Document:

EXHIBIT 10.16

                            SECOND AMENDMENT TO LEASE

     THIS AGREEMENT,  made as of and entered as of this 6th day of June 1998, by
and between  Newmarket  Partners I, Ltd., a Georgia Limited  Partnership,  whose
general  partners  are  Laing  Properties,  Inc.  and Laing  Management  Company
(hereinafter  called  "Landlord")  and  Cryolife,  Inc.,  a Florida  corporation
(hereinafter called "Tenant").

                                WITNESSETH THAT:

     WHEREAS,  Landlord and Tenant entered into a certain Lease  Agreement dated
July 23, 1993, as amended June 9, 1994 (collectively,  hereinafter  "Lease") for
Suite 124,  Building 5,  (hereinafter  "Premises")  at 2121  Newmarket  Parkway,
Marietta, Cobb County, Georgia 30067.

     WHEREAS,  Landlord and Tenant  desire to amend the Lease in order to modify
some of the terms and conditions of the Lease; and

     WHEREAS, Tenant desires to extend the Term of the Lease an additional three
(3)  years for the  period of  November  16,  1998  through  November  15,  2001
(hereinafter "Renewal Term").

     NOW, THEREFORE in consideration of the mutual agreements of the undersigned
and  other  good and  valuable  consideration,  this  Lease is  hereby  amended,
effective November 16, 1998, as follows:

47.  BROKER DISCLOSURE

     Pursuant  to Georgia  Real Estate  Commission  Regulation  520-1-08,  Laing
Marketing  Company  makes  the  following  disclosures   concerning  this  Lease
transaction:

     a)   In this transaction,  Laing Marketing Company represents  Landlord and
          not Tenant.

     b)   In this  transaction,  Richard Bowers & Company  represents Tenant and
          not Landlord.

     c)   In this transaction, both Laing Marketing Company and Richard Bowers &
          Company shall receive their compensation from Landlord exclusively.

     Both  Tenant  and  Landlord  acknowledge,  agree  with and  consent  to the
representation and compensation disclosed above.

48.  ENVIRONMENTAL MATTERS

     Tenant will be subject to the provisions contained in Exhibit "E" entitled,
"Environmental  Matters',  attached  hereto  and by this  reference  made a part
hereof.

49.  TERM

     Paragraph 2, Term, of the Lease shall be amended to read:

     To have and to hold the same  for the  term to  commence  on the  sixteenth
     (16th)  day of  November  1998 and  ending on the  fifteenth  (15th) day of
     November  2001,  at  midnight,  unless  sooner  terminated  as  hereinafter
     provided.

50.  RENTAL

     Paragraph 3, Rental, of the Lease shall be amended to read:

     The Tenant agrees to pay to the Landlord  promptly on the first day of each
     month in advance, during the term of this Lease, a monthly rental of:

       November 16, 1998 through November 15, 1999 @ $7,952.46 per month
       November 16, 1999 through November 15, 2000 @ $8,270.56 per month
       November 16, 2000 through November 15, 2001 @ $8,601.38 per month

<PAGE>

Page 2 of Second Amendment to Lease by and between Newmarket  Partners I Ltd., a
Georgia Limited Partnership,  whose general partners are Laing Properties,  Inc.
and Laing  Management  Company and Cryolife Inc., a Florida  corporation,  dated
June 6, 1998.

          Payments  received after the tenth day of the month may be assessed an
          additional five percent (5%) charge as agreed  liquidated  damages due
          Landlord. Acceptance by Landlord of a rental payment in an amount less
          than that which is  currently  due shall in no way  affect  Landlord's
          rights under this Lease and in no way be an accord and satisfaction.

51.  TENANT IMPROVEMENTS

     The Premises will be leased "as-is" during the Renewal Term and any and all
     improvements shall be at Tenant's sole cost and expense.

     Except as herein  amended,  all terms  and  conditions  of the Lease  shall
remain in full force and effect.

     IN  WITNESS  WHEREOF,  the  parties  hereunto  have  executed  this  Second
Amendment to Lease as of the day and year first above written.

Signed, sealed and delivered     LANDLORD: Newmarket Partners I, Ltd. a
in the presence of:                        Georgia Limited Partnership,
                                           whose general partners are Laing
                                           Properties, Inc. and Laing
                                           Management Company

                                  BY:      Laing Properties, Inc.
                                           Managing General Partner

/s/  Patricia L. Pendley          BY:      /s/  James A. Gillespie
--------------------------                 -------------------------------------
Witness                                    James A. Gillespie

                                  TITLE:   Executive Vice President

/s/  Julie J. Waller              ATTEST:  /s/  Robert R. Stubbs
--------------------------                 -------------------------------------
Notary Public                              Robert R. Stubbs

                                  TITLE:   Vice President & Secretary
                                           -------------------------------------
                                           (CORPORATE SEAL)

Signed, sealed and delivered      TENANT:  Cryolife, Inc., a Florida Corporation
in the presence of:

/s/  Felicia E. Trott             BY:      /s/  Albert E. Heacox
--------------------------                 -------------------------------------
Witness
                                  TITLE:   V.P. Laboratory Operations
                                           -------------------------------------

/s/  Suzanne K. Gabbert           ATTEST:  /s/ Suzanne K. Gabbert
--------------------------                 -------------------------------------
Notary Public
                                  TITLE:   Assistant Corporate Secretary
                                           -------------------------------------
Notary Public, Cobb County, Georgia                  (CORPORATE SEAL)
My Commission Expires:
September 13, 2000

                                       2
<PAGE>

                                   EXHIBIT "E"
                              ENVIRONMENTAL MATTERS

A.   Tenant   covenants  that  it  will  not  cause  or  permit,   knowingly  or
     unknowingly,  any Hazardous  Wastes (as hereinafter  defined) to be brought
     upon, disposed on or stored in or on the Premises or any Hazardous Material
     (as  hereinafter  defined) to be released  in, on or about the Premises and
     that it will comply with any and all applicable  laws,  ordinances,  rules,
     regulations  and  requirements  respecting the presence,  use or release of
     Hazardous Materials in, on or about the Premises.

B.   Tenant covenants that it will immediately notify Landlord,  in writing,  of
     any existing,  pending or threatened (i) investigation,  inquiry,  claim or
     action by any governmental  authority in connection with any  Environmental
     Laws (as hereinafter  defined);  (ii) third party claims;  (iii) regulatory
     actions; and/or (iv) contamination of the Premises.

C.   Tenant shall, at Tenant's expense, investigate,  monitor, remediate, and/or
     clean up any Hazardous  Material,  Hazardous Waste, or other  environmental
     condition on, about, or under the Premises required as a result of Tenant's
     use or occupancy of the Premises.

D.   Tenant  covenants  that it shall keep the Premises free of any lien imposed
     pursuant to any Environmental Laws.

E.   Tenant shall indemnify,  defend and hold Landlord harmless from and against
     any and all claims, judgments,  damages, penalties, fines, costs (including
     without limitation, attorney's fees and court costs), liabilities or losses
     (collectively,  the "Tenant  Indemnified  Claims")  resulting  from (i) the
     presence  of  Hazardous  Wastes in or about the  Premises or the release of
     Hazardous  Materials  in, on or a bout the Premises on or after the date of
     this Lease, and (ii) any Hazardous Waste placed or any Hazardous  Materials
     released  elsewhere  in  Newmarket  Business  Park by Tenant,  its  agents,
     invitees, employees and contractors.

F.   The  provisions  of this  Exhibit  "E"  shall  survive  the  expiration  or
     termination of this Lease.

G.   For purposes of this Lease,  the term Hazardous  Waste has the same meaning
     as the term is defined in the Resource  Conservation  and Recovery  Act, as
     amended, 42 U.S.C.ss.6901 et. seq. ("RCRA").

H.   For the purposes of this Lease, the term Hazardous Material,  is defined to
     include  those  matters  described  in  the   Comprehensive   Environmental
     Response,  Compensation and Liability Act, as amended, 42 U.S.C.ss.9601 et.
     seq.  ("CERCLA").  As used herein the term Hazardous  Materials  shall also
     mean  (i)   asbestos,   or  any   substance   containing   asbestos;   (ii)
     polychlorinated  biphenyls;  (iii) lead; (iv) radon;  (v) pesticides;  (vi)
     petroleum  or  any  other  substance  containing  hydrocarbons;  (vii)  any
     substance which,  when on the Premises,  is prohibited by any Environmental
     Laws; and (viii) any other  substance,  material or waste which, (x) by any
     Environmental  Laws  requires  special  handling  or  notification  of  any
     governmental authority in its collection,  storage,  treatment, or disposal
     or (y) is defined or classified as hazardous,  dangerous or toxic  pursuant
     to any legal requirement.

I.   For  purposes of this  Lease,  Environmental  Laws shall mean:  any and all
     federal, state and local laws, statutes,  codes,  ordinances,  regulations,
     rules or other  requirements  relating to human  health or safety or to the
     environment including, but not limited to, those applicable to the storage,
     treatment,  disposal,  handling  and  release  of any  Hazardous  Waste  or
     Hazardous Materials, all as amended or modified from time to time.

                                       -i-

1545087EXHIBIT 10.17

                            THIRD AMENDMENT OF LEASE

     THIS THIRD AMENDMENT OF LEASE ("Third Amendment") is made on August 3, 2001
between  TRIZECHAHN  CENTERS INC., a California  corporation,  d/b/a "TrizecHahn
Newmarket 1 to 8 Management"  ("Landlord"),  whose address is 100 Colony Square,
Suite 600, 1175 Peachtree Street, N.E., Atlanta, GA 30361 and CRYOLIFE,  INC., a
Florida corporation ("Tenant").

                                    RECITALS

     This Third Amendment is based upon the following recitals:

     A.  Newmarket  Partners I,  Limited  ("Newmarket"),  as landlord and Tenant
entered into a Lease dated July 23, 1993 ("Lease"),  for the premises  measuring
11,227  rentable  square feet and known as Suite 124  located at 2121  Newmarket
Parkway, Marietta, GA 30067 ("Premises").

     B. Newmarket and Tenant amended the Lease by First Amendment to Lease dated
June 9,  1994 and  Second  Amendment  to Lease  dated  June 6, 1998  (Lease  and
Amendment(s) collectively, "Lease as amended").

     C.  Landlord is successor in interest to  Newmarket's  interest as landlord
under the Lease as amended.

     D. The Premises  size  currently  measures  approximately  11,227  rentable
square feet and includes Suite 124 of the Building.

     E.  Landlord  and Tenant  desire to  further  amend the Lease as amended to
extend the term and otherwise amend the Lease as
amended accordingly.

     THEREFORE,  in consideration of the mutual covenants and agreements  stated
in the  Lease as  amended  and  below,  and for other  sufficient  consideration
received and acknowledged by each party,  Landlord and Tenant agree to amend the
Lease as amended as follows:

     1. RECITALS. All recitals are fully incorporated.

     2. ADDRESS - NOTICES.  Landlord's address for notices as set forth in Lease
as amended shall be deleted and the following substituted therefor:

        TRIZECHAHNCENTERS  INC.
        c/o TrizecHahn Office Properties,  Inc.
        100 Colony  Square,   Suite  600
        1175 Peachtree Street, N.E.
        Atlanta, GA 30361
        Attention: David D. Canaday, Vice President

 1545085v1
<PAGE>

        with a copy to:

        TRIZECHAHN CENTERS INC.
        c/o TrizecHahn Office Properties, Inc.
        100 Colony Square, Suite 600
        1175 Peachtree Street, N.E.
        Atlanta, GA 30361
        Attention: Lease Administrator

        and if notice of default, a copy to:

        TRIZECHAHN CENTERS INC.
        c/o TrizecHahn Office Properties, Inc.
        100 Colony Square, Suite 600
        1175 Peachtree Street, N.E.
        Atlanta, GA 30361
        Attention: Regional Counsel

     3.  EXTENSION  OF LEASE  TERM.  The Lease  Term for the  Premises  shall be
extended for  approximately  thirteen  and  one-half  (13 1/2) months,  to begin
November 16, 2001 and expire on December 31, 2002 ("2nd Extension Term").

     4. RENTAL,  COMMON AREA MAINTENACE  EXPENSES,  TAX AND INSURANCE ESCALATION
EXPENSES.Effective during 2nd Extension Term, Tenant's obligation to pay Rental,
Common Area Maintenance Expenses and Tax and Insurance Escalation Expenses shall
be as follows with respect to the Premises:

          A. RENTAL.  Effective during the 2nd Extension Term,  Tenant shall pay
Landlord  monthly rental in advance on the first day of each month in the amount
of $9,355.83; and

          B. COMMON AREA MAINTENACE  EXPENSES.  Tenant shall reimburse  Landlord
for the cost of Common Area Maintenance Expenses (as described in Paragraph 4 of
the Lease, "CAM") which shall be $0.80 per rentable square foot and subject to a
4% annual increase each calendar year; and

          C. TAX AND INSURANCE  ESCALATIONS  EXPENSES. In addition to Rental and
CAM,  Tenant shall continue to be responsible  for tax and insurance  escalation
expenses with respect to the entire  Premises in  accordance  with the terms and
conditions  of  Paragraph 5 of the Lease;  however the base year with respect to
determining tax and insurance  escalation expenses for the Premises shall be the
calendar year ending December 31, 2002.

     5. DELIVERY OF AND IMPROVEMENTS TO THE PREMISES. Landlord shall provide and
Tenant  shall accept the  Premises in "as-is"  condition.  No promises to alter,
remodel or improve the  Premises or Building and no  representations  concerning
the  condition of the Premises or Building  have been made by Landlord to Tenant

<PAGE>

other than as may be expressly stated in the Lease as amended.

     6.  HOLDOVER.  Tenant  understands  that it does not have the right to hold
over at any time and  Landlord  may  exercise  any and all remedies at law or in
equity to recover possession of the Premises, as well as any damages incurred by
Landlord,  due to Tenant's failure to vacate the Premises and deliver possession
to Landlord as required by this Lease. If Tenant holds over after the expiration
of the 2nd Extension Term with Landlord's prior written consent,  Tenant will be
deemed to be a tenant  from  month to month,  at a monthly  Rental,  payable  in
advance, equal to 150% of the monthly Rental payable during the last year of the
2nd  Extension  Term,  and  Tenant  will be  bound  by all of the  other  terms,
covenants  and  agreements  of the Lease as  amended  as the same may apply to a
month-to-month  tenancy.  If Tenant holds over after the  expiration  of the 2nd
Extension Term without Landlord's prior written consent, Tenant will be deemed a
tenant at sufferance,  at a daily Rental,  payable in advance,  equal to 200% of
the Rental per day payable  during the 2nd  Extension  Term,  and Tenant will be
bound by all of the  other  terms,  covenants  and  agreements  of the  Lease as
amended as the same may apply to a tenancy at sufferance.

     7.  BROKERS.  Landlord and Tenant  represent  and warrant that no broker or
agent negotiated or was  instrumental in negotiating or consummating  this Third
Amendment  except  TrizecHahn  Colony Square GP LLC and Richard Bowers & Company
("Brokers"). Neither party knows of any other real estate broker or agent who is
or might be entitled to a commission or  compensation  in  connection  with this
Third  Amendment.   Pursuant  to  Georgia  Real  Estate  Commission   Regulation
520-1-108,  TrizecHahn  Colony  Square GP LLC  hereby  discloses  the  following
concerning  this  lease  transaction:   (1)  TrizecHahn  Colony  Square  GP  LLC
represents  Landlord  and not Tenant;  (2) Richard  Bowers & Company  represents
Tenant  and not  Landlord;  and (3) both  TrizecHahn  Colony  Square  GP LLC and
Richard Bowers & Company shall receive their compensation from Landlord.  Tenant
and Landlord will  indemnify and hold each other  harmless from all damages paid
or incurred by the other resulting from any claims asserted against either party
by brokers or agents claiming through the other party.

     8.  CONFLICTING  PROVISIONS.  If any  provisions  of this  Third  Amendment
conflict with any of those of the Lease as amended,  then the provisions of this
Third Amendment shall govern.

     9. REMAINING LEASE  PROVISIONS.  Except as stated in this Third  Amendment,
all other viable and applicable  provisions of the Lease as amended shall remain
unchanged and continue in full force and effect throughout the Lease Term.

     10.  BINDING  EFFECT.  Landlord and Tenant  ratify and confirm the Lease as
amended and agree that this Third  Amendment shall bind and inure to the benefit
of the parties, and their respective successors,  assigns and representatives as
of the date first stated.

                    -signatures appear on the following page-

<PAGE>

     AFFIRMING  THE ABOVE,  the parties have  executed  this THIRD  AMENDMENT OF
LEASE on the date first stated.

WITNESSES:                         LANDLORD:
                                   TRIZECHAHN CENTERS INC., a
                                   California corporation

  /s/   Mardi Taft                 BY:  /s/   Robert R. Stubbs
--------------------------             --------------------------------
                                           Robert R. Stubbs
                                           Assistant Secretary

  /s/  Carmel Malfeo               BY:  /s/   Antonio A. Bismonte
--------------------------             --------------------------------
                                           Antonio A. Bismonte
                                           Vice President

                                   TENANT:
                                   CRYOLIFE, INC., a Florida
                                   corporation

                                   By:  /s/   Albert E. Heacox
                                       --------------------------------
                                   ITS:  Sr. V.P. Laboratory Operations
                                        -------------------------------

1545085

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