Document:

<PAGE>
                                                                     Exhibit 4.5

                        WAIVER AND FIRST AMENDMENT dated as of February 7, 2000
                  (this "Waiver and Amendment"), to the Amended and Restated
                  Credit Agreement dated as of November 6, 1998 (the "Credit
                  Agreement"), among SCHEIN PHARMACEUTICAL, INC., a Delaware
                  corporation (the "Borrower"), the lenders party hereto (the
                  "Lenders") and THE CHASE MANHATTAN BANK, a New York banking
                  corporation, as administrative agent for the Lenders (in such
                  capacity, the "Administrative Agent"), as issuing bank and as
                  collateral agent.

            The Borrower has requested that the Lenders waive compliance with
certain covenants contained in the Credit Agreement, and the Lenders executing
this Waiver and Amendment are willing to waive compliance with such covenants on
the terms and conditions and for the period set forth below. Capitalized terms
used and not otherwise defined herein shall have the meanings assigned to them
in the Credit Agreement.

            In consideration of the premises and the agreements, provisions and
covenants herein contained, the parties hereto hereby agree, on the terms and
subject to the conditions set forth herein, as follows:

            SECTION 1. Waiver of Certain Covenants. (a) Subject to Section 5
below, the undersigned Lenders hereby waive compliance, at all times on or after
September 26, 1999, and on or prior to March 15, 2000, with the covenants
contained in (i) Section 6.14 of the Credit Agreement, but only so long as the
Leverage Ratio shall not at any time on or after September 26, 1999, have
exceeded 6.00 to 1.00; (ii) Section 6.17 of the Credit Agreement, but only so
long as the Fixed Charge Coverage Ratio shall not at any time on or after
September 26, 1999, have been less than 0.60 to 1.00; and (iii) Section 6.18 of
the Credit Agreement, but only so long as the Interest Expense Coverage Ratio
shall not at any time on or after September 26, 1999, have been less than 2.00
to 1.00. The waivers provided for in the preceding sentence will terminate on
the earlier of (x) 5:00 p.m., New York City time, on March 15, 2000, (y) any
date on which an Event of Default shall occur under the Credit Agreement (giving
effect to the waiver provided for in this Section) and (z) any date on which the
Borrower shall fail to perform any of its undertakings under this Waiver and
Amendment (the first to occur of the dates referred to in the preceding clauses
(x), (y) and (z) being called the "Termination Date").

            (b) Notwithstanding any other provision of this Waiver and
Amendment, on the Termination Date, the waiver set forth in the preceding
paragraph (a) shall terminate and cease to be of any force or effect, and the
Administrative Agent, the Collateral Agent and the Lenders shall have all rights
under the Loan Documents that would have been available to them had such waiver
never been granted.

            SECTION 2. Certain Amendments to Credit Agreement. (a) The
definition of "Applicable Percentage" in Section 1.01 of the Credit Agreement is
hereby amended by deleting clause (b) of the third sentence following the table
therein and inserting in its place the following:

            "(b) subject to clause (a) above, Category 6 from and including
February

<PAGE>
                                                                               2

            7, 2000, through the Termination Date (as defined in the Waiver and
            First Amendment dated as of February 7, 2000, to this Agreement").

            (b) The definition of "Net Income" in Section 1.01 of the Credit
Agreement is hereby amended by inserting at the end thereof the following new
sentence:

            "For any period including the fiscal quarter ended December 25,
            1999, Net Income shall be determined without giving effect to a
            non-cash impairment charge for Marsam Pharmaceutical, Inc. in a
            pre-tax amount not to exceed $63,000,000 to be recorded by the
            Borrower as of December 25, 1999."

            (c) The definition of "Net Worth" in Section 1.01 of the Credit
Agreement is hereby amended to read as follows:

                  "Net Worth" as of any date shall mean Stockholder's Equity as
            of such date plus the amount of any charge by the Borrower for
            acquired in process research and development expenses of the Company
            for the Marsam acquisition to the extent such charge is less than
            $35,000,000 plus (a) the lesser of (i) the amount of any non-cash
            Steris Charges taken by the Borrower and the Subsidiaries and (ii)
            $117,000,000, plus (b) the amount of a non-cash impairment charge
            for Marsam Pharmaceutical, Inc. in a pre-tax amount not to exceed
            $63,000,000 to be recorded by the Borrower as of December 25, 1999.

            SECTION 3. Certain Agreements of the Company. (a) The Borrower
agrees, not later than March 3, 2000, to deliver to the Administrative Agent,
with a copy for each Lender, (i) projected balance sheets, income statements,
statements of cash flows and covenant levels, including projection assumptions,
for each financial quarter from the date hereof to and including the Maturity
Date with respect to the Borrower and its consolidated Subsidiaries, (ii)
information, satisfactory to the Administrative Agent, with respect to the
extraordinary charges to be recorded by the Borrower as of December 25, 1999,
(iii) a balance sheet, income statement and statement of cash flows for the year
ended December 25, 1999 and (iv) an income statement for December, 1999.

      (b) Without limiting the obligations of the Borrower under Section 9.05 of
the Credit Agreement, the Borrower agrees from time to time upon demand to pay
the reasonable fees and the out-of-pocket expenses of (i) financial advisors
retained by the Administrative Agent on behalf of the Lenders and (ii) such
additional counsel and other consultants as the Administrative Agent shall deem
it advisable to retain to provide advice to the Administrative Agent and the
Lenders.

      (c) The Borrower agrees to pay to the Administrative Agent on the
Effective Date a fee of $100,000 to be distributed by the Administrative Agent
among the Lenders that shall have executed this Waiver and Amendment on or prior
to 12:00 noon, New York City time, on such date ratably in accordance with the
amounts of their outstanding Loans, L/C Exposures and unused Revolving Credit
Commitments.

      (d) The Borrower agrees (i) subject to the obtaining of required consents
from landlords, promptly, and not later than March 1, 2000, to execute and
deliver and to cause the Domestic Subsidiaries to execute and deliver such
mortgages with respect to leasehold interests held by the Borrower and the
Domestic Subsidiaries as shall have

<PAGE>
                                                                               3

been requested by the Collateral Agent and (ii) to use its best efforts promptly
to obtain all such landlord consents as shall be required to permit the
execution and delivery of the mortgages referred to in the preceding clause (i).

            SECTION 4. Representations and Warranties. The Borrower represents
and warrants to each of the Lenders and the Administrative Agent that:

                  (i) After giving effect to this Waiver, the representations
            and warranties set forth in Article III of the Credit Agreement are
            true and correct in all material respects with the same effect as if
            made on and as of the date hereof.

                  (ii) After giving effect to this Waiver, no Event of Default
            or Default has occurred and is continuing.

            SECTION 5. Conditions to Effectiveness of Waivers and Amendments.
The waivers set forth in Section 1 and the amendments set forth in Section 2
shall become effective as of the date of this Waiver and Amendment, but only
upon the satisfaction on or prior to the date hereof of the following conditions
precedent (the date on which the last of such conditions is satisfied being
called the "Effective Date"):

                  (a) the Administrative Agent shall have received counterparts
            of this Waiver and Amendment that, when taken together, bear the
            signatures of the Borrower and the Required Lenders;

                  (b) the Administrative Agent shall have received in
            immediately available funds the Waiver Fee referred to in Section 3;

                  (c) the Administrative Agent shall have received such evidence
            as it or its counsel shall have requested as to the corporate power
            and authority of the Borrower to enter into and perform its
            obligations under this Waiver and Amendment;

                  (d) the representations and warranties set forth in Section 4
            shall be true and correct; and

                  (e) the Borrower and the Domestic Subsidiaries shall have
            executed and delivered all such amendments to the Pledge Agreement
            and other instruments and documents as shall have been requested by
            the Collateral Agent in order to subject to the Lien of the Pledge
            Agreement and to perfect the Lien of the Pledge Agreement in all
            equity interests owned by the Borrower and the Domestic Subsidiaries
            in persons that are not Subsidiaries.

            SECTION 6. Credit Agreement. Except as expressly set forth herein,
this Waiver and Amendment shall not by implication or otherwise limit, impair,
constitute a waiver of, or otherwise affect the rights and remedies of the
Lenders and the Administrative Agent under the Credit Agreement, or alter,
modify, amend or in any way affect any of the terms, conditions, obligations,
covenants or agreements contained in the Credit Agreement, all of which are
ratified and affirmed in all respects and shall continue in full force and
effect. This Waiver and Amendment shall apply and be effective only with respect
to the provisions of the Credit Agreement specifically referred to herein. The
agreements set forth in this Waiver and Amendment shall be deemed for all
purposes to be covenants contained in Article VI of the Credit Agreement as
amended hereby, and

<PAGE>
                                                                               4

the failure of the Borrower to perform any of such agreements in accordance with
the terms thereof shall constitute an Event of Default under the Credit
Agreement as so amended.

            SECTION 7. Expenses. The Borrower agrees to reimburse the
Administrative Agent for (a) the fees and expenses referred to in Section 3(c)
and (b) its out-of-pocket expenses reasonably incurred in connection with this
Waiver and Amendment, including the reasonable fees, charges and disbursements
of Cravath, Swaine & Moore, counsel for the Administrative Agent.

            SECTION 8. Applicable Law. THIS WAIVER SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

            SECTION 9. Counterparts. This Waiver and Amendment may be executed
in two or more counterparts, each of which shall constitute an original but all
of which when taken together shall constitute but one contract. Delivery of an
executed counterpart of a signature page of this Waiver and Amendment by
telecopy shall be

<PAGE>
                                                                               5

effective as delivery of a manually executed counterpart of this Waiver and
Amendment.

            IN WITNESS WHEREOF, the parties hereto have caused this Waiver and
Amendment to be duly executed by their respective authorized officers as of the
day and year first written above.

                              SCHEIN PHARMACEUTICAL, INC.,

                              by /s/ James A. Meer
                                 -----------------------------------------------
                                 Name:  James A. Meer
                                 Title: Vice President & Treasurer

                              THE CHASE MANHATTAN BANK, individually and as
                              Administrative Agent, Collateral Agent and Issuing
                              Bank,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NEW YORK,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NOVA SCOTIA,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

<PAGE>
                                                                               5

effective as delivery of a manually executed counterpart of this Waiver and
Amendment.

            IN WITNESS WHEREOF, the parties hereto have caused this Waiver and
Amendment to be duly executed by their respective authorized officers as of the
day and year first written above.

                              SCHEIN PHARMACEUTICAL, INC.,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE CHASE MANHATTAN BANK, individually and as
                              Administrative Agent, Collateral Agent and Issuing
                              Bank,

                              by /s/ Dawn Lee Lum
                                 -----------------------------------------------
                                 Name:  Dawn Lee Lum
                                 Title: Vice President

                              THE BANK OF NEW YORK,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NOVA SCOTIA,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

<PAGE>
                                                                               5

effective as delivery of a manually executed counterpart of this Waiver and
Amendment.

            IN WITNESS WHEREOF, the parties hereto have caused this Waiver and
Amendment to be duly executed by their respective authorized officers as of the
day and year first written above.

                              SCHEIN PHARMACEUTICAL, INC.,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE CHASE MANHATTAN BANK, individually and as
                              Administrative Agent, Collateral Agent and Issuing
                              Bank,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NEW YORK,

                              by /s/ Michael B. Scaduto
                                 -----------------------------------------------
                                 Name:  Michael B. Scaduto
                                 Title: Vice President

                              THE BANK OF NOVA SCOTIA,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

<PAGE>
                                                                               5

effective as delivery of a manually executed counterpart of this Waiver and
Amendment.

            IN WITNESS WHEREOF, the parties hereto have caused this Waiver and
Amendment to be duly executed by their respective authorized officers as of the
day and year first written above.

                              SCHEIN PHARMACEUTICAL, INC.,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE CHASE MANHATTAN BANK, individually and as
                              Administrative Agent, Collateral Agent and Issuing
                              Bank,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NEW YORK,

                              by
                                 -----------------------------------------------
                                 Name:
                                 Title:

                              THE BANK OF NOVA SCOTIA,

                              by /s/ John Campbell
                                 -----------------------------------------------
                                 Name:  John Campbell
                                 Title: Managing Director

<PAGE>
                                                                               6

                                         BANK OF TOKYO-MITSUBISHI TRUST COMPANY,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         BAYERISCHE HYPOTHEKEN-UND WECHSEL-
                                         BANK AKTIENGESSELLSCHAFT, NEW YORK
                                         BRANCH,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMERICA BANK,

                                         by /s/ Ashley S. Yashin
                                            ------------------------------------
                                            Name:  Ashley S. Yashin
                                            Title: Account Officer

                                         COMMERCIAL LOAN FUNDING TRUST I,

                                              by LEHMAN COMMERCIAL PAPER, INC.,
                                              not in its individual capacity but
                                              solely as Administrative Agent

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMMERZBANK AKTIENGESELLSHAFT, NEW
                                         YORK BRANCH,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

<PAGE>
                                                                               6

                                         BANK OF TOKYO-MITSUBISHI TRUST COMPANY,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         BAYERISCHE HYPOTHEKEN-UND WECHSEL-
                                         BANK AKTIENGESSELLSCHAFT, NEW YORK
                                         BRANCH,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMERICA BANK,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMMERCIAL LOAN FUNDING TRUST I,

                                              by LEHMAN COMMERCIAL PAPER, INC.,
                                              not in its individual capacity but
                                              solely as Administrative Agent

                                         by /s/ William J. Gallagher
                                            ------------------------------------
                                            Name:  WILLIAM J. GALLAGHER
                                            Title: AUTHORIZED SIGNATORY

                                         COMMERZBANK AKTIENGESELLSHAFT, NEW
                                         YORK BRANCH,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

<PAGE>
                                                                               6

                                         BANK OF TOKYO-MITSUBISHI TRUST COMPANY,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         BAYERISCHE HYPOTHEKEN-UND WECHSEL-
                                         BANK AKTIENGESSELLSCHAFT, NEW YORK
                                         BRANCH,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMERICA BANK,

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMMERCIAL LOAN FUNDING TRUST I,

                                              by LEHMAN COMMERCIAL PAPER, INC.,
                                              not in its individual capacity but
                                              solely as Administrative Agent

                                         by
                                            ------------------------------------
                                            Name:
                                            Title:

                                         COMMERZBANK AKTIENGESELLSHAFT, NEW
                                         YORK BRANCH,

                                         by /s/ Andrew R. Campbell
                                            ------------------------------------
                                            Name:  Andrew R. Campbell
                                            Title: Assistant Vice President

                                         by /s/ G. Rod McWalters
                                            ------------------------------------
                                            Name:  G. Rod McWalters
                                            Title: Senior Vice President

<PAGE>
                                                                               7

                                         COOPERATIEVE CENTRALE RAIFFEIFEN-
                                         BOERENLEENBANK, B.A., "RABOBANK
                                         NEDERLAND", NEW YORK BRANCH,

                                         by /s/ Nancy J. O'Connor
                                            ------------------------------------
                                            Name:  Nancy J. O'Connor
                                            Title: Vice President

                                         by /s/ Richard [ILLEGIBLE]
                                            ------------------------------------
                                            Name:  Richard [ILLEGIBLE]
                                            Title: V.P

<PAGE>
                                                                               8

                                     DEUTSCHE BANK, A.G., NEW YORK AND/OR CAYMAN
                                     ISLAND BRANCHES,

                                     by /s/ Iain Stewart
                                        ----------------------------------------
                                        Name:  Iain Stewart
                                        Title: Vice President

                                     by /s/ [ILLEGIBLE] Spear
                                        ----------------------------------------
                                        Name:  [ILLEGIBLE] Spear
                                        Title: Director

                                     DG BANK DEUTSCHE GENOSSENSCHAFTSBANK,
                                     CAYMAN ISLAND BRANCH,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FIRST UNION NATIONAL BANK,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FLEET BANK, N.A. (formerly known as
                                     NatWest Bank, N.A.),

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     KEYBANK NATIONAL ASSOCIATION,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

<PAGE>
                                                                               8

                                     DEUTSCHE BANK, A.G., NEW YORK AND/OR CAYMAN
                                     ISLAND BRANCHES,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     DG BANK DEUTSCHE GENOSSENSCHAFTSBANK, AG
                                     CAYMAN ISLAND BRANCH,

                                     by /s/ Sabine Wendt
                                        ----------------------------------------
                                        Name:  SABINE WENDT
                                        Title: Vice President

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FIRST UNION NATIONAL BANK,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FLEET BANK, N.A. (formerly known as
                                     NatWest Bank, N.A.),

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     KEYBANK NATIONAL ASSOCIATION,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

<PAGE>
                                                                               8

                                     DEUTSCHE BANK, A.G., NEW YORK AND/OR CAYMAN
                                     ISLAND BRANCHES,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     DG BANK DEUTSCHE GENOSSENSCHAFTSBANK, AG
                                     CAYMAN ISLAND BRANCH,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FIRST UNION NATIONAL BANK,

                                     by /s/ Stuart Kratter
                                        ----------------------------------------
                                        Name:  STUART KRATTER
                                        Title: SVP

                                     FLEET BANK, N.A. (formerly known as
                                     NatWest Bank, N.A.),

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     KEYBANK NATIONAL ASSOCIATION,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

<PAGE>
                                                                               8

                                     DEUTSCHE BANK, A.G., NEW YORK AND/OR CAYMAN
                                     ISLAND BRANCHES,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     DG BANK DEUTSCHE GENOSSENSCHAFTSBANK, AG
                                     CAYMAN ISLAND BRANCH,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FIRST UNION NATIONAL BANK,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

                                     FLEET BANK, N.A. (formerly known as
                                     NatWest Bank, N.A.),

                                     by /s/ [ILLEGIBLE]
                                        ----------------------------------------
                                        Name:  [ILLEGIBLE]
                                        Title: VICE PRESIDENT

                                     KEYBANK NATIONAL ASSOCIATION,

                                     by
                                        ----------------------------------------
                                        Name:
                                        Title:

<PAGE>
                                                                               9

                                           MELLON BANK, N.A.,

                                           by /s/ Walter J. Letts
                                              ----------------------------------
                                              Name:  WALTER J. LETTS
                                              Title: VICE PRESIDENT

                                           PNC BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SOCIETE GENERALE, NEW YORK BRANCH,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SUMMIT BANK,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           WESTDEUTSCHE LANDESBANK GIROZENTRALE,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

<PAGE>
                                                                               9

                                           MELLON BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           PNC BANK, N.A.,

                                           by  /s/ Michael Nardo
                                              ----------------------------------
                                              Name:  Michael Nardo
                                              Title: Vice President

                                           SOCIETE GENERALE, NEW YORK BRANCH,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SUMMIT BANK,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           WESTDEUTSCHE LANDESBANK GIROZENTRALE,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

<PAGE>
                                                                               9

                                           MELLON BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           PNC BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SOCIETE GENERALE, NEW YORK BRANCH,

                                           by /s/ Cynthia A. Jay
                                              ----------------------------------
                                              Name:  Cynthia A. Jay
                                              Title: Managing Director

                                           SUMMIT BANK,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           WESTDEUTSCHE LANDESBANK GIROZENTRALE,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

<PAGE>
                                                                               9

                                           MELLON BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           PNC BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SOCIETE GENERALE, NEW YORK BRANCH,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SUMMIT BANK,

                                           by /s/ Christopher P. Klegkowski
                                              ----------------------------------
                                              Name:  Christopher P. Klegkowski
                                              Title: SVP

                                           WESTDEUTSCHE LANDESBANK GIROZENTRALE,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

<PAGE>
                                                                               9

                                           MELLON BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           PNC BANK, N.A.,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SOCIETE GENERALE, NEW YORK BRANCH,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           SUMMIT BANK,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           WESTDEUTSCHE LANDESBANK GIROZENTRALE,

                                           by /s/ Richard J. Pearse
                                              ----------------------------------
                                              Name:  Richard J. Pearse
                                              Title: Managing Director

                                           by /s/ Elisabeth R. Wilds
                                              ----------------------------------
                                              Name:  Elisabeth R. Wilds
                                              Title: Associate

<PAGE>
                                                                              13

                                           BAYERISCHE HYPO-UND
                                           VEREINSBANK AG

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           COMMERZBANK AG, NEW YORK
                                           BRANCH

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           BAYERISCHE LANDESBANK
                                           GIROZENTRALE,

                                           by
                                              ----------------------------------
                                              Name:
                                              Title:

                                           DRESDNER BANK AG, NEW YORK
                                           AND GRAND CAYMAN ISLANDS,

                                           by /s/ John P. Fieseler
                                              ----------------------------------
                                              Name:  John P. Fieseler
                                              Title: Senior Vice President

                                           /s/ Patrick A. Keleher
                                           -------------------------------------
                                           Name:  PATRICK A. KELEHER
                                           Title: Vice President<PAGE>

                                                                  CONFORMED COPY

                        FIRST AMENDMENT AND CONSENT dated as of March 15, 2000
                  (this "Amendment"), to the Waiver and First Amendment dated as
                  of February 7, 2000 (the "Waiver") of the Amended and Restated
                  Credit Agreement (the "Credit Agreement") dated as of November
                  6, 1998, as amended by the Waiver, among SCHEIN
                  PHARMACEUTICAL, INC., a Delaware corporation (the "Borrower"),
                  the lenders party hereto (the "Lenders") and THE CHASE
                  MANHATTAN BANK, a New York banking corporation, as
                  administrative agent for the Lenders (in such capacity, the
                  "Administrative Agent"), as issuing bank and as collateral
                  agent.

            A. Pursuant to the Credit Agreement, the Lenders and the Issuing
Bank have extended credit to the Borrower, and have agreed to extend credit to
the Borrower, in each case pursuant to the terms and subject to the conditions
set forth therein.

            B. The Borrower has requested that the Waiver be amended as set
forth herein.

            C. The Borrower has also informed the Administrative Agent that it
intends to sell all of its 135,000 shares of capital stock of Bone Care
International (the "Bone Care Sale"). The Borrower has requested that the
Lenders consent to such sale and to the retention and reinvestment of any
proceeds from such sale in the Borrower's business.

            D. The Required Lenders are willing to amend the Waiver and grant
the requested consent pursuant to the terms and subject to the conditions set
forth herein.

            E. Capitalized terms used and not otherwise defined herein shall
have the meanings assigned to them in the Credit Agreement.

            In consideration of the premises and the agreements, provisions and
covenants herein contained, the parties hereto hereby agree, on the terms and
subject to the conditions set forth herein, as follows:

            SECTION 1. Amendment to the Waiver.

            (a) Section 1 of the Waiver is hereby amended and restated in its
entirety as follows:

                  (a) Subject to Section 5 below, the undersigned Lenders hereby
            waive compliance, at all times on or after September 26, 1999, and
            on or prior to March 24, 2000, with the covenants contained in (i)
            Section 6.14 of the Credit Agreement; (ii) Section 6.17 of the
            Credit Agreement; and (iii) Section 6.18 of the Credit Agreement.
            The waivers provided for in the preceding sentence will terminate on
            the earlier of (x) 5:00 p.m., New York City time, on March 24, 2000,
            (y) any date on which an Event of Default shall occur under the
            Credit Agreement (giving effect to the waiver provided for in this
            Section) and (z) any date on which the Borrower shall fail to
            perform any of its undertakings under this Waiver

<PAGE>
                                                                               2

            and Amendment (the first to occur of the dates referred to in the
            preceding clauses (x), (y) and (z) being called the "Termination
            Date").

            SECTION 2.  Consent.  The Lenders hereby consent to the Bone Care
Sale and to the retention and reinvestment of all proceeds therefrom in the
business of the Borrower.

            SECTION 3.  Representations and Warranties.  The Borrower represents
and warrants to each of the Lenders and the Administrative Agent that:

            (i) After giving effect to this Amendment, the representations and
      warranties set forth in Article III of the Credit Agreement are true and
      correct in all material respects with the same effect as if made on and as
      of the date hereof.

            (ii) After giving effect to this Amendment, no Event of Default or
      Default has occurred and is continuing.

            SECTION 4. Conditions to Effectiveness of Amendments. The amendment
set forth in Section 1 shall become effective as of the date of this Amendment,
but only upon the satisfaction on or prior to the date hereof of the following
conditions precedent (the date on which the last of such conditions is satisfied
being called the "Effective Date"):

            (a) the Administrative Agent shall have received counterparts of
      this Amendment that, when taken together, bear the signatures of the
      Borrower and the Required Lenders; and

            (b) the representations and warranties set forth in Section 3 shall
      be true and correct.

            SECTION 5. Credit Agreement. Except as expressly set forth herein,
this Amendment shall not by implication or otherwise limit, impair, constitute a
waiver of, or otherwise affect the rights and remedies of the Lenders and the
Administrative Agent under the Credit Agreement, or alter, modify, amend or in
any way affect any of the terms, conditions, obligations, covenants or
agreements contained in the Credit Agreement, all of which are ratified and
affirmed in all respects and shall continue in full force and effect. This
Amendment shall apply and be effective only with respect to the provisions of
the Credit Agreement specifically referred to herein. The agreements set forth
in this Amendment shall be deemed for all purposes to be covenants contained in
Article VI of the Credit Agreement as amended hereby, and the failure of the
Borrower to perform any of such agreements in accordance with the terms thereof
shall constitute an Event of Default under the Credit Agreement as so amended.
This Amendment shall constitute a "Loan Document" for all purposes of the Credit
Agreement and the other Loan Documents.

            SECTION 6. Expenses. The Borrower agrees to reimburse the
Administrative Agent for its out-of-pocket expenses reasonably incurred in
connection with this Amendment, including, without limitation, the reasonable
fees, charges and disbursements of Cravath, Swaine & Moore, counsel for the
Administrative Agent.

<PAGE>
                                                                               3

            SECTION 7. Applicable Law. THIS AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

            SECTION 8. Counterparts. This Amendment may be executed in two or
more counterparts, each of which shall constitute an original but all of which
when taken together shall constitute but one contract. Delivery of an executed
counterpart of a signature page of this Amendment by facsimile shall be
effective as delivery of a manually executed counterpart of this Amendment.

<PAGE>
                                                                               4

            IN WITNESS WHEREOF, the parties hereto have caused this Amendment to
be duly executed by their respective authorized officers as of the day and year
first written above.

                             SCHEIN PHARMACEUTICAL, INC.,

                             by /s/ James A. Meer
                               -----------------------------------------
                                Name:  James. A. Meer
                                Title: Vice President & Treasurer

                             THE CHASE MANHATTAN BANK, individually
                             and as Administrative Agent, Collateral Agent and
                             Issuing Bank,

                             by /s/ Dawn Lee Lum
                               -----------------------------------------
                               Name:  Dawn Lee Lum
                               Title: Vice President

                             AG CAPITAL FUNDING PARTNERS, L.P.,

                             by /s/ Jeff Aronson
                               -----------------------------------------
                               Name:  Jeff Aronson
                               Title: Managing Director

                             BEAR, STEARNS & CO. INC.,

                             by /s/ Gregory A. Hanley
                               -----------------------------------------
                               Name:  Gregory A. Hanley
                               Title: Senior Managing Director

                             COMMERCIAL LOAN FUNDING TRUST I,

                                    by: LEHMAN COMMERCIAL PAPER,
                                    INC., not in its individual capacity but
                                    solely as Administrative Agent

                             by /s/ Michele Swanson
                               -----------------------------------------
                               Name:  Michele Swanson
                               Title: Authorized Signatory

<PAGE>
                                                                               5

                             COOPERATIEVE CENTRALE RAIFFEIFEN-
                             BOERENLEENBANK, B.A., "RABOBANK
                             NEDERLAND", NEW YORK BRANCH,

                             by /s/ Richard Matther
                               -----------------------------------------
                               Name:  Richard Matther
                               Title: Vice President

                             by /s/ Jeffrey Vollack
                                -----------------------------------------
                               Name:  Jeffrey Vollack
                               Title: Senior Vice President

                             DG BANK DEUTSCHE
                             GENOSSENSCHAFTSBANK, CAYMAN
                             ISLAND BRANCH,

                             by /s/ Sabine Wendt
                               -----------------------------------------
                               Name:  Sabine Wendt
                               Title: Vice President

                             by /s/ Rob T. Jokhai
                               -----------------------------------------
                               Name:  Rob T. Jokhai
                               Title: Vice President

                            FIRST UNION NATIONAL BANK,

                             by /s/ Stuart Kratter
                               -----------------------------------------
                               Name:  Stuart Kratter
                               Title: Senior Vice President

                             FLEET BANK, N.A. (formerly known as NatWest
                             Bank, N.A.),

                             by /s/ Edward J. Walsh
                               -----------------------------------------
                               Name:  Edward J. Walsh
                               Title: Senior Vice President

                             MELLON BANK, N.A.,

                             by /s/ Walter J. Letts
                               -----------------------------------------
                               Name:  Walter J. Letts
                               Title: Vice President

<PAGE>
                                                                               6

                             SOCIETE GENERALE, NEW YORK BRANCH,

                             by /s/ Cynthia A. Jay
                               -----------------------------------------
                               Name:  Cynthia A. Jay
                               Title: Managing Director

                             THE BANK OF NOVA SCOTIA,

                             by /s/ Brian S. Allen
                                -----------------------------------------
                               Name:  Brian S. Allen
                               Title: Managing Director

                             BANK OF TOKYO-MITSUBISHI TRUST
                             COMPANY,

                             by
                               _________________________________________
                               Name:
                               Title:

                             BAYERISCHE HYPOTHEKEN-UND
                             WECHSEL-BANK AKTIENGESSELLSCHAFT,
                             NEW YORK BRANCH,

                             by
                               _________________________________________
                               Name:
                               Title:

                             by
                               _________________________________________
                               Name:
                               Title:

                             COMERICA BANK,

                             by
                               _________________________________________
                               Name:
                               Title:
<PAGE>
                                                                               7

                             DEUTSCHE BANK, A.G. NEW YORK AND/OR
                             CAYMAN ISLAND BRANCHES,

                             by
                                _________________________________________
                               Name:
                               Title:

                             by
                               _________________________________________
                               Name:
                               Title:

                             KEYBANK NATIONAL ASSOCIATION,

                             by
                               _________________________________________
                               Name:
                               Title:

                             PNC BANK, N.A.,

                             by
                               _________________________________________
                               Name:
                               Title:

                             SUMMIT BANK,

                             by
                                _________________________________________
                               Name:
                               Title:

<PAGE>

                             THE BANK OF NOVA SCOTIA,

                             by /s/ Brian S. Allen
                               ----------------------------------------
                               Name:  Brian S. Allen
                               Title: Managing Director

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