Document:

Filed by Bowne Pure Compliance

EXHIBIT 10.8

AMENDMENT NO. 1

TO

AMENDED AND RESTATED EMPLOYMENT AGREEMENT

AMENDMENT (“Amendment”) made effective on December 31, 2008 to the amended and restated
employment agreement dated as of May 1, 2006 (the “Employment Agreement”), among Celgene
Corporation, a Delaware corporation (the “Company”), and Robert J. Hugin (the “Executive”).

WHEREAS, the Company and the Executive have previously entered into the Employment Agreement;
and

WHEREAS, the Company and the Executive desire to amend the Employment Agreement in a manner
intended to comply with Section 409A of the Internal Revenue Code of 1986, as amended.

NOW, THEREFORE, effective December 31, 2008, the Employment Agreement is hereby amended as
follows:

1. Section 3(d) of the Employment Agreement is hereby amended to insert a new sentence at the
end thereof to read as follows:

“Notwithstanding the foregoing, such stock options may not be
exercised beyond their stated term.”

2. Section 3(f) of the Employment Agreement is hereby amended to insert a new sentence at the
end thereof to read as follows:

“Any reimbursements made pursuant to this Section 3(f) shall be
subject to Section 22(c) hereof.”

3. Section 4 of the Employment Agreement is hereby amended to insert a new sentence at the end
thereof to read as follows:

“Any reimbursements made pursuant to this Section 4 shall be subject
to Section 22(c) hereof.”

 

 

 

4. The last paragraph of Section 10(c) is hereby amended in its entirety to read as follows:

“With respect to the health benefits under (iii) above, Employee (and,
if applicable, Employee’s dependents) shall timely elect continuation
of group health coverage following the termination of Employee’s
employment in accordance with the Consolidated Omnibus Budget
Reconciliation Act, as amended (“COBRA”). Provided that
Employee timely elects COBRA coverage, the Company shall reimburse
Employee (and, if applicable, Employee’s dependents), for a period of
eighteen (18) months following Employee’s termination for the monthly
premium for such COBRA coverage in an amount equal to 600% of such
monthly premium on a tax grossed-up basis (to the extent such monthly
premium is taxable), payable in a lump sum on the first payroll date
following the six (6) month anniversary of the date of termination,
and, beginning on the first day of the seventh (7th) month
following the date of termination, the Company shall pay to Employee
on the first payroll date in each month following the termination date
an amount equal to 100% of the monthly premium for such COBRA coverage
for the applicable month on a tax grossed-up basis (to the extent such
monthly premium is taxable). Following the expiration of the
applicable COBRA period, in the event the plan under which Employee
and his dependents were receiving health benefits immediately prior to
Employee’s date of termination is not fully-insured, then the Company
shall either, as determined by the Company in its sole discretion: (A)
provide health coverage to Employee and his dependents pursuant to a
fully-insured replacement policy or (B) in lieu of such health
coverage, pay Employee for the remainder of the three-year period,
monthly cash payments equal to the premium cost the Company would have
otherwise paid for such benefits for Employee and Employee’s
dependents, on a tax grossed-up basis, as determined on the
termination date (adjusted for increase in the cost-of-living index,
as defined in Treasury regulation § 1.401(a)(9)-6, Q&A-14(b)(2)). In
lieu of the above, in the event the plan under which Employee and his
dependents were receiving health benefits immediately prior to
Employee’s date of termination is fully-insured and the terms of such
plan permit Employee and Employee’s dependents to remain covered
thereunder following his termination of employment, then Employee and
Employee’s dependents shall receive continued coverage under such plan
to the extent permitted thereunder and any such coverage shall run
concurrently with the COBRA period following the date of termination.”

5. The first sentence of Section 10(d) of the Employment Agreement is hereby amended to insert
“Except to the extent provided in Section 10(e)” at the beginning thereof.

 

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6. Section 10(e) of the Employment Agreement is hereby amended to the following at the end
thereof to read as follows:

“Notwithstanding the foregoing, with respect to a termination pursuant
to Section 10(c) upon a Change in Control due to Employee’s
termination without Cause or for Good Reason within ninety (90) days
prior to a Change in Control, Change in Control shall mean the
occurrence of the following:

(i) any person (as defined in Section 3(a)(9) of the Exchange Act and
as used in Sections 13(d) and 14(d) thereof), excluding the Company,
any subsidiary of the Company and any employee benefit plan sponsored
or maintained by the Company or any subsidiary of the Company
(including any trustee of any such plan acting in his capacity as
trustee), becoming the “beneficial owner” (as defined in Rule 13d-3
under the Exchange Act) of securities of the Company representing
thirty percent (30%) of the total combined voting power of the
Company’s then outstanding securities;

(ii) a Transaction other than (A) a Transaction involving only the
Company and one or more of its subsidiaries, or (B) a Transaction
immediately following which the stockholders of the Company
immediately prior to the Transaction continue to have a majority of
the voting power in the resulting entity and no person (other than
those covered by the exceptions in (a) above) becomes the beneficial
owner of securities of the resulting entity representing more than
twenty-five percent (25%) of the voting power in the resulting entity;

(iii) during any period of one (1) year beginning on or after the date
hereof, the Incumbent Directors ceasing (for any reason other than
death) to constitute at least a majority of the Board or the board of
directors of any successor to the Company, provided that, any director
who was not a director as of the date hereof shall be deemed to be an
Incumbent Director if such director was elected to the board of
directors by, or on the recommendation of or with the approval of, a
majority of the directors who then qualified as Incumbent Directors
either actually or by prior operation of the foregoing, unless such
election, recommendation or approval occurs as a result of an actual
or threatened election contest (as such terms are used in Rule 14a-11
of Regulation 14A promulgated under the Exchange Act or any successor
provision) or any other actual or threatened solicitation of proxies
or contests by or on behalf of a person other than a member of the
Board; or

(iv) the consummation of a sale of all or substantially all of the
Company’s assets other than the sale of all or substantially all of
the assets of the Company to a person or persons who beneficially own,
directly or indirectly, at least fifty percent (50%) or more of the
combined voting power of the outstanding voting securities of the
Company at the time of such sale.

Notwithstanding anything herein to the contrary, the definition of
Change in Control for purposes of this Section 10(e) shall only
constitute a Change in Control for this purpose if the Change in
Control constitutes a “change in the ownership of the corporation,” a
“change in the effective control of a corporation” or a “change in the
ownership of a substantial portion of a corporation’s assets” pursuant
to Section 409A of the Code.”

 

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7. Section 11(a) of the Employment Agreement is hereby amended to insert a new sentence at the
end thereof to read as follows:

“The reduction of the Company Payments to the Reduced Amount, if
applicable, shall be made by reducing the payments and benefits under
the following sections in the following order: (i) Section 10(c)(iv);
(ii) Section 10(c)(i); and (iii) Section 10(c)(iii).”

8. The first sentence of Section 11(c) of the Employment Agreement is hereby amended in its
entirety to read as follows:

“For purposes of determining the amount of the Gross-up Payment,
Employee shall be deemed to pay taxes at the actual marginal rates of
federal, state and local income taxation in the calendar year in which
any such Gross-up Payment is to be made.”

9. Section 11(d) of the Employment Agreement is hereby amended to insert a new sentence at the
end thereof to read as follows:

“Notwithstanding the foregoing, any Gross-up Payment shall in all
events be paid within 60 days following the date on which Employee is
required to remit the Excise Tax. In the event that the Company is
required to make an additional Gross-up Payment as a result of a later
and final determination by the Internal Revenue Service, then such
additional Gross-up Payment shall be paid by the Company no later than
the date by which such taxes were due to have been paid as a result of
such final and non-appealable determination, and in all events by the
end of the taxable year following the date of such determination, or
on such earlier date as payment is due to avoid the Employee becoming
subject to the entry of a judgment against him or other action by the
Internal Revenue Service to enforce such assessment.”

10. Section 22 of the Employment Agreement is hereby amended in its entirety to read as
follows:

“22. Section 409A of the Code.

(a) Although the Company does not guarantee to Employee any
particular tax treatment relating to the payments and benefits under
this Agreement, it is intended that such payments and benefits be
exempt from, or comply with, Section 409A of Code and the regulations
and guidance promulgated thereunder (collectively “Code Section
409A”), and all provisions of this Agreement shall be construed in
a manner consistent with the requirements for avoiding taxes or
penalties under Code Section 409A. If any provision of this
Agreement (or of any award of compensation, including equity
compensation or benefits) would cause Employee to incur any additional
tax or interest under Code Section 409A, the Company shall, upon
Employee’s specific request, use its reasonable business efforts to in
good faith reform such provision to comply with Code Section 409A;
provided, that to the maximum extent practicable, the original intent
and economic benefit to Employee and the Company of the applicable
provision shall be maintained, but the Company shall have no
obligation to make any changes that could create any additional
economic cost or loss of benefit to the Company.

 

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(b) To the extent a payment or benefit is deferred compensation
subject to Code Section 409A, a termination of employment shall not be
deemed to have occurred for purposes of any provision of this
Agreement providing for the payment of any amounts or benefits upon or
following a termination of employment unless such termination is also
a “separation from service” within the meaning of Code Section 409A
and, for purposes of any such provision of this Agreement, references
to a “termination,” “termination of employment” or like terms shall
mean “separation from service.”

(c) With regard to any provision herein that provides for
reimbursement of costs and expenses or in-kind benefits, except as
permitted by Code Section 409A, (i) the right to reimbursement or
in-kind benefits shall not be subject to liquidation or exchange for
another benefit; (ii) the amount of expenses eligible for
reimbursement, or in-kind benefits, provided during any taxable year
shall not affect the expenses eligible for reimbursement, or in-kind
benefits to be provided, in any other taxable year, provided,
that the foregoing clause (ii) shall not be violated with regard to
expenses reimbursed under any arrangement covered by Section 105(b) of
the Code solely because such expenses are subject to a limit related
to the period the arrangement is in effect; and (iii) such payments
shall be made on or before the last day of Employee’s taxable year
following the taxable year in which the expense was incurred.

(d) Whenever a payment under this Agreement specifies a payment period
with reference to a number of days (e.g., “payment shall be
made within ten (10) days following the date of termination”), the
actual date of payment within the specified period shall be within the
sole discretion of the Company.

(e) If under this Agreement, an amount is to be paid in two or more
installments, for purposes of Code Section 409A, each installment
shall be treated as a separate payment.”

 

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IN WITNESS WHEREOF, the undersigned has caused this Amendment to
be executed this 22nd day of December, 2008.

	 	 	 	 	 
	 	EXECUTIVE  	 
	 
	 	 	 	 
	 	 	/s/
Robert J. Hugin 
	 	Robert J. Hugin	 
	 
	 	 	 	 
	 	CELGENE CORPORATION	 
	 
	 	 	 	 
	 

	 	By:	/s/
Sol J. Barer	 
	 	 	 	Name:  Sol J. Barer
	 	 	 	Title:    Chief Executive Officer

 

6Filed by Bowne Pure Compliance

Exhibit 10.52

EMPLOYMENT AGREEMENT

between

Celgene
International Sàrl,

(“Employer”)

and

Mr. Aart Brouwer,

(“Employee”)

	1.	 	POSITION AND RESPONSIBILITIES

	 
	1.1	 	The Employer hereby employs the Employee and the Employee accepts employment
as Chairman International and Senior Advisor to Celgene Chairman and Chief Executive Officer.

	 
	1.2	 	The Employee’s responsibilities are specified by the Employer. The Employee’s
responsibilities may, from time to time, be modified by the Employer to perform other
assignments or assume further responsibilities. The Employee’s other rights and obligations shall not be affected by such modification.

	 
	1.3	 	Unless the Employer provides otherwise, the Employee reports to Dr. Sol J. Barer,
Chairman and Chief Executive Officer.

	 
	1.4	 	Place of work is presently Meggan and Boudry, Switzerland as business dictates and
time is flexible and will be guided and based on the needs of the business as appropriate. The Employee’s position includes a level of travel activities commensurate to
effectively perform the position responsibilities.

 

 

 

	2.	 	REMUNERATION

	 
	2.1	 	Salary

	 
	 	 	The Employee shall receive an annual gross base salary of CHF 500,000 paid in 12 equal
installments to be paid on the final payday of each month.

	 
	2.2	 	Bonus Payments

	 
	 	 	In addition to the fixed base salary in accordance with paragraph 2.1 above, the
Employee shall be entitled in year one of this two year contract to a performance bonus of
CHF 340,000 based on the achievement of agreed upon performance objectives and a performance
bonus of CHF 200,000 based on the achievement of agreed upon performance objectives in year
two.

	 
	2.3	 	Stock Options

	 
	 	 	Upon execution of this contract, pursuant to approval by the Compensation Committee of the
Board of Directors of Celgene Corporation, the Employee will receive
a one-time grant of a
stock option to purchase 25,000 shares of Celgene common stock. Grants are made at fair
market value on the date of the grant, and this grant will vest 25% each year for over a
four year vesting period.

	 
	2.4	 	Deductions

	 
	 	 	The salary and bonus payments are gross payments. The Employee’s share in the prevailing
premiums for social security insurances mandatory under Swiss law such as “AHV”, “IV”,
“ALV”, “EO” etc., as well as for the pension plan maintained by the Employer (cf.
paragraph. 4 hereafter) shall be deducted from the payments made to the Employee. In
addition, the Employee agrees he has provided to the Employer certification that he will
not be required to pay taxes at source. The Employee will himself have to report and pay
taxes.

	 
	2.3	 	Financial Planning

	 
	 	 	Each calendar year for the two year duration of this contract, Celgene will provide payment
up to CHF 17,000 for the sole purpose of financial planning.

	 
	2.5	 	Further Payments

	 
	 	 	Unless otherwise expressly agreed upon in writing, the payment of any other gratuities,
profit shares, premiums or other extra payments shall be on a voluntary basis, subject to
the provision that even repeated payments without the reservation of voluntarily shall not
create any legal claim for the Employee, either in respect to their cause or their amount,
either for the past or for the future.

 

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	3.	 	EXPENSES

	 
	3.1	 	The Employer shall reimburse the Employee upon submission of appropriate vouchers for
reasonable and customary business travel expenses in accordance with the
applicable Employer’s guidelines as in force from time to time. The Employee shall
submit such expense vouchers monthly.

	 
	3.2	 	In addition, the Employee
will be authorized to use the services of a company paid car
while commuting to Boudry for business related reasons.

	 
	4.	 	PENSION FUND

	 
	4.1	 	As the Employee have requested, he will only participate in a stakeholder based Pension
rather than that which is provided by Celgene to all employees. The Employee will be subject
to the mandatory requirements of the Federal Law on Occupational Old Age, Survivors and
Disability Benefit Plan (“BVG”). Employer and Employee shall pay their shares in the pension
plan according to the applicable pension regulations and the terms of the pension plan
administered by Winterthur Columna.

	 
	5.	 	SICKNESS / INSURANCE, “EMPLOYEE’S PREVENTION FROM WORK”

	 
	5.1	 	If the Employee is by no fault of his own and due to reasons inherent in his person, such as
for example sickness, accident or military service, prevented from performing work, the
Employer will, after the first three months of employment, continue to pay the Employee’s
salary according to the following:

	 	 	 
	1–90 days

	 	100% of insured base salary
	91–720 days

	 	80% of insured base salary

	 	 	Nothing in this paragraph 5.3 shall in any way limit the parties’ freedom to give notice of
termination; once the employment terminated, the Employer shall no longer have the
obligation to make any salary payments but the Employee shall receive the benefits
according to the Pension Scheme, if any.

	 
	6.	 	WORKING HOURS / VACATIONS

	 
	6.1	 	The Employee agrees to exercise his best efforts to successfully and carefully accomplish the duties assigned to him.

	 
	6.2	 	The Employee shall be entitled to 23 working days of paid vacations per calendar
year, in addition to public and bank holidays.

 

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	7.	 	DUTIES OF LOYALTY AND CONFIDENTIALITY

	 
	7.1	 	The Employee shall devote his efforts exclusively to the Employer in furtherance of the
Employer’s interests. Any engagement in additional occupations for remuneration or any
participation in any kind of enterprise requires the written consent of the Employer. This
shall not apply to the usual acquisition of stocks or other shares for investment purposes.
Membership in the board of directors or supervisory board of other companies shall also
require the written approval of the Employer. The employee acknowledges the company policy regarding Board of Director appointments of no more
than two appointments so as to fully ensure balance against outside Board commitments and
Celgene objectives.

	 
	7.2	 	The Employee shall during the period of employment with the Employer and at any
time thereafter, keep secret any confidential information concerning the business,
contractual arrangements, deals, transactions or particular affairs of the Employer or
its affiliates and will not use any such information for his own benefit or the benefit of
others. This obligation shall also exist with respect to any protected data and confidential information of third parties that the Employee gets to know while performing
the obligations under this Agreement.

	 
	7.3	 	Upon termination of this Agreement for any reason, the Employee shall return to the
Employer all files and any company documents concerning the business of the Employer and its affiliates in his possession or open to his access, including all designs,
customer and price lists, printed material, documents, sketches, notes, drafts as well
as copies thereof, regardless whether or not the same are originally furnished by the
Employer or its affiliates.

	 
	8.	 	INVENTIONS

	 
	8.1	 	All intellectual property rights including but not limited to patent rights, design rights,
copyrights and related rights, database rights, trademark rights and chip rights as well
as any rights in know how ensuing from the work performed by the Employee during
the term of his employment (hereinafter the “Intellectual Property Rights”), shall exclusively vest in the Employer. The Employee may not, without the Employer’s written
consent, disclose, multiply, use, manufacture, bring on the market or sell, lease, deliver or otherwise trade, offer, or register the results of his work. Any inventions while
performing the employment contract but not in performance of a contractual obligation
will be compensated appropriately (Art.332 paragraph. 4 CO).

	 
	8.2	 	Insofar as rights that are mentioned in section 8.1 above and are related to the Intellectual Property Rights are not vested in the Employer by operation of law or based on
section 8.1 above, the Employee covenants that he will transfer and, insofar as possible, hereby transfers to the Employer such rights provided, however, that the Employer may renounce such transfer or transfer back to the Employee any such
 Intellectual Property Rights at any time. If a transfer should not be possible under the applicable law, then the Employee shall grant to the Employer a perpetual, transferable,
royalty-free license to use such Intellectual Property Rights.

	 
	8.3	 	The Employer is entitled to transfer the Intellectual Property Rights in full or in part to
any third party. The Employer and such third parties are not obliged to mention the Employee
as the author if they publish any inventions, computer programs or other works. They are free
to make any modifications, translations and/or other adaptations and/or can refrain from making any publications.

 

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	9.	 	DATA PROTECTION

	 
	 	 	With the execution of this Agreement, the Employee consents that the Employer may store,
transfer, adapt and delete all personal data in connection with this employment
relationship. The Employee acknowledges that personal data may be transferred to companies
outside Switzerland affiliated with the Employer, in particular to Celgene Corporation in
the U.S. However all such data transfer shall be guided to be in full compliance with Swiss
Data Protection Law.

	 
	10.	 	RESTRAINT OF COMPETITION

	 
	 	 	The Employee shall not, during the term of his employment and for a 12 months period after
the end of the employment, perform any activity competing with the Employer in specific
subject areas in which the Employee was active or to which he had access during his work
for Celgene.

	 
	 	 	In particular, the Employee agrees:

	 	•	 	not to have, directly or indirectly, any financial or other interest in a business or
company which develops, produces, markets or distributes products substantially similar
to the products of the Employer or its affiliated companies or to render services
similar to those rendered by the Employer or its affiliated companies (a “Competitor”);

	 
	 	•	 	not to accept any part or full time employment in such a Competitor or to act as
consultant, agent or representative of or in any other capacity for such a Competitor;

	 
	 	•	 	not to directly or indirectly establish such a Competitor.

	11.	 	SANCTIONS

	 
	 	 	The Employee understands that a violation of the obligations under article 10 of this
Agreement might cause serious damage to the Employer. In the event the Employee violates an
obligation under article 10 of this Agreement, the Employer shall be entitled to seek
judicial enforcement of such obligation, Furthermore, the Employee agrees to pay to the
Employer an amount of CHF 585,000 as liquidated damages upon each violation of a duty or
obligation under article 10. The payment of the liquidated damages does not relieve the
Employee from the obligations under article 10 of this Agreement. The Employer’s right to
claim damages exceeding the amount of liquidated damages is expressly reserved.

 

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	12.	 	DURATION AND TERMINATION

	 
	12.1	 	This Employment Agreement shall be effective as of November 1, 2008 and last for a fixed
period of two years terminating, without any notice being required, on December 31, 1010.

	 
	13.	 	MISCELLANEOUS

	 
	13.1	 	This Employment Agreement replaces all prior understandings and/or contracts between the parties.

	 
	13.2	 	Amendments and additions to this Agreement including this clause must be in writing
to be effective. This form requirement does not apply to the notice of termination,
which does not require a particular form.

	 
	13.3	 	Should one or several provisions of this Agreement prove invalid, in part or in whole,
such invalid provision(s) shall not affect the validity of the other provisions in this
Agreement. The invalid provision(s) shall be replaced by such valid provision(s) that
best meet(s) the parties’ intention when agreeing on the invalid provision(s).

	 
	14.	 	APPLICABLE LAW

	 
	14.1	 	This Employment Agreement shall be governed by Swiss law.

	 	 	 	 	 	 	 	 	 
	Place

	 	and date
	 	 	 	Place and date	 	 
	 
	 	 	 	 	 	 	 	 
	Summit, NJ 10-7-08	 	 	 	/s/ Sol J. Barer	 	 
	 	 	 	 	 	 	 
	By:

	 	 	 	 	 	Sol J. Barer	 	 
	 
	 	 	 	 	 	 	 	 
	The Employer	 	 	 	The Employee	 	 
	 
	 	 	 	 	 	 	 	 
	Celgene International Sàrl	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	7 Oct 08	 	 	 	/s/ Aart Brouwer	 	 
	 	 	 	 	 	 	 
	By:

	 	 	 	 	 	Aart Brouwer	 	 

 

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