Document:

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                                                                 EXHIBIT 10.28.2

                            THIRD AMENDMENT TO LEASE

      This Third Amendment to Lease ("Third Amendment") is made as of December
17, 2004, by and between ARE-ONE INNOVATION DRIVE, LLC, a Delaware limited
liability company ("Landlord"), and VIACELL, INC., a Delaware corporation
("Tenant").

                                    RECITALS

      A. Landlord is the landlord and Tenant is the tenant under a Lease dated
as of February 24, 2000, between Landlord and Tenant's predecessor by name
change t.Breeders, Inc., as amended by that certain First Amendment to Lease
dated as of May 23, 2001, between Landlord and tenant and as further amended by
that certain Second Amendment to Lease dated as of April 14, 2002, between
Landlord and Tenant (as amended, the "Lease"), under which tenant leases
approximately 18,501 rentable square feet of space in the building commonly
known as One Innovation Drive, Worcester, Massachusetts, and as more
particularly described in the Lease. Capitalized terms used herein without
definition shall have the meanings defined for such terms in he Lease.

      B. The Term of the Lease for the Premises is scheduled to terminate on
February 20, 2005.

      C. Subject to the terms and conditions set forth herein, Landlord and
Tenant desire to, among other things, amend the Lease to extend the term of the
Lease for a portion of the Premises.

                                    AGREEMENT

      NOW, THEREFORE, in consideration of the foregoing, in further
consideration of the mutual promises made herein, and for other good and
valuable consideration, receipt of which is acknowledged, Landlord and tenant
hereby agree as follows:

      1. Term. The Term of the Lease is extended from its scheduled termination
date of February 28, 2005, until May 31, 2005. Thereafter, the Term shall
continue on a month-to-month basis until such time as either party elects to
terminate this Lease by providing at least 30 days prior written notice of such
election to the other party. For example, if either party provides such notice
to the other party on May 10, 2005, the Lease shall terminate on June 9, 2005.

      2. Premises. Tenant shall, on or before February 28, 2005, surrender the
portion of the Premises consisting of approximately 7,916 rentable square feet
and more particularly described on Exhibit B attached hereto (the "Surrender
Space"). Commencing on March 1, 2005, the defined term Premises in the Lease
shall be amended to read as follows:

      Premises: That portion of the Project, containing approximately 10,585
      rentable square feet, as determined by Landlord, as shown on Exhibit A
      attached hereto.

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      3. Base Rent and Operating Expenses. Commencing on March 1, 2005, Tenant
shall pay Base Rent for the Premises in the amount of $26,303.25 per month and
Tenant's Share of Operating Expenses shall be 9.19%.

      4. Surrender. Tenant agrees to voluntarily surrender the Surrender Space
on or before February 28, 2005, in compliance with all of the terms and
conditions of the Lease with respect to the condition in which space is required
under the Lease to be surrendered to Landlord at the expiration or earlier
termination of the term of the Lease. Thereafter, Tenant shall have no further
right to occupy or use the Surrender Space.

      5. Miscellaneous.

            (a) This Third Amendment is the entire agreement between the parties
      with respect to the subject matter hereof and supersedes all prior and
      contemporaneous oral and written agreements and discussions with respect
      to the matters addressed herein. This Third Amendment may be amended only
      by an agreement in writing, signed by the parties hereto.

            (b) This Third Amendment is binding upon and shall inure to the
      benefit of the parties hereto, their respective agents, employees,
      representatives, officers, directors, divisions, subsidiaries, affiliates,
      assigns, heirs, successors in interest and shareholders.

            (c) This Third Amendment may be executed in any number of
      counterparts, each of which shall be deemed an original, but all of which
      when taken together shall constitute one and the same instrument. The
      signature page of any counterpart may be detached therefrom without
      impairing the legal effect of the signature(s) thereon provided such
      signature page is attached to any other counterpart identical thereto
      except having additional signature pages executed by other parties to this
      Third Amendment attached thereto.

            (d) Landlord and Tenant each represent and warrant that it has not
      dealt with any broker, agent or other person (collectively, "Broker") in
      connection with this transaction, and that no Broker brought about this
      transaction. Landlord and Tenant each hereby agree to indemnify and hold
      the other harmless from and against any claims by any Broker claiming a
      commission or other form of compensation by virtue of having dealt with
      Tenant or Landlord, as applicable, with regard to this leasing
      transaction.

            (e) Except as amended and/or modified by this Third Amendment, the
      Lease is hereby ratified and confirmed and all other terms of the Lease
      shall remain in full force and effect, unaltered and unchanged by this
      Third Amendment. In the event of any conflict between the provisions of
      this Third Amendment and the provisions of the Lease, the provisions of
      this Third Amendment shall prevail. Whether or not specifically amended by
      this Third Amendment, all of the terms and provisions of the Lease are
      hereby amended to the extent necessary to give effect to the purpose and
      intent of this Third Amendment.

                                      -2-
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       IN WITNESS WHEREOF, this Third Amendment to Lease has been duly executed
and delivered by landlord and Tenant as of the date first above written.

                                     TENANT:

                                     VIACELL, INC.
                                     a Delaware corporation

                                    By:   /s/ Mary Thistle
                                       --------------------------
                                     Its:  VP General Manager
                                         ------------------------

                                     LANDLORD:

                                     ARE-ONE INNOVATION DRIVE, LLC,
                                     a Delaware limited liability company

                                     By:  AREE-HOLDINGS, L.P.,
                                          a Delaware limited partnership,
                                          managing member

                                          By:   ARE-GP HOLDINGS QRS CORP.,
                                                a Delaware corporation,
                                                general partner

                                                By:   /s/ Jennifer Pappas
                                                    ----------------------------
                                                Its:  V.P. & Assistant Secretary
                                                    ----------------------------

                                      -3-
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                                    EXHIBIT A

                           Description of the Premises

                                   (Attached)

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                                    EXHIBIT B

                       Description of the Surrender Space

                                   (Attached)<PAGE>
                                                                   EXHIBIT 10.35

                                 [VIACELL LOGO]

October 10, 2004

Mary Thistle
9 Longview Drive
Chelmsford, MA 01824

Dear Mary,

On behalf of ViaCell, Inc. (the "Company"), I am pleased to extend our offer for
the new role of General Manager, ViaCell Reproductive Health. You continue to
deliver outstanding results in your work with ViaCell and you have made an
outstanding impression during your interim leadership of VRH. I am confident you
will succeed in this new role. Information about the details of our offer are
summarized below.

POSITION         General Manager, ViaCell Reproductive Health, reporting to Marc
                 Beer, Chief Executive Officer. This position is a key factor in
                 ViaCell's continued success, and I am confident that it will be
                 an exciting opportunity for you as well.

                 In this role, your duties will include the following:
                        -     Full P&L responsibility for ViaCell Reproductive
                              Health and its commercial business
                        -     Launch of our new Viacyte product
                        -     Successful development and execution of strategic
                              plans, staff and process to continue execution
                              against commercial goals and future growth in the
                              business.

COMPENSATION     The base salary for this position will be $220,000.00 per year
                 payable in bi-weekly installments of $8461.54. This salary will
                 be effective October 13, 2004, upon Board approval.

                 In addition, you will be eligible to participate in the
                 Management Bonus Plan at an annual target of 25% of base
                 salary, which is initially $55,000 at your new pay rate. This
                 bonus is payable annually based on agreed to company and
                 individual performance objectives. Your bonus payout is
                 determined based on achievement of both corporate and
                 individual goals.

STOCK OPTIONS    As an incentive for you to participate in the Company's future
                 growth, you will receive, subject to approval by our Board of
                 Directors, options to purchase an additional 50,000 shares of
                 our Common Stock (the "Options"). The Options will be incentive
                 stock options ("ISO's") to the extent allowable under the
                 Internal Revenue Code. The exercise price of the Options equals
                 the fair market value of our Common Stock as determined by the
                 Board of Directors on your effective date; your fair market
                 value price is $5.00 per share. The Options will vest quarterly
                 over four years beginning on the last day of the first quarter
                 after your effective date. The

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M. Thistle GM Offer
October 10, 2004
Page 2

                 Options will be granted under the Company's 1998 Equity
                 Incentive Plan pursuant to an ISO certificate or nonstatutory
                 stock option ("NSO") certificate, as appropriate, shall have a
                 term of ten years and contain such additional terms as shall
                 be determined by the Board of Directors of the Company or the
                 Compensation Committee thereof.

ADDITIONAL       ViaCell will provide for six months' severance pay in the event
EMPLOYMENT       of involuntary termination without cause or voluntary
TERMS            termination for good reason. If the Company shall terminate
                 your employment without "cause" or if you terminate your
                 employment for "good reason," then ViaCell will continue paying
                 your base salary and medical and dental benefit contributions
                 for a period of six months in accordance with its regular
                 payroll practices at such time. If the Company terminates your
                 employment with "cause," then ViaCell will continue paying your
                 base salary for a period of thirty days and all options will
                 cease to continue vesting as of the date of termination. The
                 term "cause" as used here means (i) your continued failure to
                 substantially perform your duties provided you are reasonably
                 notified of such failure and given reasonable time to correct
                 such failure, (ii) any misappropriation of funds, properties or
                 assets of the Company by you, (iii) any damage or destruction
                 of any property or assets of the Company caused by you, whether
                 resulting from your willful actions or willful omissions or
                 gross negligence; (iv) your being convicted of a felony; or (v)
                 any material breach of your employment obligations or of the
                 Intellectual Property and Confidential Information Agreement.
                 The term "good reason" as used here means any action by the
                 Company without your prior consent which results in (i) any
                 material diminution in your title, position, duties,
                 responsibilities or authority; or (ii) any breach by the
                 Company of any material provision contained herein.

I am very excited about the future of ViaCell and believe that the opportunities
presented for our continued commercial success will allow you significant
personal and professional growth. I am more confident than ever of our success
with you in this key role. I look forward to working closely with you over the
coming years ahead!

Sincerely,

/s/ MARC BEER

Marc Beer
Chief Executive Officer

/s/  MARY THISTLE
------------------------------      --------------------------------------
Signature                           Date

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