Document:

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                                                                    EXHIBIT 10.8

                           INDEMNITY ESCROW AGREEMENT

        This INDEMNITY ESCROW AGREEMENT (this "Agreement"), dated as of April
28, 2000, is by and among Discovery Partners International, Inc., a California
corporation ("DPII"), Axys Pharmaceuticals, Inc., a Delaware corporation
("Axys"), and the institution named on the signature page under "Escrow Agent,"
as Escrow Agent ("Escrow Agent"). Unless otherwise defined herein, all
capitalized terms used in this Agreement shall have the meaning ascribed to such
terms in the Agreement and Plan of Merger dated as of April 11, 2000 (the
"Merger Agreement"), by and among DPII, DPII Newco, LLC, a Delaware limited
liability company and a wholly-owned subsidiary of DPII, Axys Advanced
Technologies, Inc., a Delaware corporation ("AAT") and Axys.

        Accordingly, the parties hereto agree as follows:

        1. Appointment and Acceptance. Axys and DPII hereby appoint Escrow Agent
as escrow agent for the purposes and upon the terms and conditions hereinafter
set forth. Escrow Agent hereby accepts such appointment and agrees to act as
escrow agent hereunder and to hold, invest and dispose of any funds received by
it hereunder in accordance with the terms and conditions hereinafter set forth.

        2. Deposit of Escrowed Consideration. On the date hereof, DPII delivered
to Escrow Agent for deposit in escrow pursuant to the provisions hereof a share
certificate (the "Share Certificate") for *** shares of DPII Common Stock, made
out in favor of Axys (the "Escrowed Consideration").

        3. Purpose of Agreement. DPII and Axys represent that this Agreement has
been executed and the deposit of the Escrowed Consideration hereunder has been
made pursuant to the Merger Agreement for the purpose of providing a fund for
the payment of the first amounts owed (if any) to DPII in connection with the
Merger Agreement ("Covered Claims").

        4. Delivery of Escrowed Consideration.

                (a) Because of the lump nature of the share certificate which
constitutes the initial Escrowed Consideration, the parties agree that in any
case where Escrowed Consideration is to be delivered to DPII hereunder, such
delivery shall be accomplished by delivery of the Share Certificate to DPII;
DPII shall promptly calculate, based on the "Fair Market Value" per share (as
defined below), the number of shares to be cancelled in respect of such
delivery, and shall promptly return to Escrow Agent, for escrow, a new share
certificate (which shall hereafter be considered the "Share Certificate")
representing a number of shares of DPII Common Stock reflecting the reduction
for the number of cancelled shares. Axys hereby authorizes the cancellation of
shares to the extent and in the manner expressly authorized by this Agreement.
For the purposes of this Agreement, the "Fair Market Value" per share of DPII
Common Stock shall be determined as follows:

*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission

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                        (i) If traded on a securities exchange or through
NASDAQ-NMS, the Fair Market Value shall be deemed to be the average of the
closing price of such share on such exchange over the twenty (20) day period
ending three (3) days prior to the date on which the Escrow Agent is obligated
to deliver any portion of the Escrowed Consideration hereunder; and

                        (ii) If there is no active public market, the Fair
Market Value shall be deemed to be the per share price at which the Company sold
shares of its capital stock in its most recent equity financing negotiated on an
arms'-length basis.

                (b) If at any time prior to the first anniversary of the date
hereof DPII shall claim that it is entitled to payment of all or a portion of
the Escrowed Consideration as a result of any Covered Claim, DPII shall give
notice of such Covered Claim (the "Notice of Covered Claim") to the Escrow
Agent. The Notice of Covered Claim shall describe with reasonable specificity
the event or circumstance giving rise to the Covered Claim and specifying the
amount of the Escrowed Consideration which should be released to satisfy such
Covered Claims. Upon Escrow Agent's receipt of a Notice of Covered Claim from
DPII, Escrow Agent shall promptly deliver a copy thereof to Axys. Within fifteen
(15) business days after delivery by Escrow Agent of a copy of such Notice of
Covered Claim to Axys, Axys may deliver to Escrow Agent a notice (the "Notice of
Dispute") disputing the request for payment of Escrowed Consideration stated in
the Notice of Covered Claim. The Notice of Dispute shall specify the amount
being disputed (the "Disputed Funds"), describing with reasonable specificity
the reasons for such dispute. If Escrow Agent has not received a Notice of
Dispute prior to the expiration of the 15-day period referred to above, then
upon expiration of such 15-day period, the Escrow Agent shall pay to DPII,
within three business days, as provided in Section 4(a) above, the full amount
of the Escrowed Consideration requested in the Notice of Covered Claim. If
Escrow Agent has received a Notice of Dispute which disputes in part the request
for payment of Escrowed Consideration stated in the Notice of Covered Claim,
then Escrow Agent shall pay to DPII, within three business days, as provided in
Section 4(a) above, the amount of Escrowed Consideration requested in the Notice
of Covered Claim which is not Disputed Funds.

                (c) If Escrow Agent receives a Notice of Dispute from Axys,
Escrow Agent shall promptly deliver a copy of the Notice of Dispute to DPII, and
shall not deliver the Disputed Funds (i.e., the Share Certificate in respect of
the Disputed Funds) to DPII until Escrow Agent shall have received one of the
following:

                        i. A certified copy of an order, decree or judgment
issued or rendered by a court of competent jurisdiction, which order, decree or
judgment shall be accompanied by a legal opinion of counsel to DPII that such
judgment has been finally affirmed on appeal or which by lapse of time or
otherwise is no longer subject to appeal (a "Final Decision") with respect to
the Notice of Covered Claim which is the subject of the Notice of Dispute; or

                        ii. A joint written direction executed by DPII and Axys
directing the distribution of the relevant portion of the Escrowed
Consideration.

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Upon receipt of either (i) or (ii) above, Escrow Agent shall deliver the
relevant portion of the Escrowed Consideration, within three business days, by
delivery of the Share Certificate to DPII in accordance with the terms of such
Final Decision or joint direction, as the case may be.

                (d) On the first anniversary of the date hereof, any Escrowed
Consideration which is not Disputed Funds or the subject of an unresolved Notice
of Covered Claim shall be paid to Axys. To effect this, Escrow Agent shall
deliver the Share Certificate to DPII, and DPII shall issue and deliver to Axys
as provided in Section 6(b) below a share certificate for the shares which are
not Disputed Funds and are not the subject of an unresolved Notice of Covered
Claim; and DPII shall issue and deliver to the Escrow Agent, for escrow, a new
Share Certificate in Axys' name for the remainder, if any, of the shares.

        5. Investment of Escrowed Consideration. Escrow Agent shall invest any
cash dividends on or other cash processed of the Escrowed Consideration, from
time to time, in investments jointly designated in writing by DPII and Axys or,
in the absence of such designation, in a money-market fund. The investments of
Escrowed Consideration may be executed by Escrow Agent's own investment
department. The interest and investment proceeds of all investments made
hereunder shall be retained as part of the escrow as Escrowed Consideration and
distributed as provided herein with respect to the Escrowed Consideration.
Escrow Agent shall deliver monthly statements to DPII and Axys in accordance
with Escrow Agent's regular practice; the parties hereby agree that, except for
the foregoing, Escrow Agent shall have no obligations to monitor, or advise the
parties with respect to, such investments.

        6. Termination of Escrow.

                (a) Except as set forth in Section 6(b), this Agreement shall
terminate upon the earliest of (i) the receipt by Escrow Agent of written notice
of termination executed by both DPII and Axys directing the distribution of all
property then held by Escrow Agent under and pursuant to the Agreement, (ii)
when all Escrowed Consideration (and all interest and investments in which any
of the Escrowed Consideration shall have been invested) shall have been
distributed by Escrow Agent in accordance with the terms of this Agreement; or
(iii) the first anniversary of the Closing Date.

                (b) Notwithstanding Section 6(a), in the event that upon the
first anniversary of the Closing Date, there remains in the escrow, any portion
of the Escrowed Consideration which is Disputed Funds or the subject of an
unresolved Notice of Covered Claim, then this Agreement shall not terminate on
such first anniversary with respect to such funds and shall continue until the
resolution of the dispute pursuant to Section 4(b). Any Escrowed Consideration
which is not Disputed Funds or subject to an unresolved Notice of Covered Claim
shall be delivered to Axys within three business days of the termination of the
Agreement. To effect this, Escrow Agent shall deliver the Share Certificate to
DPII, and DPII shall issue and deliver to Axys a share certificate for the
shares which are not Disputed Funds and are not the subject of an unresolved
Notice of Covered Claim; and DPII shall issue and deliver to the Escrow Agent,
for escrow, a new Share Certificate in Axys' name for the remainder of the
shares.

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                        (c) Escrow Agent is authorized to liquidate the
securities (other than DPII shares) held hereunder to the extent necessary to
distribute the Escrowed Consideration as provided herein and shall have no
liability for any loss arising out of any such liquidation.

        7. Notices. All notices, requests and other communications hereunder
must be in writing and will be deemed to have been duly given only if delivered
personally or by facsimile transmission with answer back confirmation or mailed
(first class, postage prepaid) or by overnight courier to the parties at the
addresses or facsimile numbers set forth below such party's signature to this
Agreement. All such notices, requests and other communications will (i) if
delivered personally or by overnight courier to the address as provided in this
Section, be deemed given upon delivery, (ii) if delivered by facsimile
transmission to the facsimile number as provided in this Section, be deemed
given upon sending, and (iii) if delivered by mail in the manner described above
to the address as provided in this Section, be deemed given two business days
after mailing (in each case regardless of whether such notice, request or other
communication is received by any other person to whom a copy of such notice,
request or other communication is to be delivered pursuant to this Section). Any
party from time to time may change its address, facsimile number or other
information for the purpose of notices to that party by giving notice specifying
such change to the other parties hereto.

        8. Escrow Agent's Liability. Escrow Agent undertakes to perform such
duties and only such duties as are specifically set forth in this Agreement, and
no implied covenants or obligations shall be read into this Agreement against
Escrow Agent. In the absence of bad faith, gross negligence or willful
misconduct on its part, Escrow Agent may conclusively rely, as to the truth of
the statements and the correctness of the opinions expressed therein, upon
certificates or opinions furnished to Escrow Agent. Escrow Agent may act upon
any instrument, certificate, opinion or other writing believed by it in good
faith and without gross negligence to be genuine, and shall not be liable in
connection with the performance by it of its duties pursuant to the provisions
of the Agreement, except for its own bad faith, gross negligence or willful
misconduct. Escrow Agent may consult with counsel of its own choice and shall
have full and complete authorization and protection for any action taken,
suffered or omitted by it hereunder in good faith and in accordance with the
opinion of such counsel. Escrow Agent may execute powers hereunder or perform
any duties hereunder either directly or by or through agents or attorneys.

        9. Indemnification of Escrow Agent. Axys and DPII shall jointly and
severally indemnify and hold harmless Escrow Agent (and any successor Escrow
Agent) for any loss, liability or expense incurred without gross negligence,
willful misconduct or bad faith on the part of Escrow Agent, arising out of or
in connection with its entering into the Agreement, carrying out its duties
hereunder and accepting the Escrowed Consideration, including the costs and
expenses of defending itself against any claim of liability in connection with
the exercise or performance of any of its powers or duties hereunder (including
reasonable fees, expenses and disbursements of its counsel). Axys and DPII agree
to promptly reimburse the other party for any payments to Escrow Agent under
this Section 9 as necessary in order to ensure that all such payments are shared
equally by Axys and DPII.

        10. Escrow Agent to Follow Instructions of DPII and Axys.
Notwithstanding any provision contained herein to the contrary, Escrow Agent
shall at any time and from time to time

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take such action hereunder with respect to the Escrowed Consideration (and the
investments in which any of the Escrowed Consideration shall have been invested)
as shall be directed in writing by both DPII and Axys.

        11. Resignation of Escrow Agent. Escrow Agent, or any successor, may
resign at any time upon giving written notice, thirty (30) days before such
resignation shall take effect, to DPII and Axys. In the event Escrow Agent shall
resign or be unable to serve, it shall be succeeded by such bank or trust
company as DPII and Axys shall appoint, or if no appointment is made, by a bank
or trust company appointed by a court of competent jurisdiction. In the absence
of a successor so appointed by DPII and Axys, Escrow Agent may petition such a
court to appoint a successor escrow agent. The resigning escrow agent shall
transfer to its successor all money, securities and investments then held
subject to this escrow and all pending notices, instructions and directions then
in its possession, and shall thereupon be discharged, and the successor shall
thereupon succeed to all the rights, powers and duties and shall assume all of
the obligations of the resigning escrow agent.

        12. Escrow Agent's Fees.

                (a) Escrow Agent shall be entitled to a fee for services
rendered according to the fee schedule attached hereto. One half of such fees
shall be paid by Axys and one-half of such fees shall be paid by DPII.

                (b) In case Escrow Agent becomes involved in litigation on
account of the property deposited hereunder or this Agreement, it shall have the
right to retain counsel. One half of any and all costs, attorneys' fees,
charges, disbursements, and expenses in connection with such litigation shall be
paid by Axys and one-half of such fees shall be paid by DPII.

                (c) Axys and DPII agree to promptly reimburse the other party
for any payments to Escrow Agent under this Section 12 in order to ensure that
all such payments are shared equally by Axys and DPII.

        13. Escrow Agent's Reaction to Disputes.

                (a) In case the Escrowed Consideration shall be attached,
garnished, or levied upon any court order, or the delivery thereof shall be
stayed or enjoined by an order of court, or any order, judgment or decree shall
be made or entered by any court affecting the property deposited under this
Agreement, or any part thereof, Escrow Agent is hereby expressly authorized in
its sole direction, to obey and comply with all writs, orders or decrees so
entered or issued, which it is advised by legal counsel of its own choosing is
binding upon it, whether with or without jurisdiction, and in case Escrow Agent
obeys or complies with any such writ, order or decree it shall not be liable to
any of the parties hereto or to any other person, firm or corporation, by reason
of such compliance notwithstanding such writ, order or decree is subsequently
reversed, modified, annulled, set aside or vacated.

                (b) In case conflicting demands are made upon it for any
situation not addressed in this Agreement, Escrow Agent may withhold performance
of this escrow with respect to matters related to such conflicting demands until
such time as said conflicting

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demands shall have been withdrawn or the rights of the respective parties shall
have been settled by court adjudication, arbitration, joint order or otherwise.

        14. Assignment. The obligations imposed and the rights conferred by this
Escrow Agreement shall be binding upon and inure to the benefit of the
respective successors and assigns of the parties hereto.

        15. Governing Law, Consent to Jurisdiction and Forum Selection. This
Indemnity Escrow Agreement shall be governed by and construed in accordance with
the laws of the State of California, without giving effect to principles of
conflicts of law. The parties hereto agree that all actions or proceedings
arising in connection with this Agreement (as to proceedings initiated by Axys)
shall be initiated and tried exclusively in the State and Federal courts located
in the County of San Diego, State of California. The parties hereto agree that
all actions or proceedings arising in connection with this Agreement (as to
proceedings initiated by DPII or Escrow Agent) shall be initiated and tried
exclusively in the State and Federal courts located in the County of San
Francisco, State of California. The aforementioned choice of venue is intended
by the parties to be mandatory and not permissive in nature, thereby precluding
the possibility of litigation between the parties with respect to or arising out
of this Agreement in any jurisdiction other than that specified in this Section
15. Each party hereby waives any right it may have to assert the doctrine of
forum non conveniens or similar doctrine or to object to venue with respect to
any proceeding brought in accordance with this paragraph, and stipulates that
the State and Federal courts located in the County of San Diego, State of
California (as to proceedings initiated by Axys) or in the County of San
Francisco, State of California (as to proceedings initiated by DPII or Escrow
Agent) shall have in personam jurisdiction and venue over each of them for the
purposes of litigating any dispute, controversy or proceeding arising out of or
related to this Agreement. Each party hereby authorizes and accepts service of
process sufficient for personal jurisdiction in any action against it as
contemplated by this Section 15 by registered or certified mail, return receipt
requested, postage prepaid, to its address for the giving of notices as set
forth in this Agreement, or in the manner set forth in Section 7 of this
Agreement for the giving of notice. Any final judgment rendered against a party
in any action or proceeding shall be conclusive as to the subject of such final
judgment and may be enforced in other jurisdictions in any manner provided by
law.

        16. Entire Agreement. This Agreement, together with the Merger
Agreement, with respect to which the Escrow Agent is not a party (including the
schedules and exhibits thereto and the other agreements contemplated thereby),
contains the entire agreement between the parties hereto with respect to the
transactions contemplated herein.

        17. Amendment. This Agreement cannot be terminated, altered or amended
except pursuant to an instrument in writing signed by DPII, Axys and Escrow
Agent.

        18. Merger, Conversion, Consolidation or Succession to Business.

                (a) Any corporation into which Escrow Agent may be merged or
converted or with which it may be consolidated, or any corporation resulting
from any merger, conversion or consolidation to which Escrow Agent shall be a
party, or any corporation succeeding to all or substantially all of the
corporate trust business of Escrow Agent, shall be the successor of

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Escrow Agent hereunder without the execution or filing of any paper or any
further act on the part of any of the parties hereto.

                (b) Any corporation into which DPII or Axys may be merged or
converted or with which it may be consolidated, or any corporation resulting
from any merger, conversion or consolidation to which DPII or Axys shall be a
party, shall be the successor of DPII or Axys hereunder without the execution or
filing of any paper or any further act on the part of any of the parties hereto.

        19. Enforceability. If any provision hereof shall be held invalid or
unenforceable, such invalidity or unenforceability shall attach only to such
provision and shall not in any manner affect or render invalid or unenforceable
any other provision of this Indemnity Escrow Agreement, and the Agreement shall
be carried out as if any such invalid or unenforceable provision were not
contained herein.

        20. Distributions. Distributions of the Escrowed Consideration to DPII
pursuant to this Agreement shall be deemed to be reductions of the merger
consideration paid under the Merger Agreement.

        21. Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be deemed an original and all of which
together shall constitute one and the same instrument.

        [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

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        IN WITNESS WHEREOF, the parties hereto have caused this Indemnity Escrow
Agreement to be signed as of the date first above written.

                                         AXYS PHARMACEUTICALS, INC.,
                                         a Delaware corporation

                                         By: /s/ William T. Newell
                                            ------------------------------------
                                            Name:  William T. Newell
                                            Title: Senior Vice President

                               Address:  180 Kimball Way
                                         South San Francisco, CA 94080
                                         Attn: Chief Executive Officer
                                           Fax: (650) 829-1067

                                         DISCOVERY PARTNERS INTERNATIONAL, INC.,
                                         a California corporation

                                         By: /s/ Riccardo Pigliucci
                                            ------------------------------------
                                            Name:  Ricardo Pigliucci
                                            Title: Chairman and CEO

                               Address:  9640 Towne Centre Drive
                                         San Diego, CA 92121
                                         Attn: Chief Executive Officer
                                           Fax: (858) 455-8088

                          ESCROW AGENT:  U.S. TRUST COMPANY NATIONAL ASSOCIATION

                                         By: /s/ M. Deborah Gibbons
                                            ------------------------------------
                                            Name:  M. Deborah Gibbons
                                            Title: Vice President

                               Address:  515 South Flower, Suite 2700
                                         Los Angeles, CA 90071

                 [SIGNATURE PAGE TO INDEMNITY ESCROW AGREEMENT]

                                       8<PAGE>   1

                                                                   EXHIBIT 10.10

                           FIRST AMENDMENT TO SUBLEASE

      This FIRST AMENDMENT TO LEASE (this "Amendment") is dated as of this 28th
day of April, 2000, by and between AXYS PHARMACEUTICALS, INC., a Delaware
corporation ("Sublandlord"), and AXYS ADVANCED TECHNOLOGIES, INC., a Delaware
corporation ("Subtenant").

                                    RECITALS

      A. Sublandlord and Subtenant entered into a Sublease dated January 1, 2000
(the "Sublease"), for premises within a building with a street address of 385
Oyster Point Blvd., South San Francisco, California, and more particularly
described in the Sublease;

      B. Sublandlord and Subtenant now desire to amend the Sublease on the terms
and conditions set forth herein. Capitalized terms used in this Amendment and
not otherwise defined shall have the meanings assigned to them in the Sublease.

                                    AGREEMENT

      NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Sublandlord and Subtenant hereby
agree as follows:

(a) LEASE AMENDMENT. Commencing on April 28, 2000, the Sublease is amended as
follows:

            (a) SUBLEASED PREMISES: The last sentence of Section 1.1(a) is
hereby deleted in its entirety.

            (b) ACCEPTANCE OF SUBLEASED PREMISES: The following words are hereby
inserted at the beginning of the third sentence of Section 2.2: "Except as
otherwise set forth in that certain Agreement and Plan of Merger by and among
Discovery Partners International, Inc., a California corporation, DPII Newco,
LLC, a Delaware limited liability company and a wholly-owned subsidiary of
Discovery Partners International, Inc., Axys Advanced Technologies, Inc., a
Delaware corporation, and Axys Pharmaceuticals, Inc., a Delaware corporation
dated as of April 11, 2000 (the "Merger Agreement"),".

            (c) INCORPORATION BY REFERENCE; ASSUMPTION. The first sentence of
Section 3.1 is hereby deleted and replaced, in its entirety, with the following:
"All of the Sections of the Lease are incorporated into this Sublease as if
fully set forth in this Sublease except for the following: 1, 2.1, 3.1, 3.3,
4.1, 5, 7, 13.4, 38, 29, First Addendum Sections 1, 13, and 20."

            (d) COMMON AREA DEFINITION: The third sentence of Section 3.8(a)
is hereby deleted in its entirety and replaced with the following: "Subject to
the prior written consent of Landlord and Sublandlord and the terms and
conditions of the Lease, Subtenant may, at Subtenant's sole cost and expense, be
allowed to install, maintain and operate a small communications antenna on the
roof of the Building and other rooftop communications equipment which are
permitted by the Lease, at location(s) and in accordance with plans approved by
Landlord and Sublandlord; provided that Subtenant shall be obligated to pay for
any additional cost incurred by Sublandlord arising from such work
notwithstanding Landlord's and Sublandlord's approval thereof, including but not
limited to, any violation of the roof warranty for the Building."

            (e) BASE RENT:  The following sentence is hereby added to the end
of Section 4.1: "Should Sublandlord fail to make any monetary payments to
Landlord that constitute a default under the Lease ("Default

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Payments"), Subtenant may make such Default Payment(s) and offset such paid
Default Payment against Rent, as defined herein."

      (f) USE: The words "and Sublandlord's" is hereby inserted after the first
appearance of the word "Subtenant" in Section 6.1(b).

      (g) UTILITY INSTALLATIONS, TRADE FIXTURES, ALTERATIONS: The last sentence
of Section 7.3(b) is hereby deleted in its entirety.

      (h) INDEMNITY: The following is hereby added to the lease as new section
8.6(a): "Sublandlord will indemnify, defend (by counsel acceptable to Subtenant
in its reasonable discretion), protect and hold Subtenant harmless from and
against any and all liabilities, claims, demands, losses, damages, costs and
expenses (including attorneys' fees) arising out of or relating to (i)
Sublandlord's and its agents', employees' and invitees' use of the Subleased
Premises and any negligent acts or willful misconduct in their use or occupancy
of the Building other than the Subleased Premises, (ii) Sublandlord's breach or
default under this Sublease, or (iii) Hazardous Materials brought into the
Building by or for Sublandlord, or any such Hazardous Materials shipped for
storage, treatment or disposal from the Building by or for Sublandlord. The
foregoing shall include, but not be limited to, the defense or pursuit of any
claim or any act on or proceeding involved therein, and whether or not (in the
case of claims made against Subtenant) litigated and/or reduced to judgment. In
case any action or proceeding is brought against Subtenant by reason of any of
the foregoing matters, Sublandlord, upon notice from Subtenant, shall defend the
same at Sublandlord's expense by counsel reasonably satisfactory to Subtenant
and Subtenant shall cooperate with Sublandlord in such defense. Subtenant need
not have first paid any such claim in order to be so indemnified.

      (i) ASSIGNMENT AND SUBLETTING: The following is hereby inserted at the end
of Section 9: "and; (iv) any other reasonable out-of-pocket cost incurred as a
result of the assignment or subletting."

      (j) SUBTENANTS'S SERVICES TO SUBLANDLORD: The second sentence of Section
10(a) is hereby deleted in its entirety and replaced with the following: "Either
Subtenant or Sublandlord may terminate such services within ninety (90) days
prior written notice by the party electing to receive the services."

      (k) CONFIDENTIALITY: Section 17 of the Sublease is hereby deleted in its
entirety and replaced with the following: "Unless otherwise agreed to in writing
by Sublandlord and Subtenant, each party shall keep confidential all terms,
conditions, documents, and other information provided to, or generated by the
other party, relating to this Sublease in accordance with the terms and
conditions of the Merger Agreement."

      (l) ATTORNEYS FEES: The following is hereby added to the end of Section
20.1: "The prevailing party shall be determined by the trier of fact based upon
an assessment of which party's major arguments or positions taken in the
proceedings could fairly be said to have prevailed over the other party's major
arguments or positions on major disputed issues ("PREVAILING PARTY"). The
Prevailing Party, for the purpose of any settlement, dismissal or summary
judgment, shall be the party receiving substantially the relief requested. For
the purposes of this section, attorneys' fees shall include, without limitation,
fees incurred in the following: (1) post-judgment motions; (2) contempt
proceedings; (3) garnishment, levy, and debtor and third party examinations; (4)
discovery; (5) bankruptcy litigation; and (6) enforcement of the indemnity
provisions contained herein. This Section is intended to be expressly severable
from the other provisions of this Agreement, is intended to survive any judgment
and is not to be deemed merged into the judgment.

      (m) WAIVER OF JURY TRIAL AND RIGHT TO ARBITRATE: The following is hereby
added to the Sublease as new section 21: "SUBLANDLORD AND SUBTENANT EACH
ACKNOWLEDGES THAT IT IS AWARE OF AND HAS HAD THE ADVICE OF COUNSEL OF ITS CHOICE
WITH RESPECT TO ITS RIGHTS TO TRIAL BY JURY, AND EACH PARTY DOES HEREBY
EXPRESSLY AND KNOWINGLY WAIVE AND RELEASE ALL SUCH RIGHTS TO TRIAL BY JURY IN
ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY EITHER PARTY HERETO AGAINST
THE OTHER (AND/OR AGAINST ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS, OR
SUBSIDIARY OR AFFILIATED ENTITIES) ON

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ANY MATTERS WHATSOEVER ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE SUBLEASE
AS AMENDED, SUBTENANT'S USE OR OCCUPANCY OF THE PREMISES, AND/OR ANY CLAIM OF
INJURY OR DAMAGE. SHOULD A DISPUTE ARISE BETWEEN THE PARTIES REGARDING ANY
MATTER DESCRIBED ABOVE, THEN EXCEPT WITH RESPECT TO ACTIONS FOR UNLAWFUL OR
FORCIBLE DETAINER EITHER PARTY MAY CAUSE THE DISPUTE TO BE SUBMITTED TO
JAMS/ENDISPUTE OR ITS SUCCESSOR ("JAMS") IN SAN FRANCISCO, CALIFORNIA, FOR
BINDING ARBITRATION BEFORE A SINGLE ARBITRATOR. HOWEVER, EACH PARTY RESERVES THE
RIGHT TO SEEK A PROVISIONAL REMEDY BY JUDICIAL ACTION. NO ARBITRATION ELECTION
BY EITHER PARTY PURSUANT TO THIS SUBSECTION SHALL BE EFFECTIVE IF MADE LATER
THAN THIRTY (30) DAYS FOLLOWING SERVICE OF A JUDICIAL SUMMONS AND COMPLAINT BY
OR UPON SUCH PARTY CONCERNING THE DISPUTE. THE ARBITRATION SHALL BE CONDUCTED IN
ACCORDANCE WITH THE RULES OF PRACTICE AND PROCEDURE OF JAMS AND OTHERWISE
PURSUANT TO THE CALIFORNIA ARBITRATION ACT (CODE OF CIVIL PROCEDURE SECTIONS
1280 ET SEQ.). NOTWITHSTANDING THE FOREGOING, THE ARBITRATOR IS SPECIFICALLY
DIRECTED TO LIMIT DISCOVERY TO THAT WHICH IS ESSENTIAL TO THE EFFECTIVE
PROSECUTION OR DEFENSE OF THE ACTION, AND IN NO EVENT SHALL SUCH DISCOVERY BY
EITHER PARTY INCLUDE MORE THAN ONE NON-EXPERT WITNESS DEPOSITION UNLESS BOTH
PARTIES OTHERWISE AGREE. THE ARBITRATOR SHALL APPORTION THE COSTS OF THE
ARBITRATION, TOGETHER WITH THE ATTORNEYS' FEES OF THE PARTIES, IN THE MANNER
DEEMED EQUITABLE BY THE ARBITRATOR, IT BEING THE INTENTION OF THE PARTIES THAT
THE PREVAILING PARTY ORDINARILY BE ENTITLED TO RECOVER ITS REASONABLE COSTS AND
FEES. JUDGMENT UPON ANY AWARD RENDERED BY THE ARBITRATOR MAY BE ENTERED BY ANY
COURT HAVING JURISDICTION.

As indicated by our initials below, we have read and understand the foregoing
and agree to submit disputes arising out of the matters subject to arbitration
pursuant to this Sublease to neutral, binding arbitration:

               Sublandlord:  WJN            Subtenant:    WJN
                             -------                    -----

(b) RATIFICATION. The Sublease, as amended by this Amendment, is hereby ratified
    by Sublandlord and Subtenant and Sublandlord and Subtenant hereby agree that
    the Sublease, as so amended, shall continue in full force and effect.

(c) MISCELLANEOUS. MISCELLANEOUS.

            (a) VOLUNTARY AGREEMENT. The parties have read this Amendment and on
the advice of counsel they have freely and voluntarily entered into this
Amendment.

            (b) ATTORNEY'S FEES. If either party commences an action against the
other party arising out of or in connection with this Amendment, the prevailing
party shall be entitled to recover from the losing party reasonable attorney's
fees and costs of suit.

            (c) SUCCESSORS. This Amendment shall be binding on and inure to the
benefit of the parties and their successors.

            (d) COUNTERPARTS. This Amendment may be signed in two or more
counterparts. When at least one such counterpart has been signed by each party,
this Amendment shall be deemed to have been fully executed, each counterpart
shall be deemed to be an original, and all counterparts shall be deemed to be
one and the same agreement.

                                       3
<PAGE>   4

        IN WITNESS WHEREOF, Sublandlord and Subtenant have executed this
Amendment as of the date first written above.

                             SUBLANDLORD:

                             AXYS PHARMACEUTICALS, INC., a Delaware corporation

                             By:  /s/ William J. Newell
                                 --------------------------------

                             Its: Senior Vice President
                                 --------------------------------

                             SUBTENANT:

                             AXYS ADVANCED TECHNOLOGIES, INC., a
                             Delaware corporation

                             By:/s/ William J. Newell
                                 --------------------------------

                             Its:Secretary
                                 --------------------------------

                                       4

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