Document:

<PAGE>   1
                                                                     EXHIBIT 4.4
                                     WARRANT

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"), OR ANY STATE
SECURITIES LAWS. THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT
BE SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT FOR THESE SECURITIES UNDER THE SECURITIES ACT AND APPLICABLE STATE
SECURITIES LAWS, OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT
REGISTRATION IS NOT REQUIRED AND THAT AN APPLICABLE EXEMPTION IS AVAILABLE.

                               WARRANT TO PURCHASE
                        10,000 SHARES OF COMMON STOCK OF
                          AMYLIN PHARMACEUTICALS, INC.
                          (Void after December 7, 2002)

         This certifies that 1149336 Ontario Inc., a corporation formed under
the laws of the province of Ontario, Canada, or its permitted assigns (the
"Holder"), for value received, is entitled to purchase from AMYLIN
PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), having a place of
business at 9373 Towne Centre Drive, San Diego, California 92121, Ten Thousand
(10,000) fully paid and nonassessable shares of the Company's Common Stock
("Stock") for cash at a price of $3.313 per share (the "Stock Purchase Price")
at any time or from time to time on or after December 8, 1999 and up to and
including 5:00 p.m. (Pacific time) on December 7, 2002, such day being referred
to herein as the "Expiration Date", upon surrender to the Company at its
principal office (or at such other location as the Company may advise the Holder
in writing) of this Warrant properly endorsed with the Form of Subscription
attached hereto as Addendum A duly filled in and signed and upon payment in cash
or by check of the aggregate Stock Purchase Price for the number of shares for
which this Warrant is being exercised determined in accordance with the
provisions hereof. The Stock Purchase Price and the number of shares purchasable
hereunder are subject to adjustment as provided in Section 3 of this Warrant.

         This Warrant is subject to the following terms and conditions:

         1. EXERCISE; ISSUANCE OF CERTIFICATES; PAYMENT FOR SHARES.

            1.1 GENERAL. This Warrant is exercisable at the option of the
holder of record hereof at any time or from time to time on or after January
___, 2000 and up to and including the Expiration Date for all or any part of the
shares of Stock (but not for a fraction of a share) which may be purchased
hereunder. The Company agrees that the shares of Stock purchased under this
Warrant shall be and are deemed to be issued to the Holder hereof as the record
owner of such shares as of the close of business on the date on which this
Warrant shall have been surrendered, properly endorsed, the completed, executed
Form of Subscription delivered and payment made for such shares. Certificates
for the shares of Stock so purchased, together with any other securities or
property to which the Holder hereof is entitled upon such exercise, shall be

<PAGE>   2

delivered to the Holder hereof by the Company at the Company's expense within a
reasonable time after the rights represented by this Warrant have been so
exercised. In case of a purchase of less than all the shares which may be
purchased under this Warrant, the Company shall cancel this Warrant and execute
and deliver a new Warrant or Warrants of like tenor for the balance of the
shares purchasable under the Warrant surrendered upon such purchase to the
Holder hereof within a reasonable time. Each stock certificate so delivered
shall be in such denominations of Stock as may be requested by the Holder hereof
and shall be registered in the name of such Holder.

         Notwithstanding anything to the contrary contained in this Section 1,
the Holder shall either (i) exercise this Warrant in full by paying to the
Company, by cash or check, an amount equal to the aggregate Stock Purchase Price
of the shares being purchased, or (ii) convert this Warrant into shares equal to
the value (as determined below) of this Warrant by surrender of this Warrant a
the principal office of the Company together with the Form of Subscription in
which event the Company shall issue to the Holder a number of shares of Common
Stock computed using the following formula:

                  X = Y (A-B)
                  -----------
                         A

Where:            X = the number of shares of Common Stock to be issued to the
                  Holder. Y = the number of shares of Common Stock under this
                  Warrant. A = the fair market value of one share of Common
                  Stock (at the date of such surrender). B = the Stock Purchase
                  Price (as adjusted to the date of such surrender).

         As used herein, current fair market value of Common Stock shall mean
with respect to each share of Common Stock the closing price of the Company's
Common Stock as quoted on the Nasdaq Stock Market, or, if on any day the Common
Stock is not so listed, the average of the highest bid and the lowest asked
price on such day in the domestic over-the-counter market as reported by the
National Quotation Bureau, Incorporated, or any similar successor organization,
in each case averaged over a period of 15 trading days consisting of the day as
of which the current fair market value of Common Stock is being determined and
the 14 consecutive trading days prior to such day. If at any time the Common
Stock is not listed on any securities exchange or quoted in the over-the-counter
market, the current fair market value of Common Stock shall be used for the
calculation of A above, and shall be determined in good faith by the Board of
Directors of the Company.

         2. SHARES TO BE FULLY PAID; RESERVATION OF SHARES. The Company
covenants and agrees that all shares of Stock which may be issued upon the
exercise of the rights represented by this Warrant will, upon issuance, be duly
authorized, validly issued, fully paid and nonassessable and free from all
preemptive rights of any shareholder and free of all taxes, liens and charges
with respect to the issue thereof. The Company further covenants and agrees that
during the period within which the rights represented by this Warrant may be
exercised, the Company will at all times have authorized and reserved, for the
purpose of issue or transfer upon exercise of the subscription rights evidenced
by this War-rant, a sufficient number of shares of authorized but unissued
Stock, or other securities and property, when and as required to provide for the
exercise

<PAGE>   3

of the rights represented by this Warrant. The Company will take all such action
as may be necessary to assure that such shares of Stock may be issued as
provided herein without violation of any applicable law or regulation, or of any
requirements of any domestic securities exchange upon which the Stock may be
listed; provided, however, that the Company shall not be required to effect a
registration under Federal or State securities laws with respect to such
exercise. The Company will not take any action which would result in any
adjustment of the Stock Purchase Price (as defined in Section 3 hereof) if the
total number of shares of Stock issuable after such action upon exercise of all
outstanding warrants, together with all shares of Stock then issuable upon
exercise of all options and upon the conversion of all convertible securities
then outstanding, would exceed the total number of shares of Stock then
authorized by the Company's Certificate of Incorporation.

         3. ADJUSTMENT OF STOCK PURCHASE PRICE AND NUMBER OF SHARES. The Stock
Purchase Price and the number of shares purchasable upon the exercise of this
Warrant shall be subject to adjustment from time to time upon the occurrence of
certain events described in this Section 3. Upon each adjustment of the Stock
Purchase Price, the Holder of this Warrant shall thereafter be entitled to
purchase, at the Stock Purchase Price resulting from such adjustment, the number
of shares obtained by multiplying the Stock Purchase Price in effect immediately
prior to such adjustment by the number of shares purchasable pursuant hereto
immediately prior to such adjustment, and dividing the product thereof by the
Stock Purchase Price resulting from such adjustment.

            3.1 SUBDIVISION OR COMBINATION OF STOCK. In case the Company shall
at any time subdivide its outstanding shares of Stock into a greater number of
shares, the Stock Purchase Price in effect immediately prior to such subdivision
shall be proportionately reduced, and conversely, in case the outstanding shares
of Stock of the Company shall be combined into a smaller number of shares, the
Stock Purchase Price in effect immediately prior to such combination shall be
proportionately increased.

            3.2 DIVIDENDS IN STOCK, OTHER STOCK, PROPERTY, RECLASSIFICATION. If
at any time or from time to time all holders of shares of the Company's Common
Stock (or any shares of stock or other securities at the time receivable upon
the exercise of this Warrant) shall have received or become entitled to receive,
without payment therefor,

                (A) Stock or any shares of stock or other securities which are
at any time directly or indirectly convertible into or exchangeable for Stock,
or any rights or options to subscribe for, purchase or otherwise acquire any of
the foregoing by way of dividend or other distribution, or

                (B) Stock or additional stock or other securities or property
(including cash) by way of spin-off, split-up, reclassification, combination of
shares or similar corporate rearrangement, (other than shares of Stock issued as
a stock split, adjustments in respect of which shall be covered by the terms of
Section 3.1 above), then and in each such case, the Holder hereof shall, upon
the exercise of this Warrant, be entitled to receive, in addition to the number
of shares of Stock receivable thereupon, and without payment of any additional
consideration therefor, the amount of stock and other securities and property
which such Holder would hold on the date of such exercise had he been the holder
of record of such Stock as of the

<PAGE>   4

date on which holders of Stock received or became entitled to receive such
shares or all other additional stock and other securities and property.

            3.3 REORGANIZATION, RECLASSIFICATION, CONSOLIDATION, MERGER OR SALE.
If any capital reorganization of the capital stock of the Company, or any
consolidation or merger of the Company with another corporation, or the sale of
all or substantially all of its assets to another corporation shall be effected
in such a way that holders of Stock shall be entitled to receive stock,
securities, or other assets or property, then, as a condition of such
reorganization, reclassification, consolidation, merger or sale, lawful and
adequate provisions shall be made whereby the Holder hereof shall thereafter
have the right to purchase and receive (in lieu of the shares of the Stock of
the Company immediately theretofore purchasable and receivable upon the exercise
of the rights represented hereby) such shares of stock, securities or other
assets or property as may be issued or payable with respect to or in exchange
for a number of outstanding shares of such Stock equal to the number of shares
of such stock immediately theretofore purchasable and receivable upon the
exercise of the rights represented hereby. In any reorganization described
above, appropriate provision shall be made with respect to the rights and
interests of the Holder of this Warrant to the end that the provisions hereof
(including, without limitation, provisions for adjustments of the Stock Purchase
Price and of the number of shares purchasable and receivable upon the exercise
of this Warrant) shall thereafter be applicable, as nearly as may be, in
relation to any shares of stock, securities or assets thereafter deliverable
upon the exercise hereof.

            3.4 NOTICE OF ADJUSTMENT. Upon any adjustment of the Stock Purchase
Price or any increase or decrease in the number of shares purchasable upon the
exercise of this Warrant, the Company shall give written notice thereof, by
first class mail, postage prepaid, addressed to the registered Holder of this
Warrant at the address of such Holder as shown on the books of the Company. The
notice shall be signed by the Company's chief financial officer and shall state
the Stock Purchase Price resulting from such adjustment and the increase or
decrease, if any, in the number of shares purchasable at such price upon the
exercise of this Warrant, setting forth in reasonable detail the method of
calculation and the facts upon which such calculation is based.

            3.5 OTHER NOTICES. If at any time:

                (1) the Company shall declare any cash dividend upon its Common
Stock;

                (2) the Company shall declare any dividend upon its Common Stock
payable in stock or make any special dividend or other distribution to the
holders of its Common Stock;

                (3) the Company shall offer for subscription pro rata to the
holders of its Common Stock any additional shares of stock of any class or other
rights;

                (4) there shall be any capital reorganization or
reclassification of the capital stock of the Company; or consolidation or merger
of the Company with, or sale of all or substantially all of its assets to,
another corporation; or

<PAGE>   5

                (5) there shall be a voluntary or involuntary dissolution,
liquidation or winding-up of the Company;

                (6) then, in any one or more of said cases, the Company shall
give, by first class mail, postage prepaid, addressed to the Holder of this
Warrant at the address of such Holder as shown on the books of the Company, (a)
at least 20 days' prior written notice of the date on which the books of the
Company shall close or a record shall be taken for such dividend, distribution
or subscription rights or for determining rights to vote in respect of any such
reorganization, reclassification, consolidation, merger, sale, dissolution,
liquidation or winding-up, and (b) in the case of any such reorganization,
reclassification, consolidation, merger, sale, dissolution, liquidation,
winding-up or public offering, at least 20 days' prior written notice of the
date when the same shall take place; provided, however, that the Holder shall
make a best efforts attempt to respond to such notice as early as possible after
the receipt thereof. Any notice given in accordance with the foregoing clause
(a) shall also specify, in the case of any such dividend, distribution or
subscription rights, the date on which the holders of Common Stock shall be
entitled thereto. Any notice given in accordance with the foregoing clause (b)
shall also specify the date on which the holders of Stock shall be entitled to
exchange their Stock for securities or other property deliverable upon such
reorganization, reclassification, consolidation, merger, sale, dissolution,
liquidation, winding-up, con-version or public offering, as the case may be.

         4. ISSUE TAX. The issuance of certificates for shares of Stock upon the
exercise of the Warrant shall be made without charge to the Holder of the
Warrant for any issue tax (other than any applicable income taxes) in respect
thereof; provided, however, that the Company shall not be required to pay any
tax which may be payable in respect of any transfer involved in the issuance and
delivery of any certificate in a name other than that of the then Holder of the
Warrant being exercised.

         5. CLOSING OF BOOKS. The Company will at no time close its transfer
books against the transfer of any warrant or of any shares of Stock issued or
issuable upon the exercise of any warrant in any manner which interferes with
the timely exercise of this Warrant.

         6. NO VOTING OR DIVIDEND RIGHTS; LIMITATION OF LIABILITY. Nothing
contained in this Warrant shall be construed as conferring upon the Holder
hereof the right to vote or to consent or to receive notice as a shareholder of
the Company or any other matters or any rights whatsoever as a shareholder of
the Company. No dividends or interest shall be payable or accrued in respect of
this Warrant or the interest represented hereby or the shares purchasable
hereunder until, and only to the extent that, this Warrant shall have been
exercised. No provisions hereof, in the absence of affirmative action by the
Holder to purchase shares of Stock, and no mere enumeration herein of the rights
or privileges of the Holder hereof, shall give rise to any liability of such
Holder for the Stock Purchase Price or as a shareholder of the Company, whether
such liability is asserted by the Company or by its creditors.

         7. WARRANTS TRANSFERABLE. Subject to compliance with applicable federal
and state securities laws, this Warrant and all rights hereunder are
transferable, in whole, without charge to the Holder hereof (except for transfer
taxes), upon surrender of this Warrant properly endorsed. Each taker and holder
of this Warrant, by taking or holding the same, consents and agrees that

<PAGE>   6

this Warrant, when endorsed in blank, shall be deemed negotiable, and that the
Holder hereof, when this Warrant shall have been so endorsed, may be treated by
the Company, at the Company's option, and all other persons dealing with this
Warrant as the absolute owner hereof for any purpose and as the person entitled
to exercise the rights represented by this Warrant, or to the transfer hereof on
the books of the Company any notice to the contrary notwithstanding; but until
such transfer on such books, the Company may treat the registered owner hereof
as the owner for all purposes.

         8. MODIFICATION AND WAIVER. This Warrant and any provision hereof may
be changed, waived, discharged or terminated only by an instrument in writing
signed by the Company and the Holder.

         9. NOTICES. Any notice, request or other document required or permitted
to be given or delivered to the Holder hereof or the Company shall be delivered
or shall be sent by certified mail, postage prepaid, to each such holder at its
address as shown on the books of the Company or to the Company at the address
indicated therefor in the first paragraph of this Warrant or such other address
as either may from time to time provide to the other.

         10. BINDING EFFECT ON SUCCESSORS. This Warrant shall be binding upon
any corporation succeeding the Company by merger, consolidation or acquisition
of all or substantially all of the Company's assets. All of the obligations of
the Company relating to the Stock issuable upon the exercise of this Warrant
shall survive the exercise and termination of this Warrant. All of the covenants
and agreements of the Company shall inure to the benefit of the successors and
assigns of the Holder hereof.

         11. DESCRIPTIVE HEADINGS AND GOVERNING LAW. The description headings of
the several sections and paragraphs of this Warrant are inserted for convenience
only and do not constitute a part of this Warrant. This Warrant shall be
construed and enforced in accordance with, and the rights of the parties shall
be governed by, the laws of the State of Delaware without regard to conflict of
laws principles.

         12. LOST WARRANTS. The Company represents and warrants to the Holder
hereof that upon receipt of evidence reasonably satisfactory to the Company of
the loss, theft, destruction, or mutilation of this Warrant and, in the case of
any such loss, theft or destruction, upon receipt of an indemnity reasonably
satisfactory to the Company, or in the case of any such mutilation upon
surrender and cancellation of such Warrant, the Company, at its expense, will
make and deliver a new Warrant, of like tenor, in lieu of the lost, stolen,
destroyed or mutilated Warrant.

         13. FRACTIONAL SHARES. No fractional shares shall be issued upon
exercise of this Warrant. The Company shall, in lieu of issuing any fractional
share, pay the holder entitled to such fraction a sum in cash equal to such
fraction multiplied by the then effective Stock Purchase Price.

<PAGE>   7
         IN WITNESS WHEREOF, the Company has caused this Warrant to be duly
executed by its officers, thereunto duly authorized this 8th day of December,
1999.

                                AMYLIN PHARMACEUTICALS, INC.,
                                a Delaware corporation.

                                By:
                                   --------------------------------------
                                   Joseph C. Cook, Jr.
                                   Chief Executive Officer and
                                   Chairman of the Board of Directors

<PAGE>   8

                                    EXHIBIT A

                                SUBSCRIPTION FORM

                                               Date:  _________________, 19___

AMYLIN PHARMACEUTICALS, INC.
9373 Towne Centre Drive
San Diego, California 92121
Attn:  Chief Executive Officer

Ladies and Gentlemen:

The undersigned hereby elects to exercise the warrant issued to it by AMYLIN
PHARMACEUTICALS, INC. (the "Company") and dated ________________, 2000 (the
"Warrant") and to purchase thereunder __________________________________ shares
of the Common Stock of the Company (the "Shares") at a purchase price of
________________ ($______) per Share or an aggregate purchase price of
__________________ ________________ Dollars ($__________) (the "Purchase
Price").

         Pursuant to the terms of the Warrant the undersigned has delivered the
Purchase Price herewith in full in cash or by certified check or wire transfer.
The undersigned also makes the representations set forth on Exhibit B attached
to the Warrant.

                                               Very truly yours,

                                               1149336 ONTARIO, INC.

                                               By:
                                                  --------------------------
                                               Title:
                                                     -----------------------
                                      A-1.

<PAGE>   9
                                    EXHIBIT B

                             TO WARRANT CERTIFICATE

THIS AGREEMENT MUST BE COMPLETED, SIGNED AND RETURNED TO AMYLIN PHARMACEUTICALS,
INC. ALONG WITH THE SUBSCRIPTION FORM BEFORE THE STOCK ISSUABLE UPON EXERCISE OF
THE WARRANT CERTIFICATE DATED DECEMBER 8, 1999 WILL BE ISSUED.

                           _____________________, 20__

AMYLIN PHARMACEUTICALS, INC.
9373 Towne Centre Drive
San Diego, California 92121
Attn:  Chief Executive Officer

The undersigned, 1149336 Ontario, Inc., a corporation formed under the laws of
the province of Ontario, Canada ("Purchaser"), intends to acquire up to
______________ shares of the Common Stock (the "Stock") of AMYLIN
PHARMACEUTICALS, INC. (the "Company") from the Company pursuant to the exercise
of a certain Warrant to purchase Stock held by Purchaser. The Stock will be
issued to Purchaser in a transaction not involving a public offering and
pursuant to an exemption from registration under the Securities Act of 1933, as
amended (the "1933 Act") and applicable state securities laws. In connection
with such purchase and in order to comply with the exemptions from registration
relied upon by the Company, Purchaser represents, warrants and agrees as
follows:

         Purchaser is acquiring the Stock for its own account, to hold for
investment, and Purchaser shall not make any sale, transfer or other disposition
of the Stock in violation of the 1933 Act or the General Rules and Regulations
promulgated thereunder by the Securities and Exchange Commission (the "SEC") or
in violation of any applicable state securities law.

         Purchaser has been advised that the Stock has not been registered under
the 1933 Act or state securities laws on the ground that this transaction is
exempt from registration, and that reliance by the Company on such exemptions is
predicated in part on Purchaser's representations set forth in this letter.

         Purchaser has been informed that under the 1933 Act, the Stock must be
held indefinitely unless it is subsequently registered under the 1933 Act or
unless an exemption from such registration (such as Rule 144) is available with
respect to any proposed transfer or disposition by Purchaser of the Stock.
Purchaser further agrees that the Company may refuse to permit Purchaser to
sell, transfer or dispose of the Stock (except as permitted under Rule 144)
unless there is in effect a registration statement under the 1933 Act and any
applicable state securities

                                      B-1.
<PAGE>   10

Warrant Agreement
1149336 ONTARIO, INC.

laws covering such transfer, or unless Purchaser furnishes an opinion of counsel
reasonably satisfactory to counsel for the Company, to the effect that such
registration is not required.

         Purchaser also understands and agrees that there will be placed on the
certificate(s) for the Stock, or any substitutions therefor, a legend stating in
substance:

                  "The shares represented by this certificate have not been
         registered under the Securities Act of 1933, as amended (the
         "Securities Act"), or any state securities laws. These shares have been
         acquired for investment and may not be sold or otherwise transferred in
         the absence of an effective registration statement for these shares
         under the Securities Act and applicable state securities laws, or an
         opinion of counsel satisfactory to the Company that registration is not
         required and that an applicable exemption is available."

         Purchaser has carefully read this letter and has discussed its
requirements and other applicable limitations upon Purchaser's resale of the
Stock with Purchaser's counsel.

                                   Very truly yours,

                                   Name of Purchaser:

                                   1149336 ONTARIO, INC.

                                   By:
                                      ------------------------------

                                   Title:
                                         ---------------------------

                                      B-2.EXECUTION COPY

--------------------------------------------------------------------------------

                            REORGANIZATION AGREEMENT

                                      among

                                CAREINSITE, INC.

                                       and

                 THE HEALTH INFORMATION NETWORK CONNECTION LLC,

                          GNYHA MANAGEMENT CORPORATION,

                       EMPIRE BLUE CROSS AND BLUE SHIELD,

                            GROUP HEALTH INCORPORATED

                                       and

                  HEALTH INSURANCE PLAN OF GREATER NEW YORK

                          dated as of December 31, 1999

--------------------------------------------------------------------------------

<PAGE>

                                TABLE OF CONTENTS

Section                                                                     Page

                                    ARTICLE I

                                   DEFINITIONS

1.01.  Certain Defined Terms...................................................2

                                   ARTICLE II

                             DISTRIBUTION OF WARRANT

2.01.  Distribution of Warrant.................................................3
2.02.  First Closing...........................................................3
2.03.  First Closing Deliveries by the Company.................................3
2.04.  First Closing Deliveries by the Original Members........................4
2.05.  Distribution in Liquidation of Minority Interest........................4
2.06.  Second Closing..........................................................4
2.07.  Further Assurances......................................................5

                                   ARTICLE III

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

3.01.  Due Organization and Authority..........................................5
3.02.  Capital Stock of the Company............................................6
3.03.  SEC Filings and Financial Statements; Absence of Undisclosed
         Liabilities...........................................................6
3.04.  No Conflict.............................................................7
3.05.  Governmental Consents and Approvals.....................................7

                                   ARTICLE IV

                               REPRESENTATIONS AND
                         WARRANTIES OF ORIGINAL MEMBERS

4.01.  Organization and Authority..............................................8
4.02.  No Encumbrances.........................................................8
4.03.  No Conflict.............................................................8
4.04.  Governmental Consents and Approvals.....................................9
4.05.  Private Placement.......................................................9

<PAGE>

Section                                                                    Page

                                    ARTICLE V

                              ADDITIONAL AGREEMENTS

5.01.  Advisory Board..........................................................9
5.02.  Registration Rights Agreement..........................................10
5.03.  Amended and Restated Operating Agreement...............................10
5.04.  Tax Treatment..........................................................10
5.05.  Outstanding Notes......................................................10
5.06.  Working Capital Loan Agreement and Promissory Note.....................10
5.07.  HSR Act................................................................10

                                   ARTICLE VI

                                  MISCELLANEOUS

6.01.  Survival of Representations and Warranties.............................11
6.02.  Termination............................................................11
6.03.  Expenses...............................................................11
6.04.  Notices................................................................11
6.05.  Headings...............................................................12
6.06.  Modification; Severability.............................................12
6.07.  Integration............................................................12
6.08.  Assignment.............................................................12
6.09.  No Third-Party Beneficiaries...........................................12
6.10.  Amendment..............................................................12
6.11.  Governing Law..........................................................12
6.12.  Counterparts...........................................................12
6.13.  Specific Performance...................................................13
6.14.  Nonwaiver; Cumulative Remedies.........................................13

Schedule I.............................................................Addresses

                                       ii

<PAGE>

                            REORGANIZATION AGREEMENT

          This REORGANIZATION AGREEMENT, dated as of December 31, 1999, among
CareInsite, Inc., a Delaware corporation (the "Company"), The Health Information
Network Connection LLC, a New York limited liability company ("THINC"), and its
four other members, Empire Blue Cross and Blue Shield, a New York not-for-profit
company ("Empire"), Group Health Incorporated, a New York corporation ("GHI"),
Health Insurance Plan of Greater New York, a New York not-for-profit corporation
("HIP") and GNYHA Management Corporation, a New York corporation ("GNYHA")
(each, an "Original Member" and collectively, the "Original Members").

                              W I T N E S S E T H:

          WHEREAS, the Company is an Internet-based company that is developing
and intends to provide an Internet-based healthcare electronic commerce, or
e-commerce, network that links physicians, payers, suppliers and patients;

          WHEREAS, THINC is an entity founded by the Original Members to
facilitate the confidential exchange of healthcare information;

          WHEREAS, the Company has contributed to THINC Acquisition Corp., a
wholly owned subsidiary of the Company ("CareInsite Sub") a 0.96% interest in
THINC so that CareInsite Sub has a 0.96% interest in THINC;

          WHEREAS, THINC, the Company, CareInsite Sub and the Original Members
have agreed to enter into an amended and restated operating agreement (the
"Amended and Restated Operating Agreement") in the form attached as Exhibit A,
on the date hereof, so that, among other things, the Company shall have a 95.04%
interest in THINC, CareInsite Sub shall have a 0.96% interest in THINC and each
Original Member shall have a 1% interest in THINC (the 1% interest of each
Original Member being referred to herein as its "Minority Interest");

          WHEREAS, THINC is a holder of a Warrant to purchase 4,059,118 shares
of the Company's common stock ("Common Stock") dated as of January 1, 1999 (the
"Warrant");

          WHEREAS, THINC shall, on the date hereof, distribute to each Original
Member and each Original Member shall accept a portion of the Warrant and, on
the date hereof, the Company shall issue to each of the Original Members (a) a
new warrant (the "Prorata New Warrant") in the form attached as Exhibit B which
provides substantially identical terms and conditions as the Warrant, including
a provision that each Original Member may effect a cashless exercise of its
respective Prorata New Warrant for 767,904 shares of Common Stock and which
represents a total number of shares equal to the shares represented by such
Original Member's pro rata portion of the Warrant and (b) a new warrant (the
"Additional New Warrant" and, together with the Prorata New Warrant, the "First
Closing Warrants") in the form attached as

<PAGE>

Exhibit B which provides, among other things, that each Original Member may
effect a cashless exercise of its respective Additional New Warrant for 150,100
shares of Common Stock;

          WHEREAS, the Company and the Original Members shall enter into a
registration rights agreement (the "Registration Rights Agreement") on the date
hereof in the form attached as Exhibit C;

          WHEREAS, as soon as practicable after expiration or termination of all
applicable waiting periods under the HSR Act, THINC shall distribute to each
Original Member in liquidation of such Original Member's Minority Interest a
portion of the Warrant representing the right to purchase in a cashless exercise
100 shares of Common Stock pursuant to the terms of the Warrant;

          WHEREAS, the Company has agreed to assume all of the obligations of
THINC under the working capital loan agreement between THINC and the Company
dated as of January 1, 1999 (the "Working Capital Loan Agreement") and the
promissory note between THINC and the Company dated as of December 10, 1999 (the
"Promissory Note"), as well as the obligations to repay certain loans extended
by each Original Member to THINC as set forth in Section 5.05 hereof which shall
be repaid by the Company simultaneously with the consummation of the First
Closing contemplated by this Agreement.

          WHEREAS, the Company shall deliver a guaranty (each, a "Guaranty") to
each Original Member guaranteeing such Original Member's obligations under the
corporate guarantee that such Original Member delivered to Sun Data, Inc. in
February 1997 and certain related obligations.

          NOW, THEREFORE, in consideration of the premises and of the mutual
covenants and agreements hereinafter set forth, the parties hereby agree as
follows:

                                    ARTICLE I

                                   DEFINITIONS

          SECTION 1.01. Certain Defined Terms. As used in this Agreement, the
following terms shall have the following meanings:

                  "Agreement" means this Reorganization Agreement, dated as of
         December 31, 1999, and all amendments made hereto in accordance with
         the provisions hereof.

                  "Business Day" means any day except a Saturday, Sunday or
         other day on which commercial banks in the State of New York are
         authorized or required by law or executive order to close.

                                        2

<PAGE>

                  "Commission" means the Securities and Exchange Commission or
         any other federal agency then administering the Securities Act (as
         defined below) and other federal securities laws.

                  "Exchange Act" means the Securities Exchange Act of 1934, as
         amended and the rules and regulations promulgated by the Commission
         thereunder.

                  "HSR Act" means the Hart-Scott-Rodino Antitrust Improvements
         Act of 1976, as amended.

                  "Person" means any individual, partnership, firm, corporation,
         association, trust, unincorporated organization or other entity, as
         well as any syndicate or group that would be deemed to be a Person
         under Section 13(d)(3) of the Exchange Act.

                  "Securities Act" means the Securities Act of 1933, as amended,
         and the rules and regulations promulgated by the Commission thereunder.

                                   ARTICLE II

                             DISTRIBUTION OF WARRANT

          SECTION 2.01. Distribution of Warrant. (a) Upon the terms and subject
to the conditions set forth in this Agreement and the Warrant, at the First
Closing (as defined below) THINC shall distribute to each Original Member and
each Original Member shall accept a portion of the Warrant representing the
right to purchase in a cashless exercise (a) 767,904 shares of Common Stock
pursuant to the Prorata New Warrant and (b) 150,100 shares of Common Stock
pursuant to the Additional New Warrant. Each Original Member's pro rata portion
of the Warrant shall be evidenced by the Prorata New Warrant and an additional
portion of the Warrant shall be evidenced by the Additional New Warrant both in
the form attached as Exhibit B.

          (b) Effective immediately after the distribution of the First
Closing New Warrants, the Warrant is hereby amended so that the number of shares
of Common Stock that may be purchased thereunder shall be 177,084.

          SECTION 2.02. First Closing. Upon the terms and subject to the
conditions set forth in this Agreement, the transactions provided for in Section
2.01 shall take place at a closing (the "First Closing") to be held at the
offices of Shearman & Sterling, 599 Lexington Avenue, New York, New York at
10:00 A.M. New York time on January 18, 2000.

          SECTION 2.03. First Closing Deliveries by the Company. At the First
Closing, the Company shall deliver to each of the Original Members:

                                        3

<PAGE>

                  (a) a signature page to the Amended and Restated Operating
         Agreement executed by the Company;

                  (b) a signature page to each of the Prorata New Warrant and
         the Additional New Warrant for such Original Member executed by the
         Company;

                  (c) a signature page to the Registration Rights Agreement
         executed by the Company;

                  (d) payment in full of the amounts due under each of the
         promissory notes listed in Section 5.05 hereof; and

                  (e) an executed copy of the Guaranty.

          SECTION 2.04. First Closing Deliveries by the Original Members. At the
First Closing, each Original Member shall deliver to the Company:

                  (a) a signature page to the Amended and Restated Operating
         Agreement executed by such Original Member;

                  (b) an executed copy of the Notice of Cashless Exercise
         pursuant to each of the Prorata New Warrant and the Additional New
         Warrant of such Original Member;

                  (c) a signature page to the Registration Rights Agreement
         executed by such Original Member; and

                  (d) original canceled promissory note(s) listed for such
         Original Member in Section 5.05 of this Agreement.

          SECTION 2.05. Distribution in Liquidation of Minority Interest. Upon
the terms and subject to the conditions set forth in this Agreement, at the
Second Closing (as defined below), THINC shall distribute to each Original
Member in liquidation of such Original Member's Minority Interest and each of
the Original Members shall accept a new warrant (the "Second Closing Warrant"
and, together with the First Closing Warrants, the "New Warrants") in the form
attached as Exhibit B, which provides, among other things, that each Original
Member may effect a cashless exercise of its respective Second Closing Warrant
for 100 shares of Common Stock.

          SECTION 2.06. Second Closing. (a) Upon the terms and subject to the
conditions set forth in this Agreement, the transactions provided for in Section
2.05 shall take place at a closing (the "Second Closing"), to be held at the
offices of Shearman & Sterling subject to and as soon as practicable following
but no later than five (5) Business Days following the expiration or termination
of any applicable waiting periods under the HSR Act.

                                        4

<PAGE>

          (b) If the Second Closing does not occur by March 1, 2000, then each
Original Member shall have the right to transfer or sell for 100 shares of
Common Stock such Original Member's Minority Interest to any Person designated
by the Company by written notice to such Original Member prior to such date and
at the request of such Original Member the Company shall designate and cause
such Person to purchase such Original Member's Minority Interest by March 8,
2000.

          SECTION 2.07. Further Assurances. Each of the parties hereto shall use
reasonable efforts to take, or cause to be taken, all appropriate action, and to
do, or cause to be done, all things necessary, proper or advisable under
applicable laws to consummate and make effective the transactions contemplated
hereunder, including, without limitation, using reasonable efforts to obtain all
licenses, permits, consents, approvals, authorizations, qualifications and
orders of the appropriate governmental entities. Without limiting the generality
of the foregoing, the parties shall, when required in order to effect the
transactions contemplated hereunder, make all necessary filings, and thereafter
make any other required or appropriate submissions, under the HSR Act and shall
supply as promptly as practicable to the appropriate governmental entity any
additional information and documentary material that may be requested pursuant
to the HSR Act. Each of the parties shall cooperate with the others when
required in order to effect the transactions contemplated hereunder. In case, at
any time after the date hereof, any further action is necessary or desirable to
carry out the purposes of this Agreement, the proper officers and directors of
each of the parties shall use their reasonable best efforts to take all such
action.

                                   ARTICLE III

                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

          The Company represents and warrants to THINC and each of the Original
Members as follows:

          SECTION 3.01. Due Organization and Authority. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware and has all necessary power and authority to enter into
this Agreement, the Registration Rights Agreement, the Amended and Restated
Operating Agreement and each of the Guarantys, dated as of the date hereof and
the New Warrants (collectively, the "Transaction Documents") to carry out its
obligations hereunder and thereunder and to consummate the transactions
contemplated hereby and thereby. The Company is duly licensed or qualified to do
business and is in good standing in each jurisdiction in which the properties
owned or leased by it or the operation of its business makes such licensing or
qualification necessary, except to the extent that the failure to be so licensed
or qualified would not materially and adversely affect the Company's assets,
liabilities or results of operations or prevent or delay the consummation of the
transactions contemplated by the Transaction Documents. The execution and
delivery of the Transaction Documents by the Company, the performance by the
Company of its obligations hereunder and

                                        5

<PAGE>

thereunder and the consummation by the Company of the transactions contemplated
hereby and thereby have been duly authorized by all requisite action on the part
of the Company. The Transaction Documents have been duly executed and delivered
by the Company, and (assuming due authorization, execution and delivery by the
other parties thereto) the Transaction Documents constitute legal, valid and
binding obligations of the Company, enforceable against the Company in
accordance with their respective terms.

          SECTION 3.02. Capital Stock of the Company. The Common Stock to be
issued by the Company upon exercise of the New Warrants has been duly authorized
and, when issued and delivered in accordance with the terms of the New Warrants
or this Agreement, as the case may be, will have been validly issued and will be
fully paid and nonassessable, and will be free from restrictions on transfer
other than restrictions on transfer under the Transaction Documents and under
applicable state and federal securities laws. No Person has any preemptive or
similar rights with respect to the Common Stock, and neither the parties hereto
nor subsequent holders in due course of such Common Stock will be entitled to
any such preemptive or similar rights. The authorized capital stock of the
Company consists of (i) 300,000,000 shares of Common Stock and (ii) 30,000,000
shares of preferred stock, par value $0.01 per share (the "Preferred Stock"). As
of December 29, 1999, (i) 70,410,134 shares of Common Stock were issued and
outstanding, (ii) no shares of Common Stock were held in the treasury of the
Company, (iii) 8,382,512 shares of Common Stock were reserved for issuance upon
exercise of outstanding warrants, (iv) 812,184 shares of Common Stock were
reserved for issuance upon the conversion of shares of Series A Convertible
Redeemable Preferred Stock and upon exercise of other related warrants upon such
conversion, (v) 100 shares of Series A Convertible Redeemable Preferred Stock
were issued and outstanding, (vi) 100 shares of Series A Convertible Redeemable
Preferred Stock were reserved for issuance, (vii) 7,557,200 shares of Common
Stock were reserved for future issuance pursuant to the Company's stock option
plans and arrangements (with respect to which options to acquire not more than
6,568,000 shares of Common Stock are outstanding).

          SECTION 3.03. SEC Filings and Financial Statements; Absence of
Undisclosed Liabilities. (a) The Company has filed all forms, reports and
documents required to be filed by it with the Commission ("SEC Reports") since
June 16, 1999. Except as set forth in the SEC Reports filed prior to the date of
this Agreement, as of the respective dates they were filed (or if amended or
superseded by a filing prior to the date of this Agreement, on the date of such
amending or superseding filing), (i) the SEC Reports were prepared in all
material respects in accordance with the requirements of the Securities Act or
the Exchange Act, as the case may be, and (ii) none of the SEC Reports contained
any untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary in order to make the statements made
therein, in the light of the circumstances under which they were made, not
misleading. No subsidiary of the Company is required to file any form, report or
other document with the Commission.

          (b) Each of the consolidated financial statements (including, in each
case, any notes and schedules thereto) contained in the SEC Reports complied as
to form with the

                                        6

<PAGE>

applicable accounting requirements and rules and regulations of the Commission
and was prepared in accordance with United States generally accepted accounting
principles applied on a consistent basis throughout the periods indicated
(except as may be indicated in the notes thereto or, in the case of unaudited
financial statements, as permitted by the rules and regulations of the
Commission), and each presented fairly, in all material respects, the
consolidated financial position of the Company and its consolidated subsidiaries
at the respective dates thereof and their results of operations and cash flows
for the respective periods indicated therein, all in accordance with United
States generally accepted accounting principles (subject, in the case of
unaudited statements, to normal and recurring year-end adjustments which were
not and are not expected, individually or in the aggregate, to be material in
amount).

          (c) Since the most recent of such financial statements, there has been
no material adverse change in the business, affairs, financial position, or
results of operations of the Company and there is no fact or circumstance
required to have been disclosed in an SEC Report that has not been so disclosed.

          SECTION 3.04. No Conflict. The execution, delivery and performance of
the Transaction Documents by the Company do not and will not (a) violate,
conflict with or result in the breach of any provision of its Certificate of
Incorporation or By-laws, (b) conflict with or violate any law, governmental
regulation or governmental order applicable to it or any of its assets,
properties or businesses or (c) conflict with, result in any breach of,
constitute a default (or event which with the giving of notice or lapse of time,
or both, would become a default) under, require any consent under, or give to
others any rights of termination, amendment, acceleration, suspension,
revocation or cancellation of, or result in the creation of any lien or
encumbrance on any of the Company's assets or properties pursuant to, any note,
bond, mortgage or indenture, contract, agreement, lease, sublease, license,
permit, franchise or other instrument or arrangement to which the Company is a
party or by which any of its assets or properties is bound or affected; except
to the extent that any conflict under clause (b) or (c) above would not prevent
or delay the consummation of the transactions contemplated by this Agreement.

          SECTION 3.05. Governmental Consents and Approvals. The execution,
delivery and performance of the Transaction Documents by the Company do not and
will not require any consent, approval, authorization or other order of, action
by, filing with or notification to any governmental authority, except, in the
case of the distributions at the Second Closing, such as are required by the HSR
Act.

                                        7

<PAGE>

                                   ARTICLE IV

                               REPRESENTATIONS AND
                         WARRANTIES OF ORIGINAL MEMBERS

          Each Original Member, severally and not jointly, represents and
warrants to the Company as to such Original Member only as follows:

          SECTION 4.01. Organization and Authority. Such Original Member, to the
extent it is a corporation, limited liability company, partnership or other
Person not an individual, is duly organized, validly existing and in good
standing under the laws of the state of its incorporation or organization and
has all necessary power and authority to enter into the Transaction Document to
which it is a party, to carry out its obligations hereunder and to consummate
the transactions contemplated hereby and thereby. Such Original Member is duly
licensed or qualified to do business and is in good standing in each
jurisdiction in which the properties owned or leased by it or the operation of
its business makes such licensing or qualification necessary, except to the
extent that the failure to be so licensed or qualified would not prevent or
delay the transactions contemplated by the Transaction Documents. The execution
and delivery of the Transaction Documents by such Original Member, the
performance by it of its obligations hereunder and thereunder and the
consummation by it of the transactions contemplated hereby and thereby have been
duly authorized by all requisite action on the part of such Original Member. The
Transaction Documents have been duly executed and delivered by such Original
Member, and the Transaction Documents constitute a legal, valid and binding
obligation of such Original Member, enforceable against such Original Member in
accordance with their respective terms.

          SECTION 4.02. No Encumbrances. (a) Such Original Member owns such
Original Member's membership interest in THINC, the Warrant and, upon receipt,
in any Registrable Stock (as defined in the Registration Rights Agreement)
issuable to it under such Warrant, free and clear of all security interests,
liens, pledges, options, rights of first refusal and other encumbrances.

          (b) Upon the distribution of the New Warrants to the Original Members
pursuant to this Agreement, such Original Member shall own the New Warrant
distributed to it free and clear of all security interests, liens, pledges,
options, rights of first refusal and other encumbrances.

          (c) Such Original Member, upon execution and delivery of this
Agreement, shall own such Original Member's Minority Interest free and clear of
all security interests, liens, pledges, options, rights of first refusal and
other encumbrances.

          SECTION 4.03. No Conflict. The execution, delivery and performance of
each Transaction Document by such Original Member does not and will not (a)
violate, conflict with

                                        8

<PAGE>

or result in the breach of any provision of such Original Member's Certificate
of Incorporation or By-laws (or similar organizational documents), to the extent
it has such, (b) conflict with or violate any law, governmental regulation or
governmental order applicable to such Original Member or any of its assets,
properties or businesses or (c) conflict with, result in any breach of,
constitute a default (or event which with the giving of notice or lapse of time,
or both, would become a default) under, require any consent under, or give to
others any rights pursuant to, any contract, agreement or arrangement by which
such Original Member is bound; except to the extent that any conflict under
clause (b) or (c) above would not prevent or materially delay the consummation
of the transactions contemplated by this Agreement.

          SECTION 4.04. Governmental Consents and Approvals. The execution,
delivery and performance of the Transaction Documents by such Original Member do
not and will not require any consent, approval, authorization or other order of,
action by, filing with or notification to any governmental authority, except
such as are required by the HSR Act.

          SECTION 4.05. Private Placement. (a) Such Original Member understands
that the distribution and issuance of the Common Stock pursuant to the New
Warrants hereunder is intended to be exempt from registration under the
Securities Act pursuant to Section 4(2) of the Securities Act.

          (b) Such Common Stock will be acquired for such Original Member's own
account and without a view to the public distribution thereof except pursuant to
or as permitted under the Registration Rights Agreement.

          (c) Such Original Member is an "accredited investor" as such term is
defined in Regulation D, as amended, under the Securities Act.

          (d) Such Original Member has sufficient knowledge and experience in
financial and business matters so as to be capable of evaluating the merits and
risks of any investment in the Common Stock, and is capable of bearing the
economic risks of such investment, including a complete loss of its investment
in the Common Stock.

                                    ARTICLE V

                              ADDITIONAL AGREEMENTS

          SECTION 5.01. Advisory Board. The Company will promptly form an
Advisory Board (the "Advisory Board") consisting of a representative from each
of the Original Members. The Advisory Board shall meet with the Company's
management at least once each calendar quarter to discuss and provide advice on
the Company's business.

                                        9

<PAGE>

          SECTION 5.02. Registration Rights Agreement. The Company and each of
the Original Members agree that with respect to all shares of Registrable Stock
(as defined in the Registration Rights Agreement), the Registration Rights
Agreement replaces all prior and contemporaneous agreements and supersedes any
registration rights provisions and restrictive legend provisions contained in
the New Warrants. Accordingly, without limitation of the generality of the
foregoing, upon the First Closing, Section 2.5 and Articles VII, VIII and IX of
the New Warrants shall be null and void and no longer in effect.

          SECTION 5.03. Amended and Restated Operating Agreement. Effective at
the First Closing, the Original Members hereby consent to the Amended and
Restated Operating Agreement which provides, among other things, that the
Company shall have a 95.04% interest in THINC, CareInsite Sub shall have a 0.96%
interest in THINC and each Original Member shall have a 1% interest in THINC.

          SECTION 5.04. Tax Treatment. The parties hereto agree (a) unless
otherwise required by law, (A) to report the transactions provided for in
Section 2.01 and 2.05 of this Agreement as the nontaxable distribution of
property pursuant to section 731 of the Internal Revenue Code of 1986, as
amended and (B) not to take any position inconsistent with the foregoing; and
(b) to cooperate with each other with respect to any challenge to such position
by any tax authority. No party to this Agreement believes that the foregoing
position is contrary to law on the date hereof.

          SECTION 5.05. Outstanding Notes. The Company shall repay to each
Original Member the entire outstanding principal amount plus interest that such
Original Member advanced to THINC under the promissory notes listed below:

          (a) (A) the promissory note between THINC and GHI dated July 15, 1998
and (B) the promissory note between THINC and GHI dated November 3, 1998;

          (b) (A) the promissory note between THINC and Empire dated July 15,
1998 and (B) the promissory note between THINC and Empire dated October 30,
1998;

          (c) (A) the promissory note between THINC and HIP dated July 15, 1998;
and (B) the promissory note between THINC and HIP dated October 30, 1998.

          SECTION 5.06. Working Capital Loan Agreement and Promissory Note. On
the date hereof, the Company agrees to assume all of the obligations of THINC
under the Working Capital Loan Agreement dated as of January 1, 1999 and the
Promissory Note dated as of December 10, 1999.

          SECTION 5.07. HSR Act. The Company and THINC will (i) make all
required filings under the HSR Act as soon as practicable but in no event later
than fifteen (15) days after

                                       10

<PAGE>

the First Closing and (ii) request early termination of any waiting period in
connection with such filings.

                                   ARTICLE VI

                                  MISCELLANEOUS

          SECTION 6.01. Survival of Representations and Warranties. The
representations and warranties in this Agreement shall not survive the First
Closing except that the representations and warranties made by each Original
Member in Section 4.01, 4.02 and 4.03 and the representations and warranties
made by the Company in Section 3.01 and 3.04 shall survive until the Second
Closing.

          SECTION 6.02. Termination. This Agreement may be terminated by the
mutual consent and agreement of all of the parties hereto.

          SECTION 6.03. Expenses. Except as otherwise specified in the
Transaction Documents, all costs and expenses, including, without limitation,
fees and disbursements of counsel, financial advisors and accountants, incurred
in connection with this Agreement and the transactions contemplated hereby shall
be paid by the party incurring such costs and expenses, whether or not the First
Closing shall have occurred.

          SECTION 6.04. Notices. All notices, requests, claims, demands and
other communications hereunder shall be in writing and shall be given or made
(and shall be deemed to have been duly given or made upon receipt) by delivery
in person, by courier service, by telecopy or by registered or certified mail
(postage prepaid, return receipt requested) to the respective parties at the
following addresses (or at such other address for a party as shall be specified
in a notice given in accordance with this Section 6.04):

                  (a) if to the Company:

                      CareInsite, Inc.
                      669 River Drive
                      River Drive Center II
                      Elmwood Park, New Jersey  07407
                      Telecopy No.:  (201) 703-3401
                      Attention:  David Amburgey
                      Senior Vice President -- General Counsel

                  (b) if to any Original Member, then to the address or telecopy
         number set forth opposite such Original Member's name on Schedule I
         hereto.

                                       11

<PAGE>

          SECTION 6.05. Headings. The descriptive headings contained in this
Agreement are for convenience of reference only and shall not affect in any way
the meaning or interpretation of this Agreement.

          SECTION 6.06. Modification; Severability. If, in any action before any
court or agency legally empowered to enforce any term, any term is found to be
unenforceable, then such term shall be deemed modified to the extent necessary
to make it enforceable by such court or agency.

          SECTION 6.07. Integration. The Transaction Documents, except as
expressly set forth therein, taken as a whole replace all prior and
contemporaneous agreements and supersedes all prior and contemporaneous
negotiations among the parties with respect to the transactions contemplated
herein and constitutes the entire agreement of the parties with respect to the
transactions contemplated herein.

          SECTION 6.08. Assignment. This Agreement shall not be assigned without
the express written consent of the parties (which consent may be granted or
withheld in the sole discretion of any party). This Agreement shall inure to the
benefit of, and be binding upon, the successors of the parties hereto and the
assignees of the parties hereto, provided such assignment was in compliance with
the terms hereof.

          SECTION 6.09. No Third-Party Beneficiaries. This Agreement shall be
binding upon and inure solely to the benefit of the parties hereto and their
permitted assigns and successors and nothing herein, express or implied, is
intended to or shall confer upon any other Person or entity any legal or
equitable right, benefit or remedy of any nature whatsoever under or by reason
of this Agreement.

          SECTION 6.10. Amendment. This Agreement may not be amended or modified
except by written agreement of each party affected by such amendment or
modification.

          SECTION 6.11. Governing Law. In all respects, including all matters of
construction, validity and performance, this Agreement and the obligations
arising hereunder shall be governed by, and construed and enforced in accordance
with, the laws of the State of New York applicable to contracts made and
performed in such state, without regard to the principles thereof regarding
conflict of laws, and any applicable laws of the United States of America.

          SECTION 6.12. Counterparts. This Agreement may be executed and
delivered (including by facsimile transmission) in counterparts, and by the
different parties hereto in separate counterparts, each of which when executed
shall be deemed to be an original but all of which taken together shall
constitute one and the same agreement.

                                       12

<PAGE>

          SECTION 6.13. Specific Performance. The parties hereto agree that
irreparable damage would occur in the event any provision of this Agreement were
not performed in accordance with the terms hereof and that the parties shall be
entitled to specific performance of the terms hereof, in addition to any other
remedy at law or equity; provided, however, that a party may obtain specific
performance without proof of actual damages or posting of any bond or other
security.

          SECTION 6.14. Nonwaiver; Cumulative Remedies. No course of dealing or
any delay or failure to exercise any right hereunder on the part of any party
shall operate as a waiver of such right or otherwise prejudice the rights,
powers or remedies of such party. No single or partial waiver by any party of
any provision of this Agreement or of any breach or default hereunder or of any
right or remedy shall operate as a waiver of any other provision, breach,
default right or remedy or of the same provision, breach, default right or
remedy on a future occasion. The rights and remedies provided in this Agreement
are cumulative and are in addition to all rights and remedies which a party may
have in law or in equity or by statute or otherwise.

                                       13

<PAGE>

          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed by their respective authorized signatories hereunto duly
authorized as of the date first above written.

                                       CAREINSITE, INC.

                                       By:   /s/   M.P. Rich
                                          --------------------------------------
                                           Name:   M.P. Rich
                                           Title:  Chief Executive Officer

                                       THE HEALTH INFORMATION NETWORK
                                       CONNECTION LLC

                                       By:   /s/   Robert C. Dieterle
                                          --------------------------------------
                                           Name:   Robert C. Dieterle
                                           Title:  President

                                       GNYHA MANAGEMENT CORPORATION

                                       By:   /s/   Lee H. Perlman
                                          --------------------------------------
                                           Name:   Lee H. Perlman
                                           Title:  Chief Vice President and
                                                   Chief Financial Officer

                                       EMPIRE BLUE CROSS AND BLUE SHIELD

                                       By:   /s/   Dr. Michael Stocker
                                          --------------------------------------
                                           Name:   Dr. Michael Stocker
                                           Title:  President

                                       14

<PAGE>

                                       HEALTH INSURANCE PLAN OF GREATER
                                       NEW YORK

                                       By:   /s/   Michael D. Fullwood
                                          --------------------------------------
                                           Name:   Michael D. Fullwood
                                           Title:  Senior Vice President and
                                                   General Counsel

                                       GROUP HEALTH INCORPORATED

                                       By:   /s/   Frank J. Branchini
                                          --------------------------------------
                                           Name:   Frank J. Branchini
                                           Title:  President and Chief
                                                   Executive Officer

                                       15

<PAGE>

                                   SCHEDULE I
                                   ----------

                                    ADDRESSES
                                    ---------

GNYHA Management Corporation
555 West 57th Street, Suite 1500
New York, NY 10019

Telecopy No.: 212-262-6350
Attention:    Lee H. Perlman, Senior Vice President and Chief Financial Officer
              and
              Lori Levinson, Vice President and Associate General Counsel

Empire Blue Cross and Blue Shield
One World Trade Center, 28th Floor
New York, NY 10048

Telecopy No.: 212- 476-2461
Attention:    General Counsel

Group Health Incorporated
441 Ninth Avenue, 8th Floor (34th & 9th)
New York, NY 10001

Telecopy No.: 212-563-8569
Attention:    William Mastro, Senior Vice President and General Counsel

Health Insurance Plan of Greater New York
7 West 34th Street, 12th Floor
New York, NY 10001

Telecopy No.: 212-216-7056
Attention:    Michael D. Fullwood, Senior Vice President, Corporate Secretary
                 and General Counsel

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