Document:

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EXHIBIT 10.58
SECOND AMENDED AND RESTATED PROMISSORY NOTE

                           SECOND AMENDED AND RESTATED
                                 PROMISSORY NOTE

$277,500
October 15, 2001                                           San Diego, California

         FOR VALUE RECEIVED, Randall E. Woods and Nancy Saint Woods, a married
couple residing in the State of California ("BORROWERS"), hereby unconditionally
jointly and severally promise to pay to the order of Corvas International, Inc.,
a Delaware corporation ("LENDER"), in lawful money of the United States of
America and in immediately available funds, the principal sum of $277,500 (the
"LOAN") which shall be due and payable on the dates and in the manner set forth
below. This Second Amended and Restated Promissory Note (this "NOTE") amends and
restates in its entirety that certain Amended and Restated Secured Promissory
Note, dated August 28, 1997, issued by Borrowers to Lender, as amended pursuant
to that certain First Amendment to Amended and Restated Secured Promissory Note,
dated as of September 17, 1998, further amended pursuant to that certain Second
Amendment to Amended and Restated Secured Promissory Note, dated as of July 7,
1999, and further amended pursuant to that certain Third Amendment to Amended
and Restated Secured Promissory Note, dated as of September 12, 2000
(collectively, the "PRIOR LOAN DOCUMENTS").

         1. PRINCIPAL REPAYMENT. The outstanding principal balance of the Loan
shall be repaid on the dates and in the amounts set forth below.

                  REPAYMENT DATE                     REPAYMENT AMOUNT

                  December 14, 2001                  $27,750

                  February 15, 2002                  $55,500

                  May 15, 2002                       $83,250

                  August 15, 2002                    $111,000

In addition, the outstanding principal balance of the Loan may be prepaid in
full at any time without penalty or premium.

         2. PLACE OF PAYMENT. All amounts payable hereunder shall be payable at
the office of Lender, 3030 Science Park Road, San Diego, CA 92121, unless
another place of payment shall be specified in writing by Lender.

         3. APPLICATION OF PAYMENTS. All payments on this Note shall be applied
first to any outstanding costs or expenses of Lender owed or owing by Borrowers
to Lender in accordance with the terms hereof and thereafter to the outstanding
unpaid principal balance of the Loan.

         4. DEFAULT. Each of the following events shall be an "EVENT OF DEFAULT"
hereunder:

            (a) Borrower fails to pay timely any amount due under this Note on
the dates the same becomes due and payable;

                                       1.
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            (b) Borrower files any petition or action for relief under any
bankruptcy, reorganization, insolvency or moratorium law or any other law for
the relief of, or relating to, debtors, now or hereafter in effect, or makes any
assignment for the benefit of creditors or takes any corporate action in
furtherance of any of the foregoing;

            (c) An involuntary petition is filed against Borrower (unless such
petition is dismissed or discharged within sixty (60) days) under any bankruptcy
statute now or hereafter in effect, or a custodian, receiver, trustee, assignee
for the benefit of creditors (or other similar official) is appointed to take
possession, custody or control of any property of Borrower; or

            (d) In the event that Randall E. Woods is no longer an employee of
Lender for any reason.

Upon the occurrence of an Event of Default hereunder, all unpaid principal and
other amounts owing hereunder shall, at the option of Lender, and, in the case
of an Event of Default pursuant to (b), (c) and (d) above, automatically, be
immediately due, payable and collectible by Lender pursuant to applicable law.

         5. WAIVERS; COSTS OF COLLECTION. Each of the Borrowers hereby waives
presentment and demand for payment, notice of dishonor, protest and notice of
protest of this Note, and shall pay on demand all costs and expenses of Lender
in the collection of any amounts under this Note, including, without limitation,
reasonable attorneys' fees, costs and other expenses. The right to plead any and
all statutes of limitations as a defense to any demands hereunder is hereby
waived to the full extent permitted by law.

         6. RELEASE OF SECURITY INTEREST. By acceptance of this Note, Lender
acknowledges and agrees that any security interest previously granted by either
or both Borrowers under any of the Prior Loan Documents in order to secure
Borrowers' obligations under any of the Prior Loan Documents or this Note is
hereby terminated and released.

         7. GOVERNING LAW. This Note shall be governed by, and construed and
enforced in accordance with, the laws of the State of California, excluding
conflict of laws principles that would cause the application of laws of any
other jurisdiction.

         8. SUCCESSORS AND ASSIGNS. The provisions of this Note shall inure to
the benefit of and be binding on any successor to each of the Borrowers and
shall extend to any holder hereof.

                                                BORROWERS

                                                /s/ RANDALL E. WOODS
                                                --------------------------------
                                                Randall E. Woods

                                                /s/ NANCY SAINT WOODS
                                                --------------------------------
                                                Nancy Saint Woods

                                       2.<PAGE>

EXHIBIT 10.1

                     FIRST AMENDMENT TO EMPLOYMENT AGREEMENT

         FIRST AMENDMENT TO EMPLOYMENT AGREEMENT dated as of November 1, 2001,
between SYNERGY 2000, INC., a Delaware corporation (the "Company"), and ELI
DABICH, JR. ("Employee").

         WHEREAS, the Company and the Employee are parties to that certain
Employment Agreement dated as of July 1, 2000 (the "Employment Agreement"), and
now desire to amend the Employment Agreement, subject to the terms and
provisions of this First Amendment.

         NOW, THEREFORE, in consideration of the mutual covenants herein
contained, the parties hereto, intending to be legally bound hereby, agree and
certify as follows:

I. AMENDMENTS

         The Employment Agreement is amended hereby as follows:

                  SECTION 1.01. BASE COMPENSATION. Section 3.01 shall be amended
to provide that effective as of January 1, 2002, Company shall pay Employee and
Employee shall accept, a base salary (the "Salary") at the annual rate of One
Hundred Eighty Thousand Dollars ($180,000). Thereafter, the Company shall pay
Employee at an annualized rate of not less than the rate paid for the
immediately preceding period, subject to annual adjustment, upwards but not
downwards. The salary shall be payable to Employee in accordance with the
Company's standard payroll policies.

                  SECTION 1.02. BONUS. Section 3.02 shall be deleted in its
entirety and substituted therefor shall be a new Section 3.02 as follows:

                  "(a) Guaranteed Bonus. Employee shall be entitled to a
guaranteed bonus payable in cash in an amount equal to twenty-five percent (25%)
of the Salary payable pro-rata commencing with the 2001 calendar year, not later
than March 15, 2002, and annually thereafter, and pro-rated in the event of
commencement, expiration or termination prior to said payment date.

                  (b) Performance Bonus. Employee shall be entitled to incentive
compensation, payable by the Company on a quarterly basis not later than
forty-five (45) days following the end of each calendar quarter, in an amount
equal to a percentage of the Company's actually collected revenues generated by
the Company's operations (but expressly excluding therefrom all revenues
generated by the operations of any of the Company's managing general agency,
insurance company or third-party administration activities), in accordance with
the schedule set forth below:

                  Revenues                         Percentage Bonus Compensation
                  --------                         -----------------------------

                  Up to $10,000,000                             3%
                  $10,000,001-$20,000,000                       2%
                  More than $20,000,000                         1%

The calculation of said quarterly performance bonus payment shall be determined
by the Company's regularly engaged certified public accountants, and shall be
subject to reconciliation on a continuing basis. At Employee's option, Employee
may elect to receive such performance bonus in Company Common Stock or options
to purchase Company Common Stock upon terms mutually determined by Employee and
Company.

                  (c) Employee shall be entitled to such additional bonuses as
may be determined by the Company's Board of Directors."

                  SECTION 1.03. TERMINATION OTHER THAN FOR CAUSE. The
introductory paragraph to Section 4.04 and Section 4.04(a) shall be deleted in
their entirety and substituted therefor shall be a new introductory paragraph to
Section 4.04 and Section 4.04(a) as follows:

                           "SECTION 4.04. TERMINATION OTHER THAN FOR CAUSE OR
                  RETIREMENT. If Employee is terminated for any reason other
                  than as set forth in Sections 4.02 and 4.03 hereof, or if
                  Employee elects to retire after June 30, 2003, then Employee
                  would be entitled to receive compensation and benefits as
                  follows:

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                                    (a) SEVERANCE. Two hundred percent (200%) of
                  the annual Salary at its then current level, payable in a lump
                  sum or over a four (4) year period at the times such salary
                  would otherwise have been payable were Employee to remain
                  employed with Company, as determined by Employee in his sole
                  discretion, and acceleration of vesting of all options. If the
                  Company is unable to make payment entirely in cash, Company
                  shall evidence such obligation by an unsecured demand
                  promissory note convertible into shares of Company's Common
                  Stock on such terms as may be agreed upon by Employee and
                  Company, or at Employee's option, Employee may elect to
                  receive said severance amount in Company Common Stock or
                  options to purchase Company Common Stock. If Employee elects
                  to receive options to purchase Company Common Stock, then all
                  such options shall be vested immediately and Company shall
                  take such steps to register such securities as promptly as
                  practicable in a registration statement pursuant to applicable
                  Federal and state securities laws; and"

II. GENERAL PROVISIONS

                  SECTION 2.01. CONSTRUCTION. This Agreement shall be construed
in accordance with the laws of the State of California. In all matters of
interpretation, whenever necessary to give effect to any provision of this
Agreement, each gender shall include the others, the singular shall include the
plural, and the plural shall include the singular. The titles of the paragraphs
of this Agreement are for convenience only and shall not in any way affect the
interpretation of any provision of this Agreement.

                  SECTION 2.02. COUNTERPARTS. This Agreement may be executed in
two or more counterparts, which, taken together, shall constitute the whole of
the Agreement as between the parties. Each party hereto shall be authorized to
rely upon the signatures of all of the parties hereto which are delivered by
facsimile as constituting a duly authorized, irrevocable, actual, current
delivery of this Agreement with original ink signatures of each person and
entity; PROVIDED, HOWEVER, that each party hereto that delivers such facsimile
signatures to another party hereto, covenants and agrees that it shall deliver
an executed original of the same to the party so receiving the previous
facsimile signatures within five (5) days after delivery of such facsimile
signatures.

                  SECTION 2.03. CONTINUED EFFECTIVENESS OF EMPLOYMENT AGREEMENT.
Except as expressly amended hereby, the Employment Agreement shall continue in
full force and effect in accordance with the provisions thereof. As used in the
Employment Agreement, the term "Agreement" shall, unless the context otherwise
specifically requires, mean the Employment Agreement as amended by this First
Amendment.

         IN WITNESS WHEREOF, the parties hereto have hereunto executed this
First Amendment.

                               SYNERGY 2000, INC.,

                               By: /S/ JEANETTE T. SMITH
                                   Jeanette T. Smith, Executive Vice President

                                   /S/ ELI DABICH, JR.
                                   ELI DABICH, JR.

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