Document:

Amendment No. 4 to the Amended and Restated Credit and Security Agreement

 Exhibit 10.2 
 AMENDMENT NO. 4 TO AMENDED AND RESTATED 
 CREDIT AND SECURITY AGREEMENT

 This Amendment No. 4 to Amended and Restated Credit and Security Agreement (this “Amendment”),
dated as of October 11, 2011, is entered into by and among PACKAGING RECEIVABLES COMPANY, LLC, a Delaware limited liability company, as borrower (together with its successors and permitted assigns, the “Borrower”),
PACKAGING CREDIT COMPANY, LLC, a Delaware limited liability company, as initial servicer (together with its successors, the “Servicer”), PACKAGING CORPORATION OF AMERICA, a Delaware corporation, as performance
guarantor (the “Performance Guarantor”), BANK OF AMERICA, NATIONAL ASSOCIATION, as lender (in such capacity, the “Lender”), and as agent for the Lender (in such capacity, the “Agent”).

 RECITALS 
 WHEREAS, the parties hereto have entered into that certain Amended and Restated Credit and Security Agreement dated as of September 19, 2008 (as amended by that certain Amendment No. 1 to
Amended and Restated Credit and Security Agreement dated as of April 15, 2009, that certain Amendment No. 2 to Amended and Restated Credit and Security Agreement dated as of April 14, 2010, and that certain Amendment No. 3 to
Amended and Restated Credit and Security Agreement dated as of March 1, 2011, and as otherwise amended, supplemented or otherwise modified through the date hereof, the “Credit Agreement”); 

WHEREAS, the Performance Guarantor has provided the Performance Guarantee (as amended, supplemented or otherwise modified through the
date hereof, as so amended, the “PCA Performance Guarantee”) to the Agent for the benefit of the Persons named therein in relation to the obligations of the Servicer under the Transaction Documents; 

WHEREAS, the parties hereto wish to make certain changes to the Credit Agreement as herein provided and the Performance Guarantor desires
to ratify the PCA Performance Guarantee; 
 NOW, THEREFORE, in consideration of the premises and the mutual agreements contained
herein and in the Credit Agreement, the sufficiency of which is hereby acknowledged, the parties hereto agree as follows: 

SECTION 1. Definitions. All capitalized terms not otherwise defined herein are used as defined in (or by reference in) the Credit
Agreement. 

 SECTION 2. Amendments to the Credit Agreement. 

2.1. Section 10.1(j) of the Credit Agreement is hereby amended and restated in its entirety to read as follows: 

“(j) as of the last day of each fiscal quarter, (i) a ratio of (x) Consolidated Funded Debt minus unrestricted cash
on hand of Packaging Corporation of America and its U.S. Subsidiaries (other than the Receivables 
 Subsidiaries) in excess of
$50,000,000 in the aggregate to (y) Consolidated EBITDA for the four quarter period then ended exceeds 3.5:1, or (ii) a ratio of Consolidated EBITDA as at the end of each quarter for the four quarter period then ended of Packaging
Corporation of America and its Subsidiaries to the sum of interest payable on, and amortization of debt discount in respect of, all Debt during such period, in each case, by Packaging Corporation of America and its Subsidiaries is less than 3.5:1
(it being understood and agreed that, for the avoidance of doubt, for purposes of this clause (j), the capitalized terms used herein shall have the meanings set forth in the Five Year Credit Agreement without giving any effect to any
amendment, modification or supplement thereto executed after October 11, 2011 or any termination thereof); or”. 

2.2. The “Initial Commitment” as set forth on the Lender’s signature page to the Credit Agreement is hereby amended and
restated in its entirety to read as follows: “Commitment: $200,000,000”. 
 2.3. Clause (a)(i) of the
definition of “Dilution Reserve” in Annex A of the Credit Agreement is hereby amended by replacing the number “2.5” with the number “2.25”. 

2.4. Clause (c) of the definition of “Eligible Receivable” in Annex A of the Credit Agreement is hereby
amended and restated in its entirety to read as follows: 
 “(c) the Obligor of which is not (i) an
Affiliate or employee of any Loan Party, or (ii) a Governmental Authority as to which the assignment of receivables owing therefrom requires compliance with the Federal Assignment of Claims Act or other similar legislation (unless the Borrower
has complied therewith);”. 
 2.5. The definition of “Interest Reserve” in Annex A of the Credit Agreement
is hereby amended by (i) replacing the number “2.5” in clause (a)(i) thereof with the number “2.25”, and (ii) replacing the percentage “2.50%” in clause (a)(iii) thereof with the percentage
“2.25%”. 
 2.6. Clause (a) of the definition of “Loss Reserve” in Annex A of the Credit
Agreement is hereby amended by replacing the number “2.5” with the number “2.25”. 
 2.7. The following
definitions in Annex A of the Credit Agreement are hereby amended and restated in their entirety to read as follows: 
 ““Dilution Horizon Ratio” means, on any Settlement Date, an amount calculated by dividing: 
 (a) the product of: (i) the cumulative sales of the Originator generated during the two (2) most recent Settlement Periods, and (ii) the greater of: (x) 1.0, and (y) the result of
(I) the weighted average dilution horizon period as calculated and set forth in the final report most recently delivered to the Agent at least ten (10) days prior to such Settlement Date by the party retained by the Agent to perform the
review contemplated by Section 7.1(c), divided by (II) the number of 

  
 2 

 
days in such two (2) most recent Settlement Periods, by (b) the aggregate Unpaid Balance of all Receivables as of the most recent Cut-Off Date; provided that if a Rating
Event has occurred, the number of Settlement Periods used in each of the calculations set forth in clause (a)(i) shall be increased by one (1) Settlement Period (it being understood and agreed that the weighted average dilution horizon
period as calculated in the report delivered by FTI Consulting, Inc. on or about December 14, 2010, is the weighted average total of 54.8 set forth on page 29 of such report under the heading “Credit Memo Analysis”) .”

 ““Excess Concentration Amount” means, as of any date, the sum of (i) the sum of
the amounts by which the aggregate Unpaid Balance of Receivables of each Obligor exceeds the Obligor Concentration Limit for such Obligor, (ii) the amount by which the Unpaid Balance of all Receivables due and payable between 62 and 91 days of
the original invoice date exceeds the Extended Term Concentration Limit, and (iii) the sum of the amounts by which all Eligible Receivables owing from Obligors that are not domiciled in the United States of America exceeds 5% of the aggregate
Unpaid Balance of all such Eligible Receivables. In computing the Excess Concentration Amount, the Servicer may, at its election, reduce the foregoing sum to reflect the double- or triple-counting of Receivables that constitute excess concentrations
in two or three of the foregoing categories.” 
 ““Fee Letter” means that certain
Fifth Amended and Restated Fee Letter dated as of October 11, 2011 by and among the Servicer, the Borrower, the Agent, and Bank of America, as a Lender, as the same may be amended, restated, supplemented, replaced or otherwise modified from
time to time.” 
 ““Five Year Credit Agreement” means that certain Five Year Credit
Agreement dated as of October 11, 2011, among Packaging Corporation of America, as Borrower, the Initial Lenders named therein, Bank of America, N.A. and Wells Fargo Bank, N.A., as Co-Syndication Agents, JPMorgan Chase Bank, as Administrative
Agent, and the Joint Lead Arrangers and Book Managers party thereto.” 
 ““Scheduled
Termination Date” means October 11, 2014, unless extended by Bank of America, as Lender.” 
 2.8. Exhibit
3.1(a) to the Credit Agreement is hereby amended and restated in its entirety as set forth on Exhibit 3.1(a) hereto. 

SECTION 3. Conditions Precedent. This Amendment shall become effective on the first date on which the Agent shall have received
each of the following, in each case in form and substance satisfactory to it: (i) a counterpart (or counterparts) of (a) this Amendment and (b) that certain amendment fifth amended and restated fee letter agreement, dated as of the
date hereof, among, the Borrower, the Servicer, and the Agent (the “A&R Fee Letter”), in each case executed and delivered by each of the parties hereto or thereto, as applicable, or other evidence satisfactory to the Agent of
the execution and delivery of this Amendment or the A&R Fee Letter 

  
 3 

 
by such parties, (ii) payment in full of the Renewal Fee (as defined in the A&R Fee Letter) pursuant to the terms of the A&R Fee Letter, (iii) a certificate of the Secretary or
Assistant Secretary or other appropriate officer of each Loan Party certifying the names and true signatures of the officers authorized on its behalf to sign this Amendment and the other Transaction Documents to be delivered by it hereunder,
(iv) the Certificate of Formation or other organizational documents of each Loan Party, duly certified by the Secretary of State of such Loan Party’s state of incorporation or organization, as applicable, as of a recent date acceptable to
the Agent in each case together with a copy of the limited liability company agreement or other organizational document of such Loan Party, as applicable, duly certified by the Secretary or an Assistant Secretary of such Loan Party or other
appropriate officer, (v) resolutions of the board of managers or other governing body of each Loan Party authorizing its execution, delivery and performance of this Amendment and the A&R Fee Letter, as applicable, and ratifying the other
Transaction Documents to which it is a party and all other documents evidencing necessary corporate action and government approvals, if any, (vi) copies of good standing certificates or similar certificates of existence for each Loan Party,
issued by the Secretaries of State of the state of incorporation or organization of such Loan Party, as applicable, and the state where such Loan Party’s principal place of business is located if different than the state in which such Loan
Party is incorporated or organized, as applicable, (vii) one or more favorable opinions of counsel to the Loan Parties covering the matters set forth on Schedule I hereto, and (viii) such other agreements, instruments, certificates,
opinions and other documents as the Agent may reasonably request. 
 SECTION 4. Fees and Expenses. The Borrower hereby
covenants and agrees to pay all reasonable fees and expenses in connection with this Amendment, including the reasonable fees of the Agent’s legal counsel, Mayer Brown LLP, within thirty (30) days of presentation of a written invoice
therefor. 
 SECTION 5. Ratification of the PCA Performance Guarantee. The Performance Guarantor hereby acknowledges and
agrees that, immediately after giving effect to this Amendment, the PCA Performance Guarantee shall remain in full force and effect and is hereby ratified and confirmed in all respect. 

SECTION 6. Waiver. Each of the parties hereto hereby waives the notice requirement set forth in Section 1.7 of the
Credit Agreement with respect to the Aggregate Commitment increase evidenced by this Amendment. 
 SECTION 7.
Miscellaneous. 
 7.1. Reaffirmation of Covenants, Representations and Warranties. Upon the effectiveness of this
Amendment, each of the Borrower, the Servicer and the Performance Guarantor hereby reaffirms all covenants, representations and warranties made in the Credit Agreement and each other Transaction Document to which it is a party, as applicable, to the
extent the same are not amended hereby and agrees that all such covenants, representations and warranties shall be deemed to have been remade as of the effective date of this Amendment. 

  
 4 

 7.2. References to Credit Agreement. Upon the effectiveness of this Amendment, each
reference in the Credit Agreement to “this Agreement”, “hereunder”, “hereof”, “herein”, or words of like import shall mean and be a reference to the Credit Agreement as amended hereby, and each reference to
the Credit Agreement in any other document, instrument or agreement executed and/or delivered in connection with the Credit Agreement shall mean and be a reference to the Credit Agreement as amended hereby. 

7.3. Effect on Credit Agreement. Except as specifically amended above, the Credit Agreement and all other documents, instruments
and agreements executed and/or delivered in connection therewith shall remain in full force and effect and are hereby ratified and confirmed. 
 7.4. No Waiver; Transaction Document. Except as set forth in Section 6 above, the execution, delivery and effectiveness of this Amendment shall not operate as a waiver of any right, power or
remedy of the Agent or the Lender under the Credit Agreement or any other document, instrument or agreement executed in connection therewith, nor constitute a waiver of any provision contained therein. The parties hereto hereby agree that this
Amendment is a Transaction Document. 
 7.5. Governing Law. This Amendment, including the rights and duties of the
parties hereto, shall be governed by, and construed in accordance with, the internal laws of the State of New York (without reference to conflicts of laws principles thereof other than Section 5-1401 of the New York General Obligations Law).

 7.6. Successors and Assigns. This Amendment shall be binding upon and shall inure to the benefit of the parties
hereto and their respective successors and assigns. 
 7.7. Headings. The Section headings in this Amendment are inserted
for convenience of reference only and shall not affect the meaning or interpretation of this Amendment or any provision hereof. 

7.8. Counterparts. This Amendment may be executed by the parties hereto in several counterparts, each of which shall be
deemed to be an original and all of which shall constitute together but one and the same agreement. Facsimiles shall be effective as originals. 
 [Signature Pages Follow] 

  
 5 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first written
above. 
  

			
	 BORROWER:
  

PACKAGING RECEIVABLES COMPANY, LLC, a Delaware limited liability company

		
	By:	 	/s/ Darla J. Olivier
		 	 Name: Darla J. Olivier

Title:   Vice President, Tax

  

			
	 SERVICER:
  

PACKAGING CREDIT COMPANY, LLC,
 a Delaware
limited liability company

		
	By:	 	/s/ Darla J. Olivier
		 	 Name: Darla J. Olivier

Title:   Vice President, Tax

  

			
	 PERFORMANCE GUARANTOR:
  

PACKAGING CORPORATION OF AMERICA, a Delaware corporation

		
	By:	 	/s/ Pamela A. Barnes
		 	 Name: Pamela A. Barnes

Title:   Treasurer

 [Signature Pages Continue] 

  
 PCA
Amendment No. 4 to A&R Credit and Security Agreement 

 
			
	 LENDER:
  

BANK OF AMERICA, NATIONAL ASSOCIATION, as Lender

		
	By:	 	/s/ Nina Austin
		 	 Name: Nina Austin
 Title:
  Vice President

  

			
	 AGENT:
  

BANK OF AMERICA, NATIONAL ASSOCIATION

		
	By:	 	/s/ Nina Austin
		 	 Name: Nina Austin
 Title:
  Vice President

  
 PCA
Amendment No. 4 to A&R Credit and Security Agreement 

 EXHIBIT 3.1(a) to Amendment No. 4 

Packaging Receivable Corp. 
 For the Month Ended: 
 X/XX/XXXX 

(Page 1) 
  

					
	 Aggregate Commitment     $200,000,000
	  	 	  	 
			
	 I.       Portfolio Information
	  		  	
			
	 1.      Beginning of Month Balance: (Total A/R Outstanding)
	  		  	______
			
	 2.      Gross Sales (Domestic & Foreign):
	  		  	______
			
	 3.      Deduct:
	  		  	
	 a.      Total Collections:
	  		  	______
	 b.      Dilution
	  		  	______
	 c.      Write Offs
	  		  	______
			
	          Add:
	  		  	
	 d.      Recoveries
	  		  	______
			
	 4.      G/L Ending A/R Balance [(1) + (2) - (3 a,b,c)+(3d)]:
	  		  	______
			
	 5.      Credit Memo Exclusion
	  		  	______
			
	 6.      MSR Ending A/R Balance [(1) + (2) - (3 a,b,c)+(3d)-(5)]:
	  		  	______
			
	 7.      Deduct:
	  		  	
	 a.      Defaulted Receivables
	  	______	  	
	 b.      Government
	  	______	  	
	 c.      Intercompany
	  	______	  	
	 d.      Contra (A/P)
	  	______	  	
	 e.      Accrual for Returns & Allowances
	  	______	  	
	 f.       Unapplied Cash and Credit Balances > 90 DPD
	  	______	  	
	 g.      Bankrupt A/R
	  	______	  	
	 h.      >91 Day Selling Terms
	  	______	  	
	 i.       Notes Receivables
	  	______	  	
	 j.       Third Party Collection Agency & Cash on Demand
	  	______	  	
	 k.      Cross Age @ 35%
	  	______	  	
	 l.       Other Ineligibles (Alcoa and Stanley)
	  	______	  	
	 m.     Short Pays/Customer Deductions
	  	______	  	
	 n.      End of Month Volume rebate accrual
	  	______	  	
	 o.      Total Ineligibles
	  		  	______
	 8.      Eligible Receivables [(6) - (7 p-n)]:
	  		  	______
			
	 9.      Deduct:
	  		  	
	 a.      Excess Concentration:
	  		  	______
	          Obligor
	  		  	______
	          Foreign
	  		  	______
	 b.      Excess 62-91 Day Selling Terms
	  		  	______
	 c.      Recoveries
	  		  	______
			
	 10.    Net Pool Balance [(8) - (9 a,b,c)]:
	  		  	______

													
							
	11.    	  	 Aging

Schedule:
	  	Current
Month	  	%	  	One Month
Prior	  	Two Months
Prior	  	Three Months
Prior
	 a.
	  	Current	  		  		  		  		  	
	 b.
	  	1-30 Days Past Due	  		  		  		  		  	
	 c.
	  	31-60 Days Past Due	  		  		  		  		  	
	 d.
	  	61-90 Days Past Due	  		  		  		  		  	
	 e.
	  	91-120 Days Past Due	  		  		  		  		  	
	 f.
	  	121-150 Days Past Due	  		  		  		  		  	
	 g.
	  	151-180 Days Past Due	  		  		  		  		  	
	 h.
	  	180 + Days Past Due	  		  		  		  		  	
	 j.
	  	Total:	  		  		  		  		  	

 Packaging Receivable Corp. 

For the Month Ended: 
 X/XX/XXXX 
 (Page 2) 

 

													
	 II.     Calculations Reflecting Current Activity
	  				 				  			
	 12.    Loan Amount Outstanding
	  				 				  	 	______	  
	 13.    Required Reserve % (sum of a, b, c)
	  				 				  	 	______	  
	 a.      Maximum of:
	  				 				  	 	______	  
	 (i)     Minimum Reserve Ratio %
	  				 				  	 	______	  
	 (ii)    Dynamic Reserve Ratio %
	  				 				  	 	______	  
	 (1)    Dynamic Dilution Reserve %
	  				 				  	 	______	  
	 (2)    Dynamic Loss Reserve %
	  				 				  	 	______	  
	 b.      Servicing Reserve
	  				 				  	 	______	  
	 c.      Interest Reserve
	  				 				  	 	______	  
	 14.    Required Reserve
	  				 				  	 	______	  
	 15.    Excess Deemed Collections
	  				 				  	 	______	  
	 16.    Borrowing Base
	  				 				  	 	______	  
	 17.    Funding Availability based on Aggregate Commitment
	  				 				  	$	200,000,000	  
	 18.    Additional Availability or (Required Paydown)
	  				 				  	 	______	  
				
	 III.    Compliance
	  				 				  			
	 19.    Asset Interest [(10) + (17) / (8)] < 100%:
	  				 	 	In Compliance	  	  	 	______	 
	 20.    3M Avg. Delinquency Ratio
	  	 	2.00	% 	 	 	In Compliance	  	  	 	______	 
	 a.      1M Delinquency Ratio (Current Month)
	  				 				  	 	______	 
	 b.      1M Delinquency Ratio (1-month Prior)
	  				 				  	 	______	 
	 c.      1M Delinquency Ratio (2-months Prior)
	  				 				  	 	______	 
	 21.    3M Avg. Default Ratio
	  	 	1.25	% 	 	 	In Compliance	  	  	 	______	 
	 a.      1M Default Ratio (Current Month)
	  				 				  	 	______	 
	 b.      1M Default Ratio (1-month Prior)
	  				 				  	 	______	 
	 c.      1M Default Ratio (2-months Prior)
	  				 				  	 	______	 
	 22.    3M Avg. Dilution Ratio
	  	 	1.75	% 	 	 	In Compliance	  	  	 	______	 
	 a.      1M Dilution Ratio (Current Month)
	  				 				  	 	______	 
	 b.      1M Dilution Ratio (1-month Prior)
	  				 				  	 	______	 
	 c.      1M Dilution Ratio (2-months Prior)
	  				 				  	 	______	 
	 23.    Maximum Debt to EBITDA Ratio
	  	 	3.5	  	 	 	In Compliance	  	  	 	______	 
	 24.    Minimum EBITDA to Interest Ratio
	  	 	3.5	  	 	 	In Compliance	  	  	 	______	 

 Packaging Receivable Corp. 

For the Month Ended: 
 X/XX/XXXX 
 (Page 3) 

 

	IV.	Excess Concentrations: (Calculation) 

 Eligible Receivables 

							
	Allowable Percentage	 	 	Max. Allowable Balance	  	 Credit Rating

	 	2.0	% 	 		  	NR/NR
	 	3.0	% 	 		  	A3/P3
	 	6.0	% 	 		  	A2/P2
	 	8.0	% 	 		  	A1/P1
	 	10.0	% 	 		  	A1+/P1

  

															
	 	 	  	 Largest

Obligors
	  	Short-Term
Debt Rating	  	Allowable
Percentage	  	Total
Receivables	  	Allowable
Receivables	  	Excess
Receivables
	 	1	  	  		  		  		  		  		  	
	 	2	  	  		  		  		  		  		  	
	 	3	  	  		  		  		  		  		  	
	 	4	  	  		  		  		  		  		  	
	 	5	  	  		  		  		  		  		  	
	 	6	  	  		  		  		  		  		  	
	 	7	  	  		  		  		  		  		  	
	 	8	  	  		  		  		  		  		  	
	 	9	  	  		  		  		  		  		  	
	 	10	  	  		  		  		  		  		  	
	 	11	  	  		  		  		  		  		  	
	 	12	  	  		  		  		  		  		  	
	 	13	  	  		  		  		  		  		  	
	 	14	  	  		  		  		  		  		  	
	 	15	  	  		  		  		  		  		  	
	 	16	  	  		  		  		  		  		  	
	 	17	  	  		  		  		  		  		  	
	 	18	  	  		  		  		  		  		  	
	 	19	  	  		  		  		  		  		  	
	 	20	  	  		  		  		  		  		  	
	 	21	  	  		  		  		  		  		  	
	 	22	  	  		  		  		  		  		  	
	 	23	  	  		  		  		  		  		  	
	 	24	  	  		  		  		  		  		  	
	 	25	  	  		  		  		  		  		  	
				  	 Total Obligor Concentrations
	  		  		  		  		  	

  

											
	 	  	Allowable
Percentage	 	 	Total
Receivables	  	Allowable
Receivables	  	Excess
Receivables
	 Foreign Receivables
	  	 	5.00	% 	 		  		  	
	 Total Excess Concentrations
	  				 		  		  	

 The undersigned hereby represents and warrants that the foregoing is a true and accurate accounting with respect to
outstanding receivables as of __________ XX, XXXX. In accordance with the Receivables Purchase Agreement dated November 29, 2000 and that all representations and warranties related to such Agreement are restated and reaffirmed. 

 

									
	Signed:	 	 	 		 	Date	 	                             
                            XX, XXXX           
     
					
	 Title:
	 		 		 		 	

  
 PCA
Amendment No. 4 to A&R Credit and Security Agreement 

 SCHEDULE I to Amendment No. 4 

SUBSTANCE OF CORPORATE OPINION(S) 
  

	•	 	 All opinions should be addressed to the Agent and the Lenders and should permit reliance thereon by (A) the Liquidity Banks and (B) S&P
and Moody’s. 

  

	•	 	 The opinion giver for the opinion identified in item 3 below must be licensed to practice in the state whose law governs the Credit Agreement and the
Performance Guarantee, as applicable (i.e., New York). 

  

	•	 	 Corporate opinions should address the following matters as to the Loan Parties: 

1. Each of the Loan Parties has been duly organized and is validly existing under the laws of Delaware, with power and authority to
conduct its business as now conducted, to own, or hold under lease, its assets and to enter into the Amendment and the A&R Fee Letter to which it is a party and perform its obligations under the Amendment, the A&R Fee Letter and the Credit
Agreement, as amended through and including the date hereof, including by the Amendment (collectively, the “Amendment Documents”). Based solely on certificates from public officials, we confirm that (i) each of the Loan Parties
(other than the Borrower) is qualified to do business in the following States: Delaware and Illinois, and (ii) the Borrower is qualified to do business in Delaware. 
 2. The execution, delivery and performance of the Amendment Documents to which any of the Loan Parties is a party have been duly authorized by all necessary action of such Loan Party, and such Amendment
Documents have been duly executed and delivered by such Loan Party. 
 3. Each of the Transaction Documents constitutes a
legally valid and binding obligation of each of the Loan Parties signatory thereto, enforceable against such Loan Party in accordance with its terms. 
 4. The execution and delivery of the Amendment Documents by each of the Loan Parties signatory thereto, and the performance of their respective obligations do not: (a) violate any federal or the
State of Delaware (or, with respect to Servicer and the Performance Guarantor, the State of Illinois) statute, rule or regulation applicable to the Loan Parties (including, without limitation, Regulations T, U or X of the Board of Governors of the
Federal Reserve System), (b) violate the provisions of the Loan Parties’ respective Governing Documents, (c) result in the breach of or a default under, the creation of a lien under or the acceleration of indebtedness pursuant to any
indenture, credit agreement, lease, note or other agreement, instrument or contract or any judgment, writ or other court order, in any of the foregoing cases, which has been identified to you as being material to any of the Loan Parties, or
(d) require any consents, approvals, authorizations, registrations, declarations or filings by any of the Loan Parties under any federal or the State of Delaware (or, with respect to Servicer and the Performance Guarantor, the State of
Illinois) statute, rule or regulation applicable to any of the Loan Parties of the State of Delaware (or, with respect to Servicer and the Performance Guarantor, the State of Illinois) except the filing of financing statements which have already
been filed. 
  

  
 PCA
Amendment No. 4 to A&R Credit and Security Agreement 

 5. The Borrower is not an “investment company” within the meaning of the
Investment Company Act of 1940, as amended. 
 PCA Amendment No. 4 to A&R Credit and Security AgreementForm of Registration Rights Agreement

 Exhibit 4.2 
 CEMPRA, INC. 
  

 
 REGISTRATION
RIGHTS AGREEMENT 
  
  

[          ], 2011 

 CEMPRA, INC. 

 
  

REGISTRATION RIGHTS AGREEMENT 
  

 
 TABLE OF
CONTENTS 
  

							
	 	 	 	  	Page	 
	 SECTION 1. RESTRICTIONS ON TRANSFER
	  	 	1	  
	 1.1
	 	 Restrictive Legend
	  	 	1	  
		
	 SECTION 2. REGISTRATION RIGHTS
	  	 	2	  
	 2.1
	 	 Certain Definitions
	  	 	2	  
	 2.2
	 	 Demand Registration
	  	 	3	  
	 2.3
	 	 Piggyback Registration
	  	 	5	  
	 2.4
	 	 Expenses of Registration
	  	 	6	  
	 2.5
	 	 Obligations of the Company
	  	 	7	  
	 2.6
	 	 Indemnification
	  	 	10	  
	 2.7
	 	 Information by Holder
	  	 	12	  
	 2.8
	 	 Transfer and Assignment of Rights
	  	 	12	  
	 2.9
	 	 Form S-3
	  	 	13	  
	 2.10
	 	 Delay of Registration
	  	 	13	  
	 2.11
	 	 Limitations on Subsequent Registration Rights
	  	 	13	  
	 2.12
	 	 Rule 144 Reporting
	  	 	14	  
	 2.13
	 	 Market Stand Off Agreement
	  	 	14	  
	 2.14
	 	 Termination of Rights
	  	 	15	  
		
	 SECTION 3. MISCELLANEOUS
	  	 	15	  
	 3.1
	 	 Governing Law
	  	 	15	  
	 3.2
	 	 Successors and Assigns
	  	 	15	  
	 3.3
	 	 Entire Agreement
	  	 	15	  
	 3.4
	 	 Severability
	  	 	15	  
	 3.5
	 	 Amendment and Waiver
	  	 	16	  
	 3.6
	 	 Delays or Omissions
	  	 	16	  
	 3.7
	 	 Notices, etc
	  	 	16	  
	 3.8
	 	 Titles and Subtitles
	  	 	17	  
	 3.9
	 	 Counterparts
	  	 	17	  
	 3.10
	 	 Further Assurances
	  	 	17	  

 CEMPRA, INC. 

 
  

REGISTRATION RIGHTS AGREEMENT 
  

 
 This
Registration Rights Agreement (the “Agreement”) is dated this          day of           , 201  , by and among Cempra, Inc., a
Delaware corporation (the “Company”) and the persons set forth on Exhibit A attached hereto (the “Holders”). This Agreement shall become effective upon the effectiveness of the Conversion (as defined below).

 RECITALS 
 WHEREAS, prior to its initial public offering (the “Offering”), the Company operated as Cempra Holdings, LLC, a Delaware limited liability company; 

WHEREAS, to facilitate the Offering, Cempra Holdings, LLC converted (the “Conversion”) to a Delaware corporation
pursuant to a Plan of Conversion dated           , 2011 (the “Plan of Conversion”); 
 WHEREAS, each of the Holders previously held registration rights as set forth in the Second Amended and Restated Limited Liability Company Agreement dated May 13, 2009, as amended (the “LLC
Agreement”); 
 WHEREAS, as a result of the Conversion, the LLC Agreement was terminated; and 

WHEREAS, pursuant to the Plan of Conversion, the Company will provide the Holders with certain rights with respect to the registration of
the shares of Common Stock of the Company (the “Common Stock”) they hold or have rights to as of the effective time of this Agreement. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the mutual agreements,
covenants and conditions contained herein, the Company and the Holders hereby agree as follows. 
 SECTION 1. 

RESTRICTIONS ON TRANSFER 
 1.1 Restrictive Legend. Each certificate representing the Registrable Securities (as defined below) (unless otherwise permitted by the provisions of Section 1.2 below) be stamped or otherwise
imprinted with a legend in substantially the following form (in addition to any legend required under applicable state securities laws). 

 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE SOLD, MORTGAGED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED WITHOUT AN
EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND ANY APPLICABLE STATE SECURITIES LAWS, OR THE AVAILABILITY OF AN EXEMPTION FROM THE REGISTRATION PROVISIONS OF THE SECURITIES ACT OF 1933, AS
AMENDED, AND APPLICABLE STATE SECURITIES LAWS. COPIES OF THE REGISTRATION RIGHTS AGREEMENT PROVIDING FOR RESTRICTIONS ON TRANSFER OF THESE SECURITIES MAY BE OBTAINED UPON WRITTEN REQUEST BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY
OF THE CORPORATION AT THE PRINCIPAL EXECUTIVE OFFICES OF THE CORPORATION. 
 Such restrictive legend shall be removed in
connection with (i) any transfer to the public in accordance with the provisions of Rule 144 (or any other rule permitting public sale without registration under the Securities Act of 1933, as amended, and the rules and regulations promulgated
thereunder (the “1933 Act”)); (ii) any transfer pursuant to an effective registration statement under the 1933 Act; or (iii) any transfer in connection with which the transferring holder delivers to the Company any opinion
of counsel reasonably acceptable to the Company to the effect that the transferee would be entitled to transfer such securities in a public sale without registration under the 1933 Act. Notwithstanding the foregoing clause (iii), no such opinion of
counsel shall be necessary for a transfer by a Holder which is (a) a partnership to its partners or former partners in accordance with the partnership interests, (b) a limited liability company to its members or former members in
accordance with their interest in the limited liability company, or (c) a corporation to its stockholders in accordance with their interest in the corporation, provided, that in each case the transferee will be subject to the terms of this
Agreement to the same extent as if he or she were an original Holder hereunder. 
 SECTION 2. 

REGISTRATION RIGHTS 
 The Company hereby grants to each of the Holders the registration rights set forth in this Section 2 with respect to the Registrable Securities owned by such Holders. The Company and the Holders
agree that the registration rights provided herein set forth the sole and entire agreement, and supersede any prior agreement, between the Company and the Holders with respect to registration rights for the Company’s securities. 

2.1 Certain Definitions. As used in this Section 2, the following terms shall have the following meanings. 

  
 2 

 (a) The terms “register”, “registered” and
“registration” refer to a registration effected by filing with the Securities and Exchange Commission (the “SEC”) a registration statement (the “Registration Statement”) in compliance with the 1933
Act, and the declaration or ordering by the SEC of the effectiveness of such Registration Statement. 
 (b) The
term “Registrable Securities” means: (a) any shares of Common Stock issued to the Holders upon the conversion of their preferred shares of Cempra Holdings, LLC at the effective time of this Agreement pursuant to the Plan of
Conversion; (b) any shares of Common Stock issuable to the Holders upon the conversion of their unsecured convertible promissory notes as of the effective time of this Agreement and as amended from time to time, issued to them pursuant to that
certain Unsecured Convertible Promissory Note and Warrant Purchase Agreement dated August 5, 2011, by and among Cempra Holdings, LLC and various persons listed therein (the “Purchase Agreement”), (c) any shares of Common
Stock to which the Holders have rights as of the effective time of this Agreement pursuant to the preferred share purchase warrants issued and as amended from time to time under the Purchase Agreement or any replacement warrants to purchase Common
Stock issued to Holders upon an initial public offering; and (d) any shares of Common Stock issued or issuable with respect to any shares described in subsection (a) above by way of a stock dividend or stock split or in connection with a
combination of shares, recapitalization, merger, consolidation or other reorganization (it being understood that for purposes of this Agreement, a Person shall be deemed to be a holder of Registrable Securities whenever such Person has the right to
then acquire or obtain from the Company any Registrable Securities, whether or not such acquisition has actually been effected). Shares of Common Stock shall only be treated as Registrable Securities if and so long as (A) they have not been
sold to or through a broker or dealer or underwriter in a public distribution or a public securities transaction and (B) they have not been sold in a transaction exempt from the registration and prospectus delivery requirements of the 1933 Act
under Section 4(1) thereof so that all transfer restrictions and restrictive legends with respect thereto are removed upon the consummation of such sale. 
 (c) The term “Initiating Holders” means any Holder or Holders of at least 25% of the Registrable Securities then outstanding and not registered at the time of any request for registration
made pursuant to Section 2.2 of this Agreement. 
 (e) The term “Person” means an
individual, corporation, partnership, joint venture, limited liability company, Governmental Authority, unincorporated organization, trust, association or other entity. 
 2.2 Demand Registration. 
 (a) Demand for
Registration. Beginning six (6) months after the effective date of the initial public offering of the Company’s securities, if the Company shall receive from Initiating Holders a written demand that the Company effect any registration
(a “Demand Registration”) of Registrable Securities (other than a registration on Form S-3 or any related form of registration statement, such a request being provided for under Section 2.9 hereof) with an anticipated aggregate
offering price of at least $1,500,000, the Company will: 

  
 3 

 (i) promptly (but in any event within ten (10) days) give written
notice of the proposed registration to all other Holders; and 
 (ii) use its best efforts to effect such
registration as soon as practicable and as will permit or facilitate the sale and distribution of all or such portion of such Initiating Holders’ Registrable Securities as are specified in such demand, together with all or such portion of the
Registrable Securities of any Holder or Holders joining in such demand as are specified in a written demand received by the Company within fifteen (15) days after such written notice is given, provided that the Company shall not be obligated to
take any action to effect any such registration pursuant to this Section 2.2: 
 (A) after the Company has
effected two (2) such registrations pursuant to this Section 2.2; or 
 (B) if the Company shall
furnish to such Holders a certificate signed by the President of the Company, stating that in the good faith judgment of the Board of Directors of the Company it would be seriously detrimental to the Company and its equity holders for such
Registration Statement to be filed at the date filing would be required, in which case the Company shall have an additional period or periods of not more than ninety (90) days within which to file such Registration Statement; provided, however,
that the Company shall not use this right to delay the filing more than once nor for any period greater than ninety (90) days in the aggregate in any 12 consecutive month period; 

(b) Underwriting. If the Initiating Holders intend to distribute the Registrable Securities covered by their demand
by means of an underwriting, they shall so advise the Company as part of their demand made pursuant to this Section 2.2 and the Company shall include such information in the written notice referred to in Section 2.2(a)(i). The managing
underwriter shall be mutually agreed upon by the Initiating Holders and the Board of Directors. In such event, the right of any Holder to registration pursuant to this Section 2.2 shall be conditioned upon such Holder’s participation in
such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. 
 The Company shall, together with the Holders of Registrable Securities proposing to distribute their securities through such underwriting, enter into an underwriting agreement in customary form with the
underwriter or underwriters mutually agreed upon by the Company and a majority-in-interest of the Initiating Holders. Notwithstanding any other provision of this Section 2.2, if the underwriter shall advise the Company that marketing factors
(including, without limitation, an adverse effect on the per share offering price) require a limitation of the number of shares to be underwritten, then the Company shall so advise all Holders of Registrable Securities that have requested to
participate in such offering, and the number of shares of Registrable Securities that may be included in the registration and underwriting shall be allocated pro rata among such Holders thereof in proportion, as nearly as practicable, to the amounts
of Registrable Securities held by such Holders at the time of filing the Registration Statement. No 

  
 4 

 
Registrable Securities excluded from the underwriting by reason of the underwriter’s marketing limitation shall be included in such registration. 

If any Holder disapproves of the terms of the underwriting, such Holder may elect to withdraw therefrom by written notice to the Company,
the underwriter and the Initiating Holders. The Registrable Securities so withdrawn shall also be withdrawn from registration. 

No securities other than Registrable Securities shall be included among the securities covered by such registration without the prior
written consent of Holders of at least sixty-six and two-thirds percent (66 2/3%) of the Registrable Securities requested to be included in the offering. 
 If the underwriter has not limited the number of Registrable Securities to be underwritten, the Company may include securities for its own account (or for the account of other equity holders) in such
registration if the underwriter so agrees and if the number of Registrable Securities would not thereby be limited. A Demand Registration under this Section 2.2 shall not be deemed to have occurred nor be considered a Demand Registration for
purposes of the limit on Demand Registrations which may be requested pursuant to 2.2(a) above, if the number of Registrable Securities included in a registration is reduced in accordance with this Section 2.2(b) such that less than fifty
percent (50%) of the Registrable Securities sought to be included in such registration are included. 
 2.3 Piggyback
Registration. 
 (a) Company Registration. If at any time or from time to time the Company shall
determine to register any of its securities, either for its own account or for the account of security holders, other than a registration relating solely to employee benefit plans, an initial public offering, a registration on Form S-4 relating
solely to an SEC Rule 145 transaction or a registration pursuant to Section 2.2 or 2.9 hereof, the Company will: 
 (i) promptly (but in any event within 10 days) give to each Holder written notice thereof; and 
 (ii) include in such registration (and any related qualification under state securities laws or other compliance), and in any underwriting involved therein, all the Registrable Securities specified in a
written request or requests, made within 30 days after receipt of such written notice from the Company, by any Holder or Holders, except as set forth in Section 2.3(b) below. 

(b) Underwriting. If the registration of which the Company gives notice is for a registered public offering
involving an underwriting, other than an initial public offering, the Company shall so advise the Holders as a part of the written notice given pursuant to Section 2.3(a)(i). In such event the right of any Holder to registration pursuant to
this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. 

  
 5 

 All Holders proposing to distribute their Registrable Securities through such underwriting
shall, together with the Company and the other parties distributing their securities through such underwriting, enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the
Company. Notwithstanding any other provision of this Section 2.3, if the underwriter determines in writing that the inclusion of all Registrable Securities which the Holders have requested be included would materially jeopardize the success of
the offering, the Company may limit the number of Registrable Securities to be included in the registration and underwriting, or may exclude Registrable Securities entirely from such registration and underwriting subject to the terms of this
Section 2.3. The Company shall so advise all holders of the Company’s securities that would otherwise be registered and underwritten pursuant hereto, and the number of shares of such securities, including Registrable Securities, that may
be included in the registration and underwriting shall be allocated in the following manner: (i) first, shares, other than Registrable Securities and other securities that have contractual rights with respect to registration similar to those
provided for in this Section 2.3, requested to be included in such registration by stockholders shall be excluded, and (ii) second, if a limitation on the number of shares still is required, securities other than Registrable Securities
that have contractual rights with respect to registration shall be excluded, and (iii) third, if a limitation on the number of shares is still required, the number of Registrable Securities that may be included shall be allocated among the
Holders thereof in proportion, as nearly as practicable, to the amounts of Registrable Securities held by each such Holder at the time of filing the Registration Statement. No securities excluded from the underwriting by reason of the
underwriter’s marketing limitation shall be included in such registration. Except as specifically set forth herein, nothing in this Section 2.3(b) is intended to diminish the number of securities to be included by the Company in the
underwriting. 
 If any Holder disapproves of the terms of the underwriting, it may elect to withdraw therefrom by written
notice to the Company and the underwriter. The Registrable Securities so withdrawn shall also be withdrawn from registration and the Company shall bear all of the expenses incurred in connection with such registration as provided in Section 2.4
below. 
 (c) Right to Terminate Registration. The Company shall have the right to terminate or withdraw
any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. Notwithstanding any such withdrawal, the Company shall pay
all expenses incurred by the Holders of Registrable Securities in connection with such Piggyback Registration as provided in Section 2.4. Registrations effected pursuant to this Section 2.3 shall not be counted as Demand Registrations
effected pursuant to Section 2.2. 
 2.4 Expenses of Registration. All expenses incurred by the Company in
performing or complying with its obligations under this Agreement in connection with the registration of Registrable Securities under Sections 2.2, 2.3 or 2.9, including, without limitation, all registration and filing fees, including fees with
respect to filings required to be made with the Securities Exchange Commission (the “SEC”), the National Association of Securities Dealers, Inc., fees and expenses of compliance with securities or “blue sky” laws
(including, without limitation, reasonable fees and disbursements of counsel for the underwriters and counsel in connection with blue sky qualifications of the Registrable 

  
 6 

 
Securities), printing expenses, messenger, telephone and delivery expenses, fees and disbursements of counsel of the Company and of all independent public accountants of the Company (including
the expenses of any special audit and “comfort” letters required by or incident to such performance), reasonable fees and disbursements of one counsel for the selling Holders (such fees and expenses not to exceed $30,000), underwriters
fees (excluding underwriter discounts or selling commissions attributable to the Registrable Securities being sold by the Holders thereof, which shall be paid by the selling Holders on a pro rata basis based on the number of Registrable Securities
being sold by them), securities acts liability insurance (to the extent then available on reasonable commercial terms), and fees and expenses of other persons or entities retained by the Company (including, without limitation, all salaries and
expenses of its officers and employees) will be borne by the Company whether or not any of the Registration Statements become effective. Notwithstanding anything to the contrary above, the Company shall not be required to pay for any expenses of any
registration proceeding under Section 2.2 if the registration request is subsequently withdrawn at the request of the Initiating Holder of the Registrable Securities to have been registered, in which event either such registration shall count
as a demand registration pursuant to Section 2.2 and the Company shall bear all of the expenses incurred in connection with such registration, or at the election of the Holders of a majority of the Registrable Securities to have been
registered, such registration shall not count as a demand registration and the Holders of Registrable Securities to have been registered shall bear all such expenses pro rata on the basis of the Registrable Securities to have been registered.
Notwithstanding the preceding sentence, however, if at the time of the withdrawal, the Holders have learned of a materially adverse change in the condition, business or prospects of the Company from that known to the Holders at the time of their
request, then the Holders shall not be required to pay any of said expenses and shall retain their rights pursuant to Section 2.2 and provided, further, that the Company shall not be required to pay for any expenses of any registration pursuant
to Section 2.9 if the Company has effected two (2) registrations pursuant to Section 2.9 in the preceding twelve (12) months and paid the expenses thereof, in which event the Holders of Registrable Securities to be registered
shall bear all such expenses pro rata on the basis of Registrable Securities to be registered. 
 2.5 Obligations of the
Company. Whenever required under Sections 2.2, 2.3 or 2.9 to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible (or within ninety (90) days with respect to clause (a)):

 (a) prepare and file with the SEC a Registration Statement with respect to such Registrable Securities and use
its reasonable best efforts to cause such Registration Statement to become effective, and keep such Registration Statement effective for the lesser of one hundred and twenty (120) days or until the Holder or Holders have completed the
distribution relating thereto; provided, however, that (i) such 120-day period shall be extended for a period of time equal to the period the Holder refrains from selling any securities included in such registration at the request of an
underwriter of Common Stock (or other securities) of the Company and (ii) in the case of any registration of Registrable Securities on Form S-3 which are intended to be offered on a continuous or delayed basis, subject to compliance with
applicable SEC rules, such 120-day period shall be extended, if necessary, to keep the Registration Statement effective until all such Registrable Securities are sold; 

  
 7 

 (b) prepare and file with the SEC such amendments and supplements to such
Registration Statement and the prospectus used in connection with such Registration Statement as may be necessary to keep such Registration Statement effective and to comply with the provisions of the 1933 Act with respect to the disposition of all
securities covered by such Registration Statement for the period set forth in paragraph (a) above; 
 (c)
furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of the 1933 Act, and such other documents as they may reasonably request in order to facilitate the disposition of
Registrable Securities owned by them; 
 (d) concurrently with the effectiveness of the Registration Statement
qualify the securities covered by such Registration Statement under such other securities or Blue Sky laws of such states and other jurisdictions as shall be reasonably requested by the Holders or the managing underwriter, provided, that the Company
shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions unless the Company is already subject to service in such
jurisdiction and except as may be required by the 1933 Act; 
 (e) in the event of any underwritten public
offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering. Each Holder participating in such underwriting shall also enter into and perform its
obligations under such an agreement subject to the limitations in Sections 2.2 and 2.3; 
 (f) notify each Holder
of Registrable Securities covered by such Registration Statement, at any time when a prospectus relating thereto is required to be delivered under the 1933 Act, of the happening of any event as a result of which the prospectus included in such
Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances
then existing, and prepare and furnish to each Holder a reasonable number of copies of a supplement to or amendment of such prospectus so that, as thereafter delivered to the purchasers of such Registrable Securities, such prospectus will not
contain an untrue statement of a material fact or omit to state a material fact necessary to make the statements therein not misleading in light of the circumstances under which they were made; 

(g) use its best efforts to list the Registrable Securities covered by such Registration Statement on a national
securities exchange or trading system and on any securities exchange on which the Common Stock is then listed; 

(h) cause all such Registrable Securities to be listed on each securities exchange or reported on each consolidated
reporting system on which similar securities issued by the Company are then listed or reported, as the case may be; 

  
 8 

 (i) provide a transfer agent and registrar for all such Registrable
Securities not later than the effective date of such Registration Statement; 
 (j) furnish, at the request of
any Holder or Holders requesting registration of Registrable Securities pursuant to Sections 2.2, 2.3 or 2.9 hereof, on the date that such Registrable Securities are delivered to the underwriters for the sale pursuant to such registration or, if
such Registrable Securities are not being sold through underwriters, on the date that the registration statement (or any amendment or supplement thereto) with respect to such Registrable Securities becomes effective, (x) an opinion, dated such
date, of the counsel representing the Company for the purposes of such registration, addressed to the underwriters, if any, and to the Holder or Holders making such request, covering such legal matters with respect to the registration in respect of
which such opinion is being given as the Holder requesting such opinion may reasonably request, in customary form and covering such matters of the kind customarily covered by such legal opinions, and (y) a comfort letter or comfort letters
dated such date, from the independent certified public accountants of the Company, addressed to the underwriters, if any, and to the Holder or Holders making such request, stating that they are independent certified public accountants within the
meaning of the 1933 Act, in customary form and covering such matters of the kind customarily covered by such comfort letter(s). Such comfort letter(s) from the independent certified public accountants shall additionally cover such other financial
matters with respect to the registration in respect of which such letter is being given as the Holder requesting such letter may reasonably request; provided such matters are of a nature that accountants are normally required to opine upon in
connection with such registration and which shall be necessary to effectuate such registration or offering. 

(k) use its reasonable efforts to comply with all applicable rules and regulations of the SEC, and make available to its
security holders, as soon as reasonably practicable, an earnings statement or such other document covering a period of twelve (12) months, beginning within three months after the effective date of the registration statement, which earnings
statement shall satisfy the provisions of Section 11(a) of the 1933 Act and Rule 158 (or any successor provision) thereunder. 
 (l) allow a representative designated by a majority in interest of the Holders participating in the registration (the “Holder Representative”) to participate in the preparation of the
Registration Statement, each prospectus included therein or filed with the SEC and each amendment or supplement thereto and make available for inspection by each Holder including Registrable Securities in such registration, any underwriter
participating in any distribution pursuant to such registration, and any attorney, accountant, advisors or other agent retained by such Holder or underwriter, all financial and other records, pertinent corporate documents and properties of the
Company, as such parties may reasonably request, and cause the Company’s officers, directors and employees and independent accountants to supply all information reasonably requested by any such Holder, underwriter, attorney, accountant, advisor
or agent in connection with such Registration Statement; 
 (m) cooperate with Holders including Registrable
Securities in such registration and the managing underwriters, if any, to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold, such certificates to be in

  
 9 

 
such denominations and registered in such names as such Holders or the managing underwriters may request at least two (2) business days prior to any sale of Registrable Securities; and

 (n) permit the Holder Representative to participate in good faith in the preparation of such Registration
Statement and to require the insertion therein of material, furnished to the Company in writing, that in the reasonable judgment of such Holder and its counsel should be included. 

2.6 Indemnification. 
 (a) The Company will indemnify and hold harmless each Holder participating in the registration, its directors, stockholders, officers, partners, advisers, employees, affiliates, members, attorneys and
agents and each underwriter involved in such registration and each other person, if any, who controls each selling Holder or underwriter within the meaning of the 1933 Act or the Securities Exchange Act of 1934, as amended (the “1934
Act”) from and against any losses, judgments, claims, damages or liabilities, whether joint or several, to which each selling Holder or its officers, directors, stockholders, advisers, employees, affiliates, members, attorneys, agents or
partners or underwriter or controlling person may become subject arising out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in any Registration Statement under which such Registrable Securities
were registered under the 1933 Act, any preliminary prospectus, final prospectus or summary prospectus contained in such Registration Statement, or any amendment or supplement to such Registration Statement, or arising out of or are based upon the
untrue statement of a material fact or omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading, or any violation by the Company of the 1933 Act applicable to the
Company and relating to any action or inaction required of the Company in connection with any such registration, and will reimburse such selling Holder, its officers, directors, stockholders, advisers, employees, affiliates, members, attorneys,
agents and partners and such underwriter and each such controlling person for any legal or any other expenses reasonably incurred by any of them as they are incurred in connection with investigating or defending any such loss, judgment, claim,
damage, liability or action; provided, however, that the Company will not be liable to a selling Holder or its officers, directors, stockholders, advisers, employees, affiliates, members, attorneys, agents or partners, or controlling persons in any
such case to the extent that any such loss, judgment, claim, damage or liability arises out of or is based upon any untrue statement or omission made in such Registration Statement, preliminary prospectus, final prospectus or summary prospectus, or
any such amendment or supplement thereto, in reliance upon and in conformity with information furnished to the Company, in writing, by such selling Holder specifically for use therein. 

(b) If Registrable Securities held by or issuable to a Holder are included in such registration, qualification or
compliance pursuant to this Section 2, such Holder does hereby undertake to indemnify and hold harmless the Company, each of its directors and officers, and each person controlling the Company, each underwriter, if any, and each person who
controls any underwriter, of the Registrable Securities covered by such a Registration Statement, and each other Holder, each of such other Holder’s officers, directors, managers, partners, members and agents and each person controlling such
other Holder, against all claims, losses, damages 

  
 10 

 
and liabilities (or actions in respect thereof) arising out of or based on any untrue statement (or alleged untrue statement) of a material fact contained in any such Registration Statement,
prospectus, offering circular or other document, or any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances in which
they were made, and will reimburse, as incurred, the Company, each such underwriter, each such other Holder and each such director, officer, manager, partner, member, agent and controlling person of the foregoing, for any legal or any other expenses
reasonably incurred in connection with investigating or defending any such claim, loss, damage, liability or action, in each case to the extent, but only to the extent, that such untrue statement (or alleged untrue statement) or omission (or alleged
omission) was made in such Registration Statement, prospectus, offering circular or other document, in reliance upon and in conformity with written information furnished to the Company by an instrument duly executed by such Holder and stated to be
specifically for use therein; provided, however, that the liability of each Holder hereunder shall be limited to the net proceeds received by such Holder from the sale of securities under such Registration Statement. It is understood and agreed that
the indemnification obligations of each Holder pursuant to any underwriting agreement entered into in connection with any Registration Statement shall be limited to the obligations contained in this Subsection 2.6(b). 

(c) Each party entitled to indemnification under this Section 2.6 (the “Indemnified Party”) shall
give notice to the party required to provide such indemnification (the “Indemnifying Party”) of any claim as to which indemnification may be sought promptly after such Indemnified Party has actual knowledge thereof, and shall permit
the Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom; provided that counsel for the Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be subject to approval by the
Indemnified Party (whose approval shall not be unreasonably withheld) and the Indemnified Party may participate in such defense at the Indemnified Party’s expense. If representation of such Indemnified Party would be inappropriate due to actual
or potential differing interests between such Indemnified Party and any other party represented by such counsel in such proceeding or if the Indemnifying Party shall fail, within a reasonable time after notice of the claim, to have given written
notice of its intention to assume such defense, and to have employed counsel approved by the Indemnified Party to assume the defense of such claim or litigation, or the Indemnifying Party fails timely and actively to assume or to continue to assume
the defense of such claim, then the Indemnifying Party shall not have the right to direct the defense of such claim or litigation on behalf of the Indemnified Party and the Indemnified Party shall have the right to employ one separate counsel at the
Indemnifying Party’s expense. The failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Section 2, except to the extent that such failure to give notice
shall materially adversely affect the Indemnifying Party in the defense of any such claim or any such litigation. No Indemnifying Party, in the defense of any claim or litigation, shall, without the consent of the Indemnified Party, consent to entry
of any judgment or enter into any settlement that does not include, as an unconditional term, the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect of such third party claim or litigation. In no
event shall an Indemnified Party consent to any entry of any judgment in a third party claim or litigation, or settle a third party claim or litigation without the prior written consent of the Indemnifying Party (which shall not be unreasonably
withheld or delayed) 

  
 11 

 
unless the Indemnifying Party fails to timely give notice of its intention to assume defense or timely and actively to assume and continue such defense. 

(d) In order to provide for just and equitable contribution to joint liability under the 1933 Act in any case in which
either (i) any Holder exercising rights under this Agreement, or any controlling person of any such Holder, makes a claim for indemnification pursuant to this Section 2.6 but it is judicially determined (by the entry of a final judgment or
decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case notwithstanding the fact that this Section 2.6 provides for
indemnification in such case, or (ii) contribution under the 1933 Act may be required on the part of any such Holder or any such controlling person in circumstances for which indemnification is provided under this Section 2.6; then, and in
each such case, the Company and such Holder will contribute to the amount paid or payable by such Indemnified Party as a result of such aggregate claims, losses, damages or liabilities in such proportion as is appropriate to reflect the relative
fault of the Indemnifying Party and Indemnified Party in connection with the actions which resulted in such aggregate claims, losses, damages or liabilities, as well as any other relevant equitable considerations, including the relative benefits
received from the offering. The relative faults of such Indemnifying Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material
fact or omission or alleged omission to state a material fact, has been made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties’ relative intent, knowledge, access to information and
opportunity to correct or prevent such action. Notwithstanding any of the foregoing, in any case, (A) no such Holder will be required to contribute any amount in excess of the net proceeds (after deducting the underwriters’ discounts and
commissions) received by such Holder in the offering and (B) no person or entity guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) will be entitled to contribution from any person or entity who
was not guilty of such fraudulent misrepresentation. 
 (e) The indemnities provided in this Section 2.6
shall survive the transfer of any Registrable Securities by such Holder. 
 2.7 Information by Holder. The Holder or
Holders of Registrable Securities included in any registration shall furnish to the Company such information regarding such Holder or Holders and the distribution proposed by such Holder or Holders as the Company may reasonably request in writing
and as shall be required in connection with any registration, qualification or compliance referred to in this Section 2. 

2.8 Transfer and Assignment of Rights. The rights contained in Section 2 hereof may be assigned or otherwise conveyed in
whole or in part together with a transfer or assignment of shares of Registrable Securities and the transferee of such Registrable Securities shall be considered a “Holder” for purposes of this Agreement; provided, that, in order to effect
such a transfer of rights (i) the transferee must be recipient of at least 0.5% of the total number of shares of Registrable Securities held by all 

  
 12 

 
Holders and (ii) the transferee must agree to be bound by the obligations of this Agreement. Any such transferee may again transfer such rights in accordance with the terms of this
Agreement. 
 2.9 Form S-3. 
 (a) The Company shall use its best efforts to qualify for registration on Form S-3 (or any future form that is substantially equivalent to the current Form S-3) as soon as it is eligible. After the
Company has qualified for the use of Form S-3, the Holders of at least twenty percent (20%) of the then-outstanding Registrable Securities shall have the right to request registrations on Form S-3 thereafter under this Section 2.9. The
Company shall give notice to all Holders of Registrable Securities of the receipt of a request for registration pursuant to this Section 2.9 and shall provide a reasonable opportunity for other Holders to participate in the registration.
Subject to the foregoing, the Company will use its best efforts to effect as soon as practicable, and in any event within ninety (90) days, the registration of all shares of Registrable Securities on Form S-3 to the extent requested by the
Holder or Holders thereof for purposes of disposition; provided, however, that the Company shall not be obligated to effect any such registration if the Holders, together with the holders of any other securities of the Company entitled to inclusion
in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than $1,000,000. All expenses incurred in connection with a registration requested pursuant to this
Section 2.9, including (without limitation) all registration, filing, qualification, printers’ and accounting fees and the reasonable fees and disbursements of one counsel for the selling Holder or Holders and counsel for the Company, but
excluding any underwriters’ discounts or commissions associated with Registrable Securities, shall be borne by the Company in accordance with Section 2.4. Registrations effected pursuant to this Section 2.9 shall not be counted as
registrations or demands for registration effected pursuant to Sections 2.2 and 2.3. Notwithstanding the foregoing, nothing herein shall restrict, prohibit or limit in any way a Holder’s ability to exercise its registration rights under
Sections 2.2 or 2.3 hereof. The Company may delay registration pursuant to this Section 2.9 to the extent of the provisions of Section 2.2(a)(ii) (B) (which shall be deemed to apply to the obligations under this Section 2.9 with
equal force). 
 (b) If the Holders requesting registration on Form S-3 pursuant to this Section 2.9 so
request, the Registrable Securities covered by such Form S-3 shall be distributed by means of an underwriting upon the same terms and conditions as an underwritten distribution pursuant to Section 2.2(b) hereof. 

2.10 Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any
such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 
 2.11 Limitations on Subsequent Registration Rights. From and after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least sixty-six and
two-thirds percent (66 2/3%) of the Registrable Securities then outstanding and not registered, enter into any agreement with any holder or prospective holder of any securities of the Company that

  
 13 

 
would allow such holder or prospective holder to (a) require the Company to effect a registration, or (b) include any securities in any registration filed under Section 2.2, 2.3 or
2.9 hereof. 
 2.12 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and
regulations of the SEC that may at any time permit the sale of the Registrable Securities to the public without registration or pursuant to a registration on Form S-3, the Company agrees to use its diligent efforts to: 

(a) make and keep public information available, as those terms are understood and defined in SEC Rule 144, at all times
after ninety (90) days after the effective date of the first registration statement filed by the Company for the offering of its securities to the general public so long as the Company remains subject to the periodic reporting requirements
under Sections 13 or 15(d) of the 1934 Act; 
 (b) take such action, including the voluntary registration of its
Common Stock under Section 12 of the 1934 Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of their Registrable Securities, such action to be taken as soon as practicable after the end of the fiscal year in which the
first registration statement filed by the Company for the offering of its securities to the general public is declared effective; 
 (c) file with the SEC in a timely manner all reports and other documents required of the Company under the 1933 Act and the 1934 Act; and 

(d) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) a
written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement filed by the Company), the 1933 Act and the
1934 Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies), (ii) a copy of the most recent
annual or quarterly report of the Company and such other reports and documents so filed by the Company, and (iii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC which permits
the selling of any such securities without registration or pursuant to such form. 
 2.13 Market Stand-Off Agreement.
Each Holder hereby agrees that during a period, not to exceed one hundred and eighty (180) days following the effective date of an effective registration statement of the Company filed under the 1933 Act, it shall not, to the extent requested
by the Company and any underwriter, sell, pledge, transfer, make any short sale of, loan, grant any option for the purchase of, or otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any Common Stock held by it at
any time during such period except Common Stock included in such registration, and each Holder further agrees to execute such agreements as may be reasonably requested by the underwriters that are consistent with this Section 2.13 or that are
necessary to give further effect thereto; provided, however, that all “One Percent Holders” (as defined below) and all officers and directors of the Company enter into similar agreements. For purposes of this

  
 14 

 
Agreement, the term “One Percent Holder” shall mean a Holder who owns at least one percent (1%) of the outstanding Common Stock of the Company (assuming conversion of any
outstanding preferred stock of the Company) at the time of the proposed transfer of Common Stock. Any such agreement shall be in a form satisfactory to the Holders of a majority of the Registrable Securities. Neither the Company nor the underwriter
shall amend, terminate or waive any such agreement unless each “market stand-off” agreement with each Holder is also amended or waived in a similar manner or terminated, as the case may be. In order to enforce the foregoing covenant, the
Company may impose stop transfer instructions with respect to the securities held by each Holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 

2.14 Termination of Rights. The rights of any particular Holder under this Section 2 shall terminate as to any Holder on the
date that is seven (7) years after the closing of the Company’s initial public offering. 
 SECTION 3.

 MISCELLANEOUS 
 3.1 Governing Law. This Agreement shall be governed by, and construed and interpreted in accordance with the laws of the State of Delaware, excluding its conflict of laws principles. 

3.2 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of,
and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. 
 3.3 Entire
Agreement. This Agreement constitutes the full and entire understanding and agreement among the parties with regard to the subjects hereof. Nothing in this Agreement, express or implied, is intended to confer upon any party, other than the
parties hereto and their successors and assigns, any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided herein. Upon the effectiveness of this Agreement, all prior agreements pursuant to
which Cempra Holdings, LLC or Cempra Pharmaceuticals, Inc. provided registration rights to the Holders shall be deemed amended and restated and superseded and replaced in their entirety by this Agreement and of no further force or effect.

 3.4 Severability. Any invalidity, illegality or limitation of the enforceability with respect to any Holder of any one
or more of the provisions of this Agreement, or any part thereof, shall in no way affect or impair the validity, legality or enforceability of this Agreement with respect to any other Holder. In case any provision of this Agreement shall be invalid,
illegal or unenforceable, it shall to the extent practicable, be modified so as to make it valid, legal and enforceable and to retain as nearly as practicable the 

  
 15 

 
intent of the parties, and the validity, legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

3.5 Amendment and Waiver. Except as otherwise expressly provided herein, any term of this Agreement may be amended and the
observance of any term of this Agreement may be waived (either generally or in a particular instance, either retroactively or prospectively and either for a specified period of time or indefinitely) with the written consent of the Company and the
Holders, or their transferees, holding at least sixty-six and two-thirds percent (66 2/3%) of the shares of Common Stock held by such Holders at the effective time of this Agreement, voting together as a single group. Any amendment or waiver
effected in accordance with this Section 3.5 shall be binding upon the Company, each Holder and each transferee of the Registrable Securities. Upon the effectuation of each such amendment or waiver, the Company shall promptly give written
notice thereof to the Holders who have not previously consented thereto in writing. Notwithstanding anything to the contrary in this Section 3.5, the Company shall be entitled to grant the registration rights set forth herein to any person who
had registration rights under the LLC Agreement as a shareholder of Cempra Holdings, LLC, but failed to execute this Agreement prior to its effective time. Such grant of registration rights shall be made by the Company obtaining a counterpart
signature page hereto and amending Exhibit A hereto with the name of the additional Holder. 
 3.6 Delays or
Omissions. No delay or omission to exercise any right, power or remedy accruing to the Company, the Holders, or any transferees upon any breach, default or noncompliance of the Holders or any transferee or the Company under this Agreement, shall
impair any such right, power or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed
that any waiver, permit, consent or approval of any kind or character on the part of the Company or the Holders of any breach, default or noncompliance under this Agreement or any waiver on the Company’s or the Holders’ part of any
provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing and that all remedies, either under this Agreement, by law, or otherwise afforded to the Company and the
Holders, shall be cumulative and not alternative. 
 3.7 Notices, etc. Any notice required or permitted under this
Agreement shall be given in writing and shall be deemed effectively given and received: (a) upon personal delivery to the party to be notified; (b) upon delivery by confirmed facsimile transmission if received by the recipient before 5:00
p.m. local time on a business day, and if not, then the next business day; (c) if to a U.S. resident, five (5) days after deposit with the United States Post Office, by registered or certified mail, postage prepaid; or (d) if to a
U.S. resident, one (1) business day after deposit with a nationally recognized overnight courier service (or if to a non-U.S. resident, two (2) business days after deposit with an internationally recognized overnight courier service,
specifying international priority delivery), and addressed: 

  
 16 

	 	(a)	if to the Company, at: 

 Cempra,
Inc. 
 6340 Quadrangle Drive 
 Suite 100 
 Chapel Hill, NC 27517 

Attn: Prabhavathi Fernandes 
 Telephone: (919) 467-1716 
 Facsimile: (919) 481-1063 

With a copy to: 

Wyrick Robbins Yates & Ponton LLP 
 4101 Lake Boone Trail, Suite 300 
 Raleigh, NC 27607 

Attn: Kenneth Eheman 
 Telephone: (919) 781-4000 
 Facsimile: (919) 781-4865 

or at such other address as the Company shall have furnished to the Holders in writing; 

(b) if to the Holders, at the addresses of such Holders specified on Exhibit A hereto, or at such other address as
the Holders shall have furnished to the Company in writing; and 
 (c) if to a Holder, at such Holder’s
address as shall have been furnished to the Company in writing. 
 3.8 Titles and Subtitles. The titles and subtitles of
sections and subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
 3.9 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

 3.10 Further Assurances. Each party hereto agrees to execute and deliver, by the proper exercise of its corporate,
limited liability company, partnership or other powers, all such other additional instruments and documents and do all such other acts and things as may be reasonably necessary to more fully effectuate this Agreement. 

[The next page is the signature page.] 

  
 17 

 IN WITNESS WHEREOF, this Registration Rights Agreement has been duly executed and delivered
by the parties as of the date first above written. 
  

									
	THE COMPANY:	 		 	CEMPRA, INC.
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	Prabhavathi Fernandes, Ph.D.
		 		 		 	Title:	 	President and Chief Executive Officer
			
	THE HOLDERS:	 		 	I. WISTAR MORRIS, III
			
		 		 	 
		 		 	I. Wistar Morris, III
			
		 		 	COTSWOLD FOUNDATION
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	ELEVENTH GENERATION PARTNERSHIP, LP
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	MARTHA H. MORRIS
				
		 		 		 	 
		 		 		 	Martha H. Morris

									
		 		 	INTERSOUTH PARTNERS VI, L.P.
				
		 		 	By:	 	 Intersouth Associates VI, LLC,
 its General Partner

					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	INTERSOUTH PARTNERS VII, LP
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	DAL LAMAGNA
				
		 		 		 	 
		 		 		 	Dal LaMagna
			
		 		 	JOSH MAILMAN
			
		 		 	 
		 		 	Josh Mailman
			
		 		 	 PETER BAUMANN & ALISON BAUMANN,
 JOINT TENANTS

			
		 		 	 
		 		 	Peter Baumann
			
		 		 	 
		 		 	Alison Baumann

									
		 		 	KIMBERLY SEIBERT
				
		 		 		 	 
		 		 		 	Kimberly Seibert
			
		 		 	 GERALD LIHOTA & KARLA LIHOTA,
 JOINT TENANTS

				
		 		 		 	 
		 		 		 	Gerald Lihota
				
		 		 		 	 
		 		 		 	Karla Lihota
			
		 		 	WILLIAM J. LEAHY IRA ROLLOVER
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	BIONAPLES, LLC
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	HANS H. LIU, M.D.
				
		 		 		 	 
		 		 		 	Hans H. Liu, M.D.
			
		 		 	DEAN OLMSTEAD
				
		 		 		 	 
		 		 		 	Dean Olmstead

									
			
		 		 	MARTHA COONLEY
				
		 		 		 	 
		 		 		 	Martha Coonley
			
		 		 	HOWARD COONLEY
				
		 		 		 	 
		 		 		 	Howard Coonley
			
		 		 	 MARY KATHERINE HITCHNER &
 ELAM M. HITCHNER, JOINT TENANTS

				
		 		 		 	 
		 		 		 	Mary Katherine Hitchner
				
		 		 		 	 
		 		 		 	Elam M. Hitchner
			
		 		 	JOHN LOONEY IRA
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	KATHERINE C. KELLEY
				
		 		 		 	 
		 		 		 	Katherine C. Kelley
			
		 		 	HUNT- BIOVENTURES, L.P.
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 

									
		 		 	AISLING CAPITAL II, LP
				
		 		 	By:	 	 
		 		 		 	Its General Partner
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	BLACKBOARD VENTURES INC.
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	QUAKER BIOVENTURES II, LP
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	DEVON PARK BIOVENTURES, LP
					
		 		 		 	By:	 	 
		 		 		 	Name:	 	 
		 		 		 	Title:	 	 
			
		 		 	JOHN LOONEY
				
		 		 		 	 
		 		 		 	John Looney

 Exhibit A 

Holders 
 I. Wistar
Morris, III 
 234 Broughton Lane 

Villanova, PA 19085 
 Cotswold Foundation,
Wistar Morris and Martha Morris, Trustees 
 234 Broughton Lane 
 Villanova, PA 19085 
 Eleventh Generation Partnership, LP 

Attn: Martha Morris, Power of Attorney 
 234
Broughton Lane 
 Villanova, PA 19085 

Martha H. Morris 
 234 Broughton Lane

 Villanova, PA 19085 
 Intersouth
Partners VI, L.P. 
 406 Blackwell Street 
 Suite 200 
 Durham, NC 27701 
 Attn: Richard Kent 
 Aisling Capital II, LP 

888 Seventh Ave. 
 30th Floor 
 New York, NY 10106 
 Dal LaMagna 
 2020 Lutes Road, N.W. 
 Poulsbo, WA 98370 
 Joshua Mailman 
 1 West 67th Street 
 New York, NY 10023 
 Peter Baumann & Alison Baumann, Joint Tenants 

2100 Pacific Avenue 
 San Francisco, CA 94115

 Kimberly Seibert 
 2323 Race Street, Unit 1102 
 Philadelphia, PA 19103 

Gerald Lihota & Karla Lihota, Joint Tenants 
 39 Langstoon Lane 
 Media, PA 19063-1150 
 William J. Leahy IRA Rollover (#5096-6984) 
 37 Dorchester Lane 

Richboro, PA 18954 
 Issued to: First Clearing,
LLC as custodian fbo William J. Leahy IRA Rollover 
 Katherine C. Kelley 
 PO Box 1048 
 Athens, OH 45701-1048 
 Bionaples, LLC 
 Attention: Mr. Robin Gadsby 

c/o Gap Financial Counseling Corporation 
 5801
Pelican Bay Blvd. 
 Suite 600 
 Naples
FL 34108 
 Hans H. Liu, M.D. 
 219
Garnet Lane 
 Bala Cynwyd, PA 19004-1313 
 Dean Olmstead 
 2572 13th Avenue, W. 
 Seattle, WA 98119 
 Martha Coonley 
 109 Church Street 
 Philadelphia, PA 19106 

Mary Katherine Hitchner & Elam M. Hitchner, Joint Tenants 
 PO Box 335 
 Haverford, PA 19041 
 Howard Coonley 
 109 Church Street 
 Philadelphia, PA 19464 

 John Looney IRA 
 11 Surrey Lane 
 Durham, NC 27707 
 Issued to: FCC as Custodian FBO John Looney IRA 5160-3240 
 Blackboard Ventures Inc. 

c/o Ontario Teachers’ Pension Plan Board 

5650 Yonge Street 
 Toronto, Ontario M2M 4H5

 Intersouth Partners VII, L.P. 
 406
Blackwell Street 
 Suite 200 
 Durham,
NC 27701 
 Attn: Richard Kent 
 Quaker
BioVentures II, L.P. 
 Cira Centre 

2929 Arch Street 
 Philadelphia, PA 19104

 Attn: Brenda D. Gavin, D.V.M. 

Devon Park Bioventures, L.P. 
 1400 Liberty
Ridge Drive, Suite 103 
 Wayne, PA 19087 
 Attn: Devang V. Kantesaria, M.D. 
 John Looney 

11 Surrey Lane 
 Durham, NC 27707 

Hunt - BioVentures, L.P 
 1900 North Akard
Street 
 Dallas, TX 75201-2300 
 Attn:
Michael T. Bierman, Managing Director

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