Document:

EX-4.1

 

Exhibit 4.1

EXECUTION VERSION

NANOSPHERE, INC.

SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT

     THIS SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT (this “Agreement”) is made
effective as of April 12, 2006, by and among Nanosphere, Inc., a Delaware corporation (the
“Company”), the Persons listed on Schedule B attached hereto (the “Series B Investing
Stockholders”), the Persons listed on Schedule C attached hereto (the “Series C Investing
Stockholders”), the Persons listed on Schedule C-2 attached hereto (the “Series C-2
Investing Stockholders”) the Persons listed on Schedule D attached hereto (the “Series D
Investing Stockholders” and, together with the Series B Investing Stockholders, the Series C
Investing Stockholders and the Series C-2 Investing Stockholders, the “Investing
Stockholders”), the Persons listed on Schedule E attached hereto (the “Founder
Stockholders”), and the Persons listed on Schedule F attached hereto (the “Minority
Stockholders”). The Investing Stockholders, the Founder Stockholders and the Minority
Stockholders are collectively referred to as the “Stockholders” and individually as a
“Stockholder.” Except as otherwise specified herein, capitalized terms used herein are
defined in Section 8 hereof.

     The Company, the Series B Investing Stockholders, the Series C Investing Stockholders, certain
Founder Stockholders and the Series C-2 Investing Stockholders are parties to that certain Amended
and Restated Stockholders Agreement dated as of June 17, 2005 (the “Prior Agreement”). The
Company, the Series B Investing Stockholders, the Series C Investing Stockholders, the Founder
Stockholders, the Minority Stockholders and the Series C-2 Investing Stockholders are parties to
that certain Amended and Restated Stockholders Agreement (a/k/a the “Other Stockholders Agreement”)
dated as of June 17, 2005 (the “Other Prior Agreement”).

     The Series D Investing Stockholders are purchasing shares of the Company’s Series D Preferred
pursuant to a Series D Preferred Stock and Warrant Purchase Agreement dated as of the date hereof
(the “Series D Purchase Agreement”). The Company and the Stockholder signatories hereto
desire to enter into this Agreement for the purposes, among others, of (i) amending and restating
the Prior Agreement and the Other Prior Agreement, in accordance with the terms of this Agreement
(ii) establishing the composition of the Company’s Board of Directors (the “Board”), (iii)
assuring continuity in the management and ownership of the Company and (iv) limiting the manner and
terms by which the Stockholder Shares may be transferred. The execution and delivery of this
Agreement is a condition to the Series D Investing Stockholders’ purchase of the Series D Preferred
pursuant to the Series D Purchase Agreement.

     For purposes of Section 10 of each of the Prior Agreement and the Other Prior Agreement, the
Stockholder signatories hereto collectively hold in excess of the required percentages of Company
securities, as further specified in each such Section 10, necessary to amend or modify, together
with the Company, the Prior Agreement and the Other Prior Agreement, as the case may be, which
amendments are collectively reflected in this Agreement. Accordingly, all parties to the Prior
Agreement (or any predecessor

1

 

agreement thereto) and the Other Prior Agreement (or any predecessor agreement thereto) shall
be deemed parties to this Agreement as if they were original signatories hereto.

     NOW, THEREFORE, in consideration of the mutual covenants contained herein, and other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties
to this Agreement hereby amend and restate the Prior Agreement and the Other Prior Agreement, as
applicable, and agree as follows:

     1. Board of Directors; Certificate of Incorporation.

     (a) From and after the date hereof, each Stockholder shall vote all shares of Common Stock,
Preferred Stock and any other voting securities of the Company over which such holder has voting
control and shall take all other necessary or desirable actions within such holder’s control
(whether in such holder’s capacity as a stockholder, director, member of a board committee or
officer of the Company or otherwise, and including, without limitation, attendance at meetings in
person or by proxy for purposes of obtaining a quorum and execution of written consents in lieu of
meetings), and the Company shall take all necessary or desirable actions within its control
(including without limitation, calling special board and stockholder meetings), so that:

     (i) subject to applicable provisions of the Certificate of Incorporation, the
authorized number of directors on the Board shall be eight;

     (ii) the following individuals shall be elected to the Board:

     (A) two members designated by LIF (the “LIF Designees”), with
Mark Slezak and Sheli Rosenberg initially serving as such designees;

     (B) two members designated by Bain Capital, with James Nahirny and
Jeffrey Crisan initially serving as such designees as of the date hereof
(the “Bain Designees”);

     (C) one member who shall be the Chief Executive Officer of the
Company, who currently is William P. Moffitt;

     (D) one member of the Company’s management designated by the
Stockholders holding a majority of the Stockholder Shares (on an
as-converted basis) (the “Management Designee”); provided that,
subject to Section 1(a)(v), so long as Chad A. Mirkin (“Mirkin”)
is actively serving the Company as a consultant to the Company or any of
its Subsidiaries and holds a contractual right to serve the Company as a
director, Mirkin (at his option) shall be such designee; and

2

 

     (E) two members who are outside directors (i.e., a person who is not
a member of the Company’s management or an officer or employee of the
Company or its Subsidiaries or an officer, director, employee or
representative of any Stockholder or its Affiliates), designated by a
majority of the other directors of the Board, including in any case the
affirmative vote of at least one Bain Designee and one LIF Designee (the
“Outside Directors”), who shall initially be Andre de Bruin and
Peter Schultz.

     (iii) the composition of the board of directors of each of the Company’s
Subsidiaries (a “Sub Board”) shall be the same as that of the Board;

     (iv) there shall be no executive committee of the Board or any Sub Board or
any other committee of the Board or any Sub Board unless agreed to by the majority
of the Board or any Sub Board, as the case may be, including in any case the
consent of at least one LIF Designee and at least one Bain Designee; provided, that
if any such committee is ever established, it shall be composed of at least two
members, one of whom shall be a Bain Designee, and one of whom shall be an LIF
Designee;

     (v) no director elected pursuant to this Section 1(a) may be removed from
office unless (a) in the case of the LIF Designees designated in accordance with
Section 1(a)(ii)(A), such removal is approved by LIF, (b) in the case of the Bain
Designees designated in accordance with Section 1(a)(ii)(B), such removal is
approved by Bain Capital, (c) in the case of the director designated in accordance
with Section 1(a)(ii)(C), such person is no longer the Chief Executive Officer of
the Company, in which case each Stockholder shall vote to remove such person if
such person has not resigned from the Board, (d) in the case of the Management
Designee designated in accordance with Section 1(a)(ii)D), such removal is approved
by the holders of a majority of the Stockholder Shares (on an as-converted basis)
then outstanding, and (e) in the case of the Outside Directors designated in
accordance with Section 1(a)(ii)(E), such removal is requested by (x) a majority of
the Board, (y) Bain Capital or (z) LIF, in each such case each Stockholder shall
vote to remove such Person if such Person has not resigned from the Board;

     (vi) in the event that any representative designated in accordance with
Section 1(a)(ii) ceases to serve as a member of the Board or a Sub Board during his
term of office, the resulting vacancy on the Board or the Sub Board shall be filled
by a representative selected as provided in Section 1(a)(ii); and

     (vii) the Chairman of the Board (the “Chairman”) shall be elected by the
affirmative vote of a majority of the directors of the Board.

3

 

     (b) The Company shall pay the reasonable out-of-pocket expenses incurred by each director in
connection with attending the meetings of the Board, any Sub Board and any committees thereof. The
Company’s Certificate of Incorporation and bylaws shall provide for indemnification and exculpation
of directors for serving in their capacity as such, to the fullest extent permitted under
applicable law, and the Company shall, upon the reasonable request of any director, negotiate and
enter into an agreement to make more definitive or specific the rights and obligations of the
Company and such director with respect to such indemnification and exculpation.

     (c) The rights of LIF under subsection 1(a)(ii)(A) shall terminate at such time as LIF and its
Permitted Transferees (as defined in subsection 3(f) hereof) hold in the aggregate less than 50% of
the Series C-2 Preferred held by such Persons on the date hereof; it being understood that LIF may
assign its right to designate the LIF Designees hereunder to any Person or group of affiliated
Persons who acquire more than 50% of the Series C-2 Preferred held by LIF on the date hereof. The
rights of Bain Capital under subsection 1(a)(ii)(B) shall terminate at such time as Bain Capital
and its Permitted Transferees (as defined in subsection 3(f) hereof) hold in the aggregate less
than 50% of the Series D Preferred held by such Persons on the date hereof; it being understood
that Bain Capital may assign its right to designate the Bain Designees to any Person or group of
affiliated Persons who acquire more than 50% of the Series D Preferred held by Bain Capital on the
date hereof.

     (d) The provisions of this Section 1 shall terminate automatically and be of no further force
and effect upon the consummation of a Qualified Public Offering.

     (e) If any Stockholder or group of Stockholders fails to designate a representative to fill a
directorship pursuant to the terms of this Section 1 or any Stockholder or group of Stockholders
ceases to have such right hereunder, the election of an individual to such directorship shall be
accomplished in accordance with the Company’s bylaws, Certificate of Incorporation, and applicable
law.

     (f) Each Stockholder agrees to vote all shares of Common Stock, Preferred Stock and any other
voting security of the Company in such a manner as to give full effect to the provisions of the
Certificate of Incorporation of the Company, as the same may be amended from time to time,
including without limitation, the provisions of Section 4B of Article Fourth thereof relating to
the Series C-2 Preferred and Series D Preferred.

     (g) The voting agreements contained herein are coupled with an interest and may not be revoked
during the term of this Agreement.

     (h) The Series A Purchase Agreement, the Series B Purchase Agreement, the Series C Purchase
Agreement, the Original Series C-2 Purchase Agreement and Supplemental Series C-2 Purchase
Agreement are hereby terminated and of no further force and effect. The Stockholders signatory
hereto represent not less than the minimum number of votes necessary to authorize such termination
pursuant to such agreements. The Company and the Stockholders party to each such agreement
severally

4

 

agree to enter into an agreement further evidencing such termination if so requested by any
other party hereto.

     (i) So long as Robert L. Letsinger (“Letsinger” and together with Mirkin, the
“Founders”) is actively serving the Company as a consultant to the Company or any of its
Subsidiaries, Letsinger (at his option) shall be permitted to attend all meetings of the Board in a
nonvoting observer capacity and, in this respect, the Company shall give Letsinger copies of all
notices, minutes, consents and other materials that it provides to its directors; provided,
however, that Letsinger shall agree to hold in confidence and trust all information so provided;
and, provided further, that the Company’s Chairman of the Board reserves the right to withhold any
information and to exclude Letsinger from any meeting or portion thereof if access to such
information or attendance at such meeting could adversely affect the attorney-client privilege
between the Company and its counsel or would result in disclosure of trade secrets to Letsinger.

     (j) So long as Takara Bio Inc. (“Takara”) is a holder of not less than 2.5% of the
outstanding capital stock of the Company, Takara (at its option) shall be permitted to cause its
duly authorized representative to attend all meetings of the Board in a nonvoting observer capacity
and, in this respect, the Company shall give Takara copies of all notices, minutes, consents and
other materials that it provides to its directors; provided, however, that Takara shall agree, and
shall cause its designated representative to agree, to hold in confidence and trust all
confidential, proprietary or secret information so provided; and, provided further, that the
Company’s Chairman of the Board reserves the right to withhold any information and to exclude
Takara’s designated representative from any meeting or portion thereof if access to such
information or attendance at such meeting could adversely affect the attorney-client privilege
between the Company and its counsel or would result in disclosure of trade secrets or other
confidential or proprietary information to Takara or its designated representative.

     (k) So long as Bain Capital holds not less than 30% of the aggregate number of Series D
Preferred originally purchased by Bain Capital pursuant to the Series D Purchase Agreement, Bain
Capital (at its option) shall be permitted to cause its duly authorized representative to attend
all meetings of the Board in a nonvoting observer capacity (the “Bain Observer
Representative”) and, in this respect, the Company shall give Bain Capital copies of all
notices, minutes, consents and other materials that it provides to its directors; provided,
however, that Bain Capital shall cause the Bain Observer Representative to hold in confidence all
confidential, proprietary or secret information so provided; and, provided further, that the
Company, upon the affirmative vote of a majority of directors of the Board, reserves the right to
withhold any information and to exclude the Bain Observer Representative from any meeting or
portion thereof if access to such information or attendance at such meeting could (i) based on the
advice of counsel, adversely affect the attorney-client privilege between the Company and its
counsel or (ii) significantly interfere with the Company’s efforts in connection with a transaction
in which Bain Capital has an interest (other than Bain Capital’s investment in the Company);
provided, however, that in the case of the preceding clause (i), the Bain Observer Representative
will only be excluded if Letsinger, Takara and the LIF Observer Representative are likewise
excluded. The Company shall

5

 

pay the reasonable out-of-pocket expenses incurred by the Bain Observer Representative in
connection with attending meetings of the Board.

     (l) So long as LIF holds not less than 30% of the aggregate number of Series C-2 Preferred
held by such Persons on the date of the Series D Purchase Agreement, LIF (at its option) shall be
permitted to cause its duly authorized representative to attend all meetings of the Board in a
nonvoting observer capacity (the “LIF Observer Representative”) and, in this respect, the Company
shall give LIF copies of all notices, minutes, consents and other materials that it provides to its
directors; provided, however, that LIF shall agree, and shall cause the LIF Observer Representative
to agree, to hold in confidence and trust all confidential, proprietary or secret information so
provided; and, provided further, that the Company, upon the affirmative vote of a majority of
directors of the Board, reserves the right to withhold any information and to exclude the LIF
Observer Representative from any meeting or portion thereof if access to such information or
attendance at such meeting could (i) based on the advice of counsel, adversely affect the
attorney-client privilege between the Company and its counsel or (ii) significantly interfere with
the Company’s efforts in connection with a transaction in which LIF has an interest (other than
LIF’s investment in the Company); provided, however, that in the case of the preceding clause (i),
the LIF Observer Representative will only be excluded if Letsinger, Takara and the Bain Observer
Representative are likewise excluded The Company shall pay reasonable out-of-pocket expenses
incurred by the LIF Observer Representative in connection with attending meetings of the Board.

     2. Representations and Warranties. Each Stockholder represents and warrants that (i)
such Stockholder is the record owner of the number of Stockholder Shares set forth opposite its
name on Schedule A, Schedule B, Schedule C, Schedule C-2, Schedule D, Schedule E or Schedule F
attached hereto, (ii) this Agreement has been duly authorized, executed and delivered by such
Stockholder and constitutes the valid and binding obligation of such Stockholder, enforceable in
accordance with its terms, and (iii) such Stockholder has not granted and is not a party to any
proxy, voting trust or other agreement which is inconsistent with, conflicts with or violates any
provision of this Agreement. No holder of Stockholder Shares shall grant any proxy or become party
to any voting trust or other agreement which is inconsistent with, conflicts with or violates any
provision of this Agreement or prohibits performance by such holder of this Agreement.

     3. Restrictions on Transfer of Stockholder Shares.

     (a) Transfer of Stockholder Shares. No holder of Stockholder Shares shall sell,
transfer, assign, pledge (except as provided below in this Section 3(a)) or otherwise dispose of
(whether with or without consideration and whether voluntarily or involuntarily or by operation of
law) any interest in such holder’s Stockholder Shares (a “Transfer”), except pursuant to
the provisions of this Section 3; provided that in no event shall any Transfer of Stockholder
Shares pursuant to this Section 3 be made (i) to any Competitor, unless such Competitor acquires
all of the outstanding Stockholder Shares or such Transfer is previously approved by the Board,
including the affirmative vote of at least one Bain Designee and one LIF Designee nor (ii) for any
consideration other than

6

 

cash payable upon consummation of such Transfer or in installments over time, and no
Stockholder Shares may be pledged (except for a pledge of Stockholder Shares (A) by a transferee to
secure indebtedness to the transferor thereof hereunder or (B) to the Company or its Subsidiaries
to secure payment of any notes made by any Stockholder to the Company or its Subsidiaries; provided
that, in each case, any such pledge is made expressly subject to the terms, restrictions and
conditions contained in this Agreement). No Stockholder shall consummate any Transfer until 30
days after the later of delivery to the Company and the Other Stockholders (as defined below) of
such Stockholder’s Offer Notice or Sale Notice, unless the parties to the Transfer have been
finally determined pursuant to this Section 3 prior to the expiration of such 30-day period (the
“Election Period”).

     (b) Retention of Shares. In addition to the other restrictions on Transfers set forth
herein, until June 17, 2010, no Founder Stockholders or Minority Stockholder shall Transfer more
than 5% of such holder’s Stockholder Shares held as of the date hereof during any successive one
year period immediately following the date hereof.

     (c) First Offer Right. Subject to Section 3(e), at least 30 days prior to making any
Transfer of any Stockholder Shares, the holder of Stockholder Shares making such Transfer (the
“Transferring Stockholder”) shall deliver a written notice (an “Offer Notice”) to
the Company, the Series C-2 Investing Stockholders, the Series D Investing Stockholders and the
Founder Stockholders but no other Stockholders (the Series C-2 Investing Stockholders, Series D
Investing Stockholders and Founder Stockholders being the “Other Stockholders”), which
shall specify in reasonable detail the proposed number of Stockholder Shares to be transferred, the
proposed terms and conditions of the Transfer and the identity of the transferee(s) (if known).
First, the Company may elect to purchase all of the Stockholder Shares specified in the Offer
Notice at the price and on the terms specified therein by delivering written notice of such
election to the Transferring Stockholder and the Other Stockholders as soon as practical but in any
event within ten days after the delivery of the Offer Notice. If the Company has not elected to
purchase all of the Stockholder Shares specified in the Offer Notice within such ten-day period,
each Other Stockholder (together with the Company if the Other Stockholders electing to purchase
Stockholder Shares consent to the Company’s participation in such purchase) may elect to purchase
all of such holder’s Pro Rata Share (as defined below) of the Stockholder Shares specified in the
Offer Notice at the price and on the terms specified therein by delivering written notice of such
election to the Transferring Stockholder as soon as practical but in no event within 20 days after
delivery of the Offer Notice. Any Stockholder Shares not elected to be purchased by the end of
such 20-day period shall be reoffered for the ten-day period prior to the expiration of the
Election Period by the Transferring Stockholder on a pro rata basis to the Other Stockholders who
have elected to purchase their Pro Rata Share and, if there are any such Stockholder Shares
remaining after such allocation, the Company shall have the right to purchase such remaining
Stockholder Shares. If the Company or any Other Stockholders have elected to purchase Stockholder
Shares from the Transferring Stockholder, the transfer of such shares shall be consummated as soon
as practical after the delivery of the election notice(s) to the Transferring Stockholder, but in
any event within 20 days after the

7

 

expiration of the Election Period. If prior to the expiration of the Election Period the
Company has not elected to purchase all of the Stockholder Shares being offered and the Other
Stockholders have not elected to purchase their respective Pro Rata Shares of the Stockholder
Shares being offered, the Transferring Stockholder may, within 90 days after the expiration of the
Election Period and subject to the provisions of subsection (d) below, transfer the Stockholder
Shares not purchased by the Company or any Other Stockholders to one or more third parties at a
price no less than the price per share specified in the Offer Notice and on other terms no more
favorable to the transferees thereof than offered to the Company and the Other Stockholders in the
Offer Notice. Any Stockholder Shares not transferred within such 90-day period shall be reoffered
to the Company and the Other Stockholders under this Section 3(c) prior to any subsequent Transfer.
Each Other Stockholder’s “Pro Rata Share” shall be based upon such Other Stockholder’s
proportionate ownership of all Common Stock owned or issued upon conversion of the Series C-2
Preferred and Series D Preferred and issuable upon conversion of the Series C-2 Preferred and
Series D Preferred, in either case, owned by Other Stockholders other than the Transferring
Stockholder.

     (d) Participation Rights. Subject to Section 3(e), at least 30 days prior to any
Transfer of Stockholder Shares by a Stockholder or any of its Permitted Transferees (the
“Transferring Stockholder”) (other than a Transfer to the Company or the Other Stockholders
pursuant to Section 3(c)), the Transferring Stockholder shall deliver a written notice (the
“Sale Notice”) to the Company, the Series C-2 Investing Stockholders and the Series D
Investing Stockholders, specifying in reasonable detail the identity of the prospective
transferee(s), the number of shares to be transferred and the terms and conditions of the Transfer
(which notice may be given at the same time as the Offer Notice under Section 3(c)). The Series
C-2 Investing Stockholders and the Series D Investing Stockholders (collectively, the
“Participating Stockholders”) may elect to participate in the contemplated Transfer at the
same price per share and on the same terms by delivering written notice to the Transferring
Stockholder within 30 days after delivery of the Sale Notice. If any Participating Stockholders
have elected to participate in such Transfer, the Transferring Stockholder and such Participating
Stockholders shall be entitled to sell in the contemplated Transfer, at the same price and on the
same terms, a number of Stockholder Shares (determined on an as-converted basis) being transferred
equal to the product of (i) the quotient determined by dividing the percentage of Stockholder
Shares owned by such Person (determined on an as-converted basis) by the aggregate percentage of
Stockholder Shares owned by the Transferring Stockholder (determined on an as-converted basis) and
the Participating Stockholders (determined on an as-converted basis) participating in such sale and
(ii) the number of Stockholder Shares to be sold in the contemplated Transfer.

For example, if the Sale Notice contemplated a sale of 100
Stockholder Shares by the Transferring Stockholder, and if the
Transferring Stockholder at such time owns 30% of all Stockholder
Shares and if one Participating Stockholder elects to participate
and owns 20% of all Stockholder Shares, the Transferring
Stockholder would be entitled to sell 60 shares (30%  ̧ 50% x
100 shares) and the

8

 

Participating Stockholder would be entitled to sell 40 shares (20%
 ̧ 50% x 100 shares).

Each Transferring Stockholder shall use best efforts to obtain the agreement of the prospective
transferee(s) to the participation of the Participating Stockholders in any contemplated Transfer
and to the inclusion of the Stockholder Shares in the completed Transfer, and no Transferring
Stockholder shall transfer any of its Stockholder Shares to any prospective transferee if such
prospective transferee(s) declines to allow the participation of the Participating Stockholders or
the inclusion of any Stockholder Shares. Each Stockholder transferring Stockholder Shares pursuant
to this Section 3(d) shall pay such holder’s pro rata share (based on the number of Stockholder
Shares to be sold) of the expenses incurred by the Stockholders in connection with such transfer
and shall be obligated to join on a pro rata basis (based on the number of Stockholder Shares to be
sold) in any indemnification or other obligations that the Transferring Stockholder agrees to
provide in connection with such transfer (other than any such obligations that relate specifically
to a particular Stockholder such as indemnification with respect to an amount in excess of the net
cash proceeds paid to such holder in connection with such Transfer).

     (e) Drag-Along Rights. In the event that all Founder Stockholders, Series C-2
Investing Stockholders and Series D Investing Stockholders, in each case who holds 5% or more of
the Stockholder Shares, desire to sell (each, a “Selling Stockholder”) all of such
Stockholders’ Stockholder Shares to a bona fide purchaser (a “Third-Party Purchaser”), such
Selling Stockholders shall have the right to require the other Stockholders (the “Non-Selling
Stockholders”) to sell all of their Stockholder Shares to such Third-Party Purchaser in
connection with such sale on the same terms as such Selling Stockholders shall sell such
Stockholder Shares and at a price per share equivalent to the price per share of Stockholder Shares
to be received by such Selling Stockholders in connection with such sale. Such right shall be
exercisable by written notice setting forth the price, terms and conditions of such proposed sale,
given by such Selling Stockholders (a “Buyout Notice”) to each Non-Selling Stockholder.
The Buyout Notice shall state such Selling Stockholders’ proposal to effect the sale of Stockholder
Shares of every party to such Third-Party Purchaser. Each Non-Selling Stockholder agrees that,
upon receipt of a Buyout Notice, such Non-Selling Stockholder shall be obligated to sell all of its
Stockholder Shares for its pro rata portion (determined assuming exchange, conversion or exercise
of all outstanding Stockholder Shares) of the purchase price described in the Buyout Notice and
upon the other terms and conditions of such transaction (and to otherwise take all reasonably
necessary action to cause consummation of the proposed transaction, including voting such
Stockholder Shares in favor of any such transaction). In connection with any transaction, each
Non-Selling Stockholder hereby waives, and agrees to execute upon the reasonable request of the
Selling Stockholders or the Company at any time such further documents evidencing such waiver of,
any dissenters’ rights, appraisal rights or any similar rights it may now have or may subsequently
acquire in respect of Stockholder Shares under any applicable federal, state or other law.

     (f) Permitted Transfers. The restrictions set forth in this Section 3 shall not apply
with respect to any Transfer of Stockholder Shares by any Stockholder (i)

9

 

in the case of an individual, pursuant to applicable laws of descent and distribution or by
will or among such individual’s Family Group, (ii) in the case of an entity, among its Affiliates
not constituting Competitors, (iii) in the case of Mirkin, to his siblings in an aggregate amount
not to exceed 5% of the Stockholder Shares held by Mirkin as of June 17, 2005; provided, that any
Transfers of such Stockholder Shares to Mirkin’s siblings and any subsequent Transfers of such
Stockholder Shares by such transferees shall be counted as having been transferred by Mirkin for
purposes of determining compliance with the restrictions on transfer set forth in Section 3(b)
hereof and shall apply towards such 5% limit, and provided further, that no such transferee shall
have the rights of an Investing Stockholder pursuant to Section 7 hereof, or (iv) in the case of
Letsinger, to Northwestern University in an aggregate amount not to exceed 5% of the Stockholder
Shares held by Letsinger as of June 17, 2005; provided, that any Transfers of such Stockholder
Shares to Northwestern University and any subsequent Transfers of such Stockholder Shares by such
transferee shall be counted as having been transferred by Letsinger for purposes of determining
compliance with the restrictions on transfer set forth in Section 3(b) hereof and shall apply
towards such 5% limit, and provided further, that such transferee shall not have the rights of an
Investing Stockholder pursuant to Section 7 hereof (collectively referred to herein as
“Permitted Transferees”); provided that the restrictions contained in this Section 3 and
in Section 4 shall continue to be applicable to the Stockholder Shares after any such Transfer and
provided further that the transferees of such Stockholder Shares shall have agreed in writing to be
bound by the provisions of this Agreement affecting the Stockholder Shares so transferred.
Notwithstanding the foregoing, no party hereto shall avoid the provisions of this Agreement by
making one or more transfers to one or more Permitted Transferees and then disposing of all or any
portion of such party’s interest in any such Permitted Transferee. “Family Group” means an
individual’s spouse and descendants (whether natural or adopted) and any trust solely for the
benefit of the individual and/or the individual’s spouse and/or descendants.

     (g) Termination of Restrictions. The restrictions set forth in this Section 3 shall
continue with respect to each Stockholder Share until the consummation of a Qualified Public
Offering.

     4. Holdback Agreement. No Stockholder shall effect any sale or distribution of any
Stockholder Shares or of any other capital stock or equity securities of the Company, or any
securities convertible into or exchangeable or exercisable for such stock or securities, during the
seven days prior to and the 180-day period beginning on the effective date of the Company’s initial
underwritten registered public offering of Common Stock (except for (i) sales of securities as part
of such underwritten registered offering (ii) Transfers in accordance with Section 3(f) and (iii)
transactions relating to Common Stock or other securities acquired in open market transactions
after the completion of the initial public offering, if requested by the underwriters managing the
registration; provided, that the Company’s officers, directors and all holders of more than 1% of
the shares of Common Stock (assuming conversion or exercise of all securities convertible into or
exercisable for Common Stock) of the Company enter into similar holdback agreements for the same
period and on the same terms, and provided further

10

 

that any waiver or termination of the prohibitions contained in this Section 4 by the Company
or any underwriter shall apply to each Stockholder.

     5. Legend. Each certificate evidencing Stockholder Shares and each certificate issued
in exchange for or upon the transfer of any Stockholder Shares (if such shares remain Stockholder
Shares after such transfer) shall be stamped or otherwise imprinted with a legend in substantially
the following form:

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A
STOCKHOLDERS AGREEMENT DATED AS OF JANUARY 18, 2000, AMONG THE
ISSUER OF SUCH SECURITIES (THE “COMPANY”) AND CERTAIN OF THE
COMPANY’S STOCKHOLDERS, AS AMENDED AND MODIFIED FROM TIME TO TIME.
A COPY OF SUCH STOCKHOLDERS AGREEMENT SHALL BE FURNISHED WITHOUT
CHARGE BY THE COMPANY TO THE HOLDER HEREOF UPON WRITTEN REQUEST.”

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS AND EXCEPT AS
PERMITTED BY THE STOCKHOLDERS AGREEMENT, MAY NOT BE OFFERED FOR
SALE, SOLD, PLEDGED, OR TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE LAWS OR AN
EXEMPTION FROM REGISTRATION UNDER THE ACT OR APPLICABLE LAWS OR AN
OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT
SUCH REGISTRATION IS NOT REQUIRED.”

The Company shall imprint such legend on certificates evidencing Stockholder Shares outstanding as
of the date hereof, and the Stockholders shall cooperate with the Company in connection therewith.

     6. Transfer. Prior to transferring any Stockholder Shares to any Person, the
transferring holders of Stockholder Shares shall cause the prospective transferee to be bound by
this Agreement and to execute and deliver to the Company and the other holders of Stockholder
Shares a counterpart of this Agreement. No Stockholder shall Transfer any Stockholder Shares
unless such Stockholder Shares have been registered under the Act, or any applicable state
securities laws, or such Stockholder Shares are Transferred pursuant to a valid exemption
therefrom.

11

 

     7. Company Issuances.

     (a) Except for the issuance or sale of securities (i) to directors, officers, employees, or
consultants of the Company or its Subsidiaries pursuant to stock option, stock ownership or other
plans or arrangements approved by the Board, (ii) upon the exercise of all options, warrants or
convertible securities outstanding as of the date hereof, (iii) in connection with the acquisition
of another company or business or a strategic business combination or joint venture approved by the
Board or (iv) pursuant to a public offering registered under the Securities Act, provided, however,
the exclusion in this clause (iv) shall not apply to Bain Capital unless Bain Capital or its
affiliates are offered the right to purchase up to 5% of the shares offered in such an offering at
the offering price per share net of any underwriters commissions or discounts, if the Company
authorizes the issuance or sale of any of its securities (other than Common Stock issued as a
dividend on the outstanding Common Stock) (“Offered Securities”) to any Person, the Company
shall first offer to sell to each Series C-2 Investing Stockholder and Series D Investing
Stockholder (collectively, the “Senior Investing Stockholders”), and not to any other
Stockholders, a portion of such stock or securities equal to the quotient determined by dividing
(1) the number of shares of Common Stock issued upon conversion of the Series C-2 Preferred and the
Series D Preferred and issuable upon conversion of the Series C-2 Preferred and Series D Preferred
immediately prior to the issuance of such Offered Securities held by such Senior Investing
Stockholder by (2) the total number of shares of Common Stock then outstanding, all shares of
Common Stock reserved for issuance under stock option plans approved by the Board, and the number
of shares of Common Stock issuable upon the exercise, exchange or conversion of all outstanding
securities, including, without limitation, the Preferred Stock, exchangeable for or convertible
into shares of Common Stock, but excluding any stock options or warrants for the purchase of Common
Stock or Preferred Stock, immediately prior to the issuance of such Offered Securities. Each
Senior Investing Stockholder shall be entitled to purchase such stock or securities at the most
favorable price and on the most favorable terms as such stock or securities have been or are to be
offered to such Person; provided that if all persons entitled to purchase or receive such stock or
securities are required to also purchase other securities of the Company, the Senior Investing
Stockholders in order to exercise their rights pursuant to this Section shall also purchase the
same strip of securities (on the same terms and conditions) that such other Persons are required to
purchase. The purchase price for all stock and securities offered to the Senior Investing
Stockholders shall be payable in cash or, to the extent otherwise required hereunder, notes issued
by such holders.

     (b) In order to exercise its purchase rights hereunder, a Senior Investing Stockholder holding
less than 5% of the total outstanding Stockholder Shares must within seven (7) business days after
receipt of written notice from the Company (which shall be delivered no less than ten (10) business
days prior to the contemplated closing of such issuance or sale) describing in reasonable detail
the securities being offered, the purchase price thereof, the payment terms and such holder’s
percentage allotment, deliver a written notice to the Company describing its election hereunder.

12

 

     (c) In order to exercise its purchase rights hereunder, a Senior Investing Stockholder holding
5% or more of the total outstanding Stockholder Shares must within fifteen (15) business days after
receipt of written notice from the Company (which shall be delivered no less than thirty (30)
business days prior to the contemplated closing of such issuance or sale) describing in reasonable
detail the securities being offered, the purchase price thereof, the payment terms and such
holder’s percentage allotment, deliver a written notice to the Company describing its election
hereunder.

     (d) Upon the expiration of the offering periods described above, the Company shall be entitled
to sell such securities which the Senior Investing Stockholders have not elected to purchase during
the 75 days following such expiration on terms and conditions no more favorable to the purchasers
thereof than those offered to such holders. Any securities offered or sold by the Company after
such 75-day period must be reoffered to the Senior Investing Stockholders pursuant to the terms of
this section.

     (e) Except as provided in Section 7(a)(iv) above, the rights of the holders of the Senior
Investing Stockholders under this Section 7 shall terminate upon the consummation of a Qualified
Public Offering.

     (f) Notwithstanding the foregoing, the Company may delay offering securities under this
Section 7 to Senior Investing Stockholders holding less than 5% of the total outstanding
Stockholder Shares with respect to any issuance of securities to any other Senior Investing
Stockholder(s); provided, however, that the Board shall have established a mechanism determined to
be fair and reasonable by the Board in its sole discretion, to offer such securities to the
Investing Stockholders within a reasonable time thereafter.

     8. Definitions.

     “Affiliate” means any other Person, directly or indirectly controlling, controlled by
or under common control with such Person and any partner of a Person which is a partnership;
provided, that with respect to Bain Capital, the definition of Affiliate shall include any Person
under common management with Bain Capital.

     “Bain Capital” means, collectively, Bain Capital Venture Fund 2005, L.P., Brookside
Capital Partners and their respective Affiliates.

     “Certificate of Incorporation” means the Company’s Amended and Restated Certificate of
Incorporation, as the same may be amended or modified from time to time.

     “Common Stock” means the Company’s Common Stock, par value $.01 per share.

     “Competitor” means a Person engaging in a business substantially similar to, or
competitive with, the business of the Company, as determined by the Board in its good faith
discretion.

13

 

     “LIF” means, collectively, Lurie Investment Fund, L.L.C. and its Affiliates.

     “Majority Holders” means the Stockholders holding a majority of the aggregate of (i)
Common Stock issued upon conversion of the Series C-2 Preferred and Common Stock issuable upon
conversion of the Series C-2 Preferred then outstanding, (ii) Common Stock issued upon conversion
of the Series D Preferred and Common Stock issuable upon conversion of the Series D Preferred then
outstanding, and (iii) any Common Stock issued with respect to the securities referred to in
clauses (i) and (ii) above by way of stock dividend or stock split or in connection with a
combination of shares, recapitalization, merger, consolidation or other reorganization.

     “Original Series C-2 Purchase Agreement” means that certain Series C-2 Preferred Stock
Purchase Agreement, dated as of September 2, 2004, among the Company and certain Series C-2
Investing Stockholders, as amended from time to time.

     “Person” means an individual, a partnership, a corporation, a limited liability
company, an association, a joint stock company, a trust, a joint venture, an unincorporated
organization and a governmental entity or any other entity or any department, agency or political
subdivision thereof.

     “Preferred Stock” means the Company’s Series B Preferred, Series C Preferred, Series
C-2 Preferred and Series D Preferred.

     “Qualified Public Offering” means a public offering described in paragraph 5H of
Article Fourth of the Company’s Certificate of Incorporation.

     “Securities Act” means the Securities Act of 1933, as amended from time to time.

     “Series B Preferred” means the Company’s Series B Preferred Stock, par value $.01 per
share.

     “Series B Purchase Agreement” means that certain Series B Preferred Stock Purchase
Agreement, dated as of March 13, 2001, among the Company and the Series B Investing Stockholders,
as amended by the Prior Agreement.

     “Series C Preferred” means the Company’s Series C Preferred Stock, par value $.01 per
share.

     “Series C Purchase Agreement” means that certain Series C Preferred Stock Purchase
Agreement, dated as of October 31, 2002, among the Company and the Series C Investing Stockholders,
as amended by the Prior Agreement.

     “Series C-2 Preferred” means the Company’s Series C-2 Preferred Stock, par value $.01
per share.

14

 

     “Series D Preferred” means the Company’s Series D Preferred Stock, par value $.01 per
share.

     “Stockholder Shares” means (i) any Common Stock, Series B Preferred, Series C
Preferred, Series C-2 Preferred or Series D Preferred purchased or otherwise acquired by any
Stockholder, (ii) any Common Stock issued or issuable directly or indirectly upon conversion of the
Series B Preferred, Series C Preferred, Series C-2 Preferred or Series D Preferred, (iii) any
capital stock or equity securities of the Company issued or issuable upon conversion of warrants or
(iv) any Common Stock issued or issuable with respect to the securities referred to in clauses (i)
and (ii) above by way of stock dividend or stock split or in connection with a combination of
shares, recapitalization, merger, consolidation or other reorganization; provided, however, for
purposes of Sections 3(d), Minority Stockholders shall not be considered holders of Stockholder
Shares. For purposes of this Agreement, any Person who holds Series B Preferred, Series C
Preferred, Series C-2 Preferred or Series D Preferred and, except with respect to Sections 3(c),
3(d) and 7(a) hereof, any Person who holds options to acquire shares of Common Stock, shall be
deemed to be the holder of the Stockholder Shares issuable directly or indirectly upon conversion
of the Series B Preferred, Series C Preferred, Series C-2 Preferred or Series D Preferred or the
exercise of such options, whether in connection with the transfer thereof or otherwise and
regardless of any restriction or limitation on the conversion or exercise thereof.

     “Supplemental Series C-2 Purchase Agreement” means that certain Supplemental Series
C-2 Preferred Stock Purchase Agreement, dated as of June 17, 2005, among the Company and certain
Series C-2 Investing Stockholders, as amended from time to time.

     “Subsidiary” means, with respect to any Person, any corporation, limited liability
company, partnership, association or other business entity of which (i) if a corporation, a
majority of the total voting power of shares of stock entitled (without regard to the occurrence of
any contingency) to vote in the election of directors, managers or trustees thereof is at the time
owned or controlled, directly or indirectly, by that Person or one or more of the other
Subsidiaries of that Person or a combination thereof, or (ii) if a limited liability company,
partnership, association or other business entity, a majority of the limited liability company,
partnership or other similar ownership interest thereof is at the time owned or controlled,
directly or indirectly, by any person or one or more Subsidiaries of that Person or a combination
thereof. For purposes hereof, a Person or Persons shall be deemed to have a majority ownership
interest in a limited liability company, partnership, association or other business entity if such
Person or Persons shall be allocated a majority of limited liability company, partnership,
association or other business entity gains or losses or shall be or control the managing director,
managing member or general partners of such limited liability company, partnership, association or
other business entity.

     9. Transfers in Violation of Agreement. Any Transfer or attempted Transfer of any
Stockholder Shares in violation of any provision of this Agreement shall be void, and the Company
shall not record such Transfer on its books or treat any

15

 

purported transferee of such Stockholder Shares as the owner of such shares for any purpose.

     10. Amendment and Waiver. Except as otherwise provided herein, no modification,
amendment or waiver of any provision of this Agreement shall be effective against the Company or
the Stockholders unless such modification, amendment or waiver is approved in writing by the
Company and the Majority Holders; provided that if such modification, amendment or waiver would
adversely affect a holder or group of holders of Stockholder Shares in a manner materially
different than any other holder or group of holders of Stockholder Shares, then such modification,
amendment or waiver will require the written consent of such holder of Stockholder Shares or a
majority of the Stockholder Shares held by such group of holders adversely affected; provided,
further that, (i) so long as LIF and their Permitted Transferees hold at least 50% of the Series
C-2 Preferred outstanding on the date hereof, no modification, amendment or waiver of Sections
1(a)(ii)(A), 1(a)(ii)(E), 1(a)(v) or this Section 10 shall be effective without the written consent
of LIF, and (ii) so long as Bain Capital and its Permitted Transferees hold at least 50% in the
aggregate of the Series D Preferred outstanding on the date hereof, no modification, amendment or
waiver of Sections 1(a)(ii)(B), 1(a)(ii)(E), 1(a)(v) or this Section 10 shall be effective without
the written consent of Bain Capital. The failure of any party to enforce any of the provisions of
this Agreement shall in no way be construed as a waiver of such provisions and shall not affect the
right of such party thereafter to enforce each and every provision of this Agreement in accordance
with its terms.

     11. Confidential Information.

          (a) Non-disclosure. Each Minority Stockholder agrees that, while such Minority
Stockholder is a Stockholder of the Company and at all times thereafter, because of the valuable
nature of the Confidential Information (hereinafter defined), such Minority Stockholder shall use
his best efforts to maintain and protect the secrecy of the Confidential Information and, in
connection therewith, shall not disclose any Confidential Information to any other person or
entity. As used herein, “Confidential Information” shall mean any confidential information
that is used or possessed by the Company.

          (b) Survival; Indemnification. The provisions of this Section 11 shall survive the
termination, expiration or cancellation of this Agreement and, with respect to each Minority
Stockholder, the Transfer of such Minority Stockholder’s interests in the Company. Each Minority
Stockholder agrees to indemnify the Company and each other Stockholder for any loss, damage,
liability, claims and expenses incurred, suffered or sustained by any of them as a result of any
breach by such Minority Stockholder of this Section 11.

     12. Severability. If any provision of this Agreement is held to be prohibited by or
invalid, illegal or unenforceable in any respect under any applicable law by a court of competent
jurisdiction, such invalidity, illegality or unenforceability shall be ineffective only to the
extent of such prohibition, invalidity, illegality or unenforceability

16

 

and shall not affect the validity, legality or enforceability of any other provision of this
Agreement.

     13. Entire Agreement. Except as otherwise expressly set forth herein, this Agreement
and the agreements and instruments referred to herein (except as otherwise terminated herein)
embody the complete agreement and understanding among the parties hereto with respect to the
subject matter hereof and supersede and preempt any prior understandings, agreements or
representations by or among the parties, written or oral, which may have related to the subject
matter hereof in any way, including, without limitation, the Prior Agreement and the Other Prior
Agreement.

     14. Successors and Assigns. Except as otherwise provided herein, this Agreement shall
bind and inure to the benefit of and be enforceable by the Company and its successors and assigns
and the Stockholders and any subsequent holders of Stockholder Shares and the respective successors
and assigns of each of them, so long as they hold Stockholder Shares; provided that any Senior
Investing Stockholder may assign any of its rights to purchase securities from the Company under
Section 7 hereof to such Senior Investing Stockholder’s Permitted Transferees.

     15. Counterparts. This Agreement may be executed in multiple counterparts (any one of
which may be by facsimile), each of which shall be an original and all of which taken together
shall constitute one and the same agreement. At any time after the date hereof, any Person
purchasing Series B Preferred, Series C Preferred, Series C-2 Preferred or Series D Preferred, with
the prior written consent of the Company and the Majority Holders (in each case to be evidenced by
way of a joinder agreement or other instrument satisfactory to the Company), shall (at the request
of the Company and the Majority Holders) become a party to this Agreement by executing a
counterpart to this Agreement and agreeing to be bound by the terms and conditions of this
Agreement as if such Person were an original signatory hereto (which joinder of such additional
Person(s) shall not constitute an amendment, modification or waiver of this Agreement), and such
Person shall be deemed to be an Investing Stockholder for purposes of this Agreement. Unless
otherwise directed by the Majority Holders, the Company shall require any Person who, after the
date of this Agreement, acquires any shares of capital stock of the Company and any employee who
receives restricted stock or other stock-based awards or exercises any stock options, in each case
representing in the aggregate (together with any previously held capital stock of the Company) one
percent (1%) or more of the capital stock of the Company then outstanding (on an as-converted
basis), to become a party to this Agreement as a Stockholder by executing a counterpart signature
page to this Agreement, agreeing to be bound by the terms and conditions of this Agreement as if
such Person were an original signatory hereto (which joinder of such additional Person(s) shall not
constitute an amendment, modification or waiver of this Agreement), and such Person shall be deemed
to be a Stockholder for purposes of this Agreement.

     16. Remedies. The Company and the Stockholders shall be entitled to enforce their
rights under this Agreement specifically, to recover damages by reason of any breach of any
provision of this Agreement and to exercise all other rights existing in

17

 

their favor. The parties hereto agree and acknowledge that money damages would not be an
adequate remedy for any breach of the provisions of this Agreement and that the Company and any
Stockholder may in its sole discretion apply to any court of law or equity of competent
jurisdiction for specific performance and/or injunctive relief (without posting a bond or other
security) in order to enforce or prevent any violation of the provisions of this Agreement.

     17. Notices. Any notice provided for in this Agreement shall be in writing and shall
be either personally delivered or sent by reputable overnight courier service (charges prepaid) to
the Company at the address set forth below and to the Investing Stockholders at the addresses set
forth on the Schedules attached hereto or as indicated by the Company’s records, and to any
subsequent holder of Stockholder Shares subject to this Agreement at such address as indicated by
the Company’s records, or at such address or to the attention of such other person as the recipient
party has specified by prior written notice to the sending party. Notices shall be deemed to have
been given hereunder when delivered personally or one day after deposit with a reputable overnight
courier service.

If to the Company:

Nanosphere, Inc.

4088 Commercial Avenue

Northbrook, Illinois 60062

Attention: President

with a copy to:

Paul, Hastings, Janofsky & Walker LLP

1055 Washington Boulevard

Stamford, CT 06901

Attention: Esteban A. Ferrer

     18. Governing Law. This Agreement shall be governed by and construed in accordance
with the laws of the State of Delaware, without regard to its conflict of laws principles.

     19. Business Days. If any time period for giving notice or taking action hereunder
expires on a day which is a Saturday, Sunday or legal holiday in the state in which the Company’s
chief executive office is located, the time period shall automatically be extended to the business
day immediately following such Saturday, Sunday or legal holiday.

     20. Descriptive Headings. The descriptive headings of this Agreement are inserted for
convenience only and do not constitute a part of this Agreement.

[Remainder of Page Intentionally Left Blank]

18

 

     IN WITNESS WHEREOF, the parties hereto have executed this Second Amended and Restated
Stockholders Agreement on the day and year first above written.

	 	 	 	 	 
	 	COMPANY:

NANOSPHERE, INC.

 	 
	 	By:  	/s/
William P. Moffitt III	 
	 	 	William P. Moffit, President & Chief  	 
	 	 	Executive Officer 	 
	 

	 	 	 	 	 
	 	STOCKHOLDERS:

LFT PARTNERSHIP

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 	ALFA-TECH, LLC

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 	LURIE INVESTMENT FUND, L.L.C.

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 	LURIE INVESTMENTS, INC.

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 	EAGLE CAPITAL MANAGEMENT, LLC

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 	WASK INVESTMENTS, L.L.C.

 	 
	 	By:  	/s/
Mark Slezak	 
	 	 	Mark Slezak, Authorized Signatory 	 
	 	 	 	 
	 

	 	 	 	 	 	 	 
	 	 	ANN AND ROBERT H. LURIE FOUNDATION	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Mark Slezak	 	 
	 

	 	Title	 	Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Laura A. Mondrowski	 	 
	 	 	Laura A. Mondrowski	 	 

	 	 	 	 	 	 	 
	 	 	ALLEN & COMPANY LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Kim Wieland	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Kim Wieland	 	 
	 

	 	Title:	 	CFO	 	 

	 	 	 	 	 	 	 
	 	 	BAIN CAPITAL VENTURE FUND 2005, L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Bain Capital Venture Partners, L.P.
	 	 
	 
	 	 	 	 	 	 
	 	 	Bain Capital Investors, LLC,

its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: James Nahirny

Title: Authorized Person	 	 
	 
	 	 	 	 	 	 
	 	 	BCIP ASSOCIATES III, LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	BCIP Associates III,	 	 
	 

	 	 	 	its sole member and manager	 	 
	 
	 	 	 	 	 	 
	 	 	BCIP ASSOCIATES III-B, LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	BCIP Associates III-B,	 	 
	 

	 	 	 	its sole member and manager	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Bain Capital Investors, LLC	 	 
	 

	 	 	 	their Managing Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 	 	 	 	Name: James Nahirny

Title: Authorized Person	 	 
	 
	 	 	 	 	 	 
	 	 	BROOKSIDE CAPITAL PARTNERS FUND, L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Brookside Capital Investors, L.P.,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Brookside Capital Management, LLC,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ William Pappendick	 	 
	 

	 	 	 	 	 	 
	 	 	Name: William Pappendick	 	 
	 	 	Title:   Managing Director	 	 
	 
	 	 	 	 	 	 
	 	 	RGIP, LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/	 	 
	 

	 	 	 	 	 	 
	 	 	Name:	 	 
	 	 	Managing Member	 	 

[SIGNATURE PAGE TO SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT]

 

 

	 	 	 	 	 	 	 
	 	 	HAL AND RHEA COSKEY REVOCABLE TRUST DATED 12/16/97	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Trustee for the Hal and Rhea Coskey Revocable Trust Dated 12/16/97	 	 
	 

	 	 	 	 	 	 
	 

	 	Name: 	 	Trustee for the Hal and Rhea Coskey Revocable Trust Dated 12/16/97	 	 
	 

	 	Title:	 	Trustee	 	 

	 	 	 	 	 	 	 
	 	 	TAKARA BIO INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Ikunoshin Kato	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Ikunoshin Kato	 	 
	 

	 	Title:	 	CEO	 	 

	 	 	 	 	 	 	 
	 	 	IBRAHIM S. HAWATMEH REVOCABLE LIVING TRUST, DATED 5/24/84	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Trustee for Ibrahim S. Hawatmeh Revocable Living Trust, Dated 5/24/84	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Trustee for Ibrahim S. Hawatmeh Revocable Living Trust, Dated 5/24/84	 	 
	 

	 	Title:	 	Trustee	 	 

	 	 	 	 	 	 	 
	 	 	NEXTGEN ENABLING TECHNOLOGIES FUND, LP	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 

[SIGNATURE PAGE TO SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT]

 

 

	 	 	 	 	 	 	 
	 	 	R CAPITAL II, LTD.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Robert Gephart	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	Robert Gephart	 	 
	 

	 	Title:	 	Vice President	 	 

	 	 	 	 	 
	 	 	 
	 	/s/
Mark Slezak	 
	 	Mark Slezak 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ William T. White III	 
	 	William T. White III 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	/s/ Chad
A. Mirkin	 
	 	Chad A. Mirkin 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	/s/ William
P. Moffitt III	 
	 	William P. Moffitt 	 
	 	 	 
	 

[SIGNATURE PAGE TO SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT]

 

 

	 	 	 	 	 
	 	 	 
	 	/s/ Sheli Z. Rosenberg 	 
	 	Sheli Z. Rosenberg 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Mark Landy 	 
	 	Mark Landy 	 
	 
	 	
/s/ Susanne Landy 	 
	 	Susanne Landy 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Adam N. Mirkin 	 
	 	Adam N. Mirkin 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Rhoderic Peter Mirkin 	 
	 	Rhoderic Peter Mirkin 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Richard Segal 	 
	 	Richard Segal 	 
	 	 	 
	 

[SIGNATURE PAGE TO SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT]

 

 

	 	 	 	 	 
	 	 	 
	 	
/s/ Phillip Van Winkle 	 
	 	Phillip Van Winkle 	 
	 
	 	
/s/ Stephanie Van Winkle 	 
	 	Stephanie Van Winkle 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Robert L. Letsinger 	 
	 	Robert L. Letsinger 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Richard Wickel 	 
	 	Richard Wickel 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Peter J. Stang 	 
	 	Peter J. Stang 	 
	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	
/s/ Steven E. Mather	 
	 	Steven E. Mather      	 
	 	 	 

[SIGNATURE PAGE TO SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT]

 

 

NANOSPHERE, INC.

FIRST AMENDMENT TO

SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT

     THIS FIRST AMENDMENT (this “Amendment”) to the Second Amended and Restated
Stockholders Agreement made effective as of April 12, 2006 (the “Agreement”), is made as of
July 31, 2007, by and among Nanosphere, Inc., a Delaware corporation (the “Company”), and
the parties to the Agreement. Except as otherwise specified herein, capitalized terms used in this
Amendment are defined in the Agreement.

     Whereas, the Company and the Majority Holders desire to amend the definition of “Permitted
Transferees.”

     NOW, THEREFORE, in consideration of the mutual covenants contained herein and other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company
and Majority Holders hereby amend the Agreement as follows:

     1. Amendment of Section 3(f). Clause (i) of the first sentence of Section 3(f) of the
Agreement is hereby amended and restated in its entirety by replacing it with the following:

“(i) in the case of an individual, pursuant to applicable laws of descent
and distribution or by will or among such individual’s Family Group, or to
such individual’s employer or its Affiliates, provided that such employer is
immediately prior thereto a Stockholder hereunder,”.

     2. Full Force and Effect; Counterparts; Delivery. Except as expressly amended hereby,
all terms of the Agreement remain in full force and effect. Any references in the Agreement to
“this Agreement,” “herein,” “hereafter,” “hereto,” “hereof,” and words of similar import shall,
unless the context otherwise requires, mean or refer to the Agreement as amended by this Amendment.
This Amendment may be executed in multiple counterparts (any one of which may be by facsimile),
each of which shall be an original and all of which taken together shall constitute one and the
same agreement. The Company shall deliver a copy of this Amendment to all Stockholders.

[Remainder of Page Intentionally Left Blank]

-1-

 

     IN WITNESS WHEREOF, the parties hereto have executed this First Amendment to Second
Amended and Restated Stockholders Agreement on the day and year first above written.

	 	 	 	 	 
	 	 	THE COMPANY:
	 
	 	 	 	 
	 	 	NANOSPHERE, INC.
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	By:
	 	/s/ J. Roger Moody, Jr.
	 

	 	 	 	 
	 	 	Name: J. Roger Moody, Jr.
	 	 	Title: Chief Financial Officer
	 
	 	 	 	 
	 
	 	 	 	 
	 	 	MAJORITY HOLDERS:
	 
	 	 	 	 
	 	 	LURIE INVESTMENT FUND, L.L.C.
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Mark Slezak
	 

	 	 	 	 
	 	 	Name: Mark Slezak
	 	 	Title:
	 
	 	 	 	 
	 	 	ALFA-TECH, LLC
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Mark Slezak
	 

	 	 	 	 
	 	 	Name: Mark Slezak
	 	 	Title:
	 
	 	 	 	 
	 
	 	 	 	 
	 	 	BROOKSIDE CAPITAL PARTNERS FUND, L.P.
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	By:
	 	/s/
	 

	 	 	 	 
	 	 	Name:
	 	 	Title: Managing Director

 

 

NANOSPHERE, INC.

SECOND AMENDMENT TO THE SECOND AMENDED AND RESTATED

STOCKHOLDERS AGREEMENT

     THIS SECOND AMENDMENT TO THE SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT (this
“Amendment”) is entered into as of October 12, 2007, by and among Nanosphere, Inc., a
Delaware corporation (the “Company”), and the Majority Holders, as that term is defined
herein.

WITNESSETH:

     WHEREAS, the parties hereto, among others, have entered into that certain Second Amended and
Restated Stockholders Agreement, dated as of April 12, 2006 (as amended, supplemented or otherwise
modified prior to the date hereof, the “Existing Agreement”), as amended by the First
Amendment to the Second Amended and Restated Stockholders Agreement
dated as of July 31, 2007;

     WHEREAS, pursuant to Section 8 of the Existing Agreement, the Majority Holders are the
stockholders holding a majority of the aggregate of (i) Common Stock issued upon conversion of the
Series C-2 Preferred and Common Stock issuable upon conversion of the Series C-2 Preferred then
outstanding, (ii) Common Stock issued upon conversion of the Series D Preferred and Common Stock
issuable upon conversion of the Series D Preferred then outstanding, and (iii) any Common Stock
issued with respect to the securities referred to in clauses (i) and (ii) above by way of stock
dividend or stock split or in connection with a combination of shares, recapitalization, merger,
consolidation or other reorganization;

     WHEREAS, pursuant to Section 10 of the Existing Agreement, the Majority Holders and the
Company must approve any amendment to the Existing Agreement in writing;

     WHEREAS, in connection with the Company’s filing of a registration on Form S-1, the Company
and the Majority Holders wish to amend certain terms of the Existing Agreement as set forth herein;

     NOW, THEREFORE, in consideration of the mutual promises contained herein and for other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereby agree to amend the Existing Agreement as follows:

     Section 1. Defined Terms. Capitalized terms used herein and not otherwise defined
herein shall have the same meaning ascribed to them in the Existing Agreement.

     Section 2. Amendment to add a new Section 21. The Existing Agreement is hereby
amended to add the following new Section 21:

 

 

     “Notwithstanding anything contained to the contrary herein, each party hereto agrees that this
Agreement shall automatically terminate (i) following the conversion of the Company’s Preferred
Stock to Common Stock, and (ii) immediately prior to the closing of an underwritten initial public
offering of the Company’s Common Stock pursuant to an effective registration statement under the
Securities Act of 1933, as amended, provided however, that Sections 4 and 11 shall survive any such
termination.”

     Section 3. References to Agreement. All references in the Existing Agreement to
“this Agreement”, “hereunder”, “hereof”, “herein” or words of like import shall mean and be a
reference to the Existing Agreement as amended and modified hereby.

     Section 4. Effectiveness. This Amendment shall become effective as of the date first
written above. The Company shall deliver a copy of this Amendment to all stockholders.

     Section 5. Continuing Validity of Existing Agreement. Except as specifically amended
above, the Existing Agreement shall remain in full force and effect and is hereby ratified and
confirmed.

     Section 6. Governing Law. This Amendment shall be governed by the laws of the State
of Delaware.

     Section 7. Counterparts. This Amendment may be executed simultaneously in any number
of counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

[Remainder of Page Intentionally Left Blank]

 

 

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment to the Second Amended and
Restated Stockholders Agreement on the day and year first above written.

	 	 	 	 	 
	 	 	COMPANY:
	 
	 	 	 	 
	 	 	NANOSPHERE, INC.
	 
	 	 	 	 
	 

	 	By:	 	/s/ William P. Moffitt III
	 

	 	 	 	 
	 

	 	 	 	William P. Moffitt III, President and Chief
	 

	 	 	 	Executive Officer

 

 

	 	 	 	 	 	 	 
	STOCKHOLDERS:
	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Lurie Investment Fund, L.L.C.
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	its Managing Member	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak

Title: Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 
	 	 	 	 	 	 
	 	 	AOQ Trust
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak	 	 
	 

	 	 	 	Title: Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 
	 	 	 	 	 	 
	 	 	Alfa-Tech, LLC
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	its Managing Member	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak	 	 
	 

	 	 	 	Title: Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 
	 	 	 	 	 	 
	 	 	LFT Partnership
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak	 	 
	 

	 	 	 	Title: Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 
	 	 	 	 	 	 
	 	 	Lurie Investments, Inc.
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak	 	 
	 

	 	 	 	Title: Authorized Signatory	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 

 

 

	 	 	 	 	 	 	 
	 	 	Eagle Capital Management
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	its General Partner	 	 
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak	 	 
	 

	 	 	 	Title: Authorized Signatory	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	 	 	 
	 	 	 	 	 
	 	 	William T. White III	 	 
	 	 	Date:   	 	 
	 

	 	 	 	 	 	 
	 

	 	/s/ Mark Slezak	 	 
	 	 	 	 	 
	 	 	Mark Slezak	 	 
	 	 	Date:   10/12/07	 	 
	 

	 	 	 	 	 	 
	 	 	Ann and Robert H. Lurie Foundation
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak

Title: Authorized Signatory	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 
	 

	 	 	 	 	 	 
	 	 	WASK Investments
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: Mark Slezak

Title: Authorized Signatory	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	10/12/07	 	 

 

 

	 	 	 	 	 	 	 
	 	 	Bain Capital Venture Fund 2005, L.P.
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	Bain Capital Venture Partners, L.P.
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	Bain Capital Investors, LLC
	 	 	 	 	its General Partner
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name:   James Nahirny	 	 
	 

	 	 	 	Title:   Managing
Director	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	October 15, 2007	 	 
	 

	 	 	 	 	 	 
	 	 	Brookside Capital Partners Fund, L.P.
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	Brookside Capital Investors, L.P.
	 	 	 	 	its General Partner
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	Brookside Capital Management, LLC
	 	 	 	 	its General Partner
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name:   James Nahirny	 	 
	 

	 	 	 	Title:   Managing
Director	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	October 15, 2007	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	 	 	 
	 	 	BCIP Associates III, LLC
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	BCIP Associates III
	 	 	 	 	its Sole Member and Manager
	 

	 	 	 	 	 	 
	 

	 	By:	 	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name:   James Nahirny	 	 
	 

	 	 	 	Title:   Managing
Director	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	October 15, 2007	 	 

 

 

	 	 	 	 	 	 	 
	 	 	BCIP Associates III-B, LLC
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	BCIP Associates III-B
	 	 	 	 	its Sole Member and Manager
	 

	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 	 	 	 	Bain Capital Investors, LLC
	 	 	 	 	their Managing Partner
	 

	 	 	 	 	 	 
	 

	 	By:	/s/ James Nahirny	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name: James Nahirny	 	 
	 

	 	 	 	Title: Managing Director	 	 
	 

	 	 	 	 	 	 
	 

	 	Date:	 	October 15, 2007EX-10.9

 

Exhibit 10.9

Execution Version

NANOSPHERE, INC.

RESTRICTED STOCK PURCHASE AGREEMENT

          RESTRICTED STOCK PURCHASE AGREEMENT (this “Agreement”), dated as of March 16, 2006, by and between
Nanosphere, Inc., a Delaware corporation (the “Company”), and Mr. William P. Moffitt, an individual resident in the State of Illinois (“Purchaser”).

RECITALS

     A. Purchaser is President, Chief Executive Officer and a director of the Company.

     B. Purchaser and the Company are parties to that certain Employment Agreement, dated as of
July 19, 2004, as amended on the date hereof (the “Employment Agreement”).

     C. The Company desires to sell to Purchaser, and Purchaser desires to purchase, certain shares
of Common Stock, par value $0.01 per share, of the Company (“Common Stock”), as hereinafter
provided, under the Company’s 2000 Equity Incentive Plan, as amended (the “Plan”).

     D. For the purpose of facilitating the purchase of such shares by Purchaser, Purchaser and the
Company, simultaneously with the execution and delivery of this Agreement, are entering into a Loan
and Security Agreement substantially in the form attached as Exhibit A hereto (the “Loan
and Security Agreement”).

AGREEMENT

     NOW, THEREFORE, in consideration of the mutual covenants contained herein, and for such other
good and valuable consideration, the sufficiency and receipt of which are hereby acknowledged, the
parties hereto agree as follows:

     1. Purchase of Shares. The Company hereby agrees to sell to Purchaser, and Purchaser
agrees to purchase, on the date of this Agreement (the “Effective Date”), Eight Million (8,000,000)
shares of Common Stock (the “Shares”) for eighteen cents ($0.18) per share, for an aggregate
purchase price (the “Purchase Price”) of One Million Four Hundred Forty Thousand Dollars
($1,440,000) (the “Transaction”). Payment for the Shares in the amount of the Purchase Price shall
be made to the Company upon execution of this Agreement, by the execution and delivery by Purchaser
of the Promissory Note substantially in the form attached to the Loan and Security Agreement as
Schedule 1 thereto (the “Promissory Note”). All Shares issued hereunder shall be deemed
issued to Purchaser as fully paid and nonassessable shares, and Purchaser shall have all rights of
a stockholder with respect thereto, including the right to vote, receive dividends (including stock
dividends), participate in stock splits or other recapitalizations, and exchange such

 

 

shares in a merger, consolidation or other reorganization. The Company shall be responsible
for and shall pay any and all applicable stock transfer taxes in connection with the Transaction.
(The Company does not undertake under this Agreement to pay any other tax, including, without
limitation, any tax incurred by Purchaser in connection with the payment of any future dividends
paid by the Company on the Shares.)

     2. Closing. The closing of the Transaction shall occur contemporaneously with the
execution and delivery of this Agreement. On the Effective Date, Purchaser shall deliver to the
Company the Promissory Note duly executed, and the Company shall deliver to Purchaser one or more
certificates representing the Shares, free and clear of all liens and encumbrances of any kind,
except those required by applicable securities laws, this Agreement, the Loan and Security
Agreement and the Promissory Note, registered in such names and in such denominations as Purchaser
shall require.

     3. Securities Law Compliance.

          (a) Purchaser Representations and Warranties. Purchaser hereby represents to,
acknowledges to and promises (as applicable) the Company as follows:

     (i) the Shares have not been registered under the Securities Act of 1933, as
amended (the “Securities Act”), and are being issued to Purchaser in reliance upon one or
more exemptions from the registration requirements of the Securities Act, including,
without limitation, the exemption from such registration provided by Rule 701 promulgated
under the Securities Act for stock issuances under compensatory benefit plans such as the
Plan;

     (ii) no authority of the United States or any state of the United States has
made any finding or determination as to the fairness of an investment in the Common Stock
and no such authority has recommended or endorsed or will recommend or endorse the
Transaction;

     (iii) the Shares are restricted securities and may not be resold or
transferred unless the Shares are first registered under the Securities Act or unless an
exemption from such registration is available;

     (iv) Purchaser is acquiring the Shares for Purchaser’s own account, for
investment and not with a view to resale or “distribution” (as such term is defined in the
Securities Act), except in compliance with the Securities Act; and

     (v) Purchaser is an “Accredited Investor” as defined in Rule 501 promulgated
under the Securities Act, by reason of the fact that Purchaser meets the conditions set
forth in subparagraphs a(4), a(5) or a(6) thereof.

Purchaser acknowledges that the representations, acknowledgements and promises contained in this
Section 3(a) may be relied upon by Company as a basis for the exemption of the issuance of the
Shares from the registration requirements of the

 - 2 - 

 

 Securities Act and applicable state securities laws and shall survive the consummation of the
Transaction.

          (b) Legends. Each certificate evidencing the Shares shall bear the following
legend, unless, in the opinion of counsel reasonably satisfactory to the Company, such Shares
represented by such certificate are no longer subject to such restrictions imposed under
applicable securities laws, in which case such legend shall be removed from such certificate:

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY APPLICABLE STATE SECURITIES
LAW. ANY TRANSFER OF SUCH SECURITIES WILL BE INVALID UNLESS A REGISTRATION
STATEMENT UNDER THE ACT IS IN EFFECT AS TO SUCH TRANSFER OR IN THE OPINION OF
COUNSEL REASONABLY SATISFACTORY TO THE COMPANY SUCH REGISTRATION IS UNNECESSARY IN
ORDER FOR SUCH TRANSFER TO COMPLY WITH THE ACT.”

     4. No Effect on Employment Agreement. This Agreement and the Transaction are not
intended to, and do not, modify, supplement or in any way affect the terms of the Employment
Agreement. By entering into this Agreement, or into the Loan and Security Agreement, the Company
does not promise or guarantee Purchaser’s employment by the Company for any period of time.

     5. Company Repurchase of Shares. Upon the occurrence of a Triggering Event (as
defined below), the Purchaser shall promptly sell to the Company, and the Company shall promptly
purchase from the Purchaser, for a price of eighteen cents ($0.18) per Share, such number of Shares
as set forth in the following schedule:

     (i) if the Triggering Event occurs prior to July 19, 2006, four million
(4,000,000) Shares;

     (ii) if the Triggering Event occurs on or after July 19, 2006, but prior to
July 19, 2007, two million (2,000,000) Shares; and

     (iii) if the Triggering Event occurs on or after July 19, 2007, no Shares.

For the purposes of this Section 5, “Triggering Event” means any of the following: (i) Purchaser’s
employment by the Company during the term of the Employment Agreement shall have been terminated by
the Company for “Cause” (as defined in the Employment Agreement); or (ii) Purchaser’s employment by
the Company during the term of the Employment Agreement shall have been terminated by Purchaser
without “Good Reason” (as defined in the Employment Agreement).

 - 3 - 

 

     6. Stockholders’ Agreements. Purchaser shall sign and become a party to, as of the
Effective Date, each of (i) that certain Amended and Restated Stockholders Agreement by and among
the Company and certain stockholders of the Company, dated as of June 17, 2005 and (ii) that
certain Amended and Restated Stockholders Agreement by and among the Company and certain other
stockholders of the Company (a/k/a the “Other Stockholders Agreement”), dated as of June 17, 2005,
in each case, on such terms and conditions as set forth therein and in such capacity as a
stockholder (as contemplated therein) as the Company may approve.

     7. General Provisions.

          (a) Governing Law. This Agreement shall be construed, interpreted and governed by
the laws of the State of Illinois, without regard to the conflicts of law rules thereof.

          (b) Notices. All notices made pursuant to this Agreement shall be in writing and
shall be sent by prepaid certified mail, return receipt requested, or by recognized air courier
service, addressed as follows:

(i) If to the Company to:

Mr. Stephen G. Wasko

Chief Financial Officer

Nanosphere, Inc.

4088 Commercial Avenue

Northbrook, Illinois 60062

copy to:

Paul, Hastings, Janofsky & Walker LLP

1055 Washington Boulevard

Stamford, Connecticut 06901

Attention: Esteban A. Ferrer, Esq.

(ii) If to Executive to:

Mr. William P. Moffitt

942 Pine Tree Lane

Winnetka, Illinois 60093

or to such other addresses as may hereafter be specified by notice in writing by either of the
parties hereto, and shall be deemed given three (3) business days after the date so mailed or
sent.

          (c) Severability. If any provision of this Agreement is determined to be invalid,
illegal or unenforceable, the remaining provisions of this Agreement shall

 - 4 - 

 

           remain in full force and effect, so long as the essential terms and conditions of this
Agreement for each party hereto remain valid, binding, and enforceable.

          (d) Counterparts. This Agreement may be executed in counterparts, each of which
shall be deemed an original but all of which together shall constitute one and the same
instrument.

[Signature Page Follows.]

 - 5 - 

 

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above.

	 	 	 	 	 	 	 
	 
	 	 	/s/ William P. Moffitt
III	 	 
	 	 	 	 	 
	 	 	MR. WILLIAM P. MOFFITT	 	 
	 
	 	 	 	 	 	 
	 	 	NANOSPHERE, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	/s/ Mark Slezak	 	 
	 

	 	 	 	 

	 	 
	 

	 	Name:
	 	Mr. Mark Slezak	 	 
	 

	 	Title:
	 	Chairman of the Board of Directors	 	 

[Signature
Page to Restricted Stock Purchase Agreement]

   

 

Execution Version

Promissory Note 

ONE MILLION FOUR HUNDRED FORTY THOUSAND DOLLARS ($1,440,000)

March 16, 2006

Northbrook, Illinois

     1. Loan. For value received, the receipt and sufficiency of which are hereby
acknowledged, Mr. William P. Moffitt, an individual resident in the State of Illinois (“Borrower”),
hereby promises to pay to the order of Nanosphere, Inc., a Delaware corporation (“Lender”), on the
earlier of (i) the seventh anniversary of the date hereof, (ii) immediately prior to the completion
of the Lender’s first underwritten public offering of its securities registered under the
Securities Act of 1933, as amended, and (iii) immediately prior to the consummation of a Change in
Control (as defined in the Employment Agreement)(the “Maturity Date”), One Million Four Hundred
Forty Thousand Dollars ($1,440,000) (the “Loan”), together with interest on the unpaid balance of
such amount from the date of this Promissory Note, as provided herein. This Promissory Note is the
Promissory Note issued under that certain Loan and Security Agreement by and between Borrower and
Lender, of even date herewith (said agreement, as the same may be amended, restated or supplemented
from time to time, being herein called the “Agreement”), to which a reference is made for a
statement of all of the terms and conditions of the Loan evidenced hereby. Capitalized terms not
defined in this Promissory Note shall have the respective meanings assigned to them in the
Agreement. This Promissory Note is secured by the Agreement and the Collateral, and is entitled to
the benefit of the rights and security provided thereby.

2. Term and Prepayment

          (a) Term. On the Maturity Date, Borrower shall pay to Lender in full, in cash, all
outstanding principal and accrued but unpaid interest on the Loan.

          (b) Prepayment. Borrower shall have the right, at any time, upon seven (7) Business
Days’ prior written notice to Lender, to prepay all or a portion of the Loan (and any accrued by
unpaid interest thereon), without penalty.

     3. Interest 

          (a) Rate. Borrower shall pay interest to Lender on the outstanding portion of the Loan
at a rate per annum equal to four and fifty-one one-hundredths percent (4.51%). All computations
of interest shall be made by Lender on the basis of a three-hundred-and-sixty-day
(360) year.

          (b) Payment. Interest shall be payable by Borrower in immediately available United
States Dollars, in arrears for the preceding year on each anniversary of the date hereof (or the
next succeeding Business Day, if such day is not a Business Day).

A-1

 

     4. Events of Default. An “Event of Default” shall be deemed to have occurred for
the purposes of this Promissory Note, upon the occurrence of any of the following events:

	 	(i)	 	Non-Payment. Borrower shall have failed for thirty (30) days following receipt of
notice of such delinquency from Lender to make to Lender any payment due under this Promissory
Note.
	 
	 	(ii)	 	Involuntary Termination For Cause. Borrower’s employment by Lender during the
term of the Employment Agreement shall have been terminated by Lender for “Cause” (as defined in
the Employment Agreement); or
	 
	 	(iii)	 	Voluntary Termination Without Good Reason. Borrower’s employment
by Lender during the term of the Employment Agreement shall have been terminated by
Borrower without “Good Reason” (as defined in the Employment Agreement).

     5. Remedies. Upon the occurrence of any one or more of the Events of Default
specified in this Promissory Note, all amounts then remaining unpaid on this Promissory Note may
be declared to be immediately due and payable, all as provided in the Agreement and hereunder.

     6. Waivers

          (a) Defenses. To the fullest extent permitted by applicable law, Borrower waives:
(a) presentment, demand and protest, and notice of presentment, dishonor, intent to
accelerate, acceleration, protest, default, nonpayment, maturity, release, compromise, settlement,
extension or renewal of any or all of the Loan, the Agreement or this Promissory Note; (b) all
rights to notice and a hearing prior to Lender’s taking possession or control of, or to Lender’s
replevy, attachment or levy upon, the Collateral or any bond or security that might be required by
any court prior to allowing Lender to exercise any of its remedies; and (c) the benefit of all
valuation, appraisal and exemption laws.

          (b) No Jury Trial. Borrower hereby waives the right to trial by jury in any action or
proceeding under the Agreement or under this Promissory Note.

     7. Governing Law. This Promissory Note shall be construed, interpreted and governed by
the laws of the State of Illinois, without regard to the conflicts of law rules thereof.

[Signature page follows.]

A-2

 

     THE UNDERSIGNED, INTENDING TO BE LEGALLY BOUND, has executed this Promissory Note
as of the date first set forth above.

WITNESS

	 	 	 
	/s/

	 	/s/ WILLIAM P. MOFFITT
	 

	 	 
	Name:

	 	MR. WILLIAM P. MOFFITT

[Signature Page to Promissory Note]

 

 

Schedule 2 

Stock Certificates

	 	 	 
	Certificate Number	 	Number of Shares
	24
	 	8,000,000

B-1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00130-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00130-of-00352.parquet"}]]