Document:

EX-4.2

 Exhibit 4.2 

FORM OF SECOND AMENDED AND RESTATED 

13% SENIOR SECURED CONVERTIBLE NOTE 
  

			
	[$                    ]	  	August 20, 2014

 N-1 
 THIS NOTE HAS NOT BEEN
REGISTERED UNDER THE SECURITIES ACT, OR ANY APPLICABLE STATE SECURITIES LAW AND MAY NOT BE TRANSFERRED UNLESS (I) THERE IS AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR SUCH APPLICABLE STATE SECURITIES LAWS (ii) PURSUANT
TO RULE 144 OF THE SECURITIES ACT OR (III) IN THE OPINION OF COUNSEL REASONABLY ACCEPTABLE TO THE COMPANY, REGISTRATION UNDER THE SECURITIES ACT OR SUCH APPLICABLE STATE SECURITIES LAWS IS NOT REQUIRED IN CONNECTION WITH SUCH TRANSFER. 

THIS SECURITY IS SUBJECT TO FURTHER RESTRICTIONS ON TRANSFER AND OTHER CONDITIONS AS SET FORTH IN THE REGISTRATION RIGHTS AGREEMENT COPIES OF WHICH ARE ON
FILE AT THE OFFICE OF THE COMPANY AND WILL BE FURNISHED WITHOUT CHARGE TO THE HOLDER OF SUCH SECURITY UPON WRITTEN REQUEST. 
 FOR
VALUE RECEIVED, EMISPHERE TECHNOLOGIES, INC., a Delaware corporation (the “Company”), hereby promises to pay to the order of
[                    ], a
[                    ] (the “Holder”), the principal amount of
[                    ($                   
 )], on the terms set forth herein. The obligations under this Second Amended and Restated 13% Senior Secured Convertible Note (this “Note”) are secured by a first priority security interest in substantially all assets of
the Company pursuant to the Security Agreement and the other Security Documents. This Note amends and restates in its entirety that certain Amended and Restated 13% Senior Secured Convertible Note dated as of May 7, 2013 by Company in favor of
Holder (the “Existing Note”). 
 1. Definitions; Interpretation. 

(a) Definitions. The following terms shall have the meanings ascribed to them below: 

“Additional Documentation” has the meaning ascribed to such term in Section 3(b). 

“Additional Shares of Common Stock” has the meaning ascribed to such term in Section 3(d)(iv). 

“Adjusted Consolidated Free Cash Flow” means, for any period, (a) Net Income (Loss), plus (b) without
duplication and to the extent not already increasing Net Income (Loss), the sum of (i) any extraordinary or nonrecurring gain realized in cash during such applicable period, (ii) cash interest income, (iii) cash dividends from the
Company’s Subsidiaries and (iv) the amount related to items that were deducted from or not added to net income in connection with calculating Net Income (Loss) to the extent such items represented cash received by the Company or any
Subsidiary or did not represent cash paid by the Company or any Subsidiary, during such applicable period (for the avoidance of doubt, any cash received through debt or equity financing transactions during a period will not be included in the
calculation of consolidated free cash flow for that period), minus (c) without duplication and to the extent not already reducing Net Income (Loss), the sum of (i) Taxes paid in cash by the Company and its Subsidiaries during such
applicable period, (ii) Consolidated Interest Expense for such applicable period that is paid in cash, (iii) Capital Expenditures during such applicable period that are paid in cash minus any Indebtedness incurred in connection with any
such Capital Expenditures; provided that for any applicable period, the amount of Capital Expenditures deducted pursuant to this subclause (iii) shall not exceed the Capital Expenditures Cap for such Fiscal Year, (iv) the amount related to
items that were added to or not deducted from net income in calculating Net Income (Loss) to the extent such items represented a cash payment by the Company and its Subsidiaries or did not represent cash received by the Company and its Subsidiaries,
in each case during such applicable period, and (v) the amount of any investment in business development, market development, product development or capital expenditures relating to any MHR Approved Products; provided, that Adjusted
Consolidated Free Cash Flow in respect of any Fiscal Year as determined in accordance with this definition shall be reduced (without duplication and to the extent not already reducing Net Income (Loss) in such Fiscal Year) by any cash amounts used
during such Fiscal Year to (i) redeem the Reimbursement Notes pursuant to Section 4 of the Reimbursement Notes, (ii) reduce the amount of principal and interest outstanding on any Loan under the Facility, including any Loan incurred
pursuant to Section 3(c) of the Facility, pursuant to Section 4(b) of the Facility, (iii) redeem the Convertible Notes pursuant to Section 4(b)(ii) hereof, and (iv) redeem the Bridge Notes pursuant to Section 4(a) of
the Bridge Notes. All of the terms contained within the definition of “Adjusted Consolidated Free Cash Flow” (including such terms contained within any defined terms) shall be determined in accordance with GAAP consistent with the
Company’s practice as of the date hereof. 

  

 “Affiliate” means, as to any Person, any other Person (i) that, directly or
indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, such Person; (ii) who is a director or officer (A) of such Person; (B) of any Subsidiary of such Person; or (C) of any
Person described in clause (i) above with respect to such Person; or (iii) which, directly or indirectly through one or more intermediaries, is the beneficial or record owner (as defined in Rule 13d-3 of the Exchange Act, as is in effect
on the date hereof) of 10% or more of any class of the outstanding voting stock, securities or other equity or ownership interests of such Person; provided that notwithstanding anything else herein to the contrary, any Permitted Holder shall
be deemed not to be an Affiliate of the Company or any Subsidiary. For purposes of this definition, the term “control” (and the correlative terms, “controlled by” and “under common control with”) shall mean the
possession, directly or indirectly, of the power to direct or cause the direction of the management or policies, whether through ownership of securities or other interests, by contract or otherwise. 

“Affiliate Transaction” has the meaning ascribed to such term in Section 7(m). 

  
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 “Asset Sale” means (i) the sale, lease, conveyance or other disposition of
any assets or rights (including, without limitation, a sale/leaseback transaction, and the sale or transfer of any Patent Rights or FDA licenses or approvals) other than any sale, lease, conveyance or other disposition involving assets or rights (or
a series of related sales, leases, conveyances or other dispositions) having a fair market value less than $50,000 individually (which fair market value shall in each case be determined as of the date of such disposition), and other than sales,
conveyances or transfers of inventory in the ordinary course of business consistent with past practices with the prior written consent of the Holder (which shall not be unreasonably withheld); and (ii) the issuance or sale by the Company or any
of its Subsidiaries of Equity Interests of any of the Company’s Subsidiaries. Notwithstanding the foregoing, the following items shall not be deemed to be Asset Sales: (i) a transfer of assets by the Company to a Subsidiary or by a
Subsidiary to the Company or to another Subsidiary; (ii) an issuance or sale of Equity Interests by a Subsidiary to the Company or to another Subsidiary; (iii) a sale or other disposition of property or equipment that has become worn out,
obsolete or otherwise unsuitable for its purpose; (iv) a disposition of Cash Equivalents; (v) Restricted Payments made in accordance with Section 7(q); and (vi) the exercise of rights (including foreclosure) in respect of any
Lien permitted by Section 7(i). 
 “Balance Sheet” means the consolidated balance sheet of the Company. 

“Bankruptcy Code” means the Bankruptcy Code of the United States, and all other liquidation, conservatorship, bankruptcy,
assignment for the benefit of creditors, moratorium, rearrangement, receivership, insolvency, reorganization, or similar debtor relief Laws of the United States or other applicable jurisdictions from time to time in effect and affecting the rights
of creditors generally. 
 “Board of Directors” means the board of directors of the Company. 

“Borrowings” shall have the meaning ascribed to such term in the Facility. 

“Bridge Notes” means the Second Amended and Restated Senior Secured Bridge Promissory Notes, dated as of the date hereof,
issued by the Company, together with any notes issued as paid-in-kind interest in respect thereof. “Budget” means the Company’s operating budget, as updated and amended from time to time pursuant to Section 7(b)(iii). A
copy of the Budget covering the period from January 1, 2013 through December 31, 2013 is attached hereto as Exhibit F. 

“Business Day” means any day that is not a Saturday, a Sunday or a day on which banks are required or permitted to be closed
in the State of New York. 
 “Capital Expenditures” means for any Person in respect of any period, the aggregate of all
expenditures incurred by such Person during such period that are or should be included in “additions to property, plant or equipment” or similar items reflected in the Cash Flow Statement, provided, however, that Capital Expenditures for
the Company and its Subsidiaries shall not include: (i) Capital Expenditures with proceeds of insurance settlements, condemnation awards and other settlements in respect of lost, destroyed, damaged or condemned assets, equipment or other
property to the extent such Capital Expenditures are made to replace or repair such lost, destroyed, damaged or condemned assets, equipment or other property or otherwise to acquire, maintain, develop, construct, improve, upgrade or repair assets or
properties useful in the business of the Company and its Subsidiaries within six (6) months of receipt of such proceeds (or, if not made within such period of six (6) months, are committed to be made during such period), (ii) interest
capitalized during such period, and (iii) the purchase of property, plant or equipment made within six (6) months of the sale of any asset to the extent purchased with the proceeds of such sale (or, if not made within such period of six
(6) months, to the extent committed to be made during such period). 
  

  
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 “Capital Expenditures Cap” means, for any Fiscal Year, an amount as set forth in
the Budget for such Fiscal Year. 
 “Capital Lease” means, for any Person, a lease of any interest in any kind of property
(whether real, personal or mixed) or asset by such Person as lessee that is, should be or should have been recorded as a “capital lease” on the balance sheet of such Person in accordance with GAAP. 

“Capitalized Lease Obligation” means, at the time any determination thereof is to be made, the amount of the liability of the
Company under a Capital Lease that would at that time be required to be capitalized on a balance sheet, with the stated maturity being the date of the last payment of rent or any other amount due under such lease prior to the first date upon which
such lease may be prepaid by the lessee without payment of a penalty. 
 “Cash Equivalents” means (i) Dollars,
(ii) securities issued or directly and fully guaranteed or insured by the United States government or any agency or instrumentality thereof (provided that the full faith and credit of the United States is pledged in support thereof)
having maturities of not more than 6 months from the date of acquisition, (iii) certificates of deposit and eurodollar time deposits with maturities of 6 months or less from the date of acquisition, bankers’ acceptances with maturities not
exceeding 6 months and overnight bank deposits, in each case with any domestic commercial bank having capital and surplus in excess of $500,000,000 and a Thompson Bank Watch Rating of “B” or better, (iv) repurchase obligations with a
term of not more than 7 days for underlying securities of the types described in clauses (ii) and (iii) above entered into with any financial institution meeting the qualifications specified in clause (iii) above, (v) commercial
paper having the highest rating obtainable from Moody’s Investors Service, Inc. or Standard & Poor’s Ratings Group and in each case maturing within 6 months after the date of acquisition and (vi) money market funds at least
95% of the assets of which constitute Cash Equivalents of the kinds described in clauses (i)—(v) of this definition. 

“Cash Flow Statement” means the consolidated statements of cash flows of the Company. 

“Cash Flow Sweep Mandatory Redemption” has the meaning ascribed to such term in Section 4(b)(i)(A). 

“Cash Flow Sweep Pro Forma Cash Balance” means the amount of cash and Cash Equivalents set forth on the Balance Sheet as of
any determination date, plus all cash expenditures made and cash expenses incurred during the rolling twelve month period preceding such determination date, in each case other than those cash expenditures and cash expenses relating to the Designated
Products, the Company’s general overhead expenses and any MHR Approved Products; provided that, in the event that any cash amounts are to be used following the determination date (i) to pay Royalties pursuant to Sections 2.3(a) or 2.3(b)
of the Royalty Agreement in respect of the Fiscal Year ending on such determination date, (ii) to repay principal and interest outstanding on any Loans pursuant to Sections 4(a) or 4(c) of the Facility in respect of the Fiscal Year ending on
such determination date, (iii) to redeem the Convertible Notes pursuant to Section 4(b)(iii) hereof in respect of the Fiscal Year ending on such determination date, or (iv) to redeem the Bridge Notes pursuant to Section 4(b) of
the Bridge Notes in respect of the Fiscal Year ending on such determination date, such cash amounts shall be deducted from the calculation of the Cash Flow Sweep Pro Forma Cash Balance as of the end of such Fiscal Year for the purposes of this
definition, but only if such amounts are thereafter actually paid in cash on their respective due dates. 
  

  
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 “Cash Royalty Mandatory Redemption” has the meaning ascribed to such term in
Section 4(b)(iii). 
 “Change of Control” shall be deemed to have occurred when (i) any person (as defined in
Section 13(d)(3) or Section 14(d)(2) of the Exchange Act), other than one or more Permitted Holders, becomes the beneficial owner (as the term “beneficial owner” is defined under Rule 13d-3 under the Exchange Act) of a majority
of the combined voting power of the Common Stock; (ii) the Company merges or consolidates with or into another Person as a result of which the stockholders of the Company immediately prior to the consummation of such transaction do not own at
least 50% of the outstanding voting securities of the remaining, consolidated or successor entity, as the case may be, or the Company sells or disposes of all or substantially all of its assets to any Person; (iii) the liquidation, dissolution,
or the winding up of the affairs of the Company; or (iv) during any 12 month-period following the Closing Date, individuals who at the beginning of such period constituted the Board of Directors (and any new members of the Board of Directors
whose election by the Board of Directors or whose nomination for election by the Company’s stockholders was approved by (A) a vote of a majority of the members of the Board of Directors then still in office who either were directors at the
beginning of such period or whose election or nomination for election was previously so approved or (B) the Permitted Holders), cease for any reason to constitute a majority of the Board of Directors. 

“Cash Royalty Pro Forma Cash Balance” means the amount of cash and Cash Equivalents set forth on the Balance Sheet as of any
determination date, plus all cash expenditures made and cash expenses incurred during the rolling twelve month period preceding such determination date, in each case other than those cash expenditures and cash expenses relating to the Designated
Products, the Company’s general overhead expenses and any MHR Approved Products; provided that, in the event that any cash amounts are to be used following the determination date (i) to pay Royalties pursuant to Sections 2.3(a) or 2.3(b)
of the Royalty Agreement in respect of the Fiscal Year or Fiscal Quarter ending on such determination date, or (ii) to repay principal and interest outstanding on any Loans pursuant to Section 4(c) of the Facility in respect of the Fiscal
Year or Fiscal Quarter ending on such determination date, such cash amounts shall be deducted from the calculation of the Cash Royalty Pro Forma Cash Balance as of the end of such Fiscal Year or Fiscal Quarter for the purposes of this definition,
but only if such amounts are thereafter actually paid in cash on their respective due dates. 

  
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 “Closing Date” means August 20, 2014. 

“Code” or “UCC” means the Uniform Commercial Code in effect in the State of New York; provided, that
in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection or priority of, or remedies with respect to a Holder’s Lien on any Collateral is governed by the Uniform Commercial Code as enacted and in
effect in a jurisdiction other than the State of New York, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes of the provisions thereof relating to such
attachment, perfection, priority or remedies and for purposes of definitions related to such provisions. 
 “Collateral”
has the meaning ascribed to such term in Section 2.1 of the Security Agreement. 
 “Common Stock” means the
Company’s common stock, par value $0.01 per share. 
 “Company Intellectual Property” constitutes all present and
future Intellectual Property owned, controlled, licensed or used by the Company or necessary to the conduct of the business of the Company. 

“Company Ongoing SEC Documents” has the meaning ascribed to such term in Section 7(cc). 

“Company SEC Documents” has the meaning ascribed to such term in Section 6(k). 

“Confidential Information” means all proprietary and confidential information or materials possessed or developed, whether
developed before or after the date hereof; including without limitation, information or materials on substances, formulations, technology, equipment, data, reports, Know-How, sources for supply, patent position and business plans, inventions,
discoveries, improvements and methods, marketing techniques or plans, manufacturing and other plant designs, location of operations, and any other information regarding business operations. 

“Consolidated Interest Expense” means, with respect to the Company for any period, the sum of, without duplication, to the
extent paid in cash: (1) the aggregate of the interest expense of the Company and its Subsidiaries for such period, including, without limitation (a) any amortization of debt discount and amortization or write-off of deferred financing
costs (including the amortization of costs relating to interest rate caps or other similar agreements), (b) all capitalized interest and (c) the interest portion of any deferred payment obligation, and (2) the interest component of
Capitalized Lease Obligations paid, accrued and/or scheduled to be paid or accrued by the Company and its Subsidiaries during such period. 

  
 6 

 “Conversion Amount” means the portion of the principal amount of this Note being
converted plus any accrued and unpaid interest thereon through the Conversion Date each as specified in the Notice of Conversion. 

“Conversion Date” means, for any conversion, the date specified in the Notice of Conversion so long as the copy of the Notice
of Conversion is faxed (or delivered by other means resulting in notice) to the Company at or before 11:59 p.m., New York City time, on the Conversion Date indicated in the Notice of Conversion; provided, however, that if the Notice of
Conversion is not so faxed or otherwise delivered before such time, then the Conversion Date shall be the date the Holder faxes or otherwise delivers the Notice of Conversion to the Company. 

“Conversion Price” means $1.25 per share of Common Stock, subject to adjustments as set forth herein. 

“Conversion Shares” has the meaning ascribed to such term in Section 3(a). 

“Convertible Securities” has the meaning ascribed to such term in Section 3(d)(iv)(A). 

“Copyright Licenses” means all written agreements granting any right under any Copyright, including the grant of rights to
manufacture, distribute, exploit and sell materials derived from any Copyright. 
 “Copyrights” means all copyrights
arising under the laws of the United States, any other country or any political subdivision thereof, whether registered or unregistered and whether published or unpublished, all registrations and recordings thereof, and all applications in
connection therewith, including all registrations, recordings and applications in the United States Copyright Office, and the right to obtain all renewals of any of the foregoing. 

“Daily Market Price” means, as of any date of determination, the closing sale price for the Common Stock, for the Trading Day
of such date of determination (subject to equitable adjustment for any stock splits, stock dividends, reclassifications or similar events during such Trading Day or that are not otherwise reflected in such closing price and further subject to
adjustment as provided herein) on the principal United States securities exchange or trading market where the Common Stock is listed or traded as reported by Bloomberg, or if the foregoing does not apply, the closing sale price for the Common Stock
on the OTC Bulletin Board for such security as reported by Bloomberg, or, if no sale price is reported for such security by Bloomberg, the closing sale price as reported in the “pink sheets” by the Pink Sheets LLC, in each case for such
date or, if such date was not a Trading Day for such security, on the next preceding date which was a Trading Day. If the Daily Market Price cannot be calculated for such security as of either of such dates on any of the foregoing bases, the Daily
Market Price of such security on such date shall be the fair market value as reasonably determined by an investment banking firm selected by the Holder and reasonably acceptable to the Company, with the costs of such appraisal to be borne by the
Company. 
 “Delivery Period” has the meaning ascribed to such term in Section 3(c). 

  
 7 

 “Default” means any event that, with the giving of notice or the lapse of time
or both, would constitute an Event of Default. 
 “Default Rate” has the meaning ascribed to such term in
Section 2(b). 
 “Designated Product(s)” means an oral product for human use that includes SNAC and Vitamin B12 (in
any and all dosages and forms), any Related Products, and/or any line extension of any of the foregoing. 
 “Dietary
Supplement” shall have the meaning as currently set forth in the federal Food, Drug, and Cosmetic Act, at 21 U.S.C. § 321(ff). 

“Disqualified Equity Interests” means any Equity Interests that, by their terms (or by the terms of any security into which
they are convertible, or for which they are exchangeable, at the option of the holder thereof), or upon the happening of any event, mature or are mandatorily redeemable, pursuant to a sinking fund obligation or otherwise, or are redeemable at the
option of the holder thereof, in whole or in part, on or prior to the date that is 91 days after the Maturity Date. 
 “Disregarded
Securities” has the meaning ascribed to such term in Section 3(d)(iv)(E). 
 “Dollars” or
“$” means lawful money of the United States. 
 “DTC” has the meaning ascribed to such term in
Section 3(c). 
 “DTC Transfer” has the meaning ascribed to such term in Section 3(c). 

“Environmental Law” means any present and future federal, state, local or foreign laws, statutes, ordinances, rules,
regulations and the like, as well as common law, relating to protection of human health or the environment, including but not limited to those relating to Hazardous Substances. 

“Equity Interest” means, (i) with respect to any Person that is a corporation, any and all shares, interests,
participations or other equivalents (however designated and whether or not voting) of corporate stock, including each class of common stock and preferred stock of such Person and all options, warrants or other rights to purchase or acquire any of
the foregoing; and (ii) with respect to any Person that is not a corporation, any and all partnership, membership or other equity interests of such Person, and all options, warrants or other rights to purchase or acquire any of the foregoing.

 “ERISA” means the Employee Retirement Income Security Act of 1974. 

“ERISA Affiliate” means, with respect to the Company or any Subsidiary, any trade or business (whether or not incorporated)
that, together with the Company or Subsidiary, is treated as a single employer within the meaning of Sections 414(b), (c), (m) or (o) of the IRC. 

  
 8 

 “ERISA Event” means, with respect to the Company or any Subsidiary or ERISA
Affiliate, (i) the complete or partial withdrawal (as such terms are defined in Sections 4203 and 4205 of ERISA, respectively) of the Company or any Subsidiary or ERISA Affiliate from any Multiemployer Plan; (ii) the institution of
proceedings to terminate a Multiemployer Plan by the PBGC; (iii) the failure by the Company or any Subsidiary or ERISA Affiliate to make when due required contributions to a Multiemployer Plan unless such failure is cured within 30 days;
(iv) any other event or condition that might reasonably be expected to constitute grounds under Section 4042 of ERISA for the termination of, or the appointment of a trustee to administer, any Multiemployer Plan or for the imposition of
liability under Section 4069 or 4212(c) of ERISA; (v) the termination of a Multiemployer Plan under Section 4041A of ERISA or the reorganization or insolvency of a Multiemployer Plan under Section 4241 or 4245 of ERISA;
(vi) the loss of a Qualified Plan’s qualification or tax exempt status; or (vii) any other event or condition that could constitute grounds for the imposition of material liability with respect to any Plan and which, if curable, is
not cured within 30 days. 
 “Event of Default” has the meaning ascribed to such term in Section 8(a). 

“Excepted Transaction” has the meaning ascribed to such term in Section 7(v). 

“Excess Adjusted Consolidated Free Cash Flow” has the meaning ascribed to such term in Section 4(b)(i)(A). 

“Exchange Act” means the Securities Exchange Act of 1934. 

“Excluded Issuances” has the meaning ascribed to such term in Section 3(d)(v). 

“Extraordinary Cash Proceeds” has the meaning ascribed to such term in Section 4(b)(ii). 

“Extraordinary Cash Proceeds Mandatory Redemption” has the meaning ascribed to such term in Section 4(b)(ii). 

“Extraordinary Event” has the meaning ascribed to such term in Section 3(d)(iii). 

“Facility” means the facility pursuant to that certain loan agreement, dated as of the date hereof, by and between the MHR
Funds and the Company. 
 “FDA” means the Food and Drug Administration, as from time to time constituted, created under the
Food and Drug Act of 1906. 
 “Fiscal Quarter” means the respective periods of three (3) consecutive calendar months
ending on March 31, June 30, September 30 and December 31. 
 “Fiscal Year” means each
successive period of twelve (12) months commencing on January 1 and ending on December 31. 
 “GAAP” means
generally accepted accounting principles in the United States of America in effect from time to time as applied by nationally recognized accounting firms. 

  
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 “Guarantee” by any Person means any obligation, contingent or otherwise, of such
Person guaranteeing, or having the economic effect of guaranteeing, any Indebtedness of any other Person (the “Primary Obligor”) in any manner, whether directly or indirectly, and including, without limitation, any obligation of
such Person: (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or to purchase (or to advance or supply funds for the purchase of) any security for the payment of such Indebtedness, (ii) to
purchase property, securities or services for the purpose of assuring the holder of such Indebtedness of the payment of such Indebtedness, or (iii) to maintain working capital, equity capital or other financial statement condition or liquidity
of the Primary Obligor so as to enable the Primary Obligor to pay such Indebtedness (and “Guaranteed,” “Guaranteeing” and “Guarantor” shall have meanings correlative to the foregoing);
provided, however, that the Guarantee by any Person shall not include endorsements by such Person for collection or deposit, in either case, in the ordinary course of business. 

“Guarantors” means any Subsidiary of the Company that executes a guaranty in accordance with Section 7(t). 

“Hazardous Substances” includes, but is not limited to, any and all substances defined, listed or otherwise classified as
pollutants, hazardous wastes, medical wastes, hazardous substances, radiological substances, hazardous materials, extremely hazardous wastes or words of similar meaning or regulatory effect under any present or future Environmental Laws, or that may
have a negative impact on human health or the environment. 
 “Hedge Agreement” means any and all transactions, agreements
or documents now existing or hereafter entered into by the Company which provide for an interest rate, credit, commodity or equity swap, cap, floor, collar, forward foreign exchange transaction, currency swap, cross currency rate swap, currency
option, or any combination of, or option with respect to, these or similar transactions, for the purpose of hedging exposure to fluctuations in interest or exchange rates, loan, credit exchange, security or currency valuations or commodity prices.

 “Income Statement” means the consolidated statements of operations of the Company. 

“Indebtedness” of any Person means, without duplication, (i) all obligations of such Person for borrowed money;
(ii) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments and all reimbursement or other obligations in respect of letters of credit, bankers acceptances, interest rate swaps, hedges, derivatives or
other financial products; (iii) all obligations of such Person as a lessee under Capital Leases; (iv) all obligations or liabilities of others secured by a Lien on any asset of such Person, irrespective of whether such obligation or
liability is assumed; (v) all obligations of such Person to pay the deferred purchase price of assets; (vi) all obligations of such Person owing under Hedge Agreements; and (vii) any obligations of such Person guaranteeing or intended
to guarantee (whether directly or indirectly guaranteed, endorsed, co-made, discounted, or sold with recourse) any obligation of any other Person that constitutes Indebtedness of such other Person under any of clauses (i) through
(vi) above. 

  
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 “Indebtedness Repayment Condition” shall have the meaning as defined in the
Royalty Agreement. 
 “Intellectual Property” means the collective reference to all rights, priorities and privileges
relating to intellectual property, whether arising under United States, multinational or foreign laws or otherwise, including the Know-How, Copyrights, the Copyright Licenses, the Patents, the Patent Licenses, the Trademarks and the Trademark
Licenses, and all rights to sue at law or in equity for any infringement or other impairment thereof, including the right to receive all proceeds and damages therefrom. 

“Interest Rate” has the meaning ascribed to such term in Section 2(b). 

“Investment Agreement” means Investment and Exchange Agreement, dated September 26, 2005 among the Company, MHR Capital
Partners (500) LP, MHR Capital Partners (100) LP, MHR Institutional Partners II LP and MHR Institutional Partners IIA LP. 

“Investment Guidelines” means the Company’s Corporate Investment Policy, a copy of which is attached hereto as
Exhibit D. 
 “Investments” means, (i) any direct or indirect purchase or other acquisition by the Company or
any Subsidiary of any Equity Interest, or other ownership interest in, any other Person, and (ii) any direct or indirect loan, advance or capital contribution by the Company or any Subsidiary to any other Person, including all indebtedness and
accounts receivable from that other Person that are not current assets or did not arise from sales to that other Person in the ordinary course of business. 

“IRC” means the Internal Revenue Code of 1986, and the Treasury Regulations (final, temporary and, as applicable, proposed)
promulgated thereunder. 
 “Know-How” means any and all proprietary unpatented technical information, data, ideas, test
results, inventions, instructions, processes, knowledge, techniques, discoveries, formulae, specifications, designs, regulatory filings, and biological or other materials (including, without limitation, biological, chemical, toxicological, physical
and analytical, safety, manufacturing and quality control data and information). 
 “Knowledge” means, with respect to the
knowledge of the Company, the knowledge of the chief executive officer or the chief financial officer of the Company after due and diligent inquiry. 

“Lien” means any mortgage or deed of trust, pledge, hypothecation, assignment, security deposit arrangement, lien, charge,
claim, security interest, easement or encumbrance, or preference, priority or other security agreement or preferential arrangement of any kind or nature whatsoever (including any lease or title retention agreement, any financing lease having
substantially the same economic effect as any of the foregoing, and the filing of, or agreement to give, any financing statement perfecting a security interest under the Code or comparable law of any jurisdiction). 

  
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 “Line of Business” means (i) the Company’s development, manufacturing,
marketing and sales of Designated Products throughout the world, either alone or with corporate partners, (ii) the Company acquiring through in-licensing or internal development and marketing other medical foods and products incorporating
Eligen®, (iii) the Company’s continued development of improved dosage forms of drugs, either alone or with corporate partners, by applying its proprietary Eligen® technology to those drugs or licensing its Eligen® technology to partners who apply it to their products, and (iv) the continuation
of the Company’s existing agreements with Novartis and Novo Nordisk for products containing the Eligen® technology. 

“Loan” shall have the meaning ascribed to such term under the Facility. 

“Loan Agreement” means the Senior Secured Term Loan Agreement, dated September 26, 2005, between the Company and MHR
Institutional Partners IIA LP. 
 “Loan Documents” means this Note, the Investment Agreement, the Restructuring Agreement,
the Security Documents and any certificates, instruments, agreements or other documents executed in connection herewith or therewith. 

“Mandatory Redemption” has the meaning ascribed to such term in Section 4(b)(iv). 

“Mandatory Redemption Date” means (i) with respect to any Fiscal Year for which there is a Cash Flow Sweep Mandatory
Redemption, the date that is thirty (30) days after the end of such Fiscal Year, (ii) with respect to any Fiscal Year in which there is Unpaid EACFCF outstanding during such Fiscal Year, the date that is thirty (30) days after the end
of such Fiscal Year, (iii) with respect to any Extraordinary Cash Proceeds Mandatory Redemption, the date that is thirty (30) days after the date on which the applicable Extraordinary Cash Proceeds were received by the Company or any of
its Subsidiaries, and (iv) with respect to any Cash Royalty Mandatory Redemption, the date that the corresponding Royalty is due and payable pursuant to the Royalty Agreement; provided that if any Mandatory Redemption Date falls on a day
other than a Business Day, such Mandatory Redemption Date shall instead be the next date that is a Business Day. 
 “Mandatory
Redemption Price” has the meaning ascribed to such term in Section 4(b)(iv). 
 “Material Adverse Effect”
means, individually or together with other adverse effects, any material adverse effect on the liabilities, operations, financial condition, tangible or intangible properties, business or results of operations of the Company and its Subsidiaries
taken as a whole or the ability of the Company to consummate the transactions contemplated hereby or by the other Loan Documents; provided, however, that any such effects resulting from (i) any change affecting the pharmaceutical
industry generally, (ii) any change in general United States economic conditions, (iii) any change in law, rule or regulation or GAAP; except, in the case of each of (i), (ii) and (iii), to the extent that such changes affect the
Company disproportionately to the pharmaceutical industry taken as a whole; (iv) any change, event, occurrence or state of facts directly arising out of or resulting from any action taken, or the failure to take an action, by the Company with
the Holder’s express written consent or in accordance with the express written instructions of the Holder or as otherwise expressly required or explicitly and specifically permitted to be taken by the Company pursuant to the terms of this Note,
the other Loan Documents or the Investment Agreement; or (v) any change in the Company’s stock price or any failure by the Company to meet revenue or earnings projections published by industry analysts (provided that this clause
(v) shall not be construed as providing, or be used or relied upon for any determination, that the change, event, occurrence or state of facts giving rise to such change or failure does not constitute, cause, contribute to or result in a
Material Adverse Effect) shall in each case not be considered when determining if a Material Adverse Effect has occurred. 
  

  
 12 

 “Maturity Date” means March 31, 2022. 

“Medical Food” shall have the meaning as currently set forth in the federal Food, Drug, and Cosmetic Act, at 21 U.S.C. §
360ee(b)(4). 
 “MHR” means MHR Fund Management LLC and any successor thereto. 

“MHR Approved Products” means those products or business opportunities of the Company as the Holders may approve from time to
time in writing in its sole discretion, provided that any such written approval shall specifically reference this Note and indicate that such product or business opportunity shall be included as a MHR Approved Product hereunder. 

“MHR Funds” means MHR Capital Partners Master Account LP, a limited partnership organized in Anguilla, British West Indies,
MHR Capital Partners (100) LP, a Delaware limited partnership, MHR Institutional Partners II LP, a Delaware limited partnership, and MHR Institutional Partners IIA LP, a Delaware limited partnership. 

“Milestones” means the milestones described and set forth in Exhibit E. 

“Multiemployer Plan” means a “multiemployer plan” as defined in Section 4001(a)(3) of ERISA, and to which the
Company or any Subsidiary or ERISA Affiliate is making, is obligated to make or has made or been obligated to make, contributions on behalf of participants who are or were employed by any of them. 

“Net Cash Proceeds” with respect to any issuance or sale of Equity Interests or Indebtedness, means the cash proceeds of such
issuance or sale net of all reasonable and customary attorneys’ fees, accountants’ fees, underwriters’ or placement agents’ fees, discounts or commissions and brokerage, consultant and other fees actually incurred in connection
with such issuance or sale and net of taxes actually paid as a result thereof. 
 “Net Income (Loss)” means the amount
ascribed to the term “Net Income (Loss)” in the Income Statement plus Non-cash Charges less any Non-cash Gains for such period; provided that, unless otherwise approved by the Holder, in the event that the aggregate amount of costs and
expenses in the Income Statement exceed the aggregate amount of costs and expenses specified therefor during the relevant period in the Budget, the aggregate amount of costs and expenses for purposes of determining Net Income (Loss) for purposes of
this definition shall be reduced to the aggregate amount of costs and expenses specified therefor during the relevant period in the Budget. 

  
 13 

 “Non-cash Charges” means the aggregate depreciation, amortization and other
non-cash expenses, charges, commissions, discounts, yields and other fees reducing Net Income (Loss) for such period, including, without limitation, the amortization of intangible assets, deferred financing fees and amortization of unrecognized
prior service costs and actuarial gains and losses related to pensions and other post-employment benefits. 
 “Non-cash
Gains” means the aggregate non-cash gains or income increasing Net Income (Loss) for such period. 
 “Non-Domestic
Intellectual Property” means any and all Intellectual Property other than Intellectual Property arising under the laws of the United States. 

“Notes” means this Note and all other 13% Senior Secured Convertible Notes issued from time to time by the Company in a form
substantially similar to this Note. 
 “Notice of Conversion” has the meaning ascribed to such term in Section 3(b).

 “Obligations” means all principal of and interest (including all interest that accrues after the commencement of any
case or proceeding by or against the Company in bankruptcy, whether or not allowed in such case or proceeding) on this Note, and any penalties, fees, charges, expenses, indemnification payments, reimbursements and any other sum chargeable to the
Company under this Note or any of the other Loan Documents (other than the Investment Agreement). 
 “Officers’
Certificate” means a certificate signed by the chief executive officer and the chief financial officer of the Company and delivered to the Holder. 

“Optional Redemption” has the meaning ascribed to such term in Section 4(a)(i). 

“Optional Redemption Date” has the meaning ascribed to such term in Section 4(a)(ii). 

“Optional Redemption Price” has the meaning ascribed to such term in Section 4(a)(i). 

“Options” has the meaning ascribed to such term in Section 3(d)(iv)(A). 

“OTCBB” has the meaning ascribed to such term in Section 6(d). 

“Ownership Change” has the meaning ascribed to such term in Section 6(y). 

“Patent Licenses” means all agreements, whether written or oral, providing for the grant of any right to manufacture,
use or sell any invention covered in whole or in part by a Patent. 
 “Patent Rights” means any and all Patents and
Patent applications (which for the purposes of this Note shall be deemed to include certificates of invention and applications for certificates of invention) which during the term of this Note are owned by the Company or any of its Subsidiaries or
to which the Company or any of its Subsidiaries through license or otherwise acquires rights, which: (i) have claims covering (x) SNAC, any other similar agent for improved or different bioavailability, the Company’s proprietary
Eligen® technology or any other technology owned or licensed by the Company or any of its Subsidiaries, (y) the Designated Product or (z) the manufacture and/or use of any of the
foregoing; or (ii) are divisions, continuations, continuations-in-part, patents of addition, reissues, renewals, extensions, registrations, confirmations, re-examinations, any provisional applications, supplementary protection certificates or
the like of any such Patents and Patent applications and foreign equivalents thereof. 
  

  
 14 

 “Patents” means (i) all letters patent of the United States, any other
country or any political subdivision thereof, all reissues and extensions thereof and all goodwill associated therewith; (ii) all applications for letters patent of the United States or any other country and all divisions, continuations and
continuations-in-part thereof; and (iii) all rights to obtain any reissues or extensions of the foregoing. 
 “PBGC”
means the Pension Benefit Guaranty Corporation. 
 “Pension Plan” means a Plan described in Section 3(2) of ERISA.

 “Perfected Lien” means a legal, valid and enforceable perfected, first priority lien and security interest under
the internal laws of the relevant state in the United States (without reference to conflicts of law) for the benefit of the Holder, pursuant to the Security Documents. 

“Peril” means, collectively, fire, lightning, flood, windstorm, hail, earthquake, explosion, riot and civil commotion,
vandalism and malicious mischief, damage from aircraft, vehicles and smoke and all other perils covered by the “all-risk” endorsement then in use in the jurisdictions where the properties of the Company and its Subsidiaries are located.

 “Permitted Holders” means each Holder and any Related Party or Affiliate of such Holder. 

“Permitted Liens” means the following: (i) Liens granted to secure payment of the Obligations; (ii) Liens imposed
by law for taxes (other than payroll taxes), assessments or charges of any Governmental Authority for claims not yet due or which are being contested in good faith by appropriate proceedings and with respect to which adequate reserves or other
appropriate provisions are being maintained in accordance with GAAP to the satisfaction of the Holders, in their sole discretion; (iii) (A) statutory Liens of landlords (provided that any such landlord has executed a landlord waiver
and consent in form and substance satisfactory to the Holders, in their sole discretion); and (B) other Liens imposed by law or that arise by operation of law in the ordinary course of business from the date of creation thereof, in each case
only for amounts not yet due or which are being contested in good faith by appropriate proceedings and with respect to which adequate reserves or other appropriate provisions are being maintained in accordance with GAAP to the satisfaction of the
Holders, in their sole discretion; (iv) Liens (A) incurred or deposits made in the ordinary course of business (including, without limitation, surety bonds and appeal bonds) in connection with workers’ compensation, unemployment
insurance and other types of social security benefits or to secure the performance of tenders, bids, leases, contracts (other than for the repayment of Indebtedness), statutory obligations and other similar obligations; or (B) arising as a
result of progress payments under government contracts; (v) purchase money Liens in connection with the purchase by the grantor of such Lien of equipment in the normal course of business; (vi) Liens subordinated in all respects to the Lien
securing payment of the Obligations on terms and conditions and pursuant to an agreement in form and substance satisfactory to the Holder in its sole discretion; (vii) Liens to secure the financing of insurance premiums for insurance policies
obtained pursuant to and in compliance with Section 7(i), provided, that such Liens are limited to the proceeds (including loss payments) of the insurance policies so financed, un-earned premiums on and dividends under such insurance
policies, and the Company’s interest under any state insurance guarantee funds that may arise relating to such insurance policies; and (viii) to the extent constituting a Lien, the transfer of technology licenses in the ordinary course of
business of the Company and otherwise permitted or disclosed hereunder. 

  
 15 

 “Person” means any corporation, limited liability company, natural person, firm,
joint venture, partnership, trust, unincorporated organization or Governmental Authority, or any political subdivision, department or agency of any Governmental Authority. 

“Plan” means, at any time, an “employee benefit plan,” as defined in Section 3(3) of ERISA, that the Company
or any Subsidiary or ERISA Affiliate maintains, contributes to or has an obligation to contribute to on behalf of participants who are or were employed by the Company or any Subsidiary. 

“Precedent Obligations” has the meaning ascribed to such term in Section 19. 

“Proceeding” has the meaning ascribed to such term in Section 10. 

“Proposed Transactions” means the transactions contemplated by the Investment Agreement. 

“Registration Rights Agreement” means the Registration Rights Agreement, dated September 26, 2005, by and among the
Company, MHR Capital Partners (500) LP, MHR Capital Partners (100) LP, MHR Institutional Partners II LP and MHR Institutional Partners IIA LP. 

“Reimbursement Notes” means the Second Amended and Restated Reimbursement Promissory Notes, dated as of the date hereof,
issued by the Company, together with any notes issued as paid-in-kind interest in respect thereof. 
 “Related
Party” means (1) any controlling stockholder, controlling member, general partner, majority owned Subsidiary, or spouse or immediate family member (in the case of an individual) of any Permitted Holder, (2) any estate, trust,
corporation, partnership or other entity, the beneficiaries, stockholders, partners, owners or Persons holding a controlling interest of which consist solely of one or more Permitted Holders and/or such other Persons referred to in the immediately
preceding clause (1), (3) any executor, administrator, trustee, manager, director or other similar fiduciary of any Person referred to in the immediately preceding clause (2) acting solely in such capacity, (4) any investment fund or
other entity controlled by, or under common control with, the Holder or the principals that control the Holder, or (5) upon the liquidation of any entity of the type described in the immediately preceding clause (4), the former partners or
beneficial owners thereof to the extent any Voting Stock may still be held by such entity. 

  
 16 

 “Related Product” shall mean any Dietary Supplement, Medical Food or drug,
whether available over-the-counter or by prescription, in any dosage form, strength or route or mode of administration, containing Vitamin B12, whether in combination with any other vitamin, mineral, nutrient, Dietary Supplement, Medical Food, drug
or active or inactive pharmaceutical ingredient or otherwise, and including SNAC or any other similar agent for improved or different bioavailability using the Company’s proprietary
Eligen® technology or any other technology owned or licensed by the Company or any of its Affiliates. 

“Repayment Date” means the date on which all Obligations are irrevocably repaid in full, in Dollars, to the Holder or
converted into Common Stock pursuant to the terms hereof. 
 “Restricted Payment” means, with respect to the Company or any
Subsidiary, (i) the declaration or payment of any dividend or the incurrence of any liability to make any other payment or distribution of cash or other property or assets in respect of any Equity Interest of such Person, other than a payment
or distribution of Equity Interests in connection with the exercise of any warrant, option or other right to acquire Equity Interests permitted under or issued pursuant to any Transaction Document or the Restructuring Agreement; (ii) any
payment on account of the purchase, redemption, defeasance, sinking fund or other retirement of any Equity Interest of such Person or any other payment or distribution made in respect thereof, either directly or indirectly, other than a payment made
in Equity Interests in connection with the exercise of any warrant, option or other right to acquire Equity Interests permitted under or issued pursuant to any Transaction Document or the Restructuring Agreement; (iii) any payment made to
redeem, purchase, repurchase or retire, or to obtain the surrender of, any outstanding warrants, options or other rights to acquire any Equity Interest of such Person now or hereafter outstanding, other than a payment made in Equity Interests in
connection with the exercise of any warrant, option or other right to acquire Equity Interests permitted under or issued pursuant to any Transaction Document or the Restructuring Agreement; (iv) any payment of a claim for the rescission of the
purchase or sale of, or for material damages arising from the purchase or sale of, any Equity Interests of such Person or of a claim for reimbursement, indemnification or contribution arising out of or related to any such claim for damages or
rescission; (v) any payment, loan, contribution, or other transfer of funds or other property to any stockholder of such Person, except as otherwise permitted hereunder, in the other Loan Documents or the other Transaction Documents, and other
than payment of compensation in the ordinary course of business to stockholders who are employees of such Person; and (vi) any payment of management or Board of Directors fees (or other fees of a similar nature) or out-of-pocket expenses in
connection therewith by such Person to any Stockholder. 
 “Restructuring Agreement” means the Restructuring Agreement,
dated as of April 26, 2013, by and among the Company, MHR Capital Partners Master Account LP, MHR Capital Partners (100) LP, MHR Institutional Partners II LP and MHR Institutional Partners IIA LP. 

“Retiree Welfare Plan” means, at any time, a welfare plan that provides for continuing coverage or benefits for any
participant or any beneficiary of a participant after such participant’s termination of employment (other than (i) coverage mandated by applicable laws, including without limitation, COBRA continuation coverage; (ii) death benefits or
retirement benefits under any “employee pension plan”, as that term is defined in Section 3(2) of ERISA; (iii) deferred compensation benefits accrued as liabilities on the books of the Company or any Subsidiary or ERISA
Affiliate; or (iv) benefits, the full direct cost of which is borne by current or former employees (or beneficiary thereof)). 

  
 17 

 “Royalty” means any and all amounts payable by to the Holders pursuant to the
Royalty Agreement. 
 “Royalty Agreement” means that certain Royalty Agreement, dated as of the date hereof, among the
Company and the MHR Funds. 
 “Schedule(s)” means the disclosure schedules attached hereto as Exhibit G. 

“SEC” means the United States Securities and Exchange Commission. 

“Securities Act” means the Securities Act of 1933. 

“Security Agreement” means the Amended and Restated Pledge and Security Agreement, dated as of the date hereof, by and
between the Company and MHR Institutional Partners IIA LP, a copy of which is attached hereto as Exhibit B. 
 “Security
Documents” means the collective reference to the Security Agreement (including the Security Agreement (Copyrights); Security Agreement (Patents); Security Agreement (Trademarks) and Security Agreement (Domain Name Registrations) attached
thereto), any account control agreements delivered pursuant to the Loan Documents, any Subsidiary Guaranty, any Subsidiary Security Agreement, the UCC financing statements required to be filed and all other security documents hereafter delivered to
the Holders in connection with granting a Lien on any of the assets of the Company or a Subsidiary to secure the Obligations. 

“SNAC” means the Company’s proprietary Eligen® technology
carrier as set forth on Exhibit A to the Royalty Agreement. 
 “Stockholder” means, with respect to any Person, each holder
of any Equity Interests of such Person. 
 “Subsidiary” means (i) as to the Company, any Person in which more than 25%
of all equity, membership, partnership or other ownership interests is owned directly or indirectly by the Company or one or more of its Subsidiaries; and (ii) as to any other Person, any Person in which more than 25% of all equity, membership,
partnership or other ownership interests is owned directly or indirectly by such Person or by one or more of such Person’s Subsidiaries. Unless otherwise specified in this Note or any Loan Document, references to a Subsidiary refer to a
Subsidiary of the Company. 
 “Subsidiary Guaranty” means a guaranty agreement executed by a Subsidiary pursuant to
Section 7(t), in form and substance satisfactory to the Holder, the Company and such Subsidiary, guaranteeing payment of the Obligations and providing, without limitation, that such Subsidiary shall be bound by the covenants set forth in this
Note, and shall make such representations and warranties as the Holder may require. 

  
 18 

 “Subsidiary Security Agreement” means a pledge and security agreement executed
by a Subsidiary pursuant to Section 7(t), substantially in the form of the Security Agreement, and otherwise in form and substance satisfactory to the Holder, the Company and such Subsidiary, securing payment of the Obligations. 

“Taxes” means any present or future tax, levy, impost, duty, charge, assessment or fee of any nature that is imposed
by any Governmental Authority. “Trademark Licenses” means, collectively, each agreement, whether written or oral, providing for the grant of any right to use any Trademark. 

“Trademarks” means (i) all trademarks, trade names, corporate names, company names, business names, fictitious business
names, trade styles, service marks, logos and other source or business identifiers, and all goodwill associated therewith, now existing or hereafter adopted or acquired, all registrations and recordings thereof, and all applications in connection
therewith, whether in the United States Patent and Trademark Office or in any similar office or agency of the United States, any State thereof or any other country or any political subdivision thereof, or otherwise, and all common-law rights related
thereto; and (ii) the right to obtain all renewals thereof. 
 “Trading Day” shall mean any day on which the principal
United States securities exchange or trading market where the Common Stock is then listed or traded, is open for trading. 

“Transaction Documents” shall have the meaning ascribed thereto in the Investment Agreement. 

“Trigger Issuance” has the meaning ascribed to such term in Section 3(d)(iv). 

“United States” means the United States of America. 

“Unpaid EACFCF” has the meaning ascribed to such term in Section 4(b)(i)(B). 

“Unpaid EACFCF Mandatory Redemption” has the meaning ascribed to such term in Section 4(b)(i)(B). 

“Voting Stock” of a Person means all classes of Equity Interests or other interests of such Person then outstanding and
normally entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers or trustees thereof. 

(b) Interpretation. The headings of the articles and sections of this Note are included for convenience of reference. They shall not
affect the construction of any provision of this Note. References herein to articles, sections, subsections or exhibits without further identification of the document to which reference is made are references to provisions or parts of this Note. The
words “herein,” “hereof” and “hereunder” are used in this Note to refer to this Note as a whole including all Exhibits and Schedules, as the same may from time to time be amended, restated, modified, or supplemented and
not to any particular section, subsection, or clause contained in this Note or any such Exhibit or Schedule. The meaning given to terms defined herein shall be equally applicable to both the singular and plural forms of such terms. Whenever the
context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms. The words “include,” “includes,” and “including” shall be deemed to be followed by the phrase “without
limitation.” The word “will” shall be construed to have the same meaning and effect as the word “shall”. Unless the context requires otherwise (a) any definition of or reference to any agreement, instrument or other
document herein shall be construed as referring to such agreement, instrument or document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth
herein); (b) any reference to statute shall be construed to refer to such statute as amended from time to time, and any rules and regulations promulgated thereunder; and (c) any reference herein to any Person shall be construed to include
such Person’s successors and permitted assigns. 

  
 19 

 2. Payments of Interest and Principal. Subject to the provisions of this Note, payments of
principal plus interest on the unpaid principal balance of this Note outstanding from time to time, and any applicable additional payments shall be payable in accordance with the following: 

(a) Maturity. On the Maturity Date, the Company shall repay the outstanding principal of this Note, all interest accrued and unpaid on
this Note, all fees and all other obligations due or accrued to the Holder and unpaid on the Maturity Date unless this Note is earlier converted or redeemed in full pursuant to Sections 3 or 4 hereof. If the Maturity Date is a day other than a
Business Day, the maturity thereof shall be extended to the next succeeding Business Day and, with respect to payments of principal, interest thereon shall be payable at the applicable rate during such extension. Contemporaneously with the repayment
of this Note, the Holder shall surrender this Note, duly endorsed, at the office of the Company. 
 (b) Interest. Interest shall
accrue on the outstanding principal of this Note during the period commencing on the date hereof and terminating on the Maturity Date at an annual interest rate (the “Interest Rate”) equal to 13.00% per annum, compounded
monthly, and will be payable in arrears semi-annually on each June 30th and December 31st in kind through issuance to the Holder of
additional Notes (in a form substantially similar to the form of this Note with appropriate notations for the date of issuance and initial principal amount), up to and including the Maturity Date. So long as an Event of Default has occurred and is
continuing, at the election of the Holder, interest shall accrue on all outstanding Obligations at a rate equal to 2% per annum above the Interest Rate (“Default Rate”). Interest at the Default Rate shall accrue from the
initial date of such Event of Default until that Event of Default is cured or waived in writing and shall be payable upon demand and, if not paid when due, shall itself bear interest as provided in this Section. 

(c) Payments. Except as provided in Section 2(b), all payments of principal, interest, fees and other amounts due hereunder shall
be made by the Company in Dollars by wire transfer or by any other method approved in advance by the Holder to the account of the Holder at the address of the Holder set forth in Section 11 hereof or at such other place designated by the Holder
in writing to the Company. 

  
 20 

 (d) Acceleration of the Maturity Date. Notwithstanding anything to the contrary contained
herein, this Note shall become due and payable together with all accrued interest due on the outstanding principal amount hereunder upon the occurrence of an Event of Default in accordance with Section 8(b) hereof. 

3. Conversion. 
 (a)
Conversion at the Option of the Holder. The Holder may, at any time and from time to time on or after the date hereof, convert all or any part of the outstanding principal amount of this Note, plus all accrued interest thereon through the
Conversion Date, into a number of fully paid and nonassessable shares of Common Stock (“Conversion Shares”) upon surrender of this Note. The number of shares of Common Stock issuable upon surrender of this Note shall be determined
in accordance with the following formula: 
 Conversion Amount 

Conversion Price 

(b) Mechanics of Conversion. In order to effect a conversion pursuant to this Section 3, the Holder shall: (a) fax (or
otherwise deliver) a copy of the fully executed Notice of Conversion, attached hereto as Exhibit A (the “Notice of Conversion”), to the Company and (b) surrender or cause to be surrendered this Note, duly endorsed, along
with a copy of the Notice of Conversion as soon as practicable thereafter to the Company. Upon receipt by the Company of a facsimile copy of a Notice of Conversion from a Holder, the Company shall within two (2) Business Days send, via
facsimile, a confirmation to such Holder stating that the Notice of Conversion has been received, advising the Holder of any additional documentation reasonably required by the transfer agent for the Common Stock to issue the Conversion Shares in
the manner provided in the Notice of Conversion (the “Additional Documentation”) and the name and telephone number of a contact person at the Company regarding the conversion. The Company shall not be obligated to issue Conversion
Shares upon a conversion unless either this Note is delivered to the Company as provided above, or the Holder notifies the Company that such certificates have been lost, stolen or destroyed and delivers the documentation to the Company required by
Section 14. 
 (c) Delivery of Conversion Shares Upon Conversion. Upon the surrender of this Note accompanied by a Notice of
Conversion and any Additional Documentation, the Company shall, no later than the later of (a) the second Business Day following the Conversion Date and (b) the third Business Day following the date of such surrender (or, in the case of
lost, stolen or destroyed certificates, after provision of indemnity pursuant to Section 14) (the “Delivery Period”), issue and deliver to the Holder or its nominee (x) that number of Conversion Shares issuable upon
conversion of the portion of this Note being converted and (y) a new Note in the form hereof representing the balance of the principal amount hereof not being converted, if any. If the Company’s transfer agent is participating in the
Depositary Trust Company (“DTC”) Fast Automated Securities Transfer program, and so long as the certificates therefor do not bear a legend and the Holder thereof is not then required to return such certificate for the placement of a
legend thereon, the Company shall cause its transfer agent to electronically transmit the Conversion Shares to the Holder by crediting the account of the Holder or its nominee with DTC, as specified in the Notice of Conversion, through its DTC
Deposit Withdrawal Agent Commission System (“DTC Transfer”). If the aforementioned conditions to a DTC Transfer are not satisfied, the Company shall deliver to the Holder physical certificates representing the Conversion Shares.
Further, the Holder may instruct the Company to deliver to the Holder physical certificates representing the Conversion Shares in lieu of delivering such shares by way of DTC Transfer. 

  
 21 

 (d) Adjustment to Conversion Price. The Conversion Price in effect at any time shall be
subject to adjustment from time to time upon the happening of certain events, as follows: 
 (i) Common Stock Dividends; Common Stock
Splits; Reverse Common Stock Splits. If the Company, at any time while this Note is outstanding, (A) shall pay a stock dividend on its Common Stock, (B) subdivide outstanding shares of Common Stock into a larger number of shares, or
(C) combine outstanding shares of Common Stock into a smaller number of shares, the Conversion Price shall be multiplied by a fraction the numerator of which shall be the number of shares of Common Stock (excluding treasury shares, if any)
outstanding before such event and the denominator of which shall be the number of shares of Common Stock outstanding after such event. Any adjustment made pursuant to this Section 3(d)(i) shall become effective immediately after the record date
for the determination of stockholders entitled to receive such dividend or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification. 

(ii) Subscription Rights. If the Company, at any time while this Note is outstanding, shall fix a record date for the distribution to
all of the holders of Common Stock evidence of its indebtedness or assets or rights, options, warrants or other securities entitling them to subscribe for, purchase, convert to, exchange for or to otherwise acquire any security (excluding those
referred to in Section 3(d)(i) above), then in each such case the Conversion Price at which this Note shall thereafter be exercisable shall be determined by multiplying the Conversion Price in effect immediately prior to the record date fixed
for determination of stockholders entitled to receive such distribution by a fraction, the denominator of which shall be the average Daily Market Price of the Common Stock for the ten (10) Trading Days prior to the record date mentioned above,
and the numerator of which shall be such average Daily Market Price of the Common Stock for the ten (10) Trading Days prior to such record date less the then fair market value at such record date of the portion of such evidence of indebtedness
or assets or rights, options, warrants or other securities so distributed applicable to one outstanding share of Common Stock as determined by the Board of Directors in good faith; provided, however, that in the event of a distribution
exceeding twenty percent (20%) of the net assets of the Company, such fair market value shall be determined by an appraiser selected by the Holder and reasonably acceptable to the Company. The Company shall pay for all such appraisals. Such
adjustment shall be made whenever any such distribution is made and shall become effective immediately after the record date mentioned above. 

(iii) Other Events. In case of (A) any reclassification of the Common Stock into other securities of the Company, (B) any
compulsory share exchange pursuant to which the Common Stock is converted into other securities, cash or property or (C) any merger or consolidation with or into any persons, or any sale or other disposition of all or substantially all of the
assets of the Company to any person (each of (A), (B) or (C), an “Extraordinary Event”), the Holder shall have the right thereafter to convert this Note into shares of stock and other securities, cash and property receivable
upon or deemed to be held by holders of Common Stock following such Extraordinary Event, that the Holder would have been entitled to receive had it converted this Note immediately prior to such Extraordinary Event (without taking into account any
limitations or restrictions on the convertibility of this Note). In the case of an Extraordinary Event, the terms of any such Extraordinary Event shall include such terms so as to continue to give to the Holder the right to receive the securities,
cash or property set forth in this Section 3(d)(iii) upon any conversion following such Extraordinary Event. This provision shall similarly apply to successive Extraordinary Events. For the avoidance of doubt, nothing contained in this clause
(iii) shall be construed to impair the Company’s or the Holder’s rights under Section 5. 

  
 22 

 (iv) Issuance of Additional Shares of Common Stock. Except as provided in subsection
(v) hereof, if and whenever the Company shall issue or sell, or is, in accordance with any of subsections (iv)(A) through (iv)(H) hereof, deemed to have issued or sold, any Additional Shares of Common Stock (defined below) for a consideration
per share less than the Conversion Price in effect immediately prior to the time of such issue or sale, then and in each such case (a “Trigger Issuance”) the then-existing Conversion Price shall be reduced, as of the close of
business on the effective date of the Trigger Issuance, to the lowest price per share at which any share of Common Stock was issued or sold or deemed to be issued or sold in the Trigger Issuance. For purposes of this subsection (iv),
“Additional Shares of Common Stock” means all shares of Common Stock issued by the Company or deemed to be issued pursuant to this subsection (iv), other than Excluded Issuances (as defined in subsection (v) hereof). 

For purposes of this subsection (iv), the following subsections (iv)(A) to (iv)(H) shall also be applicable (subject, in each such case, to
the provisions of subsection (v) hereof) and to each other subsection contained in this subsection (iv): 
 (A) Issuance of Rights
or Options. In case at any time the Company shall in any manner grant (directly and not by assumption in a merger or otherwise) any warrants or other rights to subscribe for or to purchase, or any options for the purchase of, Common Stock or any
stock or security convertible into or exchangeable for Common Stock (such warrants, rights or options being called “Options” and such convertible or exchangeable stock or securities being called “Convertible
Securities”) whether or not such Options or the right to convert or exchange any such Convertible Securities are immediately exercisable, and the price per share for which Common Stock is issuable upon the exercise of such Options or upon
the conversion or exchange of such Convertible Securities (determined by dividing (i) the sum (which sum shall constitute the applicable consideration) of (x) the total amount, if any, received or receivable by the Company as consideration
for the granting of such Options, plus (y) the aggregate amount of additional consideration payable to the Company upon the exercise of all such Options, plus (z), in the case of such Options which relate to Convertible Securities, the
aggregate amount of additional consideration, if any, payable upon the issue or sale of such Convertible Securities and upon the conversion or exchange thereof, by (ii) the total maximum number of shares of Common Stock issuable upon the
exercise of such Options or upon the conversion or exchange of all such Convertible Securities issuable upon the exercise of such Options) shall be less than the Conversion Price in effect immediately prior to the time of the granting of such
Options, then the total number of shares of Common Stock issuable upon the exercise of such Options or upon conversion or exchange of the total amount of such Convertible Securities issuable upon the exercise of such Options shall be deemed to have
been issued for such price per share as of the date of granting of such Options and thereafter shall be deemed to be outstanding for purposes of adjusting the Conversion Price. Except as otherwise provided in subsection (iv)(D), no adjustment of the
Conversion Price shall be made upon the actual issue of such Common Stock or of such Convertible Securities upon exercise of such Options or upon the actual issue of such Common Stock upon conversion or exchange of such Convertible Securities. 

  
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 (B) Issuance of Convertible Securities. In case the Company shall in any manner issue
(directly and not by assumption in a merger or otherwise) or sell any Convertible Securities, whether or not the rights to exchange or convert any such Convertible Securities are immediately exercisable, and the price per share for which Common
Stock is issuable upon such conversion or exchange (determined by dividing (i) the sum (which sum shall constitute the applicable consideration) of (x) the total amount received or receivable by the Company as consideration for the issue
or sale of such Convertible Securities, plus (y) the aggregate amount of additional consideration, if any, payable to the Company upon the conversion or exchange thereof, by (ii) the total number of shares of Common Stock issuable upon the
conversion or exchange of all such Convertible Securities) shall be less than the Conversion Price in effect immediately prior to the time of such issue or sale, then the total maximum number of shares of Common Stock issuable upon conversion or
exchange of all such Convertible Securities shall be deemed to have been issued for such price per share as of the date of the issue or sale of such Convertible Securities and thereafter shall be deemed to be outstanding for purposes of adjusting
the Conversion Price, provided that (a) except as otherwise provided in subsection (iv)(D), no adjustment of the Conversion Price shall be made upon the actual issuance of such Common Stock upon conversion or exchange of such Convertible
Securities and (b) no further adjustment of the Conversion Price shall be made by reason of the issue or sale of Convertible Securities upon exercise of any Options to purchase any such Convertible Securities for which adjustments of the
Conversion Price have been made pursuant to the other provisions of subsection (iv). 
 (C) Change in Warrant Price or Amount.
Notwithstanding the provisions of subsection (iii), if the exercise price provided for in any warrants of the Company on the date hereof is below the Conversion Price and (i) such exercise price is reduced, the then-existing Conversion Price
shall be reduced, as of the close of business on the effective date of such reduction in exercise price by an amount equal to the product of (x) the original exercise price minus (y) the reduced exercise price and (2) a fraction, the
numerator of which is the number of shares of Common Stock that may be acquired upon exercise, if any, of the warrants whose exercise price is reduced and the denominator of which is the aggregate number of shares of Common Stock that may be
acquired upon exercise of all of the outstanding warrants or (ii) the Company amends the terms of such warrants to increase the number of shares of Common Stock that may be acquired upon exercise of the warrants, the then-existing Conversion
Price shall be reduced, as of the close of business on the effective date of amendment by an amount equal to the product of (1) (x) the original exercise price minus (y) the product of the original exercise price and a fraction, the
numerator of which is the old number of shares for which the warrants were exercisable immediately prior to such amendment and the denominator of which is the new number of shares for which the warrants are exercisable immediately following such
amendment and (2) a fraction, the numerator of which is the number of shares of Common Stock that may be acquired upon exercise, if any, of the warrants whose exercise price is reduced and the denominator of which is the aggregate number of
shares of Common Stock that may be acquired upon exercise of all of the outstanding warrants. 

  
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 (D) Change in Option Price or Conversion Rate. Upon the happening of any of the following
events, namely, if the purchase price provided for in any Option referred to in subsection (iv)(A) hereof, the additional consideration, if any, payable upon the conversion or exchange of any Convertible Securities referred to in subsections (iv)(A)
or (iv)(B), or the rate at which Convertible Securities referred to in subsections (iv)(A) or (iv)(B) are convertible into or exchangeable for Common Stock shall change at any time (including, but not limited to, changes under or by reason of
provisions designed to protect against dilution), the Conversion Price in effect at the time of such event shall forthwith be readjusted to the Conversion Price which would have been in effect at such time had such Options or Convertible Securities
still outstanding provided for such changed purchase price, additional consideration or conversion rate, as the case may be, at the time initially granted, issued or sold. 

(E) Calculation of Consideration Received. If any Common Stock, Options or Convertible Securities are issued, granted or sold for cash,
the consideration received therefor will be the amount received by the Company therefor, after deduction of all underwriting discounts or allowances in connection with such issuance, grant or sale. In case any Common Stock, Options or Convertible
Securities are issued or sold for a consideration part or all of which shall be other than cash, including in the case of a strategic or similar arrangement in which the other entity will provide services to the Company, purchase services from the
Company or otherwise provide intangible consideration to the Company, the amount of the consideration other than cash received by the Company (including the net present value of the consideration expected by the Company for the provided or purchased
services) will be the fair market value of such consideration, except where such consideration consists of securities, in which case the amount of consideration received by the Company will be the average Daily Market Price for the ten
(10) Trading Days with respect to such securities thereof prior to the date of receipt. In case any Common Stock, Options or Convertible Securities are issued in connection with any merger or consolidation in which the Company is the surviving
Company, the amount of consideration therefor will be deemed to be the fair market value of such portion of the net assets and business of the non-surviving Company as is attributable to such Common Stock, Options or Convertible Securities, as the
case may be. Notwithstanding anything to the contrary contained herein, if Common Stock, Options or Convertible Securities are issued, granted or sold in conjunction with each other as part of a single transaction or in a series of related
transactions, and one or more of such securities are issued, granted or sold for a price below fair market value (when the aggregate value of such securities is compared with the aggregate amount of consideration received by the Company therefor),
the Holder may elect to determine the amount of consideration deemed to be received by the Company therefor by deducting the difference between the fair value of and the amount paid for any type of securities issued, granted or sold in such
transaction or series of transactions (the “Disregarded Securities”). If the Holder makes an election pursuant to the immediately preceding sentence, no adjustment to the Conversion Price shall be made pursuant to this subsection
(iv)(E) for the issuance of the Disregarded Securities or upon any conversion or exercise thereof. For example, if the Company were to issue convertible notes having a face value of $1,000,000 and warrants to purchase shares of Common Stock at an
exercise price equal to the market price of the Common Stock on the date of issuance of such warrants in exchange for $1,000,000 of consideration, the fair value of the warrants would be subtracted from the $1,000,000 of consideration received by
the Company for the purposes of determining the price per share of Common Stock issuable upon conversion of the convertible notes and for purposes of determining any adjustment to the Conversion Price hereunder as a result of the issuance of the
Convertible Securities. The Holder shall calculate, using standard commercial valuation methods appropriate for valuing such assets, the fair market value of any consideration other than cash or securities; provided, however, that if
the Company does not agree to such fair market value calculation within three (3) Business Days after receipt of such calculation along with reasonably detailed supporting documentation from the Holder, then such fair market value will be
determined in good faith by an investment banker or other appropriate expert of national reputation selected by the Holder (which investment banker or other expert shall not have been engaged or otherwise employed by the Holder within one
(1) year of the date of such engagement hereunder) and reasonably acceptable to the Company, with the costs of such appraisal to be borne by the Company. 

  
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 (F) Other Action Affecting Conversion Price. If the Company takes any action affecting the
Common Stock after the date hereof that would be covered by this Section 3, but for the manner in which such action is taken or structured, which would in any way diminish the value of this Note then the Conversion Price shall be adjusted in
such manner as the Board of Directors of the Company shall in good faith determine to be equitable under the circumstances. 
 (G) Record
Date. In case the Company shall take a record of the holders of its Common Stock for the purpose of entitling them (i) to receive a dividend or other distribution payable in Common Stock, Options or Convertible Securities or (ii) to
subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date shall be deemed to be the date of the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration of such
dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be, provided, however, that any such adjustment in the Conversion Price shall be reversed or shall
not become effective, as applicable, if the Company abandons the action to which the record date pertains. 

  
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 (H) Treasury Shares. The number of shares of Common Stock outstanding at any given time
shall not include shares owned or held by or for the account of the Company or any of its wholly owned Subsidiaries, and the disposition of any such shares (other than the cancellation or retirement thereof) shall be considered an issue or sale of
Common Stock for the purpose of this subsection (iv). 
 (v) Excluded Issuances. Notwithstanding anything to the contrary contained
herein, the Company shall not be required to make any adjustment of the Conversion Price in the case of the issuance of (A) Common Stock, Options and Convertible Securities for a total consideration of less than $10,000,000 during any 24-month
period; (B) Common Stock, Options or Convertible Securities issued to employees or consultants of the Company in connection with their employment or engagement by the Company pursuant to an equity compensation plan in effect as of
April 26, 2013, or as approved by the Board of Directors, which are granted in the ordinary course of business and consistent with past practice; (C) Common Stock or Convertible Securities to employees or consultants of the Company in
connection with their employment or engagement by the Company pursuant to an equity purchase plan in effect as of April 26, 2013, or as approved by the Board of Directors, which are granted in the ordinary course of business and consistent with
past practice; (D) Common Stock upon the conversion or exercise of any warrants outstanding on the date hereof as disclosed in Schedule 3(d)(v), except as set forth in subsection (iv)(C) above; or (E) Common Stock, Options or
Convertible Securities that are issued at or above the market price at the time of issuance; and (F) Common Stock, Options or Convertible Securities approved by the Holder (collectively, “Excluded Issuances”). 

(vi) Weighted Average Adjustment for Issuances. In the event that at any time or from time to time the Company shall issue or sell
Common Stock, Options or Convertible Securities subject to Section 3(d)(iv) for no consideration or for a per share consideration that is greater than the applicable Conversion Price at the time of such issuance or sale but less at the time of
such issuance or sale than the Daily Market Price, then the Conversion Price in effect immediately prior to each such issuance or sale will immediately be reduced to the price determined by multiplying the Conversion Price, in effect immediately
prior to such issuance or sale, by a fraction, (A) the numerator of which shall be (x) the number of shares of Common Stock outstanding immediately prior to such issuance or sale plus (y) the number of shares of Common Stock which the
aggregate consideration received by the Company for the total number of such additional shares of Common Stock so issued or sold would purchase at the Daily Market Price on the last Trading Day immediately preceding such issuance or sale and
(B) the denominator of which shall be the number of shares of Common Stock outstanding immediately after such issue or sale. 

  
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 (e) Fractional Shares. Upon a conversion hereunder, the Company shall not be required to
issue stock certificates representing fractions of shares of the Common Stock, but may if otherwise permitted, make a cash payment in respect of any final fraction of a share based on the closing bid price at such time. If the Company elects not, or
is unable, to make such a cash payment, the Holder shall be entitled to receive, in lieu of the final fraction of a share, one whole share of Common Stock. 

(f) Notice of Adjustments. Upon the occurrence of each adjustment or readjustment of the Conversion Price pursuant to this
Section 3, the Company, at its own expense, shall promptly compute such adjustment or readjustment and prepare and furnish to each Holder a certificate setting forth such adjustment or readjustment and showing in detail the facts upon which
such adjustment or readjustment is based. The Company shall, upon the written request at any time of the Holder, furnish to such Holder a like certificate setting forth (i) such adjustment or readjustment, (ii) the Conversion Price at the
time in effect and (iii) the number of shares of Common Stock and the amount, if any, of other securities or property which at the time would be received upon conversion of this Note. 

4. Redemption. 
 (a)
Optional Redemption. 
 (i) The Company may redeem this Note, in whole or in part, at any time, at a redemption price (the
“Optional Redemption Price”) equal to the principal amount of this Note, plus accrued and unpaid interest thereon through the date of such redemption, if at the time of any such redemption all of the Common Stock into which this
Note (or a portion thereof subject to such redemption) is convertible is freely transferable by the Holder without any restriction pursuant to registration or exemption under all applicable United States federal and state securities laws (such
redemption, an “Optional Redemption”); provided, that the minimum amount of Notes to be redeemed under any single Optional Redemption shall not be less than $500,000. Notwithstanding anything to the contrary in this
Section 4(a), until the Optional Redemption Price is paid, in full, the Holder may convert all or any part of the outstanding principal amount of this Note, plus accrued interest thereof through the Conversion Date, into a number of Conversion
Shares in accordance with Section 3 hereof. 
 (ii) The Company shall give written notice in respect of an Optional Redemption to each
Holder pursuant to Section 11 at least twenty (20) but not more than thirty (30) days before the date of such Optional Redemption (the “Optional Redemption Date”). In the case of any Optional Redemption of the Notes
in part, the balance of the Notes to be redeemed pursuant to Section 4(a)(i) shall be allocated among all of the Notes at the time outstanding in proportion, as nearly as practicable, to the respective unpaid principal balances thereof. The
Company shall apply any amounts to be used for Optional Redemption pursuant to this Section 4(a), first, to pay accrued and unpaid interest on the Notes, if any, then to redeem the principal amount of the Notes or any portion thereof. Each
notice in respect of an Optional Redemption given pursuant to this Section 4(a)(ii) shall state (A) the Optional Redemption Date, (B) the projected Optional Redemption Price of the Notes to be redeemed, (C) in the case of an
Optional Redemption of the Notes in part, the portion of the outstanding balance of the Notes that is expected to be redeemed and the aggregate balance of Notes to be outstanding after such partial Optional Redemption, (D) that Notes to be
redeemed in an Optional Redemption in whole must be surrendered (which action may be taken by any Holder or its authorized agent) to the Company to collect the Optional Redemption Price on such Notes, and specifying the procedures for such surrender
and (E) that, unless the Company fails to pay the Optional Redemption Price, interest on Notes (or the portion thereof) called for Optional Redemption shall cease to accrue after the Optional Redemption Date. 

  
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 (iii) If notice in respect of an Optional Redemption for any Notes shall have been given as
provided in Section 4(a)(ii), such Notes shall become due and payable on the Optional Redemption Date at the applicable Optional Redemption Price, and, unless there is a default in the payment of the applicable Optional Redemption Price,
interest on such Notes shall cease to accrue on and after such Optional Redemption Date. Upon presentation and surrender of such Notes to the Company in accordance with the notice given pursuant to Section 4(a)(ii), such Notes shall be paid and
redeemed at the applicable Optional Redemption Price on the Optional Redemption Date. 
 (iv) Upon surrender of a Note that is redeemed in
part pursuant to Section 4(a)(i) the Company shall execute for the Holder (at the Company’s expense) a new Note (in a form substantially similar to the form of this Note with appropriate notations for the date of issuance and initial
principal amount) equal in principal balance to the unredeemed portion of the Note surrendered; provided, that the denomination of such Note does not and will not fall below $100,000. 

(v) All Notes that are redeemed pursuant to Section 4(a) will be surrendered to the Issuer for cancellation and may not be reissued or
resold. 
 (b) Mandatory Redemption. 

(i) (A) Cash Flow Sweep Mandatory Redemption. In the event that the Adjusted Consolidated Free Cash Flow for any Fiscal Year is greater
than $100,000, then the Company shall use 50% of such Adjusted Consolidated Free Cash Flow for such Fiscal Year to redeem the Notes, at a redemption price equal to the principal amount of such Notes, plus accrued and unpaid interest thereon through
the Mandatory Redemption Date (such redemption, the “Cash Flow Sweep Mandatory Redemption”); provided that in the event that the Adjusted Consolidated Free Cash Flow for any such Fiscal Year is greater than $50,000,000, then
the Company shall use 75% of such Adjusted Consolidated Free Cash Flow for such Fiscal Year to redeem the Notes at a redemption price equal to the principal amount of such Notes, plus accrued and unpaid interest thereon through the Mandatory
Redemption Date; provided further, that in the event that the Company is required to make any payment of principal or interest on any Loans pursuant to Sections 4(a) of the Facility in respect of such Fiscal Year, such amounts so used to make
such payments pursuant to Sections 4(a) of the Facility shall be deducted from the amounts that the Company is otherwise required to use pursuant to this Section 4(b)(i)(A) to redeem the Notes in respect of such Fiscal Year (but not, for the
avoidance of doubt, in respect of any subsequent Fiscal Year). The amount of Adjusted Consolidated Free Cash Flow to be used to redeem the Notes pursuant to this Section 4(b)(i)(A) is referred to herein as the “Excess Consolidated Free
Cash Flow”. Notwithstanding anything to the contrary in this Note, the amount of any Cash Flow Sweep Mandatory Redemption pursuant to this Section 4(b)(i)(A) in respect of any Fiscal Year shall be payable on the applicable Mandatory
Redemption Date only to the extent that such Cash Flow Sweep Mandatory Redemption, if deducted from the calculation of the Cash Flow Sweep Pro Forma Cash Balance as of the end of such Fiscal Year would not cause such Cash Flow Sweep Pro Forma Cash
Balance to be less than $10 million (or $15 million following the Fiscal Year in which the Indebtedness Repayment Condition has been satisfied but in no event prior to October 1, 2015). 

  
 29 

 (B) Unpaid EACFCF Mandatory Redemption. The amount of any such Excess Adjusted
Consolidated Free Cash Flow that is not payable as of any Mandatory Redemption Date under Section 4(b)(i)(A) as a result of the application of the last sentence of Section 4(b)(i)(A) shall continue to be due and owing (such amount, the
“Unpaid EACFCF”), and the Company shall be obligated to mandatorily redeem the Notes (or portion thereof) on each Mandatory Redemption Date occurring thereafter (until all Unpaid EACFCF shall have been redeemed in full) at a
redemption price equal to such Unpaid EACFCF (or portion thereof) only to the extent that such redemption, if deducted from the calculation of the Cash Flow Sweep Pro Forma Cash Balance as of the end of the applicable Fiscal Year (and after giving
effect to any Cash Flow Sweep Mandatory Redemption payable pursuant to Section 4(b)(i)(A) on such Mandatory Redemption Date) would not cause such Cash Flow Sweep Pro Forma Cash Balance to be less than $10 million (or $15 million following the
Fiscal Year in which the Indebtedness Repayment Condition has been satisfied but in no event prior to October 1, 2015) (such redemption, an “Unpaid EACFCF Mandatory Redemption”). 

(ii) Extraordinary Cash Proceeds Mandatory Redemption. In the event that the Company or any of its Subsidiaries receives any cash or
Cash Equivalents (x) from any third party in connection with the license, distribution or sale of any of the Company’s or any of its Subsidiaries’ products (including if such products are combined or are proposed to be combined with
proprietary technology or products of any other Person), including without limitation, lump-sum payments such as milestone payments, upfront payments or payments made in consideration of reduction of royalty rates (but excluding any such lump-sum
payments from any third party in connection with the license, distribution or sale of the Designated Products and the direct sale by the Company or any of its Subsidiaries of its products (including the Designated Products) to customers or royalty
payments based solely on the percentage of product sales or comparable metrics, in each case in the ordinary course of business of the Company or its Subsidiaries), or (y) outside of the ordinary course of business, but only to the extent
unrelated to the sale, license or distribution of the Designated Products (any such cash or Cash Equivalents described in clause (x) and/or (y) of this Section 4(b)(ii), the “Extraordinary Cash Proceeds”), then the
Company shall use 50% of any such Extraordinary Cash Proceeds to: (A) first, redeem Reimbursement Notes in accordance with Section 4 of the Reimbursement Notes, (B) second, if after giving effect to clause (A) in this
Section 4(b)(ii), the Reimbursement Notes have been redeemed in full, reduce the amount outstanding under the Facility in accordance with Section 4(b) of the Facility, (C) third, if, after giving effect to clause (B) in this
Section 4(b)(ii), the amount outstanding under the Facility, including any Loan outstanding under Section 3(c) of the Facility, has been reduced to zero and there are still Borrowings available to be drawn under Section 2(a) of the
Facility, reduce the future amount of the Commitments under the Facility in accordance with Section 4(b) of the Facility, (D) fourth, if, after giving effect to clause (C) in this Section 4(b)(ii), the amount of the Commitment
has been reduced to zero, redeem the Notes (or portion thereof) at a redemption price equal to the principal amount of such Notes, plus accrued and unpaid interest thereon through the Mandatory Redemption Date (such redemption pursuant to this
subclause (D), the “Extraordinary Cash Proceeds Mandatory Redemption”) and (E) fifth, if after giving effect to clause (D) in this Section 4(b)(ii), the Notes have been redeemed in full, redeem the Bridge Notes in
accordance with Section 4(a) of the Bridge Notes. 

  
 30 

 (iii) Cash Royalty Mandatory Redemption. In the event that (A) any Royalty becomes
due under the Royalty Agreement and is payable in cash in accordance with the terms of the Royalty Agreement, (B) on the date such Royalty becomes due under the Royalty Agreement, no principal or interest is outstanding under the Facility, and
(C) the Royalty rate has been reduced to five percent (5%) in accordance with Section 2.1 and 2.2 of the Royalty Agreement, then the Company shall redeem the Notes (or portion thereof) on the applicable Mandatory Redemption Date at a
redemption price equal to the aggregate amount of such Royalty that has become due and payable pursuant to the Royalty Agreement (such redemption, a “Cash Royalty Mandatory Redemption”), solely to the extent that the cash used for
such Cash Royalty Mandatory Redemption, if deducted from the calculation of the Cash Royalty Pro Forma Cash Balance as of the end of such Fiscal Year or Fiscal Quarter, as applicable, would not cause such Cash Royalty Pro Forma Cash Balance to be
less than $10 million (or $15 million following the Fiscal Quarter in which the Indebtedness Repayment Condition has been satisfied but in no event prior to October 1, 2015). 

(iv) In the case of any Cash Flow Sweep Mandatory Redemption, Unpaid EACFCF Mandatory Redemption, Extraordinary Cash Proceeds Mandatory
Redemption or Cash Royalty Mandatory Redemption (any of such redemptions, a “Mandatory Redemption”) in part, the principal balance of the Notes to be redeemed pursuant to such Mandatory Redemption shall be allocated among all of the
Notes at the time outstanding in proportion, as nearly as practicable, to the respective unpaid balances thereof. The Company shall apply the redemption price pursuant to any Mandatory Redemption (the “Mandatory Redemption Price”),
first, to pay accrued and unpaid interest on the Notes, if any, then to redeem the principal amount of the Notes or any portion thereof. 

(v) Written notice in respect of any Cash Flow Sweep Mandatory Redemption or Unpaid EACFCF Mandatory Redemption shall be given by the Company
to the Holder pursuant to Section 11 within ten (10) days of the end of such Fiscal Year. Written notice in respect of any Extraordinary Cash Proceeds Mandatory Redemption or Cash Royalty Mandatory Redemption shall be given by the Company
to the Holder pursuant to Section 11 at least twenty (20) days before the applicable Mandatory Redemption Date. Each such notice shall state: (A) the Mandatory Redemption Price and Mandatory Redemption Date; (B) in the case of a
Mandatory Redemption of the Notes in part, the portion of the outstanding balance of the Notes that is expected to be redeemed and the aggregate balance of Notes to be outstanding after such partial Mandatory Redemption; (C) that Notes to be
redeemed in whole must be surrendered (which action may be taken by any Holder or its authorized agent) to the Company to collect the Mandatory Redemption Price for such Notes, and specifying the procedures for such surrender, and (D) that,
unless the Company fails to pay the Mandatory Redemption Price, interest on Notes (or the portion thereof) called for Mandatory Redemption shall cease to accrue after the Mandatory Redemption Date. In the case of any Cash Flow Sweep Mandatory
Redemption or Unpaid EACFCF Mandatory Redemption, such notice shall also include a certificate of the Chief Financial Officer of the Company certifying the amount of the Excess Adjusted Consolidated Free Cash Flow and setting out in detail a
calculation thereof. 

  
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 (vi) Notes called for redemption pursuant to Section 4(b) shall become due and payable on
the Mandatory Redemption Date at the applicable Mandatory Redemption Price, and, unless there is a default in the payment of the applicable Mandatory Redemption Price, interest on such Notes shall cease to accrue on and after such Mandatory
Redemption Date. Upon presentation and surrender of such Notes to the Company in accordance with the notice pursuant to Section 4(b)(v), such Notes shall be paid and redeemed at the applicable Mandatory Redemption Price on the Mandatory
Redemption Date. Upon surrender of a Note that is redeemed in part pursuant to Section 4(b), the Company shall execute for the Holder (at the Company’s expense) a new Note (in a form substantially similar to the form of this Note with
appropriate notations for the date of issuance and initial principal amount) equal in principal balance to the unredeemed portion of the Note surrendered. 

(vii) All Notes that are redeemed pursuant to Section 4(b) will be surrendered to the Company for cancellation and may not be reissued or
resold. 
 (viii) Notwithstanding anything to the contrary in this Section 4(b), until the applicable Mandatory Redemption Price is
paid, in full, the Holder may convert all or any part of the outstanding principal amount of this Note, plus accrued interest thereof through the Conversion Date, into a number of Conversion Shares in accordance with Section 3 hereof. 

5. Ranking. This Note shall be senior Indebtedness of the Company, ranking senior to all other Indebtedness and future Indebtedness of
the Company in all respects, including in right of payment in full in cash. 
 6. Representations and Warranties of the Company. The
Company hereby represents and warrants to the Holder, as of the date hereof and each other date required to be made hereunder or under the other Transaction Documents (except to the extent such representations and warranties expressly relate only to
an earlier date, in which case such representations and warranties shall be correct and accurate in all material respects on and as of such earlier date), the following: 

(a) The Company is (i) duly organized, validly existing and in good standing under the laws of the State of Delaware and has all
requisite corporate or similar power and authority to own and operate its properties and assets and to carry on its business as presently conducted, and (ii) qualified to do business and is in good standing as a foreign corporation in each
jurisdiction where the ownership or operation of its properties or conduct of its business requires such qualification, except where the failure to be so qualified would not have a Material Adverse Effect. 

(b) The execution, delivery and performance by the Company of this Note and the other Transaction Documents, and its obligations hereunder and
thereunder, have been duly authorized and have been approved by the board of directors of the Company upon the recommendation of the Special Committee and do not and will not constitute a breach or violation, or constitute a default under, the
organizational documents of the Company; and this Note and each other Transaction Document to be executed by the Company will constitute the valid and legally binding obligation of the Company, enforceable against it in accordance with its terms,
subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicability, relating to or affecting creditors’ rights generally. 

  
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 (c) The execution, delivery and performance by the Company of the Loan Documents do not, and the
performance by it of its obligations contemplated thereunder will not, (i) violate or contravene any provision of the Company’s articles of incorporation, bylaws or similar organizational documents; (ii) except as set forth on
Schedule 6(c)(ii), constitute or result in a breach or violation of, or a default under, the acceleration of any obligations of, or the creation of any Lien on the assets of, the Company or any of its Subsidiaries (with or without notice,
lapse of time or both) pursuant to any contract that is binding upon the Company or any of its Subsidiaries, or any change in the rights or obligations of any party under any of such contracts; (iii) except pursuant to the Loan Documents, and
except as set forth on Schedule 6(c)(iii), require the Company or any of its Subsidiaries to obtain the consent, waiver, authorization or approval of any person which has not already been obtained; or (iv) violate, contravene or conflict
with any award, judgment, decree or other order of any Governmental Authority, any statute, law, rule, regulation or other requirement of any Governmental Authority, or any permit, license, registration or other approval or authorization of any
Governmental Authority. 
 (d) Other than filings to be made in connection with the Security Agreement or pursuant to federal and state
securities laws or filings required to be made with the Over-the-Counter Bulletin Board (the “OTCBB”) directly related to the execution and delivery of the Transaction Documents, no notices, reports or other filings are required to
be made by the Company or any of its Subsidiaries with, nor are any consents, registrations, approvals, permits or authorizations required to be obtained by the Company or any of its Subsidiaries from, any court or Governmental Authority in
connection with the execution and delivery of this Note, the other Loan Documents or the Proposed Transactions. 
 (e) No event has occurred
that could constitute a Default or Event of Default, or could cause a default or event of default to occur, under any agreement or instrument evidencing any Indebtedness of the Company as a result of the issuance of this Note. 

(f) No consent or approval of, or notice to, any creditor of the Company or any Subsidiary (other than the Holder and the “Investor”
under the Investment Agreement) is required by the terms of any agreement or instrument evidencing any Indebtedness of the Company or any Subsidiary for the Company’s execution or delivery of, or the performance of the obligations of the
Company under, this Note or the Loan Documents or the consummation of the transactions contemplated hereby or thereby or the consummation of the other Proposed Transactions. 

(g) There are no (i) except as otherwise disclosed on Schedule 6(g), material civil, criminal or administrative actions, suits,
claims, hearings, investigations or proceedings pending or threatened against the Company or any of its Subsidiaries; or (ii) except as otherwise specifically disclosed in accordance herewith or as otherwise permitted herein, material
obligations or liabilities, whether or not accrued, contingent or otherwise and whether or not required to be disclosed, including those relating to environmental and occupational safety and health matters, or any other facts or circumstances that
could result in any claims against, or obligations or liabilities of, the Company or any of its Subsidiaries. 

  
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 (h) Each of the Company and its Subsidiaries has good and marketable title to, or leasehold
interest in, all real property and other property and assets owned by it, free and clear of all Liens or other encumbrances securing Indebtedness (other than Permitted Liens), and, subject to Section 7(p), its obligations under both this Note
and the other Loan Documents rank senior to all other existing Indebtedness and future Indebtedness of the Company in all respects, including in right of payment in full in cash. 

(i) The Company’s (i) audited financial statements as of December 31, 2013 and for the Fiscal Year ended on that date; and
(ii) consolidated balance sheet dated as of June 30, 2014 and the related Income Statements and Cash Flow Statements for the portion of the Fiscal Year ended on that date, each as heretofore delivered to the Holder are complete and
correct, have been prepared in accordance with GAAP. The audited financial statements of the Company as of December 31, 2013 and for the Fiscal Year ended on that date have been certified by a firm of independent accountants as fairly
presenting the financial condition of the Company as at that date and the results of its operations for that Fiscal Year or portion thereof. 

(j) Since December 31, 2013, there has not been (i) any material damage, destruction or other casualty loss with respect to any
material asset or property owned, leased or otherwise used by the Company or any of its Subsidiaries, whether or not covered by insurance; (ii) any declaration, setting aside or payment of any dividend or other distribution in respect of the
capital stock of the Company; or (iii) any change by the Company or any of its Subsidiaries in accounting principles, practices or methods. 

(k) The Company has filed all required reports, schedules, registration statements and other documents with the SEC since April 30, 2002.
The Company’s annual reports on Form 10-K, quarterly reports on Form 10-Q and all other reports, registration statements, definitive proxy statements or information statements, including any certifications pursuant to Section 302 or
Section 906 of the Sarbanes-Oxley Act of 2002 or similar certifications, filed by the Company or any Subsidiary subsequent to April 30, 2002, under the Securities Act or under Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act in the
form filed (collectively, the “Company SEC Documents”), with the SEC, (i) complied in all material respects as to form with the applicable requirements under the Securities Act or the Exchange Act, as the case may be; and
(ii) as of its filing date, did not or will not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements made therein, in light of the circumstances under
which they were made, not misleading; and each of the balance sheets contained in or incorporated by reference into any such Company SEC Document (including the related notes and schedules thereto) fairly presents or will fairly present the
financial position of the entity or entities to which it relates as of its date, and each of the Income Statements and Cash Flow Statements or equivalent statements in such Company SEC Documents (including any related notes and schedules thereto)
fairly presents or will fairly present the results of operations, changes in stockholders’ equity and changes in cash flows, as the case may be, of the entity or entities to which it relates for the periods to which it relates, in each case in
accordance with GAAP consistently applied during the periods involved, except, in each case, as may be noted therein, subject to normal year-end audit adjustments in the case of unaudited statements. 

  
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 (l) The Company has designed and maintains a system of internal controls over financial reporting
(as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) sufficient to provide reasonable assurances regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with GAAP.
The Company (i) has designed and maintains disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act) to ensure that material information required to be disclosed by the Company in the reports that it
files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms and is accumulated and communicated to the Company’s management as appropriate to allow
timely decisions regarding required disclosure; and (ii) has disclosed, based on its most recent evaluation of such disclosure controls and procedures prior to the date of this Note, to the Company’s auditors and the audit committee of the
Board of Directors (A) any significant deficiencies and material weaknesses in the design or operation of internal controls over financial reporting that are reasonably likely to adversely affect in any material respect the Company’s
ability to record, process, summarize and report financial information; and (B) any fraud, whether or not material, that involves management or other employees who have a significant role in the Company’s internal controls over financial
reporting. 
 (m) Since January 1, 2012, the Company has not received written notice from the SEC or any other Governmental Authority
that any of its accounting policies or practices, or any of the documents filed by the Company or filed or furnished by its officers, are or may be the subject of any review, inquiry, investigation or challenge by the SEC or other Governmental
Authority, other than comments received by the Company from the SEC in connection with periodic reports filed by the Company under the Exchange Act or registration statements filed by the Company under the Securities Act, which comments are resolved
prior to the due date for filing the Company’s next annual report on Form 10-K. Since January 1, 2012, neither the Company’s independent public accounting firm, nor any employee, director, advisor or other agent or Affiliate of the
Company has informed the Company that such Person has any material questions, challenges or disagreements regarding or pertaining to the Company’s accounting policies or practices or the Company’s internal controls over financial
reporting. 
 (n) Schedule 6(n) contains a true and complete list of, and the Company has delivered to the Holder copies of all
documents creating or governing, all securitization transactions and “off-balance sheet arrangements” (as defined in Item 303(a)(4)(ii) of Regulation S-K of the SEC) effected by or to which the Company is a party since January 1,
2004. 
 (o) Except as set forth on Schedule 6(o), the Company has not, since July 30, 2002, extended or maintained credit,
arranged for the extension of credit, or renewed an extension of credit, in the form of a personal loan to or for any director or executive officer (or equivalent thereof) of the Company or any Affiliate. 

(p) To the Knowledge of the Company, McGladrey & Pullen LLP and PricewaterhouseCoopers LLP, which have expressed their opinions with
respect to the financial statements of the Company audited by them and included in the Company SEC Reports (including the related notes), is and has been throughout the period covered by such financial statements, (i) a registered public
accounting firm (as defined in Section 2(a)(12) of the Sarbanes-Oxley Act); (ii) “independent” with respect to the Company within the meaning of Rule 2-01 of Regulation S-X of the SEC; (iii) in compliance with subsections
(g) through (l) of Section 10A of the Exchange Act and the related Rules of the SEC; and (iv) in compliance with the rules of the Public Company Accounting Oversight Board. Schedule 6(p) contains a true and complete list
of all non-audit services performed by PricewaterhouseCoopers LLP for the Company from November 1991 until January 2010 and McGladrey & Pullen LLP since January 2010. 

  
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 (q) The execution and delivery of this Note and the other Loan Documents is not subject to any
tax, duty, fee or other charge, including, without limitation, any registration or transfer tax, stamp duty or similar levy. 
 (r)
(i) Schedule 6(r) lists all Plans and separately identifies all Pension Plans, Multiemployer Plans and Welfare Plans, including all Retiree Welfare Plans as of the date hereof. Copies of all such listed Plans, together with a copy of the
most recently filed Form IRS/DOL 5500 for each such Plan have been made available to the Holder prior to the date hereof. Except with respect to Multiemployer Plans, each Qualified Plan has been determined by the IRS to qualify under
Section 401 of the IRC, the trusts created thereunder have been determined to be exempt from tax under the provisions of Section 501 of the IRC, and, to the Knowledge of the Company, nothing has occurred that would cause the loss of such
qualification or tax-exempt status. Each Plan is in material compliance with the applicable provisions of ERISA and the IRC, including the timely filing of all reports required under the IRC or ERISA, including the statement required by 29 CFR
Section 2520.104-23. Neither the Company, nor any Subsidiary, nor any ERISA Affiliate has failed to make any material contribution or pay any amount due as required by either Section 412 of the IRC or Section 302 of ERISA or the terms
of any Plan. Neither the Company, nor any Subsidiary, nor any ERISA Affiliate has engaged in a “prohibited transaction,” as defined in Section 406 of ERISA and Section 4975 of the IRC, in connection with any Plan, that would
subject the Company or any Subsidiary to a material tax on prohibited transactions imposed by Section 502(i) of ERISA or Section 4975 of the IRC. 

(ii)(A) Except as disclosed on Schedule 6(r), neither the Company, nor any Subsidiary, nor any ERISA Affiliate has ever maintained,
established, sponsored, participated in or contributed to any Title IV Plan; (B) there are no pending, or to the Knowledge of the Company or any Subsidiary, threatened claims (other than claims for benefits in the normal course), sanctions,
actions or lawsuits, asserted or instituted against any Plan or any Person as fiduciary or sponsor of any Plan; and (C) neither the Company, nor any Subsidiary, nor any ERISA Affiliate has incurred or reasonably expects to incur any liability
as a result of a complete or partial withdrawal from a Multiemployer Plan. 
 (s) The Company’s use, storage, treatment and disposal of
Hazardous Substances is and has been in full compliance with Environmental Law; (i) there has been no unpermitted release, discharge, emission or escape into the environment of Hazardous Substances caused by the Company or any of its
Subsidiaries; (ii) the Company has all permits necessary and required for its use, storage, treatment and disposal of Hazardous Substances; and (iii) the Company does not know of, and has not received, any written notice or other
communication from any person or entity (including but not limited to a Governmental Authority) of a possible claim or liability pursuant to any Environmental Law, or any actual or potential administrative or judicial proceedings in connection with
any of the foregoing. 

  
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 (t) (i) The Company owns, either exclusively or jointly, all right, title and interest in
and to (free and clear of all Liens other than Permitted Liens) or is licensed to use all the Company Intellectual Property, including, without limitation, the Patents, Trademarks and Copyrights listed on Schedule 6(t), and, except as set
forth on Schedule 6(t), has exclusive rights to use, sell, license, assign, transfer, convey, dispose of, or otherwise commercially exploit the Company Intellectual Property. 

(ii) Schedule 6(t) lists all of the Company’s Patents, Trademarks, registered Copyrights and material Know-How, and, to the extent
applicable, the jurisdiction(s) in which each item of Company Intellectual Property was or is filed or registered, including the respective application or registration numbers and dates, and an indication as to whether each such item of Company
Intellectual Property is owned exclusively or jointly. Each item of Company Intellectual Property is in compliance with all formal legal requirements (including payment of filing, examination, annuity and maintenance fees and proofs of use) and is
valid and subsisting. In connection with all Company Intellectual Property owned, either exclusively or jointly by the Company, the Company represents and warrants, and in connection with all third-party Company Intellectual Property, the Company
represents and warrants to Company’s Knowledge, that all necessary registration, maintenance and renewal fees have been paid and all necessary documents and certificates in connection with such Company Intellectual Property have been filed with
the relevant patent, copyright, trademark or other authorities in the United States or foreign jurisdictions, as the case may be, for the purposes of perfecting, prosecuting and maintaining such Company Intellectual Property. 

(iii) The operation of the business of the Company as currently conducted or currently contemplated to be conducted does not and will not
infringe or misappropriate the Intellectual Property of any third party, violate any right of any third party or constitute unfair competition or trade practices under the laws of any jurisdiction. 

(iv) Other than as described in Schedule 6(t), no Person has asserted or threatened to assert any claims (A) contesting the right
of the Company to use, exercise, sell, license, transfer or dispose of any Company Intellectual Property or any products, processes or materials covered thereby in any manner; or (B) challenging the ownership, validity or enforceability of any
Company Intellectual Property. No owned Company Intellectual Property and, to the Company’s Knowledge, no third-party Company Intellectual Property is subject to any outstanding order, judgment, decree, stipulation or agreement related to or
restricting in any manner the licensing, assignment, transfer, use or conveyance thereof by the Company. 
 (v) The Company has not received
any written notice or otherwise has Knowledge of any pending or threatened claim, order or proceeding with respect to any Company Intellectual Property and, to the Company’s Knowledge, no Company Intellectual Property is being used or enforced
in a manner that would reasonably be expected to result in the abandonment, cancellation or unenforceability of such Intellectual Property. 

  
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 (vi) The Company has required all professional and technical employees who provided services to
the Company in connection with the Company Intellectual Property to execute agreements under which such employees are and were required to convey to the Company ownership of all inventions and developments conceived or created by them in the course
of their employment with the Company. To the Company’s Knowledge, none of the activities of the Company’s professional and technical employees who are providing services to the Company in connection with the Company Intellectual Property
is violating any agreement between any such employees and their former employers. 
 (vii) Other than as described in Schedule 6(t),
the Company has not received any opinion of counsel regarding any third party Intellectual Property or any owned Company Intellectual Property. 

(viii) To the Company’s Knowledge, the Company has complied with its obligation under 37 CFR § 1.56(a) to disclose to the United
States Patent and Trademark Office, during the pendency of any United States patent application comprising the owned Company Intellectual Property. None of the Company’s Patents is involved in any interference or opposition proceeding, and, to
the Company’s Knowledge, no such proceeding is being threatened with respect to any of the Patents. 
 (ix) To the extent that any
Intellectual Property has been developed or created independently or jointly by an independent contractor or other third party for the Company, or is incorporated into any of the Company products, the Company has a written agreement with such
independent contractor or third party and Company thereby has obtained exclusive or joint ownership of all such independent contractor’s or third party’s Intellectual Property in such work, material or invention by operation of law or
valid assignment, or has acquired rights sufficient to use such Intellectual Property in the business of the Company as currently conducted and as contemplated to be conducted by virtue of a license. 

(x) Schedule 6(t) lists all agreements pertaining to Company Intellectual Property including without limitation, agreements pursuant to
which the Company either receives or grants rights in Intellectual Property. The Company is, and will be, in compliance with all terms and conditions of all, and is not and will not be in violation of any, licenses, sublicenses and other agreements,
relating to Intellectual Property to which it is a party, whether acquiring or granting rights, or otherwise. Except as set forth in Schedule 6(t), the Company has no Knowledge of any assertion, claim or threatened claim, or facts that could
serve as a basis of any assertion or claim, that the Company has breached or defaulted on any terms or conditions of such licenses, sublicenses and other agreements, and the Company has no basis to believe that any other party to such licenses,
sublicenses and other agreements is in breach or in default of any terms or conditions thereof. 
 (xi) The Company has disclosed trade
secrets of the Company included in the Know-How only to Persons that have executed written confidentiality agreements governing the use or disclosure of such trade secrets, except to the extent the Company disclosed such information in connection
with making filings related to any Company Intellectual Property with Governmental Authorities. 

  
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 (xii) The Company has taken all reasonably prudent or necessary steps to protect and preserve the
confidentiality of its material Confidential Information, and with respect to all other Confidential Information the Company has taken all commercially reasonable steps to protect and preserve the confidentiality of such Confidential Information.
Without limiting the foregoing, the Company has and enforces a policy requiring each employee and consultant of the Company to execute a proprietary rights and confidentiality agreement, and all current and former employees and consultants of the
Company have executed such an agreement. 
 (xiii) Except as set forth on Schedule 6(t)(xiii), the Company has not received any
adverse written notice from the FDA or any other Authority since January 1, 2011 (i) regarding the approvability of product candidates of the Company or (ii) alleging any violation of any law, policy, guideline, rule or regulation by
the Company. Schedule 6(t)(xiii) sets forth (i) all of the Company’s regulatory correspondence received from the FDA or any other similar Authority since January 1, 2011, which correspondence has been provided to the Holder and
(ii) all of the permits issued to the Company by the FDA or any other similar Authority. During the last five years no officer, employee or agent of the Company, has made an untrue statement of a material fact or fraudulent statement to the FDA
or any other authority, failed to disclose a material fact required to be disclosed to the FDA or any other authority, or committed an act, made a statement, or failed to make a statement that, at the time such disclosure was made which would
violate any law, policy, guideline, rule or regulation. 
 (u) The provisions of the Security Documents are effective to create in favor of
the Holder a legal, valid and enforceable lien and security interest in all right, title and interest of the Company in the “Collateral” described therein. Upon the filing of proper financing statements in the offices in the jurisdictions
listed on Schedule 6(u), the Holder shall have a perfected first priority security interest or lien on all right, title and interest of the Company in the “Collateral” described therein, which can be perfected by such filing,
subject only to the existence of any Permitted Liens. 
 (v) The businesses of the Company and its Subsidiaries have not been, and are not
being, conducted in violation of any material state, local, federal, foreign or domestic laws, rules, regulations or court orders and none of the transactions contemplated in this Note or the other Loan Documents (including, without limitation, the
borrowing hereunder and the use of the proceeds thereof), or the Proposed Transactions, will violate or result in a violation of Section 7 of the Exchange Act, or any regulations issued pursuant thereto, including, without limitation,
Regulations G, T, U and X of the Board of Governors of the Federal Reserve System, 12 C.F.R., Chapter II. 
 (w) The written materials
delivered or caused to be delivered, by or on behalf of the Company, to the Holder in connection with this Note and the other Loan Documents and the other transactions contemplated by this Note do not contain any untrue statement of a material fact
or omit to state a material fact necessary in order to make the statements contained therein, in light of the circumstances under which they were made, not misleading. 

(x) The Company and its Subsidiaries have filed, or caused to be filed, in a timely manner, or are on a valid extension for filing with
respect to, all federal, state and other tax returns and reports required to be filed, and have paid, in a timely manner, all federal, state and other taxes, assessments, fees and other governmental charges levied or imposed upon them or their
properties, income or assets otherwise due and payable. All information in such tax returns, reports and declarations is true, complete and correct in all respects. 

  
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 (y) To the best Knowledge of the Company, since the date three years prior to the Closing Date,
the Company has not undergone an “ownership change” as such term is defined for purposes of Section 382 of the IRC, and the Treasury Regulations (final, temporary and, as applicable, proposed) promulgated thereunder (an
“Ownership Change”). 
 (z) Set forth on Schedule 6(z) is a list, as of the date hereof, of all of the real property
interests held by the Company and its Subsidiaries, indicating in each case whether the respective property is owned or leased, the identity of the owner or lessee and the location of the respective property. 

(aa) As of the date hereof, the authorized capital stock of the Company consists of (i) 200,000,000 shares of Common Stock of which
60,687,478 shares were issued and outstanding, of which 289,732 are held as treasury shares; and (ii) 2,000,000 shares of preferred stock, par value $.01 per share, of which no shares were issued and outstanding. Each of the outstanding shares
of capital stock or other securities of each of the Subsidiaries is duly authorized, validly issued, fully paid and nonassessable and owned by the Company or by a direct or indirect wholly owned Subsidiary of the Company, free and clear of any
Liens, other than Permitted Liens. Except as set forth in Schedule 6(aa), there are no preemptive or other outstanding rights, options, warrants, conversion rights, stock appreciation rights, redemption rights, repurchase rights, agreements,
arrangements or commitments to issue or sell any shares of capital stock or other securities of the Company or any Subsidiary or any securities or obligations convertible or exchangeable into or exercisable for, or giving any Person a right to
subscribe for or acquire, any securities of the Company or any Subsidiary, and no securities or obligations evidencing such rights are authorized, issued or outstanding. 

(bb) The Company and its Subsidiaries are insured by recognized, financially sound and reputable institutions with policies in such amounts
and with such deductibles and covering such risks as are generally deemed adequate and customary for its businesses including, but not limited to, policies covering real and personal property owned or leased by the Company against theft, damage,
destruction and acts of vandalism, and complying with the requirements set forth in Section 7(j) hereof. The Company has no reason to believe that it or any Subsidiary will not be able (i) to renew its existing insurance coverage as and
when such policies expire or (ii) to obtain comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a cost that would not have a Material Adverse Effect. 

7. Covenants. 
 (a)
Governmental Authorizations. The Company shall obtain, make and keep in full force and effect all authorizations from and registrations with Governmental Authorities that may be required for the validity or enforceability against the Company
of this Note and the other Loan Documents. 

  
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 (b) Financial Statements; Reporting. (i) The Company shall furnish to the Holder,
within 45 days of the close of each of the first 3 Fiscal Quarters of each Fiscal Year, its consolidated and consolidating balance sheets as at the close of such Fiscal Quarter and its income statement and statement of changes in financial position
for such Fiscal Quarter , prepared in accordance with GAAP, applied on a basis consistent with that used in preparing its audited financial statements for prior years, certified by its chief financial officer as fairly presenting the financial
condition of the Company and its Subsidiaries as at the close of that Fiscal Quarter and the results of its operations for such Fiscal Quarter, subject to changes resulting from audit and normal year-end adjustments. 

(ii) The Company shall furnish to the Holder, within 90 days of the close of each Fiscal Year commencing with the Fiscal Year ending
December 31, 2014, its consolidated and consolidating balance sheets as at the close of such Fiscal Year and its income statement and statement of changes in financial position for such Fiscal Year, prepared in accordance with GAAP, applied on
a basis consistent with that used in preparing its audited financial statements for prior years, certified by a firm of independent accountants selected by it and acceptable to the Holder as fairly presenting the financial condition of the Company
and its Subsidiaries as at the close of such Fiscal Year and the results of its operations for such Fiscal Year. The certification shall include or be accompanied by a statement that, during the examination by that firm of those financial
statements, that firm observed or discovered no Default or Event of Default (or a detailed description of any Default or Event of Default so observed or discovered). 

(iii) The Company shall furnish to the Holder, not later than November 30 of each year a revised annual operating budget, which in any
case, upon review and written approval of the Holder (which approval shall not be unreasonably withheld), shall thereafter constitute the Budget. 

(iv) The Company shall deliver to the Holder on the first Business Day of each month, a compliance certificate certifying that (1) no
Default or Event of Default has occurred and is continuing, and (2) the representations and warranties of the Company set forth in this Note and in each other Loan Document are true and correct as if made on such date (except for
representations made as of a specified earlier date, which shall remain true as of such earlier date). A form of such compliance certificate is attached hereto as Exhibit C. 

(v) The Company shall furnish to the Holder not later than the 15th day of each month a variance report detailing any variances from the
Budget during the previous month. 
 (vi) The Company shall furnish to the Holder from time to time such other statements and information as
the Holder may reasonably request. 
 (vii) Promptly upon the resignation of any person from the Board of Directors, the Company shall
provide the Holder with a copy of the resignation letter of such person, together with any waiver letters, indemnity agreements and other documents or instruments executed or delivered in connection with such resignation. 

(c) ERISA. The Company and its Subsidiaries shall not, and shall not cause or permit any ERISA Affiliate to, cause or permit to occur
an ERISA Event. The Company and its Subsidiaries shall not, and shall not cause or permit any ERISA Affiliate to, adopt, sponsor, maintain or contribute to any Title IV Plan. 

  
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 (d) Maintenance of Property. The Company shall keep all property useful and necessary in
its business in good working order and condition, ordinary wear and tear excepted. 
 (e) Maintenance of Existence; Lines of
Business. The Company shall preserve, renew and keep in full force and effect its corporate existence and its rights, privileges, franchises and licenses (including, but not limited to, licenses required by the FDA and other applicable agencies)
necessary or desirable in the normal conduct of its business. The Company shall not be engaged in any line of business other than the Line of Business. 

(f) Compliance with Laws. The Company shall comply in all respects with all applicable laws, ordinances, rules, regulations, and
requirements of Governmental Authorities (including, without limitation, Environmental Laws, Tax laws, and ERISA and the rules and regulations promulgated thereunder). 

(g) Books and Records; Inspection Rights. The Company shall keep proper books and records in which full, true and correct entries are
made of all dealings and transactions in relation to its business and activities. The Company shall permit the Holder and representatives of the Holder to inspect its property, books and records at any reasonable times, and to make copies of such
books and records as the Holder (or its representative) shall desire. 
 (h) Notices of Default. The Company shall promptly notify
the Holder of each Default or Event of Default, and each other event that has or could have a materially adverse effect on its ability to perform its obligations under this Note or another Loan Document, together with a detailed description of such
Default, Event of Default or other event, and all actions taken or to be taken in response thereto. 
 (i) Liens and Encumbrances.
The Company shall not create or permit to be created or exist any Lien on any of its property now owned or hereafter acquired, other than Permitted Liens. 

(j) Insurance. The Company shall maintain, with financially sound and reputable insurance companies, insurance in such amounts and
against such risks as are customarily maintained by companies engaged in the same or similar businesses operating in the same or similar locations. The Company will in any event maintain: 

(i) Casualty Insurance against loss or damage covering all of the tangible real and personal property and improvements of the Company by
reason of any Peril in such amounts (subject to such deductibles as shall be satisfactory to the Holder) as shall be reasonable and customary and sufficient to avoid the insured named therein from becoming a co-insurer of any loss under such policy
but in any event in an amount (i) in the case of fixed assets and equipment (including vehicles), at least equal to 100% of the actual replacement cost of such assets (including foundation, footings and excavation costs), subject to deductibles
as aforesaid; and (ii) in the case of inventory, not less than the fair market value thereof, subject to deductibles as aforesaid. 

  
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 (ii) Automobile liability insurance against liability for bodily injury and property damage in
respect of all vehicles (whether owned, hired or rented by the Company) at any time located at, or used in connection with, its properties or operations in such amounts as are then customary for vehicles used in connection with similar properties
and businesses, but in any event to the extent required by applicable law. 
 (iii) Comprehensive general liability insurance against claims
for bodily injury, death or property damage occurring on, in or about the properties (and adjoining streets, sidewalks and waterways) of the Company, in such amounts as are then customary for property similar in use in the jurisdictions where such
properties are located. 
 (iv) Workers’ compensation insurance (including Employers’ Liability Insurance) to the extent required
by applicable law. 
 (v) Product liability insurance against claims for bodily injury, pain and suffering, death or property damage
resulting from the use of products developed, tested or sold by the Company in such amounts as are then customarily maintained by responsible persons engaged in businesses similar to that of the Company. 

(vi) Other insurance as generally carried by owners of similar properties and businesses, in such amounts and against such risks as are then
customary for property similar in use. 
 Such insurance shall name the Holder as loss payee (to the extent covering risk of loss or damage
to tangible property) and as an additional named insured as its interests may appear (to the extent covering any other risk). Each policy referred to in this Section shall provide that it will not be canceled or reduced, or allowed to lapse without
renewal, except after not less than 30 days’ notice to the Holder. The Company will advise the Holder promptly of any policy cancellation, reduction or amendment. Any proceeds received by the Holder on account of any such insurance policy
referred to in this Section 7(j) shall be applied by the Holder promptly to reduce the outstanding amount of the Obligations then due and payable. 

Without limiting the obligations of the Company under the foregoing provisions of this Section, in the event the Company shall fail to
maintain in full force and effect insurance as required by the foregoing provisions of this Section, then the Holder may, but shall have no obligation so to do, procure insurance covering the interests of the Holder in such amounts and against such
risks as the Holder shall deem appropriate, and the Company shall reimburse the Holder in respect of any premiums paid by the Holder in respect thereof. 

(k) Consolidations, Mergers. The Company shall not, directly or indirectly, by operation of law or otherwise, merge with or consolidate
with another Person, liquidate, windup or dissolve itself, or sell, transfer or lease or otherwise dispose of all or any substantial part of its assets or acquire by purchase or otherwise the business or assets of, or stock of, another Person;
except (i) that any Subsidiary may merge into or consolidate with any other Subsidiary; and (ii) any Subsidiary may merge with or consolidate into the Company; provided that the Company is the surviving organization. 

  
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 (l) Asset Sales. The Company shall not, and shall not permit any Subsidiary to, without
the prior written consent of the Holder (which shall not be unreasonably withheld) directly or indirectly, consummate any Asset Sale. 
 (m)
Transactions With Affiliates. The Company shall not, and shall not permit any of its Subsidiaries to, make any payment to, or sell, lease, transfer or otherwise dispose of any of its properties or assets to, or purchase any property or assets
from, or enter into, make or amend any transaction, contract, agreement, understanding, loan, advance or guarantee with, or for the benefit of, any Affiliate (each of the foregoing, an “Affiliate Transaction”), unless (i) such
Affiliate Transaction is on terms that are no less favorable to the Company or such Subsidiary than those that would have been obtained in a comparable transaction by the Company or such Subsidiary with an unrelated Person; and (ii) with
respect to any Affiliate Transaction or series of related Affiliate Transactions involving aggregate consideration in excess of $500,000, the Company delivers to the Holder a resolution of the Board of Directors certifying that such Affiliate
Transaction complies with clause (i) above and that such Affiliate Transaction has been approved by a majority of the disinterested members of the Board of Directors, and an opinion as to the fairness to the Company or such Subsidiary of such
Affiliate Transaction from a financial point of view issued by an accounting, appraisal or investment banking firm of national standing. Notwithstanding the foregoing, the following items shall not be deemed to be Affiliate Transactions:
(A) the payment of reasonable directors’ fees to Persons who are not otherwise Affiliates of the Company or indemnification and similar arrangements, consulting fees, employee salaries, bonuses, employment agreements, compensation or
employee benefit arrangements or incentive arrangements with any officer, director or employee of the Company or any Subsidiary (including benefits under the foregoing); (B) Restricted Payments made in compliance with Section 7(q);
(C) loans or advances to employees and reimbursement of actual out-of-pocket expenses incurred by officers, directors and employees, in each case in the ordinary course of business in an amount not to exceed $100,000 individually and $200,000
in the aggregate during any Fiscal Year; and (D) the Proposed Transactions. 
 (n) Notice of Tax Exemption. If an exemption is
obtained at any time from any present or future Taxes that would otherwise be due in respect of any payment to be made by the Company under this Note or any other Loan Document, the Company shall promptly deliver to the Holder a certified copy of
the documents evidencing that exemption. 
 (o) Payment of Taxes. The Company shall pay all Taxes, assessments and other governmental
charges of any kind imposed on or in respect of its income or any of its businesses or assets, or in respect of Taxes and other amounts it is required by law to withhold from amounts paid by it to its employees, before any penalty or interest
accrues on the amount payable and before any Lien or other encumbrance on any of its property exists as a result of nonpayment; provided, however, that the Company shall not be required by this Section to pay any amount if it is
diligently contesting its alleged obligation to pay that amount in good faith through appropriate proceedings and maintains appropriate reserves or other provisions in respect of the contested amount as may be required under GAAP. 

(p) Limitation on Indebtedness. The Company and its Subsidiaries, on a consolidated basis, shall not directly or indirectly incur,
create, assume, guarantee, become liable, contingently or otherwise, with respect to, or otherwise become responsible for the payment of, including, without limitation, by way of assumption or acquisition in a business combination any Indebtedness
other than (i) pursuant to this Note, the other Loan Documents, the Investment Agreement or the other Transaction Documents; (ii) any Indebtedness that is by its terms expressly subordinated in all respects to the Obligations, on terms and
conditions satisfactory to the Holder, in its sole discretion; and (iii) Indebtedness secured by Permitted Liens. 

  
 44 

 (q) Restricted Payments. The Company shall not, and shall not permit any Subsidiary,
directly or indirectly, to make a Restricted Payment other than, so long as no Event of Default shall have occurred and be continuing, or shall result therefrom, (i) any Restricted Payment made out of the Net Cash Proceeds of the substantially
concurrent sale of, or made by exchange for, Equity Interests of the Company (other than Disqualified Equity Interests and other than Equity Interests issued or sold to a Subsidiary of the Company or an employee stock ownership plan or to a trust
established by the Company or any of its Subsidiaries for the benefit of their employees) or a substantially concurrent capital contribution received by the Company from its stockholders; or (ii) any purchase, repurchase, redemption, defeasance
or other acquisition or retirement for value of Indebtedness of the Company or any Guarantor that is subordinated to the Obligations, made by exchange for, or out of the proceeds of the substantially concurrent sale of, Indebtedness of the Company;
provided, that such newly issued Indebtedness is subordinated to the Obligations on the same terms as the Indebtedness so purchased, repurchased, redeemed, defeased, acquired or retired. 

(r) Notices. The Company shall promptly give notice to the Holder of: (i) any change in the Company or its operations that would
adversely affect the interests of the Holder in any material respect; (ii) any default by the Company in its obligations under the documentation governing any Indebtedness; (iii) any breach by the Company of any other contract;
(iv) any litigation involving the Company or a Subsidiary; (v) any material governmental notifications and proceedings, including approval and denial notices by the FDA; (vi) any Person which has become a 5-percent stockholder, as
such term is defined for purposes of Section 382 of the IRC and the Treasury Regulations (final, temporary and, as applicable, proposed) promulgated thereunder and (vii) any other development that causes or could reasonably be expected to
cause a Material Adverse Effect. 
 (s) Cancellation of Indebtedness. The Company shall not cancel any claim or debt owing to it,
except for reasonable consideration negotiated on an arm’s length basis and in the ordinary course of its business consistent with past practices and settlement of accounts in the ordinary course of business. 

(t) Subsidiaries. Neither the Company nor any Subsidiary shall acquire or create another Subsidiary without the prior consent of the
Holder, and such newly acquired or created Subsidiary shall promptly execute a Subsidiary Guaranty and a Subsidiary Security Agreement, and such other documents and such other documents and instruments as the Holder may reasonably require, and the
Company or such Subsidiary acquiring or creating such new Subsidiary shall pledge the stock of the newly acquired or created Subsidiary as Collateral. 

(u) Limitation on Issuance of Equity Interests of Subsidiaries. The Company shall not sell, and shall not permit any Subsidiary,
directly or indirectly, to issue or sell, any shares of Equity Interests of a Subsidiary (including options, warrants, or other rights to purchase shares of such Equity Interests) except: (i) to the Company or a wholly owned Subsidiary of the
Company; or (ii) issuances of director’s qualifying shares or sales to foreign nationals of shares of Equity Interests of foreign Subsidiaries, to the extent required by applicable law. 

  
 45 

 (v) Maintenance of NOLs. Neither the Company, any Subsidiary nor any Affiliate of any
thereof, shall enter into any transaction which could reasonably be expected to cause the Company, any Subsidiary or any Affiliate of any thereof to undergo an Ownership Change, other than an Excepted Transaction. For purposes of this
Section 7(v), “Excepted Transaction” shall mean (a) any transaction contemplated under the Restructuring Agreement, the Loan Agreement, this Note, the other Loan Documents, the Investment Agreement, the Registration Rights
Agreement and any other certificate, instrument, agreement or other document executed or to be executed in connection therewith, and (b) any other financing transaction undertaken or to be undertaken by the Company (i) with the prior
written consent of the Holder (such consent not to be unreasonably withheld or delayed), or (ii) with respect to which the Board of Directors has considered the effect of such proposed financing transaction on the availability to the Company,
any Subsidiary or any Affiliate of any thereof of net operating losses or associated tax benefits pursuant to Section 382 of the IRC arising from or related to such proposed financing transaction, and obtained the advice of outside counsel or
accountants that such transaction has been structured to minimize any negative effect on the availability of such net operating losses or associated tax benefits. For the avoidance of doubt, and notwithstanding anything to the contrary herein, any
change in the availability of net operating losses arising from or related to any Excepted Transactions shall not constitute a breach of or a Default or an Event of Default under this Note. 

(w) Intellectual Property. (i) The Company shall conduct continuously and operate actively its business according to good business
practices, including, without limitation, maintaining all of its licenses, Patents, Copyrights, Know-How, design rights, trade names, trade secrets and trademarks and taking all actions necessary to enforce and protect the validity and
enforceability of all intellectual property rights or other right included in the Company Intellectual Property. 
 (ii) The Company (either
itself or through licensees) will not do any act, or omit to do any act, whereby any of its Patents may become forfeited, abandoned or dedicated to the public, unless the Holders give their prior written consent, which shall not be unreasonably
withheld or delayed. 
 (iii) The Company (either itself or through licensees) will continue to use each of its Trademarks in order to
maintain such Trademark in full force free from any claim of abandonment for non-use, unless the Holders give their prior written consent, which shall not be unreasonably withheld or delayed. 

(iv) The Company will not (either itself or through licensees) do any act whereby any of its Copyrights may fall into the public domain,
unless the Holders give their prior written consent, which shall not be unreasonably withheld or delayed. 

  
 46 

 (v) The Company (either itself or through licensees) will not infringe the Intellectual Property
rights of any other Person. 
 (vi) The Company will notify the Holder immediately if it knows, or has reason to know, that any application
or registration relating to any Company Intellectual Property may become forfeited, abandoned or dedicated to the public, or of any adverse determination or development (including the institution of, or any such determination or development in, any
proceeding in the United States Patent and Trademark Office, the United States Copyright Office or any agency, court or tribunal in any country) regarding, the Company’s ownership of, or the validity of, or the enforceability of, any Company
Intellectual Property or the Company’s right to register the same or to own and maintain the same. 
 (vii) Whenever the Company,
either by itself or through any agent, employee, licensee or designee, shall file an application for the registration of any Intellectual Property with the United States Patent and Trademark Office, the United States Copyright Office or any similar
office or agency in any other country or any political subdivision thereof, the Company shall promptly report such filing to the Holder. Upon the request of the Holder, the Company shall execute and deliver to the Holder, any and all agreements,
instruments, documents, and papers as the Holder may reasonably request to evidence the Holder’s security interest in any Copyright, Patent or Trademark and the goodwill and general intangibles of the Company relating thereto or represented
thereby. 
 (viii) The Company will take all reasonable and necessary steps to maintain and pursue each application (and to obtain the
relevant registration) and to maintain each registration of all Company Intellectual Property owned by it. 
 (ix) In the event that any
Company Intellectual Property is infringed upon or misappropriated or diluted by a third party, the Company shall (i) take such actions as reasonably necessary to protect such Company Intellectual Property; and (ii) promptly notify the
Holder after the Company learns thereof and, to the extent, in its reasonable judgment, the Company determines it appropriate under the circumstances, sue for infringement, misappropriation or dilution, to seek injunctive relief where appropriate
and to recover any and all damages for such infringement, misappropriation or dilution. 
 (x) Investments. The Company shall not
make or permit to remain outstanding any Investments except: 
 (i) Investments outstanding on the date hereof and identified in Schedule
7(x)(i). 
 (ii) Deposit accounts with banks. 

(iii) Investments in the Company or a Subsidiary. 

(iv) Hedging Agreements entered into in the ordinary course of the Company’s financial planning and not for speculative purposes. 

  
 47 

 (v) Advances to officers, directors and employers of such Person in the ordinary course of
business (provided that such advances have been approved by a majority of the disinterested members of the Board of Directors). 

(vi) Accounts receivable in the ordinary course of business on reasonable and customary trade terms. 

(vii) Other investments in accordance with the Investment Guidelines. 

(y) Subsidiary Indebtedness. The Company shall not permit the aggregate principal amount of Indebtedness (other than the Obligations)
of its Subsidiaries at any time to exceed $1,000,000. 
 (z) Restrictive Agreements. (i) The Company shall not, directly or
indirectly, enter into, incur or permit to exist any agreement or other arrangement that prohibits, restricts or imposes any condition upon (A) the ability of the Company or any Subsidiary to create, incur or permit to exist any Lien upon any
of its property or assets; or (B) the ability of any Subsidiary to pay dividends or other distributions with respect to any shares of its capital stock or to make or repay loans or advances to the Company or any other Subsidiary or to guarantee
Indebtedness of the Company or any other Subsidiary. 
 (ii) (A) The foregoing paragraph, however, shall not apply to (x) restrictions
and conditions imposed by law or by this Note, the other Loan Documents, the Investment Agreement and the other contracts, agreements and other documents entered into in connection therewith; and (y) restrictions and conditions existing on the
date hereof identified on Schedule 7(z)(ii) (but shall apply to any extension or renewal of, or any amendment or modification expanding the scope of, any such restriction or condition); and (B) Clause (A) of paragraph (i) above
shall not apply to (x) restrictions or conditions imposed by any agreement relating to secured Indebtedness permitted by this Note if such restrictions or conditions apply only to the property or assets securing such Indebtedness; and
(y) customary provisions in leases and other contracts restricting the assignment thereof. 
 (aa) Limitation on Layering.
Notwithstanding the provisions of Section 7(p), the Company shall not incur any Indebtedness that is subordinate or junior in right of payment to the Obligations, and senior in any respect in right of payment to any Indebtedness permitted under
clause (iii) of Section 7(p). 
 (bb) Clinical Trials. The Company will take all reasonable and necessary steps to
pursue clinical evaluations related to the approvability or approval of product candidates including making all necessary filings with the FDA or other authority. The Company will not voluntarily cease any such material clinical evaluations without
the Holders’ approval. 
 (cc) SEC Filing Compliance. The Company shall file all required reports, schedules, registration
statements and other documents with the SEC. Each report, registration statement, definitive proxy statement and information statement, including any certifications pursuant to Section 302 or Section 906 of the Sarbanes-Oxley Act of 2002
or similar certifications, filed by the Company or any Subsidiary under the Securities Act or under Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (collectively, the “Company Ongoing SEC Documents”), with the SEC,
(i) shall comply in all material respects as to form with the applicable requirements under the Securities Act or the Exchange Act, as the case may be; and (ii) as of its filing date, shall not contain any untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary to make the statements made therein, in light of the circumstances under which they are made, not misleading; and each of the balance sheets contained in or
incorporated by reference into any such Company Ongoing SEC Document (including the related notes and schedules thereto) shall fairly present the financial position of the entity or entities to which it relates as of its date, and each of the Income
Statements and Cash Flow Statements or equivalent statements in such Company Ongoing SEC Documents (including any related notes and schedules thereto) shall fairly present the results of operations, changes in stockholders’ equity and changes
in cash flows, as the case may be, of the entity or entities to which it relates for the periods to which it relates, in each case in accordance with GAAP consistently applied during the periods involved, except, in each case, as may be noted
therein, subject to normal year-end audit adjustments in the case of unaudited statements. 

  
 48 

 (dd) Non-Domestic Intellectual Property. As soon as practicable after the date that the
Company shall acquire any item of Non-Domestic Intellectual Property, but in no event later than the date twenty Business Days thereafter, the Company shall take all actions necessary or advisable to perfect to the maximum extent permitted or
recognized under applicable law (or attain the functional equivalent of perfection of) the security interest granted to the Holders in Non-Domestic Intellectual Property constituting Collateral, other than specific items of Non-Domestic Intellectual
Property reasonably requested by the Company in writing, including a description thereof in reasonable detail (including without limitation identifying information for such item, a description thereof, its location and an estimated Dollar value
therefor), which the Holders reasonably consent in writing is not subject to perfection (or the functional equivalent of perfection cannot be obtained) of the security interest therein; provided, however, that any failure to so perfect
during such twenty Business Day period, as may be extended pursuant to this Section 7(dd), other than a failure arising from the Company or any agent of the Company failing to take any such necessary or advisable action, shall not during such
period constitute an Event of Default hereunder or under any other Loan Document. Upon the perfection (or the functional equivalent of perfection) of the Holder’s security interest in an items of Non-Domestic Intellectual Property constituting
Collateral, the Company shall as soon as reasonably practicable cause the delivery to the Holders of a legal opinion of its outside counsel with respect to such perfection (or functional equivalent) in form consistent, to the extent applicable, with
other legal opinions delivered by the Company’s counsel under this Note and the other Transaction Documents and reasonably acceptable to the Holder. Upon written request by the Company to the Holder for consent to the non-perfection (or
functional equivalent) of the security interest in any item of Non-Domestic Intellectual Property, complying with this Section 7(dd), the Holder shall endeavor to deliver a determination with respect to such request within two Business Days
after receipt thereof, provided, that in the event the Holder shall not render such determination within two Business Days, the twenty Business Day period during which the Company is otherwise obligated pursuant to this Section 7(dd) to
perfect the security interest in such item shall automatically be extended by the number of Business Days equal to the number of Business Days after such two Business Day period through the date the Holder renders such determination. 

  
 49 

 (ee) Company Milestones. The Company shall furnish to the Holder such information as the
Holder may reasonably request in connection with the status of the Company’s efforts to achieve the Milestones on, or prior to, the applicable milestone deadline set forth on Exhibit E. 

(ff) Information Reporting. Promptly upon the request of the Holders, the Company shall furnish in writing to the Holders such
information as reasonably requested in connection with any calculation to be made in connection with this Note, the Facility, the Royalty Agreement, the Bridge Notes or the Reimbursement Notes, including any calculation regarding the Cash Royalty
Pro Forma Cash Balance, Cash Flow Sweep Pro Forma Cash Balance or any other calculation performed in connection with any mandatory redemption or other payment under any such agreements. 

(gg) Cash and Cash Equivalents. The Company shall not convert any cash or Cash Equivalents held by the Company or any of its
Subsidiaries to other assets for any purposes that include reducing the amounts otherwise payable pursuant to Sections 4(b)(i) or 4(b)(iii) hereof. 

8. Events of Default. 

(a) If one or more of the following events (each an “Event of Default”) occurs and is continuing, the Holder shall be
entitled to exercise any or all of the remedies set forth in Section 8(b). 
 (i) The Company fails to pay any Obligation as and when
that amount becomes due and payable. 
 (ii) The Company fails to perform or observe any covenant or agreement other than those referred to
in Section 8(a)(i) and does not remedy the failure on or before the 10th day after it occurs. 
 (iii) Any representation or warranty
of the Company in this Note or any other Loan Document proves to have been incorrect, incomplete or misleading in any material respect at the time it was made or deemed to have been made; provided, however, that the Company’s
inability to provide the certification described in Section 7(b)(iv)(2) hereof shall not constitute an Event of Default under this Note or the other Loan Documents. 

(iv) Any of the Security Documents shall cease, for any reason, to be in full force and effect; or (ii) the Lien created by any of the
Security Documents shall fail to constitute a Perfected Lien in the Collateral; provided, that (A) solely with respect to any individual item of Collateral having a fair market value of $25,000 (as reasonably determined by the Company in
good faith and reasonably agreed to by the Holder) or less, such failure to maintain a Perfected Lien in such item of Collateral shall not constitute an Event of Default unless the Company does not remedy such failure on or before the 5th day after
such failure occurs, (B) such failure to maintain a Perfected Lien in such item of Collateral shall not constitute an Event of Default if such failure results solely from any action or failure to act on the part of the Holder (following notice
thereof from the Company) to maintain such Perfected Lien and which action or failure to act contravenes the provisions of this Note, the other Loan Documents or applicable law, and (C) notwithstanding anything herein or in any Loan Document to
the contrary, the failure to perfect (or attain the functional equivalent of perfection of) the security interest granted to the Holder in any Non-Domestic Intellectual Property constituting Collateral prior to the date required therefor pursuant to
Section 7(dd), shall not constitute an Event of Default. 

  
 50 

 (v) Any Event of Default (as such term is defined in the Facility, the Bridge Note or the
Reimbursement Note, as applicable) shall occur under the Facility, the Bridge Note or the Reimbursement Note; or the Company or any Subsidiary: (A) fails to pay any of its other Indebtedness as and when that Indebtedness becomes due and
payable; or (B) fails to perform or observe any covenant or agreement to be performed or observed by it contained in any other agreement or in any instrument evidencing any of its other Indebtedness (and any cure period under such other
agreement or instrument shall have expired) and, as a result of the failure, any other party to that agreement or instrument is entitled to exercise the right to accelerate the maturity of any amount owing thereunder. 

(vi) (A) A court enters a decree or order for relief with respect to the Company in an involuntary case under the Bankruptcy Code, which
decree or order is not stayed or other similar relief is not granted under any applicable federal or state law; or (B) the continuance of any of the following events for 45 days unless dismissed, bonded or discharged: (x) an involuntary
case is commenced against the Company, under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect; or (y) a decree or order of a court for the appointment of a receiver, liquidator, sequestrator, trustee,
custodian or other officer having similar powers over the Company, or over all or a substantial part of its property, is entered; or (z) a receiver, trustee or other custodian is appointed without the consent of the Company, for all or a
substantial part of the property of the Company. 
 (vii) (A) The Company commences a voluntary case under the Bankruptcy Code, or
consents to the entry of an order for relief in an involuntary case or to the conversion of an involuntary case to a voluntary case under any such law or consents to the appointment of or taking possession by a receiver, trustee or other custodian
for all or a substantial part of its property; or (B) the Company makes any assignment for the benefit of creditors; or (C) the Board of Directors adopts any resolution or otherwise authorizes action to approve any of the actions referred
to in this Section 8(a)(vii). 
 (viii) Any authorization from any Governmental Authority necessary for the performance of any
obligation of the Company under this Note or the Loan Documents, or the consummation of the Proposed Transactions, is not or fails to remain valid and subsisting in full force and effect. 

(ix) Any Governmental Authority takes any action that, in the determination of the Holders could have a Material Adverse Effect on the
Company. 
 (x) One or more judgments for the payment of money in an aggregate amount in excess of $100,000 shall be rendered against the
Company and the same shall remain undischarged for a period of 30 consecutive days during which execution shall not be effectively stayed, or any action shall be legally taken by a judgment creditor to attach or levy upon any assets of the Company
to enforce any such judgment. 

  
 51 

 (xi) The Company sells or otherwise disposes of all or a substantial part of its assets or ceases
to conduct all or a substantial part of its business as now conducted, or merges or consolidates with any other Person without the prior written consent of the Holder. 

(xii) The Common Stock is suspended from trading on any of, or is not listed (and authorized) for trading on at least one of, The Nasdaq Stock
Market, The Nasdaq SmallCap Market, The New York Stock Exchange, The American Stock Exchange and is not eligible for trading on the OTCBB for an aggregate of 10 Trading Days in any 9 month-period. 

(xiii) The Company fails to achieve any of the Milestones set forth on Exhibit E on or prior to the applicable milestone deadline set
forth thereon. 
 (xiv) The Company fails to pay any Royalty when due pursuant to, or breaches any of its obligations under, the terms of
the Royalty Agreement. 
 (b) If any Event of Default occurs and is continuing, the Holder may, by notice to the Company, (i) declare
the obligations of the Holder hereunder to be terminated forthwith, whereupon those obligations shall immediately terminate; and/or (ii) declare all amounts payable hereunder or under the Loan Documents by the Company that would otherwise be
due after the date of termination to be immediately due and payable, whereupon all those amounts shall become immediately due and payable, all without diligence, presentment, demand of payment, protest or notice of any kind, which are expressly
waived by the Company; provided, however, that if any event of a kind referred to in Section 8(a)(vi) or Section 8(a)(vii) occurs, the obligations of the Holder hereunder shall immediately terminate, and all
amounts payable hereunder by the Company that would otherwise be due after the occurrence of that event shall become immediately due and payable without any such notice or other formality waived by the Company in this Section. 

(c) Right of Setoff. If any amount payable hereunder is not paid as and when due, the Company authorizes the Holder and each Affiliate
of the Holder to proceed, to the fullest extent permitted by applicable law, without prior notice, by right of setoff, banker’s Lien, counterclaim or otherwise, against any assets of the Company in any currency that may at any time be in the
possession of the Holder or that Affiliate, at any branch or office, to the full extent of all amounts due and payable to the Holder hereunder. 

(d) Rights Not Exclusive. The rights provided for herein are cumulative and are not exclusive of any other rights, powers, privileges
or remedies provided by law. 
 9. Governing Law. This Note shall, pursuant to Sections 5-1401 and 5-1402 of the General Obligations
Law of the State of New York, be construed and interpreted in accordance with the law of the State of New York. 
 10.
Jurisdiction. (a) The Company irrevocably submits to the jurisdiction of the courts of the State of New York and of the United States sitting in the Borough of Manhattan in respect of any action or Proceeding relating in any way to
this Note or any Note (a “Proceeding”). The Company irrevocably appoints CT Corporation System, which currently maintains a New York City office situated at 111 Eighth Ave., 13th Floor, New York, New York 10011, as
its agent to receive service of process or other legal summons for purposes of any Proceeding. So long as the Company has any obligation under this Note, it will maintain a duly appointed agent in New York City acceptable to the Holder for the
service of such process or summons and, if it fails to maintain such an agent, any such process or summons may be served on it by mailing a copy thereof by registered mail, or a form of mail substantially equivalent thereto, addressed to the Company
at its address for notices hereunder. 

  
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 (b) The Company irrevocably waives, to the fullest extent permitted by applicable law, any
objection that it may now or hereafter have to the laying of venue of any Proceeding in the Supreme Court of the State of New York, County of New York, or the United States District Court for the Southern District of New York and any
claim that any Proceeding brought in any such court has been brought in an inconvenient forum. 
 (c) The Company further irrevocably
waives, to the fullest extent permitted by applicable law, any claim that any Proceeding should be dismissed or stayed by reason, or pending the resolution, of any action or proceeding commenced by the Company relating in any way to this Note or any
other Loan Document, whether or not commenced earlier. To the fullest extent permitted by applicable law, the Company shall take all measures necessary for the Proceeding to proceed to judgment prior to the entry of judgment in any such action or
proceeding commenced by the Company. 
 11. Notices. All notices and other communications given to any party hereto pursuant to this
Note shall be in writing and shall be delivered by hand, fax or email (and in the case of fax or email, receipt confirmed immediately via telephone), or mailed first class postage prepaid, registered or certified mail, addressed as follows: 

If to the Company, to: 

Emisphere Technologies, Inc. 
 4
Becker Farm Road, Suite 103 
 Roseland, NJ 07068 

Attention: Chief Financial Officer 

Phone: (973) 532-8000 
 Fax:
(973) 422-0125 
 Email: mgarone@emisphere.com 

with a copy to: 
 Lowenstein
Sandler LLP 
 65 Livingston Avenue 

Roseland, NJ 07068 
 Attention:
Michael H. Lerner, Esq. 
 Phone: (973) 575-2500 

Fax: (973) 575-2400 
 Email:
mlerner@lowenstein.com 
  

  
 53 

 If to the Holder, to: 

c/o MHR Fund Management LLC 
 40
West 57th Street, 24th Floor 
 New York, NY 10019 

Fax number: (212) 262-9356 

Attention: Janet Yeung 
 Phone:
(212) 262-0005 
 Fax: (212) 262-9356 

Email: jyeung@mhrfund.com 
 with
a copy to: 
 O’Melveny & Myers LLP 

7 Times Square 
 New York, NY
10036 
 Attn: David Schultz, Esq. 

Phone: (212) 326-2000 
 Fax:
(212) 326-2061 
 Email: dschultz@omm.com 

Each such notice or other communication shall for all purposes be treated as being effective or having been given when delivered, if delivered personally, by
e-mail or facsimile with confirmation of receipt or if by overnight courier or, if sent by mail, upon actual receipt. 
 12. Waivers.
No failure or delay on the part of the Holder in exercising any right hereunder shall operate as a waiver of, or impair, any such right. No single or partial exercise of any such right shall preclude any other or further exercise thereof or the
exercise of any other right. No waiver of any such right or of any obligation of the Company shall be effective unless given in writing and executed by the Holder. No waiver of any such right shall be deemed a waiver of any other right hereunder.

 13. Amendment. This Note may be amended only by an instrument in writing executed by the Company and the Holders. 

14. Replacement of Note. Upon the loss, theft, destruction or mutilation of this Note, and upon the execution and delivery by the
Holder to the Company of an affidavit in form and substance reasonably acceptable to the Company attesting to such loss, theft, destruction or mutilation, as the case may be, and an agreement, in form and substance reasonably acceptable to the
Company indemnifying and holding the Company harmless from and against any liability or damages arising therefrom, the Company shall execute and deliver in lieu thereof a new Note, dated the date of the Note being replaced, in the same principal
amount. 
 15. Further Assurances. The Company shall do and perform, or cause to be done and performed, all such further acts and
things, and shall execute and deliver all such other agreements, certificates, instruments and documents (including without limitation any intercreditor agreements and subordination agreements), as the Holder may reasonably request in order to carry
out the intent and accomplish the purposes of this Note and the consummation of the transactions contemplated hereby. 

  
 54 

 16. Survival. The obligations of the Company under Sections 9 through 13 and 17 through 19
shall survive the full repayment and the cancellation of this Note and the termination of the other obligations of the Company hereunder. 

17. Successors and Assigns. This Note shall inure to the benefit of, be binding upon and be enforceable by and against the parties
hereto and their respective successors and permitted assigns. 
 18. Headings. The headings of the sections of this Note are inserted
for convenience only and do not constitute a part of this Note. 
 19. Nature of Obligations. The Obligations under this Note, all
other 13% Senior Secured Convertible Notes issued by the Company in a form substantially similar to this Note and the other Loan Documents referred to herein and therein are executed and delivered in substitution for, but not in satisfaction of, the
obligations under the Existing Notes and the Loan Documents referred to therein (collectively, the “Precedent Obligations”) and this Note shall not constitute a refinancing, substitution or novation of the Precedent Obligations.

 [The Remainder of This Page is Intentionally Left Blank] 

  
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 IN WITNESS WHEREOF, the Company has caused this Note to be signed and to be dated the day and
year first above written. 
  

			
	EMISPHERE TECHNOLOGIES, INC.
		
	By:	 	 
	Name:	 	
	Title:	 	

 Agreed and Assented to by Holder: 

[MHR FUNDS] 
  

			
		
	By:	 	 
	Name:	 	
	Title:	 	

  

 EXHIBIT A 

Notice of Conversion 

  

 EXHIBIT B 

Pledge and Security Agreement 

  

 EXHIBIT C 

Form of Compliance Certificate 

  

 EXHIBIT D 

Investment Guidelines 

  

 EXHIBIT E 

Milestone Schedule 
 (A) Net Product
Sales Milestones: 
 1. The Company shall have Net Sales during the Fiscal Year ended December 31, 2015 of at least $4.3 million. 

2. The Company shall have Net Sales during the Fiscal Year ended December 31, 2016 of at least $23.0 million. 

3. The Company shall have Net Sales during the Fiscal Year ended December 31, 2017 of at least $45.7 million. 

4. The Company shall have Net Sales during the Fiscal Year ended December 31, 2018 of at least $73.5 million. 

5. The Company shall have Net Sales during the Fiscal Year ended December 31, 2019 of at least $75.3 million. 

(B) Eligen-B12 Manufacturing Milestones: 
 1. The Company
shall have procured at least (a) 10 kg of Vitamin B12 and (b) 700 kg of SNAC on or prior to December 31, 2014. 
 2. The Company shall have procured at
least an additional (a) 20 kg of Vitamin B12 (for a total of 30 kg of Vitamin B12) and (b) 600 kg of SNAC (for a total of 1,300 kg of SNAC) on or prior to March 31, 2015. 

3. The Company shall have at least 6 million tablets of Eligen-B12 manufactured and available for commercial sale on or prior to June 30, 2015. 

4. The first commercial sale of Eligen-B12 in the United States shall have taken place on or prior to September 30, 2015. 

 
  

“Net Sales” means, for any period, Revenues, plus any gross sales by any non-consolidated Affiliate or sub-licensee, distributor or partner during
such period, in each case with respect to all sales, transfers or other dispositions of Designated Products (whether to end-users, distributors or otherwise), less the following deductions, to the extent reasonable and customary, not already
deducted from Revenues or gross sales, as applicable, and incurred with respect to the applicable sale, transfer or other disposition of the Designated Product: (i) import, export, excise and sales taxes (including duties or other governmental
charges levied on, absorbed or otherwise imposed on the sale of Designated Product including, without limitation, value added taxes or other governmental charges otherwise measured by the billing amount, when included in billing), (ii) custom
duties, (iii) credits or allowances granted on returns of Designated Products actually sold, (iv) bad debt deductions actually written off during such period, and (v) trade, cash and quantity discounts, allowances and credits. The Company shall
provide written notice to the Holders of the amount of Net Sales for any applicable Fiscal Year no later than thirty (30) days following the end of such Fiscal Year. 

“Revenues” means the amount ascribed to “Revenues” in the Income Statement. 

  

 EXHIBIT F 

Company’s Operating Budget 

  

 EXHIBIT G 

SchedulesEX-4.3

 Exhibit 4.3 

FORM OF SECOND AMENDED & RESTATED REIMBURSEMENT PROMISSORY NOTE 

 

			
	$[                    ]	  	August 20, 2014

 1. FOR VALUE RECEIVED, the undersigned, Emisphere Technologies, Inc., a Delaware corporation (“Maker”),
unconditionally promises to pay to the order of [                    ], a limited partnership organized in
[                    ] (“Creditor”), the principal sum of
[                                ] DOLLARS
($[                    ]), with the entire principal balance due and payable on the Maturity Date (as defined below). The Maturity Date is
subject to adjustment as set forth below. The obligations under this Note are secured by a security interest in substantially all the assets of the Maker pursuant to the Amended and Restated Pledge and Security Agreement, dated as of the date hereof
(the “Security Agreement”) by and between Maker and MHR Institutional Partners IIA LP, as secured party. This promissory note (the “Note”) amends and restates in its entirety that certain Amended and Restated
Promissory Note dated as of May 7, 2013, by Maker in favor of Creditor (the “Existing Note”). 
 2. Interest. Except as
otherwise provided herein, the unpaid principal balance of this Note outstanding from time to time shall bear interest at a rate of ten percent (10%) per annum, compounded monthly, and will be payable in arrears semi-annually on each
June 30th and December 31st in kind through issuance to the Creditor of additional Notes (in a form substantially similar to the form of this Note with appropriate notations for the date of issuance and initial principal amount). After the
Maturity Date (whether by acceleration after an Event of Default or otherwise), interest shall be payable on the unpaid principal balance from time to time outstanding at a rate equal to twelve percent (12%) per annum, compounded monthly, and
will be payable in arrears semi-annually on each June 30th and December 31st in kind through issuance to the Creditor of additional Notes (in a form substantially similar to the form of this Note with appropriate notations for the date of
issuance and initial principal amount). Interest, if any, shall be calculated on the basis of a 360-day year times the actual number of days elapsed, until paid in full. 

3. Optional Redemption. 
 (a) The Maker
may redeem this Note, in whole or in part, at any time, at a redemption price (the “Optional Redemption Price”) equal to the principal amount of this Note, plus accrued and unpaid interest thereon, if any, through the date of such
redemption, if at the time of any such redemption all of the Common Stock into which this Note (or a portion thereof subject to such redemption) is convertible is freely transferable by the Creditor without any restriction pursuant to registration
or exemption under all applicable United States federal and state securities laws (such redemption, an “Optional Redemption”). Notwithstanding anything to the contrary in this Section 3(a), until the Optional Redemption
Price is paid, in full, the Creditor may convert all or any part of the outstanding principal amount of this Note, plus accrued interest thereon, if any, through the Conversion Date, into a number of Conversion Shares in accordance with
Section 4 hereof. 
 (b) The Maker shall give written notice in respect of an Optional Redemption to each Creditor pursuant to
Section 17 at least twenty (20) but not more than thirty (30) days before the date of such Optional Redemption (the “Optional Redemption Date”). In the case of any Optional Redemption of the Notes in part, the
balance of the Notes to be redeemed pursuant to Section 3(a) shall be allocated among all of the Reimbursement Notes at the time outstanding in proportion, as nearly as practicable, to the respective unpaid principal balances thereof.
The Maker shall apply any amounts to be used for Optional Redemption pursuant to this Section 3(a), first, to pay accrued and unpaid interest on the Notes, if any, then to redeem the principal amount of the Notes or any portion thereof.
Each notice in respect of an Optional Redemption given pursuant to this Section 3(b) shall state (A) the Optional Redemption Date, (B) the projected Optional Redemption Price of the Notes to be redeemed, (C) in the case of
an Optional Redemption of the Notes in part, the portion of the outstanding balance of the Notes that is expected to be redeemed and the aggregate balance of Notes to be outstanding after such partial Optional Redemption, (D) that Notes to be
redeemed in an Optional Redemption in whole must be surrendered (which action may be taken by any Creditor or its authorized agent) to the Maker to collect the Optional Redemption Price on such Notes, and specifying the procedures for such surrender
and (E) that, unless the Maker fails to pay the Optional Redemption Price, interest, if any, on Notes, (or the portion thereof) called for Optional Redemption shall cease to accrue after the Optional Redemption Date. 

  

 (c) If notice in respect of an Optional Redemption for any Notes shall have been given as
provided in Section 3(b), such Notes shall become due and payable on the Optional Redemption Date at the applicable Optional Redemption Price, and, unless there is a default in the payment of the applicable Optional Redemption Price, interest
on such Notes, if any, shall cease to accrue on and after such Optional Redemption Date. Upon presentation and surrender of such Notes to the Maker in accordance with the notice given pursuant to Section 3(b), such Notes shall be paid and
redeemed at the applicable Optional Redemption Price on the Optional Redemption Date. 
 (d) Upon surrender of a Note that is redeemed in
part pursuant to Section 3(a) the Maker shall execute for the Creditor (at the Maker’s expense) a new Note (in a form substantially similar to the form of this Note with appropriate notations for the date of issuance and initial
principal amount) equal in principal balance to the unredeemed portion of the Note surrendered. 
 (e) All Notes that are redeemed pursuant
to Section 3 will be surrendered to the Maker for cancellation and may not be reissued or resold. 
 4. Mandatory Prepayment. 

(a) Thirty (30) days following the Maker’s or any of its Subsidiaries’ receipt of any cash or Cash Equivalents (i) from
any third party in connection with the license, distribution or sale of any of the Maker’s or any of its Subsidiaries’ products (including if such products are combined or are proposed to be combined with proprietary technology or products
of any other Person), including without limitation, lump-sum payments such as milestone payments, upfront payments or payments made in consideration of reduction of royalty rates (but excluding any such lump-sum payments from any third party in
connection with the license, distribution or sale of the Designated Products and the direct sale by the Maker or any of its Subsidiaries of its products (including the Designated Products) to customers or royalty payments based solely on the
percentage of product sales or comparable metrics, in each case in the ordinary course of business of the Maker or its Subsidiaries), or (ii) outside of the ordinary course of business, but only to the extent unrelated to the sale, license or
distribution of the Designated Products (any such cash or Cash Equivalents described in clauses (i) and/or (ii) of this Section 4(a), the “Cash Proceeds”), the Maker shall use 50% of any such Cash Proceeds to redeem
the Reimbursement Note in accordance with this Section 4 (each such redemption, a “Mandatory Redemption”). Notwithstanding anything to the contrary in this Section 4(a), until the Note (or portion thereof) is redeemed
pursuant to this Section 4(a) (the date on which any such redemption occurs, a “Mandatory Redemption Date”), the Creditor may convert all or any part of the outstanding principal amount of this Note to be redeemed, plus accrued
interest thereon, through the Conversion Date, into a number of Conversion Shares in accordance with Section 5 hereof. 
 (b) The Maker
shall give written notice in respect of a Mandatory Redemption to each Creditor pursuant to Section 17 at least twenty (20) days before the Mandatory Redemption Date. In the case of any Mandatory Redemption of this Note in part, the
portion of the Note to be redeemed pursuant to Section 4(a) shall be allocated among all of the Reimbursement Notes at the time outstanding in proportion, as nearly as practicable, to the respective unpaid principal balances thereof. The Maker
shall apply any amounts to be used for Mandatory Redemption pursuant to this Section 4(a), first, to pay accrued and unpaid interest on the Reimbursement Notes, then to redeem the principal amount of the Reimbursement Notes or any portion
thereof. Each notice in respect of a Mandatory Redemption given pursuant to this Section 4(b) shall state (A) the Mandatory Redemption Date, (B) in the case of a Mandatory Redemption of the Notes in part, the portion of the
outstanding balance of the Reimbursement Notes that is expected to be redeemed and the aggregate balance of Reimbursement Notes to be outstanding after such partial Mandatory Redemption, (C) that Reimbursement Notes to be redeemed in a
Mandatory Redemption in whole must be surrendered (which action may be taken by any Creditor or its authorized agent) to the Maker to collect the redemption price on such Notes, and specifying the procedures for such surrender and (D) that,
unless the Maker fails to pay to redeem such Notes, interest, on Notes (or the portion thereof) called for Mandatory Redemption shall cease to accrue after the Mandatory Redemption Date. 

  
 2 

 (c) If notice in respect of a Mandatory Redemption for any Reimbursement Notes shall have been
given as provided in Section 4(b), such Notes shall become due and payable on the Mandatory Redemption Date, and, unless there is a default in the payment of such Mandatory Redemption, interest on such Notes shall cease to accrue on and after
such Mandatory Redemption Date. Upon presentation and surrender of such Notes to the Maker in accordance with the notice given pursuant to Section 4(b), such Notes shall be paid and redeemed on the Mandatory Redemption Date. 

(d) Upon surrender of a Note that is redeemed in part pursuant to Section 4(a) the Maker shall execute for the Creditor (at the
Maker’s expense) a new Note (in a form substantially similar to the form of this Note with appropriate notations for the date of issuance and initial principal amount) equal in principal balance to the unredeemed portion of the Note
surrendered. 
 (e) All Notes that are redeemed pursuant to Section 4 will be surrendered to the Maker for cancellation and may not be
reissued or resold. 
 5. Conversion. 

(a) Conversion at the Option of the Creditor. The Creditor may, at any time and from time to time on or after the date hereof, convert
all or any part of the outstanding principal amount of this Note, plus all accrued interest thereon, if any, through the Conversion Date, into a number of fully paid and nonassessable shares of Common Stock (“Conversion Shares”)
upon surrender of this Note. The number of shares of Common Stock issuable upon surrender of this Note shall be determined in accordance with the following formula: 

Conversion Amount 

Conversion Price 
 (b)
Mechanics of Conversion. In order to effect a conversion pursuant to this Section 5, the Creditor shall: (a) fax (or otherwise deliver) a copy of the fully executed Notice of Conversion, attached hereto as Exhibit A
(the “Notice of Conversion”), to the Maker and (b) surrender or cause to be surrendered this Note, duly endorsed, along with a copy of the Notice of Conversion as soon as practicable thereafter to the Maker. Upon receipt by the
Maker of a facsimile copy of a Notice of Conversion from a Creditor, the Maker shall within two (2) Business Days send, via facsimile, a confirmation to such Creditor stating that the Notice of Conversion has been received, advising the
Creditor of any additional documentation reasonably required by the transfer agent for the Common Stock to issue the Conversion Shares in the manner provided in the Notice of Conversion (the “Additional Documentation”) and the name
and telephone number of a contact person at the Maker regarding the conversion. The Maker shall not be obligated to issue Conversion Shares upon a conversion unless either this Note is delivered to the Maker as provided above, or the Creditor
notifies the Maker that such certificates have been lost, stolen or destroyed and delivers the documentation to the Maker required by Section 15. 

  
 3 

 (c) Delivery of Conversion Shares Upon Conversion. Upon the surrender of this Note
accompanied by a Notice of Conversion and any Additional Documentation, the Maker shall, no later than the later of (a) the second Business Day following the Conversion Date and (b) the third Business Day following the date of such
surrender (or, in the case of lost, stolen or destroyed certificates, after provision of indemnity pursuant to Section 15) (the “Delivery Period”), issue and deliver to the Creditor or its nominee (x) that number of
Conversion Shares issuable upon conversion of the portion of this Note being converted and (y) a new Note in the form hereof representing the balance of the principal amount hereof not being converted, if any. If the Maker’s transfer agent
is participating in the Depositary Trust Company (“DTC”) Fast Automated Securities Transfer program, and so long as the certificates therefor do not bear a legend and the Creditor thereof is not then required to return such
certificate for the placement of a legend thereon, the Maker shall cause its transfer agent to electronically transmit the Conversion Shares to the Creditor by crediting the account of the Creditor or its nominee with DTC, as specified in the Notice
of Conversion, through its DTC Deposit Withdrawal Agent Commission System (“DTC Transfer”). If the aforementioned conditions to a DTC Transfer are not satisfied, the Maker shall deliver to the Creditor physical certificates
representing the Conversion Shares. Further, the Creditor may instruct the Maker to deliver to the Creditor physical certificates representing the Conversion Shares in lieu of delivering such shares by way of DTC Transfer. 

(d) Adjustment to Conversion Price. The Conversion Price in effect at any time shall be subject to adjustment from time to time upon
the happening of certain events, as follows: 
 (i) Common Stock Dividends; Common Stock Splits; Reverse Common Stock Splits. If the
Maker, at any time while this Note is outstanding, (A) shall pay a stock dividend on its Common Stock, (B) subdivide outstanding shares of Common Stock into a larger number of shares, or (C) combine outstanding shares of Common Stock
into a smaller number of shares, the Conversion Price shall be multiplied by a fraction the numerator of which shall be the number of shares of Common Stock (excluding treasury shares, if any) outstanding before such event and the denominator of
which shall be the number of shares of Common Stock outstanding after such event. Any adjustment made pursuant to this Section 5(d)(i) shall become effective immediately after the record date for the determination of stockholders
entitled to receive such dividend or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification. 

(ii) Subscription Rights. If the Maker, at any time while this Note is outstanding, shall fix a record date for the distribution to all
of the holders of Common Stock evidence of its indebtedness or assets or rights, options, warrants or other securities entitling them to subscribe for, purchase, convert to, exchange for or to otherwise acquire any security (excluding those referred
to in Section 5(d)(i) above), then in each such case the Conversion Price at which this Note shall thereafter be exercisable shall be determined by multiplying the Conversion Price in effect immediately prior to the record date fixed for
determination of stockholders entitled to receive such distribution by a fraction, the denominator of which shall be the average Daily Market Price of the Common Stock for the ten (10) Trading Days prior to the record date mentioned above, and
the numerator of which shall be such average Daily Market Price of the Common Stock for the ten (10) Trading Days prior to such record date less the then fair market value at such record date of the portion of such evidence of indebtedness or
assets or rights, options, warrants or other securities so distributed applicable to one outstanding share of Common Stock as determined by the Board of Directors in good faith; provided, however, that in the event of a distribution exceeding twenty
percent (20%) of the net assets of the Maker, such fair market value shall be determined by an appraiser selected by the Creditor and reasonably acceptable to the Maker. The Maker shall pay for all such appraisals. Such adjustment shall be made
whenever any such distribution is made and shall become effective immediately after the record date mentioned above. 

  
 4 

 (iii) Other Events. In case of (A) any reclassification of the Common Stock into
other securities of the Maker, (B) any compulsory share exchange pursuant to which the Common Stock is converted into other securities, cash or property or (C) any merger or consolidation with or into any persons, or any sale or other
disposition of all or substantially all of the assets of the Maker to any person (each of (A), (B) or (C), an “Extraordinary Event”), the Creditor shall have the right thereafter to convert this Note into shares of stock and
other securities, cash and property receivable upon or deemed to be held by holders of Common Stock following such Extraordinary Event, that the Creditor would have been entitled to receive had it converted this Note immediately prior to such
Extraordinary Event (without taking into account any limitations or restrictions on the convertibility of this Note). In the case of an Extraordinary Event, the terms of any such Extraordinary Event shall include such terms so as to continue to give
to the Creditor the right to receive the securities, cash or property set forth in this Section 5(d)(iii) upon any conversion following such Extraordinary Event. This provision shall similarly apply to successive Extraordinary Events.

 (iv) Issuance of Additional Shares of Common Stock. Except as provided in subsection (v) hereof, if and whenever the Maker
shall issue or sell, or is, in accordance with any of subsections (iv)(A) through (iv)(H) hereof, deemed to have issued or sold, any Additional Shares of Common Stock (defined below) for a consideration per share less than the Conversion Price in
effect immediately prior to the time of such issue or sale, then and in each such case (a “Trigger Issuance”) the then-existing Conversion Price shall be reduced, as of the close of business on the effective date of the Trigger
Issuance, to the lowest price per share at which any share of Common Stock was issued or sold or deemed to be issued or sold in the Trigger Issuance. For purposes of this subsection (iv), “Additional Shares of Common Stock” means
all shares of Common Stock issued by the Maker or deemed to be issued pursuant to this subsection (iv), other than Excluded Issuances (as defined in subsection (v) hereof). 

For purposes of this subsection (iv), the following subsections (iv)(A) to (iv)(H) shall also be applicable (subject, in each such case, to
the provisions of subsection (v) hereof) and to each other subsection contained in this subsection (iv): 
 (A) Issuance of Rights
or Options. In case at any time the Maker shall in any manner grant (directly and not by assumption in a merger or otherwise) any warrants or other rights to subscribe for or to purchase, or any options for the purchase of, Common Stock or any
stock or security convertible into or exchangeable for Common Stock (such warrants, rights or options being called “Options” and such convertible or exchangeable stock or securities being called “Convertible
Securities”) whether or not such Options or the right to convert or exchange any such Convertible Securities are immediately exercisable, and the price per share for which Common Stock is issuable upon the exercise of such Options or upon
the conversion or exchange of such Convertible Securities (determined by dividing (i) the sum (which sum shall constitute the applicable consideration) of (x) the total amount, if any, received or receivable by the Maker as consideration
for the granting of such Options, plus (y) the aggregate amount of additional consideration payable to the Maker upon the exercise of all such Options, plus (z), in the case of such Options which relate to Convertible Securities, the aggregate
amount of additional consideration, if any, payable upon the issue or sale of such Convertible Securities and upon the conversion or exchange thereof, by (ii) the total maximum number of shares of Common Stock issuable upon the exercise of such
Options or upon the conversion or exchange of all such Convertible Securities issuable upon the exercise of such Options) shall be less than the Conversion Price in effect immediately prior to the time of the granting of such Options, then the total
number of shares of Common Stock issuable upon the exercise of such Options or upon conversion or exchange of the total amount of such Convertible Securities issuable upon the exercise of such Options shall be deemed to have been issued for such
price per share as of the date of granting of such Options and thereafter shall be deemed to be outstanding for purposes of adjusting the Conversion Price. Except as otherwise provided in subsection (iv)(D), no adjustment of the Conversion Price
shall be made upon the actual issue of such Common Stock or of such Convertible Securities upon exercise of such Options or upon the actual issue of such Common Stock upon conversion or exchange of such Convertible Securities. 

  
 5 

 (B) Issuance of Convertible Securities. In case the Maker shall in any manner issue
(directly and not by assumption in a merger or otherwise) or sell any Convertible Securities, whether or not the rights to exchange or convert any such Convertible Securities are immediately exercisable, and the price per share for which Common
Stock is issuable upon such conversion or exchange (determined by dividing (i) the sum (which sum shall constitute the applicable consideration) of (x) the total amount received or receivable by the Maker as consideration for the issue or
sale of such Convertible Securities, plus (y) the aggregate amount of additional consideration, if any, payable to the Maker upon the conversion or exchange thereof, by (ii) the total number of shares of Common Stock issuable upon the
conversion or exchange of all such Convertible Securities) shall be less than the Conversion Price in effect immediately prior to the time of such issue or sale, then the total maximum number of shares of Common Stock issuable upon conversion or
exchange of all such Convertible Securities shall be deemed to have been issued for such price per share as of the date of the issue or sale of such Convertible Securities and thereafter shall be deemed to be outstanding for purposes of adjusting
the Conversion Price, provided that (a) except as otherwise provided in subsection (iv)(D), no adjustment of the Conversion Price shall be made upon the actual issuance of such Common Stock upon conversion or exchange of such Convertible
Securities and (b) no further adjustment of the Conversion Price shall be made by reason of the issue or sale of Convertible Securities upon exercise of any Options to purchase any such Convertible Securities for which adjustments of the
Conversion Price have been made pursuant to the other provisions of subsection (iv). 
 (C) Change in Warrant Price or Amount.
Notwithstanding the provisions of subsection (iii), if the exercise price provided for in any warrants of the Maker on the date hereof is below the Conversion Price and (i) such exercise price is reduced, the then-existing Conversion Price
shall be reduced, as of the close of business on the effective date of such reduction in exercise price by an amount equal to the product of (x) the original exercise price minus (y) the reduced exercise price and (2) a fraction, the
numerator of which is the number of shares of Common Stock that may be acquired upon exercise, if any, of the warrants whose exercise price is reduced and the denominator of which is the aggregate number of shares of Common Stock that may be
acquired upon exercise of all of the outstanding warrants or (ii) the Maker amends the terms of such warrants to increase the number of shares of Common Stock that may be acquired upon exercise of the warrants, the then-existing Conversion
Price shall be reduced, as of the close of business on the effective date of amendment by an amount equal to the product of (1) (x) the original exercise price minus (y) the product of the original exercise price and a fraction, the
numerator of which is the old number of shares for which the warrants were exercisable immediately prior to such amendment and the denominator of which is the new number of shares for which the warrants are exercisable immediately following such
amendment and (2) a fraction, the numerator of which is the number of shares of Common Stock that may be acquired upon exercise, if any, of the warrants whose exercise price is reduced and the denominator of which is the aggregate number of
shares of Common Stock that may be acquired upon exercise of all of the outstanding warrants. 

  
 6 

 (D) Change in Option Price or Conversion Rate. Upon the happening of any of the following
events, namely, if the purchase price provided for in any Option referred to in subsection (iv)(A) hereof, the additional consideration, if any, payable upon the conversion or exchange of any Convertible Securities referred to in subsections (iv)(A)
or (iv)(B), or the rate at which Convertible Securities referred to in subsections (iv)(A) or (iv)(B) are convertible into or exchangeable for Common Stock shall change at any time (including, but not limited to, changes under or by reason of
provisions designed to protect against dilution), the Conversion Price in effect at the time of such event shall forthwith be readjusted to the Conversion Price which would have been in effect at such time had such Options or Convertible Securities
still outstanding provided for such changed purchase price, additional consideration or conversion rate, as the case may be, at the time initially granted, issued or sold. 

(E) Calculation of Consideration Received. If any Common Stock, Options or Convertible Securities are issued, granted or sold for cash,
the consideration received therefor will be the amount received by the Maker therefor, after deduction of all underwriting discounts or allowances in connection with such issuance, grant or sale. In case any Common Stock, Options or Convertible
Securities are issued or sold for a consideration part or all of which shall be other than cash, including in the case of a strategic or similar arrangement in which the other entity will provide services to the Maker, purchase services from the
Maker or otherwise provide intangible consideration to the Maker, the amount of the consideration other than cash received by the Maker (including the net present value of the consideration expected by the Maker for the provided or purchased
services) will be the fair market value of such consideration, except where such consideration consists of securities, in which case the amount of consideration received by the Maker will be the average Daily Market Price for the ten
(10) Trading Days with respect to such securities thereof prior to the date of receipt. In case any Common Stock, Options or Convertible Securities are issued in connection with any merger or consolidation in which the Maker is the surviving
Maker, the amount of consideration therefor will be deemed to be the fair market value of such portion of the net assets and business of the non-surviving Maker as is attributable to such Common Stock, Options or Convertible Securities, as the case
may be. Notwithstanding anything to the contrary contained herein, if Common Stock, Options or Convertible Securities are issued, granted or sold in conjunction with each other as part of a single transaction or in a series of related transactions,
and one or more of such securities are issued, granted or sold for a price below fair market value (when the aggregate value of such securities is compared with the aggregate amount of consideration received by the Maker therefor), the Creditor may
elect to determine the amount of consideration deemed to be received by the Maker therefor by deducting the difference between the fair value of and the amount paid for any type of securities issued, granted or sold in such transaction or series of
transactions (the “Disregarded Securities”). If the Creditor makes an election pursuant to the immediately preceding sentence, no adjustment to the Conversion Price shall be made pursuant to this subsection (iv)(E) for the issuance
of the Disregarded Securities or upon any conversion or exercise thereof. For example, if the Maker were to issue convertible notes having a face value of $1,000,000 and warrants to purchase shares of Common Stock at an exercise price equal to the
market price of the Common Stock on the date of issuance of such warrants in exchange for $1,000,000 of consideration, the fair value of the warrants would be subtracted from the $1,000,000 of consideration received by the Maker for the purposes of
determining the price per share of Common Stock issuable upon conversion of the convertible notes and for purposes of determining any adjustment to the Conversion Price hereunder as a result of the issuance of the Convertible Securities. The
Creditor shall calculate, using standard commercial valuation methods appropriate for valuing such assets, the fair market value of any consideration other than cash or securities; provided, however, that if the Maker does not agree to such fair
market value calculation within three (3) Business Days after receipt of such calculation along with reasonably detailed supporting documentation from the Creditor, then such fair market value will be determined in good faith by an investment
banker or other appropriate expert of national reputation selected by the Creditor (which investment banker or other expert shall not have been engaged or otherwise employed by the Creditor within one (1) year of the date of such engagement
hereunder) and reasonably acceptable to the Maker, with the costs of such appraisal to be borne by the Maker. 

  
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 (F) Other Action Affecting Conversion Price. If the Maker takes any action affecting the
Common Stock after the date hereof that would be covered by this Section 5, but for the manner in which such action is taken or structured, which would in any way diminish the value of this Note then the Conversion Price shall be
adjusted in such manner as the Board of Directors of the Maker shall in good faith determine to be equitable under the circumstances. 
 (G)
Record Date. In case the Maker shall take a record of the holders of its Common Stock for the purpose of entitling them (i) to receive a dividend or other distribution payable in Common Stock, Options or Convertible Securities or
(ii) to subscribe for or purchase Common Stock, Options or Convertible Securities, then such record date shall be deemed to be the date of the issue or sale of the shares of Common Stock deemed to have been issued or sold upon the declaration
of such dividend or the making of such other distribution or the date of the granting of such right of subscription or purchase, as the case may be, provided, however, that any such adjustment in the Conversion Price shall be reversed or shall not
become effective, as applicable, if the Maker abandons the action to which the record date pertains. 
 (H) Treasury Shares. The
number of shares of Common Stock outstanding at any given time shall not include shares owned or held by or for the account of the Maker or any of its wholly owned Subsidiaries, and the disposition of any such shares (other than the cancellation or
retirement thereof) shall be considered an issue or sale of Common Stock for the purpose of this subsection (iv). 
 (v) Excluded
Issuances. Notwithstanding anything to the contrary contained herein, the Maker shall not be required to make any adjustment of the Conversion Price in the case of the issuance of (A) Common Stock, Options or Convertible Securities issued
to employees or consultants of the Maker in connection with their employment or engagement by the Maker pursuant to an equity compensation plan in effect as of April 26, 2013, or as approved by the Board of Directors, which are granted in the
ordinary course of business and consistent with past practice; (B) Common Stock or Convertible Securities to employees or consultants of the Maker in connection with their employment or engagement by the Maker pursuant to an equity purchase
plan in effect as of April 26, 2013, or as approved by the Board of Directors, which are granted in the ordinary course of business and consistent with past practice or (C) Common Stock upon the conversion or exercise of any warrants
outstanding on the date hereof (collectively, “Excluded Issuances”). 

  
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 (vi) Weighted Average Adjustment for Issuances. In the event that at any time or from time
to time the Maker shall issue or sell Common Stock, Options or Convertible Securities subject to Section 5(d)(iv) for no consideration or for a per share consideration that is greater than the applicable Conversion Price at the time of
such issuance or sale but less at the time of such issuance or sale than the Daily Market Price, then the Conversion Price in effect immediately prior to each such issuance or sale will immediately be reduced to the price determined by multiplying
the Conversion Price, in effect immediately prior to such issuance or sale, by a fraction, (A) the numerator of which shall be (x) the number of shares of Common Stock outstanding immediately prior to such issuance or sale plus
(y) the number of shares of Common Stock which the aggregate consideration received by the Maker for the total number of such additional shares of Common Stock so issued or sold would purchase at the Daily Market Price on the last Trading Day
immediately preceding such issuance or sale and (B) the denominator of which shall be the number of shares of Common Stock outstanding immediately after such issue or sale. 

(e) Fractional Shares. Upon a conversion hereunder, the Maker shall not be required to issue stock certificates representing fractions
of shares of the Common Stock, but may if otherwise permitted, make a cash payment in respect of any final fraction of a share based on the closing bid price at such time. If the Maker elects not, or is unable, to make such a cash payment, the
Creditor shall be entitled to receive, in lieu of the final fraction of a share, one whole share of Common Stock. 
 (f) Notice of
Adjustments. Upon the occurrence of each adjustment or readjustment of the Conversion Price pursuant to this Section 5, the Maker, at its own expense, shall promptly compute such adjustment or readjustment and prepare and furnish to
each Creditor a certificate setting forth such adjustment or readjustment and showing in detail the facts upon which such adjustment or readjustment is based. The Maker shall, upon the written request at any time of the Creditor, furnish to such
Creditor a like certificate setting forth (i) such adjustment or readjustment, (ii) the Conversion Price at the time in effect and (iii) the number of shares of Common Stock and the amount, if any, of other securities or property
which at the time would be received upon conversion of this Note. 
 6. Definitions. As used herein: 

“Affiliate” has the meaning ascribed to such term in the Facility. 

“Board of Directors” means the board of directors of the Maker. 

“Bridge Notes” means the Second Amended and Restated Senior Secured Bridge Promissory Notes, dated as of the date hereof,
issued by the Maker, together with any notes issued as paid-in-kind interest in respect thereof. 
 “Business Day” means
any day that is not a Saturday, a Sunday or a day on which banks are required or permitted to be closed in the State of New York. 

“Cash Equivalents” has the meaning ascribed to such term in the Facility. 

  
 9 

 “Collateral” has the meaning ascribed to such term in Section 2.1 of the
Security Agreement. 
 “Common Stock” means the Maker’s common stock, par value $0.01 per share. 

“Convertible Notes” means the Second Amended and Restated 13% Senior Secured Convertible Notes, dated as of the date hereof,
issued by the Maker, together with any notes issued as paid-in-kind interest in respect thereof. 
 “Conversion Amount”
means the portion of the principal amount of this Note being converted plus any accrued and unpaid interest thereon, if any, through the Conversion Date each as specified in the Notice of Conversion. 

“Conversion Date” means, for any conversion, the date specified in the Notice of Conversion so long as the copy of the Notice
of Conversion is faxed (or delivered by other means resulting in notice) to the Maker at or before 11:59 p.m., New York City time, on the Conversion Date indicated in the Notice of Conversion; provided, however, that if the Notice of Conversion is
not so faxed or otherwise delivered before such time, then the Conversion Date shall be the date the Creditor faxes or otherwise delivers the Notice of Conversion to the Maker. 

“Conversion Price” means $0.50 per share of Common Stock, subject to adjustments as set forth herein. 

“Daily Market Price” means, as of any date of determination, the closing sale price for the Common Stock, for the Trading Day
of such date of determination (subject to equitable adjustment for any stock splits, stock dividends, reclassifications or similar events during such Trading Day or that are not otherwise reflected in such closing price and further subject to
adjustment as provided herein) on the principal United States securities exchange or trading market where the Common Stock is listed or traded as reported by Bloomberg, or if the foregoing does not apply, the closing sale price for the Common Stock
on the OTC Bulletin Board for such security as reported by Bloomberg, or, if no sale price is reported for such security by Bloomberg, the closing sale price as reported in the “pink sheets” by the Pink Sheets LLC, in each case for such
date or, if such date was not a Trading Day for such security, on the next preceding date which was a Trading Day. If the Daily Market Price cannot be calculated for such security as of either of such dates on any of the foregoing bases, the Daily
Market Price of such security on such date shall be the fair market value as reasonably determined by an investment banking firm selected by the Creditor and reasonably acceptable to the Maker, with the costs of such appraisal to be borne by the
Maker. 
 “Designated Product(s)” means an oral product for human use that includes SNAC and Vitamin B12 (in any and all
dosages and forms), any Related Products, and/or any line extension of any of the foregoing. 
 “Dietary Supplement” shall
have the meaning as currently set forth in the federal Food, Drug, and Cosmetic Act, at 21 U.S.C. § 321(ff). 

“Facility” means that certain senior secured loan facility, dated as of the date hereof, by and between the MHR Funds and the
Maker, as amended from time to time. 
 “Governmental Authority” means any government or political subdivision or
department thereof, any entity exercising executive, legislative, judicial, regulatory, taxing or administrative functions of, or pertaining to, government, any governmental or regulatory body, any
self-regulatory body, commission, board, bureau, agency or instrumentality, or any court or arbitrator or alternative dispute resolution body, in each case whether federal, state, local or foreign. 

  
 10 

 “Indebtedness” shall have the meaning ascribed to such term in the Facility.

 “Lien” has the meaning ascribed to such term in the Facility. 

“Loan Documents” means Reimbursement Notes, the Royalty Agreement, the Security Documents and any certificates, instruments,
agreements or other documents executed in connection herewith or therewith. 
 “Maturity Date” means the earlier of
(a) March 31, 2022 and (b) immediately prior to the time that any amounts outstanding under the Facility are repaid. 

“Medical Food” shall have the meaning as currently set forth in the federal Food, Drug, and Cosmetic Act, at 21 U.S.C. §
360ee(b)(4). 
 “MHR Funds” means MHR Capital Partners Master Account LP, a limited partnership organized in Anguilla,
British West Indies, MHR Capital Partners (100) LP, a Delaware limited partnership, MHR Institutional Partners II LP, a Delaware limited partnership and MHR Institutional Partners IIA LP, a Delaware limited partnership. 

“Non-Domestic Intellectual Property” has the meaning ascribed to such term in the Facility. 

“Perfected Lien” has the meaning ascribed to such term in the Facility. 

“Person” means any corporation, limited liability company, natural person, firm, joint venture, partnership, trust,
unincorporated organization or government, or any political subdivision, department or agency of any Governmental Authority. 

“Reimbursement Notes” means this Note and the other senior secured convertible reimbursement promissory notes, dated as of
the date hereof, issued by the Maker, including any notes issued as paid-in-kind interest in respect thereof, on terms substantially similar to this Note (other than the principal amount outstanding thereon), as amended from time to time. 

“Related Product” shall mean any Dietary Supplement, Medical Food or drug, whether available over-the-counter or by
prescription, in any dosage form, strength or route or mode of administration, containing Vitamin B12, whether in combination with any other vitamin, mineral, nutrient, Dietary Supplement, Medical Food, drug or active or inactive pharmaceutical
ingredient or otherwise, and including SNAC or any other similar agent for improved or different bioavailability using the Maker’s proprietary Eligen® technology or any other technology
owned or licensed by the Maker or any of its Subsidiaries. 
 “Royalty” means any and all amounts payable by the Maker
pursuant to the Royalty Agreement. 
 “Royalty Agreement” means that certain Royalty Agreement, dated as of the date
hereof, among the Maker and the MHR Funds. 
 “Security Documents” has the meaning ascribed to such term in the Facility.

  
 11 

 “SNAC” means the Maker’s proprietary Eligen® technology carrier as set forth on Exhibit F to the Facility. 

“Subsidiary” shall have the meaning ascribed to such term in the Facility. 

“Trading Day” shall mean any day on which the principal United States securities exchange or trading market where the Common
Stock is then listed or traded, is open for trading. 
 7. Payments. 

(a) Creditor may, at its option, apply the amount of any payment of principal or interest on account of this Note as consideration for the
purchase of any securities that may, from time to time, be issued by the Maker to the Creditor for value. 
 (b) All payments shall first be
applied to any interest then due, if any, with the balance remaining applied to principal. Notwithstanding any provision contained herein or contained in any other instrument or agreement now or hereafter executed in connection with this Note, the
maximum amount of interest and other charges in the nature thereof contracted for, or payable hereunder or thereunder, shall not exceed the maximum amount which may be lawfully contracted for, charged and received in this transaction, all as
determined by the final judgment of a court of competent jurisdiction, including all appeals therefrom, and in event the interest rate is determined to be unlawful, such interest rate shall be computed at the highest rate permitted by applicable
law. To the extent any interest received by Creditor exceeds the maximum amount permitted, such payment shall be credited to principal, and any excess remaining after full payment of principal shall be refunded to Maker. The Maker agrees to pay on
demand all costs and expenses incurred by the holder hereof, including, without limitation, all reasonable attorneys’ fees and all court costs, for the collection and enforcement of this Note and the indebtedness evidenced hereby. If the
Maturity Date is a day other than a Business Day, the maturity thereof shall be extended to the next succeeding Business Day. 
 8. Form of Payment.
All payments of principal, interest, fees and other amounts due hereunder shall be made by the Maker in U.S. Dollars by wire transfer to the account designated by the Creditor or by any other method approved in advance in writing by the Creditor

 9. Events of Default. Notwithstanding anything to the contrary contained herein, this Note shall become immediately due and payable upon the
occurrence of (and the Maturity Date shall be correspondingly accelerated to the date of such occurrence) any of the following (each, an “Event of Default”): 

(i) (A) A court enters a decree or order for relief with respect to the Maker in an involuntary case under the U.S. Bankruptcy Code,
which decree or order is not stayed or other similar relief is not granted under any applicable federal or state law; or (B) the continuance of any of the following events for 45 days unless dismissed, bonded or discharged: (x) an
involuntary case is commenced against the Maker, under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect; or (y) a decree or order of a court for the appointment of a receiver, liquidator, sequestrator,
trustee, custodian or other officer having similar powers over the Maker, or over all or a substantial part of its property, is entered; or (z) a receiver, trustee or other custodian is appointed without the consent of the Maker, for all or a
substantial part of the property of the Maker; 
 (ii) (A) The Maker commences a voluntary case under the U.S. Bankruptcy Code, or
consents to the entry of an order for relief in an involuntary case or to the conversion of an involuntary case to a voluntary case under any such law or consents to the appointment of or taking possession by a receiver, trustee or other custodian
for all or a substantial part of its property; or (B) the Maker makes any assignment for the benefit of creditors; or (C) the Board of Directors of the Maker adopts any resolution or otherwise authorizes action to approve any of the
actions referred to in this paragraph; 

  
 12 

 (iii) (A) Individuals who, as of the date of this Note, constitute the Board of Directors
(the “Board”) of the Maker (the “Incumbent Directors”) cease for any reason to constitute at least a majority of the Board, provided that any person becoming a director subsequent to the date of this Note whose
election or nomination for election was approved by a vote of a majority of the Incumbent Directors then on the Board shall be an Incumbent Director; provided, however, that no individual initially elected or nominated as a director of the
Maker as a result of an actual or threatened election contest with respect to directors or as a result of any other actual or threatened solicitation of proxies or consents by or on behalf of any person other than the Board shall be deemed to be an
Incumbent Director; (B) any “person” (as such term is defined in Section 3(a)(9) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) other than the Creditor and its affiliates becomes a
“beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Maker representing 50% or more of the combined voting power of the Maker’s then outstanding securities eligible to vote
generally in the election of directors; and (C) the Maker sells or otherwise disposes of all or a substantial part of its assets in one transaction or in a series of related transactions or ceases to conduct all or a substantial part of its
business as now conducted, or merges or consolidates with any other person or entity without the prior written consent of the Creditor; 

(iv) The Maker fails to pay any amount under this Note as and when that amount becomes due and payable pursuant to this Note; 

(v) The Maker fails to perform or observe any covenant or agreement under this Note other than those referred to in Section 9(iv) hereof
and does not remedy such failure on or before the tenth (10th) day after it occurs; 

(vi) Any of the Security Documents shall cease, for any reason, to be in full force and effect; or (ii) the Lien created by any of the
Security Documents shall fail to constitute a Perfected Lien in the Collateral; provided, that (A) solely with respect to any individual item of Collateral having a fair market value of $25,000 (as reasonably determined by the Maker in good
faith and reasonably agreed to by the Creditor) or less, such failure to maintain a Perfected Lien in such item of Collateral shall not constitute an Event of Default unless the Maker does not remedy such failure on or before the 5th day after such
failure occurs, (B) such failure to maintain a Perfected Lien in such item of Collateral shall not constitute an Event of Default if such failure results solely from any action or failure to act on the part of the Creditor (following notice
thereof from the Maker) to maintain such Perfected Lien and which action or failure to act contravenes the provisions of this Note, the other Loan Documents or applicable law, and (C) notwithstanding anything herein or in any Loan Document to
the contrary, the failure to perfect (or attain the functional equivalent of perfection of) the security interest granted to the Creditor in any Non-Domestic Intellectual Property constituting Collateral prior to the date required therefor pursuant
to Section 7(dd) of the Convertible Notes, shall not constitute an Event of Default; 
 (vii) The Maker makes any payment to reduce any
amounts outstanding under the Facility; 
 (viii) Any Event of Default (as such term is defined in the Facility, the Convertible Notes or
the Bridge Notes, as applicable) shall occur thereunder, or the Maker or any Subsidiary: (A) fails to pay any of its other Indebtedness as and when that Indebtedness becomes due and payable; or (B) fails to perform or observe any covenant
or agreement to be performed or observed by it contained in any other agreement or in any instrument evidencing any of its other Indebtedness (and any cure period under such other agreement or instrument shall have expired) and, as a result of the
failure, any other party to that agreement or instrument is entitled to exercise the right to accelerate the maturity of any amount owing thereunder; or 

  
 13 

 (ix) The Maker fails to pay any Royalty when due pursuant to, or breaches any of its obligations
under, the terms of the Royalty Agreement. 
 10. Right of Set-off. The obligations of the Maker to make the payments provided for in this Note are
absolute and unconditional and not subject to any defense, set-off, counterclaim, rescission, recoupment or adjustment whatsoever. The Maker hereby: (a) waives presentment, demand, protest, suretyship defenses and defenses in the nature
thereof; (b) waives any defenses based upon and specifically assents to any and all extensions and postponements of the time for payment, changes in terms and conditions and all other indulgences and forbearances which may be granted by the
holder to any party now or hereafter liable hereunder; and (c) agrees to be bound by all of the terms contained in this Note. 
 11. Governing
Law. All rights and obligations hereunder shall be governed by the laws of the State of New York, U.S.A. This Note is executed as, and shall have the effect of, a sealed instrument. 

12. Invalidity. In the event any one or more of the provisions of this Note shall for any reason be held to be invalid, illegal or unenforceable, in
whole or in part or in any respect, or in the event that any one or more of the provisions of this Note operates to invalidate this Note, then and in either of those events, such provision or provisions only shall be deemed null and void and shall
not affect any other provision of this Note, and the remaining provisions of this Note shall remain operative and in full force and effect and shall in no way be affected, prejudiced or disturbed thereby. 

13. Amendments, Assignments, etc. This Note may not be amended, supplemented, modified or terminated orally, but only by an agreement in writing signed
by the Maker and the Creditor. This Note shall inure to the benefit of and be binding upon the successors and permitted assigns of the parties hereto. The Maker may not assign any of its rights or obligations under this Note without the prior
written consent of the Creditor. The Creditor may assign all or a portion of its rights or obligations under this Note without the prior written consent of the Maker. 

14. Jurisdiction. For purposes of any action or proceeding involving this Note, Maker hereby expressly consents to the exclusive jurisdiction of all
federal and state courts located in the State of New York and consents that any order, process, notice of motion or other application to or by any of said courts or a judge thereof may be served within or without such court’s jurisdiction by
registered mail or by personal service, provided a reasonable time for appearance is allowed (but not less than the time otherwise afforded by any law or rule), and waives any right to contest the appropriateness of any action brought in any
such court based upon lack of personal jurisdiction, improper venue or forum non conveniens. The Maker hereby waives trial by jury in any litigation in any court with respect to, in connection with, or arising out of this Note or any
instrument or document delivered pursuant to this Note, or the validity, protection, interpretation, collection or enforcement thereof, or any other claim or dispute howsoever arising, between the Maker and the Creditor. 

15. Replacement of Note. Upon the loss, theft, destruction or mutilation of this Note, and upon the execution and delivery by the Creditor to the Maker
of an affidavit in form and substance reasonably acceptable to the Maker attesting to such loss, theft, destruction or mutilation, as the case may be, and an agreement, in form and substance reasonably acceptable to the Maker indemnifying and
holding the Maker harmless from and against any liability or damages arising therefrom, the Maker shall execute and deliver in lieu thereof a new Note, dated the date of the Note being replaced, in the same principal amount. 

  
 14 

 16. Waivers. No delay or omission on the part of the holder in exercising any right hereunder (or any
right under any instrument or agreement executed in connection herewith or which is given or may be given to secure the indebtedness evidenced hereby) shall operate as a waiver of such right, or of any other right, of such holder, nor shall any
delay, omission or waiver on any one occasion be deemed to be a bar to, or waiver of, the same or of any other right on any future occasion. 
 17.
Notices. All notices and other communications given to any party hereto pursuant to this Note shall be in writing and shall be delivered by hand, fax or email (and in the case of fax or email, receipt confirmed immediately via telephone), or
mailed first class postage prepaid, registered or certified mail, addressed as follows: 
 (a) If to the Maker, to: 

Emisphere Technologies, Inc. 
 4
Becker Farm Road 
 Suite 103 

Roseland, NJ 07068 
 Attention:
Chief Financial Officer 
 Phone: (973) 532-8000 

Fax: (973) 422-0125 
 Email:
mgarone@emisphere.com 
 with a copy to: 

Lowenstein Sandler LLP 
 65
Livingston Avenue 
 Roseland, NJ 07068 

Attention: Michael H. Lerner, Esq. 

Phone: (973) 575-2500 
 Fax:
(973) 575-2400 
 Email: mlerner@lowenstein.com 

(b) If to the Creditor, to: 

c/o MHR Fund Management LLC 

40 West 57th Street, 24th Floor 

New York, NY 10019 
 Fax number:
(212) 262-9356 
 Attention: Janet Yeung 

Phone: (212) 262-0005 
 Fax:
(212) 262-9356 
 Email: jyeung@mhrfund.com 

with a copy to: 

O’Melveny & Myers LLP 

7 Times Square 
 New York, NY
10036 
 Attn: David I. Schultz 

Phone: (212) 326-2000 
 Fax:
(212) 326-2061 
 Email: dschultz@omm.com 
  

  
 15 

 Each such notice or other communication shall for all purposes be treated as being effective or having been given
when delivered, if delivered personally, by e-mail or facsimile with confirmation of receipt or if by overnight courier or, if sent by mail, upon actual receipt. 

18. Headings. The headings of the sections of this Note are inserted for convenience only and do not constitute a part of this Note. 

19. Further Assurances. The Maker shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and
deliver all such other agreements, certificates, instruments and documents (including without limitation any intercreditor agreements and subordination agreements), as the Creditor may reasonably request in order to carry out the intent and
accomplish the purposes of this Note and the consummation of the transactions contemplated hereby. 
 20. Information Reporting. Promptly upon the
request of the Creditor, the Maker shall furnish in writing to the Creditor such information as reasonably requested in connection with any calculation to be made in connection with this Note, including any calculation performed in connection with
any mandatory redemption or other payment under this Note. 
 21. Priority of Reimbursement Notes. No payment may be made to reduce any amounts
outstanding under the Facility at any time when any of the Reimbursement Notes are outstanding. 
 22. Nature of Obligations. The Obligations under
this Note and all other Second Amended and Restated Reimbursement Notes issued by the Maker in a form substantially similar to this Note are executed and delivered in substitution for, but not in satisfaction of, the obligations under the Existing
Notes (collectively, the “Precedent Obligations”) and this Note shall not constitute a refinancing, substitution or novation of the Precedent Obligations. 

[Signature Page Follows] 

  
 16 

 WITNESS the hand and seal of the undersigned on the day and year first above written. 

 

			
	 MAKER:
  

EMISPHERE TECHNOLOGIES, INC.

		
	By:	 	 
		 	 Name: 
 Title: 

  

  

 EXHIBIT A 

NOTICE OF CONVERSION

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