Document:

EX-10.1

 Exhibit 10.1 

Execution Version 
 AMENDMENT
NO. 4 TO LOAN AND SECURITY AGREEMENT 
 THIS AMENDMENT NO. 4 TO LOAN AND SECURITY AGREEMENT (this “Amendment
No. 4”) is entered into as of June 24, 2016, by and among A.M. Castle & Co., a corporation organized under the laws of the state of Maryland (“Parent”), Total Plastics, Inc., a Michigan corporation
(“TPI”; and together with Parent, each individually a “US Borrower” and collectively, “US Borrowers”), A.M. Castle & Co. (Canada) Inc., a corporation organized under the laws of the
province of Ontario, Canada (“Canadian Borrower”; and together with US Borrowers, each individually a “Borrower” and collectively, “Borrowers”), the financial institutions from time to time party to
the Loan Agreement as lenders (individually, each a “Lender” and collectively, “Lenders”), and Wells Fargo Bank, National Association, in its capacity as agent (in such capacity, “Agent”) pursuant
to the Loan Agreement (as defined below) acting for and on behalf of the Secured Parties (as defined in the Loan Agreement). 
 R
E C I T A L S: 
 WHEREAS, Borrowers, certain affiliates of Borrowers as Guarantors,
the Lenders and the Agent entered into that certain Loan and Security Agreement, dated as of December 15, 2011, as amended by Amendment No. 1 to Loan and Security Agreement, dated as of January 21, 2014, Amendment No. 2 to Loan
and Security Agreement, dated as of December 10, 2014 and Amendment No. 3 to Loan and Security Agreement, dated as of February 8, 2016 (as the same now exists or may hereafter be amended, modified, supplemented, extended, renewed,
restated or replaced, the “Loan Agreement”) and the Other Documents (as defined in the Loan Agreement); 
 WHEREAS,
Borrowers have requested that Agent and Lenders (a) consent to the prepayment of certain Second Lien Notes and Non-Exchanged Notes and (b) agree to amend certain provisions of the Loan Agreement; and 

WHEREAS, Agent and the Lenders are willing to agree to such request on and subject to the terms and conditions set forth in this Amendment
No. 4. 
 A G R E E M E N T: 

NOW, THEREFORE, in consideration of the terms and provisions of this Amendment No. 4 and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 1. Existing Definitions. Unless
otherwise defined herein, capitalized terms used herein shall have the meanings set forth in the Loan Agreement. 
 2. Consent to Certain
Payments. Notwithstanding anything to the contrary in the Loan Agreement, but subject to the terms and conditions set forth in this Amendment No. 4, the parties agree that, from and after the Amendment No. 4 Effective Date, the
Borrowers may (a) prepay the Second Lien Notes (other than the Non-Exchanged Notes) in an aggregate principal 

 
amount not in excess of $27,500,000 and (b) repay the Non-Exchanged Notes in an aggregate principal amount not in excess of $6,000,000; provided, that, (i) in the case of
the foregoing clauses (a) and (b), immediately before and after giving effect to any such payment, the amount of Global Excess Availability (which for the avoidance of doubt shall be calculated after giving effect to the Availability Block)
shall be no less than $17,500,000, (ii) Administrative Borrower shall give prompt written notice to Agent of any such payment, (iii) Agent shall have received the amendment fee described in Section 6(b) below, and (iv) no Default
or Event of Default shall have occurred and be continuing either immediately before or after any such payment. 
 3. Additional
Definitions. As used herein, the following terms shall have the meanings given to them below and Section 1.2 of the Loan Agreement is hereby amended to include, in addition and not in limitation, the following definitions: 

“Amendment No. 4” shall mean Amendment No. 4 to Loan and Security Agreement, dated as of June 24,
2016, by and among Borrowers, Guarantors, Agent and Lenders, as the same now exists or may hereafter be amended, modified, supplemented, extended, renewed, restated or replaced. 

“Amendment No. 4 Effective Date” shall mean the first date on which all conditions set forth in Section 7
of Amendment No. 4 have been satisfied (or waived by Agent). 
 “Availability Block” shall mean $17,500,000;
provided, that, (a) Availability Block shall mean $8,750,000 from and after such time, if any, that the Administrative Borrower shall have delivered a Compliance Certificate to Agent pursuant to Section 9.7 or 9.8 of this
Agreement, demonstrating a Fixed Charge Coverage Ratio of not less than 1.00:1.00 for each of the six (6) preceding fiscal months, and (b) Availability Block shall mean $0 from and after such time, if any, that the Administrative Borrower
shall have delivered a Compliance Certificate to Agent pursuant to Section 9.7 or 9.8 of this Agreement, demonstrating a Fixed Charge Coverage Ratio of not less than 1.00:1.00 for the trailing twelve (12) month period then ended. 

4. Amendments to Definitions. 

(a) The definition of “Applicable Margin” in Section 1.2 of the Loan Agreement is hereby amended by deleting the pricing grid
set forth therein in its entirety and replacing it with the following: 
  

									
	Tier	  	Quarterly Average
Undrawn Availability	  	 Applicable

Margin for Base
 Rate
Loans
	  	 Applicable

Margin for
 LIBOR
Rate
 Loans
	  	
Applicable

Unutilized
 Commitment
Fee
 Margin

	
I
	  	Less than or equal to 1/3 of the Maximum Credit	  	1.50%	  	2.50%	  	0.25%

  
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II
	  	Greater than 1/3 of the Maximum Credit, but less than or equal to 2/3 of the Maximum Credit	  	1.25%	  	2.25%	  	0.375%
	
III
	  	Greater than 2/3 of the Maximum Credit	  	1.00%	  	2.00%	  	0.50%

 (b) The definition of “Applicable Margin” in Section 1.2 of the Loan Agreement is hereby
amended by deleting clause (b) thereof in its entirety and replacing it with the following: 
 “(b) For the period from and
including the Amendment No. 4 Effective Date to but excluding the First Adjustment Date (as defined below), the Applicable Margin shall be 1.75% for Base Rate Loans and 2.75% for LIBOR Rate Loans, and the Unutilized Commitment Fee shall be
0.50%. After the Amendment No. 4 Effective Date, (i) on the first (1st) day of any calendar quarter (i.e., the first
(1st) day of July, September, January or April) after which the Administrative Borrower shall have delivered a Compliance Certificate to Agent pursuant to Section 9.7 or 9.8 of this
Agreement, demonstrating a Fixed Charge Coverage Ratio of not less than 1.00:1.00 for the trailing twelve (12) month period then ended (the “First Adjustment Date”), and (ii) thereafter, on the first (1st) day of each calendar quarter (i.e., the first (1st) day of each of July, September, January, and April) (each an
“Adjustment Date”), the Applicable Margin for each type of Advance and the Unutilized Commitment Fee shall be adjusted based upon the Borrowing Base Certificates delivered to Agent, in accordance with Section 9.2(c), with
respect to the months comprising the immediately preceding calendar quarter and based upon the calculation by Agent of Quarterly Average Undrawn Availability for such calendar quarter. After the First Adjustment Date, in the event that any Borrowing
Base Certificate is not provided to the Agent in accordance with Section 9.2(c), the Applicable Margin for each type of Advance and the Unutilized Commitment Fee for the applicable calendar quarter shall be set at the Applicable Margin for such
type of Advance and for the Unutilized Commitment Fee set forth in Level I above as of the first (1st) day of the calendar quarter following the month in which such Borrowing Base Certificate
was required to be delivered and shall continue at Level I for such entire calendar quarter and thereafter until the next Adjustment Date, if any.” 

(c) The definition of “BA Rate” in Section 1.2 of the Loan Agreement is hereby amended by inserting the following sentence at
the end thereof: 
  
 “Notwithstanding the foregoing, if at any time
the BA Rate shall be less than 0%, then the BA Rate shall be deemed to be 0%.” 

  
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 (d) The definition of “Canadian Revolving Loan Maximum Amount” in Section 1.2 of
the Loan Agreement is hereby amended by deleting such definition in its entirety and replacing it with the following: 
 “Canadian
Revolving Loan Maximum Amount” shall mean $16,000,000 (subject to adjustment as provided pursuant to the terms of Sections 2.20 and 2.21). 

(e) The definition of “LIBOR” in Section 1.2 of the Loan Agreement is hereby amended by inserting the following sentence at the
end thereof: 
 “Notwithstanding the foregoing, if at any time LIBOR shall be less than 0%, then LIBOR shall be deemed to be 0%.”

 (f) The definition of “Maximum Credit” in Section 1.2 of the Loan Agreement is hereby amended by deleting such definition
in its entirety and replacing it with the following: 
 “Maximum Credit” shall mean $100,000,000 (subject to adjustment as
provided pursuant to the terms of Section 2.20 and Section 2.21). 
 (g) The definition of “Maximum Swingline Advance
Amount” in Section 1.2 of the Loan Agreement is hereby amended by deleting such definition in its entirety and replacing it with the following: 

“Maximum Swingline Advance Amount” shall mean $10,000,000. 

(h) The definition of “Reserves” in Section 1.2 of the Loan Agreement is hereby amended by deleting the phrase “shall mean
such reserves as Agent may from time to time establish” and replacing it with “shall mean the sum of the Availability Block plus such other reserves as Agent may from time to time establish”. 

(i) The definition of “US Letter of Credit Limit” in Section 1.2 of the Loan Agreement is hereby amended by deleting such
definition in its entirety and replacing it with the following: 
 “US Letter of Credit Limit” shall mean, on any date of
determination, $16,000,000, minus the amount of all then outstanding Canadian Letter of Credit Obligations. 
 5. Other Amendments.

 (a) Section 2.8 of the Loan Agreement is hereby amended by deleting each reference to “$20,000,000” where it appears in
clauses (a) and (b) of such section and replacing it with “$16,000,000”. 
 (b) Schedule C-1 to the Loan Agreement is
hereby amended and restated in its entirety as set forth on Exhibit A attached hereto. 

  
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 6. Amendment Fee. The Borrowers shall pay to the Agent, for the ratable benefit of each
Lender (based on the Commitment of each Lender immediately after giving effect to this Amendment No. 4) which executes this Amendment No. 4 by no later than June 24, 2016, an amendment fee, which fee shall be fully earned on the
Amendment No. 4 Effective Date, non-refundable in all circumstances, and payable as follows: 
 (a) an amount equal to
$350,000 shall be due and payable on or prior to the Amendment No. 4 Effective Date; and 
 (b) an amount equal to
$275,000 shall be due and payable on the earlier of (i) October 31, 2016 and (ii) the first date on which any Senior Secured Notes or any Non-Exchanged Notes are prepaid as contemplated by Section 2 above. 

7. Conditions to Effectiveness. This Amendment No. 4 shall not be effective until each of the following conditions precedent is
satisfied in a manner reasonably satisfactory to Agent and Lenders: 
 (a) the receipt by Agent of an original of this
Amendment No. 4 (or an executed copy delivered by facsimile or other electronic transmission), duly authorized, executed and delivered by Borrowers, Guarantors and the Required Lenders; 

(b) the receipt by Agent of the fees described in Section 6(a) above; and 

(c) no Default or Event of Default has occurred and is continuing. 

8. Representations and Warranties of Borrowers and Guarantors. Each Borrower and Guarantor hereby represents, warrants and covenants
with and in favor of Agent and Lenders as of the date hereof the following (which shall survive the execution and delivery of this Amendment No. 4): 

(a) No consent, approval or other action of, or filing with, or notice to any Governmental Body is required in connection with
the execution, delivery and performance of this Amendment No. 4, any of the other Amendment Documents (as defined below) or any of the transactions contemplated hereby; 

(b) This Amendment No. 4, each agreement, document or instrument entered into by a Borrower or Guarantor in connection
herewith (collectively, with this Amendment No. 4, the “Amendment Documents”) and the transactions contemplated hereby have been duly authorized, executed and delivered by all necessary action on the part of each Borrower and
Guarantor which is a party hereto or thereto and, if necessary, their respective stockholders or other holders of their Equity Interests (as applicable), and is in full force and effect as of the date hereof, and the agreements and obligations of
the each Borrower and Guarantor contained herein or therein constitute the legal, valid and binding obligations of such Borrower and such Guarantor, enforceable against them in accordance with their respective terms, except as such enforceability
may be limited by any applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights generally and by general principles of equity; 

  
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 (c) Without limiting the foregoing, the execution, delivery and performance of
this Amendment No. 4 and the other Amendment Documents by the Borrowers and the Guarantor, and the transactions contemplated hereby, are authorized by the directors’ resolutions, copies of which are attached to the secretary’s
certificates, dated on or about February 3, 2016, delivered by each of the Borrowers and the Guarantor, and such directors’ resolutions have not in any way been modified, amended, repealed or rescinded, and are in full force and effect as
of the date hereof; 
 (d) The execution, delivery and performance of the Amendment Documents by each Borrower or Guarantor
party thereto and the transactions contemplated hereby (i) are all within such Borrower’s and Guarantor’s corporate or limited liability company powers, and (ii) are not in contravention of law or the terms of such
Borrower’s and such Guarantor’s certificate of incorporation, by-laws, or other organizational documentation, or any indenture, agreement or undertaking to which such Borrower or such Guarantor is a party or by which such Borrower or such
Guarantor or its property are bound; 
 (e) After giving effect to this Amendment No. 4, all of the representations and
warranties set forth in the Loan Agreement and the Other Documents to which Borrowers and Guarantors are a party are true and correct on and as of the date hereof as if made on the date hereof, except to the extent any such representation or
warranty is made as of a specified date, in which case such representation or warranty shall have been true and correct as of such date; and 

(f) After giving effect to the terms of this Amendment No. 4, no Default or Event of Default has occurred and is
continuing. 
 9. Reference to and Effect on the Loan Agreement. This Amendment No. 4, together with the other Amendment
Documents, constitute the entire agreement of the parties with respect to the subject matter hereof and thereof, and supersedes all prior oral or written communications, memoranda, proposals, negotiations, discussions, term sheets and commitments
with respect to the subject matter hereof. Except as expressly amended pursuant hereto or thereto, no other amendments, modifications or waivers to the Loan Agreement and the Other Documents are intended or implied, and in all other respects the
Loan Agreement and the Other Documents are hereby specifically ratified, restated and confirmed by all parties hereto as of the date hereof. To the extent that any provisions of the Loan Agreement or any of the Other Documents are inconsistent with
any provisions of this Amendment No. 4, the provisions of this Amendment No. 4 shall control. 
 10. Governing Law. This
Amendment No. 4 shall be governed by and construed in accordance with the laws of the State of New York, but excluding any principles of conflict of laws or other rule of law that would cause the application of the law of any jurisdiction other
than the laws of the State of New York. 

  
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 11. Counterparts. This Amendment No. 4 may be executed in any number of counterparts,
but all of such counterparts shall together constitute but one and the same agreement. In making proof of this Amendment No. 4, it shall not be necessary to produce or account for more than one counterpart thereof signed by each of the parties
hereto. Delivery of an executed counterpart of this Amendment No. 4 by telecopier or electronically shall have the same force and effect as delivery of an original executed counterpart of this Amendment No. 4. Any party delivering an
executed counterpart of this Amendment No. 4 by telecopier or electronically also shall deliver an original executed counterpart of this Amendment No. 4, but the failure to deliver an original executed counterpart shall not affect the
validity, enforceability, and binding effect of this Amendment No. 4 as to such party or any other party. 
 [Signature Pages to Follow]

  
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 IN WITNESS WHEREOF, each of the parties has signed this Amendment No. 4 as of the day and
year first above written. 
  

			
	BORROWERS:
	
	A.M. CASTLE & CO.
		
	By:	 	/s/ Patrick R. Anderson
	Name: 	 	Patrick R. Anderson
	Title:	 	Chief Financial Officer
	
	TOTAL PLASTICS, INC.
		
	By:	 	/s/ Patrick R. Anderson
	Name:	 	Patrick R. Anderson
	Title:	 	Vice President
	
	A.M. CASTLE & CO. (CANADA) INC.
		
	By:	 	/s/ Patrick R. Anderson
	Name:	 	Patrick R. Anderson
	Title:	 	 Vice President – Finance, Chief Financial

Officer and Treasurer

  
 [Signature Page to Amendment
No. 4 to LSA] 
  

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	GUARANTORS:
	
	KEYSTONE TUBE COMPANY, LLC
		
	By:	 	/s/ Patrick R. Anderson
	Name: 	 	Patrick R. Anderson
	Title:	 	Treasurer

  
 [Signature Page to Amendment
No. 4 to LSA] 

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	AGENT AND LENDERS:
	
	 WELLS FARGO BANK, NATIONAL

ASSOCIATION,
 as Agent, Swingline Lender, Issuing Bank and
a
 Lender

		
	By:	 	/s/ David Wisniewski
	Name: 	 	David Wisniewski
	Title:	 	Assistant Vice President

  
 [Signature Page to Amendment
No. 4 to LSA] 

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	LENDERS:
	
	 WELLS FARGO CAPITAL FINANCE

CORPORATION CANADA,
 as a Lender

		
	By:	 	/s/Raymond Eghobamien
	Name: 	 	Raymond Eghobamien
	Title:	 	Vice President

  
 [Signature Page to Amendment
No. 4 to LSA] 

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	LENDERS:
	
	 BANK OF AMERICA, N.A.,
 as a
Lender

		
	By:	 	/s/ Thomas H. Herron
	Name: 	 	Thomas H. Herron
	Title:	 	Senior Vice President

  
 [Signature Page to Amendment
No. 4 to LSA] 

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	LENDERS:
	
	 BANK OF AMERICA, N.A., ACTING

THROUGH ITS CANADA BRANCH,
 as a Lender

		
	By:	 	/s/ Sylwia Durkiewicz
	Name: 	 	Sylwia Durkiewicz
	Title:	 	Vice President

  
 [Signature Page to Amendment
No. 4 to LSA] 

 [AMENDMENT SIGNATURES CONTINUED FROM PREVIOUS PAGE] 

 

			
	LENDERS:
	
	 REGIONS BANK,
 as a
Lender

		
	By:	 	/s/ Darius Sutvinaitis
	Name: 	 	Darius Sutvinaitis
	Title:	 	Vice President

  
 [Signature Page to Amendment
No. 4 to LSA]Stock Purchase Agreement

 Exhibit 10.1 

EXECUTION VERSION 

ORAGENICS, INC. 
 STOCK
PURCHASE AGREEMENT 
 This Stock Purchase Agreement (this “Agreement”) is made and entered into as of
June 30, 2016 (the “Effective Date”), among Oragenics, Inc., a Florida corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a
“Purchaser” and collectively the “Purchasers”). 
 RECITALS 

A. The Company and each Purchaser is executing and delivering this Agreement in reliance upon the exemption from securities registration
afforded by Section 4(2) of the Securities Act, and Rule 506 of Regulation D (“Regulation D”) as promulgated by the United States Securities and Exchange Commission (the “Commission”) under the Securities Act.

 B. Each Purchaser, severally and not jointly, wishes to purchase, and the Company wishes to sell, upon the terms and conditions stated in
this Agreement, that aggregate number of shares of Common Stock set forth below such Purchaser’s name on the signature page of this Agreement. 

AGREEMENT 
 NOW,
THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt and adequacy of which are hereby acknowledged, the Company and each Purchaser agree as follows:

 ARTICLE I 

DEFINITIONS 

1.1 Definitions. In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the
following terms have the meanings set forth in this Section 1.1: 
 “Affiliate” means any Person that, directly or
indirectly through one or more intermediaries, controls or is controlled by or is under common control with a Person as such terms are used in and construed under Rule 144 under the Securities Act. With respect to a Purchaser, any investment fund or
managed account that is managed on a discretionary basis by the same investment manager as such Purchaser will be deemed to be an Affiliate of such Purchaser. 

“Business Day” means any day except Saturday, Sunday, any day which shall be a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to close. 

  
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 “Closing” means the closing of the purchase and sale of the Securities pursuant
to Section 2.1. 
 “Closing Date” means the date and time of the Closing. 

“Commission” means the Securities and Exchange Commission. 

“Common Stock” means the Common Stock of the Company, par value $0.001 per share, and any other class of securities into
which such securities may hereafter be reclassified or changed into. 
 “Common Stock Equivalents” means any securities of
the Company or the Subsidiaries which would entitle the holder thereof to acquire at any time Common Stock, including, without limitation, any debt, preferred stock, rights, options, warrants or other instrument that is at any time convertible into
or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock. 
 “Disclosure
Schedules” means the Disclosure Schedules of the Company, if any, delivered concurrently herewith. 
 “Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder. 

“GAAP” shall have the meaning ascribed to such term in Section 3.1(e). 

“Intellectual Property” shall have the meaning ascribed to such term in Section 3.1(o). 

“Legend Removal Date” shall have the meaning ascribed to such term in Section 4.1(c). 

“Liens” means a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.

 “Material Adverse Effect” shall have the meaning assigned to such term in Section 3.1(a). 

“Per Share Purchase Price” means the price per Share to be purchased that shall be based on the Closing Price of the Common
Stock on the Trading Market on the date prior to the Closing Date which date prior is June 29, 2016 and which price per Share equals $0.5159. 

“Person” means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture,
limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind. 

“Proceeding” means an action, claim, suit, investigation or proceeding (including, without limitation, an investigation or
partial proceeding, such as a deposition), whether commenced or threatened. 

  
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 “Promissory Note” means the unsecured promissory note from the Koski Family
Limited Partnership in the principal amount of $2,000,000 delivered to the Company in connection with its purchase of the Shares. 

“Purchaser Party” shall have the meaning ascribed to such term in Section 4.5. 

“Rule 144” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time
to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule. 

“SEC Documents” shall have the meaning ascribed to such term in Section 3.1(e). 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

“Shares” means the shares of Common Stock issued or issuable to each Purchaser pursuant to this Agreement. 

“Short Sales” include, without limitation, all “short sales” as defined in Rule 200 promulgated under Regulation
SHO under the Exchange Act, whether or not against the box, and all types of direct and indirect stock pledges, forward sale contracts, options, puts, calls, short sales, swaps, “put equivalent positions” (as defined in Rule 16a-1(h) under
the Exchange Act) and similar arrangements (including on a total return basis), and sales and other transactions through non-U.S. broker dealers or foreign regulated brokers. 

“Subsidiary” means any subsidiary of the Company as set forth in the SEC Documents. 

“Subscription Amount” means, as to each Purchaser, the aggregate amount to be paid for the Shares purchased hereunder as
specified below such Purchaser’s name on Exhibit A of this Agreement and next to the heading “Subscription Amount” which aggregate amount shall equal the number of Shares purchased by such Purchaser multiplied by the Per Share
Purchase Price rounded to the nearest whole number of shares. 
 “Trading Day” means a day on which the Common Stock is
traded on a Trading Market. 
 “Trading Market” means the NYSE-MKT. 

“Transaction Documents” means this Agreement, the Promissory Note and any other documents or agreements executed in
connection with the transactions contemplated hereunder. 
 “Transfer Agent” means Continental Stock Transfer and Trust
Company, and any successor transfer agent of the Company. 

  
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 ARTICLE II 

PURCHASE AND SALE 
 2.1
Closing. Upon the terms and subject to the conditions set forth herein, the Company agrees to sell, and the Purchasers, severally and not jointly, agree to purchase, up to purchase the Shares set forth on Exhibit A. On the Closing Date, each
Purchaser shall deliver to the Company immediately available funds via wire transfer for such Purchaser’s Subscription Amount as set forth on Exhibit A and the Koski Family Limited Partnership shall deliver the Promissory Note to the Company.

 2.2 Closing; Delivery. 

(a) The purchase and sale of the Shares shall take place remotely via the exchange of documents and signatures, on the date of execution of
this Agreement or at such other time and place as the Company and the Purchasers mutually agree upon, orally or in writing (the “Closing”). 

(b) At the Closing, the Company shall deliver to each Purchaser: 

(i) this Agreement duly executed by the Company; 

(ii) executed written consent of the Board of Directors; 

(iii) a copy of the irrevocable instructions to the Transfer Agent substantially in the form of instructing the Transfer Agent to deliver, on
an expedited basis, one or more stock certificates evidencing such number of Shares as are being delivered on the Closing Date registered in the names of such Purchasers; 

(iv) approval by the Trading Market of an additional listing application covering all of the Shares to be delivered on such Closing Date. 

(c) At the Closing, each Purchase shall deliver to the Company: 

(i) this Agreement duly executed by the Company; 

(ii) such Purchaser’s Subscription Amount. 

ARTICLE III 

REPRESENTATIONS AND WARRANTIES 

3.1 Representations and Warranties of the Company. Except as set forth in the SEC Documents and Disclosure Schedules which Disclosure
Schedules shall be deemed a part hereof and shall qualify any representation or otherwise made herein to the extent of the disclosure contained in the corresponding Section of the Disclosure Schedules, the Company hereby makes the following
representations and warranties to each Purchaser as of the Closing Date: 

  
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 (a) Organization, Good Standing and Power. The Company is a corporation duly
incorporated, validly existing and in good standing under the laws of the State of Florida and has the requisite corporate power to own, lease and operate its properties and assets and to conduct its business as it is now being conducted and as
described in the reports filed by the Company with the Commission pursuant to the reporting requirements of the Exchange Act, since the end of its most recently completed fiscal year through the date hereof, including, without limitation, its most
recent report on Form 10-Q. The Company does not have any material subsidiaries. The Company is qualified to do business as a foreign corporation and is in good standing in every jurisdiction in which the nature of the business conducted or property
owned by it makes such qualification necessary, except for any jurisdiction(s) (alone or in the aggregate) in which the failure to be so qualified will not have a Material Adverse Effect. For the purposes of this Agreement, “Material Adverse
Effect” means any effect on the business, operations, properties or financial condition of the Company that is material and adverse to the Company, taken as a whole, and any condition, circumstance or situation that would prohibit the
Company from entering into and performing any of its obligations hereunder. 
 (b) Authorization; Enforcement. The Company has the
requisite corporate power and authority to enter into and perform the Transaction Documents and to issue the Shares in accordance with the terms hereof. The execution, delivery and performance of the Transaction Documents by the Company and the
consummation by it of the transactions contemplated hereby have been duly and validly authorized by all necessary corporate action, and no further consent or authorization of the Company, its board of directors or stockholders is required. When
executed and delivered by the Company, the Transaction Documents shall constitute a valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except as such enforceability may be limited by applicable
bankruptcy, reorganization, moratorium, liquidation, conservatorship, receivership or similar laws relating to, or affecting generally the enforcement of, creditor’s rights and remedies or by other equitable principles of general application.

 (c) Issuance of Shares. The Shares to be issued and sold hereunder have been duly authorized by all necessary corporate action and,
when issued in accordance with the terms hereof, will be validly issued, fully paid and nonassessable. In addition, such Shares will be free and clear of all liens, claims, charges, security interests or agreements, pledges, assignments, covenants,
restrictions or other encumbrances created by, or imposed by, the Company (collectively, “Encumbrances”) and rights of refusal of any kind imposed by the Company (other than restrictions on transfer under applicable securities laws)
and the holder of such shares shall be entitled to all rights accorded to a holder of Common Stock. As of March 31, 2016, 40,058,540 shares of the Company’s Common Stock are issued and outstanding and no shares of preferred stock are
outstanding. As of March 31, 2016, the Company had options outstanding to acquire 2,277,462 shares of Common Stock and warrants outstanding to acquire 175,584 shares of Common Stock. 

(d) No Conflicts; Governmental Approvals. The execution, delivery and performance of the Transaction Documents by the Company and the
consummation by the Company of the transactions contemplated hereby do not and will not (i) violate any provision of the Company’s Articles of Incorporation or Bylaws, each as amended to date, (ii) conflict with,

  
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or constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation
of, any agreement, mortgage, deed of trust, indenture, note, bond, license, lease agreement, instrument or obligation to which the Company is a party or by which the Company’s properties or assets are bound, or (iii) result in a violation
of any federal, state, local or foreign statute, rule, regulation, order, judgment or decree (including federal and state securities laws and regulations) applicable to the Company or by which any property or asset of the Company is bound or
affected, except for such conflicts, defaults, terminations, amendments, acceleration, cancellations and violations as would not, individually or in the aggregate, have a Material Adverse Effect. The Company is not required under federal, state,
foreign or local law, rule or regulation to obtain any consent, authorization or order of, or make any filing or registration with, any court or governmental agency in order for it to execute, deliver or perform any of its obligations under this
Agreement or issue and sell the shares in accordance with the terms hereof (other than any filings, consents and approvals which may be required to be made by the Company under applicable state and federal securities laws, rules or regulations prior
to or subsequent to the Closing). 
 (e) Commission Documents, Financial Statements. The Common Stock of the Company is registered
pursuant to Section 12(g) of the Exchange Act. During the year preceding this Agreement, the Company has timely filed all reports, schedules, forms, statements and other documents required to be filed by it with the Commission pursuant to the
reporting requirements of the Exchange Act (the foregoing materials, including the exhibits thereto and documents incorporated by reference therein being collectively referred to as the “SEC Documents”). At the times of their
respective filing, all such reports, schedules, forms, statements and other documents complied in all material respects with the requirements of the Exchange Act and the rules and regulations of the Commission promulgated thereunder. At the times of
their respective filings, such reports, schedules, forms, statements and other documents did not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the
statements therein, in light of the circumstances under which they were made, not misleading. As of their respective dates, the financial statements of the Company included in the SEC Documents complied in all material respects with applicable
accounting requirements and the published rules and regulations of the Commission or other applicable rules and regulations with respect thereto. Such financial statements have been prepared in accordance with United States generally accepted
accounting principles applied on a consistent basis (“GAAP”) during the periods involved (except (i) as may be otherwise indicated in such financial statements or the notes thereto or (ii) in the case of unaudited interim
statements, to the extent they may not include footnotes or may be condensed or summary statements), and fairly present in all material respects the consolidated financial position of the Company as of the dates thereof and the results of operations
and cash flows for the periods then ended (subject, in the case of unaudited statements, to normal year-end audit adjustments). 
 (f)
Accountants. Mayer Hoffman McCann P.C. whose report on the financial statements of the Company is filed with the Commission in the Company’s Annual Report on Form 10-K for the year ended December 31, 2015, were, at the time such
report was issued, independent registered public accountants as required by the Securities Act. 

  
 6 

 (g) Internal Controls. The Company has established and maintains a system of internal
accounting controls sufficient to provide reasonable assurances that: (i) transactions are executed in accordance with management’s general or specific authorization; (ii) transactions are recorded as necessary to permit preparation
of financial statements in conformity with generally accepted accounting principles in the United States and to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management’s general or
specific authorization; and (iv) the recorded accountability for assets is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any differences. 

(h) Disclosure Controls. The Company has established and maintains disclosure controls and procedures (as such term is defined in Rules 13a-15 and 15d-15 under the Exchange Act). Since the date of the most recent evaluation of such disclosure controls and procedures, there have been no significant changes in internal controls or in other factors
that could significantly affect internal controls, including any corrective actions with regard to significant deficiencies and material weaknesses. The Company is in compliance in all material respects with all provisions currently in effect and
applicable to the Company of the Sarbanes-Oxley Act of 2002, and all rules and regulations promulgated thereunder or implementing the provisions thereof. 

(i) No Material Adverse Change. Except as disclosed in the SEC Documents, since March 31, 2016, the Company has not
(i) experienced or suffered any Material Adverse Effect, (ii) incurred any material liabilities, obligations, claims or losses (whether liquidated or unliquidated, secured or unsecured, absolute, accrued, contingent or otherwise) other
than those incurred in the ordinary course of the Company’s business or (iii) declared, made or paid any dividend or distribution of any kind on its capital stock. 

(j) No Undisclosed Events or Circumstances. Except as disclosed in the SEC Documents, and except for the consummation of the
transactions contemplated herein, since March 31, 2016, to the Company’s knowledge, no event or circumstance has occurred or exists with respect to the Company or its businesses, properties, prospects, operations or financial condition,
which, under applicable law, rule or regulation, requires public disclosure or announcement by the Company but which has not been so publicly announced or disclosed. 

(k) Litigation. No action, suit, proceeding or investigation is currently pending or, to the knowledge of the Company, has been
threatened in writing against the Company that: (i) concerns or questions the validity of this Agreement; (ii) concerns or questions the right of the Company to enter into this Agreement; or (iii) is reasonably likely to have a
Material Adverse Effect. The Company is neither a party to nor subject to the provisions of any material order, writ, injunction, judgment or decree of any court or government agency or instrumentality. There is no action, suit, proceeding or
investigation by the Company currently pending or that the Company intends to initiate that would have a Material Adverse Effect. 
 (l)
Compliance. Except for defaults or violations which are not reasonably likely to have a Material Adverse Effect, the Company is not (i) in default under or in violation of (and no event has occurred that has not been waived that, with
notice or lapse of time or both, would result in a default by the Company under), nor has the Company received notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreement

  
 7 

 
or any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation
of any order of any court, arbitrator or governmental body, or (iii) is or has been in violation of any statute, rule or regulation of any governmental authority, including without limitation all foreign, federal, state and local laws,
applicable to its business. 
 (m) Intellectual Property 

(a) To the best of its knowledge, the Company has entered into agreements with each of its current and former officers, employees and
consultants involved in research and development work, including development of the Company’s products and technology providing the Company, to the extent permitted by law, with title and ownership to patents, patent applications, trade secrets
and inventions conceived, developed, reduced to practice by such person, solely or jointly with other of such persons, during the period of employment by the Company except where the failure to have entered into such an agreement would not have a
Material Adverse Effect. The Company is not aware that any of its employees or consultants is in material violation thereof. 
 (b)
To the Company’s knowledge, the Company owns or possesses adequate rights to use all trademarks, service marks, trade names, domain names, copyrights, patents, patent applications, inventions, know how (including trade secrets and other
unpatented and/or unpatentable proprietary or confidential information, systems or procedures), and other intellectual property rights (“Intellectual Property”) as are necessary for the conduct of its business as described in the
Commission Documents. Except as described in the SEC Documents, (i) to the knowledge of the Company, there is no infringement, misappropriation or violation by third parties of any such Intellectual Property; (ii) there is no pending or,
to the knowledge of the Company, threatened action, suit, proceeding or claim by others against the Company challenging the Company’s rights in or to any such Intellectual Property; (iii) the Intellectual Property owned by the Company and,
to the knowledge of the Company, the Intellectual Property licensed to the Company has not been adjudged invalid or unenforceable by a court of competent jurisdiction or applicable government agency, in whole or in part, and there is no pending or,
to the knowledge of the Company, threatened action, suit, proceeding or claim by others challenging the validity or scope of any such Intellectual Property; (iv) there is no pending or, to the knowledge of the Company, threatened action, suit,
proceeding or claim by others against the Company that the Company infringes, misappropriates or otherwise violates any Intellectual Property or other proprietary rights of others, and the Company has not received any written notice of such claim;
and (v) to the Company’s knowledge, no employee of the Company is the subject of any claim or proceeding involving a violation of any term of any employment contract, patent disclosure agreement, invention assignment agreement,
non-competition agreement, non-solicitation agreement, nondisclosure agreement or any restrictive covenant to or with a former employer where the basis of such violation relates to such employee’s employment with the Company or actions
undertaken by the employee while employed with the Company, in each of (i) through (v), for any instances which would not, individually or in the aggregate, result in a Material Adverse Effect.  

  
 8 

 (n) FDA Compliance. 

(a) Except as described in the SEC Documents, the Company: (i) is in material compliance with all statutes, rules or regulations
applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution, marketing, labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product that is under development,
manufactured or distributed by the Company (“Applicable Laws”); (ii) has not received any FDA Form 483, notice of adverse finding, warning letter, untitled letter or other correspondence or notice from the U.S. Food and Drug
Administration (the “FDA”) or any other federal, state, local or foreign governmental or regulatory authority alleging or asserting material noncompliance with any Applicable Laws or any licenses, certificates, approvals,
clearances, authorizations, permits and supplements or amendments thereto required by any such Applicable Laws (“Authorizations”), which would not, individually or in the aggregate, result in a Material Adverse Effect;
(iii) possesses all material Authorizations necessary for the operation of its business as described in the SEC Documents and such Authorizations are valid and in full force and effect and the Company is not in material violation of any term of
any such Authorizations; and (iv) since January 1, 2016: (A) has not received notice of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from the FDA or any other federal, state,
local or foreign governmental or regulatory authority or third party alleging that any product operation or activity is in material violation of any Applicable Laws or Authorizations and has no knowledge that the FDA or any other federal, state,
local or foreign governmental or regulatory authority or third party is considering any such claim, litigation, arbitration, action, suit, investigation or proceeding; (B) has not received notice that the FDA or any other federal, state, local
or foreign governmental or regulatory authority has taken, is taking or intends to take action to limit, suspend, modify or revoke any material Authorizations and has no knowledge that the FDA or any other federal, state, local or foreign
governmental or regulatory authority is considering such action; (C) has filed, obtained, maintained or submitted all material reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as
required by any Applicable Laws or Authorizations and that all such reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments were materially complete and correct on the date filed (or were
corrected or supplemented by a subsequent submission); and (D) has not, either voluntarily or involuntarily, initiated, conducted, or issued or caused to be initiated, conducted or issued, any recall, market withdrawal or replacement, safety
alert, post sale warning, “dear doctor” letter, or other notice or action relating to the alleged lack of safety or efficacy of any product or any alleged product defect or violation and, to the Company’s knowledge, no third party has
initiated, conducted or intends to initiate any such notice or action. 
 (b) Since January 1, 2016, and except to the extent
disclosed in the SEC Documents, the Company has not received any notices or correspondence from the FDA or any other federal, state, local or foreign governmental or regulatory authority requiring the termination, suspension or material modification
of any studies, tests or preclinical or clinical trials conducted by or on behalf of the Company. 
 (o) General Healthcare Regulatory
Compliance. 
 (a) As used in this subsection: 

  
 9 

 (i) “Governmental Entity” means any national, federal, state, county,
municipal, local or foreign government, or any political subdivision, court, body, agency or regulatory authority thereof, and any Person exercising executive, legislative, judicial, regulatory, taxing or administrative functions of or pertaining to
any of the foregoing. 
 (ii) “Law” means any federal, state, local, national or foreign law, statute, code,
ordinance, rule, regulation, order, judgment, writ, stipulation, award, injunction, decree or arbitration award or finding. 
 (b) The
Company has not committed any act, made any statement or failed to make any statement that would reasonably be expected to provide a basis for the FDA or any other Governmental Entity to invoke its policy with respect to “Fraud, Untrue
Statements of Material Facts, Bribery, and Illegal Gratuities”, or similar policies, set forth in any applicable Laws. Neither the Company, nor, to the knowledge of the Company, any of its officers, key employees or agents has been convicted of
any crime or engaged in any conduct that has resulted, or would reasonably be expected to result, in debarment under applicable Law, including, without limitation, 21 U.S.C. Section 335a. No claims, actions, proceedings or investigations that
would reasonably be expected to result in such a material debarment or exclusion are pending, or to the knowledge of the Company, threatened, against the Company or any of its respective officers, employees or agents. 

(c) Each of the Company and, to its knowledge, its directors, officers, employees, and agents (while acting in such capacity) is, and
at all times has been, in material compliance with all health care Laws applicable to the Company or by which any of its properties, businesses, products or other assets is bound or affected, including, without limitation, the federal Anti-kickback
Statute (42 U.S.C. § 1320a-7b(b)), the Anti-Inducement Law (42 U.S.C. § 1320a-7a(a)(5)), the civil False Claims Act (31 U.S.C. §§ 3729 et seq.), the administrative False Claims Law (42 U.S.C. § 1320a-7b(a)), the Health
Insurance Portability and Accountability Act of 1996 (42 U.S.C. § 1320d et seq.), the exclusion laws (42 U.S.C. § 1320a-7), the Food Drug and Cosmetic Act (21 U.S.C. §§ 301 et seq.) (collectively, “Health Care
Laws”). The Company has not received any notification, correspondence or any other written or oral communication from any Governmental Entity, including, without limitation, the FDA, the Centers for Medicare and Medicaid Services, and the
Department of Health and Human Services Office of Inspector General, of potential or actual material non-compliance by, or liability of, the Company under any Health Care Laws. 

(d) The Company is not a party to any corporate integrity agreements, monitoring agreements, consent decrees, settlement orders, or similar
agreements with or imposed by any Governmental Entity. 
 (p) Application of Takeover Protections. The issuance of the Shares
hereunder and the Purchasers’ ownership thereof is not prohibited by the business combination statutes of the state of Florida. The Company has not adopted any stockholder rights plan, “poison pill” or similar arrangement that would
trigger any right, obligation or event as a result of the issuance of such Shares and the Purchasers’ ownership of such shares and there are no similar anti-takeover provisions under the Company’s charter documents. 

  
 10 

 (q) Listing and Maintenance Requirements. The Company is in compliance with the
requirements of the Trading Market for continued listing of the Common Stock pursuant thereto. The issuance and sale of the shares hereunder does not contravene the rules and regulations of the Trading Market. 

(r) Private Placement. Neither the Company nor its Affiliates, nor any Person acting on its or their behalf, (i) has engaged in any
form of general solicitation or general advertising (within the meaning of Regulation D under the Securities Act) in connection with the offer or sale of the Shares hereunder, (ii) has, directly or indirectly, made any offers or sales of any
security or solicited any offers to buy any security, under any circumstances that would require registration of the sale and issuance by the Company of the Shares under the Securities Act or (iii) has issued any shares of Common Stock or
shares of any series of preferred stock or other securities or instruments convertible into, exchangeable for or otherwise entitling the holder thereof to acquire shares of Common Stock which would be integrated with the sale of the shares to
Purchasers for purposes of the Securities Act or of any applicable stockholder approval provisions, including, without limitation, under the rules and regulations of any exchange or automated quotation system on which any of the securities of the
Company are listed or designated, nor will the Company or any of its subsidiaries or affiliates take any action or steps that would require registration of any of the Shares under the Securities Act or cause the offering of the shares to be
integrated with other offerings. Assuming the accuracy of the representations and warranties of Purchasers, the offer and issuance of the Shares by the Company to Purchasers pursuant to this Agreement will be exempt from the registration
requirements of the Securities Act. 
 (s) No Manipulation of Stock. The Company has not taken, and has no plans to take, in violation
of applicable law, any action outside the ordinary course of business designed to, or that might reasonably be expected to, cause or result in unlawful manipulation of the price of the Common Stock. 

(t) Brokers. Neither the Company nor any of the officers, directors or employees of the Company has employed any broker or finder in
connection with the transaction contemplated by this Agreement. The Company shall indemnify Purchasers from and against any broker’s, finder’s or agent’s fees for which the Company is responsible. 

(u) Solvency. Based on the financial condition of the Company as of the Closing Date, after giving effect to the receipt by the Company
of the proceeds from the sale of the Shares hereunder and the conversion of the Company’s indebtedness to the KFLP, (i) the fair saleable value of the Company’s assets exceeds the amount that will be required to be paid on or in
respect of the Company’s existing debts and other liabilities (including known contingent liabilities) as they mature; (ii) the Company’s assets do not constitute unreasonably small capital to carry on its business as now conducted
and as proposed to be conducted including its capital needs taking into account the particular capital requirements of the business conducted by the Company, and projected capital requirements and capital availability thereof; and (iii) the
current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect of
its liabilities when such amounts are required to be paid. The Company does not intend to incur debts beyond its ability to pay such debts as they 

  
 11 

 
mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt). Assuming the Closing occurs, the Company has no knowledge of any facts or circumstances
which lead it to believe that it will file for reorganization or liquidation under the bankruptcy or reorganization laws of any jurisdiction within one year from the Closing Date. 

(v) Foreign Corrupt Practices. Neither the Company, nor to the knowledge of the Company, any agent or other person acting on behalf of
the Company, has (i) directly or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreign or
domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution made by the Company (or made by any person acting on its behalf of
which the Company is aware) which is in violation of law, or (iv) violated in any material respect any provision of the Foreign Corrupt Practices Act of 1977, as amended. 

3.2 Representations and Warranties of the Purchasers. Each Purchaser, for itself and for no other Purchaser, hereby represents and
warrants as of the Closing Date to the Company as follows: 
 (a) Authority. The execution, delivery and performance by such Purchaser
of the transactions contemplated by this Agreement have been duly authorized by all necessary corporate or similar action on the part of such Purchaser. Each Transaction Document to which it is a party has been duly executed by such Purchaser, and
when delivered by such Purchaser in accordance with the terms hereof, will constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance with its terms, except (i) as limited by general equitable
principles and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availability of specific
performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by applicable law. 

(b) Own Account. Such Purchaser understands that the Shares are “restricted securities” and have not been registered under the
Securities Act or any applicable state securities law and is acquiring the Shares as principal for its own account and not with a view to or for distributing or reselling such Shares or any part thereof in violation of the Securities Act or any
applicable state securities law, has no present intention of distributing any of such Shares in violation of the Securities Act or any applicable state securities law and has no direct or indirect arrangement or understandings with any other persons
to distribute or regarding the distribution of such Shares (this representation and warranty not limiting such Purchaser’s right to sell the Shares in compliance with applicable federal and state securities laws) in violation of the Securities
Act or any applicable state securities law. Such Purchaser is acquiring the Shares hereunder in the ordinary course of its business. Such Purchaser understands that it may not be able to sell any of the Shares without prior registration under the
Securities Act or the existence of an exemption from such registration requirement. 

  
 12 

 (c) No Conflicts. The execution, delivery and performance by such Purchaser of this
Agreement and the Promissory Note and the consummation by such Purchaser of the transactions contemplated hereby and thereby will not (i) result in a violation of the organizational documents of such Purchaser, (ii) conflict with, or
constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument to which such
Purchaser is a party, or (iii) result in a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws) applicable to such Purchaser, except in the case of clauses (ii) and
(iii) above, for such conflicts, defaults, rights or violations which would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the ability of such Purchaser to perform its obligations hereunder.

 (d) Purchaser Status. At the time such Purchaser was offered the Shares, it was, and at the date hereof is, an “accredited
investor” as defined in Rule 501 under the Securities Act. Such Purchaser is not a registered broker dealer registered under Section 15(a) of the Exchange Act, or a member of the Financial Industry Regulatory Authority Inc.
(“FINRA”), or an entity engaged in the business of being a broker-dealer. Neither such Purchaser, nor any of its officers or directors, is subject to any of the “Bad Actor” disqualifications described in Rule 506(d)(1)(i)
to (viii) under the Securities Act. 
 (e) Experience of Such Purchaser. Such Purchaser, either alone or together with its
representatives, has such knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Shares, and has so evaluated the merits and risks of
such investment. Such Purchaser is able to bear the economic risk of an investment in the Shares and, at the present time, is able to afford a complete loss of such investment. Such Purchaser acknowledges that it has not received any legal or tax
advice from the Company or any of its representatives with respect the transactions contemplated hereby. 
 (f) General Solicitation.
Such Purchaser is not purchasing the Shares as a result of any advertisement, article, notice or other communication regarding the Shares published in any newspaper, magazine or similar media or broadcast over television or radio or presented at any
seminar or any other general solicitation or general advertisement. 
 (g) Access to Information. Such Purchaser acknowledges that it
has had the opportunity to review any Company information and business updates requested by Purchaser and has been afforded (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, representatives of
the Company concerning the terms and conditions of the offering of the Shares and the merits and risks of investing in the Shares and; (ii) access to information about the Company and its financial condition, results of operations, business,
properties, management and prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense that is
necessary to make an informed investment decision with respect to the investment. Such Purchaser has sought such accounting, legal and tax advice as it has considered necessary to make an informed decision with respect to its acquisition of the
Shares. 

  
 13 

 (h) Certain Trading Activities. Other than with respect to the transactions contemplated
herein, since the time that such Purchaser was first contacted by the Company or any other Person regarding the transactions contemplated hereby, neither the Purchaser nor any Affiliate of such Purchaser which (x) had knowledge of the
transactions contemplated hereby, (y) has or shares discretion relating to such Purchaser’s investments or trading or information concerning such Purchaser’s investments, including in respect of the Shares, and (z) is subject to
such Purchaser’s review or input concerning such Affiliate’s investments or trading (collectively, “ Trading Affiliates”) has directly or indirectly, nor has any Person acting on behalf of or pursuant to any understanding with
such Purchaser or Trading Affiliate, effected or agreed to effect any purchases or sales of the securities of the Company (including, without limitation, any Short Sales involving the Company’s securities). Notwithstanding the foregoing, in the
case of a Purchaser and/or Trading Affiliate that is, individually or collectively, a multi-managed investment bank or vehicle whereby separate portfolio managers manage separate portions of such Purchaser’s or Trading Affiliate’s assets
and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of such Purchaser’s or Trading Affiliate’s assets, the representation set forth above shall apply only
with respect to the portion of assets managed by the portfolio manager that have knowledge about the financing transaction contemplated by this Agreement. Other than to other Persons party to this Agreement, such Purchaser has maintained the
confidentiality of all disclosures made to it in connection with this transaction (including the existence and terms of this transaction). 

(i) Brokers and Finders. No Person will have, as a result of the transactions contemplated by this Agreement, any valid right, interest
or claim against or upon the Company or any Purchaser for any commission, fee or other compensation pursuant to any agreement, arrangement or understanding entered into by or on behalf of the Purchaser. 

(j) Independent Investment Decision. Such Purchaser has independently evaluated the merits of its decision to purchase Shares pursuant
to the Transaction Documents, and such Purchaser confirms that it has not relied on the advice of any other Purchaser’s business and/or legal counsel in making such decision. Such Purchaser understands that nothing in this Agreement or any
other materials presented by or on behalf of the Company to the Purchaser in connection with the purchase of the Shares constitutes legal, tax or investment advice. Such Purchaser has consulted such legal, tax and investment advisors as it, in its
sole discretion, has deemed necessary or appropriate in connection with its purchase of the Shares. 
 (k) No Governmental Review.
Such Purchaser understands that no United States federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Shares or the fairness or suitability of the investment in the
Shares nor have such authorities passed upon or endorsed the merits of the offering of the Shares. 
 (l) Residency. Such
Purchaser’s residence (if an individual) or office in which its investment decision with respect to the Shares was made (if an entity) are located at the address immediately below such Purchaser’s name on its signature page hereto. 

  
 14 

 (m) Acknowledgment Each Purchaser acknowledges and agrees that such Purchaser has reviewed
and considered prior to entering this Agreement the more detailed information about the Company and the risk factors that may affect the realization of forward-looking statements set forth in the Company’s filings with the SEC, including its
Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q filed with the SEC. 
 (n) Waiver. Each Purchaser acknowledges and
agrees that such Purchaser has waived any and all participation rights, pre-emptive rights, rights of first refusal or any similar or other rights it may to purchase any of the Shares being purchased under this Agreement by any other Purchaser. 

The Company and each of the Purchasers acknowledge and agree that no party to this Agreement has made or makes any representations or
warranties with respect to the transactions contemplated hereby other than those specifically set forth in this Article III and the Transaction Documents. 

ARTICLE IV 
 OTHER
AGREEMENTS OF THE PARTIES 
 4.1 Transfer Restrictions. 

(a) The Shares may only be disposed of in compliance with state and federal securities laws, including the requirement not to trade in the
Shares while in possession of material non-public information. In connection with any transfer of Shares other than pursuant to an effective registration statement, to the Company or to an Affiliate of a Purchaser or in connection with a pledge as
contemplated in Section 4.1(b), the Company may require the transferor thereof to provide to the Company an opinion of counsel selected by the transferor and reasonably acceptable to the Company, the form and substance of which opinion shall be
reasonably satisfactory to the Company, to the effect that such transfer does not require registration of such transferred Shares under the Securities Act. As a condition of transfer, any such transferee shall agree in writing to be bound by the
terms of this Agreement and shall have the rights of a Purchaser under this Agreement. 
 (b) The Purchasers agree to the imprinting, so long
as is required by this Section 4.1, of a legend on any of the Shares in the following form: 
 THIS SECURITY HAS NOT BEEN REGISTERED
WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE
OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT 

  
 15 

 
SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH
EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT WITH A REGISTERED BROKER-DEALER OR OTHER LOAN WITH A FINANCIAL INSTITUTION THAT IS AN
“ACCREDITED INVESTOR” AS DEFINED IN RULE 501(a) UNDER THE SECURITIES ACT OR OTHER LOAN SECURED BY SUCH SECURITIES. 
 (c) The
Company acknowledges and agrees that a Purchaser may from time to time pledge pursuant to a bona fide margin agreement with a registered broker-dealer or grant a security interest in some or all of the Shares to a financial institution that is an
“accredited investor” as defined in Rule 501(a) under the Securities Act and who agrees to be bound by the provisions of this Agreement and, if required under the terms of such arrangement, such Purchaser may transfer pledged or secured
Shares to the pledgees or secured parties. Such a pledge or transfer would not be subject to approval of the Company and no legal opinion of legal counsel of the pledgee, secured party or pledgor shall be required in connection therewith. Further,
no notice shall be required of such pledge. 
 (d) Certificates evidencing the Shares shall not contain any legend (including the legend set
forth in Section 4.1(b)), (i) following any sale of such Shares pursuant to Rule 144, or (ii) if such Shares are eligible for sale under Rule 144, or (iii) if such legend is not required under applicable requirements of the
Securities Act (including judicial interpretations and pronouncements issued by the staff of the Commission). The Company shall cause its counsel to issue a legal opinion to the Transfer Agent promptly after the Effective Date if required by the
Transfer Agent to effect the removal of the legend hereunder. The Company agrees that following the Effective Date or at such time as such legend is no longer required under this Section 4.1(d), it will, no later than three Trading Days
following the delivery by a Purchaser to the Company or the Transfer Agent of a certificate representing Shares issued with a restrictive legend (such third Trading Day, the “Legend Removal Date”), deliver or cause to be delivered
to such Purchaser a certificate representing such shares that is free from all restrictive and other legends. The Company may not make any notation on its records or give instructions to the Transfer Agent that enlarge the restrictions on transfer
set forth in this Section. Certificates for Shares subject to legend removal hereunder shall be transmitted by the Transfer Agent to the Purchasers by crediting the account of the Purchaser’s prime broker with the Depository Trust Company
System, if the Transfer Agent is a participant in the DWAC system, and otherwise by physical delivery of certificates as directed by the Purchaser. 

(e) Each Purchaser, severally and not jointly with the other Purchasers, agrees that the removal of the restrictive legend from certificates
representing Shares as set forth in this Section 4.1 is predicated upon the Company’s reliance that the Purchaser will sell any Shares pursuant to either the registration requirements of the Securities Act, including any applicable
prospectus delivery requirements, or an exemption therefrom, and that if Shares are sold pursuant to a Registration Statement, they will be sold in compliance with the plan of distribution set forth therein. 

  
 16 

 4.2 Furnishing of Information. For a period of one year after the date of this Agreement,
the Company covenants to timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the Company after the date hereof pursuant to the Exchange Act. During this one-year
period, if the Company is not required to file reports pursuant to the Exchange Act, it will prepare and furnish to the Purchasers and make publicly available in accordance with Rule 144 such information as is required for the Purchasers to sell the
Shares under Rule 144. The Company further covenants that it will take such further action as any holder of Shares may reasonably request, to the extent required from time to time to enable such Person to sell such Shares without registration under
the Securities Act within the requirements of the exemption provided by Rule 144. 
 4.3 Integration. The Company shall not sell,
offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that could reasonably be expected to be integrated with the offer or sale of the Shares in a manner that
would require the registration under the Securities Act of the sale of the Shares to the Purchasers or that would be integrated with the offer or sale of the Shares for purposes of the rules and regulations of the Trading Market such that it would
require shareholder approval prior to the closing of such other transaction unless shareholder approval is obtained before the closing of such subsequent transaction. 

4.4 Securities Laws Disclosure; Publicity. On or before 9:00 a.m., New York City time, on the Business Day immediately following the
date hereof, the Company shall issue a press release (the “Press Release”) disclosing all material terms of the transactions contemplated hereby. On or before 5:30 p.m., New York City time, on the fourth Trading Day immediately
following the execution of this Agreement, the Company will file a Current Report on Form 8-K with the Commission describing the terms of the Transaction Documents (and including as exhibits to such Current Report on Form 8-K the material
Transaction Documents. Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser or an Affiliate of any Purchaser, or include the name of any Purchaser or an Affiliate of any Purchaser in any press release or
filing with the Commission (other than the Registration Statement) or any regulatory agency or Trading Market, without the prior written consent of such Purchaser, except (i) as required by federal securities law in connection with the filing
of final Transaction Documents (including signature pages thereto) with the Commission and (ii) to the extent such disclosure is required by law, request of the Staff of the Commission or Trading Market regulations, in which case the Company
shall provide the Purchasers with prior written notice of such disclosure permitted under this subclause (ii). From and after the issuance of the Press Release, no Purchaser shall be in possession of any material, non-public information received
from the Company or any of its officers, directors, employees or agents, that is not disclosed in the Press Release. Each Purchaser, severally and not jointly with the other Purchasers, covenants that it will comply with the provisions of any
confidentiality or nondisclosure agreement executed by it and, in addition, until such time as the transactions contemplated by this Agreement are required to be publicly disclosed by the Company as described in this Section 4.4, such Purchaser
will maintain the confidentiality of all disclosures made to it in connection with this transaction (including the existence and terms of this transaction). 

  
 17 

 4.5 Indemnification of Purchasers. 

(a) The Company will indemnify and hold each Purchaser and its directors, officers, stockholders, members, partners, employees and agents (and
any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls such Purchaser (within the meaning of Section 15 of the Securities Act and
Section 20 of the Exchange Act), and the directors, officers, stockholders, agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title
or any other title) of such controlling person (each, a “Purchaser Party”) harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all judgments, amounts paid in
settlements, court costs and reasonable attorneys’ fees and costs of investigation that any such Purchaser Party may suffer or incur as a result of any breach of any of the representations, warranties, covenants or agreements made by the
Company in this Agreement or in the other Transaction Documents. The Company will not be liable to any Purchaser Party under this Agreement to the extent, but only to the extent that a loss, claim, damage or liability is attributable to any
Purchaser Party’s breach of any of the representations, warranties, covenants or agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents; provided that such a claim for indemnification relating to any
breach of any of the representations or warranties made by the Company in this Agreement is made within one year from the Closing 
 (b)
Promptly after receipt by any Person (the “Indemnified Person”) of notice of any demand, claim or circumstances which would or might give rise to a claim or the commencement of any action, proceeding or investigation in respect of which
indemnity may be sought pursuant to Section 4.5(a), such Indemnified Person shall promptly notify the Company in writing and the Company shall assume the defense thereof, including the employment of counsel reasonably satisfactory to such
Indemnified Person, and shall assume the payment of all fees and expenses; provided, however, that the failure of any Indemnified Person so to notify the Company shall not relieve the Company of its obligations hereunder except to the extent that
the Company is actually and materially and adversely prejudiced by such failure to notify. In any such proceeding, any Indemnified Person shall have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the
expense of such Indemnified Person unless: (i) the Company and the Indemnified Person shall have mutually agreed to the retention of such counsel; (ii) the Company shall have failed promptly to assume the defense of such proceeding and to
employ counsel reasonably satisfactory to such Indemnified Person in such proceeding; or (iii) in the reasonable judgment of counsel to such Indemnified Person, representation of both parties by the same counsel would be inappropriate due to
actual or potential differing interests between them. The Company shall not be liable for any settlement of any proceeding effected without its written consent, which consent shall not be unreasonably withheld, delayed or conditioned. Without the
prior written consent of the Indemnified Person, which consent shall not be unreasonably withheld, delayed or conditioned, the Company shall not effect any settlement of any pending or threatened proceeding in respect of which any Indemnified Person
is or could have been a party and indemnity could have been sought hereunder by such Indemnified Party, unless such settlement includes an unconditional release of such Indemnified Person from all liability arising out of such proceeding. 

  
 18 

 4.6 Listing or Quotation of Common Stock. The Company’s common stock is currently
listed on the Trading Market. The Company will take all action reasonably necessary to continue the listing and trading of its Common Stock on a Trading Market and will comply in all respects with the Company’s reporting, filing and other
obligations under the bylaws or rules of the Trading Market. 
 4.7 Equal Treatment of Purchasers. No consideration shall be offered
or paid to any Person to amend or consent to a waiver or modification of any provision of any of the Transaction Documents unless the same consideration is also offered to all of the parties to the Transaction Documents. For clarification purposes,
this provision constitutes a separate right granted to each Purchaser by the Company and negotiated separately by each Purchaser, and is intended for the Company to treat the Purchasers as a class and shall not in any way be construed as the
Purchasers acting in concert or as a group with respect to the purchase, disposition or voting of Shares or otherwise. 
 4.8
Confidentiality After The Date Hereof. Each Purchaser, severally and not jointly with the other Purchasers, covenants that until such time as the transactions contemplated by this Agreement and such other material non-public information
related to the Company in possession of the Purchaser are publicly disclosed by the Company as described in Section 4.4, such Purchaser will maintain the confidentiality of all disclosures made to it in connection with this transaction
(including the existence and terms of this transaction). 
 4.9 Delivery of Shares After Closing. The Company shall deliver, or cause
to be delivered, the respective Shares purchased by each Purchaser to such Purchaser within three Trading Days of the Closing Date (unless such Purchaser has specified to the Company at the time of execution of this Agreement that it shall settle
“delivery versus payment” in which case such Shares shall be delivered on or prior to the Closing Date). 
 4.10 Form D; Blue
Sky Filings. The Company agrees to timely file a Form D with respect to the Shares as required under Regulation D and to provide a copy thereof, promptly upon request of any Purchaser. The Company shall take such action as the Company shall
reasonably determine is necessary in order to obtain an exemption for, or to qualify the Shares for, sale to the Purchasers at the Closing under applicable securities or “Blue Sky” laws of the states of the United States, and shall
provide evidence of such actions promptly upon request of any Purchaser. 
 4.12 Use of Proceeds. The Company intends to use the net
proceeds of this offering after payment of the expenses of the offering for the funding of: research and development activities related to the Intrexon Exclusive Channel Collaborations; and general corporate purposes and shall not use such proceeds
for the satisfaction of any portion of the Company’s debt (other than trade payables in the ordinary course of the Company’s business and prior practices), or to redeem any Common Stock or Common Stock Equivalents. 

  
 19 

 4.13 Registration Rights. 

(a) Piggyback Registration Rights. If, at any time, the Company proposes to file a registration statement under the Securities Act, other than
a registration relating solely to employee benefit plans or Rule 145 transactions, with respect to an underwritten offering for its own account of any class of securities of the Company (a “Registration Statement”), then each such time,
the Company shall give written notice of such intention to file a Registration Statement (a “Piggyback Notice”) to each Purchaser at least five (5) days before the anticipated filing date. The Piggyback Notice shall describe the
number of shares to be registered and the intended method of distribution and offer each Purchaser the opportunity to register pursuant to such Registration Statement such shares purchased under this Agreement and held by such Purchaser (the
“Registrable Shares”) as such Purchaser may request in writing to the Company within five (5) days after the date Investor first received the Piggyback Notice (a “Piggyback Registration”). The Piggyback Registration rights
shall be subject ratably to potential underwriter’s limitations set forth herein. The Company shall take all reasonable steps to include in the Registration Statement the Registrable Shares which the Company has been so requested to register by
such Purchaser. The Company shall be entitled to suspend or withdraw a Registration Statement prior to its becoming effective. If the managing underwriter with respect to such an offering advises the Company in writing that the inclusion of all or
any portion of the Registrable Shares which such Purchaser has requested to be included in the Registration Statement would materially jeopardize the success of the offering, then the Company shall be required to include in the underwriting only
that number of Registrable Shares which the underwriter advises the Company in writing may be sold without materially jeopardizing the offering which cutback shall be pro rata with any other Purchasers. If such Purchaser disapproves of the terms of
any such underwriting such Purchaser may elect to withdraw its Registrable Shares from it by written notice to the Company and the underwriter. Such Purchaser also agrees that it and Subsidiary shall be subject to any lock-up agreements reasonably
requested by a managing underwriter so long as the Company shares held by the Company’s largest shareholder are also subject to a similar lock-up agreement. The Company shall not grant registration rights to any other holder or prospective
holder of its securities in connection with a private placement of the Company’s securities unless, (i) all shares held by Purchaser by operation of this Agreement are, at the time of such private placement, included on a Registration
Statement, or (ii) the Company agrees, in connection with such private placement, to grant such Purchaser the right to include on the Registration Statement a collective total number of such Purchaser’s Registrable Shares equal to one half
of the number of shares to be registered on behalf of the other holder or prospective holder. 
 (b) Registration Expenses. All reasonable
fees and expenses incident to the performance of or compliance with this Agreement by the Company, except as and to the extent specified in this Section 4.13, shall be borne by the Company whether or not the Registration Statement is filed or
becomes effective and whether or not any shares are sold pursuant to the Registration Statement. The fees and expenses referred to in the foregoing sentence shall include, without limitation, (i) all registration and filing fees (including,
without limitation, fees and expenses (A) with respect to filings required to be made with each securities exchange or market on which shares are listed, (B) with respect to filings required to be made with the

  
 20 

 
Financial Industry Regulatory Authority and (C) in compliance with state securities or Blue Sky laws, (ii) messenger, telephone and delivery expenses, (iii) fees and disbursements
of counsel for the Company, (iv) Securities Act liability insurance, if the Company so desires such insurance, and (v) fees and expenses of all other persons or entities retained by the Company in connection with the consummation of the
transactions contemplated by this Section 4.13, including, without limitation, the Company’s independent public accountants. 
 (c)
Indemnification by the Company. The Company shall, notwithstanding any termination of this Agreement, indemnify and hold harmless each Purchaser, its permitted assignees, officers, directors, agents, affiliates and employees, to the fullest extent
permitted by applicable law, from and against any and all claims, losses, damages, liabilities, penalties, judgments, costs and expenses (including, without limitation, reasonable attorneys’ fees and expenses) (collectively,
“Losses”), arising out of or relating to any untrue or alleged untrue statement of a material fact contained in a Registration Statement or arising out of or relating to any omission or alleged omission of a material fact required to be
stated therein or necessary to make the statements therein (in the case of any prospectus or form of prospectus or supplement thereto, in the light of the circumstances under which they were made) not misleading, except (i) to the extent that
such untrue statements or omissions are based upon information furnished to the Company by such Purchaser expressly for use in the Registration Statement; (ii) as a result of the failure of such indemnitee to deliver a prospectus, as amended or
supplemented, to a purchaser in connection with an offer or sale; or (iii) the use by the indemnitee of an outdated or defective prospectus after the Company has notified such Purchaser in writing that the prospectus is outdated or defective,
but only if and to the extent that following such receipt the misstatement or omission giving rise to such Loss would have been corrected; provided, however, that the indemnity agreement contained in this Section 4.13(c) shall not apply to
amounts paid in settlement of any Losses if such settlement is effected without the prior written consent of the Company, which consent shall not be unreasonably withheld. 

(d) Indemnification by Purchaser. Each Purchaser shall severally and not jointly indemnify and hold harmless the Company, its directors,
officers, agents and employees to the fullest extent permitted by applicable law, from and against all Losses, as incurred, arising out of or relating to any untrue or alleged untrue statement of a material fact contained in a Registration Statement
or arising out of or relating to any omission or alleged omission of a material fact required to be stated therein or necessary to make the statements therein (in the case of any prospectus or supplement thereto, in the light of the circumstances
under which they were made) not misleading, to the extent that such untrue statement or omission is contained in or omitted from any information regarding Purchaser furnished in writing to the Company by such Purchaser expressly for use in therein,
and that such information was reasonably relied upon by the Company for use therein, or to the extent that such information relates to such Purchaser’s proposed method of distribution of shares and was furnished in writing by such Purchaser
expressly for use therein. Notwithstanding anything to the contrary contained herein, in no event shall the liability of such Purchaser under this Section 4.13(d) exceed the net proceeds to such Purchaser as a result of the sale of shares
pursuant to a Registration Statement in connection with which the untrue or alleged untrue statement or material omission was provided. 

  
 21 

 ARTICLE V 

MISCELLANEOUS 
 5.1 Fees
and Expenses. The Company shall pay all fees and expenses incurred by the Purchasers incident to the negotiation, preparation, execution, delivery and performance of this Agreement, as well as Transfer Agent fees, stamp taxes and other taxes and
duties levied in connection with the delivery of the Shares to the Purchasers. 
 5.2 Entire Agreement. The Transaction Documents,
together with the exhibits and schedules thereto, contain the entire understanding of the parties with respect to the subject matter hereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which
the parties acknowledge have been merged into such documents, exhibits and schedules. At or after the Closing, and without further consideration, the Company and the Purchasers will execute and deliver to the other such further documents as may be
reasonably requested in order to give practical effect to the intention of the parties under the Transaction Documents. 
 5.3
Notices. Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice
or communication is delivered via facsimile at the facsimile number set forth on the signature pages attached hereto prior to 5:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such
notice or communication is delivered via facsimile at the facsimile number set forth on the signature pages attached hereto on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (c) the 2nd Trading
Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service, or (d) upon actual receipt by the party to whom such notice is required to be given. The address for such notices and communications shall be as
set forth on the signature pages for the Company and Exhibit A attached hereto for the Purchasers. 
 5.4 Amendments; Waivers. No
provision of this Agreement may be waived or amended except in a written instrument signed, in the case of an amendment, by the Company and each Purchaser. No waiver of any default with respect to any provision, condition or requirement of this
Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right
hereunder in any manner impair the exercise of any such right. No consideration shall be offered or paid to any Purchaser to amend or consent to a waiver or modification of any provision of any Transaction Document unless the same consideration is
also offered to all Purchasers who then hold Securities. 
 5.5 Headings and Construction. The headings herein are for convenience
only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent, and
no rules of strict construction will be applied against any party. This Agreement shall be construed as if drafted jointly by the parties, and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of the
authorship of any provisions of this Agreement or any of the Transaction Documents. 

  
 22 

 5.6 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit
of the parties and their successors and permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of each Purchaser (other than by merger). Any Purchaser may assign any or
all of its rights under this Agreement to any Person to whom such Purchaser assigns or transfers any Shares, provided such transferee agrees in writing to be bound, with respect to the transferred Shares, by the provisions of the Transaction
Documents that apply to the “Purchasers.” 
 5.7 No Third-Party Beneficiaries. This Agreement is intended for the
benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 

5.8 Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be
governed by and construed and enforced in accordance with the internal laws of the State of Florida, without regard to the principles of conflicts of law thereof. Each party agrees that all legal proceedings concerning the interpretations,
enforcement and defense of the transactions contemplated by this Agreement and (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, employees or agents) shall be commenced exclusively in the state
and federal courts sitting in the Hillsborough County, Tampa, Florida. 
 5.9 Survival. The representations and warranties contained
herein shall survive the Closing and the delivery of the Shares for a period of eighteen (18) months. 
 5.10 Execution. This
Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it
being understood that both parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and
binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature page were an original thereof. 

5.11 Severability. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be
invalid, illegal, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall
use their commercially reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be
the intention of the parties that they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable. 

  
 23 

 5.12 Rescission and Withdrawal Right. Notwithstanding anything to the contrary contained
in (and without limiting any similar provisions of) any of the other Transaction Documents, whenever any Purchaser exercises a right, election, demand or option under a Transaction Document and the Company does not timely and materially perform its
related obligations within the periods therein provided, then such Purchaser may rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant notice, demand or election in whole or in part without
prejudice to its future actions and rights. 
 5.13 Replacement of Shares. If any certificate or instrument evidencing any Shares is
mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of
evidence reasonably satisfactory to the Company and the Transfer Agent of such loss, theft or destruction and the execution by the holder thereof of a customary lost certificate affidavit of that fact and an agreement to indemnify and hold harmless
the Company and the Transfer Agent for any losses in connection therewith or, if required by the Transfer Agent, a bond in such form and amount as is required by the Transfer Agent. The applicants for a new certificate or instrument under such
circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Shares. If a replacement certificate or instrument evidencing any Shares is requested due to a mutilation thereof, the Company may require
delivery of such mutilated certificate or instrument as a condition precedent to any issuance of a replacement. 
 5.14 Remedies. In
addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of the Purchasers and the Company will be entitled to specific performance under the Transaction Documents. The parties agree
that monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents and hereby agrees to waive and not to assert in any action for specific performance of any
such obligation the defense that a remedy at law would be adequate. 
 5.15 Independent Nature of Purchasers’ Obligations and
Rights. The obligations of each Purchaser under any Transaction Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance or non-performance of the
obligations of any other Purchaser under any Transaction Document. Nothing contained herein or in any other Transaction Document, and no action taken by any Purchaser pursuant thereto, shall be deemed to constitute the Purchasers as a partnership,
an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by the Transaction Documents.
Each Purchaser shall be entitled to independently protect and enforce its rights, including without limitation, the rights arising out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser
to be joined as an additional party in any proceeding for such purpose. Each Purchaser has been represented by its own separate legal counsel in their review and negotiation of the Transaction Documents. The Company has elected to provide all
Purchasers with the same terms and Transaction Documents for the convenience of the Company and not because it was required or requested to do so by the Purchasers. 

  
 24 

 5.16 No Promotion. The Company agrees that it will not, and shall cause each of its
Subsidiaries to not, without the prior written consent of a Purchaser, use in advertising, publicity, or otherwise the name of such Purchaser, or any partner or employee of such Purchaser, nor any trade name, trademark, trade device, service mark,
symbol or any abbreviation, contraction or simulation thereof owned by such Purchaser or any of their respective affiliates. The Company further agrees that it shall obtain the written consent of such Purchaser prior to the Company’s or
any of its Subsidiaries’ issuance of any public statement detailing the purchase of Shares by Purchasers pursuant to this Agreement. 

5.17 Exculpation Among Purchasers. Each Purchaser acknowledges that it is not relying upon any person, firm or corporation (including
without limitation any other Purchaser), other than the Company and its officers and directors (acting in their capacity as representatives of the Company), in deciding to invest and in making its investment in the Company. Each Purchaser agrees
that neither other Purchaser nor the respective controlling persons, officers, directors, partners, agents or employees of any other Purchaser shall be liable to such Purchaser for any losses incurred by such Purchaser in connection with its
investment in the Company. 
 5.18 Company Acknowledgement. The Company acknowledges and agrees that (i) each of the Purchasers
is participating in the transactions contemplated by this Agreement and the other Transaction Documents at the Company’s request and the Company has concluded that such participation is in the Company’s best interest and is consistent with
the Company’s objectives and (ii) each of the Purchasers is acting solely in the capacity of an arm’s length purchaser. The Company further acknowledges that no Purchaser is acting or has acted as an advisor, agent or fiduciary of the
Company (or in any similar capacity) with respect to this Agreement or the other Transaction Documents and any advice given by any Purchaser or any of its respective representatives in connection with this Agreement or the other Transaction
Documents is merely incidental to the Purchasers’ purchase of Shares. The Company further represents to each Purchaser that the Company’s decision to enter into this Agreement has been based solely on the independent evaluation of the
transactions contemplated hereby by the Company and its representatives. 
 5.20 Legal Counsel. Each party hereby acknowledges that
Shumaker, Loop & Kendrick, LLP, prepared the Purchase Agreement on behalf of and in the course of its representation of the Company and that each party (i) has been advised that a conflict may exist between its interests and those of
each other party, (ii) has been advised by Shumaker, Loop & Kendrick, LLP, to seek the advice of independent counsel, and (iii) has had the opportunity to seek the advice of independent counsel. 

(Signature Pages Follow) 

  
 25 

 IN WITNESS WHEREOF, the parties hereto have caused this Stock Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above. 
  

			
	ORAGENICS, INC.
		
	By:	 	 /s/ Michael O. Sullivan

	Name:	 	Michael O. Sullivan
	Title:	 	Chief Financial Officer
	
	KOSKI FAMILY LIMITED PARTNERSHIP
		
	By:	 	 /s/ Christine Koski

	Name:	 	Christine Koski
	Title:	 	Managing General Partner
	
	INTREXON CORPORATION
		
	By:	 	 /s/ Donald P. Lehr

		 	Name: Donald :Lehr
		 	Title: Chief Legal Officer
	
	 /s/ Frederick W. Telling

	Dr. Frederick W. Telling, Individually

 [Signature Page to Stock Purchase Agreement] 

 EXHIBIT A 
  

																	
	 Purchaser and address for notice
	  	Subscription
Amount	 	  	Shares	 	  	Cash	 	  	Promissory Note	 
	 Koski Family Limited Partnership

 
 3525 Turtle Creek Blvd, 19B

Dallas, TX 75219
  

Attention: Christine Koski
	  	$	3,000,000	  	  	 	5,815,080	  	  	$	1,000,000	  	  	$	2,000,000	  
	 Intrexon Corporation
  

20374 Seneca Meadows

Parkway Germantown,

MD 20876
  

Attention: Legal Department
	  	$	1,166,666.06	  	  	 	2,261,419	  	  	$	1,166,666.06	  	  	 	N/A	  
	 Dr. Frederick W. Telling

 
 2068 Country Club Drive

Port Orange FL 32128
	  	$	500,000	  	  	 	969,180	  	  	$	500,000	  	  	 	N/A	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Total
	  	$	4,666,666.06	  	  	 	9,045,679	  	  	$	2,666,666.06	  	  	$	2,000,000.00

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