Document:

exv10w1

Exhibit 10.1

 

 

$1,500,000.00

DEBTOR-IN-POSSESSION CREDIT AND SECURITY AGREEMENT

by and between

VERMILLION, INC.,

As a Debtor and Debtor-in-Possession

and

QUEST DIAGNOSTICS INCORPORATED,

As Lender

Dated as of October 7, 2009

 

 

 

 

Table of Contents

	 	 	 	 	 	 	 
	 
	 	 	 	Page
	Section 1

	 	DEFINITIONS AND CONSTRUCTION
	 	 	1	 
	1.1

	 	Definitions
	 	 	1	 
	1.2

	 	UCC
	 	 	9	 
	1.3

	 	Construction
	 	 	9	 
	1.4

	 	Exhibits
	 	 	9	 
	 
	 	 	 	 	 	 
	Section 2

	 	LOAN AND TERMS OF PAYMENT
	 	 	9	 
	2.1

	 	Advances
	 	 	9	 
	2.2

	 	Overadvances
	 	 	10	 
	2.3

	 	Interest: Rates, Payments, and Calculations
	 	 	10	 
	2.4

	 	Repayment of Obligations
	 	 	11	 
	2.5

	 	Crediting Payments; Application of Collections
	 	 	11	 
	 
	 	 	 	 	 	 
	Section 3

	 	CONDITIONS; TERM
	 	 	12	 
	3.1

	 	Conditions Precedent to Initial Advance
	 	 	12	 
	3.2

	 	Conditions Precedent to Each Advance
	 	 	13	 
	3.3

	 	Term
	 	 	14	 
	3.4

	 	Effect of Termination
	 	 	14	 
	 
	 	 	 	 	 	 
	Section 4

	 	CREATION OF SECURITY INTERESTS, LIENS
	 	 	14	 
	4.1

	 	Grant of Security Interests and Liens
	 	 	14	 
	4.2

	 	Negotiable Collateral
	 	 	15	 
	4.3

	 	Delivery of Additional Documentation Required
	 	 	15	 
	4.4

	 	Power of Attorney
	 	 	15	 
	4.5

	 	Right to Inspect
	 	 	16	 
	 
	 	 	 	 	 	 
	Section 5

	 	REPRESENTATIONS AND WARRANTIES
	 	 	16	 
	5.1

	 	No Prior Encumbrances
	 	 	16	 
	5.2

	 	Due Organization and Qualification
	 	 	17	 
	5.3

	 	Due Authorization; No Conflict
	 	 	17	 
	5.4

	 	Priority and Liens
	 	 	17	 
	5.5

	 	Further Assurances
	 	 	18	 
	5.6

	 	Information Regarding Collateral
	 	 	19	 
	5.7

	 	Reliance by Lender; Cumulative
	 	 	19	 

 

 

	 	 	 	 	 	 	 
	 
	 	 	 	Page
	Section 6

	 	AFFIRMATIVE COVENANTS
	 	 	19	 
	6.1

	 	Maintenance of Property
	 	 	19	 
	6.2

	 	Books and Records; Inspection
	 	 	19	 
	6.3

	 	Notices
	 	 	19	 
	6.4

	 	Taxes
	 	 	20	 
	6.5

	 	Insurance
	 	 	20	 
	6.6

	 	No Setoffs or Counterclaims
	 	 	20	 
	6.7

	 	Compliance with Laws
	 	 	20	 
	6.8

	 	Budget
	 	 	21	 
	 
	 	 	 	 	 	 
	Section 7

	 	NEGATIVE COVENANTS
	 	 	21	 
	7.1

	 	Liens
	 	 	21	 
	7.2

	 	Indebtedness
	 	 	21	 
	7.3

	 	No Disposition
	 	 	22	 
	7.4

	 	Mergers/Asset Sales/Asset Purchases
	 	 	22	 
	7.5

	 	No Subsidiaries
	 	 	22	 
	7.6

	 	Conduct of Business
	 	 	22	 
	7.7

	 	Pre-Petition Claims / Budget Compliance
	 	 	22	 
	 
	 	 	 	 	 	 
	Section 8

	 	EVENTS OF DEFAULT
	 	 	23	 
	8.1

	 	Events of Default
	 	 	23	 
	8.2

	 	Exercise of Rights
	 	 	25	 
	 
	 	 	 	 	 	 
	Section 9

	 	LENDER’S RIGHTS AND REMEDIES
	 	 	26	 
	9.1

	 	Rights and Remedies
	 	 	26	 
	9.2

	 	Remedies Cumulative
	 	 	27	 
	 
	 	 	 	 	 	 
	Section 10

	 	TAXES AND EXPENSES
	 	 	27	 
	 
	 	 	 	 	 	 
	Section 11

	 	WAIVERS; INDEMNIFICATION
	 	 	28	 
	11.1

	 	Demand; Protest; etc
	 	 	28	 
	11.2

	 	Lender’s Liability for Collateral
	 	 	28	 
	11.3

	 	Indemnification
	 	 	28	 
	 
	 	 	 	 	 	 
	Section 12

	 	NOTICES
	 	 	28	 
	 
	 	 	 	 	 	 
	Section 13

	 	CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER
	 	 	29	 
	 
	 	 	 	 	 	 
	Section 14

	 	GENERAL PROVISIONS
	 	 	30	 
	14.1

	 	Effectiveness
	 	 	30	 
	14.2

	 	Successors and Assigns
	 	 	30	 

36

 

	 	 	 	 	 	 	 
	 
	 	 	 	Page
	14.3

	 	Section Headings
	 	 	30	 
	14.4

	 	Interpretation
	 	 	30	 
	14.5

	 	Good Faith
	 	 	30	 
	14.6

	 	Severability of Provisions
	 	 	30	 
	14.7

	 	Amendments, etc
	 	 	31	 
	14.8

	 	Confidentiality
	 	 	31	 
	14.9

	 	Counterparts; Telefacsimile Execution
	 	 	31	 
	14.10

	 	Revival and Reinstatement of Obligations
	 	 	31	 
	14.11

	 	Integration
	 	 	31	 

	 	 	 
	Exhibit 1
	 	Budget

	Exhibit 2
	 	Interim Order

	Exhibit 3
	 	Note

	Exhibit 4
	 	Notice of Borrowing

	Exhibit 5
	 	Strategic Alliance Agreement

37

 

DEBTOR-IN-POSSESSION CREDIT AND SECURITY AGREEMENT

          THIS DEBTOR-IN-POSSESSION CREDIT AND SECURITY AGREEMENT (as amended, restated, supplemented or
otherwise modified from time to time, this “Agreement”) is made and entered into as of
October 7, 2009, by and between Vermillion, Inc., a Delaware corporation and a debtor and
debtor-in-possession under Chapter 11 of the Bankruptcy Code (“Borrower”), and Quest
Diagnostics Incorporated, a Delaware corporation (in its capacity as lender hereunder,
“Lender”).

RECITALS

          A. On March 30, 2009 (the “Petition Date”), Borrower filed a voluntary petition for
relief, thereby commencing case no. 09-11091 (CSS) (the “Case”) pursuant to Chapter 11 of
Title 11 of the United States Code, 11 U.S.C. §§ 101 et seq. (as in effect for
purposes of the Case, the “Bankruptcy Code”), in the United States Bankruptcy Court for the
District of Delaware (the “Bankruptcy Court”) and has continued in possession of its assets
and in the management of its business as a debtor-in-possession pursuant to Sections 1107(a) and
1108 of the Bankruptcy Code.

          B. Borrower has requested that Lender provide a senior secured superpriority term loan
facility of up to $1,500,000.00 (one million five hundred thousand dollars) on the terms and
conditions set forth herein for general working capital and corporate purposes of Borrower, in
accordance with the Budget and the Loan Documents as more fully described herein.

          C. Borrower has agreed to secure its obligations hereunder by granting to Lender security
interests in and liens upon all of Borrower’s existing and after-acquired assets, as more fully
described herein.

          NOW, THEREFORE, in consideration of the premises and the mutual covenants hereinafter
contained, and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto agree as follows:

SECTION 1

DEFINITIONS AND CONSTRUCTION

          1.1 Definitions. As used in this Agreement, the following terms shall have the following
definitions:

          “Accounts” means all of Borrower’s now owned or hereafter acquired right, title, and
interest with respect to “accounts” (as that term is defined in the UCC), and any and all
supporting obligations in respect thereof.

          “Actual Disbursement Amount” means the actual amount of all disbursements made by
Borrower during the relevant period.

-1-

 

          “Actual Receipts Amount” means the actual amount of all receipts received by Borrower
during the relevant Period.

          “Advance” has the meaning set forth in Section 2.1(a) of this Agreement.

          “Agreement” has the meaning set forth in the introduction to this Agreement.

          “Authorized Officer” means, as applied to any Person, any individual holding the
position of chairman of the board (if an office), chief executive officer, president or one of its
vice presidents (or the equivalent thereof), and such Person’s chief financial officer or
treasurer.

          “Avoidance Action” means any claim, action or cause of action under Sections 544, 547,
548 or 550 of the Bankruptcy Code, and proceeds relating thereof or arising therefrom.

          “Bankruptcy Code” has the meaning set forth in the Recitals to this Agreement.

          “Bankruptcy Court” has the meaning set forth in the Recitals to this Agreement.

          “Bankruptcy Orders” means, collectively and each individually, the Interim Order and
the Final Order.

          “Books” means all of Borrower’s now owned or hereafter acquired books and records
including: ledgers; records indicating, summarizing, or evidencing Borrower’s properties or assets
(including the Collateral) or liabilities; all information relating to Borrower’s business
operations or financial condition and all of its goods or General Intangibles related to such
information; and all computer programs, disc or tape files, printouts, runs, or other computer
prepared information, and the equipment containing such information.

          “Borrower” has the meaning set forth in the introduction to this Agreement.

          “Budget” means that certain record of expenses and revenue of Borrower for actual cash
revenues, receipts, expenses and disbursements and other information incurred and received from the
Petition Date through August 31, 2009 and forecast of cash revenues, receipts, expenses and
disbursements and other information for the period of four (4) consecutive months beginning on
September 1, 2009, attached hereto as Exhibit 1, and for such periods thereafter (if any)
during the term of this Agreement, in form and substance acceptable to Lender in its reasonable
discretion, as the same may be updated, modified or supplemented from time to time in accordance
with Section 6.9.

          “Budgeted Disbursement Amount” means the line item contained in the Budget under the
heading ‘Total Disbursements’ during the relevant Period of determination as set forth in the
Budget.

          “Budgeted Receipts Amount” means the line item contained in the Budget under the
heading ‘Total Receipts’ during the relevant Period of determination as set forth in the Budget.

-2-

 

          “Business Day” means any day which is not a Saturday, Sunday, or other day on which
national banks are authorized or required to close.

          “Carve-Out” has the meaning given such term in Section 5.4(a)(iv).

          “Case” has the meaning set forth in the Recitals to this Agreement.

          “Collateral” means all of Borrower’s now owned or hereafter acquired right, title, and
interest in and to each of the following:

               (a) Accounts;

               (b) Books;

               (c) Goods and Equipment;

               (d) General Intangibles (specifically including Intellectual Property, but excluding rights
relating to Avoidance Actions);

               (e) Inventory;

               (f) Investment Property;

               (g) Negotiable Collateral;

               (h) Real Property and fixtures;

               (i) Money or other assets of Borrower that now or hereafter come into the possession, custody,
or control of Lender (other than proceeds of Avoidance Actions);

               (j) All present and future rights, titles, and interests that Borrower may now have or be or
become entitled to under or by virtue of any licenses, consents, permits, franchises, variances,
certifications and approvals of governmental agencies and all other similar tangible and intangible
property of Borrower and the proceeds thereof; and

               (k) Proceeds and products, whether tangible or intangible, of any of the foregoing, including
proceeds of insurance covering any or all of the foregoing, including without limitation any and
all Accounts, Books, Equipment, Fixtures, General Intangibles, Inventory, Investment Property,
Negotiable Collateral, Real Property, money, deposit accounts, or other tangible or intangible
property resulting from the sale, exchange, collection, or other disposition of any of the
foregoing, or any portion thereof or interest therein, and the proceeds thereof (other than
Avoidance Actions and the proceeds thereof).

          “Cumulative Period” means the period from September 1, 2009 through the most recent
month then ended.

          “Default” has the meaning given such term in Section 3.2(c).

-3-

 

          “Default Interest Rate” means the Non-Default Interest Rate plus six percent (6%) per
annum.

          “Disposition” or “Dispose” means the sale, transfer, license, lease or other
disposition of any property by any Person (or the granting of any option or other right to do any
of the foregoing), including any sale, assignment, transfer or other disposal, with or without
recourse, of any notes or receivables or any rights and claims associated therewith.

          “Environmental Laws” means all laws, rules, regulations, codes, ordinances, orders,
decrees, judgments, injunctions, notices, Environmental Permits, or binding agreements issued,
promulgated or entered into by any Governmental Authority, relating to the protection of the
environment, preservation or reclamation of natural resources, the management, release or
threatened release of any Hazardous Material or to health and safety matters.

          “Environmental Permit” means any federal, state, local, provincial, or foreign
permits, licenses, approvals, consents or authorizations required or issued by any Governmental
Authority under or in connection with any Environmental Law.

          “Equipment” has the meaning given to such term in the UCC.

          “Event of Default” has the meaning set forth in Article 8 hereof.

          “Existing Agreements” means all of the agreements granting security interests and
Liens in property and assets of Borrower to the Existing Lenders, including without limitation, the
following (each of which documents was executed and delivered by Borrower prior to the Petition
Date, as each may have been amended or modified from time to time): Credit Agreement by and between
Quest Diagnostics Incorporated and Ciphergen Biosystems, Inc. dated July 22, 2005 and Patent
Security Agreement by and between Quest Diagnostics Incorporated and Ciphergen Biosystems, Inc.
dated July 22, 2005.

          “Existing Indebtedness” means all Indebtedness and other obligations incurred by
Borrower under the Existing Agreements.

          “Existing Lenders” means the lenders from time to time holding Existing Indebtedness.

          “Financial Officer” means the chief financial officer, controller, corporate
controller, treasurer or corporate treasurer of Borrower, and shall include the chief executive
officer of the Borrower.

          “Final Order” means an order entered by the Bankruptcy Court in substantially the form
of the Interim Order, with only such modifications thereto as are satisfactory in form and
substance to Lender.

          “General Intangibles” has the meaning given to such term in the UCC.

          “Goods” has the meaning given to such term in the UCC.

-4-

 

          “Governmental Authority” means the government of the United States or any other
nation, or of any political subdivision thereof, whether state or local, and any agency, authority,
instrumentality, regulatory body, court, central bank or other entity exercising executive,
legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to
government (including any supra-national bodies such as the European Union or the European Central
Bank).

          “Hazardous Materials” means all explosive or radioactive substances or wastes and all
hazardous or toxic substances, wastes or other pollutants, including petroleum or petroleum
distillates, asbestos or asbestos containing materials, polychlorinated biphenyls, radon gas,
infectious or medical wastes and all other substances or wastes of any nature regulated pursuant to
any Environmental Law.

          “Indebtedness” means, as to any Person at any date, without duplication, (a) all
obligations of such Person for borrowed money, (b) all obligations of such Person evidenced by
bonds, debentures, notes, loan agreements or other similar instruments, (c) all obligations of such
Person to pay the deferred purchase price of property or services, except trade accounts payable
arising in the ordinary course of business and not past due for more than ninety (90) days after
the date on which such trade account was created, (d) all obligations of such Person as lessee
under capital leases, (e) all Indebtedness of others secured by an encumbrance on any asset of such
Person, whether or not such Indebtedness is assumed by such Person, (f) all Indebtedness of others
guaranteed by such Person and (g) the face amount of all letters of credit issued for the account
of such Person. For all purposes hereof, the Indebtedness of any person shall include the
Indebtedness of any partnership or joint venture (other than a joint venture that is itself a
corporation or limited liability company) in which such Person is a general partner or a joint
venturer, unless such Indebtedness is expressly made non-recourse to such Person.

          “Incentive Plan Participants” shall have the meaning set forth in the Order of the
Bankruptcy Court dated June 22, 2009 approving the motion to approve Borrower’s management
incentive plan.

          “Incentive Plan Payments” shall have the meaning set forth in the Order of the
Bankruptcy Court dated June 22, 2009 approving the motion to approve Borrower’s management
incentive plan.

          “Initial Advance” has the meaning set forth in Section 2.1(a) of this Agreement.

          “Intellectual Property” means all rights, priorities and privileges relating to
intellectual property, whether arising under United States, multi-national or foreign laws or
otherwise, including copyrights, copyright licenses, patents, patent licenses, trademarks,
trademark licenses, applications for any of the foregoing, software, technology, know-how and
processes, and all rights to sue at law or in equity for any infringement or other impairment
thereof, including the right to receive all proceeds and damages therefrom.

          “Interim Order” means an interim order under Sections 364 and 365 of the Bankruptcy
Code in substantially the form of Exhibit 2 hereto.

-5-

 

          “Interim Order Entry Date” means the date on which the Interim Order is entered by the
Bankruptcy Court in the Case following a hearing on Borrower’s motion for approval of this
Agreement.

          “Inventory” has the meaning given to such term in the UCC.

          “Investment Property” means all of Borrower’s now owned or hereafter acquired right,
title, and interest with respect to “investment property” as that term is defined in the UCC, and
any and all supporting obligations in respect thereof.

          “Lender Expenses” means all reasonable costs or expenses (including taxes,
photocopying, notarization, telecommunication and insurance premiums) required to be paid by
Borrower under any of the Loan Documents that are paid or advanced by Lender including
documentation, filing, recording, publication, appraisal, and search fees assessed, paid, or
incurred by Lender in connection with Lender’s loan to Borrower; costs and expenses incurred by
Lender in the disbursement of funds to Borrower (by wire transfer or otherwise); charges paid or
incurred by Lender resulting from the dishonor of checks; costs and expenses paid or incurred by
Lender to correct any default or enforce any provision of the Loan Documents, or in gaining
possession of, maintaining, handling, preserving, storing, shipping, selling, preparing for sale,
or advertising to sell the Collateral, or any portion thereof; costs and expenses paid or incurred
by Lender in examining the Books; costs and expenses of third party claims or any other suit paid
or incurred by Lender in enforcing or defending the Loan Documents; and Lender’s reasonable
attorneys fees and expenses incurred in advising, structuring, drafting, negotiating, reviewing,
administering, amending, terminating, enforcing, defending or concerning the Loan Documents,
irrespective of whether suit is brought, and monitoring and representing Lender’s interests in
connection with the Case; provided, however, that, except for any costs and
expenses incurred by Lender in connection with the enforcement of its rights under this Agreement
and the other Loan Documents upon the occurrence and during the continuance of an Event of Default,
“Lender Expenses” shall not exceed $25,000 in the aggregate.

          “Lien” means (a) any mortgage, deed of trust, pledge, hypothecation, security
interest, encumbrance, lien or charge of any kind whatsoever, (b) the interest of a vendor or a
lessor under any conditional sale, capital lease or other title retention agreement (or any
financing lease having substantially the same economic effect as any of the foregoing), (c) in the
case of securities, any purchase option, call or similar right of a third party with respect to
such securities and (d) any other arrangement having the effect of providing security.

          “Loan” has the meaning set forth in Section 2.1(a) of this Agreement.

          “Loan Documents” means, collectively, this Agreement, the Note, any other note or
notes executed by Borrower and payable to Lender in connection with the loan(s) extended under this
Agreement, any other written agreement or instrument entered into in connection with this
Agreement, the Bankruptcy Order(s), and any related order of findings issued by the Bankruptcy
Court, but excluding the Existing Agreements and the Strategic Alliance Agreement.

          “Material Adverse Effect” means (a) a material adverse change in, or effect upon, the
operations, business, properties, liabilities (actual or contingent), or financial condition of

-6-

 

Borrower taken as a whole; (b) a material impairment of the rights and remedies of Lender
under any Loan Document, or of the ability of Borrower to perform its obligations under any Loan
Document to which it is a party; or (c) a material impairment upon the legality, validity, binding
effect or enforceability against Borrower of any Loan Document to which it is a party;
provided, however, that the filing of the Case and/or the events leading thereto or
resulting therefrom shall not constitute a Material Adverse Effect.

          “Maturity Date” means the earliest of: (a) five (5) months after the Interim Order
Entry Date; (b) the effectiveness of a plan of reorganization or liquidation (a “Plan”)
that is confirmed pursuant to an order entered by the Bankruptcy Court or any other court having
jurisdiction in the Chapter 11 Case, but in no event shall such date be later than the effective
date of such Plan; (c) the date of the voluntary termination of the commitments under the Loan by
Borrower; or (d) the acceleration of the Loan upon an Event of Default.

          “Maximum Amount” means an amount equal to One Million Five Hundred Thousand Dollars
($1,500,000.00).

          “Monthly Budgeted Disbursements” means, with respect to any calendar month period, the
aggregate amount of projected cash disbursements by Borrower set forth in the Budget with respect
to such calendar month period.

          “Negotiable Collateral” means all of Borrower’s now owned and hereafter acquired
right, title, and interest with respect to letters of credit, letter of credit rights, instruments,
promissory notes, drafts, documents and chattel paper (including electronic chattel paper and
tangible chattel paper), and any and all supporting obligations in respect thereof.

          “Net Cash Proceeds” means, in connection with any Disposition of any property, debt
financing or equity financing, the proceeds thereof in the form of cash or cash equivalents
(including any such proceeds received by way of deferred payment of principal pursuant to a note or
installment receivable or purchase price adjustment receivable or otherwise, but only as and when
received), net of any related direct costs, sale and other transaction taxes and amounts
retained/paid to parties having superior rights actually incurred in connection therewith.

          “Non-Default Interest Rate” means a rate equal to Prime Rate plus one half percent
(0.5%) per annum.

          “Note” means a promissory note to be delivered by Borrower, as maker, to Lender, as
payee, in the form of Exhibit 3 hereto.

          “Notice of Borrowing” means a notice and certification in the form of Exhibit
4 hereto delivered by Borrower to Lender at least two (2) Business Days prior to each Advance
under this Agreement.

          “Obligations” means all loans, Advances, debts, principal, interest, fees, expenses,
amounts and contingent reimbursement obligations owing to Lender under this Agreement, the other
Loan Documents or pursuant to any other arrangement between Lender and Borrower relating to the
Loan Documents, and irrespective of whether for the payment of money, whether direct or indirect,
absolute or contingent, due or to become due, now existing or hereafter arising,

-7-

 

and including all interest not paid when due and all Lender Expenses that Borrower is required
to pay or reimburse by the Loan Documents, by law, or otherwise.

          “Official Creditors’ Committee” means the official committee of unsecured creditors in
the Case appointed by the United States Trustee.

          “Permitted Liens” has the meaning set forth in Section 5.1 hereof.

          “Person” means and includes natural persons, corporations, limited liability
companies, limited partnerships, general partnerships, joint ventures, trusts, land trusts,
business trusts, statutory trusts or other organizations, irrespective of whether they are legal
entities, and governments and agencies and political subdivisions thereof.

          “Petition” means the voluntary petition filed by Borrower under Chapter 11 of the
Bankruptcy Code commencing the Case.

          “Petition Date” has the meaning set forth in the Recitals to this Agreement.

          “Prepayment Date” means the date that is thirty (30) days after the entry of the
Interim Order by the Bankruptcy Court if the Final Order has not been entered by the Bankruptcy
Court prior to the expiration of such thirty (30) day period.

          “Pre-Petition Payment” means a payment (by way of adequate protection or otherwise) of
principal or interest or otherwise on account of any pre-petition or pre-filing Indebtedness or
trade payables or other pre-petition or pre-filing claims against Borrower.

          “Prime Rate” means the per annum rate of interest established from time to time by
Bank of America as its Prime Rate.

          “Prior Liens” shall have the meaning given such term in Section 5.4(a)(iv).

          “Prior Period” means, as of any date of determination, the preceding one month
calendar period.

          “Real Property” means any estates or interests in real property now owned or hereafter
acquired by Borrower and the improvements thereto.

          “Strategic Alliance Agreement” shall mean the Strategic Alliance Agreement, dated as
of July 22, 2005, between Borrower and Lender, as modified, in the form of Exhibit 5
hereto.

          “Subsequent Advance” has the meaning set forth in Section 2.1(a) of this Agreement.

          “Superpriority Claim” means a claim, pursuant to Section 364(c)(1) of the Bankruptcy
Code, against Borrower in the Case which is an administrative expense claim having priority over
any and all administrative expenses of the kind specified in Section 503(b) or 507(b) of the
Bankruptcy Code.

-8-

 

          “Termination Date” means the earliest to occur of (i) the Prepayment Date or (ii) the
Maturity Date.

          “UCC” means the Delaware Uniform Commercial Code or the Uniform Commercial Code as in
effect in any other jurisdiction as may be applicable to the perfection or effect of perfection or
non-perfection of Lender’s security interest in any Collateral or the enforcement of Lender’s
rights in Collateral, each as in effect from time to time.

          “United States Trustee” means the United States Trustee for the District of Delaware.

          “Variance Report” means a report to be delivered by Borrower to Lender on or before
the 10th day of each calendar month in form and substance satisfactory to Lender, on a
monthly basis (commencing on or before October 10, 2009) containing without limitation, the
following: (i) the actual cash receipts and disbursements on a line item basis for the Prior
Period; (ii) the actual cash receipts and disbursements on a cumulative basis since the Petition
Date; (iii) the dollar amount and percentage variance of such amounts from those set forth in the
Budget for such Prior Period; and (iv) a narrative analysis of Borrower’s performance for the Prior
Period and the variance set forth in clause (iii) above.

          “Voidable Transfer” has the meaning set forth in Section 14.11 hereof.

          1.2 UCC. Any terms used in this Agreement that are defined in the UCC shall be construed and
defined as set forth in the UCC unless otherwise defined herein.

          1.3 Construction. Unless the context of this Agreement clearly requires otherwise, references
to the plural include the singular, references to the singular include the plural, the term
“including” is not limiting, and the term “or” has, except where otherwise indicated, the inclusive
meaning represented by the phrase “and/or.” The words “hereof,” “herein,” “hereby,” “hereunder,”
and similar terms in this Agreement refer to this Agreement as a whole and not to any particular
provision of this Agreement. Section, subsection, clause, schedule, and exhibit references are to
this Agreement unless otherwise specified. Any reference in this Agreement or in the Loan
Documents to this Agreement or any of the Loan Documents shall include all alterations, amendments,
changes, extensions, modifications, renewals, replacements, substitutions and supplements thereto
and thereof, as applicable.

          1.4 Exhibits. All of the exhibits attached to this Agreement shall be deemed incorporated
herein by reference.

SECTION 2

LOAN AND TERMS OF PAYMENT

          2.1 Advances.

               (a) Provided that no Event of Default has occurred and is continuing and subject to the terms
and conditions of this Agreement, Lender agrees to loan to Borrower up to the Maximum Amount (the
“Loan”). The Loan will be made in multiple advances. The first advance shall be made
within three (3) Business Days following the Interim Order Entry Date in

-9-

 

an amount provided in the Budget (the “Initial Advance”). Subsequent advances
(“Subsequent Advances” and each of the Subsequent Advances and the Initial Advance, an
“Advance”) shall be made on a bi-weekly basis but no more frequently than two Advances per
month in the amounts set forth in the Budget. If the date of an Advance is not on a Business Day,
such Advance shall be made on the immediately following Business Day.

               (b) Borrower shall deliver a fully completed and duly executed Notice of Borrowing to Lender
at least two (2) Business Days prior to each Advance under this Agreement.

               (c) Borrower shall use the Advances provided under this Agreement solely for the purpose of
making disbursements consistent with the Budget or any variation thereto approved by written
consent of Lender in its sole and absolute discretion.

               (d) Any Advance of Loan proceeds made by Lender hereunder shall be credited against the
Maximum Amount and, for purposes of calculating the Maximum Amount, no Advance shall be deemed to
have been reduced by the amount of any repayment of any Obligation hereunder. No Advance, once
repaid, may be re-borrowed hereunder.

               (e) Lender shall have no obligation to make any Advances following the Termination Date.

               (f) Lender shall have no obligation to make Advances hereunder to the extent that such
Advances would cause the principal amount of the loan to exceed the Maximum Amount.

               (g) Borrower agrees to establish and maintain a single designated deposit account for the
purpose of receiving the proceeds of the Advances requested by Borrower and made by Lender
hereunder. Unless otherwise agreed by Lender and Borrower, any Advance requested by Borrower and
made by Lender hereunder shall be made by wire transfer to such designated deposit account.

          2.2 Overadvances. If, at any time or for any reason, the principal amount of the loan owed by
Borrower to Lender pursuant to Section 2.1 is greater than the Maximum Amount, Borrower
immediately shall pay to Lender, in cash, the amount of such excess.

          2.3 Interest: Rates, Payments, and Calculations.

               (a) Interest Rate. Unless an Event of Default has occurred and is continuing, all
interest bearing Obligations shall bear interest at the Non-Default Interest Rate.

               (b) Default Rate. Upon the occurrence and during the continuance of an Event of
Default, all interest bearing Obligations and, to the extent past due, all other Obligations shall
bear interest at the Default Interest Rate.

               (c) Payments. Interest and fees hereunder (including Lender Expenses and fees) shall
be earned, in full, when such interest or fee is incurred, and due and payable, in full, in
accordance with the Budget or as set forth herein.

-10-

 

               (d) Compounding. Any interest not paid when due shall be compounded monthly by
becoming a part of the Obligations, and, as part of the Obligations, such interest thereafter shall
bear interest at the rate then applicable hereunder.

               (e) Intent to Limit Charges to Maximum Lawful Rate. In no event shall the interest
rate or rates payable under this Agreement, plus any other amounts paid in connection herewith,
exceed the highest rate permissible under any law that a court of competent jurisdiction shall, in
a final determination, deem applicable. Borrower and Lender, in executing this Agreement, intend
legally to agree upon the rate or rates of interest and manner of payment stated herein;
provided, however, that, anything contained herein to the contrary notwithstanding,
if such rate or rates of interest or manner of payment exceeds the maximum allowable under
applicable law, then, ipso facto as of the date of this Agreement, Borrower is and
shall be liable only for the payment of such maximum as allowed by law, and payment received from
Borrower in excess of such legal maximum, whenever received, shall be applied to reduce the
principal balance of the Obligations to the extent of such excess.

          2.4 Repayment of Obligations.

               (a) Termination Date Payment. Borrower hereby unconditionally promises to pay to
Lender the full amount of the Obligations, including all outstanding principal and accrued interest
under the Note, on the Termination Date.

               (b) Optional Prepayments. Borrower may at any time and from time to time prepay the
Note, in full or in part, without premium or penalty, upon irrevocable written notice delivered to
Lender at least three (3) Business Days prior to the date of prepayment.

               (c) Mandatory Prepayments. The Obligations will be required to be prepaid by
Borrower, without penalty or premium, within seven (7) calendar days of receipt by Borrower, in an
amount equal to 100% of the Net Cash Proceeds as a result of any: (a) asset Dispositions (other
than Dispositions permitted under Section 7.3); (b) debt or equity issued for money borrowed or
received; (c) casualty insurance and/or condemnation receipts; and/or (d) payments received
respecting any tax refunds, deposits, escrows and litigation settlements; provided, however, that
all mandatory prepayments shall be subject to and net of the Carve-Out.

          2.5 Crediting Payments; Application of Collections. The receipt by Lender of any wire
transfer of funds, check, or other item of payment sent by or for the account of Borrower shall be
applied to provisionally reduce the Obligations, but shall not be considered a payment on account
unless such wire transfer is of immediately available federal funds and is made to the appropriate
deposit account of Lender or unless and until such check or other item of payment is honored when
presented for payment. Should any check or item of payment not be honored when presented for
payment, then Borrower shall be deemed not to have made such payment, and interest shall be
recalculated accordingly. Anything to the contrary contained herein notwithstanding, any wire
transfer, check, or other item of payment shall be deemed received by Lender only if it is received
into Lender’s account on or before 2:00 p.m. prevailing time in New York, New York. If any wire
transfer, check, or other item of payment is received into Lender’s account after 2:00 p.m., it
shall be deemed to have been received by Lender as of the opening of business on the immediately
following Business Day.

-11-

 

SECTION 3

CONDITIONS; TERM

          3.1 Conditions Precedent to Initial Advance. The obligation of Lender to make the Initial
Advance to Borrower under this Agreement is subject to the fulfillment (or waiver in accordance
with Section 14.8) of each of the following conditions:

               (a) Lender shall have received a certificate from an Authorized Officer of Borrower attesting
to the resolutions of Borrower authorizing Borrower’s execution and delivery of this Agreement, the
Note and the other Loan Documents, if any, to which Borrower is a party.

               (b) Lender shall have received a duly executed Note from Borrower.

               (c) All other documents and legal matters relating to the transactions contemplated by this
Agreement shall have been delivered or executed or recorded, as applicable, and shall be in form
and substance satisfactory to Lender and its counsel.

               (d) Lender shall have received satisfactory evidence of the entry by the Bankruptcy Court of
the Interim Order, which Interim Order (i) shall have been entered upon an application or motion
of Borrower satisfactory in form and substance to Lender, on such prior notice to such parties as
may in each case be satisfactory to Lender, (ii) shall be in form and substance satisfactory to
Lender, (iii) shall be in full force and effect, and (iv) shall not have been vacated, stayed,
reversed, modified or amended in any respect; and, if the Interim Order is the subject of a pending
appeal in any respect, neither the making of such Loans nor the performance by Borrower of any of
its respective obligations hereunder or under the Loan Documents or under any other instrument or
agreement referred to herein shall be the subject of a presently effective stay pending appeal.

               (e) Borrower shall have assumed the Strategic Alliance Agreement and shall have obtained an
order from the Bankruptcy Court approving the assumption of, and any modifications to, the
Strategic Alliance Agreement in form and substance satisfactory to Lender.

               (f) Prior to or concurrently with the Initial Advance, Borrower shall have paid to Lender the
then unpaid balance of all accrued and unpaid fees due under and pursuant to this Agreement and the
fees and expenses of counsel to the Lender as to which invoices have been issued.

               (g) All corporate and judicial proceedings and all instruments and agreements in connection
with the transactions among Borrower and Lender contemplated by this Agreement shall be
satisfactory in form and substance to Lender, and Lender shall have received all information and
copies of all documents and papers, including records of corporate and judicial proceedings, which
Lender may have reasonably requested in connection therewith, such documents and papers where
appropriate to be certified by proper corporate, governmental or judicial authorities.

-12-

 

               (h) Borrower shall have granted Lender access to and the right to inspect all reports, audits
and other internal information of Borrower relating to environmental matters, and any third party
verification of certain matters relating to compliance with Environmental Laws reasonably requested
by Lender, and Lender shall be reasonably satisfied that Borrower are in compliance in all material
respects with all applicable Environmental Laws and Environmental Permits and Borrower has made
adequate provision for the costs of maintaining such compliance.

               (i) Lender shall have received UCC and other customary searches (including tax liens and
judgments) conducted in the jurisdictions in which Borrower conducts business (dated as of a date
reasonably satisfactory to Lender), reflecting the absence of Liens and encumbrances on the assets
of Borrower other than Liens granted or permitted under the Existing Agreements, and such other
Liens as may be reasonably satisfactory to Lender.

               (j) Borrower shall have furnished to Lender the Budget, in form and substance acceptable to
Lender in accordance with Section 6.9 of this Agreement, and such Budget shall have been prepared
in good faith based upon assumptions which Borrower believes to be reasonable assumptions. To the
knowledge of Borrower, (i) the Budget sets forth all potential expenses of Borrower in connection
with the Case and (ii) no facts exist that (individually or in the aggregate) would be reasonably
expected to result in any material change in the Budget.

          3.2 Conditions Precedent to Each Advance. The obligation of Lender to make each Advance,
whether an Initial Advance or a Subsequent Advance, is subject to the satisfaction (or waiver in
accordance with Section 14.7) of the following conditions precedent:

               (a) Lender shall have received a notice with respect to such borrowing, as required by Section
2.1(b).

               (b) All representations and warranties contained in this Agreement and the other Loan
Documents shall be true and correct in all material respects on and as of the date of such Advance,
as though made on and as of such date (except to the extent that such representations and
warranties relate solely to an earlier date, in which case the same shall remain true and correct
as of such date);

               (c) On the date of each such Advance, no Event of Default which upon notice or lapse of time
or both would constitute an Event of Default shall have occurred and be continuing (each, a
“Default”).

               (d) The Interim Order shall be in full force and effect and shall not have been stayed,
reversed, modified or amended in any respect without the prior written consent of the Lender. No
later than thirty (30) days after the entry of the Interim Order, the Final Order shall have been
entered by the Bankruptcy Court and shall be in full force and effect, and shall not have been
vacated, stayed, reversed, modified or amended in any respect without the prior written consent of
the Lender. If either the Interim Order or the Final Order is the subject of a pending appeal in
any respect, neither the making of the Loans nor the performance by the

-13-

 

Borrower of any of their respective obligations under any of the Loan Documents shall be the
subject of a presently effective stay pending appeal.

               (e) Prior to or concurrently with the requested Advance, Borrower shall have paid to Lender
the then unpaid balance of all accrued and unpaid fees due under and pursuant to this Agreement and
the Bankruptcy Orders and fees and expenses of counsel to Lender as to which invoices have been
issued.

          3.3 Term. The term during which Lender will make Advances of Loan proceeds to Borrower shall,
subject to all of the other terms and conditions of this Agreement, commence with the advancement
of the Initial Advance and shall continue until the Termination Date.

          3.4 Effect of Termination. On the Termination Date, all Obligations shall become due and
payable immediately by Borrower to Lender without notice or demand. No termination of the period
for making Advances hereunder, however, shall relieve or discharge Borrower of Borrower’s duties,
Obligations, or covenants hereunder, and Lender’s continuing security interests in and liens upon
the Collateral (and all other rights of Lender under the Loan Documents) shall remain in effect
until all Obligations have been fully and finally discharged.

SECTION 4

CREATION OF SECURITY INTERESTS, LIENS

          4.1 Grant of Security Interests and Liens. Borrower hereby grants to Lender continuing first
priority security interests in and liens upon all currently existing and hereafter acquired
Collateral (excluding Avoidance Actions) in order to secure prompt repayment of any and all
Obligations and in order to secure prompt performance by Borrower of its covenants and duties under
the Loan Documents (the “DIP Liens”). Lender’s security interests in and liens upon the
Collateral shall attach to all Collateral without further act on the part of Lender or Borrower.
The security interests and liens granted herein are in addition to, and not in limitation of, any
and all security interests in and liens upon the Collateral granted to Lender pursuant to the terms
of the Bankruptcy Order(s). Notwithstanding anything to the contrary contained herein, Lender’s
security interests in the Collateral are subordinate to any Carve-Out expenses; provided,
that no portion of the Carve-Out may be utilized to fund prosecution or assertion of any claims
against Lender (it being understood that, in the event of the liquidation of Borrower’s estate, the
amount of the Carve-Out shall be funded into a segregated account prior to the making of
distributions), including but not limited to: (a) interferences with enforcement of Lender’s rights
against any Collateral after any Event of Default under the Loan Documents; (b) objection to or
contesting the validity, extent, amount, perfection, priority, or enforceability of the obligations
under the Loan Documents, and the DIP Liens; (c) objection to or contesting the validity, extent,
amount, perfection, priority, or enforceability of the obligations, security interests and liens
created under that certain Credit and Patent Security Agreement, dated July 22, 2005, between
Borrower and Lender (“Lender Prepetition Liens”); and (d) any assertion or prosecution of
any claim against Lender or the Collateral, including any claim under Section 506(c) of the
Bankruptcy Code.

-14-

 

          4.2 Negotiable Collateral. In the event that any Collateral, including proceeds, is evidenced
by or consists of Negotiable Collateral, Borrower shall, immediately upon the request of Lender,
endorse and assign such Negotiable Collateral to Lender and deliver physical possession of such
Negotiable Collateral to Lender.

          4.3 Delivery of Additional Documentation Required. Borrower shall at any time upon the
request of Lender execute and deliver to Lender all financing statements, continuation financing
statements, fixture filings, security agreements, chattel mortgages, lease assignments and/or lease
mortgages, real property mortgages, pledges, assignments, endorsements of certificates of title,
applications for title, affidavits, reports, notices, consents, schedules of accounts, letters of
authority, and all other documents that Lender may reasonably request, in form satisfactory to
Lender, to perfect and continue perfected Lender’s security interests in and liens upon the
Collateral, in order to fully consummate all of the transactions contemplated hereby and under the
other the Loan Documents, and if an Event of Default shall occur, to allow Lender to fully exercise
all of its rights in and liens upon the Collateral. Nothing herein shall limit the effect of the
Bankruptcy Order(s).

          4.4 Power of Attorney. Subject to Lender obtaining relief from stay from the Bankruptcy Court
to exercise the rights described herein to the extent necessary, Borrower hereby irrevocably makes,
constitutes, and appoints Lender (and any agents designated by Lender) as Borrower’s true and
lawful attorney, with power to: (a) if Borrower refuses to, or fails timely to execute and deliver
any of the documents described in Section 4.3, sign the name of Borrower on any of the
documents described in Section 4.3 or on any other similar documents to be executed,
recorded, or filed in order to perfect or continue the perfection of Lender’s security interests in
and liens upon the Collateral; (b) at any time that an Event of Default has occurred and is
continuing, sign Borrower’s name on any invoice or bill of lading relating to any account, drafts
against account debtors, schedules and assignments of accounts, verifications of accounts, and
notices to account debtors; (c) send requests for verification of accounts; (d) prosecute, maintain
and protect Borrower’s Intellectual Property; (e) at any time that an Event of Default has occurred
and is continuing, endorse Borrower’s name on any checks, notices, acceptances, money orders,
drafts, or other item of payment or security that may come into Lender’s possession; (f) at any
time that an Event of Default has occurred and is continuing, assemble and dispose of the
Collateral (including Borrower’s Intellectual Property), by sale, license or otherwise and to
execute any and all necessary documents in connection therewith; (g) at any time that an Event of
Default has occurred and is continuing, notify the post office authorities to change the address
for delivery of Borrower’s mail to an address designated by Lender, to receive and open all mail
addressed to Borrower, and to retain all mail relating to the Collateral or the inventory and
forward all other mail to Borrower; (h) at any time that an Event of Default has occurred and is
continuing, make, settle, and adjust all claims under Borrower’s policies of insurance and make all
determinations and decisions with respect to such policies of insurance; (i) at any time that an
Event of Default has occurred and is continuing, settle and adjust disputes and claims respecting
the accounts directly with account debtors, for amounts and upon terms which Lender determines to
be reasonable, and Lender may cause to be executed and delivered any documents and releases which
Lender determines to be necessary; and (j) at any time that an Event of Default has occurred and is
continuing and Lender is pursuing remedies under Section 9.1, if Borrower refuses to, or fails
timely to execute and deliver any of the necessary or appropriate documents, cause Borrower’s
clearance or standing as registrant,

-15-

 

petitioner and/or applicant and/or other status as Borrower may obtain from the FDA for the
OVA-1 test to be assigned and/or transferred to Lender. The appointment of Lender as Borrower’s
attorney, and each and every one of Lender’s rights and powers, being coupled with an interest, is
irrevocable until all of the Obligations have been fully and finally repaid and performed and
Lender’s obligation to extend credit hereunder is terminated.

          4.5 Right to Inspect. Lender shall have the right, from time to time hereafter, to inspect
Borrower’s Books and to inspect the Collateral in order to verify Borrower’s financial condition or
the amount, quality, value, condition of, or any other matter relating to, the Collateral. Lender
shall give Borrower reasonable notice before conducting any such inspection, which notice shall be
no less than twenty-four (24) hours.

          4.6 Lender Prepetition Liens and Existing Indebtedness. Lender’s Prepetition Liens are hereby
deemed valid, enforceable, perfected, and senior in priority, scope and extent as of the Petition
Date as granted under that certain Credit and Patent Security Agreement, dated July 22, 2005,
between Borrower and Lender. Lender’s Existing Indebtedness is hereby deemed an allowed secured
claim in the Case.

SECTION 5

REPRESENTATIONS AND WARRANTIES

          Borrower represents and warrants to Lender as follows:

          5.1 No Prior Encumbrances. Borrower has good and indefeasible title to the Collateral,
subject only to the following interests existing as of the Petition Date (which in the aggregate
shall be construed as “Permitted Liens”): (a) liens for taxes or other governmental
charges not at the time delinquent or thereafter payable without penalty or being contested in good
faith; (b) liens of carriers, warehousemen, mechanics, materialmen, vendors, and landlords incurred
in the ordinary course of business for sums not overdue, payable without penalty or being contested
in good faith; (c) deposits under workers’ compensation, unemployment insurance and social security
laws or to secure the performance of bids, tenders, contracts or leases, or to secure statutory
obligations of surety or appeal bonds or to secure indemnity, performance or other similar bonds in
the ordinary course of business; (d) easements, reservations, rights of way, restrictions, minor
defects or irregularities in title and other similar charges or encumbrances affecting real
property in a manner not materially or adversely affecting the value or use of such property; (e)
liens securing obligations under a capital lease if such liens do not extend to property other than
the property leased under such capital lease, and any accessions, replacements, substitutions and
proceeds (including insurance proceeds) thereof or thereto; (f) liens upon any equipment to secure
the purchase price of such equipment or Indebtedness incurred solely for the purpose of financing
the acquisition of such equipment, so long as such lien extends only to the equipment financed, and
any accessions, replacements, substitutions and proceeds (including insurance proceeds) thereof or
thereto; and (g) liens in favor of Lender.

          5.2 Due Organization and Qualification. Borrower is duly organized and existing and in good
standing under the laws of the state of its formation and qualified and licensed to do business in,
and in good standing in, any state where the failure to be so licensed

-16-

 

or qualified could reasonably be expected to have a material adverse effect on the value of
the Collateral to Lender.

          5.3 Due Authorization; No Conflict. The execution, delivery, and performance of the Loan
Documents are within Borrower’s corporate powers, have been duly authorized, and are not in
conflict with nor constitute a breach of any provision contained in Borrower’s certificate of
incorporation, bylaws, or other organizational documents, as in effect on the date hereof or the
date of any Advance of Loan proceeds by Lender hereunder, nor will they constitute an event of
default under any material agreement to which Borrower is a party or by which its properties or
assets may be bound.

          5.4 Priority and Liens.

               (a) Upon the entry of the Interim Order (and the Final Order, as applicable), the Obligations:

          (i) shall at all times constitute a Superpriority Claim in the Case;

          (ii) pursuant to Section 364(c)(2) of the Bankruptcy Code, shall at all times
be secured by a perfected first priority Lien on all property of Borrower’s estate
in the Case that as of the Petition Date were not subject to valid, perfected and
non-avoidable Liens, including, without limitation, all present and future accounts
receivable, inventory, general intangibles, chattel paper, real property,
leaseholds, fixtures, machinery and equipment, deposit accounts, patents,
copyrights, trademarks, trade names, rights under license agreements and other
intellectual property, capital stock of any Subsidiaries of Borrower or any
Guarantors;

          (iii) pursuant to Section 364(c)(3) of the Bankruptcy Code, shall be secured by
a perfected junior Lien upon all property of Borrower (other than the property that
as of the Petition Date were subject to existing Liens that secured the obligations
of Borrower under the Existing Agreements and Liens that are junior to such existing
Liens under the Existing Agreement, as to which the Lien in favor of Lender will be
as described in clause (iv) of this sentence) that is subject to valid, perfected
and non-avoidable Liens in existence on the Petition Date or to valid Liens in
existence as of the Petition Date that are perfected subsequent to the Petition Date
as permitted by Section 546(b) of the Bankruptcy Code or to Permitted Liens, junior
to such valid, perfected and non-avoidable Liens, valid and subsequently perfected
Liens or Permitted Liens;

          (iv) pursuant to Section 364(d)(1) of the Bankruptcy Code, shall be secured by
a perfected first priority, senior priming Lien on all of the tangible and
intangible property of Borrower (including without limitation, such property of
Borrower referred to in clause (ii) of this sentence and the proceeds thereof) that
as of the Petition Date was subject to existing Liens that secured Borrower’s
pre-petition or pre-filing Indebtedness under the Existing Agreements

-17-

 

and Liens that are junior to such existing Liens (but subject to any Liens in
existence as of the Petition Date to which the Liens being primed hereby are subject
or become subject subsequent to the Petition Date as permitted by Section 546(b) of
the Bankruptcy Code (such Liens to which the primed Liens are subject, collectively
the “Prior Liens”)) and any Liens granted after the Petition Date to provide
adequate protection in respect of the Existing Agreements, senior to all of such
Liens; provided, that the Liens and claims granted to Lender in the
preceding clauses (i) to (iv) shall be subject to (w) Avoidance Actions (x) in the
event of the occurrence and during the continuance of an Event of Default or an
event that would constitute an Event of Default with the giving of notice or lapse
of time or both, the payment of the collective allowed and unpaid professional fees
and disbursements incurred by Borrower and the Official Creditors Committee in the
Case in an aggregate amount not to exceed $150,000.00, but in each case, solely to
the extent such allowed and unpaid professional fees are incurred in accordance with
the Budget (plus all unpaid professional fees and disbursements incurred prior to
the occurrence of an Event of Default or an event that would constitute an Event of
Default with the giving of notice or lapse of time or both to the extent such
professional fees and disbursements are incurred in accordance with the Budget and
are allowed by the Bankruptcy Court at any time), (y) allowed Incentive Plan
Payments to Incentive Plan Participants in an aggregate amount not to exceed
$150,000.00, and (z) the payment of unpaid fees pursuant to 28 U.S.C. § 1930(a)(6)
and to the Clerk of the Bankruptcy Court ((w),(x),(y) and (z), collectively, the
“Carve-Out”); provided, further, that no portion of the
Carve-Out may be utilized to fund prosecution or assertion of any claims against
Lender (it being understood that, in the event of the liquidation of Borrower’s
estate, the amount of the Carve-Out shall be funded into a segregated account prior
to the making of distributions).

               (b) Upon the entry of the Interim Order (and the Final Order, as applicable), the provisions
of the Loan Documents and the Bankruptcy Orders are effective to create in favor of Lender a legal,
valid, perfected and enforceable lien in all right, title and interest of Borrower in the
Collateral described herein, therein and in the Bankruptcy Orders (having the priority provided for
herein, therein and in the Bankruptcy Orders).

          5.5 Further Assurances. Borrower agrees that it will, at its own expense, promptly execute
and deliver to Lender, or cause to be executed and delivered to Lender, on reasonable request by
Lender, all such other and further documents, agreements and instruments necessary to satisfy the
obligations of Borrower under the Loan Documents or under any of the documents arising from the
Loan Documents, to effect any registrations or filings reasonably required by Lender or to use
commercially reasonable efforts to obtain any consents reasonably required by Lender.

          5.6 Information Regarding Collateral. Borrower will furnish to Lender prompt written notice
of any change (a) in Borrower’s corporate name (including, without limitation, any additional
corporate name), (b) in the jurisdiction of incorporation or organization of Borrower, (c) in
Borrower’s organizational identification number or (d) in the jurisdiction(s) in which Borrower
chief executive office and domicile is (are) located. Borrower agrees not to

-18-

 

effect or permit any change (or addition) referred to in the preceding sentence unless all
filings have been made under the UCC or otherwise that are required in order for Lender to continue
at all times following such change to have a valid, legal and perfected security interest in all
the Collateral (or Borrower shall have furnished to Lender any such documentation necessary to
effectuate the foregoing).

          5.7 Reliance by Lender; Cumulative. Each warranty and representation contained in this
Agreement automatically shall be deemed repeated with each Advance in a manner consistent with
Section 3.2(b) and shall be conclusively presumed to have been relied upon by Lender regardless of
any investigation made or information possessed by Lender. The warranties and representations set
forth herein shall be cumulative and in addition to any and all other warranties and
representations that Borrower now or hereafter shall give, or cause to be given, to Lender pursuant
to the terms and conditions of any Loan Document.

          5.8 Covenants Relating to Intellectual Property Collateral. The covenants in Sections 5(j),
5(k) and 5(l) contained in the Patent Security Agreement by and between Quest Diagnostics
Incorporated and Ciphergen Biosystems, Inc. dated July 22, 2005 are hereby incorporated by
reference.

SECTION 6

AFFIRMATIVE COVENANTS

          Borrower covenants and agrees that, so long as any credit hereunder shall be available and
until payment in full of the Obligations, and unless Lender shall otherwise consent in writing,
Borrower shall do all of the following:

          6.1 Maintenance of Property. Borrower shall maintain and keep the Collateral in good
condition, repair and working order, ordinary wear and tear excepted, and will not commit or permit
any waste or unreasonable depreciation. Borrower will not alter, remove, or demolish any
Collateral without Lender’s prior written consent, except as may be required by law or in the
ordinary course of business or with respect to Collateral that is worn out, obsolete or of
inconsequential value.

          6.2 Books and Records; Inspection. Borrower shall keep proper books of records and account in
which full, complete and correct entries in conformity with all material requirements of law shall
be made of all dealings and transactions in relation to its business and activities and shall
permit representatives of Lender, upon reasonable notice to visit and inspect any of its properties
and examine and, to the extent reasonable, make abstracts from and copies of any of its books and
records, including, without limitation, in connection with any appraisal.

          6.3 Notices. Borrower shall give prompt notice to Lender of:

               (a) The occurrence of any Event of Default or any event that, with the passage of time or the
giving of notice, will constitute an Event of Default;

               (b) Any litigation or proceeding affecting Borrower (i) in which the amount involved is
$100,000 or more, whether or not covered by insurance, (ii) in which

-19-

 

injunctive or similar relief is sought, (iii) that directly relates to any Loan Document or
(iv) that could reasonably be expected to have a Material Adverse Effect;

               (c) The receipt by Borrower of notice of violation of any environmental law, rule or
regulation (i) that is reasonably likely to result in costs to correct or remedy the violation,
fines or penalties of $100,000 or more or (ii) that could reasonably be expected to have a Material
Adverse Effect; and

               (d) Any development or event that has had or could reasonably be expected to have a Material
Adverse Effect on (a) the business, property, operations, condition (financial or otherwise),
performance or prospects of Borrower, (b) the value or condition of the Collateral or (c) the
validity or enforceability of this Agreement or any of the other Loan Documents or the rights or
remedies of Lender hereunder or thereunder.

          6.4 Taxes. Except as otherwise provided by a confirmed plan of reorganization or liquidation,
all assessments and taxes (other than taxes or assessments that are subject of a bona fide
protest), whether real, personal, or otherwise, due or payable by, or imposed, levied, or assessed
against Borrower or its property have been paid, and shall hereafter be paid in full, before
delinquency or before the expiration of any extension period, in each case, to the extent required
under the Bankruptcy Code.

          6.5 Insurance.

               (a) Borrower, at its expense, shall keep the Collateral insured against loss or damage by
fire, theft, explosion, and all other hazards and risks, and in such amounts as have been
historically maintained. Borrower also shall maintain liability insurance relating to Borrower’s
ownership and use of the Collateral, as well as insurance against larceny, embezzlement, and
criminal misappropriation in such amounts as have been historically maintained.

               (b) All such policies of insurance shall be in such form, with such companies, and in such
amounts as have been historically maintained. Upon request from Lender, Borrower shall deliver to
Lender certified copies of such policies of insurance and evidence of the payment of all premiums
therefor. All proceeds payable under any policy of insurance in respect of the Collateral shall be
payable to Lender to be applied on account of the Obligations.

          6.6 No Setoffs or Counterclaims. Except as otherwise provided by applicable law, all payments
hereunder and under the other Loan Documents, if any, made by or on behalf of Borrower shall be
made without setoff or counterclaim and free and clear of, and without deduction or withholding for
or on account of, any federal, state, or local taxes.

          6.7 Compliance with Laws. Except as otherwise provided under the Bankruptcy Code, Borrower
shall comply with the requirements of all applicable laws, rules, regulations, and orders of any
governmental authority, other than laws, rules, regulations, and orders the non-compliance with
which, individually or in the aggregate, would not have and could not reasonably be expected to
have a material adverse effect on the value of the Collateral to Lender.

-20-

 

          6.8 Budget.

               (a) The use of the Loans by Borrower under this Agreement and the other Loan Documents shall
be limited in accordance with the Budget. The Budget shall be updated, modified or supplemented by
Borrower from time to time, but in any event not less than on a monthly basis (with the delivery to
Lender on or before the 10th day of each calendar month). To the extent any such updated, modified
or supplemented Budget shall contain material variations from the Budget then most recently
delivered to Lender, such material variations shall be approved by Lender in its reasonable
discretion. Each Budget delivered to Lender shall be accompanied by such supporting documentation
as reasonably requested by Lender. Each Budget shall be certified by a Financial Officer of
Borrower and prepared in good faith based upon assumptions which Borrower believes to be reasonable
and satisfactory to Lender. For purposes of this Section 6.8(a), a “material variation” shall mean
a variation in the Budget in excess of the maximum variances then permitted under Section 7.7(b).

               (b) Borrower shall deliver to Lender on a monthly basis on or before the 10th day
of each calendar month a compliance certificate, in form and substance satisfactory to Lender,
signed by a Financial Officer of Borrower certifying that (x) Borrower is in compliance with the
covenants contained in Section 7.7 and (y) no Default has occurred or, if such a Default
has occurred, specifying the nature and extent thereof and any corrective action taken or proposed
to be taken with respect thereto, together with (A) a comparison for the Prior Period of the Actual
Receipts Amount and Actual Disbursement Amount for such Prior Period to the Budgeted Receipts
Amount and Budgeted Disbursement Amount for such Prior Period, respectively, and (B) a cumulative
comparison for the Cumulative Period of the Actual Receipts Amount and Actual Disbursement Amount
for such Cumulative Period to the Budgeted Receipts Amount and Budgeted Disbursement Amount for
such Cumulative Period, respectively, each of which shall be prepared by a Financial Officer of
Borrower as of the last day of the Prior Period or the Cumulative Period, as applicable, and shall
be in form and substance satisfactory to Lender in its sole discretion. Borrower shall also
deliver to Lender on a monthly basis, a Variance Report.

SECTION 7

NEGATIVE COVENANTS

          Borrower covenants and agrees that, so long as any credit hereunder shall be available and
until payment in full of the Obligations, and unless Lender shall otherwise consent in writing,
Borrower shall perform all covenants in this Section 7.

          7.1 Liens. Borrower shall not incur, create, assume or suffer to exist any Lien on any asset
of Borrower, now owned or hereafter acquired by Borrower, other than Permitted Liens.

          7.2 Indebtedness. Borrower shall not contract, create, incur, assume or suffer to exist any
Indebtedness, except for: (i) Indebtedness under the Loan Documents; (ii) Indebtedness incurred
prior to the Petition Date (including existing capitalized leases listed on Schedule G); (iii)
Indebtedness owed to any bank in respect of any overdrafts and related liabilities arising from
treasury, depository and cash management services or in connection with

-21-

 

any automated clearing house transfers of funds; provided, that, such Indebtedness is repaid
in full within two Business Days; and (iv) other Indebtedness of Borrower in an aggregate principal
amount not to exceed $50,000 at any time outstanding without the prior written consent of the
Lender.

          7.3 No Disposition. Borrower shall not Dispose of any assets, except for (i) sales of
inventory, fixtures and equipment in the ordinary course of business, (ii) Dispositions of surplus,
obsolete, negligible or uneconomical assets, without the prior written consent of Lender.

          7.4 Mergers/Asset Sales/Asset Purchases. Borrower shall not (i) become party to a merger or
consolidation, (ii) effect any sale of all or substantially all of Borrower’s assets, (iii)
purchase assets other than in the ordinary course of business, (iv) make any changes in the
corporate structure or identity of Borrower or (v) enter into any agreement to do any of the
foregoing without the prior written consent of Lender.

          7.5 No Subsidiaries. Borrower shall not form, or cause to be formed, any subsidiary of
Borrower.

          7.6 Conduct of Business. From and after the date hereof, Borrower shall not engage in any
business other than (i) business engaged in by Borrower on the date hereof and similar or related
businesses, and (ii) such other lines of business as may be consented to by Lender.

          7.7 Pre-Petition Claims / Budget Compliance.

               (a) Payment of Pre-Petition Claims. Borrower shall not make payments to creditors other than
Lender in respect of prepetition Indebtedness except for: (i) amounts previously approved by the
Bankruptcy Court and already paid or (ii) amounts approved by Lender in writing and by the
Bankruptcy Court, which in each case (described in clause (i) or (ii)) shall be included in any
Budget delivered under Section 6.9 of this Agreement.

               (b) Budget Compliance.

          (i) Unless permitted by Lender, Borrower shall not make any cash disbursement
if, after giving effect thereto: (A) the aggregate cash disbursements (other than
for Lender Expenses) by Borrower during each monthly period would exceed the product
of: (x) the aggregate of the Monthly Budgeted Disbursements for such monthly period
times (y) one hundred and ten percent (110%); or (B) the aggregate cash
disbursements (other than for Lender Expenses) by Borrower in respect of any one
line item contained in the Budget (for disbursements) during each monthly period
would exceed the greater of (1) the product of: (x) the aggregate of the
disbursements for such line item for such monthly period times (y) one hundred and
ten percent (110%), and (2) $1,000.

          (ii) Unless permitted by Lender, Borrower shall not permit the Actual Receipts
Amount for any monthly period shown in the Budget to be less than ninety percent
(90%) of the Budgeted Receipts Amount for such monthly period and (B) Borrower shall
not permit the cumulative aggregate of the Actual

-22-

 

Receipts Amount from September 1, 2009 through such monthly period to be less
than ninety percent (90%) of the Budgeted Receipts Amount from September 1, 2009
through such monthly period.

SECTION 8

EVENTS OF DEFAULT

          8.1 Events of Default. The happening of any of the following events and the continuance
thereof beyond the applicable grace period, if any, shall constitute an event of default under this
Agreement (each, an “Event of Default”):

               (a) any representation or warranty made by Borrower in this Agreement or in any Loan Document
or any statement or representation made in any report, financial statement, certificate or other
document furnished by Borrower to Lender under or in connection with this Agreement, taken as a
whole together with all such statements or representations, shall prove to have been false or
misleading in any material respect when made or delivered; or

               (b) any default shall be made in the payment of any (i) fees, interest on the Loans or other
amounts payable hereunder when due (other than amounts set forth in clause (ii) hereof) or (ii)
principal of the Loans, when and as the same shall become due and payable, whether at the due date
thereof (including the Prepayment Date) or at a date fixed for prepayment thereof or by
acceleration thereof or otherwise; or

               (c) any default shall be made by Borrower in the due observance or performance of any
covenant, condition or agreement contained in Section 7 hereof; or

               (d) Borrower shall fail to deliver the Budget or Variance Report when due and such default
shall continue unremedied for more than three Business Days; or

               (e) any default shall be made by Borrower in the due observance or performance of any other
covenant, condition or agreement to be observed or performed pursuant to the terms of this
Agreement, any of the Bankruptcy Orders or any of the other Loan Documents, including compliance
with the Budget, and such default shall continue unremedied for more than 10 days; or

               (f) the Case shall be dismissed or converted to a case under Chapter 7 of the Bankruptcy Code
or Borrower shall file a motion or other pleading seeking the dismissal of the Case under Section
1112 of the Bankruptcy Code or otherwise; a trustee under Chapter 7 or Chapter 11 of the Bankruptcy
Code, a responsible officer or an examiner with enlarged powers relating to the operation of the
business (powers beyond those set forth in Section 1106(a)(3) and (4) of the Bankruptcy Code) under
Section 1106(b) of the Bankruptcy Code shall be appointed in the Case and the order appointing such
trustee, responsible officer or examiner shall not be reversed or vacated within 30 days after the
entry thereof; or an application shall be filed by Borrower for the approval of any other
Superpriority Claim or other charge of any kind (other than the Carve-Out) in the Case which is
pari passu with or senior to the claims of Lender against Borrower hereunder, or
there shall arise or be granted any such pari passu or senior Superpriority Claim
or other charge of any kind; or

-23-

 

               (g) the Bankruptcy Court shall enter an order or orders granting relief from the automatic
stay applicable under Section 362 of the Bankruptcy Code, as may be extended from time to time,
granting relief, to the holder or holders of any security interest other than Lender to permit
foreclosure (or the granting of a deed in lieu of foreclosure or the like) or any other enforcement
of security on any assets of Borrower which have a value in excess of $50,000 in the aggregate; or

               (h) a Material Adverse Effect shall occur; or

               (i) any material provision of any Loan Document, the Strategic Alliance Agreement or Order
shall, for any reason, cease to be valid and binding on Borrower, or Borrower shall so assert in
any pleading filed in any court; or

               (j) an order of the Bankruptcy Court shall be entered reversing, staying for a period in
excess of 10 days, vacating or (without the written consent of the Lender) otherwise amending,
supplementing or modifying any of the Bankruptcy Orders in a manner that is adverse to Lender; or

               (k) any judgment or order in excess of $50,000 (exclusive of any judgment or order the amounts
of which are fully covered by insurance (less any applicable deductible) and as to which the
insurer has acknowledged its responsibility to cover such judgment or order) as to any
post-petition or post-filing obligation shall be rendered against Borrower and the enforcement
thereof shall not have been stayed; or

               (l) any non-monetary judgment or order with respect to a post-petition or post-filing event
shall be rendered against Borrower which has or could reasonably be expected to have a Material
Adverse Effect; or

               (m) except as permitted by the Bankruptcy Orders or as otherwise agreed to by Lender, Borrower
shall make any Pre-Petition Payment other than Pre-Petition Payments previously authorized by the
Bankruptcy Court; or

               (n) it shall be determined (whether by the Bankruptcy Court or by any other judicial or
administrative forum) that Borrower is liable for the payment of claims arising out of any failure
to comply (or to have complied) with applicable Environmental Laws and Environmental Permits, the
payment of which has or could reasonably be expected to have a Material Adverse Effect, and the
enforcement thereof shall not have been stayed; or

               (o) Borrower or is enjoined, restrained, or in any way prevented by court order from
continuing to conduct all or any material part of its business; or

               (p) Borrower shall file, support or fail to oppose a motion seeking, or the Bankruptcy Court
shall enter, an order in the Case (i) approving additional financing under Section 364(c) or (d) of
the Bankruptcy Code not otherwise permitted pursuant to this Agreement, (ii) granting any lien
(other than liens permitted the Bankruptcy Orders) upon or affecting any Collateral which are pari
passu or senior to the liens on the Collateral in favor of Lender, (iii) granting any claim
priority senior to or pari passu with the claims of Lender under the Loan Documents (other than to
the extent permitted pursuant to the terms of the Bankruptcy

-24-

 

Orders) or any other claim having priority over any or all administrative expenses of the kind
specified in Section 503(b) or Section 507(b) of the Bankruptcy Code, or (iv) granting any other
relief that is adverse to Lender’s interests under any Loan Document or its rights and remedies
hereunder or their interest in the Collateral; or

               (q) the Official Creditors’ Committee or any party in interest shall commence a suit, action
or contested matter against Lender, the Existing Lenders or affecting the Collateral, or joins or
actively supports a suit, action or contested matter against Lender, the Existing Lenders or that
affects the Collateral, that sets forth (a) a claim in excess of $50,000, (b) a claim or legal or
equitable remedy which seeks reduction, setoff, subordination or any recharacterization of the
claim or lien of Lender or the Existing Lenders; or (c) a claim that could reasonably be expected
to have a Material Adverse Effect or could reasonably be expected to have a material adverse effect
on the rights and remedies of Lender under any Loan Documents, the Strategic Alliance Agreement,
the rights and remedies of the Existing Lenders under any Existing Agreement or the collectability
of all or any portion of the Obligations or the Existing Indebtedness, or Borrower or any officer
or employee of Borrower commences any such suit, action or contested matter, or joins with or
actively supports any Official Creditors’ Committee or any other party in interest in the Case in
respect of any such suit, action or contested matter; or

               (r) the entry of an order in the Case confirming a plan of reorganization or a plan of
liquidation that does not contain a provision for termination of all Loan commitments under this
Agreement and repayment in full of the Obligations under this Agreement and the Existing
Indebtedness (with respect to the Existing Indebtedness, subject to such terms as may be agreed
upon by Borrower and Lender in the Strategic Alliance Agreement) on or before the effective date of
such plan; or

               (s) the Final Order is not entered prior to the expiration of the Interim Order and, in any
event, within 30 days following the Interim Order Entry Date; or

               (t) other than payments permitted pursuant to this Agreement, the Interim Order or the Final
Order, as applicable, Borrower shall make any payment (whether by way of adequate protection or
otherwise) of principal or interest or otherwise on account of any Indebtedness incurred prior to
the Petition Date other than to Lender; or

               (u) the payment of, or application for authority to pay, any prepetition claim without
Lender’s prior written consent or pursuant to an order of the Bankruptcy Court after notice and a
hearing unless otherwise permitted under this Agreement; or

               (v) the allowance of any claim or claims under Section 506(c) of the Bankruptcy Code against
or with respect to any Collateral other than the Carve-Out; or

               (w) the material breach by Borrower of the Strategic Alliance Agreement; or

               (x) any attempt by Borrower to assign, or the assignment of, Borrower’s rights and obligations
under the Strategic Alliance Agreement to a third party without Lender’s prior written consent; or

-25-

 

               (y) absent the prior written consent of Lender, entry by the Bankruptcy Court of an order
under Section 363 or 365 of the Bankruptcy Code authorizing or approving the sale or assignment of
a material portion of Borrower’s assets, or procedures in respect thereof, or Borrower shall seek,
support, or fail to contest in good faith, the entry of such an order in the Case; or

               (z) the entry of an order in the Case avoiding or requiring repayment of any portion of the
payments made on account of the Obligations owing under this Agreement;

          8.2
Exercise of Rights. Upon the occurrence of an Event of Default, Lender shall have the
right to exercise its rights and remedies under Section 9 of this Agreement or as contained
elsewhere in the Loan Documents upon three (3) Business Days’ written notice to Borrower, the U.S.
Trustee and any statutory committee appointed in the Case, all without requirement for further
order of the Bankruptcy Court or obtaining relief from the automatic stay imposed by Section 362(a)
of the Bankruptcy Code, but subject to any additional requirement for the giving of notice by the
terms of the Interim Order or the Final Order. Further, such automatic stay shall not limit the
right of Lender to take such steps as it determines in its discretion are necessary or desirable to
perfect any of the DIP Liens even absent an Event of Default under the Loan Documents.

SECTION 9

LENDER’S RIGHTS AND REMEDIES

          9.1 Rights and Remedies. In every such Event of Default and at any time thereafter during the
continuance of such Event of Default, and without further order of or application to the Bankruptcy
Court, Lender may, upon three (3) Business Days notice to Borrower, exercise all its rights and
remedies under this Agreement, the Loan Documents and applicable law, including but not limited to,
taking one or more of the following actions, at the same or different times:

               (a) Declare all Obligations (including fees and Lender Expenses), whether evidenced by this Agreement, by any other
Loan Document, or otherwise, immediately due and payable;

               (b) Cease advancing money or extending credit to or for the benefit of Borrower under this
Agreement, under any of the Loan Documents, or under any other agreement between Borrower and
Lender;

               (c) Terminate this Agreement and any of the other Loan Documents as to any future liability or
obligation of Lender, but without affecting Lender’s rights and security interests in the
Collateral and without diminishing the Obligations;

               (d) Settle or adjust disputes and claims directly with account debtors for amounts and upon
terms which Lender considers advisable, and in such cases, Lender will credit Borrower’s loan
account with only the net amounts received by Lender in payment of such disputed Accounts after
deducting all Lender Expenses incurred or expended in connection therewith;

-26-

 

               (e) Make such payments and do such acts as Lender considers necessary or reasonable to protect
the Collateral or Lender’s security interests in the Collateral.
Borrower agrees to assemble the Collateral if Lender so requires (including originals and
copies of all books, records, correspondence, files and other documentation regarding Borrower’s
Intellectual Property), and to make the Collateral available to Lender as Lender may designate.
Borrower authorizes Lender to enter the premises where the Collateral is located, to take and
maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or
compromise any encumbrance, charge or lien that in Lender’s determination appears to be prior or
superior to its security interests and to pay all expenses incurred in connection therewith;

               (f) Without constituting a retention of any Collateral in satisfaction of an obligation
(within the meaning of the UCC), set off and apply to the Obligations any and all (i) balances and
deposits of Borrower held by Lender, or (ii) Indebtedness at any time owing to or for the credit or
the account of Borrower held by Lender;

               (g) Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale or other
disposition, the Collateral;

               (h) Apply to the Bankruptcy Court upon proper notice for one or more of the following forms of
relief: (i) appointment of an examiner for Borrower; (ii) appointment of a Chapter 11 trustee for
Borrower; (iii) conversion of the Case to a case under Chapter 7 of the Bankruptcy Code; or (iv)
dismissal of the Case. Nothing in this paragraph shall limit the right of Lender to apply to the
Bankruptcy Court for such other or further relief as may be justified and appropriate, and nothing
in this paragraph shall limit the other rights and remedies of Lender provided for elsewhere in
this Agreement or in any other Loan Document;

               (i) Sell, license or otherwise dispose of the Collateral (including Borrower’s Intellectual
Property) at either a public or private sale, or both, by way of one or more contracts or
transactions, for cash or on terms, in such manner and at such places as Lender determines is
commercially reasonable;

               (j) Lender may credit bid pursuant to Section 363(k) of the Bankruptcy Code an aggregate
amount up to its Existing Indebtedness and all Obligations owed to it under this Agreement and
purchase at any sale any assets securing such Existing Indebtedness and Obligations, respectively;

               (k) Any deficiency that exists after disposition of the Collateral will be paid immediately by
Borrower. Any excess will be returned to Borrower;

               (l) Make a request and cause Borrower to assign and/or transfer to Lender such FDA clearance
or standing as registrant, petitioner and/or applicant and/or other status as Borrower may obtain
for the OVA-1 test; and

               (m) In addition to the foregoing rights in this Section 9.1, Lender shall have all
other rights and remedies available to it under the UCC or otherwise at law or in equity or
pursuant to any other Loan Documents.

-27-

 

          9.2 Remedies Cumulative. Lender’s rights and remedies under this Agreement, the Loan
Documents, and all other agreements shall be cumulative. Lender shall have all other rights and
remedies not inconsistent herewith as provided under the Bankruptcy Order(s), the Bankruptcy Code,
the UCC, by law, or in equity. No exercise by Lender of one right or remedy shall be deemed an
election, and no waiver by Lender of any Event of Default shall be deemed a continuing waiver. No
delay by Lender shall constitute a waiver, election or acquiescence by it.

SECTION 10

TAXES AND EXPENSES

          If Borrower fails to pay any monies (whether taxes, rents, assessments, insurance premiums, or
otherwise) due to third Persons, or fails to make any deposits or furnish any required proof of
payment or deposit, to the extent required under the terms of this Agreement and permitted by the
Bankruptcy Code, then, to the extent that Lender determines that such failure by Borrower could
have a material adverse effect on Lender’s interests in the Collateral, in its discretion and
without prior notice to Borrower, Lender may do any or all of the following: (a) make payment of
the same or any part thereof; (b) set up such reserves in Borrower’s loan account as Lender deems
necessary to protect Lender from the exposure created by such failure; or (c) obtain and maintain
insurance policies of the type described in Section 6.6, and take any action with respect
to such policies as Lender deems prudent. Any such amounts paid by Lender shall constitute Lender
Expenses. Any such payments made by Lender shall not constitute an agreement by Lender to make
similar payments in the future or a waiver by Lender of any Event of Default under this Agreement.
Lender need not inquire as to, or contest the validity of, any such expense, tax, security
interest, encumbrance, or lien and the receipt of the usual official notice for the payment thereof
shall be conclusive evidence that the same was validly due and owing.

SECTION 11

WAIVERS; INDEMNIFICATION

          11.1 Demand; Protest; etc. Borrower waives demand, protest, notice of protest, notice of
default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at
maturity, release, compromise, settlement, extension, or renewal of accounts, documents,
instruments, chattel paper, and guarantees at any time held by Lender on which Borrower may in any
way be liable.

          11.2 Lender’s Liability for Collateral. Lender shall not in any way or manner be liable or
responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage thereto occurring
or arising in any manner or fashion from any cause; (c) any diminution in the value thereof; or (d)
any act or default of any carrier, warehouseman, bailee, forwarding agency, or other Person. All
risk of loss, damage, or destruction of the Collateral shall be borne by Borrower.

          11.3 Indemnification. Borrower agrees to defend, indemnify, save, and hold Lender and its
agents harmless against: (a) all obligations, demands, claims, and liabilities claimed or asserted
by any other Person arising out of or relating to the transactions

-28-

 

contemplated by this Agreement or any other Loan Document, and (b) all losses (including
attorneys fees and disbursements) in any way suffered, incurred, or paid by Lender as a result of
or in any way arising out of, following, or consequential to the transactions contemplated by this
Agreement or any other Loan Document, except, in any such case, to the extent that the same arises
from the gross negligence or willful misconduct of Lender or its officers, agents, or employees.
This provision shall survive the termination of this Agreement.

SECTION 12

NOTICES

          Unless otherwise provided in this Agreement, all notices or demands by any party relating to
this Agreement or any other Loan Document shall be in writing and shall be personally delivered or
sent by registered or certified mail, postage prepaid, return receipt requested, telefacsimile, or
nationally recognized overnight courier to Borrower or to Lender, as the case may be, at its
address set forth below:

	 	If to Borrower:         	 	Vermillion, Inc.

47350 Fremont Blvd.

Fremont, CA 94538

Attn: Gail Page

Fax: (510) 226-2801
	 
	 	with a copy to: 	 	Robert Claassen, Esq.

Paul, Hastings, Janofsky & Walker, LLP

1117 S. California Avenue

Palo Alto, CA 94304

Fax: (650) 320-1984
	 
	 	If to Lender: 	 	Quest Diagnostics Incorporated

3 Giralda Farms

Madison, NJ 07940

Attn: General Counsel

Fax: (973) 520-2143
	 
	 	with a copy to: 	 	Maria P. Sendra, Esq.

Baker & McKenzie LLP

12544 High Bluff Drive, 3rd Floor

San Diego, CA 92130

Fax: (858) 259-8290
	 
	 	 	 	and

-29-

 

	 	            	 	Christine E. Baur, Esq.

Law Office of Christine E. Baur

4653 Carmel Mountain Road, Suite 308 #332

San Diego, CA 92130

Fax: (858) 876-9480

          The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other. Borrower acknowledges and agrees
that notices sent by Lender in connection with the exercise of enforcement rights against
Collateral under the provisions of the UCC shall be deemed sent when deposited in the mail or
personally delivered, or, where permitted by law, transmitted by telefacsimile or any other method
set forth above.

SECTION 13

CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER

          THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAWS
OF THE STATE OF DELAWARE.

          THE PARTIES AGREE THAT ALL ACTIONS OR PROCEEDINGS ARISING IN CONNECTION WITH THIS AGREEMENT
SHALL BE TRIED AND LITIGATED ONLY IN THE BANKRUPTCY COURT SITTING WITHOUT A JURY. BORROWER AND
LENDER WAIVE, TO THE EXTENT PERMITTED UNDER APPLICABLE LAW, ANY RIGHT EACH MAY HAVE TO ASSERT THE
DOCTRINE OF FORUM NON CONVENIENS OR TO OBJECT TO VENUE TO THE EXTENT ANY PROCEEDING IS BROUGHT IN
ACCORDANCE WITH THIS SECTION 13. SERVICE OF PROCESS IN ANY SUCH ACTION MAY BE MADE BY
DELIVERY THEREOF IN ACCORDANCE WITH SECTION 12.

SECTION 14

GENERAL PROVISIONS

          14.1 Effectiveness. Subject to entry of the Interim Order and the Final Order, as applicable,
this Agreement shall be binding and deemed effective when executed by Borrower and accepted and
executed by Lender.

          14.2 Successors and Assigns. This Agreement shall bind and inure to the benefit of the
respective successors and assigns of each of the parties; provided, however, that
Borrower may not assign this Agreement or any rights or duties hereunder without Lender’s prior
written consent and any prohibited assignment shall be absolutely void. No consent to an
assignment by Lender shall release Borrower from its Obligations. Lender may assign this Agreement
and its rights and duties hereunder with the consent of the Borrower (such consent not to be
unreasonably withheld or delayed). In connection with any such assignment, Lender may disclose all
documents and information which Lender now or hereafter may have relating to Borrower or Borrower’s
business, subject to a confidentiality agreement in form and substance reasonably satisfactory to
Borrower. To the extent that Lender assigns its rights and obligations

-30-

 

hereunder to a third Person, Borrower shall not be relieved of any liability under this
Agreement as a result of such assignment or delegation.

          14.3 Section Headings. Headings and numbers have been set forth herein for convenience only.
Unless the contrary is compelled by the context, everything contained in each section applies
equally to this entire Agreement.

          14.4 Interpretation. Neither this Agreement nor any uncertainty or ambiguity herein shall be
construed or resolved against Lender or Borrower, whether under any rule of construction or
otherwise. On the contrary, this Agreement has been reviewed by all parties and shall be construed
and interpreted according to the ordinary meaning of the words used so as to fairly accomplish the
purposes and intentions of all parties hereto.

          14.5 Good Faith. Each of the parties hereto agrees that it will exercise its rights and
remedies hereunder, and perform each of its obligations hereunder, in a commercially reasonable
manner and in good faith.

          14.6 Severability of Provisions. Each provision of this Agreement shall be severable from
every other provision of this Agreement for the purpose of determining the legal enforceability of
any specific provision.

          14.7 Amendments, etc. No modification, amendment or waiver of any provision of this Agreement
or the other Loan Documents, and no consent to any departure by Borrower, shall in any event be
effective unless the same shall be in writing and signed by Lender, and then such waiver or consent
shall be effective only in the specific instance and for the purpose for which given. No notice to
or demand on Borrower shall entitle Borrower to any other or further notice or demand in the same,
similar or other circumstances. No amendment to this Agreement shall be effective against Borrower
unless signed by Borrower.

          14.8 Confidentiality. Lender agrees to keep any information delivered or made available by
Borrower to it confidential from anyone other than persons employed or retained by Lender who are
or are expected to become engaged in evaluating, approving, structuring or administering the Loans;
provided, that nothing herein shall prevent Lender from disclosing such information (i) to
any of its affiliates, provided such affiliate agrees to keep such information confidential to the
same extent required by Lender hereunder, (ii) upon the order of any court or administrative
agency, (iii) upon the request or demand of any regulatory agency or authority, (iv) which has been
publicly disclosed other than as a result of a disclosure by Lender or its affiliates which is not
permitted by this Agreement, (v) in connection with any litigation to which Lender or its
affiliates be a party to the extent reasonably required, (vi) to the extent reasonably required in
connection with the exercise of any remedy hereunder, and (vii) to Lender’s legal counsel and
independent auditors. Lender shall use reasonable efforts to notify Borrower of any required
disclosure under clauses (ii) and (v) of this Section.

          14.9 Counterparts; Telefacsimile Execution. This Agreement may be executed in any number of
counterparts and by different parties on separate counterparts, each of which, when executed and
delivered, shall be deemed to be an original, and all of which, when taken together, shall
constitute but one and the same Agreement. Delivery of an executed

-31-

 

counterpart of this Agreement by telefacsimile shall be equally as effective as delivery of a
manually executed counterpart of this Agreement. Any party delivering an executed counterpart of
this Agreement by telefacsimile also shall deliver a manually executed counterpart of this
Agreement but the failure to deliver a manually executed counterpart shall not affect the validity,
enforceability and binding effect of this Agreement.

          14.10 Revival and Reinstatement of Obligations. If the incurrence or payment of the
Obligations by Borrower or the transfer of any property by Borrower to Lender should for any reason
subsequently be declared to be void or voidable under any state or federal law relating to
creditors’ rights, including provisions of the Bankruptcy Code relating to fraudulent conveyances,
preferences, and other voidable or recoverable payments of money or transfers of property
(collectively, a “Voidable Transfer”), and if Lender is required to repay or restore, in
whole or in part, any such Voidable Transfer, or elects to do so upon the reasonable advice of its
counsel, then, as to any such Voidable Transfer, or the amount thereof that Lender is required or
elects to repay or restore, and as to all reasonable costs, expenses, and attorneys fees of Lender
related thereto, the liability of Borrower automatically shall be revived, reinstated, and restored
and shall exist as though such Voidable Transfer had never been made.

          14.11 Integration. This Agreement, together with the other Loan Documents, if any, reflects
the entire understanding of the parties with respect to the transactions contemplated hereby and
shall not be contradicted or qualified by any other agreement, oral or written, whether before or
after the date hereof.

[Signature Page Follows]

-32-

 

          IN WITNESS WHEREOF, each of parties hereto has caused this Agreement to be executed as of the
date set forth in the introductory paragraph of this Agreement.

	 	 	 	 	 
	 	LENDER

Quest Diagnostics Incorporated

 	 
	 	By:  	/s/ Dermot Shorten
 	 
	 	 	Name:  	Dermot Shorten 	 
	 	 	Title:  	VP, Office of the Chairman 

	 
	 
	 	BORROWER

Vermillion, Inc.

 	 
	 	By:  	/s/ Gail S. Page
 	 
	 	 	Name:  	Gail S. Page 	 
	 	 	Title:  	Executive Director 	 
	 

-33-exv10w2

Exhibit 10.2

AMENDMENT TO

STRATEGIC ALLIANCE AGREEMENT

     This Amendment (“Amendment”) to the Strategic Alliance Agreement dated on or about July 22,
2005 as amended from time to time (the “Strategic Alliance Agreement”) and, where indicated, to any
one or all of the Strategic Agreements (defined below), is made as of October 7, 2009 (the
“Effective Date of the Amendment”) by and among Quest Diagnostics Incorporated, a Delaware
corporation (“Quest Diagnostics”) and Vermillion, Inc., a Delaware corporation (“Vermillion”).

RECITALS

     A. On March 30, 2009, Vermillion filed a voluntary petition for relief, thereby commencing
case no. 09-11091 (CSS) (the “Case”) pursuant to Chapter 11 of Title 11 of the United States Code,
11 U.S.C. §§ 101 et seq. (as in effect for purposes of the Case, the
“Bankruptcy Code”), in the United States Bankruptcy Court for the District of Delaware and
has continued in possession of its assets and in the management of its business as a
debtor-in-possession pursuant to Sections 1107(a) and 1108 of the Bankruptcy Code.

     B. Vermillion has requested that Quest Diagnostics provide a senior secured super priority
term loan facility of up to $1,500,000 (one million five hundred thousand dollars) (the “Facility”)
on the terms and conditions set forth in the Loan Agreement (defined below) for Vermillion’s
general working capital and corporate purposes.

     C. Quest Diagnostics has agreed to enter into the Loan Agreement provided that Vermillion
assumes the Strategic Agreements (defined below) pursuant to the terms of this Amendment.

     NOW, THEREFORE, in consideration of the premises and the mutual covenants hereinafter
contained, and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto agree as follows:

AGREEMENT

     1. Vermillion, Inc. Throughout the Strategic Alliance Agreement and the Alliance
Agreements the term “Ciphergen” is hereby replaced with the term “Vermillion.”

     2. Defined Term. Schedule A of the Strategic Alliance Agreement is hereby amended to:

          (i) include the following defined term: “Loan Agreement” means that certain
Debtor-In-Possession Credit and Security Agreement by and between Vermillion and Quest Diagnostics
and dated October 7, 2009.”; and

          (ii) delete and replace in its entirety the current definition of “Agreement” with the
following definition: “Agreement” means the Strategic Alliance Agreement as defined in

 

 

and as amended pursuant to that certain Amendment to Strategic Alliance Agreement made as of
October 7, 2009.”

     3. Base Term. Section 2.7 of the Strategic Alliance Agreement is hereby deleted and
replaced in its entirety with the following provision:

	“2.7	 	Base Term. As used in this Agreement, “Base Term” means the
period beginning on the Effective Date and ending on the earliest of:

(a) the date that is three (3) years after the Effective Date of the
Amendment; or

(b) the date Quest Diagnostics has Commercially Launched three (3) Licensed
Laboratory Tests under this Agreement.

Notwithstanding the foregoing, the Parties shall continue activities after
the Base Term with respect to the development of a Licensed Laboratory Test
and Test Kit to the extent that a Plan has been accepted by Quest Diagnostics
pursuant to Section 4.3 during the Base Term but development activities have
not been completed during the Base Term for a Licensed Laboratory Test and/or
a Test Kit with respect to such Plan. This obligation shall expire two (2)
years after the end of the Base Term.”

     4. Development of Test Kits. Article 7 of the Strategic Alliance
Agreement is hereby amended as follows:

          (i) Section 7.1 of the Strategic Alliance Agreement is hereby amended by
deleting the word “Following” at the beginning of the very first sentence following
the heading, “Ciphergen to Develop the Test Kits.” and replacing it in its
entirety with the phrase, “Subject to Section 7.3 hereof, following”

          (ii) Section 7.2 of the Strategic Alliance Agreement is hereby amended by
deleting the word “The” at the beginning of the very first sentence following the
heading “Roles of the Parties.” and replacing it in its entirety with the
phrase, “Subject to Section 7.3 hereof, the”

          (iii) adding the following new Section 7.3 at the very end of Article 7 of the
Strategic Alliance Agreement:

	“7.3	 	Quest Diagnostics’ Step In Rights and Role with respect to Regulatory Authorities and
Commercialization Activities. Notwithstanding anything to the contrary in any of the
Strategic Agreements (defined below) and without limiting any other of the parties’ respective
rights and remedies under the Strategic Agreements, in equity or law, in the event of:

     (a) an “Event of Default” by Vermillion under and as such term is defined in the Loan
Agreement,

-2-

 

     (b) Quest Diagnostics determining, at its reasonable discretion and with at least 24
(twenty four) hours notice to Vermillion and the Creditors’ Committee in Vermillion’s
bankruptcy, that Vermillion is unable to effectively carry out actions necessary or
appropriate in pursuit and/or maintenance of FDA clearance obligations under any of the
Strategic Agreements or under any other agreement or understanding by and between Quest
Diagnostics and Vermillion and/or,

     (c) Quest Diagnostics determining at its reasonable discretion and at least twenty four
(24) hours notice to Vermillion and the Creditor’s Committee in Vermillion’s bankruptcy,
that the commercial viability or salability of any of the products contemplated under the
Strategic Agreements may be impaired in any way, as evidenced by way of examples only, but
not necessarily limited to, the issuance of an FDA inquiry, “un-titled letter” that results
in a warning letter, or warning letter, any failure or uncured deficiencies in response to
any audits, “483” notices, recalls, market withdrawals, injunctions, seizures, safety
alerts, other warnings, and/or any other deficiencies with respect to quality systems,
recurrent back order deficiencies, product recalls, labeling requirements or otherwise,

	 	 	Vermillion shall assign and/or transfer to Quest Diagnostics such FDA clearance or standing
as registrant, petitioner, applicant and/or other similar status as Vermillion may have or
obtain or which may be otherwise available to Vermillion and/or Quest Diagnostics for the
OVA-1 test and/or for any other ongoing or future tests in connection with any prior,
current or future elections under the Strategic Agreements. Effective immediately upon the
occurrence of any one or a combinations of events set forth in clauses (a), (b) or (c) of
this Section 7.3 (referred to herein as a “Step In Event”), Vermillion hereby grants Quest
Diagnostics with step-in rights and hereby permits Quest Diagnostics to perform or have a
third party perform any and all obligations of Vermillion under the Strategic Agreements
relevant to the Step In Event that has occurred, including without limitation any activities
related to manufacturing, obtaining and maintaining FDA clearance/approval for the
applicable Test Kit or in filing or maintaining applicable intellectual property. In
addition, effective immediately upon a Step-In Event, Vermillion shall duly execute and
deliver, or cause to be duly executed and delivered such further instruments and do and
cause to be done such further acts and things, including without limitation, the filing of
such additional assignments, agreements, documents and instruments, that may be necessary or
as Quest Diagnostics may at any time and from time to time reasonably request in order to
effectuate the purpose of this Section 7.3 and any and all allocations of applicable rights,
responsibilities, and restrictions under the Strategic Agreements, including without
limitation Sections 7.1, 7.2, 8.1, and 9.4 of the Strategic Alliance Agreement, shall, at
Quest Diagnostics’ reasonable discretion and upon at least forty eight (48) hours notice to
Vermillion and the Creditor’s Committee in the Vermillion bankruptcy, become subject to this
Section 7.3. In connection with the foregoing, Vermillion hereby irrevocably makes,
constitutes, and appoints Quest Diagnostics (and any agents designated by Quest Diagnostics)
as Vermillion’s true and lawful attorney, with power to: at any time that a Step In Event
has occurred and is continuing, if Vermillion refuses to, or fails timely to execute and
deliver any of the necessary or appropriate documents, cause to be assigned and/or
transferred to Quest Diagnostics Vermillion’s clearance or standing as registrant,

-3-

 

	 	 	petitioner and/or applicant and/or other similar status as Vermillion may obtain from the
FDA for (x) the OVA-1 test and/or (y) any other ongoing or future tests in connection with
any prior, current or future elections under the Strategic Agreements, as may be applicable
with respect to the respective Step-In Event and Quest Diagnostics exercise of its
respective rights hereunder in connection with such test.

Notwithstanding the foregoing, nothing in this Section 7.3 shall be construed as: (a) granting
Quest Diagnostics any ownership rights in Vermillion’s intellectual property not otherwise already
granted under the terms of any or all of the Strategic Agreements; or (b) limiting Vermillion’s
right to receive payments or royalties otherwise due pursuant and subject to the terms and
conditions of the Strategic Agreements to Vermillion by Quest Diagnostics or any third party.

     5. Commercialization of Licensed Laboratory Test Components and Test Kits. Section
8.1 of the Strategic Alliance Agreement is hereby amended by deleting the word “As” at the
beginning of the very first sentence following the heading, “Restrictions.” and replacing
it in its entirety with the phrase, “Subject to Section 7.3 hereof, as”

     6. Supply Agreement. Section 9.4 of the Strategic Alliance Agreement is hereby
amended by deleting the phrase, “Except as set forth in Section 9.7,” at the very beginning of the
last sentence of Section 9.4 and replacing it in its entirety with the phrase, “Except as set forth
in Sections 7.3 and 9.7,”

     7. Breach of Strategic Documents. Section 15.3 of the Strategic
Alliance Agreement is hereby deleted and replaced in its entirety with the
following provision:

	“15.3	 	Breach of Strategic Agreements. If either Party materially
violates, breaches or fails to perform any term or covenant under any of the
Strategic Agreements and fails to cure such material breach pursuant to the
terms of the respective Strategic Agreement, the non-breaching Party may treat
such material violation, breach or failure to perform as a breach of this
Agreement within the meaning of Section 15.2 hereof. The foregoing shall not
expand or limit any remedies the non-breaching Party is entitled to under the
respective Strategic Agreement.”

     8. Entire Agreement. Section 16.9 of the Strategic Alliance Agreement
is hereby deleted and replaced in its entirety with the following provision:

	“16.9	 	Entire Agreement; Amendment. This Agreement and all Schedules attached hereto, as
amended as of the date hereof, including without limitation pursuant to this Amendment,
together with the Stock Purchase Agreement, the Warrant issued pursuant to the Stock Purchase
Agreement, the Observer Rights Agreement, the Credit Agreement, as modified pursuant to newly
added Section 16.19 under the Amendment, the Security Agreement and any Supply Agreement and
technology escrow agreement entered into in accordance with Article 9 hereof, each as may have
been amended from time to time, (collectively, the “Alliance Agreements”), and the
Loan Agreement contain the entire agreement of the

-4-

 

	 	 	Parties relating to the subject matter hereof and supersede any and all prior agreements,
written or oral, between the Parties relating to the subject matter of this Agreement,
including without limitation the Prior NDA and that certain Option Agreement between the
Parties effective as of June 30, 2005. This Agreement may not be amended unless agreed to
in writing by both Parties. The Strategic Alliance Agreement, this Amendment, the Alliance
Agreements and the Loan Agreement are collectively referred to as the “Strategic
Agreements.” Capitalized terms not otherwise defined herein shall have the meaning set
forth in the Strategic Alliance Agreement.”

     9. Express Assumption of the Strategic Agreements. The following
Section 16.19 is hereby added to the Strategic Alliance Agreement:

	“16.19	 	Express Assumption of the Strategic Agreements; Pre Petition Debt under the
Credit Agreement. For purposes of this Section 16.19, Quest Diagnostics hereby
confirms and agrees that as of the date hereof no defaults or material breaches exist
with respect to any of the Assumed Agreements or to the extent of any defaults or
material breaches, all such defaults and material breaches are hereby waived; provided,
however, that nothing herein shall be deemed a waiver of Quest Diagnostics’ right to
assert any default or material breach or cure with respect to the Assumed Agreements
occurring hereafter.

(a) Assumption of Obligations. Vermillion hereby confirms and agrees that
no waiver by Quest Diagnostics of any default of any terms of any of the Strategic
Agreements shall (x) be deemed or construed as a waiver or relinquishment for the
future of any such term, provision, condition or option or the waiver or
relinquishment of any other term, provision, condition or option or (y) prevent
Quest Diagnostics from requesting adequate assurance of future performance in
connection with the Assumed Agreements (as hereinafter defined). Vermillion further
understands and agrees that in the event the Loan Agreement and/or the respective
Facility there under is terminated for any reason, including without limitation, the
payment of all obligations there under, the Strategic Alliance Agreement, this
Amendment, and the other Alliance Agreements, with the exception of the Credit
Agreement and Security Agreement, shall remain fully and unequivocally assumed and
in full force and effect pursuant to Section 365 of Title 11 of the United States
Code (such assumed agreements, the “Assumed Agreements”). Vermillion further
understands and acknowledges that other than the modifications specifically set
forth herein, the Assumed Agreements will reincorporate all of the remaining rights
and obligations there under, and under current, pre-bankruptcy and ongoing tests and
elections exercised there under, which rights and obligations shall remain in full
force and effect. All such rights and obligations there under shall be assumed,
together with the assumption of this Amendment pursuant to Section 365 of Title 11
of the United States Code, including without limitation, to the full extent
originally anticipated under Section 16.18 of the Strategic Alliance Agreement
except as modified pursuant to the terms herein, and shall constitute binding and
enforceable obligations of Vermillion during its bankruptcy case and upon its
emergence, conversion or dismissal from bankruptcy.

-5-

 

(b) Pre Petition Debt Under the Credit Agreement. Vermillion acknowledges
and agrees that upon the filing of the Case by Vermillion all amounts due under the
Credit Agreement became immediately due and payable to Quest Diagnostics.
Vermillion and Quest Diagnostics hereby agree and acknowledge that as of the date
hereof the total principal amount due to Quest Diagnostics based on the Credit
Agreement is $10,000,000 (such principal amount together with any and all accrued
and outstanding interest thereon collectively referred to herein as the “Pre
Petition Debt”). Without limiting any of its rights in law or equity, Quest
Diagnostics hereby agrees to extend the payment term with respect to the Pre
Petition Debt as follows:

(i) Pre Petition Debt to be Forgiven Upon Achievement of Milestones;
Repayment of Principal and Interest. Provided that no material breach
under any of the Strategic Agreements (other than the Loan Agreement) by
Vermillion has occurred and is continuing, or any event of default which
qualifies as an “Event of Default” under either the Credit Agreement or the Loan
Agreement, which breach or event of default has occurred and is continuing, the
Pre Petition Debt shall be forgiven to the extent that Vermillion achieves
certain milestones set forth on Schedule B of the Credit Agreement with respect
to three Plans presented pursuant to the Strategic Alliance Agreement. In the
event Vermillion fails to achieve certain milestones as set forth on Schedule B
of the Credit Agreement, the principal amount outstanding related to each
milestone not achieved shall be due and payable to Quest Diagnostics in one lump
sum on the third anniversary of the Effective Date of the Amendment (the
“Extended Term”), and notwithstanding anything to the contrary in the Credit
Agreement, the term of the Credit Agreement shall be the Extended Term; provided
that, as currently set forth in Section 7 of the Credit Agreement, the
termination of the Credit Agreement shall not affect Vermillion’s obligation of
repayment pursuant to Section 1.5 of the Credit Agreement, as modified herein,
and until all outstanding principal, interest and late fees have been repaid,
Quest Diagnostics’ rights under Section 4 of the Credit Agreement. Vermillion
understands and agrees that Quest Diagnostics is extending the term of the Pre
Petition Debt on the basis that except to the extent the Loan (as defined under
the Credit Agreement) is forgiven pursuant to Schedule B of the Credit
Agreement, Vermillion is to continue to pay (subject to the immediately
succeeding proviso) to Quest Diagnostics, on a monthly basis and at such time as
any principal is prepaid or paid at maturity, all accrued and unpaid interest on
the Loan (as defined under the Credit Agreement), including all interest accrued
during the pendency of the Case, all pursuant to the terms of the Credit
Agreement and Schedule B attached thereto, including without limitation, with
respect to use of proceeds, timing of payments, events of default, interest and
late payment penalties set forth therein; provided, however, that payment of any
such amounts shall not be required to be made during the pendency of the Case.
For purposes of clarification, Vermillion further acknowledges and agrees, in
consideration of Quest Diagnostics’ forgiveness of Pre Petition Debt strictly
pursuant to the terms of this Section

-6-

 

16.19(b)(i), to reaffirm its covenants and obligations to Quest Diagnostics
under the respective Security Agreement and Credit Agreement, with the sole
modification being that modification to Section 1.5.2 of the Credit Agreement
solely as contemplated under this Section 16.19(b)(i), such modification to be
effective upon curing any Events of Default (as defined in the Credit Agreement)
thereunder.”

     10. Governing Law. This Amendment will be governed by, and construed in accordance
with, the laws of the State of Delaware applicable to contracts to be executed and performed in
that state and without regard to the 1980 Convention on the International Sale of Goods. Each of
the Parties hereby expressly submits to the personal jurisdiction of any court of competent
jurisdiction in California, Delaware, New York or New Jersey with respect to any matter arising out
of or in connection with this Amendment.

     11. References. Notwithstanding anything to the contrary herein, any and all
references to the Strategic Alliance Agreement in any of the Strategic Agreements which are not
strictly and solely historical references to the actual Strategic Alliance Agreement entered into
on or about July 22, 2005, shall refer to the Strategic Alliance Agreement as defined in and as
amended pursuant to this Amendment.

     12. Counterparts. This Amendment may be executed in counterparts, each of which shall
be deemed an original and all of which together shall constitute one and the same instrument.

-7-

 

     IN WITNESS WHEREOF, the parties have executive this Amendment to be effective as of the
Effective Date of the Amendment set forth above.

	 	 	 	 	 
	Quest Diagnostics Incorporated,

A Delaware corporation

 	 	 
	By:  	/s/ Dermot Shorten
 	 	 
	 	Name:  	Dermot Shorten 	 	 
	 	Its:   	 VP, Office of the Chairman 	 
	 
	Vermillion, Inc., A Delaware corporation

 	 	 
	By:  	/s/ Gail S. Page
 	 	 
	 	Name:  	Gail S. Page 	 	 
	 	Its: 	 Executive Director	 
	 

-8-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00164-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00164-of-00352.parquet"}]]