Document:

First Amendment to Lease

 EXHIBIT 10.2 
 OSMETECH TECHNOLOGY, INC. 
 CLINICAL MICRO SENSORS, INC. 

GENMARK DIAGNOSTICS, INC. 
 LOAN AND SECURITY AGREEMENT 

 This LOAN AND SECURITY AGREEMENT (the “Agreement”) is entered into as of March 12, 2010, by
and between Square 1 Bank (“Bank”) and Osmetech Technology, Inc. (“Osmetech”), Clinical Micro Sensors, Inc. (“CMSI”), and Genmark Diagnostics, Inc. (“Genmark”), (each individually and collectively known as
(“Borrower”). 
 RECITALS 
 Borrower wishes to obtain credit from time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which Bank will advance credit to Borrower, and Borrower
will repay the amounts owing to Bank. 
 AGREEMENT 
 The parties agree as follows: 
  

	 	1.	DEFINITIONS AND CONSTRUCTION. 

 1.1 Definitions. As used in this Agreement, all capitalized terms shall have the definitions set forth on Exhibit A. Any term used in the Code and not defined herein shall have the meaning
given to the term in the Code. 
 1.2 Accounting Terms. Any accounting term not specifically defined on Exhibit A
shall be construed in accordance with GAAP and all calculations shall be made in accordance with GAAP (except for non-compliance with FAS 123R in monthly reporting). The term “financial statements” shall include the accompanying notes and
schedules. 
  

	 	2.	LOAN AND TERMS OF PAYMENT. 

 2.1 Credit Extensions. 
 (a) Promise to Pay. Borrower
promises to pay to Bank, in lawful money of the United States of America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions at
rates in accordance with the terms hereof. 
 (b) Advances Under Formula Revolving Line. 

(i) Amount. Subject to and upon the terms and conditions of this Agreement, Borrower may request Formula Advances in an
aggregate outstanding principal amount not to exceed the lesser of: (A) the Formula Revolving Line; or (B) the Borrowing Base, less any amounts outstanding under the Ancillary Services Sublimit. Amounts borrowed pursuant to this
Section 2.1(b) may be repaid and reborrowed at any time prior to the Formula Revolving Maturity Date, at which time all Formula Advances under this Section 2.1(b) shall be immediately due and payable. Borrower may prepay any
Formula Advances, in whole or in part, from time to time, without penalty or premium. Formula Advances shall be used to support the Borrower’s short-term working capital needs. 

  
 1. 

 (ii) Form of Request. Whenever Borrower desires a Formula Advance, Borrower
will notify Bank by facsimile transmission, telephone or email no later than 5:30 p.m. Eastern time (4:30 p.m. Eastern time for wire transfers), on the Business Day that the Formula Advance is to be made. Each such notification shall be
promptly confirmed by a Loan Advance/Paydown Request Form in substantially the form of Exhibit C. Bank is authorized to make Formula Advances under this Agreement, based upon instructions received from an Authorized Officer, or without
instructions if in Bank’s discretion such Formula Advances are necessary to meet Obligations which have become due and remain unpaid. Bank shall be entitled to rely on any telephonic or email notice given by a person whom Bank reasonably
believes to be an Authorized Officer or a designee thereof, and Borrower shall indemnify and hold Bank harmless for any damages, loss, costs and expenses suffered by Bank as a result of such reliance. Bank will credit the amount of Formula
Advances made under this Section 2.1(b) to Borrower’s deposit account. 
 (iii) Ancillary Services
Sublimit. Subject to the availability under the Formula Revolving Line, at any time and from time to time from the date hereof through the Business Day immediately prior to the Formula Revolving Maturity Date, Borrower may request the
provision of Ancillary Services from Bank. The aggregate limit of the Ancillary Services shall not exceed the Ancillary Services Sublimit, provided that availability under the Formula Revolving Line shall be reduced by the aggregate limits of
(i) any outstanding and undrawn amounts under all Letters of Credit issued hereunder, (ii) corporate credit card services provided to Borrower, (iii) the total amount of any Automated Clearing House processing reserves, (iv) the
applicable Foreign Exchange Reserve Percentage, and (v) any other reserves taken by Bank in connection with other treasury management services requested by Borrower and approved by Bank. In addition, Bank may, in its sole discretion, charge as
Advances any amounts for which Bank becomes liable to third parties in connection with the provision of the Ancillary Services. The terms and conditions (including repayment and fees) of such Ancillary Services shall be subject to the terms and
conditions of the Bank’s standard forms of application and agreement for the applicable Ancillary Services, which Borrower hereby agrees to execute. 
 (iv) Collateralization of Obligations Extending Beyond Maturity. If Borrower has not secured to Bank’s satisfaction its obligations with respect to any Ancillary Services by the Formula
Revolving Maturity Date, then, effective as of such date, the balance in any deposit accounts held by Bank and the certificates of deposit or time deposit accounts issued by Bank in Borrower’s name (and any interest paid thereon or proceeds
thereof, including any amounts payable upon the maturity or liquidation of such certificates or accounts), shall automatically secure such obligations to the extent of the then continuing or outstanding Ancillary Services. Borrower authorizes Bank
to hold such balances in pledge and to decline to honor any drafts thereon or any requests by Borrower or any other Person to pay or otherwise transfer any part of such balances for so long as the applicable Ancillary Services are outstanding or
continue. 
 (c) Equipment Loan. 
 (i) Subject to and upon the terms and conditions of this Agreement, Bank agrees to make one (1) or more Equipment Advances to Borrower.

  
 2. 

 
Borrower may request Equipment Advances at any time from the date hereof through the Availability End Date. The aggregate outstanding amount of Equipment Advances shall not exceed the Equipment
Loan. Each Equipment Advance shall not exceed 100.00% of the invoice amount of equipment and software approved by Bank from time to time (which Borrower shall, in any case, have purchased within 120 days of the date of the corresponding
Equipment Advance), excluding taxes, shipping, warranty charges, freight discounts and installation expense. Equipment Advances shall be used to support Borrower’s Equipment purchasing needs. 

(ii) Interest shall accrue from the date of each Equipment Advance at the rate specified in Section 2.3(a)(ii), and prior to the
Availability End Date, interest only shall be payable monthly beginning on the first date of the month next following the initial Equipment Advance, and continuing on the same day of each month thereafter until the Availability End Date. Any
Equipment Advances that are outstanding on the Availability End Date shall be payable in 24 equal monthly installments of principal, plus all accrued and unpaid interest, beginning on the date one (1) month immediately following the
Availability End Date, and continuing on the same day of each month thereafter through the Equipment Maturity Date, at which time all amounts due in connection with any Equipment Advance made under this Section 2.1(c) and any other amounts due under
this Agreement shall be immediately due and payable. Equipment Advances, once repaid, may not be reborrowed. Borrower may prepay any Equipment Advances, in whole or in part, from time to time, without penalty or premium. 

(iii) When Borrower desires to obtain an Equipment Advance, Borrower shall notify Bank (which notice shall be irrevocable) by
facsimile transmission to be received no later than 3:00 p.m. Eastern time three Business Days before the day on which the Equipment Advance is to be made. Such notice shall be substantially in the form of Exhibit C. The notice shall be signed by a
Responsible Officer or its designee and include a copy of the invoice for any Equipment to be financed. 
 2.2
Overadvances. If the aggregate amount of the outstanding Advances exceeds the lesser of the Formula Revolving Line or the Borrowing Base at any time, Borrower shall immediately pay to Bank, after notice from Bank of such fact, in
cash, the amount of such excess. 
 2.3 Interest Rates, Payments, and Calculations. 

(a) Interest Rates. 
 (i) Formula Advances. Except as set forth in Section 2.3(b), if the Borrowers are in compliance with (A) Section 6.7(a); or (B) Sections 6.7(a) and (b) if any amount is
outstanding pursuant to the Formula Revolving Line, the Formula Advances shall bear interest, on the outstanding daily balance thereof, at a variable annual rate equal to the greater of: (A) 2.75% above the Prime Rate then in effect; or
(B) 6.00%. Alternatively, except as set forth in Section 2.3(b), if the Borrowers are in compliance with Section 6.7b and are not in compliance with Section 6.7(a), then the Formula Advances shall bear interest, on the outstanding daily balance
thereof, at a variable annual rate equal to the greater of: (A) 3.75% above the Prime Rate then in effect; or (B) 7.00%. 

  
 3. 

 (ii) Equipment Advances. Except as set forth in Section 2.3(b), if the
Borrowers are in compliance with (A) Section 6.7(a); or (B) if any amount is outstanding pursuant to the Equipment Loan, Sections 6.7(a) and (c), then the Equipment Advances shall bear interest, on the outstanding daily balance
thereof, at a variable annual rate equal to the greater of: (A) 3.25% above the Prime Rate then in effect; or (B) 6.50%. Alternatively, except as set forth in Section 2.3(b), if the Borrowers are in compliance with Section 6.7(c) and
are not in compliance with Section 6.7(a), then, the Equipment Advances shall bear interest, on the outstanding daily balance thereof, at a variable annual rate equal to the greater of: (A) 4.25% above the Prime Rate then in effect; or
(B) 7.50%. 
 (b) Late Fee; Default Rate. If any payment is not made within 15 days after the date such
payment is due, Borrower shall pay Bank a late fee equal to the lesser of (i) 5% of the amount of such unpaid amount or (ii) the maximum amount permitted to be charged under applicable law. All Obligations shall bear interest, from and
after the occurrence and during the continuance of an Event of Default, at a rate equal to 5 percentage points above the interest rate applicable immediately prior to the occurrence of the Event of Default. 

(c) Payments. Interest under the Formula Revolving Line shall be due and payable on the first calendar day of each month
during the term hereof. Bank shall, at its option, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts or against the Formula Revolving Line, in which case those amounts shall thereafter
accrue interest at the rate then applicable hereunder. Any interest not paid when due shall be compounded by becoming a part of the Obligations, and such interest shall thereafter accrue interest at the rate then applicable hereunder. All payments
shall be free and clear of any taxes, withholdings, duties, impositions or other charges, to the end that Bank will receive the entire amount of any Obligations payable hereunder, regardless of source of payment. 

(d) Computation. In the event the Prime Rate is changed from time to time hereafter, the applicable rate of interest
hereunder shall be increased or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest chargeable under the Loan Documents shall be computed on the basis of a 360 day year for
the actual number of days elapsed. 
 2.4 Crediting Payments. Unless an Event of Default has occurred and is
continuing, Bank shall credit a wire transfer of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies, except that to the extent Borrower uses the Equipment Advances to purchase Collateral,
Borrower’s repayment of the Equipment Advances shall apply on a “first-in-first-out” basis so that the portion of the Equipment Advances used to purchase a particular item of Collateral shall be paid in the chronological order the
Borrower purchased the Collateral. After the occurrence and during the continuance of an Event of Default, Bank shall have the right, in its sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment Bank may
receive to conditionally reduce Obligations, but such applications of funds shall not be considered a payment on account unless such payment 

  
 4. 

 
is of immediately available federal funds or unless and until such check or other item of payment is honored when presented for payment. Bank shall remit any amounts remaining after such
application of funds to such deposit account as Borrower specifies. Notwithstanding anything to the contrary contained herein, any wire transfer or payment received by Bank after 5:30 p.m. Eastern time shall be deemed to have been received by Bank
as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under the Loan Documents would otherwise be due (except by reason of acceleration) on a date that is not a Business Day, such payment shall instead
be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be payable for the period of such extension. 
 2.5 Fees. Borrower shall pay to Bank the following: 
 (a)
Facility Fee. On or before the Closing Date, a fee equal to $20,000, which shall be nonrefundable; 
 (b) Bank
Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date, with legal expenses to equal no more than $15,000, provided that there are no more than 2 turns of the Loan Documents drafts and that UCC and corporate
good standing searches will not be subject to the aforementioned $15,000 limit. After the Closing Date, all Bank Expenses, as and when they become due. 
 (c) Unused Fee. Paid quarterly in arrears, a fee in the amount of 0.25% of the following calculation: (i) the maximum aggregate amount of the Formula Advances and Equipment Advances
available to Borrower; less (ii) the amount of the Formula Advances and Equipment Advances outstanding; provided however, that no fee shall be due based upon the Equipment Advances after the Availability End Date. 

2.6 Term. This Agreement shall become effective on the Closing Date and, subject to Section 12.7, shall
continue in full force and effect for so long as any Obligations (other than any inchoate indemnification obligations) remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding the foregoing, Bank
shall have the right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice upon the occurrence and during the continuance of an Event of Default. Notwithstanding the foregoing, Borrowers shall have
the right to terminate this Agreement by delivering written notice to Bank, subject to the condition that there are no Obligations (other than any inchoate indemnification obligations) outstanding under this Agreement at the time of such
termination. 
  

	 	3.	CONDITIONS OF LOANS. 

 3.1 Conditions Precedent to Closing. The agreement of Bank to enter into this Agreement on the Closing Date is subject to the condition precedent that Bank shall have received, in form
and substance satisfactory to Bank, each the following items and completed each of the following requirements: 
 (a)
this Agreement; 

  
 5. 

 (b) an officer’s certificate of Borrower with respect to incumbency and
resolutions authorizing the execution and delivery of this Agreement for each Borrower; 
 (c) a financing statement
(Form UCC-1) for each Borrower; 
 (d) an intellectual property security agreement for each Borrower; 

(e) payment of the fees and Bank Expenses then due specified in Section 2.5, which may be debited from any of Borrower’s
deposit accounts with Bank; 
 (f) current SOS Reports for each Borrower indicating that except for Permitted Liens,
there are no other security interests or Liens of record in the Collateral; 
 (g) prior to the making of any Formula
Advances, but not required before the making of any Equipment Advances, an audit of the Collateral, the results of which shall be satisfactory to Bank; 
 (h) current financial statements for each Borrower, including audited statements (or such other level required by the Investment Agreement) for Borrower’s most recently ended fiscal year,
together with an unqualified opinion (or an opinion qualified only for going concern so long as Borrower’s investors provide additional equity as needed), company prepared consolidated and consolidating balance sheets and income statements for
the most recently ended month in accordance with Section 6.2, and such other updated financial information as Bank may reasonably request; 
 (i) current Compliance Certificate in accordance with Section 6.2; 

(j) a Borrower Information Certificate for each Borrower; 

(k) Borrower shall have opened and funded not less than $50,000 in deposit accounts held with Bank; and 

(l) such other documents or certificates, and completion of such other matters, as Bank may reasonably request. 

3.2 Conditions Precedent to all Credit Extensions. The obligation of Bank to make each Credit Extension, including the
initial Credit Extension, is contingent upon the Borrower’s compliance with Section 3.1 above, and is further subject to the following conditions: 
 (a) timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in Section 2.1; 
 (b) Borrower shall have transferred substantially all of its Cash assets into deposit accounts held with Bank and otherwise be in compliance with Section 6.6 hereof; and 

  
 6. 

 (c) the representations and warranties contained in Section 5 shall be true and
correct in all material respects on and as of the date of such Loan Advance/Paydown Request Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have occurred and be
continuing, or would exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as of such date).
The making of each Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 

 

	 	4.	CREATION OF SECURITY INTEREST. 

 4.1 Grant of Security Interest. Borrower grants and pledges to Bank a continuing security interest in their respective interests in the Collateral to secure prompt repayment of any
and all Obligations and to secure prompt performance by Borrower of each of its covenants and duties under the Loan Documents. Except for Permitted Liens or as disclosed in the Schedule, such security interest constitutes a valid, first priority
security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in later-acquired Collateral assuming that Bank perfects and maintains the perfection of Bank’s security interest (to the
extent within Bank’s control) and does not subordinate its Lien on the Collateral. Borrower also hereby agrees not to sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its Intellectual Property
Collateral. Notwithstanding any termination of this Agreement or of any filings undertaken related to Bank’s rights under the Code, Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations (other than inchoate
indemnification obligations) are outstanding. 
 4.2 Perfection of Security Interest. Borrower authorizes
Bank to file at any time financing statements, continuation statements, and amendments thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged hereunder, and
(ii) contain any other information required by the Code for the sufficiency of filing office acceptance of any financing statement, continuation statement, or amendment, including whether Borrower is an organization, the type of organization
and any organizational identification number issued to Borrower, if applicable. Borrower shall have possession of the Collateral, except where expressly otherwise provided in this Agreement or where Bank reasonably chooses to perfect its security
interest by possession in addition to the filing of a financing statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) subject to Section 7.10 below,
obtain an acknowledgment, in form and substance reasonably satisfactory to Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, and (ii) obtain “control” of any Collateral consisting of investment
property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such items and the term “control” are defined in Revised Article 9 of the Code) by causing the securities intermediary or depositary institution or issuing
bank to execute a control agreement in form and substance reasonably satisfactory to Bank. Borrower will not create any chattel paper without placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security interest in
the chattel paper. Borrower from time to time may deposit with Bank specific cash collateral to secure specific Obligations (other than inchoate indemnification obligations); Borrower authorizes Bank to hold such specific balances in pledge

  
 7. 

 
and to decline to honor any drafts thereon or any request by Borrower or any other Person to pay or otherwise transfer any part of such balances for so long as the specific Obligations are
outstanding. Borrower shall take such other actions as Bank reasonably requests to perfect its security interests granted under this Agreement. 
  

	 	5.	REPRESENTATIONS AND WARRANTIES. 

 Borrower represents and warrants as follows: 
 5.1 Due Organization and
Qualification. Borrower and each Subsidiary, if applicable, is a corporation duly existing under the laws of the state in which it is organized and qualified and licensed to do business in any state in which the conduct of its
business or its ownership of property requires that it be so qualified, except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect. 
 5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the Loan Documents are within Borrower’s powers, have been duly authorized, and are not in
conflict with nor constitute a breach of any provision contained in Borrower’s Articles of Incorporation or Bylaws, nor will they constitute an event of default under any material agreement by which Borrower is bound. Borrower is not in default
under any agreement by which it is bound, except to the extent such default would not reasonably be expected to cause a Material Adverse Effect. 
 5.3 Collateral. Borrower has rights in or the power to transfer the Collateral, and its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on
transfer or pledge except for Permitted Liens. Other than movable items of personal property such as laptop computers, all Collateral having an aggregate book value not in excess of $100,000, is located solely in the Collateral States, unless it is
in transit to Borrowers or one of their customers. The Eligible Accounts are bona fide existing obligations. The property or services giving rise to such Eligible Accounts has been delivered or rendered to the account debtor or its agent for
immediate shipment to and unconditional acceptance by the account debtor. Borrower has not received notice of an actual or imminent Insolvency Proceeding of any account debtor whose accounts are included in any Borrowing Base Certificate as an
Eligible Account. All Inventory is in all material respects of good and merchantable quality, free from all material defects, except for Inventory for which adequate reserves have been made. Except as set forth in the Schedule, none of the
Borrower’s Cash is maintained or invested with a Person other than Bank or Bank’s Affiliates. 
 5.4 Intellectual
Property Collateral. Borrower is the sole owner of the Intellectual Property Collateral, except for licenses granted by Borrower to its customers in the ordinary course of business. To the best of Borrower’s knowledge, each of
the Copyrights, Trademarks and Patents is valid and enforceable, and no part of the Intellectual Property Collateral has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower that any part of the
Intellectual Property Collateral violates the rights of any third party except to the extent such claim would not reasonably be expected to cause a Material Adverse Effect. 

  
 8. 

 5.5 Name; Location of Chief Executive Office. Except as disclosed in
the Schedule, Borrower has not done business under any name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement; provided, however, that CMSI conducts business
under the DBA of “Osmetech Molecular Diagnostics”. The chief executive office of Osmetech is located at the address indicated in Section 10 hereof. 
 5.6 Litigation. Except as set forth in the Schedule, there are no actions or proceedings pending by or against Borrower or any Subsidiary, as applicable, before any court or
administrative agency in which a likely adverse decision would reasonably be expected to have a Material Adverse Effect. 

5.7 No Material Adverse Change in Financial Statements. All consolidated and consolidating financial statements
related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly present in all material respects Borrower’s consolidated and consolidating financial condition as of the date thereof and Borrower’s consolidated and
consolidating results of operations for the period then ended. There has not been a material adverse change in the consolidated or in the consolidating financial condition of Borrower since the date of the most recent of such financial statements
submitted to Bank. 
 5.8 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade
debts) as they mature; the Borrower believes in good faith that the fair saleable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably
small capital after the transactions contemplated by this Agreement. 
 5.9 Compliance with Laws and
Regulations. Borrower and each Subsidiary have met the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with
ERISA that is reasonably likely to result in Borrower’s incurring any liability that could have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled” by an “investment
company” within the meaning of the Investment Company Act of 1940. Borrower is not engaged principally, or as one of its important activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within
the meaning of Regulations T and U of the Board of Governors of the Federal Reserve System). Borrower has not violated any statutes, laws, ordinances or rules applicable to it, the violation of which would reasonably be expected to have a Material
Adverse Effect. Borrower and each Subsidiary have filed or caused to be filed all tax returns required to be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected therein except those being contested in good
faith with adequate reserves under GAAP or where the failure to file such returns or pay such taxes would not reasonably be expected to have a Material Adverse Effect. 
 5.10 Subsidiaries. Borrower does not own any stock, partnership interest or other equity securities of any Person, except for Permitted Investments. 

5.11 Government Consents. Borrower and each Subsidiary have obtained all consents, approvals and authorizations of,
made all declarations or filings with, and given all 

  
 9. 

 
notices to, all governmental authorities that are necessary for the continued operation of Borrower’s business as currently conducted, except where the failure to do so would not reasonably
be expected to cause a Material Adverse Effect. 
 5.12 Inbound Licenses. Except as disclosed on the
Schedule, Borrower is not a party to, nor is bound by, any material license or other agreement material to the conduct of Borrower’s business that prohibits or otherwise restricts Borrower from granting a security interest in Borrower’s
interest in such license or agreement or any other property material to the conduct of Borrower’s business, other than this Agreement or the other Loan Documents. 
 5.13 Full Disclosure. No representation, warranty or other statement made by Borrower in any certificate or written statement furnished to Bank taken together with all such
certificates and written statements furnished to Bank contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements contained in such certificates or statements not misleading in light
of the circumstances in which they were made, it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not to be viewed as facts and that actual results during the
period or periods covered by any such projections and forecasts may differ from the projected or forecasted results. 
  

	 	6.	AFFIRMATIVE COVENANTS. 

 Borrower covenants that, until payment in full of all outstanding Obligations (other than inchoate indemnification obligations), and for so long as Bank may have any commitment to make a Credit Extension
hereunder, Borrower shall do all of the following: 
 6.1 Good Standing and Government Compliance. Borrower
shall maintain its and each of its Subsidiaries’, as applicable, corporate existence and good standing in the respective states of formation, shall maintain qualification and good standing in each other jurisdiction in which the failure to so
qualify would reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if applicable. Borrower
shall meet, and shall cause each Subsidiary, if applicable, to meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. Borrower shall comply, and shall cause each Subsidiary, if applicable, to
comply, with all statutes, laws, ordinances and government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries, if applicable, to maintain, in force all licenses, approvals and agreements, the
loss of which or failure to comply with which would reasonably be expected to have a Material Adverse Effect. 
 6.2
Financial Statements, Reports, Certificates. For purposes of this Section 6.2, “Borrower” shall mean either Osmetech or Genmark, based upon which entity is the parent company of the other company (i.e. the company
that owns controlling interesting of the other company.) Borrower shall deliver to Bank: (i) as soon as available, but in any event within 30 days after the end of each calendar month, a company prepared consolidated and consolidating balance
sheet and income statement covering Borrower’s operations during such period, in a form reasonably acceptable to Bank and certified by a Responsible Officer; (ii) as 

  
 10.

 
soon as available, but in any event within 180 days after the end of Borrower’s fiscal year for each fiscal year from and after the fiscal year beginning January 1, 2010, audited (or
such other level as is required by the Investment Agreement) consolidated and consolidating financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with an opinion which is either unqualified, qualified only
for going concern so long as Borrower’s investors provide additional equity as needed or otherwise consented to in writing by Bank on such financial statements of an independent certified public accounting firm reasonably acceptable to Bank;
(iii) annual budget approved by Borrower’s Board of Directors as soon as available but not later than November 30th of the prior fiscal year; (iv) if applicable, copies of all statements, reports and notices sent or made
available generally by Borrower to its security holders or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed with the Securities and Exchange Commission; (v) promptly upon receipt of notice thereof, a report of
any legal actions pending or threatened against Borrower or any Subsidiary that could reasonably be expected to result in damages or costs to Borrower or any Subsidiary of $250,000 or more; (vi) promptly upon receipt, each management letter
prepared by Borrower’s independent certified public accounting firm regarding Borrower’s management control systems, (vii) such budgets, sales projections, operating plans or other financial information generally prepared by Borrower
in the ordinary course of business as Bank may reasonably request from time to time; and (viii) within 30 days of the last day of each fiscal quarter, a report signed by Borrower, in form reasonably acceptable to Bank, listing any applications
or registrations that Borrower has made or filed in respect of any Patents, Copyrights or Trademarks and the status of any outstanding applications or registrations, as well as any material change in Borrower’s Intellectual Property Collateral,
including but not limited to any subsequent ownership right of Borrower in or to any Trademark, Patent or Copyright not specified in Exhibits A, B, and C of any Intellectual Property Security Agreement delivered to Bank by Borrower in connection
with this Agreement. 
 (a) Within 30 days after the last day of each month, Borrower shall deliver to Bank a Borrowing
Base Certificate signed by a Responsible Officer in substantially the form of Exhibit D hereto, together with aged listings by invoice date of accounts receivable and accounts payable. 

(b) Within 30 days after the last day of each month, Borrower shall deliver to Bank with the monthly financial statements a
Compliance Certificate certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit E hereto. 
 (c) As soon as possible and in any event within 3 Business Days after becoming aware of the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible Officer
setting forth details of the Event of Default, and the action which Borrower has taken or proposes to take with respect thereto. 
 (d) Bank (through any of its officers, employees, or agents) shall have the right, upon reasonable prior notice, from time to time during Borrower’s usual business hours but no more than twice
a year (unless an Event of Default has occurred and is continuing), to inspect Borrower’s Books and to make copies thereof and to check, test, inspect, audit and appraise the Collateral at Borrower’s expense, in order to verify
Borrower’s financial condition 

  
 11.

 
or the amount, condition of, or any other matter relating to, the Collateral. Borrower agrees that ff Borrowers’ Accounts comprise more than a majority of Borrowers’ Liquidity, then
Bank may conduct a Collateral audit under customary and reasonable terms as provided herein. 
 Borrower may deliver to Bank on
an electronic basis any certificates, reports or information required pursuant to this Section 6.2, and Bank shall be entitled to rely on the information contained in the electronic files, provided that Bank in good faith believes that the
files were delivered by a Responsible Officer. Borrower shall include a submission date on any certificates and reports to be delivered electronically. 
 6.3 Inventory and Equipment; Returns. Borrower shall keep all Inventory and Equipment in good and merchantable condition, free from all material defects except for Inventory and
Equipment (i) sold in the ordinary course of business, and (ii) for which adequate reserves have been made, in all cases in the United States and such other locations as to which Borrower gives prior written notice. Returns and allowances,
if any, as between Borrower and its account debtors shall be on the same basis and in accordance with the usual customary practices of Borrower, as they exist on the Closing Date. Borrower shall promptly notify Bank of all returns and recoveries and
of all disputes and claims involving inventory having a book value of more than $250,000. 
 6.4 Taxes.
Borrower shall make, and cause each Subsidiary, as applicable, to make, due and timely payment or deposit of all material federal, state, and local taxes, assessments, or contributions required of it by law, including, but not limited to, those laws
concerning income taxes, F.I.C.A., F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof reasonably satisfactory to Bank indicating that Borrower or a Subsidiary, as applicable, has made such payments or deposits and
any appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a Subsidiary, as applicable, need not make any payment if the amount or validity of such payment is contested in good faith by appropriate
proceedings and is reserved against (to the extent required by GAAP) by Borrower or such Subsidiary. 
 6.5
Insurance. Borrower, at its expense, shall (i) keep the Collateral insured against loss or damage, and (ii) maintain liability and other insurance, in each case in as ordinarily insured against by other owners in
businesses similar to Borrower’s. All such policies of insurance shall be in such form, with such companies, and in such amounts as reasonably satisfactory to Bank. All policies of property insurance shall contain a lender’s loss payable
endorsement, in a form reasonably satisfactory to Bank, showing Bank as an additional loss payee, and all liability insurance policies shall show Bank as an additional insured and specify that the insurer must give at least 20 days notice to Bank
before canceling its policy for any reason. Within 30 days of the Closing Date, Borrower shall cause to be furnished to Bank a copy of its policies or certificate of insurance including any endorsements covering Bank or showing Bank as an additional
insured. Upon Bank’s request, Borrower shall deliver to Bank certified copies of the policies of insurance and evidence of all premium payments. Proceeds payable under any casualty policy will, at Borrower’s option, be payable to Borrower
to replace the property subject to the claim, provided that any such replacement property shall be deemed Collateral in which Bank has been granted a first priority security interest, provided that if an Event of Default has occurred and is
continuing, all proceeds payable under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the Obligations. 

  
 12.

 6.6 “Primary Depository”. Subject to the provisions of
Section 3.1(k) and 3.2(b), prior to December 31, 2010, Borrower shall maintain all its depository and operating accounts with Bank and its primary investment accounts with Bank or Bank’s affiliates, until such time as any
Borrower’s equity is publicly traded in an established securities market, in which case, Borrower may allocate any depository and investment accounts between Bank and other third party accounts. 

6.7 Financial Covenants. Borrower shall at all times maintain the financial ratios and covenants, as follows: 

(a) Liquidity Ratio. A Liquidity Ratio of at least 1.50 to 1.00; OR 

(b) Current Ratio. At all times when any amount is outstanding pursuant to the Formula Revolving Line, a minimum
Current Ratio of at least 1.50 to 1.00; AND 
 (c) Cash Burn. At all times when any amount is outstanding
pursuant to the Equipment Loan, measured on a trailing three-months basis, a Cash Burn of not more than the amounts shown in the table immediately below for the corresponding monthly reporting period. Amounts required by this covenant for 2011 shall
be reasonably set by Bank (and incorporated herein by an amendment hereto, which Borrower hereby agrees to promptly execute) based upon Borrowers’ 2011 budget, which shall be approved by Borrowers’ boards of directors, as applicable, and
delivered to Bank no later than November 30, 2010. 
  

					
	 Mar-10
	  	$	6,152,021	  
	 Apr-10
	  	$	5,472,801	  
	 May-10
	  	$	4,786,896	  
	 Jun-10
	  	$	4,824,807	  
	 Jul-10
	  	$	5,052,808	  
	 Aug-10
	  	$	5,972,531	  
	 Sep-10
	  	$	5,499,620	  
	 Oct-10
	  	$	4,796,006	  
	 Nov-10
	  	$	3,548,868	  
	 Dec-10
	  	$	3,128,374	  

 6.8 Registration of Intellectual Property Rights. 

(a) Borrower shall promptly give Bank written notice of any applications or registrations of intellectual property rights filed
with the United States Patent and Trademark Office, including the date of such filing and the registration or application numbers, if any. 

  
 13.

 (b) Borrower shall (i) give Bank not less than 30 days prior written notice of
the filing of any applications or registrations with the United States Copyright Office, including the title of such intellectual property rights to be registered, as such title will appear on such applications or registrations, and the date such
applications or registrations will be filed; (ii) prior to the filing of any such applications or registrations, execute such documents as Bank may reasonably request for Bank to maintain its perfection in such intellectual property rights to
be registered by Borrower; (iii) upon the request of Bank, either deliver to Bank or file such documents simultaneously with the filing of any such applications or registrations; (iv) upon filing any such applications or registrations,
promptly provide Bank with a copy of such applications or registrations together with any exhibits, evidence of the filing of any documents requested by Bank to be filed for Bank to maintain the perfection and priority of its security interest in
such intellectual property rights, and the date of such filing. 
 (c) Borrower shall execute and deliver such
additional instruments and documents from time to time as Bank shall reasonably request to perfect and maintain the perfection and priority of Bank’s security interest in the Intellectual Property Collateral. 

(d) Borrower shall (i) use commercially reasonable efforts to protect, defend and maintain the validity and enforceability
of the trade secrets, Trademarks, Patents and Copyrights, (ii) use commercially reasonable efforts to detect infringements of the Trademarks, Patents and Copyrights and promptly advise Bank in writing of material infringements detected and
(iii) not allow any material Trademarks, Patents or Copyrights to be abandoned, forfeited or dedicated to the public without the written consent of Bank, which shall not be unreasonably withheld. 

(e) Bank shall have the right, but not the obligation, to take, at Borrower’s sole expense, any actions that Borrower is
required under this Section 6.8 to take but which Borrower fails to take, after 15 days’ notice to Borrower. Borrower shall reimburse and indemnify Bank for all reasonable costs and reasonable expenses incurred in the reasonable exercise
of its rights under this Section 6.8. 
 6.9 Osmetech, Inc. No later than 120 days after the Closing Date, unless a
materially adverse tax event would result therefrom, Borrower shall dissolve Osmetech, Inc. and transfer all assets from such entity to Borrower. 
 6.10 Further Assurances. At any time and from time to time Borrower shall execute and deliver such further instruments and take such further action as may reasonably be requested by Bank to effect
the purposes of this Agreement. 
  

	 	7.	NEGATIVE COVENANTS. 

Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations (other than
inchoate indemnification obligations) are paid in full or for so long as Bank may have any commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior written consent, which shall not be unreasonably
withheld: 
 7.1 Dispositions. Other than Permitted Transfers, (a) convey, sell, lease, license, transfer or
otherwise dispose of (collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, or (b) move cash balances on deposit with Bank to accounts opened at another financial
institution. 

  
 14.

 7.2 Change in Name, Location, Executive Office, or Executive Management; Change in
Business; Change in Fiscal Year; Change in Control. Change its name or the state of Borrower’s formation or relocate its chief executive office without 21 days prior written notification to Bank; replace or suffer the departure of its chief
executive officer or chief financial officer without delivering written notification to Bank within 10 days; fail to appoint an interim replacement or fill a vacancy in the position of chief executive officer or chief financial officer for more than
30 consecutive days; take action to liquidate, wind up, or otherwise cease to conduct business in the ordinary course; engage in any business, or permit any of its Subsidiaries to engage in any business, other than or reasonably related or
incidental to the businesses currently engaged in by Borrower; change its fiscal year end; have a Change in Control. 
 7.3
Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with or into any other business organization (other than mergers or consolidations of a Subsidiary into another Subsidiary or into
Borrower), or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person except where (a) each of the following conditions is applicable: (i) the consideration
paid in connection with such transactions (including assumption of liabilities) does not in the aggregate exceed $250,000 during any fiscal year , (ii) no Event of Default has occurred, is continuing or would exist after giving effect to such
transactions, (iii) such transactions do not result in a Change in Control, and (iv) Borrower is the surviving entity; or (b) the Obligations are repaid in full concurrently with the closing of any merger or consolidation of Borrower
in which Borrower is not the surviving entity (s “Sale”), or there are no Obligations outstanding upon the closing of a Sale, in either circumstance contingent upon Borrowers’ delivery to Bank of a written notice that Borrowers are
terminating this Agreement and that no additional Credit Extensions shall be requested hereunder; provided, however, that Borrower shall not, without Bank’s prior written consent, enter into any binding contractual arrangement with any
Person to attempt to facilitate a merger or acquisition of Borrower; provided however, Borrower may enter into any such agreement without Bank’s prior written consent so long as (i) no Event of Default exists when such agreement is entered
into by Borrower, (ii) such agreement does not give such Person the right to claim any fee, payment or damages from any parties, other than from Borrower or Borrower’s investors, in connection with a sale of Borrower’s stock or assets
pursuant to or resulting from an assignment for the benefit of creditors, an asset turnover to Borrower’s creditors (including, without limitation, Bank), foreclosure, bankruptcy or similar liquidation, and (iii) Borrower notifies Bank in
advance of entering into such an agreement (provided, the failure to give such notification shall not be deemed a material breach of this Agreement). 
 7.4 Indebtedness. Create, incur, assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any
Indebtedness or take any actions which impose on Borrower an obligation to prepay any Indebtedness, except Indebtedness to Bank. 

  
 15.

 7.5 Encumbrances. Create, incur, assume or allow any Lien with respect to its
property, or assign or otherwise convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens, or covenant to any other Person (other than (i) the licensors of
in-licensed property with respect to such property or (ii) the lessors of specific equipment or lenders financing specific equipment with respect to such leased or financed equipment) that Borrower in the future will refrain from creating,
incurring, assuming or allowing any Lien with respect to any of Borrower’s property. 
 7.6 Distributions. Pay any
dividends or make any other distribution or payment on account of or in redemption, retirement or purchase of any capital stock, except that Borrower may (i) repurchase the stock of former employees or consultants pursuant to stock repurchase
agreements as long as an Event of Default does not exist prior to such repurchase or would not exist after giving effect to such repurchase, and (ii) repurchase the stock of former employees or consultants pursuant to stock repurchase
agreements by the cancellation of indebtedness owed by such former employees or consultants to Borrower regardless of whether an Event of Default exists. 
 7.7 Investments. Directly or indirectly acquire or own, or make any Investment in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted Investments, or maintain or
invest any of its Investment Property, as defined in the Code, with a Person other than Bank or Bank’s Affiliates or permit any Subsidiary to do so unless such Person has entered into a control agreement with Bank, in form and substance
reasonably satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying dividends or otherwise distributing property to Borrower. 

7.8 Transactions with Affiliates. Directly or indirectly enter into or permit to exist any material transaction with any Affiliate
of Borrower except for: (a) transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are no less favorable to Borrower than would be obtained in an arm’s length transaction with a
non-affiliated Person; (b) reasonable and customary fees paid to members of the board of directors (or similar governing body) of such Borrower; (c) compensation arrangements for officers and other employees of or consultants to such
Borrower and any Subsidiaries entered into in the ordinary course of business upon fair and reasonable terms that are no less favorable to such Borrower than would be obtained in an arm’s length transaction with a non-affiliated person;
(d) transactions described in the Schedule; and (e) any transactions exclusively by and among any Borrowers otherwise permitted pursuant to this Agreement. 
 7.9 Subordinated Debt. Make any payment in respect of any Subordinated Debt, or permit any of its Subsidiaries to make any such payment, except in compliance with the terms of such Subordinated
Debt, or amend any provision affecting Bank’s rights contained in any documentation relating to the Subordinated Debt without Bank’s prior written consent. 
 7.10 Inventory and Equipment. Store the Inventory or the Equipment of a book value in excess of $250,000 with a bailee, warehouseman, collocation facility or similar third party unless the third
party has been notified of Bank’s security interest and Bank (a) has received an acknowledgment from the third party that it is holding or will hold the Inventory or Equipment for Bank’s benefit or (b) is in possession of the
warehouse receipt, where negotiable, 

  
 16.

 
covering such Inventory or Equipment. Except for Inventory sold in the ordinary course of business and for movable items of personal property having an aggregate book value not in excess of
$250,000, and except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only at the location set forth in Section 10 and such other locations of which Borrower gives Bank prior written
notice and as to which Bank is able to take such actions as may be necessary to perfect its security interest or to obtain a bailee’s acknowledgment of Bank’s rights in the Collateral. 

7.11 No Investment Company; Margin Regulation. Become or be controlled by an “investment company,” within the meaning of
the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business of extending credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit
Extension for such purpose. 
  

	 	8.	EVENTS OF DEFAULT. 

 Any
one or more of the following events shall constitute an Event of Default by Borrower under this Agreement: 
 8.1 Payment
Default. If Borrower fails to pay any of the Obligations when due; 
 8.2 Covenant Default. 

(a) If Borrower fails to perform any obligation under Sections 6.2 (financial reporting), 6.4 (taxes), 6.5 (insurance), 6.6
(primary accounts) or 6.7 (financial covenants), or violates any of the covenants contained in Article 7 of this Agreement; or 

(b) If Borrower fails or neglects to perform or observe any other material term, provision, condition, covenant contained in this
Agreement, in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under such other term, provision, condition or covenant that can be cured, has failed to cure such default within 15
days after Borrower receives notice thereof or any officer of Borrower becomes aware thereof; provided, however, that if the default cannot by its nature be cured within the 15 day period or cannot after diligent attempts by Borrower be cured within
such 15 day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional reasonable period (which shall not in any case exceed 30 days) to attempt to cure such default, and within such reasonable
time period the failure to have cured such default shall not be deemed an Event of Default but no Credit Extensions will be made. 
 8.3 Material Adverse Change. If there occurs any circumstance or any circumstances which would reasonably be expected to have a Material Adverse Effect; 

8.4 Attachment. If any material portion of Borrower’s assets is attached, seized, subjected to a writ or distress warrant, or
is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged or rescinded within 10 days, or if Borrower
is enjoined, restrained, or in any way prevented by court order from continuing to 

  
 17.

 
conduct all or any material part of its business affairs, and such court order has not been vacated within 10 days, or if a judgment or other claim becomes a lien or encumbrance upon any material
portion of Borrower’s assets, and such lien or encumbrance has not been released within 10 days, or if a notice of lien, levy, or assessment is filed of record with respect to any material portion of Borrower’s assets by the United
States Government, or any department, agency, or instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten days after Borrower receives notice thereof, provided that none of the
foregoing shall constitute an Event of Default where such action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made during such cure period); 

8.5 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by Borrower, or if an Insolvency
Proceeding is commenced against Borrower and is not dismissed or stayed within 45 days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 

8.6 Other Agreements. If there is a default or other failure to perform in any agreement to which Borrower is a party with a third
party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $350,000 or that would reasonably be expected to have a Material Adverse Effect;
provided, however, that the Event of Default under this Section caused by the occurrence of a default under another agreement described in this Section shall be automatically cured for purposes of this Agreement upon the cure or waiver of the
default under such other agreement, and delivery of written notice of the same to Bank from the party declaring such default; 

8.7 Judgments. If a final, uninsured judgment or judgments for the payment of money in an amount, individually or in the
aggregate, of at least $350,000 shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of 10 days (provided that no Credit Extensions will be made prior to the satisfaction or stay of the judgment); or 

8.8 Misrepresentations. If any material misrepresentation or material misstatement exists now or hereafter in any warranty or
representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this Agreement or any other Loan Document. 

 

	 	9.	BANK’S RIGHTS AND REMEDIES. 

 9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may, at its election, without notice of its election and without demand, do any one or more of
the following, all of which are authorized by Borrower: 
 (a) Declare all Obligations, whether evidenced by this
Agreement, by any of the other Loan Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.5 (insolvency), all Obligations shall become immediately due and payable
without any action by Bank); 

  
 18.

 (b) Demand that Borrower (i) deposit cash with Bank in an amount equal to the
amount of any Letters of Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the
remaining term of the Letters of Credit, and Borrower shall promptly deposit and pay such amounts; 
 (c) Cease
advancing money or extending credit to or for the benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 
 (d) Settle or adjust disputes and claims directly with account debtors for amounts, upon terms and in whatever order that Bank reasonably considers advisable; 

(e) Make such payments and do such acts as Bank considers necessary or reasonable to protect its security interest in the
Collateral. Borrower agrees to assemble the Collateral if Bank so requires, and to make the Collateral available to Bank as Bank may designate. Borrower authorizes Bank to enter the premises where the Collateral is located, to take and maintain
possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s determination appears to be prior or superior to its security interest and to pay all expenses
incurred in connection therewith. With respect to any of Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such premises and to occupy the same, without charge, in order to exercise any of Bank’s
rights or remedies provided herein, at law, in equity, or otherwise; 
 (f) Set off and apply to the Obligations any and
all (i) balances and deposits of Borrower held by Bank, and (ii) indebtedness at any time owing to or for the credit or the account of Borrower held by Bank; 
 (g) Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell (in the manner provided for herein) the Collateral. Bank is hereby granted a license or
other right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s labels, patents, copyrights, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising
matter, or any property of a similar nature, as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with Bank’s exercise of its rights under this Section
9.1, Borrower’s rights under all licenses and all franchise agreements shall inure to Bank’s benefit; 

(h) Sell the Collateral at either a public or private sale, or both, by way of one or more contracts or transactions, for cash or
on terms, in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the Obligations in whatever manner or order Bank deems appropriate. Bank may sell the
Collateral without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties of title or the like. This procedure will not be considered adversely to affect the commercial reasonableness of any sale of the Collateral.
If Bank sells any of the Collateral upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the indebtedness of the purchaser. If the purchaser fails to pay for the Collateral, Bank
may resell the Collateral and Borrower shall be credited with the proceeds of the sale; 

  
 19.

 (i) Bank may credit bid and purchase at any public sale; 

(j) Apply for the appointment of a receiver, trustee, liquidator or conservator of the Collateral, without notice and without
regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of the Obligations; and 

(k) Any deficiency that exists after disposition of the Collateral as provided above will be paid immediately by Borrower.

 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the Collateral and
compliance will not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 
 If Bank
delivers any notice of exclusive control, any entitlement order or other directions or instructions pursuant to any control agreement or similar agreement providing for control of any Collateral to any Person, then upon the cure of any Event of
Default (provided that the determination of whether an Event of Default has been cured shall be made by Bank in its sole discretion) during which the Bank has delivered a notice of exclusive control, entitlement order or other direction or
instructions pursuant to a control agreement Bank shall rescind such notice, order, direction or instruction. 
 9.2 Power of
Attorney. Effective only upon the occurrence and during the continuance of an Event of Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful attorney to:
(a) send requests for verification of Accounts or notify account debtors of Bank’s security interest in the Accounts; (b) endorse Borrower’s name on any checks or other forms of payment or security that may come into Bank’s
possession; (c) sign Borrower’s name on any invoice or bill of lading relating to any Account, drafts against account debtors, schedules and assignments of Accounts, verifications of Accounts, and notices to account debtors;
(d) dispose of any Collateral; (e) make, settle, and adjust all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle and adjust disputes and claims respecting the accounts directly with account
debtors, for amounts and upon terms which Bank determines to be reasonable; (g) enter into a short-form intellectual property security agreement consistent with the terms of this Agreement for recording purposes only or modify, in its sole
discretion, any intellectual property security agreement entered into between Borrower and Bank without first obtaining Borrower’s approval of or signature to such modification by amending Exhibits A, B, and C, thereof, as appropriate, to
include reference to any right, title or interest in any Copyrights, Patents or Trademarks acquired by Borrower after the execution hereof or to delete any reference to any right, title or interest in any Copyrights, Patents or Trademarks in which
Borrower no longer has or claims to have any right, title or interest; and (h) file, in its sole discretion, one or more financing or continuation statements and amendments thereto, relative to any of the Collateral; provided Bank may exercise
such power of attorney to sign the name of Borrower on any of the documents described in clauses (g) and (h) above, regardless of whether an Event of Default has occurred. 

  
 20.

 
The appointment of Bank as Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with an interest, is irrevocable until all of the Obligations
have been fully repaid and performed and Bank’s obligation to provide advances hereunder is terminated. 
 9.3 Accounts
Collection. At any time after the occurrence and during the continuation of an Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. Borrower
shall collect all amounts owing to Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately deliver such payments to Bank in their original form as received from the account debtor, with proper endorsements for
deposit. 
 9.4 Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof of payment due to third
persons or entities, as required under the terms of this Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of the same or any part thereof; and/or (b) set up such reserves under
the Formula Revolving Line as Bank deems necessary to protect Bank from the exposure created by such failure; or (c) obtain and maintain insurance policies of the type discussed in Section 6.5 of this Agreement, and take any
action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then applicable rate hereinabove provided, and
shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver by Bank of any Event of Default under this Agreement. 

9.5 Bank’s Liability for Collateral. Bank has no obligation to clean up or otherwise prepare the Collateral for sale. All
risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 
 9.6 No Obligation to Pursue Others.
Bank has no obligation to attempt to satisfy the Obligations by collecting them from any other person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of the Obligations, all without
affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to pursue any other Person for any of the Obligations. 
 9.7 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements shall be cumulative. Bank shall have all other rights and remedies not
inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of Default on Borrower’s part shall be deemed a continuing
waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on behalf of Bank and then shall be effective only in the specific instance and for
the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived or modified by Bank by course of performance, conduct, estoppel or otherwise. 

  
 21.

 9.8 Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives
demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 
  

	 	10.	NOTICES. 

 Unless
otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered into in connection herewith shall be in writing and (except for financial statements and other informational
documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower or to
Bank, as the case may be, at its addresses set forth below: 
  

			
	If to Borrower:	  	 Osmetech Technology, Inc.

757 S. Raymond Avenue
 Pasadena, CA
91105

		
		  	Attn: Steve Kemper
		  	FAX:
                                        

		
	If to Co-Borrower:	  	 Clinical Micro Sensors, Inc.

757 S. Raymond Avenue
 Pasadena, CA
91105

		
		  	Attn: Steve Kemper
		  	FAX:
                                        

		
	If to Co-Borrower:	  	 Genmark Diagnostics, Inc.

757 S. Raymond Avenue
 Pasadena, CA
91105

		
		  	Attn: Steve Kemper
		  	FAX:
                                        

	
	with a copy (which shall not constitute notice) to:
		
		  	 DLA Piper US LLP
 4365
Executive Drive
 Suite 1100
 San Diego,
CA 92121

		  	Attn: Michael Kagnoff
		  	FAX: (858) 638-5122
		
	If to Bank:	  	 Square 1 Bank
 406 Blackwell
Street, Suite 240
 Durham, North Carolina 27701

  
 22.

			
		  	Attn: Loan Operations Manager
		  	FAX: (919) 314-3080
		
	with a copy to:	  	 Square 1 Bank
 12481 High
Bluff Drive, Suite 350
 San Diego, CA 92130

		
		  	Attn: Scott Foote
		  	FAX: (858) 436-3501

 The parties hereto may change the address at which they are to receive notices hereunder, by notice in
writing in the foregoing manner given to the other. 
  

	 	11.	CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. 

 This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of California, without regard to principles of conflicts of law. Jurisdiction shall lie in the State
of California. All disputes, controversies, claims, actions and similar proceedings arising with respect to Borrower’s account or any related agreement or transaction shall be brought in the Superior Court of San Mateo County, California or the
United States District Court for the Northern District of California, except as provided below with respect to arbitration of such matters. BANK AND BORROWER EACH ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY
BE WAIVED. EACH OF THEM, AFTER CONSULTING OR HAVING HAD THE OPPORTUNITY TO CONSULT, WITH COUNSEL OF THEIR CHOICE, KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES ANY RIGHT ANY OF THEM MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION BASED UPON OR
ARISING OUT OF THIS AGREEMENT OR ANY RELATED INSTRUMENT OR LOAN DOCUMENT OR ANY OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT OR ANY COURSE OF CONDUCT, DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN), OR ACTION OF ANY OF THEM. THESE PROVISIONS
SHALL NOT BE DEEMED TO HAVE BEEN MODIFIED IN ANY RESPECT OR RELINQUISHED BY BANK OR BORROWER, EXCEPT BY A WRITTEN INSTRUMENT EXECUTED BY EACH OF THEM. If the jury waiver set forth in this Section 11 is not enforceable, then any dispute,
controversy, claim, action or similar proceeding arising out of or relating to this Agreement, the Loan Documents or any of the transactions contemplated therein shall be settled by final and binding arbitration held in San Mateo County, California
in accordance with the then current Commercial Arbitration Rules of the American Arbitration Association by one arbitrator appointed in accordance with those rules. The arbitrator shall apply California law to the resolution of any dispute, without
reference to rules of conflicts of law or rules of statutory arbitration. Judgment upon any award resulting from arbitration may be entered into and enforced by any state or federal court having jurisdiction thereof. Notwithstanding the foregoing,
the parties may apply to any court of competent jurisdiction for preliminary or interim equitable relief, or to compel arbitration in accordance with this Section. The costs and expenses of the arbitration, including without limitation, the
arbitrator’s fees and expert witness fees, and reasonable attorneys’ fees, incurred by the parties to the arbitration may be awarded to the prevailing party, in the discretion of the arbitrator, or may be apportioned between the parties in
any manner deemed appropriate by the arbitrator. Unless 

  
 23.

 
and until the arbitrator decides that one party is to pay for all (or a share) of such costs and expenses, both parties shall share equally in the payment of the arbitrator’s fees as and
when billed by the arbitrator. 
  

	 	12.	GENERAL PROVISIONS. 

12.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of the respective successors and permitted assigns
of each of the parties and shall bind all Persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without Bank’s prior written consent, which
consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, assign, transfer, negotiate, or grant participation in all or any part of, or any interest in,
Bank’s obligations, rights and benefits hereunder. 
 12.2 Indemnification. Borrower shall defend, indemnify and
hold harmless Bank and its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement; and
(b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its officers, employees and agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under
this Agreement, or otherwise (including without limitation reasonable attorneys fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. If Bank or any other indemnified party obtains recovery of any of the
amounts that Borrowers have paid to them pursuant to the indemnity set forth herein from any insurance policies maintained by Bank or Borrowers, then Bank or such other indemnified party, as applicable, shall promptly pay to the Borrowers the amount
of such recovery that, when added to the amounts paid to them by Borrowers pursuant to the indemnity set forth herein, exceeds the maximum amount claimed by Bank or other such individual party as being owed to them pursuant to Borrowers’
indemnification obligations hereunder. 
 12.3 Time of Essence. Time is of the essence for the performance of all
obligations set forth in this Agreement. 
 12.4 Severability of Provisions. Each provision of this Agreement shall be
severable from every other provision of this Agreement for the purpose of determining the legal enforceability of any specific provision. 
 12.5 Amendments in Writing, Integration. All amendments to or terminations of this Agreement or the other Loan Documents must be in writing signed by each of Bank and [each] Borrower, or any of
such parties’ permitted successors or assigns. All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect to the subject matter of this Agreement and the other Loan Documents, if
any, are merged into this Agreement and the Loan Documents. 
 12.6 Counterparts. This Agreement may be executed in any
number of counterparts and by different parties on separate counterparts, each of which, when executed and 

  
 24.

 
delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. Executed copies of the signature pages of this Agreement
sent by facsimile or transmitted electronically in Portable Document Format (“PDF”), or any similar format, shall be treated as originals, fully binding and with full legal force and effect, and the parties waive any rights they may have
to object to such treatment. 
 12.7 Survival. All covenants, representations and warranties made in this Agreement shall
continue in full force and effect so long as any Obligations (other than inchoate obligations) remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank with respect to the
expenses, damages, losses, costs and liabilities described in Section 12.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 

12.8 Confidentiality. In handling any confidential information, Bank and all employees and agents of Bank shall exercise the same
degree of care that Bank exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any non-public information thereby received or received pursuant to this Agreement except that disclosure of such
information may be made (i) to the subsidiaries or Affiliates of Bank or Borrower in connection with their present or prospective business relations with Borrower, (ii) to prospective transferees or purchasers of any interest in the Credit
Extensions, provided that they have entered into a comparable confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar order,
(iv) as may be required in connection with the examination, audit or similar investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential information hereunder shall not
include information that either: (a) is in the public domain or in the knowledge or possession of Bank when disclosed to Bank, or becomes part of the public domain after disclosure to Bank through no fault of Bank; or (b) is disclosed to
Bank by a third party, provided Bank does not have actual knowledge that such third party is prohibited from disclosing such information. 
  

	 	13.	CO-BORROWER PROVISIONS. 

13.1 Primary Obligation. This Agreement is a primary and original obligation of each Borrower and shall remain in effect
notwithstanding future changes in conditions, including any change of law or any invalidity or irregularity in the creation or acquisition of any Obligations or in the execution or delivery of any agreement between Bank and any Borrower. Each
Borrower shall be liable for existing and future Obligations as fully as if all of all Credit Extensions were advanced to such Borrower. Bank may rely on any certificate or representation made by any Borrower as made on behalf of, and binding on,
all Borrowers, including without limitation Disbursement Request Forms, Borrowing Base Certificates and Compliance Certificates. 
 13.2 Enforcement of Rights. Borrowers are jointly and severally liable for the Obligations and Bank may proceed against one or more of the Borrowers to enforce the Obligations without waiving its
right to proceed against any of the other Borrowers. 

  
 25.

 13.3 Borrowers as Agents. Each Borrower appoints the other Borrower as its agent with
all necessary power and authority to give and receive notices, certificates or demands for and on behalf of both Borrowers, to act as disbursing agent for receipt of any Credit Extensions on behalf of each Borrower and to apply to Bank on behalf of
each Borrower for Credit Extensions, any waivers and any consents. This authorization cannot be revoked, and Bank need not inquire as to each Borrower’s authority to act for or on behalf of Borrower. 

13.4 Subrogation and Similar Rights. Notwithstanding any other provision of this Agreement or any other Loan Document, each
Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating the Borrower to the rights of Bank under the Loan Documents) to seek contribution, indemnification, or any other form of
reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by the Borrower with respect to the Obligations in connection with the Loan Documents or
otherwise and all rights that it might have to benefit from, or to participate in, any security for the Obligations as a result of any payment made by the Borrower with respect to the Obligations in connection with the Loan Documents or otherwise.
Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section 13.4 shall be null and void. If any payment is made to a Borrower in contravention of this Section 13.4, such Borrower
shall hold such payment in trust for Bank and such payment shall be promptly delivered to Bank for application to the Obligations, whether matured or unmatured. 
 13.5 Waivers of Notice. Except as otherwise provided in this Agreement, each Borrower waives notice of acceptance hereof; notice of the existence, creation or acquisition of any of the Obligations;
notice of an Event of Default; notice of the amount of the Obligations outstanding at any time; notice of intent to accelerate; notice of acceleration; notice of any adverse change in the financial condition of any other Borrower or of any other
fact that might increase the Borrower’s risk; presentment for payment; demand; protest and notice thereof as to any instrument; default; and all other notices and demands to which the Borrower would otherwise be entitled. Each Borrower waives
any defense arising from any defense of any other Borrower, or by reason of the cessation from any cause whatsoever of the liability of any other Borrower. Bank’s failure at any time to require strict performance by any Borrower of any
provision of the Loan Documents shall not waive, alter or diminish any right of Bank thereafter to demand strict compliance and performance therewith. Nothing contained herein shall prevent Bank from foreclosing on the Lien of any deed of trust,
mortgage or other security instrument, or exercising any rights available thereunder, and the exercise of any such rights shall not constitute a legal or equitable discharge of any Borrower. Each Borrower also waives any defense arising from any act
or omission of Bank that changes the scope of the Borrower’s risks hereunder. 
 13.6 Subrogation Defenses. Each
Borrower hereby waives any defense based on impairment or destruction of its subrogation or other rights against any other Borrower and waives all benefits which might otherwise be available to it under California Civil Code Sections 2809, 2810,
2819, 2839, 2845, 2848, 2849, 2850, 2899, and 3433 and California Code of Civil Procedure Sections 580a, 580b, 580d and 726, as those statutory provisions are now in effect and hereafter amended, and under any other similar statutes now and
hereafter in effect. 

  
 26.

 13.7 Right to Settle, Release. 

(a) The liability of Borrowers hereunder shall not be diminished by (i) any agreement, understanding or representation that
any of the Obligations is or was to be guaranteed by another Person or secured by other property, or (ii) any release or unenforceability, whether partial or total, of rights, if any, which Bank may now or hereafter have against any other
Person, including another Borrower, or property with respect to any of the Obligations. 
 (b) Without affecting the
liability of any Borrower hereunder, Bank may (i) compromise, settle, renew, extend the time for payment, change the manner or terms of payment, discharge the performance of, decline to enforce, or release all or any of the Obligations with
respect to a Borrower, (ii) grant other indulgences to a Borrower in respect of the Obligations, (iii) modify in any manner any documents relating to the Obligations with respect to a Borrower, (iv) release, surrender or exchange any
deposits or other property securing the Obligations, whether pledged by a Borrower or any other Person, or (v) compromise, settle, renew, or extend the time for payment, discharge the performance of, decline to enforce, or release all or any
obligations of any guarantor, endorser or other Person who is now or may hereafter be liable with respect to any of the Obligations. 
 13.8 Subordination. All indebtedness of a Borrower now or hereafter arising held by another Borrower is subordinated to the Obligations and the Borrower holding the indebtedness shall take all
actions reasonably requested by Lender to effect, to enforce and to give notice of such subordination. 
 ********

  
 27.

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above
written. 
  

			
	OSMETECH TECHNOLOGY, INC.
		
	By:	 	 /s/ Steven Kemper

		
	Title:	 	 CFO, Assistant Secretary

	
	CLINICAL MICRO SENSORS, INC.
		
	By:	 	 /s/ Steven Kemper

		
	Title:	 	 CFO, Assistant Secretary

	
	GENMARK DIAGNOSTICS, INC.
		
	By:	 	 /s/ Steven Kemper

		
	Title:	 	 CFO, Assistant Secretary

	
	SQUARE 1 BANK
		
	By:	 	 /s/ Scott R. Foote

		
	Title:	 	 SVP

  
 28.

 EXHIBIT A 
 DEFINITIONS 
 “Accounts” means all presently existing and hereafter arising accounts,
contract rights, payment intangibles and all other forms of obligations owing to Borrower arising out of the sale or lease of goods (including, without limitation, the licensing of software and other technology) or the rendering of services by
Borrower and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing. 

“Advance” or “Advances” means a cash advance or cash advances under the Formula Revolving Line. 

“Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person that controls or
is controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and general partners. 
 “Ancillary Services” means any of the following products or services requested by Borrower and approved by Bank under the Formula Revolving Line, including, without limitation, Automated
Clearing House transactions, corporate credit card services, FX Contracts, Letters of Credit, or other treasury management services. 

“Ancillary Services Sublimit” means a sublimit for Ancillary Services under the Formula Revolving Line not to exceed $500,000. 

“Authorized Officer” means someone designated as such in the corporate resolution provided by Borrower to Bank in which this Agreement and the
transactions contemplated hereunder are authorized by Borrower’s board of directors. If Borrower provides subsequent corporate resolutions to Bank after the Closing Date, the individual(s) designated as “Authorized Officer(s)” in the
most-recently provided resolution shall be the only “Authorized Officers” for purposes of this Agreement. 
 “Availability End
Date” means July 12, 2011. 
 “Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’
fees and expenses) incurred in connection with the preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses (whether generated
in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before, during and after an Insolvency Proceeding, whether or not suit is brought. 

“Borrower’s Books” means all of Borrower’s books and records including: ledgers; records concerning Borrower’s assets or
liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 
 “Borrowing Base” means an amount equal to: (i) Cash at Bank; plus (ii) 80.0% (the “Advance Rate”) of Eligible Accounts, as determined by Bank with reference to the most
recent Borrowing Base Certificate delivered by Borrower. 
 “Business Day” means any day that is not a Saturday, Sunday, or other day
on which banks in the State of North Carolina are authorized or required to close. 

  
 1. 

 “Cash” means unrestricted cash and cash equivalents. 

“Cash Burn” means an amount equal to the prior period’s Cash minus the current period’s ending Cash that has been adjusted for any
changes to Cash as a result of borrowings and repayments of borrowings, proceeds from the sale of equity and the exercise of stock options or warrants, paid-in-capital and minority interest, and capital expenditures financed under a capital lease.

 “Change in Control” shall mean a transaction other than (i) a bona fide equity financing or series of financings on terms and
from investors reasonably acceptable to Bank and (ii) any equity financing or series of financings involving the public offering of securities of Borrower in which any “person” or “group” (within the meaning of
Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all
classes of stock then outstanding of Borrower ordinarily entitled to vote in the election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power
before such transaction. 
 “Closing Date” means the date of this Agreement. 
 “Code” means the California Uniform Commercial Code as amended or supplemented from time to time. 
 “Collateral” means the property described on Exhibit B attached hereto and all Negotiable Collateral and Intellectual Property Collateral to the extent not described on Exhibit B, except to the
extent (i) any such property is nonassignable by its terms without the consent of another party (but only to the extent such prohibition on transfer is enforceable under applicable law, including, without limitation, §9406 and §9408
of the Code), (ii) the granting of a security interest in such property is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral,
(iii) any such property constitutes the capital stock of a controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes of capital stock of such controlled foreign corporations entitled to vote, or
(iv) any such property (including any attachments, accessions or replacements) that is subject to a Lien that is permitted pursuant to clause (c) of the definition of Permitted Liens, if the grant of a security interest with respect to
such property pursuant to this Agreement would be prohibited by the agreement creating such Permitted Lien or would otherwise constitute a default thereunder, provided, that such property will be deemed “Collateral” hereunder upon the
termination and release of such Permitted Lien. 
 “Collateral State” means the state or states where the Collateral is located, which
is California. 
 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise,
of that Person with respect to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold
with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate credit cards or merchant services issued for the account of
that Person; and (iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement designated to protect a Person against
fluctuation in interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course of business. The amount of
any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably anticipated
liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the obligations under the guarantee or other support arrangement. 

  
 2. 

 “Copyrights” means any and all copyright rights, copyright applications, copyright registrations
and like protections in each work or authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held. 

“Credit Extension” means each Advance, Equipment Advance, or any other extension of credit, by Bank to or for the benefit of Borrower
hereunder. 
 “Current Assets” means, as of any applicable date, all amounts that should, in accordance with GAAP, be included as
current assets on the consolidated balance sheet of Borrower and its Subsidiaries as at such date. 
 “Current Ratio” means
(i) Current Assets; divided by (ii) Formula Advances then outstanding. 
 “Eligible Accounts” means those Accounts
that arise in the ordinary course of Borrower’s business that comply with all of Borrower’s representations and warranties to Bank set forth in Section 5.3; provided, that Bank may change the Advance Rate and the standards of
eligibility by giving Borrower 10 days prior written notice. Unless otherwise agreed to by Bank, Eligible Accounts shall not include the following: 
 (a) Account balances that the account debtor has failed to pay in full within 90 days of invoice date; 
 (b) Account credit balances greater than 90 days from invoice date; 

(c) Accounts with respect to an account debtor, 25% of whose Accounts the account debtor has failed to pay within 90 days of
invoice date; 
 (d) Accounts with respect to an account debtor, including the account debtor’s subsidiaries and
Affiliates, whose total obligations to Borrower exceed 25% of all Accounts, to the extent such obligations exceed the aforementioned percentage, except as approved in writing by Bank; 

(e) Accounts with respect to which the account debtor does not have its principal place of business in the United States, except
for Eligible Foreign Accounts; 
 (f) Accounts with respect to which the account debtor is the United States or any
department, agency, or instrumentality of the United States, except for Accounts of the United States if the payee has assigned its payment rights to Bank and the assignment has been acknowledged under the Assignment of Claims Act of 1940 (31 U.S.C.
3727); 
 (g) Accounts with respect to which Borrower is liable to the account debtor for goods sold or services rendered
by the account debtor to Borrower, but only to the extent of any amounts owing to the account debtor against amounts owed to Borrower; 
 (h) Accounts with respect to which the account debtor is an officer, employee, agent, Subsidiary or Affiliate of Borrower; 
 (i) Accounts with respect to which goods are placed on consignment, guaranteed sale, sale or return, sale on approval, bill and hold, demo or promotional, or other terms by reason of which the
payment by the account debtor may be conditional 
 (j) “Advanced Billings,” i.e., accounts that have not yet
been billed to the account debtor or that relate to deposits (such as good faith deposits) or other property of the account debtor held by Borrower for the performance of services or delivery of goods which Borrower has not yet performed or
delivered; 

  
 3. 

 (k) Accounts with respect to which the account debtor disputes liability or makes any
claim with respect thereto as to which Bank believes, in its sole discretion, that there may be a basis for dispute (but only to the extent of the amount subject to such dispute or claim), or is subject to any Insolvency Proceeding, or becomes
insolvent, or goes out of business; 
 (l) Accounts the collection of which Bank reasonably determines after inquiry and
consultation with Borrower to be doubtful; 
 (m) Retentions and hold-backs; and 

(n) “Progress Billings,” i.e., accounts that are billed based on project milestones and not on actual time and materials
bases. 
 “Eligible Foreign Accounts” means Accounts: (x) with respect to which the account debtor does not have its principal
place of business in the United States; and (y) which do not otherwise fall within any of subsections (a) through (d) and (f) through (n) of the definition of “Eligible Accounts”, and that are: (i) supported
by one or more letters of credit in an amount and of a tenor, and issued by a financial institution, acceptable to Bank, (ii) insured by the Export Import Bank of the United States, (iii) generated by an account debtor with its principal
place of business in Canada, except for the Province of Quebec, or (iv) approved by Bank on a case-by-case basis. All Eligible Foreign Accounts must be calculated in U.S. Dollars, and must be billed by the Borrower from a location within
the United States of America. “Equipment” means all present and future machinery, equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and attachments in which Borrower has any interest. 

“Equipment” means all present and future machinery, equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and attachments
in which Borrower has any interest. 
 “Equipment Advance(s)” means a cash advance or cash advances under the Equipment Loan.

 “Equipment Loan” means a Credit Extension of up to $2,000,000 in the aggregate, subject to the restrictions that: (i) no more
than $500,000 may be advanced to finance licensed genetic bio-markers; (ii) no more than $550,000 may be advanced to finance leasehold improvements or other new building-related capital expenditures. 

“Equipment Maturity Date” means July 12, 2013. 
 “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations thereunder. 
 “Event of Default” has the meaning assigned in Article 8. 
 “Formula Advance”
or “Formula Advances” means a cash advance or cash advances under the Formula Revolving Line. 
 “Formula Revolving Line”
means a Credit Extension of up to $2,000,000 (inclusive of any amounts outstanding under the Ancillary Services Sublimit). 
 “Formula
Revolving Maturity Date” means July 12, 2011. 

  
 4. 

 “Foreign Exchange Reserve Percentage” means a percentage of reserves for FX Contracts as
determined by Bank, in its sole discretion from time to time. 
 “FX Contracts” means contracts between Borrower and Bank for foreign
exchange transactions. 
 “GAAP” means generally accepted accounting principles, consistently applied, as in effect from time to time
in the United States. 
 “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property
or services, including without limitation reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease
obligations, and (d) all Contingent Obligations, including but not limited to any sublimit contained herein. 
 “Insolvency
Proceeding” means any proceeding commenced by or against any Person or entity under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of
creditors, formal or informal moratoria, compositions, extension generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 
 “Intellectual Property Collateral” means all of Borrower’s right, title, and interest in and to the following: 
 (a) Copyrights, Trademarks and Patents; 
 (b) Any and all trade
secrets, and any and all intellectual property rights in computer software and computer software products now or hereafter existing, created, acquired or held; 
 (c) Any and all design rights which may be available to Borrower now or hereafter existing, created, acquired or held; 
 (d) Any and all claims for damages by way of past, present and future infringement of any of the rights included above, with the right, but not the obligation, to sue for and collect such damages
for said use or infringement of the intellectual property rights identified above; 
 (e) All licenses or other rights to
use any of the Copyrights, Patents or Trademarks, and all license fees and royalties arising from such use to the extent permitted by such license or rights; 
 (f) All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents; and 
 (g) All proceeds and products of the foregoing, including without limitation all payments under insurance or any indemnity or warranty payable in respect of any of the foregoing. 

“Inventory” means all present and future inventory in which Borrower has any interest. 

“Investment” means any beneficial ownership of (including stock, partnership or limited liability company interest or other securities) any
Person, or any loan, advance or capital contribution to any Person. 
 “Investment Agreement” means, collectively, Borrower’s
stock purchase and other agreement(s) pursuant to which Borrower most recently issued shares of its preferred stock. 
 “IRC” means
the Internal Revenue Code of 1986, as amended, and the regulations thereunder. 
 “Letter of Credit” means a commercial or standby
letter of credit or similar undertaking issued by Bank at Borrower’s request. 

  
 5. 

 “Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other similar
encumbrance. 
 “Liquidity” means the sum of: (i) unrestricted Cash in Bank; plus (ii) 50.0% of Accounts in the United
States; plus (iii) contingent on the aggregate amount of Borrowers’ Cash at Bank being at least $10,000,000, Cash in other banks that is subject to an account control agreement in favor of and in form and substance acceptable to Bank.

 “Liquidity Ratio” means the ratio of Liquidity to all Indebtedness to Bank. 

“Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and any other document, instrument or agreement
entered into in connection with this Agreement, all as amended or extended from time to time. 
 “Material Adverse Effect” means a
material adverse effect on: (i) the operations, business or financial condition of Borrower and its Subsidiaries taken as a whole; (ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under the Loan
Documents; or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s security interest in the Collateral. 

“Negotiable Collateral” means all of Borrower’s present and future letters of credit of which it is a beneficiary, drafts, instruments
(including promissory notes), securities, documents of title, and chattel paper, and Borrower’s Books relating to any of the foregoing. 

“Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to Bank by Borrower pursuant to this Agreement or any
other agreement, whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest that accrues after the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing
from Borrower to others that Bank may have obtained by assignment or otherwise. 
 “Patents” means all patents, patent applications
and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 
 “Periodic Payments” means all installments or similar recurring payments that Borrower may now or hereafter become obligated to pay to Bank pursuant to the terms and provisions of any
instrument, or agreement now or hereafter in existence between Borrower and Bank. 
 “Permitted Indebtedness” means: 

(a) Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan Document; 

(b) Indebtedness existing on the Closing Date and disclosed in the Schedule; 

(c) Indebtedness not to exceed $350,000 in the aggregate in any fiscal year of Borrower secured by a lien described in clause
(c) of the defined term “Permitted Liens,” provided such Indebtedness does not exceed at the time it is incurred the lesser of the cost or fair market value of the property financed with such Indebtedness; 

(d) Subordinated Debt; 

  
 6. 

 (e) Indebtedness to trade creditors incurred in the ordinary course of business;

 (f) Indebtedness of Borrower to any Subsidiary and Contingent Obligations of any Subsidiary with respect to
obligations of Borrower, Indebtedness of any Subsidiary to any other Subsidiary and Contingent Obligations of any Subsidiary with respect to obligations any other Subsidiary, and Indebtedness of any Subsidiary to Borrower; 

(g) Indebtedness of Borrower in respect of performance bonds, bid bonds, appeal bonds, surety bonds, bankers’ acceptances and
similar obligations and trade-related letters of credit, in each case provided in the ordinary course of business and not in connection with Indebtedness for money borrowed; and 

(h) Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not
increased or the terms modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be. 
 “Permitted
Investment” means: 
 (a) Investments existing on the Closing Date disclosed in the Schedule; 

(b) (i) Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or
any State thereof maturing within one year from the date of acquisition thereof, (ii) commercial paper maturing no more than one year from the date of creation thereof and currently having rating of at least A-2 or P-2 from either
Standard & Poor’s Corporation or Moody’s Investors Service, (iii) repurchase agreements relating to securities issued or guaranteed as to principal and interest by the United States of America, (iv) mutual funds that
invest solely in investments of the type described in clauses (i), (ii), or (iii) above, (v) Bank’s certificates of deposit maturing no more than one year from the date of investment therein, and (vi) Bank’s money market
accounts; (vii) Investments in regular deposit or checking accounts held with Bank or subject to a control agreement in favor of Bank; and (viii) Investments consistent with any investment policy adopted by the Borrower’s board of
directors; 
 (c) Repurchases of stock from former employees, consultants or directors of Borrower under the terms of
applicable repurchase agreements (i) in an aggregate amount not to exceed $350,000 in any fiscal year, provided that no Event of Default has occurred, is continuing or would exist after giving effect to the repurchases, or (ii) in any
amount where the consideration for the repurchase is the cancellation of indebtedness owed by such former employees, consultants or directors to Borrower regardless of whether an Event of Default exists; 

(d) Investments accepted in connection with Permitted Transfers; 

(e) Investments of Subsidiaries in or to other Subsidiaries or Borrower, and Investments by Borrower in Subsidiaries not to exceed
$350,000 in the aggregate in any fiscal year; 
 (f) Investments not to exceed $350,000 outstanding in the aggregate at
any time consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business, and (ii) loans to employees, officers or directors relating to the purchase of equity
securities of Borrower or its Subsidiaries pursuant to employee stock purchase plan agreements approved by Borrower’s Board of Directors; 
 (g) Investments in unfinanced capital expenditures in any fiscal year, not to exceed $350,000; 

  
 7. 

 (h) Investments (including debt obligations) received in connection with the
bankruptcy or reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; 

(i) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers
who are not Affiliates, in the ordinary course of business, provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary; 
 (j) Investments in prepaid expenses, negotiable instruments held for collection, and deposits to secure the performance of bids, trade contracts (other than for borrowed money), contracts for the
purchase of property, leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature, in each case, incurred in the ordinary course of business and not representing an obligation for borrowed money;

 (k) Joint ventures or strategic alliances in the ordinary course of Borrower’s business consisting of the
non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash Investments by Borrower do not exceed $350,000 in the aggregate in any fiscal year; and 

(l) Investments permitted under Section 7.3. 
 “Permitted Liens” means the following: 
 (a) Any Liens existing
on the Closing Date and disclosed in the Schedule (excluding Liens to be satisfied with the proceeds of the Credit Extensions) or arising under this Agreement, the other Loan Documents, or any other agreement in favor of Bank; 

(b) Liens for taxes, fees, assessments or other governmental charges or levies, either not delinquent or being contested in good
faith by appropriate proceedings and for which Borrower maintains adequate reserves; 
 (c) Liens not to exceed $350,000
in the aggregate (i) upon or in any Equipment and related software (other than Equipment financed by a Credit Extension) acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment and related software
or indebtedness incurred solely for the purpose of financing the acquisition or lease of such Equipment and related software, or (ii) existing on such Equipment and related software at the time of its acquisition, in each case provided that the
Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such Equipment and related software; 
 (d) Liens incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type described in clauses (a) through (c) above, provided that any
extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced does not increase; 

(e) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Sections 8.4
(attachment) or 8.7 (judgments); 
 (f) Liens securing Subordinated Debt; 

(g) Deposits under worker’s compensation, unemployment insurance, social security and other similar laws, or to secure the
performance of bids, tenders or 

  
 8. 

 
contracts (other than for the repayment of borrowed money) or to secure indemnity, performance or other similar bonds for the performance of bids, tenders or contracts (other than for the
repayment of borrowed money) or to secure statutory obligations (other than liens arising under ERISA or environmental liens) or surety or appeal bonds, or to secure indemnity, performance or other similar bonds in the ordinary course of business;

 (h) Liens arising out of leases or subleases and licenses and sublicences granted to others in the ordinary course of
Borrower’s business not interfering in any material respect with the business of Borrower and its Subsidiaries taken as a whole; 
 (i) Easements, reservations, rights-of-way, restrictions, minor defects or irregularities in title and other similar changes or encumbrances affecting real property not constituting a Material
Adverse Effect on Borrower’s and its Subsidiaries’ business, taken as a whole; and 
 (j) Liens of materialmen,
mechanics, warehousemen, carriers, artisans or other similar Liens arising in the ordinary course of business or by operation of law. 
 (k) Subject to Section 6.6, Liens in favor of other financial institutions arising in connection with Borrower’s deposit accounts held at such institutions to secure standard fees
for deposit services charged by, but not financing made available by such institutions, provided that Bank has a perfected security interest in the amounts held in such deposit accounts. 
 “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or any Subsidiary of: 
 (a) Inventory in the ordinary course of business; 
 (b) licenses and
similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of business; 
 (c)
worn-out, surplus or obsolete Equipment not financed with the proceeds of Credit Extensions; 
 (d) grants of
security interests and other Liens that constitute Permitted Liens; 
 (e) other assets of Borrower or its Subsidiaries
that do not in the aggregate exceed $350,000 during any fiscal year; 
 (f) Borrower’s property as permitted under
Sections 7.6, 7.7 and 7.8; and 
 (g) amounts by Borrower to or from one of its investment or deposit accounts to another
investment or deposit account maintained with Bank. 
 “Person” means any individual, sole proprietorship, partnership, limited
liability company, joint venture, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 

“Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank, as its “prime rate,” whether or not
such announced rate is the lowest rate available from Bank. 
 “Responsible Officer” means each of the Chief Executive Officer, the
Chief Operating Officer, the Chief Financial Officer, Vice President of Finance and the Controller of Borrower, as well as any other officer or employee identified in as an Authorized Officer in the corporate resolution delivered by Borrower to Bank
in connection with this Agreement. 

  
 9. 

 “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any.

 “Shares” means (i) sixty-five percent (65%) of the issued and outstanding capital stock, membership units or other
securities owned or held of record by Borrower in any Subsidiary of Borrower which is not an entity organized under the laws of the United States or territory thereof, and (ii) one hundred percent (100%) of the issued and outstanding
capital stock, membership units or other securities owned or held of record by Borrower in any Subsidiary of Borrower which is an entity organized under the laws of the United States or any territory thereof 

“SOS Reports” means the official reports from the Secretaries of State of each Collateral State, the state where Borrower’s chief
executive office is located, the state of Borrower’s formation and other applicable federal, state or local government offices identifying all current security interests filed in the Collateral and Liens of record as of the date of such report.

 “Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt owing by Borrower to Bank on
terms reasonably acceptable to Bank (and identified as being such by Borrower and Bank). 
 “Subsidiary” means any corporation,
partnership or limited liability company or joint venture in which (i) any general partnership interest or (ii) more than 50% of the stock, limited liability company interest or joint venture of which by the terms thereof ordinary voting
power to elect the Board of Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower, either directly or through an Affiliate. 

“Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same and
like protections, and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks. 

  
 10.

			
	DEBTOR:	  	OSMETECH TECHNOLOGY, INC.
		
	SECURED PARTY:	  	SQUARE 1 BANK

 EXHIBIT B-1 
 COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 
 All personal property of
Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

(a) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper),
deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names,
and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions), investment property
(including securities and securities entitlements but limited to sixty-six two-thirds percent (66 2/3%) of the outstanding equity securities of any subsidiary formed in a jurisdiction outside of the United States), letter of credit rights, money,
and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and records; 
 (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and all supporting obligations and the security therefor or for any
right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions. 

  
 1. 

			
	DEBTOR:	  	GENMARK DIAGNOSTICS, INC.
		
	SECURED PARTY:	  	SQUARE 1 BANK

 EXHIBIT B-2 
 COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 
 All personal property of
Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

(c) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper),
deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names
and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions), investment property
(including securities and securities entitlements but limited to sixty-six two-thirds percent (66 2/3%) of the outstanding equity securities of any subsidiary formed in a jurisdiction outside of the United States), letter of credit rights, money,
and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and records; 
 (d) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and all supporting obligations and the security therefor or for any
right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions. 

  
 1. 

			
	DEBTOR:	  	CLINICAL MICRO SENSORS, INC.
		
	SECURED PARTY:	  	SQUARE 1 BANK

 EXHIBIT B-3 
 COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 
 All personal property of
Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

(e) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper),
deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names
and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions), investment property
(including securities and securities entitlements but limited to sixty-six two-thirds percent (66 2/3%) of the outstanding equity securities of any subsidiary formed in a jurisdiction outside of the United States), letter of credit rights, money,
and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and records; 
 (f) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and all supporting obligations and the security therefor or for any
right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions. 

  
 1. 

 EXHIBIT C 

 
 

 
  

															
							
		 	Sent to |	  	 	  	 	  	Date |	  	 	Time |	  	  	 
				
		 	 Requested Transaction
  
	  				  	
		 	 	 	 	 	 
		 	BORROWER	  	 Osmetech Technology, Inc
	  		  	REQUESTED TRANSACTION TYPE	  	 	DOLLAR AMOUNT	  	  	 
		 					 
		 	FROM Account No.	  	  
	  		  	Principal Increase (Advance)	  	$	—  	  	  	 
		 		  		  		  		  	  
	  
	 	  	 
		 		  		  		  	Principal Payment (Only)	  	$	—  	  	  	 
		 		  		  		  		  	  
	  
	 	  	 
		 	TO Account No.	  	  
	  		  		  				  	 
		 	  

Borrower’s total Cash as of the date of this
 certificate (including Cash held outside of
	  		  	Other Instructions:	  				  	 
		 	Square 1 Bank, if any)	  	 $  —  
	  		  		  				  	 
		 			 
		 	 X
	  		  			  	 
		 	borrower authorized signature	  			  	 
		 	  
 NOTE: THE PERSON SIGNING THIS ADVANCE
REQUEST MUST BE LISTED AS AN AUTHORIZED OFFICER IN THE BORROWING RESOLUTIONS EXECUTED BY THE COMPANY IN CONNECTION WITH THE LOAN AND SECURITY AGREEMENT
	  			  	 
		 	  			  	 
		 	  			  	 
		 	  			  	 
		 	  			  	 
		 	  			  	 
		 	  			  	 
		 	  		  				  	 
		 	  
	  		  		  				  	 
		 	authorized requestor	  	phone number	  		  		  				  	 
		 					 
		 	 	  	 	  	 	  	 	  	 	 	 	  	 

  

			
		 	 All representations and warranties of Borrower stated in the Loan Agreement are true, correct and complete in all material respects
as of the date of the request for, and advance confirmed by, this Loan Advance / Paydown Request; provided that those representations and warranties of the date expressly referring to another date shall be true, correct and complete in all material
respects as of such date.
  
 Outgoing Wire Transfer
Instructions
  
 Is there a wire request tied to this loan
advance? Please
circle:                                       
             YES        NO

If there is a wire associated, please complete the necessary fields below. By filling out the fields below you are requesting Square 1 Bank to initiate
the wire on your behalf, in which case an authorized person(s) will be contacted by Square 1 Bank for PIN and wire confirmation based on the instruction you provided to the Bank within your Funds Transfer Agreement.

 
 All fields below must be completed for an associated wire to go out of your
account (subject to wire confirmation with PIN).

 
  

													
		 	  
 WIRE AMOUNT
  
	  	 $
	  	 	  	FROM ACCOUNT NO.	  	  
	  	 
		 	 Beneficiary Name
  
	  	  
	  		  	ABA Routing No. (9 digits)	  	  
	  	 
		 	 Beneficiary Account No.

 
	  	  
	  		  	Receiving Institution Name	  	  
	  	 
		 	 Beneficiary Address
  
	  	  
	  		  	Receiving Institution Address	  	  
	  	 
		 		  	  
	  		  		  	  
	  	 
		 					 
		 	 	  	 	  	 	  	 	  	 	  	 
		 	  

COMMENTS TO BENEFICIARY
	  	 
		 	 
		 	 	  	 

 For Bank Use Only 
  

															
		 	  
 TRANSACTION
REQUEST
	  	 	  	 	  	OUTGOING WIRE TRANSFER
		 				 	 
		 	date received	 	  
	  	comp. status	  	  
	  	 	  	 X

		 	time received	 	  
	  	status date	  	  
	  	 	  	wire approval signature
		 	 	 
		 	 X
	  	 	  	wire posted               
                 YES            NO
		 	 analyst signature
	  	 	  		  	 
		 	 		 
		 	 X
	  	 	  	date	  	  

		 	 manager’s approval signature
	  	 	  	time	  	  

		 	 	 	 	  	 	  	 	  	 	  	 	  	 
		 	  
 TELEPHONE REQUEST
	  	 	  	 p. bal. |

		 		 		  		  		  	 	  	 p. no. |

		 	 received by |
	  	 	  	 p. notes |

		 	 	 	 	  	 	  	 	  	 	  	 	  	 

  

					
	Square 1 Bank Confidential	 		 	New Borrower’s Kit V 1.1

  
 2. 

 EXHIBIT D 

 
 

 
  

													
		 		  	 Borrower |    Osmetech Technology, Inc
	  	 	Commitment Amount |	  	  	$	2,000,000	  
					
		 		  	 Accounts Receivable
	  				  			
				
		 	 1.
	  	 Accounts Receivable Book Value as of
                date |                    

	   
	  	$	                    —  	  
		 		  		  				  	  
	  
	 
		 	 2.
	  	 Additions (please explain on reverse)
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 3.
	  	 TOTAL ACCOUNTS RECEIVABLE
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
				
		 		  	 Accounts Receivable Deductions (without duplication)
	   
	  			
					
		 	 4.
	  	 Amounts over 90 days
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 5.
	  	 Credit balances over 90 days
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 6.
	  	 Balance of 25% over 90 days
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 7.
	  	 Concentration limits
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 8.
	  	 Foreign Accounts
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 9.
	  	 Government Accounts
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 		  	    (except Assigned Government Contracts)	  				  			
		 	 10.
	  	 Contra Accounts
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 11.
	  	 Demo Accounts
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 12.
	  	 Intercompany/Employee Accounts
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 13.
	  	 Advance Billings
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 14.
	  	 Progress Billings
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 15.
	  	 Other (please explain below)
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 16.
	  	 Total Accounts Receivable Deductions
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 17.
	  	 Eligible Accounts (#3 Minus #16)
	  	$	—  	  	  			
		 		  		  	  
	  
	 	  			
		 	 18.
	  	 Loan Value of Accounts Receivable ( 80 % of #17)
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
					
		 		  	 Balances
	  				  			
		 	 19.
	  	 Maximum Loan Amount
	  	$	2,000,000.00	  	  			
		 		  		  	  
	  
	 	  			
		 	 20.
	  	 Total Unrestricted Cash at Bank
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 21.
	  	 Total Funds Available
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 22.
	  	 Present balance outstanding on Line of Credit
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 23.
	  	 Outstandings under Sublimits (Letters of Credit)
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	 24.
	  	 Reserve Position
	  				  	$	—  	  
		 		  		  				  	  
	  
	 
		 	  
 The undersigned represents and warrants that the
foregoing is true, complete and correct, and that the information reflected in this Borrowing Base Certificate complies with the representations and warranties set forth in the Loan & Security Agreement between the undersigned and Square 1
Bank.
  
	 
     

		 		  	 Comments
	  				  			

 
	
	 
	 

  

							
				
	 X
	  		  	bank	  	Square 1 Bank
	authorized signature	  		  	address	  	ATTN: Portfolio Analysis Dept.
		  		  		  	 406 Blackwell St. Suite 240

Durham, NC 27701

	 name |
	  		  	web link	  	www.square1bank.com
		  		  	phone	  	919-314-3040
	 title |
	  		  	fax	  	919-314-3090
		  		  	email	  	reportsed@square1bank.com

 

							
	 For Bank Use Only

 

	  

received by |
	 	date |	 	reviewed by |	 	date |

  

					
	Square 1 Bank Confidential	 		 	New Borrower’s Kit v 1.1

  
 3. 

  
 EXHIBIT E 

 
 

 
  

																									
		 		 	Borrower  	  	Osmetech Technology, Inc
		 	  
 The undersigned authorized Officer of
                     (“Borrower”), hereby certifies that in accordance with the terms and conditions of the Loan and Security Agreement
between Borrower and Bank (the “Agreement”), (i) Borrower is in complete compliance for the period ending                     , with all
covenants except as noted below; and (ii) all representations and warranties of Borrower stated on the Agreement are true and correct as of the date hereof. Attached herewith are the required documents supporting the above certification. The Officer
further certifies that these are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next, except as explained in an accompanying letter or footnotes.

 

		 		 	        Reporting Covenants
		
		 	 Please indicate compliance status by circling YES or NO under the COMPLIES
column.
  

		 	  

COVENANTS
  
	  	 REQUIRED

 
	  	 	  	 COMPLIES

 

		 	 Monthly financial statements, Compliance Cert.
	  	Monthly, within 30 days	  		  	YES	  	NO
		 	 A/R & A/P Agings, Borrowing Base Cert.
	  	Monthly, within 30 days	  		  	YES	  	NO
		 	 IP Report
	  	Quarterly, within 30 days	  		  	YES	  	NO
		 	 A/R Audit
	  	Initial and Semi-Annual	  		  	YES	  	NO
		 	 Annual (CPA Audited)
	  	FYE within 180 days	  		  	YES	  	NO
		 	 10K and 10Q
	  	(as applicable)	  		  	YES	  	NO
		 	 Annual Financial Projections

 
	  	 November 30 of each year

 
	  	 	  	 YES

 
	  	NO
 

		 		 	  

        Banking Relationship

		
		 	 Please Banking Relationship below and circle YES or NO under the COMPLIES column.

 

		 	 	 	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	  

COMPLIES
	  	 
		 	Total Amount of Borrower’s Cash and Investments at S1B	  	
                    
 
	  		  		  	 
		 	All Cash and Investments at S1B?	  		  		  	YES	  	NO
		 		 	If no, total amount of Borrower’s Cash and Investments outside of S1B	  		  	  
	  		  		  	 
		 		 	Location of Cash & Investments outside of S1B	  	  
	  		  		  	 
		 				 
		 	Total amount of Borrower’s Cash and Investments	  	
                    
                     
	  		  		  	 
		 				 
		 	 	  	 	  	 	  	 	  	 
		 		 	  

        Financial Covenants
	  		  		  		  		  		  		  		  		  	
		
		 	 Please list financial covenants below and circle YES or NO under the COMPLIES column.

 

		 	 COVENANTS
	  	 	  	REQUIRED	  	ACTUAL	  	COMPLIES
		 								 
		 	 Liquidity Ratio
	  		  	1.50	  		  		  		  	YES	  	NO	  	NA
		 								 
		 	 Current Ratio
	  		  	1.50	  		  		  		  	YES	  	NO	  	NA
		 							 
		 	 Trailing 3 Mo. Cash Burn

 
	  	 	  	See Covenant Worksheet
 
	  	 	  	 	  	YES  
	  	 NO

 
	  	NA  

		
		 	 Please enter comments regarding covenant violations

 

		 
		 	 
		 	  
 By signing below, the Officers further acknowledge
that at any time Borrower is not in compliance with all the terms set forth in the Agreement, including, without limitation, the financial covenants, and such non-compliance results in a Default or Event of Default and such Default or Event of
Default is continuing, then no credit extensions will be made.
  

 
															
		 		 		  		  		  	 Please Send All Required Reporting to:
  

	 X
	 		  	
                 

	  		  		  	address	  	 Square 1 Bank
  

	authorized signature	 		  	date	  		  		  		  	 ATTN: Portfolio Analysis Dept.

 

		 		  		  		  		  		  	 406 Blackwell St. Suite 240

 

	 name:
	 		  		  		  		  		  	 Durham, NC 27701
  

		 		 		  		  		  		  	web link	  	 www.square1bank.com
  

	 title:
	 		  		  		  		  	phone	  	 919-314-3040
  

		 		 		  		  		  		  	fax	  	 919-314-3090
  

		 		 		  		  		  		  	email	  	 reportsed@square1bank.com

 

 
																											
												
		 		 		  	For Bank Use Only	  				  		  		  		  		  				  		 	
	 	 	  
   received by |
	  	 	date |	  	  	 	  	 	  	reviewed by |	  	 	  	 	date |	  	  	 	 	 
	 	 	  

  financial compliance status:
  
	  	   
	YES  
	    
	  	 NO

 
	  	 	  	 	  	 	  	 	 	 	  	 	 	 

  

					
	Square 1 Bank Confidential	 		 	New Borrower’s Kit v 1.1

  
 4.Settlement and Release Agreement

 Exhibit 10.18 
 SETTLEMENT AND RELEASE AGREEMENT 
 AND SECOND AMENDMENT TO LEASE

 [THE CAMPUS CARLSBAD] 

THIS SETTLEMENT AND RELEASE AGREEMENT AND SECOND AMENDMENT TO LEASE (“Second Amendment”) is made and
entered into as of the 19th day of January, 2012
(“Effective Date”), by and between THE CAMPUS CARLSBAD, LLC, a Delaware limited liability company (“Landlord”) and CLINICAL MICRO SENSORS, INC., a Delaware corporation dba “GENMARK DIAGNOSTICS, INC.”
(“Tenant”). Landlord and Tenant are sometimes hereinafter collectively referred to as the “Parties” or, individually, a “Party.” 

R E C I T A L S: 

A. Landlord and Tenant (formerly dba “Osmetech Molecular Diagnostics”) entered into that certain Lease — The Campus
dated as of February 8, 2010 (the “Original Lease”), whereby Landlord leased to Tenant and Tenant leased from Landlord certain space located in that certain building located and addressed at 5964 La Place Court, Carlsbad,
California (the “Building”). 
 B. The Original Lease was subsequently amended by that certain Settlement and
Release Agreement and First Amendment to Lease dated July 1, 2010, by and between Landlord and Tenant (“First Amendment”), with Tenant erroneously named therein as “GenMark Diagnostics, Inc., a Delaware corporation”
(i.e., Tenant’s dba name, rather than Tenant’s legal name). The Original Lease, as amended by the First Amendment and this Second Amendment, may be referred to herein as the “Lease.” 

C. Certain disputes have arisen between Landlord and Tenant regarding (a) Tenant’s exercise of its right to lease the Expansion
Space (as defined in Section 1.4 of the Original Lease and modified by Clause (a) of Section 2 of this Second Amendment below) in accordance with Section 1.4 of the Original Lease in August 2011, and Landlord’s response to
Tenant’s delivery of written notice to Landlord exercising its right to expand the Existing Premises (as defined in Section 4 of this Second Amendment) to incorporate the Expansion Space on the terms and conditions of Section 1.4 of
the Original Lease (the “Expansion Claims”); and (b) Tenant’s failure to pay Landlord a monthly fee in connection with Tenant’s occupancy and use of portions of the Expansion Space for storage and warehousing purposes
prior to the Effective Date commencing on or about July 15, 2010 and continuing as of the Effective Date of this Second Amendment (the “Warehouse Claims”). Collectively, the Expansion Claims and Warehouse Claims are referred to
herein as the “Second Amendment Disputes.” 
 D. By this Second Amendment, the Parties now desire to:
(i) resolve their disputes relating to the Second Amendment Disputes without the delay, inconvenience, expense and uncertainty of formal legal proceedings and without any admissions by either Landlord or Tenant as to the correctness,
incorrectness, propriety, or impropriety of any claim, allegation, statement, position, conduct, act, or omission made or done heretofore by either Landlord or Tenant or their respective agents and/or representatives in connection with the Second
Amendment Disputes; (ii) amend and restate the First Amendment for the sole purpose of correcting the name of the Tenant as erroneously referenced therein; (iii) provide for certain improvements to be made by Landlord to the Building for
the expansion of the existing mezzanine space located within the Expansion Space as part of the Landlord’s Mezzanine Work (as defined in as defined in Section 6 of this Second Amendment); (iv) provide for the expansion of the Existing
Premises currently as of the date of this Second Amendment, leased by Tenant in the Building to incorporate the Expansion Space (as further expanded by Landlord’s expansion of the existing mezzanine space located therein as part of the
Landlord’s Mezzanine Work); (v) clarify and extend the Lease Term for the entire Premises (i.e., the Existing Premises as expanded by the Expansion Space); (vi) provide for Tenant’s prior and continued use of the Expansion
Space, for the period commencing on July 15, 2010 and ending on the Warehouse Expiration Date (as defined in Section 11(b) of this Second Amendment), solely for the Warehouse License Permitted Use (as defined in Section 11(b) of this
Second Amendment); (vii) revise Section 13 of the Original Summary (as defined in Section 2 below) to partially reduce the number of parking passes to which Tenant is currently entitled under the Lease to reflect that sixteen
(16) parking spaces of the Parking Area (the “Equipment Area Spaces”) are currently as of the Effective Date, encumbered by Tenant’s Common Area Equipment (for as long as, and to the extent that, the Equipment Area Spaces

 
remain so encumbered, subject to the terms and conditions of Section 5 of the First Amendment); (viii) increase the amount of the Security Deposit and the Stated Amount of the Letter of
Credit required to be delivered by Tenant to Landlord pursuant to Article 21 of the Original Lease and (ix) otherwise modify the Lease as provided herein. 
 E. Unless otherwise defined herein, capitalized terms as used herein shall have the same meanings as given thereto in the Original Lease as modified by the First Amendment. 

NOW, THEREFORE, in consideration of the foregoing recitals and the mutual covenants contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 
 A G R
E E M E N T: 
 1. Amendment and Restatement of First Amendment. Landlord and Tenant hereby acknowledge and agree that at
the time of the First Amendment, the Tenant entity named in this Second Amendment was, and continues (as of the Effective Date) to be, the sole tenant of the Existing Premises and the sole lessee of the leasehold estate created by the Original Lease
(as amended by the First Amendment). Notwithstanding the execution of the First Amendment by Tenant as “GenMark Diagnostics, Inc., a Delaware corporation,” Tenant hereby represents and warrants to Landlord that: (a) the officer of
Tenant who executed the First Amendment was authorized by Tenant to do so on behalf of the Tenant entity in accordance with Tenant’s by laws and corporate requirements; and (b) Tenant has performed all of the Tenant’s obligations
under the First Amendment as if Tenant was the party named therein. Landlord and Tenant hereby restate all of the terms and conditions of the First Amendment as an agreement by and between them by this reference, subject to the modifications thereto
set forth in this Section 1 of this Second Amendment. 
 2. Amendments to Basic Lease Information. Effective as of
the Effective Date, the Summary of Basic Lease Information of the Original Lease (the “Original Summary”) is hereby modified as follows to reflect the terms of this Second Amendment. 

Tenant’s Trade Name in Section 4 of the Original Summary is hereby changed to “GenMark Diagnostics, Inc.,” and
Section 5 of the Original Summary is also hereby modified to reflect such name change for purposes of notices delivered to Tenant pursuant to the Lease (as amended hereby); 

(a) Section 6 of the Original Summary is hereby modified as follows: 

 

	 “6. Premises (Article 1): 
	From the Lease Commencement Date (as such term is modified by Clause (d) of this Section 2 below) until the date immediately prior to the Expanded Premises Commencement Date (as
defined in Clause (d) of this Section 2 below), 31,098 square feet of space located in the Building, as set forth in Exhibit “A” attached hereto, and known as Suite 100 of the Building. For purposes of this
Second Amendment, for the portion of the Lease Term preceding the Expanded Premises Commencement Date, the “Premises” is also sometimes referred to herein as the “Existing Premises.” 

Commencing on the Expanded Premises Commencement Date and continuing thereafter for the duration of the Lease Term (as modified by Clause
(d) of this Section 2 below), approximately 53,347 square feet of space located in the Building, comprising the entire rentable space in the Building on such date (including, the Expansion Space as expanded by the Landlord’s Mezzanine
Work [it being 

  
 -2-

 
agreed however, that the square footage of such Mezzanine Expansion Improvements only will be subject to verification as set forth in Section 6.2 below]), and known collectively as Suite 100
and Suite 150. 
  

	 Expansion Space (Section 1.4) 
	The entire rentable space in the Building other than the rentable space that comprises the Existing Premises (as set forth in this Clause (a) above), comprising approximately 22,249 square
feet of rentable space (including the expansion of the existing mezzanine located within the Expansion Space by Landlord’s Mezzanine Work [it being agreed however, that the square footage of such Mezzanine Expansion Improvements only will be
subject to verification as set forth in Section 6.2 below]), and known as Suite 150 of the Building.” 

(b) Section 7 of the Original Summary is hereby modified as follows: 

 

	 “7. Project: 
	That certain 3-building office and research and development project commonly known as “The Campus” located and addressed at 5962, 5964 and 5966 La Place Court, Carlsbad, California,
respectively and comprising a total of approximately 166,747 rentable square feet (inclusive of the expansion of the existing mezzanine located within the Expansion Space by Landlord’s Mezzanine Work [it being agreed however, that the square
footage of such Mezzanine Expansion Improvements only will be subject to verification as set forth in Section 6.2 below]).” 

 (c) Section 8 of the Original Summary is hereby modified as follows: 
  

	 “8. Building 
	That certain office and research and development building located in the Project and addressed at 5964 La Place Court, Carlsbad, comprising a total of approximately 53,347 square feet of
rentable area (inclusive of the expansion of the existing mezzanine located within the Expansion Space by Landlord’s Mezzanine Work [it being agreed however, that the square footage of such Mezzanine Expansion Improvements only will be subject
to verification as set forth in Section 6.2 below])” 

 (d) Section 9 of the Original Summary is
hereby modified as follows: 
 “9. Term (Article 2). 

 

	 9.1 Lease Term: 
	Approximately ten (10) years and seven (7) months. 

  

	 9.2 Lease Commencement Date: 
	July 15, 2010 respecting the Existing Premises. 

  

	 9.3 Expanded Premises Commencement Date: 
	 The earlier of: (i) July 1, 2013 (which July 1, 2013 date may be accelerated by Tenant, in 

  
 -3-

	 	 
Tenant’s sole discretion, as set forth in Section 1.3.3(b) of the Expansion Space Work Letter attached hereto as Exhibit “B”), and (ii) the date that is the
earlier of: (a) the early termination of the Temporary Warehouse License (as defined in Section 11(b) of this Second Amendment), but only in the event that Landlord exercises its right of early termination as a result of a Tenant Use
Violation (subject to the terms and conditions of Section 11(c) of this Second Amendment); and (b) the date Tenant commences operations in all or any portion the Expansion Space following Substantial Completion of the Expansion Space
Tenant Improvements (as defined in Section 4.3 of the Expansion Space Work Letter). 

  

	 9.4 Lease Expiration Date: 
	The date immediately preceding the ninety-first (91st) monthly anniversary of the Expanded Premises Commencement Date; provided, however, that if the Expanded Premises Commencement Date is a date other than the first (1st) day of a month, then the Lease Expiration Date shall be the
last day of the month which is ninety-one (91) months after the month in which the Expanded Premises Commencement Date falls.” 

 (e) Section 10 of the Original Summary is hereby modified as follows: 

“10. Base Rent (Article 3). 
  

													
	 Months of Lease Term
	  	Annual Base Rent	 	 	Monthly
Installment of 
Base Rent	 	 	Monthly Rental
Rate 
per Square Foot	 
	 July 2010 – June 2011D
	  	$	541,105.20	* 	 	$	45,092.10	** 	 	$	1.45	* 
	 July 2011 – June 2012D
	  	$	556,032.24	‡† 	 	$	46,336.02	‡† 	 	$	1.49	‡† 
	 July 2012 – June 2013D
	  	$	574,691.04	*‡† 	 	$	47,890.92	*‡† 	 	$	1.54	*‡† 
	 July 2013 – June 2014
	  	$	1,011,450.10	  	 	$	84,288.26	  	 	$	1.58	  
	 July 2014 – June 2015
	  	$	1,043,467.30	  	 	$	86,955.61	  	 	$	1.63	  
	 July 2015 – June 2016
	  	$	1,075,475.50	  	 	$	89,622.96	  	 	$	1.68	  
	 July 2016 – June 2017
	  	$	1,107,483.70	  	 	$	92,290.31	  	 	$	1.73	  
	 July 2017 – June 2018
	  	$	1,139,491.90	  	 	$	94,957.66	  	 	$	1.78	  
	 July 2018 – June 2019
	  	$	1,171,500.10	  	 	$	97,625.01	  	 	$	1.83	  
	 July 2019 – June 2020
	  	$	1,209,909.90	  	 	$	100,825.83	  	 	$	1.89	  
	 July 2020 – Lease Expiration Date
	  	$	1,248,319.80	  	 	$	104,026.65	  	 	$	1.95	  

  

	D	Reflects the Base Rent attributable to the Existing Premises only. 

	*	Subject to abatement as set forth in Section 3.2 of the Original Lease with respect to the Existing Premises only. 

	‡	Does not include Tenant’s obligation to pay the Monthly Warehouse License Fee payable for the period beginning November 1, 2011 and expiring on the Warehouse
Expiration Date, as set forth in Section 11(b) of this Second Amendment. 

	†	 If the Expanded Premises Commencement Date falls on any date prior to July 1, 2013 (including, without limitation as a result of Tenant’s
election to accelerate such July 1, 2013 date pursuant to Section 1.3.1 of the Expansion Space Work Letter), then the Monthly Installment of Base Rent payable by Tenant as set forth in this Clause (e) of this Section 2 above
shall increase by an amount equal to 22,249 × the applicable Monthly Rental Rate (subject to proration in accordance with Section 3.1 of the Original Lease if the Expanded Premises Commencement Date is not the first (1st) day of a calendar month.” 

  
 -4-

 (f) Section 11 of the Original Summary is hereby modified as follows: 

“11. Additional Rent (Article 4). 
  

			
	11.1 Tenant’s Share of Project Direct Expenses (prior to the Expanded Premises Commencement Date):	  	18.65%.
		
	Tenant’s Share of Project Direct Expenses (commencing on the Expanded Premises Commencement Date):	  	Approximately 31.99%.
		
	11.2 Tenant’s Share of Building Direct Expenses (prior to the Expanded Premises Commencement Date):	  	58.29%.
		
	Tenant’s Share of Building Direct Expenses (commencing on the Expanded Premises Commencement Date):	  	100%.”

 (g) Section 12 of the Original Summary is hereby modified as follows: 

“12. Cash Security Deposit (Section 21.1). 
  

			
	Prior to Effective Date of this Second Amendment:	  	$55,354.44.
		
	 As of the Effective Date of this Second Amendment:
	  	$77,320.10
		
	 As of the L/C Increase Date (as defined in Section 12 of this Second Amendment):
	  	$104,026.65
		
	Letter of Credit Stated Amount (Section 21.2).	  	
		
	Initial Stated Amount:	  	$500,000.00
		
	Increased Stated Amount (per Section 12 of this Second Amendment):	  	$857,819.76”

 (h) Section 13 of the Original Summary is hereby modified as follows: 

“13. Parking Pass Ratio (Article 28). 
  

	 13.1 Tenant’s Parking Pass Ratio (prior to the Expanded Premises Commencement Date): 
	Prior to the Expanded Premises Commencement Date, Tenant shall have the right to utilize up a total of one hundred eight (108) unreserved and non-exclusive parking passes (it being agreed
that the Parking Area includes handicapped and visitor spaces as same may be designated from time to time by Landlord and which number of unreserved and non-exclusive parking passes reflects those Equipment Area Spaces that are encumbered by
Tenant’s Common Area Equipment as of the Effective Date of the Second Amendment (which Landlord and Tenant agree is approximately sixteen (16) parking spaces)). 

  
 -5-

	 13.2 Tenant’s Parking Pass Ratio (commencing on Expanded Premises Commencement Date): 
	Commencing on the Expanded Premises Commencement Date, Tenant’s unreserved and non-exclusive parking passes shall increase to a total of one hundred ninety-two (192) unreserved and
non-exclusive parking passes; provided, however, that in the event that any of Tenant’s Common Area Equipment is removed from the Equipment Area Spaces during the Lease Term, Tenant’s allocation of unreserved and non-exclusive parking
passes shall be increased by the number of Equipment Area Spaces that are no longer actually so encumbered, thus resulting in an increase of Tenant’s total Project parking passes up to a maximum of two hundred eight (208) unreserved and
non-exclusive parking passes. 

  

	 13.3 Short Term Spaces (Article 28): 
	Tenant shall have the right to designate a portion of its parking rights in the Project as included in the Parking Pass Ratio as “GenMark Reserved” pursuant to the terms and conditions
of Article 28 of the Original Lease (as previously modified by the Section 4 of the First Amendment) relating to the same, except that: (a) prior to the Expansion Premises Commencement Date Landlord agrees to designate a total of four
(4) Short Term Spaces; and (b) at any time following removal of Tenant’s Common Area Equipment from some or all of the Equipment Area Spaces, for each of the Equipment Area Spaces so unencumbered, Tenant may designate one
(1) additional Short Term Space, up to a maximum of a total of seven (7) Short Term Spaces.” 

 (i)
Section 15 of the Original Summary is hereby modified as follows: 
 “15. Tenant Improvement Allowance. 

(Section 3.1 of Exhibit “C” to Original Lease (with respect to the Initial Improvements constructed pursuant to
the terms and conditions of the Original Lease, as previously modified by the First Amendment only); and Section 3.1 of Exhibit “B” to this Second Amendment [with respect to the Expansion Space Improvements to be
constructed pursuant to the terms and conditions of this Second Amendment only]) 
  

	 15.1 Initial Tenant Improvements: 
	Up to One Million Eight Hundred Ninety-Eight Thousand Eight Hundred Forty-Three and 80/100 Dollars ($1,898,843.80) (calculated based upon $61.06 per square foot within the Existing Premises
only), subject to the terms and conditions of Section 3.1 of the Tenant Work Letter attached to the Original Lease as Exhibit “C”. 

 

	 15.2 Expansion Space Tenant Improvements: 
	 Up to One Million Three Hundred Fifty Eight Thousand Five Hundred Twenty-Three and 94/100 Dollars ($1,358,523.94) (calculated based upon $61.06 per square foot within the Expansion Space as
of the Expanded Premises Commencement Date), subject to the terms and conditions of Section 3.1 of the Expansion 

  
 -6-

	 	 
Space Work Letter attached as Exhibit “B” to this Second Amendment.” 

 3. Tenant Improvements. The defined term “Tenant Improvements” as used in the Original Lease and the First Amendment and relating to the Existing Premises only (including all references
to such Tenant Improvements as the “initial Tenant Improvements”) is hereby changed to “Initial Tenant Improvements.” However, for the purposes of the design, construction and funding of Tenant’s initial alterations
and improvements to the Expansion Space (which are hereinafter referred to as the “Expansion Space Tenant Improvements,” and in the Expansion Space Work Letter as the “Tenant Improvements”), Exhibit
“C” to the Original Lease is hereby superseded and replaced by the Expansion Space Work Letter it being agreed that the language within the Expansion Space Work Letter refers to the Expansion Space Work Letter as the
“Tenant Work Letter”. 
 4. Tenant’s Current Possession of the Existing Premises. Landlord and
Tenant hereby agree that pursuant to the Original Lease (as previously amended by the First Amendment), (a) Landlord currently leases to Tenant and Tenant currently leases from Landlord the Existing Premises, (b) the Existing Premises
comprises 31,098 square feet of space in the Building, in accordance with the Landlord’s drip-line method of measurement of the Building (to the exterior walls of the Building without exclusions for any soffits or penetrations, the
“Drip-Line Method”) and is not subject to re-measurement, (c) Tenant has accepted possession of the Existing Premises demised under the Original Lease (as previously amended by the First Amendment), and (d) all items of an
executory nature with respect to the Existing Premises, that were required by the terms and conditions of the Original Lease (as previously amended by the First Amendment) to have been completed by either party prior to the Effective Date of this
Second Amendment, have been completed under the terms of the Original Lease (as previously amended by the First Amendment), including, but not limited to, completion of construction of the Initial Tenant Improvements, Landlord’s payment of the
Tenant Improvement Allowance relating to the Initial Tenant Improvements, and tenant’s payment of any Excess Costs of the cost of the Initial Tenant Improvements. 
 5. Addition of Expansion Space. Landlord and Tenant hereby agree that, as of the Expanded Premises Commencement Date: (a) Landlord shall lease to Tenant, and Tenant shall lease from Landlord,
the Expansion Space, as described in Section 6 of the Original Summary (as modified by Clause (a) of Section 2 of this Second Amendment) pursuant to the terms and conditions of the Lease as modified by this Second Amendment;
(b) all of Tenant’s leasehold interest in the Premises pursuant to the Lease shall include the Expansion Space as incorporated therein (and all references to the “Premises” shall thereafter mean the Premises incorporating
the Expansion Space); (c) Tenant shall be deemed to have exercised its option to expand as set forth in Section 1.4 of the Original Lease, with the terms and conditions of Tenant’s leasing of the Expansion Space pursuant thereto
modified to reflect the terms and conditions set forth in this Second Amendment (and in the event of any conflict between the terms and conditions of Section 1.4 of the Original Lease and this Second Amendment, this Second Amendment shall
control); and (d) the Premises incorporating the Expansion Space shall comprise approximately 53,347 square feet of space in accordance with Landlord’s Drip-Line Method and will be subject to re-measurement only to the extent set forth in
Section 6.2 below with respect to Landlord’s obligation to verify the square footage of the Mezzanine Expansion Improvements only. 
 6. Landlord’s Mezzanine Work. Landlord shall, at Landlord’s sole cost and expense, in accordance with the approved T.I. Pans and Specifications (as defined in Section 1.3.8 of the
Expansion Space Work Letter), cause the construction of structural improvements in the Expansion Space as required for the addition of approximately 2,513 square feet of additional mezzanine space (the “Mezzanine Expansion
Improvements”). The Mezzanine Expansion Improvements shall be contiguous and level with, and otherwise generally similar to, the structural components of the existing mezzanine space improvements that are currently, as of the Effective
Date, located in the Expansion Space (the “Existing Mezzanine Improvements”), and in the approximate configuration depicted on Exhibit “A” to this Second Amendment. Landlord shall contract with
Landlord’s Contractor (as defined in Section 3.3.3 of the Expansion Space Work Letter) to construct the Mezzanine Expansion Improvements (as a bid alternate), for a period of construction to occur concurrent with the construction of the
Expansion Space Tenant Improvements, and shall cause the Mezzanine Expansion Improvements to be completed in a good and workmanlike manner so as not to delay the construction of the Expansion Space Tenant Improvements beyond July 1, 2013 (or
such earlier date as may be applicable if Tenant 

  
 -7-

 
timely delivers Tenant’s Ready to Commence Construction Notice) (collectively, the “Landlord’s Mezzanine Work”). 

6.1 Structural Work. Landlord shall be solely responsible for any damage to the roof, foundation or walls of the Building caused
by, or attributable to, the Landlord’s Mezzanine Work, or as a result of any damage caused by structural alterations to the Building required for the installation the related Skylights and Stairs (as defined in Section 1.3.3 of the
Expansion Space Work Letter); and the costs of any such repairs shall not be included the Building Direct Expenses. 
 6.2
As-Built Verification of Additional Mezzanine Space. Within thirty (30) days after Substantial Completion of the Expansion Space Tenant Improvements or as soon as reasonably practicable thereafter (but in any event within ninety
(90) days after Substantial Completion of the Expansion Space Tenant Improvements), Landlord shall cause Landlord’s Architect to verify that the floor area added to the Building by the Mezzanine Expansion Improvements is approximately
2,513 square feet of additional space (in accordance with the Drip-Line Method), and Tenant shall receive a copy of such verification of the Premises floor area for the completed the Landlord’s Mezzanine Work. If the Landlord’s Mezzanine
floor area calculations of Landlord’s architect for the mezzanine expansion indicates that the area of the mezzanine expansion is less than 2,250 square feet or more than 2,750 square feet (a “Material Space Deviation”), then
the square footage of the Expansion Space shall be reduced or increased, as the case may be, to reflect the actual square footage of the additional mezzanine space added to the Expansion Space by the Landlord’s Mezzanine Work; provided that in
no event shall Tenant pay rent on more than 53,584 square feet of Premises in the Building as a result of any Material Space Deviation. Except as provided in the previous sentence with respect to a Material Space Deviation, Landlord and Tenant agree
that the square footage of (a) the Expansion Space (as set forth in the second paragraph of Section 6 of the Original Summary, as modified in Clause (a) of Section 2 of this Second Amendment), (b) the Project (as set forth
in the second paragraph of Section 7 of the Original Summary, as modified in Clause (b) of Section 2 of this Second Amendment) and (c) Building (as set forth in Section 8 of the Original Summary, as modified in Clause
(c) of Section 2 of this Second Amendment) are approximate and good faith estimates of such area, and unless the verification of floor area by Landlord’s architect or space planner for the mezzanine expansion as set forth in and
subject to this Section 6.2 indicates a Material Space Deviation in the estimated square footage of the additional mezzanine space actually constructed by Landlord as part of the Landlord’s Mezzanine Work, the terms and conditions of
Section 1.3 of the Original Lease shall apply to the Premises as expanded to incorporate the Expansion Space (including the expansion of the existing mezzanine located within the Expansion Space by the Landlord’s Mezzanine Work). In the
event that it is ultimately determined that the square footage amount of the Expansion Space and Building has been modified as a result of a Material Space Deviation, then all amounts, percentages and figures appearing or referred to in this Second
Amendment based upon the incorrect rentable square footage amount (including, without limitation, the amount of the Tenant Improvement Allowance attributable to the Expansion Space Tenant Improvements (as set forth in the Expansion Space Work
Letter), the Monthly Base Rent and the Tenant’s Share of Project Direct Expenses) shall be retroactively modified as of the Expanded Premises Commencement Date as provided in this Section 6.2, in accordance with such determination, and any
prior overpayments and/or underpayments of any such amounts based on the incorrect rentable square footage amount by Tenant and/or Landlord shall be reconciled with appropriate payments by the appropriate party hereto being made within thirty
(30) days after the date of determination. If such determination is made, it will be confirmed in writing by Landlord to Tenant. 
 7. Extended Term of the Lease. The Lease Term for Tenant’s lease of the entire Premises (i.e., the Existing Premises as expanded by the Expansion Space), including that portion of the
Lease Term following the Expanded Premises Commencement Date is hereby extended to expire on the Lease Expiration Date (as the definition thereof in Section 9 of the Original Summary is modified by Clause (d) of Section 2 above).
Tenant’s option to further extend the Lease Term pursuant to Section 2.2 of the Original Lease shall be limited to the entire Premises (i.e., the Existing Premises as expanded by the Expansion Space), and may not be exercised by
Tenant with respect to the Existing Premises only or the Expansion Space only. 
 8. Base Rent. Commencing as of the
Expanded Premises Commencement Date and continuing throughout the Lease Term as extended pursuant to modified definition of Lease Expiration Date set forth in Section 9.4 of the Original Summary, as modified in Clause (d) of

  
 -8-

 
Section 2 of this Second Amendment, Tenant shall pay, in accordance with the provisions of this Section 8, Base Rent for the entire Premises (i.e., the Existing Premises as
expanded by the Expansion Space) as follows: (a) if the Expanded Premises Commencement Date occurs prior to July 1, 2013, then Tenant shall pay to Landlord the monthly installments of Base Rent attributable to the Expansion Space at the
same Monthly Rental Rate per square foot as is payable under the Lease for the Existing Premises, at the applicable rate set forth in Section 10 of the Original Summary (as modified by Clause (e) of Section 2 above), which shall be
added to the monthly installment of Base Rent otherwise payable by Tenant pursuant to Section 10 of the Original Summary (as modified by Clause (e) of Section 2 above) for the Existing Premises only as the aggregate monthly
installment of Base Rent payable for the entire Premises (i.e., the Existing Premises as expanded by the Expansion Space) from the Expanded Premises Commencement Date until June 30, 2013 (with any partial month of Base Rent for the
expansion Space for the calendar month in which the Expanded Premises Commencement Date occurs to be prorated, if at all, in accordance with Section 3.1 of the Original Lease ); and (b) commencing on July 1, 2013, and continuing
thereafter until the Lease Expiration Date set forth in Clause (d) of Section 2 above, Tenant shall pay the monthly installments of Base Rent in the amounts set forth in Section 10 of the Original Summary as modified by Clause
(e) of Section 2 of this Second Amendment. Tenant’s abatement of Base Rent for months 29 and 30 of the initial Lease Term of the Lease (as set forth in Section 9 of the Original Summary and without regard to this Second
Amendment) shall apply to Base Rent payable for the Existing Premises only during such months, regardless of whether the Expanded Premises Commencement Date occurs prior to the 29th month of the Lease Term (as set forth in Section 9 of the Original Summary and without regard to this Second
Amendment). Landlord and tenant hereby agree that the rent abatement contained in Section 3.2 of the Original Lease shall not apply to the Expansion Space, and that the amortization of abated rent shall not be modified by the extension of the
Lease Term pursuant to this Second Amendment. 
 9. Tenant’s Share of Direct Expenses/Management Fee.
Notwithstanding anything to the contrary in the Lease, effective as of the Expanded Premises Commencement Date and continuing thereafter throughout the Lease Term as extended by this Second Amendment, Tenant’s Share of Direct Expenses for the
Building (i.e., the Existing Premises as expanded by the Expansion Space) shall be one hundred percent (100%); and Tenant’s Share of Direct Expenses for the Project shall be equal to the percentage of the square footage of the Project
that is located in the Building, which is approximately thirty one and 99/100ths percent (31.99%). In addition, notwithstanding anything to the contrary contained in clause (vi) of Section 4.2.5 of the Original Lease effective as of
January 1, 2012 Landlord’s management fee for the Project will be four percent (4%) of gross receipts for the Project (i.e., Annual Base Rent and items of regularly recurring Additional Rent) per year instead of four percent
(4%) of all receipts for Annual Base Rent for the Project per year. 
 10. Expansion Space Tenant Improvements. The
Expansion Space Tenant Improvements shall be renovated and/or installed and constructed in accordance with the terms of the Expansion Space Tenant Work Letter. 
 11. Use of Expansion Space as Temporary Warehouse Space. Tenant and Landlord hereby agree that during that portion of the Lease Term preceding the commencement of the New Warehouse License Period
(as defined in Section 11(b) below), and commencing on July 15, 2010 (the “Prior Warehouse License Commencement Date”), Tenant occupied portions of the Expansion Space for purposes of storage and warehousing certain
personal property and inventory (the “Expired Temporary Warehouse License”), without a written agreement with Landlord for such leasing or occupancy thereof. Landlord and Tenant wish to resolve the Warehouse Claims relating to
Tenant’s use of the Expansion Space during the Expired Warehouse License Period as follows: 
 (a)
Conditional Waiver of Liquidated Claims for Prior Use. In consideration for Landlord’s agreement to fully and finally settle and release any and all claims that Landlord may have arising out of the Warehouse Claims (exclusive of the
Surviving Matters), (i) Tenant and Landlord have agreed that Tenant is obligated to pay to Landlord a lump sum payment in the amount of $258,524.50 (the “Liquidated Warehouse License Fee”), which is calculated based upon a flat
monthly license fee rate of $16,679.00/month for the 15 1/2-month period during the term of the Expired Temporary Warehouse License; provided, however, that (x) as part of the Parties’ mutual settlement of their respective claims incorporated into the
Second Amendment Disputes (exclusive of the Surviving Matters), and (y) as a portion of the consideration for 

  
 -9-

 
Tenant’s agreement to (1) license the Expansion Space during the term of the New Temporary Warehouse License (as defined in Section 11(b) below), and (2) lease the Expansion
Space (as expanded by the Mezzanine Expansion Improvements) as part of the Premises for the extended Lease Term pursuant to this Second Amendment, and (z) provided that Tenant is not in material or monetary default under the Lease (as amended
hereby) prior to the Expanded Premises Commencement Date (unless such default is timely cured by Tenant, following Tenant’s receipt of notice of such default, prior to the expiration of the cure period associated with such default), then
Landlord agrees that the Liquidated Warehouse License Fee is fully satisfied and forever released effective as of the Expanded Premises Commencement Date, and (ii) the Parties hereby agree that notwithstanding the releases provided herein,
Tenant’s occupancy of the Expansion Space during the term of the Expired Warehouse License shall remain subject to all of the Surviving Matters, notwithstanding the waiver and release of the Liquidated Warehouse License Fee as of the Expanded
Premises Commencement Date, which shall extend back, as obligations of Tenant arising out of the Original Lease (and without regard to any releases contained in the First Amendment), to July 15, 2010. In the event of a default by Tenant under
the terms of the Lease (as amended hereby) that results in the early termination of the Lease, pursuant to the provisions of Section 19.2 of the Original Lease, prior to the Expanded Premises Commencement Date, the Liquidated Warehouse License
Fee shall become immediately due and payable as part of Landlord’s damages arising out of the exercise of Landlord’s right to terminate the Lease. 

(b) New Warehouse License. Landlord has agreed to license to Tenant, and Tenant has agreed to license from
Landlord, the entirety of the Expansion Space, on a temporary basis, for the Warehouse License Permitted Uses (as hereinafter defined) only (the “New Temporary Warehouse License”), during that period (the “New Warehouse
License Period”) that commenced on November 1, 2011 (the “New Warehouse License Commencement Date”), and continuing thereafter until that date (the “Warehouse Expiration Date”) which is the earliest
of: (i) January 31, 2013; (ii) thirty (30) days after Tenant’s approval of the T.I. Construction Drawings, as set forth in Section 1.3.7 of the Expansion Space Work Letter, in the event Tenant timely and promptly
delivers Tenant’s Ready to Commence Construction Notice; and (iii) the date of earlier termination of the New Temporary Warehouse License pursuant to Tenant’s breach of the limitations on its use of the Expansion Space to the
Warehouse License Permitted Uses during the New Warehouse License Period, as described in Section 11(c) below. Tenant’s use of the Expansion Space during the New Warehouse License Period is limited to warehousing and storage of its
personal property therein, and for no other use or purpose whatsoever, it being agreed by the Parties that in no event shall Tenant conduct any other business operations (including, without limitation, general office or research and development
and/or laboratory uses) in any portion of the Expansion Space prior to the Expanded Premises Commencement Date (the “Warehouse License Permitted Uses”); provided, however, that Landlord’s staging of materials and equipment in
preparation for the construction of the Expansion Space Tenant Improvements, if authorized by Tenant (which authorization shall not be unreasonably withheld, conditioned or delayed) to occur during the New Warehouse License Period shall be
considered part of the Warehouse License Permitted Uses. In connection with Tenant’s Temporary Warehouse License during the New Warehouse License Period, Tenant shall pay to Landlord, a monthly license fee (the “New Warehouse License
Monthly Fee”) equal to $16,679.00/month. Such New Warehouse License Monthly Fee shall be payable on the first
(1st) day of each month in advance during the New
Warehouse License Period at the same time and in the same manner as monthly Base Rent for the Premises; provided that the New Warehouse Monthly Fee for the period between the New Warehouse License Commencement Date and the last day of the calendar
month in which the Effective Date of this Second Amendment occurs shall be due and payable concurrent with Tenant’s execution and delivery of this Second Amendment to Landlord. In the event that the New Warehouse License Monthly Fee is not paid
when due following the Effective date of this Second Amendment, then such failure shall be considered a monetary default under the Lease, and if such monetary default is not timely cured by Tenant, Landlord shall have the same rights as provided in
Article 19 of the Original Lease for any other monetary default under the Lease. The New Warehouse License Monthly Fee shall be deemed to include Tenant’s Share of all Direct Expenses of the Building and the Project associated with the
Expansion Space only, provided that Tenant shall at all times during the New Warehouse License Period directly pay (or reimburse Landlord for) all electricity separately metered or sub-metered to the Expansion Space (and if such amounts have been
previously paid by Landlord, or are billed to and paid by Landlord following the Effective date of this Second 

  
 -10-

 
Amendment, Tenant shall reimburse Landlord for such electricity bills paid by Landlord within 30 days of receiving a copy of the paid electricity bill from Landlord). 

(c) Warehouse License Permitted Use Violation. Notwithstanding the foregoing or anything to the contrary
contained in this Second Amendment, Landlord shall have the right to enter the Expansion Space at any time during the New Warehouse License Period, without prior notice, to verify that Tenant is not occupying or otherwise using any portion of the
Expansion Space for any use or operations other than the Warehouse License Permitted Uses. If, at anytime during the New Warehouse License Period, Tenant occupies or otherwise uses any portion of the Expansion Space for any use or operations other
than the Warehouse License Permitted Uses and Landlord notifies Tenant in writing (the “Use Violation Notice”) of such violation, and unless Tenant terminates such unauthorized use or operations within five (5) business days
following Tenant’s receipt of the Use Violation Notice, then Tenant’s New Temporary Warehouse License shall expire on that date which is five (5) business days after Tenant’s receipt of the Use Violation Notice (and further
provided that following Tenant’s receipt of a second (2nd) Use Violation Notice from Landlord during the New Warehouse License Period, which sets forth a factually accurate violation of the Warehouse License Permitted Uses, Tenant shall have no right to
cure such second (2nd) event of unauthorized use and
the New Temporary Warehouse License shall terminate as of that date which is five (5) business days after Tenant’s receipt of the applicable Use Violation Notice). In the event that the New Temporary Warehouse License is terminated
pursuant to any Use Violation Notice received by Tenant during the New Warehouse License Period, the Expanded Premises Commencement Date shall be deemed to have automatically occurred as set forth in Section 9.3 of the Original Summary, as
modified by Clause (d) of Section 2 above. 
 (d) Tenant’s license of the Expansion Space pursuant to the New
Temporary Warehouse License shall be subject to all of the terms, conditions and limitations set forth in the Lease, as amended hereby, regarding the Existing Premises except as follows: 

 

	 	i.	Tenant agrees that Tenant currently licenses and will continue to license the Expansion Space in its current “as-is” condition; 

 

	 	ii.	Tenant shall not be liable for any Direct Expenses attributable to the square footage of the Expansion Space prior to the Expanded Premises Commencement Date;

  

	 	iii.	The construction of the Expansion Space Tenant Improvements shall be subject to the terms and conditions of Tenant Work Letter attached to this Second Amendment, and
the terms and conditions of Article 8 of the Lease shall be applicable to the Expansion Space only with respect to any alterations made by or for Tenant to the existing improvements in the Expansion Space (as of the Effective Date), which are not
included in the Landlord’s Work; and 

  

	 	iv.	Upon the expiration of the New Temporary Warehouse License, the Expansion Space shall be incorporated into the Premises in accordance with the terms and conditions of
the Lease as modified by this Second Amendment (and the terms of this Section 11 governing the use of the Expansion Space pursuant to the New Temporary Warehouse License shall be superseded by the terms and condition of Tenant’s leasing of
the Expansion Space as part of the Premises). 

 12. Letter of Credit. On or before the date (the
“L/C Increase Date”) that is the earlier of (a) thirty (30) days after Landlord’s approval or deemed approval of the T.I. Construction Drawings, if Tenant delivers Tenant’s Ready to Commence Construction Notice,
and (b) January 1, 2013, Tenant shall cause the amount of security for Tenant’s Lease obligations held by Landlord in the form of a Letter of Credit to be increased to the Increased Stated Amount (as defined in Section 12 of the
Original Summary, as modified by Clause (g) of Section 2 above); provided, however, that if the Initial Stated Amount is reduced pursuant to the terms and conditions of Section 21.2 of the Original Lease on any Adjustment Date
occurring prior to the L/C Increase Date, then the Increased Stated Amount shall be reduced as hereinafter provided. In order to satisfy the requirement to increase the amount of the Letter(s) of Credit to the Increased Stated Amount (as the same
may be adjusted on any Adjustment Date occurring prior 

  
 -11-

 
to the L/C Increase Date), Tenant shall have the right to elect to either: (i) increase the Initial Stated Amount of its existing Letter of Credit or (ii) cause a new Letter of Credit
to be issued in the Increased Stated Amount (as reduced to reflect any Adjustment Date reduction as hereinafter provided), which new Letter of Credit shall be subject to all the terms and conditions applicable to Tenant’s existing Letter of
Credit, as set forth in Article 21 of the Original Lease. The schedule of Adjustment Dates set forth in Section 21.2 of the Original Lease is hereby amended as follows with respect to the Increased Stated Amount required by this Second
Amendment: 
  

					
	 Adjustment Date
	  	Increased
Stated
Amount	 
		
	 The second (2nd) anniversary of the Lease Commencement Date
	  	$	686,255.81	  
		
	 The third (3rd) anniversary of the Lease Commencement Date
	  	$	514,691.86	  
		
	 The fourth (4th) anniversary of the Lease Commencement Date
	  	$	343,127.90	  
		
	 The fifth (5th) anniversary of the Lease Commencement Date
	  	$	171,563.95	  
		
	 The sixth (6th) anniversary of the Lease Commencement Date
	  	$	0.00	  

 13. Increased Security Deposit. As an additional inducement for Landlord entering into this Second
Amendment, Tenant shall deposit with Landlord, in immediately available funds, the following amounts on the following dates: (a) concurrent with delivery of the Tenant-executed originals of this Second Amendment to Landlord, the amount required
to increase the Security Deposit held by Landlord under the Original Lease to the amount (i.e., $77,320.10) required following the Effective Date of this Second Amendment as set forth in Section 12 of the Original Summary as modified in
Clause (g) of Section 2 above, (i.e., $21,965.66 – the “Initial Additional Security Deposit Amount”); and (b) on or before the L/C Increase Date, the amount required to increase the Security Deposit held
by Landlord following the Effective Date of this Second Amendment to the amount (i.e. $104,026.65) required to be deposited with Landlord following the L/C Increase Date as set forth in Section 12 of the Original Summary as modified in
Clause (g) of Section 2 above, (i.e., $26,706.55– the “Second Additional Security Deposit Amount”). Tenant’s failure to timely deliver either the Initial Additional Cash Security Deposit or the Second
Additional Cash Security Deposit as required pursuant to this Section 13 shall constitute an event of monetary default under the Lease (as amended hereby). The initial Security Deposit, as increased by the Landlord shall continue to hold the
Security Deposit as increased by the Initial Additional Cash Security Deposit and the Second Additional Cash Security Deposit, shall be hereinafter referred to in the Lease as the “Security Deposit”. 

14. Other Modifications. Section 14 of the Original Summary and Section 29.24 of the Original Lease are hereby excluded
from this Second Amendment and all transactions contemplated hereby; Section 1.5 of the Original Lease is hereby deleted in its entirety and shall be of no further force or effect; and the last sentence of Section 29.5 is hereby modified
as follows: 
 “Notwithstanding the foregoing, if the Landlord originally named in this Lease (the
“Original Landlord”) assigns or otherwise transfers its fee interest in the Building prior to (a) substantial completion of the Expansion Space Tenant Improvements to be completed by Landlord pursuant to the Second Amendment to
this Lease and (b) the distribution of the entire remaining balance of the Expansion Space Tenant Improvement Allowance (if any) required to be distributed by Landlord pursuant to the terms and conditions of the Expansion Space Work Letter for
the Expansion Space Tenant Improvements, attached as Exhibit “B” to the Second Amendment to this Lease, and except to the extent that it has been finally adjudicated (by any judicial decision, binding arbitration,
settlement agreement or otherwise), that such 

  
 -12-

 
Expansion Space Tenant Improvement Allowance (or portion thereof) is not due and payable by Original Landlord (collectively, the obligations referred to in clauses (a) and (b) above are
referred to in this Section 29.5 as the “Original LL Requirements”) and further provided that the transferee of Original Landlord’s fee interest in the Project does not expressly assume Original Landlord’s obligations
respecting the Original LL Requirements in writing, then Original Landlord shall within ten (10) business days following such assignment or transfer put into a third party escrow account designated by Original Landlord (which escrow shall be
jointly paid for by Landlord and Tenant) for distribution to the Contractor (as defined in the Expansion Space Work Letter) on a progress payment basis pursuant to Tenant’s standard disbursement procedure for the Expansion Space Tenant
Improvements and upon receipt of the appropriate conditional and/or unconditional lien releases, an amount equal to the balance of any unpaid portion of the Expansion Space Tenant Improvement Allowance for the Expansion Space Tenant
Improvements.” 
 15. Notice of Lease Term Dates. Landlord will deliver to Tenant a written notice in a form similar
to Exhibit “D” to the Original Lease, confirming the Expanded Premises Commencement Date. Tenant agrees to execute and return to Landlord said commencement letter accurately setting forth the Expanded Premises
Commencement Date within ten (10) business days after Tenant’s receipt thereof. 
 16. Brokers. Each party
represents and warrants to the other that other than Cassidy Turley representing Landlord (“Landlord’s Broker”) and Hughes Marino representing Tenant (“Tenant’s Broker”), no other broker, agent or finder
negotiated or was instrumental in negotiating or consummating this Second Amendment. Landlord shall pay Landlord’s Broker and Tenant shall pay Tenant’s Broker pursuant to the terms of separate written agreements with respect to each such
party; provided, however, that Landlord and Tenant both agree to reasonably cooperate with one another in seeking a reduction of the amounts claimed by Tenant’s Broker as the commission due and payable by Landlord for its representation of
Tenant with respect to this Second Amendment, and Landlord agrees to reimburse Tenant an amount equal to fifty percent (50%) of the total commission paid by Tenant to Tenant’s Broker pursuant to this Section 16, subject to the
Parties’ good faith and reasonable agreement on such amount in advance, which amount will be paid by Landlord to Tenant within thirty (30) days after Landlord’s receipt of Tenant’s written request therefor (which request must be
accompanied by evidence of payment and a written acknowledgement from Tenant’s Broker that the commission payable to Tenant’s Broker in connection with this Second Amendment and the transactions contemplated herein have been paid in full).

 17. Representation of Tenant; Representation of Landlord. Tenant represents and warrants to Landlord that:
(a) Tenant is properly formed and validly existing under the laws of the state in which Tenant is formed and Tenant is authorized to transact business in the state in which the Building is located; and (b) each person (and both persons if
more than one signs) signing this Second Amendment on behalf of Tenant is duly and validly authorized to do so. Landlord hereby represents and warrants to Tenant that: (i) Landlord has received or will receive (prior to Landlord’s delivery
of the fully-executed originals of this Second Amendment to Tenant) any required consent of its existing lender, as required by the Subordination, Non-Disturbance and Attornment Agreement dated as of February 5, 2010 and recorded on
February 11, 2010 as Document No. 2010-0070838 in the Official Records of the San Diego County Recorder’s Office (the “SNDA”); and (ii) each person (and both persons if more than one signs) signing this Second
Amendment on behalf of Landlord is duly and validly authorized to do so. 
 18. Release and Surviving Matters.

 a. Mutual Release. As additional material consideration for Landlord’s and Tenant’s mutual agreement to enter
into this Second Amendment, and except for the rights, duties and obligation created by this Second Amendment, and conditioned on the performance by the Parties of their respective obligations under the provisions of the Lease as modified by this
Second Amendment, Tenant and Landlord agree to hereby fully and forever releases and discharges one another (and all of their respective affiliates, predecessors, successors and agents) 

  
 -13-

 
from any and all causes of action, changes, losses, damages, claims, demands, obligations and liabilities whatsoever in law or in equity that either Tenant or Landlord has or ever had as of the
date of this Second Amendment against the other Party, whether known or unknown, including, without limitation the Second Amendment Disputes, excluding, however, the Surviving Matters (as defined below), which are expressly reserved by Landlord as
liabilities of the Tenant for the remainder of the extended Lease Term, and for any period following the expiration or earlier termination of the Lease that such Surviving Matters may survive the Lease as expressly provided therein, and except for
the Surviving Matters, Landlord and Tenant mutually covenant and agree that all actual and alleged defaults relating thereto are hereby cured and deemed null and void for purposes of referencing any prior defaults in the Lease. With respect to the
matters released in this Section 18, Landlord and Tenant each expressly waives all rights under the provisions of California Civil Code Section 1542, which provides: “A general release does not extend to claims which the creditor
does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor.”  

Landlord and Tenant hereby acknowledge that each of them has respectively received the advice of legal counsel with respect to the
aforementioned release and waiver and understands the terms thereof. 
 b. Surviving Matters. The term “Surviving
Matters” shall mean and refer only to the following matters (all of which shall, notwithstanding anything to the contrary in this Second Amendment, be deemed to expressly survive the mutual release set forth in Section 18.1 above):
(i) the covenants and obligations of (A) Section 10.1 of the Original Lease, but only to the extent of the covenants and obligations to indemnify, defend and hold harmless Landlord and its employees and agents from and against any
claims for bodily or personal injury or property damage that occurred with respect to Tenant’s use of the Expansion Space prior to the New Warehouse License Commencement Date (subject, however, to the exceptions set forth in said
Section 10.1), including Tenant’s obligation to maintain insurance coverage with respect to such claims pursuant to Section 10.3.1 of the Original Lease, and (B) Section 5.3 of the Original Lease relating to Tenant’s
prior use of the Expansion Space; (ii) the covenants and obligations of Section 24.1 of the Original Lease, relating to Tenant’s violation of any Laws in its prior use and occupancy of the expansion Space; and (iii) any other
rights, obligations, liabilities, covenants, representations and/or warranties expressly created or reserved in this Second Amendment with respect to the Expansion Space. 
 19. Counterparts and Fax/Email/Electronic Signatures. This Second Amendment may be executed in counterparts, each of which shall be deemed an original, but such counterparts, when taken together,
shall constitute one agreement. This Second Amendment may be executed by a party’s signature transmitted by facsimile (“fax”) or email or by a party’s electronic signature, and copies of this Second Amendment executed and
delivered by means of faxed or emailed copies of signatures or originals of this Second Amendment executed by electronic signature shall have the same force and effect as copies hereof executed and delivered with original wet signatures. All parties
hereto may rely upon faxed, emailed or electronic signatures as if such signatures were original wet signatures. Any party executing and delivering this Second Amendment by fax or email shall promptly thereafter deliver a counterpart signature page
of this Second Amendment containing said party’s original signature. All parties hereto agree that a faxed or emailed signature page or an electronic signature may be introduced into evidence in any proceeding arising out of or related to this
Second Amendment as if it were an original wet signature page. 
 20. No Further Modification. Except as set forth in
this Second Amendment, all of the terms and provisions of the Lease shall continue to apply and shall remain unmodified and in full force and effect. Effective as of the date hereof, all references to the “Lease” shall refer to the Lease
as amended by this Second Amendment. 
 [SIGNATURES ATTACHED HERETO] 

  
 -14-

 IN WITNESS WHEREOF, this Second Amendment has been executed as of the day and year first
above written. 
  

							
	“Landlord”:
	
	THE CAMPUS CARLSBAD, LLC,
a Delaware limited liability company
		
	By:	 	NEWPORT NATIONAL / THE CAMPUS
CARLSBAD, LLC, a California limited liability
	Its:	 	Managing Member
			
		 	By:	 	Newport National Corporation,
a California corporation,
Its Manager
				
		 		 	By:	  	  

		 		 		  	Scott R. Brusseau, President
	
	“Tenant:”
	
	CLINICAL MICRO SENSORS, INC.,
a Delaware corporation dba GENMARK DIAGNOSTICS
		
	*By:	 	  

	Name:	 	  

	Title:	 	  

  

	*	NOTE:  

	  	Because Tenant is a corporation incorporated in a state other than California, Tenant shall deliver to Landlord a certified copy of a corporate resolution in a
form reasonably acceptable to Landlord authorizing the signatory(ies) to execute this Second Amendment to Lease. 

  
 -15-

 EXHIBIT “A” 

DEPICTION OF EXPANSION SPACE 
  

 

  
 EXHIBIT
“A” 
 -1- 

 EXHIBIT “B” 

EXPANSION SPACE TENANT WORK LETTER 

THE CAMPUS CARLSBAD, LLC, a Delaware limited liability company (“Landlord”) and CLINICAL MICRO
SENSORS, INC., a Delaware corporation dba “GENMARK DIAGNOSTICS, INC.” (“Tenant”) as of this
18th day of January, 2012, are executing simultaneously
with this Tenant work letter (“Work Letter”), a written Settlement and Release Agreement and Second Amendment to Lease (“Second Amendment”) covering the Expansion Space as described in the Second Amendment.

 This Work Letter defines the scope of tenant improvements and mezzanine expansion work that Landlord is to construct at the
Expansion Space only. 
 This Work Letter is part of the Lease (as defined in the Second Amendment and amended thereby) and is
subject to its terms and conditions. Terms which have initial capital letters and are not otherwise defined in this Work Letter shall have the meanings given them in the Second Amendment. In consideration of the mutual covenants herein, Landlord and
Tenant mutually agree as set forth below. 
 SECTION 1 — IMPROVEMENTS; PLANNING AND DOCUMENTS 

1.1 Construction of Tenant Improvements and Tenant Work. 
 1.1.1 Construction of Tenant Improvements. As part of the Landlord’s Work, Landlord agrees to furnish, at Tenant’s sole cost and expense, but subject to reimbursement of a portion thereof
from the Tenant Improvement Allowance (as provided in Section 3.1 below), all of the material, labor and equipment as may be reasonably necessary to construct the Tenant Improvements (as such term is defined in Section 1.3.6 below and
referring to the Expansion Space Tenant Improvements (as defined in Section 3 of the Second Amendment only) in substantial conformance with the T.I. Plans and Specifications (as such term is defined in Section 1.3.8 below). 

1.1.2 Construction of Tenant Work. Tenant Work (defined below) shall be furnished and installed by Tenant at Tenant’s sole
cost and expense. 
 1.2 Construction of Landlord’s Work. The “Landlord’s Work” shall mean and
consist of the Landlord Mezzanine Work (as defined in Section 6 of the Second Amendment, and as provided in Section 1.3.1 below) and the Tenant Improvements (as defined in Section 1.3.6, as provided in Section 1.1.1 above).
Subject to the terms and conditions of this Work Letter, Landlord agrees to furnish all of the material, labor and equipment as may be reasonably necessary to construct the Landlord’s Work in substantial conformance with the T.I. Plans and
Specifications (as such term is defined in Section 1.3.8 below). Landlord shall use its commercially reasonable efforts to endeavor to achieve Substantial Completion (as such term is defined below) of the Landlord’s Work by July 1,
2013 (the “Estimated Date of Substantial Completion”). 
 1.3 Plans and Specifications. 

1.3.1 Landlord’s Mezzanine Work. Landlord’s Mezzanine Work shall have the meaning ascribed to it in Section 6 of the
Second Amendment and shall be completed by Landlord, at Landlord’s sole cost and expense (except as hereinafter provided) at Landlord’s sole cost and expense pursuant to the T.I. Plans and Specifications relating to the same.
Landlord’s Mezzanine Work will be completed by Landlord as a bid alternate to the T.I. Plans and Specifications and Landlord and Tenant agree and acknowledge that the Contractor (as defined in Section 3.3.3 below) selected to construct the
Tenant Improvements will complete Landlord’s Mezzanine Work pursuant to Landlord’s reasonable construction schedule but concurrently with the construction of the Tenant Improvements. 

1.3.2 Intentionally Omitted. 
 1.3.3 Space Plan. “Space Plan” shall mean a layout of the Landlord’s Work in the entire Expansion Space as prepared by Designcorp (“Architect”), incorporating
the 

  
 EXHIBIT
“B” 
 Page 1 of 14 

 
Manufacturing/Lab Layout (as provide in Section 1.3.3(a) below), and designating the location and preliminary design of all counters, fixtures, demising walls (it being agreed that the
Tenant Improvements must include the installation of two (2) new stairs to the mezzanine located in the Expansion Space (as expanded by Landlord’s Mezzanine Work), related stairway partitions and two (2) skylights over such new
stairs) to be included in the Expansion Space as the Tenant Improvements (collectively, the Stairs & Skylights). The Space Plan shall include the entirety of the Expansion Space with a warehouse component comprising not more than a
total of 5,000 square feet of the Expansion Space), including, without limitation (i) the MEP/Lab Program and the Manufacturing/Lab Layout (as hereinafter defined), as prepared by Tenant’s MEP/Lab Consultant(s) (as hereinafter defined) in
coordination with the Architect, (ii) a detailed description of all other fixtures and equipment required by Tenant as part of the Tenant Improvements (including locations of the same) contained in the Expansion Space such that mechanical,
plumbing and electrical loads may be calculated and construction/engineering drawings may be produced and (iii) a detailed description of the Landlord’s Mezzanine Work as set forth in Section 6 of the Second Amendment (which shall be
included as a bid alternate and paid for by Landlord as set forth in Section 6 of the Second Amendment). 
 (a) Manufacturing/Lab Layout. Tenant shall submit a list of one or more consultants (but not more than a total of three (3) consultants), comprising a third (3rd) party architect and/or engineers and/or other qualified
consultants retained separately by Tenant for the purpose of the Manufacturing/Lab Layout and the MEP/Lab Program and reasonably approved in advance by Landlord (collectively, the “Tenant’s MEP Consultant(s)”), it being agreed
that Tenant shall submit the proposed Tenant’s MEP Consultant(s) designated by Tenant to perform the design work associated with the MEP/Lab Layout by written notice to Landlord on or before that date which is the earlier of (a) May 1,
2012 and (b) concurrently with delivery of Tenant’s Ready to Commence Construction Notice (as defined in 1.3.3(b) below). Landlord’s failure to approve or reasonably disapprove any of the Tenant’s MEP Consultant(s) within five
(5) business days following receipt of such notice (or any subsequent notice adding or replacing any Tenant’s MEP Consultant(s) retained by Tenant) shall be deemed Landlord’s approval of the subject Tenant’s MEP Consultant(s)
submitted to Landlord for its approval. Following Landlord’s approval (or deemed approval) of each of the Tenant’s MEP Consultant(s) for the Manufacturing/Lab Layout design work, Tenant shall arrange for those MEP/Lab Consultant(s)
participation in the Landlord’s space planning meetings (as described in Section 1.3.3(b) below) as required for the Manufacturing/Lab Layout to be completed and delivered to Architect, for incorporation into the Space Plans, on or before
that date (the “Manufacturing/Lab Layout Deadline”) which is the earlier of: (i) July 1, 2012, and (ii) thirty (30) days after Tenant’s delivery of Tenant’s Ready to Commence Construction Notice (if Tenant
elects to deliver such a notice); provided that any delays in the completion of the Space Plans that are caused by Tenant’s failure to engage the Tenant’s MEP Consultant(s) or any of them unless and as required or to thereafter cause such
Tenant’s MEP Consultant(s) to act reasonably in coordinating the design of the Manufacturing/Lab Layout with the Architect during the Space Planning Period (as defined in Section 1.3.3(b) below) shall be a Tenant Delay to the extent
completion of the Space Plans are delayed beyond the Scheduled Space Plan Completion Date (as defined in Section 1.3.3(b) below) as a result of such Tenant Delays. The “Manufacturing/Lab Layout” shall consist of the preliminary
design and layout of the manufacturing, lab and warehouse areas of the Expansion Space, showing the general location of Tenant’s manufacturing and lab equipment, warehouse improvements and laboratory space, along with preliminary mechanical,
electrical and plumbing system improvements and alterations for Tenant’s manufacturing, lab and warehouse operations, as well as the location and specification of all equipment and their requirements in the manufacturing, lab and warehouse
areas of the Expansion Space. 
 (b) Space Planning Period. Architect shall be retained by Landlord to prepare the Space
Plan on or before June 1, 2012 (the “Space Planning Commencement Date”), and commencing on June 1, 2012 and thereafter on a weekly basis (or such other basis as Landlord and Architect shall reasonably require)
Tenant’s Representative (as identified in this Work Letter below) and the Tenant’s MEP Consultant(s) (as required by Tenant, if the meeting pertains to the Manufacturing/Lab Layout) shall meet with Landlord and Landlord’s Architect
for purposes of commencing preparation of and thereafter diligently pursuing to completion the Space Plan such that the Space Plan shall be fully approved by Landlord and Tenant on or before September 1, 2012 (as such date may be accelerated
pursuant to the following sentence, the “Scheduled Space Plan Completion Date”; with the period between the Space Planning Commencement Date and the date of final approval (or deemed approval) of the Space Plan by

  
 EXHIBIT
“B” 
 Page 2 of 14 

 
Tenant (as hereinafter provided) sometimes referred to herein as the “Space Planning Period”). However, Landlord and Tenant hereby agree that Tenant in its sole election may
elect to accelerate the Estimated Date of Substantial Completion and consequently, the July 1, 2013 date set forth in clause (i) of Section 9.3 of the Summary (as modified by Clause (d) of the Second Amendment), and the Expanded
Premises Commencement Date to an earlier date by delivering written notice to Landlord (“Tenant’s Ready to Commence Construction Notice”) to Landlord prior to May 1, 2012 in which event the May 1, 2012 and
June 1, 2012 dates set forth in this Section 1.3.3 above and consequently, the July 1, 2013 date set forth in clause (i) of Section 9.3 of the Summary (as modified by Clause (d) of the Second Amendment), and the
Expanded Premises Commencement Date (and every other date in this Work Letter for completion of any requirement or delivery of any deliverable as an obligation of Landlord or Tenant or any of their respective agents, employees and contractors under
this Work Letter) will be advanced by one day for each day prior to May 1, 2012 on which Tenant delivers the Tenant’s Ready to Commence Construction Notice to Landlord in accordance with this Section 1.3.3(b). Tenant shall approve or
reasonably disapprove the Space Plan or any revisions thereto within five (5) business days after Landlord or Architect delivers the Space Plan or such revisions to Tenant. Tenant’s failure to reasonably disapprove the Space Plan or any
revisions thereto by written notice to Landlord (which notice shall specify in detail the reasonable reasons for Tenant’s disapproval) within said five (5) business day period shall be deemed to constitute Tenant’s approval of the
Space Plan or such revisions. 
 1.3.4 MEP/Lab Program. “MEP/Lab Program” shall mean a final layout of
the manufacturing, lab and warehouse space (which will ultimately be consistent with the Manufacturing/Lab Layout), and designation of all required details and specifications relating to Tenant’s proposed mechanical, electrical and plumbing and
lab uses, and warehouse improvements, in the Expansion Space, such that mechanical, plumbing and electrical loads may be calculated and MEP fully engineered drawings may be produced. The MEP/Lab Program shall be prepared by Tenant’s MEP
Consultant(s) and submitted to Landlord on or before June 1, 2013. The Manufacturing/Lab Layout shall be prepared by Tenant’s MEP Consultant(s) and submitted to Landlord on or before July 1, 2012 as set forth in Section 1.3.3
above, so that MEP/Lab Program and Manufacturing/Lab Layout (both of which shall have been fully approved by Tenant) is completed during the Space Planning Period. Landlord’s approval of the MEP/Lab Program shall not be unreasonably withheld.
Landlord may approve or reasonably disapprove the MEP/Lab Program in a writing delivered to Tenant within five (5) business days of Landlord’s receipt of the MEP/Lab Program. If Landlord expressly and reasonably disapproves the MEP/Lab
Program, then Landlord shall, as part of its disapproval notice, (x) approve those portions which are acceptable, and (y) disapprove those portions which are not acceptable, specifying the reasons for such disapproval and describing the
changes Landlord requests for each item disapproved. Landlord’s failure to deliver its approval or reasonable disapproval notice within such five (5) business day period shall be deemed Landlord’s approval of the MEP/Lab Program so
submitted. Within ten (10) business days following Landlord’s reasonable disapproval of any portion of MEP/Lab Program, Tenant shall have the MEP/Lab Program revised to incorporate the changes requested by Landlord and deliver the revised
MEP/Lab Program to Landlord for Landlord’s review and approval pursuant to the procedure set forth above. This process shall be repeated until the MEP/Lab Program is approved. 

1.3.5 MEP Fully Engineered Drawings. “MEP Fully Engineered Drawings” shall mean a complete set
of engineered MEP drawings, reflecting the final design of the MEP mechanical, plumbing and electrical to be incorporated into the T.I. Construction Drawings and incorporating the MEP/Lab Program as approved (or deemed approved) by Landlord. The MEP
Fully Engineered Drawings shall be prepared by third
(3rd) party engineers retained by Landlord for such
purpose, in consultation with the Tenant’s MEP Consultant(s), if Tenant so requests. Landlord shall use commercially reasonable efforts to cause the MEP Fully Engineered Drawings to be completed within forty-five (45) days following
Landlord’s approval (or deemed approval of Tenant’s Manufacturing/Lab Layout. Tenant shall approve or reasonably disapprove the MEP Fully Engineered Drawings or any revisions thereto within five (5) business days after Landlord or
Landlord’s third (3rd) party consultant delivers
the MEP Fully Engineered Drawings or such revisions to Tenant. If Tenant expressly and reasonably disapproves the MEP Fully Engineered Drawings, then Tenant shall, as part of its disapproval notice, (a) approve those portions which are
acceptable, and (b) disapprove those portions which are not acceptable, specifying the reasons for such disapproval and describing the changes Tenant requests for each item disapproved. Tenant’s failure to reasonably disapprove the MEP
Fully Engineered 

  
 EXHIBIT
“B” 
 Page 3 of 14 

 
Drawings or any revisions thereto by written notice to Landlord (which notice shall specify in detail the reasonable reasons for Tenant’s disapproval) within said five (5) business day
period shall be deemed to constitute Tenant’s approval of the MEP Fully Engineered Drawings or such revisions. 
 1.3.6
Tenant Improvements. “Tenant Improvements” shall mean those portions of the Expansion Space identified in the T.I. Plans and Specifications (as are generally consistent with the Space Plan), which are the responsibility of
Contractor to construct. The Tenant Improvements shall be based on the approved T.I. Plans and Specifications utilizing Landlord’s Building Standards (as such term is defined in Section 8.2 of the Original Lease) described on
Exhibit “I” attached to the Original Lease and incorporated herein; provided, however, that such improvements may be upgraded subject to Landlord’s prior written consent and the terms of this Work Letter. Landlord
and Tenant hereby agree that any improvements depicted or specified in the MEP/Lab Program and Manufacturing/Lab Layout as approved (or deemed approved) by Landlord shall be incorporated into the T.I. Plans and Specifications for the Tenant
Improvements by Architect irrespective of whether such improvements are non-Building Standard (with the understanding that Landlord shall raise any such objections at the time of its approval or disapproval of the MEP/Lab Design, and not thereafter
if the MEP/Lab Design is approved or deemed approved). 
 1.3.7 T.I. Construction Drawings. “T.I. Construction
Drawings” shall mean 1/4 or 1/8 scale construction drawings for the Tenant Improvements containing all information reasonably necessary to construct the Tenant Improvements, which drawings shall be consistent with the approved Space Plan,
the approved MEP/Lab Program, and the approved MEP Fully Engineered Drawings. 
 1.3.8 T.I. Plans and Specifications.
“T.I. Plans and Specifications” shall mean collectively the approved (or deemed approved) Space Plan, the approved MEP/Lab Program, the approved MEP Fully Engineered Drawings and the T.I. Construction Drawings, and all related
plans, drawings, specifications and notes developed or prepared in connection therewith. 
 1.3.7 Preparation of Tenant
Improvement Documents. 
 1.3.7.1 Architect. As set forth in Section 1.3.3, Landlord and Tenant have mutually
agreed that Landlord shall engage Designcorp for the preparation of the Space Plan and the T.I. Construction Drawings. 

1.3.7.2 T.I. Construction Drawings. Landlord shall deliver to Tenant the proposed T.I. Construction Drawings on or before the date
that is ten (10) weeks following the date upon which the Space Plan shall have been fully approved or deemed approved by Landlord and Tenant. The T.I. Construction Drawings shall be subject to the approval of Landlord and Tenant, which approval
shall not be unreasonably withheld (it being agreed that it shall not be unreasonable for Tenant to withheld its approval if the T.I. Construction Drawings materially deviate from the approved (or deemed approved) MEP Program, Manufacturing/Lab
Layout and/or Space Plan). Landlord or Tenant may approve or disapprove the T.I. Construction Drawings in a writing delivered to Landlord or Tenant, as the case may be, within five (5) business days of such party’s receipt of the T.I.
Construction Drawings. If Landlord or Tenant expressly disapproves the T.I. Construction Drawings, then Landlord or Tenant, as the case may be, shall, as part of its disapproval notice, (i) approve those portions which are acceptable, and
(ii) disapprove those portions which are not acceptable, specifying the reasons for such disapproval and describing the changes the disapproving party requests for each item disapproved, provided Tenant may only disapprove the T.I. Construction
Drawings if same materially deviates from the Space Plan approved by Tenant pursuant to this Work Letter (as determined by Tenant in its reasonable discretion). Landlord or Tenant’s failure to deliver its approval or disapproval notice within
such five (5) business day period shall be deemed such party’s approval of the T.I. Construction Drawings so submitted. Within ten (10) business days following either party’s disapproval of any portion of the T.I. Construction
Drawings, Landlord shall have the T.I. Construction Drawings revised to incorporate the changes requested by the disapproving party and deliver the revised T.I. Construction Drawings to both Landlord and Tenant. Tenant acknowledges that Landlord is
relying on Tenant’s timely submittal of the MEP/Lab Program and Manufacturing/Lab Layout and approval of the T.I. Construction Drawings in order to allow Landlord to attempt to deliver the Expansion Space on the Estimated Date of Substantial
Completion. Accordingly, for each day which passes after the date(s)/time 

  
 EXHIBIT
“B” 
 Page 4 of 14 

 
frames required for performance for such delivery of the MEP/Lab Program and Manufacturing/Lab Layout and/or approval of the Space Plan, the MEP Fully Engineered Drawings and the T.I.
Construction Drawings, but prior to Tenant performing such obligations, shall constitute a Tenant Delay (as such term is defined hereinbelow). 
 1.3.7.3 Ownership. Tenant hereby assigns to Landlord all of Tenant’s present and future right, title and interest in and to the T.I. Plans and Specifications, including, without limitation,
the Space Plan, the MEP/Lab Program, the MEP Fully Engineered Drawings and the T.I. Construction Drawings. 
 1.4 Building
Permits. Landlord shall be responsible for seeking a building permit necessary for the construction of the Tenant Improvements. Tenant shall be responsible for obtaining all other permits and governmental approvals relating to Tenant’s
operations in the Expansion Space (including, by way of example only, any hazardous materials permits and FDA approvals). Landlord shall pay for such building permit relating to the Tenant Improvements only out of the Tenant Improvement Allowance.
If a change to the approved T.I. Plans and Specifications is required by any governmental authority as a condition to obtaining a building permit, such change shall be made to the T.I. Plans and Specifications and deemed to have been approved by
Tenant. Any increase in construction cost due to such change shall be charged to the Tenant Improvement Allowance, or, if the Estimated Construction Costs exceeds the sum of the Tenant Improvement Allowance, then such excess shall be deemed an
Excess Cost (as such term is defined herein) to be paid by Tenant, however, the same shall be due and payable by Tenant within five (5) days of Landlord’s request therefor for purposes of timely obtaining the applicable building permit or
other approval(s). The parties shall cooperate with each other as may be reasonably necessary to obtain the building permit and any and all other approvals, as appropriate. Landlord shall use its commercially reasonable efforts to obtain the
necessary building permits and approvals for the approved T.I. Plans and Specifications by the date which is four (4) weeks following Tenants approval or deemed approval of the final approved T.I. Construction Drawings. Tenant acknowledges that
Landlord is relying upon the timely acquisition of the Tenant Improvements building permits and approvals so that Landlord may attempt to Substantially Complete the Tenant Improvements by the Estimated Date of Substantial Completion. 

1.5 Condition of Expansion Space; Limitation. Except as may otherwise expressly be provided in the Second Amendment and this Work
Letter (and without affecting Landlord’s obligations under Section 1.2 of the Original Lease, or any other warranty of Landlord contained therein with respect to the Building or Project), Landlord makes no express or implied warranties or
representations to Tenant with regard to the Expansion Space or the Project. However, Landlord shall deliver the Premises in the condition required by the Second Amendment and this Work Letter. 

1.6 Approvals. After approval (or deemed approval) of the Space Plan, MEP/Lab Program, Manufacturing/Lab Layout, MEP Fully
Engineered Drawings and the T.I. Plans and Specifications as provided herein, no changes, modifications or alterations may be made thereto by either Tenant or Landlord without the prior written consent of the other party to this Work Letter, which
consent shall not be unreasonably withheld, conditioned or delayed; provided, however, that Tenant’s consent shall not be required (but notice shall be provided to Tenant’s Representative) for any changes (a) that are required by any
governmental agency with jurisdiction over the Building, or the applicable standards of the American Insurance Association (formerly, the National Board of Fire Underwriters) and the National Electrical Code as required by Landlord’s insurance
carrier for the issuance of insurance policies required to be maintained under the Lease; (b) as a result of field conditions, or (c) to substitute reasonably equivalent materials to avoid unanticipated delays, strikes or shortages, or
(d) do not otherwise (i) materially deviate from the T.I. Plans and Specifications (as determined by Landlord in its reasonable discretion), or (ii) result in any material increased cost to Tenant for the Landlord’s Work
(“Authorized Change Directives”); provided that for purposes of clause (b)(iii) of the foregoing limitations on Authorized Change Directives, changes that do not exceed $15,000 per change order line item, or $70,000 in the
aggregate, which Landlord reasonably determines are reasonably required to achieve Substantial Completion of the Tenant Improvements on or before July 1, 2013 shall not be considered to materially increase the cost to Tenant of the
Landlord’s Work. The costs of any such Authorized Change Directives, and any Change Order requested by Tenant and approved by Landlord, to the T.I. Plans and Specifications are to be included within the Landlord Costs (as such term is defined
below) with any excess to be paid by Tenant as 

  
 EXHIBIT
“B” 
 Page 5 of 14 

 
Excess Costs (defined below). Any changes to the T.I. Plans and Specifications requested by Tenant after approval thereof, other than any changes as may be made by Landlord pursuant to
clauses (a), (b), (c) and/or (d) above in this Section 1.6, shall constitute a Change Order (as such term is defined below). 
 1.7 Costs. All costs and fees associated with the preparation of the T.I. Plans and Specifications, including, without limitation, all consultant or subcontractor design fees shall be paid for out
of the Tenant Improvement Allowance in accordance with Section 3 below, except as may be expressly set forth otherwise herein. The Space Plan, T.I. Construction Drawings and T.I. Plans and Specifications shall be prepared by Architect (provided
that the Manufacturing/Lab Layout and the MEP/Lab Program shall be prepared by Tenant’s third (3rd) party consultant as set forth above and the MEP Fully Engineered Drawings shall be prepared by Landlord’s third (3rd) party consultant(s) as set forth above) or as otherwise agreed in a separate writing signed by Landlord and
Tenant. 
 1.8 SDG&E Savings by Design. Tenant acknowledges that Landlord desires to participate in the San Diego Gas
and Electric (“SDG&E”) Savings by Design program (“Program”). Tenant agrees to reasonably cooperate with Landlord in incorporating such applicable Program standards within the design and specifications for the
Tenant Improvements (the “Incorporated Program Items”). Tenant shall be entitled to a refund of Tenant’s proportionate share of any refund actually received by Landlord in connection with such Program to the extent such refund
is awarded in connection with the completion of the initial Tenant Improvements. 
 SECTION 2 — TENANT IMPROVEMENTS

 2.1 Tenant Improvements. The Tenant Improvements are and shall become Landlord’s property and shall be
surrendered to Landlord upon expiration or earlier termination of the Lease in accordance with the provisions of the Lease. 

2.2 Expansion Space Furnishings. It is expressly understood that Landlord’s obligation to construct Tenant Improvements in
the Expansion Space is limited to construction of the Tenant Improvements specifically contemplated by the T.I. Plans and Specifications to be constructed by Landlord. Tenant shall be solely responsible for the performance and expense of the design,
layout, provision, delivery, permitting and installation of any furniture, furnishings, equipment, and any other personal property Tenant will use at the Expansion Space. 
 SECTION 3 — TENANT IMPROVEMENT ALLOWANCE—COSTS 
 3.1 Tenant
Improvement Allowance. Landlord has agreed to contribute a one-time tenant improvement allowance for the cost of preparing the T.I. Plans and Specifications related to Tenant Improvements and toward the cost of constructing the Tenant
Improvements, (including, but not limited to, any necessary permits and approvals, and any necessary demolition work but excluding any costs of furniture, trade fixtures, equipment or personal property and/or any non-Building Standard improvements,
all of which shall be Tenant’s sole responsibility) in an amount up to but not exceeding Sixty-One and 06/100 Dollars ($61.06) per square foot of the Expansion Space (“Tenant Improvement Allowance”). The Tenant Improvement
Allowance is based on the square feet of the Expansion Space, and the calculation of square feet for the Expansion Space shall be as determined by Landlord (but subject to Section 6 of the Second Amendment). Notwithstanding any provisions of
the Lease or this Work Letter to the contrary, Tenant shall be solely responsible for, and shall pay upon billing therefor, any and all costs and expenses relating in any way to the Tenant Improvements (including, but not limited to, the design,
permitting and construction thereof) in excess of the Tenant Improvement Allowance with respect to the work of construction of the Tenant Improvements by Landlord’s Contractor (“Excess Costs”). The total of all costs to be
incurred by Landlord in connection with the design and construction of the Tenant Improvements (including, without limitation, the costs to prepare the T.I. Plans and specifications, the obtainment of permits and completion of other pre-construction
work relating to the Tenant Improvements) shall be referred to as “Landlord Costs” and Landlord’s contribution toward Landlord’s Costs shall be limited to the Tenant Improvement Allowance. 

3.2 Intentionally Omitted. 

  
 EXHIBIT
“B” 
 Page 6 of 14 

 3.3 Cost of Tenant Improvement Work. 

3.3.1 Reserved. 
 3.3.2 Reserved. 
 3.3.3 Obtaining Estimated Construction Cost. The
contractor to be retained by Landlord as the contractor to construct the Tenant Improvements (“Contractor” or “Landlord’s Contractor”) shall be selected pursuant to the following procedure. Within three
(3) business days following Landlord’s and Tenant approval (or deemed approval) of the T.I. Construction Drawings, Landlord shall instruct Architect to deliver the T.I. Construction Drawings to the City of Carlsbad for review and to at
least five (5) general contractors mutually selected by Landlord and Tenant. Each such contractor shall be invited to submit a bid (on such bid form as Landlord shall designate either as a stipulated sum or a guaranteed maximum price) to
construct the Tenant Improvements. Each contractor shall be notified in the bid package of the time schedule for construction of the Tenant Improvements. All of the contractors submitting bids will obtain at least two (2) bids from each trade,
provided Landlord shall have the right to designate the subcontractors to be utilized in connection with work affecting the Building Structure and/or the Systems and Equipment. The bids shall be submitted promptly to Landlord and a reconciliation
shall be performed by Landlord to adjust inconsistent or incorrect assumptions so that a like-kind comparison can be made and a low bidder determined. All bids and Landlord’s reconciliation will be “open book” and shared fully with
Tenant. Landlord shall select the Contractor, subject to Tenant’s reasonable approval of such Contractor. The estimated cost of the Tenant Improvements set forth in the bid of the Contractor (as selected pursuant to the foregoing procedure),
along with all other costs related to the Tenant Improvements shall be referred to herein as the “Estimated Construction Cost” and Landlord shall deliver written notice (“Estimated Construction Cost Notice”) of the
same to Tenant. 
 3.3.4 Approval of Estimated Construction Cost by Tenant. Tenant shall, within three (3) business
days of receipt of the Estimated Construction Cost Notice, either: (i) agree in writing to pay the amount by which the Estimated Construction Cost exceeds the sum of the Tenant Improvement Allowance (“Additional Cost”), such
payment of the Additional Cost to be made in a cash lump sum within five (5) business days following Tenant’s receipt of the Estimated Construction Cost Notice, or (ii) revise the T.I. Plans and Specifications (in a manner reasonably
acceptable to Landlord) so that the Estimated Construction Cost is either (a) no more than the Tenant Improvement Allowance, or (b) in excess of the Tenant Improvement Allowance, by no more than the amount of Additional Cost which Tenant
agrees to pay, such payment of the Additional Cost to be made in a cash lump sum within five (5) business days following Tenant’s receipt of the Estimated Construction Cost Notice. If Tenant elects to revise the T.I. Plans and
Specifications in order to reduce the Estimated Construction Cost, the period of time between the date following Tenant’s election to revise the T.I. Plans and Specifications and the date of the approval of the revised Estimated Construction
Cost by Tenant shall constitute a Tenant Delay. The failure of Tenant to so respond within the three (3) business day period following receipt of the Estimated Construction Cost Notice shall be a Tenant Delay as to each day thereafter until
Tenant so responds in writing. Upon approval by Tenant, Landlord shall be authorized to proceed with the Tenant Improvements in accordance with the approved T.I. Plans and Specifications. All costs arising out of any changes to the T.I. Plans and
Specifications and/or the Estimated Construction Cost (except to the extent attributable to any deviation from the T.I. Construction Drawings approved by Tenant or otherwise required by Applicable Law), including, without limitation, any
re-engineering, estimating, printing of drawings, costs of any space planner, architect, tenant improvement coordinator, engineering consultants and other consultants, management, and any other incidental expenses made pursuant to such Tenant
requests, shall be chargeable against the Tenant Improvement Allowance, with any excess to be paid by Tenant as Excess Costs. 

3.4 Landlord Costs for Tenant Improvements. Any and all costs incurred by Landlord in connection with the design, construction and
installation of the Tenant Improvements in conformance with the T.I. Plans and Specifications and this Work Letter, including, but not limited to, any demolition or modification of any existing improvements as may be necessary to accomplish
construction of the Tenant Improvements in conformance with the T.I. Plans and Specifications, and any other measures taken by Landlord to accomplish Landlord’s construction of the Tenant Improvements, including but not limited to governmental
permits and approvals, shall be chargeable against the Tenant Improvement Allowance, with any 

  
 EXHIBIT
“B” 
 Page 7 of 14 

 
excess to be paid by Tenant as Excess Costs. A construction management fee shall be paid to Landlord in the amount equal to two (2%) of the aggregate of all such Landlord Costs and all
Excess Costs. Landlord shall have the right to charge such fee against the Tenant Improvement Allowance, with any excess to be paid by Tenant as Excess Costs. However, no bonding costs associated with any contractor proposed by Landlord shall be
payable as an Approved Construction Cost or Excess Cost. 
 3.5 Tenant Costs for Tenant Improvements. Tenant shall be
solely responsible for all Additional Costs. Failure by Tenant to timely deliver payment therefor as provided above shall prohibit Landlord from proceeding with the Tenant Improvements, shall constitute a Tenant Delay for each day of delay in
delivering the cash lump sum equal to the Additional Costs as provided above and, at Landlord’s sole option, shall constitute a default by Tenant under this Work Letter and the Lease. Notwithstanding any provision of the Lease or this Work
Letter to the contrary, Tenant shall pay for all Excess Costs. Notwithstanding any Additional Costs payments which may be made by Tenant, if at any time (including, without limitation, whether prior to, upon or after Substantial Completion) Landlord
determines that Excess Costs exceed or will exceed that paid by Tenant (or that Excess Costs are otherwise due from Tenant) then Landlord shall have the right from time to time to bill Tenant for such Excess Costs, and Tenant shall pay to Landlord
all such amounts so billed within ten (10) days after Tenant’s receipt of billing therefor. Tenant’s failure to timely pay any such amounts shall constitute a default by Tenant under this Work Letter and the Lease. 

SECTION 4 — CONSTRUCTION OF TENANT IMPROVEMENTS 
 4.1 Completion of Tenant Improvements. Landlord shall be responsible for the construction of the Tenant Improvements in substantial conformance with the approved T.I. Plans and Specifications,
subject to the terms and conditions of the Lease and this Work Letter. Upon Substantial Completion (as such term is defined below), Landlord and Tenant shall conduct an inspection of the Expansion Space and thereafter provide a “punchlist”
identifying the corrective work of the type commonly found on an architectural punchlist with respect to the Tenant Improvements, which list shall be based on whether such items were required by the approved T.I. Plans and Specifications, as
reasonably determined by Landlord. Within five (5) business days after delivery of the punchlist, Landlord shall instruct Contractor to commence the correction of the punchlist items and thereafter pursue such work to completion. The punchlist
procedure to be followed by Landlord and Tenant shall in no way limit Tenant’s obligation to occupy the Expansion Space under the Lease (as amended by the Second Amendment) nor shall it in any way excuse Tenant’s obligation to pay Rent as
provided under the Lease (as amended by the Second Amendment), unless such punchlist items actually preclude Tenant from occupying substantially all of the Expansion Space. Landlord warrants that, as of Landlord’s delivery of the Expansion
Space to Tenant, the Tenant Improvements shall be in compliance with all laws applicable thereto as of the issuance of the building permits therefor. 
 4.2 Progress Reports; Site Meetings. Landlord shall conduct weekly construction meetings and provide to Tenant bi-monthly progress reports describing the condition and estimated schedule for
completing the Tenant Improvements (“Progress Reports”). In no event shall the Progress Reports be deemed to be a representation, warranty or an assurance by Landlord of the date of Substantial Completion or the cost or expense of
the Tenant Improvements, and Tenant specifically acknowledges that the Progress Report is only an estimate by Landlord based on information provided to Landlord. Except to the extent attributable to Landlord’s willful misconduct, Landlord shall
have no liability or responsibility for any errors or inaccuracies in a progress report. In addition, Landlord shall coordinate on-site meetings of construction personnel as reasonably appropriate in order to implement the construction described in
this Work Letter. 
 4.3 Substantial Completion. “Substantial Completion” or “Substantially
Completed” as used herein shall mean all of the following have occurred: (i) delivery of a factually correct written notice to Tenant of the completion of construction of the Tenant Improvements in the Expansion Space substantially in
accordance with the approved T.I. Plans and Specifications with the exception of minor details of construction installation, decoration, or mechanical adjustments, punchlist items, (ii) expiration of the Early Access Period (as defined in
Section 5.1) (iii) the City of Carlsbad has issued a final inspection approval, certificate of occupancy (or equivalent), a temporary certificate of occupancy (or equivalent) or other equivalent authorization, or Tenant has occupied and
obtained the beneficial use of the 

  
 EXHIBIT
“B” 
 Page 8 of 14 

 
Expansion Space. Tenant agrees that if Landlord shall be delayed in causing such work to be Substantially Completed as a result of any of the events described herein (or elsewhere in the Lease)
as a “Tenant Delay,” then such delay shall be the responsibility of Tenant. In any such event, Substantial Completion shall be deemed to have occurred the earlier of: (a) the date of Substantial Completion or (b) the date when
Substantial Completion would have occurred if there had been no Tenant Delay. Landlord shall not be required to work on an overtime basis. For the purposes of this Work Letter, a “Tenant Delay” is defined as any delay directly or
indirectly resulting from: (1) Tenant’s failure to comply with any time frames set forth herein or in the Lease (including the deadline set forth in Section 1.3.3 for (v) Tenant to meet with Landlord and Architect for purposes of
preparing the Space Plan, (w) Tenant’s approval of the Space Plan, (x) Tenant’s delivery of the names of Tenant’s third party consultant and/or submittal and/or re-submittal (to the extent of any revisions required by
Landlord) of the MEP/Lab Program and/or Manufacturing/Lab Layout, (y) Tenant’s approval of the MEP Fully Engineered Drawings and (z) Tenant’s approval of the T.I. Construction Drawings as such time frames may be adjusted in
accordance with Section 1.3.3(b) as a result of Tenant’s timely delivery of a Tenant’s Ready to Commence Construction Notice); (2) any changes in any stage of the T.I. Plans and Specifications requested by Tenant after
Landlord’s and Tenant’s approval of such stage, including, without limitation, any Change Order or changes made to reduce the Estimated Construction Cost; (3) Tenant’s failure to timely furnish any documents required herein or to
timely approve any item or any cost estimates, the Estimated Construction Costs or any Change Orders, as required herein; (4) Tenant’s request for materials, finishes, or installations other than Landlord’s Building Standard items;
(5) Tenant’s failure to timely perform any act or obligation imposed on Tenant by the Lease or this Work Letter as and when requested thereunder or hereunder; (6) Tenant’s failure to assemble its systems furniture to satisfy fire
and building inspector requirements to procure a certificate of occupancy (or equivalent); or (7) any other delay otherwise caused by Tenant, its officers, directors, owners, agents, invitees, permittees, employees or contractors which operates
to delay Landlord’s Substantial Completion of the Tenant Improvements, as reasonably determined by Landlord. Notwithstanding the foregoing, nor anything set forth in Section 5.3 below relating to Landlord Delays, there shall be no Tenant
Delay or Landlord Delay if the effect such delays, in the aggregate, do not delay Substantial Completion of the Landlord’s Work beyond July 1, 2013; provided, however, that if Tenant delivers a Tenant’s Ready to Commence Construction
Notice prior to May 1, 2012, then Landlord Delays and Tenant Delays shall be used in determining any acceleration or delay of the Expanded Premises Commencement Date regardless of the Estimated Date of Substantial Completion. 

4.4 Tenant’s Right to Audit. Landlord shall keep detailed and accurate books and records (including financial records) in
connection with the construction of the Tenant Improvements, and in accordance with customary standards for similar projects. Promptly following Substantial Completion of the Tenant Improvements, Landlord shall provide to Tenant a schedule together
with reasonable back-up information requested by Tenant (inclusive of all invoices, payment receipts to the extent the same were actually provided to Contractor and mechanics’ lien releases), showing the calculation of the actual Landlord Cost
and Excess Costs, and Tenant or its architects or other agents shall have the right, at Tenant’s sole cost and expense, to inspect and audit Landlord’s books and records relating thereto, so long as Tenant requests such inspection or audit
within sixty (60) days after receipt from Landlord of Landlord’s calculation of Landlord Costs. In the event that either Landlord’s calculation of Landlord Costs and Excess Costs and/or Tenant’s inspection and/or audit of
Landlord’s books and records determines that the Landlord Costs and Excess Costs are less than the sum of the Tenant Improvement Allowance and Additional Costs actually paid by Tenant to Landlord as set forth in Section 3.3.4, and as a
result, Tenant has actually overpaid the amount of Additional Costs, then Landlord shall promptly refund any overpayment by Tenant of Additional Costs in excess of the actual amount of Landlord Costs and Excess Costs. If the parties are unable to
agree upon the Landlord Costs and Excess Costs incurred in the construction of the Tenant Improvements, the parties agree that arbitration shall constitute the exclusive remedy for settlement of any such dispute. If either Landlord or Tenant desires
to exercise its right pursuant to this Section 4.4, such party shall deliver written demand for arbitration to the other party, setting out the basis for the controversy. Any arbitration proceeding undertaken pursuant to this shall be held in
front of a retired judge working with JAMS or another similar group, or if no such groups exists, a single neutral arbitrator shall be chosen by mutual agreement or, if the parties fail to agree, by the presiding judge of the San Diego Superior
Court upon ex parte application. The arbitration shall take place in San Diego, California. The decision of the arbitrator shall be conclusive, final and 

  
 EXHIBIT
“B” 
 Page 9 of 14 

 
binding upon Landlord and Tenant. Judgment upon the decision of the arbitrator may be entered in any court of competent jurisdiction. The cost of such arbitration (including reasonable
attorneys’ fees incurred therein) shall be borne by the losing party as determined by the arbitrator. 
 SECTION 5 —
TENANT WORK 
 5.1 Finish Work. All finish work and decoration and other work desired by Tenant and not
included within the Tenant Improvements as set forth in the approved T.I. Plans and Specifications, including specifically, without limitation, those items of furniture systems, computer systems, cabling, telephone systems, telecommunications
systems audio visual equipment, security systems not depicted as part of the Tenant Improvements on the T.I. Plans and Specifications (“Tenant Work” or “Tenant’s Work”) shall be furnished and installed by
Tenant at Tenant’s sole cost and expense and shall not be chargeable to Landlord or against the Tenant Improvement Allowance. If any Tenant Work is not set forth on the approved T.I. Plans and Specifications, Tenant must secure Landlord’s
prior written consent for such Tenant Work which consent of Landlord shall not be unreasonably withheld. Landlord’s approval or disapproval of any plans or specifications for Tenant Work may be based on any of the following matters in addition
to any other matters reasonably considered by Landlord: (a) matters affecting the efficiency, operation and distribution of heating, ventilating, air-conditioning, electrical and plumbing systems, elevators, structural components, or any other
shell building or common area system(s); (b) matters affecting Landlord’s insurance coverage; (c) compliance with building codes and other laws, ordinances, regulations, rulings and interpretations; (d) compliance with
Landlord’s Building Standard items; (e) consent or approval rights of lenders; and (f) entrances on partial floors; provided that Landlord shall not disapprove any of Tenant’s Work for any of the foregoing reasons if such
furniture systems, computer systems, cabling, telephone systems, telecommunications systems audio visual equipment, security systems are similar to, or components of, such systems already located at the Premises (i.e. in the Existing Premises, or as
required to connect the Expansion Space equipment and systems to Tenant’s Common Area Equipment). Landlord has the right, exercisable in Landlord’s sole and absolute discretion, to require Tenant to remove all or any portion of such Tenant
Work upon the expiration or earlier termination of this Lease upon notice to Tenant of such removal requirement. Tenant shall not commence the construction or installation of any improvements or fixtures whatsoever in the Expansion Space, including,
specifically, but without limitation, the Tenant Work, without first securing satisfaction of all conditions thereto in the Lease and obtaining Landlord’s prior written approval (which shall not be unreasonably withheld, conditioned or delayed)
of: (i) Tenant’s contractor; (ii) detailed plans and specifications for the Tenant Work; and (iii) certificate(s) of insurance and/or copies of policies (as Landlord may request) as prescribed below. The required certificates of
insurance shall demonstrate that Tenant and Tenant’s contractor(s) maintain insurance coverage in amounts, types, form and with companies required under the Lease and all other insurance reasonably required by Landlord. All such certificates or
policies shall be endorsed to show Landlord (and any lender or other party Landlord may request) as an additional insured and the insurance shall be maintained by Tenant and/or Tenant’s contractor, as applicable, at all times during the
performance of the Tenant Work. Provided that such certificates of insurance are so furnished to Landlord prior to the commencement of the proposed Tenant Work, Landlord may not unreasonably withhold or condition its consent to the making of an
alteration or improvement unless the making or installation of the improvements or alterations would (w) adversely affect the Building Structure, (x) adversely affect the Building Systems and Equipment, (y) not comply with applicable
laws, or (z) affect the exterior appearance of the Building. Provided that Tenant and its agents do not interfere with Contractor’s work in the Building and the Expansion, Contractor shall allow Tenant and Tenant’s vendors access to
the Expansion Space at least thirty (30) days prior to the Substantial Completion of the Expansion Space (“Early Access Period”) for the purpose of performing the Tenant’s Work in the Expansion Space; provided that
Landlord shall give Tenant written notice (and such Early Access Period shall not commence until Landlord has delivered such notice) at least ten (10) days in advance of such Early Access Period in order for Tenant to schedule performance of
such work. Prior to Tenant’s entry into the Expansion Space as permitted by the terms of this Section 5.1, Tenant shall submit a schedule to Landlord and Contractor, for their approval, which schedule shall detail the timing and purpose of
Tenant’s entry. Tenant shall hold Landlord harmless from and indemnify, protect and defend Landlord against any loss or damage to the Building or Expansion Space and against injury to any persons caused by Tenant’s actions pursuant to this
Section 5.1. 

  
 EXHIBIT
“B” 
 Page 10 of 14 

 5.2 Obligations. All of the Tenant Work shall be undertaken and performed in strict
accordance with all applicable laws, the provisions of the Lease and the provisions of this Work Letter. 
 5.3 Landlord
Delay. The July 1, 2013 date set forth in clause (i) of Section 9.3 of the Summary (as modified by Clause (d) of the Second Amendment) or such earlier date if Tenant shall have delivered Tenant’s Ready to Commence
Construction Notice pursuant to its rights set forth in Section 1.3.3 of the Work Letter, shall be extended one (1) day for each day that Contractor is delayed in completing the Tenant Improvements in any portion of the Expansion Space as
a result of a “Landlord Delay.” Subject to the conditions of the last sentence of Section 4.3 above, the term “Landlord Delay” shall mean only an actual delay in the completion of the Tenant Improvements which is
caused by (a) the failure of Landlord to provide authorizations or approvals within the time periods set forth in this Work Letter, (b) the failure by Landlord to pay the Improvement Allowance when due under this Work Letter, (c) a
violation by Landlord of its obligations under the Lease (as amended by the Second Amendment) or this Work Letter, (d) the issuance of a stop work order by a governmental agency (but only to the extent caused for reasons within Landlord’s
reasonable control and not caused by the act or omission of Tenant, its agents, employees or contractors) and/or (e) Landlord’s failure to meet dates specified in the construction schedule for Landlord’s Mezzanine Work referred to in
Section 1.3.1 of this Work Letter, where such failure to meet such dates causes an actual delay in completion of the Tenant Improvements. 
 SECTION 6 — CHANGE ORDERS 
 Tenant may request changes in the Tenant
Improvements during construction only by written request to Landlord, or its designated representative, in substantially the form of Attachment “B” to the Exhibit “C” of the Original Lease, and as otherwise
approved by Landlord. All such changes will be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. Prior to commencing any change, Landlord has the right to prepare and
deliver to Tenant, a change order (“Change Order”) setting forth the additional time, if any, reasonably needed for such change and the total cost of such change (or reasonable estimated cost of such change if cost information is
delayed) which cost or estimated cost will include, but not be limited to, associated architectural, engineering, management and construction contractor’s fees. Within three (3) business days after delivery to Tenant of the Change Order,
Tenant shall deliver notice of approval, together with a lump sum cash payment equal to one hundred percent (100%) of the cost or estimated cost of the change set forth in the Change Order (“Payment”). If Tenant fails to
approve such Change Order and deliver the Payment within two (2) business days after delivery by Landlord, Tenant will be deemed to have withdrawn the proposed Change Order and Landlord will not proceed to perform the change. Upon
Landlord’s receipt of Tenant’s approval and Payment, Contractor will proceed to perform the change. Any and all delays arising from or in any way in connection with Tenant’s requests for changes or Change Orders shall be deemed Tenant
Delays. 
 SECTION 7 — RESPONSIBILITY FOR FUNCTION 

Landlord’s preparation and/or approval of any design or construction documents will not constitute any representation or warranty as
to the adequacy, efficiency, performance or desirability of the improvements contemplated therein; provided, however, Landlord shall use commercially reasonable efforts to ensure that the construction of all Tenant Improvements shall be accomplished
in a good and workmanlike manner, in substantial conformance with the approved T.I. Plans and Specifications, and in accordance with applicable laws in effect as of the date Landlord obtains permits for such Tenant Improvements. 

SECTION 8 — TENANT AND LANDLORD OBLIGATIONS 
 8.1 Risk of Loss. All materials, work, installations and decorations of any nature brought upon or installed in the Expansion Space before the Expanded Premises Commencement Date shall be at the
risk of the party who brought such materials or items onto the Expansion Space. Neither Landlord nor any party acting on Landlord’s behalf shall be responsible for any damage or loss or destruction of such items brought to or installed in the
Expansion Space by Tenant or its employees, agents or contractors prior to such date. 

  
 EXHIBIT
“B” 
 Page 11 of 14 

 8.2 Conformance with Laws. All Landlord’s Work and Tenant Work shall be done in
conformity with applicable codes and regulations of governmental authorities having jurisdiction over the Building and the Expansion Space and valid building permits and all other authorizations from appropriate governmental agencies when required,
shall be obtained by Landlord for the Landlord’s Work, and by Tenant for the Tenant Work and/or in connection with Tenant’s use or operations in the Expansion Space. 
 SECTION 9 — TENANT’S REPRESENTATIVE 
 Tenant has designated Paul
Ross (“Tenant’s Representative”) as its sole representative with respect to the matters set forth in this Work Letter, who shall have full authority and responsibility to act on behalf of Tenant as required in this Work Letter.
Tenant may change its representative under this Work Letter at any time by providing at least five (5) days prior written notice to Landlord. All inquiries, requests, instructions, authorizations and other communications with respect to matters
covered by this Work Letter from Landlord will be made to Tenant’s Representative (and its designated project manager if one is engaged by Tenant as permitted under Section 10 below). Landlord will communicate solely with Tenant’s
Representative and will not make any inquiries of or requests to, and will not give any instructions or authorizations to, any other employee or agent of Tenant with regard to matters covered by this Work Letter. 

SECTION 10 — LANDLORD’S REPRESENTATIVE AND TENANT’S PROJECT MANAGER 

Landlord has designated Jeffry A. Brusseau as its sole representative with respect to the matters set forth in this Work Letter, who shall
have full authority and responsibility to act on behalf of Landlord as required in this Work Letter, but who shall also reasonably cooperate with Tenant and Tenant’s Representative in good faith with respect to all matters relating to the
construction of the Tenant Improvements at no additional cost to Tenant (other than the construction management fee set forth in Section 3.4 above); provided that Tenant shall have the right in its sole discretion to retain its own project
manager from time to time (in which case, Landlord’s Representative shall reasonably cooperate with such project manager in good faith with respect to all matters relating to the construction of the Tenant Improvements), provided that the cost
of such replacement project manager shall be a cost of Tenant’s Work (and not chargeable to Landlord or against the Tenant Improvement Allowance). Landlord may change its representative under this Work Letter at any time by providing five
(5) days prior written notice to Tenant. All inquiries, requests, instructions, authorizations and other communications with respect to the matters covered by this Work Letter from Tenant will be made to Landlord’s representative. Tenant
will communicate solely with Landlord’s Representative and will not make any inquiries of or requests to, and will not give any instructions or authorizations to, any other employee or agent of Landlord, including Landlord’s architect,
engineers, and contractors or any of their agents or employees, with regard to matters covered by this Work Letter. 
 SECTION
11 — MISCELLANEOUS 
 11.1 Sole Obligations. Except as herein expressly set forth with respect to the Tenant
Improvements, Landlord or Tenant has no obligation to do any work with respect to the Expansion Space. Any other work in the Expansion Space which may be permitted by Landlord pursuant to the terms and conditions of the Lease, including any
alterations or improvements as contemplated in the Lease, shall be done at Tenant’s sole cost and expense and in accordance with the terms and conditions of the Lease. 
 11.2 Reserved. 
 11.3 Authority; Counterparts. Any person signing
this Work Letter on behalf of either Landlord or Tenant warrants and represents that such person has authority to do so. This Work Letter may be executed in counterparts, each of which shall be deemed an original, but all of which together
constitute one instrument. 
 11.4 Binding on Successors. Subject to the limitations on assignment and subletting
contained in the Lease, this Work Letter shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, legal representatives, successors and assigns. 

  
 EXHIBIT
“B” 
 Page 12 of 14 

 11.5 Landlord’s Approval Rights. Notwithstanding any provision of the Lease or
this Work Letter to the contrary, Landlord may withhold its approval of the Space Plan, the MEP/Lab Program, the approved MEP Fully Engineered Drawings and/or any revisions requested by Tenant to the T.I. Plans and Specifications, Change Orders or
any other work requested by Tenant which require work which: (i) exceeds or adversely affects the structural integrity of the Building, or any part of the heating, ventilating, air conditioning, plumbing, mechanical, electrical, communication
or other systems of the Project; (ii) is disapproved by the holder of any mortgage or deed of trust encumbering the Project at the time the work is proposed; (iii) would not be approved by a prudent owner of property similar to the
Project; (iv) violates the Declarations; (v) Landlord reasonably believes will increase the cost of operation or maintenance of the Project, the Common Area or any systems thereof; (vi) Landlord reasonably believes will reduce the
market value of the Premises or Project; (vii) does not conform to applicable building codes or is not approved by any governmental authority with jurisdiction over the Premises; (viii) is not a Building Standard item or an item of equal
or higher quality; (ix) in Landlord’s determination detrimentally affects the uniform exterior appearance of the Building; or (x) is reasonably disapproved by Landlord for any other reason not set forth herein. 

11.6 Time of the Essence; Defaults. Time is of the essence as to each and every term and provision of this Work Letter to be
performed by either Landlord or Tenant. Unless otherwise provided herein, in all instances where Tenant is required to approve an item, if no written notice of disapproval is given within the stated time period at the end of said period the item
shall automatically be deemed approved and the next succeeding time period shall commence. Any failure of Tenant to timely make any payment or perform any other obligation required of Tenant under this Work Letter shall constitute a default by
Tenant under this Work Letter and a default under the Lease (regardless of whether any provision of this Work Letter does or does not expressly state the same). The Work Letter is incorporated into the Lease by reference and made a part thereof.

 11.7 Force Majeure. Force Majeure (as that term is defined in Section 29.17 of the Original Lease) shall excuse
the performance of such party for a period equal to any such prevention, delay or stoppage, except the obligations imposed with regard to rent and other payments and charges to be paid by Tenant pursuant to the Lease or this Work Letter; provided
that no Force Majeure Delay shall be deemed to have occurred (and the right to claim such a delay shall be waived) if written notice of such event is not delivered by the party claiming a Force Majeure Delay within two (2) business days
following its alleged occurrence. 

  
 EXHIBIT
“B” 
 Page 13 of 14 

 11.8 Incorporation. All schedules and attachments referenced in this Work Letter and
attached hereto are incorporated herein by reference. This Work Letter is incorporated by reference in the Lease and all of the terms and provisions of the Lease are incorporated herein for all purposes. 

11.9 Construction Warranties. Landlord shall obtain customary warranties and guaranties from the Contractor
(“Contractor’s Warranty”) and the manufacturers of any equipment installed as part of the Tenant Improvements. If the Contractor’s Warranty is not expressly assigned to Tenant pursuant to the terms and conditions of the
Construction Contract, Landlord shall, upon receipt of written request from Tenant, use its good faith efforts to pursue its rights under any such warranties obtained by Landlord for the benefit of Tenant, and unless such efforts are required to
comply with Landlord’s compliance obligations under Section 1.2 of the Original Lease (with respect to the Expansion Space and related Systems and Equipment only) or its repair obligations under Section 7.1 of the Original Lease,
Landlord shall be under no obligation to incur any expense in connection with asserting rights under such warranties or guaranties against either the Contractor or any manufacturer. 

 

							
	“LANDLORD”:
	
	THE CAMPUS CARLSBAD, LLC,
a Delaware limited liability company
		
	By:	 	NEWPORT NATIONAL / THE CAMPUS
CARLSBAD, LLC, a California limited liability company
	Its:	 	Managing Member
			
		 	By:	 	Newport National Corporation,
a California corporation, Manager
				
		 		 	By:	  	  

		 		 		  	Scott R. Brusseau, President
	
	“TENANT”:
	
	CLINICAL MICRO SENSORS, INC.,
a Delaware corporation dba GENMARK DIAGNOSTICS
		
	*By:	 	  

	Name:	 	  

	Title:	 	  

 ACKNOWLEDGMENT 
 I have read and understand the Work Letter to which this Acknowledgment is attached and agree to act as Tenant’s representative pursuant to Section 9 of the Work Letter. 

 

					
	Dated:	  	  
	    	TENANT’S REPRESENTATIVE:
		  		    	  

		  		    	  

 I have read and understand the Work Letter to which this acknowledgment is attached and agree to act as Landlord’s
representative pursuant to Section 10 of the Work Letter. 
  

					
	Dated:	 	  
	    	LANDLORD’S REPRESENTATIVE:
		 		    	  

		 		    	Jeffry A. Brusseau

  
 EXHIBIT
“B” 
 Page 14 of 14

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00201-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00201-of-00352.parquet"}]]