Document:

Exhibit 101

		
			
		

		
			Pain Therapeutics, Inc.
		

		
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			March 20, 2019
		

		
			Via Email and Registered Mail 
		

		
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			James E. Brown, DVM 
		

		
			President & CEO 
		

		
			Durect Corporation 
		

		
			10260 Bubb Road 
		

		
			Cupertino, CA  95014-4166
		

		
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			Dear Jim,
		

		
			As you know, Pain Therapeutics, Inc. (“PTI”) is exclusive licensee of certain rights granted by Durect Corporation and its wholly-owned subsidiary, Southern BioSystems Inc., (together, “Durect”), as set forth in a DEVELOPMENT AND LICENSE AGREEMENT dated December 19, 2002 (the “DLA”) and amended from time-to-time.  
		

		
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			This letter is to inform that PTI hereby provides written notice of termination of the DLA in its entirely, without cause. Pursuant to Section 15.2 of the DLA, such termination of the DLA shall be effective automatically without further action by either party ninety (90) days from today, or June 18, 2019.  Of course, you may terminate the DLA sooner than June 18, 2019 by providing us with the appropriate written notice.  For clarity, we are not aware of any disputes, claims or controversies regarding the DLA.  
		

		
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			Within thirty (30) days, we will endeavor to send you a copy of Confidential Information, as that term is defined in Section 13.1 of the DLA.  We intend to keep one copy of any such Confidential Information for record-keeping purposes.
		

		
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		On a personal note, I look back with pride at our collective ability to conceive, build and test a highly abuse-deterrent oxycodone drug product from scratch, and for doing so at a time when pundits told us it couldn’t be done.  As a direct result of our collective efforts, we successfully moved the entire opioid industry towards safer drug formulations. This alone has saved more lives than we’ll ever know.    For this reason, I feel the journey was worth the effort, even if the destination isn’t quite what we expected.  In closing, I salute all your scientists, thinkers and professionals who participated in our remarkable journey together.  I wish you the best as you move Durect in novel scientific directions.    
		

		
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			Sincerely,
		

		
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			/s/ Remi Barbier
		

		
			Remi Barbier
		

		
			Chairman, President & CEO
		

		
			Pain Therapeutics, Inc.
		

		
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			Cc: Michael H. Arenberg, J.D, Chief Financial Officer, Durect Corporation
		

		
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			Page 2 of 2myfw_Ex10_1

		
			Exhibit 10.1
		

		
			 
		

		
			NINTH AMENDMENT TO BUSINESS LOAN AGREEMENT
		

		
			 
		

		
			THIS NINTH AMENDMENT TO BUSINESS LOAN AGREEMENT is made as of March 18, 2019, by and between FIRST WESTERN FINANCIAL, INC., a Colorado corporation (the “Borrower”), and BMO HARRIS BANK N.A., as successor-by-merger to M&I Marshall and Ilsley Bank, a national banking association  (“Lender”).
		

		
			 
		

		
			In consideration of the mutual covenants, conditions and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, it is hereby agreed that:
		

		
			 
		

		
			ARTICLE I
		

		
			DEFINITIONS
		

		
			 
		

		
			When used herein, the following terms shall have the following meanings specified:
		

		
			 
		

		
			1.1       “Amendment” shall mean this Ninth Amendment to Business Loan Agreement.
		

		
			 
		

		
			1.2       “Credit Agreement” shall mean the Business Loan Agreement dated as of October 31, 2009, as amended, by and between the Borrower and Lender.
		

		
			 
		

		
			1.3       Other Capitalized Terms. All capitalized terms used in this Amendment and not specifically defined herein shall have the definitions assigned to such terms in the Credit Agreement.
		

		
			 
		

		
			ARTICLE II
		

		
			AMENDMENTS
		

		
			 
		

		
			2.1       Amendments.  The Affirmative Covenants, Subsection Financial Covenants and Ratios, Subsection Non-performing Loans to Total Loans is hereby amended and restated in its entirety to read as follows:
		

		
			 
		

		
			“Non-performing Loans to Total Loans.  Bank shall maintain at all times a ratio of Non-performing Loans to Total Loans, which is less than or equal to (a) 3.0%, for the fiscal quarters ending March 31, 2019 through September 30, 2019 and (b) 2.0% for the fiscal quarter ending December 31, 2019 and each fiscal quarter thereafter.  “Non-performing Loans” means loans outstanding which are not accruing interest, have been classified as renegotiated pursuant to guidelines established by the Federal Financial Examination Institution Council or are 90 days or more past due in the payment of principal or interest.  “Total Loans” means the sum of loans and direct lease financings, net of unearned income of Bank.”
		

		
			 
		

		
			2.2       Miscellaneous Amendments.  The Credit Agreement, the related loan documents and all other agreements and instruments executed and delivered heretofore or hereafter pursuant to the Credit Agreement are amended hereby so that any reference therein to the Credit Agreement
		

		
			 
		

		
			
		

		
			

		 

 

		

		
			 
		

		
			shall be deemed to be a reference to such agreements and instruments as amended by or pursuant to this Amendment.
		

		
			 
		

		
			ARTICLE III
		

		
			REPRESENTATIONS AND WARRANTIES OF THE BORROWER
		

		
			 
		

		
			The Borrower hereby represents and warrants to the Lender that:
		

		
			 
		

		
			3.1       Credit Agreement.  All of the representations and warranties made by the Borrower in the Credit Agreement are true and correct on the date of this Amendment.  Except for the Event of Default waived pursuant to Section 4.10 hereof, no Default or Event of Default under the Credit Agreement has occurred and is continuing as of the date of this Amendment.
		

		
			 
		

		
			3.2       Authorization; Enforceability.  The making, execution and delivery of this Amendment and performance of and compliance with the terms of the Credit Agreement has been duly authorized by all necessary organizational action by the Borrower.  This Amendment is the valid and binding obligation of the Borrower, enforceable against the Borrower in accordance with its terms.
		

		
			 
		

		
			3.3       Absence of Conflicting Obligations.  The making, execution and delivery of this Amendment and performance of and compliance with the terms of the Credit Agreement, as amended, do not violate any presently existing provision of law or the articles of organization or operating agreement of the Borrower or any agreement to which the Borrower is a party or by which it or any of its assets is bound.
		

		
			 
		

		
			ARTICLE IV
		

		
			MISCELLANEOUS
		

		
			 
		

		
			4.1       Continuance of Credit Agreement.  Except as specifically amended by this Amendment, the Credit Agreement shall remain in full force and effect.
		

		
			 
		

		
			4.2       Survival.  All agreements, representations and warranties made in this Amendment or in any documents delivered pursuant to this Amendment shall survive the execution of this Amendment and the delivery of any such document.
		

		
			 
		

		
			4.3       Governing Law.  This Amendment shall be governed by, and construed and interpreted in accordance with, the laws of the State of Wisconsin applicable to agreements made and wholly performed within such state.
		

		
			 
		

		
			4.4       Counterparts; Headings.  This Amendment may be executed in several counterparts, each of which shall be deemed an original, but such counterparts shall together constitute but one and the same agreement.  Article and section headings in this Amendment are inserted for convenience of reference only and shall not constitute a part hereof.
		

		
			 
		

		
			
		

		
			

		 

		

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			4.5       Severability. Any provision of this Amendment which is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions of this Amendment in such jurisdiction or affecting the validity or enforceability of any provision in any other jurisdiction.
		

		
			 
		

		
			4.6       Conditions.  The effectiveness of this Amendment is subject to the Lender having received on or before the date hereof, an executed copy of this Amendment and such additional supporting documents and materials as the Lender may reasonably request.
		

		
			 
		

		
			4.7       Course of Dealing. The Borrower acknowledges that neither previous waivers, extensions and amendments granted to the Borrower by the Lender nor the amendments granted herein create any course of dealing or expectation with respect to any further waivers, extensions or amendments and further acknowledges that the Lender have no obligation whatsoever to grant any additional waivers, extensions, amendments or forbearance.
		

		
			 
		

		
			4.8       No Defenses. The Borrower acknowledges it has no defenses, rights of setoff or rights of recoupment to the enforceability or payment of any of its obligations under the Credit Agreement as amended hereby.
		

		
			 
		

		
			4.9       Expenses and Attorneys’ Fees.  The Borrower shall pay reasonable fees and expenses (including attorneys’ fees) incurred by Lender in connection with the preparation, execution and delivery of this Amendment.
		

		
			 
		

		
			4.10     Waiver. The Borrower has informed the Lender that the Borrower was in violation of the Non-performing Loans to Total Loans financial covenant contained in the financial covenants section of the Credit Agreement for the period ending December 31, 2018, which violations constitute an Event of Default under the Credit Agreement (the “Existing Default”).  The Company has requested that the Lender waive the Existing Default.  To that end, the Lender hereby waives the Existing Default.  This limited waiver of the Existing Default shall be effective only for the specific purposes set forth herein and shall not be deemed to be a further or continuing waiver or amendment of any other section or provision of the Credit Agreement or a waiver of any other past or future Event of Default under the Credit Agreement.
		

		
			 
		

		
			[signature page to follow]
		

		
			 
		

		
			
		

		
			

		 

		

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			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the day and year first written above.
		

		
			 
		

			
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						BORROWER:

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						FIRST WESTERN FINANCIAL, INC.

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						By: 

					
					
						/s/ Scott C. Wylie

				
	
					
						 

					
					
						Name: 

					
					
						Scott C. Wylie

				
	
					
						 

					
					
						Title: 

					
					
						CEO

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						FIRST WESTERN FINANCIAL, INC.

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						By: 

					
					
						/s/ Julie A. Courkamp

				
	
					
						 

					
					
						Name: 

					
					
						Julie A. Courkamp

				
	
					
						 

					
					
						Title: 

					
					
						CFO

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						LENDER:

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						BMO HARRIS BANK N.A.

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						By: 

					
					
						/s/ Lori Keller

				
	
					
						 

					
					
						Name: 

					
					
						Lori Keller

				
	
					
						 

					
					
						Title: 

					
					
						VP

				

		
			 
		

		 

		

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