Document:

EX-10.10

 Exhibit 10.10 
  

 
 VIA HAND DELIVERY 

March 27, 2013 (as amended April 3, 2013) 
 Martin D.
Williams 
 10 Linnaean Street 
 Cambridge, MA 02138 

Dear Martin: 
 In connection with the termination
of your employment with Tokai Pharmaceuticals, Inc. (the “Company”) on March 27, 2013, and pursuant to the terms of your September 7, 2011 Offer Letter with the Company, you are eligible to receive the severance benefits
described in paragraph 2 below if you sign and return this letter agreement to me by April 4, 2013. By signing and returning this letter agreement, you will be entering into a binding agreement with the Company and will be agreeing to the terms
and conditions set forth in the numbered paragraphs below, including the release of claims set forth in paragraph 3. Therefore, you are advised to consult with an attorney before signing this letter agreement and you have been given at least seven
(7) days to do so. 
 If you choose not to sign and return this letter agreement by April 4, 2013, you shall not receive any
severance benefits from the Company. You will, however, receive payment for your final wages and any unused vacation time accrued through the Termination Date (as defined below). You may also, if eligible, elect to continue receiving group medical
insurance pursuant to the “COBRA” law. Please consult the COBRA materials to be provided by the Company under separate cover for details regarding these benefits. 

The following numbered paragraphs set forth the terms and conditions that will apply if you timely sign and return this letter agreement. 

 

	 	•	 	Termination Date and Resignations—Your effective date of termination from the Company will be March 27, 2013 (the “Termination Date”). You agree to resign, as of the Termination Date,
from your positions as an officer and director of the Company and of Diotima, Inc. (“Diotima”), an affiliate of the Company, and to sign and return to the Company and Diotima all letters and documents that the Company and/or Diotima may
reasonably require in order to secure your resignation. As of the Termination Date, all salary payments from the Company will cease and any benefits you had as of the Termination Date under Company-provided benefit plans, programs, or practices will
terminate, except as required by federal or state law. 

  

	 	•	 	 Description of Severance Benefits- If you timely sign and return this letter agreement and abide by all of its conditions, the Company
will, during the “Severance Period” (as defined below), continue to pay to you as severance pay your base salary rate as of your Termination Date. As used herein, the “Severance Period” shall commence on the Company’s first
payroll date following the eighth (8th) day after you execute this letter agreement, and shall continue for up to twelve (12) months; provided, however, that in the event you commence
employment with or begin providing services to another person, employer, or entity for, on average, at least twenty (20) hours per week, at a level 

	 	 
of remuneration commensurate with that last paid by the Company (or an hourly equivalent rate), the Company shall have no further severance pay obligation and the Severance Period shall
immediately cease on the date on which you commence any such employment or begin providing any such services. You are required to immediately provide the Company with written notice upon your commencement of employment with or provision of services
to another person, employer, or entity. Any severance pay during the Severance Period will be paid in installments in accordance with the Company’s normal payroll practices, but in no event shall payment begin earlier than the date on which you
execute this letter agreement. 

  

	 	•	 	 Release—In consideration of the payment of the severance benefits, which you acknowledge you would not otherwise be entitled to
receive, you hereby fully, forever, irrevocably and unconditionally release, remise and discharge the Company, Diotima, their respective affiliates, subsidiaries, parent companies, predecessors, and successors, and all of their respective past and
present officers, directors, stockholders, partners, members, employees, agents, representatives, plan administrators, attorneys, insurers and fiduciaries (each in their individual and corporate capacities) (collectively, the “Released
Parties”) from any and all claims, charges, complaints, demands, actions, causes of action, suits, rights, debts, sums of money, costs, accounts, reckonings, covenants, contracts, agreements, promises, doings, omissions, damages, executions,
obligations, liabilities, and expenses (including attorneys’ fees and costs), of every kind and nature that you ever had or now have against any or all of the Released Parties, including, but not limited to, any and all claims arising out of or
relating to your employment with and/or separation from the Company, including, but not limited to, all claims under Title VII of the Civil Rights Act of 1964, 42 U.S.C. § 2000e et seq., the Americans With Disabilities Act of
1990, 42 U.S.C. § 12101 et seq., the Genetic Information Nondiscrimination Act of 2008, 42 U.S.C. § 2000ff et seq., the Family and Medical Leave Act, 29 U.S.C. § 2601 et seq., the Worker
Adjustment and Retraining Notification Act (“WARN”), 29 U.S.C. § 2101 et seq., the Rehabilitation Act of 1973, 29 U.S.C. § 701 et seq., Executive Order 11246, Executive Order 11141, the Fair Credit
Reporting Act, 15 U.S.C., § 1681 et seq., and the Employee Retirement Income Security Act of 1974 (“ERISA”), 29 U.S.C. § 1001 et seq., all as amended; all claims arising out of the Massachusetts Fair
Employment Practices Act., Mass. Gen. Laws ch. 151B, § 1 et seq., the Massachusetts Wage Act, Mass. Gen, Laws ch. 149, § 148 et seq. (Massachusetts law regarding payment of wages and overtime), the Massachusetts
Civil Rights Act, Mass. Gen. Laws ch. 12, §§ 11H and 111, the Massachusetts Equal Rights Act, Mass. Gen. Laws. ch. 93, § 102 and Mass. Gen. Laws ch. 214, § 1C, the Massachusetts Labor and Industries Act, Mass. Gen. Laws ch. 149,
§ 1 et seq., Mass. Gen. Laws ch. 214, § 1B (Massachusetts right of privacy law), the Massachusetts Maternity Leave Act, Mass. Gen. Laws ch. 149, § 105D, and the Massachusetts Small Necessities Leave Act, Mass. Gen. Laws
ch. 149, § 52D, all as amended; all common law claims including, but not limited to, actions in defamation, intentional infliction of emotional distress, misrepresentation, fraud, wrongful discharge, and breach of contract (including, without
limitation, all claims arising out of or related to your September 7, 2011 Offer Letter); all claims to equity in the Company and its affiliates other than your vested equity interest in the Company as of the Termination Date; all state and
federal whistleblower claims to the maximum extent permitted by law; and any claim or damage arising out of your employment with and/or separation from the Company (including a claim for retaliation) under any common law theory or any federal, state
or local statute or ordinance not expressly referenced above; provided, however, that nothing in this letter agreement prevents you from filing a charge with, cooperating with, or participating in any proceeding before the Equal Employment
Opportunity Commission or a state fair 

  
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employment practices agency (except that you acknowledge that you may not recover any monetary benefits in connection with any such claim, charge or proceeding). 

 

	 	•	 	Continuing Obligations—You acknowledge your obligation to keep confidential and not to use or disclose any and all non-public information concerning the Company and Diotima that you acquired during
the course of your employment with the Company, including, but not limited to, any non-public information concerning the Company’s and/or Diotima’s business affairs, business prospects, and financial condition, except to the extent
disclosure may be required by order of a court of competent jurisdiction, in which event any such disclosure must be subject to all applicable judicial protection available for like material and you must provide reasonable advance notice to the
Company and/or Diotima. You further acknowledge and reaffirm your obligations set forth in the Confidentiality, Inventions, Non-Competition and Non-Solicitation Agreement you executed for the benefit of the Company, which remain in full force and
effect. 

  

	 	•	 	Non-Disparagement—You understand and agree that you will not, in public or private, make any false, disparaging, derogatory or defamatory statements to any person or entity, including, but not limited
to, any media outlet, industry group, financial institution or current or former employee, board member, consultant, client or customer of the Company, regarding the Company or any of the other Released Parties, or regarding the Company’s or
Diotima’s business affairs, business prospects, or financial condition. The Company will, in turn, instruct those individuals to whom it makes privy the terms of this letter agreement to refrain from making any false, disparaging or derogatory
statements about you. 

  

	 	•	 	Continued Assistance—You agree that after the Termination Date you will provide all reasonable cooperation to the Company in assisting with the transition of your job duties. 

 

	 	•	 	Cooperation—To the extent permitted by law, you agree to reasonably cooperate with the Company and/or Diotima in the defense or prosecution of any claims or actions which may be brought in the future
against or on behalf of the Company and/or Diotima, whether before a state or federal court, any state or federal government agency, or a mediator or arbitrator. Your reasonable cooperation in connection with such claims or actions shall include,
but not be limited to, being available to meet with counsel to prepare its claims or defenses, to prepare for trial or discovery or an administrative hearing or a mediation or arbitration and to act as a witness when requested by the Company and/or
Diotima at reasonable times designated by the Company and/or Diotima. For your cooperation, the Company agrees to reimburse you for reasonably necessary and documented travel, food, and lodging expenses. You agree that you will notify the Company
or, if applicable, Diotima promptly in the event that you are served with a subpoena or in the event that you are asked to provide a third party with information concerning any actual or potential complaint or claim against the Company and/or
Diotima. 

  

	 	•	 	 Return of Company Property—You confirm that you have returned to the Company all keys, files, records (and copies thereof),
equipment (including, but not limited to, computer hardware, software and printers, wireless handheld devices, cellular phones, pagers, etc.), Company identification, and any other Company-owned property in your possession or control and have left
intact all electronic Company documents, including but not limited to those that you developed or helped to develop during your employment. You further confirm that you have cancelled all accounts for your benefit,

  
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if any, in the Company’s name, including but not limited to, credit cards, telephone charge cards, cellular phone and/or pager accounts, and computer accounts. 

 

	 	•	 	Business Expenses and Final Compensation—You acknowledge that you have been reimbursed by the Company for all business expenses you incurred in conjunction with the performance of your employment and
submitted to the Company as of the Termination Date. The Company will also reimburse you, in accordance with the terms and conditions of its expense reimbursement policy and practice, for all reasonable business expenses you incurred during and in
conjunction with your employment but did not submit as of the Termination Date, provided you submit such expenses by close of business on April 4, 2013. You acknowledge that you have received payment in full for all services rendered in
conjunction with your employment by the Company, including payment for all wages (including overtime), bonuses, and accrued, unused vacation time, and that no other compensation is owed to you except as provided herein. 

 

	 	•	 	Amendment and Waiver—This letter agreement shall be binding upon the parties and may not be modified in any manner, except by an instrument in writing of concurrent or subsequent date signed by duly
authorized representatives of the parties hereto. This letter agreement is binding upon and shall inure to the benefit of the parties and their respective agents, assigns, heirs, executors, successors and administrators. No delay or omission by the
Company in exercising any right under this letter agreement shall operate as a waiver of that or any other right. A waiver or consent given by the Company on any one occasion shall be effective only in that instance and shall not be construed as a
bar to or waiver of any right on any other occasion. 

  

	 	•	 	Validity—Should any provision of this letter agreement be declared or be determined by any court of competent jurisdiction to be illegal or invalid, the validity of the remaining parts, terms or
provisions shall not be affected thereby and said illegal or invalid part, term or provision shall be deemed not to be a part of this letter agreement. 

  

	 	•	 	Confidentiality—To the extent permitted by law, you understand and agree that as a condition for payment to you of the severance benefits herein described, the terms and contents of this letter
agreement, and the contents of the negotiations and discussions resulting in this letter agreement, shall be maintained as confidential by you and your agents and representatives and shall not be disclosed except as otherwise agreed to in writing by
the Company. 

  

	 	•	 	Nature of Agreement—You understand and agree that this letter agreement is a severance agreement and does not constitute an admission of liability or wrongdoing on the part of the Company.

  

	 	•	 	Acknowledgments and Voluntary Assent—You acknowledge that you have been given at least seven (7) days to consider this letter agreement, and that the Company is hereby advising you to consult
with an attorney of your own choosing prior to signing this letter agreement. You affirm that no other promises or agreements of any kind have been made to or with you by any person or entity whatsoever to cause you to sign this letter agreement,
and that you fully understand the meaning and intent of this letter agreement. You further state and represent that you have carefully read this letter agreement, understand the contents herein, freely and voluntarily assent to all of the terms and
conditions hereof, and sign your name of your own free act. 

  

	 	•	 	 Applicable Law—This letter agreement shall be interpreted and construed by the laws of the Commonwealth of Massachusetts,
without regard to conflict of laws 

  
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provisions. You hereby irrevocably submit to and acknowledge and recognize the jurisdiction of the courts of the Commonwealth of Massachusetts, or if appropriate, a federal court located in the
Commonwealth of Massachusetts (which courts, for purposes of this letter agreement, are the only courts of competent jurisdiction), over any suit, action or other proceeding arising out of, under or in connection with this letter agreement or the
subject matter hereof. 

  

	 	•	 	Entire Agreement—This letter agreement contains and constitutes the entire understanding and agreement between the parties hereto with respect to your severance benefits and the settlement of claims
against the Company and cancels all previous oral and written negotiations, agreements, and commitments in connection therewith. Nothing in this paragraph, however, shall modify, cancel or supersede your obligations set forth in paragraph 4 above.
For the avoidance of doubt, your September 7, 2011 Offer Letter is terminated as of March 27, 2013 and is of no further force or effect. 

  

	 	•	 	Tax Acknowledgement- In connection with the severance benefits provided to you pursuant to this letter agreement, the Company shall withhold and remit to the tax authorities the amounts required under
applicable law, and you shall be responsible for all applicable taxes with respect to such severance benefits under applicable law. You acknowledge that you are not relying upon the advice or representation of the Company with respect to the tax
treatment of any of the severance benefits set forth in paragraph 2 of this letter agreement. 

 If you have any questions
about the matters covered in this letter agreement, please call me. 
  

			
	Very truly yours,
		
	By:	 	/s/ Seth L. Harrison
		 	 Seth L. Harrison, MD
 Chairman of the
Board

 I hereby agree to the terms and conditions set forth alive. I intend that this letter agreement become a
binding agreement between me and the Company. 
  

					
	 /s/ Martin D. Williams
	  		  	 4/4/13

	 Martin D. Williams
	  		  	Date

 To be returned by April 4, 2013 

  
 - 5 -EX-10.11

 Exhibit 10.11 
  

 
 July 19, 2012 
 Adrian
Senderowicz, MD 
 200 Blue Spruce Drive 
 Kennett Square, PA
19348 
 Dear Adrian: 
 It is my pleasure to extend to you this
offer of employment with Tokai Pharmaceuticals, Inc. (the “Company”). On behalf of the Company, I set forth below the terms of your employment: 
  

	 	1.	Employment. You will be employed to serve on a full-time basis as the Company’s Vice President, Medical Development and Chief Medical Officer (“CMO”), effective August 6, 2012. As Vice
President, Medical Development and CMO, you will be responsible for performing those duties customary of someone in your position, plus such other duties as may from time to time be assigned to you by the Company. You shall report to the Chief
Executive Officer or his/her designee, and shall work out of the Company’s Massachusetts office. You agree to devote your full business time, best efforts, skill, knowledge, attention and energies to the advancement of the Company’s
business and interests and to the performance of your duties and responsibilities as an employee of the Company. You agree to abide by the rules, regulations, instructions, personnel practices and policies of the Company and any changes therein that
may be adopted from time to time by the Company, in each case as provided to you. 

  

	 	2.	Base Salary. Your base salary will be at the rate of $22,916.67 per monthly pay period (which if annualized equals $275,000), less all applicable taxes and withholdings, to be paid in
installments in accordance with the Company’s regular payroll practices. Such base salary may be adjusted from time to time in accordance with normal business practices and in the sole discretion of the Company. 

 

	 	3.	Discretionary Bonus. Following the end of each calendar year and subject to the approval of the Board of Directors of the Company (the “Board”), you will be eligible for a retention and
performance bonus of up to 20% of your annualized base salary. The bonus, if any, you receive for a calendar year will be based on both your individual performance and the Company’s performance that year, as determined by the Company in
its sole discretion. In any event, you must be an active employee of the Company on the date any bonus is distributed in order to be eligible for and to earn any bonus award, as it also serves as an incentive to remain employed by the Company. Any
bonus would be pro-rated for the 2012 calendar year. 

  

	 	4.	 Relocation. In order to assist with your relocation to Massachusetts, the Company will reimburse you up to $50,000 for all reasonable
relocation expenses incurred by you 

  

	 	
prior to September 1, 2013, unless otherwise agreed with the CEO, including costs incurred by you in maintaining a temporary residence in the Greater Boston Area, following your submission
of documentation evidencing such expenses. If, within 12 months following your first day of employment, you resign or the Company terminates your employment for Cause (as defined below), you will be obligated to repay to the Company , within thirty
(30) days following your separation, a pro rata portion (based on the number of days you were employed) of the relocation expenses for which you were reimbursed. 

 

	 	5.	Stock Options. Subject to approval by the Board, the Company will grant to you a stock option (the “Stock Option”) to purchase 928,659 shares of common stock of the Company (which represents one
percent (1%) of the fully diluted capital of the company) (subject to appropriate adjustment for stock splits, stock dividends, combinations, recapitalizations and similar transactions affecting the common stock of the Company after the date
hereof) under the Company’s 2007 Stock Incentive Plan (the “Option Plan”), at an exercise price equal to the fair market value per share of the common stock of the Company on the date of grant, as determined by the Board. 12.5% of the
shares subject to the Stock Option shall become exercisable on the six- month anniversary of the commencement of your employment, subject to your continuing employment with the Company, and an additional 1/48th of the shares subject to the Stock Option shall become exercisable on the first day of each successive month thereafter, subject to your continuing employment with the Company. The terms of the
Stock Option will be set forth in an option agreement consistent with the 2007 Stock Incentive Plan. 

  

	 	6.	Benefits. You may participate in any and all benefit programs that the Company establishes and makes available to its employees from time to time, provided that you are eligible under (and subject to all
provisions of) the plan documents that govern those programs. Benefits are subject to change at any time in the Company’s sole discretion. 

  

	 	7.	Vacation. You will be eligible for a maximum of four (4) weeks of paid vacation per calendar year to be taken at such tunes as may be approved in advance by the Company. The number of vacation days
for which you are eligible shall accrue at the rate of 1.67 days per month that you are employed during such calendar year. Pursuant to Company policy, vacation time cannot be carried over from year to year. 

 

	 	8.	Confidentiality, Inventions, Non-Competition and Non-Solicitation Agreement. As a condition of your employment, you will be required to execute the enclosed Confidentiality, Inventions, Non-Competition and
Non-Solicitation Agreement (the “Non-Competition Agreement”). 

  

	 	9.	No Conflict. You represent that you are not bound by any employment contract, restrictive covenant or other restriction preventing you from entering into employment with or carrying out your
responsibilities for the Company, or which is in any way inconsistent with the terms of this offer letter. 

  
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	 	10.	Proof of Legal Right to Work. You agree to provide to the Company, within three (3) days of your date of hire, documentation proving your eligibility to work in the United States, as required by the
Immigration Reform and Control Act of 1986. You may need a work visa in order to be eligible to work in the United States. If that is the case, your employment with the Company will be conditioned upon your obtaining a work visa in a timely manner
as determined by the Company. 

  

	 	11.	At-Will Employment. This letter shall not be construed as an agreement, either express or implied, to employ you for any stated term, and shall in no way alter the Company’s policy of employment
at-will, under which both the Company and you remain free to end the employment relationship for any reason, at any time, with or without cause or notice. Although your job duties, title, compensation and benefits, as well as the Company’s
personnel policies and procedures, may change from time to time, the “at-will” nature of your employment may only be changed by a written agreement signed by you and the President and Chief Executive Officer of the Company that expressly
states the intention to modify the at-will nature of your employment. Similarly, nothing in this letter shall be construed as an agreement, either express or implied, to pay you any compensation or grant you any benefit beyond the end of your
employment with the Company, except as otherwise explicitly set forth herein. This letter supersedes all prior understandings, whether written or oral, relating to the terms of your employment. 

 

	 	12.	 Termination Without Cause. In the event the Company terminates your employment without “Cause” (as defined below), the Company
will, during the “Severance Period” (as defined below), continue to pay to you as severance pay your then current base salary (the “Severance Pay”). The Severance Pay is contingent upon your executing and allowing to become
effective (within 60 days following your termination or such shorter period as the Company may specify) a severance and release of claims agreement provided by the Company (the “Severance Agreement”). As used herein, the “Severance
Period” is the period beginning on the effective date of the Severance Agreement and ending on the earlier of (x) six (6) months following the effective date of the Severance Agreement, or (y) the date on which you commence
employment with, or commence working as a consultant or independent contractor for, another employer or entity. You are required to immediately provide the Company with written notice upon your commencement of employment with or provision of
services to another person, employer, or entity. Any Severance Pay hereunder will be subject to all applicable taxes and withholdings and will be payable in installments in accordance with the Company’s then-current payroll practices over the
course of the Severance Period, subject to the terms and conditions set forth in paragraph 13 below. As used herein, the term “Cause” means; (a) your conviction of, or plea of guilty or nolo contendere to, any crime involving
dishonesty or moral turpitude or any felony; or (b) a good faith finding by the Company that you have (i) engaged in dishonesty, willful misconduct or gross negligence in connection with the performance of your duties or services to the
Company; (ii) breached your Non-Competition Agreement; (iii) violated a Company policy or procedure, including without limitation a policy prohibiting harassment and discrimination or concerning drugs and alcohol; and/or (iv) failed
to 

  
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satisfactorily perform your assigned duties after notice and a period of fifteen (15) days to cure. 

  

	 	13.	Section 409A. 

  

	 	a.	Six Month Delay. For purposes of this letter, a termination of employment means a “separation from service” as defined in Section 409A of the Internal Revenue Code of 1986, as amended (the
“Code “). If and to the extent any portion of any payment, compensation or other benefit provided to the you in connection with your separation from service (as defined in Section 409A of Code) is determined to constitute
“nonqualified deferred compensation” within the meaning of Section 409A and you are a specified employee as defmed in Section 409A(a)(2)(B)(i) of the Code, as determined by the Company in accordance with its procedures, by which
determination you hereby agree that your are bound, such portion of the payment, compensation or other benefit will be paid within ten (10) days following the earlier of (i) the day that is six (6) months plus one (1) day after
the date of separation from service (as determined under Section 409A) or (ii) the date of your death (as applicable, the “New Payment Date”). The aggregate of any payments that otherwise would have been paid to you during
the period between the date of separation from service and the New Payment Date will be paid to you in a lump sum in the first payroll period beginning after such New Payment Date, and any remaining payments will be paid on their original schedule.

  

	 	b.	General 409A Principles. For purposes of this letter, each amount to be paid or benefit to be provided will be construed as a separate identified payment for purposes of Section 409A, and any payments that
are due within the “short term deferral period” as defined in Section 409A or are paid in a manner covered by Treas. Reg. Section 1.409A l(b)(9)(iii) will not be treated as deferred compensation unless applicable law requires
otherwise. Neither the Company nor you will have the right to accelerate or defer the delivery of any such payments or benefits except to the extent specifically permitted or required by Section 409A. This letter is intended to comply with the
provisions of Section 409A and the letter will, to the extent practicable, be construed in accordance therewith. Terms defined in this letter will have the meanings given such terras under Section 409A if and to the extent required to
comply with Section 409A. In any event, the Company makes no representations or warranty and will have no liability to you or any other person if any provisions of or payments under this letter are determined to constitute deferred compensation
subject to Code Section 409A but not to satisfy the conditions of that section. 

 If this letter correctly sets forth the terms under
which you will be employed by the Company, please sign the enclosed duplicate of this letter in the space provided below and return it to me, along with a signed copy of the Non-Competition Agreement. If you do not accept this offer by July 24,
2012, the offer will be deemed withdrawn. This offer is contingent on satisfactory reference checks and approval by the Board. 

  
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	Sincerely,
		
	By:	 	/s/ Martin Williams
		 	 Martin Williams
 President and Chief
Executive Officer

 The foregoing correctly sets forth the terms of my at-will employment with Tokai Pharmaceuticals, Inc. I am not relying
on any representations other than those set forth above. 
  

					
	 /s/ Adrian Senderowicz
	  		  	 7/19/2012

	Adrian Senderowicz, MD	  		  	Date

  
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