Document:

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                                                                  Exhibit 10.1.1

                                 METABOLIX, INC.

                        INCENTIVE STOCK OPTION AGREEMENT

     Metabolix, Inc., a Delaware corporation (the "Company"), hereby grants
as of [Grant Date] (the "Grant Date") to [First Name] [Last Name] (the
"Employee"), an option to purchase a maximum of [Shares] shares (the "Option
Shares") of its Common Stock, $.01 par value ("Common Stock"), at the price
of [Price] per share on the following terms and conditions:

     1.   GRANT UNDER THE 1995 STOCK PLAN OF METABOLIX, INC. This option is
granted pursuant to and is governed by the 1995 Stock Plan of Metabolix, Inc.,
(the "Plan") and, unless the context otherwise requires, terms used herein shall
have the same meaning as in the Plan. Determinations made in connection with
this option pursuant to the Plan shall be governed by the Plan as it exists on
this date.

     2.   GRANT AS INCENTIVE STOCK OPTION: OTHER OPTIONS. This option is
intended to qualify as an incentive stock option under Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"). This option is in
addition to any other options heretofore or hereafter granted to the Employee by
the Company or any Related Corporation (as defined in the Plan), but a duplicate
original of this instrument shall not effect the grant of another option.

     3.   VESTING OF OPTION IF EMPLOYMENT CONTINUES. If the Employee has
continued to be employed by the Company or any Related Corporation on the
following dates, the Employee may exercise this option for the number of shares
of Common Stock set opposite the applicable date:

<Table>
     <S>                                        <C>
     Less than one year from               -    ___ shares
     [Vesting Date]

     One year but less than                -    ___ shares
     two years from [Vesting Date]

     Two years but less than               -    an additional
     three years from [Vesting Date]            ___ shares

     Three years but less than             -    an additional
     four years from [Vesting Date]             ___ shares

     Four years or more from               -    an additional
     [Vesting Date]                             ___ shares
</Table>

The foregoing rights are cumulative and, while the Employee continues to be
employed by the Company or any Related Corporation, may be exercised on or
before the date which is ten years from the date this option is granted. All of
the foregoing rights are subject to Sections 4 and 5, as appropriate, if the
Employee ceases to be employed by the Company and all Related Corporations.

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                                       -2-

     4.   TERMINATION EMPLOYMENT.

          (a)  TERMINATION: If the Employee ceases to be employed by the Company
and all Related Corporations, other than by reason of death or disability as
defined in Section 5, no further installments of this option shall become
exercisable, and this option shall terminate after the passage of sixty (60)
days from the Employee's last day of employment, but in no event later than the
scheduled expiration date. In such a case, the Employee's only rights hereunder
shall be those winch are properly exercised before the termination of this
option.

     5.   DEATH; DISABILITY.

          (a)  DEATH: If the Employee dies while in the employ of the Company
or any Related Corporation, this option may be exercised, to the extent
otherwise exercisable on the date of his or her death, by the Employee's estate,
personal representative or beneficiary to whom this option has been assigned
pursuant to Section 10, at any time within 180 days after the date of death, but
not later than, the scheduled expiration date.

          (b)  DISABILITY: If the Employee ceases to be employed by the Company
and all Related Corporations by reason of his or her disability (as defined in
the Plan), this option may be exercised, to the extent otherwise exercisable on
the date of the termination of his or her employment, at any time within 180
days after such termination, but not later than the scheduled expiration date.

          (c)  EFFECT OF TERMINATION; At the expiration of the 180-day period
provided in paragraph (a) or (b) of this Section 5 or the scheduled expiration
date, whichever is the earlier, this option shall terminate and the only rights
hereunder shall be those as to which the option was properly exercised before
such termination.

     6.   PARTIAL EXERCISE. This option may be exercised in part at any time and
from time to time within the above limits, except that this option may not be
exercised for a fraction of a share unless such exercise is with respect to the
final installment of stock subject to this option and cash in lieu of a
fractional share must be paid, in accordance with Paragraph 13(G) of the Plan,
to permit the Employee to exercise completely such final installment. Any
fractional share with respect to which an installment of this option cannot be
exercised because of the limitation contained in the preceding sentence shall
remain subject to this option and shall be available for later purchase by the
Employee in accordance with the terms hereof.

     7.   PAYMENT OF PRICE. The option price shall be paid in United States
dollars in the following manner:

          (a)  in cash or by check, or any combination of the foregoing, equal
     in amount to the option price; or

          (b)  in the discretion of the Company's Board of Directors, in cash,
     by check, by delivery of shares of the Company's Common Stock having a fair
     market value (as determined by the Board of Directors) equal as of the date
     of exercise to the option price, or by any combination of the foregoing,
     equal in amount to the option price.

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                                       -3-

     Notwithstanding the foregoing, the Employee may not pay any part of the
exercise price hereof by transferring Common Stock to the Company if such
Company's Common Stock is both subject to a substantial risk of forfeiture and
not transferable within the meaning of Section 83 of the Code.

     8.   RESTRICTIONS ON RESALE. Option Shares may not be transferred without
the Company's written consent except by will, by the laws of descent and
distribution and in accordance with the provisions of Sections 17 and 18, if
applicable. Option Shares will be of an illiquid nature and will be deemed to be
"restricted securities" for purposes of the Securities Act of 1933, as amended.
Accordingly, such shares must be sold in compliance with the registration
requirements of such Act or an exemption therefrom.

     9.   METHOD OF EXERCISING OPTION. Subject to the terms and conditions of
this Agreement, this option may be exercised by written notice to the Company at
its principal executive office, or to such transfer agent as the Company shall
designate. Such notice shall state the election to exercise this option and the
number of Option Shares for which it is being exercised and shall be signed by
the person or persons so exercising this option. Such notice shall be
accompanied by payment of the full purchase price of such shares (as provided in
Section 7 hereof), and the Company shall deliver a certificate or certificates
representing such shares as soon as practicable after the notice shall be
received. Such certificate or certificates shall be registered in the name of
the person or persons so exercising this option (or, if this option shall be
exercised by the Employee and if the Employee shall so request in the notice
exercising this option, shall be registered in the name of the Employee and
another person jointly, with right of survivorship). In the event this option
shall be exercised, pursuant to Section 5 hereof, by any person or persons other
than the Employee, such notice shall be accompanied by appropriate proof of the
right of such person or persons to exercise this option.

     10.  OPTION NOT TRANSFERABLE. This option is not transferable or assignable
except by will or by the laws of descent and distribution. During the Employee's
lifetime only the Employee can exercise this option.

     11.  NO OBLIGATION TO EXERCISE OPTION. The grant and acceptance of this
option imposes no obligation on the Employee to exercise it.

     12.  NO OBLIGATION TO CONTINUE EMPLOYMENT. Neither the Plan, this
Agreement, nor the grant of this option imposes any obligation on the Company or
any Related Corporation to continue the Employee in employment.

     13.  NO RIGHTS AS STOCKHOLDER UNTIL EXERCISE. The Employee shall have no
rights as a stockholder with respect to the Option Shares until such time as the
Employee has exercised this option by delivering a notice of exercise and has
paid in full the purchase price for the shares so exercised in accordance with
Section 9. Except as is expressly provided in the Plan with respect to certain
changes in the capitalization of the Company, no adjustment shall be made for
dividends or similar rights for which the record date is prior to such date of
exercise.

     14.  CAPITAL CHANGES AND BUSINESS SUCCESSIONS. The Plan contains provisions
covering the treatment of options in a number of contingencies such as stock
splits and mergers. Provisions in the Plan for adjustment with respect to stock
subject to options and the related provisions with respect to successors to the
business of the Company are hereby made applicable hereunder and are
incorporated herein by reference. The Option Shares shall include all shares
issued in connection with such provisions.

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                                       -4-

     15.  EARLY DISPOSITION. The Employee agrees to notify the Company in
writing immediately after the Employee transfers any Option Shares, if such
transfer occurs on or before the later of (a) the date two years after the date
of this Agreement or (b) the date one year after the date the Employee acquired
such Option Shares. The Employee also agrees to provide the Company with any
information concerning any such transfer required by the Company for tax
purposes.

     16.  WITHHOLDING TAXES. If the Company or any Related Corporation in its
discretion determines that it is obligated to withhold any tax in connection
with the exercise of this option, or in connection with the transfer of, or the
lapse of restrictions on, any Common Stock or other property acquired pursuant
to this option, the Employee hereby agrees that the Company or any Related
Corporation may withhold from the Employee's wages or other remuneration the
appropriate amount of tax. At the discretion of the Company or Related
Corporation, the amount required to be withheld may be withheld in cash from
such wages or other remuneration or in kind from the Common Stock or other
property otherwise deliverable to the Employee on exercise of this option. The
Employee further agrees that, if the Company or any Related Corporation does not
withhold an amount from the Employee's wages or other remuneration sufficient to
satisfy the withholding obligation of the Company or Related Corporation, the
Employee will make reimbursement on demand, in cash, for the amount
underwithheld.

     17.  COMPANY'S RIGHT OF FIRST REFUSAL.

          (a)  EXERCISE OF RIGHT: If the Employee desires to transfer all or any
part of the Option Shares to any person other than the Company (an "Offeror"),
the Employee shall: (i) obtain in writing an irrevocable and unconditional bona
fide offer (the "Offer") for the purchase thereof from the Offeror; and (ii)
give written notice (the "Option Notice") to the Company setting forth the
Employee's desire to transfer such shares, which Option Notice shall be
accompanied by a photocopy of the Offer and shall set forth at least the name
and address of the Offeror and the price and terms of the Offer. Upon receipt of
the Option Notice, the Company shall have an assignable option to purchase any
or all of such Option Shares (the "Company Option Shares") specified in the
Option Notice, such option to be exercisable by giving, within 30 days after
receipt of the Option Notice, a written counter-notice to the Employee. If the
Company elects to purchase any or all of such Company Option Shares, it shall be
obligated to purchase, and the Employee shall be obligated to sell to the
Company, such Company Option Shares at the price and terms indicated in the
Offer within 30 days from the date of delivery by the Company of such
counter-notice.

          (b)  SALE OF OPTION SHARES TO OFFEROR: The Employee may, for 60 days
after the expiration of the 30-day option period as set forth in Section 17(a),
sell to the Offerer, pursuant to the terms of the Offer, any or all of such
Company Option Shares not purchased or agreed to be purchased by the Company or
its assignee; PROVIDED, HOWEVER, that the Employee shall not sell such Company
Option Shares to such Offeror if such Offeror is a competitor of the Company and
the Company gives written notice to the Employee, within 30 days of its receipt
of the Option Notice, stating that the Employee shall not sell his or her
Company Option Shares to such Offeror; and PROVIDED, FURTHER, that prior to the
sale of such Option Shares to an offerer, such Offeror shall execute an
agreement with the Company pursuant to which such Offeror agrees to be subject
to the restrictions set forth in this Section 17. If any or all of such Company
Option Shares are not sold pursuant to an Offer within the time permitted above,
the unsold Company Option Shares shall remain subject to the terms of this
Section 17.

          (c)  ADJUSTMENTS FOR CHANGES IN CAPITAL STRUCTURE: If there shall be
any change in the Common Stock of the Company through merger, consolidation,
reorganization, recapitalization,

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                                       -5-

stock dividend, stock split, combination or exchange of shares, or the like, the
restrictions contained in this Section 17 shall apply with equal force to
additional and/or substitute securities, if any, received by the Employee in
exchange for, or by virtue of his or her ownership of, Option Shares.

          (d)  FAILURE TO DELIVER OPTION SHARES: If the Employee fails or
refuses to deliver on a timely basis duly endorsed certificates representing
Company Option Shares to be sold to the Company or its assignee pursuant to this
Section 17, the Company shall have the right to deposit the purchase price for
such Company Option Shares in a special account with any bank or trust company
in the Commonwealth of Massachusetts, giving notice of such deposit to the
Employee, whereupon such Company Option Shares shall be deemed to have been
purchased by the Company. All such monies shall he held by the bank or trust
company for the benefit of the Employee. All monies deposited with the bank or
trust company but remaining unclaimed for two years after the date of deposit
shall be repaid by the bank or trust company to the Company on demand, and the
Employee shall thereafter look only to the Company for payment. The Company may
place a legend on any certificate for Option Shares delivered to the Employee
reflecting the restrictions on transfer provided in Section 8 hereof and this
Section 17,

          (e)  EXPIRATION OF COMPANY'S RIGHT OF FIRST REFUSAL: The first refusal
rights of the Company set forth above shall remain in effect until such time, if
ever, as a distribution to the public is made of shares of the Company's Common
Stock pursuant to a registration statement filed under the Securities Act of
1933, as amended, or a successor statute, at which time the refusal rights of
the Company set forth herein will automatically expire.

     18.  COMPANY'S RIGHT OF REPURCHASE.

          (a)  RIGHT OF REPURCHASE. The Company shall have the right (the
"Repurchase Right") to repurchase all of the Option Shares from the holder of
this option upon the occurrence of any of the events specified in Section 18(b)
below (the "Repurchase Event"). The Repurchase Right may be exercised by the
Company within 60 days following the later of the date of the exercise of this
option or the date the Company receives actual knowledge of such event (the
"Repurchase Period"). The Repurchase Right shall be exercised by the Company by
giving the holder written notice on or before the last day of the Repurchase
Period of its intention to exercise the Repurchase Right, and, together with
such notice, tendering to the holder an amount equal to the greater of the
option price or the fair market value of the shares. The Company may assign the
Repurchase Right to one or more persons. Upon timely exercise of the Repurchase
Right in the manner provided in this Section 18(a), the holder shall deliver to
the Company the stock certificate or certificates representing the shares being
repurchased, duly endorsed and free and clear of any and all liens, charges and
encumbrances.

     If shares are not purchased under the Repurchase Right, the Employee and
his or her successor in interest, if any, will hold any such shares in his or
her possession subject to all of the provisions of tin's Agreement.

          (b)  COMPANY'S RIGHT TO EXERCISE REPURCHASE RIGHT: The Company shall
have the Repurchase Right in the event that any of the following events shall
occur:

               (i)    The termination of the Employee's employment with the
     Company and all Related Corporations, voluntarily or involuntarily, for any
     reason whatsoever including death or permanent disability;

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                                       -6-

               (ii)   The receivership, bankruptcy or other creditor's
     proceeding regarding the Employee or the taking of any of Employee's shares
     acquired upon exercise of tins option by legal process, such as a levy of
     execution; or

               (iii)  Distribution of shares held by the Employee to his or her
     spouse as such spouse's joint or community interest pursuant to a decree of
     dissolution, operation of law, divorce, property settlement agreement or
     for any other reason, except as may be otherwise permitted by the Company.

          (c)  DETERMINATION OF FAIR MARKET VALUE: The fair market value of the
Option Shares shall be, for purposes of this Section 18, determined in
accordance with Section 6D of the Plan as of the date of the Repurchase Event.
The determination by the Board of Directors of the fair market value shall be
conclusive and binding.

          (d)  EXPIRATION OF COMPANY'S REPURCHASE RIGHT: The Repurchase Right
shall remain in effect until such time, if ever, as (i) the Option Shares are
transferred in accordance with Section 17 hereof or (ii) a distribution to the
public is made of shares of the Company's Comrnon Stock pursuant to a
registration statement filed under the Securities Act of 1933, as amended, or
any successor statute.

     19.  LOCK-UP AGREEMENT. The Employee agrees that in connection with an
underwritten public offering of Common Stock, upon the request of the Company or
the principal underwriter managing such public offering, this Option and the
Option Shares may not be sold, offered for sale or otherwise disposed of without
the prior written consent of the Company or such underwriter, as the case may
be, for at least 180 days after the effectiveness of the Registration Statement
filed in connection with such offering, or such longer period of time as the
Board of Directors may determine if all of the Company's directors and officers
agree to be similarly bound. The lock-up agreement established pursuant to this
paragraph 19 shall have perpetual duration.

     20.  PROVISION OF DOCUMENTATION TO EMPLOYEE. By signing this Agreement the
Employee acknowledges receipt of a copy of this Agreement and a copy of the
Plan.

     21.  MISCELLANEOUS.

          (a)  NOTICES: All notices hereunder shall be in writing and shall be
deemed given when sent by certified or registered mail, postage prepaid, return
receipt requested, to the address set forth below. The addresses for such
notices may be changed from time to time by written notice given in the manner
provided for herein.

          (b)  ENTIRE AGREEMENT; MODIFICATION: This Agreement constitutes the
entire agreement between the parties relative to the subject matter hereof, and
supersedes all proposals, written or oral, and all other communications between
the parties relating to the subject matter of this Agreement. This Agreement
may be modified, amended or rescinded only by a written agreement executed by
both parties.

          (c)  SEVERABILITY: The invalidity, illegality or unenforceability of
any provision of this Agreement shall in no way affect the validity, legality or
enforceability of any other provision.

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                                       -7-

          (d)  SUCCESSORS AND ASSIGNS: This Agreement shall be binding upon and
inure to the benefit of the parties hereto and their respective successors and
assigns, subject to the limitations set forth in Section 10 hereof.

          (c)  GOVERNING LAW: This Agreement shall be governed by and
interpreted in accordance with the laws of the Commonwealth of Massachusetts
without giving effect to the principles of the conflicts of laws thereof.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

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                                       -8-

     IN WITNESS WHEREOF, the Company and the Employee have caused this
instrument to be executed as of the date first above written.

                                      METABOLIX, INC.
------------------------------        303 Third Street
Employee                              Cambridge, MA 02142-1196

                                       By:
------------------------------            -----------------------------------
Print Name of Employee                    James Barber
                                          President and Chief Executive Officer

------------------------------
Street Address

------------------------------
City   State      Zip Code<Page>

                                                                   Exhibit 10.23

METABOLIX
where nature performs(TM) [LOGO]

[LOGO]

                                         21 Erie Street
                                         Cambridge, Massachusetts 02139-4260 USA
                                         Tel: 617.492.0505 . Fax: 617-492-1996
                                         Web: www.metabolix.com

                                       August 29, 2006

Brian Igoe
44 Oak Street
Weston, MA 02493

     Re: EMPLOYMENT AGREEMENT

Dear Brian:

     This letter is to confirm our understanding with respect to your employment
by Metabolix, Inc. (the "Company"). The terms and conditions agreed to in this
letter are hereinafter referred to as the "Agreement." In consideration of the
mutual promises and covenants contained in this Agreement, and for other good
and valuable consideration, the receipt and sufficiency of which are hereby
mutually acknowledged, we have agreed as follows:

     1.  EMPLOYMENT.

         (a)    GENERAL. The Company will employ you, and you will be employed
     by the Company, as the Vice President, Chief Brand Officer, of the Company,
     reporting to the Chief Executive Officer, and you shall have the
     responsibilities, duty and authority commensurate with that position. You
     will also perform such other and/or different services for the Company as
     may be assigned to you from time to time. Your employment will commence on
     or about September 1, 2006. You agree that if your employment hereunder
     ends for any reason, you will tender your resignation to the Company of any
     office you may then hold in the Company.

         (b)    DEVOTION TO DUTIES. While you are employed hereunder, you will
     use your best efforts, skills and abilities to perform faithfully all
     duties assigned to you pursuant to this Agreement and will devote your full
     business time and energies to the business and affairs of the Company.
     While you are employed hereunder, you will not undertake any other
     employment from any person or entity without the prior written consent of
     the Company. Notwithstanding the foregoing, nothing contained herein shall
     be deemed to prohibit you from engaging in passive investment or charitable
     activities, so long as they do not interfere with the performance of your
     duties hereunder.

     2.  EMPLOYMENT AT WILL.  Your  employment  hereunder will be on an
"at-will"  basis and may be terminated by the Company or by you at any time for
any reason or for no reason.

<Page>

Brian Igoe
August 29, 2006
Page 2

     3.  COMPENSATION.

         (a)    BASE SALARY. While you are employed hereunder, the Company will
     pay you a base salary at the annual rate of $16,666.67 per month
     (annualized at $200,000.00) (the "Base Salary"). This Base Salary may be
     subject to upward (but not downward) adjustment from time to time in the
     discretion of the Company. The Company will deduct from each monthly salary
     payment all amounts required to be deducted or withheld under applicable
     law or under any employee benefit plan in which you participate.

         (b)    BONUSES.

                (i) In addition to the Base Salary, the Company shall pay you a
     signing bonus of $20,000.00, payable at the same time as your first
     paycheck after commencement of your employment.

                (ii) In addition to the foregoing, the Company on or before
     December 31, 2006, will establish a formalized bonus scheme and pay you an
     annual bonus (a "Bonus") in an amount to be determined by the Company's
     Compensation Committee. The amount will be based on several criteria,
     including the financial condition of the Company and its overall
     performance for the year, but will be strongly influenced by your
     contributions toward the achievement of established corporate goals and
     objectives, as well as other contributions that add recognizable value to
     the Company. The present target for executive bonuses is 50% of Base Salary
     (the "Target Bonus"). This Target Bonus will be subject to revision from
     time to time by the Compensation Committee. In order to receive an annual
     bonus, you must be employed at the time of a timely payment, which will be
     paid on or before March 15 of the year following the year in which it is
     earned.

         (c)    EQUITY COMPENSATION. Upon approval by the Compensation Committee
     of the Company's Board of Directors, the Company shall grant you stock
     options for the purchase of 200,000 shares of the Company's Common Stock at
     an exercise price equal to the fair market value per share of the Common
     Stock on the date of grant. Such stock options shall vest in sixteen (16)
     quarterly installments over a period of four (4) years from the date of
     commencement of your employment. Such options shall be incentive stock
     options to the extent permitted under applicable tax law and regulations.
     In addition, the Company, in the Board's sole discretion, may from time to
     time grant to you stock options, restricted stock or other forms of equity
     compensation pursuant to the Metabolix, Inc. 2005 Stock Plan or any other
     authorized stock plan in effect at the time.

         (d)    VACATION. You will be entitled to five (5) weeks paid vacation
     and paid holidays, accrued and used in accordance with the Company's
     policies as currently in effect. All vacation days will be taken at times
     mutually agreed by you and the Company and will be subject to the business
     needs of the Company.

         (e)    FRINGE BENEFITS. You will be entitled to participate in employee
     benefit plans which the Company provides or may establish for the benefit
     of its senior executives

<Page>

Brian Igoe
August 29, 2006
Page 3

     generally (for example, group life, disability, medical, dental and other
     insurance, retirement, pension, profit-sharing and similar plans)
     (collectively, the "Fringe Benefits"). Your eligibility to participate in
     the Fringe Benefits and receive benefits thereunder will be subject to the
     plan documents governing such Fringe Benefits. Nothing contained herein
     will require the Company to establish or maintain any Fringe Benefits.

     4.  TERMINATION.

         (a)    GENERAL. As an at-will employee, your employment may be
     terminated at any time for any reason or for no reason. Upon termination,
     unless otherwise specifically provided herein, you shall be eligible only
     to receive (i) the portion of your Base Salary as has accrued prior to such
     termination and has not yet been paid, (ii) an amount equal to the value of
     your accrued unused vacation days, and (iii) reimbursement for expenses
     properly incurred by you on behalf of the Company prior to such termination
     if such expenses are properly documented in accordance with Company policy
     and practice and submitted for reimbursement within thirty (30) days of the
     termination date (collectively, the "Accrued Obligations"). Such amounts
     will be paid promptly after termination in accordance with applicable law.

         (b)    TERMINATION WITHOUT CAUSE OR WITH GOOD REASON. Except as
     provided in Section 4(c) hereof, in the event that your employment is
     terminated by the Company without Cause or by you with Good Reason (each,
     as defined below), in addition to the Accrued Obligations, and contingent
     on your provision of a timely and complete release of claims against the
     Company, you shall be entitled to receive continuation of your Base Salary
     in effect at the time of termination for the period of twelve (12) months
     following the termination. To the extent required by Section 409A of the
     Internal Revenue Code of 1986, as amended (the "Code"), the first
     installment of such Base Salary in the amount of six (6) months' Base
     Salary shall be payable on the first business day following the six (6)
     month anniversary of the effective date of termination, and the remainder
     shall be payable in accordance with the Company's regular payroll
     procedures thereafter. If Section 409A of the Code is not then applicable,
     such Base Salary continuation shall commence immediately from the date of
     termination. In addition, should the award of a Bonus have become
     customary, you shall be entitled to a payment equal to the average of the
     Bonuses paid to you (if any) in the two years preceding the termination, to
     be paid (A) on the first business day following the six (6) month
     anniversary of the effective date of termination, to the extent required by
     Section 409A of the Code, or (B) if Section 409A of the Code is not then
     applicable, within thirty (30) days following the termination. In addition
     to the foregoing, you shall be entitled to receive payment of COBRA
     premiums to maintain medical and dental benefits, if any, in effect at the
     time of termination for the period of twelve (12) months following the
     termination.

<Page>

Brian Igoe
August 29, 2006
Page 4

         (c)    TERMINATION WITHOUT CAUSE OR WITH GOOD REASON BEFORE OR AFTER A
     CHANGE OF CONTROL.

                (i) In the event that your employment is terminated by the
     Company without Cause or by you for Good Reason (each, as defined below)
     within the twenty-four (24) month period immediately following or the two
     month period immediately prior to a Change of Control (as defined below),
     in addition to the Accrued Obligations, and contingent on your provision of
     a timely release of claims against the Company, you shall be entitled to
     receive:

                       (A) continuation of your Base Salary in effect at the
     time of  termination  for the period of twelve (12) months following the
     termination. To the extent required by Section 409A of the Code, the first
     installment of such Base Salary in the amount of six (6) months' Base
     Salary shall be payable on the first business day following the six (6)
     month anniversary of the effective date of termination, and the remainder
     shall be payable in accordance with the Company's regular payroll
     procedures thereafter. If Section 409A of the Code is not then applicable,
     such Base Salary continuation shall commence immediately from the date of
     termination.

                       (B) In addition, should the award of a Bonus have become
     customary, you shall be entitled to a payment equal to the average of the
     Bonuses paid to you (if any) in the two years preceding the termination, to
     be paid (A) on the first business day following the six (6) month
     anniversary of the effective date of termination, to the extent required by
     Section 409A of the Code, or (B) if Section 409A of the Code is not then
     applicable, within thirty (30) days following the termination.

                       (C) continued  payment of COBRA premiums to maintain
     medical and dental benefits, if any, in effect at the time of termination
     for the period of twelve (12) months following the termination; and

                       (D) full vesting of all options granted to you under the
     Metabolix Inc. 1995 Stock Plan, the Metabolix Inc. 2005 Stock Plan, or any
     authorized successor stock plan provided that the conditions to vesting
     other than the passage of time have been satisfied.

                (ii) You agree that the payments and benefits hereunder, and
     under all other contracts, arrangements or programs that apply to you (the
     "Company Payments"), shall be reduced to an amount that is one dollar less
     than the amount that would trigger an excise tax under Section 4999 of the
     Code, as determined in good faith by the Company's independent public
     accountants, PROVIDED, HOWEVER, that the reduction shall occur only if the
     reduced Company Payments received by you (after taking into account further
     reductions for applicable federal, state and local income, social security
     and other taxes) would be greater than the unreduced Company Payments to be
     received by you minus (i) the excise tax payable with respect to such
     Company Payments under Section 4999 of the Code; and (ii) all applicable
     federal, state and local income, social security and other

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     taxes on such Company Payments. You and the Company agree to cooperate in
     good faith with each other in connection with any administrative or
     judicial proceedings concerning the existence or amount of golden parachute
     penalties with respect to payments or benefits that you receive.

         (d)    "CAUSE". As used herein, "Cause" shall be defined as (i) your
     conviction for, or plea of nolo contendere, to a felony or a crime
     involving moral turpitude, (ii) your commission of a material act of
     personal dishonesty or a breach of fiduciary duty, in either case,
     involving personal profit in connection with your employment by the
     Company, (iii) your commission of an act which the Board of Directors shall
     reasonably have found to have involved willful misconduct or gross
     negligence on your part in the conduct of your duties under this Agreement,
     (iv) your habitual absenteeism, (v) your material breach of any material
     provision of this Agreement continuing for thirty days after your receipt
     of written notice thereof from the Company, or (vi) the willful and
     continued failure by you to perform substantially your duties with the
     Company (other than any such failure resulting from your incapacity due to
     physical or mental illness).

         (e)    "CHANGE OF CONTROL". As used herein, a "Change of Control" shall
     occur or be deemed to have occurred only upon any one or more of the
     following events:

                (i)    a merger or consolidation of the Company other than a
         merger or consolidation which would result in the voting securities of
         the Company outstanding immediately prior thereto continuing to
         represent (either by remaining outstanding or by being converted into
         voting securities of the surviving entity or the parent of such
         corporation) at least fifty percent (50%) of the total voting power
         represented by the voting securities of the Company or such surviving
         entity or parent of such corporation outstanding immediately after such
         merger or consolidation;

                (ii)   the sale or disposition by the Company of all or
         substantially all of the Company's assets; or

                (iii)  any one person, entity or group, who is not a shareholder
         at time of execution of this Agreement, acquires ownership of capital
         stock of the Company that, together with the capital stock of the
         Company already held by such person, entity or group, constitutes more
         than 50% of the total fair market value or total voting power of the
         capital stock of the Company; provided, however, if any one person,
         entity or group is considered to own more than 50% of the total fair
         market value or total voting power of the capital stock of the Company,
         the acquisition of additional capital stock by the same person, entity
         or group shall not be deemed to be a Change of Control, and further
         provided that the foregoing shall not be deemed a Change of Control if
         the average stock price paid for each share of stock held by the
         person, entity or group is less than $8.00/share (provided that such
         price shall be adjusted as appropriate to reflect any stock

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Brian Igoe
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Page 6

         dividend, stock split, or recapitalization of the Company after the
         date of this agreement).

         (f)    "Good Reason" shall be defined as, in the absence of a cure by
     the Company within 30 days after written notice by you to the Board, a (i)
     a change in title of Vice President, Chief Brand Officer, (ii) a material
     diminution of responsibilities, duties or powers, (iii) a reduction in Base
     Salary, Target Bonus, vacation or other benefits, except that benefits need
     only be substantially equivalent, or (iv) a requirement that you relocate
     your principal place of employment to (or that you travel more than 50 days
     in any calendar year to the Company's principal place of business in) a
     location more than 50 miles from its current location in Cambridge,
     Massachusetts, PROVIDED THAT you must provide the Company with at least
     thirty (30) days advance written notice of your intent to terminate your
     employment hereunder and an opportunity to cure.

     5.  NONCOMPETITION, CONFIDENTIALITY AND INVENTIONS OBLIGATIONS. As a
condition of your employment with the Company and as a condition of this
Agreement, you must execute the Employee Noncompetition, Confidentiality and
Inventions Agreement attached hereto as EXHIBIT A.

     6.  DISCLOSURE TO FUTURE EMPLOYERS. You will provide, and the Company, in
its discretion, may similarly provide, a copy of the covenants contained in the
Employee Noncompetition, Confidentiality and Inventions Agreement to any
business or enterprise which you may, directly or indirectly, own, manage,
operate, finance, join, control or in which you may participate in the
ownership, management, operation, financing, or control, or with which you may
be connected as an officer, director, employee, partner, principal, agent,
representative, consultant or otherwise.

     7.  REPRESENTATIONS. You hereby represent and warrant to the Company that
you understand this Agreement, that you enter into this Agreement voluntarily
and that your employment under this Agreement will not conflict with any legal
duty owed by you to any other party.

     8.  GENERAL.

         (a)    NOTICES. All notices, requests, consents and other
     communications hereunder which are required to be provided, or which the
     sender elects to provide, in writing, will be addressed to the receiving
     party's address set forth above or to such other address as a party may
     designate by notice hereunder, and will be either (i) delivered by hand,
     (ii) sent by overnight courier, or (iii) sent by registered or certified
     mail, return receipt requested, postage prepaid. All notices, requests,
     consents and other communications hereunder will be deemed to have been
     given either (i) if by hand, at the time of the delivery thereof to the
     receiving party at the address of such party set forth above, (ii) if sent
     by overnight courier, on the next business day following the day such
     notice is delivered to the courier service, or (iii) if sent by registered
     or certified mail, on the fifth business day following the day such mailing
     is made.

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Brian Igoe
August 29, 2006
Page 7

         (b)    ENTIRE AGREEMENT. This Agreement, together with any Stock Option
     Agreements executed by you and the Company (either prior to or in
     conjunction with this Agreement), the Employee Noncompetition,
     Confidentiality and Inventions Agreement and the other agreements
     specifically referred to herein, embodies the entire agreement and
     understanding between the parties hereto with respect to the subject matter
     hereof and supersedes all prior oral or written agreements and
     understandings relating to the subject matter hereof. No statement,
     representation, warranty, covenant or agreement of any kind not expressly
     set forth in this Agreement will affect, or be used to interpret, change or
     restrict, the express terms and provisions of this Agreement.

         (c)    MODIFICATIONS AND AMENDMENTS. The terms and provisions of this
     Agreement may be modified or amended only by written agreement executed by
     the parties hereto.

         (d)    WAIVERS AND CONSENTS. The terms and provisions of this Agreement
     may be waived, or consent for the departure therefrom granted, only by
     written document executed by the party entitled to the benefits of such
     terms or provisions. No such waiver or consent will be deemed to be or will
     constitute a waiver or consent with respect to any other terms or
     provisions of this Agreement, whether or not similar. Each such waiver or
     consent will be effective only in the specific instance and for the purpose
     for which it was given, and will not constitute a continuing waiver or
     consent.

         (e)    ASSIGNMENT. The Company may assign its rights and obligations
     hereunder to any person or entity that succeeds to all or substantially all
     of the Company's business or that aspect of the Company's business in which
     you are principally involved or to any Company Affiliate. You may not
     assign your rights and obligations under this Agreement without the prior
     written consent of the Company and any such attempted assignment by you
     without the prior written consent of the Company will be void.

         (f)    GOVERNING LAW. This Agreement and the rights and obligations of
     the parties hereunder will be construed in accordance with and governed by
     the law of Massachusetts, without giving effect to the conflict of law
     principles thereof.

         (g)    JURISDICTION, VENUE AND SERVICE OF PROCESS. Any legal action or
     proceeding with respect to this Agreement will be brought in the courts of
     Massachusetts or of the United States of America for the District of
     Massachusetts. By execution and delivery of this Agreement, each of the
     parties hereto accepts for itself and in respect of its property, generally
     and unconditionally, the exclusive jurisdiction of the aforesaid courts.

         (h)    SEVERABILITY. The parties intend this Agreement to be enforced
     as written. However, if any portion or provision of this Agreement is to
     any extent declared illegal or unenforceable by a duly authorized court
     having jurisdiction, then the remainder of this Agreement, or the
     application of such portion or provision in circumstances other than those
     as to which it is so declared illegal or unenforceable, will not be
     affected thereby, and each

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Brian Igoe
August 29, 2006
Page 8

     portion and provision of this Agreement will be valid and enforceable to
     the fullest extent permitted by law.

         (i)    HEADINGS AND CAPTIONS. The headings and captions of the various
     subdivisions of this Agreement are for convenience of reference only and
     will in no way modify or affect the meaning or construction of any of the
     terms or provisions hereof.

         (j)    ACKNOWLEDGMENTS. You hereby acknowledge and recognize that the
     enforcement of any of the provisions in this Agreement and the
     Noncompetition, Confidentiality and Inventions Agreement may potentially
     interfere with your ability to pursue a proper livelihood. You represent
     that you are knowledgeable about the business of the Company and further
     represent that you are capable of pursuing a career in other industries
     other than the field of noncompetition as set forth in the Noncompetition,
     Confidentiality and Inventions Agreement to earn a proper livelihood. You
     recognize and agree that the enforcement of the Noncompetition,
     Confidentiality and Inventions Agreement is necessary to ensure the
     preservation, protection and continuity of the business, trade secrets and
     goodwill of the Company. You agree that, due to the proprietary nature of
     the Company's business, the restrictions set forth in the Noncompetition,
     Confidentiality and Inventions Agreement are reasonable as to time and
     scope.

         (k)    TAXES. All payments required to be made by the Company to you
     under this Agreement shall be subject to the withholding of such amounts
     for taxes and other payroll deductions as the Company may reasonably
     determine it should withhold pursuant to any applicable law or regulation.
     To the extent applicable, it is intended that this Agreement comply with
     the provisions of Section 409A of the Code, and this Agreement shall be
     construed and applied in a manner consistent with this intent. In the event
     that any severance payments or benefits hereunder are determined by the
     Company to be in the nature of nonqualified deferred compensation payments,
     you and the Company hereby agree to take such actions as may be mutually
     agreed to ensure that such payments or benefits comply with the applicable
     provisions of Section 409A of the Code and the official guidance issued
     thereunder. Notwithstanding the foregoing, the Company does not guarantee
     the tax treatment or tax consequences associated with any payment or
     benefit arising under this Agreement.

         (l)    COUNTERPARTS. This Agreement may be executed in two or more
     counterparts, and by different parties hereto on separate counterparts,
     each of which will be deemed an original, but all of which together will
     constitute one and the same instrument.

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Brian Igoe
August 29, 2006
Page 9

     If the foregoing accurately sets forth our agreement, please so indicate by
signing and returning to us the enclosed copy of this Agreement.

                                                   Very truly yours,

                                                   Metabolix, Inc.

                                                   By: /s/ JAMES J. BARBER
                                                      -------------------------
                                                   Name: James J. Barber
                                                   Title: President and CEO

ACCEPTED AND APPROVED:

/s/ BRIAN IGOE                                     8/29/06
------------------------------                     ------------------
Brian Igoe                                         Date

ATTACHMENT: Exhibit A (Noncompetition, Confidentiality and Inventions Agreement)

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