Document:

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                                                                    Exhibit 10.4

                         QUATRX PHARMACEUTICALS COMPANY
                            STOCK OPTION GRANT NOTICE

     You have been granted the following option to purchase the number of shares
of Common Stock of QUATRX PHARMACEUTICALS COMPANY (the "Company") indicated
below pursuant to the Company's 2000 Equity Incentive Plan:

Name of Optionee: ____________________

Total Number of Shares Granted: __________

Type of Option:    [ ]   Incentive Stock Option

                   [ ]   Nonqualified Stock Option

Exercise Price
per Share:         $__________

Date of Grant:     ______________________

Vesting Schedule:  Subject to the provisions of this Agreement providing for the
                   vesting or termination of the option upon the occurrence of
                   specified events or times, the option will vest and become
                   exercisable in accordance with the following schedule:
                   ____________________________.

Expiration Date:   _________________________

By your signature and the signature of the Company's representative below, you
and the Company agree that this option is granted under and governed by the
terms and conditions of the Stock Option Grant Agreement attached to and made a
part of this document.

OPTIONEE:                               QUATRX PHARMACEUTICALS COMPANY

                                        By:
-------------------------------------       ------------------------------------
PRINT NAME:
DATE:                                   Its:
                                             -----------------------------------

THE OPTION GRANTED PURSUANT TO THIS AGREEMENT AND THE SHARES ISSUABLE UPON
EXERCISE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
OR ANY STATE SECURITIES LAW AND MAY NOT BE SOLD, PLEDGED, OR OTHERWISE
TRANSFERRED UNLESS THEY ARE FIRST REGISTERD UNDER ALL SUCH APPLICABLE ACTS OR
THE COMPANY RECEIVES AN OPINION OF COUNSEL, SATISFACTORY IN FORM AND SUBSTANCE
TO THE COMPANY AND ITS COUNSEL, THAT SUCH TRANSFER MAY BE MADE WITHOUT
REGISTRATION.

<PAGE>

                         QUATRX PHARMACEUTICALS COMPANY
                          STOCK OPTION GRANT AGREEMENT

     This Stock Option Grant Agreement is made by and between Quatrx
Pharmaceuticals Company, a Delaware Corporation, and the Optionee whose name
appears on the Grant Notice to which this Agreement is attached.

     1. DEFINITIONS AND TERMS. Capitalized terms used in this Stock Option Grant
Agreement shall have the meanings set forth in Appendix A. The parties agree and
acknowledge that the Grant Notice is part of and incorporated into this
Agreement.

     2. GRANT OF OPTION AND VESTING. The Company hereby grants to Optionee, as
of the Grant Date shown, an option to purchase up to the number of shares of the
common stock of the Company specified in the Grant Notice. Unless this option is
terminated, or vesting is accelerated, in accordance with the express provisions
of this agreement, the Option Shares will vest in accordance with the Vesting
Schedule. From and after the vesting of the option, Optionee may purchase the
Option Shares at the Exercise Price from time to time prior to the Expiration
Date or earlier termination of this option in accordance with this Agreement.

     3. TERM OF OPTION. Except to the extent otherwise expressly provided in
this Agreement, this option shall expire on the Expiration Date.

     4. EXERCISE OF OPTION.

     (a) Restrictions. This option may not be exercised for fractional shares.
This option may not be exercised for less than 100 shares at any time, provided
that such minimum number will not prevent Optionee from exercising this option
for the full number of Option Shares for which it is then exercisable.

     (b) Manner of Exercise. To exercise this option with respect to all or any
part of the Option Shares for which this option is then exercisable, Optionee
(or any other person or persons exercising the option) must take the following
actions:

          (i) Optionee or Optionee's representative shall deliver to the Company
     a Notice of Exercise. If the option is exercised by a representative of
     Optionee, the notice shall be accompanied by proof (satisfactory to the
     Company) of the representative's right to exercise this option.

          (ii) Optionee or Optionee's representative shall deliver to the
     Company, at the time of giving the notice, payment in a form permissible
     under Section 5 for the aggregate Exercise Price for the Option Shares
     acquired.

     5. PAYMENT FOR OPTION SHARES. Payment of the Exercise Price for Option
Shares, and withholding taxes due thereon, may be made in one or more of the
following manners:

     (a) Manner of Payment. Payment of the Exercise Price for Option Shares, and
withholding taxes due thereon, may be made in one or more of the following
manners:

          (i) All or any part of the aggregate Exercise Price and applicable
withholding taxes may be paid in cash or cash equivalents delivered together
with the Notice of Exercise.

          (ii) All or any part of the aggregate Exercise Price and applicable
withholding taxes may be paid by surrendering, or attesting to the ownership of,
shares of the Company that

<PAGE>

are already owned by Optionee. Such shares shall be surrendered to the Company
in good form for transfer and shall be valued at their Fair Market Value on the
date when this option is exercised. Optionee shall not surrender, or attest to
the ownership of, shares in payment of the Purchase Price if such action would
cause the Company to recognize compensation expense (or additional compensation
expense) with respect to this option for financial reporting purposes.

          (iii) All or any part of the aggregate Exercise Price and applicable
withholding taxes may be paid through a special sale and remittance procedure
pursuant to which Optionee (or any other person or persons exercising the
option) shall concurrently provide irrevocable instructions (a) to a brokerage
firm approved by the Company to effect the immediate sale of the purchased
Option Shares and remit to the Company, out of the sale proceeds available on
the settlement date, sufficient funds to cover the aggregate Exercise Price
payable for the purchased Option Shares plus all applicable Federal, state and
local income and employment taxes required to be withheld by the Company by
reason of such exercise and (b) to the Company to deliver the certificates for
the purchased Option Shares directly to such brokerage firm in order to complete
the sale.

          (iv) All or any part of the aggregate Exercise Price and applicable
withholding taxes may be paid by the delivery (on a form approved by the
Company) of an irrevocable direction (a) to pledge Option Shares to a securities
broker or lender approved by the Company, as security for a loan, and to deliver
all or part of the loan proceeds to the Company and (b) to the Company to
deliver the certificates for the purchased Option Shares directly to such
brokerage firm in order to complete the transaction.

          (v) Notwithstanding the foregoing, the Company shall not be required
to permit any part of the aggregate Exercise Price or applicable withholding
taxes to be paid by any of the foregoing methods to the extent that such method
would be impermissible under or would violate applicable law and regulations, as
the same now exists or may hereafter be amended.

     (b) Withholding Taxes. In the event that the Company determines that it is
required to withhold any tax as a result of the exercise of this option,
Optionee, as a condition to the exercise of this option, shall make arrangements
satisfactory to the Company to enable it to satisfy all withholding
requirements, including in one or more of the manners set forth above. Optionee
shall also make arrangements satisfactory to the Company to enable it to satisfy
any withholding requirements that may arise in connection with the acquisition
or disposition of Option Shares purchased by exercising this option.

     6. TERMINATION OF SERVICE. The option term specified in Section 3 shall
terminate (and this option shall cease to be outstanding) prior to the
Expiration Date should any of the following provisions become applicable:

     (a) Termination Generally. If Optionee's Service is Terminated for any
reason except death, Disability or for Cause, then Optionee may exercise the
option, only to the extent that the option has vested and is exercisable upon
the Termination Date, and no later than three (3) months after the Termination
Date (or within such shorter time period, not less than thirty (30) days, or
within such longer time period, not exceeding five (5) years, after the
Termination Date as may be determined by the Committee, with any exercise beyond
three (3) months after the Termination Date deemed to be a Nonqualified Option)
but in any event, no later than the expiration date of this option.

                                        2

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     (b) Leave. In the case of any Optionee on (i) sick leave, (ii) military
leave or (iii) on an approved leave of absence, the Committee may make such
provisions as it may deem appropriate respecting suspension of vesting of this
option while leave continues, except that in no event may an Option be exercised
after the expiration of the term set forth in this Agreement.

     (c) Termination on Death or Disability. If Optionee is Terminated because
of Optionee's death or Disability (or Optionee dies within three (3) months
after a Termination other than because of Optionee's Disability or Cause), then
the option may be exercised only to the extent the option has vested and is
exercisable on the Termination Date, and must be exercised by Optionee (or
Optionee's legal representative or designated beneficiary) no later than twelve
(12) months after the Termination Date (or within such shorter time period, not
less than six (6) months, or within such longer time period, not exceeding five
(5) years, after the Termination Date as may be determined by the Committee,
with any exercise beyond (x) three (3) months after the Termination Date when
the Termination is for any reason other than Optionee's death or disability,
within the meaning of Section 22(e)(3) of the Code, or (y) twelve (12) months
after the Termination Date when the Termination is for Optionee's disability,
within the meaning of Section 22(e)(3) of the Code, deemed to be a Nonqualified
Option) but in any event no later than the expiration date of this option.

     (d) Termination for Cause. If Optionee is terminated for Cause, then this
option shall expire on Optionee's Termination Date, or if the Committee
otherwise provides in its sole discretion, at such later time and on such
conditions as are determined by the Committee.

     7. CORPORATE TRANSACTIONS. In the event that the Company engages in a
Corporate Transaction at any time prior to the expiration or exercise in full of
the option granted hereunder:

     (a) Assumption. This option may be assumed, converted or replaced by the
successor corporation (if any) or Parent thereof, which assumption, conversion
or replacement will be binding on Optionee. If this option is assumed in
connection with a Corporate Transaction, then this option shall be appropriately
adjusted, immediately after such Corporate Transaction, to apply to the number
and class of securities which would have been issuable to Optionee upon
consummation of the Corporate Transaction had the option been exercised
immediately prior to such Corporate Transaction, and appropriate adjustments
shall also be made to the Exercise Price, provided the aggregate Exercise Price
shall remain the same.

     (b) Substitution. The successor corporation may substitute equivalent
options or provide alternative value to Optionee with a value substantially
equivalent to that provided to the Company's shareholders in the Corporate
Transaction (after taking into account the existing provisions of this option,
including but not limited to the Exercise Price and the Vesting Schedule).

     (c) Acceleration of Vesting. In the event the successor corporation (if
any) refuses to assume or substitute options or other consideration in
connection with the Corporate Transaction, as provided above, or if there is no
successor corporation, then notwithstanding any other provision in this
Agreement to the contrary, any unvested portion of this option shall
automatically vest in full so that, immediately prior to the effective date of
the Corporate Transaction, this option will become fully exercisable for all of
the Option Shares and may be exercised for any or all of the Option Shares as
fully-vested shares of Common Stock.

                                        3

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     (d) Termination of Option. Immediately following the effective time of the
Corporate Transaction, this option shall terminate and cease to be outstanding,
except to the extent assumed by the successor corporation (or Parent thereof) in
connection with the Corporate Transaction.

     (e) No Restrictions on Corporate Transactions. This Agreement shall not in
any way affect the right of the Company to engage in a Corporate Transaction, to
adjust, reclassify, reorganize or otherwise change its capital or business
structure or to sell or transfer any part of its business or assets.

     8. ADJUSTMENT OF SHARES COVERED BY OPTION. Should any change be made to the
Common Stock by reason of any stock split, stock dividend, recapitalization,
combination of shares, exchange of shares or other change affecting the
outstanding Common Stock as a class without the Company's receipt of
consideration, appropriate adjustments shall be made to (i) the total number
and/or class of securities subject to this option and (ii) the Exercise Price in
order to reflect such change and thereby preclude a dilution or enlargement of
benefits hereunder. In no event shall any such adjustments be made in connection
with the conversion of the Company's preferred stock or warrants into shares of
Common Stock.

     9. ISSUANCE OF CERTIFICATES. As soon as practical after the Exercise Date,
the Company shall issue to or on behalf of Optionee (or any other person or
persons exercising this option) a certificate for the purchased Option Shares,
with the appropriate legends affixed thereto.

     10. RIGHTS AS SHAREHOLDER. The holder of this option shall not have any
stockholder rights with respect to the Option Shares until such person shall
have exercised the option, paid the Exercise Price and become the holder of
record of the purchased Option Shares.

     11. ADDITIONAL PROVISIONS FOR INCENTIVE STOCK OPTIONS. In the event this
option is designated an Incentive Option in the Grant Notice, the following
terms and conditions shall also apply to the grant:

     (a) Time Limitations. This option shall cease to qualify for favorable tax
treatment as an Incentive Option if (and to the extent) this option is exercised
for one or more Option Shares: (i) more than three (3) months after the date
Optionee ceases to be an Employee for any reason other than death or Disability
or (ii) more than twelve (12) months after the date Optionee ceases to be an
Employee by reason of Disability.

     (b) Volume Limitations. This option shall not become exercisable in the
calendar year in which granted if (and to the extent) the aggregate Fair Market
Value (determined at the Grant Date) of the Common Stock for which this option
would otherwise first become exercisable in such calendar year would, when added
to the aggregate value (determined as of the respective date or dates of grant)
of the Common Stock and any other securities for which one or more other
Incentive Options granted to Optionee prior to the Grant Date (whether under the
Plan or any other option plan of the Company or any Parent or Subsidiary) first
become exercisable during the same calendar year, exceed One Hundred Thousand
Dollars ($100,000) in the aggregate. To the extent the exercisability of this
option is deferred by reason of the foregoing limitation, the deferred portion
shall become exercisable in the first calendar year or years thereafter in which
the One Hundred Thousand Dollar ($100,000) limitation of this Section 11(b)
would not be contravened, but such deferral shall in all events end immediately
prior to the

                                        4

<PAGE>

effective date of a Corporate Transaction in which this option is not to be
assumed, whereupon the option shall become immediately exercisable as a
Nonqualified Option for the deferred portion of the Option Shares.

     (c) Order of Application. Should Optionee hold, in addition to this option,
one or more other options to purchase Common Stock which become exercisable for
the first time in the same calendar year as this option, then the foregoing
limitations on the exercisability of such options as Incentive Options shall be
applied on the basis of the order in which such options are granted.

     12.  RESTRICTIONS ON TRANSFER.

     (a) Restrictions on Transfer of Option. This option, and any interest
herein, is not transferable or assignable by Optionee, and may not be made
subject to execution, attachment or similar process, otherwise than by will or
by the laws of descent and distribution. During the lifetime of Optionee this
option will be exercisable only by Optionee or his or her designated
representative acting on Optionee's behalf, and only Optionee or such designated
representative may make any elections with respect to this option. Optionee may,
by written notice to the Committee, designate a beneficiary (which may be a
person or a trust) to exercise the rights of Optionee upon the death of
Optionee. A beneficiary, guardian, legal representative or other person claiming
any rights under this option from or through Optionee shall be subject to all
terms and conditions of the Plan and this Agreement applicable to Optionee.

     (b) Securities Law Restrictions. Regardless of whether the offering and
sale of Option Shares have been registered under the Securities Act or have been
registered or qualified under the securities laws of any state, the Company at
its discretion may impose restrictions upon the sale, pledge or other transfer
of such Option Shares (including the placement of appropriate legends on stock
certificates or the imposition of stop-transfer instructions) if, in the
judgment of the Company, such restrictions are necessary or desirable in order
to achieve compliance with the Securities Act, the securities laws of any state
or any other law. Notwithstanding any other provision in this Agreement or the
Plan, the Company will have no obligation to issue or deliver certificates for
Option Shares prior to (i) obtaining any approvals from governmental agencies
that the Company determines are necessary or advisable, and/or (ii) compliance
with any exemption or completion of any registration or other qualification of
such Option Shares under any state or federal law or ruling of any governmental
body that the Company determines to be necessary or advisable. The Company will
be under no obligation to register the Option Shares with the SEC or to effect
compliance with the exemption, registration, qualification or listing
requirements of any state securities laws, stock exchange or automated quotation
system, or take any other steps as may be necessary to enable the Option Shares
to be offered and sold or resold under federal or other securities laws, and the
Company will have no liability for any inability or failure to do so.

     (c) Investment Intent at Grant. Optionee represents and agrees that this
option and the Option Shares to be acquired upon exercising this option are or
will be acquired for investment, and not with a view to the sale or distribution
thereof.

     (d) Investment Intent at Exercise. In the event that the sale of Option
Shares is not registered under the Securities Act but an exemption is available
which requires an investment representation or other representation, Optionee
shall represent and agree at the time of exercise that the Option Shares being
acquired upon exercising this option are being acquired for

                                       5

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investment, and not with a view to the sale or distribution thereof, and shall
make such other representations as are deemed necessary or appropriate by the
Company and its counsel.

     (e) Legends. All certificates evidencing Option Shares shall bear the
following legend:

     THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
     ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAW AND MAY NOT BE SOLD,
     PLEDGED, OR OTHERWISE TRANSFERRED UNLESS THEY ARE FIRST REGISTERED UNDER
     ALL SUCH APPLICABLE ACTS OR THE COMPANY RECEIVES AN OPINION OF COUNSEL,
     SATISFACTORY IN FORM AND SUBSTANCE TO THE COMPANY AND ITS COUNSEL, THAT
     SUCH TRANSFER MAY BE MADE WITHOUT REGISTRATION.

     (f) Removal of Legends. If, in the opinion of the Company and its counsel,
any legend placed on a stock certificate representing Option Shares is no longer
required, the holder of such certificate shall be entitled to exchange such
certificate for a certificate representing the same number of Option Shares but
without such legend.

     (g) Administration. Any determination by the Company and its counsel in
connection with any of the matters set forth in this Section 12 shall be
conclusive and binding on Optionee and all other persons.

                                       6

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                                   APPENDIX A

The following definitions shall be in effect under the Agreement:

     A. 1934 Act means the Securities Exchange Act of 1934, as amended.

     B. Agreement means this Stock Option Grant Agreement.

     C. Board means the Company's Board of Directors.

     D. Cause means Termination because of (i) any willful material violation by
Optionee of any law or regulation applicable to the business of the Company,
(ii) Optionee's conviction of, or plea of nolo contendere or guilty with respect
to, a felony or a crime involving moral turpitude, (iii) any willful
perpetration by Optionee of a common law fraud, (iv) Optionee's commission of an
act of personal dishonesty which involves personal profit in connection with the
Company or any other entity having a business relationship with the Company (v)
any material breach by Optionee of any provision of any agreement or
understanding between the Company and Optionee regarding the terms of Optionee's
Service, including without limitation, the willful and continued failure or
refusal of Optionee to perform the material duties required of such Optionee as
an employee, director or consultant of the Company, other than as a result of
having a Disability, (vi) any unauthorized use or disclosure by Optionee of
confidential information or trade secrets of the Company (or any Parent or
Subsidiary) or a breach of any applicable invention assignment and
confidentiality agreement or similar agreement between the Company and Optionee,
(vi) Optionee's disregard of the policies of the Company so as to cause loss,
damage or injury to the property, reputation or employees of the Company, or
(vii) any other misconduct by Optionee which is materially injurious to the
financial condition or business reputation of, or is otherwise materially
injurious to, the Company.

     E. Code means the Internal Revenue Code of 1986, as amended.

     F. Committee means the committee appointed by the Board to administer the
Plan, or if no committee is appointed, the Board.

     G. Common Stock means the Company's common stock, par value $0.01 per
share.

     H. Company means Quatrx Pharmaceuticals Company, a Delaware corporation.

     I. Corporate Transaction means any of the following stockholder-approved
transactions to which the Company is a party:

          i. A dissolution or liquidation of the Company.

          ii. A merger or consolidation in which the Company is not the
     surviving corporation (other than a merger or consolidation with a
     wholly-owned Subsidiary, a reincorporation of the Company in a different
     jurisdiction, or other transaction in which there is no substantial change
     in the shareholders of the Company or their relative stock holdings and the
     option granted under this Agreement are assumed, converted or replaced by
     the successor corporation, which assumption, conversion or replacement will
     be binding on Optionee).

<PAGE>

          iii. A merger in which the Company is the surviving corporation but
     after which the shareholders of the Company immediately prior to such
     merger (other than any shareholder which merges with the Company in such
     merger, or which owns or controls another corporation which merges, with
     the Company in such merger) cease to own their shares or other equity
     interests in the Company.

          iv. The sale of all or substantially all of the assets of the Company,

     J. Disability means a disability, whether temporary or permanent, partial
or total, physical, emotional or other, pursuant to which Optionee's Service has
been terminated.

     K. Employee means an individual who is in the employ of the Company (or any
Parent or Subsidiary), subject to the control and direction of the employer
entity as to both the work to be performed and the manner and method of
performance.

     L. Exercise Date means the date on which Optionee shall have taken all
steps required to exercise the option in accordance with Section 4 of the
Agreement.

     M. Exercise Price means the exercise price payable per Option Share as
specified in the Grant Notice.

     N. Expiration Date means the date on which the option expires as specified
in the Grant Notice.

     O. Fair Market Value per share of Common Stock on any relevant date shall
be determined in accordance with the following provisions:

     a. If the Common Stock is at the time traded on the Nasdaq National Market,
then the Fair Market Value shall be the closing selling price per share of
Common Stock on the date in question, as the price is reported by the National
Association of Securities Dealers on the Nasdaq National Market. If there is no
closing selling price for the Common Stock on the date in question, then the
Fair Market Value shall be the closing selling price on the last preceding date
for which such quotation exists.

     b. If the Common Stock is at the time listed on any Stock Exchange, then
the Fair Market Value shall be the closing selling price per share of Common
Stock on the date in question on the Stock Exchange determined by the Committee
to be the primary market for the Common Stock, as such price is officially
quoted in the composite tape of transactions on such exchange. If there is no
closing selling price for the Common Stock on the date in question, then the
Fair Market Value shall be the closing selling price on the last preceding date
for which such quotation exists.

     c. If the Common Stock is at the time neither listed on any Stock Exchange
nor traded on the Nasdaq National Market, then the Fair Market Value shall be
determined by the Committee after taking into account such factors as the
Committee shall deem appropriate.

     P. Grant Date means the date of grant of the option as specified in the
Grant Notice.

     Q. Grant Notice means the Stock Option Grant Notice attached to and made
part of this Agreement, pursuant to which Optionee has been informed of the
basic terms of the option evidenced hereby.

                                       A-2

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     R. Incentive Option means an option which satisfies the requirements of
Code Section 422.

     S. Nonqualified Option means an option not intended to satisfy the
requirements of Code Section 422.

     T. Notice of Exercise means a written notice to the Company pursuant to
Section 4 that specifies the election to exercise the option, the number of
Option Shares for which it is being exercised and the form of payment. The
notice shall be signed by the person exercising this option. In the event that
this option is being exercised by the representative of Optionee, the notice
shall be accompanied by proof (satisfactory to the Company) of the
representative's right to exercise this option.

     U. Option Shares means the number of shares of Common Stock subject to the
option.

     V. Optionee means the person to whom the option is granted as specified in
the Grant Notice.

     W. Parent means any corporation (other than the Company) in an unbroken
chain of corporations ending with the Company, provided each corporation in the
unbroken chain (other than the Company) owns, at the time of the determination,
stock possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock in one of the other corporations in such chain.

     X. Plan means the Company's 2000 Equity Incentive Plan.

     Y. Service means Optionee's performance of services for the Company (or any
Parent or Subsidiary) in the capacity of an Employee, a non-employee member of
the board of directors or an independent consultant.

     Z. Stock Exchange means the American Stock Exchange or the New York Stock
Exchange.

     AA. Subsidiary means any corporation (other than the Company) in an
unbroken chain of corporations beginning with the Company, provided each
corporation (other than the last corporation) in the unbroken chain owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     BB. "Termination" or "Terminated" means that Optionee has for any reason
ceased to provide Service. An Optionee will not be deemed to have ceased to
provide Service in the case of (i) sick leave, (ii) military leave, or (iii) any
other leave of absence approved by the Committee, provided that such leave is
for a period of not more than ninety (90) days unless reinstatement (or, in the
case of an employee with an ISO, reemployment) upon the expiration of such leave
is guaranteed by contract or statute, or unless provided otherwise pursuant to
formal policy adopted from time to time by the Company and issued and
promulgated in writing. The Committee will have sole discretion to determine
whether an Optionee has ceased to provide Service and the effective date on
which Optionee ceased to provide Service (the "Termination Date").

                                       A-3

<PAGE>

     CC. Vesting Schedule means the vesting schedule specified in the Grant
Notice pursuant to which Optionee has the right to exercise the option to
acquire Option Shares in one or more installments over his or her period of
Service.

                                       A-4<PAGE>
                                                                    Exhibit 10.5

                                  OFFICE LEASE

                                     BETWEEN

                TRANSWESTERN GREAT LAKES REIT, L.P., AS LANDLORD

                                       AND

                    QUATRX PHARMACEUTICALS COMPANY, AS TENANT

                              777 EISENHOWER PLAZA
                           777 EAST EISENHOWER PARKWAY
                               ANN ARBOR, MICHIGAN

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                            PAGE
                                                                            ----
<S>                                                                         <C>
1.  DEFINITIONS .........................................................     1
2.  LEASE GRANT/POSSESSION ..............................................     4
3.  USE .................................................................     5
4.  RENT ................................................................     5
5.  SECURITY DEPOSIT ....................................................     6
6.  SERVICES TO BE FURNISHED BY LANDLORD ................................     6
7.  LEASEHOLD IMPROVEMENTS; TENANT'S PROPERTY ...........................     7
8.  SIGNAGE .............................................................     8
9.  MAINTENANCE, REPAIRS AND ALTERATIONS ................................     8
10. USE OF ELECTRICAL SERVICES BY TENANT ................................     9
11. ASSIGNMENT AND SUBLETTING ...........................................     9
12. MECHANIC'S LIENS ....................................................    11
13. INSURANCE ...........................................................    11
14. INDEMNITY ...........................................................    12
15. DAMAGES FROM CERTAIN CAUSES .........................................    13
16. CASUALTY DAMAGE .....................................................    13
17. CONDEMNATION ........................................................    14
18. EVENTS OF DEFAULT ...................................................    14
19. REMEDIES ............................................................    15
20. NO WAIVER ...........................................................    17
21. PEACEFUL ENJOYMENT ..................................................    17
22. SUBSTITUTION ........................................................    17
23. HOLDING OVER ........................................................    18
</TABLE>

                                        i

<PAGE>

<TABLE>
<S>                                                                          <C>
24. SUBORDINATION TO MORTGAGE; ESTOPPEL CERTIFICATE .....................    18
25. NOTICE ..............................................................    19
26. SURRENDER OF PREMISES ...............................................    19
27. RIGHTS RESERVED TO LANDLORD .........................................    19
28. MISCELLANEOUS........................................................    20
29. NO OFFER ............................................................    21
30. ENTIRE AGREEMENT ....................................................    21
31. LIMITATION OF LIABILITY .............................................    22
</TABLE>

EXHIBIT A - OUTLINE AND LOCATION OF PREMISES
EXHIBIT B - RULES AND REGULATIONS
EXHIBIT C - PAYMENT OF BASIC COSTS
EXHIBIT D - WORK LETTER
EXHIBIT E - ADDITIONAL PROVISIONS
EXHIBIT F - COMMENCEMENT LETTER

                                       ii

<PAGE>

                                  OFFICE LEASE

     This Office Lease (the "Lease") is made and entered into on this the 11th
day of November, 2004, between TRANS WESTERN GREAT LAKES, L.P., a Delaware
limited partnership ("LANDLORD"), and QUATRX PHARMACEUTICALS COMPANY, a
_________________________ ("TENANT").

                                   WITNESSETH:

     1. DEFINITIONS. The following are definitions of some of the defined terms
used in this Lease. The definition of other defined terms are found throughout
this Lease.

          A. "BUILDING" SHALL mean the office building at 777 East Eisenhower
     Parkway, Ann Arbor, Michigan, currently known as 777 Eisenhower Plaza.

          B. "BASE RENT": Base Rent shall be paid according to the following
     schedule, subject to the provisions of Section 4 hereof. For the purposes
     of this Section 1B, "Lease Year" shall mean the twelve (12) month period
     commencing on the Commencement Date, and on each anniversary of the
     Commencement Date (or portion thereof ending on the Expiration Date).

<TABLE>
<CAPTION>
                  ANNUAL     MONTHLY INSTALLMENTS
   PERIOD       BASE RENT        OF BASE RENT
------------   -----------   --------------------
<S>            <C>           <C>
MONTHS 1-3     $      0.00        $     0.00
MONTHS 4-15    $130,341.12        $10,861.76
MONTHS 16-27   $133,325.12        $11,110.43
MONTHS 28-39   $136,309.12        $11,359.09
MONTHS 40-51   $139,293.12        $11,607.76
MONTHS 52-63   $142,277.12        $11,856.43
MONTHS 64-75   $145,261.12        $12,105.09
</TABLE>

The Base Rent and Additional Rent due for the fourth month during the Lease Term
(hereinafter defined) shall be paid by Tenant to Landlord contemporaneously with
Tenant's execution hereof.

          C. "ADDITIONAL RENT" shall mean Tenant's Pro Rata Share of Basic Costs
     (hereinafter defined) and Tenant's Pro Rata Share of Taxes (hereinafter
     defined) and any other slims (exclusive of Base Rent) that are required to
     be paid to Landlord by Tenant hereunder, which sums are deemed to be
     Additional Rent under this Lease.

          D. "BASIC COSTS" is defined in Exhibit C attached hereto.

                                       1

<PAGE>

          E. "TAXES" is defined in Exhibit C attached hereto.

          F. "SECURITY DEPOSIT" shall mean a letter of credit in the amount of
     One Hundred Twenty Thousand and 00/100 Dollars ($120,000.00), subject to
     the terms set forth in Exhibit E. The Security Deposit shall be paid by
     Tenant to Landlord contemporaneously with Tenant's execution hereof.

          G. "LEASE TERM" shall mean a period of Seventy Five (75) months
     commencing on the date upon which Landlord's Work in the Premises has been
     substantially completed, as such date is determined pursuant to the Work
     Letter attached hereto as EXHIBIT D (the later to occur of such dates being
     defined as the "COMMENCEMENT DATE"). Landlord shall make a good faith
     effort to substantially complete Landlord's Work in the Premises by
     December 15, 2005 (THE "TARGET COMMENCEMENT DATE"). "EXPIRATION DATE" SHALL
     MEAN the last day of the Lease Term. Notwithstanding the foregoing, if the
     Expiration Date, as determined herein, does not occur on the last day of a
     calendar month, the Lease Term and the last Lease Year thereof shall be
     extended by the number of days necessary to cause the Expiration Date to
     occur on the last day of the last calendar month of the Lease Term. Tenant
     shall pay Base Rent and Additional Rent for such additional days at the
     same rate payable for the portion of the last calendar month immediately
     preceding such extension. Upon the determination of the actual Commencement
     Date and the actual Expiration Date, Landlord and Tenant shall each execute
     and deliver a Commencement Letter in the form of Exhibit F attached hereto.

          H. "PREMISES" shall mean the office space located within the Building
     and outlined on EXHIBIT A to this Lease, and commonly referred to as Suite
     100. If the Premises include one or more floors in their entirety, all
     corridors and restroom facilities located on such full floor(s) shall be
     considered part of the Premises.

          I. "RENTABLE AREA IN THE PREMISES" shall mean 5,968 square feet.

          J. "RENTABLE AREA IN THE BUILDING" shall mean 281,080 square feet.

          K. "TENANT'S PRO RATA SHARE" shall mean Two and 12/100 percent
     (2.12%).

          L. "PERMITTED USE" shall mean general office use and no other use or
     purpose.

          M. "BASE YEAR" shall mean 2004.

          N. "GUARANTOR(S)" shall mean NONE.

          O. "BROKER" shall mean, collectively, Friedman Real Estate Group and
     Transwestern Commercial Services.

          P. "BUSINESS DAY(S)" shall mean Mondays through Fridays exclusive of
     the normal business holidays.

          Q. "COMMON Areas" shall mean those areas located within the Building
     or on the Property designated by Landlord, from time to time, for the
     common use or benefit of

                                       2

<PAGE>

     tenants generally and/or the public.

          R. "DEFAULT RATE" shall mean the lower of (i) fifteen percent per
     annum, or (ii) the highest rate of interest from time-to-time permitted
     under applicable federal and state law.

          S. "NORMAL BUSINESS HOURS" for the Building shall mean 8:00 a.m. to
     6:00 p.m. Mondays through Fridays, and 8:00 a.m. to 1:00 p.m. on Saturdays,
     exclusive of holidays.

          T. "PROPERTY" shall mean the Building and the parcel(s) of land on
     which it is located, other improvements located on such land, adjacent
     parcels of land that Landlord operates jointly with the Building, and other
     buildings and improvements located on such adjacent parcels of land.

          U. "NOTICE ADDRESSES" shall mean the following addresses for Tenant
     and Landlord, respectively:

               Tenant:
               QUATRx Pharmaceuticals Company
               777 East Eisenhower Parkway, Suite 100
               Ann Arbor, Michigan 48108

               Landlord:
               Transwestern Commercial Services
               777 East Eisenhower Parkway, Suite 136
               Ann Arbor, Michigan 48108
               Attn: Property Manager

               with a copy to:

               Transwestern Investment Company
               150 North Wacker Drive, Suite 800
               Chicago, Illinois 60606
               Attn: Owner's Representative

               and to:

               Drane, Freyer and Lapins
               150 North Wacker Drive, 8th Floor
               Chicago, Illinois 60606
               Attn: Wendy Freyer, Esq.

               Payments of Rent only shall be made payable to the order of:

                                       3

<PAGE>

               Transwestern 777 Eisenhower Plaza at the following address:

               Transwestern Commercial Services
               777 East Eisenhower Parkway, Suite 136
               Ann Arbor, Michigan 48108
               Attn: Property Manager

               or such other name and address as Landlord shall, from time to
               time, designate.

     2. LEASE GRANT/POSSESSION.

          A. Subject to and upon the terms herein set forth, Landlord leases to
     Tenant and Tenant leases from Landlord the Premises on an "as is" basis
     (except as otherwise expressly set forth herein), together with the right,
     in common with others, to use the Common Areas. By taking possession of the
     Premises, Tenant is deemed to have accepted the Premises and agreed that
     the Premises is in good order and satisfactory condition, with no
     representation or warranty by Landlord as to the condition of the Premises
     or the Building or suitability thereof for Tenant's use. Tenant, and its
     employees, guests and invitees, shall have the non-exclusive right to use
     up to 3.76 parking spaces per one thousand (1,000) rentable square feet of
     space in the Premises in the surface parking spaces (except the reserved or
     designated parking spaces) in the parking area adjacent to the Building
     free of charge during the term of the Lease.

          B. Notwithstanding anything to the contrary contained in this Lease,
     if Landlord is unable to tender possession of any portion of the Premises
     on the date possession is to be delivered due to the holding over of
     another party, this Lease shall not be void or voidable or otherwise
     affected and Tenant shall have no claim for damages against Landlord.
     Landlord shall use reasonable efforts to regain possession of the Premises
     in order to deliver the same to Tenant. If the Commencement Date as set
     forth in Section 1G is a specified date, the Commencement Date shall be
     postponed until the date Landlord delivers possession of the Premises to
     Tenant, the Expiration Date shall, at the option of Landlord,
     correspondingly be postponed on a per diem basis, and, upon the
     determination of the actual Commencement Date and the actual Expiration
     Date, Landlord and Tenant shall each execute and deliver a Commencement
     Letter in the form of Exhibit F attached hereto.

          Notwithstanding the foregoing, if Landlord has not substantially
     completed the Landlord's Work in the Premises by May 1, 2005, for any
     reason other than a Tenant Delay or Force Majeure, then Tenant shall have
     the right to terminate this Lease upon written notice received by Landlord
     by May 10, 2005.

          C. If Tenant, with Landlord's prior written approval, takes possession
     of the Premises prior to the Commencement Date for the sole purpose of
     performing any improvements therein or installing furniture, equipment or
     other personal property of Tenant, such possession shall be subject to all
     of the terms and conditions of this Lease,

                                       4

<PAGE>

     except that Tenant shall not be required to pay Rent with respect to the
     period of time prior to the Commencement Date during which Tenant performs
     such work. Tenant shall, however, be liable for the reasonable cost of any
     services (e.g., electricity, HVAC, freight elevators) that are provided to
     Tenant during the period of Tenant's possession prior to the Commencement
     Date. Nothing herein shall be construed as granting Tenant the right to
     take possession of the Premises prior to the Commencement Date, whether for
     construction, fixturing or any other purpose, without the prior written
     consent of Landlord.

     3. USE. The Premises shall be used for the Permitted Use and for no other
purpose. Tenant agrees not to use or permit the use of the Premises for any
purpose which is illegal or dangerous, which creates a nuisance or which would
increase the cost of insurance coverage with respect to the Building. Tenant
will conduct its business and control its agents, servants, employees,
customers, licensees, and invitees in such a manner as not to interfere with or
disturb other tenants or Landlord in the management of the Property. Tenant will
maintain the Premises in a clean and healthful condition, and comply with all
laws, ordinances, orders, rules and regulations of any governmental entity with
reference to the use, condition, configuration or occupancy of the Premises.
Tenant shall not, and shall not allow its employees, agents, contractors or
invitees, to bring into the Building or the Premises any dangerous or hazardous
materials, except for customary office and cleaning supplies, provided Tenant
uses, stores and disposes of the same in compliance with all applicable law.
Tenant, at its expense, will comply with the rules and regulations of the
Building attached hereto as EXHIBIT B and such other rules and regulations
adopted and altered by Landlord from time-to-time and will cause all of its
agents, employees, invitees and visitors to do so. All such changes to rules and
regulations will be reasonable and shall be sent by Landlord to Tenant in
writing. In the event of a conflict between the rules and regulations and the
terms of this Lease, the terms of this Lease shall control. Landlord shall not
knowingly enforce the rules and regulations against Tenant in a discriminatory
manner.

     4. RENT.

          A. Tenant covenants to pay to Landlord during the Lease Term, without
     any setoff or deduction except as otherwise expressly provided herein, the
     full amount of all Base Rent and Additional Rent due hereunder and the full
     amount of all such other sums of money as shall become due under this
     Lease, all of which hereinafter. may be collectively called "Rent." In
     addition, Tenant shall pay, as Additional Rent, all rent, sales and use
     taxes or other similar taxes, if any, levied or imposed by any city, state,
     county or other governmental body having authority, such payments to be in
     addition to all other payments required to be paid to Landlord by Tenant
     under this Lease. Such payments shall be paid concurrently with the
     payments of the Rent on which the tax is based. Base Rent and Additional
     Rent for each calendar year or portion thereof during the Lease Term, shall
     be due and payable in advance in monthly installments on the first day of
     each calendar month during the Lease Term, without demand. If the Lease
     Term commences on a day other than the first day of a month or terminates
     on a day other than the last day of a month, then the installments of Base
     Rent and Additional Rent for such month or months shall be prorated, based
     on the number of days in such month. All amounts received by Landlord from
     Tenant hereunder shall be applied first to the earliest accrued

                                       5

<PAGE>

     and unpaid Rent then outstanding. Tenant's covenant to pay Rent shall be
     independent of every other covenant set forth in this Lease.

          B. If Tenant fails to pay any installment of Base Rent and Additional
     Rent or any other item of Rent when due and payable hereunder, a "LATE
     CHARGE" equal to five percent (5%) of such unpaid amount will be due and
     payable immediately by Tenant to Landlord.

          C. The Additional Rent payable hereunder shall be adjusted from
     time-to-time in accordance with the provisions of EXHIBIT C attached
     hereto.

     5. Security Deposit. The Security Deposit shall be held by Landlord without
liability for interest and as security for the performance by Tenant of Tenant's
covenants and obligations under this Lease, it being expressly understood that
the Security Deposit shall not be considered an advance payment of Rent or a
measure of Tenant's liability for damages in case of default by Tenant. Landlord
shall not be required to keep the Security Deposit separate from its other
accounts, shall have no fiduciary responsibilities or trust obligations
whatsoever with regard to the Security Deposit. Landlord may, from time-to-time,
without prejudice to any other remedy and without waiving such default, use the
Security Deposit to the extent necessary to cure or attempt to cure, in whole or
in part, any default of Tenant hereunder. Following any such application of the
Security Deposit, Tenant shall pay to Landlord within five (5) days after demand
the amount so applied in order to restore the Security Deposit to its original
amount. If Tenant is not in default at the termination of this Lease, the
balance of the Security Deposit remaining after any such application shall be
returned by Landlord to Tenant within sixty (60) days thereafter. If Landlord
transfers its interest in the Premises during the Lease Term, Landlord shall
assign the Security Deposit to the transferee and thereafter shall have no
further liability for the return of such Security Deposit.

     6. SERVICES TO BE FURNISHED BY LANDLORD.

          A. Landlord shall furnish the following services: (i) heating and air
     conditioning during Normal Business Hours to provide a temperature
     condition required, in Landlord's reasonable judgment, for comfortable
     occupancy of the Premises under normal business operations; (ii) water for
     drinking, and, subject to Landlord's approval, water at Tenant's expense
     for any private restrooms and office kitchen requested by Tenant; (iii)
     janitorial service in the Premises and Common Areas on Business Days; (iv)
     electricity to the Premises for general office use, in accordance with and
     subject to the terms and conditions of Section 10 of this Lease and (v)
     passenger elevator service, 24 hours a day, 7 days a week; and freight
     elevator service on Business Days, upon request of Tenant and subject to
     scheduling and charges by Landlord.

          B. If Tenant requests any other utilities or building services in
     addition to those identified in Section 6A, or any of the above utilities
     or building services in frequency, scope, quality or quantities
     substantially greater than the standards set by Landlord for the Building,
     then Landlord shall use reasonable efforts to attempt to furnish Tenant
     with such additional utilities or building services. Landlord may impose a

                                       6

<PAGE>

     reasonable charge for such additional utilities or building services, which
     shall be paid monthly by Tenant as Additional Rent on the same day that the
     monthly installment of Base Rent is due.

          C. Except as otherwise expressly provided herein, the failure by
     Landlord to any extent to furnish, or the interruption or termination of
     utilities and Building services identified in Section 6A in whole or in
     part, resulting from adherence to laws, regulations and administrative
     orders, wear, use, repairs, improvements, alterations or any causes shall
     not render Landlord liable in any respect nor be construed as an actual or
     constructive eviction of Tenant, nor give rise to an abatement of Rent, nor
     relieve Tenant from the obligation to fulfill any covenant or agreement
     hereof.

          D. Notwithstanding anything to the contrary contained in this Section
     6, if: (i) Landlord ceases to furnish any service in the Building for a
     period in excess of five (5) consecutive Business Days after Tenant
     notifies Landlord of such cessation (the "INTERRUPTION NOTICE"); (ii) such
     cessation does not arise as a result of an act or omission of Tenant; (iii)
     such cessation is not caused by a fire or other casualty (in which case
     Section 16 shall control); (iv) the restoration of such service is
     reasonably within the control of Landlord; and (v) as a result of such
     cessation, the Premises or a material portion thereof, is rendered
     untenantable and Tenant in fact ceases to use the Premises, or material
     portion thereof, then Tenant, as its sole remedy, shall be entitled to
     receive an abatement of Base Rent payable hereunder during the period
     beginning on the sixth (6th) consecutive Business Day of such cessation and
     ending on the day when the service in question has been restored. In the
     event the entire Premises has not been rendered untenantable by the
     cessation in service, the amount of abatement that Tenant is entitled to
     receive shall be prorated based upon the percentage of the Premises so
     rendered untenantable and not used by Tenant.

     7. LEASEHOLD IMPROVEMENTS: TENANT'S PROPERTY. All fixtures, equipment,
improvements and appurtenances attached to, or built into, the Premises at the
commencement of or during the Lease Term, whether or not by, or at the expense
of, Tenant ("LEASEHOLD IMPROVEMENTS"), shall be and remain a part of the
Premises, shall be the property of Landlord, and shall not be removed by Tenant
except as expressly provided herein. All unattached and moveable partitions,
trade fixtures, moveable equipment or furniture located in the Premises and
acquired by or for the account of Tenant, without expense to Landlord, which can
be removed without structural damage to the Building or Premises, and all
personalty brought into the Premises by TENANT ("TENANT'S PROPERTY") shall be
owned and insured by Tenant. Landlord may, nonetheless, within one (1) month
after, the expiration or earlier termination of this Lease or Tenant's right to
possession of the Premises, require Tenant to remove any Leasehold Improvements,
except those Leasehold Improvements installed pursuant to the Plans referenced
in the Work Letter attached hereto as Exhibit D (the "REQUIRED REMOVABLES") at
Tenant's sole cost. Upon the termination of the Lease Term or the sooner
termination of Tenant's right to possession of the Premises, Tenant shall remove
Tenant's Property, all electronic, phone and data cabling exclusively serving
the Premises (whether such cabling is located within or outside of the
Premises), and all Required Removables. Tenant shall, at its sole cost and
expense, repair any damage caused by such removal and perform such other work as
is reasonably necessary to

                                       7

<PAGE>

restore the Premises to a "move in" condition. If Tenant fails to remove any of
the foregoing items or to perform any required repairs and restoration, (i)
Landlord, at Tenant's sole cost and expense, may remove the same (and repair any
damage occasioned thereby) and dispose thereof or deliver such items to any
other place of business of Tenant, or warehouse the same, and Tenant shall pay
the cost of such removal, repair, delivery, or warehousing of such items within
five (5) days after demand from Landlord and (ii) such failure shall be deemed a
holding over by Tenant under Section 23 hereof until such failure is rectified
by Tenant or Landlord.

     8. SIGNAGE. Tenant shall not install any signage visible from the exterior
of the Premises; all signage shall be in the standard graphics for the Building
and no others shall be used or permitted without Landlord's prior written
consent. Landlord will install Building standard suite and Building directory
signage identifying Tenant, the cost of which will be deducted from the Tenant
Allowance described in Exhibit D attached hereto.

     9. MAINTENANCE, REPAIRS AND ALTERATIONS.

          A. Except to the extent such obligations are imposed upon Landlord
     hereunder, Tenant shall, at its sole cost and expense, maintain the
     Premises in good order, condition and repair throughout the entire Lease
     Term, ordinary wear and tear excepted. Tenant agrees to keep the areas
     visible from outside the Premises in a neat, clean and attractive condition
     at all times. Tenant shall, within thirty (30) days after Landlord's
     written demand therefor, reimburse Landlord for the cost of all repairs,
     replacements and alterations (collectively, "Repairs") in and to the
     Premises, Building and Property and the facilities and systems thereof,
     plus an administration charge of ten percent of such cost, the need for
     which Repairs arises out of (1) Tenant's use or occupancy of the. Premises,
     (2) the installation, removal, use or operation of Tenant's Property or
     Required Removables, (3) the moving of Tenant's Property and Required
     Removables into or out of the Building, (4) any Alterations (hereinafter
     defined) or other work performed by Landlord pursuant to the Work Letter
     (subject to any construction allowance), or (5) the act, omission, misuse
     or negligence of Tenant, its agents, contractors, employees or invitees.
     Landlord shall be responsible for the performance of all other Building
     repairs.

          B. Tenant shall not make or allow to be made any alterations,
     additions or improvements to the Premises (collectively, "ALTERATIONS"),
     without first obtaining the written consent of Landlord. Prior to
     commencing any Alterations and as a condition to obtaining Landlord's
     consent, Tenant shall deliver to Landlord plans and specifications
     acceptable to Landlord; names and addresses of contractors reasonably
     acceptable to Landlord; copies of contracts; necessary permits and
     approvals; evidence of contractor's and subcontractor's insurance in
     accordance with Section 13 hereof; and a payment bond or other security,
     all in form and amount satisfactory to Landlord. Tenant shall be
     responsible for insuring that all such persons procure and maintain
     insurance coverage against . such risks, in such amounts and with such
     companies as Landlord may reasonably require. All Alterations shall be
     constructed in a good and workmanlike manner using Building standard
     materials or other new materials of equal or greater quality. Landlord, to
     the extent reasonably necessary to avoid any disruption to the

                                       8

<PAGE>

     tenants and occupants of the Building, shall have the right to designate
     the time when any Alterations may be performed and to otherwise designate
     reasonable rules, regulations and procedures for the performance of work in
     the Building. Upon completion of the Alterations, Tenant shall deliver to
     Landlord "as-built" plans, contractor's affidavits and full and final
     waivers of lien and receipted bills covering all labor and materials. All
     Alterations shall comply with the insurance requirements and with
     applicable codes, ordinances, laws and regulations. Tenant shall reimburse
     Landlord upon demand for all reasonable sums, if any, expended by Landlord
     for third party examination of the architectural, mechanical, electrical
     and plumbing plans for any Alterations. In addition, if Landlord so
     requests, Landlord shall be entitled to oversee the construction of any
     Alterations that may affect the structure of the Building or any of the
     mechanical, electrical, plumbing or life safety systems of the Building. If
     Landlord elects to oversee such work, Landlord shall be entitled to receive
     a fee for such oversight in an amount equal to ten percent (10%) of the
     cost of such Alterations. Landlord's approval of Tenant's plans and
     specifications for any Alterations performed for or on behalf of Tenant
     shall not be deemed to be representation by Landlord that such plans and
     specifications comply with applicable insurance requirements, building
     codes, ordinances, laws or regulations or that the Alterations constructed
     in accordance with such plans and specifications will be adequate for
     Tenant's use.

     10. USE OF ELECTRICAL SERVICES BY TENANT. All electricity used by Tenant in
the Premises shall, at Landlord's option, be paid for by Tenant by a separate
charge billed directly to Tenant by Landlord and payable by Tenant as Additional
Rent within thirty (30) days after billing. Landlord shall have the right at any
time and from time-to-time during the Lease Term to contract for electricity
service from such providers of such services as Landlord shall elect (each being
an "ELECTRIC SERVICE PROVIDER"). Tenant shall cooperate with Landlord, and the
applicable Electric Service Provider, at all times and, as reasonably necessary,
shall allow Landlord and such Electric Service Provider reasonable access to the
Building's electric lines, feeders, risers, wiring, and any other machinery
within the Premises. Tenant's use of electrical services furnished by Landlord
shall not exceed in voltage, rated capacity, or overall load that which is
standard for the Building. In the event Tenant shall request that it be allowed
to consume electrical services in excess of Building standard, Landlord may
refuse to consent to such usage or may consent upon such conditions as Landlord
reasonably elects, and all such additional usage shall be paid for by Tenant as
Additional Rent. Landlord, at any time during the Lease Term, shall have the
right to separately meter electrical usage for the Premises or to measure
electrical usage by survey or any other method that Landlord, in its reasonable
judgment, deems appropriate.

     11. ASSIGNMENT AND SUBLETTING.

          A. Except in connection with a Permitted Transfer (defined in Section
     11E below), Tenant shall not assign, sublease, transfer or encumber any
     interest in this Lease or allow any third party to use any portion of the
     Premises (collectively or individually, a "Transfer") without the prior
     written consent of Landlord, which consent shall not be unreasonably
     withheld. Without limitation, it is agreed that Landlord's consent shall
     not

                                       9

<PAGE>

     be considered unreasonably withheld if: (1) the proposed transferee's
     financial condition is not adequate for the obligations such transferee is
     assuming in connection with the proposed Transfer, (2) the transferee's
     business or reputation is not suitable for the Building considering the
     business and reputation of the other tenants and the Building's prestige,
     or would result in a violation of another tenant's rights under its lease
     at the Building; (3) the transferee is a governmental agency or occupant of
     the Building; (4) Tenant is in default beyond any applicable notice and
     cure period; (5) any portion of the Building or the Premises would likely
     become subject to additional or different laws as a consequence of the
     proposed Transfer, or (6) Landlord or its leasing agent has received a
     proposal from or made a proposal to the proposed transferee to lease space
     in the Building within six (6) months prior to Tenant's delivery of written
     notice of the proposed Transfer to Landlord. Any attempted Transfer in
     violation of this Section 11, shall, exercisable in Landlord's sole and
     absolute discretion, be void. Consent by Landlord to one or more Transfers
     shall not operate as a waiver of Landlord's rights to approve any
     subsequent Transfers. If Landlord withholds its consent to any Transfer
     contrary to the provisions of this Section 11, Tenant's sole remedy shall
     be to seek an injunction in equity to compel performance by Landlord to
     give its consent and Tenant expressly waives any right to damages in the
     event of such withholding by Landlord of its consent. In no event shall any
     Transfer or Permitted Transfer release or relieve Tenant from any
     obligation under this Lease or any liability hereunder.

          B. If Tenant requests Landlord's consent to a Transfer, Tenant shall
     submit to Landlord (i) financial statements for the proposed transferee,
     (ii) a copy of the proposed assignment or sublease, and (iii) such other
     information as Landlord may reasonably request. After Landlord's receipt of
     the required information and documentation, Landlord shall either. (1)
     consent or reasonably refuse consent to the Transfer in writing; (2) in the
     event of a proposed assignment of this Lease, terminate this Lease
     effective the first to occur of ninety (90) days following written notice
     of such termination or the date that the proposed Transfer would have come
     into effect; and (3) in the event of a proposed subletting, terminate this
     Lease with respect to the portion of the Premises which Tenant proposes to
     sublease effective the first to occur of ninety (90) days following written
     notice of such termination or the date the proposed Transfer would have
     come into effect. Tenant shall pay Landlord a review fee of $1,000.00 for
     Landlord's review of any Permitted Transfer or proposed Transfer. In
     addition, Tenant shall reimburse Landlord for its actual reasonable costs
     and expenses (including, without limitation, reasonable attorney's fees)
     incurred by Landlord in connection with Landlord's review of such proposed
     Transfer or Permitted Transfer.

          C. Tenant shall pay to Landlord fifty percent (50%) of all cash and
     other consideration which Tenant receives as a result of a Transfer that is
     in excess of the rent payable to Landlord hereunder for the portion of the
     Premises and Lease Term covered by the Transfer within ten (10) days
     following receipt thereof by Tenant.

          D. Except as provided below with respect to a Permitted Transfer, if
     Tenant is a corporation, limited liability company, partnership or similar
     entity, and the person, persons or entity which owns or controls a majority
     of the voting interests at the time

                                       10

<PAGE>

     changes for any reason (including but not limited to a merger,
     consolidation or reorganization), such change of ownership or control shall
     constitute a Transfer. The foregoing shall not apply so long as Tenant is
     an entity whose outstanding stock is listed on a nationally recognized
     security exchange, or if at least eighty percent (80%) of its voting stock
     is owned by another entity, the voting stock of which is so listed.

          E. Tenant may assign its entire interest under this Lease or sublet
     the Premises (i) to any entity controlling or controlled by or under common
     control with Tenant or (ii) to any successor to Tenant by purchase, merger,
     consolidation or reorganization (hereinafter, collectively, referred to as
     "PERMITTED TRANSFER") without the consent of Landlord, provided: (1) Tenant
     is not in default under this Lease; (2) if such proposed transferee is a
     successor to Tenant by purchase, said proposed transferee shall acquire all
     or substantially all of the stock or assets of Tenant's business or, if
     such proposed transferee is a successor to Tenant by merger, consolidation
     or reorganization, the continuing or surviving entity shall own all or
     substantially all of the assets of Tenant; (3) with respect to a Permitted
     Transfer to a proposed transferee described in clause (ii), such proposed
     transferee shall have a net worth which is at least equal to the greater of
     Tenant's net worth at the date of this Lease or Tenant's net worth as of
     the day prior to the proposed purchase, merger, consolidation or
     reorganization as evidenced to Landlord's reasonable satisfaction; and (4)
     Tenant shall give Landlord written notice at least thirty (30) days prior
     to the effective date of the proposed purchase, merger, consolidation or
     reorganization.

     12. Mechanic's Liens. Tenant will not permit any mechanic's liens or other
liens to be placed upon the Property. If a lien is attached to the Property,
then, in addition to any other right or remedy of Landlord, Landlord may, but
shall not be obligated to, discharge the same. Any amount paid by Landlord for
any of the aforesaid purposes including, but not limited to, reasonable
attorneys' fees, shall be paid by Tenant to Landlord within thirty (30) days
after demand as Additional Rent. Tenant shall within ten (10) days of receiving
such notice of lien or claim have such lien or claim released of record.
Tenant's failure to comply with the provisions of the foregoing sentence shall
be deemed an Event of Default entitling Landlord to exercise all of its remedies
therefor without the requirement of any additional notice or cure period.

     13. INSURANCE.

          A. Landlord shall, at all times during the Lease Term, procure and
     maintain: (i) policies of insurance covering loss or damage to the Property
     in an amount equal to the full replacement cost of the Building, including
     leasehold improvements in the Premises, which shall provide protection
     against loss by fire and other all-risk casualties including earthquake and
     flood and such other property insurance as may be required by Landlord's
     mortgagee or as otherwise desired by Landlord, and (ii) commercial general
     liability insurance applicable to the Building and the Common Areas,
     providing a minimum limit of $3,000,000.00 per occurrence.

          B. Tenant shall procure and maintain, at its expense, (i) all-risk
     (special form) property insurance in an amount equal to the full
     replacement cost of Tenant's Property

                                       11

<PAGE>

     located in the Premises; (ii) a policy or policies of general liability and
     umbrella or excess liability insurance applying to Tenant's operations and
     use of the Premises, providing a minimum limit of $3,000,000.00 per
     occurrence and in the aggregate, naming Landlord and Landlord's Building
     manager as additional insureds, (iii) automobile liability insurance
     covering owned, non-owned and hired vehicles in an amount not less than a
     combined single limit of $1,000,000.00 per accident, and (iv) workers'
     compensation insurance in accordance with the laws of the State in which
     the Property is located and employer's liability insurance in an amount not
     less than $1,000,000.00 each accident, $1,000,000.00 disease-each employee
     and policy limit, with the insurance policies required under this clause
     (iv) to be endorsed to waive the insurance carriers' right of subrogation.
     Tenant shall maintain the foregoing insurance coverages in effect
     commencing on the earlier to occur of the Commencement Date and the date
     Tenant takes possession of the Premises, and continuing to the end of the
     Lease Term.

          C. The insurance requirements set forth in this Section 13 are
     independent of the waiver, indemnification, and other obligations under
     this Lease and will not be construed or interpreted in any way to restrict,
     limit or modify the waiver, indemnification and other obligations or to in
     any way limit any party's liability under this Lease. In addition to the
     requirements set forth in Sections 13 and 14, the insurance required of
     Tenant under this Lease must be issued by an insurance company with a
     rating of no less than A-VIII in the current Best's Insurance Guide or that
     is otherwise acceptable to Landlord, and admitted to engage in the business
     of insurance in the state in which the Building is located; be primary
     insurance for all claims under it and provide that any insurance carried by
     Landlord, Landlord's Building manager, and Landlord's lenders is strictly
     excess, secondary and noncontributing with any insurance carried by Tenant;
     and provide that insurance may not be cancelled, nonrenewed or the subject
     of change in coverage of available limits of coverage, except upon thirty
     (30) days' prior written notice to Landlord and Landlord's lenders. Tenant
     will deliver to Landlord a legally enforceable certificate of insurance on
     all policies procured by Tenant in compliance with Tenant's obligations
     under this Lease on or before the date Tenant first occupies any portion of
     the Premises, at least ten (10) days before the expiration date of any
     policy and upon the renewal of any policy. Landlord shall have the right to
     approve all deductibles and self-insured retentions under Tenant's
     policies, which approval shall not be unreasonably withheld, conditioned or
     delayed.

          D. Neither Landlord nor Tenant shall be liable (by way of subrogation
     or otherwise) to the other party (or to any insurance company insuring the
     other party) for any loss or damage to any of the property of Landlord or
     Tenant, as the case may be, with respect to their respective property, the
     Building, the Property or the Premises or any addition or improvements
     thereto, or any contents therein, to the extent covered by insurance
     carried or required to be carried by a party hereto even though such loss
     might have been occasioned by the negligence or willful acts or omissions
     of the Landlord or Tenant or their respective employees, agents,
     contractors or invitees. Landlord and Tenant shall give each insurance
     company which issues policies of insurance, with respect to the items
     covered by this waiver, written notice of the terms of this mutual waiver,
     and shall have such insurance policies properly endorsed, if necessary, to
     prevent the invalidation of any of the coverage provided by such insurance
     policies by reason of

                                       12

<PAGE>

     such mutual waiver. For the purpose of the foregoing waiver, the amount of
     any deductible applicable to any loss or damage shall be deemed covered by,
     and recoverable by the insured under the insurance policy to which such
     deductible relates.

     14. INDEMNITY. To the extent not expressly prohibited by law, Landlord and
Tenant each (in either case, the "INDEMNITOR") agree to hold harmless and
indemnify the other and the other's agents, partners, shareholders, members,
officers, directors, beneficiaries and employees (collectively, the
"INDEMNITEES") from any losses, damages, judgments, claims, expenses, costs and
liabilities imposed upon or incurred by or asserted against the Indemnitees,
including without limitation reasonable attorneys' fees and expenses, for claims
by a third party for death or injury to, or damage to property of, third
parties, other than the Indemnitees, that may arise from the negligence or
willful misconduct of Indemnitor or any of Indemnitor's agents, members,
partners or employees. Such third parties shall not be deemed third party
beneficiaries of this Lease. If any action, suit or proceeding is brought
against any of the Indemnitees by reason of the negligence or willful misconduct
of Indemnitor or any of Indemnitor's agents, members, partners or employees,
then Indemnitor will, at Indemnitor's expense and at the option of said
Indemnitees, by counsel reasonably approved by said Indemnitees, resist and
defend such action, suit or proceeding. In addition, to the extent not expressly
prohibited by law, Tenant agrees to hold harmless and indemnify Landlord and
Landlord's Indemnitees from any losses, damages, judgments, claims, expenses,
costs and liabilities imposed upon or incurred by or asserted against Landlord
or Landlord's Indemnitees, including reasonable attorneys' fees and expenses,
for claims by a third party for death or injury to, or damage to property of,
third parties (other than Landlord's Indemnitees) that may arise from any act or
occurrence in the Premises, except to the extent caused by the negligence or
willful misconduct of Landlord or Landlord's Indemnitees. Landlord shall
indemnify, defend and hold Tenant harmless from and against any claims, damages,
costs and expenses arising out of any environmental contamination or clean-up
required for the Building or the land on which the Building is located or
violation of any law, rule or regulation by Landlord, except if due to the acts
of Tenant.

     15. DAMAGES FROM CERTAIN CAUSES. To the extent not expressly prohibited by
law, Landlord shall not be liable to Tenant or Tenant's employees, contractors,
agents, invitees or customers, for any injury to person or damage to property
sustained by Tenant or any such party or any other person claiming through
Tenant resulting from any accident or occurrence in the Premises or any other
portion of the Building caused by the Premises or any other portion of the
Building becoming out of repair or by defect in or failure of equipment, pipes,
or wiring, or by broken glass, or by the backing up of drains, or by gas, water,
steam, electricity, or oil leaking, escaping or flowing into the Premises
(except where due to Landlord's grossly negligent or willful failure to make
repairs required to be made pursuant to other provisions of this Lease, after
the expiration of a reasonable time after written notice to Landlord of the need
for such repairs), nor shall Landlord be liable to Tenant for any loss or damage
that may be occasioned by or through the acts or omissions of other tenants of
the Building or of any other persons whomsoever, including, but not limited to
riot, strike, insurrection, war, court order, requisition, order of any
governmental body or authority, acts of God, fire or theft.

     16. CASUALTY DAMAGE. If the Premises or any part thereof shall be damaged
by fire or

                                       13

<PAGE>

other casualty, Tenant shall give prompt written notice thereof to Landlord. In
case the Building shall be so damaged that substantial alteration or
reconstruction of the Building shall, in Landlord's sole opinion, be required
(whether or not the Premises shall have been damaged by such casualty) or in the
event there is less than one (1) year of the Lease Term remaining or in the
event Landlord's mortgagee should require that the insurance proceeds payable as
a result of a casualty be applied to the payment of the mortgage debt or in the
event of any material uninsured loss to the Building, Landlord may, at its
option, terminate this Lease by notifying Tenant in writing of such termination
within ninety (90) days after the date of such casualty. If Landlord does not
thus elect to terminate this Lease, Landlord shall commence and proceed with
reasonable diligence to restore the Building, and the improvements located
within the Premises to substantially the same condition in which it was
immediately prior to the happening of the casualty. Notwithstanding the
foregoing, Landlord's obligation to restore the Building, and the improvements
located within the Premises shall not require Landlord to expend for such repair
and restoration work more than the insurance proceeds actually received by
Landlord as a result of the casualty. When the repairs described in the
preceding two sentences have been completed by Landlord, Tenant shall complete
the restoration of all furniture, fixtures and equipment which are necessary to
permit Tenant's reoccupancy of the Premises. Landlord shall not be liable for
any inconvenience or annoyance to Tenant or injury to the business of Tenant
resulting in any way from such damage or the repair thereof, except that Rent
shall be abated from the date of the damage or destruction for any portion of
the Premises that is unusable by Tenant, which abatement shall be in the same
proportion that the Rentable Area of the Premises which is unusable by Tenant
bears to the total Rentable Area of the Premises; provided that Tenant shall not
be entitled to any abatement of Rent if the damage or destruction within the
Premises is restored within five (5) Business Days after Landlord's receipt of
written notice from Tenant of the occurrence of the damage or destruction.

     17. CONDEMNATION. If the whole or any substantial part of the Premises or
if the Building or any portion thereof which would leave the remainder of the
Building unsuitable for use comparable to its use on the Commencement Date, or
if the land on which the Building is located or any material portion thereof,
shall be taken or condemned for any public or quasi-public use under
governmental law, ordinance or regulation, or by right of eminent domain, or by
private purchase in lieu thereof, then Landlord may, at its option, terminate
this Lease and Rent shall be abated during the unexpired portion of this Lease,
effective when the physical taking of said Premises or said portion of the
Building or land shall occur. If this Lease is not terminated, the rent for any
portion of the Premises so taken or condemned shall be abated during the
unexpired Lease Term effective when the physical taking of said portion of the
Premises shall occur. All compensation awarded for any taking or condemnation,
or sale proceeds in lieu thereof, shall be the property of Landlord, and Tenant
shall have no claim thereto, the same being hereby expressly waived by Tenant,
except for any portions of such award or proceeds which are specifically
allocated by the condemning or purchasing party for the taking of or damage to
trade fixtures of Tenant and moving costs, which Tenant specifically reserves to
itself.

     18. EVENTS OF DEFAULT. The following events shall be deemed to be "EVENTS
OF DEFAULT" under this Lease: (i) Tenant fails to pay any Rent when due;
provided that the first (1st) such failure during any consecutive twelve (12)
month period during the Term shall not be

                                       14

<PAGE>

an Event of Default if Tenant pays the amount due within five (5) days after
Tenant's receipt of written notice from Landlord that such payment was not made
when due, (ii) Tenant fails to perform any other provision of this Lease not
described in this Section 18, and such failure is not cured within thirty (30)
days (or immediately if the failure involves a hazardous condition) after notice
from Landlord, however, other than with respect to a hazardous condition, if
Tenant's failure to comply cannot reasonably be cured within thirty (30) days,
Tenant shall be allowed additional time (not to exceed thirty (30) additional
days) as is reasonably necessary to cure the failure so long as Tenant begins
the cure within thirty (30) days and diligently pursues the cure to completion;
(iii) Tenant fails to observe or perform any of the covenants with respect to
(a) assignment and subletting as set forth in Section 11, and such failure is
not cured within ten (10) days after notice from Landlord, (b) mechanic's liens
as set forth in Section 12, and such failure is not cured within time periods
provided therein, (c) insurance as set forth in Section 13, and such failure is
not cured within time periods provided therein, or (d) delivering subordination
agreements or estoppel certificates as set forth in Section 24, and such failure
is not cured within time periods provided therein; (iv) the leasehold interest
of Tenant is levied upon or attached under process of law; (v) Tenant or any
guarantor of this Lease dies or dissolves; (vi) Tenant abandons or vacates the
Premises; or (vii) any voluntary or involuntary proceedings are filed by or
against Tenant or any guarantor of this Lease under any bankruptcy, insolvency
or similar laws and, in the case of any involuntary proceedings, are not
dismissed within sixty (60) days after filing.

     19. Remedies.

          A. Upon the occurrence of any Event of Default, Landlord shall have
     the following rights and remedies, in addition to those allowed by law or
     equity, any one or more of which may be exercised without further notice to
     or demand upon Tenant and which may be pursued successively or cumulatively
     as Landlord may elect:

          (1)  Landlord may re-enter the Premises and attempt to cure any
               default of Tenant, in which event Tenant all, upon demand,
               reimburse Landlord as Additional Rent for all reasonable costs
               and expenses which Landlord incurs to cure such default;

          (2)  Landlord may terminate this Lease by giving to Tenant notice of
               Landlord's election to do so, in which event the Lease Term shall
               end, and all right, title and interest of Tenant hereunder shall
               expire, on the date stated in such notice;

          (3)  Landlord may terminate the right of Tenant to possession of the
               Premises without terminating this Lease by giving notice to
               Tenant that Tenant's right to possession shall end on the date
               stated in such notice, whereupon the right of Tenant to
               possession of the Premises or any part thereof shall cease on the
               date stated in such notice; and

          (4)  Landlord may enforce the provisions of this Lease by a suit or
               suits in equity or at law for the specific performance of any
               covenant or agreement

                                       15

<PAGE>

               contained herein, or for the enforcement of any other appropriate
               legal or equitable remedy, including recovery of all moneys due
               or to become due from Tenant under any of the provisions of this
               Lease.

     Landlord shall not be required to serve Tenant with any notices or demands
     as a prerequisite to its exercise of any of its rights or remedies under
     this Lease, other than those notices and demands specifically required
     under this Lease. TENANT WAIVES ANY RIGHT TO TRIAL BY JURY IN ANY LAWSUIT
     BROUGHT BY LANDLORD TO RECOVER POSSESSION OF THE PREMISES FOLLOWING
     LANDLORD'S TERMINATION OF THIS LEASE OR THE RIGHT OF TENANT TO POSSESSION
     OF THE PREMISES PURSUANT TO THE TERMS OF THIS LEASE AND ON ANY CLAIM FOR
     DELINQUENT RENT WHICH LANDLORD MAY JOIN IN ITS LAWSUIT TO RECOVER
     POSSESSION.

          B. If Landlord exercises either of the remedies provided in Sections
     19A(2) or 19A(3), Tenant shall surrender possession and vacate the Premises
     and immediately deliver possession thereof to Landlord, and Landlord may
     re-enter and take complete and peaceful possession of the Premises, with
     process of law, and Landlord may remove all occupants and property
     therefrom, using such force as may be necessary to the extent allowed by
     law, without being deemed guilty in any manner of trespass, eviction or
     forcible entry and detainer and without relinquishing Landlord's right to
     Rent or any other right given to Landlord hereunder or by operation of law.

          C. If Landlord terminates the right of Tenant to possession of the
     Premises without terminating this Lease, Landlord shall have the right to
     immediate recovery of all amounts then due hereunder. Such termination of
     possession shall not release Tenant, in whole or in part, from Tenant's
     obligation to pay Rent hereunder for the full Lease Term, and Landlord
     shall have the right, from time to time, to recover from Tenant, and Tenant
     shall remain liable for, all Rent accruing as it becomes due under this
     Lease during the period from the date of such notice of termination of
     possession to the stated end of the Lease Term. In any such case, Landlord
     shall make reasonable efforts, in accordance with Section 19E hereof, to
     relet the Premises. In attempting to relet the Premises, Landlord may make
     repairs, alterations and additions in or to the Premises and redecorate the
     same to the extent reasonably deemed by Landlord necessary or desirable,
     and Tenant upon demand shall pay the reasonable cost of all of the
     foregoing together with Landlord's reasonable expenses of reletting. The
     rents from any such reletting shall be applied first to the payment of the
     expenses of reentry, redecoration, repair and alterations and the expenses
     of reletting (including reasonable attorneys' fees and brokers' fees and
     commissions) and second to the payment of Rent herein provided to be paid
     by Tenant. Any excess or residue shall operate only as an offsetting credit
     against the amount of Rent due and owing as the same thereafter becomes due
     and payable hereunder.

          D. If this Lease is terminated by Landlord, Landlord shall be entitled
     to recover from Tenant all Rent accrued and unpaid for the period up to and
     including such termination date, as well as all other additional sums
     payable by Tenant, or for which Tenant is liable or for which Tenant has
     agreed to indemnify Landlord, which may be then

                                       16

<PAGE>

     owing and unpaid, and all reasonable costs and expenses, including court
     costs and reasonable attorneys' fees incurred by Landlord in the
     enforcement of its rights and remedies hereunder.

          E. Landlord shall use commercially reasonable efforts to mitigate any
     damages resulting from an Event of Default by Tenant under this Lease.
     Landlord's obligation to mitigate damages after an Event of Default by
     Tenant under this Lease shall be satisfied in full if Landlord undertakes
     to lease the Premises to another tenant (a "SUBSTITUTE TENANT") in
     accordance with the following criteria: (1) Landlord shall have no
     obligation to solicit or entertain negotiations with any other prospective
     tenants for the Premises until Landlord obtains full and complete
     possession of the Premises including, without limitation, the final and
     unappealable legal right to relet the Premises free of any claim of Tenant;
     (2) Landlord shall not be obligated to lease or show the Premises, on a
     priority basis, or offer the Premises to a prospective tenant when other
     premises in the Building suitable for that prospective tenant's use are (or
     soon will be) available; (3) Landlord shall not be obligated to lease the
     Premises to a Substitute Tenant for a rent less than the current fair
     market rent then prevailing for similar uses in comparable buildings in the
     same market area as the Building, nor shall Landlord be obligated to enter
     into a new lease under other terms and conditions that are unacceptable to
     Landlord under Landlord's then current leasing policies for comparable
     space in the Building; (4) Landlord shall not be obligated to enter into a
     lease with a Substitute Tenant whose use would: (i) violate any
     restriction, covenant, or requirement contained in the lease of another
     tenant of the Building; (ii) adversely affect the reputation of the
     Building; or (iii) be incompatible with the operation of the Building; and
     (5) Landlord shall not be obligated to enter into a lease with any proposed
     Substitute Tenant which does not have, in Landlord's reasonable opinion,
     sufficient financial resources to operate the Premises in a first class
     manner and to fulfill all of the obligations in connection with the lease
     thereof as and when the same become due.

          F. The receipt by Landlord of less than the full Rent due shall not be
     construed to be other than a payment on account of Rent then due, nor shall
     any statement on Tenant's check or any letter accompanying Tenant's check
     be deemed an accord and satisfaction, and Landlord may accept such payment
     without prejudice to Landlord's right to recover the balance of the Rent
     due or to pursue any other remedies provided in this Lease. The acceptance
     by Landlord of Rent hereunder shall not be construed to be a waiver of any
     breach by Tenant of any term, covenant or condition of this Lease. No act
     or omission by Landlord or its employees or agents during the Lease Term
     shall be deemed an acceptance of a surrender of the Premises, and no
     agreement to accept such a surrender shall be valid unless in writing and
     signed by Landlord.

          G. To the extent allowed by law, all installments of Rent not paid
     when due shall bear interest at the Default Rate from the date due until
     paid. In the event of any litigation between Tenant and Landlord to enforce
     or interpret any provision of this Lease or to enforce any right of either
     party hereto, the unsuccessful party to such litigation shall pay to the
     successful party all costs and expenses, including reasonable attorney's
     fees, incurred therein.

                                       17

<PAGE>

     20. NO WAIVER. Failure of either party to declare any default immediately
upon its occurrence, or delay in taking any action in connection with an event
of default, shall not constitute a waiver of such default, nor shall it
constitute an estoppel against the non-defaulting party, but the non-defaulting
party shall have the right to declare the default at any time and take such
action as is lawful or authorized under this Lease. Failure by non-defaulting
party to enforce its rights with respect to any one default shall not constitute
a waiver of its rights with respect to any subsequent default.

     21. PEACEFUL ENJOYMENT. Tenant shall, and may peacefully have, hold, and
enjoy the Premises, subject to the other terms hereof, provided that Tenant pays
the Rent and other sums herein recited to be paid by Tenant and timely performs
all of Tenant's covenants and agreements herein contained.

     22. SUBSTITUTION. Landlord at its sole discretion shall be entitled to
cause Tenant to relocate from the Premises to a comparably-sized space, of
comparable design and tenant improvements (the "RELOCATION SPACE") within the
Building or adjacent buildings within the same Property at any time upon not
less than ninety (90) days' prior written notice to Tenant. The reasonable costs
actually incurred in connection with the buildout of the Relocation Space and
the physical relocation of the Tenant to the Relocation Space shall be at the
expense of Landlord. Such a relocation shall not terminate or otherwise affect
or modify this Lease except that from and after the date of such relocation,
"Premises" shall refer to the Relocation Space into which Tenant has been moved,
rather than the original Premises as herein defined and the Base Rent shall be
adjusted so that immediately following such relocation the Base Rent for the
Relocation Space on a per square foot of rentable area basis shall be the same
as the Base Rent immediately prior to such relocation for the original Premises
on a per square foot of rentable area basis. Tenant's Pro Rata Share also be
adjusted in accordance with the formula set forth in this Lease.

     Notwithstanding anything to the contrary contained in this Section 22, in
the event that Landlord elects to relocate Tenant as provided herein, then
Tenant shall have the right to terminate this Lease as of the date of
substitution described in Landlord's notice, by notice received by Landlord
within ten (10) days after Tenant's receipt of such notice; provided however,
Landlord shall have the right to withdraw such right to substitute Premises by
notice to Tenant within ten (10) days after receipt of Tenant's notice to
terminate this Lease, in which case this Lease shall remain in full force and
effect without modification.

     23. HOLDING OVER. If Tenant continues to occupy the Premises after the
expiration or other termination of this Lease or the termination of Tenant's
right of possession, such occupancy shall be that of a tenancy at sufferance.
Tenant shall, throughout the entire holdover period, be subject to all the terms
and provisions of this Lease and shall pay for its use and occupancy an amount
(on a per month basis without reduction for any partial months during any such
holdover) equal to one hundred fifty percent (150%) of the Base Rent and
Additional Rent due under this Lease for the last full month of the term hereof
during the first thirty (30) days of such holdover, and two hundred percent
(200%) of such Base Rent and Additional Rent thereafter during such holdover. No
holding over by Tenant or payments of money by Tenant to

                                       18

<PAGE>

Landlord after the expiration of the Lease Term shall be construed to extend the
Lease Term or prevent Landlord from recovery of immediate possession of the
Premises by summary proceedings or otherwise Tenant shall also be liable to
Landlord for all direct and consequential damages which Landlord may suffer by
reason of any holding over by Tenant.

     24. SUBORDINATION TO MORTGAGE: ESTOPPEL CERTIFICATE. Tenant accepts this
Lease subject and subordinate to any ground lease, mortgage, deed of trust or
other lien presently existing or hereafter arising upon the Premises, or upon
the Building or the Property and to any renewals, modifications, refinancings
and extensions thereof, but Tenant agrees that any such mortgagee shall have the
right at any time to subordinate such mortgage, deed of trust or other lien to
this Lease on such terms and subject to such conditions as such mortgagee may
deem appropriate in its discretion. The provisions of the foregoing sentence
shall be self-operative and no further instrument of subordination shall be
required. However, Landlord is hereby irrevocably vested with full power and
authority to subordinate this Lease to any mortgage, deed of trust or other lien
now existing or hereafter placed upon the Premises, or the Building or the
Property and Tenant agrees within ten (10) days after written demand to execute
such further instruments subordinating this Lease or attorning to the holder of
any such liens as Landlord may request. If Tenant fails to execute any
subordination or other agreement required by this Section promptly as requested,
Tenant hereby irrevocably constitutes Landlord as its attorney-in-fact to
execute such instrument in Tenant's name, place and stead, it being agreed that
such power is coupled with an interest in Landlord and is accordingly
irrevocable. In addition, if Tenant fails to deliver any subordination or other
agreement required by this Section within three (3) business days after receipt
of a second request from Landlord, then Tenant shall pay Landlord, as additional
rent, a $100 per day penalty from the end of the three business-day period until
the date such documents are signed and received by Landlord. Tenant agrees that
it shall from time-to-time furnish within ten (10) days after so requested by
Landlord, a certificate signed by Tenant certifying as to such matters as may be
reasonably requested by Landlord. Any such certificate may be relied upon by any
ground lessor, prospective purchaser, secured party, mortgagee or any
beneficiary under any mortgage, deed of trust on the Building or the Property or
any part thereof or interest of Landlord therein.

     25. NOTICE. Any. notice required or permitted to be given under this Lease
or by law shall be deemed to have been given if it is written and delivered in
person or mailed by Registered or Certified mail, postage prepaid, or sent by a
nationally recognized overnight delivery service to the party who is to receive
such notice at the address specified in Section 1 of this Lease (and, if no
address is listed for Tenant, notices to Tenant shall be delivered to the
Premises). When so mailed, the notice shall be deemed to have been given two (2)
Business Days after the date it was mailed. When sent by overnight delivery
service, the notice shall be deemed to have been given on the next Business Day
after deposit with such overnight delivery service. The address specified in
Section 1 of this Lease may be changed from time to time by giving written
notice thereof to the other party.

     26. SURRENDER OF PREMISES. Upon the termination of the Lease Term, or upon
any termination of Tenant's right to possession of the Premises, Tenant will at
once surrender possession of the Premises to Landlord in good condition and
repair, ordinary wear and tear excepted. Tenant shall surrender to Landlord all
keys to the Premises and make known to

                                       19

<PAGE>

Landlord the combination of all combination locks which Tenant is required to
leave on the Premises.

     27. RIGHTS RESERVED TO LANDLORD. Landlord reserves the following rights,
exercisable without notice, except as provided herein, and without liability to
Tenant for damage or injury to property, person or business and without
affecting an eviction or disturbance of Tenant's use or possession or giving
rise to any claim for setoff or abatement of rent or affecting any of Tenant's
obligations under this Lease: (1) upon thirty (30) days' prior notice to change
the name or street address of the Building; (2) to install and maintain signs on
the exterior and interior of the Building; (3) to designate and approve window
coverings to present a uniform exterior appearance; (4) to retain at all times
and to use in appropriate instances, pass keys to all locks within and to the
Premises; (5) to approve the weight, size, or location of heavy equipment, or
articles within the Premises; (6) to change the arrangement and location of
entrances of passageways, doors and doorways, corridors, elevators, stairs,
toilets and public parts of the Building or Property, and to construct any
desired improvements on the Property; (7) to regulate access to telephone,
electrical and other utility closets in the Building and to require use of
designated contractors for any work involving access to the same; (8) if Tenant
has vacated the Premises during the last six (6) months of the Lease Term, to
perform additions, alterations and improvements to the Premises in connection
with a reletting or anticipated reletting thereof without being responsible or
liable for the value or preservation of any then existing improvements to the
Premises and without effectuating a surrender or entitling Tenant to any
abatement of Rent; (9) to grant to anyone the exclusive right to conduct any
business or undertaking in the Building provided Landlord's exercise of its
rights under this clause (9), shall not be deemed to prohibit Tenant from the
operation of its business in the Premises; (10) to enter the Premises to inspect
the same or to show the Premises to prospective purchasers, mortgagees, tenants
(during the last twelve months of the Lease Term) or insurers, or to clean or
make repairs, alterations or additions thereto, provided that, except for any
entry in an emergency situation or to provide normal cleaning and janitorial
service, Landlord shall provide Tenant with reasonable prior notice of any entry
into the Premises; and (11) to temporarily close the Premises or the Building to
perform repairs, alterations or additions in the Premises or the Building. In
exercising its rights under this Section 27, Landlord shall make commercially
reasonable efforts to avoid unreasonably interfering with Tenant's business
operations in the Premises, and if any temporary closing continues for more than
one business day, a pro rata reduction in Rent for the applicable month shall
occur.

     28. MISCELLANEOUS.

          A. If any term or provision of this Lease, or the application thereof,
     shall, to any extent, be invalid or unenforceable, the remainder of this
     Lease, or the application of such term or provision, shall not be affected
     thereby, and each term and provision of this Lease shall be valid and
     enforced to the fullest extent permitted by law.

          B. Tenant agrees not to record this Lease or any short form or
     memorandum hereof.

          C. This Lease and the rights and obligations of the parties hereto
     shall be

                                       20

<PAGE>

     interpreted, construed, and enforced in accordance with the laws of the
     state in which the Building is located.

          D. The term "FORCE MAJEURE" shall mean strikes, riots, acts of God,
     shortages of labor or materials, war, acts of terrorism, governmental laws,
     regulations or restrictions, or any other cause whatsoever beyond the
     control of Landlord or Tenant, as the case may be. Whenever a period of
     time is herein prescribed for the taking of any action by Landlord or
     Tenant (other than the payment of Rent and all other such sums of money as
     shall become due hereunder), such party shall not be liable or responsible
     for, there shall be excluded from the computation of such period of time,
     any delays due to events of Force Majeure.

          E. Except as expressly otherwise herein provided, with respect to all
     required acts of Tenant and Landlord, time is of the essence of this Lease.

          F. Landlord shall have the right to transfer and assign, in whole or
     in part, all of its rights and obligations hereunder and in the Building
     and Property referred to herein, and in such event and upon such transfer
     Landlord shall be released from any further obligations hereunder, and
     Tenant agrees to look solely to such successor in interest of Landlord for
     the performance of such obligations.

          G. Tenant hereby represents to Landlord that it has dealt directly
     with and only with the Broker as a broker in connection with this Lease.
     Landlord and Tenant hereby indemnify and hold each other harmless against
     any loss, claim, expense or liability with respect to any commissions or
     brokerage fees claimed by any broker or finder other than the Broker on
     account of the execution and/or renewal of this Lease due to any action of
     the indemnifying party.

          H. Intentionally omitted.

          I. Tenant acknowledges that the financial capability of Tenant to
     perform its obligations hereunder is material to Landlord and that Landlord
     would not enter into this Lease but for its belief, based on its review of
     Tenant's financial statements, that Tenant is capable of performing such
     financial obligations. Tenant hereby represents, warrants and certifies to
     Landlord that its financial statements previously furnished to Landlord
     were at the time given true and correct in all material respects and that
     there have been no material subsequent changes thereto as of the date of
     this Lease. In the event of a proposed sale or other transfer, financing or
     refinancing by Landlord of the Building, where the proposed lender or
     purchaser requests tenant financial statements, within ten (10) days after
     Landlord's request, Tenant shall deliver to Landlord the most current
     year-end financial statements of Tenant and any guarantor of this Lease,
     subject to any reasonable confidentiality agreement.

          J. Notwithstanding anything to the contrary contained in this Lease,
     the expiration of the Lease Term, whether by lapse of time or otherwise,
     shall not relieve Tenant from Tenant's obligations accruing prior to the
     expiration of the Lease Term, and such obligations shall survive any such
     expiration or other termination of the Lease Term.

                                       21

<PAGE>

          K. Landlord and Tenant understand, agree and acknowledge that (i) this
     Lease has been freely negotiated by both parties; and (ii) in any
     controversy, dispute or contest over the meaning, interpretation, validity,
     or enforceability of this Lease or any of its terms or conditions, there
     shall be no inference, presumption, or conclusion drawn whatsoever against
     either party by virtue of that party having drafted this Lease or any
     portion thereof.

          L. The headings and titles to the paragraphs of this Lease are for
     convenience only and shall have no affect upon the construction or
     interpretation of any part hereof. The term "including" shall be deemed to
     mean "including without limitation".

     29. NO OFFER. Landlord has delivered a copy of this Lease to Tenant for
Tenant's review only, and the delivery hereof does not constitute an offer to
Tenant or an option. This Lease shall not be effective until an original of this
Lease executed by both Landlord and Tenant and an original Guaranty, if
applicable, executed by each Guarantor is delivered to and accepted by Landlord,
and this Lease has been approved by Landlord's mortgagee, if required.

     30. ENTIRE AGREEMENT. This Lease, including the Exhibits attached hereto,
constitutes the entire agreement between the parties hereto with respect to the
subject matter of this Lease and supersedes all prior agreements and
understandings between the parties related to the Premises, including all lease
proposals, letters of intent and similar documents. Tenant expressly
acknowledges and agrees that Landlord has not made and is not making, and
Tenant, in executing and delivering this Lease, is not relying upon, any
warranties, representations, promises or statements, except to the extent that
the same are expressly set forth in this Lease. This Lease may be modified only
be a written agreement signed by Landlord and Tenant. Landlord and Tenant
expressly agree that there are and shall be no implied warranties of
merchantability, habitability, suitability, fitness for a particular purpose or
of any other kind arising out of this Lease, all of which are hereby waived by
Tenant, and that there are no warranties which extend beyond those expressly set
forth in this Lease.

     31. LIMITATION OF LIABILITY. Any liability of Landlord under this Lease
shall be limited solely to its interest in the Property, and in no event shall
any personal liability be asserted against Landlord, its members, or their
respective members, partners, shareholders, officers, directors, agents or
employees, in connection with this Lease nor shall any recourse be had to any
other property or assets of Landlord, its members, or their respective members,
partners, shareholders, officers, directors, agents or employees (except if due
to such individuals gross negligence or intentional misconduct) as a result of
any liability for damage or breach or non-performance by Landlord. In no event
shall Landlord be liable for consequential or punitive damages as a result of a
breach or default under or otherwise in connection with this Lease.

                            [SIGNATURE PAGE FOLLOWS]

                                       22

<PAGE>

     IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the
day and year first above written.

WITNESS/ATTEST                          LANDLORD:

                                        TRANSWESTERN GREAT LAKES, L.P.,
By: /s/ William Hemingway               a Delaware limited partnership
    ---------------------------------
Name: William Hemingway                 By: TRANSWESTERN GREAT LAKES GP, L.L.C.,
Title: Executive VP                         a Maryland limited liability
                                            company, its general partner

By: /s/                                 By: TRANSWESTERN INVESTMENT COMPANY,
    ---------------------------------       L.L.C., its authorized agent
Name:
      -------------------------------
Title:                                  By: /s/ Scott A. Tausk
       ------------------------------       ------------------------------------
                                        Name: Scott A. Tausk
                                        Title: Managing Director

WITNESS/ATTEST                          TENANT:

                                        QUATRX PHARMACEUTICALS COMPANY, a ______
By: /s/ Gary Onn
    ---------------------------------
Name: Gary Onn                          By: /s/ Robert L. Zerbe
Title: CFO                                  ------------------------------------
                                        Name: Robert L. Zerbe
                                        Title: CEO

By: /s/
    ---------------------------------
Name:
      -------------------------------
Title:
       ------------------------------

                                       23

<PAGE>

                                  EXHIBIT A-1

                                  (FLOOR PLAN)

                                      A-1

<PAGE>

                                    EXHIBIT B

                              RULES AND REGULATIONS

The following rules and regulations shall apply, where applicable, to the
Premises, the Building, the parking areas associated therewith (if any), the
Property and the appurtenances thereto:

     1. Sidewalks, entrances, passageways, courts, corridors, vestibules, halls,
elevators and stairways in and about the Building shall not be obstructed nor
shall objects be placed against glass partitions, doors or windows which would
be unsightly from the Building's corridors or from the exterior of the Building.

     2. Plumbing, fixtures and appliances shall be used for only the purpose for
which they were designed and no foreign substance of any kind whatsoever shall
be thrown or placed therein. Damage resulting to any such fixtures or appliances
from misuse by Tenant or its agents, employees or invitees, shall be paid for by
Tenant and Landlord shall not in any case be responsible therefor.

     3. Any sign, lettering, picture, notice or advertisement installed within
the Premises which is visible from the public corridors within the Building
shall be installed in such manner, and be of such character and style, as
Landlord shall approve, in writing in its reasonable discretion. No sign,
lettering, picture, notice or advertisement shall be placed on any outside
window or door or in a position to be visible from outside the Building. No
nails, hooks or screws (except for customary artwork or wall hangings) shall be
driven or inserted into any part of the Premises or Building except by Building
maintenance personnel, nor shall any part of the Building be defaced or damaged
by Tenant.

     4. Tenant shall not place any additional lock or locks on any door in the
Premises or Building without Landlord's prior written consent. A reasonable
number of keys to the locks on the doors in the Premises shall be furnished by
Landlord to Tenant at the cost of Tenant, and Tenant shall not have any
duplicate keys made. All keys and passes shall be returned to Landlord at the
expiration or earlier termination of the Lease.

     5. Tenant shall refer all contractors, contractors' representatives and
installation technicians to Landlord for Landlord's supervision, approval and
control before the performance of any contractual services. This provision shall
apply to all work performed in the Building including, but not limited to
installation of telephones, telegraph equipment, electrical devices and
attachments, doors, entranceways, and any and all installations of every nature
affecting floors, walls, woodwork, window trim, ceilings, equipment and any
other physical portion of the Building. Tenant shall not waste electricity,
water or air conditioning. All controls shall be adjusted only by Building
personnel.

     6. Movement in or out of the Building of furniture or office equipment, or
dispatch or receipt by Tenant of any merchandise or materials which require the
use of elevators, stairways, lobby areas, or loading dock areas, shall be
restricted to hours designated by Landlord. Tenant must seek Landlord's prior
approval by providing in writing a detailed listing of such activity. If

                                      B-1

<PAGE>

approved by Landlord, such activity shall be under the supervision of Landlord
and performed in the manner stated by Landlord. Landlord may not unreasonably
prohibit any article, equipment or any other item from being brought into the
Building. Tenant is to assume all risk for damage to articles moved by or at the
direction of Tenant and injury to persons resulting from such activity. If any
equipment, property and/or personnel of Landlord or of any other tenant is
damaged or injured as a result of or in connection with such activity by or at
the direction of Tenant, Tenant shall be solely liable for any and all damage or
loss resulting therefrom.

     7. All corridor doors, when not in use, shall remain closed. Tenant shall
cause all doors to the Premises to be closed and securely locked before leaving
the Building at the end of the day.

     8. Tenant shall keep all electrical and mechanical apparatus owned by
Tenant free of vibration, noise and airwaves which may be transmitted beyond the
Premises.

     9. Canvassing, soliciting and peddling in or about the Building or Property
is prohibited. Tenant shall cooperate and use its best efforts to prevent the
same.

     10. Tenant shall not use the Premises in any manner which would overload
the standard heating, ventilating or air conditioning systems of the Building.

     11. Tenant shall not utilize any equipment or apparatus in such manner as
to create any magnetic fields or waves which adversely affect or interfere with
the operation of any systems or equipment in the Building or Property.

     12. Bicycles and other vehicles are not permitted inside or on the walkways
outside the Building, except in those areas specifically designated by Landlord
for such purposes.

     13. Tenant shall not operate or permit to be operated on the Premises any
coin or token operated vending machine or similar device (including, without
limitation, telephones, lockers, toilets, scales, amusements devices and
machines for sale of beverages, foods, candy, cigarettes or other goods), except
for those vending machines or similar devices which are for the sole and
exclusive use of Tenant's employees, and then only if such operation does not
violate the lease of any other tenant in the Building.

     14. Tenant shall utilize the termite and pest extermination service
designated by Landlord to control termites and pests in the Premises. Except as
included in Basic Costs, Tenant shall bear the cost and expense of such
extermination services.

     15. Tenant shall not open or permit to be opened any window in the
Premises. This provision shall not be construed as limiting access of Tenant to
any balcony adjoining the Premises.

     16. To the extent permitted by law, Tenant shall not permit picketing or
other union activity involving its employees or agents in the Building or on the
Property, except in those locations and subject to time and other constraints as
to which Landlord may give its prior

                                      B-2

<PAGE>

written consent, which consent may be withheld in Landlord' sole discretion.

     17. Tenant shall comply with all applicable laws, ordinances, governmental
orders or regulations and applicable orders or directions from any public office
or body having jurisdiction, with respect to the Premises, the Building, the
Property and their respective use or occupancy thereof. Tenant shall not make or
permit any use of the Premises, the Building or the Property, respectively,
which is directly or indirectly forbidden by law, ordinance, governmental
regulation or order, or direction of applicable public authority, or which may
be dangerous to person or property.

     18. Tenant shall not use or occupy the Premises in any manner or for any
purpose which would injure the reputation or impair the present or future value
of the Premises, the Building or the Property; without limiting the foregoing,
Tenant shall not use or permit the Premises or any portion thereof to be used
for lodging, sleeping or for any illegal purpose.

     19. All deliveries to or from the Premises shall be made only at times, in
the areas and through the entrances and exits designated for such purposes by
Landlord. Tenant shall not permit the process of receiving deliveries to or from
the Premises outside of said areas or in a manner which may interfere with the
use by any other tenant of its premises or any common areas, any pedestrian use
of such area, or any use which is inconsistent with good business practice.

     20. Tenant shall carry out Tenant's permitted repair, maintenance,
alterations, and improvements in the Premises only during times agreed to in
advance by Landlord and in a manner which will not interfere with the rights of
other tenants in the Building.

     21. Landlord may from time to time adopt appropriate systems and procedures
for the security or safety of the Building, its occupants, entry and use, or its
contents. Tenant, Tenant's agents, employees, contractors, guests and invitees
shall comply with Landlord's reasonable requirements thereto.

     22. Landlord shall have the right to prohibit the use of the name of the
Building or any other publicity by Tenant that in Landlord's opinion may tend to
impair the reputation of the Building or its desirability for Landlord or its
other tenants. Upon written notice from Landlord, Tenant will refrain from
and/or discontinue such publicity immediately.

     23. Neither Tenant nor any of its employees, agents, contractors, invitees
or customers shall smoke in any area designated by Landlord (whether through the
posting of a "no smoking" sign or otherwise) as a "no smoking" area. In no event
shall Tenant or any of its employees, agents, contractors, invitees or customers
smoke in the hallways or bathrooms of the Building or at the entrances to the
Building. Landlord reserves the right to designate, from time to time,
additional areas of the Building and the Property as "no smoking" areas and to
designate the entire Building and the Property as a "no smoking" area.

                               [END OF EXHIBIT B]

                                      B-3

<PAGE>

                                    EXHIBIT C

                             PAYMENT OF BASIC COSTS

     A. During each calendar year, or portion thereof, falling within the Lease
Term, Tenant shall pay to Landlord as Additional Rent hereunder Tenant's Pro
Rata Share of the amount by which (a) Basic Costs (as defined below) for the
applicable calendar year exceeds Basic Costs for the Base Year, and (b) Taxes
(as defined below) for the applicable calendar year exceeds Taxes for the Base
Year. Prior to the Commencement Date, or as soon as practical thereafter, and
prior to January 1 of each calendar year during the Lease Term, or as soon as
practical thereafter, Landlord shall make a good faith estimate of Basic Costs
and Taxes for the applicable full or partial calendar year and Tenant's Pro Rata
Shares thereof. On or before the first day of each month during such calendar
year, Tenant shall pay Landlord, as Additional Rent, a monthly installment equal
to one-twelfth of Tenant's Pro Rata Share of (1) Landlord's estimate of the
amount by which Basic Costs for such calendar year will exceed Basic Costs for
the Base Year, and (2) Landlord's estimate of the amount by which Taxes for such
calendar year will exceed Taxes for the Base Year. Landlord shall have the right
from time to time during any such calendar year to reasonably revise the
estimate of Basic Costs and Taxes for such year and provide Tenant with a
revised statements therefor (provided, however, Landlord agrees that Landlord
shall not issue a revised statement more than twice in any calendar year for
Basic Costs and twice in any calendar year for Taxes), and thereafter the amount
Tenant shall pay each month shall be based upon such revised estimate. If
Landlord does not provide Tenant with an estimate of the Basic Costs and/or
Taxes by January 1 of any calendar year, Tenant shall continue to pay a monthly
installment based on the previous year's estimate until such time as Landlord
provides Tenant with an estimate of Basic Costs and/or Taxes for the current
year. Upon receipt of such current year's estimate, an adjustment shall be made
for any month during the current year with respect to which Tenant paid monthly
installments of Additional Rent based on the previous year's estimate. Tenant
shall pay Landlord for any underpayment within thirty (30) days after Landlord's
written demand. Any overpayment of Additional Rent shall, at Landlord's option,
be refunded to Tenant or credited against the installments of Additional Rent
next coming due under the Lease. Any amount paid by Tenant based on any estimate
shall be subject to adjustment pursuant to Paragraph B below when actual Basic
Costs or actual Taxes, as applicable, are determined.

     B. As soon as is practical following the end of each calendar year during
the Lease Term, Landlord shall furnish to Tenant a statement of Landlord's
actual Basic Costs. and Taxes for the previous calendar year. If for any
calendar year the Additional Rent collected for the prior year, as a result of
Landlord's estimate of Basic Costs or Taxes, is in excess of Tenant's Pro Rata
Share of the amount by which Basic Costs or Taxes, as applicable, for such prior
year exceeds Basic Costs or Taxes for the Base Year, then Landlord shall refund
to Tenant any overpayment (or at Landlord's option apply such amount against
Additional Rent due or to become due hereunder). Likewise, Tenant shall pay to
Landlord, on demand, any underpayment with respect to the prior year whether or
not the Lease has terminated prior to receipt by Tenant of a statement for such
underpayment, it being understood that this clause shall survive the expiration
of the Lease.

                                      C-1

<PAGE>

     C. "Basic Costs" shall mean all reasonable direct and indirect costs,
expenses paid and disbursements of every kind (subject to the limitations set
forth below), which Landlord incurs, pays or becomes obligated to pay in each
calendar year in connection with operating, maintaining, repairing, owning and
managing the Building and the Property. Basic Costs shall include, without
limitation, insurance premiums and deductibles, and the amortized cost of
capital improvements made to the common areas of the Building or on the Property
which are (i) primarily for the purpose of reducing operating expense costs or
otherwise improving the operating efficiency of the Property or Building; or
(ii) required to comply with any laws, rules or regulations of any governmental
authority or a requirement of Landlord's insurance carrier, or (iii) primarily
for the purpose of improving security at the Property or the Building. The cost
of such capital improvements shall be amortized over the useful life thereof, as
reasonably determined by Landlord, and shall, at Landlord's option, include
interest at a rate that is reasonably equivalent to the interest rate that
Landlord would be required to pay to finance the cost of the capital improvement
in question as of the date such capital improvement is performed.

     D. Basic Costs shall not include the following: (i) costs of alterations of
tenant spaces (including all tenant improvements to such spaces); (ii) costs of
capital improvements, except as provided in Paragraph C above; (iii)
depreciation, interest and principal payments on mortgages, and other debt
costs, if any; (iv) real estate brokers' leasing commissions or compensation and
advertising and other marketing expenses; (v) costs or other services or work
performed for the singular benefit of another tenant or occupant (other than for
Common Areas); (vi) legal, space planning, construction, and other expenses
incurred in procuring tenants for the Building or renewing or amending leases
with existing tenants or occupants of the Building; (vii) costs of advertising
and public relations and promotional costs and attorneys' fees associated with
the leasing of the Building; (viii) any expense for which Landlord actually
receives reimbursement from insurance, condemnation awards, other tenants,
(other than through the payment of additional rent under such tenants' leases)
or any other source; (ix) costs incurred in connection with the sale, financing,
refinancing, mortgaging, or other change of ownership of the Building; (x)
rental under any ground or underlying lease or leases; (xi) any accounting,
legal or other professional expenses; (xii) any expenses for Landlord's own
staff beyond the grade of Building manager, and the staff that is included shall
be only to the extent such persons are involved in the management or operations
of the Building; (xiii) copying, office supplies and other office expenditures
to the extent not involved in the management or operations of the Building; and
(xiv) Taxes.

     E. "Taxes" shall mean (i) all real estate taxes and assessments on the
Property, the Building or the Premises, and taxes and assessments levied in
substitution or supplementation in whole or in part of such taxes, (ii) all
personal property taxes for the Building's common area personal property, (iii)
all sales, use or other tax, excluding state and/or federal income tax now or
hereafter imposed by any governmental authority upon rent received by Landlord,
(iv) all other taxes, fees or assessments now or hereafter levied by any
governmental authority on the Property, the Building or its contents or on the
operation and use thereof (except as relate to specific tenants), and (v) all
reasonable costs and fees incurred in connection with seeking reductions in or
refunds in Taxes including, without limitation, any costs incurred by Landlord
to challenge the tax valuation of the Building or Property, but excluding income
taxes. Estimates of real estate taxes and assessments for any calendar year
during the Lease Term shall be

                                      C-2

<PAGE>

determined based on Landlord's good faith estimate of the real estate taxes and
assessments. Taxes and assessments hereunder are those paid or payable for such
calendar year, as opposed to the real estate taxes and assessments accrued with
respect to such calendar year.

     F. If the Building and the other buildings Landlord operates in conjunction
therewith, if any, are is not at least ninety-five percent (95%) occupied, in
the aggregate, during any calendar year of the Lease Term or if Landlord is not
supplying services to at least ninety-five percent (95%) of the Rentable Area of
the Building and such other buildings, if any, at any time during any calendar
year of the Lease Term, actual Basic Costs for purposes hereof shall, at
Landlord's option, be determined as if the Building and such other buildings had
been ninety-five percent (95%) occupied and Landlord had been supplying services
to ninety-five percent (95%) of the Rentable Area of the Building and such other
buildings during such year. If Basic Costs for any calendar year during the
Lease Term are determined as provided in the foregoing sentence, Basic Costs for
the Base Year shall also be determined as if the Building and such other
buildings, if any, had been ninety-five percent (95%) occupied and Landlord had
been supplying services to ninety-five percent (95%) of the Rentable Area of the
Building and such other buildings.

     G. Tenant shall have the right to inspect, at reasonable times and in a
reasonable manner, during the thirty (30) day period following the delivery of
Landlord's statement of the actual amount of Basic Costs, such of Landlord's
books of account and records as pertain to and contain information concerning
such costs and expenses in order to verify the amounts thereof. Tenant agrees
that any information obtained during an inspection by Tenant of Landlord's books
of account and records shall be kept in confidence by Tenant and its agents and
employees and shall not be disclosed to any other parties, except to Tenant's
attorneys, accountants and other consultants. Any parties retained by Tenant to
inspect Landlord's books of account and records shall not be compensated on a
contingency fee basis. If Tenant shall not dispute any item or items included in
the determination of Basic Costs for a particular Lease Year by delivering a
written notice to Landlord generally describing in reasonable detail the basis
of such dispute within sixty (60) days after the statement for such year was
delivered to it, Tenant shall be deemed to have approved such statement. During
the pendency of any dispute over Basic Costs, Tenant shall pay, under protest
and without prejudice, Tenant's Pro Rata Share of Basic Costs as calculated by
Landlord. The cost of such review shall be paid by Tenant except in the event
the review reveals an error by Landlord which resulted in an overcharge of
actual (as distinguished from estimated) Basic Costs in excess of ten percent
(10%) of the total Basic Costs, in which event Landlord shall pay the reasonable
cost of the review (up to the amount of the overcharge).

                               [END OF EXHIBIT C]

                                      C-3

<PAGE>

                                    EXHIBIT D

                                   WORK LETTER

                  (Landlord completes work within an Allowance)

1.   This Work Letter shall set forth the obligations of Landlord and Tenant
     with respect to the preparation of the Premises for Tenant's occupancy. All
     improvements described in this Work Letter to be constructed in and upon
     the Premises by Landlord are hereinafter referred to as "LANDLORD'S WORK"
     Landlord and Tenant acknowledge that Plans (hereinafter defined) for
     Landlord's Work have not yet been prepared and, therefore, it is impossible
     to determine the exact cost of Landlord's Work at this time. Accordingly,
     Landlord and Tenant agree that Landlord's obligation to pay for the. cost
     of Landlord's Work shall be limited to $190,976.00 (the "CONSTRUCTION
     ALLOWANCE") AND that Tenant shall be responsible for the cost of Landlord's
     Work to the extent that it exceeds. the Construction Allowance. If the
     actual cost of Landlord's Work is less than the Construction Allowance,
     Tenant shall not be entitled to any credit, payment or abatement on account
     thereof. Landlord shall enter into a direct contract for Landlord's Work
     with a general contractor selected by Landlord. In addition, Landlord shall
     have the right to select and/or approve of any subcontractors used in
     connection with Landlord's Work. Tenant shall pay Landlord, within ten (10)
     days after Landlord's written demand, a construction fee equal to five
     percent (5%) of the cost of Landlord's Work to compensate for its
     construction management services in connection with Landlord's Work.
     Landlord reserves the right to deduct such fee from the Construction
     Allowance.

2.   Space planning, architectural and any necessary and required engineering
     (mechanical, electrical and plumbing) drawings for Landlord's Work shall be
     prepared at Tenant's sole cost and expense, subject to funding through the
     Construction Allowance. The space planning, architectural and mechanical
     drawings are collectively referred to herein as the "PLANS". The Plans
     shall be deemed to be the Construction Drawings for the Premises dated
     October 1, 2004, prepared by Davis & Davis.

3.   Neither the approval of the Plans nor the supervision of Landlord's Work by
     Landlord shall constitute a representation or warranty by Landlord as to
     the accuracy, adequacy, sufficiency and propriety of the Plans or the
     quality of workmanship or compliance of Landlord's Work with applicable
     law.

4.   Prior to commencing any construction of Landlord's Work, Landlord shall
     submit to Tenant a written estimate setting forth the anticipated cost of
     Landlord's Work, including but not limited to labor and materials,
     architect's fees, contractor's fees and permit fees. Within three (3)
     Business Days thereafter, Tenant shall either notify Landlord in writing of
     its approval of the cost estimate, or specify its objections thereto in
     reasonable detail and any desired changes to the proposed Landlord's Work.
     In the event Tenant notifies Landlord of such objections and desired
     changes, Tenant shall work with Landlord in good faith to alter the scope
     of Landlord's Work in order to reach a mutually acceptable alternative cost
     estimate.

5.   If Landlord's estimate and/or the actual cost of Landlord's Work shall
     exceed the

                                      D-1

<PAGE>

     maximum Construction Allowance (such excess being herein referred to as the
     "Excess Costs"), Tenant shall pay to Landlord such Excess Costs within two
     (2) Business Days after Landlord's written demand. Landlord shall not be
     required to proceed with Landlord's Work until Tenant pays such Excess
     Costs and any delay in the completion of Landlord's Work due to a delay by
     Tenant in making such payment shall be deemed a Delay pursuant to the
     Lease. The statements of costs submitted to Landlord by Landlord's
     contractors shall be conclusive for purposes of determining the actual cost
     of the items described therein. Excess Costs constitute Rent payable
     pursuant to the Lease, and the failure to timely pay same constitutes an
     Event of Default under the Lease.

6.   If Tenant shall request any changes to Landlord's Work that are approved by
     Landlord ("CHANGE ORDERS"), Landlord shall have any necessary revisions to
     the Plans prepared, and if as a result of such Change Orders the cost of
     the Landlord's Work shall exceed the Construction Allowance, then Tenant
     shall reimburse Landlord on demand' for such excess Cost. Landlord shall
     notify Tenant in writing of the estimated increased cost, if any, by reason
     of such Change Orders, and Tenant shall, within one (1) Business Day after
     receiving Landlord's estimate of the cost of the Change Order, notify
     Landlord in writing whether it desires to proceed with such Change Order.
     In the absence of such written authorization, Landlord shall have the
     option to continue work on the Premises disregarding the requested Change
     Order, or Landlord may elect to discontinue work on the Premises until it
     receives notice of Tenant's decision, in which event Tenant shall be
     responsible for any Delay in completion of Landlord's Work resulting
     therefrom.

7.   Following approval of the Plans and the payment by Tenant of the required
     portion of the Excess Costs, if any, Landlord shall cause Landlord's Work
     to be constructed substantially in accordance with the approved Plans, so
     long as no default shall occur under the Lease. Landlord shall notify
     Tenant upon substantial completion of Landlord's Work. The phrase
     "SUBSTANTIAL COMPLETION" shall mean that Landlord's Work has been completed
     except for such incomplete items as would not materially interfere with the
     use of the Premises for the Permitted Use.

8.   If Landlord shall be delayed in substantially completing Landlord's Work as
     a result of the occurrence of any of the following (a "Delay"):

     (a)  Tenant's failure to timely furnish information to complete the Plans,
          or otherwise in accordance with this Work Letter, or to respond to any
          request by Landlord for any approval or information within any time
          period prescribed, or if no time period is prescribed, then within two
          (2) Business Days of such request; or

     (b)  Tenant's request for materials, finishes or installations that have
          long lead times after having first been informed by Landlord that such
          materials, finishes or installations will cause a Delay; or

     (c)  Changes in any plans and specifications requested by Tenant; or

     (d)  The performance or nonperformance by a person or entity employed by or
          on behalf of Tenant in the completion of any work in the Premises (all
          such work and such persons or entities being subject to prior approval
          of Landlord); or

                                      D-2

<PAGE>

     (e)  Any request by Tenant that Landlord delay the completion of any
          component of Landlord's Work; or

     (f)  Any breach or default by Tenant in the performance of Tenant's
          obligations under the Lease; or

     (g)  Tenant's failure to pay any amounts as and when due under this Work
          Letter; or

     (h)  Any delay resulting from Tenant's having taken possession of the
          Premises for any reason prior to substantial completion of Landlord's
          Work; or

     (i)  Any other delay chargeable to Tenant, its agents, employees or
          independent contractors;

          then, for purposes of determining the Commencement Date, the date of
     substantial completion shall be deemed to be the day that Landlord's Work
     would have been substantially completed absent any such Delay. Landlord's
     Work shall be deemed to be substantially completed on the date that
     Landlord's Work has been performed (or would have been performed absent any
     Delay), other than any details of construction, mechanical adjustment or
     any other matter, the noncompletion of which does not materially interfere
     with Tenant's use of the Premises. The adjustment of the Commencement Date
     and, accordingly, the postponement of Tenant's obligation to pay Base Rent
     and other sums due under the Lease shall be Tenant's sole remedy that
     Tenant might otherwise have against Landlord by reason of the Premises not
     being ready for occupancy by Tenant on the Target Commencement Date.
     Promptly after. the determination of the Commencement Date, Landlord and
     Tenant shall enter into a letter agreement (the "COMMENCEMENT LETTER") on
     the form attached to the Lease as EXHIBIT F setting forth the Commencement
     Date, the Expiration Date and any other dates that are affected by the
     adjustment of the Commencement Date. The Commencement Letter shall identify
     any minor incomplete items of Landlord's Work as reasonably determined by
     Landlord's architect (the "PUNCHLIST ITEMS"), which Punchlist Items
     Landlord shall promptly remedy. Tenant, within five (5) days after receipt
     thereof from Landlord, shall execute the Commencement Letter and return the
     same to Landlord. Notwithstanding anything herein to the contrary, Landlord
     may elect, by written notice to Tenant, not to adjust the Commencement Date
     as provided above if such adjustment would cause Landlord to be in
     violation of the existing rights granted to any other tenant of the
     Building. If Landlord elects not to adjust the Commencement Date, the
     Commencement Date shall be the Target Commencement Date, provided that Base
     Rent and Additional Rent shall not commence until the date that Landlord's
     Work has been substantially completed (or would have been substantially
     completed absent any Delays).

9.   This Work Letter shall not be deemed applicable to any additional space
     added to the original Premises at any time or from time to time, whether by
     any options under the Lease or otherwise, or to any portion of the original
     Premises or any additions to the Premises in the event of a renewal or
     extension of the original Lease Term, whether by any options under the
     Lease or otherwise, unless expressly so provided in the Lease or any
     amendment or supplement to the Lease. All capitalized terms used in this
     Work Letter but not defined herein shall have the same meanings ascribed to
     such terms in the Lease.

                                      D-3

<PAGE>

10.  Tenant shall perform all work (other than Landlord's Work) in accordance
     with the terms of this Work Letter as required to put the Premises in a
     condition to permit the conduct of Tenant's business therein and in
     accordance with the requirements of this Lease. When Landlord's Work has
     proceeded to the point where the work to be performed by Tenant and the
     installation of Tenant's trade fixtures, furniture and equipment in the
     Premises (collectively "Tenant's Work") can, in the opinion of Landlord, be
     commenced in accordance with good construction practice, then Tenant shall
     have the right to occupy the Premises for the purpose of performing
     Tenant's Work so far as its occupancy is not inconsistent with Landlord's
     Work or any work to be done in the Building by Landlord, subject to all the
     terms and condition of this Lease (including in particular Section 9B),
     except that the payment of Rent by Tenant shall not commence until the
     Commencement Date. Tenant acknowledges that entry onto the Premises when
     the Landlord's Work is not substantially complete entails a risk of
     personal injury, death, or damage, destruction, loss or misappropriation of
     property. To the extent not expressly prohibited by law, Tenant hereby
     assumes all such risks for entry onto the Premises, and agrees to defend
     and hold harmless Landlord (its agents, contractors, and employees) against
     all costs and expenses, including reasonable attorneys' fees in connection
     therewith, arising out of any personal injury, death, or damage,
     destruction, loss or misappropriation of property related to entry onto the
     Premises by Tenant or its agents, employees, contractors, invitees or
     subtenants prior to such time as the Landlord's Work is substantially
     complete, except to the extent such costs or expenses arise out of the
     negligence or willful misconduct of Landlord, its employees, agents or
     representatives (it being expressly understood that for purposes of this
     Lease, Landlord's contractors, subcontractors and their employees shall not
     be considered employees, agents or representatives of Landlord). Tenant
     shall be solely responsible to determine at the site all dimensions of the
     Premises and the Building which affect any work to be performed by Tenant
     hereunder. The installation of Tenant's furniture, fixtures, equipment and
     personalty into the Premises shall be the sole responsibility of Tenant,
     and any costs associated therewith shall be borne by Tenant. Neither review
     nor approval by Landlord of any plans or specifications for Tenant's Work
     or any other work to be performed by Tenant shall constitute a
     representation or warranty by Landlord that any of such plans or
     specifications either (i) are complete or suitable for their intended
     purpose, or (ii) comply with applicable laws, ordinances, codes and
     regulations.

                               [END OF EXHIBIT D]

                                      D-4

<PAGE>

                                    EXHIBIT E

                             ADDITIONAL PROVISIONS

1. SECURITY DEPOSIT.

     A. Notwithstanding anything to the contrary contained in Sections IF and 5
of the Lease, in lieu of a cash security deposit, Tenant herewith deposits with
Landlord as security for the prompt, full, and faithful performance by Tenant.
of every term, covenant and condition of this Lease, an irrevocable letter of
credit ("Letter of Credit") payable in Chicago, Illinois, miming in favor of
Landlord issued by a bank reasonably acceptable to Landlord in the amount of the
Security Deposit described in Section IF above. The Letter of Credit shall be
irrevocable for the term of this Lease and shall provide that it is
automatically renewable for a period ending not earlier than sixty (60) days
after the expiration of the Lease Term without any action whatsoever on the part
of Landlord.

     B. Without limiting the generality of the foregoing, if the Letter of
Credit expires earlier than sixty (60) days after the expiration of the Lease
Term, or the issuing bank notifies Landlord in writing (by certified/registered
mail, return receipt requested or overnight courier) that it shall not renew the
Letter of Credit, Landlord will accept a renewal thereof or substitute letter of
credit (such renewal or substitute letter of credit to be in effect not later
than thirty (30) days prior to the expiration thereof), irrevocable and
automatically renewable as above provided to sixty (60) days after the end of
the Lease Term upon the same terms as the expiring Letter of Credit or such
other terms as may be acceptable to Landlord. However, (i) if the Letter of
Credit is not timely renewed or a substitute letter of credit is not timely
received, (ii) or if Tenant fails to maintain the Letter of Credit in the amount
and terms set forth in this Section, Tenant, at least thirty (30) days prior to
the expiration of the Letter of Credit, or immediately upon its failure to
comply with each and every term of this Section, must deposit with Landlord cash
security in the amounts required by, and to be held subject to and in accordance
with, all of the terms and conditions set forth herein, failing which the
Landlord may present such Letter of Credit to the bank in accordance with the
terms of this Section, and the entire sum secured thereby shall be paid to
Landlord, to be held by Landlord as provided in this Section.

     C. Provided that Tenant has not defaulted in the performance of any of its
obligations under the Lease beyond any applicable notice or cure period, (i) at
any time after the end of the fifteenth (15th) full calendar month of the Lease
Term, Tenant may reduce the face amount of the Letter of Credit to $75,000.00,
and (ii) Tenant shall not be required to maintain a Letter of Credit if at the
end of the thirty-ninth (39th) full calendar month of the Lease Term, or at any
time thereafter, the cash balance (as reported on Tenant's balance sheet and
other financial statements, as certified by Tenant's authorized financial
officer or accounting firm) equals or exceeds the difference between (a)
Tenant's expenses in the immediately preceding eight calendar months, and (b)
Tenant's revenues in the immediately preceding eight calendar months.

     D. Tenant agrees that, in the event of any default by Tenant under this
Lease, after

                                       E-1

<PAGE>

the expiration of any applicable notice or cure period, Landlord shall have the
right to draw down, apply or retain the whole or any part of the Letter of
Credit in an amount necessary to cure such default (the "Cure Amount"),
including, without limitation for the payment of (i) any Base Rent, Additional
Rent or other sums of money which Tenant may not have paid when due, (ii) any
sum expended by Landlord in Tenant's behalf in accordance with the provisions of
this Lease, and (iii) any sum which Landlord may expend or be required to expend
by reason of Tenant's default, or any loss or damage which Landlord may suffer
or incur, including, without limitation, any damage or deficiency in or from the
reletting of the Premises as provided in the Lease. If, as a result of any such
application of all or any part of such security, the amount secured by the
Letter of Credit shall be less than the amount set forth in Section IF above,
Tenant agrees that within five (5) days of receipt of notice of any such draw,
use or application of the Cure Amount, Tenant shall provide Landlord with
additional letter(s) of credit or cash collateral in an amount equal to the
deficiency.

     E. Tenant further agrees that, in addition to all of the rights and
remedies provided to Landlord pursuant to this Lease, whether or not this Lease
or Tenant's right to possession hereunder has been terminated, in the event
Tenant has filed (or there has been filed against Tenant) a petition for
bankruptcy protection or other protection from its creditors under any
applicable and available law, then Landlord may at once and without notice to
Tenant be entitled to draw down upon the entire amount of the Letter of Credit
(or apply any cash collateral) then available to Landlord and apply such
resulting sums toward (i) reimbursement to Landlord for all of Landlord's then
unamortized costs (including, cost to Landlord of improving the Premises)
incurred in leasing to Tenant the Premises demised by this Lease, and (ii)
reimbursement to Landlord for any other damages suffered by Landlord as a result
of such default.

     F. The use, application or retention of the Letter of Credit, or any
portion thereof, by Landlord shall not prevent Landlord from exercising any
other right or remedy provided by the Lease or by law (it being intended that
Landlord shall not first be required to proceed against the collateral) and
shall not operate as a limitation on any recovery to which Landlord may
otherwise be entitled.

     G. In the event of a transfer of Landlord's interest in the Building,
Landlord shall have the right to transfer the Letter of Credit to the transferee
and thereupon the Landlord shall, without any further agreement between the
parties, be released by Tenant from all liability therefor, and it is agreed
that the provisions hereof shall apply to every transfer or assignment of the
Letter of Credit to a new Landlord. Tenant shall pay upon Landlord's demand, as
additional rent, any and all costs or fees charged in connection with the Letter
of Credit that arise due to: (i) Landlord's sale or transfer of all or a portion
of the Building; or (ii) the addition, deletion, or modification of any
beneficiaries under the Letter of Credit.

     H. Tenant further covenants that it will not assign or encumber the Letter
of Credit or any part thereof and that neither Landlord nor its successors or
assigns will be bound by any such assignment, encumbrance, attempted assignment
or attempted encumbrance.

     I. Upon the date which is not more than sixty (60) days after the
expiration or earlier termination of this Lease, Landlord shall return any
remaining Letters of Credit to Tenant and

                                      E-2

<PAGE>

execute any reasonable documentation requested by Tenant to effect the
termination of the same.

2. CONTINGENCY.

     Notwithstanding anything to the contrary contained in this Lease, the
validity and effectiveness of this Lease is contingent upon Landlord entering
into an agreement with the University of Michigan Credit Union ("UMCU") for
access to the portions of the Premises leased by UMCU, the right to perform
improvements therein, and early termination, as applicable, all on terms
reasonably satisfactory to Landlord. If Landlord does not enter into such
agreement, this Lease shall be terminable at the option of either Tenant or
Landlord, in which event this Lease shall be void and of no force or effect.

3. TERMINATION OPTION.

     A. Tenant shall have one option to terminate the Lease (the "Termination
Option") effective as of the last day of the sixty-third (63rd) full calendar
month following the Commencement Date (the "Termination Date"). The Termination
Option is granted subject to the following terms and conditions: (1) Landlord
receives not less than six (6) months prior to the Termination Date, time being
of the essence, a written notice (the "Termination Notice") of Tenant's election
to exercise the Termination Option; (2) simultaneously with delivery of the
Termination Notice Tenant shall pay Landlord $51,762.12 (the "Termination Fee");
and (3) Tenant is not in default under the Lease beyond any applicable notice or
cure period on the date that Tenant exercises the Termination Option, anytime
after the date Tenant exercises the Termination Option, or on the Termination
Date, unless waived in writing by Landlord (and if the Termination Option is so
nullified after payment of the Termination Fee, then the Termination Fee shall
be returned to Tenant).

     B. If Tenant timely and properly exercises the Termination Option, (1) all
Rent owing under the Lease shall be paid through and apportioned as of the
Termination Date; (2) neither party shall have any rights, estates, liabilities
or obligations under the Lease for the period first accruing after the
Termination Date, except those which, by the provisions of the Lease, expressly
survive the expiration or termination of the term of the Lease; and (3) Tenant
shall surrender and vacate the Premises and deliver possession thereof to
Landlord not later than the Termination Date in the condition required under the
Lease for surrender of the Premises.

     C. The Termination Option shall automatically terminate and become null and
void upon the earlier to occur of: (1) the termination of Tenant's right to
possession of the Premises; (2) the assignment of the Lease by Tenant, in whole
or in part (other than as permitted under the Lease without the need for
Landlord's consent); (3) the sublease by Tenant of the Premises, or any part
thereof (other than as permitted under the Lease without the need for Landlord's
consent); or (4) the failure of Tenant to timely or properly exercise the
Termination Option.

4. RIGHT OF FIRST OFFER.

     A. As used herein, the term "Offer Space" shall mean the 709 rentable
square feet of office space contiguous to the Premises (Suite 102) on the first
floor of the Building, and which

                                      E-3

<PAGE>

becomes available for lease during the Lease Term. Tenant shall have, subject to
the currently existing rights of tenants and option holders, and their
successors and assigns, and the right of Landlord to renew or extend the lease
with any tenant (and their successors and assigns) currently in the Offer Space,
the option to lease the Offer Space on the same terms and conditions as Landlord
then proposes to offer the Offer Space to third parties, except as otherwise
provided herein. At the time Landlord first proposes to offer the Offer Space or
any portion thereof for lease to the market or to third parties, Landlord shall
deliver to Tenant written notice of its intention along with a copy of the
proposed terms. Tenant shall exercise its option by written notice to Landlord
delivered within five (5) business days of Landlord's notice to Tenant. If
Tenant exercises its right of first offer, it shall lease the Offer Space on the
terms and conditions set forth in the lease proposal attached to Landlord's
notice. If Tenant fails to exercise its right of first offer as specified
herein, then Landlord may thereafter offer to lease the Offer Space to third
parties on such terms and conditions as Landlord finds acceptable without first
offering such space to Tenant. In the event that Tenant exercises the right of
first offer set forth herein, Tenant agrees to enter into an amendment to this
Lease incorporating the Offer Space, the change in Base Rent applicable thereto,
and any other applicable changes within thirty (30) days following the exercise
of this right of first offer, but in no event shall a delay in the full
execution of such amendment nullify Tenant's exercise of the right of first
offer.

     B. Tenant's exercise of the foregoing right of first offer is subject to
the conditions that (i) the Lease is in full force and effect, (ii) Tenant is
not in default hereunder at the time of notification or at any time after
notification, (iii) neither the Premises nor any part thereof have been sublet
(other than as permitted under the Lease without the need for Landlord's
consent), (iv) Tenant has not assigned the Lease (other than as permitted under
the Lease without the need for Landlord's consent), and (v) Tenant occupies the
Premises itself.

5. TEMPORARY SPACE.,

     Notwithstanding anything to the contrary contained in this Lease, prior to
the Commencement Date, Landlord will make available to Tenant office space in
the Building on a temporary basis (hereinafter referred to as the "Temporary
Space"), such suite to be mutually acceptable to the parties. All of the terms
and conditions of this Lease shall apply to the lease of the Temporary Space (as
if Landlord and Tenant had entered into a separate lease of the Temporary
Space), except that (a) Tenant shall pay no Base Rent or Additional Rent for the
Temporary Space (except that Tenant shall be responsible for all utility charges
to the Temporary Space), (b) Tenant's right to use the Temporary Space shall
expire on the Commencement Date of this Lease, and (c) Tenant shall accept the
Temporary Space in its current "AS IS" condition.

                               [END OF EXHIBIT E]

                                      E-4

<PAGE>

                                    EXHIBIT F

                               COMMENCEMENT LETTER

Date _______________________________

Tenant _____________________________

Address ____________________________

____________________________________

Re: Commencement Letter with respect to that certain Lease dated ________ by and
    between ________________, as Landlord, and ______________, a(n)
    ______________, as Tenant, for a Rentable Area in the Premises of
    _________square feet on the ______ floor of the Building located at
    ____________________, _____________, _________.

    Dear __________________:

     In accordance with the terms and conditions of the above referenced Lease,
Tenant hereby accepts possession of the Premises and agrees as follows:

     The Commencement Date of the Lease is _____________________________________

     The Expiration Date of the Lease is _______________________________________

     Landlord agrees to complete the work in the Premises identified in the
punchlist jointly prepared by Landlord and Tenant dated . Tenant accepts
possession of the Premises subject to Landlord's obligation to complete the work
identified on the punchlist.

     Please acknowledge your acceptance of possession and agreement to the terms
set forth above by signing all three (3) copies of this Commencement Letter in
the space provided and returning two (2) fully executed copies of the same to my
attention.

Sincerely,

XXXXXXXXX
Property Manager

Agreed and Accepted:

TENANT:

By:
    --------------------------------
Name:
      ------------------------------
Title:
       -----------------------------

                                       F-1

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