Document:

EX-10.22

			
	

	  	 Exhibit 10.22
  

 
 Deferral Agreement

 

					
	Deferral Agreement Effective Date:	  		  	April 2, 2020
			
	Loan Agreement Date (use restated date if applicable):	  		  	September 23, 2019
			
	Borrower:	  		  	SPRUCE BIOSCIENCES, INC.                            
			
		  	☐	  	If this box is checked, additional Borrowers (“Additional Borrowers”) are listed in the Annex attached hereto (Borrower and such Additional Borrowers, collectively, “Borrower”).
			
	Loan Agreement:	  		  	That certain Loan and Security Agreement, dated as of the Loan Agreement Date, between Borrower, Additional Borrowers, if any, and Silicon Valley Bank (“Bank”), as amended, restated or otherwise modified and in
effect from time to time.
			
	Guarantor(s) or Pledgor(s):	  	☐	  	If this box is checked, the obligations of Borrower are guaranteed or secured by a pledge of assets and the Consent and Ratification attached hereto shall apply and must be completed for each Guarantor and/or Pledgor.

 Reference is made to the Loan Agreement and the other terms defined herein. Borrower and Bank hereby agree to the Terms and
Conditions attached hereto and any applicable Annex and/or Consent and Ratification attached hereto, each of which is incorporated herein by reference (collectively, the “Deferral Agreement”). 

 

			
	 BANK:
  

SILICON VALLEY BANK
  

By: /s/ Shawn
Parry                            

 
 Shawn
Parry                                        

 Name
  

Managing
Director                            

Title
	  	 BORROWER:
  

SPRUCE BIOSCIENCES,
INC.                                         
   
  
 By: /s/ Richard
King                                         
                     
  

Richard
King                                         
                                 

Name
  

Chief Executive
Officer                                        
                
 Title

 

By:                         
                                         
                      
                                         
                                         
            
 Name

                          
                                         
                           
Title

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 1 of 6

			
	

	  	 Terms and Conditions

Deferral Agreement

  

	1.	 Definitions. Capitalized terms used but not defined herein shall have the meanings ascribed to such
terms in the Loan Agreement. 

  

	2.	 Interest Payments. Borrower shall at all times continue to make regularly scheduled monthly payments of
accrued interest on each applicable payment date under the Loan Agreement. 

  

	3.	 Extension of Principal Payment Dates. 

 

	 	a.	 The payment dates for all monthly payments of principal in respect of any term loans (but not any other
facilities) which are due following the Deferral Agreement Effective Date shall each be extended by six (6) months. 

  

	 	b.	 To the extent that the Loan Agreement permits Borrower to extend the period during which Borrower is only
required to make payments of accrued interest (and no principal payments) (the “Interest Only Period”) upon achieving one or more milestones or other thresholds, which milestones or thresholds have not yet been achieved as of the
Deferral Agreement Effective Date, by execution of the Deferral Agreement, Borrower agrees that (a) the six (6) month extension of the Interest Only Period provided for by this Deferral Agreement shall supersede and replace any and all
extensions of the Interest Only Period set forth in the Loan Agreement, and (b) any and all extensions of the Interest Only Period set forth in the Loan Agreement as of the Deferral Agreement Effective Date are hereby void, and shall be of no
further force and effect. Nothing herein shall be construed as a modification or amendment of the existing terms and conditions in the Loan Agreement that provide for Bank to increase availability or to make additional advances or extensions of
credit to Borrower, including if such increase or additional advances or extensions of credit require Borrower to achieve the same milestone or threshold that would have previously extended the Interest Only Period prior to Borrower entering into
this Deferral Agreement. 

  

	 	c.	 The amount of each monthly payment of principal following the extension shall be the same as the amount of the
scheduled monthly payment of principal prior to the Deferral Agreement Effective Date. 

  

	 	d.	 All deferred principal payments shall continue to be secured by all Collateral granted or pledged to Bank under
the Loan Documents. 

	4.	 Extension of Maturity Date. The maturity date(s) for all term loans (but not any other facilities) under
the Loan Agreement that occur after the Deferral Agreement Effective Date shall be extended by six (6) months, and the corresponding definitions of such maturity dates in the Loan Agreement shall be deemed to be amended accordingly.

  

	5.	 Representations and Warranties. Borrower hereby represents and warrants that (a) Borrower has the
power and authority to execute and deliver to Bank the Deferral Agreement, (b) the execution and delivery to Bank by Borrower of the Deferral Agreement and the performance of Borrower’s obligations under the Loan Agreement, as amended by
the Deferral Agreement, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority, or subdivision thereof, binding on
Borrower, except as already has been obtained or made and (c) the Deferral Agreement has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except
as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization or similar laws and equitable principals relating to or affecting creditors rights. 

 

	6.	 Ratification. Borrower hereby ratifies, confirms, and reaffirms all terms and conditions of all Loan
Documents and all security or other collateral granted to Bank, and confirms that the indebtedness secured thereby includes, without limitation, the Obligations and all deferred principal payments. 

 

	7.	 Release. For good and valuable consideration, Borrower hereby forever relieves, releases, and discharges
Bank and its present or former employees, officers, directors, agents, representatives, attorneys, and each of them, from any and all claims, debts, liabilities, demands, obligations, promises, acts, agreements, costs and expenses, actions and
causes of action, of every type, kind, nature, description or character whatsoever, whether known or unknown, suspected or unsuspected, absolute or contingent, arising out of or in any manner whatsoever connected with or related to facts,
circumstances, issues, controversies or claims existing or arising from the beginning of time through and including the date of execution hereof (collectively “Released Claims”). Without limiting the foregoing, the Released Claims
shall include any and all liabilities or claims arising out of or in any manner whatsoever connected with or related to the Loan Documents, any instruments, agreements or documents executed in connection with any of the

 

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 2 of 6

			
	

	  	 Terms and Conditions

Deferral Agreement

  

 
foregoing or the origination, negotiation, administration, servicing or enforcement of any of the foregoing. Borrower expressly acknowledges and waives any and all rights under Section 1542
of the California Civil Code, which provides that: 
 “A general release does not extend to claims that the creditor or releasing
party does not know or suspect to exist in his or her favor at the time of executing the release and that, if known by him or her, would have materially affected his or her settlement with the debtor or released party.” 

By entering into this release, Borrower recognizes that no facts or representations are ever absolutely certain and it may hereafter discover
facts in addition to or different from those which it presently knows or believes to be true, but that it is the intention of Borrower hereby to fully, finally and forever settle and release all matters, disputes and differences, known or unknown,
suspected or unsuspected; accordingly, if Borrower should subsequently discover that any fact that it relied upon in entering into this release was untrue, or that any understanding of the facts was incorrect, Borrower shall not be entitled to set
aside this release by reason thereof, regardless of any claim of mistake of fact or law or any other circumstances whatsoever. Borrower acknowledges that it is not relying upon and has not relied upon any representation or statement made by Bank
with respect to the facts underlying this release or with regard to any of such party’s rights or asserted rights. This release may be pleaded as a full and complete defense and/or as a cross-complaint or counterclaim against any action, suit,
or other proceeding that may be instituted, prosecuted or attempted in breach of this release. Borrower acknowledges that the release contained herein constitutes a material inducement to Bank to enter into the Deferral Agreement, and that Bank
would not have done so but for Bank’s expectation that such release is valid and enforceable in all events. Borrower hereby represents and warrants to Bank, and Bank is relying thereon, that (a), except as expressly stated herein, neither Bank
nor any agent, employee or representative of Bank has made any statement or representation to Borrower regarding any fact relied upon by Borrower in entering into the Deferral Agreement, (b) Borrower has made such investigation of the facts
pertaining hereto and all of the matters appertaining thereto, as it deems necessary; (c) the terms hereof are contractual and not a mere recital; (d) the Deferral Agreement has been carefully read by Borrower, the contents hereof are
known and understood by Borrower, and the Deferral Agreement is signed freely, and without duress, by Borrower and (e) Borrower represents and warrants that it is the sole and lawful owner of all right,

 
title and interest in and to every claim and every other matter which it releases herein, and that it has not heretofore assigned or transferred, or purported to assign or transfer, to any
person, firm or entity any claims or other matters herein released. Borrower shall indemnify Bank, defend and hold it harmless from and against all claims based upon or arising in connection with prior assignments or purported assignments or
transfers of any claims or matters released herein. 
  

	8.	 Full Force and Effect; Limitations of Deferral Agreement. Other than as expressly provided in the
Deferral Agreement, the terms of the Loan Agreement remain in full force and effect. Bank’s agreement to defer principal payments pursuant to the Deferral Agreement in no way shall constitute a waiver of or forbearance from any existing
defaults under any of the Loan Documents, nor shall it obligate Bank to defer any future payments or waive or forbear from any future defaults under any of the Loan Documents. Nothing in the Deferral Agreement shall constitute a satisfaction of the
Obligations. It is the intention of Bank and Borrower to retain as liable parties all makers of Loan Documents, unless the party is expressly released by Bank in writing. No maker will be released by virtue of the Deferral Agreement.

  

	9.	 Miscellaneous. 

 

	 	a.	 The Deferral Agreement may be executed and delivered in any number of counterparts and all of such counterparts
taken together shall be deemed to constitute one and the same instrument. 

  

	 	b.	 The words “execution,” “signed,” “signature” and words of like import in any Loan
Document, including the Deferral Agreement, shall be deemed to include electronic signatures, including any Electronic Signature as defined in the Electronic Transactions Law (2003 Revision) of the Cayman Islands (the “Cayman Islands Electronic
Signature Law”), or the keeping of records in electronic form, including any Electronic Record, as defined in Cayman Islands Electronic Signature Law, each of which shall be of the same legal effect, validity and enforceability as a manually
executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including, without limitation, any state law based on the Uniform Electronic Transactions Act or the
Cayman Islands Electronic Signature Law; provided, however that sections 8 and 19(3) of the Cayman Islands Electronic Signature Law shall not apply to this Deferral Agreement or the execution or delivery thereof.

 

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 3 of 6

			
	

	  	 Terms and Conditions

Deferral Agreement

  

	c.	 The Deferral Agreement shall be effective as of the Deferral Agreement Effective Date. 

 

	d.	 The Deferral Agreement is a Loan Document and will be construed, interpreted, and applied in accordance with
the laws of the jurisdiction whose laws govern the Loan Agreement (excluding its body of law controlling conflicts of law). Each party to the Deferral Agreement submits to

	 	
the jurisdiction of the same state and federal courts to which it submitted under the Loan Agreement. 

  

	e.	 In the event of any action or proceeding to enforce the Deferral Agreement, Bank shall be entitled to recover
from Borrower its attorneys’ fees and expenses, disbursements and court costs. 

 

  
 [End of Terms and
Conditions – Annex and Consent and Ratification Follow] 

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 4 of 6

			
	

	  	 Consent and Ratification

Deferral Agreement

  

 Additional Borrowers 

Deferral Agreement Effective Date: April 2, 2020 

Borrower: SPRUCE BIOSCIENCES, INC.     

This Annex forms a part of the Deferral Agreement dated as of the date indicated above between Silicon Valley Bank and Borrower, as defined above. Capitalized
terms used but not defined in this Annex shall have the meanings ascribed to them in the Deferral Agreement. 
 Each of the undersigned (collectively, the
“Additional Borrowers”) is a party to the Loan Agreement and hereby agrees to the terms and conditions set forth in the Deferral Agreement. Upon its execution hereof, each Additional Borrower shall be deemed to be a party to the
Deferral Agreement. 
  

									
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	Title	 		 	Title

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 5 of 6

			
	

	  	 Consent and Ratification

Deferral Agreement

  

 This Consent and Ratification should be signed only to the extent that the Deferral Agreement to which it
is attached indicates that it is applicable. Otherwise, this Consent and Ratification is not applicable and void and the following signature blocks should be left blank. 

Each of the undersigned, in its capacity as a guarantor or pledgor of the Obligations under the Loan Agreement and the other Loan Documents, acknowledges
receipt of the Deferral Agreement. Each of the undersigned further: (i) consents to the Deferral Agreement and the transactions and agreements contemplated thereby; (ii) reaffirms and acknowledges its continuing obligations under the
guaranty, pledge agreement or other Loan Document(s) to which it is a party, and that such obligations remain in full force and effect; and (iii) acknowledges that Bank may, but shall be under no obligation to, obtain from the undersigned from
time to time further acknowledgment of its continuing obligation under such agreement(s) or with respect to any extension of the time for payment of the Obligations or of any amendment of the terms thereof, waiver of any default, or forbearance in
the exercise of any remedy afforded Bank by the terms of such Obligations or by law. 
  

									
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	 Title
  
	 		 	Title
	 	 		 	 
	By:	 	 	 		 	By:	 	 
	    	 		 		 		 	
	Name	 		 	Name
		 		 		 		 	
	Title	 		 	Title

  
 © 2020 SVB Financial Group. All
rights reserved. SVB, SVB FINANCIAL GROUP, SILICON VALLEY BANK, MAKE NEXT HAPPEN NOW and the chevron device are trademarks of SVB Financial Group, used under license. Silicon Valley Bank is a member of the FDIC and the Federal Reserve System.
Silicon Valley Bank is the California bank subsidiary of SVB Financial Group (Nasdaq: SIVB). 
  

					
	Rev. March 30, 2020	  	Deferral Agreement	  	Page 6 of 6EX-4.2

 Exhibit 4.2 

SHATTUCK LABS, INC. 

SECOND AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

This Second Amended and Restated Investors’ Rights Agreement (this “Agreement”) is made and entered into as of
June 12, 2020 by and among Shattuck Labs, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an
“Investor,” each of the stockholders listed on Schedule B hereto, each of whom is referred to herein as a “Key Holder,” and any other Person that becomes a party to this
Agreement in accordance with Section 7.14 hereof. 
 RECITALS 

WHEREAS, the Company, certain Investors and certain Key Holders (such Investors and Key Holders collectively, the “Existing
Holders”) have previously entered into that certain Amended and Restated Investors’ Rights Agreement dated as of January 31, 2020 (the “Prior Agreement”); 

WHEREAS, the Existing Holders and the Company desire to induce certain Investors to purchase shares of the Company’s Series B-1 Preferred Stock, par value $0.0001 per share (the “Series B-1 Preferred Stock”) pursuant to that certain Series
B-1 Preferred Stock Purchase Agreement, dated as of June 8, 2020 (the “Purchase Agreement”), by amending and restating the Prior Agreement to provide the Investors and Key Holders
with the rights and privileges as set forth herein; and 
 WHEREAS, the parties executing this Agreement hold a sufficient number of shares
of capital stock of the Company to amend and restate the Prior Agreement. 
 NOW, THEREFORE, in consideration of the foregoing recitals and
the mutual promises hereinafter set forth, the parties hereto hereby agree as follows: 
 1. DEFINITIONS.
For purposes of this Agreement: 
 “Affiliate” means, with respect to any specified Person, such Person’s
principal or any other Person who or which, directly or indirectly, controls, is controlled by, or is under common control with such Person or such Person’s principal, including, without limitation, any general partner, managing member or
partner, officer or director of such Person or such Person’s principal or any venture capital fund, other investment fund or registered investment company now or hereafter existing that is controlled by one or more general partners, managing
members or investment adviser of, or shares the same management company or investment adviser with, such Person or such Person’s principal. For purposes of this definition, the terms “controlling,” “controlled
by,” or “under common control with” will mean the possession, directly or indirectly, of (a) the power to direct or cause the direction of the management and policies of a Person, whether through the
ownership of voting securities, by contract, or otherwise, or (b) the power to elect or appoint at least fifty percent (50%) of the directors, managers, general partners, or persons exercising similar authority with respect to such Person. 

 “Automatic Shelf Registration Statement” will have the meaning given
to that term in SEC Rule 405. 
 “Board” means the board of directors of the Company. 

“Budget” will have the meaning given to that term in Section 2.1.1. 

“business day” means a weekday on which banks are open for general banking business in Austin, Texas. 

“Certificate” means the Company’s Amended and Restated Certificate of Incorporation (as may be amended from time
to time). 
 “CFIUS” means the Committee on Foreign Investment in the United States. 

“Common Stock” means shares of the Company’s common stock, par value $0.0001 per share. 

“Damages” means any loss, damage, or liability (joint or several) to which a party hereto may become subject under the
Securities Act, the Exchange Act, or other federal or state law, insofar as such loss, damage, or liability (or any action in respect thereof) arises out of or is based upon (a) any untrue statement or alleged untrue statement of a material
fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, and any free-writing prospectus and any issuer information (as defined
in Rule 433 of the Securities Act) filed or required to be filed pursuant to Rule 433(d) under the Securities Act or any other document incident to such registration prepared by or on behalf of the Company or used or referred to by the Company;
(b) an omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading; or (c) any violation or alleged violation by the indemnifying party (or any of
its agents or Affiliates) of the Securities Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the Securities Act, the Exchange Act, or any state securities law. 

“Demand Notice” means notice sent by the Company to the Holders that are Major Investors specifying that a demand
registration has been requested as provided in Section 3.1.1. 
 “Derivative Securities” means any securities
or rights convertible into, or exercisable or exchangeable for (in each case, directly or indirectly), Common Stock, including options and warrants. 

“Deemed Liquidation Event” has the meaning set forth for such term in the certificate of incorporation of the Company
most recently filed with the Delaware Secretary of State that contains such a definition, whether or not the holders of outstanding shares of Preferred Stock elect otherwise by written notice sent to the Company as provided in such definition. 

“EcoR1” means EcoR1 Capital Fund, L.P., EcoR1 Capital Fund Qualified, L.P. and EcoR1 Venture Opportunity Fund, L.P.

  
 2 

 “Exchange Act” means the Securities Exchange Act of 1934, as
amended, and the rules and regulations promulgated thereunder. 
 “Excluded Registration” means (a) a
registration relating to the sale of securities to employees of the Company or a subsidiary pursuant to an equity incentive, stock option, stock purchase, or similar plan; (b) a registration relating to an SEC Rule 145 transaction; (c) a
registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or (d) a registration in which the only Common
Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered. 
 “Form
S-1” means such form under the Securities Act as in effect on the date hereof or any successor registration form under the Securities Act subsequently adopted by the SEC. 

“Form S-3” means such form under the Securities Act as in effect
on the date hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

“Free Writing Prospectus” means a free-writing prospectus, as defined in Rule 405 under the Securities Act. 

“GAAP” means generally accepted accounting principles in the United States. 

“Hatteras” means Hatteras Venture Partners VI, LP and Hatteras NC Fund, LP. 

“Holder” means any holder of Registrable Securities who is a party to this Agreement. 

“Immediate Family Member” means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling, mother-in-law, father-in-law,
son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including adoptive relationships, of a natural person referred to herein. 

“Initiating Holders” means, collectively, Holders who properly initiate a registration request under this Agreement.

 “Investor Notice” will have the meaning set forth in Section 4.2. 

“IPO” means the Company’s first underwritten public offering of its Common Stock under the Securities Act. 

“Janus” means Janus Henderson Global Life Sciences Fund, Janus Henderson Capital Funds Plc - Janus Henderson Global
Life Sciences Fund, Janus Henderson Horizon Fund - Biotechnology Fund and Janus Henderson Biotech Innovation Master Fund Limited, and their permitted transferees and other entities for whom Janus Capital Management LLC is the investment adviser.

 “Key Employee” means any executive-level employee (including, division director and vice president-level
positions) as well as any employee who, either alone or in concert with others, develops, invents, programs, or designs any Company Intellectual Property (as defined in the Purchase Agreement). 

  
 3 

 “Key Holder Registrable Securities” means (a) the shares of
Common Stock held by the Key Holders, and (b) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange
for or in replacement of such shares; provided that for purposes of Section 3.1, “Key Holder Registrable Securities” shall only include shares of Common Stock held by a Key Holder who is, or whose Affiliate
is, then providing services to the Company as an employee, consultant, advisor or director. 
 “Major Investor”
means any Investor that, individually or together with such Investor’s Affiliates, holds at least 16,006 shares of Registrable Securities (as adjusted for any stock split, stock dividend, combination, or other recapitalization or
reclassification effected after the date hereof). 
 “New Securities” means, collectively, equity securities of the
Company, whether or not currently authorized, Derivative Securities and any rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or
exercisable for (in each case, directly or indirectly) such equity securities; provided however, that “New Securities” will exclude Exempted Securities (as defined in the Certificate) other than the
securities set forth in clause (x) of the definition of Exempted Securities. 
 “Offer Notice” will have the
meaning set forth in Section 4.1. 
 “Person” means any individual, corporation, partnership, trust, limited
liability company, association or other entity. 
 “PFM” means PFM Healthcare Master Fund, L.P. 

“Preferred Directors” means the Series A Directors and the Series B-1
Directors. 
 “Preferred Stock” means, collectively, shares of the Company’s Series A Preferred Stock, Series B
Preferred Stock and Series B-1 Preferred Stock. 
 “Pro Rata Amount” means,
for each Major Investor, that portion of the New Securities identified in an Offer Notice which equals the proportion that the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the
Preferred Stock and any other Derivative Securities then held, by such Major Investor bears to the total Common Stock of the Company then outstanding (assuming full conversion and/or exercise, as applicable, of all Preferred Stock and other
Derivative Securities). 
 “Redmile” means Redmile Biopharma Investments II, L.P. 

“Registrable Securities” means (a) the Common Stock issuable or issued upon conversion of shares of the Preferred
Stock held by the Investors; (b) the Key Holder Registrable Securities; and (c) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other
distribution with respect to, or in 

  
 4 

 
exchange for or in replacement of, the shares referenced in clauses (a) through (c) above; excluding in all cases, however, any Registrable Securities sold by a Person in a transaction in
which the applicable rights under this Agreement are not assigned pursuant to Section 7.1, and excluding for purposes of Section 3 any shares for which registration rights have terminated pursuant to Section 6.2 of this Agreement.
Notwithstanding the foregoing, the Company will in no event be obligated to register any Preferred Stock of the Company, and Holders of Registrable Securities will not be required to convert their Preferred Stock into Common Stock in order to
exercise the registration rights granted hereunder, until immediately before the closing of the offering to which the registration relates. 

“Registrable Securities then outstanding” means the number of shares determined by adding the number of shares of
outstanding Common Stock that are Registrable Securities and the number of shares of Common Stock issuable (directly or indirectly) pursuant to then exercisable and/or convertible securities that are Registrable Securities. 

“Restricted Securities” means the securities of the Company required to bear the legend set forth in
Section 3.12.2 hereof. 
 “SEC” means the Securities and Exchange Commission. 

“SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities Act. 

“SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act. 

“SEC Rule 405” means Rule 405 promulgated by the SEC under the Securities Act. 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 “Selling Expenses” means all underwriting discounts, selling commissions, and stock transfer taxes applicable to
the sale of Registrable Securities, and fees and disbursements of counsel for any Holder, except for the fees and disbursements of the Selling Holder Counsel borne and paid by the Company as provided in Section 3.6. 

“Selling Holder Counsel” means one counsel for the selling Holders. 

“Series A Director” means any director of the Company that the holders of record of the Series A Preferred Stock are
entitled to elect, exclusively and as a separate class, pursuant to the Certificate. 
 “Series A Preferred Stock”
means shares of the Company’s Series A Preferred Stock, par value $0.0001 per share. 
 “Series B-1 Director” means any director of the Company that the holders of record of the Series B-1 Preferred Stock are entitled to elect, exclusively and as a separate
class, pursuant to the Certificate. 
 “Series B Preferred Stock” means shares of the Company’s Series B
Preferred Stock, par value $0.0001 per share. 

  
 5 

 “Standoff Period” means the period commencing on the date of the
final prospectus relating to an underwritten public offering of the Company’s Common Stock under the Securities Act and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty
(180) days in the event of the Company’s initial public offering or ninety (90) days in the event of any subsequent offering). 

“Stock Sale” means a sale by the Company’s stockholders, in one transaction or series of related transactions, of
equity securities that represent, immediately prior to such transaction or transactions, a majority by voting power of the equity securities of the Company pursuant to an agreement approved by the Board and entered into by the Company. 

“Takeda” means Millennium Pharmaceuticals, Inc. 

2. INFORMATION RIGHTS. 

2.1 Delivery of Financial Statements. 

2.1.1 Information to be Delivered. The Company will deliver the following to each Major Investor, provided that the
Board has not reasonably determined that such Major Investor is a competitor of the Company (provided that none of Redmile, Janus, PFM, EcoR1, and their respective Affiliates shall be considered a competitor of the Company and
provided, further, that Takeda shall be entitled to the information in Section 2.1.1(a), (b), (c), (d), and (e) in any event): 

(a) As soon as practicable, but in any event before the earlier of ninety (90) days after the end of each fiscal year of the Company and
fifteen (15) days of being made available to the Company, (i) a balance sheet as of the end of such year, (ii) statements of income and of cash flows for such year, and (iii) a statement of stockholders’ equity as of the end
of such year, all such financial statements audited and certified by independent public accountants of nationally recognized standing selected by the Company. 

(b) As soon as practicable, but in any event within forty-five (45) days after the end of each
of the first three (3) quarters of each fiscal year of the Company, unaudited statements of income and of cash flows for such fiscal quarter, and an unaudited balance sheet, and a statement of stockholders’ equity as of the end of such
fiscal quarter, all prepared in accordance with GAAP (except that such financial statements may (i) be subject to normal year-end and audit adjustments and (ii) not contain all notes thereto that may
be required in accordance with GAAP). 
 (c) As soon as practicable, but in any event within thirty (30) days before the end of each
fiscal year, a budget for the next fiscal year, approved by the Board and prepared on a monthly basis, including balance sheets, income statements, and statements of cash flow for such months (the “Budget”) and, promptly
after prepared, any other budgets or revised budgets prepared by the Company. 
 (d) Promptly following the end of each quarter of the
fiscal year, an updated capitalization table of the Company if requested by any Major Investor. 

  
 6 

 (e) Such other information relating to the financial condition, business, prospects or
corporate affairs of the Company as any Major Investor may from time to time reasonably request; provided, however, that the Company will not be obligated under this Section 2.1.1(e) to provide information
(i) that the Company reasonably determines in good faith (x) to be a trade secret or confidential information or (y) should be kept confidential for strategic business reasons; or (ii) the disclosure of which would adversely
affect the attorney-client privilege between the Company and its counsel. 
 2.1.2 Consolidation. If, for any period, the Company
has any subsidiary whose accounts are consolidated with those of the Company, then in respect of such period the financial statements delivered pursuant to Section 2.1.1 will be the consolidated and consolidating financial statements of the
Company and all such consolidated subsidiaries. 
 2.1.3 Suspension or Termination. Notwithstanding anything else in this
Section 2.1 to the contrary but subject to Section 6.1, the Company may cease providing the information set forth in this Section 2.1 during the period starting with the date sixty (60) days before the Company’s good-faith
estimate of the date of filing of a registration statement if it reasonably concludes it must do so to comply with the SEC rules applicable to such registration statement and related offering; provided that the Company’s covenants
under this Section 2.1 will be reinstated at such time as the Company is no longer actively employing its reasonable efforts to cause such registration statement to become effective. 

2.2 Inspection. The Company will permit each Major Investor (provided that the Board has not
reasonably determined that such Major Investor is a competitor of the Company; provided that none of Redmile, Janus, PFM, EcoR1 and their respective Affiliates shall be considered a competitor of the Company; and
provided, further, that Takeda shall also be permitted even if the Board has determined that Takeda is a competitor), at such Major Investor’s expense, to visit and inspect the Company’s properties; examine its
books of account and records; and discuss the Company’s affairs, finances, and accounts with its officers, during normal business hours of the Company as may be reasonably requested by the Major Investor; provided,
however, that the Company will not be obligated pursuant to this Subsection 2.2 to provide access to any information that it reasonably and in good faith considers (a) to be a trade secret or confidential information or
(b) should be kept confidential for strategic business reasons or the disclosure of which would adversely affect the attorney-client privilege between the Company and its counsel. 

2.3 Confidentiality. Each Investor agrees that such Investor will keep confidential and will not disclose,
divulge, or use for any purpose (other than to monitor its investment in the Company) any confidential information obtained from the Company pursuant to the terms of this Agreement unless such confidential information (a) is known or becomes
known to the public in general (other than as a result of a breach of this Section 2.3 by such Investor), (b) is or has been independently developed or conceived by the Investor without access to, reference to, or reliance upon the
Company’s confidential information as demonstrated by competent and contemporaneous written records, or (c) is or has been made known or disclosed to the Investor by a third party rightfully in possession of such confidential information
and without a breach of any obligation of confidentiality such third party may have to the Company; provided, however, that an Investor may disclose confidential information to the following persons so long as such
persons are subject to written obligations of confidentiality no less restrictive than this Section 2: (i) to its attorneys, accountants, consultants, and other professionals to the extent necessary to

  
 7 

 
obtain their services in connection with monitoring its investment in the Company; (ii) to any prospective purchaser of any Registrable Securities from such Investor, if such prospective
purchaser agrees to be bound by the provisions of this Section 2.3; (iii) to any existing or prospective Affiliate, partner, member, stockholder, or wholly owned subsidiary of such Investor to the extent such disclosure is necessary for the
ordinary course of business; or (iv) as may otherwise be required by law if the Investor promptly notifies the Company of such disclosure and takes reasonable steps to minimize the extent of any such required disclosure. 

3. REGISTRATION RIGHTS. 

3.1 Demand Registration. 

3.1.1 Form S-1 Demand. If at any time after the earlier of (a) five (5) years after
the date of this Agreement or (b) one hundred eighty (180) days after the effective date of the registration statement for the IPO, the Company receives a request from either (x) Holders who are Major Investors and hold at least a
majority of the Registrable Securities then outstanding and held by Major Investors or (y) Holders who are Major Investors and hold at least seventy percent (70%) of the Registrable Securities then outstanding that are Registrable Securities
under clauses (a) and (c) (solely to the extent derived from Registrable Securities under clause (a)) of the definition thereof, that the Company file a Form S-1 registration statement with respect to any
Registrable Securities then outstanding (and the Registrable Securities subject to such request have an anticipated aggregate offering price, net of Selling Expenses, of at least $25,000,000), then the Company will (i) within ten
(10) business days after the date such request is given, give a Demand Notice to all Holders that are Major Investors other than the Initiating Holders; and (ii) use commercially reasonable efforts to as soon as practicable, and in any
event within ninety (90) days after the date such request is given by the Initiating Holders, file a Form S-1 registration statement under the Securities Act covering all Registrable Securities that the
Initiating Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders that are Major Investors, as specified by notice given by each such Holder to the Company
within twenty (20) days after the date the Demand Notice is given, and in each case, subject to the limitations of Section 3.1.3 and Section 3.3. 

3.1.2 Form S-3 Demand. If at any time when it is eligible to use a Form S-3 registration statement, the Company receives a request either (x) Holders who are Major Investors and hold at least a majority of the Registrable Securities then outstanding and held by Major Investors or
(y) Holders who are Major Investors and hold at least seventy percent (70%) of the Registrable Securities then outstanding that are Registrable Securities under clauses (a) and (c) (solely to the extent derived from Registrable Securities
under clause (a)) of the definition thereof, that the Company file a Form S-3 registration statement with respect to outstanding Registrable Securities of such Holders having an anticipated aggregate offering
price, net of Selling Expenses, of at least $5,000,000, then the Company will (a) within ten (10) days after the date such request is given, give a Demand Notice to all Holders that are Major Investors other than the Initiating Holders;
and (b) use commercially reasonable efforts to as soon as practicable, and in any event within forty-five (45) days after the date such request is given by the Initiating Holders, file a Form S-3
registration statement under the Securities Act covering all Registrable Securities requested to be included in such registration by any other Holders that are Major Investors, as specified by notice given by each such Holder to the Company within
twenty (20) days of the date the Demand Notice is given, and in each case, subject to the limitations of Section 3.1.3 and Section 3.3. 

  
 8 

 3.1.3 Delay. Notwithstanding the foregoing obligations, if the Company furnishes to
Holders requesting a registration pursuant to this Section 3.1 a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Board it would be materially detrimental to the Company and its
stockholders for such registration statement to either become effective or remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would (a) materially interfere with a
significant acquisition, corporate reorganization, or other similar transaction involving the Company; (b) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential; or
(c) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the Company will have the right to defer taking action with respect to such filing, and any time periods with respect to filing or
effectiveness thereof will be tolled correspondingly, for a period of not more than ninety (90) days after the request of the Initiating Holders is given; provided, however, that (i) the Company may not
invoke this right more than once in any twelve (12) month period and (ii) the Company will not register any securities for its own account or that of any other stockholder during such ninety (90) day period other than an Excluded
Registration. 
 3.1.4 Limitations. The Company will not be obligated to effect, or to take any action to effect, any registration
pursuant to Section 3.1.1: (a) during the period that is sixty (60) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is one hundred eighty (180) days after the effective date of, a
Company-initiated registration, provided, that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; (b) after the Company has effected two
(2) registrations pursuant to Section 3.1.1; or (c) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a
request made pursuant to Section 3.1.2. The Company will not be obligated to effect, or to take any action to effect, any registration pursuant to Section 3.1.2: (i) during the period that is thirty (30) days before the Company’s
good faith estimate of the date of filing of, and ending on a date that is ninety (90) days after the effective date of, a Company-initiated registration, provided, that the Company is actively employing in good faith commercially
reasonable efforts to cause such registration statement to become effective; or (ii) if the Company has effected two (2) registrations pursuant to Section 3.1.2 within the twelve (12) month period immediately preceding the date
of such request. A registration will not be counted as “effected” for purposes of this Section 3.1.4 until such time as the applicable registration statement has been declared effective by the SEC, unless the Initiating Holders
withdraw their request for such registration, elect not to pay the registration expenses therefor, and forfeit their right to one registration on Form S-1 or S-3, as
applicable, pursuant to Section 3.6, in which case such withdrawn registration statement will be counted as “effected” for purposes of this Section 3.1.4.  

3.2 Company Registration. If the Company proposes to register (including, for this purpose, a registration
effected by the Company for stockholders other than the Holders that are Major Investors) any of its Common Stock under the Securities Act in connection with the public offering of such securities solely for cash (other than in an Excluded
Registration), the Company will, at such time, promptly give each Holder that is a Major Investor notice of such 

  
 9 

 
registration. Upon the request of each Holder that is a Major Investor given within twenty (20) days after such notice is given by the Company, the Company will, subject to the provisions of
Section 3.3, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such registration. The Company will have the right to terminate or withdraw any registration initiated by it under this
Section 3.2 before the effective date of such registration, whether or not any Holder has elected to include Registrable Securities in such registration. The expenses (other than Selling Expenses) of such withdrawn registration will be borne by
the Company in accordance with Section 3.6. 
 3.3 Underwriting Requirements. 

3.3.1 Inclusion. If, pursuant to Section 3.1, the Initiating Holders intend to distribute the Registrable Securities covered by
their request by means of an underwriting, they will so advise the Company as a part of their request made pursuant to Section 3.1, and the Company will include such information in the Demand Notice. The underwriter(s) will be selected by the
Company, subject only to the reasonable approval of the holders of at least a majority of Registrable Securities held by the Initiating Holders. In such event, the right of any Holder to include such Holder’s Registrable Securities in such
registration will be conditioned upon such Holder’s participation in such underwriting. All Holders proposing to distribute their securities through such underwriting will (together with the Company as provided in Section 3.4(e)) enter
into an underwriting agreement in customary form with the underwriter(s) selected for such underwriting. Notwithstanding any other provision of this Section 3.3, if the managing underwriter(s) advise(s) the Initiating Holders in writing that
marketing factors require a limitation on the number of shares to be underwritten, then the Initiating Holders will so advise all Holders of Registrable Securities that otherwise would be underwritten pursuant hereto, and the number of Registrable
Securities that may be included in the underwriting will be allocated among such Holders of Registrable Securities, including the Initiating Holders, in proportion (as nearly as practicable) to the number of Registrable Securities owned or held by
each Holder or in such other proportion as will mutually be agreed to by all such selling Holders. Notwithstanding the foregoing, in no event will (a) the number of Registrable Securities included in the offering be reduced unless all other
securities (other than securities to be sold by the Company) are first entirely excluded from the offering, (b) the number of Registrable Securities included in the offering be reduced below thirty percent (30%) of the total number of
securities included in such offering, unless such offering is the IPO, in which case the selling Holders may be excluded further if the underwriters make the determination described above and no other stockholder’s securities are included in
such offering or (c) notwithstanding clause (b) above, any Registrable Securities which are not Key Holder Registrable Securities be excluded from such underwriting unless all Key Holder Registrable Securities are first excluded from such
offering. For purposes of the provision in this Section 3.3.2 concerning apportionment, for any selling Holder that is a partnership, limited liability company, or corporation, the partners, members, retired partners, retired members,
stockholders, and Affiliates of such Holder, or the estates and Immediate Family Members of any such partners, retired partners, members, and retired members and any trusts for the benefit of any of the foregoing Persons, will be deemed to be a
single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” will be based upon the aggregate number of Registrable Securities owned or held by all Persons included in such “selling Holder,”
as defined in this sentence. To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. 

  
 10 

 3.3.2 Underwriter Cutback. In connection with any offering involving an underwriting
of shares of the Company’s capital stock pursuant to Section 3.2, the Company will not be required to include any of the Holders’ Registrable Securities in such underwriting unless the Holders accept the terms of the underwriting as
agreed upon between the Company and its underwriters. If the total number of securities, including Registrable Securities, requested by stockholders to be included in such offering exceeds the number of securities to be sold (other than by the
Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company will be required to include in the offering only that number of such securities, including Registrable
Securities, which the underwriters and the Company in their sole discretion determine will not jeopardize the success of the offering. If the underwriters determine that less than all of the Registrable Securities requested to be registered can be
included in such offering, then the Registrable Securities that are included in such offering will be allocated among the selling Holders in proportion (as nearly as practicable to) the number of Registrable Securities owned or held by each selling
Holder or in such other proportions as will mutually be agreed to by all such selling Holders. To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated
to any Holder to the nearest one hundred (100) shares. Notwithstanding the foregoing, in no event will (a) the number of Registrable Securities included in the offering be reduced unless all other securities (other than securities to be
sold by the Company) are first entirely excluded from the offering, (b) the number of Registrable Securities included in the offering be reduced below thirty percent (30%) of the total number of securities included in such offering, unless such
offering is the IPO, in which case the selling Holders may be excluded further if the underwriters make the determination described above and no other stockholder’s securities are included in such offering or (c) notwithstanding clause
(b) above, any Registrable Securities which are not Key Holder Registrable Securities be excluded from such underwriting unless all Key Holder Registrable Securities are first excluded from such offering. For purposes of the provision in this
Section 3.3.2 concerning apportionment, for any selling Holder that is a partnership, limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, or the
estates and Immediate Family Members of any such partners, retired partners, members, and retired members and any trusts for the benefit of any of the foregoing Persons, will be deemed to be a single “selling Holder,” and any pro rata
reduction with respect to such “selling Holder” will be based upon the aggregate number of Registrable Securities owned or held by all Persons included in such “selling Holder,” as defined in this sentence. 

3.3.3 Registration Not Effected. For purposes of Section 3.1, a registration will not be counted as “effected” if, as a
result of an exercise of the underwriter’s cutback provisions in Section 3.3.1, fewer than fifty percent (50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are
actually included. 
 3.4 Obligations of the Company. Whenever required under this Section 3 to effect the
registration of any Registrable Securities, the Company will, as expeditiously as reasonably possible: 

  
 11 

 (a) prepare and file with the SEC a registration statement with respect to such Registrable
Securities and use its commercially reasonable efforts to cause such registration statement to become effective as promptly as practicable, and, upon the request of the Holders of at least a majority of the Registrable Securities registered
thereunder, keep such registration statement effective for a period of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in the registration statement has been completed; provided,
however, that (i) such one hundred twenty (120) day period will be extended for a period of time equal to the period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of the
Company, from selling any securities included in such registration, and (ii) in the case of any registration of Registrable Securities on Form S-3 that are intended to be offered on a continuous or
delayed basis, subject to compliance with applicable SEC rules, such one hundred twenty (120) day period will be extended for up to sixty (60) days, if necessary, to keep the registration statement effective until all such Registrable
Securities are sold; 
 (b) prepare and file with the SEC such amendments and supplements to such registration statement, the prospectus
and, if required, any Free Writing Prospectus used in connection with such registration statement as may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement; 

(c) furnish to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus and any Free Writing
Prospectus, as required by the Securities Act, and such other documents as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities; 

(d) use its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or blue-sky laws of such jurisdictions as will be reasonably requested by the selling Holders; provided that the Company will not be required to qualify to do business or to file a
general consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

(e) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary form, with the underwriter(s) of such offering; 
 (f) use its reasonable efforts to cause all such Registrable Securities
covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then listed; 

(g) provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number
for all such Registrable Securities, in each case not later than the effective date of such registration; 
 (h) promptly make available
for inspection by the selling Holders, any managing underwriter(s) participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling
Holders, all financial and other records, pertinent corporate documents, and properties of 

  
 12 

 
the Company, and cause the Company’s officers, directors, employees, and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney,
accountant, or agent, in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; 

(i) notify each selling Holder, promptly after the Company receives notice thereof, of the time when such registration statement has been
declared effective or a supplement to any prospectus or Free Writing Prospectus forming a part of such registration statement has been filed; 

(j) after such registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or
supplement such registration statement or prospectus or Free Writing Prospectus; 
 (k) use its commercially reasonable efforts to obtain
for the underwriters one or more “cold comfort” letters, dated the effective date of the related registration statement (and, if such registration includes an underwritten public offering, dated the date of the closing under the
underwriting agreement), signed by the Company’s independent public accountants in customary form and covering such matters of the type customarily covered by “cold comfort” letters; 

(l) use its commercially reasonable efforts to obtain for the underwriters on the date such securities are delivered to the underwriters for
sale pursuant to such registration a legal opinion of the Company’s outside counsel with respect to the registration statement, each amendment and supplement thereto, the prospectus included therein (including the preliminary prospectus) and
such other documents relating thereto in customary form and covering such matters of the type customarily covered by legal opinions of such nature; 

(m) to the extent the Company is a well-known seasoned issuer (as defined in SEC Rule 405) at the time any request for registration is
submitted to the Company in accordance with Section 3.1, if so requested, file an Automatic Shelf Registration Statement to effect such registration; and 

(n) if at any time when the Company is required to re-evaluate its well-known seasoned issuer status
for purposes of an outstanding Automatic Shelf Registration Statement used to effect a request for registration in accordance with Section 3.1.2 the Company determines that it is not a well-known seasoned issuer and (i) the registration
statement is required to be kept effective in accordance with this Agreement and (ii) the registration rights of the applicable Holders have not terminated, use commercially reasonable efforts to promptly amend the registration statement on a
form the Company is then eligible to use or file a new registration statement on such form, and keep such registration statement effective in accordance with the requirements otherwise applicable under this Agreement. 

3.5 Furnish Information. It will be a condition precedent to the obligations of the Company to take any action
pursuant to this Section 3 with respect to the Registrable Securities of any selling Holder that such Holder will furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of
disposition of such securities as is reasonably required to effect the registration of such Holder’s Registrable Securities. 

  
 13 

 3.6 Expenses of Registration. All expenses (other than Selling
Expenses) incurred in connection with registrations, filings, or qualifications pursuant to Section 3, including all registration, filing, and qualification fees; printers’ and accounting fees; fees and disbursements of counsel for the
Company; and the reasonable fees and disbursements of one Selling Holder Counsel, not to exceed $30,000, will be borne and paid by the Company; provided, however, that (a) the Company will not be required to
pay for any expenses of any registration proceeding begun pursuant to Section 3.1 if the registration request is subsequently withdrawn at the request of the Holders of at least a majority of the Registrable Securities to be registered (in
which case all selling Holders will bear such expenses pro rata based upon the number of Registrable Securities that were to be included in the withdrawn registration), unless the Holders that are Major Investors who hold at least a majority of the
Registrable Securities held by Major Investors agree to forfeit their right to one registration pursuant to Section 3.1.1 or Section 3.1.2, as the case may be, and (b) if, at the time of such withdrawal, the Holders will have learned
of a material adverse change in the condition, business, or prospects of the Company not known to the Holders at the time of their request and have withdrawn the request with reasonable promptness after learning of such information, then the Holders
will not be required to pay any of such expenses and will not forfeit their right to one registration pursuant to Section 3.1.1 or Section 3.1.2. All Selling Expenses relating to Registrable Securities registered pursuant to this
Section 3 will be borne and paid by the Holders pro rata on the basis of the number of Registrable Securities registered on their behalf. 

3.7 Delay of Registration. No Holder will have any right to obtain or seek an injunction restraining or otherwise
delaying any registration pursuant to this Agreement as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 3. 

3.8 Indemnification. If any Registrable Securities are included in a registration statement under this
Section 3: 
 3.8.1 Company Indemnification. To the extent permitted by law, the Company will indemnify and hold harmless each
selling Holder, and the partners, members, officers, directors, and stockholders of each such Holder; legal counsel, accountants, and investment advisers for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder;
and each Person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person, or other
aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are incurred; provided,
however, that the indemnity agreement contained in this Section 3.8.1 will not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent of the Company, which
consent will not be unreasonably withheld, conditioned, or delayed nor will the Company be liable for any Damages to the extent that they arise out of or are based upon actions or omissions made in reliance upon and in conformity with written
information furnished by or on behalf of any such Holder, underwriter, controlling Person, or other aforementioned Person expressly for use in connection with such registration. 

  
 14 

 3.8.2 Selling Holder Indemnification. To the extent permitted by law, each selling
Holder, severally and not jointly, will indemnify and hold harmless the Company, and each of its directors, each of its officers who has signed the registration statement, each Person (if any), who controls the Company within the meaning of the
Securities Act, legal counsel and accountants for the Company, any underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter or other
Holder, against any Damages, in each case only to the extent that such Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of such selling Holder
expressly for use in connection with such registration; and each such selling Holder will pay to the Company and each other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating or defending
any claim or proceeding from which Damages may result, as such expenses are incurred; provided, however, that (a) the indemnity agreement contained in this Section 3.8.2 will not apply to amounts paid in
settlement of any such claim or proceeding if such settlement is effected without the consent of the Holder, which consent will not be unreasonably withheld, conditioned or delayed, and (b) that in no event will the aggregate amounts payable by
any Holder by way of indemnity or contribution under Sections 3.8.2 and 3.8.4 exceed the proceeds from the offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of fraud or willful misconduct by such
Holder. 
 3.8.3 Procedures. Promptly after receipt by an indemnified party under this Section 3.8 of notice of the
commencement of any action (including any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this
Section 3.8, give the indemnifying party notice of the commencement thereof. The indemnifying party will have the right to participate in such action and, to the extent the indemnifying party so desires, participate jointly with any other
indemnifying party to which notice has been given, and to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party (together with all other
indemnified parties that may be represented without conflict by one counsel) will have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the
counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such action. The failure to give notice to the
indemnifying party within a reasonable time of the commencement of any such action will relieve such indemnifying party of any liability to the indemnified party under this Section 3.8, solely to the extent that such failure prejudices the
indemnifying party’s ability to defend such action. 
 3.8.4 Contribution. To provide for just and equitable contribution to
joint liability under the Securities Act in any case in which either (a) any party otherwise entitled to indemnification hereunder makes a claim for indemnification pursuant to this Section 3.8 but it is judicially determined (by the entry
of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case, notwithstanding the fact that this
Section 3.8 provides for indemnification in such case, or (b) contribution under the Securities Act may be required on the part of any party hereto for which indemnification is provided under this Section 3.8, then, and in each such
case, such parties will contribute to the aggregate losses, claims, 

  
 15 

 
damages, liabilities, or expenses to which they may be subject (after contribution from others) in such proportion as is appropriate to reflect the relative fault of each of the indemnifying
party and the indemnified party in connection with the statements, omissions, or other actions that resulted in such loss, claim, damage, liability, or expense, as well as to reflect any other relevant equitable considerations. The relative fault of
the indemnifying party and of the indemnified party will be determined by reference to, among other things, whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to
information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission; provided,
however, that: 
 (i) in any such case, (A) no Holder will be required to contribute any amount in excess of the
public offering price of all such Registrable Securities offered and sold by such Holder pursuant to such registration statement, and (B) no Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and 
 (ii) in no
event will a Holder’s liability pursuant to this Section 3.8.4, when combined with the amounts paid or payable by such Holder pursuant to Section 3.8.2, exceed the proceeds from the offering received by such Holder (net of any Selling
Expenses paid by such Holder), except in the case of fraud or willful misconduct by such Holder. 
 3.8.5 Underwriting Agreement
Controls. Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the
foregoing provisions, the provisions in the underwriting agreement will control. 
 3.8.6 Survival. Unless otherwise superseded by
an underwriting agreement entered into in connection with the underwritten public offering, the obligations of the Company and Holders under this Section 3.8 will survive the completion of any offering of Registrable Securities in a
registration under this Section 3, and otherwise will survive the termination of this Agreement. 
 3.9 Reports under the
Exchange Act. With a view to making available to the Holders the benefits of SEC Rule 144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without
registration or pursuant to a registration on Form S-3, the Company will: 
 (a) use commercially
reasonable efforts to make and keep available adequate current public information, as those terms are understood and defined in SEC Rule 144, at all times after the effective date of the registration statement filed by the Company for the IPO; 

(b) use commercially reasonable efforts to file with the SEC in a timely manner all reports and other documents required of the Company under
the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

  
 16 

 (c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith
upon request (i) to the extent accurate, a written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the registration statement
filed by the Company for the IPO), the Securities Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after the Company so qualifies); and (ii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any such
securities without registration (at any time after the Company has become subject to the reporting requirements under the Exchange Act) or pursuant to Form S-3 (at any time after the Company so qualifies to
use such form). 
 3.10 Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company will not, without the prior written consent of the Holders that are Major Investors who hold at least sixty five percent (65%) of the Registrable Securities then outstanding, enter into any agreement with any holder or
prospective holder of any securities of the Company that would allow such holder or prospective holder to include such securities in any registration if such agreement (a) would allow such holder or prospective holder to include a portion of
its securities in any “piggyback” registration if such inclusion could reduce the number of Registrable Securities that selling Holders could be entitled to include in such registration under Sections 3.2 and 3.3.2 hereof or (b) would
allow such holder or prospective holder to initiate a demand for registration of any of its securities at a time earlier than the Holders of Registrable Securities can demand registration under Section 3.1 hereof. 

3.11 “Market Stand-off”
Agreement. Each Holder hereby agrees that, during the Standoff Period, such Holder will not, without the prior written consent of the Company or the managing underwriter, 

(a) lend, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any
option, right, or warrant to purchase or otherwise transfer or dispose of, directly or indirectly, any shares of Common Stock, or any securities convertible into or exercisable or exchangeable (directly or indirectly) for Common Stock, held
immediately before the effective date of the registration statement for such offering; or 
 (b) enter into any swap or other
arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of such securities, whether any such transaction described in clause (a) above is to be settled by delivery of Common Stock or other
securities, in cash, or otherwise. 
 The foregoing provisions of this Section 3.11 will not apply to the sale of any shares to an underwriter pursuant
to an underwriting agreement, and will be applicable to the Holders only if all officers, directors, and stockholders individually owning more than five percent (5%) of the Company’s outstanding Common Stock (after giving effect to conversion
into Common Stock of all outstanding Preferred Stock) are similarly bound. For purposes of this Section 3.11, the term “Company” will include any wholly-owned subsidiary of the Company into which the Company merges or consolidates. In
order to enforce the foregoing covenant, the Company will have the right to place restrictive legends on the certificates representing the shares subject to this Section 

  
 17 

 
3.11 and to impose stop transfer instructions with respect to such shares until the end of such period. The underwriters in connection with such registration are intended third-party beneficiaries of this Section 3.11 and will have the right, power, and authority to enforce the provisions hereof as though they were a party hereto. Each Holder further agrees to execute such
agreements as may be reasonably requested by the underwriters in connection with such registration that are consistent with this Section 3.11 or that are necessary to give further effect thereto. The foregoing provisions of this
Section 3.11 shall not apply to transactions or announcements relating to securities acquired (A) in the IPO or (B) in open market transactions from and after the IPO. Any discretionary waiver or termination of the restrictions of any
or all of such agreements by the Company or the underwriters will apply pro rata to all Company stockholders that are subject to such agreements, based on the number of shares subject to such agreements. 

3.12 Restrictions on Transfer. 

3.12.1 Agreement Binding. The Preferred Stock and the Registrable Securities will not be sold, pledged, or otherwise transferred, and
the Company will not recognize and will issue stop-transfer instructions to its transfer agent with respect to any such sale, pledge, or transfer, except upon the conditions specified in this Agreement, which conditions are intended to ensure
compliance with the provisions of the Securities Act. A transferring Holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by such Holder to agree to take and hold such securities
subject to the provisions and upon the conditions specified in this Agreement. Notwithstanding the foregoing, the Company shall not require any transferee of shares pursuant to an effective registration statement or, following the IPO, SEC Rule 144
to be bound by the terms of this Agreement. 
 3.12.2 Legends. Each certificate or instrument representing (a) the Preferred
Stock, (b) the Registrable Securities, and (c) any other securities issued in respect of the securities referenced in clauses (a) and (b), upon any stock split, stock dividend, recapitalization, merger, consolidation, or similar
event, will (unless otherwise permitted by the provisions of Section 3.12.3) be stamped or otherwise imprinted with a legend substantially in the following form: 

THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND HAVE BEEN ACQUIRED FOR
INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM REASONABLY SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. 
 THE SHARES REPRESENTED BY THIS
CERTIFICATE MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY. 

  
 18 

 The Holders consent to the Company making a notation in its records and giving instructions to any transfer
agent of the Restricted Securities in order to implement the restrictions on transfer set forth in this Section 3.12. 
 3.12.3
Procedure. The holder of each certificate representing Restricted Securities, by acceptance thereof, agrees to comply in all respects with the provisions of this Section 3. Before any proposed sale, pledge, or transfer of any Restricted
Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transaction or, following the IPO, the transfer is made pursuant to SEC Rule 144, the Holder thereof will give notice to the Company of
such Holder’s intention to effect such sale, pledge, or transfer. Each such notice will describe the manner and circumstances of the proposed sale, pledge, or transfer in sufficient detail and, if reasonably requested by the Company, will be
accompanied at such Holder’s expense by either (a) a written opinion of legal counsel who will, and whose legal opinion will, be reasonably satisfactory to the Company, addressed to the Company, to the effect that the proposed transaction
may be effected without registration under the Securities Act; (b) a “no action” letter from the SEC to the effect that the proposed sale, pledge, or transfer of such Restricted Securities without registration will not result in a
recommendation by the staff of the SEC that action be taken with respect thereto; or (c) any other evidence reasonably satisfactory to counsel to the Company to the effect that the proposed sale, pledge, or transfer of the Restricted Securities
may be effected without registration under the Securities Act, whereupon the Holder of such Restricted Securities will be entitled to sell, pledge, or transfer such Restricted Securities in accordance with the terms of the notice given by the Holder
to the Company. The Company will not require such a legal opinion or “no action” letter (i) in any transaction in compliance with SEC Rule 144 or (ii) in any transaction in which such Holder transfers Restricted Securities to an
Affiliate of such Holder; provided that other than in connection with a transaction in compliance with SEC Rule 144 following the IPO, each transferee agrees in writing to be subject to the terms of this Section 3.12. Each
certificate or instrument evidencing the Restricted Securities transferred as above provided will bear, except if such transfer is made pursuant to SEC Rule 144 or pursuant to an effective registration statement, the appropriate restrictive
legend set forth in Section 3.12.2, except that such certificate will not bear such restrictive legend if, in the opinion of counsel for such Holder and the Company, such legend is not required in order to establish compliance with any
provisions of the Securities Act. Until the IPO, no Holder will transfer any Restricted Securities to any person or entity that is determined to be a competitor of the Company, in the good faith judgment of the Board. 

4. RIGHTS TO FUTURE STOCK ISSUANCES. Subject to the terms and conditions of this Section 4 and applicable
securities laws, if the Company proposes to sell any New Securities, the Company will offer to sell a portion of New Securities to each Major Investor as described in this Section 4. A Major Investor will be entitled to apportion the right of
first refusal hereby granted to it among itself and its Affiliates in such proportions as it deems appropriate. The right of first refusal in this Section 4 will not be applicable with respect to any Major Investor, if at the time of such
subsequent securities issuance, the Major Investor is not an “accredited investor,” as that term is then defined in Rule 501(a) under the Securities Act. 

4.1 Company Notice. The Company will give notice (the “Offer Notice”) to each Major
Investor, stating (a) its bona fide intention to sell such New Securities, (b) the number of such New Securities to be sold and (c) the price and terms, if any, upon which it proposes to sell such New Securities. 

  
 19 

 4.2 Investor Right. By written notice (the “Investor
Notice”) to the Company within twenty (20) days after the Offer Notice is given, each Major Investor may elect to purchase or otherwise acquire, at the price and on the terms specified in the Offer Notice, up to such Major
Investor’s Pro Rata Amount. A Major Investor’s election may be conditioned on the consummation of the transaction described in the Offer Notice. The closing of any sale pursuant to this Section 4.2 will occur on the earlier of one
hundred and twenty (120) days after the date that the Offer Notice is given and the date of initial sale of New Securities pursuant to Section 4.3. 

4.3 Sale of Securities. If all New Securities referred to in the Offer Notice are not elected to be purchased or
acquired as provided in Section 4.2, the Company may, during the ninety (90) day period following the expiration of the periods provided in Section 4.2, offer and sell the remaining unsubscribed portion of such New Securities to any
Person or Persons at a price not less than, and upon terms no more favorable to the offeree than, those specified in the Offer Notice. If the Company does not enter into an agreement for the sale of the New Securities within such period, or if such
agreement is not consummated within thirty (30) days of the execution thereof, the right provided hereunder will be deemed to be revived and such New Securities will not be offered unless first reoffered to the Major Investors in accordance
with this Section 4. 
 4.4 Alternate Procedure. Notwithstanding any provision hereof to the contrary, in
lieu of complying with the provisions of Sections 4.1 and 4.2, the Company may elect to give notice to the Major Investors within thirty (30) days after the issuance of New Securities. Such notice will describe the type, price, and terms of the
New Securities, and the identities of the Persons to whom the New Securities were sold. Each Major Investor will have twenty (20) days after the date the Company’s notice is given to elect, by giving notice to the Company, to purchase up
to the number of New Securities that such Major Investor would otherwise have the right to purchase pursuant to Section 4.2 above had the Company complied with the provisions of Sections 4.1 and 4.2 in connection with the issuance of such New
Securities under the terms and conditions set forth in the Company’s notice pursuant to this Section 4.4. The closing of such sale will occur within sixty (60) days of the date notice is given to the Major Investors. 

5. ADDITIONAL COVENANTS. 

5.1 Insurance. The Company shall use its commercially reasonable efforts to maintain the Directors and Officers
liability insurance policies and term “key-person” insurance policies on Josiah Hornblower, Taylor Schreiber and Arundathy Nirmalini Pandite that are in place immediately prior to the Closing (as
defined in the Purchase Agreement), or substantially similar policies, each in an amount and on terms and conditions that are commercially reasonable and satisfactory to the Board, until such time as the Board determines that such insurance should
be discontinued. Notwithstanding any other provision of this Section 5.1, (i) each Directors and Officers liability insurance policy shall be written by an insurer with a rating of “A” or better from A.M. Best and each such policy
shall include a separate “side A” coverage or a bankruptcy protective provision and (ii) the Company shall not cease to maintain a Directors and Officers liability insurance policy in an amount of at least $5,000,000, in each case
unless approved by the Board. Each key-person policy will name the Company as loss payee, and will not be cancelable by the Company without prior approval by the Board. 

  
 20 

 5.2 Employee Agreements. The Company will cause (i) each
person now or hereafter employed by it or by any subsidiary (or engaged by the Company or any subsidiary as a consultant/independent contractor) with access to confidential information and/or trade secrets to enter into a nondisclosure and
proprietary rights assignment agreement; and (ii) each Key Employee to enter into a one (1) year nonsolicitation agreement, substantially in the form approved by the Board. 

5.3 Matters Requiring Preferred Director Approval. So long as the holders of Preferred Stock are entitled to elect
a Preferred Director, the Company hereby covenants and agrees with each of the Investors that it shall not, without approval of the Board, which approval must include the affirmative vote of at least one of the Preferred Directors (to the extent
then in office): 
 (a) make, or permit any subsidiary to make, any loan or advance to, or own any stock or other securities of, any
subsidiary or other corporation, partnership, or other entity unless it is wholly owned by the Company; 
 (b) make, or permit any
subsidiary to make, any loan or advance to any Person, including, without limitation, any employee or director of the Company or any subsidiary, except advances and similar expenditures in the ordinary course of business or under the terms of an
employee stock or option plan approved by the Board; 
 (c) guarantee, directly or indirectly, or permit any subsidiary to guarantee,
directly or indirectly, any indebtedness except for trade accounts of the Company or any subsidiary arising in the ordinary course of business; 

(d) make any investment inconsistent with any investment policy approved by the Board; 

(e) incur any aggregate indebtedness in excess of $5,000,000 that is not already included in a budget approved by the Board, other than trade
credit incurred in the ordinary course of business; 
 (f) otherwise enter into or be a party to any transaction with any director,
officer, or employee of the Company or any “associate” (as defined in Rule 12b-2 promulgated under the Exchange Act) of any such Person, except for transactions made in the ordinary course of
business and pursuant to reasonable requirements of the Company’s business and upon fair and reasonable terms that are approved by a majority of the Board; or 

(g) cease to operate in the biotechnology or pharmaceutical industry, or operate in any industry other than the biotechnology or
pharmaceutical industry. 
 5.4 Board Matters. Unless otherwise determined by the vote of a majority of the
directors then in office, the Board will meet at least quarterly in accordance with an agreed-upon schedule. The Company will reimburse the nonemployee directors for all reasonable
out-of-pocket travel expenses incurred (consistent with the Company’s travel policy) in connection with attending meetings of the Board. 

  
 21 

 5.5 Successor Indemnification. If the Company or any of its
successors or assignees consolidates with or merges into any other Person and is not the continuing or surviving corporation or entity of such consolidation or merger, then to the extent necessary, proper provision will be made so that the
successors and assignees of the Company assume the obligations of the Company with respect to indemnification of members of the Board as in effect immediately before such transaction, whether such obligations are contained in the Company’s
Bylaws, the Certificate of Incorporation, or elsewhere, as the case may be. 
 5.6 Right to Conduct Activities.
The Company hereby agrees and acknowledges that Takeda, Redmile, Janus, PFM, EcoR1 and Hatteras (together with their respective Affiliates, the “VC Funds”) reviews the business plans and related proprietary information
of many enterprises, some of which may compete directly or indirectly with the Company’s business (as currently conducted or as currently propose to be conducted). The Company hereby agrees that, to the extent permitted under applicable
law, the VC Funds will not be liable to the Company for any claim arising out of, or based upon, (i) the investment by the VC Funds in any entity competitive with the Company, or (ii) actions taken by any partner, officer, employee or
other representative of the VC Funds to assist any such competitive company, whether or not such action was taken as a member of the board of directors of such competitive company or otherwise, and whether or not such action has a detrimental effect
on the Company; provided, however, that the foregoing will not relieve (x) any of the Investors from liability associated with the unauthorized disclosure of the Company’s confidential information obtained
pursuant to this Agreement, (y) any director or officer of the Company from any liability associated with his or her fiduciary duties to the Company or (z) Takeda from its obligations under that certain Collaboration Agreement (and the
exhibits thereto) by and between the Company and Takeda, dated August 8, 2017 (as amended from time to time, the “Collaboration Agreement”). Notwithstanding the foregoing, this Section 5.6 is subject to the terms
and conditions of the Collaboration Agreement. In the event of any conflict between this Section 5.6 and the Collaboration Agreement, the terms of the Collaboration Agreement will prevail. 

5.7 Consolidation. Without the express written consent of Takeda, the Company will not take any action that would
cause Takeda to (a) own more than fifteen percent (15%) of the outstanding shares of the Company on an as-converted basis, (b) be deemed to hold a controlling interest in the Company for GAAP or
International Financial Reporting Standards (“IFRS”) purposes, or (c) otherwise be required by GAAP or IFRS to include the Company on its consolidated financial statement based on its relative ownership interest in the
Company and/or other factors. 
 5.8 CFIUS. To the extent that CFIUS requests or requires a filing with respect
to the transactions contemplated by the Purchase Agreement or that certain Series B Preferred Stock Purchase Agreement, dated as of January 31, 2020, the Investors and the Company shall use reasonable best efforts to submit the proposed
transactions to CFIUS and obtain CFIUS clearance or a statement from CFIUS that no further review is necessary with respect to such transactions. Notwithstanding the foregoing sentence, the Investors shall have no obligation to take or accept any
action, condition, or restriction as a condition of CFIUS clearance that would have a material adverse impact on the Company or the Investors’ right to exercise control over the Company. 

  
 22 

 6. TERMINATION. 

6.1 Generally. The covenants set forth in Section 2.1, Section 4 and Section 5 will terminate and
be of no further force or effect upon the earliest to occur of: (a) immediately before the consummation of the IPO; (b) when the Company first becomes subject to the periodic reporting requirements of Section 12(g) or 15(d) of the
Exchange Act; or (c) upon a Deemed Liquidation Event or a Stock Sale. 
 6.2 Registration Rights. The right
of any Holder to request registration or inclusion of Registrable Securities in any registration pursuant to Section 3.1 or Section 3.2 will terminate upon the earliest to occur of: (a) following the IPO, when all of such
Holder’s Registrable Securities could be sold without any restriction on volume or manner of sale in any three-month period under SEC Rule 144 or any successor; (b) upon a Deemed Liquidation Event or a Stock Sale; and (c) the fifth
(5th) anniversary of the IPO. 
 7. GENERAL PROVISIONS. 

7.1 Successors and Assigns. The rights under this Agreement may be assigned (but only with all related
obligations) by a Holder to a transferee of Registrable Securities that (a) is an Affiliate, partner, member, limited partner, retired or former partner, retired or former member, or stockholder of a Holder or such Holder’s Affiliate;
(b) is a Holder’s Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members; (c) after such transfer, holds at least two percent (2%) of the shares of
Registrable Securities (or if the transferring Holder owns less than two percent (2%) of the Registrable Securities, then all Registrable Securities held by the transferring Holder); or (d) is a venture capital fund that is controlled by or
under common control with one or more general partners or managing partners or managing members of, or shares the same management company with, the Holder; provided, however, that (i) the Company is, within a
reasonable time after such transfer, furnished with written notice of the name and address of such transferee and the Registrable Securities with respect to which such rights are being transferred; and (ii) such transferee agrees in a written
instrument delivered to the Company to be bound by and subject to the terms and conditions of this Agreement, including the provisions of Section 3.11. For the purposes of determining the number of shares of Registrable Securities held by a
transferee, the holdings of a transferee (A) that is an Affiliate, limited partner, retired or former partner, member, retired or former member, or stockholder of a Holder or such Holder’s Affiliate; (B) who is a Holder’s
Immediate Family Member; or (C) that is a trust for the benefit of an individual Holder or such Holder’s Immediate Family Member will be aggregated together and with those of the transferring Holder. The terms and conditions of this
Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their
respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided herein. 

7.2 Governing Law. This Agreement will be governed by, and construed in accordance with, the laws of the State of
Delaware, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws. 

  
 23 

 7.3 Counterparts. This Agreement may be executed in
counterparts, which may be transmitted by electronic means (including .pdf by email) each of which will be deemed to be an original and all of which together will be deemed to be one and the same instrument. 

7.4 Titles and Subtitles. The titles and subtitles used in this Agreement are for convenience only and are not to
be considered in construing or interpreting this Agreement. 
 7.5 Notices. 

(a) All notices, requests, and other communications given, made or delivered pursuant to this Agreement will be in writing and will be deemed
effectively given, made or delivered upon the earlier of actual receipt or: (i) personal delivery to the party to be notified; (ii) when sent, if sent by electronic mail during the recipient’s normal business hours, and if not sent
during normal business hours, then on the recipient’s next business day; (iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) business day after the
business day of deposit with a nationally recognized overnight courier, freight prepaid, specifying next-day delivery, with written verification of receipt. All communications will be sent to the respective
parties at their addresses as set forth on Schedule A or Schedule B hereto, or to the principal office of the Company and to the attention of the Chief Executive Officer, in the case of the Company, or to such address or email address as
subsequently modified by written notice given in accordance with this Section 7.5. If notice is given to the Company, it will be sent to 1018 W. 11th Street, Austin, Texas 78703, marked “Attention: Chief Executive Officer”; and copies
(which will not constitute notice) will also be sent to (a) PO Box 301509 Austin, Texas 78703, legal@shattucklabs.com, marked “Attention: General Counsel” and (b) Gibson, Dunn & Crutcher LLP, 555 Mission Street,
San Francisco, CA 94105-0921, RMurr@gibsondunn.com, Attn: Ryan Murr. If no email address is listed on Schedule A or Schedule B for a party (or above in the case of the Company), notices and communications given or made by email will not be
deemed effectively given to such party. 
 (b) Each Investor and Key Holder consents to the delivery of any stockholder notice pursuant to
the Delaware General Corporation Law (the “DGCL”), as amended or superseded from time to time, by electronic transmission pursuant to Section 232 of the DGCL (or any successor thereto) at the electronic mail address set
forth below such Investor’s or Key Holder’s name on the Schedules hereto, as updated from time to time by notice to the Company, or as on the books of the Company. Each Investor and Key Holder agrees to promptly notify the Company of any
change in such stockholder’s electronic mail address, and that failure to do so shall not affect the foregoing. 
 7.6
Amendments and Waivers. This Agreement may only be amended or terminated and the observance of any term hereof may be waived (either generally or in a particular instance, and either retroactively or prospectively) only by a
written instrument executed by the Company and the holders of at least sixty five percent (65%) of the Registrable Securities then outstanding; provided that (i) the Company may in its sole discretion waive compliance with
Section 3.12 (and the Company’s failure to object promptly in writing after notification of a proposed assignment allegedly in violation of Section 3.12 will be deemed to be a waiver); (ii) any provision hereof may be waived by any
waiving party on such party’s own behalf, without the consent of any other party; (iii) the Company may, without the consent or approval of any other party hereto, cause additional persons to become party to this Agreement as Investors
pursuant to 

  
 24 

 
Section 7.14 hereto and amend Schedule A hereto accordingly and (iv) any section referencing a particular party shall require such party’s consent for any amendment to such
party’s rights in such section. Further, this Agreement may not be amended, and no provision hereof may be waived, in each case, in any way which would adversely affect the rights of the Key Holders hereunder in a manner disproportionate to any
adverse effect such amendment or waiver would have on the rights of the Investors hereunder, without also the written consent of the holders of a majority of the Registrable Securities held by the Key Holders; provided,
however, that the grant to third parties of piggyback registration rights under Section 3.2 hereof will not be deemed to be an adverse change to the piggyback registration rights of the Key Holders under this Agreement and will
not require the consent of the Key Holders. Any amendment, termination, or waiver effected in accordance with this Section 7.6 will be binding on each party hereto and all of such party’s successors and permitted assigns, regardless of
whether or not any such party, successor or assignee entered into or approved such amendment, termination, or waiver. No waivers of or exceptions to any term, condition, or provision of this Agreement, in any one or more instances, will be deemed to
be or construed as a further or continuing waiver of any such term, condition, or provision. 
 7.7
Severability. In case any one or more of the provisions contained in this Agreement is for any reason held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability will not
affect any other provision of this Agreement, and such invalid, illegal, or unenforceable provision will be reformed and construed so that it will be valid, legal, and enforceable to the maximum extent permitted by law. 

7.8 Aggregation of Stock. All shares of Registrable Securities held or acquired by Affiliates will be aggregated
together for the purpose of determining the availability of any rights under this Agreement and such affiliated persons may apportion such rights as among themselves in any manner they deem appropriate. 

7.9 Entire Agreement. Upon the effectiveness of this Agreement, the Prior Agreement shall be deemed amended and
restated to read in its entirety as set forth in this Agreement. This Agreement (including any Schedules and Exhibits hereto), the Certificate and the other Transaction Agreements (as defined in the Purchase Agreement) constitutes the full and
entire understanding and agreement among the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly canceled and replaced with this
Agreement. 
 7.10 Third Parties. Nothing in this Agreement, express or implied, is intended to confer upon any person,
other than the parties hereto and their successors and assigns, any rights or remedies under or by reason of this Agreement. 
 7.11
Delays or Omissions. No delay or omission to exercise any right, power, or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, will impair any such right,
power, or remedy of such nonbreaching or nondefaulting party, nor will it be construed to be a waiver of or acquiescence to any such breach or default, or to any similar breach or default thereafter occurring, nor will any waiver of any single
breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. All remedies, whether under this Agreement or by law or otherwise afforded to any party, will be cumulative and not alternative. 

  
 25 

 7.12 Dispute Resolution. The parties (a) hereby irrevocably
and unconditionally submit to the jurisdiction of the federal or state courts located in the Southern District of New York for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to
commence any suit, action or other proceeding arising out of or based upon this Agreement except in the federal or state courts located in the Southern District of New York, and (c) hereby waive, and agree not to assert, by way of motion, as a
defense, or otherwise, in any such suit, action or proceeding, any claim that a party is not subject to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution based upon judgment or order of
such court(s), that any suit, action or proceeding arising out of or based upon this Agreement commenced in the federal or state courts located in the Southern District of New York is brought in an inconvenient forum, that the venue of such suit,
action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court. Should any party commence a suit, action or other proceeding arising out of or based upon this Agreement in a forum other
than the federal or state courts located in the Southern District of New York, or should any party otherwise seek to transfer or dismiss such suit, action or proceeding from such court(s), that party will indemnify and reimburse the other party for
all legal costs and expenses incurred in enforcing this provision. 
 7.13 Attorneys’ Fees. If any action
at law or in equity is necessary to enforce or interpret the terms of this Agreement, the non-prevailing party will pay all costs and expenses incurred by the prevailing party, including, without limitation,
all reasonable attorneys’ fees. 
 7.14 Additional Investors. Notwithstanding anything to the contrary
contained herein, if the Company issues additional shares of the Company’s Series B-1 Preferred Stock after the date hereof, any purchaser of such shares of Series
B-1 Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement, and thereafter will be deemed an “Investor” for all
purposes hereunder. No action or consent by the Investors will be required for such joinder to this Agreement by such additional Investor, so long as such additional Investor has agreed in writing to be bound by all of the obligations as an
“Investor” hereunder. 
 [SIGNATURE PAGES FOLLOW] 

  
 26 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and
Restated Investors’ Rights Agreement as of the date first written above. 
  

			
	COMPANY:
	
	SHATTUCK LABS, INC.
		
	By:	 	 /s/ Taylor Schreiber

	Name:	 	 Taylor Schreiber

	Title:	 	 Chief Executive Officer and President

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Redmile Biopharma Investments II, L.P.
	By:	 	Redmile Biopharma Investments II (GP), LLC,
		 	its general partner
		
	By:	 	 /s/ Joshua Garcia

	Name:	 	Joshua Garcia
	Title:	 	CFO and Authorized Signatory

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Fidelity Advisor Series VII: Fidelity Advisor
	Biotechnology Fund
		
	By:	 	 /s/ Chris Maher

	Name:	 	Chris Maher
	Title:	 	Authorized Signatory
	
	Fidelity Select Portfolios: Health Care Portfolio
		
	By:	 	 /s/ Chris Maher

	Name:	 	Chris Maher
	Title:	 	Authorized Signatory
	
	Fidelity Advisor Series VII: Fidelity Advisor
	Health Care Fund
		
	By:	 	 /s/ Chris Maher

	Name:	 	Chris Maher
	Title:	 	Authorized Signatory

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Janus Henderson Global Life Sciences Fund
		
	By:	 	Janus Capital Management LLC, its investment advisor
		
	By:	 	 /s/ Andrew Acker

	Name:	 	Andrew Acker
	Title:	 	Authorized Signatory
	
	Janus Henderson Capital Funds plc on behalf of its
	series Janus Henderson Global Life Sciences Fund
		
	By:	 	Janus Capital Management LLC, its investment advisor
		
	By:	 	 /s/ Andrew Acker

	Name:	 	Andrew Acker
	Title:	 	Authorized Signatory
	
	Janus Henderson Horizon Fund – Biotechnology Fund
		
	By:	 	Janus Capital Management LLC, its investment advisor
		
	By:	 	 /s/ Andrew Acker

	Name:	 	Andrew Acker
	Title:	 	Authorized Signatory
	
	Janus Henderson Biotech Innovation Master Fund Limited
		
	By:	 	Janus Capital Management LLC, its investment advisor
		
	By:	 	 /s/ Andrew Acker

	Name:	 	Andrew Acker
	Title:	 	Authorized Signatory

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	EcoR1 Capital Fund, L.P.
		
	By:	 	EcoR1 Capital, LLC, its General Partner
		
	By:	 	 /s/ Oleg Nodelman

	Name:	 	Oleg Nodelman
	Title:	 	Manager
	
	EcoR1 Capital Fund Qualified, L.P.
		
	By:	 	EcoR1 Capital, LLC, its General Partner
		
	By:	 	 /s/ Oleg Nodelman

	Name:	 	Oleg Nodelman
	Title:	 	Manager
	
	EcoR1 Venture Opportunity Fund, L.P.
		
	By:	 	Biotech Opportunity GP, LLC, its General Partner
		
	By:	 	 /s/ Oleg Nodelman

	Name:	 	Oleg Nodelman
	Title:	 	Manager

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Hatteras Venture Partners VI, LP
		
	By:	 	Hatteras Venture Advisors VI, LLC,
		 	its general partner
		
	By:	 	 /s/ Douglas Reed

	Name:	 	Douglas Reed
	Title:	 	Manager
	
	Hatteras NC Fund, LP
		
	By:	 	Hatteras Venture Advisors IV, LLC,
		 	its general partner
		
	By:	 	 /s/ Douglas Reed

	Name:	 	Douglas Reed
	Title:	 	Manager

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	PFM Healthcare Master Fund, L.P.
		
	By:	 	Partner Fund Management, L.P.,
		 	its investment adviser
		
	By:	 	 /s/ Yuan DuBord

	Name:	 	Yuan DuBord
	Title:	 	Chief Financial Officer

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Emerson Collective Investments, LLC
		
	By:	 	 /s/ Steve McDermid

	Name:	 	Steve McDermid
	Title:	 	Authorized Signatory

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Avidity Master Fund LP
	By:	 	Avidity Capital Partners Fund (GP) LP
	By:	 	Avidity Capital Partners (GP) LLC, its general partner
		
	By:	 	 /s/ Michael Gregory

	Name:	 	Michael Gregory
	Title:	 	Managing Member
	
	Avidity Capital Fund II LP
	By:	 	Avidity Capital Partners Fund (GP) LP
	By:	 	Avidity Capital Partners (GP) LLC, its general partner
		
	By:	 	 /s/ Michael Gregory

	Name:	 	Michael Gregory
	Title:	 	Managing Member

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	Piper Sandler & Co.
		
	By:	 	 /s/ Timothy L. Carter

	Name:	 	Timothy L. Carter
	Title:	 	Chief Financial Officer

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Clover Field Enterprises, LLC

	(Please print or type full name of Investor) 	 		 	(Please print or type full name of Investor) 
					
	By:	 	  
	 		 	By:	 	 /s/ Stephen Hemsley

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Stephen Hemsley

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 President

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 OBP Holdings LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Tom Daniel

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Tom Daniel

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Manager

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Anna Hargrove and Reg Hargrove
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Anna Hargrove
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
	By:	 	 /s/ Reg Hargrove
	 		 	Name:	 	  

	(Signature)	 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Elizabeth S. Loewenbaum
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Elizabeth S. Loewenbaum
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Paul Shiverick
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Paul Shiverick
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Mark Fabry
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Mark Fabry
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Clark BP, LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Stephen M. Duff

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Stephen M. Duff

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Co-Manager

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 ECMC Group, Inc.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Greg Van Guilder

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Greg Van Guilder

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Chief Investment Officer

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Pines Edge LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ John Hinck

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 John Hinck

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 President and CEO of Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Daniel A. Traylor
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Daniel A. Traylor
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 LAD Trust

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ LAD Trust

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 LAD Trust

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 President of Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Lowe Interests, L.P.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Geoffrey Perrin

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Geoffrey Perrin

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 CFO

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Montrose Investments Fund I, L.P.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Will Rose

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Will Rose

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Authorized Signatory

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Puffin Partners, L.P.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Will Rose

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Will Rose

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Authorized Signatory

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 S&G Foundation

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Lanse Davis

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Lanse Davis

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Treasurer

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Traylor Capital, LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Daniel A. Traylor

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Daniel A. Traylor

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Managing Principal

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Millennium Pharmaceuticals, Inc.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Michael Martin

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Michael Martin

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 President, Takeda Ventures, Inc.

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 Charles Dorrance
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ Charles Dorrance
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Delphinium, Inc.

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ John T. Dorrance

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 John T. Dorrance

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Director

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 GSD Revocable Trust 2011

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ James B. Hoar

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 James B. Hoar

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	 G. Walter Loewenbaum
	 		 	Name:	 	  

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	 /s/ G. Walter Loewenbaum
	 		 	By:	 	  

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	  

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	  

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Strata Trust Company Custodian FBO George Walter Loewenbaum Account# 201207360

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Melissa Coffman

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Melissa Coffman

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Alt Corp. Signer

		 		 		 	(Please print or type full title)
				
		 		 		 	Read and Approved
				
		 		 		 	/s/ G. Walter Loewenbaum
				
		 		 		 	G. Walter Loewenbaum

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 The Loewenbaum 1992 Trust

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ G. Walter Loewenbaum

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 G. Walter Loewenbaum

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 The Waterproof Partnership, LTD

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ G. Walter Loewenbaum

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 G. Walter Loewenbaum

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 General Partner

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Lennox Dallas Partners, LP

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
				
		 		 	By:	 	RS Holdings, Inc., its general partner
					
	By:	 	  
	 		 	By:	 	 /s/ Tyler Brous

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Tyler Brous

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 VP of RS Holdings, Inc.

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Lennox Dallas Holdings, LLC – Series 9

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
				
		 		 	By:	 	RS Holdings, Inc., its manager
					
	By:	 	  
	 		 	By:	 	 /s/ Tyler Brous

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Tyler Brous

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 VP of RS Holdings, Inc.

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Lennox Dallas Holdings, LLC – Series 3

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
				
		 		 	By:	 	RS Holdings, Inc., its manager
					
	By:	 	  
	 		 	By:	 	 /s/ Tyler Brous

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Tyler Brous

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 VP of RS Holdings, Inc.

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Lennox Dallas Holdings, LLC – Series 10

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Tyler Brous

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Tyler Brous

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Manager

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 INVESTORS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 David G. Lowe and Ann M. Lowe, as Trustee of the Lowe Family Trust dated December 11, 1991

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ David Lowe

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 David Lowe

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 HEY HOLDERS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Houghton Capital Holdings, LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Taylor Schreiber

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Taylor Schreiber

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Principal

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 KEY HOLDERS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Hornblower Capital Holdings, LLC

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Josiah Hornblower

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Josiah Hornblower

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Managing Partner

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement) 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Investors’ Rights Agreement as of the date first written above. 
 KEY HOLDERS: 

 

									
	IF AN INDIVIDUAL:	 		 	IF AN ENTITY:
				
	  
	 		 	Name:	 	 Moorea Trust

	(Please print or type full name of Key Holder)	 		 	(Please print or type full name of Key Holder)
					
	By:	 	  
	 		 	By:	 	 /s/ Josiah Hornblower

	(Signature)	 		 	(Duly authorized signature)
					
		 		 		 	Name:	 	 Josiah Hornblower

		 		 		 	(Please print or type full name of signatory)
					
		 		 		 	Title:	 	 Trustee

		 		 		 	(Please print or type full title)

  
 (Signature Page to
Shattuck Labs, Inc. 
 Second Amended and Restated Investors’ Rights Agreement)

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00314-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00314-of-00352.parquet"}]]