Document:

EX-10.46

 EXHIBIT 10.46 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
 ASSET PURCHASE AGREEMENT 

among: 
 EIGER BIOPHARMACEUTICALS,
INC., 
 a Delaware corporation; 

and 
 TRACEY MCLAUGHLIN AND
COLLEEN CRAIG 
  
  

Dated as of September 25, 2015 
  

 

 ASSET PURCHASE AGREEMENT 

THIS ASSET PURCHASE AGREEMENT is entered into, effective as of September 25, 2015 (the “Effective
Date”), by and between EIGER BIOPHARMACEUTICALS, INC., a Delaware corporation (“Purchaser”) and TRACEY MCLAUGHLIN AND COLLEEN CRAIG (each individually, “Seller”, collectively,
“Sellers”). Purchaser and Sellers are referred to herein collectively as the “Parties” and individually as a “Party.” Certain other capitalized terms used in this Agreement are
defined in Exhibit A. 
 RECITALS 

A. Purchaser and Sellers wish to provide for the sale by Sellers to Purchaser of the Designated Assets (as defined in Section 1.1)
by Purchaser on the terms and subject to the conditions set forth in this Agreement. 
 B. In connection with the sale of the
Designated Assets, Purchaser is entering into a Consulting Agreement with each Seller in substantially the form attached hereto as Exhibit B (the “Consulting Agreement”). 

C. This Agreement has received the requisite approvals by Purchaser and Sellers. 

AGREEMENT 
 The Parties,
intending to be legally bound, agree as follows: 
 SECTION 1. SALE OF DESIGNATED ASSETS; RELATED TRANSACTIONS. 

1.1 Sale of Designated Assets. Each Seller hereby sells, assigns, transfers, conveys and delivers to Purchaser the entirety of their
right, title and interest (if any) in and to the Designated Assets on the terms and subject to the conditions set forth in this Agreement. The “Designated Assets” shall mean the following assets (to the extent
not previously or otherwise required to be assigned by Sellers to the Leland Stanford Junior University (“Stanford”) under their existing employment agreements): 

(a) All rights and interests in and to Patents, copyrights, trademarks, trade secrets, know-how, and
documentation and related applications related to extending, including provisional patent application Docket No.: [ * ] filed by Sellers [ * ] (the “HH Patents”), if and to the extent any of the foregoing is the intellectual
property of Sellers and not subject to a contractual obligation on the part of Sellers to assign the same to Stanford or not otherwise assigned and subject to the License Agreement (as defined below); 

(b) All techniques, technology, trade secrets, inventions (whether patentable or not), methods, know-how, data and results (including
pharmacological, toxicological and clinical data and results), analytical and quality control data and results, regulatory documents including investigational new drug applications (INDs) (other than the current IND designated as [ * ] involving [ *
]), and correspondence, as well as other information related to exendin and its 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
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uses in the possession of Sellers, if and to the extent any of the foregoing is the intellectual property of Sellers and not subject to a contractual obligation on the part of Sellers to assign
the same to Stanford; and 
 (c) The License Agreement between Stanford and Sellers dated May 4, 2015
(the “License Agreement”), pursuant to which Stanford granted to Sellers an exclusive, worldwide license to use, make, have made, market and sell products in all fields of use based upon, used or made in accordance with that
certain invention described in Stanford Docket §12- 372, including as further described in the HH Patents, involving the use of exendin (the “Invention”). The License Agreement provides for making a product based on the
Invention and any modifications, improvements or variations thereof (the “Product”) “available for public use and benefit” and Purchaser acknowledges those obligations thereunder. 

1.2 Purchase Price. The purchase price for the Designated Assets shall be (the “Purchase Price”): 

(a) Within [ * ] of the Effective Date, the Purchaser shall issue to each of the Sellers: (i) shares of
Common Stock of the Company pursuant to a customary Company common stock purchase agreement representing [ * ] of the total number of the Company’s issued and outstanding shares of capital stock (excluding all shares reserved but unissued under
the Plan and any issuances to the Sellers pursuant to this Section 1.2) as of immediately prior to the date of issuance of the shares of Common Stock, which shall not be subject to any vesting; (ii) non-qualified options to purchase
Common Stock of the Company to each Seller under Purchaser’s 2009 Equity Incentive Plan (the “Plan”) equal to [ * ] of the total number of the Company’s issued and outstanding shares of capital stock (excluding all
shares reserved but unissued under the Plan and any issuances to the Sellers pursuant to this Section 1.2) as of immediately prior to the date of issuance of such options, which options shall have an exercise price equal to the fair
market value on the date of grant, as reasonably determined by the Purchaser’s Board of Directors and shall vest in increments of [ * ] per month from the date of grant for each month after the Effective Date, provided that such Seller is
providing Continuous Service (as defined under the Plan) to the Company, it being understood that being on unpaid retainer shall satisfy such definition (collectively, the issuances under subclauses l.2(a)(i) and (ii), the “Initial
Time-Based Equity”) ; and (iii) non-qualified options to each Seller to purchase Common Stock of the Company to each Seller under the Plan to purchase [ * ] of the total number of the Company’s issued and outstanding shares of
capital stock (excluding all shares reserved but unissued under the Plan and any issuances to the Sellers pursuant to this Section 1.2) (the “Milestone Options”), which Milestone Options shall have a term of [ * ]
and shall vest upon the earlier of: (A) [ * ] and (B) [ * ] (each, a “Milestone Vesting Trigger”), provided that for clarity, with respect to the option grants pursuant to this subclause (iii), vesting shall occur
on the achievement of the Milestone Vesting Trigger by the Company regardless of whether Sellers are providing Continuous Service (as defined under the Plan) at the applicable time of achievement during the term of such Milestone Options. The
occurrence of a Milestone Vesting Trigger shall be determined by Purchaser’s Board of Directors in its reasonable discretion, which decision shall be binding upon the Parties and final; 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
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 (b) At the closing of the first round of financing after the
date of this Agreement pursuant to which Purchaser sells shares of its equity resulting in gross proceeds to the Company of at least [ * ], including a reverse merger whose primary purpose is financing (the “Financing”),
Purchaser will issue to each Seller additional non-qualified options to purchase Common Stock of the Company (the “Total Options”) to each Seller under the Plan (the “Top-Up Options”) under the Plan
pursuant to this Section l.2(b) in an amount sufficient to ensure that the sum of the Initial Time-Based Equity plus the Milestone Options plus the Top-Up Options held by each Seller represents [ * ] of the total number of the
Company’s issued and outstanding shares of capital stock (excluding all shares reserved but unissued under the Plan and any issuances to the Sellers pursuant to this Section 1.2) as of immediately following the initial closing of
the Financing. The Top-Up Options shall have an exercise price equal to the fair market value on the date of grant, as reasonably determined by the Purchaser’s Board of Directors (or if the Company is publicly traded, pursuant to the terms of
the Plan), and shall vest as follows: (i) [ * ] of the shares under the Top-Up Options (i.e., [ * ] of the of the total number of the Company’s issued and outstanding shares of capital stock (excluding all shares reserved but unissued
under the Plan and any issuances to the Sellers pursuant to this Section 1.2) as of immediately prior to the date of issuance of options) shall be vested on issuance and the remainder as of immediately prior to the date of issuance of
options) shall vest in increments of [ * ] per month from the Effective Date, provided that such Seller is providing Continuous Service (as defined under the Plan) to the Company, it being understood that being on unpaid retainer shall satisfy such
definition; and (ii) the other [ * ] of the Top-Up Options (i.e., [ * ] of the of the total number of the Company’s issued and outstanding shares of capital stock (excluding all shares reserved but unissued under the Plan and any issuances
to the Sellers pursuant to this Section 1.2), shall vest upon the occurrence of a Milestone Vesting Trigger, provided that for clarity, with respect to the Top-Up Option grants pursuant to this subclause (ii), vesting shall occur on the
achievement of the Milestone Vesting Trigger by the Company regardless of whether Sellers are providing Continuous Service (as defined under the Plan) at the applicable time of achievement during the term of such Top-Up Options. The occurrence of a
Milestone Vesting Trigger shall be determined by Purchaser’s Board of Directors in its reasonable discretion, which decision shall be binding upon the Parties and final; 

(c) [ * ] shall be payable to each Seller, within [ * ] following [ * ], as reasonably determined by Purchaser’s Board of
Directors; 
 (d) [ * ] shall be payable to each Seller, within [ * ] following [ * ], as reasonably determined by Purchaser’s
Board of Directors; 
 (e) [ * ] payable to each Seller, within [ * ] following [ * ], as reasonably determined by Purchaser’s
Board of Directors; and 
 (f) The Royalty Payments, payable if and to the extent provided in Section 1.4 below. 

For clarity, the Parties contemplate that the Sellers shall each hold Initial Options and Top-Up Options totaling [ * ] of the outstanding
shares of equity of the Company following the Financing. For further clarity, the payments in Sections l.2(c), (d) and (e) of the Purchaser Price 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
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shall be payable only once to each Seller upon the first successful achievement by the Purchaser of such payment event with respect to the Product, as determined by Purchaser’s Board of
Directors, as aforesaid. 
 1.3 Assumed Liabilities. Purchaser shall not assume any Liabilities of Sellers (whether or not related to
the Designated Assets), except for the continuing obligations under the terms of the License Agreement arising following the Closing Date, but solely to the extent not related to or arising from any fact, circumstance, act, breach or violation
occurring prior to the Closing Date. 
 1.4 Contingent Consideration. 

(a) Commencing with the date the Product is first commercially sold and until the last to expire of any
Valid Claim of any of the Patents licensed under the License Agreement, as applicable (the “Royalty Period”), each Seller shall be entitled to receive within [ * ] after the end of each calendar year during the Royalty Period
a payment equal to [ * ] of the Annual Net Sales of such Product made during such calendar year (such payments collectively, the “Royalty Payments”). The determination as to the calculation of the Royalty Payments shall be
reasonably made by Purchaser’s Board of Directors, in its reasonable discretion. 
 (b)
Concurrently with each Royalty Payment made hereunder, Purchaser shall submit to Sellers a written statement of account, which statement shall show (i) the Annual Net Sales in a manner consistent with the definition thereof,
and (ii) the manner in which the Royalty Payment was calculated (the “Royalty Statement”). 

(c) For [ * ] following the submission of a Royalty Statement, Sellers and their agents and representatives shall have the right upon
written request to conduct reasonable inspection and audit of Purchaser’s relevant books and records for the sole purpose of verifying the accuracy of the Royalty Statements, provided that: (i) such written request must be reasonable;
(ii) Purchaser shall receive reasonable advance notice of such request; (iii) such inspection or audit shall take place during Purchaser’s regular business hours and at the place where such books and records are maintained;
(iv) Purchaser may demand that the Sellers, their agents and representative will execute a nondisclosure agreement in a form reasonably satisfactory to Purchaser prior to such inspection or audit; and (v) in no event shall Purchaser be
required to provide access to information that is subject to attorney-client privilege. Any such inspection or audit by Sellers shall be at their sole expense. 

1.5 Transfer Taxes. Sellers shall be liable for any sales Taxes, use Taxes, transfer Taxes or similar Taxes, charges or fees that may
become payable in connection with the sale of the Designated Assets to Purchaser. Purchaser and Sellers shall cooperate to reduce the amount of such Taxes to the extent permitted by applicable law. 

1.6 Allocation. The consideration referred to in Section 1.2 shall be allocated among the Designated Assets pursuant to a
purchase price allocation prepared by Purchaser, which shall be delivered to Sellers within [ * ] of the Effective Date, and no Party shall file any tax return or 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
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other document with, or make any statement or declaration to, any governmental body that is inconsistent with such allocation, except as required by applicable law. 

1.7 Closing. 

(a) The closing of the sale of the Designated Asset to Purchaser pursuant to this Agreement (the
“Closing”) shall take place concurrently with the execution and delivery of this Agreement (the “Closing Date”). 

(b) At the Closing: 

(i) Purchaser and each Seller shall execute and deliver to each other a Consulting Agreement; and 

(ii) Purchaser and each Seller shall execute and deliver to the other Party that certain instrument, titled
“Amendment No. 1 To License Agreement” in the form attached hereto as Exhibit C, thereby effectuating the assignment of the License Agreement to Purchaser. (With reference to said Amendment No. 1 to License
Agreement, in the interest of clarity, the Parties agree that obligations set forth in Section 13.3 of the amended License Agreement do not and shall not apply to Sellers hereunder.) 

SECTION 2. REPRESENTATIONS AND WARRANTIES OF SELLER. 

Sellers, severally and not jointly, each represent and warrant to Purchaser that, except as set forth in the Disclosure Schedule
(it is hereby agreed that any information disclosed in any section or subsection of the Disclosure Schedule shall be deemed to relate to and qualify the corresponding numbered or lettered section or subsection of this Agreement and any other
representation or warranty of Sellers where such disclosure would reasonably be deemed to apply) as of the Effective Date (for the avoidance of doubt and sake of clarity, in this Section 2, each Seller shall only make each representation
with respect to itself, notwithstanding the fact that “Sellers” or “each Seller” may be referenced): 

2.1 License Agreement. Sellers have delivered to Purchaser accurate and complete copies of the License Agreement. The License Agreement
is valid and in full force and effect. Neither Seller nor any of the other parties to the License Agreement has violated or breached, or declared or committed any default under the License Agreement. No event has occurred, and no circumstance or
condition exists, that might (with or without notice or lapse of time) result in a violation, breach or default by any Seller or any of the other parties to the License Agreement. Neither Seller has waiver any rights under the License Agreement.
There are no material disputes regarding the License Agreement and, to the knowledge of Sellers, the relationship between Sellers and Stanford is good. 

2.2 Authority; Binding Nature of Agreements. Each Seller has full power and authority to enter into, perform and comply with its
obligations under this Agreement, and any other Transaction Agreement which such Seller is required to enter into hereunder and this Agreement constitutes and any such other Transaction Agreement when executed will constitute  

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
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valid, legally binding and enforceable obligations on such Seller in accordance with its or their respective terms, subject to: (i) laws of general application relating to bankruptcy,
insolvency and the relief of debtors; and (ii) rules of law governing specific performance, injunctive relief and other equitable remedies. 

2.3 Non-Contravention. The execution and delivery by Sellers of the Transactional Agreements, and the consummation of the transactions
contemplated by the Transaction Agreements, including the sale of the Designated Assets by Sellers to Purchaser will not result in the imposition or creation of any lien or Encumbrance upon or with respect to any of the Designated Assets. Sellers
are not required to obtain any additional consent from any Person in connection with the execution and delivery of the Transactional Agreements or the consummation of the transactions contemplated thereby, including the sale of the Designated Assets
to Purchaser. 
 2.4 Compliance with Law; Permits. As it relates to the Designated Assets: (a) each Seller has at all
times been and is now in compliance with each Legal Requirement that is applicable to the ownership or use of the Designated Assets; (b) no event has occurred, and no condition or circumstance exists, that might (with or without notice or lapse
of time) constitute or result in a violation by any Seller of, or a failure on the part of any Seller to comply with, any Legal Requirement; and (c) no Seller has received, at any time, any notice or other communication (in writing or
otherwise) from any governmental body or any other Person regarding any actual or alleged violation of, or failure to comply with, any Legal Requirement. 

2.5 Title to Transferred Assets. Sellers own, and have good and valid title to, all of the Designated Assets, free and clear of any
Encumbrances, subject to the qualifications pertaining thereto with respect to Stanford as set forth in Section 1.1, subparts (b) and (c). 

2.6 Tax Matters. Each Tax with respect to the Designated Assets required to have been paid, or claimed by any governmental body to be
payable, by Sellers has been duly paid in full on a timely basis. With respect to the Designated Assets, no claim or other Proceeding is pending or, to the knowledge of Sellers, has been threatened in respect of any Tax. 

2.7 Restriction on Business Activities. There is no order to which Sellers are a party to or otherwise binding upon Sellers or any of
their properties or assets (including the Designated Assets) which has or may reasonably be expected to have the effect of prohibiting or impairing the use of the Designated Assets or limiting the freedom of Purchaser to engage in any line of
business or to compete with any Person. Sellers have not entered into any contract under which they are, or Purchaser will be after the Closing, restricted from using the Designated Assets to create products or services and sales, licensing,
marketing, manufacturing or otherwise distributing or using any such products, services or any of the Designated Assets or from providing services to customers or potential customers or any class of customers, m any geographic area, during any
period of time, or in any segment of the market. 
 2.8 No Liability. The Sellers have no Liability with respect to the
Designated Assets. 
  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
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 2.9 Intellectual Property. The Sellers exclusively own or otherwise a valid right to use
and practice (through the License Agreement) the Invention, under the HH Patent and the other intellectual property included in the Designated Assets (the “Designated IP”), free of any Encumbrances, including
obligations to pay royalties or indemnification obligations (except as otherwise provided in the License Agreement). The Designated IP is valid, subsisting and enforceable. There are no outstanding options, licenses, or agreements of any kind
relating to the Designated IP. To Sellers’ knowledge, the Designated IP does not violate or infringe any intellectual property right of any other Person. Neither Seller has received any communication alleging that any Seller or that the
Designated IP has violated or would violate any of the patents, trademarks, service marks, tradenames, copyrights, trade secrets or other proprietary rights or processes of any other Person. Neither the execution or delivery of this Agreement and
the other Transaction Agreements, nor the use of the Designated Assets as currently proposed to be conducted will conflict with or result in a breach of the terms, conditions, or provisions of, or constitute a default under, any contract, covenant
or instrument under which any Seller is obligated. 
 2.10 Proceedings. There is no pending or threatened Proceeding:
(a) that involves or otherwise can affect any Seller or any of the Designated Assets; or (b) that challenges, or that may have the effect of preventing, delaying, making illegal or otherwise interfering with, the transactions contemplated
by this Agreement or the other Transaction Agreements. No event has occurred, and no claim, dispute or other condition or circumstance exists, that will or could be expected to, give rise to or serve as a basis for the commencement of any such
Proceeding. There is no order, writ, injunction, judgment or decree to which any Seller, or any Designated Asset, is subject. 

2.11 No Brokers. Sellers are not obligated to pay any brokerage, commission, finder’s fee or similar fee in connection with the
transactions contemplated hereby. 
 2.12 Full Disclosure. Sellers have disclosed to Purchaser all facts known to them that are
material to the Designated Assets, or may have material effect on Purchaser’s consideration of the execution of this Agreement or any other Transaction Agreement, or consummation of the transactions contemplated hereby or thereby. No
representation or warranty by Sellers in this Agreement or any Schedule hereto contains any untrue statement of a material fact or omits to state any material fact necessary, in each case with respect to the Designated Assets, in order to make the
statement made herein or therein, in light of the circumstances under which they were made, not misleading. 
 SECTION 3. REPRESENTATIONS AND
WARRANTIES OF PURCHASER. 
 Purchaser represents and warrants to Sellers that: 

3.1 Due Organization. Purchaser is a limited liability company duly organized, validly existing and in good standing under the laws of
Delaware. 
 3.2 Authority; Binding Nature of Agreements. Purchaser has the requisite corporate power and authority to enter
into and to deliver each of the Transactional Agreements  
  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
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to which it is a party and to perform its obligations under each such Transactional Agreement, and the execution, delivery and performance by Purchaser of each of the Transactional Agreements to
which it is a party have been duly authorized by all necessary corporate action on the part of Purchaser. Each of the Transactional Agreements constitutes a legal, valid and binding obligation of Purchaser, enforceable against it or them in
accordance with its terms, except to the extent that enforcement thereof may be limited by: (a) bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance or other similar laws now or hereafter in effect relating to
creditors’ rights generally; and (b) general principles of equity (regardless of whether enforceability is considered in a Proceeding at law or in equity). 

3.3 Non-Contravention. The execution and delivery by Purchaser of the Transactional Agreements, and the purchase of the Designated
Assets by Purchaser from Sellers will not result in a violation of the charter documents of Purchaser. 
 3.4 Capitalization
Table. Exhibit D sets forth the true and correct capitalization of the Company as of the Effective Date. 
 SECTION 4. SURVIVAL AND
INDEMNIFICATION. 
 4.1 Survival of Representations. 

(a) The representations and warranties of Sellers shall survive the Closing and the sale of the Designated
Assets to Purchaser and shall expire on the date that is [ * ] following the Closing Date (the “Representation Termination Date”); provided, however, that if Purchaser provides Seller a
written notice relating to any representation or warranty prior to the applicable Representation Termination Date, then the claim(s) asserted in such Claim Notice shall survive the Representation Termination Date until such time as such claim is (or
claims are) fully and finally resolved. The limitations set forth in this Section 4.l(a) shall not apply in the case of intentional misrepresentation, willful misconduct or fraud (“Fraud”). The covenants and
obligations of each Party shall survive the Closing and the sale of the Designated Assets to Purchaser and shall expire upon the applicable statute of limitations, which statute shall start to run on the Closing Date, except in the case of
Fraud. 
 (b) For purposes of this Agreement, a “Claim Notice”
relating to a particular representation or warranty shall be deemed to have been given if Purchaser delivers to Sellers a written notice stating that Purchaser believes that there is or has been a breach of a representation or warranty, asserting a
claim for recovery under Section 4.2 based on such alleged breach and setting forth in reasonable detail: (i) the basis for, and a brief description of the circumstances supporting, Purchaser’s belief that there is or has been
such a breach; and (ii) to the extent practicable, a non-binding, preliminary estimate of the aggregate dollar amount of the actual and potential Damages that have arisen and may arise as a result of such breach. 

4.2 Indemnification. From and after the Closing Date (but subject to the limitations set forth in this Section 4), each of
the Sellers shall individually, and not jointly, hold harmless, reimburse and indemnify Purchaser and its agents and representatives from and against, any  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
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Damages that are suffered or incurred by Purchaser and that arise from or as a result of or relating to: 

(a) Any inaccuracy in or breach of any of the representations or warranties made by the applicable Seller in this Agreement or in any
other Transaction Agreement; 
 (b) Any breach of any covenant or obligation of the applicable Seller contained in this
Agreement or any other Transaction Agreement; and 
 (c) Any Liability of such Seller, except for the Assumed Liabilities.

 4.3 Cap. Notwithstanding anything to the contrary, each Seller’s liability to Purchaser hereunder shall be capped at the
value of such Seller’s vested shares comprising the Purchase Price (with the value of such shares or options, to the extent necessary in determining the cap, as reasonably determined by Purchaser’s Board of Directors based upon the
available information pertaining thereto) for each of the Sellers pursuant to this Agreement; provided that, to the extent that the liability to Purchaser exceeds the value of the vested shares comprising the Purchase Price with respect to any claim
of Purchaser, the liability shall be satisfied in part by any vested shares or options and shall remain in effect until there are no longer shares or options subject to vesting. It is further agreed that each Seller shall have the right to satisfy
any liability to Purchaser hereunder by returning to Purchaser that portion of its vested shares or options whose value equals the amount of said liability, not to exceed the return of all of its shares or options comprising the Purchase Price (with
the value of such shares or options, to the extent necessary in determining the cap, as reasonably determined by Purchaser’s Board of Directors based upon the available information pertaining thereto). The limitation set forth in this
Section 4.3 shall not apply in the case of Fraud and shall survive the termination or expiration of this Agreement. 
 4.4
Defense of Third-Party Claims. In the event of the assertion or commencement by any Person of any claim or Proceeding (whether against Purchaser or against any other Person) with respect to which Purchaser may be entitled to indemnification,
compensation or reimbursement pursuant to this Section 4.4, Purchaser shall have the right, at its election, to proceed with the defense of such claim or Proceeding on its own with counsel reasonably satisfactory to Sellers (which
consent may not be unreasonably withheld, delayed or conditioned). Purchaser shall have the right to settle, adjust or compromise such claim or Proceeding; provided, however, that if Purchaser settles, adjusts or compromises any
such claim or Proceeding without the consent of Sellers (such consent not to be unreasonably withheld or delayed), such settlement, adjustment or compromise shall not be conclusive evidence of the amount of Damages incurred by Purchaser in
connection with such claim or Proceeding. Purchaser shall give Sellers prompt notice after it becomes aware of the commencement of any such claim or Proceeding against Purchaser; provided, however, that any failure on the part
of Purchaser to so notify Sellers shall not limit any of the obligations of Sellers, or any of the rights of Purchaser, under this Section 4.4 (except to the extent such failure materially prejudices the defense of such Proceeding). If
Purchaser does not elect to proceed with the defense of any such Proceeding, Sellers may proceed with the defense of such Proceeding with counsel reasonably  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
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satisfactory to Purchaser; provided, however, that Sellers may not settle or compromise any such Proceeding without the prior written consent of Purchaser. 

SECTION 5. CERTAIN POST-CLOSING COVENANTS. 

5.1 Further Assurances. From and after the Closing, each of Purchaser and Sellers will, to the extent reasonably requested by the other
Party and at such other Party’s sole expense, execute and deliver such documents and instruments and take such other actions as such other Party may reasonably request in order to consummate and make effective the transactions contemplated by
this Agreement. On and after the Closing Date, each Seller shall execute such documents, further instruments of sale, transfer, conveyance, assignment and confirmation and other papers and take such further actions as may be reasonably required to
transfer, convey and assign to Purchaser, and to confirm Purchaser’s title to, all of the Designated Assets. 
 5.2
Publicity. Sellers agree that, on and at all times after the date of this Agreement: (a) no press release or other publicity concerning any of the transactions contemplated hereby shall be issued or otherwise disseminated by it or on its
behalf without Purchaser’s prior written consent; and (b) Sellers shall continue to keep the terms of this Agreement strictly confidential. 

5.3 Tax Cooperation. Purchaser and Sellers agree to furnish or cause to be furnished to each other, upon request, as promptly as
practicable, such information and assistance relating to the Designated Asset (including access to books and records) as is reasonably necessary for the filing of all tax returns, and making of any election related to taxes, the preparation for any
audit by any taxing authority and the prosecution or defense of any claim, suit or Proceeding relating to any tax return. 
 5.4
Non-Competition. 
 (a) Non-Competition. Each Seller hereby covenants, acknowledges and agrees that it will not, at any
time during [ * ] from the Closing Date, either directly or indirectly, as principal, agent, owner, partner, employee, consultant, shareholder, director or officer, as the case may be, in any manner whatsoever, own, be engaged in, be concerned with,
be interested in, operate, have any financial interest in or advance, lend money to, guarantee the debts or obligations of, permit its name or any part thereof to be used or applied by any Person, firm or corporation engaged in or concerned with or
interested in, directly or indirectly, in any Competitive Activity in any territory in which the Products are currently planned to be commercialized, except as a passive shareholder holding less than [ * ] percent of the outstanding shares of a
corporation offering its shares to the public and whose shares are listed and posted for trading on a recognized stock exchange. Notwithstanding the foregoing covenant, Purchaser agrees that said covenant shall not be construed to preclude Sellers
from continuing, during said [ * ] period following the Closing Date, their research and mechanistic studies relating to hyperinsulinemic hypoglycemia in connection with their employment at Stanford. 

(b) Relief. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 11 of 38 

 (i) Injunctive Relief. Sellers acknowledges that breach of Seller’s covenants
contained in this Section 5.4 may cause irreparable harm to the Business, which may not be compensable through monetary damages. Sellers therefore hereby acknowledges that in the event of a breach or a threatened breach by the them or
their respective affiliates of such covenants, Purchaser will be entitled, in addition to any other rights, remedies or damages which may be available to Purchaser, at law or in equity, to obtain an interim and permanent injunction in order to
prevent or restrain any breach or threatened breach of this Agreement by Sellers or their affiliates, partners, employers, employees, servants, agents, representatives, and other Persons directly or indirectly acting for, or on behalf of, or with,
Sellers. Sellers further agree that Purchaser shall be entitled to injunctive relief without having to prove damages and shall be entitled to all of its costs and expenses incurred in order to obtain relief from any such breach under this
Agreement. 
 (ii) Restrictions Reasonable. Purchaser and Sellers acknowledge and confirm that: 

(1) they have been independently advised by their respective counsel with respect to the provisions of this Section 5.4;

 (2) they have negotiated the provisions of Section 5.4 on an equal footing based on equal bargaining power at the
Closing Date; 
 (3) neither Purchaser or Sellers were required or induced by force, threats, or other means of intimidation or in
any other manner to enter into this Agreement or the Transaction Documents; 
 (4) the provisions of this
Section 5 and the Transaction Documents are reasonable and do not go beyond what is necessary to protect the interests of Purchaser; and 

(5) the Transaction Documents are supported by adequate consideration. 

5.5 Commercially Reasonable Efforts. Purchaser hereby agrees to use Commercially Reasonable Efforts to pursue and complete [ * ].

 SECTION 6. MISCELLANEOUS PROVISIONS. 

6.1 Notices. All notices, requests, demands and other communications under this Agreement shall be in writing and shall be deemed to
have been duly given or made as follows: 
 (a) if sent by registered or certified mail in the United States return receipt
requested, upon receipt; (b) if sent designated for overnight delivery by nationally recognized overnight air courier (such as Federal Express), upon receipt; (c) if sent by facsimile transmission before 5:00 p.m. in California, when
transmitted and receipt is confirmed; (d) if sent by facsimile transmission after 5:00 p.m. in California and receipt is confirmed, on the  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 12 of 38 

 
following business day; and (e) if otherwise actually personally delivered, when delivered, provided that such notices, requests, demands and other communications are delivered to the
address set forth below, or to such other address as either Party shall provide by like notice to the other Party: 
 If to
Sellers: 
 Tracey McLaughlin, MD 

300 Pasteur Drive, Room S025 

Stanford, CA 94305-5103 

Facsimile:
                     

and 

Colleen Craig, MD 

300 Pasteur Drive, Room S025 

Stanford, CA 94305-5103 

Facsimile:
                     

With copies (which shall not constitute notice) to: 

Blakely, Sokoloff, Taylor & Zafman LLP 

12400 Wilshire Boulevard 

Suite 700 

Los Angeles, California 90025 

Attention: Norman Zafman 

Facsimile: (310) 820-5988 

If to Purchaser: 

Eiger BioPharmaceuticals, Inc. 

350 Cambridge Avenue, Suite 350 

Palo Alto, CA 94306 

Attention: David Cory 

Facsimile: (415) 203-0934 

With copies (which shall not constitute notice) to: 

Cooley LLP 

3175 Hanover St. 

Palo Alto, CA 94304 

Attention: Glen Sato 

Facsimile: (650) 849-7400 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 13 of 38 

 6.2 Headings. The bold-faced headings contained in this Agreement are for convenience of
reference only, shall not be deemed to be a part of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. 

6.3 Counterparts and Exchanges by Electronic Transmission or Facsimile. This Agreement may be executed in counterparts, each of which
shall constitute an original and both of which, when taken together, shall constitute one agreement. The exchange of a fully executed Agreement (in counterparts or otherwise) by electronic transmission or facsimile shall be sufficient to bind the
Parties to the terms and conditions of this Agreement. 
 6.4 Governing Law; Venue. 

(a) This Agreement shall be construed in accordance with, and governed in all respects by, the internal laws of the State of California
(without giving effect to principles of conflicts of laws). 
 (b) Any Proceeding relating to this Agreement or the enforcement
of any provision of this Agreement shall be brought or otherwise commenced in any state or federal court located in the State of California. Each Party: 

(i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in the State of
California (and each appellate court located in the State of California) in connection with any such proceeding; 
 (ii)
agrees that each state and federal court located in the State of California shall be deemed to be a convenient forum; and 

(iii) agrees not to assert (by way of motion, as a defense or otherwise), in any such Proceeding commenced in any state or federal
court located in the State of California, any claim that such Party is not subject personally to the jurisdiction of such court, that such Proceeding has been brought in an inconvenient forum, that the venue of such Proceeding is improper or that
this Agreement or the subject matter of this Agreement may not be enforced in or by such court. 
 6.5 WAIVER OF TRIAL BY JURY.
EACH PARTY WAIVES THE RIGHT TO A JURY TRIAL IN CONNECTION WITH ANY LAWSUIT, ACTION OR PROCEEDING SEEKING ENFORCEMENT OF SUCH PARTY’S RIGHTS UNDER THIS AGREEMENT. 

6.6 Successors and Assigns; Parties in Interest. Except as otherwise expressly provided herein, the provisions hereof shall inure to the
benefit of, and be binding upon the parties hereto and their respective successors, assigns, heirs, executors and administrators. Sellers may not assign any of their rights or delegate any of their obligations under this Agreement to any other
Person without the prior written consent of Purchaser. Purchaser may freely assign any or all of its rights hereunder, in whole or in part, to any other Person without obtaining the consent or approval of any other Person. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 14 of 38 

 6.7 Waiver. No failure on the part of either Party to exercise any power, right, privilege
or remedy under this Agreement, and no delay on the part of either Party in exercising any power, right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise
of any such power, right, privilege or remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. 

6.8 Specific Performance. Each Party agrees that: (a) in the event of any breach or threatened breach by the other Party of any
covenant, obligation or other provision set forth in this Agreement, such Party shall be entitled (in addition to any other remedy that may be available to it) to: (i) a decree or order of specific performance or mandamus to enforce the
observance and performance of such covenant, obligation or other provision; and (ii) an injunction restraining such breach or threatened breach; and (b) neither Party shall be required to provide any bond or other security in connection
with any such decree, order or injunction or in connection with any related legal proceeding. 
 6.9 Amendments. This Agreement
may not be amended, modified, altered or supplemented other than by means of a written instrument duly executed and delivered on behalf of Sellers and Purchaser. 

6.10 Severability. In the event that any prov1s10n of this Agreement, or the application of any such provision to either Party or set of
circumstances, shall be determined to be invalid, unlawful, void or unenforceable to any extent, the remainder of this Agreement, and the application of such provision to a Party or circumstances other than those as to which it is determined to be
invalid, unlawful, void or unenforceable, shall not be impaired or otherwise affected and shall continue to be valid and enforceable to the fullest extent permitted by law. 

6.11 Expenses. Each Party shall bear and pay all fees, costs and expenses that have been incurred or that are in the
future incurred by, on behalf of or for the benefit of, such Party in connection with the negotiation, preparation and review of this Agreement and the other Transactional Agreements and the consummation and performance of the transactions
contemplated herein; provided, however, that Purchaser shall reimburse the reasonable fees and expenses of Blakely, Sokoloff, Taylor & Zafinan LLP, as counsel to Sellers, not to exceed [ * ]. 

6.12 Entire Agreement. The Transactional Agreements set forth the entire understanding of the Parties relating to the subject matter
thereof and supersede all prior agreements and understandings between the Parties relating to the subject matter thereof. 
 6.13
Construction. 
 (a) For purposes of this Agreement, whenever the context requires: the singular number shall include the
plural, and vice versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include the masculine and feminine genders. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 15 of 38 

 (b) The Parties agree that any rule of contractual construction to the effect that
ambiguities are to be resolved against the drafting Party shall not be applied in the construction or interpretation of this Agreement. 

(c) As used in this Agreement and Exhibit A, the words “include” and “including,” and variations thereof,
shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 

(d) Except as otherwise indicated, all references in this Agreement to “Sections,” “Exhibits” and
“Schedules” are intended to refer to Sections of this Agreement and Exhibits and Schedules to this Agreement. 

[Remainder of page intentionally left blank] 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 16 of 38 

 The Parties have caused this Agreement to be executed and delivered as of the date above
mentioned. 
  

			
	PURCHASER:
	
	EIGER BIOPHARMACEUTICALS, INC.
		
	By:	 	 /s/ David Cory

	Name:	 	David Cory
	Title:	 	President and CEO

  

			
	SELLERS:	 	
	
	 /s/ Tracey McLaughlin

	Tracey McLaughlin
	
	 /s/ Colleen Craig

	Colleen Craig

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 17 of 38 

 LIST OF EXHIBITS 

Exhibit A - Certain Definitions 
 Exhibit B - Form of Consulting
Agreement 
 Exhibit C - Amendment No. 1 To License Agreement Exhibit D - Capitalization Table of the Company 

LIST OF SCHEDULES 
 Disclosure Schedule 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 18 of 38 

 EXHIBIT A 

CERTAIN DEFINITIONS 

For purposes of the Agreement (including this Exhibit A): 

Affiliate. “Affiliate” shall mean, with respect to a Person, any other Person that directly or indirectly controls, is
controlled by, or is under common control with such first Person. For the purpose of this definition, “control” (including, with correlative meaning, the terms “controlled by” and “under the common control”) meaning
direct or indirect ownership of fifty percent (50%) or more, including ownership by trusts with substantially the same beneficial interests, of the voting and equity rights of such Person, or the power to direct the management of such
Person. 
 Agreement. “Agreement” shall mean the Asset Purchase Agreement (including the Disclosure Schedule), to
which this Exhibit A is attached as it may be amended from time to time. 
 Annual Net Sales. “Annual Net
Sales” shall mean the gross amount invoiced by Purchaser, its Affiliate and its sublicensees, for sales of the Product to a third party within a single calendar year, less the following deductions, to the extent accrued and directly allocable
to the Product: 
 (a) cash discounts; 

(b) returns (including recalls); price protection and shelf stock adjustments; reprocurement charges by customers and other similar charges;
chargebacks, allowances, discounts, and rebates; 
 (c) other payments required by applicable Legal Requirements or agreed to be made under
Medicaid, Medicare or other government special medical assistance programs (including, but not limited to, payments made under the new “Medicare Part D Coverage Gap Discount Program” and the “Annual Fee on Branded Prescription
Pharmaceutical Manufacturers”); 
 (d) relevant managed markets rebates; and 

(e) sales, excise or other similar taxes (excluding income taxes). 

For clarity, any subsequent adjustment to an accrual shall be reflected in the Annual Net Sales in the period in which such adjustment is
made. Sales between Purchaser and its Affiliates shall be disregarded for purposes of calculating Annual Net Sales except if such Affiliates are end users. Annual Net Sales shall be accounted for in accordance with GAAP, consistent with
Purchaser’s books and records, and in any event consistent with all of its other branded pharmaceutical products. 
 Business.
“Business” shall all activity related to Sellers’ development, ownership and use of the Designated Assets. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 19 of 38 

 Commercially Reasonable Efforts. “Commercially Reasonable Efforts shall mean that
level of efforts and resources, with respect to a particular Party, at the relevant point in time, that is consistent with the usual practice followed by a similarly situated company, in the exercise of its reasonable scientific and business
judgment relating to other prescription pharmaceutical products owned or licensed by it or to which it has exclusive rights, which have market potential and are at a stage of development or product life similar to the applicable Product, taking into
account measures of patent coverage, length of any statutory period of exclusivity, relative safety and efficacy, product profile, the competitiveness of the marketplace, the proprietary position of the compound or product, the regulatory structure
involved, the relative profitability of the products (including, without limitation, pricing and reimbursement status) and other relevant factors, including without limitation comparative technical, legal, scientific, and/or medical factors.

 Competitive Activity. “Competitive Activity” shall mean the research or development of, sale, testing, marketing,
commercialization or offer of the Product or any product or service that competes with the Product or that could be developed and commercialized for the same indications as the Product. 

Damages. “Damages” shall mean any loss, damage, injury, decline in value, Liability, lost opportunity, claim, settlement,
judgment, fine, penalty, tax, fee (including any reasonable legal fee), charge or expense of any nature. 
 Disclosure
Schedule. “Disclosure Schedule” shall mean the disclosure schedule delivered by Sellers to Purchaser contemporaneously with the execution and delivery of the Agreement. 

Equity Documents. “Equity Documents” shall mean the documents to be executed by the other purchasers in the Financing.

 Encumbrance. “Encumbrance” shall mean any lien, pledge, hypothecation, charge, mortgage, security interest,
encumbrance, equity, trust, equitable interest, claim, preference, right of possession, lease, tenancy, license, encroachment, covenant, infringement, interference, Order, proxy, option, right of first refusal, preemptive right, community property
interest, legend, defect, impediment, exception, reservation, limitation, impairment, imperfection of title, condition or restriction of any nature (including any restriction on the transfer of any asset, any restriction on the receipt of any income
derived from any asset, any restriction on the use of any asset and any restriction on the possession, exercise or transfer of any other attribute of ownership of any asset). 

GAAP. “GAAP” shall mean United States generally accepted accounting principles and practices in effect from time to time,
consistently applied. 
 Knowledge. Information shall be deemed to be known to or to the “knowledge” of the Sellers
if that information is actually known, reasonably should be known or reasonably could be expected to be discovered in the course of conducting a reasonable investigation concerning the existence of such fact or other matter by any Seller.

  
 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 20 of 38 

 Legal Requirement. “Legal Requirement” shall mean any federal, state, local,
municipal, foreign or other law, statute, legislation, constitution, principle of common law, resolution, ordinance, code, edict, decree, proclamation, treaty, convention, rule, regulation, ruling, directive, pronouncement, requirement,
specification, determination, decision, opinion or interpretation issued, enacted, adopted, passed, approved, promulgated, made, implemented or otherwise put into effect by or under the authority of any Governmental Body. 

Liability. “Liability” shall mean any debt, obligation, duty or liability of any nature (including any unknown, undisclosed,
unmatured, unaccrued, unasserted, contingent, indirect, conditional, implied, vicarious, derivative, joint, several or secondary liability), regardless of whether such debt, obligation, duty or liability would be required to be disclosed on a
balance sheet prepared in accordance with generally accepted accounting principles and regardless of whether such debt, obligation, duty or liability is immediately due and payable. 

Patents. “Patents” shall mean all patents and patent applications (including inventor’s certificates and utility models)
in any country or jurisdiction, including all provisionals, substitutions, counterparts, continuations, continuations-in-part, divisionals, supplementary protection certificates, renewals, all letters patent granted thereon, and all reissues,
reexaminations, extensions, confirmations, revalidations, registrations, patents of addition thereof, PCTs, pediatric exclusivity periods, and foreign equivalents to any of the foregoing. 

Person. “Person” shall mean any individual, corporation, partnership, limited liability company, or other legal entity or
governmental body other than Purchaser and Sellers. 
 Phase 2 Clinical Trial. “Phase 2 Clinical Trial” shall mean
any controlled human clinical trial designed to: (a) evaluate the effectiveness of the intended use of the therapeutic agent for a particular indication or indications; (b) identify short-term side effects and risks that are associated
with the therapeutic agent in the dosage range to be prescribed; and (c) satisfy the requirements of 21 CFR § 312.21(b). 

Phase 3 Clinical Trial. “Phase 3 Clinical Trial” shall mean any human clinical trial designed to: (a) establish that the
therapeutic agent is safe and efficacious for its intended use; (b) define warnings, precautions and adverse reactions that are associated with the therapeutic agent in the dosage range to be prescribed; and (c) support regulatory approval
of the therapeutic agent, that would satisfy the requirements of 21 CFR § 312.21(c). 
 Proceeding.
“Proceeding” shall mean any action, suit, litigation, arbitration, proceeding (including any civil, criminal, administrative, investigative or appellate proceeding and any informal proceeding), prosecution, contest, hearing, inquiry,
inquest, audit, examination or investigation commenced, brought, conducted or heard by or before, or otherwise involving, any governmental body or any arbitrator or arbitration panel. 

Securities Act. “Securities Act” means the Securities Act of 1933, as amended. 

Tax. “Tax” shall mean any tax (including any income tax, franchise tax, capital gains tax, estimated tax, gross receipts tax,
value-added tax, surtax, excise tax, ad valorem tax, transfer  
  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 21 of 38 

 
tax, stamp tax, sales tax, use tax, property tax, business tax, occupation tax, inventory tax, occupancy tax, withholding tax or payroll tax), levy, assessment, tariff, impost, imposition, toll,
duty (including any customs duty), deficiency or fee, and any related charge or amount (including any fine, penalty or interest), that is, has been or may in the future be (a) imposed, assessed or collected by or under the authority of any
governmental body, or (b) payable pursuant to any tax-sharing agreement or similar contract. 
 Transactional Agreements.
“Transactional Agreements” shall mean the Agreement and the Consulting Agreements, the Amendment No. 1 to License Agreement and any other documents delivered by Sellers to Purchaser to complete the transactions contemplated hereby.

 Valid Claim. “Valid Claim” shall mean a claim of any issued and unexpired Patent within the
(a) HH Patents or (b) Patents licensed under the License Agreement, as applicable, that has not been held invalid or unenforceable by a final decision of a court or governmental agency of competent jurisdiction, which decision can no
longer be appealed or was not appealed within the time allowed; provided, however, that if a claim of a pending patent application within the Patents licensed under the License Agreement, as applicable, shall not have issued within [ * ]
after the earliest filing date from which such claim takes priority, such claim shall not constitute a Valid Claim for the purposes of this Agreement. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 22 of 38 

 EXHIBITS 

FORM OF CONSULTING AGREEMENT 

CONSULTING AGREEMENT 

This Consulting Agreement (“Agreement”) is made and entered into as of September , 2015,
(“Effective Date”) by and between Eiger BioPharmaceuticals, Inc., a Delaware corporation with an address of 350 Cambridge Avenue, Suite 350, Palo Alto, CA 94306 (the “Company”), and Colleen Craig, MD
(“Consultant”), with an address of 300 Pasteur Drive, Room S025, Stanford, CA 94305. Both Company and Consultant are referred to herein, individually, as a “Party” and, collectively, as the
“Parties”. 
 WHEREAS, Company desires to retain Consultant to render consulting services to Company
and Consultant desires to be so retained by Company and to perform such services further specified herein, all in accordance with the terms and conditions of this Agreement. 

NOW, THEREFORE, in consideration of the premises, conditions and representations set forth herein, and other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged by Company and Consultant, Company and Consultant agree as follows. 
 PROFESSIONAL SERVICES

 Services. Company hereby retains Consultant to provide professional consulting services as set forth on Exhibit A (the
“Services”) to Company, which is attached hereto and incorporated herein by reference, and Consultant hereby accepts such engagement. Consultant agrees to perform for Company the professional Services and deliver to Company
the work product agreed upon by the Parties, including the time commitments, deliverables and any relevant timetables and specifications set forth on Exhibit A hereto. 

Best Efforts. Consultant will use best efforts to perform the Services hereunder for Company in a diligent, timely, and professional
manner, in accordance with specifications reasonably requested by Company. 
 Location and Access. The consulting Services
shall be performed at Consultant’s premises or such other premises that Company and Consultant may mutually agree upon. 

Payroll Taxes. Consultant will be solely responsible for paying all applicable payroll taxes of any nature, including social security
and other social welfare taxes or contributions, that may be due on amounts paid to Consultant pursuant to this Agreement. 
 PAYMENT 

Company agrees to compensate Consultant for the Services performed by Consultant pursuant to this Agreement in accordance with the payment
terms set forth in Exhibit A. Payment will be made only for work that has been performed to the reasonable satisfaction of Company. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 23 of 38 

 CONFIDENTIAL INFORMATION 

Definition. As used in this Agreement, the term “Confidential Information “ means
(i) any technical or business information furnished by Company, or on behalf of Company by its affiliates, subsidiaries, contractors, advisors, partners, or agents, to Consultant in connection with the Services to be performed hereunder,
(ii) any work product produced by Consultant as a result of work hereunder, as well as all work papers related thereto, regardless of whether such information is specifically designated as confidential and regardless of whether such information
is in written, oral, electronic or other form, and (iii) Data and Inventions (as defined in Section 4.1 hereof). 

Use and Non-disclosure. Consultant acknowledges that, in the course of performing or preparing to perform Services for Company under
this Agreement, Consultant will become acquainted with certain of Company’s Confidential Information, the protection of which is necessary to the successful conduct of Company’s business and the preservation of the integrity of
Company’s relationships with its customers. Company will make a reasonable effort to mark media containing Confidential Information with notice of the same and, otherwise, to inform Consultant when the latter is provided, or given access to,
Confidential Information. Consultant agrees to (i) maintain all Confidential Information in strict confidence; (ii) use all Confidential Information solely for the purposes of performing Consultant’s obligations under this Agreement;
and (iii) reproduce the Confidential Information only to the extent necessary to perform Consultant’s obligations under this Agreement, with all such reproductions being considered Confidential Information. Consultant shall not disclose
Confidential Information to any third party without Company’s express written authorization. 
 Exceptions. The foregoing
obligations of Consultant shall not apply to any Confidential Information that Consultant can demonstrate: (i) was already in the public domain prior to the time of its disclosure under this Agreement; (ii) entered the public domain
through means other than an unauthorized disclosure resulting from an act or omission by Consultant; (iii) was independently developed or discovered by Consultant prior to the time of its disclosure under this Agreement, as evidenced by
Consultant’s written records; (iv) is or was disclosed to Consultant at any time, whether prior to or after the time of its disclosure under this Agreement, by a third party having no fiduciary relationship with Company and having no
obligation of confidentiality with respect to such Confidential Information; or (v) is required to be disclosed to comply with applicable laws or regulations, or with a court or administrative order, provided that Company receives prior written
notice of such disclosure and that Consultant takes all reasonable and lawful actions to obtain or to permit Company to obtain confidential treatment for such disclosure and, if possible, to minimize the extent of such disclosure. 

No License. Consultant acknowledges that, as between Consultant and Company, Company is the sole owner of the Confidential Information
disclosed by Company and all patent, copyright, trademark, trade secret, and other intellectual property rights in, or arising from, such Confidential Information or developed hereunder. No option, license, or conveyance of such rights to Consultant
is granted or implied under this Agreement. 
  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 24 of 38 

 OWNERSHIP OF WORK PRODUCT 

Invention Disclosure. Consultant agrees to disclose promptly and in writing to Company any and all data, ideas, concepts, discoveries,
inventions (whether patentable or not), developments, original works of authorship, trade secrets, and know-how that are developed, conceived, devised, invented, developed or reduced to practice or tangible medium by Consultant, under her direction
or jointly with others, which arise from or in connection with this Agreement (“Data and Inventions “). All work products hereunder shall be “work for hire”, and Consultant shall have no interest in
the Data and Inventions. 
 Assignment. Consultant hereby assigns to Company all of Consultant’s right, title, and
interest to the Data and Inventions and any and all related patent rights, copyrights, and applications and registrations therefor. During the Term (as defined in Section 8.1) and thereafter, Consultant shall cooperate with Company, at
Company’s expense, in obtaining proprietary protection for the Data and Inventions, and shall execute all documents which Company shall reasonably request to perfect Company’s rights in the Data and Inventions. Consultant acknowledges and
agrees that without Company’s substantial investment of time and money, the Data and Inventions could not be developed. In the event that any Data or Invention cannot be assigned to Company as sole owner, and Consultant retains some right to
use Data or Inventions, then Consultant agrees only to use the same only for internal, noncommercial research. 
 CONSULTANT REPRESENTATION,
WARRANTIES, AND CERTAIN COVENANTS 
 Consultant represents, warrants, and covenants to Company throughout the Term as follows. 

The execution and performance of this Agreement does not, and will not, constitute a breach or default under any contract to which Consultant
is a party, or by which Consultant is bound, and Consultant is not, and shall not be, under any contractual or other obligation to any third party which conflicts with any obligations hereunder or prevents or limits the performance of Services under
this Agreement. 
 Consultant is free to disclose to Company, without breach of any obligation to a third party, any and all information,
ideas, suggestions, developments, or know-how that Consultant may develop, generate or otherwise create in performing the Services under this Agreement. 

Consultant has complied and will comply with all applicable laws, rules, regulations, and guidelines in her conduct of the Services under this
Agreement. 
 Consultant warrants and represents that Consultant is not now, nor has Consultant ever been debarred or disqualified as a
clinical investigator or participant in clinical services by the United States Food and Drug Administration or by any other regulatory or governmental authority. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 25 of 38 

 Consultant further warrants and represents that Consultant has no knowledge of any circumstances
which may affect the accuracy of the foregoing. Consultant agrees to notify Company immediately if such party becomes aware of any change in circumstances that would render any of the foregoing untrue or misleading in any respect during the Term.

 SOLICITATION OF COMPANY EMPLOYEES 

Consultant agrees that during the Term and for a period of [ * ] thereafter, Consultant shall not, without Company’s prior written
consent, recruit, solicit, or hire any employee of Company, or induce or attempt to induce any employee of Company to discontinue his or her employment relationship with Company. 

INDEMNIFICATION 
 Indemnification of
Consultant. Company shall indemnify and hold harmless each of Consultant and its affiliates, and the successors and assigns of any of the foregoing (the “Consultant Indemnitees “), from and against any and
all losses, liabilities, damages, penalties, fines, costs and expenses (including reasonable attorneys’ fees and other expenses of litigation) (“Losses”) from any claims, actions, suits or proceedings
brought by a third party (a “Third Party Claim”) incurred by any Consultant Indemnitee, arising from, or occurring as a result of (a) gross negligence or willful misconduct of Company and its Affiliates and
(b) the research, development and regulatory activities relating to the exendin product conducted by or on behalf of Company in connection with the performance of the Services in accordance with this Agreement; except to the extent such Third
Party Claims fall within the scope of the indemnification obligations of Consultant set forth in Section 7.2. 
 Indemnification
of Company. Consultant shall indemnify and hold harmless each of Company and its Affiliates and the directors, officers, shareholders, employees and agents of such entities and the successors and assigns of any of the foregoing (the
“Company Indemnitees “), from and against any and all Losses from any Third Party Claims incurred by any Company Indemnitee, arising from, or occurring as a result of (a) gross negligence or willful
misconduct of Consultant or its Affiliates; and (b) any material breach of any representations, warranties or covenants by Consultant under this Agreement, except to the extent such Third Party Claims fall within the scope of the
indemnification obligations of Company set forth in Section 7.1(a) or (b). 
 Procedure. A
Party that intends to claim indemnification (the “Indemnified Party”) under this Section 7 shall promptly notify the indemnifying Party in writing of any Third Party Claim, in respect of which the Consultant Indemnitee
or Company Indemnitee, as the case may be, intends to claim such indemnification. The Indemnified Party shall provide the Indemnifying Party with reasonable assistance, at the indemnifying Party’s expense, in connection with the defense of the
Third Party Claim for which indemnity is being sought. The indemnitee may participate in and monitor such defense with counsel of its own choosing at its sole expense; provided, however, the indemnitor shall have
the right to assume and conduct the defense of the Third Party Claim with counsel of its choice. The indemnitor shall not settle any Third Party Claim without the prior written consent of the Indemnified Party, not to be unreasonably 

  
 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 26 of 38 

 
withheld, unless the settlement involves only the payment of money. So long as the indemnitor is actively defending the Third Party Claim in good faith, the indemnitee shall not settle any such
Third Party Claim without the prior written consent of the Indemnifying Party. If the Indemnitor does not assume and conduct the defense of the Third Party Claim as provided above, (a) the indemnitee may defend against, and consent to the entry
of any judgment or enter into any settlement with respect to the Third Party Claim in any manner the indemnitee may deem reasonably appropriate, and (b) the indemnitor will remain responsible to indemnify the Indemnitee as provided in this
Section 7. The failure to deliver written notice to the Indemnitor within a reasonable time after the commencement of any action with respect to a Third Party Claim shall only relieve the indemnitor of its indemnification obligations under this
7. if and to the extent the indemnitor is actually prejudiced thereby. 
 TERM AND TERMINATION 

Term. This Agreement shall be effective for the period set forth in Exhibit A hereof (the “Term”). 

Termination. This Agreement may be terminated (i) by either Party at any time in the exercise of its sole discretion upon [ * ]
written notice to the other Party, (ii) by a Party upon the material breach of this Agreement by the other Party, which material breach continues unremedied for [ * ] after delivery to the breaching Party by the nonbreaching Party of notice of
material breach, (iii) by a Party immediately in the event of bankruptcy (voluntary or otherwise), insolvency, or other similar financial distress of the other Party. 

Return of Company Materials. Upon expiration or termination of this Agreement for any reason or at any time upon request by Company,
Consultant will immediately return to Company all property belonging to Company, including without limitation all Confidential Information and Data and Inventions in Consultant’s possession or control. 

Survival. Termination or expiration of this Agreement shall not cancel or terminate any rights and/or obligations which arose prior to
the effective date of termination or expiration and which must continue in order to give effect to their meaning at the time such right and/or obligation arose, including without limitation Sections 3 4, 7, 8.3, 8.4, 10 and 12. 

NOTICES 
 Any notice or approval required or
permitted under this Agreement will be delivered in writing and will be sent by (i) facsimile (followed by a copy sent by overnight courier or, if the delivery is international, by two-day courier) or (ii) by overnight courier or, if the
delivery is international, by two-day courier to the address specified below or to any other address that may be designated by prior notice. Any notice or approval delivered by facsimile will be deemed to have been delivered the day it is sent,
unless it arrives after 5:00 p.m. at the recipient address or on a day other than a business day at the recipient address, in which case it shall be deemed delivered on the next business day. Any notice or approval sent by courier will be deemed
delivered on the next business day after its date of posting if domestic or two business days after the day of posting if international. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 27 of 38 

					
		 	If to Company:	  	If to Consultant:
			
		 	 Eiger BioPharmaceuticals, Inc.
 350 Cambridge
Avenue, Suite 350
 Palo Alto, CA 94306
 Attn: Matthew Bys

Telephone: 415-203-0934
 Email: mbvs@eigerbio.com
	  	 Colleen Craig, MD
 300 Pasteur Drive, Room
S025
 Stanford, CA 94305
 Attn: Colleen Craig, MD

Telephone: 650-350-2153
 Email: cmcraig@stanford.edu

 NON-COMPETITION 

Consultant hereby covenants, acknowledges and agrees that it will not, at any time during [ * ] from the Effective Date, either directly or
indirectly, as principal, agent, owner, partner, employee, consultant, shareholder, director or officer, as the case may be, in any manner whatsoever, own, be engaged in, be concerned with, be interested in, operate, have any financial interest in
or advance, lend money to, guarantee the debts or obligations of, permit its name or any part thereof to be used or applied by any person, firm or corporation engaged in or concerned with or interested in, directly or indirectly, in any competitive
activity in any territory in which the exendin products are currently planned to be commercialized, except as a passive shareholder holding less than [ * ] percent of the outstanding shares of a corporation offering its shares to the public and
whose shares are listed and posted for trading on a recognized stock exchange. Notwithstanding the foregoing covenant, Company agrees that said covenant shall not be construed to preclude Consultant from continuing, during said [ * ] period
following the Effective Date, their research and mechanistic studies relating to hyperinsulinemic hypoglycemia in connection with their employment at Stanford (as defined below). 

CONSULTANT’S OBLIGATIONS SUBJECT TO THE EMPLOYMENT TERMS AND POLICIES OF STANFORD 

Company acknowledges that it is aware that Consultant is a full time employee of the Leland Stanford Junior University
(“Stanford”), and that under Stanford’s employment terms and policies, it is permissible for Consultant to provide the Services desired by Company under this Agreement; provided, however, in the
event of a conflict between Stanford’s employment terms and policies and Consultant’s obligations hereunder, Stanford’s employment terms and policies shall govern, it being agreed that the parties shall in good faith attempt to amend
this Agreement to reflect the intent of the parties with respect to the conflicting provision. In this connection, for example, Company acknowledges that it is aware that Stanford currently limits outside consulting services by its employees to a
maximum of eight (8) hours per week. 
 GENERAL 

Entire Agreement. This Agreement embodies the entire agreement and understanding between the Parties with respect to the subject matter
hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 28 of 38 

 Modifications and Amendments. The terms and provisions of this Agreement may be modified
or amended only by written agreement executed by the Parties hereto. 
 Waivers and Consents. The terms and provisions of this
Agreement may be waived, or consent for the departure therefrom granted, only by written document executed by the Party entitled to the benefits of such terms or provisions. No such waiver or consent shall be deemed to be or shall constitute a
waiver or consent with respect to any other terms or prov1s1ons of this Agreement, whether or not similar. 
 Assignment.
Company may assign its rights and obligations hereunder to any person who or entity which succeeds to all or substantially all of Company’s business or that aspect of Company’s business in which Consultant is principally involved.
Consultant’s rights and obligations under this Agreement may not be assigned without the prior written consent of Company. 

Benefit. All statements, representations, warranties, covenants, and agreements in this Agreement shall be binding on the Parties
hereto and shall inure to the benefit of their respective successors and permitted assigns. Nothing in this Agreement shall be construed to create any rights or obligations except among the Parties hereto, and no person or entity shall be regarded
as a third party beneficiary of this Agreement. 
 Headings and Captions. The headings and captions of the various
subdivisions of this Agreement are for convenience of reference only and shall in no way modify, or affect the meaning or construction of, any of the terms or provisions hereof. 

No Waiver of Rights, Powers, and Remedies. No failure or delay by a Party hereto in exercising any right, power or remedy under this
Agreement, and no course of dealing between the Parties hereto, shall operate as a waiver of any such right, power or remedy of the Party. No single or partial exercise of any right, power or remedy under this Agreement by a Party hereto, nor any
abandonment or discontinuance of steps to enforce any such right, power or remedy, shall preclude such Party from any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. The election of any remedy by a
Party hereto shall not constitute a waiver of the right of such Party to pursue other available remedies. No notice to or demand on a Party not expressly required under this Agreement shall entitle the Party receiving such notice or demand to any
other or further notice or demand in similar or other circumstances or constitute a waiver of the rights of the Party giving such notice or demand to any other or further action in any circumstances without such notice or demand. 

Independent Contractor. Company and Consultant agree that the relationship of Consultant to Company is at all times that of an
independent contractor and not that of an employee, partner or joint-venturer of or with Company. 
 Counterparts. This
Agreement may be executed in one or more counterparts that together shall constitute one and the same legal instrument. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 29 of 38 

 Governing Law. This Agreement and the rights and obligations of the Parties hereunder
shall be construed in accordance with and governed by the laws of the State of California, without giving effect to the conflict of law principles thereof. 

Jurisdiction and Service of Process. Any legal action or proceeding with respect to this Agreement shall be brought in the state and
Federal courts in the City of San Francisco, California. By execution and delivery of this Agreement, each of the Parties hereto accepts for itself and in respect of its property, generally and unconditionally, the jurisdiction of the aforesaid
courts. Each of the Parties hereto irrevocably consents to the service of process of any of the aforementioned courts in any such action or proceeding by the mailing of copies thereof by certified mail, postage prepaid, to the party at its address
set forth in Section 9 hereof. 
 Severability. The Parties intend this Agreement to be enforced as written. However,
(i) if any portion or provision of this Agreement shall to any extent be declared illegal or unenforceable by a duly authorized court having jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in
circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law; and
(ii) if any provision, or part thereof, is held to be unenforceable because of the duration of such provision or the geographic area covered thereby, the Parties agree that the court making such determination shall have the power to reduce the
duration and/or geographic area of such provision, and/or to delete specific words and phrases, and in its reduced form such provision shall then be enforceable and shall be enforced. 

Subcontracting. All services or materials for which Consultant contracts, subcontracts, or purchases for purposes of this Agreement
shall be subject to prior written approval by Company. Consultant agrees to provide to Company a copy of any such contract for services or materials prior to execution for comment, in particular regarding costs, source, payment schedule, early
termination penalties, confidentiality, and patent rights. Consultant hereby unconditionally guarantees the timely performance of Services and delivery of deliverables in accordance with this Agreement by any affiliate or permitted subcontractor
hereunder. 
 Injunctive Relief. Consultant acknowledges that breach of Consultant’s covenants contained in
Section 3 or Section 10 may cause irreparable harm to the Company, which may not be compensable through monetary damages. Consultant therefore hereby acknowledges that in the event of a breach or a threatened breach by the them or their
respective affiliates of such covenants, the Company will be entitled, in addition to any other rights, remedies or damages which may be available to Company, at law or in equity, to obtain an interim and permanent injunction in order to prevent or
restrain any breach or threatened breach of this Agreement by Consultant or their affiliates, partners, employers, employees, servants, agents, representatives, and other persons directly or indirectly acting for, or on behalf of, or with,
Consultant. Consultant further agree that the Company shall be entitled to injunctive relief without having to prove damages and shall be entitled to all of its costs and expenses incurred in order to obtain relief from any such breach under this
Agreement 
  
 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 30 of 38 

 IN WITNESS WHEREOF, the Parties the parties hereto have executed this Consulting Agreement on the
Effective Date written above. 
 Eiger BioPharmaceuticals, Inc. 
  

			
	By:	 	  

		 	David A. Cory
		 	Chairman, President and CEO, Eiger BioPharmaceuticals
	
	CONSULTANT:
		
	By:	 	  

	Name:	 	Colleen Craig, MD

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 31 of 38 

 Exhibit A 
  

	1.	Services and Documentation. 

 CONSULTANT’S SERVICES MAY INCLUDE: (I) PROVIDING
CONSULTATIVE SERVICES SURROUNDING THE EXENDIN DEVELOPMENT AND CLINICAL PROGRAM; (II) SPEAKING WITH INVESTORS, BANKS AND OTHER OUTSIDE PARTIES REGARDING THE EXENDIN DEVELOPMENT AND CLINICAL PROGRAM; AND (III) OTHER SERVICES AS MUTUALLY AGREED.
CONSULTANT SHALL BE AVAILABLE, SUBJECT TO RECEIVING REASONABLE NOTICE FROM COMPANY, FOR MEETINGS TO PARTICIPATE AND FACILITATE COMMUNICATION AND WORK FLOW. 
  

	2.	Term. 

 This Agreement shall be effective for the period beginning on the Effective Date
and shall continue in full force for one (1) year thereafter, unless earlier terminated as permitted herein. This Agreement shall automatically renew for an annual period thereafter unless either Party provides written notice not less than [ *
] days prior to the then applicable annual expiration date. 
  

	3.	Fees. 

 Consultant shall be paid [ * ] the first month for the value of her Services
associated with the transfer of information, documents, and know-how related to the Exendin development and clinical program into the Company, and then the Consultant shall be paid at the rate of [ * ] per month for the remaining eleven
(11) months of the first year of the Term, for time spent by Consultant on providing consulting Services requested by Company. In the interest of clarity, it is understood and agreed that Consultant will be paid said monthly amount for being
available to provide Services reasonably requested by Company, regardless of whether, or the extent to which, Company requests Services. After the first anniversary, the fees shall paid on a per hour basis on actual consulting services time provided
to the Company at the rate of [ * ] per hour. 
 It is further understood and agreed that if this Agreement is terminated during the initial
year of the Term for any reason, the monthly amount due and payable to Consultant for the month in which such termination occurs will be appropriately pro-rated. 
  

	4.	Payment Terms. 

 Company shall pay consultant on a monthly basis at the end of each
month. Company will reimburse Consultant for any reasonable, authorized travel, lodging and other out-of-pocket expenses incurred by personnel in the course of performing hereunder, provided that Consultant furnishes Company with specific
documentation therefore and Company approves all such expenses in advance. 
  
 [ * ]
= CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS,
IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 32 of 38 

 All invoices for the above-described out-of-pocket expenses shall be submitted by Consultant
directly to Company. Payment of all undisputed amounts shall be made within [ * ] days after receipt of invoice by Company. If Company has a dispute with any charges set forth in an invoice, Company shall notify Consultant of the dispute and provide
Consultant details of the dispute. The Parties shall negotiate in good faith to promptly resolve disputes related to any invoiced amounts. Consultant shall maintain records of all time and expenses under this Agreement and shall provide Company
reasonable access to the same upon request. 
  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 33 of 38 

 EXHIBIT C 

AMENDMENT NO. 1 TO LICENSE AGREEMENT 

AMENDMENT NO. 1 TO LICENSE AGREEMENT 

This Amendment No. 1 to License Agreement (the “Amendment”) is effective as of
            day of September 2015 (the “Amendment Effective Date”), and amends that certain License Agreement effective May 4, 2015 (the
“Agreement”) among The Board of Trustees of the 
 Leland Stanford Junior University
(“Stanford”), an institution of higher education having powers under the laws of the State of California, and Tracey McLaughlin and Colleen Craig (the “Original Licensees”), individuals having a
principal place of business at Stanford University School of Medicine, and Eiger BioPharmaceuticals, Inc. (“Eiger”), as assignee of the Original Licensees pursuant to this Amendment. Collectively, Stanford, Original Licensees
and Eiger are referred to as the “Parties”. 
 RECITALS 

 

	 	A.	The Original Licensees are assigning to Eiger all but certain specified rights and interests in technology with respect to Exendin for any and all uses, including the technology described within Stanford Docket S12-372
under the License Agreement; 

  

	 	B.	Eiger desires to become assignee of the Original Licensees as set forth in this Amendment in order to further develop Exendin; and 

  

	 	C.	Stanford desires to accept Eiger as an assignee of the Original Licensees and to amend Sections 1 and 13 of the Agreement as set forth in this Amendment. 

AGREEMENT 
 Now, therefore, for
good and valuable consideration, the receipt of which the parties acknowledge, the parties hereby agree as follows: 
  

	 	1.	Upon the Amendment Effective Date, the Agreement shall be amended as follows: 

  

	 	a.	Eiger shall replace and be deemed the sole Licensee and assume all of the rights and obligations under the Agreement, and the Original Licensees shall have no rights or obligations under the Agreement.

  

	 	b.	Within [ * ] days after the Amendment Effective Date, Eiger shall pay to Stanford [ * ] to an account designated by Stanford. 

  

	 	c.	Section 1 of the Agreement is amended to add the following clause to the end of the first sentence: 

  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 34 of 38 

 “, including one or more provisional applications to be filed by Licensee at Licensee’s
discretion between the Amendment Effective Date and the date a PCT patent application claiming priority to Serial No. [ * ] is filed, the PCT application, and any US or foreign patents that issue on or claim priority to any of the foregoing.”

  

	 	d.	Section 13 of the Agreement is hereby amended and restated to read in its entirety as follows: 

“13. Assignment. 

13.1 Permitted Assignment by Licensee. Subject to Section 13.3, Licensee may assign this Agreement: (a) as part of a sale or
change of control, regardless of whether such a sale or change of control occurs through an asset sale, stock sale, merger or other combination, or any other transfer of Licensee’s entire business or that part of Licensee’s business that
exercises all rights granted under this Agreement; 
 or 

(b) to an Affiliate provided that Licensee remains liable to Stanford for the performance by its Affiliate. 

13.2 Any Other Assignment by Licensee. Except pursuant to Section 13.1, any attempt to assign this Agreement by Licensee without
Stanford’s prior written consent is null and void. 
 13.3 Conditions of Assignment. Prior to any assignment, the following conditions
must be met: 
 (a) Licensee must make best efforts to give Stanford [ * ] prior written notice of the assignment, including the new
assignee’s contact information; and 
 (b) the new assignee must agree in writing to Stanford to be bound by this Agreement; and 

(c) Stanford must have received a [ * ] assignment fee. 

13.4 After the Assignment. Upon a permitted assignment of this Agreement pursuant to this Section 13, Licensee will be
released of liability under this Agreement and the term “Eiger” in this Amendment and “Licensee” in the Agreement will mean the assignee.” 

 

	 	2.	Stanford and the Original Licensees each represent and warrant to Eiger the following: 

  

	 	a.	as of the Amendment Effective Date, the Agreement remains in full force and effect; 

  

	 	b.	no notice of any termination, noncompliance or breach has been delivered or received by either of Stanford or Original Licensees; and 

 

	 	c.	none of Stanford or the Original Licensees is aware of noncompliance or claim that would result in a breach or termination of the Agreement. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 35 of 38 

	 	3.	Except as expressly set forth herein, the Agreement remains in full force and effect and shall not otherwise be amended except in writing entered into by Eiger (as Licensee) and Stanford. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 36 of 38 

 In witness whereof, the Parties hereto have executed and delivered this Amendment in their
personal capacity or through their duly authorized officers or representatives, as the case may apply. 
  

					
		 	Stanford:
		
		 	The Board of Trustees of the Leland Stanford Junior University
		
		 	Signature:
                                         
                                       
		
		 	Name:
                                         
                                         
    
		
		 	Title:
                                         
                                         
      
		
		 	Original Licensees (with respect to the Amendment and as assignors):
		
		 	Signature:
                                         
                                       
		 	                                    
Tracey McLaughlin
		
		 	Signature:
                                         
                                       
		 	                                    
Colleen Craig, M.D.
		
		 	Eiger:
		
		 	Eiger BioPharmaceuticals, Inc.
		
		 	Signature:
                                         
                                       
		
		 	Name:
                                         
                                         
      
		
		 	Title:
                                         
                                         
      

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 37 of 38 

 EXHIBIT D 

CAPITALIZATION TABLE 
  

			
	 Security Type
	  	Shares
	[*]	  	[*]
	[*]	  	[*]
	[*]	  	[*]
	[*]	  	[*]
		  	  

	[*]	  	[*]

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 38 of 38EX-10.47

 Exhibit 10.47 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
  

 
 ASSET PURCHASE AGREEMENT 

among: 
 EIGER
BIOPHARMACEUTICALS, INC. 
 a Delaware corporation; 

and 

EICCOSE, LLC, 

a Delaware limited liability company 
  

 
 Dated as of
October 29, 2015 
  
  

 
  

 

 ASSET PURCHASE AGREEMENT 

THIS ASSET PURCHASE AGREEMENT is entered into as of
October 29, 2015, by and between EIGER BIOPHARMACEUTICALS, INC., a Delaware corporation (“Purchaser”) and EICCOSE, LLC, a Delaware limited
liability company (“Seller”). Purchaser and Seller are referred to herein collectively as the “Parties” and individually as a “Party.” Certain other
capitalized terms used in this Agreement are defined in Exhibit A. For clarity, Purchaser shall include any assignee, successor-in-interest or remaining entity possessing the Designated Assets (as defined below) in the event of any merger,
reorganization or other similar acquisition transaction. 
 RECITALS 

A. Purchaser and Seller wish to provide for the sale by Seller to Purchaser of the Designated Assets (as defined in Section 1.1)
by Purchaser on the terms and subject to the conditions set forth in this Agreement. 
 B. This Agreement has received the
requisite corporate approval by Purchaser and Seller. 
 AGREEMENT 

The Parties, intending to be legally bound, agree as follows: 

SECTION 1. SALE OF DESIGNATED ASSETS; RELATED
TRANSACTIONS. 
 1.1 Sale of Designated Assets. Seller hereby sells and assigns to Purchaser
the entirety of their right, title and interest in and to the Designated Assets on the terms and subject to the conditions set forth in this Agreement. The “Designated Assets” shall mean the following assets: 

(a) All rights and interests in and to Patents, copyrights, trademarks, trade secrets, know-how, inventions, trade secrets and all other
proprietary information, whether patentable or unpatentable and whether or not reduced to practice, and documentation and related applications related to Stanford Docket S11-438 - Pulmonary Arterial Hypertension (“PAH”) and Stanford
Docket S14-323 – Lymphedema, consisting principally of the license agreements to be assigned pursuant to Sections 1.1(d), (e) and (f) below; 

(b) All techniques, technology, trade secrets, inventions (whether patentable or not), methods, know-how, data and results (including
pharmacological, toxicological and clinical data and results), analytical and quality control data and results, regulatory documents including investigational new drug applications (“INDs”), as well as other information related to
Bestatin (ubenimex) and its uses in the possession of Seller; 
 (c) All rights to techniques, technology, trade secrets,
inventions (whether patentable or not), methods, know-how, data and results (including pharmacological,  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 2 of 29 

 
toxicological and clinical data and results), analytical and quality control data and results, regulatory documents including INDs and correspondence, as well as other information related to
Bestatin (ubenimex) and its uses in the possession of Seller; 
 (d) The license agreement with the Board of Trustees of the Leland
Stanford Junior University (“Stanford”) dated May 1, 2015 (the “PAH License Agreement”); 

(e) The license agreement with Nippon Kayaku dated May 1, 2015 (the “Nippon Kayaku License Agreement”); and

 (f) The license agreement with the Board of Trustees of the Leland Stanford Junior University dated October 27, 2015, (the
“Lymphedema License Agreement”, together with the PAH License Agreement and the Nippon Kayaku License Agreement, the “License Agreements”). 

1.2 Purchase Price. The purchase price for the Designated Assets shall be (the “Purchase Price”): 

(a) Payment of $119,672.88 representing reimbursement of certain previously incurred expenses as set forth on Schedule 1.2,
including payments and accrued amounts owed to The Leland Stanford University in connection with the Lymphedema License Agreement and the PAH License Agreement. 

(b) At the closing of the next round of financing pursuant to which Purchaser sells shares of its Preferred Stock (or if there is no
Preferred Stock, then Common Stock) resulting in gross proceeds to the Company of at least $25,000,000, Purchaser will issue to Seller that number of fully vested shares of Purchaser’s Common Stock equal to 1.75% of the total number of the
Company’s outstanding capital stock (excluding all unissued shares available for issuance under Purchaser’s 2009 Equity Incentive Plan) as of the business day immediately following the first closing of such financing (the
“Shares”), assuming that all of the closings in such financing (if multiple closes are contemplated) have occurred; 

(c) A one-time payment of [ * ], as reasonably verified by Purchaser’s Board of Directors, which good faith determination shall be
final; 
 (d) A one-time payment of [ * ], as reasonably verified by Purchaser’s Board of Directors, which good faith
determination shall be final; and 
 (e) Following the First Commercial Sale of any Product, payments equal to [ * ] of the annual Net
Sales of each Product during each calendar year (the “Royalty Payment”). The amount of Royalty Payment payable with respect to any calendar quarter shall be calculated by Purchaser by the [ * ] following the end of a calendar
quarter (i.e, April, July, October and January) and paid within [ * ] thereafter. Payment of the royalties shall be calculated in accordance with U.S. Generally Accepted Accounting Principles and a report showing the gross sales and calculation of
Net Sales shall accompany each such quarterly payment. 
  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 3 of 29 

 1.3 Audit; Inspection. For a period of [ * ] following receipt of a Royalty Payment,
Seller shall have the right, upon written request to Purchaser, to conduct reasonable inspection and audit of Purchaser’s relevant books and records for the sole purpose of verifying the accuracy of Royalty Payments, provided that:
(i) Purchaser shall receive reasonable advance notice of such request; (ii) such inspection or audit shall take place during Purchaser’s regular business hours and at the place where such books and records are maintained;
(iii) Purchaser may demand that the Seller (and/or its agents and representative) execute a nondisclosure agreement in a form reasonably satisfactory to Purchaser prior to such inspection or audit; and (iv) in no event shall Purchaser be
required to provide access to information that is subject to attorney-client privilege. Any such inspection or audit by Seller shall be no more frequent than once per year and at its sole expense, provided, however, that if any audit indicates an
underpayment or underreporting of royalties of more than 5%, then Buyer shall pay the cost of the audit for that year not to exceed [ * ], and any unpaid royalties in arrears with interest. 

1.4 Assumed Liabilities. Purchaser shall not assume any Liabilities of Seller (whether or not related to the Designated Assets) other
than (a) Liabilities as set forth on Schedule 1.4, including accrued amounts payable under the License Agreements; and (b) obligations under the License Agreements solely to the extent arising after the Closing Date and not relating to any
breach or violation of any of the License Agreements prior to the Closing. 
 1.5 Transfer Taxes; Delivery of Assets.

 (a) Seller shall be liable for any sales Taxes, use Taxes, transfer Taxes or similar Taxes, charges or fees that may become
payable in connection with the sale of the Designated Assets to Purchaser. Purchaser and Seller shall cooperate to reduce the amount of such Taxes to the extent permitted by applicable law. 

(b) Seller shall deliver to Purchaser physical possession of all of the Designated Assets which are tangible assets no later than thirty
(30) days following the Closing. 
 1.6 Allocation. The consideration referred to in Section 1.2 shall be
allocated among the Designated Assets as set forth on a purchase price allocation scheduled proposed by Purchaser and reasonably acceptable to Seller delivered within [ * ] following the Closing, and neither of the Parties shall file any tax return
or other document with, or make any statement or declaration to, any governmental body that is inconsistent with such allocation, except as required by applicable law. 

1.7 Closing. 

(a) The closing of the sale of the Designated Assets to Purchaser (the “Closing”) shall take place concurrently with
the execution and delivery of this Agreement (the “Closing Date”). 
 (b) At the Closing: 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 4 of 29 

 (i) Seller shall execute and deliver to Purchaser: (x) recordable assignment
agreements with respect to the Patents included in the Designated Assets; and (y) such bills of sale, endorsements, assignments, and other documents as the Purchaser may determine to be necessary or appropriate to assign, convey, transfer and
deliver to the Purchaser good and valid title to the Designated Assets free and clear of any Encumbrances; and  
 (ii) Seller
shall deliver to Purchaser evidence reasonably satisfactory to Purchaser that all consents, approvals and authorizations from any Governmental Authority or from any other third party that are necessary to consummate the transactions contemplated
herein have been obtained. 
 (iii) Seller shall deliver to Purchaser evidence that the License Agreements have each been
properly assigned to Purchaser and all consents, approvals or authorizations necessary for such assignment have been obtained. 
 SECTION 2.
REPRESENTATIONS AND WARRANTIES OF SELLER. 

Seller represents and warrants to Purchaser that, except as set forth in the Disclosure Schedule (it is hereby agreed that any information
disclosed in any section or subsection of the Disclosure Schedule shall be deemed to relate to and qualify only the corresponding numbered or lettered section or subsection of this Agreement and any other section or subsection to the extent it can
be readily understood from reading such Disclosure Schedule (without any additional knowledge) that such disclosure would be applicable to such other sections or subsections): 

2.1 Due Organization; No Subsidiaries. Seller is a company duly organized, validly existing and in good standing under the laws of the
State of Delaware. Seller has no subsidiaries. The Business has historically been conducted solely by Seller. 
 2.2 Legal
Proceedings. There is no claim, lawsuit or other legal proceeding pending or, to the Seller’s knowledge, threatened against Seller that involves the Designated Assets. 

2.3 Compliance with Law; Permits. Seller has conducted the Business in material compliance with all applicable laws. Seller holds all
licenses, permits, all material licenses, permits, registrations and other governmental authorizations necessary to conduct the Business. 

2.4 License Agreements. Seller has delivered to Purchaser accurate and complete copies of the License Agreements. Neither Seller nor any
affiliate of Seller has any obligation or Liability with respect to any License Agreement, except as specifically set forth in such License Agreement. With respect to each of the License Agreements: (a) neither Seller nor any affiliate of
Seller has (and, to the Knowledge of Seller, no other Person has) violated or breached, or declared or committed any default under, any such License Agreement; (b) no event has occurred, and no circumstance or condition exists, that might (with
or without notice or lapse of time) result in a violation, breach or default by Seller or any affiliate of Seller (or, to the Knowledge of Seller, by any other Person) of or under any of the provisions of any such License Agreement; (c) neither
Seller nor any affiliate of Seller has received any notice or other communication regarding any actual or alleged violation or breach of, or default under, any such  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 5 of 29 

 
License Agreement; and (d) neither Seller nor any affiliate of Seller has waived any right under any such License Agreement. The License Agreements are valid and in full force and effect.
Seller is not in breach of any of the License Agreements. There are no disputes regarding any of the License Agreements and, to the knowledge of Seller, the relationship between Seller and each of other parties to the License Agreements is in good
standing other than for payments owed to the Licensors which have been identified on Schedule 1.4 hereto. 
 2.5 Authority; Binding Nature
of Agreements. Seller has the requisite corporate power and authority to enter into and to deliver the Transactional Agreements and to perform its obligations under the Transactional Agreements, and the execution, delivery and performance by
Seller of the Transactional Agreements have been duly authorized by all necessary corporate action on the part of Seller. Each of the Transactional Agreements constitutes a legal, valid and binding obligation of Seller, enforceable against it in
accordance with its terms, except to the extent that enforcement thereof may be limited by: (a) bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance or other similar laws now or hereafter in effect relating to
creditors’ rights generally; and (b) general principles of equity (regardless of whether enforceability is considered in a Proceeding at law or in equity). 

2.6 No Conflict; Non-Contravention. The execution and delivery of this Agreement, the performance of Seller’s obligations hereunder
and the consummation of the transactions hereunder (a) do not and will not conflict with or violate any requirement of applicable Law; (b) do not and will not conflict with or violate the certificate of incorporation, by-laws or other
organizational documents of Seller; and (c) do not and will not conflict with, violate, breach or constitute a default under any contractual obligations of Seller or any of its affiliates or any other contract by which the Designated Assets are
bound. The execution and delivery by Seller of the Transactional Agreements, and the sale of the Designated Assets by Seller to Purchaser will not result in the imposition or creation of any lien or Encumbrance upon or with respect to any of the
Designated Assets. Seller is not required to obtain any additional consent from any Person at or prior to the Closing in connection with the execution and delivery of the Transactional Agreements or the sale of the Designated Assets to Purchaser.
Seller is not a party to or otherwise bound by any oral or written legally binding contract or agreement that will result in any other Person obtaining any interest in, or that would give to any other Person any right to assert any claim in or with
respect to, any of such Party’s rights under this Agreement. 
 2.7 No Debarment. None of Seller’s employees,
consultants or contractors: 
 (a) is debarred under Section 306(a) or 306(b) of the FD&C Act or by the analogous Laws
of any Governmental Authority; 
 (b) has, to Seller’s knowledge, been charged with, or convicted of, any felony or
misdemeanor within the ambit of 42 U.S.C. §§ 1320a-7(a), 1320a-7(b)(l)-(3), or pursuant to the analogous Laws of any Governmental Authority, or is proposed for exclusion, or the subject of exclusion or debarment proceedings by Governmental
Authority, during the employee’s or consultant’s employment or contract term with Seller; and 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 6 of 29 

 (c) is excluded, suspended or debarred from participation, or otherwise ineligible to
participate, in any U.S. or non-U.S. health care programs (or has been convicted of a criminal offense that falls within the scope of 42 U.S.C. §1320a-7 but not yet excluded, debarred, suspended, or otherwise declared ineligible), or excluded,
suspended or debarred by a Governmental Authority from participation, or otherwise ineligible to participate, in any procurement or non-procurement programs. 

2.8 Title; Encumbrances. Seller has sufficient legal and beneficial title to or ownership of, and on the Closing Date, Seller will
convey to Purchaser, all of the Designated Assets (tangible and intangible), free and clear from any Encumbrances. 
 2.9 IP Title;
Encumbrances. 
 (a) 

(i) Seller owns all right, title, and interest, including a right to bring actions for infringement or other violations thereof
available by applicable Law in the intellectual property rights included in the Designated Assets (the “Designated IP”) that are not part of the License Agreements, free and clear of any Encumbrances, and no other Person, including any
former or current employee, has any proprietary, commercial, or other interest in the Designated IP; and (ii) there are no existing contracts, options, commitments, or rights with, of, or to any Person to acquire any rights to the Designated
IP; and  
 (ii) has exclusively licensed all right, title, and interest, including a right to bring actions for infringement
or other violations thereof available by applicable Law in the intellectual property rights under the License Agreements included in the Designated Assets, free and clear of any Encumbrances, and no other Person other than the Licensor as provided
in each such License Agreement has any proprietary, commercial, or other interest such the Designated IP; and there are no existing contracts, options, commitments, or rights with, of, or to any Person to acquire any rights to the Designated IP
other than as set forth in each such License Agreement. 
 (b) Seller has not received any written notice from any Third Party
with respect to the Designated Assets (i) asserting or alleging that Seller infringed or misappropriated the intellectual property rights of such Third Party or (ii) challenging or questioning the right of Seller to the Designated IP.
There is no action pending, or threatened before any patent and trademark office (or similar Governmental Authority) that was initiated by any Third Party, or any such threatened action, that may, in either case, render any of the Patents included
in the Designated Assets invalid or unenforceable. 
 (c) The Designated IP is valid and enforceable and is not infringing,
misappropriating or diluting any legally protectable and enforceable intellectual property right of a Third Party, it being understood by the parties that much of the Designated IP consists of pending patent applications for which there can be no
assurance any patents will issue or be enforcible, if issued. No Third Party has asserted that the Designated Assets are invalid or unenforceable. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 7 of 29 

 (d) No Third Party is infringing or misappropriating the Designated IP, including any
current or former employee of or consultant to Seller. 
 2.10 No Proceeding. There are no pending, and to Seller’s
Knowledge, no threatened, adverse actions, claims, investigations, suits or proceedings against any Seller, at Law or in equity, or before or by any Governmental Authority, involving the Designated Assets, or that would have the effect of
restricting Seller’s use of the Designated Assets, or preventing, delaying, making illegal, or otherwise interfering with the Contemplated Transactions, nor to Seller’s Knowledge has any such adverse action, claim, investigation, suit or
proceeding been brought or threatened. 
 2.11 No Non-Competition Agreements. Seller is not bound by any non-competition
agreements related to the Designated Assets, or by any other agreements with Third Parties that limit or restrict use of the Designated Assets or require any payments for their use other than the payment and other obligations in the License
Agreements included in the Designated Assets. 
 2.12 Compliance with Laws. 

(a) Seller has complied in all material respects with all Laws in connection with the prosecution of the Patents included in the
Designated Assets, including the duty of candor owed to any patent office pursuant to such Laws; 
 (b) Seller is in compliance
in all material respects with all Laws with respect to the ownership and use of the Designated Assets; and 
 (c) Seller has
not received any written notices or other communications related to any of the Designated Assets from any Governmental Authority regarding any actual, alleged or threatened material violation of, or failure to comply in all material respects with,
any Law. 
 2.13 No Grant of Rights. Except as set forth in the licenses, Seller has not (a) granted any rights with
respect to the Designated Assets to any Person other than pursuant to this Agreement, or (b) agreed to indemnify any Third Party against any charge of infringement, misappropriation, or dilution of any of the Designated Assets. 

2.14 No Unauthorized Use. No Seller has received any written notice of any unauthorized use, infringement or misappropriation by any
Person, including any current or former employee or consultant of Seller, of any of the Designated Assets. 
 2.15 Renewal and
Maintenance Fees. All material renewal and maintenance fees due with respect to the prosecution and maintenance of the Patents included in the Designated Assets have been paid, it being understood that the licensors have made such payments and
will be reimbursed for certain of those fees as part of the Assumed Liabilities under this Agreement. 
 2.16 Inventors.

  
 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 8 of 29 

 (a) To the Seller’s Knowledge, the inventors named in the Patents in the License
Agreements are all of the true inventors for such Patents and each of such inventors has assigned to the licensor, all of his or her right, title and interest in such Patents and the inventions described therein; and 

(b) To the extent any Patents are assigned by Seller as part of the Designated Assets, the inventors named in such Patentsre all of the
true inventors for such Patents and each of such inventors has assigned to the Seller, all of his or her right, title and interest in such Patents and the inventions described therein. 

2.17 Employee Confidentiality Agreements. All current and former employees and paid consultants (in the case of academic consultants,
those acting outside the scope of their academic affiliation) of Seller who are or have been substantively involved in the conception, design, review, evaluation, reduction to practice, or development of the Designated IP, have executed written
contracts or are otherwise obligated to protect the confidential status and value thereof and to vest in Seller exclusive ownership of the Designated IP, and all intellectual property rights therein. 

2.18 List of Material Contracts. Set forth on Schedule 2.18 is a list as of the Closing Date of all material contracts, including any
material amendments, work orders, or statements of work thereto, relating to the Designated Assets, and all intellectual property rights thereto. 

2.19 Safety and Efficacy. Seller is not aware of any material problems concerning the safety or efficacy of the Designated Assets or of
any questions raised by any Governmental Authority with respect thereto that has not been disclosed to the Purchaser, and Seller has informed Purchaser of all adverse drug reactions known to Seller relating to the Designated Assets or its use.

 2.20 Regulatory Matters. 

(a) Seller has provided or made available any and all material documents and communications in its possession from and to any
Governmental Authority, or prepared by any Governmental Authority, related to the Designated Assets, that may bear on the compliance with the requirements of any Governmental Authority, including any notice of inspection, inspection report, warning
letter, deficiency letter, or similar communication. 
 (b) Seller has not received, with respect to the Designated Assets, any
written communication (including any warning letter, untitled letter, or similar notices) from any Governmental Authority that was not disclosed to Purchaser in writing and, there is no action pending or, to Seller’s Knowledge, threatened
(including any prosecution, injunction, seizure, civil fine, suspension or recall), in each case alleging that with respect to the Designated Assets, Seller is not currently in compliance with any and all applicable Laws implemented by such
Governmental Authority. Seller has not received any written notice from any Governmental Authority claiming that the Designated Assets is not in compliance with all applicable Laws and permits. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 9 of 29 

 (c) Seller has not made, with respect to the Designated Assets, an untrue statement of a
material fact or fraudulent statement to any Governmental Authority or failed to disclose a material fact required to be disclosed to such Governmental Authority. 

2.21 Taxes. (a) Seller has duly and timely filed all Tax returns (taking into account appropriate extensions) required to be filed
with respect to the Designated Assets, each such return is true, correct and complete in all material respects, and Seller has timely paid all Taxes required to be paid with respect to the Designated Assets (whether or not such Taxes are shown as
due on any Tax return); (b) there are no currently proposed or pending or threatened adjustments, audits or examinations by any Governmental Authority in connection with any Taxes relating to the Designated Assets, and there are no matters
under discussion with any Governmental Authority with respect to Taxes that may result in an additional liability for Taxes with respect to which the Designated Assets may be subject, levied, or assessed; (c) there is no waiver or extension of
any statute of limitations with respect to any Tax matter relating to the Designated Assets; (d) no claim has ever been made in writing by a Governmental Authority in a jurisdiction where Seller does not file Tax returns that the Designated
Assets is or may be subject to taxation by that jurisdiction; (e) Seller has not entered into a record retention agreement with any Governmental Authority relating to the Designated Assets that is still in effect; and (f) there are no Tax
Encumbrances with respect to any Designated Assets. 
 2.22 No Undisclosed Liabilities. Seller has no Liabilities with respect
to the Designated Assets, except for current Liabilities incurred in the ordinary course of business consistent with past practices. 

2.23 Books and Records. The material books of account and other records of Seller that relate to the Designated Assets, all of which
have been made available to Purchaser, are complete and correct and represent actual, bona fide transactions. 
 2.24 Compliance
with The Foreign Corrupt Practices Act and Export Control and Antiboycott Laws. Seller and its Representatives have not, to obtain or retain business related to the Designated Assets, directly or indirectly offered, paid or promised to pay, or
authorized the payment of, any money or other thing of value (including any fee, gift, sample, travel expense or entertainment with a value in excess of one hundred dollars ($100.00) in the aggregate to any one individual in any year) or any
commission payment of any amount payable, to: (i) any Person who is an official, officer, agent, employee or representative of any Governmental Authority or of any existing or prospective customer (whether government owned or nongovernment
owned); (ii) any political party or official thereof; (iii) any candidate for political or political party office; or (iv) any other individual or entity while knowing or having reason to believe that all or any portion of such money
or thing of value would be offered, given, or promised, directly or indirectly, to any such official, officer, agent, employee, representative, political party, political party official, candidate, individual, or any entity affiliated with such
customer, political party or official or political office, in each case solely to the extent such act constitute a violation of Law. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 10 of 29 

 2.25 Restriction on Business Activities. There is no court or governmental order to which
Seller is a party to or otherwise binding upon Seller or any of their properties or assets (including the Designated Assets) which has or may reasonably be expected to have the effect of prohibiting or impairing the use of the Designated Assets or
limiting the freedom of Purchaser to engage in any line of business or to compete with any Person. Except as set forth in the licenses, Seller has not entered into any contract under which they are, or Purchaser will be after the Closing, restricted
from selling, licensing, marketing, manufacturing or otherwise distributing or using any of the Designated Assets or from providing services to customers or potential customers or any class of customers, in any geographic area, during any period of
time, or in any segment of the market. 
 2.26 Investment Representations. Seller understands that the Shares have been
registered under the Securities Act. Seller also understands that the Shares are being offered and sold pursuant to an exemption from registration contained in the Securities Act based in part upon Seller’s representations contained in the
Agreement. Seller hereby represents and warrants as follows: 
 (a) Seller has substantial experience in evaluating and
investing in private placement transactions of securities in companies similar to Purchaser so that it is capable of evaluating the merits and risks of its investment in Purchaser and has the capacity to protect its own interests. Seller must bear
the economic risk of this investment indefinitely unless the Shares are registered pursuant to the Securities Act, or an exemption from registration is available. Seller understands that Purchaser has no present intention of registering the Shares,
or any shares of its Common Stock. Seller also understands that there is no assurance that any exemption from registration under the Securities Act will be available and that, even if available, such exemption may not allow Seller to transfer all or
any portion of the Shares under the circumstances, in the amounts or at the times Seller might propose. 
 (b) Seller is
acquiring the Shares for Seller’s own account for investment only, and not with a view towards their distribution. 
 (c)
Seller represents that by reason of its, or of its management’s, business or financial experience, Seller has the capacity to protect its own interests in connection with the transactions contemplated in this Agreement. Further, Seller is
aware of no publication of any advertisement in connection with the transactions contemplated in the Agreement. 
 (d) Seller
represents that it is an accredited investor within the meaning of Regulation D under the Securities Act. 
 (e) Seller has
received and read the financial information of Purchaser and has had an opportunity to discuss Purchaser’s business, management and financial affairs with directors, officers and management of Purchaser and has had the opportunity to review
Purchaser’s operations and facilities. Seller has also had the opportunity to ask questions of and receive answers from, Purchaser and its management regarding the terms and conditions of this investment. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 11 of 29 

 (f) Seller acknowledges and agrees that the Shares are “restricted securities”
as defined in Rule 144 promulgated under the Securities Act as in effect from time to time and must be held indefinitely unless they are subsequently registered under the Securities Act or an exemption from such registration is available. Seller has
been advised or is aware of the provisions of Rule 144, which permits limited resale of shares purchased in a private placement subject to the satisfaction of certain conditions, including, among other things: the availability of certain current
public information about Purchaser, the resale occurring following the required holding period under Rule 144 and the number of shares being sold during any three-month period not exceeding specified limitations. 

(g) The office or offices of Seller in which its investment decision was made is located at the address or addresses of Seller set forth
in Section 6.1. 
 2.27 No Brokers. Seller is not obligated to pay any brokerage, commission, finder’s fee or similar fee
in connection with the transactions contemplated hereby. 
 2.28 Full Disclosure. Seller has disclosed to Purchaser all facts
material to the Designated Assets, or reasonably likely to have material effects on Purchaser’s consideration of the execution of this Agreement and any agreement to be entered into in connection herewith, or consummation of the transactions
contemplated hereby or thereby to one or more officers of the Purchaser. No representation or warranty by Seller in this Agreement or any Schedule hereto contains any untrue statement of a material fact or omits to state any material fact necessary,
in each case with respect to the Designated Assets, to make the statement made herein or therein, in light of the circumstances under which they were made, not misleading. 

SECTION 3. REPRESENTATIONS AND WARRANTIES OF PURCHASER.

 Purchaser represents and warrants to Seller that: 

3.1 Due Organization. Purchaser is a limited liability company duly organized, validly existing and in good standing under the laws of
Delaware. 
 3.2 Authority; Binding Nature of Agreements. Purchaser has the requisite corporate power and authority to enter
into and to deliver each of the Transactional Agreements to which it is a party and to perform its obligations under each such Transactional Agreement, and the execution, delivery and performance by Purchaser of each of the Transactional Agreements
to which it is a party have been duly authorized by all necessary corporate action on the part of Purchaser. Each of the Transactional Agreements constitutes a legal, valid and binding obligation of Purchaser, enforceable against it or them in
accordance with its terms, except to the extent that enforcement thereof may be limited by: (a) bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance or other similar laws now or hereafter in effect relating to
creditors’ rights generally; and (b) general principles of equity (regardless of whether enforceability is considered in a Proceeding at law or in equity). 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 12 of 29 

 3.3 Non-Contravention. The execution and delivery by Purchaser of the Transactional
Agreements, and the purchase of the Designated Assets by Purchaser from Seller will not result in a violation of the charter documents of Purchaser. 

SECTION 4. SURVIVAL AND INDEMNIFICATION. 

4.1 Survival of Representations. 

(a) Subject to Sections 4.1(b) and 4.1(d), the representations and warranties of Seller shall survive the Closing and the sale of the
Designated Assets to Purchaser and shall expire on the date that is [ * ] following the Closing Date (the “Representation Termination Date”); provided, however, that if a Claim Notice (as defined below) relating
to any representation or warranty is given by Seller to Purchaser prior to the Representation Termination Date, then the claim(s) asserted in such Claim Notice shall survive the Representation Termination Date until such time as such claim is (or
claims are) fully and finally resolved. 
 (b) Subject to Section 4.1(d), notwithstanding the foregoing in
Section 4.1(a), the representations and warranties set forth in Sections 2.1, 2.4, 2.5, 2.6 and 2.9 (the “Fundamental Representations”) shall survive the Closing and expire on the applicable statute of limitations,
provided, however, that if a Claim Notice (as defined below) relating to any representation or warranty is given by Seller to Purchaser prior to the applicable expiration date, then the claim(s) asserted in such Claim Notice
shall survive the expiration date until such time as such claim is (or claims are) fully and finally resolved. 
 (c) The
covenants and obligations of each Party shall survive the Closing and the sale of the Designated Assets to Purchaser and shall expire upon the applicable statute of limitation. 

(d) The limitations set forth in this Section 4.1 shall not apply in the case of intentional misrepresentation, intentional
breach or fraud. 
 (e) For purposes of this Agreement, a “Claim Notice” shall be deemed to have been given if
Purchaser delivers to Seller a written notice stating that Purchaser is of the opinion that there is or there may be a breach of a representation or warranty, asserting a claim for recovery under Section 4.2. 

4.2 Indemnification by Seller. From and after the Closing Date (but subject to the limitations set forth in this Section 4),
Seller shall hold harmless and indemnify Purchaser from and against, and shall compensate and reimburse Purchaser for, any Damages that are suffered or incurred by Purchaser or to which Purchaser may otherwise become subject (regardless of whether
or not such Damages relate to any third-party claim) and that arise from or as a result of, or are connected with: 
 (a) Any
inaccuracy in or breach of any of the representations or warranties made by Seller in this Agreement or any certificate or instruments delivered pursuant to this  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
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Agreement (disregarding the materiality qualifiers in the representations and warranties for purposes of determining the amount of damages); 

(b) Any breach of any covenant or obligation of Seller contained in this Agreement; 

(c) Any Liability of Seller; and 

(d) Any fraud or intentional breach or misrepresentation. 

4.3 Limitation on Liability. Notwithstanding anything to the contrary, Seller’s liability to Purchaser: (a) pursuant to
Section 4.2(a) (except with respect to the Fundamental Representations), shall be capped at [ * ] of the Purchase Price then paid to Seller; and (b) with respect to all others matters relating to this Agreement or the transactions
contemplated hereby shall be capped at the amount of the Purchase Price then paid to Seller pursuant to this Agreement. The limitation set forth in this Section 4.3 shall not apply in the case of intentional breach or misrepresentation
or fraud. 
 4.4 Defense of Third-Party Claims. In the event of the assertion or commencement by any Person of any claim or
Proceeding (whether against Purchaser or against any other Person) with respect to which Purchaser may be entitled to indemnification, compensation or reimbursement pursuant to this Section 4.4, Purchaser shall have the right, at its election,
to proceed with the defense of such claim or Proceeding on its own with counsel. Purchaser shall have the right to settle, adjust or compromise such claim or Proceeding; provided, however, that if Purchaser settles, adjusts or
compromises any such claim or Proceeding without the consent of Seller (which consent may not be unreasonably withheld, delayed or conditioned), such settlement, adjustment or compromise shall not be conclusive evidence of the amount of Damages
incurred by Purchaser in connection with such claim or Proceeding but shall, in addition to any out-of-pocket costs and expenses related thereto, serve as a cap thereon. Purchaser shall give Seller prompt notice after it becomes aware of the
commencement of any such claim or Proceeding against Purchaser; provided that any failure on the part of Purchaser to so notify Seller shall not limit Seller’s liability or rights of Seller except to the extent such failure
materially prejudices any aspect of Seller’s defense of such Proceeding. If Purchaser does not elect to proceed with the defense of any such Proceeding, Seller may proceed with the defense of such Proceeding with counsel reasonably satisfactory
to Purchaser; provided, however, that Seller may not settle or compromise any such Proceeding without the prior written consent of Purchaser (which consent may not be unreasonably withheld or delayed). 

4.5 Exclusive Remedy. The Parties hereto agree that the Purchaser’s sole and exclusive remedy after the Closing with
respect to this Agreement, the subject matter thereof and the transactions contemplated hereby, shall be pursuant to the indemnification provisions set forth in this Section 4; provided, however, that the foregoing clause of this
sentence shall not be deemed a waiver of the remedies available to Purchaser as set forth in Sections 5.4(d) and 6.8, nor a waiver by Purchaser of any right to specific performance or injunctive relief, or any right or remedy with
respect to any claim based on intentional breach or misrepresentation or fraud and all claims related thereto shall survive for the applicable statute of limitations. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 14 of 29 

 4.6 Knowledge. Notwithstanding any right of either Party to fully investigate the affairs
of the other Party and notwithstanding any knowledge of facts determined or determinable by such Party pursuant to such investigation or right of investigation, each Party has the right to rely fully upon the representations, warranties, covenants
and agreements of the other Party in this Agreement, any of the other documents referred to herein, the Disclosure Schedule or in any certificate, financial statement, instrument or other document delivered by the other Party pursuant hereto, and
such Party’s right to indemnification under this Article 4 shall not be altered by such investigation or knowledge. 
 SECTION 5.
CERTAIN POST-CLOSING COVENANTS. 
 5.1 Further
Assurances. From and after the Closing, each of Purchaser and Seller will, to the extent reasonably requested by the other Party and at such other Party’s sole expense, execute and deliver such documents and instruments and take such other
actions as such other Party may reasonably request in order to consummate and make effective the transactions contemplated by this Agreement. 

5.2 Publicity. Seller agrees that, on and at all times after the date of this Agreement but only to the extent Purchaser has maintained
confidentiality regarding the transactions contemplated hereby and the terms of this Agreement: (a) no press release or other publicity concerning any of the transactions contemplated hereby shall be issued or otherwise disseminated by it or on
its behalf without Purchaser’s prior written consent; and (b) Seller shall continue to keep the terms of this Agreement strictly confidential. Any disclosure by Seller hereunder following a disclosure by Purchaser shall be limited to and
consistent with the disclosure by Purchaser. 
 5.3 Tax Cooperation. Purchaser and Seller agree to furnish or cause to be
furnished to each other, upon request, as promptly as practicable, such information and assistance relating to the Designated Assets (including access to books and records) as is reasonably necessary for the filing of all tax returns, and making of
any election related to taxes, the preparation for any audit by any taxing authority and the prosecution or defense of any claim, suit or proceeding relating to any tax return. 

5.4 Non-Competition. 

(a) Seller hereby covenants, acknowledges and agrees that it will not, at any time during [ * ] from the Closing Date, either directly
or indirectly, as principal, agent, owner, partner, employee, consultant, shareholder, director or officer, as the case may be, in any manner whatsoever, own, be engaged in, be concerned with, be interested in, operate, have any financial interest
in or advance, lend money to, guarantee the debts or obligations of, permit its name or any part thereof to be used or applied by any Person, firm or corporation engaged in or concerned with or interested in, directly or indirectly, in any
Competitive Activity in any territory in which the Products are currently planned to be commercialized, except as a passive shareholder holding less than [ * ] percent of the outstanding shares of a corporation offering its shares to the public and
whose shares are listed and posted for trading on a recognized stock exchange. 
  
 [
* ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS,
IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 15 of 29 

 (b) Relief. 

(i) Injunctive Relief. Seller acknowledges that breach of Seller’s covenants contained in this Section 5.4 may cause
irreparable harm to the Business, which may not be compensable through monetary damages. Seller therefore hereby acknowledges that in the event of a breach or a threatened breach by Seller or its affiliates of such covenants, Purchaser will be
entitled, in addition to any other rights, remedies or damages which may be available to Purchaser, at law or in equity, to obtain an interim and permanent injunction in order to prevent or restrain any breach or threatened breach of this Agreement
by Seller or its affiliates, partners, employers, employees, servants, agents, representatives, and other Persons directly or indirectly acting for, or on behalf of, or with, Seller. Seller further agrees that Purchaser shall be entitled to
injunctive relief without having to prove damages. 
 (ii) Restrictions Reasonable. Purchaser and Seller acknowledge and confirm
that: 
 (1) they have been independently advised by their respective counsel with respect to the provisions of this
Section 5.4; 
 (2) they have negotiated the provisions of Section 5.4 on an equal footing based on equal
bargaining power at the Closing Date; 
 (3) neither Purchaser nor Seller were required or induced by force, threats, or other means
of intimidation or in any other manner to enter into this Agreement; 
 (4) the provisions of this Section 5 are
reasonable and do not go beyond what is necessary to protect the interests of Purchaser; and 
 (5) this Agreement is supported by
adequate consideration. 
 5.5 Confidentiality. Seller covenants and agrees not to at any time, directly or indirectly, use, disclose
or publish, or permit other Persons (including affiliates of Seller), to directly or indirectly use, disclose or publish, any Confidential Information, except as set forth herein or unless (a) such information becomes generally known to the
public through no fault of Seller, (b) Seller is advised by counsel that disclosure is required by law or the order of any Governmental Authority of competent jurisdiction under color of law, or (c) Seller reasonably believes (based on
advice of counsel) that such disclosure is required in connection with the defense of a lawsuit; provided, that prior to disclosing any information pursuant to clause (b) or (c) above, Seller shall give prior written notice thereof to
Purchaser and provide Purchaser with the opportunity to contest or limit such disclosure and shall cooperate with efforts to prevent such disclosure. 

SECTION 6. MISCELLANEOUS PROVISIONS. 

6.1 Notices. All notices, requests, demands and other communications under this Agreement shall be in writing and shall be deemed to
have been duly given or made as follows:  
  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
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(a) if sent by registered or certified mail in the United States return receipt requested, upon receipt; (b) if sent designated for overnight delivery by nationally recognized overnight air
courier (such as Federal Express), upon receipt; (c) if sent by facsimile transmission before 5:00 p.m. in California, when transmitted and receipt is confirmed; (d) if sent by facsimile transmission after 5:00 p.m. in California and
receipt is confirmed, on the following business day; and (e) if otherwise actually personally delivered, when delivered, provided that such notices, requests, demands and other communications are delivered to the address set forth below, or to
such other address as either Party shall provide by like notice to the other Party: 
 If to Seller: 

Eiccose, LLC 
 1115 Lafayette
Street 
 Santa Clara, CA 95050 

Attention: Manager 
 Facsimile:
                     
 If to
Purchaser: 
 Eiger BioPharmaceuticals, Inc. 

350 Cambridge Avenue, Suite 350 

Palo Alto, CA 94306 
 Attention:
David Cory 
 Facsimile:
                     
 With copies (which shall
not constitute notice) to: 
 Cooley LLP 

3175 Hanover St. 
 Palo Alto, CA
94304 
 Attention: Glen Sato 

Facsimile: (650) 849-7400 

6.2 Headings. The bold-faced headings contained in this Agreement are for convenience of reference only, shall not be deemed to be a
part of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. 
 6.3
Counterparts and Exchanges by Electronic Transmission or Facsimile. This Agreement may be executed in counterparts, each of which shall constitute an original and both of which, when taken together, shall constitute one agreement. The exchange
of a fully executed Agreement (in counterparts or otherwise) by electronic transmission or facsimile shall be sufficient to bind the Parties to the terms and conditions of this Agreement. 

6.4 Governing Law; Venue. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 17 of 29 

 (a) This Agreement shall be construed in accordance with, and governed in all respects by,
the internal laws of the State of Delaware (without giving effect to principles of conflicts of laws). 
 (b) Any proceeding
relating to this Agreement or the enforcement of any provision of this Agreement shall be brought or otherwise commenced in any state or federal court located in the State of California. Each Party: 

(i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in the State of
California (and each appellate court located in the State of California) in connection with any such proceeding; 
 (ii)
agrees that each state and federal court located in the State of California shall be deemed to be a convenient forum; and  

(iii) agrees not to assert (by way of motion, as a defense or otherwise), in any such proceeding commenced in any state or federal
court located in the State of California, any claim that such Party is not subject personally to the jurisdiction of such court, that such proceeding has been brought in an inconvenient forum, that the venue of such proceeding is improper or that
this Agreement or the subject matter of this Agreement may not be enforced in or by such court. 
 6.5 WAIVER OF TRIAL BY JURY.
EACH PARTY WAIVES THE RIGHT TO A JURY TRIAL IN CONNECTION WITH ANY LAWSUIT, ACTION OR PROCEEDING SEEKING ENFORCEMENT OF SUCH PARTY’S RIGHTS UNDER THIS AGREEMENT. 

6.6 Successors and Assigns; Parties in Interest. Except as otherwise expressly provided herein, the provisions hereof shall inure to the
benefit of, and be binding upon the parties hereto and their respective successors, assigns, heirs, executors and administrators. Seller may not assign any of its rights or delegate any of its obligations under this Agreement to any other Person
without the prior written consent of Purchaser. Purchaser may freely assign any or all of its rights hereunder, in whole or in part, to any other Person without obtaining the consent or approval of any other Person. 

6.7 Waiver. No failure on the part of either Party to exercise any power, right, privilege or remedy under this Agreement, and no delay
on the part of either Party in exercising any power, right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power, right, privilege or
remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. 
 6.8 Specific
Performance. Each Party agrees that: (a) in the event of any breach or threatened breach by the other Party of any covenant, obligation or other provision set forth in this Agreement, such Party shall be entitled (in addition to any other
remedy that may be available to it) to: (i) a decree or order of specific performance or mandamus to enforce the observance and performance of such covenant, obligation or other provision; and (ii) an  

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
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injunction restraining such breach or threatened breach; and (b) neither Party shall be required to provide any bond or other security in connection with any such decree, order or injunction
or in connection with any related legal proceeding. 
 6.9 Amendments. This Agreement may not be amended, modified, altered or
supplemented other than by means of a written instrument duly executed and delivered on behalf of Seller and Purchaser. 
 6.10
Severability. In the event that any provision of this Agreement, or the application of any such provision to either Party or set of circumstances, shall be determined to be invalid, unlawful, void or unenforceable to any extent, the remainder of
this Agreement, and the application of such provision to a Party or circumstances other than those as to which it is determined to be invalid, unlawful, void or unenforceable, shall not be impaired or otherwise affected and shall continue to be
valid and enforceable to the fullest extent permitted by law. 
 6.11 Expenses. Each Party shall bear and pay all fees, costs
and expenses that have been incurred or that are in the future incurred by, on behalf of or for the benefit of, such Party in connection with the negotiation, preparation and review of this Agreement and the other Transactional Agreements and the
consummation and performance of the transactions contemplated herein. 
 6.12 Entire Agreement. The Transactional Agreements
set forth the entire understanding of the Parties relating to the subject matter thereof and supersede all prior agreements and understandings between the Parties relating to the subject matter thereof. 

6.13 Waiver of Conflicts. Each Party to this Agreement acknowledges that Cooley LLP (“Cooley”), outside general counsel
to Purchaser, has in the past performed and may in the future represent Seller or its affiliates in matters unrelated to the transactions contemplated by this Agreement and that a waiver by each Party has been provided in connection with this
transaction (the “Acquisition”). The applicable rules of professional conduct require that Cooley inform the parties hereunder of this representation and obtain their consent. Cooley has served as outside general counsel to
Purchaser and has negotiated the terms of the Acquisition solely on behalf of Purchaser. Seller and Purchaser hereby (a) acknowledge that they have had an opportunity to ask for and have obtained information relevant to such representation,
including disclosure of the reasonably foreseeable adverse consequences of such representation; (b) acknowledge that with respect to the Acquisition, Cooley has represented solely Purchaser, and not Seller or any stockholder, director or
employee of Seller or Purchaser; and (c) gives its informed consent to Cooley’s representation of Purchaser in the Acquisition. 

6.14 Construction. 

(a) For purposes of this Agreement, whenever the context requires: the singular number shall include the plural, and vice versa; the
masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include the masculine and feminine genders. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 19 of 29 

 (b) The Parties agree that any rule of construction to the effect that ambiguities are to
be resolved against the drafting Party shall not be applied in the construction or interpretation of this Agreement. 
 (c) As
used in this Agreement and Exhibit A, the words “include” and “including,” and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without
limitation.” 
 (d) Except as otherwise indicated, all references in this Agreement to “Sections,” “Exhibits”
and “Schedules” are intended to refer to Sections of this Agreement and Exhibits and Schedules to this Agreement. 

[Remainder of page intentionally left blank] 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 20 of 29 

 The Parties have caused this Agreement to be executed and delivered as of the date first above
mentioned. 
  

			
	PURCHASER:
	
	Eiger BioPharmaceuticals, Inc.
		
	By:	 	 /s/ James Welch

	Name:	 	James Welch
	Title:	 	CFO
	
	SELLER:
	
	EICCOSE, LLC
		
	By:	 	 /s/ David Cory

	Name:	 	David Cory
	Title:	 	CEO

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 21 of 29 

 LIST OF EXHIBITS 

Exhibit A - Certain Definitions 
 LIST
OF SCHEDULES 
 Disclosure Schedule 

Schedule 1.2 – Reimbursed Expenses 
 Schedule 1.4 –
Assumed Liabilities 
 Schedule 1.6 – Purchase Price Allocation 

Schedule 2.17 – Material Contracts 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 22 of 29 

 EXHIBIT A 

CERTAIN DEFINITIONS 

For purposes of the Agreement (including this Exhibit A): 

Agreement. “Agreement” shall mean the Asset Purchase Agreement (including the Disclosure Schedule), to which this Exhibit
A is attached as it may be amended from time to time. 
 Business. “Business” shall mean all activity related to
Seller’s development, ownership and use of the Designated Assets. 
 Competitive Activity. “Competitive
Activity” shall mean the research or development of, sale, testing, marketing, commercialization or offer of the Product or any product or service that competes with the Product or that could be developed and commercialized for the same
indications as the Product. 
 Confidential Information. “Confidential Information” shall mean all non-public
information regarding the Designated Assets. 
 Contemplated Transactions. “Contemplated Transactions” shall mean
all of the transactions contemplated by this Agreement. 
 Damages. “Damages” shall mean any loss, damage, injury,
liability, tax, fee (including any reasonable legal fee), charge or similar expense, excluding any punitive, unforeseeable consequential damages or exemplary damages. 

Disclosure Schedule. “Disclosure Schedule” shall mean the disclosure schedule delivered by Seller to Purchaser
contemporaneously with the execution and delivery of the Agreement. 
 Encumbrance. “Encumbrance” shall mean any
lien, pledge, hypothecation, charge, mortgage, security interest, encumbrance, equity, trust, equitable interest, claim, preference, right of possession, lease, tenancy, license, encroachment, covenant, infringement, interference, Order, proxy,
option, right of first refusal, preemptive right, community property interest, legend, defect, impediment, exception, reservation, limitation, impairment, imperfection of title, condition or restriction of any nature (including any restriction on
the transfer of any asset, any restriction on the receipt of any income derived from any asset, any restriction on the use of any asset and any restriction on the possession, exercise or transfer of any other attribute of ownership of any asset).

 First Commercial Sale. “First Commercial Sale” means the date after regulatory approval in any indication on which
Product is first sold to an independent third party, which  
  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 23 of 29 

 
sale is not an “at risk” sale into the market (i.e., sold before resolving outstanding patent laws suits involving a generic product). First Commercial Sale shall not include Products
used for samples or for research, test marketing, clinical trial purposes, compassionate or other similar use or for warehousing or staging in advance of release of the Licensed Product for commercial sale. 

Governmental Authority. “Governmental Authority” means any federal, national, state, provincial or local government, or
political subdivision thereof (including any agency, branch, office, commission, or council), or any multinational organization or any authority, agency, or commission entitled to exercise any administrative, executive, judicial, legislative,
police, regulatory or taxing authority or power, any court or tribunal (or any department, bureau or division thereof, or any governmental arbitrator or arbitral body). 

Knowledge. “Knowledge” means the actual or constructive knowledge of any director or officer of Seller, after reasonable
inquiry under the circumstances. 
 Law. “Law” means any federal, state, local, foreign or multinational law,
statute, standard, ordinance, code, rule, regulation, resolution or promulgation, or any order by any Government Authority, or any license, franchise, permit or similar right granted under any of the foregoing, or any similar provision having the
force or effect of law. 
 Liability. “Liability” shall mean any debt, obligation, duty or liability of any nature
(including any unknown, undisclosed, unmatured, unaccrued, unasserted, contingent, indirect, conditional, implied, vicarious, derivative, joint, several or secondary liability), regardless of whether such debt, obligation, duty or liability would be
required to be disclosed on a balance sheet prepared in accordance with generally accepted accounting principles and regardless of whether such debt, obligation, duty or liability is immediately due and payable. 

Net Sales. “Net Sales” means, with respect to the Product, the total amount invoiced by Purchaser or its licensees to each
third party receiving the Product in arm’s length transactions, less the following deductions from such total amounts which are actually incurred, allowed, accrued or specifically allocated: (a) normal and customary trade, cash and
quantity discounts, and inventory write-offs (including amounts repaid, discounted or credited by reason of risk sharing schemes with any Governmental Authority or any Pricing Authority), actually given, credits, price adjustments or allowances for
damaged, outdated or defective Product, delayed ship orders, returns, or rejections of Product, including recalls and allowances for uncollectible amounts and/or bad debts on previously sold Products; (b) chargeback payments and rebates (or the
equivalent thereof) (including amounts repaid, discounted or credited by reason of retroactive price reductions, discounts, or rebates, which are, in each case, imposed upon Purchaser or licensees by any Governmental Authority or any Pricing
Authority), and other payments required by law to be made under Medicaid, Medicare and other government special medical assistance programs, branded prescription drug fees (or similar fees or Taxes) due under the Affordable Care Act (or similar
legislation), for the Product granted to group purchasing organizations, managed health care organizations or to federal, state/provincial, local and other governments, including their agencies, purchasers, reimbursers, Pricing Authorities, or to
trade customers; (c) reasonable and customary freight, shipping insurance and other transportation expenses related to  
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 24 of 29 

 
the sale of the Product; (d) required distribution commissions/fees payable to any third party providing distribution services to Purchaser or licensees; (e) other customary commercial
price adjustments, including shelf stock adjustments and reprocurement charges; and (f) sales, value-added, excise taxes, tariffs and duties, and other Taxes and government charges directly related to the sale, to the extent that such items are
included in the gross invoice price of the Product and borne by Purchaser or licensees. For the purposes of this definition: (x) the transfer of the Product by Purchaser or one of its affiliates or licensees to another affiliate shall not be
considered a sale; and (y) any disposal of the Product for, or use of the Product in or for sample authorization, research, test marketing, clinical trial purposes, compassionate or other similar use (at or below cost) or for warehousing or
staging in advance of release of the Product for commercial sale, shall not give rise to any deemed sale under this definition. 

Patent(s). “Patent(s)” shall mean any issued patent or pending patent application (including
inventor’s certificates and utility models) or patent rights to inventions, in any country or jurisdiction, including all provisionals, substitutions, continuations, continuations-in-part, divisionals, supplementary protection certificates,
renewals, all letters patent granted thereon, and all reissues, reexaminations, extensions, confirmations, revalidations, registrations, patents of addition thereof, PCTs, pediatric exclusivity periods, and foreign equivalents to any of the
foregoing. 
 Person. “Person” shall mean any individual, corporation, partnership, limited liability company, or
other legal entity or governmental body other than Purchaser and Seller. 
 Pricing Authority. “Pricing Authority”
means any public body (including the National Institute of Clinical Excellence and the Scottish Medicines Consortium in the U.K.; the Institute for Quality and Efficiency in Healthcare in Germany; the Technical Scientific Commission in Italy; the
Directorate of Pharmacy and Healthcare Products in Spain; and the National Union of Health Insurance Funds and the National Authority of Health in France) or non-Governmental Authority (including “Sick Funds” in
Germany) with the authority to control, approve, recommend or otherwise determine pricing and reimbursement of pharmaceutical products, including those with authority to enter into risk sharing schemes and/or to impose retroactive price reductions,
discounts, or rebates. 
 Proceeding. “Proceeding” shall mean any action, suit, litigation, arbitration, proceeding
(including any civil, criminal, administrative, investigative or appellate proceeding and any informal proceeding), prosecution, contest, hearing, inquiry, inquest, audit, examination or investigation commenced, brought, conducted or heard by or
before, or otherwise involving, any governmental body or any arbitrator or arbitration panel. 
 Product. “Product”
shall mean any pharmaceutical product that contains or uses (a) the Seller’s compound known as Bestatin (ubenimex) or (b) Seller’s compound identified as an LTB4 inhibitor, in either case, in any formulation or dosage form as a
method of treatment. 
 Securities Act. “Securities Act” shall mean Securities Act of 1933, as amended. 

 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES
EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 25 of 29 

 Tax. “Tax” shall mean any tax (including any income tax, franchise tax, capital
gains tax, estimated tax, gross receipts tax, value-added tax, surtax, excise tax, ad valorem tax, transfer tax, stamp tax, sales tax, use tax, property tax, business tax, occupation tax, inventory tax, occupancy tax, withholding tax or payroll
tax), levy, assessment, tariff, impost, imposition, toll, duty (including any customs duty), deficiency or fee, and any related charge or amount (including any fine, penalty or interest), that is, has been or may in the future be (a) imposed,
assessed or collected by or under the authority of any governmental body, or (b) payable pursuant to any tax-sharing agreement or similar contract. 

Third Party. “Third Party” means any Person other than a Party or an affiliate of a Party. 

Transactional Agreements. “Transactional Agreements” shall mean the Agreement any other documents delivered by Seller to
Purchaser to complete the transactions contemplated hereby. 
 Valid Claim. “Valid Claim” means (i) a claim of
any issued and unexpired Patent whose validity, enforceability, or patentability has not been affected by any of the following: (A) irretrievable lapse, abandonment, revocation, dedication to the public, or disclaimer; or (B) a holding,
finding, or decision of invalidity, unenforceability, or non-patentability by a court, governmental agency, national or regional patent office, or other appropriate body that has competent jurisdiction, such holding, finding, or decision being final
and unappealable or unappealed within the time allowed for appeal; or (ii) a claim of a pending Patent application that was filed and is being prosecuted in good faith, has not been outstanding for more than [ * ] and has not been abandoned or
finally disallowed without the possibility of appeal or re-filing of the application. 
  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 26 of 29 

 SCHEDULE 1.2 

REIMBURSED EXPENSES 

Eiccose Expenses Paid Out (to be reimbursed) 
  

					
	 Expense
	  	Amount ($)	 
	 [*]
	  	 	[	*] 
	 [*]
	  	 	[	*] 
	 [*]
	  	 	[	*] 
	 [*]
	  	 	[	*] 
	 [*]
	  	 	[	*] 
		  	  
	  
	 
	 Total
	  	 	[	*] 

 Eiccose Payables (accrued and to be paid) 

 

					
	 Expense
	  	 Amount ($)
	 
	 [*]
	  	 	[	*] 
		  	  
	  
	 
	 Total
	  	 	[	*] 

  
 [ * ] = CERTAIN
CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 27 of 29 

 SCHEDULE 1.4 

ASSUMED LIABILITIES 
  

	1.	License Agreements. 

  

	2.	See Schedule 1.2. 

  
 [ * ] =
CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2
OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

  
 Page 28 of 29 

 SCHEDULE 2.17 

MATERIAL CONTRACTS 
  

	1.	PharmaDirections, Inc. – WK0-EIG-954, Assistance in Ubenimex Dosage Form Manufacturing dated August 10, 2015 

  

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS
DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. 

  
 Page 29 of 29

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