Document:

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                                                                  Exhibit 10.20

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS
([*]), HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED

                                LICENSE AGREEMENT

         THIS AGREEMENT, effective as of March 15, 2002 ("EFFECTIVE DATE"), is
made by and between THE GENERAL HOSPITAL CORPORATION, a not-for-profit
corporation doing business as Massachusetts General Hospital, having a place of
business at Fruit Street, Boston, Massachusetts 02114 ("GENERAL"), and VIACELL
ENDOCRINE SCIENCE, INC., a subsidiary of ViaCell, Inc., having offices at 131
Clarendon Street, Boston, Massachusetts 02116 ("VIACELL").

         WHEREAS, under research programs funded by the Howard Hughes Medical
Institute ("HHMI"), GENERAL and the U.S. Government, HHMI and GENERAL, through
research conducted by Dr. Joel Habener, Dr. Denise Faustman and their
colleagues, having developed inventions pertaining to pancreatic stem cells for
treatment of diabetes;

         WHEREAS, GENERAL has filed U.S. and foreign patent applications
covering said inventions;

         WHEREAS, pursuant to the Patent and Intellectual Property Agreement
between HHMI and GENERAL dated November 16, 1987, all of Dr. Joel Habener's and
other HHMI employees' rights, title and interest in said applications have been
assigned by HHMI to GENERAL;

         WHEREAS, all of Dr. Denise Faustman's rights, title and interest in
said applications have been assigned to GENERAL;

         WHEREAS, GENERAL represents to the best of its knowledge and belief
that it is the owner of all rights, title and interest in said patent
applications and has the right and ability to grant the licenses hereinafter
described;

         WHEREAS, as centers for research and education, GENERAL and HHMI are
interested in licensing said patent applications and thus benefiting the public,
and in facilitating the dissemination of the results of research in the form of
useful products, but are without capacity to commercially develop, manufacture,
and distribute any such product; and

         WHEREAS, VIACELL having such capacity, desires to commercially develop,
manufacture, use and distribute such products throughout the world;

         NOW THEREFORE, in consideration of the premises and of the faithful
performance of the covenants herein contained, the parties hereto agree as
follows:

                                 1. DEFINITIONS

         1.1 The term "ACCOUNTING PERIOD" shall mean each six-month period
ending June 30 and December 31.

         1.2 The term "AFFILIATE" with respect to VIACELL shall mean any
corporation or other legal entity controlling, controlled by or under common
control with VIACELL. The term

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
"AFFILIATE" with respect to GENERAL shall mean any company controlling,
controlled by, or under common control with GENERAL. The term "control" means
possession, direct or indirect, of the powers to direct or cause the direction
of the management and policies of an entity, whether through the ownership of
voting securities, by contract or otherwise.

         1.3 The term "FIRST COMMERCIAL SALE" shall mean in each country the
first sale of any PRODUCT by VIACELL, its AFFILIATES or SUBLICENSEES.

         1.4 The term "LICENSE FIELD" shall mean the diagnosis, treatment or
prevention of human and animal diseases and conditions.

         1.5 The term "NET SALE PRICE" shall mean the GROSS SALES PRICE as
defined in (b) below received by VIACELL or any of its AFFILIATES or
SUBLICENSEES ("SELLERS") for the sale or distribution of any PRODUCT to a final
customer who will be the end user of the PRODUCT and is not an AFFILIATE or
SUBLICENSEE ("CUSTOMER"), less (to the extent appropriately documented) the
following amounts actually paid out by VIACELL, its AFFILIATE or SUBLICENSEE or
credited against the amounts received by them from the sale or distribution of
PRODUCT:

              (a) (i) credits and allowances for price adjustment, rejection,
or return of PRODUCTS previously sold;

                  (ii) rebates and cash discounts to purchasers allowed and
taken;

                  (iii) amounts for transportation, insurance, handling or
shipping charges to purchasers;

                  (iv) taxes, duties and other governmental charges levied on or
measured by the sale of PRODUCTS, whether absorbed by VIACELL or paid by the
purchaser so long as VIACELL's price is reduced thereby, but not franchise or
income taxes of any kind whatsoever;

                  (v) charge back payments and/or rebates for PRODUCTS provided
to managed health care organizations, international organizations, or federal,
state, local or other governments, including for example in the United States,
Medicare and Medicaid; and

                  (vi) for any sale in which the United States government on the
basis of its royalty-free license pursuant to 35 USC Sec. 202(c) to any PATENT
RIGHT requires that the GROSS SALES PRICE of any PRODUCT subject to such PATENT
RIGHT be reduced by the amount of such royalty owed GENERAL pursuant to
Paragraph 3.1, the amount of such royalty.

              (b) For any bona fide sale to a bona fide CUSTOMER by VIACELL or
any of its AFFILIATES or SUBLICENSEES, the GROSS SALES PRICE shall be the gross
billing price of the PRODUCT.

                                       2
* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
              (c) If VIACELL or any of its AFFILIATES or SUBLICENSEES sell any
PRODUCT in a bona fide sale as a component of a combination of active functional
elements, the GROSS SALES PRICE of the PRODUCT shall be determined by
multiplying the GROSS SALES PRICE of the combination of the fraction A over A +
B, in which "A" is the GROSS SALES PRICE of the PRODUCT portion of the
combination when sold separately during the ACCOUNTING PERIOD in the country in
which the sale was made, and "B" is the GROSS SALES PRICE of the other active
elements of the combination sold separately during said ACCOUNTING PERIOD in
said country. In the event that no separate sale of either such PRODUCT or
active elements of the combination is made during said ACCOUNTING PERIOD in said
country, the GROSS SALES PRICE of the PRODUCT shall be determined by multiplying
the GROSS SALES PRICE of such combination by the fraction C over C + D, in which
"C" is the standard fully-absorbed cost of the PRODUCT portion of such
combination, and "D" is the sum of the standard fully-absorbed costs of the
other active elements component(s), such costs being arrived at using the
standard accounting procedures of VIACELL which will be in accord with generally
accepted accounting practices.

              (d) If a SELLER commercially uses or disposes of any PRODUCT by
itself (as opposed to use or disposition of the PRODUCT as a component of a
combination of active functional elements) other than in a bona fide sale to a
bona fide CUSTOMER, the GROSS SALES PRICE hereunder shall be the price which
would be then payable in an arm's length transaction with such a CUSTOMER; and
if a SELLER commercially uses or disposes of any PRODUCT as a component of a
combination of active functional elements other than in a bona fide sale to a
bona fide customer, the GROSS SALES PRICE of the PRODUCT shall be determined in
accordance with Paragraph 1.5(c) above, using as the GROSS SALES PRICE of the
combination that price which would be then payable in an arm's length
transaction; provided, however, that SELLERS may use or dispose of PRODUCTS for
clinical trials, and the GROSS SALES PRICE with respect to such PRODUCTS shall
be calculated based on the price, if any, actually billed therefor.

              (e) Transfer of a PRODUCT within VIACELL or between VIACELL and an
AFFILIATE for sale by the transferee shall not be considered a sale, commercial
use or disposition for the purpose of the foregoing paragraphs; in the case of
such transfer the GROSS SALES PRICE shall be based on sale of the PRODUCT by the
transferee.

         1.6 The term "PATENT RIGHT" shall mean the U.S. and foreign patent
applications listed on APPENDIX A, or the equivalent of such applications,
including, without limitation, any division, continuation or any foreign patent
application or Letters Patent or the equivalent thereof issuing thereon or
reissue, reexamination or extension thereof. PATENT RIGHTS shall also include
those claims in any continuation-in-part of the aforementioned patent
applications directed to subject matter specifically described or claimed in
said patent applications.

         1.7 The term "PRODUCT" shall mean any article, device, composition,
method or service the manufacture, use, or sale of which

                                       3

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
              (a) absent the licenses granted herein, would infringe a VALID
CLAIM of any PATENT RIGHT, or

              (b) does not infringe a VALID CLAIM of any PATENT RIGHT licensed
to VIACELL hereunder, but the discovery, development, manufacture or use of
which requires or materially employs non-public KNOW-HOW.

         1.8 The term "SUBLICENSEE" shall mean any non-AFFILIATE third party
granted a license by VIACELL or by an AFFILIATE pursuant to Paragraph 2.1(d). As
used in this Agreement, "SUBLICENSEE" shall include, without limitation, any
third party to whom VIACELL or an AFFILIATE has granted, directly or indirectly,
the right to distribute a PRODUCT, provided that such third party has the
responsibility in whole or in part for marketing and/or promotion of the PRODUCT
within the territory for which such distribution rights are granted.

         1.9 The term "SUBLICENSEE REVENUE" shall mean any payments that VIACELL
receives from a SUBLICENSEE in consideration of the sublicense of the rights
granted to VIACELL under Article 2 including, without limitation, license fees,
milestone payments and license maintenance fees, but excluding the following
payments: (a) royalties on NET SALES by the SUBLICENSEE for which GENERAL
receives its royalties pursuant to Paragraph 5.1, (b) payments made in
consideration of the issuance of equity or debt securities of VIACELL at fair
market value, and (c) payments specifically committed to the research or
development of PRODUCTS actually conducted by or for VIACELL, whether in the
form of funding for future costs or reimbursement for costs previously incurred.

         1.10 The term "KNOW-HOW" shall mean any unpatented technical
information, research data, designs, formulas, process information, clinical
data and other information which is known to Dr. Joel Habener on the EFFECTIVE
DATE and which GENERAL has the right to license, necessary for the exercise or
use of the PATENT RIGHTS in the LICENSE FIELD.

         1.11 The term "VALID CLAIM" shall mean any unexpired issued claim or
pending claim prosecuted in good faith of any PATENT RIGHT that has not been (i)
finally rejected, (ii) declared invalid or unenforceable by a patent office or
court of competent jurisdiction in any unappealed and unappealable decision or
(iii) admitted to be invalid or unenforceable through reissue or disclaimer or
otherwise by the holder thereof.

                                   2. LICENSE

         2.1 GENERAL hereby grants VIACELL, to the extent not prohibited by the
United States Government:

              (a) an exclusive, worldwide, royalty-bearing license in the
LICENSE FIELD under GENERAL's rights in PATENT RIGHTS to make, have made, use,
sell, offer for sale and import PRODUCTS;

                                       4

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
              (b) to the extent an exclusive license is not available to VIACELL
in a country, due to legal or regulatory action in such country, a
non-exclusive, royalty-bearing license in such country in the LICENSE FIELD
under PATENT RIGHTS to make, have made, use, sell, offer for sale and import
PRODUCTS;

              (c) a non-exclusive, worldwide fully paid-up license to use the
KNOW-HOW in the LICENSE FIELD;

              (d) the right to sublicense PATENT RIGHTS and KNOW-HOW licensed to
VIACELL.

         The above licenses to sell PRODUCTS include, without limitation, the
right to grant to the purchaser or recipient of products from VIACELL, its
AFFILIATES, and SUBLICENSEES the right to use such purchased PRODUCTS in a
method coming within the scope of PATENT RIGHTS.

         2.2 (a) It is understood that the granting of any license hereunder is
subject to GENERAL's and GENERAL's AFFILIATES' right to make and to use the
subject matter described and claimed in all PATENT RIGHTS for research, clinical
and educational purposes but for no other purpose, and that if federal funding
supported any PATENT RIGHT, VIACELL's license will be subject to the rights,
conditions and limitations imposed by U.S. law including without limitation the
royalty-free non-exclusive license granted to the U.S. government (see 35 U.S.C.
Section 202 et seq. and regulations pertaining thereto).

              (b) It is further understood that all rights granted in this
Agreement are expressly granted subject to HHMI's institution-wide, paid-up,
non-exclusive, irrevocable license to use the subject matter described and
claimed in all PATENT RIGHTS for its research and other non-commercial purposes
but for no other purpose, without the right to sublicense or assign.

         2.3 Upon request by VIACELL, GENERAL, acting through Dr. Joel Habener,
shall disclose to VIACELL KNOW-HOW. A summary of non-public KNOW-HOW to be
transferred hereunder is attached as APPENDIX D, which may be modified from time
to time by mutual written agreement of the parties (e.g. in the event that such
KNOW-HOW becomes public).

         2.4 GENERAL shall promptly inform VIACELL of any new patent
applications that name Dr. Joel Habener as inventor and that claim the use of
stem cells for treatment of diabetes, provided that such applications are not
encumbered by an agreement with a third party. However, it is understood that
nothing in this Agreement shall be construed to grant VIACELL a license express
or implied under any patent owned solely or jointly by GENERAL other than the
PATENT RIGHTS expressly licensed hereunder.

                          3. DUE DILIGENCE OBLIGATIONS

                                       5

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
         3.1 VIACELL shall itself, or through its AFFILIATES or SUBLICENSEES,
use its reasonable best efforts, based on reasonable business judgment, to
develop and make commercially available PRODUCTS for commercial sales and
distribution throughout the world in the LICENSE FIELD. Such efforts shall
include the following:

         VIACELL shall perform the pre-clinical research and development work
defined in APPENDIX B ("INITIAL OBJECTIVE") within the first 18 months following
the EFFECTIVE DATE. VIACELL, through its parent company, ViaCell, Inc., will
provide funding of $2 million to complete the INITIAL OBJECTIVES. The parties
agree that this sum may need to be revised as a function of the agreed-upon
objectives and shall only include those costs directly incurred in the research
and development of a PRODUCT. VIACELL shall have its own laboratory space,
scientific personnel, and medical/scientific advisory board, which shall be
established and maintained (or, in the case of personnel, hired and employed) at
VIACELL's discretion as needed to achieve the INITIAL OBJECTIVES and any other
development objectives. As a subsidiary of ViaCell, Inc., VIACELL shall have
access to additional personnel and resources of ViaCell, Inc. as needed to
achieve the INITIAL OBJECTIVES and any other development objectives.

         Within sixty (60) days following completion of the INITIAL OBJECTIVES,
VIACELL shall meet the GENERAL and the inventors, to the extent they wish to
participate, to present and discuss the following: (i) results of the initial
research and development work; (ii) proposed business plan for VIACELL; and
(iii) proposed clinical development plan and a commercially reasonable
development timeline. GENERAL and VIACELL shall adopt further time-limited
performance objectives at that time, which objectives shall be appended to this
Agreement as APPENDIX C. Such objectives may include taking the following steps
within defined timeframes: to complete all animal toxicity tests required in
connection with securing U.S. Food and Drug Administration ("FDA") approval of
clinical evaluations thereof; to initiate and thereafter diligently pursue
clinical evaluations of a PRODUCT and in connection therewith take all actions
reasonably necessary under the Food, Drug and Cosmetic Act (21 USC 301-391); to
introduce PRODUCT into all commercially feasible markets.

         Provided, however, that GENERAL shall not unreasonably withhold its
consent to any revision in any time periods specified herein or established in
accordance with this Paragraph 3.1 whenever requested in writing by VIACELL and
supported by evidence of technical difficulties or delays that VIACELL could not
have reasonably avoided. Failure to achieve any objective within the above
stated time periods, or within the time periods established in accordance with
this Paragraph 3.1 or within any extension granted by GENERAL shall result in
GENERAL having the right to cancel upon thirty (30) days notice any exclusive
license granted hereunder or convert any exclusive license to a non-exclusive
license.

         3.2 In the event there is a disagreement between the parties regarding
the proposed business or clinical plans, the parties will engage an objective
third party to advise on the matter and recommend an optimal plan.

                                       6
* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
         3.3 VIACELL shall invite Dr. Joel Habener and Dr. Denise Faustman to
participate as members of the medical/scientific advisory board of VIACELL under
separate consulting agreements.

         3.4 At intervals no longer than every six (6) months, VIACELL shall
report in writing to GENERAL on progress made toward the development and
commercialization of PRODUCTS.

4. FILING, PROSECUTION AND MAINTENANCE OF PATENT RIGHTS AND JOINT PATENT RIGHTS

         4.1 (a) GENERAL shall be responsible for the preparation, filing,
prosecution and maintenance of all patent applications and patents included in
PATENT RIGHTS, at VIACELL's expense. GENERAL shall control patent prosecution of
all PATENT RIGHTS using outside patent counsel acceptable to VIACELL in such
countries as VIACELL shall reasonably specify.

              (b) VIACELL shall reimburse GENERAL for all reasonable costs for
the preparation, filing, prosecution and maintenance of all PATENT RIGHTS
("COSTS") incurred by GENERAL prior to the EFFECTIVE DATE ("PAST PATENT COSTS").
Reimbursement to GENERAL shall be made as follows: Within sixty (60) days
following the execution of this Agreement, GENERAL shall submit to VIACELL an
invoice of the PAST PATENT COSTS, supported by appropriate documentation.
VIACELL shall pay GENERAL fifty percent (50%) of the PAST PATENT COSTS reported
on such invoice within 30 days of receiving said invoice and shall pay the
balance of the PAST PATENT COSTS reported on said invoice on the first
anniversary of the EFFECTIVE DATE. PAST PATENT COSTS are estimated at forty-one
thousand four hundred seventy six dollars and ninety-two cents ($41,476.92),
however, the total COSTS incurred by GENERAL and supported by appropriate
documentation shall be considered the amount of PAST PATENT COSTS to be
reimbursed by VIACELL in accordance with this Paragraph 4.1(b).

              (c) Subject to Paragraph 4.2, VIACELL shall reimburse GENERAL for
all COSTS incurred by GENERAL after the EFFECTIVE DATE and during the term of
this Agreement, within thirty (30) days of receipt of invoices from GENERAL or
its outside counsel as contemplated herein.

         4.2 With respect to any PATENT RIGHT, each document or a draft thereof
pertaining to the filing, prosecution, or maintenance of such PATENT RIGHT,
including but not limited to each patent application, office action, response to
office action, request for terminal disclaimer, and request for reissue or
reexamination of any patent issuing form such application shall be provided to
VIACELL as follows. Documents received from any patent office or counsel's
analysis thereof shall be provided promptly after receipt. For a document to be
filed in any patent office, a draft of such document shall be provided
sufficiently prior to its filing, to the extent practicable at least fourteen
days, to allow for review and comment by VIACELL.

                                       7

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
VIACELL shall have the right to participate in, comment upon and make
recommendations regarding the course of patent prosecution, which
recommendations GENERAL agrees to follow except to the extent such
recommendations result, in GENERAL's determination, in an unwarranted narrowing
of PATENT RIGHTS. In no event shall GENERAL allow the PATENT RIGHTS to be
narrowed without providing advance written notice to VIACELL.

         4.3 If VIACELL shall elect not to pay or continue to pay the COSTS for
any PATENT RIGHT, VIACELL shall so notify GENERAL promptly and VIACELL shall
thereafter be relieved of the obligation to pay any additional COSTS regarding
such PATENT RIGHT incurred after the receipt of such notice by GENERAL. Such
U.S. or foreign patent application or patent shall thereupon cease to be a
PATENT RIGHT hereunder and GENERAL shall be free to prosecute or maintain such
PATENT RIGHT at its own expense and to license its rights to that particular
PATENT RIGHT to any other party on any terms.

                                  5. PAYMENTS

         5.1 Beginning with the FIRST COMMERCIAL SALE in any country, on all
sales of PRODUCTS anywhere in the world by VIACELL, its AFFILIATES or
SUBLICENSEES, VIACELL shall pay GENERAL royalties in accordance with the
following schedule, such undertaking and schedule having been agreed to for the
purpose of reflecting and advancing the mutual convenience of the parties. For
each PRODUCT sold by VIACELL or its AFFILIATES and SUBLICENSEES:

              (a) [*] of the NET SALES PRICE so long as the PRODUCT, its
manufacture, use or sale is covered by a VALID CLAIM of any PATENT RIGHT in the
country of sale licensed exclusively to VIACELL; and

              (b) [*] of the NET SALES PRICE whenever the PRODUCT, its
manufacture, use or sale is covered by VALID CLAIM of any PATENT RIGHT in the
country of sale licensed non-exclusively to VIACELL; and

              (c) During each of the ten (10) years next following the FIRST
COMMERCIAL SALE anywhere in the world by VIACELL, its AFFILIATES or
SUBLICENSEES, [*] of the NET SALES PRICE on which no royalty is payable under
Paragraph 5.1(a) or 5.1(b) above.

         5.2 (a) In the event that more than one royalty rate under Paragraph
5.1 is applicable to a PRODUCT, the highest of the applicable royalties shall
apply.

              (b) Only one royalty under Paragraph 5.1 shall be due and payable
to GENERAL by VIACELL for any PRODUCT regardless of the number of PATENT RIGHTS
covering such PRODUCT.

              (c) In the event VIACELL is required to license any technology of
a third party in order to make, use, sell, offer for sale or import PRODUCTS,
then the royalty payment

                                       8

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
due to GENERAL under Paragraph 5.1 shall be reduced by fifty percent (50%) of
the royalties paid by VIACELL under such third party license; provided, however,
that in no event shall the royalty payable to GENERAL under Paragraph 5.1 be
reduced by more than fifty percent (50%) in any ACCOUNTING PERIOD.

              (d) If any license granted pursuant to Article 2 shall be or
become non-exclusive and GENERAL shall license any PATENT RIGHT to another
licensee for the purpose of making, using, selling, offering for sale or
importing PRODUCTS and accept a royalty or royalties more favorable to such
licensee than herein provided for, GENERAL shall give written notice thereof to
VIACELL AND as of the effective time of such more favorable royalty or
royalties, VIACELL's obligation hereunder to pay royalty or royalties to GENERAL
shall be revised to the more favorable rate provided the licensee.

              (e) In the event that the royalty paid to GENERAL hereunder is a
significant factor in the return realized by VIACELL so as to diminish VIACELL's
capability to respond to competitive pressures in the market, GENERAL agrees to
consider a reasonable reduction in the royalty paid to GENERAL as to each such
PRODUCT for the period during which such market condition exists. Factors
determining the size of the reduction will include profit margin on PRODUCT and
on analogous products, prices of competitive products, total prior sales by
VIACELL, and VIACELL's expenditures in PRODUCT development.

         5.3 Subject to Paragraph 5.4, VIACELL shall pay GENERAL [*] of all
SUBLICENSEE REVENUE received by VIACELL. Such payments shall be due and payable
within sixty (60) days after VIACELL receives the relevant payment from the
SUBLICENSEE.

         5.4 VIACELL shall pay GENERAL the following amounts upon the occurrence
of the following milestones, which amounts are due no more than once for each
PRODUCT:

              (a) upon filing the first Investigational New Drug (IND)
application for each PRODUCT by VIACELL or an AFFILIATE or SUBLICENSEE: the
greater of (i) [*] or (ii) [*] of any SUBLICENSEE REVENUE received by VIACELL
attributable to this event;

              (b) upon commencement of the first Phase III clinical trial of
each PRODUCT by VIACELL or an AFFILIATE or SUBLICENSEE: the greater of (i) [*]
or (ii) [*] of any SUBLICENSEE REVENUE received by VIACELL attributable to the
commencement of the first Phase III clinical trial of such PRODUCT;

              (c) upon filing with the FDA of the first Biologics License
Application (BLA), or comparable application with respect to each PRODUCT by
VIACELL or an AFFILIATE or SUBLICENSEE: the greater of (i) [*] or (ii) [*] of
any SUBLICENSEE REVENUE received by VIACELL attributable to the filing with the
FDA of the first BLA or comparable application with respect to such PRODUCT; and

                                       9

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
              (d) upon approval by the FDA of the first BLA or comparable
application with respect to each PRODUCT by VIACELL or an AFFILIATE or
SUBLICENSEE: the greater of (i) [*] or (ii) [*] of any SUBLICENSEE REVENUE
received by VIACELL attributable to the approval by the FDA of the first BLA or
comparable application with respect to such PRODUCT.

         5.5 VIACELL shall pay GENERAL an annual minimum payment of thirty
thousand dollars ($30,000) per calendar year, commencing with the calendar year
beginning thirty (30) months from the EFFECTIVE DATE, i.e. on September 15,
2004. The annual minimum payment for each year shall be due within thirty (30)
days of said month and day, and VIACELL may credit all payments made to GENERAL
under this Article 5 during the prior twelve (12) month period against such
annual minimum payment due each year.

         5.6 The payments due under this Agreement shall, if overdue, bear
interest until payment at a per annum rate equal to one percent (1%) above the
prime rate in effect at the Fleet Bank on the due date, not to exceed the
maximum permitted by law. The payment of such interest shall not preclude
GENERAL from exercising any other rights it may have as a consequence of the
lateness of any payment.

                            6. REPORTS AND PAYMENTS

         6.1 VIACELL shall keep, and shall cause each of its AFFILIATES and
SUBLICENSEES, if any, to keep full and accurate books of accounts containing all
particulars that may be necessary for the purpose of calculating all royalties
payable to GENERAL. Such books of account shall be kept at their principal place
of business and, with all necessary supporting data shall, during all reasonable
times, for the three (3) years next following the end of the calendar year to
which each shall pertain, be open for inspection at reasonable times after
reasonable written notice by GENERAL or its designee at GENERAL's expense for
the purpose of verifying royalty statements or compliance with this Agreement.
If the results of such audit demonstrate under-reporting of greater than five
percent (5%) VIACELL shall pay the costs of the audit.

         6.2 In each year the amount of royalty due shall be calculated
semiannually as of the end of each ACCOUNTING PERIOD and shall be paid
semiannually within the sixty (60) days next following such date, every such
payment to be supported by the accounting prescribed in Paragraph 6.3 and to be
made in United States currency. Whenever conversion from any foreign currency
shall be required, such conversion shall be at the rate of exchange thereafter
published in the Wall Street Journal for the business day closest to the end of
the applicable ACCOUNTING PERIOD.

         6.3 With each semiannual payment, VIACELL shall deliver to GENERAL a
full and accurate accounting to include at least the following information:

                                       10

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
              (a) Quantity of each PRODUCT sold or leased (by country) by
VIACELL, and its AFFILIATES or SUBLICENSEES;

              (b) Total billings for each PRODUCT (by country);

              (c) Quantities of each PRODUCT used by VIACELL and its AFFILIATES
or SUBLICENSEES;

              (d) Names and addresses of all SUBLICENSEES of VIACELL; and

              (e) Total royalties payable to GENERAL.

                                7. INFRINGEMENT

         7.1 GENERAL will protect its PATENT RIGHTS from infringement and
prosecute infringers when, in its sole judgement, such action may be reasonably
necessary, proper and justified.

         7.2 If VIACELL shall have supplied GENERAL with written evidence
demonstrating to GENERAL's reasonable satisfaction prima facie infringement of a
claim of a PATENT RIGHT in the LICENSE FIELD by a third party, VIACELL may by
notice request GENERAL to take steps to protect the PATENT RIGHT. GENERAL shall
notify VIACELL within three (3) months of the receipt of such notice whether
GENERAL intends to prosecute the alleged infringement. If GENERAL notifies
VIACELL that it intends to prosecute, GENERAL shall, within three (3) months of
its notice to VIACELL either (i) cause infringement to terminate or (ii)
initiate legal proceedings against the infringer. In the event GENERAL notifies
VIACELL that GENERAL does not intend to prosecute said infringement VIACELL may,
upon notice to GENERAL, initiate legal proceedings against the infringer at
VIACELL's expense and in GENERAL's name if so required by law. No settlement,
consent judgment or other voluntary final disposition of the suit which
invalidates or restricts the claims of such PATENT RIGHTS may be entered into
without the consent of GENERAL, which consent shall not be reasonably withheld.
VIACELL shall indemnify GENERAL against any order for payment that may be made
against GENERAL in such proceedings.

         7.3 In the event one party shall initiate or carry on legal proceedings
to enforce any PATENT RIGHT against any alleged infringer or defend a
declaratory judgment action as provided in Paragraph 7.5, the other party shall
fully cooperate with and supply all assistance reasonably requested by the party
initiating or carrying on such proceedings. The party which institutes any suit
to protect or enforce a PATENT RIGHT shall have sole control of that suit and
shall bear the reasonable expenses (excluding legal fees) incurred by said other
party in providing such assistance and cooperation as is requested pursuant to
this Paragraph 7.3. The party initiating or carrying on such legal proceedings
shall keep the other party informed of the progress of such proceeding and aid
other party shall be entitled to counsel in such proceedings but at its own
expense. Any award paid by third parties as the result of such proceeding

                                       11

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
(whether by way of settlement or otherwise) shall first be applied to
reimbursement of the unreimbursed legal fees and expenses incurred by either
party and the payment to GENERAL of royalties withheld pursuant to Paragraph
7.6, and then the remainder shall be divided between the parties as follows:

              (a) (i) If the amount is based on lost profits, VIACELL shall
receive an amount equal to the damages the court determines VIACELL has suffered
as a result of the infringement less the amount of any royalties that would have
been due GENERAL on sales of PRODUCT lost by VIACELL as a result of the
infringement had VIACELL made such sales; and

                  (ii) GENERAL shall receive an amount equal to the royalties it
would have received if such sales had been made by VIACELL; and

               (b) As to awards other than those based on lost profits, sixty
percent (60%) to the party initiating such proceedings and forty percent (40%)
to the other party.

         7.4 For the purpose of the proceedings referred to in this Article 7,
the GENERAL and VIACELL shall permit the use of their names and shall execute
such documents and carry out such other acts as may be necessary. The party
initiating or carrying on such legal proceedings shall keep the other party
informed of the progress of such proceedings and said other party shall be
entitled to counsel in such proceedings but at its own expense, said expenses to
be offset against any damages received by the party bringing suit in accordance
with the foregoing Paragraph 7.3.

         7.5 In the event that the declaratory judgment action or any other
action alleging invalidity, unenforceability, or non-infringement of any of the
PATENT RIGHTS shall be brought, VIACELL or GENERAL shall promptly notify the
other party. VIACELL shall have the sole right to defend such action at its own
expense, unless GENERAL, within thirty (30) days after notification of such
action, elects to intervene and take over the sole defense of the action at its
own expense.

         7.6 VIACELL may offset a total of fifty percent (50%) of expenses
incurred by it pursuant to this Article 7 against any amounts payable to GENERAL
under Article 5, provided, however, that in no event shall amount due GENERAL
under Article 5 be reduced by more than fifty percent (50%) in any ACCOUNTING
PERIOD, and provided, further, any reduction hereunder, or portion thereof, that
is rendered not usable pursuant to the immediately preceding proviso may be
carried forward for use in a future ACCOUNTING PERIOD. For clarity, in the event
that VIACELL offsets its expenses pursuant to this Article 7 as well as royalty
payments due to third parties under Paragraph 5.1(c), the combined offsets shall
not reduce amounts due GENERAL under Article 5 by more than fifty percent (50%)
in any ACCOUNTING PERIOD.

                               8. INDEMNIFICATION

                                       12

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
         8.1 (a) VIACELL shall indemnify, defend and hold harmless GENERAL and
its trustees, officers, medical and professional staff, employees, and agents
and their respective successors, heirs and assigns (the "MGH INDEMNITEES"),
against any liability, damage, loss or expense (including reasonable attorney's
fees and expenses of litigation) incurred by or imposed upon the MGH INDEMNITEES
or any one of them in connection with any claims, suits, actions, demands or
judgments arising out of any theory of product liability (including, but not
limited to, actions in the form of tort, warranty, or strict liability)
concerning any product, process or service, made, used or sold pursuant to any
right or license granted under this Agreement.

               (b) VIACELL's indemnification under (a) above shall not apply to
any liability, damage, loss or expense that it is directly attributable to the
negligent activities, reckless misconduct or intentional misconduct of the MGH
INDEMNITEES.

               (c) VIACELL agrees, at its own expense to provide attorneys
reasonable acceptable to GENERAL to defend against any actions brought or filed
against any MGH INDEMNITEES with respect to the subject of indemnity contained
herein, whether or not such actions are rightfully brought.

               (d) This paragraph 8.1 shall survive expiration or termination of
this Agreement.

         8.2 (a) HHMI and its trustees, officers, employees, and agents
(collectively, "HHMI INDEMNITEES", and together with the MGH INDEMNITEES, the
"INDEMNITEES") will be indemnified, defended by counsel reasonably acceptable to
HHMI and held harmless by VIACELL from and against any claim, liability, cost,
expense, damage, deficiency, loss, or obligation, of any kind or nature
(including, without limitation, reasonable attorneys' fees and other costs and
expenses of defense) (collectively, "CLAIMS"), based upon, arising out of, or
otherwise relating to this Agreement, including, without limitation, any cause
of action relating to product liability. The previous sentence will not apply to
any Claim that is determined with finality by a court of competent jurisdiction
to result solely from the gross negligence or willful misconduct of an HHMI
INDEMNITEE.

               (b) This Paragraph 8.2 shall survive expiration or termination of
this Agreement.

         8.3 (a) For the indemnification obligations of VIACELL contained in
Paragraphs 8.1 and 8.2 above, the following procedures shall apply: all
INDEMNITEES hereunder agree to provide VIACELL with prompt written notice of any
claim, suit, action, demand, or judgment for which indemnification is sought
under this Agreement. In the case of an HHMI INDEMNITEE, notice shall be given
reasonably promptly following actual receipt of written notice thereof by an
officer or attorney of HHMI. Notwithstanding the foregoing, the delay or failure
of an HHMI INDEMNITEE to give reasonably prompt notice to VIACELL of any such
claim shall not affect the rights of such HHMI INDEMNITEE unless, and then only
to the extent

                                       13

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
that, such delay or failure is prejudicial to or otherwise adversely affects
VIACELL. VIACELL agrees, at its own expense, to provide attorneys reasonably
acceptable to the applicable INDEMNITEES to defend against any such claim. The
applicable INDEMNITEES shall cooperate fully with VIACELL in such defense and
will permit VIACELL to conduct and control such defense and the disposition of
such claims, suit, or action (including, without limitation, all decisions
relative to litigation, appeal, and settlement; provided, however, that any
INDEMNITEE shall have the right to retain its own counsel, at the expense of
VIACELL, if representation of such INDEMNITEE by the counsel retained by VIACELL
would be inappropriate because of actual or potential differences in the
interests of such INDEMNITEE and any other party represented by such counsel.
VIACELL agrees not to settle any CLAIM against an HHMI INDEMNITEE without HHMI's
written consent, where (a) such settlement would include any admission of
liability on the part of any HHMI INDEMNITEE, (b) such settlement would impose
any restriction on any HHMI INDEMNITEE's conduct of any of its activities, or
(c) such settlement would not include an unconditional release of all HHMI
INDEMNITEES from all liability for claims that are the subject matter of the
settled CLAIM. VIACELL agrees to keep GENERAL and HHMI, as the case may be,
informed of the progress in the defense and disposition of any such claim.

               (b) This Paragraph 8.3 shall survive expiration or termination of
this Agreement.

         8.4 (a) Beginning at such time as any LICENSED PRODUCT is being
commercially distributed or sold for use in the LICENSED FIELD (other than for
the purpose of obtaining regulatory approvals) by VIACELL or by a SUBLICENSEE,
AFFILIATE or agent of VIACELL, VIACELL shall, at its sole cost and expense,
procure and maintain commercial general liability insurance in amounts not less
than $2,000,000 per incident and $2,000,000 annual aggregate and naming the
INDEMNITEES as additional insureds. Such commercial general liability insurance
shall prove (i) product liability coverage and (ii) broad form contractual
liability coverage for VIACELL's indemnification under Paragraphs 8.1 and 8.2 of
this Agreement. If VIACELL elects to self-insure all or part of the limits
described above (including deductibles or retentions which are in excess of
$250,000 annual aggregate) such self-insurance program must be reasonably
acceptable to GENERAL and the Risk Management Foundation. The minimum amounts of
insurance coverage required under this Paragraph 8.3 shall not be construed to
create a limit of VIACELL's liability with respect to its indemnification under
Paragraphs 8.1 and 8.2 of this Agreement.

               (b) VIACELL shall provide GENERAL with written evidence of such
insurance upon request of GENERAL. VIACELL shall provide GENERAL with written
notice at least fifteen (15) days prior to the cancellation, non-renewal or
material change in such insurance; if VIACELL does not obtain replacement
insurance providing comparable coverage prior to the expiration of such fifteen
(15) day period, GENERAL shall have the right to terminate this Agreement
effective at the end of such fifteen (15) day period without notice or any
additional waiting periods.

                                       14

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
               (c) VIACELL shall maintain such commercial general liability
insurance beyond the expiration or termination of this Agreement during (i) the
period that any LICENSED PRODUCT is being commercially distributed or sold for
use in the LICENSED FIELD (other than for the purpose of obtaining regulatory
approvals) by VIACELL or by a SUBLICENSEE, AFFILIATE or agent of VIACELL and
(ii) a reasonable period after the period referred to in (c)(i) above which in
no event shall be less than fifteen (15) years.

               (d) This Paragraph 8.4 shall survive expiration or termination of
this Agreement.

         8.5 OTHER THAN REPRESENTATIONS AND WARRANTIES SET FORTH HEREIN
(INCLUDING, WITHOUT LIMITATION, THE PREAMBLES), GENERAL MAKES NO REPRESENTATION
OR WARRANTY, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED
WARRANTY OF MERCHANTABILITY OR ANY IMPLIED WARRANTY OF FITNESS FOR A PARTICULAR
PURPOSE WITH RESPECT TO ANY PATENT, KNOW-HOW, TRADEMARK SOFTWARE, TRADE SECRET,
TANGIBLE RESEARCH PROPERTY, INFORMATION OR DATA LICENSED OR OTHERWISE PROVIDED
TO VIACELL HEREUNDER AND HEREBY DISCLAIMS THE SAME.

         8.6 UNDER NO CIRCUMSTANCES SHALL EITHER PARTY BE ENTITLED TO RECOVER
FROM THE OTHER ANY INCIDENTAL, CONSEQUENTIAL, INDIRECT, SPECIAL, EXEMPLARY OR
PUNITIVE DAMAGES; provided, however, that this Paragraph 8.6 shall in no way
reduce or limit VIACELL's obligations under the foregoing Paragraphs 8.1 and
8.2. This Paragraph 8.6 shall survive expiration or termination of this
Agreement.

         8.7 GENERAL represents that, to the best of its knowledge as of the
EFFECTIVE DATE, there are no contractual obligations to other sponsors of
research at GENERAL that would prohibit the granting of the rights and licenses
granted to VIACELL herein.

         8.8 HHMI is not a party to this Agreement and has no liability to any
licensee, sublicensee, or user of anything covered by this Agreement, but HHMI
is an intended third-party beneficiary of this Agreement and certain of its
provisions are for the benefit of HHMI and are enforceable by HHMI in its own
name. This Paragraph 8.8 shall survive expiration or termination of this
Agreement.

                                 9. TERMINATION

         9.1 Unless otherwise terminated as provided for in this Agreement, the
license to PATENT RIGHTS granted hereunder will continue on a country by country
basis:

               (a) for one (1) year after the date VIACELL, its AFFILIATES, or
SUBLICENSEES shall last sell any PRODUCT in such country, it being understood
that

                                       15

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
GENERAL shall have the right to notify VIACELL in accordance with the
termination provisions contained in Paragraph 9.3 so as to terminate such
license in any country in the event that after the FIRST COMMERCIAL SALE of
PRODUCT in such country there is a continuous one (1) year period in which no
PRODUCT is sold in such country, provided such sale is not prevented by force
majeure, government regulation or intervention, or institution of a lawsuit by
any third party, or

               (b) until the last to expire of any PATENT RIGHT, the claims of
which but for this Agreement would be infringed by the manufacture, use or sale
of any PRODUCT in the applicable country, whichever shall first occur.

         9.2 VIACELL may terminate this Agreement at any time upon written
notice to GENERAL following completion of the INITIAL OBJECTIVES.

         9.3 If either party shall fail to faithfully perform any of its
obligations under this Agreement except the due-diligence milestones specified
in Article 3 herein, the non-defaulting party may give written notice of the
default to the defaulting party specifying in reasonable detail the default. The
parties shall thereafter consult concerning the alleged default, and unless such
default is corrected within forty-five (45) days after such notice, the
notifying party may terminate this Agreement and the license hereunder upon
forty-five (45) days prior written notice, provided that only one such
forty-five (45) day grace period shall be available in any twelve (12) month
period with respect to a default of any particular provision hereunder.
Thereafter notice of default of said provision shall constitute termination.

         9.4 In the event that any license granted to VIACELL under this
Agreement is terminated, any sublicense under such license granted prior to
termination of said license shall remain in full force and effect, provided
that:

               (a) the SUBLICENSEE is not then in breach of its sublicense
agreement;

               (b) the SUBLICENSEE agrees to be bound to GENERAL as the licensor
under the terms and conditions of its sublicense agreement, as modified by the
provisions of this Paragraph 9.3;

               (c) the SUBLICENSEE, at GENERAL's written request, assumes in a
signed writing the same obligations to GENERAL as those assumed by VIACELL under
Articles 8 and 10 hereof;

               (d) GENERAL shall have the right to receive the greater of (a)
any payments payable to VIACELL under such sublicense agreement to the extent
they are reasonably and equitably attributable to such SUBLICENSEE's right under
such sublicense to use and exploit PATENT RIGHTS and KNOW-HOW or (b) the lowest
royalty which is within the "Competitive" range as hereinafter defined, at the
time GENERAL's license to VIACELL is terminated. A royalty rate shall be
regarded as "Competitive" if it is within the range of royalty

                                       16

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
rates that GENERAL would charge in an arm's length transaction with a licensee
which was not and had not been a sponsor of research at GENERAL, taking into
account the value of the licensed technology at the time GENERAL's license to
VIACELL is terminated;

               (e) the SUBLICENSEE agrees to be bound by the due diligence
obligations of VIACELL pursuant to Paragraph 3.1 hereof (whether set by the
parties or by Alternate Dispute Resolution pursuant to Paragraph 10.10) in the
field and territory of the sublicense;

               (f) GENERAL has the right to terminate such sublicense upon
fifteen (15) days prior written notice to VIACELL and such SUBLICENSEE in the
event of any material breach of the obligation to make the payments described in
clause (d) of this Paragraph 9.4, unless such breach is cured prior to the
expiration of such fifteen (15) day period, and shall further have the right to
terminate such sublicense in the event of SUBLICENSEE's failure to meet its due
diligence obligations pursuant to clause (e) of this Paragraph 9.4;

               (g) GENERAL shall not assume, and shall not be responsible to
such SUBLICENSEE for, any representations, warranties or obligations of VIACELL
to such SUBLICENSEE, other than to permit such SUBLICENSEE to exercise any
rights to PATENT RIGHTS and KNOW-HOW that are granted under such sublicense
agreement consistent with the terms of this Agreement.

         9.5 Upon termination of any license hereunder VIACELL shall pay GENERAL
all royalties due or accrued on (i) the sale of PRODUCT up to and including the
date of termination and (ii) for twelve (12) months following the date of
termination, the sale of PRODUCT manufactured prior to the termination date.

                               10. MISCELLANEOUS

         10.1 This Agreement constitutes the entire understanding between the
parties with respect to the subject matter hereof and supersedes all prior
agreements and understandings between the parties pertaining to the subject
matter hereof.

         10.2 In order to facilitate implementation of this Agreement, GENERAL
and VIACELL are designating the following individuals to act on their behalf
with respect to this Agreement for the matter indicated below:

               (a) with respect to all royalty payments, any correspondence
pertaining to any PATENT RIGHT, or any notice of the use of GENERAL's name, for
GENERAL, the Director, Corporate Sponsored Research and Licensing and for
VIACELL, Director, Business Development, ViaCell, Inc., One Innovation Drive,
Worcester, Massachusetts 01605, with a copy to Senior Vice-President of Business
Development, ViaCell, Inc., 131 Clarendon Street, Boston, Massachusetts 02116;
provided that correspondence relating to the billing of patent costs shall also
be copied to, for GENERAL, the Business Manager, Corporate Sponsored Research
and Licensing.

                                       17

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
               (b) any amendment of or waiver under this Agreement, any written
notice (including, without limitation, progress reports or other communication
pertaining to the Agreement): for GENERAL, the Director, Corporate Sponsored
Research and Licensing; and for VIACELL, Director, Business Development,
ViaCell, Inc., One Innovation Drive, Worcester, Massachusetts 01605, with a copy
to Senior Vice-President of Business Development, ViaCell, Inc., 131 Clarendon
Street, Boston, Massachusetts 02116.

               (c) the above designations may be superseded from time to time by
alternative designations made by: for GENERAL, the Vice President for Corporate
Sponsored Research and Licensing and for VIACELL, Director, Business
Development, ViaCell, Inc., One Innovation Drive, Worcester, Massachusetts
01605.

         Any notices required or permitted under this Agreement shall be in
writing, shall specifically refer to this Agreement, and shall be sent by hand,
recognized national overnight courier, or registered or certified mail, postage
prepaid, return receipt requested, to the appropriate addresses specified above,
and shall be effective upon receipt.

         10.3 This Agreement may be amended and any of its terms or conditions
may be waived only by a written instrument executed by the parties or, in the
case of a waiver, by the party waiving compliance. The failure of either party
at any time or times to require performance of any provision hereof shall in no
manner affect its rights at a later time to enforce the same. No waiver by
either party of any condition shall be deemed as a further or continuing waiver
of such condition or term or of any other condition or term.

         10.4 This Agreement shall be binding upon and inure to the benefit of
and be enforceable by the parties hereto and their respective legal
representatives, successors and permitted assigns.

         10.5 Any delays in or failures of performance by either party under
this Agreement shall not be considered a breach of this Agreement if and to the
extent caused by occurrences beyond the reasonable control of the party
affected, including but not limited to: Acts of God; acts, regulations or laws
of any government; strikes or their concerted acts of worker; fires; floods;
explosions; riots, wars; rebellion; action, inaction or delay by any
governmental authority; bankruptcy of third parties; and sabotage. Any time for
performance hereunder shall be extended by the actual time or delay caused by
such occurrence.

         10.6 Neither party shall use the name of the other party of any staff
member, officer, employee or student of the other party or any adaptation
thereof in any advertising, promotional or sales literature, publicity or in any
document employed to obtain funds or financing without the prior written
approval of the party or individual whose name is to be used. For GENERAL, such
approval shall be obtained from the Director of Public Affairs.

         10.7 This Agreement shall be governed by and construed and interpreted
in accordance with the laws of the Commonwealth of Massachusetts without regard
to conflicts of laws

                                       18

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
principles, except that questions concerning the validity, enforceability,
construction or effect of any PATENT RIGHTS shall be determined by the law of
the country in which such PATENT RIGHT shall have been granted.

         10.8 This Agreement shall not be assignable by GENERAL without
VIACELL's written consent except for the right to receive royalties or other
payments payable herein. VIACELL may at its own discretion and without approval
by GENERAL transfer its interest or any part thereof under this Agreement to its
parent corporation or an AFFILIATE in the event VIACELL is dissolved following
completion of the INITIAL OBJECTIVES, or, in the event of merger, consolidation
or sale of substantially all of VIACELL's assets or that portion of VIACELL's
business to which this Agreement relates, to the purchaser or assignee of said
assets or to the surviving entity in any merger, consolidation or acquisition.
In the event of any such transfer, the transferee shall assume and be bound by
the provisions of this Agreement. Otherwise this Agreement shall be assignable
by VIACELL only with the consent in writing of GENERAL.

         10.9 In the event VIACELL becomes independent from its parent
corporation (i.e., establishes a separate ownership structure from ViaCell,
Inc.), VIACELL and GENERAL may elect to renegotiate the terms of this Agreement
to achieve a structure and terms more suitable to VIACELL as an independent
entity.

         10.10 For any and all claims, disputes, or controversies arising under,
out of, or in connection with this Agreement, except claims, disputes, or
controversies affecting the rights or property of HHMI or the validity,
enforceability, construction, or effect of any PATENT RIGHT, which the parties
shall be unable to resolve within sixty (60) days, the party raising such
dispute shall promptly advise the other party of such claim, dispute, or
controversy in a writing which describes in reasonable detail the nature of such
dispute. By not later than five (5) business days after the recipient has
received such notice of dispute, each party shall have selected for itself a
representative who shall have the authority to bind such party and shall
additionally have advised the other party in writing of the name and title of
such representative. By not later than ten (10) business days after the date of
such notice of dispute, such representatives shall agree upon a third party
which is in the business of providing Alternative Dispute Resolution (ADR)
services (hereinafter, "ADR Provider") and shall schedule a date with such ADR
Provider to engage in ADR. Thereafter, the representatives of the parties shall
engage in good faith in an ADR process under the auspices of the selected ADR
Provider. If within the aforesaid thirty (30) business days after the date of
the notice of dispute the representatives of the parties have not been able to
agree upon an ADR Provider and schedule a date to engage in ADR, or if they have
not been able to resolve the dispute within thirty (30) business days after the
termination of ADR, the parties shall have the right to pursue any other
remedies legally available to resolve such dispute in either the Courts of the
Commonwealth of Massachusetts or in the United States District Court for the
District of Massachusetts, to whose jurisdiction for such purposes each of
GENERAL and VIACELL hereby irrevocably consents and submits (except for any
matters which may not be heard in any such courts because it lacks subject
matter jurisdiction, which matters may be heard in the appropriate judicial
forum).

                                       19

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
Notwithstanding the foregoing, nothing in this Paragraph 10.10 shall be
construed to waive any rights or timely performance of any obligations existing
under this Agreement.

         10.11 If any provision(s) of this Agreement are or become invalid, are
ruled illegal by any court of competent jurisdiction or are deemed unenforceable
under then current applicable law from time to time in effect during the term
hereof, it is the intention of the parties that the remainder of this agreement
shall not be effected thereby. It is further the intention of the parties that
in lieu of each such provision which is invalid, illegal or unenforceable, there
be substituted or added as part of this Agreement a provision which shall be as
similar as possible in economic and business objectives as intended by the
parties to such invalid, illegal or enforceable provision, but shall be valid,
legal and enforceable.

         10.12 The captions herein have been inserted solely for convenience of
reference and in no way define or limit the scope or substance of any provision
of this Agreement. As used in this Agreement, "herein" and "hereof" shall refer
to this Agreement as a whole. Facsimile execution and delivery of this Agreement
by either party shall be legal, valid and binding.

                                     ******

                                       20

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.

<PAGE>
         THE PARTIES have duly executed this Agreement as of the date first
shown above written.

VIACELL, INC.                           THE GENERAL HOSPITAL CORPORATION

BY: Signature on File                   BY: Signature on File
    ------------------------------          -------------------------------

TITLE: Senior Vice President            TITLE: Director
       ---------------------------             ----------------------------

DATE: 3/15/02                           DATE: 3/15/02
      ----------------------------                   ----------------------

                                       21

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
                                   APPENDIX A

                                  PATENT RIGHTS

                                     MGH [*]

                                       22

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
                                   APPENDIX B

                               INITIAL OBJECTIVES

1.   CHARACTERIZE NESTIN POSITIVE ISLET DERIVED STEM CELLS AT THE MOLECULAR
     LEVEL:

     VIACELL will conduct research to identify and isolate nestin positive
     islet derived stem/progenitor cells (NIPs) using specific markers and
     characterize them at the molecular level.

2.   ESTABLISH A PRE CLINICAL ANIMAL MODEL OF DIABETES MELLITUS:

     VIACELL will establish an appropriate pre clinical model for cellular
     replacement of islet precursors as a treatment mode for diabetes
     mellitus (DM). The optional model will be established by evaluating
     several potential animal models using NIPs obtained from different
     sources, following different graft preparations, routes of administration,
     timing of transplant, etc. Relevant models which may be evaluated include:
     streptozotocin induced diabetes mice and rats, and Type 1 in NOD and or
     NOD/SCID mice.

3.   DESIGN & PERFORM EXPERIMENTS TO DEMONSTRATE EFFICACY IN AN ANIMAL MODEL:

     VIACELL will design and complete experiments with the objective of
     demonstrating proof of optional (i.e., efficacy) for human derived, or a
     corollary to human derived, NIPs as a treatment for DM in the
     establishment pre clinical animal model.

                                       23

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
                                   APPENDIX C

                             PERFORMANCE OBJECTIVES

              (TO BE DEVISED UPON COMPLETION OF INITIAL OBJECTIVES)

                                       24

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.
<PAGE>
                                   APPENDIX D

                               NON-PUBLIC KNOW-HOW

                      (TO BE COMPLETED BY DR. JOEL HABENER)

* Confidential treatment has been requested with respect to certain portions of
this exhibit. Such portions are marked with a "[*]" in place of the redacted
language. Omitted portions are filed separately with the Securities and Exchange
Commission.

                                       25<PAGE>

                                                                    Exhibit 10.1

                                  EGENERA, INC.

                              AMENDED AND RESTATED
                      2000 STOCK OPTION/STOCK ISSUANCE PLAN

     1.   Purpose. This 2000 Stock Option/Stock Issuance Plan (the "Plan") is
intended to promote the interests of Egenera, Inc. by giving incentives to the
eligible officers and other employees and directors of and consultants and
advisors to Egenera, Inc. (the "Company"), its parent (if any) and any present
or future subsidiaries of the Company (collectively, "Related Corporations")
through providing opportunities to acquire stock in the Company. As used herein,
the terms "parent" and "subsidiary" mean "parent corporation" and "subsidiary
corporation", respectively, as those terms are defined in Sections 424(e) and
424(f) or successor provisions of the Internal Revenue Code of 1986 as amended
from time to time (the "Code").

     2.   Structure of the Plan. The Plan permits the following separate types
of grant:

     A. Options may be granted hereunder to purchase shares of common stock of
the Company. These options may meet the requirements of Section 422 of the Code
("Incentive Stock Options" or "ISOs"); or, they may not qualify as ISOs
("Non-Qualified Options"). Both ISOs and Non-Qualified Options are sometimes
referred to hereinafter as "Options".

     B. Awards of stock in the Company ("Awards") may be granted.

     C. Opportunities to make direct purchases of stock in the Company
("Purchases") may be authorized.

Options, Awards and authorizations to make Purchases are sometimes referred to
hereinafter as "Stock Rights".

     3.   Administration of the Plan.

     A. The Plan shall be administered by the Board of Directors of the Company
(the "Board"). The Board may in its sole discretion grant Options, authorize
Purchases and grant Awards, as provided in the Plan. The Board shall have full
power and authority, subject to the express provisions of the Plan, to construe
and interpret the Plan and all Option agreements, Purchase authorizations and
Award grants thereunder, to establish, amend and rescind such rules and
regulations as it may deem appropriate for the proper administration of the
Plan, to determine in each case the terms and provisions which shall apply to a
particular Option agreement, Purchase authorization, or Award grant, and to make
all other determinations which are, in the Board's judgment, necessary or
desirable for the proper administration of the Plan. The Board may correct any
defect, supply any omission or reconcile any inconsistency in the Plan or in any
Option agreement, Purchase authorization or Award grant in the manner and to the
extent it shall, in its sole discretion, consider expedient. Decisions of the
Board shall be final and

<PAGE>

binding on all parties who have an interest in the Plan or any Option, Purchase,
Award, or stock issuance thereunder. No director or person acting pursuant to
authority delegated by the Board shall be liable for any action or determination
under the Plan made in good faith.

     B. The Board may, to the full extent permitted by and consistent with
applicable law and the Company's By-laws, and subject to Subparagraph D
hereinbelow, delegate any or all of its powers with respect to the
administration of the Plan to a committee (the "Committee") appointed by the
Board. If a Committee has been appointed, all references in this Plan to the
Board shall mean and relate to that Committee.

     C. Those provisions of this Plan which make express reference to Rule 16b-3
under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or
any successor rule ("Rule 16b-3"), or which are required in order for certain
option transactions to qualify for exemption under Rule 16b-3, shall apply only
to those persons required to file reports under Section 16(a) of the Exchange
Act (a "Reporting Person").

     D. If the Company registers any class of equity security under Section 12
of the Exchange Act, the selection of a director or an officer (as the terms
"director" and "officer" are defined for purposes of Rule 16b-3) as a recipient
of an option, the timing of the option grant, the exercise price of the option
and the number of shares subject to the option shall be determined either (i) by
the Board, if all of the Board members are disinterested persons within the
meaning of Rule 16(b)(3), or (ii) by two or more directors having full authority
to act in the matter, each of whom shall be such a disinterested person.

     4.   Eligible Employees and Others. ISOs may be granted to any employee of
the Company or of any Related Corporation. No person who is not such an employee
may be granted an ISO. Non-Qualified Options, Awards, and authorizations to make
Purchases may be granted to any employee, officer or director of, or consultant
or advisor to the Company or any Related Corporation. The granting of any Stock
Right to any individual or entity shall neither entitle that individual or
entity to, nor disqualify him from, participation in any other grant of Stock
Rights.

     5.   Stock. The stock subject to Options, Awards and Purchases shall be
authorized but unissued shares of common stock of the Company ("Common Stock"),
or shares of Common Stock reacquired by the Company in any manner. Subject to
adjustment as provided in Paragraph 14, the aggregate number of shares that may
be issued under the Plan is 15,250,000 shares of Common Stock. In no event shall
the number of shares subject to all Options, Awards or Purchases under the Plan
at the time of the grant of, and including the shares subject to, any Option,
Award or Purchase exceed 15,250,000 shares of Common Stock (as adjusted pursuant
to Paragraph 14) (a) less (i) the number of shares then subject to options
granted pursuant to the Company's 2001 California Stock Option/Stock Issuance
Plan (the "California Plan") and (ii) without duplication of any shares
described in the foregoing clause (i), the number of shares previously issued
pursuant to the exercise of any option granted, or award or purchase under the
California Plan, (b) plus the number of shares originally issued pursuant to the
exercise of any option granted, or award or purchase under the California Plan
or this Plan that are repurchased by the Company pursuant to contractual rights
held by the Company and at repurchase prices not

                                                                               2
<PAGE>

exceeding the respective original purchase prices (or fair market value of such
shares as approved by the Board of Directors) paid by such persons to the
Company. If any option granted under the Plan or under the California Plan shall
expire or terminate for any reason without having been exercised in full or
shall cease for any reason to be exercisable in whole or in part, the
unpurchased shares subject to such Option or option shall again be available for
grants of Stock Rights under the Plan.

     6.   Option Agreements. As a condition to the grant of an Option, each
recipient of an Option shall execute an option agreement in such form not
inconsistent with the Plan as the Board shall approve. These option agreements
may differ among recipients. Each option agreement with respect to an ISO shall
be subject to the provisions of the Plan applicable to ISOs. The Board may, in
its sole discretion, include additional provisions in option agreements,
including without limitation restrictions on transfer, repurchase rights,
commitments to pay cash bonuses, to make, arrange for or guarantee loans or to
transfer other property to optionees upon exercise of options, or such other
provisions as shall be determined by the Board; provided, however, that such
additional provisions shall not be inconsistent with any provision of the Plan
and such additional provisions shall not cause any ISO granted under the Plan to
fail to qualify as an incentive stock option within the meaning of Section 422
of the Code.

     7.   Option Exercise Price.

     A. Subject to Subparagraph 3D of this Plan and Subparagraphs B and C of
this Paragraph 7, the purchase price per share of Common Stock deliverable upon
the exercise of an Option ("exercise price") shall be determined by the Board.

     B. In the case of an ISO, the exercise price shall not be less than 100% of
the fair market value of Common Stock, as determined by the Board, at the time
of grant of such option, or less than 110% of such fair market value in the case
of an ISO granted to the owner of stock possessing more than 10% of the total
combined voting power of all classes of stock of the Company or any Related
Corporation (after taking into account the attribution of stock ownership rules
of Section 424(d) of the Code) (a " 10% Shareholder").

     C. The exercise price of each Non-Qualified Option granted under the Plan
shall in no event be less than the lesser of (i) the book value per share of
Common Stock as of the end of the fiscal year of the Company immediately
preceding the date of grant, or (ii) thirty percent (30%) of the fair market
value per share of Common Stock on the date of grant.

     8.   Cancellation and New Grant of Options, Etc. The Board shall have the
authority to effect, at any time and from time to time, with the consent of the
affected optionees, (i) the cancellation of any or all outstanding Options and
the grant in substitution therefor of new Options covering the same or different
shares of Common Stock and having an exercise price per share which may be lower
or higher than the exercise price per share of the canceled Options, or (ii) the
amendment of the terms of any and all outstanding Options to provide an exercise
price per share which is higher or lower than the then-current exercise price
per share of such outstanding Options.

                                                                               3
<PAGE>

     9.   Exercise of Options.

     A. Each Option granted under the Plan shall be exercisable either in full
or in installments at such time or times and during such period as shall be set
forth in the agreement evidencing the Option, subject to the provisions of the
Plan. An option agreement may permit the Option granted thereunder to be
exercised before it is vested (an "Early Exercise"), subject to the Company's
right of repurchase, under a Stock Restriction Agreement (as defined below) to
be executed by the option holder and the Company at the time of such Early
Exercise, over any shares acquired under the unvested portion of the Option,
which right of repurchase shall lapse at the same time the Option would have
vested had there been no Early Exercise. Unless doing so would have the effect
of causing an ISO to be treated as a Non-Qualified Option, the board may, in its
sole discretion, after consideration of such factors as it considers relevant
(which may include the impact, if any, on the Company's financial statements of
such change in the terms of the Option or Options), (i) accelerate the date or
dates on which all or any particular Option or Options granted under the Plan
may be exercised or (ii) extend the dates during which all, or any particular,
Option or Options granted under the plan may be exercised.

     B. Options granted under the Plan may provide for payment of the exercise
price by delivery of cash or a check payable to the order of the Company, or, to
the extent (if at all) provided in the option agreement: (i) by delivery to the
Company of shares of Common Stock of the Company already owned by the optionee
having a fair market value determined by the Board to be equal in amount to the
exercise price of the Options being exercised, or (ii) by delivery of a recourse
promissory note of the optionee bearing interest payable not less than annually
at the applicable Federal rate as defined in Section 1274(d) of the Code and
otherwise payable on such terms as are specified by the Board, or (iii) by
requesting that the Company withhold shares of Common Stock of the Company
issuable upon exercise of the Options having a fair market value determined by
the Board to be equal in amount to the exercise price of the Options being
exercised, or (iv) by any combination of the above methods of payment.

     10.  Option Period. Subject to earlier termination under other provisions
of this Plan, each Option and all rights thereunder shall expire on such date as
shall be set forth in the applicable option agreement, except that, in the case
of an ISO, such expiration date shall not be later than ten years after the date
on which the ISO is granted and, in the case of an ISO granted to a 10%
Shareholder as defined in Subparagraph 7B of this Plan, such expiration date
shall not be later than five years after the date on which the ISO is granted.

     11.  Nontransferability of Options. Options shall not be assignable or
transferable by the optionee, either voluntarily or by operation of law, except
by will or the laws of descent and distribution, and, during the life of the
optionee, shall be exercisable only by the optionee.

     12.  Effect of Termination of Employment or Other Relationship. Except as
otherwise provided in Paragraph 10 and Subparagraph 13C with respect to ISOs,
and subject to all other provisions of the Plan, the Board shall determine the
period of time during which an optionee may exercise an Option following (i) the
termination of the optionee's employment or other relationship with the Company
or a Related Corporation or (ii) the death or disability of the optionee. Such
periods shall be set forth in the agreement evidencing the Option.

                                                                               4
<PAGE>

     13.  Additional ISO Requirements. ISOs granted under the Plan are subject
to the minimum exercise price rules set forth in Subparagraph 7B hereof, the
option period rules of Paragraph 10 hereof, and various other restrictions set
forth elsewhere in this Plan. In addition, ISOs granted under the Plan are
subject to the following:

     A . Each ISO granted under the Plan shall, at the time of grant, be
specifically designated as such in the option agreement evidencing such Option.

     B. In no event shall the aggregate fair market value (determined at the
time an ISO is granted) of Common Stock for which ISOs granted to any employee
are exercisable for the first time by such employee during any calendar year
(under all stock option plans of the Company and any Related Corporation) exceed
One Hundred Thousand Dollars ($100,000); provided, however, that this
Subparagraph B shall have no force or effect if its inclusion in the Plan is not
necessary for Options issued as ISOs to qualify as incentive stock options
within the meaning of Section 422 of the Code.

     C. No ISO may be exercised unless, at the time of such exercise, the
optionee is, and has been continuously since the date of grant of the ISO,
employed by the Company or a Related Corporation, except that:

          (i)  An ISO may be exercised within the period of three (3) months
     after the date the optionee ceases to be an employee of the Company and any
     Related Corporation (or within such lesser period as may be specified in
     the option agreement); provided, however, that the option agreement may
     designate a longer exercise period, in which case the exercise after such
     three-month period shall be treated as the exercise of a Non-Qualified
     Option.

          (ii) If the optionee dies while in the employ of the Company or a
     Related Corporation, or within three (3) months after the optionee ceases
     to be such an employee of the Company or a Related Corporation, the ISO may
     be exercised by the person to whom it is transferred by will or the laws of
     descent and distribution within the period of one (1) year after the date
     of death (or within such lesser period as may be specified in the option
     agreement).

          (iii) If the optionee becomes disabled (within the meaning of Section
     22(e)(3) of the Code) while in the employ of the Company or a Related
     Corporation, the ISO may be exercised within the period of one (1) year
     after the date the optionee's employment ceases because of such disability
     (or within such lesser period as may be specified in the option agreement).

For all purposes of the Plan and any agreement evidencing an Option,
"employment" shall be defined in accordance with the provisions of Treasury
Regulation Section 1.421-7(h) under the Code (or any successor regulations).
Notwithstanding the foregoing provisions, no ISO may be exercised after its
expiration date.

                                                                               5
<PAGE>

     14.  Adjustments.

     A. If, through or as a result of any merger, consolidation, sale of all or
substantially all of the assets of the Company, reorganization,
recapitalization, reclassification, stock dividend, stock split, reverse stock
split or other similar transaction, (i) the outstanding shares of Common Stock
are increased, decreased or exchanged for a different number or kind of shares
or other securities of the Company, or (ii) additional shares or new or
different shares or other securities of the Company or other non-cash assets are
distributed with respect to such shares of Common Stock or other securities, an
appropriate and proportionate adjustment shall be made in (a) the maximum number
and kind of shares reserved for issuance under the Plan, (b) the number and kind
of shares or other securities subject to any then outstanding Options under the
Plan, and (c) the price for each share subject to any then outstanding Options
under the Plan, without changing the aggregate purchase price as to which such
Options remain exercisable. No fractional shares shall be issued under the Plan
on account of any such adjustments. Notwithstanding the foregoing provisions of
this Subparagraph A, no adjustment shall be made pursuant to this Paragraph 14
if such adjustment would cause any ISO granted under the Plan to fail to qualify
as an incentive stock option within the meaning of Section 422 of the Code.

     B. Any adjustments under this Paragraph 14 shall be made by the Board of
Directors, whose determination as to what adjustments, if any, will be made and
the extent thereof shall be final, binding and conclusive.

     15.  Rights as a Shareholder. The holder of an Option shall have no rights
as a shareholder with respect to any shares covered by the option (including,
without limitation, any voting rights, or any rights to receive dividends or
non-cash distributions with respect to such shares) until the date of issue of a
stock certificate for such shares. No adjustment shall be made for dividends or
other rights for which the record date is prior to the date such stock
certificate is issued.

     16.  Merger, Consolidation. Asset Sale, Liquidation. etc.

     A. Except as may otherwise be provided in the applicable option agreement,
in the event of a consolidation or merger or sale of all or substantially all of
the assets of the Company in which outstanding shares of Common Stock are
exchanged for securities, cash or other property of any other corporation or
business entity, or in the event of the liquidation of the Company, the Board,
or the board of directors of any corporation assuming the obligations of the
Company, shall, in its discretion, take any one or more of the following
actions, as to outstanding Options: (i) provide that such Options shall be
assumed, or equivalent options shall be substituted, by the acquiring or
succeeding corporation (or an affiliate thereof), provided, however, that any
such Options substituted for ISOs shall meet the requirements of Section 424(a)
of the Code; (ii) upon written notice to the optionees, provide that any and all
outstanding Options shall become exercisable in full (to the extent not
otherwise so exercisable) as of a specified date or time ("Accelerated Vesting
Date") prior to the consummation of such transaction, and that all unexercised
Options shall terminate as of a specified date or time ("Accelerated Expiration
Date") following the Accelerated Vesting Date unless exercised by the optionee
prior to the Accelerated Expiration Date, provided, however, that optionees
shall be given a reasonable

                                                                               6
<PAGE>

period of time within which to exercise or provide for the exercise of
outstanding Options following such written notice and before the Accelerated
Expiration Date; (iii) in the event of a merger under the terms of which holders
of the Common Stock of the Company will receive upon consummation thereof a cash
payment for each share surrendered in the merger (the "Merger Price"), terminate
each outstanding Option in exchange for a payment, made or provided for by the
Company, equal in amount to the excess, if any, of the Merger Price over the
per-share exercise price of each such Option, times the number of shares of
Common Stock subject to such Option; or (iv) terminate each outstanding Option
in exchange for a cash payment equal in amount to the product of the excess, if
any, of the fair market value of a share of Common Stock over the per-share
exercise price of each such Option, times the number of shares subject to such
Option. The Board shall determine the fair market value of a share of Common
Stock for purposes of the foregoing, and the Board's determination of such fair
market value shall be final, binding and conclusive.

     B. The Company may grant Options under the Plan in substitution for Options
held by employees of another corporation who become employees of the Company or
a subsidiary of the corporation as the result of a merger or consolidation of
the employing corporation with the Company or a subsidiary of the Company, or as
a result of the acquisition by the Company or one of its subsidiaries of
property or stock of the employing corporation. The Company may direct that
substitute Options be granted on such terms and conditions as the Board
considers appropriate in the circumstances.

     17.  Stock Restriction Agreement. As a condition to the grant of an Award
or a Purchase authorization under the Plan, the recipient of the Award or
Purchase authorization shall execute an agreement ("Stock Restriction
Agreement") in such form not inconsistent with the Plan as may be approved by
the Board. Stock Restriction Agreements may differ among recipients. Stock
Restriction Agreements may include any provisions the Board determines should be
included and that are not inconsistent with any provision of the Plan.

     18.  No Special Employment Rights. Nothing contained in the Plan or in any
option agreement or other agreement or instrument executed pursuant to the
provisions of the Plan shall confer upon any optionee any right with respect to
the continuation of his or her employment by the Company or interfere in any way
with the right of the Company at any time to terminate such employment or to
increase or decrease the compensation of the optionee.

     19.  Other Employee Benefits. Except as to plans which by their terms
include such amounts as compensation, no amount of compensation deemed to be
received by an employee as a result of the grant or exercise of an Option or the
sale of shares received upon such exercise, or as a result of the grant of an
Award or the authorization or making of a Purchase will constitute compensation
with respect to which any other employee benefits of such employee are
determined, including, without limitation, benefits under any bonus, pension,
profit-sharing, life insurance or salary continuation plan, except as otherwise
specifically determined by the Board.

                                                                               7
<PAGE>

     20.  Amendment of the Plan.

     A. The Board may at any time, and from time to time, modify or amend the
Plan in any respect, except as otherwise expressly provided in this Plan;
provided, however, that if at any time the approval of the shareholders of the
Company is required under the Code with respect to ISOs, or is required under
Rule 16b-3, the Board may not effect such modification or amendment without such
approval.

     B. The termination or any modification or amendment of the Plan shall not,
without the consent of an optionee, affect the optionee's rights under an Option
previously granted. With the consent of the optionee affected, the Board may
amend outstanding option agreements in a manner not inconsistent with the Plan.
The Board shall have the right to amend or modify (i) the terms and provisions
of the Plan and of any outstanding ISO granted under the Plan to the extent
necessary to qualify any or all such Options for such favorable federal income
tax treatment (including deferral of taxation upon exercise) as may be afforded
incentive stock options within the meaning of Section 422 of the Code, and (ii)
the terms and provisions of the Plan and of any outstanding Option to the extent
necessary to ensure the qualification of the Plan under Rule 16b-3.

     21.  Investment Representations. The Board may require any person to whom
an Option is granted, as a condition of exercising such Option, and any person
to whom an Award is granted or a Purchase is authorized, as a condition thereof,
to give written assurances in substance and form satisfactory to the Board to
the effect that such person is acquiring the Common Stock subject to the Option,
Award or Purchase for such person's own account for investment and not with any
present intention of selling or otherwise distributing the same, and to such
other effects as the Company deems necessary or appropriate in order to comply
with federal and applicable state securities laws, or with covenants or
representations made by the Company in connection with any public offering of
its Common Stock.

     22.  Compliance With Securities Laws. Each Option shall be subject to the
requirement that if, at any time, counsel to the Company shall determine that
the listing, registration or qualification of the shares subject to such Option
upon any securities exchange or under any state or federal law, or the consent
or approval of any governmental or regulatory body, or that the disclosure of
non-public information or the satisfaction of any other condition is necessary
as a condition of, or in connection with, the issuance or purchase of shares
thereunder, such Option may not be exercised, in whole or in part, unless such
listing, registration, qualification, consent or approval, or satisfaction of
such condition shall have been effected or obtained on conditions acceptable to
the Board. Nothing herein shall be deemed to require the Company to apply for or
to obtain such listing, registration or qualification, or to satisfy such
condition.

     23.  Withholding. The Company shall have the right to deduct from payments
of any kind otherwise due to the optionee any federal, state or local taxes of
any kind required by law to be withheld with respect to any shares issued upon
exercise of Options under the Plan or upon the grant of an Award, the making of
a Purchase of Common Stock for less than its fair market value, the making of a
Disqualifying Disposition (as defined in Paragraph 24), or the vesting of

                                                                               8
<PAGE>

restricted Common Stock acquired pursuant to a Stock Right. The Board in its
sole discretion may condition the exercise of an Option, the grant of an Award,
the making of a Purchase, or the vesting of restricted shares acquired by
exercising a Stock Right on the grantee's payment of such additional withholding
taxes. Subject to the prior approval of the Company, which may be withheld by
the Company in its sole discretion, the grantee may elect to satisfy such
obligations, in whole or in part, (i) by causing the Company to withhold shares
of Common Stock otherwise issuable pursuant to the exercise of a Stock Right or
(ii) by delivering to the Company shares of Common Stock already owned by the
grantee. The shares so delivered or withheld shall have a fair market value
equal to such withholding obligation, and shall not be subject to any
repurchase, forfeiture, unfulfilled vesting or other similar requirements. The
fair market value of the shares used to satisfy such withholding obligation
shall be determined by the Company as of the date that the amount of tax to be
withheld is to be determined. Notwithstanding the foregoing, in the case of a
Reporting Person, no election to use shares for the payment of withholding taxes
shall be effective unless made in compliance with any applicable requirements of
Rule 16b-3 (unless it is intended that the transaction not qualify for exemption
under Rule 16b-3).

     24.  Notice to Company of Disqualifying Disposition. Each employee who
receives an ISO must agree to notify the Company in writing immediately after
the employee makes a Disqualifying Disposition, as hereinafter defined, of any
Common Stock acquired pursuant to the exercise of an ISO. A Disqualifying
Disposition is any disposition (including any sale) of such Common Stock before
the later of (a) two (2) years after the date the employee was granted the ISO
or (b) one (1) year after the date the employee acquired Common Stock by
exercising the ISO. If the employee has died before such stock is sold, these
holding period requirements do not apply and no Disqualifying Disposition can
occur thereafter.

     25.  Effective Date and Duration of the Plan.

     A. The Plan shall become effective when adopted by the Board, but no Stock
Right granted under the Plan shall become exercisable unless and until the Plan
shall have been approved by the Company's shareholders. If such shareholder
approval is not obtained within twelve months after the date of the Board's
adoption of the Plan, Stock Rights previously granted under the Plan shall not
vest and shall terminate and shall be null and void and no Stock Rights shall be
granted thereafter under the Plan. Amendments to the Plan not requiring
shareholder approval shall become effective when adopted by the Board;
amendments requiring shareholder approval shall become effective when adopted by
the Board, but no stock Right granted after the date of such amendment shall
become exercisable (to the extent that such amendment to the Plan was required
to enable the Company to grant such stock Right to a particular person) unless
and until such amendment shall have been approved by the Company's shareholders.
If such shareholder approval is not obtained within twelve months of the Board's
adoption of such amendment, any Stock Rights granted on or after the date of
such amendment shall terminate and become null and void to the extent that such
amendment was required to enable the Company to grant such Stock Rights to a
particular person. Subject to this limitation, Stock Rights may be granted under
the Plan at any time after the effective date and before the termination date of
the Plan.

                                                                               9
<PAGE>

     B. Unless sooner terminated as provided elsewhere in this Plan, this Plan
shall terminate upon the close of business on the day next preceding the tenth
anniversary of the date of its adoption by the Board. Stock Rights outstanding
on such date shall continue to have force and effect in accordance with the
provisions of the instruments evidencing such Stock Rights.

              Adopted by the Board of Directors on April 28, 2000.
              Amended and Restated on September 6, 2001.

                                                                              10
<PAGE>

                                 AMENDMENT NO. 1
                                       TO
                              AMENDED AND RESTATED
                      2000 STOCK OPTION/STOCK ISSUANCE PLAN

     This AMENDMENT is made as of March 31, 2002 (this "Amendment") to the
Egenera, Inc. Amended & Restated 2000 Stock Option/Stock Issuance Plan adopted
by the Board of Directors of Egenera, Inc. on April 28, 2000 and amended and
restated on September 6, 2001 (the "Plan").

     Section 1. Amendment to the Plan. The Plan is hereby amended by deleting in
its entirety the existing Section 5 of the Plan and inserting in place thereof
the following:

     5.   Stock. The stock subject to Options, Awards and Purchases shall be
authorized but unissued shares of common stock of the Company ("Common Stock"),
or shares of Common Stock reacquired by the Company in any manner. Subject to
adjustment as provided in Paragraph 14, the aggregate number of shares that may
be issued under the Plan is 18,250,000 shares of Common Stock. In no event shall
the number of shares subject to all Options, Awards or Purchases under the Plan
at the time of the grant of, and including the shares subject to, any Option,
Award or Purchase exceed 18,250,000 shares of Common Stock (as adjusted pursuant
to Paragraph 14) (a) less (i) the number of shares then subject to options
granted pursuant to the Company's 2001 California Stock Option/Stock Issuance
Plan (as the same may be amended and in effect from time to time, the
"California Plan") and (ii) without duplication of any shares described in the
foregoing clause (i), the number of shares previously issued pursuant to the
exercise of any option granted, or award or purchase under the California Plan,
(b) plus the number of shares originally issued pursuant to the exercise of any
option granted, or award or purchase under the California Plan or this Plan that
are repurchased by the Company pursuant to contractual rights held by the
Company and at repurchase prices not exceeding the respective original purchase
prices (or fair market value of such shares as approved by the Board of
Directors) paid by such persons to the Company. If any option granted under the
Plan or under the California Plan shall expire or terminate for any reason
without having been exercised in full or shall cease for any reason to be
exercisable in whole or in part, the unpurchased shares subject to such Option
or option shall again be available for grants of Stock Rights under the Plan.

     Section 2. Effectiveness. This Amendment shall be effective as of the date
hereof upon the adoption of this Amendment by the Board.

     Section 3. Ratification. Except as otherwise expressly set forth herein,
all terms and conditions of the Plan are hereby ratified and confirmed and shall
remain in full force and effect.

      Adopted by the Board of Directors and Stockholders on March 31, 2002

                                                                              11
<PAGE>

                                 AMENDMENT NO. 2
                                       TO
                              AMENDED AND RESTATED
                      2000 STOCK OPTION/STOCK ISSUANCE PLAN

     This AMENDMENT is made as of May 15, 2002 (this "Amendment") to the
Egenera, Inc. Amended & Restated 2000 Stock Option/Stock Issuance Plan adopted
by the Board of Directors of Egenera, Inc. on April 28, 2000, amended and
restated on September 6, 2001, and amended on March 31, 2002 (the "Plan").

     Section 1. Amendment to the Plan. The Plan is hereby amended by deleting in
its entirety the existing Section 5 of the Plan and inserting in place thereof
the following:

     5.   Stock. The stock subject to Options, Awards and Purchases shall be
authorized but unissued shares of common stock of the Company ("Common Stock"),
or shares of Common Stock reacquired by the Company in any manner. Subject to
adjustment as provided in Paragraph 14, the aggregate number of shares that may
be issued under the Plan is 25,250,000 shares of Common Stock. In no event shall
the number of shares subject to all Options, Awards or Purchases under the Plan
at the time of the grant of, and including the shares subject to, any Option,
Award or Purchase exceed 25,250,000 shares of Common Stock (as adjusted pursuant
to Paragraph 14) (a) less (i) the number of shares then subject to options
granted pursuant to the Company's 2001 California Stock Option/Stock Issuance
Plan (as the same may be amended and in effect from time to time, the
"California Plan") and (ii) without duplication of any shares described in the
foregoing clause (i), the number of shares previously issued pursuant to the
exercise of any option granted, or award or purchase under the California Plan,
(b) plus the number of shares originally issued pursuant to the exercise of any
option granted, or award or purchase under the California Plan or this Plan that
are repurchased by the Company pursuant to contractual rights held by the
Company and at repurchase prices not exceeding the respective original purchase
prices (or fair market value of such shares as approved by the Board of
Directors) paid by such persons to the Company. If any option granted under the
Plan or under the California Plan shall expire or terminate for any reason
without having been exercised in full or shall cease for any reason to be
exercisable in whole or in part, the unpurchased shares subject to such Option
or option shall again be available for grants of Stock Rights under the Plan.

     Section 2. Effectiveness. This Amendment shall be effective as of the date
hereof upon the adoption of this Amendment by the Board.

     Section 3. Ratification. Except as otherwise expressly set forth herein,
all terms and conditions of the Plan are hereby ratified and confirmed and shall
remain in full force and effect.

       Adopted by the Board of Directors and Stockholders on May 15, 2002

                                                                              12
<PAGE>

Amendment No. 3 to Amended and Restated 2000 Stock Option/Stock Issuance Plan

     This AMENDMENT is made as of December 19, 2003 (this "Amendment") to the
Egenera, Inc. Amended & Restated 2000 Stock Option/Stock Issuance Plan adopted
by the Board of Directors of Egenera, Inc. on April 28, 2000, amended and
restated on September 6, 2001, and amended on each of March 31, 2002 and May 15,
2002 (the "Plan").

     Section 1. Amendment to the Plan. The Plan is hereby amended by deleting in
its entirety the existing Section 5 of the Plan and inserting in place thereof
the following:

     5.   Stock. The stock subject to Options, Awards and Purchases shall be
authorized but unissued shares of common stock of the Company ("Common Stock"),
or shares of Common Stock reacquired by the Company in any manner. Subject to
adjustment as provided in Paragraph 14, the aggregate number of shares that may
be issued under the Plan is 28,750,000 shares of Common Stock. In no event shall
the number of shares subject to all Options, Awards or Purchases under the Plan
at the time of the grant of, and including the shares subject to, any Option,
Award or Purchase exceed 28,750,000 shares of Common Stock (as adjusted pursuant
to Paragraph 14) (a) less (i) the number of shares then subject to options
granted pursuant to the Company's 2001 California Stock Option/Stock Issuance
Plan (as the same may be amended and in effect from time to time, the
"California Plan") and (ii) without duplication of any shares described in the
foregoing clause (i), the number of shares previously issued pursuant to the
exercise of any option granted, or award or purchase under the California Plan,
(b) plus the number of shares originally issued pursuant to the exercise of any
option granted, or award or purchase under the California Plan or this Plan that
are repurchased by the Company pursuant to contractual rights held by the
Company and at repurchase prices not exceeding the respective original purchase
prices (or fair market value of such shares as approved by the Board of
Directors) paid by such persons to the Company. If any option granted under the
Plan or under the California Plan shall expire or terminate for any reason
without having been exercised in full or shall cease for any reason to be
exercisable in whole or in part, the unpurchased shares subject to such Option
or option shall again be available for grants of Stock Rights under the Plan.

     Section 2. Effectiveness. This Amendment shall be effective as of the date
hereof upon the adoption of this Amendment by the Board.

     Section 3. Ratification. Except as otherwise expressly set forth herein,
all terms and conditions of the Plan are hereby ratified and confirmed and shall
remain in full force and effect.

    Adopted by the Board of Directors and Stockholders on December 19, 2003

                                                                              13
<PAGE>

                               AMENDMENT NO. 4 TO
           AMENDED AND RESTATED 2000 STOCK OPTION/STOCK ISSUANCE PLAN
                                     AND TO
                2001 CALIFORNIA STOCK OPTION/STOCK ISSUANCE PLAN

     This Amendment is made effective as of April 7, 2004 (this "Amendment") to
each of (a) the Egenera, Inc. Amended & Restated 2000 Stock Option/Stock
Issuance Plan adopted by the Board of Directors of Egenera, Inc. on April 28,
2000, as amended and restated on September 6, 2001 and amended on each of March
31, 2002, May 15, 2002 and December 19, 2003 (the "General Plan"), and (b) the
Egenera, Inc. 2001 California Stock Option/Stock Issuance Plan adopted by the
Board of Directors of Egenera, Inc. on September 6, 2001, as amended on each of
March 31, 2002, May 15, 2002 and December 19, 2003 (the "California Plan" and
together with the General Plan, the "Plans").

     Section 1. Section 9B of each of the Plans is hereby amended by deleting in
its entirety the existing Section 9B in each of the Plans and inserting in place
thereof the following new Section 9B:

          "B.  Options granted under the Plan may provide for payment of the
     exercise price to the extent (if at all) provided in the option agreement:
     (i) by delivery to the Company of cash or wire transfer or a check payable
     to the order of the Company in an amount equal to the purchase price per
     share as hereinabove set forth times the number of shares so purchased (the
     "exercise price"); (ii) by delivery of a recourse promissory note of the
     optionee bearing interest payable not less often than annually at such
     market rate for the optionee at the date of exercise as will avoid adverse
     accounting consequences (including without limitation variable security
     accounting treatment under generally accepted accounting principles) and
     otherwise payable on such terms as are specified by the Board in its sole
     discretion, together with cash, a wire transfer or a check payable to the
     Company in an amount equal to the par value of the shares to be issued upon
     exercise of this option; (iii) by delivery to the Company of shares of
     Common Stock of the Company already both owned and vested by the optionee
     for at least six (6) months having a fair market value, as of the date of
     exercise, determined by the Board to be equal in amount to the exercise
     price of the option being exercised; (iv) if a public market for shares of
     Common Stock of the Company at the time exists, the optionee may make
     payment by delivery of an irrevocable direction to a securities broker to
     sell the shares and to deliver all or part of the sale proceeds to the
     Company in payment of the aggregate exercise price therefor; (v) pursuant
     to a program developed under Regulation T as promulgated by the Federal
     Reserve Board; or (vi) by any combination of the above methods of payment."

                                                                              14
<PAGE>

     Section 2. Section 23 of each of the Plans is hereby amended by deleting in
its entirety the existing Section 23 in each of the Plans and inserting in place
thereof the following new Section 23:

          "23. Withholding. The Company shall have the right to deduct from
     payments of any kind otherwise due to the optionee the statutory minimum
     amount of federal, state or local taxes of any kind required by law to be
     withheld with respect to any shares issued upon exercise of Options under
     the Plan or upon the grant of an Award, the making of a Purchase of Common
     Stock for less than its fair market value, the making of a Disqualifying
     Disposition (as defined in Paragraph 24), or the vesting of restricted
     Common Stock acquired pursuant to a Stock Right. The Board in its sole
     discretion may condition the exercise of an Option, the grant of an Award,
     the making of a Purchase, or the vesting of restricted shares acquired by
     exercising a Stock Right on the grantee's payment of such withholding
     taxes. Subject to the prior approval of the Company, which may be withheld
     by the Company in its sole discretion, the grantee may elect to satisfy
     such obligations, in whole or in part, by delivering to the Company shares
     of Common Stock already both owned and vested by the grantee for at least
     six (6) months. The shares so delivered or withheld shall have a fair
     market value equal to such withholding obligation, and shall not be subject
     to any repurchase, forfeiture, unfulfilled vesting or other similar
     requirements. The fair market value of the shares used to satisfy such
     withholding obligation shall be determined by the Company as of the date of
     delivery of such shares to the Company. Notwithstanding the foregoing, in
     the case of a Reporting Person, no election to use shares for the payment
     of withholding taxes shall be effective unless made in compliance with any
     applicable requirements of Rule 16b-3 (unless it is intended that the
     transaction not qualify for exemption under Rule 16b-3)."

     Section 3. Effectiveness. This Amendment shall be effective as of the date
hereof upon the adoption of this Amendment by the Board.

     Section 4. Ratification. Except as otherwise expressly set forth herein,
all terms and conditions of the Plans are hereby ratified and confirmed and
shall remain in full force and effect.

     Adopted by the Board of Directors and Stockholders by Written Consent
                         effective as of April 7, 2004

                                                                              15

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