Document:

EX-10.18

 Exhibit 10.18 

AMENDMENT NO. 1 TO LEASE 

This Amendment No. 1 to Lease (the “Amendment”) is dated for reference purposes as May 26, 2011, and is made
between New Goodyear Ltd., a California limited partnership (hereinafter referred to as “Landlord”) and IsoTis OrthoBiologics, Inc., a Washington corporation (hereinafter referred to as “Tenant”)
(collectively, the “Parties”). 
 RECITALS 

 

	A.	Landlord and Tenant entered into that certain Amended and Restated Lease dated the 23rd day of February 2006 (the “Lease”), covering approximately
43,538 square feet of space commonly known as 2 Goodyear, Unit A, Irvine, California 92618 (the “Property”). 

  

	B.	Whereas, Landlord and Tenant now desire to amend the Lease by extending Tenant’s Lease Term, and by making certain other changes pursuant to the terms and conditions hereinafter set forth. 

THEREFORE, the Parties agree to amend the Lease as follows: 
  

	1.	LEASE TERM: The Lease Term set forth in Section 1.05 is hereby amended such that: The Lease Term is extended for a period of sixty-three (63) months, to and including October 31, 2016
(“Extension Period”). 

  

	2.	BASE RENT: Section 1.12(a) is hereby amended as follows: The monthly Base Rent for the Property during the Extension Period shall be as follows: 

 

					
	 Rental Adjustment Date:
	  	Monthly Base Rent:	 
	 August 1, 2011 through July 31, 2012
	  	$	37,007.00, NNN	  
	 August 1, 2012 through July 31, 2013
	  	$	38,117.00, NNN	  
	 August 1, 2013 through July 31, 2014
	  	$	39,261.00, NNN	  
	 August 1, 2014 through July 31, 2015
	  	$	40,439.00, NNN	  
	 August 1, 2015 through July 31, 2016
	  	$	41,652.00, NNN	  
	 August 1, 2016 through October 31, 2016
	  	$	42,902.00, NNN	  

  

	3.	ABATED RENT: Tenant shall receive three (3) months of abated rent, specifically months one (1), two (2), and three (3) of the Extension Period (the “Rental Abatement Months”).
Tenant will be subject to all the provisions of the Lease excepting that Tenant shall not be required to pay Base Rent or Tenant’s pro rata share of expenses, per paragraph 1.12(b) of the Lease for the Rental Abatement Months.

  

	4.	LIMITATION ON CERTAIN COSTS: Paragraph 31 of Rider No. 1 attached to the Lease is hereby amended and restated in its entirety to read as follows: 

“31. Limitation on Certain Costs: 

Notwithstanding anything to the contrary contained in the Lease, the aggregate amount that Tenant shall be obligated to reimburse pursuant to,
Section 4.04(b) (insurance) and Section 4.05 (common area costs, which common area costs shall include Reserves) 

 IsoTis OrthoBiologics, Inc. 

Amendment No. 1 to Lease 
 May 26, 2011 

 Page 
 2
 
  

 
during any calendar year of the Lease Term shall not exceed an amount equal to $62,695 ($0.12/sf/mo.) for calendar year 2011 increased by five percent each following year, compounded annually.
Thus, if Tenant’s annualized cost for calendar year 2011 were $62,695, it would not be required to reimburse an aggregate in excess of $65,830 for calendar year 2012, or $69,122 for calendar year 2013. Notwithstanding the foregoing, the
limitations set forth in this Paragraph 31 shall terminate immediately upon any transfer, other than to Tenant’s Affiliate, of Tenant’s interest in the Lease or the Property, regardless of whether Landlord consents to such
transfer.” 
  

	5.	TENANT IMPROVEMENTS: Landlord shall provide Tenant a Tenant Improvement Allowance equal to Two Hundred Thousand and 00/100 Dollars ($200,000.00) (the “Allowance”) to be used for expansion of the
existing clean room, construction of additional manufacturing areas, and for general refurbishment (the “Tenant’s Work”). Tenant shall be solely responsible for the completion of the Tenant’s Work. Prior to commencing
construction of the Tenant’s Work, Tenant shall provide Landlord with design drawings and specifications for Landlord’s approval which shall not be unreasonably withheld. Tenant’s performance of the Tenant’s Work shall conform to
all the terms and conditions stated in Section 6.05 “Alterations, Additions and improvements,” including but not limited to, the requirement that Tenant receive all required governmental and municipal permits and approvals prior to
and during construction of such improvements. Landlord’s consent to such improvements, or Landlord’s approval of the plans, specifications, working drawings and construction for such improvements shall create no responsibility or liability
on the part of Landlord for their completeness, design sufficiency, quality of workmanship or compliance with all laws, rules, and regulations of governmental and quasi-governmental agencies. 

The Allowance will be paid to Tenant in one lump sum upon completion of all of the following: a) Tenant’s receipt of a building
permit; b) Tenant’s construction of the Tenant’s Work, per city approved plans and specifications; c) Tenant’s receipt of a Certificate of Occupancy or other municipal sign-off or approval; d) copies of all as-built drawings and specifications and copies of any applicable warranties have been provided to Landlord and e) Tenant has fully paid for all of the work and has furnished Landlord with paid invoices and
unconditional contractor, subcontractor and supplier releases evidencing such. Landlord shall have the right to inspect the improvements to verify their completion and inspect the quality of those improvements prior to the release of Allowance. Any
unused portion of the Allowance shall be credited to Tenant in the form of rent abatement, commencing with the month the improvements are complete and ending when the credit is exhausted. 

 

	6.	OPTION TO EXTEND TERM AMENDMENT RIDER: Tenant shall have two (2) five (5) year options to extend pursuant to the Option to Extend Term Amendment Rider attached to and made a part of this
Amendment No. 1 to Lease. 

  

	7.	HVAC UNITS: No later than July 31, 2011, the fourteen (14) existing rooftop HVAC units identified in Exhibit “A” shall be replaced by Landlord, at Landlord’s sole cost and
expense, with new units of equivalent or superior specifications. All warranties for the new rooftop HVAC units shall inure to the benefit of Tenant. 

 IsoTis OrthoBiologics, Inc. 

Amendment No. 1 to Lease 
 May 26, 2011 

 Page 
 3
 
  

	8.	ROOF: No later than July 31, 2011, Landlord shall install a four (4) ply build up roof system over the existing roof. This installation will be covered under a ten (10) year
manufacturer’s warranty. 

  

	9.	SECURITY DEPOSIT: The existing Security Deposit per Section 1.10 of the Lease shall remain $43,538.00 for the Extension Period. 

 

	10.	BINDING FORCE: Submission of this Amendment is not an offer to lease or amend the Lease. This Amendment shall become binding upon Landlord and Tenant only when the Amendment is fully executed and delivered
by Landlord. In the event Landlord does not execute and deliver the Amendment, then the Amendment shall be void and of no force or effect. 

  

	11.	RATIFICATION OF THE LEASE: The terms of the Lease are amended to reflect the changes set forth above. In all other respects the terms of the Lease shall be in full force and effect. In the event of any
conflict between this Amendment and the Lease, the terms of this Amendment shall be deemed controlling. 

  

	12.	CAPITALIZED TERMS: Except as otherwise expressly provided herein, the capitalized terms and phrases in this Amendment shall have the meanings as are given such terms in the Lease. 

 

	13.	AUTHORITY: If Tenant is a corporation, trust, general or limited partnership, each individual executing this Amendment on behalf of such entity represents and warrants that he or she is duly authorized to
execute and deliver this Amendment on behalf of said entity. 

  

	14.	CONFIDENTIALITY: It is understood and agreed by Tenant, that any rent or other concessions made by Landlord as specified herein are confidential. Tenant shall not disclose any of the terms of this
Amendment to any third party, and shall use all reasonable efforts to preserve the confidentiality of the terms of this Amendment. Tenant agrees that the information contained herein constitutes unique, and valuable business information of Landlord,
and that disclosure of such information would cause Landlord serious and irreparable harm. Tenant shall indemnify Landlord against all claims, liabilities, damages, losses, and costs of whatsoever kind or nature, including attorney’s fees and
court costs, arising out of, or resulting from Tenant’s breach or violation of this Paragraph. 

 IsoTis OrthoBiologics, Inc. 

Amendment No. 1 to Lease 
 May 26, 2011 

 Page 
 4
 
  

									
	 LANDLORD:
 NEW
GOODYEAR LTD,
 a California limited partnership
				 TENANT:
 ISOTIS
ORTHOBIOLOGICS, INC.,
 a Washington corporation

					
	By:		/s/    Jon Monkarsh				By:		/s/    Stuart M. Essig
			Signature						Signature
					
	By:		Jon Monkarsh				By:		Stuart M. Essig
			Print name						Print Name
					
	By:		Authorized Representative				Its:		President & CEO
			Title						Title
					
	Date:  		6-9-11				Date:  		5/26/11
									

 OPTION TO EXTEND TERM AMENDMENT RIDER 

This Rider is attached to and made part of that certain Amendment No. 1 to Lease (the “Amendment”) dated May 26, 2011 between,
New Goodyear Ltd., a California limited partnership as Landlord, and IsoTis OrthoBiologics, Inc., a Washington corporation as Tenant, covering the Property commonly known as 2 Goodyear, Unit A, Irvine, California
92618, (the “Property”). The terms used herein shall have the same definitions as set forth in the Lease. The provisions of this Rider shall supersede any inconsistent or conflicting provisions of the Lease. 

 

	A.	Option(s) to Extend Term. 

  

	 	1.	Grant of Option. 

 Landlord hereby grants to Tenant two (2) options (the
“Option”) to extend the Lease Term for an additional term of five (5) years each (the “Extension Period”), on the same terms and conditions as set forth in the Lease, but at an increased rent as set forth below. Each Option
shall be exercised only by written notice delivered to Landlord at least one hundred twenty (120) days, but not more than 360 days before the expiration of the Lease Term or the Extension Period respectively. If Tenant fails to deliver to
Landlord written notice of exercise of an Option within the prescribed time period, such Option and any succeeding Options shall lapse, and there shall be no further right to extend the Lease Term. Each Option shall be exercisable by Tenant on the
express conditions that (a) at the time of the exercise, and at all times prior to the commencement of such Extension, Tenant shall not be in default under any of the provisions of the Lease beyond all applicable cure periods and
(b) Tenant has not been ten (10) or more days late in the payment of rent more than a total of two (2) times during the preceding 12 month period. 
  

	 	2.	Personal Options. 

 The Option(s) are personal to the Tenant named in Section 1.03
of the Lease or any Tenant’s Affiliate described in Section 9.02 of the Lease. If Tenant subleases any portion of the Property or assigns or otherwise transfers any interest under the Lease to any entity other than a Tenant Affiliate prior
to the exercise of an Option (whether with or without Landlord’s consent), such Option and any succeeding Options shall lapse. If Tenant subleases any portion of the Property or assigns or otherwise transfers any interest of Tenant under the
Lease to any entity other than a Tenant Affiliate after the exercise of an Option but prior to the commencement of the respective Extension (whether with or without Landlord’s consent), such Option and any succeeding Options shall lapse and the
Lease Term shall expire as if such Option were not exercised. If Tenant subleases any portion of the Property or assigns or otherwise transfers any interest of Tenant under the Lease in accordance with Article 9 of the Lease after the exercise
of an Option and after the commencement of the Extension related to such Option, then the term of the Lease shall expire upon the expiration of the Extension during which such sublease or transfer occurred and only the succeeding Options shall
lapse. 

	B.	Calculation of Rent. 

 The Base Rent during the Extension(s)shall be determined by one or
a combination of the following methods (INDICATE METHOD UPON EXECUTION OF THE LEASE): 
  

	 	1.	[Reserved] 

  

	 	2.	Fair Rental Value Adjustment (Section B.2, below) as determined by broker 

 Rental
Adjustment Date: November 1, 2016, November 1, 2021 
 On the Rental Adjustment Date, the Base Rent shall be adjusted to the
“Fair Rental Value” of the Property. Three months prior to the Rental Adjustment Date, the parties shall attempt to agree upon what the new Fair Rental Value will be on the adjustment date. If agreement cannot be reached within fifteen
days, then both Landlord and Tenant shall each immediately make a reasonable determination of the Fair Rental Value of the Property and submit such determination, in writing, for appraisal in accordance with the following provisions: 

(i) Within 15 days thereafter, Landlord and Tenant shall each select an appraiser of their choice. The two appraisers so
appointed shall immediately select a third mutually acceptable appraiser to act as a third appraiser. 
 (ii) The
3 appraisers shall within 15 days of their appointment of the third appraiser reach a decision as to what the actual Fair Rental Value for the Property is, and whether Landlord’s or Tenant’s submitted Fair Rental Value is the
closest thereto. The decision of a majority of the appraisers shall be binding on the parties. The submitted Fair Rental Value that is determined to be closest to the actual Fair Rental Value shall thereafter be used by the parties. 

(iii) If either of the parties fails to appoint an appraiser within the specified 15 days, the appraiser timely appointed
by one of them shall reach a decision on his or her own, and said decision shall be binding on the parties. 
 (iv) The
entire cost of such appraisal(s) shall be paid equally by the party whose submitted Fair Rental Value is not selected (i.e., the one that is not the closest to the actual Fair Rental Value). 

 

	 	3.	[Reserved] 

									
	 LANDLORD:
 NEW
GOODYEAR LTD,
 a California limited partnership
				 TENANT:
 ISOTIS
ORTHOBIOLOGICS, INC.,
 a Washington corporation

					
	By:		/s/    Jon Monkarsh				By:		/s/    Stuart M. Essig
			Signature						Signature
					
	By:		Jon Monkarsh				By:		Stuart M. Essig
			Print name						Print Name
					
	By:		Authorized Representative				Its:		President & CEO
			Title						Title
					
	Date:  		6-9-11				Date:  		5/26/11EX-10.19

 Exhibit 10.19 

SECOND AMENDMENT TO INDUSTRIAL REAL ESTATE LEASE 

This Second Amendment to Industrial Real Estate Lease (this “Amendment”) is made and entered into this 14th of May, 2013, by and between KTR OC I LLC, a Delaware limited liability company (“Landlord”) and ISOTIS ORTHOBIOLOGICS, INC., a Washington corporation
(“Tenant”). 
 RECITALS 

WHEREAS, New Goodyear, Ltd. (the predecessor-in-interest to Landlord) and Tenant entered into that certain Industrial Real Estate Lease
dated as of February 23, 2006 (“Original Lease”), as amended by that certain Rider No. 1 dated as of February 23, 2006 (“Rider No. 1”), by that certain Rider No. 2 dated as of
February 15, 2006 (“Rider No. 2”), and by that certain Amendment No. 1 to Lease dated as of May 26, 2011 (“Amendment No. 1”; the Original Lease, as amended by the aforementioned riders and
amendments is hereinafter referred to as the “Amended Lease”), with respect to certain premises consisting of approximately 43,538 square feet (the “Original Premises”), in the building commonly known as
2 Goodyear, Irvine, California (the “Building”); and 
 WHEREAS, capitalized terms used and not
otherwise defined herein shall have the meanings respectively ascribed to them in the Amended Lease; and 
 WHEREAS, the
parties wish to amend the Amended Lease as set forth in this Amendment. 
 NOW, THEREFORE, for good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby affirm the foregoing recitals and agree as follows: 

1. Recitals. The recitals set forth above are hereby incorporated into the body of this Amendment as if fully restated herein.
From and after the date hereof, references to the “Lease” (including, without limitation, any and all references contained in this Amendment) shall mean the Amended Lease as amended by this Amendment. 

2. Expansion of Property. From and after May 1, 2013 (the “Expansion Date”), the Property shall be
expanded to include that certain space located in the Building consisting of approximately 26,462 square feet of space (the “Expansion Premises”), such that, from and after the Expansion Date, (a) Landlord shall lease to
Tenant, and Tenant shall lease from Landlord, the Original Premises and the Expansion Premises pursuant to the Lease, (b) the term “Property” shall refer to the Original Premises and the Expansion Premises on a collective basis, and
such Property shall consist of approximately 70,000 square feet, (c) the term of Tenant’s lease of the Original Premises and the Expansion Premises shall be co-terminus, and (d) Tenant’s
Initial Pro Rata Share of Common Area costs and all words of similar import shall mean 100%. From and after the Expansion Date, except as otherwise expressly set forth herein, all terms and conditions of the Lease shall apply to the Property
consisting of both the Original Premises and the Expansion Premises. 

 In the event Landlord is unable to deliver possession of the Expansion Premises to Tenant in the
condition required by this Amendment on the targeted Expansion Date of May 1, 2013, for any reason (including, without limitation, any holdover by any existing tenant of the Expansion Premises), Landlord shall have no liability to Tenant on
account thereof and the obligations of Tenant shall not be affected thereby, except that the (a) Expansion Date shall be extended until such time as Landlord delivers possession of the Expansion Premises to Tenant and (b) dates set forth
in the below schedule of Base Rent shall be adjusted to take into account the delay in the Expansion Date. Notwithstanding the preceding sentence, in the event that the Amendment is signed after May 1, 2013, the Rent Abatement Period as defined
below will not change and as such, the Landlord will reimburse the Tenant for any Rent previously paid to Landlord for the month of May 2013 within 30 days of the execution of this Amendment. 

3. Lease Term; Rent. The Lease Term is hereby extended for an additional seventy-eight (78) months (the “Extension
Term”), commencing on November 1, 2016 and ending on April 30, 2023 (the “Expiration Date”). Effective on the Expansion Date, and continuing through the Expiration Date the schedule of Base Rent set forth in
Section 1.12(a) of the Amended Lease is deleted and the following schedule is inserted in lieu thereof: 
  

									
	 Period
	  	Annual
Base Rent	 	  	Monthly
Installment
of Base Rent	 
	 May 1, 2013 — August 31, 2013 (“Rent Abatement Period”)
	  	$	0.00	  	  	$	0.00	  
	 September 1, 2013 — April 30, 2014
	  	 	N/A	  	  	$	64,750.00	  
	 May 1, 2014 — April 30, 2015
	  	$	800,310.00	  	  	$	66,692.50	  
	 May 1, 2015 — April 30, 2016
	  	$	824,319.30	  	  	$	68,693.28	  
	 May 1, 2016 — April 30, 2017
	  	$	849,048.88	  	  	$	70,754.07	  
	 May 1, 2017 — April 30, 2018
	  	$	874,520.35	  	  	$	72,876.70	  
	 May 1, 2018 — April 30, 2019
	  	$	900,755.96	  	  	$	75,063.00	  
	 May 1, 2019 — April 30, 2020
	  	$	927,778.63	  	  	$	77,314.89	  
	 May 1, 2020 — April 30, 2021
	  	$	955,611.99	  	  	$	79,634.33	  
	 May 1, 2021 — April 30, 2022
	  	$	984,280.35	  	  	$	82,023.36	  
	 May 1, 2022 — April 30, 2023
	  	$	1,013,808.76	  	  	$	84,484.06	  

 *Base Rent for the Rent Abatement Period (i.e., $64,750.00 per month, collectively, the “Abated Rent”)
shall be conditionally abated. The abatement of Abated Rent during the Rent Abatement Period provided for in this Section 3 is conditioned upon Tenant’s full and timely performance of all of its obligations under the Lease. If at any time
during the Lease Term (including the Extension Term), Tenant is in material default under the Lease according to Section 10.02 of the Lease, then the abatement of Abated Rent provided for in this provision shall immediately become void, and
Tenant shall promptly pay to Landlord, in addition to all other amounts due to Landlord under the Lease by reason of such default, the unamortized portion of the Abated Rent, which shall be calculated based on the number of remaining months of the
Lease Term (including the Extension Term) following the termination date divided by one hundred sixteen (116). 

  
 2 

 4. Additional Rent. In addition to the above monthly Base Rent amounts, Tenant
shall also be responsible for payment (to Landlord or such other party as may be required under the Lease) of any and all Additional Rent, and any other amounts, due under the terms of the Lease including, without limitation, (i) Tenant’s
Pro Rata Share of Common Area costs (including, without limitation, Impounds for Insurance Premiums and Property Taxes), and (ii) all utility services rendered or furnished to the Property. Tenant shall pay all of the foregoing amounts in
accordance with the terms of the Lease. 
 5. Tenant Improvement Allowance. Landlord shall contribute up to a maximum
amount of $450,000.00 (the “TI Allowance”) towards the costs of certain alterations to the Property to be constructed by Tenant (“Tenant Improvements”), which such payment shall be made by Landlord to Tenant
within 30 days following (a) completion of such Tenant Improvements, (b) Landlord’s receipt of Tenant’s invoice substantiating the costs related thereto, (c) Landlord’s receipt of final lien waivers from all
contractors and subcontractors who did work on such Tenant Improvements; and (d) Landlord’s receipt of a copy of the final permit approved by the applicable governing authority to the extent required for such Tenant Improvements. Landlord
shall be under no obligation to pay for any alterations or Tenant Improvements to the Property (i) in excess of the TI Allowance or (ii) if there exists a material default under Section 10.02 of the Lease. Such Tenant
Improvements hereunder shall be deemed alterations for purposes of the Lease, and, therefore, shall be governed by Section 6.05 of the Lease, and, further, notwithstanding anything to the contrary contained in the Lease, shall be subject to
Landlord’s approval of the plans and specifications related thereto. Tenant shall have the right to elect by written notice to Landlord (a “Rent Application Election”) to use up to 100% of the TI Allowance as a credit
against Rent, as they become due and payable. In the event that Tenant fails to properly request the TI Allowance or make a Rent Application Election on or prior to June 30, 2014, provided no default exists, then Tenant shall be deemed to
have made a Rent Application Election with respect to any remaining amount of TI Allowance, which shall be treated as a credit against Rent, up to the maximum amount of the next succeeding monthly installments of Rent until such credit is
satisfied. After June 30, 2014, provided no default exists, all TI Allowances or Rent Application Elections made by Tenant will be treated as credits against Rent, up to the maximum amount of the next succeeding monthly installments of
Rent until such credits are satisfied. In the event that the Lease Term ends before a credit to Rent can be applied, any remaining credit shall be paid by Landlord to Tenant within thirty (30) days after the end of the Lease Term provided that
no default exists under the Lease at such time. If a material default exists under Section 10.02 of the Lease as of June 30, 2014, Tenant shall be deemed to have waived its right to any remaining portion of the TI Allowance.

 6. Insurance Policies. Notwithstanding anything to the contrary contained in the Amended Lease, effective as of the
date hereof, Tenant shall be liable for Tenant’s Pro Rata Share of all deductibles on the insurance maintained by Landlord under Section 4.04 of the Lease, without limitation on the amount of such deductibles, including, without
limitation, Earthquake Insurance. 
 7. Limitation of Certain Costs. Effective as of the Expansion Date,
Paragraph 31 of Rider No. 1 of the Amended Lease is deleted in its entirety. 

  
 3 

 8. Maintenance of Common Areas. Effective as of the Expansion Date,
Section 4.05(d) of the Amended Lease is deleted in its entirety and replaced with the following provision: Landlord shall maintain the Common Areas in good order, condition and repair and shall operate the Project, as a first-class
industrial/commercial real property development. Tenant shall pay Tenant’s pro rata share (as determined below) of all costs incurred by Landlord for the operation and maintenance of the Common Areas. Common Area costs include, but are not
limited to, costs and expenses for the following: gardening and landscaping; utilities, water and sewage charges; maintenance of signs (other than Tenant’s signs); premiums for liability, property damage, fire and other types of casualty
insurance on the Common. Areas and worker’s compensation insurance; all property taxes and assessments levied on or attributable to the Common Areas and all Common Area improvements; all personal property taxes levied on or attributable to
personal property used in connection with the Common Areas; straight-line depreciation on personal property owned by Landlord which is consumed in the operation or maintenance of the Common Areas; rental or lease payments paid by Landlord for rented
or leased personal property used in the operation or maintenance-of the Common Areas; fees for required licenses and permits; repairing, resurfacing, repaving, maintaining, painting, lighting, cleaning, refuse
removal, security and similar items; reasonable reserves for roof replacement and exterior painting (the “Reserves”, which shall be established initially at $0.15 per square foot per year, which amount may be subsequently increased by
Landlord); replacement (when needed) of HVAC units based on a 20 year useful lifespan of an HVAC unit that will be prorated based on the number of years and months remaining on the Lease Term. (For example, if an HVAC unit is replaced when only
ten (10) years of Lease Term remains, Tenant shall only be responsible for 50% of the total cost because the lifespan of an HVAC unit is agreed by both parties to be 20 years. If an HVAC unit is replaced when only five (5) years of
Lease Term remains, Tenant shall only be responsible for twenty-five percent (25%) of the total cost because the useful lifespan of an HVAC unit is agreed by both parties to be 20 years and only 5 years of Lease Term remains. In the
event that the Lease Term is extended by the parties, Tenant shall remain liable to reimburse Landlord for the prorated cost of any HVAC unit (using a 20 year useful life span) that falls within such extended Lease Term. By way of example, if
an HVAC Unit is replaced when ten (10) years of Lease Term remains, Tenant shall only be responsible for 50% of the replacement cost of the HVAC unit replaced; however, if the Lease Term is then extended for an additional five (5) year
term (such term, the “Five Year Extension Term”), during such Five Year Extension Term Tenant shall reimburse Landlord for 25% of the cost of such replaced HVAC unit); and a reasonable allowance to Landlord for Landlord’s supervision
of the Common Areas (Tenant’s pro rata share of such supervision allowance (the “Supervision Allowance”) shall not exceed four percent (4%) of Base Rent and all reimbursable expenses pursuant to Article 4 for the applicable
period). Landlord may cause any and or all of such services to be provided by third parties and the cost of such services shall be included in Common Area costs. Common Area costs shall not include depreciation of real property, which forms part of
the Common Areas. Tenant agrees to provide Landlord with maintenance records pertaining to HVAC units, in form and substance satisfactory to Landlord, within 30 days of Landlord’s written request. Notwithstanding anything stated elsewhere
in the Amended Lease, the Landlord agrees to address as well as bear the total cost of (i) resurfacing, repaving, and restriping the parking lot within the first year of the date of this Amendment, and (ii) exterior painting of the
Building within the first year of the date of this Amendment. 

  
 4 

 Notwithstanding anything to the contrary contained in the Amended Lease, commencing as of
January 1, 2014, the aggregate amount that Tenant shall be obligated to reimburse pursuant to Section 4.05 (Common Area costs, which Common Area costs shall include Reserves), shall be limited to the actual amount of Controllable Operating
Expenses (as hereinafter defined) paid or incurred by Landlord on account of or in calendar year 2013, increased on a cumulative, compounding basis at five percent (5%) per annum through the applicable calendar year. In the event that the cap
applies to limit Tenant’s Pro Rata Share of Common Area costs attributable to Controllable Operating Expenses for any calendar year, the excluded amount (i.e., Controllable Operating Expenses incurred by Landlord in excess of the cap) shall be
carried forward to succeeding calendar years and recaptured by Landlord so long as the foregoing limit on the increase in the portion of Common Area costs attributable to Controllable Operating Expenses is not exceeded in any such succeeding year
such that amounts that could not be included in Common Area costs during such prior years may be re-captured by Landlord. The limitations on reimbursement set forth in this paragraph shall in no event apply to
limit Tenant’s obligations under (i) Section 4.02 (Property Taxes), (ii) Section 4.04 (Insurance Policies) and (iii) Section 4.05(d) (with respect to utilities, water and sewage charges and the Supervision
Allowance only) of the Amended Lease (all of the Common Area costs under the Lease, excluding, the costs under Sections 4.02, 4.04 and 4.05(d) (with respect to utilities, water and sewage charges and the Supervision Allowance only) of the
Amended Lease, are hereinafter referred to as the “Controllable Operating Expenses.”) Tenant shall remain fully liable to pay Landlord Tenant’s Pro Rata Share of all real property taxes on the Property and the cost of premiums
for insurance maintained by Landlord under the Lease, including any deductibles in connection therewith. 
 9. Options to
Extend Term Amendment Rider. Effective as of the date of this Amendment, (i) Rider No. 2 and (ii) the Option to Extend Term Amendment Rider attached to Amendment No. 1, are both deleted in their entirety. 

10. Right of First Offer. Effective as of the date of this Amendment, Paragraph 29 of Rider No. 1 is deleted in its
entirety. 
 11. Vehicle Parking Spaces Allocated to Tenant. Effective as of the Expansion Date, notwithstanding
anything to the contrary contained in the Amended Lease, Tenant shall be entitled to use all of the parking areas allocated to the Property. 

12. Tenant Improvements. Effective as of the date hereof, Section 5 of Amendment No. 1 is deleted in its entirety and
Landlord has no obligations under such section. 
 13. Property. Tenant hereby acknowledges that other than as required
in the Amended Lease including but not limited to Article 6 of the Amended Lease (i) Landlord shall have no obligation whatsoever to perform any work to the Property in connection with this Amendment, (ii) Tenant is familiar with and
has inspected the Property, and (iii) Tenant shall accept the Property on an “AS-IS,” “WHERE-IS” basis. 

  
 5 

 14. Confidential Information. Tenant agrees to maintain in strict confidence, other
than as required by law, (and to cause any broker representing Tenant to maintain in strict confidence, other than as required by law) all of the terms of this Amendment (including, without limitation, the economic terms contained herein) and
any or all other materials, data and information delivered to, or received by, any or all of Tenant and Tenant’s agents, representatives, employees, attorneys, and consultants either prior to or after the date hereof in connection with the
negotiation and execution of this Amendment. The provisions of this Section 14 shall survive the expiration or termination of the Lease. 

15. Full Force and Effect. Except as otherwise expressly provided herein, the Amended Lease shall be and remain in
full force and effect in accordance with its terms. 
 16. Counterparts and Signatures. This Amendment
and any document executed in connection herewith may be executed in counterparts, each of which shall be deemed an original, but all of which together shall constitute the same document. Facsimile machine or PDF copies of an original signature by
either party shall be binding as if said copies were original signatures. 
 17. Conflicts. If any of the
terms, covenants or conditions of this Amendment conflict with the terms, covenants or conditions of the Amended Lease, the terms, covenants and conditions of this Amendment shall control. 

18. Brokers’ Commission. Each of the parties hereto represents and warrants to the other that it has not
dealt with any broker in connection with this Amendment. Landlord shall indemnify, defend and hold harmless Tenant from and against all claims for broker’s commissions, finder’s fees or other commissions or fees made by any broker claiming
through Landlord. Tenant shall indemnify, defend and hold harmless Landlord from and against all claims for broker’s commissions, finder’s fees or other commissions or fees made by any broker claiming through Tenant. 

[Signature Page to Follow] 

  
 6 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed as of the day
and year first above written. 
  

					
	LANDLORD	 	
	
	KTR OC I LLC, a Delaware limited liability company
	
	By:   KTR Property Trust I, a Maryland real investment trust
	
	Its: Sole Member
		
	By:	 	/s/ Stephen J. Butte
	Name:	 	Stephen J. Butte
	Its:	 	Senior Vice President

  

			
	TENANT
	
	 ISOTIS ORTHOBIOLOGICS, INC., a

Washington corporation

		
	By:	 	/s/ John B. Henneman, III
	Name:	 	John B. Henneman, III
	Its:	 	Vice President, Treasurer & Assistant Secretary

  
 A-1

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