Document:

EXHIBIT 4.01

 

Eighth Amendment
To Loan And Security Agreement

This EIGHTH AMENDMENT TO LOAN AND SECURITY
AGREEMENT (this “Amendment”), dated as of May 30, 2018, is among AMYRIS, INC., a Delaware corporation (the “Parent”),
and each of its Subsidiaries that has delivered a Joinder Agreement (as defined herein) (each a “Subsidiary Guarantor”
and collectively, the “Subsidiary Guarantors” and together with Parent, collectively, “Borrower”),
the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred
to as “Lender”) and STEGODON CORPORATION, a Delaware corporation, as successor-in-interest to Hercules Technology
Growth Capital, Inc., a Maryland corporation, in its capacity as administrative agent for itself and the Lender (in such capacity,
the “Agent”).

Recitals

A.             
WHEREAS, Parent, Subsidiary Guarantors, Lender and Agent have previously entered into that certain Loan and Security Agreement,
dated as of March 29, 2014, as previously amended on June 12, 2014, March 31, 2015, October 12, 2015, November 30, 2015, May 9,
2016, June 24, 2016, June 29, 2016, July 18, 2016, October 5, 2016, October 6, 2016, October 27, 2016, November 29, 2016, December
5, 2016, December 14, 2016, December 17, 2016, December 30, 2016, January 10, 2017, April 13, 2017, November 13, 2017, December
28, 2017, and March 30, 2018 (as further amended from time to time, the “Loan Agreement”), pursuant to which,
among other things, Lender has provided certain term loans and other financial accommodations to Borrower;

B.             
WHEREAS, Borrower desires to amend the Loan Agreement by extending the date for a principal payment in the amount of $5,500,000
due under the terms of the Loan Agreement from May 31, 2018 to July 2, 2018; and

C.             
WHEREAS, Agent and the Lenders are willing to so amend the Loan Agreement as more specifically set forth herein, subject
to the terms and conditions contained herein.

Now,
Therefore, for good and valuable consideration (the receipt and sufficiency of which are hereby acknowledged), in reliance
upon the representations and warranties made in support thereof and contained herein, the parties hereto agree as follows:

1.              
Defined Terms. Each capitalized term used but not otherwise defined herein has the meaning ascribed thereto in the Loan
Agreement.

2.              
Amendments to Loan and Security Agreement. Subject to the satisfaction of the conditions precedent set forth in Section
3 of this Amendment and effective as of the Eighth Amendment Effective Date (notwithstanding the date of execution of this Amendment),
the Loan Agreement is hereby amended as follows:

(a)            
Section 1.1 (Definitions). The Loan Agreement is hereby amended by inserting the following definition to appear alphabetically
in Section 1.1 thereof:

“      “July 2018 Principal
Payment” is defined in Section 2.2(d)(ii)(y).”

     

     

    

(b)           
Section 2.2(d) (Payments). The Loan Agreement is hereby amended by amending Section 2.2(d)(ii)(y) in its entirety and replacing
it with the following:

“     (y) on or prior to July 2,
2018, a principal payment of $5,500,000 (the “July 2018 Principal Payment”), which payment shall be applied
to the principal amount of Secured Obligations then outstanding. The date on which such payment is received by Agent shall be the
“2018 Principal Payment Date”.”

3.              
Conditions to Effectiveness. The provisions of this Amendment shall become effective on the date, which date (if ever)
shall be on or prior to May 31, 2018, that all of the following conditions precedent have been satisfied (the “Eighth
Amendment Effective Date”):

(a)            
Agent shall have received a pdf copy of this Amendment, duly executed and delivered by Parent and the Subsidiary Guarantor;

(b)           
Each of the representations and warranties of Borrower in Section 4 of this Amendment shall be true, correct and accurate
in all material respects as of the Eighth Amendment Effective Date;

(c)            
No Material Adverse Effect has occurred;

(d)           
Agent shall have received either (i) a secretary’s certificate certifying as to the Borrower’s charter documents,
authorizations and incumbency matters in form and substance satisfactory to Agent, or (ii) a confirmation satisfactory to Agent
in its sole discretion that the Borrower’s charter documents, authorizations and incumbency have not changed since previously
delivered to Agent;

(e)            
No Event of Default exists under the Loan Agreement or any Loan Document;

(f)            
Borrower shall have paid to Agent’s counsel all legal fees and out-of-pocket expenses incurred in connection with
the Loan Documents and this Amendment; and

(g)           
All legal matters incident to the execution and delivery of this Amendment shall be satisfactory to Agent and its counsel.

4.              
Representations, Warranties and Agreements. Borrower hereby represents, warrants and agrees in favor of Agent and Lender
as follows:

(a)            
No Event of Default has occurred and is continuing (or would result from the amendment of the Loan Agreement contemplated
hereby);

(b)           
The execution, delivery and performance by Borrower of this Amendment have been duly authorized by all necessary corporate
and/or other action and do not and will not require any registration with, consent or approval of, notice to or action by, any
Person in order to be effective and enforceable. Each of the Loan Agreement and the other Loan Documents to which Borrower is a
party constitutes and continues to constitute the legally, valid and binding obligation of Borrower, in each case enforceable against
Borrower in accordance with its terms;

    	 	- 2 -	 

     

    

(c)            
All of the representations and warranties of Borrower contained in the Loan Agreement and the other Loan Documents are true
and correct in all material respects on and as of the date hereof and will be true and correct on the Eighth Amendment Effective
Date (except to the extent that such representations and warranties specifically refer to an earlier date, in which case they shall
be true and correct in all material respects as of such earlier date, and in each case, without duplication of any materiality
qualifiers);

(d)           
No Material Adverse Effect has occurred;

(e)            
Borrower is entering into this Amendment on the basis of such Person’s own business judgment, without reliance upon
Agent or Lender; and

(f)            
Borrower acknowledges and agrees that the execution and delivery by Agent and Lender of this Amendment shall not be deemed
to create a course of dealing or otherwise obligate Agent or Lender to execute similar agreements under the same or similar circumstances
in the future. Neither Agent nor Lender has any obligation to Borrower or any other Person to further amend provisions of the Loan
Agreement or the other Loan Documents. Other than as specifically contemplated hereby, all of the terms, covenants and provisions
of the Loan Agreement (and the other Loan Documents) are and shall remain in full force and effect.

5.              
Amendment Fee. As consideration for this Amendment, Borrower shall pay to Agent an amendment fee equal to $100,000.00
(the “Amendment Fee”), for the ratable benefit of the Lenders, which fee shall be fully earned on the Eighth
Amendment Effective Date and due and payable on July 2, 2018. The Amendment Fee shall not be refunded or repaid to Borrower under
any circumstances; provided, that the Amendment Fee shall be forgiven by the Agent and the Lenders if Borrower shall have indefeasibly
paid the July 2018 Principal Payment in full in cash on or prior to July 2, 2018.

6.              
General Provisions.

(a)            
Upon the effectiveness of this Amendment, all references in the Loan Agreement and in the other Loan Documents to the Loan
Agreement shall refer to the Loan Agreement as modified hereby. This Amendment shall be deemed incorporated into, and a part of,
the Loan Agreement. This Amendment is a Loan Document. THIS AMENDMENT IS EXPRESSLY SUBJECT TO THE PROVISIONS OF SECTION 11.8
(GOVERNING LAW), SECTION 11.9 (CONSENT TO JURISDICTION AND VENUE) AND SECTION 11.10 (MUTUAL WAIVER OF JURY TRIAL;
JUDICIAL REFERENCE) OF THE LOAN AGREEMENT, WHICH PROVISIONS ARE INCORPORATED HEREIN AND MADE APPLICABLE HERETO BY THIS REFERENCE.

(b)           
This Amendment is made pursuant to Section 11.3(b) and 11.7 of the Loan Agreement and shall be binding upon
and inure to the benefit of the parties hereto and thereto and their respective successors and assigns. No third party beneficiaries
are intended in connection with this Amendment.

(c)            
This Amendment may be executed in counterparts (and by different parties hereto in different counterparts), each of which
shall constitute an original, but all of which when taken together shall constitute a single contract. Delivery of an executed
counterpart of a signature page of this Amendment by telecopy or other electronic means shall be effective as delivery of a manually
executed counterpart of this Amendment.

    	 	- 3 -	 

     

    

(d)           
Each provision of this Amendment shall be severable from every other provision of this Amendment for the purpose of determining
the legal enforceability of any specific provision.

(e)            
Borrower shall promptly pay to Agent’s counsel all attorneys’ fees and expenses incurred in connection with
the preparation, negotiation and closing of this Amendment.

(f)            
The appearing parties herein declare that all the terms and conditions of the Loan Agreement continue to remain, as herein
amended, in full force and effect and by these presents the appearing parties hereby ratify, reaffirm and confirm all the terms
and conditions of the Loan Agreement and further declare that it is their express intention that the transactions set forth in
this Amendment shall in no way, manner or form be construed or be interpreted as an extinctive novation of any of the obligations
and agreements set forth in the Loan Agreement.

[Document continues with signature pages.]

 

 

 

    	 	- 4 -	 

     

    

IN WITNESS WHEREOF, the parties hereto have
caused this Eighth Amendment to Loan and Security Agreement to be duly executed and delivered
as of the date first written above.

 

		AMYRIS, INC.
	 	 
	 	By:  /s/ Kathleen Valiasek
	 	Print Name: Kathleen Valiasek
	 	Title: Chief Financial Officer
	 	 
	 	 
	 	 
	 	 
	 	AMYRIS FUELS, LLC
	 	 
	 	By:  /s/ Kathleen Valiasek
	 	Print Name: Kathleen Valiasek
	 	Title: Chief Financial Officer
	 	 
	 	 
	 	AGENT:
	 	 
	 	STEGODON CORPORATION
	 	 
	 	 
	 	Signature: /s/ Austin Che
	 	Print Name: Austin Che
	 	Title: President
	 	 
	 	 
	 	LENDER:
	 	 
	 	STEGODON CORPORATION
	 	 
	 	 
	 	Signature: /s/ Austin Che
	 	Print Name: Austin Che
	 	Title: PresidentEXHIBIT 4.02

 

FOURTH AMENDMENT TO 12% SENIOR CONVERTIBLE NOTE (RS-10)

This Fourth Amendment to 12% Senior Convertible
Note (RS-10) (this “Amendment”) is made and entered into as of May 31st, 2018, by and between Amyris, Inc.,
a Delaware corporation (the “Company”), and Total Raffinage Chimie S.A., as assignee of Total Energies Nouvelles
Activités USA (the “Investor”).

 

RECITALS

 

WHEREAS, on March 21, 2016 the Company issued
to the Investor a Senior Convertible Note (RS-10) in the principal amount of $3,700,000, as amended by (i) that First Amendment
to 1.5% Senior Convertible Note (RS-10) dated February 27, 2017, (ii) that Second Amendment to 1.5% Senior Convertible Note (RS-10)
dated May 12, 2017 and (iii) that Third Amendment to 1.5% Senior Convertible Note (RS-10) dated March 30, 2018 (as amended, the
“Note”).

 

WHEREAS, the Company and the Investor desire
to further amend the Note as set forth herein.

 

WHEREAS, pursuant to Section 7 of the Note,
the Note may be amended with the written consent of the Company and the Investor.

 

NOW, THEREFORE, for good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows:

 

		1.	Amendment of Section 2(a) of the Note. Section 2(a) of the Note is hereby deleted
in its entirety and replaced with the following:

(a)                  Interest.
This Note shall bear interest (i) from the Issue Date to May 15, 2017 on the Face Amount at a rate per annum equal to 1.50% (subject
to Section 4(k)) and (ii) from May 16, 2017 to the Final Maturity Date on the Face Amount at a rate per annum equal to 12.00%
(subject to Section 4(k)). Interest on this Note shall accrue daily and be due and payable in arrears on (i) December 31, 2017,
(ii) March 31, 2018, (iii) May 31, 2018 and (iv) the Final Maturity Date, and at such other times as may be specified herein.
All computations of interest shall be made on the basis of a 360-day year and actual days elapsed (which results in more interest
being paid than if computed on the basis of a 365-day year). Notwithstanding the foregoing, if an Event of Default shall have
occurred and be continuing this Note shall bear interest on the Face Amount at a rate per annum equal to 13.50% (as may be further
adjusted pursuant to Section 4(k)).

		2.	Amendment of Section 2(b) of the Note. Section 2(b) of the Note is hereby deleted
in its entirety and replaced with the following:

    	 	1	 

     

    

(b)                  Scheduled
Payment of Principal. Unless paid, converted or cancelled and extinguished earlier in accordance with the terms hereof, the
Company shall deliver to the Investor cash in the amount of the Face Amount, together with all accrued and unpaid interest on this
Note, on July 2, 2018 (the “Final Maturity Date”) and this Note shall be retired and canceled.

		3.	Full Force and Effect. Except as expressly modified by this Amendment, the terms
of the Note shall remain in full force and effect.

		4.	Integration. This Amendment and the Note constitute the entire agreement and understanding
of the parties with respect to the subject matter hereof, and supersede all prior understandings and agreements, whether oral or
written, between or among the parties hereto with respect to the specific subject matter hereof.

		5.	Counterparts; Facsimile. This Amendment may be executed in one (1) or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. This Amendment
may be executed and delivered by facsimile, or by email in portable document format (.pdf), and delivery of any signature page
by such method will be deemed to have the same effect as if the original signature had been delivered to the other party.

 

[Remainder of Page intentionally
left blank]

 

 

 

 

    	 	2	 

     

    

IN WITNESS WHEREOF, the parties hereto have executed
this Amendment as of the date first above written.

 

AMYRIS, INC.

By: /s/ Kathleen Valiasek

Name: Kathleen Valiasek

Title: Chief Financial Officer

 

 

 

 

 

 

 

[Signature Page to Fourth Amendment to R&D Note]

 

    	 		 

     

    

IN WITNESS WHEREOF, the parties hereto have executed
this Amendment as of the date first above written.

 

Total Raffinage Chimie S.A.

By: /s/ Nathalie Brunelle

Name: Nathalie Brunelle

Title: Deputy CEO

 

 

 

 

 

 

 

 

[Signature Page to Fourth Amendment to R&D Note]

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