Document:

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                                                                   Exhibit 10.20

                              FIRST LEASE AMENDMENT

         THIS FIRST LEASE AMENDMENT (the "Amendment") is executed this _____ day
of _________________, 2004, by and between DUKE REALTY LIMITED PARTNERSHIP, an
Indiana limited partnership, formerly known as Duke-Weeks Realty Limited
Partnership ("Landlord"), and CATHETER AND DISPOSABLE TECHNOLOGY, INC., a
Minnesota corporation, formerly known as CMED Catheter & Disposables Technology,
Inc. ("Tenant").

                              W I T N E S S E T H :
                              - - - - - - - - - -

         WHEREAS, Landlord and Tenant entered into a certain lease dated May 31,
2001 (the "Lease"), whereby Tenant leased from Landlord certain premises
consisting of approximately 11,048 square feet of space (the "Original
Premises") located in an office/warehouse building commonly known as Westpoint
Business Center (the "Park"), Building C, 13845 Industrial Park Boulevard,
Plymouth, Minnesota 55441; and

         WHEREAS, Landlord and Tenant desire to expand the Original Premises;
and

         WHEREAS, Landlord and Tenant desire to extend the Lease Term through
April 30, 2009; and

         WHEREAS, Landlord and Tenant desire to amend certain provisions of the
Lease to reflect such expansion and extension and any other changes to the
Lease, all as more particularly set forth herein;

         NOW, THEREFORE, in consideration of the foregoing premises, the mutual
covenants herein contained and each act performed hereunder by the parties,
Landlord and Tenant hereby enter into this Amendment.

         1. INCORPORATION OF RECITALS. The above recitals are hereby
incorporated into this Amendment as if fully set forth herein.

         2. EXTENSION OF TERM. The Lease Term is hereby extended through April
30, 2009.

         3. AMENDMENT OF ARTICLE 1. LEASE OF PREMISES. Commencing May 1, 2004,
ARTICLE 1 of the Lease is hereby amended as follows:

                  (a) SECTION 1.01 A of the Lease is hereby amended by
substituting AMENDED EXHIBIT A, attached hereto and incorporated herein by
reference, on which the Original Premises are striped and the additional space
containing approximately 4,790 square feet (the "Additional Space") is
cross-hatched, in lieu of EXHIBIT A attached to the Lease. The Original Premises
and Additional Space shall hereinafter be referred to as the "Leased Premises";

                  (b) SECTION 1.01, subsections B, C, D, E, G, J, K and M of the
Lease are hereby deleted in their entirety and the following are substituted in
lieu thereof:

         "B.      Rentable Area:

                  Original Premises:        approximately 11,048 square feet
                  Additional Space:         approximately   4,790 square feet

                  Total Leased Premises:    approximately 15,838 square feet;

                  Landlord shall use commercially reasonable standards,
                  consistently applied, in determining the Rentable Area and the
                  rentable area of the Building. Landlord's determination of
                  Rentable Area shall conclusively be deemed correct for all
                  purposes hereunder.

         C.       Building Expense Percentage:  24.85%;

         D.       Minimum Annual Rent:

                  05/01/04* - 04/30/06           $126,704.00* per year
                  05/01/06 - 04/30/09            $130,663.50 per year;

                  *For the period from May 1, 2004 through the Additional Space
                  Commencement Date (defined in Exhibit B attached hereto), the
                  Minimum Annual Rent shall be an amount equal to $88,384.00.

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         E.       Monthly Rental Installments:

                  05/01/04* - 04/30/06           $10,558.67 per month*
                  05/01/06 - 04/30/09            $10,888.63 per month;

                  *For the period from May 1, 2004 through the Additional Space
                  Commencement Date, the Monthly Rental Installment shall be an
                  amount equal to $7,365.34.

         G.       Lease Term: extended through April 30, 2009;

         J.       Guarantor: Cardiotech International, Inc., a Massachusetts
                  corporation;

         K.       Broker: Duke Realty Limited Partnership representing Landlord
                  and none representing Tenant;

         M.       Addresses for payments and notices:

                  Landlord:            Duke Realty Limited Partnership
                                       1600 Utica Avenue South, Suite 250
                                       Minneapolis, MN 55416

                  With Payments to:    Duke Realty Limited Partnership
                                       75 Remittance Drive, Suite 3205
                                       Chicago, IL 60675-3205

                  Tenant:              Catheter and Disposable Technology, Inc.
                                       13845 Industrial Park Boulevard
                                       Plymouth, MN 55441"

         4. AMENDMENT OF ARTICLE 2. TERM AND POSSESSION. ARTICLE 2, SECTION 2.02
of the Lease is hereby amended by adding the following new paragraphs:

"Tenant has personally inspected the Additional Space and accepts the same "AS
IS" without representation or warranty by Landlord of any kind and with the
understanding that Landlord shall have no responsibility with respect thereto
except for Landlord's obligation to construct and install all leasehold
improvements to the Leased Premises (together with all construction and
installation being performed by Landlord in accordance with this Agreement to
the Original Premises, the "Tenant Improvements") in accordance with EXHIBIT B-1
attached hereto and made a part hereof."

         5. AMENDMENT OF ARTICLE 16. RIGHT OF FIRST OFFER and ONGOING OPTION TO
TERMINATE. New SECTIONS 16.13 and 16.14 are hereby added to the Lease as
follows:

                  SECTION 16.13. RIGHT OF FIRST OFFER. (a) Provided that (i)
         Tenant has not been in Default hereunder at any time during the Lease
         Term that has not been cured by Tenant to Landlord's reasonable
         satisfaction or waived in writing by Landlord, (ii) the
         creditworthiness of Tenant is then reasonably acceptable to Landlord,
         (iii) Tenant originally named herein remains in possession of and has
         been continuously operating in the entire Leased Premises throughout
         the Lease Term, and (iv) the current use of the Leased Premises has not
         materially changed since the Commencement Date, and subject to any
         rights of any other tenant currently occupying all or any portion of
         the Offer Space, Landlord shall, before entering into a lease with a
         third party for the contiguous space crosshatched on the attached
         EXHIBIT A-1 (the "Offer Space"), notify Tenant in writing of the
         availability of such space for leasing ("Landlord's Notice") and
         provide Tenant with a written offer sheet providing Landlord's proposed
         rental amount and tenant improvements, if any. Tenant shall have five
         (5) business days from its receipt of Landlord's Notice to deliver to
         Landlord a written notice agreeing to lease such space on the terms and
         conditions contained in Landlord's Notice. In the event Tenant fails to
         notify Landlord of its agreement within said five (5) day period, such
         failure shall be conclusively deemed a rejection of the Offer Space,
         whereupon Tenant shall have no further rights with respect to the Offer
         Space and Landlord shall be free to lease the Offer Space to a third
         party. The term for the Offer Space shall be coterminous with the

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         term for the original Leased Premises; provided, however, that the
         minimum term for the Offer Space shall be three (3) years and the term
         for the original Leased Premises shall be extended, if necessary, to be
         coterminous with the term for the Offer Space.

                  (b) If, after Tenant either rejects the Offer Space or is
         deemed to have rejected the Offer Space, Landlord has not leased the
         Offer Space to a third party within six (6) months after Tenant's
         rejection or deemed rejection of the Offer Space, Landlord shall, prior
         to leasing the Offer Space to a third party, again offer the Offer
         Space to Tenant pursuant to the terms of Section 16.13(a).

                  Section 16.14. ONGOING OPTION TO TERMINATE. Provided Tenant
         (A) is not in Default hereunder that is then continuing; and (B) enters
         into an agreement with Landlord or an affiliate of Landlord to expand
         its business operations by leasing space containing more rentable
         square feet than the Leased Premises in another building which is (i)
         located within the greater Minneapolis/St. Paul, Minnesota area; and
         (ii) owned by Landlord or an affiliate of Landlord, Tenant shall have
         the option to terminate this Lease effective as of the commencement
         date (regardless of the date rent is due) under the new lease. If such
         option is validly exercised, then upon such termination, Tenant shall
         surrender the Leased Premises to Landlord in accordance with the terms
         of this Lease and each party shall be released from further liability
         hereunder; provided, however, that such termination shall not affect
         any right or obligation arising prior to termination or which survives
         termination of the Lease. Landlord hereby agrees to use commercially
         reasonable efforts to accommodate Tenant's expansion needs by locating
         space in another building located within the greater Minneapolis/St.
         Paul, Minnesota area owned by Landlord or an affiliate of Landlord, if
         available.

         6. BROKER. Tenant represents and warrants that, except for Duke Realty
Limited Partnership, no real estate broker or brokers were involved in the
negotiation and execution of this Amendment. Tenant shall indemnify Landlord and
hold it harmless from any and all liability for the breach of any such
representation and warranty on its part and shall pay any compensation to any
other broker or person who may be deemed or held to be entitled thereto.
Landlord represents and warrants that, except for Duke Realty Limited
Partnership, no real estate broker or brokers were involved in the negotiation
and execution of this Amendment. Landlord shall indemnify Tenant and hold it
harmless from any and all liability for the breach of any such representation
and warranty on its part and shall pay any compensation to any other broker or
person who may be deemed or held to be entitled thereto.

         7. TENANT'S REPRESENTATIONS AND WARRANTIES. The undersigned represents
and warrants to Landlord that (i) Tenant is duly organized, validly existing and
in good standing in accordance with the laws of the state under which it was
organized; (ii) all action necessary to authorize the execution of this
Amendment has been taken by Tenant; and (iii) the individual executing and
delivering this Amendment on behalf of Tenant has been authorized to do so, and
such execution and delivery shall bind Tenant.

         8. EXAMINATION OF AMENDMENT. Submission of this instrument for
examination or signature to Tenant does not constitute a reservation or option,
and it is not effective until execution by and delivery to both Landlord and
Tenant.

         9. DEFINITIONS. Except as otherwise provided herein, the capitalized
terms used in this Amendment shall have the definitions set forth in the Lease.

         10. INCORPORATION. This Amendment shall be incorporated into and made a
part of the Lease, and all provisions of the Lease not expressly modified or
amended hereby shall remain in full force and effect.

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         IN WITNESS WHEREOF, the parties have caused this Amendment to be
executed on the day and year first written above.

                                    LANDLORD:

                                    DUKE REALTY LIMITED PARTNERSHIP,
                                    an Indiana limited partnership

                                    By:  Duke Realty Corporation,
                                         its general partner

                                         By: _________________________________
                                                   Patrick E. Mascia
                                                   Senior Vice President

                                    TENANT:

                                    CATHETER AND DISPOSABLE TECHNOLOGY, INC.,
                                    a Minnesota corporation

                                    By:_______________________________

                                    Printed:____________________________

                                    Title:______________________________

STATE OF _________________ )
                           ) SS:
COUNTY OF ________________ )

         Before me, a Notary Public in and for said County and State, personally
appeared ______________________, by me known and by me known to be the
_________________________ of Catheter and Disposable Technology, Inc., a
Minnesota corporation, who acknowledged the execution of the foregoing "First
Lease Amendment" on behalf of said corporation.

         WITNESS my hand and Notarial Seal this ____ day of _____________, 2004.

                                               ---------------------------------
                                               Notary Public

                                               ---------------------------------
                                               (Printed Signature)

My Commission Expires:  _________________

My County of Residence: _________________

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                              CONSENT OF GUARANTOR

           The undersigned Guarantor to the Lease hereby consents to the
foregoing First Lease Amendment and reaffirms that the Guaranty of Lease dated
May 31, 2001 remains in full force and effect.

                                    "Guarantor"

                                    CARDIOTECH INTERNATIONAL, INC.,
                                    Massachusetts corporation

                                    By: _______________________________

                                    Printed: ____________________________

                                    Title: ______________________________

                                    Federal Identification Number:  04-3186647

STATE OF ________________)
                         )SS:
COUNTY OF _______________)

           Before me, a Notary Public in and for said County and State,
personally appeared __________________, by me known to be the
____________________________ of Cardiotech International, Inc., a Massachusetts
corporation, who acknowledged execution of the foregoing "Consent of Guarantor"
on behalf of said corporation.

           Witness my hand and Notarial Seal this ____ day of ___________, 2004.

                                                  -----------------------------
                                                  Notary Public

                                                  -----------------------------
                                                  (Printed Signature)

My Commission Expires:  _____________________

My County of Residence: _____________________

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                                    EXHIBIT B

                               TENANT IMPROVEMENTS

         1. LANDLORD'S OBLIGATIONS. Tenant has personally inspected the Leased
Premises and accepts the same "AS IS" without representation or warranty by
Landlord of any kind and with the understanding that, except as otherwise set
forth in the Lease, Landlord shall have no responsibility with respect thereto
except to construct and install within the Leased Premises, in a good and
workmanlike manner, the Tenant Improvements, in accordance with this EXHIBIT B.

         2. CONSTRUCTION DRAWINGS. On or before the thirtieth (30th) day
following the date hereof, Landlord shall prepare and submit to Tenant a set of
construction drawings (the "CD's") covering all work to be performed by Landlord
in constructing and installing the Tenant Improvements, which shall be based on
the scope of work attached as EXHIBIT B-1 hereto. Tenant shall have ten (10)
days after receipt of the CD's in which to review the CD's and to give to
Landlord written notice of Tenant's approval of the CD's or its requested
changes to the CD's. Tenant shall have no right to request any changes to the
CD's that would increase the scope of work or materially alter the exterior
appearance or basic nature of the Building or the Building systems. If Tenant
fails to approve or request changes to the CD's within ten (10) days after its
receipt thereof, Tenant shall be deemed to have approved the CD's and the same
shall thereupon be final. If Tenant requests any changes to the CD's, Landlord
shall make those changes which are reasonably requested by Tenant and shall
within ten (10) days of its receipt of such request submit the revised portion
of the CD's to Tenant. Tenant may not thereafter disapprove the revised portions
of the CD's unless Landlord has unreasonably failed to incorporate reasonable
comments of Tenant and, subject to the foregoing, the CD's, as modified by said
revisions, shall be deemed to be final upon the submission of said revisions to
Tenant. Tenant shall at all times in its review of the CD's, and of any
revisions thereto, act reasonably and in good faith. Without limiting the
foregoing, Tenant agrees to confirm Tenant's consent to the CD's in writing
within three (3) days following Landlord's written request therefor.

         3. SCHEDULE AND EARLY OCCUPANCY. Landlord shall provide Tenant with a
proposed schedule for the construction and installation of the Tenant
Improvements (including the work to the Original Premises) and shall notify
Tenant of any material changes to said schedule; provided, however, that the
Tenant Improvements shall be completed in three (3) separate stages pursuant to
the schedule delivered to Tenant. The first such stage, being the Tenant
Improvements relating to the Additional Space, shall be Substantially Completed
on or before the date which is two (2) months after the date the Construction
Drawings are completed in accordance with Section 2 of this Exhibit B and all
necessary building permits have been received (the "Additional Space Target
Commencement Date"). The second such stage shall be Substantially Completed
within sixty (60) days after work on the second stage commences and the third
such stage shall be Substantially Completed within sixty (60) days after work on
the third stage commences. Landlord shall commence, and Tenant agrees to permit
Landlord to enter the Leased Premises to perform, work (i) on the second stage
of the Tenant Improvements not later than ten (10) days after the Additional
Space Target Commencement Date and (ii) on the third stage not later than ten
(10) days after the Substantial Completion of the second stage of the Tenant
Improvements. Landlord acknowledges that it shall be responsible for acquiring
all licenses, permits, and certificates of occupancy necessary for the
construction and installation of the Tenant Improvements (including the work to
the Original Premises) and shall make a diligent effort to obtain all such
permits as timely as practicable. Except for punchlist type items and subject to
Tenant Delays, if Landlord fails to deliver the Additional Space by the
Additional Space Target Commencement Date, that portion of the Monthly Rental
Installments as relates to the Additional Space shall abate at the rate of one
(1) day for every one (1) day of such delay in delivering possession of the
Additional Space. Tenant agrees to coordinate with Landlord regarding the
installation of Tenant's phone and data wiring and any other trade related
fixtures that will need to be installed in the Additional Space prior to
Substantial Completion of the Tenant Improvements to the Additional Space. In
addition, if and to the extent permitted by applicable laws, rules and
ordinances, Tenant shall have the right to enter the Additional Space for
fifteen (15) days prior to the scheduled date for Substantial Completion of the
Tenant Improvements in the Additional Space in order to install fixtures (such
as racking) and otherwise prepare the Additional Space for occupancy, which
right shall expressly exclude making any structural modifications. During any
entry to the Additional Space prior to the Additional Space Commencement Date
(a) Tenant shall comply with all terms and conditions of this Lease, (b) Tenant
shall not interfere with Landlord's completion of the Tenant Improvements in the
Additional Space, (c) Tenant shall cause its personnel and contractors to comply
with the terms and conditions of Landlord's rules of conduct (which Landlord
agrees to furnish to Tenant upon request), and (d) Tenant shall not begin
operation of its business in the Additional Space. Tenant acknowledges that
Tenant shall be responsible for obtaining all applicable permits and inspections
relating to any such entry by Tenant. Except for punchlist-type items and
subject to Tenant Delays, if Landlord fails to complete the construction and
installation of the renovations to the Original

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Improvements by the time set forth in this Exhibit B, Section 3, Monthly Rental
Installments shall abate by an amount equal to the pro-rata rental of the square
footage of the Leased Premises under construction and which cannot be occupied
by Tenant for its business operations due to such construction.

         4. CHANGE ORDERS. Tenant shall have the right to request changes to the
CD's at any time following the date hereof by way of written change order (each,
a "Change Order", and collectively, "Change Orders"). Provided such Change Order
is reasonably acceptable to Landlord, Landlord shall prepare and submit promptly
to Tenant a memorandum setting forth the impact on cost and schedule resulting
from said Change Order (the "Change Order Memorandum of Agreement"). Tenant
shall, within seven (7) days following Tenant's receipt of the Change Order
Memorandum of Agreement, either (a) execute and return the Change Order
Memorandum of Agreement to Landlord, or (b) retract its request for the Change
Order. At Landlord's option, Tenant shall pay to Landlord (or Landlord's
designee), within ten (10) days following Landlord's request, any increase in
the cost to construct the Tenant Improvements resulting from the Change Order,
as set forth in the Change Order Memorandum of Agreement. Landlord shall not be
obligated to commence any work set forth in a Change Order until such time as
Tenant has delivered to Landlord the Change Order Memorandum of Agreement
executed by Tenant and, if required by Landlord due to any material Change
Order, Tenant has paid Landlord in full for said Change Order.

         5. TENANT DELAY. Notwithstanding anything to the contrary contained in
the Lease, if Substantial Completion of the Tenant Improvements is delayed
beyond the Additional Space Target Commencement Date as a result of Tenant Delay
(as hereinafter defined), then, for purposes of determining the Commencement
Date, Substantial Completion of the Tenant Improvements to the Additional Space
shall be deemed to have occurred on the date that Substantial Completion of the
Tenant Improvements to the Additional Space would have occurred but for such
Tenant Delay. Without limiting the foregoing, Landlord shall use commercially
reasonable speed and diligence to Substantially Complete the Tenant Improvements
on or before the Additional Space Target Commencement Date.

         6. LETTER OF UNDERSTANDING. Promptly following the Additional Space
Commencement Date, Tenant shall execute Landlord's Letter of Understanding in
substantially the form attached hereto as EXHIBIT C and made a part hereof,
acknowledging (a) the Additional Space Commencement Date under this Lease, and
(b) except for any punchlist items, that Tenant has accepted the Additional
Space. If Tenant takes possession of and occupies the Additional Space, Tenant
shall be deemed to have accepted the Additional Space and that the condition of
the Additional Space and the Building was at the time satisfactory and in
conformity with the provisions of this Lease in all respects, subject to any
punchlist items. Landlord shall use reasonable efforts to complete the punchlist
items within thirty (30) days of such notice. Landlord agrees to devote proper
attention to punchlist items as would be given to similarly situated buildings.

           7. DEFINITIONS. For purposes of this Lease (a) "Substantial
Completion" (or any grammatical variation thereof) shall mean completion of
construction of the Tenant Improvements, subject only to punchlist items to be
identified by Landlord and Tenant in a joint inspection of the Leased Premises
prior to Tenant's occupancy, as established by a certificate of occupancy for
the Leased Premises or other similar authorization issued by the appropriate
governmental authority, if required, (b) "Tenant Delay" shall mean any delay in
the completion of the Tenant Improvements attributable to Tenant, including,
without limitation (i) Tenant's failure to meet any time deadlines specified
herein, (ii) Change Orders, (iii) the performance of any other work in the
Leased Premises by any person, firm or corporation employed by or on behalf of
Tenant, or any failure to complete or delay in completion of such work, (iv)
Landlord's inability to obtain an occupancy permit for the Leased Premises
because of the need for completion of all or a portion of improvements being
installed in the Leased Premises directly by Tenant, and (v) any other negligent
act or willful omission of Tenant, and (c) "Additional Space Commencement Date"
shall mean the date upon which the Tenant Improvements to the Additional Space
are Substantially Completed.<Page>

                                                                   Exhibit 10.21

                          EXCHANGE & VENTURE AGREEMENT

                                  by and among

                         CARDIOTECH INTERNATIONAL, INC.,

                             IMPLANT SCIENCES, INC.

                                      and

                                 CORNOVA, INC.

                                 March 5, 2004

CorNova agreement as signed.doc

<Page>

                          EXCHANGE & VENTURE AGREEMENT

This EXCHANGE & VENTURE AGREEMENT dated March 5, 2004 ("AGREEMENT") by and among
CARDIOTECH INTERNATIONAL, INC. ("CARDIOTECH"), a Delaware corporation with its
principal executive offices at 78E Olympia Avenue, Woburn, Massachusetts 01801,
(AMEX: CTE), and IMPLANT SCIENCES, INC. ("IMPLANT"), a Delaware corporation with
its principal executive offices at 107 Audubon Road #5, Wakefield, Massachusetts
01880, (AMEX: IMX); (Cardiotech and Implant are collectively referred to herein
as the "PARTICIPANTS "), and CORNOVA, INC., a Delaware corporation with its
principal executive offices at 274 Ash Street, Hopkinton, Massachusetts 01748
(the "COMPANY" or "CorNova").

                                R E C I T A L S :

      FINANCING AND SHARE EXCHANGE

         WHEREAS, the Participants wish to contribute certain of their shares to
the Company in exchange for shares of the Company in accordance with the terms
and conditions hereinafter set forth.

         WHEREAS, the Participants will issue shares of their common stock
bearing an aggregate fair market value of one hundred fifty thousand dollars
($150,000) valued at the end of business on November 18, 2003 to CorNova as
follows: Cardiotech will issue 12,931 shares, and Implant will issue 10,344
shares (the 12,931 and 10,344 shares shall be referred to collectively as the
"CONTRIBUTORY SHARES").

         WHEREAS, CorNova, upon receipt of the Contributory Shares, shall
simultaneously issue and deliver one million five hundred thousand (1,500,000)
shares of its common stock to each of Cardiotech and Implant, such shares
constituting sixty percent (60%) of CorNova's issued and outstanding shares, on
a fully diluted basis, as of the date of issuance.

         WHEREAS, CorNova will use its best efforts to borrow a minimum of fifty
thousand dollars ($50,000) and up to one hundred fifty thousand dollars
($150,000) in seed capital in 2004 to finance the startup of its operations
("SEED LOANS").

         WHEREAS, CorNova intends to raise a minimum of one million dollars
($1,000,000) and up to three million dollars ($3,000,000) in a Series A
financing round to close in 2004 ("SERIES A FINANCING").

         WHEREAS, upon the closing of the minimum Series A Financing, the
Participants will each issue shares of their common stock equal to up to
twenty-five percent (25%) of the gross amount of the Series A Financing up to
the maximum of three

<Page>

CorNova, Inc.
Exchange & Venture Agreement
Page 2

million dollars ($3,000,000) (the "INVESTMENT SHARES"); bearing an aggregate
fair market value of up to one million five hundred thousand dollars
($1,500,000) valued at the end of business on the day immediately preceding the
date of the Series A Financing Closing.

      TECHNOLOGY & VENTURE

         WHEREAS, CorNova is a start-up company, which has not incurred any
debts or liabilities in excess of fifty thousand dollars ($50,000) in the
aggregate, focused on the development and marketing of innovative interventional
cardiology products. The initial target of CorNova is the development of a
next-generation drug-eluting stent.

         WHEREAS, CorNova possesses, will develop or will acquire the
intellectual property relating to stent design, CE testing and drug coatings.

         WHEREAS, Cardiotech intends to grant to CorNova an exclusive license
for the technology consisting of Chronoflex DES polymer or any poly (carbonate)
urethane and containing derivative thereof solely for use on drug-eluting
stents.

         WHEREAS, Utilizing the combined capabilities of the Participants,
CorNova will seek to produce a novel coronary stent system whose design,
materials, and manufacturing will be specific for drug elution technology.

         NOW THEREFORE, in consideration of one dollar and the exchange of
shares to be made, the mutual benefits to be derived hereby and the
representations, warranties, covenants and agreements herein contained, and for
other good and valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, CorNova and the Participants agree as follows:

                         ARTICLE I. CONTRIBUTORY SHARES

1.1 CARDIOTECH CONTRIBUTORY SHARES.

  Subject to the terms and conditions hereinafter set forth, Cardiotech shall
issue, transfer and deliver to CorNova an aggregate of twelve thousand nine
hundred thirty-one (*12,931*) shares of Cardiotech common stock, $.01 par value
(the "CARDIOTECH CONTRIBUTORY SHARES") within fifteen (15) days of the execution
of this Agreement. Upon receipt of the Cardiotech Contributory Shares, the
Company shall simultaneously issue and deliver 1,500,000 shares of its common
stock to Cardiotech, such shares constituting thirty percent (30%) of CorNova's
issued and outstanding shares, on a fully diluted basis, as of the date of
issuance.

<Page>

CorNova, Inc.
Exchange & Venture Agreement
Page 3

1.2 IMPLANT CONTRIBUTORY SHARES.

  Subject to the terms and conditions hereinafter set forth, Implant shall
issue, transfer and deliver to CorNova an aggregate of ten thousand three
hundred forty-forty (*10,344*) shares of Implant common stock, $.10 par value
(the "IMPLANT CONTRIBUTORY SHARES") within fifteen (15) days of the execution of
this Agreement. Upon receipt of the Implant Contributory Shares, the Company
shall simultaneously issue and deliver 1,500,000 shares of its common stock to
Implant, such shares constituting thirty percent (30%) of CorNova's issued and
outstanding shares, on a fully diluted basis, as of the date of issuance.

1.3 TERMS OF CONTRIBUTORY SHARES.

  The Cardiotech Contributory Shares and the Implant Contributory Shares shall
be referred to collectively herein as the "CONTRIBUTORY SHARES". The
Contributory Shares shall have the terms and be issued subject to the conditions
as set forth herein and in the respective certificates of incorporation of the
Participants as filed and recorded with the Secretary of State of the State of
Delaware. The Contributory Shares shall be contributed to CorNova to assist in
securing the Seed Loans and to serve as collateral against such loans in
anticipation of the Participants respective anticipated participation in CorNova
and Technology.

            ARTICLE II. CORNOVA OBLIGATIONS UPON CONTRIBUTORY SHARES

II-A. Simultaneous with receipt of the Contributory Shares by CorNova:

2.1 SEED LOANS. CorNova shall use its best efforts to borrow a minimum of fifty
thousand dollars ($50,000) and up to one hundred fifty thousand dollars
($150,000) in seed capital in 2004 to finance the startup of its operations
("SEED LOANS") under the following terms and conditions:

         (a) The Seed Loans shall become due and payable fifteen months from
receipt of the loan.

         (b) The Seed Loans shall bear simple interest at an annual rate of ten
percent (10%).

         (c) The Seed Loans shall be secured by the Contributory Shares, as
defined below.

         (d) The lenders making the Seed Loans shall be issued warrants in
proportion to the amount of all of the Seed Loans made. Assuming the maximum
Seed Loans, the Seed Loan lender(s) shall receive an aggregate of one hundred
fifty thousand (150,000) warrants ("WARRANTS"). The Warrants shall entitle the
holders thereof to purchase, in the aggregate, one hundred fifty thousand
(150,000) shares of common stock of CorNova on or before January 5, 2007. The
number of Warrants shall be reduced on a dollar-for-dollar basis based on the
size of the Seed Loans. The exercise price of each of the Warrants shall be one
hundred twenty percent (120%) of the fair market value of the shares of CorNova
as of the date of the closing of the Seed Loans as determined in the reasonable
discretion of by the board of directors of CorNova.

         (e) The proceeds of the Seed Loans and the exercise of the Warrants
shall be used for start-up capital, expenses of the Series A Preferred stock
capital raise, initial monthly salary of the chairman of CorNova, professional
fees, and general working capital purposes.

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         (f) The capitalization of CorNova shall not exceed five million
(5,000,000) shares of common stock on a fully diluted basis, including the
shares of common stock underlying the Warrants, immediately following the
issuance of the Contributory Shares.

         (g) The lenders making the Seed Loans shall qualify as accredited
investors under the Securities Laws.

         (h) Such other terms and conditions as set forth in the form
Subscription and Loan Agreements and the Shareholder-Lender Promissory Notes
evidencing the Seed Loans.

II-B. Upon receipt of the Contributory Shares by CorNova:

2.2 BOARD REPRESENTATION. CorNova shall, by written consent of a majority of the
shareholders of CorNova, increase the size of its board and appoint Dr. Michael
Szycher and Dr. Anthony J. Armini to be directors of CorNova on its board of
directors. The board of directors of CorNova shall then be entirely comprised
of: Dr. Stephen Eric Ryan, Dr. Michael Szycher and Dr. Anthony J. Armini.

2.3 CHAIRMAN & CEO COMPENSATION. (a) Upon closing of the minimum Seed Loans,
CorNova shall provide monthly compensation to S. Eric Ryan, pursuant to the
conditions set forth in the consulting agreement attached hereto as EXHIBIT 2.3,
for his services as CEO of CorNova at the monthly rate of eight thousand dollars
($8,000). CorNova shall also provide up to one thousand dollars ($1,000) per
month for health insurance for S. Eric Ryan and his family upon the closing of
the minimum Seed Loans. Upon closing of the at least the minimum Series A
Financing the consulting agreement will expire.

         (b) CorNova shall negotiate a separate employment agreement with S.
Eric Ryan for the continuation of his services as Chairman and CEO with a base
salary of at least fifteen thousand dollars ($15,000) per month. CorNova shall
also provide up to $1,000 per month for health insurance for S. Eric Ryan and
his family. Such employment agreement is to commence after expiration of the
consulting agreement and upon the closing of at least the minimum Series A
Financing. Further, Dr. Ryan will be paid a bonus equal to one full year of his
full salary upon either (a) receipt by CorNova of the release and discharge of
the security interests which are to be filed against the Investment Shares in
favor of the Series A Investors, or (b) the occurrence of an event requiring
mandatory conversion of the then outstanding preferred stock of CorNova.

2.4 SERIES A OFFERING. CorNova shall commence on a best efforts basis its Series
A Financing, as hereinafter defined, under the following terms and conditions:

         (a) The Series A Financing shall commence within thirty (30) days of
the closing of the

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Seed Loans and shall be completed or terminated twelve (12) months after such
commencement date; however, CorNova shall have an additional thirty (30) days
after the completion or termination date to close on any then outstanding
subscriptions to purchase any Series A Preferred Stock.

         (b) CorNova shall amend its certificate of incorporation to provide for
a series of convertible voting preferred stock ("SERIES A PREFERRED STOCK")
which shall be the securities offered and sold in the Series A Financing.

         (c) The purchase price per share of the Series A Preferred Stock is
proposed to equal one dollar 20/100 ($1.20) (the "SERIES A PRICE").

         (d) The Series A Preferred Stock shall not be sold for less than one
dollar ($1.00) per share without the express written agreement of the board of
directors of CorNova.

         (e) The conversion price of the Series A Preferred Stock shall be
convertible at no cost to the Series A Preferred holder (the "CONVERSION
PRICE"). Each share of Preferred Stock shall be convertible at the option of the
holder into one (1) share of fully paid and nonassessable shares of the common
stock of CorNova.

         (f) Conversion of the Series A Preferred Stock will be mandatory upon
an initial public offering of CorNova raising in excess of ten million dollars
($10,000,000), or an acquisition for at least eighty percent (80%) of CorNova at
a minimum purchase price of two dollars 50/100 ($2.50) per share, or upon
receipt of CE mark approval of the Technology.

         (g) The Series A Financing offering shall consist of a minimum of one
million dollars ($1,000,000) and a maximum of three million dollars
($3,000,000).

         (h) CorNova does not anticipate that the holders of the Series A
Preferred Stock shall be entitled to dividend, and the designation for the
Series A Preferred Stock shall not be amended without the express written
agreement of the board of directors of CorNova.

         (i) The liquidation preference of the Series A Preferred Stock shall be
equal to the Series A Price.

         (j) The redemption rate of the Series A Preferred Stock shall not
exceed one and 50/100 ($1.50) dollars per share without the express written
agreement of the board of directors of CorNova.

         (k) The investors of the Series A Financing shall receive a senior
security interest in the Investment Shares (collectively "SERIES A SECURED
INTEREST") subject to certain terms and conditions.

         (l) The Series A Secured Interest shall be equal in all respects and of
equal parity, position and priority as among each Series A Financing investor.

         (m) The Series A Secured Interest shall expire and be released upon
CorNova achieving either of two milestones: (i) CorNova securing a CE mark, or
such other European authority approval, of a bare coronary stent system, and/or
(ii) preclinical demonstration of a drug-eluting stent yielding results of at
least a fifty percent (50%) reduction in intimal hyperplasia.

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II-C.

2.5 RESCISSION AND TERMINATION IF NO MINIMUM SEED LOANS. In the event the
closing of at least the minimum Seed Loans has not occurred within ninety (90)
days of the date of this Agreement, the Participants shall together have the
right to rescind and terminate this Agreement. Upon such rescission and
termination by both Participants, the Participants shall each return for
cancellation the CorNova Shares in exchange for the Contributory Shares. Upon
receipt by CorNova of written notice from both Participants and receipt by
CorNova of the CorNova Shares, CorNova shall immediately return and deliver: (a)
all of the Cardiotech Shares to Cardiotech, and (b) all of the Implant Shares to
Implant. Immediately thereafter, this Agreement shall be of no force and effect.

                         ARTICLE III. INVESTMENT SHARES

3.1 CARDIOTECH INVESTMENT SHARES. Upon CorNova securing the minimum Series A
Financing subject to the terms and conditions hereinafter set forth, Cardiotech
shall issue, transfer and deliver to CorNova an amount of Cardiotech common
stock, $.01 par value, (the "CARDIOTECH INVESTMENT SHARES") which amount shall
be calculated based upon the five (5) day average of the fair market value of
the closing price of Cardiotech common stock as published in the WALL STREET
JOURNAL on the dates immediately preceding each relevant closing of the Series A
Financing. The amount of the Cardiotech Investment Shares shall be equal to
twenty-five percent (25%) of the gross dollar amount of the Series A Financing
raised and invested in CorNova on a PRO RATA basis up to the maximum Series A
Financing amount. Thus, Cardiotech will be obligated to issue and deliver to
CorNova the Cardiotech Investment Shares equal to two hundred fifty thousand
dollars ($250,000) in value if the minimum Series A Financing is completed; and
Cardiotech will be obligated to issue and deliver to CorNova the Cardiotech
Investment Shares equal to seven hundred fifty thousand dollars ($750,000) in
value if the maximum Series A Financing is completed. In the event the Series A
Financing exceeds its maximum of three million dollars ($3,000,000), Cardiotech
shall be obligated to only contribute Cardiotech Investment Shares equal to
seven hundred fifty thousand dollars ($750,000) in value.

3.2 IMPLANT INVESTMENT SHARES. Upon CorNova securing the minimum Series A
Financing subject to the terms and conditions hereinafter set forth, Implant
shall issue, transfer and deliver to CorNova an amount of Implant common stock,
$.10 par value, (the "IMPLANT INVESTMENT SHARES") which amount shall be
calculated based upon the five (5) day average of the fair market value of the
closing price of Implant common stock as published in the WALL STREET JOURNAL on
the dates immediately preceding each relevant closing of the Series A Financing.
The amount of the Implant Investment Shares shall be equal to twenty-five
percent (25%) of the gross dollar amount of the Series A Financing raised and
invested in CorNova on a PRO RATA basis up to the maximum Series A Financing
amount. Thus, Implant will be obligated to issue and deliver to CorNova the
Implant Investment Shares equal to two hundred fifty thousand dollars ($250,000)
in value if the minimum Series A Financing is completed; and Implant will be
obligated to issue and deliver to CorNova the Implant Investment Shares equal to
seven hundred fifty thousand dollars ($750,000) in value if the maximum Series A
Financing is completed. In the event the

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Series A Financing exceeds its maximum of three million dollars ($3,000,000),
Implant shall be obligated to only contribute Implant Investment Shares equal to
seven hundred fifty thousand dollars ($750,000) in value.

3.3 INVESTMENT SHARES. The Cardiotech Investment Shares and the Implant
Investment Shares shall be referred to collectively herein as the "INVESTMENT
SHARES". The Investment Shares shall be issued subject to the conditions as set
forth herein and in the respective certificates of incorporation of the
Participants as filed and recorded with the Secretary of State of the State of
Massachusetts.

3.4 SUBSEQUENT TRANCHES OF INVESTMENT SHARES. (a) The offering of the Series A
Financing may be continued until the maximum amount of capital has been raised,
but no later than February 28, 2005. At each subsequent closing tranche, the
Participants shall be obligated to issue Investment Shares as provided for under
this Article III to maintain its twenty-five percent (25%) PRO RATA portion of
the Investment Shares to be issued.

         (b) Upon CorNova securing additional Series A Financing up to the
maximum three million dollars ($3,000,000), each Participant shall issue,
transfer and deliver to CorNova its PRO RATA amount of its Investment Shares
which amount shall be calculated as set forth above. The amount of additional
Investment Shares from each Participant to be issued at each subsequent closing
tranche shall be that PRO RATA number of new shares separately combined with all
previous issuances of Investment Shares from each Participant which shall equal
twenty-five percent (25%) [fifty percent (50%) in the aggregate] of the gross
dollar amount of the Series A Financing raised and invested in CorNova up to
twenty-five percent (25%) [fifty percent (50%) in the aggregate] of the maximum
Series A Financing amount.

         (c) CorNova, at its option and in its sole discretion, may delay the
closing of the minimum Series A Financing, and each subsequent tranche closing,
in order to sell and close on a greater number Series A shares in each tranche;
provided that each closing occur no later than twelve (12) months from the date
of the closing of the minimum Seed Loans, plus 30 days for subscriptions then
existing but not then closed.

                           ARTICLE IV. CORNOVA SHARES

4.1 CORNOVA SHARES TO CARDIOTECH. Upon receipt by CorNova of the Contributory
Shares, CorNova shall simultaneously issue, and deliver to Cardiotech one
million five hundred thousand (*1,500,000*) shares of the common stock of
CorNova, par value $.0001 per share, representing thirty percent (30%) of the
issued and outstanding capital stock of CorNova immediately prior to the
issuance of any shares under the Series A Financing.

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4.2 CORNOVA SHARES TO IMPLANT. Upon receipt by CorNova of the Contributory
Shares, CorNova shall simultaneously issue, and deliver to Implant one million
five hundred thousand (*1,500,000*) shares of the common stock of CorNova, par
value $.0001 per share, representing thirty percent (30%) of the issued and
outstanding capital stock of CorNova immediately prior to the issuance of any
shares under the Series A Financing.

4.3 CORNOVA SHARES. The aggregate shares of the common stock of CorNova in an
amount of three million (3,000,000) shares to be issued to Cardiotech and
Implant shall be referred to herein as the "CORNOVA SHARES" and will equal sixty
percent (60%) of the issued and outstanding capital stock of CorNova, on a fully
diluted basis, including any shares underlying any warrants or options,
immediately prior to the issuance of any shares under the Series A Financing.

                         ARTICLE V. EXCHANGE OF SHARES

5.1 EXCHANGE OF SHARES. The Contributory Shares, Investment Shares and the
CorNova Shares shall be issued in accordance with Articles I, III and IV hereof,
and shall be exchanged in accordance with this Article V (the "EXCHANGE").

         (a) The Contributory Shares shall be delivered in accordance with
Article I, and the Contributory Shares shall be deemed exchanged upon such
event. However such shares shall be held by the Seed Loan lenders or by CorNova,
as trustee for such lenders as collateral subject to a security interest, and
may not be transferred or otherwise disposed of by CorNova prior to either the
minimum closing or the termination of the Series A Financing.

         (b) The Investment Shares shall be delivered in accordance with Article
III and shall be deemed exchanged upon the minimum closing of the Series A
Financing. However such shares shall be held by the Series A Financing investors
or by CorNova, as trustee for such investors as collateral subject to a security
interest, and may not be transferred or otherwise disposed of by CorNova prior
to satisfaction of the milestones set forth in Section 2.4(m) hereof.

         (c) The CorNova Shares shall be delivered in accordance with Article IV
and shall be deemed exchanged upon receipt and exchange of the Contributory
Shares.

         (d) The consideration for the Exchange shall be the shares mutually
delivered and exchanged as herein set forth, and the license of the Technology
as set forth in Article VIII hereof.

                  ARTICLE VI. SHARES, AND LIMITATIONS ON SHARES

6.1 SHARES TO BE FULLY PAID. (a) CorNova covenants that all shares of common
stock which may be issued upon the Exchange will be fully paid and
nonassessable, and free of all liens and encumbrances.

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         (b) Cardiotech covenants that all shares of common stock which may be
issued upon the Exchange will be fully paid and nonassessable, and free of all
liens and encumbrances.

         (c) Implant covenants that all shares of common stock which may be
issued upon the Exchange will be fully paid and nonassessable, and free of all
liens and encumbrances.

6.2 CORNOVA LIMITATION ON SHARE ISSUANCES. CorNova covenants that until either
the minimum Series A Financing closing or the termination of the Series A
Financing, CorNova shall not:

         (a) issue any securities, except: (i) its initial capitalization of 2
million shares which includes the 150,000 shares underlying those certain
warrants issued or to be issued in connection with the Seed Loans, (ii) the
CorNova Shares, and (iii) the shares to be issued under the Series A Financing.

         (b) take any action which would cause any adjustments,
recapitalizations, splits, mergers, or other capital restructurings of its
securities.

6.3 RESERVATION OF SHARES. (a) CorNova has reserved, free from preemptive
rights, out of its authorized but unissued shares of common stock, sufficient
shares to provide for the issuance of the CorNova Shares.

         (b) Cardiotech has reserved, free from preemptive rights, out of its
authorized but unissued shares of common stock, sufficient shares to provide for
the issuance of the Cardiotech Investment Shares.

         (c) Implant has reserved, free from preemptive rights, out of its
authorized but unissued shares of common stock, sufficient shares to provide for
the issuance of the Implant Investment Shares.

    ARTICLE VII. ACCREDITED INVESTORS; RESTRICTED SHARES; INSIDE INFORMATION

7.1 SECURITIES LAWS MATTERS.

         (a) INVESTMENT PURPOSE. CorNova recognizes and understands that the
Contributory Shares, and the Investment Shares, respectively, to be issued to
CorNova pursuant to this Agreement, and the Participants each recognize and
understand that the CorNova Shares to be issued to each of the Participants
pursuant to this Agreement, (collectively referred to as the "SECURITIES") for
investment and not with a view to the sale or distribution thereof, for its own
account and not on behalf of others (except its limited partners, or
shareholders) and has not granted any other person any right or option or any
participation or beneficial interest in any of the Securities. CorNova and each
of the Participants confirms its understanding that the Securities constitute
restricted securities

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within the meaning of Rule 144 of the Commission under the Securities Act of
1933, as amended (the "SECURITIES ACT"), and that none of the Securities may be
sold except pursuant to an effective registration statement under the Securities
Act or under the securities laws of any state, or in a transaction exempt from
registration under the Securities Act, and acknowledges that it understands the
meaning and effect of such restriction. CorNova and each of the Participants are
aware that no federal or state regulatory agency or authority has passed upon
the sale of the Securities or the terms of the sale or the accuracy or adequacy
of any material being provided to CorNova or to the Participants and that the
price of the Securities may not necessarily bear any relationship to the
underlying assets or value of the issuing company. CorNova understands that an
investment in the Securities involves a degree of risk. The Participants each
understand that an investment in the Securities involves a high degree of risk.
The Securities are not being registered; neither the Participants nor CorNova
shall have any obligation or duty to register the Securities. The Securities
will be issued in reliance upon exemptions from the Securities Act and the
securities laws which are predicated, in part, on the representations,
warranties and agreements of each of the Participants, and CorNova,
respectively, to the other, contained herein.

         (b-1) CORNOVA QUALIFICATIONS. CorNova represents and warrants that (i)
CorNova has business knowledge and experience, such experience being based on
actual participation therein of its chairman and its advisors, (ii) CorNova is
capable of evaluating the merits and risks of an investment in the Securities
and the suitability thereof as an investment therefor, (iii) the Securities to
be acquired by CorNova in connection with this Agreement will be acquired solely
for investment and not with a view toward resale or redistribution in violation
of the securities laws, and (iv) in connection with the transactions
contemplated hereby, no assurances have been made concerning the future results
of the Participants and their subsidiaries, if any, or as to the value of the
Securities. CorNova understands that neither of the Participants or its
subsidiaries or affiliates is under any obligation to file a registration
statement or to take any other action under the securities laws with respect to
any such securities.

         (b-2) PARTICIPANTS QUALIFICATIONS. The Participants represent and
warrant that (i) the Participants have business knowledge and experience, such
experience being based on actual participation therein, (ii) the Participants
are each independently capable of evaluating the merits and risks of an
investment in the Securities and the suitability thereof as an investment
therefor, (iii) the Securities to be acquired by each of the Participants in
connection with this Agreement will be acquired solely for investment and not
with a view toward resale or redistribution in violation of the securities laws,
(iv) in connection with the transactions contemplated hereby, no assurances have
been made concerning the future results of CorNova or as to the value of the
Securities and (vi) each of the Participants are an "accredited investor" within
the meaning of Regulation D promulgated by the Securities and Exchange
Commission (the "COMMISSION") pursuant to the 1933 Act. The Participants
understand that CorNova is closely-held and is not under any obligation to file
a registration statement or to take any other action under the securities laws
with respect to any such securities.

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         (c) KNOWLEDGE OF REGULATIONS. The Participants, and CorNova had each
consulted with their own respective counsel in regard to the securities laws and
are fully aware (i) of the circumstances under which they are each required to
hold the Securities, (ii) of the limitations on the transfer or disposition of
the Securities, (iii) that the Securities must be held indefinitely unless the
transfer thereof is registered under the securities laws or an exemption from
registration is available and (iv) that no exemption from registration is likely
to become available for at least one year from the date of acquisition of the
Securities. The Participants and CorNova have been advised by their respective
counsel as to the provisions of Rules 144 and 145 as promulgated by the
Commission under the 1933 Act and has been advised of the applicable limitations
thereof. The Participants and CorNova each independently acknowledge that the
respective issuers of the Securities are relying upon the truth and accuracy of
the representations and warranties in this Article VII in consummating the
transactions contemplated by this Agreement and upon such reliance shall not be
registering the Securities under the securities laws. The Participants each
independently acknowledge that CorNova is closely-held, and that no market
whatsoever exists with respect to any of CorNova's securities and there are no
plans to develop a market.

         (d-1) DISCLOSURES OF PARTICIPANTS. CorNova has been furnished with
copies through the Securities and Exchange Commission EDGAR website of: (i) the
definitive proxy statements filed with the Commission in connection with the
annual meeting of stockholders of each of Cardiotech and Implant during the
previous 12 months, and (ii) copies of the Cardiotech and Implant Annual Reports
on Form 10-K for the fiscal year most recently ended, Cardiotech and Implant
Quarterly Reports on Form 10-Q for the quarter most recently ended, filed with
the Commission under the Exchange Act, and all Cardiotech and Current Reports on
Form 8-K filed during the previous 12 months, as filed with the Commission under
the Exchange Act (collectively, the "SEC REPORTS"). The Participants have made
available to CorNova the opportunity to ask questions and receive answers
concerning the terms and conditions of the transactions contemplated by this
Agreement and to obtain any additional information which they possess or could
reasonably acquire for the purpose of verifying the accuracy of information
furnished to CorNova as set forth herein or for the purpose of considering the
transactions contemplated hereby.

         (d-2) DISCLOSURES OF CORNOVA. The Participants has been furnished with
a summary description of the terms of the Securities and CorNova has made
available to the Participants the opportunity to ask questions and receive
answers concerning the terms and conditions of the transactions contemplated by
this Agreement and to obtain any additional information which they possess or
could reasonably acquire for the purpose of verifying the accuracy of
information furnished to the Participants as set forth herein or for the purpose
of considering the transactions contemplated hereby.

         (e) OPPORTUNITY TO MEET WITH MANAGEMENT. Management of CorNova, and
management of each of the Participants each acknowledge that it has had an
opportunity

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to meet with and ask questions of the other' as management concerning the
business and financial condition of the other, and the terms and conditions of
this transaction as well as to obtain such information as deemed necessary to be
requested. Any questions or concerns raised concerning the transaction or the
other companies have been answered to the satisfaction of inquiring party.

         (f) RISK OF LOSS; EXPERIENCE. CorNova and each of the Participants
respective decision to engage in the Exchange is based upon its own independent
evaluation of the other. EACH PARTY HERETO RECOGNIZES THAT THE EXCHANGE IS
SPECULATIVE. The parties have carefully reviewed and understands the various
risks of the Exchange, and CorNova and each of the Participants can afford to
bear the risks of engaging in the Exchange; including the risk of losing their
respective entire investment, and the risk that the Securities shall be illiquid
for an indefinite period of time. CorNova and each of the Participants represent
for itself that it has the business and financial experience necessary to
evaluate the investment in the risks thereto.

         (g) RESTRICTIVE LEGEND. The Participants and CorNova acknowledge and
agree that the certificates representing the Securities to be acquired pursuant
to this Agreement will be imprinted with a restrictive legend substantially as
follows:

         THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR UNDER ANY
         APPLICABLE STATE SECURITIES LAWS AND ARE "RESTRICTED SECURITIES" AS
         THAT TERM IS DEFINED IN RULE 144 UNDER THE ACT. NEITHER THE SHARES NOR
         ANY INTEREST THEREIN MAY BE OFFERED FOR SALE, SOLD, TRANSFERRED,
         PLEDGED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE
         REGISTRATION STATEMENT UNDER THE ACT AND SUCH STATE SECURITIES LAWS OR
         AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT AND SUCH LAWS WHICH, IN
         THE OPINION OF COUNSEL FOR THE HOLDER, WHICH COUNSEL AND OPINION ARE
         REASONABLY SATISFACTORY TO THE COUNSEL FOR THIS CORPORATION, IS
         AVAILABLE.

The Participants and CorNova understand and agree that appropriate stop transfer
notations will be placed in the records of the issuer and with its respective
transfer agent, if any, in respect of the Securities which are to be issued
pursuant to this Agreement.

7.2 NO TRADING ON INSIDE INFORMATION. CorNova and the Participants are hereby
advised as follows:

The Participants are two publicly traded companies (collectively "P-T-Cs"). The
use of material nonpublic information in securities transactions (referred to as
"INSIDER TRADING") or the communication of such information to others who use it
in securities trading (referred to as "TIPPING") violates the United States
federal securities laws. Such violations may result in harsh consequences for
the individuals, entities or persons

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involved, including exposure to investigations by the U.S. Securities and
Exchange Commission ("SEC"), criminal and civil prosecution, disgorgement of any
profits realized or losses avoided (under certain laws and rules the calculation
of profits realized and losses avoided could exceed the actual amounts realized
or avoided) through the use of the nonpublic information and penalties based
upon such profits or losses.

The negotiations leading up to, and the signing of this Agreement, the Series A
Financing and the Closing contemplated hereunder, may constitute material
nonpublic information. Accordingly, each person who reads this Agreement may be
prohibited by law from trading in the securities of the P-T-Cs or directly or
indirectly disclosing such information to any other person(s) so that they may
trade in the securities of the P-T-Cs, until two (2) full business days after
the respective P-T-Cs have made adequate public disclosure through a press
release or filed a report on Form 8-K with the SEC.

It is difficult to describe what constitutes "material" information, but each
person who reads this Agreement should assume that any information, positive or
negative, which MIGHT be of significance to an investor determining whether to
purchase, sell or hold the P-T-Cs' securities, would be material.

7.3 NO DISCLOSURE UNTIL CLOSING OF SERIES A FINANCING. Until the minimum closing
of the Series A Financing has been consummated or terminated, without the prior
express written approval of all of the parties hereto, neither CorNova nor
either of the Participants shall make any public announcement with respect to
the Exchange or the Technology License, or any relationship between the
Participants and CorNova. Notwithstanding however, that the Participants shall
not be prohibited from making public announcements or filings that are required
under any law or pursuant to the rules and regulations promulgated by the
Commission or the American Stock Exchange to which the Participants are subject.
None of the parties hereto shall be prohibited from making any disclosures with
respect to the transactions and matters contemplated herein under a subpoena or
court order of competent jurisdiction. Provided, however, that the party
required to make such disclosure, announcement or filing shall immediately
notify the other parties hereto of such pending disclosure to provide them with
an opportunity to object and intervene through appropriate legal process.

                  ARTICLE VIII. LICENSE OF TECHNOLOGY & VENTURE

8.1 LICENSE OF TECHNOLOGY. Simultaneous with the issuance and exchange of the
Investment Shares, as set forth in Article III and the Exchange as set forth in
Article V, Cardiotech shall grant, convey and provide ("TECHNOLOGY LICENSE") to
CorNova an exclusive license, subject to customary terms and conditions to be
set forth in a separate license agreement (the "LICENSE"), for the technology
consisting of Chronoflex DES polymer or any poly (carbonate) urethane containing
derivative thereof for use on drug-eluting stents (collectively the
"TECHNOLOGY").

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8.2 NO COLLABORATION. Upon execution of this Agreement and through the term of
the License, Cardiotech shall not: (a) collaborate on or participate in any
Technology research with other parties; or (b) share, sell, transfer or
otherwise provide any intellectual property with respect to Technology research
or products with other parties.

8.3 VENTURE. CorNova shall focus its resources on the development and marketing
of innovative interventional cardiology products. The initial target of CorNova
is the development of a next-generation drug-eluting stent. CorNova will direct
its resources to develop or acquire technology relating to stent design, CE
testing and drug coatings, including but not limited to Chronoflex DES polymer
or any polycarbonatepolyurethane and containing derivative thereof for use on
drug-eluting stents. Utilizing the combined capabilities of the Participants,
CorNova will seek to produce a novel coronary stent system whose design,
materials, and manufacturing will be specific for drug elution technology.

                            ARTICLE IX. MISCELLANEOUS

9.1 CLOSING. The closing of the Contributory Shares and the CorNova Shares, and
the subsequent completion of the Exchange of the Investment Shares and the
Technology License, provided for herein (individually or collectively the
"CLOSING") shall occur the offices of one of the Participants, or at such place
and upon such date as CorNova and the Participants may mutually agree.

9.2 FEES AND EXPENSES. Each party hereto shall pay its own attorneys fees and
its own out-of-pocket expenses incurred prior to and in connection with the
transactions contemplated hereby. In addition, CorNova shall pay the reasonable
attorneys fees of the Participants' counsel up to an aggregate maximum of twenty
thousand dollars ($20,000) in legal fees including out-of-pocket expenses for
their review and services in connection with the Series A Financing. CorNova
shall, without incurring any further expense, have a right to review or audit
the legal fees and services provided thereunder, and the right to review work
product subject to redaction.

9.3 MODIFICATION, TERMINATION OR WAIVER. This Agreement may be amended,
modified, superseded or terminated, and any of the terms, covenants,
representations, warranties or conditions hereof may be waived, but only by a
written instrument executed by the party waiving compliance. The failure of any
party at any time or times to require performance of any provision hereof shall
in no manner affect the right of such party at a later time to enforce the same.

                                       2
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CorNova, Inc.
Exchange & Venture Agreement
Page 15

9.4 NOTICES. Any notice requests, demands and other communications required or
which may be given hereunder shall be in writing and shall be deemed to have
been duly given if delivered either personally or by either U.S. Mail certified
or registered mail, postage prepaid, or by overnight delivery service with all
delivery charges prepaid, AND fax if available, addressed to the parties at
their respective addresses set forth or referred to below:

IF TO CORNOVA, TO:                                WITH COPIES, TO:

CORNOVA, INC.                                     KENNETH B. LERMAN, P.C.
274 Ash Street                                    651 Day Hill Road
Hopkinton, MA 01748                               Windsor, Connecticut 06095
Attention: S. Eric Ryan, M.D.                     Attention: Kenneth B. Lerman,
           Chairman                                          Esquire
Fax: (508) 435-3866                               Fax: (860) 285-0139

IF TO CARDIOTECH, TO:                             IF TO CARDIOTECH AND/OR
                                                  IMPLANT, WITH COPIES, TO:

CARDIOTECH INTERNATIONAL, INC.
78E Olympia Avenue                                Attorneys at Law
Woburn, Massachusetts 01801                       Ellenoff Grossman & Schole LLP
                                                  370 Lexington Avenue
                                                  New York, New York 10017
Attention: Michael Szycher, Ph.D.,                Attention: Barry I. Grossman
           Chairman & CEO
Fax: (781) 937-4218                               Fax: (212) 370-7889

IF TO IMPLANT, TO:

IMPLANT SCIENCES, INC.
107 Audubon Road #5
Wakefield, Massachusetts 01880
Attention: Anthony Armini, Ph.D.
           President & CEO
Fax: (781) 246-1167

If mailed, delivery shall be deemed five (5) days after the date of mailing; if
overnight delivery, delivery shall be deemed the next business day provided such
services were selected and paid for. The parties may change the persons and
addresses to which the notices or other communications are to be sent to it by
giving written notice of any such change in the manner provided herein for
giving notice.

9.5 BINDING EFFECT AND ASSIGNMENT. This Agreement shall be binding upon and
inure to the benefit of the successors and assigns of the parties hereto. No
assignment of any rights or delegation of any obligations provided for herein
may be made by any party without the express written consent of the other party.

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CorNova, Inc.
Exchange & Venture Agreement
Page 16

9.6 ENTIRE AGREEMENT. This Agreement, along with the other agreements referenced
herein, contain the entire Agreement between the parties with respect to the
subject matter hereof. In the event of a conflict or inconsistency, this
Agreement is the definitive and governing agreement with respect to the subject
matter hereof.

9.7 CALENDAR DAYS. All references to "days" in this agreement with respect to
the amount of time allocated for notices, performance or other periods shall
mean calendar days, unless otherwise specified.

9.8 EXHIBITS. All Exhibits annexed hereto and the documents and instruments
referred to herein or required to be delivered simultaneously herewith or at the
Closing are expressly made a part of this Agreement as fully as though
completely set forth herein, and all references to this Agreement herein or in
any such Exhibits, documents or instruments shall be deemed to refer to and
include all such Exhibits, documents and instruments. Any execution of this
Agreement is subject to the receipt of current and complete exhibits.

9.9 GOVERNING LAW. This Agreement shall be governed by, and construed in
accordance with the laws of the State of Delaware.

9.10 CONSENT TO JURISDICTION. The parties here to consent to jurisdiction of the
Courts of the State of Massachusetts and to the U.S. District Court in the
District of Massachusetts.

9.11 COUNTERPARTS. This Agreement may be executed in counterparts, each of which
shall be deemed to be an original, but which together shall constitute one and
the same instrument.

9.12 SECTION HEADINGS. The section headings contained in this Agreement are
inserted for convenience of reference only and shall not affect the meaning or
interpretation of this Agreement.

[THE REMAINDER OF THIS PAGE HAS BEEN LEFT INTENTIONALLY BLANK. THE SIGNATURE
PAGE FOLLOWS.]

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CorNova, Inc.
Exchange & Venture Agreement
Page 17

         WITNESS the execution of this Agreement as of the date first above
written.

CORNOVA, INC.

BY:__________________
   S. Eric Ryan
   Chairman

CARDIOTECH INTERNATIONAL, INC.                      IMPLANT SCIENCES, INC.

BY:_____________________                            BY:____________________
   Michael Szycher                                     Anthony Armini
   Chairman & CEO                                      President & CEO

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