities for which the Shares are convertible or exchangeable, the Company at its expense shall promptly compute such adjustment, and furnish Holder with a
certificate of its chief financial officer setting forth such adjustment and the facts upon which such adjustment is based. The Company shall at any time and from time to time, upon written request,
furnish Holder with a certificate setting forth the Exercise Price, number and class of Shares and conversion ratio in effect upon the date thereof and the series of adjustments leading to such
Exercise Price, number and class of Shares and conversion ratio. 

ARTICLE
3.    REPRESENTATIONS AND COVENANTS OF THE COMPANY. 

        3.1    Representations and Warranties.    The Company hereby represents and warrants to the Holder as follows: 

        (a)   All
Shares which may be issued upon the due exercise of this Warrant, and all Common Stock or other securities, if any, issuable upon due conversion of the Shares,
shall, upon issuance, be duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or
under applicable federal and state securities laws. 

        (b)   The
Company covenants that it shall at all times cause to be reserved and kept available out of its authorized and unissued shares such number of shares of the Class and
shares of its Common Stock
and other securities as will be sufficient to permit the exercise in full of this Warrant and the conversion of the Shares into shares of Common Stock or such other securities. 

        (c)   On
and as of the date hereof, (i) $0.80 is the lowest price per share for which shares of the Class have been sold or issued by the Company, and the lowest
exercise or conversion price per share for which shares of the Class may be purchased or acquired upon the exercise or conversion of outstanding securities exercisable or convertible by their terms
for shares of the Class, and (ii) the Common Stock conversion price in effect for shares of the Class as determined pursuant to the Certificate is $0.80. 

        (d)   The
execution and delivery by the Company of this Warrant and the performance of all obligations of the Company hereunder, including the issuance to Holder of the Shares
upon exercise or conversion hereof, (i) have been duly authorized by all necessary corporate action on the part of the Company, its Board of Directors and stockholders, (ii) do not
conflict with or violate the Certificate and/or the Company's by-laws, (iii) do not contravene any law or governmental rule, regulation or order applicable to it, and (iv) do
not contravene any provision of, or constitute a default under, any material indenture, mortgage, contract or other instrument to which it is a party or by which it is bound. This Warrant constitutes
the legal, valid and binding agreement of the Company, enforceable in accordance with its terms. 

        3.2    Notice of Certain Events.    If the Company proposes at any time (a) to declare any dividend or
distribution upon any of its capital stock, whether in cash, property, stock, or other securities and whether or not a regular cash dividend; (b) to offer for subscription pro rata to the
holders of any class or series of its stock any additional shares of stock of any class or series or other rights; (c) to effect any reclassification or recapitalization of any of its
securities; or (d) to merge or consolidate with or into any other corporation, or sell, lease, license, or convey all or substantially all of its assets, or to 

4

 

liquidate,
dissolve or wind up; then, in connection with each such event, the Company shall give Holder (1) at least 20 days prior written notice of the date on which a record will be
taken for such dividend, distribution, or subscription rights (and specifying the date on which the holders of securities of the Company shall be entitled to receive such dividend, distribution or
rights) or for determining rights to vote, if any, in respect of the matters referred to in (c) and (d) above; and (2) in the case of the matters referred to in (c) and
(d) above at least 20 days prior written notice of the date when the same will take place (and specifying the date on which the holders of securities of the Company will be entitled to
exchange their securities of the Company for securities or other property deliverable upon the occurrence of such event). 

        3.3    Registration Under Securities Act of 1933, as amended.    The shares of Common Stock issuable upon conversion
of the Shares (and the Shares, at all times when the Class is Common Stock) shall have certain incidental or "piggyback" and "S-3" registration rights pursuant to, and as set forth in,
that certain Third Amended and Restated Registration Rights Agreement dated as of March 14, 2006 among the Company and the other parties named therein. The Company shall execute and deliver an
amendment or joinder agreement with Holder for the purpose of effecting the foregoing
grant of registration rights. The Company represents and warrants to Holder that the Company's foregoing grant of registration rights and its execution, delivery and performance of the aforementioned
amendment or joinder agreement (a) have been duly authorized by all necessary corporate action of the Company's Board of Directors and shareholders, (b) will not violate the Certificate
or the Company's by-laws, each as amended, (c) will not violate or cause a breach or default (or an event which with the passage of time or the giving of notice or both, would
constitute a breach or default) under any agreement, instrument, mortgage, deed of trust or other arrangement to which the Company is a party or by which it or any of its assets is subject or bound,
and (d) do not require the approval, consent or waiver of or by any shareholder, registration rights holder or other third party which approval, consent or waiver has not been obtained as of
the date of issuance of this Warrant. 

ARTICLE
4.    REPRESENTATIONS AND WARRANTIES OF THE HOLDER.    Holder represents and warrants to the Company as follows: 

        4.1    Purchase for Own Account.    Subject to Silicon Valley Bank's right to transfer this Warrant and the Shares
(and/or the securities, if any, issued and issuable upon conversion of the Shares) to its parent corporation SVB Financial Group and/or any other affiliate, this Warrant and the Shares to be acquired
upon exercise hereof will be acquired for investment for Holder's account, not as nominee or agent, and not with a view to sale or distribution in violation of applicable federal and state securities
laws. 

        4.2    Investment Experience.    Holder understands that the purchase of this Warrant and the Shares covered hereby
involves substantial risk. Holder (a) has experience as an investor in unregistered securities, (b) has sufficient knowledge and experience in financial and business affairs that it can
evaluate the risks and merits of its investment in this Warrant and the Shares, and (c) can bear the economic risk of such Holder's investment in this Warrant and the Shares. 

        4.3    Accredited Investor.    Holder is an "accredited investor" as such term is defined in Regulation D under
the Securities Act of 1933, as amended (the "Act"). 

ARTICLE
5.    MISCELLANEOUS. 

        5.1    Automatic Conversion upon Expiration.    In the event that, upon the Expiration Date, the Fair Market Value of
one Share (or other security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Exercise Price in effect on such date, then this Warrant
shall automatically be deemed on and as of such date to be converted pursuant to Section 1.2 above as to all Shares (or such other securities) for which it shall not previously have been
exercised or 

5

 

converted,
and the Company shall promptly deliver a certificate representing the Shares (or such other securities) issued upon such conversion to the Holder. 

        5.2    Legends.    This Warrant and the Shares (and the securities issuable, directly or indirectly, upon conversion
of the Shares, if any) shall be imprinted with a legend in substantially the following form: 

THIS
SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE
REGISTRATION THEREOF UNDER SUCH ACT AND LAWS OR, SUBJECT TO SECTION 5.3 OF THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE CORPORATION TO SILICON VALLEY BANK DATED AS
OF                        , 2006, AN
OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE CORPORATION AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

        5.3    Compliance with Securities Laws on Transfer.    This Warrant and the Shares (and the securities, if any, issued
and issuable upon conversion of the Shares) may not be transferred or assigned in whole or in part without compliance with applicable federal and state securities laws by the transferor and the
transferee (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The
Company shall not require Holder to provide an opinion of counsel if the transfer is to SVB Financial Group or other affiliate of Holder, provided that such transferee is an "accredited investor" as
defined in Regulation D promulgated under the Act. 

        5.4    Transfer Procedure.    Following its receipt of this executed Warrant, Silicon Valley Bank will transfer same
in whole or in part to its parent corporation SVB Financial Group, and thereafter Holder and/or SVB Financial Group may, subject to Section 5.3 above, transfer all or part of this Warrant
and/or the Shares (or the securities, if any, issued and issuable upon conversion of the Shares) at any time and from time to time by giving the Company notice of the portion of the Warrant and/or
Shares (or the securities, if any, issued and issuable upon conversion of the Shares) being transferred setting forth the name, address and taxpayer identification number of the transferee and
surrendering this Warrant to the Company for reissuance to the transferee(s) (and Holder if applicable); provided, that at all times prior to the
Company's IPO, Holder shall not, without the prior written consent of the Company, transfer this Warrant (or any part hereof), any Shares, or any securities issued or issuable upon conversion of the
Shares, to any person who directly competes with the Company, unless such transfer is in connection with an Acquisition of the Company by any such person. 

        5.5    Notices.    All notices and other communications from the Company to the Holder, or vice versa, shall be deemed
delivered and effective when given personally, or mailed by first-class registered or certified mail, postage prepaid, or sent via reputable overnight courier service, fee prepaid, at such address as
may have been furnished to the Company or the Holder, as the case may be, in writing by the Company or such holder from time to time, but in all cases, unless instructed in writing otherwise, the
Company shall deliver a copy of all notices to Holder to Silicon Valley Bank, Treasury Department, 3003 Tasman Drive, HA 200, Santa Clara, California 95054. 

        5.6    Waiver.    This Warrant and any term hereof may be changed, waived, discharged or terminated only by an
instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 

        5.7    Attorneys Fees.    In the event of any dispute between the parties concerning the terms and provisions of this
Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys' fees. 

6

 

        5.8    Governing Law.    This Warrant shall be governed by and construed in accordance with the laws of the
Commonwealth of Massachusetts, without giving effect to its principles regarding conflicts of law. 

        5.9    No Rights as a Shareholder.    Except as specifically provided in this Warrant, Holder shall have no rights as
a shareholder of the Company in respect of the Shares issuable hereunder unless and until Holder exercises this Warrant as to all or any of such Shares. 

[REMAINDER
OF PAGE LEFT BLANK INTENTIONALLY] 

7

 

        IN
WITNESS WHEREOF, the Company has caused this Warrant to Purchase Stock to be executed as an instrument under seal by its duly authorized representative as of the date first above
written. 

	 	 	"COMPANY"
	 	 	 	 	 
	 	 	 	 	 
	 	 	SIRTRIS PHARMACEUTICALS, INC.
	 	 	 	 	 
	 	 	By:	 	/s/  GAREN BOHLIN      

	 	 	Name:	 	Garen Bohlin
	 	 	Title:	 	Chief Operating Officer

8

   APPENDIX 1  

 NOTICE OF EXERCISE  

        1.     The
undersigned hereby elects to purchase            shares of
the                        stock
of                        pursuant to Section 1.1 of the attached Warrant,
and tenders herewith payment of the Exercise Price of such shares in full. 

        1.     The
undersigned hereby elects to convert the attached Warrant into Shares in the manner specified in Section 1.2 of the attached Warrant. This conversion is
exercised with respect to                        of shares of
the                        Stock
of                        . 

        [Strike
paragraph that does not apply.] 

        2.     Please
issue a certificate or certificates representing said shares in the name of the undersigned or in such other name as is specified below: 

	    
 (Name)
	    
    
 (Address)

        3.     The
undersigned represents it is acquiring the shares solely for its own account and not as a nominee for any other party and not with a view toward the resale or
distribution thereof except in compliance with applicable securities laws. 

	 	 	 	    
 (Signature)
	

    
 (Date)	
 	

 	

 

10

 
APPENDIX 2 

ASSIGNMENT  

For
value received, Silicon Valley Bank hereby sells, assigns and transfers unto 

	Name:	 	SVB Financial Group
	

Address:	
 	

3003 Tasman Drive (HA-200)
	

 	
 	

Santa Clara, CA 95054
	

Tax ID:	
 	

91-1962278

that
certain Warrant to Purchase Stock issued by Sirtris Pharmaceuticals, Inc. (the "Company"),
on                            , 2006 (the "Warrant") together with all rights, title and
interest therein. 

	 	 	 	SILICON VALLEY BANK	 
	

 	
 	

 	

 	
 	

By:	

    

	

 	
 	

 	

 	
 	

Name:	

    

	

 	
 	

 	

 	
 	

Title:	

    

	

Date:	
 	

[insert Issue Date]	

 	
 	

 	

 
	 	 	 	
	 	 	 

        By
its execution below, and for the benefit of the Company, SVB Financial Group makes each of the representations and warranties set forth in Article 4 of the Warrant as of the
date hereof. 

	 	 	SVB FINANCIAL GROUP
	

 	
 	

By:	

    

	

 	
 	

Name:  Paulette Mehas
	

 	
 	

Title:    Treasurer

11

QuickLinks

Exhibit 10.10

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