Document:

AMENDMENT
      TO

     

    UNIT
      PURCHASE OPTION

     

    This
      AMENDMENT TO UNIT PURCHASE OPTION (this ‘‘Amendment’’), dated January 23, 2007,
      is made by and between Healthcare Acquisition Corp. (the ‘‘Company’’)
      and
      the holder designated on the signature page hereof (‘‘Holder’’),
      to
      that certain Unit Purchase Option referred to below.

     

    WHEREAS,
      the Company issued that certain Unit Purchase Option, dated July 28, 2006 (the
      ‘‘Unit
      Purchase Option’’),
      in
      connection with the Company’s initial public offering and the Holder is the
      owner of the Unit Purchase Option; and

     

    WHEREAS,
      the parties hereto have agreed that the Unit Purchase Option be amended as
      set
      forth herein to clarify the understanding between the parties with respect
      to
      the terms of the Unit Purchase Option effective as of the date of its
      issuance.

     

    NOW,
      THEREFORE, in consideration of the premises and of the agreements contained
      herein, the parties hereto hereby agree as follows:

     

    1. To
      reflect the original intention of the parties, Section
      5.3, Damages,
      of the
      Unit Purchase Option is and shall be amended and restated in its entirety as
      follows:

     

    “5.3 Potential
      Expiration; No Obligation to Net-Cash Settle.
      Notwithstanding anything to the contrary contained in this Purchase Option,
      if
      the Company is unable to deliver any securities pursuant to the exercise of
      this
      Purchase Option as a result of its inability to satisfy its registration
      requirements set forth in Section 5 hereof, or an exemption from the
      registration requirements of the Securities Act of 1933, as amended, does not
      exist, the Purchase Option and the underlying securities may expire unexercised
      or unredeemed and the Company will have no obligation to pay such registered
      holder any cash or otherwise “net-cash settle” the Purchase Option or the
      Warrants underlying the Purchase Option.”

     

    2. Upon
      the
      due execution and delivery of this Amendment by the parties hereto, on and
      after
      the date hereof each reference in the Unit Purchase Option to this ‘‘Purchase
      Option’’, ‘‘hereunder’’, ‘‘hereof’’, ‘‘herein’’ or words of like import
      referring to the Unit Purchase Option shall mean and be a reference to the
      Unit
      Purchase Option, as amended hereby. Except as specifically amended above, the
      Unit Purchase Option shall remain in full force and effect and is hereby
      ratified and confirmed.

     

    3. This
      Amendment may be executed in one or more counterparts, and by the different
      parties hereto in separate counterparts, each of which shall be deemed to be
      an
      original, but all of which taken together shall constitute one and the same
      agreement, and shall become effective when one or more counterparts has been
      signed by each of the parties hereto and delivered to each of the other parties
      hereto.

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    IN
      WITNESS WHEREOF, the parties have executed this AMENDMENT TO UNIT PURCHASE
      OPTION as of the date first set forth above.

     

    

     

    
      	 	 	
              HEALTHCARE
                ACQUISITION CORP.

            
	 	 	 
	 	 	 
	 	 	 
	 	
              By:
                

            	
              /s/
                Matthew P. Kinley

            
	 	 	
              Name:
                Matthew P. Kinley

            
	 	 	
              Title:
                President

            
	 	 	 
	 	 	 
	
               

            	 	 
	 	 	
              HOLDER

            
	 	 	 
	 	 	 
	 	 	
              Maxim
                Partners, LLC

            
	
               

            	 	 
	 	 	 
	 	 	 
	 	 	 
	 	
              By:

            	
              /s/
                Edward Rose

            
	 	 	
              Name:
                Edward Rose

            
	 	 	
              Title:
                Vice Chairman

            

    

    

     

    
      
         

      

      
        2WARRANT
      CLARIFICATION AGREEMENT

    

    This
      Warrant Clarification Agreement (this “Agreement”), dated January 23, 2007, is
      to the Warrant Agreement, dated as of July 28, 2005 (the “Warrant Agreement”),
      by and between Healthcare Acquisition Corp., a Delaware corporation (“Company”),
      and Continental Stock Transfer & Trust Company, a New York corporation
      (“Warrant Agent”).

    

    WHEREAS,
      Section
      3.3.2 of the Warrant Agreement provides that Company shall not be obligated
      to
      deliver any securities pursuant to the exercise of a warrant unless a
      registration statement under the Securities Act of 1933, as amended (“Securities
      Act”), with respect to the common stock is effective.

    

    WHEREAS,
      in
      furtherance of the foregoing, the Company’s final prospectus, dated July 28,
      2005, indicated (i) that no warrant would be exercisable unless at the time
      of
      exercise a prospectus relating to the common stock issuable upon exercise of
      the
      warrant is current and the common stock has been registered under the Securities
      Act or qualified or deemed to be exempt under the securities laws of the state
      of residence of the holder of the warrant and (ii) that the warrant may be
      deprived of any value and the market for the warrant may be limited if the
      prospectus relating to the common stock issuable upon the exercise of the
      warrant is not current or if the common stock is not qualified or exempt from
      qualification in the jurisdictions in which the holder of the warrant
      resides.

    

    WHEREAS,
      as a
      result of certain questions that have arisen regarding the accounting treatment
      applicable to the warrants, the parties hereto deem it necessary and desirable
      to amend the Warrant Agreement to clarify that the registered holders do not
      have the right to receive a net cash settlement in the event the Company does
      not maintain a current prospectus relating to the common stock issuable upon
      exercise of the warrants at the time such warrants are exercisable.

    

    NOW,
      THEREFORE,
      in
      consideration of the mutual agreements contained herein and other good and
      valuable consideration, the receipt and sufficiency of which are hereby
      acknowledged, and intending to be legally bound hereby, the parties hereto
      agree
      to amend the Warrant Agreement as set forth herein.

    

    1. Warrant
      Agreement.
      The
      Warrant Agreement is hereby clarified by adding the following sentence as the
      penultimate sentence of Section 3.3.2:

    

    “Accordingly,
      the Warrants may expire unexercised or unredeemed if there is no effective
      registration statement and the Company would have no obligation to pay such
      registered holder any cash or other consideration or otherwise “net cash settle”
the Warrant.”

    

    2. Miscellaneous.

    

    (a)
      Governing
      Law.
      The
      validity, interpretation, and performance of this Agreement and of the Warrants
      shall be governed in all respects by the laws of the State of New York, without
      giving effect to conflicts of law principles that would result in the
      application of the substantive laws of another jurisdiction. The Company hereby
      agrees that any action, proceeding or claim against it arising out of or
      relating in any way to this Agreement shall be brought and enforced in the
      courts of the State of New York or the United States District Court for the
      Southern District of New York, and irrevocably submits to such jurisdiction,
      which jurisdiction shall be exclusive. The Company hereby waives any objection
      to such exclusive jurisdiction and that such courts represent an inconvenient
      forum. Any such process or summons to be served upon the Company may be served
      by transmitting a copy thereof by registered or certified mail, return receipt
      requested, postage prepaid, addressed to it at the address set forth in Section
      9.2 of the Warrant Agreement. Such mailing shall be deemed personal service
      and
      shall be legal and binding upon the Company in any action, proceeding or
      claim.

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (b)
      Binding
      Effect.
      This
      Agreement shall be binding upon and inure to the benefit of the parties hereto
      and to their respective heirs, legal representatives, successors and
      assigns.

     

    (c)
      Entire
      Agreement.
      This
      Agreement sets forth the entire agreement and understanding between the parties
      as to the subject matter thereof and merges and supersedes all prior
      discussions, agreements and understandings of any and every nature among them.
      Except as set forth in this Agreement, provisions of the Warrant Agreement
      which
      are not inconsistent with this Agreement shall remain in full force and effect.
      This Agreement may be executed in counterparts.

     

    (d)
      Severability.
      This
      Agreement shall be deemed severable, and the invalidity or unenforceability
      of
      any term or provision hereof shall not affect the validity or enforceability
      of
      this Agreement or of any other term or provision hereof. Furthermore, in lieu
      of
      any such invalid or unenforceable term or provision, the parties hereto intend
      that there shall be added as part of this Agreement a provision as similar
      in
      terms to such invalid or unenforceable provision as may be possible and be
      valid
      and enforceable.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    IN
      WITNESS WHEREOF, the parties hereto have executed this Warrant Clarification
      Agreement as of the date first written above.

    

    

    
      	 	
              HEALTHCARE
                ACQUISITION CORP.

            
	 	 	 
	 	
              By:

            	
              /s/
                Matthew P. Kinley

            
	 	 	
              Name:
                Matthew P. Kinley

            
	 	 	
              Title:
                President

            
	 	 	 
	 	 	 
	 	 	 
	 	
              CONTINENTAL
                STOCK TRANSFER & TRUST COMPANY

            
	 	 	 
	 	
              By:

            	
              /s/ Felix
                Orihuela

            
	 	 	
              Name:
                Felix Orihuela

            
	 	 	
              Title:
                Vice President

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