Document:

<PAGE>

                                                                     Exhibit 4.3

      Agreement to Extend "First Amendment to Boston Life Sciences, Inc.
               Warrants for Purchase of Shares of Common Stock"

This agreement is meant to extend the previous "First Amendment" signed on May
27, 2001 by Mr. Yves Martignier, Pictet Global Sector Fund-Biotech, which
extended the "Reset" of Pictet's Boston Life Sciences, Inc. Warrants from June
1, 2001 to June 15, 2001.

The extension granted hereby will be June 25, 2001.  Exactly the same provisions
of the previous amendment shall apply to this extension and no other changes of
any kind shall apply to the provision of the Warrants which shall remain
unmodified and of full force and effect as originally set forth.

Accepted and Agreed

Pictet Global Sector Fund-Biotech       Boston Life Sciences, Inc.

/s/ Yves Martignier                     /s/ David Hillson
---------------------------------       ---------------------------------
Yves Martignier, Director               David Hillson, President &
                                        Chief Executive Officer

Date: June 13, 2001                     Date: June 13, 2001
      ---------------------------             ---------------------------<PAGE>

                                                                     Exhibit 4.4

                              SECOND AMENDMENT TO
                          BOSTON LIFE SCIENCES, INC.
              WARRANTS FOR THE PURCHASE OF SHARES OF COMMON STOCK
                         NOS. BLSI - J-146 AND - J-147

     SECOND AMENDMENT TO WARRANTS (the "Second Amendment") made and entered into
as of June 25, 2001, by and among Boston Life Sciences, Inc., a Delaware
corporation (the "Company"), and Pictet Global Sector-Fund Biotech (the
"Holder").

     REFERENCE is hereby made to the Boston Life Sciences, Inc. Warrant for the
Purchase of Shares of Common Stock Nos. BLSI - J-146 and - J-147 issued pursuant
to that certain Purchase Agreement among the Company and the Holder dated as of
May 26, 2000, as amended by the First Amendment thereto among the Company and
the Holder dated as of May 27, 2001 (the "Warrants") and further amended by the
"Agreement to Extend the First Amendment", dated June 13, 2001.

     WHEREAS, the Holder and the Company desire to amend certain provisions of
each of the Warrants as set forth herein.

     NOW, THEREFORE, in consideration of the mutual covenants and agreements
hereinafter set forth, the parties to this Second Amendment agree as follows:

     1.   Amendment to Warrants.
          ---------------------

     (a)  The second sentence of the introductory paragraph of each of the
Warrants (which sentence begins "If the weighted average sales price per share")
is hereby deleted and replaced in its entirety with the following:

          "To the extent this warrant has not been exercised prior to June 2,
     2002, the exercise price of the warrant will be adjusted effective as of
     June 30, 2002 to the lower of (x) the weighted average sales price per
                          --------
     share of common stock of the company (as reported by Bloomberg Financial
     Services) for the 20 trading days ending on June 1, 2001 and (y) the
     greater of (i) the weighted average sales price per share of common stock
     of the company (as reported by Bloomberg Financial Services) for the 20
     trading days ending on June 30, 2002 and (ii) $3.00 (as appropriately
     adjusted to reflect any stock splits, stock dividends, reorganizations,
     consolidations and similar changes) (such lower price, the "Reset Price")."

     (b)  The following sentence shall be inserted at the end of the first
sentence of Section 3(d) of each of the Warrants (immediately following the
words "deliverable upon exercise of this Warrant"):

          "; provided, however, that with respect to any such reorganization,
             --------  -------
     reclassification, consolidation, merger, statutory exchange, sale or
     conveyance occurring prior to June 30, 2002, the exercise price of this
     warrant shall be deemed for purposes of this Section 3(d) to be $3.00 per
     share (as appropriately adjusted to reflect any stock splits, stock
     dividends, reorganizations, consolidations and similar changes)."
<PAGE>

     2.   Issuance of Additional Warrants. As of the date hereof, the Company
          -------------------------------
shall execute and deliver 160,000 additional, new warrants to the Holder which
warrants shall also include the "anti-dilution" provision (for an aggregate
total of up to 400,000 additional warrants) as set forth in the warrants
attached as Exhibit A hereto (the "Warrant").
            ---------

     3.   Parties in Interest. All the terms and provisions of this Second
          -------------------
Amendment shall be binding upon and inure to the benefit of and be enforceable
by the respective successors and permitted assigns of the parties hereto, and,
in particular, with respect to the Warrants shall inure to the benefit of and be
enforceable by any proper holder of the Warrants, or its permitted assigns and
with respect to the Note shall inure to the benefit of and be enforceable by any
proper holder of the Note. This Second Amendment shall be treated for all
purposes as having been incorporated into and become a part of each of the
Warrants and any party furnishing a copy of a Warrant to any person shall
furnish a copy of this Second Amendment therewith.

     4.   Headings; Governing Law.  Sections 10 and 11 of the Warrants are
          -----------------------
incorporated herein by reference and shall govern this Second Amendment in the
same manner as if set forth in its entirety herein.

     5.   Counterparts. This Second Amendment may be executed concurrently in
          ------------
two or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument.

     6.   No Other Change. Except to the extent specifically amended hereby, the
          ---------------
provisions of the Warrants shall remain unmodified and the Warrants as amended
hereby are hereby confirmed as being in full force and effect.
<PAGE>

     IN WITNESS WHEREOF, the Company and the Holder have executed this Second
Amendment as of the date and year first above written.

BOSTON LIFE SCIENCES, INC.

By: /s/ S. David Hillson
-----------------------------------
Name:  S. David Hillson
Title:  Chairman, President and
Chief Executive Officer

PICTET GLOBAL SECTOR FUND-BIOTECH

By: /s/ Yves Martignier
-----------------------------------
Name:  Yves Martignier
Title: Director<PAGE>

                                                                     Exhibit 4.5

THESE SECURITIES AND THE SECURITIES ISSUABLE UPON EXERCISE OF THESE SECURITIES
HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"ACT"), AND THEY MAY NOT BE OFFERED, SOLD, PLEDGED, HYPOTHECATED, ASSIGNED OR
TRANSFERRED EXCEPT (i) PURSUANT TO A REGISTRATION STATEMENT UNDER THE ACT WHICH
HAS BECOME EFFECTIVE AND IS CURRENT WITH RESPECT TO THESE SECURITIES, OR (ii)
PURSUANT TO A SPECIFIC EXEMPTION FROM REGISTRATION UNDER THE ACT BUT ONLY UPON A
HOLDER HEREOF FIRST HAVING OBTAINED THE WRITTEN OPINION OF COUNSEL TO THE
COMPANY, OR OTHER COUNSEL REASONABLY ACCEPTABLE TO THE COMPANY, THAT THE
PROPOSED DISPOSITION IS CONSISTENT WITH ALL APPLICABLE PROVISIONS OF THE ACT AS
WELL AS ANY APPLICABLE "BLUE SKY" OR SIMILAR STATE SECURITIES LAW.

                          BOSTON LIFE SCIENCES, INC.

                    Warrant for the Purchase of Shares of
                    -------------------------------------
                                 Common Stock
                                 ------------

No.  BLSI  -  J-155                                               160,000 Shares

FOR VALUE RECEIVED, BOSTON LIFE SCIENCES, INC., A Delaware corporation (the
"Company"), hereby certifies that Pictet Global Sector Fund-Biotech ("Pictet")
or its permitted assigns, is entitled to purchase from the Company, at any time
or from time to time commencing on June 25, 2001 (the "Initial Exercise Date")
and prior to 5:00 P. M., New York City time, on June 25, 2006 (the "Termination
Date"), 160,000 fully paid and non-assessable shares of the Common Stock, $.01
par value per share, of the Company for an aggregate purchase price of  $544,000
computed on the basis of $3.40 (equal to closing market price on date of
issuance plus $.01) per share.  (Hereinafter, (i) said Common Stock, together
with any other equity securities which may be issued by the Company with respect
thereto or in substitution therefor, is referred to as the "Common Stock", (ii)
the shares of the Common Stock purchasable hereunder or under any other Warrant
(as hereinafter defined) are referred to as the "Warrant Shares", (iii) the
aggregate purchase price payable for the Warrant Shares hereunder is referred to
as the "Aggregate Warrant Price", (iv) the price payable for each of the Warrant
Shares hereunder is referred to as the "Per Share Warrant Price", (v) this
Warrant, all similar Warrants issued on the date hereof and all warrants
hereafter issued in exchange or substitution for this Warrant or such similar
Warrants are referred to as the "Warrants" and (vi) the holder of this Warrant
is referred to as the "Holder" and the holder of this Warrant and all other
Warrants or Warrant Shares issued upon the exercise of any Warrant are referred
to as the "Holders").  The Per Share Warrant Price and the number of Warrant
Shares purchasable on exercise of this Warrant shall be subject to adjustment as
hereinafter provided.
<PAGE>

     1.   Exercise of Warrant
          -------------------

          (a)  This Warrant may be exercised, in whole at any time or in part
from time to time, commencing on the Initial Exercise Date and prior to 5:00
P.M. New York City time, on the Termination Date by the holder by the surrender
of this Warrant (with the subscription form at the end hereof duly executed) at
the address set forth in Subsection 9(a) hereof, together with proper payment of
the Aggregate Warrant Price, or the proportionate part thereof if this Warrant
is exercised in part, with payment for Warrant Shares made by certified or
official bank check payable to the order of the Company; or

          (b)  If this Warrant is exercised in part, this Warrant must be
exercised for a number of whole shares of the Common Stock and the Holder is
entitled to receive a new Warrant covering the Warrant Shares which have not
been exercised and setting forth the proportionate part of the Aggregate Warrant
Price applicable to such Warrant Shares.  Upon surrender of this Warrant, the
Company will (i) within a reasonable time but not longer than five (5) business
days issue a certificate or certificates in the name of the Holder for the
largest number of whole shares of the Common Stock to which the Holder shall be
entitled and, if this Warrant is exercised in whole, in lieu of any fractional
share of the Common Stock to which the Holder shall be entitled, pay to the
Holder cash in an amount equal to the fair value of such fractional share
(determined in such reasonable manner as the Board of Directors of the Company
shall determine), and (ii) deliver the other securities and properties
receivable upon the exercise of this Warrant, if any, or the proportionate part
thereof if this Warrant is exercised in part, pursuant to the provisions of this
Warrant.

     1a.  Number of Shares Issuable.  On June 30, 2002, Pictet will receive
          -------------------------
additional warrants to purchase common stock in an amount equal to 9.9% of the
increase in common stock outstanding during the period commencing on the date of
this warrant and ending on June 30, 2002.  Additional warrants will be issuable
on June 30, 2003 and June 30, 2004 based on the increase in common stock
outstanding for the years then ended.  Pictet's rights will terminate under this
provision once it has received additional warrants under this Section 1a
totaling 240,000 (an aggregate total of 400,000).  The exercise price of any
warrants issued under this Section 1a will equal the market price on the date of
issuance plus $.01.  However, such exercise price shall not be greater than
$4.75.

     2.   Reservation of Warrant Shares; Listing.  The Company agrees that,
          --------------------------------------
prior to the expiration of this Warrant, the Company will at all times (a) have
authorized and in reserve, and will keep available, solely for issuance or
delivery upon the exercise of this Warrant, the shares of the Common Stock and
other securities and properties as from time to time shall be receivable upon
the exercise of this Warrant, free and clear of all restrictions on sale or
transfer, except for the restrictions on sale or transfer set forth in the
Securities Act of 1933, as amended (the "Act"), and restrictions created by or
on behalf of the Holder, and free and clear of all preemptive rights and rights
of first refusal; and (b) if the Company prepares and files a registration
statement covering the shares of Common Stock issued or issuable upon exercise
of this Warrant with the Securities and Exchange Commission (the "SEC") which
registration statement is declared effective by the SEC under the Act and the
Company lists its Common Stock on any national securities exchange, it will use
its best efforts to cause the shares of Common Stock subject to this Warrant to
be listed on such exchange.

                                       2
<PAGE>

     3.   Protection Against Dilution.
          ---------------------------

          (a)  If, at any time or from time to time after the date of the
Warrant, the Company shall issue or distribute to the holders of shares of
Common Stock evidence of its indebtedness, any other securities of the Company
or any cash property or other assets (excluding a subdivision, combination or
reclassification, or dividend or distribution payable in shares of Common Stock,
referred to in Subsection 3(b), and also excluding cash dividends or cash
distributions paid out of net profits legally available therefor in the full
amount thereof, together with the value of other dividends and distributions
made substantially concurrently therewith or pursuant to a plan which includes
payment thereof, which is equivalent to not more than 5% of the Company's net
worth) (any such non-excluded event being herein called a "Special Dividend"),
the Per Share Warrant Price shall be adjusted by multiplying the Per Share
Warrant Price then in effect by a fraction, the numerator of which shall be the
then current Market Price of the Common Stock less the fair market value (as
determined in good faith by the Company's Board of Directors) of the evidence of
indebtedness, cash, securities or property, or other assets issued or
distributed in such Special Dividend applicable to one share of Common Stock and
the denominator of which shall be the then current Market Price of the Common
Stock.  An adjustment made pursuant to this Subsection 3(a) shall become
effective immediately after the record date of any such Special Dividend.

          (b)  In case the Company shall hereafter (i) pay a dividend or make a
distribution on its capital stock in shares of Common Stock, (ii) subdivide its
outstanding shares of Common Stock into a greater number of shares, (iii)
combine its outstanding shares of Common Stock into a smaller number of shares
or (iv) issue by reclassification of its Common Stock any shares of  capital
stock of the Company, the Per Share Warrant Price shall be adjusted to be equal
to a fraction, the numerator of which shall be the Aggregate Warrant Price and
the denominator of which shall be the number of shares of Common Stock or other
capital stock of the Company which he would have owned immediately following
such action had such Warrant been exercised immediately prior thereto.  An
adjustment made pursuant to this Subsection 3(b) shall become effective
immediately after the record date in the case of a dividend or distribution and
shall become effective immediately after the effective date in the case of a
subdivision, combination or reclassification.

          (c)  No adjustment in the Per Share Warrant Price shall be required in
the case of the issuance by the Company of (a) Common Stock pursuant to the
exercise of any Warrant, (b) options or warrants to purchase Common Stock
(including the exercise thereof) issued or sold to employees, officers or
directors of or consultants and advisers to the Company or any subsidiary
thereof, and (c) shares of Common Stock issued or sold pursuant to stock
purchase or stock option plans or other similar arrangements that are approved
by the Company's Board of Directors.

          (d)  In case of any capital reorganization or reclassification, or any
consolidation or merger to which the Company is a party other than a merger or
consolidation in which the Company is the continuing corporation, or in case of
any sale or conveyance to another entity of the property of the Company as an
entirety or substantially as an entirety, or in the case of any statutory
exchange of securities with another corporation (including any exchange effected
in connection with a merger of a third corporation into the Company), the Holder
of this Warrant shall have the right thereafter to receive on the exercise of
this Warrant the kind and amount of securities, cash or other property which the
Holder would have owned or have been entitled to receive immediately after such
reorganization, reclassification,

                                       3
<PAGE>

consolidation, merger, statutory exchange, sale or conveyance had this Warrant
been exercised immediately prior to the effective date of such reorganization,
reclassification, consolidation, merger, statutory exchange, sale or conveyance
and in any such case, if necessary, appropriate adjustment shall be made in the
application of the provisions set forth in this Section 3 with respect to the
rights and interests thereafter of the Holder of this Warrant to the end that
the provisions set forth in this Section 3 shall thereafter correspondingly be
made applicable, as nearly as may reasonably be, in relation to any shares or
other securities or property thereafter deliverable on the exercise of this
Warrant. The above provisions of this Subsection 3(d) shall similarly apply to
successive reorganizations, reclassifications, consolidations, mergers,
statutory exchanges, sales or conveyances. The issuer of any shares of stock or
other securities or property thereafter deliverable on the exercise of this
Warrant shall be responsible for all of the agreements and obligations of the
Company hereunder. Notice of any such reorganization, reclassification,
consolidation, merger, statutory exchange, sale or conveyance and of said
provisions so proposed to be made, shall be mailed to the Holders of the
Warrants not less than 30 days prior to such event. A sale of all or
substantially all of the assets of the Company for a consideration consisting
primarily of securities shall be deemed a consolidation or merger for the
foregoing purposes.

          (e)  In case any event shall occur as to which the other provisions of
this Section 3 are not strictly applicable but as to which the failure to make
any adjustment would not fairly protect the purchase rights represented by this
Warrant in accordance with the essential intent and principles hereof then, in
each such case, the Holders of Warrants representing the right to purchase a
majority of the Warrant Shares subject to all outstanding Warrants may appoint a
firm of independent public accountants of recognized national standing
reasonably acceptable to the Company, which shall give their opinion as to the
adjustment, if any, on a basis consistent with the essential intent and
principles established herein, necessary to preserve the purchase rights
represented by the Warrants.  Upon receipt of such opinion, the Company will
promptly mail a copy thereof to the Holder of this Warrant and shall make the
adjustments described therein.  The fees and expenses of such independent public
accountants shall be borne by the Company.

          (f)  No adjustment in the Per Share Warrant Price shall be required
unless such adjustment would require an increase or decrease of at least $0.05
per share of Common Stock; provided, however, that any adjustments which by
                           --------  -------
reason of this Subsection 3(g) are not required to be made shall be carried
forward and taken into account in any subsequent adjustment; provided, further,
                                                             -------- --------
however, that adjustments shall be required and made in accordance with the
provisions of this Section 3 (other than this Subsection 3(g)) not later than
such times as may be required in order to preserve the tax-free nature of a
distribution to the Holder of this Warrant or Common Stock issuable upon the
exercise hereof.  All calculations under this section 3 shall be made to the
nearest cent or to the nearest 1/100th of share, as the case may be.  Anything
in this Section 3 to the contrary notwithstanding, the Company shall be entitled
to make such reductions in the Per Share Warrant Price, in addition to those
required by this Section 3, as it in its discretion shall deem to be advisable
in order that any stock dividend, subdivision of shares or distribution of
rights to purchase stock or securities convertible or exchangeable for stock
hereafter made by the Company to its stockholders shall not be taxable.

          (g)  If the Board of Directors of the Company shall declare any
dividend or other distribution with respect to the Common Stock other than a
cash distribution out of earned surplus, the Company shall mail notice thereof
to the Holders of the Warrants not less than 15

                                       4
<PAGE>

days prior to the record date fixed for determining stockholders entitled to
participate in such dividend or other distribution.

          (h)  If, as a result of an adjustment made pursuant to this Section 3,
the Holder of any Warrant thereafter surrendered for exercise shall become
entitled to receive shares of two or more classes of capital stock or shares of
Common Stock and other capital stock of the Company, the Board of Directors
(whose reasonable determination shall be conclusive and shall be described in a
written notice to the Holder of any Warrant promptly after such adjustment)
shall determine the allocation of the adjusted Per Share Warrant Price between
or among shares or such classes of capital stock or shares of Common Stock and
other capital stock.

     4.   Fully Paid Stock; Taxes.  The Company agrees that the shares of the
          -----------------------
Common Stock represented by each and every certificate of Warrant Shares
delivered on the exercise of this Warrant will be validly issued and
outstanding, fully paid and nonassessable, and not subject to preemptive rights
or rights of first refusal, and the Company will take all such actions as may be
necessary to assure that the par value or stated value, if any, per share of the
Common Stock is at all times equal to or less than the then Per Share Warrant
Price.  The Company further covenants and agrees that it will pay, when due and
payable, any and all Federal and State stamp, original issue or similar taxes
which may be payable in respect of the issue of any Warrant Share or any
certificate thereof.

     5.   Registration Under Securities Act of 1933.  The Company agrees that
          -----------------------------------------
if, at any time and from time to time during the period commencing on the date
hereof and ending on the Termination Date, the Board of Directors of the Company
shall authorize the filing of a registration statement under the Act other than
a registration statement on Form S-8, S-4 or other form which does not include
substantially the same information as would be required in a form for the
general registration of securities) in connection with the proposed offer of any
of its securities by it or any of its stockholders, the Company will (i)
promptly notify that such registration statement will be filed and that the
Warrant Shares which are then held, and/or may be acquired upon exercise of the
Warrants by Pictet will be included in such registration statement at Pictet's
request, (ii) cause such registration statement to cover all of such Common
Stock which it has been so requested to include, (iii) use its best efforts to
cause such registration statement to become effective as soon as practicable and
(iv) take all other action necessary under any Federal or state law or
regulation of any governmental authority for the period necessary for Pictet to
effect the proposed sale or other disposition; provided, however, that such
period and the period during which the Company is required to keep the
registration statement effective in connection with this Section shall not
exceed the earlier of (A) 180 days from the date of effectiveness of such
registration statement under the Act and (B) the date upon which Pictet has
completed the sale or other disposition of the Warrant Shares; provided,
further, however that such period shall be extended for a period of time, not to
exceed 120 days, equal to the period Pictet refrains from selling or disposing
of any Warrant Shares in such registration at the request of the underwriter.

                                       5
<PAGE>

     6.   Limited Transferability.  This Warrant may not be sold, transferred,
          ------------------------
assigned or hypothecated by the Holder (a) except in compliance with the
provisions of the Act and the applicable state securities "blue sky" laws, and
(b) until the first anniversary hereof except (i) to any successor firm or
corporation of Pictet Global Sector Fund-Biotech, (ii) to any of the officers or
employees of Pictet Global Sector Fund-Biotech, or any such successor firm or
(iii) in the case of an individual, pursuant to such individual's last will and
testament or the laws of descent and distribution, and is so transferable only
upon the books of the Company which it shall cause to be maintained for such
purpose.  The Company may treat the registered Holder of this Warrant as he or
it appears on the Company's books at any time as the Holder for all purposes.
The Company shall permit any Holder of a  Warrant or his duly authorized
attorney, upon written request during ordinary business hours, to inspect and
copy or make extracts from its books showing the registered holders of Warrants.
All warrants issued upon the transfer or assignment of this Warrant will be
dated the same date as this Warrant, and all rights of the holder thereof shall
be identical to those of the Holder.

     7.   Loss, Etc., of Warrant.  Upon receipt of evidence reasonably
          ----------------------
satisfactory to the Company of the loss, theft, destruction or mutilation of
this Warrant, and of indemnity reasonably satisfactory to the Company, if lost,
stolen or destroyed, and upon surrender and cancellation of this Warrant, if
mutilated, the Company shall execute and deliver to the Holder a new Warrant of
like date, tenor and denomination.

     8.   Warrant Holder Not Shareholder.  Except as otherwise provided herein,
          ------------------------------
this Warrant does not confer upon the Holder any right to vote or to consent to
or receive notice as a stockholder of the Company, as such, in respect of any
matters whatsoever, or any other rights or liabilities as a stockholder, prior
to the exercise hereof.

     9.   Communication.  No notice or other communication under this Warrant
          -------------
shall be effective unless, but any notice or other communication shall be
effective and shall be deemed to have been given if, the same is in writing and
is mailed by first-class mail, postage prepaid, addressed to:

          (a)  The Company at 137 Newbury Street, 8th Floor, Boston, MA 02116 or
other address as the Company has designated in writing to the Holder, or

          (b)  the Holder at Pictet Global Sector Fund-Biotech, c/o Pictet &
Cie, Bd Georges-Favon 29, Case postale 5130, CH-1211 Geneva, Switzerland Attn:
Dr. Vincent Ossipow or other such address as the Holder has designated in
writing to the Company, with a copy to Mr. Yves Martignier, Pictet & Cie, Bd
Georges-Favon 29, Case postale 5130, CH-1211 Geneva, Switzerland.

     10.  Headings.    The headings of this Warrant have been inserted as a
          --------
matter of convenience and shall not affect the construction hereof.

     11.  Applicable Law.  This Warrant shall be governed by and construed in
          --------------
accordance with the law of the State of Delaware without giving effect to the
principles of conflicts of law thereof.

                                       6
<PAGE>

IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its
Executive Vice President on the date indicated below.

                                        BOSTON LIFE SCIENCES, INC.

                                        By: /s/ Joseph Hernon
                                           -------------------------------
                                           Joseph Hernon
                                           Chief Financial Officer

                                        Date: June 25, 2001
                                             -----------------------------

                                       7
<PAGE>

                                  SUBSCRIPTION
                                  ------------

          The undersigned, _______________________, pursuant to the provisions
of the foregoing Warrant, hereby agrees to Subscribe for and purchase
________________ shares of the Common Stock, par value $.01 per share, of Boston
Life Sciences, Inc. covered by said Warrant, and makes payment therefor in full
at the price per share provided by said Warrant.

Dated:__________________           Signature:__________________________________

                                   Address:____________________________________

                                           ____________________________________

                                   ASSIGNMENT
                                   ----------

          FOR VALUE RECEIVED______________ hereby sells, assigns and transfers
unto ______________________the foregoing Warrant and all right evidenced
thereby, and does irrevocably constitute and appoint __________________________,
attorney, to transfer said Warrant on the books of Boston Life Sciences, Inc.

Dated:__________________           Signature:__________________________________

                                   Address:____________________________________

                                           ____________________________________

                               PARTIAL ASSIGNMENT
                               ------------------

          FOR VALUE RECEIVED __________________ hereby assigns and transfers
unto ________________________ the right to purchase ___________ shares of the
Common Stock, par value $.01 per share, of Boston Life Sciences, Inc. covered by
the foregoing Warrant, and a proportionate part of said Warrant and the rights
evidenced thereby, and does irrevocably constitute  and appoint
____________________________, attorney, to transfer that part of said Warrant on
the books of Boston Life Sciences, Inc.

Dated:__________________           Signature:__________________________________

                                   Address:____________________________________

                                           ____________________________________

                                       8

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