Document:

Exhibit 4.9

 

THE SECURITIES REPRESENTED HEREBY HAVE
NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”), THE ISRAELI
SECURITIES LAW OF 1968 (THE “SECURITIES LAW”) OR ANY APPLICABLE STATE SECURITIES LAWS. IN THE ABSENCE OF AN
EFFECTIVE REGISTRATION STATEMENT UNDER THE 1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS, THESE SECURITIES MAY NOT BE OFFERED,
SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS.

 

Loan
Agreement

 

This
Loan Agreement is made and entered into as of the date set forth on the signature page below by and between RedHill Biopharma
Ltd., a company organized and registered under the laws of the State of Israel, with offices at 42 Givati Street, Ramat-Gan, 52232,
Israel (“Borrower”) and the person or entity whose name, signature and address appear on the signature page
hereof (“Lender”).

 

	Whereas,	Borrower seeks funds in a total amount of up to $4,000,000 (the “Aggregate Total Funds”) as convertible loans on the terms set forth in this Agreement (“Acquisition Financing Loans”) from various lenders including Lender (all such lenders, including Lender, providing Convertible Lender Loans to Borrower on terms similar to those of this Agreement, shall be referred to collectively as “Acquisition Financing Lenders”); and
	 	 
	Whereas,	Lender is willing to lend to Borrower the amount set forth on the signature page hereunder as an Acquisition Financing Loan for part of the Aggregate Total Funds and Borrower desires to borrow from Lender such amount, on the terms and conditions set forth herein;

 

NOW, THEREFORE, the parties
agree as follows:

 

1.          Loan.
Lender shall lend to Borrower and Borrower shall borrow from Lender the principal amount set forth on the signature page
hereof (the “Loan”). The Loan shall be delivered to Borrower by deposit no later than July 15, 2010 in Borrower’s
bank account listed in Exhibit A annexed hereto.

 

2.          Interest.
The Loan shall bear interest on its outstanding principal amount in US Dollars, at a per annum rate equal to eight percent (8%),
compounded annually (“Interest”). Interest shall accrue and not be payable until the Loan is converted pursuant
to the provisions of Section 4 below. The principal amount of the Loan together with accrued Interest is hereinafter referred as
the “Loan Amount”.

 

3.          Use
of Proceeds. Borrower undertakes that the entire amount of the Loan shall be used for the purpose of funding acquisition
of one or more products and/or in-licensing transactions, clinical trials, and general corporate activity.

 

    	 

    	 

    

 

4.          Mandatory
Conversion. 

 

The Loan
Amount shall be convertible as follows:

 

		(a)	Unless previously converted, in the event that at any time prior to August 31, 2010, Borrower shall
close a convertible loan financing, or series of related convertible loan financings in a minimum aggregate amount of $1,500,000
(One Million Five Hundred Thousand US Dollars) (a “Convertible Loan Financing”), other than the Acquisition
Lender Loans, the entire outstanding Loan Amount shall automatically convert into a convertible loan on the same terms as the loans
advanced in the Convertible Loan Financing. In the event that the terms of the Convertible Loan Financing are less favorable to
Lender than the terms of set out in Exhibit B annexed hereto, Lender shall be entitled to convert the Loan Amount
to a convertible loan on the terms set out in Exhibit B.

 

		(b)	Unless previously converted, in the event that at any time prior to August 31, 2010, Borrower shall
close an equity investment, or series of related equity investments, in a minimum aggregate amount of $1,500,000 (One Million Five
Hundred Thousand US Dollars) (excluding any conversion of the Acquisition Financing Loans) (an “Equity Financing”),
Lender shall be entitled to convert the entire outstanding Loan Amount into an investment on the same terms as the Equity Financing
and Borrower shall issue to Lender the number of shares of the class of equity securities issued in the Equity Financing as is
obtained by dividing (i) the outstanding Loan Amount as of the closing date of the Equity Financing by (ii) the price per share
paid by the investors in the Financing Round.

 

		(c)	Unless previously converted, on August 31, 2010 the Loan Amount shall be automatically converted
into a convertible loan on the terms set out in Exhibit B annexed hereto.

 

		(d)	Upon conversion of the Loan Amount as aforesaid, the Loan and all Interest accrued thereon shall
be deemed fully repaid and Lender shall have no further rights with respect to the Loan and Interest accrued thereon. Notwithstanding
the foregoing, the right to receive royalties pursuant to Section 5 hereof will continue without regard to any conversion or repayment
of the Loan and shall not be appurtenant or incidental to any securities issued on conversion of the Loan.

 

5.          Royalties.
Lender, together with all other Acquisition Financing Lenders, shall be entitled to receive royalty payments on the terms described
in Exhibit C annexed hereto.

 

6.          Representations
and Warranties of Borrower. Borrower hereby represents and warrants to Lender as follows:

 

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(a)          Organization.

 

(i)          Borrower
is an Israeli private company duly organized and validly existing under the laws of the State of Israel and has all requisite corporate
power and authority to own and operate its properties and assets and to carry on its business as now conducted.

 

(ii)         No
proceeding or resolution for bankruptcy, dissolution, liquidation, winding-up, scheme of arrangement with creditors, appointment
of receiver or liquidator and/or similar proceeding has been instituted or taken by Borrower, and to the best of Borrower's knowledge,
no such proceeding and no “freezing or stay of process order” has been instituted, threatened or applied for against
Borrower.

 

		(b)	Authority. Borrower has full corporate power and authority to enter into, execute, deliver
and perform this Agreement, to bind itself hereunder, to comply with its obligations hereunder and to carry out the provisions
hereof and thereof.

 

		(c)	Licenses. Borrower has entered into definitive in-licenses with SCOLR Pharma Inc. in respect
of rights to extended release Ondanstron tablet formulation and Egalet a/s in respect of rights to Carvedilol, respectively. Borrower
has also entered into binding term sheets with IntelGenx Technologies Corp. in respect of Rizatriptan and Giaconda Limited in respect
of Myoconda (a drug for Crohn's disease), Heliconda and Picoconda.

 

7.          Representations
and Warranties of Lender. Lender hereby represents and warrants to Borrower as follows:

 

		(a)	Organization. If other than an individual, Lender is duly organized, properly registered
and validly existing under the law of the jurisdiction of its organization. No proceeding or resolution for bankruptcy, dissolution,
liquidation, winding-up, appointment of a receiver and/or similar proceeding has been instituted or taken by Lender, and, to the
best of Lender knowledge, no such proceeding has been instituted or threatened against Lender.

 

		(b)	Authority. Lender has the full power and authority to enter into, execute and deliver this
Agreement, bind itself hereunder, comply with its obligations hereunder, and consummate the transactions contemplated hereunder;
the entering into and the execution, delivery and performance by it of this Agreement, and the transactions contemplated hereunder,
have been duly approved and authorized by all the required corporate actions, and this Agreement was signed by its duly authorized
representatives, where required, and constitutes a valid and legally binding obligation on it, enforceable in accordance with its
respective terms, subject to and limited by (a) applicable bankruptcy, insolvency, reorganization, moratorium, and other laws generally
applicable to creditors’ rights, and (b) judicial discretion in the availability of equitable relief. The execution, delivery
and performance of this Agreement and all other related documents do not violate Lender's governing documents or any agreement
to which Lender is a party or by which it is bound.

 

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		(c)	Required Consents. No approval, authorization or consent from any person, entity or authority,
is required by it for the execution, delivery and performance by it of this Agreement.

 

		(d)	Investment Experience. Lender is an investor in securities of companies in the development
stage, and is able to fend for itself, can bear the economic risk of its investment and has such knowledge and experience in financial
and business matters that it is capable of evaluating the merits and risks of its grant of the Loan to Borrower as a company in
the research and development stage. Lender has the ability to bear the full economic risk of its Loan pursuant to this Agreement.
Lender also represents that it has (i) performed its own independent review of the data and documents it requested and received
from Borrower in connection with Borrower and this Agreement; (ii) been given the opportunity to ask questions of and receive
answers from Borrower regarding Borrower, the terms and conditions of its shares, and Borrower's current and proposed business,
operations, properties, prospects, legal and financial condition; and (iii) reached the decision to lend funds to Borrower
as a result of, inter alia, careful consideration.

 

		(e)	Investment Purpose. Lender is providing the Loan for investment for its account, not as
nominee or agent, and not with a current view to the resale or distribution of any part thereof, and Lender has no present intention
of selling, granting any participation in or otherwise distributing the same. Lender understands that the any securities to be
issued on conversion of the Loan have not been, and will not be, registered under the US Securities Act of 1933 (the “Securities
Act”) by reason of a specific exemption from the registration provisions of the Securities Act, the availability of which
depends upon, among other things, the bona fide nature of the investment intent and the accuracy of Lender's representations as
expressed herein.

 

		(f)	Accredited Investor. If Lender is a U.S. Person (as defined in Regulation S promulgated
under the Securities Act), it represents to Borrower that Lender is an Accredited Investor (as defined in Rule 501 of Regulation
D promulgated under the Securities Act). Lender also represents that Lender has not been organized for the purpose of providing
the Loan.

 

8.          Default.
The entire Loan Amount will immediately become due and payable upon any of the following events of default:

 

		(a)	the commencement by Borrower of any liquidation proceedings or the adoption of a winding up resolution
by Borrower, or the appointment of a receiver or trustee over the whole or a substantial part or Borrower's assets, or the calling
by Borrower of a meeting of creditors for the purpose of entering into a scheme or arrangement with them, and if any of the aforementioned
actions or proceedings is not canceled within sixty (60) days of its initiation; or

 

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		(b)	the levy of an attachment or the institution of execution proceedings against the whole or a substantial
part of Borrower's assets, where such attachment or execution proceeding is not discharged within sixty (60) days. Borrower shall
notify Lender within 72 hours of any such attachment or proceeding.

 

9.          Confidentiality.
Lender undertakes that all information concerning Borrower, which comes into its possession or to its attention, whether
pursuant to this Agreement, as a shareholder of Borrower or otherwise, including audited and unaudited financial statements of
Borrower, and all other financial, technical and other information relating to Borrower, will be kept in the strictest confidence
and will not, without the prior written consent of Borrower, be used by it or be disclosed to, or discussed with, any third party
provided, however, in the event that Lender is required by law or stock exchange rule to include financial information obtained
pursuant to this Agreement in reports to governmental authorities or stock exchanges, Lender shall be entitled to make such disclosure
to the minimum extent required, and provided, further, that in connection with periodic reports to its shareholders or partners,
Lender may, without first obtaining the prior written consent of Borrower, make general statements, not containing technical, commercially
sensitive or other confidential information, regarding the general nature of Borrower, and may provide summary and general information
regarding Borrower’s revenues and profits to its lawyers and accountants, and in its reports to its shareholders and partners,
but may not annex to such reports the full financial information to be provided by Borrower except as required by applicable law
and regulations. Notwithstanding the above, the undertaking of confidentiality will not apply to:

 

(i)          Information
which is in the public domain at the time of disclosure or subsequently becomes part of the public domain, except by breach by
a party hereto of its obligations hereunder; or

 

(ii)         Information
which is received from a third party, provided that such information was not obtained by said third party directly or indirectly
from Borrower pursuant to obligations of confidentiality; or

 

(iii)        Information
which must be disclosed under applicable laws or regulations but only to the extent so required; provided, however, that in the
event Lender feels that circumstances exist which require such disclosure, it shall notify Borrower thereof, and provide Borrower
with a copy of such proposed disclosure or notice, promptly and, where possible, in a manner which will enable Borrower to oppose
such disclosure within the period of time allotted under such laws or regulations for submission of the disclosure or notice.

 

10.         Governing
Law and Forum. This Agreement, its interpretation, validity and breach shall be governed by the laws of the State of
Israel, without regard to its conflict of laws rules, and any claim or dispute with respect thereto shall be submitted to the exclusive
jurisdiction of the competent courts of Tel-Aviv, Israel, and each of the parties hereby submits irrevocably to the jurisdiction
of such court to the exclusion of any other jurisdiction and agrees to the service of process by post in accordance with the provisions
of Section 11(i) below.

 

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11.         Miscellaneous.

 

(a)          Further
Cooperation. The parties agree to execute any and all documents necessary in order to consummate, implement and give full force
and effect to this Agreement, and to all matters, actions and transactions envisaged and contemplated herein including, filings
with governmental or regulatory bodies, corporate resolutions and such other documentation as may be reasonably necessary from
time to time.

 

(b)          No
Partnership. The parties to this Agreement are independent contractors. There is no relationship of partnership, joint venture,
employment, franchise or agency between the parties. No party will have the power to bind the other or incur obligations on the
other's behalf without the other's prior written consent.

 

(c)          Construction.
A reference to a Section, Exhibit or Schedule shall mean a Section in or Exhibit or Schedule to this Agreement, unless otherwise
expressly stated. The titles and headings herein are for reference purposes only and shall not have any significance in the interpretation
of this Agreement nor in any manner limit the construction of this Agreement which shall be considered as a whole. The words “include,”
“includes” and “including” when used herein shall be deemed in each case to be followed by the words “without
limitation.” Whenever the context may require, any pronouns used herein shall include the corresponding masculine, feminine
or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. The plural of any defined
term shall have a meaning correlative to such defined term and words denoting any gender shall include all genders and the neuter.
Where a word or phrase is defined herein, each of its other grammatical forms shall have a corresponding meaning. The parties have
participated jointly in the negotiation and drafting of this Agreement. If any ambiguity or question of intent or interpretation
arises, this Agreement shall be construed as if drafted jointly by the parties, and no presumption or burden of proof shall arise
favoring or disfavoring any party by virtue of the authorship of any provision of this Agreement.

 

(d)          Counterparts;
Facsimile. This Agreement may be executed in any number of counterparts, and at one or more times, each of which containing
the signature of any of the parties, shall be deemed an original, but all of which together shall constitute one and the same instrument.
Any copy of this Agreement executed with an original signature and transmitted via facsimile shall be deemed valid.

 

(e)          Successors
and Assigns. Except as otherwise provided herein, the terms and conditions of this Agreement shall inure to the benefit of
and be binding upon the respective successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended
to confer upon any party other than the parties hereto or their respective successors and assigns, any rights, remedies, obligations,
or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement.

 

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None of the rights, privileges,
or obligations set forth in, arising under, or created by this Agreement may be assigned without the prior consent in writing of
each party to this Agreement, with the exception of an assignment by Lender to any other entity which controls, is controlled by
or is under common control with, Lender; provided, however, that no such assignment or transfer shall become effective unless each
such transferee has provided Borrower with a confirmation in writing that it is bound by all terms and conditions of this Agreement
and all the agreements contemplated hereby.

 

(f)          Severability.
If one or more provisions of this Agreement is held to be illegal, invalid or unenforceable under applicable law, such provision
shall be excluded from this Agreement, and the balance of the Agreement shall be interpreted as if such provision were so excluded
and shall be enforceable in accordance with its terms; provided, however, that in such event this Agreement shall be interpreted
so as to give effect, to the greatest extent consistent with and permitted by applicable law, to the meaning and intention of the
excluded provision as determined by such court of competent jurisdiction.

 

(g)          Amendments
and Waivers. The failure of any party at any time or times to require performance of any provision hereof or to enforce any
right with respect thereto, shall in no manner affect the right of such party at a later time to enforce the same and shall in
no way be construed to be a waiver of such provision or right.

 

(h)          Entire
Agreement. This Agreement and the exhibits attached hereto constitute the full and entire understanding and agreement among
the parties with regard to the subjects hereof and thereof, and no previous agreements, memoranda of agreements, letters, negotiations,
promises, consents, undertakings, representations, warranties or documents which were applied, exchanged, or signed by or between
any of the parties hereto prior to the signing of this Agreement shall have any force or effect. Any term of this Agreement may
be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance and either
retroactively or prospectively), in the context of a similar amendment or waiver in respect of the Acquisition Lender Loans with
the written consent of Borrower and Acquisition Financing Lenders who have provided a majority of the outstanding Aggregate Total
Amount provided as Acquisition Lender Loans.

 

(i)          Notices.
All notices and other communications required or permitted hereunder shall be in writing, shall be effective when given, and shall
in any event be deemed to be given upon receipt or, if earlier, (a) five (5) business days after the business day of deposit
with an express courier, freight prepaid; (b) upon delivery, if delivered by hand; or (c) one (1) business day after
the business day of facsimile transmission or e-mail, if delivered by facsimile transmission or sent by e-mail. All such notices
and other communications shall be addressed to the following addresses or such other address as the recipient party may designate
by ten (10) days advance written notice to the other party pursuant to the provisions above:

 

If
to Lender, as set forth on the signature page hereunder.

 

If
to Borrower:

 

RedHill
Biopharma Ltd.         

42
Givati Street

Ramat-Gan
52232, Israel

Fax:
972-3-7255723

Attn:
Ori Shilo

 

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(j)          Publicity.
Lender shall not, subject to the requirements or law, regulations or order, issue any press release or undertake any publicity
concerning the existence or any of the terms or provisions of this Agreement or any of the transactions contemplated hereby or
thereby without the prior written consent of Borrower.

 

(k)          Fees
and Expenses. The parties hereto shall each bear their own expenses and legal fees incurred by them or on their behalf with
respect to this Agreement and the transactions contemplated hereby.

 

[Remainder of page
intentionally left blank]

 

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SIGNATURE PAGE

 

IN WITNESS WHEREOF, the parties have executed
this Convertible Loan Agreement.

 

BORROWER

 

RedHill Biopharma Ltd.

 

	 	By:	 	 
	 	 	 	 
	 	Name:	 	 
	 	 	 	 
	 	Title:	 	 

 

	Date:	 	 

 

LENDER

 

	Name of Lender:	 	 

 

Signature of Lender:

 

	 	By:	 	 
	 	 	 	 
	 	Name:	 	 
	 	 	 	 
	 	Title:	 	 

 

	Principal Amount of Loan	 	 

 

	Address of Lender:	 	 
	 	 	 
	 	 	 

 

	Identity No./Company No.	 	 

 

	Facsimile No.	 	 
	 	 	 
	Date:	 	 

 

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Exhibit
A

 

RedHill
Biopharma - Bank Details

 

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Exhibit
B

 

Summary of Terms: Convertible Bridge
Loan Financing

 

Disclaimer:
This Summary of Terms does not constitute an offer or solicitation to participate in the financing described herein. An offer to
participate in the financing in certain jurisdictions may be restricted. The Company expects to make an offer of participation
in the financing only to persons to whom such offer would not constitute a violation of any law. In the United States an offer
will only be made to those who fall within the definition of "Accredited Investors" contained in Rule 501 of Regulation
D promulgated under the U.S. Securities Act of 1933, as Amended.

 

	Issuer	RedHill Biopharma Ltd., an Israeli company (the “Company”).
	 	 
	Financing	Up to $4.0 million or other amount specified by the Company in convertible loan notes (the “Notes”).
	 	 
	Interest	8% per annum.
	 	 
	Warrants	30% coverage; 36 months term; strike price as described below.
	 	 
	Mandatory Conversion	At the earlier of the following events the principal and all accrued interest shall be automatically converted as follows: 

 

		·	M&A, public listing,
or financing of at least US $3.0 million (not including the current financing) (Qualified Event/s): conversion at 70% of
Qualified Event price per share to the same class of shares issued in the Qualified Event. 

 

		·	December 31, 2011: conversion at Company
pre-money valuation (fully diluted) of $7 million. In this case the Notes will be converted into the most senior class of shares
issued by the Company at such time.

 

	Conversion Price Protection	The Conversion Price shall not exceed a Company pre-money valuation (on fully diluted basis) of more than $12 million.
	 	 
	Warrants Exercise Price	Within 6 months following the first Qualified Event (Initial Exercise Period): 130% of the price per share in the first mandatory conversion event. 
	 	 
	 	Within 6 months following the end of the Initial Exercise Period (Second Exercise Period): 140% of the price per share in the first mandatory conversion event.
	 	 
	 	Following the end of the Second Exercise Period until the expiration date of the Warrants: 150% of the price per share in the first mandatory conversion event.
	 	 
	Use of Proceeds	Research and Development and general working capital purposes.
	 	 
	Target Closing	June 30, 2010 or other date specified by the Company.
	 	 
	Confidentiality	Except as required under any applicable law, the investor shall not disclose to any third party any information relating to the Company’s business, operation, assets or the terms herein.

 

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Exhibit C

 

Royalties

 

Royalties. Lender, together with
the other Acquisition Financing Lenders, shall be entitled to receive royalties (“Royalties”) equaling a percentage
of Net Sales and Sublicense Revenues (as such terms are defined below) actually received by Borrower from the Designated
Products (as defined below).

 

Royalty Term. Royalties on Net Sales
and on Sublicense Revenues actually received by RedHill from sales of Designated Products by sublicensees shall be payable during
the period of five (5) years following the first commercial sale of the first Designated Product to have a commercial sale. Royalties
in respect of Sublicense Revenues other than in respect of sales of Designated Products (e.g., upfront and milestone payments)
shall be payable during the period of five (5) years following closing of the Acquisition Financing Loans transaction.

 

Royalty Percentage. Royalties will
be distributed to the Acquisition Financing Lenders on a pro rata basis according to their relative participation in the principal
amount of the Aggregate Total Amount of the Acquisition Financing Loans and shall be equal to an aggregate of three percent (3%)
of Net Sales and Sublicense Revenues if the Total Aggregate Amount of the Acquisition Financing Loans is up to $1,500,000; four
percent (4%) if the Total Aggregate Amount of the Acquisition Financing Loans is greater than $1,500,000 and up to $2,000,000 and
five percent (5%) if the Total Aggregate Amount of the Acquisition Financing Loans is greater than $2,000,000.

 

Definitions. For the purposes of
this Exhibit, the following terms shall have the following meanings:

 

“Net Sales” means
the amounts actually received by Borrower or its affiliates in respect of the sale of Designated Products by Borrower or its affiliates,
less, and following recovery of, the following items (collectively, the “Recognized Deductions”): (i) allowances
or credits granted to and taken by customers (including wholesalers) for warranties, rejections, returns (including as a result
of recalls), and prompt payment and trade, cash and volume discounts or resulting from inventory management; (ii) amounts incurred
resulting from government mandated rebate programs (or any agency thereof); (iii) freight, transport, packing and insurance charges;
(iv) taxes, including value added tax, sales tax, and other taxes not imposed on Borrower's income; and (v) tariffs and import/export
or customs duties; (vi) bad debts; (vii) reasonable quantities of samples; and (viii) royalties paid to third parties in respect
of the use of such third party’s intellectual property rights necessary for the exercise of the License. 

 

For the purposes of this definition, the
transfer of a Designated Product by Borrower or one of its affiliates to another affiliate of Borrower or to a sublicensee for
resale is not a sale and in such cases, Net Sales will be determined based on the amount received by Borrower or such affiliate
in respect of the Product or “Combination Product” (subject to the adjustments set forth below) as sold by the affiliate
or sublicensee to independent third-parties, less the Recognized Deductions.

 

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For Net Sales of a Designated Product sold
or supplied as a “Combination Product”, the Net Sales of such a Combination Product in a country will be determined
by multiplying the Net Sales of such Combination Product by the fraction of A/A+B, where A is the average unit selling price during
the period in respect of which Net Sales are being calculated of the Product sold separately in that country and B is the total
average unit selling price during the period in respect of which Net Sales are being calculated of the other product or device
included in the Combination Product, when sold separately in that country. If neither the Product nor the other product or device
included in the Combination Product are sold separately during the period in respect of which Net Sales are being calculated, then
the parties shall, considering the costs incurred by Borrower bringing about the Combination Product, in good faith negotiate the
value of the other product or device included in the Combination Product that are to be deducted from the Net Sales of the Combination
Product in determining the Net Sales of the Product contained in the Combination Product, it being agreed that absent such mutual
agreement as to the proportion of such Combination Product to be attributed to the Product, the parties shall mutually appoint
an independent expert to determine such proportion.

 

In addition, in cases where Borrower manufactures
the Product (including manufacture for a Sublicensee) or Borrower purchases the Product from a third party and sells the Product
through a distributor, Sublicensee or pharma partner, all costs associated with the manufacture and production of the Product,
including without limitation, the costs of labor, (including employees, consultants and service providers), raw materials, premises
(including rent and ancillary costs), overhead, manufacturing equipment, and the costs of the insurance of same shall be included
in Recognized Deductions.

 

“Sublicense Revenues”
means royalties actually received by Borrower from third party distributors and/or sublicensees in respect of the sublicense
of rights in the Designated Product and of sales of the Product effected by such distributors and/or sublicensees, excluding, for
example but without limitation, payments on account of (i) debt financing; (ii) equity (and conditional equity, such as warrants,
convertible debt and the like) investments in Borrower or any affiliate thereof; and (iii) reimbursement of patent prosecution
costs, the cost of research and/or development activities or other activities performed or to be performed by Borrower or expended
or to be expended by Borrower with respect to the Designated Products.

 

“Designated Products”
means shall be the first two new products to be acquired by Borrower following the closing of the Acquisition Financing Loans transaction;
provided that one of such products is "Myoconda" for the treatment of Crohn’s disease. In the event that Myoconda
is not acquired as one of these first two new products, Designated Products shall mean the first two currently existing Borrower
products (i.e., RHB-101 (cardio), RHB-102 (anti-emesis), and RHB-103 (migraine) to have a commercial sale.

 

Payment. Royalty shall be due and
payable on a calendar quarterly basis within sixty (60) days following the end of each applicable quarter, against the receipt
of an appropriate invoice from Lender for same. In the event such payment may require approval of any governmental authority, Borrower
undertakes to promptly file for approval and to effectuate payment promptly following receipt of the necessary approval

 

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Reports. With respect to each Royalty
payment, Borrower shall deliver to Lender a report with respect to the period covered by the Royalty payment on a calendar quarterly
basis within thirty (30) days following the end of each March, June, September and December reporting the amount of Net Sales and
Sublicense Revenues received from Designated Products, including the Recognized Deductions applicable in computing Net Sales and
the deductions applicable in computing Sublicense Revenues, and the total Royalties due based on Net Sales and Sublicense Revenues.

 

Payment Method. Any amounts due
to Lender under this Agreement will be paid in U.S. dollars, by wire transfer in immediately available funds to an account designated
in writing in an appropriate invoice at least fifteen (15) days in advance by Lender.

 

Currency; Foreign Payments. If any
currency conversion will be required in connection with the calculation of any payment hereunder, such conversion will be made
by using the exchange rate for the purchase of U.S. dollars as published in The Wall Street Journal, Eastern Edition, on
the date of the payment. If at any time legal restrictions prevent the prompt remittance of any payments in any jurisdiction, Borrower
may notify Lender and make such payments by depositing the amount thereof in local currency in a bank account or other depository
in such country in the name of Lender or its designee, and Borrower will have no further obligations under this Agreement with
respect thereto.

 

Taxes. Royalty amounts are
gross amounts and Lender shall be responsible for all taxes thereon. Borrower may deduct from amounts it is required to pay Lender
pursuant to this Agreement an amount equal to that required by applicable law to be withheld by Borrower for or due on account
of any taxes (including VAT to the extent applicable, but other than taxes imposed on or measured by net income of Borrower) or
similar governmental charge imposed by any jurisdiction based on such payments to Lender (“Withholding Taxes”)
and such payment shall be deemed as payment to Lender in accordance with this Agreement. Borrower will provide Lender a certificate
evidencing payment of any Withholding Taxes.

 

Record Retention. Until the
expiry of the Royalty Term, Borrower will maintain (and will ensure that its affiliates maintain) complete and accurate
books, records and accounts that fairly reflect Net Sales and Sublicense Revenues, in sufficient detail to confirm the accuracy
of any payments required hereunder, which books, records and accounts will be retained for two (2) years after the end of the period
to which such books, records and accounts pertain.

 

Audit. Lender will have the
right, at its own cost, to have an independent certified public accounting firm of nationally recognized standing, reasonably acceptable
to Borrower and who agrees to be bound by a customary undertaking of confidentiality, have access during normal business hours,
and upon reasonable prior written notice, to Borrower’s records as may be reasonably necessary to verify Borrower’s
compliance with the terms of this Agreement, including without limitation the accuracy of Net Sales and Sublicense Revenues, as
applicable, for any period ending not more than twenty –four (24) months prior to the date of such request; provided, however,
that Lender will not have the right to conduct more than one such audit in any calendar year or more than one such audit covering
any given time period. The auditing firm will disclose to Lender only the results of its audit and not any other information. Any
such audit shall be made during Borrower’s normal business hours and shall not unreasonably interfere with the business of
Borrower and shall be completed within a reasonable time. Lender will bear all the costs of such audit. Without derogating from
the forgoing, Lender's audit rights shall be conducted no later than two years following the final payment under this Agreement.
The costs of the audit are the responsibility of Lender except in the event there is shortfall of more than 10% in the payment
due; in which case the audit costs and all related travel costs up to a maximum amount of US $50,000 will be covered by Borrower
within thirty (30) days of billing.

 

    	14

    	 

    

 

Confidentiality. Lender will treat
all information subject to review hereunder in strict confidence.

 

Continuing Right. The right to receive
Royalties on the terms stated herein will continue without regard to any conversion or repayment of the Loan and shall not be appurtenant
or incidental to any securities issued on conversion of the Loan.

 

    	15Exhibit 4.10

 

THE SECURITIES REPRESENTED HEREBY HAVE
NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “1933 ACT”), THE ISRAELI
SECURITIES LAW OF 1968 (THE “SECURITIES LAW”) OR ANY APPLICABLE STATE SECURITIES LAWS. IN THE ABSENCE OF AN
EFFECTIVE REGISTRATION STATEMENT UNDER THE 1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS, THESE SECURITIES MAY NOT BE OFFERED,
SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE
1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS.

 

Terms
of Convertible Loan 

 

These Terms of Convertible Loan detail
the terms of the Convertible Loan into which an Acquisition Financing Loan made by certain Lenders to Borrower was converted pursuant
the terms of the Loan Agreement in respect of such Acquisition Financing Loan.

 

 

1.          Definitions.

 

“Borrower”
- RedHill Biopharma Ltd.

 

“Convertible Financing Lenders”-       all
lenders, including Lender, providing convertible loans to Borrower on terms similar to those of these Terms of convertible Loan.

 

“Loan”
-        The amount of the Acquisition Financing Loan converted into the loan described herein.

 

“Lender” -     The
maker of the Acquisition Financing Loan. 

 

2.        Interest.
The Loan shall bear interest on its outstanding principal amount in US Dollars, at a per annum rate equal to eight percent (8.0%),
compounded annually (“Interest”). Interest shall accrue and not be payable until the Loan is converted
pursuant to the provisions of Section 4 below. The principal amount of the Loan together with accrued Interest is hereinafter referred
as the “Loan Amount”.

 

3.        Use
of Proceeds. Borrower undertakes that the entire amount of the Loan shall be used to fund Borrower’s, acquisition
of products, research and development activities and general working capital.

 

4.        Mandatory
Conversion. 

 

		(a)	Unless previously converted, in the event that at any time following the funding of the Loan hereunder
and prior to December 31, 2011, Borrower shall close an equity investment, or series of related equity investments, in a minimum
aggregate amount of Three Million US Dollars ($3,000,000) (excluding conversion of the Loan) (the “Financing Round”),
the entire outstanding Loan Amount shall automatically convert into shares of the class of equity securities of Borrower issued
in the Financing Round on the same terms as the Financing Round but at a price per share which shall be equal to seventy percent
(70%) of the price per share paid by the investors in the Financing Round (the “Lender Price Per Share”)
and Borrower shall issue to Lender the number of shares of the class of equity securities issued in the Financing Round ("Financing
Conversion Shares") as is obtained by dividing (i) the outstanding Loan Amount as of the closing date of the Financing
Round by (ii) the Lender Price Per Share. In the event that the Financing Round is achieved through a series of equity financings
and the transactions consummated in such equity financings are not on identical terms and conditions or involve the issuance of
more than one type of securities, then Lender shall be entitled to the most favorable class or series of equity securities issued
in such financing and/or the most favorable terms and conditions.

 

    	 

    	 

    

 

		(b)	Unless previously converted, on December 31, 2011 the Loan Amount shall be automatically converted
into the class of equity securities of Borrower having the most seniority in terms of distribution of assets upon liquidation,
outstanding at such time (the “Senior Conversion Shares”), at a price per share reflecting a pre-money
valuation of Borrower (on a fully-diluted basis) of Seven Million US Dollars ($7,000,000) and Borrower shall issue to Lender the
number of Senior Conversion Shares determined by dividing the outstanding Loan Amount by the product of (i) Seven Million US Dollars
($7,000,000) divided by (ii) the aggregate number of issued and outstanding shares of equity securities of Borrower, on a fully-diluted
and as-converted basis.

 

		(c)	Unless previously converted, immediately prior to the consummation
of: (i) a consolidation or merger of Borrower with or into any person (other than an affiliate of Borrower) or
pursuant to which the outstanding equity of Borrower is converted into cash, securities or other property, in each case
other than a transaction in which the shareholders of Borrower prior to the transaction will hold
more than 50% of the voting securities (on an as-converted basis) of the surviving entity after the transaction; (ii)
a sale or other disposition of all or substantially all of Borrower’s assets to any person, other than an affiliate of Borrower;
or (iii) a transaction in which any person or related group (other than Borrower and/or its affiliates) acquires more than fifty
percent (50%) of the issued and outstanding shares, or more than fifty percent (50%) of the outstanding voting power of Borrower;
(each of the transactions in clauses (i)-(iii), a “Change in Control Transaction”), then immediately
prior to the closing or effectiveness of the Change in Control Transaction the outstanding Loan Amount shall be converted into
Ordinary Shares of Borrower (the “Change in Control Conversion Shares”) at a price per share equal to
70% of the price per share in the Change in Control Transaction determined as follows: (A) in respect of a Change in Control Transaction
described in clause (c)(i) above, the price per share shall be the aggregate consideration actually to be distributed to and received
by the shareholders of Borrower in the Change in Control Transaction, divided by the aggregate number of issued and outstanding
shares of equity securities of Borrower, on a fully-diluted and as-converted basis, participating in such distribution; (B) in
respect of a Change in Control Transaction described in clause (c)(ii) above, the price per share shall be the aggregate consideration
available for distribution to the holders of the equity securities of Borrower as a result of the Change in Control Transaction,
as determined by the board of directors of Borrower, divided by the aggregate number of issued and outstanding equity securities
of Borrower, on a fully diluted and as-converted basis, eligible to participate in such distribution and (C) in respect of a Change
in Control Transaction described in clause (c)(iii) above the price per share shall be the price per share in such Change in Control
Transaction. The value of securities or other payments-in-kind, if any, distributed to the holders of shares shall be determined
by the board of directors of Borrower, in its sole discretion.

 

    	2

    	 

    

 

		(d)	Unless previously converted, immediately prior to the consummation
of an initial public offering by Borrower of its shares pursuant to an effective registration statement, prospectus or similar
document under the US Securities Act of 1933, as amended, under the Israeli Securities Law of 1968
or any equivalent law of another jurisdiction (“IPO”), the outstanding Loan Amount shall be converted
into Ordinary Shares of Borrower (the “IPO Conversion Shares”) at a price per share equal to 70% of the
price per share in the IPO (for the avoidance of doubt, it is hereby clarified that in the event the IPO is conducted on the Tel-Aviv
Stock Exchange (“TASE”) the outstanding Loan Amount shall be converted into Ordinary Shares of Borrower
at a price per share equal to 70% of the minimum price per share determined in the Company's Prospectus (including any complimentary
notice, as applicable). In the event that that the securities of Borrower offered in the IPO consist of “units” comprising
Ordinary Shares and other securities, then the price per share in the IPO shall be the effective price per share as part of the
unit as published in the Company's Prospectus or as determined by the board of directors of the Company. For the avoidance of doubt,
it is hereby clarified that in the event the IPO is conducted on the TASE, the effective price per share shall be calculated in
accordance with the TASE's rules and regulations. In any other event the effective price per share shall be calculated based on
the Black-Scholes model. 

 

		(e)	In the event that the Lender Price Per Share, the price per share in a Change in Control Transaction
or the price per share in an IPO is expressed in any currency other than US Dollars, conversion of the Loan Amount shall be in
accordance with the rate of exchange last published by the Bank of Israel and known at the time of consummation of the relevant
transaction and in the event of an IPO on the TASE on the date of publication of the Company's Prospectus.

 

		(f)	Lender acknowledges and agrees that in the event of a public offering of the Company’s securities
any securities issued to Lender upon conversion of the Loan Amount may be subject to a lock-up period.

 

		(g)	It is agreed that in no event shall the price per share paid by Lender for the shares upon conversion
in accordance with this Section 4 (the “Conversion Price Per Share”) exceed a price per share reflecting
a pre-money valuation of Borrower (on a fully-diluted basis) of Twelve Million US Dollars ($12,000,000).

 

		(h)	Upon conversion of the Loan Amount as aforesaid, the Loan and all Interest accrued thereon shall
be deemed fully repaid, and the issuance of the Financing Conversion Shares, Change in Control Conversion Shares, IPO Conversion
Shares or the Senior Conversion Shares, as the case may be, shall be deemed as full and complete satisfaction of all Borrower’s
obligations under this Agreement and Lender shall have no further rights under this Agreement or with respect to the Loan and Interest
accrued thereon.

 

		(i)	For the avoidance of doubt, it is hereby expressly agreed that each of the conversion events described
in paragraphs (a) through (d) this Section 4 is independent of each other such event and the Loan Amount shall be subject to conversion
upon achievement of the conditions set forth in any of such paragraphs.

 

5.        Grant
of Warrant. Upon conversion of the Loan Amount, Borrower shall grant Lender a warrant substantially in the form of the
Warrant Certificate attached hereto as Exhibit A (the “Warrant”) to purchase additional
Financing Conversion Shares, Change in Control Conversion Shares, IPO Conversion Shares or Senior Conversion Shares, as the case
may be.

 

6.        Default.
The entire Loan Amount will immediately become due and payable upon any of the following events of
default:

 

    	3

    	 

    

 

		(a)	the commencement by Borrower of any liquidation proceedings or the adoption of a winding up resolution
by Borrower, or the appointment of a receiver or trustee over the whole or a substantial part or Borrower's assets, or the calling
by Borrower of a meeting of creditors for the purpose of entering into a scheme or arrangement with them, and if any of the aforementioned
actions or proceedings is not canceled within 60 days of its initiation; or

 

		(b)	the levy of an attachment or the institution of execution proceedings against the whole or a substantial
part of Borrower's assets, where such attachment or execution proceeding is not discharged within sixty (60) days. Borrower shall
notify Lender within 72 hours of any such attachment or proceeding.

 

7.        Confidentiality.
Lender undertakes that all information concerning Borrower, which comes into its possession or to
its attention, whether pursuant to this Agreement, as a shareholder of Borrower or otherwise, including audited and unaudited financial
statements of Borrower, and all other financial, technical and other information relating to Borrower, will be kept in the strictest
confidence and will not, without the prior written consent of Borrower, be used by it or be disclosed to, or discussed with, any
third party provided, however, in the event that Lender is required by law or stock exchange rule to include financial information
obtained pursuant to this Agreement in reports to governmental authorities or stock exchanges, Lender shall be entitled to make
such disclosure to the minimum extent required, and provided, further, that in connection with periodic reports to Lender's shareholders
or partners, Lender may, without first obtaining the prior written consent of Borrower, make general statements, not containing
technical, commercially sensitive or other confidential information, regarding the general nature of Borrower, and may provide
summary and general information regarding Borrower’s revenues and profits to Lender's lawyers and accountants, and in its
reports to its shareholders and partners, but may not annex to such reports the full financial information to be provided by Borrower
hereunder except as required by applicable law and regulations. Notwithstanding the above, the undertaking of confidentiality will
not apply to:

 

(i)        Information
which is in the public domain at the time of disclosure or subsequently becomes part of the public domain, except by breach by
a party hereto of its obligations hereunder; or

 

(ii)       Information
which is received from a third party, provided that such information was not obtained by said third party directly or indirectly
from Borrower pursuant to obligations of confidentiality; or

 

(iii)      Information
which must be disclosed under applicable laws or regulations but only to the extent so required; provided, however, that in the
event a party feels that circumstances exist which require such disclosure, it shall notify Borrower thereof, and provide Borrower
with a copy of such proposed disclosure or notice, promptly and, where possible, in a manner which will enable Borrower to oppose
such disclosure within the period of time allotted under such laws or regulations for submission of the disclosure or notice.

 

8.        Governing
Law and Forum. These Terms of Convertible Loan, their interpretation, validity and breach shall be governed by the laws
of the State of Israel, without regard to its conflict of laws rules, and any claim or dispute with respect thereto shall be submitted
to the exclusive jurisdiction of the competent courts of Tel-Aviv, Israel, and each of Borrower and Lender hereby submits irrevocably
to the jurisdiction of such court to the exclusion of any other jurisdiction and agrees to the service of process by post in accordance
with the provisions of Section 11(i) below.

 

    	4

    	 

    

 

9.        MiscellaneoUS

 

(a)          Further
Cooperation. Each of Borrower and Lender agree to execute any and all documents necessary in order to consummate, implement
and give full force and effect to this Agreement, and to all matters, actions and transactions envisaged and contemplated herein
including, filings with governmental or regulatory bodies, corporate resolutions and such other documentation as may be reasonably
necessary from time to time.

 

(b)          No Partnership.
Each of Borrower and Lender are independent contractors. There is no relationship of partnership, joint venture, employment, franchise
or agency between Borrower and Lender. Neither of Borrower or Lender will have the power to bind the other or incur obligations
on the other's behalf without the other's prior written consent.

 

(c)          Construction.
A reference to a Section, Exhibit or Schedule shall mean a Section in or Exhibit or Schedule to these Terms of Convertible Loan,
unless otherwise expressly stated. The titles and headings herein are for reference purposes only and shall not have any significance
in the interpretation of these Terms of Convertible Loan nor in any manner limit the construction of these Terms of Convertible
Loan which shall be considered as a whole. The words “include,” “includes” and “including”
when used herein shall be deemed in each case to be followed by the words “without limitation.” Whenever the context
may require, any pronouns used herein shall include the corresponding masculine, feminine or neuter forms, and the singular form
of names and pronouns shall include the plural and vice-versa. The plural of any defined term shall have a meaning correlative
to such defined term and words denoting any gender shall include all genders and the neuter. Where a word or phrase is defined
herein, each of its other grammatical forms shall have a corresponding meaning. Each of Borrower and Lender have participated jointly
in the negotiation and drafting of these Terms of Convertible Loan. If any ambiguity or question of intent or interpretation arises,
these Terms of Convertible Loan shall be construed as if drafted jointly by the parties, and no presumption or burden of proof
shall arise favoring or disfavoring any party by virtue of the authorship of any provision of these Terms of Convertible Loan.

 

(d)          Successors
and Assigns. Except as otherwise provided herein, the terms and conditions of these Terms of Convertible Loan shall inure to
the benefit of and be binding upon the respective successors and assigns of Borrower and Lender. Nothing in these Terms of Convertible
Loan, express or implied, is intended to confer upon any party other than Borrower and Lender or their respective successors and
assigns, any rights, remedies, obligations, or liabilities under or by reason of these Terms of Convertible Loan, except as expressly
provided herein.

 

(e)          None of the
rights, privileges, or obligations set forth in, arising under, or created by these Terms of Convertible Loan may be assigned without
the prior consent in writing of Borrower and Lender, with the exception of: (a) assignments between Convertible Financing Lenders,
and (b) assignments from Lender to any other entity which controls, is controlled by or is under common control with, Lender; provided,
however, that no such assignment or transfer shall become effective unless each such transferee has provided Borrower with a confirmation
in writing that it is bound by all terms and conditions of this Agreement and all the agreements contemplated hereby.

 

(f)          Severability.
If one or more provisions of these Terms of Convertible Loanis held to be illegal, invalid or unenforceable under applicable law,
such provision shall be excluded from these Terms of Convertible Loan, and the balance of these Terms of Convertible Loan shall
be interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms; provided, however,
that in such event these Terms of Convertible Loan shall be interpreted so as to give effect, to the greatest extent consistent
with and permitted by applicable law, to the meaning and intention of the excluded provision as determined by such court of competent
jurisdiction.

 

    	5

    	 

    

 

(g)          Waivers.
The failure of Borrower or Lender at any time or times to require performance of any provision hereof or to enforce any right with
respect thereto, shall in no manner affect the right of such party at a later time to enforce the same and shall in no way be construed
to be a waiver of such provision or right.

 

(h)          Entire
Agreement; Amendments. These Terms of Convertible Loan and the exhibits attached hereto constitute the full and entire understanding
and agreement among Borrower and Lender with regard to the subjects hereof and thereof, and no previous agreements, memoranda of
agreements, letters, negotiations, promises, consents, undertakings, representations, warranties or documents which were applied,
exchanged, or signed by or between Borrower and Lender prior to these Terms of Convertible Loan shall have any force or effect.
Any term of these Terms of Convertible Loan may be amended and the observance of any term of this Agreement may be waived (either
generally or in a particular instance and either retroactively or prospectively) in the context of a similar amendment or waiver
in respect of the Conversions Lender Loans, with the written consent of Borrower and Conversion Financing Lenders who have provided
a majority of the outstanding aggregate total amount provided as Conversion Lender Loans.

 

(i)          Notices.
All notices and other communications required or permitted hereunder shall be in writing, shall be effective when given, and shall
in any event be deemed to be given upon receipt or, if earlier, (a) five (5) business days after the business day of deposit
with an express courier, freight prepaid, (b) upon delivery, if delivered by hand; or (c) one (1) business day after
the business day of facsimile transmission or e-mail, if delivered by facsimile transmission or sent by e-mail. All such notices
and other communications shall be addressed to the following addresses or such other address as the recipient party may designate
by ten (10) days advance written notice to the other party pursuant to the provisions above:

 

If
to Lender, as set forth on the signature page of the Loan Agreement between Borrower and Lender regarding an Acquisition Financing
Loan.

 

If
to Borrower:

 

RedHill
Biopharma Ltd.

42
Givati Street

Ramat-Gan
52232, Israel

Fax:
972-3-7255723

Email:
ori@redhillbio.com

Attn:
Ori Shilo

 

(j)          Publicity. Lender shall
not, subject to the requirements or law, regulations or order, issue any press release or undertake any publicity concerning the
existence or any of the terms or provisions of these Terms of Convertible Loan or any of the transactions contemplated hereby or
thereby without the prior written consent of Borrower.

 

(k)          Fees and Expenses. Lender
and Borrower shall each bear their own expenses and legal fees incurred by them or on their behalf with respect to ”and the
transactions contemplated hereby.

 

Date: August 31, 2010

 

*                   *                 *

 

    	6

    	 

    

 

Exhibit
A

 

Warrant Certificate

 

THE WARRANT AND THE SECURITIES ISSUABLE
UPON THE EXERCISE OF THIS WAARANT HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “1933
ACT”), THE ISRAELI SECURITIES LAW OF 1968 (THE “SECURITIES LAW”) OR ANY APPLICABLE STATE SECURITIES
LAWS. IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE 1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS, THESE SECURITIES
MAY NOT BE OFFERED, SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO AN APPLICABLE EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF THE 1933 ACT, THE SECURITIES LAW AND SUCH STATE LAWS.

 

WARRANT TO PURCHASE SHARES

 

RedHill Biopharma Ltd., an Israeli company
(the “Company”), hereby grants to _________________________ (the “Holder”), the right to
purchase from the Company such number and class of shares of the Company, set forth below, subject to the terms and conditions
set forth below. The parties acknowledge that this Warrant is granted in connection with the conversion of a loan extended by Holder
to the Company pursuant to the terms and conditions of that certain Terms of Convertible Loan dated August 31, 2010 (the “Loan”
and the “Loan Agreement”, respectively). Unless otherwise required by the context, all capitalized terms used
herein and not otherwise defined shall have the respective meanings ascribed to them in the Loan Agreement.

 

		1.	Number of Shares Available for Purchase and Exercise
Price

 

This Warrant may be exercised
to purchase up to that number of shares of the Company of the class determined as provided below (the “Warrant Shares”)
equal to $[ ],000, which is equal to thirty percent (30%) of the original principal amount of the Loan (without any interest or
linkage), divided by the Warrant Price (as defined below). For the purposes of this Warrant, the class of shares comprising the
Warrant Shares shall be the class comprising the Financing Conversion Shares, Change in Control Conversion Shares, IPO Conversion
Shares or Senior Conversion Shares (as such terms are defined in the Loan Agreement), as the case may be, issued to the Holder
in connection with the conversion of the Loan and shall be referred to as the “Conversion Class of Shares”.
Notwithstanding the foregoing, from and after immediately prior to the consummation of an IPO (as defined in the Loan Agreement),
the outstanding Conversion Class of Shares shall be Ordinary Shares of the Company.

 

    	7

    	 

    

 

The exercise price for
each Warrant Share (the “Warrant Price”) shall be calculated as follows: (i) in the event Holder exercises this
Warrant within six (6) months following the Conversion Event (as such term is defined in Section 5 of the Loan Agreement) (the
“Initial Exercise Period”), the Warrant Price shall be equal to 130% of the Conversion Price Per Share (as defined
in the Loan Agreement) at which the Loan was converted in the Conversion Event; (ii) in the event Holder exercises this Warrant
within six (6) months following the end of the Initial Exercise Period (the “Second Exercise Period”), the Exercise
Price shall be equal to 140% of the Conversion Price Per Share at which the Loan was converted in the Conversion Event; and (iii)
in the event Holder exercises the Warrant following the end of the Second Exercise Period, the Exercise Price shall be equal to
150% of the Conversion Price Per Share at which the Loan was converted in the Conversion Event.

 

		2.	Term

 

This Warrant may be exercised,
in whole, or in part (subject to Section 4 below), during the period beginning on the date of the Conversion Event and ending on
the earlier to occur of: (a) thirty-six (36) months following the date of closing under the Loan Agreement or (b) a Change in Control
Transaction (as defined in the Loan Agreement) (the “Exercise Period”).

 

		3.	Exercise of Warrant

 

This Warrant may be exercised
in whole or in part on any number of occasions during the Exercise Period. The Warrant may be exercised by the surrender of the
Warrant to the Company at its principal office together with the Notice of Exercise annexed hereto duly completed and executed
on behalf of the Holder. This Warrant may be exercised for cash only. To exercise, the Notice of Exercise must be accompanied by
payment in full of the amount of the aggregate Warrant Price payable for the Warrant Shares being purchased upon such exercise
in immediately available funds, in U.S. Dollars or NIS equivalent thereof, based on the representative rate of exchange last published
by the Bank of Israel and known at the time of payment.

 

The Company agrees that the Warrant Shares
so purchased shall be issued as soon as practicable thereafter, and that the Holder shall be deemed the record owner of such Warrant
Shares as of and from the close of business on the date on which this Warrant shall be surrendered, together with payment in full
as required above. In the event of a partial exercise, the Company shall concurrently issue to the Holder a replacement Warrant
on the same terms and conditions as this Warrant, but representing the number of Warrant Shares remaining after such partial exercise.

 

		4.	Fractional Shares

 

No fractional shares
will be issued in connection with any exercise hereunder, and the number of Warrant Shares issued shall be rounded down to the
nearest whole number.

 

    	8

    	 

    

 

		5.	Warrant Confers No Rights of Shareholder

 

Except as otherwise set
forth in this Warrant, the Holder shall not have any rights as a shareholder of the Company with regard to the Warrant Shares prior
to actual exercise of this Warrant resulting in the purchase of Warrant Shares and the issuance of such shares.

 

		6.	Investment Representation

 

Neither this Warrant
nor the Warrant Shares issuable upon the exercise of this Warrant have been, as of the date hereof, registered under the 1933 Act,
the Securities Law or any other securities laws. The Holder agrees that any Warrant Shares issuable upon exercise of this Warrant
will be acquired for investment and not with a view to distribution and such Warrant Shares will not be registered under the Securities
Act, the Securities Act or any applicable state securities laws and that such Warrant Shares may have to be held indefinitely unless
they are subsequently registered or qualified under the 1933 Act, the Securities Law and applicable state or foreign securities
laws, or based on an opinion of counsel reasonably satisfactory to the Company that an exemption from such registration and qualification
is available. The Holder, by acceptance hereof, consents to the placement of legend(s) on all securities hereunder as to the applicable
restrictions on transferability in order to ensure compliance with the 1933 Act and the Securities Law, unless in the opinion of
counsel for the Company such legend is not required in order to ensure compliance with the 1933 Act and the Securities Law. The
Company may issue stop transfer instructions to its transfer agent in connection with such restrictions. Adjustment of Warrant
Price and Number of Shares

 

		7.	Adjustment.

 

The
number and kind of securities purchasable initially upon the exercise of this Warrant and the Warrant Price shall be subject to
adjustment from time to time upon the occurrence of certain events during the Exercise Period, as follows:

 

		a.	Adjustment for Shares Splits and Combinations.
If the Company at any time or from time to time during the Exercise Period effects a subdivision of the Conversion Class of Shares,
the number of shares issuable upon exercise of this Warrant immediately before the subdivision shall be proportionately increased
and conversely, if the Company at any time or from time to time combines the outstanding Conversion Class of Shares, the number
of shares issuable upon exercise of this Warrant immediately before the combination shall be proportionately decreased. Any adjustment
under this Section 7(a) shall become effective at the close of business on the date the subdivision or combination becomes effective.

 

    	9

    	 

    

 

		b.	Adjustment for Reclassification, Exchange and Substitution.
If the shares of the Conversion Class of Shares issuable upon the exercise of this Warrant are changed into the same or a different
number of shares of any class or classes of shares, whether by recapitalization, conversion, reclassification or otherwise (other
than a subdivision or combination of shares or shares dividend or a reorganization, merger, consolidation or sale of assets,
provided for elsewhere in this Section), then and in any such event the Holder shall have the right thereafter to exercise this
Warrant into the kind and amount of shares and other securities receivable upon such recapitalization, reclassification or other
change, by holders of the number of shares of the Conversion Class of Shares for which this Warrant might have been exercised
immediately prior to such recapitalization, reclassification or change, all subject to further adjustment as provided herein and
under the Company’s Articles of Association.

 

		c.	Reorganization Mergers, Consolidations or Sales
of Assets. If at any time or from time to time during the Exercise Period there is a capital reorganization of the Conversion
Class of Shares (other than a recapitalization, subdivision, combination, reclassification or exchange of shares provided for
elsewhere in this Subsection), or a merger or consolidation of the Company with or into another corporation, or the sale of all
or substantially all of the Company’s shares or properties and assets to any other person, then, as a part of such reorganization,
merger, consolidation or sale, then, as a part of such reorganization, provision shall be made so that the Holder shall thereafter
be entitled to receive upon exercise of this Warrant, the number of shares or other securities or property of the Company, or
of the successor corporation resulting from such merger or consolidation or sale to which a holder of the shares of the Conversion
Class of Shares deliverable upon conversion would have been entitled on such capital reorganization merger, consolidation or sale.
In any such case (except to the extent any cash or property is received in such transaction), appropriate adjustment shall be
made in the application of the provisions of this Subsection and the Company’s Articles of Association with respect to the
rights of the Holder after the reorganization merger, consolidation or sale to the end that the provisions of this Subsection
and the Company’s Articles of Association (including adjustment of the number of shares of the Conversion Class of Shares
issuable upon exercise of this Warrant) shall be applicable after that event and be as nearly equivalent to the provisions hereof
as may be practicable.

 

		d.	Adjustment of Warrant Price. Upon each
relevant adjustment in the number of the Conversion Class of Shares purchasable hereunder, the Warrant Price shall be proportionately
increased or decreased, as the case may be, in a manner that is the inverse of the manner in which the number of the Conversion
Class of Shares purchasable hereunder shall be adjusted.

 

    	10

    	 

    

 

		e.	Notice of Adjustments. Whenever the Warrant
Price or the number of Warrant Shares purchasable hereunder shall be adjusted pursuant to this Section 7, the Company shall provide
the Holder with a certificate setting forth, in reasonable detail, the event requiring the adjustment, the amount of the adjustment,
the method by which such adjustment was calculated, and the Warrant Price and the number of Warrant Shares purchasable hereunder
after giving effect to such adjustment.

 

		8.	Transfer

 

The
transfer of this Warrant shall be restricted in the same manner as the transfer of shares of the Conversion Class of Shares is
restricted by the provisions of the Articles of Association. Without derogating from the foregoing, following the initial public
offering of the shares of the Company, the transfer of this Warrant shall be subject to the prior written approval of the Company's
board of directors. In the event of a public offering of the Company’s securities the Warrant Shares issued to the Holder
upon exercise of this Warrant may be subject to a lock-up period along with the other shareholders of the Company. 

 

		9.	Representations
                                                                                                                                                                             and
                                                                                                                                                                             Warranties.

 

The Company
represents and warrants to the Holder as follows:

 

		a.	This Warrant has been duly authorized and executed by
the Company and is a valid and binding obligation of the Company enforceable in accordance with its terms.

 

		b.	Subject to the creation of the Conversion Class of Shares, the Warrant Shares shall be duly authorized
and reserved for issuance by the Company and, when issued in accordance with the terms hereof, will be validly issued, fully paid
and nonassessable and not subject to any preemptive rights.

 

		c.	Subject to the creation of the Conversion Class of Shares, the execution and delivery of this Warrant
are not, and the issuance of the Warrant Shares upon exercise of this Warrant in accordance with the terms hereof will not be,
inconsistent with the Company’s Articles of Association.

 

    	11

    	 

    

 

		10.	Loss,
                                                                                                                                                                              Theft,
                                                                                                                                                                              Destruction
                                                                                                                                                                              or
                                                                                                                                                                              Mutilation
                                                                                                                                                                              of
                                                                                                                                                                              Warrant

 

Upon receipt
by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of any Warrant or Shares
certificate, and in case of loss, theft or destruction, of indemnity, or security reasonably satisfactory to it, and upon reimbursement
to the Company of all reasonable expenses incidental thereto, and upon surrender and cancellation of such Warrant or Shares certificate,
if mutilated, the Company will make and deliver a new Warrant or Shares certificate of like tenor and dated as of such cancellation,
in lieu of such Warrant or Shares certificate.

 

		11.	Tax
                                                                                                                                                                              

 

Any
tax arising with respect to the grant or exercise of the Warrant, the payment for, or disposition of the Warrant Shares covered
thereby, or from any other event or act in connection therewith, shall be borne solely by the Holder. The Company shall be entitled
to withhold taxes according to the requirements of any applicable laws, rules, and regulations, including withholding taxes at
source. The Holder shall indemnify the Company and hold the Company harmless against and from any and all liability for any such
tax or interest or penalty thereon.

 

		12.	Notices

 

Any notice
or other communication hereunder shall be in writing and shall be deemed to have been given upon delivery, if personally delivered
or three (3) business days (five (5) business days if sent internationally) after deposit if deposited in the mail for mailing
by registered or certified mail (airmail if sent internationally), postage prepaid, and addressed as follows:

 

			If to Holder:

 

			

 

			To the address set forth on the signature page hereto

 

			

 

If
to Company:

 

42 Givati
Street

Ramat-Gan
52232, Israel

Tel:
972-3-6761706

Fax:
972-3-7255723

Email:
ori@redhillbio.com

Attn:
Ori Shilo

 

    	12

    	 

    

 

			

 

Each of the
above addressees may change its address for purposes of this paragraph by giving to the other addressees notice of such new address
in conformance with this paragraph.

 

		13.	Applicable Law; Jurisdiction

 

This Warrant
shall be governed by and construed in accordance with the laws of the State of Israel as applicable to contracts between two residents
of the State of Israel entered into and to be performed entirely within the State of Israel. Any dispute arising under or in relation
to this Warrant shall be resolved exclusively in the competent court for Tel Aviv-Jaffa district, and each of the parties hereby
submits irrevocably to the exclusive jurisdiction of such court.

 

		14.	Entire Agreement

 

This Warrant
constitutes the entire agreement between the parties hereto with regard to the subject matters hereof, and supersedes any prior
communications, agreements and/or understandings between the parties hereto with regard to the subject matters hereof.

 

[Remainder of page intentionally left
blank]

 

    	13

    	 

    

 

IN WITNESS WHEREOF, the Company has executed
this Warrant Certificate as of the date set forth below.

 

Dated: August 31 2010

 

RedHill Biopharma Ltd. 

 

	By:	 	 
	Name: 	Ori Shilo	 
	Title: 	VP Finance	 
	 	 
	Agreed and accepted:	 
	 	 
	Holder	 
	 	 
	By:	 	 
	Name:	 	 
	Title:	 	 

 

Address

 

    	14

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