Document:

THE
SHARES OF COMMON STOCK ACQUIRED HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, STATE SECURITIES LAWS OR
THE LAWS OF ANY COUNTRY OUTSIDE THE UNITED STATES. ISSUANCE OF THE SHARES OF COMMON STOCK IS MADE IN RELIANCE UPON AN EXEMPTION
FROM REGISTRATION UNDER SUCH LAWS. THE SHARES OF COMMON STOCK CANNOT BE SOLD, ASSIGNED OR OTHERWISE TRANSFERRED UNLESS THEY ARE
REGISTERED IN COMPLIANCE WITH FEDERAL AND STATE SECURITIES LAWS OR PURSUANT TO AN EXEMPTION THEREFROM. IN ADDITION, TRANSFER OF
THE SHARES OF COMMON STOCK WILL BE RESTRICTED UNDER PROVENTION BIO, INC.’S BYLAWS.

 

PROVENTION
BIO, INC.

 

Common
Stock Subscription Agreement

 

This
Subscription Agreement (the “Agreement”) is made and entered into as of the date indicated on the signature
page hereto, by and between Provention Bio, Inc., a Delaware corporation (the “Company”), and Amgen Inc., a
Delaware corporation (“Purchaser”);

 

Whereas,
the Company and Purchaser have entered into that certain License and Collaboration Agreement dated as of November 5, 2018 (the
“License Agreement”) and other ancillary agreements (collectively, with the License Agreement, the “Transaction
Documents”) related to the development by Company of the Product(s) (as defined in the License Agreement);

 

Whereas,
the Company intends to complete an offering of its shares of common stock, par value $0.0001 per share (“Common Stock”)
registered with the Securities and Exchange Commission (the “Registered Offering”);

 

Whereas,
Purchaser desires to purchase, and the Company desires to issue and sell, shares of Common Stock in a private placement on the
terms and conditions set forth herein contemporaneously with the closing of the Registered Offering.

 

Agreement

 

Now,
Therefore, in consideration of the foregoing recitals and the mutual promises, representations, warranties, and covenants
hereinafter set forth and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
the parties hereto agree as follows:

 

		I.	Agreement
                                         to Sell and Purchase.

 

		A.	Subscription
                                         and Purchase. Subject to the terms and conditions hereof, at the Closing (as defined
                                         below), Purchaser hereby subscribes for and agrees to purchase from the Company 2,500,000
                                         shares of Common Stock (such purchased shares of Common Stock, the “Purchased
                                         Common Stock”) at a purchase price of $8.00 per share of Common Stock (the
                                         “Per Share Price” and the Purchased Common Stock multiplied by the
                                         Per Share Price, the “Subscription Amount”).

 

		B.	“Limitations.
                                         Notwithstanding anything herein to the contrary, the Purchaser shall have no obligation
                                         under this Agreement to subscribe for or purchase a number of shares of Common Stock
                                         that, after giving effect to such purchase, would cause Purchaser to own more than 19.5%
                                         of the Company’s outstanding shares of Common Stock as of the date of such issuance,
                                         provided the foregoing shall not relieve Amgen of its obligation to purchase equity securities
                                         of the Company up to and including the Purchase Cap subject to the terms and conditions
                                         set forth herein and in the Transaction Documents.

 

    	 	 	 

    	 

    

 

		II.	Closing,
                                         Delivery and Payment, Termination.

 

		A.	Closing.
                                         The closing of the sale and purchase of the Purchased Common Stock under this Agreement
                                         shall take place contemporaneously with the closing of the Registered Offering (the “Closing”)
                                         at the offices of Lowenstein Sandler LLP, One Lowenstein Drive, Roseland New Jersey 07068
                                         or at such time and place as the Company and Purchaser may mutually agree (such date
                                         on which the Closing occurs is hereafter referred to as the “Closing Date”).

 

		B.	Purchaser
                                         Deliveries. At the Closing, subject to the terms and conditions hereof, the Purchaser
                                         will deliver to the Company:

 

		1.	this
                                         Agreement duly executed by the Purchaser; and

 

		2.	the
                                         Subscription Amount by wire transfer of immediately available funds made payable to the
                                         Company.

 

		C.	Company
                                         Deliveries. At the Closing, subject to the terms and conditions hereof, the Company
                                         will deliver to the Purchaser:

 

		1.	this
                                         Agreement duly executed by the Company; and

 

		2.	a
                                         copy of the irrevocable instructions to the Company’s transfer agent instructing
                                         such transfer agent to deliver, on an expedited basis, a certificate evidencing the number
                                         of Purchased Common Stock, registered in the name of the Purchaser, which shall include
                                         the Securities Act Legend and Lockup Legend (each defined below).

 

		D.	Closing
                                         Condition. The obligations of the Purchaser and the Company to consummate the transactions
                                         contemplated by this Agreement are conditioned on the Company’s completion of the
                                         Registered Offering with cumulative net proceeds to the Company (excluding the amount
                                         invested by Purchaser hereunder) of at least $25,000,000.

 

		E.	Termination.
                                         In the event the closing of the Registered Offering has not occurred on or prior to September
                                         30, 2019, this Agreement shall automatically terminate unless extended by the Company
                                         and Purchaser and upon termination neither the Company nor Purchaser shall have any obligations
                                         under this Agreement; provided, that such termination shall have no effect on the Company’s
                                         or Purchaser’s continuing obligation under the License Agreement.

 

		III.	Representations
                                         and Warranties of the Company.

 

The
Company hereby represents and warrants to Purchaser as of the date of this Agreement as set forth below.

 

		A.	Organization,
                                         Good Standing and Qualification. The Company and each of the Company’s subsidiaries
                                         (each a “Subsidiary”), if any, is a corporation duly organized, validly
                                         existing and in good standing under the laws of the state of its incorporation or organization.
                                         The Company has all requisite corporate power and authority to (1) own and operate its
                                         properties and assets, (2) execute and deliver this Agreement, (3) issue and sell the
                                         Purchased Common Stock, (4) carry out the provisions of this Agreement, and (5) carry
                                         on its business as presently conducted and as presently proposed to be conducted. The
                                         Company and each Subsidiary is duly authorized to do business and is in good standing
                                         in all jurisdictions in which the nature of its activities and of its properties makes
                                         such qualification necessary, except for those jurisdictions in which failure to do so
                                         would not, individually or in the aggregate, reasonably be expected to have a material
                                         adverse effect on the Company or its business or its ability to perform its obligations
                                         under the Transaction Documents.

 

		B.	Authorization;
                                         Binding Obligations. All corporate action on the part of the Company, its officers,
                                         Board of Directors and shareholders necessary for the authorization of this Agreement,
                                         the performance of all obligations of the Company hereunder at the Closing and the authorization,
                                         sale, issuance and delivery of the Purchased Common Stock pursuant hereto has been taken
                                         or will be taken prior to the Closing. This Agreement, when executed and delivered, will
                                         be a valid and binding obligation of the Company enforceable in accordance with its terms
                                         except (1) as limited by the applicable bankruptcy, insolvency, reorganization, moratorium
                                         or other laws of general application affecting enforcement of creditors’ rights,
                                         and (2) general principles of equity that restrict the availability of equitable remedies.

 

    	 	 	 

    	 

    

 

		C.	No
                                         Conflicts. The execution, delivery and performance by the Company of this Agreement
                                         and the other Transaction Documents it is party to and the consummation by the Company
                                         of the transactions contemplated hereby and thereby do not, and will not, (i) conflict
                                         with or violate any provision of the Company’s or any Subsidiary’s certificate
                                         or articles of incorporation, bylaws or other organizational or charter documents, (ii)
                                         in any material respect, conflict with, or constitute a default (or an event that with
                                         notice or lapse of time or both would become a default) under, or give to others any
                                         rights of termination, amendment, acceleration or cancellation (with or without notice,
                                         lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing
                                         a Company or Subsidiary debt or otherwise) or other understanding to which the Company
                                         or Subsidiary is a party or by which any property or asset of the Company or Subsidiary
                                         is bound, or affected, or (iii) in any material respect, result in a violation of any
                                         law, rule, regulation, order, judgment, injunction, decree or other restriction of any
                                         court or governmental authority to which the Company or any Subsidiary is subject (including,
                                         assuming the accuracy of the representations and warranties of the Purchaser set forth
                                         in Section IV hereof, federal and state securities laws and regulations and the rules
                                         and regulations of any self-regulatory organization to which the Company any Subsidiary
                                         or their respective securities are subject, including all applicable trading markets),
                                         or by which any property or asset of the Company is bound or affected, except in the
                                         case of clauses (ii) and (iii) such as would not, individually or in the aggregate, reasonably
                                         be expected to have a material adverse effect on the Company or its business or its ability
                                         to perform its obligations under the Transaction Documents.

 

		D.	The
                                         Purchased Common Stock. The Purchased Common Stock is duly authorized and, when issued
                                         and paid for in accordance with this Agreement, will be duly and validly issued, fully
                                         paid and nonassessable, free and clear of all Liens (other than restrictions on transfer
                                         set forth in this Agreement or imposed by applicable securities laws) and will not be
                                         subject to preemptive or similar rights of stockholders.

 

		E.	SEC
                                         Reports; Financial Statements. The Company has filed all reports, schedules, forms,
                                         statements and other documents required to be filed by the Company under the Securities
                                         Act of 1933, as amended (the “Securities Act”) and the Exchange Act,
                                         including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the
                                         date hereof (or such shorter period as the Company was required by law or regulation
                                         to file such material) (the foregoing materials, including the exhibits thereto and documents
                                         incorporated by reference therein, being collectively referred to herein as the “SEC
                                         Reports”) on a timely basis or has received a valid extension of such time
                                         of filing and has filed any such SEC Reports prior to the expiration of any such extension.
                                         As of their respective dates, the SEC Reports complied in all material respects with
                                         the requirements of the Securities Act and the Exchange Act, as applicable, and none
                                         of the SEC Reports, when filed, contained any untrue statement of a material fact or
                                         omitted to state a material fact required to be stated therein or necessary in order
                                         to make the statements therein, in the light of the circumstances under which they were
                                         made, not misleading. The Company has never been an issuer subject to Rule 144(i) under
                                         the Securities Act. The financial statements of the Company included in the SEC Reports
                                         comply in all material respects with applicable accounting requirements and the rules
                                         and regulations of the Securities and Exchange Commission (the “Commission”)
                                         with respect thereto as in effect at the time of filing. Such financial statements have
                                         been prepared in accordance with United States generally accepted accounting principles
                                         applied on a consistent basis during the periods involved (“GAAP”),
                                         except as may be otherwise specified in such financial statements or the notes thereto
                                         and except that unaudited financial statements may not contain all footnotes required
                                         by GAAP, and fairly present in all material respects the financial position of the Company
                                         and its consolidated Subsidiaries as of and for the dates thereof and the results of
                                         operations and cash flows for the periods then ended, subject, in the case of unaudited
                                         statements, to normal, immaterial, year-end audit adjustments.

 

    	 	 	 

    	 

    

 

		F.	Material
                                         Changes; Undisclosed Events, Liabilities or Developments. Since the date of the latest
                                         audited financial statements included within the SEC Reports, except as specifically
                                         disclosed in a subsequent SEC Report filed prior to the date hereof: (i) there has been
                                         no event, occurrence or development that has had or that would reasonably be expected
                                         to result in a material adverse effect on the Company or its business or its ability
                                         to perform its obligations under the Transaction Documents, (ii) the Company has not
                                         incurred any liabilities (contingent or otherwise) other than (A) trade payables and
                                         accrued expenses incurred in the ordinary course of business consistent with past practice
                                         and (B) liabilities not required to be reflected in the Company’s financial statements
                                         pursuant to GAAP or disclosed in filings made with the Commission, (iii) the Company
                                         has not altered its method of accounting, (iv) the Company has not declared or made any
                                         dividend or distribution of cash or other property to its stockholders or purchased,
                                         redeemed or made any agreements to purchase or redeem any shares of its capital stock
                                         and (v) the Company has not issued any equity securities to any officer, director or
                                         affiliate, except pursuant to existing Company stock option plans. The Company does not
                                         have pending before the Commission any request for confidential treatment of information.
                                         Except for the issuance of the Purchased Common Stock contemplated by this Agreement,
                                         no event, liability, fact, circumstance, occurrence or development has occurred or exists,
                                         or is reasonably expected to occur or exist, with respect to the Company or its Subsidiaries
                                         or their respective businesses, properties, operations, assets or financial condition,
                                         that would be required to be disclosed by the Company under applicable securities laws
                                         at the time this representation is made or deemed made that has not been publicly disclosed
                                         at least 1 trading day prior to the date that this representation is made.

 

		G.	Compliance
                                         with Laws. Except as described in the SEC Reports, the Company and the Subsidiaries
                                         are and at all times have been in full compliance with all statutes, rules, regulations,
                                         or guidance that are necessary for the ownership of their respective properties and the
                                         conduct of their respective businesses (including, without limitation, those administered
                                         by the Food & Drug Administration of the U.S. Department of Health and Human Services
                                         (the “FDA”) or by any foreign, federal, state or local governmental
                                         or regulatory authority performing functions similar to those performed by the FDA),
                                         except as would not, individually or in the aggregate, reasonably be expected to have
                                         a material adverse effect on the Company or its business or its ability to perform its
                                         obligations under the Transaction Documents.

 

		H.	Brokers.
                                         The Company has not retained any investment banker or broker in connection with the
                                         transactions contemplated by this Agreement.

 

		IV.	Representations
                                         and Warranties of the Purchaser.

 

Purchaser
hereby represents and warrants to the Company as follows:

 

		A.	Organization;
                                         Authority. The Purchaser is a corporation duly organized, validly existing and in
                                         good standing under the laws of the State of Delaware with the requisite corporate power
                                         and authority to enter into and to consummate the transactions contemplated by this Agreement
                                         and otherwise to carry out its obligations hereunder. The purchase by the Purchaser of
                                         the Purchased Common Stock hereunder has been duly authorized by all necessary corporate
                                         action on the part of the Purchaser. This Agreement has been duly executed and delivered
                                         by the Purchaser and constitutes the valid and binding obligation of the Purchaser, enforceable
                                         against it in accordance with its terms, except (i) as limited by general equitable principles
                                         and applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general
                                         application affecting enforcement of creditors’ rights generally, and (ii) as limited
                                         by laws relating to the availability of specific performance, injunctive relief or other
                                         equitable remedies.

 

    	 	 	 

    	 

    

 

		B.	No
                                         Public Sale or Distribution. The Purchaser is acquiring the Purchased Common Stock
                                         for its own account and not with a view towards, or for resale in connection with, the
                                         public sale or distribution thereof, except pursuant to sales registered under the Securities
                                         Act or under an exemption from such registration and in compliance with applicable federal
                                         and state securities laws, and the Purchaser does not have a present arrangement to effect
                                         any distribution of the Purchased Common Stock to or through any person or entity; provided,
                                         however, that by making the representations herein and except as expressly set
                                         forth herein, such Purchaser does not agree to hold any of the Purchased Common Stock
                                         for any minimum or other specific term and reserves the right to dispose of the Purchased
                                         Common Stock at any time in accordance with or pursuant to a registration statement or
                                         an exemption under the Securities Act.

 

		C.	Purchaser
                                         Status. At the time the Purchaser was offered the Purchased Common Stock, it was,
                                         and at the date hereof it is an “accredited investor” as defined in Rule
                                         501(a) under the Securities Act or a “qualified institutional buyer” as defined
                                         in Rule 144A(a) under the Securities Act. Such Purchaser is not a registered broker dealer
                                         registered under Section 15(a) of the Exchange Act, or a member of the Financial Industry
                                         Regulatory Authority, Inc. or an entity engaged in the business of being a broker dealer.

 

		D.	Experience
                                         of Such Purchaser. The Purchaser, either alone or together with its representatives,
                                         has such knowledge, sophistication and experience in business and financial matters so
                                         as to be capable of evaluating the merits and risks of the prospective investment in
                                         the Purchased Common Stock, and has so evaluated the merits and risks of such investment.
                                         The Purchaser understands that it must bear the economic risk of this investment in the
                                         Purchased Common Stock indefinitely, and is able to bear such risk and is able to afford
                                         a complete loss of such investment.

 

		E.	No
                                         Conflicts. The execution, delivery and performance by the Purchaser of this Agreement
                                         and the other Transaction Documents it is a party to and the consummation by the Purchaser
                                         of the transactions contemplated hereby and thereby do not and will not (i) result in
                                         a violation of the organizational documents of the Purchaser or (ii) conflict with, or
                                         constitute a default (or an event which with notice or lapse of time or both would become
                                         a default) under, or give to others any rights of termination, amendment, acceleration
                                         or cancellation of, any agreement, indenture or instrument to which the Purchaser is
                                         a party, or (iii) result in a violation of any law, rule, regulation, order, judgment
                                         or decree (including federal and state securities laws) applicable to the Purchaser,
                                         except in the case of clauses (ii) and (iii) above, for such that are not material and
                                         do not otherwise affect the ability of the Purchaser to consummate the transactions contemplated
                                         hereby

 

		F.	Restricted
                                         Securities. The Purchaser understands that the Purchased Common Stock are characterized
                                         as “restricted securities” under the U.S. federal securities laws inasmuch
                                         as they are being acquired from the Company in a transaction not involving a public offering
                                         and that under such laws and applicable regulations such securities may be resold without
                                         registration under the Securities Act only in certain limited circumstances. The Purchaser
                                         further understands that the certificates evidencing the Purchased Common Stock, purchased
                                         by it will contain the following legend (the “Securities Act Legend”):

 

THESE
SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE
UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR
ANY APPLICABLE STATE SECURITIES LAWS AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT AND IN COMPLIANCE WITH APPLICABLE STATE SECURITIES LAWS OR BLUE SKY LAWS

 

    	 	 	 

    	 

    

 

		G.	Prohibited
                                         Transactions. The Purchaser has not, directly or indirectly, and no Person acting
                                         on behalf of or pursuant to any understanding with the Purchaser has, engaged in any
                                         purchases or sales in the securities, including derivatives, of the Company (including,
                                         without limitation, any Short Sales (a “Transaction”) involving any
                                         of the Company’s securities) since the time that the Purchaser was first contacted
                                         by the Company or any other Person regarding an investment in the Company. The Purchaser
                                         covenants that neither it nor any Person acting on its behalf or pursuant to any understanding
                                         with the Purchaser will engage, directly or indirectly, in any Transactions in the securities
                                         of the Company (including Short Sales) prior to the time the transactions contemplated
                                         by this Agreement are publicly disclosed.

 

		H.	Brokers.
                                         Purchaser has not retained any investment banker or broker in connection with the
                                         transactions contemplated by this Agreement.

 

		V.	Lock-Up.

 

		A.	Lock-Up.
                                         During the six (6) month period following the Closing, the Purchaser shall not, without
                                         the consent of the Company, issue, sell, offer or agree to sell, grant any option for
                                         the sale of, pledge, enter into any swap, derivative transaction or other arrangement
                                         that transfers to another, in whole or in part, any of the economic consequences of ownership
                                         of any of the Purchased Common Stock (whether any such transaction is to be settled by
                                         delivery of Purchased Common Stock, other securities, cash or other consideration) or
                                         otherwise dispose (or publicly announce the undersigned’s intention to do any of
                                         the foregoing) of, directly or indirectly, any Purchased Common Stock. The Purchaser
                                         understands that the certificates evidencing the Purchased Common Stock, purchased by
                                         it will include a legend evidencing the lock-up contemplated herein (the “Lock-Up
                                         Legend”).

 

		VI.	Miscellaneous.

 

		A.	Governing
                                         Law; Venue. ALL QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY, ENFORCEMENT AND
                                         INTERPRETATION OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH
                                         THE LAWS OF THE STATE OF NEW YORK. THE COMPANY AND THE PURCHASER HEREBY IRREVOCABLY SUBMIT
                                         TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS SITTING IN THE CITY OF
                                         NEW YORK, BOROUGH OF MANHATTAN FOR THE ADJUDICATION OF ANY DISPUTE BROUGHT BY THE COMPANY
                                         OR THE INVESTOR HEREUNDER, IN CONNECTION HEREWITH OR WITH ANY TRANSACTION CONTEMPLATED
                                         HEREBY OR DISCUSSED HEREIN, AND HEREBY IRREVOCABLY WAIVE, AND AGREE NOT TO ASSERT IN
                                         ANY SUIT, ACTION OR PROCEEDING BROUGHT BY THE COMPANY OR THE INVESTOR, ANY CLAIM THAT
                                         IT IS NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, OR THAT SUCH SUIT,
                                         ACTION OR PROCEEDING IS IMPROPER. EACH PARTY HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE
                                         OF PROCESS AND CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING
                                         BY MAILING A COPY THEREOF VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH
                                         EVIDENCE OF DELIVERY) TO SUCH PARTY AT THE ADDRESS IN EFFECT FOR NOTICES TO IT UNDER
                                         THIS AGREEMENT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE
                                         OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY
                                         WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW.

 

    	 	 	 

    	 

    

 

		B.	Fees
                                         and Expenses. Except as expressly set forth in the Transaction Documents to the contrary,
                                         each party shall pay the fees and expenses of its advisers, counsel, accountants and
                                         other experts, if any, and all other expenses incurred by such party incident to the
                                         negotiation, preparation, execution, delivery and performance of this Agreement. The
                                         Company shall pay all Transfer Agent fees, stamp taxes and other taxes and duties levied
                                         in connection with the sale and issuance of the Purchased Common Shares.

 

		C.	Successors
                                         and Assigns. Neither this Agreement nor any rights or obligations hereunder may be
                                         assigned or otherwise transferred by either party without the prior written consent of
                                         the other party; provided, however, that either party may assign or otherwise transfer
                                         this Agreement and its rights and obligations hereunder without the other party’s
                                         consent in connection with the transfer or sale of all or substantially all of the business
                                         or assets of such party relating to the subject matter of this Agreement to a Third Party,
                                         whether by merger, consolidation, divesture, restructure, sale of stock, sale of assets
                                         or otherwise. This Agreement shall inure to the benefit of successors and assigns of
                                         the Company and, subject to the restrictions on transfer described herein, be binding
                                         upon Purchaser, Purchaser’s successors and permitted assigns.

 

		D.	Entire
                                         Agreement; Amendment; Waiver. This Agreement contains the entire understanding of
                                         the parties with respect to the subject matter hereof and supersedes all prior agreements
                                         and understandings, oral or written, with respect to such matters, which the parties
                                         acknowledge have been merged into such documents. At or after the Closing, and without
                                         further consideration, the Company will execute and deliver to the Purchaser such further
                                         documents as may be reasonably requested in order to give practical effect to the intention
                                         of the parties under this Agreement. This Agreement may not be amended, modified or revoked,
                                         in whole or in part, or any provisions hereof waived, except by an agreement in writing
                                         signed by each of the parties hereto.

 

		E.	Severability.
                                         If one or more of the provisions of this Agreement are held to be unenforceable under
                                         applicable law, the parties agree to renegotiate such provision in good faith. In the
                                         event that the parties can reach a mutually agreeable and enforceable replacement for
                                         such provision, then (1) such provision shall be excluded from this Agreement, (2) the
                                         balance of the Agreement shall be interpreted as if such provision were so excluded and
                                         (3) the balance of the Agreement shall be enforceable in accordance with its terms.

 

		F.	Notices.
                                         All notices required or permitted hereunder shall be in writing and shall be deemed
                                         effectively given: (1) upon personal delivery to the party to be notified, (2) five (5)
                                         calendar days after having been sent by registered or certified mail, return receipt
                                         requested, postage prepaid, or (3) one (1) business day after deposit with a nationally
                                         recognized overnight courier, specifying next day delivery, with written verification
                                         of receipt. All communications shall be sent to the other party hereto at such party’s
                                         address hereinafter set forth on the signature page hereof, or at such other address
                                         as such party may designate by ten (10) days advance written notice to the other party
                                         hereto.

 

		G.	Further
                                         Assurances. The parties agree to take all such further action(s) as may reasonably
                                         be necessary to carry out and consummate this Agreement as soon as practicable, and to
                                         take whatever steps may be necessary to obtain any governmental approval in connection
                                         with or otherwise qualify the issuance of the securities that are the subject of this
                                         Agreement.

 

		H.	Titles
                                         and Subtitles. The titles of the sections and subsections of the Agreement are for
                                         convenience of reference only and are not to be considered in construing this Agreement.

 

    	 	 	 

    	 

    

 

		I.	Counterparts.
                                         This Agreement may be manually or electronically executed in one or more counterparts
                                         (delivery of which may occur via facsimile or electronic transmission, including as an
                                         attachment to an electronic mail message in “pdf” or similar format), each
                                         of which shall constitute an original, but all of which taken together shall constitute
                                         one and the same instrument. A signed copy of this Agreement delivered by facsimile,
                                         e-mail or other means of electronic transmission shall be deemed to have the same legal
                                         effect as delivery of an original signed copy of this Agreement.

 

		J.	Replacement
                                         of Certificates. If any certificate or instrument evidencing any Purchased Common
                                         Stock is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be
                                         issued in exchange and substitution for and upon cancellation thereof, or in lieu of
                                         and substitution therefor, a new certificate or instrument, but only upon receipt of
                                         evidence reasonably satisfactory to the Company of such loss, theft or destruction and
                                         the execution by the holder thereof of a customary lost certificate affidavit of that
                                         fact and an agreement to indemnify and hold harmless the Company for any losses in connection
                                         therewith.

 

		K.	Remedies.
                                         In addition to being entitled to exercise all rights provided herein or granted by
                                         law, including recovery of damages, each of the Purchaser and the Company will be entitled
                                         to seek specific performance under this Agreement. The parties agree that monetary damages
                                         may not be adequate compensation for any loss incurred by reason of any breach of obligations
                                         described in the foregoing sentence and hereby agree to waive in any action for specific
                                         performance of any such obligation (other than in connection with any action for a temporary
                                         restraining order) the defense that a remedy at law would be adequate.

 

		L.	Rules
                                         of Construction. The parties hereto agree that they have been represented by counsel
                                         of their own choosing during the negotiation and execution of this Agreement and, therefore,
                                         waive the application of any law, regulation, holding or rule of construction providing
                                         that ambiguities in an agreement or any other document will be construed against the
                                         party drafting such agreement or document.

 

[SIGNATURE
PAGE FOLLOWS]

 

    	 	 	 

    	 

    

 

In
Witness Whereof, the parties hereto have executed this Subscription Agreement as of the last date set forth in the spaces
provided below on which a party executed this Agreement.

 

PURCHASER:

 

I
have read and understand the Subscription Agreement contained herein.

 

Entity:

Amgen
Inc.

 

	By:	/s/
    David W. Meline	 
	Name: 	David
    W. Meline	 
	Title:	EVP
    & Chief Financial Officer	 

 

Subscription
Amount ($)

$20,000,000

 

Number
of Shares of Common Stock

2,500,000

 

Tax
ID or SS#: [****]

 

Address
of Stockholder:

[****]

Telephone
Number: [****]

 

September
18, 2019

Date

 

    	 	 	 

    	 

    

 

In
Witness Whereof, the parties hereto have executed this Subscription Agreement as of the last date set forth in the spaces
provided below on which a party executed this Agreement.

 

COMPANY:

 

PROVENTION
BIO, INC.

 

	By:	/s/
    Ashleigh Palmer	 
	Name: 
    	Ashleigh
    Palmer	 
	Title:	Chief
    Executive Officer	 
	Date:
    	September
    18, 2019	 

 

Address:

Provention
Bio Inc

PO
Box 666

Oldwick,
NJ 08858

 

Email: [****]Exhibit 10.1

    

     

    

    
      THIRD AMENDMENT TO COMMERCIAL

      BUSINESS LOAN AGREEMENT FOR TERM LOANS AND LINES OF CREDIT

      

      

      THIS THIRD AMENDMENT TO COMMERICAL BUSINESS LOAN AGREEMENT FOR TERM LOANS AND LINES OF CREDIT (this “Third Amendment”) is dated September 19, 2019, by and among VIEMED, INC., a Delaware corporation (“Viemed”), SLEEP MANAGEMENT, L.L.C. (“Sleep

            Management”), a Louisiana limited liability company, and HOME SLEEP DELIVERED, L.L.C. (“Home Sleep”), a Louisiana limited liability company (collectively, the “Borrower”), and HANCOCK WHITNEY BANK, a Mississippi state chartered bank, formally known as Whitney Bank (the “Lender”).  The Borrower, Guarantor, if any, and any other person who
          may be liable now or in the future for any portion of any Loans are referred to as “Obligor”, which term means individually, collectively, and interchangeably any, each and/or all of them.

       

      R E C I T A L S:

       

      A.         Borrower and Lender are parties to that certain Commercial Business Loan Agreement for Term Loans and Lines of Credit dated February 21, 2018, pursuant to which the Lender established in
        favor of Borrower, among other things, a revolving line of credit in the maximum aggregate principal amount of $5,000,000.00 (collectively, with all past, present and future amendments and/or restatements, the “Agreement”).

       

      B.          Borrower has now applied to Lender to have the working capital requirement removed.

       

      C.          Lender, subject to the terms and conditions of this Third Amendment, has agreed to Borrower’s requests.          

       

      NOW, THEREFORE, in consideration of the mutual covenants hereunder set forth, Borrower and
          Lender do hereby covenant and agree to amend the Agreement as follows:

      

      

      1.           Revisions to Article A – The Loan or Loans.

      

      

      A.          A new subsection, entitled “TERM LOAN #2,” is hereby added to Section A of the Agreement, immediately below the existing subsection entitled
        “TERM LOAN,” as follows:

      

      

      TERM LOAN #2 to Borrower in the principal amount of
          Five Million and no/100 ($5,000,000.00) Dollars (the “Term Loan #2” which term shall include all renewals, extensions or modifications thereof) bearing interest at the rate of 4.60% per annum from date
          until paid, payable in 36 monthly installments of $148,958.18 commencing on October 19, 2019, and continuing on the same day
          of each month thereafter with a final installment of all outstanding principal and accrued interest due and payable on September 19, 2022, which Term Loan shall be represented by Bank’s standard form of installment note executed on September 19,
          2019 (the “Term Note #2,” which term shall include all renewals, extensions or modifications thereof).

    

     

    

    
      	
              3rd Amendment

            	
              Hancock Whitney Bank

            

    

     

    
      1

      
        

      

    

    2.           Revisions to Article C – Use of Proceeds.  Section C of the Agreement, entitled “USE OF PROCEEDS,” is hereby deleted
      in its entirety and restated as follows:

    

    

    
      
        	

              	C.	
                USE OF PROCEEDS.

              

      

    

    

    

    
      
        
          (1)         Line of Credit.  The proceeds from the Line of
              Credit will be used for the following purpose(s):  (a) working capital and general corporate purposes with a letter of credit sublimit of $2,000,000.00; and (b) Permitted Acquisitions pursuant to Subsection D(15) of this Agreement.

        

      

    

    

    

    
      
        
          (2)         Term Loan.  The proceeds from the Term Loan will be
              used to purchase the commercial office building located at 625 Kaliste Saloom Road, Lafayette, LA 70508.

        

      

    

    

    

    
      
        
          (3)         Term Loan #2.  The proceeds from the Term Loan #2
              will be used for general corporate purposes.     

        

      

    

    

    

    3.          Revisions to Article D – Representations, Warranties and Covenants.  Subsection D(8) of the Agreement, entitled
      “Financial Covenants and Ratios,” is hereby deleted in its entirety and replaced as follows:

    

    

    
      
        	

              	(8)	
                Financial Covenants and Ratios.  Borrower shall comply with the following covenants and ratios:

              

      

    

    

    

    (a)          Total Debt to Adjusted EBITDA Ratio.  Borrower, on a consolidated basis, shall maintain a maximum “Total Debt to Adjusted EBITDA Ratio” of not more than 1.50 to 1.00.  Total Debt to Adjusted EBITDA Ratio shall equal Total Debt divided by Adjusted EBITDA.  “Total Debt” is defined as debt for borrowed money plus capitalized leases. “Adjusted EBITDA” is defined as net income before taxation plus depreciation expense plus
      amortization expense plus interest expense plus stock-based compensation plus
      non-cash/non-recurring gain or loss.  Non-cash/non-recurring gains or losses shall not exceed $500,000.00 without Bank’s approval.  This covenant shall be tested quarterly (as of March 31st, June 30th, September 30th, and December 31st) on a rolling four quarters basis.

     

    
      
        	
                3rd Amendment

              	
                Hancock Whitney Bank

              

      

    

    
      2

      
        

      

    

    (b)          Fixed Charge Coverage Ratio.   Borrower,

        on a consolidated basis, shall maintain a minimum “Fixed Charge Coverage Ratio” of not less than 1.35 to 1.00.  “Fixed Charge Coverage Ratio” shall equal (Adjusted EBITDAR less dividends)
        divided by current maturing long-term debt (prior period) plus current maturing capital lease obligations (prior

          period) plus interest expense plus lease expense (COGS & G&A) plus cash taxes.  Current maturing long-term debt (CMLTD) and current maturing capital lease obligations (CMCLO) shall exclude any balloon payments and the maturity of the Revolving Note.  “Adjusted EBITDAR” is defined as net
        income before taxation plus depreciation expense plus amortization expense plus interest expense plus stock-based compensation plus non-cash/non-recurring gain or loss plus lease expense (COGS & G&A).  Non-cash/non-recurring gains or losses shall not exceed $500,000.00 without Bank’s approval.  This covenant shall be tested quarterly (as of March 31st,
        June 30th, September 30th, and December 31st) on a rolling four quarters basis.

     

    (c)           Loan-to-Value Ratio.  Borrower shall maintain a maximum Loan-to-Value Ratio of .85
      (or 85.00%).  For the purposes of this covenant, the term “Loan-to-Value Ratio” shall mean, for any given period, the aggregate outstanding balance of the Term Loan, in principal, accrued interest, and other fees and costs divided by the most recent appraised value of the property located at 625 Kaliste Saloom Road, Lafayette, LA 70508.

     

    4.          Expenses.  Borrower will pay all of the costs, expenses and fees incurred in
      connection with the Agreement, as documented pursuant to the original Agreement, as modified by this Third Amendment and any future amendments, including attorneys’ fees and appraisal fees.

    

    

    5.          Confirmation of Loan Documents and Security.  Each Obligor understands and
      agrees that all other terms, conditions, and provisions of the Agreement and/or the Loan Documents shall remain in full force and effect.  All of the liens, privileges, mortgages, security interests, priorities, and equities existing and to exist
      under and in accordance with the terms of the Agreement, as amended, the Revolving Note, and the Loan Documents are hereby extended and carried forward as security for the Agreement, the Revolving Note, the Loans, and all other indebtedness,
      obligations, and liabilities of the Borrower to Lender.

    

    

    6.          Representations; Resolutions.  As of the date hereof, and after giving effect
      to this Third Amendment, each Obligor confirms, reaffirms, and restates the representations and warranties set forth in the Agreement and the Loan Documents.  Each Obligor further confirms and reaffirms each and every resolution, certificate,
      consent, and/or other authorization provided to Lender, and further represents that each such resolution, certificate, consent, and/or other authorization (i) remains in full force and effect, (ii) stands of record on the books of such Obligor, and
      (iii) may be relied upon by Lender, including without limitation the Authorizations given by Borrower and Guarantor on or about February 21, 2018, as well as any before or after.

    

    

    7.          No Right of Setoff; Release of Claims.  Borrower acknowledges that as of the
      date of this Third Amendment, Borrower has no right to setoff any amount against the amounts owed by Borrower to Lender.  In consideration of this Third Amendment, each Obligor further releases Lender from any and all claims arising on or prior to
      the date of this Third Amendment, known or unknown, in connection with the Agreement, the Loans, the Revolving Note, and/or the Loan Documents.

    

    

    
      
        	
                3rd Amendment

              	
                Hancock Whitney Bank

              

      

    

    
      3

      
        

      

    

    8.          No Course of Dealing.  This Third Amendment shall not establish a course of
      dealing or be construed as evidence of any willingness on Lender’s part to grant other or future amendments, should any be requested, and Lender is under no obligation to grant or approve such other or future amendments.

    

    

    9.          AMENDMENT.  THE AGREEMENT AND THIS THIRD AMENDMENT ARE CREDIT OR LOAN AGREEMENTS AS DESCRIBED IN LOUISIANA REVISED STATUTES
        6:1121, ET SEQ. THERE ARE NO ORAL AGREEMENTS BETWEEN LENDER AND ANY OBLIGOR.  THE AGREEMENT, AS AMENDED BY THIS THIRD AMENDMENT, THE REVOLVING NOTE, AND THE LOAN DOCUMENTS SET FORTH THE ENTIRE AGREEMENT OF
        THE PARTIES WITH RESPECT TO THE SUBJECT MATTER HEREOF AND THEREOF AND SUPERSEDE ALL PRIOR WRITTEN AND ORAL UNDERSTANDINGS BETWEEN THE PARTIES WITH RESPECT TO THE MATTERS HEREIN SET FORTH. THE AGREEMENT, AS AMENDED BY THIS THIRD AMENDMENT, MAY NOT
        BE MODIFIED OR AMENDED EXCEPT BY A WRITING SIGNED AND DELIVERED BY BORROWER AND LENDER.

    

    

    10.          Miscellaneous provisions.

    

    

    a.         This Third Amendment shall be governed by and construed in accordance with the laws of the State of Louisiana.  This Third Amendment may be executed in any number of counterparts, all of
      which counterparts, when taken together, shall constitute one and the same instrument.

    

    

    b.         Except as expressly amended herein, the Agreement and all of the terms, conditions, and provisions set forth therein shall continue in full force and effect. The Agreement, as amended by
      this Third Amendment, is hereby ratified and confirmed by the parties hereto.

    

    

    c.           No novation or satisfaction of any indebtedness, obligations, and/or liabilities owed by any Obligor to Lender is intended by this Third Amendment. 

    

    

    d.           Unless specifically defined in this Third Amendment, capitalized terms used herein shall have the meanings set forth in the Agreement.

    

    

    11.         USA Patriot Act.  Lender is subject to the USA Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Act”) and Lender hereby notifies Borrower that pursuant to the requirements of the Act, Lender is required
      to obtain, verify, and record information that identifies Borrower, which information includes the name and address of Borrower and other information that will allow Lender to identify Borrower in accordance with the Act.  Borrower shall, promptly
      following each request by Lender, provide all documentation and other information requested by Lender in order for Lender to comply with its ongoing obligations under the applicable “know your customer” and anti-money laundering rules and
      regulations, including the Act.

    

    

    
      
        	
                3rd Amendment

              	
                Hancock Whitney Bank

              

      

    

    
      4

      
        

      

    

    
    Executed by the parties as of the date set forth above.

     

    	 	
            Lender:

          
	 	 	 
	 	
            Hancock Whitney Bank,

          
	 	
            a Mississippi state chartered bank

          
	 	 	 
	 	
            By:

          	
            /s/ Grant Guillotte

          
	 	 	
            Grant Guillotte

          
	 	 	
            Senior Vice President

          
	 	 	 
	 	
            Borrower:

          
	 	 	 
	 	
            Viemed, Inc.

          
	 	 	 
	 	
            By:

          	
            /s/ Casey Hoyt

          
	 	 	
            Casey Hoyt

          
	 	 	
            Chief Executive Officer

          
	 	 	 
	 	
            Sleep Management, L.L.C.

          
	 	 	 
	 	
            By:

          	
            /s/ Casey Hoyt

          
	 	 	
            Casey Hoyt

          
	 	 	
            General Manager

          
	 	 	 
	 	
            Home Sleep Delivered, L.L.C.

          
	 	 	 
	 	
            By:

          	
            /s/ Casey Hoyt

          
	 	 	
            Casey Hoyt

          
	 	 	
            General Manager

          

    

    

    

    

    
      
        
          	
                  3rd Amendment

                	
                  Hancock Whitney Bank

                

        

      

    

     

      

    5

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