Document:

Common Stock Purchase Agreement

 Exhibit 10.7G 
 JULY 6, 2007 
 TERCICA, INC. 
 and 
 GENENTECH, INC. 
  

 COMMON STOCK PURCHASE AGREEMENT

  

 CONTENTS 
  

					
	 	 	 	  	PAGE
	 CLAUSE
	 		  	
			
	 ARTICLE 1
	 	DEFINITIONS	  	1
			
	 ARTICLE 2
	 	PURCHASE AND SALE OF SHARES	  	8
			
	 ARTICLE 3
	 	REPRESENTATIONS AND WARRANTIES OF TERCICA	  	12
			
	 ARTICLE 4
	 	REPRESENTATIONS AND WARRANTIES OF GENENTECH	  	18
			
	 ARTICLE 5
	 	COVENANTS	  	20
			
	 ARTICLE 6
	 	CONDITIONS TO FIRST CLOSING	  	21
			
	 ARTICLE 7
	 	CONDITIONS TO SECOND OPTION CLOSING	  	24
			
	 ARTICLE 8
	 	CONDITIONS TO MILESTONE CLOSING	  	25
			
	 ARTICLE 9
	 	TERMINATION	  	27
			
	 ARTICLE 10
	 	MISCELLANEOUS	  	28

 SCHEDULES 
 Disclosure Schedule 
 EXHIBITS 
 Exhibit A
– Second Amended and Restated Investors’ Rights Agreement 

 THIS COMMON STOCK PURCHASE AGREEMENT (the Agreement) is made as of July 6, 2007,

 BETWEEN: 
  

	(1)	TERCICA, INC., a corporation organized under the laws of the State of Delaware, with its principal offices at 2000 Sierra Point Parkway, Suite 400, Brisbane, California 94005
(Tercica); and 

  

	(2)	GENENTECH, INC., a corporation organized under the laws of the State of Delaware, with its principal offices at 1 DNA Way, South San Francisco, California 94080
(Genentech). 

 IN CONSIDERATION of the mutual covenants contained in this Agreement, Tercica and Genentech
agree as follows: 
 ARTICLE 1 
 DEFINITIONS 
 1.1 In this Agreement, the following words and expressions have the following meaning: 
  

	(a)	Affiliate of a Party means any corporation or other business entity that, directly or indirectly, through one or more intermediaries, controls, is controlled by, or is
under common control with such Party. For purposes of this definition, the term “control” (including, the correlative meanings, “controlled by” and “under common control with”) means (A) the direct or indirect
ownership of fifty percent (50%) or more of the stock having the right to vote for directors thereof (or general partnership interests) or (B) the ability to otherwise control the decisions of the board of directors or equivalent governing
body thereof. In the case of Genentech, for purposes of this Agreement, the term Affiliate shall not include Roche Holding Ltd (for purposes of this definition, Roche) and its successors, or any entity that
controls, is controlled by or is under common control with Roche, in each case, that is not controlled by Genentech. 

  

	(b)	Amended IRA means the Second Amended and Restated Investors’ Rights Agreement among Tercica and the other parties thereto substantially in the form attached
hereto as Exhibit A. 

  

	(c)	Acquiring Person shall have the meaning ascribed to it in Section 1(a) of the Rights Agreement. 

  

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	(d)	Beneficial Owner and any of its correlative meanings, including Beneficially Own, Beneficially Owned or the like, shall have the meaning ascribed to it
in Section 1(d) of the Rights Agreement. 

  

	(e)	Business Day means a day, other than Saturday, Sunday or other day on which commercial banks in New York, New York are authorized or required by Law to close.

  

	(f)	Closing means the First Closing, the Second Option Closing and/or the Milestone Closing, as applicable. 

  

	(g)	Combination Product Agreement means that certain Combination Product Development and Commercialization Agreement, dated as of July 6, 2007, by and between Tercica
and Genentech, as the same may be amended from time to time. 

  

	(h)	Common Stock means Tercica’s common stock, par value $0.001 per share. 

  

	(i)	Disclosure Schedule means that certain disclosure schedule delivered by Tercica to Genentech concurrently herewith and identified as the “Disclosure
Schedule.” 

  

	(j)	Effective Date shall have the meaning ascribed to it in Section 16.15(b) of the Combination Product Agreement. 

  

	(k)	Exchange Act means the Securities Exchange Act of 1934, as amended. 

  

	(l)	Execution Date means July 6, 2007. 

  

	(m)	Expiration of the First Option shall have the meaning ascribed to it in Section G.1(b)(i) of Exhibit G to the Combination Product Agreement.

  

	(n)	Fair Market Value means the average of the closing prices of the Common Stock on Principal Market for the twenty (20) trading days ending on the applicable
Reference Date. 

  

	(o)	First Closing shall have the meaning ascribed to it in Section 2.2(a)(i). 

  

	(p)	First Closing Date means the date on which the First Closing occurs. 

  

	(q)	First Closing Limit means 842,105 shares of Common Stock (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the date of
this Agreement). 

  

	(r)	First Option shall have the meaning ascribed to it in Section 2.2(b) of the Combination Product Agreement. 

  

	(s)	First Option Expiration Date means the date of the Expiration of the First Option. 

  

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	(t)	First Tranche Shares shall have the meaning ascribed to it in Section 2.2(a)(iii). 

  

	(u)	GAAP means United States generally accepted accounting principles. 

  

	(v)	Genentech Opt-In and any of its correlative meanings, including Genentech Opted-In, Genentech Opts-In or the like, means the exercise by
Genentech of its First Option or its Second Option in accordance with the terms of the Combination Product Agreement. 

  

	(w)	Genentech Opt-Out and any of its correlative meanings, including Genentech Opted-Out, Genentech Opts-Out or the like, shall have the
meaning ascribed to it in Section 2.8 of the Combination Product Agreement. 

  

	(x)	Genentech Share Limit means the lesser of (a) such number of shares of Common Stock held of record by Genentech as shall equal 19.9% of the Common Stock then
outstanding or (b) such number of shares of Common Stock Beneficially Owned by Genentech as would cause Genentech to become an Acquiring Person. 

  

	(y)	Governmental Entities means any foreign or United States federal, state, county, local municipal or other governmental, regulatory or administrative authority, agency,
commission or other instrumentality, any court, tribunal or arbitral body with competent jurisdiction, or any national securities exchange or automated quotation service. 

  

	(z)	HSR Act means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and the regulations and rules issued pursuant to that Act.

  

	(aa)	Initial Purchase Request Notice means the notice of a purchase request provided to Genentech by Tercica in accordance with the terms of Section G.1(a)(iii) of Exhibit
G to the Combination Product Agreement. 

  

	(bb)	 Intellectual Property Rights means all of the rights arising from or in respect of the following, whether protected, created or arising under the Laws
of the United States or any foreign jurisdiction: (A) (i) any valid and enforceable letters patent granted by, or a patent application filed with any applicable supranational, national, federal, state or local regulatory agency,
department, bureau or other governmental entity of any country or jurisdiction worldwide that is charged with reviewing and/or issuing patents, including, without limitation, any extension, registration, confirmation, reissue, continuation,
division, continuation-in-part, re-examination, supplementary protection certificate or renewal thereof, or any foreign equivalent of any of the foregoing and (ii) any certificates of invention for a U.S. letters patent, or any foreign
equivalent thereof (collectively, Patents); (B) trademarks, service marks, trade names (whether registered or unregistered), service names, industrial designs, brand names, brand marks, trade dress rights, internet domain names,
identifying symbols, logos, emblems, signs or insignia, and including all goodwill associated with the foregoing, (C) copyrights, whether registered or 

  

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unregistered (including copyrights in computer software programs), mask work rights and registrations and applications therefor (collectively,
Copyrights); (D) confidential and proprietary information, or non-public processes, designs, specifications, technology, know-how, techniques, formulas, inventions, concepts, trade secrets, discoveries, ideas and technical data
and information, in each case excluding any rights in respect of any of the foregoing that comprise or are protected by Copyrights or Patents (collectively, Trade Secrets); and (E) all applications, registrations and permits
related to any of the foregoing clauses (A) through (D). 

  

	(cc)	Ipsen means Ipsen, S.A., a société anonyme organized under the laws of France. 

  

	(dd)	Key Employee shall have the meaning ascribed to it in Section 3.9(c) of this Agreement. 

  

	(ee)	Knowledge means, with respect to a Person, the actual knowledge of any of its executive officers. 

  

	(ff)	Law means any judgment, order, statute, law (including common law), ordinance, rule, permit or regulation applicable to a Person or its business, properties or assets.

  

	(gg)	Letter Agreement means that certain letter agreement, dated as of July 6, 2007, by and between Tercica and Genentech amending that certain License and
Collaboration Agreement, effective as of April 15, 2002, as amended, and regarding that certain International License and Collaboration Agreement, effective as of July 25, 2003, as amended. 

  

	(hh)	 Material Adverse Effect, with respect to a Person, means: (i) a material adverse effect on the financial condition, properties, business or
results of operations of such Person and its Subsidiaries, taken as a whole or (ii) a material adverse effect on the ability of such Person to perform its material obligations under this Agreement or the other Transaction Documents; provided
that none of the following shall be deemed either alone or in combination to constitute, and none of the following shall be taken into account in determining whether there has been or would be, a Material Adverse Effect on any Person:
(a) any adverse effect resulting from or arising out of general economic conditions to the extent that such conditions do not disproportionately affect such Person and its Subsidiaries, taken as a whole, (b) any adverse effect resulting
from or arising out of general conditions in the industries in which such Person and its Subsidiaries operate to the extent that such conditions do not disproportionately affect such Person and its Subsidiaries, taken as a whole, (c) any
adverse effect resulting from or arising out of any natural disaster or any acts of terrorism, sabotage, military action or war or any escalation or worsening thereof to the extent they do not disproportionately affect such Person and its
Subsidiaries, taken as a whole, (d) any adverse change in reported financial results to the extent such change results from or arises out of changes (after the date of this Agreement) in GAAP or applicable Laws, (e) a 

  

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reduction in market price of such Person’s common stock on the stock markets on which it trades to the extent such reduction is not related to factors
that individually or in the aggregate would reasonably be expected to have a Material Adverse Effect, or (f) any adverse effect resulting from or arising out of the failure of such Person to achieve projected financial results except to the
extent that such failure is related to operational issues or other factors that individually or in the aggregate would reasonably be expected to have a Material Adverse Effect. 

  

	(ii)	Milestone Closing shall have the meaning ascribed to it in Section 2.2(c)(i) of this Agreement. 

  

	(jj)	Milestone Closing Date means the date on which the Milestone Closing occurs. 

  

	(kk)	Milestone Closing Limit means 1,052,632 shares of Common Stock (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the
date of this Agreement). 

  

	(ll)	Milestone Event Date shall have the meaning ascribed to it in Section G.1(c)(i) of Exhibit G to the Combination Product Agreement. 

  

	(mm)	Milestone Purchase Request Notice means the notice of a purchase request provided to Genentech by Tercica in accordance with the terms of Section G.1(c)(i) of Exhibit
G to the Combination Product Agreement. 

  

	(nn)	Milestone Tranche Shares shall have the meaning ascribed to it in Section 2.2(c)(ii) of this Agreement. 

  

	(oo)	Order shall have the meaning ascribed to it in Section 6.1(h) of this Agreement. 

  

	(pp)	Parties means Tercica and Genentech. 

  

	(qq)	Person means any individual or any corporation, limited liability company, partnership, trust, association or other entity of any kind. 

  

	(rr)	Principal Market means The NASDAQ Global Market or such other exchange or market as is then the principal market or exchange on which the Common Stock is traded.

  

	(ss)	Purchase Documents means this Agreement and the Amended IRA. 

  

	(tt)	Reference Date means, as applicable, (A) with respect to the First Closing, the trading date immediately prior to the Execution Date, (B) with respect to the
Second Option Closing, the trading date immediately prior to the First Option Expiration Date and (C) with respect to the Milestone Closing, the trading date immediately prior to the Milestone Event Date. 

  

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	(uu)	Reference Price means $4.75 (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the date of this Agreement).

  

	(vv)	Rights Agreement means that certain Rights Agreement, dated as of October 13, 2006, by and between Tercica and Computershare Trust Company, N.A., as the same may
be amended from time to time. 

  

	(ww)	SEC means the United States Securities Exchange Commission. 

  

	(xx)	Second Option shall have the meaning ascribed to it in Section 2.3(b) of the Combination Product Agreement. 

  

	(yy)	Second Option Closing shall have the meaning ascribed to it in Section 2.2(b)(i) of this Agreement. 

  

	(zz)	Second Option Closing Date means the date on which the Second Option Closing occurs. 

  

	(aaa)	Second Option Closing Limit means 842,105 shares of Common Stock (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the
date of this Agreement). 

  

	(bbb)	Second Option Notice shall have the meaning ascribed to it in Section G.1(b)(i) of Exhibit G to the Combination Product Agreement. 

  

	(ccc)	Second Option Purchase Request Notice means the notice of a purchase request provided to Genentech by Tercica in accordance with the terms of Section G.1(b)(iii) of
Exhibit G to the Combination Product Agreement. 

  

	(ddd)	Second Option Tranche Shares shall have the meaning ascribed to it in Section 2.2(b)(iii) of this Agreement. 

  

	(eee)	Securities Act means the Securities Act of 1933, as amended. 

  

	(fff)	SEC Website means the website maintained by the SEC at http://www.sec.gov. 

  

	(ggg)	Shares means the shares of Common Stock to be issued and sold hereunder. 

  

	(hhh)	Subsidiary means any corporation or other organization, whether incorporated or unincorporated, of which (i) fifty percent (50%) or more of the securities
(or other interests having by their terms ordinary voting power to elect a majority of the board of directors or equivalent governing body of such corporation or other organization) is directly or indirectly owned or controlled by the relevant
Person or (ii) the relevant Person (or any other subsidiary of the relevant Person) is a general partner. 

  

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	(iii)	Tercica Balance Sheet means the balance sheet of Tercica contained in the Tercica SEC Report for the quarter ended March 31, 2007. 

  

	(jjj)	Tercica Financials means each of the financial statements (including, in each case, any related notes thereto) contained in the Tercica SEC Reports.

  

	(kkk)	Tercica Opt-Out and any of its correlative meanings, including Tercica Opted-Out, Tercica Opts-Out or the like, shall have the meaning ascribed to it in
Section 2.9 of the Combination Product Agreement. 

  

	(lll)	Tercica SEC Reports means Tercica’s most recent annual report on Form 10-K and all reports filed by Tercica pursuant to Section 13(a) or Section 15(d)
of the Exchange Act subsequent to the filing of Tercica’s most recent annual report on Form 10-K. 

  

	(mmm)	Third Party means any other Person other than Tercica or Genentech. 

  

	(nnn)	Transaction Documents means this Agreement, the Amended IRA, the Combination Product Agreement, the Letter Agreement and any other document or instrument contemplated
hereby or thereby. 

  

	1.2	Interpretation and Construction. In this Agreement: 

  

	(a)	the definitions of terms herein shall apply equally to the singular and plural forms of the terms defined; 

  

	(b)	whenever the context may require, any pronoun shall include the corresponding masculine, feminine and neuter forms; 

  

	(c)	the words “include”, “includes” and “including” shall be deemed to be followed by the phrase “without limitation”; 

 

	(d)	the word “will” shall be construed to have the same meaning and effect as the word “shall”; 

  

	(e)	any definition of or reference to any contract, agreement, document, instrument, commitment, license, undertaking or other record herein shall be construed as referring to such
contract, agreement, document, instrument, commitment, license, undertaking or other record as from time to time amended, supplemented, restated or otherwise modified; 

  

	(f)	any reference herein to any Person shall be construed to include such Person’s successors and permitted assigns; 

  

	(g)	the words “herein”, “hereof” and “hereunder”, and words of similar import, shall be construed to refer to this Agreement in its entirety and not to any
particular provision hereof; and 

  

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	(h)	unless the context otherwise requires, all references herein to Sections, Exhibits and Schedules shall be construed to refer to Sections, Exhibits and Schedules to, this Agreement.

 ARTICLE 2 
 PURCHASE AND SALE OF SHARES 
 2.1 Agreement to Issue, Sell and Purchase the Shares. Subject to the terms and the conditions hereof,
at the First Closing, the Second Option Closing and the Milestone Closing, Tercica will issue and sell to Genentech, and Genentech will purchase from Tercica, the number of Shares as hereafter determined at the respective purchase prices as
hereafter determined. 
 2.2 Closings, Delivery and Payment. 
  

	(a)	First Closing. 

  

	 	 (i)
	 Subject to the satisfaction or waiver (in accordance with the terms of this Agreement) of all of the conditions set
forth in Article 6, the initial closing of the sale and purchase of the Shares (the First Closing) shall occur at the offices of Cooley Godward Kronish LLP (at the address set forth in the notice provisions of Section 10.7 below), or at
such other place as agreed between the Parties, and shall, subject to the provisions of Section 2.2(a)(ii), take place (i) on a date within thirty (30) days of the Effective Date, which such date shall be mutually agreed to by the
Parties or (ii) if the First Closing shall not have occurred within thirty (30) days of the Effective Date, on a date to be mutually agreed to by the Parties, but in no event later than the tenth (10th) Business Day after the date on which all of the conditions contained in Article 6 have been satisfied or waived in accordance with the terms of this Agreement. 

  

	 	 (ii)
	 Notwithstanding Section 2.2(a)(i), if the Fair Market Value on the trading date immediately prior to the Execution
Date is less than the Reference Price, then the First Closing shall take place (i) on a date within thirty (30) Business Days of the date of receipt (as determined pursuant to the provisions of Section 10.7 below) by Genentech of the
Initial Purchase Request Notice, which such date shall be mutually agreed to by the Parties or (ii) if the First Closing shall not have occurred within thirty (30) Business Days of the date of receipt (as determined pursuant to the
provisions of Section 10.7 below) by Genentech of the Initial Purchase Request Notice, on a date to be mutually agreed to by the Parties, but in no event later than the tenth (10th) Business Day after the date on which all of the conditions contained in Article 6 have been satisfied or waived in accordance with the terms of this Agreement. 

  

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	 	(iii)	At the First Closing, Tercica will issue and sell to Genentech, and Genentech will purchase from Tercica, the number of Shares as shall equal four million dollars ($4,000,000)
divided by the Fair Market Value on the trading date immediately prior to the Execution Date, rounded down to the nearest whole Share; provided, however, that if the number of Shares to be issued at the First Closing (as determined in
accordance with the foregoing clause) would exceed the First Closing Limit, then the number of Shares to be issued and sold at the First Closing shall equal the First Closing Limit (the First Tranche Shares). Notwithstanding the
foregoing, if the number of First Tranche Shares to be issued and sold at the First Closing (as determined in accordance with the foregoing sentence) would cause Genentech to exceed the Genentech Share Limit, then the number of First Tranche Shares
shall be reduced to the extent (and only to the extent) necessary so as to not cause Genentech to exceed the Genentech Share Limit. 

  

	 	(iv)	At the First Closing, Tercica shall deliver or cause to be conveyed by Tercica’s transfer agent for delivery to Genentech one or more stock certificates in respect of the First
Tranche Shares in the name of Genentech (including, if Tercica has caused such stock certificates to be conveyed by Tercica’s transfer agent, evidence reasonably satisfactory to Genentech that Tercica has provided irrevocable delivery
instructions in respect of such stock certificates to Tercica’s transfer agent), and Genentech shall deliver to Tercica by wire transfer of same day funds the amount of the purchase price of the First Tranche Shares, which such purchase price
shall equal the number of First Tranche Shares (as determined in accordance with Section 2.2(a)(iii) above) multiplied by the Fair Market Value on the trading date immediately prior to the Execution Date. 

  

	(b)	Second Option Closing. 

  

	 	 (i)
	 Subject to the satisfaction or waiver (in accordance with the terms of this Agreement) of all of the conditions set
forth in Article 7, a subsequent closing of the sale and purchase of the Shares (the Second Option Closing) shall occur at the offices of Cooley Godward Kronish LLP (at the address set forth in the notice provisions of
Section 10.7 below), or at such other place as agreed between the Parties, and shall, subject to the provisions of Section 2.2(b)(ii), take place (i) on a date within thirty (30) days of the First Option Expiration Date, which
such date shall be mutually agreed to by the Parties or (ii) if the Second Option Closing shall not have occurred within thirty (30) days of the First Option Expiration Date, on a date to be mutually agreed to by the Parties, but in no
event later than the tenth (10th) Business Day after the date on which all of the conditions contained in Article 7 have been satisfied or waived
in accordance with the terms of this Agreement. 

  

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	 	 (ii)
	 Notwithstanding Section 2.2(b)(i), if the Fair Market Value on the trading date immediately prior to the First
Option Expiration Date is less than the Reference Price, then the Second Option Closing shall take place (i) on a date within thirty (30) Business Days of the date of receipt (as determined pursuant to the provisions of Section 10.7
below) by Genentech of the Second Option Purchase Request Notice, which such date shall be mutually agreed to by the Parties or (ii) if the Second Option Closing shall not have occurred within thirty (30) Business Days of the date of
receipt (as determined pursuant to the provisions of Section 10.7 below) by Genentech of the Second Option Purchase Request Notice, on a date to be mutually agreed to by the Parties, but in no event later than the tenth (10th) Business Day after the date on which all of the conditions contained in Article 7 have been satisfied or waived in accordance with the terms of
this Agreement. 

  

	 	(iii)	At the Second Option Closing, Tercica will issue and sell to Genentech, and Genentech will purchase from Tercica, the number of Shares as shall equal four million dollars
($4,000,000) divided by the Fair Market Value on the trading date immediately prior to the First Option Expiration Date, rounded down to the nearest whole Share; provided, however, that if the number of Shares to be issued at the
Second Option Closing (as determined in accordance with the foregoing clause) would exceed the Second Option Closing Limit, then the number of Shares to be issued and sold at the Second Option Closing shall equal the Second Option Closing Limit (the
Second Option Tranche Shares). Notwithstanding the foregoing, if the number of Second Option Tranche Shares to be issued and sold at the Second Option Closing (as determined in accordance with the foregoing sentence) would cause
Genentech to exceed the Genentech Share Limit, then the number of Second Option Tranche Shares shall be reduced to the extent (and only to the extent) necessary so as to not cause Genentech to exceed the Genentech Share Limit.

  

	 	(iv)	At the Second Option Closing, Tercica shall deliver or cause to be conveyed by Tercica’s transfer agent for delivery to Genentech one or more stock certificates in respect of
the Second Option Tranche Shares in the name of Genentech (including, if Tercica has caused such stock certificates to be conveyed by Tercica’s transfer agent, evidence reasonably satisfactory to Genentech that Tercica has provided irrevocable
delivery instructions in respect of such stock certificates to Tercica’s transfer agent), and Genentech shall deliver to Tercica by wire transfer of same day funds the amount of the purchase price of the Second Option Tranche Shares which such
purchase price shall equal the number of Second Option Tranche Shares (as determined in accordance with Section 2.2(b)(iii) above) multiplied by the Fair Market Value on the trading date immediately prior to the First Option Expiration Date.

  

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	(c)	Milestone Closing. 

  

	 	 (i)
	 Subject to the satisfaction or waiver (in accordance with the terms of this Agreement) of all of the conditions set
forth in Article 8, a subsequent closing of the sale and purchase of the Shares (the Milestone Closing) shall occur at the offices of Cooley Godward Kronish LLP (at the address set forth in the notice provisions of Section 10.7
below), or at such other place as agreed between the Parties, and shall take place (i) on a date within thirty (30) Business Days of the date of receipt (as determined pursuant to the provisions of Section 10.7 below) by Genentech of
the Milestone Purchase Request Notice, which such date shall be mutually agreed to by the Parties or (ii) if the Milestone Closing shall not have occurred within thirty (30) Business Days of the date of receipt (as determined pursuant to
the provisions of Section 10.7 below) by Genentech of the Milestone Purchase Request Notice, on a date to be mutually agreed to by the Parties, but in no event later than the tenth (10th) Business Day after the date on which all of the conditions contained in Article 8 have been satisfied or waived in accordance with the terms of this Agreement. 

  

	 	(ii)	At the Milestone Closing, Tercica will issue and sell to Genentech, and Genentech will purchase from Tercica, the number of Shares as shall equal five million dollars
($5,000,000) divided by the Fair Market Value on the trading date immediately prior to the Milestone Event Date, rounded down to the nearest whole Share; provided, however, that if the number of Shares to be issued at the Milestone
Closing (as determined in accordance with the foregoing clause) would exceed the Milestone Closing Limit, then the number of Shares to be issued and sold at the Milestone Closing shall equal the Milestone Closing Limit (the Milestone Tranche
Shares). Notwithstanding the foregoing, if the number of Milestone Tranche Shares to be issued and sold at the Milestone Closing (as determined in accordance with the foregoing sentence) would cause Genentech to exceed the Genentech Share
Limit, then the number of Milestone Tranche Shares shall be reduced to the extent (and only to the extent) necessary so as to not cause Genentech to exceed the Genentech Share Limit. 

  

	 	(iii)	At the Milestone Closing, Tercica shall deliver or cause to be conveyed by Tercica’s transfer agent for delivery to Genentech one or more stock certificates in respect of the
Milestone Tranche Shares in the name of Genentech (including, if Tercica has caused such stock certificates to be conveyed by Tercica’s transfer agent, evidence reasonably satisfactory to Genentech that Tercica has provided irrevocable delivery
instructions in respect of such stock certificates to Tercica’s transfer agent), and Genentech shall deliver to Tercica by wire transfer of same day funds the amount of the purchase price of the Milestone Tranche Shares, which such purchase
price shall equal the number of Milestone Tranche Shares (as determined in accordance with Section 2.2(c)(ii) above) multiplied by the Fair Market Value on the trading date immediately prior to the Milestone Event Date.

  

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	(d)	Proceedings at the Closings. All actions to be taken and all documents not attached as exhibits to this Agreement to be executed and delivered by Tercica in connection with
the consummation of the transactions contemplated at each Closing shall be reasonably satisfactory in form and substance to Genentech and its counsel, and all actions to be taken and all documents not attached as exhibits to this Agreement to be
executed and delivered by Genentech in connection with the consummation of the transactions contemplated at each Closing shall be reasonably satisfactory in form and substance to Tercica and its counsel. All actions to be taken and all documents to
be executed and delivered by all parties hereto at each Closing shall be deemed to have been taken and executed and delivered simultaneously, and no action shall be deemed taken nor any document executed or delivered until all have been taken,
executed, and delivered. Each Closing shall be deemed to have occurred when all conditions have been met or waived and all deliverables have been delivered. 

 ARTICLE 3 
 REPRESENTATIONS AND WARRANTIES OF TERCICA 
 Tercica hereby represents and warrants to Genentech that, except as set forth in the Tercica SEC Reports and the Disclosure Schedule, the following are true and correct:

 3.1 Organization and Qualification. Tercica is a corporation duly organized, validly existing and in good standing under the laws of the State of
Delaware and has all requisite corporate power and authority to own, lease and operate its properties and to carry on its business as presently conducted. Tercica is qualified to do business as a foreign corporation in each jurisdiction in which
qualification is required except where failure to be so qualified would not reasonably be expected to have a Material Adverse Effect on Tercica. 
 3.2
Authorized Capital Stock. Tercica’s authorized capital stock consists of (i) 100,000,000 shares of Common Stock, of which as of March 31, 2007 (A) 50,162,610 shares of Common Stock were issued and outstanding,
(B) 1,683,729 shares of Common Stock were reserved for future issuance under Tercica’s 2004 Stock Plan, 2002 Stock Plan, 2002 Executive Stock Plan and 2004 Employee Stock Purchase Plan (the “Plans”), (C) 5,196,012 shares of
Common Stock were reserved for issuance upon the exercise of outstanding options granted under the Plans, (D) 8,405,524 shares of Common Stock were reserved for issuance upon the exercise of an outstanding warrant and the conversion of a senior
convertible promissory note, in each case issued to Ipsen and (E) 260,000 shares were reserved for issuance upon the exercise of an outstanding warrant issued to Kingsbridge Capital Limited, and (ii) 5,000,000 shares of Preferred Stock,
1,000,000 of which are designated Series A Junior Participating Preferred Stock, none of which are 

  

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issued and outstanding. Tercica has not issued any shares since March 31, 2007 other than pursuant to employee or director equity incentive plans or
purchase plans approved by the Board of Directors of Tercica. The issued and outstanding shares of Common Stock have been duly authorized and validly issued, are fully paid and nonassessable, have been issued in compliance with all federal and state
securities laws and were not issued in violation of or subject to any preemptive rights or other rights to subscribe for or purchase securities. Tercica does not have outstanding any options to purchase, or any preemptive rights or other rights to
subscribe for or to purchase, any securities or obligations convertible into, or any contracts or commitments to issue or sell, shares of its capital stock and there are no agreements or commitments obligating Tercica to repurchase, redeem, or
otherwise acquire capital stock or other securities of Tercica. There are no agreements to which Tercica is a party or by which it is bound with respect to the voting (including voting trusts or proxies), registration under the Securities Act, or
sale or transfer (including agreements relating to pre-emptive rights, rights of first refusal, co-sale rights or “drag-along” rights) of any securities of Tercica. 
 3.3 No Interest in any Person. Tercica does not own, directly or indirectly, any capital stock, membership interests, partnership interest, joint venture interest or other equity interest (or interest that is
convertible into, or exchangeable or executable for, any of the foregoing) in any Person. 
 3.4 Issuance, Sale and Delivery of Shares. The issuance,
sale and delivery of the Shares have been duly authorized by all necessary corporate action and, when issued, delivered and paid for in accordance with the terms hereof, will be duly authorized, validly issued, fully paid and nonassessable. No
further approval or authorization of the Board of Directors of Tercica, the stockholders of Tercica or any other Person will be required for the issuance and sale of any Shares to be issued and sold by Tercica as contemplated herein. 
 3.5 Authorization; Due Execution, Delivery and Performance of this Agreement. Tercica has full legal right, corporate power and authority to enter into the
Purchase Documents, issue the Shares and perform the transactions contemplated by the Purchase Documents. Each of the Purchase Documents will upon delivery be duly authorized, executed and delivered by Tercica. The making, issuing and performance of
the Purchase Documents by Tercica and the consummation of the transactions therein contemplated will not (i) violate any provision of the organizational documents of Tercica, (ii) result in the creation of any lien, charge, security
interest or encumbrance upon any assets of Tercica pursuant to the terms or provisions of, or will not conflict with, result in the breach or violation of, or constitute, either by itself or upon notice or the passage of time or both, a default
under, or give any person any rights of termination, amendment, acceleration or cancellation of, any agreement, commitment, mortgage, deed of trust, lease, franchise, license, indenture, permit or other instrument (A) to which Tercica is a
party or by which Tercica or its properties may be bound or affected and (B) which individually or in the aggregate would be reasonably likely to result in a material liability of Tercica or have a Material Adverse Effect, or (iii) violate
any statute or any authorization, judgment, decree, order, rule or regulation of any court or any regulatory body, administrative agency or 

  

 Page 13 

 
other governmental body applicable to Tercica or any of its properties in a manner that would reasonably be expected to have a Material Adverse Effect. No
consent, approval, authorization or other order of any court, regulatory body, administrative agency or other governmental body is required for the execution and delivery by Tercica of the Purchase Documents or the consummation by Tercica of the
transactions contemplated thereby, other than such as have been made or obtained and except for compliance with the Blue Sky laws and federal securities laws applicable to the offering of the Shares. Upon their execution and delivery, and assuming
the valid execution thereof by Genentech and the other parties thereto, the Purchase Documents will constitute the valid and binding obligations of Tercica, enforceable in accordance with their respective terms, except as enforceability may be
limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ and contracting parties’ rights generally and except as enforceability may be subject to general principles of equity (regardless
of whether such enforceability is considered in a proceeding in equity or at law). 
 3.6 Valid Offering. Assuming the accuracy of the representations
and warranties of Genentech set forth in Article 4, the offer, sale, and issuance of the Shares will be exempt from the registration requirements of the Securities Act and will have been registered or qualified (or are exempt from registration
and qualification) under the registration or qualification requirements of all applicable state securities Laws. 
 3.7 No Defaults. Tercica is not in
violation or default of any provision of its certificate of incorporation or bylaws, or other organizational documents. Except as to defaults, violations and breaches which, individually or in the aggregate, would not reasonably be expected to have
a Material Adverse Effect on Tercica, Tercica is not in breach of or default with respect to any provision of any agreement, judgment, decree, order, mortgage, deed of trust, lease, franchise, license, indenture, permit or other instrument to which
it is a party or by which it or any of its properties are bound and has not received any written notice of termination under any such documents, which termination would reasonably be expected to have a Material Adverse Effect on Tercica; and there
does not exist any state of fact which, with notice or lapse of time or both, would constitute an event of default on the part of Tercica as defined in such documents, except such defaults which individually or in the aggregate would not reasonably
be expected to have a Material Adverse Effect on Tercica. 
 3.8 No Material Change. Between March 31, 2007 and the date hereof, (i) Tercica
has not incurred, other than in the ordinary course of business, any material liabilities or obligations which would be required under GAAP to be set forth on Tercica’s balance sheet, except for legal, accounting and other costs in connection
with the negotiation, execution and delivery by Tercica of the Transaction Documents, (ii) Tercica has not sustained any material loss or interference with its business or properties from fire, flood, windstorm, accident or other calamity,
(iii) Tercica has not paid or declared any dividends or other distributions with respect to its capital stock, (iv) Tercica is not in default in the payment of principal or interest on any outstanding debt obligations, and (v) there
have been no events or occurrences which, individually or in the aggregate, have had or would reasonably be expected to have a Material Adverse Effect on Tercica. 
  

 Page 14 

	3.9	Intellectual Property. 

  

	(a)	To the best of Tercica’s Knowledge, the use, practice or other commercial exploitation of the Intellectual Property Rights owned by or licensed to Tercica and the operation of
Tercica’s business as presently conducted does not infringe, constitute an unauthorized use of or misappropriate any rights owned or controlled by any third Person including Intellectual Property Rights of any third Person in a way that would
be reasonably likely to have a Material Adverse Effect on Tercica. Tercica is not a party to or the subject of any pending or, to Tercica’s Knowledge, threatened suit, action, investigation or proceeding which involves a claim against Tercica,
of infringement, unauthorized use, or violation of any Intellectual Property Rights of any Person, or challenges the ownership, use, validity or enforceability of any Intellectual Property Rights or contests the right of Tercica to use, exercise,
license, transfer or dispose of any Intellectual Property Rights owned by or licensed to Tercica, or any products, processes or materials covered thereby in any manner. 

  

	(b)	No Person (including employees and former employees of Tercica), to Tercica’s Knowledge, is infringing, violating, misappropriating or otherwise misusing any Intellectual
Property Rights owned by or licensed to Tercica, and Tercica has not made any such claims against any Person (including employees and former employees of Tercica). 

  

	(c)	No Trade Secret or any other non-public, proprietary information which is material to the business of Tercica as presently conducted has been authorized to be disclosed or, to
Tercica’s Knowledge, has been actually disclosed by Tercica to any employee or any third Person other than (i) pursuant to a confidentiality or non-disclosure agreement restricting the disclosure and use of the Intellectual Property Rights
owned by or licensed to Tercica, or (ii) to such employees or third persons who otherwise have a duty of confidentiality to Tercica. Each current and former Key Employee has entered into an agreement containing appropriate confidentiality and
invention assignment provisions. For purposes of this Section 3.9(c), Key Employee means any officer of Tercica as well as any employee of Tercica who either alone or in concert with others develops any Intellectual Property
Rights owned by or licensed to Tercica. 

  

	(d)	Tercica has taken all commercially reasonable steps to protect and preserve the confidentiality and value of all Intellectual Property Rights and any other confidential information
owned by or licensed to Tercica. 

  

	3.10	Compliance. 

  

	(a)	Tercica has complied in all material respects with each Law binding on it or on any of its assets or properties and is not currently in violation of any such Law, in the case of
each of the foregoing, the noncompliance with which would reasonably be expected to result in Material Adverse Effect on Tercica. Tercica has not received any written notices or orders of noncompliance issued to Tercica under or in respect of any
such Law. 

  

 Page 15 

	(b)	Tercica has all franchises, permits, licenses, consents and other governmental or regulatory authorizations and approvals necessary for the conduct of its business as presently
conducted, except for such of the foregoing, the failure to possess which, individually or in the aggregate, would not reasonably be expected to have a Material Adverse Effect on Tercica. 

 3.11 Litigation. Tercica has not received notice of the assertion of, been threatened with or otherwise gained Knowledge of facts reasonably likely to result in,
any action, suit, proceeding, claim, arbitration or investigation, before any Governmental Entity against Tercica which would reasonably be expected to result in a material liability to, or have a Material Adverse Effect on, Tercica in the event of
an adverse outcome or that in any manner challenges or seeks to or would otherwise prevent, enjoin, alter or delay any of the transactions contemplated by the Transaction Documents. There is no order of any governmental entity binding on Tercica or
any of its assets or properties. 
 3.12 Labor. Tercica is not a party to any labor or collective bargaining agreement, and no employees of Tercica
are represented by any labor organization. Within the preceding three years, there have been no representation or certification proceedings, or petitions seeking a representation proceeding, pending or, to Tercica’s Knowledge, threatened to be
brought or filed with the National Labor Relations Board or any other labor relations tribunal or authority. Within the preceding three years, to Tercica’s Knowledge, there have been no organizing activities involving Tercica in respect of any
group of employees of Company. There are no strikes, work stoppages, slowdowns, lockouts, material arbitrations, or material grievances or other material labor disputes pending or, to Tercica’s Knowledge, threatened against or involving
Tercica. 
 3.13 Corrupt Practices. Neither Tercica nor, to Tercica’s Knowledge, any agent or other person acting on behalf of Tercica, has
(i) directly or indirectly, used any corporate funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreign or domestic
government officials or employees or to foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by Tercica or made by any person acting on its behalf and of which Tercica is
aware in violation of law, or (iv) violated in any material respect any provision of the Foreign Corrupt Practices Act of 1977, as amended. 
 3.14
SEC Filings; Financial Statements. 
  

	(a)	 Since January 1, 2007, Tercica has filed all forms, reports and documents required to be filed with the SEC, except to the extent that failure to so file would
not reasonably be expected to be material to an investor. Such filings are available to Genentech on the SEC Website. In addition, all exhibits to the Tercica SEC Reports are available on the SEC Website, except to the extent of Confidential 

  

 Page 16 

	 	 
Treatment Requests granted by the SEC. All documents required to be filed as exhibits to the Tercica SEC Reports have been so filed, and all material
contracts that were filed as exhibits to Tercica’s most recent Form 10-K filing are in full force and effect, except those which have expired in accordance with their terms, and Tercica is not in default thereunder, except where any such
default has not resulted in or would not reasonably be expected to result in a loss of any material right granted to Tercica thereunder. As of their respective filing dates, the Tercica SEC Reports (i) complied in all material respects with the
requirements of the Exchange Act and the rules and regulations of the SEC thereunder applicable to such Tercica SEC Reports, and (ii) did not at the time they were filed (or if amended or superseded by a filing prior to the date of this
Agreement, then on the date of such filing) contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under
which they were made, not misleading. 

  

	(b)	The Tercica Financials (i) complied as to form in all material respects with applicable accounting requirements and with the published rules and regulations of the SEC with
respect thereto as of their respective dates, (ii) were prepared in accordance with GAAP applied on a consistent basis throughout the periods involved and consistent with each other (except as may be indicated in the notes thereto or, in the
case of unaudited interim financial statements, as may be permitted by the SEC on Form 10-Q under the Exchange Act), and (iii) fairly presented the financial position of Tercica as at the respective dates thereof and the consolidated results of
operations and cash flows for the periods indicated, except that the unaudited interim financial statements were reasonably expected to be subject to normal and recurring year-end adjustments which would not be material in amount. There has been no
material change in Tercica’s accounting policies except as described in the notes to the Tercica Financials. As of the date of the Tercica Financials, Tercica did not have any obligations or liabilities (absolute, accrued, contingent or
otherwise) of any nature required to be disclosed on a balance sheet or in the related notes to the financial statements prepared in accordance with GAAP which are, individually or in the aggregate, material to the business, results of operations or
financial condition of Tercica, except liabilities (x) provided for in the Tercica Balance Sheet or (y) which would not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect on Tercica.

 3.15 Corporate Records. Tercica has delivered or made available to Genentech true and complete copies of all corporate records
requested in writing by Genentech in connection with its decision to purchase the Shares. 
 3.16 NASDAQ Compliance and Listing. The Common Stock is
registered pursuant to Section 12(b) of the Exchange Act and is listed on The NASDAQ Global Market, and Tercica has taken no action that is designed to, or is likely to have the effect of, terminating the registration of the Common Stock under
the Exchange Act or delisting the 

  

 Page 17 

 
Common Stock from The NASDAQ Global Market. Tercica shall comply in all material respects with all requirements of the Nasdaq Stock Market with respect to
the listing of the Shares on The NASDAQ Global Market. 
 3.17 Reservation of Common Stock. As of the date hereof, Tercica has available (and will
keep available at all times), free of preemptive rights and other similar contractual rights of stockholders, shares of Common Stock for the purpose of enabling Tercica to satisfy any obligation to issue the Shares. 
 3.18 Broker’s Fee. There are no brokers or finders entitled to compensation in connection with the sale of the Shares to Genentech. 
 ARTICLE 4 
 REPRESENTATIONS AND
WARRANTIES OF GENENTECH 
 Genentech hereby represents and warrants to Tercica as follows: 
 4.1 Organization and Qualification. Genentech is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and, together with its Subsidiaries, has all
requisite corporate power and authority to own, lease and operate its and its Subsidiaries’ properties and to carry on its and its Subsidiaries’ business as presently conducted. 
 4.2 Investment Representations. Genentech is knowledgeable, sophisticated and experienced in making, and is qualified to make, decisions with respect to
investments in securities, including the Shares, and (without limiting any representation or warranty provided by Tercica herein) has requested, received, reviewed and considered all information it deems relevant in making an informed decision to
purchase the Shares. Genentech is acquiring the Shares for its own account for investment only and with no present intention of distributing any of such Shares or any arrangement or understanding with any other persons regarding the distribution of
such Shares within the meaning of Section 2(11) of the Securities Act. Genentech is an “accredited investor” within the meaning of Rule 501 of Regulation D promulgated under the Securities Act. Genentech understands that the Shares
have not been registered under the Securities Act or registered or qualified under any state securities laws in reliance on specific exemptions therefrom, which exemptions may depend upon, among other things, the bona fide nature of
Genentech’s investment intent as expressed herein. 
 4.3 Authorization; Due Execution, Delivery and Performance of this Agreement. Genentech has
full legal right, corporate power and authority to enter into the Purchase Documents and perform the transactions contemplated thereunder. Each of the Purchase Documents upon delivery will be duly authorized, executed and delivered by Genentech. The
making, issuing and performance of the Purchase Documents by Genentech and the consummation of the transactions therein contemplated will not: (i) violate any provision 

  

 Page 18 

 
of the organizational documents of Genentech, (ii) violate any statute or any authorization, judgment, decree, order, rule or regulation of any court or
any regulatory body, administrative agency or other Governmental Entity applicable to Genentech, or (iii) violate any material contract, agreement, or instrument to which Genentech is a party or by which it is bound, that would reasonably be
expected to have a material adverse effect on Genentech’s ability to perform its obligations under the Purchase Documents. No consent, approval, authorization or other order of any court, regulatory body, administrative agency or other
governmental body is required for the execution and delivery by Genentech of the Purchase Documents or the consummation by Genentech of the transactions contemplated thereby, other than such as have been made or obtained. Upon their execution and
delivery, and assuming the valid execution thereof by Tercica and the other parties thereto, the Purchase Documents will constitute the valid and binding obligations of Genentech enforceable in accordance with their respective terms, except as
enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ and contracting parties’ rights generally and except as enforceability may be subject to general principles
of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law). 
 4.4 No Legal or Tax Advice. Genentech
understands that nothing in the Transaction Documents, the Tercica SEC Reports or any other materials presented to Genentech in connection with the purchase and sale of the Shares constitutes legal or tax advice. Genentech has consulted such legal
and tax advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase of the Shares. Genentech understands that it (and not Tercica) shall be responsible for its own tax liabilities that may arise as a
result of this investment or the transactions contemplated by the Purchase Documents. 
 4.5 No Defaults. Neither Genentech nor any of its
Subsidiaries is in violation or default of any provision of its organizational documents or any agreement, judgment, decree, order, mortgage, deed of trust, lease, franchise, license, indenture, permit or other instrument to which it is a party or
by which it or any of its properties are bound, and has not received any written notice of termination under any such material documents, and there does not exist any state of fact which, with notice or lapse of time or both, would constitute an
event of default on the part of Genentech or any of its Subsidiaries as defined in such documents, in each case which would reasonably be expected to have a material adverse effect on Genentech’s ability to perform its obligations under the
Purchase Documents. 
 4.6 Compliance. Genentech and each of its Subsidiaries have complied in all material respects with each Law binding on it or on
any of its assets or properties and is not currently in violation of any such Law, and there have been no written notices or orders of noncompliance issued to Genentech or its Subsidiaries under or in respect of any such Law, in each case the
noncompliance with which would reasonably be expected to have a material adverse effect on Genentech’s ability to perform its obligations under the Purchase Documents. 
  

 Page 19 

 4.7 Litigation. Neither Genentech nor any of its Subsidiaries has received written notice of the assertion of, or
to the knowledge of Genentech, been threatened with any action, suit, proceeding, claim, arbitration or investigation before any Governmental Entity against Genentech or any of its Subsidiaries or order of any Governmental Entity binding on
Genentech, its Subsidiaries or any of their respective assets or properties, in the case of all the foregoing, which would reasonably be expected to have a material adverse effect on Genentech’s ability to perform its obligations under the
Purchase Documents. 
 4.8 Restrictive Legend. Genentech understands that, until such time as a registration statement covering the Shares has been
declared effective or the Common Stock associated with such Shares may be sold pursuant to Rule 144 under the Securities Act without any restriction as to the number of securities as of a particular date that can then be immediately sold, the Shares
shall bear a restrictive legend in substantially the following form (and a stop-transfer order may be placed against transfer of the certificates for the Shares): 
 “THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THE SECURITIES MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR
THE SECURITIES UNDER SAID ACT, OR AN OPINION OF COUNSEL, IN FORM, SUBSTANCE AND SCOPE REASONABLY ACCEPTABLE TO THE COMPANY, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR UNLESS SOLD PURSUANT TO RULE 144 UNDER SAID ACT.” 
 ARTICLE 5 
 COVENANTS

 5.1 Cooperation. 
  

	(a)	Each Party hereto shall cooperate with the other to fulfill the closing conditions set forth in Article 6, Article 7 and Article 8, including delivery of all documents set forth in
such conditions. 

  

	(b)	 Without limiting the foregoing, each party hereto shall take all commercially reasonable steps necessary or desirable, and proceed diligently and in good faith and
shall use all commercially reasonable efforts to obtain, as promptly as practicable, all authorizations, consents, orders and approvals of all Governmental Entities that may be or become necessary for such party’s execution and delivery of, and
the performance of its obligations pursuant to, this Agreement and the other Transaction Documents, including, if applicable, under the HSR Act. Subject to each party’s determination of the need to file under the HSR Act, each party hereto
shall make all necessary filings to be made by them, and thereafter make any other required or appropriate submissions, with respect to this Agreement, the other 

  

 Page 20 

	 	 
Transaction Documents and the transactions contemplated hereby and thereby required under the HSR Act and each party shall make, as soon as reasonably
practicable, all other necessary filings to be made by it, and thereafter make any other required or appropriate submissions, with respect to this Agreement, the other Transaction Documents and the transactions contemplated hereby and thereby. Each
party will cooperate fully (including, without limitation, by providing all information and reasonable assistance as the other party requests in connection with its preparation of any filing or submission that is necessary under the HSR Act) with
the other parties in promptly seeking to obtain all such authorizations, consents, orders and approvals. 

  

	(c)	Each party hereto shall promptly inform the other party of any communication from any Governmental Entity regarding any of the transactions contemplated by this Agreement. If any
Party or Affiliate thereof receives a request for additional information or documentary material from any such Governmental Entity in respect of the transactions contemplated hereby, then such party will endeavor in good faith to make, or cause to
be made, as soon as reasonably practicable and after consultation with the other party, an appropriate response in compliance with such request. 

 5.2 Notice of Certain Events. Each party shall, promptly after it obtains Knowledge thereof, notify the other of: 
  

	(a)	any notice or other communication from any Person alleging that the consent of such Person is or may be required in connection with the transactions contemplated by this Agreement
and the other Transaction Documents; 

  

	(b)	any notice or other communication from any Governmental Entity in connection with the review, clearance or approval of the transactions contemplated by this Agreement and the other
Transaction Documents; and 

  

	(c)	any legal proceeding commenced or threatened against, relating to or involving or otherwise affecting such party that relates to the consummation of the transactions contemplated by
this Agreement and the other Transaction Documents. 

 ARTICLE 6 
 CONDITIONS TO FIRST CLOSING 
 6.1 Tercica’s
obligations set forth in Section 2.2(a) of this Agreement shall be subject to the following conditions, any one or more of which may be waived by Tercica (to the extent legally permissible): 
  

	(a)	 Representations and Warranties True. The representations and warranties made by Genentech in Article 4 hereof shall be true and correct in all material
respects (and 

  

 Page 21 

	 	 
any representations and warranties qualified by materiality shall be true and correct in all respects) as of the date of this Agreement, except to the extent
such representations and warranties expressly related to any earlier date, in which case such representations and warranties shall be true and correct in all material respects on and as of such earlier date. 

  

	(b)	Compliance with Covenants. Genentech shall have performed and complied in all material respects with all covenants and agreements contained in this Agreement that are
required to be performed or complied with by it on or before the First Closing. 

  

	(c)	Effective Date. The Effective Date shall have occurred. 

  

	(d)	Initial Purchase Request Notice. In the event that Section 2.2(a)(ii) is applicable, Tercica shall have provided the Initial Purchase Request Notice.

  

	(e)	Litigation. No action, suit or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation of
the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the other
Transaction Documents. 

  

	(f)	Amended IRA. The Amended IRA substantially in the form attached hereto as Exhibit A shall have been executed and delivered by the necessary parties thereto.

  

	(g)	HSR Act. All applicable waiting periods, if any, in respect of the transactions contemplated hereby and by the other Transaction Documents under the HSR Act shall have
expired or terminated. 

  

	(h)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Law, judgment, decree, injunction or other order (whether
temporary, preliminary or permanent) that is in effect and restrains, enjoins or otherwise prohibits consummation of the transactions contemplated by this Agreement or the other Transaction Documents or materially modifies any material term of this
Agreement or the other Transaction Documents or the related transactions contemplated hereby and thereby (collectively, an Order), and no Governmental Entity shall have instituted any proceeding seeking any such Order.

  

	(i)	Other Authorizations, Consents etc. All other material authorizations, consents, orders or approvals of, or declarations or filings with, or expirations of waiting periods
imposed by, any Governmental Entity necessary for the consummation of the transactions contemplated hereby and by the other Transaction Documents shall have been obtained or filed, or shall have occurred. 

  

 Page 22 

	(j)	Certificate. Genentech shall have delivered to Tercica a certificate executed by an officer of Genentech, dated as of the First Closing Date, as to the matters set forth in
this Sections 6.1(a) and 6.1(b) above. 

 6.2 Genentech’s obligation set forth in Section 2.2(a) of this Agreement shall be subject
to the following conditions, any one or more of which may be waived by Genentech (to the extent legally permissible): 
  

	(a)	Representations and Warranties True. The representations and warranties of Tercica in Article 3 hereof shall be true and correct in all material respects (and any
representations and warranties qualified by materiality shall be true and correct in all respects) as of the date of this Agreement, except to the extent such representations and warranties expressly related to any earlier date, in which case such
representations and warranties shall be true and correct in all material respects on and as of such earlier date. 

  

	(b)	Compliance with Covenants. Tercica shall have performed and complied with in all material respects all covenants and agreements contained in this Agreement that are required
to be performed or complied with by it on or before the First Closing. 

  

	(c)	Disclosure. As of the First Closing Date, the Tercica SEC Reports (each as amended, supplemented or superseded as of the First Closing Date) shall not contain any untrue
statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. 

 

	(d)	Effective Date. The Effective Date shall have occurred. 

  

	(e)	Initial Purchase Request Notice. In the event that Section 2.2(a)(ii) is applicable, Tercica shall have provided the Initial Purchase Request Notice.

  

	(f)	Litigation. No action, suit, or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation
of the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the
other Transaction Documents. 

  

	(g)	Amended IRA. The Amended IRA substantially in the form attached hereto as Exhibit A shall have been executed and delivered by the necessary parties thereto.

  

	(h)	HSR Act. All applicable waiting periods, if any, in respect of the transactions contemplated hereby and by the other Transaction Documents under the HSR Act shall have
expired or terminated. 

  

 Page 23 

	(i)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Order, and no Governmental Entity shall have instituted any
proceeding seeking any such Order. 

  

	(j)	Other Authorizations, Consents etc. All other material authorizations, consents, orders or approvals of, or declarations or filings with, or expirations of waiting periods
imposed by, any Governmental Entity necessary for the consummation of the transactions contemplated hereby and by the other Transaction Documents shall have been obtained or filed, or shall have occurred. 

  

	(k)	Certificate. Tercica shall have delivered to Genentech a certificate executed by an officer of Tercica, dated the First Closing Date, as to the matters set forth in Sections
6.2(a), 6.2(b) and 6.2(c) above. 

 ARTICLE 7 
 CONDITIONS TO SECOND OPTION CLOSING 
 7.1 Tercica’s obligations set forth in
Section 2.2(b) of this Agreement shall be subject to the following conditions, any one or more of which may be waived by Tercica (to the extent legally permissible): 
  

	(a)	Effective Date. The Effective Date shall have occurred. 

  

	(b)	Second Option Notice. Genentech shall have validly provided the Second Option Notice. 

  

	(c)	Second Option Purchase Request Notice. In the event that Section 2.2(b)(ii) is applicable, Tercica shall have provided the Second Option Purchase Request Notice.

  

	(d)	Litigation. No action, suit or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation of
the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the other
Transaction Documents. 

  

	(e)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Order, and no Governmental Entity shall have instituted any
proceeding seeking any such Order. 

 7.2 Genentech’s obligation set forth in Section 2.2(b) of this Agreement shall be subject to
the following conditions, any one or more of which may be waived by Genentech (to the extent legally permissible): 
  

	(a)	Effective Date. The Effective Date shall have occurred. 

  

 Page 24 

	(b)	Second Option Notice. Genentech shall have validly provided the Second Option Notice. 

  

	(c)	Second Option Purchase Request Notice. In the event that Section 2.2(b)(ii) is applicable, Tercica shall have provided the Second Option Purchase Request Notice.

  

	(d)	Disclosure. As of the Second Option Closing Date, the Tercica SEC Reports (each as amended, supplemented or superseded as of the Second Option Closing Date) do not contain
any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.

  

	(e)	Litigation. No action, suit or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation of
the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the other
Transaction Documents. 

  

	(f)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Order, and no Governmental Entity shall have instituted any
proceeding seeking any such Order. 

  

	(g)	Certificate. Tercica shall have delivered to Genentech a certificate executed by an officer of Tercica, dated the Second Option Closing Date, as to the matters set forth in
Section 7.2(d) above. 

 ARTICLE 8 
 CONDITIONS TO MILESTONE CLOSING 
 8.1 Tercica’s obligations set forth in
Section 2.2(c) of this Agreement shall be subject to the following conditions, any one or more of which may be waived by Tercica (to the extent legally permissible): 
  

	(a)	Effective Date. The Effective Date shall have occurred. 

  

	(b)	Milestone Event Date. The Milestone Event Date shall have occurred. 

  

	(c)	Opt-In. A Genentech Opt-In shall have occurred prior to the Milestone Event Date. 

  

 Page 25 

	(d)	Absence of Opt-Outs. Neither a Genentech Opt-Out nor a Tercica Opt-Out shall have occurred under the Combination Product Agreement prior to the Milestone Event Date.

  

	(e)	Milestone Purchase Request Notice. Tercica shall have provided the Milestone Purchase Request Notice. 

  

	(f)	Litigation. No action, suit or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation of
the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the other
Transaction Documents. 

  

	(g)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Order, and no Governmental Entity shall have instituted any
proceeding seeking any such Order. 

 8.2 Genentech’s obligation set forth in Section 2.2(c) of this Agreement shall be subject to
the following conditions, any one or more of which may be waived by Genentech (to the extent legally permissible): 
  

	(a)	Effective Date. The Effective Date shall have occurred. 

  

	(b)	Milestone Event Date. The Milestone Event Date shall have occurred. 

  

	(c)	Opt-In. A Genentech Opt-In shall have occurred prior to the Milestone Event Date. 

  

	(d)	Absence of Opt-Outs. Neither a Genentech Opt-Out nor a Tercica Opt-Out shall have occurred under the Combination Product Agreement prior to the Milestone Event Date.

  

	(e)	Milestone Purchase Request Notice. Tercica shall have provided the Milestone Purchase Request Notice. 

  

	(f)	Disclosure. As of the Milestone Closing Date, the Tercica SEC Reports (each as amended, supplemented or superseded as of the Milestone Closing Date) do not contain any untrue
statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. 

 

	(g)	Litigation. No action, suit or proceeding shall have been initiated or threatened with the probable or reasonably likely effect of enjoining or preventing the consummation of
the transactions contemplated hereby and by the other Transaction Documents or seeking (with the probable or reasonably likely effect of receiving) material damages on account the consummation of the transactions contemplated hereby and by the other
Transaction Documents. 

  

 Page 26 

	(h)	Orders. No Governmental Entity of competent jurisdiction shall have enacted, issued, promulgated or entered any Order, and no Governmental Entity shall have instituted any
proceeding seeking any such Order. 

  

	(i)	Certificate. Tercica shall have delivered to Genentech a certificate executed by an officer of Tercica, dated the Milestone Closing Date, as to the matters set forth in
Section 8.2(f) above. 

 ARTICLE 9 
 TERMINATION 
 9.1 Termination. 
  

	(a)	This Agreement shall terminate: 

  

	 	(i)	in its entirety upon the valid termination of the Combination Product Agreement in its entirety in accordance with its terms or by operation of Law; 

  

	 	(ii)	with respect to Section 2.2(a), if Section 2.2(a)(ii) is applicable and Tercica shall have not provided the Initial Purchase Request Notice within fifteen
(15) Business Days of the Effective Date; 

  

	 	(iii)	with respect to Section 2.2(b), if either (A) Genentech shall have not validly provided the Second Option Notice within (30) days of the First Option Expiration Date
or (B) Section 2.2(b)(ii) is applicable and Tercica shall have not provided the Second Option Purchase Request Notice within fifteen (15) Business Days of receipt (as determined pursuant to the provisions of Section 10.7 below)
by Tercica of the Second Option Notice; provided, that if Genentech validly provides the Second Option Notice to Tercica and Tercica does not provide a timely Second Option Purchase Request Notice, Genentech shall acquire the Second Option
without purchasing the Second Option Tranche Shares; and 

  

	 	(iv)	with respect to Section 2.2(c), (A) in the event of a Genentech Opt-Out or a Tercica Opt-Out under the Combination Product Agreement prior to the Milestone Event Date,
(B) in the absence of a Genentech Opt-In prior to the Milestone Event Date or (C) if Tercica shall have not provided the Milestone Purchase Request Notice within fifteen (15) Business Days of the Milestone Event Date.

  

	(b)	This Agreement may be terminated at any time by mutual written consent of Genentech and Tercica. 

  

 Page 27 

 For the avoidance of doubt, in the event of a termination of this Agreement pursuant to this Section 9.1, nothing
herein shall require Genentech to purchase from Tercica or Tercica to sell to Genentech any Shares pursuant hereto after the date of such termination. 
 9.2
Effect of Termination. In the event that this Agreement is validly terminated as provided herein, then each of the parties shall be relieved of their duties and obligations arising under this Agreement after the date of such termination and
such termination shall be without liability or obligation to Genentech or Tercica; provided, however, that such termination will not affect (a) any rights that have accrued to the benefit of either Party prior to the date of such
termination, including damages arising from any breach of this Agreement and (b) either Party’s liability for any breach of this Agreement such Party may have committed prior to the date of such termination. The provisions of this
Section 9.2 and Article 10 (Miscellaneous) shall survive any termination hereof pursuant to Section 9.1 hereof. 
 ARTICLE 10 
 MISCELLANEOUS 
 10.1 Assignment. Neither Party may assign this Agreement to a Third Party without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed. Notwithstanding the foregoing,
(a) without the prior written consent of Tercica, Genentech may assign this Agreement in its entirety to any of its Affiliates, provided that any such assignment shall not relieve the Genentech of its responsibilities for performance of its
obligations under this Agreement and (b) without the prior written consent of the other Party, either Party may assign this Agreement in its entirety in connection with a merger or similar reorganization or the sale of all or substantially all
of its assets. Any attempted assignment in violation of this Section 10.1 shall be void and of no effect. All valid assignments shall be binding upon and inure to the benefit of and be enforceable by and against the successors and permitted
assigns of Genentech or Tercica, as the case may be. If either Party assigns this Agreement under clause (b) above or seeks and obtains the other Party’s consent to assign this Agreement in its entirety to a Third Party, the assignee shall
assume all obligations of its assignor under this Agreement. 
 10.2 No Survival. The representations and warranties made herein shall terminate as of
the First Closing. All statements as to factual matters contained in any certificate or other instrument delivered by or on behalf of a Party pursuant hereto in connection with the transactions contemplated hereby shall be deemed to be
representations and warranties by such Party hereunder solely as of the date of such certificate or instrument. 
 10.3 Waiver. Except as specifically
provided for herein, the waiver from time to time by either of the Parties of any of such Party’s rights or such Party’s failure to exercise any remedy shall not operate or be construed as a continuing waiver of same or of any other of
such Party’s rights or remedies provided in this Agreement. 
  

 Page 28 

 10.4 Expenses. Whether or not the transactions contemplated hereby are consummated, (a) the legal,
accounting, financing and due diligence expenses incurred by Genentech in connection with such transactions will be borne by Genentech and (b) the legal and other costs and expenses incurred by Tercica in connection with the transactions
contemplated hereby will be borne by Tercica. 
 10.5 Further Assurances. Each Party shall duly execute and deliver, or cause to be duly executed and
delivered, such further instruments and do and cause to be done such further acts and things, including, without limitation, the filing of such assignments, agreements, documents and instruments, as may be necessary or as the other Party may
reasonably request in connection with this Agreement or to carry out more effectively the provisions and purposes hereof, or to better assure and confirm unto such other Party its rights and remedies under this Agreement. 
 10.6 Force Majeure. No failure or omission by the Parties in the performance of any obligation of this Agreement shall be deemed a breach of this Agreement or
create any liability if the same shall arise from any cause or causes beyond the control of the Parties (including, without limitation, the following: acts of God; acts or omissions of any government; any rules, regulations or orders issued by any
governmental authority or by any officer, department, agency or instrumentality thereof; fire; flood; storm; earthquake; accident; acts of war or terrorism; rebellion; insurrection; riot and invasion), provided that such failure or omission
resulting from one of the foregoing causes is cured as soon as practicable after its occurrence. 
 10.7 Notices. Any notice required under this
Agreement shall be in writing and shall specifically refer to this Agreement. Notices shall be sent via one of the following means and will be effective (a) on the date of delivery, if delivered in person; (b) on the date of receipt, if
sent by a facsimile (with delivery confirmed); or (c) on the date of receipt, if sent by private express courier or by first class certified mail, return receipt requested. Any notice sent via facsimile shall be followed by a copy of such
notice by private express courier or by first class mail. Notices shall be sent to the other Party at the addresses set forth below. Either Party may change its addresses for purposes of this Section 10.7 by sending notice to the other Party.

  

			
	If to Tercica, to:	  	
		
		  	Tercica, Inc.
		  	2000 Sierra Point Parkway, Suite 400
		  	Brisbane, CA 94005 U.S.A.
		  	Attention: General Counsel
		  	Facsimile: (650) 238-1520
		
		  	With a required copy (which shall not constitute notice) to:
		
		  	Cooley Godward Kronish LLP Five Palo Alto Square

  

 Page 29 

			
	 	  	 3000 El Camino Real
 Palo Alto, California
94306

		  	Attention: Suzanne Sawochka Hooper
		  	Facsimile: (650) 849-7400
		
	If to Genentech, to:	  	
		
		  	 Genentech, Inc.
 1 DNA Way
 South San Francisco, CA 94080

		  	 Attention: Corporate Secretary
 Facsimile: (650) 952-9881

		
		  	With a required copy (which shall not constitute notice) to:
		
		  	Genentech, Inc.
		  	 1 DNA Way
 South San Francisco, CA 94080
 Attention: VP, Alliance Management and Pipeline
 Strategy
Support

		  	Facsimile: (650) 467-3294
		
		  	With a required copy (which shall not constitute notice) to:
		
		  	 Genentech, Inc.
 1 DNA Way
 South San Francisco, CA 94080

		  	 Attention: Treasurer
 Facsimile: (650)
225-8680

 10.8 Captions and Construction. Titles, headings and other captions are for convenience only and are not to
be used for interpreting this Agreement. Ambiguities, if any, in this Agreement shall not be construed against any Party, irrespective of which Party may be deemed to have drafted the Agreement or authorized the ambiguous provision. 
 10.9 Severability. If any provision hereof should be held invalid, illegal or unenforceable in any respect, then, to the fullest extent permitted by applicable
law, (a) all other provisions hereof shall remain in full force and effect and shall be liberally construed in order to carry out the intent of the Parties as nearly as may be possible, and (b) the Parties agree to negotiate provisions, in
replacement of the provision held invalid, illegal or unenforceable, that is consistent with applicable law and accomplishes, as nearly as possible, the original intention of the Parties with respect thereto. To the fullest extent permitted by
applicable law, each Party hereby waives any provision of law that would render any provision hereof prohibited or unenforceable in any respect. 
  

 Page 30 

 10.10 Governing Law. This Agreement shall be governed and interpreted in accordance with the substantive laws of
the State of California notwithstanding the provisions governing conflicts of laws under such law of the State of California to the contrary. 
 10.11
Counterparts; Facsimiles. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. For purposes hereof, a facsimile copy of
this Agreement, including the signature pages hereto, will be deemed to be an original. Notwithstanding the foregoing, the Parties shall deliver original execution copies of this Agreement to one another as soon as practicable following execution
thereof. 
 10.12 Entire Agreement. This Agreement, the other Transaction Documents, the Disclosure Schedule and the other agreements, documents and
instruments contemplated hereby and referenced herein sets forth all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties hereto and supersedes and terminates all warranties,
representations, conditions or understandings, either oral or written, between the Parties with respect to the subject matter hereof. No subsequent alteration, amendment, change or addition to this Agreement shall be binding upon the Parties hereto
unless reduced to writing and signed by the respective authorized representatives of the Parties. 
 10.13 No Third-Party Beneficiaries. This
Agreement is intended for the benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other person. 
 [SIGNATURES APPEAR ON FOLLOWING PAGE] 
  

 Page 31 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by their duly authorized
representatives as of the day and year first above written. 
  

			
	TERCICA, INC.
		
	 By:
	 	 /s/ Stephen N. Rosenfield

	 Name:
	 	Stephen N. Rosenfield
	 Title:
	 	Executive Vice President of Legal Affairs, General Counsel and Secretary
	
	GENENTECH, INC.
		
	 By:
	 	 /s/ David A. Ebersman

	 Name:
	 	David A. Ebersman
	 Title:
	 	Executive Vice President and Chief Financial Officer

 [Signature Page for Common Stock Purchase Agreement]Addendum to Manufacturing Services Agreement

 EXHIBIT 10.8C 
 EXECUTION COPY 
 ADDENDUM TO THE 
 MANUFACTURING SERVICES AGREEMENT 
 THIS ADDENDUM (“Addendum”) to that
certain Manufacturing Services Agreement (the “Agreement”) dated December 20, 2002 by and between Cambrex Bio Science Baltimore, Inc. (“CBSB”) and Tercica Medica, Inc., as amended by that certain Amendment No. 1 dated
November 10, 2006 by and between CBSB and Tercica, Inc. (f/k/a Tercica Medica, Inc.) (“Tercica”), is entered into by and between Tercica and Lonza Baltimore, Inc. (“Lonza”) and is effective as of May 11, 2007 (the
“Addendum Effective Date”). Defined terms used but not otherwise defined herein shall have the meanings ascribed to them in the Agreement. 
 WHEREAS, Lonza is the successor in interest to CBSB (each of Lonza and Tercica sometimes hereinafter referred to as a “Parties” and, collectively, the “Parties”); and 
 WHEREAS, the Parties desire to execute this Addendum to the Agreement. 
 NOW, THEREFORE, in consideration of the mutual covenants set forth in this Addendum, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby
agree as follows: 
  

	1.	Additional 2007 Campaigns. 

 (a) The Parties
agree that [ * ] additional Batches of Drug Substance shall be manufactured by Lonza at its facility located at 5901 East Lombard Street, Baltimore, Maryland 21224; provided, however that upon the placement by Tercica and acceptance by Lonza
of any order for a Batch, such order shall become binding upon the Parties (the “2007 Additional Batches”). For purposes of clarity, the 2007 Additional Batches are in addition to the current Firm Order for [ * ] Batches for
delivery in 2007 (the “2007 Batches”). Should Tercica fail to take any of the 2007 Additional Batches, Tercica shall remain obligated to pay for such of the 2007 Additional Batch(es) at the Batch Price (as defined below) as if it accepted
delivery of same. Notwithstanding the foregoing, the [ * ] Batches (comprising the 2007 Batches and the 2007 Additional Batches) may be reduced by the number of non-conforming Batch(es), subject to a maximum of [ * ] non-conforming
Batches. 
 (b) The Parties agree that at any time prior to September 30, 2007, Tercica may place an order for Batches of Drug
Substance in addition to the 2007 Additional Batches, and LONZA shall not refuse acceptance of any such order except for the number of such Batches of Drug Substance in excess of [ * ], if any (the lesser of the total number of Batches in
such order and [ * ], the “Minimum Extended Order Acceptance Requirement”); provided, however, that Lonza shall only be obligated to use reasonable 

  

 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED
AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
 1. 

 EXECUTION COPY 
  

 
commercial efforts to manufacture the number of Batches in the Minimum Extended Order Acceptance Requirement. Once the Parties have mutually agreed in
writing as to the number of Batches of Drug Substance in any such order (subject to the Minimum Extended Order Acceptance Requirement) placed under this Section 1(b) (the “2007 Extended Batches”), Lonza shall be obligated to deliver,
and Tercica shall be obligated to purchase, all Batch(es) in the 2007 Extended Batches. Should Tercica not require delivery for any Batch(es) in the 2007 Extended Batches, Tercica shall remain obligated to pay for such Batch(es) at the Batch Price
as if it accepted delivery of same. 
 (c) The 2007 Additional Batches and the 2007 Extended Batches (if any) shall meet the warranties
set forth in Section 17.1 of the Agreement. The Parties further agree that this Addendum shall exclusively set forth the commercial terms for the supply of the 2007 Additional Batches and 2007 Extended Batches and, to the extent that any terms
set forth herein conflict with any term or provision set forth in the Agreement, the terms in the Addendum shall control. 
 (d)
Tercica shall reimburse Lonza [ * ] per each key employee (as mutually determined by the Parties prior to commencement of manufacture of the 2007 Additional Batches) retained by Lonza to manufacture the 2007 Additional Batches, up to a
maximum of [ * ] key employees (the “Reimbursement Amount”). The Reimbursement Amount shall be due, owing and payable by Tercica to Lonza immediately upon completion of the 2007 Additional Batches, regardless of (i) whether the
Parties agree to a number of 2007 Extended Batches or (ii) the completion of the 2007 Extended Batches. 
 (e) In the event that
Lonza rejects any of the 2007 Batches, the 2007 Additional Batches or the 2007 Extended Batches, due to a failure to meet the warranties set forth in Section 17.1 of the Agreement, then Tercica shall not be obligated to pay the Acquisition Cost
for materials used in the manufacture of said rejected Batch(es). 
  

	2.	2007 Batch Price. 

 The price per Batch is equal to
the sum of (i) [ * ] per Batch plus (ii) the Acquisition Cost for any materials used in the manufacture of such Batch of the Drug Substance (the “Batch Price”). 
  

	3.	Negotiation of new MSA and termination of Agreement. 

 (a) The Parties agree that they shall commence good faith negotiations toward the execution of a new Manufacturing Services Agreement to replace the Agreement which shall provide for, among other things, the manufacture of Drug
Substance at Lonza’s Hopkinton, MA facility on a [ * ] liter scale. 
 (b) The Parties further agree that upon delivery of
and receipt of payment for the last Batch of the 2007 Additional Batches or 2007 Extended Batches (as applicable), the Agreement shall terminate. 
  

 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED
AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
 2. 

 EXECUTION COPY 
  

	4.	Continuance of Terms and Conditions. 

 All terms and
conditions of the Agreement not modified by this Addendum shall continue in full force and effect in accordance with their terms. 
 IN
WITNESS WHEREOF, the Parties have caused this Addendum to be executed as of the Addendum Effective Date. 
  

							
	TERCICA, INC.	 	LONZA BALTIMORE, INC.
				
	By:	 	 /s/ Andrew J. Grethlein
	 	By:	 	 /s/ Anthony Rotunno

	Name:	 	Andrew J. Grethlein	 	Name:	 	Anthony Rotunno
	Title: 	 	SVP, Pharmaceutical Operations	 	Title: 	 	VP, U.S. Microbial Operations
	Date: 	 	14 May 07	 	Date: 	 	14 May 07

  

 [ * ] = CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED
AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
 3.

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