Document:

Exhibit 10.40

 

 

 

LEASE TERM SHEET

 

THIS LEASE TERM SHEET is made a part of the attached Lease Agreement between Landlord
and Tenant. Use of the following capitalized terms (indicated in bold type) in this Lease shall be deemed a reference to the information
set out below.

 

	 •	Landlord:	 	Keystone-Centennial II, LLC
	 	 	 	a North Carolina limited liability company
	 	 	 	5410 Trinity Road, Suite 215
	 	 	 	Raleigh, NC 27607
	 	 	 	Attn:  J. Patrick Gavaghan, Manager
	 	 	 	Email: jpgavaghan@kscdevelop.com
	 	 	 	 
	 •	Managing Agent:	 	Keystone Corporation
	 	 	 	a North Carolina Corporation
	 	 	 	5410 Trinity Road, Suite 215
	 	 	 	Raleigh, NC 27607
	 	 	 	Attn: Jim Little
	 	 	 	Email: jlittle@kscdevelop.com
	 	 	 	 
	 •	Tenant:	 	Argos Therapeutics, Inc.
	 	 	 	a Delaware corporation

 

	After Commencement Date:	 	Before Commencement Date:	 	Emergency Contact:
	 	 	 	 	 
	1010 Main Campus Drive	 	4233 Technology Drive	 	Name: Randal Goller
	Suite ____	 	Durham, NC  27704	 	Tel: 919-641-2276
	Raleigh, North Carolina 27607	 	Attn: Jeffrey D. Abbey	 	Email: rgoller@argostherapeutics.com
	Attn: Jeffrey D. Abbey	 	Email: jabbey@argostherapuetics.com	 	 
	Email: jabbey@argostherapuetics.com	 	With a copy to the General Counsel	 	 

 

	 •	Landlord Parties:  Landlord, Managing Agent, and their respective officers, directors, managers, employees, and owners.
	 	 	 	 	 
	 •	Tenant Parties:  Tenant and its officers, directors, employees, and owners.
	 	 	 	 	 
	 •	Brokers:	 	 	 
	 	- Landlord's Broker:  CBRE (Lee Clyburn)
	 	- Tenant's Broker: N/A
	 	 	 	 	 
	 •	Landlord's Lender:  As of the date of determination, the beneficiary of any deed of trust which is a first lien against Landlord's interest in the Building.
	 	 	 	 	 
	 •	NCSU:  North Carolina State University
	 	 	 	 	 
	 •	Campus:  The NCSU Centennial Campus located in Raleigh, NC
	 	 	 	 	 
	 •	Execution Date:   The latest date of execution by Landlord and Tenant as reflected on the signature page of this Lease.
	 	 	 	 	 
	 •	Land:  Being all of Lot 1, containing 2.612 acres, more or less, as shown on that plat recorded in Book of Maps 2015, Page 145, Wake County Registry.
	 	 	 	 	 
	 •	Building:  That building located on the Land consisting of approximately 104,998 rentable square feet, identified as "Center for Technology and Innovation", and having an address of 1010 Main Campus Dr., Raleigh, NC. As used in this Lease, the term "Building" shall also include the Land and all other improvements, now located or subsequently constructed, on the Land.
	 	 	 	 	 

 

     

     

    

 

	 •	Premises: 40,420 rentable square feet (approx.) in the Building consisting of
	 	      	 	 	 
	 	 	-- 31,532 rentable square feet (approx.) on the third floor, to be used as lab space
	 	      	-- 8,314 rentable square feet (approx.) on the second floor, to be used as office space
	 	      	-- 574 rentable square feet (approx.) on the ground floor, to be used for deliveries and shipments
	 	 	 	 	 
	 	all as outlined on Exhibit A attached to this Lease. 
	 	 	 	 	 
	 •	Parking Spaces:  100 unreserved parking spaces (the "Minimum Number"), plus one additional unreserved parking space per permanent employees and long-term service providers (i.e,, service providers engaged for more than 30 days) over 100, (up to a maximum of 161 spaces) within the parking deck constructed as part of the Building and/or in the surface parking lot(s) serving the Building and located on the Land. To receive parking spaces over the Minimum Number, Tenant must give Landlord not less than 120 days advance written notice of the need for the additional space(s) and a certification of the number of permanent employees projected to be employed by Tenant as of the end of that 120-day period.
	 	 	 	 	 
	 •	Permitted Use: Research laboratory and manufacturing operations related to cancer-related drugs and ancillary office use, along with other lawful uses reasonably related to or incidental to such specified use.
	 	 	 	 	 
	 •	Improvements:	 	 
	 	-  Building Improvements:   Described on Exhibit C attached
	 	-  Tenant Upfit: The interior space improvements for the Premises as reflected in the Approved Plans & Specs.
	 	-  Plans & Specs Deadline:  
	 	 	For Phase I:  	January 15, 2017
	 	 	For Phases II & III:	March 1, 2017
	 	-  Budget Approval Deadline: 15 days after the plans and specifications for the Tenant Upfit for the applicable Phase are mutually approved.
	 	-  Tenant Upfit Budget:  The construction budget for the Tenant Upfit.
	 	    	-  Tenant Upfit Allowance:  $1,616,800.00
	 	 	-  Phase I Space: The 1,484 rentable square feet (approx.) and 61 rentable square feet (approx.), both located on the third floor of the Building, and 283 rentable square feet (approx.) located on the second floor of the Building, all as more particularly shown on Exhibit A attached.
	 	-  Phase II Space:  The 8,031 rentable square feet (approx.) of office space located on the second floor of the Building; 16,219 of rentable square feet (approx.) of manufacturing space located on the third floor of the Building; and 574 rentable square feet (approx.) of storage space located on the ground floor of the Building, all as more particularly shown on Exhibit A attached.
	 	-  Phase III Space: 13,768 of rentable square feet (approx.) of "Level 7 Clean Space" located on the third floor of the Building and more particularly shown on Exhibit A attached.
	 	 	 	 	 
	 •	Construction Schedule: (See Exhibit  E attached)
	 	 	 	 	 
	 •	Term: From Commencement Date through Expiration Date.
	 	-  Commencement Date:  The date on which Landlord delivers possession of the Phase I Space to Tenant following Substantial Completion of the Tenant Upfit for that Phase.
	 	-  Rent Commencement Date:  The date on which Landlord delivers possession of the Phase II to Tenant following Substantial Completion of the Tenant Upfit for that Phase.
	 	-  Expiration Date: 123 months from the end of the Rent Commencement Date 
	 	-  Renewal Option: As described in Exhibit B
	 	 	 	 	 
	 •	Rent:	 
	 	-  Base Rent: Described in Exhibit F attached
	 	-  Per Diem Rent: $2,920.31

 

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	 	-  Rent Abatement: 50% of the Base Rent otherwise due shall abate during the first three months following the Rent Commencement Date; a total of $131,413.75 in Rent Abatement.
	 	-  Additional Rent (TICAM): Described in Section 5.3 (This is a NNN Lease.)
	 	-  Initial Advance Payment: $17,791.40 (The parties acknowledge that this is an estimated amount.)
	 	-  Tenant's Proportionate Share: The percentage obtained by dividing the rentable square feet of the Premises by the rentable square feet of the Building, as those figures may vary from time to time resulting from physical changes in the size of the Premises and/or Building, or changes in the character of space within the Building, which, as of the Rent Commencement Date is 38.51%. 
	 	-  Holdover Rent Multiple:  1.5 
	 	 	 	 	 
	 •	Security Deposit Amount:  Subject to the provisions of Exhibit G, $2,400,000.00
	 	 	 	 	 
	 •	Rules & Regulations:  The rules and regulations described on Exhibit H attached, as may be subsequently supplemented and modified by Landlord as provided in this Lease.
	 	 	 	 	 
	 •	Insurance:	 	 
	 	- Tenant Liability Coverage: $10,000,000.00 Combined Single Limit;
	 	-  Landlord Liability Coverage: $10,000,000.00 Combined Single Limit
	 	-  Business Interruption Insurance Coverage: 12 months Base Rent  
	 	 	 	 	 
	 •	Interest Rate: 12.0% per annum
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	 •	Guarantor(S):  N/A
	 	 	 	 	 
	 •	Exhibits:	A - Premises Description
	 	 	 	B - Renewal Option
	 	 	 	C - Building Improvements
	 	 	 	D - Tenant Upfit
	 	 	 	E - Construction Schedule
	 	 	 	F - Base Rent 
	 	 	 	G - Letter of Credit Terms & G-1 Form of Letter of Credit
	 	 	 	H - Rules and Regulations
	 	 	 	I - Itemized Inventory of Hazardous or Toxic Materials
	 	 	 	J - Radioactive Materials/Radioactive Equipment Requirements
	 	 	 	K - Lease Memorandum
	 	 	 	L - Generator
	 	 	 	M - Shared Utilities
	 	 	 	N - Tenant's List of Personal Property

 

 

		

 

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Tenant's execution of this Lease shall be deemed an offer to lease and shall not
be deemed accepted by Landlord until this Lease is executed by Landlord and a counterpart original returned to Tenant.

 

 

 

 

 

 

 

 

 

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LEASE AGREEMENT

 

THIS LEASE AGREEMENT (this "Lease") is entered
into as of the Execution Date between Landlord and Tenant. Landlord, in consideration of the rents and covenants to be kept and
performed by Tenant, leases to Tenant that certain property and improvements, more specifically described below, upon the following
terms and conditions:

 

1. DEFINITIONS
& RULES OF CONSTRUCTION.

 

1.1. Definitions. In addition to other terms defined
in the Lease Term Sheet and elsewhere in this Lease, the following capitalized words and phrases shall have the indicated meanings
in this Lease unless the context otherwise requires:

 

"ADA" refers to Title III of The Americans
with Disabilities Act, Public Law 101-336 (July, 1990).

 

"Advance Payments" refers to the monthly
payments of estimated Additional Rent paid by Tenant to Landlord as described in Section 5.3.3.

 

"Approved Plans & Specs" is defined Exhibit
D.

 

"Alterations" means alterations, additions,
or improvements in or to the exterior or interior of the Premises.

 

"Bidder" is defined Exhibit D.

 

"Change Order" is defined Exhibit D.

 

"Common Areas" refers those common areas
of the Building necessary for ingress, egress, and parking. These areas include drives, sidewalks, and parking areas, along with
any other areas which Landlord may, but is not obligated to, designate for common use by tenants.

 

"Deed of Trust" refers to the Landlord's
Lender's security instrument, as of the date of determination.

 

"Environmental Laws" means any federal, state,
or municipal law, ordinance, or regulation, now or subsequently enacted, relating to the existence, use, generation, storage, transportation,
or disposal of Hazardous Substances and/or other environmental conditions.

 

"Expenses" means all direct costs of operation
and maintenance of the Building as determined by GAAP, including those described in Section 5.3.1.

 

"Event of Default" is defined in Section
17.1.

 

"GAAP" refers to generally accepted accounting
principles, consistently applied.

 

"Ground Lease" that "Ground Lease
Agreement", dated August 13, 2015, entered into by The Board of Trustees of the Endowment Fund of North Carolina State
University, as ground lessor, and the Landlord, as tenant.

 

"Hazardous Substances" means flammables,
explosives, radioactive materials, asbestos, polychlorinated biphenyls (PCBs), chemicals known to cause cancer or reproductive
toxicity, pollutants, contaminants, hazardous wastes, toxic substances or related materials, petroleum and petroleum products,
biological and medical wastes, samples, or substances, and substances declared to be hazardous or toxic under any law or regulation
now or hereafter enacted or promulgated by any governmental authority. "Hazardous Substances" shall also include
any mold, fungus, or spores, if such mold, fungus, or spores poses a risk to human health or the environment, whether or not such
is classified as a "hazardous material" under any Environmental Laws.

 

     

     

    

 

"Insolvency Proceeding" refers to: (i) Tenant’s
assignment for the benefit of creditors; (ii) Tenant’s written admission of an inability to pay its debts as they become
due or failure, generally, to pay its debts as they become due; (iii) Tenant’s filing or consenting to the filing of any
petition in bankruptcy, reorganization, or other proceeding under the Federal Bankruptcy Act or any other law, now or subsequently
in effect, relating to the reorganization or the arrangement or readjustment of its debts; (iv) Tenant’s consent to the appointment
of a receiver, liquidator, or trustee for any of its properties; (v) the entry of a court order appointing a receiver, liquidator,
or trustee for all or a substantial part of Tenant’s property; or (vi) any other voluntary or involuntary act of insolvency
by Tenant.

 

"Letter of Credit" is defined in Section
6.1.

 

"Phase" refers to the Phase I
Space, the Phase II Space, and/or the Phase III Space as the context requires.

 

"Reasonable attorneys' fees" refers to those
fees actually charged by the attorney based upon time actually spent, at customary and reasonable charges normally incurred for
those type of services, as opposed to any statutory presumption which may then be in effect.

 

"Security Deposit" is defined in Section
6.1.

 

"Statement" refers to Landlord's itemized
statement of any Additional Rent due from Tenant.

 

"Successor" refers to the successor to Landlord's
interest in the Premises, whether by sale, lease, foreclosure, or in any other manner.

 

"Upfit Costs" refers to the costs and expenses
incurred in designing and/or constructing the Tenant Upfit.

 

1.2. Rules of Construction. The following rules shall
be followed in interpreting the provisions of this Lease: (a) all attached Exhibits are incorporated into this document by reference
and are made a part of this Lease. The inadvertent failure to attach any Exhibit described in this Lease to the fully executed
Lease shall not render this Lease invalid, incomplete, or ineffective in any way. Upon notice from one party to the other, Landlord
and Tenant shall cooperate in good faith to provide any missing information regarding the missing Exhibit, and each shall append
the missing Exhibit to their respective executed original of this Lease. The term "Lease" shall be deemed to include
all such Exhibits and any other documents expressly incorporated, by reference, into this Lease; (b) this Lease constitutes the
entire and exclusive agreement between the parties on the Transaction and supersedes any and all prior agreements, arrangements,
and understandings, whether written, oral, electronic, or otherwise, between the parties on the Transaction; (c) all words and
phrases shall be construed to include the singular or plural number, and the masculine, feminine, or neuter gender, both as the
context requires; (d) the captions and headings are for convenience only and in no way define, limit, or describe the scope or
intent of any provisions of this Lease; (e) all references to "Sections" are references to sections of this Lease
unless some other reference is established; (f) the term "include" or "including" shall be deemed
to mean "without limitation"; (g) this Lease may be executed in any number of counterparts with the same effect
as if all parties had signed the same document. All counterparts shall be construed together and shall constitute one Lease; (h)
any statutory reference in this Lease shall include a reference to any successor to such statute and/or revision thereof; (i) any
reference to an agreement shall, unless otherwise indicated, include a reference to such agreement as amended, restated, or otherwise
modified from time to time; (j) this Lease shall be construed as having been drafted by both parties, jointly, and not in favor
of or against one party or the other; (k) the term "person" and words importing persons shall include firms, associations,
partnerships, joint ventures, trusts, corporations, limited liability companies, public and governmental bodies, and other legal
entities, agencies, or instrumentalities, as well as natural persons; (l) this Lease shall be deemed executed and completed in
North Carolina and, along with all matters (including torts) relating to or arising out of this Lease or the relationship of the
parties under this Lease, shall be construed in accordance with the laws of North Carolina, without giving effect to its conflict
of laws principles; (m) All accounting terms not otherwise specifically defined in this Lease shall be construed in accordance
with GAAP; and (n) whenever an action to be taken under this Lease must be "reasonably" approved or is subject
to "reasonable" consent or approval, "reasonably" and "reasonable" shall, in
each instance, mean such consent/approval shall not be unreasonably withheld, conditioned, or delayed. If a party's consent/approval
is not so qualified, that party may withhold its consent/approval in its sole discretion.

 

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2. PREMISES.

 

2.1. Premises. The property leased to Tenant is the
Premises located in the Building as described in the Lease Term Sheet. Unless specifically provided to the contrary elsewhere in
this Lease, the term "Premises" shall consist of only that interior space located within the perimeter described
on Exhibit A (including the interior portions of the wall surfaces, ceiling and floor). The Premises shall not include
the roof, roof membrane or any exterior wall surfaces (other than exterior glass), and, except as may otherwise be provided in
this Lease, Tenant shall have no right to occupy or otherwise use those areas except as contemplated by the Tenant Upfit or as
otherwise reasonably approved by the Landlord.

 

2.2. Common Area. The Premises are leased to Tenant
together with a non-exclusive license to use the Common Areas. Unless specifically provided elsewhere in this Lease, Tenant shall
have no parking spaces marked exclusively for its use and shall observe restricted parking areas designated by Landlord; provided,
however that Landlord shall not oversubscribe parking within the parking areas serving the Building nor otherwise do or permit
anything that would unduly interfere with the express parking rights granted to Tenant herein and shall not grant reserved parking
to any other tenant without granting commensurate reserved parking to Tenant. Landlord does not grant any easement for light, air,
or view. Provided they do not materially affect Tenant's use of the Premises, access or parking rights, Landlord, from time to
time, may change the size, location, nature, and use of any of the Common Areas, convert Common Areas into leasable areas, construct
additional parking facilities (including parking structures) in the Common Areas, and increase or decrease Common Area land and/or
facilities. Landlord shall use all commercially reasonable efforts to minimize any impact on Tenant's business operations in the
Premises, access, and/or parking rights during Landlord's exercise of the foregoing rights. Tenant acknowledges that such activity
may result in inconvenience to Tenant. Tenant shall not unreasonably interfere with the rights of Landlord, other tenants or any
other person entitled to use the Common Areas for the purposes for which those areas were designed.

 

2.3. Right to Relocate. Intentionally Omitted

 

3. TERM.

 

3.1. Duration. Subject to a prior termination as provided
in this Lease, this Lease shall be binding and effective as of the Execution Date and shall remain in effect for the Term.

 

3.2. Early Occupation. Provided it does not cause undue
interference or delay in Landlord's completion of the Tenant Upfit, Tenant may (prior to the Commencement Date and without incurring
any liability for payment of Rent or other charges), place and install its personal property, equipment, and trade fixtures, in
any part of the Premises, at Tenant's sole risk and expense. All other provisions of this Lease shall be applicable to this early
occupation by Tenant. Occupation pursuant to this subsection shall not be deemed "taking possession" by Tenant.

 

3.3. Early Termination. Landlord and Tenant acknowledge
that: (i) NC State Non-Woven Fabrics Institute (the "Institute") will be a tenant in the Building, and
that the Building has been designed to accommodate substantial industrial equipment that will be utilized by that tenant; and (ii)
Tenant needs additional time to determine whether the noise and/or vibrations generated by the Institute's operations will prevent
it from getting the required FDA approval for its intended use of the Premises (the "FDA Approval"). To
assist Tenant in making that determination, Landlord shall promptly make all sound testing reports, architectural and engineering
designs, and similar materials it has for the Building (including the Institute's space) to Tenant. Notwithstanding anything in
this Lease to the contrary, if Tenant, in its reasonable discretion, determines that the noise and/or vibrations generated by the
Institute's operations will prevent Tenant from getting the FDA Approval, Tenant may terminate this Lease by giving written notice
of termination to Landlord before February 1, 2017. Upon a timely termination of this Lease by Tenant: (i) Landlord shall return
the Security Deposit to Tenant; and (ii) Tenant shall be obligated to reimburse Landlord for all costs incurred to the date of
Landlord's receipt of that termination in designing and engineering the plans for, and constructing the Tenant Upfit in the Premises
(collectively, the "LL Incurred Costs"). Promptly after receipt of the notice of termination, Landlord
shall send Tenant a written itemization (with reasonable supporting documentation as requested by Tenant) of the LL Incurred Costs
to be reimbursed. Reimbursement of the LL Incurred Costs shall be due from Tenant within 30 days of its receipt of the itemization
of the LL Incurred Costs. Any dispute with respect to the LL Incurred costs to be reimbursed shall be resolved by arbitration as
contemplated under Section 31.8.

 

    	 	3

     

    

 

3.4. Option to Renew. Tenant shall have two option
to renew this Lease as provided in Exhibit B attached.

 

4. CONDITION AND USE OF PREMISES.

 

4.1. Condition of Premises. Except as expressly provided
in this Lease (e.g. Section 7.4), none of the Landlord Parties or Landlord's agents has made any representations
with respect to the Premises, the Building, or any other tenants (past, present, or future) that are not set forth in this Lease.
Tenant represents that it has made or will, prior to occupancy, make its own inspection of and inquiry regarding the condition
of the Premises and the Building and is not relying on any representations of the Landlord Parties or Landlord's Broker that are
not set forth in this Lease. Except as otherwise provided in this Section taking possession of the Premises by Tenant shall be
conclusive evidence, as against Tenant, that Tenant accepts the Premises and the Building (including the Common Areas) "as
is"; that the Premises contains the number of rentable square feet reflected in the Lease Term Sheet; and that the Premises
and the Building (including the Common Areas) were in good and satisfactory condition at the time of taking possession and suitable
for the Permitted Use. Notwithstanding the preceding to the contrary, Landlord represents that, as of the Commencement Date, to
the best of its knowledge: (i) the Building (including Phase I Space) and Common Areas will comply with all applicable legal requirements
of any governmental or quasi-governmental body; provided that Landlord makes no representations as to any compliance with any US
FDA regulations ; (ii) neither the Premises nor the Building contains any Hazardous Substances in violation of any Environmental
Laws, (both as later defined); and (iii) all Building systems will be in good working order and condition as of the Rent Commencement
Date. This representation shall be deemed repeated by Landlord for the applicable Phase as of that Phase's delivery date.

 

4.2. Use of Premises. The Premises shall be used and
occupied by Tenant for the Permitted Use and for no other purpose. Tenant may not use any of the Premises for any illegal or unlawful
purpose and may not cause or permit a nuisance to be created or maintained on the Premises including noises of such a level as
to disturb others in the Building. Upon discovering any unlawful use within the Premises, Tenant shall immediately take action
to halt that activity. Tenant will be responsible for resolving any EMF interference or wireless internet service interference
caused by it, and, upon Landlord's request, may be required to password-protect its Wi-Fi service. Landlord shall similarly require
any other tenant or occupant of the Building to resolve any EMF interference or wireless internet service interference caused by
the installations of such other tenant or occupant and affecting Tenant's systems. Tenant's use of the Premises and the Common
Areas shall comply with the Rules & Regulations and all use restrictions applicable to subtenants under the terms of the Ground
Lease. Tenant's use may not increase the fire insurance premiums on the Building or make that insurance unavailable to Landlord.
Tenant's use of the Premises shall also be subject to the Rules & Regulations. Landlord shall not conduct building operations
and shall not permit another tenant to use the Building for any purpose that would interfere with Tenant’s ability to obtain
or maintain U.S. FDA approval to manufacture on the Premises.

 

4.3. Compliance. Throughout the Term of this Lease,
Tenant shall comply with:

 

(a) all applicable legal requirements of any governmental or quasi-governmental
body (including City, County, State, and Federal boards) having jurisdiction respecting any operation conducted or any equipment
installations or other property placed upon, in, or about the Premises;

 

(b) the terms of the Ground Lease applicable to subtenants and all
rules and regulations of NCSU and the NCSU Public Safety Office in effect during the Term (including all hazardous materials regulations,
signage regulations, and other restrictions, guidelines or regulations affecting the Campus).

 

Tenant and any subtenant of the Premises shall adhere to all reasonable emergency plans
(including plans relating to fire, safety, events of terrorism, and any other contingencies) of NCSU. Tenant's compliance shall
be for the benefit of Landlord and NCSU. Upon discovering any violation of this Section, Tenant shall promptly take all necessary
remedial action.

 

    	 	4

     

    

 

4.4. ADA Compliance.  Landlord warrants that, to the
best of its knowledge, as of the Commencement Date, the Phase I Space, the Common Areas, and the Building shall comply with all
applicable laws and regulations dealing with access by individuals with disabilities, including the ADA. This representation shall
be deemed repeated by Landlord for the applicable Phase as of that Phase's delivery date. Thereafter, to the extent that: (i) the
Premises do not comply with the ADA; (ii) such non-compliance relates to or arises out of Tenant's particular use, operations,
or Alterations (as defined below); and (iii) modification of the Premises is required in order to comply with law, Tenant shall,
at its sole expense, take all reasonable steps to modify the Premises to comply with the ADA. Otherwise, Landlord shall, subject
to the provisions of Section 4.3, be responsible for keeping the Premises, the Common Areas, and the Building (exclusive
of Alterations) in compliance with the ADA.

 

4.5. Licenses. Throughout the Term of this Lease, Tenant
shall obtain and maintain all licenses, permits, and other governmental approvals necessary for the operation of the business conducted
by it at the Premises.

 

4.6. Building Changes/Additions. Landlord may at any
time and without liability to Tenant construct additional buildings and change, alter, remodel, or remove any of the improvements
in the Common Areas, and install in or through the Premises any wiring, piping, ducts, or conduits necessary for the service of
the Premises, or other buildings in the Building. Notwithstanding the foregoing, all such wiring, piping, ducts or conduits shall
be installed behind walls, under floors, and/or above ceilings in the Premises and shall not interfere with installations previously
made by Tenant in such areas nor reduce the usable square footage of the Premises. Further, Landlord shall not materially impair,
and shall use all commercially reasonable efforts to minimize any impact on, Tenant's business operations in the Premises during
and as a result of Landlord's exercise of the foregoing rights, including coordinating any necessary shut-down or interruption
in utilities with Tenant to the fullest extent possible.

 

5. RENT.

 

5.1. Base Rent. Commencing on the Rent Commencement
Date and continuing for the remainder of the Term, Tenant shall pay to Landlord the Base Rent set out in Exhibit F.
The Installment Amounts of Base Rent (as reflected in Exhibit F), as well as payments of Additional Rent, shall be
payable without previous demand, and without offset or deduction, except as otherwise set forth in this Lease, in advance, on or
before the first day of each month, at the office of Landlord at the address given in the Lease Term Sheet or such other address
as Landlord notices Tenant in writing. If the Rent Commencement Date is a day other than the first day of the month or if the Term
ends on a day other than the last day of the month, Base Rent for any partial month of the Term shall be pro-rated on a per diem
basis.

 

5.2. Rent Abatement.  The Rent Abatement is being given
by Landlord in anticipation that Tenant faithfully fulfills all of its obligations for the first 123 months of the Term. Upon an
Event of Default occurring during that period, the Rent Abatement shall be forfeited and Landlord shall be entitled to recover
the Rent Abatement from Tenant, in addition to other rights and remedies available to it as a result of the Event of Default.

 

5.3. Additional Rent.  Tenant shall pay Landlord Additional
Rent in amounts and in the manner as described below:

 

5.3.1. Expenses. "Expenses"
shall include all direct costs of operation and maintenance of the Building as determined by GAAP and shall include by way of illustration:

 

(i) Taxes. Amounts paid by Landlord for real estate
taxes, special assessments, or any governmental charges which may be levied or assessed against the Building. "Taxes"
shall specifically exclude Landlord's income and/or franchise taxes and tax penalties, and/or any other taxes that are personal
to Landlord, such as inheritance, estate or gift taxes.

 

    	 	5

     

    

 

(ii) Utilities. Amounts paid by Landlord for electricity,
heating and air conditioning, telephone in the elevator, and other utilities for the Common Areas of the Building. Amounts paid
by Landlord for water and sewage services used at the Building, including the Common Areas, the Premises, and all other tenant
space unless separately metered or specifically attributable to another tenant.

 

(iii) Insurance. Amounts paid by Landlord for all premiums
for insurance required by this Lease or otherwise deemed by Landlord to be reasonable property and liability insurance coverage
with respect to the Building.

 

(iv) Maintenance. The reasonable cost of wages, including
associated payroll taxes, insurance and fringe benefits, of persons employed by Landlord in connection with the operation or management
of the Building, with such costs allocated to the Building in proportion to share of such person(s)’ overall time allocated
to the Building, including management personnel at or below the level of Building manager, secretaries, security guards (if any),
janitors, carpenters, painters, laborers and other office, maintenance, security, janitorial or general cleaning personnel. The
reasonable cost of services furnished by independent contractors with respect to the operation, repair, maintenance, security or
cleaning of the Building. The reasonable cost of materials, tools and equipment, including toilet room supplies, fluorescent and
incandescent lamps, filters, cleaning supplies and maintenance items, purchased by Landlord in providing Services (as later defined).

 

(v) Operating Expenses. Reasonable amounts paid by
Landlord for all direct costs of operations and maintenance (not otherwise specified above) as determined by GAAP. These shall
include the following costs by way of illustration, but not limitation: Payroll expense associated with personnel directly providing
operational and maintenance services, fuel, security, management fees (not to exceed 5% of base rents payable to Landlord by tenants
and occupants of the Building in any given year), legal and professional fees (except as specifically excluded), maintenance costs
(including Building and grounds), plumbing, heating, electrical, air conditioning and cleaning (including janitorial services,
supplies, rubbish and snow removal).

 

"Expenses" shall specifically exclude costs incurred for making installations,
replacements or alterations to the Building which under GAAP are properly classified as capital expenditures; costs of correcting
latent or structural defects in the Building (including defects in the roof or Building systems, such as the HVAC), Common Areas
or Premises; costs of capitalized equipment; depreciation on the Building or any Building equipment or systems; ground lease rental
payments, loans, and/or mortgage principal and interest; expenses associated with mortgaging, refinancing or selling the Building
or incurred in connection with a dispute with any lender or purchaser of the Building (including legal or professional fees incurred
in connection with such); costs of negotiating or enforcing leases or incurred in connection with disputes with any tenants or
occupants of the Building (including legal or professional fees incurred in connection with such ); marketing and leasing expenses
including broker commissions; Landlord's "overhead" or general administrative expenses; expenses otherwise reimbursable
by specific tenants or occupants of the Building or other third parties or through insurance proceeds; expenses for the purpose
of renovating or restoring any tenant space in the Building; charitable or political contributions of Landlord; costs of executive
compensation (including salaries or benefits of any kind) for any personnel above the level of Building manager; costs to operate
any commercial concession in the Building; costs of paintings, sculptures or artwork for the Building; tax penalties or interest
charged as a result of Landlord's failure to timely pay any amounts due or resulting from Landlord's negligence or willful misconduct;
costs of investigating or remediating Hazardous or Toxic Materials at the Building (provided such shall not limit Landlord's rights
under Section 29); and any costs attributable to services (or above-standard service levels) that are not generally
provided or available to all tenants and occupants of the Building, or that specifically are not available to Tenant, or which
are generally available only at additional expense.

 

5.3.2. Gross Up.  In any calendar year in which the
leasable area of the Building is not fully occupied for the entire year, the Expenses (other than Taxes and Insurance (described
above) and any other Expenses that do not vary with the level of occupancy) shall be "grossed up" as if the Building
were 100% occupied for the entire calendar year. The gross up shall be based upon Landlord's reasonable projections of the variable
Expenses expected to be incurred if the Building were totally occupied for the entire calendar year, as determined under GAAP and
in accordance with sound commercial office building management practices. Landlord shall have the duty during the Term to be reasonable
in its selection of persons providing services to the Building, taking into consideration the services required and their cost
within the Raleigh, North Carolina area.

 

    	 	6

     

    

 

5.3.3. Payment.  For each calendar year during the
Term, Tenant shall pay to Landlord, as Additional Rent, Tenant's Proportionate Share of the Expenses incurred by Landlord in that
calendar year. If the Term does not cover an entire 12 months for a particular calendar year, the amount of Additional Rent due
from Tenant for that calendar year will be adjusted proportionately on a per diem basis. From the Rent Commencement Date through
the end of that calendar year, Tenant shall pay the Initial Advance Payment of Additional Rent each month. Thereafter, with each
Base Rent payment during the Term, Tenant shall pay Landlord an Advance Payment which shall equal one-twelfth of the amount of
Tenant's Proportionate Share of the Additional Rent, if any, anticipated for the upcoming calendar year as a credit against Additional
Rent due for that calendar year. At any time during the calendar year Landlord may increase the amount of the monthly Advance Payments
for that year to account for unexpected increases in Expenses by providing at least 30 days' prior written notice to Tenant; provided
that (i) Landlord shall not make more than one such mid-year adjustment in any calendar year, (ii) Landlord must have a reasonable
basis for such increase, and (iii) such increase shall not exceed 10% of the Advance Payments originally set for that year. All
Advance Payments shall be credited to Tenant's account for the applicable calendar year. Within 120 days after the end of each
calendar year, Landlord shall send Tenant a Statement as to the Additional Rent due for the preceding calendar year, which shall
include a reasonable description of any gross up calculations and all Advance Payments to be credited to Tenant. Any deficiency
in the Advance Payments shall be noted in the Statement and paid by Tenant within 30 days after it receives or is deemed to have
received the Statement. Any excess in the Advance Payments shall be applied to the Additional Rent obligation otherwise due in
the ensuing calendar year, or, if this Lease has been terminated or has expired and the excess has not been otherwise applied by
Landlord to cure an Event of Default (as defined below), that excess shall be refunded to Tenant with the Statement for that year.
Tenant's obligation to pay Additional Rent and Landlord's obligation to refund any excess Advance Payments, as the case may be,
accruing through the date of expiration or any early termination of this Lease shall survive that expiration/termination.

 

5.3.4. Inspection of Books and Records. At any reasonable
time, but no more than once in each calendar year, Tenant shall be entitled to inspect all of Landlord's records necessary to reasonably
satisfy itself that all charges have been correctly allocated to Tenant. Tenant must give Landlord at least five business days'
prior written notice before exercising this inspection right. The inspection shall be conducted at Landlord's business office during
Landlord's regular business hours and shall be limited to either or both of the two immediately preceding calendar years. Tenant
shall be entitled to obtain an audit by an independent certified public accountant or such representative of Tenant as Tenant shall
otherwise select (provided that such representative shall not, in any event, be compensated on a recovery or contingency fee basis
and shall otherwise be reasonably acceptable to Landlord) to determine the accuracy of Landlord's certification of the amount of
Additional Rent charged to Tenant. Tenant shall bear the total cost of any such audit, including reimbursing Landlord for any out-of-pocket
expenses (e.g., photocopying charges, accountant's fees, etc.) reasonably incurred by Landlord in connection with Tenant's audit.
Notwithstanding the preceding to the contrary, if the audit reveals that Tenant's Proportionate Share of Expenses for such calendar
year was overstated by more than 5%: (i) Landlord shall reimburse Tenant for the reasonable costs incurred by Tenant in conducting
the audit (to be reimbursed to Tenant within 30 days following Landlord's receipt of written demand from Tenant, along with reasonable
supporting documentation); and (ii) Tenant shall have no obligation to reimburse Landlord for its out-of-pocket expenses incurred
in connection with such audit. Any deficiency/overpayment determined by the audit shall be paid by/refunded to Tenant within 30
days after acceptance of the results of the audit by Landlord, which shall not be unreasonably withheld or delayed. In no event
shall Tenant have any right to examine Landlord's books and records while Tenant is in default under the terms of this Lease. As
an express condition of Tenant's rights under this Section, Tenant shall and shall use commercially reasonable efforts to ensure
that its auditors shall keep the existence of the audit, any and all financial information obtained from the audit, and the results
of its audit confidential except to the extent necessary to resolve any dispute between Landlord and Tenant relating to the Expenses
or to satisfy public reporting requirements. A breach of this confidentiality obligation shall automatically be an Event of Default
(i.e., Tenant shall have no right to notice of, or right to cure, that breach) and Tenant shall forfeit all rights to conduct any
further audits pursuant to this Section.

 

    	 	7

     

    

 

5.4. Dispute in Additional Rent. If Tenant disputes
any billing for Additional Rent, at any time prior to the date that is more than 18 months after Tenant's receipt of the Statement
in dispute, Tenant may serve written notice on Landlord demanding arbitration of the dispute. As an express condition precedent
to invoking arbitration, Tenant must have paid the entire amount of Additional Rent set out in the Statement (including the amount
disputed) to Landlord, subject to any later adjustment as may be ordered in the arbitration decision. Failure to timely pay the
Additional Rent shall render any demand for arbitration absolutely void and shall constitute an Event of Default. If there is no
timely demand for arbitration and/or payment as contemplated in this Section, the applicable Statement rendered by Landlord shall
be deemed correct in all respects and shall no longer be open to challenge by Tenant.

 

5.5. Stamp, Use, Sales Tax Adjustment. Should any governmental
authority having jurisdiction over the Premises declare or otherwise assess against Landlord any tax on Tenant's rents, lease,
or leasehold whether designated as a stamp tax, sales tax, ad valorem tax, use tax or otherwise (other than income taxes), then
all taxes so charged shall be Tenant's obligation and shall be paid by Tenant directly to the taxing authority or shall be paid
to Landlord in reimbursement.

 

5.6. Net/Net/Net Lease. Except as specifically provided
to the contrary in this Lease, it is the intention of the parties that the rentals shall be net to Landlord and that all
costs, expenses, and obligations (including taxes, insurance, operating expenses, and utilities, but excluding any costs and expenses
specifically excluded pursuant to Section 5.3.1) relating to the Tenant’s occupancy of the Premises shall be
borne by Tenant. Tenant shall pay and otherwise indemnify Landlord against any and all such costs, expenses, and obligations not
otherwise chargeable to Landlord under the terms of this Lease. If Landlord shall make any expenditure for which Tenant is responsible,
or which Tenant should make, then the amount of that expenditure shall be added to and shall be due as Additional Rent with the
next installment of Base Rent.

 

5.7. Late Charges. Tenant's failure to timely pay Rent
may cause Landlord to incur unanticipated costs. If any payment of Rent is not received within 10 days of its due date, Tenant
shall pay Landlord a late charge equal to 2.5% of the overdue amount. Tenant acknowledges that such late charge represents a fair
and reasonable estimate of the costs Landlord will incur by reason of such late payment. The payment of late charges shall not
excuse or cure any default by Tenant under this Lease. Interest shall not be payable on late charges to be paid by Tenant under
this Lease. Notwithstanding the preceding, so long as the Rent is paid by Tenant within 10 days of its receipt of written notice
of such delinquency, Tenant shall not be responsible for late charges for such delinquency the first time it occurs in any 12-month
period; provided that this waiver of late charges shall not, in any event, apply after the third delinquency during the Term.

 

6. SECURITY DEPOSIT/FINANCIALS.

 

6.1. Security Deposit. Within six business days after
the Execution Date, Tenant shall deposit the Security Deposit Amount with Landlord as security for Tenant's full and faithful performance
of all of its obligations under this Lease (the "Security Deposit"). Tenant shall thereafter continuously
maintain the Security Deposit in place until that date which is 100 days after: (i) the Expiration Date; or (ii) date of earlier
termination of this Lease. Tenant, at its option, may post the Security Deposit in the form of cash or an irrevocable, standby
letter of credit in favor of Landlord (the "Letter of Credit"). If Tenant elects to use a Letter of Credit:
(a) Landlord shall have no obligation to accept a Letter of Credit unless it complies, in all respects, with the provisions of
Exhibit G attached, which shall be determined in Landlord's sole discretion; and (b) if accepted by Landlord, the
Security Deposit shall remain in the form of the Letter of Credit unless and until the parties mutually agree, in writing, otherwise.
Landlord is authorized to charge any damages it may sustain as the result of any default by Tenant against the Security Deposit;
provided that in no event shall Landlord be entitled to draw more than the Maximum Draw Amount (as defined in Exhibit G)
in effect at that time. Unless there is a bona fide dispute between Landlord and Tenant related to use of the Security Deposit
(in which case the process contemplated under Section 17.3 will be followed), if any portion of the Security Deposit
is in the form of cash and, i, prior to the termination of this Lease Landlord uses all or part of that cash portion the Security
Deposit, in whole or in part, , Tenant shall immediately restore the cash amount so used by Landlord. At the Expiration Date, an
earlier termination of this Lease, and/or whenever Tenant is required to restore amounts of the Security Deposit, Tenant shall
be entitled to an accounting of all disbursements and applications of the Security Deposit made by Landlord as of that date. Within
90 days after the expiration or earlier termination of this Lease, any unused portion of the Security Deposit shall be returned
to Tenant, but only after an inspection of the Premises has been made by Landlord after vacation by Tenant, provided such inspection
occurs with 30 days of vacation and subject to application of the Security Deposit as allowed under this Lease or otherwise by
law. Notwithstanding the fact that this Lease may have expired or been terminated, Landlord's right to use the Security Deposit
as otherwise provided in this Section shall continue in full force and effect with respect to any amount received by Landlord in
payment of Tenant's obligations under this Lease which Lender may be required to repay under any bankruptcy or insolvency laws.
Any cash portion of the Security Deposit may not be commingled with other Landlord's funds. Tenant shall not be credited with or
entitled to any interest from Landlord on its Security Deposit.

 

    	 	8

     

    

 

6.2. Financials. Upon Landlord's request (which, except
in connection with a potential refinancing or sale of the Building, will not be more frequent than once in any 12-month period),
Tenant shall provide Landlord with a copy of Tenant's most recent financial statements (to include, at least, a current balance
sheet and statements of profit and loss and cash flow, all prepared in accordance with GAAP, consistently applied) which shall
be certified by an officer/manager of Tenant and such other financial information concerning Tenant as reasonably requested by
Landlord. Landlord agrees to hold that financial information in confidence and to use the same degree of care in protecting the
confidentiality of that information as it uses in protecting its own confidential information, which shall not be less than a reasonable
degree of care. For as long as Tenant is a publically traded company, it shall not be required to provide the financial information
otherwise required under this Section.

 

7. IMPROVEMENTS. 

 

7.1. Landlord Improvements.  Landlord, at its sole
cost and expense, has designed and constructed the Building as reflected in the Landlord Improvements. As of the date of delivery
of the Premises to the Tenant, Landlord represents that the Building Improvements have been substantially completed in substantial
accordance with that Exhibit and otherwise in a good and workmanlike manner and in substantial compliance with all applicable building,
fire, health, and sanitary codes and regulations and other applicable laws.

 

7.2. Tenant Upfit.  Promptly after the Tenant Upfit
Budget and Bidder are mutually approved, Landlord, at Tenant's sole cost and expense, shall commence and diligently pursue completion
of the Tenant Upfit to be constructed by it on the Premises. All Tenant Upfit shall be constructed in substantial accord with the
Approved Plans & Specs (as defined in Exhibit D), in a good and workmanlike manner, and otherwise in substantial
compliance with all applicable building, fire, health, and sanitary codes and regulations, and shall be performed by a licensed
general contractor selected by Landlord and reasonably acceptable to Tenant. Unless otherwise noted in writing in the Approved
Plans & Specs or in the applicable Change Order, the Tenant Upfit shall remain and be surrendered with the Premises on expiration
of this Lease. If the Approved Plans & Specs or the Change Order provides that certain improvements are not to be surrendered,
Tenant, at its sole cost, shall, upon termination of this Lease, remove those Tenant Upfit which are not to remain and repair all
damage to the Premises or the Building caused by their removal. This removal/repair obligation shall survive a termination of this
Lease. Notwithstanding the foregoing, Tenant shall be permitted to remove that personal property as described in Section
8.1.

 

7.3. Tenant Upfit Allowance. Notwithstanding Section
7.2 to the contrary, Landlord shall contribute the Tenant Upfit Allowance towards the costs and expenses incurred in designing
and/or constructing the Tenant Upfit (the "Upfit Costs"). The Tenant Upfit Allowance shall be paid by Landlord
directly to the general contractor and others based on invoices submitted. Tenant shall be responsible for any and all Upfit Costs
in excess of the Tenant Upfit Allowance (the "Excess Upfit Costs"). Tenant shall, on a monthly basis as
contractor invoices become due, pay to Landlord a proportional amount (based upon the ratio of the estimated total Excess Upfit
Costs to the estimated total Upfit Costs as set out in the Approved Construction Budget) of the estimated Excess Upfit Costs (each
an "Upfit Payment"). Each Upfit Payment shall be made within 10 days of Landlord's written request for
such. Landlord shall use the Upfit Payments in funding the Upfit Costs and shall be entitled to disburse the Upfit Payments to
the general contractor and others based on invoices submitted. If Tenant fails to timely pay an Upfit Payment, Landlord may, among
other legal remedies available to it, suspend construction of the Tenant Upfit for as long as that Upfit Payment remains unpaid.
Each day the construction is suspended for this reason shall be considered a day of Tenant Delay. Any Upfit Costs remaining after
all of the Tenant Upfit Allowance has been disbursed by Landlord shall be paid by Tenant to Landlord as each subsequent contractor
invoice for the Tenant Upfit become due. So long as Tenant timely pays all Upfit Payments, Landlord shall bear the liability of
payment of all invoices and charges related to the Upfit Costs and any steps necessary to release liens or obtain final lien waivers.
The Tenant Upfit Allowance is being given by Landlord on the condition that Tenant fulfills all of its obligations under the Lease
for the entire original Term. Upon a termination of this Lease due to an Event of Default occurring prior to the expiration of
the entire original Term, the then unamortized portion of the Tenant Upfit Allowance (the "UTUA") shall
be deemed forfeited by Tenant and recoverable by Landlord from Tenant. The amount of the UTUA shall be calculated by multiplying:
(i) the total Tenant Upfit Allowance funded by Landlord; by (ii) a fraction, the numerator being the number of months remaining
in the original Term as of the date of the Event of Default and the denominator being 123. This right shall be in addition to other
rights and remedies available to Landlord for an Event of Default; but, in no event, shall it entitle Landlord to a "double
recovery"; i.e., recovery of all Rent due for the entire original Term and recovery of the UTUA.

 

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7.4. Tenant Inspection. Prior to the delivery of a
Phase to Tenant, Landlord and Tenant shall conduct a walk-through of that Phase for the purpose of assuring that all construction
is according to the Approved Plans & Specs, that all utilities are functional, and that that Phase is in good condition. Any
deficiencies observed in the walk-through or identified, in writing, and delivered to Landlord within 90 days after Tenant takes
occupancy of that Phase, shall be noted in writing, signed by both parties (the "Punch List"). (For
avoidance of doubt, a matter that would otherwise require a Change Order cannot qualify as a Punch List item.) The deficiencies
noted in the Punch List shall be cured by Landlord within 30 days of the walk-through or later notification provided to Landlord;
provided that if a listed item cannot be reasonably cured within that 30-day period, Landlord shall: (i) provide a reasonable written
schedule for completion of those items; and (ii) not be in default so long as it is promptly and diligently pursuing a correction
of that item. The completion of the Punch List shall not delay the Commencement Date or the Rent Commencement Date, as applicable,
if the Tenant Upfit for the applicable Phase has otherwise been Substantially Completed. Landlord shall give Tenant reasonable
advance written notice of the scheduled walk-through for purposes of inspecting the completed Tenant Upfit and preparing the Punch
List. Tenant's failure to timely meet with Landlord for preparation of the Punch List shall be deemed acceptance of the applicable
Phase as constructed.

 

7.5. Construction Warranty. Landlord represents
that as of completion of each Phase: (i) the applicable Tenant Upfit will be constructed in accordance with the Approved Plans
& Specs, in all material respects; (ii) the plumbing, electrical, HVAC, fire suppression, and other basic building systems
serving that Phase shall be in good working order and condition; and (iii) to the best of its knowledge, the Building will comply
with all applicable local, state, and federal legal requirements. If there is a breach of this warranty which is communicated to
Landlord within one year following the date of Substantial Completion for a particular Phase, Landlord shall use commercially reasonable
efforts to enforce any warranty given by Landlord's Contractor for the Tenant Upfit for that Phase, unless Tenant has previously
given Landlord (whether orally or in writing) an acceptance of such condition. Landlord shall otherwise make available to Tenant
any warranties Landlord has received with respect to the repairs to be performed by Tenant under the terms of this Lease.

 

8. ALTERATIONS, ADDITIONS, AND IMPROVEMENTS.

 

8.1. Restrictions. Tenant shall not make any Alterations
without Landlord's reasonable prior written consent. The plans and specifications for any approved Alterations shall be subject
to Landlord's reasonable prior written approval and once approved, shall not be materially changed without Landlord's reasonable
prior written consent. Tenant shall provide Landlord with a copy of the plans and specifications and estimated construction costs
for the Alterations prior to commencing construction. All Alterations shall be: (i) made promptly, in a good and workmanlike manner,
and otherwise in substantial compliance with all applicable building, fire, health, and sanitary codes and regulations; (ii) made
so as not to unreasonably disturb or inconvenience other tenants in the Building; and (iii) shall be paid for by Tenant allowing
no liens to attach either to the Premises or to Tenant's leasehold interest. Landlord shall have the right to require Tenant to
provide such assurances as Landlord shall reasonably require (e.g., bonds, escrows, etc.) to protect Landlord against unpaid work
and to require that any work be performed only by duly licensed contractors and subcontractors reasonably approved by Landlord.
Upon a termination of this Lease and Landlord's written request, Tenant shall provide Landlord with copies of all unexpired construction
warranties related to the Alterations, all of which shall be deemed assigned to Landlord; provided that such assignment shall be
deemed "as is", without representation or warranty by Tenant of any kind (including any warranty of assignability).
Unless otherwise noted in Landlord's written approval of the Alteration, each Alteration shall remain and be surrendered with the
Premises on termination of this Lease. For all Alterations made by Tenant pursuant to Section 8.2 not requiring Landlord's
approval and all Alterations where Landlord's written approval expressly provides that the Alteration is to be removed by Tenant
at the end of the Term, Tenant, at its sole cost, shall remove such Alterations and shall repair all damage to the Premises and/or
the Building caused by that removal at the expiration or earlier
termination of the Term. In no event, however, shall Tenant remove (or be required to remove) any of the following materials or
equipment (which shall be deemed Landlord's property) without Landlord's prior written consent: any power wiring or power panels;
casework; fume hood; communications cabling; lighting or lighting fixtures; wall coverings; drapes, blinds or other window coverings;
carpets or other floor coverings; heaters, air conditioners, or any other heating or air conditioning equipment; or other similar
standard building operating equipment and decorations. Notwithstanding the foregoing, Tenant shall be permitted to remove and repair
any fixtures, including installed fixtures, which include its intellectual property or trade secrets, and any of the personal property
listed on Exhibit N. This removal/repair obligation shall survive a termination of this Lease. Notwithstanding anything
in this Lease to the contrary, Tenant shall be responsible for any ad valorem taxes or increase therein resulting from Alterations
made by or at the direction of Tenant.

 

    	 	10

     

    

 

8.2. Exception. Notwithstanding anything in Section
8.1 to the contrary, Tenant shall have the right to make Alterations to the interior of the Premises without obtaining
Landlord's prior written consent if such Alterations: (i) do not exceed $25,000.00 in cost in any one instance or $200,000.00,
in the aggregate, over the full Term; (ii) are non-structural in nature, are not visible from the exterior of the Building, and
do not affect any of the Building's systems; and (iii) do not require a governmental permit. At least 10 days before the construction,
Tenant must provide Landlord with prior written notice of its intention to make such Alterations (stating in reasonable detail
the nature, extent, and estimated cost of such Alterations), together with a copy of the plans and specifications for the Alterations.
All of the other provisions of Section 8.1 shall apply to Alterations made under this Section.

 

9. SERVICES/PARKING/REPAIRS.

 

9.1. Utilities/Janitorial/Trash Removal.  Utility services
for the Premises will be provided as follows:

 

	Utility Service for Premises	Provider/Cost Allocation
	Data and Communication	Tenant's Provider/100% to Tenant
	Water & Sewer	City of Raleigh/Tenant's Proportionate Share (Section 5.3)
	Electrical	NCSU/Tenant's Allocable Costs (Exhibit M)
	Chilled Water for HVAC	NCSU/Tenant's Allocable Costs (Exhibit M)
	Natural Gas	PSNC/ Tenant's Allocable Costs (Exhibit M)
	Janitorial and Trash Removal	Tenant's Provider/100% to Tenant
	Other	Tenant's Provider/100% to Tenant

 

Landlord shall contract with the City of Raleigh, NCSU, and PSNC for the utility services
to be provided by those entities. Tenant shall be solely responsible for contracting with each utility service provider (each a
"Tenant's Provider") for each of those services indicated to be provided by a "Tenant's Provider".
Each Tenant's Provider shall nevertheless shall be subject to Landlord's prior reasonable approval. Tenant, at its sole expense,
shall also supply and replace all LED bulbs required for its operations at the Premises during the Term. Tenant shall promptly
report any interruption of its utility service to Landlord and to the applicable utility service provider. If such an interruption
is: (i) as to a Tenant's Provider; or (ii) as to any other utility service provider, not caused by Landlord's gross negligence
or willful misconduct, there shall be no abatement or reduction of Rent for such interruption, nor shall such interruption constitute
either a constructive or partial eviction.

 

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9.2. Access/Parking. Landlord shall provide Tenant
with 24 hours, 7 days a week, 52 weeks a year access to the Premises; provided, however, that when the Building is locked, Tenant's
employees may access the Building by using a card access system. The Common Areas shall include not less than 293 parking spaces.
Tenant shall have non-exclusive access to the sidewalks, entrances, parking lot(s), and driveways serving the Building. Unless
specifically provided below, Tenant shall have no designated parking spaces and shall observe any restricted parking areas designated
by Landlord for specific tenants, customers, handicapped individuals, etc. Landlord shall, at no additional charge, provide Tenant
with the Parking Spaces; provided that Tenant shall be responsible for all permit fees charged by NCSU. Tenant shall not permit
its employees to use those restricted parking areas or the driveways or entrances within the Building or, without NCSU's prior
written consent, the adjacent streets, for the parking or storage of any automobiles, trucks, or vehicles owned or used by them.
As reasonably deemed necessary by it, Landlord shall have the authority to further assign or otherwise restrict parking areas for
Tenant and the other tenants of the Building and their respective employees, provided that all parking restrictions shall apply
equally to all tenants of the Building. Tenant's use of the parking facilities shall be at Tenant's sole risk, and Tenant acknowledges
that Landlord shall have no liability whatsoever for damage to the vehicles of Tenant, its employees, and/or its visitors, or for
other personal injury or property damage or loss relating to or connected with the Tenant's, its employees', and/or its invitees'
use of the parking facilities serving the Premises.

 

9.3. Maintenance & Repairs.

 

9.3.1. Landlord Obligations. Landlord shall
maintain, repair, and replace: (a) the structural integrity of the Building (including the foundation, the exterior walls (excluding
exterior glass, windows, and the interior surfaces of those walls), the supporting framework, the demising walls (exclusive of
any wall coverings), roof and roof membrane); (b) plumbing, electrical, and mechanical systems and utility lines serving the Common
Areas and the Building, but not including any portion of such systems or lines that exclusively serves any tenant space within
the Building; (c) the Common Areas; (d) any defects relating to the initial construction of the Building (including any failure
to be in full compliance with applicable building, fire, health, and sanitary codes and regulations in existence as of the Commencement
Date if such compliance is later required by the applicable governmental authority for any reason); and (e) any damages resulting
from its or its employees', agents', or contractors' negligence or willful misconduct. Repairs required of Landlord shall be made
within a reasonable time (depending on the nature of the repair needed) after Landlord receives notice from Tenant, or has actual
knowledge, of the need for the repair. Except where the need for the maintenance or repair is attributable to the Landlord Parties'
negligent or willful acts, the maintenance/repair costs incurred by Landlord shall be included in “Expenses”.

 

9.3.2. Tenant Obligations. Subject to the obligations
of, and except as assigned to, Landlord above, Tenant, at its own expense, shall maintain and repair the interior, non-structural
portions of the Premises (including the repair and replacement of the mechanical, plumbing, electrical systems, those portions
of all utility lines serving the Premises running from the Premises to the point where the lines are connected to the common system
serving the Building, interior walls, floors, ceilings, security systems, canopy sign, all exterior glass, and the monitoring systems)
and otherwise make all repairs relating to the Premises not assigned to Landlord. Tenant is obligated to maintain the Premises
in good condition and repair. All repairs to be made by Tenant shall be made promptly, in a workmanlike manner, paid for by Tenant
allowing no undisputed liens to attach either to the Premises or to Tenant's leasehold interest, and so as not to unreasonably
disturb or inconvenience other tenants in the Building. Landlord shall have the right to require Tenant to provide such assurances
as Landlord shall reasonably require (e.g., bonds, escrows, etc.) to protect Landlord against unpaid work and to require that any
work be performed only by duly licensed contractors and subcontractors reasonably approved by Landlord. Notwithstanding anything
to the contrary in Section 9.3.1, Tenant shall reimburse Landlord for all expenses incurred by Landlord (over and
above those amounts reimbursed by insurance carried by Landlord), along with a 15% overhead fee, in making repairs arising out
of Tenant's or its employees', agents', invitees, or contractors' negligence or willful misconduct or Tenant's failure to make
those repairs assigned to Tenant under this Section after notice and a reasonable opportunity to cure. Landlord shall make available
to Tenant any warranties Landlord has received which are applicable to the repairs to be performed by Tenant. Continuously throughout
the Term, Tenant shall maintain, at its expense, a maintenance contract covering the HVAC system located in or serving exclusively
the Premises with a service contractor reasonably acceptable to Landlord. This maintenance contract shall provide for periodic
inspections, periodic maintenance reports, routine maintenance (including timely changing of all filters at recommended intervals),
adjustment, and inspection of air handling mechanisms and control equipment, and performance of necessary lubrication, testing,
and other normal maintenance procedures. At least every calendar quarter during the Term, Tenant shall provide copies of the HVAC
System maintenance reports to Landlord.

 

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9.4. Security. Tenant acknowledges that NCSU provides
security for the Campus and Landlord shall have no obligation to provide security services for the Building. In addition to the
security provided by NCSU. The Tenant Upfit shall include exclusive, secured access to the third floor of the Building, card-key
security readers at all entrances to the Premises, and other security measures shown on the Approved Plans & Specs. Landlord
shall cause the Landlord Improvements to include card-key security readers at all entrances to the Building and security cameras
throughout the Common Areas. Notwithstanding anything in this Lease to the contrary, Landlord shall not be liable for any loss
or damages suffered by Tenant or anyone else for failing to supply such services or manned traffic control, no matter how caused.
In no event shall Tenant be relieved of its duty to maintain security within the Premises.

 

10. TAXES AND ASSESSMENTS. Landlord shall list the Building
for ad valorem tax purposes and shall pay those taxes and applicable assessments of whatever kind or nature assessed against the
Building, all of which shall be included in "Expenses". Tenant shall pay all taxes and assessments assessed by
a third party taxing authority against the Tenant Upfit (to the extent of the Excess Upfit Costs that do not become part of the
realty) and all of Tenant's personal property located on the Premises, whether affixed or not, and all other taxes, fees and assessments
imposed for its use of the Premises.

 

11. SIGNS. Landlord shall include Tenant's name
and suite number on: (i) the Building directory(ies) located inside the Building; (ii) a Building-standard suite sign to be located
at the entrance to the Premises; and (iii) at Tenant’s expense, monument signage with ordering of tenants on a "first
come, first served" basis. For Tenant's initial listing, the cost of such directory(ies) and suite signage shall be at
Landlord's sole expense. Any subsequent changes to directory(ies) and suite signage requested by Tenant shall be paid for by Tenant
within 30 days of receipt of Landlord's invoice for actual and reasonable costs relating thereto. Except as contemplated above,
Tenant shall not permit, erect, install, or display on its any exterior door, wall, or window of the Premises or anywhere else
in or on the Building any sign, lettering, placard, decoration, or advertising material of any kind whatsoever, without Landlord's
reasonable prior written consent. All exterior decor and exposed sides of drapes, blinds, shutters, and other window treatments
must receive Landlord's prior written reasonable approval.

 

12. INSURANCE/INDEMNIFICATION.

 

12.1. Property Insurance. Landlord shall carry full
replacement cost, all-risk property damage and hazard/casualty insurance with extended coverage insuring against loss or damage
to the Building and/or other improvements with customary deductibles and companies as Landlord in its discretion chooses. The cost
of this insurance maintained by Landlord shall be included in "Expenses". The policy shall show Landlord as the named
insured and Landlord's Lender as an additional insured. Tenant shall maintain and care for its personal property on or at the Premises
and all Alterations, if any, and insure the same to such extent as it deems appropriate. Tenant shall carry full replacement cost,
all-risk property damage and hazard/casualty insurance with extended coverage insuring against loss or damage to Tenant's Alterations,
improvements, furnishings, fixtures, equipment, and other personal property situated in or about the Premises, as well as all exterior
glass included in the Premises.

 

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12.2. Liability Insurance. Tenant shall, at its expense,
maintain in effect a commercial general liability policy with coverages not less than the Tenant Liability Coverage. This policy
shall: (i) be primary and non-contributing; (ii) contain cross-liability endorsements; and (iii) show Landlord and Managing Agent
as additional insureds. Limits in excess of $1,000,000.00 for the commercial general liability policy may be provided by an umbrella/excess
policy. Landlord shall maintain in effect a commercial general liability policy with coverages not less than the Landlord Liability
Coverage. The cost of this insurance shall be included in "Expenses". Limits in excess of $1,000,000.00 may be
provided by an umbrella/excess policy. Landlord shall maintain in effect a commercial general liability policy with coverages not
less than the Landlord Liability Coverage. The cost of this insurance maintained by Landlord shall be included in “Expenses”.
The amount and coverage of such insurance shall not limit a party's liability nor relieve that party of any other obligation under
this Lease.

 

12.3. Worker's Compensation. Tenant shall, at its expense,
maintain Worker's Compensation Insurance coverage sufficient to meet all local, state and federal governmental regulations.

 

12.4. Business Interruption Insurance. Tenant shall,
at its expense, maintain business interruption insurance in an amount equal to the Business Interruption Insurance Coverage. This
insurance shall insure that the Base Rent will be paid to Landlord (unless such Rent is abated or this Lease terminates, as provided
below) if the Premises are destroyed or rendered unusable by a risk insured against by a policy of standard fire and extended coverage
insurance, with vandalism and malicious mischief endorsements

 

12.5. Policies. All required policies of insurance
shall be maintained continuously throughout the Term and provide that they: (i) may not be changed or cancelled without 10 business
days' prior written notice to Landlord; and (ii) shall be underwritten by insurers who have a Best's Financial Strength Rating
of "A-" or better and a Best's Financial Size Category of at least "XII" as set forth in the then most current
issue of "Best Key Rating Guide" (or if the Best's ratings are discontinued, a comparable method of rating insurance
companies), who are licensed to do business in North Carolina, and who are authorized to issue the policies. At either party's
request, a certificate (ACORD Form No. 25 or equivalent) evidencing the required insurance shall be given to the requesting party.
The general liability policies shall be on ISO Form CG 0001 0196 or equivalent "occurrence basis" insurance policy form.
Upon 30 days' advance written notice to Tenant, Landlord may, from time to time, increase any required coverage amounts specified
in this Section based upon inflation, increased liability awards, recommendation of Landlord's professional insurance advisers,
or as needed to meet Landlord's Lender's requirements. If Tenant fails to deliver any policy, certificate, or renewal to Landlord
required under this Lease within the prescribed time period or if any such policy is cancelled or modified during the Term without
Landlord's consent, Landlord may obtain such insurance, in which case Tenant shall reimburse Landlord for the cost of such insurance
within 15 days after receipt of a statement that indicates the cost of such insurance, which statement shall be accompanied by
a copy of the insurance policy obtained by Landlord.

 

12.6. Indemnification. Except where caused by a Landlord
Party's negligence, gross negligence or willful misconduct, Tenant shall indemnify and hold the Landlord Parties harmless from
any liability for injury to or death of any person or damage to any property relating to or arising out of Tenant's or its invitee's,
employee's, agent's, or contractor's use or occupancy of the Premises or Common Areas or breach of its obligations under this Lease.
Landlord shall indemnify and hold the Tenant Parties harmless from any liability for injury to or death of any person or damage
to any property relating to or arising out of the Landlord Party's negligence, gross negligence or willful misconduct. If the party
to be indemnified is made a party to any litigation commenced by or against it for which it is to be indemnified, then the indemnifying
party shall protect and hold harmless and pay all court costs, penalties, charges, damages, expenses, and reasonable attorneys'
fees incurred or paid by the party to be indemnified. All acts attributable to a party shall extend to that party's members, officers,
directors, employees, agents, shareholders, parent, and affiliates provided that the other tenants in the Building shall not be
included in these groups. These indemnification obligations shall survive a termination of this Lease.

 

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12.6. Waiver of Subrogation. Notwithstanding the language
of Section 12.5 to the contrary or that the loss or damage may be due to or result from the negligent or willful
act of a party or its employees or agents, Landlord and Tenant, for themselves and their respective insurers, release each other
from any and all claims, demands, actions and causes of action that each may have or claim to have against the other for loss or
damage to persons or property, both real and personal, caused by or resulting from casualties required to be insured against by
the terms of this Lease or otherwise insured against by the party suffering the loss or damage. For the purpose of the foregoing
waiver/release, the amount of any deductible applicable to any loss or damage shall be deemed covered by, and recovered by the
insured under, the insurance policy to which such deductible relates. All policies of insurance required by this Lease shall contain
a provision whereby the insurer waives all rights of subrogation against either Tenant or Landlord, as appropriate. If insurance
policies with waiver of subrogation provisions shall be obtainable only at a premium, the party seeking the policy shall pay that
additional premium. Except to the extent a party's insurance pays (or would have paid if the insurance coverage required by this
Lease were in effect) a claim that otherwise would be subject to indemnification by the other party, this release is not intended
to nor shall it release such other party from its indemnification obligations as set out in this Lease. These obligations shall
survive a termination of this Lease.

 

13. DESTRUCTION/CONDEMNATION.

 

13.1. Destruction of Premises.

 

(A) Substantial Destruction. If the Premises are totally
or substantially (more than 70%) destroyed by fire or other casualty, either Landlord or Tenant may terminate this Lease by giving
written notice of termination not later than 60 days after the date of the destruction. In that event and provided Tenant timely
vacates the Premises, Base Rent and Additional Rent paid for the period beyond the date of destruction shall be refunded to Tenant
and neither party shall have any further obligations under this Lease except for those obligations which are expressly provided
to survive a termination.

 

(B) Partial Destruction. If there is not total or substantial
destruction of the Premises as described above, yet: (i) Landlord, in its sole judgment, concludes that restoration of the damage
cannot be completed within 270 days; or (ii) less than six months of the Term remains and the repairs are reasonably estimated
to require more than 30 days to repair; or, (iii) insurance proceeds (along with funds Landlord, in its discretion, decides to
provide) in an amount sufficient to restore the Premises are not made available to Landlord (provided, that Landlord shall use
commercially reasonable efforts to obtain the proceeds to which it is entitled under its applicable insurance policy); either Landlord
or Tenant may, at its option, terminate this Lease by giving written notice of termination to the other party not later than 30
days after the date Landlord provides Tenant with the information described below. In that event and provided Tenant timely vacates
the Premises, Base Rent and Additional Rent paid for the period beyond the date of destruction shall be refunded to Tenant and
neither party shall have any further obligations under this Lease except for those obligations which are expressly provided to
survive a termination. Within 30 days after the casualty, Landlord shall furnish Tenant with Landlord's estimate of the time required
to complete repairs and whether or not sufficient funds are available to pay for the required repairs.

 

(C) Repair/Restoration. If this Lease is not terminated
pursuant to Subparagraphs (A) or (B), Landlord, at its expense, shall promptly restore and/or repair the Premises and any other
portions of the Building outside the Premises required for Tenant's use of the Premises; provided that, in no event shall Landlord
be required to restore or repair: (i) Tenant Upfit to the extent of the Excess Upfit Costs or Alterations; (ii) fixtures or improvements
made or owned by Tenant; or (iii) any of Tenant's personal property, all of which shall be Tenant's sole responsibility. If Tenant
is reasonably required to close all or a portion of its operations during the period of repair/restoration, Base Rent and Additional
Rent shall abate on a proportional basis (based upon the square footage of the unusable portion of the Premises) during that period.
In no event shall Landlord have any liability for losses claimed by Tenant resulting, directly or indirectly, from Tenant's inability
to use the Premises.

 

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(D) Tenant's Fault. Notwithstanding the above to the
contrary, if the Premises are damaged due to willful or grossly negligent acts or omissions of Tenant, its employees, agents, contractors,
or invitees, Tenant may not terminate this Lease and there shall be no apportionment or abatement of Rent.

 

(E) Waiver. Tenant acknowledges that the provisions
of this Section shall govern the rights and obligations of the parties in the event of any substantial or total destruction to
the Premises and Tenant waives the protection of any statute, code or judicial decision which grants a tenant any other rights
to terminate a lease in the event of the substantial or total destruction of the Premises.

 

13.2. Condemnation of Premises. If all of the Premises,
or a portion which will make the remainder unusable for the Permitted Use, be taken under the power of eminent domain (or a conveyance
in lieu thereof), then this Lease shall terminate as of the vesting of title in the condemning authority and Base Rent and Additional
Rent obligations shall be adjusted between Landlord and Tenant as of that date. If only a portion of the Premises are taken and
Tenant can reasonably continue use of the remainder, then this Lease will not terminate, but Base Rent and Additional Rent obligations
shall abate in a just and proportionate amount to the loss of use occasioned by the taking. Except as otherwise provided by the
authority granting an award of damages, Tenant shall have no right or claim to any part of any award made to or received by Landlord
for any taking of the Premises and no right or claim for any alleged value of the unexpired portion of this Lease; provided, however,
that Tenant shall not be prevented from making a claim against the condemning party (but not against Landlord) for any moving expenses,
loss of profits, or taking of Tenant's personal property (including its leasehold interest) to which Tenant may be entitled. No
Tenant's claim may, however, diminish Landlord's or Landlord's Lender's award with respect to the Premises. For purposes of this
Section, Landlord and Tenant shall make a good faith determination as to whether or not the Premises are still suitable for the
Permitted Use after a taking. If less than a fee title to all or any portion of the Premises shall be taken or condemned by any
governmental authority for temporary use or occupancy, this Lease shall continue in full force and effect; but with Rent abated
during any period when Tenant's use of the Premises is impaired in proportion to the impairment of such use.

 

14. CARE/RETURN OF PREMISES.

 

14.1. Care of Premises. Tenant shall not permit or
cause any act to be performed upon, in or about the Premises which shall cause or be likely to cause injury to any person or to
the Premises, the Building, the Common Areas, or any adjoining property. Tenant shall at all times keep the Premises in a neat
and orderly condition. Tenant shall take reasonable care of the Premises, fixtures, and appurtenances and suffer no waste or injury
thereto and shall pay for all repairs to the Building or Premises necessitated by the fault of Tenant, its employees, agents, customers,
or guests. Tenant shall comply with all trash storage policies established by Landlord from time to time.

 

14.2. Return of Premises. Upon the termination of this
Lease, Tenant shall return the Premises to Landlord substantially in the same condition as received and shall deliver the certification
required under Exhibit J, which shall also include a certification as to bio-hazard and toxic materials, to Landlord.
Excepted from this obligation are: (i) conditions which are Landlord's responsibility or result from Landlord's or its agent's
or employee's gross negligence (except to the extent covered by insurance maintained by Tenant), a casualty or a condemnation;
(ii) ordinary wear and tear (which Tenant is not otherwise obligated to repair under Section 9.3.2); and, (iii) Landlord-approved
Alterations which Landlord has not required to be removed. Tenant shall be responsible for all damages to the Building or Premises
caused by the removal of their equipment and trade fixtures from the Premises. The obligations in this Section shall survive a
termination of this Lease. Any failure by Tenant to comply with this Section shall be deemed to be a holdover (as described in
Section 15) by Tenant for the period it takes Tenant, or if Tenant fails to do so, Landlord to complete any required
repair/replacement activities needed to return the Premises to the required condition.

 

14.3. Surrender of Premises. No act or thing
done by Landlord or its agents or employees shall be deemed to constitute an acceptance by Landlord of a surrender of the Premises
prior to the Expiration Date unless such intent is specifically acknowledged in writing by Landlord. The delivery of keys to the
Premises to Landlord or its agents or employees shall not constitute a surrender of the Premises or effect a termination of this
Lease, whether or not the keys are thereafter retained by Landlord. Neither a surrender of this Lease by Tenant, whether accepted
by Landlord or not, or a mutual termination of this Lease shall work as a merger; but, at Landlord's option, shall operate either
as an assignment to Landlord of all subleases or subtenancies of the Premises or terminate any or all such sublessees or subtenancies.

 

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15. HOLDING OVER. If Tenant remains in possession after the
expiration of the Term or earlier termination of this Lease without the execution of a new lease or Landlord's written consent,
Tenant shall not acquire any right, title, or interest in the Premises. In that event, Tenant shall occupy the Premises as a tenant-at-will
and shall otherwise be subject to all applicable conditions, provisions and obligations of this Lease; except that all options
and rights of renewal, rights of first refusal, and the like, if any, shall terminate. Notwithstanding the preceding, Landlord
shall have the right to pursue summary ejectment of Tenant as provided by law and to recover from Tenant any and all damages suffered
as a result of that holdover, including any indirect, consequential, or special damages sustained by Landlord relating to any loss
of a prospective tenant for the Premises. During the holding over period, Tenant shall continue to pay Additional Rent as prescribed
in this Lease; but shall pay monthly Base Rent equal to the Holdover Rent Multiple times the Base Rent Installment Amount in effect
as of the last month immediately prior to the expiration/termination.

 

16. ASSIGNMENT.

 

16.1. Tenant Restriction. Tenant shall not
assign this Lease or sublet the Premises, in whole or in part, whether voluntarily or by operation of law, without both: (i) Landlord's
reasonable prior written consent; and (ii) NCSU's approval as described in Section 16.2. It shall not be unreasonable
for Landlord to withhold consent if:

 

(i) the assignee/sublessee is engaged in the commercial
real estate business (including property management or the brokerage, ownership, or development of competitive properties), or
the provision of "executive suites" or any similar arrangement;

 

(ii) the assignee/sublessee's business which is not in
some way connected or associated with NCSU, such that the assignee/sublessee would not be qualified to lease space directly from
NCSU in accordance with NCSU's policies for leasing to tenants in the Campus;

 

(iii) it would cause Landlord to be in default of another
lease in the Building or the Campus;

 

(iv) occupancy by the proposed assignee/sublessee would
violate the terms of this Lease or cause Landlord to be in breach of any restrictive covenant relative to the Building or other
leases, or materially increases the costs of operation for the Building;

 

(v) Landlord's Lender withholds its consent or Landlord's
granting consent would be a breach of the Deed of Trust (as later defined), which Landlord takes commercially reasonable efforts
to resolve and is unable to do so; or

 

(vi) the proposed subtenant or assignee is a person or
entity with whom Landlord or its agent is negotiating and to or from whom Landlord or its agent, within the preceding six months,
has given or received any written or oral proposal regarding leasing space in the Building and the Building has suitable space
available for such proposed subtenant or assignee;

 

If Landlord unreasonably withholds its consent, Tenant's sole and exclusive
remedy is specific performance and under no circumstances will Landlord be liable for damages.

 

Any proposed assignment or sublease shall also be subject to the following
additional limitations: (i) Tenant shall not post any signs advertising the availability of the Premises anywhere in (including
inside the Premises) or on the Building; and (ii) all public advertisements regarding the assignment of this Lease or subletting
all or any portion of the Premises, shall be subject to Landlord's prior written reasonable approval. In no event shall this Lease
be assignable by operation of any law. Any attempted assignment of this Lease or sublease in violation of this Section shall be
void and, notwithstanding anything in this Lease to the contrary, shall immediately be an Event of Default (i.e., Tenant shall
have no right to notice of, or right to cure, that default).

 

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16.2. NCSU Approval. The Campus is a research
and advanced technology campus where university, industry, and government partners interact in multidisciplinary programs directed
toward the solution of contemporary problems. A wide range of business uses are permitted in the Campus, including the following:
research and development, information technology, computer software/hardware, advanced materials, engineering, biotechnology, environmental
sciences, agriculture and life sciences, and business management. In the event of a dispute concerning the qualifications of a
potential subtenant under the preceding sentence, the question will be presented to NCSU's Vice Chancellor for Research, Innovation
and Economic Development for a decision. In addition, a variety of commercial and retail support services may be permitted in the
Campus. In the event of a dispute concerning the qualifications of a potential subtenant under the preceding sentence, the question
will be presented to NCSU's Vice Chancellor for Finance and Administration for a decision. Should Tenant be dissatisfied with a
decision made by either Vice Chancellor regarding either of these categories, Tenant shall have the right to submit the question
to the Chancellor of NCSU, whose decision shall be final. Notwithstanding the foregoing, NCSU agrees that: (i) it will not deny
any sublease or assignment to any applicant for reasons other than failure to meet the criteria generally applicable to other prospective
Campus tenants; and (ii) any sublease or assignment applicant which, at the time of such application, is already a tenant in good
standing in another building in the Campus shall automatically be deemed acceptable to NCSU, provided its proposed use of space
is similar to its use of such other space in the Campus.

 

16.3. Notice. If Tenant proposes to assign
any interest in this Lease or to sublet all or any portion of the Premises, Tenant shall first submit to Landlord a written notice
of its intentions (the "Notice of Intent"). The Notice of Intent shall contain: (i) the name of the proposed
assignee/subtenant; (ii) the terms of the proposed assignment/subletting and a copy of the proposed assignment/sublease agreement;
and, (iii) any other information reasonably requested by Landlord. Landlord shall send the Notice of Intent and any other accompanying
materials to NCSU for their approval; but Tenant shall be solely responsible for obtaining that approval. If Landlord consents
to the proposed assignment/sublease, it shall be an express condition of that consent that: (i) Tenant provide Landlord with a
copy of the executed assignment, sublease, or other applicable document promptly after it is executed; and (ii) no material modification
or assignment of that assignment/sublease shall be permitted without Landlord's reasonable prior written consent. Landlord shall
have 15 business days from receipt of the Notice of Intent to consent to or reject Tenant's sublease or assignment.

 

16.4. Liability. Landlord's consent to one transfer
shall not be deemed a consent to any subsequent transfer. Any assignment or sublease to which Landlord may consent (one consent
not being any basis to contend that Landlord should consent to further assignments or subleases) shall not relieve Tenant of its
Lease obligations. If Tenant's transferee defaults under this Lease, Landlord may proceed directly against Tenant without pursuing
remedies against the transferee. Landlord may consent to subsequent assignments or modifications of this Lease by Tenant's transferee,
without notifying Tenant or obtaining its consent, and such action shall not relieve Tenant from liability under this Lease. Landlord's
acceptance of rent from any person other than Tenant shall not be a waiver of any of Landlord's rights.

 

16.5. Costs. If Tenant shall request
Landlord's consent to an assignment/subletting of this Lease, Tenant shall pay Landlord's reasonable and actual attorneys' fees
incurred in connection with that matter, such fees not to exceed $1,500.00 for each request. (This cap shall increase at the
rate of 3% per annum from the Commencement Date.) In addition, Landlord reserves the right, in its discretion and as a condition
of any assignment permitted under any subsection of this Section, to require the assignee to increase the amount
of the Security Deposit to an amount equal to the then effective monthly Installment Amount of Base Rent.

 

16.6. Excess Consideration. In the event of an assignment
of this Lease or a subletting of the Premises, all of the consideration received by Tenant from that assignment or sublease over
the amount paid as Rent during the comparable period (the "Excess Consideration") shall be paid to Landlord
as Additional Rent on a monthly basis. In the event less than all of the Premises is subleased, a pro rata portion (calculated
on a per square foot basis) of the Rent paid by Tenant shall be used in calculating the Excess Consideration. The reasonable leasing
commissions paid by Tenant, the amortization of the cost of any improvements made to the Premises at Tenant's cost for the assignee/sublessee,
the amortization of the Excess Upfit Costs paid by Tenant, and other reasonable, out-of-pocket costs paid by Tenant to unaffiliated
third parties in connection with the assignment/subletting shall be deducted in calculating the Excess Consideration. Excess Consideration
shall not include the price paid to Tenant by the assignee/subtenant for Tenant's equipment, assets, intangible property, stock,
and/or business as a going concern. Within 10 days of the date the assignee/subtenant begins occupancy in the Premises, Tenant
shall send Landlord a copy of the executed Lease Assignment or Sublease, as applicable, and a detailed statement showing the calculation
of the Excess Consideration, including the total consideration to be paid by the subtenant/assignee over the term of the assignment/subletting
and any costs (to be accompanied by reasonable supporting documentation) to be deducted from that amount as permitted by this Section.
Landlord shall have the right, at any time, but not more than once per calendar year, during business hours and upon no less than
five business days’ prior reasonable notice to Tenant, to audit Tenant's books and records to verify the accuracy of that
statement.

 

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16.7 Affiliated Entities. Tenant may, without Landlord's
prior consent, assign this Lease to an Affiliated Entity (as defined below); provided that the assignment to the Affiliated Entity
shall be permitted only so long as the assignment is made for a good faith business purpose and the assignee remains an Affiliated
Entity. Tenant shall nevertheless give Landlord prompt notice of any such assignment or sublease, which shall include the information
specified in Section 16.3. For purposes of this Lease, an "Affiliated Entity" shall mean a partnership,
corporation, or limited liability company over which the owners of Tenant or Tenant has legal control, the purchaser of substantially
all of Tenant's assets (provided the purchaser assumes the Lease, in writing, in a form reasonably acceptable to Landlord), or
the surviving entity in a merger involving Tenant. An assignment pursuant to this Section shall not release Tenant or any guarantors
from their respective obligations under this Lease. Notwithstanding anything in this Section 16 to the contrary,
every assignment of this Lease or sublease of any portion of the Premises is subject to NCSU's prior written approval.

 

16.8. Landlord Assignment. Landlord may assign this
Lease to Landlord's Lender as collateral and/or to a purchaser of Landlord's interest in the Building without Tenant's prior consent
or approval.

 

17. DEFAULT/REMEDIES.

 

17.1. Tenant Default. The following events (each an
"Event of Default") shall each constitute a material default by Tenant:

 

(a) If Tenant fails to timely pay any sum due Landlord under this
Lease, which failure shall continue for a period of five business days after receipt or deemed receipt of written notice of that
failure by Tenant; or

 

(b) If Tenant fails to timely perform any non-monetary term, condition,
or covenant of this Lease, which failure continues for a period of 30 days after receipt or deemed receipt of written notice of
that failure by Tenant; provided that if the default cannot be reasonably cured within that period, Tenant shall not be in default
so long as it does not either: (i) fail to commence a cure of the failure within that 30-day period or, thereafter, fail to diligently
continue to pursue such cure to completion; or (ii) fail to cure such failure within a reasonable time after the expiration of
that initial 30-day period (in no event to exceed a total of 90 days after Tenant's receipt or deemed receipt of the written notice
of that failure). Notwithstanding the preceding to the contrary, where a specific time period is otherwise provided in this Lease
for Tenant's performance, the failure to perform by Tenant within such time period shall be an Event of Default (i.e., the cure
periods provided above shall be inapplicable); or

 

(c) Except as contemplated by Section 13, if Tenant
shall vacate or abandon the Premises without the payment of Rent; or

 

(d) An Insolvency Proceeding occurs with respect to Tenant and such
is not stayed or vacated within 60 days of entry thereof and provided Tenant does not continue to pay Rent hereunder; or

 

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(e) If Tenant's interest in this Lease or the Premises
is subjected to any attachment, levy, or sale pursuant to any order or decree entered against Tenant in any legal proceeding and
the order or decree shall not be vacated within 30 days of its entry.

 

(f) If any guarantor of this Lease revokes or otherwise terminates,
or purports to revoke or otherwise terminate, any guaranty of all or any portion of Tenant's obligation under this Lease. Unless
otherwise expressly provided, no guaranty of this Lease is revocable;

 

(h) If Landlord, with reasonable cause, on more than two (2) occasions
in any twelve (12) month period, gives notice to Tenant of default under subparagraphs (a) or (b) above, notwithstanding Tenant's
subsequent cure of the noticed defaults within the allowable periods.

 

The notices required by this Section are intended to satisfy any and all notice requirements
imposed by law on Landlord and are not in addition to any such requirement.

 

17.2. Remedies Upon Tenant Default.

 

(A) Upon the occurrence of any Event of Default, Landlord, with or
without terminating this Lease, immediately or at any time thereafter, shall have the right, at its option, to utilize any one
or more of the following remedies:

 

(i) Landlord may make any payment required of Tenant and/or re-enter the Premises
and correct or repair any condition which shall constitute a failure on Tenant's part to keep or perform. Tenant shall reimburse
Landlord for any reasonable expenditures made by Landlord in making the payment and/or corrections or repairs within 15 days after
delivery of a statement to Tenant accompanied by reasonable documentation supporting the demand.

 

(ii) Landlord may demand in writing that Tenant vacate the Premises. Tenant
shall vacate the Premises and remove all its property within 10 business days of Tenant's receipt of the notice, whereupon Landlord
shall have the right to re-enter and take possession of the Premises.

 

(iii) Landlord may re-enter the Premises and remove Tenant and all
of Tenant's property.

 

(iv) After terminating this Lease, Landlord may re-let all or any portion of
the Premises for such time, rent, and other terms and conditions as Landlord, in its sole discretion, may deem advisable. Landlord
may make any alterations or repairs to the Premises which it may deem necessary or proper to facilitate the reletting. Tenant shall
pay all commercially reasonable costs of the reletting applicable to the Term remaining on this Lease, including the commercially
reasonable cost of any alterations or repairs to the Premises. If this Lease shall have not been terminated by Landlord, Tenant
shall continue to pay all charges due from Tenant under this Lease up to and including the date of beginning of payment of rent
by any subsequent tenant of part or all of the Premises, and thereafter, Landlord may accelerate and collect from Tenant the difference,
if any, between the rent to be collected from that subsequent tenant and the Rent reserved in this Lease for the balance of the
Term, after discounting the difference to its present value by a factor equal to Landlord's Lender's then announced prime rate.
In no event shall Tenant be entitled to receive any excess of any rents collected by Landlord over the Rents due from Tenant. In
no event shall Tenant be entitled to receive any excess of any rents collected by Landlord over the Rent due from Tenant.

 

(v) Landlord may terminate this Lease without notice or demand to vacate the
Premises. This Lease shall be deemed to have been terminated by Landlord only upon Landlord's written notice of termination. Upon
termination Landlord shall nevertheless remain entitled to recover from Tenant all sums provided for in subparagraph (iv) above
as if this Lease were not terminated. In no event shall this subparagraph be interpreted to mean that Landlord may accelerate Rent
hereunder without complying with the requirements of subparagraph (iv) above.

 

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(vi) Landlord may exercise any other remedies and recover any other damages
available to it under law or in equity.

 

(B) In the event of any re-entry of the Premises by Landlord pursuant
to any of the provisions of this Lease, Tenant waives all claims for damages which may be caused by that re-entry except those
damages arising from any Landlord Party's gross negligence or willful misconduct which are not otherwise covered by insurance maintained
by Tenant. Tenant shall reimburse Landlord for any and all losses, costs, expenses (including legal expenses and reasonable attorneys'
fees), and damages suffered by Landlord by reason of its re-entry, removal and/or storage of Tenant's property. No re-entry shall
be considered or construed to be a forcible entry.

 

(C) Upon any material breach of this Lease, regardless of whether
that breach is, or becomes, an Event of Default, Landlord shall be reimbursed for any and all actual and commercially reasonable
expenses incurred by Landlord, including legal expenses and reasonable attorneys' fees, in enforcing the terms and provisions of
this Lease.

 

(D) Any of Tenant's personal property remaining at the Premises 10
business days after a repossession of the Premises by Landlord after an Event of Default or after a termination of this Lease shall
be deemed abandoned by Tenant. Tenant shall be liable for any and all storage and/or removal costs incurred by Landlord in storing
and/or removing that abandoned property. In addition, Landlord shall be entitled to sell the abandoned property in order to recover
those storage/removal costs and any other amounts due from Tenant under this Lease. The sale
of the abandoned property may be by private or public sale as contemplated under the North Carolina Uniform Commercial Code or
in any other form provided by law. This right shall be in addition to any statutory lien for rent or similar rights available to
Landlord under law or this Lease.

 

17.3. Landlord's Default. If, after deliver of the
delivery of the Premises to Tenant, Landlord breaches any of its duties or obligations to Tenant and:

 

(a) in the case of a monetary default, the breach continues for five
business days after written notice is received or deemed received by Landlord; or

 

(b) in the case of a non-monetary default, the breach: (i) continues
for 30 days (or such longer period of time as it may reasonably take to cure provided Landlord promptly and diligently pursues
the cure and is not otherwise in default); or (ii) prevents Tenant from being able to conduct its business in the Phase 3 Space
for 12 or more consecutive days, after written notice of the breach is received or deemed received by Landlord, Tenant may take
such action as is reasonably necessary to cure the breach. For avoidance of doubt purposes, except where another remedy is otherwise
expressly provided in this Lease for a Landlord default, the above remedy shall be Tenant's sole and exclusive remedy for a default
by Landlord. In this event, Landlord shall, upon demand (accompanied by reasonable documentation supporting the demand) reimburse
Tenant for expenses reasonably incurred by Tenant in curing Landlord's breach, including legal expenses and reasonable attorneys'
fees. If Landlord shall fail to promptly reimburse Tenant, Tenant may withhold or abate its rental payment due to the extent of
the unreimbursed expenses. In the event of any dispute about Tenant's right to abate or withhold Rent or other sums payable to
Landlord under this Lease, Tenant must deposit the disputed amounts in escrow in an interest-bearing account with Landlord's Lender,
conditioned on resolution of the dispute by a final, non-appealable court order or by mutual written agreement of Landlord and
Tenant. Any interest earned shall be paid to the party entitled to the escrowed funds and any fees of the escrow agent shall be
paid by the party not entitled to the escrowed funds. Regardless of the outcome or resolution of the dispute, no Event of Default
with respect to the subject matter of the dispute shall be deemed to have occurred so long as the disputed amounts are timely deposited
in escrow by Tenant. Notwithstanding the foregoing, if Landlord has not timely cured a default and the costs which Tenant would
reasonably incur to cure Landlord's default exceed a total of $50,000 in each occurrence, as alternative remedies, Tenant, at its
election, may: (i) sue to specifically enforce Landlord's obligation; or (ii) terminate this Lease without any liability by giving
Landlord written notice no less than 30 days' prior to the effective date of such termination; provided, in either event, that
such alternative remedy is exercised by Tenant within 90 days of the date Tenant has given Landlord written notice of Landlord's
default.

 

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17.4. Mitigation. Whenever a party is in default under
this Lease, the non-defaulting party shall use commercially reasonable efforts to mitigate the damages resulting from the default.
The parties acknowledge that the restrictions of the Ground Lease as to the type of tenants permitted to occupy the space in the
Building will impair Landlord's ability to mitigate its damages by re-leasing the Premises.

 

18. SUBORDINATION/ATTORNMENT/ESTOPPEL.

 

18.1. Subordination. Depending on the requirements
of the then Landlord's Lender, this Lease and the rights of Tenant will either be subordinate or superior to each Deed of Trust.
If Tenant requests such, such subordination shall be subject to the terms of a written subordination, non-disturbance, and attornment
agreement (an "SNDA") between Landlord's Lender and Tenant (and Landlord if requested by Landlord's Lender).
Should Landlord's Lender request an SNDA, so long as the language and provisions comport with the provisions of this Lease and
otherwise are customary for commercial real estate leases of this type, Tenant will execute an SNDA making this Lease superior
or subordinate, as the case may be. Should Tenant fail to timely deliver the SNDA within 15 days of Landlord's Lender's request,
then:

 

(a) Landlord shall be entitled to sign document in the name of Tenant
and each guarantor;

 

(b) such failure shall be deemed an Event of Default without any
further notice to Tenant; and/or

 

(c) Tenant shall pay to Landlord, as Additional Rent, $100.00 per
day for each day past that 15-day period Tenant delays in delivering the SNDA;

 

provided that Landlord may not seek the remedies set forth in this subparagraph for as
long as the delay is attributable to reasonable negotiations between the parties relating to the form or content of the SNDA.

 

Each SNDA shall: (i) be in writing; (ii) include language to the effect that, provided
Tenant is not in default under this Lease beyond applicable notice and cure periods, Tenant's rights under this Lease shall not
be disturbed or affected by any default by Landlord under the Deed of Trust; and (iii) otherwise include provisions customary for
SNDAs for commercial real estate leases of this type. Upon Tenant's written request, Landlord shall use commercially reasonable
efforts to cause the then current Landlord's Lender to enter into an SNDA in the form described in this Section.

 

18.2. Attornment. Tenant and any guarantor of this
Lease shall be bound to a Successor under all of the terms of this Lease for the balance of the Term, with the same force and effect
as if the Successor were Landlord under this Lease. Tenant and any guarantor of this Lease is deemed to attorn to the Successor
as its landlord (but only on the express condition that Tenant's rights under this Lease shall not be disturbed or affected so
long as Tenant is not in default beyond any applicable notice and cure periods under the terms of this Lease) and no further documents
shall be required to effectuate the attornment. Provided Successor becomes legally bound to Tenant in respect of all of Landlord's
duties and obligations accruing under this Lease on and after Successor acquires title, Landlord shall have no further liability
under this Lease for duties or obligations thereafter accruing under this Lease and Tenant shall look solely to the Successor for
any subsequent performance due by Landlord. Each written attornment agreement of Tenant shall: (i) include language to the effect
that, provided Tenant is not in default under this Lease beyond applicable notice and cure periods, Tenant's rights under this
Lease shall not be disturbed or affected by any default by Landlord under the Deed of Trust; and (iii) otherwise include provisions
customary for attornment agreements for commercial real estate leases of this type.

 

18.3. Estoppel Certificate. Within 15 days after Landlord's
or Landlord's Lender's written request, Tenant (and, if applicable, each Guarantor) shall execute a tenant estoppel certificate
(a "TEC") setting forth the following facts with respect to this Lease: (i) its date of occupancy; (ii)
the Term; (iii) the amount of periodic Rent then due and the date to which Rent is paid; (iv) whether or not it has any defense
or offsets to the enforcement of this Lease; (v) its knowledge of any default or breach by Landlord under this Lease; and (vi)
whether or not this Lease is in full force and effect, inclusive of all modifications and/or amendments, copies of which Tenant
shall attach to the TEC. Tenant acknowledges that Landlord and any prospective purchaser or lender may rely on the TEC given by
Tenant and each Guarantor. Should Tenant fail to deliver the TEC, within the 15-day period specified above:

 

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(a) Landlord, and any prospective purchaser or lender, may conclusively
presume and rely upon the following facts: (i) that the terms and provisions of this Lease have not been changed except as otherwise
represented by Landlord; (ii) that this Lease has not been cancelled or terminated except as otherwise represented by Landlord;
(iii) that not more than one month's Base Rent or other charges have been paid in advance; and (iv) that Landlord is not in default
under this Lease. Tenant shall be estopped from denying the truth of such facts; and/or

 

(b) Tenant shall pay to Landlord, as Additional Rent, $100.00 per
day for each day past that 15-day period Tenant delays in delivering the TEC; provided that Tenant shall not be required to pay
such charge if the delay is attributable to reasonable negotiations between the parties relating to the form or content of the
TEC.

 

18.4. Landlord Lender's Rights. If Tenant is notified
of Landlord's assignment of this Lease as security for a Deed of Trust and of the name and address of Landlord's Lender, Tenant
shall not thereafter terminate or cancel this Lease for any default by Landlord without first giving written notice of its intention
to do so to Landlord's Lender (the notice to describe in reasonable detail the nature and extent of the default) and affording
Landlord's Lender the same opportunity (i.e., period of time) to cure the default as given Landlord under the terms of this Lease.
Tenant waives the protection of any statute or rule of law which gives or purports to give Tenant any right to terminate this Lease
or surrender possession of the Premises upon the transfer of Landlord's' interest.

 

19. COVENANT OF TITLE AND QUIET ENJOYMENT. Landlord covenants
and warrants to Tenant that Landlord has full right and lawful authority to enter into this Lease for the Term and that, provided
Tenant is not in default beyond any applicable notice and cure period, Tenant's quiet and peaceable enjoyment of the Premises shall
not be disturbed by Landlord or anyone claiming through Landlord. Tenant nevertheless acknowledges that portions of the Building
may be under construction following Tenant's occupancy of the Premises, and that such construction may result in levels of noise,
dust, obstruction of access, etc. which are in excess of that present in a fully constructed project. Tenant waives any and all
rent offsets or claims of constructive eviction which may arise in connection with such construction; provided, however, that Landlord
shall not materially impair, and shall use all commercially reasonable efforts to minimize any impact on, Tenant's business operations
and access to the Premises in the performance of such construction and shall seek to coordinate anticipated interruptions in services
or other disturbances with Tenant to the fullest extent possible.

 

20. RULES AND REGULATIONS.

 

20.1. Tenant's Obligation. Tenant shall be bound by
the Rules & Regulations. Landlord may, from time to time, make additional rules and regulations or modifications to the Rules
& Regulations which it deems reasonably necessary for the preservation of good order, safety, care, cleanliness and economical
management of the Premises. Landlord shall use commercially reasonable efforts to cause compliance in all material respects with
the Rules and Regulations by all tenants and other occupants of the Building; provided that: (i) Landlord shall in no event be
liable for non-compliance; (ii) any such non-compliance shall not excuse Tenant from compliance; and (iii) Landlord may permit
reasonable waivers so long as such waivers do not unreasonably interfere with or materially and adversely affect Tenant in the
conduct of its business or violate any express rights granted to Tenant under this Lease. Landlord shall not enforce the Rules
and Regulations against Tenant in a discriminatory manner.

 

20.2. Changes. Notwithstanding the above to the contrary:
(a) Tenant shall be provided with written notice of any change in the Rules & Regulations; (b) Tenant shall be required to
comply with only those Rules & Regulations which are applicable to all tenants in the Building; and (c) no change in the Rules
& Regulations shall be made that would materially and adversely affect Tenant's ability to use the Premises for the Permitted
Use.

 

21. EASEMENTS, RESTRICTIONS, AND RIGHTS OF WAY. The Premises
are leased subject to all easements, restrictions and rights-of-way legally affecting the Premises. Landlord has no actual notice
that these easements, restrictions, or rights-of-way prohibit the use of the Premises for the Permitted Use.

 

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22. LANDLORD'S RIGHT OF ENTRY. Subject to the Section
29 Landlord shall have the right to enter and to grant temporary licenses to enter the Premises in accordance with the
terms of this Section to inspect the Premises, to exhibit the Premises to prospective tenants (provided such is limited to the
period within one year prior to the Expiration Date ) or purchasers, to make alterations or repairs to the Premises or to the Building,
for any purpose which Landlord shall deem necessary for the operation and maintenance of the Building and the general welfare and
comfort of its tenants, or to abate any condition which constitutes a violation of any covenant or condition of this Lease. Landlord's
exercise of these rights shall not constitute an actual or constructive eviction. Notwithstanding the foregoing, except in case
of an emergency, Tenant may, at its option, bar Landlord from entry into certain areas of the Premises for bona fide confidentiality
or safety reasons. Except in the case of emergencies or default: (i) Landlord shall give Tenant at least 24 hours' advance written
notice (if the inspection relates to the Phase 1 Space or Phase 2 Space), and at least two business days’ advance written
notice of entry (if the inspection relates to the Phase 3 Space ) of entry; (ii) entries shall be during business hours; (iii)
any persons entering the Premises on behalf of Landlord shall be accompanied by one of Tenant's employees; and (iv) Landlord shall
make reasonable efforts to minimize interference with Tenant's occupancy of the Premises. Tenant shall permit NCSU and its contractors,
agents, and representatives to enter the Premises on the same terms provided to Landlord under this Section; provided that, in
the event of an emergency, when entry to the Premises is reasonably necessary and neither Tenant nor Landlord is personally present
to open and permit entry into the Premises, NCSU or NCSU's agent may enter the Premises by master key, code, card, or switch or
may forcibly enter the Premises, without rendering NCSU or such agents liable for such entry and without, in any manner, affecting
the obligations and covenants of this Lease.

 

23. LANDLORD'S LIABILITY. Notwithstanding anything in this
Lease to the contrary, none of the Landlord Parties shall be liable to Tenant for:

 

(a) Any damage caused by or any act or negligence of any other occupant
of the Building or by any owner or occupant of adjoining or contiguous property.

 

(b) Provided that causes of the damage are not directly under the
care, custody, or control of Landlord, any damage caused to Tenant or its property due to the Premises, Building, or Common Area
(or any part or appurtenances thereof) being or becoming out of repair or arising from the failure of any utility service. Tenant
shall promptly report any defective condition in or about the Premises, Building, or Common Areas known to it to Landlord.

 

None of the Landlord Parties shall have any personal liability for any breach of this
Lease or any claims relating to the relationship of the parties except to the extent of rental income, proceeds of sale, insurance
proceeds, condemnation proceeds, and the like received by the exculpated party from the Building after the entry of a judgment
in favor of Tenant and Tenant shall otherwise look solely to Landlord's interest in the Building for satisfaction. Any Landlord
who transfers its title to the Premises is relieved of all liability with respect to the obligations of Landlord under this Lease
to be performed on or after the date of transfer. Notwithstanding any other provisions in this Lease to the contrary, neither
Landlord nor Tenant shall be liable to the other for any special, consequential, incidental, or punitive damages except: (a) this
limitation shall not apply to a party's indemnification obligations; and (b) Tenant shall be liable for consequential damages with
respect to a breach of its obligations under Section 15.

 

24. IDENTITY OF INTEREST.  The relationship of the parties
during the Term shall at all times be only that of a landlord and tenant. Nothing in this Lease shall be deemed or construed to
have created the relationship of principal or agent or a partnership or joint venture between Landlord and Tenant.

 

25. FORCE MAJEURE. If Landlord or Tenant shall be delayed,
hindered or prevented from the performance of any act required under this Lease (other than the payment of money) by reason of
governmental restrictions, extreme weather or other act of God, scarcity of labor or materials, strikes, or any other reasons beyond
its reasonable control, the performance of the act shall be excused for the period of delay, and the period for the performance
of the act shall be extended for the period necessary to complete performance after the end of the period of the delay. If any
such force majeure extends for a period of 30 days or longer, it shall be treated as a casualty and the provisions of Section
13 shall apply.

 

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26. ATTORNEY FEES.  In the event that any legal action or
any other action is brought to enforce this Lease, the unsuccessful party in the proceeding shall pay to the successful party the
costs of the action, including reasonable attorneys' fees. "Reasonable Attorneys' Fees" shall be deemed
to be those fees actually charged based upon time actually spent at customary and reasonable charges normally incurred for those
type of services, as opposed to any statutory presumption which may then be in effect. This obligation shall survive a termination
of this Lease.

 

27. BROKER. Landlord shall: (i) be solely responsible for
any commissions due Landlord's Broker or other brokers contacted by or used by Landlord in connection with the negotiations or
execution of this Lease; and (ii) indemnify Tenant and hold Tenant harmless from and against any and all cost, expense, or liability
for commissions or other compensation or charges claimed by Landlord's Broker and any other broker or agent acting for Landlord
with respect to this Lease. Tenant shall: (i) be solely responsible for any commissions due any brokers contacted by or used by
Tenant in connection with the negotiations or execution of this Lease, other than Landlord's Broker, and (ii) indemnify Landlord
and hold Landlord harmless from and against any and all cost, expense, or liability for commissions or other compensation or charges
claimed by any broker or agent acting for Tenant with respect to this Lease.

 

28. HAZARDOUS SUBSTANCES.

 

28.1. Compliance. Tenant shall, at Tenant's own expense:
(a) comply with all Environmental Laws and the requirements of Exhibit J; (b) comply with the provisions of Section
11.1(e) of the Ground Lease applicable to a "Permitted Subtenant"; and (c) make all submissions to, provide all
information required by, and comply with all requirements of all governmental authorities (the "Authorities")
under the Environmental Laws arising in connection with its obligations under this Section.

 

28.2. Tenant's Restrictions. Tenant shall not cause
or permit to occur:

 

(a) Any violation of any Environmental Laws on, under, or about the Premises,
or arising from Tenant's use or occupancy of the Premises, including soil and ground water conditions; or

 

(b) The use, generation, release, manufacture, production, processing, storage,
or disposal of any Hazardous Substance on, under, or about the Premises, or the transportation to or from the Premises of any Hazardous
Substance, except: (i) in de minimis quantities necessary for or incidental to Tenant's normal and customary conduct of
business; and/or (ii) in strict compliance with all applicable Environmental Laws. Landlord acknowledges that Tenant will be using
the substances listed in Exhibit H in the Premises, which use shall nevertheless be in accordance with all applicable
governmental rules and regulations.

 

28.3. Remediation. Should any Authority or any third
party demand that a cleanup plan be prepared and that a cleanup be undertaken because of any deposit, spill, discharge, or other
release of Hazardous Substances that occurs at any time from Tenant's use or occupancy of the Premises, then Tenant, at its own
expense shall: (i) prepare and submit the required plans and all related bonds and other financial assurances; and (ii) carry out
all such cleanup plans.

 

28.4. Indemnification. Tenant shall indemnify, defend,
and hold harmless the Landlord Parties from all fines, suits, procedures, claims, and actions of every kind, and all costs associated
therewith (including reasonable attorneys' and consultants' fees) arising out of or in any way connected with any deposit, spill,
discharge, or other release of Hazardous Substances which: (a) occurs at or from the Premises during the Term of this Lease; (b)
arises at any time from Tenant's use or occupancy of the Premises; or (c) results from Tenant's failure to provide all information,
make all submissions, and take all steps required by all Authorities under the Environmental Laws. Tenant's obligations and liabilities
under this Section shall survive the termination of this Lease. These provisions relating to Tenant's environmental indemnification
obligations shall not apply to events: (i) which occur at any time as a direct result of the acts or omissions of Landlord, its
employees, agents, contractors, successors or assigns; (ii) which arise out of and are directly caused by events occurring before
Tenant took possession of the Premises; (iii) which occur after Landlord, its employees, agents, contractors, successors or assigns
have regained possession of the Premises; or (iv) which arise out of acts attributable to parties other than Tenant or its employees,
agents, contractors, or invitees. The burden of proving the applicability of an exception to Tenant's indemnification obligation
shall be on Tenant.

 

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29. PROPRIETARY INFORMATION. Landlord recognizes the need
for confidentiality and the proprietary nature of the work Tenant may, under license or contractual agreement, perform in the Premises
for itself or other third party research and development firms, and Landlord agrees to use all commercially reasonable efforts
to maintain the confidentiality of such work (including customer identity and relationships, products, business processes, equipment
configuration and specifications and any other development, production or manufacturing processes or activities) being performed
in the Premises. Without limiting the foregoing, Landlord shall inform any third parties entering the Premises with or at the request
or direction of Landlord of the proprietary and confidential nature of the work being performed therein, and, if requested by Tenant,
in writing, and Tenant is not then in default under the terms of this Lease beyond any applicable notice and cure period, Landlord
shall obtain from any such third party(ies) a commercially reasonable non-disclosure and non-competition agreement that is reasonably
acceptable to Tenant in form and substance, which shall be executed and delivered to Tenant prior to entry by that third party.

 

30. EFFECT OF TERMINATION. Upon a termination of this Lease,
neither party shall have any further obligations under this Lease except as to: (a) those obligations which have accrued on or
before the date of termination and remain unsatisfied; (b) the indemnification obligations set out in this Lease; and/or (c) any
obligations which by their nature would, or are expressly provided to, survive a termination of this Lease.

 

31. MISCELLANEOUS.

 

31.1. Interest. Any sums due to be paid by either party
to or for the benefit of the other which are not paid when due shall bear interest from the due date to the date of payment at
the lesser of the Interest Rate and the maximum legal interest rate permitted by law. Interest shall: (i) continue to accrue on
past due sums at the Interest Rate after an entry of judgment; (ii) shall not be payable on any late charges incurred by Tenant;
and (iii) not accrue if the payment is made in the applicable grace period provided under this Lease, if any.

 

31.2. Notices. To be effective, notices required under
this Lease must be in writing and must either be: (a) personally served (deemed received on receipt or refusal of delivery); (b)
delivered by a nationally recognized "next business day" express delivery service (deemed received the next business
day after posting); (c) posted by certified United States Mail, postage prepaid, return receipt requested (deemed received three
business days after posting); or (d) delivered via electronic mail (deemed received on receipt of transmission), provided, however,
that if such communication is given via electronic mail, an original counterpart of such communication shall concurrently be sent
in either manner specified above. Each document shall be addressed/transmitted as set out in the Lease Term Sheet or at such other
address as may from time to time be designated in writing in accordance with this Subsection.

A copy of any default notices required to be sent to Tenant under this Lease shall be
contemporaneously sent to:

 

Hutchison PLLC

3110 Edwards Mill Road

Suite 300

Attn: William N. Wofford

Email: bwofford@hutchlaw.com

 

A copy of any default notices required to be sent to Landlord under this Lease shall
be contemporaneously sent to:

 

Burns, Day & Presnell, P.A.

2626 Glenwood Avenue - Suite 560

Raleigh, North Carolina 27608

Attn: James M. Day

Email: jday@bdppa.com

 

    	 	26

     

    

 

Notices may be given on behalf of any party by that party's legal counsel and notices
on behalf of Landlord may be given by the Managing Agent. Notwithstanding anything in this Lease to the contrary: (i) Statements
and any demands for reimbursement may be posted by ordinary United States Mail; and (ii) parties to be copied on any notices need
be copied only on notices of default.

 

31.3. Recording.  This Lease shall not be recorded,
but a memorandum of it (in the form of Exhibit K) may, at the expense of the recording party, be prepared and recorded
in the County where the Premises are located.

 

31.4. Additional Acts. Each party will execute and
deliver all other additional and necessary instruments and documents and do all other acts and things as may be reasonably necessary
to more fully effectuate the transaction contemplated by this Lease.

 

31.5. Entire Agreement. This Lease constitutes the
entire and exclusive agreement between the parties with respect to the leasing of the Premises. All prior agreements between the
parties, whether oral or written, are merged into this document and shall be of no further force or effect. This Lease cannot be
changed, modified or discharged other than by a written agreement signed by the party against whom enforcement of the change, modification
or discharge is sought.

 

31.6. Binding Effect.  Each and all of the covenants,
terms, provisions, and agreements of this document shall be binding upon and inure to the benefit of the parties and, to the extent
permitted by this Lease, their respective heirs, executors, administrators, legal representatives, successors and assigns; provided
that Landlord shall have no obligation to Tenant's successor unless the rights or interests of Tenant's successor are acquired
in accordance with the terms of this Lease.

 

31.7. Waiver. The delay or failure of either party
to seek redress for violation of or to insist upon the strict performance of any covenant or condition of this Lease shall not
prevent a prior or subsequent act, which would have originally constituted a violation, from having the effect of an original violation.
Any waiver by a party of any breach or default by the other must be in writing and will be effective only to the extent specifically
set forth in that writing. Except as subsequently may be expressly acknowledged in writing by Landlord, no acceptance of Rent by
Landlord after an Event of Default shall constitute a waiver by Landlord of any Event of Default or otherwise reinstate, continue,
or extend the Term or affect any notice of termination given to Tenant prior to Landlord's receipt of such payment. No statement
on a payment check from Tenant or in a letter accompanying a payment shall be binding on Landlord and Landlord may, with or without
notice to Tenant, accept such payment and/or negotiate such check without being bound to the conditions of such statement.

 

31.8. Binding Arbitration. Except for any court action:
(i) seeking injunctive relief (e.g., summary ejectment), in which case such action shall be strictly limited to such matters only;
(ii) seeking to challenge the enforceability of the binding arbitration provisions of this Lease; or (iii) filed after a court
of competent jurisdiction has declared such arbitration provisions to be unenforceable, all controversies and disputes between
the parties arising out of or related to this Lease or the relationship of the parties under this Lease, irrespective of the type
of claim, shall be determined by binding arbitration under the North Carolina Revised Uniform Arbitration Act (the "Act").
The decision of the arbitrator shall be final and binding on all parties to that proceeding and a judgment upon the arbitrator's
award may be entered in any court having jurisdiction thereof. Except as expressly provided otherwise in this Lease, a party may
initiate an arbitration proceeding by sending written notice of such (the "Arbitration Demand") to the
other Party at any time prior to the date the claim is barred by the applicable statute of limitations. That notice shall specify
the nature of the dispute. The arbitration shall be held in Raleigh, North Carolina. Notwithstanding any provisions of the Act
to the contrary: (a) the parties shall be entitled to conduct discovery as provided under the North Carolina Rules of Civil Procedure
so long as that discovery is concluded within 90 days of the date of the Arbitration Demand; (b) the parties shall comply with
Rule 3 (b) - (d) of the Rules for Court-Ordered Arbitration in North Carolina; and (c) the arbitrator shall have the authority
to award injunctive relief and to impose sanctions under NCRCP Rule 11 and other applicable rules. All disputes relating to discovery
which cannot immediately be resolved by the parties shall be submitted to the arbitrator for an expedited ruling. The arbitration
shall be conducted by a single arbitrator mutually acceptable to the parties, or, if the parties are unable to agree upon a single
arbitrator within 20 days of the date of the Arbitration Demand, then by a single arbitrator appointed by a Wake County Superior
Court Judge. Unless the arbitrator awards otherwise, the cost of the arbitration shall be ratably borne by the parties to the proceeding.

 

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31.9. Jurisdiction. This Lease shall be deemed executed
and completed in North Carolina; the courts of North Carolina shall have exclusive jurisdiction over any matters (including torts)
relating to or arising out of this Lease or the relationship of the parties under this Lease; and by their signatures below, the
parties consent to the exclusive, personal jurisdiction by the courts of North Carolina and to venue in Wake County, North Carolina
and irrevocably waive any objection thereto.

 

31.10. Time. Time is of the essence in connection with
each and every provision of this Lease. If any time period under this Lease ends on a Saturday, Sunday, or any day on which the
state courts of Wake County, North Carolina are closed, that time period shall be extended until the next business day.

 

31.11. Representations and Warranties. Each party,
for itself, represents and warrants to the other that:

 

(i) It is duly constituted, in good standing, and qualified to do business
in the State of North Carolina; it has the right, power, and authority to enter into this Lease and all related documents to be
executed by it (collectively, the "Lease Documents") and to perform its obligations under the Lease Documents,
as written; the execution and delivery of the Lease Documents have been duly authorized and the signatories signing on its behalf
have the requisite authority to bind it to the obligations under the Lease Documents; and the Lease Documents constitute its valid
and legally binding obligations, enforceable against it in accordance with their terms;

 

(ii) The execution and delivery of the Lease Documents, and the performance
of its duties and obligations under the Lease Documents and of all other acts necessary and appropriate for the full consummation
of this Lease, are consistent with and not in violation of any contract, agreement or other instrument to which it is a party,
or any judicial order or judgment of any nature by which it is bound; and

 

(iii) It is not, and will not become, an entity with whom U.S. persons are
restricted from doing business under the regulations of the Office of Foreign Asset Control ("OFAC") of
the Department of Treasury (including those named on OFAC's Specially Designated and Blocked Persons list) or under any statute,
executive order (including the September 24, 2001 Executive Order Blocking Property and Prohibiting Transactions With Persons Who
Commit, Threaten to Commit, or Support Terrorism), the USA Patriot Act, or other governmental action.

 

The foregoing representations and warranties are made by each party with the knowledge
and expectation that the other is placing complete reliance thereon and shall survive the execution of this Lease. Each party will
not cause or permit any action to be taken which will cause any of its representations or warranties to be untrue. Each party agrees
to indemnify and hold the other harmless from all liabilities, claims, losses, damages, and expenses (including reasonable attorneys'
fees) relating to or arising out of a breach of these representations and warranties. This indemnification obligation shall survive
the termination of this Lease.

 

33. ADDITIONAL LEASE PROVISIONS. Additional provisions of
this Lease are contained in the attached Exhibits. These additional provisions shall control if in conflict with any of the foregoing
provisions of this Lease.

 

 

 

 

[Signatures on Next Page]

 

    	 	28

     

    

 

IN WITNESS WHEREOF, the undersigned have executed, sealed, and delivered this
Lease as of the date first above written.

 

		

 

 

 

 

 

 

 

 

    	 	29

     

    

 

EXHIBIT A

PREMISES DESCRIPTION

 

 

     

     

    

 

 

    	 	ii

     

    

 

 

    	 	iii

     

    

 

EXHIBIT B

RENEWAL
OPTION

 

Provided Tenant complies with all terms and conditions of this Lease
and, at the time of exercise, there is not a continuing Event of Default or a material Default (provided that any Default still
within the cure period is subsequently cured within the applicable cure period), Tenant shall have two options to renew this Lease
(each a "Renewal Option"), for an additional five years each (each a "Renewal Term").
Each Renewal Term shall be on the same terms and conditions of this Lease, including the Base Rent as provided in Exhibit
F. If Tenant elects to exercise a Renewal Option, it shall give written notice to Landlord at least 365 days' prior to
the then scheduled Expiration Date. Provided a Renewal Option has been properly exercised, it shall be irrevocable and wherever
the term "Term" appears in this Lease, it shall include the exercised Renewal Term and the Expiration Date shall
be extended for the length of that exercised Renewal Term. The Renewal Options are personal to the original Tenant and shall automatically
expire on an assignment of this Lease or a subletting of the Premises by the original Tenant, except in the case of an assignment
to an Affiliated Entity. The failure of Tenant to timely and properly exercise the first Renewal Option shall automatically void
all subsequent Renewal Options granted under this Exhibit.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

     

     

    

 

EXHIBIT C

BUILDING IMPROVEMENTS

 

The Building will be delivered in a "warm shell" condition and include the
following:

 

Location: The Building is located within NCSU's Centennial Campus on the corner
of Research Drive and Main Campus Drive.

 

LEED Certification: The shell of the Building will be designed and constructed
as a LEED Silver building incorporating energy efficient design and sustainable features.

 

Space: The Building will be three stories and contain approximately 104,998 rentable
square feet (107,598 gross square feet). The first floor consists of high bay industrial space and will house part of the NCSU
NonWovens Institute, while the other two floors will be leasable shell office/laboratory space.

 

Construction: The Building will be constructed as a Type II B- Fully Sprinkled

 

Structural System: Composite steel frame and concrete floor slab system. The upper
leasable floors in the Building will be designed for 100 lb. /sf floor loading. The floor to floor heights at these levels will
be approximately 15'-4".

 

Exterior facade: The exterior walls will be constructed of brick veneer masonry
with aluminum panel detailing over 2" rigid insulation on metal studs with 2" spray foam in the cavity.

 

Curtain Wall: Pre-finished aluminum curtainwall system with 1" tinted insulated
high performance glass with low-e coating.

 

Windows: The window system is a thermally improved aluminum framing system with
1" insulated high performance glass. Windows typically start at 2'-0" above finished floor and extend to 9'-0" AFF.
Windows will receive 1" mini blinds mounted in frame.

 

Roof: Single-ply mechanically fastened TPO roof membrane over mechanically fastened
R-30 insulation.

 

Shared Common Areas: 

 

-- 1st Floor Common Areas: The first floor is accessed from the drive
off of Research Drive and the adjacent parking deck. There is a shared exterior dock for truck access and a wide corridor that
leads to the service elevator and elevator lobby. This first floor elevator lobby contains terrazzo floors, painted walls, accent
wood paneling, and electronic building directory. Tenant mailboxes, modern restrooms, and stairs are also located directly off
this lobby.

 

-- 2nd Floor Common Areas: The second floor is accessed from two separate
sides of the Building. One access is along Main Campus Drive and contains the larger formal building lobby. This two-story lobby
contains terrazzo floors, painted walls, accent wood paneling, open ceiling with acoustical clouds, and a state of the art electronic
building directory. An open stairwell in the middle of this lobby leads to a lounge area with a large screen television, seating,
vending machines, and a large custom piece of artwork. The other side of the second floor is accessed from a bridge that spans
from the adjacent parking deck to the Building. This side has an elevator lobby similar in size to the ground floor elevator lobby.
This first floor elevator lobby contains terrazzo floors, painted walls, accent wood paneling, and a state of the art electronic
building directory for way-finding. Modern restrooms are located off a shared corridor.

 

-- 3rd Floor Common Area: The majority of the third floor is intended
for tenant use. There is a restroom core and this floor is served by two egress stairs.

 

     

     

    

 

Elevators: Two traction passenger elevators will be provided: (i) an elevator
with a capacity of 3500 pounds and a speed of 150 fpm; and (ii) a larger 4500 pound service elevator. The elevator cabs will have
custom cab wall treatments with polished stainless steel ceiling and flooring to match lobby.

 

Parking Deck: The parking deck will contain approximately 284 parking spaces.
It will be constructed of precast concrete throughout, with the front of the deck facing Research Drive receiving a brick façade
that compliments the adjacent building's architectural design. There are two stairs for vertical circulation, and a bridge on the
highest level that connects to the 2nd floor of the Building over the access drive. There will be controlled gate access within
this parking deck.

 

Mechanical System: The mechanical system includes all heating, ventilating, and
cooling equipment and associated electrical and control wiring to supply conditioned air. The Building is served by chilled water
and gas-fired condensing boilers (for preheat). Heating and air conditioning for the Building will be provided by chilled-water
rooftop units. Medium pressure duct and exterior fan-powered box (FPB) units with electric reheat are installed for exterior exposures.

 

Each FPB unit contains a damper that modulates to control the amount of air delivered
to the space it is serving. The damper position is controlled by the space thermostat. During the cooling season the cooled air
shall be approximately 55o F. During the heating season the damper closes to a minimum position and the integral fan is powered
on. The fan pulls air from the return air plenum and pushes air across the electric heating coils. This heated air is delivered
to the space until the thermostat setpoint is met.

 

Tenants with spaces other than a typical office may require additional supplemental units
and/or exhaust systems in their fit-up. Variable air volume boxes (dampers that serve interior areas) will be part of the tenant
upfit.

 

Energy Management System: Computerized DDC energy management system and controls
providing maximum comfort and minimizing energy consumption.

 

Plumbing System: A complete system of plumbing will be installed, consisting of
sanitary drainage, storm drainage, and hot and cold water throughout the Building. Restrooms will be provided with auto-flush valve
and infrared touch-less faucets.

 

Fire Protection System: The Building will be fully sprinkled per NFPA 13. Sprinkler
heads in lay-in ceilings will be the white semi-recessed type and be installed centered in ceiling tiles. Sprinkler heads will
be installed turned up in the tenant spaces due to the lack of a ceiling and then turned down as part of a tenant upfit.

 

Electrical System: The main service for the 2nd and 3rd floors of the Building
is a 277/480V 2500 amp main switchboard and distribution panels for HVAC, lighting and convenience power are installed.

Each floor is fed via a 400 amp HVAC and a 400 amp lighting panel which are 277/480V.
The lighting panel in turn feeds two 75kVA transformers on each floor and two 120V panels per transformer for power. Each panel
is protected via a TVSS.

 

Fire Alarm: The Building will be equipped with a state of the art addressable
fire alarm system, which is monitored 24 hours per day, 7 days a week.

 

Shell Tenant Space:

 

		·	Floors will be broom clean concrete, ready for floor finish.

		·	Core walls in the space and the tenant-side of exterior walls will be bare (i.e., not be finished with gypsum board).

		·	The ceiling is designed to be installed at approximately 9'-0" AFF, with opportunities to go higher in some areas.

		·	Emergency lighting only.

 

    	 	ii

     

    

 

EXHIBIT D

TENANT UPFIT

 

The plans and specification for the Tenant Upfit shall be subject
to the reasonable approval of both parties. A copy of those approved plans and specification (the "Approved Plans &
Specs") shall be initialed by each party in a separate instrument. If, despite reasonable efforts, the parties cannot
agree on the Plans & Specs before the Plans & Specs Deadline, either party, as its sole and exclusive remedy, may submit
such dispute to binding arbitration as contemplated under Section 31.8. Once approved, no material changes to the
Approved Plans & Specs may be made without both parties' reasonable prior written consent. All approved changes shall be made
in the form of a written change order (a "Change Order") setting forth the increased costs and/or anticipated
delay in completion, if any, caused by that Change Order. Tenant shall reimburse Landlord for any increased costs, including
any applicable supervision fees, resulting from a Change Order requested by Tenant within 20 days of Tenant's receipt of the invoice
from Landlord for those increased costs.

 

The Tenant Upfit Budget shall be subject to the reasonable approval
of both parties and shall include the CS Fee (defined below). Landlord shall use Danis Construction Company, LLC as the general
contractor for the construction of the Tenant Upfit (the "GC"). As requested by Tenant, for each subcontract
expected to exceed $50,000 in cost, Landlord shall require the GC to obtain up to three bids (each, a "Bid")
from reputable, licensed subcontractors (the "Bidders") it proposes to use in connection with the construction
of the Tenant Upfit. Each Bid shall separately identify a total construction cost for that Bidder's portion of the Tenant Upfit.
Landlord shall provide copies of the Bids, along with each Bidder it has selected for the construction of the Tenant Upfit, to
Tenant. Tenant shall have 10 days after its receipt of the Bids to notify Landlord, in writing, of its approval of, or objection
to, the Bidders selected by Landlord. If, despite reasonable efforts, the parties cannot agree on the Tenant Upfit Budget or all
of the Bidders by the Budget Approval Deadline, either party, as its sole and exclusive remedy, may submit such dispute to binding
arbitration as contemplated under Section 31.8.

 

The Managing Agent shall receive a fee for its supervision of the
construction of the Tenant Upfit (the "CS Fee"). The total CS Fee due from Tenant shall equal the lesser
of: (i) 5.0% of all hard costs incurred in the construction of the Tenant Upfit; and (ii) $250,000.00 (the "Cap").
For this purpose, the items to be included in "hard costs" shall be those items identified as such in the mutually
approved Tenant Upfit Budget. The CS Fees shall be earned throughout the construction period and paid in installments (the "CSF
Installments") as and when the GC is paid for the costs it has incurred in constructing the Tenant Upfit. Until the
Cap is reached, each CSF Installment shall equal 5.0% of the draw request filed by the GC under its construction contract with
Landlord and shall be paid within 15 days of the GC's submission of each draw request. To the extent sufficient funds remain in
the Tenant Upfit Allowance, the CSF Installments shall be paid to Manager by Landlord and such amounts credited as payments of
the Tenant Upfit Allowance. To the extent necessary, thereafter the CSF Installments shall be paid to Manager by Tenant within
15 days of the GC's submission of each subsequent draw request.

 

     

     

    

 

EXHIBIT E

CONSTRUCTION SCHEDULE

 

CS-1. In addition to other terms defined elsewhere in this Lease, the following
capitalized words and phrases shall have the indicated meanings in this Lease unless the context otherwise requires:

 

Target Phase I Space Delivery Date: February 15, 2017

 

Target Phase II Space Delivery Date:  May 16, 2017

 

Target Phase III Space Delivery Date:  July 31, 2017

 

Outside Delivery Date: June 16, 2017 for the Phase II Space and August
31, 2017 for the Phase III Space

 

Tenant Delays: Delays in completion of the Tenant Upfit caused by or
attributable to Tenant.

 

Landlord Delays: Delays in completion of the Tenant Upfit caused by
or attributable to Landlord.

 

Substantial Completion/Substantially Completed: When a Phase may be
lawfully occupied by Tenant (i.e., a certificate of occupancy or temporary certificate of occupancy has been issued) for the normal
conduct of its business, notwithstanding that minor or insubstantial details of construction, decoration, or mechanical adjustment
remain to be performed.

 

CS-2. Landlord shall use commercially reasonable efforts to cause the Tenant Upfit
for each Phase to be Substantially Completed by the applicable delivery date specified in this Exhibit (each a "Target
Delivery Date") and, in any event, for the applicable Outside Delivery Date. Each of these dates shall automatically
be extended for the following (the "Permitted Delays"): (a) Tenant Delays (including Tenant's failure to
provide Landlord with everything reasonably necessary to reasonably enable Landlord to complete the construction drawings for the
Premises by the Plans & Specs Deadline, (provided that Tenant has a minimum of 10 business days to review the construction
budget), and Tenant Change Orders); (b) delays in construction caused by weather; (c) each day in excess of 30 days after Landlord's
application that it takes Landlord to get the building permit for the Tenant Upfit; (d) delays in construction caused by the unavailability
of construction materials or equipment due to causes beyond Landlord's reasonable control; and/or (e) delays in governmental approvals.

 

CS-3. Landlord shall deliver possession of each Phase to Tenant promptly after
it has Substantially Completed the Tenant Upfit applicable to that Phase. A delay in Landlord's delivery of a Phase by its Target
Delivery Date shall not affect the validity of this Lease or Tenant's obligations under this Lease, nor, except as provided in
Section CS-5, shall Landlord be subject to any liability for that delay. Notwithstanding anything in this Lease to
the contrary, Tenant's sole and exclusive remedy for Landlord's failure to deliver a Phase by its Target Delivery Date shall be
as provided in Section CS-5 below. Landlord and Tenant agree to confirm the actual delivery date for each Phase,
in writing, prior to Tenant's occupancy of that Phase.

 

CS-4. If Substantial Completion for Phase II is delayed past its Target Delivery
Date due to Tenant Delays, Tenant shall pay to Landlord an amount equal to the Per Diem Rent, for each day of delay in Substantial
Completion caused by those Tenant Delays (the "Delay Rent"). (For example, if the date of Substantial
Completion is 15 days past the Target Commencement Date and ten of those days of delay are attributable to Tenant Delays, the Delay
Rent to be paid by Tenant shall equal 10 days' worth of Per Diem Rent.) In that event, the payment of the first month's Rent
due under this Lease shall be accompanied by payment of the Delay Rent.

 

CS-5. If the Target Delivery Date for a Phase has not occurred until after that
Phase's applicable Outside Delivery Date other than because of Permitted Delays, Tenant shall, as its sole remedy, receive a credit
against the Base Rent otherwise due, calculated as provided below, for each day of delay in Substantial Completion past the applicable
Outside Delivery Date caused by Landlord Delays (the "Delay Credit"). This Delay Credit shall be calculated
as follows: (i) for each of the first 45 days actual delivery is delayed past its Outside Delivery Date, an amount equal to 50%
of the Per Diem Rent; and (ii) thereafter for each day actual delivery is delayed past its Outside Delivery Date, an amount equal
to the Per Diem Rent. In that event, the payments of Base Rent due under this Lease shall be credited for the amount of the Delay
Credit until such time as the total amount of the Delay Credit is exhausted. The Delay Credit shall be Tenant's sole and exclusive
remedy for Landlord's failure to meet an Outside Delivery Date.

 

     

     

    

 

CS-6. Landlord shall provide any updates to the Construction Schedule to Tenant
promptly after any changes and no less often than every other week.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	ii

     

    

 

EXHIBIT F

BASE RENT SCHEDULE

 

	LEASE PERIOD (Mos.)*	INSTALLMENT AMOUNT**	PAYMENT AMOUNT**
	 	 	 	 	 	 
	 	01 - 03	 	$87,576.67/mo.	 	$43,788.33/mo.
	 	04 - 15	 	$87,576.67/mo.	 	$87,576.67/mo.
	 	16 - 27	 	$90,203.97/mo.	 	$90,203.97/mo.
	 	28 - 39	 	$92,910.09/mo.	 	$92,910.09/mo.
	 	40 - 51	 	$95,697.39 /mo.	 	$95,697.39 /mo.
	 	52 - 63	 	$98,568.31 /mo.	 	$98,568.31 /mo.
	 	64 - 75	 	$101,525.36/mo.	 	$101,525.36/mo.
	 	76 - 87	 	$104,571.12/mo.	 	$104,571.12mo.
	 	88 - 99	 	$107,708.25/mo.	 	$107,708.25/mo.
	 	100 - 111	 	$110,939.50 /mo.	 	$110,939.50 /mo.
	 	112 - 123***	 	$114,267.69/mo.	 	$114,267.69/mo.
	 	124 - 135	 	$117,695.72 /mo.	 	$117,695.72 mo.
	 	136 - 147	 	$121,226.59 /mo.	 	$121,226.59 /mo.
	 	148 - 159	 	$124,863.39 /mo.	 	$124,863.39 /mo.
	 	160 - 171	 	$128,609.29 /mo.	 	$128,609.29 mo.
	 	172 - 183***	 	$132,467.57 /mo.	 	$132,467.57 /mo.
	 	184 - 195	 	$136,441.59 /mo.	 	$136,441.59 mo.
	 	196 - 207	 	$140,534.84.	 	$140,534.84 /mo.
	 	208 - 219	 	$144,750.89 /mo.	 	$144,750.89 /mo.
	 	220 - 231	 	$149,093.41 /mo.	 	$149,093.41 /mo.
	 	232 - 243	 	$153,566.22 /mo.	 	$153,566.22 mo.

 

 

* The "Lease Periods" are calculated from the Rent Commencement Date. For
avoidance of doubt purposes, the parties acknowledge that: (i) Tenant shall not pay Base Rent or Additional Rent for the Phase
I Space until the Phase II Space is delivered to Tenant (i.e., the Rent Commencement Date); and (ii) Tenant shall pay Base Rent
and Additional Rent for the entire Premises on and after the Rent Commencement, notwithstanding that the delivery of the Phase
III Space will not be until sometime after that date. 

 

**The Installment Amounts reflect the stated amount of Base Rent payment to be paid
by Tenant each month of the Term and the Payment Amounts reflect the actual amount of Base Rent payment to be paid by Tenant each
month of the Term after factoring in the Rent Abatement. 

 

***Rent after the 123rd month through the 183rd month is applicable
only if Tenant timely and properly exercises the first Renewal Option. Rent after the 183rd month through the 243rd
month is applicable only if Tenant timely and properly exercises the second Renewal Option.

 

 

 

     

     

    

 

EXHIBIT G

LETTER OF CREDIT TERMS

 

If Tenant elects to fund the Security Deposit with a Letter of Credit,
the following terms and conditions shall be applicable:

 

LCT-1. DEFINITIONS: For purposes of this Exhibit, the following terms shall have
the indicated meanings:

 

"ADAPT Study"
refers to that clinical trial called "The Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of
Advanced Renal Cell Carcinoma".

 

"Cash Assets" refers
to the amount of Tenant's cash assets as of the date of calculation.

 

"Cash Burn Rate"
refers to Tenant's average monthly decrease in capital projected over the ensuing 12-month period as of the date of calculation.

 

"Cash Certification"
means a written certification, signed by an officer of Tenant, of the Cash Assets and the Cash Runway as of the date of
certification.

 

"Cash Runway"
refers to the Cash Assets divided by the projected Cash Burn Rate as of the date of calculation. (For
example, if as of the date of calculation the Cash Assets are $40,000,000 and the 12-months forward Cash Burn Rate is projected
at $3,000,000 per month, the Cash Runway would be 13.33 months.)

 

"Credit Amount" refers to the amount of
the Letter of Credit .

 

"IDMC" refers to the Independent Data Monitoring
Committee.

 

"Issuer" refers to the issuer of the Letter
of Credit as of the date of determination.

 

"Maximum Draw Amount" is defined in Section
LTC-3.1.

 

"Minimum Cash Balance"
means the sum of $36,000,000.

 

"Performance Benchmark" refers to at least
a four-month improvement in survival rates attributable to Tenant's drug, as compared to the control arm, as reflected in the topline
read-out of the final data from the ADAPT Study.

 

"Qualified Issuer" means a commercial bank:
(i) which is either a duly chartered national banking association or a duly chartered North Carolina state banking with offices
in Raleigh, NC; (ii) which is insured by the Federal Deposit Insurance Corporation; (iii) whose long-term, unsecured and unsubordinated
debt obligations are, at issuance of the Letter of Credit and thereafter, rated in the highest category by at least two of the
Rating Agencies (i.e., currently "AAA" for Fitch, "Aaa" for Moody's, and "AAA"
for S&P); and (iv) which has, at issuance of the Letter of Credit and thereafter, a short term deposit rating in the highest
category for at least two Rating Agencies (i.e., currently "F1" for Fitch, "P-1" for Moody's,
and "A-1" for S&P)

 

"Rating Agencies" refers to Fitch Ratings
Ltd. ("Fitch"), Moody's Investors Service, Inc. ("Moody's"), and Standard &
Poor's Ratings Services ("S&P"), or their respective successors.

 

"SD Condition" refers to each benchmark
described in Section LCT-3 that must be satisfied to warrant a change in the amount of the Security Deposit.

 

"SEC Reports" refers to Tenant's Quarterly
10-Q Report or Tenant's Annual 10-K Report, as the case may be, filed with the SEC.

 

     

     

    

 

"Supporting Documentation" refers to documentation
confirming that the applicable SD Condition has been satisfied, including the following:

 

(i) SEC Reports, which Tenant shall provide copies of to Landlord within 10
business days of each filing with the SEC;

 

(ii) Written confirmation from an authorized representative of the IDMC; and

 

(iii) Cash Certifications, which shall be provided to Landlord on a monthly
basis, within 10 business days after the end of each calendar month.

 

LCT-2. LETTER OF CREDIT:

 

2.1. Terms. Except where Landlord otherwise agrees,
in its sole discretion: (i) the Credit Amount shall be fixed at $2,400,000.00 for the entire Term; and (ii) the Letter of Credit
must be in the form attached as Exhibit G-1.

 

2.2. Maintenance of Letter of Credit. Tenant shall,
at its sole expense: (a) keep the Letter of Credit in place for as long as a Security Deposit is required under the terms of this
Lease; and (b) cause the Letter of Credit to be amended, replaced, or re-issued in substantially the same form if: (i) Landlord
changes its notice address; (ii) Landlord collaterally assigns the Letter of Credit to the Landlord's Lender or transfers the Letter
of Credit to a Successor; (iii) the original Letter of Credit is lost, stolen, mutilated, or destroyed; and (iv) each time, if
ever, the Credit Amount changes.

 

2.3. Landlord Draws. Landlord shall be authorized
to draw on the Letter of Credit: (a) as provided in Section 6.1; (b) if Tenant fails to renew or replace the Letter
of Credit within ten business days after the Issuer notifies Landlord that Issuer is not renewing the Letter of Credit; or (c)
notwithstanding anything in this Lease to the contrary, immediately, without further notice to Tenant or opportunity to cure, upon
a filing of voluntary bankruptcy by, or involuntary bankruptcy against, Tenant. In the case of (b) or (c) above, Landlord may,
in its discretion, immediately draw the full amount of the Letter of Credit and either: (i) treat such event as an immediate Event
of Default, with no further notice or cure periods, and apply the cash received from that draw towards payment of all amounts recoverable
by Landlord under Section 17.2; or (ii) not terminate the Lease; but credit the cash received from that draw against
the amount of the Security Deposit required of Tenant under this Lease.

 

LCT-3. MAXIMUM DRAW AMOUNT: Notwithstanding the Credit Amount or anything in this
Lease to the contrary, the maximum amount drawable by Landlord under the Letter of Credit (the "Maximum Draw Amount")
as of a particular date shall be determined as follows:

 

3.1. Calculation Formulas. 

 

(a) The initial Maximum Draw Amount shall be $2,400,000.

 

(b) If the IDMC determines at its February 2017 meeting that,
based on positive test results, the ADAPT Study should continue, and provides written confirmation of that determination to Landlord,
the Maximum Draw Amount shall be reduced to $1,800,000.

 

(c) If by July 31, 2017 both: (i) the Performance Benchmark
has been met; and (ii) Tenant has, since February 1, 2017, received at least $70,000,000 in a combination of equity capital and/or
upfront proceeds from a partnership with a third party, the Maximum Draw Amount shall be reduced to $1,200,000.

 

(d) Starting with the SEC Report for the quarter ending June
30, 2017, if as of the date of the SEC Report (i.e., each end of calendar quarter), the Cash Runway reflected in the Cash Certification
for that same date is 12 months or greater, the Maximum Draw Amount shall be $1,200,000.

 

(e) If after the 40th full month of the Term Tenant
continuously maintains a Cash Runway of not less than 12 months, the Maximum Draw Amount shall be reduced, on an annual basis,
as follows:

 

    	 	ii

     

    

 

	Adjustment Date 	Maximum Draw Amount
	 	 	 
	End of 52nd full month of the Term	$  1,000,000	 
	End of 64th full month of the Term	$     800,000	 
	End of 76th full month of the Term	$     600,000	 
	End of 88th full month of the Term	$     400,000	 
	End of 100th full month of the Term	$     200,000	 

 

(For avoidance of doubt purposes, the Maximum Draw Amount can never be reduced below
$200,000 pursuant to this subparagraph (e).) If at any Adjustment Date the Cash Runway is less than 12 months, no further adjustments
in the Maximum Draw Amount shall be made as otherwise contemplated above, and the amount of Maximum Draw Amount shall be determined
as provided under Section LTC-3.2.

 

3.2. Formula Exceptions. Notwithstanding Section
LTC-3.1 to the contrary:

 

(a) If as of the date of an SEC Report (i.e., each end of
calendar quarter), the Cash Runway reflected in the Cash Certification for that same date is less than 12 months, the Maximum Draw
Amount shall be set at the amount called for in the following chart:

 

	Cash Runway	 	Maximum Draw Amount 
	9 months or greater, but less than 12 months	 	$1,500,000
	6 months or greater, but less than 9 months	 	$1,800,000
	3 months or greater, but less than 6 months	 	$2,100,000
	Less than 3 months	 	$2,400,000

 

The provisions of this Section LTC-3.2(a) control all of the provisions
in Section LTC-3.1.

 

(b) If a Cash Certification reflects that Tenant's Cash Assets
are less than the Minimum Cash Balance, the Maximum Draw Amount shall be $2,400,000. The provisions of this Section LTC-3.2(b)
control the provisions in Section LTC-3.2(a) and all of the provisions in Section LTC-3.1.

 

(c) No decease in the Maximum Draw Amount otherwise contemplated
to take effect pursuant to this Section or Section LTC-3.1 shall be made if, at the time the adjustment was to be
made, an Event of Default has occurred and is continuing under this Lease. The provisions of this Section LTC-3.2(c)
control the provisions in Section LTC-3.2(a) & (b) and all of the provisions in Section LTC-3.1.

 

(d) As of the date an Insolvency Proceeding occurs with respect
to Tenant, the Maximum Draw Amount shall immediately become, and remain at, $2,400,000.00. The provisions of this Section
LTC-3.2(d) control all other provisions in Section LTC-3.

 

3.3. Changes. Each change in the Maximum Draw Amount
mandated under this Exhibit shall be effective, automatically, as of the first day of the calendar month following the satisfaction
of the SD Condition. Within 10 days after each receipt of Supporting Documentation from Tenant or at such other times as Landlord
determines that a change in the Maximum Draw Amount is mandated under this Exhibit, Landlord shall send its calculation of the
then required Maximum Draw Amount to Tenant. If Tenant disputes Landlord's calculation of the Maximum Draw Amount, at any time
within the 10 days after its receipt or deemed receipt of that calculation, Tenant may serve written notice on Landlord demanding
arbitration of that dispute. The Maximum Draw Amount as ordered by the arbitrator's decision shall be effective as of the date
of that decision. If there is no timely demand for arbitration, that Maximum Draw Amount calculated by Landlord shall be deemed
correct in all respects and shall no longer be open to challenge by Tenant.

 

LCT-4. ISSUER DEFAULT: If at any time: (i) the Issuer is no longer a Qualified
Issuer; or (ii) the Issuer's financial condition changes in any other materially adverse way (as determined by Landlord in its
sole discretion), within five business days after its receipt of written notice of such from Landlord, Tenant shall deliver to
Landlord a replacement Letter of Credit which is issued by another Qualified Issuer and which otherwise meets the requirements
of this Exhibit. Notwithstanding anything in this Lease to the contrary, if Tenant fails to timely deliver the replacement Letter
of Credit, Landlord may, in its discretion, immediately draw the full amount of the Letter of Credit and either: (a) treat such
event as an immediate Event of Default, with no further notice or cure periods, and apply the cash received from that draw towards
payment of all amounts recoverable by Landlord under Section 17.2; or (b) not terminate the Lease; but credit cash
received from that draw against the amount of the Security Deposit required of Tenant under this Lease.

 

    	 	iii

     

    

 

LCT-5. GENERAL:

 

(a) Tenant shall be solely responsible for any and all costs
and bank charges associated with the issuance of the original Letter of Credit and each assignment, transfer, renewal, amendment,
replacement, or re-issuance of the Letter of Credit. Payment of those fees shall not, however, be a condition to the exercise of
Landlord's rights under the Letter of Credit.

 

(b) All calculations of Cash Assets and Cash Burn Rate required
to be made under this Exhibit shall be made based on the figures reflected in the SEC Reports.

 

(c) The calculation of the Maximum Draw Amount shall be a
"point in time" calculation (i.e., the amount drawable as of the date of determination) and such calculation shall
not include any draws taken by Landlord under the Letter of Credit prior to the date of that calculation.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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EXHIBIT G - 1

FORM OF LETTER OF CREDIT

 

 

     

     

    

 

 

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EXHIBIT H

RULES AND REGULATIONS

 

 

Tenant shall faithfully observe and comply with the following Rules
and Regulations. Landlord shall not be responsible to Tenant for the nonperformance of any of these Rules and Regulations by, or
otherwise with respect to the acts or omissions of, any other tenants or occupants of the Building.

 

(1)       The sidewalks, walks,
plaza entries, corridors, concourses, ramps, staircases, escalators, and elevators shall not be obstructed or used by Tenant, or
any person entering the Building under express or implied invitation of Tenant, for any purpose other than ingress and egress to
and from the Premises. Except for those used in connection with Tenant's research being conducted at the Premises, no vehicle shall
be brought into the Building or kept on the Premises without Landlord's prior written consent.

 

(2)       After the Rent Commencement
Date, no freight, furniture, or bulky matter (not in the ordinary course of business) of any description shall be received into
the Building or carried into the elevators except in such a manner, during such hours, and using such elevators and passageways
as may be reasonably approved by Landlord, and then only upon having been scheduled in advance. Any hand trucks, carryalls, or
similar appliances used for the delivery or receipt of merchandise or equipment shall be equipped with rubber tires, side guards
and such other safeguards as Landlord shall require.

 

(3)       At the time of Tenant
Upfit or any Alterations, Landlord shall have the right to prescribe the weight, position, and manner of installation of safes,
concentrated filing/storage systems, or other heavy equipment which shall, if considered necessary by Landlord, be installed in
a manner, which may require reinforcement of the Building's structure (at Tenant's cost and expense) to insure satisfactory weight
distribution. All damage done to the Building by reason of a safe or any other article of Tenant's office equipment being on the
Premises shall be repaired at the expense of Tenant. The time, routing, and manner of moving safes or other heavy equipment shall
be subject to Landlord's reasonable prior written approval.

 

(4)       Only persons reasonably
authorized by Landlord shall be permitted to furnish towels, barbering, shoe shining, floor polishing in the Common Areas and other
similar services and concessions to Tenant, and only at hours and under regulations fixed by Landlord.

 

(5)       Tenant shall not at
any time, cause or allow the placement, leaving or discarding of any rubbish, paper, articles or objects of any kind whatsoever
outside the doors of the Premises or in the corridors or passageways of the Building.

 

(6)       Landlord shall have
the right to prohibit any advertising by Tenant which, in Landlord's opinion, tends to impair the reputation of the Building or
its desirability for offices, and, upon written notice from Landlord, Tenant shall refrain from or discontinue such advertising.

 

(7)       Tenant shall not place,
or cause or allow to be placed, any signage, lettering or graphics whatsoever, in or about the Premises except in and at such places
as may be designated by Landlord and consented to by Landlord in writing, prior to the installation of such signage, lettering
or graphics. All signage, lettering, and graphics on corridor doors and walls shall conform to the Building standard prescribed
by Landlord. Any signage, lettering, or graphics located in the Premises that is visible to the public must be approved, in writing,
by Landlord prior to installation thereof. Tenant may display trademarks on interior walls and doors of the Premises.

 

(8)       Canvassing, soliciting
or peddling in the Building is prohibited and Tenant shall cooperate to prevent same.

 

(9)       Landlord shall have
the right to exclude any person from the Building other than during customary business hours for unlawful, lewd behavior, or unreasonable
disturbance, and any person in the Building shall be subject to identification by employees and agents of Landlord. All persons
in or entering the Building shall be required to comply with the security policies of the Building. If Tenant desires any additional
security services for the Premises, Tenant shall have the right (only with the advance written consent of Landlord) to obtain such
additional services at Tenant's sole cost and expense. Tenant shall keep doors to unattended areas locked and shall otherwise exercise
reasonable precautions to protect property in the Building and the Premises from theft, loss or damage.

 

     

     

    

 

(10)       Except for service
providers to Tenant that are involved in the conduct of Tenant’s business, including, but not limited to manufacturing workers,
only workers employed, designated, or reasonably approved by Landlord may be employed for repairs, installations, alterations,
painting, material moving and other similar work that may be done to the Premises.

 

(11)       Tenant shall not do
or allow any cooking or conduct any restaurant, luncheonette, automat or cafeteria for the sale or service of food or beverages
to its employees or to others, nor shall Tenant provide any vending machines in the Common Areas without Landlord's prior written
consent. Tenant may, however, provide, at Tenant's cost and expense, microwave oven(s), refrigerator(s) and coffee machine(s) in
a designated break room/area(s) of the Premises for use by Tenant's employees and invitees.

 

(12)       Except as otherwise
expressly provided in Exhibit I, Tenant shall not bring, or cause or allow to be brought or kept in or on the Premises,
the Building or the Campus, any bleach, inflammable, combustible, corrosive, caustic, odorous, poisonous, toxic or explosive substance
or any substance deemed to be a hazardous or toxic material under any applicable environmental law or regulation.

 

(13)       Tenant shall not mark,
paint, drill into or in any way deface any part of the Building or the Premises. No boring, driving of nails or screws, cutting
or stringing of wires shall be permitted, except with Landlord's prior written consent, and as Landlord may direct; provided, however,
that Tenant shall be permitted to install or hang usual and customary office artwork and dryboards without Landlord's prior written
consent. Tenant shall not install coat hooks, identification plates or anything else on doors nor any resilient tile or similar
floor covering in the Premises except Landlord's reasonable prior written approval. The use of cement or other similar adhesive
material is expressly prohibited.

 

(14)       Tenant shall not place
any additional locks or bolts of any kind on any door in the Building or the Premises or change or alter any lock on any door therein
in any respect without Landlord’s prior reasonable approval. Landlord shall furnish two (2) keys for each lock on exterior
doors to the Premises, and two (2) keys (conventional or card type) for one (1) or more exterior doors to the Building, and shall,
on Tenant's request and at Tenant's expense, provide additional duplicate keys. Tenant shall not make any duplicate keys. All keys
shall be returned to Landlord upon the termination of this Lease, and Tenant shall give to Landlord the explanation of the combination
of all safes, vaults, and combination locks in the Premises. Landlord may at all times keep a pass key to the Premises. All entrance
doors to the Premises shall be left locked when the Premises are not in use.

 

(15)       Tenant shall give reasonably
prompt notice to Landlord in case of its discovery of any theft, unauthorized solicitation or accident in the Premises or in the
Building or of defects therein or in any fixtures or equipment, or of any known emergency in the Building.

 

(16)       Tenant shall place
a water-proof tray under all plants in the Premises and shall be responsible for any damage to the floors, carpets, and/or any
other damage caused by over-watering such plants.

 

(17)       Tenant shall not use
the Premises or allow the Premises to be used for photographic, multilith, multigraph or digital reproductions, except in connection
with its own business and not as a service for others, without Landlord's prior written permission.

 

(18)       Tenant shall not use
or permit any portion of the Premises to be used for any uses other than those specifically granted in Tenant's Lease.

 

(19)       Tenant shall not advertise
for laborers (i.e. those who perform physical labor outdoors) giving the Premises as an address, nor pay such laborers at
a location in the Premises.

 

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(20)       Employees of Landlord
or Landlord's agent(s) shall not perform any work or do anything outside of their regular duties, unless under special instructions
from Landlord or Landlord's agent(s).

 

(21)       Tenant shall not place
a load upon any floor of the Premises which exceeds the load per square foot which such floor was designed to carry and which is
allowed by law, regulation or code business machines and mechanical and electrical equipment belonging to Tenant which cause noise,
vibration, electrical or magnetic interference, or any other nuisance that may be transmitted to the structure or other portions
of the Building or to the Premises to such a degree as to be objectionable to Landlord or which interfere with the use or enjoyment
by other tenants of their Premises or the public portions of the Building, shall be placed and maintained by Tenant, at Tenant's
expense, in settings of cork, rubber, spring type or other vibration eliminators sufficient to eliminate noise or vibration.

 

(22)       Omitted.

 

(23)       No solar screen materials,
awnings, draperies, shutters or other interior or exterior window coverings that are visible from the exterior of the Building
or from the exterior of the Premises within the Building may be installed by Tenant.

 

(24)       Omitted.

 

(25)       No portion of the Premises
or any other part of the Building shall at any time be used or occupied as sleeping or lodging quarters.

 

(26)       For purposes of this
Lease, holidays shall be deemed to mean and include the following: (a) New Year's Day; (b) Memorial Day; (c) Independence Day;
(d) Labor Day; (e) Thanksgiving Day and the Friday following; and (f) Christmas Day. If any such holiday occurs on a weekend, then
the holiday shall be the day such holiday is legally observed.

 

(27)       Tenant shall at all
times keep the Premises neat and orderly.

 

(28)       Tenant shall use no
other method of heating or cooling than that supplied by Landlord or approved by Landlord.

 

(29)       Omitted.

 

(30)       The toilet rooms, urinals,
wash bowls and other plumbing apparatus shall not be used for any purpose other than that for which they were constructed, and
no foreign substance of any kind whatsoever shall be thrown therein. Furthermore, no acid(s), chemical(s) or Hazardous or Toxic
Materials shall be poured or placed into any laboratory sink, drain or other plumbing apparatus.

 

(31)       Tenant shall keep corridor
and lobby doors closed when not in use.

 

(32)       All permitted alterations
and additions to the Premises must conform to applicable building and fire codes. Other than Landlord’s work in delivering
the initial Tenant Upfit, Tenant shall obtain prior approval from applicable building and fire officials and, as contemplated by
Section 7, Landlord with respect to any such modifications and shall deliver "as-built" plans therefor
to the property manager for the Building on completion.

 

(33)       It is the intent of
both Landlord and Tenant that any portion of the Premises visible to the public hold a high quality professional image at all times.
If, at any time during the Term, Landlord or Landlord's agent deems such visible area to hold less than a high quality professional
image, Landlord shall advise Tenant of desired changes to be made to such area to conform to the intent of this paragraph. Within
three business days, Tenant shall cause the desired changes to be made, or present Landlord with a plan for accomplishing such
changes. Tenant shall have such additional time as is reasonably required to implement the plan, not to exceed two months; provided,
however, that if Tenant is not diligently pursuing the plan for accomplishing such changes within 10 business days, or does not
implement the plan within two months, then Landlord may provide draperies or blinds for the glassed area at Tenant's expense, and
Tenant shall keep such draperies or blinds closed at all times.

 

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(34)       Any carpet and wall
coverings located in the Premises that is visible to the public must be consistent in color and style with the carpet and wall
coverings located in the lobby area of the Building and must be reasonably approved by Landlord prior to installation. This rule
shall not apply to any space located on a floor of the Building where Tenant has leased all of the rentable space for that floor.

 

(35)       The Building has been
designated a "non-smoking" building. Tenant, and all persons entering the Building under the express or implied
invitation of Tenant are prohibited from smoking in the common areas both inside and outside of the Building, except in those areas
outside the Building designated as smoking areas by Landlord.

 

(36)       No animals, except
for "service animals" trained to assist disabled persons, shall be brought or kept in or about the Premises or the Building
without Landlord's prior written consent.

 

(37)       Tenant shall not play
or allow the playing or the generation of (i) any music or loud noise in the common areas of the Building without Landlord's prior
written consent and/or (ii), any loud music or loud noise in the Premises, as determined by Landlord in Landlord's sole discretion.

 

(38)       Tenant shall not cause
or allow any odors and/or fumes deemed obnoxious or otherwise unreasonable by Landlord, in Landlord's sole discretion, to permeate
or emanate from the Premises.

 

(39)       Tenant shall not bring,
or cause or allow to be brought, any firearms, ammunition, or weapons of any kind, whether concealed or otherwise, into the Building
at any time.

 

(40)       Landlord reserves the
right to rescind, amend, and add Building Rules, and to waive Building Rules with respect to any tenant or tenants.

 

 

 

 

 

 

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EXHIBIT I

ITEMIZED INVENTORY OF HAZARDOUS
SUBSTANCES

 

	Material Name 	Amount Stored 
	 	 
	Peridox 	12 gallons 
	LpH 	12 gallons 
	70% IPA 	330 gallons 
	Bleach Sodium Hypochlorite 	25 gallons 
	100% Ethanol 	32 Liters 
	100% IPA 	20 Liters 
	CO2 	14 @ 50 pound cylinders 
	LN2 	6 @ 240 liter dewars 
	Compressed Air 	2 @ 312 cubic feet 
	Formaldehyde Solution 	3 Liters 
	Hydrochloric Acid 0.1 N 	1 liter
	Sodium Hydroxide Solution 1 OM 	1 liter
	Gram Decolorizer 	1 liter
	Methanol, CHROMASOLV for HPLC .::99.9%	200 ml 

 

 

 

 

 

 

 

 

     

     

    

 

EXHIBIT J

RADIOACTIVE MATERIALS/RADIOACTIVE
EQUIPMENT REQUIREMENTS

 

Conditions of Use: Ionizing Radiation Producing Equipment and Radioactive Materials

 

Tenant shall be responsible for performing all actions associated
with licensing or registration and for all activities associated with compliance with the rules and regulations in the "North
Carolina Regulations for Protection Against Radiation" ("15A NCAC 11"). License applications or
equipment registration activities are strictly between Tenant and the State of North Carolina Radiation Protection Section. Landlord
in no way serves as an agent for Tenant in this regard nor shall Landlord be responsible for furnishing any special Building features
or services to support these activities.

 

Tenant shall be responsible for providing the NCSU Radiation Safety
Division with a copy of its current licenses/registrations and any other requested documentation. The NCSU Radiation Safety Division
may visit the Premises or inspect the activities of Tenant with respect to these licenses and/or registered activities. Upon termination
of this Lease, Tenant is solely responsible for removing or transferring all such registered or licensed devices or material at
Tenant's sole cost and expense.

 

Tenant shall be responsible for developing emergency plans and notification procedures
as required by federal, state, or municipal agencies and for supplying copies of these approved documents to Landlord.

 

	I.	Ionizing Radiation Producing Equipment

 

Tenant shall be responsible for ensuring that Ionizing Radiation
Producing Equipment, such as x-ray units, electron microscopes, gas chromatographs with electron capture devices, and particle
accelerators, etc., are procured, registered or licensed, and used in full compliance with the rules and regulations published
in the most current version of 15A NCAC 11, and the conditions of use as listed below.

 

	II.	Radioactive Materials

 

		(A)	Licensed Radioactive Materials. Tenant shall be responsible for ensuring that Licensed Radioactive Materials are procured and
used in full compliance with the "General Licensing" provisions of the U.S. Nuclear Regulatory Commission as adopted
by the State of North Carolina in 15A NCAC 11. Tenant shall comply fully with all aspects of the General License requirements,
and Tenant expressly acknowledges and agrees that all licenses for the use of radioactive materials shall be reviewed and approved
by the NCSU Radiation Safety Division prior to submittal to the State of North Carolina Radiation Protection Section.

 

		(B)	Radioactive materials covered as either source material exempt (15A NCAC 11.0302) or as exempt quantities other than source
material (15A NCAC 11.0304) or under a specific license (including License of Broad Scope). Tenant shall be responsible for ensuring
that radioactive material in this category is procured, used, transferred, and disposed of in full compliance with the rules and
regulations published in the most current version of the 15A NCAC 11 and that all licenses for use of radioactive material or registration
of radiation producing devices are reviewed by the NCSU Radiation Safety Division prior to submittal to North Carolina Radiation
Protection Section. Landlord also specifically requires that:

 

		(i)	Tenant's use will not result in any disposal of radioactive materials to the sanitary sewer or to the atmosphere in excess
of permit limits (under EPA, NRC, and NC DENR). Landlord requires that this be a condition of the license application. Other Landlord
requirements may apply.

 

		(ii)	Tenant shall dispose of all radioactive waste in accordance with all license conditions, and in accordance with all applicable
NCSU requirements. On-site storage of radioactive waste generated by Tenant shall be limited, pursuant to license conditions and
subject to approval by NCSU. The disposal methods for this material must be documented in the radiation safety program and license
application.

 

     

     

    

 

		(iii)	Tenant shall be responsible for ensuring that its use is consistent with any other permits and/or agreements between NCSU,
the State of North Carolina and/or the United States Environmental Protection Agency related to protection of the environment.

 

		(iv)	Landlord will not consider this Lease terminated or expired until Tenant demonstrates, or, at Landlord's option, Tenant obtains,
at Tenant's sole cost and expense, an independent, third-party, duly licensed, expert (i.e., having at least five (5) years'
experience, hereinafter, a "qualified expert") certification, that all radioactive material has been removed from the
Premises and that any remaining radioactive contamination is not in excess of acceptable limits (15A NCAC 11), including from all
surfaces and from within hoods and sinks and associated conduits. Landlord also reserves the right to hire, at Tenant's sole cost
and expense, a second qualified expert to take any measurements as such qualified expert may deem necessary with regard to determining
whether all radioactive material has been removed and whether any remaining contamination is in excess of acceptable limits, which
may include the review of previous qualified expert certifications.

 

	III	Non-ionizing Radiation Producing Equipment

 

Non-ionizing radiation producing equipment, including lasers and
microwave sources, shall comply with North Carolina regulations and the appropriate American National Standards Institute standards,
e.g., ANSI Z136 for lasers. Tenant is responsible for providing the NCSU Radiation Safety Division (or other appropriate
entity(ies)) with a current written inventory of all such equipment. The Radiation Safety Division may require copies of pertinent
documents demonstrating compliance with appropriate regulations. Tenant shall supply copies thereof to Landlord.

 

 

 

 

 

 

 

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EXHIBIT K

LEASE
MEMORANDUM

 

 

 

 

Prepared By & Hold For: Burns, Day & Presnell, PA (JMD) - Box 35

 

NORTH CAROLINA

	WAKE COUNTY	MEMORANDUM OF LEASE

 

Pursuant to that unrecorded Lease Agreement dated January 17, 2017
(the "Lease"), Keystone-Centennial II, LLC, a North Carolina limited liability company, as Landlord,
in consideration of the rents and other considerations specified in the Lease, has leased to Argos Therapeutics, Inc., a
Delaware corporation, as Tenant, certain space in that building located at 1010 Main Campus Drive in Raleigh, North Carolina, (the
"Premises"). The term of the Lease commences on the date of this instrument and ends on or about August
15, 2027; provided that Tenant also has two options to extend the Lease, for an additional five years each.

 

Unless otherwise required by then beneficiary (which shall be evidenced
in an agreement signed by that beneficiary), Tenant's rights under the Lease will be subordinate to the lien of that beneficiary's
deed of trust which encumbers the Premises (the "Deed of Trust") whether the Deed of Trust is currently
a lien on the Premises or subsequently becomes a lien on the Premises. No further agreements or documents shall be required to
render the Lease and Tenant's rights subordinate to the Deed of Trust.

 

This Memorandum is not a complete summary of the Lease Agreement
and is subject to all the conditions, terms, and provisions of that document, which is incorporated into this instrument by this
reference. Provisions in the Memorandum shall not be used in interpreting the Lease. In the event of conflict between the Memorandum
and the Lease, the Lease shall control.

 

Upon a valid termination of the Lease, for whatever reason, Landlord
shall be entitled to record a notice of that termination on its own signature.

 

[Signatures on Next Two Pages]

 

     

     

    

 

IN WITNESS WHEREOF, the undersigned have executed, sealed,
and delivered this instrument as of the date first above written.

 

 

 

 

 

 

 

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EXHIBIT L

GENERATOR

 

Subject to the terms of this Exhibit and the provisions of Section
7 not otherwise in conflict with this Exhibit, during the Term Tenant shall have the right to install and operate a generator
(the "Generator") as a backup power source to serve its Premises. Tenant’s rights to install and
operate the Generator are expressly subject to the following conditions:

 

(a) Tenant shall install the Generator in the Common Area at the
location reflected on the schematic attached to this Exhibit and otherwise in accordance with the plans and specs reasonably approved
by the Landlord. As a condition of its approval, Landlord may, in its discretion, require Tenant, at Tenant’s sole expense,
to adequately screen the Generator from view (the design of the screening to be subject to Landlord’s reasonable prior written
approval).

 

(b) Tenant, at its expense, shall be solely responsible for: (i)
the installation, operation, and maintenance of the Generator and any required screening; (ii) obtaining and maintaining all required
operating permits and governmental approvals; and (iii) otherwise complying with all applicable legal requirements relating to
the Generator. Tenant shall also promptly repair any damage to the Building, Common Areas, and/or Premises caused by the installation,
operation, or maintenance of the Generator.

 

(c) The Generator shall remain Tenant’s property throughout
the Term and Tenant shall maintain full replacement value insurance to protect its interest. Tenant shall also be responsible for
any additional insurance and/or increase in insurance premiums incurred by Landlord as a result of the installation of the Generator.

 

(d) Tenant’s access to the Generator shall be subject to such
reasonable conditions imposed by Landlord.

 

(e) Tenant’s rights under this Exhibit shall not unreasonably
interfere with the other tenants' use of their respective premises in the Building.

 

(f) Landlord, at its expense (except where necessitated by any applicable
legal requirement or governmental authority, where it will be Tenant’s expense), shall have the right, on not less than five
days' prior written notice (except in the event of an emergency, in which event no notice shall be required) to relocate the Generator,
provided that Landlord must provide backup power during such relocation if not being done pursuant to a legal requirement or governmental
authority. Tenant shall cooperate with Landlord in all reasonable respects relating to any such relocation.

 

(g) Upon termination of this Lease, the Generator shall remain with
the Premises and become Landlord's personal property.

 

(h) The rights granted under this Exhibit are not separately assignable;
but may only be assigned in connection with a permitted assignment of this Lease.

 

 

     

     

    

 

EXHIBIT M

ELECTRIC/HVAC SERVICES - COST ALLOCATIONS

 

The Building is a LEED-certified building and includes a building
management system ("BMS") which separately monitors usage for the electrical system and the HVAC system
serving the Building (the "Monitored Services"). The Monitored Services include: (a) natural gas, electrical
service, and chilled water service used to provide conditioned air (collectively, the "HVAC Services");
and (b) electrical service for lighting and other office/lab purposes (e.g., phones, copiers, computers, lab equipment, and the
like, collectively, the "Lighting/Equipment Electrical Services"). The BMS will effectively measure usage
of the Monitored Services for the common areas of the Building and all of the rentable space in the Building (the "Rentable
Space") through the use of a combination of sub-meters and monitors which are located in the HVAC ducts and units
throughout the Rentable Space. (Note that a given area monitored by a single monitor may not be limited to one tenant's space;
i.e., the individually monitored area may include all or portions of multiple tenant spaces.) The usage data generated by the
BMS will be used to allocate the costs for the Monitored Services (the "Allocable Costs") to the Rentable
Space and the Common Areas.

 

Based on the design of the Premises, Tenant's share of the Allocable
Costs (as defined below) shall include costs for the following:

 

		·	100% of the chilled water service and electrical service portions of the HVAC Services usage allocated by the BMS to that roof-top
HVAC unit(s) only serving the Phase III Space. (Each of these HVAC units shall be separately monitored by the BMS.)

 

		·	100% of the natural gas service portion of the HVAC Services usage allocated by the BMS to that roof-top HVAC unit(s) only
serving the Phase III Space. (This portion of the HVAC Services shall be separately metered.) 

 

		·	100% of the Lighting/Equipment Electrical Services usage allocated by the BMS to each Phase of the Premises. (The Lighting/Equipment
Electrical Services for each Phase of the Premises shall be separately metered.)

 

		·	Tenant's allocable share of the HVAC s Services usage allocated by the BMS to the HVAC unit(s) serving the space which includes
the Phase I Space, the Phase II Space, and other Rentable Space. (Each discrete portion of this shared area (e.g. the Phase
II Space) shall be separately monitored by the BMS and the usage for this HVAC unit(s) allocated between the tenants of the Shared
HVAC Space based on those tenants' relative usage.)

 

The natural gas service, the electrical service, and the chilled
water service included in the Monitored Services will be in Landlord's name and there will be a single, master-meter for the entire
Building for each of these utility services. Landlord will receive a monthly bill from each utility service provider (i.e., NCSU
and PSNC) for each master-meter (each a "Utility Bill"). Unless separately metered, the total amount due
reflected on each Utility Bill shall be allocated, on a pro rata basis, to the Rentable Space based on the usage data generated
by the BMS, with the balance of the usage reflected in the BMS being allocated to the Common Areas. Each calendar month, Landlord
will send an electronic statement (the "Utility Statement") to Tenant showing the Allocable Costs due from
Tenant. Each Utility Statement will include electronic copies: (i) each applicable Utility Bill; (ii) the report generated by the
BMS for the usage reflected in each of those Utility Bills; and (iii) Landlord's calculations used in calculating the Tenant's
Allocable Costs. Tenant shall pay the Allocable Costs due from it to Landlord within 20 days after Tenant's receipt of each Utility
Statement.

 

For avoidance of doubt, the Utility Statements shall not include:

 

(a) Any of the costs charged by a Tenant's Provider, such costs to
be Tenant's sole responsibility.

 

(b) That portion of the Allocable Costs allocable to the Common Areas
or any charges for water or sewage services, all of which shall be included in "Expenses" and charged to Tenant
pursuant to Section 5.3.

 

     

     

    

 

EXHIBIT N

TENANT’S LIST OF PERSONAL
PROPERTY

 

		·	All manufacturing equipment

		·	All quality control equipment located within the Phase II Space

		·	All furniture

		·	All office equipment

		·	All other items that are not attached to the Premises, including biosafety cabinets

		·	All equipment that incorporates Tenant’s intellectual property

		·	All items identified to be removed by Tenant in the Approved Plans & Specs, Change Orders, and/or Alteration approvalsExhibit 10.44

 

 

Confidential Materials omitted and filed separately with the

Securities and Exchange Commission .Double asterisks denote omissions.

OMB Approval 2700-0042 

	 	1.
    CONTRACT ID CODE	PAGE
    OF PAGES
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT	 	1	6
	2.  AMENDMENT/MODIFICATION
    NO.	3.  EFFECTIVE
    DATE	4.  REQUISITION/PURCHASE
    REQ. NO.	5.  PROJECT
    NO. (If applicable)
	   Thirteen (13)	See Block 16C.	N/A	N/A
	6.  ISSUED BY	CODE      	  	7.  ADMINISTERED BY (If other than Item 6)	CODE	N/A
	 	 	 	 	 	 	 	 	 	 
	Office of Acquisitions, DEA	TIB, BSP, DAIDS	 	 	 
	National Institute of Allergy and Infectious Diseases	 	 	 	 	 	 
	National Institutes of Health, DHHS	 	 	 	 	 	 
	5601 Fishers Lane, Room 3D10, MSC 9821	 	 	 	 	 	 
	Bethesda, MD  20892-9821	 	 	 	 	 	 

	8.  NAME AND ADDRESS OF CONTRACTOR
    (No. Street, County, State and ZIP: Code)	[  ]	9A.  AMENDMENT OF SOLICITATION NO.
	 	 	 
	Argos Therapeutics, Inc.                                               VIN # 1109171	 	9B.  DATED (SEE ITEM 11)
	4233 Technology Drive 	 	 
	Durham, NC 27704	X	10A.  MODIFICATION OF CONTRACT/ORDER NO.
	 	 	HHSN266200600019C
	 	 	10B.  DATED (SEE ITEM 13)
	CODE 	  FACILITY
    CODE 	 	September 30, 2006

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

 

☐The above numbered solicitation
is amended as set forth in Item 14. The hour and date specified for receipt of Offers☐is extended, ☐is
not extended.

Offers must acknowledge receipt of
this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:  

(a) By completing Items 8 and 15, and returning one (1) copy of the amendment; (b) By acknowledging receipt of this amendment
on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and
amendment numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE
HOUR AND DATA SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already
submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation
and this amendment, and is received prior to the opening hour and data specified.

	12.  ACCOUNTING AND APPROPRIATION
    DATA (If required)
	 	 
	N/A
	 	 
	13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
	IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.
	[  ]	A.
    THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority)   THE
    CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.
	 	 
	 	B.
    THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such
    as changes in paying office, appropriation date, etc.) SET 
	 	C.
    THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
	X	FAR 1.602-1
	 	 
	 	D.
    OTHER (Specify type of modification and authority)
	 	 
	E.  IMPORTANT:  Contractor ☐
     is not, ☒  is required to sign this document and return      1    copy
    to the issuing office.
	14.  DESCRIPTION OF AMENDMENT/MODIFICATION
    (Organized by UCF section headings, including solicitation/contract subject matter where
    feasible.)
	PURPOSE:  To:  (1)
    extend the contract for a period of 24-months, from July 31, 2016 to July 31, 2018, at no additional cost to the Government;
    and (2) revise Articles B.2., B.4., B.5., F.3., G.2., G.3., H.6., H.7., H.8.; (3) delete Article H.23.; and (4) revise Section
    K, as reflected on pages 1-6.

 

 

 

 

	TOTAL OBLIGATED AMOUNT:  $39,825,381.91 (Unchanged)        TOTAL CONTRACT AMOUNT: $39,825,381.91 (Unchanged)
	CONTRACT FUNDED THROUGH:  July 31, 2018 (CHANGED)         CONTRACT COMPLETION DATE:  July 31, 2018 (CHANGED)
	 
	Except as provided herein, all terms and
    conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.
	15A.  NAME AND TITLE OF SIGNER   (Type
    or print)	16A.  NAME
    AND TITLE OF CONTRACTING OFFICER   (Type or print)
	Jeff Abbey, President & CEO	 	   Robert Corno, Contracting Officer
	 	 	   Office of Acquisitions, DEA, NIAID, NIH, DHHS
	15B.  CONTRACTOR/OFFEROR	15C.  DATE
    SIGNED	16B.  UNITED STATES OF AMERICA	16C.  DATE
    SIGNED
	 	6-29-2016	 	 
	_/s/
    Jeff Abbey______________________	 	BY   /s/
    Robert Corno___________________	6/30/2016
	(Signature
    of person authorized to sign)	 	(Signature
    of Contracting Officer)	 

 

	NSN 7540-01-152-8070	30-105	STANDARD FORM 30 (REV. 10-83)
	PREVIOUS EDITION UNUSABLE	Computer Generated	Prescribed by GSA
	 	 	FAR (48 CFR) 53.243

 

     

     

    

 

	Argos Therapeutics, Inc.	 	 
	Contract No. HHSN266200600019C	 SPECIAL PROVISIONS	 Page 2 of 6
	Modification No. 13

	 	 

 

 

BEGINNING WITH THE EFFECTIVE DATE OF THIS MODIFICATION, THE GOVERNMENT AND THE CONTRACTOR
MUTUALLY AGREE AS FOLLOWS:

 

B.2. ESTIMATED COST – OPTION, paragraph d., is hereby revised to
reflect the revised period of performance under Option 1, which shall read as follows:

 

		d.	If the Government exercises its options pursuant to the OPTION PROVISION Article in SECTION H of this contract, the Government's
total estimated contract amount, represented by the sum of the estimated cost plus fixed fee, will be increased as follows:

 

	 	Period of Performance	Estimated Cost	Fixed Fee	Estimated CPFF
	Base	09/30/2006-06/30/2010	[**]	[**]	[**]
	Option 1 – Autologous Vaccine and Clinical Trial	07/01/2010-07/31/2018	[**]	[**]	[**]
	Total Base Plus Option 1	 	$38,430,282.91	$1,395,099	$39,825,381.91

 

ARTICLE B.4. PROVISIONS APPLICABLE TO DIRECT COSTS, paragraph b., is revised
to reflect the revised period of performance under Option 1, which shall read as follows:

 

b. Travel Costs

 

1.      Domestic Travel

 

Total expenditures for domestic travel (transportation, lodging, subsistence, and incidental expenses) incurred in direct performance
of this contract shall not exceed the total amount $[**] during the Base Period (9/30/2006 – 6/30/2010), without the prior
written approval of the Contracting Officer.

 

If the Government exercises its Options pursuant to the OPTION PROVISION Article
in SECTION H of this contract, the Government’s total estimated amount for domestic travel shall not exceed the amounts indicated
below:

 

	 	Period of Performance	Total Cost Not to Exceed
	Option 1 	07/01/2010-07/31/2018	[**]
	Total Base Plus Option 1	 	[**]

 

     

     

    

 

	Argos Therapeutics, Inc.	 	 
	Contract No. HHSN266200600019C	 SPECIAL PROVISIONS	 Page 3  of
    6
	Modification No. 13

	 	 

 

 

ARTICLE B.5. ADVANCE UNDERSTANDINGS, paragraph c. and paragraph i., item
2., are hereby revised to reflect the revised period of performance under Option 1, which shall read as follows:

 

		c.	Consultants

 

(1) Consultant fees to be paid to the members of the External
Advisory Board are authorized as indicated below:

 

	Option	Period of Performance	Total Cost, Excluding Travel, Not to Exceed
	Base	09/30/2006-06/30/2010	[**]
	Option 1	07/01/2010-07/31/2018	[**]
	Total Base Plus Option	 	[**]

 

(2) Consultant fees to be paid to [**] are authorized as indicated below:

 

	Option	Period of Performance	Total Cost, Excluding Travel, Not to Exceed
	Base	09/30/2006-06/30/2010	[**]
	Option 1	07/01/2010-07/31/2018	[**]
	Total Base Plus Option	 	[**]

 

 

(3) Consultant fees to be paid to [**] Medical Services
are authorized as indicated below:

 

	Option	Period of Performance	Total Cost, Excluding Travel, Not to Exceed
	Base	09/30/2006-06/30/2010	[**]
	Option 1	07/01/2010-07/31/2018	[**]
	Total Base Plus Option	 	[**]

 

		i.	Cost Sharing

 

2. The Government shall provide monies in amounts not to exceed those listed under Government’s
Share, during the Base and Option 1, in the table below. The Contractor’s share is estimated at the amount(s) listed under
Contractor’s Share, during the Base and Option 1, in the table below. The table below provides a breakout of cost sharing
under the contract, during the Base and Option 1, as follows:

 

	 	Period of 

Performance	
         Total Cost
	
        Government’s

        Share
	Contractor’s Share
	Base	09/30/2006-06/30/2010	[**]	[**]	[**]
	Option 1 – Autologous Vaccine and Clinical Trial	07/01/2010-03/31/2018	[**]	[**]	[**]
	Total Base Plus Option	 	
         

        $40,334,480.91
	$39,825,381.91	
         $509,099.00

 

     

     

    

 

	Argos Therapeutics, Inc.	 	 
	Contract No. HHSN266200600019C	 SPECIAL PROVISIONS	 Page 4   of
    6
	Modification No. 13

	 	 

 

 

ARTICLE F.3. OPTION PERIODS, is hereby revised to reflect the revised period
of performance under Option 1, and shall read as follows:

 

If the Government exercises its options pursuant to the OPTIONS
PROVISION Article in SECTION H of this contract, the completion date of the contract will be extended as follows:

 

	Option	Period of Performance
	Base	09/30/2006-06/30/2010
	Option 1	07/01/2010-07/31/2018

 

ARTICLE G.2. KEY PERSONNEL, HHSAR 352.242-70 (January 2006), is hereby
revised to include the updated HHSAR reference/language, and shall read as follows:

 

ARTICLE G.2. KEY PERSONNEL, HHSAR 352.237-75 (December 2015)

 

The key personnel specified in this contract are considered to be essential to work performance.
At least 30 days prior to the contractor voluntarily diverting any of the specified individuals to other programs or contracts
the Contractor shall notify the Contracting Officer and shall submit a justification for the diversion or replacement and a request
to replace the individual. The request must identify the proposed replacement and provide an explanation of how the replacement's
skills, experience, and credentials meet or exceed the requirements of the contract (including, when applicable, Human Subjects
Testing requirements). If the employee of the contractor is terminated for cause or separates from the contractor voluntarily with
less than thirty days notice, the Contractor shall provide the maximum notice practicable under the circumstances. The Contractor
shall not divert, replace, or announce any such change to key personnel without the written consent of the Contracting Officer.
The contract will be modified to add or delete key personnel as necessary to reflect the agreement of the parties.

 

(End of Clause)

 

The following individuals are considered to be essential to the work being performed
hereunder:

 

	Name	Title
	[**]	Principal Investigator

 

ARTICLE G.3. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL
REPORT, paragraph g., is hereby revised to reflect the revised period of performance under Option 1, which shall read as
follows:

 

		g.	Payments shall be made from the following PRISM/NBS Line Item Numbers. The table below sets forth the specific line item numbers
to be designated on invoices.

 

	
         

        Line Item No.
	
         

        Option Description
	
         

        Line Item Period of Performance
	
         

        Funded Amount

	8.	Option 1	July 1, 2010 – July 31, 2018	$5,415,284
	9.	Option 1	July 1, 2010 – July 31, 2018	$505,050

NOTE: When additional funding is provided by exercise of an Option, new line item numbers, including the line item descriptions,
line item periods of performance, and funded amounts will be added to the above table in a subsequent modification.

 

     

     

    

 

	Argos Therapeutics, Inc.	 	 
	Contract No. HHSN266200600019C	 SPECIAL PROVISIONS	 Page 5    of
    6
	Modification No. 13

	 	 

 

 

ARTICLE H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH and ARTICLE H.23.
RESTRICTION ON ABORTIONS, are hereby deleted in their entirety and replaced with the following:

 

ARTICLE H.6. CONTINUED BAN ON FUNDING ABORTION AND CONTINUED BAN ON FUNDING OF
HUMAN EMBRYO RESEARCH, HHSAR 352.270-13 (December 2015)

 

	 	a. 	The Contractor shall not use any funds obligated under this contract for any abortion.
	 	b. 	The Contractor shall not use any funds obligated under this contract for the following:
	 	 	1.	The creation of a human embryo or embryos for research purposes; or
	 	 	2.	Research in which a human embryo or embryos are destroyed, discarded, or knowingly subjected to risk of injury of death greater than that allowed for research on fetuses in utero under 45 CFR part 46 and Section 498(b) of the Public Health Service Act (42 U.S.C. 289g(b)).
	 	c.	The term “human embryo or embryos'' includes any organism, not protected as a human subject under 45 CFR part 46 as of the date of the enactment of this Act, that is derived by fertilization, parthenogenesis, cloning, or any other means from one or more human gametes of human diploid cells.
	 	d. 	The Contractor shall not use any Federal funds for the cloning of human beings.

 

 
(End of clause)

 

ARTICLE H.7. NEEDLE DISTRIBUTION, is hereby deleted in its entirety and
replaced with the following:

 

ARTICLE H.7. NEEDLE EXCHANGE, HHSAR 352.270-12 (December 2015)

The Contractor shall not use any funds obligated under this contract to
carry out any program of distributing sterile needles or syringes for the hypodermic injection of any illegal drug.

 

(End of clause)

 

 

ARTICLE H.8. PRIVACY ACT, is hereby revised to include the updated HHSAR
reference/language, and shall read as follows:

 

ARTICLE H.8. PRIVACY ACT, HHSAR 352.224-70 (December 2015)

 

This contract requires the Contractor to perform one or more of the following: (a) Design;
(b) develop; or (c) operate a Federal agency system of records to accomplish an agency function in accordance with the Privacy
Act of 1974 (Act) (5 U.S.C. 552a(m)(1)) and applicable agency regulations.  The term "system of records" means a
group of any records under the control of any agency from which information is retrieved by the name of the individual or by some
identifying number, symbol, or other identifying particular assigned to the individual.  Violations of the Act by the Contractor
and/or its employees may result in the imposition of criminal penalties (5 U.S.C. 552a(i)).  The Contractor shall ensure that
each of its employees knows the prescribed rules of conduct in CFR 45 part 5b and that each employee is aware that he/she is subject
to criminal penalties for violation of the Act to the same extent as Department of Health and Human Services employees.  These
provisions also apply to all subcontracts the Contractor awards under this contract which require the design, development or operation
of the designated system(s) of records [5 U.S.C. 552a(m)(1)].  The contract work statement: (a) identifies the system(s) of
records and the design, development, or operation work the Contractor is to perform; and (b) specifies the disposition to be made
of such records upon completion of contract performance.

 

(End of clause)

 

     

     

    

	Argos Therapeutics, Inc.	 	 
	Contract No. HHSN266200600019C	 SPECIAL PROVISIONS	 Page 6     of
    6
	Modification No. 13

	 	 

 

 

45 CFR Part 5b contains additional information which includes
the rules of conduct and other Privacy Act requirements and can be found at: http://www.access.gpo.gov/nara/cfr/waisidx_06/45cfr5b_06.html.

 

The Privacy Act System of Records applicable to this project
is Number 09-25-0200. This document is available at: http://oma.od.nih.gov/public/MS/privacy/PAfiles/read02systems.htm.

 

 

SECTION K – REPRESENTATIONS & CERTIFICATIONS, item 1., is hereby
revised to incorporate the latest FAR Clause reference and language, and to read as follows:

 

FAR Clause 52.204-19 Incorporation by Reference of Representations and Certifications
(December 2014).

 

The Contractor's representations and certifications, including those completed electronically
via the System for Award Management (SAM), are incorporated by reference into the contract.

 

(End of clause)

 

 

All other terms and conditions
to the contract remain unchanged.

 

END OF MODIFICATION NO. 13,
CONTRACT NO. HHSN266200600019C

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