Document:

EX-10.3

 Exhibit 10.3 

EXECUTION VERSION 

INCREMENTAL AMENDMENT NO. 2 

INCREMENTAL AMENDMENT NO. 2, dated as of November 1, 2013 (this “Amendment”), by and among Navios Maritime Partners
L.P., a Marshall Islands limited partnership (the “Company”), and Navios Partners Finance (US) Inc., a Delaware corporation (the “U.S. Borrower” and together with the Company, each individually a
“Borrower” and collectively the “Borrowers”), Morgan Stanley Senior Funding, Inc., as Administrative Agent (the “Administrative Agent”) under the Credit Agreement (as defined below), each
Incremental Term Lender (as defined below), the Required Lenders and each of the other Loan Parties that is a party hereto. 
 RECITALS:

 WHEREAS, reference is hereby made to the Credit Agreement, dated as of June 27, 2013, as amended by Incremental Amendment
No. 1, dated as of October 31, 2013 (as further amended, supplemented, amended and restated or otherwise modified from time to time, the “Credit Agreement”), among the Borrowers, the other Loan Parties, the Administrative
Agent, and the several banks, financial institutions, institutional investors and other entities from time to time party thereto, as Lenders (capitalized terms used but not defined herein having the meaning provided in the Credit Agreement); 

WHEREAS, the Borrowers have hereby notified the Administrative Agent that they are requesting the establishment of an additional
tranche of term loans (the “Incremental Term Loans” and the commitments relating thereto, the “Incremental Term Commitments”) pursuant to Section 2.19(a) of the Credit Agreement in an aggregate principal amount
of $177,500,000; 
 WHEREAS, pursuant to Section 2.19(c) of the Credit Agreement, the Borrowers may obtain Incremental Term
Commitments in respect of Incremental Term Loans by, among other things, entering into one or more Incremental Amendments in accordance with the terms and conditions of the Credit Agreement; 

WHEREAS, the proceeds of the Incremental Term Loans (the “Incremental Proceeds”), together with cash in the amount of
$57,500,000 provided as Cash Collateral by the Company (the “Additional Cash Collateral”) on or prior to the Incremental Amendment Effective Date (as defined below), will be deposited in the Collateral Account to be held, applied
and/or disbursed in a manner as further detailed in this Amendment (i) to fund the purchase of the vessels set forth on Annex I (the “Incremental Identified Vessels”) and/or one or more Qualified Vessels (which may
include a Qualified Vessel owned by a Subsidiary (including a Guarantor) that is not a Mortgaged Vessel Guarantor) and (ii) to pay the costs and expenses related to the incurrence of the Incremental Term Loans and any such acquisition of an
Incremental Identified Vessel and/or one or more Qualified Vessels; 

 WHEREAS, Morgan Stanley Senior Funding, Inc., J.P. Morgan Securities LLC and Citigroup
Global Markets Inc. have acted as Joint Lead Arrangers and Joint Bookrunners in connection with the Incremental Term Loans and this Amendment (together, the “Joint Lead Arrangers”), and Deutsche Bank Securities Inc., S. Goldman
Advisors, LLC, Credit Agricole Corporate and Investment Bank, DVB Capital Markets LLC, ABN AMRO Capital USA LLC and RS Platou Markets AS have acted as Co-Arrangers in connection with the Incremental Term Loans and this Amendment (the
“Co-Arrangers”, and together, with the Lead Arrangers, the “Arrangers”); 
 WHEREAS, the Persons
party to this Amendment as lenders with respect to the Incremental Term Loans (such Persons and any permitted assignees thereof, the “Incremental Term Lenders”) have indicated their willingness to lend such Incremental Term Loans on
the terms and subject to the conditions herein; 
 WHEREAS, pursuant to Section 10.1 of the Credit Agreement, the Loan Parties,
the Administrative Agent and the Required Lenders may amend the Credit Agreement and the other Loan Documents for certain purposes and the Loan Parties desire to amend the Credit Agreement pursuant to Section 10.1 (the “Additional
Amendments”) as set forth below. 
 NOW, THEREFORE, in consideration of the premises and agreements, provisions and
covenants herein contained, the Borrowers, the other Loan Parties, the Incremental Term Lenders party hereto, the Required Lenders party hereto and the Administrative Agent hereby agree as follows: 

ARTICLE I.  

Incremental Amendment 

Section 1.01 Incremental Term Commitments 

(a) Subject to the terms and conditions set forth herein, each Incremental Term Lender severally agrees to make Incremental Term Loans to the
Borrowers on the Incremental Amendment Effective Date (as defined below) in the amount of such Incremental Term Lender’s Incremental Term Commitment as set forth on Schedule A. Pursuant to Section 2.19(b) of the Credit Agreement,
the Incremental Term Loans shall be Term Loans for all purposes under the Credit Agreement and each other Loan Document and shall have terms identical to the Term Loans outstanding under the Credit Agreement immediately prior to the date hereof (the
“Existing Term Loans” and, together with the Incremental Term Loans, the “Term Loans”), which shall include among other things the following terms: 

(b) Maturity Date. The Incremental Term Loans will mature on the Term Loan Maturity Date. 

(c) Amortization. Section 2.3(a) of the Credit Agreement shall be deemed amended to reflect that the Borrowers shall repay to the
Administrative Agent for the ratable account of each Incremental Term Lender, in quarterly installments on the last Business Day of each March, June, September and December, commencing with December 31, 2013, in an

  
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amount equal to 0.25% of the aggregate principal amount of the Incremental Term Loans funded on the Incremental Amendment Effective Date, with the final installment on the Term Loan Maturity Date
equal to the remaining outstanding amount of the Incremental Term Loans. 
 (d) Initial Interest Rates and Interest Periods.
The Borrowers and the Incremental Term Lenders hereby agree that the Incremental Term Loans incurred pursuant to this Amendment will be allocated ratably to each outstanding borrowing of Term Loans that are Eurodollar Rate Loans or ABR Loans under
the Credit Agreement for purposes of determining the initial interest rate thereon and Interest Period therefor. 
 (e)
Credit Agreement Governs. The Incremental Term Loans shall have identical terms as the Existing Term Loans and shall otherwise be subject to the provisions, including any provisions restricting the rights, or regarding the obligations, of the
Loan Parties or any provisions regarding the rights of the Term Lenders, of the Credit Agreement and the other Loan Documents, each reference to a “Term Loan” or “Term Loans” in the Credit Agreement shall be deemed to include the
Incremental Term Loans and other related terms will have correlative meanings mutatis mutandis. 

Section 1.02 Conditions to Effectiveness. Section 1.01 of this Amendment shall become effective on November 1, 2013 (the
“Incremental Amendment Effective Date”) when: 
 (a) this Amendment shall have been executed and delivered by the
Borrowers, the Loan Parties, each Incremental Term Lender party hereto and the Administrative Agent; 
 (b) the Administrative Agent shall
have received copies of bring down personal property Lien, tax and judgment Lien searches received by the Company prior to the Incremental Amendment Effective Date, which shall not reveal the existence of any Liens on or security interest in
Collateral of the Mortgaged Vessel Guarantors or any pledgor of Pledged Equity Interests other than (i) Permitted Liens or (ii) Liens as to which the Administrative Agent has received evidence satisfactory to it that the obligations
secured by such Liens have been fully and finally discharged on or prior to the Incremental Amendment Effective Date; 
 (c) the
Administrative Agent shall have received (i) a certificate of each Loan Party, dated the Incremental Amendment Effective Date, in form and substance reasonably acceptable to the Administrative Agent, with appropriate insertions and attachments,
including certified organizational authorizations, incumbency certifications, the certificate of incorporation or other similar Organizational Document of each Loan Party certified by the relevant authority of the jurisdiction of organization of
such Loan Party and bylaws or other similar Organizational Document of each Loan Party certified by a Responsible Officer as being in full force and effect on the Incremental Amendment Effective Date and (ii) a good standing certificate (in
respect of each jurisdiction where the “good standing” concept exists) for each Loan Party from its jurisdiction of organization; 

(d) the Administrative Agent shall have received a Solvency Certificate, dated the Incremental Amendment Effective Date, which demonstrates
that the Company and the Restricted Subsidiaries, on a consolidated basis, are and, after giving effect to this Amendment and the other transactions contemplated hereby, will be and will continue to be, Solvent; 

  
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 (e) the Administrative Agent and the Arrangers shall have received all fees required to be paid
on or prior to the Incremental Amendment Effective Date, and all expenses required to be paid on the Incremental Amendment Effective Date for which reasonably detailed invoices have been presented (including the reasonable fees and expenses of legal
counsel to the Administrative Agent and the Arrangers) to the Company at least one (1) Business Day prior to Incremental Amendment Effective Date; 

(f) the Administrative Agent shall have received the executed legal opinion of (i) Fried, Frank, Harris, Shriver & Jacobson,
LLP, special counsel to the Loan Parties, (ii) Reeder & Simpson P.C., Marshall Islands and Liberia counsel for the Loan Parties, (iii) Camilleri, Delia, Randon & Associates, Republic of Malta counsel for the Loan Parties
and (iv) Vives y Asociados, Republic of Panama counsel for the Loan Parties, each of which shall be in form and substance reasonably satisfactory to the Administrative Agent; 

(g) the Administrative Agent shall have received a certificate of a Responsible Officer of the Company, dated the Incremental Amendment
Effective Date, which certifies that (i) the conditions of making any extension of credit under Section 4.2 of the Credit Agreement are satisfied as of the Incremental Amendment Effective Date, (ii) the representations and warranties
in Section 3.01 of this Amendment shall be true and correct in all material respects as of the date hereof and (iii) the conditions of making an Incremental Term Loan set forth in Section 2.19(a) of the Credit Agreement are satisfied
as of the Incremental Amendment Effective Date; 
 (h) the Administrative Agent shall have received an amendment to each existing Ship
Mortgage existing prior to the Incremental Amendment Effective Date relating to the Existing Vessels, M/V Navios Joy and M/V Navios Harmony in form and substance reasonably satisfactory to the Administrative Agent, reflecting this Amendment and the
transactions contemplated hereunder; and 
 (i) the Company shall have deposited into the Collateral Account the Additional Cash Collateral
on or prior to the Incremental Amendment Effective Date; 
 provided that, with respect to clauses (f) and (h) of this Section 1.02,
if such items cannot be delivered on the Incremental Amendment Effective Date after the Borrowers’ use of commercially reasonable efforts to do so, then the provision of such items shall not constitute a condition to the effectiveness of this
Amendment but instead shall be required to be delivered within thirty (30) days (or such longer period as agreed to by the Administrative Agent in its sole discretion) of the Incremental Amendment Effective Date. 

Section 1.03 Use of Proceeds. The Incremental Proceeds, together with the Additional Cash Collateral, will be used to fund the
acquisition of the Incremental Identified Vessels (and to pay for any Permitted Repairs thereon and the costs and expenses related to such acquisition) and/or the acquisition of one or more Qualified Vessels in lieu of one or more of such
Incremental Identified Vessels (and to pay for any Permitted Repairs thereon and the costs 

  
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and expenses related to such acquisition) (each such acquisition, a “Vessel Acquisition”) and to pay costs and expenses related to the incurrence of the Incremental Term Loans.
The consideration for each Vessel Acquisition, Permitted Repairs or other cost or expense shall be deemed to have been made to the extent of 75.50% from the Incremental Proceeds and 24.50% from the Additional Cash Collateral (the “Allocation
Ratio”); provided that, if on the one year anniversary of the Incremental Amendment Effective Date (the “Outside Date”), any of the Incremental Proceeds shall not have been applied as provided above in this
Section 1.03 to the acquisition of the Incremental Identified Vessels, other Qualified Vessels or Permitted Repairs or other costs or expenses in relation to the incurrence of the Incremental Term Loans or any such Vessel Acquisition, then, to
the extent such unutilized Incremental Proceeds exceed $5,000,000 (all such unutilized Incremental Proceeds and not just the amount in excess of $5,000,000, the “Unutilized Incremental Proceeds Collateral”), then the Borrowers shall
no later than five (5) Business Days following the Outside Date, apply such Unutilized Incremental Proceeds Collateral (together with other funds not constituting Cash Collateral available to the Borrower to be applied to the payment of any
required prepayment premium and accrued but unpaid interest) to prepay, in accordance with Section 2.5(a) of the Credit Agreement, an aggregate principal amount of Term Loans equal to the amount of such Unutilized Incremental Proceeds
Collateral. Upon consummation of such prepayment, to the extent permitted by the terms of the Credit Agreement (including after giving effect to Section 2.01 of this Amendment, if applicable) the remaining balance of the Additional Cash
Collateral (such remaining amount determined in accordance with the Allocation Ratio described above in this Section 1.03) shall be released from the Collateral Account to a bank account designated by the Company, and shall no longer constitute
Cash Collateral for purposes of the Credit Agreement and the other Loan Documents. 
 Section 1.04 Written Request. By
its execution of this Amendment, the Borrowers hereby deliver and the Administrative Agent hereby acknowledges receipt of this Amendment as the satisfaction of the requirement to give written notice required to the Administrative Agent pursuant to
Section 2.19(a) of the Credit Agreement. 
 ARTICLE II. 

Additional Amendments 

Section 2.01 Additional Amendments of Credit Agreement. Effective as of the Additional Amendment Effective Date (as defined
below), the Required Lenders hereby agree that the Credit Agreement is amended as follows: 
 (a) Section 1.1 of the Credit
Agreement is hereby amended by deleting the definition of “Loan To Value Ratio—Additional Indebtedness” in its entirety, and replacing it with the following language: 

“‘Loan To Value Ratio — Additional Indebtedness”: at any time, in connection with the incurrence of any additional
Indebtedness, the ratio of (x) the aggregate principal amount of Incremental Term Loans and/or Permitted Incremental Indebtedness to be incurred at such time to (y) the sum of (without duplication) (I) the aggregate Fair Market Value
of all Collateral to be purchased by (or 

  
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contributed to) one or more Mortgaged Vessel Guarantors with the proceeds of the issuance of such additional Indebtedness and other funds available to the Company and its Restricted Subsidiaries
on the date of issuance of such additional Indebtedness and (II) any cash proceeds from the incurrence of such additional Indebtedness and any other funds, in each case, deposited (or to be deposited) as Cash Collateral in connection with the
incurrence of such additional Indebtedness.’” 
 (b) Section 10.20(a) of the Credit Agreement is hereby amended by
(i) adding “or” at the end of clause (7) of such Section, (ii) adding “or” at the end of clause (9) of such Section and (iii) adding the following language as a new clause (10) of such Section: 

“(10) additional funds provided by the Borrowers as Cash Collateral in connection with the incurrence of Incremental Term Loans under any
Incremental Amendment including (i) proceeds from the funding of such Incremental Term Loans (the “Incremental Proceeds Cash Collateral”) and (ii) other funds in connection therewith (other than the Incremental Proceeds
Cash Collateral) (the “Other Funds Cash Collateral”);” 
 (c) Section 10.22(c) of the Credit Agreement is hereby
amended by adding the following language at the end of such Section: 
 “Furthermore and notwithstanding any provisions of this
Section 10.22 to the contrary, if in connection with the incurrence of Incremental Term Loans under any Incremental Amendment, the Borrowers shall have prepaid Term Loans with the Incremental Proceeds Cash Collateral in accordance with the
terms of the Incremental Amendment relating to such incurrence, the Borrower shall be entitled to obtain a release of all the Other Funds Cash Collateral, deposited in the Collateral Account in connection with such Incremental Amendment, after the
application of any such Other Funds Cash Collateral in connection with the acquisition of Incremental Identified Vessels (as defined the Incremental Amendment) and/or Qualified Vessels in accordance with the terms of such Incremental
Amendment.” 
 Section 2.02 Additional Amendment Effectiveness. Section 2.01 of this Amendment shall become effective
as of the first date (the “Additional Amendment Effective Date”) on which: 
 (a) this Amendment shall have been executed
and delivered by the Loan Parties, the Administrative Agent and the Required Lenders; and 
 (b) all conditions set forth in
Section 1.02 of this Amendment shall have been satisfied. 

  
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 ARTICLE III.  

Miscellaneous 

Section 3.01 Representations and Warranties. By its execution of this Amendment, each Loan Party hereby certifies
that: 
 (a) This Amendment has been duly authorized by all necessary corporate or other organizational action and has been duly
executed and delivered by each Loan Party that is a party hereto and constitutes a legal, valid and binding obligation of such Loan Party, enforceable against such Loan Party in accordance with its terms, except to the extent the enforceability
thereof may be limited by applicable Debtor Relief Laws affecting creditors’ rights generally and by equitable principles of law (regardless of whether enforcement is sought in equity or at law) and implied covenants of good faith and fair
dealing. 
 (b) The execution, delivery and performance of this Amendment and the other documents executed in connection herewith
(a) do not require any consent or approval of, registration or filing with, or any other action by, any Governmental Authority, except for such as (i) have been obtained or made and are in full force and effect, or (ii) the failure of
which to obtain would not reasonably be expected to result in a Material Adverse Effect, (b) will not violate any law applicable to such Loan Party or the Organization Documents of any Loan Party, except to the extent that such violation would
not reasonably be expected to result in a Material Adverse Effect, (c) will not violate or result in a default under any Contractual Obligation to which such Loan Party is party, except to the extent that such violation or default would not
reasonably be expected to result in a Material Adverse Effect and (d) will not result in the creation or imposition of any Lien on any asset of any Loan Party (other than Permitted Liens). 

(c) As of the Incremental Amendment Effective Date and the Additional Amendment Effective Date and before and after giving effect to this
Amendment, the representations and warranties of the Borrowers and each other Loan Party contained in Article 3 of the Credit Agreement or any other Loan Document shall be true and correct in all material respects (except where such representations
and warranties are already qualified by materiality, in which case such representation and warranty shall be true and correct in all respects) on and as of such date as if made on and as of such date, except to the extent such representations and
warranties expressly relate to an earlier date, in which case such representations and warranties shall have been true and correct in all material respects (except where such representations and warranties are already qualified by materiality, in
which case such representation and warranty shall be true and correct in all respects) as of such earlier date. 
 (d) At the time of and
after giving effect to this Amendment, no Default or Event of Default shall have occurred and be continuing. 
 Section 3.02
Acknowledgments. Each Loan Party hereby expressly acknowledges the terms of this Amendment and reaffirms, as of the date hereof, (i) the covenants and agreements contained in each Loan Document to which it is a party, including, in each
case, such covenants and agreements as in effect immediately after giving effect to this Amendment and the transactions contemplated hereby and (ii) its guarantee of the Obligations (including, without limitation, the Incremental Term Loans)
under the Security Documents and its grant of Liens on the Collateral to secure the Obligations (including, without limitation, the Obligations with respect to the Incremental Term Loans) pursuant to the Security Documents. 

  
 -7- 

 Section 3.03 Amendment, Modification and Waiver. This Amendment may not be
amended, modified or waived except in accordance with Section 10.1 of the Credit Agreement. 
 Section 3.04 Liens
Unimpaired. After giving effect to this Amendment, neither the modification of the Credit Agreement effected pursuant to this Amendment nor the execution, delivery, performance or effectiveness of this Amendment: 

(a) impairs the validity, effectiveness or priority of the Liens granted pursuant to any Loan Document, and such Liens continue unimpaired
with the same priority to secure repayment of all Obligations, whether heretofore or hereafter incurred; or 
 (b) requires that any new
filings be made or other action taken to perfect or to maintain the perfection of such Liens (other than any filing, registration and recordation required in respect of each Ship Mortgage existing prior to the Incremental Amendment Effective Date).

 Section 3.05 Entire Agreement. This Amendment, the Credit Agreement and the other Loan Documents constitute the entire
agreement among the parties hereto with respect to the subject matter hereof and thereof and supersede all other prior agreements and understandings, both written and verbal, among the parties hereto with respect to the subject matter hereof. Except
as expressly set forth herein, this Amendment shall not by implication or otherwise limit, impair, constitute a waiver of, or otherwise affect the rights and remedies of any party under, the Credit Agreement, nor alter, modify, amend or in any way
affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement, all of which are ratified and affirmed in all respects and shall continue in full force and effect. It is understood and agreed that each
reference in each Loan Document to the Credit Agreement, whether direct or indirect, shall hereafter be deemed to be a reference to the Credit Agreement as amended hereby and that this Amendment is a Loan Document. 

Section 3.06 GOVERNING LAW. THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER SHALL BE GOVERNED BY, AND
CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO CONFLICT OF LAWS PRINCIPLES THAT WOULD REQUIRE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION. SECTIONS 10.12 AND 10.15 OF THE CREDIT AGREEMENT ARE
HEREBY INCORPORATED BY REFERENCE INTO THIS AMENDMENT AND SHALL APPLY HERETO. 
 Section 3.07 Severability. Any
provision of this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any
such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. 

Section 3.08 Counterparts. This Amendment may be executed by one or more of the parties to this Amendment on any number of
separate counterparts, and all of said counterparts taken together shall be deemed to constitute one and the same instrument. Delivery 

  
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of an executed signature page of this Amendment or any document or instrument delivered in connection herewith by facsimile transmission or electronic PDF shall be effective as delivery of a
manually executed counterpart of this Amendment or such other document or instrument, as applicable. A set of the copies of this Amendment signed by all the parties shall be lodged with the Borrowers and the Administrative Agent. 

  
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 IN WITNESS WHEREOF, each of the undersigned has caused its duly authorized officer to
execute and deliver this Amendment as of the date first written above. 
  

					
	 MORGAN STANLEY SENIOR FUNDING, INC.,

as Administrative Agent and as a Lender

		
	By:	 	 /s/ Robbie Pearson

		 	Name:	 	Robbie Pearson
		 	Title:	 	Authorized Signatory

 [Incremental Amendment No. 2] 

 
					
	 MORGAN STANLEY SENIOR FUNDING, INC.,

as Incremental Term Lender

		
	By:	 	 /s/ Robbie Pearson

		 	Name:	 	Robbie Pearson
		 	Title:	 	Authorized Signatory

 [Incremental Amendment No. 2] 

							
	COMPANY:	 		 		 	
		 	 NAVIOS MARITIME PARTNERS L.P.,
 as a
Borrower

			
		 	By:	 	 /s/ Vasiliki Papaefthymiou

		 		 	Name:	 	Vasiliki Papaefthymiou
		 		 	Title:	 	Secretary
				
	U.S. BORROWER:	 		 		 	
		 	 NAVIOS PARTNERS FINANCE (US) INC.,

as a Borrower

			
		 	By:	 	 s/ Vasiliki Papaefthymiou

		 		 	Name:	 	Vasiliki Papaefthymiou
		 		 	Title:	 	President and Secretary

 [Incremental Amendment No. 2] 

									
	GUARANTORS:	 	 	 	 	 	 	 	 
		 		 	ALDEBARAN SHIPPING CORPORATION
		 		 	ALEGRIA SHIPPING CORPORATION
		 		 	AURORA SHIPPING ENTERPRISES LTD.
		 		 	CHILALI CORP.
		 		 	CUSTOMIZED DEVELOPMENT S.A.
		 		 	FANTASTIKS SHIPPING CORPORATION
		 		 	FELICITY SHIPPING CORPORATION
		 		 	FLORAL MARINE LTD.
		 		 	GALAXY SHIPPING CORPORATION
		 		 	GEMINI SHIPPING CORPORATION
		 		 	GOLEM NAVIGATION LIMITED
		 		 	HYPERION ENTERPRISES INC.
		 		 	KOHYLIA SHIPMANAGEMENT S.A.
		 		 	KYMATA SHIPPING CO.
		 		 	LIBRA SHIPPING ENTERPRISES CORPORATION
		 		 	ORBITER SHIPPING CORP.
		 		 	PALERMO SHIPPING S.A.
		 		 	PANDORA MARINE INC.
		 		 	PROSPERITY SHIPPING CORPORATION
		 		 	SAGITTARIUS SHIPPING CORPORATION
		 		 	SURF MARITIME CO.
		 		 	PEARL SHIPPING CORPORATION
		 		 	VELVET SHIPPING CORPORATION
		 		 	JOY SHIPPING CORPORATION
		 		 	JTC SHIPPING & TRADING LTD.
		 		 	MICAELA SHIPPING CORPORATION
				
		 		 	By:	 	 /s/ Anna Kalathaki

		 		 		 	Name:	 	Anna Kalathaki
		 		 		 	Title:	 	Treasurer/Director
			
		 		 	NAVIOS MARITIME OPERATING L.L.C.
				
		 		 	By:	 	NAVIOS MARITIME PARTNERS L.P., as its sole member
				
		 		 	By:	 	 /s/ Vasiliki Papaefthymiou

		 		 		 	Name:	 	Vasiliki Papaefthymiou
		 		 		 	Title:	 	Secretary

 [Incremental Amendment No. 2] 

													
	Arrowpoint CLO 2013-1, LTD., as Lender	 		 	Canyon Capital CLO 2006-1, Ltd., as Lender
					
		 		 		 		 	By: Canyon Capital Advisors LLC, its Asset Manager
						
	By:	 	 /s/ Sanjai Bhonsle
	 		 		 		 	
		 	Name:	 	Sanjai Bhonsle	 		 	By:	 	 /s/ Jonathan M. Kaplan

		 	Title:	 	Portfolio Manager	 		 		 	Name:	 	Jonathan M. Kaplan
		 		 		 		 		 	Title:	 	Authorized Signatory
			
	Canyon Capital CLO 2012-1, Ltd., as Lender	 		 	Wasatch CLO Ltd., as Lender
			
	By: Canyon Capital Advisors, its Asset Manager	 		 	By: Invesco Senior Secured Management, Inc. as Portfolio Manager
						
	By:	 	 /s/ Jonathan M. Kaplan
	 		 		 		 	
		 	Name:	 	Jonathan M. Kaplan	 		 	By:	 	 /s/ Kevin Egan

		 	Title:	 	Authorized Signatory	 		 		 	Name:	 	Kevin Egan
		 		 		 		 		 	Title:	 	Authorized Individual
			
	The City of New York Group Trust, as Lender	 		 	QUALCOMM Global Trading Pte. Ltd., as Lender
			
	By: Invesco Senior Secured Management, Inc. as Investment Manager	 		 	By: Invesco Senior Secured Management, Inc. as Investment Manager
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Medical Liability Mutual Insurance Company, as Lender	 		 	North End CLO, Ltd., as Lender
			
	By: Invesco Advisers, Inc. as Investment Manager	 		 	By: Invesco Senior Secured Management, Inc. as Investment Manager
						
	By:	 	 /s/ Kevin Egan
	 		 		 		 	
		 	Name:	 	Kevin Egan	 		 	By:	 	 /s/ Kevin Egan

		 	Title:	 	Authorized Individual	 		 		 	Name:	 	Kevin Egan
		 		 		 		 		 	Title:	 	Authorized Individual

 [Incremental Amendment] 

													
	Marea CLO, Ltd., as Lender	 		 	Nomad CLO, Ltd., as Lender
			
	By: Invesco Senior Secured Management, Inc. as Collateral Manager	 		 	By: Invesco Senior Secured Management, Inc. as Collateral Manager
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Linde Pension Plan Trust, as Lender	 		 	Invesco Senior Loan Fund, as Lender
			
	By: Invesco Senior Secured Management, Inc. as Investment Manager	 		 	By: Invesco Senior Secured Management, Inc. as Sub-advisor
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Invesco Zodiac Funds - Invesco US Senior Loan Fund, as Lender	 		 	Invesco Floating Rate Fund, as Lender
			
	By: Invesco Management S.A. As Investment Manager	 		 	By: Invesco Senior Secured Management, Inc. as Sub-Advisor
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Invesco Senior Income Trust, as Lender	 		 	Avalon IV Capital, Ltd., as Lender
			
	By: Invesco Senior Secured Management, Inc. as Sub-advisor	 		 	By: Invesco Senior Secured Management, Inc. as Asset Manager
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual

 [Incremental Amendment] 

													
	BOC Pension Investment Fund, as Lender	 		 	Diversified Credit Portfolio Ltd., as Lender
			
	By: Invesco Senior Secured Management, Inc. as Attorney in Fact	 		 	By: Invesco Senior Secured Management, Inc. as Investment Adviser
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Invesco Dynamic Credit Opportunities Fund, as Lender	 		 	Children’s Healthcare of Atlanta, Inc., as Lender
			
	By: Invesco Senior Secured Management, Inc. as Sub-advisor	 		 	By: Invesco Senior Secured Management, Inc. as Investment Manager
					
	By:	 	 /s/ Kevin Egan
	 		 	By:	 	 /s/ Kevin Egan

		 	Name:	 	Kevin Egan	 		 		 	Name:	 	Kevin Egan
		 	Title:	 	Authorized Individual	 		 		 	Title:	 	Authorized Individual
			
	Arrowood Indemnity Company, as Lender	 		 	Arrowood Indemnity Company, as administrator of The Pension Plan of Arrowood, as Lender
			
	By: Invesco Senior Secured Management, Inc. as Investment Manager	 		 	By: Invesco Senior Secured Management, Inc. as Investment Manager
						
	By:	 	 /s/ Kevin Egan
	 		 		 		 	
		 	Name:	 	Kevin Egan	 		 	By:	 	 /s/ Kevin Egan

		 	Title:	 	Authorized Individual	 		 		 	Name:	 	Kevin Egan
		 		 		 		 		 	Title:	 	Authorized Individual
			
	Battalion CLO IV Ltd., as Lender	 		 	JPMC Retirement Plan Brigade Bank Loan, as Lender
			
	By: BRIGADE CAPITAL MANAGEMENT LLC As Collateral Manager	 		 	By: BRIGADE CAPITAL MANAGEMENT, LLC As Investment Manager
					
	By:	 	 /s/ James Keogh
	 		 	By:	 	 /s/ James Keogh

		 	Name:	 	James Keogh	 		 		 	Name:	 	James Keogh
		 	Title:	 	Bank Debt Manager	 		 		 	Title:	 	Bank Debt Manager

 [Incremental Amendment] 

													
	BATTALION CLO 2007-I, LTD, as Lender	 		 	BATTALION CLO III LTD., as Lender
			
	By: BRIGADE CAPITAL MANAGEMENT LLC As Collateral Manager	 		 	By: BRIGADE CAPITAL MANAGEMENT LLC As Collateral Manager
					
	By:	 	 /s/ James Keogh
	 		 	By:	 	 /s/ James Keogh

		 	Name:	 	James Keogh	 		 		 	Name:	 	James Keogh
		 	Title:	 	Bank Debt Manager	 		 		 	Title:	 	Bank Debt Manager
			
	GLG Ore Hill CLO 2013-1, Ltd., as Lender	 		 	Manulife Floating Rate Income Fund, as Lender
					
	By: GLG Ore Hill LLC as Collateral Manager	 		 		 		 	
		 		 		 		 	By:	 	 /s/ Edward Myers

		 		 		 		 		 	Name:	 	Edward Myers
	By:	 	 /s/ Frederick Wahl
	 		 		 	Title:	 	Director
		 	Name:	 	Frederick Wahl	 		 		 		 	
		 	Title:	 	Managing Director	 		 		 		 	
			
	Morgan Stanley Senior Funding, Inc., as Lender	 		 	THL CREDIT WIND RIVER 2013-1 CLO LTD., as Lender
				
	By:	 	 /s/ Adam Savarese
	 		 	By: THL Credit Senior Loan Strategies LLC, as Investment Manager
		 	Name:	 	Adam Savarese	 		 		 		 	
		 	Title:	 	Authorized Signatory	 		 		 		 	
		 		 		 		 	By:	 	 /s/ Kathleen A Zarn

		 		 		 		 		 	Name:	 	Kathleen A Zarn
		 		 		 		 		 	Title:	 	Vice President
			
	TRALEE CLO II, LTD., as Lender	 		 	Seix Multi-Sector Absolute Return Fund L.P., as Lender
			
	By: Par-Four Investment Management, LLC As Collateral Manager	 		 	By: Seix Multi-Sector Absolute Return Fund GP LLC, in its capacity as sole general partner
					
		 		 		 		 	By: Seix Investment Advisors LLC, its sole member
						
	By:	 	 /s/ Dennis Gorczyca
	 		 		 		 	
		 	Name:	 	Dennis Gorczyca	 		 		 		 	
		 	Title:	 	Managing Director	 		 	By:	 	 /s/ George Goudelias

		 		 		 		 		 	Name:	 	George Goudelias
		 		 		 		 		 	Title:	 	Managing Director

 [Incremental Amendment] 

													
	RidgeWorth Funds – Total Return Bond Fund, as Lender	 		 	Emory University, as Lender
					
	By:	 	Seix Investment Advisors LLC, as Subadviser	 		 	By:	 	Seix Investment Advisors LLC, in its capacity as Investment Manager
						
	By:	 	 /s/ George Goudelias
	 		 		 		 	
		 	Name:	 	George Goudelias	 		 	By:	 	 /s/ George Goudelias

		 	Title:	 	Managing Director	 		 		 	Name:	 	George Goudelias
		 		 		 		 		 	Title:	 	Managing Director
			
	CNI Charter Funds – Fixed Income Opportunities Fund, as Lender	 		 	RidgeWorth Funds - Seix Floating Rate High Income Fund, as Lender
					
	By:	 	Seix Investment Advisors LLC, as Subadviser	 		 	By:	 	Seix Investment Advisors LLC, as Subadviser
					
	By:	 	 /s/ George Goudelias
	 		 	By:	 	 /s/ George Goudelias

		 	Name:	 	George Goudelias	 		 		 	Name:	 	George Goudelias
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director
			
	Blue Cross of Idaho Health Service, Inc., as Lender	 		 	DUANE STREET CLO IV, LTD., as Lender
					
	By:	 	Seix Investment Advisors LLC, as Investment Manager	 		 	By:	 	Napier Park Global Capital, LLC, As Collateral Manager
					
	By:	 	 /s/ George Goudelias
	 		 	By:	 	 /s/ Roger Yee

		 	Name:	 	George Goudelias	 		 		 	Name:	 	Roger Yee
		 	Title:	 	Managing Director	 		 		 	Title:	 	Director
			
	REGATTA II FUNDING LP, as Lender	 		 	JPMorgan Core Plus Bond Fund, as Lender
				
	By:	 	Napier Park Global Capital, LLC, attorney-in-fact	 		 	
		 		 		 		 	By:	 	 /s/ William J. Morgan

	By:	 	 /s/ Roger Yee
	 		 		 	Name:	 	William J. Morgan
		 	Name:	 	Roger Yee	 		 		 	Title:	 	Managing Director
		 	Title:	 	Director	 		 		 		 	

 [Incremental Amendment] 

													
	Louisiana State Employees’ Retirement System, as Lender	 		 	Southern Ute Permanent Fund, as Lender
				
		 		 	By:	 	 /s/ William J. Morgan

	By:	 	 /s/ William J. Morgan
	 		 		 	Name:	 	William J. Morgan
		 	Name:	 	William J. Morgan	 		 		 	Title:	 	Managing Director
		 	Title:	 	Managing Director	 		 		 		 	
			
	JPMorgan Strategic Income Opportunities Fund, as Lender	 		 	National Railroad Retirement Investment Trust, as Lender
					
	By:	 	 /s/ William J. Morgan
	 		 	By:	 	 /s/ William J. Morgan

		 	Name:	 	William J. Morgan	 		 		 	Name:	 	William J. Morgan
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director
			
	JPMorgan Leveraged Loans Master Fund LP, as Lender	 		 	Consumer Program Administrators, Inc., as Lender
					
	By:	 	 /s/ William J. Morgan
	 		 	By:	 	 /s/ William J. Morgan

		 	Name:	 	William J. Morgan	 		 		 	Name:	 	William J. Morgan
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director
			
	Advanced Series Trust – AST JPMorgan Strategic Opportunities Portfolio, as Lender	 		 	LVIP – JP Morgan High Yield Fund, as Lender
						
		 		 		 		 	By:	 	 /s/ William J. Morgan

	By:	 	 /s/ William J. Morgan
	 		 		 	Name:	 	William J. Morgan
		 	Name:	 	William J. Morgan	 		 		 	Title:	 	Managing Director
		 	Title:	 	Managing Director	 		 		 		 	

 [Incremental Amendment] 

													
	Advanced Series Trust – AST High Yield Portfolio, as Lender	 		 	Hewitt Ennisknupp Inc., as Lender
						
		 		 		 		 	By:	 	 /s/ William J. Morgan

	By:	 	 /s/ William J. Morgan
	 		 		 	Name:	 	William J. Morgan
		 	Name:	 	William J. Morgan	 		 		 	Title:	 	Managing Director
		 	Title:	 	Managing Director	 		 		 		 	
			
	J.P. Morgan Chase Bank NA as Trustee of the JP Morgan Chase Retirement Plan, as Lender	 		 	Advanced Series Trust – AST J.P. Morgan Global Thematic Portfolio, as Lender
					
	By:	 	 /s/ William J. Morgan
	 		 	By:	 	 /s/ William J. Morgan

		 	Name:	 	William J. Morgan	 		 		 	Name:	 	William J. Morgan
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director
			
	J.P. Morgan Floating Rate Income Fund, as Lender	 		 	Pacholder High Yield Fund Inc., as Lender
					
	By:	 	 /s/ William J. Morgan
	 		 	By:	 	 /s/ William J. Morgan

		 	Name:	 	William J. Morgan	 		 		 	Name:	 	William J. Morgan
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director
			
	Commingled Pension Trust Fund (High Yield) of JPMorgan Chase Bank, N.A., as Lender	 		 	JPMorgan Income Builder Fund, as Lender
						
		 		 		 		 	By:	 	 /s/ William J. Morgan

	By:	 	 /s/ William J. Morgan
	 		 		 	Name:	 	William J. Morgan
		 	Name:	 	William J. Morgan	 		 		 	Title:	 	Managing Director
		 	Title:	 	Managing Director	 		 		 		 	
			
	JPMorgan High Yield Fund, as Lender	 		 	Remuda Capital Management, LTD., as Lender
					
	By:	 	 /s/ William J. Morgan
	 		 	By:	 	 /s/ William J. Morgan

		 	Name:	 	William J. Morgan	 		 		 	Name:	 	William J. Morgan
		 	Title:	 	Managing Director	 		 		 	Title:	 	Managing Director

 [Incremental Amendment] 

													
	Menard, Inc., as Lender	 		 	Metropolitan West Floating Rate Income Fund, as Lender
						
	By:	 	 /s/ William J. Morgan
	 		 		 		 	
		 	Name:	 	William J. Morgan	 		 	By:	 	 /s/ George Winn

		 	Title:	 	Managing Director	 		 		 	Name:	 	George Winn
		 		 		 		 		 	Title:	 	Senior Vice President
						
		 		 		 		 	By:	 	 /s/ Eric Chan

		 		 		 		 		 	Name:	 	Eric Chan
		 		 		 		 		 	Title:	 	Senior Vice President
			
	Figueroa CLO 2013-1, Ltd., as Lender	 		 	Figueroa CLO 2013-2, Ltd., as Lender
					
	By:	 	 /s/ George Winn
	 		 	By:	 	 /s/ George Winn

		 	Name:	 	George Winn	 		 		 	Name:	 	George Winn
		 	Title:	 	Senior Vice President	 		 		 	Title:	 	Senior Vice President
					
	By:	 	 /s/ Eric Chan
	 		 	By:	 	 /s/ Eric Chan

		 	Name:	 	Eric Chan	 		 		 	Name:	 	Eric Chan
		 	Title:	 	Senior Vice President	 		 		 	Title:	 	Senior Vice President
			
	Sound Point CLO I, LTD., as a Lender	 		 	Sound Point CLO III, LTD., as a Lender
			
	By: Sound Point Capital Management, LP as Collateral Manager	 		 	By: Sound Point Capital Management, LP as Collateral Manager
					
	By:	 	 /s/ Mike Abatemarco
	 		 	By:	 	 /s/ Mike Abatemarco

		 	Name:	 	Mike Abatemarco	 		 		 	Name:	 	Mike Abatemarco
		 	Title:	 	Director of Operations	 		 		 	Title:	 	Managing Director

 [Incremental Amendment] 

													
	COMMONWEALTH OF PENNSYLVANIA, as a Lender	 		 	Sound Point Senior Floating Rate Master Fund, LP., as a Lender
			
	By: Sound Point Capital Management, LP as Collateral Manager	 		 	By: Sound Point Capital Management, LP as Collateral Manager
					
	By:	 	 /s/ Mike Abatemarco
	 		 	By:	 	 /s/ Mike Abatemarco

		 	Name:	 	Mike Abatemarco	 		 		 	Name:	 	Mike Abatemarco
		 	Title:	 	Director of Operations	 		 		 	Title:	 	Director of Operations
			
	SOUND POINT FLOATING RATE INCOME FUND, as a Lender	 		 	WhiteHorse VII, Ltd., as Lender
			
	By: Sound Point Capital Management, LP as Collateral Manager	 		 	By: H.I.G. WhiteHorse Capital, LLC as Collateral Manager
				
		 		 	By:	 	 /s/ Richard Siegel

	By:	 	 /s/ Mike Abatemarco
	 		 		 	Name:	 	Richard Siegel
		 	Name:	 	Mike Abatemarco	 		 		 	Title:	 	Authorized Officer
		 	Title:	 	Director of Operations	 		 		 		 	
			
	Atrium X, as Lender	 		 	Atrium VII, as Lender
				
	By: Credit Suisse Asset Management, LLC, as portfolio manager	 		 	By:	 	Credit Suisse Asset Management, LLC, as portfolio manager
					
	By:	 	 /s/ Louis Farah
	 		 	By:	 	 /s/ Louis Farah

		 	Name:	 	Louis Farah	 		 		 	Name:	 	Louis Farah
		 	Title:	 	Authorized Signatory	 		 		 	Title:	 	Authorized Signatory
			
	Atrium VIII, as Lender	 		 	Bentham Wholesale Syndicated Loan Fund, as Lender
			
	By: Credit Suisse Asset Management, LLC, as portfolio manager	 		 	By: Credit Suisse Asset Management, LLC, as Agent (Sub-advisor) to Challenger Investment Services Limited, the Responsible Entity for Bentham Wholesale Syndicated Loan Fund
	By:	 	 /s/ Louis Farah
	 		 	
		 	Name:	 	Louis Farah	 		 	
		 	Title:	 	Authorized Signatory	 		 	By:	 	 /s/ Louis Farah

		 		 		 		 		 	Name:	 	Louis Farah
		 		 		 		 		 	Title:	 	Authorized Signatory

 [Incremental Amendment] 

													
	Credit Suisse Nova (LUX), as Lender	 		 	Madison Park Funding VII, Ltd., as Lender
			
	By: Credit Suisse Asset Management, LLC, or Credit Suisse Asset Management Limited, each as Co-Investment Advisor to Credit Suisse Fund Management S.A., management company for Credit Suisse Nova (Lux)	 		 	By: Credit Suisse Asset Management, LLC, as portfolio manager
		 		 		 		 	By:	 	 /s/ Louis Farah

		 		 		 		 		 	Name:	 	Louis Farah
		 		 		 		 		 	Title:	 	Authorized Signatory
	By:	 	 /s/ Louis Farah
	 		 		 		 	
		 	Name:	 	Louis Farah	 		 		 		 	
		 	Title:	 	Authorized Signatory	 		 		 		 	
			
	Madison Park Funding VIII, Ltd., as Lender	 		 	Commonwealth of Pennsylvania Treasury Department, as Lender
			
	By: Credit Suisse Asset Management, LLC, as portfolio manager	 		 	By: Credit Suisse Asset Management, LLC, as its investment advisor
						
	By:	 	 /s/ Louis Farah
	 		 		 		 	
		 	Name:	 	Louis Farah	 		 	By:	 	 /s/ Louis Farah

		 	Title:	 	Authorized Signatory	 		 		 	Name:	 	Louis Farah
		 		 		 		 		 	Title:	 	Authorized Signatory
			
	Credit Suisse Dollar Senior Loan Fund, Ltd., as Lender	 		 	CAVALRY CLO II, as Lender
			
	By: Credit Suisse Asset Management, LLC, as investment manager	 		 	By: Regiment Capital Management, LLC, its Investment Adviser
					
	By:	 	 /s/ Louis Farah
	 		 	By:	 	 /s/ William J. Heffron

		 	Name:	 	Louis Farah	 		 		 	Name:	 	William J. Heffron
		 	Title:	 	Authorized Signatory	 		 		 	Title:	 	Authorized Signatory

 [Incremental Amendment]EX-10.1

 Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT 

THIS SECURITIES PURCHASE AGREEMENT (this
“Agreement”) is dated as of November 1, 2013, by and among Ignyta, Inc., a Nevada corporation (the “Company”) (f.k.a. Infinity Oil & Gas Company), and each purchaser identified on the
signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). 

RECITALS 

A. The Company and each Purchaser is executing and delivering this Agreement in reliance upon the exemption from securities
registration afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Rule 506 of Regulation D (“Regulation D”) as promulgated by the United
States Securities and Exchange Commission (the “Commission”) under the Securities Act. 
 B. Each Purchaser,
severally and not jointly, wishes to purchase, and the Company wishes to sell, upon the terms and conditions stated in this Agreement, that aggregate number of shares of common stock, par value $0.00001 per share (the “Common
Stock”), of the Company, determined as set forth in Section 2.1(a) below (which aggregate amount for all Purchasers together shall be collectively referred to herein as the “Shares”). 

C. The Shares may also be referred to herein as the “Securities”. 

D. The Company has engaged Ladenburg Thalmann & Co. as its exclusive placement agent (the “Placement
Agent”) for the offering of the Shares on a “best efforts” basis. 
 E. Contemporaneously with the execution
and delivery of this Agreement, the parties hereto are executing and delivering a Registration Rights Agreement, substantially in the form attached hereto as Exhibit A (the “Registration Rights Agreement”),
pursuant to which, among other things, the Company will agree to provide certain registration rights with respect to the Shares under the Securities Act and the rules and regulations promulgated thereunder and applicable state securities laws. 

NOW, THEREFORE, in consideration of the mutual covenants contained in this Agreement, and for other good
and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Company and the Purchasers hereby agree as follows: 

ARTICLE 1 
 DEFINITIONS

 1.1 Definitions. In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the
following terms shall have the meanings indicated in this Section 1.1: 
 “Action” means any action, suit,
inquiry, notice of violation, proceeding (including any partial proceeding such as a deposition) or investigation pending or, to the Company’s Knowledge, threatened in writing (or otherwise) against the Company or any of its properties or any
officer, director or employee of the Company as of the date hereof acting in his or her capacity as an officer, director or employee of the Company before or by any federal, state, county, local or foreign court, arbitrator, governmental or
administrative agency, regulatory authority, stock market, stock exchange or trading facility. 
 “Additional
Shares” has the meaning set forth in Section 4.3. 

  
 1. 

 “Affiliate” means, with respect to any Person, any other Person that,
directly or indirectly through one or more intermediaries, Controls, is controlled by or is under common control with such Person, as such terms are used in and construed under Rule 144. With respect to a Purchaser, any investment fund or
managed account that is managed on a discretionary basis by the same investment manager as such Purchaser will be deemed to be an Affiliate of such Purchaser. 

“Business Day” means a day, other than a Saturday or Sunday, on which banks in New York City are open for the general
transaction of business. 
 “Buy-In” has the meaning set forth in Section 4.1(f). 

“Buy-In Price” has the meaning set forth in Section 4.1(f). 

“Closing” means the closing of the purchase by the Purchasers listed on Annex A hereto and sale by the Company
of Shares to such Purchasers pursuant to this Agreement on the Closing Date as provided in Section 2.1(a) hereof. 

“Closing Date” means the third (3rd) Trading Day after the
date on which this Agreement has been executed and delivered by all parties hereto or such earlier date as the parties hereto shall mutually agree, unless on such date the conditions set forth in Sections 2.1, 2.2, 5.1 and 5.2 (other than those
to be satisfied at the Closing) shall not have been satisfied or waived, in which case the Closing Date shall be on the third (3rd) Trading Day after the date on which the last to be
satisfied or waived of the conditions set forth in Sections 2.1, 2.2, 5.1 and 5.2 (other than those to be satisfied at the Closing) shall have been satisfied or waived. 

“Common Stock” has the meaning set forth in the Recitals, and also includes any securities into which the Common Stock
may hereafter be reclassified or changed. 
 “Company Counsel” means Morrison & Foerster LLP. 

“Company Deliverables” has the meaning set forth in Section 2.2(a). 

“Company’s Knowledge” means with respect to any statement made to the knowledge of the Company, that the
statement is based upon the actual knowledge of the officers of the Company who, as of the date hereof, have responsibility for the matter or matters that are the subject of the statement. 

“Compliance Certificate” has the meaning set forth in Section 2.2(a)(vi). 

“Control” (including the terms “controlling”, “controlled” by or
“under common control with”) means the possession, direct or indirect, of the power to direct or cause the direction of the management and policies of a Person, whether through the ownership of voting securities, by contract or otherwise.

 “Deadline Date” has the meaning set forth in Section 4.1(f). 

“Dilutive Issuance” has the meaning set forth in Section 4.3. 

“Disclosure Materials” has the meaning set forth in Section 3.1(h). 

“Disclosure Schedule” has the meaning set forth in Section 3.1. 

“Discounted Purchase Price” has the meaning set forth in Section 4.3. 

  
 2. 

 “DTC” has the meaning set forth in Section 4.1(c). 

“Environmental Laws” has the meaning set forth in Section 3.1(l). 

“Evaluation Date” has the meaning set forth in Section 3.1(u). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, or any successor statute, and the rules and
regulations promulgated thereunder. 
 “Excluded Securities” has the meaning set forth in Section 4.3. 

“FDA” has the meaning set forth in Section 3.1(o). 

“Future Financings” has the meaning set forth in Section 3.2(q). 

“GAAP” means U.S. generally accepted accounting principles, as applied by the Company. 

“Indemnified Person” has the meaning set forth in Section 4.9(b). 

“Intellectual Property” has the meaning set forth in Section 3.1(r). 

“Irrevocable Transfer Agent Instructions” means, with respect to the Company, the Irrevocable Transfer Agent
Instructions, in the form of Exhibit C, executed by the Company and delivered to and acknowledged in writing by the Transfer Agent. 

“Lien” means any material lien, charge, claim, encumbrance, security interest, right of first refusal, preemptive
right or other restrictions of any kind. 
 “Material Adverse Effect” means a material adverse effect on the results
of operations, assets, business or financial condition of the Company, except that any of the following, either alone or in combination, shall not be deemed a Material Adverse Effect: (i) effects caused by changes or circumstances affecting
general market conditions in the U.S. economy or which are generally applicable to the industry in which the Company operates provided that such effects are not borne disproportionately by the Company, (ii) effects resulting from or relating to
the announcement or disclosure of the sale of the Securities or other transactions contemplated by this Agreement, or (iii) effects caused by any event, occurrence or condition resulting from or relating to the taking of any action in
accordance with this Agreement. 
 “Material Contract” means any contract of the Company that has been filed as an
exhibit to the SEC Reports pursuant to Item 601(b)(4) or Item 601(b)(10) of Regulation S-K (including, for purposes hereof, any contracts that are required to be filed as an exhibit to a Form 10). 

“Material Permits” has the meaning set forth in Section 3.1(p). 

“New York Courts” means the state and federal courts sitting in the City of New York, Borough of Manhattan. 

“Outside Date” means November 15, 2013. 

  
 3. 

 “Person” means an individual, corporation, partnership, limited liability
company, trust, business trust, association, joint stock company, joint venture, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed herein. 

“Principal Trading Market” means the Trading Market on which the Common Stock is primarily listed on or quoted for
trading, which, as of the date of this Agreement and the Closing Date, shall be the OTC Bulletin Board. 
 “Press
Release” has the meaning set forth in Section 4.7. 
 “Proceeding” means an action, claim, suit,
investigation or proceeding (including, without limitation, an investigation or partial proceeding, such as a deposition), whether commenced or threatened. 

“Purchase Price” means $6.00 per share of Common Stock. 

“Purchaser Deliverables” has the meaning set forth in Section 2.2(b). 

“Purchaser Party” has the meaning set forth in Section 4.9(a). 

“Registration Statement” means a registration statement meeting the requirements set forth in the Registration Rights
Agreement and covering the resale by the Purchasers of the Registrable Securities (as defined in the Registration Rights Agreement). 

“Required Approvals” has the meaning set forth in Section 3.1(e). 

“Reverse Merger Transaction” means the transaction whereby the Company (f.k.a. Infinity Oil & Gas Company)
issued a certain number of shares of Common Stock in exchange for 100% of the ownership interest of Ignyta Operating, Inc. Upon completion of the Reverse Merger Transaction, Ignyta Operating, Inc. became a direct wholly-owned Subsidiary of the
Company. 
 “Rule 144” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as
such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule. 

“SEC Reports” has the meaning set forth in Section 3.1(h). 

“Secretary’s Certificate” has the meaning set forth in Section 2.2(a)(vi). 

“Short Sales” include, without limitation, (i) all “short sales” as defined in Rule 200
promulgated under Regulation SHO under the Exchange Act, whether or not against the box, and all types of direct and indirect stock pledges, forward sale contracts, options, puts, calls, short sales, swaps, “put equivalent positions”
(as defined in Rule 16a-1(h) under the Exchange Act) and similar arrangements (including on a total return basis), and (ii) sales and other transactions through non-U.S. broker dealers or foreign regulated brokers. 

“Stock Certificates” has the meaning set forth in Section 2.2(a)(iv). 

“Subscription Amount” has the meaning set forth in Section 2.1(a). 

  
 4. 

 “Subsidiary” means any entity in which the Company, directly or
indirectly, owns capital stock or holds an equity or similar interest. 
 “Trading Affiliate” has the meaning set
forth in Section 3.2(h). 
 “Trading Day” means (i) a day on which the Common Stock is listed or quoted
and traded on its Principal Trading Market (unless the Principal Trading Market is the OTC Bulletin Board or the “pink sheets”), or (ii) if the Common Stock is not listed on a Trading Market (other than the OTC Bulletin Board or the
OTC QB, OTC QX or “pink sheets” tier of the OTC Markets Group, Inc.), a day on which the Common Stock is traded in the over-the-counter market, as reported by the OTC Bulletin Board, or (iii) if the Common Stock is not quoted on any
Trading Market (other than the OTC QB, OTC QX or “pink sheets” tier of the OTC Markets Group, Inc.), a day on which the Common Stock is quoted in the over-the-counter market as reported by the OTC QB, OTC QX or “pink sheets” tier
of the OTC Markets Group, Inc. (or any similar organization or agency succeeding to its functions of reporting prices); provided, that in the event that the Common Stock is not listed or quoted as set forth in (i), (ii) and
(iii) hereof, then Trading Day shall mean a Business Day. 
 “Trading Market” means whichever of the New York
Stock Exchange, the NYSE-MKT, the Nasdaq Global Select Market, the Nasdaq Global Market, the Nasdaq Capital Market, the OTC Bulletin Board, the OTC QB, OTC QX or “pink sheets” tier of the OTC Markets Group, Inc. (or any similar
organization or agency succeeding to its functions of reporting prices) on which the Common Stock is listed or quoted for trading on the date in question. 

“Transaction Documents” means this Agreement, the Registration Rights Agreement, the annexes and exhibits attached
hereto and thereto, the Irrevocable Transfer Agent Instructions and any other documents or agreements executed in connection with the transactions contemplated hereunder. 

“Transfer Agent” means Olde Monmouth Stock Transfer Co., Inc., or any successor transfer agent for the Company. 

“Unlegended Certificate” has the meaning set forth in Section 4.1(f). 

ARTICLE 2 
 PURCHASE AND
SALE 
 2.1 Closing. 

(a) Amount. Subject to the terms and conditions set forth in this Agreement, at the Closing, the Company shall issue and sell to each
Purchaser listed on Annex A hereto, and each Purchaser listed on Annex A hereto shall, severally and not jointly, purchase from the Company, such number of Shares of Common Stock equal to the quotient resulting from dividing
(i) the aggregate purchase price for such Purchaser, as indicated below such Purchaser’s name on its signature page of this Agreement (the “Subscription Amount”) by (ii) the Purchase Price, rounded down to the
nearest whole Share. 
 (b) Closing. The Closing of the purchase and sale of the Shares shall take place at the offices of Company
Counsel, 12531 High Bluff Drive, Suite 100, San Diego, California on the Closing Date or at such other locations or remotely by facsimile transmission or other electronic means as the parties may mutually agree. 

  
 5. 

 (c) Form of Payment. On the Closing Date, (i) each Purchaser listed on Annex A
hereto shall wire its Subscription Amount, in United States dollars and in immediately available funds, in the amount set forth as the “Aggregate Purchase Price (Subscription Amount)” indicated below such Purchaser’s name on the
applicable signature page hereto by wire transfer to the Company’s account, as set forth in instructions previously provided to the Purchasers, and (ii) the Company shall irrevocably instruct the Transfer Agent to deliver to each Purchaser
listed on Annex A hereto one or more stock certificates, free and clear of all restrictive and other legends except as expressly provided in Section 4.1(b) hereof, evidencing the number of Shares such Purchaser is purchasing as is
calculated in accordance with Section 2.1(a) above, within three (3) Business Days after the Closing. 
 2.2 Closing
Deliveries.  
 (a) On or prior to the Closing with respect to the Purchasers listed on Annex A hereto, the Company
shall issue, deliver or cause to be delivered to such Purchaser the following (the “Company Deliverables”): 

(i) this Agreement, duly executed by the Company; 

(ii) a legal opinion of Company Counsel dated as of the Closing Date and addressed to such Purchasers; 

(iii) the Registration Rights Agreement, duly executed by the Company; 

(iv) a copy of the duly executed Irrevocable Transfer Agent Instructions delivered to and acknowledged in writing by the Transfer
Agent, relating to the issuance of stock certificates, free and clear of all restrictive and other legends except as provided in Section 4.1(b) hereof, evidencing the Shares subscribed for by the Purchasers hereunder to be registered in the
names provided by the Purchasers as set forth on the Stock Certificate Questionnaire included as Exhibit B-2 hereto (the “Stock Certificates”) and delivered to the Company pursuant to Section 2.2(b)(iv), with
the original Stock Certificates to be delivered to the addresses provided by the Purchasers on such questionnaires within three (3) Business Days following the Closing; 

(v) a certificate of the Secretary of the Company (the “Secretary’s Certificate”), dated as of the
Closing Date, (a) certifying the resolutions adopted by the Board of Directors of the Company or a duly authorized committee thereof approving the transactions contemplated by this Agreement and the other Transaction Documents and the issuance
of the Securities, (b) certifying the current versions of the certificate of incorporation, as amended, and bylaws of the Company and (c) certifying as to the signatures and authority of persons signing the Transaction Documents and
related documents on behalf of the Company, in the form attached hereto as Exhibit D; 
 (vi) a certificate (the
“Compliance Certificate”), dated as of the Closing Date and signed by the Company’s Chief Executive Officer or its Chief Financial Officer, certifying to the fulfillment of the conditions specified in
Sections 5.1(a) and (b) in the form attached hereto as Exhibit E. 
 (vii) a certificate evidencing the
formation and good standing of the Company issued by the Secretary of State of the State of Nevada, as of a date within five (5) days of the Closing Date; 

(viii) a certificate evidencing the Company’s qualification as a foreign corporation and good standing issued by the Secretary of
State of the State of California, as of a date within ten (10) days of the Closing Date; and 

  
 6. 

 (ix) a certified copy of the Certificate of Incorporation, as certified by the Secretary
of State of the State of Nevada, as of a date within ten (10) days of the Closing Date. 
 (b) On or prior to the Closing with
respect to the Purchasers listed on Annex A hereto, each Purchaser shall deliver or cause to be delivered to the Company the following (the “Purchaser Deliverables”): 

(i) this Agreement, duly executed by such Purchaser; 

(ii) its Subscription Amount, in United States dollars and in immediately available funds, by wire transfer to the Company’s
account as previously provided to the Purchasers; 
 (iii) a fully completed and duly executed Selling Stockholder Questionnaire in
the form attached as Annex B to the Registration Rights Agreement; and 
 (iv) a fully completed and duly executed Accredited
Investor Questionnaire and Stock Certificate Questionnaire in the forms attached hereto as Exhibits B-1 and B-2, respectively. 

ARTICLE 3 

REPRESENTATIONS AND WARRANTIES 

3.1 Representations and Warranties of the Company. The Company hereby represents and warrants as of the date hereof and the Closing
Date (except for the representations and warranties that speak as of a specific date, which shall be made as of such date), to each of the Purchasers that, except as disclosed in the SEC Reports and the disclosure schedules delivered by the Company
hereunder (the “Disclosure Schedules”), which shall be deemed a part hereof and shall qualify any representations made by the Company herein to the extent of the applicable disclosure: 

(a) Subsidiaries. The Company has no direct or indirect Subsidiaries other than Ignyta Operating, Inc., a Delaware corporation. 

(b) Organization and Qualification. The Company is an entity duly incorporated, validly existing and in good standing under the laws of
the State of Delaware, with the requisite corporate power and authority to own or lease and use its properties and assets and to carry on its business as currently conducted. The Company is not in violation of any of the provisions of its
certificate of incorporation or bylaws. The Company is duly qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it
makes such qualification necessary, except where the failure to be so qualified or in good standing, as the case may be, would not have a Material Adverse Effect. 

(c) Authorization; Enforcement; Validity. The Company has the requisite corporate power and authority to enter into and to consummate
the transactions contemplated by each of the Transaction Documents to which it is a party and otherwise to carry out its obligations hereunder and thereunder. The execution and delivery of each of the Transaction Documents to which it is a party by
the Company and the consummation by it of the transactions contemplated hereby and thereby (including, but not limited to, the sale and delivery of the Shares) have been duly authorized by all necessary corporate action on the part of the Company,
and no further corporate action is required by the Company, its Board of Directors or its stockholders in connection therewith other than in connection with the Required Approvals. Each of the Transaction Documents to which it is a party has been
(or upon delivery will have been) duly executed by the Company and is, or when delivered in accordance with the terms hereof, will, 

  
 7. 

 
constitute the legal, valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except as such enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies or by other equitable principles of general application or insofar as
indemnification and contribution provisions may be limited by applicable law. There are no shareholder agreements, voting agreements, or other similar arrangements with respect to the Company’s capital stock to which the Company is a party or,
to the Company’s Knowledge, between or among any of the Company’s stockholders. 
 (d) No Conflicts. The execution,
delivery and performance by the Company of the Transaction Documents to which it is a party and the consummation by the Company of the transactions contemplated hereby or thereby (including, without limitation, the issuance of the Shares) do not and
will not (i) conflict with or violate any provisions of the Company’s certificate of incorporation or bylaws or otherwise result in a violation of the organizational documents of the Company, (ii) conflict with, or constitute a
default (or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties or assets of the Company or give to others any rights of termination, amendment, acceleration
or cancellation (with or without notice, lapse of time or both) of, any Material Contract or (iii) subject to the Required Approvals, result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction
of any court or governmental authority to which the Company is subject (including federal and state securities laws and regulations and the rules and regulations, assuming the correctness of the representations and warranties made by the Purchasers
herein, of any self regulatory organization to which the Company or its securities are subject, including all applicable Trading Markets), or by which any property or asset of the Company is bound or affected), except in the case of clause
(ii) and clause (iii) such as would not individually have a Material Adverse Effect. 
 (e) Filings, Consents and
Approvals. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other
Person in connection with the execution, delivery and performance by the Company of the Transaction Documents (including the issuance of the Securities), other than (i) the filing with the Commission of one or more Registration Statements in
accordance with the requirements of the Registration Rights Agreement, (ii) filings required by applicable state securities laws, (iii) the filing of a Notice of Sale of Securities on Form D with the Commission under Regulation D
of the Securities Act, (iv) the filing of any requisite notices and/or application(s) to the Principal Trading Market for the issuance and sale of the Shares and the listing of the Shares for trading or quotation, as the case may be, thereon in
the time and manner required thereby, (v) the filings required in accordance with Section 4.7 of this Agreement and (vi) those that have been made or obtained prior to the date of this Agreement (collectively, the “Required
Approvals”). 
 (f) Issuance of the Securities. The Shares have been duly authorized and, when issued and paid for in
accordance with the terms of the Transaction Documents, will be duly and validly issued, fully paid and nonassessable and free and clear of all Liens suffered or permitted by the Company, other than restrictions on transfer provided for in the
Transaction Documents or imposed by applicable securities laws, and shall not be subject to preemptive or similar rights. Assuming the accuracy of the representations and warranties of the Purchasers in this Agreement, the Shares will be issued in
compliance with all applicable federal and state securities laws. 
 (g) Capitalization. The number of shares and type of all
authorized, issued and outstanding capital stock, options and other securities of the Company (whether or not presently convertible into or exercisable or exchangeable for shares of capital stock of the Company) has been set forth in the SEC Reports
and has changed since the date set forth in the most recently filed of the SEC 

  
 8. 

 
Reports only to reflect stock option exercises and grants and warrant exercises and grants that have not, individually or in the aggregate, had a material affect on the issued and outstanding
capital stock, options and other securities of the Company. All of the outstanding shares of capital stock of the Company are duly authorized, validly issued, fully paid and non-assessable, have been issued in compliance in all material respects
with all applicable federal and state securities laws, and none of such outstanding shares was issued in violation of any preemptive rights or similar rights to subscribe for or purchase any capital stock of the Company. Except as set forth in the
SEC Reports: (i) no shares of the Company’s capital stock are subject to preemptive rights or any other similar rights or any Liens suffered or permitted by the Company; (ii) except for the Transaction Documents or as a result of the
performance by the Company of the Transaction Documents, there are no outstanding options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible into, or
exercisable or exchangeable for, any shares of capital stock of the Company, or contracts, commitments, understandings or arrangements by which the Company is or may become bound to issue additional shares of capital stock of the Company or options,
warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible into, or exercisable or exchangeable for, any shares of capital stock of the Company; (iii) there are no
outstanding debt securities, notes, credit agreements, credit facilities or other agreements, documents or instruments evidencing indebtedness of the Company or by which the Company is or may become bound; (iv) there are no financing statements
securing obligations in any material amounts, either singly or in the aggregate, filed in connection with the Company; (v) there are no agreements or arrangements under which the Company is obligated to register the sale of any of their
securities under the Securities Act (except the Registration Rights Agreement); (vi) there are no outstanding securities or instruments of the Company or which contain any redemption or similar provisions, and there are no contracts,
commitments, understandings or arrangements by which the Company is or may become bound to redeem a security of the Company; (vii) there are no securities or instruments containing anti-dilution or similar provisions that will be triggered by
the issuance of the Securities; (viii) the Company does not have any stock appreciation rights or “phantom stock” plans or agreements or any similar plan or agreement; and (ix) the Company has no liabilities or obligations
required to be disclosed in the SEC Reports (including, for purposes hereof, any liabilities that are required to be disclosed in a Form 10) but not so disclosed in the SEC Reports, other than those incurred in the ordinary course of the
Company’s businesses and which, individually or in the aggregate, do not or would not have a Material Adverse Effect. 
 (h) SEC
Reports. The Company has filed all reports, schedules, forms, statements and other documents required to be filed by it under the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for twelve (12) months preceding and
including the date hereof (or such shorter period as the Company was required by law or regulation to file such material), including without limitation, that certain Current Report on Form 8-K filed with the Commission on or before the date hereof
disclosing, among other things, the completion of the Reverse Merger Transaction and the Company ceasing to be a “shell company” as defined in Rule 12b-2 under the Exchange Act (the foregoing materials, including the exhibits thereto and
documents incorporated by reference therein, being collectively referred to herein as the “SEC Reports” and together with this Agreement, including the Disclosure Schedules hereto, the “Disclosure
Materials”), on a timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. As of the date hereof, the Company has no Knowledge of any event
occurring on or prior to the Closing Date (other than the transactions contemplated by the Transaction Documents) that requires the filing of a Current Report on Form 8-K after the Closing. 

(i) Financial Statements. The financial statements of the Company included in the SEC Reports comply in all material respects with
applicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing. Such financial 

  
 9. 

 
statements have been prepared in accordance with GAAP applied on a consistent basis during the periods involved, except as may be otherwise specified in such financial statements or the notes
thereto and except that unaudited financial statements may not contain all footnotes required by GAAP, and fairly present in all material respects the financial position of the Company and its consolidated Subsidiaries taken as a whole as of and for
the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, year-end audit adjustments. 

(j) Tax Matters. The Company (i) has prepared and filed all foreign, federal and state income and all other tax returns, reports
and declarations required by any jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to be due on such returns, reports and declarations,
except those being contested in good faith, with respect to which adequate reserves have been set aside on the books of the Company and (iii) has set aside on its books provisions reasonably adequate for the payment of all taxes for periods
subsequent to the periods to which such returns, reports or declarations apply, except where the failure to so pay or file or set aside provisions for any such tax, assessment, charge or return would not have a Material Adverse Effect. 

(k) Material Changes. Since the date of the latest financial statements included within the SEC Reports, except as specifically
disclosed in the SEC Reports, (i) there have been no events, occurrences or developments that have had or would reasonably be expected to have a Material Adverse Effect, (ii) the Company has not incurred any material liabilities
(contingent or otherwise) other than (A) trade payables, accrued expenses and other liabilities incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the
Company’s financial statements pursuant to GAAP or to be disclosed in filings made with the Commission, (iii) the Company has not materially altered its method of accounting or the manner in which it keeps its accounting books and records,
(iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock (other than in connection
with repurchases of unvested stock issued to employees of the Company), (v) the Company has not issued any equity securities to any officer, director or Affiliate, except Common Stock issued in the ordinary course pursuant to existing Company
stock option or stock purchase plans or executive and director corporate arrangements disclosed in the SEC Reports and (vi) there has not been any material change or amendment to, or any waiver of any material right under, any Material Contract
under which the Company or any of its assets is bound or subject. Except for the issuance of the Securities contemplated by this Agreement, no event, liability or development has occurred or exists with respect to the Company or its business,
properties, operations or financial condition that would be required to be disclosed by the Company under applicable securities laws at the time this representation is made that has not been publicly disclosed in the SEC Reports. 

(l) Environmental Matters. To the Company’s Knowledge, the Company (i) is not in violation of any statute, rule, regulation,
decision or order of any governmental agency or body or any court, domestic or foreign, relating to the use, disposal or release of hazardous or toxic substances or relating to the protection or restoration of the environment or human exposure to
hazardous or toxic substances (collectively, “Environmental Laws”), (ii) does not own or operate any real property contaminated with any substance that is in violation of any Environmental Laws, (iii) is not liable
for any off-site disposal or contamination pursuant to any Environmental Laws, and (iv) is not subject to any claim relating to any Environmental Laws; which violation, contamination, liability or claim has had or would have a Material Adverse
Effect; and there is no pending or, to the Company’s Knowledge, threatened investigation that might lead to such a claim. 
 (m)
Litigation. There is no Action which (i) adversely affects or challenges the legality, validity or enforceability of any of the Transaction Documents or the Securities, (ii) involves a 

  
 10. 

 
claim of violation of or liability under any federal, state, local or foreign laws governing the Company’s operations, including without limiting the generality of the foregoing, laws
regulating the protection of human health, including without limiting the generality of the foregoing, laws relating to the manufacture, processing, packaging, labeling, marketing, distribution, use, inspection, treatment, storage, disposal,
transport or handling of the Company’s products, and regulated or hazardous substances, as well as all authorizations, codes, decrees, demands or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits,
plans or regulations issued, entered, promulgated or approved thereunder, all as may be in effect from time to time and all successors, replacements and expansions thereof, (iii) involves injury to or death of any person arising from or
relating to any of the Company’s product or (iv) could, if there were an unfavorable decision, have a Material Adverse Effect. The Commission has not issued any stop order or other order suspending the effectiveness of any registration
statement filed by the Company under the Exchange Act or the Securities Act. 
 (n) Employment Matters. No material labor dispute
exists or, to the Company’s Knowledge, is imminent with respect to any of the employees of the Company which would have a Material Adverse Effect. None of the Company’s employees is a member of a union that relates to such employee’s
relationship with the Company, and the Company is not a party to a collective bargaining agreement, and the Company believes that its relationship with its employees is good. 

(o) Compliance. The Company (i) is not in default under or in violation of (and no event has occurred that has not been waived
that, with notice or lapse of time or both, would result in a default by the Company), nor has the Company received written notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreement or any
other Material Contract (whether or not such default or violation has been waived), (ii) is not in violation of any order of any court, arbitrator or governmental body having jurisdiction over the Company or its properties or assets and
(iii) is not and has not been in violation of, or in receipt of notice that it is in violation of, any statute, rule or regulation of any governmental authority applicable to the Company, including without limitation, all applicable rules and
regulations of the Food and Drug Administration (the “FDA”), and all applicable laws, statutes, ordinances, rules or regulations (including, without limitation, the Federal Food, Drug and Cosmetic Act of 1938, as amended and
similar foreign laws and regulations) enforced by the FDA or equivalent foreign authorities, except in each case as would not, individually or in the aggregate, have a Material Adverse Effect. 

(p) Regulatory Permits. The Company possesses all certificates, authorizations and permits issued by the appropriate federal, state,
local or foreign regulatory authorities necessary to conduct its business as described in the SEC Reports, including without limitation the FDA, except where the failure to possess such permits has not had and would not have a Material Adverse
Effect (“Material Permits”), and (i) the Company has not received any notice of proceedings relating to the revocation or modification of any such Material Permits and (ii) the Company has no Knowledge of any facts
or circumstances that the Company would reasonably expect to give rise to the revocation or modification of any Material Permits. 
 (q)
Title to Assets. The Company does not own any real property. The Company has good and marketable title to all tangible personal property owned by it which is material to the business of the Company, in each case free and clear of all Liens
except such as do not materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company and except for Liens for the payment of federal, state or other taxes for
which appropriate reserves have been made in accordance with GAAP and the payment of which is not delinquent or subject to penalties. Any real property and facilities held under lease by the Company are held by it under valid, subsisting and
enforceable leases with such exceptions as are not material and do not interfere with the use made of such property and buildings by the Company. 

  
 11. 

 (r) Intellectual Property. To the Company’s Knowledge, the Company or its
Subsidiaries owns, possesses, licenses or has other rights to use all foreign and domestic patents, patent applications, trade and service marks, trade and service mark registrations, trade names, copyrights, licenses, inventions, trade secrets,
technology and other proprietary rights and processes (collectively, the “Intellectual Property”) necessary for the conduct of its businesses as now conducted and which the failure to so own, possess, license or have other
rights to use would not have a Material Adverse Effect. Except where any such violations or infringements would not have a Material Adverse Effect, to the Company’s Knowledge (i) the Company’s or its Subsidiaries’ use of any such
Intellectual Property in the conduct of its business as presently conducted does not infringe upon the rights of any third parties; (ii) there is no infringement by third parties of any such Intellectual Property; (iii) there is no pending
or threatened Action challenging the Company’s rights in or to any such Intellectual Property; (iv) there is no pending or threatened Action challenging the validity or scope of any such Intellectual Property; and (v) there is no
pending or threatened Action that the Company infringes or otherwise violates any patent, trademark, copyright, trade secret or other proprietary rights of others. 

(s) Insurance. The Company is insured by insurers of recognized financial responsibility against such losses and risks and in such
amounts as the Company believes to be prudent in the businesses and locations in which the Company is engaged. The Company has not received any notice of cancellation of any such insurance, nor does the Company have any Knowledge that it will be
unable to renew its existing insurance coverage for the Company as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business without a significant increase in cost. 

(t) Transactions With Affiliates and Employees. None of the officers or directors of the Company and, to the Company’s Knowledge,
none of the employees of the Company, is presently a party to any transaction with the Company or to a presently contemplated transaction (other than for services as employees, officers and directors) that would be required to be disclosed pursuant
to Item 404 of Regulation S-K promulgated under the Securities Act, except as contemplated by the Transaction Documents or set forth in the SEC Reports. 

(u) Internal Accounting Controls. The Company’s certifying officers have evaluated the effectiveness of the disclosure controls
and procedures of the Company as of the end of the period covered by the most recently filed periodic report under the Exchange Act (such date, the “Evaluation Date”). The Company presented in its most recently filed periodic
report under the Exchange Act the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date. Since the Evaluation Date, there have been no changes in
the internal control over financial reporting (as such term is defined in the Exchange Act) of the Company that have adversely materially affected, or are reasonably likely to adversely materially affect, the internal control over financial
reporting of the Company. 
 (v) Sarbanes-Oxley; Disclosure Controls. The Company is in compliance in all material respects with all
of the provisions of the Sarbanes-Oxley Act of 2002 which are applicable to it. 
 (w) Certain Fees. Other than the Placement Agent,
no person or entity will have, as a result of the transactions contemplated by this Agreement, any valid right, interest or claim against or upon the Company or a Purchaser for any commission, fee or other compensation pursuant to any agreement,
arrangement or understanding entered into by or on behalf of the Company. The Company shall indemnify, pay, and hold each Purchaser harmless against, any liability, loss or expense (including, without limitation, attorneys’ fees and
out-of-pocket expenses) arising in connection with any such right, interest or claim. 

  
 12. 

 (x) Private Placement. Assuming the accuracy of the Purchasers’ representations and
warranties set forth in Section 3.2 of this Agreement (without giving effect to any materiality qualifiers therein) and the accuracy of the information disclosed by each Purchaser in the Accredited Investor Questionnaires delivered pursuant to
Section 2.2(b)(iv) and Section 5.2(d), no registration under the Securities Act is required for the offer and sale of the Securities by the Company to the Purchasers under the Transaction Documents. 

(y) Registration Rights. Other than each of the Purchasers, no Person has any right to cause the Company to effect the registration
under the Securities Act of any securities of the Company other than those securities which are currently registered on an effective registration statement on file with the Commission. 

(z) No Directed Selling Efforts or General Solicitation. Neither the Company nor any Person acting on its behalf has conducted any
“general solicitation” or “general advertising” (as those terms are used in Regulation D) in connection with the offer or sale of any of the Securities. 

(aa) No Integrated Offering. Assuming the accuracy of the Purchasers’ representations and warranties set forth in Section 3.2
(without giving effect to any materiality qualifiers therein), except as disclosed in the SEC Reports and except for the Future Financings, neither the Company nor any Person acting on its behalf has, directly or indirectly, at any time within the
past six (6) months, made any offers or sales of any Company security or solicited any offers to buy any security under circumstances that would (i) eliminate the availability of the exemption from registration under Regulation D
under the Securities Act in connection with the offer and sale by the Company of the Securities as contemplated hereby or (ii) cause the offering of the Securities pursuant to the Transaction Documents to be integrated with prior offerings by
the Company for purposes of any applicable law, regulation or shareholder approval provisions, including, without limitation, under the rules and regulations of any Trading Market on which any of the securities of the Company are listed or
designated. 
 (bb) Listing and Maintenance Requirements. The Company’s Common Stock is registered pursuant to
Section 12(b) or 12(g) of the Exchange Act, and the Company has taken no action designed to terminate the registration of the Common Stock under the Exchange Act nor has the Company received any notification that the Commission is contemplating
terminating such registration. 
 (cc) Investment Company. The Company is not required to be registered as, and is not an Affiliate
of, and immediately following the Closing will not be required to register as, an “investment company” within the meaning of the Investment Company Act of 1940, as amended. 

(dd) Application of Takeover Protections; Rights Agreements. The Company and its board of directors have taken all necessary action, if
any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or, except as disclosed in the SEC Reports, other similar anti-takeover provision under the
Company’s charter documents or the laws of the State of Nevada that is or could reasonably be expected to become applicable to any of the Purchasers as a result of the Purchasers and the Company fulfilling their obligations or exercising their
rights under the Transaction Documents, including, without limitation, the Company’s issuance of the Securities and the Purchasers’ ownership of the Securities. The Company has not adopted a stockholder rights plan or similar arrangement
relating to accumulations of beneficial ownership of Common Stock or a change in control of the Company. 
 (ee) Off Balance Sheet
Arrangements. There is no transaction, arrangement, or other relationship between the Company and an unconsolidated or other off balance sheet entity that is required to be disclosed by the Company in its SEC Reports (including, for purposes
hereof, any that are required to be disclosed in a Form 10) and is not so disclosed or that otherwise would have a Material Adverse Effect. 

  
 13. 

 (ff) Acknowledgment Regarding the Purchasers’ Purchase of Securities. The Company
acknowledges and agrees that each of the Purchasers is acting solely in the capacity of an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated thereby. The Company further acknowledges that no
Purchaser is acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with respect to the Transaction Documents and the transactions contemplated thereby and any advice given by any Purchaser or any of their respective
representatives or agents in connection with the Transaction Documents and the transactions contemplated thereby is merely incidental to the Purchasers’ purchase of the Securities. 

(gg) Foreign Corrupt Practices. Neither the Company, nor to the Company’s Knowledge, any agent or other person acting on behalf of
the Company, has: (i) directly or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreign or
domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by the Company (or made by any person acting on its behalf of
which the Company is aware) which is in violation of law or (iv) violated in any material respect any provision of the Foreign Corrupt Practices Act of 1977, as amended. 

(hh) No Additional Agreements. The Company does not have any agreement or understanding with any Purchaser with respect to the
transactions contemplated by the Transaction Documents other than as specified in the Transaction Documents. 
 3.2 Representations and
Warranties of the Purchasers. Each Purchaser hereby, for itself and for no other Purchaser, represents and warrants as of the date hereof and as of the Closing Date in the case of the Purchasers listed on Annex A hereto to the Company as
follows: 
 (a) Organization; Authority. Such Purchaser is an entity duly organized, validly existing and in good standing under the
laws of the jurisdiction of its organization with the requisite corporate, partnership, limited liability company or other similar power and authority to enter into and to consummate the transactions contemplated by the Transaction Documents to
which it is a party and otherwise to carry out its obligations hereunder and thereunder. The execution, delivery and performance by such Purchaser of the transactions contemplated by this Agreement have been duly authorized by all necessary
corporate or, if such Purchaser is not a corporation, such partnership, limited liability company or other applicable like action, on the part of such Purchaser. Each Transaction Document to which it is a party has been duly executed by such
Purchaser, and when delivered by such Purchaser in accordance with the terms hereof, will constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance with its terms, except as such enforceability may
be limited by applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies or by other equitable principles of general
application or insofar as indemnification and contribution provisions may be limited by applicable law. 
 (b) No Conflicts. The
execution, delivery and performance by such Purchaser of the Transaction Documents to which it is a party and the consummation by such Purchaser of the transactions contemplated hereby and thereby will not (i) result in a violation of the
organizational documents of such Purchaser, (ii) conflict with, or constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration
or cancellation of, any agreement, indenture or instrument to which such Purchaser is a party or (iii) result in 

  
 14. 

 
a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws) applicable to such Purchaser, except in the case of clauses (ii) and
(iii) above, for such conflicts, defaults, rights or violations which would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the ability of such Purchaser to perform its obligations hereunder.

 (c) Investment Intent. Such Purchaser understands that the Securities are “restricted securities” and have not been
registered under the Securities Act or any applicable state securities law and is acquiring the Securities as principal for its own account and not with a view to, or for distributing or reselling such Securities or any part thereof in violation of
the Securities Act or any applicable state securities laws, provided, however, that by making the representations herein, such Purchaser does not agree to hold any of the Securities for any minimum period of time and reserves the right,
subject to the provisions of this Agreement and the Registration Rights Agreement, at all times to sell or otherwise dispose of all or any part of such Securities pursuant to an effective registration statement under the Securities Act or under an
exemption from such registration and in compliance with applicable federal and state securities laws. Such Purchaser is acquiring the Securities hereunder in the ordinary course of its business. Such Purchaser does not presently have any agreement,
plan or understanding, directly or indirectly, with any Person to distribute or effect any distribution of any of the Securities (or any securities which are derivatives thereof) to or through any person or entity; such Purchaser is not a registered
broker-dealer under Section 15 of the Exchange Act or an entity engaged in a business that would require it to be so registered as a broker-dealer. 

(d) Purchaser Status. At the time such Purchaser was offered the Securities, it was, and at the date hereof it is, an “accredited
investor” as defined in Rule 501(a) under the Securities Act. 
 (e) General Solicitation. Such Purchaser is not purchasing the
Securities as a result of any advertisement, article, notice or other communication regarding the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented at any seminar or any other general
advertisement. 
 (f) Experience of Such Purchaser. Such Purchaser, either alone or together with its representatives, has such
knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Securities, and has so evaluated the merits and risks of such investment. Such
Purchaser is able to bear the economic risk of an investment in the Securities and, at the present time, is able to afford a complete loss of such investment. 

(g) Access to Information. Such Purchaser acknowledges that it has had the opportunity to review the Disclosure Materials and has been
afforded (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and conditions of the offering of the Securities and the merits and risks of
investing in the Securities; (ii) access to information about the Company and its respective financial condition, results of operations, business, properties, management and prospects sufficient to enable it to evaluate its investment; and
(iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed investment decision with respect to the investment. Neither such
inquiries nor any other investigation conducted by or on behalf of such Purchaser or its representatives or counsel shall modify, amend or affect such Purchaser’s right to rely on the truth, accuracy and completeness of the Disclosure Materials
and the Company’s representations and warranties contained in the Transaction Documents (as qualified by the Disclosure Materials). Such Purchaser has sought such accounting, legal and tax advice as it has considered necessary to make an
informed decision with respect to its acquisition of the Securities. 

  
 15. 

 (h) Certain Trading Activities. Other than with respect to the transactions contemplated
herein, since the time that such Purchaser was first contacted by the Company or any other Person regarding the transactions contemplated hereby, neither the Purchaser nor, to the knowledge of such Purchaser, any Affiliate of such Purchaser which
(i) had knowledge of the transactions contemplated hereby, (ii) has or shares discretion relating to such Purchaser’s investments or trading or information concerning such Purchaser’s investments, including in respect of the
Securities and (iii) is subject to such Purchaser’s review or input concerning such Affiliate’s investments or trading (collectively, “Trading Affiliates”) has directly or indirectly, nor has any Person
acting on behalf of or pursuant to any understanding with such Purchaser or Trading Affiliate, effected or agreed to effect any transactions in the securities of the Company (including, without limitation, any Short Sales involving the
Company’s securities). Notwithstanding the foregoing, in the case of a Purchaser and/or Trading Affiliate that is, individually or collectively, a multi-managed investment vehicle whereby separate portfolio managers manage separate portions of
such Purchaser’s or Trading Affiliate’s assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of such Purchaser’s or Trading Affiliate’s
assets, the representation set forth above shall apply only with respect to the portion of assets managed by the portfolio manager(s) that have knowledge about the financing transaction contemplated by this Agreement. Other than to other Persons
party to this Agreement, such Purchaser has maintained the confidentiality of all disclosures made to it in connection with the transactions contemplated hereby (including the existence and terms of such transactions). Notwithstanding the foregoing,
and except as otherwise provided in Section 4.12, no Purchaser makes any representation, warranty or covenant hereby that it will not engage in Short Sales in the securities of the Company after the effectiveness of the Registration Statement
as described in Section 4.12. 
 (i) Brokers and Finders. Other than the Placement Agent, no Person will have, as a result of
the transactions contemplated by this Agreement, any valid right, interest or claim against or upon the Company or any Purchaser for any commission, fee or other compensation pursuant to any agreement, arrangement or understanding entered into by or
on behalf of such Purchaser. 
 (j) Independent Investment Decision. Such Purchaser has independently evaluated the merits of its
decision to purchase Securities pursuant to the Transaction Documents, and such Purchaser confirms that it has not relied on the advice of any other Purchaser’s business and/or legal counsel in making such decision. Such Purchaser understands
that nothing in this Agreement or any other materials presented by or on behalf of the Company to the Purchaser in connection with the purchase of the Securities constitutes legal, tax or investment advice. Such Purchaser has consulted such legal,
tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase of the Securities. 

(k) Reliance on Exemptions. Such Purchaser understands that the Securities are being offered and sold to it in reliance on specific
exemptions from the registration requirements of United States federal and state securities laws and that the Company is relying in part upon the truth and accuracy of, and such Purchaser’s compliance with, the representations, warranties,
agreements, acknowledgements and understandings of such Purchaser set forth herein in order to determine the availability of such exemptions and the eligibility of such Purchaser to acquire the Securities. 

(l) No Governmental Review. Such Purchaser understands that no United States federal or state agency or any other government or
governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the Securities nor have such authorities passed upon or endorsed the merits of the offering of the
Securities. 

  
 16. 

 (m) Regulation M. Such Purchaser is aware that the anti-manipulation rules of
Regulation M under the Exchange Act may apply to sales of Common Stock and other activities with respect to the Common Stock by the Purchasers. 

(n) Residency. Such Purchaser’s principal executive offices are in the jurisdiction set forth immediately below such
Purchaser’s name on the applicable signature page attached hereto. 
 (o) Trading Market. Such Purchaser acknowledges that the
Securities are quoted over-the-counter, and that no securities issued by the Company are listed on a national securities exchange. 
 (p)
Shell Company. Such Purchaser acknowledges that the Company may be deemed to be a “shell company” as defined by the rules and regulations of the Commission. 

(q) Future Financings. Such Purchaser acknowledges that the Company intends to sell and issue securities, which may include shares of
Common Stock and/or securities exercisable for or convertible into Common Stock, in the aggregate amount of up to fifteen million dollars ($15,000,000) within one hundred eighty (180) days of the Closing Date in one or more financings (the
“Future Financings”). 
 The Company and each of the Purchasers acknowledge and agree that no party to this
Agreement has made or makes any representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in this Article III and the Transaction Documents. 

ARTICLE 4 
 OTHER
AGREEMENTS OF THE PARTIES 
 4.1 Transfer Restrictions. 

(a) Compliance with Laws. Notwithstanding any other provision of the Transaction Documents, each Purchaser covenants that the
Securities may be disposed of only pursuant to an effective registration statement under, and in compliance with the requirements of, the Securities Act, or pursuant to an available exemption from, or in a transaction not subject to, the
registration requirements of the Securities Act, and in compliance with any applicable state and federal securities laws. In connection with any transfer of the Securities other than (i) pursuant to an effective registration statement,
(ii) to the Company, (iii) to an Affiliate of a Purchaser, (iv) pursuant to Rule 144 (provided that the Purchaser provides the Company with reasonable assurances (in the form of seller and broker representation letters if
required) that the securities may be sold pursuant to such rule) or Rule 144A, (v) pursuant to Rule 144 without the requirement that the Company be in compliance with the current public information requirements of Rule 144 and
without other restriction following the applicable holding period or (vi) in connection with a bona fide pledge, the Company may require the transferor thereof to provide to the Company an opinion of counsel selected by the transferor and
reasonably acceptable to the Company, the form and substance of which opinion shall be reasonably satisfactory to the Company, to the effect that such transfer does not require registration of such transferred Securities under the Securities Act. As
a condition of transfer, any such transferee shall agree in writing to be bound by the terms of this Agreement and shall have the rights of a Purchaser under this Agreement and the Registration Rights Agreement. 

  
 17. 

 (b) Legends. Certificates evidencing the Securities shall bear any legend as required by
the “Blue Sky” laws of any state and a restrictive legend in substantially the following form until such time as they are not required under Section 4.1(c) (and a stock transfer order may be placed against transfer of the certificates
for the Securities): 
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OR
(B) AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL REASONABLY SATISFACTORY
TO THE COMPANY. 
 In addition, if any Purchaser is an Affiliate of the Company, certificates evidencing the Securities issued to such
Purchaser shall bear a customary “affiliates” legend. 
 (c) Removal of Legends. Subject to the Company’s right to
request an opinion of counsel as set forth in Section 4.1(a), the legend set forth in Section 4.1(b) above shall be removable and the Company shall issue or cause to be issued a certificate without such legend or any other legend (except
for any “affiliates” legend as set forth in Section 4.1(b)) to the holder of the applicable Shares upon which it is stamped or issue or cause to be issued to such holder by electronic delivery at the applicable balance account at The
Depository Trust Company (“DTC”) as provided in this Section 4.1(c), if (i) such Securities are registered for resale under the Securities Act (provided that, if the Purchaser is selling pursuant to the effective
registration statement registering the Securities for resale, the Purchaser agrees to only sell such Securities during such time that such registration statement is effective and not withdrawn or suspended, and only as permitted by such registration
statement), (ii) such Securities are sold or transferred in compliance with Rule 144 (if the transferor is not an Affiliate of the Company), including without limitation in compliance with the current public information requirements of Rule 144
if applicable to the Company at the time of such sale or transfer, and the holder and its broker have delivered customary documents reasonably requested by the Transfer Agent and/or Company Counsel in connection with such sale or transfer, or
(iii) such Securities are eligible for sale under Rule 144 without the requirement that the Company be in compliance with the current public information requirements of Rule 144 and without other restriction and Company Counsel has provided
written confirmation of such eligibility to the Transfer Agent. Any fees (with respect to the Transfer Agent, Company Counsel or otherwise) associated with the removal of such legend shall be borne by the Company. Following the Effective Date (as
defined in the Registration Rights Agreement), or at such other time as a legend is no longer required for certain Securities, the Company will no later than three (3) Trading Days following the delivery by a Purchaser to the Company or the
Transfer Agent (with concurrent notice and delivery of copies to the Company) of a legended certificate representing such Shares (endorsed or with stock powers attached, signatures guaranteed, and otherwise in form necessary to affect the reissuance
and/or transfer, and together with such other customary documents as the Transfer Agent and/or Company Counsel shall reasonably request), deliver or cause to be delivered to the transferee of such Purchaser or such Purchaser, as applicable, a
certificate representing such Securities that is free from all restrictive and other legends. The Company may not make any notation on its records or give instructions to the Transfer Agent that enlarge the restrictions on transfer set forth in this
Section 4.1. Certificates for Shares subject to legend removal hereunder shall be transmitted by the Transfer Agent to the Purchasers, as applicable, by crediting the account of the transferee’s Purchaser’s prime broker with DTC. 

(d) Irrevocable Transfer Agent Instructions. The Company shall issue irrevocable instructions to its Transfer Agent, and any subsequent
Transfer Agent, in the form of Exhibit C attached hereto (the “Irrevocable Transfer Agent Instructions”). The Company represents and warrants that no 

  
 18. 

 
instruction other than the Irrevocable Transfer Agent Instructions or instructions consistent therewith or otherwise contemplated hereby or thereby or by the other Transaction Documents or such
other documents as the Transfer Agent may request in connection with any such instructions will be given by the Company to its Transfer Agent in connection with this Agreement, and that the Securities shall otherwise be freely transferable on the
books and records of the Company as and to the extent provided in and subject to the terms of this Agreement, the other Transaction Documents and applicable law. 

(e) Acknowledgement. Each Purchaser hereunder acknowledges its primary responsibilities under the Securities Act and accordingly will
not sell or otherwise transfer the Shares or any interest therein without complying with the requirements of the Securities Act. While the Registration Statement remains effective, each Purchaser hereunder may sell the Shares in accordance with the
plan of distribution contained in the Registration Statement and, if it does so, it will comply therewith and with the related prospectus delivery requirements unless an exemption therefrom is available. Each Purchaser, severally and not jointly
with the other Purchasers, agrees that if it is notified by the Company in writing at any time that the Registration Statement registering the resale of the Shares is not effective or that the prospectus included in such Registration Statement no
longer complies with the requirements of Section 10 of the Securities Act, the Purchaser will refrain from selling such Shares until such time as the Purchaser is notified by the Company that such Registration Statement is effective or such
prospectus is compliant with Section 10 of the Securities Act, unless such Purchaser is able to, and does, sell such Shares pursuant to an available exemption from the registration requirements of Section 5 of the Securities Act. Each
Purchase acknowledges that the delivery of the Irrevocable Transfer Agent Instructions and any removal of any legends from certificates representing the Shares as set forth in this Section 4.1 is predicated on the Company’s reliance upon
the Purchaser’s acknowledgement in this Section 4.1(e). 
 (f) Buy-In. If the Company shall fail for any reason or for no
reason to issue to a Purchaser a certificate not bearing the legend set forth in Section 4.1(b) within three (3) Trading Days after receipt by the Company and the Transfer Agent of all documents necessary for the removal of the legend as
set forth in Section 4.1(c) (the “Deadline Date”) (such certificate, the “Unlegended Certificate”), then, in addition to all other remedies available to such Purchaser, if on or after the Trading
Day immediately following such three (3) Trading Day period, such Purchaser purchases (in an open market transaction or otherwise) shares of Common Stock to deliver in satisfaction of a sale by such Purchaser of the shares of Common Stock to be
represented by the Unlegended Certificate that such Purchaser anticipated receiving from the Company without any restrictive legend as a result of such Purchaser’s full compliance with Section 4.1(c) (a “Buy-In”),
then the Company shall, within three (3) Trading Days after such Purchaser’s request and in such Purchaser’s sole discretion, either (i) pay cash to the Purchaser in an amount equal to such Purchaser’s total purchase price
(including brokerage commissions, if any) for the shares of Common Stock so purchased (the “Buy-In Price”), at which point the Company’s obligation to deliver such certificate (and to issue such shares of Common Stock)
shall terminate, or (ii) promptly honor its obligation to deliver to such Purchaser a certificate or certificates representing such shares of Common Stock and pay cash to the Purchaser in an amount equal to the excess (if any) of the Buy-In
Price over the product of (a) such number of shares of Common Stock, times (b) the closing price of the Common Stock on the Deadline Date as reported by the Principal Trading Market. The Purchaser of shares of Common Stock shall provide
the Company written notice indicating the amounts payable to such Purchaser in respect of the Buy-In, together with applicable confirmations and other evidence reasonably requested by the Company. 

4.2 Acknowledgment of Dilution. The Company acknowledges that the issuance of the Securities may result in dilution of the outstanding
shares of Common Stock. The Company further acknowledges that its obligations under the Transaction Documents, including without limitation its obligation to issue the Shares pursuant to the Transaction Documents, are, subject to the terms and

  
 19. 

 
conditions expressly set forth in this Agreement, unconditional and absolute and not subject to any right of set off, counterclaim, delay or reduction, regardless of the effect of any such
dilution or any claim the Company may have against any Purchaser and regardless of the dilutive effect that such issuance may have on the ownership of the other stockholders of the Company. 

4.3 Antidilution Adjustment. As to each Purchaser, during the one hundred eighty (180) days following the Closing Date, if the
Company makes any issuance, sale, grant of any option or right to purchase or other disposition of any equity security or any equity-linked or related security (including, without limitation, any “equity security” as that term is defined
under Rule 405 promulgated under the Securities Act, any securities convertible into such equity securities, any preferred stock or any purchase rights) that is not an Excluded Security (as defined below), for a consideration per share that is less
than the Purchase Price (adjusted for stock splits, combinations, dividends and the like occurring after the date hereof) (such lesser price is referred to herein as the “Discounted Purchase Price”) (the foregoing, a
“Dilutive Issuance”), then promptly after such Dilutive Issuance, the Company shall issue to such Purchaser solely with respect to the Shares acquired pursuant to this Agreement or in connection with a Dilutive Issuance,
without the payment of additional consideration, a number of additional shares of Common Stock (the “Additional Shares”) equal to the result of subtracting (B) from (A), where (A) is the number of shares of Common
Stock the Purchaser would have received if the Purchaser had paid the Discounted Purchase Price instead of the Purchase Price (adjusted for stock splits, combinations, dividends and the like occurring after the Closing Date), and (B) is the
number of shares of Common Stock initially issued to the Purchaser at the Closing (adjusted for stock splits, combinations, dividends and the like occurring after the Closing Date) plus any shares of Common Stock previously received by the Purchaser
under this Section 4.3 in respect of a Dilutive Issuance (adjusted for stock splits, combinations, dividends and the like occurring after the Closing Date). Upon any issuance of Additional Shares hereunder, such Additional Shares shall be
included as Registrable Securities (as defined in the Registration Rights Agreement). 
 Excluded Securities include: (a) shares of
Common Stock issued upon exercise or conversion of any exercisable or convertible securities outstanding as of the date hereof; (b) shares of Common Stock or securities convertible into Common Stock issued to employees, officers or directors
of, or consultants or advisors to the Company or any subsidiary pursuant to stock purchase agreements, stock option plans or other arrangements that are approved by the Company’s board of directors; (c) shares of Common Stock or securities
convertible into Common Stock issued in connection with acquisitions, asset purchases, licenses, collaborations or strategic transactions involving the Company and other entities approved by the Company’s board of directors; provided that any
such issuance shall only be to a Person (or to the equityholders of a Person) and which is, itself or through its subsidiaries, an operating company or an owner of an asset in a business synergistic with the business of the Company and shall provide
to the Company additional benefits in addition to the investment of funds, but shall not include a transaction in which the Company is issuing securities primarily for the purpose of raising capital or to an entity whose primary business is
investing in securities and (d) shares of Common Stock or securities convertible or exercisable into Common Stock that the holders of a majority of the outstanding Shares elect in writing to deem Excluded Securities. 

4.4 Furnishing of Information. In order to enable the Purchasers to sell the Securities under Rule 144 of the Securities Act, for
a period of one year from the Closing Date, the Company shall use its commercially reasonable efforts to timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the
Company after the date hereof pursuant to the Exchange Act. During such one year period, if the Company is not required to file reports pursuant to such laws, it will prepare and furnish to the Purchasers and make publicly available in accordance
with Rule 144(c) such information as is required for the Purchasers to sell the Shares under Rule 144. 

  
 20. 

 4.5 Form D and Blue Sky. The Company agrees to timely file a Form D with respect
to the Securities as required under Regulation D and to provide a copy thereof to each Purchaser who requests a copy in writing promptly after such filing. The Company shall take such action as the Company shall reasonably determine is
necessary in order to qualify the Securities for sale to the Purchasers at the Closing pursuant to this Agreement under applicable securities or “Blue Sky” laws of the states of the United States (or to obtain an exemption from such
qualification), which, subject to the accuracy of the Company’s and the Purchaser’s representations and warranties set forth herein, shall consist of the submission of all filings and reports relating to the offer and sale of the
Securities pursuant to Rule 506 of Regulation D required under applicable securities or “Blue Sky” laws of the states of the United States following the Closing Date, and shall provide evidence of any such action so taken to the Purchasers
who request in writing such evidence. 
 4.6 No Integration. Except for the Future Financings, the Company shall not, and shall use
its commercially reasonable efforts to ensure that the Affiliates of the Company shall not, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that
will be integrated with the offer or sale of the Securities in a manner that would require the registration under the Securities Act of the sale of the Securities to the Purchasers, or that will be integrated with the offer or sale of the Securities
for purposes of the rules and regulations of any Trading Market such that it would require shareholder approval prior to the closing of such other transaction unless shareholder approval is obtained before the closing of such subsequent transaction.

 4.7 Securities Laws Disclosure; Publicity. By 9:00 a.m., New York City time, on the Trading Day immediately following the
execution of this Agreement, the Company shall issue a press release (the “Press Release”) disclosing all material terms of the transactions contemplated hereby. Within the time required by the Exchange Act, the Company will
file a Current Report on Form 8-K with the Commission describing the terms of the Transaction Documents (and including as exhibits to such Current Report on Form 8-K the material Transaction Documents (including, without limitation, this Agreement
and the Registration Rights Agreement)). Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser or an Affiliate of any Purchaser, or include the name of any Purchaser or an Affiliate of any Purchaser in any
press release or filing with the Commission (other than the Registration Statement) or any regulatory agency or Trading Market, without the prior written consent of such Purchaser, except (i) as required by federal securities law in connection
with (A) any registration statement contemplated by the Registration Rights Agreement and (B) the filing of final Transaction Documents (including signature pages thereto) with the Commission or (ii) to the extent such disclosure is
required by law, request of the Staff of the Commission or Trading Market regulations, in which case the Company shall provide the Purchasers with prior written notice of such disclosure permitted under this subclause (ii). From and after the
issuance of the Press Release, no Purchaser shall be in possession of any material, non-public information received from the Company or any of its respective officers, directors, employees or agents, that is not disclosed in the Press Release unless
a Purchaser shall have executed a written agreement regarding the confidentiality and use of such information. Each Purchaser, severally and not jointly with the other Purchasers, covenants that until such time as the transactions contemplated by
this Agreement are publicly disclosed by the Company as described in this Section 4.7, such Purchaser will maintain the confidentiality of all disclosures made to it in connection with such transactions (including the existence and terms of
such transactions). 
 4.8 Non-Public Information. Except with respect to the material terms and conditions of the transactions
contemplated by the Transaction Documents, the Company shall not and shall cause each of its officers, directors, employees and agents, not to, provide any Purchaser with any information the Company believes is material, non-public information
regarding the Company from and after the filing of the Press Release without the express written consent of such Purchaser, unless prior thereto such Purchaser shall have executed a written agreement regarding the confidentiality and use of such
information. 

  
 21. 

 4.9 Indemnification. 

(a) Indemnification of the Purchasers. In addition to the indemnity provided in the Registration Rights Agreement, subject to this
Section 4.9, the Company will indemnify and hold each Purchaser and its directors, officers, shareholders, members, partners, employees and agents (and any other Persons with a functionally equivalent role of a Person holding such titles
notwithstanding a lack of such title or any other title), each Person who controls such Purchaser (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders,
agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title) of such controlling Person (each, a “Purchaser
Party”) harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of
investigation that any such Purchaser Party may suffer or incur, as a result of or relating to third party claims against such Purchaser relating to any breach of any of the representations, warranties, covenants or agreements made by the Company in
this Agreement or in the other Transaction Documents, provided that such a claim for indemnification relating to any breach of any of the representations or warranties made by the Company in this Agreement is made within one (1) year
from the Closing. The Company will not be liable to any Purchaser Party under this Agreement to the extent, but only to the extent that a loss, claim, damage or liability is attributable to any Purchaser Party’s breach of any of the
representations, warranties, covenants or agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents. 

(b) Conduct of Indemnification Proceedings. Promptly after receipt by any Person (the “Indemnified
Person”) of notice of any demand, claim or circumstances which would or might give rise to a claim or the commencement of any action, proceeding or investigation in respect of which indemnity may be sought pursuant to
Section 4.9(a), such Indemnified Person shall promptly notify the Company in writing and the Company shall have the right to assume the defense thereof, including the employment of counsel reasonably satisfactory to such Indemnified Person and
the assumption of the payment of all fees and expenses; provided, however, that the failure of any Indemnified Person so to notify the Company shall not relieve the Company of its obligations hereunder except to the extent that the Company is
actually and materially prejudiced by such failure to notify. In any such proceeding, any Indemnified Person shall have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the expense of such Indemnified Person
unless: (i) the Company and the Indemnified Person shall have mutually agreed to the retention of such counsel; (ii) the Company shall have failed promptly to assume the defense of such proceeding and to employ counsel reasonably
satisfactory to such Indemnified Person in such proceeding; or (iii) in the reasonable judgment of counsel to such Indemnified Person and counsel to the Company, representation of both parties by the same counsel would be inappropriate due to
actual or potential differing interests between them, in which case the Company shall be responsible for the reasonable fees and expenses of no more than one such separate counsel. The Company shall not be liable for any settlement of any proceeding
effected without its written consent, which consent shall not be unreasonably withheld, delayed or conditioned. Without the prior written consent of the Indemnified Person, which consent shall not be unreasonably withheld, delayed or conditioned,
the Company shall not effect any settlement of any pending or threatened proceeding in respect of which any Indemnified Person is a party, unless such settlement includes an unconditional release of such Indemnified Person from all liability arising
out of such Proceeding. 
 4.10 Listing of Securities. In the time and manner required by the Principal Trading Market, the Company
shall prepare and file with such Trading Market any additional shares listing application 

  
 22. 

 
that may be required by such Trading Market covering all of the Shares and shall use its commercially reasonable efforts to take all steps necessary to maintain, so long as any other shares of
Common Stock shall be so listed, such listing. 
 4.11 Use of Proceeds. The Company intends to use the net proceeds from the sale of
the Securities hereunder for working capital and general corporate purposes. 
 4.12 Dispositions and Confidentiality After The Date
Hereof. Each Purchaser shall not, and shall cause its Trading Affiliates not to, prior to the effectiveness of the Registration Statement: (a) sell, offer to sell, solicit offers to buy, dispose of, loan, pledge or grant any right with
respect to (collectively, a “Disposition”) the Securities; or (b) engage in any hedging or other transaction which is designed or could reasonably be expected to lead to or result in a Disposition of the Securities by
such Purchaser or a Trading Affiliate, except, in each case, for Dispositions pursuant to an available exemption from, or in a transaction not subject to, the registration requirements of the Securities Act, and in compliance with any applicable
state and federal securities laws. In addition, the Purchaser agrees that for so long as it owns any Common Stock, it will not enter into any Short Sale of Shares executed at a time when the Purchaser has no equivalent offsetting long position in
the Common Stock. For purposes of determining whether the Purchaser has an equivalent offsetting long position in the Common Stock, shares that the Purchaser is entitled to receive within sixty (60) days (whether pursuant to contract or upon
conversion or exercise of convertible securities) will be included as if held long by the Purchaser. Such Purchaser covenants that neither it nor any Person acting on its behalf or pursuant to any understanding with it will engage in any
transactions in the Company’s securities (including, without limitation, any Short Sales involving the Company’s securities) during the period from the date hereof until the earlier of such time as (i) the transactions contemplated by
this Agreement are first publicly announced as described in Section 4.7 or (ii) this Agreement is terminated in full pursuant to Section 6.17. Notwithstanding the foregoing, in the case of a Purchaser that is a multi-managed
investment vehicle whereby separate portfolio managers manage separate portions of such Purchaser’s assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of
such Purchaser’s assets, the representation set forth above shall apply only with respect to the portion of assets managed by the portfolio manager that have knowledge about the financing transaction contemplated by this Agreement. Each
Purchaser understands and acknowledges, severally and not jointly with any other Purchaser, that the Commission currently takes the position that covering a short position established prior to effectiveness of a resale registration statement with
shares included in such registration statement would be a violation of Section 5 of the Securities Act, as set forth in Division of Corporation Financing Compliance and Disclosure Interpretation 239.10 regarding short selling. 

ARTICLE 5 
 CONDITIONS
PRECEDENT TO CLOSING 
 5.1 Conditions Precedent to the Obligations of the Purchasers to Purchase Securities at the Closing. The
obligation of each Purchaser listed on Annex A hereto to acquire Securities at the Closing is subject to the fulfillment to such Purchaser’s satisfaction, on or prior to the Closing Date, of each of the following conditions, any of which
may be waived by such Purchaser (as to itself only): 
 (a) Representations and Warranties. The representations and warranties of the
Company contained herein shall be true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and warranties shall be true and correct in all
respects) as of the date when made and as of the Closing Date, as though made on and as of such date, except for such representations and warranties that speak as of a different specified date. 

  
 23. 

 (b) Performance. The Company shall have performed, satisfied and complied in all material
respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing. 

(c) No Injunction. No statute, rule, regulation, executive order, decree, ruling or injunction shall have been enacted, entered,
promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction Documents. 

(d) Consents. The Company shall have obtained in a timely fashion any and all consents, permits, approvals, registrations and waivers
necessary for consummation of the purchase and sale of the Securities at the Closing (including all Required Approvals, except for those set forth in clauses (i), (ii), (iii) and (v) of Section 3.1(e), which may be obtained after the
Closing), all of which shall be and remain so long as necessary in full force and effect. 
 (e) No Suspensions of Trading in Common
Stock. The Common Stock shall not have been suspended, as of the Closing Date, by the Commission. 
 (f) Company
Deliverables. The Company shall have delivered the Company Deliverables in accordance with Section 2.2(a). 
 (g) Lock-Up
Agreements. The officers and directors of the Company and certain stockholders of record of the Company shall have delivered lock-up agreements in the form attached hereto as Exhibit F. 

(h) Completion of the Reverse Merger Transaction. The Reverse Merger Transaction shall have been completed. 

(i) Termination. This Agreement shall not have been terminated as to such Purchaser in accordance with Section 6.17 herein. 

(j) Minimum Raise. The Company shall have raised gross proceeds of at least twenty million dollars ($20,000,000) pursuant to the sale
of Shares under this Agreement and, thereupon, a certain License Agreement dated as of October 10, 2013 as amended with Nerviano Medical Sciences S.r.l. shall be effective. 

5.2 Conditions Precedent to the Obligations of the Company to sell Securities at the Closing. The Company’s obligation to sell and
issue the Securities to each Purchaser listed on Annex A hereto at the Closing is subject to the fulfillment to the satisfaction of the Company on or prior to the Closing Date of the following conditions, any of which may be waived by the
Company: 
 (a) Representations and Warranties. The representations and warranties made by such Purchaser in Section 3.2 hereof
shall be true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and warranties shall be true and correct in all respects) as of the date
when made, and as of the Closing Date as though made on and as of such date, except for representations and warranties that speak as of a different specified date. 

(b) Performance. Such Purchaser shall have performed, satisfied and complied in all material respects with all covenants, agreements
and conditions required by the Transaction Documents to be performed, satisfied or complied with by such Purchaser at or prior to the Closing Date. 

  
 24. 

 (c) No Injunction. No statute, rule, regulation, executive order, decree, ruling or
injunction shall have been enacted, entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction Documents. 

(d) Purchaser Deliverables. Such Purchaser shall have delivered its Purchaser Deliverables in accordance with Section 2.2(b). 

(e) Completion of the Reverse Merger Transaction. The Reverse Merger Transaction shall have been completed. 

(f) Termination. This Agreement shall not have been terminated as to such Purchaser in accordance with Section 6.17 herein. 

ARTICLE 6 
 MISCELLANEOUS

 6.1 Fees and Expenses. Except as expressly set forth in the Transaction Documents to the contrary, the Company and the
Purchasers shall each pay the fees and expenses of their respective advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party in connection with the negotiation, preparation, execution, delivery and
performance of this Agreement. The Company shall pay all Transfer Agent fees, stamp taxes and other taxes and duties levied in connection with the sale and issuance of the Securities to the Purchasers. 

6.2 Entire Agreement. The Transaction Documents, together with the exhibits and schedules thereto, contain the entire understanding of
the parties with respect to the subject matter thereof and supersede all prior agreements, understandings, discussions and representations, oral or written, with respect to such matters, which the parties acknowledge have been merged into such
documents, exhibits and schedules. At or after the Closing, and without further consideration, the Company and the Purchasers will execute and deliver to the other such further documents as may be reasonably requested in order to give practical
effect to the intention of the parties under the Transaction Documents. 
 6.3 Notices. Any and all notices or other communications
or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is delivered via facsimile (provided the
sender receives a machine-generated confirmation of successful transmission) at the facsimile number specified in this Section prior to 5:00 p.m., New York City time, on a Trading Day, (b) the next Trading Day after the date of transmission, if
such notice or communication is delivered via facsimile (provided the sender receives a machine-generated confirmation of successful transmission) at the facsimile number specified in this Section on a day that is not a Trading Day or later than
5:00 p.m., New York City time, on any Trading Day, (c) the Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service with next day delivery specified, or (d) upon actual receipt by the party
to whom such notice is required to be given. The address for such notices and communications shall be as follows: 
  

					
	 If to the Company:
	  	Ignyta, Inc.	  	
		  	11095 Flintkote Avenue, Suite D	  	
		  	San Diego, California 92121	  	
		  	Telephone No.: (858)255-5960	  	
		  	Facsimile No.: (858) 255-5959	  	
		  	Attention: Chief Executive Officer	  	

  
 25. 

					
	With a copy to:	  	Morrison & Foerster LLP	  	
		  	12531 High Bluff Drive, Suite 100	  	
		  	San Diego, California 92130	  	
		  	Telephone No.: (858) 720-5100	  	
		  	Facsimile No.: (650) 720-5125	  	
		  	Attention: Jay de Groot	  	
		
	If to a Purchaser:	  	To the address set forth under such Purchaser’s name on its signature page hereof;

 or such other address as may be designated in writing hereafter, in the same manner, by such Person. 

6.4 Amendments; Waivers; No Additional Consideration. No provision of this Agreement may be waived or amended except in a written
instrument signed, in the case of an amendment, by the Company and the Purchasers holding or having the right to acquire at least a majority of the Shares to be purchased at the Closing or then outstanding or, in the case of a waiver, by the party
against whom enforcement of any such waiver is sought. No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default
or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right hereunder in any manner impair the exercise of any such right. No consideration shall be offered or paid to
any Purchaser to amend or consent to a waiver or modification of any provision of any Transaction Document unless the same consideration is also offered to all Purchasers who then hold Securities. 

6.5 Construction. The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to
limit or affect any of the provisions hereof. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against any party. This
Agreement shall be construed as if drafted jointly by the parties, and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of the authorship of any provisions of this Agreement or any of the Transaction
Documents. 
 6.6 Successors and Assigns. The provisions of this Agreement shall inure to the benefit of and be binding upon the
parties and their successors and permitted assigns. This Agreement, or any rights or obligations hereunder, may not be assigned by the Company without the prior written consent of the Purchasers (other than by merger or consolidation or to an entity
which acquires the Company, including by way of acquiring all or substantially all of the Company’s assets). Any Purchaser may assign its rights hereunder in whole or in part to any Person to whom such Purchaser assigns or transfers any
Securities in compliance with the Transaction Documents and applicable law, provided such transferee shall agree in writing to be bound, with respect to the transferred Securities, by the terms and conditions of this Agreement that apply to the
“Purchasers”. 
 6.7 No Third-Party Beneficiaries. This Agreement is intended for the benefit of the parties
hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 

6.8 Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be
governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each 

  
 26. 

 
party agrees that all Proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought
against a party hereto or its respective Affiliates, employees or agents) shall be commenced exclusively in the New York Courts. Each party hereto hereby irrevocably submits to the exclusive jurisdiction of the New York Courts for the adjudication
of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to
assert in any Proceeding, any claim that it is not personally subject to the jurisdiction of any such New York Court, or that such Proceeding has been commenced in an improper or inconvenient forum. Each party hereto hereby irrevocably waives
personal service of process and consents to process being served in any such Proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices
to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by
law. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED
HEREBY. 
 6.9 Survival. The representations and warranties contained herein shall survive the Closing and the delivery of the
Securities for a period of one (1) year from the Closing Date. The agreements and covenants contained herein shall survive for the applicable statute of limitations. 

6.10 Execution. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one
and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that the parties need not sign the same counterpart. In the event that any signature is
delivered by facsimile transmission, or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with
the same force and effect as if such facsimile or “.pdf” signature page were an original thereof. 
 6.11
Severability. If any provision of this Agreement is held to be invalid or unenforceable in any respect, the validity and enforceability of the remaining terms and provisions of this Agreement shall not in any way be affected or impaired thereby
and the parties will attempt to agree upon a valid and enforceable provision that is a reasonable substitute therefor and achieves that same or substantially the same effect or result, and upon so agreeing, shall incorporate such substitute
provision in this Agreement. 
 6.12 Replacement of Securities. If any certificate or instrument evidencing any Securities is
mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of
evidence reasonably satisfactory to the Company and the Transfer Agent of such loss, theft or destruction and the execution by the holder thereof of a customary lost certificate affidavit of that fact and an agreement to indemnify and hold harmless
the Company and the Transfer Agent for any losses in connection therewith or, if required by the Transfer Agent, a bond in such form and amount as is required by the Transfer Agent. The applicants for a new certificate or instrument under such
circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Securities. If a replacement certificate or instrument evidencing any Securities is requested due to a mutilation thereof, the Company may
require delivery of such mutilated certificate or instrument as a condition precedent to any issuance of a replacement. 

  
 27. 

 6.13 Remedies. In addition to being entitled to exercise all rights provided herein or
granted by law, including recovery of damages, each of the Purchasers and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages may not be adequate compensation for any loss
incurred by reason of any breach of obligations described in the foregoing sentence and hereby agree to waive in any action for specific performance of any such obligation (other than in connection with any action for a temporary restraining order)
the defense that a remedy at law would be adequate. 
 6.14 Payment Set Aside. To the extent that the Company makes a payment or
payments to any Purchaser pursuant to any Transaction Document or a Purchaser enforces or exercises its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated,
declared to be fraudulent or preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other Person under any law (including, without limitation, any
bankruptcy law, state or federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as
if such payment had not been made or such enforcement or setoff had not occurred. 
 6.15 Adjustments in Share Numbers and Prices. In
the event of any stock split, subdivision, dividend or distribution payable in shares of Common Stock (or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly shares of Common Stock),
combination or other similar recapitalization or event occurring after the date hereof, each reference in any Transaction Document to a number of shares or a price per share shall be deemed to be amended to appropriately account for such event. 

6.16 Independent Nature of the Purchasers’ Obligations and Rights. The obligations of each Purchaser under any Transaction
Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance of the obligations of any other Purchaser under any Transaction Document. The decision of each
Purchaser to purchase Securities pursuant to the Transaction Documents has been made by such Purchaser independently of any other Purchaser and independently of any information, materials, statements or opinions as to the business, affairs,
operations, assets, properties, liabilities, results of operations, condition (financial or otherwise) or prospects of the Company which may have been made or given by any other Purchaser or by any agent or employee of any other Purchaser, and no
Purchaser and any of its agents or employees shall have any liability to any other Purchaser (or any other Person) relating to or arising from any such information, materials, statement or opinions. Nothing contained herein or in any other
Transaction Document, and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed to constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the
Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by the Transaction Documents. Each Purchaser acknowledges that no other Purchaser has acted as agent for such Purchaser in
connection with making its investment hereunder and that no Purchaser will be acting as agent of such Purchaser in connection with monitoring its investment in the Securities or enforcing its rights under the Transaction Documents. Each Purchaser
shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser to be joined as
an additional party in any proceeding for such purpose. The Company acknowledges that each of the Purchasers has been provided with the same Transaction Documents for the purpose of closing a transaction with multiple Purchasers and not because it
was required or requested to do so by any Purchaser. The Company’s obligations to each Purchaser under this Agreement and the other Transaction Documents are identical to its obligations to each other Purchaser other than such differences
resulting solely from the number of Securities purchased by such Purchaser. 

  
 28. 

 6.17 Termination. This Agreement may be terminated and the sale and purchase of the Shares
abandoned at any time prior to the Closing by either the Company or any Purchaser listed on Annex A hereto (with respect to itself only), upon written notice to the other, if the Closing has not been consummated on or prior to 5:00 p.m., New
York City time, on the Outside Date; provided, however, that the right to terminate this Agreement under this Section 6.17 shall not be available to any Person whose failure to comply with its obligations under this Agreement has been
the cause of or resulted in the failure of the Closing to occur on or before such time. Nothing in this Section 6.17 shall be deemed to release any party from any liability for any breach by such party of the terms and provisions of this
Agreement or the other Transaction Documents or to impair the right of any party to compel specific performance by any other party of its obligations under this Agreement or the other Transaction Documents. In the event of a termination pursuant to
this Section, the Company shall promptly notify all non-terminating Purchasers. Upon a termination in accordance with this Section, the Company and the terminating Purchaser(s) shall not have any further obligation or liability (including arising
from such termination) to the other, and no Purchaser will have any liability to any other Purchaser under the Transaction Documents as a result therefrom. 

6.18 Waiver of Conflicts. Each Purchaser acknowledges that: (a) it has read this Agreement; (b) it has been represented in
the preparation, negotiation and execution of this Agreement by legal counsel of its own choice or has voluntarily declined to seek such counsel; and (c) it understands the terms and consequences of this Agreement and is fully aware of the
legal and binding effect of this Agreement. Each Purchaser understands that the Company has been represented in the preparation, negotiation and execution of this Agreement by Morrison & Foerster LLP, Company Counsel, and that
Morrison & Foerster LLP has not represented any Purchaser or any stockholder, director or employee of the Company in the preparation, negotiation and execution of this Agreement. Each Purchaser acknowledges that Morrison & Foerster
LLP may have in the past represented and may now or may in the future represent one or more Purchasers or their Affiliates in matters unrelated to the transactions contemplated by this Agreement, including the representation of such Purchasers or
their Affiliates in matters of a nature similar to those contemplated by this Agreement. The Company and each Purchaser hereby acknowledge that they have has had an opportunity to ask for and have obtained information relevant to such
representation, including disclosure of the reasonably foreseeable adverse consequences of such representation, and hereby waives any conflict arising out of such representation with respect to the matters contemplated by this Agreement. 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

[SIGNATURE PAGES FOR PURCHASERS FOLLOW] 

  
 29. 

 IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to
be duly executed by their respective authorized signatories as of the date first indicated above. 
  

			
	IGNYTA, INC.
		
	By:	 	  

	Name:	 	Jonathan Lim
	Title:	 	President and Chief Executive Officer

 OMNIBUS SIGNATURE PAGE TO SECURITIES PURCHASE AGREEMENT AND 

REGISTRATION RIGHTS AGREEMENT OF IGNYTA, INC. 

IN WITNESS WHEREOF, the undersigned Purchaser hereby executes, delivers, joins in and agrees to be bound by (i) (A) the
Securities Purchase Agreement by and among Ignyta, Inc., a Nevada corporation, and the Purchasers (as defined therein) to which this Omnibus Signature Page is attached, as a Purchaser thereunder, and (B) the Registration Rights Agreement by and
among the Company and the Purchasers (as defined therein), attached to the Securities Purchase Agreement, as a Purchaser thereunder, which, together with all counterparts of such agreements and signature pages of other parties to such agreements,
shall constitute one and the same document in accordance with the terms of such agreements, and (ii) elects to purchase the number of Shares set forth below pursuant to the Securities Purchase Agreement referenced above. 

 

			
	NAME OF PURCHASER:
                                        

		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	Aggregate Purchase Price (Subscription Amount):
	$                    
	
	Number of Shares to be Acquired:                             
	
	Tax ID No.:                         
	
	Address for Notice:
	
	  

	  

	
	Telephone No.:
                                         
                   
	
	Facsimile No.:
                                         
                   
	
	Attention:
                                         
                           

 

			
	 Delivery Instructions:

(if different than above)
  

c/o
                                         
                                         
                  
	 	
		
	 Street:
                                         
                                         
              
	 	
		
	 City/State/Zip:
                                         
                                        

	 	
		
	 Attention:
                                         
                                         
       
	 	
		
	 Telephone No.:
                                         
                                        

	 	

 ANNEX A: Schedule of Purchasers 

EXHIBITS: 
  

					
	A:	  	Form of Registration Rights Agreement	  	
	B-1:	  	Accredited Investor Questionnaire	  	
	B-2:	  	Stock Certificate Questionnaire	  	
	C:	  	Irrevocable Transfer Agent Instructions	  	
	D:	  	Form of Secretary’s Certificate	  	
	E:	  	Form of Compliance Certificate	  	
	F:	  	Form of Lock-Up Agreement	  	

 ANNEX A 

SCHEDULE OF PURCHASERS 
  

									
	 Purchasers
	  	Number of
Shares Purchased	 	  	Aggregate Purchase Price
(Subscription Amount)	 
	 1798 Fundamental Strategies Master Fund Ltd.
	  	 	665,000	  	  	$	3,990,000.00	  
	 2B LLC
	  	 	83,333	  	  	$	499,998.00	  
	 667, L.P. (Account #1)
	  	 	39,167	  	  	$	235,002.00	  
	 667, L.P. (Account #2)
	  	 	27,572	  	  	$	165,432.00	  
	 Alan G. Hassenfeld 1998 Revocable Trust Dtd 4/28/98
	  	 	41,700	  	  	$	250,200.00	  
	 Arbco Partners, LP
	  	 	16,667	  	  	$	100,002.00	  
	 Armistice Capital Master Fund Ltd.
	  	 	500,000	  	  	$	3,000,000.00	  
	 Baker Brothers Life Sciences, L.P.
	  	 	516,561	  	  	$	3,099,366.00	  
	 BioBrit, LLC
	  	 	33,333	  	  	$	199,998.00	  
	 Boxer Capital, LLC
	  	 	544,667	  	  	$	3,268,002.00	  
	 Brian Paul Horton 1998 Grantors Trust
	  	 	16,667	  	  	$	100,002.00	  
	 Broadfin Healthcare Master Fund, LTD
	  	 	416,700	  	  	$	2,500,200.00	  
	 Capital Ventures International
	  	 	41,600	  	  	$	249,600.00	  
	 Alexander Casdin
	  	 	50,000	  	  	$	300,000.00	  
	 Casdin Partners Master Fund, LP
	  	 	50,000	  	  	$	300,000.00	  
	 Eric Caslow
	  	 	16,667	  	  	$	100,002.00	  
	 City Hill Venture Partners I, LLC
	  	 	333,334	  	  	$	2,000,004.00	  
	 DAFNA Lifescience LTD
	  	 	27,000	  	  	$	162,000.00	  
	 DAFNA Lifescience Market Neutral LTD
	  	 	5,700	  	  	$	34,200.00	  
	 DAFNA Lifescience Select LTD
	  	 	50,700	  	  	$	304,200.00	  
	 Del Mar Master Fund, Ltd.
	  	 	166,666	  	  	$	999,996.00	  
	 Dinver, LLC
	  	 	25,000	  	  	$	150,000.00	  
	 Empery Asset Master, Ltd
	  	 	41,600	  	  	$	249,600.00	  
	 Robert S. Finkelstein
	  	 	20,000	  	  	$	120,000.00	  
	 Foresite Capital Fund I, L.P.
	  	 	500,000	  	  	$	3,000,000.00	  
	 Fourth Avenue Capital Partners LP
	  	 	171,667	  	  	$	1,030,002.00	  
	 Colby Harlow
	  	 	16,667	  	  	$	100,002.00	  
	 HFR HE Sphera Global Healthcare Master Trust
	  	 	12,034	  	  	$	72,204.00	  
	 Independence Capital Select Health Care Fund, L.P.
	  	 	8,400	  	  	$	50,400.00	  
	 Kevin A. Wechter Irrevocable Trust
	  	 	16,667	  	  	$	100,002.00	  
	 KKH Family Limited Partnership
	  	 	16,667	  	  	$	100,002.00	  
	 Devraj Lahiri
	  	 	8,340	  	  	$	50,040.00	  
	 LSM Capital Inc.
	  	 	85,000	  	  	$	510,000.00	  
	 Thomas Malley
	  	 	41,600	  	  	$	249,600.00	  
	 Andrew McDonald
	  	 	83,333	  	  	$	499,998.00	  
	 Merlin Nexus IV, LP
	  	 	400,000	  	  	$	2,400,000.00	  
	 Monashee Investment Management LLC
	  	 	100,000	  	  	$	600,000.00	  
	 MVA Investors, LLC
	  	 	83,333	  	  	$	499,998.00	  
	 David Odmark
	  	 	30,000	  	  	$	180,000.00	  
	 Pacific Equity Ventures, L.P.
	  	 	16,667	  	  	$	100,002.00	  
	 Harkishan B. Parekh
	  	 	29,167	  	  	$	175,002.00	  
	 Christopher Reyes
	  	 	8,333	  	  	$	49,998.00	  

									
	 Yehuda M. Rice
	  	 	83,333	  	  	$	499,998.00	  
	 Robert A. Fink & Jessica K. Fink Family Trust
	  	 	16,667	  	  	$	100,002.00	  
	 Abhijit Roy
	  	 	15,000	  	  	$	90,000.00	  
	 Sabby Healthcare Volatility Master Fund, Ltd.
	  	 	550,000	  	  	$	3,300,000.00	  
	 Jay B. Silverman
	  	 	16,667	  	  	$	100,002.00	  
	 Sphera Global Healthcare Master Fund
	  	 	192,966	  	  	$	1,157,796.00	  
	 David J. Strupp, Jr.
	  	 	8,333	  	  	$	49,998.00	  
	 Three Arch Opportunity Fund LP
	  	 	249,667	  	  	$	1,498,002.00	  
	 venBio Select Fund LLC
	  	 	416,700	  	  	$	2,500,200.00	  
	 Visium Balanced Master Fund, Ltd.
	  	 	833,300	  	  	$	4,999,800.00	  
		  	  
	  
	 	  	  
	  
	 
	 Total
	  	 	7,740,142	  	  	$	46,440,852.00	  

 EXHIBIT A 

FORM OF REGISTRATION RIGHTS AGREEMENT 

 INSTRUCTION SHEET 

(TO BE READ IN CONJUNCTION WITH THE ENTIRE SECURITIES PURCHASE 

AGREEMENT AND REGISTRATION RIGHTS AGREEMENT) 
  

	A.	Complete the following items in the Securities Purchase Agreement and/or Registration Rights Agreement: 

  

	 	1.	Provide the information regarding the Purchaser requested on the signature pages. The Securities Purchase Agreement and the Registration Rights Agreement (omnibus signature page) must be executed by an individual
authorized to bind the Purchaser. 

  

	 	2.	Exhibit B-1 – Accredited Investor Questionnaire: 

 Provide the information requested by the
Accredited Investor Questionnaire 
  

	 	3.	Exhibit B-2 Stock Certificate Questionnaire: 

 Provide the information requested by the Stock
Certificate Questionnaire 
  

	 	4.	Annex B to the Registration Rights Agreement — Selling Securityholder Notice and Questionnaire 

Provide the information requested by the Selling Securityholder Notice and Questionnaire 

 

	 	5.	Return the signed Securities Purchase Agreement and Registration Rights Agreement (omnibus signature page) and the signed and completed questionnaires referenced in 2, 3 and 4 above to: 

Vlad Ivanov 
 Ladenburg
Thalmann & Co. Inc 
 570 Lexington Avenue, 12th Floor 

New York, NY 10022 
 Tel:
(212) 409-2045 
 Fax: (718) 986-8496 

Email: vivanov@ladenburg.com 
  

	B.	Instructions regarding the transfer of funds for the purchase of the Securities will be provided separately. 

 EXHIBIT B-1 

ACCREDITED INVESTOR QUESTIONNAIRE 

(ALL INFORMATION WILL BE TREATED CONFIDENTIALLY) 

To: Ignyta, Inc. 
 This Investor
Questionnaire (“Questionnaire”) must be completed by each potential investor in connection with the offer and sale of the shares of the common stock, par value $0.00001 per share (collectively, the
“Securities”), of Ignyta, Inc., a Nevada corporation (the “Corporation”). The Securities are being offered and sold by the Corporation without registration under the Securities Act of 1933, as amended
(the “Act”), or the securities laws of any state or other jurisdiction, in reliance on the exemptions contained in Section 4(a)(2) of the Act and on Regulation D promulgated thereunder and in reliance on similar
exemptions under applicable state laws. The Corporation must determine that a potential investor meets certain suitability requirements before offering or selling Securities to such investor. The purpose of this Questionnaire is to assure the
Corporation that each investor will meet the applicable suitability requirements. The information supplied by you will be used in determining whether you meet such criteria, and reliance upon the private offering exemptions from registration is
based in part on the information herein supplied. 
 This Questionnaire does not constitute an offer to sell or a solicitation of an offer
to buy any security, and the Corporation may never offer to issue any securities to you. Your answers will be kept strictly confidential, and by completing, signing and returning this Questionnaire you are not making any binding commitment to the
Corporation with respect to the Securities of otherwise. However, by signing this Questionnaire, you will be authorizing the Corporation to provide a completed copy of this Questionnaire to such parties as the Corporation deems appropriate in order
to ensure that the offer and sale of the Securities will not result in a violation of the Act or the securities laws of any state and that you otherwise satisfy the suitability standards applicable to purchasers of the Securities. All potential
investors must answer all applicable questions and complete, date and sign this Questionnaire. Please print or type your responses and attach additional sheets of paper if necessary to complete your answers to any item. 

PART A.     BACKGROUND INFORMATION 

Name of Prospective Investor in the Securities:
                                         
                                         
                                         
              
 Social Security or Taxpayer Identification No.
                                         
                                         
                                         
              
 If a corporation, partnership, limited liability company, trust or
other entity: 
 Business Address:
                                         
                                         
                                         
                                         
                   
 (Number and Street) 

 

                          
                                         
                                         
                                         
                                         
                                         
                           

(City)                         
                                         
                          (State)              
                                         
                             (Zip Code) 

Telephone Number: (            )
                                        
                                         
                            

Facsimile Number:
(            )                            
                                         
                                         
   
  

 Name of Contact Person:
                                         
                                         
                                         
                                         
          
 Email Address of Contact Person:
                                         
                                         
                                         
                                   

Type of entity and Nature of Business:
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           

State of formation:
                                         
                                         
                                         
                                         
                 
 Approximate Date of formation:
                                         
                                         
                                         
                                   

Set forth in the space provided below the (i) state(s), if any, in the United States in which you maintained your principal office during the past two
years and the dates during which you maintained your office in each state, and (ii) state(s), if any, in which you pay income taxes: 
  

                          
                                         
                                         
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           

Were you formed for the purpose of investing in the securities being offered? 

Yes
                                        
                                         
           No              
 If
an individual: 
 Residence Address:
                                         
                                         
                                         
                                         
              
 (Number and Street) 

 

                          
                                         
                                         
                                         
                                         
                                         
                           

(City)                         
                                         
                  (State)                      
                                         
                             (Zip Code) 

Telephone Number:
(            )                            
                                 

Facsimile Number:
(            )                            
                                 

Name of Contact Person:
                                         
                                         
                                         
                                         
          
 Email Address of Contact Person:
                                         
                                         
                                         
                                  

Age:
                        Citizenship:
                            Where registered to vote:
                         

Set forth in the space provided below the state(s), if any, in the United States in which you maintained your residence during the past two years and the
dates during which you resided in each state: 
  

                          
                                         
                                         
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           

Current Occupation (if retired, state most recent occupation):
                                         
                                         
                                

Name of Current Employer:
                                         
                                         
                                         
                                         
  
  

 Duration of Current Employment:
                                         
                                         
                                         
                                   

Are you a director or executive officer of the Corporation? 

Yes
                                        
                                         
           No              

Describe any pre-existing personal or business relationship you have with the Company or any of its officers or directors or any other prospective investor in
the Securities: 
  

                          
                                         
                                         
                                         
                                         
                                         
                           
  

                          
                                         
                                         
                                         
                                         
                                         
                           

PART B. ACCREDITED INVESTOR QUESTIONNAIRE 
 In order for the
Company to offer and sell the Securities in conformance with state and federal securities laws, the following information must be obtained regarding your investor status. Please initial each of the below categories that describes you as a potential
investor of the Securities of the Company. 

					
			
	___	  	(1)	  	A bank as defined in Section 3(a)(2) of the Securities Act, or any savings and loan association or other institution as defined in Section 3(a)(5)(A) of the Securities Act whether acting in its individual or fiduciary
capacity;
			
	___	  	(2)	  	A broker or dealer registered pursuant to Section 15 of the Securities Exchange Act of 1934;
			
	___	  	(3)	  	An insurance company as defined in Section 2(a)(13) of the Securities Act;
			
	___	  	(4)	  	An investment company registered under the Investment Company Act of 1940 or a business development company as defined in Section 2(a)(48) of that Act;
			
	___	  	(5)	  	A Small Business Investment Company licensed by the U.S. Small Business Administration under Section 301(c) or (d) of the Small Business Investment Act of 1958;
			
	___	  	(6)	  	A plan established and maintained by a state, its political subdivisions, or any agency or instrumentality of a state or its political subdivisions, for the benefit of its employees, if such plan has total assets in excess of
$5,000,000;
			
	___	  	(7)	  	An employee benefit plan within the meaning of the Employee Retirement Income Security Act of 1974, if the investment decision is made by a plan fiduciary, as defined in Section 3(21) of such act, which is either a bank, savings
and loan association, insurance company, or registered investment adviser, or if the employee benefit plan has total assets in excess of $5,000,000 or, if a self-directed plan, with investment decisions made solely by persons that are accredited
investors;
			
	___	  	(8)	  	A private business development company as defined in Section 202(a)(22) of the Investment Advisers Act of 1940;

					
			
	___	  	(9)	  	An organization described in Section 501(c)(3) of the Internal Revenue Code, a corporation, Massachusetts or similar business trust, or partnership, not formed for the specific purpose of acquiring the Securities, with total
assets in excess of $5,000,000;
			
	___	  	(10)	  	An executive officer or director of the Company;
			
	___	  	(11)	  	A natural person whose individual net worth, or joint net worth with that person’s spouse, at the time of his purchase exceeds $1,000,000 (for purposes of this calculation, net worth is the excess of total assets at fair
market value, including homes (subject to the further description below), automobiles and personal property, over total liability; provided that you should not include your primary residence as an asset, and you should not include as a liability
indebtedness that is secured by your primary residence that is not in excess of the fair market value of your primary residence (except that if the amount of such indebtedness outstanding at the time of sale of the Securities exceeds the amount
outstanding 60 days before such time, other than as a result of the acquisition of the primary residence, the amount of such excess shall be included as a liability));
			
	___	  	(12)	  	A natural person who had an individual income in excess of $200,000 in each of the two most recent years, or joint income with that person’s spouse in excess of $300,000, in each of those years (in each case including
foreign income, tax exempt income and the full amount of capital gains and losses, but excluding any income of other family members and any unrealized capital appreciation), and has a reasonable expectation of reaching the same income level in the
current year;
			
	___	  	(13)	  	A trust, with total assets in excess of $5,000,000, not formed for the specific purpose of acquiring the Securities, whose purchase is directed by a sophisticated person who has such knowledge and experience in financial and
business matters that such person is capable of evaluating the merits and risks of investing in the Company;
			
	___	  	(14)	  	 An entity in which all of the equity owners qualify under any of the above subparagraphs. If the undersigned belongs to this investor
category only, list the equity owners of the undersigned, and the investor category which each such equity owner satisfies:
  

                          
                                         
                                         
                                         
                                         
                                         
 
  

                          
                                         
                                         
                                         
                                         
                                         
 

 (Continue any of the responses in this Questionnaire on a separate piece of paper, if necessary.) 

* * * * * 

							
	 A.     FOR EXECUTION BY AN INDIVIDUAL:

				
	 Date  
	 		 	By:	 	                                     
                                         
                                       
			
		 		 	Print
Name:                                        
                                         
                        
	
	 B.     FOR EXECUTION BY AN ENTITY:

			
		 		 	Entity
Name:                                        
                                         
                      
				
	 Date 
	 		 	By	 	                                     
                                         
                                       
			
		 		 	Print
Name:                                        
                                         
                        
				
		 		 	Title:	 	                                     
                                         
                                       
	
	 C.     ADDITIONAL SIGNATURES (if required by partnership, corporation or trust
document):

			
		 		 	Entity
Name:                                        
                                         
                      
				
	 Date 
	 		 	By	 	                                     
                                         
                                       
			
		 		 	Print
Name:                                        
                                         
                        
				
		 		 	Title:	 	                                     
                                         
                                       
			
		 		 	Entity
Name:                                        
                                         
                      
				
	 Date 
	 		 	By	 	                                     
                                         
                                       
			
		 		 	Print
Name:                                        
                                         
                        
				
		 		 	Title:	 	                                     
                                         
                                       

 EXHIBIT B-2 

STOCK CERTIFICATE QUESTIONNAIRE 

Pursuant to Section 2.2(b) of the Agreement, please provide us with the following information: 

Name of Purchaser (as set forth on the omnibus signature page to the Agreement): 
  

                          
                                         
                                         
                                         
                                         
                                         
                           

Number of Shares Purchased by Purchaser:               
                                         
                                         
                                         
                                     

 

	1.	The exact name in which the Securities are to be registered (this is the name that will appear on the stock certificate(s)) (the “Registered Holder”). You may use a nominee name if appropriate:

  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

	2.	Any relationship between the Purchaser of the Securities and the Registered Holder listed in response to Item 1 above (other than pursuant to the Purchaser’s purchase of the Securities): 

 

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

	3.	The mailing address, telephone and telecopy number of the Registered Holder listed in response to Item 1 above: 

  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     
  

	4.	The Tax Identification Number (or, if an individual, the Social Security Number) of the Registered Holder listed in response to Item 1 above: 

 

                       
                                         
                                         
                                         
                                         
                                         
                     
  

                       
                                         
                                         
                                         
                                         
                                         
                     

 EXHIBIT C 

FORM OF IRREVOCABLE TRANSFER AGENT INSTRUCTIONS 

As of [            ], 2013 

Olde Monmouth Stock Transfer Co., Inc. 
 Transfer Agent and
Registrar 
 200 Memorial Parkway 
 Atlantic Highlands, NJ 07716

 Attn: [            ] 

Ladies and Gentlemen: 
 Reference is made to
that certain Securities Purchase Agreement, dated as of November 1, 2013 (the “Agreement”), by and among Ignyta, Inc., a Nevada corporation (the “Company”), and the purchasers named on the
signature pages thereto (collectively, and including permitted transferees, the “Holders”), pursuant to which the Company is issuing to the Holders shares (the “Shares”) of Common Stock of the Company,
par value $0.00001 per share (the “Common Stock”). 
 This letter shall serve as our irrevocable authorization and
direction to you (provided that you are the transfer agent of the Company at such time and the conditions set forth in this letter are satisfied), subject to any stop transfer instructions that we may issue to you from time to time, if any, to
(i) issue, promptly following the date hereof, certificates representing the Shares bearing the legend set forth herein below, in the names of the Holders and the number of Shares as set forth in the attachments delivered herewith, and to
deliver such certificates within three (3) business days after the date hereof to the address for each such Holder as set forth on such attachments delivered herewith, and (ii) issue certificates representing shares of Common Stock upon
transfer or resale of the Shares, which certificates shall or shall not bear the legend set forth herein below as described below. 
 You
acknowledge and agree that so long as you have received (a) written confirmation from the Company’s legal counsel that a registration statement covering resales of the Shares has been declared effective by the Securities and Exchange
Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), a copy of such registration statement and any other documents reasonably requested by you from the
applicable Holder (and provided that you have not received written instruction from the Company or its legal counsel that such registration statement has been suspended or is no longer effective), (b) written confirmation from the
Company’s legal counsel that the Shares are eligible for sale in conformity with Rule 144 under the Securities Act (“Rule 144”) and customary documentation from a Holder and its broker with respect to a sale pursuant to
Rule 144, or (c) written confirmation from the Company’s legal counsel that the Shares are eligible for sale without the requirement that the Company be in compliance with the current public information requirements of Rule 144 and without
other restriction in conformity with Rule 144, then, unless otherwise required by law, within three (3) business days of your receipt of certificate of Common Stock and documentation required pursuant to clause (a) or (b) above, as
applicable, or a request from a Holder for the issuance of an unlegended certificate in the event that you have received the written confirmation set forth in clause (c) above, you shall issue the certificates representing the Shares registered
in the names of the purchaser of such Shares or the Holder, as the case may be, and such certificates shall not bear any legend restricting transfer of the Shares thereby and should not be subject to any stop-transfer restriction. 

 All certificates representing the Shares issued pursuant to the instruction set forth in clause
(i) of the second paragraph of this letter shall bear the following legend (and, solely to the extent instructed to you by the Company or its legal counsel, a customary “affiliates” legend), and, in the event that you have not
received the documentation required pursuant to clause (a), (b) or (c) of the immediately preceding paragraph, then the certificates representing any shares of Common Stock issued pursuant to the instruction set forth in clause
(ii) of the second paragraph of this letter shall bear the following legend: 
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION
STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OR (B) AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS
EVIDENCED BY A LEGAL OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY. 
 Please be advised that the Holders are relying upon this
letter as an inducement to enter into the Agreement and, accordingly, each Holder is a third party beneficiary to these instructions. 

Please execute this letter in the space indicated to acknowledge your agreement to act in accordance with these instructions. 

 

			
	Very truly yours,
	
	IGNYTA, INC.
		
	By:	 	  

	Name:	 	Jonathan Lim
	Title:	 	President and Chief Executive Officer

 Acknowledged and Agreed: 

OLDE MONMOUTH STOCK TRANSFER CO., INC. 
  

			
	By:	 	  

	Name:	 	
	Title:	 	
	Date:	 	

 EXHIBIT D 

FORM OF SECRETARY’S CERTIFICATE 

Date: [            ], 2013 

The undersigned hereby certifies that he is the duly elected, qualified and acting Secretary of Ignyta, Inc., a Nevada corporation (the
“Company”), and that as such he is authorized to execute and deliver this certificate in the name and on behalf of the Company and in connection with the Securities Purchase Agreement, dated as of November 1, 2013, by
and among the Company and the Purchasers party thereto (the “Securities Purchase Agreement”), and further certifies in his official capacity, in the name and on behalf of the Company, the items set forth below. Capitalized
terms used but not otherwise defined herein shall have the meaning set forth in the Securities Purchase Agreement. 
 1. Attached hereto as
Exhibit A is a true, correct and complete copy of the resolutions duly adopted by the Board of Directors of the Company at a meeting of the Board of Directors held on, or by unanimous written consent dated, October 31, 2013. Such
resolutions have not in any way been amended, modified, revoked or rescinded, have been in full force and effect since their adoption to and including the date hereof and are now in full force and effect. 

2. Attached hereto as Exhibit B is a true, correct and complete copy of the Certificate of Incorporation of the Company, together with
any and all amendments thereto currently in effect, and no action has been taken to further amend, modify or repeal such Certificate of Incorporation, the same being in full force and effect in the attached form as of the date hereof. 

3. Attached hereto as Exhibit C is a true, correct and complete copy of the Bylaws of the Company and any and all amendments thereto
currently in effect, and no action has been taken to further amend, modify or repeal such Bylaws, the same being in full force and effect in the attached form as of the date hereof. 

4. Each person listed below has been duly elected or appointed to the position(s) indicated opposite his name and is duly authorized to sign
the Securities Purchase Agreement and each of the Transaction Documents on behalf of the Company, and the signature appearing opposite such person’s name below is such person’s genuine signature. 

 

					
	 Name
	  	 Position
	  	 Signature

			
	Jonathan Lim	  	President, Chief Executive Officer	  	  

			
	Zachary Hornby	  	Chief Financial Officer, Vice President, Corporate Development, and Secretary	  	  

 IN WITNESS WHEREOF, the
undersigned has executed this Secretary’s Certificate as of the date first written above. 
  

	
	  

	Zachary Hornby
	Secretary

 I, Jonathan Lim, President and Chief Executive Officer of the Company, hereby certify that Zachary
Hornby is the duly elected, qualified and acting Secretary of the Company and that the signature set forth above is his true signature. 
  

	
	  

	 Jonathan Lim

	 President, Chief Executive Officer

 EXHIBIT A 

RESOLUTIONS 

 EXHIBIT B 

CERTIFICATE OF INCORPORATION 

 EXHIBIT C 

BYLAWS 

 EXHIBIT E 

FORM OF COMPLIANCE CERTIFICATE 

Date: [            ], 2013 

The undersigned President and Chief Executive Officer of Ignyta, Inc., a Nevada corporation (the “Company”), pursuant
to Section 2.2(a)(vi) of the Securities Purchase Agreement, dated as of November 1, 2013, by and among the Company and the Purchasers signatory thereto (the “Agreement”), hereby certifies to such Purchasers as
follows (capitalized terms used but not otherwise defined herein shall have the meaning set forth in the Agreement): 
 1. The
representations and warranties of the Company contained in the Agreement are true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and
warranties are true and correct in all respects) as of the date when made and as of the Closing Date, as though made on and as of such date, except for such representations and warranties that speak as of a different specified date. 

2. The Company has performed, satisfied and complied in all material respects with all covenants, agreements and conditions required by the
Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing. 

 IN WITNESS WHEREOF, the undersigned has
executed this Compliance Certificate as of the date first written above. 
  

	
	  

	Jonathan Lim
	President and Chief Executive Officer

 EXHIBIT F 

FORM OF LOCK-UP AGREEMENT 

LOCK-UP AGREEMENT 

[            ], 2013 

Ladenburg Thalmann & Co. 
 570 Lexington Avenue, 12th Floor 
 New York, New York 10022 

Ladies & Gentlemen: 
 The undersigned
is an owner of record or beneficially of certain shares of common stock, par value $0.00001 per share, of Ignyta, Inc., a Nevada corporation (the “Company” and the “Shares”), or securities convertible into or
exchangeable or exercisable for Shares. The Company proposes to carry out a private offering of Shares (the “Offering”) for which Ladenburg Thalmann & Co. Inc. will act as placement agent (the “Placement
Agent”). The undersigned recognizes that the Offering will be of benefit to the undersigned and will benefit the Company by, among other things, raising additional capital for its operations. The undersigned acknowledges that the Company
and the Placement Agent are relying on the representations and agreements of the undersigned contained in this letter agreement in carrying out the Offering. 

In consideration of the foregoing, the undersigned hereby agrees that the undersigned will not, without the prior written consent of the
Placement Agent (which consent may be withheld in its sole discretion), (i) directly or indirectly, sell, offer, contract or grant any option to sell (including without limitation any short sale), pledge, transfer, establish an open “put
equivalent position” within the meaning of Rule 16a-1(h) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise dispose of any Shares, options or warrants to acquire Shares, or securities
exchangeable or exercisable for or convertible into Shares currently or hereafter owned either of record or beneficially (as defined in Rule 13d-3 under the Exchange Act) by the undersigned (or such spouse or family member), (ii) enter
into any swap, hedge or other agreement or arrangement that transfers, in whole or in part, the economic risk of ownership of any Shares or securities exchangeable or exercisable for or convertible into Shares, (iii) engage in any short selling
of any Shares or securities exchangeable or exercisable for or convertible into Shares, or (iv) publicly announce an intention to do any of the foregoing, for a period commencing on the date hereof and continuing through the close of trading on
the date 180 days after the date of the closing of the Offering (the “Lock-up Period”); provided, that the foregoing restrictions shall not apply (a) to the transfer of any or all of the Shares owned by the
undersigned (1) by bona fide gift; (2) either during the undersigned’s lifetime or on death, by will or intestate succession to the immediate family of the undersigned or to a trust the beneficiaries of which are, or a partnership of
limited liability company for the benefit of, exclusively the undersigned and/or a member or members of the undersigned’s immediate family; or (3) to affiliates of the undersigned, including its partners or members, if applicable, or to
any investment fund or other entity controlled or managed by the undersigned; provided, that in any such case, it shall be a condition to such transfer that the transferee executes and delivers to the Company an agreement stating that the
transferee is receiving and holding the Shares subject to the provisions of this letter agreement, and there shall be no further transfer of such Shares, except in accordance with this letter agreement; (b) to the exercise of stock options or
warrants or the conversion of convertible securities, provided, that the Shares received upon such exercise or conversion shall be subject to the terms of this agreement; or (c) to the establishment of any 10b5-1 trading plan with
respect to the Shares, provided that no transfers are permitted to be made under any such plan during the 

 
Lock-Up Period. For the purposes of this paragraph, “immediate family” shall mean the spouse, domestic partner, lineal descendant (including adopted and step children and
grandchildren), father, mother, brother, sister, stepparent, grandparent, or mother-, father-, son-, daughter-, brother- or sister-in-law of the transferor. 

The foregoing restrictions shall not apply to the transfer of any or all the Shares owned by the undersigned in connection with any merger or
plan of reorganization that is approved by the Board of Directors of the Company. The undersigned expressly agrees that the foregoing restrictions shall in the event of any merger or plan of reorganization that is approved by the Board of Directors
of the Company subsequently apply to any securities received by the undersigned in any such merger or plan of reorganization in exchange for Shares or other securities convertible into or exchangeable or exercisable for Shares. 

The undersigned also agrees and consents to the entry of stop transfer instructions with the Company’s transfer agent and registrar
against the transfer of Shares or securities convertible into or exchangeable or exercisable for Shares held by the undersigned except in compliance with the foregoing restrictions. 

This agreement is irrevocable and will be binding on the undersigned and the respective successors, heirs, personal representatives, and
assigns of the undersigned. However, it is understood that, if (i) the Company notifies the Placement Agent in writing that it does not intend to proceed with the Offering, or (ii) if the purchase agreements relating to the Offering (other
than the provisions thereof which survive termination) shall terminate or be terminated for any reason prior to payment for and delivery of the Shares to be sold thereunder, this letter agreement shall immediately be terminated and the undersigned
shall automatically be released from all of the obligations under this letter agreement. 
  

	
	 Very truly yours,

	
	  

	(Name of Stockholder – Please Print)
	
	  

	(Signature)
	
	  

	(Name of Signatory if Stockholder is an entity—Please Print)
	
	  

	(Title of Signatory if Stockholder is an entity—Please Print)

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