Document:

Exhibit 10.1

 

GUARDION HEALTH SCIENCES, INC.

 

SECURITIES PURCHASE AGREEMENT

 

This SECURITIES PURCHASE
AGREEMENT (the “Agreement”), dated as of March [__], 2019, is entered into by and between Guardion Health Sciences,
Inc., a Delaware corporation (“SELLER”), and each individual or entity named on the signature pages attached hereto
(each, a “PURCHASER” and all of such individuals or entities, the “PURCHASERS”).

 

WITNESSETH

 

A.       WHEREAS,
subject to the terms and conditions set forth in this Agreement and pursuant to Section 4(a)(2) of the Securities Act of 1933,
as amended (the “Securities Act”), and Rule 506 promulgated thereunder, the SELLER desires to issue and sell to
PURCHASER, and PURCHASER desires to purchase from SELLER, securities of SELLER as more fully described in this Agreement (the “Placement”).

 

B.       WHEREAS,
SELLER is selling (i) a debenture, in the form attached hereto as Exhibit D (the “Debenture”), which Debenture shall
be convertible into shares of its Common Stock, $0.001 par value (the “Conversion Shares”) and (ii) a warrant, in the
form attached hereto as Exhibit E (the “Warrant”), exercisable for Shares (the “Warrant Shares,” and collectively
with the Debenture, the Conversion Shares and the Warrant, the “Securities”), and SELLER desires to issue and PURCHASER
desires to purchase the Securities on the terms and conditions hereinafter set forth.

 

AGREEMENT

 

NOW THEREFORE, in consideration
of the recitals (each of which is incorporated herein by this reference), covenants, conditions, and promises contained herein,
and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto
agree as follows:

 

ARTICLE 1

SALE AND PURCHASE OF THE SECURITIES

 

1.1       Sale
of the Securities. Subject to the terms and conditions of this Agreement, each PURCHASER agrees, severally and not jointly,
to subscribe for and purchase, and upon acceptance by SELLER of each such subscription, it agrees to sell and issue to each PURCHASER,
the amount of Securities as set forth on the signature page to this Agreement. The Securities purchased shall be sold at a cash
purchase price as indicated on the signature page of this Agreement (the “Purchase Price”). The date upon which the
Company receives the Purchase Price, this Agreement having been fully executed and having all other required approvals obtained
or conditions completed, shall be deemed to be the effective date of this Agreement (the “Effective Date”).

 

1.2       Subscription
Acceptance. The Purchase Price will be paid into the accounts of SELLER, not into an escrow or other segregated account, at
the time of PURCHASER’s subscription and payment for the Securities issued and sold by SELLER pursuant to this Agreement.
The funds paid by the PURCHASERS to SELLER pursuant to the terms of this Agreement will be subject to the creditors of SELLER upon
payment by PURCHASER to SELLER. The purchase, sale and issuance of the Securities pursuant to this Agreement shall take place at
the offices of Sheppard, Mullin, Richter & Hampton LLP, 333 South Hope Street, Forty-Third Floor, Los Angeles, California 90071,
or such other location as the parties shall mutually agree, no later than the second business day following the satisfaction or
waiver of the conditions provided in Articles 5 and 6 of this Agreement.

 

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1.3        Form
of Payment; Delivery. Substantially concurrently with the delivery of an executed copy of this Agreement to SELLER, the PURCHASER
shall deliver to SELLER, for deposit in an account designated by SELLER, the PURCHASER’s Purchase Price against delivery
of the Securities being issued and sold.

 

ARTICLE 2

REPRESENTATIONS AND COVENANTS OF SELLER

 

The SELLER hereby represents
and warrants that:

 

2.1       It
shall transfer title, in and to the Securities, to the PURCHASER free and clear of all liens, security interests, pledges, encumbrances,
charges, restrictions, demands and claims, of any kind and nature whatsoever, whether direct or indirect or contingent, except
as set forth in Section 2.2 herein.

 

2.2       The
Debenture and the Warrant that SELLER shall deliver to the PURCHASER reflecting the Securities being issued to PURCHASER hereunder
shall have the following or such other appropriate legend:

 

THE SECURITIES REPRESENTED BY THIS
CERTIFICATE HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE
UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY,
MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS.

 

2.3       Due
Incorporation. SELLER is a corporation duly incorporated, validly existing and in good standing under the laws of the State
of Delaware and has the requisite corporate power to own its properties and to carry on its business as currently being conducted.
SELLER’s Bylaws, as amended and Certificate of Incorporation, as amended (the “Company Governing Documents”)
are available at the SEC’s website,www.sec.gov. SELLER, as of the date hereof, has one subsidiary, VectorVision Ocular Health,
Inc, a Delaware corporation. SELLER is duly qualified as a foreign corporation to do business and is in good standing in each jurisdiction
where the nature of the business conducted or property owned by it makes such qualification necessary, unless the failure to be
so qualified or in good standing, as the case may be, would not have or would not reasonably be expected to result in, (i) a
material adverse effect on the legality, validity or enforceability of this Agreement or any other document in connection with
the Placement, (ii) a material adverse effect on the results of operations, assets, business, prospects or financial condition
of SELLER, or (iii) a material adverse effect on SELLER’s ability to perform in any material respect on a timely basis
its obligations under this Agreement (any of (i), (ii) or (iii), constituting a “Material Adverse Effect”).

 

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2.4       Capitalization;
Ownership of Securities. The authorized capital stock of SELLER consists of 90,000,000 shares of common stock, par value
$0.001 per share (the “Common Stock”), and 10,000,000 shares of preferred stock, par value $0.001 per share (the
“Preferred Stock”). As of December 31, 2018, there are 22,845,002 shares of Common Stock issued and/or issuable
on a fully diluted basis, as follows: 20,564,328 shares of Common Stock are issued and outstanding, all of which are duly authorized,
validly issued, fully paid and nonassessable and were not issued in violation of any preemptive rights, and (ii) 2,280,674 shares
of Common Stock issuable upon exercise of outstanding warrants and stock options; (collectively the “Securities”).
Except for the transactions contemplated hereby and as described herein or in the SELLER’S SEC FILINGS (as defined below),
there are no outstanding options, warrants, convertible securities or other rights, agreements, arrangements or commitments relating
to the Common Stock or obligating SELLER to issue or sell any shares of Common Stock, or any other interest in, SELLER. All outstanding
shares of capital stock of SELLER were issued, sold and delivered in material compliance with all applicable federal and state
securities laws. No person has any right of first refusal, preemptive right, right of participation, or any similar right to participate
in the transactions contemplated by this Agreement or otherwise. The issue and sale of the Securities will not obligate SELLER
to issue shares of Common Stock or other securities to any person (other than the PURCHASERS) and will not result in a right of
any holder of SELLER securities to adjust the exercise, conversion, exchange or reset price under such securities.

 

2.5       Authority;
Enforceability. This Agreement and the Securities have been duly authorized, executed and delivered by SELLER and are valid
and binding agreements enforceable in accordance with their terms, subject to bankruptcy, insolvency, fraudulent transfer, reorganization,
moratorium and similar laws of general applicability relating to or affecting creditors’ rights generally and to general
principles of equity, and SELLER has full corporate power and authority necessary to enter into this Agreement and to perform its
obligations hereunder. All corporate action on the part of SELLER by its officers, directors and stockholders necessary for the
authorization, execution and delivery of, and the performance by SELLER of its obligations under this Agreement has been taken.

 

2.6       Consents.
No material consent, approval, authorization or order of any court, governmental agency or body or arbitrator having jurisdiction
over SELLER is required for execution of this Agreement and the performance of SELLER’s obligations hereunder.

 

2.7       No
Violation or Conflict. Assuming the representations and warranties of PURCHASER herein are true and correct, neither the execution
and delivery of this Agreement nor the issuance and sale of the Securities nor the performance of SELLER’s obligations under
this Agreement will:

 

(i)       violate,
conflict with, result in a material breach of, or constitute a material default (or an event which with the giving of notice or
the lapse of time or both would be reasonably likely to constitute a material default) or give to others any rights of termination,
amendment, acceleration or cancellation under (A) the Company Governing Documents of SELLER, (B) any material decree,
judgment, order, law, treaty, rule, regulation or determination applicable to SELLER of any court, governmental agency or body,
or arbitrator having jurisdiction over SELLER or any of its affiliates (including federal and state securities laws and regulations)
or over the properties or assets of SELLER or any of its affiliates, (C) the terms of any bond, debenture, note or any other
evidence of indebtedness, or any agreement, stock option or other similar plan, indenture, lease, mortgage, deed of trust or other
instrument to which SELLER or any of its affiliates is a party, by which SELLER or any of its affiliates is bound or affected,
or to which any of the properties or assets of SELLER or any of its affiliates is subject, or (D) the terms of any “lock-up”
or similar provision of any underwriting or similar agreement to which SELLER, or any of its affiliates is a party except, in the
case of clauses (A), (B), (C) or (D) above, the violation, conflict, breach, or default of which would not have a Material Adverse
Effect; or

 

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(ii)       result
in the creation or imposition of any material lien, charge or encumbrance upon the securities or any of the assets of SELLER or
any of its affiliates.

 

2.8       The
Securities. The Securities upon issuance:

 

(i)       are,
or will be, free and clear of any material security interests, liens, claims or other encumbrances, subject to restrictions upon
transfer under the Securities Act and any applicable state securities laws;

 

(ii)       have
been, or will be, duly and validly authorized and on the date of issuance will be duly and validly issued, fully paid and nonassessable;

 

(iii)       will
not have been issued or sold in violation of any preemptive or other similar rights of the holders of any securities of SELLER;
and

 

(iv)       will
not subject the holders thereof to personal liability by reason of being such holders.

 

2.9       Litigation.
Except as described in SELLER’S SEC FILINGS, there is no pending or, to the knowledge of SELLER, threatened material action,
suit, proceeding, inquiry, notice of violation, or investigation before any court, governmental or administrative agency or regulatory
body (federal, state, county, local or foreign), or arbitrator having jurisdiction over SELLER, or any of its affiliates that would
challenge the legality, validity or enforceability of this Agreement, or otherwise affect the execution by SELLER or the performance
by SELLER of its obligations under this Agreement. Except as disclosed herein or in the documents filed by SELLER with the Securities
and Exchange Commission (“SEC”) (“SELLER’S SEC FILINGS”), there is no pending or, to the knowledge
of SELLER, threatened action, suit, proceeding or investigation before any court, governmental agency or body, or arbitrator having
jurisdiction over SELLER, or any of its affiliates which litigation if adversely determined would have a Material Adverse Effect.

 

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2.10       Defaults;
Permits. SELLER is (i) not in material default under or in violation of any other material agreement or instrument to
which it is a party or by which it or any of its properties are bound or affected, which default or violation would have a Material
Adverse Effect, (ii) not in default with respect to any order of any court, arbitrator or governmental body or subject to
or party to any order of any court or governmental authority arising out of any action, suit or proceeding under any statute or
other law respecting antitrust, monopoly, restraint of trade, unfair competition or similar matters, or (iii) to its knowledge,
not in violation of any statute, rule or regulation of any governmental authority which violation would have a Material Adverse
Effect. SELLER possesses all material certificates, authorizations and permits issued by the appropriate federal, state or foreign
regulatory authorities necessary to conduct its business other than where the failure to possess such certificates, authorizations
or permits, individually or in the aggregate, has not had and would not reasonably be expected to have a Material Adverse Effect.
SELLER has not received any notice or otherwise become aware of any proceedings, inquiries or investigations relating to the revocation
or modification of any such certificate, authorization or permit.

 

2.11       No
General Solicitation. Neither SELLER nor any of its affiliates will take any action or steps that would cause the offer of
the Securities to be integrated with other offerings if such integration would eliminate the securities law exemption relied on
hereunder. Neither SELLER nor any of its affiliates, nor to SELLER’s knowledge, any person acting on its or their behalf,
has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D) in connection
with the offer or sale of the Securities.

 

2.12       Disclosure.
None of the representations and warranties of in this Agreement contains, or on the Effective Date will contain any untrue statement
of a material fact or omits, or will omit, to state any material fact required to be stated herein or therein in order for the
statements herein or therein, in light of the circumstances under which they were made, not to be misleading.

 

2.13       No
Undisclosed Liabilities. SELLER has no liabilities or obligations which are material, individually or in the aggregate, which
are not disclosed herein or in SELLER’S SEC FILINGS, other than those incurred in the ordinary course of SELLER’s businesses
since inception.

 

2.14       Intellectual
Property. SELLER owns, free and clear of claims or rights of any other person, with full right to use, sell, license, sublicense,
dispose of, and bring actions for infringement of, or has acquired licenses or other rights to use, all intellectual property necessary
for the conduct of its business as presently conducted, other than with respect to “off-the-shelf” software which is
generally commercially available and open source software which may be subject to one or more “general public” licenses.
The business of SELLER as presently conducted does not, to SELLER’s knowledge, infringe or conflict with any patent, trademark,
copyright, or trade secret rights of any third parties or any other intellectual property of any third parties. SELLER has not
received written notice from any third party asserting that any intellectual property owned or licensed by SELLER, or which SELLER
otherwise has the right to use, is invalid or unenforceable by SELLER and, to SELLER’s knowledge, there is no valid basis
for any such claim (whether or not pending or threatened). No claim is pending or, to SELLER’s knowledge, threatened against
SELLER nor has SELLER received any written notice or other written claim from any person asserting that any of SELLER’s present
or contemplated activities infringe or may infringe in any material respect any intellectual property of such person, and SELLER
is not aware of any infringement by any other Person of any material rights of SELLER under any intellectual property rights. SELLER
has taken all steps required in accordance with commercially reasonable business practice to establish and preserve its respective
ownership in its intellectual property and to keep confidential all material technical information developed by or belonging to
SELLER which has not been patented or copyrighted.

 

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2.15       Investment
Company Status. SELLER is not, and immediately after receipt of payment for the Securities will not be, an “investment
company” or an entity “controlled” by an “investment company” within the meaning of the Investment
Company Act of 1940, as amended (the “Investment Company Act”).

 

2.16       Taxes.
SELLER (i) has prepared in good faith and duly and timely filed all tax returns required to be filed by it or is on a current
extension and such returns are complete and accurate in all material respects and (ii) has paid all taxes required to have
been paid by it, except for taxes which it reasonably disputes in good faith or the failure of which to pay has not had or would
not reasonably be expected to have a Material Adverse Effect. SELLER has no liability with respect to accrued taxes in excess of
the amounts that are described as accrued in the most recent financial statements included in SELLER’S SEC FILINGS.

 

2.17       Transactions
with Related Persons. Except as described in the SELLER’S SEC FILINGS, no officer, director, employee or affiliate of
SELLER is or has taken any steps to become a party to any transaction with SELLER (other than for services as employees, officers
and directors), including any contract, agreement or other arrangement providing for the furnishing of services to or by, providing
for rental of real or personal property to or from, or otherwise requiring payments to or from any officer, director or such employee
or, to the knowledge of SELLER, any entity in which any officer, director, or any such employee has a substantial interest or is
an officer, director, trustee or partner.

 

2.18       Reissuance
of Securities. SELLER agrees to reissue certificates representing the Securities without the legends set forth above, (a) at
such time as the holder thereof is permitted to dispose of the Securities without volume or manner of sale restrictions pursuant
to Rule 144 in the opinion of counsel reasonably satisfactory to SELLER, or (b) upon resale subject to an effective registration
statement concerning the resale of the Securities is registered under the Securities Act. SELLER agrees to cooperate with PURCHASER
in connection with all resales pursuant to Rule 144 and to provide legal opinions, at SELLER’s expense, necessary to
allow such resales provided SELLER and its counsel receive reasonably requested written representations from PURCHASER and its
selling broker, if any.

 

2.19       Registration
Rights.

 

(i)       Subject
to Section 2.19(ii), within 240 days from the Effective Date, SELLER shall file with the SEC a registration statement on Form S-1
(the “Registration Statement”), registering for resale on a continuous or delayed basis in accordance with Securities
Act Rule 415(a)(i) the Securities issued to the PURCHASERS, and SELLER shall use its commercially reasonable efforts to cause the
Registration Statement to become effective as promptly as practicable following the date the Registration Statement is filed with
the SEC and which shall remain effective (or shall be replaced by another registration statement that is and remains effective
in accordance with Section 2.19(iii)) through and until at least the earlier of (i) the three (3)-year anniversary of the Effective
Date, (ii) the date on which all of the Securities covered by the Registration Statement have been sold or (iii) such time as the
Securities may be available for resale by the PURCHASERS pursuant to Rule 144 (as defined below) (the date of the earliest to occur
of the events in clause (i), (ii) or (iii) is referred to herein as the “Termination Date”). Notwithstanding anything
herein to the contrary, on and after the Termination Date, SELLER may file a post-effective amendment to the Registration Statement
(or any replacement thereof) in order to remove any remaining Securities therefrom (or replacement thereof) or otherwise take any
action required in order to terminate such Registration Statement (or replacement thereof), and will provide concurrent written
notice to PURCHASER. Each of the parties hereto shall bear all of their own expenses incurred in connection with the filing of
the Registration Statement and the resale of Securities (pursuant to the Registration Statement or otherwise).

 

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(ii)       Notwithstanding
anything to the contrary herein, as a condition to the filing of the Registration Statement, each PURCHASER shall provide to SELLER
on a timely basis a completed security holder questionnaire, a form of which is attached hereto as Exhibit A, with responses
subject to SELLER’s reasonable approval, and such other information that SELLER requires, including any information requested
or in response to any communication with the SEC, from the PURCHASERS in connection with the Registration Statement.

 

(iii)       Following
the filing of the Registration Statement, SELLER shall use its commercially reasonable efforts to prepare and file with the SEC
such amendments and supplements to the Registration Statement as may be necessary to keep the Registration Statement effective
during the relevant time period through the Termination Date and to comply with the provisions of the Securities Act with respect
to the disposition of all Securities covered by such Registration Statement. SELLER’s obligations under this Section 2.19
shall not apply with respect to any Securities which may be sold pursuant to Rule 144; provided, however, that SELLER shall reasonably
cooperate, and cause its transfer agent to reasonably cooperate, with the PURCHASER in any sale of such Securities pursuant to
Rule 144.

 

(iv)       Notwithstanding
anything to the contrary herein, for a total of not more than one hundred and twenty (120) days in any twelve (12)-month period,
SELLER may suspend the use of the Registration Statement in the event that SELLER determines in good faith that such suspension
is necessary or reasonably prudent to (i) delay disclosure of material non-public information concerning SELLER, the disclosure
of which at that time is not, in the opinion of the Board of Directors of SELLER, in the best interests of SELLER, or (ii) amend
or supplement the affected Registration Statement so that the Registration Statement shall not include any untrue statement of
a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, not
misleading (a “Permitted Delay”); provided, that SELLER shall notify the PURCHASER as promptly as reasonably practicable
prior to the commencement of any Permitted Delay to the extent permitted under applicable law. If SELLER suspends any Registration
Statement and requires the PURCHASER to cease sales of the Securities pursuant to the Registration Statement, SELLER shall, as
promptly as reasonably practicable following the termination of the circumstance which entitled SELLER to do so, take such actions
as may be reasonably necessary to file or reinstate the effectiveness of such Registration Statement and give written notice to
the PURCHASER authorizing the PURCHASER to resume sales pursuant to such Registration Statement.

 

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ARTICLE 3

REPRESENTATIONS AND COVENANTS OF PURCHASER

 

PURCHASER hereby
represents and warrants that:

 

3.1       PURCHASER
has been advised that the Securities have not been registered under the Securities Act, or qualified under the securities law of
any state, on the ground, among others, that no distribution or public offering of the Securities is to be effected and the Securities
will be issued by SELLER in connection with a transaction that does not involve any public offering within the meaning of Section 4(a)(2)
of the Securities Act and/or Rule 506 of Regulation D or other appropriate rule or regulation as promulgated by the SEC
under the Securities Act, and under any applicable state blue sky authority. PURCHASER understands that SELLER is relying in part
on PURCHASER’s representations as set forth herein for purposes of claiming such exemptions and that the basis for such exemptions
may not be present if, notwithstanding PURCHASER’s representations, PURCHASER has in mind merely acquiring Securities for
resale on the occurrence or nonoccurrence of some predetermined event. PURCHASER has no such intention.

 

3.2       PURCHASER
acknowledges that until such time as the Registration Statement described in Section 2.19 is deemed effective by the SEC, the Securities
will be “restricted securities” (as such term is defined in Rule 144 promulgated under the Securities Act (“Rule 144”)),
and that the Securities will include appropriate restrictive legends restricting the transfer of such Securities. PURCHASER also
acknowledges that (a) any resales of the Securities in compliance with Rule 144 requires a complicated legal and factual analysis
and (b) it has both the means and a full and fair opportunity to obtain United States securities counsel prior to any resale of
the Securities in compliance with Rule 144.

 

3.3       The
PURCHASER has the full right, power and authority to enter into this Agreement and to carry out and consummate the transaction
contemplated herein. This Agreement constitutes the legal, valid and binding obligation of PURCHASER.

 

3.4       The
PURCHASER has carefully reviewed the SELLER SEC FILINGS, in particular the sections of the SELLER SEC FILINGS entitled “Risk
Factors”.

 

3.5       The
office or offices of PURCHASER identified on the signature pages hereto as the address of PURCHASER is the location of its principal
place of business and such entity is duly organized in its state of formation.

 

3.6       With
respect to PURCHASER, no person or entity will have, as a result of the transactions contemplated by this Agreement, any valid
right, interest or claim against or upon SELLER or PURCHASER for any commission, fee or other compensation pursuant to any agreement,
arrangement or understanding entered into by or on behalf of PURCHASER.

 

3.7       PURCHASER
(i) has had no position, office or other material relationship within the past three years with SELLER or persons or entities
known to it to be affiliates of SELLER, and (ii) if PURCHASER is a member of the Financial Industry Regulatory Authority (“FINRA”)
or an associated person of a member of FINRA, PURCHASER, together with its affiliates and any other associated persons of such
member of FINRA, does not, and at the time of the acceptance by SELLER of PURCHASER’s subscription for Securities pursuant
to this Agreement will not, directly or indirectly have a beneficial interest (as determined under FINRA Rule 5130(i)(1))
of more than 50% of the outstanding voting securities of SELLER.

 

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3.8       The
PURCHASER acknowledges that investment in the Securities involves substantial risks and is suitable only for persons of adequate
financial means who can bear the economic risk of an investment in the Securities for an indefinite period of time and who can
afford to suffer a complete loss on their investment in the Securities. PURCHASER further represents that he, she or it:

 

(1)       has
adequate means of providing for its current needs and possible personal contingencies, has no need for liquidity in its investment
in the Securities, is able to bear the substantial economic risks of an investment in the Securities for an indefinite period,
and can afford to suffer a complete loss of its investment;

 

(2)       does
not have an overall commitment to investments which are not readily marketable that is disproportionate to its net worth, and that
its investment in the Securities will not cause such overall commitment to become excessive;

 

(3)       is
acquiring the Securities for its own account, for investment purposes only and not with a view toward resale, assignment or distribution
thereof, and no other person has a direct or indirect, beneficial interest, in whole or in part, in such Securities;

 

(4)       has
such knowledge and experience in financial, tax and business matters that he or she is capable of evaluating the merits and risks
of an investment in the Securities;

 

(5)       has
been given the opportunity to ask questions of and to receive answers from persons acting on the SELLER’S behalf concerning
the terms and conditions of this transaction and also has been given the opportunity to obtain any additional information which
the SELLER possesses or can acquire without unreasonable effort or expense. As a result, PURCHASER has available sufficient information
concerning the affairs of the SELLER and has been able to evaluate the merits and risks of the investment in the Securities; and

 

(6)       PURCHASER
has been advised by its own legal counsel, or has had the opportunity to engage its own legal counsel, with respect to this Agreement
and understands and agrees that (i) it has carefully read and fully understands all of the terms of this Agreement; and (ii) it
is under no disability or impairment that affects its decision to sign this Agreement and knowingly and voluntarily intends to
be legally bound by this Agreement.

 

3.9       PURCHASER
understands and acknowledges that ownership of any class of SELLER’s securities in certain amounts may subject PURCHASER
to reporting and other informational requirements imposed by Section 13 and Section 16 of the Securities Exchange Act of 1934,
as amended (the "Exchange Act"). In addition, without limiting the generality of the foregoing, Section 16(b) of the
Exchange Act imposes liability on company "insiders" for realizing short-swing profits relating to SELLER’s securities.
PURCHASER is responsible for any and all filing requirements under Section 13 and Section 16 of the Exchange Act. SELLER cannot
advise PURCHASER regarding, nor is SELLER responsible for, any PURCHASER filing requirements under Section 13 and Section 16 of
the Exchange Act. PURCHASER is urged to seek the advice of counsel with respect to the application of Section 13 and Section 16
of the Exchange Act to PURCHASER’s particular situation, as well as any other consequences arising under U.S. federal or
state securities laws or under the laws of any foreign jurisdiction.

 

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3.10       If
PURCHASER is not a United States person (as defined by Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended),
then:(a) PURCHASER hereby represents that it has satisfied itself as to the full observance of the laws of its jurisdiction in
connection with any invitation to subscribe for the Securities or any use of this Agreement, including (i) the legal requirements
within its jurisdiction for the purchase of the Securities, (ii) any foreign exchange restrictions applicable to such purchase,
(iii) any governmental or other consents that may need to be obtained, and (iv) the income tax and other tax consequences,
if any, that may be relevant to the purchase, holding, redemption, sale, or transfer of the Securities, (b) PURCHASER’s subscription
and payment for and continued beneficial ownership of the Securities will not violate any applicable securities or other laws of
the PURCHASER’s jurisdiction and (c)PURCHASER further represents that the representations and warranties set forth on Exhibit
B hereto are true and correct.

 

3.11       PURCHASER
agrees, in connection with SELLER’s contemplated initial public offering (the “IPO”), (i) not to sell, make short
sales of, loan, grant any options for the purchase of, or otherwise dispose of any Securities (other than those shares included
in the registration, if any) without the prior written consent of the SELLER or the underwriters managing the initial public offering
for one hundred eighty (180) days following the effective date of such registration and (ii) further agrees to execute the lock-up
agreement, attached hereto as Exhibit C which substantially reflects (i) above.

 

3.12       PURCHASER
represents that (i) PURCHASER had a prior pre-existing relationship with the Company under the U.S. securities laws and interpretations
and (ii) no Securities were offered or sold to PURCHASER by means of any form of general solicitation, and PURCHASER is not purchasing
the Securities as a result of any advertisement, article, notice or other communication regarding the Securities published in any
newspaper, magazine or similar media or broadcast over television or radio or presented at any seminar or, to the knowledge of
such PURCHASER, any other general solicitation or general advertisement. PURCHASER has not become interested in the offering of
the Securities as a result of SELLER’s registration statement on Form S-1 (file no. 333-228086) (the “Registration
Statement”) or any other registration statement of the Company filed with the SEC or any other securities agency or regulator.
PURCHASER understands that there are no assurances that the offering described in the Registration Statement, including the contemplated
listing of SELLER’s common stock on the NASDAQ Capital Market, will be successful.

 

ARTICLE 4

OTHER AGREEMENTS OF THE PARTIES

 

4.1       Form
D; Blue Sky Filings. SELLER shall timely file a Form D with respect to the Securities as required under Regulation D of
the Securities Act. SELLER shall take such action as SELLER shall reasonably determine is necessary in order to obtain an exemption
for sale to the PURCHASER under applicable securities or “Blue Sky” laws of the states of the United States.

 

4.2       Use
of Proceeds. SELLER shall use the proceeds from the sale of the Securities hereunder for general working capital purposes and
operating expenses. SELLER shall not use such proceeds: (a) for dividends or distributions on any Securities, (b) to repurchase
any Securities, or (c) for the redemption of any Securities.

 

    -10- 

     

    

 

ARTICLE 5

CONDITIONS PRECEDENT TO SELLER’S OBLIGATIONS TO SELL

 

The obligation of SELLER
hereunder to issue and sell the Securities to the PURCHASERS is subject to the satisfaction, at or before the acceptance of the
subscriptions by SELLER from PURCHASERS, of each of the following conditions, provided that these conditions are for SELLER’s
sole benefit and may be waived by SELLER at any time in its sole discretion:

 

5.1       Each
PURCHASER acquiring Securities shall have executed this Agreement and delivered it to SELLER.

 

5.2       Each
PURCHASER acquiring Securities shall have paid the PURCHASER’s Purchase Price to SELLER.

 

5.3       The
representations and warranties of the PURCHASERS acquiring Securities shall be true and correct in all material respects as of
the date when made and as of the acceptance by SELLER of PURCHASERS’ subscriptions as though made at that time (except for
representations and warranties that speak as of a specific date, which shall be true and correct as of such specific date), and
PURCHASERS shall have performed, satisfied and complied in all material respects with the covenants, agreements and conditions
required by this Agreement to be performed, satisfied or complied with by such PURCHASER at or prior to the acceptance of the PURCHASERS’
subscription for Securities by SELLER.

 

5.4       SELLER
shall have obtained all governmental, regulatory or third party consents and approvals necessary for the sale of the Securities.

 

5.5       No
statute, rule, regulation, executive order, decree, ruling or injunction shall have been enacted, entered, promulgated or endorsed
by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated
by this Agreement.

 

5.6       Since
the date of execution of this Agreement, no event or series of events shall have occurred that resulted, or could reasonably be
expected to result, in a Material Adverse Effect.

 

ARTICLE 6

CONDITIONS PRECEDENT TO PURCHASER’S OBLIGATIONS TO PURCHASE

 

The obligation of the
PURCHASERS hereunder to purchase the Securities is subject to the satisfaction, at or before the acceptance by SELLER of PURCHASERS’
subscription for Securities, of each of the following conditions (in addition to any other conditions precedent elsewhere in this
Agreement), provided that these conditions are for the benefit of the PURCHASERS acquiring Securities and may be waived by the
PURCHASERS, collectively, at any time in their sole discretion:

 

6.1       SELLER
shall have executed this Agreement and all exhibits hereto and delivered the same to the PURCHASERS.

 

    -11- 

     

    

 

6.2       SELLER
shall have delivered to the transfer agent for the Common Stock issuance instructions and all other documents required by such
transfer agent to issue by direct registration in book-entry form in PURCHASERS’ name the number of Securities that each
PURCHASER is purchasing.

 

6.3       The
representations and warranties of SELLER shall be true and correct in all material respects as of the date when made and as of
SELLER’s acceptance of PURCHASERS’ subscription for Securities as though made at that time (except for representations
and warranties that speak as of a specific date, which shall be true and correct as of such specific date) and SELLER shall have
performed, satisfied and complied in all material respects with the covenants, agreements and conditions required by this Agreement
to be performed, satisfied or complied with by SELLER at or prior to acceptance of such subscription.

 

ARTICLE 7

MISCELLANEOUS

 

7.1       Entire
Agreement. This Agreement sets forth the entire agreement and understanding of the parties hereto with respect to the transactions
contemplated hereby, and supersedes all prior agreements, arrangements and understandings related to the subject matter hereof.
No understanding, promise, inducement, statement of intention, representation, warranty, covenant or condition, written or oral,
express or implied, whether by statute or otherwise, has been made by any party hereto which is not embodied in this Agreement
or the written statements, certificates, or other documents delivered pursuant hereto or in connection with the transactions contemplated
hereby, and no party hereto shall be bound by or liable for any alleged understanding, promise, inducement, statement, representation,
warranty, covenant or condition not so set forth.

 

7.2       Waiver
and Amendment. Any term of this Agreement may be amended, terminated or waived only with the written consent of SELLER and
PURCHASER.

 

7.3       Notices.
All notices provided for in this Agreement shall be in writing signed by the party giving such notice, and delivered personally
or sent by overnight courier or sent by registered or certified mail (air mail if overseas), return receipt requested, electronic
mail or facsimile transmission. Notices shall be deemed to have been received on the date of personal delivery, electronic mail,
facsimile transmission, or if sent by overnight courier or messenger, shall be deemed to have been received on the next delivery
day after deposit with the courier, or if sent by certified or registered mail, return receipt requested, shall be deemed to have
been received on the third business day after the date of mailing. Notices shall be sent to the addresses set forth opposite to
each parties’ signature below.

 

7.4       Arbitration.
If a dispute or claim shall arise with respect to any of the terms or provisions of this Agreement, or with respect to the performance
by either of the parties under this Agreement, then either party may, by notice as herein provided, require that the dispute be
submitted under the Commercial Arbitration Rules of the American Arbitration Association to an arbitrator in good standing with
the American Arbitration Association within thirty (30) days after such notice is given. The written decision of the single
arbitrator ultimately appointed by or for both parties shall be binding and conclusive on the parties. Judgment may be entered
on such written decision by the single arbitrator in any court having jurisdiction and the parties consent to the jurisdiction
of the State of California for this purpose. Any arbitration undertaken pursuant to the terms of this section shall occur in a
venue determined by the SELLER.

 

    -12- 

     

    

 

7.5       Choice
of Law and Venue. This Agreement and the rights of the parties hereunder shall be governed by and construed in accordance with
the laws of the State of California including all matters of construction, validity, performance, and enforcement and without giving
effect to the principles of conflict of laws. Any action brought by any party hereto shall be brought in a venue determined by
the SELLER.

 

7.6       Jurisdiction.
The parties submit to the jurisdiction of the Courts of the State of California, County of San Diego, or a Federal Court empaneled
in the State of California, Southern District, for the resolution of all legal disputes arising under the terms of this Agreement,
including, but not limited to, enforcement of any arbitration award.

 

7.7       Counterparts.
This Agreement may be executed electronically or via facsimile and in one or more counterparts, each of which shall be deemed an
original, but all of which shall together constitute one and the same instrument.

 

7.8       Attorneys’
Fees. Except as otherwise provided herein, if a dispute should arise between the parties including, but not limited to arbitration,
the prevailing party shall be reimbursed by the non-prevailing party for all reasonable expenses incurred in resolving such dispute,
including reasonable attorneys’ fees exclusive of such amount of attorneys’ fees as shall be a premium for result or
for risk of loss under a contingency fee arrangement.

 

7.9       Taxes.
Any income taxes required to be paid in connection with this transaction shall be borne by the party required to make such payment.

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

 

    -13- 

     

    

 

IN WITNESS WHEREOF,
the parties hereto have caused this Stock Purchase Agreement to be duly executed by their respective authorized signatories as
of the date first indicated above.

 

	GUARDION HEALTH SCIENCES, INC.	 	Address for Notice:
	 	 	 	 
	 	 	 	15150 Avenue of Science, Suite 200
	By:	 	 	San Diego, CA 92128
	 	Name: Michael Favish	 	 
	 	Title: Chief Executive Officer	 	 

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGE FOR PURCHASER FOLLOWS]

 

    -14- 

     

    

 

[PURCHASER SIGNATURE PAGE TO GUARDION HEALTH
SCIENCES, INC.

SECURITIES PURCHASE AGREEMENT]

 

IN WITNESS WHEREOF,
the undersigned have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as
of the date first indicated above.

 

	Name of Purchaser :	 

 

	Signature of Authorized Signatory of Purchaser:	 

 

	Email Address of Authorized Signatory:	 

 

	Telephone Number of Authorized Signatory:	 

 

	Address for Notice to Purchaser:	 	 

 

Address for Delivery of Securities to Purchaser
(if not same as address for notice):

 

Purchaser’s Residential Address (if
not the same as the address for notice):

 

Purchase Price: $

 

Principal Amount of Debenture (same as Purchase
Price): $

 

    -15- 

     

    

 

Exhibit A

 

GUARDION HEALTH SCIENCES, INC.

 

Selling Stockholder Notice and Questionnaire

 

The undersigned (the
“Selling Stockholder”) beneficial owner of common stock (the “Registrable Securities”) of
GUARDION HEALTH SCIENCES, INC. (the “Company”), understands that the Company has filed or intends to file with
the Securities and Exchange Commission (the “Commission”) a registration statement (the “Registration
Statement”) for the registration and resale under Rule 415 of the Securities Act of 1933, as amended (the “Securities
Act”), of the Registrable Securities.

 

Certain legal consequences
arise from being named as a selling stockholder in the Registration Statement and the related prospectus. Accordingly, holders
and beneficial owners of Registrable Securities are advised to consult their own securities law counsel regarding the consequences
of being named or not being named as a selling stockholder in the Registration Statement and the related prospectus.

 

NOTICE

 

The undersigned beneficial
owner (the “Selling Stockholder”) of Registrable Securities hereby elects to include the Registrable Securities
owned by it in the Registration Statement.

 

    -16- 

     

    

 

The undersigned hereby provides the following
information to the Company and represents and warrants that such information is accurate:

 

QUESTIONNAIRE

 

		1.	Name.

 

		(a)	Full Legal Name of Selling Stockholder

 

	 
	 

 

		(b)	Full Legal Name of Registered Holder (if not the same as (a) above) through which Registrable Securities
are held:

 

	 
	 

 

		(c)	Full Legal Name of Natural Control Person (which means a natural person who directly or indirectly
alone or with others has power to vote or dispose of the securities covered by this Questionnaire):

 

	 
	 

 

2. Address for Notices to Selling
Stockholder:

 

	 
	 
	 
	
         

	 	 
	Fax:	 

 

	Contact Person:	 

 

3. Broker-Dealer Status:

 

		(a)	Are you a broker-dealer?

 

Yes  ̈
      No  ̈

 

		(b)	If “yes” to Section 3(a), did you receive your Registrable Securities as compensation
for investment banking services to the Company?

 

Yes  ̈
      No  ̈

 

    -17- 

     

    

 

		Note:	If “no” to Section 3(b), the Commission’s
staff has indicated that you should be identified as an underwriter in the Registration Statement.

 

		(c)	Are you an affiliate of a broker-dealer?

 

Yes  ̈
      No  ̈

 

		(d)	If you are an affiliate of a broker-dealer, do you certify that you purchased the Registrable Securities
in the ordinary course of business, and at the time of the purchase of the Registrable Securities to be resold, you had no agreements
or understandings, directly or indirectly, with any person to distribute the Registrable Securities?

 

Yes  ̈
      No  ̈

 

		Note:	If “no” to Section 3(d), the Commission’s
staff has indicated that you should be identified as an underwriter in the Registration Statement.

 

4. Beneficial Ownership of Securities
of the Company Owned by the Selling Stockholder.

 

Except as set forth below
in this Item 4, the undersigned is not the beneficial or registered owner of any securities of the Company.

 

		(a)	Type and Amount of securities beneficially owned by the Selling Stockholder:

 

	 
	 
	 

 

		(b)	Please indicate whether the Registrable
Securities will be beneficially owned with sole voting power, shared voting power, sole investment power and/or shared investment
power)1:

 

	 
	 
	 

 

5. Relationships with the Company:

 

Except as set forth below,
neither the undersigned nor any of its affiliates, officers, directors or principal equity holders (owners of 5% of more of the
equity securities of the undersigned) has held any position or office or has had any other material relationship with the Company
(or its predecessors or affiliates) during the past three years.

 

State any exceptions here:

 

	 
	 
	 

 

 

 

		1	If not indicated otherwise, it will be assumed that the
Selling Stockholder possesses sole voting and sole investment power with respect to all securities listed herein.

 

    -18- 

     

    

 

6. Plan of Distribution:

 

Except as set forth
below, the undersigned, (including its donees or pledgees) intends to distribute the Registrable Securities held by him, her or
it that are registered pursuant to the Registration Statement only as follows (if at all): Such Registrable Securities may be sold
from time to time directly by the undersigned or, alternatively, through underwriters, broker-dealers or agents or through a combination
of these methods, including, without limitation, pursuant to a trading plan adopted pursuant to Rule 10b5-1 under the Securities
Exchange Act of 1934, as amended. If the Registrable Securities are sold through underwriters or broker-dealers, the undersigned
Selling Stockholder will be responsible for underwriting discounts or commissions or agent’s commissions. Such Registrable
Securities may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of sale, at varying
prices determined at the time of sale, or at negotiated prices. Such sales may be effected in transactions (which may involve block
transactions) (i) on any national securities exchange or quotation service on which the Registrable Securities may be listed or
quoted at the time of sale, (ii) in the over-the-counter market, (iii) in transactions otherwise than on such exchanges or services
or in the over-the-counter market, or (iv) through privately negotiated transactions. In connection with sales of the Registrable
Securities or otherwise, the undersigned Selling Stockholder may enter into derivative hedging transactions with broker-dealers
or other third parties, which may in turn engage in short sales of the Registrable Securities and deliver Registrable Securities
to close out such short positions, or loan or pledge Registrable Securities to broker-dealers that in turn may sell such securities.

 

State any exceptions
here:

 

	 
	 
	 

 

    -19- 

     

    

 

The undersigned agrees
to promptly notify the Company of any material inaccuracies or changes in the information provided herein that may occur subsequent
to the date hereof at any time while the Registration Statement remains effective; provided, that the undersigned shall not be
required to notify the Company of any changes to the number of securities held or owned by the undersigned or its affiliates.

 

The undersigned acknowledges
that it understands its obligation to comply with the provisions of the Securities Exchange Act of 1934, as amended, and the rules
thereunder relating to stock manipulation, particularly Regulation M thereunder (or any successor rules or regulations), in connection
with any offering of the Registrable Securities pursuant to the Registration Statement. The undersigned agrees that neither it
nor any person acting on its behalf will engage in any transaction in violation of such provisions.

 

As
a condition for the validity of this questionnaire for the purposes of the Stock Purchase Agreement to which this questionnaire
is attached, the undersigned Selling Stockholder hereby agrees to, severally and not jointly, indemnify and hold harmless the Company
and, where applicable, its directors and officers and any person who controls the Company within the meaning of Section 15 of the
Securities Act or Section 20 of the Securities Exchange Act of 1934, as amended, and the successors and assigns of all of the foregoing
persons from any and all losses directly or indirectly caused by any untrue statement or alleged untrue statement of a material
fact contained in the Registration Statement, the prospectus included therein, or any prospectus supplement and, if applicable
and permitted to be used in connection with any transaction, any free writing prospectus, including in each case, any amendment
or supplement thereto, or any omission or alleged omission to state therein a material fact necessary to make the statements therein,
in light of the circumstances under which they were made, not misleading (each, a “Violation”), in each case to the
extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with the information included in
this Selling Stockholder Notice and Questionnaire, which the undersigned Selling Stockholder is hereby informed is expressly for
use in the Registration Statement and the prospectus included therein, and any other written information (if any) furnished by
such Selling Stockholder relating to such Selling Stockholder and the ownership of its shares under an instrument duly executed
and delivered by such Selling Stockholder to the Company and stated to be expressly for use in connection with the Registration
Statement and the prospectus included therein.

 

By signing below, the
undersigned consents to the disclosure of the information contained herein in its answers to Items 1 through 6 and the inclusion
of such information in the Registration Statement and the related prospectus and any amendments or supplements thereto. The undersigned
understands that such information will be relied upon by the Company in connection with the preparation or amendment of the Registration
Statement and the related prospectus and any amendments or supplements thereto.

 

    -20- 

     

    

 

IN WITNESS WHEREOF
the undersigned, by authority duly given, has caused this Notice and Questionnaire to be executed and delivered either in person
or by its duly authorized agent.

 

	Date:	 	 	Beneficial Owner:	 

 

	 	 	By:	 
	 	 	 	Name: 
	 	 	 	Title: 
	 	 	 	 
	 	 	 	 

 

PLEASE FAX A COPY (OR EMAIL A .PDF COPY)
OF THE COMPLETED AND EXECUTED NOTICE AND QUESTIONNAIRE TO:

 

Sheppard Mullin Richter & Hampton
LLP

333 South Hope Street 

Forty-Third Floor 

Los Angeles, California 90071

Attention: David Sunkin, Esq.

Email: DSunkin@sheppardmullin.com

 

    -21- 

     

    

 

Exhibit B

 

Investment
Representations. In connection with the acquisition of the Shares, PURCHASER represents to SELLER the following:

 

Not a “U.S.
Person”. PURCHASER is not a “U.S. Person” as defined in Rule 902 of Regulation S promulgated under the Securities
Act of 1933, as amended (the “Securities Act”), and was not organized under the laws of any United States jurisdiction.
At the time the purchase order for this transaction was originated, PURCHASER was outside the United States.

 

Intent.
PURCHASER is purchasing the Shares solely for investment purposes, for the PURCHASER’s own account and not for the account
or benefit of any U.S. Person, and not with a view towards the distribution or dissemination thereof and PURCHASER has no present
arrangement to sell the Shares to or through any person or entity. PURCHASER understands that the Shares must be held indefinitely
unless such the Shares are resold in accordance with the provisions of Regulation S, are subsequently registered under the Securities
Act or an exemption from registration is available.

 

Restrictions
on Transfer. PURCHASER understands that the Shares are being offered in a transaction not involving a public offering in the
United States within the meaning of the Securities Act. The Shares have not been registered under the Securities Act, and, if in
the future PURCHASER decides to offer, resell, pledge or otherwise transfer the Shares, such Shares may be offered, resold, pledged
or otherwise transferred only (i) pursuant to an effective registration statement filed under the Securities Act, (ii) to a non-U.S.
Person in an offshore transaction in accordance with Rule 903 or Rule 904 of Regulation S of the Securities Act, (iii) pursuant
to the resale limitations set forth in Rule 905 of Regulation S, (iv) pursuant to an exemption from registration under the Securities
Act provided by Rule 144 thereunder (if available), or (v) pursuant to any other exemption from the registration requirements of
the Securities Act, and in each case in accordance with any applicable securities laws of any state of the United States or any
other jurisdiction. PURCHASER acknowledges, agrees and covenants that it will not engage in hedging transactions with regard to
the Shares prior to the expiration of the distribution compliance period specified in Rule 903 of Regulation S promulgated under
the Securities Act, unless in compliance with the Securities Act. PURCHASER agrees that if any transfer of its Shares or any interest
therein is proposed to be made, as a condition precedent to any such transfer, PURCHASER may be required to deliver to SELLER an
opinion of counsel satisfactory to SELLER. Absent registration or another exemption from registration, PURCHASER agrees that it
will not resell the securities constituting the Shares to U.S. Persons or within the United States.

 

Sophisticated
Investor.

 

PURCHASER is sophisticated
in financial matters and is able to evaluate the risks and benefits of the investment in the Shares.

 

PURCHASER is able
to bear the economic risk of its investment in the Shares for an indefinite period of time because none of the Shares have been
registered under the Securities Act and therefore cannot be sold unless subsequently registered under the Securities Act or an
exemption from such registration is available.

 

    -22- 

     

    

 

Independent
Investigation. PURCHASER, in making the decision to purchase the Shares, has relied upon an independent investigation of SELLER
and has not relied upon any information or representations made by any third parties or upon any oral or written representations
or assurances from SELLER, its officers, directors or employees or any other representatives or agents of SELLER, other than as
set forth in this Agreement. PURCHASER is familiar with the business, operations and financial condition of SELLER and has had
an opportunity to ask questions of, and receive answers from, SELLER’s officers and directors concerning SELLER and the terms
and conditions of the offering of the Shares and has had full access to such other information concerning SELLER as the PURCHASER
has requested.

 

Authority.
This Agreement has been validly authorized, executed and delivered by PURCHASER and is a valid and binding agreement enforceable
in accordance with its terms, subject to the general principles of equity and to bankruptcy or other laws affecting the enforcement
of creditors’ rights generally. The execution, delivery and performance of this Agreement by PURCHASER does not and will
not conflict with, violate or cause a breach of any agreement, contract or instrument to which PURCHASER is a party.

 

No Legal Advice
from Company or its Legal Counsel. PURCHASER acknowledges that it has had the opportunity to review this Agreement and the
transactions contemplated by this Agreement and the other agreements entered into between the parties hereto with PURCHASER’s
own legal counsel and investment and tax advisors. Except for any statements or representations of SELLER made in this Agreement
and the other agreements entered into between the parties hereto, PURCHASER is relying solely on such counsel and advisors and
not on any statements or representations of SELLER or any of its representatives or agents or legal counsel for legal, tax or investment
advice with respect to this investment, the transactions contemplated by this Agreement or the securities laws of any jurisdiction.

 

Reliance on
Representations and Warranties. PURCHASER understands that the Shares are being offered and sold to PURCHASER in reliance on
specific provisions of United States federal securities laws and that SELLER is relying upon the truth and accuracy of the representations,
warranties, agreements, acknowledgments and understandings of PURCHASER set forth in this Agreement in order to determine the applicability
of such provisions.

 

No Advertisements.
PURCHASER is not subscribing for the Shares as a result of or subsequent to any advertisement, article, notice or other communication
published in any newspaper, magazine, or similar media or broadcast over television or radio, or presented at any seminar or meeting.
PURCHASER acknowledges and agrees that neither SELLER, any of its respective affiliates nor any person acting on behalf of any
of the foregoing made any “directed selling efforts” as defined in Rule 902 of Regulation S promulgated under the Securities
Act in the United States.

 

Legend.
PURCHASER acknowledges and agrees that the Shares shall bear restricted legends, in the form and substance as set forth in this
Agreement, prohibiting the offer, sale, pledge or transfer of the securities, except (i) pursuant to an effective registration
statement filed under the Securities Act, (ii) in accordance with the applicable provisions of Regulation S, promulgated under
the Securities Act, (iii) pursuant to an exemption from registration provided by Rule 144 under the Securities Act (if available),
and (iv) pursuant to any other exemption from the registration requirements of the Securities Act.

 

    -23- 

     

    

 

Restrictive
Legends. In order to reflect the restrictions on the disposition of the Shares, the stock certificates for the Shares will
be endorsed with restrictive legends, including the following or such other appropriate legends:

 

“THE SHARES
REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY
NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT (A) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
FILED UNDER THE ACT, (B) TO A NON U.S. PERSON IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH RULE 903 OR RULE 904 OF REGULATION
S UNDER THE ACT, (C) PURSUANT TO THE RESALE LIMITATIONS SET FORTH IN RULE 905 OF REGULATION S UNDER THE ACT, (D) PURSUANT TO AN
EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE ACT (IF AVAILABLE), OR (E) PURSUANT TO ANY OTHER EXEMPTION FROM THE
REGISTRATION REQUIREMENTS OF THE ACT, IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED
STATES OR ANY OTHER JURISDICTION.”

 

If required by the authorities of any state
in connection with the issuance of the Shares, the legend or legends required by such state authorities shall also be endorsed
on all such certificates.

 

    -24- 

     

    

 

Exhibit C

 

Lock-Up Agreement

 

Date: March [_], 2019

WallachBeth Capital, LLC

As Representative of the Underwriters

c/o WallachBeth Capital, LLC

100 Wall Street, Suite 6600

New York, NY
10006

 

Ladies and Gentlemen:

 

The undersigned understands that
you, as representative (the “Representative”), propose to enter into an Underwriting Agreement (the “Underwriting
Agreement”) with Guardion Health Sciences, Inc., a Delaware corporation (the “Company”), providing
for the public offering (the “Public Offering”) of shares of common stock, par value $0.001 per share, of the
Company (the “Shares”).

 

To induce the Representative to
continue their efforts in connection with the Public Offering, the undersigned hereby agrees that, without the prior written consent
of the Representative, the undersigned will not, during the period commencing on the date hereof and ending 180 days after the
date of the Underwriting Agreement (the “Lock-Up Period”), (1) offer, pledge, sell, contract to sell, grant,
lend, or otherwise transfer or dispose of, directly or indirectly, any Shares or any securities convertible into or exercisable
or exchangeable for Shares, whether now owned or hereafter acquired by the undersigned or with respect to which the undersigned
has or hereafter acquires the power of disposition (collectively, the “Lock-Up Securities”); (2) enter into
any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of
the Lock-Up Securities, whether any such transaction described in clause (1) or (2) above is to be settled by delivery of Lock-Up
Securities, in cash or otherwise; (3) make any demand for or exercise any right with respect to the registration of any Lock-Up
Securities; or (4) publicly disclose the intention to make any offer, sale, pledge or disposition, or to enter into any transaction,
swap, hedge or other arrangement relating to any Lock-Up Securities. Notwithstanding the foregoing, and subject to the conditions
below, the undersigned may transfer Lock-Up Securities without the prior written consent of the Representative in connection with
(a) transactions relating to Lock-Up Securities acquired in open market transactions after the completion of the Public Offering;
provided that no filing under Section 16(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”),
shall be required or shall be voluntarily made in connection with subsequent sales of Lock-Up Securities acquired in such open
market transactions; (b) transfers of Lock-Up Securities as a bona fide gift, by will or intestacy or to a family member
or trust for the benefit of the undersigned or a family member (for purposes of this lock-up agreement, “family member”
means any relationship by blood, marriage or adoption, not more remote than first cousin); (c) transfers of Lock-Up Securities
to a charity or educational institution; (d) if the undersigned, directly or indirectly, controls a corporation, partnership, limited
liability company or other business entity, any transfers of Lock-Up Securities to any shareholder, partner or member of, or owner
of similar equity interests in, the undersigned, as the case may be, (e) if required by the terms of a qualified domestic relations
order; provided that in the case of any transfer pursuant to the foregoing clauses (b), (c) or (d), (i) any such transfer
shall not involve a disposition for value, (ii) each transferee shall sign and deliver to the Representative a lock-up agreement
substantially in the form of this lock-up agreement and (iii) no filing under Section 16(a) of the Exchange Act shall be required
or shall be voluntarily made. The undersigned also agrees and consents to the entry of stop transfer instructions with the Company’s
transfer agent and registrar against the transfer of the undersigned’s Lock-Up Securities except in compliance with this
lock-up agreement.

 

    -25- 

     

    

 

The Representative agrees that,
if the undersigned is an executive officer or director of the Company, at least three (3) business days before the effective date
of any release or waiver of the foregoing restrictions in connection with a transfer of Lock-Up Securities, the Representative
will notify the Company of the impending release or waiver; and the Company has agreed in the Underwriting Agreement to announce
the impending release or waiver by press release through a major news service at least two (2) business days before the effective
date of the release or waiver. Any release or waiver granted by the Representative hereunder to any such officer or director shall
only be effective two (2) business days after the publication date of such press release. The provisions of this paragraph will
not apply if (a) the release or waiver is effected solely to permit a transfer of Lock-Up Securities not for consideration and
(b) the transferee has agreed in writing to be bound by the same terms described in this lock-up agreement to the extent and for
the duration that such terms remain in effect at the time of such transfer.

 

No provision in this agreement shall
be deemed to restrict or prohibit the exercise, exchange or conversion by the undersigned of any securities exercisable or exchangeable
for or convertible into Shares, as applicable; provided that the undersigned does not transfer the Shares acquired on such exercise,
exchange or conversion during the Lock-Up Period, unless otherwise permitted pursuant to the terms of this lock-up agreement. In
addition, no provision herein shall be deemed to restrict or prohibit the entry into or modification of a so-called “10b5-1”
plan at any time (other than the entry into or modification of such a plan in such a manner as to cause the sale of any Lock-Up
Securities within the Lock-Up Period).

 

The undersigned understands that
the Company and the Representative are relying upon this lock-up agreement in proceeding toward consummation of the Public Offering.
The undersigned further understands that this lock-up agreement is irrevocable and shall be binding upon the undersigned’s
heirs, legal representatives, successors and assigns.

 

The undersigned understands that,
if the Underwriting Agreement is not executed by March 31, 2019 or if the Underwriting Agreement (other than the provisions thereof
which survive termination) shall terminate or be terminated prior to payment for and delivery of the Shares to be sold thereunder,
then this lock-up agreement shall be void and of no further force or effect.

 

Whether or not the Public Offering actually
occurs depends on a number of factors, including market conditions. Any Public Offering will only be made pursuant to an Underwriting
Agreement, the terms of which are subject to negotiation between the Company and the Representative.

 

    -26- 

     

    

 

	 	Very truly yours,	 
	 	 	 
	 	 	 
	 	(Name)	 
	 	 	 
	 	 	 
	 	(Signature)	 

 

    -27- 

     

    

 

Exhibit D

 

Debenture

 

See attached.

 

    -28- 

     

    

 

Exhibit E

 

Warrant

 

See attached.

 

    -29-Exhibit 10.2

 

PROMISSORY NOTE

 

	$______________	 	March __, 2019

 

For value received,
GUARDION HEALTH SCIENCES, INC., a Delaware corporation, having an address at 15150 Avenue of Science, Suite 200, San Diego, California
92128 (the “Borrower”), hereby promises to pay to the order of _____________ (the “Lender”), at such address
or at such other place as the holder hereof may from time to time appoint in writing, in lawful money of the United States of America
in immediately available funds, the principal sum of $____________________ (the “Loan”). The Loan shall
be due and payable on or before September 30, 2019 (the “Maturity Date”).

 

This Note (the “Note”)
is being issued to evidence an unsecured loan to the Borrower for working capital purposes and operating expenses.

 

In consideration of
the granting of the Loan evidenced by this Note, the Borrower hereby agrees as follows:

 

1.       Interest
Rate. This is a fixed rate Note. Interest shall accrue at the rate of five percent (5%) per annum, and shall accrue on the
unpaid principal amount of this Note from the date hereof until all sums under this Note are paid in full. Interest shall be computed
on the basis of the actual number of days elapsed, as applicable, and divided by a 365/366 day factor.

 

2.       Payments.
For purposes hereof, the term Business Day shall mean any day that is not a Saturday, Sunday or a day on which banks are required
or permitted to be closed in the State of California. If payment to be made hereunder (principal, interest, expenses or otherwise)
becomes due and payable on a day other than a Business Day, the due date shall be extended to the next succeeding Business Day
and interest thereon shall be payable at the applicable interest rate provided for herein during such extension. Interest under
this Note will continue to accrue until payment is actually received or the Note. Payments may be applied in any order in the sole
discretion of Lender but, prior to the Maturity Date or an Event of Default, whichever should come first, payments shall be applied
first (in the following order) to past due interest, expenses, late charges and principal, then (in the following order) to current
interest, expenses, late charges and principal, and last to remaining principal.

 

3.       Form
of Payment. The principal amount and accrued interest of this Note shall be payable in cash to Lender on the Maturity Date,
unless this Note is converted into shares of Borrower’s common stock, par value $.0.001 per share (“Common Stock”)
pursuant to Section 4 below.

 

4.       Mandatory
Conversion. Concurrently with the consummation of a Qualified Offering, the principal amount and accrued interest of this Note
shall automatically be converted into shares of Common Stock at the Conversion Price. “Qualified Offering” shall mean
Borrower’s initial public offering of its Common Stock which offering definitively sets a price per share of the Common Stock
and enables Borrower to list its Common Stock on a national securities exchange. The Conversion Price shall equal the lower of
(a) 75% of the price per share of Common Stock of the Qualified Offering or (b) $2.30. Upon conversion, this Note shall be automatically
terminated without further action by any party hereto. Lender also acknowledges that any shares of Common Stock issuable to Lender
upon a Mandatory Conversion shall be subject to the lock-up provisions set forth in Section 3.11 of the Securities Purchase Agreement,
dated March 20, 2019, between the Borrower and Lender, pursuant to which this Note was issued.

 

     

     

    

 

5.       Warranties
and Representations. Borrower represents and warrants that: (a) it is duly organized, validly existing and in good standing
under the laws of the state of its organization; (b) the execution, issuance and delivery of this Note by the Borrower are within
its organizational powers and have been duly authorized, and the Note is valid, binding and enforceable in accordance with its
terms, and is not in violation of law or of the terms of the Borrower’s organizational documents and does not result in the
breach of or constitute a default under any indenture, agreement or undertaking to which the Borrower is a party or by which it
or its property may be bound or affected; (c) no authorization or approval or other action by, and no notice to or filing with,
any governmental authority or regulatory body is required for the due execution, delivery and performance by the Borrower of this
Note, except those as have been obtained; and (d) no Event of Default (as hereinafter defined) has occurred and no event has occurred
which with the giving of notice or the lapse of time or both would constitute an Event of Default.

 

6.       Event
of Default.

 

The occurrence of any
of the following events of default (“Event of Default”), unless timely cured as set forth herein, shall, at
the option of the Lender hereof, make all sums of principal and interest then remaining unpaid hereon and all other amounts payable
hereunder immediately due and payable, upon written notice, however, without presentment, demand or protest all of which hereby
are expressly waived, except as set forth below:

 

6.1       Failure
to Pay Principal or Interest. The Borrower fails to pay principal and interest or any other sum due under this Note as and
when the same becomes due and payable.

 

6.2       Breach
of Covenant. The Borrower breaches any material covenant or other material term or condition of this Note, in any material
respect and such breach, if subject to cure, continues for a period of twenty (20) Business Days after written notice to the Borrower
from the Lender.

 

6.3       Breach
of Representations and Warranties. Any material representation or warranty of the Borrower made herein, or in any agreement,
statement or certificate given in writing pursuant hereto or in connection therewith shall be false or misleading in any material
respect as of the date made and which has a material adverse effect on the Borrower, its assets, business operations or its ability
to pay this Note in full.

 

6.4       Receiver
or Trustee. The Borrower shall make an assignment for the benefit of creditors, or apply for or consent to the appointment
of a receiver or trustee for all or for a substantial part of its property or business; or such a receiver or trustee shall otherwise
be appointed.

 

    2

     

    

 

6.5       Bankruptcy.
Bankruptcy, insolvency, reorganization or liquidation proceedings or other proceedings or relief under any bankruptcy law or any
law, or the issuance of any notice in relation to such event, for the relief of debtors, shall be instituted by or against the
Borrower and if instituted against Borrower is not dismissed within sixty (60) days of initiation.

 

6.6       Insolvency.
Borrower admits its inability to pay its debts as they mature.

 

6.7       Cross
Default. A default by Borrower of a material term, covenant, warranty or undertaking of any other agreement to which Borrower
and the Lender are parties, or agreement made by Borrower in favor of holder, or the occurrence of any default under such other
agreement which is not cured after any required notice and/or cure period and which default may materially adversely affect such
Borrower’s ability to pay this Note or satisfy its liability under any other obligation to the Lender or the occurrence of
an “Event of Default” under any such other agreement.

 

7.       Suits
For Enforcement and Remedies.

 

The Lender may send
written notice of default to the Borrower at any time after the Maturity Date, or earlier upon an Event of Default. However, regardless
of whether the Lender sends written notice of default to Borrower, the Note shall bear interest at the Default Rate as set forth
above.

 

Upon an Event of Default,
the Lender may proceed to (i) protect and enforce Lender’s rights either by suit in equity or by action at law, or both,
whether for the specific performance of any covenant, condition or agreement contained in this Note or in any agreement or document
referred to herein or in aid of the exercise of any power granted in this Note or in any agreement or document referred to herein,
(ii) enforce the payment of this Note, or (iii) enforce any other legal or equitable right of the holder of this Note.
No right or remedy herein or in any other agreement or instrument conferred upon the Lender is intended to be exclusive of any
other right or remedy, and each and every such right or remedy shall be cumulative and shall be in addition to every other right
and remedy given hereunder or now or hereafter existing at law or in equity or by statute or otherwise.

 

8.       Unconditional
Obligation; Fees, Other.

 

8.1       The
obligations to make the payment provided for in this Note are absolute and unconditional and not subject to any defense, set-off,
counterclaim, rescission, recoupment or adjustment whatsoever.

 

8.2       If,
following the occurrence of an Event of Default, Lender shall seek to enforce the collection of any amount of principal of and/or
interest on this Note, there shall be immediately due and payable from Borrower, in addition to the then unpaid principal of, and
accrued unpaid interest on, this Note, all costs and expenses incurred by Lender in connection therewith, including, without limitation,
reasonable attorneys' fees and disbursements.

 

    3

     

    

 

8.3       This
Note may not be modified or discharged (other than by payment or exchange) except by a writing duly executed by Borrower and Lender.

 

8.4       Borrower
hereby expressly waives demand and presentment for payment, notice of nonpayment, notice of dishonor, protest, notice of protest,
bringing of suit, and diligence in taking any action to collect amounts called for hereunder, and shall be directly and primarily
liable for the payment of all sums owing and to be owing hereon, regardless of and without any notice, diligence, act or omission
with respect to the collection of any amount called for hereunder or in connection with any right, lien, interest or property at
any and all times which Lender had or is existing as security for any amount called for hereunder.

 

9.       Restriction
on Transfer.

 

This Note has been
acquired for investment, and this Note has not been registered under the securities laws of the United States of America or any
state thereof. Accordingly, no interest in this Note may be offered for sale, sold or transferred in the absence of registration
and qualification of this Note, under applicable federal and state securities laws or an opinion of counsel of Lender reasonably
satisfactory to the Lender that such registration and qualification are not required.

 

10.       Miscellaneous.

 

10.1       Modifications;
Waivers. No modification or waiver of any provision of this Note shall be effective unless such modification or waiver shall
be in writing and signed by Lender, and the same shall then be effective only for the period and on the conditions and for the
specific instances specified in such writing. No failure or delay by the Lender in exercising any right, power or privilege hereunder
shall operate as a waiver thereof; nor shall any single or partial exercise thereof preclude any other or further exercise thereof
or the exercise of any rights, power or privilege.

 

10.2       Notices.
All notices, demands, requests, consents, approvals, and other communications required or permitted hereunder shall be in writing
and, unless otherwise specified herein, shall be: (i) personally served; (ii) deposited in the mail, registered or certified, return
receipt requested, postage prepaid; (iii) delivered by reputable air courier service with charges prepaid; or (iv) transmitted
by hand delivery, telegram, or confirmed facsimile, addressed as set forth below or to such other address as such party shall have
specified most recently by written notice. Any notice or other communication required or permitted to be given hereunder shall
be deemed effective: (a) upon hand delivery, e-mail, or delivery by facsimile, with accurate confirmation generated by the transmitting
facsimile machine, at the address or number designated below (if delivered on a business day during normal business hours where
such notice is to be received), or the first business day following such delivery (if delivered other than on a business day during
normal business hours where such notice is to be received); or (b) on the second business day following the date of mailing by
express courier service, fully prepaid, addressed to such address, or upon actual receipt of such mailing, whichever shall first
occur. The addresses for such communications shall be: (x) if to the Borrower to the address set forth above in the Preamble; David
Sunkin, Esq., Sheppard, Mullin, Richter & Hampton LLP, 333 South Hope Street, 43rdFloor, Los Angeles, California
90071 and (y) if to the Lender, to the address set forth above in the Preamble.

 

    4

     

    

 

 

10.3       Amendment
Provision. The term “Note” and all references thereto, as used throughout this instrument, shall mean this
instrument as originally executed, or if later amended or supplemented, then as so amended or supplemented.

 

10.4       Non-Assignability.
The Borrower may not delegate its obligations under this Note and such attempted delegations shall be null and void. The Lender
may not assign, pledge or otherwise transfer this Note without the prior written consent of the Borrower which consent shall not
be unreasonably withheld. This Note inures to the benefit of Lender, its successors and its assignee of this Note and binds the
Borrower, and its successors and assigns, and the terms “Lender” and “the Borrower” whenever occurring
herein shall be deemed and construed to include such respective successors and assigns. Any assignment or transfer made in violation
of this Section 12.4 or Section 11 hereunder shall be void ab initio.

 

10.5       Governing
Law. This Note shall be governed by and construed in accordance with the laws of the State of California, without regard to
conflicts of laws principles that would result in the application of the substantive laws of another jurisdiction. Any action brought
by either party against the other concerning the transactions contemplated by this Agreement shall be brought only in the state
or federal courts of California. Both parties and the individual signing this Note on behalf of the Borrower agrees to submit to
the personal jurisdiction of such courts. The parties to this Agreement hereby irrevocably waive any objection to jurisdiction
and venue in any action instituted hereunder and shall not assert any defense based on lack of jurisdiction or venue or based upon
forum non conveniens. The parties executing this Agreement and the other agreements referred to herein or delivered in connection
herewith on behalf of the Borrower agrees to submit to the jurisdiction of such courts and hereby irrevocably waive trial by jury.
The prevailing party shall be entitled to recover from the other party its reasonable attorneys’ fees, costs and expenses.
In the event that any provision of this Note is invalid or unenforceable under any applicable statute or rule of law, then such
provision shall be deemed inoperative to the extent that it may conflict therewith and shall be deemed modified to conform with
such statute or rule of law. Any such provision which may prove invalid or unenforceable under any law shall not affect the validity
or unenforceability of any other provision of this Note. Nothing contained herein shall be deemed or operate to preclude the Lender
from bringing suit or taking other legal action against the Borrower in any other jurisdiction where the Borrower hold assets to
collect on the Borrower’s obligations to the Lender, to realize on any collateral or any other security for such obligations,
or to enforce a judgment in another court in favor of the Lender.

 

    5

     

    

 

10.6       WAIVER.
EACH PARTY HERETO HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN
ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY
(WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY). EACH PARTY HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY
OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO
ENFORCE THE FOREGOING WAIVER AND (B) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER INTO THIS AGREEMENT
BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 10.6.

 

10.7       Successors
and Assigns. This Note shall be binding upon and inure to the benefit of the Borrower, the Lender, all future holders of this
Note and their respective successors and assigns, except that Borrower may not assign, delegate or transfer any of its rights or
obligations under this Note (other than in connection with a dissolution or a transaction involving a merger or consolidation,
in each case otherwise permitted by this Agreement) without the prior written consent of the Lender.

 

10.8       Maximum
Payments. Nothing contained herein shall be deemed to establish or require the payment of a rate of interest or other charges
in excess of the maximum permitted by applicable law. In the event that the rate of interest required to be paid or other charges
hereunder exceed the maximum permitted by such law, any payments in excess of such maximum shall be credited against amounts owed
by the Borrower to the Lender and thus refunded to the Borrower.

 

12.9       
Construction. Each party acknowledges that its legal counsel participated, or was afforded the opportunity to participate,
in the preparation of this Note and, therefore, stipulates that the rule of construction that ambiguities are to be resolved against
the drafting party shall not be applied in the interpretation of this Note to favor any party against the other.

 

12.10       Counsel.
Borrower acknowledges that it has been advised to consult with an attorney with respect to negotiations of and decisions to enter
into the Loan prior to its execution.

 

12.11       Information.
Borrower shall furnish to the Lender all information relevant to the Borrower’s obligations under this Agreement and all
material or information reasonably requested by the Lender.

 

[SIGNATURE PAGE TO FOLLOW]

 

    6

     

    

 

IN WITNESS WHEREOF,
Borrower has caused this Promissory Note to be signed in its name by an authorized officer as of the date first above written.

 

	 	GUARDION HEALTH SCIENCES, INC.
	 	 	 	 
	 	By:	 	 
	 	 	Name:	Michael Favish
	 	 	Title:	Chief Executive Officer

 

    7

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