Document:

Registration Rights Agreement

 EXHIBIT 10.1 

REGISTRATION RIGHTS AGREEMENT 

BY AND AMONG 

MDRNA, INC., 

AND 

THE INVESTORS SET FORTH ON SCHEDULE I HERETO 

 
  

Dated as of July 21, 2010 
  

 

 TABLE OF CONTENTS 

 

					
	 	  	 	  	Page
			
	Section 1.	  	Certain Definitions	  	1
			
	Section 2.	  	Demand Registration	  	4
			
	Section 3.	  	Piggyback Registrations	  	6
			
	Section 4.	  	S-3 Shelf Registration	  	7
			
	Section 5.	  	Suspension Periods	  	8
			
	Section 6.	  	Registration Procedures	  	9
			
	Section 7.	  	Registration Expenses	  	13
			
	Section 8.	  	Indemnification	  	14
			
	Section 9.	  	Securities Act Restrictions	  	16
			
	Section 10.	  	Transfers of Rights	  	16
			
	Section 11.	  	Miscellaneous	  	17
		
	ANNEX A – Plan of Distribution	  	A-1
	ANNEX B – Selling Securityholder Notice and Questionnaire	  	B-1

 THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), is made and entered
into as of July 21, 2010, by and between MDRNA, Inc., a Delaware corporation (“Company”), and each of the investors set forth on Schedule I hereto (the “Investors”, and each an
“Investor”). 
 WHEREAS, on March 31, 2010, the Company, a wholly owned subsidiary of the Company
(“Merger Sub”), and Cequent Pharmaceuticals, Inc. (“Cequent”) entered into an Agreement and Plan of Merger Agreement, pursuant to which upon consummation Cequent shall merge (the “Merger”) with
Merger Sub and be the surviving corporation, and Company shall issue shares of Company Common Stock, par value $0.006 per share (the “Common Shares”) as the merger consideration to the Investors (“Merger
Securities”), 
 WHEREAS, a condition to the consummation of the Merger is that the Company concurrently enter into
this Agreement with the Investors with respect to registration rights, 
 WHEREAS, on July 21, 2010, the Merger was
consummated and the Company issued an aggregate of 9,882,853 Merger Securities to the Investors, and, as of the date hereof, the Company and the Investors desire to enter into this Agreement, 

NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valid consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties to this Agreement hereby agree as follows: 

Section 1. Certain Definitions. 

In addition to the terms defined elsewhere in this Agreement, the following terms shall have the following meanings: 

“Affiliate” of any Person means any other Person which directly, or indirectly through one or more intermediaries,
controls, or is controlled by, or is under common control with, such Person. The term “control” (including the terms “controlling,” “controlled” and “under common control with”) as used with respect to any
Person means the possession, direct or indirect, of the power to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or otherwise. 

“Agreement” means this Registration Rights Agreement, including all amendments, modifications and supplements and any
exhibits or schedules to any of the foregoing, and shall refer to this Registration Rights Agreement as the same may be in effect at the time such reference becomes operative. 

“beneficially own” means, with respect to any Person, securities of which such Person or any of such Person’s
Affiliates, directly or indirectly, has “beneficial ownership” as determined pursuant to Rule 13d-3 and Rule 13d-5 of the Exchange Act, including securities beneficially owned by others with whom such Person or any of its
Affiliates has agreed to act together for the purpose of acquiring, holding, voting or disposing of such securities; provided that a Person shall not be deemed to “beneficially own” (i) securities tendered pursuant to a tender
or exchange offer made by such Person or any of such Person’s Affiliates until such tendered securities are accepted for payment, purchase or exchange, or (ii) any security as a result of an oral or written

 
agreement, arrangement or understanding to vote such security if such agreement, arrangement or understanding: (a) arises solely from a revocable proxy given in response to a public proxy or
consent solicitation made pursuant to, and in accordance with, the applicable provisions of the Exchange Act, and (b) is not also then reportable by such Person on Schedule 13D under the Exchange Act (or any comparable or successor
report). Without limiting the foregoing, a Person shall be deemed to be the beneficial owner of all Registrable Shares owned of record by any majority-owned subsidiary of such Person. 

“Closing Date” has the meaning set forth in the Merger Agreement. 

“Common Shares” has the meaning set forth in the first Recital hereto. 

“Company” has the meaning set forth in the introductory paragraph. 

“Demanding Investor” has the meaning set forth in Section 2(c). 

“Demand Registration” has the meaning set forth in Section 2(a). 

“Demand Registration Statement” has the meaning set forth in Section 2(a). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Form S-3” means a registration statement on Form S-3 under the Securities Act or such successor forms thereto
permitting registration of securities under the Securities Act. 
 “Governmental Entity” means any national,
federal, state, municipal, local, territorial, foreign or other government or any department, commission, board, bureau, agency, regulatory authority or instrumentality thereof, or any court, judicial, administrative or arbitral body or public or
private tribunal. 
 “Investor” or “Investors” means the Person named as such in the first
paragraph of this Agreement and provided, that if any Transferee of Registrable Shares succeeds to the rights and obligations of such Investor or Investors hereunder in accordance with Section 10, “Investor” or
“Investors” shall also mean such Transferees. 
 “Investor’s Counsel” has the meaning set forth
in Section 6(a)(i). 
 “Merger Securities” has the meaning set forth in the first Recital hereto, together
with the Shares underlying any warrants assumed in the Merger. 
 “Minimum Amount” means $5 million.

 “Transferee” has the meaning set forth in Section 10(a). 

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, trust,
incorporated organization, association, corporation, institution, public benefit corporation, Governmental Entity or any other entity. 

“Piggyback Event” has the meaning set forth in Section 3(a). 

 

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 “Prospectus” means the prospectus or prospectuses (whether preliminary or
final) included in any Registration Statement and relating to Registrable Shares, as amended or supplemented and including all material incorporated by reference in such prospectus or prospectuses. 

“Registrable Shares” means, at any time, with respect to a particular Investor, (i) the Merger Securities held of
record by such Investor at such time and (ii) any securities issued by the Company after the date hereof in respect of the Shares referred to in clause (i) by way of a share dividend or share split or other distribution or in connection
with a combination of shares, recapitalization, merger, consolidation or other reorganization, but excluding all such Common Shares and such other securities held by such Investor at a time when such securities are eligible for resale by such
Investor pursuant to Rule 144 under the Securities Act without limitation thereunder on volume or manner of sale. 

“Registration Expenses” has the meaning set forth in Section 7(a). 

“Registration Statement” means any registration statement of the Company which covers any of the Registrable Shares
pursuant to the provisions of this Agreement, including the Prospectus, amendments and supplements to such Registration Statement, including post-effective amendments, all exhibits and all documents incorporated by reference in such Registration
Statement. 
 “S-3 Shelf Registration” has the meaning set forth in Section 4(a). 

“S-3 Shelf Registration Statement” has the meaning set forth in Section 4(a). 

“SEC” means the Securities and Exchange Commission or any successor agency. 

“Securities Act” means the Securities Act of 1933, as amended. 

“Shares” means any of the Common Shares. If at any time Registrable Shares include securities of the Company other than
Common Shares, then, when referring to Shares other than Registrable Shares, “Shares” shall include the class or classes of such other securities of the Company. 

“Shelf Effectiveness Deadline” has the meaning set forth in Section 4(a). 

“Shelf Takedown” has the meaning set forth in Section 3(a). 

“Suspension Period” has the meaning set forth in Section 5. 

“Termination Date” means with respect to a particular Investor the first date on which such Investor no longer owns any
Registrable Shares or such Investor is no longer an “Investor”. 
 “underwritten offering” means a
registered offering in which securities of the Company are sold to one or more underwriters on a firm-commitment basis for reoffering to the public, and “underwritten Shelf Takedown” means an underwritten offering effected pursuant
to an S-3 Shelf Registration. 
  

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 In addition to the above definitions, unless the context requires otherwise: 

(i) any reference to any statute, regulation, rule or form as of any time shall mean such statute, regulation, rule or
form as amended or modified and shall also include any successor statute, regulation, rule or form from time to time; 

(ii) “including” shall be construed as inclusive without limitation, in each case notwithstanding the absence of
any express statement to such effect, or the presence of such express statement in some contexts and not in others; 

(iii) references to “Section” are references to Sections of this Agreement; 

(iv) words such as “herein”, “hereof”, “hereinafter” and “hereby” when used in
this Agreement refer to this Agreement as a whole; 
 (v) references to “business day” mean a business
day in The City of Boston, Massachusetts; and 
 (vi) references to “dollars” and “$” mean
U.S. dollars. 
 Section 2. Demand Registration. 

(a) Right to Request Registration. The following demand registration rights will apply only if the Company fails to provide the
resale registration rights set forth in Section 4, as follows: Subject to the provisions hereof and until the applicable Termination Date, if the Company has not filed, and caused to be effective and maintained the effectiveness of an S-3 Shelf
Registration Statement, the Investors may request in writing registration for resale under the Securities Act of all or part of its Registrable Shares (a “Demand Registration”); provided, however, that (based on the
then-current market prices) the number of Registrable Shares included in the Demand Registration would, if fully sold, reasonably be expected to yield gross proceeds of at least the Minimum Amount. Subject to Section 2(d) and Section 5
below, the Company shall use reasonable best efforts (i) to file a Registration Statement registering for resale such number of Registrable Shares as requested to be so registered pursuant to this Section 2(a) (a “Demand
Registration Statement”) within 30 days after Investors or their Transferees’ request therefor and (ii) to cause such Demand Registration Statement to be declared effective by the SEC as soon as practical thereafter. 

(b) Number of Demand Registrations. Subject to the limitations of Sections 2(a) and 2(d) below, the Investors shall be
entitled to request not more than three (3) Demand Registrations under this Agreement and not more than one Demand Registration in any rolling period of 180 days. A Registration Statement shall not count as a permitted Demand Registration
unless and until it has become effective and Investors are able to register and sell the Registrable Shares requested to be included in such registration. 

(c) Priority on Demand Registrations. The Company shall not include Shares other than Registrable Shares in a Demand Registration.
If such Demand Registration is an underwritten offering, and the managing underwriter(s) of the requested Demand Registration advise the Company and the Investor(s) requesting such Demand Registration that in their

  

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opinion the number of Shares proposed to be included in the Demand Registration exceeds the number of Shares which can be sold in such underwritten offering, or securities other than Common
Shares cannot be sold in the offering, in either case without materially delaying or jeopardizing the success of the offering (including the price per share of the Shares proposed to be sold in such underwritten offering), the Company shall include
in such Demand Registration (i) first, the number of Registrable Shares that Investor who initiated the demand (the “Demanding Investor”) proposes to sell, and (ii) second, the number of Shares proposed to be included
therein by the other Investors. If the number of Shares which can be so sold is less than the number of Shares proposed to be registered pursuant to clause (i) above by the Demanding Investor, the amount of Shares to be sold shall be fully
allocated to the Demanding Investor. 
 (d) Restrictions on Demand Registrations. Notwithstanding the foregoing, the
Company shall not be obligated to proceed with a Demand Registration if the offering to be effected pursuant to such registration can be effected at that time pursuant to a then currently effective S-3 Shelf Registration previously filed by the
Company in accordance with Section 4. 
 (e) Underwritten Offerings. Investors and their Transferees shall be
entitled to request an underwritten offering pursuant to a Demand Registration, but only if the number of Registrable Shares to be sold in the offering would reasonably be expected to yield gross proceeds of at least the Minimum Amount (based on
then-current market prices) and only if the request is not made within sixty (60) days after the Investor has sold Shares in another underwritten registered offering pursuant to Section 2 or Section 4 hereof. If any of the Registrable
Shares covered by a Demand Registration are to be sold in an underwritten offering, the Investors shall have the right to select the managing underwriter or underwriters to lead the offering, subject to the Company’s consent, not to be
unreasonably withheld. 
 (f) Effective Period of Demand Registrations. Upon the date of effectiveness of any Demand
Registration for an underwritten offering and if such offering is priced promptly on or after such date, the Company shall use reasonable best efforts to keep such Demand Registration Statement effective for a period equal to 60 days from such date
or such shorter period which shall terminate when all of the Registrable Shares covered by such Demand Registration have been sold by the Investors pursuant to such Demand Registration. If the Company shall withdraw any Demand Registration pursuant
to Section 5 before such 60 days end and before all of the Registrable Shares covered by such Demand Registration have been sold pursuant thereto, the Investors shall be entitled to a replacement Demand Registration which shall be subject
to all of the provisions of this Agreement. A Demand Registration shall not count against the limit on the number of such registrations set forth in Section 2(b) if (i) after the applicable Registration Statement has become effective, such
Registration Statement or the related offer, sale or distribution of Registrable Shares thereunder becomes the subject of any stop order, injunction or other order or restriction imposed by the SEC or any other governmental agency or court for any
reason not attributable to the Investors or their Affiliates (other than the Company and its controlled Affiliates) and such interference is not thereafter eliminated so as to permit the completion of the contemplated distribution of Registrable
Shares or (ii) in the case of an underwritten offering, the conditions specified in the related underwriting agreement, if any, are not satisfied or waived for any reason not attributable to the Investors or their Affiliates (other than the
Company and its controlled Affiliates), and as a result of any such circumstances described in clause (i) or (ii), less than all of the Registrable Shares covered by the Registration Statement are sold by the Investors pursuant to such
Registration Statement. 
  

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 Section 3. Piggyback Events. 

(a) Right to Piggyback. Whenever prior to the applicable Termination Date the Company proposes (i) to register any Shares
under the Securities Act (other than on a registration statement on Form S-8, F-8, S-4 or F-4), whether for its own account or for the account of one or more holders of Shares, and the form of registration statement to be used may be used for
any registration of Registrable Shares or (ii) to sell Shares that have already been registered “off the shelf” by means of a prospectus supplement (a “Shelf Takedown”) (each a “Piggyback Event”), the
Company shall give prompt written notice to the Investors of its intention to effect such a registration and/or Shelf Takedown and, subject to Sections 3(b) and 3(c), shall include in such registration statement and in any offering of Shares to
be made pursuant to that registration statement and/or Shelf Takedown all Registrable Shares with respect to which the Company has received a written request for inclusion therein from any Investor within 20 days after such Investor’s
receipt of the Company’s notice (provided that only Registrable Shares of the same class or classes as the Shares being registered and/or taken-down may be included). The Company shall have no obligation to proceed with any Piggyback
Event and may abandon, terminate and/or withdraw such registration and/or Shelf Takedown for any reason at any time prior to the pricing thereof. If the Company or any other Person other than the Investors proposes to sell Shares in an underwritten
offering pursuant to a registration statement on Form S-3 under the Securities Act, such offering shall be treated as a primary or secondary underwritten offering pursuant to a Piggyback Event. Notwithstanding the foregoing, no Investor will have
any rights under this Section 3 in respect of an underwritten Shelf Takedown that has been requested by another Investor, and any such underwritten Shelf Takedown will be subject to Section 4(c) hereof. 

(b) Priority on Primary Piggyback Events. If a Piggyback Event is initiated as a primary underwritten offering on behalf of the
Company and the managing underwriter(s) advise the Company and any Investors (if such Investors have elected to include Registrable Shares in such Piggyback Event) that in their opinion the number of Shares proposed to be included in such offering
exceeds the number of Shares (of any class) which can be sold in such offering without materially delaying or jeopardizing the success of the offering (including the price per share of the Shares proposed to be sold in such offering), the Company
shall include in such registration and offering (i) first, the number of Shares that the Company proposes to sell and (ii) second, the number of Shares requested to be included therein by the Investors pro rata among all such holders on
the basis of the number of Shares held by them on the date the Company gives the notice specified in Section 3(a). 
 (c)
Priority on Secondary Registrations. If a Piggyback Event is initiated as an underwritten registration on behalf of a holder of Shares, and the managing underwriter(s) advise the Company that in their opinion the number of Shares proposed to
be included in such registration exceeds the number of Shares (of any class) (the “Secondary Maximum Number of Shares”) which can be sold in such offering without materially delaying or jeopardizing the success of the offering
(including the price per share of the Shares to be sold in such offering), then the Company shall include in such registration (i) first, the number of Shares requested to be 

 

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included therein by holder(s) requesting such registration, (ii) second, the number of Shares requested to be included therein by any of the Investors (if such Investors have elected to
include Registrable Shares in such Piggyback Event), pro rata among such holders on the basis of the number of Shares held by them on the date the Company gives the notice specified in Section 3(a), and (iii) third, the number of Shares
that the Company proposes to sell, to the extent that, in the case of clauses (ii) and (iii), the Secondary Maximum Number of Shares is not thereby exceeded. 

(d) Selection of Underwriters. If any Piggyback Event is a primary or secondary underwritten offering, the Company (or if the
Person or Persons initiating the Piggyback Event in the context of a secondary underwritten offering have such right, such Person(s)) shall have the right to select the managing underwriter or underwriters to administer any such offering.

 (e) Basis of Participations. No Investor may sell Registrable Shares in any offering pursuant to a Piggyback Event
unless it (a) agrees to sell such Shares on the basis provided in the underwriting or other distribution arrangements approved by the Company and (b) completes and executes all questionnaires, powers of attorney, indemnities, underwriting
agreements, lockups and other documents reasonably required of other participants under the terms of such arrangements. 

Section 4. S-3 Shelf Registration. 

(a) Shelf Registration. The Company shall use reasonable best efforts (i) to file with the SEC a Registration Statement on
Form S-3, with a “Plan of Distribution” substantially in the form set forth as Annex A (an “S-3 Shelf Registration Statement”), for a public offering of all or such portion of the Registrable Shares designated
by any Investor pursuant to Rule 415 promulgated under the Securities Act or otherwise (an “S-3 Shelf Registration”) as soon as practicable, but no later than 45 calendar days from the Closing Date and (ii) to cause such
S-3 Shelf Registration Statement to declared effective within 90 calendar days of the Closing Date (the “Shelf Effectiveness Deadline”) and to thereafter remain effective. The S-3 Shelf Registration Statement shall only include
Registrable Shares. Subject to Section 5 hereof and any applicable Lock-up Agreement, the Investors and their Transferees shall be entitled to sell their Registrable Shares at any time and in any amount in accordance with any of the sale
methods set forth in the “Plan of Distribution” section. However, in the case of a Shelf Takedown from the S-3 Shelf Registration Statement (an “Investor Shelf Takedown”), the provisions of Section 4(b), (c) and
(d) shall govern, as applicable. 
 (b) Right to Effect Shelf Takedowns. The Investors each shall be entitled, at
any time and from time to time when an S-3 Shelf Registration Statement is effective to sell such Registrable Shares as are then registered pursuant to an Investor Shelf Takedown, but only upon not less than five (5) business days’ prior
written notice to the Company, during which period the Company shall be entitled to implement a Suspension Period to the extent then permitted pursuant to Section 5. The Investors each shall give the Company prompt written notice of the
consummation of each Investor Shelf Takedown (whether or not underwritten). For the avoidance of doubt, the parties agree that an Investor Shelf Takedown is a non-exclusive means to effectuate the offer and sale of Registrable Shares under the S-3
Shelf Registration Statement. Subject to Section 5 hereof, the Investors shall have the benefit of all the selling means permitted 

 

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in the S-3 Shelf Registration Statement “Plan of Distribution,” including those that do not constitute Investor Shelf Takedowns (and therefore are not subject to Sections 4(b) and
(c) hereof) because they are offering that do not require the filing of a prospectus supplement based on the existing disclosure in the “Plan of Distribution”, such as ordinary brokerage transactions in the open market (the foregoing
being only an example). Notwithstanding the foregoing, the Company shall be entitled to delay for a period of no more than forty-five (45) days effecting a requested Investor Shelf Takedown if the Company delivers notice to the Investors
requesting such Investor Shelf Takedown within five (5) days of the receipt of such a request that the Company intends to file a registration statement for a public offering of primary Company securities for cash proceeds of at least the
Minimum Amount; provided that the Company shall only be able to deliver such notice once in any six (6) month period. 

(c) Underwritten Shelf Takedowns. The Investors and its Transferees shall be entitled to request, in the aggregate, six
(6) underwritten Investor Shelf Takedown(s) under this Agreement, but only if (i) the number of Registrable Shares to be sold in each such offering would reasonably be expected to yield gross proceeds to such Investor of at least the
Minimum Amount (based on then-current market prices) and (ii) without the Company’s consent, such consent not to be unreasonably withheld, the request is not made within ninety (90) days after such Investor has sold Shares in another
underwritten registered offering pursuant to Section 2 or 4 hereof, as applicable. The Company may not include Shares in an underwritten Investor Shelf Takedown requested by an Investor without such Investor’s prior written consent;
provided that, only in the case of an underwritten Investor Shelf Takedown that includes a “roadshow,” the Investor that requests such underwritten Investor Shelf Takedown shall provide reasonable notice to the other Investors (based on
the then current notice information of the Investors as set forth in the books and records of the Company) and shall give the other Investors a reasonable opportunity to participate in such underwritten Investor Shelf Takedown, subject to
(x) priority equivalent to that found in Section 3(c) and (y) the requirements in Section 3(e). 
 (d)
Selection of Underwriters. In connection with an underwritten Investor Shelf Takedown, the initiating Investor shall have the right to select the managing underwriter or underwriters to lead the offering, subject to the Company’s
consent, not to be unreasonably withheld. 
 (e) Effective Period of S-3 Shelf Registrations. Subject to Section 5
of this Agreement, the Company shall use reasonable best efforts to keep any S-3 Shelf Registration Statement continuously effective until the applicable Termination Date. 

Section 5. Suspension Periods 

(a) Suspension Periods. The Company may delay the filing or effectiveness of, or by written notice to the applicable
Investor(s) suspend the use of, a Registration Statement in conjunction with a Demand Registration or an S-3 Shelf Registration (and, if reasonably required, withdraw any registration statement that has been filed), but in each such case only if the
board of directors of the Company determines in good faith that (x) such delay would enable the Company to avoid disclosure of material information, the disclosure of which at that time would be materially adverse to the Company’s best
interests (including by materially interfering with, or jeopardizing the success of, any pending or proposed material acquisition, disposition or 

 

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reorganization) or (y) obtaining any financial statements (including required consents) required to be included in any such Registration Statement would be impracticable. Any period during
which the Company has delayed a filing, an effective date or the use of a Registration Statement pursuant to this Section 5 is herein called a “Suspension Period”. In no event shall there be more than two Suspension Periods
during any rolling period of 365 days, and the number of days covered by any one Suspension Period shall not exceed 90 days, and the number of days covered by all Suspension Periods shall not exceed 180 days in the aggregate during
any rolling period of 365 days. If pursuant to this Section 5 the Company delays or withdraws a Demand Registration or underwritten Investor Shelf Takedown requested by the applicable Investor, the applicable Investor shall be entitled to
withdraw such request and, if it does so, such request shall not count against the limitation on the number of such registrations set forth in Section 2 or 4. The Company shall provide prompt written notice to the Investors of the commencement
and termination of any Suspension Period (and any withdrawal of a registration statement pursuant to this Section 5), but shall not be obligated under this Agreement to disclose the reasons therefor. The Investors shall keep the existence of
each Suspension Period confidential. 
 Section 6. Registration Procedures. 

(a) In connection with the S-3 Shelf Registration provided for in Section 4 and otherwise whenever any Investor requests that any
Registrable Shares be registered pursuant to this Agreement, the Company shall use reasonable best efforts to effect, as soon as practical as provided herein, the registration and the sale of such Registrable Shares in accordance with the intended
methods of disposition thereof, and, pursuant thereto, the Company shall, as soon as practical as provided herein: 

(i) subject to the other provisions of this Agreement, use reasonable best efforts to prepare and file with the SEC a
Registration Statement with respect to such Registrable Shares and cause such Registration Statement to become effective (unless it is automatically effective upon filing); and before filing a Registration Statement or Prospectus or any amendments
or supplements thereto, furnish to the Investors and the underwriters or other distributors, if any, identified by the applicable Investor copies of all such documents proposed to be filed, including documents incorporated by reference in the
Prospectus and one set of the exhibits incorporated by reference, and the Investors and a single counsel selected by (i) Ampersand 2006 Limited Partnership, (ii) A.M. Pappas Life Science Ventures III, LP and PVIII CEO Fund, LP and
(iii) Novartis BioVentures Ltd. (or in the case of an underwritten Investor Shelf Takedown, a single counsel selected by the Investor requesting such underwritten Investor Shelf Takedown pursuant to Section 4(c)) (“Investor’s
Counsel”) shall have a reasonable opportunity to review and comment on the Registration Statement and each such Prospectus (and each amendment or supplement thereto) before it is filed with the SEC, and the Investors shall have the
opportunity to object to any information pertaining to the Investors that is contained therein and the Company will make the corrections reasonably requested by the Investors with respect to such information prior to filing any Registration
Statement or Prospectus or any amendment or supplement thereto; 
 (ii) use reasonable best efforts to prepare
and file with the SEC such amendments and supplements to such Registration Statement and the Prospectus used in 
  

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connection therewith as may be necessary to comply with the applicable requirements of the Securities Act and to keep such Registration Statement effective for the relevant period required
hereunder, but no longer than is necessary to complete the distribution of the Shares covered by such Registration Statement, and to comply with the applicable requirements of the Securities Act with respect to the disposition of all the Shares
covered by such Registration Statement during such period in accordance with the intended methods of disposition set forth in such Registration Statement; 

(iii) use reasonable best efforts to obtain the withdrawal of any order suspending the effectiveness of any Registration
Statement, or the lifting of any suspension of the qualification or exemption from qualification of any Registrable Shares for sale in any jurisdiction in the United States; 

(iv) furnish to the Investors and each managing underwriter, if any, without charge, conformed copies of each Registration
Statement and amendment thereto and copies of each supplement thereto promptly after they are filed with the SEC (but only one set of exhibits thereto need be provided); and deliver, without charge, such number of copies of the preliminary and final
Prospectus and any supplement thereto as the Investors may reasonably request in order to facilitate the disposition of the Registrable Shares of the applicable Investor covered by such Registration Statement in conformity with the requirements of
the Securities Act; 
 (v) use reasonable best efforts to register or qualify such Registrable Shares under such
other securities or blue sky laws of such U.S. jurisdictions as the applicable Investor reasonably requests and continue such registration or qualification in effect in such jurisdictions for as long as the applicable Registration Statement may be
required to be kept effective under this Agreement (provided that the Company will not be required to (I) qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify but for this
subparagraph (v), (II) subject itself to taxation in any such jurisdiction or (III) consent to general service of process in any such jurisdiction); 

(vi) notify the Investors and each distributor of such Registrable Shares identified by the applicable Investor, at any
time when a Prospectus relating thereto would be required under the Securities Act to be delivered by such distributor, of the occurrence of any event as a result of which the Prospectus included in such Registration Statement contains an untrue
statement of a material fact or omits a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, and, at the request of the Investors, the Company shall use reasonable best
efforts to prepare, as soon as practical, a supplement or amendment to such Prospectus so that, as thereafter delivered to any prospective purchasers of such Registrable Shares, such Prospectus shall not contain an untrue statement of a material
fact or omit to state any material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading; 

(vii) in the case of an underwritten offering in which the applicable Investor participates pursuant to a Demand
Registration, Piggyback Event or an S-3 Shelf Registration, enter into an underwriting agreement containing such provisions (including 

 

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provisions for indemnification, lockups, opinions of counsel and comfort letters) as are customary and reasonable for an offering of such kind, and take all such other customary and reasonable
actions as the managing underwriters of such offering may request in order to facilitate the disposition of such Registrable Shares (including making members of senior management of the Company available at reasonable times and places to participate
in “road-shows” and investor calls, provided that any reasonable travel and accommodation expenses in connection with any such road shows shall be borne by the applicable Investor(s)); provided, that if any Investor requests an
underwritten Investor Shelf Takedown in accordance with this Agreement, (i) no other Investor who is not participating in such underwritten Investor Shelf Takedown shall be required to enter into a lock-up agreement with the Company and/or
managing underwriter(s) and (ii) the Company shall not enter into any agreement in connection with such underwritten Investor Shelf Takedown that will limit the Company’s ability in any manner to conduct an underwritten Shelf Takedown at
the request of any other Investor at any time; 
 (viii) in the case of an underwritten offering in which the
applicable Investor participates pursuant to a Demand Registration, Piggyback Event or an S-3 Shelf Registration, and to the extent not prohibited by applicable law or pre-existing applicable contractual restrictions, (A) make reasonably
available, for inspection by the Investors, Investor’s Counsel, the managing underwriter(s) of such offering and counsel and accountants acting for such managing underwriter(s), pertinent corporate documents and financial and other records of
the Company and its subsidiaries and controlled Affiliates, (B) cause the Company’s officers and employees to supply information reasonably requested by the Investors or such managing underwriter(s) or attorney in connection with such
offering, (C) make the Company’s independent accountants available for any such managing underwriter(s)’ due diligence and have them provide customary “cold comfort” letters to such underwriters in connection therewith, and
(D) cause the Company’s counsel to furnish customary legal opinions to such underwriters in connection therewith; provided, however, that such records and other information shall be subject to such confidential treatment as
is customary for underwriters’ due diligence reviews; 
 (ix) use reasonable best efforts to cause all such
Registrable Shares to be listed on each securities exchange (if any) on which securities of the same class issued by the Company are then listed; 

(x) provide a transfer agent and registrar for all such Registrable Shares not later than the effective date of such
Registration Statement and, a reasonable time before any proposed sale of Registrable Shares pursuant to a Registration Statement, provide the transfer agent with printed certificates for the Registrable Shares to be sold, subject to the provisions
of Section 11; 
 (xi) make generally available to its shareholders a consolidated earnings statement (which
need not be audited) for a period of 12 months beginning after the effective date of the Registration Statement as soon as reasonably practicable after the end of such period, which earnings statement shall satisfy the requirements of an
earning statement under Section 11(a) of the Securities Act and Rule 158 thereunder; and 
  

 -11- 

 (xii) promptly notify the Investors and the managing underwriter(s) of any
underwritten offering, if any: 
 (1) when the Registration Statement, any pre-effective amendment, the
Prospectus or any Prospectus supplement or any post-effective amendment to the Registration Statement has been filed and, with respect to the Registration Statement or any post-effective amendment, when the same has become effective; 

(2) of any request by the SEC for amendments or supplements to the Registration Statement or the Prospectus or for any
additional information regarding the Investors; 
 (3) of the notification to the Company by the SEC of its
initiation of any proceeding with respect to the issuance by the SEC of any stop order suspending the effectiveness of the Registration Statement; and 

(4) of the receipt by the Company of any notification with respect to the suspension of the qualification of any
Registrable Shares for sale under the applicable securities or blue sky laws of any jurisdiction; and keep Investor’s Counsel reasonably apprised as to the intention and progress of the Company with respect to any Registration Statement
hereunder. 
 For the avoidance of doubt, the provisions of clauses (vii), (viii) and (xi) of this
Section 7(a) shall apply only in respect of an underwritten offering and only if (based on market prices at the time the offering is requested by the applicable Investor) the number of Registrable Shares to be sold in the offering would
reasonably be expected to yield gross proceeds to one or more Investors of at least the Minimum Amount. 
 (b) No Registration
Statement (including any amendments thereto) shall contain any untrue statement of a material fact or omit to state a material fact required to be stated therein, or necessary to make the statements therein not misleading, and no Prospectus
(including any supplements thereto) shall contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, in each
case, except for any untrue statement or alleged untrue statement of a material fact or omission or alleged omission of a material fact made in reliance on and in conformity with written information furnished to the Company by or on behalf of any
Investor or any underwriter or other distributor specifically for use therein. 
 (c) Until the applicable Termination Date, the
Company shall use reasonable best efforts to file all reports required to be filed by it under the Securities Act and the Exchange Act and the rules and regulations adopted by the SEC thereunder, all to the extent required to enable any Investor to
be eligible to sell Registrable Shares (if any) pursuant to Rule 144 under the Securities Act. 
 (d) The Company may
require any Investor and each distributor of Registrable Shares as to which any registration is being effected to furnish to the Company any other information regarding such Person and the distribution of such securities as the Company may from time
to time reasonably request. 
  

 -12- 

 (e) Subject to the limitations on the Company’s ability to delay the use or
effectiveness of a Registration Statement as provided by the Suspension Periods set forth in Section 5(a), each Investor agrees by having its stock treated as Registrable Shares hereunder that, upon being advised in writing by the Company of
the occurrence of an event pursuant to Section 6(a)(vi) when the Company is entitled to do so pursuant to Section 5, such Investor will immediately discontinue (and direct any other Persons making offers and sales of Registrable Shares to
immediately discontinue) offers and sales of Registrable Shares pursuant to any Registration Statement (other than those pursuant to a plan that is in effect and that complies with Rule 10b5-1 of the Exchange Act) until it is advised in writing by
the Company that the use of the Prospectus may be resumed and is furnished with a supplemented or amended Prospectus as contemplated by Section 6(a)(vi), and, if so directed by the Company, such Investor will deliver to the Company all copies,
other than permanent file copies then in such Investor’s possession, of the Prospectus covering such Registrable Shares current at the time of receipt of such notice. 

(f) The Company may prepare and deliver an issuer free-writing prospectus (as such term is defined in Rule 405 under the Securities
Act) in lieu of any supplement to a prospectus, and references herein to any “supplement” to a Prospectus shall include any such issuer free-writing prospectus. No seller of Registrable Shares may use a free-writing prospectus to offer or
sell any such shares without the Company’s prior written consent. 
 (g) It is understood and agreed that any failure of
the Company to file a registration statement or any amendment or supplement thereto or to cause any such document to become or remain effective or usable within or for any particular period of time as provided in Section 2, 4 or 6 or otherwise
in this Agreement, due to reasons that are not reasonably within its control, or due to any refusal of the SEC to permit a registration statement or prospectus to become or remain effective or to be used because of unresolved SEC comments thereon
(or on any documents incorporated therein by reference) despite the Company’s good faith and reasonable best efforts to resolve those comments, shall not be a breach of this Agreement. However, neither shall any such failure relieve the Company
of its obligations hereunder to continue to use reasonable best efforts to remedy such failure. 
 (h) It is further understood
and agreed that the Company shall not have any obligations under this Section 6 at any time on or after the applicable Termination Date, unless an underwritten offering in which an Investor participates has been priced but not completed prior
to the applicable Termination Date, in which event the Company’s obligations under this Section 6 shall continue with respect to such offering until it is so completed. 

Section 7. Registration Expenses. 

(a) All expenses incident to the Company’s performance of or compliance with this Agreement, including all registration and filing
fees, fees and expenses of compliance with securities or blue sky laws, Financial Industry Regulatory Authority fees, listing application fees, printing expenses, transfer agent’s and registrar’s fees, cost of distributing Prospectuses in
preliminary and final form as well as any supplements thereto, and fees and disbursements of counsel for the Company and all independent certified public accountants and other Persons retained by the Company, together with the reasonable documented
fees and expenses of one 
  

 -13- 

 
counsel for the Investor(s) (all such expenses being herein called “Registration Expenses”) (but not including any underwriting discounts or commissions attributable to the sale
of Registrable Shares), shall be borne by the Company. Each Investor shall bear its pro rata cost of all underwriting discounts and commissions associated with any sale of Registrable Shares. 

(b) The obligation of the Company to bear the expenses described in Section 7(a) shall apply irrespective of whether a registration,
once properly demanded or requested becomes effective or is withdrawn or suspended, unless the applicable Investor elects to pay the Registration Expenses, in which event such registration shall not count against the limit on the number of
registrations set forth in Section 2(b). 
 Section 8. Indemnification. 

(a) The Company shall indemnify, to the fullest extent permitted by law, the Investors and each Person who controls the Investors (within
the meaning of the Securities Act) against all losses, claims, damages, liabilities, judgments, costs (including reasonable costs of investigation) and expenses (including reasonable attorneys’ fees) arising out of or based upon any untrue or
alleged untrue statement of a material fact contained in any Registration Statement or Prospectus or any amendment thereof or supplement thereto or arising out of or based upon any omission or alleged omission of a material fact required to be
stated therein or necessary to make the statements therein not misleading, except insofar as the same are made in reliance and in conformity with information furnished in writing to the Company by the Investors or to the Company by any participating
underwriter, in each case expressly for use therein. In connection with an underwritten offering in which any Investor participates conducted pursuant to a registration effected hereunder, the Company shall indemnify each participating underwriter
and each Person who controls such underwriter (within the meaning of the Securities Act) to the same extent as provided above with respect to the indemnification of such Investor(s). 

(b) In connection with any Registration Statement in which an Investor is participating, such Investor shall furnish to the Company in
writing such information as the Company reasonably requests for use in connection with any such Registration Statement or Prospectus, or amendment or supplement thereto, and shall indemnify, severally and not jointly, to the fullest extent permitted
by law, the Company, its officers and directors and each Person who controls the Company (within the meaning of the Securities Act), against all losses, claims, damages, liabilities, judgments, costs (including reasonable costs of investigation) and
expenses (including reasonable attorneys’ fees) arising out of or based upon any untrue or alleged untrue statement of material fact contained in the Registration Statement or Prospectus, or any amendment or supplement thereto, or arising out
of or based upon any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein not misleading, but only to the extent that the same are made in reliance and in conformity with
information furnished in writing to the Company by or on behalf of such Investor expressly for use therein. In connection with an underwritten offering conducted pursuant to a registration effected hereunder, such Investor shall indemnify each
participating underwriter and each Person who controls such underwriter (within the meaning of the Securities Act) to the same extent as provided above with respect to the indemnification of the Company. 

 

 -14- 

 (c) Any Person entitled to indemnification hereunder shall (i) give prompt written
notice to the indemnifying Person of any claim with respect to which it seeks indemnification and (ii) permit such indemnifying Person to assume the defense of such claim with counsel reasonably satisfactory to the indemnified Person. Failure
so to notify the indemnifying Person shall not relieve it from any liability that it may have to an indemnified Person except to the extent that the indemnifying Person is materially and adversely prejudiced thereby. The indemnifying Person shall
not be subject to any liability for any settlement made by the indemnified Person without its consent (but such consent will not be unreasonably withheld). An indemnifying Person who is entitled to, and elects to, assume the defense of a claim shall
not be obligated to pay the fees and expenses of more than one counsel (in addition to one local counsel) for all Persons indemnified (hereunder or otherwise) by such indemnifying Person with respect to such claim (and all other claims arising out
of the same circumstances), unless in the reasonable judgment of any indemnified Person there may be one or more legal or equitable defenses available to such indemnified Person which are in addition to or may conflict with those available to
another indemnified Person with respect to such claim, in which case each such indemnified Person shall be entitled to use separate counsel. The indemnifying Person shall not consent to the entry of any judgment or enter into or agree to any
settlement relating to a claim or action for which any indemnified Person would be entitled to indemnification by any indemnified Person hereunder unless such judgment or settlement imposes no ongoing obligations on any such indemnified Person and
includes as an unconditional term the giving, by all relevant claimants and plaintiffs to such indemnified Person, a release, reasonably satisfactory in form and substance to such indemnified Person, from all liabilities in respect of such claim or
action for which such indemnified Person would be entitled to such indemnification. The indemnifying Person shall not be liable hereunder for any amount paid or payable or incurred pursuant to or in connection with any judgment entered or settlement
effected with the consent of an indemnified Person unless the indemnifying Person has also consented to such judgment or settlement. 

(d) The indemnification provided for under this Agreement shall remain in full force and effect regardless of any investigation made by
or on behalf of the indemnified Person or any officer, director or controlling Person of such indemnified Person and shall survive the transfer of securities and the applicable Termination Date but only with respect to offers and sales of
Registrable Shares made before the applicable Termination Date or during the period following the applicable Termination Date referred to in Section 6(h). 

(e) If the indemnification provided for in or pursuant to this Section 8 is due in accordance with the terms hereof, but is held by
a court to be unavailable or unenforceable in respect of any losses, claims, damages, liabilities or expenses referred to herein, then each applicable indemnifying Person, in lieu of indemnifying such indemnified Person, shall contribute to the
amount paid or payable by such indemnified Person as a result of such losses, claims, damages, liabilities or expenses in such proportion as is appropriate to reflect the relative fault of the indemnifying Person on the one hand and of the
indemnified Person on the other in connection with the statements or omissions which result in such losses, claims, damages, liabilities or expenses as well as any other relevant equitable considerations. The relative fault of the indemnifying
Person on the one hand and of the indemnified Person on the other shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact
relates to 
  

 -15- 

 
information supplied by the indemnifying Person or by the indemnified Person, and by such Person’s relative intent, knowledge, access to information and opportunity to correct or prevent
such statement or omission. In no event shall the liability of any Investor be greater in amount than the amount for which such indemnifying Person would have been obligated to pay by way of indemnification if the indemnification provided for under
Section 8(a) or 8(b) hereof had been available under the circumstances. 
 Section 9. Securities Act
Restrictions. 
 (a) Each Investor agrees that all certificates or other instruments representing the Merger Securities will
bear a legend substantially to the following effect: 
 (1) THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR SECURITIES LAWS OF ANY STATE AND MAY NOT BE TRANSFERRED, SOLD OR OTHERWISE DISPOSED OF EXCEPT WHILE A REGISTRATION STATEMENT RELATING THERETO IS IN EFFECT UNDER SUCH ACT AND APPLICABLE
STATE SECURITIES LAWS OR PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT OR SUCH LAWS. 
 (2) THE SECURITIES
REPRESENTED BY THIS CERTIFICATE MAY BE TRANSFERRED ONLY IN ACCORANCE WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND THE INVESTOR, COPIES OF WHICH ARE ON FILE WITH THE SECRETARY OF THE COMPANY. 

(b) Upon the reasonable request of an Investor, at a time when such legend is no longer required under the Securities Act and applicable
state laws, the Company shall promptly cause clause (1) of the legend to be removed from any certificate for any Merger Securities to be Transferred by such Investor in accordance with the terms of the relevant Lock-up Agreement upon the
receipt by the Company of an opinion of counsel, certification and/or other information reasonably satisfactory to the Company; and clause (2) of the legend shall be removed upon the expiration of such transfer and other restrictions set forth
in the relevant Lock-up Agreement. Each Investor acknowledges that the Merger Securities have not been registered under the Securities Act or under any state securities laws and agrees that it will not sell or otherwise dispose of any of the Merger
Securities, except in compliance with the registration requirements or exemption provisions of the Securities Act and any other applicable securities laws. 

Section 10. Transfers of Rights. 

(a) If an Investor transfers Registrable Shares it owns to a third party, such party shall succeed to the rights and obligations of such
Investor under this Agreement with respect to such Registrable Shares and be treated hereunder as if it were a separate “Investor” hereunder. Such party shall deliver to the Company a written acknowledgment (in form and substance
reasonably satisfactory to the Company) that it has succeeded to such Investor as a party to this Agreement and has assumed the rights and obligations of such Investor hereunder (the “Transferee’). The Transferee shall automatically
become and have the rights and obligations of an Investor with respect to the Registrable Shares so transferred and the transferor shall automatically cease to be 

 

 -16- 

 
and to have the rights and obligations of an Investor but only with respect to the transferred Registrable Shares and the transferor shall otherwise maintain all of its rights and obligations as
a separate Investor hereunder, provided that the rights and obligations of the transferor arising under Section 8 or otherwise hereunder with respect to periods and matters existing before such cessation shall survive such cessation.
Notwithstanding any other provision of this Agreement, no Person who acquires securities transferred in violation of this Agreement or the Lock-up Agreement or who acquires securities that are not or upon acquisition cease to be Registrable Shares,
shall have any rights under this Agreement with respect to such securities, and such securities shall not have the benefits afforded hereunder to Registrable Shares. 

Section 11. Miscellaneous. 

(a) Notices. Except as otherwise provided herein, all notices, requests, consents and other communications required or permitted
hereunder shall be in writing and shall be hand delivered, mailed (postage prepaid) by registered or certified mail or sent by e-mail or facsimile transmission (with telephone confirmation promptly thereafter), 

 

					
	If to Investor:
		
		  	See Schedule I for Investor Address Information
	  
 With a copy to:

		
		  	Edwards Angell Palmer & Dodge LLP
		  	111 Huntington Avenue
		  	Boston, MA 02199-7613
		  	Attention:	  	James T. Barrett, Esq.
		  		  	Matthew J. Gardella, Esq.
		  	Telecopy: 617-227-4420
	  
 If to the Company:

		
		  	 MDRNA, Inc.

3830 Monte Villa Parkway
 Bothell, WA
98021
 Attention: J. Michael French, President and CEO

Telecopy: 425-908-3650

	  
 With a copy to:

		
		  	 Pryor Cashman LLP

7 Times Square
 New York, NY 10036

Attention: Lawrence Remmel, Esq.
 Telecopy:
(212) 798-6365

  

 -17- 

 or at such other address as any such party hereto may specify by written notice to the others, and, except
as otherwise provided herein, each such notice, request, consent and other communication shall for all purposes of the Agreement be treated as being effective or having been given when delivered personally or by mail or, in the case of e-mail or
facsimile delivery, upon receipt of e-mail or facsimile confirmation of delivery and telephonic confirmation. 
 (b) No
Waivers. No failure or delay by any party in exercising any right, power or privilege hereunder shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of
any other right, power or privilege. The rights and remedies herein provided shall be cumulative and not exclusive of any rights or remedies provided by law. 

(c) Successors and Assigns. The provisions of this Agreement shall be binding upon and inure to the benefit of the parties hereto
and their respective successors and Transferees, it being understood that there are no intended third-party beneficiaries hereof (except as specified in Section 10 hereof). 

(d) Governing Law. This Agreement shall be governed by and construed in accordance with the General Corporation Law of the State
of Delaware as to matters within the scope thereof, and as to all other matters, shall be governed by and construed in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to conflict of law principles that would
result in the application of any law other than the law of the Commonwealth of Massachusetts. 
 (e) Jurisdiction. Any
suit, action or proceeding seeking to enforce any provision of, or based on any matter arising out of or in connection with, this Agreement or the transactions contemplated hereby must be brought in any federal or state court located in the
non-exclusive jurisdiction of any Delaware State or Federal court sitting in New Castle County, and each of the parties hereby consents to the jurisdiction of such courts (and of the appropriate appellate courts therefrom) in any such suit, action
or proceeding and irrevocably waives, to the fullest extent permitted by law, any objection which it may now or hereafter have to the laying of the venue of any such suit, action or proceeding in any such court or that any such suit, action or
proceeding which is brought in any such court has been brought in an inconvenient forum. Process in any such suit, action or proceeding may be served on any party anywhere in the world, whether within or without the jurisdiction of any such court.
Without limiting the foregoing, each party agrees that service of process on such party as provided in Section 13(a) shall be deemed effective service of process on such party. 

(f) Waiver of Jury Trial. EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL
PROCEEDING ARISING OUT OF OR RELATED TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 
 (g) Counterparts;
Effectiveness. This Agreement may be executed in any number of counterparts (including by e-mail or facsimile) and by different parties hereto in separate counterparts, with the same effect as if all parties had signed the same document. All
such counterparts shall be deemed an original, shall be construed together and shall constitute one and the same instrument. This Agreement shall become effective when each party hereto shall have received counterparts hereof signed by all of the
other parties hereto. 
  

 -18- 

 (h) Entire Agreement. This Agreement, as modified by a certain Letter Agreement dated
July 21, 2010 delivered by Biomedical Value Fund, L.P., Biomedical Institutional Value Fund, L.P., Biomedical Offshore Value Fund, Ltd., Class D Series of GEF-PS, L.P., Lyrical Multi-Manager Fund, L.P., David J. Morrison, and WS Investments
III, LLC (the “New Investors”) and among the Company, the New Investors and certain of the Investors, contains the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes and replaces all
other prior agreements, written or oral, among the parties hereto with respect to the subject matter hereof. 
 (i)
Captions. The headings and other captions in this Agreement are for convenience and reference only and shall not be used in interpreting, construing or enforcing any provision of this Agreement. 

(j) Severability. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction
or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect and shall in no way be affected, impaired or invalidated so long as
the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such a determination, the parties shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties as closely as possible in an acceptable manner in order that the transactions contemplated hereby be consummated as originally contemplated to the fullest extent possible. 

(k) Amendments. (a) The provisions of this Agreement, including the provisions of this sentence, may not be amended, modified
or supplemented, and waivers or consents to departures from the provisions hereof may not be given without the prior written consent of the Company and the Investors. 

(b) The Company has not entered into, and will not, from and after the date hereof, enter into, any agreements or arrangements that grant
to any other holders of its securities any rights that violate or conflict with this Agreement or impede the Company’s ability to fulfill and comply with its obligations set forth herein. 

(l) Lock-Up. Each Investor shall, in connection with any underwritten offering of the Company’s securities, in each case, in
which such Investor is selling Registrable Shares pursuant to its rights under Section 3, upon the request of the Company or the managing underwriter(s), agree in writing not to effect any sale, disposition or distribution of any Registrable
Shares (other than those included in such offering) without the prior written consent of the Company or such managing underwriter(s), as the case may be, for such period of time prior to and/or following the completion of the sale of the
Company’s securities in such underwritten offering as the Company or the managing underwriter(s) may specify; provided, however, that all executive officers and directors of the Company shall also have agreed not to effect any sale, disposition
or distribution of any such securities under the circumstances and pursuant to the terms set forth in this Section 11(l). 
  

 -19- 

 (m) Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company shall not, without the prior written consent of the Investors of a majority of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any securities of the Company that
would allow such holder or prospective holder (i) to include such securities in any registration unless, under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only to the
extent that the inclusion of such securities will not reduce the number of the Registrable Securities of the Investors that are included or (ii) to have registration rights that are more favorable in the aggregate than those set forth herein;
provided that this limitation shall not apply to any additional Investor who becomes a party to this Agreement in accordance with Section 10. 

[Execution Page Follows] 
  

 -20- 

 IN WITNESS WHEREOF, this Registration Rights Agreement has been duly executed by each of the
parties hereto as of the date first written above. 
  

					
	COMPANY:
	
	MDRNA, INC.
		
	By:	 	 /s/ J. Michael French

	Name:	 	J. Michael French
	Title:	 	President and CEO
	
	INVESTORS:
	
	A.M. PAPPAS LIFE SCIENCE VENTURES III, LP
		
	By:	 	 /s/ Ford S. Worthy

	Name:	 	Ford S. Worthy
	Title:	 	Partner
	
	PVIII CEO FUND, LP
		
	By:	 	 /s/ Ford S. Worthy

	Name:	 	Ford S. Worthy
	Title:	 	Partner
	
	 AMPERSAND 2006 LIMITED PARTNERSHIP

	
	 By: AMP-06 Management Company Limited

Partnership, its General Partner

		
	By:	 	AMP-06 MC LLC, its General Partner
		
	By:	 	 /s/ Herbert H. Hooper

	Name:	 	Herbert H. Hooper
	Title:	 	Member
	
	NOVARTIS BIOVENTURES LTD.
		
	By:	 	 /s/ Wendy Wiseman

	Name:	 	Wendy Wiseman
	Title:	 	Authorized Signatory

			
	YED GLOBAL LIFESCIENCE I PARTNERSHIP
		
	 By:
	 	 /s/ Tsuneo Fujii

	 Name:
	 	 Tsuneo Fujii

	 Title:
	 	 President and Representative Director

	
	 YED IV, L.P.

		
	 By:
	 	 /s/ Tsuneo Fujii

	 Name:
	 	 Tsuneo Fujii

	 Title:
	 	 President and Representative Director

			
	GOLD HILL VENTURE LENDING 03, L.P.
	
	By: Gold Hill Venture Lending Partners 03, LLC, its general partner
		
	By:	 	 /s/ Rob Helm

	Name:	 	Rob Helm
	Title:	 	Managing Director
	
	PETER D. PARKER
	
	 /s/ Peter D. Parker

	Name: Peter D. Parker
	
	CHIANG LI
	
	 /s/ Chiang Li

	Name: Chiang Li

									
	 BIOMEDICAL VALUE FUND, L.P.
	 		 	 BIOMEDICAL OFFSHORE VALUE FUND, LTD.

			
	 By: Great Point Partners, LLC, as Investment Manager
	 		 	 By: Great Point Partners, LLC, as Investment Manager

					
	By:	 	 /s/ Jeffrey R. Jay
	 		 	By:	 	 /s/ Jeffrey R. Jay

	Name:	 	 Jeffrey R. Jay
	 		 	Name:	 	 Jeffrey R. Jay

	Title:	 	 Senior Managing Member
	 		 	Title:	 	 Senior Managing Member

			
	BIOMEDICAL INSTITUTIONAL VALUE FUND, L.P.	 		 	 CLASS D SERIES OF GEF-PS, L.P.

			
	 By: Great Point Partners, LLC, as Investment Manager
	 		 	 By: Great Point Partners, LLC, as Investment Manager

					
	By:	 	 /s/ Jeffrey R. Jay
	 		 	By:	 	 /s/ Jeffrey R. Jay

	Name:	 	 Jeffrey R. Jay
	 		 	Name:	 	 Jeffrey R. Jay

	Title:	 	 Senior Managing Member
	 		 	Title:	 	 Senior Managing Member

			
	 LYRICAL MULTI-MANAGER FUND, L.P.
	 		 	 WS INVESTMENTS III, LLC

			
	 By: Great Point Partners, LLC, as Investment Manager
	 		 	 By: Great Point Partners, LLC, as Investment Manager

					
	By:	 	 /s/ Jeffrey R. Jay
	 		 	By:	 	 /s/ Jeffrey R. Jay

	Name:	 	 Jeffrey R. Jay
	 		 	Name:	 	 Jeffrey R. Jay

	Title:	 	 Senior Managing Member
	 		 	Title:	 	 Senior Managing Member

				
	 DAVID J. MORRISON
	 		 		 	
				
	 By: Great Point Partners, LLC, as Investment Manager
	 		 		 	
					
	By:	 	 /s/ Jeffrey R. Jay
	 		 		 	
	Name:	 	 Jeffrey R. Jay
	 		 		 	
	Title:	 	 Senior Managing Member
	 		 		 	

			
	EMERGE CAPITAL
		
	By:	 	 /s/ Michel de Beaumont

	Name:	 	Mr. Michel de Beaumont
	Title:	 	Chairman

 [Registration Rights Agreement
Signature Page] 

 Schedule I 

INVESTORS 
 A.M.
PAPPAS LIFE SCIENCE VENTURES III, LP 
 PVIII CEO FUND, LP 

AMPERSAND 2006 LIMITED PARTNERSHIP 
 NOVARTIS
BIOVENTURES LTD. 
 YED GLOBAL LIFESCIENCE I PARTNERSHIP 

YED IV, L.P. 
 GOLD HILL VENTURE LENDING 03, L.P.

 BIOMEDICAL VALUE FUND, L.P. 

BIOMEDICAL OFFSHORE VALUE FUND, LTD. 
 BIOMEDICAL
INSTITUTIONAL VALUE FUND, L.P. 
 CLASS D SERIES OF GEF-PS, L.P. 

LYRICAL MULTI-MANAGER FUND, L.P. 
 WS INVESTMENTS
III, LLC 
 DAVID J. MORRISON 
 EMERGE
CAPITAL 
 PETER D. PARKER 
 CHIANG LI

 ESTATE OF SAMUEL ACKERMAN 
 THOMAS
LAMONT 
 ANTHONY BALDOR 
 BETH ISRAEL
DEACONNESS MEDICAL CENTER 
 AMY PARKER 

ANDREW PARKER 

 Annex A 

PLAN OF DISTRIBUTION 

Each selling stockholder, and any of their pledgees, assignees and successors-in-interest (the “Selling Stockholders”) may from
time to time offer and sell, separately or together, some or all of the shares of Common Stock covered by this registration statement. Registration of shares of common stock covered by the registration statement does not mean, however, that those
shares necessarily will be offered or sold. 
 The Company will not receive any proceeds from the sale of the common shares by
the Selling Stockholders. 
 The Selling Stockholder may sell shares in one or more of the following ways (or in any
combination) from time to time: 
  

	 	•	 	 through underwriters or dealers; 

  

	 	•	 	 directly to one or more purchasers; 

  

	 	•	 	 through agents; or 

  

	 	•	 	 through any other methods described in a prospectus supplement. 

Neither the Company nor the Selling Stockholders have entered into any agreements, understandings or arrangements with any underwriters
or dealers regarding the sale of shares covered by the registration statement. At any time a particular offer of the shares covered by the registration statement is made, a revised prospectus or prospectus supplement, if required, will be
distributed which will set forth the aggregate amount of shares of common stock covered by the registration statement being offered and the terms of the offering, including the name or names of any underwriters, dealers or agents. In addition, to
the extent required, any discounts, commissions, concessions and other items constituting underwriters’ or agents’ compensation, as well as any discounts, commissions or concessions allowed or re-allowed or paid to dealers, will be set
forth in such revised prospectus or prospectus supplement. Any such required prospectus or prospectus supplement, and, if necessary, a post-effective amendment to any registration statement, will be filed with the SEC to reflect the disclosure of
additional information with respect to the distribution of the Common Shares covered by the registration statement. 
 The
shares may also be sold in one or more of the following transactions, or in any transactions described in a prospectus or prospectus supplement: 
  

	 	•	 	 block transactions in which a broker-dealer may sell all or a portion of the shares as agent but may position and resell all or a portion of the block
as principal to facilitate the transaction; 

  

	 	•	 	 purchase by a broker-dealer as principal and resale by the broker-dealer for its own account; 

 

 A-1 

	 	•	 	 ordinary brokerage transactions and transactions in which a broker-dealer solicits purchasers; 

 

	 	•	 	 sales “at the market” to or through a market maker or into an existing trading market, on an exchange or otherwise;

  

	 	•	 	 through the writing of options; or 

  

	 	•	 	 sales in other ways not involving market makers or established trading markets, including direct sales to purchasers. 

The shares that the Selling Stockholder sell by any of the methods described above may be sold to the public, in one or more
transactions, either: 
  

	 	•	 	 at a fixed public offering price or prices, which may be changed; 

 

	 	•	 	 at market prices prevailing at the time of sale; 

  

	 	•	 	 at prices related to prevailing market prices; 

  

	 	•	 	 at varied prices determined at the time of sale; or 

  

	 	•	 	 at negotiated prices. 

Underwriters and agents may be entitled under agreements entered into with the Selling Stockholders to indemnification by the Company
and/or the Selling Stockholders against certain civil liabilities, including liabilities under the Securities Act, or to contribution with respect to payments which the underwriters or agents may be required to make. Underwriters and agents may
engage in transactions with, or perform services for, the Company, the Company’s affiliates, the Selling Stockholders and their affiliates in the ordinary course of business. 

The Selling Stockholders may also sell shares under Rule 144 under the Securities Act of 1933, as amended (the “Securities
Act”), if available. 
 Broker-dealers engaged by the Selling Stockholders may arrange for other brokers-dealers to
participate in sales. Broker-dealers may receive commissions or discounts from the Selling Stockholders (or, if any broker-dealer acts as agent for the purchaser of shares, from the purchaser) in amounts to be negotiated, but, except as set forth in
a supplement to this Prospectus, in the case of an agency transaction not in excess of a customary brokerage commission in compliance with FINRA Rule 2440; and in the case of a principal transaction a markup or markdown in compliance with FINRA
IM-2440. 
 In connection with the sale of the common stock or interests therein, the Selling Stockholders may enter into
hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the common stock in the course of hedging the positions they assume. The Selling Stockholders may also sell shares of the common
stock short and deliver these securities to close out their short positions, or loan or pledge the common stock to broker-dealers that in turn may sell these securities. The Selling Stockholders

  

 A-2 

 
may also enter into option or other transactions with broker-dealers or other financial institutions or the creation of one or more derivative securities which require the delivery to such
broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

 The Selling Stockholders and any broker-dealers or agents that are involved in selling the shares may be deemed to be
“underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the shares purchased by them may be deemed to
be underwriting commissions or discounts under the Securities Act. Each Selling Stockholder has informed the Company that it does not have any written or oral agreement or understanding, directly or indirectly, with any person to distribute the
Common Stock. In no event shall any broker-dealer receive fees, commissions and markups which, in the aggregate, would exceed eight percent (8%). 

The Company is required to pay certain fees and expenses incurred by the Company incident to the registration of the shares. The Company
has agreed to indemnify the Selling Stockholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act. 

Because Selling Stockholders may be deemed to be “underwriters” within the meaning of the Securities Act, they will be subject
to the prospectus delivery requirements of the Securities Act including Rule 172 thereunder. There is no underwriter or coordinating broker acting in connection with the proposed sale of the resale shares by the Selling Stockholders. 

The Company has agreed to keep this prospectus effective until the earlier of (i) the date on which the shares may be resold by the
Selling Stockholders without registration by reason of Rule 144 under the Securities Act or any other rule of similar effect or (ii) all of the shares have been sold pursuant to this prospectus or Rule 144 under the Securities Act or any other
rule of similar effect. The resale shares will be sold only through registered or licensed brokers or dealers if required under applicable state securities laws. In addition, in certain states, the resale shares may not be sold unless they have been
registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with. 

Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale shares may not
simultaneously engage in market making activities with respect to the common stock for the applicable restricted period, as defined in Regulation M, prior to the commencement of the distribution. In addition, the Selling Stockholders will be subject
to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of shares of the common stock by the Selling Stockholders or any other person. The
Company will make copies of this prospectus available to the Selling Stockholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale (including by compliance with Rule 172
under the Securities Act). 
 * * * 
  

 A-3 

 Annex B 

MDRNA, INC. 

Selling Securityholder Notice and Questionnaire 

The undersigned beneficial owner of common stock (the “Registrable Securities”) of MDRNA, Inc., a Delaware corporation
(the “Company”), understands that the Company has filed or intends to file with the Securities and Exchange Commission (the “SEC”) a registration statement (the “Registration Statement”) for the
registration and resale under Rule 415 of the Securities Act of 1933, as amended (the “Securities Act”), of the Registrable Securities, in accordance with the terms of the Registration Rights Agreement (the “Registration
Rights Agreement”) to which this document is annexed. A copy of the Registration Rights Agreement is available from the Company upon request at the address set forth below. All capitalized terms not otherwise defined herein shall have the
meanings ascribed thereto in the Registration Rights Agreement. 
 Certain legal consequences arise from being named as a
selling securityholder in the Registration Statement and the related prospectus. Accordingly, holders and beneficial owners of Registrable Securities are advised to consult their own securities law counsel regarding the consequences of being named
or not being named as a selling securityholder in the Registration Statement and the related prospectus. 
 NOTICE 

The undersigned beneficial owner (the “Selling Securityholder”) of Registrable Securities hereby elects to include the
Registrable Securities owned by it in the Registration Statement. 
 The undersigned hereby provides the following information
to the Company and represents and warrants that such information is accurate: 
 QUESTIONNAIRE 

 

	1.	Name. 

 (a) Full Legal Name of
Selling Securityholder 
  

			
		 	  

(b) Full Legal Name of Registered Holder (if not the same as (a) above) through which Registrable Securities are held: 

 

			
		 	  

 

 B-1 

 (c) Full Legal Name of Natural Control Person (which means a natural person who directly or
indirectly alone or with others has power to vote or dispose of the securities covered by the Questionnaire): 
  

			
		 	  

 

	2.	Address for Notices to Selling Securityholder: 

  

 
  

 
  

 

			
	Telephone:	 	  

			
	Fax:	 	  

			
	Contact Person:	 	  

 

	3.	Broker-Dealer Status: 

 (a) Are
you a broker-dealer? 

Yes   ̈            
No   ̈ 
 (b) If “yes” to Section 3(a), did you receive
your Registrable Securities as compensation for investment banking services to the Company. 

Yes   ̈            
No   ̈ 
  

	 	Note:	If “no” to Section 3(b), the SEC’s staff has indicated that you should be identified as an underwriter in the Registration Statement.

 (c) Are you an affiliate of a broker-dealer? 

Yes   ̈            
No   ̈ 
 (d) If you are an affiliate of a broker-dealer, do you certify
that you purchased the Registrable Securities in the ordinary course of business, and at the time of the purchase of the Registrable Securities to be resold, you had no agreements or understandings, directly or indirectly, with any person to
distribute the Registrable Securities? 

Yes   ̈            
No   ̈ 
  

	 	Note:	If “no” to Section 3(d), the SEC’s staff has indicated that you should be identified as an underwriter in the Registration Statement.

  

 B-2 

	4.	Beneficial Ownership of Securities of the Company Owned by the Selling Securityholder. 

Except as set forth below in this Item 4, the undersigned is not the beneficial or registered owner of any securities of the
Company other than the securities issuable pursuant to the Purchase Agreement. 
 (a) Type and Amount of other securities
beneficially owned by the Selling Securityholder: 
  

			
		 	  

		 	  

 

	5.	Relationships with the Company: 

Except as set forth below, neither the undersigned nor any of its affiliates, officers, directors or principal equity holders (owners
of 5% of more of the equity securities of the undersigned) has held any position or office or has had any other material relationship with the Company (or its predecessors or affiliates) during the past three years. 

State any exceptions here: 
  

			
		 	  

		 	  

The undersigned agrees to promptly notify the Company of any inaccuracies or changes in the information provided herein that may occur
subsequent to the date hereof at any time while the Registration Statement remains effective. 
 By signing below, the
undersigned consents to the disclosure of the information contained herein in its answers to Items 1 through 5 and the inclusion of such information in the Registration Statement and the related prospectus and any amendments or supplements thereto.
The undersigned understands that such information will be relied upon by the Company in connection with the preparation or amendment of the Registration Statement and the related prospectus. 

 

 B-3 

 IN WITNESS WHEREOF the undersigned, by authority duly given, has caused this Notice and
Questionnaire to be executed and delivered either in person or by its duly authorized agent. 
  

									
	Dated:	 	  
	 		 	Beneficial Owner:
					
		 		 		 	By:	 	  

		 		 		 		 	Name:
		 		 		 		 	Title:

 PLEASE FAX A COPY OF THE COMPLETED AND EXECUTED
NOTICE AND QUESTIONNAIRE, AND RETURN THE ORIGINAL BY OVERNIGHT MAIL, TO: 
  

 B-4Stockholders Agreement

 Exhibit 10.2 

Execution Copy 

STOCKHOLDERS’ AGREEMENT 

This Stockholders’ Agreement (this “Agreement”), dated as of July 21, 2010, is made by and among MDRNA, Inc.,
a Delaware corporation (the “Company”) and the holders identified on Annex I (together with their respective successors and assigns, the “Holders”; the Holders are each individually referred to herein as a
“Holder”). 
 WHEREAS, The Company, Calais Acquisition Corp., a Delaware corporation and a wholly-owned
subsidiary of the Company (“Merger Sub”), and Cequent Pharmaceuticals, Inc. (“Cequent”), a Delaware corporation, entered into an Agreement and Plan of Merger, dated March 31, 2010 (the “Merger
Agreement”) pursuant to which Merger Sub will merge with and into Cequent, and Cequent will be the surviving entity (the “Merger”). 

WHEREAS, Upon the Effective Time and thereafter, Section 2.04 of the Merger Agreement contemplates certain director
nomination rights with respect to the Purchaser Board. 
 NOW, THEREFORE, in consideration of the mutual promises,
representations, warranties and covenants herein contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the Holders mutually agree as follows. Capitalized terms used
and not otherwise defined herein shall have the meanings given such terms in the Merger Agreement. 
 ARTICLE 1

 BOARD OF DIRECTORS 

1.1 Board of Directors and Committee Designation Rights; Voting Agreement. 

(a) During the period beginning at the Effective Time and ending immediately prior to the 2011 Annual Meeting of the Stockholders of the
Company (the “2011 Annual Meeting”), the Company shall maintain a Board of Directors (the “Board”) consisting of no more than seven (7) individuals, and each committee of the Board (including, without
limitation, the Audit Committee, the Compensation Committee, and the Nominating and Corporate Governance Committee (the “Nominating Committee”), or other committees serving similar functions) shall be comprised of four
(4) directors. The directors serving on each committee of the Board shall be selected in good faith by the Nominating Committee, and in the selection of the members of each committee the Nominating Committee shall ensure that the composition of
each committee shall be in accordance with the rules, regulations and requirements of The NASDAQ Stock Market. 
 (b) Each of
(i) Ampersand 2006 Limited Partnership, (ii) A.M. Pappas Life Science Ventures III, LP and PVIII CEO Fund, LP, and (iii) Novartis BioVentures Ltd. (each a “Designator”) shall have the right to submit to the Nominating
Committee for consideration as a director the name of a director nominee (each such person a “Director Nominee”), and if the Nominating Committee deems, in the exercise of its reasonable good faith discretion, the Director Nominee
qualified, the Nominating Committee shall appoint the Director Nominee to serve as a director (upon such appointment, a “Designated Director”) of the Company until the 

 
2011 Annual Meeting. The Company shall fill any vacancies that may arise upon the resignation, removal, death or disability of any Designated Director with a new Designated Director designated in
accordance with the foregoing Section 1.1, provided that the Designator who designated such Designated Director continues to own at least twenty-five percent (25%) of the Purchaser Common Stock issued to it as Merger Consideration in the
Merger. The initial Director Nominees shall be Peter D. Parker, Michael D. Taylor and Chiang Li. All subsidiaries of the Company shall maintain a Board of Directors whose composition is identical to that of the Board. 

(c) The Company shall provide at least thirty (30) days’ prior written notice of all intended mailings of notices to the
Holders for a meeting at which directors are to be elected (or an action by written consent pursuant to which directors are to be elected) to each Designator, and each Designator shall notify the Company in writing, at least ten (10) days prior
to such mailing, of the person(s) so designated as nominees for election as directors in accordance with Section 1.1. If any Designator shall fail to give notice to the Company as provided above, the Nominating Committee shall have the right to
nominate any other person to fill such directorship in its reasonable judgment and in the exercise of good faith. 
 (d) Each
Holder agrees to vote all of his, her or its Voting Securities from time to time and at all times in whatever manner as shall be necessary to ensure that (i) no director elected pursuant to Section 1.1 of this Agreement may be removed from
office other than for cause unless (A) such removal is directed or approved by the Designator entitled under Section 1.1 to designate that director or (B) the Designator originally entitled to designate such director pursuant to
Section 1.1 is no longer so entitled to designate such director; and (ii) any vacancies created by the resignation, removal, death or disability of a Designated Director shall be filled pursuant to the provisions of Section 1.1. All
Holders agree to execute any written consents required to effectuate the obligations of this Agreement. 
 (e) The Company shall
take such action as is necessary to convene meetings of the Nominating Committee, of the Board and, if applicable, meetings of the Holders for the appointment and election of the directors (or to act by written consent) in order to elect the
Designated Directors in accordance with Section 1.1. 
 (f) The Company hereby represents and warrants that as of the date
hereof the transactions contemplated hereby are not inconsistent with the Company’s Certificate of Incorporation or By-laws and agrees that until such time as the obligations under this Section 1.1 have expired, the Company will not take
any action or amend its Certificate of Incorporation or By-laws in a manner inconsistent with or in derogation of this Agreement. 

(g) Each Holder hereby grants to the Secretary of the Company, in the event that such Holder fails to vote its Voting Securities as
required by this Agreement, a proxy coupled with an interest in all Voting Securities beneficially owned by such Holder to vote such Voting Securities in accordance with this Section 1.1, which proxy is irrevocable until this Agreement
terminates pursuant to its terms or is amended to remove such grant of proxy in accordance with Section 1.1 of this Agreement. 
  

 2 

 ARTICLE 2 

MISCELLANEOUS 

2.1 Expenses. Except as otherwise provided herein, each of the parties hereto will pay its own expenses incurred by or on its
behalf in connection with this Agreement or any transaction contemplated by this Agreement, whether or not such transaction shall be consummated, including without limitation all fees of its respective legal counsel and accountants 

2.2 Notices. (a) All notices, requests, demands, consents or waivers and other communications required or permitted hereunder
shall be in writing and shall be deemed to have been duly given if delivered by hand or by telecopy (with immediate confirmation), one business day after being sent if by nationally recognized overnight courier or if mailed, then four days after
being sent by certified or registered mail, return receipt requested with postage prepaid: 
 If to the Holders, to the address
set forth on the stock records books of the Company. 
 If to the Designators: 

Ampersand 2006 Limited Partnership: 

Ampersand Ventures 

55 William St., Ste. 240 

Wellesley, MA 02481 

Attention: Herbert Hooper 

Telecopy: 781-239-0824 

A.M. Pappas Life Science Ventures III LP and PVIII CEO Fund, LP: 

Pappas Ventures 

2520 Meridian Parkway, Suite 400 

Durham, NC 27713 

Attention: Eric W. Linsley 

Telecopy: 919-998-3301 

Novartis Bioventures Ltd.: 

Novartis Bioventures Ltd. 

Five Cambridge Center, 

Cambridge, MA 02142 

Attention: Lauren Silverman 

Telecopy: 617-871-3536 
  

 3 

 With a copy to: 

Edwards Angel Palmer & Dodge LLP 

111 Huntington Avenue 

Boston, MA 02199-7613 

Attention: James T. Barrett, Esq. 

                 Matthew J. Gardella, Esq.

 Telecopy: 617-227-4420 

If to the Company: 

MDRNA, Inc. 

3830 Monte Villa Parkway 

Bothell, WA 98021 

Attention: J. Michael French, President and CEO 

Telecopy: 425-908-3650 

With a copy to: 

Pryor Cashman LLP 

7 Times Square 

New York, NY 10036 

Attention: Lawrence Remmel, Esq. 

Telecopy: 212-798-6365 
 or, in
each case, to such other person or address as any party shall furnish to the other parties in writing. 
 2.3 Binding; No
Assignment. This Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties hereto and their respective successors and permitted assigns, but neither this Agreement nor any of the rights, interests
or obligations hereunder shall be assigned by any of the parties hereto without the prior written consent of the other parties, except by operation of Law and except that the Company may assign all or part of this Agreement and its rights hereunder
(a) to an Affiliate of the Company or (b) from and after the Closing to a person, not a party to this Agreement, who acquires substantially all of the assets of the Company and who assumes all of the obligations of the Company hereunder,
provided in each such case that no such assignment shall release the Company from its duties and obligations hereunder. 
 2.4
Severability. If in any jurisdiction, any provision of this Agreement or its application to any party or circumstance is restricted, prohibited or unenforceable, such provision shall, as to such jurisdiction, be ineffective only to the extent
of such restriction, prohibition or unenforceability without invalidating the remaining provisions hereof and without affecting the validity or enforceability of such provision in any other jurisdiction or its application to other parties or
circumstances. In addition, if any one or more of the provisions contained in this Agreement shall for any reason in any jurisdiction be held to be excessively broad as to time, duration, geographical scope, activity or subject, it shall be
construed by limiting and reducing it, so as to be enforceable to the extent compatible with the applicable Law of such jurisdiction as it shall then appear. 
  

 4 

 2.5 Governing Law; Consent to Jurisdiction and Venue. The parties acknowledge and
agree that this Agreement shall be governed by the Laws of the State of Delaware as to all matters including, but not limited to, matters of validity, construction, effect, performance and liability, without consideration of conflicts of laws
provisions contained therein and that the courts of the State of Delaware shall have exclusive jurisdiction of all disputes with respect to this Agreement, including without limitation, any dispute relating to the construction or interpretation of
the rights and obligations of any party, which is not resolved through discussion between the parties. 
 Each party hereto hereby irrevocably
and unconditionally submits to the non-exclusive jurisdiction of any Delaware State or Federal court sitting in New Castle County in any action or proceeding arising out of or relating to this Agreement, or any transaction contemplated hereby. The
Company and the Holders hereby irrevocably waive, to the fullest extent they may effectively do so, the defense of an inconvenient forum to the maintenance of such action or proceeding, and also irrevocably and unconditionally consent to the service
of any and all process in any such action or proceeding by the mailing of copies of such process by certified mail to their respective addresses specified in Section 2.2. The Company and the Holders further irrevocably and unconditionally agree
that a final judgment in any such action or proceeding (after exhaustion of all appeals or expiration of the time for appeal) shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by
Law. 
 2.6 Counterparts. This Agreement may be executed simultaneously in two or more counterparts, each of which shall
be deemed an original, but all of which together shall constitute one and the same instrument. 
 2.7 Headings. The title
of this Agreement and the headings of the Sections and Articles of this Agreement are for reference purposes only and shall not be used in construing or interpreting this Agreement. 

2.8 Entire Agreement; Amendment; Waiver. This Agreement and any documents delivered pursuant to the terms hereof, set forth the
entire agreement and understanding of the parties hereto in respect of the subject matter hereof, and supersedes all prior agreements, promises, covenants, arrangements, representations or warranties, whether oral or written, by any party hereto or
any officer, director, employee or representative of any party hereto. No modification or waiver of any provision of this Agreement shall be valid unless it is in writing and signed by the party to be charged therewith, provided,
however, that the consent of the Holders comprising a majority of the shares of Purchaser Common Stock issued to the Holders as Merger Consideration and still held by the Holders shall be required to amend any provision of the Agreement
impacting the rights of the Holders. The waiver or breach of any term or condition of this Agreement shall not be deemed to constitute a waiver of any other breach of the same or any other term or condition. 

2.9 Third Parties. Except as specifically set forth or referred to herein, nothing herein expressed or implied is intended or
shall be construed to confer upon or give to any person or corporation other than the parties hereto and their respective successors or assigns any rights or remedies under or by reason of this Agreement. 

 

 5 

 2.10 Gender; Tense, Etc. Where the context or construction requires, all words
applied in the plural shall be deemed to have been used in the singular, and vice versa; the masculine shall include the feminine and neuter, and vice versa; and the present tense shall include the past and future tense, and vice versa. 

[Remainder of this page left blank intentionally; Signature pages follow] 

 

 6 

 IN WITNESS WHEREOF, each of the undersigned has duly executed this Stockholders’
Agreement as of the date first written above. 
  

			
	MDRNA, INC.
		
	By:	 	 /s/ J. Michael French

	Name: J. Michael French
	Title: President and CEO
	
	HOLDERS
	
	A.M. PAPPAS LIFE SCIENCE VENTURES III, LP
		
	By:	 	 /s/ Ford S. Worthy

	Name: Ford S. Worthy
	Title: Partner
	
	PVIII CEO FUND, LP
		
	By:	 	 /s/ Ford S. Worthy

	Name: Ford S. Worthy
	Title: Partner
	
	AMPERSAND 2006 LIMITED PARTNERSHIP
	
	By: AMP-06 Management Company Limited Partnership, its General Partner
		
	By:	 	AMP-06 MC LLC, its General Partner
		
	By:	 	 /s/ Herbert H. Hooper

	Name: Herbert H. Hooper
	Title: Member

[Stockholders’ Agreement Signature Page] 

			
	NOVARTIS BIOVENTURES LTD.
		
	By:	 	 /s/ H.S. Zivi

	Name: H.S. Zivi
	Title: Deputy Chairman
	
	YED GLOBAL LIFESCIENCE I PARTNERSHIP
		
	By:	 	 /s/ Tsuneo Fujii

	Name: Tsuneo Fujii
	Title: President and Representative Director
	
	YED IV, L.P.
		
	By:	 	 /s/ Tsuneo Fujii

	Name: Tsuneo Fujii
	Title: President and Representative Director
	
	GOLD HILL VENTURE LENDING 03, L.P.
	
	By: Gold Hill Venture Lending Partners 03, LLC, its general partner
		
	By:	 	 /s/ Rob Helm

	Name: Rob Helm
	Title: Managing Director
	
	PETER D. PARKER
	
	 /s/ Peter D. Parker

	Name: Peter D. Parker
	
	CHIANG LI
	
	 /s/ Chiang Li

	Name: Chiang Li

[Stockholders’ Agreement Signature Page] 

 ANNEX I 

HOLDERS 
 A.M.
PAPPAS LIFE SCIENCE VENTURES III, LP 
 PVIII CEO FUND, LP 

AMPERSAND 2006 LIMITED PARTNERSHIP 
 NOVARTIS
BIOVENTURES LTD. 
 YED GLOBAL LIFESCIENCE I PARTNERSHIP 

YED IV, L.P. 
 GOLD HILL VENTURE LENDING 03, L.P.

 PETER D. PARKER 
 CHIANG LI

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