Document:

EX-10.22

 Exhibit 10.22 

Amphastar 2-1-17 

 
  

 
 ASSET PURCHASE AGREEMENT 

between 
 ATHENEX, INC. 

and 
 AMPHASTAR PHARMACEUTICALS,
INC. 
 Dated as of February 1, 2017 
  

 
  

 TABLE OF CONTENTS 
  

											
	 	    	 	  	 	  	 	  	Page	 
			
	 ARTICLE I
	  	 PURCHASE AND SALE
	  	 	4	 
					
		    	Section 1.01.	  		  	 Purchase and Sale
	  	 	4	 
		    	Section 1.02.	  		  	 Transferred Assets and Excluded Assets.
	  	 	5	 
		    	Section 1.03.	  		  	 Assumption of Liabilities; Retained Liabilities
	  	 	6	 
			
	 ARTICLE II
	  	 CLOSING
	  	 	7	 
					
		    	Section 2.01.	  		  	 Closing
	  	 	7	 
		    	Section 2.02.	  		  	 Transactions To Be Effected at the Closing
	  	 	7	 
			
	 ARTICLE III
	  	 REPRESENTATIONS AND WARRANTIES OF SELLER
	  	 	8	 
					
		    	Section 3.01.	  		  	 Organization and Standing
	  	 	8	 
		    	Section 3.02.	  		  	 Authority; Execution and Delivery; Enforceability
	  	 	8	 
		    	Section 3.03.	  		  	 Non-Contravention and Approvals
	  	 	8	 
		    	Section 3.04.	  		  	 Title to Assets
	  	 	9	 
		    	Section 3.05.	  		  	 Litigation
	  	 	9	 
		    	Section 3.06.	  		  	 Regulatory Approvals; Compliance Arrangements
	  	 	9	 
		    	Section 3.07.	  		  	 Hikma Asset Purchase Agreement
	  	 	9	 
		    	Section 3.08.	  		  	 API
	  	 	10	 
		    	Section 3.09.	  		  	 Representations Complete
	  	 	10	 
			
	 ARTICLE IV
	  	 REPRESENTATIONS AND WARRANTIES OF PURCHASER
	  	 	10	 
					
		    	Section 4.01.	  		  	 Organization
	  	 	10	 
		    	Section 4.02.	  		  	 Authority; Execution and Delivery; Enforceability
	  	 	10	 
		    	Section 4.03.	  		  	 Non-Contravention and Approvals
	  	 	11	 
		    	Section 4.04.	  		  	 Litigation
	  	 	11	 
		    	Section 4.05.	  		  	 No Brokers’ Fees
	  	 	11	 
		    	Section 4.06.	  		  	 Seller’s Representations; Independent Investigation
	  	 	11	 
			
	 ARTICLE V
	  	 COVENANTS
	  	 	13	 
					
		    	Section 5.01.	  		  	 Access to Information
	  	 	13	 
		    	Section 5.02.	  		  	 Confidentiality
	  	 	14	 
		    	Section 5.03.	  		  	 Publicity
	  	 	15	 
		    	Section 5.04.	  		  	 Covenant Not to Sue
	  	 	15	 
		    	Section 5.07.	  		  	 Insurance
	  	 	15	 
		    	Section 5.06.	  		  	 Change in Ownership Letters
	  	 	16	 
		    	Section 5.07.	  		  	 Tax Covenants
	  	 	16	 

											
	 ARTICLE VI
	  	 CLOSING DELIVERABLES
	  	 	17	 
					
		    	Section 6.01.	  		  	 Seller Deliverables
	  	 	17	 
		    	Section 6.02.	  		  	 Purchaser Deliverables
	  	 	17	 
			
	 ARTICLE VIII
	  	 INDEMNIFICATION; SURVIVAL
	  	 	17	 
					
		    	Section 7.01.	  		  	 Indemnification by Seller
	  	 	17	 
		    	Section 7.02.	  		  	 Indemnification by Purchaser
	  	 	17	 
		    	Section 7.03.	  		  	 Indemnification Procedures
	  	 	18	 
		    	Section 7.04.	  		  	 Limitations on Indemnification
	  	 	19	 
		    	Section 7.05.	  		  	 Calculation of Indemnity Payments
	  	 	19	 
		    	Section 7.06.	  		  	 Exclusive Remedy
	  	 	20	 
		    	Section 7.07.	  		  	 Tax Treatment of Indemnification
	  	 	21	 
		    	Section 7.08.	  		  	 Survival
	  	 	21	 
		    	Section 7.09.	  		  	 No Setoff Rights
	  	 	21	 
			
	 ARTICLE IX
	  	 MISCELLANEOUS
	  	 	22	 
					
		    	Section 8.01.	  		  	 Assignment
	  	 	22	 
		    	Section 8.02.	  		  	 No Third-Party Beneficiaries
	  	 	22	 
		    	Section 8.03.	  		  	 Expenses
	  	 	22	 
		    	Section 8.04.	  		  	 Notices
	  	 	22	 
		    	Section 8.05.	  		  	 Interpretation; Certain Definitions
	  	 	23	 
		    	Section 8.06.	  		  	 Limitation on Damages
	  	 	27	 
		    	Section 8.07.	  		  	 Counterparts
	  	 	27	 
		    	Section 8.08.	  		  	 Entire Agreement
	  	 	27	 
		    	Section 8.09.	  		  	 Severability
	  	 	28	 
		    	Section 8.10.	  		  	 Governing Law
	  	 	28	 
		    	Section 8.11.	  		  	 Jurisdiction
	  	 	28	 
		    	Section 8.12.	  		  	 Service of Process
	  	 	28	 
		    	Section 8.13.	  		  	 Waiver of Jury Trial
	  	 	29	 
		    	Section 8.14.	  		  	 Amendments and Waivers
	  	 	29	 
		    	Section 8.15.	  		  	 Specific Performance
	  	 	29	 
		    	Section 8.16.	  		  	 Joint Drafting
	  	 	29	 
		    	Section 8.17.	  		  	Fulfillment of Obligations	  	 	29	 

  

					
	 Exhibit A
	  		  	 Forms of Transfer Documents

	 Exhibit B
	  		  	 Form of Purchaser Change in Ownership Letters

	 Exhibit C
	  		  	 Form of Seller Change in Ownership Letters

 ASSET PURCHASE AGREEMENT dated as of
                    , 2017 (this “Agreement”), between Athenex, Inc., a Delaware corporation (“Purchaser”) and
Amphastar Pharmaceuticals, Inc., a Delaware corporation (“Seller”). 
 WHEREAS, pursuant to an asset purchase agreement
dated as of March 4, 2016 (the “Hikma Asset Purchase Agreement”), Seller purchased certain assets, including the Transferred Assets (as defined herein), from Hikma Pharmaceuticals PLC, a public limited company incorporated in
England and Wales (“Hikma”) (the “Hikma Acquisition”); 
 WHEREAS, Seller owns the Transferred
Assets; 
 WHEREAS, Seller desires to sell, transfer and deliver the Transferred Assets to Purchaser and Purchaser desires to acquire such
Transferred Assets, upon the terms and subject to the conditions of this Agreement. 
 NOW, THEREFORE, in consideration of the premises and
the mutual agreements and covenants hereinafter set forth, and intending to be legally bound, the parties hereby agree as follows: 
 ARTICLE
I 
 PURCHASE AND SALE 

SECTION 1.01. Purchase and Sale. 

(a) Purchase Price. Upon the terms and subject to the conditions of this Agreement, at the Closing, Seller will sell, transfer, assign,
convey and deliver to Purchaser, and Purchaser will purchase, acquire and accept from Seller, all of Seller’s right, title and interest in, to and under the Transferred Assets as of the Closing, free and clear of all Liens (other than Permitted
Liens) for (a) an aggregate purchase price of $6.4 million in cash to be paid in accordance with the terms and conditions of Section 2.02(b) (the “Purchase Price”); and (b) the assumption by Purchaser of the Assumed
Liabilities. The purchase and sale of the Transferred Assets and the assumption of the Assumed Liabilities are collectively referred to in this Agreement as the “Acquisition”. 

(b) Royalty. In addition to the Purchase Price, Purchaser agrees to pay Seller a royalty fee equal to 2% of Net Sales (if any) which
are derived from Purchaser’s sales of the Products from the Transferred Assets (the “Royalty Fee”) for a period beginning as of the date of Closing and continuing until the tenth
(10th) anniversary of the Closing Date (the “Royalty Term”). Such Royalty Fee shall be cumulated, will be in U.S. Dollars and paid to Seller within forty-five (45) days of
the end of each calendar quarter during the Royalty Term; it being understood that the Royalty Fee payments shall be reconciled, to the extent necessary, in any subsequent quarter during the Royalty Term or at the end of the Royalty Term, as the
case may be, based on the actual Net Sales realized by Purchaser. Purchaser shall provide Seller with a written statement setting forth the number of Product units sold and the Royalty Fee due during

 
each calendar quarter during the Royalty Term within thirty (30) days of the end of each calendar quarter. The Purchaser shall maintain and keep for a period of not less than two
(2) years complete and accurate records in sufficient detail to enable any accrued royalties to be calculated. During normal business hours and with reasonable advance written notice but in no event less than twenty (20) Business Days and
not exceeding once a year during the Royalty Term, Purchaser shall permit a Representative of Seller to have access to such records of Purchaser as may be necessary to verify the accuracy of the records related to the Royalty Fees paid to Seller (in
each case, a “Seller Audit”); provided however that any such Seller Audit must take place no more than one (1) year following the end of the calendar year during the Royalty Term at issue and will be at Seller’s expense
unless the mutually agreed upon accounting firm audit finds that the royalties have been under reported by more than 5%, in which case Buyer will pay for the audit. Promptly following Seller’s completion of any such Seller Audit (but in no
event later than thirty (30) days following such completion), Seller shall deliver to Purchaser written notice of the results of such Seller Audit, including a description in reasonable detail of any proposed adjustments to the Royalty Fees
actually paid to Seller for the applicable period covered by such Seller Audit. Seller and Purchaser will negotiate in good faith to resolve any dispute over Seller’s proposed adjustments to the Royalty Fees, provided that if any such dispute
is not resolved within thirty (30) days following receipt by Purchaser of the proposed adjustments, either Purchaser or Seller may engage a mutually agreed upon accounting firm with a national presence (the “Accounting Firm”)
on behalf of Purchaser and Seller to resolve any remaining dispute of Seller’s proposed adjustments, which resolution will be final. The Accounting Firm will be instructed to deliver its written determination within thirty (30) days. The
Accounting Firm will address only those items in dispute and may not assign a value greater than the greatest value for such item claimed by either party or a value smaller than the smallest value for such item claimed by either party. The fees and
expenses of the Accounting Firm will be shared by the parties in inverse proportion to the percentage of the disputed amount determined by the Accounting Firm to be in favor of Seller, on the hand, and Purchaser, on the other hand. The calculation
and amount of the Royalty Fees for the period covered by any Seller Audit will become final and binding on all parties upon the earliest of (i) Seller’s delivery of notice to Purchaser of the results of the Seller Audit whereby such
results reflect Seller’s agreement with the amount of Royalty Fees actually paid to Seller, (ii) the mutual agreement of Seller and Purchaser with respect to any of Seller’s proposed adjustments to the Royalty Fees actually paid to
Seller, and (iii) the Accounting Firm’s final resolution of any disputes submitted to the Accounting Firm. Promptly after such final determination of the amount of the Royalty Fees for the period covered by any Seller Audit: (x) if
such finally determined Royalty Fee amount exceeds the amount actually paid to Seller, then Purchaser will pay to Seller an amount equal to such excess within thirty (30) days after such final determination; or (ii) if the amount of
Royalty Fees actually paid to Seller exceed such finally determined Royalty Fee amount, then Seller will refund to Purchaser an amount equal to such excess within thirty (30) days after such final determination. 

 SECTION 1.02. Transferred Assets and Excluded Assets. 

(a) The term “Transferred Assets” means all of Seller’s right, title and interest in, to and under the following assets
as they exist at the time of the Closing: 
 (i) all books, records, files, data and other documentation in the categories, to the extent
applicable and obtained from Hikma, set forth in Section 1.02(a)(i) of the Seller Disclosure Schedule that are exclusively related to the Products or the Transferred Assets (except to the extent in the possession or control of a Governmental Entity
or a contract manufacturer of the Products) and as provided in Section 5.01 (collectively, the “Transferred Books and Records”); 

(ii) all ANDAs listed in Section 1.02(a)(ii) of the Seller Disclosure Schedule (the “Regulatory Approvals”); and 

(iii) all of the inventory for the Active Pharmaceuticals Ingredients (“API”) as of the Closing listed in Section
1.02(a)(iii) of the Seller Disclosure Schedule. 
 (b) Notwithstanding anything to the contrary contained in this Agreement, (A) no
Excluded Asset (as defined below) shall be included within the Transferred Assets and (B) Seller shall not sell, transfer, assign or deliver to Purchaser, and Purchaser shall not purchase, acquire or accept, any right, title and interest of
Seller in, to or under the Commingled Documents or any assets of Seller or its affiliates not expressly included in the Transferred Assets (all such other assets, the “Excluded Assets”); provided, that Seller shall use
commercially reasonable efforts to provide Purchaser with access to the Commingled Documents in accordance with Section 5.01. 
 (c)
Subject to Section 5.02(b) and in accordance with Section 5.01, Seller shall have the right to retain copies of and have access to the documents, materials and data relating to the ownership, use, sale, license or lease of the Transferred
Assets prior to the Closing Date. 
 SECTION 1.03. Assumption of Liabilities; Retained Liabilities. 

(a) Upon the terms and subject to the conditions of this Agreement Purchaser shall assume, effective as of the Closing, and shall pay, perform
and discharge when due, any and all obligations, liabilities and commitments of any nature, whether known or unknown, express or implied, primary or secondary, direct or indirect, liquidated, absolute, accrued, contingent or otherwise and whether
due or to become due (collectively, “Liabilities”): 
 (i) related to or arising out of the ownership, use, sale, license
or lease of the Transferred Assets by Purchaser from and after the Closing Date, including all Liabilities (A) related to or arising out of products liability Claims with respect to the Exploitation of any Product on or after the Closing Date
or (B) related to or arising out of government seizures, filed corrections, withdrawals or recalls of Product sold on or after the Closing Date; 

(ii) concerning the use of any third party Intellectual Property (“IP Liabilities”), arising out of or related to any
Exploitation of Product on or after the Closing Date; 

 (iii) for Transfer Taxes and Apportioned Obligations allocated to Purchaser under
Section 5.07; and 
 (iv) related to or arising out of the matters set forth in Section 1.03(a)(iv) of the Seller Disclosure Schedules.

 The Liabilities referenced in clauses (i) through (iv) above are referred to, collectively, as the “Assumed
Liabilities”. 
 (b) The term “Retained Liabilities” means all Liabilities of Seller and its affiliates, including
without limitation to the extent related to the Transferred Assets, other than the Assumed Liabilities. 
 ARTICLE II 

CLOSING 
 SECTION 2.01.
Closing. The closing of the Acquisition (the “Closing”) shall take place by the electronic exchange of documents and signature pages on the date hereof (the “Closing Date).” 

SECTION 2.02. Transactions To Be Effected at the Closing. 

(a) At the Closing, Seller shall deliver or cause to be delivered to Purchaser duly executed binding term sheet, bills of sale, assignments,
licenses and other instruments of transfer relating to the Transferred Assets, in each case in the form attached hereto as Exhibit A. 
 (b)
At the Closing, Purchaser shall deliver or cause to be delivered to Seller within fifteen (15) business days of the Closing Date (i) payment, by wire transfer of immediately available funds to one or more accounts designated in writing by
Seller (such designation to be made at least fifteen (15) days prior to the Closing Date), of $1.0 million and (ii) duly executed counterparts to the bills of sale, assignments, licenses and other instruments of transfer referred to
in Section 2.02(a), and duly executed assumption agreements and other instruments of assumption providing for the assumption of the Assumed Liabilities, in each case reasonably acceptable to Purchaser and Seller. A second payment in the amount of
$1.0 million will be made by Purchaser to Seller within 30 days of May 1, 2017. A third payment in the amount of $3.0 million will be paid within 30 days of receiving FDA approval of site transfer to sell Prochlorperazine Edisylate
Injection USP and a fourth payment in the amount of $1.4 million will be paid by Purchaser to Seller within 30 days of FDA approval of site transfer of the second product to be FDA approved. If the third and fourth payment milestones are not
reached by December 31, 2017, Purchaser will pay the balance of the $4.4 million within 30 days of December 31, 2017. All of the risk of loss with respect to the Transferred Assets (whether or not covered by insurance) shall be on
Seller up to the time of the Closing, whereupon such risk of loss with respect to the Transferred Assets shall pass to Purchaser. Notwithstanding anything to the contrary contained in this Agreement except as a result of a breach by Seller or its
affiliates 

 
of this Agreement, and/or during the pendency of any disputes arising under or related hereto (whether for breach of contract, tortious conduct or otherwise), in the event that Purchaser fails to
make any of the required payments set forth in this Section 2.02(b) (“Payment Breach”), and fails to cure such Payment Breach within 45 days written of notice in accordance with Section 8.04 thereof, Purchaser agrees to transfer the
ownership of the Transferred Assets to Seller and Purchaser shall have no right of recourse to any of the previous payments. 
 (c) 

ARTICLE III 
 REPRESENTATIONS AND
WARRANTIES OF SELLER 
 Except as set forth in the disclosure schedules of Seller (the “Seller Disclosure Schedule”),
Seller hereby represents and warrants to Purchaser as follows: 
 SECTION 3.01. Organization and Standing. Seller is a legal
entity duly organized, validly existing and in good standing under the Laws of the jurisdiction of its organization. Seller has the requisite power and authority to enable it to own, lease, license or otherwise hold the Transferred Assets owned,
leased, licensed or otherwise held by it. 
 SECTION 3.02. Authority; Execution and Delivery; Enforceability. Seller has the
requisite power and authority to execute and deliver this Agreement and the other agreements and instruments to be executed and delivered by it in connection with this Agreement (the “Ancillary Agreements”) to which it will be a
party and to consummate the Acquisition and the other transactions contemplated to be consummated by it by this Agreement and such Ancillary Agreements. Seller has taken all action required by its organizational documents to authorize the execution
and delivery of this Agreement and the Ancillary Agreements and to authorize the consummation of the Acquisition and the other transactions contemplated to be consummated by it by this Agreement and such Ancillary Agreements. Seller has duly
executed and delivered this Agreement and each Ancillary Agreement, and (assuming the due authorization, execution and delivery by the other parties hereto) this Agreement and each Ancillary Agreement constitutes its legal, valid and binding
obligation, enforceable against it in accordance with its terms subject, as to enforcement, to applicable bankruptcy, insolvency, moratorium, reorganization, fraudulent conveyance or similar Laws affecting the enforcement of creditors’ rights
generally and to general equitable principles (whether considered in a Proceeding in equity or at law) (the “Enforceability Exceptions”). 

SECTION 3.03. Non-Contravention and Approvals. 

(a) The execution and delivery by Seller of this Agreement and each Ancillary Agreement does not, and the consummation by Seller of the
Acquisition and the other transactions contemplated to be consummated by it by this Agreement and such Ancillary Agreements will not, (i) conflict with or violate the organizational documents of Seller, (ii) assuming compliance with
Section 3.03(b), conflict with or violate any judgment, injunction, 

 
order or decree (“Judgment”) or federal, national, supranational, state, provincial, local, foreign or administrative statute, law, ordinance, rule, code or regulation
(“Law”) to which Seller or any of the Transferred Assets is subject or (iii) result in the creation of any Lien (other than Permitted Liens or Liens arising from any act of Purchaser or its affiliates) upon any of the
Transferred Assets, except, in the case of clauses (ii) and (iii), for any such items that would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the Transferred Assets or materially impede or
materially delay the consummation by Seller of the Acquisition and the other transactions contemplated by this Agreement (“a Material Adverse Effect”). 

(b) Except as contemplated by this Agreement, no consent, approval, waiver, notice or authorization (“Consent”) of, or
registration, declaration or filing with, any Governmental Entity is required to be obtained, given or made by Seller in connection with the execution, delivery and performance of this Agreement or the Ancillary Agreements, or the consummation of
the Acquisition other than (i) those that may be required solely by reason of Purchaser’s (as opposed to any other third party’s) participation in the Acquisition and the other transactions contemplated by this Agreement and by the
Ancillary Agreements and (ii) those the failure of which to obtain, give or make would not, individually or in the aggregate, constitute a Material Adverse Effect. 

SECTION 3.04. Title to Assets. Seller has good and marketable title to, and is transferring to Purchaser all of Seller’s
right, title and interests in and to, the Transferred Assets, in each case free and clear of any mortgages, liens, pledges, security interests, charges or other encumbrances of any kind (collectively, “Liens”), except for Permitted
Liens. 
 SECTION 3.05. Litigation. There are no Proceedings pending or, to the knowledge of Seller, threatened in writing
against Seller or any of its affiliates which relate to the Transferred Assets and which, in all cases would, individually or in the aggregate, constitute a Material Adverse Effect. None of Seller or any of its affiliates is party or subject to or
in default under any unsatisfied Judgment applicable to the Transferred Assets, other than such Judgments that would not, individually or in the aggregate, constitute a Material Adverse Effect. 

SECTION 3.06. Regulatory Approvals; Compliance Arrangements. To the knowledge of Seller, each Regulatory Approval is valid,
effective and in full force and effect in all material respects, and all applicable fees and costs that are due and payable with respect to such Regulatory Approvals have been paid in full. 

SECTION 3.07. Hikma Asset Purchase Agreement. With respect to the agreements and covenants of Seller concerning the sale,
transfer, assignment, conveyance, and delivery of, and access to, the Transferred Assets and the Commingled Documents (including Seller Commingled Information and Purchaser Commingled Information) that are set forth in Sections 1.01, 1.02, and
5.01(I) of this Agreement (and as such terms are defined in this Agreement), the Hikma Asset Purchase Agreement contains the same or substantially the same agreements and covenants with respect to the Transferred Assets and Commingled Documents (as
between Hikma and Seller), other than with respect to (i) purchase price, (ii) efforts standards 

 
with respect to the delivery of and access to the Transferred Assets and Commingled Documents and (iii) the last sentence of Section 5.01(I) of this Agreement. The seller will provide a
copy of the Hikma Asset Purchase Agreement to the Purchaser. 
 SECTION 3.08. API. All inventory of API set forth on Section
1.02(a)(iii) of the Seller Disclosure Schedule that is unexpired (as indicated in the column titled “Expiry”) as of the Closing Date is usable and of a quality in accordance with applicable FDA guidelines through the date of expiry. 

SECTION 3.09. Representations Complete. Other than the representations and warranties of Seller specifically contained in this
Article III, there are no representations or warranties of Seller or any other person either expressed or implied with respect to the Transferred Assets, the Assumed Liabilities, or the transactions contemplated hereby, individually or collectively.
None of Seller, its affiliates or its Representatives makes any representations or warranties relating to (i) the maintenance, repair, condition, design, performance or marketability of any Transferred Asset, including merchantability of
fitness for a particular purpose, (ii) the Exploitation of the Products by Seller on or prior to the Closing, (iii) the ownership, use, sale, license or lease of the Transferred Assets by Purchaser after the Closing or (iv) the
Exploitation of the Transferred Assets by Purchaser after the Closing, including the probable success or profitability of the Exploitation of the Products after the Closing. Nothing in this Section 3.09 or otherwise in this Agreement shall
limit any claim for fraud or intentional misrepresentation. 
 ARTICLE IV 

REPRESENTATIONS AND WARRANTIES OF PURCHASER 

Purchaser hereby represents and warrants to Seller as follows: 

SECTION 4.01. Organization. Purchaser is a legal entity duly organized, validly existing and in good standing under the Laws of
the jurisdiction of its organization or incorporation. 
 SECTION 4.02. Purchaser agrees to make timely payments to seller in
accordance with section 2.02(b) 
 SECTION 4.03. Authority; Execution and Delivery; Enforceability. Purchaser has the
requisite power and authority to execute and deliver this Agreement and the Ancillary Agreements to which it will be a party and to consummate the Acquisition and the other transactions contemplated to be consummated by it by this Agreement and such
Ancillary Agreements. Purchaser has taken all action required by its organizational documents to authorize the execution and delivery of this Agreement and the Ancillary Agreements and to authorize the consummation of the Acquisition and the other
transactions contemplated to be consummated by it by this Agreement and such Ancillary Agreements. Purchaser has duly executed and delivered this Agreement and each Ancillary Agreement, and (assuming the due

 
authorization, execution and delivery by the other parties hereto) this Agreement and each Ancillary Agreement constitutes its legal, valid and binding obligation, enforceable against it in
accordance with its terms subject, as to enforcement, to the Enforceability Exceptions. 
 SECTION 4.04. Non-Contravention and Approvals. 
 (a) The execution and delivery by Purchaser of this Agreement and
each Ancillary Agreement, the consummation by Purchaser of the Acquisition and the other transactions contemplated to be consummated by it hereunder and the consummation by Purchaser of the transactions contemplated to be consummated by them under
the Ancillary Agreements will not, (i) conflict with or violate the organizational documents of Purchaser, (ii) result in any violation of, breach of or constitute a default under, or give rise to a right of termination, cancellation,
payment or acceleration of any obligation or loss of a benefit under, any Contract to which Purchaser is a party or by which any of its properties or assets is bound, (iii) assuming compliance with Section 4.04(b), conflict with or violate
any Judgment or Law to which Purchaser or its properties or assets are subject or (iv) result in the creation of any Lien upon any of the properties or assets of Purchaser, except, in the case of clauses (ii) through (iv), for any such
items that would not, individually or in the aggregate, reasonably be expected to result in any event, change, occurrence or effect that prevents or materially impedes or materially delays the consummation by Purchaser of the Acquisition and the
other transactions contemplated by this Agreement (a “Purchaser Material Adverse Effect”). 
 (b) No Consent of, or
registration, declaration or filing with, any Governmental Entity is required to be obtained, given or made by Purchaser in connection with the execution, delivery and performance of this Agreement or the Ancillary Agreements or the consummation of
the Acquisition, other than (i) those that may be required solely by reason of Seller’s (as opposed to any other third party’s) participation in the Acquisition and the other transactions contemplated by this Agreement and by the
Ancillary Agreements, and (ii) those the failure of which to obtain, give or make would not, individually or in the aggregate, constitute a Purchaser Material Adverse Effect. 

SECTION 4.05. Litigation. There are no Proceedings or Claims pending or, to the knowledge of Purchaser, threatened in writing
against Purchaser or any of its affiliates that, in any such case, would, individually or in the aggregate, constitute a Purchaser Material Adverse Effect. Neither Purchaser nor any of its affiliates is party or subject to or in default under any
unsatisfied Judgment, other than such Judgments that would not, individually or in the aggregate, constitute a Purchaser Material Adverse Effect. 

SECTION 4.06. No Brokers’ Fees. Purchaser has not taken any action that would entitle any person to any commission or
broker’s fee in connection with the transactions contemplated by this Agreement. 

 SECTION 4.07. Seller’s Representations; Independent Investigation. 

(a) Purchaser acknowledges and agrees that, other than the representations and warranties of Seller specifically contained in Article III,
there are no representations or warranties of Seller or any other person either expressed or implied with respect to the Transferred Assets, the Assumed Liabilities, or the transactions contemplated hereby, individually or collectively. Purchaser,
together with and on behalf of its affiliates and Representatives, specifically disclaims that it or they are relying upon or have relied upon any such other representations or warranties that may have been made by any person, and Purchaser,
together with and on behalf of its affiliates and Representatives, acknowledges and agrees that Seller and its affiliates have specifically disclaimed and do hereby specifically disclaim any such other representation or warranty made by any person.
Without limiting the generality of the foregoing, Purchaser acknowledges and agrees that none of Seller, its affiliates or its Representatives makes any representations or warranties relating to (i) the maintenance, repair, condition, design,
performance or marketability of any Transferred Asset, including merchantability of fitness for a particular purpose, (ii) the Exploitation of the Products by Seller on or prior to the Closing, (iii) the ownership, use, sale, license or
lease of the Transferred Assets by Purchaser after the Closing or (iv) the Exploitation of the Transferred Assets by Purchaser after the Closing, including the probable success or profitability of the Exploitation of the Products after the
Closing. Except as set forth in the representations and warranties in Article III, Purchaser acknowledges and agrees that it shall obtain rights in the Transferred Assets in their present condition and state of repair, “as is” and
“where is.” Nothing in this Section 4.06 or otherwise in this Agreement shall limit any claim for fraud or intentional misrepresentation. 

(b) Purchaser acknowledges that Purchaser, its affiliates and their respective Representatives have been permitted full access to the books
and records, facilities, equipment, personnel and other properties and assets relating to the Transferred Assets that Purchaser, its affiliates and their respective Representatives have desired or requested to see and review, and that Purchaser, its
affiliates and their respective Representatives have had a full opportunity to conduct and complete a due diligence investigation of the Transferred Assets and the Assumed Liabilities. Except as expressly set forth in any representation or warranty
in Article III, Purchaser acknowledges and agrees that no person, including the Purchaser Indemnitees, shall have any claim (whether in warranty, contract, tort (including negligence or strict liability) or otherwise) or right to indemnification
pursuant to Article VII (or otherwise) with respect to any information, documents or materials made available or otherwise furnished to or for Purchaser, its affiliates or their respective Representatives by Seller, Hikma, any of their respective
affiliates, or any of their respective Representatives, including any financial projections or other statements regarding future performance and any other information, documents or material, whether oral or written, made available to Purchaser, its
affiliates or their respective Representatives in any “data room,” management presentation, “break-out” discussions or meetings, responses to questions submitted on behalf of Purchaser, its
affiliates or their respective Representatives or otherwise furnished to Purchaser, its affiliates or their respective Representatives in any form in expectation of the transactions contemplated hereby, except, for avoidance of doubt, insofar as
such claim or indemnification relates to a Retained Liability or an Excluded Asset. 

 (c) Purchaser, its affiliates and their respective Representatives may have received and may
continue to receive from Seller, Hikma, their respective affiliates and their respective Representatives certain estimates, projections and other forecasts and certain plan and budget information. Purchaser acknowledges that these estimates,
projections, forecasts, plans and budgets, and the assumptions on which they are based, were prepared for specific purposes and may vary significantly from each other. Further, Purchaser acknowledges that there are uncertainties inherent in
attempting to make such estimates, projections, forecasts, plans and budgets, that Purchaser is taking full responsibility for making its own evaluation of the adequacy and accuracy of all estimates, projections, forecasts, plans and budgets so
furnished to it, its affiliates or their respective Representatives (including the reasonableness of the assumptions underlying such estimates, projections, forecasts, plans and budgets) and that Purchaser is not relying on, and Seller and its
affiliates have not made and are not making any representations or warranties with respect to, any estimates, projections, forecasts, plans or budgets made available or otherwise furnished by Seller, Hikma, their respective affiliates or their
respective Representatives, and Purchaser shall not, and shall cause its affiliates and their respective Representatives not to, hold any such person liable with respect thereto (whether in warranty, contract, tort (including negligence or strict
liability) or otherwise). 
 (d) Purchaser, its affiliates and their respective Representatives acknowledge that any dispute regarding
Section 3.08 (API), Seller reserves the right to perform its own API testing. Should there be any disputes regarding the API test results, both parties agree to contract with an independent third party laboratory to perform the API testing.
Both parties agree to accept test result as provided by the third party laboratory. 
 ARTICLE V 

COVENANTS 
 SECTION 5.01.
Access to Information. (I) Notwithstanding anything herein (including Section 1.01 and Section 1.02(a)) to the contrary, as soon as practicable following the Closing Date, Seller shall use commercially reasonable efforts to
provide to Purchaser copies of (i) the Regulatory Approvals, and (ii) the Commingled Documents, if any, in the categories set forth in Section 5.01(i) of the Seller Disclosure Schedule, in the case of each of clauses (i) and
(ii), redacted to exclude information or data related to products owned or licensed by third parties (including Hikma, Seller or their respective affiliates and excluding Purchaser or affiliates of Purchaser) and not included within the Transferred
Assets (such information or data, “Third Party Information”). Following the Closing, upon the reasonable request of Purchaser therefor, Seller shall (x) use commercially reasonable efforts to provide to Purchaser copies of the
Commingled Documents, if any, in the categories set forth in Section 5.01(ii) or the categories set forth in Section 5.01(iii) of the Seller Disclosure Schedule, redacted with respect to all Third Party Information or (y) to the extent
reasonably required by Purchaser in connection with (A) any pending Proceeding (including any Proceeding before the United States Patent and 

 
Trademark Office and any successor agency thereto, or the equivalent entity in other countries or regulatory jurisdictions) or (B) complying with requirements of any Governmental Entity, use
commercially reasonable efforts to arrange for Hikma to grant Purchaser reasonable access to, the portions of the Commingled Documents, if any, in the categories set forth in Section 5.01(iii) of the Seller Disclosure Schedule that contain
information regarding any Product acquired by Purchaser pursuant to this Agreement (such information, the “Purchaser Commingled Information”). Any such access shall be subject to confidentiality restrictions equivalent to those set
forth in Section 5.02. In the event that Purchaser exercises its right to access Commingled Documents hereunder, Purchaser shall assume all liability for any disclosure or use of the information other than Purchaser Commingled Information (such
other information, the “Seller Commingled Information”) contained therein and any and all loss, damage, destruction or alteration of such Commingled Documents arising from the use or possession of such Commingled Documents by
Purchaser or its Representatives. For clarity, this Section 5.01 shall not provide either party hereto or any of their respective affiliates with any rights to use or disclose any information contained within any Commingled Documents not
otherwise retained or obtained pursuant to this Agreement. All requests by Purchaser for Commingled Documents shall be directed in writing to the persons set forth in Section 5.01(iv) of the Seller Disclosure Schedule (or such other persons as are
designated by Seller in writing to Purchaser). For purposes of this Section 5.01, Purchaser acknowledges and agrees that, with respect to any Commingled Documents in the possession of Hikma, Seller’s obligation to use commercially
reasonable efforts to provide Purchaser with, or access to, such Commingled Documents shall only require Seller to deliver written notice to Hikma requesting access to such Commingled Documents. (II) Any language in this Section 5.01 to
the contrary notwithstanding, in all events, Seller shall be obligated to provide to Purchaser, as soon as practicable following the Closing Date, copies of (i) Regulatory Approvals, and (ii) Commingled Documents (including Purchaser
Commingled Information), that actually are in possession of Seller as of the Closing Date, in each case redacted to exclude all Third Party Information. 

SECTION 5.02. Confidentiality. 

(a) Purchaser acknowledges that the information provided to it in connection with the Acquisition and the consummation of the other
transactions contemplated by this Agreement is subject to the terms of confidentiality letter agreement between Purchaser and Seller in connection with the Acquisition, dated September 1, 2016 (the “Confidentiality Agreement”).
Effective upon, and only upon, the Closing, the Confidentiality Agreement shall terminate with respect to information relating solely to the Transferred Assets or the Assumed Liabilities; provided, however, that Purchaser acknowledges
that any and all other information provided to it by any of Seller, any of its affiliates or their respective Representatives concerning Seller or any of its affiliates (other than information to the extent relating to the Transferred Assets or the
Assumed Liabilities) shall remain subject to the terms and conditions of the Confidentiality Agreement after the Closing. 
 (b) Subject to
Section 5.03, from and after the Closing until the third anniversary of the Closing Date, Seller shall, and shall cause its affiliates to, treat as confidential and shall 

 
safeguard any and all confidential or proprietary information, knowledge and data related solely to the Transferred Assets or the Assumed Liabilities by using the same degree of care to prevent
the unauthorized use, dissemination or disclosure of such information, knowledge and data as Seller and its affiliates used with respect thereto prior to the execution of this Agreement; provided, however, that Seller and its
affiliates shall be entitled to use any such information, knowledge and data only to the extent necessary to perform their respective obligations or exercise or enforce their respective rights and remedies under this Agreement, any Ancillary
Agreement or any agreements entered into in connection with any of the foregoing. The obligations of Seller and its affiliates pursuant to this Section 5.02(b) shall not extend to any information, knowledge or data that is (i) required to be
disclosed by applicable Law, (ii) requested by a government official or (iii) except as a result of a disclosure by Seller or its affiliates after the Closing in breach of this Agreement, generally available to the public or already known
by a third party receiving such information from Seller or its affiliates. 
 SECTION 5.03. Publicity. Other than any press
release, if any, to be agreed to in writing by Purchaser and Seller to be issued following the execution of this Agreement, neither of Purchaser, on the one hand, nor Seller, on the other hand, will issue or permit any of its respective affiliates
to issue any press release, website posting or other public announcement with respect to this Agreement or the transactions contemplated hereby without the prior consent of the other party (which consent shall, if applicable, be provided as promptly
as practicable), except as may be required by Law or stock exchange rules or regulations (in which case, whichever of Purchaser or its affiliates or Seller or its affiliates, as applicable, is required to make the release or statement shall, to the
extent compliance with such Law, rules or regulations permits, allow the other reasonable time to comment on such release or statement in advance of such issuance and such other party shall provide any comments thereto as promptly as practicable);
provided, however, that (a) Purchaser, on the one hand, and Seller, on the other hand, may, following the date hereof, make internal announcements to their respective employees and affiliates that are consistent with the
parties’ prior permitted public disclosures regarding the transactions contemplated by this Agreement and (b) Seller and Purchaser may communicate with government officials, customers and suppliers regarding this Agreement and the
transactions contemplated hereby (so long as, in the case of customers and suppliers, such communications are consistent with Seller’s or Purchaser’s, as applicable, prior permitted public disclosures regarding the transactions
contemplated by this Agreement, or a communications plan agreed upon by Seller and Purchaser). 
 SECTION 5.04. Covenant Not to
Sue. Seller agrees not to object, oppose or otherwise challenge the use, in connection with the Exploitation of the Products anywhere in the world, by Purchaser and its successors, assigns, sublicensees, contractors, manufacturers, agents and
representatives of all Know-How that is controlled by Seller and its affiliates as of the Closing. 

SECTION 5.05. Insurance. From and after the Closing, Purchaser shall not, and shall cause its affiliates not to, assert any claim
against any insurance policies or practices of Seller and its affiliates or Hikma and its affiliates (including any captive insurance policies, 

 
self-insurance, surety bonds or corporate insurance policies or practices). Purchaser agrees, from and after the Closing Date, to arrange for its own insurance policies with respect to the
Transferred Assets and the Assumed Liabilities covering all periods and agrees not to seek, through any means, to benefit from any of Seller’s or its affiliates’ insurance policies which may provide coverage for claims relating in any way
to the Transferred Assets or the Assumed Liabilities. 
 SECTION 5.06. Change in Ownership Letters. Purchaser and Seller shall,
with respect to each Regulatory Approval, if applicable, file each Purchaser Change in Ownership Letter and each Seller Change in Ownership Letter, respectively, with the U.S. Food and Drug Administration (the “FDA”) as soon as
possible and in any event within 10 days after the date on which Seller provides to Purchaser a copy of the applicable Regulatory Approval underlying each such letter pursuant to and in accordance with Section 5.01. The letters filed by Seller
and Purchaser pursuant to this Section 5.06 shall comply with all aspects of 21 C.F.R. 314.72 (Change in Ownership of an Application), and such letters shall provide for transfer of title to the Regulatory Approvals for the Products to be
effective as of the Closing. 
 SECTION 5.07. Tax Covenants. 

(a) As soon as practicable after the Closing, the parties shall agree upon an allocation of the Purchase Price (plus the Assumed Liabilities,
to the extent properly taken into account under Section 1060 of the Internal Revenue Code of 1986, as amended) among the Transferred Assets in accordance with Section 1060 of the Internal Revenue Code of 1986, as amended. Seller and
Purchaser shall, and shall cause their respective affiliates to, act in accordance with such allocation in the preparation, filing and audit of any Tax Return. 

(b) Purchaser and Seller shall cooperate in timely making all filings, returns, reports and forms as may be required in connection with
Purchaser’s payment of Transfer Taxes. Seller shall, or Purchaser, as applicable, shall execute and deliver all instruments and certificates necessary to enable the other to comply with any filing requirements relating to any such Transfer
Taxes. Purchaser and Seller shall each pay fifty percent (50%) of all Transfer Taxes. 
 (c) All real property Taxes, personal property
Taxes and similar ad valorem obligations levied with respect to the Transferred Assets for a taxable period which includes (but does not end on) the Closing Date (collectively, the “Apportioned Obligations”) shall be apportioned
between Seller, on the one hand, and Purchaser, on the other hand, based on the number of days of such taxable period included in the Pre-Closing Tax Period and the number of days included in the Post-Closing
Tax Period. Seller shall be liable for the proportionate amount of such Taxes that is attributable to the Pre-Closing Tax Period and Purchaser shall be liable for the proportionate amount of such Taxes that is
attributable to the Post-Closing Tax Period. 
 (d) Purchaser agrees to retain all records relating to Taxes with respect to the Transferred
Assets for all taxable periods ending on or prior to the Closing Date until the expiration of the statutes of limitation (including any extensions thereof) for the taxable period or periods to which such records relate. Purchaser and Seller agree to
provide each other with such information and assistance as is reasonably necessary, including access to records and personnel, for the preparation of any Tax Returns or for the defense of any Tax claim or assessment, whether in connection with an
audit or otherwise. 

 ARTICLE VI 

CLOSING DELIVERABLES 

SECTION 6.01. Seller Deliverables. The obligation of Purchaser to consummate the Closing is subject to the delivery by the Seller
of executed counterparts of this Agreement and each Ancillary Agreement to which Seller is a party. 
 SECTION 6.02. Purchaser
Deliverables. The obligation of Seller to consummate the Closing is subject to the delivery of the following by the Purchaser: 
 (a)
executed counterparts of this Agreement and each Ancillary Agreement to which Purchaser is a party; and 
 (b) the Purchase Price in
accordance with the terms and conditions of Section 2.02(b). 
 ARTICLE VII 

INDEMNIFICATION; SURVIVAL 

SECTION 7.01. Indemnification by Seller. Subject to this Article VII, from and after the Closing, Seller shall indemnify Purchaser
and its affiliates and each of their respective officers, directors, employees, stockholders, agents and representatives (the “Purchaser Indemnitees”) from and against any and all losses, damages or expenses, including reasonable
third-party legal fees and expenses in connection with any Proceeding (collectively, “Losses”), to the extent arising or resulting from any of the following: 

(a) any breach of any Specified Representations and any representations and warranties set forth in Section 3.06 (Regulatory Approvals;
Compliance Arrangements), Section 3.07 (Hikma Purchase Agreement) and Section 3.08 (API); 
 (b) any breach of any covenant of
Seller contained in this Agreement; 
 (c) any Excluded Asset; and 

(d) any Retained Liability. 

SECTION 7.02. Indemnification by Purchaser. Subject to this Article VII, from and after the Closing, Purchaser shall indemnify
Seller and its affiliates and each of their respective officers, directors, employees, stockholders, agents and representatives (the “Seller Indemnitees”) from and against any and all Losses, to the extent arising or resulting from
any of the following: 
 (a) any breach of any representation or warranty of Purchaser contained in this Agreement; 

 (b) any breach of any covenant of Purchaser contained in this Agreement; 

(c) any Assumed Liability; and 

(d) the Exploitation of the Products following the Closing. 

SECTION 7.03. Indemnification Procedures. 

(a) Third Party Claims. If any party (the “Indemnified Party”) receives written notice of the commencement of any
Proceeding or the assertion of any claim by a third party or the imposition of any penalty or assessment (in each case other than with respect to Taxes) for which indemnity may be sought under Section 7.01 or Section 7.02 (a “Third
Party Claim”), and such Indemnified Party intends to seek indemnity pursuant to this Article VII, the Indemnified Party shall promptly (but no later than 30 days of receiving such notice) provide the other party (the “Indemnifying
Party”) with written notice of such Third Party Claim, stating the nature, basis, the amount (to the extent known or estimated, which amount shall not be conclusive of the final amount of such Third Party Claim) and a reasonable description
of any other material details thereof. Failure of the Indemnified Party to give such notice will not relieve the Indemnifying Party from its indemnification obligations hereunder, except to the extent that the Indemnifying Party is actually
prejudiced thereby. The Indemnifying Party will have 20 days from receipt of any such notice of a Third Party Claim to give notice to the Indemnified Party whether it is assuming and controlling the defense, appeal or settlement proceedings thereof
with counsel of the Indemnifying Party’s choice; provided, however, that the Indemnifying Party shall not have the right to assume the defense of any Third Party Claim to the extent (but only to the extent) such Third Party Claim
(i) relates to any actual or alleged criminal proceeding, action, indictment, allegation or investigation or (ii) seeks an injunction or equitable relief against the Indemnified Party that is not merely ancillary to the principal damages
sought in the relevant claim. So long as the Indemnifying Party or the Indemnified Party, as applicable, has assumed the defense, appeal or settlement proceedings of the Third Party Claim in accordance herewith, (1) the other such party may
retain separate co-counsel at the controlling party’s cost and expense and participate in (but not control) the defense, appeal or settlement proceedings of the Third Party Claim, (2) the controlling
party will not admit any liability, file any papers or consent to the entry of any judgment or enter into any settlement agreement, compromise or discharge with respect to the Third Party Claim without the prior written consent of the other such
party and (3) the controlling party will not admit to any wrongdoing by the other such party. The controlling party shall have the right to settle any Third Party Claim for which it obtains a full release of the other such party with respect to
such Third Party Claim or to which settlement the Indemnified Party consents in writing (such consent not to be unreasonably withheld, conditioned or delayed). The parties will act in good faith in responding to, defending against, settling or
otherwise dealing with Third Party Claims. The parties will also cooperate in any such defense, appeal or settlement proceedings, and give each other reasonable access to all 

 
information relevant thereto. Whether or not the Indemnifying Party has assumed the defense, appeal or settlement proceedings with respect to a Third Party Claim, such Indemnifying Party will not
be obligated to indemnify the Indemnified Party hereunder for any settlement entered into or any judgment that was consented to without the Indemnifying Party’s prior written consent (such consent not to be unreasonably withheld, conditioned or
delayed). The party assuming such defense, appeal or settlement proceedings shall keep the other party reasonably advised of the status of such Third Party Claim and the defense thereof and shall reasonably consider recommendations made by the other
party with respect thereto. 
 (b) Other Claims. An Indemnified Party shall give the Indemnifying Party written notice of any matter
that an Indemnified Party has determined has given or could give rise to a right of indemnification under this Agreement, within 30 days of such determination, stating the amount of the Loss, if known, and the method of computation thereof, and
containing a reference to the provisions of this Agreement in respect of which such right of indemnification is claimed or arises. It is the express intention of the parties that the indemnification provided for in this Article VII shall apply to
direct claims between the parties for a breach of this Agreement (whether or not involving a third party). 
 SECTION 7.04.
Limitations on Indemnification. Notwithstanding anything to the contrary contained in this Agreement, (i) Seller’s aggregate maximum liability under Section 7.01(a) shall not exceed an amount equal to the Purchase Price with
exception of Section 3.08 (API), Seller’s aggregate maximum liability under 3.08 (API) shall not exceed $612,000; (ii) no party shall have any liability for an otherwise indemnifiable Loss that is contingent unless and until such
contingent Loss becomes an actual Loss of the Indemnified Party and is due and payable, so long as the claim for such Loss was timely submitted pursuant to the provisions of this Article VII; (iii) no party shall be liable for any Losses to the
extent the Purchaser Indemnitees or the Seller Indemnitees, as applicable, failed to mitigate such Losses in accordance with applicable Laws; (iv) no party shall be liable for any Loss to the extent arising from any Law not in force on the
date hereof or any change in Law which takes effect retroactively and (v) no party shall be liable for any otherwise indemnifiable Loss arising out of any breach of any representation, warranty, covenant or agreement of such party unless a
claim therefor is asserted with specificity and in writing by the Indemnified Party timely in accordance with Section 7.08, failing which such claim shall be waived and extinguished. The waiver of any condition to the Closing based on the
accuracy of any representation or warranty or on the performance of or compliance with any covenant or agreement shall be deemed a waiver of the right to indemnification under this Article VII with respect to such representation or warranty,
covenant, agreement or obligation. Notwithstanding any implication to the contrary contained in this Agreement, the limits on indemnification set forth in this Agreement shall not apply to any claims or Losses based on fraud or intentional
misrepresentation. 
 SECTION 7.05. Calculation of Indemnity Payments. 

(a) The amount of any Loss for which indemnification is provided under this Article VII shall be net of any amounts actually recovered by the Indemnified
Party with respect to such 

 
Loss (including payments under insurance policies net of all increases in premiums and other costs of such insurance policies for pursuing a claim thereunder). For Section 3.08 (API),
calculation of loss is based on the quantity of APIs that is unusable, which is unexpired as of the Testing Date, with payment of $0.48 per grams for Acyclovir and $25.50 per gram for Prochlorperazine Edisylate. 

(b) If an Indemnified Party recovers an amount from a third party (including payments under insurance policies) in respect of Losses that are
the subject of indemnification hereunder after all or a portion of such Losses have been paid by an Indemnifying Party pursuant to this Article VII, then the Indemnified Party shall promptly remit to the Indemnifying Party the amount received by the
Indemnified Party in respect thereof (up to the amount paid by the Indemnifying Party in respect of such Losses but net of any increase in premiums paid or other costs incurred in connection with the recovery of such proceeds). 

(c) Each party shall, and shall cause its respective affiliates to, take all commercially reasonable steps to mitigate any Loss indemnifiable
hereunder upon and after becoming aware of any event that could reasonably be expected to give rise to any Loss. No party shall be entitled to any payment, adjustment or indemnification more than once with respect to the same matter. 

SECTION 7.06. Exclusive Remedy. From and after the Closing, subject to Section 1.01(b) and Section 8.15, Purchaser’s
sole and exclusive remedy with respect to any and all claims relating to this Agreement, the Transferred Assets, the Assumed Liabilities or the transactions contemplated by this Agreement shall be pursuant to the indemnification provisions set forth
in this Article VII. In furtherance of the foregoing, Purchaser hereby waives, from and after the Closing, any and all rights, claims and causes of action whether based on warranty, in contract, in tort (including negligence or strict liability) or
otherwise that Purchaser or any other Purchaser Indemnitee may have against Seller, any of its affiliates or any other person, arising under or based upon any Law, except pursuant to the indemnification provisions set forth in this Article VII.
Notwithstanding anything to the contrary contained in this Agreement, no breach of any representation, warranty, covenant or agreement contained herein shall, after the consummation of the transactions contemplated by this Agreement, give rise to
any right on the part of Purchaser, on the one hand, or Seller, on the other hand, to rescind this Agreement or any of the transactions contemplated hereby. No past, present or future Representative, incorporator, member, partner or stockholder of
Seller or any of its affiliates shall have any liability, whether based on warranty, in contract, in tort (including negligence or strict liability) or otherwise, for any obligations or liabilities of Seller or any of its affiliates arising under,
in connection with or related to this Agreement or for any claim based on, in respect of or by reason of the Acquisition, including any alleged non-disclosure or misrepresentations made by any such persons.
Notwithstanding anything to the contrary contained in this Agreement, nothing in this Agreement shall limit the rights, remedies or claims of any party based on fraud or intentional misrepresentation by any other party. 

 SECTION 7.07. Tax Treatment of Indemnification. For all Tax purposes, Purchaser and
Seller agree to treat any adjustments to amounts paid under this Agreement and any indemnity payment under this Agreement as an adjustment to the Purchase Price unless a final determination of a Taxing Authority (which shall include the execution of
an IRS Form 870-AD or successor form or an HMRC Enquiry Closure Notice form) provides otherwise. 

SECTION 7.08. Survival. All representations and warranties contained in this Agreement, and all claims with respect thereto shall
terminate at Closing; provided, however, that (i) Seller’s representations and warranties set forth in Section 3.06 (Regulatory Approvals; Compliance Arrangements), Section 3.07 (Hikma Asset Purchase Agreement),
Section 3.08 (API) shall terminate at the close of business on the date that is one year following the Closing Date, and (ii) the Specified Representations and the representations and warranties set forth in Section 4.01
(Organization), Section 4.03 (Authority; Execution and Delivery; Enforceability) and Section 4.05 (Brokers and Finders), shall survive indefinitely; provided, further that the covenants or agreements contained in this
Agreement which by their terms contemplate performance after the Closing Date shall survive the Closing only until the expiration of the term of the undertaking set forth in such agreements and covenants. After the Closing, no party shall have any
liability or obligation of any nature with respect to any representation, warranty, agreement or covenant after the termination thereof, with the exception of payment of the Purchase Price, unless a notice of a breach thereof giving rise to a right
of indemnity shall have been given to the party against whom such indemnity may be sought prior to such time, in which case the representation, warranty, covenant or agreement which is the subject of such claim shall survive, to the extent of the
claims described in the notice only, until such claim is resolved, whether or not the amount of the Losses resulting from such breach has been finally determined at the time the notice is given. 

SECTION 7.09. No Setoff Rights. Neither party shall have any right of setoff of any amounts due and payable, or any Liabilities
arising, under this Agreement, any Ancillary Agreement or any other agreement entered into by the parties or their respective affiliates against any other amounts due and payable, or any other Liabilities arising, under this Agreement, any Ancillary
Agreement or any other agreement entered into by the parties or their respective affiliates. The payment obligations under each of this Agreement and the Ancillary Agreements remain independent obligations of each party, irrespective of any amounts
owed to any other party under this Agreement, the respective Ancillary Agreements or any other agreement entered into by the parties or their respective affiliates. 

 ARTICLE VIII 

MISCELLANEOUS 

SECTION 8.01. Assignment. Seller may assign any of its rights and obligations hereunder (i) to any of its affiliates;
provided that Seller, as applicable, shall remain primarily liable for all of its obligations hereunder and (ii) to a third party in connection with a sale or transfer (by means of a merger, stock sale or otherwise) of all or
substantially all of Seller’s business and Purchaser may assign its rights and obligations hereunder (i) to any of its affiliates; and (ii) to a third party in connection with a sale or transfer (by means of a merger, stock sale or
otherwise) of all or substantially all of Purchaser’s business, subject to applicable Law, provided that in each instance Purchaser shall remain primarily liable for all of its obligations hereunder. This Agreement shall be binding upon
and inure to the benefit of the parties hereto and their respective successors and permitted assigns. Any attempted assignment or transfer in violation of this Section 8.01 shall be null and void. 

SECTION 8.02. No Third-Party Beneficiaries. Except as provided in Section 5.01 and Article VII, this Agreement is for the
sole benefit of the parties hereto and their respective successors and permitted assigns and nothing herein expressed or implied shall give or be construed to give to any person, other than the parties hereto and such successors and assigns, any
legal or equitable rights hereunder. 
 SECTION 8.03. Expenses. Whether or not the Closing occurs, each of the parties shall pay
its own legal, accounting and other fees and expenses incurred in connection with the preparation, execution and delivery of this Agreement and all documents and instruments executed pursuant hereto and the consummation of the transactions
contemplated hereby and any other costs and expenses incurred by such party, except as otherwise expressly set forth herein. 

SECTION 8.04. Notices. All notices, requests, permissions, waivers and other communications hereunder shall be in writing and
shall be deemed to have been duly given (a) five Business Days following sending by registered or certified mail, postage prepaid, (b) when delivered, if delivered personally to the intended recipient and (c) one Business Day
following sending by overnight delivery via a national courier service and, in each case, addressed to a party at the following address for such party: 
  

			
	(i)	  	if to Seller,
		
		  	Amphastar Pharmaceuticals, Inc.
		  	11570 6th Street
		  	Rancho Cucamonga, CA 91730
		  	Attention: General Counsel
		  	Attention: Sr. Vice President of Corporate Administration Center

			
	(ii)	  	if to Purchaser,
		
		  	Athenex, Inc.
		  	Conventus Building
		  	1001 Main Street
		  	Suite 600
		  	Buffalo, NY 14203
		  	Attention: Teri Bair, Senior VP of Corp. Development & Legal Affairs,

 or to such other address(es) as shall be furnished in writing by any such party to the other party hereto in accordance with
the provisions of this Section 8.04. 
 SECTION 8.05. Interpretation; Certain Definitions. 

(a) Any matter set forth in any provision, subprovision, Section or subsection of the Seller Disclosure Schedule shall be deemed to
be disclosed for each other provision, subprovision, Section or subsection of the Seller Disclosure Schedule to the extent it is reasonably apparent from the face of such disclosure that such disclosure is applicable to such other provision,
subprovision, Section or subsection of the Seller Disclosure Schedule. Inclusion of a reference to or disclosure of any matter or item in this Agreement or in the Seller Disclosure Schedule (i) shall not be construed as an admission or
indication that such matter or item is material or that such matter or item is required to be referred to or disclosed, nor shall it be deemed to establish a standard of materiality now or in the future (it being the intent that neither Seller,
Purchaser nor any of their respective affiliates, as applicable, shall be penalized for having disclosed more than may be required by the request); (ii) does not represent a determination by Seller, Purchaser or any of their respective affiliates,
as applicable, that such matter or item did not arise in the ordinary course; (iii) shall not imply that such matter or item constitutes or would constitute a Material Adverse Effect by the criteria set forth in this Agreement and
(iv) shall not imply that disclosure of such matter or item is required by Law or by any Governmental Entity. Without limiting the foregoing, no such reference to or disclosure of a possible breach or violation of any Contract, Law or Judgment
shall be construed as an admission or indication that a breach or violation exists or has actually occurred. All Exhibits annexed hereto or referred to herein, and the Seller Disclosure Schedule, are hereby incorporated in and made a part of this
Agreement as if set forth in full herein. Any term used in the Seller Disclosure Schedule, or in any Exhibit but not otherwise defined therein, shall have the meaning assigned to such term in this Agreement, if any. References to defined terms in
the singular shall include the plural and references to defined terms in the plural shall include the singular. “Extent” in the phrase “to the extent” means the degree to which a subject or other thing extends, and such phrase
does not mean simply “if.” The descriptive headings of the several Articles and Sections of this Agreement, the Table of Contents to this Agreement and the Seller Disclosure Schedule are inserted for convenience only, do not
constitute a part of this Agreement and shall not affect in any way the meaning or interpretation of this Agreement. All references herein to “Articles,” “Sections,” “Exhibits” or “Schedules” shall be deemed
to be references to Articles or Sections hereof or Exhibits or Schedules hereto unless otherwise indicated. The terms “hereof,” “herein,” “hereby” and derivative or similar words refer to this entire Agreement.
References (x) 

 
to any statute shall be deemed to refer to such statute as amended from time to time and to any rules or regulations promulgated thereunder and (y) to any Contract are to that Contract as
amended, modified or supplemented from time to time in accordance with the terms hereof and thereof. Except where the context otherwise requires, wherever used, the word “or” is used in the inclusive sense (and/or). Any references in this
Agreement to dollars, or to $ are expressed in the currency of the United States. 
 (b) For all purposes hereof: 

“affiliate” means, with respect to any party, any person or entity controlling, controlled by or under common control with
such party; provided that, for the avoidance of doubt, the term “affiliate” shall not include the shareholders of (i) Purchaser or (ii) Seller. For purposes of this definition, “control” means, with
respect to any entity, the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such entity, whether through the ownership of voting securities (or other ownership interest), by contract
or otherwise. 
 “ANDA” means an abbreviated new drug application submitted in accordance with Section 505(j) of the
Federal Food, Drug and Cosmetic Act. 
 “Business Day” means any day, other than a Saturday or a Sunday, on which
commercial banks are not required or authorized to remain closed in New York City. 
 “Claim” means any claims, demands,
actions, suits and causes of action, whether class, individual or otherwise in nature, in law or in equity. 
 “Commingled
Documents” means Transferred Books and Records (other than Regulatory Approvals) within the categories listed in Section 5.01 of the Seller Disclosure Schedule that include both (i) information or data related to Transferred
Assets and (ii) Third Party Information. 
 “Contract” means any contract, agreement, lease, sublease, license,
commitment, franchise, understanding, arrangement, bond, debenture, note, mortgage, indenture, guarantee, purchase order, term sheet, or other legally binding instrument, whether written or oral. 

“Exploit” means to make, have made, import, export, use, have used, sell, offer for sale, have sold, research, develop
(including seeking, obtaining and maintaining Regulatory Approval), commercialize, hold or keep (whether for disposal or otherwise), transport, distribute, promote, market, or otherwise dispose of and Manufacture or have Manufactured.
“Exploitation” has a corresponding meaning. 
 “Governmental Entity” means any federal, national,
supranational, state, provincial, local, foreign or administrative court of competent jurisdiction, governmental agency, authority, instrumentality or regulatory body. 

“including” (and, with correlative meaning, “include”) means including, without limiting the generality of
any description preceding or succeeding such term, and the rule of ejusdem generis will not be applicable to limit a general statement preceded, followed by or referable to an enumeration of specific matters, to matters similar to
those specifically mentioned. 

 “Intellectual Property” means all (i) patents and patent applications,
including divisionals, continuations, continuations-in-part, renewals, extensions, reissues and reexaminations; (ii) trademarks, trade names, logos, service marks,
and other indicia of origin, all registrations and applications for any of the foregoing, and all goodwill associated therewith and symbolized thereby, including all renewals of same; (iii) Know-How,
including Trade Secrets that are the subject of efforts that are reasonable under the circumstances to maintain their secrecy; (iv) published and unpublished original works of authorship (including software and data compilations to the extent
it constitutes an original work of authorship) fixed in any tangible media, and registrations and applications therefor, and any copyrights with respect thereto and all renewals, extensions, restorations and reversions thereof, database rights and
moral rights; (v) rights of publicity and privacy; (vi) Internet domain names; and (vii) any other domestic, state and foreign intellectual property rights (including industrial property rights) to the extent entitled to legal
protection as such. 
 “Know-How” means all inventions, Trade Secrets, discoveries,
know-how, data, information (including scientific, technical or regulatory information), processes, means, methods, practices, formulae, instructions, procedures, techniques, materials, technology, results,
analyses, designs, drawings, computer programs, specifications, technical assistance, in written, electronic or any other form, whether or not patentable, including any such Know-How that relates to
Manufacturing of the Products. 
 “made available” means, with respect to any document, that such document was delivered to
Purchaser or its Representatives by any of Seller or its affiliates or Representatives prior to the date hereof. 

“Manufacture” means all activities related to the production, manufacture, processing, filling, finishing, packaging,
labeling, shipping and holding (prior to distribution) and distribution of any of the Products or any intermediate thereof, including process development, process qualification and validation, scale-up,
commercial manufacture and analytic development, product characterization, stability testing, quality assurance and quality control. 

“Net Sales” means the gross invoiced sales of the Products from Transferred Assets to all customers less
(i) chargebacks; (ii) trade discounts, credits or allowances; (iii) costs of replacements, returns, recalls or rebates (including but not limited to group purchasing organization fees and rebates); (iv) discounts or rebates or other
payments required by law to be made under Medicaid, Medicare or other governmental special medical assistance programs (v) wholesaler service charges; (vi) sales, excise or value added taxes paid on or in relation to sales of the Products,
all as calculated in accordance with US GAAP; and (vii) two percent (2%) of the Net Sales price representing the overhead attributable to marketing and selling the Products. 

“NDA” means a New Drug Application, and any amendments or supplements thereto, filed with the FDA pursuant to its rules and
regulations. 
 “Permitted Liens” means (i) such Liens as are set forth in Section 8.05(b)(ii) of the Seller
Disclosure Schedule, (ii) mechanics’, materialmen’s, carriers’, workmen’s, repairmen’s or other like Liens arising or incurred in the ordinary course of Seller’s business relating to obligations as to which there
is no default on the part of Seller or the validity or amount of which is being 

 
contested in good faith through appropriate proceedings, (iii) Liens arising under original purchase price conditional sales Contracts and equipment leases with third parties entered into in
the ordinary course of Seller’s business, (iv) Liens for Taxes and other governmental charges that are not due and payable or being contested in good faith, (v) recorded or unrecorded easements, covenants, restrictions, rights-of-way, zoning, building restrictions and other similar matters, (vi) licenses and options relating to Intellectual Property granted in the ordinary course of
Seller’s business and (vii) such imperfections of title, licenses or Liens, if any, which do not materially impair the continued use and operation or value of the Transferred Assets. 

“person” means any individual, firm, corporation, partnership, limited liability company, trust, joint venture, Governmental
Entity or other entity. 
 “Post-Closing Tax Period” means all taxable periods beginning on or after the Closing Date and
the portion beginning on the Closing Date of any tax period that includes but does not end on the day prior to the Closing Date. 

“Pre-Closing Tax Period” means all taxable periods ending prior to the Closing Date
and the portion ending on the day prior to the Closing Date of any taxable period that includes but does not end on the day prior to the Closing Date. 

“Product” means any of the products set forth in Section 8.05(b)(iii) of the Seller Disclosure Schedule. 

“Purchaser Change in Ownership Letters” means the letters to the FDA substantially in the form of Exhibit B, accepting the
transfer of rights to the Regulatory Approvals, if applicable, from Seller. 
 “Representatives” means, with respect to a
person, such person’s directors, officers, employees, investment bankers, financial advisors, attorneys, accountants or other advisors, agents or representatives. 

“Seller Change in Ownership Letters” means the letters to the FDA substantially in the form of Exhibit C, transferring the
rights to the Regulatory Approvals, if applicable, to Purchaser. 
 “Specified Representations” means the representations
and warranties of Seller set forth in Section 3.01 (Organization and Standing), Section 3.02 (Authority; Execution and Delivery; Enforceability) and Section 3.04 (Title to Assets). 

“Subsidiary” of any person means another person, an amount of the voting securities, other voting ownership or voting
partnership interests of which is sufficient to elect at least a majority of its Board of Directors or other governing body (or, if there are no such voting interests, 50% or more of the equity interests of which) is owned directly or indirectly by
such first person or by another subsidiary of such first person. 
 “Tax” means all forms of taxation, including any
interest or penalties that may become payable in respect thereof, imposed by any federal, national, supranational, state, provincial, local, foreign or other Taxing Authority, including income, franchise, gross receipts, occupation, real and
personal property, stamp, sales, use, excise, profits, capital, net worth, employment, 

 
unemployment, payroll, social security, estimated, value added, ad valorem, custom duties, transfer, recapture, withholding, workers’ compensation, occupancy, health and other taxes or
obligations of the same or of a similar nature, and shall include any liability for such amounts whether as a primary obligor or as a result of being a transferee or successor of another person or as a result of either being a member of a combined,
consolidated, unitary or affiliated group or of a contractual obligation to indemnify any person or other entity. 
 “Tax
Return” means any report, return, document, declaration or other information or filing required to be supplied to any Taxing Authority with respect to Taxes, including any amendment made with respect thereto. 

“Taxing Authority” means any federal, national, supranational, state, provincial, local or foreign government, any
subdivision, agency, commission or authority thereof or any quasi-governmental body exercising tax regulatory authority. 
 “Trade
Secrets” means information that derives independent economic value from not being generally well known to, and not being readily ascertainable by proper means by, other persons who can obtain economic value from its disclosure or use,
including confidential or proprietary information including customer, supplier, vendor and distributor lists and related data, invention disclosures, discoveries, lab notebooks or journals. 

“Transfer Taxes” means all sales, use, transfer, recording, value added, ad valorem, privilege, documentary, gross receipts,
registration, conveyance, excise, license, stamp or similar fees and Taxes arising out of, in connection with or attributable to the transactions effectuated pursuant to this Agreement. 

SECTION 8.06. Limitation on Damages. Notwithstanding anything to the contrary contained in this Agreement, in no event shall
either party be liable for special, indirect, incidental, exemplary, punitive or consequential damages of the other party (including for lost or anticipated profits, revenues or opportunities, diminution in value or business interruption), or for
any damages calculated by reference to a multiplier of revenue, profits, EBITDA or similar methodology (provided, that, in any case, damages payable to a third party shall constitute direct damages notwithstanding the characterization of such
damages vis-à -vis the third party) whether or not caused by or resulting from the actions of such party or the breach of its covenants, agreements,
representations or warranties hereunder and whether or not based on or in warranty, contract, tort (including negligence or strict liability) or otherwise. 

SECTION 8.07. Counterparts. This Agreement may be executed in one or more counterparts, all of which shall be considered one and
the same agreement, and shall become effective when each party hereto shall have received counterparts hereof signed by each of the other parties hereto. If any signature is delivered by facsimile transmission or by PDF, such signature shall create
a valid and binding obligation of the party executing (or on whose behalf the signature is executed) with the same force and effect as if such facsimile or PDF signature were an original thereof. 

SECTION 8.08. Entire Agreement. This Agreement, and the Exhibits and Seller Disclosure Schedule annexed hereto, the
Confidentiality Agreement and the Ancillary 

 
Agreements constitute the entire understanding between the parties with respect to the subject matter hereof and thereof, and supersede all other understandings, negotiations, discussions,
conversations and writings with respect thereto. The parties agree to define their rights, liabilities and obligations with respect to such understanding and the transactions contemplated hereby exclusively in contract pursuant to the express terms
and provisions of this Agreement, and the parties expressly disclaim that they are owed any duties or are entitled to any remedies not expressly set forth in this Agreement. In the event of any conflict between the provisions of this Agreement
(including the Seller Disclosure Schedule and Exhibits), on the one hand, and the provisions of the Confidentiality Agreement or the Ancillary Agreements (including the schedules and exhibits thereto), on the other hand, the provisions of this
Agreement shall control. 
 SECTION 8.09. Severability. In the event that any provision contained in this Agreement shall for
any reason be held to be invalid, illegal or unenforceable in any jurisdiction, such provision shall be ineffective as to such jurisdiction to the extent of such invalidity, illegality or unenforceability without invalidating or affecting the
remaining provisions hereof or affecting the validity, legality or enforceability of such provision in any other jurisdiction. Upon such a determination, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the
original intent of the parties hereto as closely as possible in a reasonably acceptable manner in order that the transactions contemplated hereby may be consummated as originally contemplated to the fullest extent possible. 

SECTION 8.10. Governing Law. This Agreement, the negotiation, execution or performance of this Agreement and any disputes arising
under or related hereto (whether for breach of contract, tortious conduct or otherwise) shall be governed and construed in accordance with the Laws of the State of Delaware, without reference to its conflicts of law principles that would refer the
construction of or resolution of any dispute under this Agreement to the substantive Laws of another jurisdiction. 
 SECTION 8.11.
Jurisdiction. Each party irrevocably agrees that, subject to Section 1.01(b) and Section 8.15, any Proceeding against them arising out of or in connection with this Agreement or the transactions contemplated hereby or disputes relating
hereto (whether for breach of contract, tortious conduct or otherwise) shall be brought in the United States District Court of Delaware, and hereby irrevocably accepts and submits to the jurisdiction and venue of the aforesaid courts
in personam with respect to any such Proceeding and waives to the fullest extent permitted by Law any objection that it may now or hereafter have that any such Proceeding has been brought in an inconvenient forum. 

SECTION 8.12. Service of Process. Each of the parties consents to service of any process, summons, notice or document which may be
served in any Proceeding in the United States District Court of Delaware, which service may be made by certified or registered mail, postage prepaid, or as otherwise provided in Section 8.04, to such party’s respective address set forth in
Section 8.04. 

 SECTION 8.13. Waiver of Jury Trial. Each party hereby waives, to the fullest
extent permitted by Law, any right it may have to a trial by jury in respect to any litigation directly or indirectly arising out of, under or in connection with this Agreement or any Ancillary Agreement or the transactions contemplated hereby or
thereby or disputes relating hereto or thereto. Each party (a) certifies that no representative, agent or attorney of any other party has represented, expressly or otherwise, that such other party would not, in the event of litigation, seek to
enforce the foregoing waiver and (b) acknowledges that it and the other party hereto have been induced to enter into this Agreement by, among other things, the mutual waivers and certifications in this Section 8.13. 

SECTION 8.14. Amendments and Waivers. This Agreement may be amended, modified, superseded or canceled and any of the terms,
covenants, representations, warranties or conditions hereof may be waived only by an instrument in writing signed by each of the parties or, in the case of a waiver, by or on behalf of the party waiving compliance. No course of dealing between the
parties shall be effective to amend or waive any provision of this Agreement. 
 SECTION 8.15. Specific Performance. The parties
agree that irreparable damage would occur in the event that the parties do not perform their obligations under the provisions of this Agreement in accordance with its specified terms or otherwise breach such provisions. The parties acknowledge and
agree that (a) the parties shall be entitled to an injunction or injunctions, specific performance or other equitable relief to prevent breaches of this Agreement and to enforce specifically the terms and provisions hereof in any court of
competent jurisdiction without proof of damages or otherwise, this being in addition to any other remedy to which they are entitled under this Agreement and (b) the right of specific enforcement is an integral part of the transactions
contemplated by this Agreement and without that right, neither Seller nor Purchaser would have entered into this Agreement. The parties agree not to assert that a remedy of specific enforcement is unenforceable, invalid, contrary to Law or
inequitable for any reason, and not to assert that a remedy of monetary damages would provide an adequate remedy or that the parties otherwise have an adequate remedy at law. The parties hereto acknowledge and agree that any party seeking an
injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement in accordance with this Section 8.15 shall not be required to provide any bond or other security in
connection with any such order or injunction. 
 SECTION 8.16. Joint Drafting. The parties hereto have been represented by
counsel in the negotiations and preparation of this Agreement; therefore, this Agreement will be deemed to be drafted by each of the parties hereto, and no rule of construction will be invoked respecting the authorship of this Agreement. 

SECTION 8.17. Fulfillment of Obligations. Any obligation of any party to any other party under this Agreement or any of the
Ancillary Agreements, which obligation is performed, satisfied or fulfilled completely by an affiliate of such party, shall be deemed to have been performed, satisfied or fulfilled by such party. 

 IN WITNESS WHEREOF, Seller and Purchaser have duly executed this Agreement as of the date first
written above. 
  

			
	ATHENEX, INC.
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	AMPHASTAR PHARMACEUTICALS, INC.
		
	By:	 	  

		 	Name:
		 	Title:

 SIGNATURE PAGE 

ASSET PURCHASE AGREEMENT 

 SELLER DISCLOSURE SCHEDULE TO 

ASSET PURCHASE AGREEMENT 

            , 2017 

The attached disclosure schedule (this “Seller Disclosure Schedule”) constitutes the Seller Disclosure Schedule referred to
in the Asset Purchase Agreement (the “Agreement”) dated as of             , 2017, between Athenex Inc., a Delaware corporation (“Purchaser”) and Amphastar
Pharmaceuticals, Inc., a Delaware corporation (“Seller”). Any term used in this Seller Disclosure Schedule and not otherwise defined herein shall have the meaning assigned to such term in the Agreement, if any. All references to
section numbers contained in this Seller Disclosure Schedule refer to sections of the Agreement, unless the context otherwise requires. 

This Seller Disclosure Schedule is qualified in its entirety by reference to specific provisions of the Agreement, and is not intended to
constitute, and shall not be construed as constituting, representations, warranties, covenants or agreements of Seller or any of its affiliates except as and to the extent provided in the Agreement. Any matter set forth in any provision,
subprovision, section or subsection of this Seller Disclosure Schedule shall be deemed to be disclosed for each other provision, subprovision, section or subsection of this Seller Disclosure Schedule to the extent it is reasonably apparent from the
face of such disclosure that such disclosure is applicable to such other provision, subprovision, section or subsection of this Seller Disclosure Schedule. This Seller Disclosure Schedule and the information and disclosures contained herein are
intended only to qualify the representations, warranties and covenants of Seller contained in the Agreement, and in no event shall the listing of such matters in this Seller Disclosure Schedule be deemed or interpreted to broaden or otherwise
amplify such representations, warranties or covenants. Inclusion of a reference to or disclosure of any matter or item in this Seller Disclosure Schedule (i) shall not be construed as an admission or indication that such matter or item is
material or that such matter or item is required to be referred to or disclosed, nor shall it be deemed to establish a standard of materiality now or in the future (it being the intent that neither Seller nor any of its affiliates shall be penalized
for having disclosed more than may be required by the request); (ii) does not represent a determination by Seller or any of its affiliates that such matter or item did not arise in the ordinary course; (iii) shall not imply that such matter or
item constitutes or would result in a Material Adverse Effect by the criteria set forth in the Agreement and (iv) shall not imply that disclosure of any such matter or item is required by Law or by any Governmental Entity. Without limiting the
foregoing, no such reference to or disclosure of a possible breach or violation of any Contract, Law or Judgment shall be construed as an admission or indication that a breach or violation exists or has actually occurred. The information contained
in this Seller Disclosure Schedule is disclosed solely for the purposes of the Agreement, and no information contained in this Seller Disclosure Schedule shall be deemed to be an admission by Seller to any third party of any matter whatsoever. In
disclosing this information, Seller expressly does not waive any attorney client privilege associated with such information or any protection afforded by the work product doctrine with respect to any of the matters disclosed or discussed herein.

 Matters reflected in this Seller Disclosure Schedule are not necessarily limited to matters
required by the Agreement to be reflected herein. To the extent any such additional matters are included, they are included for information purposes and do not necessarily include other matters of a similar nature. 

The descriptive headings of the several sections of this Seller Disclosure Schedule are inserted for convenience only, do not constitute a
part of this Seller Disclosure Schedule and shall not affect in any way the meaning or interpretation of this Seller Disclosure Schedule. The contents of all schedules, annexes and attachments to this Seller Disclosure Schedule are incorporated by
reference in this Seller Disclosure Schedule as though fully set forth in this Seller Disclosure Schedule. 
 The information contained in
this Seller Disclosure Schedule is confidential information of Seller, and Purchaser and its respective affiliates are obligated to maintain and protect such information pursuant to the Agreement and the Confidentiality Agreement. 

 Section 1.02(a)(i) 

Transferred Books and Records 

Quality/Production Data 
  

	1.	Annual stability report and any associated OOS/OOT 

  

	2.	API specific analytical methods 

  

	3.	General test methods 

  

	4.	Process validation reports 

  

	5.	Container Closure Integrity Test reports 

  

	6.	Annual Product Review 

  

	7.	Product Quality Assessment, if applicable 

  

	8.	Final Product Certificate of Analysis 

  

	9.	Executed batch records 

  

	10.	Master batch records template 

  

	11.	API specifications 

  

	12.	Non compendia excipients specifications, analytical methods and analytical methods validations, if available 

Regulatory Data 
  

	1.	All official ANDA documentation (Vol. A correspondence, original application, amendments, supplements, etc.) and electronic submission sequences 

 

	2.	Active pharmaceutical ingredient DMF dossiers 

  

	3.	Product specific Field Alert Reports and Recalls, if applicable 

  

	4.	Product specific labeling files 

  

	5.	Advertising/promotion record, if applicable 

  

	6.	Clinical records, if applicable 

  

	7.	Global Field Alert Reports and Recalls 

  

	8.	Labeling files and structured product labeling files 

  

	9.	Adverse events and product complaints, if applicable 

 Section 1.02(a)(ii) 

Regulatory Approvals 
  

									
	 Current

(A)NDA #
	  	 Original

(A)NDA #
	  	 Product
	  	 Strength
	  	 Marketing

Status

					
	074596	  	74-596	  	Acyclovir for Injection USP	  	500mg	  	Discontinued
					
		  		  	Acyclovir for Injection USP	  	1g	  	Discontinued
					
	074441	  	74-441	  	Bumetanide Injection USP	  	0.25mg/mL, 2mL	  	Discontinued
					
		  		  	Bumetanide Injection USP	  	0.25mg/mL, 4mL	  	Discontinued
					
		  		  	Bumetanide Injection USP	  	0.25mg/mL, 10mL	  	Discontinued
					
	074617	  	74-617	  	Diltiazem HCl Injection	  	5mg/mL, 5mL	  	Discontinued
					
		  		  	Diltiazem HCl Injection	  	5mg/mL, 10mL	  	Discontinued
					
		  		  	Diltiazem HCl Injection	  	5mg/mL, 25mL	  	Discontinued
					
	074939	  	74-939	  	Dipyridamole Injection USP	  	5mg/mL, 10mL	  	Discontinued
					
	076266	  	76-266	  	Doxapram HCl Injection USP	  	20mg/mL, 20mL	  	Discontinued

									
	 Current

(A)NDA #
	  	 Original

(A)NDA #
	  	 Product
	  	 Strength
	  	 Marketing

Status

					
	075634	  	75-634	  	Enalaprilat Injection	  	1.25mg/mL, 2mL	  	Discontinued
					
	075825	  	75-825	  	Famotidine Injection (Pharmacy Bulk; Preservative-Free)	  	10mg/mL, 50mL	  	Discontinued
					
	075684	  	75-684	  	Famotidine Injection (Pharmacy Bulk; Preserved)	  	10mg/mL, 50mL	  	Discontinued
					
	075622	  	75-622	  	Famotidine Injection (Preservative-Free)	  	10mg/mL, 2mL	  	Discontinued
					
	075651	  	75-651	  	Famotidine Injection (Preserved)	  	10mg/mL, 4mL	  	Discontinued
					
		  		  	Famotidine Injection (Preserved)	  	10mg/mL, 20mL	  	Discontinued
					
	040540	  	40-540	  	Prochlorperazine Edisylate Injection USP	  	5mg/mL, 2mL	  	Discontinued
					
		  		  	Prochlorperazine Edisylate Injection USP	  	5mg/mL, 10mL	  	Discontinued
					
	075792	  	75-792	  	Propranolol HCl Injection USP	  	1mg/mL, 1mL	  	Discontinued
					
	076770	  	76-770	  	Terbutaline Sulfate Injection USP	  	1mg/mL, 1mL	  	Discontinued
					
	076295	  	76-295	  	Valproate Sodium Injection USP	  	100mg/mL, 5mL	  	Discontinued

 Section 1.02(a)(iii) 

Inventory of the APIs 
  

															
	 Item
Number
	  	 Description
	  	 Expiry
	  	 Vendor Lot
	  	 Lot/Serial
	  	 Qty
	  	 UM

								
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	Feb-16	  	1100236	  	11-0314	  	47,991.73	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	Feb-16	  	1100236	  	11-0314	  	49,995.38	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	Feb-16	  	1100236	  	11-0314	  	49,995.38	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	Feb-16	  	1100236	  	11-0314	  	49,995.38	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	Feb-16	  	1100236	  	11-0314	  	49,995.38	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	24-Jan-17	  	1200590	  	12-0103	  	4,179.87	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	24-Jan-17	  	1200590	  	12-0103	  	49,947.41	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	24-Jan-17	  	1200590	  	12-0103	  	49,947.41	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	12-Dec-17	  	9030400	  	13-0032	  	19,982.23	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	12-Dec-17	  	9030400	  	13-0032	  	49,982.23	  	gm
	BNCH3497S	  	ACYCLOVIR USP/EP	  	Excella GmbH	  	12-Dec-17	  	9030400	  	13-0032	  	49,982.23*	  	gm
	BNCH3529	  	DILTIAZEM HCL, USP	  	FERMION (4029)INTERCHEM	  	14-Jun-15	  	1343727	  	10-0579	  	36,543.55	  	gm
	BNCH3529	  	DILTIAZEM HCL, USP	  	FERMION (4029)INTERCHEM	  	28-Feb-16	  	1386196	  	11-0238	  	20,690.63	  	gm
	BNCH3529	  	DILTIAZEM HCL, USP	  	FERMION (4029)INTERCHEM	  	28-Feb-16	  	1386196	  	11-0238	  	39,968.63	  	gm

															
	BNCH3529	  	DILTIAZEM HCL, USP 	  	FERMION (4029)INTERCHEM	  	28-Feb-16	  	1386196	  	11-0238	  	39,992.27	  	gm
	BNCH3529	  	DILTIAZEM HCL, USP 	  	FERMION (4029)INTERCHEM	  	28-Feb-16	  	1386196	  	11-0238	  	39,998.49	  	gm
	BNCH3529	  	DILTIAZEM HCL, USP 	  	FERMION (4029)INTERCHEM	  	28-Feb-16	  	1386196	  	11-0238	  	39,992.27	  	gm
	BNCH3887	  	DIPYRIDAMOLE, USP 	  	GYMA/SIMS	  	Dec-14	  	155.106	  	10-0291	  	24,688.58	  	GM
	BNCH3711	  	ENALAPRILAT, USP 	  	 Excella GmbH
	  	Nov-14	  	0911473	  	10-0236	  	1,425.86	  	GM
	BNCH3711	  	ENALAPRILAT, USP 	  	Excella GmbH	  	Nov-14	  	0911473	  	11-0002	  	733.29	  	GM
	BNCH3711	  	ENALAPRILAT, USP 	  	Excella GmbH	  	Nov-14	  	0911473	  	11-0152	  	1,483.12	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	21-Oct-12	  	F 307	  	10-0101	  	5,647.73	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	25-May-13	  	F 311	  	10-0715	  	24,846.40	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	9-Dec-13	  	F 316	  	11-0181	  	24,857.84	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	9-Dec-13	  	F 316	  	11-0181	  	24,995.60	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	9-Dec-13	  	F 316	  	11-0181	  	24,995.60	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	9-Dec-13	  	F 316	  	11-0181	  	24,995.60	  	GM
	BNCH3721	  	FAMOTIDINE 	  	GYMA/ECROS	  	9-Dec-13	  	F 316	  	11-0181	  	24,995.60	  	GM
	BNCH3951	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	July 2016	  	PROPER-ES/072/L	  	11-0531	  	4,519.75	  	GM
	BNCH3951	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	Nov 2016	  	PROPER-ES/074/L	  	11-0701	  	7,372.95	  	GM
	BNCH3951	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	Nov 2016	  	PROPER-ES/076/L	  	11-0703	  	5,460.75	  	GM

															
	 BNCH3951
	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	Nov 2016	  	 PROPER-

ES/077/L
	  	12-0005A	  	7,358.51	  	GM
	 BNCH3951
	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	 June

2018
	  	 PROPER-

ES/083/L
	  	13-0167A	  	7,300.00*	  	GM
	 BNCH3951
	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	 June

2018
	  	 PROPER-

ES/084/L
	  	13-0168	  	7,400.00*	  	GM
	 BNCH3951
	  	PROCHLORPERAZINE 	  	EDISYLATE TRIFARMA S.p.A	  	 June

2018
	  	 PROPER-

ES/085/L
	  	13-0169	  	7,062.60*	  	GM
	 BNCH3987
	  	TERBUTALINE SULFATE 	  	CAMBREX PROFRMACO MILANO	  	Jan 2015	  	220103	  	11-0392	  	1,945.58	  	GM

  

	*	Seller will keep certain amount of APIs that are not expired as of the Closing Date as “Retain Samples”, the quantity for Retain Samples will be according to the applicable United States Pharmacopeia.

 Section 1.03(a)(iv) 

Assumed Liabilities 
 It is possible that
the FDA may require that additional studies be performed or data and information be provided or that additional requirements be imposed in connection with Purchaser’s transfer of the Products to a new facility in order to exploit the Regulatory
Approvals. 

 Section 5.01(c) 

Commingled Documents 
 (i) 

 

							
	 Commingled Document

Type
	  	 Document Description
	  	 Document Format
	  	 Method of Delivery to

Purchaser

	Current Supplier Dossiers and Vendor Qualification for current suppliers of vials, stoppers, seals, active pharmaceutical ingredients, and excipients	  	 A Supplier Dossier is a package of
 documents
which supports the adequacy of the supplier (vendor or manufacturer) to provide a raw material or component. The dossier may include the quality agreement, quality standards, standard operating procedures, supplier questionnaires and any audit
results.
  
 Vendor Qualification includes documentation supporting the auditing process
which ensures a product and/or a service provided by the vendor consistently meets the quality requirements set forth by the firm.
	  	Paper and Electronic (some in each format)	  	All commingled supplier dossiers will be transferred to Purchaser. Information in these dossiers identifying products not included in the Transferred Assets, and the respective customer information, will be
redacted.
				
	Field Alert Reports (FAR)	  	FDA form filed when there is any known failure to meet specifications (testing requirements) of one or more distributed batches of the drug product as established in the drug product application (NDA or ANDA).	  	Paper and Electronic (some in each format)	  	All commingled Field Alert Reports will be transferred to Purchaser. Information in these reports identifying products not included in the Transferred Assets, and the respective customer information, will be
redacted.

							
	 Commingled Document

Type
	  	 Document Description
	  	 Document Format
	  	 Method of Delivery to

Purchaser

	Recall Documentation	  	The documentation filled out to designate the need to remove or correct a marketed product that the FDA considers to be in violation of the Laws it administers and against which the agency would initiate legal action, e.g.,
seizure.	  	Paper and Electronic (some in each format)	  	All Transferred Asset-specific Recalls will be transferred to Purchaser.
				
	Container Closure Integrity Testing Reports	  	A container closure system refers to the sum of packaging components that together contain and protect the drug product. The report shows that each of the components conforms to sterility requirements that when the product is placed
in the component, sterility is maintained.	  	Paper	  	All container closure integrity testing reports will be transferred to Purchaser. Information in these reports identifying products not included in the Transferred Assets, and the respective customer information, will be
redacted.
				
	FDA Minutes	  	Minutes from meetings with the FDA to discuss the state of BVL and the Transferred Assets, supply from 2011 forward.	  	Paper and Electronic (some in each format)	  	Minutes from meetings with the FDA from 2011 to the present will be transferred to Purchaser. Information in these minutes identifying products not included in the Transferred Assets, and the respective customer information, will be
redacted.
				
	Validation Reports and Raw Data	  	Validation reports and raw data from the quality function	  	Electronic (for validation reports) and Paper (for raw data)	  	All validation reports and raw data will be transferred to Purchaser. Information in these materials identifying products not included in the Transferred Assets, and the respective customer information, will be redacted.

 (ii) 
  

							
	 Commingled Document

Type
	  	 Document Description
	  	 Document Format
	  	 Method of Delivery to

Purchaser

	Investigations (including Investigations related to Field Alert Reports and Recalls)	  	 An investigation is the process and the documentation of the process of using inquiries and examinations to gather facts and information to
solve a problem or resolve an issue with root cause of the problem.
  
 The problem is an
event determined to have an impact on a regulatory submission, validated (tested and confirmed) parameter, policies or specifications (acceptance criteria).
	  	 Paper and Electronic
 (some in each
format)
	  	 Summaries of Product specific investigations for commercial Products are included in Annual Product Reviews (2009 to present) that will be
provided to Purchaser.
  
 Investigations tied to ANDA submissions will be provided to
Purchaser as part of the ANDA with redaction to remove non-Transferred Asset specific information.
  

Upon request, Seller will use commercially reasonable efforts to obtain from Hikma, or provide Purchaser with access to, such information (which will have all non-Transferred Asset information redacted).

				
	Out of Specification (OOS) and Out of Trend (OOT) Reports for Laboratory Results	  	The specification is the explicit set of requirements to be satisfied by the product, raw material or component, which makes it suitable for use. When these requirements are not met that failure is called being “out of
specification.” The documentation represents the investigation performed to understand the out of specification event.	  	 Paper and Electronic
 (some in each
format)
	  	 Summaries of product specific OOS and OOT reports for Transferred Assets are included in Annual Product Reviews (2009 to present) that will
be provided to Purchaser.
  
 Upon request, Seller will use commercially reasonable
efforts to obtain from Hikma, or provide Purchaser with access

							
	 Commingled Document

Type
	  	 Document Description
	  	 Document Format
	  	 Method of Delivery to

Purchaser

		  	An out of trend result is one that does not follow the expected values with respect to previously collected data. That data may be within specification but not within the norm for that product. The documentation represents the
investigation performed to understand the out of trend event.	  		  	to, such information (which will have all non-Transferred Asset information redacted).
				
	Change Controls	  	The commercial system process to document all changes that have the potential to impact product registration, cGMPs, product attributes (safety, identity, strength, purity and quality) and/or the state of validation of processes,
equipment, instruments, facilities and systems.	  	Paper and Electronic (some in each format)	  	 Summaries of Product specific change controls are included in Annual Reports to the FDA that will be provided to Purchaser.

 
 Upon request, Seller will use commercially reasonable efforts to obtain from Hikma, or
provide Purchaser with access to, such information (which will have all non-Transferred Asset information redacted).

				
	Corrective Actions and Preventive Actions (CA/PA)	  	 A corrective action is the immediate action and the documentation of the action taken to eliminate or mitigate the effects of an existing
nonconformance (failure to meet criteria or perform to procedure), defect or any other event which is outside the regulatory filing.
  

A preventive action is an action and the documentation of the action taken to reduce the potential of reoccurrence of the defined root cause in an
investigation or nonconformance.
	  	Paper and Electronic (some in each format)	  	 Summaries of product specific change controls resulting from CA/PA actions are included in Annual Reports to the FDA that will be provided to
Purchaser.
 Upon request, Seller will use commercially reasonable efforts to obtain from Hikma, or provide Purchaser with access to, such information (which
will have all non-Transferred Asset information redacted).

 (iii) 
  

							
	 Commingled Document

Type
	  	 Document Description
	  	 Document Format
	  	 Method of Delivery to
Purchaser

	 Laboratory Notebooks – Development (Pre Product Approval and Support Post Approval)

 
 Includes all work tied to development work for all Bedford Business Products and all
Transferred Assets/Products, pre-product approval and post-approval.
	  	Documentation from the laboratory and the primary record of laboratory testing for product development and lifecycle management. May include interpretation of the analysis or an assessment against a defined set of limits.	  	Paper for those not commingled, Electronic (and redacted) for those commingled.	  	Notebooks containing Transferred Asset information will be scanned, redacted and Purchaser will receive electronic copies of all Transferred Asset information.

 Section 8.05(b)(ii) 

Permitted Liens 
 None. 

 Section 8.05(b)(iii) 

Products 
 acyclovir sodium 

bumetanide 
 diltiazem hydrochloride 

dipyridamole 
 doxapram hydrochloride 

enalaprilat 
 famotidine 

prochlorperazine edisylate 
 propranolol hydrochloride 

terbutaline sulfate 
 valproate sodium 

  Exhibit A 

Forms of Transfer Documents 
 (See
attached) 

 BILL OF SALE AND 

ASSIGNMENT AND ASSUMPTION AGREEMENT 

This Bill of Sale and Assignment and Assumption Agreement (this “Agreement”) is made and entered into effective as of
            , 2017 by and between Athenex, Inc., a Delaware corporation (“Purchaser”) and Amphastar Pharmaceuticals, Inc., a Delaware corporation
(“Seller”). Seller and Purchaser may each be referred to herein as a “Party” and collectively as the “Parties.” 

RECITALS 
 WHEREAS,
Seller and Purchaser have entered into that certain Asset Purchase Agreement, dated as of             , 2017 (as the same may be amended, restated, supplemented or modified from time to
time, the “Asset Purchase Agreement”); and 
 WHEREAS, pursuant to the Asset Purchase Agreement.
Seller has agreed to sell the Transferred Assets and transfer the Assumed Liabilities to Purchaser, and Purchaser has agreed to purchase the Transferred Assets and assume the Assumed Liabilities from Seller. 

AGREEMENT 
 NOW,
THEREFORE, for consideration of the mutual agreements and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound,
agree as follows: 
 1. Definitions. Unless otherwise specifically provided herein, capitalized terms used in this Agreement and not
otherwise defined herein shall have the respective meanings ascribed thereto in the Asset Purchase Agreement. 
 2. Conveyance
and Acceptance. In accordance with the provisions of the Asset Purchase Agreement, Seller hereby sells, transfers, conveys, assigns and delivers to Purchaser all of Seller’s right, title and interest in and to the Transferred
Assets, and Purchaser hereby purchases and accepts the Transferred Assets, in each case, free and clear of all Liens other than Permitted Liens. 

3. Assumption of Assumed Liabilities. In accordance with the provisions of the Asset Purchase Agreement, Seller
hereby assigns to Purchaser the Assumed Liabilities and Purchaser hereby assumes and agrees to pay and discharge when due the Assumed Liabilities. 

4. Asset Purchase Agreement Controls. Notwithstanding any other provision of this Agreement to the contrary,
nothing contained herein shall in any way supersede, modify, replace, amend, change, rescind, waive, exceed, expand, enlarge or in any way affect the provisions, including warranties, covenants, agreements, conditions, representations or, in general
any of the rights and remedies, or any of the obligations of Purchaser or Seller set forth in the Asset Purchase Agreement. This Agreement is subject to and governed entirely in accordance with the terms and conditions of the Asset Purchase
Agreement. Nothing contained herein is intended to modify or supersede any of the provisions of the Asset Purchase Agreement. 

 5. Miscellaneous. 

(a) This Agreement, the negotiation, execution or performance of this Agreement and any disputes arising under or related
hereto (whether for breach of contract, tortious conduct or otherwise) shall be governed and construed in accordance with the Laws of the State of Delaware, without reference to its conflicts of laws principles that would refer the interpretation or
construction of, or resolution of any dispute under, this Agreement to the substantive Laws of another jurisdiction. 
 (b)
This Agreement may be amended, modified, superseded or canceled, and any of the terms, covenants, representations, warranties or conditions hereof may be waived only by an instrument in writing signed by each of the parties or, in the case of a
waiver, by or on behalf of the party waiving compliance. No course of dealing between the parties shall be effective to amend of waive any provision of this Agreement. 

(c) All legal and other costs and expenses incurred in connection herewith and the transactions contemplated hereby shall
(except as otherwise provided herein) be paid by the Party incurring such expenses. 
 (d) This Agreement shall be binding
upon, inure to the benefit of, and be enforceable by, the Parties and their respective successors and permitted assigns. 

(e) In the event that any provision contained in this Agreement shall for any reason be held to be illegal, invalid or
unenforceable in any jurisdiction, such provision shall be ineffective as to such jurisdiction to the extent of such invalidity, illegality or unenforceability without invalidating or affecting the remaining provisions hereof or affecting the
validity, legality or enforceability of such provision in any other jurisdiction. Upon such a determination, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties hereto as
closely as possible in a reasonably acceptable manner in order that the transactions contemplated hereby may be consummated as originally contemplated to the fullest extent possible. 

(f) This Agreement may be executed in one or more counterparts, all of which shall be considered one and the same agreement,
and shall become effective when each party hereto shall have received counterparts hereof signed by each of the other parties hereto. If any signature is delivered by facsimile transmission or by PDF, such signature shall create a valid and binding
obligations of the party executing (or on whose behalf the signature is executed) with the same force and effect as if such facsimile or PDF signature were an original thereof. 

[Signature page follows] 

  
 2 

 IN WITNESS WHEREOF, the Parties hereto have each caused this Agreement to be
duly executed as of the Closing Date. 
  

			
	SELLER:
	
	AMPHASTAR PHARMACEUTICALS, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	PURCHASER:
	
	ATHENEX, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	

 SIGNATURE PAGE 

BILL OF SALE AND ASSIGNMENT AND
ASSUMPTION AGREEMENT 

 Exhibit B 

Form of Purchaser Change in Ownership Letters 

[Purchaser’s Letterhead] 
 [Date], 2017 

Office of Generic Drugs 
  

			
	 Re:
	  	 ANDA [*]

		  	 [Product Name]

		  	 Change of Ownership Acceptance

 Dear Sir/Madame: 
 With this
letter, we wish to notify the Food and Drug Administration (“FDA”) consistent with 21 C.F.R. § 314.72(a)(1) that, effective             , 2017 the ownership of the
above-referenced Abbreviated New Drug Application (“ANDA”) was transferred from [Seller] to [Purchaser] (“[Purchaser]”). 

Additionally, [Purchaser] is hereby appointing the following U.S. Agent for this application: 

[U.S. Agent] 
 [Contact] 

[Address] 
 [Phone] 

[Purchaser Language Option #1: In accordance with 21 C.F.R. 314.72(a)(2)(iii), [Seller] has provided to [Purchaser] a complete copy of the approved ANDA,
including supplements and records that are required to be kept under 21 C.F.R. 314.81. OR Purchaser Language Option #2: In accordance with 21 C.F.R. 314.72(a)(2)(iii), [Purchaser] hereby requests [or has requested] from FDA a complete copy of
the approved ANDA.] In accordance with 21 C.F.R. §314.72(a)(2)(i), [Purchaser] commits to all agreements, promises and conditions made by the former owner, [Seller], and contained in the application. Consistent with 21 C.F.R.
§ 314.72(b), [Purchaser] commits to advising FDA about any change in the conditions in the approved application under 21 C.F.R. § 314.70. 

Enclosed in this submission is a Letter of Authorization from [Purchaser] authorizing [U.S. Agent] to act on their behalf as it relates to Agency matters
regarding this ANDA. 
 Written acknowledgement of the change in ANDA ownership would be appreciated. Please contact the undersigned if you have any
comments or questions regarding this letter. 
 This submission is being provided in electronic format. It has been scanned with [McAfee Virus Scan
Enterprise [insert version]] and found to be virus-free. [For technical issues unrelated to the content of this submission, please contact [name] at [phone number]]. [Optional] 

Sincerely, 
 [*] 

[Purchaser] 

 Exhibit C 

Form of Seller Change in Ownership Letters 

[Seller’s Letterhead] 

[Date], 2017 
 [Address of FDA Contact] 

Re: ANDA [*] 
 [Product Name] 

Transfer of ANDA Ownership 
 Dear Sir/Madame: 

With this letter, we wish to notify the Food and Drug Administration (“FDA”) consistent with 21 C.F.R. § 314.72(a)(1) that, effective
            , 2017, [Seller] has transferred all rights to the above-referenced Abbreviated New Drug Application (“ANDA”) to [Purchaser] (“[Purchaser]”). 

Written acknowledgement of the change in ANDA ownership would be appreciated. Please contact [Seller contact’s name, phone number and email address] or
[Buyer contact’s name, phone number and email address] if you have any comments or questions regarding this letter. 
 This submission is being
provided in electronic format. It has been scanned with [McAfee Virus Scan Enterprise [insert version]] and found to be virus-free. For technical issues unrelated to the content of this submission, please contact [name] at [phone number]. 

Sincerely, 
 [*] 

[Seller] 

  
 PPAB 3547796v2EX-10.23

 Exhibit 10.23 

EMPLOYMENT AGREEMENT 

Amended and Restated June 1, 2015 

THIS AGREEMENT is an amendment and restatement of the agreement entered into on March 1, 2013, and amended and restated
effective March 10, 2014, by and between Johnson Lau (the “Executive”), and Kinex Pharmaceuticals, Inc. (the “Corporation”). 

Recitals 
 A. The
Executive is the Chief Executive Officer of the Corporation and the parties intend that the Executive continue in that role. 
 B. Effective
July 26, 2015, the board of directors of the Corporation (the “Board”) approved a further amendment to this Agreement to provide for the engagement of Executive in a continuing consulting relationship in the event of Executive’s
termination of employment in order to retain Executive’s experience, expertise and knowledge so that the Corporation can achieve its business strategies and a successful leadership transition. 

NOW, THEREFORE, in consideration of the Executive’s employment and continued employment, the parties hereby agree as
follows, effective June 1, 2015, except as otherwise provided herein: 
 1. Employment. The Corporation agrees to
continue the employment of Executive, and Executive hereby accepts continued employment with the Corporation, upon the terms and conditions set forth in this Agreement for the period beginning and ending in Section 5 (the “Employment
Period”). 
 2. Position and Duties. 

(a) During the Employment Period, Executive shall serve as the Corporation’s Chairman of the Board, Chief Executive Officer or both as
determined by the Board from time to time. While Executive holds the position of Chairman of the Board, Chief Executive Officer or both, Executive shall be considered an Executive and an officer of the Corporation, obligating Executive and the
Corporation to the rights and duties inherent in an employment relationship. Executive shall be based at his primary residence (currently California) during the Employment Period and shall travel as required to perform his duties under this
Agreement. 
 (b) Executive’s duties shall include the normal duties, responsibilities and authority of Chairman of the Board, Chief
Executive Officer, or both, as specified in the by-laws of the Corporation and subject to the power of the Board to expand or limit such duties, responsibilities and authority and to override actions of
officers of the Corporation. Such duties shall specifically involve the responsibility for financing, business development, direct management of senior Executives of the Corporation, management of the Board approved budgets and capital spending
plans, management of relationships with the lenders and investors of the Corporation, and any other responsibilities assigned to the Executive by the Board that are consistent with his title and position. In this position, the Executive shall devote
his best efforts, attention and energies to the business and affairs of the Corporation. Executive shall perform his duties and responsibilities to the Corporation to the best of his abilities in a diligent, trustworthy, and businesslike manner. In
the performance of his duties hereunder, Executive shall at all times report and be subject to the lawful direction of the Board and perform his duties hereunder subject to and in accordance with the resolutions or any other determinations of the
Board, the by-laws of the Corporation, as from time to time in effect (consistent with his title and position as Chairman of the Board, Chief Executive Officer, or both) and any Executive Manual applicable to
all Executives of the Corporation. 

  
 1 

 (c) During the Employment Period, Executive shall spend 75% of his full business time in the
performance of his duties under this Agreement. Executive may also hold executive positions at other unrelated entities. 
 (d) Upon
request, Executive shall make application for, and submit to any examination as may be reasonably requested by, the Board in order to obtain key-man or other insurance on the life of Executive for the benefit
of the Corporation as the Board shall direct provided that the results of such examination shall have no bearing on his continued employment hereunder. 

(e) The Corporation will obtain and maintain “Directors and Officer” insurance coverage for the Executive in his position as
Chairman of the Board and Chief Executive Officer that is at all times in an amount and with coverage appropriate for officers and directors of the Corporation. Such insurance may offset the Corporation’s indemnification obligations to
Executive under its certificate of incorporation and bylaws, which obligations are set forth in Exhibit A hereto. The Corporation’s indemnification obligations to Executive may not be diminished by future amendments to its certificate of
incorporation or bylaws. 
 3. Base Salary, Incentives
and Benefits. 
 (a) Base Salary. During the Employment Period, Executive’s base salary
shall be at a pro-rated amount based on current assessment of his agreed time commitment, and as of the date of this Agreement, will have an annual rate of Two Hundred Thousand and NO/100 Dollars ($200,000),
payable in regular installments by, and in accordance with, the general payroll practices of the Corporation. In addition, the Corporation will provide deferred compensation in the annual amount of Three Hundred Thousand and NO/100 Dollars
($300,000) (“Deferred Compensation”) payable as described in Section 3(b). Such amounts together are referred to herein as the “Base Salary”. All compensation payable hereunder is subject to customary deductions for
withholdings, including, without limitation, federal and slate withholding taxes, social security taxes and state disability insurance. 

(b) Deferred Compensation. The Deferred Compensation described in Section 3(a) is subject to the terms of the Corporation’s Non-Qualified Deferred Compensation Plan that has been adopted by the Corporation and as it may be amended. All Deferred Compensation shall bear simple interest at the rate four (4%) per annum until paid. Any
partial payment of Deferred Compensation by the Corporation shall be applied first to the payment of such interest. Executive shall execute such agreements and documents from time to time as may be required under the terms of such Plan to implement
the agreement set forth in this Section 3(b). 

  
 2 

 (c) Stock Incentive. 

(i) For purposes of this Section 3(c), “Liquidity Event” shall mean (A) an underwritten public offering of the capital
interests of the Corporation resulting in gross proceeds to the Corporation less underwriting fees and expenses of at least $25,000,000, (B) sale of all or substantially all of the assets of the Corporation resulting in the payment of
liquidating dividends to the shareholders of the Corporation, or (C) a merger, consolidation, exchange or similar transaction resulting in the holders of more than 50% of the outstanding shares of the Corporation receiving cash or publicly
traded securities of a third party upon the surrender of their Corporation shares. 
 (ii) If a Liquidity Event is consummated by the
Corporation in Asia while Executive is Chairman of the Board of the Corporation or a Liquidity Event is consummated by the Corporation in the United States or Europe while Executive is Chief Executive Officer of the Corporation, on the date of
consummation of a Liquidity Event, and the valuation of the Corporation for purposes of the Liquidity Event is greater than US$200,000,000, the Corporation shall issue to Executive, for no further consideration, one hundred thousand (100,000) shares
of the Corporation’s Common Stock, $.001 par value, immediately prior to the consummation of the Liquidity Event. 
 (iii) Nothing
contained in this Agreement shall prevent the Board from terminating the Executive as Chief Executive Officer or Chairman of the Board or prevent Executive from resigning as Chief Executive Officer or Chairman of the Board of the Corporation at any
time. Except as provided in Section 3(c)(ii), the Corporation shall have no obligation to issue any shares to Executive under this Agreement if he does not hold the required position (Chief Executive Officer or Chairman of the Board) on the
date the Liquidity Event is consummated. 
 (iv) The number of shares to be issued to Executive under Section 3(c)(ii) above shall be
adjusted from time to time for stock splits, dividends, subdivision, combination, or reclassification so that the number of shares of Common Stock issuable under this Section 3 is equal to the number of shares of Common Stock Executive would
have been entitled to receive in connection with such split, dividend, subdivision, combination, or reclassification if the Common Stock had been issued and held by the Executive on the effective date of such split, dividend, subdivision,
combination or reclassification. 
 (d) Benefits. In addition to the Base Salary and Stock Incentive described in Sections 3(a)
and (c) above, Executive shall be entitled, during the Employment Period (and following the Employment Period to the extent provided below), to participate in all bonus, option, retirement, disability, pension, savings, health, medical, dental,
insurance and other fringe benefits or plans of the Corporation generally available to other executives and senior management of the Corporation (“Benefits”). 

(e) Note Installments. With respect to the Restricted Stock purchase described in Section 4 below, during the Employment Period
(and the period following thereafter that is described in Section 6), any installment that becomes amount due under the promissory note that is executed by Executive pursuant to Section 4 shall be paid by the Corporation to Executive as
additional compensation, subject to the conditions of this Section 3(e). The Corporation’s obligation hereunder expires upon a material breach by Executive of the restrictive covenants in Sections 6, 7 or 9, the termination of
Executive for Cause (as defined in Section 5(c)), or the resignation of Executive without Good Reason (as defined in Section 5(e)). 

  
 3 

 (f) Annual Review. Executive and the Corporation shall meet annually beginning in 2013 to
review and revise Executive’s compensation for the next calendar year including Base Salary, Deferred Compensation, stock incentives and bonuses. If Executive and the Corporation are unable to agree on Executive’s compensation for the next
calendar year on or before December 31 of the current calendar and Executive resigns as the result thereof; such resignation shall be deemed to be a termination of the Executive by the Corporation without cause or by non-renewal under Section 5(0 of this Agreement and not a voluntary resignation. 
 4.
Restricted Stock Purchase. The Executive acquired Two Hundred Thousand (200,000) shares of the Corporation’s Series A Preferred Stock, $.001 par value, (the “Restricted
Shares”) on March 10, 2014 under the terms and conditions set forth in this Agreement prior to this amendment and restatement. The purchase price for the Restricted Shares was determined as the fair market value of such shares, as
determined by the Board in good faith and in consultation with the Executive (the “Purchase Price”), which fair market value may also be expressed as a per share purchase price (the “Per Share Purchase Price”). The Purchase Price
has been paid by the delivery of a full recourse promissory note executed by Executive for the benefit of the Corporation and delivered to the Corporation. Pursuant to a conversion of the Corporation’s Series A Preferred Stock, dated
May 6, 2014, the Restricted Shares were converted into 220,000 shares of the Corporation common stock. The Corporation and Executive contemplate that any other equity-based incentive arrangements will be provided for under separate stock
incentive plans or agreements between the Corporation and the Executive. 
 (a) Vesting of Restricted Shares. Except as provided in
Section 4(b), the Restricted Shares shall vest according to the following schedule, conditioned on Employee continuing to provide services hereunder. Any Restricted Shares which have fully vested pursuant to this Section 4 shall be
referred to in this Agreement as “Vested Shares.” Any Restricted Shares which have not become Vested Shares shall be referred to in this Agreement as “Unvested Shares.” 

(i) The parties acknowledge that one-third of the Restricted Shares became vested on March 9,
2015; 
 (ii) An additional one-third of the Restricted Shares shall vest on March 9, 2016;

 (iii) An additional one-third of the Restricted Shares shall vest on March 9, 2017. 

  
 4 

 (b) Other Vesting Events. The Restricted Shares that have not become forfeited hereunder
will become vested, as described below, upon the occurrence of the following: 
 (i) The Restricted Shares shall become 100% vested upon
the occurrence of a Liquidity Event described in clause (A) of Section 3(c)(i). 
 (ii) The Restricted Shares shall become 100%
vested upon the occurrence of a Change of Control described in Section 5(g), whether or not Executive’s employment is terminated. 

(iii) Upon Death or Permanent Disability, the portion of the Restricted Shares that have become Vested Shares is the aggregate of
(A) the Vested Shares determined under Section 4(a), and (B) a fraction of the Restricted Shares that arc subject to vesting during the calendar year, the numerator determined by the number of months service performed during the year
by Executive and the denominator is twelve (12). A month of service will be credited for a partial month in which the Executive is employed for at least ten (10) days. 

(c) Restrictions on Transfer of Unvested Shares. The Unvested Shares shall not be sold, exchanged, transferred, assigned, pledged,
hypothecated or otherwise disposed of, directly or indirectly, and shall not be subject to execution, attachment or similar process. 
 (d)
Repurchase by the Corporation. 
 (i) Upon the termination of Employment Period and Executive’s provision of services as a
consultant pursuant to Section 5(f), the Corporation shall have the right, but not the obligation, to repurchase all or any portion of the Restricted Shares, including any Vested Shares and/or Unvested Shares (the “Repurchase
Right”). 
 (ii) The purchase price (the “Repurchase Price”) shall be determined as follows: 

(1) The Repurchase Price for each of the Unvested Shares pursuant to which the Repurchase Right is being exercised shall be
equal to the Per Share Purchase Price. 
 (2) The Repurchase Price for each of the Vested Shares pursuant to which the
Repurchase Right is being exercised shall be equal to the Fair Market Value (as defined in Section 4(e) below). 
 (iii) The
Corporation shall have the right to exercise the Repurchase Right for ninety (90) clays after the period described above by giving to Executive written notice of such exercise, specifying the number of Vested Shares and Unvested Shares to be
repurchased by the Corporation and the aggregate Repurchase Price thereof. In the event that the Corporation has elected to exercise the Repurchase Right as to part or all of the Restricted Shares within the period described above, Executive shall
deliver to the Corporation certificate(s) representing the Shares to be acquired by the Corporation within twenty (20) days following the date of the notice from the Corporation, or within ten (10) days following determination of Fair
Market Value, whichever is later. The Corporation shall deliver to Executive against delivery of the Shares the Repurchase Price. The Corporation may pay the Repurchase Price by offsetting any amounts due under the promissory note that is described
in this Section 4 and paying the balance due in cash to Executive. 

  
 5 

 (iv) The Repurchase Right shall terminate with respect to Vested Shares and Unvested Shares for
which it is not timely exercised under Section 4(d)(iii) above. In addition, the Repurchase Right shall terminate with respect to Vested Shares upon (A) a Change of Control, or (B) the occurrence of Liquidity Event described in
clause (A) of Section 3(c)(i). 
 (e) Fair Market Value. For purposes of the Repurchase Right described in this
Section 4, the term “Fair Market Value” shall mean the fair market value per Share of the Vested Shares as agreed to in good faith between Executive and the Corporation. The parties acknowledge that the purchase price set forth in
Section 1 above represents the Fair Market Value of the Common Stock on the date hereof. If Executive and the Corporation are unable to agree upon a fair market value per Share within twenty (20) days following the notice of the exercise
of the Repurchase Right pursuant to Section 4(f) below, the value of the Vested Shares shall be determined by an independent appraiser selected by the mutual agreement of such parties. If such parties are unable to agree upon a mutually
acceptable appraiser within twenty (20) days following the notice of exercise of the Repurchase Right pursuant to Section 4(f) below, an independent appraiser selected by the Corporation and an independent appraiser selected by Executive
shall appraise the fair market value of the Vested Shares. If the two appraisers cannot agree as to the fair market value of the Vested Shares, the fair market value shall be determined by a third appraiser selected by each of the appraisers
selected by the Corporation and Executive. The Corporation and Executive shall share equally the costs of any appraisers. 
 (f)
Representations and Warranties of the Corporation. The Corporation hereby represents and warrants to Executive as follows: 
 (i)
All corporate action on the part of the Corporation, its officers and directors necessary for the authorization, execution and delivery of this Agreement, the performance of all obligations of the Corporation hereunder and the authorization,
issuance (or reservation for issuance) and delivery of the Shares being granted hereunder has been taken or will be taken prior to the execution of this Agreement, and this Agreement constitutes a valid and legally binding obligation of the
Corporation which is enforceable in accordance with its terms. 
 (ii) The Shares which are being granted hereunder, when issued, sold and
delivered in accordance with the terms hereof for the consideration expressed herein will be duly and validly issued, fully paid and nonassessable (except as set forth herein) and, based in part upon the representations of Executive in this
Agreement, will be issued in compliance with all applicable federal and state securities laws. 

  
 6 

 (g) Representations and Warranties of Executive. Executive represents and warrants to the
Corporation as follows: 
 (i) Executive represents that the Shares are being acquired for a personal account, for investment purposes
only, and not with a view to the distribution, resale or other disposition thereof. 
 (ii) Executive acknowledges that the Corporation is
issuing the Shares without registering such Shares under the Securities Act of 1933, as amended (the “Securities Act”), or the securities laws of any state, on the basis of certain exemptions from such registration requirements.

 (iii) Executive recognizes that the Shares must be held indefinitely unless they are subsequently registered or qualified under
applicable federal or state securities laws or an exemption from such registration or qualification is available, and further recognizes that the Corporation is under no obligation to register or qualify such Shares or to comply with any exemption
from such registration or qualification. 
 (iv) Executive further agrees in no event to make any disposition of all or any part of the
Shares unless and until (i) Executive shall have notified the Corporation of the proposed disposition; (ii) Executive shall have received an opinion of counsel to the effect that such disposition will not require the registration or
qualification of the Shares under applicable securities laws; and (iii) such opinion of counsel shall have been concurred in by the Corporation’s counsel and the Corporation shall have advised Executive of such concurrence. Executive
acknowledges that any certificates representing the Restricted Shares may bear legends that are deemed appropriate by the Corporation’s counsel regarding the restrictions on disposition of the Restricted Shares. 

(v) Executive acknowledges receipt of all such information as Executive deems necessary and appropriate to enable Executive to evaluate the
financial risk inherent in acquiring the Shares and acknowledges receipt of satisfactory and complete information covering the business and financial condition of the Corporation, including the opportunity to obtain information regarding the
Corporation’s financial status, in response to all inquiries in respect thereof. Executive acknowledges and represents that (A) Executive has a preexisting personal or business relationship with the Corporation and with certain of the
Corporation’s officers and directors, and (8) Executive has the business and financial experience necessary to evaluate this investment. 

(h) Section 83(b) Election. Executive may at his option make and submit a written election effective under
Section 83(b) of the Internal Revenue Code with the Internal Revenue Service within thirty (30) days of the date of this Agreement to be taxed on the fair market value of the Restricted Shares on the date of this Agreement over the
Purchase Price. 
 (i) Tax Withholdings. In the event that the Corporation is obligated to withhold from wages earned by Executive
with respect to the Restricted Shares in order to satisfy withholding tax obligations under federal, state or local law, which may occur due to the terms of repayment of the promissory note described in this Section 4, if the Executive does not
remit sufficient funds to satisfy such withholding obligations or make other satisfactory arrangement therefor, the Corporation may satisfy such withholding obligations by repurchasing Restricted Shares from Executive under the terms of
Section 4(d) sufficient to cover the minimum withholding obligation. 

  
 7 

 (j) California Corporate Securities Law. The offer and sale of the Shares which arc the
subject of this Agreement have not been qualified with the Commissioner of Corporations of the State of California and the issuance of such securities or the payment or receipt of any part of the consideration therefor prior to such qualification is
unlawful, unless the sale of securities is exempt from the qualification by Section 25100, 25102, or 25105 of the California Corporations Code. The rights of all parties to this Agreement are expressly conditioned upon such qualification being
obtained, unless the offer and sale of the Shares is so exempt. 
 5. Term and
Termination. 
 (a) General Term. The Employment Period shall commence on March 1, 2013 and end on
February 28, 2016, subject to renewal as provided in Paragraph 5(b) below, and subject to earlier termination (i) by reason of Employee’s death or Permanent Disability, (ii) by an appropriate resolution of the Board with Cause or
(iii) upon Employee’s voluntary resignation. 
 (b) Renewal. On March 1, 2016 and each anniversary thereof, the
Employment Period shall automatically be extended for a period of one additional year beyond then-current Employment Period, unless on or before such date either party delivers a written notice at least ninety (90) days in advance of such date
to the other party stating that they do not desire any such renewal. 
 (c) Termination for Cause. If the employment relationship is
terminated by the Corporation for Cause, the Executive shall be entitled to his Base Salary, Bonuses, and Benefits through the date of termination, but shall not be entitled to any further Base Salary or Benefits (other than Benefits that are
required to be provided by law, if any) for that year or any future year, or to any severance compensation of any kind, nature or amount. For purposes of this Agreement, “Cause” means ally of the following: (i) Executive’s
commission of a felony or other crime involving moral turpitude or the commission of any other act or omission involving dishonesty, disloyalty (i.e., a breach of fiduciary duty of loyalty), or fraud with respect to the Corporation; (ii) breach
of fiduciary duties by Executive; (iii) gross negligence or willful misconduct with respect to the Corporation; (iv) substantial or repeated failure to perform material employment duties assigned by the Board which are consistent with the
Executive’s title and position, and, if curable, which failure is not cured within 15 days after written notice is delivered to the Executive; or (v) material breach of Executive’s obligations under Sections 6, 7 or 9 of
this Agreement, which breach, if curable, is not cured within 30 days after written notice. Any notice referred to above must be from the Board and specifically describe the purported grounds for Cause and identify that it is intended to
constitute notice for purposes of this definition of Cause. A Change of Control shall not, in the absence of one of the items enumerated above, constitute “Cause.” 

  
 8 

 (d) Death or Permanent Disability. If Executive’s employment is terminated as a
result of his death or Permanent Disability, the Corporation shall pay to Executive all previously earned and accrued but unpaid Base Salary, Bonuses, and Benefits up to the date of death. Executive shall not be entitled to any further Base Salary
or Benefits (other than Benefits that arc required to be provided by law or under the terms of the applicable benefit plans, if any) for that year or any future year, or to any severance compensation of any kind, nature or amount. For purposes of
this Agreement, “Permanent Disability” shall mean the Executive’s inability to substantially perform his duties under this Agreement for a continuous period of three (3) months or for an aggregate of six (6) months during
any twelve (12) month period as the result of illness, disease, injury, or infirmity, or the date of any earlier determination made by a physician selected by the Shareholders or their legal representatives. 

(e) Resignation by Executive. Except as provided in Section 3(e), if the Executive’s employment is terminated voluntarily by
the Executive without Good Reason, Executive shall be entitled to his Base Salary, Bonuses, and Benefits through the date of termination, but shall not be entitled to any further Base Salary or Benefits (other than Benefits that are required to be
provided by law and under the terms of the applicable benefit plans, if any) for that year or any future year, or to any severance compensation of any kind, nature or amount. Any resignation by Executive shall be deemed to be a resignation with
respect to all positions under this Agreement. For purposes of this Agreement, termination for Good Reason means a resignation within two years of the occurrence of any of the following events: 

(i) A material and selective reduction in Base Salary, but not including a reduction in compensation that is applied generally to executive
officers of the Corporation and necessitated by financial conditions. 
 (ii) A material reduction of Executive’s authority, duties or
responsibilities. 
 (iii) A material breach of this Agreement by the Corporation. 

(f) Termination Without Cause, Non-Renewal, or Termination For Good Reason.
Executive will be entitled to the payments and benefits described in this Section 5(1) in the event that Executive’s employment is terminated: (i) by the Corporation without Cause, (ii) because the Corporation elects to not renew
this Agreement at the end of any Employment Period, other than pursuant to Sections 5(c), 5(d), or 5(g), or (iii) Executive resigns for Good Reason. In any such event, Executive shall be entitled to: (A) all Base Salary, Bonuses, and
Benefits through the date of termination, (B) Base Salary in effect as of the date of termination for a period thirty-six (36) months following the date of such termination, payable as described in
Section 5(i) below, (C) a cash payment that is equivalent to the value of the Employer’s contribution to any Benefits subscribed to by Executive at the time of termination for a thirty-six
(36) month period, and (D) continued vesting credit for purposes of the Restricted Stock award described in Section 4 for a period of up to two years, or the lesser period required to provide full vesting of such award,
provided that Executive provides consulting services described in Section 5(k) during such period. Executive shall not be entitled to any other severance compensation of any kind, nature or amount. 

  
 9 

 (g) Change of Control. In the event of a Change of Control, wherein Executive is
terminated by the Corporation without cause or by non-renewal of this Agreement other than pursuant to Sections 5(c) or 5(d) above, Executive shall be entitled to (1) all Base Salary, Bonuses, and
Benefits through the date of termination, and (ii) Base Salary, Bonuses, and the Corporation’s contribution to any Benefits subscribed to by Executive as of the date of termination for a period of
thirty-six (36) months following the date of such termination, payable as described in Section 5(i) below, and Executive shall not be entitled to any other severance compensation of any kind, nature
or amount. For purposes of this Agreement, “Change of Control” shall mean the satisfaction of any one or more of the following conditions: (i) any person or entity (hereinafter in this definition, “Person”), other than the
Corporation or an affiliate, becomes the beneficial owner, directly or indirectly, of securities of the Corporation representing more than 50% of the combined voting power of the Corporation’s then outstanding securities; (ii) the
Corporation’s shareholders approve a merger, consolidation or other business combination (a “Business Combination”) other than a Business Combination in which holders of common stock of the Corporation immediately prior to the
Business Combination have substantially the same proportionate ownership of the equity of the surviving corporation or other business entity immediately after the Business Combination as immediately before; (iii) the Corporation’s
shareholders approve either an agreement for the sale or disposition of all or substantially nil of the Corporation’s assets to any entity that is not an affiliate, or a plan of complete liquidation of the Corporation; or (iv) the persons
who were Directors immediately before a tender offer by any Person other than the Corporation or an affiliate, or before a merger, consolidation or contested election, or before any combination of such transactions, cease to constitute a majority of
the members of the Board as a result of such transaction or transactions, or the Corporation engages in a business transaction or agreement with a third-party that obtains and exercises the right to replace the majority of the members of the Board,
including the Corporation’s Chairman of the Board. 
 (h) Breach of Covenants. Executive agrees that Executive shall be entitled
to the payments provided for in Sections 5(1) or 5(g) if and only if Executive has not breached as of the date of termination of the Employment Period the provisions of Sections 6, 7 and 9 hereof and does not breach such sections at any
time during the period for which such payments are to be made; provided, that the Corporation’s obligation to make such payments will terminate immediately upon the occurrence of any such breach during such severance period. 

(i) Timing of Payments. Any payments pursuant to Sections 5(0 or 5(g) shall be made in installments on the payment dates on which
Executive’s Base Salary would have otherwise been paid if the employment relationship had continued in accordance with the Corporation’s standard payroll policies, and as of the date of the final such payment the Corporation shall not have
any further obligation to Executive pursuant to this Section 5. However, if such termination of employment is within one year following a Change in Control, payments shall be made in a single sum within ten (10) days of such termination.
Notwithstanding the foregoing, if Executive is a “specified employee” described in Treas. Reg. § 1.409A-1(i), such payments will commence (or be paid) on the day that follows six
(6) months Executive’s termination of employment or, if sooner, upon death; provided that all installment payments that would have otherwise been paid during such six-month period if Executive were
not a “specified employee” shall be paid in a single sum at that time and regular installment payments will continue thereafter. 

  
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 (j) Limits on Severance. Executive hereby agrees that no severance compensation of any
kind, nature or amount shall be payable to Executive, except as expressly set forth in this Section 5, and Executive hereby irrevocably waives any claim for any other severance compensation. Executive shall have no duty of mitigation and the
Base Salary severance payable hereunder will not be reduced by or for any other compensation, earnings, or employment obtained by Executive. With respect to Benefits severance, Benefits severance shall terminate upon the subsequent employment of
Executive if benefits comparable to the Benefits are available to Executive from such subsequent the Corporation. 
 (k) Consulting
Services. Notwithstanding the foregoing, in the event that the employment of Executive terminates for reasons other than for Cause, as defined in Section 5(c), or death on and after July 26, 2015, the Executive may thereupon elect to
continue to provide substantial services to the Corporation as a consultant for a continuing period of up to three years. The consulting services provided by Executive will include assisting in the implementation of key initiatives of the
Corporation’s business plan that has been adopted by the Board, identifying and recruiting a successor to the role that is served by the Executive under this Agreement, the transition of duties to such successor, advising the Board and
management regarding finances and the operations of the Corporation, and other duties reasonably assigned by the Board. During the period of the consulting relationship, the Executive shall: (i) be paid reasonable compensation for services
rendered to the Corporation or its affiliates, (ii) receive continuation of health insurance or payment of premiums, (iii) be deemed to be employed for the purposes of satisfying the vesting and other conditions under the Restricted Stock
purchase and related promissory note described in this Agreement and in any other restricted stock, stock option or equity-based incentive award, and in any supplemental retirement or deferred compensation arrangement, and (iv) continue to be
subject to other applicable covenants contained in the Agreement, including the restrictive covenants described in Sections 6, 7, 8 and 9. The parties may enter into a separate consulting agreement that includes the terms of this
Section 5(k). 
 6. Non-Competition. 

(a) Field of Interest. Executive recognizes and acknowledges the competitive and proprietary nature of the Corporation’s business
operations. Executive acknowledges and agrees that a business will be deemed competitive with the Corporation if it provides products or services related to the current or proposed products or services, or information now or hereafter provided or
offered by the Corporation or under development by the Corporation that are in the Corporation’s “Field of Interest.” For purpose of clarity, the Corporation’s Field of Interest is the discovery, development, commercialization
and marketing of therapeutics (i) based on kinase inhibitors discovered through Mimetica and OPAL, (ii) pre-tubulin polymerization inhibitors, small molecules against OraA1, or
(iv) P-glycoprotein inhibitors based on HM30181A for enhanced oral absorption. 
 (b)
Further Acknowledgements. Executive further acknowledges and agrees that during the course of performing services for the Corporation, the Corporation has or will furnish, disclose or make available to Executive confidential and proprietary
information related to the Corporation’s business and that Executive has had and will have access to, and develop relationships with, the customers, vendors, partners and employees of the Corporation. Executive also acknowledges that such
confidential and proprietary information and relationships have been developed and will be developed by the Corporation through the expenditure by the Corporation of substantial time, effort and money and that all such confidential information and
relationships could be used by Executive to compete with the Corporation. 

  
 11 

 (c) Restricted Activities. The restrictive covenants provided herein are made in
consideration of the Executive’s compensation for services rendered or to be rendered to the Corporation and in view of the position held by Executive, the relationships that have been and will be developed and maintained by Executive on behalf
of the Corporation, and the confidential nature and proprietary value of the information which the Corporation may share with Executive, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged.
During the Employment Period and for a period of thirty-six (36) months following the expiration or termination of the Employment Period, and including any continuing consulting period described in
Section 5(k) (the “Restricted Term”), whether such termination is voluntary or involuntary, Executive shall not, without the prior written consent of the Corporation: 

(i) directly or indirectly, either as principal, agent, stockholder, employee, consultant, representative or in any other capacity, own,
manage, operate or control, or be concerned, connected or employed by, or otherwise act in any manner with, engage in or have a financial interest in any business which is engaged in the Field of Interest anywhere in the world, except that nothing
contained herein shall preclude Executive from purchasing or owning stock in any such business if such stock is publicly traded, and provided that Executive’s holdings do not exceed five percent (5%) of the issued and outstanding capital stock
of such business; or 
 (ii) either individually or on behalf of or through any third party, solicit, divert, hire or otherwise appropriate
or attempt to solicit, divert, hire or otherwise appropriate, for the purpose of competing in the Field of Interest anywhere in the Restricted Territory with the Corporation or with any present or future parent, subsidiary or other affiliate of the
Corporation, any employee or agent of the Corporation, any joint venture or strategic partners of the Corporation, or any customers, vendors or prospective customers or vendors of the Corporation. 

(d) Reasonableness of Restrictions. Executive further recognizes and acknowledges that (i) the types of employment which are
prohibited by this paragraph are narrow and reasonable in relation to the skills which represent Executive’s principal salable asset both to the Corporation and to Executive’s other prospective employers or customers, and (ii) the
specified but broad geographical scope of the provisions of this paragraph is reasonable, legitimate and fair to Executive in light of the Corporation’s need to perform its research and to develop and market its services and to develop and sell
its products in the global markets in order to have a sufficient customer base to make the Corporation’s business profitable and in light of the limited restrictions on the type of employment prohibited herein compared to the types of
employment for which Executive is qualified to earn his livelihood. 

  
 12 

 (e) Blue Pencil. If any part of this section should be determined by a court of competent
jurisdiction to be unreasonable in duration, geographic area, or scope, then this section is intended to and shall extend only for such period of time, in such area and with respect to such activity as is determined to be reasonable. 

7. Disclosure to Outsiders. Executive shall at all times, both during the Employment Period and
after termination of Executive’s employment, whether by the Corporation or by the Executive, maintain in confidence and not utilize the Proprietary Information or the Intellectual Property of the Corporation, or technology, business or
proprietary information of others under confidential evaluation or use by the Corporation, including information with respect to the Corporation’s Field of Interest, (collectively, “Confidential Information”) except in performing
services for the Corporation. Maintaining Confidential Information in confidence shall include refraining from disclosing Confidential Information to any third party (except when duly and specifically authorized in writing to do so for purpose of
furthering the business of the Corporation), and refraining from using Confidential Information for the account of Executive or for any other person or business entity. Executive will not file patents based on the Corporation’s Confidential
Information, nor seek to make improvements thereon, without written approval. 
 For purposes of this Agreement, the following definitions
shall apply: 
 “Intellectual Property” means all Inventions, writing, trade name, trademark,
service mark or any other material registered or otherwise protected or protectable under state, federal, or foreign patent, trademark, copyright, or similar laws. 

“Inventions” includes ideas, discoveries, inventions, developments and improvements, whether or not reduced to
practice and whether or not patentable or otherwise protected or protectable under state, federal, or foreign patent, trade mark, copyright or similar laws. 

“Proprietary Information” includes any scientific, technical, trade or business secrets of the
Corporation and any scientific, technical, trade or business materials that the Corporation treats, or is obligated to treat, as confidential or proprietary, including, but not limited to, Inventions belonging to the Corporation and confidential
information obtained by or given to the Corporation about or belonging to its suppliers, licensors, licensees, partners, affiliates, customers, potential customers or others. 

8. Disclosure to the Corporation. The Executive shall,
upon request of the Corporation, promptly communicate and disclose to the Corporation all information, observations, and data obtained by the Executive in the course of the Executive’s employment. All written materials, records mid documents
made by the Executive or coming into the Executive’s possession during his or her employment concerning the Corporation’s business (collectively, “Business Information”), shall be the sole and absolute property of the
Corporation, and upon termination of employment, or upon request of the Corporation during the Employment Period, the Executive shall promptly deliver the same to the Corporation. 

  
 13 

 9. Inventions. If during the Employment Period, Executive produces,
develops, creates, invents, conceives or reduces to practice, Inventions and Intellectual Property in the Corporation’s Field of Interest, Executive shall maintain and furnish to the Corporation complete and current records of all such
Inventions and Intellectual Property. Executive agrees that all such Inventions and Intellectual Property are and shall be the exclusive property of the Corporation, and that the Corporation may use or pursue them without restriction or additional
compensation to the Executive. Executive: (i) hereby assigns, sets over and transfers to the Corporation all of his right, title and interest in and to such Inventions and Intellectual Property; (ii) to the extent consistent with the
Copyright Act of 1976 (the “Copyright Act”), each such Invention or Intellectual Property shall be a “work made for hire” as that term is defined in Section 101 of the Copyright Act, and shall be the sole property of the
Corporation and the Corporation shall be the sole author thereof within the meaning of the Copyright Act, and if any such Invention, Intellectual Property or any portion thereof is not deemed to be a “work made for hire,” this Agreement
shall operate as an irrevocable assignment of the copyright to the Invention or Intellectual Property throughout the world, and (iii) agrees that Executive and his agents shall, during and after the period Executive is retained by the
Corporation, cooperate fully in obtaining patent, trademark, service mark, copyright, mask work or other proprietary protection for such Inventions and Intellectual Property, which action may be initiated in the Corporation’s sole and absolute
discretion, all in the name of the Corporation at its own expense, and, without limitation, shall execute all requested applications, assignments and other documents in furtherance of obtaining such protection or registration and confirming full
ownership by the Corporation of such Inventions and Intellectual Property. Executive hereby designates the Corporation as its agent, and grants to the Corporation a power of attorney with full substitution, which power of attorney shall be deemed
coupled with an interest, for the purposes of effecting the foregoing assignments from the Executive to the Corporation. Executive shall, upon leaving the Corporation, provide to the Corporation in writing a hill, signed statement of all Inventions
and Intellectual Property in which Executive participated prior to termination of Executive’s employment. 
 10.
Breach. The Executive expressly agrees that any breach of the provisions of this Agreement by him or her will result in irreparable damage to the Corporation, and it is agreed that the Corporation may prevent any such breach by
injunctive proceedings or may specifically compel performance by the Executive of his or her obligations hereunder. Executive also expressly agrees that if he violates any term of this Agreement, the Corporation, in addition to any other remedies it
may have at law or in equity, may require an accounting and repayment of all profits, compensation, remuneration or other benefits realized, directly or indirectly, as a result of such violations (A) by the Executive, or (B) by any
business engaged in the Corporation’s Field of Interest controlled, directly or indirectly, by the Executive. 
 11.
Applicable Law. This Agreement shall be governed by and construed in accordance with the laws of the state of New York, without regard to its choice of laws principles. Executive consents to the jurisdiction and
venue of the courts of the State of New York and any federal court situated in New York. 
 12. Severability. If any
court of competent jurisdiction determines that any provision contained in this Agreement, or any part thereof, is unenforceable for any reason, the Executive agrees that such court shall have the power to reduce the duration or scope of such
provision, or otherwise modify such provision, as the case may be, and, in its reduced form, such provision shall then be enforceable. If, notwithstanding the immediately preceding sentence, any court of competent jurisdiction determines that any
provision contained in this Agreement, or any part thereof, is unenforceable and cannot for any reason be reduced and enforced as described above, the Executive agrees that such determination shall not affect, impair or invalidate the remainder of
this Agreement. 

  
 14 

 13. Successors. This Agreement shall inure to the benefit of and be binding
upon the Corporation, its successors and assigns, including without limitation any corporation which may acquire all or substantially all of the Corporation’s assets or business or into which the Corporation may be consolidated or merged, and
shall likewise inure to the benefit of and be binding upon Executive, his heirs, executors, administrators and legal representatives. The Corporation may assign his right to payment or compensation, but may not assign any duties or responsibilities
or obligations assumed as a result of his employment with the Corporation. 
 14.
Non-Waiver. The Corporation’s failure to exercise any of its rights in the event the Executive breaches any of the separate and distinct promises in this Agreement, or the Corporation’s
failure to exercise any of its rights under similar contracts with other Executives, shall not be construed as a waiver of any breach or prevent the Corporation from later enforcing strict compliance with any and all promises in this Agreement. 

15. Modification. This Agreement contains the parties’ complete understanding, and there are no other agreements,
oral or written, pertaining to the subject matter of this Agreement. This Agreement supersedes any previous agreements that may exist between the parties, including any agreement that created a term of employment for the Executive. Any amendments or
modifications to this Agreement must be in writing and signed by the parties 
 16. Waiver of
Jury Trial. The Executive hereby irrevocably waives any right to trial by jury that he may have in the event that litigation is commenced between the parties at any time in the future. 

17. Opportunity to Review. The Executive hereby represents and warrants that he
(A) has had an opportunity to review this Agreement and ask the Corporation questions about the Agreement, and (B) understands the meaning and effect of each Section of this Agreement. 

18. Entire Agreement. This Agreement supersedes the Prior Agreement and any other prior agreements,
representations or promises of any kind, whether written, oral, express or implied, between the parties hereto with respect to the subject matters herein. This Agreement constitutes the full, complete and exclusive agreement between the Executive
and the Corporation with respect to the subject matters herein; provided, however, that the Corporation has entered into and may from time to time enter into separate compensatory arrangements with Executive for the
provision of fringe benefits and other benefits as described in Section 3(d) and 3(e), deferred compensation, stock-based incentive compensation and other incentive compensation. 

[Execution Page Follows] 

  
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 EXECUTION PAGE 

IN WITNESS WHEREOF, the parties have executed this Agreement which may be in multiple counterparts, each of which shall
be deemed an original, effective as of the date specified on page I. 
  

			
	  

	Johnson Lau
	
	KINEX PHARMACEUTICALS, INC.
		
	By:	 	  

		 	Jinn Wu
		 	Chair, Compensation Committee

  
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 EXHIBIT A 

Excerpts From Bylaws and Certificate of Incorporation of 

Kinex Pharmaceuticals, Inc. 

Bylaws 
 ARTICLE VII 

INDEMNIFICATION OF DIRECTORS AND OFFICERS 

7.1. The Corporation shall indemnify any person who was or is a party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the Corporation) by reason of the fact that he is or was a director, officer, employee or agent of the
Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorney’s fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred by him in connection with such action, suit or proceeding if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests
of the Corporation, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his conduct was unlawful. The termination of any action, suit or proceeding by judgment, order, settlement, conviction, or upon a plea of
nolo contendere or its equivalent, shall not, of itself, create a presumption that the person did not act in good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect
to any criminal action or proceeding, had reasonable cause to believe that his conduct was unlawful. 
 7.2. The Corporation shall indemnify
any person who was or is a party, or is threatened to be made a party to any threatened, pending or completed action or suit by or in the right of the Corporation to procure a judgment in its favor by reason of the fact that he is or was a director,
officer, employee or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another Corporation, partnership, joint venture, trust or other enterprise against expenses (including
attorneys’ fees) actually and reasonably incurred by him in connection with the defense or settlement of such action or suit if he acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the
Corporation and except that no indemnification shall be made in respect of any claim, issue or matter as to which such person shall have been adjudged to be liable to the Corporation unless and only to the extent that the Court of Chancery or the
court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, such person is fairly and reasonably entitled to indemnity for such
expenses which the Court of Chancery or such other court shall deem proper. 
 7.3. To the extent that a director, officer, employee or
agent of the Corporation has been successful on the merits or otherwise in defense of any action, suit or proceeding referred to in Sections 1 or 2 of this Article, or in defense of any claim, issue or matter therein, he shall be indemnified
against expenses (including attorneys’ fees) actually and reasonably incurred by him or her in connection therewith. 

  
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 7.4. Any indemnification under sections 1 or 2 of this Article (unless ordered by a court) shall
be made by the Corporation only as authorized in the specific case upon a determination that indemnification of the director, officer, employee or agent is proper in the circumstances because he has met the applicable standard of conduct set forth
in such section. Such determination shall be made: 
 (a) By the Board of Directors by a majority vote of a quorum consisting of directors
who were not parties to such action, suit or proceeding, or 
 (b) If such a quorum is not obtainable, or, even if obtainable a quorum of
disinterested directors so directs, by independent legal counsel in a written opinion, or 
 (c) By the stockholders. 

7.5. Expenses (including attorneys’ fees) incurred by an officer or director in defending any civil, criminal, administrative or
investigative action, suit or proceeding may be paid by the Corporation in advance of the final disposition of such action, suit or proceeding upon receipt of an undertaking by or on behalf of such director or officer to repay such amount if it
shall ultimately be determined that he is not entitled to be indemnified by the Corporation as authorized in this Section. Such expenses (including attorneys’ fees) incurred by other employees and agents may be so paid upon such terms and
conditions, if any, as the Board of Directors deems appropriate. 
 7.6. The indemnification and advancement of expenses provided by, or
granted pursuant to the other sections of this Article shall not be deemed exclusive of any other rights to which those seeking indemnification or advancement of expenses may be entitled under any bylaw, agreement, vote of stockholders or
disinterested directors or otherwise, both as to action in his official capacity and as to action in another capacity while holding such office. 

7.7. The Corporation shall have power to purchase and maintain insurance on behalf of any person who is or was a director, officer, employee
or agent of the Corporation, or is or was serving at the request of the Corporation as a director, officer, employee or agent of another Corporation, partnership, joint venture, trust or other enterprise against any liability asserted against him
and incurred by him in any such capacity, or arising out of his status as such, whether or not the Corporation would have the power to indemnify him against such liability under the provisions of this Article. 

7.8. For purposes of this Article, references to “the Corporation” shall include, in addition to the resulting Corporation, any
constituent Corporation (including any constituent of a constituent) absorbed in a consolidation or merger which, if its separate existence had continued, would have had power and authority to indemnify its directors, officers, and employees or
agents, so that any person who is or was a director, officer employee or agent of such constituent Corporation, or is or was serving at the request of such constituent Corporation as a director, officer, employee or agent of another Corporation,
partnership, joint venture, trust or other enterprise, shall stand in the same position under this Article with respect to the resulting or surviving Corporation as he would have with respect to such constituent Corporation of its separate existence
had continued. 

  
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 7.9. For purposes of this Article, references to “other enterprises” shall include
employee benefit plans; references to “fines” shall include any excise taxes assessed on a person with respect to any employee benefit plan; and references to “serving at the request of the Corporation” shall include any service
as a director, officer, employee or agent of the Corporation which imposes duties on, or involves services by, such director, officer, employee, or agent with respect to an employee benefit plan, its participants or beneficiaries; and a person who
acted in good faith and in a manner he reasonably believed to be in the interest of the participants and beneficiaries of an employee benefit plan shall be deemed to have acted in a manner “not opposed to the best interests of the
Corporation” as referred to in this Article. 
 7.10. The indemnification and advancement of expenses provided by, or granted pursuant
to, this Article shall, unless otherwise provided when authorized or ratified, continue as to a person who has ceased to be a director, officer, employee or agent and shall inure to the benefit of the heirs, executors and administrators of such a
person. 
 7.11. No director or officer of the Corporation shall be personally liable to the Corporation or to any stockholder of the
Corporation for monetary damages for breach of fiduciary duty as a director or officer, provided that this provision shall not limit the liability of a director or officer (i) for any breach of the director’s or the officer’s duty of
loyalty to the Corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the General Corporation Law of Delaware, or
(iv) for any transaction from which the director or officer derived an improper personal benefit. 

  
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 Certificate of Incorporation 

Articles Nine and Ten 

Ninth: The Corporation shall to the fullest extent permitted by Section 145 of the GCL, as the same may be amended and
supplemented, indemnify any and all directors and officers when it shall have the power to indemnify under said Section from and against any and all of the expenses, liabilities or other matters referred to in or covered by said Section, and the
indemnification provided for herein shall not be deemed exclusive of any other rights to which any person may be entitled under any by-law, resolution of stockholder, resolution of directors, agreement or
otherwise, as permitted by said Section 145, as to actions of such person in any capacity in which he or she served at the request of the Corporation. 

Tenth: Anything to the contrary in this Certificate of Incorporation notwithstanding, no director shall be liable personally to the
Corporation or its stockholders for monetary damages for breach of fiduciary duty as a director, provided however, that nothing in this paragraph shall eliminate or limit the liability of a director (i) for any breach of such director’s
duty of loyalty to the Corporation or its stockholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law, (iii) under Section 174 of the GCL, or (iv) for any
transaction from which such director derived an improper personal benefit. The modification or repeal of this Article Tenth shall not affect the restriction hereunder of a director’s personal liability for any act or omission occurring prior to
such modification or repeal. 

  
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